pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy of Ramelteon on Transient Insomnia in Healthy Adults
Status: COMPLETED
Conditions: Transient Insomnia
Interventions: DRUG: Ramelteon|DRUG: Ramelteon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Platelet-rich Plasma for Treatment of Trigger Finger
Status: UNKNOWN
Conditions: Tendon Entrapment
Interventions: OTHER: PRP injection|OTHER: Corticosteroid injection|OTHER: Placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inferior Venacava Ultrasound to Guide Fluid Management for Prevention of Hypotension After Spinal Anesthesia.
Status: COMPLETED
Conditions: Hypotension|Fluid Overload
Interventions: OTHER: Inferior venacava Ultrasonography (IVC USG) guided fluid management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Surgical Plate Osteosynthesis of Distal Radius Fractures
Status: TERMINATED
Conditions: Distal Radius Fractures
Interventions: DEVICE: Locking Compression Plate 2,4mm|DEVICE: Locking Compression Plate 3,5mm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HIV Antigen-specific T-cells Targeting Conserved Epitopes (HST-NEETs) BMTCTN1903
Status: RECRUITING
Conditions: HIV Associated Lymphoma
Interventions: BIOLOGICAL: HST-NEETs|BIOLOGICAL: Bone Marrow Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Post-Op Narcotic Usage in Patients Receiving Periarticular Exparel vs. Standard Periarticular Joint Inj
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee
Interventions: DRUG: (Bupivacaine Liposome Injectable Suspension)|DRUG: Standard Preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine, Oseltamivir and Azithromycin for the Treatment of COVID-19 Infection: An RCT
Status: COMPLETED
Conditions: COVID 19
Interventions: DRUG: Hydroxychloroquine|DRUG: Oseltamivir|DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Performance of PEEK Anchors (Dynomite, Spyromite, Raptomite) in Extremities
Status: COMPLETED
Conditions: Medial or Lateral Instability Repairs/Reconstructions|Hallux Valgus Repairs|Achilles Tendon Repairs/Reconstructions|Midfoot Reconstructions|Metatarsal Ligament/Tendon Repairs/Reconstructions|Bunionectomy|Scapholunate Ligament Reconstructions|Ulnar|Lateral Epicondylitis Repair|Bicep Tendon Reattachments
Interventions: DEVICE: Spyromite, Dynomite, Raptomite, Footprint Ultra PK SL
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety and Effectiveness Study of Pre-operative Artesunate in Stage II/III Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer|Bowel Cancer
Interventions: DRUG: Artesunate 200mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Entresto Effect on Sympathic Nervous System in Patient With Heart Failure
Status: TERMINATED
Conditions: Heart Failure
Interventions: DRUG: valsartan/sacubitril 100 mg|DRUG: valsartan/sacubitril 200 mg|PROCEDURE: Microneurography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Vacuum Drain and Passive Drain In Abdominoplasty
Status: RECRUITING
Conditions: Abdominoplasty Surgery
Interventions: DEVICE: Vacuum Drain and Passive Drain insertion at abdominoplasty surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Ultrasound Assessment of Metoclopramide Effect on Gastric Volume in Cesarean Section
Status: UNKNOWN
Conditions: Aspiration Pneumonia
Interventions: DRUG: normal saline|DRUG: Metoclopramide 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I/II Study of Bosutinib in Combination With Inotuzumab Ozogamicin in CD22-positive PC Positive ALL and CML
Status: COMPLETED
Conditions: B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Blasts More Than 5 Percent of Bone Marrow Nucleated Cells|CD22 Positive|Philadelphia Chromosome Positive, BCR-ABL1 Positive Chronic Myelogenous Leukemia|Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Interventions: DRUG: Bosutinib|BIOLOGICAL: Inotuzumab Ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Immunology Study of a Modified Vaccinia Vaccine for HER-2(+) Breast Cancer After Adjuvant Therapy
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: MVA-BN-HER2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis
Status: COMPLETED
Conditions: Uveitis|Uveitis, Posterior|Uveitis, Anterior|Uveitis, Intermediate|Panuveitis
Interventions: DRUG: 4mg CLS-TA Suprachoriodal Injection|DRUG: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Research Study of How Faster-acting Insulin Aspart Moves Into, Through, and Out of the Body and How it Works in the Body When Given Through an Insulin Pump to People With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: Faster-acting insulin aspart|DRUG: Insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Feasibility Study With Patients Who Are at High Risk For Developing Invasive Candidiasis in a Critical Care Setting (MK-0991-067)
Status: TERMINATED
Conditions: Invasive Candidiasis
Interventions: DRUG: Caspofungin acetate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Cervical Exercise Combined With Nerve Mobilization on Cervical Spondylotic Radiculopathy
Status: RECRUITING
Conditions: Radiculopathy, Cervical
Interventions: OTHER: cervical spine exercises|OTHER: Neuromobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Trans Arterial Chemoembolization (TACE), Followed by Stereotactic Radiation Therapy (SBRT) for Patients With Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma (HCC)
Interventions: COMBINATION_PRODUCT: Stereotactic Body Radiation Therapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of IV Doses of Rivipansel on Subjects With Renal Impairment and in Healthy Subjects
Status: COMPLETED
Conditions: Renal Impairment|Healthy
Interventions: DRUG: Rivipansel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: SARS-COV-2 Screening in Dialysis Facilities
Status: COMPLETED
Conditions: End-stage Renal Disease|SARS-CoV-2 Acute Respiratory Disease|Dialysis; Complications
Interventions: BEHAVIORAL: Offering SARS-CoV-2 test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Post-corticosteroid Insufficiency: Search for a Threshold Value for Cortisol at 8 Hours, Prospective Study
Status: NOT_YET_RECRUITING
Conditions: Glucocorticoid-induced Adrenal Insufficiency
Interventions: DIAGNOSTIC_TEST: Salivary cortisol dosage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Adding Deep Front Line Myofascial Release to Selected Exercises in Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: exercises|OTHER: myofascial release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of the 4 Channel NMES on Swallowing
Status: COMPLETED
Conditions: Dysphagia
Interventions: DEVICE: 4 channel Electrical Stimulation Device|DEVICE: 2 channel Electrical Stimulation Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of VLP-Polio in Infants and Toddlers
Status: NOT_YET_RECRUITING
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: Recombinant Trivalent Poliomyelitis Vaccine (Sf-RVN Cell) (VLP-Polio) low adjuvant dose|BIOLOGICAL: VLP-Polio medium dose|BIOLOGICAL: VLP-Polio high dose|BIOLOGICAL: Vaccine Poliomyelitis Inactivated (IPV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety and Pharmacokinetics of Inhaled Ciprofloxacin in Patients With Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Disease, Pulmonary
Interventions: DRUG: Ciprofloxacin (Cipro inhale, BAYQ3939)|DRUG: Ciprofloxacin (Cipro inhale, BAYQ3939)|DRUG: Ciprofloxacin (Cipro inhale, BAYQ3939)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy and Chemotherapy Followed by Surgery and Combination Chemotherapy in Treating Patients With Rectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: fluorouracil|DRUG: leucovorin calcium|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Value of Sintilimab Consolidation Therapy After Definitive Concurrent Chemoradiotherapy for Locally Advanced Thoracic Esophageal Cancer
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Lyophilized Plasma in Patients on Warfarin
Status: WITHDRAWN
Conditions: Anticoagulant Therapy
Interventions: BIOLOGICAL: Lyophilized Plasma|BIOLOGICAL: Licensed Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Placebo-controlled Trial With OROS Hydromorphone Hydrochloride to Treat Patients With Moderate to Severe Pain Induced by Osteoarthritis of the Hip or the Knee
Status: COMPLETED
Conditions: Pain|Osteoarthritis, Hip|Osteoarthritis, Knee
Interventions: DRUG: OROS hydromorphone HCl|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Oxygen Concentrations on Pulmonary Complications in Patients Undergoing Radical Resection of Esophageal Cancer
Status: RECRUITING
Conditions: Atelectasis, Postoperative
Interventions: DRUG: 30%Oxygen|DRUG: 60%Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study to Assess Drug-drug Interaction Between Zanubrutinib and a Cocktail of Substrates in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: BGB-3111 and Drug Cocktail
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/IIa Study of the Safety, Immunogenicity and Efficacy of FMP2.1/AS01B, an Asexual Blood-Stage Vaccine for Plasmodium Falciparum Malaria
Status: COMPLETED
Conditions: Plasmodium Falciparum Malaria
Interventions: BIOLOGICAL: FMP2.1/AS01B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vaccine Treatment for Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Carcinoma|Adenocarcinoma of Lung|Squamous Cell Carcinoma|Large Cell Carcinoma|Lung Neoplasms
Interventions: BIOLOGICAL: Drug: Hyperacute Lung Cancer Cell Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET/CT Vs Bone Marrow Biopsy in Exclusion of Bone Marrow Infiltration for Initial Staging of Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Lymphoma
Interventions: DEVICE: positron emission tomography for exclusion of bone marrow infiltration in lymphoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Support for Low-Income Mothers of Preterm Infants
Status: NOT_YET_RECRUITING
Conditions: Preterm Birth|Low; Birthweight, Extremely (999 Grams or Less)
Interventions: OTHER: Financial Transfers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Enoxaparin in COVID-19 Moderate to Severe Hospitalized Patients
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Enoxaparin 40 Mg/0.4 mL Injectable Solution|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety, Tolerability, and Efficacy of KD01 in Cervical Malignancies
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: KD01(the recombinant oncolytic adenovirus)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Allogeneic Lymphocytes and Aldesleukin in Treating Patients With High-Risk or Recurrent Myeloid Leukemia After Undergoing Donor Stem Cell Transplant
Status: TERMINATED
Conditions: Accelerated Phase Chronic Myelogenous Leukemia|Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Blastic Phase Chronic Myelogenous Leukemia|Childhood Chronic Myelogenous Leukemia|Childhood Myelodysplastic Syndromes|Recurrent Adult Acute Myeloid Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Relapsing Chronic Myelogenous Leukemia|Secondary Acute Myeloid Leukemia
Interventions: BIOLOGICAL: therapeutic allogeneic lymphocytes|BIOLOGICAL: aldesleukin|OTHER: laboratory biomarker analysis|OTHER: flow cytometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET-Study: Effects of Single Doses of Stalevo and Levodopa/Carbidopa on Striatal 11C-Raclopride Binding
Status: TERMINATED
Conditions: Parkinson´s Disease
Interventions: DRUG: entacapone and carbidopa|DRUG: Sinemet 200mg/50mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Clinical Efficacy of Donidalorsen (Also Known as IONIS-PKK-LRx and ISIS 721744) in Participants With Hereditary Angioedema
Status: COMPLETED
Conditions: Hereditary Angioedema
Interventions: DRUG: Donidalorsen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study on N-acetylneuraminic Acid
Status: COMPLETED
Conditions: Nonaka Myopathy|Hereditary Inclusion Body Myopathy
Interventions: DRUG: NPC-09
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Propofol Concentration in Exhaled Breath and Blood Plasma Using the Exhaled Drug Monitor "Edmon"
Status: WITHDRAWN
Conditions: Elective Surgical Procedures|Anesthesia, Intravenous
Interventions: DEVICE: Exhaled drug monitor "Edmon"
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Role of Epoxy-eicosatrienoic Acids in Post-occlusive Hyperemia and Thermal Hyperemia
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Microdialysis of fluconazole, vehicle and N(G)-nitro-L-arginine-methyl ester (L-NMMA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients
Status: COMPLETED
Conditions: Shock, Hemorrhagic|Shock, Traumatic|Acidosis, Lactic
Interventions: DRUG: MP4OX|DRUG: MP4OX|DRUG: Ringers Lactate solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Frequency of Circulating Tumor Cells (CTCs) and Amount of Cell-free DNA (cfDNA) in Cirrhotic Patients With Hepatocellular Carcinoma (HCC)
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: OTHER: Cirrhosis with HCC|OTHER: Cirrhosis without HCC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Between Xarelto Versus Warfarin in the Recanalization Rate of Deep Venous Thrombosis in Patients Legs.
Status: UNKNOWN
Conditions: Deep Venous Thrombosis
Interventions: DRUG: Rivaroxaban|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Single Versus Multi-Shade Direct Composite Resin Veneers
Status: COMPLETED
Conditions: Tooth Discoloration
Interventions: OTHER: OMNICHROMA, Ceram. x spectra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Bridging Study: Comparing Two Lots of Sci-B-Vac™ and Engerix-B in Healthy Adults
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Sci-B-Vac-Lot B|BIOLOGICAL: Sci-B-Vac-Lot A|BIOLOGICAL: Engerix-B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Veliparib and Topotecan for Relapsed Ovarian Cancer With Negative or Unknown BRCA Status
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Veliparib|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Kava on Anxiety and Stress in Cancer Survivors
Status: NOT_YET_RECRUITING
Conditions: Kava|Anxiety|Stress|Cancer|Depression|Sleep
Interventions: DRUG: Kava|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intensive 7-day Treatment for PTSD Combining Ketamine With Exposure Therapy
Status: TERMINATED
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: Ketamine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective, Single-Arm, Multicenter Study to Evaluate the Effectiveness and Safety of Endovascular Treatment in Patients With Cerebral Aneurysms Using P64 and P48 Flow-Diverter Stents
Status: RECRUITING
Conditions: Cerebral Aneurysm|Thromboembolic Disease
Interventions: DEVICE: Group 1 - Intervention 1
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Carvedilol Versus Endoscopic Band Ligation for Primary Prophylaxis of Oesophageal Variceal Bleeding
Status: RECRUITING
Conditions: Esophageal Varices
Interventions: DRUG: Carvedilol|PROCEDURE: Endoscopic band ligation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Lisdexamfetamine's Effect In ADHD in the Brain and Cognition
Status: TERMINATED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Lisdexamfetamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Observational Post-marketing Study Using Commercially Approved Biosense Webster (BWI) Medical Devices for the Treatment of Participants With Cardiac Arrhythmias
Status: RECRUITING
Conditions: Cardiac Arrhythmias
Interventions: DEVICE: BWI Medical Device|DEVICE: Varipulse Catheter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pegylated Liposomal Doxorubicin Containing Chemotherapy in the Treatment of Older Non-Hodgkin's Lymphoma Patients
Status: TERMINATED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: CDOP plus rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Kangarooing Small Babies on the Back of a Mother Keep Them Warm and Stable
Status: COMPLETED
Conditions: Body Temperature|Oxygen Saturation|Heart Rate|Respiratory Rate|Sleep Pattern
Interventions: OTHER: Chest-to-back
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Pralatrexate in Treating Patients With Relapsed or Refractory Peripheral T-Cell Lymphomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Anaplastic Large Cell Lymphoma|Nodal Peripheral T-Cell Lymphoma With TFH Phenotype|Recurrent Anaplastic Large Cell Lymphoma|Recurrent Angioimmunoblastic T-Cell Lymphoma|Recurrent Enteropathy-Associated T-Cell Lymphoma|Recurrent Follicular Lymphoma|Recurrent Hepatosplenic T-Cell Lymphoma|Recurrent Mature T- Cell and NK-Cell Non-Hodgkin Lymphoma|Recurrent Monomorphic Epitheliotropic Intestinal T-cell Lymphoma|Recurrent Mycosis Fungoides|Recurrent Peripheral T-Cell Lymphoma, Not Otherwise Specified|Refractory Anaplastic Large Cell Lymphoma|Refractory Angioimmunoblastic T-Cell Lymphoma|Refractory Enteropathy-Associated T-Cell Lymphoma|Refractory Follicular Lymphoma|Refractory Hepatosplenic T-Cell Lymphoma|Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma|Refractory Mycosis Fungoides|Refractory Peripheral T-Cell Lymphoma, Not Otherwise Specified|Subcutaneous Panniculitis-Like T-Cell Lymphoma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Pralatrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study to Compare a Medicine Called Semaglutide Against Placebo in People With Peripheral Arterial Disease and Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Peripheral Arterial Disease
Interventions: DRUG: Semaglutide|DRUG: Placebo (semaglutide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colchicine in Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction
Status: RECRUITING
Conditions: HFpEF - Heart Failure With Preserved Ejection Fraction|Colchicine
Interventions: DRUG: Colchicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is Saxenda® a Viable Treatment of Obese Patients in Forensic Psychiatry?
Status: COMPLETED
Conditions: Mental Disorder|Metabolic Disturbance|Feasibility|Overweight and Obesity|Liraglutide
Interventions: DRUG: liraglutide 3 mg (Saxenda®) once-daily
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk Adapted Therapy in Diffuse Large B Cell Lymphoma
Status: UNKNOWN
Conditions: Large B Cell Lymphoma
Interventions: DRUG: rituximab, etoposide, cyclophosphamide, doxorubicin, vincristine,prednisone, filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Multiple Doses of Gemfribozil on a Single Dose of ASP3652, and to Assess the Effects of Multiple Doses of ASP3652 on a Single Dose of Repaglinide in the Body of Healthy Subjects
Status: COMPLETED
Conditions: Drug-Drug Interaction (DDI)|Healthy Subjects
Interventions: DRUG: ASP3652|DRUG: Gemfibrozil|DRUG: Repaglinide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Transcriptome Analysis of the Peripheral Blood in CIDP
Status: UNKNOWN
Conditions: Chronic Inflammatory Demyelinating Polyradiculoneuropathy|Autoimmune Diseases|Clarkson Syndrome|Muscular Autoimmune Disorders
Interventions: DRUG: IVIg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colon Cancer|Rectal Cancer
Interventions: DRUG: CoFactor|DRUG: 5-FU|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Israeli Biologic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study
Status: COMPLETED
Conditions: Pulmonary Emphysema|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Biologic Lung Volume Reduction (BLVR) - 10 mL Hydrogel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on the Effectiveness and Safety Evaluation of Combination Therapy With 1,927nm Thulium Laser and Fractional Microneedle Radiofrequency Equipment for Improvement of Skin Aging
Status: COMPLETED
Conditions: Wrinkle
Interventions: DEVICE: LUTRONIC GENUS laser(Fractional Microneedle Radiofrequency(FMR))|DEVICE: LASEMED laser(The Thulium laser with 1,927nm wavelength)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation by Electrical Impedancemetry of the Variation in Lung Volumes Under Non-invasive Ventilation (NIV) in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: COPD
Interventions: DEVICE: Electrical impedance tomography (EIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Anlotinib Plus Chemoradiotherapy in Patients With Locally Advanced NSCLC
Status: UNKNOWN
Conditions: Patients With Non-small Cell Lung Cancer
Interventions: DRUG: Simultaneous chemoradiotherapy for An Luo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Replication-Competent Adenovirus 4-vectored Vaccine for Avian Influenza H5N1
Status: COMPLETED
Conditions: Bird Flu|Influenza
Interventions: OTHER: Placebo|BIOLOGICAL: Ad4-H5-Vtn|BIOLOGICAL: Sanofi Pasteur Influenza Virus Vaccine, H5N1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Interventions and Viscoelasticity of Hamstring
Status: COMPLETED
Conditions: Injury; Back, Lower, Superficial|Hamstring Injury|Sport Injury|Sports Physical Therapy
Interventions: PROCEDURE: Ballistic Hamstring Stretching|PROCEDURE: Hamstring Extender Exercise|PROCEDURE: Kinesiotape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of FRaDCs for Ovarian Cancer
Status: RECRUITING
Conditions: Fallopian Tube Carcinosarcoma|Primary Peritoneal Carcinosarcoma|Recurrent Fallopian Tube Carcinoma|Recurrent Fallopian Tube Clear Cell Adenocarcinoma|Recurrent Fallopian Tube Endometrioid Adenocarcinoma|Recurrent Fallopian Tube High Grade Serous Adenocarcinoma|Recurrent Ovarian Carcinoma|Recurrent Ovarian Carcinosarcoma|Recurrent Ovarian Clear Cell Adenocarcinoma|Recurrent Ovarian Endometrioid Adenocarcinoma|Recurrent Ovarian High Grade Serous Adenocarcinoma|Recurrent Primary Peritoneal Carcinoma|Recurrent Primary Peritoneal Clear Cell Adenocarcinoma|Recurrent Primary Peritoneal Endometrioid Adenocarcinoma|Recurrent Primary Peritoneal High Grade Serous Adenocarcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Multi-epitope Folate Receptor Alpha-loaded Dendritic Cell Vaccine|BIOLOGICAL: Pembrolizumab|PROCEDURE: Pheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promotion of Nurses' Lower Extremity Health by Foot(at)Work Intervention
Status: NOT_YET_RECRUITING
Conditions: Lower Extremity Problem|Foot Deformities
Interventions: BEHAVIORAL: Foot(at)Work intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Role of Perforator Flaps in Back Defects Reconstruction
Status: NOT_YET_RECRUITING
Conditions: Myelomeningocele
Interventions: PROCEDURE: surgical closure of myelomeningocele defects by perforator flaps|PROCEDURE: surgical closure of myelomeningocele defects by perforator-plus flaps
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Study of Chinese Medicine for the Treatment of Primary Osteoporosis
Status: UNKNOWN
Conditions: Primary Osteoporosis
Interventions: DRUG: Caltrate D|DRUG: Chinese medicine prescription|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety Study of Glycopyrronium in Subjects With Primary Axillary Hyperhidrosis
Status: COMPLETED
Conditions: Hyperhidrosis
Interventions: DRUG: Glycopyrronium Topical Wipes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Combination of High-dose Dexamethasone and Acetylcysteine as the Treatment of Newly-diagnosed ITP
Status: UNKNOWN
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Dexamethasone|DRUG: Acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Systematic Screening for Risk-factors for Ulcer Bleeding Before Anti-thrombotic Treatment
Status: COMPLETED
Conditions: Coronary Occlusion/Thrombosis|Peptic Ulcer Hemorrhage
Interventions: OTHER: Screening for risk factors for ulcer bleeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Combined Ruxolitinib and Enasidenib in Patients With Accelerated/Blast-phase Myeloproliferative Neoplasm or Chronic-phase Myelofibrosis With an IDH2 Mutation
Status: COMPLETED
Conditions: Accelerated/Blast-phase Myeloproliferative Neoplasm|Chronic-phase Myelofibrosis|IDH2 Mutation
Interventions: DRUG: Ruxolitinib|DRUG: Enasidenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Impact of Manual Therapy on Lumbar Spinal Stenosis
Status: RECRUITING
Conditions: Lumbar Spinal Stenosis
Interventions: OTHER: Manual Therapy and Exercise|OTHER: Intramuscular Electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Guselkumab in Participants With Active Psoriatic Arthritis
Status: RECRUITING
Conditions: Arthritis, Psoriatic
Interventions: DRUG: Guselkumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RMGI Varnish Versus APF Gel in Prevention of White Spot Lesions During Orthodontic Treatment
Status: UNKNOWN
Conditions: White Spot Lesion of Tooth
Interventions: COMBINATION_PRODUCT: Acidulated phosphorous flouride|OTHER: Resin modified glass ionomer varnish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: RehabGBs: Rehabilitation in People With Guillain-Barré Syndrome
Status: RECRUITING
Conditions: Guillain-Barré Syndrome
Interventions: OTHER: Inpatient Rehabilitation|OTHER: Inspiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Remediation Program for Family Caregivers in Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Cognitive Adaptation Training for Caregivers (CAT Famille)|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Potassium Nitrate and Post-bleaching Sensitivity
Status: COMPLETED
Conditions: Medicaments Substances in Therapeutic Use
Interventions: OTHER: Placebo gel + Normal Toothpaste|OTHER: Placebo Gel + Potassium Nitrate Toothpaste|OTHER: Potassium Nitrate Gel + Normal Toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of Alvimopan Drug For Treatment Of Constipation Due To Prescription Pain Medication
Status: COMPLETED
Conditions: Constipation|Bowel Dysfunction
Interventions: DRUG: alvimopan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Dose-escalation Study Characterizing the PK of Eltrombopag in Pediatric Patients With Previously Untreated or Relapsed Severe Aplastic Anemia or Recurrent Aplastic Anemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Aplastic Anemia
Interventions: DRUG: Eltrombopag|DRUG: hATG|DRUG: CsA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Different Methods for Determining Endotracheal Cuff Pressure
Status: COMPLETED
Conditions: Anesthesia, General|Intubation, Intratracheal
Interventions: OTHER: stethoscope|OTHER: Audible leak/Balloon palpation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of FalateScan (Technetium Tc 99m EC20) in Patients With Known Suspected Recurrent or Metastatic Cancer From a Solid Tumor
Status: COMPLETED
Conditions: Recurrent or Metastatic Cancer|Head and Neck Cancer|Pancreas Cancer|Bladder Cancer|Testicular Cancer
Interventions: DRUG: Tc 99m EC20
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Non-invasive Modulation of Spinal Cord Nociceptive Reflexes
Status: ENROLLING_BY_INVITATION
Conditions: Pain
Interventions: OTHER: Transcutaneous spinal direct current stimulation (tsDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neuro-Ox 2018: Assessment of Cerebral Oxygenation Under Three Clinically Relevant Conditions
Status: COMPLETED
Conditions: Neurosurgery|Elective Craniotomy|General Anaesthesia
Interventions: DEVICE: NIRS measurements on skin, skull and dura|DRUG: Phenylephrine's effect on brain oxygenation|DRUG: Normal vs. high inspired oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bronchiectasis Alpha-1 Augmentation Trial- Modulating Airway Neutrophil Function
Status: COMPLETED
Conditions: Bronchiectasis Adult
Interventions: DRUG: Alpha 1-Proteinase Inhibitor 180mg/kg|DRUG: Alpha 1-Proteinase Inhibitor 120mg/kg|DRUG: Sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II, Open-Label Study of Clofarabine in Paediatric Patients With Refractory/Relapsed Acute Lymphoblastic Leukaemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Enhancement Therapy for Adult Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autistic Disorder|Autism Spectrum Disorder|Asperger's Syndrome|Pervasive Developmental Disorder
Interventions: BEHAVIORAL: Cognitive Enhancement Therapy|BEHAVIORAL: Enriched Supportive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Trial in Patients With Resected PDAC Randomized to Allocation of Oxaliplatin- or Gemcitabine-based Chemotherapy by Standard Clinical Criteria or by a Transcriptomic Treatment Specific Stratification Signature
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: Oxaliplatin|DRUG: Irinotecan|DRUG: Folinic acid|DRUG: 5-fluorouracil|DRUG: Gemcitabine|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Control Trial on Trauma Focused CBT in Zambia
Status: COMPLETED
Conditions: Post Traumatic Stress Disorder|Depression|Risk Behaviors
Interventions: BEHAVIORAL: Trauma Focused Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Dapagliflozin on DIAstolic Dysfunction in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Dapagliflozin 10mg|DRUG: Placebo 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the Knee
Status: COMPLETED
Conditions: Juvenile Osteochondritis Dissecans
Interventions: PROCEDURE: Retro-articular drilling|PROCEDURE: Trans-articular drilling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Cholecystectomy in Midgut NETs Patients Who Require Primary Tumor Surgery.
Status: RECRUITING
Conditions: Midgut Carcinoid Tumor|Biliary Stones
Interventions: PROCEDURE: Primary tumor surgery|PROCEDURE: Primary tumor surgery (bowel resection) combined with prophylactic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repurposing Fenofibrate in Modulating mTOR/NLRP3 Inflammasome in Patients With Ulcerative Colitis
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases
Interventions: DRUG: Mesalamine|DRUG: Fenofibrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Body Mass Index (BMI) and Metabolic Changes Following Switch to Aripiprazole From Olanzapine, Risperidone and Quetiapine
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder|Mood Disorders
Interventions: DRUG: Aripiprazole
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Relative Bioavailability Study of Four Experimental Formulations for Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease|Healthy
Interventions: DRUG: BMS-708163|DRUG: BMS-708163|DRUG: BMS-708163|DRUG: BMS-708163|DRUG: BMS-708163
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Safety, Clinical Activity, Pharmacokinetics (PK) and Pharmacodynamics Study of GSK2879552, Alone or With Azacitidine, in Subjects With High Risk Myelodysplastic Syndromes (MDS)
Status: TERMINATED
Conditions: Myelodysplastic Syndrome|Myelodysplastic Syndromes
Interventions: DRUG: GSK2879552|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evening Primrose Oil to Misoprostol During Induction of Second-trimester Missed Miscarriage
Status: COMPLETED
Conditions: Missed Abortion
Interventions: DRUG: Misoprostol 100Mcg Tab|DRUG: Evening Primrose Oil 1000 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Helical Tomotherapy in Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: RADIATION: Total Marrow irradiation，TMI|PROCEDURE: Autologous hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of College Students With Attention-Deficit/Hyperactivity Disorder (ADHD) Using OROS Methylphenidate
Status: WITHDRAWN
Conditions: Attention-Deficit/Hyperactivity Disorder (ADHD)
Interventions: DRUG: methylphenidate HCl (Concerta)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/IIa Study Evaluating Safety and Efficacy of an Intratympanic Dose of PIPE-505 in Subjects With Hearing Loss
Status: COMPLETED
Conditions: Sensorineural Hearing Loss
Interventions: DRUG: PIPE-505|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early and Late Effects of Nefopam in Multimodal Analgesia After Total Hip Arthroplasty (NEFARTHRO)
Status: NOT_YET_RECRUITING
Conditions: Total Hip Arthroplasty
Interventions: DRUG: Nefopam|DRUG: Nefopam|DRUG: NaCl 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CTx-1301 Comparative Bioavailability Study
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: Dexmethylphenidate 5 Mg Oral Capsule, Extended Release|DRUG: Dexmethylphenidate 6.25 mg Tablet|DRUG: Dexmethylphenidate 40 Mg Oral Capsule, Extended Release|DRUG: Dexmethylphenidate 50 mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease)
Status: UNKNOWN
Conditions: Crohn's Disease
Interventions: DRUG: Probiotic|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Recombinant Human Serum Albumin/Interferon alpha2a Fusion Protein Phase I Study in Chinese Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: Human Serum Albumin/interferon alpha2a 300-1200 mcg single dose S.C.|BIOLOGICAL: Peginterferon 180 mcg single dose S.C.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT