pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Vaccine Therapy and Resiquimod in Treating Patients With Stage II, Stage III, or Stage IV Melanoma That Has Been Completely Removed by Surgery
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: DRUG: resiquimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Effect of Ginkgo Biloba Extract on Optic Nerve Head Perfusion Examined Using OCTA
Status: COMPLETED
Conditions: Glaucoma
Interventions: DIETARY_SUPPLEMENT: Ginkgo biloba extract
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retreatment of Dialysis Patients With Chronic Hepatitis C With Pegylated Interferon Alfa-2a Plus Low Dose Ribavirin
Status: COMPLETED
Conditions: Chronic Hepatitis C|Hemodialysis
Interventions: DRUG: Pegylated interferon alfa-2a and ribavirin|DRUG: Pegylated interferon alfa-2a and ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability and Immunogenicity of Three Doses of GBS Vaccine in Elderly Participants
Status: COMPLETED
Conditions: Group B Streptococcal Infections
Interventions: BIOLOGICAL: GBS-NN/NN2|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: New Method for Distal Interlocking of Cannulated Intramedullary Nails
Status: TERMINATED
Conditions: Fracture
Interventions: DEVICE: The Guiding Star|DEVICE: fluoroscopy (OEC 9800 - General Electric)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence Study of Famitinib Malate in Healthy Volunteers Under Fasting Condition
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: famitinib malate T(5 mg*4)、famitinib malate R(20 mg)|DRUG: famitinib malate T(5 mg*4)、famitinib malate R(20 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation Of Nonsurgical Treatment Of Deep Periodontal Pockets (7-10mm) Using AIRFLOW® Prophylaxis Master Device With Erythritol Powder vs Conventional Instrumentation
Status: RECRUITING
Conditions: Periodontal Pocket|Periodontitis|Gingival Diseases|Gingival Bleeding
Interventions: PROCEDURE: Hand and ultrasonic scalers and curettes|DEVICE: Electro Medical Systems AIRFLOW® Prophylaxis Master Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Utility of IVCM to Assess Cellular Response and Efficacy of Long-term Topical Steroid Treatment in Patients With DED
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: Lotemax|DRUG: Soothe Tired Eyes Lubricant Eye Drop (Artificial Tears)|DIAGNOSTIC_TEST: In Vivo Confocal Microscopy (IVCM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Physical Rehabilitation Among Patients Undergoing Radical Cystectomy Due to Urinary Bladder Cancer
Status: COMPLETED
Conditions: Urinary Bladder Cancer
Interventions: OTHER: The CanMoRe programme|OTHER: Home exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Baclofen and Hypoxia-induced Periodic Ventilation
Status: COMPLETED
Conditions: CHEYNE Stokes Respiration
Interventions: DRUG: Baclofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Flaps in Surgical Removal of Impacted Lower Third Molar
Status: UNKNOWN
Conditions: Impacted Third Molar Tooth
Interventions: PROCEDURE: Surgical Extraction of lower third molar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Steroid vs. Anti-vascular Endothelial Growth Factor for Diabetic Macular Edema Prior to Phacoemulsification
Status: UNKNOWN
Conditions: Diabetic Macular Edema|Cataract
Interventions: DRUG: Bevacizumab|DRUG: Ranibizumab|DRUG: Aflibercept|DRUG: Ozurdex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Fluor Protector S in the Prevention in Adolescents
Status: UNKNOWN
Conditions: Dental Caries|Fluor
Interventions: DEVICE: Fluor Protector S|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective Study on Esophagogastrostomy by an Innovative Surgical Technique
Status: RECRUITING
Conditions: Gastric Cancer|Adenocarcinoma of Esophagogastric Junction
Interventions: PROCEDURE: Performing totally laparoscopic proximal gastrectomy with esophagogastrostomy by fissure technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of High-flow Oxygen vs. BiPAP in Type II (Hypercapnic) Respiratory Failure
Status: COMPLETED
Conditions: Respiratory Failure|Respiratory Insufficiency|Respiratory Tract Diseases|COPD|COPD Exacerbation|Pneumonia|Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Non-Invasive Ventilation|DEVICE: High-Flow Nasal Cannula
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics of Bolus Versus Continuous Cefazolin Infusion in Patients Undergoing Major Surgery
Status: COMPLETED
Conditions: Plasma Concentration of Antibiotics
Interventions: DRUG: BOLUS INFUSION (Ancef)|DRUG: CONTINUOUS INFUSION (Ancef)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of YYD302 (Phase3) for Treatment of Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: YYD302 2ml|DRUG: Active comparator: Synovian Inj.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Peginterferon Alpha-2b and Thalidomide in Adults With Recurrent Gliomas
Status: COMPLETED
Conditions: Glioma
Interventions: BIOLOGICAL: PEG-interferon alfa-2b|DRUG: Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3T Therapy in the Treatment of MDA5-positive Dermatomyositis
Status: ENROLLING_BY_INVITATION
Conditions: Dermatomyositis
Interventions: DRUG: Tofacitinib 5 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Immunity and Safety Following Vaccination With the JEV IC51 (IXIARO®, JESPECT®) in Pediatric Population In Non Endemic Countries. Uncontrolled, Ph3 FU-Study
Status: COMPLETED
Conditions: Japanese Encephalitis
Interventions: PROCEDURE: Blood draw|BIOLOGICAL: IC51 has given in the parent study IC51-322
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Safety, Tolerability, and Antiviral Activity of ACH-0143102 Plus Ribavirin In Treatment-naive Hepatitis C Virus Infection Genotype 1b Participants
Status: COMPLETED
Conditions: Chronic Hepatitis C Infection
Interventions: DRUG: ACH-0143102|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Massage to Manage Withdrawal Related Anxiety
Status: COMPLETED
Conditions: Substance Withdrawal Syndrome|Drug Withdrawal Symptoms|Anxiety
Interventions: PROCEDURE: Therapeutic Massage|PROCEDURE: Relaxation Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyaluronic Acid in Patients With Gastroesophageal Reflux Disease
Status: RECRUITING
Conditions: Gastroesophageal Reflux
Interventions: PROCEDURE: Hyaluronic acid injection|PROCEDURE: Sodium chloride injection (control group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety, Tolerability and Pharmacokinetics of GLPG2737 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG2737 single dose|DRUG: Placebo single dose|DRUG: GLPG2737 multiple dose|DRUG: GLPG2737 multiple dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Endodrill vs. Conventional Biopsy. Diagnostics and Genetic Analysis
Status: TERMINATED
Conditions: Esophageal Neoplasm
Interventions: DEVICE: Endodrill Biopsy|DEVICE: Conventional Biopsy forceps
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Genomic Medicine for Ill Neonates and Infants (The GEMINI Study)
Status: COMPLETED
Conditions: Pediatric: Genetic Syndrome
Interventions: DIAGNOSTIC_TEST: rapid whole genomic sequencing (rWGS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Fostamatinib as a Single Agent or in Combination With Ruxolitinib for Treatment of Patients With Myelofibrosis With Severe Thrombocytopenia
Status: TERMINATED
Conditions: Myelofibrosis|Thrombocytopenia
Interventions: DRUG: Fostamatinib|DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of AD113 and Atomoxetine in OSA Patients With Hypertension
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Hypertension
Interventions: DRUG: AD113|DRUG: Atomoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Investigating the Renal Tolerability, Efficacy, and Safety of a CNI-free Versus a Standard Regimen in de Novo Heart Transplant (HTx) Recipients
Status: COMPLETED
Conditions: Heart Transplantation
Interventions: DRUG: Everolimus (EVR)|DRUG: cyclosporine A (CyA)|DRUG: tacrolimus (TAC)|DRUG: Enteric coated mycophenolate sodium (EC-MPS)|DRUG: mycophenolate mofetil (MMF)|DRUG: Corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Liraglutide for Weight Management in Pubertal Adolescent Subjects With Obesity
Status: COMPLETED
Conditions: Metabolism and Nutrition Disorder|Obesity
Interventions: DRUG: Liraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Ultrasound Guided Transversus Abdominis Plane Block in Pain Control After Hepatectomy
Status: NOT_YET_RECRUITING
Conditions: Analgesia
Interventions: PROCEDURE: ultrasound guided subcostal TAP block|PROCEDURE: ultrasound guided combined posterior and subcostal TAP block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of 80-mg Atorvastatin on Myocardial Edema
Status: COMPLETED
Conditions: Myocardial Edema
Interventions: DRUG: Atorvastatin 80mg|DRUG: Atorvastatin 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multi-center Trial of Percutaneous Pulmonary Valve Implantation With Venus-p
Status: UNKNOWN
Conditions: Pulmonary Regurgitation|Tetralogy of Fallot
Interventions: DEVICE: Venues-P Valve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Topical Silver Colloid in Treating Patients With Recalcitrant Chronic Rhinosinusitis
Status: COMPLETED
Conditions: Rhinosinusitis
Interventions: DRUG: Silver Colloid|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Natural History and Biology of Long-Term Late Effects Following Hematopoietic Cell Transplant for Childhood Hematologic Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia/Lymphoma|Myelodysplasia|Acute Myelogenous Leukemia|Juvenile Myelomonocytic Leukemia|Chronic Myelogenous Leukemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Computed Tomography (CT) Based Lymphatic Mapping and Localization of Sentinel Lymph Node in Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DEVICE: Breast Lesion Localization Needles (interv)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Oral Care Program for Residients in Long-term Care Facility
Status: NOT_YET_RECRUITING
Conditions: Elder|Oral Hygiene
Interventions: BEHAVIORAL: Electric toothbrush|BEHAVIORAL: Soft bristle toothbrush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post Operative Continuous Active Combination Sex Steroids for the Prevention of Recurrent Endometrioma Formation
Status: WITHDRAWN
Conditions: Endometrioma
Interventions: DRUG: Norethindrone acetate and ethinyl estradiol tablets, USP|DRUG: ferrous fumarate (placebo) tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of Redirected Haploidentical Natural Killer Cell Infusions for B-Lineage Acute Lymphoblastic Leukemia
Status: SUSPENDED
Conditions: B-cell Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: anti-CD19 redirected NK cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ciprofloxacin Versus Levofloxacin in Stem Cell Transplant
Status: ACTIVE_NOT_RECRUITING
Conditions: Prophylaxis|Stem Cell Transplant Complications
Interventions: DRUG: Levofloxacin|DRUG: Ciprofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Aripiprazole Lauroxil or Paliperidone Palmitate for the Treatment of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: COMBINATION_PRODUCT: Aripiprazole Lauroxil|DRUG: Paliperidone Palmitate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Response of Individuals With Ataxia-Telangiectasia to Metformin and Pioglitazone
Status: COMPLETED
Conditions: Ataxia-Telangiectasia
Interventions: DRUG: Metformin|DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Contact Lenses With Experimental Dye on Visual Function
Status: COMPLETED
Conditions: Ametropia
Interventions: DEVICE: senofilcon A with new UV blocker|DEVICE: senofilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Macitentan (ACT-064992) on Morbidity and Mortality in Patients With Symptomatic Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: macitentan (ACT-064992)|DRUG: macitentan (ACT-064992)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of TRC105 and Sorafenib in Patients With HCC
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Carotuximab (TRC105)|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnosing Perineal Tears, Does Different Assessment Methods Affect the Midwife's Clinical Judgement of Perineal Tears?
Status: COMPLETED
Conditions: Obstetric Perineal Rupture
Interventions: DEVICE: Objective measurements of perineal tears with "Peri-Rule"|OTHER: Visual and digital assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Trastuzumab Emtansine (Trastuzumab-MCC-DM1, T-DM1) in Combination With Pertuzumab Administered to Patients With Human Epidermal Growth Factor Receptor-2 (HER2)-Positive Locally Advanced or Metastatic Breast Cancer Who Have Previously Received Trastuzumab
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Trastuzumab emtansine [Kadcyla] 3.0 mg/kg|DRUG: Trastuzumab emtansine [Kadcyla] 3.6 mg/kg|DRUG: Pertuzumab 420 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Emotional Freedom Technique on Premenstrual Syndrome and Pain in University Students
Status: COMPLETED
Conditions: Premenstrual Syndrome
Interventions: OTHER: EFT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Remodulin in Adults With Congenital Heart Disease (ACHD) and Pulmonary Hypertension
Status: WITHDRAWN
Conditions: Congenital Heart Disease
Interventions: DRUG: Remodulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Utilization of PTNS During Office-Based Cystoscopy
Status: UNKNOWN
Conditions: Cystoscopy
Interventions: PROCEDURE: Percutaneous Tibial Nerve Stimulation (PTNS)|PROCEDURE: Sham Percutaneous Tibial Nerve Stimulation (PTNS)|PROCEDURE: Standard Cystoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase I Pilot Study of Ad5-CB-CFTR, an Adenovirus Vector Containing the Cystic Fibrosis Transmembrane Conductance Regulator Gene, in Patients With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: GENETIC: Ad5-CB-CFTR
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy (CBT) Study Evaluating the Updating of Persecutory Beliefs
Status: COMPLETED
Conditions: Schizophrenia; Psychosis|Persecutory Delusion
Interventions: BEHAVIORAL: Worry Intervention|BEHAVIORAL: Befriending
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adenosine and Magnesium Sulphate as Adjuvants for PECS Block.
Status: COMPLETED
Conditions: Breast Surgery
Interventions: DRUG: Bupivacaine 0.25%|DRUG: Adenosine 12mg|DRUG: Magnesium Sulphate 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: ELVN-002 in HER2 Mutant Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: HER2 Mutant Non-small Cell Lung Cancer|HER2-positive Metastatic Breast Cancer|HER2 Gene Mutation|HER2 Amplification
Interventions: DRUG: ELVN-002|DRUG: Fam-Trastuzumab Deruxtecan-Nxki|DRUG: Trastuzumab emtansine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability and Food Effect Study for GSK163090 in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Depressive Disorder and Anxiety Disorders
Interventions: DRUG: GSK163090 capsule, fasted|DRUG: GSK163090 Tablet, fasted|DRUG: GSK163090 Tablet, fed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2A Dose-ranging and Pharmacokinetic Study of an Oral Vitamin D Compound (DP001) in Secondary Hyperparathyroidism
Status: COMPLETED
Conditions: Secondary Hyperparathyroidism
Interventions: DRUG: DP001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to JUUL ENDS
Status: COMPLETED
Conditions: Electronic Cigarette Use|Cigarette Use, Electronic|Tobacco Use|Tobacco Smoking
Interventions: OTHER: Switch from UB of Combustible Cigarette to JUUL 5% Virginia Tobacco ENDS|OTHER: Switch from UB of Combustible Cigarette to JUUL 3% Virginia Tobacco ENDS|OTHER: Switch from UB of Combustible Cigarette to JUUL 5% Mint ENDS|OTHER: Switch from UB of Combustible Cigarette to JUUL 3% Mint ENDS|OTHER: Switch from UB of Combustible Cigarette to JUUL 5% Menthol ENDS|OTHER: Switch from UB of Combustible Cigarette to JUUL 3% Menthol ENDS|OTHER: Switch from UB of Combustible Cigarette to JUUL 5% Mango ENDS|OTHER: Switch from UB of Combustible Cigarette to JUUL 3% Mango ENDS|OTHER: Switch to Dual-use of JUUL 5% and UB of Combustible Cigarette|OTHER: Tobacco/Nicotine Abstention|OTHER: Usual Brand of cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Axillary Management in Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy
Status: RECRUITING
Conditions: Breast Cancer|Sentinel Lymph Node|Neoplasm, Breast
Interventions: PROCEDURE: Axillary lymph node dissection|RADIATION: Axillary radiotherapy|RADIATION: Breast or chest wall radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Knowledge Translation Intervention for ACL Injury Prevention Program in Youth Soccer
Status: ACTIVE_NOT_RECRUITING
Conditions: Anterior Cruciate Ligament Injuries|Lower Extremity Problem
Interventions: BEHAVIORAL: Knowledge Translation Intervention|BEHAVIORAL: Educational handout
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Explore the Clinical Application Value of Ciprofol in Painless Colonoscopy
Status: COMPLETED
Conditions: Induction of Anaesthesia
Interventions: DRUG: Propofol|DRUG: Ciprofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficiency of Soft Tissue Diode Laser Application on Healing of Periapical Tissues
Status: COMPLETED
Conditions: Periapical Diseases
Interventions: DEVICE: Soft tissue Diode laser application|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Recovery of Reaching Movement in Breast Cancer Survivors: Two Different Rehabilitative Protocols in Comparison
Status: COMPLETED
Conditions: Breast Cancer|Breast Cancer Lymphedema|Pain|Pain, Postoperative|Pain, Chronic|Mastectomy; Lymphedema|Breast Surgery
Interventions: OTHER: Single rehabilitative treatment|OTHER: Group rehabilitative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 'Acupuncture Therapy' for Pain and Function Recovery in Spine Surgery Patients
Status: COMPLETED
Conditions: Pain|Low Back 'Spine Fusion' Surgery
Interventions: PROCEDURE: Acupuncture therapies|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating of the Effect of Fingolimod With Fish Oil on Relapsing-Remitting Multiple Sclerosis Patients
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Fingolimod|DIETARY_SUPPLEMENT: Fish Oil|DRUG: Placebo (for Fish Oil)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Amniotic Fluid Mesenchymal Stem Cells Developed for Chondrogenic Treatment (AFCC) Injection in Elderly Knee Osteoarthritis Patients
Status: ENROLLING_BY_INVITATION
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: allogenic amniotic fluid mesenchymal stem cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of SGN-40 in Patients With Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin Lymphoma
Interventions: DRUG: SGN-40 (anti-huCD40 mAb)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Exercise, Nutrition Supplement and Frailty of Older Population
Status: COMPLETED
Conditions: Sarcopenia|Physical Exercise|Nutrition Poor|Elderly
Interventions: BEHAVIORAL: individual physical exercise group|DIETARY_SUPPLEMENT: individual Branched-Chain Amino Acids supplements group|OTHER: combination of physical exercise and nutrition supplements group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypertonic Saline Nasal Irrigation and Gargling for the Common Cold.
Status: COMPLETED
Conditions: Common Cold|Upper Respiratory Tract Infections
Interventions: OTHER: Nasal Irrigation & Gargling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Digital Human-Based Brief Interventions for Harmful Alcohol Use: The PAHOLA Project
Status: NOT_YET_RECRUITING
Conditions: Alcohol Drinking|Alcoholism
Interventions: OTHER: PAHOLA (digital health assistant)|OTHER: Standard information on alcohol use and health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketoprofen Gel vs Placebo in Low Back Pain
Status: UNKNOWN
Conditions: Mechanical Low Back Pain
Interventions: DRUG: Ketoprofen|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of a New Flowable and a New Sculptable Universal Bulk-fill Composite for Direct Restorative Treatment
Status: RECRUITING
Conditions: Insufficient Dental Filling or Primary Caries (Class I or II Cavities in Premolars or Molars)
Interventions: DEVICE: TM Fill in combination with TM Flow
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iron Infusion Into a Vein Compared to Iron Tablet Taken by Mouth for Treating Iron Deficiency Anemia in Pregnancy (IVON)
Status: COMPLETED
Conditions: Iron Deficiency Anemia of Pregnancy
Interventions: DRUG: Ferric carboxymaltose|DRUG: Ferrous sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Grass Pollen Allergy Vaccine BM32
Status: COMPLETED
Conditions: Grass Pollen Allergy
Interventions: BIOLOGICAL: BM32|BIOLOGICAL: BM32|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DEfibrillators To REduce Risk by MagnetIc ResoNance Imaging Evaluation
Status: TERMINATED
Conditions: Coronary Artery Disease|Left Ventricular Dysfunction|Sudden Cardiac Death
Interventions: DEVICE: Defibrillator|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melatonin Supplementation for Delirium Prevention in Acutely Hospitalized Elderly
Status: COMPLETED
Conditions: Delirium
Interventions: DIETARY_SUPPLEMENT: melatonin|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ursodeoxycholic Acid in Bariatric Surgery
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease|Morbid Obesity
Interventions: DRUG: Ursodeoxycholic Acid (UDCA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Research Study of Visilizumab for Treatment of Glucocorticoid- Refractory Graft Versus Host Disease
Status: UNKNOWN
Conditions: Graft-vs-Host Disease
Interventions: DRUG: Visilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Orally Administered Strontium L-Lactate in Healthy Adults
Status: COMPLETED
Conditions: Low Bone Density|Osteopenia|Osteoporosis, Postmenopausal
Interventions: DIETARY_SUPPLEMENT: Strontium L-lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Elective Umbilical Hernia Repair in Patients With Cirrhosis
Status: UNKNOWN
Conditions: Cirrhosis, Umbilical Hernia
Interventions: OTHER: Screening|PROCEDURE: Preoperative optimization|PROCEDURE: Umbilical hernia repair
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Preventive Infection Role of One Week Antibiotics Before Minimally Invasive Upper Tract Lithotomy
Status: UNKNOWN
Conditions: Complication of Surgical Procedure
Interventions: DRUG: levofloxacin|DRUG: Nitrofurantoin|DRUG: cefuroxime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessing of Physicians' Knowledge About International Guidelines of Albumin Use in Patients With Liver Cirrhosis
Status: UNKNOWN
Conditions: Liver Cirrhoses
Interventions: BEHAVIORAL: Questionnaire about albumin use in liver cirrhosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Characterization of Cardiovascular Diseases and Risk Factors in Patients With Suspected SARS-CoV2/Covid-19 Infection
Status: COMPLETED
Conditions: Cardiovascular Diseases|Cardiovascular Risk Factor|SARS
Interventions: DIAGNOSTIC_TEST: Assessment of cardiovascular diseases and cardiovascular risk factors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Epidural-inhalational Versus Epidural-intravenous Anaesthesia on Anti-tumor Immunity in Patients With Cancer Colon
Status: COMPLETED
Conditions: Immunity Factors in Cancer Colon Patients
Interventions: PROCEDURE: thoracic epidural
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Effects of Risperidone and Olanzapine on Blood Glucose (Sugar) in Patients With Schizophrenia or Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenia|Diabetes Mellitus
Interventions: DRUG: Olanzapine|DRUG: Risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Development of Radiation Free Whole Body Magnetic Resonance (MR) Imaging Technique for Staging Children With Cancer
Status: RECRUITING
Conditions: Cancer
Interventions: PROCEDURE: WB-DW-MR scan|PROCEDURE: 18-F-FDG PET scan|DRUG: Ferumoxytol|PROCEDURE: 18-F-FDG PET/MR scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: TAP Block With Liposomal Bupivacaine Versus Bupivacaine in Robotic Hysterectomy
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: Bupivacaine|DRUG: liposomal bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of BOTOX® Compared to Topiramate for the Prevention of Chronic Migraine in Adults
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: BIOLOGICAL: onabotulinumtoxinA|DRUG: Topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Inhaled Corticosteroid Plus Montelukast Compared With Inhaled Corticosteroid Therapy Alone in Patients With Chronic Asthma (0476-386)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Comparator: mometasone|DRUG: Comparator: montelukast|DRUG: Comparator: placebo (unspecified)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Oral and Intravenous Palonosetron for the Prevention of Nausea and Vomiting
Status: COMPLETED
Conditions: Chemotherapy-Induced Nausea and Vomiting
Interventions: DRUG: Oral palonosetron|DRUG: I.V. palonosetron|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Spinal Decompression Therapy in Radicular Chronic Low Back Pain
Status: COMPLETED
Conditions: Radiculopathy Lumbar
Interventions: OTHER: Spine decompression with core stability exercises|OTHER: Spine decompression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of Lanreotide Autogel® in Chinese Participants With GEP-NETs
Status: COMPLETED
Conditions: Gastroenteropancreatic Neuroendocrine Tumor
Interventions: DRUG: Lanreotide autogel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomised Study Evaluating Adjuvant Chemotherapy After Resection of Stage III Colonic Adenocarcinoma in Patients of 70 and Over
Status: RECRUITING
Conditions: Colonic Adenocarcinoma
Interventions: DRUG: LV5FU2 or capectitabine|DRUG: FOLFOX4 or XELOX|OTHER: Observation|DRUG: LV5FU2 or capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Multicenter, Collaborative Study to Determine the Prevalence of Nontuberculous Mycobacteria (NTM) in Pediatric Patients With Cystic Fibrosis in Florida
Status: COMPLETED
Conditions: Cystic Fibrosis|Pediatrics
Interventions: BIOLOGICAL: Sputum
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pulsed Oral Sirolimus in Autosomal Dominant Polycystic Kidney Disease
Status: UNKNOWN
Conditions: Polycystic Kidney, Type 1 Autosomal Dominant Disease|Polycystic Kidney, Type 2 Autosomal Dominant Disease
Interventions: DRUG: Sirolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The RESCUE II Study. The Bashir™ Endovascular Catheter (BEC),
Status: NOT_YET_RECRUITING
Conditions: Acute Submassive Pulmonary Embolism
Interventions: DEVICE: The Bashir™ Endovascular Catheter (BEC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Influenza Vaccine Containing Different H3 Antigens in Healthy Adults 18 to 30 Years of Age
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Quadrivalent RIV with H3 strain 1|BIOLOGICAL: Quadrivalent RIV with H3 strain 2|BIOLOGICAL: Quadrivalent RIV with H3 strain 3|BIOLOGICAL: Quadrivalent RIV with H3 strain 4|BIOLOGICAL: Quadrivalent RIV with 2018-2019 NH H3 strain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Optimization of Contrast Agent Dose in CT With Lean Body Weight
Status: COMPLETED
Conditions: Contrast Agent With Lean Body Weight
Interventions: DRUG: Iopamidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vitamin D, HbA1c and Vitamin B12 Levels in Patients
Status: COMPLETED
Conditions: Serum HbA1c and Vitamin D, Vitamin B12 Values in Periodontal Diseases
Interventions: DIAGNOSTIC_TEST: HbA1c, Vitamin D, Vitamin B12
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Siliphos in Adults With Non-alcoholic Steatohepatitis (NASH)
Status: COMPLETED
Conditions: Fatty Liver
Interventions: DRUG: IdB 1016 (Siliphos)|DRUG: Matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Retention of Complete Denture Using Rapid Prototyping
Status: UNKNOWN
Conditions: Retention of 3D Printed Dentures
Interventions: OTHER: 3d printed denture|OTHER: conventional dentures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nebulized Lidocaine and Intranasal Midazolam for NGT Insertion in Children
Status: UNKNOWN
Conditions: Procedural Anxiety|Procedural Pain
Interventions: DRUG: Nebulized Lidocaine|DRUG: Intranasal Midazolam|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Doravirine/Islatravir (DOR/ISL 100 mg/0.75 mg) to Evaluate the Antiretroviral Activity, Safety, and Tolerability in Treatment-Naïve Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-020)
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV-1 Infection
Interventions: DRUG: DOR/ISL|DRUG: BIC/FTC/TAF|DRUG: Placebo to BIC/FTC/TAF|DRUG: Placebo to DOR/ISL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Root Coverage Using ADM and Coronally Positioned Tunnel With or Without Enamel Matrix Derivative
Status: RECRUITING
Conditions: Recession, Gingival
Interventions: BIOLOGICAL: Regenerative tissue matrix and enamel matrix derivative|BIOLOGICAL: Regenerative tissue matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Rapid Maxillary Expansion Facilitated by Micro-osteoperforation in Adolescent Patients With Skeletal Maxillary Constriction
Status: UNKNOWN
Conditions: Posterior Crossbite
Interventions: DEVICE: tooth borne hyrax expander|PROCEDURE: microosteoperforation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peri-treatment of SGLT-2 Inhibitor on Myocardial Infarct Size and Remodeling Index in Patients With Acute Myocardial Infarction and High Risk of Heart Failure Undergoing Percutaneous Coronary Intervention
Status: RECRUITING
Conditions: Acute Myocardial Infarction|Heart Failure
Interventions: DRUG: SGLT2 inhibitor|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Versus Midazolam Added to Ketamine in Pediatric Patients Undergoing Bone Marrow Aspiration and Biopsy
Status: COMPLETED
Conditions: Procedural Sedation and Analgesia During Bone Marrow Aspiration and Biopsy
Interventions: DRUG: midazolam intravenous infusion of 0.05 mg/kg plus 1 mg/kg ketamine|DRUG: Dexmedetomidine intravenous infusion of 2mic/kg plus 1 mg/kg ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Understanding Outcomes With the EMBLEM™ S-ICD in Primary Prevention Patients With Low Ejection Fraction
Status: COMPLETED
Conditions: Ventricular Fibrillation|Ventricular Tachycardia|Low Cardiac Output
Interventions: DEVICE: EMBLEM S-ICD System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 2 Study to Determine the Safety and Efficacy of BIND-014 (Docetaxel Nanoparticles for Injectable Suspension) as Second-line Therapy to Patients With Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: BIND-014
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increasing Academic Success in Middle School Students With ADHD
Status: COMPLETED
Conditions: Behavior Therapy + MI Intervention (Supporting Teens' Academic Needs Daily)|Treatment as Usual
Interventions: BEHAVIORAL: Behavior Therapy + Motivational Interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Different Manual Therapy Approaches in Patients With Chronic Neck Pain
Status: NOT_YET_RECRUITING
Conditions: Neck Pain
Interventions: OTHER: Massage group|OTHER: Connective tissue massage group|OTHER: Mobilization group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of the Safety and Efficacy of E7820 Plus Cetuximab in Colorectal Cancer, Preceded by a Run-in Study in Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Colorectal Cancer
Interventions: DRUG: E7820 plus cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) Monotherapy in Advanced Solid Tumors and Pembrolizumab Combination Therapy in Advanced Non-small Cell Lung Cancer/ Extensive-disease Small Cell Lung Cancer (MK-3475-011/KEYNOTE-011)
Status: COMPLETED
Conditions: Solid Tumor|Non-small Cell Lung Cancer|Small Cell Lung Cancer
Interventions: BIOLOGICAL: Pembrolizumab 2 mg/kg|BIOLOGICAL: Pembrolizumab 10 mg/kg|BIOLOGICAL: Pembrolizumab 200 mg|DRUG: Cisplatin 75 mg/m^2|DRUG: Pemetrexed 500 mg/m^2|DRUG: Carboplatin AUC 5 mg/mL/min|DRUG: Carboplatin AUC 6 mg/mL/min|DRUG: Paclitaxel 200 mg/m^2|DRUG: Nab-paclitaxel 100 mg/m^2|BIOLOGICAL: Ipilimumab 1 mg/kg|DRUG: Etoposide 100 mg/m^2|DRUG: G-CSF (pegfilgrastim) 3.6 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Mindfulness Education in Primiparous Pregnant Women
Status: UNKNOWN
Conditions: Pregnancy Related|Mindfulness|Fear of Childbirth|Attitude
Interventions: BEHAVIORAL: Mindfulness education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Oral Care Protocol for the Management of Chemotherapy and Radiation Therapy-Induced Oral Mucositis
Status: COMPLETED
Conditions: Oral Mucositis|Oral Cancer
Interventions: PROCEDURE: Oral Mucosa Deterging and Periodontal Debridement (OMDP)|PROCEDURE: Standard of Care Oral Hygiene Instructions|PROCEDURE: Dental scaling, ultrasonic|OTHER: Chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Ribavirin on the Initial Virological Response in Treatment Naïve Patients With Hepatitis C Genotype 1 Infection
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Pegylated Interferon (PEG-IFN) alfa-2a|DRUG: Placebo|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Uterine Irrigation Method in Infertility Patients Who Require PGD
Status: UNKNOWN
Conditions: Pre-Implantation Embryo Recovery|Genetic Diseases, Inborn
Interventions: DEVICE: Uterine Lavage Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC