pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Inhaled NO as an Anti-inflammatory and Anti-reperfusion Agent in Infants and Children Undergoing Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Congenital Heart Disease
Interventions: DRUG: Nitric Oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Hyoscine Butylbromide on Shortening of First and Second Stages of Labor
Status: COMPLETED
Conditions: Labor
Interventions: DRUG: Hyoscine Butyl bromide|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase IV Comparing Rods of Yield Strengths to Correct Adolescent Idiopathic Scoliosis.
Status: WITHDRAWN
Conditions: Scoliosis
Interventions: DEVICE: titanium rod|DEVICE: ultra strength stainless steel rod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve Hypoplasia
Status: COMPLETED
Conditions: Growth Hormone Deficiency|Septo-Optic Dysplasia|Hypopituitarism
Interventions: DRUG: Nutropin AQ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Corticoids in Severe Community-Acquired Pneumonia (CAP)
Status: COMPLETED
Conditions: Community-Acquired Pneumonia
Interventions: DRUG: methylprednisolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Music as Analgesia During Neonatal Circumcision
Status: UNKNOWN
Conditions: Analgesia
Interventions: OTHER: Music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Comparison Between Primary and Secondary Flap Coverage in Extraction Sites: A Pilot Study
Status: COMPLETED
Conditions: Loss of Teeth Due to Extraction
Interventions: DEVICE: Cytoplast® TXT-200|DEVICE: MinerOss® Cortical and Cancellous Chips (FDBA)|PROCEDURE: Open Flap Technique|PROCEDURE: Closed Flap Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Influence of Hepatic Insufficiency on the Pharmacokinetics of Tozadenant
Status: TERMINATED
Conditions: Hepatic Impairment
Interventions: DRUG: Tozadenant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Intra and Extraluminal Bronchial Blocker in Adults
Status: COMPLETED
Conditions: Operative, Non Cardiac, Thoracic Disease
Interventions: PROCEDURE: Intraluminal Placement|PROCEDURE: Extraluminal Placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety, Pharmacokinetics, and Pharmacodynamics of MK-6325 in Hepatitis C Virus (HCV) Infections (MK-6325-003)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: MK-6325|DRUG: Placebo to MK-6325|DRUG: MK-6325|DRUG: Placebo to MK-6325|DRUG: MK-6325|DRUG: Placebo to MK-6325
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect on Bleeding When Using FloSeal Matrix™ in Subjects Undergoing Endoscopic Vein Harvest (EVH)
Status: TERMINATED
Conditions: Bleeding
Interventions: BIOLOGICAL: FloSeal Matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety and Pharmacokinetics of DMUC4064A in Participants With Platinum-Resistant Ovarian Cancer or Unresectable Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Neoplasms|Ovarian Neoplasms
Interventions: DRUG: DMUC4064A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Social Determinants and a Diabetes Prevention Program Tailored for African Americans
Status: RECRUITING
Conditions: PreDiabetes|Overweight and Obesity
Interventions: BEHAVIORAL: Culturally Tailored Diabetes Prevention Program|BEHAVIORAL: Culturally Tailored DPP Enhanced with Socioeconomic Supports|BEHAVIORAL: Diabetes Prevention Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of an Extended-Release, Crystalline Formulation of Recombinant Human Growth Hormone (ALTU-238) in Growth Hormone Deficient Adults to Determine Pharmacokinetics, Pharmacodynamics, and Drug Safety
Status: COMPLETED
Conditions: Adult Growth Hormone Deficiency
Interventions: DRUG: ALTU-238
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial Comparing Efficacy And Safety Of Sunitinib And Capecitabine
Status: TERMINATED
Conditions: Breast Neoplasms
Interventions: DRUG: Capecitabine|DRUG: Sunitinib malate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine, Cisplatin, and Celecoxib Treatment of Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Regional Block, Wound Infiltration and Caudal Block for Pain Management in Children
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: PROCEDURE: Regional block|PROCEDURE: Wound infiltration|PROCEDURE: Caudal block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Microwave Ablation With Cryoablation for Breast Tumor
Status: UNKNOWN
Conditions: Breast Tumor|Microwave Ablation|Cryoablation
Interventions: PROCEDURE: microwave ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 24-52-week Study to Evaluate the Long-term Efficacy and Safety of Saredutant in Patients With Depression (MAGENTA)
Status: COMPLETED
Conditions: Depressive Disorder
Interventions: DRUG: Saredutant (SR48968C)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Continuing Treatment for Participants Who Have Participated in a Prior Protocol Investigating Elotuzumab
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Elotuzumab|DRUG: Dexamethasone|DRUG: Dexamethasone|DRUG: Lenalidomide|DRUG: Bortezomib|DRUG: Pomalidomide|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Afatinib (BIBW 2992) in Advanced Non-Small Cell Lung Cancer Patients With EGFR Mutation
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Afatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Bright Light Therapy in Patients With Bipolar Depression and Eveningness
Status: RECRUITING
Conditions: Bipolar Depression
Interventions: DEVICE: Bright light therapy|DEVICE: Inactive negative ion generator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating HBM9036 Efficacy and Safety on Moderate to Severe Dry Eye
Status: UNKNOWN
Conditions: Dry Eye
Interventions: DRUG: HBM9036 0.25% Ophthalmic Solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Glucagon-like-peptide 1 (GLP-1) Receptor Agonism on Diabetic Kidney Disease
Status: COMPLETED
Conditions: Diabetic Kidney Disease
Interventions: DRUG: Liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognition and HRQoL in Adults With Highly-active RMS in Year 3 and 4 After Initial Mavenclad® Dose (CLARIFY MS Extension)
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Mavenclad®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Awakening in Spine Surgery: A Comparison Between Clinical Signs and Bispectral Index
Status: COMPLETED
Conditions: Spine Diseases
Interventions: DEVICE: bispectral index|DRUG: Target controlled infusion of propofol|DRUG: Fentanyl|DRUG: Atracurium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Continuation Study to Assess the Effect of CellCept in Patients With Myasthenia Gravis.
Status: COMPLETED
Conditions: Myasthenia Gravis Generalised
Interventions: DRUG: mycophenolate mofetil [CellCept]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing Durvalumab and FLOT Chemotherapy in Resectable Gastric and Gastroesophageal Junction Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastrointestinal Neoplasms|Esophagogastric Junction
Interventions: DRUG: Durvalumab|DRUG: FLOT chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraprocedural Intraaortic Embolic Protection With the EmbolX Device in Patients Undergoing Transaortic Transcatheter Aortic Valve Implantation
Status: COMPLETED
Conditions: Transaortic Transcatheter Aortic Valve Implantation
Interventions: DEVICE: Intra-aortic embolic protection management system; Embol-X
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Circuit Training and Retina
Status: COMPLETED
Conditions: Cognitive Impairment, Progressive|Cerebral Small Vessel Diseases
Interventions: BEHAVIORAL: High-Speed Circuit Resistance Training|BEHAVIORAL: Lecture on Diet, Exercise and Cognition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Betadine Rinses for Chronic Rhinosinusitis Prospective Cohort Study
Status: COMPLETED
Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: DRUG: Povidone-Iodine|DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Reproducibility Inter-observer of the Ultrasound Anomalies of the Salivary Glands in Sjogren's Disease
Status: COMPLETED
Conditions: Sjogren's Disease
Interventions: PROCEDURE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: The Efficacy and Safety of tDCS in Patients With Mild Dementia
Status: UNKNOWN
Conditions: Mild Dementia
Interventions: DEVICE: YMS-201B (Device: Mind STIM)|DEVICE: Sham stimulation using YMS-201B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Safety of Immune Globulin Subcutaneous Solution (IGSC) and rHuPH20 in PID
Status: COMPLETED
Conditions: Primary Immunodeficiency Diseases (PID)
Interventions: BIOLOGICAL: SC treatment with IGSC, 10% with rHuPH20 followed by SC/IGSC, 10% only (safety)|BIOLOGICAL: SC treatment with IGSC, 10% with rHuPH20 followed by IV/IGSC, 10% only (safety)|BIOLOGICAL: IV treatment with IGSC, 10%
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glyceryl Eicosapentaenoate Based Topic Products as an Irritant-free Cream and Serum for Hydration of Sensitive Skin
Status: RECRUITING
Conditions: Skin Dryness
Interventions: OTHER: Glyceryl Eicosapentaenoate serum|OTHER: Glyceryl Eicosapentaenoate Cream A|OTHER: Glyceryl Eicosapentaenoate Cream B|OTHER: Glyceryl Eicosapentaenoate Cream C
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neuroactive Steroids and Traumatic Brain Injury (TBI) in OEF/OIF Veterans
Status: COMPLETED
Conditions: Brain Injuries, Traumatic
Interventions: DRUG: Pregnenolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study Between PF-06410293 and Humira® in Combination With Methotrexate in Participants With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: PF-06410293|DRUG: adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The ELiSA Study - Evaluation of Lixivaptan in Subjects With Autosomal Dominant Polycystic Kidney Disease
Status: COMPLETED
Conditions: Autosomal Dominant Polycystic Kidney Disease
Interventions: DRUG: Lixivaptan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of GSK2982772 in Japanese Healthy Male Participants
Status: COMPLETED
Conditions: Autoimmune Diseases
Interventions: DRUG: GSK2982772|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics in Mild Alzheimer's Disease
Status: RECRUITING
Conditions: Neurodegenerative Diseases|Cognition Disorders in Old Age
Interventions: DRUG: Probiotic Blend Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Web Based Cardiac Rehabilitation Support in Coronary Artery Patients
Status: COMPLETED
Conditions: Cardiac Rehabilitation|Healthy Lifestyle|Medication Adherence|Quality of Life|Coronary Artery Disease
Interventions: OTHER: cardiac rehabilitation support program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Dexmedetomidine for Postoperative Intravenous Patient Controlled Analgesia
Status: UNKNOWN
Conditions: Patient-Controlled Analgesia
Interventions: DRUG: Dezocine|DRUG: Flubiprofen|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: PRELUDE-1 (Prospective Evaluation of Radiotherapy-induced Biologic Effects in Colorectal Cancer Oligometastatic Patients With LUng-limited Disease: Evolution of Cancer Genetics and Regulatory Immune Cells)
Status: RECRUITING
Conditions: Colorectal Cancer Metastatic
Interventions: DEVICE: Stereotactic Body Radiation Therapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Nipent, Cytoxan and Rituxan in the Treatment of Chronic Lymphocytic Leukemia.
Status: UNKNOWN
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Nipent, Cytoxan, Rituxan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conventional vs. Distal Radial Access Outcomes in STEMI Patients Treated by PCI
Status: RECRUITING
Conditions: STEMI - ST Elevation Myocardial Infarction|Myocardial Infarction|Acute Coronary Syndrome
Interventions: PROCEDURE: Radial Artery approach on percutaneous coronary intervention (PCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of OPC-34712 in Adults With Acute Schizophrenia
Status: COMPLETED
Conditions: Acute Schizophrenia
Interventions: DRUG: OPC-34712|DRUG: OPC-34712|DRUG: OPC-34712|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Alkaline Phosphatase on Renal Function in Septic Patients
Status: COMPLETED
Conditions: Severe|Septic|Shock
Interventions: DRUG: bolus injection, followed by a continuous infusion ( 24 h) (Alkaline phosphatase)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Modified Adaptive Servoventilation (ASV) Compared to Conventional ASV
Status: COMPLETED
Conditions: Periodic Breathing|Breathing-Related Sleep Disorder
Interventions: DEVICE: Modified Adaptive Servoventilation Device|DEVICE: Conventional Adaptive Servoventilation device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Icotinib as Neoadjuvant Therapy in EGFR-mutant Stage ⅢA-N2 Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: EGF-R Positive Non-Small Cell Lung Cancer
Interventions: DRUG: Icotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunonutrition and Tolerance to Chemoradiotherapy in Patients With Head-neck Cancer
Status: UNKNOWN
Conditions: Head and Neck Cancer
Interventions: DIETARY_SUPPLEMENT: Immunonutrition|DIETARY_SUPPLEMENT: Control Nutritional Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Dose Ranging, Evaluator-Blinded Study to Evaluate the Safety of Topical IDP-118
Status: UNKNOWN
Conditions: Plaque Psoriasis
Interventions: DRUG: IDP-118 Low Strength|DRUG: IDP-118 High Strength
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intramuscular Transplantation of Muscle Derived Stem Cell and Adipose Derived Mesenchymal Stem Cells in Patients With Facioscapulohumeral Dystrophy (FSHD)
Status: UNKNOWN
Conditions: Dystrophy
Interventions: BIOLOGICAL: Intramuscular injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ibrutinib + Obinutuzumab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Obinutuzumab|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Pyridoxal 5'-Phosphate for the Treatment of Patients With PNPO Deficiency
Status: RECRUITING
Conditions: Pyridox(am)Ine 5'-Phosphate Oxidase Deficiency
Interventions: DRUG: Pyridoxal Phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of a Messaging Application to Improve Oral Hygiene in Orthodontic Patients.ECA
Status: UNKNOWN
Conditions: Oral Hygiene|Mobiles Applications
Interventions: OTHER: whatsapp application with oral hygiene reminder for orthodontic patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Use of Expandeded Mesenchymal Stromal Cells (MSC) in Premature Ovarian Failure (POF) in Adult Humans
Status: UNKNOWN
Conditions: Premature Ovarian Failure
Interventions: BIOLOGICAL: expanded autologous bone marrow derived MSC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Tranexamic Acid (TA) vs Combined Oral Contraceptive (COCP) Pilot Study
Status: COMPLETED
Conditions: Menorrhagia
Interventions: DRUG: Oral tranexamic acid|DRUG: Oral Contraceptive Pills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Tranexamic Acid in Preventing Post Operative Blood Loss in Bone Sarcoma Patient
Status: RECRUITING
Conditions: Blood Loss, Surgical
Interventions: DRUG: Tranexamic acid injection|OTHER: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A 3 Way Cross-over Study Evaluating the Effects of ADOAIR Twice Daily Plus Tiotropium Bromide Once Daily Compared With the Individual Treatments of Japanese Subjects
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: fluticasone propionate/salmeterol|DRUG: tiotropium bromide|DRUG: fluticasone propionate/salmeterol plus tiotropium bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Effect of MK0217A on Vitamin D Inadequacy in Postmenopausal Women With Osteoporosis (0217A-262)
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: FOSAVANCE 5600 (Alendronate Sodium (+) cholecalciferol)|DIETARY_SUPPLEMENT: Calcium Supplement 500 mg|OTHER: Referred-Care Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Dry Eye Symptoms in CAE With Application of Intranasal Neurostimulation
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DEVICE: Intranasal Tear Neurostimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Maximal Usage Pharmacokinetics and Safety of ARQ-151 in Children With Plaque Psoriasis (ARQ-151-215)
Status: COMPLETED
Conditions: Psoriasis|Plaque Psoriasis
Interventions: DRUG: ARQ-151 cream 0.3%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Tranexamic Acid During Rhytidectomy
Status: UNKNOWN
Conditions: Bleeding|Bruising Face|Swelling Lips & Face
Interventions: DRUG: Tranexamic Acid 100Mg/Ml Inj Vil 10Ml|DRUG: Normal Saline 0.9% Infusion Solution Bag
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Teleheath tDCS Approach to Decrease Cannabis Use
Status: COMPLETED
Conditions: Cannabis Use Disorder|Multiple Sclerosis
Interventions: OTHER: Transcranial Direct Current Stimulation (tDCS)|OTHER: Sham - Transcranial Direct Current Stimulation (tDCS)|OTHER: Mindfulness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Dexmedetomidine for Cough Suppression in Patients Undergoing Thyroid Surgery
Status: UNKNOWN
Conditions: Anesthesia Complication
Interventions: DRUG: Dexmedetomidine Hydrochloride|DRUG: Normal Saline|DRUG: Dexmedetomidine Hydrochloride|DRUG: Dexmedetomidine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Daptomycin for the Emergency Department Treatment of Complicated Skin and Skin Structure Infections
Status: COMPLETED
Conditions: Cellulitis|Skin Infections
Interventions: DRUG: Daptomycin|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lung-MAP: Taselisib as Therapy in Treating Patients With Stage IV Squamous Cell Lung Cancer and Positive Biomarker Matches
Status: COMPLETED
Conditions: Recurrent Squamous Cell Lung Carcinoma|Stage IV Squamous Cell Lung Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Taselisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ondansetron as a Strategy for Reducing Propofol Injection Pain in Pediatrics: a Randomized Controlled Trial
Status: RECRUITING
Conditions: Injection Site Irritation
Interventions: DRUG: Ondansetron|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy in Alveolar Bone Regeneration With Autologous MSCs and Biomaterial in Comparison to Autologous Bone Grafting
Status: UNKNOWN
Conditions: Alveolar Bone Atrophy
Interventions: COMBINATION_PRODUCT: Advanced medicinal Therapy (MSC combined with biomaterial)|PROCEDURE: Autologous bone graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: This Study Performed to Develop a New Technique for Measuring the Intra Abdominal Pressure
Status: COMPLETED
Conditions: Abdominal Compartment Syndrome
Interventions: OTHER: Intraocular pressure measurement with 9 mmHg insufflation|OTHER: Intraocular pressure measurement with 12 mmHg insufflation|OTHER: Intraocular pressure measurement with 15 mmHg insufflation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: To Evaluate if the Medication Gabapentin Lessens Vulvar Pain
Status: TERMINATED
Conditions: Vulvar Pain Symptoms|Vulvodynia (Chronic Vulvar Pain)
Interventions: DRUG: Gabapentin|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Versus Clonidine for Transversus Abdominis Plane Block in Patients Undergoing Elective Caesarean Section
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: bupivacaine|DRUG: Dexmedetomidine|DRUG: clonidine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial of Ondansetron as a Parkinson's HAllucinations Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson's Hallucinations|Dementia With Lewy Bodies
Interventions: DRUG: Ondansetron 8mg or matched placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of Symbicort® pMDI, With or Without Spacer, in Children (6-11 Years) With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Budesonide/formoterol pMDI 40/2.25ug + spacer|DRUG: Budesonide/formoterol pMDI 40/2.25 ug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of LacTEST for the Diagnosis of Hypolactasia in Adults and Elderly Patients Presenting With Clinical Symptoms of Lactose Intolerance
Status: COMPLETED
Conditions: Lactose Intolerance
Interventions: DRUG: gaxilose|DIETARY_SUPPLEMENT: lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Compare the Pharmacokinetics, Efficacy, Safety, and Immunogenicity of Pembrolizumab (SB27, EU Sourced Keytruda, and US Sourced Keytruda) in Subjects With Stage II-IIIA NSCLC Following Complete Resection and Adjuvant Platinum-based Chemotherapy
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer Stage II|Non-small Cell Lung Cancer Stage IIIA
Interventions: DRUG: SB27|DRUG: EU sourced Keytruda|DRUG: US sourced Keytruda
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess All-Cause Mortality and Cardiovascular Morbidity in Participants With Chronic Kidney Disease (CKD) on Dialysis and Those Not on Renal Replacement Therapy Receiving Methoxy Polyethylene Glycol-Epoetin Beta (Mircera) or Reference Erythropoietin Stimulating Agents (ESAs)
Status: COMPLETED
Conditions: Chronic Renal Anemia
Interventions: DRUG: Darbepoetin Alfa|DRUG: Epoetin Alfa|DRUG: Epoetin Beta|DRUG: methoxy polyethylene glycol-epoetin beta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aromatase Inhibitors and Weight Loss in Severely Obese Men With Hypogonadism
Status: RECRUITING
Conditions: Hypogonadism, Hypogonadotropic|Obesity
Interventions: DRUG: anastrozole (1 mg/day)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Resilience Skills Self-Management for Chronic Pain.
Status: COMPLETED
Conditions: Chronic Spine Pain|Fibromyalgia
Interventions: BEHAVIORAL: Web-based Cognitive Behavioral Therapy (e-CBT) Self-Management|BEHAVIORAL: Promoting Resilience through Innovative Self-Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter RCT for BIliary Brushing: RX Cytology, BOSTON vs. Infinity®, US Endoscopy
Status: COMPLETED
Conditions: Biliary Stricture|Jaundice, Obstructive
Interventions: DEVICE: Biliary brushing with the RX Cytology brush, Boston Scientific|DEVICE: Biliary brushing with the Infinity® brush, US Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The NADAPT Study: a Randomized Double-blind Trial of NAD Replenishment Therapy for Atypical Parkinsonism
Status: RECRUITING
Conditions: Progressive Supranuclear Palsy|Multiple System Atrophy|Corticobasal Syndrome
Interventions: DIETARY_SUPPLEMENT: Nicotinamide Riboside|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigator Initiated Clinical Study to Explore the Efficacy and Safety of Human Placenta Hydrolysate in the Chronic Fatigue Patients
Status: COMPLETED
Conditions: Chronic Fatigue Syndrome|Idiopathic Chronic Fatigue
Interventions: DRUG: GCJBP Laennec Inj.|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between The Effect Of Aerobic Exercises On Land and Aerobic Exercises In Water On PMS Syndrome
Status: RECRUITING
Conditions: Premenstrual Syndrome
Interventions: OTHER: aerobic exercise on land|OTHER: aerobic exercise in water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PEEK Versus PFM Implant Supported Superstructure
Status: UNKNOWN
Conditions: PEEK Implant Supported Restoration
Interventions: OTHER: PEEK crown|OTHER: PFM Crown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Dose Study of KHK6640 in Japanese Patients With Alzheimer's Disease.
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: KHK6640|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Intramuscular HBIG Grifols for the Prevention of Recurrence After Liver Transplantation
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: intramuscular hepatitis B virus immune globulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Extension Study to Evaluate the Long-Term Safety and Durability of Effect of LUM001 in the Treatment of Cholestatic Liver Disease in Pediatric Subjects With Alagille Syndrome
Status: COMPLETED
Conditions: Alagille Syndrome
Interventions: DRUG: LUM001 (Maralixibat)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nab-Paclitaxel + Cisplatin + Gemcitabine + TTF in pt. w/ Metastatic PAC
Status: RECRUITING
Conditions: Pancreas Cancer|Metastatic Pancreatic Cancer|Pancreatic Adenocarcinoma|Metastatic Adenocarcinoma
Interventions: COMBINATION_PRODUCT: Modified GCN+TTF treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The ADDapt Diet in Reducing Crohn's Disease Inflammation
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn Disease|Inflammatory Bowel Diseases
Interventions: BEHAVIORAL: Dietary education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study in Patients With High-risk Recurrent Primary Hepatocellular Carcinoma Using Autologous TILs
Status: UNKNOWN
Conditions: Hepatic Carcinoma
Interventions: DRUG: Tumor infiltrating lymphocyte
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Bimagrumab and Semaglutide in Adults Who Are Overweight or Obese
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Obese|Overweight or Obesity
Interventions: BIOLOGICAL: Bimagrumab|DRUG: Semaglutide|OTHER: Bimagrumab Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Flaxseed in Treating Postmenopausal Women With Hot Flashes Who Have a History of Breast Cancer or Other Cancer or Who Do Not Wish to Take Estrogen Therapy
Status: COMPLETED
Conditions: Breast Cancer|Hot Flashes|Menopausal Symptoms|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DIETARY_SUPPLEMENT: flaxseed|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Benchmarking Initiative to Reduce Bronchopulmonary Dysplasia
Status: COMPLETED
Conditions: Infant, Newborn|Infant, Low Birth Weight|Infant, Small for Gestational Age|Infant, Premature|Bronchopulmonary Dysplasia (BPD)
Interventions: OTHER: Benchmarking Management Practices|OTHER: Standard Management Practices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Golimumab in Combination With Methotrexate (MTX) Versus MTX Monotherapy, in Improving Dactylitis, in MTX naïve Psoriatic Arthritis Patients
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Golimumab|DRUG: Methotrexate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Distribution & Dose Effect of Neoadjuvant Transarterial Chemoembolization With Doxorubicin in Prostate Cancer Patients Before Radical Prostatectomy
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: OTHER: Administration of embolization beads
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measuring Nerve Activity in Small Human Intestinal Biopsies in IBS (Irritable Bowel Syndrome)
Status: RECRUITING
Conditions: IBS|Healthy
Interventions: PROCEDURE: Rectal biopsies from IBS patients or healthy subjects will be taken during proctoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase III Trial BI 695502 Plus Chemotherapy vs. Avastin® Plus Chemotherapy in Patients With Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: BI 695502|DRUG: Avastin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Vildagliptin/Metformin Combination on Markers of Atherosclerosis, Thrombosis, and Inflammation in Diabetics With Coronary Artery Disease
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Ischemic Heart Disease
Interventions: DRUG: Metformin plus vildagliptin|DRUG: Metformin only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: User Satisfaction When Catheterizing With Hydrophilic Urinary Catheters From a More Sustainable Manufacturing Process.
Status: TERMINATED
Conditions: Bladder Voiding Dysfunction
Interventions: DEVICE: LoFric® OrigoTM and LoFric® SenseTM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PEEP and V/Q Mismatch in Premature Infants
Status: TERMINATED
Conditions: Respiratory Insufficiency Syndrome of Newborn|Infant, Premature, Diseases
Interventions: DEVICE: Positive end-expiratory pressure (PEEP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alpha Radiation Emitters Device for the Treatment of Recurrent Lung Cancer
Status: RECRUITING
Conditions: Recurrent Lung Cancer|Lung Cancer
Interventions: DEVICE: Radiation: Diffusing Alpha Radiation Emitters Therapy (DaRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tiotropium Efficacy Against Allergen Induced Early Asthmatic Responses
Status: COMPLETED
Conditions: Allergic Asthma
Interventions: DRUG: tiotropium bromide monohydrate (Spiriva Respimat)|DRUG: matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Acute Exercise Intensity and Pattern on Cytokine Function
Status: COMPLETED
Conditions: Inflammation
Interventions: OTHER: Moderate intensity continuous exercise|OTHER: High intensity continuous exercise|OTHER: High intensity interval exercise|OTHER: Resting (no exercise) control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Periodontal Status in Patients With Chronic Skin Diseases
Status: COMPLETED
Conditions: Periodontal Diseases|Psoriasis|Atopic Dermatitis|Autoimmune Bullous Dermatosis|Systemic Lupus Erythematosus
Interventions: DIAGNOSTIC_TEST: oral health status
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Oral Atogepant Tablets to Assess Safety and Efficacy in Adult Participants With Migraine
Status: RECRUITING
Conditions: Migraine
Interventions: DRUG: Atogepant|DRUG: Placebo for Atogepant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Photodynamic Therapy (PDT) in the Ablation of High-grade Dysplasia (HGD) in Barrett's Esophagus (BE)
Status: WITHDRAWN
Conditions: Barrett Esophagus
Interventions: DEVICE: Medlight PDT Balloon|PROCEDURE: Endoscopy|PROCEDURE: Endoscopy with biopsy|PROCEDURE: Electrocardiogram|PROCEDURE: Chest x-ray|PROCEDURE: Blood collection|PROCEDURE: Tissue sample collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quizartinib and High-dose Ara-C Plus Mitoxantrone in Relapsed/Refractory AML With FLT3-ITD
Status: TERMINATED
Conditions: AML According to WHO 2016 Classification (Except Acute Promyelocytic Leukemia) AND (Refractory to Induction Therapy OR Relapsed After First Line Treatment)
Interventions: DRUG: MRD-triggered arm|DRUG: Prophylactic Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improvement of Symptoms After Removal of the Essure® Contraceptive Implant
Status: NOT_YET_RECRUITING
Conditions: Implant Complication|Contraceptive Device; Complications
Interventions: DEVICE: Magnetic resonance imaging- Positron Emission Tomography (MRI-PET) examination|BIOLOGICAL: blood sample|BIOLOGICAL: urine collection|BIOLOGICAL: Collection of a lock of hair|OTHER: questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Focal Airway Disease in Asthma Using Image Guided Bronchoscopy
Status: WITHDRAWN
Conditions: Asthma|Mucus; Plug, Tracheobronchial
Interventions: RADIATION: Multidetector Computed Tomography (MDCT) Scan|PROCEDURE: Virtual Navigation Bronchoscopy (VNB)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vasodilator and Exercise Study for DMD (VASO-REx)
Status: RECRUITING
Conditions: Duchenne Muscular Dystrophy|Duchenne Disease|Muscular Dystrophy|Muscular Dystrophy in Children|Vasodilation|Exercise|DMD
Interventions: DRUG: Tadalafil|DRUG: Placebo|OTHER: Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Induction and Consolidation Chemotherapy in Patients With Locally Advanced CRM-positive Rectal Cancer
Status: ENROLLING_BY_INVITATION
Conditions: Rectal Neoplasms Malignant|Rectum Carcinoma|Rectal Cancer
Interventions: DRUG: Capecitabine|DRUG: Oxaliplatin|DRUG: Capecitabine|RADIATION: Radiotherapy|PROCEDURE: Rectal cancer surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Avastin (Bevacizumab) and RAD001 (Everolimus) in Advanced Low or Intermediate Grade Neuroendocrine Carcinoma
Status: COMPLETED
Conditions: Neuroendocrine Carcinoma
Interventions: DRUG: Avastin|DRUG: RAD001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ubiquinol in Parkinson's Disease: Safety, Tolerability, and Effects Upon Oxidative Damage and Mitochondrial Biomarkers
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Ubiquinol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label Study of Oral Paliparidone for the Treatment of Patients With Co-occurring Opioid and ATS Dependence
Status: UNKNOWN
Conditions: Heroin Dependence|Amphetamine Dependence
Interventions: DRUG: paliparidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: T-Wave Alternans in Patients With Suspected Acute Coronary Syndrome
Status: COMPLETED
Conditions: Chest Pain|Acute Coronary Syndrome|Acute Myocardial Infarction
Interventions: DEVICE: Observational Measurement of T-wave Alternans|DEVICE: T-wave Alternans
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vaccine Therapy Followed by Biological Therapy in Treating Patients With Stage III or Stage IV Melanoma
Status: TERMINATED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: MART-1 antigen|BIOLOGICAL: aldesleukin|BIOLOGICAL: gp100 antigen|BIOLOGICAL: recombinant CD40-ligand|BIOLOGICAL: recombinant interferon gamma|BIOLOGICAL: recombinant interleukin-4|BIOLOGICAL: sargramostim|BIOLOGICAL: therapeutic autologous dendritic cells|BIOLOGICAL: therapeutic tumor infiltrating lymphocytes|BIOLOGICAL: tyrosinase peptide|RADIATION: Candida albicans skin test reagent
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Long Term Cardio-Vascular Risk Assessment in CKD and Kidney Transplanted Patients Following SARS-COV-2
Status: UNKNOWN
Conditions: CKD|Dialysis|Kidney Transplant|COVID-19|Cardiovascular Disease|Endothelial Dysfunction
Interventions: DIAGNOSTIC_TEST: FMD|DIAGNOSTIC_TEST: Arterial stiffness|DIAGNOSTIC_TEST: Assessment of IMT|DIAGNOSTIC_TEST: Echocardiography|DIAGNOSTIC_TEST: LUS|DIAGNOSTIC_TEST: BIS analysis|OTHER: Biomarkers determination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p