pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: ESD for Colorectal LSL Using a Selective Strategy - a Prospective Cohort Study
Status: RECRUITING
Conditions: Colorectal Neoplasm|Endoscopic Mucosal Resection
Interventions: PROCEDURE: Endoscopic Submucosal Dissection|PROCEDURE: Endoscopic Mucosal Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Knockdown of HSD17B13 mRNA, Pharmacokinetics, Safety, and Tolerability, of AZD7503 in Non-Alcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease|Fatty Liver, Nonalcoholic|NAFLD|Nonalcoholic Fatty Liver Disease|Nonalcoholic Steatohepatitis|NASH
Interventions: DRUG: AZD7503 Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Erlotinib and Avastin in Patients With Cancer of the Esophagus or Gastroesophageal Junction
Status: TERMINATED
Conditions: Esophageal Neoplasms|Esophageal Diseases
Interventions: DRUG: Erlotinib|DRUG: Avastin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Transcranial Magnetic Stimulation to Improve Hippocampal-dependent Declarative Memory Abilities
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Memory Loss
Interventions: DEVICE: Transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Partnering for Prevention: Building Healthy Habits in Underserved Communities
Status: COMPLETED
Conditions: Parenting|Child Nutrition Disorders
Interventions: BEHAVIORAL: Cooking Matters for Parents|BEHAVIORAL: Mealtime PREP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Observational Study Called FINEROD to Learn More About the Use of the Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions
Status: RECRUITING
Conditions: Chronic Kidney Disease|Type 2 Diabetes Mellitus
Interventions: DRUG: Finerenone (BAY 94-8862)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot Study to Test the Safety and Feasibility of a Brillouin Ocular Analyzer
Status: COMPLETED
Conditions: Measurement of the Elasticity of the Anterior Eye Segment
Interventions: DEVICE: Brillouin Ocular Analyser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Kidney Precision Medicine Project
Status: RECRUITING
Conditions: Acute Kidney Failure|Acute Kidney Insufficiency|Acute Renal Failure|Acute Renal Injury|Acute Renal Insufficiency|Kidney Failure, Acute|Kidney Insufficiency, Acute|Renal Failure, Acute|Renal Insufficiency, Acute|Chronic Kidney Diseases|Chronic Kidney Insufficiency|Chronic Renal Diseases|Chronic Renal Insufficiency|Kidney Insufficiency, Chronic
Interventions: PROCEDURE: Kidney Biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Calcium and Phosphorus Balance and Calcium Kinetics in Patients With Stage 3/4 Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DIETARY_SUPPLEMENT: 1500 mg/d elemental calcium as calcium carbonate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Grazoprevir (MK-5172) and Uprifosbuvir (MK-3682) With Elbasvir (MK-8742) or Ruzasvir (MK-8408) for Chronic Hepatitis C Genotype (GT)1 and GT2 Infection (MK-3682-011)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Grazoprevir|DRUG: Uprifosbuvir|DRUG: Elbasvir|DRUG: Ruzasvir|DRUG: Uprifosbuvir (+) Grazoprevir (+) Ruzasvir|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Negative Pressure Wound Therapy With Instillation for Treatment of Hidradenitis Suppurativa
Status: TERMINATED
Conditions: Hidradenitis Suppurativa
Interventions: PROCEDURE: Excision of HS followed by NPWTi|PROCEDURE: Excision of HS followed by NPWT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Efficacy of Saroglitazar Mg in Patients With Fasting Triglyceride ≥500 mg/dL and ≤1500 mg/dL
Status: SUSPENDED
Conditions: Dyslipidemias
Interventions: DRUG: Saroglitazar Magnesium 1 mg|DRUG: Saroglitazar Magnesium 2 mg|DRUG: Saroglitazar Magnesium 4 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Shoulder Exercises in Hypermobile Patients With Shoulder Symptoms
Status: COMPLETED
Conditions: Hypermobility Syndrome Shoulder|Shoulder Pain Chronic|Shoulder Luxation
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Virtual Reality for Lumbar Pain Management in an Outpatient Spine Clinic
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: COMBINATION_PRODUCT: Audiovisual Guided Relaxation|COMBINATION_PRODUCT: Virtual Reality Guided Relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of KHK7580 in Subjects With Secondary Hyperparathyroidism in Asia
Status: COMPLETED
Conditions: Secondary Hyperparathyroidism
Interventions: DRUG: KHK7580|DRUG: Cinacalcet Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Physical Activity and Sedentary Behaviour in Patients With Inflammatory Bowel Disease
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases|Physical Activity|Sedentary Behavior|Feasibility Study
Interventions: BEHAVIORAL: Intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Using Cognitive-Behavioral Change and Mobile Technology to Improve RN Sleep and Fatigue
Status: ENROLLING_BY_INVITATION
Conditions: Occupational Health|Sleep|Fatigue|Nurse
Interventions: BEHAVIORAL: RN-SLEEP|BEHAVIORAL: Healthy Habit - Educational Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Calcium/Vitamin D, Biomarkers & Colon Polyp Prevention
Status: COMPLETED
Conditions: Colorectal Adenomatous Polyps
Interventions: PROCEDURE: Rectal biopsy during colonoscopy|PROCEDURE: Rectal biopsy at randomization|PROCEDURE: Rectal biopsy at 1 year|PROCEDURE: Rectal biopsy prior to colonoscopy|PROCEDURE: Biopsies during colonoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Soybean Oil Trial of cArdiovascular Risk
Status: COMPLETED
Conditions: Cardiovascular Disease|Diabetes|Metabolic Syndrome
Interventions: OTHER: Soybean oil|OTHER: High-oleic soybean oil|OTHER: High-oleic soybean oil + fully hydrogenated soybean oil|OTHER: Palm olein + palm stearin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Metabolic Profile as a Predictor of No-reflow in Diabetic Patients
Status: UNKNOWN
Conditions: Acute Myocardial Infarction (AMI)
Interventions: OTHER: 1- LDL-C (low-density lipoprotein cholesterol)| and HDL-C(high-density lipoprotein cholesterol) Ratio. 2- Glycemia will be assessed : RBS ( random blood sugar ) . 3- S
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PrOgnostic imPlicaTIons of 2-diMensIonal Patterns for Residual Disease After Stenting CharacteriZEd by Quantitative Flow Ratio Pullback Curve Analysis
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: Quantitative Flow Ratio derived PPG and dQFR/ds
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase I Study of S-1 in Combination With Radiotherapy in Locally Advanced or Recurrent Gastric Cancer
Status: COMPLETED
Conditions: Gastrointestinal Neoplasms|Gastric Cancer
Interventions: DRUG: S-1|DRUG: S-1|DRUG: S-1|DRUG: S-1|DRUG: S-1|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the SafeR Mode in Patients With a Dual Chamber Pacemaker Indication
Status: COMPLETED
Conditions: Assess the Benefits From the AAISafeR/SafeR Algorithm of Symphony 2550 or REPLYTM DR in a Wide Range of Pacemaker Patients.
Interventions: DEVICE: Symphony DR 2550 and REPLY DR cardiac pacemakers|DEVICE: Symphony DR 2550 and REPLY DR cardiac pacemakers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Influence of Manual Relaxation of the Diaphragm on the Tension of the Posterior Superficial Fascia
Status: UNKNOWN
Conditions: Diaphragm; Relaxation|Low Back Pain
Interventions: PROCEDURE: Fascial release of diaphragm muscle.|PROCEDURE: Classic massage of the abdomen.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: In-Use Test of a Cosmetic Product in Subjects With Chronically Itchy Scalp
Status: COMPLETED
Conditions: Pruritus of the Scalp
Interventions: OTHER: WO 5101 Shampoo for Scalp and Hair
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety And Efficacy Of Sildenafil In Children With Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension|Hypertension, Pulmonary
Interventions: DRUG: Sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dietary Nitrate on Blood Pressure, Insulin Sensitivity, and Vascular Function in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Hypertension
Interventions: DIETARY_SUPPLEMENT: Beetroot juice|DIETARY_SUPPLEMENT: Nitrate depleted beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Progestin Priming Ovarian Stimulation (PPOS) Compared With Antagonist Protocol for Freeze-all Cycles
Status: TERMINATED
Conditions: Infertility
Interventions: DRUG: LH Suppression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coronally Advanced Flap in Combination With Acellular Dermal Matrix and Enamel Matrix Derivatives for Root Coverage
Status: COMPLETED
Conditions: Gingival Recession
Interventions: PROCEDURE: CAF+ADM+EMD|PROCEDURE: CAF+ADM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Trimodal Prehabilitation Strategy on Patients Undergoing Thoracoscopic Lobectomy
Status: COMPLETED
Conditions: Perioperative|Recovery|Prehabilitation|Thoracoschisis|Lung Cancer|Lobectomy
Interventions: BEHAVIORAL: Trimodal prehabilitation management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Immune Response and Liver Damage Induced by Chemotherapy for Liver Metastases of Colorectal Cancer
Status: UNKNOWN
Conditions: Resectable Hepatic Metastases of Colorectal Cancer
Interventions: PROCEDURE: Biopsie liver
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: Tracheal Intubation With the Rigid Tube for Laryngoscopy- a New Method
Status: COMPLETED
Conditions: Intubation;Difficult
Interventions: DEVICE: classical laryngoscopy|DEVICE: rigid tube for laryngoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Allogeneic Human Dermal Fibroblasts for Remodeling Scar Contractures
Status: TERMINATED
Conditions: Restrictive Scar Contracture|Restrictive Hypertrophic Scar|Burn Scar Contractures|Burn Scar
Interventions: DRUG: ICX-RHY-013
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Diagnostic Significance of Single Center, Open and Prospective Evaluation of <Sup>18<Sup>F-FDG PET/CT Dynamic Imaging and Genomic Sequencing in Detecting Metastatic Lesions of Primary Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Positron-Emission Tomography|Carcinoma, Hepatocellular
Interventions: DIAGNOSTIC_TEST: PET/CT dynamic scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Real World Insights During Treatment for Relapsed/Refractory Multiple Myeloma With Isatuximab
Status: RECRUITING
Conditions: Multiple Myeloma|Refractory Multiple Myeloma
Interventions: BEHAVIORAL: Digital Health Coaching Program|DEVICE: Fitbit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Trial of Cetuximab and Pemetrexed With Radiation in Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: Cetuximab|DRUG: Pemetrexed|PROCEDURE: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Hallucinogens and Other Drugs on Mood and Performance
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Hallucinogens and psychoactive substances
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: "Elastography" and "Tissue Harmonic Imaging" for Characterisation of Hilar and Mediastinal Lymph Nodes
Status: COMPLETED
Conditions: Lymphadenopathy
Interventions: OTHER: Procedure/Bronchoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treatment of Complex Anal Fistulas Using Centrifuged Adipose Tissue Containing Progenitor Cells
Status: COMPLETED
Conditions: Anal Fistula
Interventions: PROCEDURE: Autologous centrifuged adipose tissue (CAT) injection after anal fistulectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TA-65 Pharmacokinetic Study
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Dose A: TA-65 24mg, powder|DIETARY_SUPPLEMENT: Dose B: TA-65, 8mg, powder|DIETARY_SUPPLEMENT: Dose C: TA-65 3.2mg, capsule|DIETARY_SUPPLEMENT: Dose D: TA-65 8mg, capsule|DIETARY_SUPPLEMENT: Dose E: TA-65 32mg, capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Tolerance of URGO AWC_008 and URGO AWC_022 Dressings (EXPANSION)
Status: RECRUITING
Conditions: Diabetic Foot Ulcer|Venous Leg Ulcer|Pressure Ulcer|Wound Infection|Acute Wounds
Interventions: DEVICE: URGO AWC_008 dressing or URGO AWC_022 dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Acupuncture on Chemotherapy-Induced Peripheral Neuropathy (CIPN)
Status: UNKNOWN
Conditions: Chemotherapy-Induced Peripheral Neuropathy (CIPN)
Interventions: OTHER: acupuncture|OTHER: minimal acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Transcutaneous Electrical Nerve Stimulation (TENS) on Spasticity in Adult Patients With Spastic Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DEVICE: Transcutaneous Electrical Nerve Stimulation (TENS)|OTHER: Conventional physiotherapy treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vedolizumab Intravenous (IV) Compared to Placebo in Chinese Participants With Crohn's Disease.
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: Vedolizumab IV|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetic, and Pharmacodynamic Study of TS-142 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Step 1: TS-142|DRUG: Step 2: TS-142|DRUG: Step 2: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Macugen Treatment of Macular Edema Due to Branch Retinal Vein Occlusion
Status: COMPLETED
Conditions: Branch Retinal Vein Occlusion
Interventions: DRUG: pegaptanib sodium (Macugen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACVBP Plus Rituximab in Patients Aged From 18 to 59 Years With High-risk Diffuse Large B-cell Lymphoma
Status: COMPLETED
Conditions: Diffuse Large Cell Lymphoma
Interventions: DRUG: rituximab|DRUG: doxorubicin|DRUG: cyclophosphamide|PROCEDURE: autologous stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of MK-8237 Treatment in House-Dust-Mite Allergic Adolescents (MK-8237-008)
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial|Rhinitis, Allergic, Nonseasonal
Interventions: BIOLOGICAL: MK-8237 6 DU|BIOLOGICAL: MK-8237 12 DU|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine for Prevention of Chronic Postoperative Pain
Status: UNKNOWN
Conditions: Chronic Postoperative Pain
Interventions: DRUG: saline|DRUG: dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Strategies to Reduce Addiction Stigma Among Health Professionals
Status: COMPLETED
Conditions: Opioid Use Disorder|Substance Use Disorders|Stigma, Social
Interventions: BEHAVIORAL: Words Matter - Visual Campaign|BEHAVIORAL: Words Matter - Visual Campaign & Narrative Vignette (Messenger: Person with Opioid Use Disorder) Experimental: Words Matter - Visual Campaign & Narrative Vignette (Messenger: Clinician)|BEHAVIORAL: Words Matter - Visual Campaign & Narrative Vignette (Messenger: Clinician)|BEHAVIORAL: Words Matter - Visual Campaign & Narrative Vignette (Messenger: Health System Administrator)|BEHAVIORAL: Medication Treatment for Opioid Use Disorder Works - Visual Campaign|BEHAVIORAL: Medication Treatment for Opioid Use Disorder Works - Visual Campaign & Narrative Vignette (Messenger: Person with Opioid Use Disorder)|BEHAVIORAL: Medication Treatment for Opioid Use Disorder Works - Visual Campaign & Narrative Vignette (Messenger: Clinician)|BEHAVIORAL: Medication Treatment for Opioid Use Disorder Works - Visual Campaign & Narrative Vignette (Messenger: Health System Administrator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Hydroxychloroquine in Patients With X-linked Alport Syndrome in China (CHXLAS)
Status: RECRUITING
Conditions: Alport Syndrome, X-Linked
Interventions: DRUG: Hydroxychloroquine Sulfate 100 milligram (mg) Tab|DRUG: Benazepril hydrochloride 10 milligram (mg) Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Refractive Outcomes and Ocular Biometry of Two Swept-Source Optical Coherence Tomography-Based Biometers With Segmental or Equivalent Refractive Indices (ORION)
Status: RECRUITING
Conditions: Cataract
Interventions: DEVICE: IOLMaster 700 (Carl Zeiss Meditec AG)|DEVICE: Argos (Alcon Laboratories, Inc.)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Prospective, Randomized, Controlled, Clinical Study on Tolerability and Efficacy of hMG-IBSA
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: hMG-IBSA|PROCEDURE: Ovarian stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19: SARS-CoV-2 Detection in Saliva, Oropharyngeal and Nasopharyngeal Specimens
Status: COMPLETED
Conditions: SARS-CoV Infection|Covid19|Coronavirus
Interventions: DIAGNOSTIC_TEST: Sequence of testing.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Gemcitabine With or Without Combination Chemotherapy and Radiation Therapy in Treating Patients With Nonmetastatic Pancreatic Cancer That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: fluorouracil|DRUG: gemcitabine hydrochloride|DRUG: liposomal cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Saussurea Involucrata Liquid Tonic in Patient With Postpartum Rheumatism
Status: NOT_YET_RECRUITING
Conditions: Postpartum Rheumatism
Interventions: DRUG: Saussurea Involucrata Liquid Tonic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Intravenous Immunoglobulin (IVIg) in Patients With Subacute Proximal Diabetic Neuropathy
Status: TERMINATED
Conditions: Diabetic Neuropathies
Interventions: DRUG: immune globulin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of Treatments to Prevent Dental Caries
Status: COMPLETED
Conditions: Dental Caries
Interventions: DEVICE: Silver Diamine Fluoride|DEVICE: Fluoride Varnishes|DEVICE: Glass Ionomer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of QLS4131 in Patients With Recurrent or Refractory Multiple Myeloma
Status: NOT_YET_RECRUITING
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: DRUG: QLS4131 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Non-pharmacological Insomnia Therapy in People Living With HIV
Status: COMPLETED
Conditions: Insomnia|Sleep Efficiency
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Behavioral Modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness, Safety, and Tolerability Study of Oxymorphone Immediate Release (IR) Oral Liquid in Opioid Tolerant Pediatric Subjects
Status: WITHDRAWN
Conditions: Chronic Pain
Interventions: DRUG: oxymorphone IR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Elafibranor, PK and Safety in Children and Adolescents 8 to 17 Years of Age With Non Alcoholic Steatohepatitis (NASH)
Status: TERMINATED
Conditions: Non Alcoholic Steatohepatitis
Interventions: DRUG: Elafibranor 80mg|DRUG: Elafibranor 120mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: International Trial of Selumetinib in Combination With Dexamethasone for the Treatment of Acute Lymphoblastic Leukaemia
Status: TERMINATED
Conditions: Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia, Adult|Acute Lymphoblastic Leukemia, Pediatric|Acute Lymphoblastic Leukemia, in Relapse|Acute Lymphoblastic Leukemia Recurrent
Interventions: DRUG: Selumetinib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ipatasertib in Combination With Carboplatin, Carboplatin/Paclitaxel, or Capecitabine/Atezolizumab in Treating Patients With Metastatic Triple Negative Breast Cancer
Status: COMPLETED
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Triple-Negative Breast Carcinoma|Prognostic Stage IV Breast Cancer AJCC v8
Interventions: DRUG: Atezolizumab|DRUG: Capecitabine|DRUG: Carboplatin|DRUG: Ipatasertib|DRUG: Paclitaxel|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Assessment of Rheumatoid Arthritis Patients Who Changed Diet
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Overweight
Interventions: DIETARY_SUPPLEMENT: Whey Protein&Prebiotic Supplement|BEHAVIORAL: Dietary Counseling|BEHAVIORAL: Dietary recommendations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Phase I Clinical Trial of TQC2731 Injection
Status: UNKNOWN
Conditions: Asthma Severe Persistent Controlled
Interventions: DRUG: TQC2731|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SBRT/LDRT in Combination With Camrelizumab and Apatinib in Metastatic Non-small Cell Lung Cancer Patient Previously Treated With PD-1/L1 Inhibitor and Chemotherapy
Status: UNKNOWN
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Camrelizumab|DRUG: Apatinib|DRUG: Docetaxel injection|RADIATION: SBRT|RADIATION: LDRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CO2 (Carbon Dioxide) - Cerebral Oxygenation
Status: COMPLETED
Conditions: Hypoxia, Brain
Interventions: DRUG: Oxycarbon (5% CO2+ 95% O2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Internet-delivered Transdiagnostic Intervention for Anxiety and Depression
Status: UNKNOWN
Conditions: Depression|Dysthymic Disorder|Panic Disorder|Social Phobia|Specific Phobia|Obsessive-Compulsive Disorder|Generalized Anxiety Disorder
Interventions: BEHAVIORAL: Transdiagnostic program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk Factors of Neonatal Respiratory Distress for Newborns With Prenatally Diagnosed Congenital Lung Malformations
Status: COMPLETED
Conditions: Foetus With Congenital Pulmonary Malformation
Interventions: OTHER: identification of a pulmonary malformation in the fetus
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exercise and Repetitive Diving
Status: COMPLETED
Conditions: Decompression Sickness|Endothelial Dysfunction|Neutrophil Activation|Venous Gas Emboli
Interventions: OTHER: Aerobic running exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Low Dose Vasopressin in Traumatic Shock
Status: TERMINATED
Conditions: Injuries|Shock, Traumatic
Interventions: DRUG: normal saline control|DRUG: vasopressin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of the USASK Airway - An Improved Oral Airway for Bag-Mask Ventilation
Status: UNKNOWN
Conditions: Anesthesia, General
Interventions: DEVICE: Guedel airway|DEVICE: USASK airway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Mixture of Liposomal Bupivacaine and Bupivacaine for TAP Block for Open Hysterectomy
Status: COMPLETED
Conditions: Hysterectomy
Interventions: DRUG: Bupivacaine|DRUG: Liposomal bupivacaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety, Tolerability, and Bioequivalence of Orally Administered Venglustat in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Venglustat|DRUG: Venglustat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GTA-Glyceryltriacetate for Canavan Disease
Status: UNKNOWN
Conditions: Infantile Canavan Disease|Deficiency Disease, Aspartoacylase
Interventions: DRUG: GTA: Glyceryltriacetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addressing Nocturnal Sleep/Wake Effects on Risk of Suicide in Older Adults
Status: RECRUITING
Conditions: Sleep Initiation and Maintenance Disorders|Suicidal Ideation
Interventions: BEHAVIORAL: Digital Cognitive Behavioral Therapy for Insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Nalbuphine and Naloxone Administered as Nose Sprays in the Treatment of Orofacial Pain
Status: TERMINATED
Conditions: Temporomandibular Joint Dysfunction Syndrome|Burning Mouth Syndrome
Interventions: DRUG: nalbuphine plus naloxone|DRUG: nalbuphine plus placebo|DRUG: nalbuphine plus naloxone|DRUG: nalbuphine plus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Investigation of the Effectiveness of Tele-pulmonary Rehabilitation After Lung Resection
Status: NOT_YET_RECRUITING
Conditions: Tele-pulmonary Rehabilitation|Lung Cancer|Lung Resection
Interventions: OTHER: Rehabilitation group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Identification of Patients With a High Probability of Meeting Eligibility Criteria for an Alzheimer's Disease Clinical Trial (APHELEIA)
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer Disease|Mild Cognitive Impairment|Memory Loss|Memory Disorders|Memory Impairment
Interventions: OTHER: Prescreener database
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety of AMG 706 Plus Panitumumab Plus Gemcitabine-Cisplatin in the Treatment of Patients With Advanced Cancer
Status: TERMINATED
Conditions: Lung Cancer|Pancreatic Cancer|Esophageal Cancer
Interventions: DRUG: AMG 706|BIOLOGICAL: Panitumumab|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validate the Safety and Feasibility of the CT-guided Interventional Robot in Percutaneous Lung Cryablation Procedures
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer|Thoracic Cancer
Interventions: PROCEDURE: CT-fluoroscopy guided master-slave intervetional robot-assisted lung Cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ventripoint Single Ventricle Study
Status: RECRUITING
Conditions: Congenital Heart Disease|Single-ventricle
Interventions: DEVICE: Transthoracic Echocardiogram or Cardiac MRI|DEVICE: Ventripoint Echocardiogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cold Snare Polypectomy Versus Endoscopic Mucosal Resection for Colonic Sessile Serrated Polyps
Status: COMPLETED
Conditions: Colorectal Cancer|Adenoma
Interventions: PROCEDURE: Cold snare polypectomy|PROCEDURE: Endoscopic mucosal resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Research of Intensive Treatment in Hormone Receptor<10% and Human Epidermal Growth Factor Receptor-2 Negative Breast Cancer Patients With Positive Lymph Node Residual Disease After Neoadjuvant Chemotherapy
Status: RECRUITING
Conditions: Primary Breast Cancer
Interventions: DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Belimumab Administered in Combination With Rituximab to Adult Subjects With Systemic Lupus Erythematosus (SLE) - BLISS-BELIEVE
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Belimumab|DRUG: Rituximab|DRUG: Rituximab-placebo|DRUG: Standard therapy (Including Immunosuppressants)|DRUG: Standard therapy (Excluding Immunosuppressants)|DRUG: Steroid Taper
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Immune Response, the Safety and the Reactogenicity of Respiratory Syncytial Virus (RSV) Prefusion Protein 3 Older Adult (OA) (RSVPreF3 OA) Investigational Vaccine When co Administered With PCV20 in Older Adults
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: RSVPreF3 OA investigational vaccine|BIOLOGICAL: PCV20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cardiac Functions as a New Method for Evaluation of Fetal Anemia Pre and Post Intrauterine Fetal Blood Transfusion
Status: COMPLETED
Conditions: Fetal Anemia as Antepartum Condition (Diagnosis)|Rh Incompatible Blood Transfusion Nos
Interventions: RADIATION: Mid trimesteric fetal ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The INFLUENTIAL Trial- Evaluation of National Inpatient Influenza Vaccination Program
Status: NOT_YET_RECRUITING
Conditions: Influenza
Interventions: OTHER: Existing Influenza Vaccination Practices|OTHER: Standardized inpatient influenza vaccination program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of A Dental Application to Promote Self-Administered Plaque Control: A RCT
Status: COMPLETED
Conditions: Periodontitis|Gingivitis|Plaque, Dental
Interventions: OTHER: Mobile Dental Application, Dental Monitoring ("DM")
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Using Electrical Impedance Tomography to Investigate the Relationship Between Airflow Rate During High-flow Oxygen Therapy and Pressure in Patients With Heart Failure Compared to Non-invasive Ventilation
Status: ENROLLING_BY_INVITATION
Conditions: to Assess the Corresponding PEEP Values in NIV With CPAP Under Different Airflow Rates During HFOT in Heart Failure Patients
Interventions: DEVICE: Non-invasive ventilation (NIV) or high-flow oxygen therapy (HFOT) using electrical impedance tomography (EIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Haploidentical Hematopoietic Stem Cell Transplantation
Status: ACTIVE_NOT_RECRUITING
Conditions: Sickle Cell-thalassemia Disease|Thalassemia
Interventions: DRUG: peripheral blood stem cell graft that are CD34+ selected
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating an Ebola and a Marburg Vaccine in Uganda
Status: COMPLETED
Conditions: Ebola Virus Disease|Marburg Virus Disease
Interventions: BIOLOGICAL: Ebola vaccine|BIOLOGICAL: Marburg vaccine|OTHER: Placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Entecavir to Adefovir in Chronic Hepatitis B Virus (HBV) Patients With Hepatic Decompensation
Status: COMPLETED
Conditions: Hepatitis B
Interventions: DRUG: Entecavir (ETV)|DRUG: Adefovir (ADV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Classifying Ectopia Lentis in Marfan Syndrome Into Five Grades of Increasing Severity
Status: COMPLETED
Conditions: Marfan Syndrome|Ectopia Lentis
Interventions: OTHER: ophthalmological examinations using a slit lamp bio microscopy and a three-mirror lens, standard procedure.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Parastomal Reinforcement With Strattice
Status: COMPLETED
Conditions: Parastomal Hernia
Interventions: DEVICE: Strattice Reconstructive Matrix|OTHER: Standard ostomy creation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Rituximab Plus Beta-Glucan in Chronic Lymphocytic Leukemia(CLL)/Small Lymphocytic Lymphoma (SLL)
Status: TERMINATED
Conditions: Leukemia, Lymphocytic, Chronic|Lymphoma, Small Lymphocytic
Interventions: DRUG: Rituximab|DIETARY_SUPPLEMENT: Beta-Glucan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Prevent Anal Cancer Self-Swab Study
Status: COMPLETED
Conditions: Anal Cancer
Interventions: BEHAVIORAL: Home-based human papillomavirus (HPV) DNA screening|BEHAVIORAL: Clinic-based human papillomavirus (HPV) DNA screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study of Docetaxel in Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: epidoxorubicine, ciclophosphamide, methotrexate, fluorouracile|DRUG: epidoxorubicine, docetaxel, ciclophosphamide, methotrexate, fluorouracile|DRUG: epidoxorubicine, docetaxel, cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients
Status: UNKNOWN
Conditions: Anemia|Atherosclerosis|End-Stage Renal Disease|Oxidative Stress|Pro-Inflammation
Interventions: DRUG: acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Nattokinase on Inflammation and Cardiovascular Risk Markers in Patients With Dyslipidemia
Status: NOT_YET_RECRUITING
Conditions: Cardiovascular Diseases|Dyslipidemias|Inflammation
Interventions: DIETARY_SUPPLEMENT: Nattokinase|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: the Effect of Retrolaminar Block on Postoperative Pain
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: OTHER: retrolaminar block tecnique
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Evaluating the Safety, Tolerability, and Pharmacokinetics of Monoclonal Antibodies in Healthy Participants
Status: SUSPENDED
Conditions: HIV Infections
Interventions: BIOLOGICAL: VRC01.23LS|BIOLOGICAL: PGT121.414.LS|BIOLOGICAL: PGDM1400LS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Efficacy and Safety of CRC01 in Adult Large B-cell Lymphoma Patients
Status: RECRUITING
Conditions: Relapsed Large B-cell Lymphoma|Refractory Large B-cell Lymphoma|Diffuse Large B-cell Lymphoma (DLBCL)|Primary Mediastinal Large B-Cell Lymphoma (PMBCL)|High-grade B-cell Lymphoma|Transformed Follicular Lymphoma (TFL)
Interventions: BIOLOGICAL: CRC01|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Pharmacokinetics of Levodopa Following Administration of CVT 301 (Levodopa Inhalation Powder) in Adults With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: CVT-301 (levodopa inhalation powder)|DRUG: Carbidopa|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Ovarian Function After Hysterectomy With or Without Fimbriectomy or Salpingectomy
Status: UNKNOWN
Conditions: Ovarian Function Insufficiency
Interventions: PROCEDURE: Salpingectomy or Fimbriectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: PET (Positron Emission Tomography)/Public Speaking Study With A Combination Of 2 Medications In Social Anxiety Patients
Status: COMPLETED
Conditions: Depressive Disorder and Anxiety Disorders
Interventions: DRUG: vestipitant|DRUG: paroxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Community Based Strategies to Reduce Maternal Mortality in Northern Nigeria
Status: COMPLETED
Conditions: Maternal Mortality
Interventions: BEHAVIORAL: Voluntary Health Worker (VHW) Program|BEHAVIORAL: Safe Birth Kit|BEHAVIORAL: Community Folk Media Campaigns
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bone Marrow Stem Cell Infusion Following a Heart Attack
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Autologous, Unfractionated Bone Marrow Mononuclear Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Gene-Activated Bone Substitute "Histograft" for Lumbar and Cervical Spinal Fusion
Status: RECRUITING
Conditions: Cervical Disc Disorder With Radiculopathy|Spinal Stenosis|Lumbar and Other Intervertebral Disc Disorders With Radiculopathy|Biomechanical Lesion, Unspecified
Interventions: COMBINATION_PRODUCT: Osteoplastic material based on octacalcium phosphate and biologically active nucleic acids for bone tissue regeneration Nucleostim-VEGF ("Histograft")|OTHER: Synthetic osteoplastic material based on β-TCP or bone autograft
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation Of BW430C (Lamotrigine) Versus Placebo In The Prevention Of Mood Episodes In Bipolar I Disorder Patients
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: lamotrigine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Function After CPAP Therapy in Patients With Chronic Heart Failure and Sleep Apnea. A Multicenter Study
Status: TERMINATED
Conditions: Sleep Apnea|Heart Failure|Cardiovascular Diseases
Interventions: DEVICE: CPAP(Continuous Positive Airway Pressure)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Antiviral Activity and Safety of HH-003 in Chronic Hepatitis B Subjects With Low-level Viremia
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic HBV Infection
Interventions: DRUG: Nucleoside/nucleotide reverse transcriptase inhibitors (NrtIs)|DRUG: HH-003 and NrtIs|DRUG: HH-003, NrtIs and PEG-IFN-α
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study to Evaluate PK, Safety, and Tolerability of HRS-5041 in Healthy Caucasian Male Participants
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: HRS-5041 dose level 1|DRUG: HRS-5041 dose level 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT