pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: EGF Ointment for Erlotinib Skin Lesion
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer|Pancreatic Cancer
Interventions: DRUG: Epidermal growth factor (EGF) ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effects of Tradipitant vs. Placebo in Atopic Dermatitis (EPIONE2)
Status: TERMINATED
Conditions: Atopic Dermatitis
Interventions: DRUG: Tradipitant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Can Risedronate Prevent Periprosthetic Bone Loss After Total Hip Arthroplasty
Status: COMPLETED
Conditions: Bone Loss
Interventions: DRUG: Risedronate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Effects on the Skin Microbiome of Amending an Over-the-counter Eczema Product With Activated Oil (AO)
Status: UNKNOWN
Conditions: Eczema
Interventions: OTHER: topical colloidal oatmeal formulation with a modified plant oil|OTHER: topical colloidal oatmeal formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Endoscopic Papillary Balloon Dilation on ERCP Complications
Status: COMPLETED
Conditions: Complications
Interventions: PROCEDURE: 30" group|PROCEDURE: 60" group|PROCEDURE: 180" group|PROCEDURE: 300" group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Abiprubart in Participants With Sjögren's Disease
Status: RECRUITING
Conditions: Sjögrens Disease
Interventions: DRUG: Abiprubart|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Lot-to-Lot Consistency Study to Evaluate Safety, Tolerability, and Immunogenicity of Inactivated Varicella Zoster Virus (VZV) Vaccine in Healthy Adults (V212-014)
Status: WITHDRAWN
Conditions: Herpes Zoster
Interventions: BIOLOGICAL: V212 Lot 1|BIOLOGICAL: V212 Lot 2|BIOLOGICAL: V212 Lot 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Single-arm Trial of Atezolizumab/Platinum/Etoposide for the Treatment of Advanced Large-cell Neuroendocrine Cancer of the Lung
Status: RECRUITING
Conditions: Large Cell Neuroendocrine Carcinoma of the Lung
Interventions: DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Pain and Anxiety Through Dietary Fiber Supplementation in Children With Abdominal Pain
Status: WITHDRAWN
Conditions: Functional Abdominal Pain Syndrome
Interventions: DIETARY_SUPPLEMENT: Psyllium|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Analysis of Levonorgestrel-Intrauterine System (LNG-IUS) Use in the Postpartum Period
Status: TERMINATED
Conditions: Contraception|Postpartum Period
Interventions: DEVICE: LNG-IUS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tele Health Monitoring Service for Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease, COPD
Interventions: DEVICE: Tele Monitoring, using Tunstall monitoring device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Will CPAP Reduce Length Of Respiratory Support In Premature Infants?
Status: TERMINATED
Conditions: Prematurity|Respiratory Distress Syndrome, Newborn
Interventions: DEVICE: CPAP|DEVICE: Mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare Meloxicam IM Once Daily and Meloxicam Administered Orally Once Daily in Patients With Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Meloxicam ampoule|DRUG: Meloxicam tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Anti-microbial Effect of Titanium Dioxide Nano Particles in Complete Dentures Made for Edentulous Patients
Status: UNKNOWN
Conditions: Candida Infection|Denture Stomatitis
Interventions: COMBINATION_PRODUCT: Titanium Dioxide Nanoparticles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Epigenetic Modification in OPRM1 on Postoperative Analgesia and Side Effect Induced by Sufentanil
Status: UNKNOWN
Conditions: Epigenetics
Interventions: DRUG: Sufentanil|DRUG: dexmedetomidine|DRUG: propofol|DRUG: Rocuronium|DRUG: sevoflurane|DRUG: remifentanil|DRUG: Parecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Prospective Study on the Use of Middle Meningeal Artery Embolization for Chronic Subdural Haematoma
Status: WITHDRAWN
Conditions: Chronic Subdural Hematoma|Subdural Hematoma
Interventions: PROCEDURE: Middle meningeal artery embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Safety and Immunogenicity of Synthetic DNAs Encoding a Native-like HIV Env Trimer and Interleukin-12 (INO-6160), Alone or in a Prime-boost Regimen With 3M-052-AF + Alum Adjuvanted VRC HIV Env Trimer 4571 in Adult Participants Without HIV
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV-1-infection
Interventions: BIOLOGICAL: INO-6160, 2 mg|BIOLOGICAL: Trimer-4571 / 100 mcg 3M-052-AF (5 mcg) + Alum (500 mcg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Oral Treprostinil in the Treatment of Calcinosis in Patients With Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis|Calcinosis
Interventions: DRUG: Oral treprostinil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MTD Study of Vaccine BP-GMAX-CD1 Plus AP1903 to Treat Castrate Resistant Prostate Cancer
Status: COMPLETED
Conditions: Castrate Resistant Prostate Cancer (CRPC)
Interventions: BIOLOGICAL: BPX-101|DRUG: AP1903
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluticasone and Salmeterol in Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: FLUTICASONE PROPRIONATE|DRUG: Salmeterol|DRUG: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Determine Percent Tissue Perfusion and Cellular Viability Using SPY Imaging
Status: COMPLETED
Conditions: Peripheral Vascular Disease
Interventions: DEVICE: SPY Imaging, ICG dye (0.2 - 0.5 mg/kg)|DEVICE: SPY Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Open-label Extension Study Evaluating Safety and Tolerability of LCZ696 in Subjects Who Completed PARAGON-HF in Japan.
Status: TERMINATED
Conditions: Heart Failure With Preserved Ejection Fraction (HFpEF)
Interventions: DRUG: LCZ696
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Fixed Dose Combination Dolutegravir/Abacavir/Lamivudine FDC Initiated During Acute HIV Infection
Status: COMPLETED
Conditions: HIV|Acute HIV Infection
Interventions: DRUG: Dolutegravir 50 mg|DRUG: Lamivudine 300 mg|DRUG: Abacavir 600 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled ZYESAMI (Aviptadil Acetate) for Treatment of Severe COVID-19
Status: WITHDRAWN
Conditions: SARS-CoV 2|COVID|ARDS|ALI|Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)|Dyspnea
Interventions: DRUG: ZYESAMI™ (aviptadil acetate)|DRUG: Placebo|DEVICE: Nebulized administration of ZYESAMI™ or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Leaders Free III: BioFreedom™ Clinical Trial
Status: COMPLETED
Conditions: Cardiac Death|Myocardial Infarction|Stent Thrombosis|Bleeding|Mortality
Interventions: DEVICE: BioFreedom™ BA9™ drug-coated stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Outcomes Assessment of the Utility of Belladerm Acellular Dermal Allograft in Ocular Lower Lid Retraction Repair
Status: COMPLETED
Conditions: Lower Eyelid Retraction
Interventions: PROCEDURE: Non Cadaveric Human Acellular Dermal Tissue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Analgesic Study to of V117957 for the Treatment of Postsurgical Pain Due to Third Molar Extraction
Status: TERMINATED
Conditions: Postsurgical Pain Due to Third Molar Extraction
Interventions: DRUG: V117957|DRUG: Ibuprofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Subcutaneous Daratumumab Regimens in Combination With Bispecific T Cell Redirection Antibodies for the Treatment of Participants With Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Daratumumab|DRUG: Talquetamab|DRUG: Teclistamab|DRUG: Pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D3 on Lung Function and Exercise Tolerance in COPD Patients
Status: COMPLETED
Conditions: Stable COPD Patients
Interventions: DRUG: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Assess the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Profiles of UCB5857 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: UCB5857|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Imatinib-Combined Chemotherapy for BCR-ABL-Positive Acute Lymphoblastic Leukemia (ALL)
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: imatinib|DRUG: cyclophosphamide|DRUG: daunorubicin|DRUG: vincristine|DRUG: prednisolone|DRUG: methotrexate|DRUG: cytarabine|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of the Bipolar Sealer Aquamantys 6.0 in Patients Undergoing Total Hip Arthroplasty
Status: COMPLETED
Conditions: Hip Arthritis
Interventions: DEVICE: Bipolar Radiofrequency (Aquamantys 6.0)|DEVICE: Standard Bovie Electrocautery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Investigating the Efficacy and Safety of Sepranolone in Women With Menstrual Migraine
Status: COMPLETED
Conditions: Menstrual Migraine
Interventions: DRUG: Sepranolone injection low dose|DRUG: Sepranolone injection high dose|DRUG: Placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: HDM201 and Pazopanib in Patients With P53 Wild-type Advanced/Metastatic Soft Tissue Sarcomas
Status: RECRUITING
Conditions: Advanced Soft-tissue Sarcoma|Metastatic Soft-tissue Sarcoma
Interventions: DRUG: Pazopanib|DRUG: HDM201
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Health Effects of a Blueberry Enriched Diet on Obese Children
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: Blueberry Smoothie|OTHER: Sham Smoothie
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of no Muscle Relaxant Versus Reduced-dose Rocuronium on Anesthesia in Adenotonsillectomy
Status: UNKNOWN
Conditions: Muscle Relaxants
Interventions: DRUG: Rocuronium bromide 0.15 mg kg-1|DRUG: Rocuronium bromide 0.3 mg kg-1|DRUG: Fentanyl|DRUG: Propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Candesartan Cilexetil/Amlodipine Besilate Combination Tablets LD, HD Special Drug Use Surveillance "Hypertension: Long-Term Use"
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Candesartan cilexetil/Amlodipine besilate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Self-management of Patients With Acute Coronary Syndromes
Status: ENROLLING_BY_INVITATION
Conditions: Acute Coronary Syndromes
Interventions: OTHER: self-management|OTHER: regular care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Extension Study of Patidegib Topical Gel, 2% in Subjects With Gorlin Syndrome (Basal Cell Nevus Syndrome)
Status: TERMINATED
Conditions: Basal Cell Nevus Syndrome
Interventions: DRUG: Patidegib Topical Gel, 2%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOLFIRINOX With Digoxin in Patients With Resectable Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreas Cancer|Adenocarcinoma of the Pancreas
Interventions: DRUG: Digoxin|DRUG: 5Fluorouracil|DRUG: Calcium Leucovorin|DRUG: Irinotecan|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Assessment of ALD403 in Frequent Episodic Migraine
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: DRUG: ALD403|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Gender-based Differences in the Outcome of Treatment With Aldosterone Antagonists in Patients With Heart Failure
Status: COMPLETED
Conditions: Heart Failure|Heart Failure With Reduced Ejection Fraction|Heart Failure NYHA Class II|Heart Failure NYHA Class III|Heart Failure NYHA Class IV
Interventions: DRUG: Potassium sparing diuretic
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Study of AeroVanc for the Treatment of Persistent MRSA Lung Infection in Cystic Fibrosis Patients
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Vancomycin hydrochloride inhalation powder|DRUG: Placebo inhalation powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Analgesic Technique on Post Operative Rehabilitation After Median Laparotomy
Status: RECRUITING
Conditions: Laparotomy
Interventions: DRUG: Epidural analgesia|DRUG: Bilateral rectus sheath block|PROCEDURE: Laparotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Biktarvy in Treatment-Naïve Late Presenters With HIV-1 Infection
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV-1-infection
Interventions: DRUG: B/F/TAF|DRUG: TDF/3TC/EFV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of AZD0486 Plus Rituximab in Previously Untreated Follicular Lymphoma Patients
Status: RECRUITING
Conditions: Untreated Follicular Lymphoma
Interventions: DRUG: AZD0486|DRUG: R-CHOP|DRUG: R-CVP|DRUG: BR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Growth Hormone Therapy on Metabolic Function in Fatty Liver Post-Pituitary Adenoma Surgery
Status: RECRUITING
Conditions: Growth Hormone Treatment
Interventions: DRUG: Polyethylene Glycol Somatropin (rDNA origin) Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Antibiotics in Admitted Cirrhotics
Status: COMPLETED
Conditions: Cirrhosis, Liver
Interventions: DRUG: Ceftriaxone|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Virtual Visit for Women With Gestational Diabetes
Status: COMPLETED
Conditions: Diabetes, Gestational
Interventions: DEVICE: 1-Self-monitoring of blood glucose|DEVICE: 2-Self-weighing|DEVICE: 3-Self-checking of blood pressure|DEVICE: 4-Checking fetal heart rate|PROCEDURE: 5-Visits with caregivers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Macular Changes After Intracameral Moxifloxacin for Prevention of Endophthalmitis
Status: COMPLETED
Conditions: Endophthalmitis|Macula Edema|Cataract
Interventions: DRUG: Moxifloxacin Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: REACH2: Implementation Research on Bi-Annual Mass Distribution of Azithromycin to Children 1-11 Months in Côte d'Ivoire
Status: RECRUITING
Conditions: Child Mortality
Interventions: DRUG: Single-dose azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Perioperative Pembrolizumab (MK-3475) Plus Cystectomy or Perioperative Pembrolizumab Plus Enfortumab Vedotin Plus Cystectomy Versus Cystectomy Alone in Participants Who Are Cisplatin-ineligible or Decline Cisplatin With Muscle-invasive Bladder Cancer (MK-3475-905/KEYNOTE-905/EV-303)
Status: ACTIVE_NOT_RECRUITING
Conditions: Urinary Bladder Cancer, Muscle-invasive
Interventions: DRUG: Pembrolizumab|PROCEDURE: Surgery (radical cystectomy (RC) plus Pelvic Lymph Node Dissection [PLND])|DRUG: Enfortumab Vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Paroxetine CR and Quetiapine for the Treatment of Refractory Generalized Anxiety Disorder
Status: COMPLETED
Conditions: Anxiety Disorder
Interventions: DRUG: Continued Paroxetine CR|DRUG: Quetiapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Complex EVAR in Inflammatory and Infective Abdominal and Thoracoabdominal Aortic Aneurysms
Status: ENROLLING_BY_INVITATION
Conditions: Inflammatory Abdominal Aortic Aneurysm|Aneurysm, Infected|Aneurysm, Mycotic|Abdominal Aortic Aneurysm|Thoracoabdominal Aortic Aneurysm
Interventions: PROCEDURE: Complex endovascular aortic repair (cEVAR)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Minimally Invasive Interval Debulking Surgery in Ovarian Neoplasm: a Feasibility Study
Status: COMPLETED
Conditions: Stage IV Ovarian Carcinoma|Effects of Chemotherapy|Peritoneal Cavity Cancer
Interventions: PROCEDURE: Laparoscopic interval debulking surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drainage or Pericardiocentesis (DROP) Alone for Recurrent Non-malignant Pericardial Effusions Requiring Intervention
Status: UNKNOWN
Conditions: Pericardial Effusion
Interventions: PROCEDURE: Extended pericardial drainage by catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Hyperbaric Oxygen Therapy for Comatose Patients With Acute Carbon Monoxide Poisoning
Status: TERMINATED
Conditions: Carbon Monoxide Poisoning
Interventions: OTHER: Hyperbaric oxygen therapy|OTHER: hyperbaric oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Persistent CMV-infection on Immune Senescence
Status: COMPLETED
Conditions: Immune Senescence
Interventions: BIOLOGICAL: Vaccination against TBEV (FSME Immun CC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Serum IGF-II and Cancer: Can IGF II Levels be Used to Monitor and Screen Patients Specifically for Cervical Cancer
Status: UNKNOWN
Conditions: Cervical Cancer|Cervical Intraepithelial Neoplasia II|Cervical Intraepithelial Neoplasia III
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of ABCB1,SLC22A16 Drug Transporter Genes and Doxorubicin and Cyclophosphamide Toxicity in Brest Cancer Patient
Status: UNKNOWN
Conditions: Breast Cancer Patients
Interventions: GENETIC: polymorphism analysis|DRUG: Doxorubicin-Cyclophosphamide regimen
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Sleep Program to Improve Sleep Quality in People With HIV
Status: TERMINATED
Conditions: HIV - Human Immunodeficiency Virus|Insomnia Disorder
Interventions: BEHAVIORAL: Digital cognitive behavioural therapy for insomnia (dCBT-I)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Maitland Oscillatory Mobilizations With Kaltenborn Sustained Stretch Mobilizations in Cervicogenic Headache Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervicogenic Headache
Interventions: PROCEDURE: Maitland Oscillatory Mobilization|PROCEDURE: Kaltenborn Sustained Stretch Mobilization|PROCEDURE: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Trial to Evaluate the EBA, Safety and Tolerability of Eto Alone and in Combination With BVL-GSK098
Status: RECRUITING
Conditions: Rifampicin- and Isoniazid-Susceptible Pulmonary Tuberculosis (TB)
Interventions: DRUG: BVL-GSK098 9mg|DRUG: Ethionamide 250mg|DRUG: Ethionamide 250 mg|DRUG: Isoniazid 300 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors
Status: RECRUITING
Conditions: Advanced Pancreatic Cancer|Advanced Solid Tumor
Interventions: DRUG: Metformin|DRUG: Simvastatin|DRUG: Digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Advanced Heart Care at Home
Status: ACTIVE_NOT_RECRUITING
Conditions: Palliative Care|Heart Failure|Health Care Utilization|Quality Improvement
Interventions: OTHER: Clinician nudge or opt out approach for AHCAH liaison visit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Pevonedistat and Venetoclax Combined With Azacitidine to Treat Acute Myeloid Leukemia (AML) in Adults Unable to Receive Intensive Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: Pevonedistat|DRUG: Venetoclax|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of XZP-3287 in Combination With Letrozole/Anastrozole in Patients With Advanced Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Advanced Breast Cancer
Interventions: DRUG: XZP-3287+ Letrozole/Anastrozole|DRUG: Placebo + Letrozole/Anastrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Rifaximin in Treatment of Cirrhotic Gastroesophageal Variceal Bleeding
Status: UNKNOWN
Conditions: Cirrhosis|Esophageal and Gastric Varices|Gastrointestinal Hemorrhage
Interventions: DRUG: Rifaximin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study to Evaluate the Immunogenicity and Safety of an Adjuvanted Quadrivalent Influenza Vaccine Compared With a Licensed Quadrivalent Vaccine in Adults 50 to 64 Years of Age
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: aQIV|BIOLOGICAL: Comparator QIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Artificial Intelligence in Colonic Polyp Detection
Status: COMPLETED
Conditions: Polyp of Colon|Adenoma Colon|Gastrointestinal Neoplasms
Interventions: DEVICE: Artificial intelligence|DEVICE: No Artificial Intelligence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial)
Status: RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Panitumumab|DRUG: Sotorasib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combining Saxagliptin and Acarbose to Improve Postprandial Glycaemia in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Saxagliptin|DRUG: Acarbose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Low-FODMAP Gluten-free Diet on Gut Microbiota and Circulating miRNAs in Celiac Disease Patients
Status: RECRUITING
Conditions: Celiac Disease
Interventions: DIETARY_SUPPLEMENT: Low FODMAPs /balanced gluten free diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing the Transition From Acute to Chronic Musculoskeletal Pain Among Older Adults
Status: COMPLETED
Conditions: Acute Musculoskeletal Pain|Chronic Pain
Interventions: BEHAVIORAL: Educational Video|BEHAVIORAL: Telecare|BEHAVIORAL: Correspondence with Primary Care Provider
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cumulative Irritation Test
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: AN2690|DRUG: AN2690|DRUG: AN2690|OTHER: AN2690 Solution, Vehicle|OTHER: Sodium Lauryl Sulfate, 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: OTHER
Clinical trial: Vitamin c Supplementation in the Prevention of CRPS Following Distal Radius Fractures
Status: RECRUITING
Conditions: Distal Radius Fracture|Vitamine c|Prophylaxis
Interventions: DRUG: Vitamin C|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optimizing Surgical and Prosthetic Workflow for Implant-supported Ear and Nose Prostheses With Early Loading and Distant Prosthesis Fabrication: A Prospective Cohort Study
Status: NOT_YET_RECRUITING
Conditions: Facial Deformity|Implant Complication
Interventions: DEVICE: Craniofacial implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coadministration of Ezetimibe and Atorvastatin in Patients With Primary Hypercholesterolemia (P05456)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Ezetimibe|DRUG: atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy of Oxybutynin Chloride in Patients With Primary Hyperhidrosis
Status: WITHDRAWN
Conditions: Hyperhidrosis
Interventions: DRUG: Oxybutynin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Video Assisted Informed Consent for Lortab to Improve Patient Satisfaction and Knowledge
Status: COMPLETED
Conditions: Non-critical Emergency Room Patients Receiving Lortab Medication or Prescription During Their Emergency Room Visit
Interventions: OTHER: video|OTHER: standard education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose:
Clinical trial: A Research Study to See if a Change in Therapy for HIV Infection Can Improve the Immune Response to Treatment
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Kaletra + Current Dual NRTI Backbone|DRUG: Current Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Development of a New Instrument to Evaluate Gait Characteristics of Individuals With Duchenne Muscular Dystrophy
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy|Gait Disorders in Children|Gait Disorders, Neurologic
Interventions: OTHER: Duchenne Muscular Dystrophy Gait Assessment Scale
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: VGX-3100 Delivered Intramuscularly (IM) Followed by Electroporation (EP) for the Treatment of HPV-16 and/or HPV-18 Related Anal or Anal/Peri-Anal, High Grade Squamous Intraepithelial Lesion (HSIL) in Individuals Seronegative for Human Immunodeficiency Virus (HIV)-1/2
Status: COMPLETED
Conditions: Anal Neoplasm
Interventions: BIOLOGICAL: VGX-3100|DEVICE: CELLECTRA™ 5PSP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temporal Diffusion Spectroscopy MRI in Predicting the CPS of PD-L1 Expression and the Efficacy of Neoadjuvant Therapy
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma|Magnetic Resonance Imaging|Neoadjuvant Therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: US-licensed Combined Vaccine Against Tetanus & Diphtheria, Given With US-licensed Vaccine Against Meningococcal Disease
Status: COMPLETED
Conditions: Acellular Pertussis|Tetanus|Diphtheria
Interventions: BIOLOGICAL: Boostrix®|BIOLOGICAL: Menactra™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Cisplatin and Irinotecan Chemotherapy, Followed by ZD 1839 (Iressa) in Patients With Esophageal or Gastric Carcinomas
Status: COMPLETED
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: DRUG: Cisplatin|DRUG: Irinotecan|DRUG: ZD 1839
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Asthma Self-management Via Application of Telehealth
Status: UNKNOWN
Conditions: Asthma|Mixed Asthma With Acute Exacerbation
Interventions: OTHER: electronic asthma action plan (eAAP)|OTHER: written asthma action plan (WAAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 2 Clinical Study to Investigate Effects of Darapladib in Subjects With Diabetic Macular Edema
Status: COMPLETED
Conditions: Retinopathy, Diabetic
Interventions: DRUG: darapladib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Can SMOFlipid®, A Composite Parenteral Nutrition Lipid Emulsion, Prevent Progression Of Parenteral Nutrition Associated Liver Disease In Infants?
Status: UNKNOWN
Conditions: Short Bowel Syndrome|Intestinal Failure|Gastrointestinal Motility Disorder|Mucosal Enteropathy
Interventions: DRUG: Intralipid 20%|DRUG: SMOFlipid 20%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Repeat Dose Tolerance Study of Regadenoson in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Regadenoson|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Preserving Beta-cell Function in Type 2 Diabetes With Exenatide and Insulin (PREVAIL)
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Basal insulin and exenatide|DRUG: Basal insulin only|DRUG: Basal insulin and bolus insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genomic and Psychosocial Effects of the 3RP on Patients With MGUS and Smoldering Multiple Myeloma
Status: COMPLETED
Conditions: Monoclonal Gammopathy of Undetermined Significance|Smoldering Multiple Myeloma
Interventions: BEHAVIORAL: Relaxation Response Resiliency Program (3RP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treating Pregnancy Related Insomnia With Music
Status: COMPLETED
Conditions: Pregnancy Related|Sleep Disturbance|Insomnia
Interventions: OTHER: Music|BEHAVIORAL: Sleep hygiene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Intraperitoneal Instillation of Lidocaine at Cesarean Delivery Improve Postoperative Analgesia?
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Lidocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cryotherapy Efficacy During Pulp Therapy of the Mandibular First Permanent Molars in Children
Status: UNKNOWN
Conditions: Cryotherapy Effect|Irreversible Pulpitis|Pain
Interventions: OTHER: Cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of E7389 Liposomal Formulation (E7389-LF) Plus Nivolumab in Participants With Solid Tumor
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Neoplasms
Interventions: DRUG: E7389-LF|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Valiant Mona LSA Stent Graft System
Status: COMPLETED
Conditions: Thoracic Aortic Aneurysms
Interventions: DEVICE: Valiant Mona LSA Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of INCMGA00012 in Squamous Carcinoma of the Anal Canal Following Platinum-Based Chemotherapy (POD1UM-202)
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of Anal Canal
Interventions: DRUG: Retifanlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Therapy Treatment on Children and Adolescents With Neurological Pathologies
Status: COMPLETED
Conditions: Neurologic Disorder|Duchenne|Pediatric Disorder|Sensorimotor Disorder Nos
Interventions: OTHER: Home-based physiotherapy|OTHER: Usual Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy and Chemotherapy in Unresectable Recurrent Loco-regionally Advanced Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Recurrent Nasopharyngeal Carcinoma|Unresectable Nasopharyngeal Carcinoma|Chemotherapy Effect|Immunotherapy|Stereotactic Body Radiation Therapy (SBRT)
Interventions: DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Limbic Self-modulation as a Potential Treatment for Patients Suffering From Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia (FM)
Interventions: DEVICE: Simultaneous EEG and fMRI recordings|DEVICE: Amygdala-Electrical Fingerprint (Amyg-EFP)-NF Trial|DEVICE: Amygdala-Electrical Fingerprint (Amyg-EFP)-NF Sham Trial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomised, Double-blind Study to Investigate the Safety and Efficacy of Brotizolam in Insomnia Outpatients.
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders
Interventions: DRUG: Brotizolam|DRUG: Estazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: An Extension Study of MOM-M281-004 to Evaluate the Safety, Tolerability, and Efficacy of M281 Administered to Patients With Generalized Myasthenia Gravis
Status: TERMINATED
Conditions: Generalized Myasthenia Gravis
Interventions: DRUG: M281
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sinonasal Microbiome Transplant as a Therapy for Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
Status: COMPLETED
Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: PROCEDURE: Microbiome transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Augmentation of EMDR With tDCS in the Treatment of Fibromyalgia
Status: ACTIVE_NOT_RECRUITING
Conditions: Fibromyalgia|Psychological Trauma|Depressive Symptoms|Anxiety
Interventions: BEHAVIORAL: Eye Movement Desensitization and Reprocessing therapy|OTHER: Multifocal transcranial Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: LEft VEntricuLar Activation Time Shortening With Physiological Pacing vs Biventricular Resynchronization Therapy
Status: COMPLETED
Conditions: Physiological Pacing|Resynchronization Therapy
Interventions: DEVICE: Lead placed in the His-Purkinje system in order to achieve QRS shortening.|DEVICE: Lead is placed in a tributary of the coronary sinus.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Latent Structure of Multi-level Assessments and Predictors of Outcomes for Women in Recovery
Status: ACTIVE_NOT_RECRUITING
Conditions: Depression|Anxiety|Eating Disorders|Drug Use Disorders|Stress Disorders, Post-Traumatic
Interventions: BEHAVIORAL: Women in a court diversion program
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile - Associated Diarrhea
Status: COMPLETED
Conditions: Clostridium Difficile Infection
Interventions: DRUG: Cadazolid|DRUG: Vancomycin|DRUG: Cadazolid-matching placebo|DRUG: Vancomycin-matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Links Between Cognitive Deficits During Normal or Pathological Aging and Slow Waves Measured in EEG
Status: NOT_YET_RECRUITING
Conditions: Aging|Alzheimer Disease
Interventions: OTHER: video polysomnography|OTHER: Attention task
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Audio-Recorded vs. Nurse-Led Brief Mindfulness-Based Intervention
Status: WITHDRAWN
Conditions: Pain|Osteoarthritis, Knee|Osteoarthritis, Hip
Interventions: BEHAVIORAL: Standard Pain Management|BEHAVIORAL: Audio-Recorded Mindfulness-Based Intervention|BEHAVIORAL: Nurse-Led Mindfulness-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Genetic Polymorphisms of ABCG2/BCRP on the Transport of Nifedipine to Breast Milk.
Status: UNKNOWN
Conditions: Drug Transporter
Interventions: PROCEDURE: Blood and breast milk sampling|DRUG: Nifedipine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Single-centre, Open-label Study to Confirm the Efficacy and Safety of Vitamin D3 B.O.N. Intramuscular Injection in Adults With Vitamin D Deficiency
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DRUG: Vitamin D3 B.O.N. Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of COVID-19 Vaccines on Cerebrovascular Health
Status: RECRUITING
Conditions: Stroke|Stroke, Acute|Stroke, Ischemic|Dementia|Brain Ischemia|Alzheimer Disease|Brain Diseases|Major Adverse Cardiovascular Event|Arterial Thromboembolism|Venous Thromboembolism
Interventions: DIAGNOSTIC_TEST: Laboratory tests and Montreal Cognitive Assessment|DIAGNOSTIC_TEST: Laboratory tests and Montreal Cognitive Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Akt/ERK Inhibitor ONC201 in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Central Nervous System Lymphoma|Gastric Mantle Cell Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Non-Hodgkin Lymphoma|Refractory Mantle Cell Lymphoma|Refractory Non-Hodgkin Lymphoma|Splenic Mantle Cell Lymphoma
Interventions: DRUG: Akt/ERK Inhibitor ONC201|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acellular Porcine Dermal Matrix Wound Dressing in the Management of Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot Ulcers
Interventions: DEVICE: APM Graft (BIOTAPE XMTM)|OTHER: Wound Debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [18 Fluorine(F)]DOPA Determinants and Predictors of Treatment Response in Psychosis
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DEVICE: PET scan|BEHAVIORAL: clinical scale|DRUG: 6 weeks of treatment with amisulpride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Surgical and Medical Treatment for Congestive Heart Failure and Coronary Artery Disease
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Disease|Heart Failure, Congestive|Heart Diseases
Interventions: PROCEDURE: CABG surgery plus MED|DRUG: Active Medication Alone|PROCEDURE: CABG plus MED and SVR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Dose-finding Study of Atacicept in Subjects With Rheumatoid Arthritis (AUGUST I)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Atacicept|DRUG: Atacicept|DRUG: Atacicept|DRUG: Placebo matched to atacicept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT