pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Tolerability, Safety and Efficacy of RKI983 Eye Drops in Subjects With Primary Open Angle Glaucoma and Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: RKI983
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Early-Phase Study to Assess Inhibitor Ribociclib in Patients With Recurrent Glioblastoma or Anaplastic Glioma
Status: UNKNOWN
Conditions: Glioblastoma|Glioma
Interventions: DRUG: Ribociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravascular Injection Rate During Lumbar Transforaminal Epidural Block Using Bent or Straight Needles
Status: RECRUITING
Conditions: Analgesia, Epidural
Interventions: DEVICE: Straight needle|DEVICE: Bent needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Apnea in Hospitalized Preterm Infants Following the Administration of Routine Childhood Vaccines
Status: COMPLETED
Conditions: Apnea|Apnea Neonatal|Prematurity
Interventions: BIOLOGICAL: PCV13|BIOLOGICAL: DTaP|BIOLOGICAL: HBV|BIOLOGICAL: IPV|BIOLOGICAL: Hib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess Safety,and Tolerability of 2 Doses of AZD9773 (CytoFab™) in Japanese With Severe Sepsis/Septic Shock
Status: COMPLETED
Conditions: Severe Sepsis|Septic Shock
Interventions: DRUG: AZD9773|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Pharmacokinetics of Single Dose Oral Tetrahydrocannabinol and Cannabidiol
Status: RECRUITING
Conditions: Cannabis|Chronic Kidney Diseases|Dialysis
Interventions: DRUG: Tetrahydrocannabinol-Cannabidiol Combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Broccoli Effect on Glycated Haemoglobin (HbA1c)
Status: ENROLLING_BY_INVITATION
Conditions: Pre-diabetes
Interventions: OTHER: Broccoli soup|OTHER: Courgette soup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Train of Four, Tetanus 50 and 100 Hz Recovery After Rocuronium Block Reversed by Sugammadex
Status: COMPLETED
Conditions: Postoperative Residual Curarization
Interventions: DEVICE: TOF SCAN|DEVICE: ITF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prevention of Potentially Inappropriate Prescribing in Late Life Using Screening Tool of Older Persons' Potentially Inappropriate Prescriptions (STOPP) and Screening Tool to Alert Doctors to Right Treatment (START) Criteria
Status: UNKNOWN
Conditions: Healthy
Interventions: OTHER: STOPP/START criteria
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effects of Andriol Testocaps in Symptomatic Late-Onset Hypogonadism (43203)
Status: COMPLETED
Conditions: Hypogonadism|Androgens
Interventions: DRUG: Oral testosterone undecanoate (Andriol)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating The Efficacy And Safety Of CP-690,550 In Asian Subjects With Moderate To Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: placebo|DRUG: CP-690,550|DRUG: CP-690,550
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of FP-1201-lyo (Interferon Beta-1a) in Patients Having Acute Respiratory Distress Syndrome (ARDS)
Status: TERMINATED
Conditions: Respiratory Distress Syndrome, Adult
Interventions: DRUG: Interferon beta-1a|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation With Or Without Traumatic Stimuli in Post Traumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: Flashbacks|Posttraumatic Stress Disorder
Interventions: DEVICE: rapid TMS, EXPOSURE TO TRAUMATIC STIMULI|DEVICE: rapid TMS, EXPOSURE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: VIGIP-SEP2: Evaluation of the Impact of the Training of Patients by a Nurse on the Adverse Drug Reaction Reporting by RRMS Patient Via a Mobile Application: Randomized Real-life Study
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: OTHER: nurse training of the patient|OTHER: neurologist accompaniement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dexmedetomidine vs Dexamethasone in Popliteal Nerve Block
Status: NOT_YET_RECRUITING
Conditions: Ankle Disease|Ankle Injuries and Disorders|Foot Injury|Foot Diseases
Interventions: DRUG: 0.9% Sodium chloride|DRUG: 0.1mg/kg Dexamethasone|DRUG: 0.05ug/kg Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Long-term Administration Study of OPC-41061 in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD) (2) [Extension of Study 156-05-002]
Status: COMPLETED
Conditions: Autosomal Dominant Polycystic Kidney Disease
Interventions: DRUG: OPC-41061
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postprandial Glycemia and Satiety of Meals With Potatoes, With and Without Protein
Status: RECRUITING
Conditions: Glycemic Control|Satiety Response|Appetite Regulation|Diabetes|Obesity
Interventions: OTHER: Ad libitum full-fat French fries with beef meatballs|OTHER: Ad libitum instant mashed potatoes with beef meatballs|OTHER: Ad libitum macaroni pasta with beef meatballs|OTHER: Ad libitum full-fat French fries with vegetarian substitute meatballs|OTHER: Ad libitum instant mashed potatoes with vegetarian substitute meatballs|OTHER: Ad libitum macaroni pasta with vegetarian substitute meatballs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Dazucorilant in Patients With Amyotrophic Lateral Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Dazucorilant 300 mg|DRUG: Dazucorilant 150 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Development of a Nationally Scalable Model of Group Prenatal Care to Improve Birth Outcomes: "Expect With Me"
Status: COMPLETED
Conditions: Pregnancy|Premature Birth|Infant, Low Birth Weight|Postpartum Period|Sexually Transmitted Diseases
Interventions: BEHAVIORAL: Expect With Me group prenatal care|OTHER: Standard individual prenatal care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of tDCS Along With Relaxation Technique on Anxiety Level in Students Preparing for Competitive Exams
Status: RECRUITING
Conditions: Anxiety
Interventions: DEVICE: tDCS|OTHER: Relaxation technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Radiation Fractionation Schedules for Once-a-Day Accelerated Partial Breast Irradiation
Status: COMPLETED
Conditions: Breast Cancer|DCIS
Interventions: RADIATION: APBI: 30 Gy|RADIATION: APBI: 27.5 Gy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NM-IL-12 in Cutaneous T-Cell Lymphoma (CTCL) Undergoing Total Skin Electron Beam Therapy (TSEBT)
Status: UNKNOWN
Conditions: Cutaneous T Cell Lymphoma (CTCL)|Mycosis Fungoides|Sézary Syndrome
Interventions: BIOLOGICAL: NM-IL-12 and TSEBT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-dose Baricitinib Plus High-dose Dexamethasone for Patients With Newly Diagnosed Immune Thrombocytopenia
Status: RECRUITING
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Baricitinib 2 MG|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SP16 as a Therapeutic for COVID-19 Induced ARDS
Status: TERMINATED
Conditions: SARS CoV 2 Infection|Pneumonia
Interventions: DRUG: SP16 (6mg)|OTHER: Placebo|DRUG: SP16 (12 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BENEFITS OF ACLIDINIUM BROMIDE IN THE RELIEF OF COPD SYMPTOMS INCLUDING COUGH
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Aclidinium Bromide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pralatrexate in Female Patients With Previously-treated Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Breast Tumors|Neoplasms, Breast|Cancer of the Breast|Human Mammary Carcinoma
Interventions: DRUG: Pralatrexate Injection|DIETARY_SUPPLEMENT: Vitamin B12|DIETARY_SUPPLEMENT: Folic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abemaciclib (LY2835219) in Men With Heavily Treated Metastatic Castration-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Metastatic Castration-Resistant Prostate Cancer
Interventions: DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Telerehabilitation Versus Clinic-based Task-oriented Circuit Training in Parkinson's Patients
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: OTHER: Task oriented circuit training based telerehabilitation|OTHER: Clinic based Task oriented circuit training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Establishment of a CSF Bank for the Development of Biomarkers of Smooth Muscle Cell (SMC) Damage in Monogenic Cerebral Small Vessel Disease
Status: NOT_YET_RECRUITING
Conditions: Cerebral Small Vessel Diseases|CADASIL (Diagnosis)
Interventions: OTHER: Cerebrospinal fluid (CSF) sample and additional blood samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: the Effects of Epidural Fentanyl on Vaginal Delivery
Status: UNKNOWN
Conditions: Cervical Dilatation|Bishop Score|Duration of Delivery
Interventions: DRUG: Fentanyl|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: BAY12-8039: 5 Days for Sinusitis vs Placebo
Status: COMPLETED
Conditions: Sinusitis
Interventions: DRUG: Moxifloxacin (Avelox, BAY12-8039)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maple Products and Exercise Performance
Status: COMPLETED
Conditions: Carbohydrate Ingestion|Fuel Selection|Athletic Performance
Interventions: DIETARY_SUPPLEMENT: Solution ingestion|BEHAVIORAL: Constant load cycling|PROCEDURE: Expired gas sampling|PROCEDURE: Indirect respiratory calorimetry|OTHER: Palatability|OTHER: Gastrointestinal|PROCEDURE: Blood sampling|BEHAVIORAL: Time trial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Augmented-Reality CTA Plus Angiography vs Angiography Alone for Guiding PCI in Coronary Lesions - Randomized Study
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Angiographic guided PCI|PROCEDURE: Augmented-Reality CTA guided PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short-course Radiotherapy (5×6Gy/7Gy/8Gy) Followed by Neo-adjuvant Chemotherapy for Locally Advanced Rectal Cancer
Status: RECRUITING
Conditions: Radiation Oncology|Rectal Cancer
Interventions: RADIATION: preoperative short-course radiotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Yoga and Pilates Based Respiratory Training Effect for Individuals With Urinary Incontinence
Status: RECRUITING
Conditions: Urinary Incontinence
Interventions: OTHER: Yoga-Based Respiration Training|OTHER: Pilates-Based Respiration Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Premedication for Less Invasive Surfactant Administration Study (PRELISA)
Status: RECRUITING
Conditions: Respiratory Distress Syndrome, Newborn
Interventions: DRUG: IV Atropine and Fentanyl Premedication Arm|DRUG: IV Normal Saline Placebo Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic and Bio-behavioral Effects of Following Recommendations in the Dietary Guidelines for Americans
Status: RECRUITING
Conditions: Obesity|Body Weight
Interventions: OTHER: DGA Mediterranean diet pattern, energy balance|OTHER: DGA Mediterranean diet pattern, negative energy balance|OTHER: TAD diet pattern, negative energy balance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lovaza's Effect on Clopidogrel in a Neuro Population
Status: UNKNOWN
Conditions: Ischemic Stroke|Transient Ischemic Attack
Interventions: DIETARY_SUPPLEMENT: omega-3 polyunsaturated fatty acids (Lovaza)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 6x3 Crossover, Bioavailability, Safety and Tolerability Among Different Eutropin Formulations in Healthy Volunteers
Status: COMPLETED
Conditions: Bioavailability, Safety and Tolerability Among Different Eutropin Formulations in Healthy Volunteers
Interventions: DRUG: Somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Whole-course Management of Pegaspargase in ENKTL
Status: NOT_YET_RECRUITING
Conditions: Extranodal NK/T Cell Lymphoma
Interventions: DRUG: Pegaspargase（P-GOD）|DRUG: Pegaspargase（PEMD）
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Bromocriptine, Metoprolol and Tamsulosin in Eyes With Non-Central DME
Status: WITHDRAWN
Conditions: Diabetic Macular Edema
Interventions: DRUG: Bromocriptine 2.5 MG|DRUG: Metoprolol 25 MG|DRUG: Tamsulosin 0.4 MG|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Lurbinectedin in Combination With Irinotecan in Patients With Selected Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors|Glioblastoma|Soft Tissue Sarcoma (Excluding GIST)|Endometrial Carcinoma|Epithelial Ovarian Carcinoma|Mesothelioma|Gastroenteropancreatic Neuroendocrine Tumor|SCLC|Gastric Carcinoma|Pancreatic Adenocarcinoma|Colorectal Carcinoma|Neuroendocrine Tumors
Interventions: DRUG: Lurbinectedin|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Model-based Health Education Program to Improve Oral Health in School Going Children
Status: COMPLETED
Conditions: Oral Health
Interventions: BEHAVIORAL: Education program based on health belief model to improve oral health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Calcitriol in Preventing Lung Cancer in Smokers and Former Smokers at High Risk of Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer|Precancerous Condition|Tobacco Use Disorder
Interventions: DRUG: calcitriol|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Interleukin-6 Receptor Inhibition in Patients With Ischemic Stroke Undergoing Endovascular Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Interleukin-6|Ischemic Stroke|Endovascular Treatment
Interventions: DRUG: Tocilizumab|DRUG: NaCl 0.9% 100ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Thai Massage on Patients With Wrist Extensor Muscles Latent Myofascial Trigger Points
Status: COMPLETED
Conditions: Patients With Latent Myofascial Trigger Point
Interventions: OTHER: Thai massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Studying Biomarkers in Samples From Younger Patients With Malignant Germ Cell Tumor Progression
Status: COMPLETED
Conditions: Childhood Germ Cell Tumor|Extragonadal Germ Cell Tumor|Ovarian Cancer|Testicular Germ Cell Tumor
Interventions: GENETIC: DNA methylation analysis|GENETIC: RNA analysis|GENETIC: mutation analysis|GENETIC: nucleic acid sequencing|GENETIC: polymerase chain reaction|GENETIC: polymorphism analysis|OTHER: laboratory biomarker analysis|OTHER: medical chart review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effectiveness of HP and TMZ Synergism on Adult Recurrence GBM
Status: NOT_YET_RECRUITING
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Haloperidol Tablets|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)
Status: NOT_YET_RECRUITING
Conditions: Kidney Disease, Chronic
Interventions: DRUG: BI 690517|DRUG: Placebo matching BI 690517|DRUG: Empagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention Of Nephrotoxicity Following Bone Marrow Transplantation Using Urodilatin and Mannitol
Status: COMPLETED
Conditions: Renal Dysfunction|Acute Renal Failure|Mortality
Interventions: DRUG: URODILATIN (ULARITIDE, ATRIAL NATRIURETIC PEPTIDE)|DRUG: MANNITOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Niraparib Efficacy in Patient With Unresectable Mesothelioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Mesothelioma, Malignant
Interventions: DRUG: Niraparib Oral Product|OTHER: Active Symptom Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Documented Candida or Aspergillus Infections in Pediatric Patients (0991-043)
Status: COMPLETED
Conditions: Aspergillosis|Candidiasis
Interventions: DRUG: caspofungin acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck
Status: RECRUITING
Conditions: Cancer|Carcinoma|Squamous Cell Carcinoma|Head and Neck Cancer
Interventions: BIOLOGICAL: Atezolizumab|BIOLOGICAL: Tocilizumab|BIOLOGICAL: Tiragolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tumor Tissue Analysis in Patients Receiving Imatinib Mesylate for Malignant Glioma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: imatinib mesylate|OTHER: pharmacological study|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety Tolerability Pharmacokinetics, and Pharmacodynamics of Inhaled and Intravenous GSK2862277 in Healthy Volunteers
Status: COMPLETED
Conditions: Respiratory Disorders
Interventions: DRUG: Single IV dose of GSK2862277|DRUG: Matching placebo single dose IV infusion|DRUG: Single IH dose of GSK2862277|DRUG: Matching placebo single dose IH|DRUG: Repeat IV dose of GSK2862277|DRUG: Matching placebo repeat dose IV infusion|DRUG: Repeat IH dose selected of GSK2862277 from Part 2|DRUG: Matching placebo repeat dose IH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: ARAPS Study on Accelerated Liver Regeneration
Status: UNKNOWN
Conditions: Liver Regeneration|Liver Cancer|Liver Metastases|Liver Failure
Interventions: PROCEDURE: ARAPS|PROCEDURE: PVE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Website Smoking Cessation Intervention for the Promotion of Smoking Cessation in Low-Income Veterans
Status: COMPLETED
Conditions: Cigarette Smoking-Related Carcinoma
Interventions: BEHAVIORAL: Smoking Cessation Intervention (New website)|BEHAVIORAL: Smoking Cessation Intervention (Standard of care website)|BEHAVIORAL: Health Education|OTHER: Health Promotion and Education|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Antineoplaston Therapy in Treating Patients With Stomach Cancer
Status: TERMINATED
Conditions: Stomach (Gastric) Cancer
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PD-1 Blockade Combined With Definitive Chemoradiation in Locoregionally-advanced Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Neoplasms
Interventions: DRUG: Sintilimab|DRUG: Gemcitabine|DRUG: Cisplatin|RADIATION: intensity-modulated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quality of Life Improvement in Dry Eye Patients After Intense Pulsed Light Therapy Compared to Punctal Plugs
Status: COMPLETED
Conditions: Evaporative Dry Eye
Interventions: PROCEDURE: IPL therapy|PROCEDURE: Punctal plugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Summer Camp Study 2: Blood Glucose Control With a Bi-Hormonal Endocrine Pancreas
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: Bionic Pancreas|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Cemiplimab and ISA101b in Patients With Recurrent/Metastatic HPV16 Positive OPC
Status: ACTIVE_NOT_RECRUITING
Conditions: Squamous Cell Carcinoma of the Oropharynx
Interventions: DRUG: ISA101b
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety And Efficacy Of TKI Cessation For CML Patients With Stable Molecular Response In A Real World Population
Status: RECRUITING
Conditions: Chronic Myeloid Leukemia|Chronic Myeloid Leukemia, BCR/ABL-Positive, in Remission|Chronic Myeloid Leukemia in Remission
Interventions: OTHER: Imatinib Mesylate, Dasatinib, Nilotinib or Bosutinib Withdrawal|DRUG: Imatinib Mesylate, Dasatinib, Nilotinib or Bosutinib Re-initiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Safety Study of Lusutrombopag (S-888711) in Adults With Chronic Immune Thrombocytopenia (ITP)
Status: TERMINATED
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Lusutrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease (AD)
Status: COMPLETED
Conditions: Alzheimer Disease|Cognitive Dysfunction|Mild Dementia
Interventions: DRUG: SAGE-718
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Safety and Effectiveness of Indinavir Combined With Stavudine and Lamivudine
Status: SUSPENDED
Conditions: HIV Infections
Interventions: DRUG: L-756423|DRUG: Indinavir sulfate|DRUG: Lamivudine|DRUG: Stavudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study for the Liquid Chromatography-mass Spectrometry (LC-MS/MS) Assessment of Oxidative DNA Damage in Relation to Antioxidant Usage
Status: COMPLETED
Conditions: Cancer
Interventions: DIETARY_SUPPLEMENT: 1 tablet composed of antioxidants and minerals
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Hepatic Arterial Infusion to Treat Biliary Tract Carcinomas
Status: COMPLETED
Conditions: Biliary Tract Cancer
Interventions: DRUG: Oxaliplatin, Fluorouracil, Leucovorin, Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: O-SEMA-Fast: A Research Study to Understand How Oral Semaglutide Works in People With Type 2 Diabetes Who Plan to Fast During Ramadan in the United Arab Emirates, Saudi Arabia, and Kuwait
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Exploratory Study of Nesiritide in Participants With Acute Heart Failure
Status: COMPLETED
Conditions: Heart Failure, Congestive
Interventions: DRUG: Nesiritide (1+0.01)|DRUG: Nesiritide (2+0.005)|DRUG: Nesritide (2+0.01)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GABA-B Receptor Function in Healthy Volunteers
Status: COMPLETED
Conditions: No Condition|Brain GABA-B Function
Interventions: DRUG: Baclofen 10mg|DRUG: Baclofen 60mg|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of GLP-1 Receptor Agonism After Sleeve Gastrectomy
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Saxenda|DRUG: Placebos|PROCEDURE: RYGB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Metabolism Study to Investigate the Impact of a Sequential Oral Contraceptive
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: EV/DNG (Qlaira, BAY86-5027, SH T00658K)|DRUG: SH D00264A (Triquilar)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase I, Multicenter Dose Escalation Study in Patients With Hairy Cell Leukemia
Status: COMPLETED
Conditions: Hairy Cell Leukemia
Interventions: DRUG: Moxetumomab Pasudotox (CAT 8015)|DRUG: Moxetumomab Pasudotox (CAT 8015)|DRUG: Moxetumomab Pasudotox (CAT 8015)|DRUG: Moxetumomab Pasudotox (CAT 8015)|DRUG: CAT 8015 (Moxetumomab Pasudotox)|DRUG: Moxetumomab Pasudotox (CAT 8015)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of CollaRx® Bupivacaine Implant in Men After Open Laparotomy Herniorrhaphy
Status: COMPLETED
Conditions: Herniorrhaphy|Postoperative Pain|Inguinal Hernia
Interventions: DRUG: Bupivacaine Collagen Sponge|DRUG: Placebo collagen Sponge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MR-Guided Laser Interstitial Thermal Therapy in Treating Patients With Prostate Cancer
Status: COMPLETED
Conditions: Stage I Prostate Cancer|Stage II Prostate Carcinoma
Interventions: DEVICE: Visualase Thermal Therapy|PROCEDURE: magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First Step With Singulair® Therapy (0476-323)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: MK0476 (singulair), montelukast sodium / Duration of Treatment: 6 Weeks|DRUG: Comparator: Fluticasone / Duration of Treatment: 6 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Iron Deficiency Anemia During Pregnancy
Status: COMPLETED
Conditions: Iron Deficiency Anemia
Interventions: DRUG: Ferrous bis-glycinate|DRUG: Ferrous glycine sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Laparoscopic Splenectomy on Liver Reserve Function for Cirrhosis Patients
Status: RECRUITING
Conditions: Cirrhosis, Liver|Splenectomy; Status
Interventions: PROCEDURE: Laparoscopic splenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Airbag-type Stretchable Electrode Array（ASEA） for Electrical Stimulation in Urinary Incontinence in Postmenopausal Women
Status: RECRUITING
Conditions: Urinary Incontinence|Pelvic Floor Muscle Training
Interventions: DEVICE: airbag-type stretchable electrode array (ASEA) device|DEVICE: two-channel hard electrode device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial of Sunitinib and/or Nivolumab Plus Chemotherapy in Advanced Soft Tissue and Bone Sarcomas
Status: COMPLETED
Conditions: Soft Tissue Sarcoma|Bone Sarcoma
Interventions: DRUG: Sunitinib 37.5 MG, Sunitinib 25 MG [Sutent]|DRUG: Nivolumab 100 MG/10 ML [Opdivo]|DRUG: Epirubicin|DRUG: Ifosfamide|DRUG: Doxorubicin|DRUG: Dacarbazine|DRUG: Cisplatin|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy, Safety and Injection Technique of Restylane Lip Volume and Restylane Lip Refresh
Status: COMPLETED
Conditions: Injection Techniques
Interventions: DEVICE: Restylane Lip Volume|DEVICE: Restylane Lip Refresh
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Macitentan and Tadalafil Film-coated Tablets 10 mg/40 mg and 'PrOpsynvi®' Macitentan and Tadalafil Film-coated Tablets 10 mg/40 mg
Status: COMPLETED
Conditions: PAH
Interventions: DRUG: Macitentan and Tadalafil film-coated tablets|DRUG: PrOpsynvi® macitentan and tadalafil film-coated tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: CPX-351 in Combination With Gemtuzumab Ozogamicin in Newly Diagnosed AML
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Vyxeos|DRUG: Gemtuzumab Ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Pegylated Interferon Lambda With and Without Daclatasvir, Compared to Pegylated Interferon Alfa, Plus Ribavirin in Subjects With Hepatitis C Genotype 2 and 3
Status: COMPLETED
Conditions: Hepatitis C Virus (HCV)
Interventions: BIOLOGICAL: Pegylated interferon lambda (pegIFNλ)|BIOLOGICAL: Pegylated interferon lambda (pegIFNλ)|BIOLOGICAL: Pegylated interferon alfa-2a (pegIFNα-2a)|DRUG: Ribavirin|DRUG: Ribavirin|DRUG: Daclatasvir|DRUG: Placebo matching Daclatasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Mass Balance, Pharmacokinetics (PK), Metabolism and Excretion of TAK-954 Containing Microtracer ([14C]-TAK-954) in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: [14C]-TAK-954
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Left Atrial Appendage (LAA) Occluders After Catheter Ablation of Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: LAA occluder|PROCEDURE: RFA ablation|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Venetoclax in Combination With Low-dose HHT, G-CSF, and AZA as First-line Treatment for Newly Diagnosed Elderly AML Patients Unfit for Intensive Chemotherapy
Status: UNKNOWN
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: The combination of HHT, venetoclax, AZA, G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pressure Massage and Topical Gel on Pain During Intra Oral Injections
Status: COMPLETED
Conditions: Normal Pulp/ Pulpitis
Interventions: DRUG: 20% Benzocain (Master-Dent, Monroe, NC)|OTHER: Topical pressure massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Graft Patency After FFR-guided Versus Angio-guided CABG (GRAFFITI) Trial
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Surgical revascularization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Accuracy Comparison: Optoelectronic Motion Capture and Markerless System
Status: ACTIVE_NOT_RECRUITING
Conditions: Children, Adult|Motor Disorders
Interventions: OTHER: Measure gait spatiotemporal parameters and kinematics from optoelectronic system|OTHER: Measure gait spatiotemporal parameters and kinematics from markerless system
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Beneficial Side Effects of Topiramate in Obese Patients Undergoing Total Joint Arthroplasty
Status: WITHDRAWN
Conditions: Weight Loss|Pain, Postoperative
Interventions: DRUG: Topamax|DRUG: Gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fish Oil to Reduce Tobacco Use iN Expectant Mothers Study
Status: COMPLETED
Conditions: Tobacco Use in Childbirth|Smoking Cessation|Pregnancy Related
Interventions: DRUG: Fish oil|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Almonertinib Followed by Chemo-immunotherapy in II-IIIB EGFR-mutant NSCLC
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer|EGFR Gene Mutation
Interventions: DRUG: almonertinib|DRUG: Carboplatin|DRUG: Nab paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Inhaled Treprostinil in Fontan Patients
Status: TERMINATED
Conditions: Congenital Heart Disease
Interventions: DRUG: Treprostinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Virtual Clinic Pacemaker Follow-up
Status: TERMINATED
Conditions: Sick Sinus Syndrome|Heart Block|Bradycardia
Interventions: DEVICE: Home Monitoring of pacemaker|DEVICE: Home Monitoring of pacemaker deactivated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Progesterone Effect on Individuals Diagnoses With AD and PTSD.
Status: COMPLETED
Conditions: Alcohol Dependence|Post-Traumatic Stress Disorder (PTSD)
Interventions: DRUG: Progesterone|DRUG: Placebo (for Progesterone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimized Chemotherapy Followed by Maintenance With Bevacizumab With or Without Erlotinib in Treating Patients With Metastatic Colorectal Cancer That Cannot be Removed by Surgery (DREAM)
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: bevacizumab|DRUG: bevacizumab, erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Trimetrexate With Leucovorin Rescue for AIDS Patients Who Are Refractory to Standard Therapies for Pneumocystis Carinii Pneumonia
Status: COMPLETED
Conditions: Pneumonia, Pneumocystis Carinii|HIV Infections
Interventions: DRUG: Trimetrexate glucuronate|DRUG: Leucovorin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Level Laser Therapy in the Treatment of Temporomandibular Joint Disorders (TMJDs) Related Pain
Status: COMPLETED
Conditions: Temporomandibular Joint Disorders
Interventions: DEVICE: B-Cure® diode laser|DEVICE: B-Cure® diode laser sham device|DRUG: Nimesulide Ratiopharm® and Flexiban®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: rTMS for the Treatment of Chronic Tinnitus: Optimization by Simulation of the Cortical Tinnitus Network
Status: COMPLETED
Conditions: Chronic Tinnitus
Interventions: DEVICE: rTMS intervention 1|DEVICE: rTMS intervention 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neurofeedback During Eating for Bulimia Nervosa
Status: RECRUITING
Conditions: Bulimia Nervosa
Interventions: OTHER: Real fNIRS Neurofeedback|OTHER: Sham-Control fNIRS Neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Three Modalities of Spontaneous Breathing Tests on Respiratory Efforts in Tracheostomized Patients
Status: UNKNOWN
Conditions: Mechanical Ventilation Complication
Interventions: PROCEDURE: Modality 1|PROCEDURE: Modality 2|PROCEDURE: Modality 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Hematoma Block Versus Bier Block for Closed Fracture Reduction
Status: ENROLLING_BY_INVITATION
Conditions: Distal Radius Fractures
Interventions: DRUG: Hematoma Local Anesthetic Block Procedure with 1% Lidocaine|DRUG: Bier Anesthetic Block Procedure with 1% Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Lifestyle Study: Effects and Expense of a Cardiovascular Risk Reduction Clinic in Primary Care
Status: UNKNOWN
Conditions: Hypertension|Hyperlipidemia|Hyperglycemia|Cardiovascular Disease|Smoking
Interventions: BEHAVIORAL: Cardiovascular risk factors and willingness to change
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Ultrasound-Guided Erector Spinae Plan Block in Patients Undergoing ESWL
Status: UNKNOWN
Conditions: Urinary System Stones|Pain
Interventions: DRUG: Bupivacaine HCl 0.5 % in 10 ml and 2 % lidocaine in 10 ml|DRUG: 5 % Lidocaine Topical Gel and 800 mg ibuprofen intravenously
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Pegvisomant on GH/IGF-I Relationship in GHD
Status: TERMINATED
Conditions: Severe Adult Growth Hormone Deficiency
Interventions: DRUG: pegvisomant/placebo loading dose 80mg sc, thereafter 20mg daily for 2 weeks|PROCEDURE: GH sampling - every 20 min over 24 hours after each limb (pegvisomant/placebo)|PROCEDURE: blood sampling before and after pegvisomant/placebo|PROCEDURE: arginine stimulation test after each limb
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose:
Clinical trial: Night-time Dexmedetomidine-esketamine Infusion and Sleep Quality With Mechanical Ventilation
Status: RECRUITING
Conditions: Intensive Care Unit|Mechanical Ventilation|Dexmedetomidine|Esketamine|Sleep Quality
Interventions: DRUG: Dexmedetomidine-esketamine|DRUG: Propofol-remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Two Daily Wear Silicon Hydrogel Contact Lens
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Biofinity soft contact lens|DEVICE: Visco soft contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Exenatide in Japanese Patients With Type 2 Diabetes Who Are Treated With Oral Antidiabetic(s)
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: exenatide|DRUG: exenatide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ociperlimab With Tislelizumab Compared to Pembrolizumab in Participants With Untreated Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer|NSCLC
Interventions: DRUG: Tislelizumab|DRUG: Ociperlimab|DRUG: Pembrolizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Research of Human Retinal Pigment Epithelial (HuRPE) Cell Injection on Atrophy of High Myopia Macular Area
Status: UNKNOWN
Conditions: Degenerative Myopia With Macular Hole
Interventions: OTHER: Human retinal pigment epithelial (HuRPE) cell injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NovoTTF-200A and Temozolomide Chemoradiation for Newly Diagnosed Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma, Adult
Interventions: DEVICE: NovoTTF-200A|DRUG: Temozolomide|RADIATION: 3D conformal or intensity modulated radiation therapy (IMRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modified Breath Test to Determine Anabolic Sensitivity Across Physical Activity States
Status: RECRUITING
Conditions: Resistance Exercise|Physical Inactivity|Amino Acids|Dietary Protein
Interventions: BEHAVIORAL: Habitual Activity|BEHAVIORAL: Step-Reduction|BEHAVIORAL: Resistance Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Pharmacokinetics of Kovacaine Nasal Spray (24 Hour Blood Collection)
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Tetracaine HCl 3% and Oxymetazoline HCl 0.05%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT