pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Overall Survival of Inoperable Gastric/GastroOesophageal Cancer Subjects on Treating With LMWH + Chemotherapy(CT) vs Standard CT
Status: COMPLETED
Conditions: Gastric Cancer|Gastroesophageal Cancer
Interventions: DRUG: Enoxaparin|DRUG: Standard Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Real-World Comparative Observational Study in Non-Valvular Atrial Fibrillation Patients Using Oral Anticoagulants
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Warfarin|DRUG: Apixaban|DRUG: Dabigatran|DRUG: Rivaroxaban
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Safety and Efficacy of Sublingual/Oral Immunotherapy for the Treatment of Milk Protein Allergy
Status: COMPLETED
Conditions: Milk Allergy
Interventions: DRUG: Milk Protein Extract Immunotherapy goal of 4mg/day|DRUG: Milk Protein Extract Immunotherapy goal of 7mg/day|DRUG: Milk Powder Immunotherapy goal dose 2000 mg/day|DRUG: Milk Powder Immunotherapy goal dose 1000mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lumateperone for the Improvement of Apathy in Patients With Psychotic Symptoms.
Status: RECRUITING
Conditions: Apathy|Schizophrenia|Schizophrenia; Psychosis
Interventions: DRUG: Lumateperone 42 mg|DRUG: Risperidone 2 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Silkworms (Bombyx Mori L.) Pupae Extracts on Musculoskeletal Biomarkers in Adults
Status: COMPLETED
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: silkworms (Bombyx mori L.) pupae extracts group|DIETARY_SUPPLEMENT: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Surufatinib Combined With Toripalimab and HAIC in the Treatment of Inoperable or Metastatic Intrahepatic Cholangiocarcinoma
Status: NOT_YET_RECRUITING
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DRUG: Surufatinib、Toripalimab、Gemcitabine、Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Controlled Study of ONO-1101 in Patients With Postoperative Tachyarrhythmias in Japan
Status: COMPLETED
Conditions: Postoperative Supraventricular Tachyarrythmia
Interventions: DRUG: ONO-1101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Can Hyperoxia be Prevented With Noninvasive Monitoring in On-pump Cardiac Surgery?
Status: COMPLETED
Conditions: Hyperoxia|Oxygen Reserve Index|Cardiac Surgery
Interventions: DEVICE: ORI group|OTHER: Conventional group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Combination Chemotherapy in Treating Patients With Ovarian Epithelial, Fallopian Tube, or Peritoneal Cancer
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: carboplatin|DRUG: gemcitabine hydrochloride|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Treatment With High Flow Nasal Cannulas on Respiratory Pattern and Work of Breathing Among Patients.
Status: UNKNOWN
Conditions: Respiratory Failure
Interventions: DEVICE: Airvo 2; Ficher and Paykel HealthCare|DEVICE: Oxygen delivery via conventional nasal mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: CEFtolozane-Tazobactam for the Empiric Anti-bacterial Treatment of Neutropenic Fever in Hematology Patients
Status: WITHDRAWN
Conditions: Neutropenia, Febrile|Hematologic Cancer
Interventions: DRUG: Ceftolozane-tazobactam IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab and Ipilimumab Plus Chemotherapy for Patients With Stage IV Lung Cancer With Brain Metastases
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer|Brain Metastases, Adult|Lung Cancer
Interventions: DRUG: Ipilimumab|DRUG: Nivolumab|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Paclitaxel|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ramelteon (ROZEREM) in the Treatment of Sleep Disturbances Associated With Parkinson's Disease
Status: TERMINATED
Conditions: Parkinson's Disease
Interventions: DRUG: ROZEREM|DRUG: Ramelteon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Alcohol Screening & Brief Lntervention in Juvenile Justice: Filling the Gap
Status: COMPLETED
Conditions: Evaluating NIAAA's Alcohol Screener|Evaluating a Brief Intervention
Interventions: BEHAVIORAL: Brief Intervention|BEHAVIORAL: Brief Intervention with Coaching|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation in Psychiatric Illnesses
Status: COMPLETED
Conditions: Obesity|Vitamin D Deficiency|Psychosis|Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Ergocalciferols
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study on Effect Size of Non-digestible Polysaccharides (NPS) on Immunity
Status: COMPLETED
Conditions: Immunosenescence
Interventions: DIETARY_SUPPLEMENT: NPS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: IL-39 & IL-35 Gingival Crevicular Fluid Levels in Diabetic Patients With Generalized Periodontitis
Status: COMPLETED
Conditions: Generalized Periodontal Disease, AVDC Stage 3
Interventions: PROCEDURE: Scaling & root planning
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Nifedipine in the Management of Preterm Labor
Status: UNKNOWN
Conditions: Preterm Labor|Preterm Birth|Preterm Labor Without Delivery|Preterm Labor With Preterm Delivery in Third Trimester|Calcium-Channel Blockers Toxicity|Side Effect of Drug
Interventions: DRUG: Nifedipine 10 mg
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: James EMBAR® Light Therapy in the Treatment of Burn Wounds of Intermediate Depth
Status: COMPLETED
Conditions: Burns
Interventions: PROCEDURE: Phototherapy with the Embar® light therapy or sham irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Functional Epiphora Management Via Different Dacryocystorhinostomy (DCR) Techniques
Status: COMPLETED
Conditions: Functional Epiphora (Tearing Without Any Anatomical Block)
Interventions: PROCEDURE: External Dacryocystorhinostomy|PROCEDURE: Endonasal Dacryocystorhinostomy|PROCEDURE: Transcanalicular Dacryocystorhinostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Symbicort® pMDI 2 x 160/4.5 μg Bid and Symbicort® pMDI 2 x 80/4.5 μg Bid With Formoterol Turbuhaler®, Budesonide pMDI, the Combination of Formoterol Turbuhaler® and Budesonide pMDI, and Placebo in COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Budesonide/formoterol pMDI|DRUG: Budesonide pMDI|DRUG: Formoterol Turbuhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of Lipid Emulsion on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol.
Status: COMPLETED
Conditions: Drug Overdose|Overdose of Beta-adrenergic Blocking Drug|Blood Pressure
Interventions: DRUG: metoprolol|DRUG: intravenous lipid emulsion|DRUG: Sodium chloride 0.9% solution - lipid emulsion dummy|DRUG: Sodium chloride 0.9% solution - metoprolol dummy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study of the Treatment of Chiari Malformation Combined With Type II Skull Base Depression
Status: RECRUITING
Conditions: Atlantoaxial Dislocation|Chiari Malformation|Basilar Invagination
Interventions: PROCEDURE: Atlas occipital decompression lateral joint release combined with occipital-neck fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interleukin-2 Therapy for HIV Infection - Supplemental Procedures
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome|HIV Infection
Interventions: DRUG: Interleukin-2/Zidovudine (AZT)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Aerosol Particle Concentrations Among Different Oxygen Devices for Spontaneous Breathing Patients With Tracheostomy
Status: COMPLETED
Conditions: Transmission, Patient-Professional
Interventions: DEVICE: high-flow high humidity oxygen device with tracheostomy adapter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of a New Intravenous Drug, Called S65487, in Patients With Acute Myeloid Leukemia, Non Hodgkin Lymphoma, Multiple Myeloma or Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Relapsed or Refractory Acute Myeloid Leukemia|Relapsed or Refractory Non-Hodgkin Lymphoma|Relapsed or Refractory Multiple Myeloma|Relapsed or Refractory Chronic Lymphocytic Leukemia
Interventions: DRUG: S65487- initial scheme|DRUG: S65487 - alternative scheme
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhibition of the Renin Angiotensin System With Losartan in Patients With Hypertrophic Cardiomyopathy
Status: COMPLETED
Conditions: Hypertrophic Cardiomyopathy
Interventions: DRUG: Losartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel Protein Bound Plus Cisplatin Plus Gemcitabine and Paricalcitol for Pancreatic Adenocarcinoma (NABPLAGEMD)
Status: COMPLETED
Conditions: Pancreatic Cancer|Pancreatic Ductal Adenocarcinoma|Pancreatic Adenocarcinoma|Pancreas Metastases|Adenocarcinoma
Interventions: DRUG: Paricalcitol (Zemplar)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TDCS as Augmentation Therapy to Cognitive Training in Mild Dementia
Status: NOT_YET_RECRUITING
Conditions: Major Neurocognitive Disorder
Interventions: DEVICE: transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Wireless Sensors in Neonatal Intensive Care
Status: RECRUITING
Conditions: Preterm Birth|Apnea of Newborn
Interventions: DEVICE: ANNE™ Monitoring System (2 sensors) - version B|DEVICE: ANNE™ Monitoring System (2 sensors) - version C|DEVICE: ANNE™ Monitoring System (2 sensors) - version C
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation the Impact of Self-Stigma Reduction Program on Psychosocial Outcomes Among People Diagnosed With Schizophrenia
Status: COMPLETED
Conditions: Stigmatization
Interventions: BEHAVIORAL: Stigma reduction program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Treatment of Patients With Everolimus and Imatinib Mesylate Who Have Progressive Gastro Intestinal Stromal Tumors (GIST) and Are Resistant to Imatinib Mesylate
Status: COMPLETED
Conditions: Progressive Gastrointestinal Stromal Tumor
Interventions: DRUG: Imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retropubic vs. Transobturator Tension-free Vaginal Tape
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: Transobturator Tension-free vaginal tape (TVT-O)|DEVICE: Retropubic Tension-free vaginal tape (TVT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-008, BELLWAVE-008)
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Leukemia
Interventions: DRUG: Nemtabrutinib|DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Bendamustine|BIOLOGICAL: Rituximab|BIOLOGICAL: Truxima|BIOLOGICAL: Ruxience|BIOLOGICAL: Riabni
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Targeted Training on the Postural Control and Gross Motor Function in Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: Regular physiotherapy|OTHER: Targeted Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: New Fabric Attenuation Device in Endovascular Interventional Radiology II (PREFER II)
Status: COMPLETED
Conditions: Occupational Exposure to Radiation
Interventions: DEVICE: XPF thyroid collar|DEVICE: Standard 0.5mm lead equivalent thyroid collar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: chemotherapy|DRUG: cisplatin|RADIATION: low-LET cobalt-60 gamma ray therapy|RADIATION: low-LET electron therapy|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Optical Coherence Tomography Guided Percutaneous Coronary Intervention for Drug-eluting In-stent Restenosis
Status: UNKNOWN
Conditions: CHD - Coronary Heart Disease|Percutaneous Coronary Intervention|In-stent Restenosis
Interventions: PROCEDURE: Percutaneous Coronary Intervention under OCT|PROCEDURE: Percutaneous Coronary Intervention under Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of an Intranasal Proteosome Influenza Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Placebo Protesomal Vaccine|BIOLOGICAL: Experimental: Protesomal Vaccine 1 x 30 µg|BIOLOGICAL: Experimental: Protesomal Vaccine 2 x 30 µg|BIOLOGICAL: Experimental: Protesomal Vaccine 2 x 15 µg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Hard and Soft Tissue Changes Following Vestibular Socket Preservation Versus Ice Cream Cone Technique for Management of Defective Fresh Extraction Sockets in the Esthetic Zone: A Randomized Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Alveolar Ridge Preservation
Interventions: PROCEDURE: Intervention group Vestibular Socket Preservation|PROCEDURE: Control Group ice cream cone technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Vitamin D Supplementation on Patients With Type 2 Diabetes and Vitamin D Deficiency
Status: COMPLETED
Conditions: Diabetes Mellitus|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Rechargeable Spinal Cord Stimulators for the Treatment of Neuropathic Pain
Status: COMPLETED
Conditions: Neuropathic Pain
Interventions: OTHER: F-SUS Questionnaire|OTHER: Interview (only for dissatisfied patients)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase 2 Study of Nimotuzumab in Pediatric Recurrent Diffuse Intrinsic Pontine Glioma
Status: COMPLETED
Conditions: Recurrent Diffuse Pontine Gliomas
Interventions: BIOLOGICAL: nimotuzumab (anti EGFR humanized monoclonal antibody)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center Phase I Study of Intravenous Deforolimus (AP23573, MK-8669) Administered QDX5 Every Other Week in Pediatric Patients With Advanced Solid Tumors (8669-028)(COMPLETED)
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: ridaforolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Pathways Involved in Cardiac Remodeling in Patients With Chronic Heart Failure With Preserved Ejection Fraction by New Omics Technologies
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Heart Disease
Interventions: GENETIC: study of molecular and protein pathways
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cerebral Oxygen Saturation Monitoring In Cardiac Surgery (COSMICS)
Status: RECRUITING
Conditions: Cardiac Disease|Cognitive Dysfunction
Interventions: DEVICE: Cerebral oximetry monitor (The INVOS® Cerebral/Somatic Oximeter) and protocol-based interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cytarabine With or Without VNP40101M in Treating Patients With Relapsed Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: cytarabine|DRUG: laromustine|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Fluid Therapy Optimization in Spinal Surgery
Status: COMPLETED
Conditions: Hypovolemia|Hypervolemia
Interventions: PROCEDURE: Standard care group|PROCEDURE: Noninvasive monitoring group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Background Noise on Sleep Quality
Status: COMPLETED
Conditions: Sleep Onset Insomnia
Interventions: DEVICE: NIghtingale (R) device for filtered white noise (Cambridge Sound Management, Waltham, MA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Randomized, Double-Blind Study of the Efficacy of Omalizumab (Xolair) in Atopic Asthmatics With Good Lung Capacity Who Remain Difficult to Treat (EXACT)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: omalizumab (Xolair)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact on Carriage, Acute Otitis Media, Immuno & Safety of GSK Biologicals' Pneumococcal Conjugate Vaccine 1024850A
Status: COMPLETED
Conditions: Infections, Streptococcal|Streptococcus Pneumoniae
Interventions: BIOLOGICAL: Pneumococcal conjugate vaccine Synflorix (GSK1024850A)|BIOLOGICAL: GSK Biologicals' Engerix TM vaccine (Hepatitis B vaccine)|BIOLOGICAL: GSK Biologicals' Havrix TM vaccine (Hepatitis A vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Rosuvastatin on Left Ventricular Remodeling
Status: COMPLETED
Conditions: Dilated Cardiomyopathy
Interventions: DRUG: Rosuvastatin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Study to Assess the Efficacy of the Avène Hydrotherapy
Status: COMPLETED
Conditions: Chronic Pruritus Due to Plaque Psoriasis
Interventions: OTHER: Hydrotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Amlodipine Use in the Prevention and Treatment of Iron Overload in Patients With Thalassemia Major
Status: COMPLETED
Conditions: Thalassemia Major
Interventions: DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Citrus Bioflavonoids/Vitamin E in Conjunction With Fish Oil Supplementation
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DIETARY_SUPPLEMENT: FishOil|DIETARY_SUPPLEMENT: CBE75|DIETARY_SUPPLEMENT: CBE150|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Preliminary Drug Drug Interaction Study With TA-8995
Status: COMPLETED
Conditions: Pharmacokinetic Interactions
Interventions: DRUG: TA-8995|DRUG: Midazolam|DRUG: Digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Tramadol Hydrochnoride as Adjuvant to Local Anesthetic in Ultrasound Guided Erector Spinea Plane Block in Management of Chronic Chest Wall Cancer Pain
Status: UNKNOWN
Conditions: Chronic Pain|Erector Spinea Plane Block
Interventions: PROCEDURE: Erector spinea plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone Intravitreal Implant for Treatment of Macular Edema After Plaque Radiotherapy of Uveal Melanoma
Status: TERMINATED
Conditions: Macular Edema|Cystoid Macular Edema|Uveal Melanoma|Radiation Maculopathy|Radiation Retinopathy
Interventions: DRUG: Ozurdex|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Two-part Single- and Repeat-dose Study of CSJ137 in Anemic Chronic Hemodialysis Patients
Status: COMPLETED
Conditions: Anemia, Iron-Deficiency
Interventions: BIOLOGICAL: CSJ137|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS)
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: OTHER: Progressive exercise|DEVICE: Neuromuscular electrical stimulation delivered using the electrical therapy device EMPI 300 PV|OTHER: Modified paleolithic diet|DIETARY_SUPPLEMENT: Omega 3 fatty acids|DIETARY_SUPPLEMENT: Full Spectrum vitamin|DIETARY_SUPPLEMENT: Essential - hydroxytyrosol|DIETARY_SUPPLEMENT: Maltodextrin fiber supplement|DIETARY_SUPPLEMENT: Mineral boost (magnesium)|DIETARY_SUPPLEMENT: Niacinamide|DIETARY_SUPPLEMENT: Methyl B12|DIETARY_SUPPLEMENT: Taurine|DIETARY_SUPPLEMENT: creatine|DIETARY_SUPPLEMENT: thiamine|DIETARY_SUPPLEMENT: riboflavin|DIETARY_SUPPLEMENT: N acetylcysteine|DIETARY_SUPPLEMENT: alpha lipoic acid|DIETARY_SUPPLEMENT: L acetyl carnitine|DIETARY_SUPPLEMENT: methyl folate|DIETARY_SUPPLEMENT: coenzyme Q|BEHAVIORAL: meditation|BEHAVIORAL: self massage|BEHAVIORAL: learning|DIETARY_SUPPLEMENT: Coconut oil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Longitudinal HPV Pap in CIN and VAIN
Status: RECRUITING
Conditions: Cervical Intraepithelial Neoplasia|Hysterectomy|Human Papillomavirus|Vaginal Intraepithelial Neoplasia
Interventions: OTHER: HPV test and Pap Smear
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Berlim 25/20 Association in the Treatment of Type II Diabetes Mellitus and Dyslipidemia.
Status: RECRUITING
Conditions: Dyslipidemia Associated With Type II Diabetes Mellitus
Interventions: DRUG: BERLIM 25/20 ASSOCIATION|OTHER: EMPAGLIFLOZIN PLACEBO|OTHER: ROSUVASTATIN CALCIUM PLACEBO|DRUG: EMPAGLIFLOZIN|DRUG: ROSUVASTATIN CALCIUM|OTHER: BERLIM 25/20 ASSOCIATION PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetic of Multiple-ascending Doses of LPM3770164 in Healthy Subjects
Status: RECRUITING
Conditions: Tardive Dyskinesia|Huntington Disease
Interventions: DRUG: LPM3770164 sustained release tablet|DRUG: LPM3770164 sustained release tablet simulant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Naptumomab Estafenatox in Combination With Durvalumab in Subjects With Selected Advanced or Metastatic Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: ER+ Breast Cancer|Ovarian Cancer|Cervical Squamous Cell Carcinoma|Pancreatic Adenocarcinoma|Endometrial Cancer|Renal Cell Carcinoma|Urothelial Cancer|Head and Neck Squamous Cell Carcinoma|Mesothelioma|Melanoma|Hepatocellular Carcinoma|Prostate Cancer|NSCLC|HER2-negative Breast Cancer|Triple Negative Breast Cancer|Bladder Cancer|Colorectal Cancer Metastatic|GastroEsophageal Cancer|NSCL2 Gene Mutation
Interventions: COMBINATION_PRODUCT: Obinutuzumab pretreatment (Gazyva®) Naptumomab estafenatox (ABR-217620; NAP) and durvalumab (IMFINZI; MEDI4736)|COMBINATION_PRODUCT: Naptumomab estafenatox (ABR-217620; NAP) and durvalumab (IMFINZI; MEDI4736)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Preference Study of Two Pneumatic Compression Devices for Patients With Lower Limb Lymphedema
Status: COMPLETED
Conditions: Lymphedema of Leg|Lymphedema|Lymphedema, Secondary|Lymphedema Primary|Lymphedema, Lower Limb
Interventions: DEVICE: Aria Health Aria Free|DEVICE: A Traditional PCD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Practices and Prognostic Factors of Percutaneous Coronary Interventions (PCI) of Calcified Complex Lesions Using Rotational Atherectomy Device.
Status: COMPLETED
Conditions: Angioplasty
Interventions: DEVICE: rotational atherectomy device
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of AMP Human Sodium Bicarbonate Lotion on Dehydrated Heat Stress
Status: COMPLETED
Conditions: Fluid Retention|Sodium Retention|Heat Stress|Dehydration (Physiology)|Renal Injury|Electrolyte and Fluid Balance Conditions
Interventions: OTHER: PR Lotion - AMP Human Performance|OTHER: Placebo Lotion|OTHER: AminoVital - Rapid Recovery|OTHER: Placebo Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Thoracoabdominal Asynchrony and Respiratory Distress
Status: UNKNOWN
Conditions: Respiratory Insufficiency
Interventions: DIAGNOSTIC_TEST: Objectively monitoring thoracoabdominal asynchrony
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Y402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population
Status: UNKNOWN
Conditions: Age-Related Macular Degeneration
Interventions: PROCEDURE: drawing blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy, Tolerability and Acceptability of Biktarvy by TPLWH
Status: TERMINATED
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: BIKTARVY 50Mg-200Mg-25Mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of the Addition of SNDX-275 (Entinostat) to Continued Aromatase Inhibitor (AI) Therapy in Postmenopausal Women With ER+ Breast Cancer Whose Disease is Progressing
Status: COMPLETED
Conditions: ER+ Breast Cancer
Interventions: DRUG: Entinostat|DRUG: Aromatase Inhibitor (AI) Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genotypic Resistance Guided Versus Susceptibility Testing Guided Therapy for the First-line Eradication of H. Pylori
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: GGT|DRUG: SGT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Mosquito Net Mesh for Ventral Hernia Repair
Status: UNKNOWN
Conditions: Hernia, Ventral|Ventral Incisional Hernia
Interventions: PROCEDURE: Rives technique|PROCEDURE: Drainage|DRUG: Prophylactic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Ferric Carboxymaltose With Placebo in Patients With Acute Heart Failure and Iron Deficiency
Status: COMPLETED
Conditions: Iron Deficiency|Heart Failure
Interventions: DRUG: ferric carboxymaltose|OTHER: Normal saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Discharge Educational Strategies for Reduction of Vascular Events
Status: COMPLETED
Conditions: Intracerebral Infarcts|Ischemic Stroke|Hemorrhagic Strokes|TIA's
Interventions: BEHAVIORAL: DESERVE education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: MABp1 IN HIDRADENITIS SUPPURATIVA REFRACTORY TO ADALIMUMAB
Status: COMPLETED
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: MABp1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Non-Specific Immunological Effects of Providing Oral Polio Vaccine to Seniors in Guinea-Bissau
Status: ENROLLING_BY_INVITATION
Conditions: Vaccine Reaction
Interventions: BIOLOGICAL: Oral polio vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Supporting Trans Identities and Occupational Justice Through Narrative Informed Theatre: Supporting Trans Identities and Occupational Justice Through Narrative Informed Theatre
Status: COMPLETED
Conditions: Transgenderism|Stigma, Social
Interventions: OTHER: IDEAS (Identity Evolution and Sharing) Performance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety Evaluation of 3K3A-APC in Ischemic Stroke
Status: NOT_YET_RECRUITING
Conditions: Ischemic Stroke
Interventions: BIOLOGICAL: 3K3A-APC|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Field Magnetic Resonance Spectroscopy Imaging for Follow Up of Prostate Cancer Post Brachytherapy Implantation
Status: COMPLETED
Conditions: Prostatic Neoplasm
Interventions: PROCEDURE: Magnetic Resonance Spectroscopy Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Interscalene Brachial Plexus Block and Intra-articular Injection of Ropivacaine for Post-operative Analgesia in Arthroscopic Shoulder Stabilization Surgery
Status: UNKNOWN
Conditions: Postoperative Analgesia
Interventions: PROCEDURE: Interscalene brachial plexus block|PROCEDURE: Intra-articular Ropivacaine injection|DEVICE: Ultrasound guided technique|DRUG: Ropivacaine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Rollover Study for Subjects Who Completed Participation in IMSA101-101 Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor, Adult
Interventions: DRUG: IMSA101|DRUG: Immune Checkpoint Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Economic Evaluation of Systemic Treatments for Moderate-to-severe Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Methotrexate|DRUG: Cyclosporins|DRUG: fumaric acid|DRUG: Acitretin|DRUG: Infliximab|DRUG: etanercept|DRUG: Adalimumab|DRUG: Ustekinumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigating the Preventative Ability of Massage Therapy on Paclitaxel Induced Peripheral Neuropathy
Status: TERMINATED
Conditions: Breast Cancer|Neuropathy|Neuropathy;Peripheral
Interventions: OTHER: Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diagnostic Accuracy of Imaging Findings in TBM/Spinal Tubercular Arachnoiditis and Correlation With Outcomes
Status: RECRUITING
Conditions: Tuberculous Meningitis|Tuberculous Arachnoiditis
Interventions: DIAGNOSTIC_TEST: MRI Brain and spine|DIAGNOSTIC_TEST: Reference standard diagnostic criteria
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of IBI303 in Adult Patients With Active Ankylosing Spondylitis
Status: COMPLETED
Conditions: AS
Interventions: DRUG: IBI303|DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Antidepressant and Behavioural Intervention
Status: COMPLETED
Conditions: Low Mood|Depression|Anxiety
Interventions: DRUG: Citalopram|BEHAVIORAL: Behavioural Activation|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cold Atmospheric Plasma Device for Pediatric Molluscum and Verruca
Status: COMPLETED
Conditions: Verruca Vulgaris|Molluscum Contagiosum Skin Infection
Interventions: DEVICE: Floating electrode-dielectric barrier device (FE-DBD) cold atmospheric plasma (CAP)|DEVICE: Cryotherapy|DRUG: Canthardin Collodion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Perioperative Care Based on Patient Reported Outcomes Measures
Status: RECRUITING
Conditions: Surgery|Perioperative Medicine
Interventions: BEHAVIORAL: Experimental group: OPTIMISTIC follow-up|OTHER: Control group: Usual conventional follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Role of Aromatase Inhibitor to Enhance Ovulation in Poor Responder During Induction With Short Antagonist Protocol in Cases of ICSI
Status: COMPLETED
Conditions: Infertility Indicated for ICSI
Interventions: DRUG: induction with aromataze inhibitor|DRUG: HMG|DRUG: GnRh a|DRUG: HCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vorinostat (MK-0683, SAHA [Suberoylanilide Hydroxamic Acid]) + Lenalidomide + Dexamethasone in Multiple Myeloma (MM) (MK-0683-074)
Status: COMPLETED
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: DRUG: Vorinostat|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Broccoli Sprout Extract on Keratinocyte Differentiation in Normal Skin
Status: COMPLETED
Conditions: Epidermolysis Bullosa Simplex|Pachyonychia Congenita
Interventions: DRUG: Jojoba oil with broccoli sprout extract|DRUG: Jojoba oil (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Evaluation of the Safety and Efficacy of EXPAREL When Administered Into the TAP in Subjects Undergoing Cesarean Section
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: Intrathecal morphine injection|DRUG: EXPAREL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smoking Treatment and Exercise Program for Underserved Populations (STEP UP)
Status: COMPLETED
Conditions: Smoking
Interventions: BEHAVIORAL: Cognitive Behavioral Counseling|BEHAVIORAL: Mobile Contingency Management|DRUG: Bupropion|DRUG: Transdermal nicotine patch|DRUG: Nicotine polacrilex|DRUG: Nicotine lozenge
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Portal and Graft Purge in Living Donor Liver Transplantation
Status: UNKNOWN
Conditions: Hypotension|Ischemia Reperfusion Injury
Interventions: OTHER: bolus purge|OTHER: Intermittent purge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sirolimus and Vaccine Therapy in Treating Patients With Stage II-IV Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity Cancer
Status: COMPLETED
Conditions: Recurrent Fallopian Tube Cancer|Recurrent Ovarian Epithelial Cancer|Recurrent Primary Peritoneal Cavity Cancer|Stage IIA Fallopian Tube Cancer|Stage IIA Ovarian Epithelial Cancer|Stage IIA Primary Peritoneal Cavity Cancer|Stage IIB Fallopian Tube Cancer|Stage IIB Ovarian Epithelial Cancer|Stage IIB Primary Peritoneal Cavity Cancer|Stage IIC Fallopian Tube Cancer|Stage IIC Ovarian Epithelial Cancer|Stage IIC Primary Peritoneal Cavity Cancer|Stage IIIA Fallopian Tube Cancer|Stage IIIA Ovarian Epithelial Cancer|Stage IIIA Primary Peritoneal Cavity Cancer|Stage IIIB Fallopian Tube Cancer|Stage IIIB Ovarian Epithelial Cancer|Stage IIIB Primary Peritoneal Cavity Cancer|Stage IIIC Fallopian Tube Cancer|Stage IIIC Ovarian Epithelial Cancer|Stage IIIC Primary Peritoneal Cavity Cancer|Stage IV Fallopian Tube Cancer|Stage IV Ovarian Epithelial Cancer|Stage IV Primary Peritoneal Cavity Cancer
Interventions: BIOLOGICAL: ALVAC(2)-NY-ESO-1 (M)/TRICOM vaccine|DRUG: sirolimus|OTHER: laboratory biomarker analysis|BIOLOGICAL: sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Venus P-valve to Treat RVOT Stenosis With Pulmonary Regurgitation
Status: UNKNOWN
Conditions: Right Ventricular Outflow Tract Stenosis
Interventions: DEVICE: Venus P-valve transcatheter implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging SARS-CoV-2 Involvement of Leptomeninges, Olfactory and Limbic Areas
Status: COMPLETED
Conditions: Estimate, With the Contribution of Optimized MRI, the Prevalence of Neurological and Neurovascular Manifestations on Imaging in the Event of SARS-CoV-2
Interventions: OTHER: MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Non-invasive Brain Stimulation of the Prefrontal Cortex in Substance Use Disorders
Status: RECRUITING
Conditions: Alcohol Use Disorder (AUD)
Interventions: DEVICE: High Definition transcranial direct current stimulation (HD-tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vestibular Pain Interactions
Status: COMPLETED
Conditions: Healthy
Interventions: PROCEDURE: Quantitative sensory testing|PROCEDURE: CHEPS|PROCEDURE: 3D Turntable|PROCEDURE: Vection stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dose-Ranging Study to Assess the Safety and Efficacy of Melatonin in Outpatients Infected With COVID-19
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: Melatonin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study Of The Caya® Diaphragm Used With ContraGel®
Status: COMPLETED
Conditions: Contraception
Interventions: DEVICE: ContraGel|DEVICE: HEC Universal Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 18F-PSMA PET/CT for Visualization of Glioblastoma Multiforme
Status: UNKNOWN
Conditions: Glioblastoma Multiforme
Interventions: OTHER: 18F-PSMA-1007 PET tracer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison Between Propofol and Inhalational Anaesthetic Agents on Cardiovascular Outcomes Following Cardiac Surgery
Status: UNKNOWN
Conditions: Coronary Heart Disease|Cardiovascular Diseases
Interventions: DRUG: Isoflurane, Sevoflurane or Desflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Adenoviral Vector Monotherapy or Combination With Chemotherapy in Subjects With Recurrent/Metastatic Breast Cancer.
Status: COMPLETED
Conditions: Breast Cancer Nos Metastatic Recurrent
Interventions: GENETIC: Ad-RTS-hIL-12 and Veledimex|DRUG: Palifosfamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CCX140-B in Subjects With FSGS
Status: COMPLETED
Conditions: FSGS|Focal Segmental Glomerulosclerosis|Glomerulosclerosis
Interventions: OTHER: Placebo|DRUG: CCX140-B|DRUG: CCX140-B|DRUG: CCX140-B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Core Stabilization Exercise Program in Obese Subjects Awaiting Bariatric Surgery
Status: COMPLETED
Conditions: Obese|Exercise|Bariatric Surgery Candidate
Interventions: OTHER: Core-Stabilization Exercise|OTHER: Counseling of physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cabozantinib Plus Pembrolizumab for Recurrent, Persistent and/or Metastatic Cervical Cancer
Status: TERMINATED
Conditions: Cervical Cancer|Recurrent Cervical Cancer|Metastatic Cervical Cancer|Persistent Cervical Cancer
Interventions: DRUG: Cabozantinib 40 MG oral once a day|DRUG: Pembrolizumab 200 mg IV every 3 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Clamping Method the Indwelling Urinary Catheters
Status: UNKNOWN
Conditions: Bladder Training by Clamping Before Removal
Interventions: OTHER: clamped catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Open Label Study for the Functional Characterization of Drug Metabolism and Transport
Status: COMPLETED
Conditions: Genotype-related Drug Metabolism
Interventions: DRUG: Codeine|DRUG: Midazolam|DRUG: pravastatin|DRUG: Talinolol|DRUG: torsemide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect in Wedge Resection and IVb/V Resection of the Liver for Gallbladder Cancer
Status: RECRUITING
Conditions: Gallbladder Cancer
Interventions: PROCEDURE: wedge resection|PROCEDURE: bisegmentectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tebipenem on Normal Human Intestinal Microbiota
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: TBPM-PI-HBr|DRUG: amoxicillin-clavulanate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT