pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effectiveness of Electrical Stimulation or Kinesio Taping on Recovery Disability in Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: OTHER: Kinesio taping|OTHER: Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Effects of Vitamin A and Vitamin D Supplementation on Treatment of Children With ADHD
Status: UNKNOWN
Conditions: ADHD
Interventions: DRUG: Placebos|DIETARY_SUPPLEMENT: vitamin AD|DIETARY_SUPPLEMENT: vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Combined Peripheral Nerve Block and Physiotherapy for CRPS
Status: NOT_YET_RECRUITING
Conditions: Complex Regional Pain Syndromes
Interventions: PROCEDURE: Axillary Brachial Plexus Block plus Physiotherapy|PROCEDURE: Physiotherapy alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Salsalate on Prandial-Induced Vascular Inflammation After Spinal Cord Injury (SCI)
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: DRUG: Salsalate 2grams twice a day for 30 days. Then Placebo for 30 days|DRUG: Placebo twice a day for 30 days. Then Salsalate 2gr BID for 30 days.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Lipid Biomarker Study in Men With Dyslipidemia After Simvastatin Treatment (Study MK-0000-140)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia, Dyslipidemia
Interventions: DRUG: Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Different Cycles of Capecitabine Usage in Esophageal Cancer Concurrent Chemoradiotherapy
Status: UNKNOWN
Conditions: Stage III Esophageal Squamous Cell Carcinoma|Stage II Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Capecitabine(Aibin)|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abuse Potential of Single Doses of Lorcaserin in Healthy Recreational Polydrug Users
Status: COMPLETED
Conditions: Drug Abuse|Healthy
Interventions: DRUG: Placebo|DRUG: Active Comparator #1|DRUG: Active Comparator #2|DRUG: Active Comparator #3|DRUG: Lorcaserin Dose #1|DRUG: Lorcaserin Dose #2|DRUG: Lorcaserin Dose #3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Exemestane, Letrozole, or Anastrozole in Treating Postmenopausal Women Who Are Undergoing Surgery for Stage II or Stage III Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: anastrozole|DRUG: exemestane|DRUG: letrozole|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Smartphone and Wearable Detected Atrial Arrhythmia in Older Adults Case Finding Study (Smart in OAC - AFNET 9)
Status: COMPLETED
Conditions: Atrial Arrhythmia
Interventions: DEVICE: Preventicus heartbeat app in combination with wearables
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Comparative Dissolution and Absorption Study of an Orodispersible Powder, Chewable Tablet and Soft Gel Capsule Vitamin D3 Supplementation
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Soft gelatin 200000 IU vitamin D3 capsule|DIETARY_SUPPLEMENT: Orodispersible (sachet) 200000 IU vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing Function and Pain After Total Knee Arthroplasty With Combined Femoral and Popliteal Nerve Block
Status: COMPLETED
Conditions: Total Knee Arthroplasty|Total Knee Replacement|Total Knee Replacement Surgery|Arthritis Knee|Rehabilitation
Interventions: PROCEDURE: Combined Femoral and Popliteal nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Valproic Acid With Temozolomide and Radiation Therapy to Treat Brain Tumors
Status: COMPLETED
Conditions: High Grade Gliomas|Brain Tumors
Interventions: PROCEDURE: adjuvant therapy|DRUG: Temozolomide|DRUG: Valproic Acid|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposome-Encapsulated Doxorubicin Citrate and Carboplatin in Treating Patients With Advanced or Metastatic Recurrent Endometrial Cancer
Status: UNKNOWN
Conditions: Endometrial Cancer
Interventions: DRUG: carboplatin|DRUG: liposome-encapsulated doxorubicin citrate|OTHER: laboratory biomarker analysis|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sensory Integration in Diplegic Cerebral Palsy
Status: COMPLETED
Conditions: Diplegic Cerebral Palsy
Interventions: OTHER: Sensory Integration Therapy Group|OTHER: Neurodevelopmental Treatment Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Bubble Continuous Positive Airway Pressure Compared to Nasal Prong Oxygen or Humidified High Flow in Children Under Five With Severe Pneumonia and Hypoxaemia
Status: COMPLETED
Conditions: Pneumonia|Hypoxaemia
Interventions: PROCEDURE: Bubble continuous positive airway pressure|PROCEDURE: Humidified high flow air / O2 mix at 2 l/kg/min|PROCEDURE: Standard O2 supplementation by nasal cannula at 0.5 - 2 l/min
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of the Individually Adjusted Therapy Scale (ATI) on the Addiction Severity
Status: UNKNOWN
Conditions: Addictive Behavior|Substance-Related Disorders
Interventions: PROCEDURE: Weekly assessment|PROCEDURE: Weekly assessment ajusted
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: EMPOWERYOU: Examining an Internet-based Prevention Program for Primary Caregivers
Status: RECRUITING
Conditions: Victimisation
Interventions: BEHAVIORAL: Basic modules|BEHAVIORAL: Basic modules and experimental condition "My coach"|BEHAVIORAL: Basic modules and experimental module "Who am I and where do I belong?"|BEHAVIORAL: Basic modules and experimental modules "Who am I and where do I belong?" and "My coach"|BEHAVIORAL: Basic modules and experimental module "You are safe here"|BEHAVIORAL: Basic modules and experimental modules "You are safe here" and "My coach"|BEHAVIORAL: Basic modules and experimental modules "You are safe here" and "Who am I and where do I belong?"|BEHAVIORAL: Basic modules and experimental modules "You are safe here", "Who am I and where do I belong?", and "My coach"|BEHAVIORAL: Basic modules and experimental module "Watch out!"|BEHAVIORAL: Basic modules and experimental modules "Watch out!" and "My coach"|BEHAVIORAL: Basic modules and experimental modules "Watch out!" and "Who am I and where do I belong?"|BEHAVIORAL: Basic modules and experimental modules "Watch out!", "Who am I and where do I belong?", and "My coach"|BEHAVIORAL: Basic modules and experimental modules "Watch out!" and "You are safe here"|BEHAVIORAL: Basic modules and experimental modules "Watch out!", "You are safe here", and "My coach"|BEHAVIORAL: Basic modules and experimental modules "Watch out!", "You are safe here", and "Who am I and where do I belong?"|BEHAVIORAL: Basic modules and experimental modules "Watch out!", "You are safe here", "Who am I and where do I belong?", and "My coach"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Performance of JOURNEY II CR and JOURNEY II BCS in TKA Populations
Status: WITHDRAWN
Conditions: Arthroplasty|Replacement|Knee
Interventions: DEVICE: JOURNEY II BCS Total Knee System|DEVICE: JOURNEY II CR Total Knee System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Doxorubicin and Docetaxel in HER2 Negative Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Neoplasm Metastasis
Interventions: DRUG: Non pegylated liposomal doxorubicin and docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention Trial of Nosocomial Infections in Neutropenic Prematures With G-CSF
Status: COMPLETED
Conditions: Neutropenia in Prematures
Interventions: DRUG: filgrastim|DRUG: dextrose 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Robot-assisted Intracorporeal Urinary Reconstruction
Status: UNKNOWN
Conditions: Urothelial Carcinoma|Cystectomy|Urinary Diversion|Complication of Surgical Procedure|Complication, Postoperative|Neobladder|Ileal Conduit|Robotic Surgical Procedures
Interventions: PROCEDURE: robot-assisted cystectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Single Versus Multiple Plastic Stents in Malignant Distal Bile Duct Obstruction
Status: TERMINATED
Conditions: Plastic Stent Occlusion
Interventions: DEVICE: Single plastic stent|DEVICE: Multiple plastic stents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Irreversible Electroporation and NK Immunotherapy for Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: NK cells|PROCEDURE: irreversible electroporation (IRE )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Thrombosis Prevention in Patients With CD
Status: UNKNOWN
Conditions: Cushing Disease|DVT|Pulmonary Embolism
Interventions: DRUG: LMWH/Rivaroxaban|DEVICE: IPC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Telmisartan by Ambulatory Blood Pressure Monitoring (ABPM) in Chinese Patients With Mild to Moderate Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Laparoscopic Ovarian Drilling on Ovarian Reserve in Patients With Anovulatory Polycystic Ovarian Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: PROCEDURE: Laparoscopic ovarian drilling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemoradiation With Bevacizumab for Chinese Rectal Cancer Patients
Status: COMPLETED
Conditions: Rectal Adenocarcinoma
Interventions: DRUG: Bevacizumab|DRUG: Oxaliplatin|DRUG: 5-FU|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Placebo-controlled Trial With rFXIII Administered to Subjects With Mild to Moderate Active Ulcerative Colitis
Status: TERMINATED
Conditions: Inflammation|Ulcerative Colitis
Interventions: DRUG: catridecacog|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of BGB-A333 Alone and in Combination With Tislelizumab in Advanced Solid Tumors
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: DRUG: BGB-A333|DRUG: BGB-A317
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness and Safety of Intravesical Gemcitabine Instillation to Prevent Intravesical Recurrence
Status: UNKNOWN
Conditions: Urothelial Carcinoma
Interventions: DRUG: Intravesical 2000mg/52.6ml gemcitabine instillation|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Efficacy of Intranasal Kinetic Oscillation Stimulation in the Preventive Treatment of Chronic Migraine
Status: COMPLETED
Conditions: Chronic Migraine
Interventions: DEVICE: Chordate System S211 in treatment mode|DEVICE: Chordate System S211 in placebo mode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity of One Dose of Inactivated Trivalent Flu Vaccine Administered to Non-elderly Adult and Elderly Subjects
Status: COMPLETED
Conditions: Seasonal Influenza
Interventions: BIOLOGICAL: Trivalent subunit inactivated flu vaccine, Formulation 2010-2011
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Study to Test the Effectiveness of Combining Conventional and Complementary Medicine to Treat Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: BEHAVIORAL: Integrative care for low back pain|BEHAVIORAL: Conventional treatment for low back pain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Algorithm Guided Treatment Strategies for Bipolar Depression
Status: UNKNOWN
Conditions: Bipolar Disorder
Interventions: DRUG: Lithium|DRUG: Quetiapine|DRUG: Shuganjieyu capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Silver Diamine Fluoride (SDF) in Arresting Cavitated Caries Lesions
Status: COMPLETED
Conditions: Cavities of Teeth
Interventions: DRUG: Silver Diamine Fluoride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Family Empowerment Program on Coping, Problem Solving in Parents, and Quality of Life in Children With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: BEHAVIORAL: family empowerment program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized Study Assess the Safety and Efficacy of Tacrolimus vs Prograf® in Renal Transplantation Treatment
Status: WITHDRAWN
Conditions: Renal Transplant
Interventions: DRUG: Tacrolimus from EMS|DRUG: Prograf
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Nivolumab and Hydroxychloroquine or Nivolumab/Ipilimumab and Hydroxychloroquine in Advanced Melanoma
Status: RECRUITING
Conditions: Melanoma
Interventions: DRUG: Nivolumab|DRUG: Hydroxychloroquine|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fixed-dose Versus Concentration-controlled Mycophenolate Mofetil for the Treatment of Active Lupus Nephritis
Status: TERMINATED
Conditions: Lupus Nephritis
Interventions: DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Microplasmin Intravitreal Injection for Non-surgical Treatment of Focal Vitreomacular Adhesion. The MIVI-TRUST (TG-MV-006) Trial.
Status: COMPLETED
Conditions: Vitreomacular Adhesion
Interventions: DRUG: 125 µg Ocriplasmin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of BI 2536 BS in Patients With Advanced Solid Tumours With Repeated Administration in Patients With Clinical Benefit
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: BI 2536
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of IL-21/Ipilimumab Combination in the Treatment of Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: BMS-982470 (recombinant interleukin-21)|BIOLOGICAL: BMS-982470 (recombinant interleukin-21)|BIOLOGICAL: BMS-982470 (recombinant interleukin-21)|BIOLOGICAL: BMS-982470 (recombinant interleukin-21)|BIOLOGICAL: Ipilimumab|BIOLOGICAL: Ipilimumab|BIOLOGICAL: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaginal Progesterone Versus Cervical Cerclage for Pregnant Women With Short Cervix and History of PTL and/or MTM
Status: RECRUITING
Conditions: Premature Labour
Interventions: DRUG: Progesterone|PROCEDURE: Cervical cerclage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Normothermic Ex Vivo Lung Perfusion (EVLP) For An Improved Assessment of Donor Lungs For Transplantation
Status: COMPLETED
Conditions: Lung Transplantation
Interventions: DRUG: Ex vivo lung perfusion with Steen Solution™
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Dental Maturation and Mandibular Bone Morphology in Childhood Rheumatic Diseases
Status: COMPLETED
Conditions: Childhood Rheumatic Diseases
Interventions: RADIATION: Panoramic rad.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Esophageal Protection Study: A Multicenter Study
Status: RECRUITING
Conditions: AF - Atrial Fibrillation|Complication|Atrio-Esophageal Fistula
Interventions: DEVICE: ensoETM. Esophageal cooling during AF ablation|DEVICE: Esophageal temperature monitoring probe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Assessing the Safety, Tolerability, and Pharmacokinetics of SEP-363856 in Male and Female Subjects With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: SEP-363856|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Yoga on Ambulatory Blood Pressure in Patients With Pre- and Stage I Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: OTHER: Yogic practice|OTHER: Conventional Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Humira in Rheumatoid Arthritis - Do Bone Erosions Heal?
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Arthritis|Joint Diseases
Interventions: DRUG: Adalimumab (Humira)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving BP Control in Diverse Populations Using BP MAP
Status: UNKNOWN
Conditions: Hypertension
Interventions: OTHER: Self-Guided M.A.P. BP Improvement Program|OTHER: Full Support M.A.P. BP Improvement Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Imaging, Cognitive Enhancement and Early Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: BEHAVIORAL: Cognitive Enhancement Therapy|BEHAVIORAL: Enriched Supportive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effect of Low-dose Prednisone Combined With MMF and FK506 in Focal Segmental Glomerulosclerosis
Status: UNKNOWN
Conditions: Focal Segmental Glomerulosclerosis
Interventions: DRUG: prednisone, FK506, MMF|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Multidisciplinary Review of Drug Prescriptions on Patient Safety in a Residence for Dependent Elderly
Status: COMPLETED
Conditions: Geriatrics|Residence for Dependent Elderly|Health Services for the Aged
Interventions: OTHER: Before-after study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy in Treating Young Patients With Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: cyclophosphamide|DRUG: dacarbazine|DRUG: prednisolone|DRUG: prednisone|DRUG: procarbazine hydrochloride|DRUG: vincristine sulfate|RADIATION: fludeoxyglucose F 18|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Effectiveness of SAMSCA® (Tolvaptan) in Children and Adolescents With Euvolemic or Hypervolemic Hyponatremia
Status: TERMINATED
Conditions: Hyponatremia
Interventions: DRUG: Tolvaptan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transnasal Endoscopy in Obese Patients Are Candidates for Bariatric Surgery
Status: UNKNOWN
Conditions: Obesity|Bariatric Surgery Candidate
Interventions: PROCEDURE: transnasal endoscopy|DRUG: Local Anesthetics,Topical
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Use of tDCS Applied to the Orbitofrontal Cortex to Improve Risky Decision-making in a Clinical Population
Status: RECRUITING
Conditions: Mood Disorders|Depression|Suicide
Interventions: DEVICE: Active transcranial direct current stimulation (tDCS)|DEVICE: Sham transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety of Repeated Doses of GSK189075 and WELLBUTRIN SR in Healthy Male Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: GSK189075|DRUG: Bupropion|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Functional Status of Jejunoplasty and Coloplasty and Its Impact on Quality of Life (CEREC)
Status: RECRUITING
Conditions: Quality of Life|Dysphagia
Interventions: OTHER: EORTC QLQ-C30|OTHER: EORTC QLQ-OG25|OTHER: GIQLI|OTHER: SWAL QoL|PROCEDURE: Videofluoroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SCALE-UP Utah II: Community-Academic Partnership to Address COVID-19 Conversational Agent Study
Status: COMPLETED
Conditions: COVID-19
Interventions: BEHAVIORAL: Text-Messaging (TM)|BEHAVIORAL: Conversational Agent (CA)|BEHAVIORAL: Patient Navigation (PN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: GODART Pilot and Feasibility
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Weekly Automated Health Coaching|BEHAVIORAL: Weekly Human Health Coaching|BEHAVIORAL: Adapted Reward Level|BEHAVIORAL: Fixed Gamified Reward Level
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Wavefront Analysis and Contrast Sensitivity After Cataract Surgery With Akreos Advanced Optics Intraocular Lens Implantation
Status: COMPLETED
Conditions: Lens Implantation, Intraocular
Interventions: PROCEDURE: implantation of intraocular lens (IOL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cosmetic Outcome of Electrocautery, Scalpel and PEAK PlasmaBlade for Surgical Breast Incisions
Status: NOT_YET_RECRUITING
Conditions: Wound Complication|Surgical Wound Infection|Post-operative Pain|Postoperative Complications|Scar
Interventions: DEVICE: Scalpel and standard electrocautery or PEAK PlasmaBlade|DEVICE: PEAK PlasmaBlade|DEVICE: Standard Electrocautery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surfactant Application During Spontaneous Breathing With Continuous Positive Airway Pressure (CPAP) in Premature Infants < 27 Weeks
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Newborn
Interventions: DRUG: Curosurf|DRUG: Curosurf
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid
Status: RECRUITING
Conditions: Preclinical Alzheimer's Disease|Early Preclinical Alzheimer's Disease
Interventions: DRUG: Lecanemab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: This Study in Healthy Men Tests How Different Doses of BI 1358894 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Tests How BI 1358894 Affects the Way the Body Breaks Down Midazolam
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1358894|DRUG: Placebo|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metformin for Reduction of Paclitaxel-Related Neuropathy in Patients With Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Metformin|OTHER: Placebo|BEHAVIORAL: Questionnaires|OTHER: Sensory and Fine-Motor Tests
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Oral Vancomycin Prophylaxis for Prevention of Recurrent Clostridium Difficile Infection
Status: COMPLETED
Conditions: Recurrent Clostridium Difficile Infection|Clostridium Difficile Infection|CDI|C.Difficile Diarrhea|C. Diff Colitis|C.Difficile Colitis
Interventions: DRUG: Vancomycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Early Feasibility Study of the Percutaneous Osseointegrated Prosthesis (POP)
Status: UNKNOWN
Conditions: Traumatic Amputee
Interventions: DEVICE: Percutaneous Osseintegrated Prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis.
Status: COMPLETED
Conditions: Sepsis, Severe|Septic Shock
Interventions: DRUG: Ascorbic Acid|DRUG: Thiamine|DRUG: Hydrocortisone|DRUG: Sodium Chloride 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Riboflavin on Faecalibacterium Prausnitzii and the Gut Microbiota
Status: COMPLETED
Conditions: Gut Microbiota
Interventions: DIETARY_SUPPLEMENT: Riboflavin Dose 1|DIETARY_SUPPLEMENT: Riboflavin Dose 2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vancomycin Prophylaxis in Recurrent Clostridium Difficile Infection
Status: UNKNOWN
Conditions: Clostridium Difficile Infection
Interventions: DRUG: Vancomycin|DIETARY_SUPPLEMENT: fruit juice/placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT)
Status: ACTIVE_NOT_RECRUITING
Conditions: Medulloblastoma, Childhood|Atypical Teratoid/Rhabdoid Tumor of CNS|Embryonal Tumor With Multilayered Rosettes|Pineoblastoma|Embryonal Tumor of CNS
Interventions: BIOLOGICAL: Multi-tumor antigen specific cytotoxic T lymphocytes (TSA-T) directed against proteogenomically determined personalized tumor-specific antigens (TSA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Thoracic Paravertebral Analgesia for Video-assisted Thoracoscopic Surgery
Status: TERMINATED
Conditions: Postoperative Pain
Interventions: DRUG: Continuous infusion of bupivacaine|DRUG: Single dose of bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Whole Foods Supplementation on Cognition
Status: COMPLETED
Conditions: Sub-optimal Cognitive Function|Sub-optimal Immune Function
Interventions: DIETARY_SUPPLEMENT: Ginkgo Synergy® and Choline|DIETARY_SUPPLEMENT: OPC Synergy® and Catalyn|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prasugrel Or Ticagrelor De-escalation in NSTE-ACS
Status: NOT_YET_RECRUITING
Conditions: Non ST Segment Elevation Acute Coronary Syndrome|Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)|Unstable Angina
Interventions: DRUG: De-escalation to ticagrelor 60 mg at day 30|DRUG: De-escalation to prasugrel 5 mg at day 30|DRUG: Switch to ticagrelor 60 mg at day 45|DRUG: Switch to prasugrel 5 mg at day 45
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Bone Strength Measured by DensiProbe on Bone Related Fixation Failure
Status: TERMINATED
Conditions: Femoral Fractures|Hip Fractures|Osteoporosis|Bone Density
Interventions: DEVICE: DensiProbe Hip
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Investigating Predictive Factors of Diabetes Occurence After Duodenalpancreatectomy
Status: RECRUITING
Conditions: GLUCOSE METABOLISM|DIABETES|PANCREATIC ISLETS|Exocrine Pancreatic Dysfunction|Exocrine Pancreas Conditions|Exocrine Pancreatic Insufficiency|Endocrine Pancreas Disorder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Efficacy and Safety of NIS793 in Combination With Standard of Care (SOC) Chemotherapy in First-line Metastatic Pancreatic Ductal Adenocarcinoma (mPDAC) - daNIS-2
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: NIS793|DRUG: Nab-paclitaxel|DRUG: Gemcitabine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Injectable Platelet Rich Fibrin With Collagen Matrix in Treatment of Multiple Gingival Recession.
Status: UNKNOWN
Conditions: Gingival Diseases|Traumatic Injury
Interventions: PROCEDURE: CAF+CM|PROCEDURE: I-PRF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Strength Physical Exercise Program in Colorectal Cancer Patients Undergoing Chemotherapy Treatment
Status: NOT_YET_RECRUITING
Conditions: Oncology|Chemotherapy-induced Peripheral Neuropathy
Interventions: OTHER: Exercise|OTHER: Physical activity recommendations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MYPP-trial: Myo-inositol Supplementation to Prevent Pregnancy Complications in Women With Polycystic Ovary Syndrome.
Status: UNKNOWN
Conditions: Gestational Diabetes Mellitus|Preeclampsia|Preterm Birth|Polycystic Ovary Syndrome
Interventions: DIETARY_SUPPLEMENT: Myo-inositol and routinely recommended folic acid|DIETARY_SUPPLEMENT: Routinely recommended folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: 30-Minutes of Listening to Relaxing Music on Attendees of a Workshop Session at a Local Conference
Status: NOT_YET_RECRUITING
Conditions: Depression|Anxiety|Autonomic Dysregulation
Interventions: BEHAVIORAL: Listening to Relaxing Music
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fiber Longer Term Study on Energy Intake
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: LM pectin (10%)|DIETARY_SUPPLEMENT: gelatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of SM934 Compared to Placebo in Adult Subjects With Active Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: SM934|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Poly-ICLC (Hiltonol®) Vaccine In Malignant Pleural Mesothelioma
Status: RECRUITING
Conditions: Malignant Pleural Mesothelioma
Interventions: BIOLOGICAL: Safety|BIOLOGICAL: Expansion Cohort
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AD 32 With or Without BCG After Surgery in Treating Patients With Newly Diagnosed or Recurrent Superficial Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: BIOLOGICAL: BCG vaccine|DRUG: valrubicin|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Haloperidol, Quetiapine and Placebo in the Pharmacological Treatment of Delirium
Status: COMPLETED
Conditions: Delirium
Interventions: DRUG: Quetiapine|DRUG: Haloperidol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NADIM II: Neo-Adjuvant Immunotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention
Status: COMPLETED
Conditions: Pregnancy Complications|Preeclampsia
Interventions: DRUG: Folic Acid 4 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Negative Pressure Wound Therapy for Surgical Site Infection Prevention in Common Femoral Artery Exposure
Status: WITHDRAWN
Conditions: Surgical Site Infection|Groin Infections
Interventions: DEVICE: Negative Pressure Pressure Wound Therapy|PROCEDURE: Standard Wound Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Lixisenatide Versus Insulin Glulisine on Top of Insulin Glargine With or Without Metformin in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Lixisenatide (AVE0010)|DRUG: Insulin glulisine QD|DRUG: Insulin glulisine TID|DRUG: Insulin Glargine (Mandatory background drug)|DRUG: Metformin (Background drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Episodic Future Thinking and Compassion
Status: COMPLETED
Conditions: Compliant Behavior|Self-Control|Impulsive Behavior
Interventions: BEHAVIORAL: Episodic Future Thinking|BEHAVIORAL: Compassion Training|BEHAVIORAL: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Glucose Response in Persons With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Oral nutrition supplement - control|OTHER: Oral nutrition supplement - test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Early Prosthetic Fitting in Patients With Below-knee Amputation
Status: ACTIVE_NOT_RECRUITING
Conditions: Amputation Stump
Interventions: BEHAVIORAL: Early Rehab Group|OTHER: Delayed Rehab Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Nivolumab in Combination With Ipilimumab (Part 1); Nivolumab Plus Ipilimumab in Combination With Chemotherapy (Part 2) as First Line Therapy in Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small-Cell Lung Cancer
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: Ipilimumab|DRUG: Platinum Doublet Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Ranibizumab in Subjects With Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Choroidal Neovascularization|Age-related Macular Degeneration
Interventions: DRUG: rhuFab V2 (ranibizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of the Ultrasonic Propulsion of Kidney Stones
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Stones|Nephrolithiasis|Urolithiasis
Interventions: DEVICE: Propulse 1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of SGLT-2 Inhibition on Myocardial Fibrosis and Inflammation as Assessed by Cardiac MRI in Patients With DM2
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Myocardial Fibrosis|Myocardial Inflammation
Interventions: DRUG: dapagliflozin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Efficacy and Tolerability of MK0533 in Patients With Type 2 Diabetes (0533-005)
Status: TERMINATED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: MK0533|DRUG: Comparator: Placebo (unspecified)|DRUG: Comparator: pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Bevacizumab and Triamcinolone in Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: PROCEDURE: Intravitreal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The KIN-FAST Trial (KIN001 For Accelerated Symptoms Termination) in Non Hospitalized Patients Infected With SARS-CoV-2
Status: SUSPENDED
Conditions: COVID-19
Interventions: DRUG: KIN001|DRUG: KIN001-Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Pharmacokinetics and Safety of TNX-102 SL Tablets and Cyclobenzaprine Oral Tablet in Healthy Adults
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DRUG: SL TNX-102 at 2.4 mg|DRUG: SL TNX-102 at 4.8 mg|DRUG: SL TNX-102-A at 2.4 mg|DRUG: Cyclobenzaprine tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adalimumab Administered in Korean Rheumatoid Arthritis Subjects Treated With Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: adalimumab|DRUG: methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Analysis of Prognostic Factors for Functional Outcomes in Patients With Acute Subdural Hematoma
Status: RECRUITING
Conditions: Acute Subdural Hematoma|Acquired Brain Injury
Interventions: PROCEDURE: Decompressive craniectomy with evacuation of subdural hematoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The DISTAL-2 Study: Docetaxel Alone or in Combination in Second-line Treatment of Advanced Non Small-Cell Lung Cancer
Status: TERMINATED
Conditions: Advanced Non-Small Cell Lung Cancer
Interventions: DRUG: docetaxel|DRUG: vinorelbine|DRUG: gemcitabine|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: THE EFFECT OF HAND AND FOOT MASSAGE ON FATIGUE IN HEMODIALYSIS PATIENTS
Status: COMPLETED
Conditions: Hemodialysis Patients
Interventions: OTHER: hand massage|OTHER: foot massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Longitudinal At Home Smell Testing to Detect Infection by SARS-CoV-2
Status: RECRUITING
Conditions: Anosmia|Asymptomatic COVID-19|COVID-19 Respiratory Infection|Influenza|Healthy
Interventions: DEVICE: AROMHA Longitudinal Smell Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Healthy Term Infants Fed Milk-Based Infant Formula
Status: COMPLETED
Conditions: Tolerance
Interventions: OTHER: Control Infant Formula|OTHER: Experimental Infant Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Lenalidomide and Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Recurrent B-Cell Prolymphocytic Leukemia|Recurrent Chronic Lymphocytic Leukemia|Recurrent Small Lymphocytic Lymphoma|Refractory B-Cell Prolymphocytic Leukemia|Refractory Chronic Lymphocytic Leukemia|Refractory Small Lymphocytic Lymphoma
Interventions: DRUG: Ibrutinib|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fludarabine and Busulfan Followed by Donor Peripheral Stem Cell Transplant and Antithymocyte Globulin, Tacrolimus, and Methotrexate in Treating Patients With Myeloid Cancer
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases
Interventions: BIOLOGICAL: anti-thymocyte globulin|DRUG: busulfan|DRUG: fludarabine phosphate|DRUG: methotrexate|DRUG: tacrolimus|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Lebrikizumab (LY3650150) in Participants 6 Months to <18 Years of Age With Moderate-to-Severe Atopic Dermatitis
Status: RECRUITING
Conditions: Atopic Dermatitis|Eczema
Interventions: DRUG: Lebrikizumab|DRUG: Placebo|DRUG: Topical corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Dental Floss Adherence and Gingival Health With SMS and an Innovative Floss Holder
Status: COMPLETED
Conditions: Behavior|Gingivitis
Interventions: DEVICE: New Floss Holder - Gum Chucks|DEVICE: New Floss Holder - Gum Chucks/SMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION