pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Nurse-led Exercise Improves Shoulder Pain, Shoulder Disability, and Quality of Life in Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer|Cancer of Head and Neck|Head and Neck Neoplasms
Interventions: BEHAVIORAL: nurse-led counseling and after intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Meaning-based Group Counselling for Bereavement
Status: COMPLETED
Conditions: Grief|Bereavement
Interventions: BEHAVIORAL: Meaning-Based Bereavement Group|BEHAVIORAL: Conventional Bereavement Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hydronidone for the Treatment of Liver Fibrosis Associated With Chronic Viral Hepatitis B Phase 3 Trial.
Status: RECRUITING
Conditions: Liver Fibrosis
Interventions: DRUG: Hydronidone capsules|DRUG: The placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Qigong vs. Physiotherapy to Improve Quality of Life of Women With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: OTHER: Qigong group|OTHER: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Electronic Brief Alcohol Intervention for Women Attending a Breast Screening Service (Health4Her)
Status: COMPLETED
Conditions: Health Knowledge, Attitudes, Practice|Alcohol Drinking
Interventions: BEHAVIORAL: Brief alcohol intervention (Health4Her-Automated)|BEHAVIORAL: Lifestyle health promotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of a Traditional Chinese Exercise Program on Symptom Cluster in Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Neoplasm Female|Symptom Cluster|Tai ji
Interventions: OTHER: control group|BEHAVIORAL: tai chi group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Low-level Laser Therapy on Palatal Wound Healing
Status: COMPLETED
Conditions: Palatal Wound
Interventions: PROCEDURE: LLLT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Aim of This Investigation is to Compare the Influence of 0.9% Saline and Plasmalyte Solution on Acid-base Balance and Electrolytes in Healthy Patients Undergoing Major Spine Surgeries.
Status: COMPLETED
Conditions: Spinal Surgery
Interventions: OTHER: 0.9% normal saline|OTHER: plasmalyte
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Simvastatin as an add-on Treatment to Copaxone for the Treatment of Relapsing Multiple Sclerosis
Status: WITHDRAWN
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: Simvastatin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Dextrose Infusion and Postoperative Nausea and Vomiting
Status: NOT_YET_RECRUITING
Conditions: Effect of Dextrose on Postoperative Nausea and Vomiting
Interventions: OTHER: group d|OTHER: group R
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact if Desflurane Preconditioning on the Content of the Phospho-GSK-3b in the Rat's Neurons in the Model of I/R
Status: WITHDRAWN
Conditions: Heart Arrest
Interventions: DRUG: Desflurane|DRUG: Sevoflurane|PROCEDURE: Cardiac arrest
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Safety and Efficiency of the Use of Neutral Argon Plasma in Cyto-reduction of Miliary Implants in the Peritoneal Surface.
Status: COMPLETED
Conditions: Peritoneal Carcinomatosis
Interventions: DEVICE: Use of plasma of neutral argon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Eplerenone Versus Spironolactone in Heart Failure Patients With Glucose Intolerance or Type 2 Diabetes
Status: COMPLETED
Conditions: Heart Failure|Type 2 Diabetes|Glucose Intolerance
Interventions: DRUG: Eplerenone|DRUG: Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ADASUVE-Lorazepam Drug-Drug Interaction
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Lorazepam 1 mg IM|DRUG: Inhaled loxapine 10 mg|DRUG: Inhaled Placebo|DRUG: Placebo IM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Immunotherapy With Depigmented and Polymerized Allergen Extract of Olea Europaea (GPIT)
Status: COMPLETED
Conditions: Allergy|Rhinoconjunctivitis
Interventions: BIOLOGICAL: Immunotherapy with modified extract of O. europaea pollen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy
Status: UNKNOWN
Conditions: Elective Laproscopic Bilateral Inguinal Hernia|Elective Laproscopic Cholecystectomy
Interventions: DRUG: Oxycodone 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Trilogy Stereotactic Body Radiotherapy for Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: RADIATION: Stereotactic Body Radiotherapy|DRUG: Gemcitabine|OTHER: 4D pancreatic protocol CT scan|RADIATION: FDG PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CyclASol for the Treatment of Signs and Symptoms of Dry Eye Disease in Subjects Who Completed CYS-004
Status: COMPLETED
Conditions: Dry Eye Disease (DED)
Interventions: DRUG: CyclASol Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UCN-01 and Irinotecan in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: 7-hydroxystaurosporine|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety of the Etonogestrel-releasing Implant During the Puerperium of Healthy Women
Status: COMPLETED
Conditions: Breastfeeding|Contraception
Interventions: DRUG: etonogestrel implant|DRUG: depot medroxyprogesterone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Immune Memory of DTPw-HBV/Hib Vaccine Following Primary Vaccination, Immuno & Reacto of a Booster Dose Given in Infants
Status: COMPLETED
Conditions: Whole Cell Pertussis|Diphtheria|Hepatitis B|Tetanus|Haemophilus Influenzae Type b
Interventions: BIOLOGICAL: Tritanrix™-HepB/Hiberix™ Kft.|BIOLOGICAL: Tritanrix™-HepB/Hiberix™|BIOLOGICAL: Hiberix™|BIOLOGICAL: Polyribosil-Ribitol-Phosphate (PRP) vaccine|BIOLOGICAL: Tritanrix™-HepB Kft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Physical Exercise in Postoperative Bariatric Surgery Patients
Status: SUSPENDED
Conditions: Physical Exercise|Bariatric Surgery|Morbid Obesity
Interventions: OTHER: Physical Exercise|OTHER: High-intensity interval training performed at cycle ergometer.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dipeptidyl Peptidase-4 Link With Oral Cancer and Premalignant Lesions
Status: COMPLETED
Conditions: Oral Premalignant Lesions as Leukoplakia and Lichen Planus|Oral Cancer
Interventions: DIAGNOSTIC_TEST: serum and unstimulated salivary samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Electroencephalographic Effects of Spinal Anaesthesia During Caesarean Delivery in Preeclampsia
Status: UNKNOWN
Conditions: Pre-Eclampsia|Effects of; Anesthesia, Spinal and Epidural, in Pregnancy
Interventions: DEVICE: EEG measure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evidence-based Laboratory Test Order Sets in Primary Care
Status: COMPLETED
Conditions: Diabetes Mellitus|Hypertension|Cardiovascular Diseases|Fatigue|Anemia|Liver Diseases|Medication Monitoring|Gout|Chronic Kidney Diseases|Lung Embolism|Acute Coronary Syndrome|Diarrhea|Thyroid Diseases|Sexually Transmitted Diseases|Rheumatoid Arthritis|Obesity|General Check-up
Interventions: OTHER: CPOE with order sets for lab testing|OTHER: CPOE without order sets for lab testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Anti-Freaze-F Study- "Anti-TNF for Treatment of Frozen Shoulder - a Feasibility Study"
Status: COMPLETED
Conditions: Frozen Shoulder
Interventions: DRUG: Adalimumab Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CO-Rebreathing in Comparison to Isotopic Red Cell Volume Determination in the Diagnosis of Primitive and Secondary Polycythemia
Status: COMPLETED
Conditions: Polycythemia
Interventions: OTHER: CO-Rebreathing technique at diagnosis of polycythemia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intermittent Hypoxia Paired With High Intensity Training in Brain Injury
Status: COMPLETED
Conditions: Brain Injuries
Interventions: PROCEDURE: Intermittent hypoxia|PROCEDURE: Sham hypoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study Of CPX-1 (Irinotecan HCl: Floxuridine) Liposome Injection In Patients With Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: DRUG: CPX-1 (Irinotecan HCl:Floxuridine) Liposome Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between ex Vivo and in Vivo Injection of Blue Dye in Sentinel Lymph Node Mapping for Colon Cancer
Status: UNKNOWN
Conditions: Sentinel Lymph Node Biopsy|Colon Cancer
Interventions: PROCEDURE: Intraoperative injection (in vivo)|PROCEDURE: Postoperative injection (ex vivo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: A Study of Atezolizumab (an Engineered Anti-Programmed Death-Ligand 1 [PDL1] Antibody) to Evaluate Safety, Tolerability and Pharmacokinetics in Participants With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Tumors|Hematologic Malignancies
Interventions: DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment With Tucatinib in Patients With an Isolated Brain Progression of a Metastatic Breast Cancer
Status: RECRUITING
Conditions: Metastatic Breast Cancer With a Isolated Brain Progression
Interventions: DRUG: Tucatinib|DRUG: Pertuzumab|DRUG: Trastuzumab|DRUG: Hormone therapy|DRUG: Pertuzumab/ Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Place of the Video-laryngoscope in Learning Intubation by Simulation
Status: COMPLETED
Conditions: Airway Management|Intubation, Intratracheal|Simulation|Laryngoscopy
Interventions: DEVICE: Videolaryngoscope first|DEVICE: Direct laryngoscope first
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Avastin for PDR (Proliferative Diabetic Retinopathy)
Status: COMPLETED
Conditions: Retinal Detachment|Diabetic Retinopathy
Interventions: DRUG: Avastin (bevacizumab)|OTHER: Sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of the da Vinci Surgical System
Status: ACTIVE_NOT_RECRUITING
Conditions: Thymoma|Mediastinal Tumor|Gynecologic Disease|Gynecologic Cancer|Pelvic Organ Prolapse|Prostate Disease|Prostate Cancer|Inguinal Hernia|Ventral Hernia|Obesity, Morbid
Interventions: DEVICE: Robotic-assisted Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Cancer Therapies and Exercise on Mitochondrial Energetics and Fitness
Status: COMPLETED
Conditions: Locally Advanced Rectal Cancer
Interventions: PROCEDURE: Structured responsive interval exercise training programme|OTHER: Sham group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of a Multimodal Intervention on Peripheral Venous Catheterization of Cancer Patients
Status: COMPLETED
Conditions: Catheterization, Peripheral
Interventions: DEVICE: PIVC pack
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Surgical Treatment After Neoadjuvant Chemotherapy Plus Intraperitoneal Immunotherapy Versus Chemotherapy Alone for Patients With Positive Wash Cytology Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer, Metastatic
Interventions: PROCEDURE: neoadjuvant chemoimmunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Radiation Therapy With Ifosfamide in Patients With Mixed Mesodermal Tumors of the Uterus
Status: COMPLETED
Conditions: Uterine Cancer
Interventions: DRUG: Ifosfamide|DEVICE: Radiation Therapy|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EdOxaban in fRagIle Patients With Percutaneous Endoscopic GAstrostoMy and atrIal fIbrIllation
Status: RECRUITING
Conditions: Atrial Fibrillation|Fragility
Interventions: DRUG: Edoxaban|DRUG: No Edoxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of BG-C9074 as Monotherapy and in Combination With Tislelizumab in Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: BG-C9074|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Comparison Between Traditional Laparoscopy-assisted Surgery and NOSES in Radical Resection of Colorectal Cancer
Status: UNKNOWN
Conditions: Laparoscopy-assisted Surgery|Total Laparoscopic Surgery With no Incision (Natural Orifice Transluminal Endoscopic Surgery, NOSES)
Interventions: PROCEDURE: traditional laparoscopy-assisted surgery|PROCEDURE: total laparoscopic surgery with no incision (natural orifice transluminal endoscopic surgery, NOSES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Immersive Virtual Reality to Treat Complex Regional Pain Syndrome in Adults
Status: RECRUITING
Conditions: Pain, Chronic
Interventions: BEHAVIORAL: in clinic pain VR reduction exercises|BEHAVIORAL: In clinic VRpain reduction exercises + VR homeworks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Immobilisation Shells in Cranial Radiotherapy
Status: COMPLETED
Conditions: Brain Metastases|Bone Metastases|Brain Tumor, Primary|Brain Tumor Adult|Brain Tumor - Metastatic
Interventions: DEVICE: Group A: Closed-face shell|DEVICE: Group B: Open-face shell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AlloSure for the Monitoring of Antibody Mediated Processes After Kidney Transplantation
Status: COMPLETED
Conditions: Kidney Transplant Failure and Rejection
Interventions: DIAGNOSTIC_TEST: AlloSure ddcfDNA assay|DIAGNOSTIC_TEST: AlloMap assay|DIAGNOSTIC_TEST: Inflammatory Cytokines|DIAGNOSTIC_TEST: Immune Cell Phenotypes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of a Novel Neural Tissue Management to Improve Short-term Pain and Disability in Patients With Sciatica
Status: COMPLETED
Conditions: Sciatica Pain|Physical Therapy Modalities|Manual Therapies|Disability Evaluation
Interventions: OTHER: Physical therapy treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Mini-dose Glucagon to Prevent Exercise-induced Hypoglycemia in Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: G-Pen Mini™ (glucagon injection)|OTHER: Glucose Tabs|OTHER: Basal Insulin Reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: EGFR-mutated Lung Cancer in Randomized Investigator-Initiated Study
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Afatinib/Dacomitinib|DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Penicillin Against Flucloxacillin Treatment Evaluation
Status: WITHDRAWN
Conditions: Staphylococcus Aureus
Interventions: DRUG: Benzylpenicillin|DRUG: Flucloxacillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Renal Transplantation on Obstructive Sleep Apnea in End Stage Renal Disease Patients (SASinTx)
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Overhydration|End Stage Renal Disease|Renal Transplantation
Interventions: PROCEDURE: Renal transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Bacopa Monniera Extract on Cognition and Anxiety and Exploration of PK Properties
Status: COMPLETED
Conditions: Cognition|Anxiety|Pharmacokinetics
Interventions: DIETARY_SUPPLEMENT: Brahmi|OTHER: Placebo|DIETARY_SUPPLEMENT: Brahmi|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Quality of Life and Self-esteem After Botox® Injections in Depressed and Non-depressed Patients
Status: COMPLETED
Conditions: Depression|Quality of Life
Interventions: DRUG: Botulinum Toxin Type A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HMPL-453 (FGFR Inhibitor) in Combination With Chemotherapy or Anti-PD-1 Antibody in Advanced Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: HMPL-453|DRUG: gemcitabine and cisplatin|DRUG: toripalimab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/IIa Study of Concomitant Radiotherapy With Olaparib and Temozolomide in Unresectable High Grade Gliomas Patients
Status: RECRUITING
Conditions: Malignant Gliomas|Radiotherapy|PARP Inhibitor
Interventions: DRUG: Olaparib|DRUG: Temozolomide (TMZ)|RADIATION: IMRT (Intensity Modulated Radiation Therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tear Film Evaluation of Dailies® AquaComfort Plus® Multifocal and Toric
Status: COMPLETED
Conditions: Refractive Error
Interventions: DEVICE: Nelfilcon A multifocal contact lenses|DEVICE: Nelfilcon A toric contact lenses|DEVICE: Nelfilcon A sphere contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tenon Medical CATAMARAN™ SI Joint Fusion System CT Scan Study
Status: ENROLLING_BY_INVITATION
Conditions: Sacroiliac Joint Disruption|Degenerative Sacroiliitis
Interventions: RADIATION: Pelvic CT Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Added Value of an Internet-based Intervention for Treatment of Forensic Psychiatric Outpatients
Status: RECRUITING
Conditions: Aggression|Psychosocial Problem|Forensic Psychiatry|Internet-based Intervention
Interventions: BEHAVIORAL: Aggression|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Erlotinib in Treating Patients With Recurrent or Metastatic Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity Cancer
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: erlotinib hydrochloride|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Two Corticotomy Techniques in Retracting the Upper Anterior Teeth by Using Miniscrews
Status: COMPLETED
Conditions: Class II Div 1 Malocclusion|Protrusion, Incisor
Interventions: PROCEDURE: Flapless corticotomy surgical intervention will be conducted|PROCEDURE: Traditional corticotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remote Ischemic Preconditioning Before Abdominal Surgery
Status: WITHDRAWN
Conditions: Perioperative/Postoperative Complications
Interventions: PROCEDURE: Remote Ischemic Pre-conditioning|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Comparison of Miniinvasive and Open Pancreaticoduodenectomy for Cancer Pancreaticobiliary Zone
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer|Bile Duct Cancer|Ampulla of Vater Cancer
Interventions: PROCEDURE: pancreaticoduodenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application Circulating Tumor DNA Dynamic Monitoring in Clinical Treatment of Metastatic Renal Cell Carcinoma
Status: RECRUITING
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: sunitinib or pazopanib|DRUG: PD-1 inhibitor combined with axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study Of Neratinib (HKI-272) And Capecitabine In Japanese With Solid Tumor
Status: COMPLETED
Conditions: Advanced Malignant Solid Tumors
Interventions: DRUG: Neratinib|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Helping Parents to Decide Whether They Want to be With Their Child During Anesthesia Induction
Status: COMPLETED
Conditions: Pre-operative Anxiety
Interventions: BEHAVIORAL: Parental presence decision tool|BEHAVIORAL: Standard preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Henagliflozin in Relieving Type 2 Diabetes With Non-alcoholic Fatty Liver Disease
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes|Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: Henagliflozin|OTHER: Background medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Alcoholic Chlorhexidine 2% Versus Alcoholic Povidone Iodine for Infections Prevention With Cardiac Resynchronization Therapy Device Implantation
Status: COMPLETED
Conditions: Heart Failure|Arrhythmia
Interventions: DRUG: alcoholic povidone iodine|DRUG: alcoholic chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Mitoxantrone Hydrochloride Liposome Injection Combination Therapy in Chinese Patients With Advanced Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: Mitoxantrone Hydrochloride Liposome injection|DRUG: Capecitabine|DRUG: Albumin-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Olanzapine in Patients With Acute Agitation
Status: NOT_YET_RECRUITING
Conditions: Acute Agitation
Interventions: DRUG: Olanzapine|DRUG: Haloperidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chronic Kidney Disease and Bone - Correlation Between 18F-PET-TT Imaging and Histomorphometry of Bone in CKD Patients
Status: UNKNOWN
Conditions: Chronic Kidney Disease
Interventions: DEVICE: 18F-PET-TT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Clinical Performance for Recent Non Coated Glass Ionomer in Posterior Teeth
Status: UNKNOWN
Conditions: Occlusal Caries
Interventions: COMBINATION_PRODUCT: Non Coated Glass Ionomer|COMBINATION_PRODUCT: Conventional Glass Ionomer with Coat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physiological and Molecular Influences of Astaxanthin Supplementation on Heat Strain in Humans
Status: UNKNOWN
Conditions: Body Temperature Regulation
Interventions: DRUG: Astaxanthin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immunogenicity and Safety of a Trivalent Inactivated Influenza Vaccine, Formulation 2010-2011, in Healthy Subjects Aged Over 6 Months Old to 18 Years Old
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: AdimFlu-S 2010-2011, inactivated
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Different Vitamin D Supplementation Delivery Methods
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: vitamin D3|DIETARY_SUPPLEMENT: Pill|DIETARY_SUPPLEMENT: orange syrup|OTHER: mineral oil|DIETARY_SUPPLEMENT: Penetrator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Study of Antiplatelet and Anticoagulation Therapy in Hereditary Haemorrhagic Telangiectasia
Status: RECRUITING
Conditions: Hereditary Hemorrhagic Telangiectasia|Rendu Osler Disease
Interventions: OTHER: monitoring the use of anticoagulant and/or antiplatelet therapy in patients with osler rendering disease
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Changes in Subjects With Posterior Capsule Tightness
Status: COMPLETED
Conditions: Shoulder Pain
Interventions: OTHER: Posterior shoulder mobilizations|OTHER: External rotators strengthening|OTHER: Placebo ultrasound|OTHER: Scapular squeezing|OTHER: Upper trapezius stretching|OTHER: Posterior Capsule Stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide and Low-Dose Dexamethasone in Patients With Previously Treated Multiple Myeloma and Kidney Dysfunction
Status: TERMINATED
Conditions: Multiple Myeloma|Plasma Cell Neoplasm
Interventions: DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: Anticoagulants
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Continuous Glucose Monitoring in Subjects With Type 1 Diabetes Mellitus on Multiple Daily Injections (MDI) or Continuous Subcutaneous Insulin Infusion (CSII) Therapy
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: CGM
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Autologous Endothelial Progenitor Cell CD 133 for Therapeutic Angiogenesis
Status: COMPLETED
Conditions: Coronary Artery Disease|Refractory Angina
Interventions: BIOLOGICAL: Selected CD 133+ cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of a New Formulation of Insulin Glargine With Lantus® Both in Combination With Oral Antihyperglycemic Drug(s) in Japanese Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Insulin glargine new formulation (HOE901)|DRUG: Insulin glargine (HOE901)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Dextromethorphan and Memantine in Treating Bipolar Disorder
Status: UNKNOWN
Conditions: Bipolar Disorder II
Interventions: DRUG: Dextromethorphan|DRUG: Memantine|DRUG: dextromethorphan+memantine|DRUG: placebo+valproate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Early Proton Pump Inhibitor Initiation Versus Usual Care on Acute Kidney Injury in Hemorrhagic Shock Patients
Status: NOT_YET_RECRUITING
Conditions: Acute Kidney Injury
Interventions: DRUG: Protonix (Pantoprazole) 40 mg q 12 hrs for 2 days|DRUG: Protonix (pantoprazole) 40 mg q 24 hrs for 2 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Two Electrotherapy Methods on Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain, Mechanical
Interventions: OTHER: Pulse Electromagnetic Field|OTHER: Interferential Current|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study for Treatment With TH-4000 (Tarloxotinib) in Epidermal Growth Factor Receptor (EGFR) Mutant, T790M-negative Non-small Cell Lung Cancer (NSCLC) Patients
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer|NSCLC|Non-squamous NSCLC
Interventions: DRUG: TH-4000 (Tarloxotinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block Versus Paravertebral Block
Status: COMPLETED
Conditions: Breast Cancer|Pain, Postoperative|Anesthesia, Local
Interventions: PROCEDURE: Paravertebral block|PROCEDURE: Erector spinae plane block|DRUG: General anesthetic|DRUG: Opioids|DRUG: Anesthetics, Local
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketogenic Diet and CPAP Previous Bariatric Surgery
Status: COMPLETED
Conditions: Obstructed Sleep Apnea Syndrome in Patient Candidate to Baratric Surgery
Interventions: DEVICE: Cpap and ketogenic diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Retinal Atrophy and Neurofilament Light Chain in People With Multiple Sclerosis Taking Ofatumumab
Status: ENROLLING_BY_INVITATION
Conditions: Multiple Sclerosis|Tomography, Optical Coherence|Retinal Degeneration|Visual Acuity
Interventions: DRUG: Ofatumumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Acute Ischemic Stroke With Rt-PA Combined With Edaravone Dexborneol
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Edaravone dexborneol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Clinical Efficacy of Streptococcus Dentisani CECT 7746 in Caries Risk Reduction
Status: COMPLETED
Conditions: Caries
Interventions: BIOLOGICAL: Probiotic|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immune Response and Safety of HS110 Vaccine in Combination With Erlotinib in Patients With Non-Small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: HS110 vaccine|BIOLOGICAL: Placebo|BIOLOGICAL: HS110 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Evaluation for Failed TAVR
Status: NOT_YET_RECRUITING
Conditions: Symptomatic Patients Who Have Had Transcatheter Heart Valve (THV) Failure|Prosthetic Valve Malfunction|Prosthesis Failure
Interventions: PROCEDURE: TAVR-explant|DEVICE: Redo-TAVR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lamivudine and Adefovir Dipivoxil Fixed Dose Combination
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Lamivudine|DRUG: Adefovir dipivoxil|DRUG: Fixed dose combination (Lamivudine and Adefovir dipivoxil)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evolution of Food Orality in Children Aged Between 24 and 36 Months: Comparison of the Severity and Specificities of Disorders Between Two Populations of Children, Born Very Prematurely and Born at Term
Status: COMPLETED
Conditions: Infant, Premature, Diseases
Interventions: BEHAVIORAL: Archet scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Use of Jet Injection Lidocaine for Blood Draws in Young Children
Status: COMPLETED
Conditions: Pain
Interventions: DEVICE: J tip|OTHER: Pain Ease Spray|DRUG: 1% buffered lidocaine|OTHER: placebo cooling spray (normal saline spray)|OTHER: Sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Dose-Rate Brachytherapy and Stereotactic Body Radiotherapy for the Treatment of Prostate Adenocarcinoma
Status: RECRUITING
Conditions: Prostate Adenocarcinoma|Stage IIB Prostate Cancer American Joint Committee on Cancer (AJCC) v8|Stage IIC Prostate Cancer AJCC v8|Stage III Prostate Cancer AJCC v8|Stage IIIA Prostate Cancer AJCC v8|Stage IIIB Prostate Cancer AJCC v8|Stage IIIC Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8
Interventions: RADIATION: High-Dose Rate Brachytherapy|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Liver or Lung Metastases From Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: BIOLOGICAL: falimarev|BIOLOGICAL: inalimarev|BIOLOGICAL: sargramostim|BIOLOGICAL: therapeutic autologous dendritic cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of an Avocado Based meDiterranean Diet on Serum Lipids for Secondary Prevention After Ischemic StrokE Trial. Study Protocol.
Status: COMPLETED
Conditions: Stroke, Acute|Stroke, Ischemic
Interventions: OTHER: Avocado-Mediterranean Diet|OTHER: Control-Group Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of Phasix™ Mesh for VHWG Grade 3 Midline Hernia Repair
Status: COMPLETED
Conditions: Hernia|Hernia, Abdominal|Hernia, Incisional
Interventions: DEVICE: Phasix™ Mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Rich Plasma Versus Radio Frequency for Chronic Knee Arthritis
Status: COMPLETED
Conditions: Osteo Arthritis Knee|Pain, Chronic
Interventions: PROCEDURE: radiofrequency|PROCEDURE: platelet rich plasma injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Cetuximab in Patients Undergoing Surgery for Peritoneal Carcinomatosis From Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer|Primary Peritoneal Cavity Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin|PROCEDURE: adjuvant therapy|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Extended Clinical Trial of Jaktinib Hydrochloride Tablets in the Treatment of Moderate and Severe Atopic Dermatitis
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: Jaktinib Hydrochloride Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dinaciclib in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Refractory Multiple Myeloma
Interventions: DRUG: dinaciclib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: fluorouracil|DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium|GENETIC: polymorphism analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Secukinumab (Cosentyx®) Effectiveness in Axial Spondyloarthritis and Psoriatic Arthritis Patients Using Artificial Intelligence (SpAINET): Spanish Multicenter, Retrospective, Real World Evidence Study
Status: COMPLETED
Conditions: Axial Spondyloarthritis|Psoriatic Arthritis
Interventions: DRUG: secukinumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Zoektocht Naar Erfelijke MetaBole Aandoening (Dutch)/ Solve The Unsolved (English)
Status: COMPLETED
Conditions: Inherited Metabolic Disorders
Interventions: DIAGNOSTIC_TEST: Untargeted metabolomics|GENETIC: WES and WGS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of 1612 Capsules in aMnestic Mild Cognitive Impairment
Status: WITHDRAWN
Conditions: Mild Cognitive Impairment
Interventions: DRUG: 1612 capsule|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Australasian Resuscitation In Sepsis Evaluation: FLUid or Vasopressors In Emergency Department Sepsis
Status: RECRUITING
Conditions: Shock, Septic
Interventions: DRUG: Vasopressor|OTHER: Fluids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ASSIST: A Surveillance Study of Illicit Substance Toxicity
Status: UNKNOWN
Conditions: Overdose, Drug|Drug Use|Drug Abuse|Drug Toxicity|Drug Effect|Illicit Drug Use|Illicit Drug Overdose|Illicit Drug Intoxication
Interventions: DIAGNOSTIC_TEST: Surplus sample toxicology analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study
Status: RECRUITING
Conditions: Cardiovascular Diseases|Natriuretic Peptides|Cardiometabolic Diseases|Energy Expenditure|Glucose Metabolism|Exercise|Obesity
Interventions: DIETARY_SUPPLEMENT: Study diet|OTHER: Exercise capacity VO2 max determination|OTHER: Exercise Challenge|OTHER: Glucose Challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Multi-centre, Open Labelled, Multiple Dosing Trial Investigating Safety, Pharmacokinetics and Pharmacodynamics of NNC 0172-2021 Administered Subcutaneously to Healthy Male Subjects and Haemophilia Subjects
Status: TERMINATED
Conditions: Congenital Bleeding Disorder|Haemophilia A|Healthy
Interventions: DRUG: NNC172-2021
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Riociguat on RIght VEntricular Size and Function in PAH and CTEPH
Status: RECRUITING
Conditions: Primary Pulmonary Arterial Hypertension|Chronic Thromboembolic Pulmonary Hypertension
Interventions: DRUG: Riociguat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iron and Immune Response to Vaccine (IRONMUM)
Status: ENROLLING_BY_INVITATION
Conditions: Pregnancy Related
Interventions: DIETARY_SUPPLEMENT: Sangobion and Thiamine Hydrochloride|DIETARY_SUPPLEMENT: Sangobion, Thiamine hydrochloride and Vitamin B12
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Echo vs. EGDT in Severe Sepsis and Septic Shock
Status: COMPLETED
Conditions: Severe Sepsis|Septic Shock
Interventions: OTHER: Echo guided fluid resuscitation|OTHER: EGDT fluid resuscitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of OBE001 Versus Placebo in the Delay of Preterm Birth
Status: TERMINATED
Conditions: Preterm Labor
Interventions: DRUG: OBE001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pericapsular Nerve Group Block Versus Fascia Iliaca Block for Pediatric Hip Surgery
Status: UNKNOWN
Conditions: Hip Surgery|Pericapsular Nerve|Fascia Iliaca
Interventions: PROCEDURE: Caudal Block group|PROCEDURE: Pericapsular nerve group block|PROCEDURE: Fascia iliaca group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Phamacokinetics of BV100 in Participants With Varying Degrees of Hepatic Impairment
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: BV100
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Variation of Orthokeratology Lens Treatment Zone (VOLTZ) Study
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Modified ortho-k lenses|DEVICE: Ortho-k lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Probiotic Supplementation on Exercise Endurance Among Non-elite Athletes
Status: COMPLETED
Conditions: Exercise Endurance
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE