pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Zomig - Treatment of Acute Migraine Headache in Adolescents
Status: COMPLETED
Conditions: Migraine Headache
Interventions: DRUG: Placebo|DRUG: Zolmitriptan|DRUG: Zolmitriptan|DRUG: Zolmitriptan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PREFER (Pacemaker Remote Follow-Up Evaluation and Review)
Status: COMPLETED
Conditions: Bradycardia|Arrhythmia
Interventions: OTHER: Transtelephonic monitoring (TTM)|OTHER: Medtronic CareLink® Network
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, PK & Efficacy of V81444 in Volunteers With Attention Deficit/ Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: V81444|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Mechanical Penetration Enhancers on Metvixia Skin Penetration
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: occlusive bandage|DEVICE: ablative fractional CO2 laser pretreatment|DEVICE: Microneedles pretreatment|DRUG: METVIXIA Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: BAX 802 in CHA With Inhibitors
Status: TERMINATED
Conditions: Hemophilia A
Interventions: BIOLOGICAL: Antihemophilic Factor (Recombinant), Porcine Sequence (BAX 802)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: AZD0305
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NSAIDs and PGE2 Levels in Vitrectomy Patients
Status: COMPLETED
Conditions: Vitreous Inflammation
Interventions: DRUG: Ketorolac 0.5% eyedrops|DRUG: Indomethacin 0.5% eyedrops|DRUG: Bromfenac 0.09% eyedrops|DRUG: Nepafenac 0.1% eyedrops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using of Extra Virgin Olive Oil in Hemodialysis Patients to Improve Pruritus and Sleep Disorders
Status: UNKNOWN
Conditions: Uremic Pruritus
Interventions: OTHER: Olive oil application in hemodialysis patients with pruritus|OTHER: Normal saline application in hemodialysis patients with pruritus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Eltrombopag With Decitabine in Advanced Myelodysplastic Syndrome (MDS)
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: Eltrombopag|DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study on the Pharmacokinetics and Safety of RLYB212 in Pregnant Women at Higher Risk for HPA-1a Alloimmunization
Status: NOT_YET_RECRUITING
Conditions: Fetal and Neonatal Alloimmune Thrombocytopenia
Interventions: DRUG: Anti-(integrin beta-3) human monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: STARLITE for Unresectable High-Grade Gliomas
Status: NOT_YET_RECRUITING
Conditions: High Grade Glioma
Interventions: PROCEDURE: Magnetic Resonance (MR)-guided Laser Interstitial Thermal Therapy (LITT)|DRUG: Abacavir|DRUG: Lamivudine|DRUG: Ritonavir|DRUG: Temozolomide|RADIATION: Focal Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Provisional-Crown Surface Coating on Biofilm Formation
Status: COMPLETED
Conditions: Dental Plaque
Interventions: PROCEDURE: coating a dental restoration material ,polymethylmethacrylate, with liquid polish resin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety and Efficacy of NKTR-102 in Patients With Metastatic or Locally Advanced Breast Cancer
Status: COMPLETED
Conditions: Tumor|Breast Cancer
Interventions: DRUG: NKTR-102|DRUG: NKTR-102
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Indications for Ultrasound in the Staging of Cervical Cancer
Status: WITHDRAWN
Conditions: Cervical Cancer
Interventions: PROCEDURE: biopsy|DEVICE: 3d-ultrasound and fusion of UL and PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Impact of Retropubic Lidocaine vs Saline on Postoperative Urinary Retention Following Midurethral Sling
Status: RECRUITING
Conditions: Stress Urinary Incontinence
Interventions: DRUG: lidocaine with epinephrine|DRUG: Normal saline with epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: IVAC-RCC-001: A Personalized Neoantigen Vaccine as Add-on to Standard of Care Checkpoint Inhibitor in Advanced/Metastatic RCC Patients
Status: RECRUITING
Conditions: Advanced Renal Cell Carcinoma
Interventions: BIOLOGICAL: IVAC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase II Study of Perioperative S-1 Plus Docetaxel in Patients With Localized Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Stomach Neoplasms
Interventions: DRUG: S-1,Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Metabolic Effects of Prebiotic Supplementation After Roux-en-Y Gastric Bypass Surgery
Status: COMPLETED
Conditions: Bariatric Surgery
Interventions: DIETARY_SUPPLEMENT: Prebiotic|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: OTHER: AIH|OTHER: Walk|OTHER: Strength
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study Evaluating the Incidence of Post Lumbar Puncture Headache With Atraumatic Needles in Hematology
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: DEVICE: Standard needle|DEVICE: Atraumatic needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Preliminary Evaluation of [68Ga]CBP8 in Healthy Individuals, Lung Cancer, and Idiopathic Pulmonary Fibrosis Patients
Status: RECRUITING
Conditions: Pulmonary Fibrosis|Lung Cancer
Interventions: DRUG: [68Ga]CBP8|DIAGNOSTIC_TEST: PET Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Apatinib As Third Line Therapy in Patients With Advanced Ovarian Cancer
Status: UNKNOWN
Conditions: Angiogenesis Inhibitors，Ovarian Neoplasms
Interventions: DRUG: apatinib|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Erector Spinae Plane Block vs Intravenous Lidocaine for Chronic Pain Post Mastectomy.
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Surgery
Interventions: DRUG: Lido-IV|DRUG: ESP Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy and Safety of Iguratimod (IGU) in the Treatment of Primary Sjögren's Syndrome
Status: UNKNOWN
Conditions: Primary Sjögren's Syndrome
Interventions: DRUG: Iguratimod Tablets|DRUG: Hydroxychloroquine Sulfate Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of High-flow Nasal Cannula Oxygen Therapy in Patients With Obstructive Sleep Apnea
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: high-flow nasal cannula oxygen therapy,|DEVICE: CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Healthy Living Partnership to Prevent Diabetes
Status: COMPLETED
Conditions: Prediabetes|Obesity
Interventions: BEHAVIORAL: Group-Based Lifestyle Intervention (Phases 1 and 2)|OTHER: Individual Education Program (All Phases)|BEHAVIORAL: Self-Directed Maintenance (Phase 3)|BEHAVIORAL: Extended Group Maintenance (Phase 3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Improvement of Nutrition Status, Digestive Conditions, and Upper Respiratory Infections by Using Oral Nutritional Supplementation on Children in Vietnam
Status: COMPLETED
Conditions: Wasting|Undernutrition|Malnourished|Malnutrition
Interventions: DIETARY_SUPPLEMENT: Colos Gain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Telerehabilitation in Patients With COVID-19 After Hospitalization. The ATHLOS Study
Status: COMPLETED
Conditions: COVID-19|Comorbidities and Coexisting Conditions
Interventions: DEVICE: Telerehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early-goal Directed Automated Red Blood Cell Exchange for Acute Chest Syndrome in Sickle Cell Disease
Status: NOT_YET_RECRUITING
Conditions: Acute Chest Syndrome
Interventions: PROCEDURE: Red blood cell EXchange (REX)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Phenoxybenzamine [PBZ] IV to Assist High Flow Low Pressure Perfusion [HFLPP] on Cardio-pulmonary Bypass
Status: TERMINATED
Conditions: Congenital Heart Surgery|Cardiopulmonary Bypass
Interventions: DRUG: Phenoxybenzamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coenzyme Q10 Role in Prevention of Contrast Induced Nephropathy in Acute Coronary Syndrome Patients.
Status: RECRUITING
Conditions: Contrast-induced Nephropathy
Interventions: DRUG: Coenzyme Q10 100 Milligrams Oral Capsule|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Radiosurgery or Open Surgery for Epilepsy Trial
Status: COMPLETED
Conditions: Epilepsy
Interventions: PROCEDURE: radiosurgery|PROCEDURE: temporal lobectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized Maintenance Therapy for m-PDAC Using Olaparib or Selumetinib + Durvalumab, Based on BRCAness and KRAS Status.
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: Arm A - Olaparib|DRUG: ARM B - durvalumab plus selumetinib|DRUG: ARM C FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home Monitoring of Adult Patients With SMA: a Pilot Multicenter Validation Study
Status: NOT_YET_RECRUITING
Conditions: Muscular Atrophy, Spinal, Type II|Muscular Atrophy, Spinal, Type III
Interventions: OTHER: Strength force measurment|OTHER: Time tests|OTHER: Motor scales|OTHER: Questionnaires|DEVICE: Accelerometry|OTHER: MNR|OTHER: Bio-impedance analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase II Trial Comparing Z-102 With Placebo In Patients With Moderate To Severe Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Prednisolone|DRUG: dipyridamole|DRUG: Prednisone|DRUG: Z102|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dexmedetomidine on Parturient Undergoing Elective Cesarean Section.
Status: COMPLETED
Conditions: Cesarean Section
Interventions: DRUG: dexmedetomidine group|DRUG: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Randomized Comparison of JUDkins vs tiGEr Catheter in Coronary Angiography Via the Right Radial Artery: the JUDGE Study
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Tiger cardiac catheter|DEVICE: Judkins 3.5L/4R cardiac catheters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Lateral Rectus Muscle Tendon Elongation
Status: COMPLETED
Conditions: Surgical Procedure, Unspecified|Ocular Discomfort|Strabismus, Divergent
Interventions: PROCEDURE: LATERAL RECTUS MUSCLE AUGMENTED RECESSION BY ELONGATION OF THE TENDON WITH AUTOGRAFT FROM RESECTED MEDIAL RECTUS MUSCLE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double Stimulation Followed by a Fresh Embryo Transfer
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Double Stimulation (Elonva+rFSH) in luteal /follicular phase|DRUG: Conventional Stimulation (Elonva+rFSH) in follicular phase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Efficiency of Techniques of 'Snail ' and 'Go-back' Application of an Alcoholic Antiseptic on Healthy Skin Before the Placement of a Intra-vascular Device,
Status: COMPLETED
Conditions: Health Care Utilization
Interventions: PROCEDURE: antiseptic application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy Evaluation of Observation Unit Cardiac Magnetic Resonance Imaging (MRI) in Patients With Intermediate Risk Acute Chest Pain
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Chest Pain
Interventions: OTHER: OU - Cardiac MRI|OTHER: OU - Conventional Care Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Direct and Indirect Protection by Influenza Vaccine Given to Children in India
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Inactivated Trivalent Influenza Vaccine|BIOLOGICAL: Inactivated polio vaccine (IPV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: LCS16 vs. COC User Satisfaction and Tolerability Study
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Levonorgestrel (Kyleena, BAY86-5028)|DRUG: Ethinyl estradiol and drospirenone (Yarina, BAY86-5131)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemoembolization With or Without Stereotactic Body Radiosurgery for Liver Cancer
Status: WITHDRAWN
Conditions: Carcinoma, Hepatocellular
Interventions: PROCEDURE: Transarterial Chemoembolization (TACE)|RADIATION: TACE+Stereotactic Body Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics (PK) Study of Single Ascending Doses of CVT-427 (Zolmitriptan Inhalation Powder) In Healthy Adults
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: zolmitriptan|DRUG: CVT-427 (zolmitriptan inhalation powder),
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Negative Symptoms of Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: Placebo|DRUG: AVP-786
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determining the Responsiveness of Intestinal Lipoprotein Production to an Elevation of Plasma Free Fatty Acids
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: DRUG: Intravenous Intralipid|DRUG: Intravenous leucine, glycerol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Buccal Bone Resorption in Immediate SLActive Implant Placement Thin vs. Thick Buccal Bone
Status: COMPLETED
Conditions: Dental Implant|Immediate Implant
Interventions: DEVICE: immediate implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Synergistic Sequential Treatment (SST)
Status: COMPLETED
Conditions: Improvement of Wrinkles/Elastosis as Well as General Skin Tone
Interventions: DEVICE: M22 ResurFX|DEVICE: M22 ResurFX and QS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparation of Radial and Focused Extracorporeal Shock Waves in Calcaneal Spur: A Randomised Sham-controlled Trial
Status: COMPLETED
Conditions: Calcaneal Spur
Interventions: DEVICE: Focus extracorporeal shock wave therapy|DEVICE: Radial extracorporeal shock wave therapy|DEVICE: Sham extracorporeal shock wave therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ginkgo Diterpene Lactone Meglumine Injection on Platelet Reactivity in Acute Ischemic Stroke
Status: UNKNOWN
Conditions: Ischemic Stroke
Interventions: DRUG: Ginkgo Diterpene Lactone Meglumine Injection|DRUG: Acetylsalicylic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Excretion of Orally Administered Corticosteroids for the Improval of the Detection of Said Substances in Anti-doping Controls
Status: UNKNOWN
Conditions: Healthy Volunteers
Interventions: DRUG: Methylprednisone|DRUG: Methylprednisone|DRUG: Deflazacort|DRUG: Dexamethasone|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Tolerability and Pharmacokinetics of Two Single and Multiple High Dose Regimens of BIA 2-093 In Healthy Volunteers
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: BIA 2-093 - 1800 mg (Group 1)|DRUG: BIA 2-093 - 2400 mg (Group 2)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Lichen Sclerosus
Status: COMPLETED
Conditions: Lichen Sclerosus
Interventions: DRUG: Ruxolitinib cream|DRUG: Vehicle cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aftercare Focus Study (AFS): A Clinical Trial to Reduce Short-Term Suicide Risk After Hospitalization
Status: COMPLETED
Conditions: Suicidal Ideation|Suicide, Attempted|Distress, Psychological|Quality of Life
Interventions: BEHAVIORAL: Collaborative Assessment and Management of Suicidality|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ticagrelor Versus Clopidogrel in Carotid Artery Stenting
Status: COMPLETED
Conditions: Carotid Artery Stenosis
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaping and Smoking Withdrawal Project
Status: RECRUITING
Conditions: Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)
Interventions: BEHAVIORAL: Acute (24-hour) abstinence|BEHAVIORAL: Ad libitum smoking/vaping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Quantum Molecular Resonance Combined With Intense Pulsed Light in Mixed Dry Eye
Status: COMPLETED
Conditions: Dry Eye
Interventions: DEVICE: Quantum Molecular Resonance (QMR) Therapy|DEVICE: Intense Pulsed Light (IPL) Therapy|DRUG: Tear Substitute Treatment (Supportive Therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ER Reactivation Therapy for Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: 17B-estradiol|DRUG: Letrozole|DRUG: Anastrozole|DRUG: Exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The ACCT2 Study Individuals With Type 2 Diabetes and Non-Western Backgrounds (ACCT2)
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Person-centred culturally sensitive course of treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of a Resistance Training Intervention on Blood Pressure Control in Older Adults With Sarcopenia
Status: COMPLETED
Conditions: Sarcopenia|High Blood Pressure|Hypertension
Interventions: BEHAVIORAL: progressive resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Novel Deep Brain Stimulation in Ventral Capsule and Stratum for Refractory Obsessive-Compulsive Disorder
Status: UNKNOWN
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: deep brain stimulation system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Effect of Obicetrapib in Patients With HeFH on Top of Maximum Tolerated Lipid-Modifying Therapies.
Status: COMPLETED
Conditions: Dyslipidemias|High Cholesterol|Hypercholesterolemia|Familial Hypercholesterolemia|Lipid Metabolism Disorder|Metabolic Disease|Lipid Metabolism, Inborn Errors|Genetic Disease, Inborn|Hyperlipoproteinemias
Interventions: DRUG: Obicetrapib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Nutritional Optimization in Head and Neck Cancer Patients
Status: RECRUITING
Conditions: Head and Neck Cancer
Interventions: DIETARY_SUPPLEMENT: Isocaloric and iso-nitrogenous standard enteral tube feeds|DIETARY_SUPPLEMENT: Nestle IMPACT AR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Different Irrigation Activation Techniques on Postoperative Pain After Endodontic Treatment
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Traditional Irrigation|DEVICE: Xp-endo Finisher (XPF)|DEVICE: Passive Ultrasonic Irrigation|DEVICE: EndoActivator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of an Intranasal Testosterone Product
Status: COMPLETED
Conditions: Hypogonadism
Interventions: DRUG: 10.0 mg of Testosterone, 4.0% TID|DRUG: 13.5 mg of Testosterone, 4.5% B.I.D|DRUG: 11.25 mg of Testosterone, 4.5% T.I.D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety/Efficacy of MEDI-551 in Combination With Immunomodulating Therapies in Subjects With Aggressive B-cell Lymphomas
Status: COMPLETED
Conditions: Relapsed/Refractory Aggressive B-cell Lymphomas
Interventions: DRUG: MEDI-551 12 mg/kg|DRUG: MEDI0680 2.5 mg/kg|DRUG: MEDI0680 10 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genasense as a 2-hour Intravenous Infusion in Subjects With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Oblimersen (Genasense)|DRUG: Oblimersen (Genasense)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in Healthy Subjects to Compare the Concentrations of the Omega-3 Fatty Acids EPA and DHA in Blood When Delivered as Three New Capsules in Relation to the Epanova® Capsule Under Fasting and Fed Conditions
Status: COMPLETED
Conditions: Relative Bioavailability|AUC|Cmax|Pharmacokinetics
Interventions: DRUG: D1400147|DRUG: D14000136|DRUG: D14000137|DRUG: Epanova®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNF Therapies.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: rituximab|DRUG: Methotrexate|DRUG: Corticosteroid or NSAID|DIETARY_SUPPLEMENT: Folate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence
Status: RECRUITING
Conditions: Twin Reversal Arterial Perfusion Syndrome
Interventions: PROCEDURE: Early selective reduction of TRAP mass|PROCEDURE: Late selective reduction of TRAP mass|DEVICE: Ultrasound-guided intrafetal ablation using a 18 to 20 Gauge needle|DEVICE: Ultrasound-guided intrafetal ablation using a 17 to 20 Gauge needle|DEVICE: Laser coagulation of the cord or anastomising vessels through a 17 Gauge to 7 French trocar, with a 1-1,3 mm fetoscope and a 400 µm laser fiber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2b Study of the Efficacy, Safety, and Tolerability of M1095 (Sonelokimab) in Subjects With Moderate to Severe Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: M1095 (Sonelokimab)|DRUG: Placebo|DRUG: Secukinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clodronate With or Without Chemotherapy and/or Hormonal Therapy in Treating Women With Stage I or Stage II Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: clodronate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Contralateral Clinical Trial With Single-piece (SN60WF) vs. Three Piece (MA60AC) AcrySof Intraocular Lenses (IOLs) on Development of Posterior Chamber Opacification (PCO).
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Model SN60WF|DEVICE: Model MA60AC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Association With the IMA950/Poly-ICLC for Relapsing Glioblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma Multiforme|Glioblastoma, Adult|Glioma of Brain|Glioblastoma Multiforme of Brain
Interventions: DRUG: IMA950/Poly-ICLC|DRUG: IMA950/Poly-ICLC and pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Supracostal Versus Subcostal Puncture in Adult PCNL
Status: ACTIVE_NOT_RECRUITING
Conditions: Urolithiasis
Interventions: COMBINATION_PRODUCT: PCNL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Supplementation With Blueberry in OA
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: Blueberry powder supplement|DIETARY_SUPPLEMENT: Maltodextrin supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fractional Ablative Radiofrequency for the Treatment of Acne Scars and Wrinkles
Status: COMPLETED
Conditions: Wrinkles|Acne Scars
Interventions: DEVICE: Alma Lasers Accent RF Pixel handpiece
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Splenectomy in Isolated High Grades Splenic Injuries
Status: COMPLETED
Conditions: Laparoscopic Surgery
Interventions: PROCEDURE: open splenectomy|PROCEDURE: laparoscopic splenectomy for splenic injury in trauma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stability of Short Implants Versus Standard Blx Implants With Internal Sinus Floor Elevation in Posterior Maxilla
Status: RECRUITING
Conditions: Bone Resorption
Interventions: PROCEDURE: surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: Rocatinlimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Application of Enteral Nutrition Program in Patients With Intra-abdominal Hypertension Oriented by Intra-abdominal Pressure
Status: COMPLETED
Conditions: Intra-Abdominal Hypertension
Interventions: BEHAVIORAL: enteral nutrition program for patients with abdominal hypertension guided by abdominal pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Ginger Extract on Postprandial Glycaemia of Healthy Adults and Its Antioxidant Properties
Status: COMPLETED
Conditions: Hyperglycemia, Postprandial
Interventions: OTHER: Placebo OGGT|OTHER: Ginger aqueous extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: RD13-02 CAR-T Cell Injection for Patients With r/r CD7+ T-ALL/T-LBL
Status: RECRUITING
Conditions: Neoplasms|Hematologic Neoplasms|Hematologic Diseases
Interventions: DRUG: RD13-02 cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Reactogenicity of Alternative Schedules of Gardasil
Status: COMPLETED
Conditions: Dose Schedule Study
Interventions: BIOLOGICAL: Biological: quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Effect of Vaginal ph and Acidification of Vaginal Misoprostol on Its Efficacy for Induction of Midtrimester Abortion
Status: UNKNOWN
Conditions: To Evaluate the Impact of the Vaginal Ph and Acidification of Vaginal Misoprostol on Its Efficacy in Facilitating Induction of Mid-trimester Abortion.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness and Safety of Physical Exercises in the Improvement of the Sleep Quality. Regarding Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: OTHER: Combined Training ( Strength + Aerobics)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cetuximab + Gemox in Biliary Tract Cancer
Status: COMPLETED
Conditions: Unresectable|Locally Advanced|Metastatic
Interventions: DRUG: Cetuximab + Gemcitabine + Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: Nivolumab/Ipilimumab-Primed Immunotransplant for DLBCL
Status: COMPLETED
Conditions: Relapsed Diffuse Large B-Cell Lymphoma|Refractory Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Ipilimumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PEEK Prostheses in the All-on-4 Concept Using Zygomatic Implants for Full-arch Rehabilitation.
Status: ENROLLING_BY_INVITATION
Conditions: Prosthesis Survival
Interventions: DEVICE: Prosthetic full-arch rehabilitation using a PEEK-acrylic resin prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TAP Using Dexmedetomidine and Ropivacaine for Cesarean Section Analgesia
Status: COMPLETED
Conditions: Multimodal Analgesia|Cesarean Section
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Combined RadioChemo-Molecular Target Therapy With Capecitabine, Bevacizumab, and Radiotherapy
Status: TERMINATED
Conditions: Rectal Cancer
Interventions: DRUG: capecitabine, bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Exercise in Normobaric Hypoxia and Normoxia in Type 1 Diabetic Patients
Status: COMPLETED
Conditions: type1diabetes
Interventions: BEHAVIORAL: Exercise in hypoxia|BEHAVIORAL: Exercise in normoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deescalating Carbapenems in Hospital Setting
Status: TERMINATED
Conditions: Urinary Infection|Digestive Infection|Biliary Infection|Expanded-spectrum Beta-lactamase Producing ESBL
Interventions: DRUG: Deescalation therapy|DRUG: Maintaining carbapenem therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pretransplant Evaluation by Supportive Care Team for Patients Undergoing HCT for Hematological Malignancies
Status: COMPLETED
Conditions: Malignancies, Hematologic
Interventions: OTHER: Palliative Care Support
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Long-term Investigation of Resveratrol in Obesity
Status: COMPLETED
Conditions: Obesity|Inflammation|Insulin Sensitivity|Osteoporosis
Interventions: DIETARY_SUPPLEMENT: Resveratrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pharmacokinetic Study to Evaluate the Effect of MAALOX on Raltegravir (MK-0518) in Human Immunodeficiency Virus (HIV)-Infected Participants (MK-0518-295)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Raltegravir (ISENTRESS™)|DRUG: MAALOX (MAL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrated HIV Prevention and HCV Care for PWID
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Prevention|HCV|Opioid Use|Intravenous Drug Usage
Interventions: BEHAVIORAL: ARTAS Adapted Patient Navigation|BEHAVIORAL: Adherence Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pomegranate-Extract Pill in Preventing Tumor Growth in Patients With Localized Prostate Cancer Undergoing Active Surveillance
Status: COMPLETED
Conditions: PSA Level Less Than or Equal to Fifteen|PSA Level Less Than Ten|Stage I Prostate Cancer AJCC v7|Stage II Prostate Cancer AJCC v7|Stage IIA Prostate Cancer AJCC v7|Stage IIB Prostate Cancer AJCC v7
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|OTHER: Placebo|DRUG: Pomegranate-Extract Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IBI362 in Overweight or Obesity Subjects
Status: COMPLETED
Conditions: Overweight or Obesity
Interventions: DRUG: IBI362|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Targeted Approach to Langerhans Cell Histiocytosis (LCH) Using MEK Inhibitor, Trametinib
Status: RECRUITING
Conditions: Langerhans Cell Histiocytosis
Interventions: DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conventional Surgery vs. Verion/VerifEye
Status: COMPLETED
Conditions: Cataract|Astigmatism
Interventions: DEVICE: Conventional|DEVICE: Refractive Cataract Suite (Verion + ORA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lavender Oil on Preoperative Anxiety and Sedation Requirement in General Anaesthesia
Status: COMPLETED
Conditions: Preoperative Anxiety
Interventions: OTHER: Lavender Oil on Nasal Strip (Lx)|OTHER: Strip without Lavender Oil (Px)|DRUG: Propofol 1 % Injectable Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: INSPIRES Hearing Health Trial - INnovative Psychological Intervention to REduce Stigma in Hearing Health Trial
Status: COMPLETED
Conditions: Hearing Loss
Interventions: BEHAVIORAL: Self-affirmation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hormonal Monitoring and Progesterone Adjustment in Frozen Embryo Transfer Cycles
Status: COMPLETED
Conditions: Female Infertility
Interventions: DRUG: estradiol valerate|OTHER: Hormonal monitoring progesterone, estradiol, luteinizing hormone|DIAGNOSTIC_TEST: transvaginal ultrasound examination|DRUG: Progesterone 400 Mg Vaginal Suppository|OTHER: Hormonal monitoring progesterone and estradiol|DRUG: Progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Fitusiran (ALN-AT3SC) in Severe Hemophilia A and B Patients Without Inhibitors
Status: COMPLETED
Conditions: Hemophilia A|Hemophilia B
Interventions: DRUG: fitusiran|DRUG: factor concentrates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Biomechanical Parameters of Unloading Braces Used in the Treatment of Knee Osteoarthritis (BIOoSE)
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Unloading brace|DEVICE: Rebel Reliever (RR)|DEVICE: Action Reliever
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peginterferon Lambda and Lonafarnib Boosted With Ritonavir 48-Week Combination Therapy for Delta Hepatitis
Status: WITHDRAWN
Conditions: Chronic Hepatitis Delta
Interventions: DRUG: Peginterferon Lambda
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Adding Extracorporeal Shock Wave Therapy to Physiotherapy and Corticosteroid Injection Beneficial for Frozen Shoulder
Status: NOT_YET_RECRUITING
Conditions: Frozen Shoulder|Corticosteroid Injection|Physical Therapy|Extracorporeal Shock Wave Therapy|Rehabilitation
Interventions: OTHER: ESWT+PT+corticosteroid injection, ESWT group|OTHER: Sham ESWT+PT+corticosteroid injection, SHAM group.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Dietary Fatty Acids as Complementary Therapy in Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Rosiglitazone (Avandia) OR other diabetes medication currently prescribed to participant|DIETARY_SUPPLEMENT: conjugated linoleic acid (CLA)|DIETARY_SUPPLEMENT: conjugated linoleic acid (CLA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Mobilization in Diabetic Neuropathy Subjects Receiving SB-509
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2|Diabetic Polyneuropathy
Interventions: DRUG: SB-509|DRUG: SB-509|DRUG: Placebo|DRUG: SB-509
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: IMPROVE: Mycophenolate Mofetil Versus Azathioprine for Maintenance Therapy in ANCA Associated Systemic Vasculitis
Status: TERMINATED
Conditions: ANCA Associated Systemic Vasculitis Including Wegener's|Granulomatosis and Microscopic Polyangiitis and|Renal Limited Vasculitis
Interventions: DRUG: Cyclophosphamide|DRUG: Mycophenolate mofetil|DRUG: Azathioprine|DRUG: Prednisone (and methylprednisolone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile Weight Loss Intervention for Adolescent and Young Adult Cancer Survivors
Status: RECRUITING
Conditions: Cancer|Physical Activity|Cancer Survivorship|Mental Health|Obesity
Interventions: BEHAVIORAL: AYA Connect intervention|BEHAVIORAL: Positive Psychology (PP) intervention|BEHAVIORAL: Positive Psychology Plus (PP+) intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Artificial Intelligence Prediction Tool in Thymic Epithelial Tumors
Status: RECRUITING
Conditions: Thymic Epithelial Tumor|Thymic Carcinoma|Thymoma|Thymoma and Thymic Carcinoma
Interventions: DIAGNOSTIC_TEST: Artificial Intelligence Diagnostics|DIAGNOSTIC_TEST: Recurrence Prediction Tool
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 2 Clinical Trial of NPI-0052 in Patients With Relapsed or Relapsed/Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: MRZ 0.5 mg/m^2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Pathway Activation Markers Predicting Efficacy of Trastuzumab Therapy for HER2-positive Breast Cancer
Status: UNKNOWN
Conditions: HER2-positive Breast Cancer
Interventions: OTHER: RNA sequencing|OTHER: Transcriptome analysis|DRUG: Trastuzumab|DRUG: Chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Donor Stem Cell Transplant in Treating Young Patients With Relapsed or Refractory Solid Tumors
Status: COMPLETED
Conditions: Neuroblastoma|Sarcoma|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: anti-thymocyte globulin|DRUG: busulfan|DRUG: cyclosporine|DRUG: melphalan|DRUG: methotrexate|DRUG: methylprednisolone|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation|PROCEDURE: umbilical cord blood transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cidofovir Versus Best Supportive Care for Hemorrhagic Cystitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Transplantation Infection
Interventions: DRUG: Cidofovir|OTHER: No Cidofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT