pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy, Safety, and Tolerability of Multiple Dosing Regimens of Oral Atogepant (AGN-241689) in Episodic Migraine Prevention
Status: COMPLETED
Conditions: Migraine, With or Without Aura
Interventions: DRUG: Atogepant|DRUG: Placebo-matching Atogepant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: 8 Weeks Study to Evaluate the Efficacy and Safety of Valsartan in Combination With Aliskiren Compared to Valsartan Alone in Patients With Stage 2 Hypertension
Status: COMPLETED
Conditions: Stage 2 Hypertension
Interventions: DRUG: Valsartan/aliskiren|DRUG: Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Immune Response Activation for the Treatment of Unresectable Metastatic Colorectal Cancer or CEA Positive Metastatic Breast Cancer
Status: RECRUITING
Conditions: Breast Carcinoma|Colorectal Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|DRUG: Immunotherapy|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Beetroot Juice on Isometric Knee Extension Strength, Explosive Strength and Local Muscular Endurance
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DIETARY_SUPPLEMENT: Beetroot juice concentrate (140 ml)|DIETARY_SUPPLEMENT: Blackcurrant juice (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Cytokine and Body Composition's Changes in Overweight/Obese Women
Status: UNKNOWN
Conditions: Maternal Obesity Complicating Pregnancy|Exercise Addiction|High-Risk Pregnancy|Inflammatory Status During Preganancy|Maternal Body Composition
Interventions: BEHAVIORAL: Lifestyle change program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A 52-Week Study to Learn About the Safety and Effects of Ritlecitinib in Participants With Nonsegmental Vitiligo
Status: RECRUITING
Conditions: Vitiligo
Interventions: DRUG: Ritlecitinib|DRUG: Ritlecitinib 100 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intervention for Reduced Sound Tolerance
Status: COMPLETED
Conditions: Hyperacusis
Interventions: OTHER: Sound Therapy (Tinnitus Retraining Therapy)|OTHER: Counseling (Tinnitus Retraining Therapy)|OTHER: No Counseling|OTHER: Placebo Sound Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Treatment for TMJ Arthralgia
Status: RECRUITING
Conditions: TMJ Pain
Interventions: DRUG: Hydrocortisone 2.5%|DRUG: Diclofenac 1% topical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Engagement of coMmunity Through Participatory Learning and Action for cOntrol and preVEntion of Type II Diabetes and Its Risk Factors [EMPOWER-D]
Status: NOT_YET_RECRUITING
Conditions: Type II Diabetes Mellitus|Intermediate Hyperglycemia (IHG)
Interventions: BEHAVIORAL: Participatory, Learning and Action Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Gleevec Trial in Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia
Interventions: DRUG: Gleevec
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sustainable and Healthy Return-to-Work Program - PRATICAdr 2.0
Status: NOT_YET_RECRUITING
Conditions: Common Mental Disorder
Interventions: BEHAVIORAL: Return to work coordinator + PRATICAdr 2.0|BEHAVIORAL: Return to work coordinator only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Colloid Pre-Loading on D-Dimer During Cesarean Section Under Spinal Anesthesia
Status: COMPLETED
Conditions: Coagulation Defect; Bleeding
Interventions: DRUG: hydroxyethyl starch (6% 130/0.4)|DRUG: Hyperbaric bupivacaine|DRUG: Morphine|DRUG: Isotonic 0.9 sodium chloride (NaCl) solution|DRUG: Ephedrine|DRUG: Atropine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Pain Relief Between High Thoracic Erector Spinae Plane Block and Cervical Epidural Injection
Status: RECRUITING
Conditions: Pain, Chronic
Interventions: PROCEDURE: Erector spinae plane block|PROCEDURE: cervical epidural injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ThermoBreast - Non-contact Breast Cancer Imaging Using AI-enhanced Thermography.
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DIAGNOSTIC_TEST: ThermoBreast - AI-based evaluation of dynamic breast thermography imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Regulation of Optic Nerve Head Blood Flow During Combined Changes in Intraocular Pressure and Arterial Blood Pressure
Status: WITHDRAWN
Conditions: Healthy
Interventions: PROCEDURE: Suction cup application|PROCEDURE: Squatting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Levofloxacin for Acute Ischemic Stroke
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Levofloxacin|DRUG: Levofloxacin simulant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Contrast ICE for Myocardial Scar in VT Ablations
Status: COMPLETED
Conditions: Ventricular Tachycardia|Ischemic Cardiomyopathy
Interventions: DRUG: Perflutren Lipid Microsphere Intravenous Suspension [DEFINITY]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CBT Program for Pain Management for Children and Youth With CP (CBT=Cognitive Behavioral Therapy; CP= Cerebral Palsy)
Status: UNKNOWN
Conditions: Cerebral Palsy|Chronic Pain
Interventions: BEHAVIORAL: Immediate intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does a Nutritional Supplement Increase Vitality, Energy and Perceived Well Being?
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: All Greens|OTHER: Control Formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Long-term Interventional Follow-up Study of Children With Prader-Willi Syndrome Included in the OTBB3 Clinical Trial
Status: RECRUITING
Conditions: Prader-Willi Syndrome
Interventions: DRUG: Follow-up study of the treated cohort|OTHER: Follow-up study of the untreated cohort
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Milnacipran on Fatigue and Quality of Life in Lupus Patients
Status: WITHDRAWN
Conditions: Systemic Lupus Erythematosus|Widespread Pain|Fibromyalgia
Interventions: DRUG: Milnacipran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cannabinoids for Behavioral Problems in Children With ASD
Status: COMPLETED
Conditions: Autistic Disorder
Interventions: DRUG: Cannabinoids - 99% pure cannabinoids mix|DRUG: Placebo|DRUG: Cannabinoids - whole plant extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Anti-CD19 Chimeric Antigen Receptor T Cells (CAR-T Cells) for the Treatment of Relapsed/Refractory CD19+ Malignancies
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Diffuse Large B Cell Lymphoma
Interventions: BIOLOGICAL: Anti-CD19 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biologic Versus Synthetic Mesh for Treatment of Paraesophageal Hernia
Status: UNKNOWN
Conditions: Hiatal Hernia
Interventions: DEVICE: Parietex™ Composite Hiatal Mesh, North Haven, CT|DEVICE: Biodesign™ Surgisis® Graft, Cook Medical, Bloomington
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Study to Investigate the Long-term Safety of FAB122 in Patients With Amyotrophic Lateral Sclerosis
Status: TERMINATED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: FAB122
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Microbiological Aspects of Probiotics in Non-surgical Periodontal Therapy.
Status: NOT_YET_RECRUITING
Conditions: Periodontitis|Probiotics|Non Surgical Periodontal Therapy
Interventions: OTHER: Experimental|OTHER: Negative control|OTHER: Positive control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Analgesic Efficiency of the Transcutaneous Neurostimulation in the Charcot Syndrome Marie Tooth on the Pains of Lower Limbs
Status: UNKNOWN
Conditions: CHARCOT MARIE TOOTH DISEASE
Interventions: DEVICE: TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT
Status: RECRUITING
Conditions: Orthopedic Disorder|Anterior Cruciate Ligament Injuries
Interventions: PROCEDURE: Quad tendon|PROCEDURE: BTB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hydralazine and Valproate Plus Cisplatin Chemoradiation in Cervical Cancer
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: DRUG: Hydralazine and magnesium valproate|PROCEDURE: Punch biopsy of the primary tumor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Octreotide in Patients With GI Bleeding Due to Rendu-Osler-Weber
Status: UNKNOWN
Conditions: Hereditary Hemorrhagic Telangiectasia|Gastrointestinal Hemorrhage|Anemia
Interventions: DRUG: Octreotide LAR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial With Catheter Locking TauroSept® (Taurolidine 2%) or Saline Solution 0,9%
Status: COMPLETED
Conditions: Catheter Related Blood Stream Infections
Interventions: DEVICE: TauroSept®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the "ActiveWaiting App" Encouraging Active Exercise-related Use of Waiting Time
Status: COMPLETED
Conditions: Physical Inactivity
Interventions: DEVICE: ActiveWaiting App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Non-penetrating Deep Sclerectomy Versus Trabeculotomy- Trabeculectomy Operation in Treatment of Primary Congenital Glaucoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Congenital Glaucoma
Interventions: PROCEDURE: non-penetrating deep sclerectomy|PROCEDURE: primary combined trabeculotomy-trabeculectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerability, Safety and Activity of a Muscle Relaxant Molecule IDN5243 in Patients With Low Back Pain
Status: WITHDRAWN
Conditions: Low Back Pain
Interventions: DRUG: 3-glycosyl-3-Odemethylthiocolchicine derivative
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Combination POM, BTZ, Low-Dose DEX, and DARA (PVD-DARA) in Patients With RRMM
Status: WITHDRAWN
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: DRUG: Daratumumab|DRUG: Pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of the Watch Your Weight During Holidays Program for the Prevention of Body Weight Gain in Mexican Adults.
Status: RECRUITING
Conditions: Obesity|Weight Gain|Overweight
Interventions: BEHAVIORAL: Watch your Weight During Holidays|OTHER: Control Group (minimal intervention)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Personalized Antisense Oligonucleotide Therapy for A Single Participant With CHCHD10 ALS
Status: ACTIVE_NOT_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: nL-CHCHD-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computed Tomography (CT) Scans Using CT-On-Rails™ to Pinpoint the Location of the Tumor in Treating Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: computed tomography|PROCEDURE: ultrasound imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: LTX-315 in Patients With Transdermally Accessible Tumours as Monotherapy or Combination With Ipilimumab or Pembrolizumab
Status: COMPLETED
Conditions: Cancer|Melanoma|Breast Cancer|Head and Neck Cancer|Lymphoma|Triple-Negative Breast Cancer
Interventions: DRUG: LTX-315 consecutive lesions|DRUG: LTX-315|DRUG: LTX-315 + ipilimumab|DRUG: LTX-315 + pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare Preperitoneal Analgesia to Epidural Analgesia for Pain Control After Colon and Rectal Surgery
Status: UNKNOWN
Conditions: Colon Cancer|Rectal Cancer|Colonic Diverticulosis
Interventions: DEVICE: Continuous Preperitoneal Analgesia|DEVICE: Continuous Epidural Analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Population Pharmacokinetics and Dosage Individualization of Antibiotics in Elderly Patients
Status: UNKNOWN
Conditions: Elderly Infection
Interventions: DRUG: biapenem,meropenem,piperacillin and tazobactam,tigecycline,levofloxacin.etc
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Botox for the Treatment of Overactive Bladder Secondary to Benign Prostatic Obstruction
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: Botox|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endovascular Embolization of Chronic Subdural Hematomas After Surgery
Status: UNKNOWN
Conditions: Chronic Subdural Hematoma
Interventions: PROCEDURE: Post surgical embolization of middle meningeal artery with liquid embolic agents (ethylene vinyl alcohol copolymers as Onix, Squid, Phil or Libro)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study in Elderly Patients With Chronic Obstructive Bronchitis (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium inhalation capsules for oral inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraperitoneal Infusion of Autologous Monocytes With Sylatron (Peginterferon Alfa-2b) and Actimmune (Interferon Gamma-1b) in Women With Recurrent or Refractory Ovarian Cancer, Fallopian Tube Cancer or Primary Peritoneal Cancer
Status: TERMINATED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cancer
Interventions: BIOLOGICAL: Autologous Monocytes + ACTIMMUNE + SYLATRON
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Immune Response of Novartis Meningococcal ACWY Vaccine In Infants
Status: COMPLETED
Conditions: Meningitis, Meningococcal
Interventions: BIOLOGICAL: Meningococcal ACWY Conjugate Vaccine|BIOLOGICAL: DTaP-IPV-HBV|BIOLOGICAL: Hib|BIOLOGICAL: Rotavirus|BIOLOGICAL: Pneumococcal 7-valent Conjugate Vaccine|BIOLOGICAL: HAV|BIOLOGICAL: MMR-V|BIOLOGICAL: DTaP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate Switching From a Regimen Consisting of Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate (EFV/FTC/TDF) Fixed Dose Combination (FDC) to Emtricitabine/Rilpivirine/Tenofovir Alafenamide (FTC/RPV/TAF) FDC in Virologically-Suppressed, HIV-1 Infected Adults
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: FTC/RPV/TAF|DRUG: EFV/FTC/TDF Placebo|DRUG: EFV/FTC/TDF|DRUG: FTC/RPV/TAF Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bendamustine, Wkly Bortezomib, Lenalidomide and Dexamethasone for Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: iRECIST Evaluation's Relevance for DCR in MMR/MSI Metastatic Colorectal Cancer Patients on Nivolumab and Ipilimumab
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Cancer Colorectal
Interventions: DRUG: Ipilimumab 200 MG in 40 ML Injection|DRUG: Nivolumab 10 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin B6, B12, Folic Acid and Exercise in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: DIETARY_SUPPLEMENT: PD vitamin supplementation|OTHER: PD exercise intervention|OTHER: PD vitamin + exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-Snoring Appliances and Airway Manipulation in Patients Undergoing Anesthetic Sedation
Status: COMPLETED
Conditions: Airway Obstruction|Snoring|Sedation Complication
Interventions: DEVICE: Anti-snoring device|PROCEDURE: No anti -snoring device during their procedure.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pathogenesis of Stress-Induced Cardiomyopathy by I-123 MIBG
Status: COMPLETED
Conditions: Stress Induced Cardiomyopathy
Interventions: DRUG: I-123 radiolabeled metaiodobenzylguanidine cardiac imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Antidepressant Augmentation With Amantadine vs Pramipexole vs Quetiapine in Treatment Resistant Depression
Status: RECRUITING
Conditions: Treatment Resistant Depression
Interventions: DRUG: Quetiapine|DRUG: Amantadine|DRUG: Pramipexole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Restoration of Endodontically Treated Teeth Using Indirect Full Coverage Restorations Compared to Direct Composite Resin Restorations
Status: ACTIVE_NOT_RECRUITING
Conditions: Endodontically Treated Teeth
Interventions: PROCEDURE: Direct composite resin restoration|PROCEDURE: Direct composite resin restoration followed by full coverage metal ceramic crown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-Compassionate Writing for Caregivers of Older Adults
Status: COMPLETED
Conditions: Self-Compassion|Control
Interventions: BEHAVIORAL: Self-Compassionate Writing for Caregivers of Older Adults
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Salvage Chemotherapy of Vinorelbine Plus Oxaliplatin in Metastatic Triple-negative Breast Cancer:a Prospective Trial
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: vinorelbine plus oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Xeloda (Capecitabine) in Patients With Advanced and/or Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Irinotecan|DRUG: capecitabine [Xeloda]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Assessing the Effect of Preoperative Furosemide on Intraoperative Blood Pressure
Status: COMPLETED
Conditions: Hypertension|Hypotension|Edema|Congestive Heart Failure
Interventions: DRUG: furosemide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Maternal Choline Supplementation and Offspring Cognition in Adolescence
Status: ENROLLING_BY_INVITATION
Conditions: Cognitive Deficit in Attention|Executive Dysfunction|Emotional Regulation
Interventions: DIETARY_SUPPLEMENT: Maternal Choline Supplementation 930 mg/d|DIETARY_SUPPLEMENT: Maternal Choline Supplementation 480 mg/d
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Hypofractionation With Simultaneous Integrated Boost for Early Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer After Breast Conserving Surgery Indicating Postoperative Radiotherapy With Boost
Interventions: RADIATION: Hypofractionation with simultaneous integrated boost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short-term Starvation vs. Normal Diet Before Chemotherapy of Solid Tumors
Status: UNKNOWN
Conditions: Cholangiocarcinoma|Pancreatic Ductal Adenocarcinoma|Colorectal Cancer|Gastric Cancer|Adenocarcinoma of the Esophagogastreal Junction|Esophagus Cancer
Interventions: PROCEDURE: Starvation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ibrutinib Combined With Rituximab for Treatment of Relapsed Refractory MYD88 and CD79A/B (or CD79B Alone) DLBCL Who Have Received at Least Two Prior Therapies
Status: NOT_YET_RECRUITING
Conditions: DLBCL|MYD88 Gene Mutation|CD79A Gene Mutation|CD79B Gene Mutation|Relapse|Refractory Lymphoma
Interventions: DRUG: Ibrutinib Combined With Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sunitinib in Treating Patients With Idiopathic Myelofibrosis
Status: TERMINATED
Conditions: Accelerated Phase Chronic Myelogenous Leukemia|Acute Undifferentiated Leukemia|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative|Blastic Phase Chronic Myelogenous Leukemia|Chronic Myelomonocytic Leukemia|Chronic Phase Chronic Myelogenous Leukemia|Mast Cell Leukemia|Meningeal Chronic Myelogenous Leukemia|Primary Myelofibrosis|Progressive Hairy Cell Leukemia, Initial Treatment|Prolymphocytic Leukemia|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Relapsing Chronic Myelogenous Leukemia|Secondary Acute Myeloid Leukemia|Stage I Chronic Lymphocytic Leukemia|Stage II Chronic Lymphocytic Leukemia|Stage III Chronic Lymphocytic Leukemia|Stage IV Chronic Lymphocytic Leukemia|T-cell Large Granular Lymphocyte Leukemia|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Adult Acute Myeloid Leukemia|Untreated Hairy Cell Leukemia
Interventions: DRUG: sunitinib malate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Leg Heat Therapy in Heart Failure With Preserved Ejection Fraction
Status: RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: DEVICE: Leg heat therapy|DEVICE: Leg sham therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of V0057 Versus a Reference Formulation After Single Administration in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: V0057 - A mg|DRUG: Isotretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study Comparing 10 Mg Amlodipine Besylate Orally Disintegrating Tablet (ODT) And 10 Mg Amlodipine Besylate Tablets
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Amlodipine - reference|DRUG: Amlodipine ODT - test|DRUG: Amlodipine ODT - test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of a Rumination Intervention for Individuals With PTSD: A Case Series
Status: ACTIVE_NOT_RECRUITING
Conditions: Posttraumatic Stress Disorder|Rumination - Thoughts
Interventions: OTHER: Rumination Intervention for individuals with PTSD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EEG Characteristics in ECT
Status: COMPLETED
Conditions: Electroconvulsive Therapy|Direct Current Electroencephalogram|Ketamine|Spreadind Depression
Interventions: DRUG: Ketamine|DRUG: Methohexital
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Aerobic and Resistance Training on Exercise Capacity, Depression and Quality of Life in Hypothyroidism.
Status: RECRUITING
Conditions: Comparison of Aerobic Exercise and Resistance Training
Interventions: OTHER: aerobic exercises|OTHER: resistance training|DRUG: medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Progressive Muscle Relaxation Exercise on Care Burden, Depression, Anxiety, and Stress Levels in Dementia Caregivers
Status: COMPLETED
Conditions: Caregiver Burden|Dementia
Interventions: OTHER: Progressive muscle relaxation exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Suubi4Her: Combination Intervention for Adolescent Girls Transitioning Into Adulthood in Uganda
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: BEHAVIORAL: Youth Development Accounts (YDA)|BEHAVIORAL: YDA + Multiple Family Groups (MFG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: REPI : a Randomized Open Label Trial Evaluating the Use of APC in Pre-Implantation Reconstruction of Maxilla
Status: TERMINATED
Conditions: Jaw, Edentulous|Tooth Loss|Maxillary Diseases
Interventions: PROCEDURE: cellular therapy : Autologous platelet concentrate (APC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Effort at Different Expiratory Cycling and Airway Resistance During Pressure Support Ventilation (CYCLOPES)
Status: RECRUITING
Conditions: Respiratory Failure
Interventions: OTHER: Expiratory cycling change at different levels of pressure support ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study Assessing KB707 for the Treatment of Advanced Solid Tumor Malignancies Affecting the Lungs
Status: RECRUITING
Conditions: Lung Cancer, Non-small Cell|Lung Cancer Metastatic|Solid Tumor, Adult|Advanced Cancer|Lung Cancer, Small Cell|Metastatic Colorectal Cancer|Metastatic Renal Cell Carcinoma|Metastatic Hepatocellular Carcinoma|Metastatic Sarcoma|Metastatic Osteosarcoma
Interventions: BIOLOGICAL: KB707
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of INC280 and Buparlisib (BKM120) in Patients With Recurrent Glioblastoma
Status: TERMINATED
Conditions: c-MET Inhibitor; PI3K Inhibitor, PTEN Mutations, Homozygous Del. of PTEN or PTEN Neg. by IHC, c-Met Ampli. by FISH, INC280, BKM120, Buparlisib; Recurrent GBM
Interventions: DRUG: INC280|DRUG: Buparlisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: JTX-2011 Alone and in Combination With Anti-PD-1 or Anti-CTLA-4 in Subjects With Advanced and/or Refractory Solid Tumors
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: JTX-2011|DRUG: Nivolumab|DRUG: Ipilimumab|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Video Assisted Thoracoscopic Surgery (VATS) - Surgical Pleurodesis vs Tube Drainage in Management of Malignant Pleural Effusion (MPE)
Status: RECRUITING
Conditions: Malignant Pleural Effusion|Thoracic Cancer
Interventions: PROCEDURE: VATS-Surgical pleurodesis|PROCEDURE: Tube Drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Combined HAPA and mHealth Intervention to Increase Non-Sedentary Behaviours in Office-Working Adults
Status: COMPLETED
Conditions: Sedentary Lifestyle|Health Behaviour Change
Interventions: BEHAVIORAL: (SB-related planning + daily text messages)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Del Nido Versus Cold Blood Cardioplegia in Aortic Valve Replacement
Status: COMPLETED
Conditions: Aortic Valve Disease|Ischemia-reperfusion Injury
Interventions: DRUG: del Nido cardioplegia|DRUG: cold blood cardioplegia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Gaze Modification Strategies for Toddlers With Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: OTHER: Gaze-contingent eye-tracking technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Oxygen Versus Medical Air for Treatment of CSA in Prader Will Syndrome
Status: RECRUITING
Conditions: Sleep Apnea, Central|Prader-Willi Syndrome
Interventions: BIOLOGICAL: Medical Air vs Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Comfort During High Flow Nasal Cannula Versus Nasal Continuous Airway Pressure (CPAP)
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Newborn|Medical Device Discomfort
Interventions: DEVICE: Respiratory support HFNC|DEVICE: Respiratory support NCPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sargramostim (GM-CSF) + PD-1
Status: WITHDRAWN
Conditions: Unresectable Melanoma|Metastatic Melanoma|Stage III Melanoma|Stage IV Melanoma
Interventions: DRUG: Sargramostim (GM-CSF)|DRUG: Pembrolizumab (anti-PD-1)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Immunogenicity of Dasiglucagon and GlucaGen in Patients With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Hypoglycemia|Diabetes Mellitus, Type 1
Interventions: DRUG: dasiglucagon|DRUG: GlucaGen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of BFR Training Combined With Eccentric Exercise as Assessed by SWE in Subjects With Chronic AT
Status: TERMINATED
Conditions: Achilles Tendinopathy
Interventions: OTHER: Blood Flow Restriction Training|OTHER: Sham Blood Flow Restriction Training|OTHER: Eccentric Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating the Concentration in the Blood of NN1250 in Children, Adolescents and Adults With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin degludec|DRUG: insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous Botulinum Toxin for Cutaneous Allodynia - Enriched Responder Trial
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: Botulinum Toxin Type A|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The TAKO-TSUBO And Cancer Registry
Status: UNKNOWN
Conditions: Tako-Tsubo Cardiomyopathy|Stress-induced Cardiomyopathy|Acute Coronary Syndrome
Interventions: OTHER: Registry of patients with Tako-Tsubo cardiomyopathy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of EDP-297 in Healthy Subjects
Status: COMPLETED
Conditions: NASH - Nonalcoholic Steatohepatitis With Liver Fibrosis
Interventions: DRUG: EDP-297|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis (UC)
Interventions: DRUG: Placebo|DRUG: Upadacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vortioxetine in Patients With Major Depressive Disorder and Coronary Artery Disease
Status: WITHDRAWN
Conditions: Major Depressive Disorder|Coronary Artery Disease
Interventions: DRUG: Vortioxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of mRNA-based Influenza and SARS-CoV-2 (COVID-19) Multi-component Vaccines in Healthy Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: SARS-CoV-2|Influenza
Interventions: BIOLOGICAL: Influenza Vaccine 1|BIOLOGICAL: mRNA-1083.1|BIOLOGICAL: mRNA-1083.2|BIOLOGICAL: mRNA-1083.3|BIOLOGICAL: Investigational Influenza Vaccine 1|BIOLOGICAL: Investigational COVID-19 Vaccine 1|BIOLOGICAL: COVID-19 Vaccine 1|BIOLOGICAL: Investigational Influenza Vaccine 2|BIOLOGICAL: Influenza Vaccine 2|BIOLOGICAL: mRNA-1083|BIOLOGICAL: Investigational COVID-19 Vaccine 2|BIOLOGICAL: COVID-19 Vaccine 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sun Yat-Sen Cohort of CNS Idiopathic Inflammatory Demyelinating Diseases
Status: RECRUITING
Conditions: Multiple Sclerosis, MS|Neuromyelitis Optica Spectrum Disorders|Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease|Acute Disseminated Encephalomyelitis|Clinically Isolated Syndrome|Demyelinating Disorder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pharmacokinetic Study of Narlaprevir as a Single Dose or With Ritonavir Combination in Patients With Hepatic Impairment and Healthy Matched Volunteers
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: Narlaprevir|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Treatment of Severe Acute Respiratory Syndrome With Veru-111
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Adult
Interventions: DRUG: Veru-111
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VAT-2: Evaluation of a Virtual Antimicrobial Stewardship Team (VAT) on Antibiotic Prescriptions in Nursing Homes
Status: RECRUITING
Conditions: Bacterial Infections
Interventions: OTHER: Virtual Antimicrobial stewardship Team (VAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Late Dislocation of Intraocular Lens (IOL) Following Cataract Surgery: an Evaluation of Two Different Surgical Methods
Status: UNKNOWN
Conditions: Intraocular Lens Dislocation
Interventions: PROCEDURE: Intraocular lens repositioning by scleral suturing|PROCEDURE: Intraocular lens exchange with retropupillary iris-claw lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Vancomycin for Neurosurgery Wound Prophylaxis
Status: UNKNOWN
Conditions: Infection|Surgery|Nervous System Diseases
Interventions: DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Preventing Mother-to-child Transmission of Hepatitis B Virus With Tenofovir Alafenamide (TAF)
Status: UNKNOWN
Conditions: Hepatitis B, Chronic|Mother to Child Transmission
Interventions: DRUG: antiviral prophylaxis with Tenofovir Alafenamide Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A First-in-human, Single Ascending Dose Study of GZ402668 in Patients With Progressive Multiple Sclerosis
Status: COMPLETED
Conditions: Progressive Multiple Sclerosis
Interventions: DRUG: GZ402668|DRUG: placebo|DRUG: GZ402668|DRUG: placebo|DRUG: acyclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neurobiology of Nicotine and Non-nicotine Components of Tobacco Addiction
Status: COMPLETED
Conditions: Smoking
Interventions: BEHAVIORAL: Quit smoking|DRUG: Nicotine patch|DRUG: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Early transfusIon of Convalescent Plasma in Elderly COVID-19 Patients. to Prevent Disease Progression.
Status: COMPLETED
Conditions: Coronavirus Disease 2019 )COVID-19)
Interventions: BIOLOGICAL: COVID-19 Convalescent Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Preventing Tolerance to Oxymetazoline in Allergic Rhinitis
Status: WITHDRAWN
Conditions: Allergic Rhinitis|Tachyphylaxis|Rhinitis Medicamentosa
Interventions: DRUG: oxymetazoline-fluticasone propionate|DRUG: Oxymetazoline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Oryz-Aspergillus Enzyme and Pancreatin Tablet in Patients With Cirrhosis and Malnutrition
Status: UNKNOWN
Conditions: Cirrhosis
Interventions: DRUG: Oryz-Aspergillus Enzyme and Pancreatin Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Melatonin in Pediatric Hemodialysis Patients
Status: RECRUITING
Conditions: Hemodialysis Complication|Oxidative Stress|Inflammation
Interventions: DIETARY_SUPPLEMENT: Melatonin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Mirikizumab (LY3074828) in Participants With Active Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: Mirikizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment 1 - 1
Status: WITHDRAWN
Conditions: Heroin Dependence|Opioid-Related Disorders
Interventions: DRUG: Heroin Dependence
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Femoral Peri-arterial Local Anesthetic Injection Decreases Tourniquet Associated Ischemic Hypertension
Status: COMPLETED
Conditions: Tourniquet Hypertension|Intraoperative Hypertension|Total Ankle Arthroplasty|Ankle Fusion
Interventions: DRUG: Mepivacaine|PROCEDURE: Perifemoral Injection of Local Anesthetic|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluating the Impact of Body Image Edutainment on Adolescent Girls' Body Image
Status: COMPLETED
Conditions: Body Image|Eating Disorder Symptom
Interventions: BEHAVIORAL: Girl's room video|OTHER: Control video - Chicken Girls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: HeartPhone Cancer Survivors Trial 2019
Status: TERMINATED
Conditions: Breast Cancer|Leukemia|Lymphoma
Interventions: BEHAVIORAL: HeartPhone app|DRUG: Acetylcholine|DRUG: Sodium Nitroprusside|DRUG: L-Arginine, N2-((4-Methylphenyl)Sulfonyl)-, Methyl Ester
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Different Materials Used in Orogastric Tube Removal on Skin Condition in Premature Babies
Status: ACTIVE_NOT_RECRUITING
Conditions: Neonatal Skin Conditions
Interventions: OTHER: Sunflower oil|OTHER: Slicone based spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gemcitabine, Herceptin and Radiation to Treat Cancer of the Pancreas
Status: COMPLETED
Conditions: Pancreatic Cancer|Pancreatic Neoplasm
Interventions: DRUG: Gemcitabine|DRUG: Herceptin|PROCEDURE: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Accelerated Rule Out of Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: PROCEDURE: Accelerated, combined biomarker rule-out strategy for MI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Efficacy of Stereotactic Radiotherapy and Microwave Ablation for Liver Metastases From Colorectal Cancer.
Status: UNKNOWN
Conditions: Radiotherapy|Microwave Ablation|Liver Metastases|Colorectal Cancer
Interventions: RADIATION: stereotactic radiotherapy|OTHER: microwave alabation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT