pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase 3 Pivotal Trial of NanoFlu™ in Older Adults
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: NanoFlu|BIOLOGICAL: Fluzone Quadrivalent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Special Drug Use Surveillance of Vonoprazan for "Prevention of Recurrence of Gastric/Duodenal Ulcer in Patients Receiving Low-dose Aspirin: Long-term Use"
Status: COMPLETED
Conditions: Gastric or Duodenal Ulcers
Interventions: DRUG: Vonoprazan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: On-pump Beating Coronary Artery Bypass Grafting by Ventricular Assist
Status: UNKNOWN
Conditions: Coronary Artery Bypass
Interventions: DEVICE: left ventricular assist|PROCEDURE: Biventricular assist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D for the Prevention of Diabetes Type 2
Status: COMPLETED
Conditions: Impaired Glucose Tolerance
Interventions: DRUG: cholecalciferol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Travoprost/Brinzolamide Fixed Combination Versus Travatan and Versus AZOPT
Status: TERMINATED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: Travoprost/Brinzolamide fixed combination|DRUG: Azopt|DRUG: Travatan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Muscle Block Versus Caudal Block by Sonar in Pediatrics Undergoing Lower Abdominal Surgery
Status: COMPLETED
Conditions: Postoperative Analgesia
Interventions: PROCEDURE: erector spinae block - caudal block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effects of Home Rehabilitation of Balance Based on Functional Exercises in People With Parkinson's Disease
Status: ENROLLING_BY_INVITATION
Conditions: Parkinson Disease
Interventions: OTHER: Home functional balance physiotherapy|OTHER: Conventional physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety After Multiple Doses of TNP-2198 Capsules, Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules in Helicobacter Pylori Infected-positive Participants
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: TNP-2198|DRUG: Rabeprazole Sodium|DRUG: Amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Hexakapron Reduces Bleeding in Bariatric Surgery
Status: TERMINATED
Conditions: Intra-Operative Injury - Other|Post Operative Hemorrhage|Tranexamic Acid
Interventions: DRUG: tranexamic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trying to Find the Correct Length of Treatment With Immune Checkpoint Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Bladder Urothelial Carcinoma|Locally Advanced Renal Pelvis Urothelial Carcinoma|Locally Advanced Ureter Urothelial Carcinoma|Locally Advanced Urethral Urothelial Carcinoma|Locally Advanced Urothelial Carcinoma|Metastatic Bladder Urothelial Carcinoma|Metastatic Renal Pelvis Urothelial Carcinoma|Metastatic Ureter Urothelial Carcinoma|Metastatic Urethral Urothelial Carcinoma|Metastatic Urothelial Carcinoma
Interventions: DRUG: Pembrolizumab|DRUG: Nivolumab|DRUG: Atezolizumab|DRUG: Durvalumab|DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home-based Mobile Guided Exercise-based Cardiac Rehabilitation Among Patients Undergoing TAVR
Status: NOT_YET_RECRUITING
Conditions: Cardiac Rehabilitation
Interventions: BEHAVIORAL: Home-based mobile guided exercise-based cardiac rehabilitation|BEHAVIORAL: Routine Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Change From Baseline to Chronic Kidney Disease Patient Before and After Administration Drug
Status: COMPLETED
Conditions: Chronic Renal Failure
Interventions: DRUG: Placebo|DRUG: HD-003 (800mg/day)|DRUG: HD-003 (1600mg/day)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects With Persistent Atrial Fibrillation
Status: ACTIVE_NOT_RECRUITING
Conditions: Persistent Atrial Fibrillation
Interventions: DEVICE: Phase 1: FARAPULSE Ablation System|DEVICE: Phase 2: FARAPULSE Ablation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic Effect on Dietary Nitrate to Plasma Nitrite Production ( OPEDNPN )
Status: RECRUITING
Conditions: Hypertension|Cardiovascular Diseases|Diabetes
Interventions: DIETARY_SUPPLEMENT: Herbiotics Oral + Ent Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Clinical Impact of Different Telemedicine Practices in Intensive Care Units
Status: NOT_YET_RECRUITING
Conditions: Telemedicine|Critical Care|Intensive Care Units
Interventions: OTHER: Intervention period
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Immunogenicity and Tolerability Study of Fluval AB Novo Suspension for Injection for Children and Adolescents
Status: COMPLETED
Conditions: Human Influenza
Interventions: BIOLOGICAL: Vaccination with Fluval AB Novo suspension for injection, half dose of a single intramuscular dose (0.25 ml)|BIOLOGICAL: Vaccination with Fluval AB Novo suspension for injection, single intramuscular dose (0.5 ml)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Temozolomide, Thalidomide, and Celecoxib Following Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: celecoxib|DRUG: temozolomide|DRUG: thalidomide|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Follow-up on Children and Adolescents With Type 1 Diabetes Treated With Insulin Detemir. An Extension to Trial NN304-1689
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin detemir|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery
Status: RECRUITING
Conditions: Brain Metastases|Brain Metastases, Adult|Brain Cancer
Interventions: DRUG: 18F fluciclovine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of the Combination of Erlotinib and Pertuzumab in Patients With Relapsed Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Pertuzumab|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early (4 Days) Versus Standard Drainage of the Abdominal Cavity After Pancreaticoduodenectomy
Status: COMPLETED
Conditions: Pancreatic Disease|Pancreatic Neoplasms
Interventions: PROCEDURE: Drain removal at D4|PROCEDURE: Standard drain removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Observation on Kuntai Capsule in Treating Early-onset Ovarian Hypofunction
Status: UNKNOWN
Conditions: Primary Ovarian Insufficiency
Interventions: DRUG: Kuntai Capsule|DRUG: Femoston
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of a Multicomponent Physical Therapy Program in Mechanically Ventilated Patient With Sepsis
Status: UNKNOWN
Conditions: Sepsis
Interventions: OTHER: Early multicomponent physical therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose Escalation Study of Clofarabine in Patients With Relapsed or Refractory Low Grade or Intermediate-Grade B-Cell Lymphoma
Status: COMPLETED
Conditions: B-Cell Lymphoma
Interventions: DRUG: Clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Navitoclax, Venetoclax and Decitabine for Advanced Myeloid Neoplasms
Status: ACTIVE_NOT_RECRUITING
Conditions: Myeloid Malignancy|Myelodysplastic Syndromes|Myelofibrosis|Acute Myeloid Leukemia|Myeloproliferative Neoplasm
Interventions: DRUG: Navitoclax|DRUG: Venetoclax|DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Approaches of Quadratus Lumborum Block for Post-operative Analgesia in Radical Cystectomy
Status: RECRUITING
Conditions: Quadratus Lumborum Block
Interventions: PROCEDURE: US guided injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ribociclib + PDR001 in Breast Cancer and Ovarian Cancer
Status: TERMINATED
Conditions: Metastatic Hormone-Receptor-Positive (HR+) Breast Cancer|HER2-Negative Breast Cancer|Metastatic Epithelial Ovarian Cancer
Interventions: DRUG: Ribociclib|DRUG: PDR001|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Inodilators Postsurgery in Neonates
Status: COMPLETED
Conditions: Low Cardiac Output Syndrome
Interventions: DRUG: Milrinone|DRUG: Levosimendan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gender Differences in Renal Functioning and Disease
Status: COMPLETED
Conditions: Chronic Renal Failure|Healthy Controls
Interventions: DIETARY_SUPPLEMENT: high-salt diet (V1) and low salt diet (V2)|DIAGNOSTIC_TEST: Contrast-enhanced ultrasound (CEUS)|DIAGNOSTIC_TEST: functional MRI|OTHER: Pilocarpine test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Epacadostat in Combination With Pembrolizumab and Azacitidine in Subjects With Metastatic Colorectal Cancer
Status: WITHDRAWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Epacadostat (INCB024360) in Combination with Pembrolizumab (MK-3475) and Azacitidine (VIDAZA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Prognostic Value of the Coagulolytic Balance Dependent on Circulating Microvesicles in the Occurrence of Thrombotic Events After Total Knee Replacement in Orthopedic Surgery.
Status: NOT_YET_RECRUITING
Conditions: Knee Prosthesis
Interventions: OTHER: Thrombotic risk assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Orally Administered AG-120 in Subjects With Advanced Solid Tumors, Including Glioma, With an IDH1 Mutation
Status: COMPLETED
Conditions: Cholangiocarcinoma|Chondrosarcoma|Glioma|Other Advanced Solid Tumors
Interventions: DRUG: AG-120
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: THRIVE Use in Pediatric Populations- Multi Site
Status: ENROLLING_BY_INVITATION
Conditions: Oxygen Deficiency|Desaturation of Blood|Hypoventilation|Anesthesia; Adverse Effect
Interventions: DEVICE: Transnasal Humidified Rapid-Insufflation Ventilatory Echange
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Graft Inflow Modulation for Portal Hyper-perfusion in Live Donor Liver Transplantation
Status: COMPLETED
Conditions: Cirrhosis, Liver
Interventions: PROCEDURE: Splenic artery ligation|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Gonyautoxins Local Periarticular Injection for Pain Management After Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Knee Arthroplasty|Pain Management
Interventions: DRUG: Gonyautoxins|DRUG: Chirocaine ketorolac epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Evaluation of the Next Generation Diagnostic Instrument (NGDI)
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Next Generation Diagnostic Instrument (NGDI)|DEVICE: Zyoptix Diagnostic Workstation (ZDW)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Soft Tissue Outcomes Of Badly Broken-Down Teeth Treated With Orthodontic Extrusion Compared With Immediate Implant Placement
Status: UNKNOWN
Conditions: Broken Teeth
Interventions: PROCEDURE: Orthodontic extrusion|PROCEDURE: Immediate implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Individualized Fortification of Breast Milk
Status: UNKNOWN
Conditions: Postnatal Growth Disorder|Neurodevelopment
Interventions: DIETARY_SUPPLEMENT: Individualized fortification of breast milk|DIETARY_SUPPLEMENT: Routine fortification of breast milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multisensory Environment Room in Children With Autism Spectrum Disorder
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Autism
Interventions: OTHER: Training in the multisensory room environment|OTHER: Home program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CKD-11101 Phase 3 IV Study in Patients Who Had Renal Anemia Receiving Hemodialysis
Status: COMPLETED
Conditions: Anemia of Chronic Kidney Disease
Interventions: BIOLOGICAL: CKD-11101|BIOLOGICAL: NESP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Simplification of CF-related Diabetes Screening at Home
Status: COMPLETED
Conditions: Cystic Fibrosis|Cystic Fibrosis-related Diabetes
Interventions: DIAGNOSTIC_TEST: Standard OGTT|DIAGNOSTIC_TEST: Home-based OGTT (Beverage)|DIAGNOSTIC_TEST: Home-based OGTT (Candy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: The Effect of Duloxetine on Mood, Quality of Life and Cognitive Functioning in Glioblastoma Patients
Status: TERMINATED
Conditions: Depression
Interventions: DRUG: duloxetine|DRUG: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Biomechanical Forced During the Practice of Endoscopic Submucosal Dissection
Status: NOT_YET_RECRUITING
Conditions: Endoscopic Submucosal Dissection|Physiology|Musculoskeletal Disorders
Interventions: PROCEDURE: Performing endoscopic examinations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Almonertinib Vs. Erlotinib/Chemotherapy for Neo-adjuVant Treatment of Stage IIIA-N2 EGFR-mutated NSCLC
Status: NOT_YET_RECRUITING
Conditions: Non-Small Cell Lung Cancer Stage IIIA
Interventions: DRUG: Almonertinib|DRUG: Erlotinib|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spirometry Interpretation Performance of Primary Care Clinicians With/Without AI Software
Status: RECRUITING
Conditions: Lung Disease
Interventions: OTHER: Artificial Intelligence-powered Spirometry Interpretation Report
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluate Safety, Tolerability and Pharmacokinetics of HLX22 in Patients With Advanced Solid Tumors Overexpressing HER2
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: HLX22
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of Heat Stress Limit Values for the Athletic Performance
Status: COMPLETED
Conditions: Physiological Stress|Heat Stress|Sports Injury|Heat Stress, Exertional
Interventions: DIAGNOSTIC_TEST: analytical determination and interpretation of heat stress using calculation of the Predicted Heat Strain and Wet Bulb Globe Temperature
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Biomarker Trial to Evaluate the Efficacy of Itraconazole in Patients w/ Basal Cell Carcinomas
Status: COMPLETED
Conditions: Basal Cell Carcinoma (BCC)|Skin Cancer
Interventions: DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Melatonin on Sleep Disturbances in Patients With Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: DRUG: Melatonin(Circadin®)|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: North Carolina Newborn Exome Sequencing for Universal Screening
Status: COMPLETED
Conditions: Metabolism, Inborn Errors|Hearing Loss|Hereditary Disease
Interventions: GENETIC: Well infant, whole exome sequencing|GENETIC: Diagnosed, whole exome sequencing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Vitamin D and Calcium Supplementation on the Prevention of Stress Fractures.
Status: UNKNOWN
Conditions: Stress Fracture|Vitamin d
Interventions: DRUG: Vitamin D, Calcium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of Resting and Exercising Body Functioning in Freeman-Sheldon Syndrome and Related Conditions
Status: WITHDRAWN
Conditions: Arthrogryposis|Craniofacial Abnormalities
Interventions: OTHER: Lactate, Glucose, and Adenosine Triphosphate Blood Levels|PROCEDURE: Physiological Stress Test|OTHER: Functional Enquiry Form|OTHER: Strength, Joint ROM, Girth and Length Measurements|OTHER: Study Physical Examination|OTHER: Observational Gait Analysis|OTHER: Mental Health Interview
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Location of Lower Extremity Deep Vein Thrombosis by Emergency Physicians Using Portable Compression Ultrasonography
Status: TERMINATED
Conditions: Deep Vein Thrombosis
Interventions: PROCEDURE: portable venous compression ultrasonography|PROCEDURE: venous compress ultrasonography|PROCEDURE: Doppler ultrasound of the lower limbs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Computerized Virtual Reality in Elderly
Status: COMPLETED
Conditions: Cognitive Dysfunction|Cognitive Change|Independent Living|Quality of Life|Video Games
Interventions: BEHAVIORAL: Computerized virtual reality training programs group (Hot-Plus group)|BEHAVIORAL: Social interaction group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Human Cerebral Blood Flow and Serotonin
Status: NOT_YET_RECRUITING
Conditions: Depression|Serotonin Deficiency
Interventions: DRUG: Pharmacological agent: Citalopram|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 1/2 Study of CAN103 in Subjects With Gaucher Disease
Status: RECRUITING
Conditions: Gaucher Disease, Type 1|Gaucher Disease, Type 3
Interventions: DRUG: Low-dose CAN103|DRUG: High-dose CAN103
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of Marketed Contact Lens Disinfectant Systems on Eyelid Tissues
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: AOSEPT® Plus contact lens solution|DEVICE: ReNu MultiPlus® contact lens solution|DEVICE: Etafilcon A contact lenses|DEVICE: Lotrafilcon B contact lenses|DEVICE: COMPLETE® MPS Easy Rub® Formula contact lens solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Reducing Postoperative Side Effect of Pregabalin
Status: COMPLETED
Conditions: Pain, Postoperative|Arthroplasty, Replacement, Knee|Arthroplasty, Replacement, Hip
Interventions: DRUG: 37.5mg Pregabalin + 75mg Pregabalin|DRUG: 75mg Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, Pharmacokinetic, Including Food Interaction, and Pharmacodynamic Profile of BIA 5-1058.
Status: COMPLETED
Conditions: Hypertension and Chronic Heart Failure
Interventions: DRUG: BIA 5-1058|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy of BioCartilage® Micronized Cartilage Matrix in Microfracture Treatment of Osteochondral Defects
Status: UNKNOWN
Conditions: Osteochondral Defect
Interventions: DEVICE: BioCartilage® Micronized Cartilage Matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: Placebo|DRUG: Propofol|DRUG: Thiopental
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Neurally Adjusted Ventilatory Assist (NAVA) Study in Adults With Acute Respiratory Failure
Status: COMPLETED
Conditions: Acute Respiratory Failure
Interventions: OTHER: NAVA ventilation|OTHER: Conventional Lung Protective Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Pharmacokinetics and Safety of Meropenem in Infants Below 90 Days With Clinical or Confirmed Late-onset Sepsis
Status: COMPLETED
Conditions: Sepsis
Interventions: DRUG: Meropenem|DRUG: Ampicillin + gentamicin or cefotaxime + gentamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-DOPA-PET/MRI Scan in Imaging Elderly Patients With Newly Diagnosed Grade IV Malignant Glioma or Glioblastoma During Planning for a Short Course of Proton Beam Radiation Therapy
Status: COMPLETED
Conditions: Glioblastoma|Malignant Glioma
Interventions: PROCEDURE: Computed Tomography|OTHER: Fluorodopa F 18|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|RADIATION: Proton Beam Radiation Therapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Morphologic and Biometric Characteristics of Preexisting Posterior Capsule Defects in Congenital Cataracts During the First Year of Life
Status: UNKNOWN
Conditions: Congenital Cataract
Interventions: PROCEDURE: cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Goniocurettage as First Choice of Surgical Treatment in Chronic Open-Angle Glaucoma: Outcomes and Complications
Status: UNKNOWN
Conditions: Open-Angle Glaucoma|Surgery
Interventions: PROCEDURE: Goniocurettage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CEDARS Intervention: A Coping, Emotional Development, & Stress Reduction Intervention
Status: NOT_YET_RECRUITING
Conditions: Adolescent Behavior|Stress Reduction|Adverse Childhood Experiences
Interventions: BEHAVIORAL: CEDARS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Clinical Study of Recombinant Novel Coronavirus Vaccine
Status: UNKNOWN
Conditions: Coronavirus
Interventions: BIOLOGICAL: Recombinant new coronavirus vaccine (CHO cell) low-dose group|BIOLOGICAL: Recombinant new coronavirus vaccine (CHO cells) high-dose group|BIOLOGICAL: Recombinant new coronavirus vaccine (CHO cells) placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Study: Use of the Saccadometer to Detect Characteristic Saccadic Peak Velocity in Myasthenia Gravis Patients
Status: COMPLETED
Conditions: Myasthenia Gravis
Interventions: DEVICE: Quantitative measurement of eye movements
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Sugammadex (MK-8616/Org 25969) With Neostigmine Administered at 1-2 Post-tetanic Counts (PTCs) After Administration of Rocuronium or Vecuronium (19.4.302/P05945/MK-8616-025)
Status: COMPLETED
Conditions: Anesthesia, General
Interventions: DRUG: sugammadex|DRUG: neostigmine|DRUG: vecuronium|DRUG: rocuronium|DRUG: glycopyrrolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing AC0010 and Chemotherapy in Patients With Advanced NSCLC Who Have Progressed Following Prior EGFR TKI
Status: WITHDRAWN
Conditions: NSCLC
Interventions: DRUG: Pemetrexed|DRUG: Cisplatin 75mg/m2|DRUG: AC0010
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Performance of Treatment of Articular Cartilage Lesions Located on the Femoral Condyle With gelrinC
Status: UNKNOWN
Conditions: Cartilage Lesion to the Femoral Condyle
Interventions: DEVICE: GelrinC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Levomilnacipran ER (Levomilnacipran SR) in Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Levomilnacipran ER|DRUG: Levomilnacipran ER|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Efficacy and Safety of CT-P13 Subcutaneous as Induction Therapy in Patients With Active CD or UC
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases
Interventions: DRUG: CT-P13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PREVENTING PNEUMOcoccal Disease Through Vaccination (Study 2)
Status: RECRUITING
Conditions: Streptococcus Pneumonia
Interventions: BIOLOGICAL: PPV23|BIOLOGICAL: PCV13|OTHER: Saline for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial of Abluminus DES+ Sirolimus Eluting Stent Versus Everolimus-eluting DES
Status: COMPLETED
Conditions: Coronary Artery Disease|Diabetes
Interventions: DEVICE: device implantation during coronary angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ph II of Capecitabine, Carboplatin & Bevacizumab for Gastroesophageal Junction & Gastric Carcinoma
Status: COMPLETED
Conditions: Stomach Cancer|Gastric (Stomach) Cancer|Neoplasm of Cardioesophageal Junction|Gastrointestinal Stromal Tumor (GIST)
Interventions: DRUG: bevacizumab|DRUG: carboplatin|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravenous Infusion of Lidocaine and Remifentanil Perioperatively in Patients Undergoing Mastectomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Lidocaine|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Ferric Carboxymaltose on Hemoglobin and Blood Transfusion in Cardiac Surgery
Status: UNKNOWN
Conditions: Anemia
Interventions: DRUG: Ferinject|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effectiveness of the Initial Specimen Diversion Device When Collected Through Peripheral Intravenous Catheters
Status: TERMINATED
Conditions: Septicemia
Interventions: DEVICE: Initial Specimen Diversion Device (ISDD)|PROCEDURE: Lab standard practice (LSP)|DEVICE: Peripheral Intravenous Catheters (PIVC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: veRy Thin Stents for Patients With Left mAIn or bifurcatioN in Real Life: the RAIN a Multicenter Study
Status: COMPLETED
Conditions: Stent Restenosis|Stent Thrombosis|Left Main Coronary Artery Disease|Coronary Bifurcations|Very Thin Stents
Interventions: DEVICE: Xience alpine, ultimaster, resolute onyx, synergy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Baclofen Effects on Smoking Urge and Withdrawal
Status: TERMINATED
Conditions: Nicotine Use Disorder|Nicotine Dependence|Smoking|Tobacco Use Disorder
Interventions: DRUG: Baclofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation do Early Pars Plana Vitrectomy in Acute Endophthalmitis
Status: COMPLETED
Conditions: Endophthalmitis
Interventions: DRUG: Intravitreal Antibiotic Injection|PROCEDURE: Pars Plana Vitrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SeriACL™ Device Trial for Anterior Cruciate Ligament (ACL) Reconstruction
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament|Knee Injuries
Interventions: DEVICE: ACL Reconstruction (SeriACL™ Device)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety and Efficacy of Intravenous Tigecycline to Treat Hospitalized Japanese Subjects
Status: COMPLETED
Conditions: Community-Acquired Infections
Interventions: DRUG: tigecycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The SILVER Study: Systolic Hypertension Interaction With Left Ventricular Remodeling
Status: COMPLETED
Conditions: Hypertension|Hypertrophy, Left Ventricular
Interventions: DRUG: ALT-711
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Roflumilast in Japanese Patients Older Than 40 Years With Chronic Obstructive Pulmonary Disease (APTA-2217-06)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Roflumilast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Lt to Rt Shunt Using Veno-veno-arterial Extracorporeal Membrane Oxygenation (ECMO) on Coronary Oxygenation in Lung Transplantation Patients
Status: COMPLETED
Conditions: Interstitial Pulmonary Fibrosis ARDS|COPD (Chronic Obstructive Pulmonary Disease)|Bronchiectasis|Lymphangioleiomyomatosis|Primary Pulmonary Hypertension|ARDS (Acute Respiratory Distress Syndrome)
Interventions: PROCEDURE: Veno-veno-arterial ECMO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part II) (DCLI-II)
Status: UNKNOWN
Conditions: Vascular Diseases|Diabetes
Interventions: DEVICE: Percutaneous Transluminal Angioplasty|DEVICE: below-knee arterial bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic Supplements in Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Acetylcholinesterase Inhibitors to Improve Cognitive Function and Overall Rehabilitation After a Stroke
Status: COMPLETED
Conditions: Cerebrovascular Accident
Interventions: DRUG: Galantamine|DRUG: Donepezil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Family Group Interventions for People With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: mutual support group|BEHAVIORAL: psychoeducation group|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Protein Digestion and Amino Acid Absorption in the Aging Gastrointestinal Tract
Status: NOT_YET_RECRUITING
Conditions: Protein Malabsorption
Interventions: OTHER: Gastroscopy with duodenal mucosal tissue biopsies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Trial to Study Quality of Life in Prostate Cancer Patients by Randomizing Anti-androgen Versus Total Androgen Blockage Prior to Curative Intended Radiation Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Bicalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combivent Respimat 1-year Safety Study in Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Combivent CFC-MDI|DRUG: Combivent Respimat 20/100 mcg|DRUG: Atrovent HFA 42 mcg + Albuterol HFA 200 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemotherapy + Herceptin in HER2 Positive Stage II-III Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Neoplasm
Interventions: DRUG: epirubicin|DRUG: cyclophosphamide|DRUG: docetaxel|DRUG: trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Treatment of Acute Otitis Media Through Tympanostomy Tubes (AOMT) and Its Effect on Microbial Flora
Status: COMPLETED
Conditions: Acute Otitis Media
Interventions: DRUG: Ciprofloxacin 0.3% and dexamethasone 0.1% otic suspension
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: OPtimisation of Antiviral Therapy in Immunocompromised COVID-19 Patients: a Randomized Factorial Controlled Strategy Trial
Status: RECRUITING
Conditions: COVID-19|Immunodeficiency
Interventions: DRUG: Paxlovid 5 days|DRUG: Paxlovid 10 days|DRUG: Veklury
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effect of Etoricoxib (ARCOXIA®) 120MG During Retinal Laser Photocoagulation
Status: COMPLETED
Conditions: Proliferative Diabetic Retinopathy
Interventions: DRUG: placebo (Control Group)|DRUG: Etoricoxib (Treatment Group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Rising Dose Trial of Spesolimab (BI 655130) for Healthy Japanese Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Spesolimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ureteral Stent Versus Percutaneous Nephrostomy in Acutely Obstructed Infected Kidney
Status: COMPLETED
Conditions: Management of Obstructed Infected Kidney
Interventions: PROCEDURE: Ureteral stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Two Doses of Oral HDV-Insulin and Placebo With Background Metformin Treatment in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: placebo|DRUG: Oral Hepatic Directed Vesicles (HDV)-Insulin (U-15)|DRUG: Oral Hepatic Directed Vesicles (HDV)-Insulin (U-5)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Controlled Schroth Exercise and Home Exercise Programs
Status: COMPLETED
Conditions: Scoliosis Idiopathic|Scoliosis; Adolescence
Interventions: OTHER: Schroth Exercise Group|OTHER: Home Exercise Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Male Subjects to Investigate Whether Administration of Rifampicin Can Affect the Fate of Clazosentan in the Body of Clazosentan
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Clazosentan|DRUG: Rifampicin|OTHER: Saline (0.9% sodium chloride)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study To Assess Distribution Of RO7248824 In The Central Nervous System Following Single Intrathecal Doses Of [89zr] Labeled RO7248824 In Healthy Male Participants
Status: COMPLETED
Conditions: Angelman Syndrome
Interventions: DRUG: RO7248824
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D Oral Supplements on 25 OH Vitamin D Levels
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DRUG: ergocalciferol 2000 IU orally, daily|DRUG: ergocalciferol 25000 IU oraly every 2 weeks|DRUG: ergocalciferol 50000 IU orally every 4 weeks|DRUG: ergocal1000 IU & cholecal 1000 IU orally daily|DRUG: cholecalciferol 2000 IU orally daily|DRUG: Cholecalciferol 25000 IU orally every 2 weeks|DRUG: Cholecalciferol 50000 orally every 4 weeks|DRUG: placebo orally everyday
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Evaluate JCXH-108, an mRNA-based Vaccine Against RSV
Status: NOT_YET_RECRUITING
Conditions: Respiratory Syncytial Virus (RSV)|Infectious Disease
Interventions: BIOLOGICAL: JCXH-108|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Management of Initial Bleeding/Spotting Associated With the Levonorgestrel-releasing Intrauterine System (MIRENA)
Status: COMPLETED
Conditions: Uterine Hemorrhage
Interventions: DRUG: Tranexamic acid|DRUG: Mefenamic acid|DRUG: Placebo|DRUG: Mirena (Levonorgestrel IUS, BAY86-5028)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mitomycin C With Hyperthermia and Intravesical Mitomycin C to Treat Recurrent Bladder Cancer
Status: COMPLETED
Conditions: Transitional Cell Carcinoma of Bladder|Superficial Bladder Cancer
Interventions: DEVICE: Hyperthermia System|DRUG: Mitomycin C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ovarian Cancer Treatment With a Liposome Formulated mRNA Vaccine in Combination With (Neo-)Adjuvant Chemotherapy
Status: TERMINATED
Conditions: Ovarian Cancer
Interventions: DRUG: W_ova1 Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Pembrolizumab Combination in EBER-ISH Positive NPC
Status: UNKNOWN
Conditions: Locally Recurrent Cancer|Metastatic Nasopharyngeal Cancer
Interventions: DRUG: pembrolizumab|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 12-Week, Double-Blind, Placebo-Controlled Study of 20 and 60 mg/Day Istradefylline in Parkinson's Disease Patients on Levodopa/Carbodopa
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Istradefylline (KW-6002)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Dose-Escalation Trial of Carfilzomib With and Without Romidepsin in Cutaneous T-Cell Lymphoma
Status: TERMINATED
Conditions: Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Stage I Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IA Mycosis Fungoides/Sezary Syndrome|Stage IB Mycosis Fungoides/Sezary Syndrome|Stage II Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IIA Mycosis Fungoides/Sezary Syndrome|Stage IIB Mycosis Fungoides/Sezary Syndrome|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IIIA Mycosis Fungoides/Sezary Syndrome|Stage IIIB Mycosis Fungoides/Sezary Syndrome|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IVA Mycosis Fungoides/Sezary Syndrome|Stage IVB Mycosis Fungoides/Sezary Syndrome
Interventions: DRUG: carfilzomib|DRUG: romidepsin|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Routine Antibiotic Prescription Monitoring in Primary Care Physicians: A Nationwide Trial
Status: COMPLETED
Conditions: Acute Respiratory Tract Infection|Urinary Tract Infections
Interventions: BEHAVIORAL: Antibiotic stewardship program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Technology Based Community Health Nursing(TECH-N) to Prevent Recurrent STIs After PID II
Status: ACTIVE_NOT_RECRUITING
Conditions: Pelvic Inflammatory Disease
Interventions: BEHAVIORAL: Tech-PN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment Shortening of MDR-TB Using Existing and New Drugs
Status: UNKNOWN
Conditions: Tuberculosis, Multidrug-Resistant
Interventions: DRUG: Linezolid|DRUG: Delamanid|DRUG: Levofloxacin|DRUG: Pyrazinamide|DRUG: Locally-used WHO-approved MDR-TB regimen in Korea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT