pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Brain Responses to Short-Chain Fatty Acid Intervention
Status: NOT_YET_RECRUITING
Conditions: Stress|Healthy Volunteers
Interventions: OTHER: Short-Chain Fatty Acids|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Monitored Anesthesia Care With Propofol Plus Remifentanil During Endoscopic Submucosal Dissection: Evaluation of Bispectral Index Monitoring
Status: COMPLETED
Conditions: Early Gastric Cancer
Interventions: DEVICE: BIS sensor attachment|DRUG: no- BIS sensor attachment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.
Status: ACTIVE_NOT_RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: Psilocybin (0.25mg/kg)|DRUG: Niacin (250mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quadratus Lumborum Block Versus Control for Total Hip Arthroplasty
Status: COMPLETED
Conditions: Total Hip Arthroplasty
Interventions: DRUG: Quadratus Lumborum Block (QLB)|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Vibration and Standing Versus Standing Alone for the Treatment of Osteoporosis for People With Spinal Cord Injury.
Status: COMPLETED
Conditions: Spinal Cord Injury.|Osteoporosis.
Interventions: DEVICE: vibration and passive standing versus passive standing alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Ethnicity and ABCB1 Gene Polymorphism on the Pharmacokinetics of Azithromycin in Healthy Bangladeshi Volunteers
Status: UNKNOWN
Conditions: Comparative Bioavailability Study
Interventions: DRUG: Azithromycin Dihydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Placebo and Active Controlled, Double Dummy Study to Compare Efficacy of Aspirin and Ibuprofen in Treatment of Episodic Tension-type Headache
Status: COMPLETED
Conditions: Headache|Tension-Type Headache|Tension-Type Headache (Episodic)
Interventions: DRUG: Acetylsalicylic acid (Aspirin, BAYE4465)|DRUG: Acetylsalicylic acid (Aspirin, BAYE4465)|DRUG: Ibuprofen|DRUG: Ibuprofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Study of an Investigational Drug, Revusiran (ALN-TTRSC), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis in Patients Whose Disease Has Continued to Worsen Following Liver Transplant
Status: COMPLETED
Conditions: Transthyretin (TTR)-Mediated Amyloidosis|Familial Amyloidotic Polyneuropathy (FAP)|ATTR Amyloidosis|Familial Amyloid Neuropathies
Interventions: DRUG: Revusiran
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interaction Between Host, Microenvironment and Immunity on Gastrointestinal Neoplasms
Status: RECRUITING
Conditions: Gastrointestinal Neoplasms
Interventions: BIOLOGICAL: Blood sampling|PROCEDURE: Liver biopsy|BIOLOGICAL: Stool collect
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Efficacy of Thread Embedding Acupuncture on Pain Score, Neck Disability Index, and Pressure Pain Threshold for Myofascial Pain Therapy in the Upper Trapezius Muscle
Status: COMPLETED
Conditions: Myofascial Pain of Upper Trapezius Muscle
Interventions: PROCEDURE: Thread-Embedding Acupuncture, Sham Thread-Embedding Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Whey Protein Supplementation Collagen Associated to Resistance Training in Older Woman
Status: COMPLETED
Conditions: Sarcopenia|Collagen Degeneration
Interventions: DIETARY_SUPPLEMENT: Whey protein plus collagen|DIETARY_SUPPLEMENT: Whey protein plus maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: QL1706 Plus Chemotherapy±Bevacizumab for the First-Line Treatment of Persistent, Recurrent or Metastatic Cervical Cancer
Status: RECRUITING
Conditions: METASTATIC CERVICAL CANCER
Interventions: DRUG: QL1706|DRUG: Placebo|DRUG: Paclitaxel injection|DRUG: Cisplatin/Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of KGR Prescriptions in Suppressing COVID-19 Infection.
Status: COMPLETED
Conditions: Coronavirus Disease 2019|Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Interventions: COMBINATION_PRODUCT: Kang Guan Recipe (Treat)|COMBINATION_PRODUCT: Kang Guan Recipe (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Comparison of Oxytocin Induced Labor and Cook Balloon Induced Labor
Status: UNKNOWN
Conditions: Labor; Forced or Induced, Affecting Fetus or Newborn
Interventions: OTHER: Cook Balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Study of a Recombinant Staphylococcus Aureus Vaccine (Escherichia Coli) in Healthy Adults
Status: COMPLETED
Conditions: Staphylococcus Aureus Infection
Interventions: BIOLOGICAL: Staphylococcus aureus vaccine (60µg/per protein)|BIOLOGICAL: Staphylococcus aureus vaccine (30µg/per protein)|BIOLOGICAL: Staphylococcus aureus vaccine (15µg/per protein)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Extension Study to Evaluate Long-Term Effects of Luspatercept in Patients With Myelodysplastic Syndromes (MDS) (A536-05/MK-6143-003)
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Luspatercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of 3 Dosage Strengths of Almotriptan Malate (AXERT®) in the Treatment of Acute Migraine in Adolescents
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: almotriptan malate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin C on Pain Reduction After an Emergency Department Visit
Status: NOT_YET_RECRUITING
Conditions: Pain, Acute
Interventions: DIETARY_SUPPLEMENT: Acetaminophen and Vitamin C with Naproxen rescue|OTHER: Acetaminophen and Placebo with Naproxen rescue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Daptomycin as Adjunctive Therapy for Staphylococcus Aureus Bacteremia
Status: COMPLETED
Conditions: Methicillin Susceptible Staphylococcus Aureus Septicemia|Bacteremia
Interventions: DRUG: Daptomycin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First-in-Human Study of EOS100850 in Patients With Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor, Adult
Interventions: DRUG: EOS100850|DRUG: Pembrolizumab|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Efficacy and Safety Intravenous Benapenem in Patients With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)
Status: COMPLETED
Conditions: Complicated Urinary Tract Infection Including Acute Pyelonephritis
Interventions: DRUG: Benapenem|DRUG: Ertapenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed Plus Gemcitabine or Carboplatin for Patients With Advanced Malignant Pleural Mesothelioma
Status: COMPLETED
Conditions: Mesothelioma
Interventions: DRUG: pemetrexed disodium|DRUG: gemcitabine hydrochloride|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Transforaminal Epidural Steroid Injection in Lumbar Disc Prolpse on Micro RNA-155 Serum Level
Status: COMPLETED
Conditions: Lumbar Disc Herniation
Interventions: DRUG: transforaminal epidural injection.|OTHER: micro RNA-155 serum level
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Analgesic Efficacy of Ultrasound Guided Transversus Abdominal Plane Block After Abdominal Cancer Surgeries
Status: COMPLETED
Conditions: Abdominal Cancer
Interventions: DRUG: Bupivacaine (Transversus Abdominis Plane Block)|DRUG: Intravenous Patient Controlled Analgesia (PCA) Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Trastuzumab Emtansine in Combination With Atezolizumab or Atezolizumab-Placebo in Participants With Human Epidermal Growth Factor-2 (HER2) Positive Locally Advanced or Metastatic Breast Cancer (BC) Who Received Prior Trastuzumab and Taxane Based Therapy
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Atezolizumab|DRUG: Trastuzumab emtansine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of Radiotherapy Combined With Ripretinib in the Treatment of Unresectable Advanced GIST
Status: RECRUITING
Conditions: Gastrointestinal Stromal Tumors
Interventions: RADIATION: simultaneous integrated boost intensity-modulated radiation therapy combined with ripretinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Feasibility Study of an Intracortical Visual Prosthesis (ICVP) for People With Blindness
Status: UNKNOWN
Conditions: Ocular Injury|Optic Nerve Diseases|Photoreceptor Degeneration|Blindness,Acquired
Interventions: DEVICE: WFMA - wireless floating microelectrode array
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: ArtontheBrain: An Inclusive Evidence-based Cognitive Health App for Older Adults to Promote Aging at Home
Status: UNKNOWN
Conditions: Cognitive Impairment|Mild Cognitive Impairment|Dementia|Age-related Cognitive Decline|Aging
Interventions: DEVICE: ArtontheBrain|DEVICE: Seniors Online Victoria
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Profile and Anthropometric Changes in Schizophrenia
Status: COMPLETED
Conditions: Metabolic Syndrome|Diabetes|Obesity
Interventions: DRUG: Olanzapine|DRUG: Risperidone|DRUG: Haloperidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Trial of Gemcitabine With or Without MSC1936369B in Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma
Interventions: DRUG: Pimasertib|DRUG: Gemcitabine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Biological Responses to Low Level Ozone
Status: COMPLETED
Conditions: Environmental Exposure|Nasal Inflammation
Interventions: OTHER: Ozone|OTHER: Filtered Air|DEVICE: Health and Exposure Tracker (HET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Treatment of Stage I and II Carcinoma of the Breast With Mastectomy and Axillary Dissection Versus Excisional Biopsy, Axillary Dissection, and Definitive Irradiation
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: M|RADIATION: X
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Human Tick Kill Study to Investigate the Safety, Tolerability, and Whole Blood Concentration of TP-05
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Volunteer
Interventions: DRUG: Low Dose TP-05|DRUG: High Dose TP-05|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Duodenal Mucosal Resurfacing (DMR) Using the Revita System in the Treatment of Type 2 Diabetes (T2D)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Noninsulin-Dependent Diabetes Mellitus
Interventions: PROCEDURE: DMR Procedure|PROCEDURE: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Camrelizumab for Injection, Apatinib Mesylate and Tegio for First-line Refractory Patients With Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: Camrelizumab for injection, apatinib mesylate and tegio
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safe Use of CPAP and PEEP During Induction of General Anesthesia
Status: COMPLETED
Conditions: General Anesthesia
Interventions: PROCEDURE: Pressure controlled ventilation with PEEP|PROCEDURE: Manual ventilation without PEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Laparoscopic Preperitoneal Local Anesthetic Infiltration Versus Ultrasound Guided Quadratus Lumborum Block in Laparoscopic Bariatric Surgery
Status: RECRUITING
Conditions: Pain Management
Interventions: PROCEDURE: preperitoneal local anesthetic infiltration in group p , quadratus lamborum block in group Q
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Fluorescence Imaging of Carcinoma During Breast Conserving Surgery
Status: RECRUITING
Conditions: Breast Neoplasm Female|Breast Cancer
Interventions: DRUG: Aminolevulinic Acid Hydrochloride|DEVICE: Eagle V1.2 Imaging System|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimized Intensity Modulated Irradiation for Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: RADIATION: IMRT|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketone for Migraine Prevention
Status: COMPLETED
Conditions: Migraine Headache
Interventions: DIETARY_SUPPLEMENT: Nutritional Ketogenic Supplement|DIETARY_SUPPLEMENT: Isocaloric placebo supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Learn More About the Onset of Effect of Iberogast in Patients Suffering From Abnormal Stomach and Intestine Function
Status: COMPLETED
Conditions: Functional Gastrointestinal Disorders
Interventions: DRUG: STW5 (Iberogast®, BAY98-7411)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Long-term Safety of Patients With Advanced Lymphoid Leukemia Who Have Been Previously Administered With UCART19
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lymphoid Leukemia
Interventions: BIOLOGICAL: UCART19 follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Smoldering Plasma Cell Myeloma
Interventions: DRUG: Leflunomide|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: eHealth Weight Loss Program in African American Breast Cancer Survivors
Status: COMPLETED
Conditions: Cancer Survivor|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage 0 Breast Cancer
Interventions: BEHAVIORAL: Behavioral Dietary Intervention|BEHAVIORAL: Exercise Intervention|DEVICE: Activity Monitoring Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of 12-week Exercise Program on Sleep Quality and Fear of Death in Geriatric Individuals
Status: COMPLETED
Conditions: Sleep Disorder|Depressive Disorder|Death|Physical Inactivity
Interventions: BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-043)
Status: RECRUITING
Conditions: Systolic Dysfunction
Interventions: DRUG: Vericiguat tablet|DRUG: Vericiguat suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Impact of the Eating Matters Program on the Nutritional Status of Medical Rehab Patients at Joseph Brant Hospital
Status: NOT_YET_RECRUITING
Conditions: Food Habits
Interventions: BEHAVIORAL: Feeding Assistance
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Modified Pillow on Safety During Breastfeeding
Status: COMPLETED
Conditions: Breastfeeding|Pregnancy Related|Newborn; Fit|Safety Issues
Interventions: DEVICE: Safe breastfeeding pillow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Jincaopian Tablets on Chronic Pelvic Pain After Pelvic Inflammatory Disease
Status: RECRUITING
Conditions: Chronic Pelvic Pain
Interventions: DRUG: Jincaopian Tablets|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ImpleMentAll - Towards Evidence-based Tailored Implementation Strategies for eHealth
Status: COMPLETED
Conditions: Tailored Implementation: Online ItFits-toolkit|Implementation as Usual
Interventions: OTHER: ItFits-toolkit|OTHER: Implementation as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Impact of Rugae Reproduction on Complete Dentures Patients' Satisfaction
Status: COMPLETED
Conditions: Edentulous Jaw
Interventions: OTHER: Addition of palatal rugae to the complete denture surface|OTHER: The removal of the palatal rugae from the complete denture surface
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: BRIGHT Coaching Program for Families
Status: COMPLETED
Conditions: Mental Health Wellness 1|Parent-Child Relations|Child Developmental Delay|Parenting|Parent-child Problem|Child Development Disorder|Autism Spectrum Disorder
Interventions: BEHAVIORAL: Coaching|BEHAVIORAL: Online parent education|BEHAVIORAL: Online peer support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: WT-1 Analog Peptide Vaccine in Acute Myeloid Leukemia (AML) or Acute Lymphoblastic Leukemia (ALL)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: WT1 peptide vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Evaluation of curQ+ Curcumin Formulation
Status: ACTIVE_NOT_RECRUITING
Conditions: Bioavailability
Interventions: DIETARY_SUPPLEMENT: 95% curcumin extract powder|DIETARY_SUPPLEMENT: curQ+ curcumin formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of LX3305 in Subjects With Active Rheumatoid Arthritis on Stable Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: LX3305 low dose|DRUG: LX3305 mid dose|DRUG: LX3305 high dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2/3 Study to Evaluate the Efficacy and Safety of Tinlarebant in Subjects With Stargardt Disease
Status: RECRUITING
Conditions: STGD1|Stargardt Disease 1
Interventions: DRUG: Tinlarebant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Enzalutamide in Combination With Gemcitabine and Nab-Paclitaxel for the Treatment of Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Enzalutamide|DRUG: Gemcitabine|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Egg Albumin-Based Protein Supplement Versus Renal-specific Supplement in Hemodialysis Patients
Status: UNKNOWN
Conditions: Protein-Energy Malnutrition|Kidney Failure, Chronic|Hemodialysis
Interventions: DIETARY_SUPPLEMENT: Egg albumin-based protein supplement|DIETARY_SUPPLEMENT: Renal-specific oral supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Using Peanut Ball on the Length of Labor for Women Laboring With an Epidural
Status: COMPLETED
Conditions: Labor|Epidural Anesthesia
Interventions: BEHAVIORAL: use peanut ball
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Therapeutic Recreation Activities on Emotional Adjustment of Individuals With Intellectual Disabilities
Status: COMPLETED
Conditions: Emotional Adjustment|Intellectual Disability
Interventions: BEHAVIORAL: Therapeutic recreation activity program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prevention Chemotherapy Induced Mucositis by Zinc Sulfate
Status: COMPLETED
Conditions: Mucositis|Bone Marrow Transplantation
Interventions: DRUG: Zinc Sulfate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sedation in ICU Patients With Mechanical Ventilation
Status: NOT_YET_RECRUITING
Conditions: Respiration, Artificial|Hypnotics and Sedatives
Interventions: DRUG: Sedation with Ciprofol|DRUG: Sedation with Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antiseizure Medication in Seizure Networks at Early Acute Brain Injury
Status: RECRUITING
Conditions: Brain Injuries, Acute|Brain Injuries, Traumatic|Brain Ischemia|Brain Hypoxia|Hypoxia-Ischemia, Brain|Heart Arrest|Stroke|Intracranial Hemorrhages|Coma|Persistent Vegetative State
Interventions: DRUG: Phenobarbital Sodium Injection|DRUG: Levetiracetam|DRUG: Lacosamide Injectable Product|DRUG: Valproate Sodium|DRUG: Phosphenytoin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Low-intensity Focused Ultrasound Pressure
Status: NOT_YET_RECRUITING
Conditions: Somatic Pain
Interventions: DEVICE: low-intensity focused ultrasound - low pressure|DEVICE: low-intensity focused ultrasound - medium pressure|DEVICE: low-intensity focused ultrasound - high pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cognitive-Behavioral Therapy for Adults With Attention-Deficit/Hyperactivity Disorder Inattentive Presentation
Status: ACTIVE_NOT_RECRUITING
Conditions: ADHD Predominantly Inattentive Type
Interventions: BEHAVIORAL: Cognitive-behavioral therapy (Hesslinger protocol)|BEHAVIORAL: Cognitive-behavioral therapy (CADDI protocol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decatecholaminisation of Septic Shock With Dexmedetomidine and In-hospital Mortality
Status: COMPLETED
Conditions: Septic Shock|Sepsis
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3-Month Home-based Training With Whole Body Vibration Device in Patients With PAH (GALILEO-PAH-HOME)
Status: UNKNOWN
Conditions: Changes in Six Minute Walking Distance, Peak Oxygen Uptake, Quality of Life
Interventions: DEVICE: Body Vibration platform GALILEO|OTHER: exercises at home on the floor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Vitreosolve® for Non-Proliferative Diabetic Retinopathy Subjects
Status: TERMINATED
Conditions: Diabetic Retinopathy
Interventions: DRUG: Vitreosolve
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Study of Families With Melanoma
Status: UNKNOWN
Conditions: Melanoma (Skin)
Interventions: GENETIC: gene expression analysis|GENETIC: mutation analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|PROCEDURE: examination|PROCEDURE: mutation carrier screening|PROCEDURE: study of high risk factors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ureteroscopy With High-powered Holmium:Yag Laser Lithotripsy With and Moses On or Moses Off
Status: RECRUITING
Conditions: Kidney Stone|Ureteral Stone
Interventions: PROCEDURE: Dusting without Moses 2.0 Modulation|PROCEDURE: Dusting with Moses 2.0 Modulation|OTHER: Moses 2.0 Modulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Hemodialysis Induced Recurrent Brain Injury to Improve Patients' Lives
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: OTHER: Intervention Arm|OTHER: Control Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Plaquenil on Serum Inflammatory Markers and Goiter in Euthyroid Young Women With Hashimoto's Thyroiditis
Status: UNKNOWN
Conditions: Hashimoto's Thyroiditis
Interventions: DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MCNAIR Study: coMparative effeCtiveness of iN-person and teleheAlth cardIac Rehabilitation
Status: RECRUITING
Conditions: Myocardial Infarction|Heart Failure, Systolic|Heart Valve Diseases|Angina, Stable|Coronary Artery Disease|Heart Transplant
Interventions: BEHAVIORAL: In-person cardiac rehabilitation|BEHAVIORAL: Telehealth cardiac rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pamiparib Combined With Surufatinib for the Neoadjuvant Treatment of Unresectable Ovarian Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: Pamiparib|DRUG: Surufatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arsenic Trioxide, Cytarabine, and Idarubicin in Treating Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: filgrastim|DRUG: arsenic trioxide|DRUG: cytarabine|DRUG: idarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 2 Weeks of Citrulline Supplementation on Arterial Function in Postmenopausal Women With Elevated Blood Pressure or Hypertension
Status: RECRUITING
Conditions: Menopause|Hypertension
Interventions: DIETARY_SUPPLEMENT: L-Citrulline|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Availability and Advice on Test Uptake During the COVID-19 Pandemic: a Vignette Study.
Status: COMPLETED
Conditions: COVID-19
Interventions: BEHAVIORAL: Customised testing advice|BEHAVIORAL: Regular testing advice|BEHAVIORAL: LFT available|BEHAVIORAL: No LFT available
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Sodium Hyaluronate to Provide Symptomatic Relief of Lateral Epicondylosis (Tennis Elbow)
Status: WITHDRAWN
Conditions: Epicondylitis|Tennis Elbow|Epicondylosis
Interventions: DEVICE: OVT (Sodium Hyaluronate)|DEVICE: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety and Efficacy of Trexima in the Acute Treatment of Migrane Headaches
Status: COMPLETED
Conditions: Migraine Headaches
Interventions: DRUG: sumatriptan|DRUG: naproxen sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Tailoring P2Y12 Inhibiting Therapy in Patients Requiring Oral Anticoagulation After PCI
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DRUG: Ticagrelor 60mg|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GDC-0084 in Combination With Trastuzumab for Patients With HER2-Positive Breast Cancer Brain Metastases
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab|DRUG: GDC-0084
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Second Phase of the Pilot Study for Obtaining Mature Oocytes by in Vitro Maturation in Oocyte-donor Women
Status: RECRUITING
Conditions: Infertility, Female|Oocyte Maturation
Interventions: DRUG: Controlled ovarian stimuation|PROCEDURE: Oocyte pick up|PROCEDURE: Oocyte in vitro maturation|PROCEDURE: Oocyte in vitro activation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: An Observational Real World Study on the Efficacy and Safety of Toripalimab Injection Combined With TACE in the Treatment of Extrahepatic Cholangiocarcinoma
Status: UNKNOWN
Conditions: Extrahepatic Cholangiocarcinoma
Interventions: DRUG: Toripalimab, Gemcitabine,Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Multicentre Trial to Evaluate the Utilization of Revascularization or Optimal Medical Therapy for the Treatment of Chronic Total Coronary Occlusions
Status: COMPLETED
Conditions: Chronic Stable Angina|Dyspnea|Coronary Occlusion
Interventions: DEVICE: Biolimus-eluting stent implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Of Implant Position Achieved With Fully Guided Versus Partially Guided Implant Placement
Status: NOT_YET_RECRUITING
Conditions: Implant Placement
Interventions: PROCEDURE: guided implant surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Serotonin Transporter Availability for Prognosing Major Depressive Disorder (MDD) Treatment and Detecting MDD
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Sertraline HCl|OTHER: I-123-ADAM SPECT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clarithromycin as Adjuvant to Periodontal Debridement
Status: COMPLETED
Conditions: Aggressive Periodontitis
Interventions: DRUG: Clarithromycin|DRUG: Placebo|OTHER: One-stage full-mouth ultrasonic debridement (FMUD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ketone Levels Achieved After Medium Chain Triglyceride (MCT) Oil
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DIETARY_SUPPLEMENT: Medium Chain Triglyceride oil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Including Sprints During Low-intensity Cycling Exercises on Performance and Muscle/Blood Characteristics
Status: COMPLETED
Conditions: Healthy|Cyclists
Interventions: BEHAVIORAL: Inclusion of sprints during low-intensity cycling during a 14-day training camp (high training load)|BEHAVIORAL: Low-intensity cycling during a 14-day training camp (high training load)|BEHAVIORAL: Recovery for 10 days (low training load)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long-term Extension of Phase 3 Study of ALZ- 801 in APOE4/4 Early AD Subjects
Status: ENROLLING_BY_INVITATION
Conditions: Early Alzheimer's Disease
Interventions: DRUG: Experimental: ALZ-801
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial
Status: COMPLETED
Conditions: Subarachnoid Hemorrhage, Aneurysmal|Delayed Cerebral Ischemia|Vasospasm, Cerebral|Endothelial Dysfunction
Interventions: DRUG: GSK2256294|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Binimetinib and Encorafenib for the Treatment of Metastatic Melanoma and Central Nervous System Metastases
Status: RECRUITING
Conditions: Clinical Stage IV Cutaneous Melanoma AJCC v8|Metastatic Melanoma|Pathologic Stage IV Cutaneous Melanoma AJCC v8
Interventions: DRUG: Binimetinib|DRUG: Encorafenib|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medtronic Evolut Transcatheter Aortic Valve Replacement in Low Risk Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: Medtronic Transcatheter Aortic Valve Replacement Systems|DEVICE: Surgical Aortic Valve Replacement (SAVR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propranolol Versus Placebo for Induction of Labor in Nulliparous Patients
Status: COMPLETED
Conditions: Induction of Labor Affected Fetus / Newborn
Interventions: DRUG: Propranolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Predictive Accuracy of MATRx Plus in Identifying Favorable Candidates for Oral Appliance Therapy
Status: COMPLETED
Conditions: Sleep Apnea|Sleep Apnea, Obstructive|Sleep Disordered Breathing
Interventions: DEVICE: MATRx plus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of the Efficiency of the Technology-Based Psychosocial Empowerment Program Program
Status: NOT_YET_RECRUITING
Conditions: Cancer|Child, Only|Empowerment|Parents
Interventions: OTHER: Technology Based Psychosocial Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Evaluate the Short-term and Long Term Efficacy of Acupuncture in Ocular and Oral Dryness Symptoms of Dry Eye Syndrome
Status: RECRUITING
Conditions: Dry Eye Syndrome|Xerophthalmia
Interventions: PROCEDURE: Acupuncture|DIAGNOSTIC_TEST: Oral microbiota|DIAGNOSTIC_TEST: Schirmer's test|DIAGNOSTIC_TEST: Tear breakup time|DIAGNOSTIC_TEST: OSDI(Ocular Surface Disease Index)|DIAGNOSTIC_TEST: TCM pattern|DIAGNOSTIC_TEST: Traditional Chinese Medicine (TCM) tongue diagnosis|DIAGNOSTIC_TEST: TCM pulse diagnosis|DIAGNOSTIC_TEST: TCM heart rate variability|DIAGNOSTIC_TEST: ESSPRI(EULAR Sjögren's Syndrome Patient Reported Index)|DIAGNOSTIC_TEST: Whole-genome genotyping(TWBv2.0)|DIAGNOSTIC_TEST: Cytokine markers|DIAGNOSTIC_TEST: Blood biochemical analysis|DIAGNOSTIC_TEST: complete blood count (CBC)|DIAGNOSTIC_TEST: SF-36(36-Item Short Form Survey )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: 6-Month Safety And Efficacy Study Of TTP488 In Patients With Type 2 Diabetes And Persistent Albuminuria
Status: COMPLETED
Conditions: Diabetic Nephropathy
Interventions: DRUG: PF-04494700 (TTP488)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of the Effectiveness of Probiotics and Lactitol for the Decolonization of OXA-48 (Carbapenemase) Producing Klebsiella Pneumoniae Among Rectal Carriers
Status: UNKNOWN
Conditions: Bacterial Colonization
Interventions: DRUG: Lactitol|DRUG: Lactobacillus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Management After Total Shoulder Arthroplasty
Status: TERMINATED
Conditions: Glenohumeral Arthritis|Total Shoulder Arthroplasty
Interventions: DRUG: Ropivacaine|DRUG: liposomal bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation in the Treatment of Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer Stage III|Pancreatic Cancer Stage IV
Interventions: DRUG: Gemcitabine|OTHER: GPBSC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine -diphthEria -tetaNus -Acellular pertUssis-inactivated polioviruS
Status: COMPLETED
Conditions: Diphtheria|Tetanus|Pertussis|Poliomyelitis
Interventions: BIOLOGICAL: DTaP-IPV combination vaccine|BIOLOGICAL: DTaP vaccine and IPV vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of Adjunctive Rosiglitazone in the Treatment of Uncomplicated Falciparum Malaria
Status: COMPLETED
Conditions: Falciparum Malaria
Interventions: DRUG: Rosiglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Memory Disorders in Gulf War Illness With High Definition Transcranial Direct Cortical Stimulation
Status: RECRUITING
Conditions: Memory Disorders|Word Finding Difficulty
Interventions: DEVICE: High Definition Transcranial Direct Current Stimulation|DEVICE: Sham High Definition Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RAS-Peptide-Profile Study in Healthy Male Subjects
Status: COMPLETED
Conditions: RAS Peptide Profile in Healthy Volunteers
Interventions: DRUG: ACEI-ARB-RI|DRUG: ARB-RI-ACEI|DRUG: RI-ACEI-ARB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Identification of Etiopathological and Clinical Factors in Persistent Genital Arousal Disorder
Status: COMPLETED
Conditions: Restless Genital Syndrome|Sexual Arousal Disorder|Orgasmic Disorder|Psychosexual Disorder
Interventions: DIAGNOSTIC_TEST: Psychological/psychiatric examination|DIAGNOSTIC_TEST: Neurological examination|DIAGNOSTIC_TEST: Gynecological/urological examination|DIAGNOSTIC_TEST: Laboratory assessment|DIAGNOSTIC_TEST: Structural and Functional Magnetic Resonance Imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intracutaneous Sterile Water Injections for Acute Low Back Pain in the Emergency Department
Status: TERMINATED
Conditions: Low Back Pain
Interventions: OTHER: Intracutaneous sterile water injections (ISWI) group|OTHER: Intracutaneous dry injections (IDI) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Plasma Transfusion in Liver Transplantation
Status: COMPLETED
Conditions: Bleeding in Liver Transplantation
Interventions: OTHER: plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interventions to Help More Low-income Smokers Quit
Status: COMPLETED
Conditions: Tobacco Use Cessation|Smoking Behaviors|Health Disparity
Interventions: BEHAVIORAL: Tobacco Quitline|BEHAVIORAL: Smoke Free Home
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: IT-hu14.18-IL2 With Radiation, Nivolumab and Ipilimumab for Melanoma
Status: SUSPENDED
Conditions: Melanoma
Interventions: BIOLOGICAL: hu14.18-IL2|RADIATION: Radiation Therapy|BIOLOGICAL: Nivolumab|BIOLOGICAL: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ARMS - Rapidly Generated Multivirus-Specific CTLs for Prophylaxis & Treatment of EBV, CMV, Adenovirus, HHV6 & BK Virus
Status: COMPLETED
Conditions: Viral Infection
Interventions: BIOLOGICAL: Multivirus-specific T cells Dose Level 1|BIOLOGICAL: Multivirus-specific T cells Dose Level 2|BIOLOGICAL: Multivirus-specific T cells Dose Level 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Etoposide, Methylprednisolone, High-dose Cytarabine and Oxaliplatin as 2nd Line Therapy for Non-Hodgkin's Lymphoma (NHL)
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DPOS Versus GnRH Antagonist Protocol for Oocyte Accumulation in Low Ovarian Reserve Patients: An RCT
Status: RECRUITING
Conditions: Diminished Ovarian Reserve
Interventions: PROCEDURE: Dydrogesterone priming ovarian stiumulation protocol|PROCEDURE: GnRH antagonist protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Allogeneic MSCs in Promoting T-regulatory Cells in Patients With Small Abdominal Aortic Aneurysms
Status: TERMINATED
Conditions: Abdominal Aortic Aneurysm
Interventions: BIOLOGICAL: 1 million MSCs/kg|BIOLOGICAL: 3 million MSCs/kg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT