pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study to Compare the Safety and Pharmacokinetics of PK101 With Coadministration of the Two Separate Drugs
Status: COMPLETED
Conditions: Arthritis
Interventions: COMBINATION_PRODUCT: PK101|DRUG: PK101-001, PK101-002
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Safety of Umbilical Cord Blood Transfusion in the Treatment of Neonatal Cerebral Ischemia and Anemia
Status: UNKNOWN
Conditions: Hypoxic-Ischemic Encephalopathy|Hypoxia Neonatal|Cerebral Ischemia of Newborn|Anemia, Neonatal
Interventions: BIOLOGICAL: autologous umbilical cord blood (UCB)|PROCEDURE: standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First In Human Study to Assess CiVi007 in Subjects With an Elevated LDL-Cholesterol Level
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: CiVi007|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Different External Clearance Markers - Mannitol and Iohexol for Measuring Glomerular Filtration Rate
Status: RECRUITING
Conditions: Acute Kidney Injury|Chronic Kidney Insufficiency
Interventions: DIAGNOSTIC_TEST: Comparison of two external marker substance for measuring glomerular filtration rate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CINRYZE for the Treatment of Hereditary Angioedema Attacks in Children Under the Age of 12
Status: COMPLETED
Conditions: Hereditary Angioedema (HAE)
Interventions: BIOLOGICAL: CINRYZE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Ondansetron in Obsessive-compulsive and Tic Disorders
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder|Tic Disorders|Tourette Syndrome
Interventions: DRUG: Ondansetron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Autologous Peripheral Blood Lymphocytes in the Treatment of Patients With CLL or SLL
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: BIOLOGICAL: IOV-2001|DRUG: Low dose IL-2|DRUG: High dose IL-2|DRUG: IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent Headaches
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: BIOLOGICAL: Botulinum Toxin Type A|OTHER: Placebo (saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IRAK4 Inhibition in Treatment of COVID-19 With ARDS (I-RAMIC)
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: PF-06650833|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the Propel Mini and Propel Nova Steroid-Eluting Sinus Implant in Frontal Sinus
Status: COMPLETED
Conditions: Chronic Sinusitis
Interventions: DEVICE: PROPEL Mini Sinus Implant.|PROCEDURE: Sinus Surgery alone|DEVICE: Propel Nova Sinus Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: N2-(1-carboxyethyl)-2'Deoxyguanosine (CEdG) a Potential Biomarker for Diabetes
Status: COMPLETED
Conditions: Diabetes
Interventions: OTHER: N2-(1-carboxyethyl)-2'deoxyguanosine (CEdG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The DIALOGUE Study: Swiss-Korean Billateral Collaboration
Status: RECRUITING
Conditions: Hereditary Cancer|Breast Cancer|Ovarian Cancer
Interventions: OTHER: Adapted Family Gene Toolkit|OTHER: Targeted intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Clinical Study to Investigate the Efficacy of Orally Administered SA001 in Patients With Primary Sjögren's Syndrome
Status: COMPLETED
Conditions: Primary Sjögren's Syndrome (pSS)
Interventions: DRUG: SA001 Low dose|DRUG: SA001 Mid dose|DRUG: SA001 High dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Image-Guided Biopsies in Identifying Mechanisms of Resistance in Participants With Metastatic Castration Resistant Prostate Cancer Undergoing Radioligand Therapy
Status: WITHDRAWN
Conditions: Castration-Resistant Prostate Carcinoma|Metastatic Prostate Carcinoma|Stage IV Prostate Cancer
Interventions: PROCEDURE: Image Guided Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: Anifrolumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Skin Microbiome and the Potential of a Topical Probiotic Cream for Atopic Dermatitis
Status: UNKNOWN
Conditions: Atopic Dermatitis
Interventions: OTHER: Topical cream with live probiotic bacteria|OTHER: Placebo cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Quality of Bier Block
Status: UNKNOWN
Conditions: Analgesia
Interventions: DRUG: Lidocaine|DRUG: Magnesium Sulphate|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Multimodal Analgesia With Acetaminophen vs. Narcotics Alone After Hip Arthroscopy
Status: COMPLETED
Conditions: Hip Arthroscopy
Interventions: DRUG: Acetaminophen|DRUG: Percocet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Of Suture Materials on Sectio Scars (COSMOSS)
Status: UNKNOWN
Conditions: Uterine Scar
Interventions: PROCEDURE: Uterine Closure with monofilament or polyfilament suture materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of HIV-Infected and Uninfected Pregnant Woman/Child Dyads in Gaborone, Botswana
Status: COMPLETED
Conditions: HIV|Insulin Sensitivity|Diabetes Mellitus
Interventions: DRUG: Zidovudine|DRUG: Nevirapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Acceptability of the Luna EMG Rehabilitation Robot on Motor Recovery of the Upper Limb in the Chronic Phase of Stroke
Status: RECRUITING
Conditions: Stroke
Interventions: DEVICE: LUNA-EMG Robot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Post-marketing Safety Study in Patients With Moderate Renal Insufficiency Who Receive Omniscan for Contrast-enhanced Magnetic Resonance Imaging (MRI)
Status: COMPLETED
Conditions: Chronic Kidney Disease|Renal Insufficiency
Interventions: DRUG: Omniscan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Dexpramipexole and Warfarin Drug Drug Interaction (DDI) Study
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Warfarin|DRUG: Dexpramipexole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Simvastatin on Cardiac Function
Status: COMPLETED
Conditions: Rheumatic Heart Disease|Congenital Heart Disease|Aneurysm|Heart Valve Disease
Interventions: DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Abatacept in Patients With Primary Sjögren's Syndrome
Status: COMPLETED
Conditions: Sjögren's Syndrome
Interventions: DRUG: Abatacept SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cadonilimab in Combination With Bevacizumab and FOLFOX Regimen for the First-Line Treatment of Advanced Unresectable MSS-Type, RAS-Mutated Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer|Microsatellite Stable Colorectal Carcinoma|RAS Mutation|Cadonilimab
Interventions: DRUG: Cadonilimab + bevacizumab + FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of the Nurse Visit on Observance of the Intake of Oral Carcinological Treatment in the Elderly
Status: TERMINATED
Conditions: Oncology, Gerontology
Interventions: OTHER: nursing visit|OTHER: no nursing visit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Microparticles in Cirrhosis and Portal Hypertension
Status: COMPLETED
Conditions: Liver Cirrhosis|Portal Hypertension
Interventions: OTHER: research on interactions between portal hypertension and microparticles
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: RAD 1501: A Trial of Virtual Cone Trigeminal Neuralgia Radiosurgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Trigeminal Neuralgia
Interventions: DEVICE: Unframed Virtual Cone|RADIATION: 80 Gy Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study on Rectal Cancer to Verify if Response After Chemo-radiotherapy Can be Predicted With a Particular Blood Test.
Status: TERMINATED
Conditions: Locally Advanced Rectal Cancer
Interventions: RADIATION: Neoadjuvant radiotherapy|DRUG: Neoadjuvant chemotherapy|PROCEDURE: Radical surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Serratus Plain Block Versus Paravertebral Block Versus Serratus Plain Block and Paravertebral Block for Postoperative Pain Following Thoracoscopic Surgery
Status: COMPLETED
Conditions: Anesthesia, Local|Pain, Postoperative
Interventions: DRUG: loco-regional anesthesia serratus plane bloc (Ropivacaine 2 mg/mL, 40 mL) and paravertebral placebo bloc (saline, 20 mL)|DRUG: Loco-regional anesthesia : paravertebral bloc (Ropivacaine 4 mg/mL, 20 mL) and serratus plane placebo bloc (saline, 40 mL)|DRUG: Loco-regional anesthesia : serratus plane bloc (Ropivacaine 1,3 mg/mL, 40 mL) and paravertebral bloc (Ropivacaine 1,3 mg/mL, 20 mL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Mineralized Plasmatic Matrix With and Without Collagen Membrane in Peri-implant Bone Regeneration
Status: COMPLETED
Conditions: Horizontal Alveolar Bone Defect|Alveolar Bone Loss
Interventions: BIOLOGICAL: mineralized plasmatic matrix with collagen membrane|BIOLOGICAL: mineralized plasmatic matrix (MPM) without collagen membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Duration of Protective Effect From Inhaled Ipratropium Bromide on Methacholine Airway Hyperresponsiveness
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: ipratropium bromide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Tailoring Varenicline to Individual Needs (TVIN Study)
Status: COMPLETED
Conditions: Tobacco Dependence|Smoking Cessation
Interventions: DRUG: Varenicline|DRUG: Placebo|DRUG: Varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PK of Melphalan During Treatment With Melflufen and Dexamethasone in Patients With RRMM and Impaired Renal Function
Status: TERMINATED
Conditions: Renal Impairment|Multiple Myeloma
Interventions: DRUG: Melflufen|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tiragolumab in Combination With Atezolizumab Compared With Placebo in Combination With Atezolizumab in Patients With Previously Untreated Locally Advanced Unresectable or Metastatic PD-L1-Selected Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Atezolizumab|DRUG: Tiragolumab|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Paroxetine-CR (Paxil-CR) in the Treatment of Patients With Fibromyalgia Syndrome
Status: COMPLETED
Conditions: Fibromyalgia Syndrome
Interventions: DRUG: Paroxetine CR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improved Strategies for Outpatient Opioid Detoxification
Status: COMPLETED
Conditions: Opioid Dependence
Interventions: DRUG: oral naltrexone|DRUG: Buprenorphine|DRUG: Vivitrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resistance Training to Individuals for Cognitive Impairment With Dementia
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Mild Dementia
Interventions: OTHER: One Resistance Training Set (Single Session)|OTHER: Three Resistance Training Sets (Single Session)|OTHER: One Resistance Training Set (8 Weeks)|OTHER: Three Resistance Training Sets (8 Weeks)|OTHER: Control (8 Weeks)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Investigate the Safety, Pharmacokinetics, and Immunogenicity of Subcutaneous MCAF5352A in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: MCAF5352A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Comparison Between One Versus More Than Six Months of Dual Antiplatelet Therapy After Biolimus A9-eluting Stent Implantation
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: BioFreedom with 1 month DAPT|DEVICE: BioMatrix or Ultimaster with 6 to 12 months DAPT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Kinesio Taping Techniques in COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Kinesio Taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Kinematic Real Time Feedback Used to Learn Manual Therapy on Peripherical Joints
Status: COMPLETED
Conditions: Musculoskeletal Diseases|Complication of Manipulation Procedure|Defective; Learning (Specific)
Interventions: DEVICE: Kinematic Real Time Feedback|OTHER: Traditional systems of manual therapy teaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pragmatic Randomized Control Trial of Telehealth vs Standard Care in Follow-up of Patients With Chronic Conditions
Status: COMPLETED
Conditions: Chronic Disease|Diabetes|Vascular Diseases|Chronic Lung Disease|Cancer|Psychiatric Disorder
Interventions: DEVICE: Telemedicine: tablet and possibly tools to perform measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A GLP-1 Receptor PET Imaging Substudy Within the VER-A-T1D Trial Investigating the Effects on Beta Cell Mass
Status: RECRUITING
Conditions: Diabetes Mellitus
Interventions: RADIATION: 68Ga-NODAGA-exendin-4 PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Preoperative Window of Endocrine Therapy Provides Information to Increase Compliance
Status: COMPLETED
Conditions: Newly Diagnosed Hormone Positive Clinical Stage 1 or 2 Breast Cancer
Interventions: DRUG: Tamoxifen|PROCEDURE: Breast cancer surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Mental Health Problems Among Persons Without Personal Housing in the Context of the COVID-19 Epidemic
Status: UNKNOWN
Conditions: Psychological Distress|Quality of Life|Psychosocial Intervention
Interventions: BEHAVIORAL: Psychological First Aid (PFA)|BEHAVIORAL: Care as Usual (CAU)|BEHAVIORAL: Doing What Matters in Times of Stress (DWM)|BEHAVIORAL: Problem Management Plus (PM+)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Direct and Cross Effects of Adaptation to Systemic Hyperthermia: Impact on Quality of Life, Neurohormonal and Psychophysiological Human Status
Status: COMPLETED
Conditions: Hypoxia, Altitude|Exercise Tolerance|Metabolic Disturbance|Quality of Life
Interventions: DEVICE: Hyperthermic Fitness Treatment (HFT)|DEVICE: Placebo Hyperthermic Fitness Treatment|OTHER: Physical Examination|OTHER: Assessment of Cardiorespiratory Fitness|OTHER: Autonomic Balance, Orthostatic and Hypoxic tolerance|OTHER: Psychological Testing|OTHER: Measurement of Blood Markers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Treatment With Viusid in Post-COVID-19 Syndrome
Status: COMPLETED
Conditions: Post-COVID-19 Syndrome|COVID-19|Dyspnea|Fatigue|Cough|Inflammation
Interventions: DIETARY_SUPPLEMENT: Viusid Oral Solution|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evidence-based Pediatric Obstructive Sleep Apnea Detection
Status: ENROLLING_BY_INVITATION
Conditions: Obstructive Sleep Apnea of Child
Interventions: BEHAVIORAL: Health Communication Message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Yoga for Adolescent Idiopathic Scoliosis (AIS) Patients
Status: NOT_YET_RECRUITING
Conditions: Adolescent Idiopathic Scoliosis|Spinal Fusion
Interventions: BEHAVIORAL: Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Explore the Relationship Between Heart Rate Variability, Body Mass Index, Inflammation, and Insulin Resistance.
Status: RECRUITING
Conditions: Obesity|Insulin Resistance|Overweight
Interventions: BEHAVIORAL: aerobic exercise(AE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Decision Aid on End-of-life Care for Patients With Advanced COPD and Their Family
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease Severe
Interventions: BEHAVIORAL: Decision Support Intervention|BEHAVIORAL: Health Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase I Study to Investigate Safety, Tolerability, and Pharmacokinetics of VVZ-149 Injection
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: VVZ-149 Injection|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Platelet Transfusion Therapy in Patients With Blood Cancer or Treatment-Induced Thrombocytopenia
Status: TERMINATED
Conditions: Acute Biphenotypic Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|B-Cell Non-Hodgkin Lymphoma|Chronic Lymphocytic Leukemia|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Hematologic and Lymphocytic Disorder|Hematopoietic Cell Transplantation Recipient|Myelodysplastic Syndrome|Primary Myelofibrosis|Secondary Myelofibrosis|T-Cell Non-Hodgkin Lymphoma|Thrombocytopenia|Venous Thromboembolism
Interventions: BIOLOGICAL: Platelet Transfusion|BIOLOGICAL: Platelet Transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Multimedia-based Hormonal Therapy Information Program for Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: OTHER: Multimedia-Based Hormone Therapy Information Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Antiplatelet Effects of Ticagrelor Versus Clopidogrel in American Indian Patients
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Histologic and Endoscopic Remission Induced by Infliximab in Moderate to Severe Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy of Maintenance Therapy Using Uracil-tegafur (UFT) or Bacille Calmette-Guerin (BCG) for the Prevention of Recurrences of Superficial Bladder Cancer (EMBARK Study)
Status: UNKNOWN
Conditions: Bladder Cancer
Interventions: DRUG: Bacille Calmette-Guerin|DRUG: uracil-tegafur
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TXA in Anticoagulated Patients Study
Status: TERMINATED
Conditions: Total Shoulder Athroplasty
Interventions: DRUG: Tranexamic Acid Injection (TXA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1b/2 Study of Combination 177Lu Girentuximab Plus Cabozantinib and Nivolumab in Treatment naïve Patients With Advanced Clear Cell RCC
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Cancer|Clear Cell Renal Cell Carcinoma
Interventions: DRUG: 177Lu girentuximab|DRUG: Nivolumab|DRUG: Cabozantinib|DRUG: ArabinoFuranosylGuanine [18F]F-AraG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Acupuncture, BioModulator, and Transcutaneous Electrical Nerve Stimulation for Symptomatic Treatment of Chronic Pain.
Status: COMPLETED
Conditions: Chronic Pain|Depression|PTSD Symptoms|Sleep
Interventions: OTHER: Traditional Chinese Acupuncture|DEVICE: Tennant™ Biomodulator Treatment|DEVICE: Transcutaneous electrical nerve stimulation (TENS) Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimizing Narcotic Analgesics After Endocrine Surgery
Status: COMPLETED
Conditions: Thyroid Cancer|Thyroid Nodule|Thyroid Neoplasms|Thyroid Goitre|Thyroid Diseases|Parathyroid Diseases|Parathyroid Adenoma|Parathyroid Hyperplasia
Interventions: DRUG: Acetaminophen 500Mg Cap|DRUG: Tylenol #3 Oral Tablet|DRUG: Tramadol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Characterization and Sequential Pharmacotherapy of Severe Mood Dysregulation
Status: COMPLETED
Conditions: Severe Mood Dysregulation
Interventions: DRUG: lisdexamfetamine|DRUG: Placebo|DRUG: fluoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of a Twice Daily Versus a Three Times Daily Insulin Regimen in Children With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Detemir|OTHER: Novolin NPH or Humulin N
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Food Pantry Client and Staff Preferences for Nutritious no Prep Ready-to-eat Meals
Status: COMPLETED
Conditions: Diet, Healthy|Food Security
Interventions: BEHAVIORAL: No prep ready-to-eat meals|BEHAVIORAL: Ingredient bundles (e.g. meal kits)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness and Safety of 3 Dosing Regimens of CP-690,550 to Placebo in Subjects With Moderate to Severe Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: CP-690,550|DRUG: CP-690,550|DRUG: CP-690,550|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Versus Midazolam for Continuous Sedation in the Intensive Care Unit (ICU)
Status: COMPLETED
Conditions: Continuous Sedation in Initially Sedated Adults in ICU
Interventions: DRUG: Dexmedetomidine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Efficacy and Safety of PF-06947386 in Japanese Adult Patients With Complicated Intra-abdominal Infection
Status: COMPLETED
Conditions: Complicated Intra-abdominal Infection
Interventions: DRUG: PF-06947386|DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid Use for Bleeding Prevention in the Surgical Treatment of Metastatic Spinal Tumor in Lung Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Metastasis Spinal Tumor
Interventions: DRUG: Tranexamic Acid|DRUG: stroke-physiological saline solution (SPSS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Zanubrutinib, Lenalidomide Plus R-CHOP as the First-line Treatment for Diffused Large B-cell Lymphoma
Status: RECRUITING
Conditions: Non Hodgkin Lymphoma|Diffuse Large B Cell Lymphoma
Interventions: DRUG: Zanubrutinib|DRUG: Lenalidomide|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone (or equivalent)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serum Anti-mullerian Hormone and Polycystic Ovarian Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: PROCEDURE: Laparoscopic ovarian drilling|BIOLOGICAL: Antimullerian hormone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Targeting Anhedonia in Cocaine Use Disorder
Status: COMPLETED
Conditions: Cocaine-Related Disorders|Anhedonia
Interventions: DRUG: d-amphetamine|BEHAVIORAL: Contingency management|DRUG: Placebo (for d-amphetamine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effects of Gabapentin After Scoliosis Surgery in Children
Status: COMPLETED
Conditions: Scoliosis
Interventions: DRUG: Gabapentin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of ProVetus/Sponsorship Initiative
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder|Reintegration|Social Support
Interventions: BEHAVIORAL: Pro Vetus|BEHAVIORAL: Team Red, White, and Blue (TM RWB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Measurement and Characterization of Circulating Endothelial Cells or Circulating Tumor Cells or Circulating DNA in Adult Patients With Metastatic Cancer
Status: UNKNOWN
Conditions: Metastatic Cancer
Interventions: PROCEDURE: Blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cognitive Enhancement in Depression (The COG-D Study)
Status: RECRUITING
Conditions: Aging|Depression|Cognitive Symptom
Interventions: BEHAVIORAL: Cognitive Training|DEVICE: tDCS (active stimulation)|DEVICE: tDCS (sham stimulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy of Natural Killer(NK) Cells in Human T Lymphotropic Virus Type 1(HTLV-1) Associated Myelopathy(HAM)
Status: UNKNOWN
Conditions: HAM
Interventions: BIOLOGICAL: NK cells|BIOLOGICAL: amniotic epithelial cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peptide Receptor Radionuclide Therapy With 90Y-Dotatoc in Relapsed/Refractory Diffuse Large B Cell and Mantle Cell Lymphomas
Status: TERMINATED
Conditions: DLBCL|MCL|Recurrent Disease
Interventions: DRUG: 90Y-DOTATOC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trametinib in Treating Patients With Advanced Melanoma With BRAF Non-V600 Mutations
Status: COMPLETED
Conditions: Recurrent Melanoma|Stage IIIB Melanoma|Stage IIIC Melanoma|Stage IV Melanoma
Interventions: DRUG: trametinib|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proton Therapy With Chemotherapy for Stage III Non-Small Cell Lung Cancer (LU02)
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer
Interventions: RADIATION: PET positive nodal disease measuring 15 mm or greater|RADIATION: PET positive nodal disease measuring less than 15 mm|RADIATION: Patients considered resectable
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of PaQ™ (a Simple Patch on Insulin Delivery Device) in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DEVICE: PaQ™ insulin infusion device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Varenicline Treatment for Active Alcoholic Smokers
Status: COMPLETED
Conditions: Smoking|Tobacco Dependence|Alcohol Dependence
Interventions: DRUG: Varenicline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of IBRF Disorders of Consciousness Advanced Care/MultiModal Care Protocol in Severe Disorders of Consciousness
Status: UNKNOWN
Conditions: Brain Injury
Interventions: DRUG: Polypharmacy using FDA-approved products|DEVICE: Median Nerve Stimulation (MNS)|DIETARY_SUPPLEMENT: Nutraceutical Supplementation|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimization of IntraLipid Versus Omegaven
Status: UNKNOWN
Conditions: Cholestasis|Parenteral Nutrition Associated Liver Disease (PNALD)
Interventions: DIETARY_SUPPLEMENT: Omegaven|DIETARY_SUPPLEMENT: Lipid minimization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Necessity of Esophageal Dissection During Laparoscopic Fundoplication
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease|Hiatal Hernia
Interventions: PROCEDURE: Lap. Fundo. with Mobilization of the Esophageal Junction|PROCEDURE: Lap. Fundo. without Mobilization of the Esophageal Junction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Estimate the Effects of Hepatic Impairment on the Pharmacokinetics (PK) of PF-07321332
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: PF-07321332|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Relationship Between CETP Deficiency and Atherosclerosis in Patients With Hyperalphalipoproteinemia
Status: UNKNOWN
Conditions: Low CETP Activity|CETP Deficiency|Hyperalphalipoproteinemia|Hyper-LDL-cholesterolemia|High Level of Remnant Cholesterol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fasting Study of Metformin Hydrochloride ER Tablets 500 mg and Glucophage® XR Tablets 500 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Metformin Hydrochloride ER Tablets 500 mg|DRUG: Glucophage® XR Tablets 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Nocturnal Oxygen Needs and Central Sleep Apnea in Patients With Chronic Heart Failure.
Status: UNKNOWN
Conditions: Chronic Heart Failure|Central Sleep Apnea
Interventions: DEVICE: Titration of nocturnal oxygen needs to prevent desaturations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First In Human Study Evaluating the Safety and Performance of the "LapBox" Containment System for Laparoscopic Tissue Morcellation
Status: UNKNOWN
Conditions: Laparoscopic Surgical Procedure
Interventions: DEVICE: Laparoscopic Tissue Morcellation working space (bag)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effect of Mixed On-line Hemodiafiltration on Circulating Markers of Inflammation and Vascular Dysfunction
Status: COMPLETED
Conditions: Chronic Kidney Failure|Dialysis Related Complication
Interventions: PROCEDURE: mixed on-line hemodiafiltration|PROCEDURE: High flux bicarbonate dialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Safety and Efficacy Study of a Single or Double Dose of HEPLISAV™ Hepatitis B Vaccine in Adults With End-Stage Renal Disease
Status: TERMINATED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: 1018 ISS-HBsAg-Single|BIOLOGICAL: 1018 ISS-HBsAg-Double
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Primary Care Evidence-based Approach for Improving Lifelong Health
Status: NOT_YET_RECRUITING
Conditions: Clinical Trial
Interventions: BEHAVIORAL: SMS/Text (CAMPI)|BEHAVIORAL: Fidelity Monitoring System (Lyssn)|BEHAVIORAL: Family Check-Up 4 Health (FCU4Health)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety & Efficacy of a Single Dose of Sumatriptan Powder Delivered Intranasally With the Bi-directional Device in Adults With Acute Migraine
Status: COMPLETED
Conditions: Migraine Headache
Interventions: DRUG: Sumatriptan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: D,L-MEthadone and mFOLFOX6 in Treatment of Advanced Colorectal Cancer
Status: RECRUITING
Conditions: Chemo-refractory Colorectal Carcinoma
Interventions: DRUG: Maximum tolerated dose, MTD: D,L-methadone hydrochloride (Methasan® 10 mg/ml)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Occlusal Caries Management in First Permanent Molars in Child Dental Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Caries Pit and Fissure|Dental Caries in Children
Interventions: DRUG: Fluoride Varnishes|DRUG: Fissure Sealants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity of One Dose of a Surface, Antigen, Inactivated, Influenza Vaccine Produced in Mammalian Cell Culture Administered to Adult and Elderly Subjects
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: seasonal influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prophylaxis of Surgical Wound Infection With Topical Antibiotics
Status: RECRUITING
Conditions: Surgical Site Infection|Surgery--Complications|Colorectal Surgery|Cesarean Section; Infection|Hernia, Abdominal
Interventions: OTHER: Topical antibiotic prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Comparing a Disposable Flexible Cystoscope With Reusable Scopes in Adult Patients.
Status: NOT_YET_RECRUITING
Conditions: Bladder Cancer|Bladder Stone|Bladder Outlet Obstruction|Renal Stone|Renal Disease
Interventions: DEVICE: Cystoscopy with RedPine flexible disposable cystoscope|DEVICE: Cystoscopy with standard of care flexible reusable scope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Real-time Feedback in Swimming: Workout Compliance and Swimming Performance Outcomes Using Smart Swim Goggles
Status: COMPLETED
Conditions: Effect of Real-time Visual Feedback on Participant Compliance, Motivation, and Performance in Swimming
Interventions: OTHER: Real-time feedback using smart swim goggles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dopexamine and Norepinephrine Compared With Epinephrine Alone in Septic Shock
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: Dopexamine and norepinephrine|DRUG: Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Seltorexant|DRUG: Matching placebo to Seltorexant|DRUG: Quetiapine XR|DRUG: Matching placebo to Quetiapine XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Donor Human Milk Supplementation for the Treatment of Hypoglycemia in the Breastfed Infant
Status: COMPLETED
Conditions: Neonatal Hypoglycemia
Interventions: DIETARY_SUPPLEMENT: Bottle Supplementation--Commercially-Sterilized Donor Human Milk|DIETARY_SUPPLEMENT: Bottle Supplementation--Standard Infant Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety, Pharmacokinetics, and Preliminary Effect on Scar Formation by RXI-109
Status: COMPLETED
Conditions: Cicatrix|Scar Prevention
Interventions: DRUG: RXI-109|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Positive Emotional Processing: Exploring Novel Treatment Targets in Social Phobia
Status: COMPLETED
Conditions: Social Anxiety Disorder
Interventions: BEHAVIORAL: Approach-positive AAT|BEHAVIORAL: Control AAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of and Immune Response to a Dengue Virus Vaccine (rDEN3delta30/31-7164) in Healthy Adults
Status: COMPLETED
Conditions: Dengue Fever
Interventions: BIOLOGICAL: rDEN3delta30/31-7164
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Birth-Cohort Evaluation to Advance Screening and Testing for Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C|Chronic Hepatitis C
Interventions: OTHER: Mailer|OTHER: In-person recruitment|OTHER: EHR Alert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Does Vitamin C Reduce Finger Stiffness After Distal Radius Fractures?
Status: COMPLETED
Conditions: Finger Stiffness|Distal Radius Fracture
Interventions: DRUG: 500 mg vitamin c, 1 pill per day for 6 weeks|DRUG: 1 placebo pill for 6 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Transpapillary Stenting in the Treatment of Bile Leakage After Liver Transection.
Status: COMPLETED
Conditions: Bile Leakage
Interventions: DEVICE: Transpapillary plastic stent (7-10 Fr)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety, Pharmacokinetics, and Anti-tumor Activity of ABBV-321 in Subjects With Advanced Solid Tumors Associated With Overexpression of the Epidermal Growth Factor Receptor (EGFR)
Status: COMPLETED
Conditions: Advanced Solid Tumors Cancer
Interventions: DRUG: ABBV-321
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Happy Older Latinos Are Active (HOLA) Health Promotion Study in HIV-Infected Latino Men
Status: COMPLETED
Conditions: Human Immunodeficiency Virus|Cardiometabolic Risk
Interventions: BEHAVIORAL: HOLA Component 1|BEHAVIORAL: HOLA Component 2|BEHAVIORAL: HOLA Component 3|BEHAVIORAL: HOLA Component 4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Screening of Cardiac Arrhythmias With Wrist-worn Aino ECG Cardiac Monitor
Status: COMPLETED
Conditions: Arrhythmias, Cardiac|Atrial Fibrillation
Interventions: DEVICE: PulseOn Arrhythmia Monitor device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Trial of FFP+HDMP+Rituximab for Ultra-high Risk Chronic Lymphocytic Leukemia
Status: UNKNOWN
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: FFP+HDMP+Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Low Dose, SubQ Interleukin-2 (IL-2) to Expand Endogenous Regulatory T-Cells in Liver Transplant Recipients
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: BIOLOGICAL: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Plasma, Epithelial Lining, and Alveolar Macrophage Concentrations of Intravenous Carbavance™ (RPX2014/RPX7009) in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: RPX7009 and RPX2014
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT