pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Bortezomib and Rituximab in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Lymphoma
Interventions: DRUG: bortezomib|DRUG: rituximab|PROCEDURE: antibody therapy|PROCEDURE: biological therapy|PROCEDURE: enzyme inhibitor therapy|PROCEDURE: monoclonal antibody therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plastic Stents vs. NAGI Bi-flanged Metal Stent for Endoscopic Ultrasound Guided Drainage of Walled-off Necrosis
Status: UNKNOWN
Conditions: Acute Necrotizing Pancreatitis|Walled Off Necrosis
Interventions: DEVICE: Endosonography guided transmural drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of AMPS on Cardiovascular Variables in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DEVICE: Automated mechanical peripheral stimulation|OTHER: Physical Exercise|DEVICE: SHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of AC-150 for the Treatment of Allergic Conjunctivitis in the Enviro-CAC™ Model
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: AC-150 Combo|DRUG: AC-150A 0.1%|DRUG: AC-150B 0.005%|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase IIa Study of Subcutaneous AER 001 on Antigen Challenge In Atopic Asthmatic Subjects (28 Day Study)
Status: COMPLETED
Conditions: Allergic Asthma
Interventions: DRUG: AER 001|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double Blind Trial of Bromfenac BID (0.09%) as an Adjunct to Argon Laser Therapy in the Treatment of Diabetic Macular Edema.
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Bromefenac|DRUG: Blink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Lung Ultrasound Scores With Clinical Models for Predicting Bronchopulmonary Dysplasia：A Multi-center Prospective Cohort Study
Status: NOT_YET_RECRUITING
Conditions: Lung Ultrasound|Bronchopulmonary Dysplasia
Interventions: DIAGNOSTIC_TEST: lung ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 1, Open-label, Safety and Immunogenicity Study of an Oral Multi-dose Administration Regimen With an Adenoviral-vector Based Tablet Norovirus Vaccine (VXA-G1.1-NN) Administered to Healthy Adult Volunteers
Status: COMPLETED
Conditions: Norovirus Infections
Interventions: BIOLOGICAL: VXA-G1.1-NN
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: RESOLUTE International Registry: Evaluation of the Resolute Zotarolimus-Eluting Stent System in a 'Real-World' Patient Population
Status: COMPLETED
Conditions: Coronary Artery Disease|Cardiovascular Diseases
Interventions: DEVICE: Endeavor Resolute Zotarolimus-Eluting Coronary Stent System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics and Pharmacodynamics of Dexmedetomidine in Pediatrics Subjects
Status: COMPLETED
Conditions: Intubated and Mechanically Ventilated Pediatric Subjects
Interventions: DRUG: Dexmedetomidine, midazolam; fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fascial Manipulation® Associated With Standard Care Versus Standard Post-surgical Care for Total Hip Arthroplasty
Status: COMPLETED
Conditions: Arthritis
Interventions: OTHER: Fascial Manipulation® (FM)|OTHER: standard active exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lacosamide Effects on Alcohol Self Administration and Craving in Heavy Drinkers
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: DRUG: Lacosamide|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Onartuzumab (MetMAb) in Combination With Bevacizumab Compared to Bevacizumab Alone or Onartuzumab Monotherapy in Participants With Recurrent Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: Bevacizumab|DRUG: Onartuzumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ketamine Versus Etomidate for Rapid Sequence Intubation
Status: COMPLETED
Conditions: Airway Control|Anesthesia|Intubation|Complication
Interventions: DRUG: Ketamine|DRUG: Etomidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Pharmacodynamics and Pharmacokinetics of OPC-41061 in Patients With Hepatic Edema
Status: COMPLETED
Conditions: Cirrhosis
Interventions: DRUG: OPC-41061|DRUG: OPC-41061
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Pulsed Electromagnetic Field Therapy on Patients With End-stage of Knee Osteoarthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Osteoarthritis|Sarcopenia
Interventions: OTHER: home-based-exercise|DEVICE: active pulsed electromagnetic field（PEMF）therapy|DEVICE: shame pulsed electromagnetic field（PEMF）therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tenecteplase for Acute Ischemic Stroke Within 4.5 to 6 Hours of Onset (EXIT-BT2)
Status: RECRUITING
Conditions: Stroke, Ischemic
Interventions: DRUG: Tenecteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start Study
Status: COMPLETED
Conditions: Copd|Smoking Cessation|Nicotine Dependence|Tobacco Use|Cigarette Smoking
Interventions: BEHAVIORAL: Unified Protocol adapted for smoking cessation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Deep Inspiration Breath Hold (DIBH)-Expiration Planning Technique in Patients With Lung Tumors in Close Proximity to the Chest Wall
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer|Metastatic Cancer
Interventions: RADIATION: Treatment Planning using the DIBH Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Insulin Degludec Formulations in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec|DRUG: insulin degludec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Auricular Vagus Stimulation in Obesity
Status: ACTIVE_NOT_RECRUITING
Conditions: Vagus Nerve Stimulation|Obesity
Interventions: DEVICE: Active TENS|DEVICE: Sham TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improvement of Patient Satisfaction and Clinical Outcomes Using JointCOACH
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Hip|Arthroplasty, Replacement, Knee
Interventions: OTHER: JointCOACH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Clinical Performance, Safety and Pharmacology Effect of EscharEx in Patients With Lower Leg Ulcers
Status: COMPLETED
Conditions: Venous Leg Ulcer|Diabetic Foot Ulcer
Interventions: DRUG: EscharEx (EX-02 formulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peri-Transfusion QOL Assessments (PTQA): A New Paradigm of Transfusion Decision Support for Patients With MDS
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: OTHER: Peri-Transfusion QOL Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Parenteral Nutrition With Intravenous and Oral Fish Oil for Intensive Care Patients
Status: COMPLETED
Conditions: Critical Illness
Interventions: DRUG: Nutriflex Omega special + Oxepa|DRUG: Nutriflex Lipid special + Pulmocare
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remote Glucose Monitoring System in Hospitalized Patients With Diabetic Ketoacidosis (DKA)
Status: UNKNOWN
Conditions: Diabetic Ketoacidosis
Interventions: DEVICE: DEXCOM G6 CGM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Sleep Improvement Intervention for Hospitalized Antepartum Patients
Status: COMPLETED
Conditions: Sleep Disturbance in Hospitalized Antepartum Patients
Interventions: BEHAVIORAL: Sleep Improvement Protocol Intervention for Hospitalized Antepartum Patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incidence of Invasive Pulmonary Aspergillosis in Ventilator-associated Pneumonia
Status: NOT_YET_RECRUITING
Conditions: Ventilator Associated Pneumonia|Pulmonary Aspergillosis Invasive
Interventions: OTHER: Biological examinations performed on blood and BAL
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Therapy Light Rooms for Improved Sleep in Dementia Patients
Status: COMPLETED
Conditions: Sleep Fragmentation|Behavioural and Psychiatric Symptoms of Dementia|Dementia
Interventions: OTHER: Therapy light room|OTHER: Standard light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Core Stabilization Exercise Therapy in Chronic Lower Back Back Management in Community Dwelling Older Adults
Status: RECRUITING
Conditions: Chronic Low-back Pain|Older Adults|Core Stabilization Exercise Therapy
Interventions: BEHAVIORAL: core stabilization exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Three-dimensional Assessment of the Bone Changes Accompanying Laser-assisted Orthodontic Tooth Movement
Status: COMPLETED
Conditions: Low Level Laser Therapy|Canine Retraction|Orthodontic Tooth Movement
Interventions: RADIATION: Low level laser therapy|OTHER: without beam emission
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Brazilian Reality of Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Hepatocellular Carcinoma by BCLC Stage|Hepatocellular Carcinoma Stage I|Hepatocellular Carcinoma Stage II|Hepatocellular Carcinoma Stage III
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase II Study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2-positive Metastatic Solid Tumors and Metastases to Brain (TUCATEMEB)
Status: RECRUITING
Conditions: Metastatic Solid Tumor|Brain Metastases
Interventions: DRUG: Trastuzumab emtansine|DRUG: Tucatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Massage and Reflexology Applications in Children With Cerebral Palsy
Status: UNKNOWN
Conditions: Cerebral Palsy|Chronic Constipation
Interventions: OTHER: Reflexology|OTHER: Connective Tissue Massage|OTHER: Classic abdominal massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Whole-body Exercise to Improve Swallowing Function in Older Adults With Dementia
Status: COMPLETED
Conditions: Old Age; Dementia|Swallowing Disorder|Cough|Parkinson Disease|Neuro-Degenerative Disease
Interventions: BEHAVIORAL: Whole-body exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Add-on Low Dose Dextromethorphan and Memantine in Patients With Amphetamine-type Stimulants Use Disorder
Status: COMPLETED
Conditions: Stimulants Use Disorder
Interventions: DRUG: dextromethorphan and memantine (DM+MM)|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Addition of Curcumin for 10 Days Triple Therapy, on the Eradication Rate of Helicobacter Pylori Infection
Status: UNKNOWN
Conditions: Positivity for Helicobacter Pylori
Interventions: DIETARY_SUPPLEMENT: Curcumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Logotherapy in Adolescents With Mood Disorders
Status: NOT_YET_RECRUITING
Conditions: Mood Disorder of Depressed Type
Interventions: OTHER: logotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combined Amiodarone and Electrical Cardioversion for Postoperative Atrial Fibrillation After Cardiac Surgery
Status: TERMINATED
Conditions: Cardiac Disease
Interventions: DRUG: Amiodarone|PROCEDURE: Cardioversion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endocuff Vision Colonoscopy vs. AmplifEYE Colonoscopy
Status: COMPLETED
Conditions: Colorectal Adenoma|Colorectal Polyp|Colorectal Cancer
Interventions: DEVICE: Endocuff Vision device|DEVICE: AmplifEYE device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: An Open-label Study of Poly-l-lactic Acid for Correction of Wrinkles in the décolletage Area
Status: COMPLETED
Conditions: Wrinkles in Decolletage
Interventions: DEVICE: poly-l-lactic acid (Sculptra)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fixed-duration Therapy With Ibrutinib and Obinutuzumab (GA-101) in Treatment-naïve Patients With CLL
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Ibrutinib and obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of PDE4 Inhibition With Roflumilast (ARQ-154) Foam 0.3% for the Management of Seborrheic Dermatitis (STRATUM)
Status: COMPLETED
Conditions: Seborrheic Dermatitis
Interventions: DRUG: Roflumilast Foam|DRUG: Vehicle Foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Iron Sucrose in Arthroplasty
Status: UNKNOWN
Conditions: Osteoarthritis
Interventions: DRUG: Iron Sucrose 200mg|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thermal Imaging in Neonates: A Feasibility Study in Healthy Babies and Babies With Suspected TTN
Status: COMPLETED
Conditions: Thermal Imaging, Neonatal Pneumonia, Tachypnea
Interventions: DEVICE: Thermal Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: First-In-Human Trial of the MiStent Drug-Eluting Stent (DES) in Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: MiStent SES
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Efficacy and Safety of Adjunctive Topiramate in the Treatment of Obsessive-Compulsive Disorder
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: Topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Treatment Free Remission in Patients With Chronic Myeloid Leukemia in Chronic Phase
Status: RECRUITING
Conditions: CML
Interventions: DRUG: Discontinuing treatment with Tyrosine Kinase Inhibitor after enrolment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genotypic Versus Phenotypic Susceptibility Testing of Positive Blood Cultures
Status: UNKNOWN
Conditions: Bloodstream Infection
Interventions: DIAGNOSTIC_TEST: Accelerate PhenoTest™ BC kit|DIAGNOSTIC_TEST: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I Dose Escalation Study of Topotecan and Pazopanib in Children With Recurrent/Refractory Solid Tumours
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Topotecan and Pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Adding Lamotrigine to Sodium Valproate in Childhood Epilepsy: Clinicolabratory Study
Status: NOT_YET_RECRUITING
Conditions: Epilepsy|Lamotrigine|Sodium Valproate Adverse Reaction
Interventions: DRUG: Sodium Valproate 500 Mg Prolonged-Release Oral Tablet|DRUG: Lamotrigine|DEVICE: E.E.G
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Melatonin Upon Post-Acute Withdrawal Among Males in a Residential Treatment Program
Status: COMPLETED
Conditions: Substance Withdrawal Syndrome
Interventions: DIETARY_SUPPLEMENT: Melatonin|DIETARY_SUPPLEMENT: Matched Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Once Daily and Twice Daily Dosing on Safety and Tolerability of Memantine in Patients With Alzheimer
Status: COMPLETED
Conditions: Alzheimer Dementia (AD)
Interventions: DRUG: Memantine (once daily)|DRUG: Memantine (twice daily)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Epi-keratoplasty Versus Collagen Cross-Linking in Progressive Keratoconus
Status: UNKNOWN
Conditions: Progressive Keratoconus
Interventions: PROCEDURE: Epi-keratoplasty|PROCEDURE: Collagen Cross-Linking|DEVICE: Femtosecond laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Transvenous Vagus Nerve Stimulation on Immune Response: a Pilot Study
Status: COMPLETED
Conditions: Inflammation
Interventions: DEVICE: Vagal Nerve Stimulation|DEVICE: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Kefir and Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome|Cardiovascular Diseases|Hypertension
Interventions: DIETARY_SUPPLEMENT: probiotic milk fermented with kefir grains|DIETARY_SUPPLEMENT: curd
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Pentoxifylline on PAI-1 in an Obese Population
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Pentoxifylline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: COmbined N-acetylcysteine and Bicarbonate in PCI To Reduce Adverse Side Effect of contrasT
Status: COMPLETED
Conditions: Contrast Induced Nephropathy
Interventions: DRUG: N-acetylcysteine|DRUG: Sodium Bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Ustekinumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis (UC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Colitis, Ulcerative
Interventions: DRUG: Ustekinumab Dose Based on BSA and Body Weight|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in Children Previously Immunized With JE-CV
Status: COMPLETED
Conditions: Japanese Encephalitis|Varicella
Interventions: BIOLOGICAL: JE-CV Vaccine|BIOLOGICAL: Varicella Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Single Ascending Doses Study With GNbAC1 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: GNbAC1|OTHER: GNbAC1 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development, Feasibility and Acceptability of Fathers and Babies (FAB): A Pilot Study
Status: COMPLETED
Conditions: Perinatal Depression|Postpartum Depression|Depression
Interventions: BEHAVIORAL: Fathers and Babies (FAB)|BEHAVIORAL: MB 1-on-1 plus TXT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety Study of a Topical Treatment for Dry Age Related Macular Degeneration
Status: COMPLETED
Conditions: Nonexudative Age-related Macular Degeneration
Interventions: DRUG: MC-1101, Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Proof of Concept Trial Investigating Safety and Efficacy of APG-157 in Oral Dysplasia
Status: RECRUITING
Conditions: Oropharyngeal Dysplasia|Oral Cavity Dysplasia|Oral Carcinoma in Situ
Interventions: DRUG: APG-157
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrauterine Use of FloSeal: Is it Safe and Useful?
Status: COMPLETED
Conditions: Operative Hemorrhage
Interventions: PROCEDURE: Hysterectomy with FloSeal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Immunogenicity and Compatibility With DTP of a Typhoid Fever Vaccine in Infants
Status: COMPLETED
Conditions: Typhoid Fever
Interventions: BIOLOGICAL: Vi-rEPA conjugate vaccine for typhoid fever|BIOLOGICAL: Hib-TT|BIOLOGICAL: DTP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Post-release Retention in HIV Care for Ex-inmates in South Africa
Status: COMPLETED
Conditions: Hiv|Adherence, Patient
Interventions: BEHAVIORAL: Transition Community Adherence Club (TCAC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Transcutaneous Photobiomodulation on the Control of Chilhood Anxiety in Dental Care.
Status: UNKNOWN
Conditions: Anxiety
Interventions: DEVICE: Photobiomodulation|DEVICE: Photobiomodulation sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of High Testosterone on Sleep-associated Slowing of Follicular Luteinizing Hormone (LH) Frequency in Polycystic Ovary Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Flutamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Visual Acuity After the Combined Binocular Implantation of +2.0 Diopters and +3.0 Diopters Oculentis Multifocal Intraocular Lenses.
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Binocular cataract surgery with phacoemulsification and implantation of multifocal intraocular lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Systemic Microvascular Endothelial Function in Metabolically Healthy Obesity
Status: COMPLETED
Conditions: Obesity|Dyslipidemias
Interventions: DIAGNOSTIC_TEST: Evaluation of systemic skin microvascular endothelial function
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Ofatumumab Dose-finding in Relapsing Remitting Multiple Sclerosis (RRMS) Patients
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Ofatumumab 100|DRUG: Ofatumumab 300|DRUG: Ofatumumab 700|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study, Double Blind, Randomized, Comparing Two Groups to Evaluate the Safety and Efficacy of Autologous Mesenchymal Stem Cells From Adipose Tissue (CMMAd) in the Treatment of the Faecal Incontinence
Status: COMPLETED
Conditions: Faecal Incontinence
Interventions: DRUG: Infusion of mesenchymal stem cells from adipose tissue|OTHER: Infusion of placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Abciximab and Reteplase When Administered Prior to Catherization After a Myocardial Infarction (Finesse)
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: abciximab placebo; reteplase placebo, abciximab, abciximab|DRUG: Abciximab; reteplase; abciximab placebo; abciximab|DRUG: abciximab; reteplase placebo; abciximab placebo; abciximab|DRUG: abciximab placebo; reteplase placebo, abciximab, abciximab|DRUG: abciximab; reteplase placebo; abciximab placebo; abciximab|DRUG: Abciximab; reteplase; abciximab placebo; abciximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Treatment of Periodontal Diseases
Status: UNKNOWN
Conditions: Digestive System Disorders|Adverse Effects
Interventions: DRUG: Metronidazol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Open and Laparoscopic Splenic Aneurysms Repair
Status: COMPLETED
Conditions: Splenic Artery Aneurysm
Interventions: PROCEDURE: Laparoscopic splenic aneurysm repair, eventual splenectomy|PROCEDURE: Laparotomic splenic artery aneurysm repair, eventual artery reconstruction or splenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: XmAb®20717 (Vudalimab) Alone or in Combination With Chemotherapy or Targeted Therapy in Patients With Metastatic Castration-Resistant Prostate Cancer
Status: RECRUITING
Conditions: Metastatic Castration-Resistant Prostate Cancer
Interventions: COMBINATION_PRODUCT: vudalimab + carboplatin + cabazitaxel|COMBINATION_PRODUCT: vudalimab + olaparib|BIOLOGICAL: vudalimab monotherapy|COMBINATION_PRODUCT: vudalimab + docetaxel|COMBINATION_PRODUCT: vudalimab + cabazitaxel or docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Undiagnosed Lysosomal Acid Lipase Deficiency
Status: UNKNOWN
Conditions: Lysosomal Acid Lipase Deficiency|Cholesterol Ester Storage Disease
Interventions: OTHER: enzyme analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Haemofiltration Study : IVOIRE (hIgh VOlume in Intensive Care)
Status: COMPLETED
Conditions: Shock, Septic|Renal Failure, Acute
Interventions: DEVICE: Venovenous haemofiltration (renal replacement therapy)|DEVICE: Venovenous haemofiltration (renal replacement therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of SNF472 on Progression of Cardiovascular Calcification in End-Stage-Renal-Disease (ESRD) Patients on Hemodialysis (HD)
Status: COMPLETED
Conditions: Cardiovascular Diseases|Cardiovascular Abnormalities|Calcifications, Vascular|Endstage Renal Disease|ESRD|Coronary Artery Calcification
Interventions: DRUG: SNF472|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Up-Down Determination of the ED90 of Phenylephrine for Hypotension Prophylaxis in Cesarean Delivery
Status: TERMINATED
Conditions: Spinal Induced Hypotension in Cesarean Delivery
Interventions: DRUG: Phenylephrine infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial of Tolcapone in Obsessive Compulsive Disorder
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder|OCD
Interventions: DRUG: Tolcapone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antenatal Vitamin D3 Supplementation in Bangladesh: Randomized Controlled Trial
Status: COMPLETED
Conditions: Pregnancy
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Examine the Safety and Effectiveness of Implanted Skeletal Muscle Cells (Cells Removed From the Thigh Muscle) Into Scarred Areas of Heart Muscle After Heart Attack.
Status: TERMINATED
Conditions: Ischemic Heart Failure|Ischemic Heart Disease|Ischemic Cardiomyopathy
Interventions: DRUG: Cellular Therapy (Cultured Autologous Skeletal Myoblast Transplantation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of Procedure Started in the Morning and Afternoon on Early Postoperative Sleep Function and Postoperative Recovery in Patients Under General Anesthesia
Status: COMPLETED
Conditions: Postoperative Complications
Interventions: OTHER: morning surgery|OTHER: afternoon surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Geriatric Transitional Care for Older Patients Discharged From the Emergency Department: Impact on Early Readmissions
Status: NOT_YET_RECRUITING
Conditions: Hospital Readmissions of Elderly Patients
Interventions: OTHER: Transitional Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Study of a Fluid Accommodating Intraocular Lens (IOL) Design
Status: RECRUITING
Conditions: Cataract
Interventions: DEVICE: BAL-FAIOL IOL|DEVICE: Monofocal IOL|PROCEDURE: Cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Human Amniotic Epithelial Cells Prevent Acute Graft-versus-host Disease After Hematopoietic Stem Cell Transplantation
Status: UNKNOWN
Conditions: Acute-graft-versus-host Disease
Interventions: BIOLOGICAL: hAECs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A2-ESO-1 TCR-Engineered T Cells for Relapsed/Refractory Advanced or Metastatic NY-ESO-1 Overexpression Positive Triple Negative Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: BIOLOGICAL: Aldesleukin|BIOLOGICAL: Anti-HLA-A2/NY-ESO-1 TCR-transduced Autologous T Lymphocytes|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Cyclophosphamide|PROCEDURE: Echocardiography|DRUG: Fludarabine|PROCEDURE: Leukapheresis|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Mammogram|PROCEDURE: Multigated Acquisition Scan|PROCEDURE: Ultrasound Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-Driven Lifestyle Modification Using FreeStyle Libre in Type 2 Diabetes Patients
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Lifestyle Risk Reduction
Interventions: DEVICE: FreeStyle Libre|DEVICE: Blood glucose meter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-time Monitoring of Motor Cortical Activity Induced by Low-frequency Repetitive Transcranial Magnetic Stimulation
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: low frequency rTMS + Navigation System|DEVICE: only low frequency rTMS|DEVICE: Sham low frequency rTMS + Navigation System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Alemtuzumab and Clofarabine for Relapsed or Refractory Acute Lymphoblastic Leukemia
Status: TERMINATED
Conditions: Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: Alemtuzumab|DRUG: Clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals
Status: RECRUITING
Conditions: Diabetes Mellitus|Cardiovascular Diseases|Insulin Sensitivity/Resistance|Metabolic Disease|Natriuretic Peptides|Metabolism|Energy Expenditure
Interventions: DRUG: Sacubitril, Valsartan 97-103 mg Oral Tablet|DRUG: Valsartan 160 mg|OTHER: Intravenous Glucose Tolerance Test|DIETARY_SUPPLEMENT: Standardized Meals|OTHER: Exercise capacity VO2 maximum determination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of MK-6194 for the Treatment of Vitiligo (MK-6194-007)
Status: RECRUITING
Conditions: Non-segmental Vitiligo
Interventions: BIOLOGICAL: MK-6194|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)
Status: UNKNOWN
Conditions: Aortic Valve Stenosis
Interventions: OTHER: Echocardiography|OTHER: Computed tomography|OTHER: Magnetic resonance imaging|OTHER: Blood biomarkers|OTHER: Stress echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MCLENA-2: A Phase II Clinical Trial for the Assessment of Lenalidomide in Patients With Mild Cognitive Impairment Due to Alzheimer's Disease
Status: NOT_YET_RECRUITING
Conditions: Cognitive Impairment, Mild|Cognitive Dysfunction|Amyloid Plaque|Neurodegenerative Disease, Hereditary|Inflammation, Brain
Interventions: DRUG: Lenalidomide 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 and 2 Study of PX-866 and Cetuximab
Status: COMPLETED
Conditions: Incurable Metastatic Colorectal Carcinoma|Incurable Progressive, Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: PX-866 (SCCHN)|DRUG: Cetuximab (SCCHN)|DRUG: PX-866 (CRC)|DRUG: Cetuximab (CRC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrical Brain Stimulation for Treatment of Secondary Symptoms in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DEVICE: transcranial direct current stimulation|DEVICE: transcranial direct current stimulation combined with cognitive training|DEVICE: transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of PillCam™ Colon 2 in Visualization of the Colon
Status: COMPLETED
Conditions: Colonic Diseases|Bowel Diseases
Interventions: DEVICE: PillCam™ (Capsule Endoscopy) Colon 2 capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Partners in Dementia Care: A Telephone Care Consultation Intervention Provided to Veterans in Partnership With Local Alzheimer's Association Chapters
Status: COMPLETED
Conditions: Dementia|Alzheimer Disease
Interventions: BEHAVIORAL: Partners in Dementia Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EC50 of Dexmedetomidine in Deep Brain Stimulation Implantation of Patients With Parkinson's Disease
Status: UNKNOWN
Conditions: PD - Parkinson's Disease
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Working Memory Training in Adults With Substance Abuse and Executive Function Deficits.
Status: UNKNOWN
Conditions: Substance Abuse|Executive Dysfunction|Anxiety|Depression|Antisocial Personality|Reading Disabilities
Interventions: BEHAVIORAL: Computerized Cogmed working memory training|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Troponin I Surveillance Among Patients Undergoing Acute High-risk Abdominal Surgery
Status: COMPLETED
Conditions: Abdomen, Acute|Myocardial Injury After Non-cardiac Surgery|Troponin I|Myocardial Injury|Emergency Surgery
Interventions: DIAGNOSTIC_TEST: Troponin I
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: COmputerized CTG Self-MOnitoring Versus Standard Doppler Assessment in Late-onset FGR: COSMOS Study
Status: RECRUITING
Conditions: Fetal Growth Restriction
Interventions: DEVICE: cCTG|DIAGNOSTIC_TEST: Doppler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Minimizing Facial Nerve Stimulation in Cochlear Implants
Status: UNKNOWN
Conditions: Cochlear Hearing Loss|Hearing Loss, Sensorineural|Hearing Loss|Facial Nerve Injury|Nerve Disorders
Interventions: PROCEDURE: Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Saccharomyces Boulardii on Indirect Hyperbilirubinemia and Phototherapy Duration in Very Low Birth Weight Infants
Status: UNKNOWN
Conditions: Indirect Hyperbilirubinemia
Interventions: DIETARY_SUPPLEMENT: Reflor|OTHER: serum physiologic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: NM-IL-12 (rHuIL-12) in Subjects With Open Surgical Wounds
Status: COMPLETED
Conditions: Colostomy Stoma
Interventions: BIOLOGICAL: NM-IL-12|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Food Study of Escitalopram Oxalate Tablets 20 mg to Lexapro® Tablets 20 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Escitalopram Oxalate Tablets 20 mg|DRUG: Lexapro® Tablets 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Evaluate Imetelstat (GRN163L) in Subjects With International Prognostic Scoring System (IPSS) Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Imetelstat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Perfusion Index Variability in Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Poor Peripheral Perfusion
Interventions: DRUG: Beractant|DRUG: Poractant alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Metastatic Melanoma of the Eye That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Intraocular Melanoma
Interventions: DRUG: nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Evaluating Study to Compare Kanarb (Fimasartan) and Cozaar® (Losartan) in Adult Patients With Grade I-II Arterial Hypertension
Status: COMPLETED
Conditions: Arterial Hypertension
Interventions: DRUG: Fimasartan|DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Travoprost Ophthalmic Topical Cream for Open-angle Glaucoma or Ocular Hypertension
Status: RECRUITING
Conditions: Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Travoprost Ophthalmic Topical Cream low-dose|DRUG: Travoprost Ophthalmic Topical Cream mid-dose|DRUG: Travoprost Ophthalmic Topical Cream high-dose|DRUG: Timolol maleate ophthalmic solution, 0.5%|DRUG: Travoprost Ophthalmic Solution, 0.004%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Potential Role of SI00B and Brain Derived Neurotrophic Factor in Predicting Outcome From Using Pulsed Radiofrequency in Treatment of Patients With Lumbar Disc Prolapsed
Status: UNKNOWN
Conditions: Investigation the Role of BDNF and S100B Serum Level as a Predictive of Outcome of Pulsed Radiofrequency in Treatment Lumbar Disc Prolapse Patients
Interventions: PROCEDURE: Pulsed mood radiofrequency on dorsal root ganglion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Excess Opioid Disposal Following Orthopedic Foot and Ankle Surgery
Status: COMPLETED
Conditions: Medication Disposal|Behavior
Interventions: DEVICE: Deterra Drug Deactivation System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Low Cost Socket for Lower Limb Amputees
Status: RECRUITING
Conditions: Amputation|Amputation; Traumatic, Limb|Amputation, Traumatic
Interventions: DEVICE: Low cost lower limb prosthetic socket
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Utilizing Gaming Mechanics to Optimize Telerehabilitation Adherence in Persons With Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: BEHAVIORAL: Home Telerehabilitation using HoVRS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial on Treatment of Steroid-refractory Bronchiolitis Obliterans With Interferon Gamma 1b After Allogeneic SCT
Status: UNKNOWN
Conditions: Steroid-refractory Bronchiolitis Obliterans
Interventions: DRUG: Interferon gamma 1b
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT