pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Virtual Environments for Vestibular Rehabilitation
Status: COMPLETED
Conditions: Dizziness Chronic|Vertigo, Peripheral|Fall
Interventions: BEHAVIORAL: Balance training|BEHAVIORAL: Traditional Vestibular Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Effect of Superba Boost on the Skin.
Status: COMPLETED
Conditions: Physiology, Skin
Interventions: DIETARY_SUPPLEMENT: Superba Boost (Active)|DIETARY_SUPPLEMENT: Vegetable oil (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Radiation Therapy Plus Chemotherapy in Treating Patients With Supratentorial Glioblastoma Multiforme
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: carmustine|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of CARTOSOUND FAM Software for Accurate Reconstruction of the Left Atrium
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Evaluation of CARTOSOUND-FAM software for accurate three-dimensional reconstruction of the left atrium in patients referred for atrial fibrillation ablation.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Phase I Study of PDC-1421 Capsule Targeting in Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: PDC-1421|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study to Determine the Cartography of Virologic Reservoir Related to Antiretroviral Concentrations in HIV-1 Chronic Patients Treated by a First Line Treatment Containing bictégravir, Emtricitabine and ténofovir alafénamide
Status: NOT_YET_RECRUITING
Conditions: HIV-1-infection
Interventions: OTHER: Biopsies and bloood samplings
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sildenafil in Hemodialysis Patients With Pulmonary Hypertension
Status: UNKNOWN
Conditions: Pulmonary Hypertension|Hemodialysis Complication
Interventions: DRUG: Sildenafil|DRUG: Sildenafil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Femoral and Epidural Block After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Acute Postoperative Pain|Chronic Postoperative Pain
Interventions: OTHER: DN4 test|OTHER: The SF 12 test|OTHER: HAD scale|OTHER: Visual analogue score|PROCEDURE: femoral block|PROCEDURE: epidural block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Adiponectin, IL-6 and hsC-RP in Relation to Carotid Intima-media Thickness in B-thalassemia Patients
Status: COMPLETED
Conditions: Thalassemia
Interventions: DIAGNOSTIC_TEST: Interleukin-6|DIAGNOSTIC_TEST: HsC-RP|DIAGNOSTIC_TEST: Adiponectin level|DIAGNOSTIC_TEST: Carotid intima media thickness
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pre-op Femoral Nerve Block for Hip Fracture
Status: TERMINATED
Conditions: Hip Fractures
Interventions: PROCEDURE: Continuous femoral nerve block|DRUG: 0.5% Ropivacaine/0.125% Bupivacaine local anesthetic mixture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Nifedipine Versus Indomethacin for Acute Preterm Labor
Status: COMPLETED
Conditions: Obstetric Labor, Premature
Interventions: DRUG: Nifedipine|DRUG: Indomethacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endobiliary RFA for Unresectable Malignant Biliary Strictures
Status: COMPLETED
Conditions: Cholangiocarcinoma|Ampullary Carcinoma
Interventions: PROCEDURE: Radiofrequency ablation (RFA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Bone-Myoregulation Reflex and Development of Sarcopenia in Osteoporosis
Status: COMPLETED
Conditions: Sarcopenia|Osteoporosis
Interventions: DEVICE: whole-body vibration to Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Using Ongoing Newborn Intervention Trials to Obtain Additional Data Critical to Maternal, Fetal and Newborn Health in a Harmonized Way
Status: COMPLETED
Conditions: Maternal Deaths|Neonatal Deaths|Still Births
Interventions: OTHER: This is an observational study being conducted as a substudy of antoher trial.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence Between WE 941 OD and Brotizolam (Lendormin®) Taken With Water in Healthy Adult Males
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: WE 941 OD tablets|DRUG: Brotizolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Magnesium-rich Artificial Cerebrospinal Fluid in Aneurysmal Subarachnoid Hemorrhage
Status: UNKNOWN
Conditions: Aneurysmal Subarachnoid Hemorrhage
Interventions: OTHER: Magnesium-Rich Artificial Cerebrospinal Fluid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Survey of Oticon Medical Ponto BHX Implant
Status: COMPLETED
Conditions: Hearing Impaired (Partially)|Hearing Impairment, Conductive|Deafness Unilateral
Interventions: DEVICE: BHX implant (Bone anchored hearing system)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Controlled Trial of Eculizumab in Adult Patients With Plasma Therapy-Resistant aHUS
Status: COMPLETED
Conditions: Atypical Hemolytic Uremic Syndrome
Interventions: DRUG: Eculizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Efficacy of Metadoxine as a Therapy for Patients With Non-alcoholic Steatohepatitis
Status: WITHDRAWN
Conditions: Non-alcoholic Steatohepatitis
Interventions: DRUG: metadoxine|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ProspEctive Cohort Study on Multidisciplinary Approach to Femur FRactures' manAgement in Over 65 Population
Status: COMPLETED
Conditions: Hip Fractures|Intertrochanteric Fractures|Femur Fracture
Interventions: PROCEDURE: IMN-Group|PROCEDURE: HA-Group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Between a Non-elastic Falcro Device and Current Method After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Lymphedema
Interventions: DEVICE: New non-elastic compression kit|DEVICE: current compression stocking Comprinet®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Biomolecular Messages Associated With the Differentiation of Human Induced Pluripotent Stem Cells to Skeletal Muscle Progenitor Cells
Status: UNKNOWN
Conditions: Female Urinary Incontinence and Pelvic Organ Prolapse
Interventions: OTHER: Differentiation of hiPSCs to skeletal muscle progenitors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Breathing Exercises in Women With Chronic Pelvic Pain
Status: NOT_YET_RECRUITING
Conditions: Chronic Pelvic Pain Syndrome|Pelvic Floor; Relaxation|Breathing Exercises|Women
Interventions: OTHER: Breathing Exercises|OTHER: Pelvic Floor Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Long Term Safety and Efficacy of SC Apomorphine in Treatment of "Off" Episodes in Late-Stage Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: apomorphine HCl injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention Effect of High Definition Transcranial Direct Current Stimulation (HD-tDCS) on Depressive Disorder
Status: UNKNOWN
Conditions: Transcranial Direct Current Stimulation|Functional Magnetic Resonance Imaging|Depressive Disorder
Interventions: DEVICE: High definition transcranial direct current stimulation|DEVICE: sham high definition transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Genotype and Platelet Reactivity in Patients on Hemodialysis
Status: UNKNOWN
Conditions: Chronic Kidney Disease
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Intermediate Cervical Block Versus Superficial Cervical Block for Carotid Endarterectomy (CERVECHO)
Status: COMPLETED
Conditions: Carotid Atherosclerosis|Regional Anaesthesia Morbidity
Interventions: OTHER: Ultrasound-guided administration of ropivacaine 4.75 mg/ml|OTHER: landmark based superfical ropivacaine 4.75 mg/ml injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Atazanavir or Lopinavir in HIV Post-exposure Prophylaxis
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Combivir+Kaletra|DRUG: Combivir+Reyataz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Toripalimab Combined With Apatinib Mesylate for the Treatment of Gastric Adenocarcinoma in a Prospective Randomized Multicenter Phase II Clinical Study
Status: UNKNOWN
Conditions: Gastric Adenocarcinoma
Interventions: DRUG: Toripalimab+Apatinib mesylate|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Vitamin A in Fortified Extruded Rice in School Children
Status: COMPLETED
Conditions: Vitamin A Deficiency
Interventions: DIETARY_SUPPLEMENT: Triple fortified extruded tice (Fe, Zn and vitamin A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of SGLT2 Inhibition on OCT-A Parameters in Diabetic CKD
Status: UNKNOWN
Conditions: Diabetic Retinopathy|Chronic Kidney Diseases|Diabetes Mellitus
Interventions: DRUG: Empagliflozin 25 MG|DEVICE: OCT-A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess LBL-007 in Combination With Toripalimab and Axitinib Tablets Subjects With Advanced Melanoma
Status: RECRUITING
Conditions: Advanced Melanoma
Interventions: DRUG: LBL-007|DRUG: Toripalimab|DRUG: Axitinib Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Dose Escalation Trial of a Densified Chemotherapy Association of Docetaxel and Epirubicin Driven by Mathematical Modeling in Metastatic Breast Cancer Patients: The MODEL1 Study
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Combination of Docetaxel (DTX) and Epirubicin (EPI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Red Blood Cell Transfusion in Patients With Coronary Artery Disease (CAD)
Status: TERMINATED
Conditions: Acute Coronary Syndrome|Anemia
Interventions: OTHER: RBC transfusion|OTHER: Normal saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: First-time Ablation of Atrial Fibrillation Registry
Status: RECRUITING
Conditions: Atrial Fibrillation|Arrhythmia
Interventions: DIAGNOSTIC_TEST: PPG-based remote heart rhythm/rate monitoring|DIAGNOSTIC_TEST: ECG-based remote heart rhythm/rate monitoring|DIAGNOSTIC_TEST: Transthoracic and transesophageal echocardiography examination|DIAGNOSTIC_TEST: Liver ultrasound examination|DIAGNOSTIC_TEST: Rotational angiography with three-dimensional reconstruction|DIAGNOSTIC_TEST: Blood-derived biomarker analysis|DIAGNOSTIC_TEST: Mobile health-based spirometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of MayoExpertAdvisor on Provider Adherence
Status: COMPLETED
Conditions: Hyperlipidemia|Atrial Fibrillation|Heart Failure
Interventions: BEHAVIORAL: MayoExpertAdvisor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Paragastric Autonomic Neural Blockade as Part of Combined Anesthesia.
Status: COMPLETED
Conditions: Opioid Use|Anesthesia Morbidity
Interventions: OTHER: PG-ANB performed at the outset of LSG|OTHER: PG-ANB performed at the end of the LSG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacodynamics Study of MRX34, MicroRNA Liposomal Injection in Melanoma Patients With Biopsy Accessible Lesions
Status: WITHDRAWN
Conditions: Melanoma
Interventions: DRUG: MRX34|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Biomarkers in the Long-term Impact of Coronavirus Infection in the Cardiorespiratory System
Status: UNKNOWN
Conditions: COVID19|Corona Virus Infection|Myocardial Injury|Pneumonia
Interventions: OTHER: BIOMARKERS IN THE LONG TERM IMPACT OF CORONAVIRUS INFECTION IN THE CARDIORRESPIRATORY SYSTEM
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pembrolizumab in Combination With R-ICE Chemotherapy in Relapsed/Refractory Diffuse Large B-cell Lymphoma
Status: RECRUITING
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: Pembrolizumab|DRUG: Rituximab|DRUG: Ifosfamide|DRUG: Carboplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HYPofractionated Adjuvant RadioTherapy in 1 Versus 2 Weeks in High-risk Patients With Breast Cancer (HYPART).
Status: RECRUITING
Conditions: Breast Cancer|Hypofractionation|Radiotherapy Side Effect
Interventions: RADIATION: 1 week RT|RADIATION: 2 week RT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Basiliximab in the Prevention of Acute Graft-versus-host Disease in Unrelated Allogeneic Hematopoietic Stem Cell Transplantation Therapy for Thalassemia Major
Status: UNKNOWN
Conditions: Beta-Thalassemia Major
Interventions: DRUG: Basiliximab,|DRUG: cyclosporine A|DRUG: Methotrexate|DRUG: Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Drinking Water PFAS, Pregnancy Outcome and Maternal Morbidity
Status: COMPLETED
Conditions: Birth Weight|Small for Gestational Age at Delivery|Large for Gestational Age at Delivery (Macrosomia)|Diabetes, Gestational|Hypertension in Pregnancy|Preeclampsia|Congenital Malformation
Interventions: OTHER: Per- and polyfluoroalkyl substances (PFAS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Protein Source, Nutrition Messaging, and Food Intake
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Whey Protein Beverage|DIETARY_SUPPLEMENT: Pea Protein Beverage|BEHAVIORAL: Snack Tray Choices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Oral GLP1RA RGT001-075 in Adults With Type 2 Diabetes
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: RGT001-075|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)
Status: RECRUITING
Conditions: Hematologic Malignancies|Inherited Disorders of Metabolism|Inherited Abnormalities of Platelets|Histiocytic Disorders|Acute Myelogenous Leukemia (AML or ANLL)|Acute Lymphoblastic Leukemia (ALL)|Other Acute Leukemia|Chronic Myelogenous Leukemia (CML)|Myelodysplastic (MDS) / Myeloproliferative (MPN) Diseases|Other Leukemia|Hodgkin Lymphoma|Non-hodgkin Lymphoma|Multiple Myeloma/ Plasma Cell Disorder (PCD)|Inherited Abnormalities of Erythrocyte Differentiation or Function|Disorders of the Immune System|Autoimmune Diseases|Severe Aplastic Anemia
Interventions: DRUG: A multicenter access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: NBTXR3 Crystalline Nanoparticles and Radiation Therapy in Treating Randomized Patients in Two Arms With Soft Tissue Sarcoma of the Extremity and Trunk Wall
Status: COMPLETED
Conditions: Adult Soft Tissue Sarcoma
Interventions: DEVICE: NBTXR3|DEVICE: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Yakult Ingestion in Residents and Staffs at Indonesian Elderly Houses
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Yakult®|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate Efficacy and Safety of Lenabasum in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Lenabasum 20 mg|DRUG: Lenabasum 5 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Balloon Angioplasty Versus Xpert Stent in CLI Patients XXS Study
Status: UNKNOWN
Conditions: Cronic Limb Ishemia|Intervention
Interventions: DEVICE: Balloon angioplasty|DEVICE: Use of self-expanding Expert stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Occlusal Bite Force Changes After Surgical Correction of the Increased Vertical Dimension
Status: COMPLETED
Conditions: Orthodontic Appliance
Interventions: PROCEDURE: Mandibular Setback with maxillary impaction|PROCEDURE: Mandibular setback only
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Hypoglycemia Associated Autonomic Failure
Status: UNKNOWN
Conditions: Diabetes Mellitus|Hypoglycemia|Autonomic Failure
Interventions: DRUG: naloxone|DIETARY_SUPPLEMENT: fructose|BEHAVIORAL: exercise|DRUG: Morphine sulfate|DRUG: Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Spine MRI in Patients With Deep Brain Stimulation (DBS)
Status: COMPLETED
Conditions: Parkinson Disease|Dystonia|Depression|Spinal Stenosis|Spinal Diseases
Interventions: DIAGNOSTIC_TEST: MRI of the spine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Optimal Growth of Preterm Infants With Growth Restriction
Status: WITHDRAWN
Conditions: Growth Failure|Adiposity|Diabetes|Neurologic Deficits
Interventions: DIETARY_SUPPLEMENT: SGA-enhanced nutrients|DIETARY_SUPPLEMENT: IUGR-enhanced nutrients|OTHER: SGA-standard nutrients|OTHER: IUGR-standard nutrients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study on the Whole-course Management (BCD-KPD-AutoHSCT) Scheme for Patients With RIMM
Status: RECRUITING
Conditions: Multiple Myeloma|Renal Injury
Interventions: DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Physostigmine-Enhanced Opioid Analgesia
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Physostigmine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of a Support Bra to Reduce Pain and Improve Surgical Healing in Women Undergoing Sternotomy for Cardiac Surgery
Status: UNKNOWN
Conditions: Pain|Disruption or Dehiscence of Closure of Sternum or Sternotomy|Quality of Life
Interventions: DEVICE: Adjustable Support Bra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Simultaneous Integrated Boost vs. Routine IMRT in Limited-stage Small-cell Lung Cancer
Status: UNKNOWN
Conditions: Small-cell Lung Cancer
Interventions: RADIATION: SIB-IMRT|RADIATION: routine IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualization of Ganciclovir and Valganciclovir Doses Using Bayesian Prediction in Renal Transplant Patients.
Status: COMPLETED
Conditions: Infection in Solid Organ Transplant Recipients
Interventions: DRUG: Ganciclovir/ Valganciclovir according to SPC|DRUG: Ganciclovir/ Valganciclovir according to PK model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yoga for Treatment of Overactive Bladder in Pediatric Patients
Status: RECRUITING
Conditions: Overactive Bladder|Overactive Bladder Syndrome|Overactive Detrusor
Interventions: BEHAVIORAL: Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Phase III Study Evaluating Efficacy and Safety of Canakinumab in Combination With Docetaxel in Adult Subjects With Non-small Cell Lung Cancers as a Second or Third Line Therapy
Status: TERMINATED
Conditions: Non-Small-Cell Lung
Interventions: DRUG: Canakinumab|DRUG: Docetaxel|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Home-based Transcutaneous Electrical Acustimulation for Treatment of Pain in Patients With Chronic Pancreatitis
Status: RECRUITING
Conditions: Chronic Pancreatitis
Interventions: DEVICE: Transcutaneous Electrical Acustimulation (TEA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3D US Guided Femoral Artery Access for TAVI
Status: UNKNOWN
Conditions: Ultrasound Therapy; Complications|Femoral Artery Injury
Interventions: DEVICE: 3D US|DEVICE: 2D US
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Deposition of Terbinafine After Iontophoretic Application of ETS Terbinafine Gel in Subjects With Distal Subungual Onychomycosis in the Great Toenail
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: Terbinafine HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnesium Oxide in Treating Postmenopausal Women With Hot Flashes and a History of Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Cancer Survivor|Hot Flashes
Interventions: DRUG: magnesium oxide|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Metabolic Impact of Bariatric Surgery Compared to Best Diabetic Care on Manitoba's Urban Indigenous Population
Status: UNKNOWN
Conditions: Type2 Diabetes Mellitus|Obesity|Bariatric Surgery Candidate
Interventions: PROCEDURE: Fast-Track to Bariatric Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Antimicrobial Efficacy and Adaptability of Bioceramic Sealer Containing Nanoparticles
Status: COMPLETED
Conditions: Endodontic Disease
Interventions: DRUG: bioceramic sealer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Soundscape on People With Dementia.
Status: COMPLETED
Conditions: Dementia|Behavioural and Psychiatric Symptoms of Dementia
Interventions: OTHER: Acusticare|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigation on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of a Long-acting GLP-1 Analogue in Healthy Male Subjects and Male Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2|Healthy
Interventions: DRUG: semaglutide|DRUG: semaglutide|DRUG: semaglutide|DRUG: placebo|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Fenofibrate And Microvascular Events in Type 1 Diabetes Eye.
Status: RECRUITING
Conditions: Type 1 Diabetes Mellitus|Diabetic Retinopathy|Diabetic Nephropathies
Interventions: DRUG: Fenofibrate|DRUG: Inert lactose placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Intraoperative Mechanical Ventilation Using EIT-titrated PEEP
Status: COMPLETED
Conditions: Pulmonary Atelectasis
Interventions: OTHER: Optimal PEEP|OTHER: Low PEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of ASLAN001 in Combination With Capecitabine in MBC That Has Failed on Prior Trastuzumab
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: ASLAN001|DRUG: Lapatinib|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Nu-V3 Non-Invasive Nerve Stimulation Device for Chronic Pain, Anxiety, Depression, Sleeplessness
Status: SUSPENDED
Conditions: Chronic Pain|Anxiety|Depression|Sleeplessness
Interventions: DEVICE: Nu-V3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Combination Spartalizumab and Canakinumab in Patients With Localized Clear Cell Renal Cell Carcinoma
Status: RECRUITING
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Spartalizumab|DRUG: Canakinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of New Tests for Gastrointestinal (GI) Permeability
Status: UNKNOWN
Conditions: Gastrointestinal Diseases
Interventions: DRUG: indometacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Creating a New Plan to Help the Indigenous People of Selangor Prepare for a Disease X Outbreak
Status: NOT_YET_RECRUITING
Conditions: Attitude to Health|Behavior, Health|Health Behavior|Health-Related Behavior|Health Attitude|Health Knowledge, Attitudes, Practice|Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: Outbreak Preparedness Intervention for the Orang Asli|BEHAVIORAL: Educational Brochures for the Orang Asli
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial on Acupuncture Therapy in Patients With Gastrointestinal Neoplasms Laparoscopic Surgery
Status: UNKNOWN
Conditions: Gastrointestinal Neoplasms
Interventions: PROCEDURE: Laparoscopic Surgery|DEVICE: Acupuncture treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electronic Medical Records to Increase Adherence to the Choosing Wisely Recommendations
Status: COMPLETED
Conditions: Dementia|Viral Infection|Vitamin D Deficiency
Interventions: BEHAVIORAL: Audit and Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Alcoholic-carrier Solutions Within Devices (HFA134a-MDI or Respimat®) on Breath Alcohol Measured by Ethylometer in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ethanolic Solution From HFA134a-MDI - low|DRUG: Ethanolic Solution From HFA134a-MDI - medium|DRUG: Ethanolic Solution From HFA134a-MDI - high|DRUG: Ethanolic Solution From Respimat®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide Versus Insulin Glargine in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec/liraglutide|DRUG: insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evolution of the SURvival of Patients With SEzary Syndrome (SS) Over the 1998-2020 Period and Its Association With the Early Use of Therapeutic Monoclonal Antibodies
Status: UNKNOWN
Conditions: Sezary Syndrome|Cutaneous T Lymphoma
Interventions: OTHER: Standard of care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: AZD0530 in Treating Patients With Extensive Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Extensive Stage Small Cell Lung Cancer|Lung Metastases|Malignant Pleural Effusion|Recurrent Small Cell Lung Cancer
Interventions: DRUG: saracatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetotherapy Versus Microwave Combined With Exercise for Knee Osteoarthritis.
Status: COMPLETED
Conditions: Knee Osteoarthritis|Pain
Interventions: DEVICE: Magnetotherapy plus exercise|DEVICE: Microwave plus exercise|DEVICE: Sham Magnetotherapy plus exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hepatitis C in Severe Mental Disorders: Nursing Programme
Status: UNKNOWN
Conditions: Hepatitis C|Severe Mental Disorder
Interventions: BEHAVIORAL: Nursing monitoring program|BEHAVIORAL: As usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Radiotherapy or Observation of Liver Metastases in Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Radiotherapy; Complications
Interventions: RADIATION: Radiotherpy will be performed to thoracic and liver metastasis after chemotherapy.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposome Bupivacaine for ANKLE Blocks
Status: COMPLETED
Conditions: Hallux Valgus (Bunions)
Interventions: DRUG: Liposome bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Study of Surufatinib Combined With Chidamide and Fulvestrant in HR Positive Unresectable Metastatic Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Breast Cancer Female
Interventions: DRUG: surufatinib + fulvestrant + chidamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter, Platform-type Clinical Study of Refractory/Recurrent Acute Myeloid Leukemia
Status: RECRUITING
Conditions: AML|Refractory|Relapsed
Interventions: DRUG: Ivosidenib,Venetoclax,gilteritinib,Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CGM Use in Poorly Controlled Youth With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes|Hypoglycemia|High Blood Sugar
Interventions: DEVICE: Dexcom G6 Continuous Glucose Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Platelet-Rich-Plasma in Spine Fusion
Status: UNKNOWN
Conditions: Platelet-Rich Plasma
Interventions: BIOLOGICAL: autologous platelet rich plasma|PROCEDURE: posteriolateral lumbar fusion only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HIPEC Combined Gastrectomy in Patients With Advanced Gastric Cancer Received Neoadjuvant Chemotherapy
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer|Peritoneal Metastases
Interventions: COMBINATION_PRODUCT: HIPEC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anesthesia for Loop Electrosurgical Excision Procedure (LEEP).
Status: COMPLETED
Conditions: Esketamine|Loop Electrosurgical Excision|Propofol
Interventions: DRUG: intravenous injection of propofol only|DRUG: intravenous injection of propofol +esketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Methadone for the Prevention of Postoperative Pain
Status: RECRUITING
Conditions: Orthopedic Surgery
Interventions: DRUG: Methadone Hydrochloride|DRUG: Sufentanil Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests
Status: COMPLETED
Conditions: Asthma|Cough Variant Asthma
Interventions: DRUG: high-dose methacholine challenge test|OTHER: mannitol challenge test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Intraoperative Magnesium on Remifentanil-induced Postoperative Hyperalgesia After Thyroidectomy
Status: COMPLETED
Conditions: Hyperalgesia
Interventions: DRUG: remifentanil, MgSO4
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: FK506 (Tacrolimus) in Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Placebo|DRUG: FK506 level < 2 ng/ml|DRUG: FK506 level 2-3 ng/ml|DRUG: FK506 level 3-5 ng/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Raised CBF During CEA on Cognition in DM Patients
Status: TERMINATED
Conditions: Carotid Artery Disease|Carotid Artery Stenosis|Diabetes|Cognitive Dysfunction
Interventions: PROCEDURE: Carotid endarterectomy|DEVICE: Shunt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of HYPNOsis Masks During Botulinum TOXin Injections in Idiopathic Overactive Bladder(HypnoTox)
Status: TERMINATED
Conditions: Idiopathic Overactive Bladder
Interventions: DEVICE: HyPNOS self-hypnosis mask from DREAMINZZ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study Using CABENUVA™ for the Treatment of Human Immunodeficiency Virus (HIV)-1, Administered in Infusion Centers (IC) or Alternate Sites of Administration (ASA) in the United States (U.S.)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: CABENUVA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Inhaled APN01 Developed as Treatment for COVID-19
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Angiotensin Converting Enzyme 2|DRUG: Sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Clinical Outcomes of intraVascular Ultrasound-guided vs Angiography-guided Primary pErcutaneous Intervention in Patients With Acute ST Segment Elevated Myocardial Infarction
Status: UNKNOWN
Conditions: ST Elevation Myocardial Infarction
Interventions: PROCEDURE: IVUS-guided PCI|PROCEDURE: Angiography-guided PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Clinical Trial of High-dose Rituximab (500mg/m²) Combined With CHOP Regimen in the Treatment of Male Patient With Newly Diagnosed Advanced DLBCL
Status: NOT_YET_RECRUITING
Conditions: Lymphoma, Large B-Cell, Diffuse
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial in Patients With Breast Cancer Susceptibility Gene (BRCA) Defective Tumours
Status: COMPLETED
Conditions: Breast Cancer|Ovarian Cancer
Interventions: DRUG: 6-Mercaptopurine|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parent Education and Choice About Newborn Screening and Bloodspot Retention
Status: COMPLETED
Conditions: Neonatal Screening
Interventions: BEHAVIORAL: Viewing Newborn Screening movie|BEHAVIORAL: Viewing Residual Dried Blood Spot movie
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: First in Human Trial of Topical VT30 in Pts With Venous/Lymphatic Malformations Assoc With PIK3CA or TEK Gene Mutations
Status: TERMINATED
Conditions: Venous Malformation|Lymphatic Malformation|Venolymphatic Malformation
Interventions: DRUG: VT30
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Tocilizumab Versus Corticosteroids in Hospitalised COVID-19 Patients With High Risk of Progression
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Tocilizumab|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antimicrobial Photodynamic Therapy Mediated by PapaMBlue® on Chronic Periodontal Disease
Status: UNKNOWN
Conditions: Periodontal Diseases
Interventions: PROCEDURE: Conventional treatment|RADIATION: aPDT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study of SYM-1219 Treatment of Women and Post-Menarchal Adolescent Girls With Bacterial Vaginosis
Status: COMPLETED
Conditions: Bacterial Vaginosis
Interventions: DRUG: SYM-1219|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mozobil for Autologous Stem Cell Mobilization
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma|Hodgkin's Lymphoma|Stem Cell Mobilization|Autologous Stem Cell Transplantation
Interventions: DRUG: Plerixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fosaprepitant Dimeglumine, Palonosetron Hydrochloride, and Dexamethasone in Preventing Nausea and Vomiting Caused by Cisplatin in Patients With Stage III or Stage IV Head and Neck Cancer Undergoing Chemotherapy and Radiation Therapy
Status: TERMINATED
Conditions: Nausea and Vomiting|Stage III Squamous Cell Carcinoma of the Hypopharynx|Stage III Squamous Cell Carcinoma of the Larynx|Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage III Squamous Cell Carcinoma of the Nasopharynx|Stage III Squamous Cell Carcinoma of the Oropharynx|Stage IV Squamous Cell Carcinoma of the Hypopharynx|Stage IV Squamous Cell Carcinoma of the Larynx|Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IV Squamous Cell Carcinoma of the Nasopharynx|Stage IV Squamous Cell Carcinoma of the Oropharynx
Interventions: DRUG: fosaprepitant dimeglumine|DRUG: cisplatin|DRUG: palonosetron hydrochloride|DRUG: dexamethasone|OTHER: Functional Living Index-Emesis Questionnaire|BEHAVIORAL: Emesis Diary|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SLOS: The Effect of Simvastatin in Patients Receiving Cholesterol Supplementation
Status: TERMINATED
Conditions: Smith-Lemli-Opitz Syndrome
Interventions: DRUG: Simvastatin|DIETARY_SUPPLEMENT: Lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Platelet Function in Minimal Extracorporeal Circulation in CABG
Status: COMPLETED
Conditions: Thrombocytopathy
Interventions: DEVICE: Mini extracorporeal circulation|DEVICE: Conventional extracorporeal circulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of IVIG Treatment on Critical Illness Polyneuropathy and/or Myopathy in Patients With MOF and SIRS/Sepsis
Status: TERMINATED
Conditions: Polyneuropathies
Interventions: DRUG: IgM-enriched Intravenous Immunoglobulins|DRUG: Human Albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Smoking Cessation Mobile Phone Program
Status: COMPLETED
Conditions: Nicotine Addiction|Drug Addiction|Drug Dependence|Substance Use Disorder|Tobacco Dependence
Interventions: DEVICE: Mobile Smoking Cessation Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Measure the Safety of Paliperidone ER (Extended-release) in Patients With Liver Disease
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Psychotic Disorders
Interventions: DRUG: Treatment as usual (TAU), Paliperidone ER
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OMEGA-3-Polyunsaturated Fatty-Acids (N3-Pufa) In Patients With Peripheral Arterial Disease
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DRUG: OMACOR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetic Study of Esomeprazole Magnesium in Patients 1 to 11 Years-Old With Endoscopically-Proven Gastroesophageal Reflux Disease (GERD)
Status: COMPLETED
Conditions: Endoscopically-Proven GERD|Reflux
Interventions: DRUG: esomeprazole magnesium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Lymphodepletion Plus Adoptive Cell Transfer With High Dose IL-2 in Patients With Metastatic Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Melanoma
Interventions: PROCEDURE: Surgery|DRUG: Administration of Lymphodepletion|OTHER: Adoptive Cell Transfer|DRUG: High Dose IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT