pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Physiotherapy Program Effect on Musculoskeletal Dysfunctions in Young Football Players
Status: RECRUITING
Conditions: Flatfoot, Flexible|Pes Valgus|Pes Varus|Balance; Distorted|Diastasis|Weak; Muscle
Interventions: BEHAVIORAL: Neurophysiology-based exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing Effect of Topical Tacrolimus 0.03% Versus Cyclosporine 0.05% in Dry Eyes of Secondary Sjogren Syndrome
Status: COMPLETED
Conditions: Dry Eye|Sjogren Syndrome
Interventions: DRUG: Cyclosporins|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bicalutamide With or Without Everolimus in Treating Patients With Recurrent or Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Bicalutamide|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adding Prednisolone During Ovulation Induction With CC in Lean Women With CC Resistant PCOS
Status: UNKNOWN
Conditions: Infertility|Polycystic Ovarian Syndrome
Interventions: DRUG: Clomiphene citrate and Prednisolone|DRUG: Clomiphene citrate and folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of the Effect of Intra-Dermal Insulin Injection on Blood Glucose Levels After Eating
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Regular insulin (Humulin)|DRUG: Insulin lispro (Humalog)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ipsilateral High Thoracic Ultrasound-guided Erector Spinae Plane Block in Thoracic Cancer Surgeries
Status: COMPLETED
Conditions: Thoracotomy|Erector Spinae Plane Block|Thoracic Cancer|Shoulder Pain
Interventions: PROCEDURE: Thoracic Epidural Analgesia (TEA) group|PROCEDURE: Thoracic Epidural Analgesia and Erector Spinae Plane Block (ESPB) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Gemcitabine Hydrochloride, Cisplatin, and Sunitinib Malate as First-Line Therapy in Treating Patients With Locally Advanced And/or Metastatic Transitional Cell Carcinoma of the Urothelium (SUCCINCT)
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter|Urethral Cancer
Interventions: DRUG: cisplatin|DRUG: gemcitabine hydrochloride|DRUG: sunitinib malate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Checkpoint Inhibition and Chemoradiotherapy as Bladder Sparing Treatment in UC
Status: ACTIVE_NOT_RECRUITING
Conditions: Urothelial Carcinoma|Bladder Cancer
Interventions: DRUG: Ipilimumab + nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Tranexamic Acid After Oral, Intramuscular or Intravenous Administration: a Prospective, Randomised, Cross-over Trial in Healthy Volunteers.
Status: COMPLETED
Conditions: Healthy Volunteer Study
Interventions: DRUG: Tranexamic Acid 1 gram intravenously|DRUG: Tranexamic acid 2 grams oral solution|DRUG: Tranexamic acid 1 gram intramuscular
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impact of the Korea Early Childhood Home-visiting Intervention
Status: ACTIVE_NOT_RECRUITING
Conditions: Child Development|Parenting|Infant Development|Pregnancy Related|Maternal Distress
Interventions: BEHAVIORAL: Targeted nurse-led home visiting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Influence of Daily Activities on Retinal Microcirculation
Status: COMPLETED
Conditions: Retinal Microcirculation Disorder
Interventions: BEHAVIORAL: Beverage consumption|BEHAVIORAL: Daily reading|BEHAVIORAL: Body motion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase Ib Trial of MSP 3 LSP in 1-2 Year Old Children in Burkina Faso
Status: UNKNOWN
Conditions: Malaria
Interventions: BIOLOGICAL: MSP 3 Long Synthetic Peptide|BIOLOGICAL: Hepatitis B vaccine|BIOLOGICAL: Hepatitis B control vaccince
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ombitasvir/ABT-450/Ritonavir and Dasabuvir With or Without Ribavirin in HCV Genotype 1-Infected Adults With Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Hepatitis C|Hepatitis C Virus|Compensated Cirrhosis|Severe Renal Impairment|End-stage Renal Disease
Interventions: DRUG: ombitasvir/paritaprevir/ritonavir|DRUG: dasabuvir|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (MK-7962-003/A011-11)(STELLAR)
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: BIOLOGICAL: Sotatercept|DRUG: Placebo|DRUG: Background PAH Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-response Effects of Soybean Oil in Salad Dressing on Carotenoid/Fat-soluble Vitamin Bioavailability in Salad Vegetables
Status: COMPLETED
Conditions: Biological Availability
Interventions: OTHER: Soybean oil in salad dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: A Randomised, Blinded Study on Laparoscopic Mesh Reinforcement for Chronic Groin Pain
Status: UNKNOWN
Conditions: Chronic Groin Pain
Interventions: PROCEDURE: Pre peritoneal mesh placement|PROCEDURE: Laparoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trans-catheter Chemo-embolization Combined With rAd-p53 Gene Injection in Treatment of Advanced Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Advanced Adult Hepatocellular Carcinoma
Interventions: DRUG: TACE plus rAd-p53 artery injection|DRUG: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)
Status: NOT_YET_RECRUITING
Conditions: Recurrent Lung Non-Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Lymphoscintigraphy|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Ramucirumab|DRUG: Tepotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Delayed Cord Clamping in Very Low Birth Weight Infants
Status: TERMINATED
Conditions: Very Low Birth Weight Infants|Premature Infants|Intraventricular Hemorrhage
Interventions: PROCEDURE: Delayed cord clamping at 30 seconds|PROCEDURE: Delayed cord clamping at 60 seconds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficacy and Safety of Common Sage in Controlling Hot Flashes in Prostate Cancer Patients Treated by Androgen Deprivation
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: OTHER: Administration of Common Sage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Progestagens for the Tertiary Prophylaxis of Preterm Delivery
Status: COMPLETED
Conditions: Preterm Delivery|Neonatal Complications
Interventions: DRUG: 17 alpha-hydroxy progesterone caproate|DRUG: micronized Progesterone|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Muscle Architecture and Muscle Strength in Fibromyalgia
Status: RECRUITING
Conditions: Fibromyalgia|Sarcopenia|Muscle Weakness
Interventions: OTHER: Demographic information form|DIAGNOSTIC_TEST: widespread pain index (WPI)|DIAGNOSTIC_TEST: symptom severity scale (SSS)|DIAGNOSTIC_TEST: Fibromyalgia Impact Questionnaire (FIQ)|DIAGNOSTIC_TEST: Tender Point examination|OTHER: Muscle Architecture visualized with ultrasound|OTHER: Sarcopenia assessed by measuring isometric strengths of different parts of the body|OTHER: Timed Up & Go (TUG)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Glucose/Insulin Responses:Subjects With Type 2 Diabetes Consuming Diabetes-Specific vs Standard Nutritional Formulas
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: OTHER: Adult enteral formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardio-cerebrovascular Disease and Aspirin Ulcer Relapse Evaluation
Status: COMPLETED
Conditions: Cardio-cerebrovascular Disease
Interventions: DRUG: Low-dose PPI (Rabeprazole sodium)|DRUG: High-dose PPI (Rabeprazole sodium)|DRUG: Non-PPI (Gefarnate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Determinism of the Mechanism of Action of Specific Immunotherapy in Hymenoptera Venom Allergy
Status: COMPLETED
Conditions: Hymenoptera Allergy
Interventions: PROCEDURE: biological sampling|BIOLOGICAL: Desensitization protocol (Alyostall®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence Study of Torrent Pharmaceutical Ltd.'s Olanzapine Orally Disintegrating 5mg Tablets Under Fasting Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Olanzapine Orally Disintegrating Tablets 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Radiotherapy & Olaparib in COmbination for Carcinoma of the Oesophagus
Status: UNKNOWN
Conditions: Carcinoma of the Oesophagus
Interventions: DRUG: Olaparib|RADIATION: Radical external beam radiotherapy, 50Gy in 25 fractions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Relugolix Alone and Relugolix Combined With Hormonal Add-Back Therapy in Healthy Premenopausal Female Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Relugolix|DRUG: E2/NETA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tildrakizumab in the Treatment of Scalp Psoriasis
Status: COMPLETED
Conditions: Scalp Psoriasis
Interventions: DRUG: PART 1: Double-blind Placebo-controlled|DRUG: PART 2: Double-blind Active Treatment Extension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Emotions in Schizophrenia and Bipolar Disorders: a Common Vulnerability?
Status: UNKNOWN
Conditions: Bipolar Disorder|Schizophrenia
Interventions: OTHER: Electroencephalographic recordings|OTHER: neuropsychological evaluation|OTHER: clinical evaluation of symptoms
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Manicaland VMMC Uptake Through Behavioural Incentives Trial
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: BEHAVIORAL: Education session with fixed incentive|BEHAVIORAL: Education session with lottery incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Study of a Smartphone-Linked Self-Monitoring System Versus a Traditional One for Improving Metabolic Control and Compliance to Self-Monitoring of Blood Glucose
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: iBGStar|DEVICE: Traditional Glucometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Can Therapy Alter CNS Processing of Chronic Pain: A Longitudinal Study
Status: UNKNOWN
Conditions: Chronic Pain
Interventions: BEHAVIORAL: Group Cognitive Behavioral Therapy|BEHAVIORAL: Pain Education|BEHAVIORAL: Therapeutic Interactive Voice Response|BEHAVIORAL: NO TIVR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Cataract Pupillary Dilation: Inpatient At The Ambulatory Surgery Center vs Outpatient Dilation Prior To Arrival At The Ambulatory Surgery Center
Status: COMPLETED
Conditions: Pupil Dilation Prior to Cataract Surgery In-patient|Pupil Dilation Prior to Cataract Surgery Out-patient
Interventions: OTHER: Pupil dilation with phenylephrine 10% vs cyclopentolate 2%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Open-Label Extension of LOCKCYST Trial
Status: UNKNOWN
Conditions: Polycystic Liver Disease|Hepatomegaly|Liver Diseases|Polycystic Kidney|Autosomal Dominant
Interventions: DRUG: lanreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Busulfan and Cyclophosphamide Instead of Total Boby Irradiation (TBI) and Cyclophosphamide for Hematological Malignancies Hematocrit (HCT)
Status: UNKNOWN
Conditions: Acute Leukemias|Chronic Leukemias|Myelodysplastic Syndrome|Juvenile Myelomonocytic Leukemia
Interventions: DRUG: Busulfan/Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Early Pharmacodynamics of Single Rising Oral Doses of BI 1021958 Tablets in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1021958|DRUG: BI 1021958|DRUG: Placebo to BI 1021958
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Cutaneous Lupus Erythematosus (CLE) With the 595 nm Flashlamp Pulsed Dye Laser
Status: COMPLETED
Conditions: Cutaneous Lupus Erythematosus
Interventions: PROCEDURE: laser treatment (Candela Vbeam Perfecta™)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hydrolyzed Collagen Formulation vs Placebo in Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Collagen|PROCEDURE: Placebo (saline solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HIFLO ENDO-High Flow Nasal Cannula in GI Endoscopy
Status: COMPLETED
Conditions: Anesthesia Morbidity
Interventions: DEVICE: High flow nasal cannula oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: XB2001 in Combination With ONIVYDE + 5-FU/LV (+Folinic Acid) in Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: XB2001 or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Tolerability Study of SCH 721015 in Patients With Transitional Cell Carcinoma of the Bladder (Study P03816)
Status: COMPLETED
Conditions: Bladder Neoplasms
Interventions: GENETIC: SCH 721015 with SCH 209702
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiologic Effects of Steroids in Cardiac Arrest
Status: COMPLETED
Conditions: Inhospital Cardiac Arrest
Interventions: DRUG: Methylprednisolone; hydrocortisone|DRUG: Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of the Bioavailability of OZ439 When Delivered Directly to the Small Intestine, or Via the Oral Route
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: OZ439 120mg PIB|DRUG: 120 mg OZ439 caplet|DRUG: 120mg OZ439 caplet via Enterion capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pembrolizumab and Radiation Therapy in Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: ISS Stage I Plasma Cell Myeloma|ISS Stage II Plasma Cell Myeloma|ISS Stage III Plasma Cell Myeloma|Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: BIOLOGICAL: Pembrolizumab|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extending the Time Window for Tenecteplase by Effective Reperfusion in Patients With Large Vessel Occlusion
Status: RECRUITING
Conditions: Ischemic Stroke
Interventions: DRUG: Tenecteplase|DRUG: Standard Care (which may include intravenous Alteplase)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Active Surveillance Plus (AS+): High-intensity Focused Ultrasound (HIFU) in Patients With Localized Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: PROCEDURE: high-intensity focused ultrasound, HIFU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atorvastatin Pre-Treatment Study In Asian Patients With Acute Coronary Syndrome
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Atorvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The PreventIT Trial in Young Older Adults, Comparing Two Lifestyle-integrated Exercise Interventions
Status: COMPLETED
Conditions: Young Older Adults
Interventions: BEHAVIORAL: aLIFE|BEHAVIORAL: eLIFE|BEHAVIORAL: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate Electrocardiographic Effects of Therapeutic & Supratherapeutic Doses of Cytisinicline in Healthy Smokers
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Cytisinicline|DRUG: Placebo|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Umbilical Cord Abnormalities in the Prediction of Adverse Pregnancy Outcomes
Status: RECRUITING
Conditions: Small for Gestational Age at Delivery|Hypoxic-Ischemic Encephalopathy|Stillbirth|Admission to Neonatal Unit
Interventions: OTHER: Umbilical cord measurements & observations
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Arthroscopic Bankart Repair on Anterior-posterior Glenohumeral Translation and Shoulder Proprioception in Patients With Traumatic Anterior Shoulder Instability: a Prospective Cohort Study
Status: RECRUITING
Conditions: Shoulder Dislocation
Interventions: PROCEDURE: Arthroscopic Bankart repair
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Momordica Charantia Supplementation on Blood Glucose Levels
Status: COMPLETED
Conditions: Glucose Intolerance
Interventions: DIETARY_SUPPLEMENT: dried bitter-gourd supplements|DIETARY_SUPPLEMENT: dried cucumber supplements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of ChimeriVax™ Dengue Tetravalent Vaccine in Adult Subjects
Status: COMPLETED
Conditions: Dengue|Dengue Fever|Dengue Hemorrhagic Fever|Dengue Virus
Interventions: BIOLOGICAL: Chimeric dengue serotype (1, 2, 3, 4)|BIOLOGICAL: Chimeric dengue serotype (1, 2, 3, 4)|BIOLOGICAL: Chimeric dengue serotype (1, 2, 3, 4)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Use of Electrical Impedence to Measure Lean Body Weight as a Determinant of the Dose of Contrast Media for Abdominal CT
Status: COMPLETED
Conditions: IV Contrast Dosing
Interventions: DRUG: Isovue 370|OTHER: Weight calculation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Comparing Ropivacaine Adductor Canal Blockade by Surgeon Versus Anesthesiologist
Status: UNKNOWN
Conditions: Pain, Postoperative|Satisfaction
Interventions: DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: REmote moBile Outpatient mOnitoring in Transplant 2.0
Status: NOT_YET_RECRUITING
Conditions: Solid Organ Transplant|Heart Transplant|Liver Transplant|Kidney Transplant
Interventions: OTHER: Active communication through Reboot application|OTHER: Generic communication through Reboot application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: DMBSS-A Randomized Trial of Different Laparoscopic Gastric Bypass Surgery in Patients With Obesity-related T2DM
Status: UNKNOWN
Conditions: Diabetes Mellitus Type 2 in Obese
Interventions: PROCEDURE: LMGB|PROCEDURE: LRYGB|PROCEDURE: SADJB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Hydrolyzed Collagen Combined With Djulis and Green Caviar Improve Skin Condition
Status: COMPLETED
Conditions: Skin Condition
Interventions: DIETARY_SUPPLEMENT: placebo group|DIETARY_SUPPLEMENT: collagen drinkss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigational Drug, Crizotinib (PF-02341066), Is Being Studied In Tumors, Except Non-Small Cell Lung Cancer, That Are Positive For Anaplastic Lymphoma Kinase (ALK)
Status: TERMINATED
Conditions: Neoplasms Malignant
Interventions: DRUG: Crizotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rosuvastatin Adherence App Study in China
Status: COMPLETED
Conditions: Dyslipidemia|Hyperlipidemia
Interventions: OTHER: Smart phone based patient support tool|OTHER: Control application: only for data collection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment With Bendamustine, Ofatumumab and MethylPrednisolone in Relapsed B-CLL
Status: TERMINATED
Conditions: B-cell Chronic Lymphocytic Leukemia (B-CLL)
Interventions: DRUG: BOMP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short and Long Time Effects of IASTM and Myofascial Release Techniques in Chronic Neck Pain
Status: COMPLETED
Conditions: Chronic Neck Pain
Interventions: OTHER: IASTM|OTHER: Myofascial Release|OTHER: 250W infrared application|DEVICE: TENS|OTHER: Home exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Boosting Study for the SARS-CoV-2 rS Variant Vaccines
Status: COMPLETED
Conditions: COVID-19|SARS CoV 2 Infection
Interventions: DRUG: NVX-CoV2515|DRUG: NVX-Cov2373|DRUG: NVX-CoV2373 + NVX-CoV2515|DRUG: NVX-CoV2540|DRUG: NVX-CoV2373 + NVX-CoV2540
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: HEC53856 Phase 1 Study - Single and Multiple Oral Dosing in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HEC53856|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Lifestyle Changes on Erectile Dysfunction in Obese Men: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: BEHAVIORAL: Lifestyle - detailed advice|BEHAVIORAL: Control - general information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Goal-directed Therapy and Myocardial Dysfunction
Status: UNKNOWN
Conditions: Sepsis|Septic Shock|Myocardial Dysfunction
Interventions: OTHER: Early Goal Directed Hemodynamic Therapy in Sepsis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Evaluation and Tolerability of Dry Powder Tobramycin by a Novel Device in Patients With Non Cystic Fibrosis Bronchiectasis
Status: COMPLETED
Conditions: Bronchiectasis
Interventions: DRUG: Tobramycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Denosumab on Bone Fusion in Osteoporotic Patients After Lumbar Fusion
Status: UNKNOWN
Conditions: Osteoporosis|Fusion of Spine, Lumbar Region
Interventions: DRUG: Denosumab 60 mg/ml Injectable Solution [Prolia]|DRUG: calcium and vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Practices and Locally Advanced Lung Cancer (LUNGDIET)
Status: NOT_YET_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: BEHAVIORAL: Self-administered survey at hospital|BIOLOGICAL: Blood sample for nutritional assessment|OTHER: Consultation with nutritionist doctor and dietician
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neuroimaging Study of Risk Factors for Adolescent Bipolar Disorder
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: mixed amphetamine salts-extended release (MAS-XR)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Acetazolamide in Patients With Acute Heart Failure
Status: UNKNOWN
Conditions: Heart Failure|Acute Heart Failure
Interventions: DRUG: Acetazolamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LCZ696 Compared to Valsartan in Patients With Chronic Heart Failure and Preserved Left-ventricular Ejection Fraction
Status: COMPLETED
Conditions: Chronic Heart Failure
Interventions: DRUG: LCZ696|DRUG: Valsartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Optimal Timing Of Primaquine To Prevent Malaria Transmission After Artemisinin-Combination Therapy
Status: UNKNOWN
Conditions: Malaria Transmission
Interventions: DRUG: Artemether Lumefantrine|DRUG: Artemether Lumefantrine 6 dose regimen & single dose of Primaquine on day 0|DRUG: Artemether Lumefantrine 6 dose regimen and single dose Primaquine on day 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Bilberry Fruit and Black Rice Derived Anthocyanins on Lipid Status
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DIETARY_SUPPLEMENT: Delphinidin type anthocyanins|DIETARY_SUPPLEMENT: Cyanidin type anthocyanins|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: TAP Versus Thoracic Epidural in Major Abdominal Resections
Status: COMPLETED
Conditions: Malignant Neoplasm of Abdomen|Surgery
Interventions: DRUG: Exparel 1.33% (20ml Volume)|DRUG: 0.125% bupivicaine with 2 mcg/ml Fentanyl.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Investigation of Recovery Following Hip Resurfacing or Total Hip Arthroplasty
Status: WITHDRAWN
Conditions: Osteoarthritis|Rheumatoid Arthritis|Arthritis|Traumatic Arthritis
Interventions: DEVICE: Hip Resurfacing System|DEVICE: M2a-Magnum™ Large Metal Articulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Gentle Biopsy Method of Cervix Lesions Using Superficial Curettage/Protocol ID: CX-CUR
Status: UNKNOWN
Conditions: CIN|Cervical Cancer
Interventions: PROCEDURE: conventional cervix biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dose Escalation Study With MK-2206 in Patients With Locally Advanced or Metastatic Solid Tumors (MK-2206-002)
Status: COMPLETED
Conditions: Locally Advanced Tumors|Metastatic Solid Tumors|Cancer|Neoplasms
Interventions: DRUG: MK-2206
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Fixture Thread Depth on Accuracy of Immediate Implant Placement Using Dynamic Navigation
Status: NOT_YET_RECRUITING
Conditions: Tooth Loss|Partial-edentulism
Interventions: DEVICE: Straumann BLX implant|DEVICE: Straumann BLT implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Folate Supplementation in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Folate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: YN001 in Healthy Subjects and Patients With Coronary Atherosclerosis
Status: RECRUITING
Conditions: Atherosclerotic Cardiovascular Disease
Interventions: DRUG: YN001|DRUG: Placebo for YN001|DRUG: rosuvastatin calcium tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Drink Composition on the Appearance of Ingested Water in Body Fluids
Status: COMPLETED
Conditions: Rate of Water Appearance/Delivery in the Blood|Water Balance
Interventions: OTHER: Composition of Sports Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety Study to Evaluate the Occurrence of EFAD in Pediatric Patients With PNAC Who Require More Than Eight Weeks of Omegaven Treatment
Status: NOT_YET_RECRUITING
Conditions: Parenteral Nutrition Associated Liver Disease (PNALD)|Essential Fatty Acid Deficiency|Malnutrition|Pediatric ALL
Interventions: DRUG: Omegaven® (fish oil triglycerides) Injectable Emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: LEFT ATRIAL MONITORING IN PATIENTS BEFORE AND AFTER MITRAL SURGERY - LAMBDA STUDY
Status: NOT_YET_RECRUITING
Conditions: Mitral Regurgitation|Mitral Valve Disease|Heart Failure
Interventions: OTHER: Mitral valve repair with creation of an 8 mm inter-atrial shunt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Transversus Abdominis Plane Block in Pediatrics: Volume or Concentration ?
Status: UNKNOWN
Conditions: Inguinal or Ovarian Hernia|Hydrocele|Cord Kyst|Local Analgesia Block|One to Five Years
Interventions: DRUG: Injection of 0,2 ml/kg of 0,2% levobupivacaine for small volume group|DRUG: Injection of 0,4 ml/kg of 0,1% lévobupivacaine for high volume group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: MRI Assessment of Mode of Action of Bisacodyl, Multiple Doses
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: Bisacodyl 5 milligram|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: FES and Upper Limb Loading Exercises Outcome Comparison on Hand Function in Spinal Cord Injury Patients
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: OTHER: Functional Electrical Stimulation|OTHER: Upper Limb Loading Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Child Health, Agriculture and Integrated Nutrition
Status: UNKNOWN
Conditions: Stunting
Interventions: DIETARY_SUPPLEMENT: Small-quantity lipid-based nutrient supplement|DIETARY_SUPPLEMENT: Provitamin A biofortified maize|DIETARY_SUPPLEMENT: NUA-45 biofortified sugar beans|DIETARY_SUPPLEMENT: Moringa oleifera|DIETARY_SUPPLEMENT: Whole egg powder|DIETARY_SUPPLEMENT: White maize meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Iberdomide Versus Observation Off Therapy After Idecabtagene Vicleucel CAR-T for Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Computed Tomography|DRUG: Iberdomide|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Patient Monitoring|PROCEDURE: Positron Emission Tomography|PROCEDURE: Skeletal Survey X-Ray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of the invisaRED® IR REHAB Device When Used as an Adjunctive Therapy for Nociceptive Musculoskeletal Pain
Status: NOT_YET_RECRUITING
Conditions: Nociceptive Pain|Musculoskeletal Pain
Interventions: DEVICE: IR REHAB|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of ZD6474 to Treat Multiple Myeloma Cancer
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: ZD6474|DRUG: VEGF-receptor tyrosine kinase (KDR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robotic Exoskeleton With Functional Electrical Stimulation in Acute Spinal Cord Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Ekso Training with FES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy Plus Temozolomide and Pembrolizumab With and Without HSPPC-96 in Newly Diagnosed Glioblastoma (GBM)
Status: TERMINATED
Conditions: Glioblastoma
Interventions: DRUG: Pembrolizumab|BIOLOGICAL: HSPPC-96|DRUG: Temozolomide|OTHER: Placebo|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metronomic Chemotherapy in Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Metastatic Gastric Cancer|Locally Advanced Gastric Cancer
Interventions: DRUG: Paclitaxel 60mg/m2, Oxaliplatin 50mg/m2, Leucovorin 20mg/m2, and 5-FU 425mg/m2 IV weekly
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Prebiotics on Function and Pain in Patients With Osteoarthritis and Obesity
Status: COMPLETED
Conditions: Osteo Arthritis Knee|Obesity
Interventions: DIETARY_SUPPLEMENT: Prebiotic oligofructose-enriched inulin|DIETARY_SUPPLEMENT: Placebo maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blood Management in Orthopedic Surgery
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: OTHER: erythropoietin and cell saver|DRUG: erythropoietin|DEVICE: OrthoPAT|DEVICE: Post-operative drain device|OTHER: Erythropoietin and OrthoPAT|OTHER: Erythropoietin and drain device|DEVICE: OrthoPAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi
Status: NOT_YET_RECRUITING
Conditions: Malaria,Falciparum|Anemia in Children
Interventions: DRUG: Dihydroartemisinin-Piperaquine|DRUG: Chloroquine|DRUG: Sulfadoxine pyrimethamine|DRUG: Sulfadoxine-pyrimethamine-amodiaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Early Stage Amyotrophic Lateral Sclerosis Phrenic Stimulation
Status: TERMINATED
Conditions: Amyotrophic Lateral Sclerosis|Respiratory Insufficiency
Interventions: DEVICE: phenique nerve stimulation NeurX™ (Synapse Biomedical)|DEVICE: sham phrenic nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effects of Physical Exercise to Prevent Osteoporosis in Postmenopausal Women
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal|Osteoporosis, Osteopenia|Physical Activity
Interventions: OTHER: walking at an intense pace|OTHER: osteoporosis specific-oriented training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuromolecular Risk Factors for Obesity (PROSPECT)
Status: UNKNOWN
Conditions: Obesity
Interventions: DIAGNOSTIC_TEST: fMRI imaging|DIAGNOSTIC_TEST: [11C]carfentanil PET scan|DIAGNOSTIC_TEST: [18F]FMPEP-d2 PET scan|DIAGNOSTIC_TEST: [18F]-FDG PET scan|DIAGNOSTIC_TEST: Physical activity measures and fitness tests|DIAGNOSTIC_TEST: Laboratory measurements|DIAGNOSTIC_TEST: Questionnaires|DIAGNOSTIC_TEST: Hyperinsulinemic euglycemic clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: FAPI PET for Response Evaluation and Prognosis Prediction in Liver and Biliary Cancer Patients Treated With PD-1 Combination Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma|Bile Duct Cancer
Interventions: DIAGNOSTIC_TEST: [68Ga]FAPI PET/CT and [18F]FDG PET/CT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Anti-HER2 Therapy in Patients of HER2 Positive Metastatic Carcinoma of Digestive System
Status: UNKNOWN
Conditions: Targeted Therapy|HER2|Biliary Tract Cancer|Esophageal Squamous Cell Carcinoma|Colorectal Cancer
Interventions: DRUG: chemotherapy in combination with trastuzumab for arm1|DRUG: chemotherapy in combination with trastuzumab for arm2|DRUG: chemotherapy in combination with trastuzumab for arm3|DRUG: chemotherapy in combination with trastuzumab for arm4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Cranial Electrotherapy Stimulation as an Add-on Treatment for Tic Disorders (SCATT)
Status: UNKNOWN
Conditions: Tic Disorder, Childhood
Interventions: DEVICE: Cranial Electrotherapy Stimulation(CES)|DEVICE: sham Cranial Electrotherapy Stimulation( sham CES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sarilumab COVID-19
Status: COMPLETED
Conditions: Corona Virus Infection
Interventions: DRUG: Sarilumab SAR153191|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Epitope Peptide To Treat HLA-A*24 or A*02-positive Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: BIOLOGICAL: HLA-A*2402 or A*0201 restricted peptides
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclosporine and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Leukemia
Interventions: DRUG: cyclosporine|DRUG: etoposide|DRUG: mitoxantrone hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Open-Label Study of the CDK4/6 Inhibitor SPH4336 in Subjects With Locally Advanced or Metastatic Liposarcomas
Status: RECRUITING
Conditions: Liposarcoma, Dedifferentiated
Interventions: DRUG: SPH4336
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Finding Safety and Efficacy Trial of Org 50081 (Esmirtazapine) in the Treatment of Vasomotor Symptoms (177001/P06472/MK-8265-013)
Status: COMPLETED
Conditions: Postmenopausal Symptoms|Menopause|Vasomotor Symptoms
Interventions: DRUG: Esmirtazapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors
Status: COMPLETED
Conditions: Melanoma|Breast Carcinoma|Hepatocellular Carcinoma|Urothelial Carcinoma|Squamous Cell Carcinoma of the Head and Neck|Renal Cell Carcinoma|Colorectal Carcinoma|Non-small Cell Lung Carcinoma|Gastric or Gastroesophageal Junction Adenocarcinoma|Endometrial Carcinoma|Mesothelioma|Neuroendocrine Carcinoma|Cervical Cancer|Small Cell Lung Carcinoma|Squamous Cell Carcinoma of the Anus|Castration-Resistant Prostate Carcinoma|Nasopharyngeal Carcinoma|Cholangiocarcinoma|Basal Cell Carcinoma|Ovarian Carcinoma|Fallopian Tube Carcinoma|Thymoma|Thymic Carcinoma|Squamous Cell Carcinoma of the Penis|Vulvar Carcinoma|Solid Tumors With Published Evidence of Anti-tumor Activity With Anti-PD1/PDL1 and/or Anti-CTLA4-directed Therapy|Malignant Adnexal Neoplasms|Non-squamous Cell Salivary Gland Carcinoma
Interventions: BIOLOGICAL: XmAb20717
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Investigate 18F-AzaFol in the Diagnosis of Large Vessel Vasculitis
Status: NOT_YET_RECRUITING
Conditions: Giant Cell Arteritis
Interventions: DRUG: AzaFol|DRUG: FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vildagliptin and Endothelium-dependent Vasodilatation
Status: COMPLETED
Conditions: Type 2 Diabetes|Endothelial Dysfunction
Interventions: DRUG: vildagliptin + acarbose|DRUG: acarbose + vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: uPAR PET/CT in Radium-223-dichloride Treatment of Patients With Metastatic Castration-resistant Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer Metastatic|Bone Metastases
Interventions: DRUG: Injection of PET tracer 68Ga-NOTA-AE105|DEVICE: PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial of the Modified Atkins Diet in Infantile Spasms Refractory to Hormonal Therapy
Status: WITHDRAWN
Conditions: Infantile Spasms
Interventions: BEHAVIORAL: modified Atkins diet|OTHER: no dietetic input
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Immunogenicity Study of a 31-Valent Pneumococcal Conjugate Vaccine (VAX-31) in Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Pneumococcal Vaccines
Interventions: BIOLOGICAL: 31 valent pneumococcal conjugate vaccine|BIOLOGICAL: 20 valent pneumococcal conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION