pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study in Beta-thalassaemia or Myelodysplastic Syndrome Patients to Investigate the Safety and Tolerability of SLN124
Status: WITHDRAWN
Conditions: Non-transfusion-dependent Thalassemia|Low Risk Myelodysplastic Syndrome
Interventions: DRUG: SLN124 is a GalNAc conjugated double stranded fully modified siRNA. Sodium chloride 0.9% w/v is used as Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Working Memory Training in Older Adults With Mild Cognitive Impairment : Impacts on Cognition and Ecological Activities
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Alzheimer Disease
Interventions: BEHAVIORAL: Attention Process Training (APT-II)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Low and Inter-mediate Grade Chondrosarcoma of the Skull Base
Status: UNKNOWN
Conditions: Chondrosarcoma
Interventions: RADIATION: carbon ion therapy|RADIATION: proton therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Dupilumab in Adult Patients With Bullous Pemphigoid
Status: ACTIVE_NOT_RECRUITING
Conditions: Bullous Pemphigoid
Interventions: DRUG: dupilumab|DRUG: Matching Placebo|DRUG: Oral corticosteroids (OCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Efficacy and Safety of LIV-GAMMA SN Inj. in ABO-Incompatible Liver Transplantation
Status: TERMINATED
Conditions: Liver Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Co-administration of Sitagliptin and Atorvastatin in Inadequately Controlled Type 2 Diabetes Mellitus (MK-0431E-211)
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin|DRUG: Atorvastatin|OTHER: Placebo to sitagliptin|OTHER: Placebo to atorvastatin|DRUG: Metformin (open-label)|DRUG: Glimepiride (open-label)|DRUG: Glimepiride (double-blind)|DRUG: Placebo to glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Regulatory Role of miRNA 27 Follistatin Like Protein-1 Gene in Multiple Scelerosis
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis
Interventions: DIAGNOSTIC_TEST: micro RNA 27- FLP1 gene expression|DIAGNOSTIC_TEST: The Expanded Disability Status Scale (EDSS)|DIAGNOSTIC_TEST: Electrophysiological assessment:|DIAGNOSTIC_TEST: MRI examination MRI brain:
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pyrotinib, Dalpiciclib(SHR6390) and Endocrine Therapy in Subjects With Dual-receptor Positive(ER+/HER2+) Advanced Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Dalpiciclib|DRUG: Pyrotinib|DRUG: Letrozole|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Cerebral Blood Flow Regulation
Status: RECRUITING
Conditions: Cerebral Arterial Diseases
Interventions: DRUG: Indomethacin 25 MG/50 MG|DRUG: Placebo - Lactose|DRUG: Ganirelix Acetate|DRUG: Testosterone Transdermal Product|DRUG: Estradiol Topical|DRUG: Antacid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of the Efficacy of Thoracolumbar Interfascial Plane Block and Erector Spina Plane Block in Lumbar Discectomy
Status: COMPLETED
Conditions: Lumbar Disc Herniation
Interventions: PROCEDURE: Modified thoracolumbar plane block (mTLIP)|PROCEDURE: Erector spinae plane block (ESP)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot Study of a Low Glycemic Load Diet in Adults With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis|Cystic Fibrosis-related Diabetes|Cystic Fibrosis With Intestinal Manifestations
Interventions: BEHAVIORAL: Low Glycemic Load Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketogenic Or LOGI Diet In a Breast Cancer Rehabilitation Intervention (KOLIBRI)
Status: COMPLETED
Conditions: Quality of Life
Interventions: OTHER: Standard diet (SD)|OTHER: Experimental 1: Ketogenic diet (KD).|OTHER: Experimental 2: "Low glycämic and insulinemic" diet (LOGI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A Phase III Study of BMS-512148 (Dapagliflozin) in Asian Patients With Type 2 Diabetes Who Are Not Well Controlled With Diet and Exercise
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Dapagliflozin|DRUG: Dapagliflozin|DRUG: Metformin|DRUG: Dapagliflozin Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Treatment Trial in Adult Subjects With Migraines
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Zavegepant|DRUG: Zavegepant matching placebo|DEVICE: Intranasal Aptar Pharma Unit Dose System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of Eggshell Powder in Primary Teeth Pulpotomy
Status: RECRUITING
Conditions: Pulpitis Reversible|Pulp Exposure, Dental
Interventions: PROCEDURE: pulpotomy|RADIATION: cone beam computed tomography (CBCT) assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Equivalence of Resorption of Empagliflozin/Metformin Administered as Combination Tablet Compared With Empagliflozin/Metformin as Single Tablets Administered Together
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Empagliflozin|DRUG: Metformin|DRUG: Empagliflozin|DRUG: Empagliflozin/Metformin|DRUG: Metformin|DRUG: Empagliflozin/Metformin|DRUG: Empagliflozin|DRUG: Metformin|DRUG: Empagliflozin/Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Cesarean Section Intravenous Acetaminophen and Postoperative Pain Control
Status: UNKNOWN
Conditions: Complications; Cesarean Section
Interventions: DRUG: Placebo|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of ANX-042 in Human Cardiorenal Syndrome
Status: ENROLLING_BY_INVITATION
Conditions: Heart Failure|Cardiorenal Disease|Renal Disfunction
Interventions: DRUG: ANX-042|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Omiganan 1% Gel in Preventing Catheter Infections/Colonization in Patients With Central Venous Catheters
Status: COMPLETED
Conditions: Infection
Interventions: DRUG: Omiganan 1% gel|DRUG: Povidone-Iodine 10%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Endoscopic Full Thickness Plication (GERD-X) for the Treatment of PPI Dependent GERD:
Status: COMPLETED
Conditions: Gastro Esophageal Reflux Disease
Interventions: DEVICE: GERD-X
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Epidemiological Study on the Relationship Between Respiratory Health and Air Pollution From Industrial Sources
Status: COMPLETED
Conditions: Airway Obstruction|Hypertension|Diabetes Mellitus|Dyslipidemias|Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: heteroevaluation scale by a nurse or doctor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prostate Cancer IMAGing IN Early Detection (IMAGINED Trial)
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: OTHER: Restricted Spectrum Imaging-Magnetic Resonance Imaging (RSI-MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase 3 Randomised Controlled Trial to Evaluate Efficacy and Safety of Anaprazole in Patients With Duodenal Ulcers.
Status: UNKNOWN
Conditions: Duodenal Ulcer，DU
Interventions: DRUG: Anaprazole Sodium|DRUG: Rabeprazole|DRUG: Rabeprazole Placebo|DRUG: Anaprazole Sodium Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-therapeutic Validation of the Virtual Reality-based Exposure Scenario for CBT "ReVBED" for the Induction of Food Craving in Patients With Bulimia and Binge Eating Disorder (BED)
Status: COMPLETED
Conditions: Bulimia Nervosa|Binge-Eating Disorder
Interventions: BEHAVIORAL: experimentation of the virtual reality "RevBED"
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of Booster With AZD1222, mRNA-1273, or MVC-COV1901 Against COVID-19
Status: COMPLETED
Conditions: COVID-19 Vaccine
Interventions: BIOLOGICAL: Half dose of MVC-COV1901|BIOLOGICAL: Full dose of MVC-COV1901|BIOLOGICAL: AZD1222|BIOLOGICAL: Half dose of mRNA-1273
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: To Evaluate the Hormonal Response to Low Blood Sugar After a Single Oral Dose of AZD1656 Suspension
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Insulin|DRUG: AZD1656
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Microbiologic Outcomes of aPDT in the Non-surgical Treatment of Implant Inflammation
Status: COMPLETED
Conditions: DENT IMPLANTS|LASER
Interventions: PROCEDURE: Conventional mechanical therapy|DRUG: Saline|DRUG: Methylene Blue|DEVICE: Light emitting laser|DEVICE: Non-light emitting laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Therapy and Gut Microbiome in Crohn's Disease and Ulcerative Colitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn's Disease
Interventions: OTHER: Specific carbohydrate diet|OTHER: Elemental diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dasatinib, Cytarabine, and Idarubicin in Treating Patients With High-Risk Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Recurrent Adult Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: cytarabine|DRUG: idarubicin|DRUG: dasatinib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of the Safety and Efficacy of Clarithromycin Extended-Release Tablets Versus Amoxicillin-Clavulanate for the Treatment of Acute Bacterial Sinusitis
Status: COMPLETED
Conditions: Acute Bacterial Sinusitis (ABS)
Interventions: DRUG: Clarithromycin|DRUG: Amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The People Like Us Evaluation Study
Status: COMPLETED
Conditions: HIV/AIDS|Sexually Transmitted Infection|Homosexuality|Health Behavior|Stigma, Social|Health Care Seeking Behavior
Interventions: BEHAVIORAL: People Like Us Online Video Series Intervention|BEHAVIORAL: Sexual Health Pamphlet (Standard of Care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Multiple Fields Radiotherapy Versus Intravenous Rituximab in the Treatment of Indolent Cutaneous Lymphomas B-cell With Multiple or Recurrent Lesions
Status: UNKNOWN
Conditions: Indolent Cutaneous B Cell Lymphomas
Interventions: DRUG: rituximab|RADIATION: Multi-fields radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Physical Activity and Break in Office Workers
Status: UNKNOWN
Conditions: Physical Activity|Sedentary Lifestyle
Interventions: BEHAVIORAL: TPAG with long break|BEHAVIORAL: TPAG with short break|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Oral Piroxicam Versus Buccal Fentanyl in Breakthrough Pain
Status: COMPLETED
Conditions: Neoplasm Metastases
Interventions: DRUG: oral perixicam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Revascularization of Failed Endodontically Treated Mature Permanent Teeth
Status: UNKNOWN
Conditions: Revascularization
Interventions: OTHER: Revascualrization|OTHER: Conventional endodontic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Penumbra Liberty Trial: Safety and Effectiveness in the Treatment of Wide-Neck Intracranial Aneurysms
Status: COMPLETED
Conditions: Wide-neck, Saccular Intracranial Aneurysms
Interventions: DEVICE: Stent assisted coiling with the Liberty Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early and Accurate Detection of Prostate Cancer in General Practice
Status: UNKNOWN
Conditions: Prostate Cancer|Prostate Neoplasm|Prostate Adenocarcinoma
Interventions: DIAGNOSTIC_TEST: PSA, STHLM3 and mpMRI for PC detection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: COG-PSYCHO : Social Cognition and Psychotic Characteristics: Genetic and Phenomic Approach
Status: RECRUITING
Conditions: Social Cognition of Schizophrenia, Bipolas or Depressed Patients
Interventions: GENETIC: ocytocine dosage and genetic analyse
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Escalating Doses of PM01183 in Combination With Gemcitabine in Patients With Specific Unresectable Solid Tumors
Status: COMPLETED
Conditions: Specific Advanced Solid Tumors
Interventions: DRUG: lurbinectedin (PM01183)|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluid Balance During Exercise in the Heat With Water, Flavored Placebo, or a Carbohydrate-electrolyte Beverage Intake (The APEX Study)
Status: COMPLETED
Conditions: Dehydration
Interventions: OTHER: Exercise Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: REVEAL: Randomized EValuation of the Effects of Anacetrapib Through Lipid-modification
Status: ACTIVE_NOT_RECRUITING
Conditions: Atherosclerotic Cardiovascular Disease
Interventions: DRUG: Anacetrapib|DRUG: Placebo anacetrapib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Plasma Biomarker in Predicting Response and Toxicity in HCC Patients Treated With Checkpoint Inhibitors With or Without SBRT
Status: COMPLETED
Conditions: Hepatocellular Carcinoma Non-resectable|Stereotactic Body Radiotherapy
Interventions: PROCEDURE: sterotatic body radiotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of GFH925 in Combination With Cetuximab in Previously Untreated Advanced NSCLC Harboring KRAS G12C Mutation
Status: RECRUITING
Conditions: Advance Non-small Cell Lung Cancer
Interventions: DRUG: GFH925|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Technical Failure During Colorectal Endoscopic Full Thickness Resection (EFTR): The "Through Thick and Thin" Study
Status: COMPLETED
Conditions: Endoscopic Full Thickness Resection (EFTR)|Residual /Recurrent Colorectal Lesion|Full-thickness Resection Device (FTRD)|Colorectal Adenoma|Non-lifting Colorectal Lesions|Intraprocedural Complication
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vaginal Cleansing Before Cesarean Delivery to Reduce Infection
Status: COMPLETED
Conditions: Complications; Cesarean Section
Interventions: PROCEDURE: Vaginal Cleansing|PROCEDURE: Abdominal Cleansing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Determine the Efficacy of ZPL-3893787 in Subjects With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: ZPL-3893787|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Resuscitation Markers in Trauma Patients
Status: COMPLETED
Conditions: Trauma|Hypovolemic Shock
Interventions: OTHER: Blood Lactate|OTHER: Blood Base Excess|OTHER: Blood B-type Natriuretic Peptide|OTHER: Blood Thromboelastometry (ROTEM)|OTHER: Near-infrared spectroscopy|OTHER: Sublingual videomicroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Modernizing Perinatal Syphilis Testing
Status: RECRUITING
Conditions: Syphilis
Interventions: DIAGNOSTIC_TEST: Quantitative polymerase chain reaction (qPCR) assay for detection of Treponema pallidum|DIAGNOSTIC_TEST: Aptima Treponema pallidum transcription-mediated amplification (TMA) assay for detection of Treponema pallidum|OTHER: Center for Disease Control (CDC) Sexually Transmitted Infections (STI) 2021 Treatment Guidelines for diagnosis of syphilis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Singapore Healthy Alternative Protein Evaluation Study
Status: UNKNOWN
Conditions: Diabetes Mellitus|Cardiovascular Diseases|Protein Metabolism Disorder
Interventions: DIETARY_SUPPLEMENT: Animal-based meats|DIETARY_SUPPLEMENT: Plant-based meat alternatives
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Respimat® Combivent Trial in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Atrovent Respimat (20 mcg)|DRUG: COMBIVENT MDI (36/206 mcg)|DRUG: Combivent Respimat (20 mcg/100 mcg)|DRUG: Placebo via corresponding inhaler for blinding purposes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: [18F]APN-1607 PET in Subjects With AD Compared to HC
Status: UNKNOWN
Conditions: Alzheimer's Disease|Mild Cognitive Impairment Due to Alzheimer's Disease|Healthy Volunteers
Interventions: DRUG: [18F]APN-1607
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Durvalumab and Tremelimumab in Combination With Chemotherapy in Virus-infected Patients With Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Carcinoma, Non-Small Cell Lung
Interventions: DRUG: Durvalumab|DRUG: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin for Treatment Antipsychotic Induced Amenorrhea in Female Schizophrenic Patients
Status: COMPLETED
Conditions: Amenorrhea
Interventions: DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Evaluation of SARS-CoV-2 (COVID-19) Antibody-containing Plasma thErapy
Status: TERMINATED
Conditions: COVID|Infectious Disease
Interventions: BIOLOGICAL: High-Titer COVID-19 Convalescent Plasma (HT-CCP)|BIOLOGICAL: Standard Plasma (FFP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Optimization of Infliximab in Moderate to Severe Plaque Psoriasis (Study P05315)
Status: TERMINATED
Conditions: Psoriasis
Interventions: DRUG: Infliximab|DRUG: Infliximab and methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EUS GUIDED Transduodenal Biopsy Using the 19G Flex
Status: COMPLETED
Conditions: Abdominal Neoplasms
Interventions: DEVICE: Expect™19Flex needle (Boston Scientific Corp.,Natick,MA,USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vitamin D and Resistance Exercise Training; Effects on Musculoskeletal Health in Frail Older Men and Women
Status: COMPLETED
Conditions: Sarcopenia|Muscle Atrophy|Osteoporosis
Interventions: OTHER: RET|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Metabolic Effects of Switching Kaletra to Boosted Reyataz
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: atazanavir/ritonavir|DRUG: lopinavir/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Clinical Utility Study of SSEC Fentanyl 40 mcg for Acute Post-op Pain Management in Pediatric Participants
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Muscle Activity Evaluation of Maxillary Bilateral Bounded Partial Denture Fabricated By Bre-Flex Versus Peek
Status: UNKNOWN
Conditions: Maxillary Class III Modification I Edentulous Patients
Interventions: PROCEDURE: Bre-flex maxillary partial denture|PROCEDURE: PEEK maxillary partial denture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Reducing Childhood Hearing Loss in an Alaska Native Population Through a New School Screening and Referral Process That Utilizes Mobile Health and Telemedicine
Status: COMPLETED
Conditions: Hearing Loss
Interventions: OTHER: Current Primary Care Referral Process|OTHER: Telemedicine Referral Process
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Long-Term Follow-up Safety After DDS Implantation With/Without CDNF Infusions
Status: UNKNOWN
Conditions: Parkinson Disease|Movement Disorders|Neuro-Degenerative Disease|Nervous System Diseases|Brain Diseases
Interventions: DEVICE: Renishaw Drug Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endermologie Versus Negative Pressure Therapy on Postmastectomy Lymphedema
Status: COMPLETED
Conditions: Mastectomy; Lymphedema
Interventions: DEVICE: Endermologie|DEVICE: Negative pressure therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Teen Driving Translation Study (NIH)
Status: RECRUITING
Conditions: Drive|Recidivism|Communication|Feedback, Psychological
Interventions: COMBINATION_PRODUCT: In-vehicle Device|BEHAVIORAL: Expert-Delivered Parent Communication Training|BEHAVIORAL: Peer-Delivered Parent Communication Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination of ETV, TQ-A3334 and TQ-B2450 for CHB (Neptune Study)
Status: UNKNOWN
Conditions: Chronic Hepatitis b
Interventions: DRUG: ETV|DRUG: TQ-A3334|DRUG: TQ-B2450
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Therapeutic Equivalence of Mometasone Furoate Nasal Spray, 50 mcg With Nasonex Nasal Spray in the Relief of the Signs and Symptoms of Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Mometasone Furoate Nasal Spray, 50 mcg|DRUG: Nasonex Nasal Spray, 50 mcg|DRUG: Placebo Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Safety and Performance of a New 2-piece Ostomy Product Compared With SenSura Click 2-piece
Status: COMPLETED
Conditions: Ileostomy - Stoma
Interventions: DEVICE: Coloplast test product|DEVICE: SenSura
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of β-alanine Supplementation on Muscle Carnosine
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: placebo|DIETARY_SUPPLEMENT: beta-alanine|DIETARY_SUPPLEMENT: beta-alanine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Phase II/III of Recombinant Human Serum Albumin
Status: COMPLETED
Conditions: Hepatic Ascites
Interventions: DRUG: Recombinant Human Serum Albumin|DRUG: Recombinant Human Serum Albumin|DRUG: Human serum albumin|DRUG: Human serum albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Resistance Training on Muscle Strength and Nutritional Status in Patients With Liver Cirrhosis
Status: UNKNOWN
Conditions: Liver Cirrhosis
Interventions: BEHAVIORAL: Nutrition and strength training|BEHAVIORAL: Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Acetylsalicylic Acid Reduce the Mortality of Patients Admitted to an Intensive Care Unit
Status: TERMINATED
Conditions: Critical Illness
Interventions: DRUG: Acetylsalicylic acid lysinate|DRUG: 0.9% sodium-chloride solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Vagal Nerve Stimulation as Novel Treatment to Improve Functional Outcomes in Veterans With Alcohol Use Disorder
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder
Interventions: DEVICE: Cervical transcutaneous vagus nerve stimulation (active comparator)|DEVICE: Cervical transcutaneous vagus nerve stimulation (sham comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Memory Training in Patients With Amnestic Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Memory Training|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Trial About Safety and Efficacy of Combined Treatment With Cerebrolysin in Acute Ischemic Hemispheric Stroke Patients Undergoing EndoVascular Treatment (EVT)
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Cerebrolysin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of SOW Mouthwash on the Level of IL_1β in GCF and Some Clinical Periodontal Parameters for Patients With Gingivitis
Status: UNKNOWN
Conditions: Generalized Gingivitis
Interventions: DRUG: Super Oxide water|DRUG: Chlorhexidine mouthwash|OTHER: Distilled water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Xbox Kinect Virtual Reality and Motor Imagery on Lower Limb Function in Chronic Stroke Patients
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Virtual reality training with motor imagery|OTHER: Conventional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Shuxuening Injection for the Prevention of CVS in Patients With aSAH(SXN-CVS)
Status: RECRUITING
Conditions: Subarachnoid Hemorrhage, Aneurysmal
Interventions: DRUG: Shuxuening injection or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Cassia Fistula Plus Senna Alexandrina Miller (Sugar Free) in the Chronic Functional Constipation (CFC).
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: SENNA+CASSIA(Naturetti)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Intracranially Implanted Carmustine to Treat Recurrent Malignant Glioma
Status: UNKNOWN
Conditions: Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|Anaplastic Oligoastrocytoma|Glioblastoma
Interventions: DRUG: Carmustine(BCNU)|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Auto Adjusting Dynamic AFO
Status: RECRUITING
Conditions: Lower Limb; Fusion, Congenital|Lower Limb Fracture|Ankle Foot Injury
Interventions: DEVICE: Variable Stiffness AFO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability and Pharmacokinetics Study of EGT0001474 in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: EGT0001474|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Atezolizumab (MPDL3280A) in Combination With Epacadostat (INCB024360) in Subjects With Previously Treated Stage IIIB or Stage IV Non-Small Cell Lung Cancer and Previously Treated Stage IV Urothelial Carcinoma (ECHO-110)
Status: TERMINATED
Conditions: NSCLC (Non-small Cell Lung Carcinoma)|UC (Urothelial Cancer)
Interventions: DRUG: atezolizumab|DRUG: epacadostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia
Status: COMPLETED
Conditions: Choriocarcinoma|FIGO Stage I Gestational Trophoblastic Tumor|FIGO Stage II Gestational Trophoblastic Tumor|FIGO Stage III Gestational Trophoblastic Tumor|Hydatidiform Mole
Interventions: BIOLOGICAL: Dactinomycin|DRUG: Leucovorin Calcium|DRUG: Methotrexate|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Open Label Study of Dabigatran Etexilate in Elective Percutaneous Coronary Intervention
Status: COMPLETED
Conditions: Heart Catheterization
Interventions: DRUG: dabigatran 110 mg|DRUG: dabigatran 150 mg|DRUG: unfractionated heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analysis of Bone Quality in Adult Patients With Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|Osteoporosis
Interventions: OTHER: Densitometry with Trabecular Bone Score|OTHER: Quantitative Ultrasound of Calcaneus|OTHER: Laboratory test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment Trial of Subclinical Hypothyroidism in Down Syndrome
Status: COMPLETED
Conditions: Down Syndrome|Subclinical Hypothyroidism
Interventions: DRUG: Levothyroxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Brain and Peripheral Electrical Stimulation in Chronic Low Back Pain: a Factorial Design
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: PROCEDURE: Transcranial direct current stimulation (tDCS)|PROCEDURE: Transcutaneous electrical nerve stimulation (TENS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Performance and Long-term Safety of FlowOx2.0™ in Patients With Multiple Sclerosis - Impact on Spasticity and Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis|Spasticity, Muscle|Pain, Chronic
Interventions: DEVICE: FlowOx 2.0|DEVICE: FlowOx2.0 (Sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Periodontitis and Cardiovascular Events or "PAVE"
Status: COMPLETED
Conditions: Cardiovascular Disease|Coronary Heart Disease|Myocardial Infarction|Cerebrovascular Accident
Interventions: PROCEDURE: Periodontal Treatment: SRP|PROCEDURE: Referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Integrated Imaging System For In Vivo Detection of Fluorescently Labeled Lesions
Status: ACTIVE_NOT_RECRUITING
Conditions: Invasive Breast Cancer
Interventions: DEVICE: Smart Goggle|OTHER: Cardio-Green|DEVICE: SPY Elite Imaging system|DEVICE: Quest near-infrared (NIR) Imaging system|DEVICE: PDE Imaging system|DEVICE: Gamma probe|OTHER: Blue Dyes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Multi-level Evaluation of Chemotherapy-induced Febrile Neutropenia Prophylaxis, Outcomes, and Determinants With Granulocyte-colony Stimulating Factor
Status: COMPLETED
Conditions: Febrile Neutropenia|Cancer|Breast Cancer|Ovarian Cancer|Lung Cancer|Prostate Cancer|Multiple Myeloma|Bladder Cancer|B-cell Lymphoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia
Status: RECRUITING
Conditions: Actinic Keratoses|Aging|Non-Melanoma Skin Cancer
Interventions: DEVICE: Fractionated Laser Resurfacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Accuracy of Bladder Scanners in Post-operative Voiding Trials
Status: WITHDRAWN
Conditions: Pelvic Floor Disorders
Interventions: DEVICE: Bladder scan post void residual|PROCEDURE: Straight catheter post void residual|PROCEDURE: Back fill voiding trial
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Investigate the Efficacy and Safety of GSK1070806 in Obese Subjects With T2DM
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: BIOLOGICAL: GSK1070806|OTHER: Placebo (saline)|BIOLOGICAL: GSK1070806
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tablet-guided Versus Freehand (Tab-Guide) Ventriculostomy : Study Protocol to the Test Accuracy of Ventriculostomy in a Randomized Controlled Trial
Status: UNKNOWN
Conditions: Hydrocephalus.
Interventions: DEVICE: Tablet-guided ventriculostomy|PROCEDURE: Freehand
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fasiglifam 25 mg BID vs 50 mg QD
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Fasiglifam|DRUG: Placebo to fasiglifam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Investigational Monoclonal Antibody, VYD2311, in Healthy Participants
Status: NOT_YET_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: VYD2311|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: MRI Based Study to Assess Brain-gut Axis in Obesity
Status: UNKNOWN
Conditions: Obesity
Interventions: OTHER: Nutritional Drink A|OTHER: Nutritional Drink B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prevention of Restenosis After Genous Stent Implantation Using a Paclitaxel Eluting Balloon in Coronary Arteries
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Genous stent implantation with paclitaxel-eluting balloon dilation|DEVICE: Genous stent implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Analysis of the Dentoskeletal Effects of the Expander With Differential Opening
Status: UNKNOWN
Conditions: Maxillary Constriction|Unilateral Posterior Crossbite|Bilateral Posterior Crossbite|Mandibular Dental Arch Constriction
Interventions: DEVICE: Differential rapid maxillary expansion|DEVICE: Conventional rapid maxillary expansion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Gabapentin Extended Release (G-ER) in the Treatment of Vasomotor (Hot Flashes/Hot Flushes) Symptoms in Postmenopausal Women
Status: COMPLETED
Conditions: Hot Flashes
Interventions: DRUG: Gabapentin Extended Release tablets|DRUG: Gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Lowering Low-density Lipoprotein Cholesterol Levels to New Targets on Cardiovascular Complications in Peritoneal Dialysis Patients
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: OTHER: LDL-cholesterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anticoagulation in Stent Intervention
Status: UNKNOWN
Conditions: Atrial Fibrillation|Stroke
Interventions: DRUG: Acetylsalicylic Acid + clopidogrel + acenocoumarol|DRUG: Acetylsalicylic Acid + clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Toward a Generalizable Closed-loop Neurofeedback-based BCI for Attention Training
Status: RECRUITING
Conditions: Neurofeedback
Interventions: BEHAVIORAL: sham neurofeedback|BEHAVIORAL: nonadaptive neurofeedback|BEHAVIORAL: adaptive neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Cemiplimab - TP Induction Chemotherapy in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck
Status: RECRUITING
Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Cemiplimab|DRUG: Cisplatin|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metadoxine as a Therapy for Severe Alcoholic Hepatitis
Status: COMPLETED
Conditions: Severe Alcoholic Hepatitis
Interventions: DRUG: Prednisone plus Metadoxine|DRUG: Pentoxifylline plus Metadoxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of 68Ga-ABY-025 PET for Non-invasive Quantification of HER2-expression in Advanced Breast Cancer
Status: RECRUITING
Conditions: HER2-positive Breast Cancer
Interventions: DIAGNOSTIC_TEST: ABY-PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase 2 Study of AT13387 (Onalespib) in ALK+ ALCL, MCL, and BCL-6+ DLBCL
Status: TERMINATED
Conditions: Recurrent Anaplastic Large Cell Lymphoma|Recurrent Diffuse Large B-Cell Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Transformed Non-Hodgkin Lymphoma|Refractory Anaplastic Large Cell Lymphoma|Refractory Diffuse Large B-Cell Lymphoma|Refractory Mantle Cell Lymphoma|Refractory Transformed Non-Hodgkin Lymphoma
Interventions: DRUG: Onalespib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact on Ovarian Reserve After Single-port, Two-port, or Four-port Access Laparoscopic Ovarian Cyst Enucleation
Status: UNKNOWN
Conditions: Ovarian Cyst
Interventions: PROCEDURE: Laparoscopic ovarian cyst enucleation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, and Efficacy of ASC41 Tablets in Adult Patients With NASH
Status: RECRUITING
Conditions: Non-alcoholic Fatty Liver Disease|Non-alcoholic Steatohepatitis
Interventions: DRUG: 2mg of ASC41|DRUG: 4mg of ASC41 (2 tablets of 2 mg ASC41)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Toripalimab (JS001) Combined With Neoadjuvant Chemotherapy in Patients With Resectable Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Resectable Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma
Interventions: COMBINATION_PRODUCT: Toripalimab combined with cisplatin and paclitaxel|COMBINATION_PRODUCT: Placebo combined with cisplatin and paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: POWERPLAY Phase 2: Development and Evaluation in Male-dominated Workplaces
Status: COMPLETED
Conditions: Men|Health Behavior|Mental Health Wellness 1|Health Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: POWERPLAY
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Therapeutic Efficacy of Anti-CD19 CAR-T Cells in Children With Refractory Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus|CAR-T Cell Therapy
Interventions: BIOLOGICAL: anti-CD19-CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel Polymeric Micelles for Injection Versus TPC on the Treatment of HER2-negative Metastatic Breast Cancer (MBC).
Status: RECRUITING
Conditions: Metastatic Breast Cancer (MBC)
Interventions: DRUG: Paclitaxel Polymeric Micelles for Injection|DRUG: Eribulin Mesilate injection|DRUG: Capecitabine Tablets|DRUG: Gemcitabine Hydrochloride for Injection|DRUG: Vinorelbine Tartrate Injection|DRUG: Paclitaxel (albumin-bound)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT