pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: This Study Will Evaluate The Relationship Between Plasma Drug Levels And Receptor Binding In Brain Using PET (Positron Emission Tomography) In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-05212377
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Anti-CD19 iCAR NK Cells in Relapsed and Refractory B Cell Lymphoma
Status: UNKNOWN
Conditions: Refractory B-Cell Lymphoma
Interventions: BIOLOGICAL: Anti-CD19 iCAR NK Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Peripheral Neuromodulation for Neurogenic Bladder
Status: COMPLETED
Conditions: Urinary Bladder, Neurogenic
Interventions: DEVICE: EV-906 Digital Transcutaneous electrical nerve stimulation (TENS) machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: the Efficacy and Safety of Indobufen and Low-dose Aspirin in Different Regimens of Antiplatelet Therapy
Status: UNKNOWN
Conditions: Coronary Atherosclerosis
Interventions: DRUG: aspirin 100mg/d therapy|DRUG: aspirin 100mg/2d therapy|DRUG: aspirin 100mg/3d therapy|DRUG: aspirin 50mg bid therapy|DRUG: aspirin 75mg/d therapy|DRUG: aspirin 50mg/d therapy|DRUG: indobufen 100mg bid therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: HoLEP Prior to Radiation Therapy for Patients With LUTS/Retention and Concurrent Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer|Lower Urinary Tract Symptoms
Interventions: PROCEDURE: Holmium Laser Enucleation of Prostate (HoLEP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy And Safety Of Dysport In The Treatment Of Upper Limb Spasticity In Children
Status: COMPLETED
Conditions: Upper Limb Spasticity (Altered Skeletal Muscle Performance) in Children
Interventions: BIOLOGICAL: Botulinum toxin type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Cranial-caudal Mixed Medial Approach for Laparoscopic Right Hemicolectomy
Status: COMPLETED
Conditions: Intraoperative Blood Loss|Postoperative Complications|Pathology
Interventions: PROCEDURE: The cranial-caudal mixed medial approach
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Characteristics of Spinal Levobupivacaine: Hyperbaric Compared With Isobaric Solution
Status: COMPLETED
Conditions: Observation of Neuromuscular Block|Disease (or Disorder); Gynecological
Interventions: DRUG: isobaric levobupivacaine|DRUG: hyperbaric levobupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Influenza Vaccine To Prevent Adverse Vascular Events (RCT-IVVE)
Status: UNKNOWN
Conditions: Heart Failure|Influenza
Interventions: OTHER: Sterile saline|DRUG: inactivated trivalent influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 68Ga-FAPI-46 PET for Imaging of FAP Expressing Cancer
Status: COMPLETED
Conditions: Tumor, Solid
Interventions: DIAGNOSTIC_TEST: 68Ga-FAPI-46 PET Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Cold Dialysis in Combination With Intradialytic Exercise in Aspects Related to Quality of Life and Health
Status: COMPLETED
Conditions: End Stage Renal Failure on Dialysis
Interventions: PROCEDURE: Cold Dialysis|PROCEDURE: Typical Dialysis|PROCEDURE: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Gemcitabine and Carboplatin (Plus Herceptin in Human Epidermal Growth Factor Receptor 2 Positive [HER2+] Patients) With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Gemcitabine|DRUG: Carboplatin|DRUG: Herceptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studies Evaluating the Effects of Itraconazole or Rifampicin on the Pharmacokinetics of TY-9591 Tablets in Healthy Subjects
Status: RECRUITING
Conditions: NSCLC
Interventions: DRUG: Itraconazole|DRUG: Rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selective Screening of Children for Hereditary Metabolic Diseases by Tandem Mass Spectrometry in Kazakhstan
Status: RECRUITING
Conditions: Propionic/Methylmalonic Acidemias|Maple Syrup Urine Disease|Citrullinemia|Argininosuccinic Aciduria|Ornithine Transcarbamylase Deficiency|Carbamoyl Phosphate Synthetase I Deficiency|N-acetylglutamate Synthase Deficiency|Nonketotic Hyperglycinemia|Tyrosinemia|Homocystinuria|Arginase Deficiency|Isovaleric Acidemia|Short/Branched Chain Acyl-CoA Dehydrogenase Deficiency|Isobutyryl-CoA Dehydrogenase Deficiency|Glutaric Acidemia Type I|3-methylcrotonyl-CoA Carboxylase Deficiency|Biotinidase Deficiency|Malonyl-CoA Decarboxylase Deficiency|Beta-ketothiolase Deficiency|3-hydroxy-3-methylglutaryl-CoA Lyase Deficiency|3-methylglutaconyl-CoA Hydratase Deficiency|Medium-chain Acyl-CoA Dehydrogenase Deficiency|Very Long-chain Acyl-CoA Dehydrogenase Deficiency|Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency|Glutaric Acidemia Type II|Primary Carnitine Deficiency|Carnitine Palmitoyltransferase I Deficiency|Carnitine Palmitoyltransferase II Deficiency|Carnitine-acylcarnitine Translocase Deficiency
Interventions: DIAGNOSTIC_TEST: Obtaining Dry Blood Spots From Healthy Newborns (Aged 1-7 Days)|DIAGNOSTIC_TEST: Obtaining Dry Blood Spots From Healthy Children Aged 8 Days - 7 Years|DIAGNOSTIC_TEST: Obtaining Dry Blood Spots From Healthy Children Aged 8-18 Years|DIAGNOSTIC_TEST: Obtaining Dry Blood Spots From High-risk Newborns (Aged 1-7 Days)|DIAGNOSTIC_TEST: Obtaining Dry Blood Spots From High-risk childrens (Aged 8 Days- 7 years)|DIAGNOSTIC_TEST: Obtaining Dry Blood Spots From High-risk childrens (Aged 8 - 18 years)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Neoplasms|Breast Cancer|HER2-positive Early Breast Cancer
Interventions: DRUG: Trastuzumab Deruxtecan|DRUG: Paclitaxel|DRUG: Trastuzumab|DRUG: Pertuzumab|DRUG: Doxorubicin|DRUG: cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cisplatin and Etoposide With or Without Veliparib in Treating Patients With Extensive Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Extensive Stage Small Cell Lung Carcinoma|Large Cell Lung Carcinoma|Neuroendocrine Carcinoma|Small Cell Carcinoma|Stage IV Non-Small Cell Lung Cancer AJCC v7
Interventions: DRUG: Cisplatin|DRUG: Etoposide|DRUG: Veliparib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-CTLA-4 Antibody Followed by Anti-PD-1 Antibody in Recurrent or Metastatic NSCLC
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Ipilimumab|DRUG: SHR-1210
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: tDCS in Treatment of Craving in Sexual Addiction
Status: NOT_YET_RECRUITING
Conditions: Sexual Addiction|Hypersexualism
Interventions: DEVICE: Active Trans-cranial direct current stimulation (tDCS)|DEVICE: Sham Trans-cranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Adapted Yoga in Managing Psychosocial Risk in Implantable Cardioverter Defibrillator (ICD) Patients
Status: COMPLETED
Conditions: Cardiac Arrhythmias
Interventions: BEHAVIORAL: Adapted Yoga Intervention for Implantable Cardioverter Defibrillator (ICD) Recipients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Anterior Knee Pain Between Unisex Knee Prosthesis VS Gender Specific Knee Prosthesis Following MIS TKA
Status: COMPLETED
Conditions: Osteo Arthritis Knee|Knee Pain Chronic
Interventions: PROCEDURE: Gender Solution®posterior stabilized NexGen® LPS Hi-Flex; Zimmer Biomet, Inc, Warsaw, IN, USA and standard posterior stabilized NexGen® LPS Hi-Flex; Zimmer Biomet, Inc, Warsaw, IN, USA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of Piezocision and Micro-osteoperforation in Alleviating Mandibular Anterior Crowding
Status: UNKNOWN
Conditions: Crowding of Anterior Mandibular Teeth
Interventions: PROCEDURE: GROUP - A: PIEZOCISION GROUP|PROCEDURE: GROUP- B: MICRO-OSTEOPERFORATION GROUP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Adipose Derived Stem Cells for Chronic Obstructive Pulmonary Disease
Status: WITHDRAWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: PROCEDURE: Lipoaspiration with Local anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real World Study on the Application of Appropriate Electrophysiological Technology in the Diagnosis and Treatment of Andrology Diseases in Northwest China
Status: UNKNOWN
Conditions: Chronic Pelvic Pain|Chronic Prostatitis
Interventions: DRUG: Percutaneous electrical nerve stimulation treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Project Osteoarthritis: Recovering Quality of Life Through Education
Status: COMPLETED
Conditions: Osteoarthritis|Knee Osteoarthritis
Interventions: BEHAVIORAL: Educational Course|BEHAVIORAL: Phone Calls|BEHAVIORAL: Printed Material
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: FOcus on Reducing Dose-limiting Toxicities in Colon Cancer With Resistance Exercise Study
Status: COMPLETED
Conditions: Resistance Training|Colon Cancer|Chemotherapy Effect
Interventions: BEHAVIORAL: Resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Validation Study of Genzyme Diagnostics OSOM Trichomonas Rapid Test and BVBlue Test
Status: COMPLETED
Conditions: Bacterial Vaginosis|Urogenital Infection by Trichomonas Vaginalis
Interventions: DEVICE: OSOM Trichomonas Rapid Test|DEVICE: OSOM BVBlue Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Casting Materials for the Treatment of Clubfoot Using the Ponseti Method
Status: COMPLETED
Conditions: Clubfoot|Ponseti Method|Talipes Equinovarus|Casting
Interventions: DEVICE: Plaster of Paris (POP) casting using the Ponseti Method|DEVICE: Semi-Rigid Fiberglass softcast using the Ponseti Method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Using Regorafenib as Second or Third Line Therapy in Metastatic Medullary Thyroid Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Thyroid Cancer
Interventions: DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Feasibility and Safety Study of Dual Specificity CD38 and BCMA CAR-T Cell Immunotherapy for Relapsed or Refractory Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: Dual Specificity CD38 and bcma CAR-T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rollover Study to Evaluate the Safety and Efficacy of Long-term Treatment With Lumacaftor in Combination With Ivacaftor
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: LUM/IVA|DRUG: LUM/IVA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Anxiety at Oocyte Retrieval
Status: COMPLETED
Conditions: Infertility, Female|Anesthesia Awareness|Anxiety State
Interventions: DEVICE: Monitoring brain function|DRUG: propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: C1-Esteraseremmer-N for the Treatment of Hereditary (and Acquired) Angioedema
Status: COMPLETED
Conditions: Angioedema
Interventions: DRUG: C1 inhibitor concentrate (C1-esteraseremmer-N)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Imiquimod in Conjunction With Nd:YAG Laser for Tattoo Removal
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: 1064 nm Nd:YAG laser|DRUG: Imiquimod, 5% cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Masitinib in Locally Advanced/Metastatic Gastro-intestinal Stromal Tumour (GIST)
Status: COMPLETED
Conditions: Gastro-intestinal Stromal Tumours
Interventions: DRUG: oral masitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Surfactant Administration by Laryngeal Mask Airway (LMA)
Status: TERMINATED
Conditions: Respiratory Distress Syndrome, Newborn
Interventions: DEVICE: Surfactant administered via Laryngeal Mask Airway (LMA)|OTHER: standard of care (nasal CPAP and supplemental oxygen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Reduced Intensity Stem Cell Transplantation in Children With Relapsed Neuroblastoma After Autologous Transplantation
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: PROCEDURE: Reduced-intensity allogeneic hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study Assessing Chronic Hepatitis C Management in Clinical Practice in Italy (Study P05488 AM1)
Status: COMPLETED
Conditions: Hepatitis C|Hepatitis C, Chronic
Interventions: BIOLOGICAL: Peginterferon alfa-2b|DRUG: Ribavirin|BIOLOGICAL: Peginterferon alfa-2a
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Abuse Liability of Very Low Nicotine (VLN) Cigarettes
Status: COMPLETED
Conditions: Tobacco Use
Interventions: OTHER: VLN cigarettes (A)|OTHER: Usual Brand Cigarettes (B)|DRUG: Nicotine gum (C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Long-Term Safety Study Of Tofacitinib In Patients With Juvenile Idiopathic Arthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Juvenile Idiopathic Arthritis
Interventions: DRUG: Tofacitinib|DRUG: Tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Low-risk Aneurysm Stereotactic Radiosurgical Trial
Status: RECRUITING
Conditions: Intracranial Aneurysm
Interventions: PROCEDURE: Stereotactic RadioSurgery (SRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Shoulder Anterior Capsule and Suprascapular Nerve Block Versus Interscalene Block in Shoulder Surgery
Status: NOT_YET_RECRUITING
Conditions: Shoulder Pain
Interventions: OTHER: suprascapular nerve block with 10 ml bupivacaine 0.25% & shoulder anterior capsule block with 30 ml bupivacaine 0.25%|OTHER: Interscalene block with 20 ml bupivacaine 0.25%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase IIB Rheumatoid Arthritis Dose Ranging Study for BMS-945429 in Subjects Who Are Not Responding to Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: BMS-945429 Placebo|BIOLOGICAL: BMS-945429|BIOLOGICAL: BMS-945429|BIOLOGICAL: BMS-945429|BIOLOGICAL: BMS-945429|DRUG: Methotrexate|DRUG: Methotrexate|DRUG: Methotrexate Placebo|DRUG: Methotrexate|DRUG: Adalimumab Placebo|DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Evaluating the Safety and Efficacy of Moxidectin 2 mg Ivermectin-controlled in Loa Loa Microfilaremic Patients
Status: UNKNOWN
Conditions: Onchocerciasis, Ocular|Loiasis
Interventions: DRUG: Moxidectin 2 MG Oral Tablet|DRUG: Ivermectin 3Mg Tab|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyperinsulinemia in Prediabetes Mediated by Interleukin-1β
Status: RECRUITING
Conditions: Hyperinsulinemia|PreDiabetes
Interventions: DRUG: Anakinra|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Educational Plan Prepared According to the Health Literacy Levels of Patients
Status: COMPLETED
Conditions: Total Knee Arthroplasty|Patient Education
Interventions: OTHER: Patient Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: POLESTAR Trial - An International Multi-center Early Discharge TAVI Program
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: Transcatheter Aortic Valve Implantation with ACURATE Neo Aortic Bioprosthesis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: E7 TCR T Cell Induction Immunotherapy for Stage IIB-IVA Cervical Cancer
Status: TERMINATED
Conditions: Uterine Cervical Neoplasms
Interventions: BIOLOGICAL: E7 T-Cell Receptor (TCR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The PK/PD, Efficacy, Safety and Tolerability Study of SHR3824 in Type 2 Diabetes Mellitus Patients
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: SHR3824|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study to Compare Co-administration of Repaglinide and Metformin HCl to Administration of Combination Preparation of Those Two Components
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Repaglinide/Metformin combination, Repaglinide, Metformin|DRUG: Repaglinide/Metformin combination, Repaglinide, Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRF and Connective Tissue Graft in Interdental Papilla Reconstruction
Status: UNKNOWN
Conditions: Reconstructive Surgery
Interventions: PROCEDURE: interdental papilla reconstructive surgery with PRF|PROCEDURE: interdental papilla reconstructive surgery with subepithelial connective tissue graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Individualized PEEP in Thoracic Surgery
Status: COMPLETED
Conditions: Thoracic Surgery|One-lung Ventilation|Respiratory Mechanics|Artificial Respiration
Interventions: PROCEDURE: Best PEEP|PROCEDURE: Standard PEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RAD001 (Everolimus) and Pasireotide (SOM230) LAR in Patients With Advanced Uveal Melanoma
Status: COMPLETED
Conditions: Uveal Melanoma
Interventions: DRUG: RAD001 (Everolimus) and Pasireotide (SOM230) LAR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on Comparison of Glargine Plus Glulisine With Premixed Insulin in Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Type2 Diabetes
Interventions: DRUG: Glargine + Glulisine|DRUG: Premixed analogue insulin (70/30)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability of Maralixibat in Infant Participants With Cholestatic Liver Diseases Including Progressive Familial Intrahepatic Cholestasis (PFIC) and Alagille Syndrome (ALGS).
Status: ACTIVE_NOT_RECRUITING
Conditions: Progressive Familial Intrahepatic Cholestasis|Alagille Syndrome|Cholestatic Liver Disease
Interventions: DRUG: Maralixibat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CS1003 in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: BIOLOGICAL: CS1003|BIOLOGICAL: CS1003|DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Biologic Impact (Pharmacodynamics) of Repeated Injections and Increasing Amounts of UPB-101 in Asthmatics
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: UPB-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HYDRAFIL-D: HYDRogel Augmentation For Intervertebral Lumbar Discs
Status: NOT_YET_RECRUITING
Conditions: Degenerative Disc Disease (DDD)
Interventions: DEVICE: The ReGelTec HYDRAFIL™ System|OTHER: Conservative Care Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of ABT-263 in Combination With Dose-Intensive Rituximab, or Dose-Intensive Rituximab Alone, in Previously Untreated Patients With B-Cell, Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: ABT-263|DRUG: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vemurafenib (R05185426) in Poor Performance Status Patients With Unresectable Locally Advanced or Metastatic Melanoma Harboring a V600E/K Mutation
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of COX-inhibiting Drugs on Skeletal Muscle Adaptations to Resistance Exercise in Healthy Adults
Status: COMPLETED
Conditions: Skeletal Muscle Mass Regulation
Interventions: DRUG: Ibuprofen|DRUG: Acetylsalicylic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Toripalimab (JS001) Combined With Pemetrexed and Anlotinib for Patients With T790M Positive Non-Small Cell Lung Cancer After Osimertinib Resistance
Status: UNKNOWN
Conditions: IIIb/IV NSCLC With T790M Positive Mutations Failed to Osimertinib Therapy
Interventions: DRUG: Toripalimab + Pemetrexed + Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Normovolemic Hemodilution in Patients Undergoing Cytoreductive Surgery for Advanced Ovarian Cancer
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Carcinoma
Interventions: PROCEDURE: Acute Normovolemic Hemodilution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pseudomonas Aeruginosa for Intermediate and High-risk Non-muscle Invasive Bladder Cancer
Status: RECRUITING
Conditions: Bladder Cancer
Interventions: DRUG: Pseudomonas aeruginosa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the PK, Safety and Tolerability of GMI-1271 With and Without Filgrastim in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: GMI-1271|DRUG: Filgrastim|DRUG: Placebo Injection|DRUG: Placebo Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Fibrin Monomer Compared With Hemostatic Sponge in the Integrity of the Graft During Tympanoplasty
Status: COMPLETED
Conditions: Tympanic Membrane Perforation
Interventions: PROCEDURE: Fibrin monomer|PROCEDURE: Hemostatic sponge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Improvement of Urinary Retention Symptoms With Electroacupuncture Therapy
Status: COMPLETED
Conditions: Urinary Retention
Interventions: OTHER: true electroacupuncture|OTHER: sham electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of SPGB on ICP and Oxygenation of Cerebral Venous Outflow in Craniotomy for Cerebral Tumors.
Status: COMPLETED
Conditions: Cerebral Tumor
Interventions: PROCEDURE: SPGB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Staccato Alprazolam in Panic Attack
Status: COMPLETED
Conditions: Treatment of Induced Panic Attack
Interventions: DRUG: Inhaled placebo|DRUG: Inhaled alprazolam 1 mg|DRUG: Inhaled alprazolam 2 mg|DRUG: IV doxapram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Explore the Efficiency of Fiberscope-guided Nasogastric Tube Insertion
Status: COMPLETED
Conditions: Nasogastric Tube Esophagitis
Interventions: DEVICE: Fiberscope-Guided Nasogastric tube insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Omission of SLNB in Triple-negative and HER2-positive Breast Cancer Patients With rCR and pCR in the Breast After NAST
Status: RECRUITING
Conditions: Breast Cancer Female|Breast Cancer
Interventions: PROCEDURE: omission of SLNB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Catheter-Associated Infection With the Skin Disinfectant Octenidine Dihydrochloride
Status: COMPLETED
Conditions: Catheterization, Central Venous|Catheter-Associated Infections|Bacterial Infections|Bacteremia
Interventions: DRUG: 0.1% Octenidine with 30% 1-propanol and 45% 2-propanol|DRUG: 74% Ethanol with 10% 2-propanol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess Efficacy, Safety, and Tolerability of P1101 in Adult Patients With PV
Status: RECRUITING
Conditions: Polycythemia Vera
Interventions: DRUG: P1101 (Ropeginterferon alfa-2b-njft)|DRUG: Ropeginterferon alfa-2b-njft (P1101)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BDP/FF Versus Formoterol Fumarate (FF) in Patients With Severe COPD (Lung Function and Exacerbation Rate)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: CHF1535|DRUG: Formoterol fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Phenazopyridine Hydrochloride Tablets, USP 200 mg as an Analgesic for Short-Term Treatment in Female Subjects Suffering From Moderate-to-Severe Pain and Burning Upon Urination Associated With Uncomplicated Urinary Tract Infections (uUTI)
Status: COMPLETED
Conditions: Uncomplicated Urinary Tract Infections
Interventions: DRUG: Placebo of Phenazopyridine Hydrochloride Tables, USP 200 mg|DRUG: Phenazopyridine Hydrochloride Tables, USP 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Therapy for Treating Attention Deficit Hyperactivity Disorder
Status: RECRUITING
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: Multitask game-based digital therapy|BEHAVIORAL: Schulte Grid digital game
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ATCell™ Expanded Autologous, Adipose-Derived Mesenchymal Stem Cells Deployed Via Intravenous Infusion
Status: ACTIVE_NOT_RECRUITING
Conditions: Post-Concussion Syndrome
Interventions: DRUG: 50 Adipose Derived Stem Cell Infusion|DRUG: 150 Adipose Derived Stem Cell Infusion|DRUG: 300 Adipose Derived Stem Cell Infusion|DRUG: Placebo Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Gemtuzumab Ozogamicin (GO)-Gilteritinib Combination in Adults With FLT3-ITD Relapse/Refractory (R/R) AML
Status: RECRUITING
Conditions: AML
Interventions: COMBINATION_PRODUCT: Gemtuzumab ozogamicine - Cytarabine - Gilteritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Erector Spinae Plane Block in Posterior Thoraco- Lumbar Spinal Decompression Surgery
Status: UNKNOWN
Conditions: Spinal Surgery
Interventions: PROCEDURE: Erector Spinae Plane Block - Ultrasound guided
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endovascular Carotid Body Ablation in Patients With Treatment- Resistant Hypertension: A Safety and Feasibility Study
Status: UNKNOWN
Conditions: Hypertension
Interventions: DEVICE: Carotid body ablation (Cibiem)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Community Health Worker Performance With a Supervision Dashboard
Status: COMPLETED
Conditions: Community Health Worker Performance
Interventions: OTHER: The CHW-led health system|OTHER: The CHW Supervision model|OTHER: The CHW Performance Dashboard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Probiotics Improve Gastrointestinal Symptoms After Roux-en-Y Gastric Bypass: A Prospective Randomized Trial
Status: UNKNOWN
Conditions: Morbid Obesity
Interventions: DIETARY_SUPPLEMENT: probiotics,digestive enzyme
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Copanlisib in Combination With T-DM1 in Pretreated Unresectable Locally Advanced or Metastatic HER2-positive Breast Cancer
Status: TERMINATED
Conditions: HER2-positive Breast Cancer|Metastatic Breast Cancer|Locally Advanced Breast Cancer|Unresectable Breast Cancer
Interventions: DRUG: Copanlisib|DRUG: Trastuzumab emtansine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Access II - Trial of Warfarin to Prevent Malfunction of Haemodialysis Catheters
Status: COMPLETED
Conditions: End Stage Renal Disease|Thrombosis|Bleeding
Interventions: DRUG: warfarin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Single Injection of Ganirelix in Gonadotropin Intrauterine Insemination (IUI) Cycles
Status: COMPLETED
Conditions: Compare Pregnancy Rates Between FSH Stimulation and FSH and|GnRH Antagonist
Interventions: DRUG: Follistim administration|DRUG: Follistim plus Ganirelix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Zavesca® in Patients With Pompe Disease and Infusion Associated Reaction
Status: TERMINATED
Conditions: Pompe Disease|Hypersensitivity Reaction
Interventions: DRUG: Zavesca® Prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety of Rituximab in Combination With Other Anti-Rheumatic Drugs in Subjects With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Rituximab|DRUG: Anti-inflammatory drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of AbGn-107 in Patients With Gastric, Colorectal, Pancreatic or Biliary Cancer
Status: TERMINATED
Conditions: Gastric Cancer|Colorectal Cancer|Pancreatic Cancer|Biliary Cancer
Interventions: BIOLOGICAL: AbGn-107
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Oxaliplatin Capecitabine and Pre-operative Radiotherapy for Patients With Locally Advanced and Inoperable Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DRUG: Oxaliplatin, Capecitabine|PROCEDURE: Pre operative radiotherapy|PROCEDURE: Surgical Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the the Analgesic Efficacy and Tolerability of Meloxicam Versus Placebo and Ibuprofen in the Treatment of Pain After Surgery of the Third Molar
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Meloxicam 7.5 mg|DRUG: Meloxicam 3.75 mg|DRUG: Meloxicam 1.875 mg|DRUG: Ibuprofen 200 mg|DRUG: Placebo|DRUG: Meloxicam 15 mg|DRUG: Ibuprofen 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Benefits of the Use of the Feuerstein Cognitive Training Method on Cognitive Function in Community-dwelling Older Patients With Mild Cognitive Impairment: a Pilot Study
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: DEVICE: Feuerstein Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized, Double-blind, Placebo-controlled Trial of Curcumin in Leber's Hereditary Optic Neuropathy (LHON)
Status: COMPLETED
Conditions: Optic Atrophy, Hereditary, Leber
Interventions: DRUG: curcumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Biomarkers of Metabolic Liver Disease 1.1
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis|Nonalcoholic Fatty Liver
Interventions: DEVICE: Ultrasound based shear wave speed and fat quantification methods|DIAGNOSTIC_TEST: Blood collection|OTHER: Physical measurements|OTHER: Clinical history and medication reviews
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: SpyGlass in Post Liver Transplant Biliary Complications.
Status: COMPLETED
Conditions: Liver Transplant Disorder|Biliary Anastomosis Complication
Interventions: PROCEDURE: SpyGlass (direct visualization system) choledochoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of One Month Consumption of Standardized Aronia Melanocarpa Extract on Anemia in Patients on Hemodialysis
Status: TERMINATED
Conditions: Renal Disease|Dialysis; Complications|Anemia
Interventions: DIETARY_SUPPLEMENT: Alixir 400 Protect
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Immunogenicity of an Aluminium Hydroxide/LHD153R Adjuvanted Meningococcal C-CRM197 Conjugate Vaccine
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: Investigational MenC-CRM adjuavnted with 12.5 ug of LHD153R|BIOLOGICAL: Investigational MenC-CRM adjuavnted with 25 ug of LHD153R|BIOLOGICAL: Investigational MenC-CRM adjuavnted with 50 ug of LHD153R|BIOLOGICAL: Investigational MenC-CRM adjuavnted with 100 ug of LHD153R|BIOLOGICAL: Meningococcal C-CRM Conjugate Vaccine (MenC-CRM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study Investigating the Effects of Activamp on Body Weight, Fat Loss, and Metabolic Markers in Healthy Overweight Participants
Status: COMPLETED
Conditions: Body Weight
Interventions: DIETARY_SUPPLEMENT: Activamp|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Clinical Trial to Evaluate the Safety and Immunogenicity of a Single Dose of Adsorbed Tetanus Vaccine in a Population Aged 18 Years and Over
Status: RECRUITING
Conditions: Tetanus
Interventions: BIOLOGICAL: TTVA|BIOLOGICAL: TT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TRPV2 Agonists in the Fontan Circulation
Status: COMPLETED
Conditions: Fontan
Interventions: DRUG: Probenecid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Renal Resistive Index as a Marker of Severity and Treatment Outcomes in Lupus Nephritis
Status: UNKNOWN
Conditions: Lupus Nephritis
Interventions: DIAGNOSTIC_TEST: Doppler ultrasonography of renal arteries|DIAGNOSTIC_TEST: Renal biopsy|DIAGNOSTIC_TEST: kidney function tests|DIAGNOSTIC_TEST: The 24-hour urine protein test|DIAGNOSTIC_TEST: complete blood counting (CBC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Diffusion Tensor Imaging in Chronic Inflammatory Demyelinating Polyneuropathy (PIDC)
Status: COMPLETED
Conditions: CIDP (Chronic Inflammatory Demyelinating Polyradiculoneuropathy)|CMT (Charcot Marie Tooth Disease)
Interventions: DIAGNOSTIC_TEST: cervical MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Oncological Outcome of Contralateral Submental Artery Island Flap Versus Primary Closure in Tongue Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Tongue Squamous Cell Carcinoma
Interventions: PROCEDURE: contralateral submental flap for tongue cancer defect|PROCEDURE: primary closure for tongue cancer defect
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Vitamin D Supplementation During Pregnancy on Clinical Outcomes and Immune Function
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: 400 IU vitamin D3|DIETARY_SUPPLEMENT: 2,000 IU Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of a Coordinated Dietetic-adapted Physical Activity Program on the Percentage of Lean Body Mass in Adults With Cystic Fibrosis Treated With Elexacaftor-Tezacaftor-Ivacaftor: Multicentre Randomised Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Cystic Fibrosis
Interventions: OTHER: DIAPASOM program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Two Chlorhexidine Solutions to Control the Initial Subgingival Biofilm Formation
Status: COMPLETED
Conditions: Dental Plaque
Interventions: DRUG: 0.12% Clorhexidine with alcohol|DRUG: placebo|DRUG: 0.12% Clorhexidine without alcohol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: CSL H1N1 Influenza Vaccine Administered at Different Dose Levels With and Without AS03 Adjuvant in Healthy Adult and Elderly Populations
Status: WITHDRAWN
Conditions: Influenza
Interventions: BIOLOGICAL: AS03|BIOLOGICAL: Inactivated H1N1 Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Collection of Blood, Urine, and Stool to Monitor MetastaticColorectal Cancers
Status: COMPLETED
Conditions: Stage III Colorectal Cancer AJCC v8|Stage IIIA Colorectal Cancer AJCC v8|Stage IIIB Colorectal Cancer AJCC v8|Stage IIIC Colorectal Cancer AJCC v8|Stage IV Colorectal Cancer AJCC v8|Stage IVA Colorectal Cancer AJCC v8|Stage IVB Colorectal Cancer AJCC v8|Stage IVC Colorectal Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: FibroScan™ in Pediatric Cholestatic Liver Disease (FORCE)
Status: COMPLETED
Conditions: Biliary Atresia|Alagille Syndrome|Alpha1 Anti-Trypsin Deficiency|Portal Hypertension|Liver Fibrosis|Cholestasis
Interventions: OTHER: Liver Stiffness Measurement (LSM)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Eltrombopag for Post Transplant Thrombocytopenia
Status: COMPLETED
Conditions: Thrombocytopenia
Interventions: DRUG: Eltrombopag|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DCB Under the Guidance of OCT in STEMI
Status: RECRUITING
Conditions: Acute ST-segment Elevation Myocardial Infarction
Interventions: DEVICE: Drug-eluting balloon|DEVICE: Drug-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of FMT in Individuals With One or More Recurrences of Clostridium Difficile Associated Disease (CDAD)
Status: TERMINATED
Conditions: Clostridial Infection|Dysbiosis|Probiotic Therapy
Interventions: PROCEDURE: Fecal Microbiota Transplantation (FMT)|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study)
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome
Interventions: OTHER: Recruitment Maneuver (RM) sham group|OTHER: Sham recruitment maneuver (RM) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Telbivudine on Liver Cirrhosis in Patients With Chronic Hepatitis B (CHB)
Status: UNKNOWN
Conditions: Liver Cirrhosis|Chronic Hepatitis B
Interventions: DRUG: telbivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Preliminary Efficacy, Safety, and PK of Subcutaneous JS005 in Chinese Adult Patients With Active AS
Status: UNKNOWN
Conditions: Active Ankylosing Spondylitis
Interventions: BIOLOGICAL: JS005|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT