pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Early Nutritional Intervention During Concurrent Chemoradiotherapy for Local Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Local Advanced Non-small Cell Lung Cancer
Interventions: DIETARY_SUPPLEMENT: Early Nutrition Intervention from the start of CCRT|RADIATION: Thoracic radiotherapy|DRUG: Weekly DP chemotherapy concurrent with thoracic radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paper- vs Digital Application-based Exercises to Support Rehabilitation After Osteosynthesis of Distal Radius Fracture
Status: RECRUITING
Conditions: Distal Radius Fracture
Interventions: OTHER: Standard hand therapy + home digital application-based exercises|OTHER: standard hand therapy + home paper-based exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase II, Randomized, Placebo-controlled Trial in Patients With Charcot-marie-tooth Disease Type 1A
Status: COMPLETED
Conditions: Charcot-Marie-Tooth Disease|Hereditary Neuropathy With Liability to Pressure Palsies|Genetic Disorders
Interventions: DRUG: PXT3003 Low dose|DRUG: PXT3003 Intermediate Dose|DRUG: PXT3003 High Dose|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BIOEQUIVALENCE STUDY IN HEALTHY PARTICIPANTS COMPARING 4 MG AND 8 MG FESOTERODINE EXTENDED-RELEASE TABLETS (TOVIAZ™), MANUFACTURED AT ZWICKAU VERSUS FREIBURG
Status: COMPLETED
Conditions: Neurogenic Detrusor Overactivity
Interventions: DRUG: 4 mg Fesoterodine ER tablet from Zwickau|DRUG: 4 mg fesoterodine ER tablet from Freiburg|DRUG: 8 mg fesoterodine ER tablet from Zwickau|DRUG: 8 mg fesoterodine ER tablet from Freiburg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: 7% Hypertonic Saline for Acute Bronchiolitis
Status: COMPLETED
Conditions: Acute Bronchiolitis
Interventions: DRUG: Hypertonic saline and epinephrine|DRUG: Normal saline and epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Median Effective Dose of Dexmedetomidine in Elective Upper Limb Lidocaine Intravenous Regional Anesthesia
Status: COMPLETED
Conditions: Intravenous Drug Usage
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analyzing Retinal Microanatomy in ROP
Status: COMPLETED
Conditions: Retinopathy of Prematurity|Neurodevelopmental Disorders|Macular Edema
Interventions: DEVICE: Swept Source OCT|OTHER: Magnetic Resonance Imaging|OTHER: Scavenged blood collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Elastic Tape Relieves Symptoms and Improves Health-related Quality of Life in COPD (Chronic Obstructive Pulmonary Disease)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Elastic Tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Erbitux™ (Cetuximab) in Pediatric Patients With Refractory Solid Tumors
Status: COMPLETED
Conditions: Cancer|Refractory Solid Tumor
Interventions: DRUG: Cetuximab + Irinotecan|DRUG: Cetuximab + Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluating a New Knee-Ankle-Foot Brace to Improve Gait in Children With Movement Disorders
Status: RECRUITING
Conditions: Incomplete Spinal Cord Injury|Muscular Dystrophy|Spina Bifida|Cerebral Palsy
Interventions: DEVICE: EA-KAFO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Association Between Light Spectrum and Survival After Cataract Surgery
Status: COMPLETED
Conditions: Cataract|Age-related Cataract|Circadian Rhythm Disorders|Glaucoma|Age Related Macular Degeneration
Interventions: DEVICE: Blue-light filtering intraocular lens|DEVICE: Conventional intraocular lens
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of 2-dose Vaccination Regimen of Ad26.ZEBOV and MVA-BN-Filo in Infants
Status: COMPLETED
Conditions: Ebola Virus Disease
Interventions: BIOLOGICAL: Ad26.ZEBOV|BIOLOGICAL: MVA-BN-Filo|BIOLOGICAL: MenACWY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Bendamustine and Rituximab Induction Therapy and Maintenance Rituximab and Lenalidomide in Previously Untreated CLL/SLL
Status: COMPLETED
Conditions: Lymphoid Leukemia|Small Lymphocytic Lymphoma|Lymphoma, Non-Hodgkin
Interventions: DRUG: Bendamustine|DRUG: Rituximab|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between UBE and PETD for the Treatment of Lumbar Spinal Canal Stenosis
Status: ENROLLING_BY_INVITATION
Conditions: Lumbar Disc Herniation
Interventions: PROCEDURE: unilateral biportal endoscopy technique or percutaneous endoscopic transforaminal discectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Scleroderma Lung Study III - Combining Pirfenidone With Mycophenolate
Status: COMPLETED
Conditions: Scleroderma, Systemic|Interstitial Lung Disease
Interventions: DRUG: Pirfenidone (PFD)|DRUG: Placebo (Plac)|DRUG: Mycophenolate Mofetil (MMF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Brain, Behavior and Endocrine Effects of Transcutaneous Vagus Nerve Stimulation
Status: UNKNOWN
Conditions: Healthy
Interventions: DEVICE: Vagus nerve stimulation via tragus|DEVICE: Sham stimulation via earlobe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer
Status: NOT_YET_RECRUITING
Conditions: Biliary Tract Cancer
Interventions: DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Durvalumab|DRUG: Trastuzumab deruxtecan|DRUG: Rilvegostomig|DIAGNOSTIC_TEST: Agilent HercepTest™ mAb pharmDx|DIAGNOSTIC_TEST: Ventana PD-L1 SP263 assay
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of an Intensified Treatment With ACE-I,ATA II and Statins in Alport Syndrome
Status: COMPLETED
Conditions: Alport Syndrome
Interventions: DRUG: ACE I, ATA II and Statins|DRUG: Benazepril, Valsartan and Fluvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accelerated rTMS for Post-Stroke Apathy
Status: RECRUITING
Conditions: Apathy|Stroke Sequelae|Stroke (CVA) or TIA|Stroke/Brain Attack|Motivation|Abulia
Interventions: DEVICE: MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Alternative Dosing of Exemestane Before Surgery in Treating Postmenopausal Patients With Stage 0-II Estrogen Positive Breast Cancer
Status: COMPLETED
Conditions: Stage 0 Breast Cancer AJCC v6 and v7|Stage I Breast Cancer AJCC v7|Stage IA Breast Cancer AJCC v7|Stage IB Breast Cancer AJCC v7|Stage II Breast Cancer AJCC v6 and v7|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7
Interventions: DRUG: Exemestane|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|OTHER: Placebo Administration|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma
Status: UNKNOWN
Conditions: Sarcoma
Interventions: BIOLOGICAL: dactinomycin|DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: topotecan hydrochloride|DRUG: vincristine sulfate|DRUG: vinorelbine tartrate|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Neuromodulation Effect of Laser Acupuncture on Stress Urinary Incontinence
Status: UNKNOWN
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: Low Level Laser Therapy|OTHER: Pelvic floor muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Lactibiane Tolerance® to Treat Leaky Gut in Irritable Bowel Syndrome With Predominant Diarrhea (IBS-D)Patients
Status: COMPLETED
Conditions: IBS - Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Multistrain probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The iLet Introduction Study: A Feasibility Study of the iLet, a Fully Integrated Bihormonal Bionic Pancreas
Status: TERMINATED
Conditions: Diabetes Mellitus Type 1
Interventions: DEVICE: iPhone bionic pancreas|DEVICE: iLet bionic pancreas|DRUG: Xeris Xerisol glucagon|DRUG: Lilly glucagon|DEVICE: iLet infusion set|DEVICE: Contact Detach infusion set
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Understand the Effect of Multiple Ascending Doses of PF-07293893 in Healthy Adult Participants
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: PF-07293893|DRUG: Placebo|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intravenous Immunoglobulins for the Treatment of Covid-19 Patients: a Clinical Trial
Status: UNKNOWN
Conditions: Covid19
Interventions: BIOLOGICAL: intravenous immunoglobulin therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label, Randomized Phase I Study in Healthy Adults of the Safety and Immunogenicity of Prime-Boost Intervals With Monovalent Influenza Subunit Virion (H5N1) Vaccine, A/Indonesia/05/2005 (Sanofi Pasteur, Inc.) Administered Alone or Following Re...
Status: COMPLETED
Conditions: Influenza A Virus, H5N1 Subtype
Interventions: BIOLOGICAL: VRC-AVIDNA036-00-VP|BIOLOGICAL: Monovalent Influenza Subunit Virion (Inactive H5N1) Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sorafenib Plus 5-Azacitidine Initial Therapy of Patients With Acute Myeloid Leukemia (AML) and High Risk Myelodysplastic Syndrome (MS) With FLT3-ITD Mutation
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Azacytidine|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digital Versus Analog Pleural Drainage Following Pulmonary Resection
Status: COMPLETED
Conditions: Pulmonary Air Leak|Lobectomy|Wedge Resection|Segmentectomy
Interventions: DEVICE: Thopaz (Digital drainage)|DEVICE: Pleur Evac (Analogue drainage)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Management of Fracture Ankle in Adults With Uncontrolled Diabetes by Hind Foot Nail With Versus Without Joint Preparation , in Assiut University Hospital
Status: UNKNOWN
Conditions: Figure Out the Best Method of Fixation for Management of Patients With Diabetic Fracture Ankle
Interventions: OTHER: joint preparation|OTHER: without joint preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combined Therapy Using D-TACE, Gemcitabine and Cisplatin, and PD1 Antibody in Advanced and Unresectable Intrahepatic Cholangiocarcinoma
Status: RECRUITING
Conditions: Unresectable Intrahepatic Cholangiocarcinoma
Interventions: DRUG: Camrelizumab|DRUG: Gemcitabine Injection|DRUG: Cisplatin injection|DRUG: Cisplatin-Eluting Beads|PROCEDURE: D-TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Endovascular Treatment of Subjects With Stenotic or Restenotic Lesions of the Common Femoral Artery With the Supera Vascular Mimetic Implant Compared to Surgical Common Femoral Artery Endarterectomy
Status: RECRUITING
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: Supera Peripheral Stent System treatment group|PROCEDURE: Endarterectomy treatment group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Phase 2 Trial of a Steroid-Free, CNI-Free, Belatacept-Based Immunosuppressive Regimen
Status: TERMINATED
Conditions: Primary Renal Allograft Candidate|Kidney Transplantation
Interventions: BIOLOGICAL: Anti-thymocyte Globulin (Rabbit)|BIOLOGICAL: belatacept|DRUG: methylprednisolone|BIOLOGICAL: basiliximab|DRUG: mycophenolate mofetil|DRUG: tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Application in Traumatic Brain Edema Between EIT and Non-invasive ICP Monitoring
Status: UNKNOWN
Conditions: Brain Electrical Impedance;|Non-invasive Intracranial Pressure
Interventions: DEVICE: EIT monitoring|DEVICE: non-invasive ICP monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Kinesio Taping on Chronic Nonspecific Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Functional elastic tape tensioned|OTHER: Functional elastic tape non-tensioned|OTHER: Rigid Tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety and Tolerability of CC-486 (ONUREG®, Oral Azacitidine) in Combination Therapy in Participants With Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: CC-486|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral Encochleated Amphotericin B (CAMB) in the Treatment of Fluconazole-Resistant Vulvovaginal Candidiasis
Status: WITHDRAWN
Conditions: Vulvovaginal Candidiases|Yeast Infection|Vulvovaginitis|Yeast Infection Vaginal|Candidiasis, Vulvovaginal
Interventions: DRUG: Oral Encochleated Amphotericin B (CAMB)|DRUG: Oral Encochleated Amphotericin B (CAMB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Potential Efficacy of SYN117 in Cocaine Dependent Volunteers
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: SYN117 Placebo|DRUG: SYN117 80 mg|DRUG: SYN117 160 mg|DRUG: Cocaine 10mg|DRUG: Cocaine 20mg|DRUG: Cocaine 40mg|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Prostate Cancer Imaging According to Various Metastatic Risks
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: 68Ga-PSMA-617 PET/CT|DRUG: 68Ga-RM2 PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Visual Dyslexia Remediation Protocols - Dyslexia REMEDIATION
Status: RECRUITING
Conditions: Dyslexia
Interventions: BEHAVIORAL: visual stimulation with I pad|BEHAVIORAL: visual stimulation with lamp
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Proof-of-Concept Study Assessing NEO6860 in Osteoarthritis Pain
Status: COMPLETED
Conditions: Pain|Osteoarthritis of the Knee
Interventions: DRUG: NEO6860|DRUG: NEO6860 placebo|DRUG: Naproxen|DRUG: Naproxen placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Oxaliplatin and 5-fluorouracil Followed by FUDR for Unresectable Colorectal Liver Metastases
Status: COMPLETED
Conditions: Colorectal Liver Metastases
Interventions: DRUG: Drug: 5-FU|DRUG: Drug: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closed-loop Control of Glucose Levels (Artificial Pancreas) for 15 Weeks in Adolescents and Adults With Type 1 Diabetes
Status: WITHDRAWN
Conditions: Type 1 Diabetes
Interventions: OTHER: 15-week intervention with sensor-augmented pump|OTHER: 15-week intervention with single-hormone closed-loop|OTHER: 15-week intervention with dual-hormone closed-loop|DEVICE: Insulin pump|DEVICE: Continuous glucose monitoring system|DRUG: Insulin|DRUG: Glucagon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy With or Without Optional Tamoxifen in Treating Women With Ductal Carcinoma in Situ
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: tamoxifen citrate|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Randomized Clinical Trial of Intravenous Lipids and Cholestasis
Status: COMPLETED
Conditions: Parenteral Nutrition Associated Cholestasis
Interventions: DRUG: intravenous lipid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Chemotherapy Combination With Autologous Cytokine-Induced Killer Cell Immunotherapy to Treat Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer|Squamous Cell Carcinoma
Interventions: BIOLOGICAL: CIK cell|DRUG: Gemcitabine Injection|DRUG: Cisplatin injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anesthesia for Pars Plana Vitrectomy (PPV) With Insulin Needle
Status: COMPLETED
Conditions: Retinal Disorders
Interventions: DEVICE: needle|DEVICE: needle|PROCEDURE: Pars Plana Vitrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Safety and Efficacy of Keppra After Conversion to Mono-therapy in Subjects With Partial Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Levetiracetam (Keppra)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritional Supplementation in Reducing Complications in Patients With Locally Advanced Esophageal Cancer Undergoing Chemotherapy, Radiation Therapy, and/or Surgery
Status: WITHDRAWN
Conditions: Clinical Stage III Esophageal Adenocarcinoma AJCC v8|Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC v8|Pathologic Stage III Esophageal Adenocarcinoma AJCC v8|Pathologic Stage III Esophageal Squamous Cell Carcinoma AJCC v8|Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IIIA Esophageal Squamous Cell Carcinoma AJCC v8|Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IIIB Esophageal Squamous Cell Carcinoma AJCC v8|Postneoadjuvant Therapy Stage III Esophageal Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage III Esophageal Squamous Cell Carcinoma AJCC v8|Postneoadjuvant Therapy Stage IIIA Esophageal Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IIIA Esophageal Squamous Cell Carcinoma AJCC v8|Postneoadjuvant Therapy Stage IIIB Esophageal Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IIIB Esophageal Squamous Cell Carcinoma AJCC v8|Resectable Mass
Interventions: DIETARY_SUPPLEMENT: Nutritional Supplement Drink|DIETARY_SUPPLEMENT: Nutritional Supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sufentanil Sublingual Tablet System for Postoperative Pain Management After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Sufentanil Sublingual Tablet|DRUG: Oxycodone oral tablet and oxycodone extended-release oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Examine the Effects of Oral Fenretinide
Status: NOT_YET_RECRUITING
Conditions: Dengue
Interventions: DRUG: ISLA101|DRUG: Dengue 1 Live Virus Human Challenge (DENV-1-LVHC)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Randomized, Double-blind, Placebo-controlled Study of the Combination Therapy of T-614 and Methotrexate in Rheumatoid Arthritis Patients With an Inadequate Response to Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: T-614|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label, Multicenter, Phase II Study of LDK378 in Patients With Non-small Cell Lung Cancer Harboring ROS1 Rearrangement
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: DRUG: LDK378
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LBH589 Alone or in Combination With Erythropoietin Stimulating Agents (ESA) in Patients With Low or Int-1 Risk Myelodysplastic Syndromes (MDS)
Status: TERMINATED
Conditions: Myelodysplastic Syndrome (MDS)
Interventions: DRUG: LBH589|DRUG: Epoetin Alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women
Status: COMPLETED
Conditions: Vasomotor Symptoms|Menopausal Symptoms
Interventions: DRUG: Estetrol oral tablet|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sanofi H1N1 Influenza Vaccine Administered at Different Dose Levels With and Without AS03 Adjuvant in Healthy Adult and Elderly Populations
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: AS03|BIOLOGICAL: Influenza Virus Vaccine, Monovalent A/H1N1 A/California/7/2009 NYMC X-179A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Two Different Low-level Laser Intensity Protocols on the Healing of Palatal Wounds
Status: COMPLETED
Conditions: Palatal Wound
Interventions: PROCEDURE: Low Level Laser Therapy|DEVICE: GaAlAs laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of XNW5004 Tablet in Combination With KEYTRUDA® (Pembrolizumab) in Subjects With Advanced Solid Tumors Who Failed Standard Treatments (KEYNOTE F19)
Status: RECRUITING
Conditions: Carcinoma|Squamous Cell Carcinoma of Head and Neck|Urothelial Carcinoma|Prostate Cancer|Small-cell Lung Cancer|Non-small Cell Lung Cancer|Cervical Cancer|Other Solid Tumors
Interventions: DRUG: XNW5004|DRUG: KEYTRUDA® (pembrolizumab) 25 mg/mL Solution for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Osteopathic Manipulative Treatment on Length of Stay in Preterms
Status: COMPLETED
Conditions: Prematurity
Interventions: OTHER: osteopathic manipulative treatment|PROCEDURE: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Double-Blind, Randomized, Single Dose Escalation Safety Study of Intra-articular OP-1 in Subjects With Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: Intra-articular Injection of OP-1 to affected knee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Etanercept Use in Patients With Moderate to Severe Rheumatoid Arthritis Who Have Lost Response to Adalimumab
Status: TERMINATED
Conditions: Moderate to Severe Rheumatoid Arthritis
Interventions: BIOLOGICAL: Etanercept|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regional Anticoagulation of Dialysis Circuits With a Calcium-free Citrate-containing Dialysate
Status: COMPLETED
Conditions: Hemodialysis Complication|Bleeding
Interventions: COMBINATION_PRODUCT: anticoagulation of the dialysis circuit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of New Intensive Treatment Regimen for Severe Nontuberculous Mycobacterial Pulmonary Disease
Status: NOT_YET_RECRUITING
Conditions: Nontuberculous Mycobacterial Lung Disease
Interventions: DRUG: New regimen(BdqCfzLzd+XY)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dexamethasone Implant in Hard Exudate Complicated With Diabetic Macular Edema
Status: UNKNOWN
Conditions: Diabetes Mellitus|Macular Edema|Retinal Exudates and Deposits
Interventions: DRUG: Intravitreal dexamethasone 0.7mg implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
Status: RECRUITING
Conditions: Anxiety Disorders|Major Depressive Disorder
Interventions: BEHAVIORAL: Attention Bias Modification Training|DRUG: Fluoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Domestic Tenofovir Tablets in Chinese Patients With Chronic Hepatitis B
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: Domestic Tenofovir Disoproxil Fumarate Tablets|DRUG: Tenofovir Disoproxil Fumarate Tablets of Gilead
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pneumothorax After CT-guided Lung Biopsy: Standard vs Autologous Blood Patching
Status: UNKNOWN
Conditions: Pneumothorax|Biopsy Wound
Interventions: OTHER: Autologous blood patch injection (ABPI)|OTHER: CT-guided core needle biopsy (CNB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Oral Infections: Dietary Regulation of Local and Systemic Inflammatory Responses
Status: COMPLETED
Conditions: Periodontal Attachment Loss
Interventions: DIETARY_SUPPLEMENT: Omega-3 Fatty acid (with SRP or OHI)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of an Capsular Tension Ring on the Rotation of an Intraocular Lens (Aspira®-aA Also Known as MC 6125 AS)
Status: COMPLETED
Conditions: Cataract
Interventions: PROCEDURE: cataract surgery|DEVICE: intraocular lens (MC 6125 AS)|DEVICE: capsular tension ring (CTR 13/11)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Metabolic Imaging in Carotid Atherosclerosis
Status: COMPLETED
Conditions: Atherosclerosis|Stroke
Interventions: OTHER: USPIO (ferumoxytol)-enhanced MRI scan|RADIATION: 18f-Fluoride PET/CT scan|RADIATION: 18F-Flurodeoxyglucose PET/CT scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Serrated Lesions Detection With Endocuff-assisted Colonoscopy
Status: COMPLETED
Conditions: Serrated Lesion|Adenoma|Colorectal Cancer
Interventions: DEVICE: Endocuff colonoscopy|DEVICE: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Effectiveness of Pillar Palatal Implants to Treat Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Pillar Palatal Implants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Carboplatin+Nab-paclitaxel, Plus Trastuzumab (HER2+) or Bevacizumab (HER2-) in the Neoadjuvant Setting
Status: COMPLETED
Conditions: Breast Cancer|HER2-negative Breast Cancer|HER2-positive Breast Cancer|Recurrent Breast Cancer|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: DRUG: Carboplatin|DRUG: paclitaxel albumin-stabilized nanoparticle formulation|DRUG: bevacizumab|DRUG: trastuzumab|PROCEDURE: magnetic resonance imaging|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protein, Fiber, and Metabolic Syndrome - The PROFIMET Study
Status: COMPLETED
Conditions: Overweight|Obesity|Metabolic Syndrome
Interventions: OTHER: control diet, supported by dietary supplement twice daily|OTHER: high cereal fiber diet, supported by dietary supplement twice daily|OTHER: high protein diet, supported by dietary supplement twice daily|OTHER: diet moderately high both in cereal fiber and protein, supported by dietary supplement twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Amplitude and Rate of Intrinsic Feedback During Treadmill Training for Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease|Treadmill
Interventions: BEHAVIORAL: rate group|BEHAVIORAL: magnitude treadmill group|BEHAVIORAL: regular treadmill walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging CCR2 Receptors With 64Cu-DOTA-ECL1i in Head and Neck Cancer
Status: TERMINATED
Conditions: Head and Neck Cancer
Interventions: DRUG: 64Cu-DOTA-ECL1i
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Efficacy and Safety Study of Decitabine in Participants With Myelodysplastic Syndrome (MDS)
Status: COMPLETED
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Controlled-perturbation Gait Training on Gait Rehabilitation and Fear of Falling in Individuals With Gait Impairments
Status: UNKNOWN
Conditions: Cerebrovascular Disorders|Peripheral Nervous System Diseases|Musculoskeletal Diseases|Joint Diseases
Interventions: OTHER: perturbation training|OTHER: balance exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Bulb Aspirator to a Nasal Oral Aspirator in the Treatment of Bronchiolitis
Status: COMPLETED
Conditions: Bronchiolitis|Aspirator
Interventions: DEVICE: NeilMed Naspira
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aspirin vs Clopidogrel After TAVR
Status: RECRUITING
Conditions: Severe Aortic Stenosis
Interventions: DRUG: Aspirin single antiplatelet therapy|DRUG: Clopidogrel single antiplatelet therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Cancer Treatments on Speech Perception in Noise, Cognition, and Hearing-Related Quality of Life
Status: NOT_YET_RECRUITING
Conditions: Cancer|Hearing Loss Ototoxic|Cognitive Decline|Quality of Life
Interventions: OTHER: Chemotherapy, chemoradiation, radiation therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases
Status: NOT_YET_RECRUITING
Conditions: Mitochondrial Diseases|Maternally Inherited Diabetes and Deafness (MIDD)|Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)|Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation
Interventions: DRUG: Sonlicromanol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 3-Arm Study Comparing the Efficacy of Anti-Reflux Reconstruction Protocols After Laparoscopic Proximal Gastrectomy
Status: COMPLETED
Conditions: Anti-Reflux Alimentary Reconstruction|Laparoscopic Proximal Gastrectomy|Siewert Type II/III Adenocarcinoma of the Esophagogastric Junction
Interventions: PROCEDURE: Anti-Reflux Alimentary Reconstruction After Laparoscopic Proximal Gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase II, Open-Label, Study of Subcutaneous Canakinumab, an Anti-IL-1β Human Monoclonal Antibody, for Patients With Low or Int-1 Risk IPSS/IPSS-R Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia
Status: RECRUITING
Conditions: Chronic Myelomonocytic Leukemia|Myelodysplastic Syndrome|Recurrent Chronic Myelomonocytic Leukemia|Recurrent Myelodysplastic Syndrome|Refractory Chronic Myelomonocytic Leukemia|Refractory Myelodysplastic Syndrome
Interventions: BIOLOGICAL: Canakinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: iDTECT Blood Performance for the Identification of Viral or Bacterial Pathogens in Febrile Neutropenic Patients
Status: UNKNOWN
Conditions: Febrile Neutropenia|Acute Leukemia|Stem Cell Transplantation|Infection
Interventions: DIAGNOSTIC_TEST: iDTECT Blood
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of 980nm Diode Laser on Postoperative Pain and Root Canal Disinfection in Endodontic Retreatment Cases
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: RADIATION: 980 nm diode laser|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Use of an Online Learning and Consent Platform in Infertility Treatment
Status: COMPLETED
Conditions: Patient Satisfaction
Interventions: OTHER: EngagedMD online learning platform
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of Metabolically Armed CD19 CAR-T Cells (Meta10- 19) in the Treatment of r/r B-ALL Clinical Research
Status: RECRUITING
Conditions: B-cell Acute Lymphoblastic Leukemia
Interventions: DRUG: Metabolically Armed CD19 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First-in-Human Study of XSTEM-OA in Patients With Knee Osteoarthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: BIOLOGICAL: XSTEM-OA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Status After Removal of Skull Base Meningioma
Status: RECRUITING
Conditions: Meningioma|Skull Base Meningioma|Frontal Meningioma|Temporal Meningioma|Cognitive Impairment|Cognitive Decline|Post-Surgical Cognition
Interventions: OTHER: Long-term Cognitive testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study LY2228820 for Recurrent Ovarian Cancer
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Cancer
Interventions: DRUG: LY2228820|DRUG: Carboplatin|DRUG: Placebo|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intraarticular Steroids on Bone Turnover in Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Methylprednisolone and Lidocaine|DRUG: Methylprednisolone and Lidocaine|DRUG: Placebo and Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 1 Study of Duvelisib in Patients With Advanced Hematologic Malignancies
Status: TERMINATED
Conditions: Hematologic Malignancies
Interventions: DRUG: IPI-145 (duvelisib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zalutumumab in Non-Small Cell Lung Cancer (NSCLC) Patients Refractory to Tyrosine Kinase Inhibitors
Status: WITHDRAWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: zalutumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Cystic Fibrosis
Interventions: DRUG: VX-121/TEZ/D-IVA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study With 500 mg QD of TRO19622 vs Placebo in Patients With Painful Peripheral Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathy
Interventions: DRUG: Experimental|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Genotype-based Warfarin Initiation in Patients With Mechanical Prosthetic Heart Valve
Status: UNKNOWN
Conditions: Anticoagulation Treatment Overdose|Heart Valve Diseases
Interventions: OTHER: Genotype-based Warfarin Initiation model|OTHER: clinical factor-based warfarin initiation model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: PROMOTE: The Effect of a Six Week Probiotic or Prebiotic Supplementation on Wellbeing of Young Adults.
Status: NOT_YET_RECRUITING
Conditions: Wellbeing|Healthy
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Prebiotic|DIETARY_SUPPLEMENT: Maltodextrin (Corn)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: BIANCA-SC: A Study of the Efficacy, Safety, and Tolerability of Blisibimod in Addition to Methotrexate During Induction of Remission in Subjects With ANCA-Associated Small Vessel Vasculitis
Status: WITHDRAWN
Conditions: Granulomatosis With Polyangiitis|Microscopic Polyangiitis
Interventions: DRUG: Blisibimod|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sorafenib in Previously Treated Advanced Hepatocellular Carcinoma: SOPT Study
Status: ENROLLING_BY_INVITATION
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy for High Risk/Relapsed CD19+ Acute Lymphoblastic Leukaemia, B-cell Non-Hodgkin's Lymphoma (B-NHL) and Chronic Lymphocytic Leukaemia (CLL)/ Small Lymphocytic Lymphoma (SLL) Using CAR T-cells to Target CD19
Status: RECRUITING
Conditions: Leukemia, Lymphoblastic, Acute, Lymphoma
Interventions: BIOLOGICAL: CD19CAT-41BBZ CAR T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Development of a Guidance of Combined HA and ESWT for Non-calcific Rotator Cuff Lesions Without Complete Tear
Status: UNKNOWN
Conditions: Rotator Cuff Lesions
Interventions: OTHER: HA only|OTHER: ESWT once|OTHER: ESWT twice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Paravertebral Block for Mastectomy With Immediate Reconstruction
Status: NOT_YET_RECRUITING
Conditions: Postoperative Pain
Interventions: PROCEDURE: Paravertebral block|PROCEDURE: Usual analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Added Value of Metamizole to Standard Postoperative Treatment After Ambulant Shoulder Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Analgesia|Surgery
Interventions: DRUG: Metamizole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Clevidipine Butyrate Injectable Emulsion in the Treatment of Hypertensive Emergency and Sub-emergency
Status: NOT_YET_RECRUITING
Conditions: Hypertensive Emergency
Interventions: DRUG: Clevidipine Butyrate Injectable Emulsion|DRUG: Cleviprex®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anodal Transcranial Direct Current Stimulation of the Visual Cortex Versus Sham Stimulation in the Episodic Migraine
Status: WITHDRAWN
Conditions: Sporadic Migraine
Interventions: DEVICE: Cefaly tDCS|DEVICE: sham Cefaly tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of MEDI3506 in Adults With Uncontrolled Moderate-to-severe Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: MEDI3506|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electronic Health Record-Enabled Evidence-Based Smoking Cessation Quality Improvement Implementation Program
Status: ACTIVE_NOT_RECRUITING
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: ELEVATE enhancement to electronic health record (EHR) to improve cessation counseling offer|BEHAVIORAL: ELEVATE enhancement to electronic health record (EHR) to improve smoking cessation medication offer|BEHAVIORAL: Data Driven Feedback reports
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study in Moderate to Severe Rheumatoid Arthritis Participants
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Placebo|DRUG: Baricitinib|DRUG: cDMARD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Change in Permeability of the Small Intestine After Treatment With Gluten
Status: COMPLETED
Conditions: Gastrointestinal Disorders
Interventions: DIETARY_SUPPLEMENT: Gluten Healthy|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC