pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Baricitinib Versus Azathioprine in Patients With Moderate-to-Severe Atopic Dermatitis
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: Baricitinib 4 MG|DRUG: Azathioprine 1.5-2.5 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindfulness in University Students. ATENEU Program
Status: RECRUITING
Conditions: Occupational Balance|Mental Health Wellness|University Students|Burnout, Student
Interventions: BEHAVIORAL: Mindfulness program|BEHAVIORAL: Mindfulness program with Virtual Reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: is There an Alternative to Ultrasound Guided Interscalene Block?
Status: UNKNOWN
Conditions: Regional Anesthesia|Interscalene Block|Shoulder Surgery
Interventions: DRUG: bupivacaine|DEVICE: ultrasound|DRUG: morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short-course Radiation Followed by mFOLFOX-6 Plus COMPOUND 2055269 for Locally-advanced Rectal Adenocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Rectal Cancer
Interventions: DRUG: COMPOUND 2055269|RADIATION: Radiation Therapy|DRUG: mFOLFOX|PROCEDURE: Total Mesorectal Excision
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Thorough QT/QTc Study to Assess the Effects of Androxal in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Androxal 25 mg capsules|DRUG: Androxal 250 Capsules|DRUG: Placebo Capsules|DRUG: Moxifloxacin 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study of VAC85135, a Neoantigen Vaccine Regimen, Concurrently Administered With Ipilimumab for the Treatment of Myeloproliferative Neoplasms
Status: ACTIVE_NOT_RECRUITING
Conditions: Myeloproliferative Neoplasms
Interventions: BIOLOGICAL: VAC85135|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pea Hull Fibre Supplementation
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Pea Fiber|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective, Multicenter Study of the OMNI® Surgical System in Pseudophakic Eyes With Open Angle Glaucoma
Status: TERMINATED
Conditions: Glaucoma, Open-Angle
Interventions: DEVICE: OMNI® Surgical System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tea Components, Mental Stress and Blood Pressure
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Combination of caffeine and theanine|OTHER: Caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Mindfulnes Program on Stress, Depression and Psychological Well-being in Cancer Patients
Status: COMPLETED
Conditions: Neoplasms|Cancer
Interventions: OTHER: Mindfulness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Effectiveness Evaluation of the Multi-Electrode Radiofrequency Balloon Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Multi-Electrode RF Balloon Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: APX005M With Nivolumab and Cabiralizumab in Advanced Melanoma, Non-small Cell Lung Cancer or Renal Cell Carcinoma
Status: COMPLETED
Conditions: Advanced Melanoma|Non-small Cell Lung Cancer|Renal Cell Carcinoma
Interventions: DRUG: APX005M|DRUG: Cabiralizumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous Golimumab (GLM) Plus DMARDs for Rheumatoid Arthritis, Followed by Intravenous/Subcutaneous GLM Strategy (P06129 AM2)
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: BIOLOGICAL: SC golimumab|BIOLOGICAL: IV golimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid Point-of-care Testing for Hepatitis C in Community Clinics (RAPID-EC) Pilot Study
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DEVICE: OraQuick HCV Ab test|DEVICE: Xpert HCV viral load test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phenylbutyrate and Valganciclovir in Treating Patients With Relapsed or Refractory Epstein-Barr Virus-Positive Cancer
Status: WITHDRAWN
Conditions: Gastric Cancer|Head and Neck Cancer|Lymphoma|Lymphoproliferative Disorder
Interventions: DRUG: oral sodium phenylbutyrate|DRUG: valganciclovir|GENETIC: polymerase chain reaction|GENETIC: protein expression analysis|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravesical Lidocaine on Urodynamic and Symptomatic Parameters of Interstitial Cystitis
Status: WITHDRAWN
Conditions: Interstitial Cystitis
Interventions: PROCEDURE: Urodynamic study|DRUG: Lidocaine|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: An Intra-individual Titration Study of KRN1493 for the Treatment of Hypercalcemia in Patients With Parathyroid Carcinoma or Intractable Primary Hyperparathyroidism
Status: COMPLETED
Conditions: Parathyroid Carcinoma|Hypercalcemia|Primary Hyperparathyroidism
Interventions: DRUG: Cinacalcet HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ultrasound Guided PIFB Versus Lidocaine Infusion on Postoperative Pain After Thoracotomy
Status: RECRUITING
Conditions: Cardiac Surgery
Interventions: PROCEDURE: pecto intercostal fascial block using bupivacaine 0.25%|DRUG: lidocaine infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Maintenance Lurbinectedin in Combination With Serplulimab for Patients With ES-SCLC
Status: NOT_YET_RECRUITING
Conditions: Extensive-Stage Small Cell Lung Cancer
Interventions: DRUG: Serplulimab|DRUG: Lurbinectedin|DRUG: Carboplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of LY3437943 Given as a Single Injection in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3437943|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Steroids and/ or Non-steroidal Anti-inflammatory Drugs in the Postoperative Regime After Trabeculectomy.
Status: ACTIVE_NOT_RECRUITING
Conditions: Glaucoma
Interventions: DRUG: Voltaren Ophtha 1 mg/ml, GSK|DRUG: Monopex 1 mg/ml, Théa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: DHA and X-Linked Retinitis Pigmentosa
Status: COMPLETED
Conditions: Retinitis Pigmentosa|X-linked Genetic Diseases
Interventions: DRUG: docosahexaenoic acid OR corn/soy oil placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Abscopal Effect for Metastatic Non-small Cell Lung Cancer.
Status: WITHDRAWN
Conditions: Non-small Cell Lung Cancer|Metastatic Non-small Cell Lung Cancer|Radiotherapy|Thymalfasin
Interventions: RADIATION: Radiotherapy|DRUG: Thymalfasin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PURO - PUlmonary Rehabilitation With O-RAGT Platform
Status: COMPLETED
Conditions: Multiple Sclerosis|Spinal Cord Injury|Stroke|Traumatic Brain Damage
Interventions: DEVICE: UANGO suite exoskeleton
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Computer Guided Versus Free Hand Horizontal Ridge Augmentation in Anterior Mandible.
Status: UNKNOWN
Conditions: Computer Guided Alveolar Bone Augmentaion
Interventions: PROCEDURE: computer guided autogenous cortical shell technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Oral Tofacitinib in Children Aged 2 to 17 Years Old Suffering From Moderate to Severe Ulcerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xylitol vs Saline Nasal Irrigations in CF-CRS
Status: ENROLLING_BY_INVITATION
Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: DEVICE: Nasal rinsing with saline 0.9%|DEVICE: Nasal rinsing with Xylitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Synergistic Effect of Portal Venous Supply Control and Immunotherapy in Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: COMBINATION_PRODUCT: PVE+cTACE+Camrelizumab+Apatinib|COMBINATION_PRODUCT: cTACE+Atirizumab+Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, PK, PD and Efficacy of AMG 827 in Adults With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Brodalumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Auricular Acupressure on the Methadone Patient
Status: COMPLETED
Conditions: Conditions:Effectiveness of Auricular Acupressure on the Methadone Patient
Interventions: OTHER: Auricular pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy of NOSHINtrial in Diabetic Patients
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2|Insulin Resistance
Interventions: DRUG: anti-diabetic herbal drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Breath Therapy and Emotional Freedom Technique on Public Speaking Anxiety
Status: UNKNOWN
Conditions: Public Speaking|Anxiety|Emotional Stress
Interventions: BEHAVIORAL: emotional freedom technique, breathing therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of rTMS on Cigarette Smoking and Cognition in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Nicotine Addiction
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)|DEVICE: Sham Repetitive Transcranial Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Midazolam or Dexmedetomidine on Epileptiform EEG During Sevoflurane Mask Induction
Status: UNKNOWN
Conditions: Inhalation Anesthesia
Interventions: DRUG: Placebos|DRUG: Midazolam|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TPI 287 in Breast Cancer Metastatic to the Brain
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: TPI 287|DRUG: Dexamethasone|DRUG: Benadryl|DRUG: Ranitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neural Mobilization and Cerebral Palsy
Status: NOT_YET_RECRUITING
Conditions: Cerebral Palsy|Neurologic Disorder
Interventions: PROCEDURE: Neural mobilization of the lower limb|PROCEDURE: Conventional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Safety and Efficacy of BOL-303259-X Ophthalmic Solution With Timolol Maleate Ophthalmic Solution in Subjects With Open-Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: BOL-303259-X|DRUG: Timolol|DRUG: BOL-303259-X
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A NEW MECHANICAL DECONTAMINATION METHOD IN PERI-IMPLANTITIS, TI-BRUSH, A RANDOMIZED CONTROLLED CLINICAL TRIAL
Status: COMPLETED
Conditions: Peri-Implantitis
Interventions: DEVICE: Titanium brush|OTHER: Classic decontamination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Lavender Inhalation on Dysmenorrhea
Status: RECRUITING
Conditions: Dysmenorrhea
Interventions: OTHER: Lavender oil inhalation|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetics of Hydrocortisone After Subcutaneous Administration in Chronic Adrenal Insufficiency
Status: COMPLETED
Conditions: Primary Adrenal Insufficiency
Interventions: DRUG: Hydrocortisone intramuscular first|DRUG: Hydrocortisone subcutaneously first
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Electrical Nerve Stimulation During Transvaginal Oocyte Retrieval
Status: COMPLETED
Conditions: Transcutaneous Electric Nerve Stimulation|Oocyte Retrieval
Interventions: DEVICE: Transcutaneous electrical nerve stimulation|DEVICE: TENS machine with electrodes not emitting any impulses.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D and Physical Activity on Bone Health
Status: ACTIVE_NOT_RECRUITING
Conditions: Bone Metabolism Biomarkers|Bone Mineral Density|Physical Fitness
Interventions: DRUG: Vitamin D3|BEHAVIORAL: Physical Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacodynamics of SYNB1020
Status: TERMINATED
Conditions: Cirrhosis
Interventions: DRUG: SYNB1020|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Histocompatibility Leukocyte Antigen (HLA)-A*2402 Restricted Peptide Vaccine Therapy in Patients With Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: BIOLOGICAL: URC10, TTK, KOC1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy and Temozolomide Followed by Temozolomide and Poly ICLC in Treating Patients With Newly Diagnosed GBM
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: poly ICLC|DRUG: temozolomide|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sodium Glucose Cotransporter 2 Inhibitiors on Left Ventricular Remodeling Among Diabetic and Non Diabetic Patients With Chronic Heart Failure
Status: NOT_YET_RECRUITING
Conditions: SGLT2 Inhibitiors Remodeling Effect|Chronic Heart Disease
Interventions: DRUG: Sodium-glucose cotransporter 2 inhibitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Low-Dose Hormone Replacement Therapy and Alendronate for Osteoporosis
Status: TERMINATED
Conditions: Osteopenia|Osteoporosis
Interventions: DRUG: Alendronate|DRUG: Estrogen/progestin therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Radiographical Evaluation of CAD-CAM Crowns With and Without Deep Margin Elevation
Status: RECRUITING
Conditions: Caries,Dental|Crown of Tooth With Poor Contour|Broken Teeth|Survival, Prosthesis|Failure, Prosthesis
Interventions: PROCEDURE: Deep margin elevation with composite resin and Lithium disilicate glass-ceramic crowns
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Discontinuation of Primary and Secondary Prophylaxis for Opportunistic Infections in HIV-infected Patients
Status: COMPLETED
Conditions: HIV Infection
Interventions: OTHER: Discontinuation of prophylactic drugs i.e. co-trimoxazole, dapsone, fluconazole, itraconazole, azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SMART Trial: Community Stigma Reduction
Status: COMPLETED
Conditions: Opioid-use Disorder|Stigma, Social
Interventions: BEHAVIORAL: Opioid Use Disorder Stigma Reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Interventional Study to Evaluate the Role of LRYGBP, LSG & SMM
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: PROCEDURE: Laparoscopic Roux en Y Gastric by pass surgery|PROCEDURE: Laparoscopic Sleeve Surgery|OTHER: Standard Medical Management
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Immediate Effectiveness of a 3D Intraoral Scanner as an Oral Hygiene Educational Tool
Status: COMPLETED
Conditions: Periodontal Diseases|Plaque Induced Gingival Disease
Interventions: DEVICE: Test: 3D intra-oral scanner|OTHER: Control: Standard oral hygiene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Biktarvy (B/F/TAF) on Whole-body Insulin Sensitivity, Lipid and Endocrine Profile in Healthy Volunteers
Status: RECRUITING
Conditions: HIV-1-infection
Interventions: DRUG: BIKTARVY 50Mg-200Mg-25Mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Nanohydroxyapetite Paste on Reducing Dentin Hypersensitivity
Status: COMPLETED
Conditions: Dentin Hypersensitivity
Interventions: DRUG: 5% Sodium Fluoride Varnish|DRUG: 15% Nanohydroxyapetite paste|DRUG: Glycerol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Three-dimensional Versus Two-dimensional Sacral Colpopexy and Paravaginal Repair
Status: COMPLETED
Conditions: Pelvic Organ Prolapse|Cystocele
Interventions: DEVICE: 3D mode of the 3D Laparoscopic Video System|DEVICE: 2D mode of the 3D Laparoscopic Video System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Optical Coherence Tomography for Drug Eluting Stent Safety
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: sirolimus drug eluting coronary stent Cypher™ (Cordis Corp, Johnson & Johnson Co)|DEVICE: paclitaxel polymer drug eluting stent Taxus Libertè™ (Boston Scientific, Natick MS)|DEVICE: zotarolimus drug eluting coronary stent Endeavor™ (Medtronic, Santa Rosa, CA)|DEVICE: Libertè bare metal coronary stent Libertè™ BMS(Boston Scientific, Natick, MS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Specific Bile Microorganisms Caused Intra-abdominal Abscess on Pancreaticoduodenectomy Patients: Customized Antibiotics And Antifungal Medication May Be Necessary
Status: COMPLETED
Conditions: Intraabdominal Abscess After Procedure
Interventions: OTHER: Pancreaticoduodenectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of the Percutaneous Transvenous Mitral Annuloplasty Device to Reduce Mitral Regurgitation
Status: COMPLETED
Conditions: Heart Failure|Mitral Regurgitation
Interventions: DEVICE: PTMA (Percutaneous Transvenous Mitral Annuloplasty) Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety of Primaquine in Combination With Dihydroartemisinin-piperaquine in G6PD Deficient Males in The Gambia
Status: TERMINATED
Conditions: Malaria
Interventions: DRUG: Dihydroartemisinin-piperaquine (DHAP) administered to G6PD deficient|DRUG: Dihydroartemisinin-piperaquine (DHAP) + 0.25 mg/kg primaquine administered to G6PD deficient|DRUG: Dihydroartemisinin-piperaquine (DHAP) + 0.4 mg/kg primaquine administered to G6PD deficient|DRUG: Dihydroartemisinin-piperaquine (DHAP) + 0.25 mg/kg primaquine administered to G6PD normal|DRUG: Dihydroartemisinin-piperaquine (DHAP) + 0.4 mg/kg primaquine administered to G6PD normal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Effects of Manipulation Versus Stretching on Upper Trapezius Pressure Pain Thresholds
Status: COMPLETED
Conditions: Neurophysiological Mechanisms Manipulation
Interventions: PROCEDURE: CT Manipulation|PROCEDURE: Upper trapezius stretch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Low Temperature Rota-flush Solution in Patients With Severe Calcified Lesion (LOTA-II)
Status: COMPLETED
Conditions: Myocardial Injury
Interventions: OTHER: low temperature rota-flush solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Dose of Esketamine Inhibiting Response to Laryngeal Mask Airway Insertion
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Esketamine 0.2mg/kg|DRUG: Esketamine 0.3mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Creatine as a Treatment Option for Depression in Methamphetamine Using Females
Status: COMPLETED
Conditions: Depression|Substance Abuse|Substance Use|Neuroimaging|Dual Diagnosis
Interventions: DRUG: Creatine monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Healthy Food Prescription Incentive Program
Status: ACTIVE_NOT_RECRUITING
Conditions: Diet, Healthy|Diabetes Mellitus, Type 2|Diabetes Complications
Interventions: BEHAVIORAL: Healthy food incentive|BEHAVIORAL: Healthy food prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy and Safety of SeQuent® Please in the Treatment of Small Vessel Disease (SVD) Patient
Status: UNKNOWN
Conditions: Small Vessel Disease
Interventions: DEVICE: Paclitaxel-eluting PTCA-Balloon Catheter(SeQuent® Please)|DEVICE: rapid exchange PTCA -Balloon Catheter (SeQuent® Neo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ranibizumab Injection in Subjects With Clinically Significant Macular Edema (ME) With Center Involvement Secondary to Diabetes Mellitus (RISE)
Status: COMPLETED
Conditions: Diabetes Mellitus|Macular Edema
Interventions: DRUG: Ranibizumab|DRUG: Sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Telepractice by Smartphone App Technology in Preventing Voice Problems
Status: COMPLETED
Conditions: Prevention of Voice Disorders in Student Teachers
Interventions: BEHAVIORAL: Telepractice Global Voice Prevention Model|BEHAVIORAL: In-person Global Voice Prevention Model|BEHAVIORAL: Telepractice, Vocal Hygiene and Vocal Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ultrasound Guided Quadratus Lumborum Block for Postoperative Pain in Abdominoplasty
Status: COMPLETED
Conditions: Pain
Interventions: PROCEDURE: QLB bloc|DRUG: 0.2% Ropivacaine|DRUG: 0.9% normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy of HAIC, Sintilimab and Bevacizumab for Advanced Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: HAIC|DRUG: Sintilimab|DRUG: Bevacizumab Biosimilar IBI305
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Therapy In Epilepsy Treatment (DIET-Trial): A Randomised Non Inferiority Trial Comparing KD, MAD & LGIT for Drug Resistant Epilepsy
Status: UNKNOWN
Conditions: Drug Resistant Epilepsy
Interventions: OTHER: Ketogenic Diet|OTHER: MAD|OTHER: LGIT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Saving Residual Renal Function Among Haemodialysis Patients Receiving Irbesartan
Status: COMPLETED
Conditions: Kidney Failure, Chronic
Interventions: DRUG: Irbesartan|DRUG: Placebo matching irbesartan 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Adult B Lymphoblastic Lymphoma|Ann Arbor Stage I B Lymphoblastic Lymphoma|Ann Arbor Stage II B Lymphoblastic Lymphoma|Childhood B Acute Lymphoblastic Leukemia|Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|Childhood B Lymphoblastic Lymphoma|Down Syndrome|Hypodiploid B Acute Lymphoblastic Leukemia|Philadelphia Chromosome Positive
Interventions: DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Dexamethasone|DRUG: Doxorubicin Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Leucovorin Calcium|DRUG: Mercaptopurine|DRUG: Methotrexate|DRUG: Pegaspargase|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: Thioguanine|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transplantation of NiCord®, Umbilical Cord Blood-derived Ex Vivo Expanded Cells, in Patients With HM
Status: COMPLETED
Conditions: Hematological Malignancies|Acute Lymphoblastic Leukemia (ALL)|Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome (MDS)
Interventions: DRUG: NiCord®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of Secukinumab 300 mg in Patients With Thyroid Eye Disease (TED)
Status: TERMINATED
Conditions: Thyroid Eye Disease|Graves Orbitopathy
Interventions: DRUG: Secukinumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Curative Effect and Security of Interferon Combined Resveratrol on HBeAg Positive Chronic Hepatitis B Patients
Status: COMPLETED
Conditions: Hepatitis B|Interferon
Interventions: DRUG: Interferon|DRUG: Interferon+resveratrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Positions on the Diffusion and Blockade Effect of Ultrasound-guided Erector Spinae Plane Block
Status: RECRUITING
Conditions: Erector Spinea Plane Block
Interventions: OTHER: Alteration of patients' position after erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Radical Versus Simple Hysterectomy and Pelvic Node Dissection With Low-risk Early Stage Cervical Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Cancer
Interventions: PROCEDURE: Radical Hysterectomy + pelvic lymph node dissection|PROCEDURE: Simple hysterectomy + pelvic lymph node dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection of Lipoarabinomannan in Urine Evaluation of the STANDARDTMF TBLAMFIA and Its Impact on the Initial TB Diagnosis
Status: NOT_YET_RECRUITING
Conditions: Tuberculosis|Diagnoses Disease
Interventions: DEVICE: STANDARDTM F TB LAM FIA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Steroid Injection Which is Added to Percutaneous Trigger Finger Release: a Double-blinded Randomized Controlled Trial.
Status: COMPLETED
Conditions: Trigger Finger
Interventions: PROCEDURE: Steroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Amphotericin B for the Treatment of Cryptococcal Meningitis
Status: UNKNOWN
Conditions: Cryptococcal Meningitis
Interventions: DRUG: Liposomal amphotericin B|DRUG: Amphotericin B-deoxycholate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial Evaluating WNT974 in Patients With Metastatic Head and Neck Squamous Cell Carcinoma
Status: WITHDRAWN
Conditions: Squamous Cell Carcinoma, Head And Neck
Interventions: DRUG: WNT974
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melatonin and Response to Lithium
Status: RECRUITING
Conditions: Bipolar Disorder I
Interventions: DIAGNOSTIC_TEST: urine collection|DIAGNOSTIC_TEST: Level of Proteins|DIAGNOSTIC_TEST: Level of mRNA and miRNA|DIAGNOSTIC_TEST: Level of plasmatic and intraerythrocytic lithium
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevention of Benzodiazepine Misuse in Primary Care
Status: WITHDRAWN
Conditions: Benzodiazepine Dependence|Benzodiazepine Abuse|Substance Use Disorders
Interventions: BEHAVIORAL: Educational intervention with prescription feedback|BEHAVIORAL: Information on treatment guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Audiovisual Videodisc Education and Modification of Expectations With Total Knee Replacement (TKR)
Status: COMPLETED
Conditions: Total Knee Replacement
Interventions: BEHAVIORAL: Educational audiovisual videodisc and medical verbal information|BEHAVIORAL: Medical verbal information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of Combination Therapy With CHOP-Zenapax (CHOP-daclizumab)
Status: COMPLETED
Conditions: HTLV-I Associated Adult T-cell Leukaemia/Lymphoma (ATLL)
Interventions: DRUG: CHOP-daclizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparison of INIT and Dry Needling on Trigger Points in Knee OA
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: OTHER: Integrated Neuromuscular Inhibition Technique:|OTHER: Dry needling:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Rituximab, Chemotherapy, and Filgrastim in Treating Patients With Burkitt's Lymphoma or Burkitt's Leukemia
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: leucovorin calcium|DRUG: methotrexate|DRUG: prednisone|DRUG: vincristine sulfate|DRUG: Allopurinol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents
Status: COMPLETED
Conditions: Acute Lymphoid Leukemia
Interventions: DRUG: PEG-rhG-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Methods for Bowel Preparation in Patients With Constipation
Status: UNKNOWN
Conditions: Health Behavior
Interventions: DRUG: Split dose of 4L PEG|DRUG: Three times dose of 4L PEG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined 18F-NaF/18F-FDG PET/MRI for Detection of Skeletal Metastases
Status: COMPLETED
Conditions: Cancer
Interventions: PROCEDURE: Bone scan|DRUG: 99mTc-methyl diphosphonate|PROCEDURE: Positron Emission Tomography (PET) scan|DRUG: 18F-Fludeoxyglucose (18F-FDG)|PROCEDURE: Computed Tomography (CT) scan|DRUG: 18F-Sodium Fluoride (18F-NaF)|PROCEDURE: Whole Body Magnetic Resonance Imaging (WB-MRI) scan|DRUG: Gadopentetate dimeglumine|DRUG: Gadofosveset|DRUG: Gadobutrol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Extracorporeal Flow Abolition in Relation With Primary Insufficiency of Great Saphenous Veins (GSV) Using High Intensity Focused Ultrasound (HIFU) Generated by Sonovein: A Multi Center Prospective Pivotal Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Venous Insufficiency
Interventions: DEVICE: Sonovein Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alcohol and Breast Cancer (ABC) Trial
Status: COMPLETED
Conditions: ER+ Breast Cancer|Breast Cancer|Aromatase Inhibitors
Interventions: OTHER: White Wine|OTHER: Grape Juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PrEP My Way: A Hybrid Type 1 Clinical Effectiveness-implementation Trial to Promote PrEP Persistence Among Young Kenyan Women
Status: NOT_YET_RECRUITING
Conditions: HIV/AIDS
Interventions: BEHAVIORAL: PrEP My Way intervention|BEHAVIORAL: PrEP My Way intervention without STI testing|BEHAVIORAL: Enhanced standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: RI Study to Assess and Compare the Pharmacokinetic Parameters of MD1003 in Renal Impaired Patients and Healthy Subjects
Status: TERMINATED
Conditions: Healthy Volunteers|Impaired Renal Function
Interventions: DRUG: MD1003
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pilot Mammography Reader Study to Assess Breast Cancer Detection in FFDM Plus DBT Versus FFDM Alone
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DEVICE: FFDM Plus DBT|DEVICE: FFDM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of the Efficacy and Safety of Topiramate in the Treatment of Patients With Difficult to Control Epilepsy
Status: COMPLETED
Conditions: Epilepsy|Epilepsies, Partial|Seizures
Interventions: DRUG: topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Pulsed Radiofrequency of S2-4 Versus Ganglion Impar Neurolysis for Severe Perianal and Perineal Pain in Cancer Patients
Status: COMPLETED
Conditions: Analgesia
Interventions: PROCEDURE: Ganglion Impar Neurolysis|PROCEDURE: Bilateral S2, S3 and S4 Pulsed radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of the 2005-2006 Fluzone® Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluzone®: Influenza Virus Vaccine|BIOLOGICAL: Fluzone®: Influenza Virus Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Duration of Urinary Catheter Treatment After Cesarean Delivery Under Spinal Anesthesia
Status: ENROLLING_BY_INVITATION
Conditions: Urinary Retention|Cesarean Section Complications
Interventions: DEVICE: Urinary catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduction of Dentine Hypersensitivity After Use of Different Dentifrices
Status: RECRUITING
Conditions: Sensitivity, Tooth
Interventions: DRUG: 5% CALCIUM SODIUM PHOSPHOSILICATE|DRUG: 8% Arginine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cilostazol 100 mg Tablet Formulations Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cilostazol 100 mg tablets|DRUG: Pletal® 100 mg tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neoadjuvant mFOLFOXIRI Chemotherapy Alone for Extramural Vascular Invasion Positive Locally Advanced Rectal Cancer
Status: UNKNOWN
Conditions: Locally Advanced Rectal Cancer
Interventions: DRUG: mFOLFOXIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Aripiprazole Versus Placebo in the Reduction of Aggressive and Aberrant Behavior in Autistic Children
Status: COMPLETED
Conditions: Autism
Interventions: DRUG: Aripiprazole|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HerpeVac Trial for Young Women
Status: COMPLETED
Conditions: Herpes Simplex Infection
Interventions: BIOLOGICAL: HSV vaccine or SB208141, GSK Biologicals' glycoprotein D (gD)-Alum/3-deacylated form of Monophosphoryl Lipid A (MPL) candidate genital herpes vaccine|BIOLOGICAL: Havrix™, GlaxoSmithKline (GSK) Biologicals' licensed Hepatitis A vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Two New Innovative Haemostasis Tests: Measurement of the Active Form of GTP-bound Rap1b (aRap1b) in Platelets and the Pro and Antithrombotic Balance of Circulating Endothelial Microvesicles (patEMV) (INNOV-CKD Test)
Status: RECRUITING
Conditions: Chronic Renal Failure
Interventions: BIOLOGICAL: BLOOD SAMPLES
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Custom Needle Preparation for Suprachoroidal Steroid Injection (One Year Results)
Status: UNKNOWN
Conditions: Diabetic Macular Edema|Vogt Koyanagi Harada Disease|Retinal Vein Occlusion
Interventions: DRUG: Suprachoroidal triamcinolone acetonide injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Dose-Finding Study of KWA-0711 in Patients With Chronic Constipation (CC)
Status: COMPLETED
Conditions: Chronic Constipation
Interventions: DRUG: KWA-0711|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Azeliragon in Patients With Mild Alzheimer's Disease and Impaired Glucose Tolerance
Status: TERMINATED
Conditions: Alzheimer Disease
Interventions: DRUG: Azeliragon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia, Pediatric
Interventions: DRUG: Pegaspargase|DRUG: Erwinia asparaginase|DRUG: Cyclophosphamide|DRUG: CYTARABINE|DRUG: DASATINIB|DRUG: DEXAMETHASONE|DRUG: Dexrazoxane|DRUG: Doxorubicin|DRUG: ETOPOSIDE|DRUG: HYDROCORTISONE|DRUG: LEUCOVORIN CALCIUM|DRUG: MERCAPTOPURINE|DRUG: METHOTREXATE|DRUG: NELARABINE|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remission Evaluation of a Metabolic Intervention in Type 2 Diabetes With Forxiga
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: insulin glargine|DRUG: metformin|DRUG: Forxiga|BEHAVIORAL: Lifestyle therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study Comparing Clopidogrel/Aspirin Combination Tablet With Coadministration of Clopidogrel and Aspirin
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HCP0911 / clopidogrel, aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Plerixafor Plus G-CSF in Mobilizing Stem Cells for Autologous Peripheral Blood Transplantation
Status: UNKNOWN
Conditions: Lymphoma, Non-Hodgkin|Lymphoma, Hodgkin|Myeloma|Stem Cell Transplant Complications
Interventions: DRUG: Plerixafor 0.12 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Placental Alpha Microglobulin-1(PAMG-1) to Diagnose Premature Rupture of Membranes in Pregnant Women
Status: TERMINATED
Conditions: Preterm Labor|Preterm Birth
Interventions: DEVICE: PAMG-1 immunoassay
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Pharmacokinetic Profiles of BIIB017 (Peginterferon Beta-1a) and Rebif® (Interferon Beta-1a) in Healthy Volunteers
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: peginterferon beta-1a|DRUG: Rebif
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Evaluation of the Strattice-LIFT to Treat Anal Fistula
Status: TERMINATED
Conditions: Anal Fistula|Rectal Fistula|Fistula in Ano|Transsphincteric Fistula
Interventions: DEVICE: Strattice-LIFT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of Macitentan in Patients With Idiopathic Pulmonary Fibrosis
Status: WITHDRAWN
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Macitentan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Nintendo Switch on Rehabilitation Programs for Elderly People With Cognitive Impairment
Status: COMPLETED
Conditions: Cognitive Impairment|Elderly People|Healthy Aging|Occupational Therapy
Interventions: PROCEDURE: Conventional occupational therapy sessions.|PROCEDURE: Conventional occupational therapy sessions + Nintendo Switch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT