pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Impact of Immediate Point-of-Care Ultrasound on Patients With Cardiopulmonary Symptoms in the Emergency Department
Status: COMPLETED
Conditions: Chest Pain|Dyspnea|Syncope|Hypotension
Interventions: OTHER: Point-of-care ultrasound|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Radicular Dentin Remaining, Risk of Perforation and Canal Transportation in Manual Versus Rotary Instrumentation in Primary Molars
Status: COMPLETED
Conditions: Root Canal Infection
Interventions: OTHER: Endodontic files
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Sodium Nitrite on Renal Function and Blood Pressure in Healthy Humans. A Dose-response Study
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Sodium nitrite, 40 micrograms/kg/hour|DRUG: Sodium nitrite, 120 micrograms/kg/hour|DRUG: Sodium nitrite, 240 micrograms/kg/hour|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intact Liver Innervation and Glucose and Glucagon-like Peptide-1 (GLP-1) Induced Insulin Secretion
Status: UNKNOWN
Conditions: Liver Transplantation
Interventions: DRUG: dipeptidyl peptidase 4 (DPP4) inhibitor|OTHER: oral glucose|OTHER: intravenous glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of da Vinci Simulator vs LapSim Simulator
Status: WITHDRAWN
Conditions: Laparoscopy Training|Robotic Surgery Training
Interventions: OTHER: da Vinci Skills Simulator®|OTHER: LapSim®|OTHER: Dry lab box laparoscopic training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD
Status: COMPLETED
Conditions: PTSD|Alcohol Use Disorder
Interventions: DRUG: Pregabalin plus BBCET|OTHER: Placebo plus BBCET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Deferasirox Combination Treatment With Deferiprone In Thalassaemia Patients
Status: COMPLETED
Conditions: Beta-thalassemia Major
Interventions: DRUG: DFX(Deferasirox)|DRUG: DFP(Deferiprone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Cervical Spinal Stabilization Exercise Programs by Magnetic Resonance Imaging in Healthy Individuals
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Exercises focused on flexor muscles|OTHER: Exercises focused on extensor muscles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nab-paclitaxel Plus S-1(AS) Versus Nab-paclitaxel Plus Gemcitabine(AG) in Patients With Advanced Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: DRUG: nanoparticle albumin-bound paclitaxel|DRUG: S1|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Adjunctive Exercise for the Behavioral Treatment of Major Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: BEHAVIORAL: Behavioral Activation|BEHAVIORAL: Exercise Intervention|BEHAVIORAL: Stretching Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High On-treatment Platelet Reactivity Identified by Multiple Platelet Function Assay
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Clopidogrel|DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of the Source and Food Matrices on the Bioavailability of Peptan® (Collagen Peptides) in Healthy Subjects
Status: COMPLETED
Conditions: Bioavailability
Interventions: DIETARY_SUPPLEMENT: collagen peptides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Paired Associative Stimulation in Methamphetamine Addiction
Status: UNKNOWN
Conditions: Methamphetamine-dependence
Interventions: DEVICE: MagPro X100 device (MagVenture, Farum, Denmark)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A 12-week Study of Pramipexole Extended Release (ER) in Patients With Parkinson's Disease (PD), Followed by a 52-week Long-term Treatment Period
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Pramipexole Immediate Release|DRUG: Pramipexole Extended Release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EUS-guided Gallbladder Drainage Instead of Laparoscopic Cholecystectomy for Acute Cholecystitis. A Feasibility Study.
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Cholecystitis
Interventions: DEVICE: EUS-guided gallbladder drainage (EGBD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Six-Month Randomized Controlled Trial (RCT) of Probuphine Safety and Efficacy in Opioid Addiction
Status: COMPLETED
Conditions: Opioid Dependency
Interventions: DRUG: Probuphine (buprenorphine implant)|DRUG: placebo implant|DRUG: Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vectron T500 (Broflanilide 50WP) for IRS in Tanzania Tanzania
Status: UNKNOWN
Conditions: Malaria,Falciparum
Interventions: OTHER: IRS insecticide: Vectron T500
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: An Evaluation of Potential Next-day Residual Effects of Eszopiclone in Healthy Volunteers.
Status: COMPLETED
Conditions: Healthy Subjects|Sleep Initiation and Maintenance Disorders
Interventions: DRUG: GSK1755165; placebo; zopiclone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Monopolar Scissors vs Bipolar Vessel Sealer vs Ultrasonic Shears: A Prospective Randomized Study in Laparoscopic Colorectal Surgery
Status: COMPLETED
Conditions: Colorectal Disease
Interventions: DEVICE: Laparoscopic colectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Personal Digital Assistant (PDA) - Based Dietary Adherence Intervention on Interdialytic Weight Gain and Blood Pressure in Hemodialysis Patients
Status: COMPLETED
Conditions: End-Stage Renal Disease
Interventions: BEHAVIORAL: Standard hemodialysis dietary instruction|BEHAVIORAL: Behavioral counseling plus PDA-based self-monitoring of diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Study of MLN2480 in Participants With Relapsed or Refractory Solid Tumors Followed by a Dose Expansion in Participants With Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma|Metastatic Melanoma|Solid Tumor|Neoplasm
Interventions: DRUG: MLN2480
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Corneal Incision Versus Toric Intraocular Lens Techniques Used in Cataract Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Cataract Surgery
Interventions: DIAGNOSTIC_TEST: Corneal Incision|OTHER: Toric Intraocular
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy of Two Regimens of Ranibizumab 0.5 mg in Chinese Patients With Neovascular AMD
Status: UNKNOWN
Conditions: Neovascular Age-related Macular Degeneration
Interventions: PROCEDURE: 1+PRN|PROCEDURE: 3+PRN|DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Zephyr Valve System With Inter-lobar Fissure Completion for Lung Volume Reduction in Emphysema
Status: RECRUITING
Conditions: Emphysema or COPD
Interventions: PROCEDURE: Robotic or VATS lobar fissure completion|DEVICE: Endobronchial valves placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Communication Issues in Patient and Provider Discussions of Immunotherapy
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid System Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Educational video|OTHER: Interview|OTHER: Observation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Empagliflozin vs Metformin on Metabolic Dysfunction in Polycystic Ovary Syndrome With or Without Comorbidity or Multimorbidity
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Weight Gain|HbA1c
Interventions: DRUG: Empagliflozin 10 MG|DRUG: MetFORMIN 500 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Immune Responses After Vaccination Against Seasonal Influenza Virus and Against Influenza H1N1-v Pandemic Virus in a Medical Staff.
Status: UNKNOWN
Conditions: Influenza A Virus, H1N1 Subtype
Interventions: BIOLOGICAL: Anti-H1N1v Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multiple Dose Study In Treatment Naive Subjects Infected With Hepatitis C Virus
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: BMS-824393|DRUG: BMS-824393|DRUG: BMS-824393|DRUG: BMS-824393|DRUG: BMS-824393
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunization of Patients With Non Small Cell Lung Cancer (NSCLC)
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer (NSCLC)
Interventions: BIOLOGICAL: semi-allogeneic human fibroblasts (MRC-5) transfected with DNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: YQ23 Study in Patients With Critical Limb Ischaemia
Status: TERMINATED
Conditions: Critical Limb Ischemia
Interventions: BIOLOGICAL: YQ23|BIOLOGICAL: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sleeve Gastrectomy With Cruroplasty and Omental Rape for Treatment of Morbid Obesity With Reflux Disease
Status: COMPLETED
Conditions: Obesity, Morbid|GERD
Interventions: PROCEDURE: sleeve gastrectomy+ cruroplasty+ omental rap
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Bracket Bonding Variables Using 3D Printed Bonding Guide Versus Digital Indirect Bonding
Status: RECRUITING
Conditions: Dental Bonding|Orthodontic Brackets|Indirect Bonding
Interventions: DEVICE: Windowed Bonding|DEVICE: Digital Indirect bonding tray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of JNJ-56021927 When Taken Orally as Tablet Formulation in Healthy Male Japanese Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-56021927 60 Milligram|DRUG: JNJ-56021927 120 Milligram|DRUG: JNJ-56021927 240 Milligram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Doxil & Carboplatin Plus HER2+ in Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Pegylated liposomal doxorubicin|DRUG: Carboplatin|DRUG: trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acceptability and Safety of Switching From Subutex or Other Opioid Drug Dependence Therapy to Suboxone (NIS P05444)
Status: COMPLETED
Conditions: Opioid-Related Disorders|Opiate Dependence|Drug Abuse
Interventions: DRUG: buprenorphine/naloxone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Alogliptin/Pioglitazone on the Preservation of Long-term Beta-cell Function
Status: UNKNOWN
Conditions: Diabetes
Interventions: DRUG: NESINA ACT TAB. 25/15mg|DRUG: AMARYL-M TAB. 2/500mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Besifovir in Adults With Normal and Impaired Renal Function
Status: UNKNOWN
Conditions: Renal Impairment
Interventions: DRUG: Besifovir Dipivoxil Maleate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study of the Combination of Lenalidomide (Revlimid®), Dexamethasone and Cyclophosphamide in Patients Refractory or Relapsing From Stable Disease With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy With or Without Bevacizumab in Treating Women With Stage I, Stage II, or Stage IIIA Breast Cancer That Can Be Removed By Surgery
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: capecitabine|DRUG: cyclophosphamide|DRUG: docetaxel|DRUG: doxorubicin hydrochloride (Adriamycin)|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Bone Marrow Mesenchymal Stem Cells (BMSCs) Transplantation in the Treatment of Ischemic Stroke
Status: RECRUITING
Conditions: Ischemic Stroke
Interventions: BIOLOGICAL: Transplantation of self BMSCs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amino Acid Nutrition in the Critically-ill
Status: RECRUITING
Conditions: Critical Illness|Inflammation|Malnutrition
Interventions: DIETARY_SUPPLEMENT: Peptamen 1.5% via enteral|DIETARY_SUPPLEMENT: Prosol 20% IV to 1.75g/kg/day|DIETARY_SUPPLEMENT: Prosol 20% IV to 2.5g/kg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: RxSight Light Adjustable Lens and Light Delivery Device New Enrollment Study
Status: RECRUITING
Conditions: Aphakia|Cataract
Interventions: DEVICE: Light Adjustable lens (LAL) and Light Delivery Device (LDD)|DEVICE: Control IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Function Using the RF Microstimulator Gait System Following Stroke 2008
Status: TERMINATED
Conditions: Stroke
Interventions: DEVICE: radio frequency-controlled (RF) Microstimulator (RFM) Gait System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of SHR6508 in Secondary Hyperparathyroidism
Status: COMPLETED
Conditions: Secondary Hyperparathyroidism
Interventions: DRUG: SHR6508；Placebo|DRUG: SHR6508；Placebo|DRUG: SHR6508；Placebo|DRUG: SHR6508；Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of CFT in Individuals With CNLBP
Status: COMPLETED
Conditions: Chronic Pain|Neuropathic Low Back Pain
Interventions: OTHER: Cognitive Functional Therapy|OTHER: Exercise program:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repeat Insult Patch Test of Skin Irritation/Sensitization for Cetaphil Dermacontrol Oil Control Moisturizer SPF 30
Status: COMPLETED
Conditions: Skin Irritation
Interventions: OTHER: Cetaphil DermaControl Oil Control Moisturizer SPF 30
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Advanced Pelvic Floor Training Program for Prostate Cancer Surgery
Status: COMPLETED
Conditions: Prostate Cancer Patients Undergoing Radical Prostatectomy
Interventions: BEHAVIORAL: Advanced Pelvic Floor Muscle Exercise (APFX)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Increasing Neonatal HIV Test and Treat to Maximize the Long-Term Impact on Infant Health and Novel Infant Antiretroviral Treatment
Status: NOT_YET_RECRUITING
Conditions: Vertical Human Immunodeficiency Virus Transmission|HIV Infection Pediatric|Infant Death|Infant Morbidity|Infant, Newborn, Diseases
Interventions: PROCEDURE: Maternal HIV viral load testing at delivery for VHT risk assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A First Time in Human Study to Evaluate the Safety and Tolerability of GSK4381406 in Healthy Participants
Status: WITHDRAWN
Conditions: Colitis, Ulcerative
Interventions: DRUG: GSK4381406|DRUG: Placebo|DRUG: Indomethacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: uPAR PET/CT and FDG PET/MRI for Preoperative Staging of Bladder Cancer
Status: UNKNOWN
Conditions: Urinary Bladder Neoplasms
Interventions: DRUG: Injection of 68Ga-NOTA-AE105|DRUG: Injection of 18F-FDG|DEVICE: Positron Emission Tomography and CT|DEVICE: Positron Emission Tomography and MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis
Status: COMPLETED
Conditions: Histoplasmosis|Sporotrichosis|Blastomycosis
Interventions: DRUG: fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Peripheral Blood Stem Cell Transplantation for Hematologic Malignancies With Alpha Beta TCell and B Cell Depletion Using the CliniMACS Device
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematologic Malignancies
Interventions: BIOLOGICAL: CliniMACs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Perinatal Health Promotion Program on the Different Levels of Gestational Hyperglycemic Women
Status: TERMINATED
Conditions: Gestational Diabetes
Interventions: BEHAVIORAL: Perinatal health promotion program and regular prenatal care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of the Safety and Tolerability of L-DLPFC iTBS rTMS for MDD in MS
Status: RECRUITING
Conditions: Multiple Sclerosis|Major Depressive Disorder
Interventions: DEVICE: Repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Mesotherapy With Minoxidil 0.5%/2ml for Androgenetic Alopecia in Female Patients
Status: UNKNOWN
Conditions: Female Pattern Alopecia
Interventions: DRUG: Minoxidil|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Osimertinib in Treatment-naïve Patients With EGFR Mutant NSCLC According to TP53 Mutational Status.
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Booster Dose of Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children
Status: COMPLETED
Conditions: EV71-associated Disease
Interventions: BIOLOGICAL: alum-adjuvant 160U /0.5ml|BIOLOGICAL: alum-adjuvant 320U /0.5ml|BIOLOGICAL: alum-adjuvant 640U /0.5ml|BIOLOGICAL: adjuvant-free 640U /0.5ml|BIOLOGICAL: 0/0.5ml placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Nerve Block Anesthesia for Surgery of Hip Fracture in the Elderly
Status: UNKNOWN
Conditions: Anesthesia; Reaction
Interventions: PROCEDURE: paravertebral nerve|PROCEDURE: lumbar and sacral plexus block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: DT2219ARL for Relapsed or Refractory CD19 (+), CD 22 (+) B-Lineage Leukemia Or Lymphoma
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: DT2219ARL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Equine Antibody Treatment in Patients With COVID 19 Infection
Status: TERMINATED
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: Equine COVID-19 Antiserum|DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study to Assess the Safety and Efficacy of Prograf vs Prograf-XL in de Novo Liver Transplant Recipients.
Status: COMPLETED
Conditions: Liver Transplantation|Transplantation Immunology|Host vs Graft Reaction
Interventions: DRUG: Prograf-XL|DRUG: Prograf|DRUG: MMF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sepsis Associated Encephalopathy (SAE) Biomarkers
Status: ACTIVE_NOT_RECRUITING
Conditions: Sepsis|Altered Mental Status|Sepsis-Associated Delirium|Sepsis Associated Encephalopathy|Delirium, Sepsis Associated
Interventions: PROCEDURE: Blood draws
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Efficacy and Safety Study Of Pracinostat In Combination With Azacitidine In Adults With Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Pracinostat|DRUG: Placebos|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Belatacept Pilot Study in Lung Transplantation Immunosuppression in Lung Transplantation
Status: COMPLETED
Conditions: Lung Transplant Rejection|Antibody-mediated Rejection
Interventions: DRUG: Belatacept|DRUG: Tacrolimus|DRUG: ATG|DRUG: Mycophenolate Mofetil|DRUG: Methylprednisolone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction
Status: COMPLETED
Conditions: Thyroid Dysfunction|Bone Mineral Density|Osteoporosis|Fractures, Bone
Interventions: DRUG: Levothyroxine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate Tolerability and Pharmacokinetics of HL217 Eye Drop in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Subject
Interventions: DRUG: Cohort 1: HL217 Ophathalmic Solution QD|DRUG: Cohort 2: HL217 Ophathalmic Solution BID|DRUG: Cohort 3: HL217 Ophthalmic Solution QID|DRUG: Placebo Ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Warming Garment in the Perioperative Period With Integrated Chemical Heat Packs to Maintain Normothermia
Status: COMPLETED
Conditions: Hypothermia
Interventions: DEVICE: Air-Activated heating packs|DEVICE: Forced Air Warming Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Visual Function After Bilateral Implantation of EDOF IOLs
Status: COMPLETED
Conditions: Cataract Bilateral|Lens, Intraocular|Lens Implantation, Intraocular|Pseudophakia|Visual Acuity
Interventions: DEVICE: Acunex Vario intraocular lens|DEVICE: Alcon AcrySof IQ Vivity intraocular lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of MT-5547 in Patients With Osteoarthritis Accompanied by Moderate to Severe Pain
Status: COMPLETED
Conditions: Osteoarthritis, Knee / Osteoarthritis, Hip
Interventions: DRUG: MT-5547|DRUG: MT-5547-matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Precision Application of Clostridium Butyricm of Clinical Research on Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis|Knee
Interventions: BEHAVIORAL: Western Ontario and McMaster University Osteoarthritis Index (WOMAC)|BEHAVIORAL: Visual Analogue Scale (VAS)|DIAGNOSTIC_TEST: Kellgren Lawrence Grading Scale (KL score)|BEHAVIORAL: Quality of Life Questionnaires and Assessments:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study in the Prevention of Antibiotic-Associated Diarrhea (AAD) and Clostridium Difficile-Associated Diarrhea (CDAD) in Hospitalized Adult Patients Exposed to Nosocomial Infection
Status: COMPLETED
Conditions: Antibiotic-Associated Diarrhea|Clostridium Difficile-Associated Diarrhea
Interventions: OTHER: BIO-K+ CL-1285®|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: ART Restorations With High-viscosity Glass-ionomer Cement Versus Hall Technique in Primary Molars
Status: COMPLETED
Conditions: Primary Teeth Retained
Interventions: DRUG: High viscosity glass ionomer cement|DEVICE: Stainless steel crown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Benfotiamine and AGE on Endothelial Function in People With Diabetes
Status: COMPLETED
Conditions: Endothelial Dysfunction|Type 2 Diabetes Mellitus
Interventions: DRUG: Benfotiamine 1050mg, 3 days|BEHAVIORAL: high-AGE vs. low-AGE meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of an Explicit Approach
Status: RECRUITING
Conditions: Developmental Language Disorder|Explicit Intervention|Grammatical Language
Interventions: BEHAVIORAL: Implicit-only|BEHAVIORAL: Explicit-added
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Open-label Extension Trial With Rotigotine in Idiopathic Restless Legs Syndrome Subjects
Status: COMPLETED
Conditions: Idiopathic Restless Legs Syndrome
Interventions: DRUG: Rotigotine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrated Analysis of Therapy Response and Resistence in Embryonal Tumors and Gliomas
Status: NOT_YET_RECRUITING
Conditions: Glioma, Malignant|Embryonal Tumor|Medulloblastoma|Ependymoma
Interventions: DIAGNOSTIC_TEST: Tissue, blood, cerebrospinal-spinal fluid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Immunogenicity Study of Inactivated Vaccine for Prophylaxis of SARS CoV-2 Infection (COVID-19)
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Two doses of medium dosage inactivated SARS-CoV-2 vaccine at the emergency vaccination schedule|BIOLOGICAL: Two doses of high dosage inactivated SARS-CoV-2 vaccine at the emergency vaccination schedule|BIOLOGICAL: Two doses of placebo at the emergency vaccination schedule|BIOLOGICAL: Two doses of medium dosage inactivated SARS-CoV-2 vaccine at the routine vaccination schedule|BIOLOGICAL: Two doses of high dosage inactivated SARS-CoV-2 vaccine at the routine vaccination schedule|BIOLOGICAL: Two doses of placebo at the routine vaccination schedule|BIOLOGICAL: Three doses of medium dosage inactivated SARS-CoV-2 vaccine at the emergency vaccination schedule|BIOLOGICAL: Three doses of high dosage inactivated SARS-CoV-2 vaccine at the emergency vaccination schedule|BIOLOGICAL: Three doses of placebo at the emergency vaccination schedule|BIOLOGICAL: Three doses of medium dosage inactivated SARS-CoV-2 vaccine at the routine vaccination schedule|BIOLOGICAL: Three doses of high dosage inactivated SARS-CoV-2 vaccine at the routine vaccination schedule|BIOLOGICAL: Three doses of placebo at the routine vaccination schedule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 3 Study of TAS-205 in Patients With Duchenne Muscular Dystrophy（REACH-DMD）
Status: ACTIVE_NOT_RECRUITING
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: TAS-205 [Ambulatory Cohort] [Non-ambulatory Cohort]|DRUG: Placebo [Ambulatory Cohort] only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Fc-Optimized Anti-CD19 Antibody (MOR00208) to Treat Non-Hodgkin's Lymphoma (NHL)
Status: COMPLETED
Conditions: Non-Hodgkin Lymphoma
Interventions: DRUG: MOR00208 (formerly Xmab 5574)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Addition of Fentanyl or Dexamethasone or Both to Bupivacaine in Paravertebral Block for Patients Undergoing Major Breast Surgery
Status: UNKNOWN
Conditions: Paravertebral Block
Interventions: DRUG: Fentanyl|DRUG: Dexamethasone|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 3D Analysis of Cemento-Osseous Lesions
Status: COMPLETED
Conditions: Bone Diseases|Cone-beam Computed Tomography|Florid Cemento-osseous Dysplasia
Interventions: OTHER: The data of patients who had applied to the clinic for various reasons and were diagnosed with fibro-osseous lesions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Lot Consistency for RSVpreF in a Population of Healthy Adults 18 to ≤49 Years of Age
Status: COMPLETED
Conditions: RSV
Interventions: BIOLOGICAL: RSVpreF (Group 1)|BIOLOGICAL: RSVpreF (Group 2)|BIOLOGICAL: RSVpreF (Group 3)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Multiple-Dose Safety Study of Fixed Combination of Acetaminophen/Naproxen Sodium in Adolescents With Orthodontic Pain
Status: WITHDRAWN
Conditions: Orthodontic Pain
Interventions: DRUG: Acetaminophen/Naproxen Sodium Fixed Combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Tolerability of PT010, PT009 and PT003 in Subjects With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: BGF MDI 320/14.4/9.6 μg|DRUG: GFF MDI 14.4/9.6 μg|DRUG: BFF MDI 320/9.6 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: IVIG in Painful Sensory Neuropathy
Status: NOT_YET_RECRUITING
Conditions: Sensory Neuropathy|Small Fiber Neuropathy
Interventions: DRUG: Intravenous immunoglobulin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Molecular Imaging of FAP Expressing Cancer-associated Fibroblasts in NSCLC Treated With Immune-checkpoint Inhibitors
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: PROCEDURE: FAPI PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Specific Postural Corrective Exercises on EMG Activity in Patients With Forward Head Posture
Status: RECRUITING
Conditions: Forward Head Posture
Interventions: OTHER: Specific strengthening and stretching exercise|OTHER: General Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Novel Gene Therapy ZM-01 for X-linked Retinoschisis Patients
Status: RECRUITING
Conditions: X-linked Retinoschisis
Interventions: DRUG: ZM-01-L|DRUG: ZM-01-H
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of Rituximab on Immune Responses in Subjects With Active Rheumatoid Arthritis Receiving Background Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Rituximab|DRUG: Methotrexate|DRUG: Methylprednisone|BIOLOGICAL: C. albicans|BIOLOGICAL: Tetanus toxoid adsorbed booster vaccine|BIOLOGICAL: 23-valent pneumococcal polysaccharide vaccine|BIOLOGICAL: Keyhole limpet hemocyanin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venous Function in Cardiovascular Disease Patients
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: BEHAVIORAL: interval training day 1|BEHAVIORAL: Moderate exercise day 2|BEHAVIORAL: Control day 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multi Modal Stimulations in Pre-term Neonates
Status: COMPLETED
Conditions: Preterm Birth|Infant, Premature, Diseases
Interventions: OTHER: Sensory Stimulation|OTHER: Movement therapy|OTHER: Routine hospital care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety of Drug Eluting Stents in the "Real World" (FReIburger STent Registry)
Status: UNKNOWN
Conditions: Stent Thrombosis
Interventions: PROCEDURE: transluminal percutaneous coronary intervention|DEVICE: Drug-Eluting and Bare-Metal stents
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: DANish Study of Optimal Acute Treatment of Patients With ST-elevation Myocardial Infarction
Status: ACTIVE_NOT_RECRUITING
Conditions: ST Segment Elevation Myocardial Infarction
Interventions: OTHER: Conventional primary PCI|OTHER: Ischemic postconditioning.|OTHER: Deferred stenting in primary PCI.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Atezolizumab (Anti-Programmed Death-Ligand 1 [PD-L1] Antibody) Alone or in Combination With an Immunomodulatory Drug and/or Daratumumab in Participants With Multiple Myeloma (MM)
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Atezolizumab (MPDL3280A), an engineered anti-PD-L1 antibody|DRUG: Daratumumab|DRUG: Lenalidomide|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bacterial Sexually Transmitted Infections (STIs) Viability by Polymerase Chain Reaction (PCR)
Status: RECRUITING
Conditions: Men Who Have Sex With Men
Interventions: PROCEDURE: Collection of throat swab|PROCEDURE: Collection of anal swab|PROCEDURE: Collection of first void urine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Silymarin in COVID-19 Pneumonia
Status: UNKNOWN
Conditions: COVID-19|Viral Pneumonia Human Coronavirus
Interventions: DRUG: Silymarin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Pharmacokinetic and Pharmacodynamic Profiles for Sitagliptin, Saxagliptin and Vildagliptin in Participants With Type 2 Diabetes Mellitus (T2DM) (MK-0431-142)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin 100 mg|DRUG: Saxagliptin 5 mg|DRUG: Vildagliptin 50 mg|DRUG: Vildagliptin 50 mg BID|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Study to Assess the Anti-proliferative Activity of the PARP Inhibitor Olaparib in Patients With HPV Positive and HPV Negative HNSCC
Status: WITHDRAWN
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: POF Versus FOLFOX Versus FOLFOX Plus ip Paclitaxel in AGC
Status: COMPLETED
Conditions: Malignant Neoplasm of Stomach Stage IV
Interventions: DRUG: POF|DRUG: FOLFOX|DRUG: FOLFOX plus PAC(ip)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Follow-up Automatically vs. As-Needed Comparison (FAAN-C) Trial
Status: RECRUITING
Conditions: Pneumonia|Urinary Tract Infections|Soft Tissue Infections|Gastroenteritis
Interventions: BEHAVIORAL: As-needed follow up|BEHAVIORAL: Automatic follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Telbivudine or Tenofovir Treatment in HBeAg-negative Chronic Hepatitis B Patients Based on the Roadmap Concept
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: telbivudine|DRUG: tenofovir disoproxil fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Number of Patients With Gastro-Oesophageal Reflux Disease (GORD) Achieving Heartburn and Regurgitation Symptom Resolution After Treatment With Either Rabeprazole Sodium 20mg, Esomeprazole 20mg or Esomeprazole 40mg
Status: COMPLETED
Conditions: Gastro-oesophageal Reflux
Interventions: DRUG: Esomeprazole|DRUG: Rabeprazole|DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Using Advanced Driver Assistance Systems (ADAS) as an Intervention Strategy for Drivers With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Driving Impaired
Interventions: DEVICE: Lane change assistance system|BEHAVIORAL: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Pharmacokinetic and Mass Balance Study of Orally Administered [14C]-AZD4205 in Healthy Adult Male Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: [14C]-AZD4205, single 50 mg oral dose administrated on day 1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Renal Denervation in Hypertrophic Cardiomyopathy
Status: RECRUITING
Conditions: Hypertrophic Cardiomyopathy
Interventions: DEVICE: "Symplicity Spyral" multi-electrode renal denervation catheter and "Symplicity G3" generator (Renal Denervation System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lifestyle, Exercise and Diet: The LEAD Study
Status: TERMINATED
Conditions: Subjective Cognitive Decline|Age-Related Cognitive Decline
Interventions: BEHAVIORAL: Exercise plus nutrition|BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of a Wearable Device-based Assisted Post-stroke Rehabilitation System
Status: COMPLETED
Conditions: Post-Acute-Stroke Rehabilitation
Interventions: DEVICE: Customized exercise app|OTHER: In-person therapist-supervised rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Potential for Cytochrome P450 3A4 Inhibition by F901318 Using Oral Midazolam as a Probe
Status: COMPLETED
Conditions: Invasive Aspergillosis
Interventions: DRUG: Midazolam with F901318
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KTP (Potassium-titanyl-phosphate) Laser Versus TUR-P (Transurethral Resection of Prostate)
Status: COMPLETED
Conditions: BPH (Benign Prostatic Hyperplasia)
Interventions: DEVICE: Green light Laser|DEVICE: Transurethral Resection of the Prostate (TURP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exoskeleton Research: Myoelectric Orthosis for Rehab of Severe Chronic Arm Motor Deficits
Status: RECRUITING
Conditions: Chronic Stroke
Interventions: BEHAVIORAL: motor learning based therapy|BEHAVIORAL: MyoPro|BEHAVIORAL: Home Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Supportive Program for Mother With BPD
Status: COMPLETED
Conditions: Parent-child Problem|Borderline Personality Disorder
Interventions: OTHER: Supportive Program for Mother with BPD (SuPMother-B).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intermittent Hypoxic-hyperoxic Training in Patients With Cardiovascular Pathology After COVID-19 Infection.
Status: RECRUITING
Conditions: COVID-19|Chronic Heart Failure|Hypertension|Arrhythmia|Conduct Disorder|Chronic Coronary Syndrome|Endothelial Dysfunction|Diastolic Dysfunction|Oxygen Consumption|Quality of Life|Exercise Tolerance
Interventions: PROCEDURE: Intermittent hypoxic-hyperoxic training|PROCEDURE: Intermittent hypoxic-hyperoxic training/control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized Control Trial of Narrative Exposure Therapy Versus Treatment as Usual in the Therapy of Borderline Personality Disorder
Status: UNKNOWN
Conditions: Posttraumatic Stress Disorders|Borderline Personality Disorders
Interventions: BEHAVIORAL: narrative exposure therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MetMAb Administered to Patients With Advanced Non-Small Cell Lung Cancer, in Combination With Tarceva (Erlotinib)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Erlotinib HCl|DRUG: MetMAb|DRUG: placebo (0.9 % saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Abdominal Binder to Treat Orthostatic Hypotension (OH) in Parkinson's Disease (PD)
Status: COMPLETED
Conditions: Parkinson's Disease|Neurogenic Orthostatic Hypotension in Parkinson's Disease
Interventions: DEVICE: Elastic abdominal binder|DEVICE: Placebo binder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT