pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Effect of Anodal tDCS on Motor Learning in Multiple Sclerosis
Status: COMPLETED
Conditions: Anodal tDCS|Recruitment Curves
Interventions: DEVICE: Transcranial Direct Current Stimulation (tDCS) (Neuroconn DC-stimulator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Ranibizumab for the Treatment of Choroidal Neovascularization in Ocular Histoplasmosis Syndrome
Status: UNKNOWN
Conditions: Ocular Histoplasmosis Syndrome
Interventions: DRUG: ranibizumab|DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Consuming Plant Sterols on Endothelial Function and Blood Pressure
Status: COMPLETED
Conditions: Cardiovascular Diseases|Endothelial Dysfunction|Metabolic Syndrome|Diet Modification
Interventions: DIETARY_SUPPLEMENT: plant sterols|OTHER: healthy diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Gemcitabine in Combination With Pemetrexed Long Term Infusion in the Treatment of Pretreated Metastatic Colorectal Cancer Patients
Status: COMPLETED
Conditions: Colorectal Cancer Metastatic
Interventions: DRUG: Arm A : Gemcitabine + Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega 3 Fatty Acid Efficiency for Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting
Status: TERMINATED
Conditions: Ischemic Heart Disease|Atrial Fibrillation
Interventions: DRUG: Omega-3 fish oil emulsion (Omegaven)|DRUG: Intralipid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation and WBV in Inflammatory Markers, Strength and Body Composition in Old Patients With COPD
Status: UNKNOWN
Conditions: COPD|Aging
Interventions: DIETARY_SUPPLEMENT: Vitamin D|OTHER: whole body vibration (WBV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Facial Erythema Associated With Rosacea
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: CD07805/47 Gel|DRUG: Vehicle Gel|DRUG: CD07805/47 Gel|DRUG: CD07805/47 Gel|DRUG: Vehicle Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Bone Marrow Concentrate in Elective Tranforaminal Lumbar Interbody Fusion Surgery
Status: UNKNOWN
Conditions: Bone Marrow|Spinal Fusion
Interventions: OTHER: Transforaminal lumbar interbody fusion with local bone graft and intraoperative bone marrow concentration|OTHER: Transforaminal lumbar interbody fusion with local bone graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Omitting CTV for Locally Advanced NSCLC Responded to Immunotherapy and Chemotherapy
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer|Locally Advanced|Radiotherapy|Immunotherapy
Interventions: RADIATION: CTV omitted or delineated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Wound Healing Between MedCu Dressings With Copper Oxide and Negative Pressure Wound Therapy Treatment
Status: COMPLETED
Conditions: Wounds and Injuries|Negative Pressure Therapy|Diabetic Foot Ulcer
Interventions: DEVICE: MedCu wound dressings with copper oxide (COD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Metabolomics for the Identification of Endometrial Biomarkers for IRPL and RIF After in Vitro Fertilization
Status: UNKNOWN
Conditions: Recurrent Pregnancy Loss|Recurrent Implantation Failure
Interventions: OTHER: metabolomics analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Investigate Safety, Tolerability and Pharmacokinetics of AZD2423 Multiple Doses in Healthy Japanese Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD2423|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hashtag HPV: HPV Vaccine Twitter Education Program
Status: ACTIVE_NOT_RECRUITING
Conditions: Human Papilloma Virus|Vaccine-Preventable Diseases
Interventions: OTHER: HPV Twitter Education Program - Narrative|OTHER: HPV Twitter Education Program - Non-Narrative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect and Safety of Flecainide and Metoprolol Versus Metoprolol Alone to Suppress Ventricular Arrhythmias in Arrhythmic Mitral Valve Prolapse
Status: RECRUITING
Conditions: Mitral Valve Prolapse|Ventricular Arrhythmias and Cardiac Arrest
Interventions: DRUG: Flecainide|DRUG: Metoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Pharmacokinetic Study of Oral Ixazomib Plus Lenalidomide and Dexamethasone in Adult Asian Participants With Relapsed and/or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Ixazomib|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shockwave Effectiveness in Myofascial Pain of the Upper Trapezius Muscle
Status: COMPLETED
Conditions: Myofascial Pain Syndrome
Interventions: DEVICE: F-ESWT Group|DEVICE: sham F-ESWT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: One Step Versus Two Step Approach for Gestational Diabetes Mellitus Screening
Status: UNKNOWN
Conditions: Gestational Diabetes
Interventions: DIAGNOSTIC_TEST: GDM screening with 75 g 2 hour GTT|DIAGNOSTIC_TEST: GDM screening with two step approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Efficacy Between Combination of Amitriptyline-propranolol and Pizotifen for Migraine Prophylaxis.
Status: ACTIVE_NOT_RECRUITING
Conditions: Migraine
Interventions: DRUG: Pizotifen|DRUG: Amitriptyline-propranolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Endoscopic Direct-PEG Placement in Patients Unable to Undergo Pull-PEG Procedure
Status: COMPLETED
Conditions: Head and Neck Neoplasm|Gastrostomy|Esophageal Stenosis and Obstruction
Interventions: PROCEDURE: PEG placement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-PD-1 Alone or Combined With Autologous Cell Therapy in Advanced NSCLC
Status: COMPLETED
Conditions: Lung Cancer|Neoplasms
Interventions: BIOLOGICAL: Anti-PD-1 plus DC-CIK|BIOLOGICAL: Anti-PD-1 alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Removable Complete Denture Over One Implant in the Lower Jaw on Hearing Ability
Status: RECRUITING
Conditions: Hearing
Interventions: OTHER: Overdenture|OTHER: Complete Denture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maitland Thoracic Mobilization Versus Mulligan Thoracic Mobilization in Kyphotic Patients With Shoulder Impingement Syndrome
Status: COMPLETED
Conditions: Shoulder Impingement Syndrome|Kyphosis Thoracic
Interventions: OTHER: Maitland mobilization for thoracic spine|OTHER: Mulligan thoracic sustained natural apophyseal glide (SNAGS)|OTHER: Traditional exercise management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Management Radiodermatitis in Patients With Breast or Head and Neck Cancer
Status: COMPLETED
Conditions: Radiodermatitis
Interventions: OTHER: Chamomilla recutita gel|DRUG: Urea cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Randomized Comparison of ExoSeal® and Angio-Seal Vascular Closure Devices: The CLOSE-UP II Trial
Status: COMPLETED
Conditions: Coronary Disease
Interventions: DEVICE: Exoseal closure device|DEVICE: Angioseal closure device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of a Probiotic in Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DIETARY_SUPPLEMENT: probiotic L sakei KCTC 10755BP|DIETARY_SUPPLEMENT: microcrystalline cellulose (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cellular Adoptive Immunotherapy in Treating a Patient Who Has Undergone a Donor Stem Cell Transplant for Breast Cancer That Has Spread to the Lung
Status: COMPLETED
Conditions: Breast Cancer|Metastatic Cancer
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: therapeutic tumor infiltrating lymphocytes|BIOLOGICAL: trastuzumab|DRUG: paclitaxel|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Role of Sweetness in Glucose Regulation
Status: UNKNOWN
Conditions: Obesity
Interventions: OTHER: Control - Inhibition|OTHER: Experimental I- Inhibition|OTHER: Experimental II- Inhibition|OTHER: Control- Stimulation|OTHER: Experimental I- Stimulation|OTHER: Experimental II- Stimulation|OTHER: Sensory Evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Normal Pressure Hydrocephalus Treatment by Acetazolamide
Status: TERMINATED
Conditions: Motor Condition as Measured by Quantified Scale|Cognitive Investigation
Interventions: DRUG: Acetazolamide|DRUG: sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Elastography to Predict Development of SOS
Status: TERMINATED
Conditions: Bone Marrow Transplant Complications|Sinusoidal Obstruction Syndrome|Veno-occlusive Disease|Stem Cell Transplant Complications
Interventions: DIAGNOSTIC_TEST: Ultrasound Examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: NTRK Gene Fusion - Positive Advanced or Recurrent Solid Tumors, a Rare Cancer Caused by Specific Changes in the Genes
Status: RECRUITING
Conditions: Advanced or Recurrent Solid Tumor Harboring an NTRK Gene Fusion
Interventions: DRUG: Larotrectinib (Vitrakvi, BAY2757556)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Pharmacokinetics of Clindamycin in Pediatric Subjects With BMI ≥ 85th Percentile
Status: COMPLETED
Conditions: Bacterial Infections|Obesity
Interventions: DRUG: Clindamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Two- Versus Three-antibiotic Therapy for Pulmonary Mycobacterium Avium Complex Disease
Status: RECRUITING
Conditions: Mycobacterium Avium Complex|Nontuberculous Mycobacterium Infection
Interventions: DRUG: Azithromycin|DRUG: Ethambutol|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STaged Interventional Strategies for Acute ST-seGment Elevation Myocardial Infarction Patient With Multi-vessel Disease（STAGED）
Status: RECRUITING
Conditions: STEMI|Multi Vessel Coronary Artery Disease|Percutaneous Coronary Intervention
Interventions: PROCEDURE: In-hospital staged PCI|PROCEDURE: Out-hospital staged PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Neurovascular Coupling in Glaucoma Patients and Healthy Subjects
Status: UNKNOWN
Conditions: Glaucoma, Open-Angle|Normal Tension Glaucoma|Ocular Hypertension
Interventions: DEVICE: Fourier Domain Doppler Optical Coherence Tomography (FDOCT)|DEVICE: Dynamic Vessel Analyzer (DVA)|DEVICE: Pattern Electroretinography (pERG)|DEVICE: Optical coherence tomography (OCT)|DEVICE: Laser Speckle Flowgraphy (LSFG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: High-intensity Training for Improving Physical Performance of Aged Women
Status: COMPLETED
Conditions: Aging|Healthy|Cardiovascular Risk Factor|Physical Activity
Interventions: OTHER: Experimental: High-intensity interval training group|OTHER: Experimental: Moderate-intensity interval training group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Detection and Quantification of Atrial Fibrillation in High-risk Patients Using a Smartwatch Wearable (Apple Watch)
Status: ENROLLING_BY_INVITATION
Conditions: Atrial Fibrillation|Wearable Electronic Devices
Interventions: DEVICE: Apple Watch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Flurbiprofen Tape for Treatment of Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: DRUG: Placebo Tape (Arm 1)|DRUG: Flurbiprofen Tape (Arm 2)|DRUG: Placebo Tape (Arm 3)|DRUG: Flurbiprofen Tape (Arm 4)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aerobic Exercise Program Followed by Cold Water Immersion: Effects on Arthritis Patients Arterial Stiffness
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Cryotherapy Effect|Physical Activity
Interventions: OTHER: Exercise followed cold water immersion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of the Brand-name Latanoprost and One of Its Generic Version in Primary Open Angle Glaucoma and Ocular Hypertension
Status: TERMINATED
Conditions: Primary Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Generic latanoprost|DRUG: Brand-name latanoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients With Pulmonary Arterial Hypertension (PAH)
Status: TERMINATED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Bosentan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LBH589 in Refractory Myelodysplastic Syndromes (MDS)
Status: TERMINATED
Conditions: Myelodysplastic Syndromes (MDS)
Interventions: DRUG: Panobinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cooled RF Lesion MRI Characteristics
Status: UNKNOWN
Conditions: Arthritis;Lumbosacral|Osteo Arthritis Knee|Sacroiliitis|Hip Osteoarthritis|Arthritis, Degenerative
Interventions: DEVICE: Cooled radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of the Specificity of Serological Tests for Human African Trypanosomiasis
Status: COMPLETED
Conditions: Human African Trypanosomiasis|Sleeping Sickness|Trypanosoma Brucei Gambiense; Infection|West African Sleeping Sickness
Interventions: DIAGNOSTIC_TEST: Serological field test for HAT|DIAGNOSTIC_TEST: malaria rapid test|DIAGNOSTIC_TEST: Immunologic laboratory tests|DIAGNOSTIC_TEST: Molecular laboratory tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Stem Cell Transplant From Donors After Alpha Beta Cell Depletion in Children and Young Adults
Status: RECRUITING
Conditions: Hematologic Diseases
Interventions: BIOLOGICAL: Allogeneic Stem Cell Transplant|DEVICE: CliniMACS TCR α/β Reagent Kit and CliniMACS CD19
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telehealth Outreach for Chronic Back Pain
Status: COMPLETED
Conditions: Pain|Back Pain
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy-Psychologist-Delivered|BEHAVIORAL: Supportive Psychotherapy-Psychologist-Delivered|BEHAVIORAL: Cognitive Behavioral Therapy Nurse-Delivered|BEHAVIORAL: Supportive Psychotherapy-Nurse-Delivered
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LymphoPilot Test for Limb Lymphedema
Status: TERMINATED
Conditions: Lymphedema, Secondary|Lymphedema of Upper Limb|Lymphedema Arm|Lymphedema of Leg|Lymphedema, Lower Limb
Interventions: DEVICE: LymphoPilot
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Pemetrexed Disodium/Observation in Treating Patients W/ Malignant Pleural Mesothelioma w/Out Progressive Disease After 1st Line Chemotherapy
Status: COMPLETED
Conditions: Malignant Mesothelioma
Interventions: DRUG: pemetrexed disodium|OTHER: clinical observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer
Status: RECRUITING
Conditions: NSCLC|HNSCC|Melanoma|Metastatic Cancer|Advanced Solid Tumor|Advanced Cancer
Interventions: DRUG: CJRB-101|DRUG: Pembrolizumab injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Advanced Diffusion MRI to Differentiate Tumor Recurrence From Pseudoprogression in Patients With Glioblastoma and Brain Metastases
Status: RECRUITING
Conditions: Glioblastoma (GBM)
Interventions: DIAGNOSTIC_TEST: Advanced diffusion-weighted MRI (ADW-MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ph 2 Trial of ADI PEG 20 Plus Concurrent Transarterial Chemoembolization (TACE) Vs TACE Alone in Patients With Unresectable Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Unresectable Hepatocellular Carcinoma
Interventions: DRUG: ADI-PEG 20|DRUG: Transarterial chemoembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D Supplementation in Live Birth Rate of in Vitro Fertilization Outcome
Status: RECRUITING
Conditions: Infertility
Interventions: DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Three Treatment of Chronic Obstructive Pulmonary Disease Patients
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Budesonide/Formoterol combination 160/4.5 mcg, 2 inhalations bid|DRUG: Tiotropium 18 mcg capsule inhaled once daily + Budesonide|DRUG: Formoterol/Tiotropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Cognitive Bias Modification RCT for Aggression
Status: UNKNOWN
Conditions: Intermittent Explosive Disorder
Interventions: BEHAVIORAL: Cognitive Bias Modification|BEHAVIORAL: Cognitive Bias Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid for the Control of Blood Loss at Elective Cesarean Section
Status: COMPLETED
Conditions: Cesarean Section Complications
Interventions: DRUG: normal saline|DRUG: 1gm tranexamic acid|DRUG: 0.5 gm tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Therapy of Anthracyclines for Children With Nephroblastoma
Status: NOT_YET_RECRUITING
Conditions: 0.5-14 Year Old Children With Nephroblastoma
Interventions: DRUG: Vincristine|DRUG: Oxytetracycline/ Cyclophosphamide|DRUG: Liposomal doxorubicin|DRUG: Doxorubicin|DRUG: Pharmorubicin|DRUG: Pirarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect Spinal Orthosis on Sagittal and Frontal Parameters in Scoliosis
Status: NOT_YET_RECRUITING
Conditions: Adolescent Idiopathic Scoliosis
Interventions: BIOLOGICAL: spinal orthoses
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Stop Addiction Stigma
Status: COMPLETED
Conditions: Hematopoietic and Lymphatic System Neoplasm|Malignant Solid Neoplasm
Interventions: BEHAVIORAL: Assessment|OTHER: Educational Activity|OTHER: Educational Activity|OTHER: Educational Activity|OTHER: Educational Activity|OTHER: Educational Activity|OTHER: Educational Activity|OTHER: Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: To Compare Cemented Versus Screw-retained Implant-supported Single Crowns With Customized Zirconia Abutments
Status: COMPLETED
Conditions: Implant-supported Single Crowns
Interventions: PROCEDURE: Cemented crowns|PROCEDURE: Screw-retained crowns
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neurophysiology of Fibromyalgia
Status: NOT_YET_RECRUITING
Conditions: Fibromyalgia
Interventions: DEVICE: Active Repetitive Transcranial Magnetic Stimulation (rTMS)|DEVICE: Sham Repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fructose Rich Diet and Endothelial Function
Status: COMPLETED
Conditions: Fructose Metabolism Disorder|Fructose Rich Diet|Metabolic Disease|Aerobic Exercise
Interventions: DIETARY_SUPPLEMENT: Fructose|DIETARY_SUPPLEMENT: Glucose|OTHER: Fructose and exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Marginal Integrity of Recent Bulk Fill Flowable Composite vs Glass Ionomer for Carious Cervical Restorations: RCCT
Status: COMPLETED
Conditions: Dental Caries Class v
Interventions: OTHER: restorative materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Tolerability of Creon Micro in Children Younger Than Four Years With Pancreatic Exocrine Insufficiency
Status: COMPLETED
Conditions: Pancreatic Exocrine Insufficiency
Interventions: DRUG: Pancreatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a GnRH Analog on Hepatic Steatosis
Status: NOT_YET_RECRUITING
Conditions: Metabolic Dysfunction-Associated Steatotic Liver Disease|Nonalcoholic Fatty Liver|Endometriosis
Interventions: DRUG: Goserelin Acetate 3.6 mg inj, implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Healthy Living Partnerships for Veterans With Migraine
Status: NOT_YET_RECRUITING
Conditions: Migraine|Migraine Disorders|Migraine With Aura|Migraine Without Aura
Interventions: BEHAVIORAL: Intensive Lifestyle Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of Anti-PD-1 Combinations of D-CIK Immunotherapy and Axitinib in Advanced Ranal Carcinoma
Status: UNKNOWN
Conditions: Renal Cancer Metastatic
Interventions: BIOLOGICAL: Combinations treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Predictive Value of Complement C3 in Patients With Advanced Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer|Complement Component Deficiency|Surgery
Interventions: PROCEDURE: gastrectomy plus D2 lymphadenectomy|DRUG: S-1+Oxaliplatin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Tolerability of Single and Multiple Doses of Neumifil
Status: COMPLETED
Conditions: Viral Respiratory Tract Infection
Interventions: DRUG: Neumifil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effıcıency of Sexual and Reproductıve Health Educatıon
Status: COMPLETED
Conditions: Reproductive Health|Sexual Health
Interventions: OTHER: Face-to-face Training Group|OTHER: DataMatrix supported Face-to-face training group|OTHER: Online training group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Establishing Evidence-based Indoor Temperature Thresholds to Protect Health
Status: COMPLETED
Conditions: Aging|Heat Stress|Physiological Stress
Interventions: OTHER: Simulated heatwave exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Adjunctive Laser for Periodontal Intrabony Defects
Status: UNKNOWN
Conditions: Periodontitis
Interventions: DEVICE: Er:YAG laser (Waterlase)|PROCEDURE: root surface dbridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pazopanib Hydrochloride in Treating Patients With Advanced Angiosarcoma
Status: COMPLETED
Conditions: Adult Angiosarcoma|Recurrent Adult Soft Tissue Sarcoma|Stage III Adult Soft Tissue Sarcoma|Stage IV Adult Soft Tissue Sarcoma
Interventions: DRUG: pazopanib hydrochloride|OTHER: laboratory biomarker analysis|PROCEDURE: positron emission tomography|PROCEDURE: computed tomography|RADIATION: fludeoxyglucose F 18
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Cilostazol on Coronary Artery Stenosis and Plaque Characteristics in Patients With T2DM
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Cilostazol|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Citrulline on the Clinical and Biochemical Evolution of Patients With Sepsis.
Status: UNKNOWN
Conditions: Sepsis
Interventions: DIETARY_SUPPLEMENT: Citrulline malate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of Multimodal Fusion Warning System and Non-invasive Techniques for Early Alzheimer's Detection.
Status: RECRUITING
Conditions: Alzheimer's Disease
Interventions: DEVICE: Transcranial ultrasound stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: N-Acetylcysteine for Preventing Renal Injury After Cardiac Surgery
Status: COMPLETED
Conditions: Heart Disease|Acute Renal Failure
Interventions: DRUG: N-acetylcysteine|OTHER: 5% dextrose solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Concomitant Use of Gardasil (V501) (Human Papillomavirus [Types 6, 11, 16, 18] Recombinant Vaccine) With Combined Diphtheria, Tetanus, Pertussis Vaccine and Meningococcal Conjugate Vaccine in Adolescents (V501-025)
Status: COMPLETED
Conditions: Neoplasms, Glandular and Epithelial|Diphtheria|Tetanus|Whooping Cough|Meningitis
Interventions: BIOLOGICAL: Comparator: Quadrivalent Human Papillomavirus (HPV) vaccine|BIOLOGICAL: Comparator: Menactra™ (Concomitant)|BIOLOGICAL: Comparator: Adacel™ (Concomitant)|BIOLOGICAL: Comparator: Menactra™ (Non-concomitant)|BIOLOGICAL: Comparator: Adacel™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Fascia Iliaca Compartment Blockade as Analgesia for Hip Fractures in the Acute Phase
Status: COMPLETED
Conditions: Hip Fracture
Interventions: PROCEDURE: Fascia Iliaca Compartment Blockade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients
Status: TERMINATED
Conditions: Septic Shock|Sepsis|Shock|Tachycardia|Arrhythmia
Interventions: DRUG: Phenylephrine|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sotagliflozin Versus Placebo in Participants With Type 2 Diabetes Mellitus on Background of Sulfonylurea Alone or With Metformin
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sotagliflozin (SAR439954)|DRUG: Placebo|DRUG: Metformin|DRUG: Sulfonylurea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Arsenic Trioxide Combined With Chemotherapy for the Treatment of p53-mutated Pediatric Cancer
Status: RECRUITING
Conditions: Pediatric Cancer|Li-Fraumeni Syndrome|p53 Mutations
Interventions: DRUG: Arsenic trioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Metastatic Breast Cancer With Fulvestrant Plus Palbociclib or Tamoxifen Plus Palbociclib
Status: UNKNOWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Fulvestrant|DRUG: Tamoxifen|DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Cognitive Psychophysiological Treatment for Tourette Syndrome and Tic Disorders
Status: COMPLETED
Conditions: Tic Disorder, Chronic Motor or Vocal|Tourette Syndrome in Children|Tourette Syndrome
Interventions: BEHAVIORAL: Cognitive behavioural treatment for tics|BEHAVIORAL: Cognitive psychophysiological
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF
Status: TERMINATED
Conditions: Acute on Chronic Hepatic Failure|Acute Liver Failure|Liver Cirrhosis|Acute Alcoholic Hepatitis
Interventions: DRUG: IDN-6556|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy of 90Yttrium-epratuzumab in Adults With CD22+ Relapsed/Refractory B-ALL
Status: WITHDRAWN
Conditions: CD22+ Relapsed/Refractory B-ALL
Interventions: DRUG: 90Y-epratuzumab tetraxetan|DRUG: chemotherapy/ immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Divozilimab in Patients With Systemic Scleroderma
Status: RECRUITING
Conditions: Systemic Scleroderma
Interventions: DRUG: Divozilimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optical Quality After Implantation of a Spherical or Aspherical Intraocular Lens in Hypermetropic Patients
Status: COMPLETED
Conditions: Cataract|Spherical Aberrations|Intraocular Lenses|Depth of Focus
Interventions: DEVICE: AMO Tecnis ZA9003|DEVICE: AMO Sensar AR40e
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Erlotinib With or Without SNDX-275 (Entinostat) in the Treatment of Patients With Advanced NSCLC
Status: COMPLETED
Conditions: Non-Small-Cell Lung Carcinoma|Carcinoma, Non-Small Cell Lung
Interventions: DRUG: Entinostat|DRUG: Placebo|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sex Differences in E-cig Perception: Study 1
Status: RECRUITING
Conditions: Nicotine Addiction|E-Cig Use|Cigarette Smoking|Sex Differences
Interventions: OTHER: E-liquid Flavor 1|OTHER: E-liquid Flavor 2|OTHER: E-liquid Flavor 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Combined Use of Radiofrequency-ablation and Balloon-septostomy in the Creation of a Stable Inter-atrial Communication
Status: RECRUITING
Conditions: Pulmonary Arterial Hypertension
Interventions: OTHER: Radiofrequency catheter ablation|OTHER: Balloon atrial septostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relationship to Dose of Triamcinolone Acetonide and Methylyprednisolone to Improvement in Subacromial Bursitis
Status: COMPLETED
Conditions: Subacromial Bursitis|Shoulder Pain
Interventions: DRUG: Methylprednisolone, 20 mg|DRUG: Methylprednisolone, 40 mg|DRUG: Triamcinolone, 20 mg|DRUG: Triamcinolone, 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Remote Monitoring of Patients With an Inflammatory Bowel Disease Under no or Maintenance Therapy
Status: NOT_YET_RECRUITING
Conditions: Crohn Disease|Colitis, Ulcerative|Inflammatory Bowel Diseases
Interventions: OTHER: Remote monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Lactose and Lipids
Status: UNKNOWN
Conditions: Cardiovascular Risk Factor|Lipaemia|Metabolic Disease
Interventions: DIETARY_SUPPLEMENT: Maltodextrin|DIETARY_SUPPLEMENT: Sucrose|DIETARY_SUPPLEMENT: Lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bilateral Transcranial Direct Current Stimulation and Ocular Occlusion for Adults With Amblyopia
Status: TERMINATED
Conditions: Amblyopia
Interventions: DEVICE: Bilateral transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determining the Minimal Effective Volume (MEAV95) for Interscalene Brachial Plexus Block for Surgical Anesthesia
Status: UNKNOWN
Conditions: Shoulder Pain
Interventions: PROCEDURE: Dose of of ropivacaine 0.75% used in block procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Major Depressive Disorder With BTRX-335140 (NMRA-335140) vs Placebo
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: BTRX-335140|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Leg Muscle Activity Measured Via Electromyography in Back Squat Variations
Status: COMPLETED
Conditions: Surface Electromyography|Muscular Fatigue
Interventions: OTHER: Traditional Back Squat|OTHER: Barefoot Back Squat|OTHER: Box Squat|OTHER: Traditional Back Squat with Chains
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: African American Families Fighting Parental Cancer Together
Status: RECRUITING
Conditions: Depressive Symptoms|Anxiety|Parental Stress
Interventions: BEHAVIORAL: Family-based attachment-focused intervention|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intermittent Preventive Treatment of Malaria in HIV-Seropositive Pregnant Women in Zambia
Status: COMPLETED
Conditions: Placental Malaria Infection|HIV Infections|Stillbirth|Prematurity|Neonatal Deaths
Interventions: DRUG: Sulfadoxine-pyrimethamine (Fansidar)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: RhD+ Blood Transfusion to Asian-type DEL Recipients
Status: COMPLETED
Conditions: Blood Transfusion|Rhesus Isoimmunisation Due to Anti-D|Blood Group Antigen Abnormality
Interventions: OTHER: Blood transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Mechanical Bowel Preparation Versus Enema for Candidates to Colorectal Resection for Adenocarcinoma
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: OTHER: mechanical bowel preparation|OTHER: enema
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Etanercept for Aneurysmal Subarachnoid Hemorrhage
Status: WITHDRAWN
Conditions: Subarachnoid Hemorrhage, Aneurysmal
Interventions: DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Where Pharmaco Magnetic Resonance Imaging (MRI) Effects of AZD6765 Will be Compared to Placebo in Depressive Male and Female Subjects
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: AZD6765|DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Developing an Integrated Psychotherapy With Cognitive-behavioral Therapy and Biofeedback Therapy for Somatic Symptom Disorder
Status: RECRUITING
Conditions: Somatic Symptom Disorder
Interventions: BEHAVIORAL: cognitive-behavioral therapy and biofeedback therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Personalized Information and Choices
Status: COMPLETED
Conditions: Feedback, Psychological|Underage Alcohol Use|Risk-Taking|Sex Behavior
Interventions: BEHAVIORAL: Reasoned-Based Intervention|BEHAVIORAL: Social-Based Intervention|BEHAVIORAL: Integrated Intervention|BEHAVIORAL: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Two Ratios of Propofol-ketamine Admixture for Rapid-sequence Induction Anesthesia for Emergency Laparotomy
Status: UNKNOWN
Conditions: Hypotension|Induction of Anesthesia
Interventions: DRUG: Ketofol equal ratio|DRUG: Ketofol 1:3 ratio
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Randomized Clinical Trial in Bellow-the-knee Angioplasty. Treatment of One or More Than One Artery.
Status: COMPLETED
Conditions: Atherosclerosis of Artery
Interventions: PROCEDURE: Angioplasty of distal arteries
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of ALV003 in Symptomatic in Celiac Disease Patients
Status: UNKNOWN
Conditions: Celiac Disease
Interventions: DRUG: ALV003|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prediction Models for Postoperative Reintubation in Patients With Acute Aortic Dissection
Status: COMPLETED
Conditions: Nomogram|Prediction Model|Type A Aortic Dissection|Postoperative Reintubation
Interventions: PROCEDURE: Type A aortic dissection surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 177Lu-PSMA, Niraparib/AA Plus Prednisone for Prostate Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastatic Prostate Cancer|Castration-resistant Prostate Cancer|Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: 177Lu-PSMA-617|DRUG: Niraparib abiraterone acetate|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Randomized Trial of Adjuvant XP Chemotherapy and XP/RT for Resected Gastric Adenocarcinoma
Status: COMPLETED
Conditions: Gastric Cancer|Surgery
Interventions: DRUG: Capecitabine, cisplatin, Radiotherapy (+/-)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Resection of Papillary Adenomas; a Novel Treatment Algorithm to Prevent Recurrence - a Pilot-study
Status: NOT_YET_RECRUITING
Conditions: Ampullary Adenoma
Interventions: PROCEDURE: Endoscopic papillectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Evaluation of Drotrecogin Alfa (Activated) in Patients With Blood Cancer, Severe Infection Related to Bone Marrow Transplantation
Status: COMPLETED
Conditions: Sepsis|Hematologic Neoplasms|Hematopoietic Stem Cell Transplantation|Infection
Interventions: DRUG: Drotrecogin Alfa (activated)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Whey Protein and Dietary Fibers on Risk Markers of the Metabolic Syndrome and Bone Health
Status: COMPLETED
Conditions: Abdominal Obesity|Metabolic Syndrome|Type 2 Diabetes|Cardiovascular Disease
Interventions: OTHER: Whey protein powder|OTHER: Maltodextrin powder|OTHER: High fiber bread|OTHER: Low fiber bread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Management of Pain Post Hepatectomy : Infiltration of Local Anesthetics Versus Continuous Spinal Analgesia .
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: intrathecal morphine|DRUG: Morphine PCA|DRUG: Ropivacaine infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GO PRP: Assessing the Efficacy of Intra Articular Injection of Platelets Rich Plasma for Gonarthrosis Treatment in Routine Care
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: autologous PRP.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Brain Stimulation in Huntington's Disease
Status: UNKNOWN
Conditions: Huntington Disease
Interventions: DEVICE: Active Transcranial pulsed current stimulation (tPCS)|DEVICE: Sham Transcranial pulsed current stimulation (tPCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Efficacy and Safety of OLE LIB003 in HoFH, HeFH, and High-risk CVD Patients Requiring Further LDL-C Reduction
Status: ENROLLING_BY_INVITATION
Conditions: Cardiovascular Disease With Mention of Arteriosclerosis|Elevated Cholesterol|Familial Hypercholesterolemia
Interventions: DRUG: lerodalcibep
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT