pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Does Cefoxitin or Piperacillin-Tazobactam Prevent Postoperative Surgical Site Infections After Pancreatoduodenectomy?
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer|Pancreas Cancer|Pancreatic Diseases
Interventions: DRUG: Cefoxitin|DRUG: Piperacillin-tazobactam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of the Efficacy and Safety of Endoscopic Tissue Apposition
Status: RECRUITING
Conditions: Endoscopic Tissue Apposition|Endoscopic Suturing|Endoscopic Clipping|Bariatric Endoscopy|Transoral Outlet Reduction|Endoscopic Sleeve Gastroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Pharmacokinetic Interaction Between Pirfenidone and BMS-986278 in Healthy Participants
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis (IPF)
Interventions: DRUG: BMS-986278|DRUG: Pirfenidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cross Cultural Validation of the Italian Version of the Clinical Assessment of Dysphagia in Neurodegeneration
Status: RECRUITING
Conditions: Swallowing Disorder|Dysphagia|Neuro-Degenerative Disease
Interventions: OTHER: Administration of Clinical Assessment of Dysphagia in Neurodegeneration (CADN)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CMO Letter to Reduce Unnecessary Antibiotic Prescribing and Broad Spectrum Prescribing Winter 2018-9
Status: COMPLETED
Conditions: Prescribing, Off-Label
Interventions: BEHAVIORAL: new social norm feedback letter with bar chart|BEHAVIORAL: standard social norm feedback letter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Laser Vaginal Treatment for SUI
Status: ACTIVE_NOT_RECRUITING
Conditions: Stress Urinary Incontinence
Interventions: PROCEDURE: Erbium-YAG laser vaginal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Treatment of Patients With Major Depressive Disorder With MK0869 (0869-065)(COMPLETED)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: aprepitant|DRUG: Comparator: placebo (unspecified)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tirbanibulin on the Wellbeing of Participants With Actinic Keratoses
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Tirbanibulin 2.5 mg ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Femara (Letrozole) Versus Placebo for Patients With Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Status: WITHDRAWN
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Cancer
Interventions: DRUG: Femara|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electric Polarization of Red Blood Cells : A Cohort Study to Assess the Erythrocytes Membrane Integrity Through Charge Conservation, Following Cardiac Surgery.
Status: WITHDRAWN
Conditions: Inflammatory Response|Erythrocyte Destruction|Red Blood Cell Disorder|Hemolysis|Cardiovascular Disorder
Interventions: DIAGNOSTIC_TEST: Polarization of red blood cells
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Perfusion and Hypoxia Evaluation in Tumors Using 18F-FDG PET/CT
Status: UNKNOWN
Conditions: Perfusion and Hypoxia
Interventions: DIAGNOSTIC_TEST: 18F-FDG PET/CT initial-time imaging|DIAGNOSTIC_TEST: 18F-FDG PET/CT balanced-time imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy Study of Eculizumab in Patients With Refractory Generalized Myasthenia Gravis
Status: TERMINATED
Conditions: Myasthenia Gravis
Interventions: DRUG: eculizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Two Doses of HIL-214 in Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastroenteritis
Interventions: BIOLOGICAL: HIL-214|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Manual Therapy Combined With Therapeutic Exercise on Brain Biomarkers in Neck Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: Manual therapy combinded with therapeutic exercise|OTHER: Routine physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Varenicline OTC Trial on Efficacy and Safety
Status: COMPLETED
Conditions: Tobacco Dependence|Withdrawal Symptoms|Smoking Cessation
Interventions: DRUG: 1.0mg Varenicline b.i.d.|DRUG: 0.5mg Varenicline b.i.d.|DRUG: 0.0mg placebo Varenicline b.i.d.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Precision Allergy: Separate Allergies to Male and Female Dogs
Status: COMPLETED
Conditions: Allergy; Dander
Interventions: DIAGNOSTIC_TEST: Male dog|DIAGNOSTIC_TEST: Female dog
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Exercise and Activities for Independent Living With Mild Cognitive Impairment (MCI)
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Dementia
Interventions: BEHAVIORAL: Resources and Activities for Life Long Independence (RALLI)|BEHAVIORAL: Social Walking program (SW)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Combination With Copegus (Ribavirin) in Patients With Chronic Hepatitis C (CHC) Enrolled in a Methadone Maintenance Treatment Program.
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: peginterferon alfa-2a [Pegasys]|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Swab Testing to Optimize Pneumonia Treatment With Empiric Vancomycin
Status: ENROLLING_BY_INVITATION
Conditions: Community-acquired Pneumonia
Interventions: DIAGNOSTIC_TEST: MRSA Nasal Swab PCR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Lengthening the Interval Between Radiochemotherapy and Surgery on Complete Pathological Response in Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: PROCEDURE: Surgery after 11 weeks of delay after chemoradiotherapy.|PROCEDURE: Surgery after 7 weeks of delay after chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rheolytic Thrombectomy in Patients With Acute STEMI and Large Thrombus Burden
Status: UNKNOWN
Conditions: ST Elevation Myocardial Infarction|STEMI
Interventions: PROCEDURE: Rheolytic Thrombectomy|PROCEDURE: Conventional PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label Study to Assess the Absorption, Metabolism, Excretion, and Mass Balance of a Single Oral Dose of [14C]-20 mg/100 μCi Anaprazole Sodium Enteric-coated Capsule in Healthy Adult Male Subjects
Status: UNKNOWN
Conditions: Healthy Male Volunteers
Interventions: DRUG: [14C]-Anaprazole Sodium enteric-coated capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Cobiprostone in Patients With Portal Hypertension
Status: TERMINATED
Conditions: Portal Hypertension
Interventions: DRUG: Placebo|DRUG: Cobiprostone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drospirenone/Ethinyl Estradiol (3 mg/0.02 mg) Tablets Under Fasting Conditions.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Drospirenone/Ethinyl Estradiol (Gianvi®)|DRUG: YAZ®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Evaluation of the Efficacy and the Safety of a Stereotaxic Prostatic Radiotherapy Delivered With Linac MRI, in Patients With Prostate Adenocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Adenocarcinoma of the Prostate
Interventions: RADIATION: Stereotactic Radiotherapy with Linac MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identifying Maturity-onset Diabetes of the Young in Emirati Patients
Status: NOT_YET_RECRUITING
Conditions: Maturity-onset Diabetes of the Young|Monogenic Diabetes|MODY
Interventions: DIAGNOSTIC_TEST: Genetic testing for 4 MODY genes (GCK, HNF1A, HNF4A, HNF1B)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Lidocaine Phonophoresis Versus Pulsed Ultrasound on Myofascial Pain Syndrome in Athletic Children
Status: COMPLETED
Conditions: Treatment Side Effects
Interventions: DRUG: Lidocaine|DEVICE: pulsed ultrasound|OTHER: especially designed physical therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nitric Oxide (NO) on Ischemic/Reperfusion Injury During Extended Donor Criteria (EDC) Liver Transplantation
Status: TERMINATED
Conditions: Liver Transplantation|Ischemia/Reperfusion Injury|Oxidative Injury
Interventions: DRUG: Nitric Oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Transpulmonary Thermodilution and Continuous Monitoring of Central Venous Oxygen Saturation During Off-pump Coronary Surgery
Status: COMPLETED
Conditions: Coronary Artery Disease|Hemodynamic Monitoring|Goal Directed Therapy
Interventions: DEVICE: Conventional monitoring|DEVICE: Advanced monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Modified XELOX Plus Sintilimab With Standard XELOX Plus Sintilimab in First-line Treatment for HER2-negative Gastric/Gastroesophageal Junction Adenocarcinoma
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Experimental dose: modified XELOX + sintilimab|DRUG: Standard dose: standard XELOX + sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Ciprofloxacin Versus Observation for Men With Elevated Prostate Specific Antigen (PSA)
Status: TERMINATED
Conditions: Elevated Prostate Specific Antigen
Interventions: DRUG: Ciprofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cabozantinib Plus Docetaxel and Prednisone for Advanced Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: Cabozantinib|DRUG: Docetaxel|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Iressa + Irradiation Followed by Chemo in NSCLC
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Gefitinib|PROCEDURE: Radiation therapy|DRUG: Cisplatin|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ViCToRy: Vorasidenib in Combination With Tumor Specific Peptide Vaccine for Recurrent IDH1 Mutant Lower Grade Gliomas
Status: NOT_YET_RECRUITING
Conditions: Low Grade Glioma of Brain
Interventions: DRUG: PEPIDH1M vaccine + vorasidenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post Intensive Care Unit Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation|Critical Illness
Interventions: DEVICE: Implantable ECG holter device (Biomonitor3, Biotronik)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Development of a New Tool for Dyspnea Measurement in Chronic Respiratory Diseases
Status: COMPLETED
Conditions: COPD (With - Without Rehabilitation)|Diffuse Interstitial Lung Diseases|Pulmonary Arterial Hypertension Primary or Secondary (Post Embolic .....)|Cystic Fibrosis of the Adult
Interventions: OTHER: Cross sectional psychometric evaluation of a self-administered dyspnea questionnaire.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Erector Spinae Plane Blockade in Pediatric Scoliosis Surgery Patients
Status: RECRUITING
Conditions: Scoliosis; Juvenile|Scoliosis; Adolescence
Interventions: PROCEDURE: Erector Spinae Plane Blockade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sharp Versus Blunt Uterine Incision Expansion
Status: UNKNOWN
Conditions: Cesarean Section Complications
Interventions: PROCEDURE: blunt uterine incision expansion|PROCEDURE: sharp uterine incision expansion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Rucaparib in Patients With Locally Advanced or Metastatic Urothelial Carcinoma
Status: TERMINATED
Conditions: Bladder Cancer|Urothelial Carcinoma|Metastatic Urothelial Carcinoma|Renal Pelvis Carcinoma|Ureter Carcinoma|Urinary Bladder Carcinoma|Urethra Carcinoma|Muscle Invasive Bladder Cancer
Interventions: DRUG: Rucaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone, Elotuzumab, and Pomalidomide in Treating Patients With Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Refractory Plasma Cell Myeloma
Interventions: DRUG: Dexamethasone|BIOLOGICAL: Elotuzumab|DRUG: Pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-inflammatory Drugs and Serum Prostate-Specific Antigen Test
Status: RECRUITING
Conditions: Prostate Cancer|Prostate Inflammation|PSA
Interventions: DRUG: Ibuprofen or Naproxen|DIAGNOSTIC_TEST: PSA test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Fat Versus Protein Sparing Diet for Weight Loss & Impact on Biomarkers Associated With Breast Cancer Risk
Status: COMPLETED
Conditions: Breast Cancer|Weight Loss
Interventions: BEHAVIORAL: Low Fat Diet plus exercise|BEHAVIORAL: Low Carbohydrate diet + Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Metformin and Sitagliptin Therapy for Adult Patients With Type 2 Diabetes Admitted to the General Medical Unit
Status: WITHDRAWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: metformin and sitagliptin|DRUG: insulin glargine and insulin lispro|DRUG: metformin and sitagliptin|DRUG: insulin glargine and insulin lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Encouraging Patient-Centered Communication in Clinical Video Telehealth Visits
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: BEHAVIORAL: Pamphlet|BEHAVIORAL: Video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study Evaluating Effexor® (Venlafaxine) in Achieving Response and Maintaining Remission
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Effexor® (Venlafaxine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dry Needling for Sub Acromial Pain Syndrome
Status: COMPLETED
Conditions: Subacromial Impingement Syndrome
Interventions: PROCEDURE: Standard Physical Therapy Treatment|PROCEDURE: Dry Needling|PROCEDURE: Sham Dry Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Everolimus+EC-MPS After Early CNI Elimination vs EC-MPS +Tacrolimus in Renal Transplant Recipients
Status: COMPLETED
Conditions: Chronic Renal Failure
Interventions: DRUG: Everolimus|DRUG: Tacrolimus (FK506)|DRUG: Basiliximab|DRUG: Enteric Coated Mycophenolate Sodium (EC-MPS)|DRUG: Corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Assessing PTI-428 Safety, Tolerability, Pharmacokinetics and Effect in Subjects With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: PTI-428|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab and Ipilimumab in Treating Patients With Metastatic Uveal Melanoma
Status: COMPLETED
Conditions: Metastatic Uveal Melanoma|Stage IV Uveal Melanoma AJCC v7
Interventions: BIOLOGICAL: Ipilimumab|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin and Esomeprazole For Preterm Pre-eclampsia
Status: NOT_YET_RECRUITING
Conditions: Preeclampsia Severe|Preeclampsia Second Trimester|Preterm Birth Complication
Interventions: DRUG: Esomeprazole 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immediate Loading With Provisional Prosthetic Restoration by Means of One Abutment at One Time and Temporary Abutment
Status: ENROLLING_BY_INVITATION
Conditions: Bone Loss in Jaw
Interventions: OTHER: immediate loading of implants
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: GMA-TulipTM, i-gelTM and the LMA-SupremeTM (LMA-S) Devices in Airway Management
Status: RECRUITING
Conditions: Anesthesia
Interventions: DEVICE: LMA supreme group|DEVICE: I-gel group|DEVICE: GMA-Tulip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First in Human, Dose Escalation Study to Evaluate the Safety and Tolerability of BBP-671 in Healthy Volunteers and Patients With Propionic Acidemia or Methylmalonic Acidemia
Status: TERMINATED
Conditions: Healthy Volunteers|Propionic Acidemia|Methylmalonic Acidemia|Organic Acidemia
Interventions: DRUG: BBP-671|DRUG: Placebo|DRUG: BBP-671
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Azithromycin Prophylaxis for Acute Chest Syndrome in Sickle Cell Disease
Status: WITHDRAWN
Conditions: Sickle Cell Disease|Acute Chest Syndrome
Interventions: DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Safety and Immunogenicity of BVRS-GamVac
Status: UNKNOWN
Conditions: MERS (Middle East Respiratory Syndrome)|MERS
Interventions: BIOLOGICAL: BVRS-GamVac|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety and Effectiveness Study of a Closed Loop System Maintaining Patients' Glucose Levels During an Overnight Period
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: Closed Loop Procedure (Medtronic)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Safety and Immunogenicity of Rabies Pre Exposure Prophylaxis Regimen Between Gvt of India Approved and WHO Approved.
Status: RECRUITING
Conditions: Vaccine Reaction
Interventions: BIOLOGICAL: Regimen 1|BIOLOGICAL: Regimen 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of Green Tea Extract (Polyphenon E®)in Ulcerative Colitis
Status: COMPLETED
Conditions: Mild to Moderately Active Ulcerative Colitis
Interventions: DRUG: Polyphenon E®|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Ocoxin®-Viusid® in Advanced Stomach Cancer and Gastric Esophagogastric Junction
Status: COMPLETED
Conditions: Stomach Neoplasm|Gastrointestinal Neoplasms|Digestive System Neoplasm|Esophageal Neoplasms|Head and Neck Neoplasms|Gastrointestinal Disease|Digestive System Disease|Esophageal Diseases|Stomach Diseases|Esophagogastric Junction Disorder
Interventions: DIETARY_SUPPLEMENT: Ocoxin-Viusid®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Omega-3 Supplement and Health Markers
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Fish oil + wild orange essential oil supplement|DIETARY_SUPPLEMENT: Fish oil supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Prospective Study in Adults Evaluating Safety & Efficacy of NVD003 for Bone Reconstruction to Treat Lower Limb Nonunion
Status: ACTIVE_NOT_RECRUITING
Conditions: Recalcitrant Lower Limb Nonunion
Interventions: OTHER: NVD003
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Study to Assess the Rate of Failure of an Enbrel® (Etanercept) SureClick™ Auto-injector in Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: irinotecan|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long-Term Study of the Safety and Tolerability of Repeated Administration of CEP-33457 in Participants With Systemic Lupus Erythematosus
Status: TERMINATED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: CEP-33457
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thiamine as a Renal Protective Agent in Septic Shock
Status: COMPLETED
Conditions: Sepsis|Kidney Injury|Thiamine Deficiency
Interventions: DRUG: Thiamine Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety, Tolerability and Pharmacokinetics Characteristics of HPP737 in Healthy Volunteers
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: HPP737 or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Days in Motion: A Planning Intervention Study With Couples to Enhance Daily Physical Activity
Status: COMPLETED
Conditions: Health Behavior|Physical Activity|Couples
Interventions: BEHAVIORAL: Dyadic planning intervention|BEHAVIORAL: Individual planning intervention|BEHAVIORAL: General motivational treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Early Post-Operative Water Exposure on Complications of Cutaneous Surgeries
Status: COMPLETED
Conditions: Surgical Wound Infection
Interventions: BEHAVIORAL: Early Water Exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Bevacizumab and Ziv-Aflibercept Administration in PDR Subjects Undergoing PPV
Status: COMPLETED
Conditions: Diabetic Retinopathy
Interventions: DRUG: Intravitreal bevacizumab or intravitreal ziv-aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of Progenta (CDB-4124) in Pre-menopausal Women With Symptomatic Leiomyomata
Status: COMPLETED
Conditions: Uterine Leiomyomata
Interventions: DRUG: Progenta|DRUG: Progenta|DRUG: Progenta|DRUG: Lucron Depot|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety of a New Inserter Device for Paragard® (Intrauterine Copper Contraceptive)
Status: COMPLETED
Conditions: Contraception
Interventions: COMBINATION_PRODUCT: Paragard® T380A Intrauterine Copper Contraceptive with New Inserter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Abdominal Trunk Function After Surgical Repair of Abdominal Rectus Muscle Diastasis
Status: COMPLETED
Conditions: Rectus Abdominus; Diastasis, Complicating Delivery
Interventions: PROCEDURE: Surgical repair of the diastasis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Gastroesophageal Reflux in Scleroderma Pulmonary Fibrosis
Status: UNKNOWN
Conditions: Interstitial Lung Disease|Systemic Sclerosis|Gastroesophageal Reflux
Interventions: OTHER: Gastro-esophageal reflux
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of a Self-care Intervention on Depression in People With Age-related Macular Degeneration or Diabetic Retinopathy
Status: COMPLETED
Conditions: Depression|Age-related Macular Degeneration
Interventions: BEHAVIORAL: Self-Care Tools
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction Study of Colchicine and Azithromycin
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Colchicine|DRUG: Azithromycin|DRUG: Colchicine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mindfulness-based Therapy Versus Relaxation in Prevention of Burnout in Medical Students
Status: UNKNOWN
Conditions: Burnout|Emotional Disturbances|Depression
Interventions: OTHER: Mindfulness Based Stress Reduction|OTHER: Relaxation group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tight Control of Disease Activity Among Patients With RA Based on a Systematic Telemedicine Treatment Strategy
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BEHAVIORAL: Disease control, Telemedicine, doctor|BEHAVIORAL: Disease control, Telemedicine, nurse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Pharmacokinetic and Efficacy Study of Amonafide L-malate (AS1413) in Combination With Cytarabine in Patients With Acute Myeloid Leukemia (AML)
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Amonafide + cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Olfaction and Inflammation in Chronic Rhinosinusitis With Nasal Polyps
Status: TERMINATED
Conditions: Nasal Polyps|Chronic Rhinosinusitis With Nasal Polyps|Olfaction Disorders
Interventions: DIAGNOSTIC_TEST: Sniffin Stick Test|OTHER: numerical evaluation scale for olfaction|OTHER: numerical evaluation scale for nasal obstruction|OTHER: nasal outcome test|BIOLOGICAL: dosage of 17 cytokines
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Use of AVL-3288 to Potentiate the Attention-Enhancing Effects of Low-Dose Nicotine
Status: WITHDRAWN
Conditions: Cognitive Change
Interventions: DRUG: Placebo|DRUG: Nicotine|DRUG: AVL-3288|DRUG: Nicotine + AVL-3288
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of an Early Nutrition Program on Promoting Breastfeeding and Optimizing Infant Growth and Diet Quality
Status: UNKNOWN
Conditions: Breastfeeding|Infant Development
Interventions: OTHER: Nutrition education program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Assess the Efficacy and Safety of Sitagliptin Added to the Regimen of Patients With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin (0431-189)
Status: COMPLETED
Conditions: Diabetes Mellitus, Non-Insulin-Dependent
Interventions: DRUG: sitagliptin phosphate|DRUG: Comparator: metformin|DRUG: Comparator: metformin|DRUG: Comparator: Antidiabetic Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polyunsaturated Fatty Acids in Patients With NAFLD.
Status: COMPLETED
Conditions: NAFLD
Interventions: DIETARY_SUPPLEMENT: Maxicor|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effectiveness of Yoga and Exercise in Female Patients With Fibromyalgia Syndrome
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: OTHER: aerobic|OTHER: resistant|OTHER: yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Six-Month, Open-Label, Crossover Study Of the Maintenance Of Serum Testosterone And PSA Suppression After Switching Between Lupron 22.5 Mg And Eligard 22.5 Mg Or Zoladex 10.8 Mg And Eligard 22.5 Mg In Patients With Advanced Prostate Cancer
Status: COMPLETED
Conditions: Cancer of Prostate
Interventions: DRUG: leuprolide acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study of Abatacept in Chinese Patients With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate
Status: UNKNOWN
Conditions: Rheumatoid Arthritis (RA)
Interventions: DRUG: Subcutaneous(SC) Abatacept|OTHER: Placebo|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Pharmacokinetics of Tacrolimus Prolonged-release (PR) Capsules and Advagraf® PR Capsules in Stable Kidney Transplant Patients.
Status: WITHDRAWN
Conditions: Kidney Transplant
Interventions: DRUG: Advagraf®|DRUG: Generic tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: AM-101 in the Treatment of Acute Tinnitus 3
Status: COMPLETED
Conditions: Tinnitus
Interventions: DRUG: AM-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Blood Management for Massive Obstetric Hemorrhage
Status: COMPLETED
Conditions: Post Partum Hemorrhage|Fibrinogenolysis; Hemorrhage|Fibrinogen; Deficiency, Acquired|Massive Hemorrhage|Transfusion Related Complication
Interventions: DIAGNOSTIC_TEST: Thromboelastometry|DIAGNOSTIC_TEST: Standard Coagulation Test|DRUG: Fibrinogen Concentrate Human|DRUG: Prothrombin Complex Concentrates|OTHER: Platelets|OTHER: Red Blood Cells|OTHER: Fresh Frozen Plasma|OTHER: cryoprecipitates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation Study of an Advanced Blood Pressure Monitor
Status: COMPLETED
Conditions: Atrial Fibrillation|Hypertension|Valvular Heart Disease
Interventions: DIAGNOSTIC_TEST: BP measurement|DIAGNOSTIC_TEST: AF detection|DIAGNOSTIC_TEST: VHD detection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: State Representation in Early Psychosis - Project 4
Status: RECRUITING
Conditions: Psychosis|Schizophrenia|Schizophrenia Spectrum and Other Psychotic Disorders|Schizoaffective Disorder
Interventions: DEVICE: Computerized Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Radiation Therapy + Combination Chemotherapy as 1st-Line Therapy for Patients With Inoperable Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: cisplatin|DRUG: 5-FU|DRUG: oxaliplatin|RADIATION: radiation therapy|DRUG: Folinic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Frontal and Parietal Contributions to Proprioception and Motor Skill Learning
Status: RECRUITING
Conditions: Basic Science
Interventions: OTHER: Theta burst transcranial magnetic stimulation|OTHER: Sham theta burst transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial to Evaluate the Safety and Efficacy of the Combination of the Oncolytic Immunotherapy Pexa-Vec With the PD-1 Receptor Blocking Antibody Nivolumab in the First-line Treatment of Advanced Hepatocellular Carcinoma (HCC)
Status: TERMINATED
Conditions: Hepatocellular Carcinoma (HCC)
Interventions: BIOLOGICAL: Pexastimogene Devacirepvec (Pexa Vec)|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Acute Migraine Headache in Children
Status: COMPLETED
Conditions: Migrainous Headache
Interventions: DRUG: Metoclopramide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Practice Effects and Amyloid Imaging Using 18F-PIB or Flutemetamol PET and FDG-PET
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: 18F-Flutemetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Transarterial Chemoembolization Prior to Transplantation for Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: OTHER: Intra-arterial administration of DC BeadsR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tinnitus Treatment With Piribedil Guided by Acoustic Otoemissions and Electrocochleography
Status: COMPLETED
Conditions: Tinnitus
Interventions: DRUG: piribedil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy and Safety of Highly Purified Urofollitropin for Ovulation Induction in Chinese Females
Status: COMPLETED
Conditions: Anovulation
Interventions: DRUG: Highly Purified Urofollitropin|DRUG: Recombinant Human Follitropin Alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of SKI-O-703 in Healthy Volunteers
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: SKI-O-703 capsule|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ECMO for Critically Ill Patients With Respiratory Failure and/or Circulatory Failure
Status: RECRUITING
Conditions: Severe Acute Respiratory Distress Syndrome|Refractory Hypoxemia
Interventions: DEVICE: Extra Corporeal Membrane Oxygenator (ECMO)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Selection of Immunosuppression in Kidney Transplant Recipients Depending on Pre-transplant Donor-specific T-cell Reactivity.
Status: COMPLETED
Conditions: Disorder Related to Renal Transplantation
Interventions: DRUG: PRE-TRANSPLANT (PRE=before)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of Daclatasvir Tablets and Bioavailability Studies of Daclatasvir and Asunaprevir
Status: COMPLETED
Conditions: Hepatitis C Infection
Interventions: DRUG: Daclatasvir|DRUG: Daclatasvir|DRUG: Asunaprevir|DRUG: Daclatasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Linperlisib Plus Obinutuzumab and Venetoclax for Relapsed and Refractory Blastoid Variant of Mantle Cell Lymphoma.
Status: NOT_YET_RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Linperlisib in combination with Obinutuzumab and Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Acupuncture for Chronic Migraine
Status: COMPLETED
Conditions: Chronic Migraine
Interventions: DEVICE: Laser Acupuncture|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prevention of Stimulant-Induced Euphoria With an Opioid Receptor Antagonist
Status: COMPLETED
Conditions: ADHD|Stimulant-Induced Euphoria
Interventions: DRUG: SODAS MPH|DRUG: Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Events in GnRH Agonist vs. Antagonist
Status: UNKNOWN
Conditions: Hormone Sensitive Prostate Cancer|Prostate Cancer|Cardiac Event
Interventions: DRUG: Degarelix|DRUG: GnRH agonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Transcutaneous Acupoint Electrical Stimulation on Postoperative HRV and Hs-cTnT of Elderly With CHD
Status: COMPLETED
Conditions: Coronary Artery Disease|Anesthesia
Interventions: PROCEDURE: transcutaneous acupoint electrical stimulation|PROCEDURE: sham transcutaneous acupoint electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Immunization Safety Assessment (CISA) Project: Pilot Study to Assess the Effect of Prophylactic Antipyretics on Immune Responses and Fever After IIV
Status: COMPLETED
Conditions: Fever
Interventions: OTHER: Acetaminophen|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Blood Flow Regulation and Neuromuscular Function Post-Stroke
Status: RECRUITING
Conditions: Stroke
Interventions: PROCEDURE: Ischemic Conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Gabapentin for Taxane-Induced Arthralgia and Myalgia Syndrome in Breast Cancer Patients Undergoing Adjuvant Chemotherapy
Status: UNKNOWN
Conditions: Invasive Breast Cancer|Chemotherapeutic Toxicity|Myalgia|Arthralgia
Interventions: DRUG: Gabapentin 300mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sapanisertib and Nivolumab for the Treatment of Stage I-IV Non-small Cell Lung Cancer in Patients Who Have Progressed on Prior PD-1/PD-L1 Inhibitor Therapy, I-OVERCOME Study
Status: WITHDRAWN
Conditions: Lung Non-Small Cell Carcinoma|Recurrent Lung Non-Small Cell Carcinoma|Stage I Lung Cancer AJCC v8|Stage II Lung Cancer AJCC v8|Stage IIA Lung Cancer AJCC v8|Stage IIB Lung Cancer AJCC v8|Stage III Lung Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|Stage IIIC Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: BIOLOGICAL: Nivolumab|DRUG: Sapanisertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Electromyographic Activity in Aligner Treatment of Adult Patients With and Without Nocturnal Bruxism
Status: RECRUITING
Conditions: Sleep Bruxism|Masseter Muscle Hypertrophy|Grinding Teeth
Interventions: DEVICE: Bruxoff ®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: International Clinical Trial to Evaluate Efficacy and Safety of Multiple Subcutaneous Injections of BCD-085 in Various Doses in Patients With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: BCD-085|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Research for Papillomavirus as the Examination of Orientation in the Organized Screening of the Cervical Cancer
Status: COMPLETED
Conditions: Research Human Papillomavirus ( HPV) by Vaginal Auto-takings ( APV) and Urinary Test
Interventions: OTHER: vaginal auto-takings and urinary test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Whole-course Immunonutrition Combined With Chemoradiotherapy±ICIs for Local Advanced Patients With Inoperable Esophageal Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma|Chemoradiotherapy|Immunonutrition|Inoperable
Interventions: DIETARY_SUPPLEMENT: Whole-course Immunonutrition Combined With Chemoradiotherapy±ICIs
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Theta tACS During Working Memory Training: A Pilot Study of the Effects on Negative Symptoms of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Negative Symptoms|Working Memory Training|Psychosocial Impairment|Autonomic Imbalance|EEG
Interventions: DEVICE: Theta tACS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of REGN4659 in Combination With Cemiplimab in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: REGN4659|DRUG: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fixed Dose Combination of Bisoprolol and Amlodipine in the Treatment of Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Bisoprolol/Amlodipine (Bisoprolol failed group)|DRUG: Bisoprolol/Amlodipine (Amlodipine failed group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT