pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Prevention of Fascial Dehiscence With Prophylactic Onlay Mesh in Emergency Laparotomies
Status: COMPLETED
Conditions: Surgical Wound Dehiscence
Interventions: DEVICE: prophylactic polypropilene mesh|PROCEDURE: Midline Fascial Closure|DEVICE: vacuum drainage system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Cannabinoid Tablets for the Treatment of Pain From Osteoarthritis of the Knee
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DRUG: CBD/CBN|DRUG: CBD/THC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Trilaciclib Combined With mFOLFIRINOX in the Treatment of Patients With Advanced Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Trilaciclib+mFOLFIRINOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Therapies in Japanese Participants With Advanced Cancer
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DRUG: Abemaciclib|DRUG: Abiraterone Acetate|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lipitor Trial To Study The Effect Of Torcetrpib/Atorvastatin To Atorvastatin Alone.
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DRUG: torcetrapib/atorvastatin|DRUG: atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Communicating With Patients on Cancer Resistance to Treatment: the Development of a Communication Tool. (HECTOR)
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Uveal Melanoma|Triple Negative Breast Cancer|Luminal B Breast Cancer|Pediatric Cancer
Interventions: BEHAVIORAL: Questionnaires|BEHAVIORAL: Semi-structured individual interviews|OTHER: Focus Group|OTHER: DELPHI Consensus Method
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Vaccine Therapy in Treating Patients With HER2/Neu Positive or Negative Stage IV Breast Cancer or Other HER2/Neu Positive Cancers
Status: TERMINATED
Conditions: Breast Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: allogeneic GM-CSF-secreting breast cancer vaccine|BIOLOGICAL: recombinant interferon alfa|DRUG: cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of a Silica Microparticle Taggant System to Measure ART Adherence
Status: NOT_YET_RECRUITING
Conditions: Hiv|Medication Adherence|Compliance, Medication
Interventions: DEVICE: TruTag System|DRUG: Biktarvy Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Prospective, Single Blinded Study for Predicting Colon Polyp Histology With Narrow Band Imaging
Status: UNKNOWN
Conditions: Colonoscopy|Adenomatous Polyp|Neoplastic
Interventions: OTHER: Narrow Band Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Mindfulness Meditation Versus Physical Exercise: Comparing Effects on Stress and Immunocompetence
Status: COMPLETED
Conditions: Stress|Health Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: Mindfulness meditation|BEHAVIORAL: Physical exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bladder PREserVation by RadioTherapy and Immunotherapy in BCG Unresponsive Non-muscle Invasive Bladder Cancer
Status: UNKNOWN
Conditions: Non-muscle-invasive Bladder Cancer
Interventions: DRUG: Avelumab|DEVICE: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Mesenchymal Stem Cells to Fill Bone Void Defects in Patients With Benign Bone Lesions
Status: WITHDRAWN
Conditions: Bone Neoplasms
Interventions: BIOLOGICAL: Trinity multipotent stem cells|BIOLOGICAL: Demineralized bone matrix(DBM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Human Rabies Immunoglobulin (HRIG)- Dosage Determination and Interference With the Active Immune Response
Status: COMPLETED
Conditions: Rabies
Interventions: BIOLOGICAL: Human Rabies Immune Globulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Relief in Premature Newborns Through Maternal Intervention During Venipuncture
Status: RECRUITING
Conditions: Premature Newborns
Interventions: OTHER: Analgesic strategies during the S visit:|OTHER: Analgesic strategies at visit M
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Music Therapy as an Adjunct in CIED Lead Extraction Procedures
Status: COMPLETED
Conditions: C.Surgical Procedure|Stress|Pain, Procedural|Anxiety
Interventions: BEHAVIORAL: Facilitated Music Listening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Client-Centered Breastfeeding Support: Effects on Primipara Mothers in a Randomized Trial Breastfeeding Self-Efficacy, Attitudes, and Problems in Primiparous Mothers: A Randomized Controlled Trial
Status: RECRUITING
Conditions: Breastfeeding Self-Efficacy Attitude to Health Postpartum Period Primiparity
Interventions: BEHAVIORAL: IMCHB-Based Breastfeeding Support Program|BEHAVIORAL: Standard Breastfeeding Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)
Status: RECRUITING
Conditions: H3 K27M|Glioma
Interventions: DRUG: Dordaviprone (ONC201)|DRUG: Dordaviprone (ONC201) + Placebo|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Safety, Tolerability, and Pharmacokinetics of UCB0599 in Healthy Study Participants and Patients With Parkinson's Disease (PD)
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: UCB0599|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Abiraterone and Prednisone or Darolutamide for the Treatment of Advanced Prostate Cancer
Status: RECRUITING
Conditions: Advanced Prostate Adenocarcinoma|Stage III Prostate Cancer AJCC v8|Stage IV Prostate Cancer AJCC v8
Interventions: DRUG: Abiraterone|PROCEDURE: Biospecimen Collection|DRUG: Darolutamide|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: tACS for Sensory Motor Recovery After Stroke
Status: NOT_YET_RECRUITING
Conditions: Motor Recovery
Interventions: DEVICE: tACS Sham|DEVICE: tACS 10Hz|DEVICE: tACS 20Hz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: TARGTEPO Treatment for Anemia in End Stage Renal Disease (ESRD) Patients Undergoing Peritoneal Dialysis (PD)
Status: TERMINATED
Conditions: Anemia of End Stage Renal Disease
Interventions: BIOLOGICAL: MDGN201 TARGTEPO
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Buck Institute Ketone Ester RCT
Status: COMPLETED
Conditions: Tolerance|Safety Issues|Aging
Interventions: OTHER: Ketone ester|OTHER: Non-ketone placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Vestibular Rehabilitation for Unsteadiness After Intratympanic Gentamicin in Patients With Meniere's Disease
Status: NOT_YET_RECRUITING
Conditions: Vestibular Disorder
Interventions: DRUG: Usual care|OTHER: Health Education|BEHAVIORAL: vestibular rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective SPINE Registry
Status: RECRUITING
Conditions: Sacroiliac; Fusion|Sacroiliac|Joint Diseases|Musculoskeletal Diseases|Spinal Disease|Spinal Stenosis|Spinal Instability|Fusion of Joint|Fusion of Spine|Spinal Fusion|Spine
Interventions: DEVICE: RTI Spine products
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intravenous Terbutaline to Facilitate Labor Epidural Catheter Placement
Status: UNKNOWN
Conditions: Labor Pain
Interventions: DRUG: Terbutaline|DRUG: Fentanyl|DRUG: 0.9% NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Calcipotriene/Betamethasone Gel/Ointment in Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Calcipotriene/betamethasone gel and ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Three Weight-adjusted Vasopressors for Elective Cesarean Delivery
Status: COMPLETED
Conditions: Cesarean Section Complications
Interventions: DRUG: metaraminol|DRUG: Phenylephrine|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Interleukin-2 Following Bone Marrow Transplantation in Treating Patients With Hematologic Cancer
Status: COMPLETED
Conditions: Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Clinical Study, Multicenter, Randomized With 2 Arms of Pantoprazole + Domperidone and Pantoprazole Isolated at the Gastroesophageal Reflux Disease
Status: WITHDRAWN
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: Pantoprazole + Domperidone|DRUG: Pantozol®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Surgery Plus Reduced Target Chemoradiotherapy vs Surgery Plus Reduced Dose Chemoradiotherapy for Newly Diagnosed Operable Nasopharyngeal Carcinoma.
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: RADIATION: Surgery combined with Target-reduction intensity-modulated radiotherapy|RADIATION: Surgery combined with Dose-reduction intensity-modulated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of Low Level Laser Light Therapy for Autistic Disorder
Status: COMPLETED
Conditions: Autistic Disorder
Interventions: DEVICE: Erchonia HLS Laser|DEVICE: Placebo Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adapted Fluence Settings for Corneal Collagen Cross-linking in Mild to Moderate Progressive Keratoconus
Status: UNKNOWN
Conditions: Keratoconus
Interventions: RADIATION: adjusted corneal collagen cross-linking|RADIATION: accelerated corneal collagen cross-linking|DRUG: riboflavin 0.1% combined with dextran 20 %|PROCEDURE: epithelial debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of CGA on QoL in Older Patients With Cancer Receiving Systemic Therapy
Status: COMPLETED
Conditions: Geriatrics|Comprehensive Geriatric Assessment
Interventions: BEHAVIORAL: CGA coordination by geriatric team including intensive patient coaching and follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Virtual Reality Use on Disaster Literacy, Disaster Readiness and Disaster Resilience
Status: NOT_YET_RECRUITING
Conditions: Public Health Nursing
Interventions: OTHER: Educaiton group|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study in Healthy Men to Test Whether Zongertinib Influences the Amount of 4 Other Medicines (Dabigatran, Rosuvastatin, Metformin, and Furosemide) in the Blood
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: Zongertinib|DRUG: Dabigatran-etexilate|DRUG: Rosuvastatin|DRUG: Metformin hydrochloride|DRUG: Furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pain Control in Different Bupivacaine Dose in Periarticular Injection in Bilateral Total Knee Arthroplasty
Status: COMPLETED
Conditions: Bilateral Total Knee Arthroplasty
Interventions: PROCEDURE: bupivacaine 200 mg|DRUG: bupivacaine 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Once-Daily Investigational Nasal Spray In Adults And Adolescents With Seasonal Allergic Rhinitis (SAR)
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal
Interventions: DRUG: GW685698X Aqueous Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Weight Bearing Exercises With and Without Jaffrey's Core Stability Exercise Training in Children With Down Syndrome.
Status: NOT_YET_RECRUITING
Conditions: Down Syndrome
Interventions: OTHER: Weight bearing exercises|OTHER: Jaffrey's core stability exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Capsaicin 179 mg Patch Versus Oral Duloxetine in Patients With Chemotherapy-induced Peripheral Neuropathy
Status: RECRUITING
Conditions: Chemotherapy-induced Peripheral Neuropathy
Interventions: DRUG: Capsaicin|DRUG: Duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Oxytocin on Affective Touch
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: intranasal oxytocin|DRUG: intranasal placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study in Healthy Subjects to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-06687234
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: PF-06687234|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Assess Full-fat or Low-fat Dairy Foods on Insulin Sensitivity, RBC FA's and Other Markers of Metabolic Health
Status: ENROLLING_BY_INVITATION
Conditions: Overweight and Obesity|Elevated Triglycerides
Interventions: OTHER: Full-fat fermented dairy|OTHER: Low-fat fermented dairy|OTHER: Non-dairy, non-fermented foods
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase I/II, Multi-Center, Open-Label, Dose-Escalation, Safety and Efficacy Study of PHY906 Plus Capecitabine in Patients With Advanced Pancreatic Carcinoma
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Capecitabine|DRUG: PHY906
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Emollient on Xerosis in Children With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: V0034CR01B|DRUG: Vehicle cream|DRUG: desonide 0.1% cream|OTHER: Foaming gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Small Doses Muscle Relaxant in General Anesthesia
Status: RECRUITING
Conditions: Muscle Relaxant
Interventions: DRUG: Atracurium Besylate regular dose|DRUG: Atracurium Besylate minial dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The HepatoPancreaticoBiliary Resection Arginine Immunomodulation (PRIMe) Trial
Status: COMPLETED
Conditions: Hepatopancreaticobiliary (HPB) Malignancy|Surgery
Interventions: DIETARY_SUPPLEMENT: Active A|DIETARY_SUPPLEMENT: Active B|DIETARY_SUPPLEMENT: Lipid bolus|DIETARY_SUPPLEMENT: Placebo oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ultrasound Therapy on Bilateral Masseter Myalgia: Comparison of 1 Megahertz Versus 3 Megahertz
Status: COMPLETED
Conditions: Adult Females|Bilateral Masseter Myalgia
Interventions: PROCEDURE: Therapeutic ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Dorsolateral Prefrontal Cortex Transcranial Direct Current and Muscle Fatigue Stimulation on Muscle Fatigue
Status: ENROLLING_BY_INVITATION
Conditions: Fatigue
Interventions: DEVICE: transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DO IT Trial: Vitamin D Outcomes and Interventions In Toddlers
Status: COMPLETED
Conditions: Respiratory Tract Infections|Asthma|Avitaminosis
Interventions: DRUG: Vitamin D - Cholecalciferol 400 IU|DRUG: Vitamin D3 - Cholecalciferol 2000 IU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Stryker NTX Registry Scorpio NRG (Re-"Energize"), Triathlon Total Knee, Triathlon Partial Knee Resurfacing (PKR) With X3 Polyethylene Insert
Status: TERMINATED
Conditions: Arthroplasty, Replacement, Knee
Interventions: DEVICE: Triathlon Total Knee System with X3 insert|DEVICE: Scorpio NRG Total Knee System with X3 insert|DEVICE: Triathlon PKR System with X3 insert|PROCEDURE: Total Knee Replacement|PROCEDURE: Partial Knee Resurfacing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Impact of Vagus Nerve Stimulation on Diabetic Peripheral Neuropathic Pain
Status: COMPLETED
Conditions: Diabetes Mellitus|Diabetic Neuropathies|Type2diabetes|Neuropathic Pain
Interventions: DEVICE: non-invasive transcutaneous vagal nerve stimulation (tVNS)|DEVICE: Sham device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Adding Modified Ketogenic Diet to Exercise Program in Treating Obese Patient With Multiple Sclerosis: A Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis
Interventions: OTHER: Modified Ketogenic Diet|OTHER: exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Durvalumab Following Radiation Therapy in Patients With Stage 3 Unresectable NSCLC Ineligible for Chemotherapy
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Oxycodone on Individuals Taking an SSRI
Status: NOT_YET_RECRUITING
Conditions: Opioid Induced Respiratory Depression|Depressive Disorder|Anxiety Disorders
Interventions: DRUG: Oxycodone Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nivolumab Combined With BMS-986253 in HCC Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Nivolumab 240 mg IV every 2 weeks + Cabiralizumab 4 mg/kg IV every 2 weeks|DRUG: Nivolumab 240 mg IV every 2 weeks + BMS-986253 1200 mg IV every 2 weeks|DRUG: Nivolumab 240 mg IV every 2 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GEN-001 in Combination With Avelumab for Patients With PD-L1 Positive Gastric Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Cancer|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: GEN-001|DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Naltrexone in AUD Reward Drinkers
Status: RECRUITING
Conditions: Alcohol Use Disorder|Alcoholism
Interventions: DRUG: XR-NTX 380 mg, intramuscular injection|BEHAVIORAL: Medical Management|DRUG: Placebo intramuscular injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sublingual Sufentanil vs Intravenous Fentanyl for Acute Pain in the Ambulatory Surgery Center
Status: COMPLETED
Conditions: Pain|Pain, Acute|Anesthesia
Interventions: DRUG: Sublingual Sufentanil|DRUG: IV Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Power Training on Muscle Quality and Functional Capacity in Women Aged 65-75.
Status: UNKNOWN
Conditions: Muscle Weakness|Muscle Loss
Interventions: OTHER: Muscle power training with velocity loss (VL) of 10%|OTHER: Muscle power training with velocity loss (VL) of 30%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Natural Vascular Scaffold (NVS) Therapy for Treatment of Atherosclerotic Lesions (Activate I)
Status: COMPLETED
Conditions: Peripheral Arterial Disease|Peripheral Vascular Diseases|Catheterization, Peripheral
Interventions: COMBINATION_PRODUCT: NVS Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Steroid Replacement Therapy on Metabolic, Cardiovascular and Bone Outcomes in Adrenal Insufficiency
Status: COMPLETED
Conditions: Adrenal Insufficiency
Interventions: DRUG: dual-release hydrocortisone|DRUG: Conventional glucocortidois
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of NPC-22 in Healthy Adult Males
Status: COMPLETED
Conditions: Healthy Adult Subjects
Interventions: DRUG: NPC-22|DRUG: NPC-22|DRUG: NPC-22|DRUG: NPC-22|DRUG: NPC-22|DRUG: NPC-22 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparing Home, Office, and Telehealth Induction for Medication Assisted Treatment for Opioid Use Disorder
Status: ACTIVE_NOT_RECRUITING
Conditions: Opioid-use Disorder|Opioid Dependence
Interventions: BEHAVIORAL: Medication Assisted Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety and Biological Activity of ATYR1940 in Participants With Early Onset Facioscapulohumeral Muscular Dystrophy
Status: COMPLETED
Conditions: Facioscapulohumeral Muscular Dystrophy (FSHD)
Interventions: BIOLOGICAL: ATYR1940
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Quantum Dots (QD) for Advanced Retinitis Pigmentosa (RP) (QUANTUM)
Status: NOT_YET_RECRUITING
Conditions: Retinitis Pigmentosa
Interventions: DEVICE: 2C-QD|DEVICE: Sham 2C-QD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determine Whether Glycemic Control is Different Between Lantus & a 3rd Oral Agent When Failure With Other Treatment
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Lantus (insulin glargine [rDNA origin] injection)|DRUG: Metformin|DRUG: Glyburide|DRUG: Thiazolidinedione
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of VAL-083 in Patients With MGMT Unmethylated, Bevacizumab-naive Glioblastoma in the Adjuvant or Recurrent Setting
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioma|Glioblastoma|Glioblastoma Multiforme|GBM|Brain Cancer
Interventions: DRUG: VAL-083, Dianhydrogalactitol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Supplementation of Antioxidants (Vitamins E + C) Plus Omega-3 Fatty Acids
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: Olanzapine, Omega 3, Vitamin E+C
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: GSK BHR Study (Sont - Second Study)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Placebo|DRUG: Placebo|DRUG: FP 100mcg|DRUG: FP 250mcg|DRUG: FP 500mcg|DRUG: FSC 100/50mcg|DRUG: FSC 250/50mcg|DRUG: FSC500/50mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Proof -of -Concept Study To Stratify Targeted Therapies Adapted To Molecular Profiling
Status: UNKNOWN
Conditions: Relapsed or Refractory Pediatric Tumor
Interventions: PROCEDURE: biopsy or surgical resection of tumor and blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Evaluate Harm Reduction Products as a Second Line Intervention for Adult Smokers Who Do Not Quit With NRT
Status: ACTIVE_NOT_RECRUITING
Conditions: Smoking Cessation|Harm Reduction
Interventions: DRUG: Nicoderm|DRUG: Nicorette 4Mg Chewing Gum|DRUG: Nicorette Lozenge Product|OTHER: BIDI e-cigarette|OTHER: on!
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CC-11050 Trial in Nepalese Patients With Erythema Nodosum Leprosum
Status: RECRUITING
Conditions: Erythema Nodosum Leprosum|Leprosy
Interventions: DRUG: CC-11050
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Darunavir/r + Tenofovir/Emtricitabine vs. Darunavir/r + Raltegravir in HIV-infected Antiretroviral naïve Subjects
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: darunavir/ritonavir QD + raltegravir BID|DRUG: darunavir/r QD + tenofovir/emtricitabine QD (fixed dose combination)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Participants to Evaluate the Effect of JNJ-54175446 on Amyloid Biomarkers and Cytokine Profiles in Cerebrospinal Fluid and Plasma
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-54175446|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis Who Have an Inadequate Response to DMARDs or Anti-TNF
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tocilizumab [RoActemra/Actemra]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Flow Controlled Ventilation and Volume Controlled Ventilation
Status: RECRUITING
Conditions: Vocal Cord Disease|Vocal Cord Cyst
Interventions: PROCEDURE: Intubation|DEVICE: Flow Controlled Ventilation|DEVICE: Volume Controlled Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Salmon Peptide Fraction: Safety and Cardiometabolic Health
Status: ACTIVE_NOT_RECRUITING
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Supplement dose 15g/d|DIETARY_SUPPLEMENT: Supplement dose 7.5g/d
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Does Use of the Waterpik Maintain Cleaner Teeth in Patients With Fixed Braces
Status: TERMINATED
Conditions: Orthodontic Appliance Complication
Interventions: DEVICE: Waterpik
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 3 Efficacy and Safety Fixed-Dose Study in Pediatrics (6-17) With ADHD Using CTx-1301
Status: TERMINATED
Conditions: ADHD|Attention Deficit Hyperactivity Disorder|ADHD - Combined Type|Attention Deficit Hyperactivity Disorder Combined|Attention-deficit Hyperactivity|Attention Deficit Hyper Activity
Interventions: DRUG: CTx-1301-Dexmethylphenidate 12.5 mg (titration only)|DRUG: CTx-1301-Dexmethylphenidate 18.75mg (randomized fixed dose)|DRUG: CTx-1301-Dexmethylphenidate 25mg (randomized fixed dose)|DRUG: CTx-1301-Dexmethylphenidate 37.5 mg (randomized fixed dose)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Iron Bioavailability of Fortified Oat Drink
Status: COMPLETED
Conditions: Iron Absorption
Interventions: OTHER: Dietary Intervention (with Vit C then without Vit C)|OTHER: Dietary Intervention (without Vit C followed by with Vit C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Speech Intelligibility and Cognition: Are Inpatients Impaired by Noise?
Status: COMPLETED
Conditions: Auditory Perception|Memory|Hearing Impairment
Interventions: OTHER: quiet|OTHER: non-speech noise|OTHER: speech noise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Economic Incentives and vDOT for Latent Tuberculosis Infection
Status: RECRUITING
Conditions: Latent Tuberculosis
Interventions: BEHAVIORAL: Usual Care|BEHAVIORAL: Video Directly Observed Therapy alone|BEHAVIORAL: Video Directly Observed Therapy plus Financial Incentives
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study Evaluating the Long Term Safety and Efficacy of VX-659 Combination Therapy
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DRUG: VX-659/TEZ/IVA|DRUG: IVA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Interactions of Amprenavir and Efavirenz, in Combination With a Second Protease Inhibitor, in HIV-Negative Volunteers
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Ritonavir|DRUG: Amprenavir|DRUG: Nelfinavir mesylate|DRUG: Efavirenz|DRUG: Saquinavir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Treatment Study of Negative Pressure Wound Therapy for Diabetic Foot Wounds
Status: COMPLETED
Conditions: Foot Ulcer, Diabetic
Interventions: DEVICE: Negative Pressure Wound Therapy|OTHER: Standard Wound Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multinational Study Comparing the Long-term Efficacy and Safety of Two Medicines, Solifenacin Succinate and Mirabegron Taken Together, or Separately, in Subjects With Symptoms of Overactive Bladder
Status: COMPLETED
Conditions: Urinary Bladder Overactive|Overactive Bladder|Urgency Incontinence|Urinary Bladder Diseases\Urologic Diseases
Interventions: DRUG: Solifenacin succinate|DRUG: Mirabegron|DRUG: Placebo to match solifenacin|DRUG: Placebo to match mirabegron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of Fallot and Other Congenital Heart Diseases
Status: RECRUITING
Conditions: Tetralogy of Fallot|Congenital Heart Disease
Interventions: DIAGNOSTIC_TEST: Remote Heart Rhythm Monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized, Parallel Arm, Comparative, Open Label, Multicenter Study of the Activity and Safety of Two Formulations of Saquinavir in Combination With Other Antiretroviral Drugs
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Saquinavir|DRUG: Lamivudine|DRUG: Stavudine|DRUG: Zidovudine|DRUG: Zalcitabine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparison of DHT Duration in Geriatric Patients Using BIS Monitoring
Status: COMPLETED
Conditions: Deep Hypnotic Time|Emergence Time|Geriatric Population|General Anesthesia
Interventions: OTHER: Bispectral index monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cyclophosphamide Versus Mycophenolate Mofetil for the Treatment of Steroid-dependent Nephrotic Syndrome in Children
Status: COMPLETED
Conditions: Idiopathic Nephrotic Syndrome
Interventions: DRUG: Cyclophosphamide|DRUG: Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AMX0035 and Progressive Supranuclear Palsy
Status: RECRUITING
Conditions: Progressive Supranuclear Palsy|PSP|Neurodegenerative Diseases|Atypical Parkinsonism
Interventions: DRUG: AMX0035|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Propofol on Postoperative Sleep Quality in Elderly Patients With Sleep Disorders
Status: UNKNOWN
Conditions: Sleep Disorder
Interventions: DRUG: Propofol|DRUG: Dexmedetomidine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Lymphocytic Infiltrate, Dendritic Cells and Cytokines Expression in Psoriatic Lesion and Normal Skin Before and After TNF Alfa Inhibitors Therapy
Status: UNKNOWN
Conditions: Moderate to Severe Psoriasis.|Absolute Number, Density of Immune Infiltrate and Dendritic Cells and Inflammatory Cytokines Expression Pattern.
Interventions: DRUG: Adalimumab, etanercept, infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An up to Twelve Week Safety and Efficacy Study With a Topical Gel to Treat Common Warts in Pediatric Subjects
Status: COMPLETED
Conditions: Warts
Interventions: DRUG: Resiquimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Development and Feasibility of an Internet Intervention for Adults With Spinal Cord Injury to Prevent Pressure Ulcers
Status: COMPLETED
Conditions: Spinal Cord Injury|Pressure Ulcers
Interventions: BEHAVIORAL: iSHIFTup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bortezomib, Selinexor, and Dexamethasone in Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Selinexor|DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Whey Protein Supplement in Combination With Physical Exercise and Nutrition Program
Status: COMPLETED
Conditions: Lung Cancer|Gastro-Intestinal Cancer|Breast Cancer|Prostate Cancer|Pleural Mesothelioma|Urothelial Carcinoma|Renal Cell Carcinoma|Ovarian Cancer
Interventions: BEHAVIORAL: physical exercise|BEHAVIORAL: nutrition counseling|DIETARY_SUPPLEMENT: whey protein supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of a Low Fiber Diet for Pediatric Colonoscopy Prep
Status: ENROLLING_BY_INVITATION
Conditions: Colitis|Gastrointestinal Diseases|Pediatric Disorder|Pediatric Crohns Disease|Procedural Sequelae
Interventions: DIETARY_SUPPLEMENT: Low fiber diet|DIETARY_SUPPLEMENT: Standard clear liquid diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Readiness and Motivation Therapy in Individuals With Anorexia Nervosa and Bulimia Nervosa
Status: UNKNOWN
Conditions: Anorexia Nervosa|Bulimia Nervosa
Interventions: BEHAVIORAL: Readiness and Motivation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Eye Movement Tracking to Detect Oculomotor Abnormality in Traumatic Brain Injury Patients
Status: COMPLETED
Conditions: Brain Concussion|Cerebral Concussion|Concussion, Intermediate|Concussion, Mild|Concussion, Severe|Trauma, Nervous System|Craniocerebral Trauma|Brain Injuries
Interventions: DEVICE: EyeBox CNS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 3 Study to Evaluate the Efficacy & Safety of Self-Administered Injections of BMN165 by Adults With PKU
Status: COMPLETED
Conditions: Phenylketonuria (PKU)
Interventions: DRUG: BMN165 20mg/day|DRUG: BMN165 40mg/day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Strategy for Aortic Surgery Hemostasis
Status: UNKNOWN
Conditions: Ascending Aorta Abnormality|Ascending Aortic Dissection|Ascending Aorta Aneurysm
Interventions: COMBINATION_PRODUCT: TDM-621
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GSK1120212 vs Chemotherapy in Advanced or Metastatic BRAF V600E/K Mutation-positive Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: GSK1120212|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Collected Data of Medical Food, Vasculera or Diosmiplex, in Clinic Patients 20 to 70 Years Old Diagnosed With Lipedema
Status: COMPLETED
Conditions: Lipedema
Interventions: DIETARY_SUPPLEMENT: Diosmiplex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn How Safe and Tolerable Odronextamab and Cemiplimab Are in Adult Patients With B-cell Malignancies
Status: RECRUITING
Conditions: Relapsed/Refractory Aggressive B-Cell Lymphoma
Interventions: DRUG: cemiplimab|DRUG: odronextamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibrutinib in Treating Patients With Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia
Status: TERMINATED
Conditions: Adult B Acute Lymphoblastic Leukemia|Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1|Recurrent Adult Acute Lymphoblastic Leukemia
Interventions: DRUG: Ibrutinib|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Health and Exercise Response in Children With Chronic and Auto-immune Pathologies
Status: RECRUITING
Conditions: Juvenile Idiopathic Arthritis|Diabetes|Inflammatory Bowel Disease|Cancer Survivor|Anorexia Nervosa
Interventions: OTHER: indirect calorimetry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Norwegian Stepped-Care TF-CBT Study
Status: COMPLETED
Conditions: Post Traumatic Stress Disorder (PTSD)|Depressive Symptoms|Parental Stress|Health Related Quality of Life
Interventions: OTHER: Stepped-Care TF-CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin for Erectile Dysfunction
Status: COMPLETED
Conditions: Sexual Dysfunction|Erectile Dysfunction
Interventions: DRUG: Botulinum Toxin Type A|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of Durvalumab Alone or Chemotherapy for Patients With Advanced Non Small-Cell Lung Cancer (PEARL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Carcinoma NSCLC
Interventions: DRUG: Durvalumab (MEDI4736)|DRUG: Paclitaxel + carboplatin|DRUG: Gemcitabine + cisplatin|DRUG: Gemcitabine + carboplatin|DRUG: Pemetrexed + cisplatin|DRUG: Pemetrexed + carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound arteriaL Stiffness evaluatIon and vaScular Complications in Patients Undergoing Transfemoral tranScatheter Aortic valvE Implantation: ULISSE Study.
Status: UNKNOWN
Conditions: Transfemoral tranScatheter Aortic valvE Implantation
Interventions: PROCEDURE: Transfemoral tranScatheter aortic valvE implantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Non-therapeutic Feasibility Study of the Radioligand [11C]-UCB-J for Imaging Synaptic Density
Status: COMPLETED
Conditions: Healthy|Alzheimer Disease
Interventions: OTHER: [11C]-UCB-J
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Autogene Cevumeran (RO7198457) as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma|Non-Small Cell Lung Cancer|Bladder Cancer|Colorectal Cancer|Triple Negative Breast Cancer|Renal Cancer|Head and Neck Cancer|Other Solid Cancers
Interventions: DRUG: Autogene cevumeran|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Study to Evaluate the Safety of UB-421 in Combination With Antiretroviral Therapy (ART) and the Efficacy in Reduction of HIV Viral Load and Proviral DNA as Compared to ART Alone in ART-experienced Viremic HIV-1 Patients
Status: WITHDRAWN
Conditions: HIV-1 Infection
Interventions: BIOLOGICAL: UB-421|OTHER: Antiretroviral Therapy (ART)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atacicept in Multiple Sclerosis Extension Study, Phase II
Status: TERMINATED
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: Atacicept 25 mg|DRUG: Atacicept 75 mg|DRUG: Atacicept 150 mg|DRUG: Atacicept 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture Therapy Combined With Breathing Training for Patients With Stroke Complicated
Status: COMPLETED
Conditions: Stroke|Lung Diseases
Interventions: DEVICE: TCM acupuncture therapy|DRUG: Conventional drug therapy|BEHAVIORAL: Rehabilitation therapy|BEHAVIORAL: Breathing training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE