pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Early Chair Sitting Exercise in Mechanically Ventilated Critically Ill Patients
Status: TERMINATED
Conditions: Chronic Respiratory Failure With Acute Decompensation Requiring Mechanical Ventilation for More Than 48 Hours
Interventions: PROCEDURE: Early chair sitting exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Paclitaxel for the Treatment of Gastric or Gastroesophageal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Clinical Stage IV Gastric Cancer AJCC v8|Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IVA Gastric Cancer AJCC v8|Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IVB Gastric Cancer AJCC v8|Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8|Metastatic Gastric Adenocarcinoma|Metastatic Gastroesophageal Junction Adenocarcinoma|Pathologic Stage IV Gastric Cancer AJCC v8|Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8|Peritoneal Carcinomatosis|Postneoadjuvant Therapy Stage IV Gastric Cancer AJCC v8|Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
Interventions: DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Exploring Efficacy and Safety of Amlodipine in the Stented Angina Patients
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Placebo|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: NO During CPB in Neonates to Reduce Risk of AKI
Status: RECRUITING
Conditions: AKI|CHD - Congenital Heart Disease|Surgery
Interventions: DRUG: Nitric Oxide|DRUG: Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Recovery Initiation and Management After Overdose (RIMO) Experiment
Status: ACTIVE_NOT_RECRUITING
Conditions: Opioid-use Disorder
Interventions: BEHAVIORAL: Recovery Initiation and Management after Overdose (RIMO)|OTHER: Passive Referral to Treatment Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Assessment Metabolic Flexibility in Middle-aged Individuals: The Nutritional Impact of Cheese Consumption
Status: RECRUITING
Conditions: Metabolism|Nutrition
Interventions: DIETARY_SUPPLEMENT: kent'erbas cheese study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Analgesic and Anti-hyperalgesic Effect of Opioids in Experimental Pain
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Buprenorphine|DRUG: Fentanyl|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Safety and Tolerance of Increased Doses of HRS-5346 Tablets in Healthy Subjects
Status: RECRUITING
Conditions: Lipoprotein Disorder Disease
Interventions: DRUG: HRS-5346 tablets|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of TAK-438 in Healthy Male Participants
Status: COMPLETED
Conditions: Ascending Single Dose Study
Interventions: DRUG: TAK-438|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Camrelizumab in Combination With Apatinib in Patients With Radioactive Iodine-refractory Differentiated Thyroid Cancer
Status: RECRUITING
Conditions: Radioactive Iodine-refractory Differentiated Thyroid Cancer
Interventions: DRUG: Camrelizumab combination with Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Self-adhering Material in Dental Hypersensitivity
Status: COMPLETED
Conditions: Dentin Sensitivity|Xerostomia
Interventions: OTHER: Veritise Flow|OTHER: Universal Dentin Sealant|OTHER: Clearfil Protect Bond|OTHER: Flor-Opal® Varnish
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1, First-in-Human Study of RAD140 in Postmenopausal Women With Breast Cancer
Status: COMPLETED
Conditions: Hormone Receptor Positive Malignant Neoplasm of Breast
Interventions: DRUG: RAD140
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Fatty Acids Plus Vitamin E Cosupplementation Versus Vitamin E in Fibrocystic Breast Patient
Status: UNKNOWN
Conditions: Mastalgia
Interventions: DRUG: Omega 3 fatty acid|DRUG: VitaE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trametinib With GSK2141795 in BRAF Wild-type Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Trametinib (GSK1120212)|DRUG: GSK2141795
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: APAF: Assessment of Cardiac Resynchronization Therapy in Patients With Permanent Atrial Fibrillation
Status: COMPLETED
Conditions: Congestive Heart Failure|Atrial Fibrillation
Interventions: OTHER: Optimized echo-guided CRT pacing|OTHER: normal RV pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Donepezil on Regional Cerebral Blood Flow Following Aneurysmal Subarachnoid Haemorrhage
Status: TERMINATED
Conditions: Aneurysmal Subarachnoid Hemorrhage|Delayed Neurological Deficit|Delayed Cerebral Ischemia|Vasospasm
Interventions: DRUG: Donepezil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Stability and Cost-Effectiveness of 3 Bicortical Screws Vs Adjustable Plate and 2 Bicortical Screws in Fixation of BSSRO
Status: COMPLETED
Conditions: Mandibular Hypoplasia
Interventions: DEVICE: 3 bicortical screws|DEVICE: adjustable plate and 2 bicortical screws
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Minocycline as Adjunctive Treatment for Treatment Resistant Depression
Status: RECRUITING
Conditions: Treatment Resistant Depression
Interventions: DRUG: Minocycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase Ib Trial of Infigratinib In Combination With Atezolizumab And Bevacizumab for The Second-Line Treatment of Advanced Cholangiocarcinoma With FGFR2 Fusion/Amplification
Status: WITHDRAWN
Conditions: Cholangiocarcinoma|Liver Cancer
Interventions: DRUG: Infigratinib|DRUG: Atezolizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment With AKL1 in Obstructive Airways Disease (The TAKL Study)
Status: UNKNOWN
Conditions: Obstructive Lung Disease|Chronic Obstructive Pulmonary Disease|Asthma
Interventions: DIETARY_SUPPLEMENT: AKL1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electric Stimulation of the Eye to Improve Vision After Trauma
Status: COMPLETED
Conditions: Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)|Trauma|Multiple Sclerosis (MS)
Interventions: DEVICE: Transcorneal Electrical Stimulation|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TEAM (Trial on Efficacy and Quality of Life Among Asthmatic Patient With Montelukast)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Montelukast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of Intravenous COVI-MSC for Treatment of COVID-19-Induced Acute Respiratory Distress
Status: TERMINATED
Conditions: Covid19
Interventions: BIOLOGICAL: COVI-MSC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Canakinumab in the Treatment of Gouty Arthritis Flare(s) and Prevention of New Flares in Patients With Chronic Kidney Disease
Status: WITHDRAWN
Conditions: Acute Gouty Arthritis
Interventions: DRUG: ACZ885|DRUG: Triamcinelone acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Clinical Equivalence of Two Mometasone Nasal Sprays in the Relief of the Signs and Symptoms of Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal
Interventions: DRUG: Mometasone furoate 50 mcg/actuation nasal spray (Lek Pharmaceuticals)|DRUG: Mometasone furoate (Nasonex®) 50 mcg/actuation nasal spray|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development and Validation of the Prediction Model for Functional Mitral Regurgitation Regression in Heart Failure Patients Taking Guideline-directed Medical Therapy
Status: RECRUITING
Conditions: Mitral Regurgitation|Heart Failure
Interventions: DRUG: angiotensin-converting enzyme inhibitors/angiotensin II receptor blocker/angiotensin receptor-neprilysin inhibitor|OTHER: The development of the prediction model
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Orthokine Therapy in Lumbar Degenerative Disease
Status: UNKNOWN
Conditions: Degenerative Disc Disease|Lumbar Region
Interventions: PROCEDURE: Orthokine periradicular injection|PROCEDURE: Orthokine epidural injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Lowest Threshold of Vascular Benefits From LDL Cholesterol Lowering in Patients With Stable CV Disease
Status: UNKNOWN
Conditions: Atherosclerosis|Cardiovascular Diseases
Interventions: DRUG: Alirocumab 150 MG/ML|DRUG: Ezetimibe 10Mg Tablet|DRUG: Atorvastatin 40Mg Tablet|DRUG: Atorvastatin 80Mg Tablet|DRUG: Rosuvastatin 20Mg Tablet|DRUG: Rosuvastatin 40Mg Tablet|DRUG: Simvastatin 80mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Eggs and Egg Components on Cognitive Performance and Appetite in School-aged Children
Status: COMPLETED
Conditions: Nutrition|Cognitive Performance|Appetite
Interventions: OTHER: Snack skipping|OTHER: Whole eggs|OTHER: Egg whites|OTHER: Egg yolks|OTHER: Yogurt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA
Status: RECRUITING
Conditions: Anesthesia, Spinal|Arthroplasty, Replacement, Knee
Interventions: DRUG: Mepivacaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of the Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 Origins
Status: NOT_YET_RECRUITING
Conditions: Hyperpigmentation
Interventions: OTHER: tested product
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical, Neurocognitive, and Emotional Effects of Psilocybin in Depressed Patients - Proof of Concept
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Psilocybine oral capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Riboflavin Corneal Crosslinking for Brittle Cornea Syndrome and Ehlers-Danlos Syndrome Type VI
Status: UNKNOWN
Conditions: Brittle Cornea Syndrome|Ehlers-Danlos Syndrome Type 6
Interventions: DRUG: Riboflavin|DEVICE: Kera-X
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Pycnogenol on Cardiac Fibrosis and Diastolic Dysfunction in Aged Hypertensive Subjects
Status: TERMINATED
Conditions: Cardiac Fibrosis|Diastolic Dysfunction
Interventions: DIETARY_SUPPLEMENT: Pycnogenol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Glycaemic Control in Type 2 Diabetes Patients After Bariatric Surgery; ECODABS
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2 in Obese
Interventions: PROCEDURE: Roux-en-Y gastric bypass|PROCEDURE: Sleeve gastrectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Study of R744 to Predialysis Patients( Phase III, Comparative Study in Comparison With Epoetin Beta)
Status: COMPLETED
Conditions: Predialysis Patients
Interventions: DRUG: R744|DRUG: Epoetin beta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Staining Beverage on Color Alteration During In-office Tooth Bleaching
Status: COMPLETED
Conditions: Tooth Discoloration
Interventions: BEHAVIORAL: making staining beverage rinse during in-office tooth bleaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Tolerability of Ferric Citrate in Children With Hyperphosphatemia Related to Chronic Kidney Disease
Status: RECRUITING
Conditions: Hyperphosphatemia Related to Chronic Kidney Disease
Interventions: DRUG: ferric citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chest Shielding in Premature Infants During Phototherapy
Status: COMPLETED
Conditions: Patent Ductus Arteriosus in Premature Infants
Interventions: DEVICE: Chest shield with aluminum foil (CALF)|DEVICE: SHIELD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Revaccination With PPS23 Boosted or Not by PCV13 in Splenectomised Patients.
Status: ACTIVE_NOT_RECRUITING
Conditions: Splenectomised Patients
Interventions: BIOLOGICAL: Prevenar13 (PCV13) and Pneumovax (PPS23)|BIOLOGICAL: Placebo / Pneumovax (PPS23)|BIOLOGICAL: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder
Status: NOT_YET_RECRUITING
Conditions: Cocaine Use Disorder
Interventions: DRUG: Sustained-release Dexamphetamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Pain Neuroscience Education and Virtual Reality in Patients With Chronic Low Back Pain
Status: NOT_YET_RECRUITING
Conditions: Chronic Low-back Pain
Interventions: OTHER: Pain Neuroscience Education + Virtual Reality + Therapeutic Exercise|OTHER: Therapeutic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NEWTON: Aflibercept Injection for Previously Treated Macular Edema Associated With Central Retinal Vein Occlusions
Status: COMPLETED
Conditions: Macular Edema With Central Retinal Vein Occlusions
Interventions: DRUG: Aflibercept (2.0 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SAL067 Treatment in Patients With Type 2 Diabetes Who Are Not Controlled by Metformin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: SAL067|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Histopathological Findings in Symptomatizing Patients After Supracervical Hysterectomy
Status: COMPLETED
Conditions: CIN|Cancer of Cervix|Cervicitis
Interventions: PROCEDURE: Cervical biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Basimglurant (NOE-101) in Children, Adolescents, and Young Adults With TSC
Status: ACTIVE_NOT_RECRUITING
Conditions: Tuberous Sclerosis Complex
Interventions: DRUG: Basimglurant with crossover to Placebo|DRUG: Placebo with crossover to Basimglurant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cholangioscopy Using Narrow Band Imaging (NBI) in Patients With Primary Sclerosing Cholangitis (PSC) Undergoing Endoscopic Retrograde Cholangiopancreatogram (ERCP)
Status: COMPLETED
Conditions: Primary Sclerosing Cholangitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of HS-10518 in Healthy Female Participants
Status: NOT_YET_RECRUITING
Conditions: Endometriosis
Interventions: DRUG: HS-10518|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Safety of Live Intranasal Sendai Virus Vaccine in Children and Toddlers
Status: SUSPENDED
Conditions: Parainfluenza|Respiratory Viral Infections
Interventions: BIOLOGICAL: Sendai virus vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Vascepa on Improving Coronary Atherosclerosis in People With High Triglycerides Taking Statin Therapy
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DRUG: Vascepa|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Animal Assisted Activity to Elderly
Status: NOT_YET_RECRUITING
Conditions: Old Age; Debility|Nursing Home|Loss of Interest in Activities|Loneliness|Depression
Interventions: BEHAVIORAL: Animal assisted activity
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Sensitizing Potential of MOB015B in Healthy Subjects Using a Repeat Insult Patch Test Design
Status: COMPLETED
Conditions: Erythema
Interventions: DRUG: MOB015B|DRUG: MOB015B vehicle|DRUG: Negative irritant solution of 0.9% saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Rotational Stability of Acrysof IQ Vivity Extended Vision Toric IOL and Refractive Visual Outcome.
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Alcon Vivity toric intra ocular lens
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MIDNOR-STROKE- a Long Term Follow-up Study of Patients With First Ever Ischemic Stroke in Central Norway
Status: ACTIVE_NOT_RECRUITING
Conditions: Stroke|Cardiovascular Diseases|Cardiovascular Risk Factor|Brain Ischemia|Cerebrovascular Disorders|Nervous System Diseases|Central Nervous System Lymphoma|Pathologic Processes|Vascular Diseases
Interventions: OTHER: no intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Mobile Application on Supportive Care Needs and Quality of Life Patients Undergoing Hematopoietic Stem Cell Transplantation
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematologic Malignancy|Patient Education
Interventions: OTHER: mobile application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of AQW051 on Cognitive Function in Patients With Chronic Stable Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia Disorders
Interventions: DRUG: Placebo (single and multiple doses)|DRUG: AQW051 2 mg (single and multiple doses)|DRUG: AQW051 15mg (single and multiple doses)|DRUG: AQW051 100mg (single dose), and 50mg (multiple doses)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Detection and Prevalence of Human Papillomavirus (HPV) in Seminal Plasma and/or on Sperm in Men Undergoing Treatment With IVF/ICSI.
Status: COMPLETED
Conditions: Human Papilloma Virus|Infertility, Male
Interventions: OTHER: HPV exposure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Noninvasive High Frequency Oscillatory Ventilation as a Post-extubation Respiratory Support in Neonates
Status: UNKNOWN
Conditions: Infant, Premature, Diseases|Infant, Newborn, Disease|Respiratory Tract Diseases|RDS
Interventions: DEVICE: noninvasive high frequency oscillatory ventilation|DEVICE: noninvasive positive pressure ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lymphatic Response to Resistance Exercise in Breast Cancer Survivors
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer Lymphedema|Survivorship|Lymphedema of Upper Limb
Interventions: OTHER: Resistance Therapeutic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing Different Single and Combination Chelating Agents on Sealer Penetration and Dentin Erosion.
Status: COMPLETED
Conditions: Root Canal Infection|Periapical Abscess|Irreversible Pulpitis|Apical Periodontitis
Interventions: DRUG: Ethylene Diamine Tetra Acetic acid|DRUG: smearOFF|DRUG: Etidronic acid /sodium hypochlorite|DRUG: Maleic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment
Status: RECRUITING
Conditions: Apathy|Mild Cognitive Impairment|Transcranial Magnetic Stimulation|Loneliness|COVID|Neuropsychiatric Symptoms
Interventions: DEVICE: Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Brinzolamide and Timolol When Added to Travoprost in Primary Open-angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Primary Open-angle Glaucoma|Ocular Hypertension|Pigment Dispersion Glaucoma
Interventions: DRUG: Brinzolamide 1% added to Travoprost 0.004%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Iron for Iron-deficiency Anemia in Pregnancy: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Iron Deficiency Anemia of Pregnancy|Iron Malabsorption
Interventions: DRUG: Iron dextran|DRUG: Ferrous sulfate 325mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A New Approach to Deliver Malaria Preventions to Pregnant Women at a Community Level in Uganda
Status: COMPLETED
Conditions: Malaria|Pregnancy|Anemia
Interventions: DRUG: sulphadoxine-pyrimethamine intermittent preventive treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Single-cell Approach to Identify Biomarkers of Pulmonary Toxicity for Immune Checkpoint Blockade
Status: RECRUITING
Conditions: Pneumonitis, Interstitial|Immunotherapy|Immune-related Adverse Events
Interventions: DRUG: Immune checkpoint blockade|DRUG: Targeted therapy|RADIATION: Radiotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment I(2) - 2
Status: WITHDRAWN
Conditions: Heroin Dependence|Opioid-Related Disorders
Interventions: DRUG: Heroin Dependence
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Additional MDMA-assisted Therapy for People Who Relapsed After MDMA-assisted Therapy Trial
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: Midomafetamine|BEHAVIORAL: Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Progressive Relaxation Exercises on Anxiety, Satisfaction and Stress Levels Before Simulation Education
Status: NOT_YET_RECRUITING
Conditions: Anxiety|Stress|Satisfaction|Relaxation; Joint, Congenital|Simulation
Interventions: BEHAVIORAL: Progressive Relaxation Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Developing a Tailored Stigma Reduction Intervention to Increase Buprenorphine Prescribing
Status: RECRUITING
Conditions: Opioid-Related Disorders|Buprenorphine|Social Stigma|Rural Health Services
Interventions: BEHAVIORAL: Stigma-reduction training|BEHAVIORAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Reducing Internalized Stigma in People With Serious Mental Illness
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Bipolar Disorder|Major Depression With Psychotic Features
Interventions: BEHAVIORAL: Ending Self Stigma (ESS)|BEHAVIORAL: Health and Wellness Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effectiveness of Incentive Spirometry
Status: COMPLETED
Conditions: Dyspnea|Respiratory Rate|Oxygen Saturation|Oxygen Requirements|FEV1|FVC|Atelectasis|Pneumonia|Re-intubation|Hospital Length of Stay|Nursing Workload|Incentive Spirometry
Interventions: BEHAVIORAL: Use-recording, patient-reminder alarm for incentive spirometry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant ADI-PEG 20 + Ifosfamide + Radiotherapy in Soft Tissue Sarcoma
Status: RECRUITING
Conditions: Soft Tissue Sarcoma|Sts|Sarcoma,Soft Tissue
Interventions: DRUG: ADI PEG20|DRUG: Ifosfamide|RADIATION: Radiotherapy|DRUG: Mesna
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study To Assess The Impact Of Hepatic Impairment On The Safety, Tolerability And Pharmacokinetics Of Single-Dose 200 Mg Of PF-868554
Status: COMPLETED
Conditions: HEPATITIS C (HCV)
Interventions: DRUG: PF-868554|DRUG: PF-868554|DRUG: PF-868554
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simple Initiation of Advanced Hybrid Closed Loop System
Status: COMPLETED
Conditions: Diabetes type1
Interventions: PROCEDURE: Regular Protocol with advanced carbohydrate counting|PROCEDURE: Simplified Protocol with fixed carbohydrate content
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of Gemcitabine, Nab-paclitaxel, Capecitabine, Cisplatin, and Irinotecan in Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Adenocarcinoma|Pancreatic Neoplasms|Neoplasm, Glandular|Neoplasms|Neoplasms Pancreatic|Digestive System Neoplasm|Endocrine Gland Neoplasms|Digestive System Disease|Pancreatic Diseases|Endocrine System Diseases
Interventions: DRUG: Nab-paclitaxel|DRUG: Gemcitabine|DRUG: Capecitabine|DRUG: Cisplatin|DRUG: Irinotecan|DRUG: Nab-paclitaxel|DRUG: Gemcitabine|DRUG: Capecitabine|DRUG: Cisplatin|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Animal Assisted Activity on Biobehavioral Stress Responses of Hospitalized Children: A Randomized Control Trial
Status: COMPLETED
Conditions: Psychosocial Stress
Interventions: BEHAVIORAL: Therapy dog visitation (TDV)|BEHAVIORAL: non-TDV control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Video-based Health Education on Maternal and Child Health in Ethiopia
Status: COMPLETED
Conditions: Anemia|Antenatal Care|Birth Outcomes|Worm Infection|Bacterial Vaginoses|Exclusive Breastfeeding
Interventions: BEHAVIORAL: Standard counselling|BEHAVIORAL: Health-Video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Efficacy and Safety of Satralizumab in FSHD1
Status: RECRUITING
Conditions: Facioscapulohumeral Muscular Dystrophy 1
Interventions: DRUG: Satralizumab Prefilled Syringe|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Followed By Antiviral Therapy and Interferon Alfa in Treating Patients With HTLV-1-Related Adult T-Cell Leukemia/Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: recombinant interferon alfa|DRUG: Etoposide|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: lamivudine|DRUG: prednisone|DRUG: vincristine sulfate|DRUG: zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Offset of Ticagrelor's Effect on Endothelial Function as Assessed With Peripheral Arterial Tonometry (EndoPAT Assay)
Status: COMPLETED
Conditions: Coronary Artery Disease|Endothelial Function
Interventions: DEVICE: Peripheral arterial tonometry (EndoPAT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Relative Bioavailability and Tolerability of Bimekizumab in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Bimekizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Alogliptin Combined With Pioglitazone in Treating Subjects With Type 2 Diabetes Mellitus.
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Alogliptin|DRUG: Alogliptin placebo|DRUG: Pioglitazone|DRUG: Pioglitazone placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reveal® XT Performance Trial (XPECT)
Status: COMPLETED
Conditions: Atrial Fibrillation|Risk of Cardiac Arrhythmias
Interventions: OTHER: 46 hrs Holter ECG recording
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Cost Effectiveness Analysis In Patients With Heart Valve Prosthesis
Status: UNKNOWN
Conditions: Complications Due to Heart Valve Prosthesis
Interventions: DRUG: Acetyl Salicylic Acid|DRUG: Warfarin|DRUG: Placebo (for Aspirin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Enzalutamide and Paclitaxel Before Surgery in Treating Patients With Stage I-III Androgen Receptor-Positive Triple-Negative Breast Cancer
Status: COMPLETED
Conditions: Invasive Breast Carcinoma|Stage I Breast Cancer AJCC v7|Stage IA Breast Cancer AJCC v7|Stage IB Breast Cancer AJCC v7|Stage II Breast Cancer AJCC v6 and v7|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7|Stage III Breast Cancer AJCC v7|Stage IIIA Breast Cancer AJCC v7|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7|Triple-Negative Breast Carcinoma
Interventions: PROCEDURE: Axillary Lymph Node Dissection|DRUG: Enzalutamide|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Lymph Node Biopsy|DRUG: Paclitaxel|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclosporine Dose Adjustment According to Calcineurin Activity After Allogeneic Hematopoietic Stem-cell Transplantation
Status: COMPLETED
Conditions: Hematopoietic Stem Cell Transplantation|Graft Versus Host Disease
Interventions: BEHAVIORAL: Dose adaptation according to CN activity monitoring|DRUG: Cyclosporine (CsA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety of Vero Cell - Derived Inactivated Japanese Encephalitis Vaccine (JECEVAX) in Children From 9-24 Months of Age
Status: COMPLETED
Conditions: Japanese Encephalitis
Interventions: BIOLOGICAL: JEVAX|BIOLOGICAL: JECEVAX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oxycodone/Naloxone (OXN) Combination in Moderate to Severe Non-malignant Pain
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Oxycodone hydrochloride and naloxone hydrochloride combination, prolonged release
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Versus Neoadjuvant Plus Adjuvant Chemotherapy in Resectable Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: Neoadjuvant Chemotherapy with gemcitabine/oxaliplatin|DRUG: adjuvant chemotherapy with gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation Between Surgical Therapy of Lipedema Compared to Complex Physical Decongestive Therapy (CDT) Alone
Status: ACTIVE_NOT_RECRUITING
Conditions: Lipedema
Interventions: PROCEDURE: Liposuction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Methyldopa on Uterine Artery Diameter in Pregnant Women With Mild Preeclampsia
Status: COMPLETED
Conditions: Pregnant Women With Mild Preeclampsia
Interventions: DRUG: Methyldopa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Coenzyme A and Fenofibrate for Safety and Efficacy On Patients With Hyperlipidemia
Status: COMPLETED
Conditions: Hyperlipoproteinemia
Interventions: DRUG: Coenzyme A|DRUG: Fenofibrate 200mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hematopoietic Stem Cell Transplantation for Treatment of Patients With Fanconi Anemia Lacking a Genotypically Identical Donor, Using Total Body Irradiation, Cyclophosphamide and Fludarabine
Status: COMPLETED
Conditions: Fanconi Anemia
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|RADIATION: Total body irradiation (TBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brazilian Cardioprotective Diet and Nuts in Post-acute Myocardial Infarction
Status: COMPLETED
Conditions: Coronary Artery Disease|Myocardial Infarction
Interventions: DIETARY_SUPPLEMENT: Brazilian cardioprotective diet|DIETARY_SUPPLEMENT: Brazilian cardioprotective diet plus 30g/day of mixed nuts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-Based Cognitive Behavior Therapy for Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: BEHAVIORAL: Mindfulness-Based Cognitive Behavioral Therapy or Supportive Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neurocognition, Lifestyle Modification, and Treatment Resistant Hypertension
Status: COMPLETED
Conditions: Treatment-Resistant Hypertension
Interventions: BEHAVIORAL: Structured center-based lifestyle intervention|BEHAVIORAL: Standard education and physician advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Experimental Drug BKM120 With Paclitaxel in Patients With HER2 Negative, Locally Advanced or Metastatic Breast Cancer, With or Without PI3K Activation
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Paclitaxel|DRUG: BKM120 matching placebo|DRUG: BKM120
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Of Safety, Tolerability And Effects Of PF-05175157 In Adults With Moderate To Severe Acne Vulgaris
Status: WITHDRAWN
Conditions: Acne Vulgaris
Interventions: DRUG: PF-05175157|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of GS-5745 (Andecaliximab) in Adults With Moderate to Severe Active Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Andecaliximab|DRUG: Placebo to match Andecaliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Green Tea or Cocoa Extracts in Endothelial Dysfunction in Patients With Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus|Diabetic Nephropathy|Arterial Hypertension
Interventions: OTHER: green tea extract|OTHER: cocoa extract rich in polyphenols|OTHER: placebo|OTHER: low polyphenol cocoa extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Beta-alanine Supplementation and Its Effects on Performance, Muscle Carnosine Content and Safety in Athletes With Spinal-cord Injury
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: DIETARY_SUPPLEMENT: Beta-alanine|DIETARY_SUPPLEMENT: Dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: The Feasibility of Systemic Reaction After Contact Exposure to the Allergenic Food in Children With Known Food Allergy
Status: UNKNOWN
Conditions: Food Allergy|Quality of Life
Interventions: COMBINATION_PRODUCT: application of the allergenic food
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Sleep Privation on Sensorimotor Integration of the Upper Limb During a Manual Endurance Test in Healthy Volunteers-Physiological Study
Status: COMPLETED
Conditions: Sleep Deprivation|Healthy Volunteers|Skeletal Muscle
Interventions: BEHAVIORAL: Normal sleep night|BEHAVIORAL: Sleepless night
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 1 Dose Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Ipilimumab in Chinese Subjects With Select Advanced Solid Tumors
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Chemotherapy Prior to Radiotherapy and Chemotherapy in Patients With HPV Associated Cancer of the Oral Cavity
Status: TERMINATED
Conditions: Oropharyngeal Neoplasms
Interventions: DRUG: chemotherapy|RADIATION: radiotherapy|RADIATION: Reduced dose radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetic Data Collection in Adult Participants to Identify Genetic Variants of Known Importance in Non-alcoholic Steatohepatitis (NASH)
Status: TERMINATED
Conditions: Non-alcoholic Steatohepatitis (NASH)
Interventions: PROCEDURE: No Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Fluzopari Combined With Apatinib for the Neoadjuvant Treatment of Unresectable Ovarian Cancer
Status: NOT_YET_RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: Fluzopari and apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selinexor Plus VRd in High Risk Newly Diagnosed Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Selinexor|DRUG: Bortezomib|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone for the Treatment of Established Postoperative Nausea and Vomiting
Status: TERMINATED
Conditions: Postoperative Nausea and Vomiting|Vomiting
Interventions: DRUG: Placebo|DRUG: Dexamethasone 3 mg|DRUG: Dexamethasone 6 mg|DRUG: Dexamethasone 12 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Assess the Efficacy and Safety of Various Vibrating Capsule Modes
Status: COMPLETED
Conditions: Constipation
Interventions: DEVICE: Vibrating Capsule|DEVICE: Sham capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Phase 2 Study of CI-1040 in Patients With Advanced Nonsmall-Cell Lung, Breast, Colon and Pancreatic Cancer
Status: COMPLETED
Conditions: Colorectal Neoplasms|Breast Neoplasms|Carcinoma, Non-Small-Cell Lung|Pancreatic Neoplasms
Interventions: DRUG: CI-1040
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Auricular Point Acupressure: Examining the Scientific Underpinnings of Pain Relief
Status: TERMINATED
Conditions: Chemotherapy-induced Peripheral Neuropathy (CIPN)
Interventions: BEHAVIORAL: Auricular Point Acupressure|BEHAVIORAL: Control Auricular Point Acupressure-
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SSEP Fluctuations Due to Dexmedetomidine During Posterior Spine Fusion
Status: COMPLETED
Conditions: Spinal Fusion
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Internet-delivered Cognitive Behaviour Therapy for Post-Secondary Students: Preference Trial for Various Course Durations
Status: RECRUITING
Conditions: Depression|Anxiety
Interventions: BEHAVIORAL: Wellbeing Course for Students (Fast Track)|BEHAVIORAL: Wellbeing Course for Students (5 weeks)|BEHAVIORAL: Wellbeing Course (8 weeks)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT