pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: BOOST - Benefit of Frequent Optimization After Cardiac Resynchronization Therapy Device Replacement
Status: TERMINATED
Conditions: Heart Failure
Interventions: DEVICE: QuickOpt - SJM CRT (Group 1)|DEVICE: Control - SJM CRT (Group 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clofarabine and Ara-C for the Treatment of Relapsed AML and Untreated MDS
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Myelodysplastic Syndromes|Chronic Myelogenous Leukemia
Interventions: DRUG: Clofarabine and Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety of Menactra® Vaccine When Administered With Other Pediatric Vaccines to Healthy Toddlers
Status: COMPLETED
Conditions: Meningococcal Meningitis|Measles|Mumps|Rubella|Varicella
Interventions: BIOLOGICAL: Menactra®: Meningococcal Polysaccharide Diphtheria Toxoid Conjugate|BIOLOGICAL: Measles-mumps-rubella-varicella vaccine|BIOLOGICAL: Routine paediatric vaccine - Pneumococcal conjugate (PCV)|BIOLOGICAL: Routine paediatric vaccine - Hepatitis A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Definitive Therapy to Treat Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Leuprolide Acetate|DRUG: Bicalutamide|DRUG: Docetaxel|PROCEDURE: Prostatectomy|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation Of The Efficacy And Safety Of Single Doses Of PF-05089771 In Patients With Primary (Inherited) Erythromelalgia
Status: COMPLETED
Conditions: Inherited Erythromelalgia
Interventions: DRUG: PF-05089771|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Consolidation Therapy With Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19 in Patients With Chronic Lymphocytic Leukemia Following Upfront Chemotherapy With Pentostatin, Cyclophosphamide and Rituximab
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: cyclophosphamide|BIOLOGICAL: modified T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Technology Enhanced Home Exercise Program and Other Non-pharmacological Intervention for Cancer Survivors
Status: RECRUITING
Conditions: Cancer-related Problem/Condition|Exercise|Acupressure
Interventions: BEHAVIORAL: Technology Enhanced Home Exercise (TEHE)|BEHAVIORAL: Auricular Point Acupressure (APA)|BEHAVIORAL: Mindfulness body scan (MBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arthroscopic Autologous Chondrocyte Implantation Versus Microfractures
Status: COMPLETED
Conditions: Tear; Knee, Cartilage, Articular
Interventions: PROCEDURE: Matrix encapsulated chondrocyte implantation|PROCEDURE: Microfracture awl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass (CPB) in Cardiac Surgery
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: nitroglycerin|DRUG: esmolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Efficacy of Intranasal Oxytocin Among Individuals With Persistent Pain
Status: COMPLETED
Conditions: Chronic Pain|Pelvic Pain
Interventions: DRUG: Intranasal Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Single-Dose Oral Ranolazine in Hemodialysis Patients
Status: COMPLETED
Conditions: End-stage Renal Disease|Cardiovascular Disease
Interventions: DRUG: Ranolazine|PROCEDURE: Pharmacokinetic Blood and Dialysate Sampling|PROCEDURE: QT Interval
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rescue Intracranial Stenting in Acute Ischemic Stroke
Status: COMPLETED
Conditions: Acute Stroke|Ischemic Stroke|Intracranial Atherosclerosis|Stent Stenosis|Cerebral Ischemia|Stent Occlusion|Stroke, Ischemic|Intracranial Hemorrhages|Thrombotic Stroke, Acute
Interventions: PROCEDURE: Rescue intracranial stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spironolactone Against Anthracycline-induced Cardiomyopathy
Status: COMPLETED
Conditions: Anthracycline Induced Cardiotoxicity
Interventions: DRUG: Spironolactone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Take it Personal!
Status: RECRUITING
Conditions: Alcohol Use|Drug Use|Mild Intellectual Disability, IQ 50-70|Borderline Intellectual Disabilities (Intelligence Quotient 70-85)|Personality|Adolescent Behavior
Interventions: BEHAVIORAL: Take it Personal!
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Choline to Improve Malnutrition and Enhance Cognition
Status: RECRUITING
Conditions: Severe Acute Malnutrition|Cognitive Impairment|Wasting|Kwashiorkor
Interventions: DIETARY_SUPPLEMENT: C-RUTF (Ready-to-Use Therapeutic Food with added choline)|DIETARY_SUPPLEMENT: S-RUTF (Ready-to-Use Therapeutic Food without added choline)|DRUG: Amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of XYWAV on Sleepiness, Polysomnography, and Functional Outcomes in Participants With Idiopathic Hypersomnia or Narcolepsy
Status: RECRUITING
Conditions: Idiopathic Hypersomnia|Narcolepsy
Interventions: DRUG: JZP258 (XYWAV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Phentermine Pharmacotherapy: An Investigation for Symptoms of Dependence, Cravings, or Withdrawal
Status: COMPLETED
Conditions: Obesity|Phentermine Withdrawal
Interventions: DRUG: Abrupt cessation of phentermine pharmacotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heartache and Backache- An Online Intervention Addressing Emotional and Physical Pain
Status: RECRUITING
Conditions: Chronic Pain (Back / Neck)
Interventions: BEHAVIORAL: Pain Psychology Neuroscience + Written Emotional Disclosure|BEHAVIORAL: Pain Psychology Neuroscience + Healthy Habits Disclosure|BEHAVIORAL: Health Behavior Control + Written Emotional Disclosure|BEHAVIORAL: Health Behavior Control + Healthy Habits Disclosure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Smart Nitinol Stent System for the Treatment of Severe Atherosclerotic Carotid Stenosis
Status: COMPLETED
Conditions: Carotid Artery Stenosis
Interventions: DEVICE: Smart nitinol stent implantation|DRUG: antiplatelet drug
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Kinesio Taping on Kyphosis and Quality of Life in Adolescents
Status: ENROLLING_BY_INVITATION
Conditions: Kyphosis|Kyphosis Thoracic|Kyphosis Postural Thoracic
Interventions: PROCEDURE: physical therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Development and Initial Tests of Reward Re-Training: A Novel Treatment For Reward Dysfunction
Status: COMPLETED
Conditions: Binge Eating|Binge-Eating Disorder|Bulimia Nervosa
Interventions: BEHAVIORAL: Group Reward Retraining
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Chronic Rhinosinusitis in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis|Sinusitis
Interventions: OTHER: Assessment of upper and lower airway colonization, sinonasal symptoms, history, rhinoscopy and rhinomanometry.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Low-Level Laser Therapy and Orthotic Insole in Tibialis Posterior Tendon Insufficiency
Status: COMPLETED
Conditions: Posterior Tibial Tendon Insufficiency
Interventions: DEVICE: Orthotic Insole|DEVICE: Low-Level Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Phase 1 Study of Liralutide Injection in Healthy Chinese Subjects
Status: COMPLETED
Conditions: Therapeutic Equivalency
Interventions: DRUG: Liraglutide injection|DRUG: Liraglutide injection(Victoza®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Ropivacaine Versus Bupivacaine as Preemptive Analgesia in Surgical Site in Ankle Fracture Patients
Status: COMPLETED
Conditions: Ankle Fractures|Pain, Postoperative|Local Infiltration
Interventions: DRUG: Ropivacaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: RICE: Radio-Immuno-Chemotherapy of Cancer of the Esophagus
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Adenocarcinoma
Interventions: DRUG: Durvalumab 50 MG/ML|DRUG: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemtuzumab Ozogamicin in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Undergoing Remission Induction and Intensification Therapy
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: asparaginase|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: etoposide|DRUG: gemtuzumab ozogamicin|DRUG: methotrexate|DRUG: mitoxantrone hydrochloride|PROCEDURE: allogeneic bone marrow transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Daclatasvir (BMS-790052) Plus Pegylated Interferon-Alfa 2a and Ribavirin in Patients Coinfected With Untreated Hepatitis C Virus and HIV Virus
Status: COMPLETED
Conditions: Hepatitis C, Genotype 1
Interventions: DRUG: Daclatasvir|DRUG: Ribavirin|DRUG: PEG-Interferon alfa 2a
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Participant Study of an Experimental ASO Treatment for TUBB4A-related Leukodystrophy
Status: NOT_YET_RECRUITING
Conditions: Genetic Disease
Interventions: DRUG: Antisense oligonucleotide treatment (ASO)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anatomy Based Selection of CI Array for SSD Patients
Status: NOT_YET_RECRUITING
Conditions: Single-Sided Deafness
Interventions: OTHER: Anatomy-Based Electrode Array Selection|OTHER: Standard of Care Electrode Array Selection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Stage I, Stage II, or Stage IIIA Non-small Cell Lung Cancer or With Stage I or Stage II Mesothelioma
Status: COMPLETED
Conditions: Lung Cancer|Malignant Mesothelioma
Interventions: BIOLOGICAL: lung tumor associated antigen|DRUG: DetoxPC|DRUG: chemotherapy|DRUG: cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Infants With Spinal Muscular Atrophy
Status: TERMINATED
Conditions: Spinal Muscular Atrophy
Interventions: DRUG: nusinersen|PROCEDURE: Sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Imaging of the Whole Body, Including Diffusion, in the Medical Evaluation of Breast Cancers at High Risk for Metastasis and the Follow-up of Metastatic Cancers
Status: UNKNOWN
Conditions: Metastatic Breastcancer
Interventions: DEVICE: whole body MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Kilimanjaro IPTi Drug Options Trial
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: sulphadoxine-pyrimethamine|DRUG: mefloquine|DRUG: Chlorproguanil-dapsone|DRUG: Placebo|DRUG: Sulphadoxine-pryrimethamine|DRUG: IPTi mefloquine|DRUG: Chlorproguanil dapsone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: New Bone Grafting Technique in Paediatric Foot Surgery. Validation of Outcome Measures
Status: TERMINATED
Conditions: Pes Planovalgus
Interventions: DEVICE: ReproBone|PROCEDURE: calcaneal lengthening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemorrhoids and Metalloproteinases, Observational Study
Status: COMPLETED
Conditions: HEMORRHOIDS|Extracellular Matrix Alteration
Interventions: PROCEDURE: Hemorrhoidectomy|OTHER: blood sampling|OTHER: tissue sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lipid-lowering Therapies in Vietnamese Chronic Kidney Disease Population
Status: UNKNOWN
Conditions: Hypercholesterolemia|Chronic Kidney Diseases
Interventions: DRUG: Simvastatin 40mg|DRUG: Ezetimibe/simvastatin 10/20 mg/day|DRUG: Ezetimibe/simvastatin 10/40 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Closed Kinetic Chain Lower Extremity Stability Test (CKCLEST): A New Clinical Performance Test
Status: COMPLETED
Conditions: Healthy
Interventions: PROCEDURE: Some clinical evaluation performance tests together with procedure of Closed Kinetic Chain Lower Extremity Stability Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Pharmacokinetic Study to Access How the Body Absorbs and Removes ABT-199 in Adults With Non-Hodgkin's Lymphoma
Status: WITHDRAWN
Conditions: Relapsed/Refractory Non-Hodgkin's Lymphoma
Interventions: DRUG: [14C]ABT-199 (GDC-0199)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Randomized, Open-Label, Comparative 3-Way Treatment Crossover Study of 24-Hour Intragastric pH Profile of Once Daily Oral Administration of Esomeprazole 40mg, Lansoprazole 30mg, and Pantoprazole 40mg at Steady State in NSAID-Using Patients
Status: COMPLETED
Conditions: Heartburn|Upper Abdominal Pain|Nausea|Acid Regurgitation
Interventions: DRUG: Esomeprazole|DRUG: Lansoprazole|DRUG: Pantoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Respiratory Muscle Structure and Function in Mechanically Ventilated Patients and Long-term Outcomes
Status: RECRUITING
Conditions: Mechanical Ventilation Complication|Diaphragm Injury|Lung Injury|Respiratory Insufficiency|Abdominal Muscle Strained
Interventions: OTHER: Sonographic measurements|OTHER: Physiological measurements|OTHER: Biological measurements
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Imatinib Mesylate With or Without Interferon Alfa or Cytarabine Compared With Interferon Alfa Followed by Donor Stem Cell Transplant in Treating Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: recombinant interferon alfa|DRUG: cytarabine|DRUG: hydroxyurea|DRUG: imatinib mesylate|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lorcaserin and Behavioral Modification for Overweight and Obesity Management in Chinese Obese Patients
Status: TERMINATED
Conditions: Obesity
Interventions: DRUG: Lorcaserin 10 mg BID|DRUG: Matching Placebo BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vorinostat in Patients With Primary Cutaneous T-Cell Lymphoma
Status: TERMINATED
Conditions: Cutaneous T-cell Lymphoma Stage I|Cutaneous T-cell Lymphoma Stage II|Cutaneous T-cell Lymphoma Stage III|Cutaneous T-cell Lymphoma Stage IV
Interventions: DRUG: vorinostat|OTHER: flow cytometry|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Co-administration of Ezetimibe Plus Simvastatin Versus Simvastatin Alone in Primary Hypercholesterolemia (P03476)
Status: COMPLETED
Conditions: Atherosclerosis|Hypercholesterolemia|Coronary Heart Disease
Interventions: DRUG: Ezetimibe|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaginal lIve Biotherapeutic RANdomized Trial
Status: RECRUITING
Conditions: Bacterial Vaginosis
Interventions: DRUG: LC106|DRUG: LC115|DRUG: Placebo|DRUG: Metronidazole Oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Lucentis on Psychological Morbidity in Patients With Retinal Vein Occlusion
Status: UNKNOWN
Conditions: Venous Retinal Branch Occlusion|Central Retinal Vein Occlusion|Retinal Vein Occlusion|Depression
Interventions: DRUG: ranibizumab (Lucentis)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temozolomide and O6-benzylguanine in Treating Patients With Newly Diagnosed, Recurrent, or Progressive Anaplastic Glioma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: O6-benzylguanine|DRUG: temozolomide|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study to Compare Sol-Gel Technologies' 5-FU Cream With Efudex® (5-FU) Cream
Status: COMPLETED
Conditions: Actinic Keratosis (AK)
Interventions: DRUG: 5-FU Cream|DRUG: Efudex®|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multidisciplinary Approach for Treat To Target In Rheumatoid Arthritis
Status: NOT_YET_RECRUITING
Conditions: Arthritis, Rheumatoid
Interventions: BEHAVIORAL: Rheumatoid arthritis educational booklet|BEHAVIORAL: Multidisciplinary rheumatologic care|BEHAVIORAL: Nurse education and monthly calls|BEHAVIORAL: Monthly healthcare coordinator calls|BEHAVIORAL: Technology-based symptom monitoring and reporting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of Ramipril 10 mg Capsules of Dr. Reddy's Laboratories Limited, Under Non-Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ramipril|DRUG: Altace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiparametric Quantitative MRI and Response to Neoadjuvant Radiotherapy for Soft-tissue Sarcoma
Status: RECRUITING
Conditions: Soft Tissue Sarcoma|Adult Soft Tissue Sarcoma|Resectable Soft Tissue Sarcoma
Interventions: RADIATION: Neoadjuvant RT|OTHER: Pre-radiotherapy mpMRI|OTHER: Post-radiotherapy mpMRI|PROCEDURE: Tumor resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of io Fibrewater Supplementation on Gut Health, Immunity and Metabolism in Overweight Adults
Status: RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Enriched fibre water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Utility of Intensified Case Finding Combined With a Package of Novel TB Diagnostics Using a Mobile Clinic in Africa
Status: COMPLETED
Conditions: Tuberculosis
Interventions: PROCEDURE: GeneXpert MTB/RIF assay|PROCEDURE: Smear microscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rapid Onset Action of Salbutamol Versus Formoterol
Status: UNKNOWN
Conditions: Bronchial Asthma
Interventions: DRUG: salbutamol|DRUG: Formoterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Vaccination Take-Up
Status: COMPLETED
Conditions: Covid19|Vaccination
Interventions: BEHAVIORAL: Financial incentives|BEHAVIORAL: Convenient scheduling link|BEHAVIORAL: Race concordant|BEHAVIORAL: Gender concordant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Low Molecular Weight Heparin and Aspirin in the Treatment of Recurrent Pregnancy Loss: A RCT
Status: TERMINATED
Conditions: Recurrent Pregnancy Loss|Antiphospholipid Antibody Syndrome
Interventions: DRUG: Low molecular weight heparin and low dose aspirin|DRUG: Low dose aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Subcutaneous Semaglutide on Kidney Transplant Candidacy
Status: TERMINATED
Conditions: CKD|Diabetic Kidney Disease|Type 2 Diabetes Mellitus in Obese|Obesity|Severe Obesity
Interventions: DRUG: Semaglutide 2 mg/1.5 ml (1.34 mg/ml), prefilled pen-injector for subcutaneous injection solution|DRUG: Placebo 1.5 ml, prefilled pen-injector for subcutaneous injection solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Establishing the Vitamin D Requirements During Lactation
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DRUG: 400 IU Vitamin D3 (cholecalciferol)|DRUG: 2400 IU Vitamin D3 (cholecalciferol)|DRUG: 6400 IU Vitamin D3 (cholecalciferol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The POWERED Study: Prophylaxis With Metformin to Prevent PTDM
Status: COMPLETED
Conditions: Post-transplant Diabetes Mellitus|New Onset Diabetes After Transplant|New Onset Diabetes After Transplantation|Kidney Transplant; Complications|Renal Transplantation|End Stage Renal Disease|Metformin
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ultrasound-guided Intermediate Cervical Plexus Block
Status: COMPLETED
Conditions: Internal Carotid Artery Stenosis
Interventions: OTHER: cervical plexus block|OTHER: facial nerve block|OTHER: perivascular block
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultraviolet-C Effectiveness in the Management of Pressure Ulcers in People With Spinal Cord Injury
Status: COMPLETED
Conditions: Pressure Ulcer
Interventions: DEVICE: ultraviolet therapy UV254|DEVICE: Placebo ultraviolet therapy UV254
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapy of Fifth Metacarpal Neck Fractures - Comparing Functional Treatment With Reposition and Finger Splinting
Status: NOT_YET_RECRUITING
Conditions: Boxer's Fracture
Interventions: PROCEDURE: Functional Treatment|PROCEDURE: Forearm Cast and Finger Splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Pregabalin and COX2 in Spinal Stenosis
Status: UNKNOWN
Conditions: Spinal Stenosis Lumbar
Interventions: DRUG: Pregabalin 75mg|DRUG: Celebrex 200Mg Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HRV and Coaching Preparation Phase Study
Status: COMPLETED
Conditions: Health Behavior|Work Related Stress|Job Stress|Anxiety Depression
Interventions: BEHAVIORAL: Core Health Program|BEHAVIORAL: Daily resting HRV|BEHAVIORAL: Momentary HRV feedback|BEHAVIORAL: Behavioural initiation coaching|BEHAVIORAL: Practice with feedback coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dose-effect Relationship of Rt-PA on ICH Evacuation
Status: UNKNOWN
Conditions: Hypertensive Intracerebral Hemorrhage
Interventions: DEVICE: YL-1 type of intracranial hematoma puncture needle|DRUG: rt-PA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sentinel lympH Node Biopsy With Indocyanine Green in Breast Cancer After NEoadjuvant Chemotherapy (SHINE)
Status: RECRUITING
Conditions: Breast Cancer
Interventions: PROCEDURE: ICG guided sentinel lymph node biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-TNFα Use During Elective Foot and Ankle Surgery in Patients With Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Anti-TNF suspended perioperatively|DRUG: Anti-TNFα continued perioperatively
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Prenatal Nutritional Supplementation on Birth Outcome in Hounde District, Burkina Faso
Status: COMPLETED
Conditions: Intrauterine Growth Retardation|Low Birth Weight
Interventions: DIETARY_SUPPLEMENT: UNIMMAP - multiple micronutrients|DIETARY_SUPPLEMENT: Food supplement enriched with multiple micronutrients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Preventing Early Childhood Caries With Silver Diamine Fluoride
Status: RECRUITING
Conditions: Dental Caries
Interventions: DEVICE: silver diamine fluoride|DEVICE: sodium fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Survival on Peritoneal Dialysis (PD) Versus Hemodialysis (HD) in China
Status: TERMINATED
Conditions: End Stage Renal Disease
Interventions: OTHER: Peritoneal Dialysis treatment|OTHER: Hemodialysis treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Bilirubinometry in Healthy Term and Near-Term Neonates
Status: COMPLETED
Conditions: Hyperbilirubinemia
Interventions: DEVICE: BiliChek (jaundice assessment)|PROCEDURE: Transcutaneous bilirubinometry (TcB)|OTHER: Clinical asessment of bilirubin (CaB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Gallium-68 PSMA-11 PET in Patients With Biochemical Recurrence
Status: COMPLETED
Conditions: Prostate Cancer|Prostate Adenocarcinoma|Prostate Cancer Metastatic|Prostate Cancer Recurrent
Interventions: DRUG: 68Ga-PSMA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Investigate the Effect of Food, Gender, and Age on the Pharmacokinetic Profile of SUVN-D4010 in Healthy Subjects
Status: COMPLETED
Conditions: Cognitive Disorder
Interventions: DRUG: SUVN-D4010
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Danoprevir/Ritonavir on the Pharmacokinetics of Escitalopram and S-Demethylcitalopram in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: danoprevir|DRUG: escitalopram|DRUG: ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Direct Cortical Measurement of the Intensity and Pattern of Current Flow Produced by TDCS
Status: ACTIVE_NOT_RECRUITING
Conditions: Epilepsy
Interventions: DEVICE: Transcranial Direct Current Stimulation (TDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Importance of Integrated Pulmonary Index in Pediatric Endoscopy
Status: COMPLETED
Conditions: Monitored Anesthesia Care|Respiratory Monitoring
Interventions: DEVICE: Integrated Pulmonary Index (IPI) monitoring|DRUG: propofol|DRUG: ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Assess the Efficacy and Safety of Subcutaneous AGX-201 for Migraine Prophylaxis
Status: UNKNOWN
Conditions: Migraine Prophylaxis
Interventions: DRUG: AGX-201|DRUG: Subcutaneous placebo (Evan's solution = phenol 0.4%, isotonic sodium chloride).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Jing Si Herbal Tea Liquid Packets on Fatigue in Patients With Inflammatory Arthritis
Status: ENROLLING_BY_INVITATION
Conditions: Arthritis|Rheumatoid Arthritis|Ankylosing Spondylitis|Psoriatic Arthritis|Fatigue
Interventions: DIETARY_SUPPLEMENT: Jing Si Herbal Tea LIQUID PACKETS|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Statins for Chinese Patients With Dyslipidemia
Status: UNKNOWN
Conditions: Dyslipidemias
Interventions: DRUG: Pitavastatin|DRUG: Atorvastatin|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protocol for a Research Sample Repository for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries
Status: RECRUITING
Conditions: Autologous Stem Cell Transplantation|Allogeneic Stem Cell Transplantation|Cellular Therapy|Marrow Toxic Injury
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas
Status: RECRUITING
Conditions: Relapsed Sarcomas
Interventions: DRUG: Disulfiram|DRUG: Copper Gluconate|DRUG: Liposomal Doxorubicin (Doxil)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AccuCath Guidewire Intravenous (IV) Device Versus Conventional IV Catheter In General Nursing Use
Status: COMPLETED
Conditions: Vascular Access Complication
Interventions: DEVICE: AccuCath IV Catheter Device|DEVICE: Conventional IV Catheter Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SHARE Study 4: Financial Incentives for Weight Loss
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Online weight loss + incentives for behavior 3 months|BEHAVIORAL: Online weight loss + incentives for weight loss at month 3|BEHAVIORAL: Online weight loss + Incentives for behavior 12 months|BEHAVIORAL: Online weight loss + Incentives for weight loss 12 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Everolimus and Pemetrexed in Lung Cancer Patients
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Everolimus|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel, Carboplatin, and Bevacizumab or Paclitaxel, Carboplatin, and Temsirolimus or Ixabepilone, Carboplatin, and Bevacizumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Adenocarcinoma|Endometrial Adenosquamous Carcinoma|Endometrial Clear Cell Adenocarcinoma|Endometrial Serous Adenocarcinoma|Recurrent Uterine Corpus Cancer|Stage IIIA Uterine Corpus Cancer AJCC v7|Stage IIIB Uterine Corpus Cancer AJCC v7|Stage IIIC Uterine Corpus Cancer AJCC v7|Stage IVA Uterine Corpus Cancer AJCC v7|Stage IVB Uterine Corpus Cancer AJCC v7
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Carboplatin|DRUG: Ixabepilone|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nasal Decongestion and Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndrome|Rhinitis
Interventions: DRUG: xylometazoline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label, Long-term Study of Telmisartan Plus Amlodipine Fixed-dose Combination
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: telmisartan40/amlodipine5|DRUG: telmisartan80/amlodipine5
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Hypersensitivity to Opening of BKCa Channels in Post-Traumatic Headache
Status: UNKNOWN
Conditions: Post-Traumatic Headache
Interventions: DRUG: Maxipost|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Virtual Weight Control Program Tailored for Adults With Type 2 Diabetes (VITAL)
Status: COMPLETED
Conditions: Type2 Diabetes|Overweight and Obesity
Interventions: BEHAVIORAL: WW program modified for people with Type 2 diabetes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Rehabilitation Training Based on Brain-computer Interface Technology to Improve the Upper Limb Motor Function of Ischemic Stroke.
Status: COMPLETED
Conditions: Hemiplegia Following Ischemic Stroke
Interventions: DEVICE: Brain-computer interface|OTHER: Traditional rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study Evaluating Dimebon in Patients With Mild to Moderate Alzheimer's Disease on Donepezil
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Dimebon|DRUG: Dimebon|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Testing the Effect and Safety of Casopitant (GW679769) While Taking Warfarin in Healthy Human Volunteers
Status: COMPLETED
Conditions: Nausea and Vomiting, Chemotherapy-Induced
Interventions: DRUG: Casopitant (GW679769) oral tablets|DRUG: Warfarin oral tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Transcranial Direct Current Stimulation (tDCS).
Status: TERMINATED
Conditions: Ankle Sprains|Musculoskeletal Injury
Interventions: OTHER: Transcranial Direct Current Stimulation|OTHER: Sham Transcranial Direct Current Stimulation|OTHER: Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Artificial Intelligence Versus Expert Endoscopists for Diagnosis of Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DIAGNOSTIC_TEST: AI-based diagnosis|DIAGNOSTIC_TEST: The expert endoscopists-based diagnosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2)
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome|Lung Diseases|Cardiovascular Diseases|Heart Diseases|Heart Failure|HIV Infections|Cytomegalovirus Infections|Pneumocystis Carinii Infections|Ebstein-Barr Virus Infections
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Platelet Rich Plasma Testis Treatment for Infertile Men
Status: RECRUITING
Conditions: Male Infertility|Nonobstructive Azoospermia|Azoospermia
Interventions: BIOLOGICAL: Platelet rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rasburicase in Preventing Graft-Versus-Host Disease in Patients With Hematologic Cancer or Other Disease Undergoing Donor Stem Cell Transplant
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: DRUG: busulfan|DRUG: cyclophosphamide|DRUG: cyclosporin-A|DRUG: etoposide|DRUG: methotrexate|DRUG: rasburicase|DRUG: sirolimus|DRUG: tacrolimus|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: total-body irradiation|DRUG: fludarabine|DRUG: allopurinol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Preoperative Cognitive Behavioural Therapy Program Based on Self-determination Theory for Bariatric Surgery Candidates
Status: COMPLETED
Conditions: Bariatric Surgery Candidate|Obesity
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oblimersen, Thalidomide, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: oblimersen sodium|DRUG: dexamethasone|DRUG: thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MK-7145 in Participants With Renal Insufficiency (Part I) and Heart Failure With Renal Insufficiency (Part II) (MK-7145-011)
Status: TERMINATED
Conditions: Renal Impairment|Heart Failure
Interventions: DRUG: MK-7145|DRUG: Furosemide|DRUG: Torsemide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correlation Between PaCO2 and Respiratory Effort in Patients With COVID-19 With Extracorporeal Membrane Oxygenation
Status: COMPLETED
Conditions: COVID-19 Acute Respiratory Distress Syndrome|Extracorporeal Membrane Oxygenation Complication|Respiratory Effort-Related Arousal
Interventions: DEVICE: PaCO2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ventilator-associated Pneumonia (VAP) and Humidification System
Status: UNKNOWN
Conditions: Ventilator-associated Pneumonia
Interventions: DEVICE: HME filter Twin Star 55, Drager Medical, Germany|DEVICE: Heated humidification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: STELLA Trial: Transperitoneal vs. Extraperitoneal Approach for Laparoscopic Staging of Endometrial/Ovarian Cancer
Status: COMPLETED
Conditions: Endometrial Neoplasms|Ovarian Neoplasms
Interventions: PROCEDURE: Transperitoneal laparoscopic aortic lymphadenectomy|PROCEDURE: Extraperitoneal laparoscopic aortic lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: An Online Large-group One-session Training to Enhance Positive Mental Health
Status: COMPLETED
Conditions: Psychology, Positive|Psychological Distress
Interventions: BEHAVIORAL: Online large-group one-session multicomponent positive psychological intervention|BEHAVIORAL: Online large-group one-session cognitive intervention targeting dysfunctional thoughts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: L. Reuteri ATCC PTA 5289 & L. Reuteri DSM 17938 for the Treatment of Children With Pharyngitis and/or Tonsillitis
Status: COMPLETED
Conditions: Pharyngitis|Tonsillitis
Interventions: DIETARY_SUPPLEMENT: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Efficacy of Parecoxib in Patients With Subarachnoid Hemorrhage
Status: NOT_YET_RECRUITING
Conditions: Neurological Complication
Interventions: DRUG: Parecoxib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Gaze Stability Exercises on Balance and Activities of Daily Living Among Patients Suffering Vertigo With Vestibular Neuritis in Saudi Arabia
Status: UNKNOWN
Conditions: Vertigo|Vertigo, Peripheral|Vertigo Labyrinthine|Migraine
Interventions: OTHER: Gaze stability exercises and balance exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigational Scan (7T MRI) for the Imaging of Central Nervous System Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Central Nervous System Neoplasm|Glioma|Metastatic Malignant Neoplasm in the Central Nervous System|Metastatic Malignant Solid Neoplasm
Interventions: PROCEDURE: 7 Tesla Magnetic Resonance Imaging|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Local Participatory Systems Dynamics to Increase Reach of Evidence Based Addiction and Mental Health Care
Status: UNKNOWN
Conditions: PTSD|Depression|Alcohol Use Disorder|Opioid Use Disorder
Interventions: OTHER: Participatory System Dynamics (PSD)|OTHER: Audit and Feedback (AF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Activated Recombinant Human Factor VII Following Cardiac Bypass Surgery for Paediatric Congenital Heart Disease
Status: COMPLETED
Conditions: Acquired Bleeding Disorder|Cardiac Surgery Requiring Cardiopulmonary Bypass
Interventions: DRUG: activated recombinant human factor VII|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Accelerated Vaccination Schedule Against Hepatitis B Virus With Combined Hepatitis A and B Vaccine Among Hemodialysis Patients
Status: COMPLETED
Conditions: Hepatitis B|Hemodialysis Complication
Interventions: DRUG: Hepatitis B recombinant DNA vaccine|DRUG: Combined hepatitis A and B vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: FEED-Cystic Fibrosis (FEED-CF)
Status: RECRUITING
Conditions: Cystic Fibrosis|Cystic Fibrosis-related Diabetes
Interventions: OTHER: Low-added sugar, high-fat diet|OTHER: High-added sugar, high-fat CF diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION