pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: D-cycloserine and Treatment of Feeding Disorders
Status: COMPLETED
Conditions: Feeding Disorders|Specific Phobia
Interventions: BEHAVIORAL: Behavioral Intervention|DRUG: d-cycloserine (DCS)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Respiratory Training in Individuals With Ankylosing Spondylitis
Status: RECRUITING
Conditions: Ankylosing Spondylitis|Exercise Training|Diaphragm|Mobility
Interventions: BEHAVIORAL: Expanded diaphragm exercise|BEHAVIORAL: Standard diaphragm exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: 18F FES-PET/MRI for Tailoring Treatment of Luminal A and Lobular Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer Female|Lobular Breast Carcinoma|PET/MRI|Axillary Lymphadenopathy|Luminal A Breast Cancer
Interventions: DRUG: FES|PROCEDURE: PET/MRI A|PROCEDURE: PET/MRI B|PROCEDURE: PET/MRI C|PROCEDURE: PET/MRI D|GENETIC: Translational analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Metoprolol on Anaesthesia, the Need for Analgesics, and Pain in Breast Cancer Patients
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: Metoprolol|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
Status: RECRUITING
Conditions: Advanced Non-Small Cell Lung Cancer|Metastatic Non-Small Cell Lung Cancer
Interventions: DRUG: Adagrasib|DRUG: Adagrasib|DRUG: Adagrasib|DRUG: Adagrasib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantitative Assessment of the Efficacy of Sweeps Laser Activation Systems
Status: COMPLETED
Conditions: Periapical Periodontitis|Polymerase Chain Reaction|Enterococcus Faecalis Infection
Interventions: OTHER: sweeps laser to use irrigation activation|OTHER: PUI to use irrigation activation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study of TP-05 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: TP-05 (lotilaner oral capsules)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pilot Study of Expanded, Donor Natural Killer Cell Infusions for Refractory Non-B Lineage Hematologic Malignancies and Solid Tumors
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute|Leukemia, Lymphocytic, Acute, T-Cell|Juvenile Myelomonocytic Leukemia Lymphoblastic|T-cell Lymphoblastic Lymphoma|Myelodysplastic Syndrome
Interventions: PROCEDURE: Haploidentical donor derived natural killer cell infusion|DRUG: Chemotherapy|DEVICE: CliniMACS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kinesiotaping in Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Kinesiotape|DEVICE: Sham-kinesiotape|OTHER: Home-based exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Buspar on Depressive Symptom Improvement and Neuroprotection in Patients With Anxiety Disorder
Status: WITHDRAWN
Conditions: Anxiety Disorder
Interventions: DRUG: buspirone+alprazolam|DRUG: alprazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Amniotic Membrane and Platelet Rich Plasma Clot for Management of Central Corneal Perforation
Status: COMPLETED
Conditions: Corneal Perforation
Interventions: PROCEDURE: Platelet rich plasma clot implantation|PROCEDURE: Wound closure with amniotic membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability and Efficacy Study of NC525 in Subjects With Advanced Myeloid Neoplasms
Status: RECRUITING
Conditions: Relapsed or Refractory Acute Myeloid Leukemia|Relapsed or Refractory Chronic Myelomonocytic Leukemia|Relapsed or Refractory Myelodysplastic Syndrome
Interventions: DRUG: NC525
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PD-1 Antibody + XELOX in 1st Line Serum A-fetoprotein (AFP)-Elevated Gastric or Gastroesophageal Junction Adenocarcinoma
Status: UNKNOWN
Conditions: Gastric or Gastroesophageal Junction Adenocarcinoma|AFP
Interventions: DRUG: Anti-PD-1 antibody|DRUG: XELOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Manipulative Therapy Techniques to Treat Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain|Chronic Disease
Interventions: OTHER: Manipulative Therapy Techniques|OTHER: Functional Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Invasive Ventilation for Neonates With Acute Respiratory Distress Syndrome(ARDS)
Status: WITHDRAWN
Conditions: Acute Respiratory Distress Syndrome|Conventional Mechanical Ventilation|High Frequency Oscillation Ventilation
Interventions: DEVICE: HFOV|DEVICE: CMV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: carmustine|DRUG: chemotherapy|DRUG: cisplatin|DRUG: etoposide|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Overcoming Endocrine Resistance in Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Fulvestrant|DRUG: Lapatinib|DRUG: Aromatase Inhibitors|DRUG: Placebo Lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Capmatinib in Indian Patients With MET Exon 14 Skipping Mutation Positive Advanced NSCLC.
Status: RECRUITING
Conditions: Non-Small Cell Lung Carcinoma
Interventions: DRUG: Capmatinib 150 mg|DRUG: Capmatinib 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Short Term Ovarian Suppression on Androgen Overproduction in Overweight Girls With Androgen Excess
Status: WITHDRAWN
Conditions: Hyperandrogenemia|Obesity|Polycystic Ovary Syndrome
Interventions: DRUG: Leuprolide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PET Imaging of Endotoxin-induced iNOS Activation
Status: COMPLETED
Conditions: Pneumonia
Interventions: DRUG: Endotoxin (E. coli O:113, Reference Endotoxin)|DRUG: [18F](+/-)NOS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of a Self-guided Mobile Application in Improving Wellbeing and Stress Coping
Status: COMPLETED
Conditions: Stress
Interventions: DEVICE: Self-guided program on stress coping|DEVICE: Self-guided program on cooperation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fenofibrate in Combination With Ursodeoxycholic Acid (UDCA) in Primary Biliary Cirrhosis
Status: WITHDRAWN
Conditions: Primary Biliary Cirrhosis
Interventions: DRUG: fenofibrate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability Comparison of Differin® Cream 0.1% Versus Differin® Lotion 0.1% in Subjects With Healthy Skin
Status: COMPLETED
Conditions: Skin Manifestations
Interventions: DRUG: adapalene cream 0.1% and adapalene lotion 0.1%|DRUG: adapalene lotion 0.1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Hepatitis c micrOelimination Program in Non imprisonEd SenTenced With Alternative Measures
Status: UNKNOWN
Conditions: Hepatotropic Virus Infection|Addictive Behaviours o Conducts|Mental Disease|People Sentenced to Non-custodial Sentences
Interventions: OTHER: Observational study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cyclophotocoagulation in Primary Open Angle Glaucoma
Status: UNKNOWN
Conditions: Primary Open Angle Glaucoma
Interventions: PROCEDURE: Cyclophotocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy of Rotigotine on Parkinson's Disease-Associated Pain
Status: COMPLETED
Conditions: Advanced Idiopathic Parkinson's Disease
Interventions: DRUG: Rotigotine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-inflammatory Effects of Enriched Enteral Nutrition During Human Experimental Endotoxemia
Status: COMPLETED
Conditions: Endotoxemia
Interventions: OTHER: control enteral nutrition|OTHER: enriched enteral feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Of SB-751689, Atorvastatin, Ketoconazole, And Rosuvastatin In Health Postmenopausal Women.
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: SB-751689
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Camrelizumab in Combination With Nab-paclitaxel and Famitinib as a First Line Treatment in Patients With Unresectable Locally Advanced or Metastatic Immunomodulatory Triple Negative Breast Cancer(FUTURE-C-PLUS)
Status: UNKNOWN
Conditions: Triple-Negative Breast Cancer
Interventions: DRUG: camrelizumab in combination with nab-paclitaxel and famitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Randomized, Double-blind Non-inferiority Trial to Evaluate the Efficacy and Safety of Entelon®
Status: COMPLETED
Conditions: Diabetic Retinopathy
Interventions: DRUG: Vitis vinifera extract|DRUG: Calcium Dobesilate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Culturally Adapted iCBT for Arabic-speaking Refugee and Migrant Youth With Common Mental Health Problems
Status: RECRUITING
Conditions: Depressive Symptoms|Anxiety|Insomnia|Grief|Psychological Trauma|Resilience|Stress|Marital Relationship|Psychological Well-Being
Interventions: BEHAVIORAL: Culturally Adapted iCBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Patient Tolerance, Pharmacodynamics and Pharmacokinetics of Lanthanum Polystyrene Sulfonate Powder
Status: UNKNOWN
Conditions: Hyperphosphatemia
Interventions: DRUG: Lanthanum Polystyrene Sulphonate Powder|DRUG: Lanthanum Carbonate 500 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Tocilizumab for the Treatment of Acute AION Related to GCA
Status: UNKNOWN
Conditions: Giant Cell Arteritis|Optic Ischaemic Neuropathy
Interventions: DRUG: tocilizumab and IV steroids combination|OTHER: IV steroids combination alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Skin Wrinkle Test: a Simple Clinical Test of Regional Block Success
Status: COMPLETED
Conditions: Skin Manifestations
Interventions: DIAGNOSTIC_TEST: Stimulated skin wrinkling test|PROCEDURE: Digital Nerve Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Siplizumab for Sickle Cell Disease Transplant
Status: RECRUITING
Conditions: Anemia, Sickle Cell
Interventions: DRUG: Siplizumab|PROCEDURE: Exchange Transfusion|PROCEDURE: Total Body Irradiation|PROCEDURE: Stem Cell Infusion|DRUG: Cyclophosphamide 50mg|DRUG: Mesna|DRUG: Sirolimus Oral Tablet|DRUG: Rituximab or Biosimilar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY2409021 Formulations and the Effect of Food
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: LY2409021 Reference Form|DRUG: LY2409021 Test-Med Formulation (medium particle size)|DRUG: LY2409021 Test-High Formulation (high particle size)|DRUG: LY2409021 Test-Low Formulation (low particle size)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of Probiotics in Oral Health of Patients With Dental Implants
Status: COMPLETED
Conditions: Mucositis
Interventions: DIETARY_SUPPLEMENT: Probiotic tablets of Lactobacillus reuteri|DIETARY_SUPPLEMENT: Placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Asenapine Compared With Olanzapine in Patients With Persistent Negative Symptoms of Schizophrenia (A7501013)(COMPLETED)(P05771)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Asenapine|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects and Predictors of Patella Taping in the Treatment of Patellafemoral Pain Syndrome
Status: COMPLETED
Conditions: Patellofemoral Pain Syndrome
Interventions: OTHER: taping
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Pulsatile Intravenous FSH to Mitigate Reprometabolic Syndrome
Status: NOT_YET_RECRUITING
Conditions: Infertility|Obesity
Interventions: DRUG: Follicle Stimulating Hormone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Modulating ApoE Signalling to Reduce Brain Inflammation, deLirium and postopErative Cognitive Dysfunction
Status: COMPLETED
Conditions: Postoperative Delirium|Postoperative Cognitive Dysfunction
Interventions: DRUG: CN-105|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ENgaging in Advance Care Planning Talks Group Visit Intervention for Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Advance Care Planning Group Visits
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Antibody DS-8273a Administered in Combination With Nivolumab in Subjects With Advanced Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Neoplasm
Interventions: DRUG: DS-8273a + nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study On The Effect Of GW876008 On Cerebral Blood Flow In Irritable Bowel Syndrome (IBS) Patients And Healthy Volunteers
Status: COMPLETED
Conditions: Irritable Colon|Irritable Bowel Syndrome (IBS)
Interventions: DRUG: GW876008 200mcg|DRUG: GW876008 20mcg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Bioactive Restorative vs. RMGI in Class V: A Randomized Control Trial
Status: UNKNOWN
Conditions: Dental Restoration Failure
Interventions: OTHER: Bioactive Restorative Material|OTHER: Resin-modified glass ionomer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability of Oral Eletriptan for Treatment of Acute Migraine
Status: COMPLETED
Conditions: Migraine With or Without Aura
Interventions: DRUG: Placebo|DRUG: Eletriptan 20 mg|DRUG: Eletriptan 40 mg|DRUG: Eletriptan 80 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib, Open-label, Multicenter Study of the Safety and PK of the Combination of rhuMAb2c4 (Omnitarg), a Recombinant Humanized Antibody to HER2, and Capecitabine (Xeloda) in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: Capecitabine|DRUG: RhuMab 2C4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anatomy-based Resection or Margin-based Resection for Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma by BCLC Stage
Interventions: PROCEDURE: anatomical liver resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Exploring the Use of Vaccine and Antigen Challenges for Immune Monitoring in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Imvanex|BIOLOGICAL: Shingrix|BIOLOGICAL: LPS|BIOLOGICAL: Candin|OTHER: Skin Biopsy|OTHER: Saline Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Compaction Femur Preparation for Cementless Total Hip Arthroplasty (THA) Unilateral
Status: UNKNOWN
Conditions: Coxarthrosis
Interventions: PROCEDURE: Bone preparation technique: compaction|PROCEDURE: Bone preparation technique: conventional technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LifePearl Anthracyclin Registry in Selective Chemo-Embolization of Patients With Unresectable HCC (PARIS Registry)
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DEVICE: DEB-TACE using anthracyclin loaded LifePearl™
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of the Effect of a Novel Starch (Glycosade) Versus Gastrostomy Tube-Dextrose Infusion on Overnight Euglycaemia Control in Children With Glycogen Storage Disease Type I: Open Label Demonstration Trial
Status: COMPLETED
Conditions: Glycogen Storage Disorder Type 1|Hypoglycemia|Cornstarch|Glycosade
Interventions: DIETARY_SUPPLEMENT: Glycosade
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Trial to Evaluate the Efficacy and Safety of Initial Combination Therapy With Gemigliptin 50mg q.d and Metformin q.d
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Gemigliptin 50mg|DRUG: Placebo(Metformin)|DRUG: Metformin|DRUG: Placebo(Gemigliptin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Infection in Indian Neonates - Phase II Probiotics Study
Status: COMPLETED
Conditions: Sepsis
Interventions: DIETARY_SUPPLEMENT: Probiotic supplementation (Lactobacillus plantarum)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Pain of Conventional to Buffered Local Anesthesia During Injection in Pediatric Dental Patients
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Sodium bicarbonate|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Influence of a Delivery System on the Efficacy of a Probiotic Intervention
Status: COMPLETED
Conditions: Delayed Transit Time|Irregular Bowel Function
Interventions: DIETARY_SUPPLEMENT: Yogurt smoothie without probiotic|DIETARY_SUPPLEMENT: Yogurt smoothie with probiotic added post fermentation|DIETARY_SUPPLEMENT: Yogurt smoothie with probiotic added pre-fermentation|DIETARY_SUPPLEMENT: A capsule containing the probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Connective Tissue Massage in Patients With Fibromyalgia
Status: RECRUITING
Conditions: Fibromyalgia
Interventions: OTHER: Connective tissue massage|OTHER: Self myofascial relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Controlled Trial of Ganaxolone in Patients With Infantile Spasms
Status: COMPLETED
Conditions: Infantile Spasms
Interventions: DRUG: Ganaxolone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of β-tricalcium Phosphate/Calcium Sulfate Versus Allografts
Status: COMPLETED
Conditions: Tooth Extraction
Interventions: OTHER: Alloplast bone grafting material (EthOss, Ethoss Regeneration Ltd, Silsden, UK).|OTHER: Allograft bone grafting material.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screening TO Prevent ColoRectal Cancer (STOP CRC) Among At-Risk Chinese and Korean American Primary Care Patients
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BEHAVIORAL: Advanced Control|BEHAVIORAL: Culturally-Adapted Decision Support Navigation Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Radiofrequency (RF) Ablation for Atrial Fibrillation (AF) in Patients With Heart Failure With Preserved Ejection Fraction
Status: TERMINATED
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: PROCEDURE: RF ablation of AF using CARTO 3 and a Thermocool ST SF ablation catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing V.A.C. Negative Pressure Wound Therapy (NPWT) to Moist Wound Therapy (MWT) in the Treatment of Diabetic Foot Amputation Wounds
Status: TERMINATED
Conditions: Diabetic Amputation Foot Wound
Interventions: DEVICE: V.A.C. Therapy|DEVICE: Moist wound therapy (MWT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S9912 Combination Chemo in Stage III Ovarian Cancer,
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Peritoneal Cavity Cancer
Interventions: DRUG: cisplatin|DRUG: liposomal doxorubicin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Comparison of Suture Removal Time for Simple Surgical Defects of the Head and Neck
Status: COMPLETED
Conditions: Cutaneous Tumors
Interventions: PROCEDURE: Suture removal time 7 days|PROCEDURE: Suture removal time14 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chlorhexidine Scrub, ZnO Nanoparticles Socks and the Combination for Treatment of Pitted Keratolysis
Status: COMPLETED
Conditions: Foot Dermatoses
Interventions: DRUG: Chorhexidine scrub|DEVICE: ZnO-NPs socks|COMBINATION_PRODUCT: Combination of chorhexidine scrub and ZnO-NPs socks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Free Samples for Health
Status: ENROLLING_BY_INVITATION
Conditions: Cigarette Smoking
Interventions: BEHAVIORAL: Ask-Advise-Refer|DRUG: Nicotine Patch, 14 Mg/24 Hr Transdermal Film, Extended Release|DRUG: Nicotine lozenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Normative Data for Static and Dynamic Posturography (NeuroCom EQUITEST and BALANCE MASTER) in Subjects Older Than 79yrs
Status: COMPLETED
Conditions: Equilibrium; Disorder, Labyrinth|Aging
Interventions: DIAGNOSTIC_TEST: instrumental description of the subject's center of gravity (COG) sway
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis
Status: COMPLETED
Conditions: Localized Aggressive Periodontitis
Interventions: DRUG: β-1,3/1,6-D-glucan|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on Targeted CD19CAR-T Therapy for Autoimmune Diseases
Status: NOT_YET_RECRUITING
Conditions: Systemic Lupus Erythematosus|Systemic Sclerosis|ANCA Associated Vasculitis|Idiopathic Inflammatory Myopathies|Sjogren's Syndrome|Autoimmune Diseases
Interventions: DRUG: RD06-04 CART Cell Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ-75348780 in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma, Non-Hodgkin|Leukemia, Lymphocytic, Chronic, B-Cell
Interventions: DRUG: JNJ-75348780
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MumCare: Mum's Cardiovascular Health for Life
Status: ENROLLING_BY_INVITATION
Conditions: Hypertensive Disorder of Pregnancy|Preeclampsia|Gestational Hypertension|Gestational Diabetes
Interventions: DEVICE: Access to MumCare app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Safety and Immunogenicity Trial With an Adjuvanted Tuberculosis (TB) Subunit Vaccine in Purified Protein Derivative (PPD) Positive Volunteers
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: 50 microg. antigen + adjuvant (500 nmol KLK + 20 nmol ODN1a)|BIOLOGICAL: 50 microg. antigen + adjuvant (500 nmol KLK + 20 nmol ODN1a)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: TCHCCT-Zhong-Xing-Emergency-Department-airway-clincal (TTC)
Status: UNKNOWN
Conditions: Intubation;Difficult|Intubation Complication
Interventions: PROCEDURE: stylet-assisted epiglottic lifting|DEVICE: bougie-assisted intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Comparison Angioplasty Outcomes at Hospitals With and Without On-site Cardiac Surgery
Status: COMPLETED
Conditions: Coronary Arteriosclerosis|Angina Pectoris
Interventions: OTHER: Percutaneous coronary intervention (PCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors
Status: COMPLETED
Conditions: Childhood Germ Cell Tumor|Extragonadal Germ Cell Tumor|Testicular Germ Cell Tumor
Interventions: BIOLOGICAL: bleomycin sulfate|BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: etoposide|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: conventional surgery|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Using a General Health Promotion Approach to Help Smokers With Chronic Diseases Quit
Status: UNKNOWN
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: General Health Promotion Approach|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Symptom-Adapted Physical Activity Intervention in Minimizing Physical Function Decline in Older Patients With Acute Myeloid Leukemia Undergoing Chemotherapy
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Recurrent Adult Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: PROCEDURE: quality-of-life assessment|OTHER: counseling intervention|BEHAVIORAL: exercise intervention|OTHER: educational intervention|PROCEDURE: standard follow-up care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioequivalence of Metronidazole Gel, 0.75% in the Treatment of Bacterial Vaginosis
Status: COMPLETED
Conditions: Bacterial Vaginosis
Interventions: DRUG: Metronidazole|DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: OTHER
Clinical trial: Impact of Web and Smartphone-based Physical Activity Program on Physical Activity Level 12 Months After a Balneotherapy
Status: COMPLETED
Conditions: Physical Activity|Chronic Diseases|Obesity|Diabetes|Rheumatic Diseases|Cardiovascular Diseases|Breast Cancer|Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: Physical activity program after a balneotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Pharmacokinetics and Safety of Dexlansoprazole in Pediatric Subjects With Symptomatic Gastroesophageal Reflux Disease
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: Dexlansoprazole|DRUG: Dexlansoprazole|DRUG: Dexlansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Infusion of Specially Treated Umbilical Cord Stem Cells After Chemoradiation Treatment for Blood Cancers
Status: COMPLETED
Conditions: Acute Lymphocytic Leukemia|Acute Myeloid Leukemia|Myelodysplastic Syndrome|Non-Hodgkin Lymphoma|Chronic Myelogenous Leukemia
Interventions: PROCEDURE: Expansion of umbilical cord stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Repercussions of the Correction (Surgical and Non Surgical) of Pectus Excavatum-type Thoracic Deformities
Status: COMPLETED
Conditions: Pectus Excavatum
Interventions: PROCEDURE: surgical treatment|PROCEDURE: orthopedic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PASO Automated Template Matching for PVC Ablation
Status: UNKNOWN
Conditions: PVC - Premature Ventricular Complex|Cardiomyopathies|Heart Failure|Ventricular Tachycardia
Interventions: PROCEDURE: PASO Pacemapping|PROCEDURE: Conventional Pacemapping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Maternal Determinants of Infant Immunity to Pertussis
Status: RECRUITING
Conditions: Vaccination; Infection|Maternal-Fetal Relations|Pertussis|Immunoglobulins
Interventions: BIOLOGICAL: Triaxis® (Pertussis-containing vaccine)|BIOLOGICAL: Vaxelis® (Pertussis-containing vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Outcomes for Lumbar Decompressions With Use of Liposomal Bupivicaine
Status: RECRUITING
Conditions: Lumbar Spinal Stenosis
Interventions: DRUG: Liposomal bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Recurrent Stroke Prevention Clinical Outcome Study
Status: UNKNOWN
Conditions: Hypertension|Stroke|Blood Pressure
Interventions: DRUG: Losartan, Losartan and HCTZ, Amlodipine , Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: TEAS on Sleep Quality and POCD in Elderly Patients
Status: UNKNOWN
Conditions: Transcutaneous Electrical Acupoint Stimulation|Postoperative Sleep Disturbances|Postoperative Cognitive Dysfunction|Elderly Patients
Interventions: DEVICE: TEAS|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Stimulation in Chronic Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Transcutaneous spinal cord stimulation|OTHER: Activity Based Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 90° Rotation Technique for LMA FlexibleTM Insertion
Status: COMPLETED
Conditions: Laryngeal Masks
Interventions: PROCEDURE: 90° rotational technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Intensive Versus Standard Treatment for Spinal Anesthesia-induced Hypotension on Maternal Hemodynamics
Status: NOT_YET_RECRUITING
Conditions: Outcome
Interventions: DRUG: Alpha-Agonist|DRUG: α-adrenergic receptor agonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Study Generic Estradiol 10 mcg Vaginal Tablets in the Treatment of Vulvar and Vaginal Atrophy in Post Menopausal Women.
Status: COMPLETED
Conditions: Vulvar and Vaginal Atrophy
Interventions: DRUG: Estradiol Vaginal Tablets 10 mcg (Glenmark)|DRUG: Vagifem® (Estradiol Vaginal Tablets) 10 mcg (Novo Nordisk)|DRUG: Placebo of Estradiol Vaginal Tablets 10 mcg (Glenmark)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adherence to Survivorship Care Guidelines in Health Care Providers for Non-Small Cell Lung Cancer and Colorectal Cancer Survivor Care
Status: COMPLETED
Conditions: Adenocarcinoma of the Lung|Mucinous Adenocarcinoma of the Colon|Mucinous Adenocarcinoma of the Rectum|Signet Ring Adenocarcinoma of the Colon|Signet Ring Adenocarcinoma of the Rectum|Squamous Cell Lung Cancer|Stage I Colon Cancer|Stage I Rectal Cancer|Stage IA Non-small Cell Lung Cancer|Stage IB Non-small Cell Lung Cancer|Stage IIA Colon Cancer|Stage IIA Non-small Cell Lung Cancer|Stage IIA Rectal Cancer|Stage IIB Colon Cancer|Stage IIB Non-small Cell Lung Cancer|Stage IIB Rectal Cancer|Stage IIC Colon Cancer|Stage IIC Rectal Cancer|Stage IIIA Colon Cancer|Stage IIIA Non-small Cell Lung Cancer|Stage IIIA Rectal Cancer|Stage IIIB Colon Cancer|Stage IIIB Non-small Cell Lung Cancer|Stage IIIB Rectal Cancer|Stage IIIC Colon Cancer|Stage IIIC Rectal Cancer
Interventions: OTHER: educational intervention|OTHER: medical chart review
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Allogeneic Regenerative Islet Transplantation for the Treatment of Brittle Type 1 Diabetes Mellitus
Status: RECRUITING
Conditions: Brittle Type 1 Diabetes Mellitus
Interventions: PROCEDURE: The method of islet transplantation is through percutaneous transhepatic portal vein puncture.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Soluble Fibre Supplementation in NAFLD
Status: RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease|Non Alcoholic Steatohepatitis|Hepatic Steatosis
Interventions: DIETARY_SUPPLEMENT: Fructo-oligosaccharide enriched inulin supplement|OTHER: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Doxorubicin in Treating Patients With Liver or Bile Duct Cancer
Status: UNKNOWN
Conditions: Extrahepatic Bile Duct Cancer|Gallbladder Cancer|Liver Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: pegylated liposomal doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Different Protocols for Repeated Transarterial Chemoembolization in the Treatment of Patients With Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Liver Cancer
Interventions: PROCEDURE: transarterial chemoembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Toxicity of Bepotastine 1,5% PF vs Olopatadine 0,2% With BAK on Allergic Conjunctivitis Treatment
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: Bepotastine Besilate 1.5% PF|DRUG: Olopatadine Hydrochloride 0.2% BAK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MEDI4736 Combinations in Metastatic Renal Cell Carcinoma
Status: UNKNOWN
Conditions: Renal Clear Cell Carcinoma|Renal Papillary Cell Carcinoma
Interventions: DRUG: Savolitinib|DRUG: MEDI4736|DRUG: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy Study to Compare the Treatment Effects of Rabeprazole and Lansoprazole Depending on the Genotyping of CYP2C19 in Treating Reflux Esophagitis
Status: COMPLETED
Conditions: Reflux Esophagitis
Interventions: DRUG: Rabeprazole|DRUG: Lansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contralaterally Controlled Functional Electrical Stimulation Plus Video Games for Hand Therapy After Stroke
Status: COMPLETED
Conditions: Upper Extremity Hemiplegia|Stroke
Interventions: DEVICE: Contralaterally Controlled Functional Electrical Stimulation (CCFES)|DEVICE: Hand Therapy Video Games
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dynamic Knee Laxity Measurement Coupled to MRI in Cases of Suspected Partial Anterior Cruciate Ligament Tear
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Tear
Interventions: DEVICE: LaxIRM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Randomized Evaluation of Beta Blocker and ACEI/ARB Treatment in MINOCA Patients - MINOCA-BAT
Status: TERMINATED
Conditions: Myocardial Infarction With Non-obstructive Coronary Arteries
Interventions: DRUG: Beta blocker|DRUG: ACEI|DRUG: ARB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real World Evaluation of the Activity and Safety of Fostamatinib in Consecutive Adult Patients With ITP
Status: NOT_YET_RECRUITING
Conditions: ITP - Immune Thrombocytopenia|Chronic ITP|Refractory ITP
Interventions: DRUG: Fostamatinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ibuprofen Supplementation After Resistance Training and Its Effects on Bone in Older Women
Status: COMPLETED
Conditions: Sarcopenia|Osteoporosis
Interventions: DRUG: Non-steroidal anti-inflammatory drug (Ibuprofen)|OTHER: placebo|BEHAVIORAL: Resistance exercise|BEHAVIORAL: Flexibility training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vascular and Cognitive Assessments in Patients With Breast Cancer Undergoing Chemotherapy After Surgery
Status: COMPLETED
Conditions: Cognitive/Functional Effects|Recurrent Breast Cancer|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: PROCEDURE: ultrasound imaging|OTHER: questionnaire administration|PROCEDURE: assessment of therapy complications|PROCEDURE: quality-of-life assessment|PROCEDURE: magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Stepped-Care Telehealth for Distress in Cancer Survivors
Status: COMPLETED
Conditions: Anxiety|Depressive Symptoms|Sleep Disturbance|Recurrent Disease|Fatigue|Quality of Life|Cancer
Interventions: OTHER: Severe Anxiety/depression: High Intensity Stepped Care|OTHER: Moderate Anxiety/depression: Low Intensity Stepped care|OTHER: Enhanced Usual Care Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Efficacy of Alcohol After Betadine and Combination of Alcohol and Betadine on Inflammation Vascular Access
Status: UNKNOWN
Conditions: Complication of Hemodialysis
Interventions: OTHER: Alcohol and povidone iodine|OTHER: combination of alcohol and betadin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence Study of Riociguat 2.5 mg Film Coated Tablets and Adempas (Riociguat) 2.5 mg Film Coated Tablets
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Riociguat film coated tablets|DRUG: Adempas Filmtabletten
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Acupuncture on Inflammation and Immune Function After Craniotomy
Status: COMPLETED
Conditions: Unruptured Cerebral Aneurysm|Hemifacial Spasm|Brain Tumor
Interventions: DEVICE: acupuncture|OTHER: conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Soft Contact Lenses on Lid-Parallel Conjunctival Folds
Status: COMPLETED
Conditions: Lid-Parallel Conjunctival Folds
Interventions: DEVICE: Spectacle Lens|DEVICE: Habitual Soft Contact Lens|DEVICE: Test Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Four-Week Oral Malodor and Clinical Safety for a Concentrated Cosmetic Mouthwash
Status: ENROLLING_BY_INVITATION
Conditions: Oral Malodor
Interventions: OTHER: Brush / Espresso Mild Prototype|OTHER: Brush / Espresso Intense Prototype|OTHER: Brush / Fresh Breath Oral Rinse|OTHER: Brush / Hydroalcohol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT