pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Mitochondrial Membrane Protein Neurodegeneration (MPAN)
Status: COMPLETED
Conditions: MPAN
Interventions: OTHER: Passive Stretching|OTHER: Mobilization|OTHER: Muscle strengthening|OTHER: Balance and Coordination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Muscle Training (IMT) in Adult People With Pompe Disease
Status: RECRUITING
Conditions: Glycogen Storage Disease Type II|Pompe Disease (Late-onset)
Interventions: DEVICE: Inspiratory Muscle Training (IMT)|DEVICE: Inspiratory Muscle Training (IMT) + Air Stacking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Human Erythropoietin Improve Neurodevelopmental Outcomes in Extremely Preterm Infants
Status: UNKNOWN
Conditions: Developmental Disabilities
Interventions: DRUG: Recombinant human erythropoietin|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Two Vaginal Products Versus Placebo in Patients With Vaginal Discomfort
Status: COMPLETED
Conditions: Vulvodynia
Interventions: DRUG: Lidocaine/Diphenhydramine|DRUG: lidocaine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Effectiveness of AdvaCoat Sinus Gel
Status: COMPLETED
Conditions: Ethmoid Sinusitis|Rhinosinusitis
Interventions: DEVICE: AdvaCoat sinus gel|DEVICE: Merogel Injectable
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Attention Distractor on the Quality of Chest Compression
Status: COMPLETED
Conditions: Cardiopulmonary Resuscitation, Simulation Training
Interventions: OTHER: paced auditory serial addition test (PASAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Detemir Versus NPH for Type 2 Diabetes Mellitus in Pregnancy
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Neutral Protamine Hagedorn (NPH)|DRUG: Detemir insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sitagliptin and the Risk for Hypoglycaemia in Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Pharmacological Action
Interventions: DRUG: Sitagliptin 100 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of SGN-CD70A in Cancer Patients
Status: COMPLETED
Conditions: Renal Cell Carcinoma|Mantle-Cell Lymphoma|Diffuse, Large B-Cell, Lymphoma|Follicular Lymphoma, Grade 3
Interventions: DRUG: SGN-CD70A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab and Pertuzumab or Bevacizumab With Combination Chemotherapy in Treating Patients With Stage II-III Breast Cancer
Status: COMPLETED
Conditions: Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|BIOLOGICAL: Pertuzumab|DRUG: docetaxel|DRUG: carboplatin|DRUG: doxorubicin|DRUG: cyclophosphamide|DRUG: paclitaxel|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Plantar Flexion Training in People With Chronic Stroke
Status: COMPLETED
Conditions: Stroke|Hemiplegic Gait
Interventions: OTHER: Skateboard exercise at an incline angle of 0 degrees and 50% body weight|OTHER: Skateboard exercise at an incline angle of 5 degrees and 50% body weight|OTHER: Skateboard exercise at an incline angle determined to be optimal in phase 1 (either 0 or 5 degrees) and 75% body weight|OTHER: Skateboard exercise at an incline angle determined to be optimal in phase 1 (either 0 or 5 degrees) and 90% body weight|OTHER: Control 4-week exercise intervention|OTHER: Experimental 4-week exercise intervention|OTHER: Over-ground multi-directional gait training|OTHER: Home exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Relative Bioavailability of Bosutinib Capsules Under Fed Condition and Estimation of Food Effect on Orally Administered Bosutinib Capsule
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Bosutinib capsule|DRUG: Bosutinib capsule|DRUG: Bosutinib|DRUG: Bosutinib capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Doxorubicin and Bevacizumab in Treating Patients With Locally Recurrent or Metastatic Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Sarcoma
Interventions: BIOLOGICAL: bevacizumab|DRUG: doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cabazitaxel Versus the Switch to Alternative AR Targeted Therapy Enzalutamide or Abiraterone in Metastatic Castration-Resistant Prostate Cancer (mCRPC) Primary Resistant Patients to Abiraterone or Enzalutamide
Status: TERMINATED
Conditions: Prostate Cancer Metastatic
Interventions: DRUG: Cabazitaxel XRP6258|DRUG: Ezalutamide|DRUG: Abiraterone acetate|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia
Status: RECRUITING
Conditions: Dystonia|Drug Induced Dystonia|Parkinson Disease|Essential Tremor|Dyskinesias|Myoclonus|Tic Disorders|Torticollis|Ulnar Nerve Entrapment|Temporomandibular Joint Disorders|Dysphonia
Interventions: DIAGNOSTIC_TEST: DystoniaNet-based diagnosis of isolated dystonia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of MRX2843 in Subjects With Relapsed/Refractory Acute Myeloid Leukemia
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia Leukemia
Interventions: DRUG: MRX2843
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Initial Experience With Storz C-MAC Video Intubation System
Status: COMPLETED
Conditions: Intubation; Difficult
Interventions: DEVICE: C-MAC direct laryngoscopy|DEVICE: C-MAC Indirect laryngoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Endosonography For Right Side Acute Intestinal Mal-Symptoms (EFRAIM- Study)
Status: UNKNOWN
Conditions: Abdominal Pain
Interventions: PROCEDURE: EGD|PROCEDURE: EUS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: UED-A Videolaryngoscope vs. Glidescope Titanium for Elective Tracheal Intubation
Status: COMPLETED
Conditions: Intubation; Difficult or Failed
Interventions: DEVICE: UED-A Videolaryngoscopy|DEVICE: Glidescope Videolaryngoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Full Dose Enteric-coated Mycophenolate Sodium, in Addition to Cyclosporine for Microemulsion Reduced Dose, in Maintenance Renal Transplant Recipients
Status: TERMINATED
Conditions: Kidney Transplantation
Interventions: DRUG: Enteric coated mycophenolate sodium (Myfortic®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 1 Study to Evaluate Paclitaxel Conjugated CXC Receptor 4 Antagonist (MB1707) in Patients With Advanced Cancer
Status: WITHDRAWN
Conditions: Advanced Solid Tumor|Breast Cancer|Non Small Cell Lung Cancer|Ovary Cancer|Pancreatic Neoplasms
Interventions: DRUG: MB1707
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ablation STrategies for Repeat PrOcedures in Patients With Atrial Fibrillation Recurrences
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Catheter ablation using irrigated radiofrequency current ablation or cryothermal energy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MagicTouch™Sirolimus-Coated Balloon for Treatment of Coronary Artery Lesions in Small Vessels
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease|Native Coronary Artery Stenosis|Cardiovascular Diseases
Interventions: DEVICE: Sirolimus Drug Coated Balloon|DEVICE: Drug eluting stents (DES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fissure Sealant Retention Trial
Status: UNKNOWN
Conditions: Fissure Sealant Loss
Interventions: OTHER: Total etch bonding agent (5th generation)|OTHER: Self etch (7th generation ) bonding agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Diode Laser Photo Activation for Pocket Reduction Decontamination A Clinical Study
Status: COMPLETED
Conditions: Pocket, Periodontal|Periodontal Inflammation|Periodontal Attachment Loss|Periodontitis
Interventions: COMBINATION_PRODUCT: Diode laser and 3% hydrogen peroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Multi-center Trial of Goal-directed Fluid Management Based on Pulse Pressure Variation Monitoring
Status: COMPLETED
Conditions: Goal-directed Fluid Therapy|Hemodynamics Instability|High-risk Surgery|Pulse-pressure Variation|Postoperative Complications
Interventions: OTHER: Pulse pressure variation monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the QUadratus Lumborum Bloc in Total Hip ARthroplasty: Efficacy and Safety
Status: COMPLETED
Conditions: Postoperative Pain|Total Hip Replacement
Interventions: PROCEDURE: posterior Quadratus Lumborum Block (QLB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Subcutaneously Injected PD-L1 Antibody ASC22 in Chronic Hepatitis B Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Hepatitis b
Interventions: DRUG: ASC22|DRUG: sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of Metformin in the Prevention of HG in HR[+]/HER2[-] PIK3CA-mut Advanced BC Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Alpelisib|DRUG: Metformin|DRUG: Fulvestrant|DRUG: Letrozole|DRUG: Exemestane|DRUG: Vildagliptin|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for Obesity on Serum Metabolic Parameters
Status: COMPLETED
Conditions: Obesity
Interventions: DEVICE: Real acupuncture|DEVICE: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cholecystectomy First vs Sequential Common Bile Duct Imaging + Cholecystectomy
Status: COMPLETED
Conditions: Cholelithiasis|Cholecystitis
Interventions: PROCEDURE: Emergency cholecystectomy first|PROCEDURE: Sequential common bile duct imaging/cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Efficacy and Safety of Bone Marrow Derived Stem Cells in Patients With Critical Limb Ischemia
Status: COMPLETED
Conditions: Critical Limb Ischemia
Interventions: BIOLOGICAL: ASCT01 (Autologous Stem Cell Transplantation)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Trial of Oral Thalidomide in Advanced Hepatocellular Carcinoma With Poor Liver Reserve
Status: TERMINATED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Thalidomide(Thado)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Self-monitoring and Treatment of Blood Pressure Following Stroke or Transient Ischaemic Attack
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Self BP measurement|OTHER: Standard Care|OTHER: Standard BP management|OTHER: Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MDX-1100 in Subjects With Active Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: BIOLOGICAL: sterile saline for injection|BIOLOGICAL: MDX-1100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Lanthanum Carbonate on Fibroblast Growth Factor 23
Status: UNKNOWN
Conditions: Other Nonspecific Abnormal Serum Enzyme Levels
Interventions: DRUG: Lanthanum carbonate|DRUG: Calcium Carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transfer of Effector Memory T Cells (Tem) Following Allogeneic Stem Cell Transplantation
Status: UNKNOWN
Conditions: Lymphoma|Leukemia|Myeloma|Myelodysplastic Syndromes|Severe Aplastic Anemia|Primary Immune Deficiency|Graft Vs Host Disease
Interventions: BIOLOGICAL: CD62L- Tem
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Sildenafil on Choroidal Thickness in AMD
Status: TERMINATED
Conditions: Age-related Macular Degeneration
Interventions: DRUG: Sildenafil citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Flavopiridol Plus Cisplatin or Carboplatin in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Breast Cancer|Melanoma (Skin)|Prostate Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: alvocidib|DRUG: carboplatin|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Impact of Dosimeter on Measurement of Airway Responsiveness to Methacholine
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: methacholine|DEVICE: KoKo Digidoser|DEVICE: Rosethal Dosimeter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Electrical Vestibular Nerve Stimulation (VeNS) in the Management of Obesity: A Randomized Clinical Trial
Status: COMPLETED
Conditions: Obesity
Interventions: DEVICE: Vestal device|BEHAVIORAL: Lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Support for Progress (PSP) in a VA Women's Wellness Clinic
Status: COMPLETED
Conditions: Psychological Stress|Life Stress|Emotional Stress
Interventions: BEHAVIORAL: Personalized Support for Progress
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: EMPOWERing Patients With Chronic Diseases Through Smartphone App, Health Coaching and Shared Decision Making
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2|Hypertension
Interventions: BEHAVIORAL: Nudge, health coaching and shared decision-making
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Examining the Effectiveness of Two Behavioral Interventions for Sleep Problems in Infants
Status: RECRUITING
Conditions: Insomnia
Interventions: BEHAVIORAL: bedtime intervention for early childhood insomnia|BEHAVIORAL: bedtime and nighttime intervention for early childhood insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Of The Effects Of Inspiratory Muscle Training Methods in Mechanically Ventilated Patients
Status: RECRUITING
Conditions: Mechanical Ventilation|Intensive Care Units
Interventions: DEVICE: Mechanical Ventilation Device|DEVICE: External Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of ABT-869 in Subjects With Advanced Non-small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: ABT-869 .25 mg/kg|DRUG: ABT-869 0.10 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MagniXene MRI Use in Patients With Asthma and COPD to Assess Regional Lung Function by Delineating Ventilation Defects
Status: COMPLETED
Conditions: Asthma|COPD|Healthy
Interventions: DRUG: HXe MRI lung ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treatment of Imminent Haematological Relapse in Patients With AML and MDS Following Allogeneic Stem Cell Transplantation With 5-azacitidine (Vidaza®)
Status: COMPLETED
Conditions: Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: 5-Azacytidin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Immunogenicity of a SARS-CoV-2 mRNA Vaccine Booster
Status: COMPLETED
Conditions: SARS-CoV-2
Interventions: BIOLOGICAL: SARS-CoV-2 mRNA vaccine (RBMRNA-405)|BIOLOGICAL: CoronaVac®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Frontline Therapy Trial in Participants With Advanced Classical Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: DRUG: brentuximab vedotin|DRUG: doxorubicin|DRUG: bleomycin|DRUG: vinblastine|DRUG: dacarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Immunogenicity of the Norovirus GI.1/GII.4 Bivalent Virus-like Particle (VLP) Vaccine (NoV Vaccine) in Adults
Status: COMPLETED
Conditions: Healthy Volunteers|Norovirus
Interventions: BIOLOGICAL: NoV Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Observation of CABA System in the Treatment of End-stage Liver Disease With Inflammation
Status: RECRUITING
Conditions: To Evaluate the Clinical Efficacy and Safety of the New ALSS
Interventions: DEVICE: New artificial liver CABA system (BS330+CA280) +PE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Dexmedetomidine With Bupivacaine Versus Bupivacaine Alone for Caudal Block in Supra - Umbilical Surgeries
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Dexmedetomidine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparing Treatment Completion Of Daily Rifapentine & Isoniazid For One Month (1HP) To Weekly High Dose Rifapentine & Isoniazid For 3 Months (3HP) In Persons Living With HIV and in Household Contacts of Recently Diagnosed Tuberculosis Patients
Status: RECRUITING
Conditions: HIV Seropositivity|Tuberculosis|Household Contact
Interventions: DRUG: Daily rifapentine and isoniazid for 4 weeks|DRUG: Weekly rifapentine and isoniazid for 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effects of Calorie Restriction With or Without Metformin on Weight and Insulin Resistance
Status: COMPLETED
Conditions: Body Weight|Insulin Resistance
Interventions: DRUG: metformin|BEHAVIORAL: "standard diet advice"|BEHAVIORAL: "personal diet advice"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Healthy Lifestyle Before and During Pregnancy to Prevent Childhood Obesity - the PRE-STORK-trial
Status: RECRUITING
Conditions: Overweight and Obesity|Pregnancy Related
Interventions: BEHAVIORAL: Diet|BEHAVIORAL: Exercise|BEHAVIORAL: Mentorship
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy, Safety, and Dose-response of a Live Biotherapeutic Product in Women With Acute Vaginal Infection
Status: NOT_YET_RECRUITING
Conditions: Bacterial Vaginosis|Vulvovaginal Candidiasis
Interventions: DRUG: BGY-1601-VT|OTHER: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Palmoplantar Pustular Psoriasis Efficacy and Safety With Secukinumab
Status: COMPLETED
Conditions: Palmoplantar Pustular Psoriasis
Interventions: BIOLOGICAL: Secukinumab 300mg|BIOLOGICAL: Secukinumab 150mg|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does ACL Augmented With LEAT Better Controls Rotational Laxity Than Isolated ACL Reconstruction?
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Injuries
Interventions: PROCEDURE: Isolated ACL reconstruction|PROCEDURE: ACL + LEAT reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Medico-economic Evaluation of a Rapid Test (ePlex-BCID®, GenMark) for the Diagnosis of Bacteremia and Fungemia.
Status: COMPLETED
Conditions: Bacteremia Sepsis|Fungemia
Interventions: DIAGNOSTIC_TEST: Multiplex PCR|DIAGNOSTIC_TEST: Current strategy alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Immersive Virtual Reality for Dual-task Training in Older Adults With Mild Cognitive Impairment: A Randomized Controlled Trial
Status: RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: OTHER: Cognitive-motor dual task training (DTT)|OTHER: Cognitive single task training (CSTT)|OTHER: Motor single task training (MSTT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Geriatric Assessment Reporting in Real Time (GARRT) in Non-electively Hospitalized Older Cancer Patients
Status: COMPLETED
Conditions: Oncology
Interventions: OTHER: Results of the brief geriatric assessment|OTHER: No results of brief geriatric assessments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Cotrimoxazole Use in Immunocompetent HIV Patients on Carriage of Antimicrobial Resistant Bacteria
Status: COMPLETED
Conditions: HIV-1-infection|Pneumocystis Pneumonia|Opportunistic Infections|Preventive Therapy|Antibiotic Side Effect
Interventions: DRUG: Cotrimoxazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Evaluation of a Standard Treatment Regimen of Anti-tuberculosis Drugs for Patients With MDR-TB
Status: COMPLETED
Conditions: MDR-TB
Interventions: DRUG: Regimen A locally-used WHO-approved MDR-TB regimen (2011 guideline)|DRUG: Moxifloxacin|DRUG: Clofazimine|DRUG: Ethambutol|DRUG: Pyrazinamide|DRUG: Isoniazid|DRUG: Prothionamide|DRUG: Kanamycin|DRUG: Levofloxacin|DRUG: Bedaquiline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Nivolumab and DHAP in Patients With Relapsed or Refractory Classical Hodgkin Lymphoma (Nivo-DHAP)
Status: COMPLETED
Conditions: Hodgkin Lymphoma
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eye Tracking as a Predictor of Methylphenidate Response in Autism With ADHD
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Methylphenidate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of RC48-ADC in Local Advanced or Metastatic Gastric Cancer With the HER2-Overexpression
Status: RECRUITING
Conditions: Gastric Cancer|HER2 Overexpressing Gastric Carcinoma
Interventions: DRUG: RC48-ADC|DRUG: Paclitaxel injection|DRUG: Irinotecan Hydrochloride Injection|DRUG: Apatinib Mesylate Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Pellevé™ Neck Wrinkle Study
Status: COMPLETED
Conditions: Facial and Neck Rhytides
Interventions: DEVICE: Pelleve Wrinkle Treatment System - includes the Pelleve Handpiece and S5 generator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRednisone Plus EVerolimus in Patients With Metastatic Renal Cell Cancer After Failure of VEGFR -TKI
Status: TERMINATED
Conditions: Metastatic Renal Cancer
Interventions: DRUG: Prednisone + Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre- and Postoperative Nutrition in Head and Neck Cancer Patients
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DIETARY_SUPPLEMENT: Nutritional supplement (Protein + MIX)|DIETARY_SUPPLEMENT: Nutritional supplement (Protein)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability, Pharmacokinetics and Immunogenicity Trial of Co-administered MERS-CoV Antibodies REGN3048 and REGN3051
Status: COMPLETED
Conditions: Corona Virus Infection
Interventions: OTHER: Placebo|BIOLOGICAL: REGN3048|BIOLOGICAL: REGN3051
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Functional and Structural Outcomes in Neovascular Age-related Macular Degeneration
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Standard of Care Chemotherapy Plus Pembrolizumab for Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Paclitaxel|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myocardial Perfusion Imaging Galmydar Rest/Stress
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DRUG: Ga-68 Galmydar|DRUG: 13N-ammonia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 3 Extension Study to Investigate the Long-term Safety, Tolerability and Efficacy of PA21, a Phosphate Binder in Dialysis Patients
Status: COMPLETED
Conditions: Chronic Kidney Disease Requiring Chronic Dialysis
Interventions: DRUG: PA21 (2.5 g tablet containing 500 mg iron)|DRUG: Sevelamer carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Experimental Sleep Disturbances on Receptor Function of Study Drug
Status: RECRUITING
Conditions: Sleep Disorder|Healthy
Interventions: BEHAVIORAL: Sleep Fragmentation|DRUG: Within-Subject test of blinded study medication (stimulant, benzodiazepine, opioid, cannabinoid, over-the-counter pain medication, or placebo)|BEHAVIORAL: Sleep Continuity Disruption|BEHAVIORAL: Undisturbed Sleep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Metformin Hydrochloride in Treating Women With Stage I or Stage II Breast Cancer That Can Be Removed By Surgery
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: metformin hydrochloride|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Design and Development of a Mobile App to Improve Adherence to Pre-exposure Prophylaxis in Men Who Have Sex With Men
Status: COMPLETED
Conditions: HIV Infections|Pre-Exposure Prophylaxis
Interventions: BEHAVIORAL: mobile app to improve adherence to PrEP self-management
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TEAMS-BP (The Enhancement of Social Networks to Augment Management of Stroke-Blood Pressure)
Status: TERMINATED
Conditions: Stroke, Acute Ischemic|Hypertension
Interventions: OTHER: Social Network Group Counseling|OTHER: Individual Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Pharmacokinetics of Oral Dextran Sulfate (UA001) and Intravenous Dextran Sulfate in Healthy Volunteers
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Dextran sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin in Step-down Regimen Versus Conventional Low Dose Step-up Protocol in Patients With PCOS Undergoing IVF
Status: UNKNOWN
Conditions: Infertility|PCOS
Interventions: DRUG: Metformin, gonadotropins in step-down regimen|DRUG: Placebo, gonadotropins in step-up regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 1 Study to Evaluate the Effects of Fluconazole and Atorvastatin on the Pharmacokinetics of TAK-385 in Healthy Subjects
Status: COMPLETED
Conditions: Prostate Cancer|Endometriosis
Interventions: DRUG: TAK-385|DRUG: Fluconazole|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating a First Line Combination Therapy With Raltegravir, Emtricitabine and Tenofovir in HIV-2 Infected Patients
Status: COMPLETED
Conditions: HIV-2 Infection
Interventions: DRUG: emtricitabine / tenofovir disoproxil fumarate / raltegravir .
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Safety, Tolerability and Pharmacokinetic of Multiple Ascending Doses of VV119
Status: RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: VV119 Placebo （in healthy adult subjects）|DRUG: VV119 （in healthy adult subjects）|DRUG: VV119(in adult patients with schizophrenia)|DRUG: VV119 Placebo （in adult patients with schizophrenia）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Plasma Copeptin in Response to Oral Urea in Healthy Adults and Patients With Polyuria-polydipsia Syndrome
Status: COMPLETED
Conditions: Arginine Vasopressin Deficiency|Primary Polydipsia
Interventions: DIAGNOSTIC_TEST: Urea|DIAGNOSTIC_TEST: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Neoadjuvant Study of Sintilimab Plus Platinum Doublet Chemotherapy in IIIA(N2) Stage NSCLC
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Biological: Sintilimab Drug: Cisplatin Drug: Paclitaxel for Injection (Albumin Bound) Drug: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Ablation of Long-standing Persistent AF During CABG
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Biatrial radiofrequency ablation and CABG|PROCEDURE: Left atrial radiofrequency ablation and CABG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Nicotinamide Riboside on the Clinical Outcome of Covid-19 in the Elderly
Status: WITHDRAWN
Conditions: COVID
Interventions: DIETARY_SUPPLEMENT: Nicotinamide riboside|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Pelvic Floor Rehabilitation Combined With Ultrasound Therapy on Osteomyoarticular Symptoms in Chronic Perineal Pain
Status: COMPLETED
Conditions: Chronic Perineal Pain|Pelvic Floor Disorders
Interventions: DEVICE: Traditional ultrasound therapy|OTHER: Pelvic floor rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lycopene in Treating Patients With Prostate Cancer or Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Nonmalignant Neoplasm|Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: lycopene|OTHER: laboratory biomarker analysis|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Demonstrate Bioequivalence Between 6 ? 2-mg Tablets of Perampanel and a Single 12-mg Tablet of Perampanel in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Perampanel|DRUG: Perampanel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of a Nationwide Cognitive-Affective Remediation Training Intervention in Depression
Status: TERMINATED
Conditions: Cognitive-affective Exercises|Engaging Exercises
Interventions: OTHER: Therapeutic Computerized intervention|OTHER: Nontherapeutic computerized intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Intravenous Acetaminophen on Post-Operative Pain After Craniotomy
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Acetaminophen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Novel Formulations of Topical Calcipotriol in Patients With Mild to Moderate Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: AKVANO-Calcipotriol formulation 1|DRUG: AKVANO-Calcipotriol formulation 2|DRUG: AKVANO vehicle formulation 1|DRUG: AKVANO vehicle formulation 2|DRUG: Daivonex solution|DRUG: Daivonex cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Extended-release Guanfacine Hydrochloride in Children and Adolescents Aged 6-17 Years With Attention-Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Extended-release Guanfacine Hydrochloride|DRUG: Atomoxetine Hydrochloride|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Perfusion Magnetic Resonance Imaging in Measuring the Growth of Blood Vessels in Newly Diagnosed Brain Tumors
Status: WITHDRAWN
Conditions: Brain and Central Nervous System Tumors
Interventions: OTHER: laboratory biomarker analysis|PROCEDURE: biopsy|PROCEDURE: magnetic resonance imaging|RADIATION: gadopentetate dimeglumine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Plant Sterols and Stanols on Liver Inflammation
Status: UNKNOWN
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: DIETARY_SUPPLEMENT: Margarine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Glucose Homeostasis in Pseudohypoparathyroidism
Status: TERMINATED
Conditions: Pseudohypoparathyroidism and Pseudopseudohypoparathyroidism|Pseudohypoparathyroidism Type Ia|Albright Hereditary Osteodystrophy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Quetiapine Fumarate (Seroquel) as Mono-Therapy or Adjunct to Lithium in the Treatment of Patients With Acute Mania in Bipolar Disorder
Status: COMPLETED
Conditions: Acute Mania in Bipolar Disorder
Interventions: DRUG: Quetiapine Fumarate|DRUG: Lithium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Lappa Arctium (Homoeopathic Medicine) in Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Lappa Arctium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Dosing Regimen of Pyrotinib in HER2-positive Advanced First-line Breast Cancer: a Phase II Clinical Study
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Pyrotinib dose escalation|DRUG: Pyrotinib dose normal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Sacral Neuromodulation (SNM) in the Treatment of Active Ulcerative Colitis (PRIMICISTIM)
Status: COMPLETED
Conditions: Active Ulcerative Colitis
Interventions: DEVICE: InterStim II Neurostimulator Model 3058
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effect of Nivolumab for Patients With In-transit Metastases Treated With Isolated Limb Perfusion
Status: RECRUITING
Conditions: Melanoma|In-Transit Metastasis
Interventions: DRUG: Nivolumab|PROCEDURE: Isolated limb perfusion (ILP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Evaluate the Efficacy and Safety of TNX-102 SL in Patients With Multi-Site Pain Associated With Post-Acute Sequelae of SARS-CoV-2 Infection
Status: COMPLETED
Conditions: Post-Acute Sequelae of SARS-CoV-2 (PASC) Infection|COVID-19|Long COVID|Long Haul COVID
Interventions: DRUG: TNX-102 SL|DRUG: Placebo SL Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effectiveness and Safety of Infliximab in Chinese Patients With Active Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Infliximab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Strength Training Protocol in Fibromyalgia Women
Status: NOT_YET_RECRUITING
Conditions: Fibromyalgia|Fatigue|Fatigue; Muscle, Heart|Strength Training|Stress
Interventions: BEHAVIORAL: FMG (Fibromyalgia group)|BEHAVIORAL: HG (Healthy group)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: EPASS Versus Uncovered Duodenal Stent for Unresectable Malignant Gastric Outlet Obstruction.
Status: COMPLETED
Conditions: Gastric Outlet Obstruction
Interventions: DEVICE: EUS-guided gastrojejunstomy|DEVICE: The pyloro-duodenal stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Memories and Level of Sedation for Tracheal Intubation Using Fiberoptic Bronchoscopy/Videolaryngoscopy
Status: RECRUITING
Conditions: Difficult Airway|Postoperative Memories|Tracheal Intubation
Interventions: OTHER: Sedation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Different Noradrenaline Protocols in Post Spinal Hypotension in CS
Status: COMPLETED
Conditions: Hypotension|Cesarean Section|Anesthesia, Spinal
Interventions: DRUG: Noradrenalin 10 microgram bolus|DRUG: Noradrenaline 5 microgram bolus|DRUG: Noradrenaline 0.1 microgram/kg/minute infusion|DRUG: Noradrenaline 0.05 microgram/kg/minute infusion|DRUG: Infusion dosage: 0.075 microgram/kg/minute infusion|PROCEDURE: Spinal anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Hydrodissection in Carpal Tunnel Syndrome
Status: RECRUITING
Conditions: Carpal Tunnel Syndrome
Interventions: PROCEDURE: Ultrasound guided median nerve hydrodissection injection with Hyaluronic acid|PROCEDURE: Ultrasound guided median nerve hydrodissection injection with Dextrose water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of a Silicone Hydrogel Daily Wear Monthly Replacement Contact Lens
Status: COMPLETED
Conditions: Refractive Errors
Interventions: DEVICE: Lehfilcon A contact lenses|DEVICE: Comfilcon A contact lenses|DEVICE: CLEAR CARE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Structured Home-based Exercise Versus Walking Advice in Claudication Patients: a Randomized-controlled Trial
Status: UNKNOWN
Conditions: Peripheral Artery Disease
Interventions: BEHAVIORAL: Structured home-based exercise|BEHAVIORAL: Walking advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ascitic Fluid Microbiome in Liver Cirrhosis
Status: WITHDRAWN
Conditions: Ascitic Fluid, Microbiota|Microbiota|Sequence Analysis|Polymerase Chain Reaction
Interventions: OTHER: Ascitic fluid puncture|OTHER: Skin swaps from puncture side|OTHER: Stool samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Pharmacokinetics of the Current Capsule Formulation of CORT125134 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CORT125134 150 mg|DRUG: CORT125134 250 mg|DRUG: CORT125134 dose to be determined
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Investigate the Effects of BMS-986278 on Drospirenone and Ethinyl Estradiol Drug Levels in Healthy Female Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: BMS-986278|DRUG: Drospirenone/Ethinyl Estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inpatient Challenge Study of rRSV A/Maryland/001/11, a Human Respiratory Syncytial Virus Challenge Strain, Administered to Healthy Adult Volunteers
Status: RECRUITING
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: rRSV A/Maryland/001/11
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION