pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study to Develop a Kinetic Model for FDG and Me4FDG in Kidneys of Type 2 Diabetic Patients
Status: UNKNOWN
Conditions: Type2 Diabetes Mellitus
Interventions: BEHAVIORAL: alpha-Methyl-4-deoxy-4-[(18)F]fluoro-D-glucopyranoside
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immunogenicity，Safety and Cross - Immune Response With Mutant Strains of a Third Dose of an Inactivated COVID-19 Vaccine
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: Inactivated COVID-19 Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety And Efficacy Study Of Intravenous (IV) Administration Of Elezanumab To Assess Change In Upper Extremity Motor Score (UEMS) In Adult Participants With Acute Traumatic Cervical Spinal Cord Injury (SCI)
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Cord Injury (SCI)
Interventions: DRUG: Elezanumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cell-free DNA Methylation for Endometrial Cancer
Status: UNKNOWN
Conditions: Endometrial Cancer|Liquid Biopsy|DNA Methylation|Cervical Cytology|Diagnostic Accuracy|Training Set|Validation Set
Interventions: DIAGNOSTIC_TEST: DNA methylation testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intracoronary Autologous Stem Cell Transplantation in ST Elevation Myocardial Infarction: TRACIA STUDY.
Status: UNKNOWN
Conditions: Acute Myocardial Infarction
Interventions: GENETIC: Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy of a Fixed-dose Regimen of Cariprazine Compared to Placebo for Treatment of the Depressive Episode in Participants With Bipolar I Disorder
Status: COMPLETED
Conditions: Bipolar Disorder|Depression
Interventions: DRUG: Cariprazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Follicular Fluid Markers and Reproductive Outcomes in IVF
Status: RECRUITING
Conditions: IVF|Infertility
Interventions: PROCEDURE: Natural cycle In Vitro Fertilisation (IVF)|DIAGNOSTIC_TEST: Blood samples for analysis|DIAGNOSTIC_TEST: Follicular fluid for analysis|DIAGNOSTIC_TEST: Sperm samples for analysis|PROCEDURE: Conventional In Vitro Fertilisation (IVF)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of Loncastuximab Tesirine in High Risk Diffuse Large B-cell Lymphoma Post Transplant
Status: WITHDRAWN
Conditions: Relapsed Diffuse Large B-cell Lymphoma
Interventions: DRUG: loncastuximab tesirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Pertuzumab in Combination With Trastuzumab (Herceptin) and a Taxane in First-Line Treatment in Participants With Human Epidermal Growth Factor 2 (HER2)-Positive Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Docetaxel|DRUG: Nab-paclitaxel|DRUG: Paclitaxel|DRUG: Pertuzumab|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Zoledronic Acid in Modic Changes-related Low Back Pain (LBP)
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: Zoledronic acid vs. placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Zinc Intake From Enriched Water and Other Dietary Sources in Kisumu, Kenya
Status: COMPLETED
Conditions: Zinc Deficiency
Interventions: DEVICE: LSF-filtering device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Multicomponent Telerehabilitation to Engage Veterans in Effective Self-Management of Complex Health Conditions
Status: RECRUITING
Conditions: Multimorbidity|Physical Deconditioning
Interventions: BEHAVIORAL: Motivational Interviewing Techniques|OTHER: Physical Therapy Interventions|OTHER: Education|OTHER: Health Status Updates|OTHER: Physical Therapy Consult
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Action Video Games and Stroboscopic Glasses on Dynamic Visual Acuity.
Status: NOT_YET_RECRUITING
Conditions: Visual Acuity
Interventions: DEVICE: Stroboscopic Glasses|DEVICE: Action Video Game
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pulsed Electromagnetic Field (PEMF) Therapy for Post-operative Pain Following Orthopedic Surgery
Status: RECRUITING
Conditions: Knee Injuries|Shoulder Injuries|Pain, Postoperative
Interventions: DEVICE: Endonovo SofPulse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combined Robotic Training and tDCS in Chronic SCI
Status: UNKNOWN
Conditions: Spinal Cord Injuries|Tetraplegia
Interventions: OTHER: transcranial direct current stimulation|OTHER: sham transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maternal alpha1 Antitrypsin as a Marker of Intrauterine Growth Restriction in Pre-eclamptic Women
Status: NOT_YET_RECRUITING
Conditions: alpha1 Anti-trypsin|Pre-Eclampsia|Intrauterine Growth Restriction
Interventions: DIAGNOSTIC_TEST: Alpha1 -Antitrypsin level
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Hepatic Protection During Living-donor Liver Transplantation
Status: COMPLETED
Conditions: End Stage Liver Disease
Interventions: DRUG: Desflurane balanced anesthesia|DRUG: Propofol total intravenous anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of Subcutaneous Belimumab and Intravenous Rituximab Co-administration in Subjects With Primary Sjogren's Syndrome
Status: COMPLETED
Conditions: Sjogren's Syndrome
Interventions: DRUG: Belimumab|DRUG: Rituximab|DRUG: Placebo belimumab|DRUG: Placebo rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Etafilcon A With Ketotifen
Status: COMPLETED
Conditions: Visual Acuity
Interventions: COMBINATION_PRODUCT: etafilcon A with ketotifen|DEVICE: 1-Day ACUVUE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Telbivudine Versus Lamivudine for Maintenance Therapy of Patients With Chronic Hepatitis B and Negative HBV Viral Load After 6 Month of Treatment With Telbivudine
Status: TERMINATED
Conditions: Hepatitis, Chronic
Interventions: DRUG: Lamivudine|DRUG: Telbivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence,Natural History,Prognosis Factor,QualityofLife,Health Care Consumption and Social Consequences of Symptomatic Knee and Hip Osteoarthritis in France
Status: UNKNOWN
Conditions: Hip Osteoarthritis|Knee Osteoarthritis
Interventions: PROCEDURE: X-rays|BIOLOGICAL: biological samples|OTHER: medical information about osteoarthritis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Randomized, Prospective Comparison of Two Femoral Reaming Systems
Status: COMPLETED
Conditions: Femur Fracture
Interventions: DEVICE: Synthes Reamer-Irrigator-Aspirator (RIA)|DEVICE: Zimmer Sentinel Reamer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Continuous vs Intermittent Aerobic Exercise on Glycemic Control in a Barbadian Population With Type 2 Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Single Bout ('S')|BEHAVIORAL: Multiple Bout ('M')
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genome-wide Pharmacogenetic Candidate Gene Single Nucleotide Polymorphism (SNP) Array-based Approach to Predict Chemoresponse and Survival in Patients With Acute Myeloid Leukemia With Normal Karyotype
Status: UNKNOWN
Conditions: Myeloid Leukemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase III Randomized Trial of Metformin vs Placebo in Early Stage Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: metformin hydrochloride|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Plasma Lipoprotein Apheresis Systems DIAMED and MONET vs. the Whole Blood Apheresis System DALI
Status: COMPLETED
Conditions: Hypercholesterolemia, Familial|Dyslipidemias|Cardiovascular Diseases
Interventions: DEVICE: Lipoprotein Apheresis MONET and DALI|DEVICE: Lipoprotein Apheresis DIAMED and DALI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Daratumumab Combined With Bortezomib and Dexamethasone in Mayo 04 Stage III Light Chain Amyloidosis
Status: UNKNOWN
Conditions: Amyloidosis; Systemic
Interventions: DRUG: Daratumumab|DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Evaluate the Restore Orthobiologic Implant in Rotator Cuff Tear Repair
Status: COMPLETED
Conditions: Arm Injuries
Interventions: DEVICE: RESTORE SIS Patch|PROCEDURE: Rotator cuff repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study to Further the Development of Lung Cancer-based Precision Medicine
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer|Head and Neck Cancer
Interventions: OTHER: Fresh tissue biopsy|OTHER: Blood/Urine Sample Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Rituximab and/or Lenalidomide in Treating Patients With Follicular Non-Hodgkin's Lymphoma That is Not Refractory to Rituximab
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carotid B-mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrapib/Atorvastatin to Atorvastatin.
Status: TERMINATED
Conditions: Mixed Hyperlipidemia
Interventions: DRUG: torcetrapib/atorvastatin|DRUG: atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Autologous Muscle Derived Cells for Female Urinary Sphincter Repair
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: OTHER: Placebo|BIOLOGICAL: Iltamiocel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of a Cancer Vaccine to Treat Patients With Advanced Stage Ovarian, Fallopian or Peritoneal Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Cancer
Interventions: BIOLOGICAL: DPX-Survivac|DRUG: low dose cyclophosphamide (oral)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Balance-Enhancing Effects of Insole Hardness and Thickness for Older Adult Footwear
Status: COMPLETED
Conditions: Accidental Falls
Interventions: DEVICE: Modified Insole|DEVICE: Non-Modified Insole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Between Continuous Infusion and Intermittent Bolus Injection of Propofol for Deep Sedation During ERCP
Status: UNKNOWN
Conditions: Biliary Tract Diseases|Pancreatic Diseases
Interventions: PROCEDURE: Continuous infusion of propofol|PROCEDURE: Intermittent bolus injection of propofol|DRUG: Midazolam|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Safety and Tolerability of GemRIS 225 mg in Subjects With Muscle-Invasive Bladder Cancer
Status: COMPLETED
Conditions: Urinary Bladder Cancer
Interventions: DRUG: Gemcitabine-Releasing Intravesical System (GemRIS)/TAR-200
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Followed by Surgery and Intraperitoneal Chemotherapy in Treating Patients With Locally Advanced Stomach Cancer
Status: COMPLETED
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: DRUG: cisplatin|DRUG: docetaxel|DRUG: floxuridine|DRUG: fluorouracil|DRUG: leucovorin calcium|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Shortened Time Interval to Postpartum Visit in Improving Postpartum Attendance
Status: COMPLETED
Conditions: Pregnancy Related|Contraception|Contraception Behavior|Contraception Use
Interventions: BEHAVIORAL: Postpartum Visit 3-4 Weeks|BEHAVIORAL: Postpartum Visit 6-8 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Pilot Study to Evaluate the Effect of a Probiotic Mixture in Acne
Status: COMPLETED
Conditions: Acne|Acne Vulgaris
Interventions: DIETARY_SUPPLEMENT: Probiotic Bths-003|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: VR vs. Conventional Cycling Exercise for Geriatric Inpatient Physical Activation
Status: UNKNOWN
Conditions: Inactivity, Physical|Treatment Adherence and Compliance|Hospital Acquired Condition|Sarcopenia
Interventions: DEVICE: Virtual reality cycling exercise|BEHAVIORAL: Unsupervised stationary cycling exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Exercise Training in Children With Corrective Cardiac Surgeries
Status: COMPLETED
Conditions: Quality of Life|Congenital Heart Disease|Heart; Surgery, Heart, Functional Disturbance as Result
Interventions: OTHER: INTERVENTION GROUP|OTHER: CONTROL GROUP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Significance of Retinal Emboli During Diagnostic and Therapeutic Cardiac Catheterization
Status: COMPLETED
Conditions: Cardiac Catheterization|Retina|Embolism
Interventions: PROCEDURE: diagnostic cardiac catheterization|PROCEDURE: therapeutic cardiac catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 18F-Fluciclovine PET/CT in Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma|Newly Diagnosed Multiple Myeloma (NDMM)|Relapsed and/or Refractory Multiple Myeloma (RRMM)
Interventions: DRUG: 18F-fluciclovine injection|PROCEDURE: 18F-FDG PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Smart Sleep Apnea Self-management Support Programme(4S) for Subjects With Sleep Apnea
Status: NOT_YET_RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: BEHAVIORAL: Smart Sleep Apnea Self-management Support Programme (4S)|BEHAVIORAL: General Hygiene Information (GH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Atu027 Plus Gemcitabine in Advanced or Metastatic Pancreatic Cancer (Atu027-I-02)
Status: COMPLETED
Conditions: Carcinoma, Pancreatic Ductal
Interventions: DRUG: Atu027 & gemcitabine in lead in safety period|DRUG: Atu027 & gemcitabine in treatment arm 1|DRUG: Atu027 & gemcitabine in treatment arm 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closed Versus Open Cells Stent for Acute Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction|Primary Percutaneous Coronary Intervention
Interventions: DEVICE: Open cells stent|DEVICE: Closed Cells Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Use of Deferasirox as Compared to Deferoxamine in Treating Cardiac Iron Overload
Status: COMPLETED
Conditions: Transfusional Iron Overload|Transfusional Hemosiderosis
Interventions: DRUG: Core Study: Deferasirox|DRUG: Core Study: Deferoxamine|DRUG: Extension: deferoxamine to deferasirox|DRUG: Extension: deferasirox to deferoxamine|DRUG: Deferasirox|DRUG: Deferoxamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eribulin Mesylate in Treating Patients With Recurrent or Refractory Osteosarcoma
Status: COMPLETED
Conditions: Recurrent Osteosarcoma
Interventions: DRUG: Eribulin Mesylate|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vasomotor Symptoms (VMS) Progesterone Study: Vasomotor Symptoms and Endothelial Function - Trial of Oral Micronized Progesterone
Status: UNKNOWN
Conditions: Menopause
Interventions: DRUG: Oral Micronized Progesterone (Prometrium®)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Oral Vorinostat Plus Oral Eltrombopag Support in Patients With Lymphoma (VEIL)
Status: TERMINATED
Conditions: Follicular Lymphoma|Marginal Zone Lymphoma|Mantle Cell Lymphoma
Interventions: DRUG: Eltrombopag and Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects Potato Protein on Rates of Myofibrillar Muscle Protein Synthesis in Young Women
Status: COMPLETED
Conditions: Muscle Protein Synthesis
Interventions: DIETARY_SUPPLEMENT: Protein|DIETARY_SUPPLEMENT: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Evaluating Antibody Response Of 13-Valent Pneumococcal Conjugate Vaccine (13vPnC) 24 Months After Toddler Dose.
Status: COMPLETED
Conditions: 13-valent Pneumococcal Vaccine|Immunization|Safety|Antibody Response
Interventions: BIOLOGICAL: 13-valent pneumococcal conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mesenteric SParIng Versus Central mesenterectomY in Ileocolic Resection for Terminal Ileitis in Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: PROCEDURE: Mesenteric sparing ileocolic resection|PROCEDURE: Central mesenterectomy ileocolic resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Irbesartan in Heart Failure With Preserved Systolic Function (I-Preserve)
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: DRUG: Irbesartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance and Stability of Different Types of Implant Supported Overdenture
Status: COMPLETED
Conditions: Complete Edentulism
Interventions: DEVICE: Osstell ( Osstell AB, Goteborg, Sweden).|DEVICE: periodontal probe (Vivacare, TPS, Vivadent, Schaan, Lichtenstein|OTHER: questionnaire for patient satisfaction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Sodium Intake on Calcium Retention in Girls
Status: COMPLETED
Conditions: Osteoporosis
Interventions: OTHER: Low Na diet (1.3 g/d)|OTHER: High sodium diet (3.8 g/d)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Trial to Evaluate Safety, Feasibility and Efficacy of the ReCET Procedure (EMINENT-2)
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: ReCET|DRUG: Semaglutide, 1.0 mg/mL|OTHER: Sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Evaluation of the VetChange Mobile App for Veterans With PTSD Who Engage in Problem Drinking
Status: UNKNOWN
Conditions: Alcohol Abuse|Post-Traumatic Stress Disorder
Interventions: BEHAVIORAL: VetChange|BEHAVIORAL: web-based drinking assessment and feedback tool (AFT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections)
Status: COMPLETED
Conditions: Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis
Interventions: DRUG: Ceftazidime - Avibactam ( CAZ-AVI)|DRUG: Doripenem|DRUG: Either switch to oral therapy: 500 mg of Ciprofloxacin (oral)|DRUG: or switch to oral therapy: 800 mg/160 mg of sulfamethoxazole/trimethoprim (oral)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Meal Composition on Postprandial Testosterone Concentration in Women With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: BEHAVIORAL: Meal Composition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BION-1301 in Adults With IgA Nephropathy
Status: RECRUITING
Conditions: IgA Nephropathy|Immunoglobulin A Nephropathy
Interventions: DRUG: BION-1301|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Listening to Surah Inshirah on Mental Health in Hemodialysis Patients.
Status: COMPLETED
Conditions: Hemodialysis Patients
Interventions: BEHAVIORAL: Surah Inshirah
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Relapsed Acute Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: sargramostim|DRUG: carmustine|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: etoposide|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Recombinant Human Growth Hormone During Rehabilitation From Traumatic Brain Injury.
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: DRUG: Recombinant human Growth Hormone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ibrutinib in Patients With CLL and Other Indolent B-cell Lymphomas Who Are Chronic Hepatitis B Virus Carriers or Occult Hepatitis B Virus Carriers
Status: UNKNOWN
Conditions: Chronic Lymphocytic Leukemia|Indolent B-cell Lymphomas|Chronic Hepatitis B|Lymphoma, Small Lymphocytic|Mantle-Cell Lymphoma|Waldenstrom's Macroglobulinaemia|Follicular Lymphoma
Interventions: DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of Short Fiber Reinforced Flowable Resin Composite Restorations 2y RCT
Status: UNKNOWN
Conditions: Decay, Dental|Caries Class II
Interventions: OTHER: Short fiber reinforced flowable resin composite restorations|OTHER: Conventional resin composite restoration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein
Status: COMPLETED
Conditions: Chronic Venous Insufficiency
Interventions: PROCEDURE: Ablation of the Incompetent Greater Saphenous Vein|DEVICE: ClosureFAST radiofrequency catheter|DEVICE: EVLT 980nm diode laser system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes of Mastoid Obliteration Canal Wall Down Tympanomastoidectomy in Cholesteatoma Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Cholesteatoma
Interventions: PROCEDURE: Canal wall down tympanomastoidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Lasmiditan (LY573144) in a Single Migraine Attack in Japanese Participants With Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Lasmiditan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Avelumab as Single Agent in Metastatic or Locally Advanced Urothelial Cancer in Patients Unfit for Cisplatin. The ARIES Study
Status: COMPLETED
Conditions: Metastatic or Locally Advanced PD-L1 Positive Urothelial Cancer
Interventions: DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Systematic Laryngoscopic Evaluation of Upper Airways in Ventilated ALS Patients in Portugal and in Norway
Status: UNKNOWN
Conditions: Amyotrophic Lateral Sclerosis
Interventions: OTHER: Transnasal Fiberoptic Laryngoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Two-fraction HDR Monotherapy for Localized Prostate Cancer
Status: NOT_YET_RECRUITING
Conditions: Prostate Adenocarcinoma|Localized Prostate Carcinoma
Interventions: RADIATION: High Dose Rate Monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fourth Dose of mRNA COVID-19 Vaccine in Residents of LTCFs
Status: UNKNOWN
Conditions: SARS-CoV2 Infection|Coronavirus Infection
Interventions: DRUG: mRNA- COVID-19|DRUG: Prevnar13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Propranolol Rescue of Prolonged Labor
Status: TERMINATED
Conditions: Pregnancy, Prolonged
Interventions: DRUG: Propranolol Hydrochloride|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Virtual Reality in Physical Therapy in Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DEVICE: Neuroproprioceptive "facilitation and inhibition" in virtual reality|OTHER: Neuroproprioceptive "facilitation and inhibition"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Vaccination Against COVID-19 in Patients Presenting a Neuromuscular Disease With Severe Amyotrophy
Status: COMPLETED
Conditions: Neuromuscular Diseases|COVID-19|Amyotrophy
Interventions: BIOLOGICAL: Blood sample for research of anti-xoprs netralizing anti spike|OTHER: Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Topical Ruxolitinib Evaluation in Atopic Dermatitis Study 1 (TRuE AD1) - An Efficacy and Safety Study of Ruxolitinib Cream in Adolescents and Adults With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Ruxolitinib Cream|DRUG: Vehicle Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of CDNF by Brain Infusion in Patients With Parkinson's Disease. Extension to HP-CD-CL-2002 Clinical Study
Status: COMPLETED
Conditions: Parkinson Disease|Movement Disorders|Neuro-Degenerative Disease|Nervous System Diseases|Brain Diseases
Interventions: DRUG: Cerebral Dopamine Neurotrophic Factor|DEVICE: Renishaw Drug Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Venetoclax in Combination With 5 Days Azacitidine in Untreated AML Patients, Not Eligible for Standard Induction Therapy
Status: RECRUITING
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: VEN+AZA-5
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EUS-guided Ethanol-lipiodol Ablation of Pancreatic Neuroendocrine Tumor: a Prospective Study
Status: UNKNOWN
Conditions: Efficacy|Safety|Feasibility
Interventions: PROCEDURE: EUS-guided ethanol-lipiodol mixture ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determining The Impact Of Distance Reiki On Patient Reported QOL And Immunity Among Multiple Myeloma Patients
Status: RECRUITING
Conditions: Multiple Myeloma|Autologous Stem Cell Transplant
Interventions: OTHER: Distance Reiki|OTHER: Sham distance Reiki
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Keppra and Clonidine in the Treatment of Tics
Status: COMPLETED
Conditions: Tic Disorders|Tourette Syndrome
Interventions: DRUG: Levetiracetam|DRUG: Clonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Look At Safety And Blood Concentrations After Multiple Doses Of PF-03382792 In Healthy Elderly Individuals
Status: WITHDRAWN
Conditions: Healthy
Interventions: DRUG: PF-03382792 0.5mg|DRUG: PF-03382792 1.5 mg|DRUG: PF-03382792 5 mg|DRUG: PF-03382792 15 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study to Assess Efficacy and Safety of M72/AS01E-4 Mycobacterium Tuberculosis (Mtb) Vaccine in Adolescents and Adults
Status: RECRUITING
Conditions: Tuberculosis
Interventions: BIOLOGICAL: M72/AS01E-4 Mycobacterium tuberculosis investigational vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Pharmacokinetics and Safety of BAY3427080 (NT-814) in Post-Menopausal Women With Vasomotor Symptoms
Status: COMPLETED
Conditions: Post-menopausal Vasomotor Symptoms
Interventions: DRUG: BAY3427080|DRUG: Placebo (for BAY3427080)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Immuno-bridging and Immunization Schedules Study of COVID-19 Vaccine (Vero Cell), Inactivated
Status: ACTIVE_NOT_RECRUITING
Conditions: Covid19
Interventions: BIOLOGICAL: 3-doses schedule 1 of COVID-19 Vaccine (Vero Cell), Inactivated|BIOLOGICAL: 3-doses schedule 2 of COVID-19 Vaccine (Vero Cell), Inactivated|BIOLOGICAL: 3-doses schedule 3 of COVID-19 Vaccine (Vero Cell), Inactivated|BIOLOGICAL: 2 doses of vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prolensa (Bromfenac) 0.07% QD vs. Ilevro (Nepafenac) 0.3% QD for Treatment of Ocular Inflammation Post Cataract Surgery
Status: COMPLETED
Conditions: Cataract|Retinal Edema|Inflammation
Interventions: DRUG: Prolensa (bromfenac 0.07%)|DRUG: Ilevro (nepafenac 0.3%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: IV Acetaminophen for Postoperative Pain After Pelvic Organ Prolapse Repair
Status: COMPLETED
Conditions: Pelvic Organ Prolapse
Interventions: DRUG: IV Acetaminophen|DRUG: IV normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Two Sets of Bladder-Filling Instructions in Treating Patients Undergoing Radiation Therapy For Prostate Cancer. ICORG 05-04
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: pre-procedural preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strain Analysis for Assessment of Myocardic Dysfunction During Orthotopic Liver Transplantation
Status: COMPLETED
Conditions: Myocardial Dysfunction|Liver Transplant; Complications
Interventions: PROCEDURE: Longitudinal strain obtained thanks to transesophageal ultrasound data recorded during liver transplantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Open-Label Tolerability and Exploratory Efficacy Study of Zonisamide for Dyskinesias in Parkinson's Disease
Status: SUSPENDED
Conditions: Parkinson Disease|Parkinsonism|Dyskinesias
Interventions: DRUG: Zonegran|DRUG: Zonegran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Establishing the Central and Peripheral Fatigue Indexes and VR Based Anti-fatigue Training Paradigm for Individuals With Parkinson Disease
Status: COMPLETED
Conditions: Parkinson's Disease (PD)
Interventions: PROCEDURE: Virtual Reality anti-fatigue ergo cycling training (Self-made)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: Filgrastim (G-CSF)|DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate|PROCEDURE: Peripheral Blood Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurodevelopmental Therapy for Spastic Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Spastic|Diplegia, Spastic
Interventions: OTHER: Neurodevelopmental therapy|OTHER: Routine physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mesalazine Treatment in IBS (The MIBS Study)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Mesalazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Correlation of MR Thermal Imaging to Actual Size of Ablation During Laser Ablation Therapy
Status: COMPLETED
Conditions: Advanced Cancer|Bone Metastases
Interventions: PROCEDURE: Laser Ablation|PROCEDURE: Magnetic Resonance Thermal Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnosis of Covert/Minimal Hepatic Encephalopathy by Means of Continuous Reaction Time Measurement
Status: COMPLETED
Conditions: Liver Cirrhosis|Hepatic Encephalopathy
Interventions: DRUG: Lactulose and rifaximin|DIETARY_SUPPLEMENT: Branched Chain amino acids|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Negative Pressure Wound Therapy in Healing Abdominal Incision in Obese Patients Undergoing Breast Reconstruction Surgery
Status: RECRUITING
Conditions: Body Mass Index Greater Than or Equal to 30|Malignant Breast Neoplasm|Mammoplasty Patient|Obesity
Interventions: PROCEDURE: Negative Pressure Wound Therapy|PROCEDURE: Wound Care Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate an Aflibercept (EYLEA®) Prefilled Syringe
Status: COMPLETED
Conditions: Chorioretinal Vascular Disease
Interventions: DRUG: Intravitreal Aflibercept Injection (IAI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Inflammatory and Metabolic Effect of High Fructose Intake
Status: COMPLETED
Conditions: Inflammatory Response|Metabolic Disturbance
Interventions: OTHER: Group fructose|OTHER: Group Sucrose|OTHER: Group Glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing Cefepime Versus Cefazolin Plus Ceftazidime for CAPD-associated Peritonitis
Status: COMPLETED
Conditions: Peritoneal Dialysis Associated Peritonitis
Interventions: DRUG: Cefepime|DRUG: Cefazolin plus Ceftazidime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of an Investigational Quadrivalent Meningococcal Conjugate Vaccine Administered in Children Aged 2 to 9 Years
Status: COMPLETED
Conditions: Meningitis|Meningococcal Meningitis|Meningococcal Infections
Interventions: BIOLOGICAL: Meningococcal Polysaccharide (Serogroups A, C, Y, and W) Tetanus Toxoid Conjugate|BIOLOGICAL: Meningococcal (Groups A, C, Y and W 135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Digital Educational Interventions on Parental HPV Knowledge and Attitude, and Their Children's Vaccination Rates
Status: COMPLETED
Conditions: Health Services Research
Interventions: BEHAVIORAL: Video education about HPV and HPV vaccine|BEHAVIORAL: Electronic reminder messages|BEHAVIORAL: Usual Information Service
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients
Status: RECRUITING
Conditions: Metastatic Breast Cancer|Brain Metastases
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ-88998377 for Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma
Status: RECRUITING
Conditions: Lymphoma, Non-Hodgkin|Refractory B-Cell NHL|Relapsed B-cell NHL
Interventions: DRUG: JNJ-88998377
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Efficacy of Tiotropium + Olodaterol (5/5 µg) Fixed Dose Combination (FDC) Over Tiotropium 5µg in Reducing Moderate to Severe Exacerbations in Patients With Severe to Very Severe Chronic Obstructive Pulmonary Disease.
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: olodaterol|DRUG: tiotropium|DRUG: tiotropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Simulated Comparison of Standard Versus Rotational Laryngeal Mask Airway Insertion in Novice Anaesthesiologists.
Status: COMPLETED
Conditions: Training Group, Sensitivity
Interventions: DEVICE: LMA insertion with standard technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Participant Centered Active Surveillance for Adverse Event Following Measles Immunization in Gedeo Zone, Ethiopia, 2022. A Multi-center Open-label Randomized Control Trial
Status: NOT_YET_RECRUITING
Conditions: Measles
Interventions: DEVICE: SMS, telephone interview or diary card
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Canagliflozin on C-peptide Clearance in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Canagliflozin 300 mg|DRUG: Placebo|DRUG: Somatostatin|DRUG: C-peptide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Thrombus Aspiration During Percutaneous Coronary Intervention in Acute Non-ST-elevation Myocardial Infarction Study
Status: UNKNOWN
Conditions: Non-ST-Elevation Myocardial Infarction
Interventions: PROCEDURE: Thrombus aspiration followed by stent implantation|PROCEDURE: conventional PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolism-Informed Care to Aid Alaska Native People to Quit Smoking (QUIT)
Status: NOT_YET_RECRUITING
Conditions: Smoking Cessation
Interventions: OTHER: Nicotine Metabolite Ratio
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Multiple Ascending Doses of MEDI6012 in Subjects With Stable Atherosclerotic Cardiovascular Disease
Status: COMPLETED
Conditions: Atherosclerosis|Cardiovascular Disease
Interventions: DRUG: MEDI6012 40 mg|DRUG: Placebo|DRUG: MEDI6012 120 mg|DRUG: MEDI6012 300 mg|DRUG: Placebo IV Push|DRUG: MEDI6012 IV Push
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Conditioning Electrical Stimulation to Improve Outcomes in Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: PROCEDURE: Conditioning electrical stimulation|PROCEDURE: Postoperative electrical stimulation|PROCEDURE: No electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Evaluation of Rasburicase in Patients With Leukemia and/or Lymphoma at High Risk of TLS
Status: COMPLETED
Conditions: Leukemia|Lymphoma|Tumor Lysis Syndrome
Interventions: DRUG: Rasburicase
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Vitality Project for Fatigued Female Cancer Survivors
Status: UNKNOWN
Conditions: Fatigue|Cancer Survivorship
Interventions: BEHAVIORAL: Qigong|BEHAVIORAL: Healthy Living (CHIP + Pre-Train)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT