pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Intranasal Midazolam for Treatment of Anxiety in Children Undergoing Suturing in the Pediatric Emergency Department
Status: COMPLETED
Conditions: Anxiety|Lacerations
Interventions: DRUG: Midazolam|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of BMS-986036 in Subjects With Non-Alcoholic Steatohepatitis (NASH)
Status: COMPLETED
Conditions: Non-Alcoholic Steatohepatitis
Interventions: DRUG: BMS-986036|DRUG: BMS-986036|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Mesenchymal Stem Cells for Radiation-induced Hyposalivation and Xerostomia/Dry Mouth
Status: ACTIVE_NOT_RECRUITING
Conditions: Xerostomia Due to Radiotherapy|Hyposalivation|Xerostomia|Oropharynx Cancer|Salivary Gland Diseases|Dry Mouth|Mesenchymal Stem Cells|Mesenchymal Stromal Cells|Stem Cells
Interventions: BIOLOGICAL: Allogeneic adipose derived stem/stromal cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancement of Calmness and Mood Following Acute Lemon Balm Supplementation During Cognitive Demand in Adults
Status: COMPLETED
Conditions: Stress|Mood Disturbance
Interventions: DIETARY_SUPPLEMENT: Lemon balm|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases
Status: RECRUITING
Conditions: Metabolic Disorders|Hematologic, Immune, or Bone Marrow Disorders|Hemoglobinopathies|Non-malignant Disorders
Interventions: DRUG: Treatment Plan 1: Stratum 1|DRUG: Treatment Plan 2: Strata 2, 3, or 4|DRUG: GVHD Regimen A: UCB Recipients|DRUG: GVHD Regimen B: BM Recipients
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: INfrapatellar Versus SUprapatellar Reamed Intramedullary Nailing for Fractures of the Tibia
Status: COMPLETED
Conditions: Tibial Fractures|Anterior Knee Pain Syndrome
Interventions: PROCEDURE: Infrapatellar Approach|PROCEDURE: Suprapatellar Approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Operative vs Non-operative Management of Posterior-medial Meniscal Root Tears: A Randomized Multicenter Trial (RCT)
Status: RECRUITING
Conditions: Meniscus Tear, Tibial
Interventions: OTHER: Non-Operative Pain Management|PROCEDURE: Operative treatment arm will undergo transtibial medial meniscus root repair within 3 weeks of enrollment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Pulmonary Rehabilitation in COPD: Effects of Two Aerobic Exercise Intensity in Patient-centered Outcomes
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Aerobic exercise training intensity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Local Estriol Treatment Before Vaginal Repair Surgery
Status: NOT_YET_RECRUITING
Conditions: Pelvic Organ Prolapse|Pelvic Floor Disorders|Menopause|Vaginal Atrophy
Interventions: DRUG: estriol cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Recurrent Ulcer Bleeding in Patients With Idiopathic Gastroduodenal Ulcer
Status: RECRUITING
Conditions: Active Peptic Ulcer Disease/GI Bleeding
Interventions: DRUG: Misoprostol Oral Tablet|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Periodontal Therapy on Markers of Acute Phase Response, Oxidative Stress
Status: COMPLETED
Conditions: Periodontitis
Interventions: PROCEDURE: Scaling and Root Planing (S&RP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PGL4001 Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata
Status: COMPLETED
Conditions: Uterine Fibroids
Interventions: DRUG: Ulipristal Acetate - open label
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ONC201 in Treating Patients With Relapsed or Refractory Acute Leukemia or High-Risk Myelodysplastic Syndrome
Status: RECRUITING
Conditions: Recurrent Acute Lymphoblastic Leukemia|Recurrent Acute Myeloid Leukemia|Recurrent Myelodysplastic Syndrome|Refractory Acute Lymphoblastic Leukemia|Refractory Acute Myeloid Leukemia|Refractory Myelodysplastic Syndrome
Interventions: DRUG: Akt/ERK Inhibitor ONC201
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Calcineurin & mTOR Inhibitors in HIV-1 Infected Kidney Transplant Recipients After Switch to BIC/FTC/TAF
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV-infected Patient Kidney Transplant Recipient
Interventions: DRUG: Biktarvy Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shortness Of Breath Questionnaire Validation Study
Status: WITHDRAWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: fluticasone propionate/salmeterol 250/50mcg combination, salmeterol 50mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Kamishibai Diabetes Education on Knowledge, HbA1c, and Quality of Life in Children
Status: NOT_YET_RECRUITING
Conditions: DIABETES EDUCATION
Interventions: OTHER: kamishibai education|OTHER: routine education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of AutoloGel Therapy to Usual and Customary Care in Wagner gd 1 and 2 Diabetic Foot Ulcers.
Status: TERMINATED
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: AutoloGel|OTHER: Usual and Customary Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Soluble Corn Fiber on BMD in Pre-pubertal Boys and Girls (PREBONE-Kids)
Status: COMPLETED
Conditions: Bone Health
Interventions: DIETARY_SUPPLEMENT: Usual intake + placebo fruit juice|DIETARY_SUPPLEMENT: Usual intake+SCF fruit juice|DIETARY_SUPPLEMENT: Adequate calcium + placebo fruit juice|DIETARY_SUPPLEMENT: Adequate calcium+ SCF fruit juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Immersive Virtual Reality Reminiscence Versus Traditional Reminiscence Therapy on Cognitive Function and Psychological Wellbeing Among Institutionalized Older Adults: A Randomized Controlled Trial
Status: RECRUITING
Conditions: Institutionalized Older Adults
Interventions: BEHAVIORAL: Immersive Virtual Reality Reminiscence|BEHAVIORAL: Traditional Reminiscence Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Erythromycin Versus Gastric Lavage to Improve Quality of Endoscopy in Patients With Upper Gastrointestinal Bleeding
Status: UNKNOWN
Conditions: Gastrointestinal Hemorrhage|Hematemesis
Interventions: DRUG: Erythromycin|PROCEDURE: gastric lavage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Minocycline as an Adjunct for the Treatment of Depressive Symptoms: Pilot Randomized Controlled Trial
Status: COMPLETED
Conditions: Depressive Disorder|Mood Disorders|Depressive Disorder, Treatment Resistant|Antidepressive Agents
Interventions: DRUG: Minocycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Three Surgical Approaches to Zygomaticomaxillary Fractures
Status: COMPLETED
Conditions: Zygomatic Fractures
Interventions: PROCEDURE: subtarsal approach|PROCEDURE: conventional transconjunctival approach|PROCEDURE: transconjunctival approach with Y- modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Misoprostol With Mechanical Dilation Versus Oxytocin With Mechanical Dilation for High-risk Pregnancy Inductions
Status: COMPLETED
Conditions: Cesarean Section|Misoprostol|Oxytocin|High Risk Pregnancy
Interventions: DRUG: Oxytocin|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 6-month Observational Study on Combined Oral Contraceptives and Body Weight in Pre-Menopausal Women With Overweight or Obesity
Status: ACTIVE_NOT_RECRUITING
Conditions: Contraceptive Usage|Overweight or Obesity|Body Weight Changes|Appetitive Behavior|Eating Behavior
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Insulin Glargine (Lantus) vs Sulfonylurea (SU) for BETA Cell Function (BETA Study)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Insulin glargine|DRUG: Glimepiride|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension Study to Gather Data on Effect of Macugen on the Corneal Endothelium
Status: COMPLETED
Conditions: Age-Related Macular Degeneration|Retinal Vein Occlusion|Diabetic Macular Edema
Interventions: DRUG: pegaptanib sodium injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of SIMEOX on Static Hyperinflation in Patients With COPD
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DEVICE: SIMEOX|DEVICE: PEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short-term Renal Hemodynamic Effects of Tolvaptan in Subjects With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Status: COMPLETED
Conditions: Autosomal Dominant Polycystic Kidney Disease
Interventions: DRUG: Tolvaptan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study to See if Kidney Damage in People With Chronic Kidney Disease and Type 2 Diabetes Living With Overweight or Obesity Can be Reduced by CagriSema Compared to Semaglutide, Cagrilintide and Placebo
Status: RECRUITING
Conditions: Chronic Kidney Disease|Type 2 Diabetes|Obesity
Interventions: DRUG: Cagrilintide|DRUG: Semaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remotely-supervised Transcranial Direct Current Stimulation (tDCS) for At-home Treatment of Fatigue and Cognitive Slowing in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DEVICE: Active tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Temporomandibular Dysfunction With Hypertonic Dextrose Injection
Status: COMPLETED
Conditions: Temporomandibular Joint Disorders
Interventions: OTHER: Injection of 20% dextrose/ 0.2% lidocaine|OTHER: Injection of 1 ml of 0.8 Sterile water /0.2% lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of Single Rising Oral Doses of BI 113823 Powder in Bottle (PiB) and Tablet in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 113823 solution|DRUG: BI 113823 tablet|DRUG: Placebo|OTHER: High fat, high calorie breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Pralsetinib Versus Standard of Care for First-Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC)
Status: ACTIVE_NOT_RECRUITING
Conditions: RET-fusion Non Small Cell Lung Cancer|Lung Neoplasm|Carcinoma, Non-Small-Cell Lung|Respiratory Tract Neoplasms|Thoracic Neoplasms|Neoplasms by Site|Neoplasms|Lung Diseases|Respiratory Tract Disease|Carcinoma, Bronchogenic|Bronchial Diseases|Head and Neck Neoplasms|Adenocarcinoma|Carcinoma|Neoplasms by Histologic Type|Neoplasms, Germ Cell and Embryonal|Neoplasms, Nerve Tissue
Interventions: DRUG: Pralsetinib|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Pemetrexed|DRUG: Pembrolizumab|DRUG: Gemcitabine|DRUG: Paclitaxel|DRUG: Nab-Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Autonomic Nervous System During First-dosing With 0.5mg of Fingolimod (Gilenya) in Patients With Relapsing-remitting MS
Status: COMPLETED
Conditions: Multiple Sclerosis|Autonomic Nervous System Dysfunction
Interventions: DRUG: Gilenya
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Prebiotics Versus Low FODMAPs Diet on Intestinal Microbiota and Symptoms
Status: COMPLETED
Conditions: Functional Gastrointestinal Disorders
Interventions: DIETARY_SUPPLEMENT: Bimuno Galacto-oligosaccharide 1.37 g/d|DIETARY_SUPPLEMENT: Low- FODMAPs diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sodium Nitroprusside in Early Course Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Sodium Nitroprusside|DRUG: 5% Dextrose solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel With Bevacizumab as First-Line Therapy in Treating Women With Stage IV Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)
Status: RECRUITING
Conditions: Non-rhabdomyosarcoma|Adipocytic Neoplasm|Liposarcoma
Interventions: PROCEDURE: Surgical resection|RADIATION: Proton beam radiation therapy|DRUG: Pazopanib|DRUG: Ifosfamide|DRUG: Doxorubicin|DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Use of Methoxyflurane vs Placebo in the Management of Pain in Oral and Dental Emergencies in Adults: METODO (METhoxyflurane in ODOntology)
Status: NOT_YET_RECRUITING
Conditions: Dental Pain and Sensation Disorder
Interventions: DRUG: Experimenta group (standard of care + Methoxyflurane).|DRUG: control group (standard of care + placebo).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Omalizumab on Quality of Life Measures and Angioedema Occurrence in Patients With CSU Refractory to Therapy
Status: COMPLETED
Conditions: Chronic Spontaneous Urticaria|Angioedema
Interventions: BIOLOGICAL: Omalizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Windowed Casts With and Without Regranex® Gel for Healing Diabetic Neuropathic Ulcers
Status: UNKNOWN
Conditions: Diabetic Foot Ulcers
Interventions: DRUG: Regranex®|DRUG: Hydrogel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Project 2VIDA! COVID-19 Vaccine Intervention Delivery for Adults in Southern California
Status: COMPLETED
Conditions: Vaccine Refusal|Covid19
Interventions: BEHAVIORAL: COVID-19 Individual Awareness and Education.|BEHAVIORAL: COVID-19 Community Outreach & Health Promotion.|BEHAVIORAL: COVID-19 Individual Health Education & Linkages to Medical and Supportive Services.|BIOLOGICAL: Pop-up community vaccination sites
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Enhancing Response to MK-3475 in Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Oral CC-486|DRUG: Romidepsin|DRUG: MK-3475
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative aRCH With Cisplatin Versus aRCH With Cisplatin and Pembrolizumab in Locally Advanced Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: HNSCC
Interventions: DRUG: Pembrolizumab 25 MG/1 ML Intravenous Solution [KEYTRUDA]|OTHER: adjuvant radiochemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Recombinant Vaccinia Virus to Treat Unresectable Primary Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: GENETIC: JX-594: Recombinant vaccinia virus (TK-deletion plus GM-CSF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measuring the Effect of Remote Monitoring of Treatment Adherence on the Risk of Re-admission of Ambulatory Schizophrenic Patients
Status: UNKNOWN
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: OTHER: Tele-medicine monitoring of medication adherence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Viral Load Decay Rates in HIV Infected Participants Starting Treatment With Raltegravir (RAL) and Emtricitabine/Tenofovir Disoproxil Fumarate (TDF)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Raltegravir|DRUG: Emtricitabine/tenofovir disoproxil fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Advanced Patient Monitoring and A.I. Supported Outcomes Assessment in Lung Cancer Using Internet of Things Technologies (A.I. - APALITT)
Status: RECRUITING
Conditions: Non-small-cell Lung Cancer
Interventions: DEVICE: Fitbit charge
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Prefrontal Cortex Stimulation on Antisocial and Aggressive Behavior
Status: COMPLETED
Conditions: Antisocial Behavior|Aggression
Interventions: DEVICE: Transcranial direct current stimulation|DEVICE: Sham transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Imatinib and BL-8040 (Novel Anti CXCR4 Antagonist) for Improving Molecular Response in Chronic Myelogenous Leukemia
Status: WITHDRAWN
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: BL-8040
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Of NeuroNaute Smart System to a Standard EleCTroencephalogram System in Hospital
Status: WITHDRAWN
Conditions: Epilepsy
Interventions: DEVICE: GOLDSTANDARD|DEVICE: NEURONAUTE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intraperitoneal Bupivacaine With Magnesium or Nalbuphine for Postoperative Pain Control in Laparoscopic Hysterectomy
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Bupivacaine 0.25%|DRUG: Magnesium sulphate.|DRUG: nalbuphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Real-World Data Study to Evaluate the Effectiveness of OCA on Hepatic Outcomes in PBC Patients
Status: COMPLETED
Conditions: Primary Biliary Cholangitis
Interventions: DRUG: Obeticholic Acid 5 MG|DRUG: Obeticholic Acid 10 MG|DRUG: Standard of Care: UDCA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Ozone and Steroid Injection in Patients With Greater Trochanteric Pain Syndrome
Status: COMPLETED
Conditions: Trochanteric Bursitis
Interventions: DRUG: ozone injection|DRUG: betamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of PM8002 (Anti-PD-L1/VEGF) in Combination With Chemotherapy in Patients With NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: NSCLC
Interventions: DRUG: PM8002|DRUG: Placebo|DRUG: Carboplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Kefir on Bone Mineral Density and Bone Metabolism in Osteoporotic Patients
Status: COMPLETED
Conditions: Osteoporosis
Interventions: OTHER: Placebo|OTHER: CaCO3|OTHER: Kefir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Flaxseed Intervention on Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome X
Interventions: DIETARY_SUPPLEMENT: flaxseed|BEHAVIORAL: Health lifestyle counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safe Use of Heparin Sodium in Patients With Chronic Renal Failure.
Status: SUSPENDED
Conditions: Chronic Renal Failure
Interventions: BIOLOGICAL: Heparin sodic|BIOLOGICAL: heparin liquemine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Patients' Pain and Anxiety During a Hysterosalpingography Narratified by a Virtual Reality Helmet (Daphné)
Status: COMPLETED
Conditions: Salpingography|Virtual Reality Exposure Therapy|Virtual Reality|Pain|Anxiety
Interventions: DEVICE: Virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Study to Evaluate the Safety and Efficacy of PRX-08066 in Patients With Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease
Status: TERMINATED
Conditions: COPD|Pulmonary Hypertension
Interventions: DRUG: PRX-08066
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Diffusion of a Smoking Cessation Application Through an Online Network
Status: COMPLETED
Conditions: Use and Dissemination of Smoking Cessation Intervention|Cessation of Smoking
Interventions: BEHAVIORAL: Facebook app - condition t|BEHAVIORAL: Facebook app - condition z|BEHAVIORAL: Facebook app - condition B-active|BEHAVIORAL: Facebook app - condition B-passive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: BraveMind: Advancing the Virtual Iraq/Afghanistan PTSD Exposure Therapy
Status: COMPLETED
Conditions: Trauma|Post-Traumatic Stress Disorder
Interventions: BEHAVIORAL: Virtual Reality Exposure Therapy (VRET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DBS of Posterior Subthalamic Area (PSA) and Ventral Intermediate Nucleus (VIM) in Essential Tremor (ET)
Status: TERMINATED
Conditions: Essential Tremor
Interventions: DEVICE: VIM Stimulation|DEVICE: PSA Stimulation|DEVICE: VIM+PSA Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Genmont Probiotic on Improve the Level of Blood Glucose and Other Diabetic Associate Parameter in Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: OTHER: ADR-1|OTHER: GMNL-263|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ZD0473 and Doxorubicin in Treating Patients With Advanced Solid Tumors or Lymphoma
Status: COMPLETED
Conditions: Lymphoma|Small Intestine Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: pegylated liposomal doxorubicin hydrochloride|DRUG: picoplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Vaccination of Follicular Lymphomas With Tumor-Derived Immunoglobulin Idiotype
Status: COMPLETED
Conditions: B Cell Lymphoma|Follicular Lymphoma|Neoplasm
Interventions: DRUG: Id-KLH Vaccine|DRUG: QS-21 (Stimulation-QS-21) Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Second Line Bismuth Containing Quadruple Therapy With Supplementary Probiotic
Status: RECRUITING
Conditions: H.Pylori Gastrointestinal Disease
Interventions: DIETARY_SUPPLEMENT: Probiotics packets|DIETARY_SUPPLEMENT: Placebo packets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of 5 Fluorouracil and the Anti-Tumor Activity of ADH300004 and 5 Fluorouracil in Subjects With Incurable Solid Tumors
Status: SUSPENDED
Conditions: Neoplasms
Interventions: DRUG: ADH300004
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychoeducation Reaches HCV-infected Methadone/Buprenorphine Substituted Patients in Standard Antiviral Treatment
Status: COMPLETED
Conditions: Intravenous Drug Abuse|Chronic Hepatitis C
Interventions: BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Olaparib Combined With Cisplatin-based Chemoradiotherapy to Treat Locally Advanced Head and Neck Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer
Interventions: DRUG: Olaparib|DRUG: Cisplatin|RADIATION: IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial of Cognitive Remediation and D-cycloserine for Individuals With Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: OTHER: CR + DCS (D-cycloserine)|OTHER: CR + placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues.
Status: COMPLETED
Conditions: Trigeminal Neuralgia|Headache Disorders
Interventions: DRUG: Botulinum Toxin Type A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Flow Parameters With Placebo Easyhaler and Placebo HandiHaler
Status: COMPLETED
Conditions: Healthy Volunteer|COPD
Interventions: DRUG: Placebo Tiotropium inhalation powder type A|DRUG: Placebo Spiriva capsule|DRUG: Placebo Tiotropium inhalation powder type B|DEVICE: Substudy Placebo Tiotropium Easyhaler|DEVICE: Substudy Placebo Spiriva® via HandiHaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: XP1000 RF Therapy on Waist Circumference Reduction
Status: COMPLETED
Conditions: Circumferential Reduction|Waist Circumferential Reduction
Interventions: DEVICE: XP1000 RF|DEVICE: sham XP1000 RF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nab-Paclitaxel in Treating Older Patients With Locally Advanced or Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Breast Carcinoma|Metastatic Breast Carcinoma|Recurrent Breast Carcinoma|Stage III Breast Cancer AJCC v7|Stage IIIA Breast Cancer AJCC v7|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7|Stage IV Breast Cancer AJCC v6 and v7
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Nab-paclitaxel|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Accuracy and Usability of the Minuteful - Kidney Urine Analysis Test System in the Lay User Hands
Status: COMPLETED
Conditions: Albuminuria|Chronic Kidney Diseases|Diabetes|Hypertension
Interventions: DEVICE: Minuteful - Kidney Urine Analysis Test System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetic/Pharmacodynamic & Safety Study of G3041 and SEVIKAR® Tablet in Healthy Adult Volunteers
Status: UNKNOWN
Conditions: Healthy Adult Volunteers
Interventions: DRUG: G3041|DRUG: SEVIKAR®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multiple Dose Study To Determine Safety, Tolerability, and Pharmacokinetics Of PF-04634817 In Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-04634817|DRUG: PF-04634817|DRUG: PF-04634817|DRUG: PF-04634817|DRUG: PF-04634817|DRUG: PF-04634817
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study To Assess The Effect Of My Happy Flo On Alleviating Period Symptoms and Heavy Flows.
Status: ACTIVE_NOT_RECRUITING
Conditions: Menstrual Cramps|Women's Health|Fatigue
Interventions: DIETARY_SUPPLEMENT: My Happy Flo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RECELL® System Combined With Meshed Autograft for Reduction of Donor Skin Harvesting in Soft Tissue Reconstruction
Status: COMPLETED
Conditions: Full-thickness Skin Defects|Degloving Injuries|Crush Injuries|Laceration of Skin|Surgical Wound|Skin Cancer|Cellulitis|Infection|Necrotizing Fasciitis|Gun Shot Wound
Interventions: PROCEDURE: Control Intervention (Conventional Autograft)|DEVICE: Investigational Intervention (RECELL + more widely meshed autograft)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposome-Encapsulated Doxorubicin Citrate With or Without Gemcitabine Hydrochloride in Treating Patients With Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cavity Cancer
Status: UNKNOWN
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: liposome-encapsulated doxorubicin citrate|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Optimized Heparin Regimen in Vascular Surgery
Status: COMPLETED
Conditions: Peripheral Revascularisation
Interventions: PROCEDURE: ACT|PROCEDURE: TEG|PROCEDURE: Ankle-brachial index|PROCEDURE: Toe-brachial index|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: CD147-CAR T Cells for Relapsed/Refractory T Cell Non-Hodgkin's Lymphoma
Status: NOT_YET_RECRUITING
Conditions: T-cell Non-Hodgkin's Lymphoma
Interventions: DRUG: CD147- CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men to Test How BI 765080 is Taken up in the Body When Given as an Injection Under the Skin Compared With an Infusion Into the Vein
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 765080
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Profile of Acute Myeloid Leukemia Patients Receiving Azacitidine Plus Venetoclax Induction Chemotherapy
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspirate|OTHER: Electronic Health Record Review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Photocil (Topical) for the Treatment of Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Photocil for Atopic Dermatitis|OTHER: Placebo - Sunscreen (SPF 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dabrafenib and Pazopanib Hydrochloride in Treating Patients With Advanced Malignant Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: dabrafenib|DRUG: pazopanib hydrochloride|OTHER: Correlative studies
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Desloratadine With Oxybutynin for the Treatment of Seasonal Allergic Rhinitis and Post-Nasal Drip (Study P04258)(COMPLETED)
Status: COMPLETED
Conditions: Post-nasal Drip|Seasonal Allergic Rhinitis|Rhinorrhea
Interventions: DRUG: Desloratadine 2.5 mg|DRUG: Oxybutynin 2.5 mg|DRUG: Placebo for Desloratadine 2.5 mg|DRUG: Placebo for Oxybutynin 2.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Assess the Effects of a Mouthwash Containing Chlorine Dioxide on Oral Malodor
Status: COMPLETED
Conditions: Halitosis
Interventions: OTHER: Chlorine Dioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of the Decannulation Protocol With Suctioning and Capping in Severe Acquired Brain Injury Patients
Status: UNKNOWN
Conditions: Tracheostomy Decannulation|Acquired Brain Injury
Interventions: PROCEDURE: the Decannulation Protocol With Suctioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Tolerability of Multiple Ascending Doses of REGN1500
Status: COMPLETED
Conditions: Metabolic Disorders
Interventions: DRUG: REGN1500|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Hyaluronic Acid and Platelet-rich Plasma Injections
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: Hyaluronic acid injection|BIOLOGICAL: Platelet-rich plasma injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ivonescimab(AK112/SMT112) in Combination With Stereotactic Body Radiation Therapy and Chemotherapy in Patients With Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Ivonescimab|DRUG: Gemcitabine|DRUG: Nab paclitaxel|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Infusion of Terlipressin in Septic Shock
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: Terlipressin|DRUG: Vasopressin|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Insulin and Muscle Fat Metabolism
Status: TERMINATED
Conditions: Overweight and Obesity|Insulin Resistance|Metabolic Disease|Mitochondrial Metabolism|Sedentary Lifestyle
Interventions: OTHER: Hyperinsulinemic-euglycemic Clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Labor Induction With Double Balloon Device, Oral Misoprostol and Concomitant Use of Both
Status: TERMINATED
Conditions: Pregnancy Related
Interventions: DRUG: Misoprostol Oral Tablet|DEVICE: double balloon device for cervical ripening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of IV Casopitant For The Prevention Of Chemotherapy Induced Nausea And Vomiting.
Status: COMPLETED
Conditions: Nausea and Vomiting, Chemotherapy-Induced
Interventions: DRUG: Casopitant|DRUG: Dexamethasone|DRUG: Placebo|DRUG: Ondansetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vibratory Stimulation for the Treatment of Chronic Pain
Status: SUSPENDED
Conditions: Chronic Pain|Pelvic Pain|Functional Abdominal Pain Syndrome|Low Back Pain|Migraine
Interventions: DEVICE: Vibrotactile Stimulation|DEVICE: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characterising the Stable and Dynamic Left Atrial Substrate in Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DIAGNOSTIC_TEST: High density electrophysiological mapping|DIAGNOSTIC_TEST: Cardiac Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Usefulness of Imaging Methods and 3D Reconstruction in Percutaneous Closure Procedures of PVL.
Status: COMPLETED
Conditions: PVL - Paravalvular Leak
Interventions: DEVICE: Visualisation and measuring of paravalvular leak.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Tipifarnib in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome|Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Erythroid Leukemia (M6)|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monoblastic Leukemia and Acute Monocytic Leukemia (M5)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Cellular Diagnosis, Adult Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: tipifarnib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CyberCycling to Reduce Therapeutic Side Effects and Improve Quality of Life in AYA Cancers
Status: COMPLETED
Conditions: Adolescent and Young Adult Cancers
Interventions: BEHAVIORAL: CyberCycling|BEHAVIORAL: Stretching|BEHAVIORAL: Resistance Bands
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical And Economic Impact Of Upfront Plerixafor In Autologous Transplantation
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma|Multiple Myeloma
Interventions: DRUG: Plerixafor|DRUG: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study
Status: RECRUITING
Conditions: Cognitive Decline|Cognitive Impairment
Interventions: OTHER: Walnuts|OTHER: Simply White Diary-free chocolate bar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The FOrMe Registry (The German Focal Segmental Glomerulosclerosis and Minimal Change Disease Registry)
Status: RECRUITING
Conditions: Glomerulosclerosis, Focal Segmental|Minimal Change Disease|Idiopathic Nephrotic Syndrome
Interventions: OTHER: Biosampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Virtual Reality (VR) for Irritable Bowel Syndrome
Status: RECRUITING
Conditions: IBS - Irritable Bowel Syndrome
Interventions: DEVICE: Virtual Reality Headset
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Minocycline and Aspirin in the Treatment of Bipolar Depression
Status: COMPLETED
Conditions: Bipolar Disorder Depression
Interventions: DRUG: Minocycline|DRUG: Aspirin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of ENDOSWIR Device Versus Pathology for Squamous Cell Carcinoma of Upper Aerodigestive Tract (ENDOSWIR-VADS)
Status: UNKNOWN
Conditions: Head and Neck Neoplasms
Interventions: DEVICE: ENDOSWIR
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: De Quervain's Disease in the Acute Phase:a Study Aimed at Evaluating the Effectiveness of Standard Physiotherapy Treatment (HANDGUIDE), Compared to Experimental Treatment After Performing Ultrasound-guided Infiltrative Therapy.
Status: RECRUITING
Conditions: De Quervain Disease|Hand Tenosynovitis
Interventions: OTHER: Rehabilitation|OTHER: Standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Project CARE: An Integrated Treatment Adherence Program for Bipolar Disorder at the Time of Prison Release - Pilot RCT
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: BEHAVIORAL: CARE|OTHER: Treatment As Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of RO6889450 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Placebo|DRUG: RO6889450
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Buffered Lidocaine in Patients With Facial Swelling
Status: COMPLETED
Conditions: Orofacial Swelling
Interventions: DRUG: 4% lidocaine with 1:100,000 epinephrine|DRUG: 4% buffered lidocaine with 1:100,000 epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Carob Molasse Pose Flour and Germ On Glycemic Response and Antioxidant Capacity
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Participants
Interventions: COMBINATION_PRODUCT: Germ and Carob Molasses Pulp added standard whole wheat breads
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION