pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Reproducibility and Utility of OGTT in Acromegaly
Status: UNKNOWN
Conditions: Acromegaly
Interventions: OTHER: Performed 3 diagnostic tests (2 OGTT tests with 75 g of Glucose and 1 placebo test with 375 mg of Aspartam|OTHER: Performed 2 diagnostic tests (2 OGTT tests with 75g of Glucose)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Octreotide in the Prevention of Diarrhea in Patients Receiving Irinotecan for Metastatic Colon Cancer
Status: TERMINATED
Conditions: Colorectal Cancer|Diarrhea
Interventions: DRUG: irinotecan hydrochloride|DRUG: octreotide acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: STUDY 15 - Comparing Gemcitabine/Carboplatin and Hydroxychloroquine Versus Carboplatin/Etoposide Therapy Alone in Small Cell Lung Cancer (SCLC)
Status: TERMINATED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Gemcitabine|DRUG: Carboplatin|DRUG: Etoposide|DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics Study of Cefazolin in Hemodialysis (CEFAZODIAL)
Status: RECRUITING
Conditions: Hemodialysis Catheter Infection|Infection, Bacterial
Interventions: BIOLOGICAL: Blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azithromycin Dose and PPROM Treatment: a Pilot Randomized Controlled Trial
Status: COMPLETED
Conditions: Preterm Premature Rupture of Membrane
Interventions: DRUG: Azithromycin 500 mg|DRUG: Azithromycin Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peripheral Blood Stem Cell Transplantation (PBSCT)From Haploidentical Related Donors
Status: COMPLETED
Conditions: Hematologic Neoplasms|Anemia, Aplastic|Hemoglobinuria, Paroxysmal|Multiple Myeloma
Interventions: OTHER: haploidentical allogeneic PBSC transp
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Water as Therapy in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Status: COMPLETED
Conditions: Autosomal Dominant Polycystic Kidney Disease
Interventions: OTHER: Water prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab in the Treatment of HIV Associated Multicentric Castleman Disease Dependent on Chemotherapy
Status: TERMINATED
Conditions: HIV Infections|Giant Lymph Node Hyperplasia
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Association Between Health Care Provider (HCP)-Assessed ECOG Performance Status (PS) and Overall Survival, and Objectively Measure of Physical Activity (PA) Levels in Advance-cancer Patients"
Status: RECRUITING
Conditions: Malignant Head and Neck Neoplasm|Malignant Neoplasm|Metastatic Malignant Neoplasm in the Neck|Metastatic Malignant Neoplasm in the Uterine Cervix|Pancreatic Adenocarcinoma|Pancreatic Neuroendocrine Carcinoma|Recurrent Colorectal Carcinoma|Stage I Colorectal Cancer AJCC v6 and v7|Stage I Hypopharyngeal Carcinoma AJCC v7|Stage I Major Salivary Gland Cancer AJCC v7|Stage I Nasopharyngeal Carcinoma AJCC v7|Stage I Oral Cavity Cancer AJCC v6 and v7|Stage I Oropharyngeal Carcinoma AJCC v6 and v7|Stage II Colorectal Cancer AJCC v7|Stage II Hypopharyngeal Carcinoma AJCC v6 and v7|Stage II Major Salivary Gland Cancer AJCC v7|Stage II Nasopharyngeal Carcinoma AJCC v7|Stage II Oral Cavity Cancer AJCC v6 and v7|Stage II Oropharyngeal Carcinoma AJCC v6 and v7|Stage IIA Colorectal Cancer AJCC v7|Stage IIB Colorectal Cancer AJCC v7|Stage IIC Colorectal Cancer AJCC v7|Stage III Colorectal Cancer AJCC v7|Stage III Hypopharyngeal Carcinoma AJCC v7|Stage III Laryngeal Cancer AJCC v6 and v7|Stage III Major Salivary Gland Cancer AJCC v7|Stage III Nasopharyngeal Carcinoma AJCC v7|Stage III Oral Cavity Cancer AJCC v6 and v7|Stage III Oropharyngeal Carcinoma AJCC v7|Stage IIIA Colorectal Cancer AJCC v7|Stage IIIB Colorectal Cancer AJCC v7|Stage IIIC Colorectal Cancer AJCC v7|Stage IV Colorectal Cancer AJCC v7|Stage IVA Colorectal Cancer AJCC v7|Stage IVA Hypopharyngeal Carcinoma AJCC v7|Stage IVA Laryngeal Cancer AJCC v7|Stage IVA Major Salivary Gland Cancer AJCC v7|Stage IVA Nasopharyngeal Carcinoma AJCC v7|Stage IVA Oral Cavity Cancer AJCC v6 and v7|Stage IVA Oropharyngeal Carcinoma AJCC v7|Stage IVB Colorectal Cancer AJCC v7|Stage IVB Hypopharyngeal Carcinoma AJCC v7|Stage IVB Laryngeal Cancer AJCC v7|Stage IVB Major Salivary Gland Cancer AJCC v7|Stage IVB Nasopharyngeal Carcinoma AJCC v7|Stage IVB Oral Cavity Cancer AJCC v6 and v7|Stage IVB Oropharyngeal Carcinoma AJCC v7|Metastatic or Locally Unresectable Solid Tumor
Interventions: BEHAVIORAL: Exercise Intervention|OTHER: Health Telemonitoring|OTHER: Health Telemonitoring|OTHER: Health Telemonitoring|OTHER: Health Telemonitoring|OTHER: Health Telemonitoring|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|OTHER: Health Telemonitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Corneal Epithelial Autograft With Middle Lamellar Keratoplasty for Severe Ocular Burns
Status: COMPLETED
Conditions: Ocular Burns
Interventions: PROCEDURE: EA and AMLK|PROCEDURE: LA and AMLK
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism
Status: RECRUITING
Conditions: Opioid Use|Pain|Hypogonadism, Male
Interventions: DRUG: Testosterone Undecanoate 250 MG/ML|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Direct HIS-pacing as an Alternative to BiV-pacing in Symptomatic HFrEF Patients With True LBBB
Status: COMPLETED
Conditions: Heart Failure With Reduced Ejection Fraction|Left Bundle-Branch Block
Interventions: PROCEDURE: Implantation of a HIS-pacing lead|PROCEDURE: Implantation of a LV-pacing lead
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A/H1N1 Immunogenicity and Safety in Infants, Children and Adolescents
Status: COMPLETED
Conditions: Influenza|Pandemic Influenza
Interventions: BIOLOGICAL: H1N1 pandemic influenza vaccine (whole virion, Vero cell-derived, inactivated)|BIOLOGICAL: Seasonal trivalent influenza vaccine (licensed) for the season 2010/2011
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Family-centered Obesity Prevention: Communities for Healthy Living (CHL)
Status: SUSPENDED
Conditions: Pediatric Obesity|Obesity
Interventions: BEHAVIORAL: Parents Connect for Healthy Living (PConnect)|BEHAVIORAL: Enhanced Nutrition Support|BEHAVIORAL: Media Resources
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Drug-Drug Interaction of Darunavir/Ritonavir on Pitavastatin
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pitavastatin (NK-104)|DRUG: Darunavir/Ritonavir (Prezista)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Clinical Trial to Evaluate Clifutinib in Patients With Relapsed or Refractory Acute Myeloid Leukemia(AML)
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Clifutinib Besylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Radiation Therapy Followed By Surgery in Treating Patients With Stage IIB or Stage IIIA Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: paclitaxel|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: Micronized Dehydrated Human Amniotic Membrane Suspension in the Treatment of Lateral Epicondylitis
Status: TERMINATED
Conditions: Epicondylitis, Lateral Humeral
Interventions: BEHAVIORAL: Standard of Care Therapy|OTHER: dHACM Injection|OTHER: Normal Saline Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise and Testosterone Therapy in Elderly Men With Physical Frailty
Status: COMPLETED
Conditions: Physical Frailty|Hip Fracture|Elective Hip Replacement|Hypogonadism
Interventions: DRUG: Transdermal Testosterone gel (1%)|BEHAVIORAL: Supervised exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cisplatin + Radiation in SCCHN and Correlation With Oxidative Stress Markers
Status: RECRUITING
Conditions: Carcinoma, Squamous Cell|Head and Neck Cancer
Interventions: DRUG: Cisplatin|RADIATION: XRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Stereo-tActic BoDy RadIotherApy iN Oligo-Progressive MalignanT Disease
Status: RECRUITING
Conditions: Malignancy|Breast Cancer Metastatic|Genito-urinary
Interventions: RADIATION: Stereotactic Body Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Near-Infrared Light Photobiomodulation Treatment for Retinal Vein Occlusion Macular Oedema
Status: UNKNOWN
Conditions: Macula Edema|Retinal Vein Occlusion
Interventions: DEVICE: Ellex Integre NIR laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Isoniazid, Rifampicin and Moxifloxacin for the Intensive Phase of Initial Therapy of PTB
Status: UNKNOWN
Conditions: Pulmonary Tuberculosis
Interventions: DRUG: Moxifloxacin, Isoniazid, Rifampicin|DRUG: Rifampicin,Isoniazid,Pyrazinamide,Ethambutol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effectiveness and Safety of an Implant in the Treatment of Osteoarthritis of the Great Toe
Status: COMPLETED
Conditions: Osteoarthritis of First Metatarsalphalangeal Joint
Interventions: DEVICE: Arthrodesis|DEVICE: Cartiva
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Vimseltinib (DCC-3014) in Patients With Advanced Tumors and Tenosynovial Giant Cell Tumor
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Neoplasm|Pigmented Villonodular Synovitis|Giant Cell Tumor of Tendon Sheath|Tenosynovial Giant Cell Tumor|Tenosynovial Giant Cell Tumor, Diffuse
Interventions: DRUG: Vimseltinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Antibiotic Outpatient Therapy vs. Placebo in the Treatment of Uncomplicated Acute Appendicitis
Status: NOT_YET_RECRUITING
Conditions: Uncomplicated Acute Appendicitis
Interventions: DRUG: Moxifloxacin 400mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Neutralizing Antibodies and Vaccination for Induction of HIV Remission
Status: WITHDRAWN
Conditions: HIV-1-infection
Interventions: BIOLOGICAL: VRC07-523LS|BIOLOGICAL: PGDM1400LS|BIOLOGICAL: N-803|BIOLOGICAL: Ad26.Mos4.HIV|BIOLOGICAL: MVA-BN-HIV|BIOLOGICAL: A244d11 gp120|BIOLOGICAL: ALFQ|COMBINATION_PRODUCT: Antiretroviral Therapy (ART)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Diluted Sodium Hypochlorite Solution and Moisturizers on Skin Barrier Function in Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: OTHER: Bleach Bath and Moisturizers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: BCMA-CS1 Compound CAR (cCAR) T Cells for Relapsed/Refractory Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: BCMA-CS1 cCAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Oral Bexarotene in Combination With Photopheresis for Treatment of Cutaneous T-Cell Lymphoma
Status: COMPLETED
Conditions: Cutaneous T-Cell Lymphoma
Interventions: DRUG: bexarotene|DEVICE: photopheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quality Measurement and Improvement Study of Surgical Coronary Revascularization: Medication Adherence
Status: UNKNOWN
Conditions: Coronary Artery Bypass Grafting|Medication Adherence|Mobile Applications
Interventions: BEHAVIORAL: APP intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: LMA Cuff Pressure and LMA-induced Complications
Status: COMPLETED
Conditions: Sore Throat|Dysphagia|Dysphonia
Interventions: DEVICE: Standard inflation of LMA cuff|DEVICE: Pressure check with syringe recoil|DEVICE: Pressure check by pressure transducer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Adult Rhabdomyosarcoma|Childhood Desmoplastic Small Round Cell Tumor|Chordoma|Desmoid-Type Fibromatosis|Metastatic Childhood Soft Tissue Sarcoma|Non-Metastatic Childhood Soft Tissue Sarcoma|Previously Treated Childhood Rhabdomyosarcoma|Recurrent Adult Soft Tissue Sarcoma|Recurrent Childhood Rhabdomyosarcoma|Recurrent Childhood Soft Tissue Sarcoma|Rhabdomyosarcoma|Stage I Adult Soft Tissue Sarcoma AJCC v7|Stage II Adult Soft Tissue Sarcoma AJCC v7|Stage III Adult Soft Tissue Sarcoma AJCC v7|Stage IV Adult Soft Tissue Sarcoma AJCC v7|Untreated Childhood Rhabdomyosarcoma
Interventions: OTHER: Cytology Specimen Collection Procedure|OTHER: Laboratory Biomarker Analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Asses Efficacy of Intralymphatic Immunotherapy
Status: COMPLETED
Conditions: Allergy
Interventions: BIOLOGICAL: phleum pratense (grass-allergen)|BIOLOGICAL: phleum pratense (grass allergen)|OTHER: physiological saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Shock Wave and a Tailored Exercise Program on Axillary Web Syndrome
Status: RECRUITING
Conditions: Axillary Web Syndrome
Interventions: OTHER: low-energy extracorporeal shockwave and a tailored exercise program|OTHER: low-energy extracorporeal shockwave|OTHER: tailored exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Rehabilitation Using Action Observation and Muscle Stimulation in Post-stroke Patients.
Status: RECRUITING
Conditions: Stroke|Stroke Sequelae
Interventions: OTHER: Rehabilitation protocol: AOT+NMES|OTHER: Rehabilitation protocol: Action Observation Therapy (AOT)|OTHER: Observation of motor-neutral stimuli (MNO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Apixaban for Primary Prevention of Venous Thromboembolism in Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Venous Thromboembolism|Multiple Myeloma
Interventions: DRUG: Apixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Effects of Estetrol on Testosterone Suppression and Quality of Life in Prostate Cancer Patients Treated With an LHRH Agonist.
Status: COMPLETED
Conditions: Prostatic Neoplasm
Interventions: DRUG: Estetrol|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Serotonergic Modulation of Motor Function in Subacute and Chronic SCI
Status: UNKNOWN
Conditions: Spinal Cord Injury
Interventions: DRUG: Lexapro|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Less Intensive Radiation With Chemotherapy to Treat Low-risk Patients With HPV-positive Oropharyngeal Cancer
Status: RECRUITING
Conditions: Cancer of the Head and Neck|Oropharynx Cancer|HPV Positive Oropharyngeal Squamous Cell Carcinoma|Throat Carcinoma
Interventions: DRUG: Cisplatin injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Phase III Study of Vitamins B6 and B12 to Prevent Chemotherapy-Induced Neuropathy in Cancer Patients
Status: COMPLETED
Conditions: Cancer
Interventions: DIETARY_SUPPLEMENT: Multivitamin (MV)|DIETARY_SUPPLEMENT: Multivitamin + Vitamin B12 + Vitamin B6|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Continuous Treatment With PREVENA Therapy for 14 Days
Status: RECRUITING
Conditions: Abdominal Surgery|Orthopedic Surgery|Cardiovascular Surgery|Vascular Surgery
Interventions: DEVICE: Prevena Plus Incision Management System with Prevena Dressings
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Real-World Comparison of Safety and Effectiveness of Novel Oral Anti-Coagulant (NOAC) Naïve and Warfarin Naïve Non-Valvular Atrial Fibrillation (NVAF) Patients With Medicare Advantage Coverage
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Apixaban|DRUG: Dabigatran|DRUG: Rivaroxaban|DRUG: Warfarin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Tolerability of FMT Capsules in Healthy Volunteers
Status: UNKNOWN
Conditions: Acute-graft-versus-host Disease
Interventions: BIOLOGICAL: XBI-302|BIOLOGICAL: XBI-302 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Asses the Effect of MK0663 in the Treatment of Patients With Postoperative Dental Pain (0663-092)
Status: COMPLETED
Conditions: Postoperative Dental Pain
Interventions: DRUG: Comparator: etoricoxib|DRUG: Comparator: ibuprofen|DRUG: Comparator: acetaminophen + codeine|DRUG: Comparator: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study of Apixaban in Patients With Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Apixaban|DRUG: Acetylsalicylic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Management of Prelabor Rupture of the Membranes at Term
Status: RECRUITING
Conditions: Fetal Infection|Chorioamnionitis|Endometritis|Cesarean Section Complications
Interventions: DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transversus Abdominus Plane Block
Status: COMPLETED
Conditions: Nephrectomy
Interventions: PROCEDURE: TAP block placement with placebo|PROCEDURE: Placement of block with ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Difference of Basal Insulin Titration Method in Reducing HbA1c Among Type 2 Diabetes Mellitus (T2DM) Patients.
Status: UNKNOWN
Conditions: to Identify Which Titration Regimen of Basal Insulin (Being Daily Titration vs 3 Daily Titration) is Better in Reducing hba1c and Have Lesser Hypoglycemia
Interventions: DRUG: NPH basal insulin titration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Dupilumab (REGN668/SAR231893) Monotherapy Administered to Adult Patients With Moderate-to-Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: Dupilumab|DRUG: Placebo (for Dupilumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Glucose Monitoring Evaluation of Exenatide Twice Daily Versus Insulin Glargine
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Exenatide|DRUG: Insulin Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of the Preoperative Lymph Node Staging in Patients With Cancer of the Esophagogastric Junction and Stomach
Status: WITHDRAWN
Conditions: Adenocarcinoma|Stomach Cancer|Cancer of Esophagogastric Junction
Interventions: PROCEDURE: FDG-PET-CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: PK and PD Study of Oral F/TAF for HIV Prevention
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Emtricitabine|DRUG: Tenofovir alafenamide|DRUG: Tenofovir disoproxil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lurasidone Pediatric Bipolar Study
Status: COMPLETED
Conditions: Bipolar I Depression
Interventions: DRUG: Lurasidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Morphine-Sparing Effect And Safety Of Parecoxib Administered Intravenously For The Treatment Of Postoperative Pain
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Parecoxib and placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pre-intubation Chlorhexidine Oral Care on Health Outcomes
Status: COMPLETED
Conditions: Intratracheal Intubation|Surgery|Anesthesia
Interventions: OTHER: Oral care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Alternative Dosing Strategy of Ruxolitinib in Patients With Myelofibrosis
Status: COMPLETED
Conditions: Primary Myelofibrosis|Post-Polycythemia Vera Myelofibrosis|Post-Essential Thrombocythemia Myelofibrosis
Interventions: DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Portable Scalp Cooling System (PSCS) to Prevent Hair Loss for Breast Cancer Patients (Cooler Heads)
Status: RECRUITING
Conditions: Breast Cancer|Early-stage Breast Cancer|Hair Loss|Alopecia|Chemotherapy-induced Alopecia
Interventions: DEVICE: Amma Portable Scalp Cooling System (PSCS)|OTHER: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Two Mesh/Fixation Concepts for Laparoscopic Ventral and Incisional Hernia Repair
Status: TERMINATED
Conditions: Hernia, Abdominal|Hernia,Ventral
Interventions: PROCEDURE: Intraperitoneal onlay mesh (IPOM) repair with the use of Phisiomesh implant and Securestrap fixation device.|PROCEDURE: Intraperitoneal onlay mesh (IPOM) repair with the use of Ventralight ST implant with SorbaFix fixation device.|DEVICE: Ventralight ST implant|DEVICE: ETHICON PHYSIOMESH®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chymase Angiotensin-(1-12) Axis In Hypertensive Disease
Status: RECRUITING
Conditions: Hypertension
Interventions: OTHER: Determine the presence of Human sequence Ang-(1-12) on no medication|DRUG: Human sequence Ang-(1-12) on Lisinopril 40mg every day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Entacapone Combination With Imatinib for Treatment of GIST
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumor, Malignant
Interventions: DRUG: Entacapone|DRUG: Imatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gait Initiation and Transition From Double to Single Support in Patients With Unilateral Primary Coxarthrosis
Status: NOT_YET_RECRUITING
Conditions: Primary; Coxarthrosis
Interventions: OTHER: Patients with primary coxarthrosis (any stage).|OTHER: Patients with primary coxarthrosis (any stage) and operated with Total Hip Prosthesis (THP).|OTHER: Patients with primary coxarthrosis (any stage) and operated with RTH (Hip resurfacing).
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacy-based PrEP for Young Women Who Sell Sex in Zimbabwe
Status: RECRUITING
Conditions: Adherence, Medication|HIV Prevention
Interventions: BEHAVIORAL: Pharmacy-based PrEP refill and gift voucher|BEHAVIORAL: Control (Standard of care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Angiotensin II in Liver Transplantation
Status: RECRUITING
Conditions: Liver Transplant; Complications|Vasoplegia
Interventions: DRUG: Angiotensin II|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of IBI306 in HeFH Patients
Status: COMPLETED
Conditions: Heterozygous Familial Hypercholesterolemia
Interventions: DRUG: IBI306|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The ISLAND Study: InSuLa Assessed Needs for Depression
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Selective serotonin re-uptake inhibitor|BEHAVIORAL: Cognitive Behavioral Therapy|OTHER: Combination treatment (SSRI + CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Febuxostat, Blood Pressure and the Intrarenal Renin-Angiotensin System (RAS)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Febuxostat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective, Multi-Center Evaluation of Corneal Flap Creation Using Cheetah Femtosecond Laser System and Cheetah Patient Interface
Status: RECRUITING
Conditions: Refractive Error
Interventions: DEVICE: Cheetah femtosecond laser and Cheetah patient interface|DEVICE: IntraLase iFS iFS femtosecond laser and patient interface|DEVICE: Cheetah femtosecond laser and cheetah patient interface
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AngiographiC Evaluation of the Everolimus-Eluting Stent in Chronic Total Occlusions - the ACE-CTO Study
Status: COMPLETED
Conditions: Coronary Occlusions
Interventions: DEVICE: everolimus-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study Protocol - Debris Interventional Removal in ACS (DESIRE-ACS)
Status: UNKNOWN
Conditions: Coronary Disease|Acute Coronary Syndrome|Coronary Occlusion
Interventions: DEVICE: Bell Balloon Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety, Tolerability and Explore the Immunogenicity of EG-COVID and EG-COVARo in Healthy Adult Volunteers
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19 Vaccine
Interventions: DRUG: EG-COVID-003|DRUG: EG-COVID-001|DRUG: A: EG-COVID|DRUG: B: EG-COVID|DRUG: C: EG-COVARo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Adjunctive Use of Salvadora Persica in Chronic Periodontitis
Status: UNKNOWN
Conditions: Chronic Periodontitis
Interventions: DRUG: Salvadora Persica Root|PROCEDURE: Scaling and root planing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Eszopiclone With Mild to Moderate Obstructive Sleep Apnea Syndrome (OSAS)
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndrome
Interventions: DRUG: Eszopiclone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Time-limited Psychodynamic Psychotherapy and Informed Clinical Management in BPD High MHS Users
Status: COMPLETED
Conditions: Heavy MHS Use|General Psychopathology|Working Alliance
Interventions: OTHER: SB-APP|OTHER: treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Percutaneous Endovascular Aneurysm Repair (PEVAR) Trial
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: DEVICE: PEVAR (ProGlide closure)|DEVICE: SEVAR (IntuiTrak)|DEVICE: PEVAR (Prostar XL closure)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine, Abemaciclib and Endocrine Therapy in Hormone Receptor Positive (HR+)/Her 2 Negative Breast Cancer
Status: WITHDRAWN
Conditions: Solid Tumor|Advanced Breast Cancer
Interventions: DRUG: Abemaciclib|DRUG: Hydroxychloroquine 200 mg|DRUG: Faslodex|DRUG: Anastrazole|DRUG: Letrozole|DRUG: Hydroxychloroquine 400 mg|DRUG: Hydroxychloroquine 600 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of a Toothpaste to Reduce Sensitivity
Status: COMPLETED
Conditions: Dentin Hypersensitivity
Interventions: DRUG: Triclosan, Silicon dioxide, fluoride|DRUG: Triclosan, fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Efficacy and Safety of Octanorm in Patients With Dermatomyositis
Status: TERMINATED
Conditions: Dermatomyositis
Interventions: DRUG: Octanorm|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Aging and Individual Variation in Exercise Training Responsiveness
Status: NOT_YET_RECRUITING
Conditions: Prediabetic State|Cardiovascular Diseases|Insulin Resistance|Obesity
Interventions: BEHAVIORAL: Low/Mod|BEHAVIORAL: High/Mod|BEHAVIORAL: High/Vig
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Venlafaxine With or Without Zolpidem in Treating Hot Flashes and Associated Sleep Disorders in Women With Breast Cancer OR at High Risk for Developing Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Hot Flashes|Sleep Disorders
Interventions: DRUG: venlafaxine|DRUG: zolpidem tartrate|PROCEDURE: management of therapy complications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: AntiCD19 Chimeric Antigen Receptor T Cells for Relapsed or Refractory Non Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Hodgkin Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|BIOLOGICAL: CAR-T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of N-acetylcysteine in Preventing Cisplatin-Induced Toxicities in Cancer Patients
Status: RECRUITING
Conditions: Cisplatin Adverse Reaction|Cisplatin Nephrotoxicity|Cisplatin Induced Peripheral Neuropathy|Cancer Patients|Cisplatin Ototoxicity
Interventions: DRUG: N acetyl cysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of Remote Ischemic Conditioning Combined With Endovascular Thrombectomy for Acute Ischemic Stroke Due to Large Vessel Occlusion of Anterior Circulation
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: PROCEDURE: Remote ischemic conditioning|PROCEDURE: Sham remote ischemic conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Effectiveness Study on Cholesterol-reducing Activity
Status: COMPLETED
Conditions: Normal and Mild Hypercholesterolemic Subjects
Interventions: OTHER: 1 - low-fat dairy fermented product (drinkable) enriched with plant sterols (0,8g /day equivalent as free sterols).|OTHER: 2 - low-fat dairy fermented product (drinkable) enriched with plant sterols (1,6g /day equivalent as free sterols).|OTHER: 3 - low-fat dairy fermented product (drinkable) without plant sterols.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Collaborative Palliative and Oncology Care Model for Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: OTHER: Standard Leukemia Care|OTHER: Palliative Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Coffee Interaction With the Antihypertensive Drug Felodipine
Status: COMPLETED
Conditions: Food-Drug Interactions
Interventions: OTHER: Black Coffee|OTHER: Grapefruit Juice|OTHER: Water|DRUG: Felodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Autologous Bone Marrow Concentrate for the Treatment of Critical Limb Ischemia (CLI)
Status: COMPLETED
Conditions: Ischemia
Interventions: DEVICE: Harvest Smartprep2 BMAC System|DEVICE: SmartPReP2 BMAC System|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Evaluation of Tenofovir/Emtricitabine as HIV Pre-Exposure Prophylaxis in Transgender Women
Status: COMPLETED
Conditions: HIV Prevention
Interventions: DRUG: Tenofovir Disoproxil Fumarate/Emtricitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Valganciclovir for Treatment of Cytomegalovirus Infection in Solid Organ Transplant Patients
Status: COMPLETED
Conditions: Cytomegalovirus Infection
Interventions: DRUG: Single arm (ganciclovir and valganciclovir)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DNX-2401 With Interferon Gamma (IFN-γ) for Recurrent Glioblastoma or Gliosarcoma Brain Tumors
Status: COMPLETED
Conditions: Glioblastoma or Gliosarcoma
Interventions: DRUG: Single intratumoral injection of DNX-2401|DRUG: Interferon-gamma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Effect of MiboFlo in Dry Eye Patients
Status: COMPLETED
Conditions: Dry Eye Syndromes|Meibomian Gland Dysfunction
Interventions: DEVICE: MiBoFlo Thermoflo|PROCEDURE: forceful expression of the meibomian glands|DEVICE: LipiFlow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study to Evaluate the Effects of CTP-543 on the QT/QTc Intervals in Health Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: CTP-543|DRUG: CTP-543|DRUG: Moxifloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: An Open-label Study to Evaluate Topiramate Therapy in Migraine Patients, and Its Effects on Subject Responsiveness to Migraine Treatment With Triptans
Status: COMPLETED
Conditions: Headache
Interventions: DRUG: topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: iGlarLixi vs IDegAsp in Chinese Participants After OAD(s)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Insulin glargine/Lixisenatide|DRUG: IDegAsp|DRUG: Metformin|DRUG: SGLT2 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transition to Peginterferon Beta-1a (BIIB017) From Subcutaneous Interferon Therapy
Status: WITHDRAWN
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: Interferon Beta|DRUG: BIIB017 (Peginterferon beta-1a)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Time to Cardiovascular Event Analysis Comparing Tocilizumab to Other Biologics in Patients With Rheumatoid Arthritis (RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Other Biologics|DRUG: Tocilizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Radiocontrast Media in the Pulsed Radiofrequency Treatment
Status: UNKNOWN
Conditions: Lumbar Radiculopathy|Pain, Intractable
Interventions: PROCEDURE: Pulsed Radiofrequency treatment of the lumbar dorsal root ganglion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Autologous Mesenchymal Stem Cells and Mononuclear Cells on Diabetic Critical Limb Ischemia and Foot Ulcer
Status: COMPLETED
Conditions: Autologous Transplantation|Diabetic Foot
Interventions: BIOLOGICAL: Symptoms and Objective Examination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enteroaggregative E.Coli (EAEC)
Status: TERMINATED
Conditions: Escherichia Coli Infections
Interventions: DRUG: Levofloxacin|DRUG: Placebo|BIOLOGICAL: Enteroaggregative E. coli (EAEC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: A Study to Examine the Implantation Characteristics of Two Drug-Eluting Stents
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Coronary Stent Cypher|DEVICE: Coronary stent Xience
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3541860 in Adult Participants With Relapsing Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: LY3541860|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CPX-351 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Adult Acute Erythroid Leukemia (M6)|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia and Acute Monocytic Leukemia (M5)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|de Novo Myelodysplastic Syndromes|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Myeloid Leukemia|Secondary Myelodysplastic Syndromes
Interventions: DRUG: liposomal cytarabine-daunorubicin CPX-351
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of XmAb®22841 Monotherapy & in Combination w/ Pembrolizumab in Subjects w/ Selected Advanced Solid Tumors
Status: COMPLETED
Conditions: Melanoma|Cervical Carcinoma|Pancreatic Carcinoma|Triple Negative Breast Cancer|Hepatocellular Carcinoma|Urothelial Carcinoma|Squamous Cell Carcinoma of the Head and Neck|Nasopharyngeal Carcinoma|Renal Cell Carcinoma|Non-small Cell Lung Carcinoma|Small Cell Lung Carcinoma|Gastric or Gastroesophageal Junction Adenocarcinoma|Advanced or Metastatic Solid Tumors|Prostate Carcinoma|Epithelial Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Carcinoma|Intrahepatic Cholangiocarcinoma|Squamous Cell Anal Cancer|Squamous Cell Penile Carcinoma|Squamous Cell Vulvar Carcinoma|Colorectal Carcinoma|Endometrial Carcinoma
Interventions: BIOLOGICAL: XmAb®22841|BIOLOGICAL: Pembrolizumab (Keytruda®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Pharmacokinetics, Pharmacodynamics, Safety, Tolerability, and Immunogenicity of Biosimilar Denosumab With Prolia® in Healthy Adult Male Volunteers
Status: RECRUITING
Conditions: Healthy Male Subjects
Interventions: BIOLOGICAL: ENZ215|BIOLOGICAL: EU Sourced Prolia|BIOLOGICAL: US Sourced Prolia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Computed Tomography (CT) for Evaluation of Coronary Artery Blockages in Typical or Atypical Chest Pain
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: 64 Channel VCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence Study Comparing Linezolid 600 Mg Oral Suspension With 600 Mg Tablet In Chinese Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Linezolid|DRUG: Linezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Impact of the DROP Program on the DRP (Drug Related Problems) Related to Oral Anticancer Drugs in Ambulatory Patients With Risk Factors
Status: UNKNOWN
Conditions: Cancer
Interventions: BEHAVIORAL: The DROP program of pharmaceutical interventions|BEHAVIORAL: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: BOOM-IBD2 to Evaluate the Sacral Neuromodulation in IBD Patients
Status: NOT_YET_RECRUITING
Conditions: Ulcerative Colitis|Inflammatory Bowel Diseases
Interventions: DEVICE: Neuromodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise With or Without Electrical Stimulation in Cystic Fibrosis (Part I): Effects on Physical Fitness
Status: COMPLETED
Conditions: Cystic Fibrosis in Children
Interventions: BEHAVIORAL: Exercise-NMES|BEHAVIORAL: Exercise-No NMES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Verbal Cueing vs Constraint-Led Approach for Teaching the Kettlebell Swing
Status: COMPLETED
Conditions: Movement Disorders|Muscle Tenderness
Interventions: BEHAVIORAL: Verbal coaching vs. Constraint based coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT