pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Neck Surgery in Treating Patients With Early-Stage Oral Cancer
Status: UNKNOWN
Conditions: Head and Neck Cancer
Interventions: OTHER: questionnaire administration|PROCEDURE: psychosocial assessment and care|PROCEDURE: quality-of-life assessment|PROCEDURE: regional lymph node dissection|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Surgery With or Without Docetaxel and Leuprolide or Goserelin in Treating Patients With High-Risk Localized Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: docetaxel|DRUG: LHRH agonist|PROCEDURE: surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Phosphatidylserine-Omega3 in Elderly With Age Associated Memory Impairment
Status: COMPLETED
Conditions: Age Associated Memory Impairment
Interventions: DIETARY_SUPPLEMENT: PS-Omega3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes From Enhanced SCREENing Strategies for NASH in Type 2 Diabetes (SCREEN NASH T2D)
Status: RECRUITING
Conditions: Nonalcoholic Steatohepatitis|Type 2 Diabetes
Interventions: OTHER: routine screening|OTHER: physician-driven screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Minimally Invasive Surfactant Therapy Followed by CPAP (MISTCPAP) in Preterm Infants With RDS
Status: UNKNOWN
Conditions: Respiratory Distress Syndrome
Interventions: DRUG: Surfactant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Dose Trial of VMX-C001 in Healthy Subjects With and Without FXa Direct Oral Anticoagulant
Status: ACTIVE_NOT_RECRUITING
Conditions: Coagulation Disorder
Interventions: DRUG: VMX-C001|DRUG: Placebo|DRUG: Rivaroxaban 20 mg Oral Tablet|DRUG: Apixaban 5 mg Oral Tablet|DRUG: Edoxaban 60 mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rifaximin for Functional Dyspepsia
Status: COMPLETED
Conditions: Functional Dyspepsia
Interventions: DRUG: Rifaximin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Brain Stimulation Normalizes Dopaminergic Transmission in the Frontostriatal Circuit to Alleviate Depression With Metabolic Disorders.
Status: UNKNOWN
Conditions: Depression
Interventions: DEVICE: Repetitive transcranial magnetic stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of FDY-5301 in Major Trauma Patients in ICU
Status: TERMINATED
Conditions: ICU Acquired Weakness
Interventions: DRUG: FDY-5301|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: AV Nodal Reentrant Tachycardia Study
Status: COMPLETED
Conditions: Tachycardia, Atrioventricular Nodal Reentry
Interventions: PROCEDURE: Cardiac Invasive Electrophysiological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Unresectable Hepatocellular Carcinoma
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methotrexate in the Treatment of Chronic Idiopathic Urticaria
Status: COMPLETED
Conditions: Chronic Urticaria
Interventions: DRUG: Methotrexate (Novatrex ®) + anti-H1|DRUG: Placebo + anti-H1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Delayed Cord Clamping in Very Low Birth Weight Infants
Status: COMPLETED
Conditions: Bronchopulmonary Dysplasia|Necrotizing Enterocolitis|Intraventricular Hemorrhage|Late Onset Neonatal Sepsis|Motor Skills Disorders
Interventions: PROCEDURE: delayed cord clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Aerobic vs Core Stability Exercise Training Program in Women With Endometriosis
Status: COMPLETED
Conditions: Endometriosis
Interventions: OTHER: aerobic exercises|OTHER: core stability exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Calcium and Vitamin D to Optimize Bone Mass in Boys With Risperidone-induced Hyperprolactinemia
Status: COMPLETED
Conditions: Risperidone-induced Hyperprolactinemia
Interventions: DRUG: Calcium and Vitamin D|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison Between Laser, Synthetic Gel and Herbal Gel as Topical Agents After Gum Surgery
Status: COMPLETED
Conditions: Gingival Overgrowth
Interventions: PROCEDURE: External bevel gingivectomy|DEVICE: Diode laser Biostimulation|OTHER: Hyaluronic acid (Gengigel) topical application.|OTHER: Herbal gel (Hiora SG) topical application
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Algorithm for Apherisis Monitoring and Prescription Assistance in Sickle Cell Patients (ALGODREP)
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DEVICE: Algodrep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Early Use of Nitazoxanide in Patients With COVID-19
Status: COMPLETED
Conditions: Covid19|Coronavirus
Interventions: DRUG: Nitazoxanide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Neuropathic Pain Caused by Radiation Therapy
Status: COMPLETED
Conditions: Neuropathic Pain Secondary to Radiation Therapy
Interventions: DRUG: topical amitriptyline 2%, ketamine 1%, and lidocaine 5% in pluronic lecitine organogel(AKL in PLO gel)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Graft Selection in Anatomic Anterior Cruciate Ligament Reconstruction
Status: RECRUITING
Conditions: Anterior Cruciate Ligament Injuries
Interventions: PROCEDURE: Hamstring tendon autograft|PROCEDURE: Pattella tendon autograft|PROCEDURE: Quadriceps tendon autograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venetoclax+HMA+Aclarubicin Versus Venetoclax+HMA in Treatment-Naive Elderly Patients With AML
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Venetoclax-Decitabine/Azacitidine-Aclarubicin Association|DRUG: Venetoclax-Decitabine/Azacitidine Association
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treating Nicotine Dependence in Schizophrenic Individuals: Effectiveness of Bupropion - 1
Status: COMPLETED
Conditions: Tobacco Use Cessation|Tobacco Use Disorder|Schizophrenia
Interventions: DRUG: Bupropion|DRUG: nicotine transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating Safety of Chronic Therapy With Certolizumab Pegol in Crohn's Disease
Status: WITHDRAWN
Conditions: Crohn's Disease
Interventions: DRUG: Certolizumab pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mental Health of Professionals of the Silver Economy of New Aquitaine : Online Survey of Accommodation Establishments for Old People and Home Assistance Establishments
Status: NOT_YET_RECRUITING
Conditions: COVID-19 Pandemic|Professional Stress
Interventions: OTHER: Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Transcranial Direct Current Stimulation in Autism Spectrum Disorder
Status: COMPLETED
Conditions: Transcranial Direct Current Stimulation|Autistic Disorders Spectrum|Electroencephalography
Interventions: DEVICE: Active-tDCS|DEVICE: Sham-tDCS|OTHER: Wait-list
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PrEP Seguro: Antiretroviral-based HIV Prevention Among Men at High Risk in Mexico
Status: COMPLETED
Conditions: HIV Infections
Interventions: BEHAVIORAL: Conditional Economic Incentive (CEI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sofosbuvir Plus Ribavirin in Treatment-Naive and Treatment-Experienced Egyptian Adults With Chronic Genotype 4 Hepatitis C Virus (HCV) Infection
Status: COMPLETED
Conditions: Hepatitis C Virus
Interventions: DRUG: SOF|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analysis of Volatile Organic Compounds in Exhaled Air and in Sweat in the Context of Suspicion of COVID-19 Infection
Status: COMPLETED
Conditions: Covid19
Interventions: DEVICE: Volatile Organic Compounds analysis|OTHER: Canine odor detection of Volatile Organic Compounds
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A GnRH Agonist IN Pre-menopausal Women STudy to Treat Severe Polycystic Liver Disease
Status: RECRUITING
Conditions: Polycystic Liver Disease|Autosomal Dominant Polycystic Kidney
Interventions: DRUG: Leuprorelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pecs II Block as Alternative for Paravertebral Block in Modified Radical Mastectomy
Status: UNKNOWN
Conditions: Modified Radical Mastectomy
Interventions: OTHER: Thoracic Paravertebral group|OTHER: Pecs II group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of EUS-Guided Fine Needle Aspiration Technique
Status: UNKNOWN
Conditions: EUS-FNA|Cytodiagnosis
Interventions: PROCEDURE: EUS-FNA|DEVICE: Echoendoscope Olympus GF-UCT240
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Early Intervention vs. Standard Palliative Care in Improving End-of-Life Care in Advanced Cancer Patients
Status: COMPLETED
Conditions: Cancer
Interventions: OTHER: counseling intervention|OTHER: educational intervention|PROCEDURE: psychosocial assessment and care|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Aromatherapy Inhaler Use for HSCT Distress
Status: NOT_YET_RECRUITING
Conditions: Cancer Distress|Cancer Coping|Hematopoetic Stem Cell Transplant|Aromatherapy
Interventions: OTHER: Aromatherapy Inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Quetiapine for Mania In Preschool Children 4 to 6 Years of Age With Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder|Mania
Interventions: DRUG: quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on SyB L-0501 in Patients With Indolent B-cell Non-Hodgkin's Lymphoma or Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma|Mantle Cell Lymphoma
Interventions: DRUG: bendamustine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurophysiological Measurements Using the NeuroCatch™ Platform in Pediatric Concussion
Status: UNKNOWN
Conditions: Children, Only|Traumatic Brain Injury|Concussion, Mild|Pediatric ALL
Interventions: DEVICE: NeuroCatch™ Platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Drug Drug Interaction Study for EYP001 With Entecavir
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: EYP001|DRUG: Entecavir 1 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy in Type 2 Diabetic Patients With Severe Chronic Renal Impairment, 5 mg BI 1356 (Linagliptin) vs. Placebo, Insulin Background Inclusive
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: BI 1356|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect and Essentiality of Vertebroplasty Surgery in Acute Vertebral Compression Fractures
Status: UNKNOWN
Conditions: Spinal Fractures
Interventions: PROCEDURE: percutaneous vertebroplasty|PROCEDURE: conservative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dry Needling vs Injection in Patients With Temporomandibular Disorders
Status: RECRUITING
Conditions: Temporomandibular Disorders
Interventions: PROCEDURE: Dry needling and placebo injection|PROCEDURE: Injection and placebo dry needling|PROCEDURE: Dry needling and injection|PROCEDURE: Placebo dry needling and placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Sugira Muryango PLAY Collaborative
Status: ACTIVE_NOT_RECRUITING
Conditions: Child Development|Parenting|Parent-Child Relations|Child Malnutrition
Interventions: OTHER: Sugira Muryango
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Novel Photosensitizer in The Treatment of Chronic Periodontitis
Status: UNKNOWN
Conditions: Periodontitis|Alveolar Bone Loss
Interventions: DRUG: Phthalocyanine Dye|DRUG: LASER assisted SRP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First in Human Study of TORL-1-23 in Participants With Advanced Cancer
Status: RECRUITING
Conditions: Advanced Solid Tumor|Ovarian Cancer|Endometrial Cancer|NSCLC
Interventions: DRUG: TORL-1-23
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PPA Tele-Savvy: A Pilot Study of an Online Intervention for Caregivers of Persons Living With PPA
Status: COMPLETED
Conditions: Primary Progressive Aphasia|Caregiver Burnout
Interventions: BEHAVIORAL: PPA Tele-Savvy Pilot Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Single Site Safety and Tolerability Study of HBOC-201 in Trauma Subjects
Status: UNKNOWN
Conditions: Wounds and Injuries
Interventions: DRUG: Hemoglobin-based oxygen carrier-201 (HBOC 201)|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Design of a Model to Study Functionality of the Trigeminal Nerve in Relation to Controlled Nasal Fractures
Status: UNKNOWN
Conditions: Fracture of Nasal Bones, Sequela
Interventions: DEVICE: Cold dry air machine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Inspiratory Muscle Training on Obstructive Sleep Apnea Syndrome
Status: COMPLETED
Conditions: Inspiratory Muscle Training|Obstructive Sleep Apnea
Interventions: DEVICE: Inspiratory muscle training with powerbreathe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: APOLLO-B: A Study to Evaluate Patisiran in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR Amyloidosis With Cardiomyopathy)
Status: ACTIVE_NOT_RECRUITING
Conditions: Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
Interventions: DRUG: Placebo|DRUG: Patisiran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Amitriptyline for Repetitive Behaviors in Autism Spectrum Disorders
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Repetitive Compulsive Behavior
Interventions: DRUG: amitriptyline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Demonstrate the Relative Bioavailability of Geneva and Basel (Anafranil) 25 mg Clomipramine Hydrochloride Capsules Under Fasted Conditions
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Clomipramine Hydrochloride 25 mg Capsules (Geneva Pharmaceuticals)|DRUG: Anafranil Clomipramine Hydrochloride 25 mg Capsules (Basel)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Boosting the Secretion of GLP-2 and GLP-1 Intestinal Hormones by Nutrients
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: meal intake|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Trial Investigating the Combination Therapy With Luminor DCB and iVolution Stent in TASC C and D Femoropopliteal Lesions
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: Combination therapy DCB + stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact on T Cell Immune Activation and Inflammation of Triptolide Woldifii in HIV-infected Immunological Non-responders
Status: UNKNOWN
Conditions: HIV
Interventions: DRUG: Triptolide|DRUG: cART|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Brodalumab in Subjects With Axial Spondyloarthritis (axSpA)
Status: COMPLETED
Conditions: Axial Spondyloarthritis
Interventions: DRUG: Brodalumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease (TED)
Status: WITHDRAWN
Conditions: Thyroid Eye Disease
Interventions: DRUG: ASTED|DIETARY_SUPPLEMENT: Selenium|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the Universal Neonatal Foot Orthosis in the Treatment of Metatarsus Adductus (MTA)
Status: UNKNOWN
Conditions: Metatarsus Adductus|Metatarsus Varus
Interventions: DEVICE: UNFO-s|PROCEDURE: cast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Symptom-driven ICS/LABA Therapy for Adolescent Patients With Asthma Non-adherent to Daily Maintenance Inhalers
Status: RECRUITING
Conditions: Asthma in Children|Nonadherence, Medication
Interventions: DRUG: Maintenance ICS and Symptom Driven SABA|DRUG: Symptom-driven budesonide/formoterol combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Mayo Clinic Upper Digestive Disease Survey
Status: RECRUITING
Conditions: Esophageal Neoplasms|Cancer of Esophagus|Cancer of the Esophagus|Esophageal Cancer|Esophagus Cancer|Neoplasm, Esophageal|Esophagectomy|Abnormalities, Digestive System|Digestive System Abnormalities
Interventions: OTHER: Mayo Clinic Upper Digestive Disease Survey on Paper|OTHER: Upper Digestive Disease (UDD Monitor) App
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open-label, Single Arm Trial of BI 695502 in Patients With Previously Untreated Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: DRUG: BI 695502|DRUG: Avastin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-marketing Safety Study in Participants of All Pathologies Who Receive Gadolinium-Based Contrast Agents (GBCAs) for Contrast-Enhanced Magnetic Resonance Imaging (MR) Examination
Status: COMPLETED
Conditions: Magnetic Resonance Imaging (MRI)
Interventions: DRUG: Clariscan|OTHER: Gadolinium-Based Contrast Agents
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lapatinib With Sirolimus or Metformin
Status: COMPLETED
Conditions: Advanced Cancers
Interventions: DRUG: Lapatinib|DRUG: Sirolimus|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Diabetic Polyneuropathy (Stage 1 or 2)
Status: COMPLETED
Conditions: Diabetic Polyneuropathy
Interventions: DRUG: Thioctic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study to Investigate Mycophenolic Acid (MPA) Exposure Through Area Under the Curve (AUC) in Renal Transplants Recipients Treated With Mycophenolate Mofetil (MMF) and After Conversion to Mycophenolate Sodium (EC-MPS)
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: Mycophenolate sodium|DRUG: Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Can Enhanced Glycemic Control in Type II Diabetics Improve Myocardial Protection During Coronary Artery Bypass Grafting?
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: Glucose potassium insulin solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevalence and Malignant Involvement of Calcified Intrathoracic Lymph Nodes in Patients Undergoing Endosonography
Status: COMPLETED
Conditions: Lymphadenopathy|Lung Cancer|Sarcoidosis|Tuberculosis
Interventions: DEVICE: Endosonography B-mode examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial to Evaluate AB011 Injection in Patients With CLDN18.2-positive Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor|Gastric Cancer|Pancreatic Adenocarcinoma
Interventions: DRUG: AB011 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety/Tolerability in Portuguese Participants With RRMS Transitioning From Current Therapy
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: peginterferon beta-1a|DRUG: interferon beta-1a|DRUG: interferon beta-1b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yttrium-90 (TARE-Y90) in Children, Adolescents, and Young Adults With Liver Tumors
Status: TERMINATED
Conditions: Hepatoblastoma|Hepatocellular Carcinoma|Rhabdoid Tumor of Liver|Undifferentiated (Embryonal) Sarcoma of the Liver|Pediatric Liver Cancer|Liver Tumors
Interventions: BEHAVIORAL: Quality of Life Assessment|RADIATION: Transarterial Radioembolization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metformin Treatment of Patients With Hand Osteoarthritis
Status: RECRUITING
Conditions: Hand Osteoarthritis
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PDD vs PAD to Treat Initially Diagnosed MM
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: PDD regimen: doxorubicin hydrochloride iposome, bortizomib and dexamethasone|DRUG: PAD regimen: bortizomib, dexamethasone and doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NGA-01 Gel for the Treatment of Osteoarthritis With Joint Pain
Status: COMPLETED
Conditions: Arthritis Osteoarthritis
Interventions: OTHER: NGA-01 gel|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-Invasive Ventilation Via a Helmet Device for Patients Respiratory Failure
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome|Shock|Ventilatory Failure|Cardiogenic Pulmonary Edema
Interventions: DEVICE: Non invasive ventilation using a helmet hyperbaric device|OTHER: Noninvasive ventilation via facemask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy Treatment During Radiation Therapy for Superior Sulcus Non-small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Lung Non-Small Cell Carcinoma|Stage IIB Lung Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8|Superior Sulcus Lung Carcinoma
Interventions: BIOLOGICAL: Atezolizumab|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Carboplatin|DRUG: Cisplatin|PROCEDURE: Computed Tomography|DRUG: Etoposide|RADIATION: External Beam Radiation Therapy|PROCEDURE: Magnetic Resonance Imaging|DRUG: Paclitaxel|DRUG: Pemetrexed|PROCEDURE: Positron Emission Tomography|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crossover Trial to Assess Efficacy and Safety of Inhaled AQ001S Compared to a Budesonide Suspension in Mild Asthmatics
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: AQ001S 0.125 mg/ml|DRUG: Budesonide 0.125 mg/ml inhalation suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Normal Saline With or Without Dextrose During Induction of Labor in Nulliparous
Status: COMPLETED
Conditions: Delivery Uterine
Interventions: OTHER: 5% dextrose|OTHER: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Evaluation of the Effectiveness and Safety of Vibro-acoustic Pulmonary Therapy (VAPT) in Complex Therapy for Acute Respiratory Failure of Mixed Type I-II Stages in Comparison With Percussion Massage in Cardiac Surgical Patients in the Early Postoperative Period
Status: RECRUITING
Conditions: Cardiac Surgical Patients (CABG,Mammary Coronary Bypass Surgery,Plastic and Replacement of Valves, Atrial Septal Defect,Ventricular Septal Defect)
Interventions: DEVICE: Vibroacoustic device BARK VibroLUNG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SeMaglutide and Albuminuria Reduction Trial in Obese Individuals Without Diabetes
Status: COMPLETED
Conditions: Obesity|Albuminuria
Interventions: DRUG: Semaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of a Formulation Containing Phtalox® in Periodontal Disease
Status: RECRUITING
Conditions: Periodontal Diseases|Periodontitis|Bone Loss
Interventions: OTHER: Scraping and straightening of the crown and root and rinsing with mouthwashes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Prehabilitation for Patients Undergoing Lumbar Spinal Stenosis Surgery
Status: UNKNOWN
Conditions: Lumbar Spinal Stenosis|Prehabilitation
Interventions: OTHER: 6-week prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Virtual Reality and Distraction Cards on Pain
Status: COMPLETED
Conditions: Smear Layer|Cervical Cancer
Interventions: OTHER: Virtual Reality (VR)|OTHER: Distraction Cards Practice Group|OTHER: Virtual Reality (VR) Breathing Exercise Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Counseling Conditions for Buprenorphine in a Primary Care Clinic - 1
Status: COMPLETED
Conditions: Heroin Dependence|Opioid-Related Disorders|Substance Abuse, Intravenous
Interventions: DRUG: Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Inulin and Acetate Production and Human Substrate Metabolism
Status: COMPLETED
Conditions: Obesity|Pre Diabetes
Interventions: DIETARY_SUPPLEMENT: Inulin and Resistant Starch|DIETARY_SUPPLEMENT: Inulin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Antidepressant Response in the Treatment of Depressive Symptoms and Frailty Characteristics in Older Adults
Status: COMPLETED
Conditions: Major Depressive Disorder|Dysthymic Disorder|Depressive Disorder, NOS
Interventions: DRUG: Antidepressant Medication
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation Drug-drug Interaction Between Dabigatran and Clarithromycin
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Dabigatran then dabigatran and clarithromycin|DRUG: Clarithromycin and dabigatran then dabigatran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Clinical Study to Investigate the Effects of Dapagliflozin on Heart Work, Heart Nutrient Uptake, and Heart Muscle Efficiency in Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: dapagliflozin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Weight Loss and Exercise To Improve Rheumatoid Arthritis Cardiovascular Risk
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: OTHER: SWET: Supervised Weight loss and Exercise Training|OTHER: CHAT: Counseling Health As Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intramuscular Depot Formulation of Aripiprazole as Maintenance Treatment in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Aripiprazole depot|DRUG: Placebo depot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Salvage Radiation Treatment After B-cell Maturation Antigen Chimeric Antigen Receptor T-cell Therapy for Relapsed Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma|Plasma Cell Neoplasm|Malignant Plasma Cell Neoplasm
Interventions: DRUG: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nudging Flu Vaccination in Patients at Moderately High Risk for Flu and Flu-related Complications
Status: COMPLETED
Conditions: Influenza|Vaccination|Health Promotion|Health Behavior|Risk Reduction
Interventions: BEHAVIORAL: Risk Reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Study of Lobaplatin，5-Fluorouracil and Leucovorin for the Treatment of Esophageal Carcinoma
Status: UNKNOWN
Conditions: Esophageal Carcinoma
Interventions: DRUG: lobaplatin , 5-FU ,leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Full-mouth Periodontal Debridement and Metronidazole Gel in Patients With Chronic Periodontitis
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: PROCEDURE: Full-mouth periodontal debridement|DRUG: Metronidazole tablet|DRUG: placebo gel|DRUG: Metronidazole benzoate gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Emotional Intelligence Program for Adolescents With Antisocial Behavior (DYNAMIS)
Status: COMPLETED
Conditions: Mental Health Wellness 1
Interventions: BEHAVIORAL: The program comprises 12 sessions and additional activities to be carried out after each session, alongside counseling from the program's leading professionals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assess the Safety, Tolerability, and Pharmacokinetic (PK) Characteristics of HM10460A (HNK460) in Healthy Adult Korean Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HM10460A 5μg/kg|DRUG: HM10460A 15μg/kg|DRUG: HM10460A 45μg/kg|DRUG: HM10460A 135μg/kg|DRUG: HM10460A 350μg/kg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Trial of Regorafenib in Patients With Recurrent Ovarian, Primary Peritoneal and Fallopian Tube Cancer
Status: TERMINATED
Conditions: Ovarian Cancer|Primary Peritoneal Cancer|Fallopian Tube Cancer
Interventions: DRUG: regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Improve Lung Function and Symptoms for Emphysema Patients Using Zephyr Valves
Status: COMPLETED
Conditions: COPD|Heterogeneous Emphysema
Interventions: DEVICE: ELVR (Endoscopic Lung Volume Reduction) with Zephyr Valves
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Scalp Nerve Block on Emergence Agitation
Status: COMPLETED
Conditions: Agitation
Interventions: DRUG: Ropivacaine|DRUG: Remifentanil|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Right VEntricular Contractile ReSERVE in Functional Tricuspid Regurgitation
Status: UNKNOWN
Conditions: Functional Tricuspid Regurgitation
Interventions: DIAGNOSTIC_TEST: Stress Echocardiography|DIAGNOSTIC_TEST: Pressure volume loop analysis|PROCEDURE: Tricuspid valve repair or replacement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Feeding Infant Formula With Enriched Protein Fractions
Status: COMPLETED
Conditions: Cognitive Ability, General
Interventions: DIETARY_SUPPLEMENT: Enriched Protein Fractions|DIETARY_SUPPLEMENT: Protein Fractions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Glucosamine on Intraocular Pressure
Status: UNKNOWN
Conditions: Intraocular Pressure Changes After Glucosamine Sulfate Consumption.
Interventions: DRUG: Placebo three times a day|DRUG: glucosamine sulfate 1500 mg three times a day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Drug-Drug Interaction Study With Pravastatin and Cyclosporine
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pravastatin alone|DRUG: Pravastatin and Cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Standard of Care Versus Hemopatch® During Liver Resection
Status: UNKNOWN
Conditions: Liver Cancer|Hemorrhage Liver|Bile Leak|Surgery|Tumor Liver
Interventions: OTHER: Hemopatch|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Intravenous Sodium Bicarbonate Verifies Intravenous Position of Catheters in Children
Status: COMPLETED
Conditions: Verifying the Correct Position of Intravenous Catheters
Interventions: DEVICE: intravenous sodium bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Testing the Combination of Two Immunotherapy Drugs (Magrolimab and Dinutuximab) in Patients With Relapsed or Refractory Neuroblastoma or Relapsed Osteosarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: High Risk Neuroblastoma|Recurrent Neuroblastoma|Recurrent Osteosarcoma|Refractory Neuroblastoma|Resectable Osteosarcoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Computed Tomography|BIOLOGICAL: Dinutuximab|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Magrolimab|PROCEDURE: Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SARC016: Study of Everolimus With Bevacizumab to Treat Refractory Malignant Peripheral Nerve Sheath Tumors
Status: COMPLETED
Conditions: Malignant Peripheral Nerve Sheath Tumors|MPNST|Sarcoma
Interventions: DRUG: everolimus|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of DISC-0974 to Assess the Safety, Tolerability, PK and PD of DISC-0974 in Participants With CKD and Anemia
Status: RECRUITING
Conditions: Chronic Kidney Diseases|Anemia of Chronic Kidney Disease
Interventions: DRUG: DISC-0974|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Methoxy Polyethylene Glycol-Epoetin Beta (Mircera) for the Treatment of Chronic Renal Anemia in Participants With Diabetic Nephropathy
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Methoxy polyethylene glycol-epoetin beta [Mircera]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Phase lB/II Study of Glofitamab and Atezolizumab or Polatuzumab Vedotin in Adult Patients With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Hodgkins Lymphoma
Interventions: DRUG: Glofitamab|DRUG: Atezolizumab|DRUG: Obinutuzumab|DRUG: Tocilizumab|DRUG: Polatuzumab Vedotin|DRUG: 89Zr-Df-IAB22M2C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interdisciplinary + Intersectoral Telemedicine Evaluation, Coordination + Treatment in RhineMain+ Parkinson's Network
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: OTHER: New Intervention form including|OTHER: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Improving Health Outcomes in Young Cisgender Men and Transgender Women (mLab App)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DEVICE: mLab App|BEHAVIORAL: HIV Prevention Information|DEVICE: HIV Home Tests
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study Evaluating the Performance and Safety of Global D Implants Indicated for Orthognathic Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Orthognathic Surgery|Maxillofacial Abnormalities|Maxilla Fracture
Interventions: DEVICE: Orthognathic surgery using Global D's implants.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Simultaneous Treatment Regimen Compared to a Sequential Treatment Regimen With Ingenol Mebutate Gel 0.015% and 0.05% of Two Areas With Actinic Keratosis on Face/Scalp and Trunk/Extremities
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Ingenol mebutate gel 0.05 %|DRUG: Ingenol mebutate gel 0.015 %
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Apixaban Sprinkle Compared to Apixaban Capsules
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Drug: Apixaban sprinkle capsules|DRUG: Experimental: Apixaban tablets followed by apixaban sprinkle capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Exparel for Postoperative Analgesia Following Bariatric Surgery
Status: UNKNOWN
Conditions: Post Operative Pain
Interventions: DRUG: Exparel 266 MG Per 20 ML Injection|DRUG: Bupivacaine Hcl 0.25% Inj
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CPAP Improving Mortality for Pneumonia in African Children Trial
Status: TERMINATED
Conditions: Pneumonia|Human Immunodeficiency Virus (HIV)|Malnutrition|Hypoxemia
Interventions: DEVICE: bubble continuous positive airway pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of PPG & PAT to Detect Upper Airway Obstruction in Patients With Obstructive Sleep Apnea
Status: UNKNOWN
Conditions: Sleep Apnea, Obstructive
Interventions: DEVICE: Measurement of PPG waveforms|DEVICE: Measurement of Pulse Arrival Time (PAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation (AF)|Stroke
Interventions: BIOLOGICAL: Abelacimab|DRUG: Rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Surgery Followed by Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: PROCEDURE: conventional surgery|RADIATION: brachytherapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Dose-escalation Safety Trial for Intrathecal Autologous Mesenchymal Stem Cell Therapy in Amyotrophic Lateral Sclerosis
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: BIOLOGICAL: autologous mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-intensity Shockwaves Therapy for the Treatment of Patients With Moderate Vasculogenic Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DEVICE: Dornier Aries2 device|DEVICE: Dornier Aries2 device (sham probe)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT