pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of Ad26.COV2.S and Influenza Vaccines in Healthy Adults
Status: COMPLETED
Conditions: COVID-19 Prevention
Interventions: BIOLOGICAL: Ad26.COV2.S|OTHER: Placebo|BIOLOGICAL: Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of an 8-week Linoleic Acid Intake in Soy Oil on Lp-PLA2 Activity in Healthy Adults
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DIETARY_SUPPLEMENT: Low LA|DIETARY_SUPPLEMENT: High LA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Efficacy and Safety of FRSW107 in Pediatric Patients With Severe Hemophilia A
Status: NOT_YET_RECRUITING
Conditions: Severe Hemophilia A
Interventions: DRUG: FRSW107
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Self-monitoring of Blood Glucose in Patients With Type 2 Diabetes Mellitus Not Using Insulin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Self-monitoring of blood glucose (SMBG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Small Cell Carcinoma of Ovary - Hypercalcemic Type Patient
Status: ACTIVE_NOT_RECRUITING
Conditions: Small Cell Carcinoma, Hypercalcaemic Type|Ovarian Cancer
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preliminary Investigation of β-hydroxybutyrate Supplementation in Colorectal Cancer Prevention
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: R-1,3-Butanediol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Research Study Looking at New Protein-based Tablets in Healthy Men - Oral Formulation II
Status: COMPLETED
Conditions: Healthy Volunteers; High Cholesterol
Interventions: DRUG: NNC0385-0434 G|DRUG: NNC0385-0434 F|DRUG: NNC0385-0434 B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
Status: UNKNOWN
Conditions: Gastro Esophageal Reflux|Barrett Esophagus|Erosive Esophagitis
Interventions: PROCEDURE: Confocal endomicroscopy|DIAGNOSTIC_TEST: Endoscopic biopsies|DIAGNOSTIC_TEST: Mucosal impedance (MI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Test if Fremanezumab is Effective in Preventing Chronic Migraine in Patients 6 to 17 Years of Age
Status: RECRUITING
Conditions: Migraine
Interventions: DRUG: Fremanezumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Mood and Marriage Study (TOMMS)
Status: COMPLETED
Conditions: Major Depressive Disorder|Partner Relational Disorder (V61.10)
Interventions: BEHAVIORAL: Weekly marital therapy|DRUG: As indicated: Sertraline, bupropion, venlafaxine, mirtazepine, nortriptyline, tranylcypromine, lithium augmentation, etc.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Pharmacodynamics of Subcutaneous vs Intravenous Furosemide in Healthy Volunteers
Status: COMPLETED
Conditions: Heart Failure|Fluid Overload
Interventions: DRUG: SCP-111|DRUG: Furosemide USP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peptide-specific Vaccination in HLA-A*02 Positive Patients With Biochemical Recurrence After Radical Prostatectomy
Status: UNKNOWN
Conditions: Recurrent Prostate Cancer
Interventions: BIOLOGICAL: Peptide vaccine|DRUG: Montanide ISA-51|DRUG: Granulocyte macrophage colony stimulating factor (GM-CSF)|DRUG: Imiquimod|DRUG: mRNA|DRUG: Protamin|PROCEDURE: local hyperthermia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Care Coordination: Hospital to Home for Cognitively Impaired Older Adults and Their Caregivers
Status: COMPLETED
Conditions: Dementia|Dementia, Vascular|Alzheimer Disease|Delirium, Dementia, Amnestic, Cognitive Disorders|Lewy Body Disease|Mild Cognitive Impairment
Interventions: BEHAVIORAL: Augmented Standard Care (ASC)|BEHAVIORAL: Resource Nurse Care (RNC)|BEHAVIORAL: Advanced Practice Nurse Care (APNC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Autologous Stem Cell Rescue for Primary Amyloidosis
Status: COMPLETED
Conditions: Amyloidosis|Blood and Marrow Transplant (BMT)
Interventions: PROCEDURE: high dose chemo then auto hematopoietic cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Presenting Summary Information From Cochrane Systematic Reviews: Protocol for Research of Infographics Presentation vs. Plain Language Summary
Status: COMPLETED
Conditions: Health Knowledge, Attitudes, Practice
Interventions: OTHER: Infographics|OTHER: PLS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of GS-4571 in Healthy Participants, Nondiabetic Obese Participants, and Nonobese Participants With Type 2 Diabetes Mellitus (T2DM)
Status: NOT_YET_RECRUITING
Conditions: Weight Management
Interventions: DRUG: GS-4571|DRUG: Placebo|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Intravenous Amino Acid Infusion to Prevent Contrast Dye Mediated Renal Damage
Status: WITHDRAWN
Conditions: Contrast Nephropathy|Renal Failure
Interventions: DRUG: Amino Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Investigation of Plaque Instability Using Bevacizumab-800CW and MSOT
Status: UNKNOWN
Conditions: Atherosclerosis|Carotid Stenosis|Fluorescence
Interventions: DEVICE: MultiSpectral Optoacoustic Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study to Evaluate the Efficacy and Safety of AD-224
Status: RECRUITING
Conditions: Hypertension,Essential
Interventions: DRUG: AD-224A|DRUG: AD-224B|DRUG: AD-224C|DRUG: Placebo of AD-224A|DRUG: Placebo of AD-224B|DRUG: Placebo of AD-224C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ZeroTolerance Mucositis: Managing Oral and Alimentary Mucositis With High Potency Sucralfate - ProThelial
Status: UNKNOWN
Conditions: Oral Mucositis|Nausea|Vomiting|Diarrhea
Interventions: DEVICE: ProThelial
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PRESERVE-Zenith® Branch Endovascular Graft-Iliac Bifurcation Clinical Study
Status: COMPLETED
Conditions: Aortoiliac Aneurysms|Iliac Aneurysms
Interventions: DEVICE: Zenith® Branch Endovascular Graft-Iliac Bifurcation,|DEVICE: Atrium iCAST™|DEVICE: Zenith® Flex AAA Endovascular Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magseed and Magtrace Localization for Breast Cancer
Status: COMPLETED
Conditions: Breast Carcinoma|Breast Carcinoma Metastatic in Lymph Node
Interventions: PROCEDURE: Magseed|PROCEDURE: Magtrace|PROCEDURE: Axillary lymph node metastasis - needle biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Continuous Monitoring on the General Ward
Status: COMPLETED
Conditions: Carcinoma, Pancreatic Ductal|Colorectal Neoplasms|Arthritis|Hypertension|Sepsis
Interventions: DEVICE: HealthPatch|DEVICE: ViSi Mobile
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prebiotics and Probiotics During Definitive Treatment With Chemotherapy-radiotherapy SCC of the Anal Canal (BISQUIT)
Status: RECRUITING
Conditions: Anal Cancer Squamous Cell
Interventions: DIETARY_SUPPLEMENT: prebiotics in combination with probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enzastaurin and Temozolomide in Treating Patients With Primary Gliomas
Status: UNKNOWN
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: enzastaurin hydrochloride|DRUG: temozolomide|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 6 vs 12 Sessions in Low Intensity Extracorporeal Shock Wave Treatment (LI-ESWT) for Erectile Dysfunction (ED)
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DEVICE: Dornier Aries- ED device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Chinese Traditional Medicine "Smart Soup" in Cognition and Behavior Regulation in Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer Disease|Mild Cognitive Impairment
Interventions: DRUG: smart soup|DRUG: Donepezil|DRUG: Memantine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Balanced Anesthesia Regimen on Intraoperative Trans-cranial Motor Evoked Potential During Spine Surgeries:
Status: COMPLETED
Conditions: Motor Evoked Potential
Interventions: DRUG: Propofol Abbott|DRUG: Sevoflurane Inhalation Solution|DIAGNOSTIC_TEST: transcranial motor evoked potential(Tcm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of LOU064 in Inadequately Controlled Asthma Patients
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: LOU064 100 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Ulcerative Colitis (UC)
Status: RECRUITING
Conditions: Colitis, Ulcerative
Interventions: DRUG: Vedolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ActiPatch Therapy for Back Pain
Status: UNKNOWN
Conditions: Back Ache
Interventions: DEVICE: ActiPatch (active)|DEVICE: ActiPatch (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reliability of Simple Sonographic Findings Acquired With Hand-held Apparatuses to Inform Obstetric Diagnosis
Status: COMPLETED
Conditions: Obstetric Complication|Vaginal Bleeding|Eclampsia Preeclampsia|Obstructed Labor|Antepartum Hemorrhage
Interventions: DIAGNOSTIC_TEST: point of care ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pimecrolimus Cream 1% in Patients (18 Years of Age and Over) With Mild to Moderate Chronic Hand Dermatitis
Status: COMPLETED
Conditions: Chronic Hand Dermatitis
Interventions: DRUG: Pimecrolimus Cream 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Coformulated Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib (E7080/MK-7902) in Advanced Hepatocellular Carcinoma (MK-1308A-004)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Hepatocellular Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab/Quavonlimab|DRUG: Lenvatinib|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing French Ambulatory and MISGAV-LADACH C-Section Techniques
Status: COMPLETED
Conditions: Cesarean Section
Interventions: PROCEDURE: FAUCS|PROCEDURE: MLC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Clinical Trial Comparing the Efficacy of Darunavir/Ritonavir Monotherapy Versus a Triple Combination Therapy Containing Darunavir/Ritonavir and 2 Nucleoside/Nucleotide Reverse Transcriptase Inhibitors in Patients With Undetectable Plasma HIV-1 RNA on Current Treatment
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV) Infections|Acquired Immunodeficiency Syndrome (AIDS) Virus
Interventions: DRUG: Darunavir|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Epidural Steroid Injections on Glycemic Control in Diabetic Patients According to the Doses of Steroids
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: epidural steroid injection with Triamcinolone 40mg|OTHER: Selective transforaminal epidural block with triamcinolone 20 mg|OTHER: caudal epidural steroid injection with Triamcinolone 20mg|OTHER: Selective transforaminal epidural block with triamcinolone 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Comparison of rTMS and H Coil in Neuropathic Pain
Status: COMPLETED
Conditions: Central Pain Syndrome
Interventions: DEVICE: rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Desflurane Versus Isoflurane for Speeding Postanesthetic Recovery and Hospital Discharge
Status: NOT_YET_RECRUITING
Conditions: Surgery
Interventions: DRUG: Desflurane|DRUG: Isoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Utilization of Motor Imagery Training for Improvement of Balance of Ataxic Children After Medulloblastoma Resection
Status: COMPLETED
Conditions: Cerebellar Ataxia
Interventions: OTHER: motor imaginary training|OTHER: physical therapy training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Implementation of an Efficacious Intervention for High Risk Women in Mexico
Status: COMPLETED
Conditions: HIV|Syphilis|Gonorrhea|Chlamydia
Interventions: BEHAVIORAL: Mujer Segura|BEHAVIORAL: CENSIDA counseling program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Cogmed Working Memory Training for Adult Hearing Aid Users
Status: COMPLETED
Conditions: Hearing Loss
Interventions: BEHAVIORAL: Cogmed RM - Online adaptive working memory training|BEHAVIORAL: Cogmed RM - Online non-adaptive (placebo) working memory training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Treating Tricuspid Regurgitation With K-ClipTM Transcatheter Annuloplasty System
Status: RECRUITING
Conditions: Tricuspid Regurgitation
Interventions: DEVICE: Transcatheter Annuloplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Database Survey of Comparison The Risk of Haemorrhage Between Vortioxetine Tablet Treatment and Selective Serotonin Reuptake Inhibitor (SSRI) Treatment in Participants With Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Vortioxetine Tablet|DRUG: SSRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Effect of Ibrutinib on the Pharmacokinetics of Oral Contraceptives, CYP2B6, and CYP3A4 Substrates in Female Participants With B Cell Malignancy
Status: COMPLETED
Conditions: Leukemia, Lymphocytic, Chronic, B-Cell
Interventions: DRUG: Ibrutinib|DRUG: OC: Ethinylestradiol (EE) 30 mcg and Levonorgestrel (LN) 150 mcg|DRUG: Bupropion|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Expanded Access for the Prevention of Acute Attacks of 1) Hereditary Angioedema (HAE) in Children and 2) Non-histaminergic Angioedema With Normal C1-Inhibitor (C1-INH) in Teenagers and Adults
Status: NO_LONGER_AVAILABLE
Conditions: Hereditary Angioedema (HAE)|Angioedema
Interventions: DRUG: Lanadelumab 150 mg|DRUG: Lanadelumab 300 mg
Study Type: EXPANDED_ACCESS
Clinical trial: Bladder Washing Cytology for Detection of Urothelial Carcinoma Using Catheter or Flexible Cystoscope: Which is Better?
Status: RECRUITING
Conditions: Bladder Cancer
Interventions: DEVICE: Flexible cystoscopy|DEVICE: Urinary catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Chemoradiotherapy Following Immunotherapy Plus Chemotherapy for Locally-advanced Esophageal Squamous Cell Cancer (RICE)
Status: NOT_YET_RECRUITING
Conditions: Esophageal Squamous Cell Carcinomas|Concurrent Chemoradiotherapy|Immunotherapy|Chemotherapy
Interventions: DRUG: chemotherapy combined with PD-1 inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Activity of Intravenous MLDL1278A in Patients on Standard-of-Care Therapy for Stable Atherosclerotic Cardiovascular Disease (GLACIER)
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DRUG: MLDL1278A|DRUG: MLDL1278A|DRUG: placebo|DRUG: statin, stable dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Effectiveness of Mainstream Management Tools to Increase Organizational Commitment and Job Satisfaction and Decrease Turnover Among Peer Providers
Status: ACTIVE_NOT_RECRUITING
Conditions: Mental Health|Work Related Stress
Interventions: BEHAVIORAL: Coaching and Advancement for Peer Providers (CAPP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multisystem Shortness of Breath Evaluation Study
Status: UNKNOWN
Conditions: Dyspnea
Interventions: DIAGNOSTIC_TEST: Pulmonary function studies|DIAGNOSTIC_TEST: Echocardiogram|DIAGNOSTIC_TEST: Electrocardiogram|DIAGNOSTIC_TEST: Chest radiography|DIAGNOSTIC_TEST: Blood test|BEHAVIORAL: Quality of life questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exercise: Addressing Stress in Relapse Prevention for Substance Use Disorders
Status: COMPLETED
Conditions: Substance Use Disorders
Interventions: BEHAVIORAL: Motivational enhancement therapy (MET)|BEHAVIORAL: Contingency management|BEHAVIORAL: Standard Aftercare Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy of the Treatment of Iatrogenic Subcutaneous Abdominal Wounds (ISAW) After Surgery by Application of Negative Pressure Wound Therapy (NPWT) in Comparison to Standard Conventional Wound Therapy (SCWT) of the Clinical Routine
Status: TERMINATED
Conditions: Postoperative Abdominal Wounds|Wound-healing Impairments
Interventions: DEVICE: Negative Pressure Wound Therapy|OTHER: Standard Wound Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PBI-0451 (Pomotrelvir) Phase 2 Study in Nonhospitalized Symptomatic Adults With COVID-19
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: DRUG: PBI-0451 (Pomotrelvir)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: In-Person vs e-Health Mindfulness-Based Intervention for Adolescents With Chronic Illness
Status: COMPLETED
Conditions: Chronic Illness|Mental Health Impairment
Interventions: BEHAVIORAL: MARS-A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Minocycline Treatment in Retinitis Pigmentosa
Status: COMPLETED
Conditions: Retinitis Pigmentosa|Inherited Retinal Dystrophy|Retina Disorder
Interventions: DRUG: Minocycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sirius in Gynaecological Laparoscopic Surgery
Status: RECRUITING
Conditions: Ovarian Cancer|Cervical Cancer|Gynecologic Cancer
Interventions: DEVICE: Gynaecological laparoscopic surgery (Sirius System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Cervical Cancer|Head and Neck Squamous Cell Carcinoma
Interventions: BIOLOGICAL: Volrustomig
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest Balance Auto-immune Population in Patients With Focal Epilepsy of Unknown Cause, Not Structural, Not Genetics, Newly Diagnosed
Status: UNKNOWN
Conditions: Epilepsy
Interventions: BIOLOGICAL: Focal epilepsy of unknown cause
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: D-cycloserine Augmented CBT for Panic Disorder
Status: TERMINATED
Conditions: Panic Disorder
Interventions: DRUG: d-cycloserine|DRUG: placebo|BEHAVIORAL: cognitive-behaviour therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hypophosphatemia With Ferric Carboxymaltose Vs. Iron Dextran in Iron Deficiency Secondary to Heavy Uterine Bleeding
Status: COMPLETED
Conditions: Iron Deficiency Anemia
Interventions: DRUG: Ferric Carboxymaltose (FCM)|DRUG: Iron Dextran Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Night Respite for Postpartum Mothers With SUD
Status: RECRUITING
Conditions: Opioid Use Disorder|Maternal Drugs Affecting Fetus|Postpartum Mood Disturbance|Sleep Disorder|Neonatal Opioid Withdrawal
Interventions: BEHAVIORAL: Night Respite Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LY231514 Plus Gemcitabine in Treating Women With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: pemetrexed disodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gain and Loss Framed Text Messaging to Reduce Drinking Among Older Adults
Status: RECRUITING
Conditions: Alcohol Consumption
Interventions: BEHAVIORAL: Brief Normative Feedback|BEHAVIORAL: Loss-framed Text-messaging|BEHAVIORAL: Gain-framed Text-messaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Conventional Photodynamic Therapy vs. Painless Photodynamic Therapy for Moderate or Severe Acne
Status: UNKNOWN
Conditions: Acne
Interventions: PROCEDURE: Aminolevulinic acid photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Acceptability, Skin Barrier Restoration and Balance of Atopic Skin Using Moisturizer
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: OTHER: Moisturizer containing saccharide isomerate and niacinamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial to Evaluate the Efficacy and Safety of TQB2102 for Injection Versus Investigator-Selected Chemotherapy in HER2 Low-Expressing Recurrent/Metastatic Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: TQB2102 for Injection|DRUG: Chemotherapy drug (Capecitabine/Paclitaxel/Albumin Paclitaxel)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Citalopram for Agitation in Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease|Agitation
Interventions: DRUG: citalopram|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physiotherapy After Anterior Cervical Spine Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Disc Disease|Radiculopathy, Cervical
Interventions: OTHER: Prescribed Physical Activity|OTHER: Exercises with Internet support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Assessing the Effect of Nabilone on Pain and Quality of Life in Patients With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: Nabilone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety, Efficacy and Pharmacokinetic Study of BTCT4465A (Mosunetuzumab) as a Single Agent and Combined With Atezolizumab in Non-Hodgkin's Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphocytic Leukemia, Chronic|Lymphoma, Non Hodgkin
Interventions: DRUG: BTCT4465A (Mosunetuzumab) IV|DRUG: Atezolizumab|DRUG: BTCT4465A (Mosunetuzumab) SC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventive Versus Curative Treatment of Fluid Overload
Status: RECRUITING
Conditions: Respiratory Insufficiency
Interventions: OTHER: Preventive initiation of fluid removal|OTHER: Curative initiation of fluid removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: BONAMI (BOne Marrow in Acute Myocardial Infarction)
Status: COMPLETED
Conditions: Acute and Severe Myocardial Infarction
Interventions: PROCEDURE: Intracoronary injection of autologous bone marrow mononuclear cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incidence of Pulmonary Embolism During Temporary Pacing Via Femoral Versus Subclavian Vein
Status: UNKNOWN
Conditions: Pulmonary Embolism
Interventions: PROCEDURE: temporary pacing femoral vein|PROCEDURE: temporary pacing subclavian vein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In-depth Characterization of Atriogenic Secondary Tricuspid Regurgitation Due to Atrial Fibrillation
Status: RECRUITING
Conditions: Heart Valve Incompetence|Atrial Fibrillation, Persistent
Interventions: DIAGNOSTIC_TEST: Echocardiography|COMBINATION_PRODUCT: Proteomic analyses
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Between Digital 3D Printed Transfer Tray Versus Thermoformed Transfer Tray for Indirect Bonding
Status: UNKNOWN
Conditions: Orthodontic Indirect Bonding
Interventions: PROCEDURE: Digital indirect bonding|PROCEDURE: Conventional indirect bonding|PROCEDURE: Intraoral scanning|PROCEDURE: Superimposition and evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Telehealth and Onsite Maintenance Exercise in Chronic Lung Disease
Status: RECRUITING
Conditions: Copd|COPD Exacerbation|COPD Bronchitis|Emphysema or COPD|Chronic Lung Disease|Pulmonary Fibrosis|Interstitial Lung Disease|Bronchiectasis|Chronic Asthma|Chronic Asthmatic Bronchitis
Interventions: COMBINATION_PRODUCT: Onsite Maintenance Exercise Training|COMBINATION_PRODUCT: Telehealth Maintenance Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis Patients
Status: RECRUITING
Conditions: Thyroid; Functional Disturbance|Hypothyroidism|Hemodialysis
Interventions: DRUG: Levothyroxine Sodium|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aliskiren's Effect on Arterial Stiffness and Platelet Function in Patients With Diabetes Mellitus (DM)
Status: UNKNOWN
Conditions: Diabetes Mellitus|Atherosclerosis
Interventions: DRUG: aliskiren|DRUG: losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Biportal Endoscopy Spine Surgery (BESS )Versus Unilateral Laminotomy Bilateral Decompression (ULBD ): RCT, Non-inferiority Trial
Status: COMPLETED
Conditions: Degenerative Lumbar Spinal Stenosis
Interventions: PROCEDURE: BESS|PROCEDURE: ULBD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Atezolizumab Compared With Chemotherapy in Participants With Locally Advanced or Metastatic Urothelial Bladder Cancer [IMvigor211]
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: Atezolizumab (MPDL3280A) [TECENTRIQ], an engineered anti-PDL1 antibody|DRUG: Docetaxel|DRUG: Paclitaxel|DRUG: Vinflunine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Preliminary Efficacy of 177Lu-OPS201 in NETs
Status: TERMINATED
Conditions: Neuroendocrine Tumors
Interventions: DRUG: Satoreotide tetraxetan|OTHER: Amino acid solution|OTHER: Antiemetic
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Laser Therapy, Continuous and Pulsed Light, for Major Depressive Disorder (ELATED-3)
Status: COMPLETED
Conditions: Depression|Major Depressive Disorder
Interventions: DEVICE: Transcranial Light Therapy|DEVICE: Sham Transcranial Light Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Wavefront Analyzes and Visual Performance of Three Multifocal Intra-ocular Lenses
Status: COMPLETED
Conditions: Cataract|Astigmatism
Interventions: DEVICE: Tecnis implant|DEVICE: ReSTOR implant|DEVICE: ReZoom implant
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess How Much Drug Reaches the Blood When Given From Symbicort pMDI With Spacer Compared to That of Symbicort pMDI Without Spacer in Healthy Volunteers
Status: COMPLETED
Conditions: Study is Being Conducted in Healthy Volunteers
Interventions: DRUG: Symbicort pMDI with spacer device|DRUG: Symbicort pMDI without spacer device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vahelva Respimat Regulatory Post-marketing Surveillance in Korean Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Vahelva® Respimat® (Tiotropium + Olodaterol fixed dose combination)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study in Healthy Subjects to Assess the Safety, Tolerability, PK and PD of HTL0030310
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HTL0030310|DRUG: Pasireotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gene Therapy and Radioactive Iodine in Treating Patients With Locally Recurrent Prostate Cancer That Did Not Respond to External-Beam Radiation Therapy
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: Ad5-CMV-NIS|DRUG: liothyronine sodium|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: laboratory biomarker analysis|RADIATION: iodine I 131
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Patients With Major Depressive Disorder With MK0869 (0869-062)(COMPLETED)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: aprepitant|DRUG: Comparator: paroxetine HCL|DRUG: Comparator: Placebo (Unspecified)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Two Dose Levels of Didanosine Used in Combination With Stavudine in HIV-Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Stavudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Postop Hypospadias Pain
Status: UNKNOWN
Conditions: Hypospadias
Interventions: DRUG: Acetaminophen, Ibuprofen|DRUG: Acetaminophen, Ibuprofen, Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Comparison of Robotic and Endoscopic SMG Resection Via Retroauricular Approach
Status: WITHDRAWN
Conditions: SMG Resection in Comparison to Endoscopic SMG Resection
Interventions: DEVICE: Robotic SMG resection|DEVICE: Endoscopic SMG resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nepal Undifferentiated Febrile Illness Trial
Status: COMPLETED
Conditions: Undifferentiated Febrile Illness
Interventions: DRUG: Azithromycin|DRUG: Co-trimoxazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Preoperative Ketamine on the Emergence Characteristics in Children Undergoing Entropion Surgery
Status: COMPLETED
Conditions: Entropion
Interventions: DRUG: Sevoflurane|DRUG: Desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Real World Evidence Study on Metastatic Prostate Cancer in the Pirkanmaa Hospital District in Finland
Status: COMPLETED
Conditions: Metastatic Castration Sensitive Prostate Cancer (mCSPC)|Metastatic Castration Resistant Prostate Cancer (mCRPC)
Interventions: DRUG: abiraterone|DRUG: enzalutamide|DRUG: docetaxel|DRUG: apalutamide|DRUG: cabazitaxel|DRUG: Radium-223|DRUG: Lutetium-177|DRUG: degarelix|DRUG: goserelin|DRUG: leuprorelin|DRUG: triptorelin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Galeazzi Spine Surgery RegistryGaleazzi Spine Registry: Prospective Study for Clinical Monitoring
Status: RECRUITING
Conditions: Patients Undergoing Spine Surgery|Scoliosis|Disc Disease|Disc Injury|Myelopathy|Spinal Stenosis|SPINAL Fracture|Spinal Fusion
Interventions: OTHER: Spine Surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Single Dose Oral Cholera Vaccine Study in Dhaka, Bangladesh
Status: COMPLETED
Conditions: Cholera
Interventions: BIOLOGICAL: Shanchol|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase Ib/II Trial of Belotecan and Ifosfamide in Patients With Extensive Disease of Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Belotecan and Ifosfamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy and Safety of Benralizumab in Reducing Oral Corticosteroid Use in Adult Patients With Severe Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: Benralizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Adalimumab in Treatment of Hidradenitis Suppurativa
Status: COMPLETED
Conditions: Hidradenitis Suppurativa (HS)
Interventions: BIOLOGICAL: adalimumab|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Follow-up Comparison of Active Versus Passive Manual Therapy in Patients With Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain|Manual Therapy|Education
Interventions: OTHER: Manual Therapy with Traditional Biomechanical Explanation|OTHER: Manual Therapy with Neuroplastiicity Explanation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Corneal Endothelial Changes Following Pediatric Cataract Surgery With IOL Implantation
Status: COMPLETED
Conditions: Congenital Cataract Surgery|IOL Implantation|Change in Corneal Endothelial Cell Morphology
Interventions: PROCEDURE: Congenital Cataract Surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Validation of a Hybrid BCI-controlled FES for Upper Limb Rehabilitation After Stroke
Status: RECRUITING
Conditions: Stroke Sequelae|Motor Disorders
Interventions: DEVICE: RECOM - hBCI training|OTHER: CTRL - upper limb training with FES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Helmet CPAP Versus HFNC in COVID-19
Status: TERMINATED
Conditions: COVID|Acute Hypoxemic Respiratory Failure
Interventions: DEVICE: Helmet CPAP|DEVICE: HFNC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Robot Walking Rehabilitation in Parkinson's Disease
Status: COMPLETED
Conditions: Idiopathic Parkinson's Disease|Progressive Supranuclear Palsy
Interventions: DEVICE: Robot-Assisted Gait Training (RAGT)|PROCEDURE: Treadmill Gait Training (TT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Preventing Aggression In Veterans With Dementia (PAVED) - Telephone Sub-Study With Rural Veterans
Status: UNKNOWN
Conditions: Dementia|Pain
Interventions: BEHAVIORAL: Preventing Aggression in Veterans with Dementia (PAVeD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nanobody-based Biepitope CAR-T Cells Targeting BCMA in the Treatment of R/RMM
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Nanobody-based biepitope BCMA-targeting CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Fustra-Exercise Program in Neck and Low Back Pain
Status: COMPLETED
Conditions: Neck Pain|Low Back Pain, Recurrent
Interventions: BEHAVIORAL: Neuromuscular exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of IW-3300 for the Treatment of Bladder Pain in Subjects With Interstitial Cystitis/Bladder Pain Syndrome
Status: RECRUITING
Conditions: Interstitial Cystitis|Bladder Pain Syndrome
Interventions: DRUG: IW-3300 rectal foam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Target Volume Based on Disease Extension Risk Atlas and Computer-aided Delineation in Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Neoplasms
Interventions: RADIATION: IMRT using individualized CTV|RADIATION: IMRT using traditional CTV|DRUG: Gemcitabine and cisplatin (induction chemotherapy)|DRUG: Docetaxel and cisplatin (induction chemotherapy)|DRUG: Cisplatin 100mg/m² concurrent chemotherapy|DRUG: Cisplatin 80mg/m² concurrent chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Outcome of Injured Cervical Spinal Cord With Uncontrolled Swelling Under Duraplasty
Status: NOT_YET_RECRUITING
Conditions: Spine Injury|Cord Injury, Spinal|Cord Infarction Spinal|Incomplete Spinal Cord Injury|Complete Spinal Cord Injury
Interventions: PROCEDURE: Duroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-Site Randomized Clinical Study of Tinnitus Treatment Methods
Status: COMPLETED
Conditions: Tinnitus
Interventions: PROCEDURE: Tinnitus Masking|PROCEDURE: Tinnitus Retraining Therapy (TRT)|PROCEDURE: Tinnitus Education (TED)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antireflux Efficacy of Hiatal Hernia Repairs in Sleeve Gastrectomy Patients
Status: TERMINATED
Conditions: Gastroesophageal Reflux
Interventions: PROCEDURE: Sleeve gastrectomy|PROCEDURE: Hiatal Hernia repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of N-acetylcystein in Myocardial Infarction
Status: UNKNOWN
Conditions: Acute Myocardial Infarction
Interventions: DRUG: N-acetylcystein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Bonviva (Ibandronate) Once Monthly in Post-Menopausal Women With Osteopenia.
Status: COMPLETED
Conditions: Post-Menopausal Osteopenia
Interventions: DRUG: ibandronate [Bonviva/Boniva]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Electronic Informed Consent Information (EICI) on Residual Newborn Specimen Research
Status: COMPLETED
Conditions: Neonatal Screening
Interventions: BEHAVIORAL: EICI Movie|BEHAVIORAL: EICI App|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparing Continuation or De-escalation of Bone Modifying Agents (BMA) in Patients Treated for Over 2 Years for Bone Metastases From Either Breast or Castration-resistant Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Castration-resistant Prostate Cancer
Interventions: DRUG: Bone modifying agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Escalating Doses of BPN-14967 in Healthy Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: BPN-14967|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Depletive Lumbar Puncture on Lower Urinary Tract Dysfunction in iNPH
Status: UNKNOWN
Conditions: Normal Pressure Hydrocephalus
Interventions: DIAGNOSTIC_TEST: Urinary symptoms profile questionnaire|DIAGNOSTIC_TEST: Micturition calendar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC