pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Head & Neck Cancer Survivorship: Physical and Functional Status
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: systemic chemotherapy|OTHER: survey administration|PROCEDURE: adjuvant therapy|PROCEDURE: management of therapy complications|PROCEDURE: musculoskeletal complications management/prevention|PROCEDURE: physical therapy|RADIATION: radiation therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Guidewire Use in Nasotracheal Intubation
Status: COMPLETED
Conditions: Epistaxis Nosebleed|Pharyngeal Bleeding
Interventions: DEVICE: Nasotracheal intubation with conventionally|DEVICE: Nasotracheal intubation with angled ETT using guidewire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Dose-escalation Study of LTX-315 in Patients With a Transdermally Accessible Tumour
Status: COMPLETED
Conditions: Cancer With Transdermal Accessible Tumour
Interventions: DRUG: LTX-315 (Oncopore™)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Regulated Add -on Sodium Chloride Intake on Stabilization of Serum Lithium Concentration in Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Affective Disorder
Interventions: DRUG: Lithium Carbonate|DRUG: Sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety of UV1 Vaccination in Combination With Ipilimumab in Patients With Unresectable or Metastatic Malignant Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Melanoma
Interventions: DRUG: Ipilimumab|BIOLOGICAL: UV1 vaccine|BIOLOGICAL: GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Cholecalciferol in Prevention of Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Prediabetes|Vitamin D Deficiency
Interventions: DRUG: oral cholecalciferol + life style counselling|DRUG: placebo + life style counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Assessing QbTest Utility in ADHD: A Randomised Controlled Trial
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: OTHER: Qb Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Gastric CLEANsing by Intravenous AZithromycin in Urgent Endoscopy
Status: RECRUITING
Conditions: Upper Gastrointestinal Bleeding
Interventions: DRUG: Azithromycin|DRUG: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Add-on Salmeterol Versus Montelukast in Arg/Arg-16 Asthmatics
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Montelukast Placebo|DRUG: Salmeterol, Montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Immune Response to COVID-19 Vaccines in Patients With Cancer, Transplant or Cellular Therapy Recipients
Status: RECRUITING
Conditions: Cancer|Hematopoietic System--Cancer|Transplant-Related Cancer|Solid Tumor Malignancy|Hematologic Malignancy|Solid Organ Transplant|Hematopoietic Cell Transplant|Cellular Therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Erector Spinae Plane Block in Renal Transplantation Donors
Status: COMPLETED
Conditions: Renal Transplantation|Laparoscopic Nephrectomy|Erector Spinae Plane Block
Interventions: PROCEDURE: Erector Spinae Plane Block|PROCEDURE: Intravenous fentanyl patient control device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial to Evaluate the Efficacy of a Digital Intervention for Patients With Type 2 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus Type 2
Interventions: BEHAVIORAL: Adhera® Fatigue Digital Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visual Outcomes After Implantation of a New Multifocal Intraocular Lens
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Multifocal Intraocular Lens (RAYNER M-FLEX T TORIC IOL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REGENESIS (CA): A Study of NTx™-265: Human Chorionic Gonadotropin (hCG) and Epoetin Alfa (EPO) in Acute Ischemic Stroke Patients
Status: TERMINATED
Conditions: Stroke
Interventions: DRUG: NTx™-265: rhCG, then rEPO|DRUG: Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Evinacumab (REGN1500) in Caucasian and in Japanese Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Evinacumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
Status: RECRUITING
Conditions: Locally Advanced Solid Tumors|Metastatic Solid Tumors
Interventions: DRUG: Oral repotrectinib (TPX-0005)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transforming Primary Care Payment in Hawaii
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes
Interventions: BEHAVIORAL: New Payment Model|BEHAVIORAL: Social Comparisons|BEHAVIORAL: A1c Member/Provider Incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Optimizing the Consent Process for Emergent Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Consent|Laparoscopic|Cholecystectomy
Interventions: BEHAVIORAL: Consent process with the addition of Digital educational platform (DEP)|BEHAVIORAL: Consent process using the standard verbal consent (SVC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics of Atazanavir/Ritonavir in HIV-1 Infected Pregnant Women
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: Atazanavir + Ritonavir + Combivir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Half-Dose Depot Triptorelin Versus Reduced-Dose Daily Buserelin
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Half-Dose Depot Triptorelin|DRUG: Reduced-Dose Daily Buserelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Falls With Fracture : Role of Cognitive Disorders and Comparison With Bone Fragility
Status: COMPLETED
Conditions: Accidental Falls|Fractures
Interventions: BEHAVIORAL: gait and cognitive assessments|BIOLOGICAL: blood sample|OTHER: osteodensitometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cemiplimab in High Risk or Locally Advanced Hormone Receptor Positive HER2 Negative or Triple-Negative Breast Cancer
Status: RECRUITING
Conditions: Invasive Breast Cancer
Interventions: DRUG: Cemiplimab|DRUG: Paclitaxel|DRUG: Carboplatin (not mandatory)|DRUG: Doxorubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Getting Out of the House: Using Behavioral Activation to Increase Community Participation
Status: RECRUITING
Conditions: Major Depressive Disorder|Schizo Affective Disorder|Schizophrenia|Bipolar Disorder
Interventions: BEHAVIORAL: Behavior Activation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7) Water, Sanitation, and Hygiene (WASH) Case Area Targeted Intervention (CATI)
Status: RECRUITING
Conditions: Cholera|Diarrhea
Interventions: BEHAVIORAL: Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7) CATI|BEHAVIORAL: Standard message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Surviving Rectal Cancer at the Cost of a Colostomy International Validation of the Colostomy Impact Score
Status: UNKNOWN
Conditions: Rectal Neoplasms|Quality of Life|Colostomy Stoma
Interventions: OTHER: Questionnaires on HRQoL and sociodemography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Safety, Tolerability and Efficacy of PBKR03 in Pediatric Subjects With Early Infantile Krabbe Disease
Status: SUSPENDED
Conditions: Leukodystrophy, Globoid Cell
Interventions: BIOLOGICAL: PBKR03
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction of Clinical Response Using Rifaximin in Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: Placebo Comparator|DRUG: Rifaximin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of IV/PO Acetaminophen in the Perioperative Period in Reducing Opiate Use After Lumbar Spine Fusion
Status: TERMINATED
Conditions: Fusion of Spine, Lumbar Region
Interventions: DRUG: Acetaminophen IV Soln 10 MG/ML|DRUG: Acetaminophen|DRUG: Hydromorphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Biomarker Study to Identify Predictive Signatures of Response to LDE225 (Hedgehog Inhibitor) In Patients With Resectable Pancreatic Cancer
Status: WITHDRAWN
Conditions: Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: LDE225
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Doravirine/Islatravir (DOR/ISL) in Heavily Treatment-Experienced (HTE) Participants for Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-019)
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: ISL|DRUG: DOR|DRUG: DOR/ISL|DRUG: Placebo to ISL|DRUG: Placebo to DOR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Long-Term Extension Study of WA22763 and NA25220 of Subcutaneous RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a pd VWF/FVIII Concentrate, Biostate®, in Subjects With Von Willebrand Disease
Status: COMPLETED
Conditions: Von Willebrand Disease
Interventions: BIOLOGICAL: Biostate®|BIOLOGICAL: Biostate®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of mFOLFOX-6 Plus Cetuximab for 8 Cycles Followed by mFOLFOX-6 Plus Cetuximab or Single Agent Cetuximab as Maintenance Therapy in Patients With Metastatic Colorectal Cancer and WT KRAS Tumours
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: mFOLFOX-6 + cetuximab until disease progression or early withdrawal.|DRUG: 8 cycles of mFOLFOX-6 + cetuximab, followed by cetuximab alone until disease progression or early withdrawal.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Exparel Adductor Canal Field Block for Pain Control After ACL Reconstruction
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Tear|Pain, Postoperative|Opioid Use
Interventions: DRUG: Liposomal bupivacaine|DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Labeled Exploratory Study to Evaluate Safety and Efficacy of FB825 in Adults With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: FB825, FB825-15D11, Anti-CemX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Frequency Chest Wall Oscillation in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: HFCWO - SmartVest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Multi-intervention Programme for the Elderly
Status: RECRUITING
Conditions: Sarcopenia|Sarcopenic Obesity|Dementia
Interventions: DIETARY_SUPPLEMENT: protein supplementation|BEHAVIORAL: muscle strength training|OTHER: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Interferon Gamma-1b by Inhalation for the Treatment of Patients With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: interferon gamma-1b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Antibiotics Versus Placebo to Treat Antenatal Hydronephrosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Hydronephrosis|Urinary Tract Infection
Interventions: DRUG: Trimethoprim|OTHER: Simple Syrup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Budesonide Effervescent Tablets vs. Viscous Budesonide Suspension vs. Placebo in Eosinophilic Esophagitis
Status: COMPLETED
Conditions: Eosinophilic Esophagitis
Interventions: DRUG: low dose budesonide tablet|DRUG: high dose budesonide tablet|DRUG: high dose budesonide suspension|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical L. Reuteri in Children With Atopic Dermatitis
Status: UNKNOWN
Conditions: Atopic Dermatitis
Interventions: OTHER: Topical L. reeuteri
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Trial to Study the Safety and Effectiveness of MK0826 and Other Antibiotic Therapy in Patients With Complicated Urinary Tract Infection (0826-054)
Status: TERMINATED
Conditions: Urinary Tract Infections
Interventions: DRUG: MK0826 (ertapenem)|DRUG: Comparator: meropenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Ascending Dose Study of R1671 in Patients With Mild Intermittent Asymptomatic Asthma.
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: RG1671
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Deep Gray Matter Anatomic Changes in RRMS Patients Treated With Gilenya® With and Without Cognitive Impairment Over a 2 Year Period Using NeuroQuant, NeuroQuarc and ANAM
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: OTHER: NeuroQuant|OTHER: Automated Neuropsychological Assessment Matrices|OTHER: EDSS|OTHER: Physical Examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vagal Nerve Stimulation and Pain Frequency, Intensity in Chronic Migraine
Status: RECRUITING
Conditions: Migraine
Interventions: DEVICE: Vagal nerve stimulation|DEVICE: Sham vagal nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo Effects in the Treatment of Depression: Cognitive and Neural Mechanisms
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Citalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blue Laser -5ala Photodynamic Therapy (PDT) in High-Risk Non-muscle Invasive Bladder Cancer (NMIBC) Patients
Status: UNKNOWN
Conditions: Non-muscle-invasive Bladder Cancer
Interventions: DRUG: Standard infusion chemotherapy|PROCEDURE: BL - 5 ala PDT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of AG-348 in Adult Participants With Pyruvate Kinase (PK) Deficiency
Status: ACTIVE_NOT_RECRUITING
Conditions: Pyruvate Kinase Deficiency
Interventions: DRUG: AG-348
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Targeted Notification and Clinical Support Pathway on Individuals With Left Ventricular Hypertrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertrophy, Left Ventricular|Hypertension|Cardiomyopathies
Interventions: OTHER: Intervention: Population Health Coordinator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Delivery and Effects of THC Vaping Liquids in the Bloodstream
Status: NOT_YET_RECRUITING
Conditions: Cannabis Dependence
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Cannabis sativa Extract|DRUG: Nicotine|DRUG: Placebo Administration|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Study of Soy Isoflavones in Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Soy isoflavone supplement|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Neoadjuvant Chemotherapy With or Without Camrelizumab for Locally Advanced Gastric Cancer
Status: SUSPENDED
Conditions: Gastric Cancer
Interventions: DRUG: camrelizumab+chemotherapy|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Allogenic Adoptive Immune Therapy for Immune Reconstitution in Chronic HIV-1 Infected Patients
Status: UNKNOWN
Conditions: Human Immunodeficiency Virus|Disorder of Immune Reconstitution
Interventions: COMBINATION_PRODUCT: Conventional plus AAIT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2b Study of Icosabutate in Fatty Liver Disease
Status: COMPLETED
Conditions: Non Alcoholic Steatohepatitis (NASH)
Interventions: DRUG: Icosabutate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anlotinib Combined With Docetaxel for Advanced Non-squamous Non-Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Anlotinib Hydrochloride plus Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Metoprolol Versus Intravenous Amiodarone in the Prevention of Atrial Fibrillation After Cardiac Surgery
Status: COMPLETED
Conditions: Atrial Fibrillation|Cardiac Surgery
Interventions: DRUG: metoprolol, amiodarone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Inclisiran in Participants With Renal Impairment Compared to Participants With Normal Renal Function (ORION-7)
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Inclisiran
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Traditional Chinese Medicine, Western Medicine and Low-level Light Therapy（LLLT） for Primary Dysmenorrhea（PD）
Status: UNKNOWN
Conditions: Primary Dysmenorrhea|Traditional Chinese Medicine|Light
Interventions: DEVICE: low level light therapy|DRUG: DING KUN DAN|DRUG: Simulated drug of DING KUN DAN|DRUG: Marvelon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 13vPnC Multidose Vial Safety, Tolerability and Immunogenicity Study in Healthy Infants.
Status: COMPLETED
Conditions: Pneumococcal Vaccines
Interventions: BIOLOGICAL: 13-valent pneumococcal conjugate vaccine|BIOLOGICAL: 13-valent pneumococcal conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 1 of 7)
Status: COMPLETED
Conditions: Exposure to Man-made Visible Light
Interventions: OTHER: Visible light exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Efficacy, Safety, and Tolerability of CAT-354 in Subjects With Asthma
Status: TERMINATED
Conditions: Asthma
Interventions: OTHER: Placebo|BIOLOGICAL: CAT-354 1 mg/kg|BIOLOGICAL: CAT-354 5 mg/kg|OTHER: CAT-354 10 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Extra Virgin Olive Oil (EVOO) With Health Properties in Metabolic Syndrome
Status: RECRUITING
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: EVOO polyphenols enriched|DIETARY_SUPPLEMENT: EVOO standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: VENLID: The Application of a 10%-Lidocaine Spray Prior to the Insertion of a Peripheral Intra-venous Catheter in Female Adults
Status: NOT_YET_RECRUITING
Conditions: Pain
Interventions: DRUG: Xylocaine 10% pump spray|DRUG: Saline solution isotonic 0.9% NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Assess The Efficacy And Safety Of Dutasteride 0.5mg Once Daily For 6 Months In The Treatment Of Male Subjects With Androgenetic Alopecia
Status: COMPLETED
Conditions: Alopecia
Interventions: DRUG: Dutasteride 0.5mg oral tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Combined General/Epidural Anesthesia Versus General Anesthesia on Diaphragmatic Function
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: epidural 250mL of 0.2% ropivacaine and 2 μg/mL of fentanyl, 5 mL/hr continuous infusion and 0.5 mL bolus dose|DRUG: no epidural drug administered
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety of MEDI-559 in Healthy 1 to <24 Month-Old Children
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: MEDI-559|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nature Video to Improve Older Adult Health: A Feasibility Study.
Status: TERMINATED
Conditions: Mild Dementia|Mild Cognitive Impairment
Interventions: OTHER: Immersive Nature Video|OTHER: Neutral Video
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Laser Therapy in the Rehabilitation of Hemiplegic Patients From Ischemic Stroke
Status: TERMINATED
Conditions: Hemiplegia
Interventions: PROCEDURE: low level laser therapy procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The RAD-HOME Project: a Pilot Study of Domiciliary Teleradiology
Status: COMPLETED
Conditions: Acute Congestive Heart Failure|Exacerbation of COPD|Pneumonia|Fractures|Osteomyelitis
Interventions: RADIATION: Home X-rays|RADIATION: X-rays in hospital
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Double-blind Sitagliptin Add-on Study in Japanese Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Ipragliflozin (MK-0431J-842)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin|DRUG: Placebo|DRUG: Ipragliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of KCT-0809 in Patients With Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: KCT-0809|DRUG: KCT-0809|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Qutenza Versus Duloxetine in Chemotherapy-induced Peripheral Neuropathy (CIPN)
Status: RECRUITING
Conditions: Qutenza|Duloxetine|Chemotherapy-induced Peripheral Neuropathy|CIPN - Chemotherapy-Induced Peripheral Neuropathy
Interventions: DRUG: Qutenza|DRUG: Duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 52 Week Trial of Liraglutide in Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Liraglutide|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety and Tolerability of Combined Administration of SHR2285 Tablets With Aspirin, Clopidogrel or Ticagrelor in Healthy Subjects
Status: COMPLETED
Conditions: Thrombosis
Interventions: DRUG: Aspirin、clopidogrel、placebo or SHR2285|DRUG: Aspirin、clopidogrel、placebo or SHR2285|DRUG: Aspirin、ticagrelor、placebo or SHR2285
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Impact of Virtual Reality Distraction on Pain and Anxiety for Bedside Abdominal VAC Dressing Change
Status: COMPLETED
Conditions: Pain|Anxiety|Satisfaction, Patient
Interventions: DEVICE: VRD in addition to standardized analgesic protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Natural Killer-cell Therapy for Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia Refractory|Acute Myeloid Leukemia, Relapsed, Adult
Interventions: BIOLOGICAL: UCB-NK cells|DRUG: IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Support in Primary Care for People Starting Treatment for Cancer
Status: COMPLETED
Conditions: Cancer of Pancreas|Cancer of Stomach|Cancer of Esophagus
Interventions: OTHER: Anticipatory care planning letter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Eccentric Training Intervention in Older Adults
Status: UNKNOWN
Conditions: Sarcopenia
Interventions: DEVICE: Eccentric exercise|DEVICE: Conventional resistance exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Study in Participants With Huntington's Disease (HD) to Assess Efficacy and Safety of Three Oral Doses of Laquinimod
Status: COMPLETED
Conditions: Huntington's Disease
Interventions: DRUG: Laquinimod|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-center, Pediatric, Open-label, Preference Study of Desloratadine 2.5 mg Reditab (SCH34117) and Zyrtec 5.0 mg Chewable Tablet Medications (Study P04574)(COMPLETED)
Status: COMPLETED
Conditions: Allergies
Interventions: DRUG: Desloratadine|DRUG: Zyrtec® (cetirizine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Milk and Soured Milk (filmjölk) Intervention on Oxidative Stress and Inflammation
Status: COMPLETED
Conditions: Oxidative Stress|Inflammation
Interventions: OTHER: Milk|OTHER: Soured milk (filmjölk)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety Study to Evaluate MN-221 in Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: MN-221|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Medial Wedge Insoles to Improve Gait in Persons After Total Hip Replacement
Status: NOT_YET_RECRUITING
Conditions: Arthritis of Hip|Fracture of Femur|Aseptic Necrosis|Dysplasia; Hip|Surgical Procedure, Unspecified
Interventions: DEVICE: medial wedge insoles ((corrective insoles are equipped with hard 10-degree medial wedge, while sham insoles are equipped with pliable 10-degree medial wedge)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Goal-directed Hemodynamic Therapy Driven by ECOM on Morbidity and Mortality After Cardiac Surgery?
Status: COMPLETED
Conditions: Coronary Surgery With Cardiopulmonary Bypass
Interventions: BEHAVIORAL: hemodynamic optimization strategy driven by the ECOM|BEHAVIORAL: standard management strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Propranolol and Von Hippel-Lindau Disease
Status: RECRUITING
Conditions: Hemangioblastoma of CNS|Von Hippel-Lindau Disease
Interventions: DRUG: Propranolol|OTHER: follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-line Therapy in Metastatic PDAC
Status: UNKNOWN
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Nab-paclitaxel|DRUG: 5-FU|DRUG: Irinotecan Liposomal Injection|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Long-Term Safety of Pharmaceutical Grade Synthetic Cannabidiol Oral Solution in Participants With Prader-Willi Syndrome
Status: TERMINATED
Conditions: Prader-Willi Syndrome
Interventions: DRUG: Cannabidiol Oral Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MEND-CABG (MC-1 to Eliminate Necrosis and Damage in Coronary Artery Bypass Graft Surgery)
Status: COMPLETED
Conditions: Coronary Artery Bypass Graft Surgery|Myocardial Ischemia|Reperfusion Injury|Myocardial Revascularization
Interventions: DRUG: (MC-1) Pyridoxal-5'-phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Urban Gardening and Peer Nutritional Counseling for People With HIV and Food Insecurity
Status: RECRUITING
Conditions: HIV|Food Insecurity
Interventions: BEHAVIORAL: Peer Nutritional Counseling + Urban Gardening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Efficacy Of Rhinophototherapy Compared To Intranasal Corticosteroids On The Nasal Mucosa
Status: RECRUITING
Conditions: Allergic Rhinitis
Interventions: DEVICE: Rhinophototherapy|DRUG: Nasonex Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Iron Absorption From an Iron-fortified Follow-up Formula With Added Synbiotic or Human Milk Oligosaccharides
Status: COMPLETED
Conditions: Iron Absorption
Interventions: OTHER: Test formula A without added pre- and pro-biotic|OTHER: Test formula B with synbiotic|OTHER: Test formula C with HMOs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effect of Total Cold Water Immersion Vs Ice Massage Modalities
Status: COMPLETED
Conditions: Exercise-induced Muscle Damage
Interventions: OTHER: Total cold-water immersion|OTHER: Ice massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Remifentanil vs Fentanyl During Cardiac Surgery and Chronic Thoracic Pain
Status: COMPLETED
Conditions: Chronic Pain|Sternotomy|Remifentanil|Fentanyl
Interventions: DRUG: Fentanyl|DRUG: Remifentanil|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetic Study of Busulfan in Allogeneic Stem Cell Transplantation in Adult Patients With Acute Leukemia
Status: UNKNOWN
Conditions: Acute Leukemia
Interventions: DRUG: Busulfan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Bioequivalence of 70 mg Alendronate and 70 mg Alendronate in Combination With 2800 IU Vitamin D
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: alendronate sodium (+) cholecalciferol|DRUG: Comparator: alendronate|DIETARY_SUPPLEMENT: Comparator: cholecalciferol (Vitamin D)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment According to Venous Excess Ultrasound Score in Patients With Heart Failure
Status: NOT_YET_RECRUITING
Conditions: Heart Failure|Acute Kidney Injury
Interventions: OTHER: VEXUS score|DIAGNOSTIC_TEST: NGAL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics and Preliminary Efficacy Study of CFZ533 in Patients With Lupus Nephritis.
Status: COMPLETED
Conditions: Lupus Nephritis
Interventions: DRUG: CFZ533|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pforzheim Tricuspid Valve Registry - Outcomes of Percutaneous Tricuspid Valve Repair
Status: RECRUITING
Conditions: Tricuspid Regurgitation|Right Heart Failure|Cardiac Remodeling, Ventricular|Cardiac Remodeling, Atrial
Interventions: PROCEDURE: Transcatheter edge-to-edge tricuspid valve repair
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CXCL2/CXCL8 Promote Intervertebral Disc Degeneration
Status: RECRUITING
Conditions: Cytokine|Intervertebral Disc, Degenerative
Interventions: DIAGNOSTIC_TEST: CXCL2/CXCL8
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Evaluation of Etafilcon A Contact Lenses Using a Novel Molding Process 2
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: etafilcon A with novel molding process|DEVICE: etafilcon A with current molding process
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Active Breathing Exercises in Stroke Patients With Respiratory Rhythm Disorder
Status: NOT_YET_RECRUITING
Conditions: Respiratory Rhythm Disorder
Interventions: BEHAVIORAL: Rehabilitation training|BIOLOGICAL: Active Breathing Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Asthma In-Home Monitoring (AIM) Trial
Status: UNKNOWN
Conditions: Mild, Moderate and Severe Persistent Asthma as Defined by NHLBI-2 Guidelines
Interventions: PROCEDURE: In-home telemonitoring of pediatric patients with persistent asthma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: ECT
Clinical trial: To Evaluate Whether Acetyl Salicylic Acid (Aspirin), the Combination of Aspirin and Clopidogrel and Darexaban (YM150) Interact in Their Effects
Status: COMPLETED
Conditions: Pharmacodynamic Interaction|Healthy Subjects
Interventions: DRUG: darexaban|DRUG: darexaban (double dose)|DRUG: Acetyl Salicylic Acid|DRUG: clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Treatment of Severely Obese Children and Adolescents Employing "Family-based Behavioral Social Facilitation Treatment"
Status: COMPLETED
Conditions: Childhood Obesity
Interventions: BEHAVIORAL: Family-based behavioral social facilitation therapy|BEHAVIORAL: TAU - Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Absorbance Values, Sensory Evaluations and Periodontal Effects of Five Different Products for Clean Aligners Cleansing
Status: COMPLETED
Conditions: Dental Malocclusion
Interventions: OTHER: Aligners cleansing with water|OTHER: Aligners cleansing with dish soap Svelto|OTHER: Aligners cleansing with Polident Antibacterial Denture Cleaner|OTHER: Aligners cleansing with Invisalign Cleaning Crystals|OTHER: Aligners cleansing with Geldis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of HMG-CoA Reductase Inhibitors on the Meibomian Gland Morphology in Patients With Meibomitis
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction|Meibomitis|Dyslipidemias
Interventions: DEVICE: Keratograph 5M, Oculus, Wetzlar, Germany
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Pharmacokinetic of Donepezil Pamoate in Healthy Subjects
Status: COMPLETED
Conditions: AD
Interventions: DRUG: Donepezil Pamoate for Injection 17mg|DRUG: Donepezil Pamoate for Injection 34mg|DRUG: Donepezil Hydrochloride 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rectal Indomethacin in the Prevention of Post-ERCP Pancreatitis
Status: COMPLETED
Conditions: Post-ERCP Pancreatitis
Interventions: DRUG: high dose indomethacin|DRUG: standard dose indomethacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Evaluate The Effects Of SB-649868 (10, 30 Mg And 60 Mg) On Subjects With Primary Insomnia
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders
Interventions: DRUG: SB-649868|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neuroprotective Effects of Lithium in Patients With Small Cell Lung Cancer Undergoing Radiation Therapy to the Brain
Status: COMPLETED
Conditions: Small Cell Lung Carcinoma
Interventions: DRUG: Lithium Carbonate|RADIATION: Prophylactic cranial irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Protein and Alkali Supplementation on Skeletal Muscle in Older Adults
Status: COMPLETED
Conditions: Age-Related Sarcopenia|Muscle Loss
Interventions: DIETARY_SUPPLEMENT: whey protein isolate|DIETARY_SUPPLEMENT: potassium bicarbonate (KHCO3)|OTHER: microcrystalline cellulose|OTHER: maltodextrin powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Breastfeeding Education in the Time of COVID-19
Status: COMPLETED
Conditions: Breastfeeding|Breastfeeding, Exclusive|Breastfeeding Jaundice|Educational Problems
Interventions: BEHAVIORAL: Telesimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Management Of Large Incisional Hernia, Double Mesh Modification Of Chevrel's Technique Versus On Lay Mesh Hernioplasty
Status: COMPLETED
Conditions: Hernia Incisional Ventral
Interventions: PROCEDURE: double mesh modification of chevrel's technique|PROCEDURE: on lay mesh hernioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders
Status: COMPLETED
Conditions: Schizo-affective Disorder|Bipolar Disorder
Interventions: DRUG: Glycine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inflammation and Coagulation Factors for Predicting Cerebral Edema After SAH
Status: RECRUITING
Conditions: Inflammation|Coagulation and Hemorrhagic Disorders|Cerebral Edema
Interventions: DIAGNOSTIC_TEST: Inflammatory factors and coagulation factors level in cerebrospinal fluid after subarachnoid hemorrhage
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Decreasing Post-Operative Nausea and Vomiting in the Bariatric Surgical Patient
Status: RECRUITING
Conditions: Nausea, Postoperative|Vomiting, Postoperative
Interventions: OTHER: nausea relief inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Exploratory Study to Assess the Short Term Effect on Liver Enzymes and the Safety of TRO19622 in Patients With Non-Alcoholic Steatohepatitis (NASH)
Status: COMPLETED
Conditions: Non-Alcoholic Steatohepatitis (NASH)
Interventions: DRUG: TRO19622
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Extension Trial to Evaluate the Long-term Safety of KVD900 for On-Demand Treatment of Angioedema Attacks in Adolescent and Adult Patients With Hereditary Angioedema (HAE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Hereditary Angioedema
Interventions: DRUG: KVD900 600 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project REST: Regulation of Eating and Sleep Topography
Status: RECRUITING
Conditions: Obesity, Childhood|Binge Eating|Sleep|Self-regulation
Interventions: BEHAVIORAL: Sleep restriction|BEHAVIORAL: Sleep extension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dose-finding, Safety, Efficacy Trial of Topical Resiquimod in Patients With Multiple Actinic Keratosis Lesions
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Resiquimod 0.03%|DRUG: Resiquimod 0.01%|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT