pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety of Stempeucel® in Patients With Critical Limb Ischemia (CLI) Due to Buerger's Disease
Status: RECRUITING
Conditions: Critical Limb Ischemia|Buerger's Disease
Interventions: BIOLOGICAL: Adult human bone marrow derived, cultured, pooled, allogeneic mesenchymal stromal cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 10-Years Follow-up of the EXAMINATION Trial
Status: COMPLETED
Conditions: Myocardial Infarction|ST Elevation Myocardial Infarction|Infarction|Necrosis|Heart Disease|Cardiovascular Diseases|Vascular Diseases
Interventions: DRUG: Everolimus Eluting Coronary Stent System|DEVICE: Cobalt chromium balloon expandable stent (non-drug-eluting stent Arm)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Using Allopurinol to Relieve Symptoms in Patients With Heart Failure and High Uric Acid Levels
Status: COMPLETED
Conditions: Heart Failure|Elevated Serum Uric Acid
Interventions: DRUG: allopurinol|DRUG: sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of DX-88 (Ecallantide) to Treat Acute Attacks of Hereditary Angioedema (HAE)
Status: COMPLETED
Conditions: Hereditary Angioedema (HAE)
Interventions: DRUG: ecallantide|DRUG: Phosphate Buffer Saline (PBS), pH 7.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Tolerability of NP101 Patch in the Treatment of Acute Migraine
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: DRUG: NP101 - Sumatriptan iontophoretic transdermal patch|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sleep Apnea Treatment After Stroke (SATS)
Status: TERMINATED
Conditions: Obstructive Sleep Apnea|Stroke
Interventions: DEVICE: continuous positive airway pressure or CPAP|DEVICE: sham CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: New Treatment Algorithm to Reduce Spherical Aberration After LASIK Correction for Myopia
Status: COMPLETED
Conditions: Myopia|Astigmatism
Interventions: DEVICE: VSS-Rx1 OPM vs Commercial iDesign Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Verification of the Epidemiology and Mortality of Rare Diseases in Taiwan With Real-world Evidence
Status: COMPLETED
Conditions: Rare Diseases|Epidemiology|Morbidity|Morality|Comorbidities and Coexisting Conditions|Health Care Utilization
Interventions: OTHER: longitudinal observational study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of hzVSF-v13 in Moderate to Severe Patients With COVID-19 Pneumonia
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: hzVSF-v13|DRUG: Placebo (Normal saline solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Home Based Exercise in Preventing Fall and Improving Balance in Older People
Status: COMPLETED
Conditions: Patient Fall|Muscle Balance|Fear of Falling|Quality of Life
Interventions: BEHAVIORAL: Home based exercise|OTHER: fall prevention education and counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ph.D.-Project: Eustachian Tube Dysfunction: Causes, Diagnosis, Treatment, and Prognosis
Status: RECRUITING
Conditions: Eustachian Tube Dysfunction|Middle Ear Disease|Hearing Loss, Conductive|Middle Ear Problem
Interventions: PROCEDURE: Balloon Eustachian Tuboplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Music Combined With Sports Games on Alleviating Psychological Stress, Anxiety and Mental Energy Among Adolescents During COVID-19 Pandemic in Lanzhou Gansu Province China
Status: COMPLETED
Conditions: Stress|Anxiety and Fear
Interventions: BEHAVIORAL: Music intervention only|BEHAVIORAL: Sports games intervention only|BEHAVIORAL: Music and sports games intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diacerein as Adjuvant to Diclofenac Sodium in Indian Patients of Osteoarthritis (OA) Knee
Status: COMPLETED
Conditions: Osteoarthritis|Osteoarthritis, Knee
Interventions: DRUG: diacerein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Curriculum Evaluation of a Novel Health and Wellness Program Within New York City Schools
Status: COMPLETED
Conditions: Adolescent Behavior
Interventions: BEHAVIORAL: Yoga-informed Health and Wellness Program|BEHAVIORAL: Physical Education Class
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Provigil in Conjunction With SSRIs for the Treatment of Mild or Moderate Depression With Attendant Symptoms of Sleepiness and Fatigue.
Status: COMPLETED
Conditions: Major Depression|Mental Health
Interventions: DRUG: Provigil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Brain as a Therapeutic and Research Target in Trigeminal Neuropathic Pain
Status: COMPLETED
Conditions: Trigeminal Neuropathic Pain
Interventions: PROCEDURE: PET Scans|PROCEDURE: transcranial direct current stimulation (tDCS)|PROCEDURE: MRI|OTHER: sham tDCS (prior to real tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Appropriate Dose of Neostigmine for Reversal of Rocuronium and Cisatracurium
Status: COMPLETED
Conditions: Observation of Neuromuscular Block
Interventions: DRUG: Injection of neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study About Patient Satisfaction With Laser-sintered Removable Partial Dentures
Status: COMPLETED
Conditions: Partially Edentulous Jaws
Interventions: DEVICE: Laser-sintered removable partial denture|OTHER: cast removable partial dentures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Povidone-iodine Ophthalmic Surgical Prep Solution on Respiration in Children Undergoing Strabismus Surgery With General Anesthesia.
Status: COMPLETED
Conditions: Strabismus
Interventions: DRUG: Provodine-Iodine Solution|DRUG: Group B will receive three drops in each eye of ophthalmic balanced salt solution.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: BIIB014 Cardiovascular Monitoring Study
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Placebo|DRUG: BIIB014 50mg|DRUG: BIIB014 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Vitamin D Deficiency, Muscle Pain, Joint Pain, and Joint Stiffness in Postmenopausal Women Receiving Letrozole For Stage I-III Breast Cancer
Status: COMPLETED
Conditions: Arthralgia|Musculoskeletal Complications|Pain|Recurrent Breast Cancer|Stage I Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: DRUG: letrozole|DIETARY_SUPPLEMENT: calcium carbonate|OTHER: laboratory biomarker analysis|DIETARY_SUPPLEMENT: calcium citrate|DIETARY_SUPPLEMENT: calcium glucarate|DRUG: calcium gluconate|DIETARY_SUPPLEMENT: cholecalciferol|PROCEDURE: assessment of therapy complications|PROCEDURE: musculoskeletal complications management/prevention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TAXUS PERSEUS Workhorse
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Percutaneous coronary intervention (PCI) with paclitaxel-eluting stent (TAXUS Element) implantation|DEVICE: Percutaneous coronary intervention (PCI) with paclitaxel-eluting stent (TAXUS Express) placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Development of a Culturally Tailored Resilience-building Intervention for Chinese American's Advance Care Planning Discussions
Status: NOT_YET_RECRUITING
Conditions: Advance Care Planning|Neoplasms|Heart Diseases
Interventions: BEHAVIORAL: Culturally tailored resilience-building intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Combination Therapy of Gliclazide MR and Basal Insulin Versus Insulin Monotherapy to Treat Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Gliclazide MR and Insulin Glargine Injection|DRUG: Biosynthetic Human Insulin Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Patient Adherence to Stroke Rehabilitation Treatment
Status: RECRUITING
Conditions: Stroke Rehabilitation|Telerehabilitation|Decision Making, Shared
Interventions: OTHER: Telerehabilitation and team meetings and team care plans|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Reconstruction of Monocytic Immunocompetence by Granulocyte-macrophage-colony Stimulating Factor (GM-CSF) in Patients With Severe Sepsis and Septic Shock
Status: COMPLETED
Conditions: Sepsis
Interventions: BIOLOGICAL: GM-CSF (verum)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Topical Application of Vitamin B6 in Palmar-Plantar Erythrodysesthesia
Status: COMPLETED
Conditions: Palmar-Plantar Erythrodysesthesia
Interventions: DEVICE: Vitamin B6 cream|DEVICE: Placebo Vitamin B6 cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Viscoelastometry Guided Resuscitation During Burn Excision on Post Resuscitation Infections
Status: COMPLETED
Conditions: Burns
Interventions: PROCEDURE: Viscoelastic (VE) Guided Transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of RO6864018 in Male, Healthy, Asian Participants
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: RO6864018|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Homozygous Familial Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Alirocumab SAR236553 (REGN727)|DRUG: Atorvastatin|DRUG: Simvastatin|DRUG: Fluvastatin|DRUG: Pravastatin|DRUG: Lovastatin|DRUG: Rosuvastatin|DRUG: Ezetimibe|DRUG: Cholestyramine|DRUG: Nicotinic acid|DRUG: Fenofibrate|DRUG: Omega-3 fatty acids
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PixelShine vs. Iterative Reconstruction (IR) Processing of CT Images
Status: UNKNOWN
Conditions: Cancer, Lung|Cancer Liver|X-rays; Effects
Interventions: DEVICE: PixelShine|DEVICE: Conventional processing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of 18F-DCFBC PSMA-based PET Imaging for Detection of Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Metastatic Prostate Cancer
Interventions: DRUG: 18F-DCFBC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Electro- Hemodynamic Activity in Children: Combined Analysis by Video -EEG Spectroscopy and Near-infrared (NIRS )
Status: UNKNOWN
Conditions: Epilepsy
Interventions: DEVICE: Near Infra Red Spectroscopy (NIRS)|DEVICE: Electroencephalogram (EEG)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Safety and Tolerability of SSS11 in Healthy Subjects.
Status: UNKNOWN
Conditions: Gout
Interventions: BIOLOGICAL: SSS11|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repinotan in Patients With Acute Ischemic Stroke
Status: COMPLETED
Conditions: Stroke|Acute Ischemic Stroke
Interventions: DRUG: Repinotan HCl (BAYX3702)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Using Different Screwed Abutment Height
Status: ACTIVE_NOT_RECRUITING
Conditions: Bone Loss
Interventions: DEVICE: Dental implant placement with COVER SCREW (two surgeries in control group) or DEFINITIVE TRANSEPITHELIAL ABUTMENT (one surgery in test group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment for Non-Alcoholic Fatty Liver With Different Doses of Vitamin E
Status: COMPLETED
Conditions: Fatty Liver
Interventions: DRUG: Vitamin E 200 IU/d|DRUG: Vitamin E 400 IU/d|DRUG: Vitamin E 800 IU/d|BEHAVIORAL: Diet and Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Erector Spinae Plane Block in Post-operative Recovery in Cardiac Surgery With Median Sternotomy.
Status: COMPLETED
Conditions: Sternotomy|Postoperative Pain
Interventions: PROCEDURE: Ultrasound guided bilateral ESBP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Definition of Autonomic Nervous System Involvement in Patients With Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DIAGNOSTIC_TEST: quantification of sensory and autonomic small nerve fibers by punch skin biopsy|DIAGNOSTIC_TEST: Cardiovascular Reflexes testing|OTHER: Administration of clinical scales evaluating autonomic symptoms, pain small fiber neuropathy symptoms
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of the Modification of the Pharmacokinetic Profile of Levodopa by the Fiber Plantago Ovata Husk
Status: COMPLETED
Conditions: Parkinson's Disease, Idiopathic
Interventions: DRUG: Plantago ovata husk|OTHER: hemicellulose crystalline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Non-invasive Brian Stimulation on Language Production in Healthy Older Adults
Status: COMPLETED
Conditions: Language Disorders|Aphasia|Stroke
Interventions: DEVICE: Transcranial direct-current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Physical Therapy Program Versus Surgery for Femoroacetabular Impingement: Randomized Clinical Trial
Status: COMPLETED
Conditions: Femoroacetabular Impingement
Interventions: PROCEDURE: Arthroscopic Surgery|PROCEDURE: Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: National Ophthalmic Genotyping and Phenotyping Network (eyeGENE (Registered Trademark)), Stage 3 - Expansion of DNA and Data Repositories for Rare Inherited Ophthalmic Diseases
Status: RECRUITING
Conditions: Inherited Ophthalmic Diseases|Hypopigmentation Disorder|Corneal Dystrophy|Blue-cone Monochromacy|Best Disease|Aniridia|Albinism
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Halitosis After Treatment With Photodynamic Therapy Associated With Periodontal Treatment
Status: COMPLETED
Conditions: Halitosis
Interventions: DEVICE: Pdt Photodynamic Therapy|OTHER: tongue scrapper
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence of Human Immunodeficiency Virus-1 (HIV-1) Infection in HIV-1 Uninfected High Risk Men Who Have Sex With Men
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus|HIV Infections
Interventions: BEHAVIORAL: Risk reduction counseling|OTHER: Social harm interview|OTHER: Computer-Assisted Self Interviewing technique
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Do Arterial Catheters Reduce the Risk of Major Perioperative Complications
Status: COMPLETED
Conditions: Postoperative Complications
Interventions: PROCEDURE: non-cardiac surgery|OTHER: arterial catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Diurnal Variation of Exercise on Metabolic Health
Status: COMPLETED
Conditions: Aerobic Exercise|Acute Exercise|Circadian Rhythm Sleep-Wake Disorders, Unspecified Type|Glucose Metabolism|Lipid Metabolism|Diurnal Variation|Young Adults
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Novel Intervention for Amphetamine-type Stimulants Addiction
Status: COMPLETED
Conditions: Amphetamine Addiction
Interventions: RADIATION: repetitive transcranial magnetic stimulation (rTMS)|RADIATION: sham repetitive transcranial magnetic stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: KAATSU Training to Enhance Physical Function of Older Adults With Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: BEHAVIORAL: Resistance Exercise|BEHAVIORAL: KAATSU exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Kunxian for the Treatment of Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Kunxian Capsule|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Levetiracetam Add-On Treatment in Refractory Pediatric Patients With Partial Onset Seizures
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Levetiracetam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SaeboGlove Therapy for Severe Upper Limb Disability and Severe Hand Impairment After Stroke
Status: SUSPENDED
Conditions: Stroke
Interventions: DEVICE: SaeboGlove therapy|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of BNG-1 to Treat Acute Ischemic Stroke
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: BNG-1|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Graphene Photothermal Adjuvant Therapy for Mild Corona Virus Disease 2019: A Prospective Randomized Controlled Trial
Status: RECRUITING
Conditions: COVID-19
Interventions: DEVICE: Graphene spectrum light wave therapy room
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blocks for Intertrochanteric Fracture Repair Surgery
Status: UNKNOWN
Conditions: Intertrochanteric Fractures
Interventions: OTHER: General anesthesia|OTHER: Regional anesthesia- femoral and lateral femoral cutaneous nerve blocks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment
Status: TERMINATED
Conditions: Axial Spondyloarthritis
Interventions: BIOLOGICAL: Adalimumab|OTHER: Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Safety, Tolerability and Pharmacological Effects of PU AD in Subjects With Mild AD Dementia
Status: TERMINATED
Conditions: Alzheimer Disease
Interventions: RADIATION: Tau Positron emission tomography (PET)|RADIATION: Fluorodeoxyglucose (FDG) Positron emission tomography (PET)|DIAGNOSTIC_TEST: Cerebrospinal fluid (CSF) Biomarkers|DIAGNOSTIC_TEST: Blood Biomarkers|BEHAVIORAL: Rating Scales|DRUG: PU-AD|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Relevance of the Use of Peripheral Venous Blood Gases for the Care of Patients in the S.A.U.V (Vital Emergency Rooms) of the CHU de Caen
Status: COMPLETED
Conditions: Critical Illness
Interventions: OTHER: peripheral venous blood gases
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Fasting on ICSI Outcomes in Patients With Polycystic Ovary Syndrome
Status: WITHDRAWN
Conditions: Infertility|Polycystic Ovary Syndrome
Interventions: BEHAVIORAL: Fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Toripalimab Plus Nimotuzumab in Oral Squamous Cell Carcinoma Prior to Radical Therapy
Status: NOT_YET_RECRUITING
Conditions: Oral Squamous Cell Carcinoma
Interventions: DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect and Cost-effectiveness of the Everyday Life Rehabilitation Intervention
Status: RECRUITING
Conditions: Psychiatric or Mood Diseases or Conditions|Neuropsychiatric Syndrome|Psychosis|Autism|Severe Mental Disorder
Interventions: OTHER: Everyday Life Rehabilitation (ELR)|OTHER: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Vitamin D to Prevent Severe Asthma Exacerbations (Vit-D-Kids Asthma)
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: vitamin D3 4000 IU|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Study Comparing Treatment With Drug(s) or Adjunctive VNS Therapy for Pharmacoresistant Partial Seizures
Status: TERMINATED
Conditions: Epilepsies, Partial
Interventions: DEVICE: Vagus Nerve Stimulation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) as a Treatment for Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DEVICE: rTMS active treatment|DEVICE: rTMS sham treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Xevinapant (Debio 1143) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX)
Status: ACTIVE_NOT_RECRUITING
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Xevinapant (Debio 1143)|DRUG: Cisplatin|RADIATION: Intensity Modulation Radiation Therapy (IMRT)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study for an Isotretinoin
Status: COMPLETED
Conditions: Skin Infections (Acne)
Interventions: DRUG: Isotretinoin 40 mg|DRUG: Isotretinoin 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Efficacy of Different Gingival Displacement Methods Before Definitive Digital Impression
Status: COMPLETED
Conditions: Gingival Displacement
Interventions: DEVICE: Laser troughing|OTHER: Retraction cord and astringent|OTHER: Cordless retraction paste with astringent|OTHER: Cordless retraction paste without astringent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Study of Inflammation on Blood Glucose Levels in Obese People
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: salsalate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of CCX282-B in Subjects With Moderate to Severe Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: CCX282-B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Leuven Protocol With the Glucommander for Postoperative Control of Blood Glucose With IV Insulin
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: insulin regular IV infusion|DRUG: IV insulin infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fosaprepitant Versus Aprepitant in the Prevention of Chemotherapy Induced Nausea and Vomiting
Status: COMPLETED
Conditions: Ovarian Cancer|Uterine Cancer
Interventions: DRUG: fosaprepitant|DRUG: aprepitant|OTHER: Oral Placebo|OTHER: IV placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Erbium Laser for Extraction of the Third Molars
Status: NOT_YET_RECRUITING
Conditions: Third Molar Extraction|Impacted Third Molar Tooth
Interventions: PROCEDURE: Third molar extraction by cutting and rotary tools|PROCEDURE: Third molar extraction by erbium laser with wavelength 2.94 nm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RemImazolam Besylate for ICU-sedation in Patients With Mechanical Ventilation After Oral and Maxillofacial Surgery
Status: RECRUITING
Conditions: Remimazolam Besylate|Sedation|ICU
Interventions: DRUG: Remimazolam Besylate|DRUG: Propofol|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Randomized Open-label Study of Diammonium Glycyrrhizinate Enteric-coated Capsule Plus DXM Versus DXM in Treatment of ITP
Status: UNKNOWN
Conditions: Immune Thrombocytopenia
Interventions: DRUG: dexamethasone|DRUG: diammonium glycyrrhizinate enteric-coated capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduction in Symptomatic Esophageal Stricture Formation
Status: TERMINATED
Conditions: Esophageal Stenosis
Interventions: DRUG: prednisone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Contrast Enhanced Three Dimensional Echocardiographic Quantification of Right Ventricular Volumes in Repaired Congenital Heart Disease
Status: COMPLETED
Conditions: Tetralogy of Fallot|Pulmonary Insufficiency
Interventions: DRUG: Sulfur Hexafluoride Lipid Type A Microspheres 25 MG Injection Powder for Suspension [LUMASON]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Real-world Observation of Medical Accuracy of a Novel AI-app
Status: COMPLETED
Conditions: Gastrointestinal Issues|Respiratory Issues|Cardiovascular Issues|Genitourinary Issues|Musculoskeletal Issues|ENT Issues|Eye Issues|Neurologic Issues|Mental Health Issues
Interventions: DEVICE: Ada WRA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Different ARA Formulations of Infant Formula on Fatty Acid Status, Immune Markers and Infection Rates in Infants
Status: COMPLETED
Conditions: Healthy Infants
Interventions: DIETARY_SUPPLEMENT: combination ARA + DHA|DIETARY_SUPPLEMENT: DHA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Capnography Prevent Hypoxemia During Endoscopic Retrograde Cholangiopancreatography and Endoscopic Ultrasound?
Status: COMPLETED
Conditions: Hypoxemia
Interventions: DIAGNOSTIC_TEST: Capnography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Ustekinumab for the Prevention of Acute Graft-versus-Host Disease After Unrelated Donor Hematopoietic Cell Transplant
Status: RECRUITING
Conditions: Hematologic and Lymphocytic Disorder|Hematopoietic and Lymphoid System Neoplasm
Interventions: DRUG: Placebo Administration|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|BIOLOGICAL: Ustekinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lomecel-B on Vaccine-Specific Antibody- Response in Subjects With Aging Frailty
Status: COMPLETED
Conditions: Aging Frailty
Interventions: BIOLOGICAL: Longeveron Mesenchymal Stem Cells (LMSCs)|BIOLOGICAL: Fluzone High Dose Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Nitroglycerine on Microcirculatory Abnormalities During Sepsis
Status: COMPLETED
Conditions: Sepsis|Septic Shock
Interventions: DRUG: nitroglycerin iv|DRUG: placebo = nacl 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effectiveness of New Versus Older Treatments for Attention Deficit Hyperactivity Disorder (The NOTA Study)
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: Methylphenidate transdermal system|DRUG: Lisdexamfetamine dimesylate|DRUG: Osmotic-release oral system methylphenidate (OROS MPH)|DRUG: Mixed amphetamine salts extended release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Steady State Pharmacokinetics of Tacrolimus, Mycophenolate Mofetil and Fluvastatin After Renal Transplantation
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: Fluvastatin, Tacrolimus, Mycophenolat Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Two New Silicone Hydrogel Multifocal Products
Status: COMPLETED
Conditions: Presbyopia
Interventions: DEVICE: Lotrafilcon B multifocal contact lens|DEVICE: Senofilcon A multifocal contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Routine Chest Tube Management After Minimally Invasive Lung Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer
Interventions: OTHER: Low Suction Strategy of Chest Tube Management|OTHER: Standard Suction Strategy of Chest Tube Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-blind, Placebo-controlled, Randomized Clinical Trial Comparing the Efficacy and Safety of Sialanar Plus orAl rehabiLitation Against Placebo Plus Oral Rehabilitation for chIldren and Adolescents With seVere Sialorrhoea and Neurodisabilties,
Status: UNKNOWN
Conditions: Sialorrhea|Neurodevelopmental Disorders
Interventions: OTHER: Placebo|DRUG: Sialanar|OTHER: Oral Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sentinel Lymph Node Biopsy in Ocular Surface and Adnexal Cancers
Status: RECRUITING
Conditions: Ocular Sebaceous Carcinoma|Ocular Basal Cell Carcinoma|Ocular Surface Squamous Neoplasia|Merkel Cell Carcinoma, Unspecified|Porocarcinoma|Conjunctival Melanoma
Interventions: PROCEDURE: Sentinel Lymph Node Biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Performance Evaluation of Two Daily Disposable Toric Lens Designs in Habitual Soft Contact Lens Wearers
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: Lens A|DEVICE: Lens B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Desflurane Versus Propofol Anesthesia for Off-Pump CABG
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Diprivan (propofol), Astra-Zeneca|DRUG: Suprane (desflurane), Baxter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Tofacitinib in Patients With Prurigo Nodularis
Status: NOT_YET_RECRUITING
Conditions: Prurigo Nodularis|Itch
Interventions: DRUG: Tofacitinib 5 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Intraperitoneal Paclitaxel in Combination With SOX Compared With SOX Alone in Gastric Cancer With Malignant Ascites
Status: UNKNOWN
Conditions: Gastric Cancer|Stomach Neoplasms
Interventions: DRUG: Oxaliplatin|DRUG: Paclitaxel|DRUG: S-1 (Tegafur, Gimeracil and Oteracil Porassium Capsules)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Rifaximin With NAC in IBS-D
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Diarrhea
Interventions: DRUG: Rifaximin|DRUG: N-acetylcysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Immunotherapy-Ipilimumab-Nivolumab-Dendritic Cell p53 Vac - Patients With Small Cell Lung Cancer (SCLC)
Status: TERMINATED
Conditions: Small Cell Lung Cancer|Lung Cancer|Relapsed Small Cell Lung Cancer
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab|BIOLOGICAL: Dendritic Cell based p53 Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Decitabine and Tetrahydrouridine (THU) in Patients With Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: Oral Decitabine and Tetrahydrouridine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Safety and Tolerability of UCB0107 in Study Participants With Progressive Supranuclear Palsy (PSP)
Status: COMPLETED
Conditions: Progressive Supranuclear Palsy
Interventions: DRUG: bepranemab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gabapentin Pretreatment for Staged Bilateral Cataract Operations
Status: COMPLETED
Conditions: Hyperalgesia|Cataract Bilateral Nos
Interventions: DRUG: Gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nesfatin-1 Level in Patients With Type 2 Diabetes, Insulin Resistance and Obesity
Status: UNKNOWN
Conditions: Type 2 Diabetes|Insulin Resistance|Obesity|Nesfatin-1
Interventions: DIAGNOSTIC_TEST: Nesfatin-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Prognostic Value Related to the Presence of Thrombosis or Portal Vein Invasion in Patients With Hepatocellular Carcinoma Submitted to Surgery
Status: TERMINATED
Conditions: Hepatocellular Carcinoma|Portal Vein Thrombosis|Hepatic Portal Vein Tumor Invasion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reduction of Preoperative Anxiety in Children: Clickamico Project 2nd Phase
Status: COMPLETED
Conditions: Preoperative Anxiety
Interventions: PROCEDURE: Video|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety Study of the Monoclonal Antibody Teplizumab (MGA031) in Subjects With Moderate or More Severe Psoriasis
Status: TERMINATED
Conditions: Psoriasis
Interventions: BIOLOGICAL: teplizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial Comparing Lenalidomide With Low Dose Dexamethasone Versus Lenalidomide in Second Line Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Revlimid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhibition of Ovulation and Pharmacokinetics of Transdermal Ethinylestradiol (EE) and Gestodene (GSD)
Status: COMPLETED
Conditions: Contraception|Ovulation Inhibition
Interventions: DRUG: Ethinylestradiol/Gestodene (BAY86-5016)|DRUG: Ethinylestradiol/Gestodene (BAY86-5016)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Drug-Drug Interaction Between VX-787 and Oseltamivir
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: VX-787|DRUG: Oseltamivir|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Use of Memantine for Preserving Cognition in Adult Patients With Epilepsy
Status: WITHDRAWN
Conditions: Epilepsy
Interventions: DRUG: Memantine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: MLE4901 vs. Placebo for the Treatment of PCOS
Status: TERMINATED
Conditions: Polycystic Ovary Syndrome (PCOS)
Interventions: DRUG: MLE4901|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: nHFOV Versus Invasive Conventional Ventilation for Preterm Neonates With Respiratory Distress Syndrome
Status: WITHDRAWN
Conditions: Respiratory Distress Syndrome in Premature Infant
Interventions: DEVICE: Non-invasive High Frequency Oscillatory Ventilation|DEVICE: Conventional Invasive Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-Dose, Crossover Study To Compare Bioavailability Of Two Formulations Under Fed And Fasted Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxycodone|DRUG: Oxycodone|DRUG: Oxycodone|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Levothyroxine Treatment for Subclinical Hypothyroidism After Head and Neck Surgery
Status: WITHDRAWN
Conditions: Hypothyroidism|Neoplasms|Postoperative Complications
Interventions: DRUG: Levothyroxine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Subarachnoid Hyperbaric Bupivacaine in Obese Pregnant Patients Undergoing Cesarean Section
Status: RECRUITING
Conditions: Anesthesia|Obstetric Anesthesia Problems
Interventions: DRUG: 5mg bupivacaine|DRUG: 10mg bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neurophysiological and Immunological Effects of the Transition From Combustible to Electronic Cigarettes
Status: COMPLETED
Conditions: Tobacco Smoking|Nicotine Dependence
Interventions: OTHER: Electronic Cigarette|OTHER: Tobacco Cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Diet and Physical Activity Intervention for the Prevention of ADT-Induced Metabolic Changes in Patients With Prostate Cancer, TRIPLE-A PILOT Study
Status: RECRUITING
Conditions: Localized Prostate Carcinoma|Prostate Adenocarcinoma
Interventions: OTHER: Best Practice|OTHER: Dietary Intervention|OTHER: Exercise Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Validity of a Vibrating Postural Device for the Treatment of Positional Obstructive Sleep Apnea (Postural)
Status: COMPLETED
Conditions: OSA
Interventions: DEVICE: Group C-Postural device activated|DEVICE: Group B-Postural device no activated|BEHAVIORAL: Group A-General Recommendation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Plasticity in Stroke Patients With Severe Motor Deficit
Status: COMPLETED
Conditions: Stroke|Cerebrovascular Accident
Interventions: DEVICE: S88 Dual Output Stimulator by Grass Technologies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Hyaluronidase (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: Pembrolizumab coformulated with hyaluronidase|DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Nab-paclitaxel|BIOLOGICAL: Pembrolizumab|DRUG: Filgrastim|DRUG: Pegylated filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Impact of an Oral and Practical Presentation of Intrauterine Devices by a Health Professional on Women's Opinion as a Possible Contraceptive Method
Status: UNKNOWN
Conditions: Acceptance Processes
Interventions: OTHER: Group A, who will complete a questionnaire before receiving information about intrauterine devices|OTHER: Group B who will answer a questionnaire after having the information about the intrauterine devices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER