pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pea Protein Supplementation and Muscle Damage
Status: COMPLETED
Conditions: Muscular Injury
Interventions: DIETARY_SUPPLEMENT: NUTRALYS pea protein supplement|DIETARY_SUPPLEMENT: Whey Protein|DIETARY_SUPPLEMENT: Apple juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Helicobacter Pylori Eradication in Subjects With Non-alcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease
Interventions: DRUG: H.pylori eradication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adaptive Therapy of Vismodegib in Advanced Basal Cell Carcinoma
Status: RECRUITING
Conditions: Advanced Basal Cell Carcinoma
Interventions: DRUG: Vismodegib 150 MG Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Nitrofurantion Used as an Intracanal Medicament
Status: UNKNOWN
Conditions: Intracanal Medication
Interventions: DRUG: Nitrofurantoin capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Clinical Trial of Cryoimmunotherapy Against Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: Dendritic cell based cryoimmunotherapy|DRUG: Cyclophosphamide|DRUG: ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization of Transcutaneous Electrical Acustimulation (TEA) Modalities for Treatment of IBS-C
Status: COMPLETED
Conditions: IBS|Constipation
Interventions: DEVICE: Transcutaneous Electrical Acustimulation (TEA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Islet Transplantation in Type 1 Diabetic Kidney Transplant Recipients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type I
Interventions: BIOLOGICAL: Purified Pancreatic Islets|DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induced Motion Illusions Through Vision and Tendon Vibrations: Study of Interactions in Hemiplegic Subjects
Status: TERMINATED
Conditions: Hemiplegia
Interventions: DEVICE: Computerized Mirror Therapy (CMT)|DEVICE: Tendon vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety And Tolerability Of Subcutaneous MANP In Difficult To Control/Resistant Hypertensive Subjects
Status: COMPLETED
Conditions: Resistant Hypertension|Difficult to Control Hypertension
Interventions: DRUG: MANP|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of the VivaDiag ™ COVID-19 lgM / IgG Rapid Test in Early Detecting the Infection of COVID-19
Status: UNKNOWN
Conditions: Coronavirus Infections
Interventions: DEVICE: VivaDiag™ COVID-19 lgM/IgG Rapid Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Open-label Study of the Safety and Activity of Oprozomib in Patients With Hematologic Malignancies
Status: TERMINATED
Conditions: Multiple Myeloma|Waldenstrom Macroglobulinemia
Interventions: DRUG: oprozomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Little Flower Yoga for Kids: Evaluation of a Yoga and Mindfulness Program for Children With Increased Levels of Emotion Dysregulation and Inattention
Status: COMPLETED
Conditions: ADHD
Interventions: BEHAVIORAL: Little Flower Yoga For Kids
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of a Botanical Drug Containing East Indian Sandalwood Oil (EISO) for Treatment of Plaque Psoriasis in Adults
Status: WITHDRAWN
Conditions: Plaque Psoriasis
Interventions: DRUG: SAN021 Serum|DRUG: SAN021 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (LixiLan) to Insulin Glargine Alone on Top of Oral Anti-diabetic Drugs (OADs) With Type 2 Diabetes in Japan
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Insulin glargine/lixisenatide (HOE901/AVE0010)|DRUG: Insulin glargine (HOE901)|DRUG: Oral anti-diabetic drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DCLK1 as a Marker/Indicator of Stem Cell Response in Barrett's Esophagus/Esophageal Adenocarcinoma
Status: COMPLETED
Conditions: Barrett's Esophagus|Esophageal Adenocarcinoma
Interventions: OTHER: EMR and RFA effect on stem cell marker expression in BE/EAC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Platelet-rich Plasma vs. Hyaluronic Acid for Glenohumeral Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis|Shoulder Pain
Interventions: BIOLOGICAL: PRP|DRUG: Hyaluronic Acid|DEVICE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Single and Multiple Doses of Linagliptin Tablets in Patients With Different Degrees of Renal Impairment in Comparison to Subjects With Normal Renal Function
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: DRUG: Linagliptin - single dose|DRUG: Linagliptin - Multiple dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EUS-guided Choledochoduodenostomy vs ERCP as First Line in Malignant Distal Obstruction in Resectable Disease (CARPEDIEM-1 Trial)
Status: NOT_YET_RECRUITING
Conditions: Malignant Biliary Obstruction|Pancreatic Cancer Resectable|Biliary Tract Neoplasms
Interventions: PROCEDURE: Endoscopic biliary drainage|DEVICE: Self-expandable metallic stent (SEMS)|DEVICE: Lumen-apposing metal stent (LAMS) and double-pigtail plastic stent (DPPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ablation in Combination With Lenvatinib and Anti-PD-1 Antibodies
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: lenvatinib + anti-PD-1 antibodies|PROCEDURE: ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperproteic Diet Plus Lactobacillus Reuteri and Nitazoxanide in Minimal Hepatic Encephalopathy
Status: COMPLETED
Conditions: Hepatic Cirrhosis|Minimal Hepatic Encephalopathy
Interventions: OTHER: Auxiliary Treatment|DIETARY_SUPPLEMENT: Hyperproteic and fiber-rich diet|DRUG: Nitazoxanide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fetal Endoscopic Tracheal Occlusion (FETO) Trial for Congenital Diaphragmatic Hernia (CDH)
Status: RECRUITING
Conditions: Congenital Diaphragmatic Hernia
Interventions: DEVICE: FETO with Goldballoon Detachable Balloon (GOLDBAL2) along with the Delivery Microcatheter (BALTACCI-BDPE100)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deep Brain Stimulation for Treatment Resistant Depression
Status: RECRUITING
Conditions: Treatment Resistant Depression
Interventions: DEVICE: Active stimulation of the medial forebrain bundle or subcallosal cingulate|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Neoadjuvant Therapy Outcome Prediction of Muscle-invasive Bladder Cancer Based on PTC Drug Sensitivity Detection
Status: RECRUITING
Conditions: Muscle-Invasive Bladder Carcinoma
Interventions: DIAGNOSTIC_TEST: Patient-derived tumor-like cell clusters (PTC) drug sensitivity testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Short-term Efficacy and Long-term Prognosis for Reduction Surgery and Radical Resection in Almost-cCR Rectal Cancer Patients
Status: UNKNOWN
Conditions: Almost-cCR|Surgery|Rectal Cancer
Interventions: PROCEDURE: transanal surgery|PROCEDURE: Miles surgery|DRUG: Preoperative chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-Invasive Cardiometry and Ultrasound Guided Inferior Vena Cava Collapsibility Index in Assessing Fluid Responsiveness
Status: COMPLETED
Conditions: Volume Overload|Tissue Perfusion
Interventions: DEVICE: OSYPKA Medical ICONTM Noninvasive CardiometerTM Model C3|DEVICE: Fujifilm Sonosite M-Turbo C Ultrasound system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: STAND - Study of the AGN1 LOEP SV Kit Compared to PMMA in Patients with Vertebral Compression Fractures
Status: RECRUITING
Conditions: Vertebral Compression Fracture|Compression Fracture|Vertebral Compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Absorption and Digestion Kinetics of Human Metabolites
Status: COMPLETED
Conditions: Postprandial Inflammation
Interventions: DIETARY_SUPPLEMENT: Spermidine|DIETARY_SUPPLEMENT: Nicotinamide|DIETARY_SUPPLEMENT: PEA|DIETARY_SUPPLEMENT: OEA|DIETARY_SUPPLEMENT: Wheat Flour
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Nurse-led Case Management Based on Prevention and Control of Acute Myocardial Infarction
Status: UNKNOWN
Conditions: Acute Myocardial Infarction
Interventions: OTHER: Nurse -led case management|OTHER: Routine inpatient care and post-discharge follow-up management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Evaluation of Lithium Disilicate and Hybrid Nano-ceramic Anterior Endocrowns (Randomized Clinical Trial)
Status: COMPLETED
Conditions: Personal Satisfaction
Interventions: PROCEDURE: Endocrown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Calcium Plus Vitamin D Supplementation on Adolescent Mother and Infant Bone Health
Status: UNKNOWN
Conditions: Lactation Bone Loss|Infant Bone Growth
Interventions: DIETARY_SUPPLEMENT: Calcium plus vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Therapy With High Clopidogrel Dose or Prasugrel Standard Dose Reduces the Platelet Reactivity in Patients With Genotype Variation RESET GENE Trial
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Clopidogrel|DRUG: prasugrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective, Single Center Switching Study of 0.0015% Tafluprost Ophthalmic Solution in Primary Open-angle Glaucoma and Ocular Hypertension Patients With Corneal Disorders (Switching From 0.005% Latanoprost Ophthalmic Solution)
Status: COMPLETED
Conditions: Glaucoma, Primary Open Angle
Interventions: DRUG: Latanoprost|DRUG: tafluprost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Recurrent Urinary Tract Infection (RUTI) by Traditional Chinese Medicine
Status: UNKNOWN
Conditions: Recurrent Urinary Tract Infection
Interventions: DRUG: LVX-AMX|DRUG: TCM|DRUG: LVX-AMX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of Two Different Approaches to Radiofrequency Ablation of Lumbar Medial Branch Nerves
Status: NOT_YET_RECRUITING
Conditions: Lumbar Spondylosis
Interventions: PROCEDURE: Radiofrequency ablation of lumbar medial branch nerves.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of HQ® Matrix Soft Tissue Mesh for the Treatment of Inguinal Hernia
Status: UNKNOWN
Conditions: Inguinal Hernia
Interventions: DEVICE: HQ® Matrix Soft Tissue Mesh|DEVICE: ULTRAPRO® Partially Absorbable Lightweight Mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Tongxinluo Capsule in Preventing and Treating Restenosis After Intracranial and External Arterial Stenting
Status: NOT_YET_RECRUITING
Conditions: Stent Restenosis
Interventions: DRUG: Tongxinluo capsule|OTHER: Primary therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation, Multi-arm Study of MLN4924 Plus Docetaxel, Gemcitabine, or Combination of Carboplatin and Paclitaxel in Participants With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: MLN4924|DRUG: Paclitaxel|DRUG: Gemcitabine|DRUG: Docetaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Lactobacillus Reuteri ProGastria in Helicobacter Pylori-infected Adult Subjects on Proton Pump Inhibitors
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DIETARY_SUPPLEMENT: Progastria|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Thoracoscopic Talc Pleurodesis by Thoracic Epidural or General Anesthesia
Status: COMPLETED
Conditions: Pleural Effusion
Interventions: PROCEDURE: Non-awake VATS talc pleurodesis|PROCEDURE: Awake VATS talc pleurodesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Delivery Format of Cognitive Behavioral Therapy Materials on Engagement and Outcomes: AI-Enabled App vs PDF Workbook
Status: ACTIVE_NOT_RECRUITING
Conditions: Mental Health Issue
Interventions: DEVICE: Limbic Care|DEVICE: Digital Workbook
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Perception of Dental Local Anesthesia Using "DentalVibe Comfort System" in a Group of Egyptian Children
Status: UNKNOWN
Conditions: Dental Anxiety
Interventions: DEVICE: injection using DentalVibe comfort system|DEVICE: traditional dental injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Promotion Plan of Moxibustion on Ulcerate Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: OTHER: Herb-partitioned moxibustion|OTHER: Sham herb-partitioned moxibustion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Stereotactic Radiosurgery Combination With Anlotinib for Limited Brain Metastases With Perilesional Edema in NSCLC
Status: UNKNOWN
Conditions: Stereotactic Body Radiation Therapy
Interventions: DRUG: Anlotinib|RADIATION: Stereotactic Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Antiviral Local Application to Treat High Grade Cervical Intraepithelial Lesions (CIN2/3)
Status: COMPLETED
Conditions: Uterine Cervical Neoplasia|Cervix Intraepithelial Neoplasia
Interventions: DRUG: C1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dance4Healing: Explore the Benefits of Tele-Dance in Individuals With an Implantable Cardioverter-defibrillator (ICD)
Status: WITHDRAWN
Conditions: ICD|Anxiety|Patient Engagement
Interventions: BEHAVIORAL: Dance4Healing Telehealth Live Zoom Sessions|BEHAVIORAL: Dance Buddy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Airway Clearance Study
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Budesonide/Formoterol Turbuhaler|DRUG: Salmeterol/Fluticasone Diskus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Budesonide (Pulmicort®) Turbuhaler® in Japanese Children With Bronchial Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Budesonide|DRUG: Conventional Asthma Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Whole-body Vibration on Increasing Quadriceps Strength in Patients With ACL Ruptures
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Injuries|Quadriceps Muscle Atrophy
Interventions: DEVICE: Whole body vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2A Open Label Safety Study of Fovista® (Anti-PDGF BB) Regimen Administered in Combination With Anti-VEGF Therapy to Study Sub-Retinal Fibrosis in Neovascular AMD
Status: TERMINATED
Conditions: Age-related Macular Degeneration
Interventions: DRUG: Fovista® (anti-PDGF BB) plus anti-VEGF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FUDR/Oxaliplatin HAI Plus Irinotecan vs. FOLFOXIRI Chemotherapy in Treating Initially Unresectable CRCLM
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer|Liver Metastases
Interventions: DRUG: Irinotecan|DRUG: Oxaliplatin HAI|DRUG: Floxuridine|DRUG: Leucovorin|DRUG: 5-FU|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of INV-102 Ophthalmic Solution in Adults With Acute Infectious Keratoconjunctivitis
Status: RECRUITING
Conditions: Acute Infectious Keratoconjunctivitis
Interventions: DRUG: INV-102|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Assess the Safety and Activity of GBR 830, Compared to Placebo, in Adults With Moderate-to-severe Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: GBR 830|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cannabidiol Effects on Craving and Relapse Prevention in Opioid Use Disorder
Status: COMPLETED
Conditions: Opioid-use Disorder
Interventions: DRUG: Cannabidiol (CBD) 600 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Response of Recombinant Antithrombin in Heparin Resistant Patients Undergoing Cardiac Surgery
Status: TERMINATED
Conditions: Thrombophilia Due to Acquired Antithrombin III Deficiency
Interventions: DRUG: Recombinant antithrombin (rhAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dual Trigger to Reduce Ovarian Hyperstimulation Syndrome
Status: UNKNOWN
Conditions: Infertility and at High Risk of OHSS
Interventions: DRUG: triptorelin|DRUG: hCG|DRUG: hCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of RTH258 Versus Aflibercept - Study 2
Status: COMPLETED
Conditions: Neovascular Age-Related Macular Degeneration|Choroidal Neovascularization
Interventions: DRUG: Brolucizumab ophthalmic solution|DRUG: Aflibercept ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Intermittent Pneumatic Compression Device for Symptomatic Relief in Patients With Post Thrombotic Syndrome
Status: UNKNOWN
Conditions: Post Thrombotic Syndrome
Interventions: DEVICE: ActiveCare+S.F.T 3rd generation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of Patient Controlled Analgesia Using the Sublingual Sufentanil Tablet System (SSTS) in a Fast Track Rehabilitation Program After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Sufentanil Sublingual Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing the Polyurethane Films and Sugarcane Biopolymer Used as Dressings
Status: COMPLETED
Conditions: Wound|Rupture|Surgery|Cesarean Section
Interventions: DEVICE: Application of dressings for surgical correction.|DEVICE: POLYSHAFT®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential Vaccinations in Prostate Cancer Patients
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: Recombinant Fowlpox-GM-CSF|DRUG: Recombinant Fowlpox-PSA (L155)-TRICOM (PROSTVAC-F/TRICOM)|DRUG: Recombinant Vaccinia-PSA (L155)-TRICOM (PROSTVAC-V/TRICOM)|DRUG: Recombinant Human GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Drug Interaction Study Between BI 201335 and BI 207127 in Chronic Hepatitis C Infected Patients
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: midazolam|DRUG: BI 201335|DRUG: tenofovir|DRUG: caffeine|DRUG: tolbutamide|DRUG: tolbutamide|DRUG: midazolam|DRUG: caffeine|DRUG: pegylated interferon|DRUG: BI 201335|DRUG: BI 201335|DRUG: BI 207127|DRUG: BI 207127|DRUG: BI 201335|DRUG: BI 207127|DRUG: ribavirin|DRUG: ribavirin|DRUG: ribavirin|DRUG: pegylated interferon|DRUG: ribavirin|DRUG: caffeine|DRUG: tolbutamide|DRUG: BI 207127|DRUG: midazolam|DRUG: BI 201335|DRUG: BI 207127|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dry Needling for Myofascial Pain Syndrome
Status: COMPLETED
Conditions: Myofascial Pain Syndromes|Neck Pain
Interventions: OTHER: Group 1: Peppering|OTHER: group 2: spin and wait|OTHER: group 3: Peppering and spin and wait
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Study to Evaluate the Safety and Efficacy of Copanlisib in Combination With Nivolumab in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer (NSCLC)|Head and Neck Squamous Cell Carcinoma (HNSCC)|Hepatocellular Carcinoma (HCC)
Interventions: DRUG: Copanlisib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Popliteal Sciatic Nerve Block: Intraneural or Extraneural?
Status: COMPLETED
Conditions: Hallux Valgus
Interventions: PROCEDURE: Intraneural injection|PROCEDURE: Extraneural injection|DRUG: Ropivacaine|DEVICE: PAJUNK SonoPlex 22G needle.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Electrical Nerve Stimulation in Chemotherapy Induced Peripheral Neuropathy in Patients With Stage I-III Early Stage Breast Cancer
Status: RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Chemotherapy-Induced Peripheral Neuropathy|Early Stage Breast Carcinoma|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8
Interventions: OTHER: Transcutaneous Electrical Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Efect of Azithromicyn on Bronchopulmonary Displasia in Extremely Preterm and Very Preterm Infant
Status: COMPLETED
Conditions: Bronchopulmonary Dysplasia|Intraventricular Hemorrhage|Necrotizing Enterocolitis
Interventions: DRUG: Azithromycin Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluate Safety, Tolerability, PK, Preliminary Clinical Activity of OB318 in Patients With Advanced Solid Malignancies
Status: RECRUITING
Conditions: Advanced Solid Malignancies
Interventions: DRUG: OB318 capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine and Cisplatin as Neoadjuvant Chemotherapy in Patients With High-Grade Upper Tract Urothelial Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Urothelial Carcinoma
Interventions: DRUG: Gemcitabine and Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Establishing the Effect of Flavor on the Addictive Potential of Electronic Cigarettes
Status: COMPLETED
Conditions: Tobacco Dependence
Interventions: OTHER: Nicotine Containing ECIG with tobacco flavor|OTHER: Nicotine Containing ECIG with Strawberry Vanilla Flavor|OTHER: Placebo ECIG with Tobacco Flavor|OTHER: Placebo ECIG with Strawberry Vanilla Flavor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Single vs. Multiple Fraction Trial of Stereotactic Ablative Radiotherapy for Comprehensive Treatment of Oligometastases/Progression
Status: NOT_YET_RECRUITING
Conditions: Oligometastatic Disease|Oligoprogression|Toxicity Due to Radiotherapy|Quality of Life
Interventions: RADIATION: Single fraction SABR|RADIATION: Multiple fraction SABR|OTHER: QoL reporting alone|OTHER: QoL reporting, symptom screen and healthcare provider intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Mydriasis by Mydrane With Topical Drop Application
Status: COMPLETED
Conditions: Cataract
Interventions: DRUG: Eye injection (Mydrane)|DRUG: eye drops (Phenylephrin)|DRUG: eye drops (Tropicamid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Imaging Features for the Risks for Recurrence After Stereotactic Radiosurgery in Brain Metastasis
Status: RECRUITING
Conditions: Brain Metastases|Radiosurgery
Interventions: DIAGNOSTIC_TEST: Magnetic resonance imaging (MRI)|DIAGNOSTIC_TEST: Diffusion-weighted MRI|DIAGNOSTIC_TEST: Arterial spin labeling (ASL)|DIAGNOSTIC_TEST: Dynamic susceptibility contrast-MRI (DSC-MRI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Examine the Effect of Food on the Pharmacokinetics of the Fixed Dose Combination of COREG CR and Lisinopril.
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: COREG CR and lisinopril (FDC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Response Evaluation in Oligorecurrent and Oligoprogressive Prostate Cancer Patients Treated With SBRT
Status: RECRUITING
Conditions: Oligorecurrent and Oligoprogressive Prostate Cancer Patients
Interventions: PROCEDURE: Radiotherapy|DRUG: androgen deprivation therapy (ADT)|BIOLOGICAL: immune evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Donor Umbilical Cord Blood Transplant in Treating Patients With Hematologic Cancer
Status: TERMINATED
Conditions: Chronic Myeloproliferative Disorders|Diamond-blackfan Anemia|Fanconi Anemia|Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases
Interventions: DRUG: anti-thymocyte globulin|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: filgrastim|DRUG: melphalan|DRUG: methylprednisolone|DRUG: mycophenolate mofetil|PROCEDURE: radiation therapy|PROCEDURE: umbilical cord blood transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Ceftazidime / Avibactam Treatment vs Better Available Therapy on Mortality of Patients With Infections Caused by Carbapenem-resistant Enterobacteria
Status: COMPLETED
Conditions: Carbapenem-Resistant Enterobacteriaceae Infection
Interventions: DRUG: Ceftazidime-Avibactam|DRUG: Best Available Therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: EU PV for Retapamulin-Prescribing
Status: COMPLETED
Conditions: Impetigo
Interventions: DRUG: Retapamulin|DRUG: Co-prescription of retapamulin and topical mupirocin|DRUG: Co-prescription of retapamulin and topical fusidic acid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Glucagon Like Peptide-1 on No-reflow
Status: UNKNOWN
Conditions: Acute ST-segment Elevation Myocardial Infarction
Interventions: DRUG: liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Cyanoacrylate Tissue Adhesive and Suture for Closure of Cardiac Device Pockets
Status: TERMINATED
Conditions: Cardiovascular Disease
Interventions: DEVICE: Cyanoacrylate tissue adhesive (Dermabond)|DEVICE: Polyglactin 910 suture (Vicryl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mag Con: Efficacy of Oral Mag. in Acute Concussion in Adolescents
Status: WITHDRAWN
Conditions: Concussion, Mild|Traumatic Brain Injury, Mild
Interventions: DIETARY_SUPPLEMENT: Magnesium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dacarbazine and Recombinant Interferon Alfa-2b in Treating Patients With Primary Uveal Melanoma With Genetic Imbalance
Status: COMPLETED
Conditions: Ciliary Body and Choroid Melanoma, Medium/Large Size|Ciliary Body and Choroid Melanoma, Small Size|Iris Melanoma|Recurrent Intraocular Melanoma
Interventions: BIOLOGICAL: recombinant interferon alfa-2b|DRUG: dacarbazine|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vorinostat Dose-escalation After Allogeneic Hematopoietic Cell Transplantation
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes|Mixed Phenotype Acute Leukemia|Juvenile Myelomonocytic Leukemia
Interventions: DRUG: Vorinostat|DRUG: Azacitidine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Lung Deposition of Radiolabelled OligoG
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Radiolabelled OligoG CF-5/20 DPI|DRUG: Radiolabelled OligoG CF-5/20 6% Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Probiotics to Prevent Relapse After Hospitalization for Bipolar Depression
Status: ENROLLING_BY_INVITATION
Conditions: Bipolar Depression
Interventions: BIOLOGICAL: Probiotic Supplement|BIOLOGICAL: Inert Compound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phytosterols and Oxyphytosterol Concentrations
Status: COMPLETED
Conditions: Normocholesterolemic
Interventions: DIETARY_SUPPLEMENT: Plant sterol-enriched margarine|DIETARY_SUPPLEMENT: Plant stanol-enriched margarine|DIETARY_SUPPLEMENT: Control margarine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Training Programs to Improve Outcomes for Individuals With Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: OTHER: Group 1 Training Program|OTHER: Group 2 Training Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Paracervical Block in Endometrial Sampling Procedures for Pain Control
Status: COMPLETED
Conditions: Office-based Endometrial Sampling Procedures
Interventions: PROCEDURE: Paracervical Block|DRUG: 550 mg Naproxen Sodium 60 minutes before the procedure|PROCEDURE: The capped needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Different Sedation Regimes on Cognitive Function in Lower Gastrointestinal System Endoscopy
Status: COMPLETED
Conditions: Gastrointestinal Dysfunction|Alteration of Cognitive Function
Interventions: DRUG: Midazolam|DRUG: Meperidine|DRUG: Remifentanil|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Is Cefazolin, Ceftazidime and Ciprofloxacin Dosing Optimal in Hemodialysis Patients?
Status: COMPLETED
Conditions: Hemodialysis Complication|Infectious Disease|End Stage Renal Disease
Interventions: DRUG: Cefazolin|DRUG: Ceftazidime
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability and Fat Absorption Using Enteral Feeding In-line Enzyme Cartridge (Relizorb)
Status: COMPLETED
Conditions: Exocrine Pancreatic Insufficiency
Interventions: DEVICE: RELiZORB|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of NiTi Laparoscopic Compression Anastomosis Clip (LapCAC) Device for Intra-Corporeal Lap-Colectomy
Status: UNKNOWN
Conditions: Colon Cancer
Interventions: DEVICE: LapCAC Laparoscopic Compression Anastomosis Clip
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Total Antioxidant Capacity Products Added to Diet
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Alixir - Pomegranate, apple and Açai drink / Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Telemedicine Notifications With Machine Learning for Postoperative Care
Status: NOT_YET_RECRUITING
Conditions: Surgery--Complications|Perioperative/Postoperative Complications|Acute Kidney Injury|Hospital Mortality
Interventions: DEVICE: Anesthesia Control Tower Notification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Adoptive Cell Therapy Plus Chemotherapy and Radiation After Surgery in Treating Patients With Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer|Neoplasms|Intestinal Neoplasms|Digestive System Neoplasms|Gastrointestinal Diseases
Interventions: BIOLOGICAL: DC-CIK|RADIATION: Radiotherapy|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Afatinib (BIBW2992) in HER2 (Human Epidermal Growth Factor Receptor 2)-Overexpressing Inflammatory Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Afatinib once daily (OD)|DRUG: Vinorelbine Weekly
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intralesional Versus Intramuscular Methotrexate for Non-melanoma Skin Cancers
Status: COMPLETED
Conditions: Non-melanoma Skin Cancers
Interventions: DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Cannabidiol for Bilateral Total Knee Arthroplasty
Status: RECRUITING
Conditions: Pain, Postoperative|Opioid Use|Knee Osteoarthritis
Interventions: DRUG: cannabidiol|OTHER: Ora-sweet SF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Describe the Safety, Tolerability, Immunogenicity, and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Individuals
Status: COMPLETED
Conditions: SARS-CoV-2 Infection|COVID-19
Interventions: BIOLOGICAL: BNT162b1|BIOLOGICAL: BNT162b2|OTHER: Placebo|BIOLOGICAL: BNT162b2SA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Postpartum Depression: Transdermal Estradiol Versus Sertraline
Status: TERMINATED
Conditions: Postpartum Depression
Interventions: DRUG: Transdermal Estradiol|DRUG: Sertraline|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OPTmizing Advanced Stage HodgkIn LymphoMa patIentS Therapy
Status: UNKNOWN
Conditions: Classical Hodgkin Lymphoma|Hodgkin Lymphoma (Category)|Hodgkin Disease|Hodgkin Lymphoma
Interventions: DRUG: Adriamycin|DRUG: Cyclophosphamide|DRUG: Vinblastine|DRUG: Dacarbazine|DRUG: Brentuximab Vedotin|DRUG: ABVD
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient Outcomes Evaluation of the EBI Vuelock™ Anterior Cervical Plate System
Status: COMPLETED
Conditions: Trauma|Tumor|Pseudarthrosis|Scoliosis|Degenerative Disc Disease
Interventions: DEVICE: VueLock™ Anterior Cervical Plate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Non-Metastatic Hepatocellular Carcinoma in Humans by Increasing Gabaergic Activity: A Pilot Study
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Baclofen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Assess the Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With PLD
Status: ACTIVE_NOT_RECRUITING
Conditions: Polycystic Liver Disease
Interventions: DRUG: CAM2029|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Measurement of Forces Applied Using a Macintosh Direct Laryngoscope Compared to GlideScope Video Laryngoscope
Status: COMPLETED
Conditions: Endotracheal Intubation|Laryngoscopy
Interventions: DEVICE: Macintosh (direct vision) laryngoscope|DEVICE: GlideScope videolaryngoscope (indirect vision)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Power of Touch. Non-Invasive C-Tactile Stimulation for Chronic Osteoarthritis Pain
Status: RECRUITING
Conditions: Chronic Pain
Interventions: DEVICE: Interoceptive stimulation treatment with mechanical stimulation of C-LTMRs afferences|DEVICE: Sham treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of MK-4482 for Prevention of Coronavirus Disease 2019 (COVID-19) in Adults (MK-4482-013)
Status: COMPLETED
Conditions: Coronavirus Disease (COVID-19)
Interventions: DRUG: Molnupiravir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial of NanoPac Focal Therapy for Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer|Prostate Adenocarcinoma|Prostate Cancer Adenocarcinoma|Prostatic Neoplasm|Urogenital Neoplasms|Genital Neoplasms, Male|Localized Cancer
Interventions: DRUG: NanoPac (sterile nanoparticulate paclitaxel) Powder for Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allopregnanolone for the Treatment of Traumatic Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury|Posttraumatic Epilepsy
Interventions: DRUG: Allopregnanolone injection|DRUG: Placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab Versus Lapatinib as Neoadjuvant Treatment for Her2+ Patients
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: Docetaxel|DRUG: Lapatinib|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Interaction Study of Dapoxetine 30mg and Mirodenafil 50mg
Status: COMPLETED
Conditions: Drug Interaction Potentiation
Interventions: DRUG: Dapoxetine 30mg tablet|DRUG: Mirodenafil 50mg tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Radiosurgery in Treating Patients With Spinal Metastases
Status: COMPLETED
Conditions: Metastatic Cancer
Interventions: OTHER: questionnaire administration|PROCEDURE: diffusion tensor imaging|PROCEDURE: functional magnetic resonance imaging|RADIATION: hypo-fractionated SRS|RADIATION: single-fraction SRS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Design and Usability Testing of a Tailored Intervention About Sleep and Sleep Disorders Among Transportation Workers
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: BEHAVIORAL: Personalized OSA messages|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety of LAIV4 in Children With Asthma
Status: COMPLETED
Conditions: Asthma in Children|Vaccine Adverse Reaction|Vaccine Reaction|Asthma|Wheezing|Influenza
Interventions: BIOLOGICAL: Live Attenuated Influenza Vaccine (LAIV)|BIOLOGICAL: Inactivated Influenza Vaccine (IIV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of the Chromium Nicotinate on Type 2 Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Chromium nicotinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Postural Tachycardia Syndrome|Postural Orthostatic Tachycardia Syndrome
Interventions: DEVICE: Inspiratory Threshold Device (Res-Q-Gard ITD)|DEVICE: Sham Inspiratory Threshold Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE