pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Clinical and Economic Consequences of Left Atrial Bipolar Radiofrequency Ablation of Persistent and Permanent Atrial Fibrillation During Cardiac Surgery
Status: TERMINATED
Conditions: Atrial Fibrillation|Coronary Artery Disease
Interventions: PROCEDURE: bipolar radiofrequency ablation of persistent and permanent AF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Study of SHR-1701 Plus Chemotherapy as Perioperative Treatment in Subjects With Gastric Cancer
Status: TERMINATED
Conditions: Perioperative Treatment in Subjects With Locally Advanced Resectable Gastric Cancer or Gastroesophageal Junction Cancer
Interventions: DRUG: SHR-1701 injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Mesenteric Venous Thrombosis.. in Assiut University Hospital Management Controversies
Status: UNKNOWN
Conditions: Mesenteric Vein Thrombosis
Interventions: DRUG: Warfarin|PROCEDURE: MVT with failure of anticoagulation therapy|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maintenance of Platelet Inhibition With Cangrelor
Status: COMPLETED
Conditions: Acute Coronary Syndrome (ACS)
Interventions: DRUG: cangrelor|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Utility of Versican and Hyaluronan Measurement in Induced Sputum as Biomarkers of Asthma
Status: COMPLETED
Conditions: Allergic Asthma
Interventions: DRUG: Inhaled corticosteroid (fluticasone)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Benign Acute Pericarditis: Brief Versus Longer Treatment Using Aspirin
Status: TERMINATED
Conditions: Pericarditis
Interventions: DRUG: Aspirin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyper- and Hypokalemic Periodic Paralysis Study
Status: COMPLETED
Conditions: Hyperkalemic Periodic Paralysis|Hypokalemic Periodic Paralysis
Interventions: DRUG: Dichlorphenamide (double-blind)|DRUG: Placebo (double-blind)|DRUG: Dichlorphenamide (open-label)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effects of Tasimelteon in Individuals With Autism Spectrum Disorder (ASD) and Sleep Disturbances
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Sleep Disorder|Neurological Disorder|Sleep Disturbance
Interventions: DRUG: Tasimelteon Oral Capsule, Tasimelteon Liquid Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TDT 067 Onychomycosis Study
Status: UNKNOWN
Conditions: Onychomycosis
Interventions: DRUG: TDT067|DRUG: Placebo|DRUG: Transfersome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Vitamin C on Hyperoxia-Induced Reduction of Retinal Blood Flow
Status: COMPLETED
Conditions: Ocular Physiology|Regional Blood Flow
Interventions: DIETARY_SUPPLEMENT: vitamin C (Mayrhofer) 24mg/min i.v. for 64 min|DIETARY_SUPPLEMENT: Placebo|OTHER: 100% O2 (AGA) two times for 12 min
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: COMPARISON OF INTRAOPERATIVE LOCAL ANESTHETIC APPLICATIONS IN POSTOPERATIVE PAIN MANAGEMENT IN LAPAROSCOPIC CHOLECYSTECTOMY PATIENTS
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 2 Study of Oral MKC-1 in Patients With Ovarian or Endometrial Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Endometrial Cancer
Interventions: DRUG: MKC-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Biophysical Stimulation on Intraspongious Bone Edema in Anterior Cruciate Ligament Reconstruction
Status: COMPLETED
Conditions: ACL Injury|Pain|Magnetic Field Exposure
Interventions: DEVICE: I-ONE® therapy|DRUG: Anti-inflammatory drug
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Devices for Reflex Voiding Following Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury|Urinary Incontinence
Interventions: DEVICE: Vibrator|PROCEDURE: Anal dilator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: DBS of the Lateral Habenula in Treatment-Resistant Depression
Status: ACTIVE_NOT_RECRUITING
Conditions: Treatment Resistant Major Depressive Disorder
Interventions: DEVICE: Activa Tremor Control Sys (DBS Implant)|OTHER: Randomized, staggered withdrawal phase
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BEP Supplementation Research in Bangladesh (JiVitA-BEP-IR)
Status: RECRUITING
Conditions: Fetal Growth Retardation|Low Birth Weight|Preterm Birth|Gestational Weight Gain|Anemia of Pregnancy|Stunting|Pregnancy Complications
Interventions: DIETARY_SUPPLEMENT: Balanced energy and protein supplement for pregnant women|DIETARY_SUPPLEMENT: Multiple Micronutrient Supplement for pregnant women
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of 2 Tests to Diagnose Cognitive Dysfunctions in Alcohol Disease
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: OTHER: MoCA (Montreal Cognitive Assessment) test|OTHER: BEARNI (Brief Evaluation of Alcohol Related Neuropsychological Impairment) Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Milgamma® and Milgamma® Compositum Step-therapy in Patients With Acute Non-specific Low Back Pain Receiving Modern NSAID
Status: COMPLETED
Conditions: Acute Non-specific Low Back Pain
Interventions: DRUG: Exposure of interest (within routine clinical practice):Vitamin B complexes Milgamma® and Milgamma® compositum
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of CRS-207 With Epacadostat in Platinum Resistant Ovarian, Fallopian or Peritoneal Cancer
Status: TERMINATED
Conditions: Platinum-resistant Ovarian Cancer|Platinum-resistant Fallopian Cancer|Platinum-resistant Peritoneal Cancer
Interventions: BIOLOGICAL: CRS-207|DRUG: Epacadostat|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiotherapy Versus Use of a New Ankle Trainer Device After Ankle Fracture Operation.
Status: COMPLETED
Conditions: Ankle Fracture - Lateral Malleolus|Post-Op Complication
Interventions: DEVICE: Ankle trainer device|OTHER: Conventional physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SC IL-1Ra in SAH - Phase III Trial (SCIL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Subarachnoid Hemorrhage
Interventions: DRUG: IL-1Ra|DRUG: IL-1Ra Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Ultrasound Guided PECS Block on Opioid Consumption and Patient Satisfaction Through Adequate Pain Control Following Breast Cancer Surgery.
Status: RECRUITING
Conditions: Breast Neoplasm Female|Pain, Postoperative|Pain|Analgesia|Anaesthesia|Breast Cancer
Interventions: PROCEDURE: PECS Block|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intelligent Intensive Care Unit
Status: ACTIVE_NOT_RECRUITING
Conditions: Delirium|Confusion
Interventions: BEHAVIORAL: Confusion Assessment Method|DEVICE: Accelerometer|DEVICE: Commercially available camera|DEVICE: Internet Pod (iPod)|DIAGNOSTIC_TEST: Cortisol Swab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacity Assessment of PREVADH® in Adhesion Prevention in Gynaecologic Surgery
Status: COMPLETED
Conditions: Uterine Fibroids|Fertility Disorders
Interventions: OTHER: Ringer lactate solution|DEVICE: Prevadh film
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 5-hydroxytryptophan and Creatine for Treatment Resistant Depression Associated With Hypoxia in Females
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: 5-hydroxytryptophan and Creatine monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medical Therapy Versus Radiofrequency Endometrial Ablation in the Initial Treatment of Menorrhagia
Status: COMPLETED
Conditions: Menorrhagia
Interventions: DRUG: Estradiol 30mcg / Levonorgestrel 150mcg monophasic oral contraceptive pills|DRUG: Naproxen sodium pills|DEVICE: NovaSure® Radiofrequency Endometrial Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 23 Gauge and 20 Gauge Vitrectomy for Rhegmatogenous Retinal Detachments
Status: COMPLETED
Conditions: Retinal Detachment
Interventions: PROCEDURE: Retinal Detachment repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of a Smartphone-based Screening Tool (Picterus JP) for Neonatal Jaundice (Chicago)
Status: RECRUITING
Conditions: Neonatal Jaundice
Interventions: DEVICE: Picterus Jaundice Pro (JP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas
Status: COMPLETED
Conditions: Adult Brain Tumor|Adult Brain Stem Glioma|Adult Diffuse Astrocytoma|Adult Ependymoma|Adult Grade II Meningioma|Adult Melanocytic Lesion|Adult Meningeal Hemangiopericytoma|Adult Mixed Glioma|Adult Oligodendroglioma|Adult Pineal Gland Astrocytoma|Adult Pineocytoma|Recurrent Adult Brain Tumor
Interventions: RADIATION: proton beam radiation therapy|PROCEDURE: quality-of-life assessment|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of AG-80308 in Dry Eye Patients
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: AG-80308
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study in Patients Suffering From Knee Osteoarthritis
Status: WITHDRAWN
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Chondroitin sulfate and sodium hyaluronate|DRUG: Hyaluronan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Early Stress-Reduction Intervention in Patients With Newly Diagnosed Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Neoplasm of Breast
Interventions: BEHAVIORAL: Mind-Body Exercises|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pilot Clinical Trial of Varenicline as a Treatment for Alcohol Dependence
Status: COMPLETED
Conditions: Substance Dependence
Interventions: DRUG: varenicline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical and Genomic Responses to Open Heart Surgery
Status: COMPLETED
Conditions: Ischemia-reperfusion (IR) Injury
Interventions: PROCEDURE: Remote ischemic preconditioning (RIPC)|PROCEDURE: SHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Safety and Efficacy of TU-100 as an Adjunct to an Enhanced Recovery After Surgery in Subjects Undergoing Bowel Resection
Status: COMPLETED
Conditions: Enhanced Recovery After Surgery
Interventions: DRUG: TU-100|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study of Nusinersen (BIIB058) in Participants With Spinal Muscular Atrophy Who Previously Participated in a Study With Nusinersen
Status: ENROLLING_BY_INVITATION
Conditions: Muscular Atrophy, Spinal
Interventions: DRUG: Nusinersen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Walking Intervention on Impact Loading and Pain
Status: UNKNOWN
Conditions: Osteoarthritis, Knee|Knee Pain Chronic
Interventions: BEHAVIORAL: Progressive Walking with Gait Retraining|BEHAVIORAL: Progressive Walking Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Efficacy and Safety of Tacrolimus With Steroids or Monoclonal Anti-IL2R Antibody in Hepatitis C Virus (HCV) Positive Liver Transplant Patients
Status: COMPLETED
Conditions: Hepatitis C|Liver Transplantation
Interventions: DRUG: Tacrolimus|DRUG: steroids, monoclonal anti-IL2R antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Supplementation With Omega-3: Mechanism of Action
Status: TERMINATED
Conditions: Hypertriglyceridemia
Interventions: DIETARY_SUPPLEMENT: DHA-enriched|DIETARY_SUPPLEMENT: EPA-enriched
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Coping Strategies on the Control of Chronic Non-Cancer Pain and Quality of Life (CNCP_CopQol)
Status: UNKNOWN
Conditions: Chronic Pain|Musculoskeletal Diseases|Quality of Life|Pain Measurement
Interventions: BEHAVIORAL: Psychoeducative intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Autologous Engineered Skin Substitute to Treat Partial- and Full-Thickness Burn Wounds
Status: UNKNOWN
Conditions: Thermal Injury|Deep Partial-Thickness Burn|Full-Thickness Burn
Interventions: DRUG: Autologous Engineered Skin Substitute|DRUG: Split-Thickness Autograft (AG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Path to Optimal Black Maternal Heart Health: Comparing Two CVD Risk Reduction Interventions (Change of HEART)
Status: RECRUITING
Conditions: Pregnancy Related|Hypertension|Obesity|Racism
Interventions: BEHAVIORAL: COH|BEHAVIORAL: COH+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Voxilaprevir in Adults With Normal Hepatic Function and Moderate or Severe Hepatic Impairment
Status: COMPLETED
Conditions: HCV Infection
Interventions: DRUG: Voxilaprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Follow-up of Children Born in the PETN Studies
Status: RECRUITING
Conditions: Intrauterine Growth Restriction|Pentaerithrityl Teratnitrate in Pregnancy|Long-Term Effects to Children
Interventions: BEHAVIORAL: Questionnaire Child Behaviour Checklist|BEHAVIORAL: Questionnaire Young Self Report|DIAGNOSTIC_TEST: physical examination|DIAGNOSTIC_TEST: metabolic examination|BEHAVIORAL: Questionnaire Reynolds Intellectual Assessment Scales and Screening|DIAGNOSTIC_TEST: electroencephalogram|OTHER: Questionnaire Movement Assessment Battery for Children|OTHER: Questionnaire Continuous Performance Test|OTHER: Questionnaire Diagnostic System for Mental Disorders|DIAGNOSTIC_TEST: kidney function tests|OTHER: Questionnaire Five to Fifteen|DIAGNOSTIC_TEST: cardiovacular examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Effects of Jandas's Approach With and Without Post Isometric Relaxation Technique
Status: NOT_YET_RECRUITING
Conditions: PELVIS Syndrome
Interventions: OTHER: Janda's Approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Psychosocial Risk Factors in Stroke and Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction|Stroke
Interventions: BIOLOGICAL: blood sample|BEHAVIORAL: questionnaires for psychosocial factors
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Continous Renal Replacement Therapy With the CARPEDIEM® in a French National Cohort of 25 Neonates and Small Infants
Status: COMPLETED
Conditions: Hypoxic-Ischemic Encephalopathy|Sepsis|Kidney Diseases|Metabolic Disease|Twin to Twin Transfusion Syndrome|Cardiac Disease|Pulmonary Disease
Interventions: DEVICE: CARPEDIEN
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Continuous Ultrasound Guided Erector Spinae Plane Block vs Thoracic Paravertebral Block
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: OTHER: continuous Thoracic paravertebral block|OTHER: continuous Erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Virtual Reality for Alleviation of Peripheral IV Placement-Associated Discomfort
Status: UNKNOWN
Conditions: Procedural Anxiety|Procedural Pain|Perioperative Care
Interventions: DEVICE: Virtual reality|PROCEDURE: Peripheral intravenous catheter placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cellulitis Optimal Antibiotic Treatment
Status: NOT_YET_RECRUITING
Conditions: Cellulitis of Leg
Interventions: DRUG: Flucloxacillin Only Product in Oral Dose Form|DRUG: Placebo Only Product in Oral Dose Form
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Supportive Care on the Experience of Hospitalization of Patients Staying in the Protected Area of the Department of Blood Diseases
Status: RECRUITING
Conditions: Acute Leukemia|Hematopoietic Stem Cell Transplantation (SCT)|Aplasia
Interventions: OTHER: Aesthetic therapy sessions|OTHER: Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac Arrest
Status: RECRUITING
Conditions: Heart Arrest|Seizures|Status Epilepticus
Interventions: DRUG: Perampanel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bone Marrow Stem Cells as a Source of Allogenic Hepatocyte Transplantation in Homozygous Familial Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia, Familial
Interventions: PROCEDURE: Cellular transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Treatment PERSOnalization Based on Its Therapeutic Monitoring in Patients With Metastatic Colorectal Cancer Treated With REgorafenib
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer Metastatic
Interventions: DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Mindfulness-Based Pregnancy Education Program on Stress, Birth Fear and Birth Self-Efficacy in Pregnants
Status: COMPLETED
Conditions: Mindfulness|Pregnancy|Stress|Childbirth|Midwife
Interventions: BEHAVIORAL: mindfulness-based pregnancy education program.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Double-Blind, Placebo-Controlled Trial of Anti-Aging, Pro-Autophagy Effects of Metformin in Adults With Prediabetes
Status: COMPLETED
Conditions: PreDiabetes|Aging
Interventions: DRUG: Metformin|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrated Prevention and Collaborative Care for Youth Mental Health
Status: UNKNOWN
Conditions: Mental Disorders|Substance-Related Disorders|Quality of Life
Interventions: BEHAVIORAL: Preventure program|BEHAVIORAL: Equipe program|BEHAVIORAL: Inter-Action services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Subcutaneous ICD Therapy Combined With VT Ablation for the Secondary Prevention of Sudden Cardiac Death
Status: UNKNOWN
Conditions: Sudden Cardiac Death
Interventions: DEVICE: Subcutaneous ICD Therapy Combined with VT Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does the Mesh Have to be Fixed in Laparoscopic eTEP Repair of Bilateral Inguinal Hernia?
Status: COMPLETED
Conditions: Migration of Implant|Pain|Postoperative Complications|Relapse
Interventions: PROCEDURE: TEP group|PROCEDURE: eTEP group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Surgical Methods for Persistent Atrial Fibrillation Combined With the Application of Statin Drugs on Left Atrial Function
Status: COMPLETED
Conditions: Persistent Atrial Fibrillation
Interventions: PROCEDURE: Cryoballoon ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A New Drug for Benign Prostatic Hyperplasia (BPH) Compared With Placebo
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia (BPH)
Interventions: DRUG: Silodosin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Zidovudine (AZT) and Stavudine in HIV-Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Stavudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Optimization of the Ocular Surface Prior to Cataract Surgery Using PROKERA
Status: UNKNOWN
Conditions: Cataract|Dry Eye Syndromes|Cataract Senile|Dry Eye
Interventions: DEVICE: PROKERA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Supplementation of Sucrosomal Iron as Hematopoietic Support.
Status: UNKNOWN
Conditions: Anemia, Iron-Deficiency
Interventions: DIETARY_SUPPLEMENT: Oleovital® Eisen Forte
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pegylated Liposomal Doxorubicin Hydrochloride With Atezolizumab and/or Bevacizumab in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Fallopian Tube High Grade Serous Adenocarcinoma|Ovarian High Grade Serous Adenocarcinoma|Ovarian Seromucinous Carcinoma|Primary Peritoneal High Grade Serous Adenocarcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Fallopian Tube Clear Cell Adenocarcinoma|Recurrent Fallopian Tube Endometrioid Adenocarcinoma|Recurrent Fallopian Tube Undifferentiated Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Ovarian Clear Cell Adenocarcinoma|Recurrent Ovarian Endometrioid Adenocarcinoma|Recurrent Ovarian Undifferentiated Carcinoma|Recurrent Platinum-Resistant Fallopian Tube Carcinoma|Recurrent Platinum-Resistant Ovarian Carcinoma|Recurrent Platinum-Resistant Primary Peritoneal Carcinoma|Recurrent Primary Peritoneal Carcinoma|Recurrent Primary Peritoneal Clear Cell Adenocarcinoma|Recurrent Primary Peritoneal Endometrioid Adenocarcinoma|Recurrent Primary Peritoneal Undifferentiated Carcinoma
Interventions: DRUG: Atezolizumab|BIOLOGICAL: Bevacizumab|PROCEDURE: Computed Tomography|DRUG: Pegylated Liposomal Doxorubicin Hydrochloride|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Muslim Americans Reaching for Health and Building Alliances (MARHABA): Patient Navigation Intervention to Increase Breast and Cervical Cancer Screening Among Muslim Women in New York City
Status: COMPLETED
Conditions: Breast Cancer|Cervical Cancer
Interventions: BEHAVIORAL: SM-LHW|BEHAVIORAL: PN-LHW
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Antalgic Treatment of Painful Bone Metastases by US-guided High Intensity Focused Ultrasound (HIFU)
Status: COMPLETED
Conditions: Bone Metastasis
Interventions: DEVICE: HIFU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Study With MT-102 in Subjects With Cancer Cachexia
Status: COMPLETED
Conditions: Cancer Cachexia
Interventions: DRUG: MT-102
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of a Tailored Model for Implementation of Injury Prevention Training in Youth Handball (the I-PROTECT Model)
Status: COMPLETED
Conditions: Athletic Injuries
Interventions: BEHAVIORAL: I-PROTECT model|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficacy and Safety Between Two Antiretroviral Regimens, in HIV-1-infected Treatment-naïve Subjects With Low CD4 Counts
Status: COMPLETED
Conditions: HIV-1 Infection|Immunosuppression-related Infectious Disease
Interventions: DRUG: DARUNAVIR|DRUG: ATAZANAVIR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CM313 Injection in Subjects With Systemic Lupus Erythematosus
Status: UNKNOWN
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: CM313 2 mg/kg|BIOLOGICAL: CM313 4 mg/kg|BIOLOGICAL: CM313 8 mg/kg|BIOLOGICAL: CM313 16 mg/kg|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carboplatin and Paclitaxel With or Without Panitumumab in Treating Patients With Invasive Triple Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Carcinoma|Breast Lump|Edema|Erythema|Estrogen Receptor Negative|HER2/Neu Negative|Inflammatory Breast Carcinoma|Invasive Breast Carcinoma|Peau d'Orange|Progesterone Receptor Negative|Triple-Negative Breast Carcinoma
Interventions: DRUG: Carboplatin|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel|BIOLOGICAL: Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Assessment and Intervention for Adolescents at Risk for Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder|Early Intervention
Interventions: BEHAVIORAL: Interpersonal and Social Rhythm Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Efficacy of a Vasopressin 2 Receptor Antagonist M0002 for Treatment of Ascites in Cirrhotic Subjects With Hypo- or Normonatraemia
Status: COMPLETED
Conditions: Cirrhotic Ascites
Interventions: DRUG: M0002|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PG2 Treatment for Improving Fatigue Among Advanced Cancer Patients Under Standard Palliative Care
Status: COMPLETED
Conditions: Fatigue
Interventions: DRUG: PG2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clofarabine Salvage Therapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Bilastine Ophthalmic Solution 0.6% in the Conjunctival Allergen Challenge (Ora-CAC®) Model.
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: Bilastine Ophthalmic Solution 0.6%|DRUG: Ketotifen Ophthalmic Solution 0.025% (Zaditen)|DRUG: Vehicle of Bilastine Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Plasma Trimethylamine N-oxide Elevation Induced by L-carnitine Supplementation and Insulin Resistance
Status: SUSPENDED
Conditions: Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: L-carnitine|DIETARY_SUPPLEMENT: L-leucine|BEHAVIORAL: Change of the circadian cycle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Sage Essential Oil Inhalation Aromatherapy on Premenstrual Symptoms and Quality of Life
Status: NOT_YET_RECRUITING
Conditions: Premenstrual Syndrome|Anxiety
Interventions: OTHER: sage essential oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Cluster-randomized Trial to EValuate the Efficacy of Wolbachia-InfecTed Aedes Aegypti Mosquitoes in Reducing the Incidence of Arboviral Infection in Brazil (EVITA Dengue)
Status: RECRUITING
Conditions: Dengue Fever
Interventions: OTHER: Brazilian National Dengue Control Program|OTHER: Wolbachia-infected Aedes aegypti
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Health Economics Evaluation of Percutaneous Vertebroplasty Compared to Radiation Therapy in Patients With Painful Spine Metastases.
Status: TERMINATED
Conditions: Spine Metastases
Interventions: RADIATION: External radiotherapy|PROCEDURE: Percutaneous vertebroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Longvida Curcumin Human Pharmacokinetics Study
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Treatment1|DIETARY_SUPPLEMENT: Treatment2|DIETARY_SUPPLEMENT: Treatment3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Perioperative Neurocognitive Disorders With Olfactory Enrichment
Status: RECRUITING
Conditions: Perioperative Neurocognitive Disorder
Interventions: OTHER: Olfactory Enrichment|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Exosomes Versus Platelet Rich Plasma in Patients of Androgenetic Alopecia
Status: RECRUITING
Conditions: Androgenetic Alopecia
Interventions: BIOLOGICAL: Exosomes GFC CELL EXO SCALP KIT (Leuco Exo 97%)|BIOLOGICAL: Platelet Rich Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study to See How Well New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Levels in People With Type 2 Diabetes (T2D), Compared to Daily Insulin Glargine (COMBINE 4)
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: IcoSema|DRUG: Insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety of Anti-viral Therapy in Preventing HBV MTCT in Pregnant Women After Discontinuation
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Telbivudine 600mg|DRUG: Tenofovir disoproxil fumarate 300mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial to Evaluate the Food Effect on Pharmacokinetic Profiles and Safety of CKD-379
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: CKD-379(Empagliflozin+sitagliptin+metformin) Test drug|DRUG: CKD-379(Empagliflozin+sitagliptin+metformin) Reference drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An African, Multi-centre Evaluation of Patient Care and Clinical Outcomes for Paediatric Patients Undergoing Surgery
Status: COMPLETED
Conditions: Paediatric Surgery|Perioperative/Postoperative Complications|Perioperative Outcomes|Hospital Mortality|Developing Countries|Outcome Assessment|Paediatrics|Prospective Studies|Surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Drug-Drug Interaction Study to Assess the Pharmacokinetics of DC-806 When Orally Administered Alone, When Coadministered With Itraconazole, and When Coadministered With Carbamazepine in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: DC-806|DRUG: Itraconazole|DRUG: Carbamazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Human Immune Response to Ixodes Scapularis Tick Bites
Status: RECRUITING
Conditions: Tick-borne Diseases|Tick Resistance|Lyme Disease
Interventions: DEVICE: Xenodiagnosis Ticks|PROCEDURE: skin biopsy|PROCEDURE: blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Surgical Approaches in Treating Uncontrolled Glaucoma in Black African and African-Caribbeans
Status: UNKNOWN
Conditions: Primary Open Angle Glaucoma
Interventions: PROCEDURE: Trabeculectomy|DEVICE: Baerveldt tube surgery|DRUG: mitomycin-C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Investigating the Clinical Use of Tissue Engineered Vascular Grafts in Congenital Heart Surgery
Status: COMPLETED
Conditions: Single Ventricle Cardiac Anomaly
Interventions: COMBINATION_PRODUCT: Tissue Engineered Vascular Grafts
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Guide in Active Older Adult Men
Status: COMPLETED
Conditions: Men|Diet Modification|Obesity|Overweight|Life Style|Weight Loss
Interventions: DIETARY_SUPPLEMENT: NCDsport|DIETARY_SUPPLEMENT: LCDsport
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Vitrectomy Without Internal Limiting Membrane Peeling Versus Inverted ILM Flap Technique for Macular Hole Retinal Detachment in Highly Myopic Eyes
Status: COMPLETED
Conditions: Macular Holes|Retina Detachment
Interventions: PROCEDURE: vitrectomy with or without inverted ILM flap technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2b Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease in Patients Taking Levodopa
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Istradefylline|DRUG: Istradefylline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drospirenone/Ethinyl Estradiol (3 mg/0.02 mg) Tablets Under Non-Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Drospirenone/Ethinyl Estradiol (Gianvi®)|DRUG: YAZ®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy and Safety of TAF in Pregnant Women With Chronic Hepatitis B Infection
Status: UNKNOWN
Conditions: Chronic Hepatitis B|Mother-to-child Block|Antiviral Treatment
Interventions: DRUG: Tenofovir Alafenamide 25 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: CD24Fc With Ipilimumab and Nivolumab to Decrease irAE (CINDI)
Status: WITHDRAWN
Conditions: Metastatic Melanoma
Interventions: DRUG: CD24Fc|DRUG: Ipilimumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Statin-induced Lipid-rich Plaque Progression by Optical Coherence Tomography (OCT) Combined With Intravascular Ultrasound (IVUS)
Status: COMPLETED
Conditions: Coronary Artery Disease|Hyperlipidemia
Interventions: DRUG: Atorvastatin|DRUG: Atorvastatin|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of an Intervention to Prevent Frailty in Obese Elderly People (PRE-FROB)
Status: COMPLETED
Conditions: Fragility|Sarcopenia|Obese|Elderly
Interventions: OTHER: Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Transcranial Brain Stimulation and Its Underlying Neural Mechanisms as a Novel Treatment for Auditory Hallucinations
Status: COMPLETED
Conditions: Psychotic Disorders
Interventions: DEVICE: DC Stimulator PLUS (NeuroConn)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Directly Administered Antiretroviral Therapy (DAART) Among HIV-1infected Injecting Drug Users (IDUs) in Chennai, India
Status: WITHDRAWN
Conditions: HIV Infections|Heroin Dependence
Interventions: BEHAVIORAL: Directly Administered Antiretroviral Therapy (DAART)|BEHAVIORAL: SAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Nivolumab Compared to Docetaxel in Subjects Previously Treated With Advanced or Metastatic Non Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Nivolumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endothelial Function in Lower Extremity Bypass Grafts
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DRUG: L-N^G monomethyl arginine (L-NMMA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Dry Age Related Macular Degeneration Disease With Retinal Pigment Epithelium Derived From Human Embryonic Stem Cells
Status: UNKNOWN
Conditions: Dry Age-related Macular Degeneration
Interventions: BIOLOGICAL: retinal pigment epithelium transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: ACT MALI: Treatment of Malaria Based on Combination Therapies
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Artesunate|DRUG: Artesunate + Sulfadoxine-Pyrimethamine|DRUG: arthemether + lumefantrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-exposure Prophylaxis (PrEP) Adherence Intervention for Women With Substance Use Disorders
Status: RECRUITING
Conditions: Substance Use
Interventions: BEHAVIORAL: Addiction Clinic-Based PrEP Adherence Intervention for Women with Substance Use Disorders|OTHER: Standard of care treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Efficiency of FOLFIRI as Seconde-line Chemotherapy in Neuroendocrine Carcinoma
Status: UNKNOWN
Conditions: Neuroendocrine Carcinoma
Interventions: DRUG: FOLFIRI Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Oral APL-1202 in Combination With Tislelizumab Compared to Tislelizumab Alone as Neoadjuvant Therapy in Patients With Muscle Invasive Bladder Cancer
Status: UNKNOWN
Conditions: Muscle Invasive Bladder Cancer
Interventions: DRUG: APL-1202 in combination with tislelizumab|DRUG: Tislelizumab alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prefatory Study to Explore Changes in Nasal Mucociliary Clearance and to Standardize Nasal Scraping Procedure
Status: COMPLETED
Conditions: Smokers|Never Smokers
Interventions: OTHER: Cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Cholestyramine in the Management of Hyperphosphatemia in Adult Hemodialysis Patients
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Hemodialysis Complication|Hyperphosphatemia
Interventions: DRUG: Cholestyramine Resin 4000 MG [Questran]|DRUG: Calcium Carbonate 500 MG Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concordance in Diagnosis of Periodontitis in Diabetic Patients Between an Indirect Method Based on a Photograph of the Oral Cavity and a Direct Method Based on the Clinical Examination of This Oral Cavity (Reference).
Status: RECRUITING
Conditions: Diabetes Complications|Periodontal Diseases
Interventions: DIAGNOSTIC_TEST: Front view photography of the patient's oral cavity with the help of a smartphone in the diabetology department.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Performance Evaluation of AirWay Medix Closed Suction System Compared With a Standard Closed Suction System
Status: UNKNOWN
Conditions: Endotracheal Tube|Mechanical Ventilation
Interventions: DEVICE: AirWay Medix Closed Suction System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Orally Administered BGC20-0134 (Structured Lipid) in Patients With Relapsing Remitting Multiple Sclerosis (RRMS)
Status: TERMINATED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: Pleneva TM BGC20-0134|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3537021 in Healthy Participants and Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Healthy|Type 2 Diabetes Mellitus
Interventions: DRUG: LY3537021|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE