pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Oral Posaconazole Three Times Per Day vs Weekly High Dose Amphotericin B Lipid Complex (ABLC)
Status: COMPLETED
Conditions: Invasive Fungal Infections|Hematologic Malignancies
Interventions: DRUG: Posaconazole|DRUG: ABLC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetically Modified Cells (KIND T Cells) for the Treatment of HLA-A*0201-Positive Patients With H3.3K27M-Mutated Glioma
Status: RECRUITING
Conditions: Diffuse Midline Glioma, H3 K27M-Mutant
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|BIOLOGICAL: Autologous Anti-H3.3K27M TCR-expressing T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effects of Dietary Fibres on the Gut Microbiome in a Transgenerational Cohort
Status: COMPLETED
Conditions: Gut Health
Interventions: DIETARY_SUPPLEMENT: Dietary Fibres Mix|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Saccharomyces Boulardii in the Treatment of Small Intestinal Bacterial Overgrowth
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Saccharomyces Boulardii 250 MG|BEHAVIORAL: Dietary advice following a low fermentation diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Wet Clothing on Thermal Protection
Status: RECRUITING
Conditions: Low Body Temperatures
Interventions: OTHER: Water-saturated Improved Hot Weather Combat Uniform|OTHER: Water-saturated Army Combat Uniform|OTHER: Water-saturated Army Combat Uniform + Silk Weights
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Naunehal - Integrated Immunization & MNCH Interventions; A Quasi-Experimental Study
Status: UNKNOWN
Conditions: Under Five Child Health Nutrition and Immunization
Interventions: OTHER: Mobile health services|OTHER: Private practitioner engagement for immunization|OTHER: Community engagement and mobilization|OTHER: Sehat Nishani - a health, nutrition and immunization app
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Internet-delivered Cognitive Behaviour Therapy for Chronic Conditions: Comparing Low Intensity Delivery Models
Status: COMPLETED
Conditions: Anxiety|Depression|Chronic Disease
Interventions: BEHAVIORAL: Team-Guided ICBT|BEHAVIORAL: Self-Guided ICBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study to Evaluate ALN-TTRSC (Revusiran) in Patients With Transthyretin (TTR) Cardiac Amyloidosis
Status: COMPLETED
Conditions: TTR-mediated Amyloidosis
Interventions: DRUG: ALN-TTRSC (revusiran) for subcutaneous administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of SYNB1891 Injection Alone or in Combination With Atezolizumab in Adult Participants
Status: TERMINATED
Conditions: Metastatic Solid Neoplasm|Lymphoma
Interventions: DRUG: SYNB1891|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Protein and Insulin Sensitivity Study
Status: COMPLETED
Conditions: Insulin Resistance|Type 2 Diabetes|Metabolic Syndrome|Cardiovascular Disease|Dyslipidemia
Interventions: OTHER: Diet|OTHER: Diet|OTHER: Diet|OTHER: Diet|OTHER: Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Bipolar Sealer for Reduction of Blood Loss in Anterior Total Hip Arthroplasties
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis, Hip|Blood Loss
Interventions: DEVICE: Werewolf Fastseal 6.0
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conventional Curettage Adenoidectomy vs Curettage Adenoidectomy With Transoral Endoscopic Residue Ablation in Children
Status: WITHDRAWN
Conditions: Adenoid Hypertrophy
Interventions: PROCEDURE: Curettage adenoidectomy with transoral endoscopic ablation|PROCEDURE: Conventional cold curettage adenoidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation (rTMS) in The Treatment of Gambling Disorder in Indonesia
Status: RECRUITING
Conditions: Gambling Disorder
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Pivmecillinam Hydrochloride Tablets in the Treatment of Uncomplicated Urinary Tract Infection
Status: COMPLETED
Conditions: Uncomplicated Urinary Tract Infection
Interventions: DRUG: Pivmecillinam hydrochloride tablets|DRUG: Fosfomycin Tromethamine Granules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-Dose Safety Study of An Influenza Vaccine (Multimeric-001) Injected to Elderly Volunteers
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Multimeric-001 250 mcg|BIOLOGICAL: Adjuvanted Multimeric-001 250mcg|BIOLOGICAL: Placebo|BIOLOGICAL: Adjuvant: Montonide isa 51 VG|BIOLOGICAL: Multimeric-001 500 mcg|BIOLOGICAL: Adjuvanted Multimeric-001 500mcg|BIOLOGICAL: TIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Phase I Clinical Trial of a Candidate Herpes Zoster Vaccine
Status: NOT_YET_RECRUITING
Conditions: Herpes Zoster
Interventions: BIOLOGICAL: Recombinant Zoster Vaccine|BIOLOGICAL: Placebo|BIOLOGICAL: Zoster Vaccine Recombinant, Adjuvanted
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bendamustine in Combination With Rituximab as a First-line Therapy Followed by Maintenance Therapy With Rituximab in Patients With Follicular Lymphoma
Status: UNKNOWN
Conditions: Follicular Lymphoma
Interventions: DRUG: Rituximab, bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Orally Administered AG-881 in Patients With Advanced Hematologic Malignancies With an IDH1 and/or IDH2 Mutation
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome|Hematologic Malignancies
Interventions: DRUG: AG881
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Intravesical Vaccine Therapy in Treating Patients With Bladder Carcinoma Who Are Undergoing Cystectomy
Status: TERMINATED
Conditions: Bladder Adenocarcinoma|Bladder Squamous Cell Carcinoma|Bladder Urothelial Carcinoma|Recurrent Bladder Carcinoma|Stage I Bladder Cancer|Stage II Bladder Cancer|Stage III Bladder Cancer|Stage IV Bladder Cancer
Interventions: BIOLOGICAL: Recombinant Fowlpox-TRICOM Vaccine|BIOLOGICAL: Recombinant Fowlpox GM-CSF Vaccine Adjuvant|PROCEDURE: Therapeutic Conventional Surgery|OTHER: Pharmacological Study|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Glucose Monitoring for High-Risk Type 2 Diabetes in the Hospital (Cyber GEMS)
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: DEVICE: Dexcom G6 Continous Glucose Monitoring Management|DEVICE: Usual Care - Blinded Continuous Glucose Monitoring Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of an Amino Acid Composition With Micronutrients on Wellbeing of Patients With Chronic Exhaustion Conditions
Status: COMPLETED
Conditions: Psychological Distress
Interventions: DIETARY_SUPPLEMENT: BOT-01|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Medical and Surgical Treatment of Uncomplicated Acute Appendicitis in Children
Status: COMPLETED
Conditions: Appendicitis
Interventions: DRUG: Piperacillin/Tazobactam|PROCEDURE: Surgical Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Neoadjuvant Laparoscopic Hyperthermic Intraperitoneal Chemotherapy (HIPEC) With Chemoradiation
Status: RECRUITING
Conditions: Gastric Cancer|Stomach Cancer
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Dexamethasone|DRUG: Diphenhydramine|DRUG: Famotidine|DRUG: Palonosetron|RADIATION: 3D conformal or intensity modulated radiotherapy|PROCEDURE: Surgical resection|RADIATION: Adjuvant Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Placebo on Intratissue Percutaneous Electrolysis in Patellar Tendinopathy
Status: RECRUITING
Conditions: Patellar Tendinopathy
Interventions: OTHER: IPE applied, participants believe they are receiving IPE|OTHER: IPE applied, participants believe they are receiving placebo|OTHER: IPE not applied, participants believe they are receiving IPE|OTHER: IPE not applied, participants believe they are receiving placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of TARCEVA (Erlotinib) as Adjuvant Treatment for Locally Advanced Head and Neck Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Erlotinib|DRUG: Erlotinib plus sulindac|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Subcutaneous Mircera in Participants With Chronic Kidney Disease Not Treated With ESA or on Dialysis
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Methoxy polyethylene glycol-epoetin beta
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment to Improve Sleep in Caregivers With Insomnia and a Child With Autism
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Insomnia Chronic|Caregiver Burden
Interventions: BEHAVIORAL: Cognitive behavioral therapy for Insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study Comparing Oral Ixazomib Plus Lenalidomide and Dexamethasone Versus Placebo Plus Lenalidomide and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Relapsed Multiple Myeloma|Refractory Multiple Myeloma
Interventions: DRUG: Ixazomib|DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Left Atrial Appendage CLOSURE for the Prevention of Thromboembolisms in Patients Undergoing Aortic Bioprosthesis Surgery
Status: RECRUITING
Conditions: Aortic Stenosis
Interventions: PROCEDURE: Surgical closure of left atrial appendage|PROCEDURE: No closure of left atrial appendage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Epratuzumab in Systemic Lupus Erythematosus
Status: WITHDRAWN
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Epratuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Clinical Activity of HH2853
Status: RECRUITING
Conditions: FL Lymphoma|Epithelioid Sarcoma|Peripheral T Cell Lymphoma|Advanced Solid Tumor
Interventions: DRUG: HH2853 Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in Retinovascular Imaging
Status: TERMINATED
Conditions: Age-related Macular Degeneration|Diabetic Retinopathy|Hypertensive Retinopathy|Retinal Vein Occlusion|Retinal Artery Occlusion
Interventions: PROCEDURE: Phase variance optical coherence tomography (PV-OCT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Change in Plaque Characteristics With Atorvastatin
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Atherosclerosis|Dyslipidemia
Interventions: DRUG: high-dose atorvastatin|DRUG: low-dose atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of the Efisiotrack System for Monitoring Patients With Shoulder Orthopedic Injuries
Status: RECRUITING
Conditions: Shoulder Injuries
Interventions: PROCEDURE: eFisioTrack Group|PROCEDURE: Excercises Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ropeginterferon Alfa-2b (P1101) Phase 3 Study in Interferon Treatment-Naive Subjects With HCV Genotype 2 Infection
Status: COMPLETED
Conditions: Chronic Hepatitis C Virus Infection
Interventions: DRUG: P1101 + Ribavirin|DRUG: PEG-Intron + Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: rTMS and EF Training for Working Memory Deficits in Adolescent Psychopathology
Status: UNKNOWN
Conditions: ADHD With Working Memory Deficits
Interventions: DEVICE: Magstim Super Rapid2 stimulator, 10 Hz condition|DEVICE: Magstim Super Rapid2 stimulator, Sham condition|DEVICE: Magstim Super Rapid2 stimulator, iTBS condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma|Hypopharyngeal Squamous Cell Carcinoma|Laryngeal Squamous Cell Carcinoma|Laryngeal Squamous Cell Carcinoma, Spindle Cell Variant|Lip and Oral Cavity Squamous Cell Carcinoma|p16INK4a Negative Oropharyngeal Squamous Cell Carcinoma|Stage III Hypopharyngeal Carcinoma AJCC v8|Stage III Laryngeal Cancer AJCC v8|Stage III Lip and Oral Cavity Cancer AJCC v8|Stage III Oral Cavity Verrucous Carcinoma|Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IVA Hypopharyngeal Carcinoma AJCC v8|Stage IVA Laryngeal Cancer AJCC v8|Stage IVA Lip and Oral Cavity Cancer AJCC v8|Stage IVA Oral Cavity Verrucous Carcinoma|Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Interventions: DRUG: Cisplatin|RADIATION: Intensity-Modulated Radiation Therapy|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacodynamics, and Pharmacokinetics of BIBT 1011 BS in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Single rising doses of BIBT 1011 BS|DRUG: BIBT 1011 BS placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Anesthesia on Patients Undergoing Surgery for Repair of a Thoracoabdominal Aneurysm.
Status: TERMINATED
Conditions: Thoracic Aneurysm|Aneurysm Stent|Cardiopulmonary Bypass|Abdominal Aneurysm
Interventions: DRUG: Propofol|DRUG: isoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Dosing Study of Ara-C/EL625/Idarubicin in Refractory and Relapsed AML
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia
Interventions: DRUG: cenersen|DRUG: Idarubicin|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Lateral Nerve of the Thigh Block on Postoperative Pain After Total Hip Replacement Surgery
Status: COMPLETED
Conditions: Pain, Postoperative|Anesthesia, Conduction|Arthroplasty, Replacement, Hip
Interventions: DRUG: Ropivacaine|DRUG: Placebo|DEVICE: An ultrasound-guided Nervus cutaneous femoral lateralis blockade will be given postoperatively
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Improving the Efficacy of Treatment in High Risk T Cell Lymphoma Patients
Status: UNKNOWN
Conditions: T-cell Lymphoma Adults|Previously Untreated|High Risk
Interventions: DRUG: chemotherapy (CHOP)|DRUG: chemotherapy(c-ATT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increase Protein Intake of Older Meal Service Clients With Readymade Protein-rich Meals and Foods
Status: COMPLETED
Conditions: Malnutrition; Protein|Protein Malnutrition
Interventions: OTHER: Nutritional intervention - protein-rich|OTHER: Nutritional intervention - standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Project 4, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Pregnant Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Tobacco Use Disorder
Interventions: OTHER: Very low nicotine content cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immediate Prostatectomy vs. Cabozantinib Followed by Prostatectomy in Men With High-Risk Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer|Prostate Cancer Adenocarcinoma|Non-Metastatic
Interventions: DRUG: Cabozantinib|PROCEDURE: Radical Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Intranasal Anti-IgE Antibodies on IgE Production
Status: COMPLETED
Conditions: Allergy
Interventions: DRUG: anti-IgE|OTHER: intranasal allergen|OTHER: intranasal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study on the Safety and Efficacy of MR-Linac Technique in Patients With Unresectable Locally Advanced Colon Cancer
Status: NOT_YET_RECRUITING
Conditions: Safety and Efficacy
Interventions: RADIATION: MR-linac
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic, Efficacy, Safety, and Immunogenicity of AVT02 With Moderate to Severe Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: BIOLOGICAL: Adalimumab originator|BIOLOGICAL: Adalimumab biosimilar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Arsenic Trioxide, Fluorouracil, and Leucovorin in Treating Patients With Stage IV Colorectal Cancer That Has Relapsed or Not Responded to Treatment
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Arsenic trioxide|DRUG: Fluorouracil|DRUG: Leucovorin calcium|OTHER: Plasma levels of elemental arsenic|GENETIC: Peripheral Blood Mononuclear Cells (PBMC) for mRNA analysis|PROCEDURE: Tumor Biopsy (Fine-Needle Aspiration)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total Knee Arthroplasty (TKA) Cemented Versus Cementless Tibial Prosthesis Study
Status: COMPLETED
Conditions: Osteoarthritis|Post-traumatic Osteoarthritis|Rheumatoid Arthritis
Interventions: PROCEDURE: Cemented Tibia|PROCEDURE: Cementless Tibia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Supporting Parents to Choose Wisely
Status: ACTIVE_NOT_RECRUITING
Conditions: Common Cold|Pharyngitis|Acute Otitis Media|Acute Asthma|Bronchiolitis|Pediatric ALL|Parents
Interventions: BEHAVIORAL: Blogshots 1-3|BEHAVIORAL: Blogshots 4-6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cardiovascular Effects of Chronic Sildenafil in Men With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Endothelial Dysfunction
Interventions: DRUG: Sildenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Of Sunitinib In Patients With Recurrent Paraganglioma/Pheochromocytoma
Status: COMPLETED
Conditions: Paraganglioma|Pheochromocytoma
Interventions: DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wiser Choices in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: OTHER: AMI Choice Decision Aid|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nutrient Supplementation Influences Mitochondria Adaptation
Status: COMPLETED
Conditions: Performance|Nutrition|Protein
Interventions: DIETARY_SUPPLEMENT: PROTEIN-CARBOHYDRATE|DIETARY_SUPPLEMENT: CARBOHDYRATE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effect on Clip Markers After Vacuum-Assisted Biopsy by Postprocedure Mammogram
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: Breast Biopsy|PROCEDURE: Post Procedure Mammogram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Exercise Training Improves Coronary Endothelial Dysfunction in Diabetes Mellitus Type 2 and Coronary Artery Disease
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Coronary Artery Disease
Interventions: BEHAVIORAL: Exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Home-based Assessment of PRO Measures in SCD Using A Smartphone App Platform: A Feasibility Study
Status: COMPLETED
Conditions: Sickle Cell Disease|Sickle Cell Hemoglobin C|Sickle Beta Zero Thalassemia|Sickle B+ Thalassemia
Interventions: BEHAVIORAL: PROs assessment using sickle cell disease mobile app (SCD-app)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acceptability of a Multiple Micronutrient-Fortified Lipid-Based Nutrient Supplement for Children Under Two in Cambodia
Status: COMPLETED
Conditions: Child Malnutrition
Interventions: DIETARY_SUPPLEMENT: LNS snack|DIETARY_SUPPLEMENT: Corn-soy blend ++ (CSB++)|DIETARY_SUPPLEMENT: Sprinkles|DIETARY_SUPPLEMENT: LNS + borbor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment of Medication Optimization in Rural Kentucky Appalachian Patients With Mild Cognitive Impairment or Dementia
Status: TERMINATED
Conditions: Dementia|Mild Cognitive Impairment
Interventions: BEHAVIORAL: Medication therapy management
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase I-IIa, to Evaluate the Safety, Feasibility, and Efficacy of the Use of BIOCLEFT in the Treatment of Cleft Palate.
Status: RECRUITING
Conditions: Cleft Lip and Palate
Interventions: PROCEDURE: implantation with an autologous human palatal mucosa substitute made of nanostructured fibrin-agarose generated by tissue engineering (BIOCLEFT).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Fentanyl Transdermal Therapeutic System (TTS) in the Management of Pain in Patients With Cancer
Status: COMPLETED
Conditions: Pain|Cancer
Interventions: DRUG: Fentanyl Transdermal Therapeutic System (TTS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Morphological, Spectral and Metabolic Manifestations of Neurological Complications in Covid-19 Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Covid19|Neurological Manifestations|Brain Damage
Interventions: OTHER: Magnetic Resonance Spectroscopy (MRS).
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Tralokinumab in Combination With Topical Corticosteroids in Subjects With Severe Atopic Dermatitis - ECZTRA 7
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Tralokinumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Study of Omalizumab (CMAB007 and Xolair) in Healthy Subjects to Compare the PK, PD and Safety
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Omalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Quantifying Systemic Immunosuppression to Personalize Cancer Therapy
Status: UNKNOWN
Conditions: Melanoma|Breast Cancer|Renal Cell Carcinoma|Urinary Bladder Cancer|Squamous Cell Carcinoma of Head and Neck|Small Cell Carcinoma|NSCLC
Interventions: OTHER: MDSC quantification
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Smokers With and Without Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Nicotine Dependence
Interventions: BEHAVIORAL: Smoking Cues|BEHAVIORAL: Neutral Cues
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Local Remodelling of Bone Fracture Healing
Status: COMPLETED
Conditions: Fracture Healing|Distal Radius Fracture
Interventions: DIAGNOSTIC_TEST: HR-pQCT (high resolution computertomograph)|DIAGNOSTIC_TEST: Blood withdrawal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Naftopidil 75mg for Improving Clearance of Urinary Stones
Status: UNKNOWN
Conditions: Kidney Calculi|Ureter Calculi
Interventions: DRUG: naftopidil 75mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: eRAPID: Online Symptom Reporting in Lung Cancer
Status: COMPLETED
Conditions: Thoracic Cancer|Non-small Cell Lung Cancer|Small-cell Lung Cancer|Pleural Mesothelioma
Interventions: OTHER: eRAPID online symptom monitoring in lung cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Compounded Topical Anesthetics
Status: NOT_YET_RECRUITING
Conditions: Procedural Pain
Interventions: DRUG: Lidocaine topical|DRUG: BLT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Strategies to Improve Schizophrenia Treatment
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: BEHAVIORAL: Team-Based Quality Improvement Intervention|BEHAVIORAL: Opinion Leader Intervention|BEHAVIORAL: Team Based Quality Improvement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Study to Test the Validity of the Treatment of Idiopathic Pulmonary Fibrosis With Cotrimoxazole
Status: TERMINATED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Cotrimoxazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Assessing the Safety, Tolerability, and Pharmacokinetics of SEP-363856 in Japanese Male and Female Subjects With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: SEP-363856|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Assess Response to Oral Vitamin D3 Supplementation in Obese Individuals
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Oral vitamin D3|DIETARY_SUPPLEMENT: Placebo equivalent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Multifocal Contact Lens Use in Previous Contact Lens Wearers With Near Vision Demands
Status: COMPLETED
Conditions: Presbyopia
Interventions: DEVICE: lotrafilcon B multifocal contact lens|DEVICE: lotrafilcon B single vision contact lens|OTHER: Over-reader spectacles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2022 and 2025
Status: RECRUITING
Conditions: Radiation Toxicity|Chemotherapeutic Toxicity|Chemotherapy-induced Peripheral Neuropathy|Delayed Wound Healing|Chronic Pain|Refractory Pain
Interventions: OTHER: Ozone therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Acupuncture in Patients With Acute Intracranial Hemorrhage
Status: RECRUITING
Conditions: Intracranial Hemorrhages
Interventions: PROCEDURE: Acupuncture|PROCEDURE: Sham Acupuncture(Superficial Acupuncture)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation for Chronic Neuropathic Pain
Status: RECRUITING
Conditions: Chronic Neuropathic Pain|Post-Stroke Pain|Trigeminal Neuralgia|Nerve Injury|Spinal Cord Injuries|Pain, Postoperative|Complex Regional Pain Syndromes|Post-herpetic Neuralgia|Nerve Root Avulsion
Interventions: DEVICE: High Frequency rTMS|DEVICE: Low Frequency rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Alpha-tocopherol in Hemolysis and Oxidative Stress Marker on the Red Cell Membrane Beta-thalassemia Major
Status: COMPLETED
Conditions: Beta Thalassemia Major Anemia|Hemolysis|Oxidative Stress
Interventions: DRUG: Alpha-Tocopherol|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Clinical Study of Leflunomide in the Treatment of MEN-1 Neuroendocrine Tumor
Status: RECRUITING
Conditions: Neuroendocrine Tumors
Interventions: DRUG: Leflunomide Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Target Versus Standard Human Milk Fortification in Very Low Birth Weight Preterm Infants
Status: COMPLETED
Conditions: Postnatal Growth Failure of Preterm Infants|Human Milk Fortification
Interventions: DIETARY_SUPPLEMENT: Addition of human milk fortifiers according to human milk analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Simplified Drug Regimens for HIV Patients in ACTG 388 or Patients Who Responded to A First Potent Combination Regimen
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: lopinavir/ritonavir|DRUG: lamivudine/zidovudine|DRUG: efavirenz|DRUG: lamivudine|DRUG: stavudine|DRUG: zidovudine|DRUG: didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Stannsoporfin in Neonates
Status: COMPLETED
Conditions: Nutritional and Metabolic Diseases
Interventions: DRUG: stannsoporfin|OTHER: Sham Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Expanded Access Program to Axitinib is Available for Patients With Advanced Forms of Kidney Cancer (Ductal; Papillary; Chromophobic; Oncocytic) With Mutations in VHL, PBRM1 / BAP1, SETD2, VEGF)
Status: AVAILABLE
Conditions: Clear Cell Kidney Cancer|Kidney Cancer|Kidney Cancer With PBRM1/BAP1/VHL/SETD2 Mutations
Interventions: DRUG: Axitinib 5 MG
Study Type: EXPANDED_ACCESS
Clinical trial: Study to Assess Safety, Tolerability, Pharmacokinetics and Antitumor Activity of AZD4573 in Relapsed/Refractory Haematological Malignancies
Status: COMPLETED
Conditions: Relapsed or Refractory Haematological Malignancies Including|Acute Myeloid Leukemia|Acute Lymphocytic Leukemia|Chronic Lymphocytic Leukemia|High Risk Myelodysplastic Syndrome|Chronic Myelomonocytic Leukemia|Richter's Syndrome|B-cell Non-Hodgkin Lymphoma|T-cell Non-Hodgkin Lymphoma|Small Lymphocytic Lymphoma|Multiple Myeloma
Interventions: DRUG: AZD4573
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CRISPR/Cas9 Instantaneous Gene Editing Therapy to Intraocular Hypertensive POAG With MYOC Mutation
Status: RECRUITING
Conditions: Primary Open Angle Glaucoma
Interventions: GENETIC: BD113vVLP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plant Protein Blend and Milk Protein Supplements in Older Individuals
Status: RECRUITING
Conditions: Sarcopenia|Skeletal Muscle Atrophy|Protein Malnutrition
Interventions: BEHAVIORAL: Resistance exercise|BEHAVIORAL: Standardized diet|DIETARY_SUPPLEMENT: Plant protein supplement|DIETARY_SUPPLEMENT: Maltodextrin supplement|DIETARY_SUPPLEMENT: Milk protein supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of A New Technique of Measure of the Insulin Resistance By Scintigraphy With the Reference Technique
Status: COMPLETED
Conditions: Diabetes Mellitus|Insulin Resistance|Glucose Metabolism Disorders|Metabolic Diseases|Endocrine System Diseases
Interventions: DRUG: 6-DIG|PROCEDURE: clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Peer-Supported Diabetes Self-Care Intervention to Improve Health Related Quality of Life (HRQoL) and Diabetes Management
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Peer supported diabetes self-care intervention|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Transcranial Direct Current Stimulation to Reduce Chronic Pain in Patients With Chronic Inflammatory Bowel Diseases
Status: COMPLETED
Conditions: Inflammatory Bowel Disease
Interventions: DEVICE: Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eggshell Membrane Beauty From Within Trial
Status: COMPLETED
Conditions: Skin Elasticity|Skin Hydration|Skin Barrier to Water Loss|Fingernail Health|Hair Health
Interventions: DIETARY_SUPPLEMENT: unhydrolyzed eggshell membrane|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Development of a Normative Database for Rheumatoid Arthritis (RA) Imaging With Tc99m Tilmanocept
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tc99m tilmanocept
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Online Social Support Program for Physical and Mental Health of Filipino Migrant Domestic Workers in Hong Kong
Status: RECRUITING
Conditions: Healthy Diet|Mental Health Wellness
Interventions: BEHAVIORAL: T1: Mixed mode social support group|BEHAVIORAL: T2: Online mode social support group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Women's Lifestyle Balance Study
Status: COMPLETED
Conditions: PreDiabetes|Metabolic Syndrome|Overweight
Interventions: BEHAVIORAL: CDC's PreventT2 Program|BEHAVIORAL: CDC's PreventT2 Program with Added Sleep Content
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Docetaxel Before Degarelix in Patients With Newly Diagnosed Metastatic Prostate Cancer.
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Prostatic Adenocarcinoma
Interventions: DRUG: Docetaxel|DRUG: Degarelix
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Controlled Trial to Assess the Immunogenicity of a Proposed Paediatric Dosing Schedule of Human Papillomavirus Vaccine
Status: COMPLETED
Conditions: Cervical Cancer|Genital Warts
Interventions: BIOLOGICAL: HPV (Human Papillomavirus) Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Safety and Effectiveness of Two Experimental Malaria Vaccines
Status: RECRUITING
Conditions: Malaria|Malaria,Falciparum|Parasitic Disease|Vector Borne Diseases|Infections
Interventions: BIOLOGICAL: RH5.1 and/or RH5.2-VLP with Matrix-M
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Esketamine on Postoperative Behavioral Changes in Children Undergoing Tonsillectomy and Adenoidectomy
Status: NOT_YET_RECRUITING
Conditions: Behavior Problem
Interventions: DRUG: Esketamine hydrochloride|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: EEG-guided Propofol Sedation Versus Standard Care for Oesophagogastroduodenoscopy and Colonoscopy in Children
Status: RECRUITING
Conditions: Anesthesia|Anesthesia; Adverse Effect|Anesthesia Emergence Delirium|Sedation Complication|Sedative Adverse Reaction
Interventions: DEVICE: Sedline EEG monitoring|DEVICE: Sedline EEG with output concealed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Supplementation With B. Infantis for Mitigation of Type 1 Diabetes Autoimmunity
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1
Interventions: DIETARY_SUPPLEMENT: B. infantis|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics of Single and Multiple Escalating Doses of Aramchol and Food Effect in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Aramchol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-859/KEYNOTE-859)
Status: ACTIVE_NOT_RECRUITING
Conditions: Stomach Neoplasms
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Cisplatin|DRUG: 5-fluorouracil|DRUG: oxaliplatin|DRUG: capecitabine|DRUG: Placebo for Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Medication Adherence of Patients Treated With Telmisartan/Hydrochlorothiazide or Telmisartan/Amlodipine Fixed Dose Combination (FDC) Versus Double-pill Combination Therapy in Real-world Japanese Therapeutic Practice
Status: WITHDRAWN
Conditions: Hypertension
Interventions: DRUG: subjects treated with telmisartan/hydrochlorothiazide|DRUG: Subjects treated with Telmisartan and amlodipine|DRUG: subjects treated with Telmisartan+hydrochlorothiazide double-pill combination group|DRUG: subjects treated with telmisartan+amlodipine double pill
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Endostar Combined With Corticosteroid for Treatment of Radiation-induced Brain Necrosis in Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Endostar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paracoracoid Subscapularis Plane Block Versus Iso Block for Shoulder Surgery for Shoulder Surgery
Status: UNKNOWN
Conditions: Post Operative Pain
Interventions: PROCEDURE: Infraclavicular and subomohoid block|PROCEDURE: Paracoracoid subscapularis plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Efficacy, and Tolerability of SNA-120 in Subjects With Pruritus Associated With Psoriasis Vulgaris
Status: COMPLETED
Conditions: Pruritus|Psoriasis Vulgaris
Interventions: DRUG: SNA-120|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Levosimendan In Ambulatory Heart Failure Patients
Status: NOT_YET_RECRUITING
Conditions: Heart Failure New York Heart Association Class III|Heart Failure New York Heart Association Class IV|Heart Failure, Systolic|Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: Levosimendan|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Metabolic Markers for the Prediction of DDI of Various CYP3A Substrates and Inhibitors
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Sildenafil|DRUG: Clarithromycin|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma
Status: COMPLETED
Conditions: Cardiac Toxicity|Sarcoma
Interventions: DRUG: cisplatin|DRUG: dexrazoxane hydrochloride|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: methotrexate|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-operative One-on-One Physical Therapy Education Improves Postoperative Function and Patient Satisfaction After Total Joint Arthroplasty
Status: COMPLETED
Conditions: Arthroplasty
Interventions: BEHAVIORAL: Preoperative Physical Therapy Session|BEHAVIORAL: Group Preoperative Education Session (per the standard of care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Ascorbic Acid on Post-Cardiothoracic Surgery Inflammation
Status: COMPLETED
Conditions: Cardiac Surgery|Inflammation
Interventions: DRUG: Ascorbic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION