pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Chemotherapy Combined With Camrelizumab and Apatinib in First-line Treatment of ES-SCLC
Status: UNKNOWN
Conditions: Extensive Stage Small Cell Lung Cancer
Interventions: DRUG: Camrelizumab; apatinib; carboplatin; etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Nasal Influenza Immunisation in Egg Allergic Children - The SNIFFLE 2 Study
Status: COMPLETED
Conditions: Egg Hypersensitivity
Interventions: DRUG: Administration of Live attenuated influenza vaccine (LAIV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Topic Diclofenac as a Prevention of Postoperative Macular Edema in Patients With Diabetic Retinopathy
Status: COMPLETED
Conditions: Macular Edema|Cataract|Diabetic Retinopathy
Interventions: DRUG: Perioperative Diclofenac eye-drops administration|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A New Oral salIvary equivAlent Compared to Two moisturizinG Mouth sprAys in Patients With xeRostomiA: NIAGARA Study
Status: COMPLETED
Conditions: Xerostomia|Hyposalivation|Head and Neck Cancer|Sjögren Syndrome
Interventions: DEVICE: Salivary equivalent|DEVICE: Aequasyal|DEVICE: Biotene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Buspirone Therapy for Localized Epilepsy
Status: TERMINATED
Conditions: Anxiety Disorder|Seizures|Epilepsy|Partial Epilepsy|Depression
Interventions: DRUG: Buspirone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Role of Anthracycline After Radio Therapy in Patients With Glioblastoma (pGBM).
Status: RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: Radiotherapy, Temozolomide, Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of Insulin Compared to Glargine in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Human Insulin Inhalation Powder|DRUG: Insulin Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palatability of Oral Rehydration Solutions
Status: COMPLETED
Conditions: Gastroenteritis
Interventions: DRUG: Enfalyte|DRUG: Pediatric Electrolyte|DRUG: Pedialyte
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Dual-task Exercise in People With Cognitive Impairment
Status: ACTIVE_NOT_RECRUITING
Conditions: Dementia|Mild Cognitive Impairment|Older Adults
Interventions: OTHER: Dual-task exercise traning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Radiofrequency Versus Ethanol Injection for the Treatment of Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Carcinoma, Hepatocellular
Interventions: PROCEDURE: percutaneous ablation of hepatocellular carcinoma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antidepressive Effect on 5 Herz (Hz) rTMS Over Dorsomedial Prefrontal Cortex and Left Dorsolateral Prefrontal Cortex
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Radium-223 and Atezolizumab in Patients With Urothelial Carcinoma With Bone Metastases Who Have Had Disease Progression After Platinum-Based Chemotherapy
Status: TERMINATED
Conditions: Urothelial Carcinoma
Interventions: DRUG: Atezolizumab|DRUG: Radium-223
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation Of The Unilever Lifebuoy School-Based Handwashing Campaign (School Of 5) In Rural Bihar, India
Status: COMPLETED
Conditions: Diarrhea
Interventions: BEHAVIORAL: Lifebuoy School of Five Handwashing Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Extension Study to Evaluate the Long-Term Safety and Tolerability of Oral Atogepant for the Prevention of Migraine in Participants With Episodic Migraine
Status: COMPLETED
Conditions: Episodic Migraine
Interventions: DRUG: Atogepant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Efficacy of Steroid, Acupuncture and Platelet Rich Plasma Injection in Patients With Sciatica
Status: RECRUITING
Conditions: Sciatica
Interventions: OTHER: Steroid|OTHER: Acupuncture|OTHER: Platelet Rich Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Sodium Oligomannate (GV-971) in Participants With Mild to Moderate Alzheimer's Disease
Status: SUSPENDED
Conditions: Alzheimer Disease
Interventions: DRUG: GV-971|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of a Novel Balance, Vestibular and Oculomotor Assessment Tool
Status: COMPLETED
Conditions: Mild Concussion|Post Concussion Syndrome|Vestibular Neuritis
Interventions: DEVICE: iDETECT Assessment|BEHAVIORAL: Routine Balance and Vestibular Testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of LixiLan Versus Insulin Glargine Alone Both With Metformin in Japanese With Type 2 Diabetes Mellitus Inadequately Controlled on Basal Insulin and Oral Antidiabetic Drugs
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Insulin glargine/Lixisenatide (HOE901/AVE0010)|DRUG: Insulin glargine U100 (HOE901)|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Genotype on CYP2C9 Drug Interactions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Flurbiprofen Control - Flurbiprofen Only|DRUG: Flurbiprofen Inhibition - Flurbiprofen & Fluconazole|DRUG: Ketoprofen Control - Ketoprofen Only|DRUG: Ketoprofen Inhibition - Ketoprofen & Fluconazole|DRUG: Tolbutamide Control - Tolbutamide Only|DRUG: Tolbutamide Inhibition - Tolbutamide & Fluconazole
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 1 Study of Oprozomib to Assess Food Effect, Drug-Drug Interaction With Midazolam, and Safety and Tolerability in Patients With Advanced Malignancies
Status: TERMINATED
Conditions: Advanced Non-Central Nervous System (CNS) Malignancies
Interventions: DRUG: Oprozomib|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Bioequivalence of Palonosetron (0.25mg/5mL)
Status: COMPLETED
Conditions: Chemotherapy-induced Nausea and Vomiting, Prophylaxis
Interventions: DRUG: Palonosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Folate on Colon and Blood Cells
Status: COMPLETED
Conditions: Subjects Will Have a Pre-cancerous Colorectal Polyp|Family Member Has History of Colorectal Adenoma of Adenocarcinoma
Interventions: PROCEDURE: Folate depletion and supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: Analysis of SARS-CoV2 Urine Viral Particles and Association With Proximal Tubular Dysfunction
Status: UNKNOWN
Conditions: SARS-CoV2 Infection|Proximal Tubule Dysfunction
Interventions: OTHER: RT-PCR SARS-COV2 in urine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Development of a Multi-sensory Rehabilitation Program for People With Ultra Low Vision
Status: RECRUITING
Conditions: Low Vision Blindness|Visual Impairment|Quality of Life|Functional Visual Loss
Interventions: BEHAVIORAL: Visual Information Training|BEHAVIORAL: Multimodal training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid in the Treatment of Residual Chronic Subdural Hematoma
Status: UNKNOWN
Conditions: Chronic Subdural Hematoma
Interventions: DRUG: Tranexamic Acid 500 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 52-week International, Multicenter Trial With a Long -Term Extension to Evaluate Saxagliptin With Dapagliflozin in Combination With Metformin Compared to Glimepiride in Combination With Metformin in Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin Alone
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: Saxagliptin|DRUG: Dapagliflozin|DRUG: Glimepiride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Physiotherapy Treatment for Patients Suffering From Head and Neck Cancer
Status: COMPLETED
Conditions: Oral Cavity Carcinoma|Oropharyngeal Cancer|Adverse Effect of Radiation Therapy|Trismus
Interventions: OTHER: physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Early Active Controlled Motion (EACM) Rehabilitation Protocol Post Open Reduction and Internal Fixation (ORIF) of Scaphoid Fractures: A Pilot Study
Status: WITHDRAWN
Conditions: Scaphoid Fixation
Interventions: OTHER: Early Active Controlled Motion (EACM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iliac Vein Stenting in Advanced Chronic Venous Insufficiency
Status: COMPLETED
Conditions: Iliac Vein Obstruction|May-Thurner Syndrome|Cockett Syndrome
Interventions: DRUG: Phlebotonic|DEVICE: Stent|PROCEDURE: Limb elastic compression support|PROCEDURE: Unna boot dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy of Ivacaftor in Subjects With Cystic Fibrosis Who Have a 3849 + 10KB C→T or D1152H CFTR Mutation
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Ivacaftor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypotension Prediction Index Based Perioperative Protocolized Hemodynamic Management in Geriatric Orthopedic Surgery
Status: UNKNOWN
Conditions: Orthopedic Disorder|Hemodynamic Instability
Interventions: OTHER: hypotension prediction index(HPI)|OTHER: ordinary goal-directed hemodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Efficacy and Safety of Dapagliflozin as Monotherapy in Subjects With Type 2 Diabetes Who Have Inadequate Glycaemic Control With Diet and Exercise Alone
Status: SUSPENDED
Conditions: Type 2 Diabetes
Interventions: DRUG: Dapagliflozin|DRUG: Dapagliflozin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Low and High Ligation in the Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: PROCEDURE: preservation of nerve fibers around IMA|PROCEDURE: resection of nerve fibers around IMA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab + High-Dose Methylprednisolone Debulking Prior to Venetoclax for CLL & SLL Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Interventions: DRUG: HDMP + rituximab as a means of debulking prior to initiating venetoclax.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Meat Derivative and Satiating Compound Effect on Satiety
Status: COMPLETED
Conditions: Overweight
Interventions: OTHER: Placebo meat derivative + Placebo satiating compound|OTHER: Placebo meat derivative + Satiating compound|OTHER: Experimental meat derivative + Placebo satiating control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: IN Ketamine vs IN Midazolam and Fentanyl for Laceration Repair
Status: TERMINATED
Conditions: Laceration of Skin
Interventions: DRUG: Ketamine|DRUG: Midazolam and fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Mind/Body Health and Functioning With Integrative Exercise
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic
Interventions: OTHER: Veterans Group Exercise (VGX)|OTHER: Illness Management and Recovery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect on Vascular Reactivity Using the Erythropoeitin Alpha on Incident Peritoneal Dialysis Patients
Status: COMPLETED
Conditions: Chronic Kidney Disease|Anemia|Complication of Peritoneal Dialysis
Interventions: DRUG: Renogen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects Of Upper Extremity Robotic Rehabilitation On Upper Extremity Functions And Gait Parameters
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: conventional physiothrapy|OTHER: robotic rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Controlled Study of Stage 3 Osteonecrosis Treatment by Bone Marrow
Status: COMPLETED
Conditions: Non Traumatic Osteonecrosis of the Femoral Head (Hip)
Interventions: PROCEDURE: core decompression with autologous bone marrow implantation|PROCEDURE: core decompression of the femoral head
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Study of Lisdexamfetamine in Healthy and Hypertensive Attention Deficit Hyperactivity Disorder Adults
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: DRUG: Lisdexamfetamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Comparative Split-Face Study of the Effects of a Retinol Alternative Cream on Improving Facial Skin Aging
Status: COMPLETED
Conditions: Skin Aging
Interventions: OTHER: Dime Beauty TBT Cream|OTHER: Positive Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Self-Gated Breath-Hold Technique for Helical Tomotherapy in Patients With Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: PROCEDURE: Tomotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib and Carboplatin in Treating Patients With Recurrent or Progressive Ovarian Epithelial, Primary Peritoneal, or Fallopian Tube Cancer
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: bortezomib|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Positive End Expiratory Pressure (PEEP) on Cerebral Oxymetry During Laparoscopy
Status: COMPLETED
Conditions: Cerebral Ischemia
Interventions: PROCEDURE: zero end-expiratory pressure|PROCEDURE: positive end expiratory pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Dexamethasone and Etoricoxib for Pain Prevention Following Periodontal Surgery
Status: COMPLETED
Conditions: Pain Control
Interventions: PROCEDURE: Open Flap Debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glu-COACH: a Peer-mentoring Intervention to Reduce Disparities in Continuous Glucose Monitor (CGM) Use
Status: RECRUITING
Conditions: Type 1 Diabetes
Interventions: BEHAVIORAL: Glu-COACH|BEHAVIORAL: Enhanced standard-of-care (ESOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of PF614 Compared to OxyContin® in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF614|DRUG: Oxycodone extended-release|DRUG: Naltrexone Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study With Upadacitinib (ABT-494) in Subjects From China and Selected Countries With Moderately to Severely Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs)
Status: COMPLETED
Conditions: Rheumatoid Arthritis (RA)
Interventions: DRUG: Upadacitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate CSJ148 in Pregnant Women With Primary HCMV Infection
Status: WITHDRAWN
Conditions: HCMV Infection
Interventions: BIOLOGICAL: CSJ148|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neurocognitive Performance and Emotional State in HCV Patients With IFN-free Antiviral Therapy
Status: UNKNOWN
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Combination #1|DRUG: Combination #2|DRUG: Combination #3|DRUG: Combination #4|DRUG: Combination #5
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Double-blind Study to Evaluate the Safety of Glutamic Acid Decarboxylase Gene Transfer in Parkinson's Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson Disease
Interventions: GENETIC: AAV-GAD Dose 1|GENETIC: AAV-GAD Dose 2|PROCEDURE: Sham Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging With 11C-erlotinib PET/CT to Identify Responders to Erlotinib Treatment in NSCLC
Status: TERMINATED
Conditions: Lung Cancer
Interventions: OTHER: 11C-erlotinib PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pharmacodynamic Study of the Apheresis Product of Multiple Myeloma Patients Undergoing Quad-induction Followed by Motixafortide + G-CSF Mobilization
Status: NOT_YET_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Motixafortide|DRUG: G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of of a Prefixed 50% N2O- 50%O2 Mixture in Legal Abortion Under Local Analgesia
Status: COMPLETED
Conditions: Abortion
Interventions: DRUG: 50% N2O- 50%O2 mixture|DRUG: Placebo (air)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Examining the Effects of a Mobilization With Movement and a Dynamic Stretch With Over Pressure on Hip Flexion.
Status: COMPLETED
Conditions: Hip; Anomaly
Interventions: PROCEDURE: Mobilization with movement and stretching, stretching or control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics to Enhance Immunogenicity of Influenza Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Lactobacillus rhamnosus|DIETARY_SUPPLEMENT: placebo control|BIOLOGICAL: Influenza Virus Vaccine Live, Intranasal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Accelerated Hypofractionated Radiotherapy (AHF-RT) for the Treatment of Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: RADIATION: accelerated hypofractionated radiotherapy (AHF-RT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Response Adapted Ultra Low Dose 4 Gy Radiation for Definitive Therapy of Marginal Zone Lymphoma
Status: RECRUITING
Conditions: Lymphoma
Interventions: RADIATION: Ultra Low Dose 4 Gy Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selenium Supplementation of Patients With Cirrhosis
Status: TERMINATED
Conditions: Cirrhosis
Interventions: DIETARY_SUPPLEMENT: selenium|DIETARY_SUPPLEMENT: selenium|DIETARY_SUPPLEMENT: selenium|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase Ⅱ Clinical Study of R435 (Bevacizumab) in Combination With Paclitaxel in Patients With Inoperable Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: bevacizumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Accuracy of Landmarks for Neuraxial Blocks in Pregnancy: The Sacral Anatomical Interspace Landmark (SAIL) Technique
Status: COMPLETED
Conditions: Pregnancy Related
Interventions: OTHER: Classic Intercristal Line Technique|OTHER: Novel SAIL Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Economic Evaluation of New MDR TB Regimens
Status: COMPLETED
Conditions: Multi-drug Resistant Tuberculosis|Extensively Drug-Resistant Tuberculosis|Pulmonary Tuberculoses
Interventions: DRUG: Bedaquiline|DRUG: Pretomanid|DRUG: Moxifloxacin|DRUG: Linezolid|DRUG: Clofazimine|DRUG: Standard Drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Antiviral Therapy in Pregnant Women to Reduce Mother-to-infant Transmission of Hepatitis B Virus-drug Test
Status: UNKNOWN
Conditions: Hepatitis B Virus Infection, Pregnancy
Interventions: DRUG: antiviral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation in Conjunction With Individualized Physical Therapy for Individuals With Chronic Knee Pain
Status: NOT_YET_RECRUITING
Conditions: Knee Pain Chronic
Interventions: DEVICE: transcranial direct current stimulation|OTHER: physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of HU00701/HU007 Eye Drops in Patients With Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: HU00701|DRUG: HU007|DRUG: Restasis|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Vaccinium Myrtillus L. Extract Intake on Human Metabolism
Status: UNKNOWN
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Vaccinium Myrtillus L. extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of OMT on the Expression Patterns of Immune Cell Biomarkers
Status: TERMINATED
Conditions: Osteopathic Manipulation|Low Back Pain|Biomarkers
Interventions: OTHER: The Osteopathic Manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase I & Biological Study of Etanercept & Weekly Docetaxel in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Tumors
Interventions: DRUG: Etanercept|DRUG: Docetaxel|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oscillating Positive Expiratory Pressure (OPEP) Therapy in Trauma Patients With Multiple Rib Fractures
Status: RECRUITING
Conditions: Rib Fractures|Respiratory Complication
Interventions: DEVICE: Oscillating Positive Expiratory Pressure Device|DEVICE: Incentive spirometry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: NGR-hTNF Administered in Combination With a Standard Oxaliplatin Based Regimen in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colon Cancer
Interventions: DRUG: NGR-hTNF|DRUG: Oxaliplatin|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Screening for Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD) at Al-Rajhy Hospital Nutrition Clinic. Assiut, Egypt
Status: UNKNOWN
Conditions: Steatohepatitis, Nonalcoholic
Interventions: DEVICE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: 68Ga-FAPI-46 PET/CT for Predicting Histological Response in Triple-negative Breast Cancer (FAP-IT)
Status: NOT_YET_RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: PROCEDURE: 68Ga-FAPI-46 PET/CT imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate Antimalarial Activity and Safety of MK-7602 in Healthy Adults (MK-7602-003)
Status: RECRUITING
Conditions: Malaria
Interventions: OTHER: Plasmodium falciparum|DRUG: MK-7602|DRUG: Artemether/lumefantrine|DRUG: Primaquine|DRUG: Artesunate|DRUG: Atovaquone/proguanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vivifi's Treatment, BPH Treatment Via Vasculature Anastomosis
Status: NOT_YET_RECRUITING
Conditions: Benign Prostatic Hyperplasia|Varicocele Grade II|Varicocele Grade III
Interventions: PROCEDURE: Vivifi's Surgical Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Fluticasone/Formoterol Breath Actuated Inhaler (BAI) or Relvar® Ellipta® DPI on Ventilation Heterogeneity in Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone/Formoterol BAI|DRUG: Fluticasone/Vilanterol DPI (Relvar Ellipta DPI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Effect of Ventilatory Support During Exercise in Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: DEVICE: Non-invasive ventilation(NIV)|DEVICE: Sham Non-invasive ventilation(NIV)|OTHER: Functional Electrical Stimulation Row Training (FESRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Evidence Based Smoking Cessation Program for Persons Living With HIV/AIDS (Project Legacy)
Status: WITHDRAWN
Conditions: Tobacco Use Cessation
Interventions: DRUG: Nicotine Patch|BEHAVIORAL: Phone Counseling|BEHAVIORAL: Questionnaires|BEHAVIORAL: Breath Test|BEHAVIORAL: Proactive Cell Phone Smoking Cessation Counseling|BEHAVIORAL: Text Message Smoking Cessation Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Outcome of Transarterial Chemo-embolization (TACE) in Hepatocellular Carcinoma Patients With Partial Portal Vein Thrombosis
Status: COMPLETED
Conditions: Hepatocellular Carcinoma (HCC)
Interventions: PROCEDURE: transarterial chemoembolization versus the standard treatment with sorafinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of White Kidney Bean on Oral Glucose Tolerance Test
Status: COMPLETED
Conditions: Diabetes|Sugar; Blood, High
Interventions: DIETARY_SUPPLEMENT: Phase 1 Wonderlab Product|DIETARY_SUPPLEMENT: Phase 1 Placebo|DIETARY_SUPPLEMENT: Phase 2 Placebo|DIETARY_SUPPLEMENT: Phase 2 Wonderlab Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Oral Zinc Gluconate Among Acne Vulgaris Patients
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DIETARY_SUPPLEMENT: Zinc gluconate|DRUG: Adapalene 0.003 MG/MG / Benzoyl Peroxide 0.025 MG/MG Topical Gel [Epiduo]|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous vs. Oral Hydration to Reduce the Risk of Post-Contrast Acute Kidney Injury After Intravenous Contrast-Enhanced Computed Tomography in Patients With Severe Chronic Kidney Disease
Status: RECRUITING
Conditions: Contrast-induced Nephropathy|Kidney Injury|Kidney Failure, Chronic|Risk Reduction
Interventions: OTHER: Preventive treatment with IV-hydration|OTHER: Preventive treatment with oral hydration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CBD Effects on Periodontal Health of Patients With Chronic Periodontitis
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: COMBINATION_PRODUCT: placebo dental gel, placebo toothpaste|COMBINATION_PRODUCT: Cannabidiol dental gel, Cannabidiol toothpaste|COMBINATION_PRODUCT: Placebo toothpaste, Corsodyl dental gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Tolerability, Safety and Pharmacokinetic Characteristics of DA-3803
Status: COMPLETED
Conditions: Infertility|Induction of Ovulation
Interventions: DRUG: T-R (Test-Reference drug)|DRUG: R-T (Reference-Test drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Assess the Pharmacokinetics of Intravenous Nabi 5% Hepatitis B Immune Globulin (Boca HBVIg) Used in Combination With Lamivudine for Patients With Hepatitis B Virus (HBV) Associated Liver Disease Undergoing Liver Transplantation
Status: COMPLETED
Conditions: Hepatitis B Virus Associated Liver Disease
Interventions: BIOLOGICAL: Hepatitis B Immune Globulin (Boca HBVIg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Characterize the Long-term Clinical Experience of Atacand in Hypertensive Children Ages 1 to<11 Years (Hypertension in Pediatrics)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: candesartan cilexetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-interventional Study With Ra-223 Dichloride Assessing Overall Survival and Effectiveness Predictors for mCRPC Patients in a Real Life Setting in Germany
Status: COMPLETED
Conditions: Prostatic Neoplasms, Castration-Resistant
Interventions: DRUG: Radium-223-dichloride (Xofigo, BAY88-8223)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Taurine Supplementation and Exercise on Irisin Levels in Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Taurine group and exercise and placebo group and exercise|OTHER: Physical training with Deep Water Running
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Fast-track Surgery After Gynecological Oncology Surgery
Status: COMPLETED
Conditions: Length of Stay|Postoperative Complications|CRP
Interventions: PROCEDURE: pre-operative assessment, counseling and education|PROCEDURE: Preoperative nutritional drink up to 4 h prior to surgery|PROCEDURE: bowel preparation|PROCEDURE: preoperative treatment with carbohydrates|PROCEDURE: fast solid|PROCEDURE: avoiding hypothermia|PROCEDURE: Postoperative glycaemic control|PROCEDURE: postoperative nausea and vomiting (PONV) control;|PROCEDURE: early postoperative diet|PROCEDURE: pre-operative fasting at least 8h|PROCEDURE: bowel preparation for traditional surgery|PROCEDURE: began to take solid diet after anal exhaust
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Almased Multi-Center Diabetes Intervention Trial
Status: COMPLETED
Conditions: Type 2 Diabetes|Obesity
Interventions: DIETARY_SUPPLEMENT: Almased Meal Replacement Powder|BEHAVIORAL: Group-Based Lifestyle Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Oral Health Status in Patients With Cirrhosis and Effect of Dental Treatment on MELD Score of Cirrhosis Patients
Status: UNKNOWN
Conditions: Liver Cirrhosis|Periapical Lesions
Interventions: PROCEDURE: Nonsurgical root canal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Limaprost in Combination With Transforaminal Epidural Steroid Injection
Status: RECRUITING
Conditions: Lumbar Spinal Stenosis
Interventions: PROCEDURE: Transforaminal epidural steroid injection (TFESI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate in Combination With Docetaxel for Advanced, Platinum-Refractory Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Imatinib Mesylate|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of the Glycemic Index and the Insulinemic Index of a Sweetener Syrup
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: Experimental sweetener syrup|OTHER: Classical sweetener syrup|OTHER: Classical sugar syrup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 2 Study on Effects of Obeticholic Acid (OCA) on Lipoprotein Metabolism in Participants With Primary Biliary Cirrhosis
Status: COMPLETED
Conditions: Primary Biliary Cirrhosis
Interventions: DRUG: Obeticholic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Administering FOLFIRINOX Before Surgery For Potentially Curable Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: DRUG: Oxaliplatin|DRUG: Irinotecan|DRUG: Leucovorin|DRUG: Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prochymal™ Adult Human Mesenchymal Stem Cells for Treatment of Moderate-to-severe Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: Prochymal™ adult human mesenchymal stem cells|DRUG: adult human mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Results of Opening-wedge High Tibial Osteotomy Using Iliac Crest Allograft Compared to Iliac Crest Autograft
Status: COMPLETED
Conditions: Genovarum
Interventions: PROCEDURE: Iliac crest allograft|PROCEDURE: Iliac crest autograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Clinical Trial of Concurrent Chemoradiotherapy Combined Nimotuzumab for Stage IIB-IVA Cervical Cancer
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: DRUG: Cisplatin|RADIATION: External Beam Radiation Therapy|RADIATION: Internal Radiation Therapy|DRUG: nimotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Emails and Personalized Phone Calls to Increase Affordable Care Act Marketplace Enrollment Among Households Losing Medicaid
Status: COMPLETED
Conditions: Health Behavior
Interventions: BEHAVIORAL: Control group|BEHAVIORAL: Email only|BEHAVIORAL: Phone only|BEHAVIORAL: Phone and email
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Overactive Bladder Treatment Using StimRouter Neuromodulation System: A Prospective Randomized Trial
Status: UNKNOWN
Conditions: Overactive Bladder
Interventions: DEVICE: StimRouter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Randomized Controlled Study of 3D Laparoscopy Versus Endoscopy in the Treatment of Choledocholithiasis
Status: UNKNOWN
Conditions: Choledocholithiasis|ERCP
Interventions: PROCEDURE: 3D LCBDE|PROCEDURE: ERCP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Imaging the Effects of Bihemispheric Transcranial Stimulation and Motor Training After Stroke.
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: tDCS + upper limb rehabilitation|DEVICE: Sham tDCS + upper limb rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Talimogene Laherparepvec for the Treatment of Peritoneal Surface Malignancies
Status: COMPLETED
Conditions: Stage IV Peritoneal Surface Dissemination From Gastrointestinal or Recurrent, Platinum-resistant Ovarian Cancer That Cannot be Completely Resected
Interventions: BIOLOGICAL: Talimogene Laherparepvec
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Prophylactic High Flow Nasal Oxygen in Post-Operative Thoracic Surgical Patients
Status: COMPLETED
Conditions: Post-operative Pulmonary Complications
Interventions: DEVICE: Heated humified high-flow nasal cannula Oxygen|OTHER: Standard oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Multimodal Neuroimaging Analysis After Mild Traumatic Brain Injury
Status: TERMINATED
Conditions: Mild Traumatic Brain Injury
Interventions: PROCEDURE: Brain Magnetic Resonance Imaging (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Counterpulsation Reduces Infarct Size Pre-PCI for AMI
Status: COMPLETED
Conditions: Acute Myocardial Infarction (AMI)
Interventions: DEVICE: Counterpulsation with IAB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanistic Study of the Effect of Itepekimab on Airway Inflammation in Patients With COPD
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Itepekimab SAR440340
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Study of Continuation Treatment With Combination Pyrimidine Nucleosides in Patients With TK2 Deficiency
Status: ACTIVE_NOT_RECRUITING
Conditions: Thymidine Kinase 2 Deficiency
Interventions: DRUG: doxecitine and doxribtimine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing a CBT Program for Anxiety in Teenagers With Autism: A Feasibility Study
Status: COMPLETED
Conditions: Anxiety|Autism
Interventions: BEHAVIORAL: Cool Kids (Chilled) Anxiety program adapted to children and youths with autism and anxiety disorders.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Delivery Timing in Morbidly Adherent Placentas: a Randomized, Controlled Trial
Status: WITHDRAWN
Conditions: Morbidly Adherent Placenta|Placenta Accreta
Interventions: OTHER: Scheduled timing of delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Web-based ACT to Support Parents With Children With Chronic and Developmental Conditions
Status: COMPLETED
Conditions: Burnout Syndrome|Psychological Distress|Depressive Symptoms|Quality of Life
Interventions: BEHAVIORAL: Internet-based ACT intervention|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Tub vs Sponge Bathing on the Comfort of Premature Infants
Status: COMPLETED
Conditions: Preterm Infant|Premature Birth
Interventions: BEHAVIORAL: Tub Bathing|BEHAVIORAL: Sponge Bathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: AT GOAL: Adopting Technology for Glucose Optimization and Lifestyle in Pregnancy
Status: ACTIVE_NOT_RECRUITING
Conditions: Type2Diabetes|Pregnancy in Diabetic
Interventions: DEVICE: Dexcom G6 CGM|OTHER: Participant Finger Stick Glucose Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Autologous Platelet-rich Plasma (PRP) and Thrombin Coagulum for the Topical Treatment of Rectal Mucosal Ulcers
Status: NOT_YET_RECRUITING
Conditions: Ulcerative Colitis Chronic Moderate|Ulcerative Colitis Chronic Severe|Rectal Ulcer
Interventions: OTHER: Autologous Platelet-rich Plasma (PRP) and Thrombin Coagulum Treatment|OTHER: Autologous Platelet-poor Plasma (PPP) and Thrombin Coagulum Treatment|DRUG: Mesalazine Suppository Treatment|BIOLOGICAL: Infliximab Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Food Response Training for Binge Eating
Status: TERMINATED
Conditions: Binge Eating
Interventions: BEHAVIORAL: Go/No-Training|BEHAVIORAL: Stop-Signal Training|BEHAVIORAL: Dot-Probe Paradigm|BEHAVIORAL: Generic Response Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase IV, Randomized, Parallel Group, Investigator-Masked Evaluation of the Effect of Loteprednol Etabonate Ophthalmic Gel 0.5% on the Initiation of Dry Eye Treatment With Restasis®
Status: WITHDRAWN
Conditions: Dry Eye Disease
Interventions: DRUG: Loteprednol etabonate|DRUG: Artificial Tears|DRUG: Restasis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT