pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Family-centered Perioperative Care for Anesthesia (FPCA) on Incidence of Emergency Delirium and Postoperative Maladaptive Behaviors in Children After Surgery
Status: NOT_YET_RECRUITING
Conditions: Postoperative Complications|Child|Anesthesia|Family
Interventions: OTHER: family-focused anesthesia strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Melatonin on Ischemia-reperfusion Injury Following Acute Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction|Ischemia-reperfusion Injury
Interventions: DRUG: Melatonin, N-acetyl-5-methoxytryptamine|DRUG: Isotonic saline, Natrium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ramucirumab and Carbo-Paclitaxel for Untreated Thymic Carcinoma / B3 Thymoma With Carcinoma (RELEVENT)
Status: ACTIVE_NOT_RECRUITING
Conditions: Thymic Carcinoma|Thymoma
Interventions: COMBINATION_PRODUCT: Ramucirumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Follow-up Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (Japan Study)
Status: COMPLETED
Conditions: Primary Immune Deficiency Disorder
Interventions: BIOLOGICAL: Immune globulin subcutaneous (Human)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers of Lung Injury in Hyperinflation in the Mechanical Ventilator Versus Manual Hyperinflation
Status: UNKNOWN
Conditions: Sepsis
Interventions: DEVICE: Hyperinflation with mechanical ventilator|DEVICE: Manual hyperinflation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety of Cultured Autologous Adult Adipose Derived Mesenchymal Stem Cell Intravenous Infusion for CP
Status: SUSPENDED
Conditions: Cerebral Palsy
Interventions: BIOLOGICAL: autologous adipose derived mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Level Laser Therapy in Muscle Fatigue and Muscle Recovery
Status: COMPLETED
Conditions: Muscle; Fatigue, Heart|Skeletal Muscle Recovery
Interventions: DEVICE: Low Level Laser (LLL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: EndoArt® Implantation in Subjects With Chronic Corneal Edema
Status: COMPLETED
Conditions: Corneal Edema
Interventions: DEVICE: THE ENDOART® IMPLANTATION (Artificial Endothelial layer)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase I Study to Evaluate Safety, Pharmacokinetics and Pharmacodynamics of GSK2256098 in Healthy Volunteers
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: GSK2256098|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Posterior Cervical Fixation Study
Status: ENROLLING_BY_INVITATION
Conditions: Degenerative Disc Disease|Craniocervical Injuries|Cervical Radiculopathy|Cervical Disc Disease|Cervical Fusion|Cervical Spine Disease|Cervical Myelopathy|Cervical Instabilities Spine|Thoracic Injury
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Backward Masking Tasks to Decipher Impaired Input-Output Connections in MS @7T
Status: RECRUITING
Conditions: Difference in Regional Brain Activity
Interventions: DIAGNOSTIC_TEST: IRM multimodale a ultra-haute camp
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: SPRING: Safety, Efficacy, Pharmacokinetics of tipRanavir/r IN Race/Gender HIV+ Patients Randomized to TDM or SoC
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: tipranavir|DRUG: ritonavir|DRUG: Optimized Background Regimen (OBR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Docetaxel and Estramustine Phosphate for High Risk Localized Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Docetaxel|DRUG: Estramustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Evaluate the Efficacy, Safety and Pharmacokinetics of YL202 in Patients With BC
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced or Metastatic Breast Cancer
Interventions: DRUG: YL202 should be intravenously infused
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Long-Term Safety and Tolerability of Efgartigimod PH20 SC Administered Subcutaneously in Patients With Generalized Myasthenia Gravis
Status: ACTIVE_NOT_RECRUITING
Conditions: Generalized Myasthenia Gravis
Interventions: BIOLOGICAL: efgartigimod PH20 SC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PReventive cOlostomy vs Ileostomy in Low anTErior reCTal Resection
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: PROCEDURE: Low anterior resection with protective loop ileostomy|PROCEDURE: Low anterior resection with protective loop transverse colostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates
Status: UNKNOWN
Conditions: Anemia, Neonatal|Intracranial Hemorrhages|Necrotizing Enterocolitis|Respiratory Distress Syndrome, Newborn|Retinopathy of Prematurity|Bronchopulmonary Dysplasia
Interventions: BIOLOGICAL: Umbilical Cord Blood Infusion|BIOLOGICAL: Intravenous Infusion of Peripheral Blood or its Components
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Steady-state TPV/RTV on the Single-dose Pharmacokinetics of Rifabutin and the Effects of Single-dose Rifabutin on the Steady-state Pharmacokinetics of TPV in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tipranavir|DRUG: Ritonavir|DRUG: Rifabutin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Usability Assessment of Naloxone Administration by Untrained Community Members
Status: COMPLETED
Conditions: Harm Reduction|Opioid-use Disorder|Naloxone
Interventions: DEVICE: Nasal Spray Naloxone|DEVICE: Intramuscular Naloxone|DEVICE: Improvised Nasal Atomizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cranial Electrotherapy Stimulation on Anesthetics Consumption and Postoperative Pain
Status: UNKNOWN
Conditions: Opioid Use|Cytokine
Interventions: PROCEDURE: electrotherapy|DRUG: Opioid Anesthetics|PROCEDURE: colon cancer surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating ABI-H0731+ Entecavir vs Entecavir Alone for the Treatment of Viremic HBeAg-positive Participants With Chronic Hepatitis B Virus Infection (cHBV)
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: ABI-H0731|DRUG: SOC ETV|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Provent Treatment of Obstructive Sleep Apnea in Patients Who Are Non-compliant With CPAP
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DEVICE: Provent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Endonasal Polymeric Implant for Chronic Rhinosinusitis
Status: UNKNOWN
Conditions: Rhinosinusitis Chronic
Interventions: DRUG: Corticosteroid Topical|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarker Feedback on Health and Wellbeing and Exercise Adherence Following a 6 Month Weight Management Course
Status: COMPLETED
Conditions: Exercise Training|Biomarkers
Interventions: BIOLOGICAL: Cardiometabolic biomarkers
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Feasibility of a Youth-led NCD Risk Reduction Initiative in Selected Schools of Slums in Karachi, Pakistan: a Mixed-methods, pre-and Post-intervention Study
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus|Cardiovascular Diseases|Cancer|Lung Diseases
Interventions: BEHAVIORAL: Youth-led NCD risk reduction intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Role of Cigarette Smoking in Regulating Allergen-induced Early and Late Responses in Mild Asthmatics
Status: COMPLETED
Conditions: Asthma
Interventions: PROCEDURE: Allergen Challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Results of Arthroscopic Massive Rotator Cuff Tears Repair With or Without Using Long Head of Biceps Tendon
Status: ACTIVE_NOT_RECRUITING
Conditions: Rotator Cuff Tears
Interventions: PROCEDURE: Arthroscopic massive rotator cuff repair|PROCEDURE: Arthroscopic massive rotator cuff repair with superior capsular augmentation using the long head of biceps tendon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Nitrous Oxide During ED Incision and Drainage of Abscess
Status: TERMINATED
Conditions: Abscess
Interventions: DRUG: Nitrous Oxide|DRUG: Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Early PReserved SPONtaneous Breathing Activity in Mechanically Ventilated Patients With ARDS (PReSPON)
Status: UNKNOWN
Conditions: Respiratory Distress Syndrome, Adult
Interventions: PROCEDURE: spontaneous breathing activity during APRV|PROCEDURE: No spontaneous breathing activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Lot-consistency Clinical Trial of Live Attenuated Varicella Vaccine
Status: COMPLETED
Conditions: Varicella
Interventions: BIOLOGICAL: Vaccine manufactured at commercialized scale|BIOLOGICAL: Vaccine manufactured at trial-scale
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Spironolactone on Collagen Metabolism in Patients With Pulmonary Arterial Hypertension
Status: UNKNOWN
Conditions: Pulmonary Hypertension
Interventions: DRUG: Spironolactone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Axitinib and Avelumab in Treating Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma
Status: COMPLETED
Conditions: Metastatic Adenoid Cystic Carcinoma|Progressive Disease|Recurrent Adenoid Cystic Carcinoma
Interventions: DRUG: Avelumab|DRUG: Axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Trial to Assess the MIcrovascular Integrity and Left Ventricular Function Recovery After Clopidogrel or TicagrelOr Administration, in Patients With STEMI Treated With Thrombolysis - The 'MIRTOS' Study
Status: COMPLETED
Conditions: Myocardial Infarction|ST Segment Elevation Myocardial Infarction (STEMI)
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel|PROCEDURE: Percutaneous Coronary Intervention (PCI)|PROCEDURE: Coronary Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of EQU-001 in Healthy Volunteers
Status: COMPLETED
Conditions: Safety Issues
Interventions: DRUG: EQU-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative MRI and 5-ALA Guidance to Improve the Extent of Resection in Brain Tumor Surgery
Status: UNKNOWN
Conditions: Primary Malignant Neoplasm of Nervous System|Glioma|Glioblastoma|Metastasis
Interventions: PROCEDURE: Interventional arm|PROCEDURE: Control arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Double Plasma Molecular Adsorption System in Acute on Chronic Liver Failure Patients
Status: RECRUITING
Conditions: Acute-On-Chronic Liver Failure|Acute on Chronic Hepatic Failure
Interventions: DEVICE: DPMAS|OTHER: standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Photoacoustic Imaging of Skin Inflammatory Disorders With Machine Learning-assisted Scoring
Status: UNKNOWN
Conditions: Eczema|Psoriasis
Interventions: OTHER: Photoacoustic imaging and Confocal Raman spectroscopy measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Artificial Intelligence Identifying Polyps in Real-world Colonoscopy
Status: COMPLETED
Conditions: Sensitivity of the ADS in Identifying Polyps in Real-world Colonoscopy|Mean Number of Polyps Per Colonoscopy for Colonoscopists and Colonoscopists + ADS
Interventions: DEVICE: colonoscopy withdrawal with the ADS monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Therasphere® and Systemic Therapy for Patients With Hepatocellular Carcinoma That is High-risk
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Atezolizumab and Bevacizumab|DRUG: Y90 + TKI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phototherapy Combination With Topicals in Vitiligo
Status: UNKNOWN
Conditions: Vitiligo, Generalized
Interventions: COMBINATION_PRODUCT: Tacrolimus 0.1% ointment twice daily plus NBUVB 3 times weekly|COMBINATION_PRODUCT: Calcipotriol/Betamethasone ointment plus NBUVB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Acupuncture on Body Mass Index in Overweight and Obese Women With Polycystic Ovary Syndrome (PCOS )
Status: ACTIVE_NOT_RECRUITING
Conditions: PCOS|Overweight|Obesity
Interventions: OTHER: Active acupuncture|OTHER: Sham acupuncture|OTHER: Lifestyle management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Tenofovir Alafenamide (TAF) Versus Tenofovir Disoproxil Fumarate (TDF) in Participants With Chronic Hepatitis B Infection Who Are Positive for Hepatitis B e Antigen
Status: COMPLETED
Conditions: HBeAg-positive Chronic Hepatitis B
Interventions: DRUG: TAF|DRUG: TDF|DRUG: TAF Placebo|DRUG: TDF Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Performance of Currently Available traNscaTHEter Aortic Valve Platforms in Inoperable Patients With Pure Aortic regurgitatiON of a Native Valve. The PANTHEON International Project.
Status: UNKNOWN
Conditions: Aortic Regurgitation
Interventions: DEVICE: TAVR
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bladder Irrigation 0.05% Lidocaine Decreases Postoperative CRBD
Status: UNKNOWN
Conditions: Bladder Discomfort
Interventions: DRUG: 0.05% Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: EEG and ANI Guided Anesthesia and Quality of Recovery
Status: RECRUITING
Conditions: Laparoscopic Gynecological Surgery
Interventions: PROCEDURE: EEG-and-ANI-guided anesthesia|PROCEDURE: standard anesthesia|DRUG: Sevoflurane and remifentanil|DEVICE: EEG and ANI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First in Human Study of AL-611 in Healthy Volunteers and Patients With Hepatitis C Virus Infection
Status: TERMINATED
Conditions: Hepatitis C
Interventions: DRUG: AL-611|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Effectiveness of Vestibular Stimulation as a Coadjuvant Treatment in Major Depression
Status: COMPLETED
Conditions: Depression|Major Depression|Vestibular Disorders
Interventions: OTHER: vestibular stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Buprenorphine and Naloxone for the Treatment of Opiate Dependence - 1
Status: COMPLETED
Conditions: Heroin Dependence|Substance-Related Disorders
Interventions: DRUG: Buprenorphine/naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Utilising Lifemap to Investigate Malignant Arrhythmia Therapy
Status: UNKNOWN
Conditions: Ischemic Cardiomyopathy|Sudden Cardiac Death|Implantable Defibrillator User|Myocardial Infarction|Arrhythmias, Cardiac
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Safety and Preliminary Tolerability of Lyophilized Lucinactant in Adults With Coronavirus Disease 2019 (COVID-19)
Status: COMPLETED
Conditions: COVID-19|Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
Interventions: DRUG: Lucinactant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PONAZA : A COMBINATION OF PONATINIB AND 5-AZACITIDINE IN CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE OR IN MYELOID BLAST CRISIS
Status: RECRUITING
Conditions: CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE|CHRONIC MYELOGENOUS LEUKAEMIA IN MYELOID BLAST CRISIS
Interventions: DRUG: Ponatinib|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Food Effect Study on Pharmacodynamic and Bioavailability of Clopidogrel 300/75 mg in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: clopidogrel|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Premedication With Simethicone or Simethicone Plus N-acetylcysteine in Improving Visibility During Upper Endoscopy
Status: COMPLETED
Conditions: Stomach Neoplasms
Interventions: DRUG: Water (Placebo)|DRUG: Simethicone|DRUG: N-acetylcysteine 500 mg|DRUG: N-acetylcysteine 1000 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Levocetirizine 5 mg: Reduction of Symptoms, Airway Resistance and Sleep Impairment in Persistent Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Levocetirizine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bortezomib in Treating Patients With Metastatic Thyroid Cancer That Did Not Respond to Radioactive Iodine Therapy
Status: COMPLETED
Conditions: Insular Thyroid Cancer|Recurrent Thyroid Cancer|Stage II Follicular Thyroid Cancer|Stage II Papillary Thyroid Cancer|Stage IV Follicular Thyroid Cancer|Stage IV Papillary Thyroid Cancer
Interventions: DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of External Leg Compression Devices on Healing and Blood Clotting
Status: ENROLLING_BY_INVITATION
Conditions: Venous Stasis|Deep Venous Thrombosis|Healing Wound
Interventions: DEVICE: Intermittent Pneumatic Compression, Rapid|DEVICE: Intermittent Pneumatic Compression, Slow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Third Trimester 3D Printed Models Versus 3D Ultrasound Effects on Maternal-Fetal Attachment
Status: COMPLETED
Conditions: Maternal-Fetal Relations
Interventions: OTHER: 3D printed model|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prophylatic Effect Preoperative Antibiotics With Mechanical Bowel Preparation in SSIs
Status: COMPLETED
Conditions: Surgical Site Infection|Postoperative Complications|Bowel Preparation|Oral Antibiotics|Colorectal Cancer
Interventions: DRUG: Neomycin,metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment of Three Basic Progressive Lens Designs
Status: COMPLETED
Conditions: Presbyopia
Interventions: DEVICE: Progressive Additional Lenses (PAL), pre calibrated and made of polymeric material with anti-reflection coating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Visual Assessment of DAILIES® AquaComfort Plus® for Astigmatism as Compared to 1-DAY ACUVUE® MOIST® for Astigmatism
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: Nelfilcon A toric contact lenses|DEVICE: Etafilcon A toric contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ARO-ANG3 in Adults With Mixed Dyslipidemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Mixed Dyslipidemia
Interventions: DRUG: ARO-ANG3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of SAR156597 in Treating Diffuse Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis
Interventions: DRUG: SAR156597|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Brivanib in Chinese Patients With Previously Treated Advanced HCC
Status: COMPLETED
Conditions: Hepatocellular Carcinoma (HCC)
Interventions: DRUG: Brivanib 800 mg, QD|DRUG: Brivanib 400 mg, BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Homeostatic and Non-homeostatic Processing of Food Cues in Anorexia Nervosa
Status: COMPLETED
Conditions: Anorexia Nervosa|Healthy
Interventions: OTHER: Glucose|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial of Lenvatinib Plus PembrolizumAb in Recurrent Gynecological Clear Cell Adenocarcinomas (LARA)
Status: RECRUITING
Conditions: Adenocarcinomas|Recurrent Gynecological
Interventions: DRUG: pembrolizumab and lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cholecalciferol for Vitamin D in Adult Cystic Fibrosis (CF) Patients
Status: COMPLETED
Conditions: Cystic Fibrosis|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: 5000 IU of cholecalciferol|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TEL and Clam Shell Exercises Affect After ACL
Status: COMPLETED
Conditions: Knee Ligament Injury
Interventions: DEVICE: goniometer|OTHER: clamshells exercises|OTHER: traditional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MEK Inhibitor PD-0325901 Trial in Adolescents and Adults With NF1
Status: COMPLETED
Conditions: Neurofibromatosis Type 1 and Growing or Symptomatic, Inoperable PN
Interventions: DRUG: PD-0325901
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Caregiver Resource Room (CRR): Using Technology to Enhance Support for Dementia Family Caregivers
Status: NOT_YET_RECRUITING
Conditions: Caregiver Burden|Caregiver Burnout|Dementia
Interventions: BEHAVIORAL: CarePair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical-ultrasonographic Assessment of Pulmonary Emphysema
Status: NOT_YET_RECRUITING
Conditions: Emphysema|Pulmonary Emphysema
Interventions: DIAGNOSTIC_TEST: Relationship between lung ultrasound and computed tomographic scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Methotrexate, Tafasitamab, Lenalidomide and Rituximab in Patients With PCNSL
Status: NOT_YET_RECRUITING
Conditions: Non-Hodgkin Lymphoma
Interventions: DRUG: Tafasitamab|DRUG: Lenalidomide|DRUG: Rituximab|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pre- and Post- Coronary Artery Bypass Graft Implantation Disposed Application of Xenon
Status: COMPLETED
Conditions: Xenon|Sevoflurane|Anesthetics, Inhalation|Coronary Disease|Coronary Artery Bypass
Interventions: DRUG: Xenon|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Surgical Outcomes of Patients Treated With the Surgery First Approach and Aligners
Status: RECRUITING
Conditions: Malocclusion, Angle Class III
Interventions: PROCEDURE: Orthognathic Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acceptance and Commitment Group Therapy for Adolescents With a Range of Functional Somatic Syndromes
Status: COMPLETED
Conditions: Somatization Disorder|Somatoform Disorders
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy|OTHER: Enhanced Usual Care (EUC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reliability and Validity of Inline Dynamometry Study for Measuring Knee Extensor Torque
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injuries|Anterior Cruciate Ligament Rupture|Anterior Cruciate Ligament Tear
Interventions: OTHER: KForce Link
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Double-Blind Trial of a Probiotic Supplement to Reduce the Symptoms of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DIETARY_SUPPLEMENT: Probiotic Supplement|DIETARY_SUPPLEMENT: Identical-appearing Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Safety, Tolerability and Pharmacokinetics of Intravitreal Pegcetacoplan (APL-2) for Patients With Wet AMD
Status: COMPLETED
Conditions: Neovascular Age-Related Macular Degeneration
Interventions: DRUG: Pegcetacoplan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dacomitinib in Lung Cancer With Uncommon EGFR Mutations
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer Metastatic|EGF-R Positive Non-Small Cell Lung Cancer
Interventions: DRUG: Dacomitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Humoral Immunity Against SARS-CoV-2 in Liver Transplanted Patients After COVID-19 in Comparison With Immunocompetent Patients
Status: UNKNOWN
Conditions: Liver Transplant Infection|Covid19|Mortality|Immune Response
Interventions: DIAGNOSTIC_TEST: CLIA of IgG and IgM against SARS-Cov-2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Long-term Trial of ETC-1002 in Patients With Hyper-LDL Cholesterolemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Hyper-low-density Lipoprotein (LDL) Cholesterolemia
Interventions: DRUG: 180mg of ETC-1002(bempedoic acid)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paediatric Syncope in the Emergency Department
Status: RECRUITING
Conditions: Syncope, Vasovagal|Postural Orthostatic Tachycardia Syndrome|Orthostatic Intolerance
Interventions: BEHAVIORAL: Counterpressure Maneuvers|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Neiguan (P6 Point) Acupressure in Patients With Gastroesophageal Reflux Disease (GERD)
Status: UNKNOWN
Conditions: Gastroesophageal Reflux Disease
Interventions: DEVICE: Acupressure wristband|DEVICE: Sham wristband
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: MCS in Treating Lower Urinary Tract Symptoms (LUTS) Suggestive of Benign Prostatic Hyperplasia
Status: TERMINATED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: MCS|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Allicor on Patients After Revascularization Treatment During a Year
Status: NOT_YET_RECRUITING
Conditions: Atherosclerosis|Peripheral Arterial Disease
Interventions: DIETARY_SUPPLEMENT: Allicor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Necessity of Preoperative Empirical Antibiotic Use in Acute Cholecystitis
Status: UNKNOWN
Conditions: Cholecystitis, Acute
Interventions: PROCEDURE: Laparoscopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vision Stability and Preference for Soft Toric vs. Soft Spherical Contact Lenses
Status: COMPLETED
Conditions: Astigmatism|Myopia
Interventions: DEVICE: Test Contact lens|DEVICE: Control Contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Drug-Coated Balloon Angioplasty for the Treatment of Chronic Total Occlusions
Status: UNKNOWN
Conditions: Coronary Artery Disease|Coronary Occlusion|Percutaneous Coronary Intervention|Chronic Total Occlusion of Coronary Artery|Drug-Eluting Stents
Interventions: DRUG: aspirin, betaloc, atorvastatin, rosuvastatin, clopidogrel, ticagrelor|DEVICE: coronary wires. or coronary balloons|OTHER: drug-coated balloon|DEVICE: drug-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Direct Outreach to Expand Access to Naloxone in the Context of Standing Orders
Status: COMPLETED
Conditions: Opioid Abuse|Overdose|Risk Behavior
Interventions: BEHAVIORAL: Naloxone Navigator 1.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acupuncture for Mild Traumatic Brain Injury：A Functional Magnetic Resonance Imaging Study
Status: COMPLETED
Conditions: Acupuncture|Mild Traumatic Brain Injury|MRI
Interventions: OTHER: acupuncture|OTHER: sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Enzastaurin Plus Temozolomide During and Following Radiation Therapy in Patients With Newly Diagnosed Glioblastoma With or Without the Novel Genomic Biomarker, DGM1
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: Enzastaurin Hydrochloride|OTHER: Placebo|DRUG: Temozolomide|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ-54767414 (HuMax CD38) (Anti-CD38 Monoclonal Antibody) in Combination With Backbone Treatments for the Treatment of Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Daratumumab|DRUG: Velcade|DRUG: Pomalidomide|DRUG: Dexamethasone|DRUG: Melphalan|DRUG: Prednisone|DRUG: Thalidomide|DRUG: Diphenhydramine|DRUG: Acetaminophen|DRUG: Carfilzomib|DRUG: Lenalidomide|DRUG: Montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial Investigating the Effect of Salmon Bone Meal on Osteoarthritis Among Men and Women
Status: COMPLETED
Conditions: Osteoarthritis|Osteoarthritis, Knee|Osteoarthritis, Hip
Interventions: DIETARY_SUPPLEMENT: Hydrolyzed Collagen|OTHER: Placebo|DIETARY_SUPPLEMENT: CalGo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bone Marrow Derived Adult Stem Cells for Dilated Cardiomyopathy
Status: COMPLETED
Conditions: Dilated Cardiomyopathy
Interventions: DRUG: granulocyte colony stimulating factor (GCSF)|PROCEDURE: bone marrow mononuclear cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of CYH33 in Combination With Endocrine Therapy With or Without Palbociclib in Patients With HR+, HER2- Advanced Breast Cancer
Status: UNKNOWN
Conditions: Advanced Breast Cancer
Interventions: DRUG: CYH33|DRUG: Fulvestrant|DRUG: Letrozole|DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Exercise on Abdominal Obesity and Risk Factors for Cardiovascular Disease
Status: COMPLETED
Conditions: Obesity|Metabolic Syndrome|Cardiovascular Disease
Interventions: OTHER: Exercise: LVLI|OTHER: Exercise: HVLI|OTHER: Exercise: LVHI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Medium Chain Triglyceride Supplemented Diet on Cognitive Function and Brain Activation in Type 1 Diabetes.
Status: COMPLETED
Conditions: Hypo-unawareness|Type 1 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Medium chain triglycerides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega™ Left Atrial Appendage (LAA) Occluder in Patients With Non-Valvular Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Omega™ Left Atrial Appendage (LAA) Occluder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Analysis of Cisatracurium Consumption in Balanced Anesthesia With 1% Sevoflurane, and With Only Sevoflurane, Using a Closed-loop Computer Controlled System Infusion.
Status: COMPLETED
Conditions: Drug Interaction Potentiation
Interventions: DRUG: 1% Sevoflurane|DRUG: Propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Three Sutures With Different Absorption Rates for Lower Abdominal Incision
Status: RECRUITING
Conditions: Cicatrix
Interventions: DEVICE: WE-MBVMS using suture Vicryl (Polyglactin 910; Johnson & Johnson International, USA);|DEVICE: WE-MBVMS using suture PDS (polydioxanone; Johnson & Johnson International, USA)|DEVICE: WE-MBVMS using suture Ethibond (polyester; Johnson & Johnson International, USA）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane
Status: COMPLETED
Conditions: Anesthesia
Interventions: PROCEDURE: Isocapnic Hyperponea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Evaluation of ET-01 Transplantation in Subjects With Transfusion Dependent β-Thalassaemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Transfusion Dependent Beta-Thalassaemia
Interventions: BIOLOGICAL: ET-01
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Antibody Therapy for Relapsed Lymphoma and Chronic Lymphocytic Leukemia
Status: TERMINATED
Conditions: Diffuse Large B-Cell Lymphoma|Follicular Lymphoma|Chronic Lymphocytic Leukemia|Mantle Cell Lymphoma|Small Lymphocytic Lymphoma
Interventions: BIOLOGICAL: Apolizumab|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dual 64Cu-DOTATATE and 18F-FDG PET/CT Imaging of Patients With Neuroendocrine Neoplasms
Status: ENROLLING_BY_INVITATION
Conditions: GEP-NET|Neuroendocrine Tumors|Neuroendocrine Carcinoma|Neuroendocrine Carcinoma Metastatic
Interventions: DRUG: 18F-FDG|DRUG: 64Cu-Dotatate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Assess the Local Cutaneous and Ocular Tolerance of Three Developmental Facial Skin-care Formulations.
Status: COMPLETED
Conditions: Skin Care
Interventions: OTHER: Serum|OTHER: Lotion|OTHER: Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Nasal Breathing for Perfomance in Elite Athletes.
Status: COMPLETED
Conditions: Breathing, Mouth
Interventions: DRUG: Oxymetazoline, 0.05% Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long-Term Follow-up of Subjects With Fanconi Anaemia Subtype A Treated With ex Vivo Gene Therapy
Status: ENROLLING_BY_INVITATION
Conditions: Fanconi Anemia Complementation Group A|Fanconi Anemia
Interventions: OTHER: Safety and efficacy assessments
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A First-in-Human Study of LY2409021 in Healthy Participants and Participants With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo|DRUG: LY2409021
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fed Study of Metoprolol Tartrate Tablets 25 mg and Lopressor® 50 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Metoprolol Tartrate Tablets 25 mg|DRUG: Lopressor® Tablets 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Improving Patient-Centered Communication in Breast Cancer Through Patient and Provider Interventions
Status: RECRUITING
Conditions: Anatomic Stage 0 Breast Cancer AJCC v8|Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Prognostic Stage 0 Breast Cancer AJCC v8|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8
Interventions: OTHER: Decision Aid iCanDecide - ESE website|OTHER: Decision Aid iCanDecide - S website|PROCEDURE: Therapeutic Conventional Surgery|OTHER: Interview|OTHER: Training|OTHER: Media Intervention|OTHER: Best Practice|OTHER: Survey Administration|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Magnetic Resonance-guided High-Intensity Focused Ultrasound (MR-HIFU) Used for Mild Hyperthermia
Status: WITHDRAWN
Conditions: Healthy Participants|Pelvic Neoplasms|Soft-tissue Sarcoma|Bladder Cancer|Cervical Cancer|Rectal Cancer
Interventions: DEVICE: Magnetic Resonance-guided High-Intensity Focused Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Long-Term Extension Study of RoActemra/Actemra (Tocilizumab) in Patients With Juvenile Idiopathic Arthritis Who Completed WA19977 Core Study
Status: COMPLETED
Conditions: Juvenile Idiopathic Arthritis
Interventions: DRUG: tocilizumab [RoActemra/Actemra]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Versus Fentanyl Added to Levobupivacaine for Transversus Abdominis Plane (TAP) Block
Status: COMPLETED
Conditions: Transversus Abdominis Block
Interventions: DRUG: Levobupivacaine|DRUG: Dexmedetomidine Injection [Precedex]|DRUG: fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Utility of Mobile Based Patient Reported Outcome Measures in Patients With Acetabular Fractures: A Randomized Controlled Trial.
Status: UNKNOWN
Conditions: Acetabular Fracture|PROMs|Mobile Phone Use
Interventions: OTHER: Mobile application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic Intervention After Surgical Removal of Mandibular Third Molars
Status: COMPLETED
Conditions: Surgery--Complications|Molar, Third
Interventions: DIETARY_SUPPLEMENT: Probiotic AB-DENTALAC|OTHER: Placebo|PROCEDURE: Surgical removal of mandibular third molars at baseline|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Emotions Immunology and Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Triple Negative Breast Cancer|Emotions|Immunology
Interventions: BEHAVIORAL: Standard of Care + Experimental Individualized Therapy|OTHER: Control: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Postoperative Pain of Rotary Versus Reciprocating Motions of Two Single Files
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DEVICE: OneSahpe single file|DEVICE: WaveOne Gold single file
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT