pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Specific Preoperative Dynamic Contrast-enhanced MRI Semi-quantitative Markers Can Correlate With Vascularity in Specific Areas of the Glioblastoma Tissue and Predict Recurrence
Status: COMPLETED
Conditions: Glioblastoma
Interventions: OTHER: Dynamic contrast-enhanced MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Berberine and Cinnamon in Management of Diabetes
Status: COMPLETED
Conditions: Diabetes
Interventions: DIETARY_SUPPLEMENT: Berberine+Cinnamon (TDS)|OTHER: Placebo (TDS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Anthrax Vaccine, GC1109
Status: COMPLETED
Conditions: Anthrax
Interventions: BIOLOGICAL: Low-dose GC1109|BIOLOGICAL: High-dose GC1109|BIOLOGICAL: Low-dose Placebo|BIOLOGICAL: High-dose Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Educational Intervention for Knee Pain
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: BEHAVIORAL: Decision Aid Video|BEHAVIORAL: Motivational Interviewing|BEHAVIORAL: MI plus Decision aid|OTHER: Attention control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Quality of Analgesia After Interscalene Block After Arthroscopic Shoulder Surgery
Status: COMPLETED
Conditions: Injury of Shoulder Region
Interventions: DRUG: Exparel block in arthroscopic shoulder surgery|DRUG: Bupivacaine block in shoulder surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: French National Cohort of Children With Port Wine Stain
Status: COMPLETED
Conditions: Port Wine Stain|Klippel Trenaunay Syndrome|Parkes Weber Syndrome
Interventions: GENETIC: search for polymorphisms of RASA1 gene
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bortezomib, Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant For High-Risk Stage I or II Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Autologous Hematopoietic Stem Cell Transplant Recipient|Loss of Chromosome 17p|Plasma Cell Leukemia|Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: DRUG: bortezomib|DRUG: fludarabine phosphate|OTHER: melphalan|RADIATION: total marrow irradiation|DRUG: tacrolimus|DRUG: sirolimus|PROCEDURE: peripheral blood stem cell transplantation|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tislelizumab in Combination With Pre-operative CRT Versus SOC for Locally Advanced G/GEJ Adenocarcinoma
Status: RECRUITING
Conditions: Gastric Cancer|Gastroesophageal-junction Cancer
Interventions: DRUG: Tislelizumab|DRUG: S-1|DRUG: Oxaliplatin|DRUG: Nab paclitaxel|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aggravated Airway Inflammation: Research on Genomics and Optimal Medical Care (AirGOs-medical)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: DRUG: Placebo Oral Tablet|DRUG: Acetyl Salicylic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Nanocurcumin on Treg Cells and Th17 Cells Responses in Ankylosing Spondylitis Patients
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: DRUG: Nanocurcumin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Mediators and Moderators of Exercise Behavior Change
Status: COMPLETED
Conditions: Validate STRIDE Exercise Intervention in Sedentary Individuals|Increase Positive Attitudes, Perceived Normative Support, Self-efficacy, and Intentions|Increase Self-reported Physical Activity
Interventions: BEHAVIORAL: STRIDE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Exploratory Clinical Study to Evaluation of the Safety and Immunogenicity of Bivalent Vaccine V-01D-351
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19 Pandemic
Interventions: BIOLOGICAL: V-01D-351|BIOLOGICAL: V-01D-351|BIOLOGICAL: CoronaVac|BIOLOGICAL: CoronaVac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: LDL-C Lowering Efficacy and Safety of Rosuvastatin 20 mg/Day to10 mg/Day in Chinese ACS(Acute Coronary Syndrome) Patients
Status: UNKNOWN
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene
Status: COMPLETED
Conditions: Retinitis Pigmentosa|Usher Syndrome Type 2|Deaf Blind|Retinal Disease|Eye Diseases|Eye Diseases, Hereditary|Eye Disorders Congenital|Vision Disorders
Interventions: DRUG: QR-421a|OTHER: Sham-procedure (dose cohort 1&2 only)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Rivaroxaban for Acute Ischemic Stroke or TIA Patients With Atrial Fibrillation
Status: RECRUITING
Conditions: Cerebral Infarction|TIA
Interventions: DRUG: Rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Investigating the Effects of JNJ-54861911 on Amyloid-beta Processing in Cerebrospinal Fluid (CSF) and Plasma in Japanese Participants Asymptomatic at Risk for Alzheimer Dementia
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: JNJ-54861911, 10 mg|DRUG: JNJ-54861911, 50 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety, Efficacy, and Durability of EN3835 in the Treatment and Retreatment of Plantar Fibromatosis
Status: COMPLETED
Conditions: Plantar Fibromatosis
Interventions: BIOLOGICAL: EN3835
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurostimulation Versus Therapy for Problems With Emotions
Status: RECRUITING
Conditions: Emotion Regulation|Mood Disorders|Stress Disorder|Anxiety Disorders|OCD|Impulse Control Disorder|Eating Disorders|Emotional Dysfunction|Emotional Instability|Emotional Distress|Emotional Maladjustment|Emotional Impulsivity|Obsessive-Compulsive Disorder|Emotion Dysregulation|Borderline Personality Disorder
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)|DEVICE: electrical scalp stimulation|BEHAVIORAL: Cognitive Restructuring|BEHAVIORAL: Emotional Awareness Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Octreotide Compared With Loperamide Hydrochloride for Chemotherapy-Related Diarrhea in Patients With Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Diarrhea
Interventions: DRUG: loperamide hydrochloride|DRUG: octreotide acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prospective Trial Using Gastric Stapling Line Reinforcement With Seamguard in Roux-en-Y Gastric Bypass
Status: COMPLETED
Conditions: Gastric Bypass
Interventions: PROCEDURE: Roux-en-Y laparoscopic gastric bypass for morbid obesity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Studying Cells Collected Through Ductal Lavage in Women Undergoing Surgery for Ductal Carcinoma In Situ or Other Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: GENETIC: RNA analysis|GENETIC: polymerase chain reaction|GENETIC: protein expression analysis|GENETIC: reverse transcriptase-polymerase chain reaction|GENETIC: western blotting|OTHER: immunoenzyme technique|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|PROCEDURE: breast duct lavage
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Therapeutic Effects of Forced Aerobic Exercise in Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Forced Aerobic Exercise (FE)|BEHAVIORAL: Voluntary Aerobic Exercise (VE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 2
Status: COMPLETED
Conditions: Behavior, Addictive|Cocaine Abuse|Cocaine Dependence|Heroin Dependence|Opioid Dependence
Interventions: BEHAVIORAL: Contingency management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parent Training to Promote Early Identification and Treatment of Childhood Behavioral Disorders
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity|Attention Deficit and Disruptive Behavior Disorders
Interventions: BEHAVIORAL: Incredible Years Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulpotomy vs Root Canal Treatment for Teeth With Symptomatic Irreversible Pulpitis
Status: RECRUITING
Conditions: Pulpitis - Irreversible
Interventions: PROCEDURE: vital pulp therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Supplementation With Vitamin D on the Acute Bronchitis Prevention During the First Year of Life
Status: COMPLETED
Conditions: Acute Bronchitis|Upper Respiratory Tract Infection|Acute Bronchiolitis
Interventions: DRUG: Vitamin D3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SPL7013 Gel - Male Tolerance Study
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV)
Interventions: DRUG: 3% w/w SPL7013 Gel (VivaGel™)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Peri-implant Mucositis by Application of a Spermidine-based Gel
Status: RECRUITING
Conditions: Peri-implant Mucositis|Mucositis Oral
Interventions: PROCEDURE: Spermidine gel|PROCEDURE: NSMD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Lower Pole Renal Hard Stones ≤2 cm
Status: COMPLETED
Conditions: Renal Stones
Interventions: PROCEDURE: lithotripsy using Flexible ureteroscope|PROCEDURE: extracorporeal shock wave lithotripsy (ESWL)|PROCEDURE: holmium laser lithotripsy using Karl® Storz MIP set
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial in Periodontal Tissue Regeneration Using Fibroblast Growth Factor-2
Status: COMPLETED
Conditions: Periodontitis
Interventions: DRUG: Trafermin (genetical recombinant of human basic Fibroblast Growth Factor)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: RCT to Assess the Impact of Microbiome Status in Infertile IVF Patients at Their First IVF/ICSI Cycle
Status: UNKNOWN
Conditions: Infertility, Female|IVF
Interventions: DIAGNOSTIC_TEST: EMMA/ALICE|DIAGNOSTIC_TEST: EMMA/ALICE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: App-based Recording and Optimization of the Nutritional Status in Patients With Head and Neck Tumors During and After Radio(Chemo)Therapy
Status: RECRUITING
Conditions: Squamous Cell Carcinoma of Head and Neck
Interventions: PROCEDURE: App Usage|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Silicone Earplugs for VLBW Newborns in Intensive Care
Status: COMPLETED
Conditions: Postnatal Growth
Interventions: DEVICE: Silicone Earplugs|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of I.V. CTAP201 and Doxercalciferol (Hectorol) in Subjects With Chronic Kidney Disease (CKD) and Secondary Hyperparathyroidism (SHPT)
Status: COMPLETED
Conditions: Chronic Kidney Disease|Secondary Hyperparathyroidism|Chronic Renal Insufficiency|Chronic Renal Failure
Interventions: DRUG: CTAP201 Injection|DRUG: Doxercalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sodium Glucose Cotransporter-2 Inhibitors and Salt-sensitivity in Type 2 Diabetes
Status: RECRUITING
Conditions: Blood Pressure|Salt; Excess|Diabete Type 2
Interventions: BEHAVIORAL: Hypersodic/Hyposodic diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Shockwave Therapy for Post-RP ED
Status: UNKNOWN
Conditions: Erectile Dysfunction Following Radical Prostatectomy
Interventions: DEVICE: Dornier Aries 2 (with active applicator)|DEVICE: Dornier Aries 2 (with sham applicator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRD-guided Adjuvant Tislelizumab and Chemotherapy in Resected Stage IIA-IIIB NSCLC
Status: RECRUITING
Conditions: NSCLC
Interventions: DRUG: adjuvant tislelizumab and chemotherapy for MRD+ patients|DRUG: adjuvant tislelizumab and chemotherapy for MRD+ patients|DRUG: adjuvant chemotherapy for MRD- patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment of a HYDRAGLYDE® Regimen
Status: COMPLETED
Conditions: Refractive Errors|Myopia|Hypermetropia
Interventions: DEVICE: Lotrafilcon B contact lenses with added wetting agent|DEVICE: Samfilcon A contact lenses|DEVICE: POLYQUAD/ALDOX-preserved contact lens solution with added wetting agent|DEVICE: Hydrogen peroxide-based contact lens solution with added wetting agent|DEVICE: Senofilcon C contact lenses|DEVICE: Senofilcon A contact lenses|DEVICE: Comfilcon A contact lenses|DEVICE: Habitual Multi-Purpose Solution (HMPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Multicentre Study on Rifaximin in Post-operative Endoscopic Crohn's Disease Recurrence Prevention
Status: TERMINATED
Conditions: Crohn Disease
Interventions: DRUG: Rifaximin delayed release tablets|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Interleukin-1 Receptor Antagonist (IL-1RA) (ANAKINRA) IN SEVERE SYSTEMIC-ONSET JUVENILE IDIOPATHIC ARTHRITIS
Status: COMPLETED
Conditions: Systemic-Onset Juvenile Idiopathic Arthritis
Interventions: DRUG: Anakinra|BIOLOGICAL: Pneumo23
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Fibrocytes in Rheumatoid Arthritis, Asthma and Interstitial Lung-disease.
Status: COMPLETED
Conditions: Interstitial Lung Diseases|Rheumatoid Arthritis|Asthma
Interventions: OTHER: Fibrocyte measurement and lung function test.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of AT-527 in Healthy and HCV-Infected Subjects
Status: COMPLETED
Conditions: Chronic Hepatitis C|Hepatitis C|Hepatitis C, Chronic
Interventions: DRUG: AT-527|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: IBI110 Combined With Sintilimab in Second-line Advanced or Metastatic Esophageal Squamous Cell Carcinoma(ESCC)
Status: NOT_YET_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma (ESCC)|PD-1 Inhibitors
Interventions: DRUG: IBI110+Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Exploring the Use of Hyperbaric Oxygen in Autologous Peripheral Blood Stem Cell Transplantation
Status: UNKNOWN
Conditions: Multiple Myeloma|Hodgkin's Disease|Non-Hodgkin's Lymphoma
Interventions: DEVICE: Administration of hyperbaric oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Nelarabine (506U78)in Japanese Patients With Leukemia or Lymphoma
Status: COMPLETED
Conditions: Leukaemia, Lymphoblastic, Acute and Lymphoma, Lymphoblastic
Interventions: DRUG: Nelarabine injection 400mg/m2|DRUG: Nelarabine injection 650mg/m2|DRUG: Nelarabine injection 1000mg/m2|DRUG: Nelarabine injection 1500mg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)
Status: RECRUITING
Conditions: Breast Cancer, Early Breast Cancer
Interventions: DRUG: Camizestrant|DRUG: Tamoxifen|DRUG: Anastrozole|DRUG: Letrozole|DRUG: Exemestane|DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating 13-valent Pneumococcal Conjugate Vaccine In Healthy Infants
Status: COMPLETED
Conditions: Vaccines, Pneumococcal
Interventions: BIOLOGICAL: 13-valent Pneumococcal Conjugate Vaccine|BIOLOGICAL: 7vPnC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Intravenous Plasma Treatment for Parkinson's Disease
Status: COMPLETED
Conditions: Idiopathic Parkinson Disease
Interventions: BIOLOGICAL: [21CFR640.30] Plasma from 18 - 25 year old volunteer donors|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Perfusion CT Derived Parameters as Early Acute Pancreatitis Severity Biomarker Compared to Clinico Biological Score
Status: COMPLETED
Conditions: Acute Pancreatitis
Interventions: RADIATION: Perfusion computed tomography.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparing Epidural Versus General Anesthesia for LESS Cholecystectomies
Status: UNKNOWN
Conditions: Cholelithiasis
Interventions: PROCEDURE: General Anesthesia|PROCEDURE: Epidural Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sertraline Combined With Fluvoxamine in the Treatment of Refractory Obsessive-compulsive Disorder
Status: RECRUITING
Conditions: OCD
Interventions: DRUG: sertraline fluvoxamine|DRUG: sertraline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radioimmunotherapy With 90Y-ibritumomab Tiuxetan as Part of a Dose Reduced Conditioning Regimen for Allogeneic Hematopoietic Cell Transplantation for the Treatment of Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin Lymphoma
Interventions: DRUG: Radioimmunotherapy|PROCEDURE: allogeneic hematopoietic cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Crenezumab Versus Placebo to Evaluate the Efficacy and Safety in Participants With Prodromal to Mild Alzheimer's Disease (AD)
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: Crenezumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Zonisamide and Reinforcement for Reducing Alcohol Use (ZARRA) Study
Status: RECRUITING
Conditions: Alcohol Use Disorder (AUD)
Interventions: DRUG: Zonisamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis
Status: WITHDRAWN
Conditions: Trachoma|Lymphatic Filariasis
Interventions: DRUG: azithromycin|DRUG: ivermectin|DRUG: albendazole|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Application Research on Endoscopic Pseudocapsule-Based Resection for Pituitary Adenomas
Status: RECRUITING
Conditions: Pituitary Adenoma
Interventions: PROCEDURE: Excision of pituitary tumor outside pseudocapsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lurasidone Vs Olanzapine on Neurotrophic Biomarkers and Cardiometabolic Parameters in Unmedicated Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Olanzapine|DRUG: Lurasidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interstitial Photodynamic Therapy in Treating Patients With Recurrent Head and Neck Cancer
Status: TERMINATED
Conditions: Recurrent Laryngeal Squamous Cell Carcinoma|Recurrent Laryngeal Verrucous Carcinoma|Recurrent Lip and Oral Cavity Squamous Cell Carcinoma|Recurrent Metastatic Squamous Cell Carcinoma in the Neck With Occult Primary|Recurrent Oral Cavity Verrucous Carcinoma|Recurrent Oropharyngeal Squamous Cell Carcinoma|Tongue Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Photodynamic Therapy|DRUG: Porfimer Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metacognitive Therapy for Obsessive-Compulsive Disorder
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: BEHAVIORAL: Metacognitive Therapy|OTHER: General mental health promotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Epidural Analgesia and Postoperative Respiratory Functions (EPAPRES)
Status: COMPLETED
Conditions: Respiration Disorders
Interventions: PROCEDURE: Thoracic epidural analgesia|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cognitive Behavioral Therapy in Helping Patients With Acute Myeloid Leukemia or Lymphoma With Cancer-Related Fatigue
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Cancer Fatigue|Lymphoma|Secondary Acute Myeloid Leukemia
Interventions: BEHAVIORAL: Cognitive Behavior Therapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Safety and Immune Response of Quadrivalent Seasonal Influenza Vaccine (Fluarix Tetra) in Participants Aged 65 Years and Older in India
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: Fluarix Tetra Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Functional Outcomes Between Transanal and Laparoscopic vs Open Ileal Pouch-Anal Anastomosis
Status: RECRUITING
Conditions: Ulcerative Colitis|Inflammatory Bowel Diseases|Ileal Pouch
Interventions: PROCEDURE: ta-IPAA|PROCEDURE: tabd-IPAA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Cadonilimab（AK104）Combined With Standard Treatment for Function Preservation in Urinary System Tumors
Status: NOT_YET_RECRUITING
Conditions: Urinary System Tumor
Interventions: DRUG: Cadonilimab plus chemotherapy|DRUG: Cadonilimab plus TKI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Dutogliptin in Patients With Type 2 Diabetes Mellitus (T2DM) on Background Therapy With Glimepiride With or Without Metformin
Status: TERMINATED
Conditions: Diabetes Mellitus, Type II
Interventions: DRUG: Dutogliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Patients on AVAMYS ® Versus NASONEX (A Trade Mark of Schering Corporation) and FLIXONASE ® on Key Health Outcome Measures
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial
Interventions: DRUG: Fluticasone furoate|DRUG: mometasone furoate|DRUG: fluticasone propionate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety of Bronchial Allergen Challenge and Predictors for Positive Reaction.
Status: COMPLETED
Conditions: House Dust Mite Allergy|Bronchial Hyperresponsiveness
Interventions: BIOLOGICAL: house dust mite and alternaria allergen bronchial challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study Evaluating MyoRegulator® Treatment in Post-Stroke Upper Limb Spasticity
Status: TERMINATED
Conditions: Muscle Spasticity|Stroke
Interventions: DEVICE: MyoRegulator® device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aripiprazole Effects on Alcohol Drinking and Craving
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: Aripiprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effects of a Self-help Mobile Phone Application on Worry and Overthinking in Young Adults Aged Between 16 and 24.
Status: COMPLETED
Conditions: Rumination|Worry|Repetitive Negative Thinking
Interventions: DEVICE: digital CBT self-help including specific intervention elements to target worry and rumination.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair
Status: RECRUITING
Conditions: Mitral Valve Insufficiency
Interventions: DEVICE: NeoChord DS1000|DEVICE: Surgical Mitral Valve Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dexamethasone on the Action of Sugammadex
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: DRUG: Dexamethasone|DRUG: Normal Saline|DRUG: sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Study of ADH-1 Given Intravenously to Patients With Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: ADH -1 (Exherin™)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of KW-6002 (Istradefylline) in Parkinson's Disease in Patients With Motor Response Complications on Levodopa
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Istradefylline|DRUG: Istradefylline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GSK3174998 Alone and With Pembrolizumab in Participants With Advanced Solid Tumors (ENGAGE-1)
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: GSK3174998|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Bystander Fatigue and CPR Quality When Using Two Different CPR Ratios.
Status: COMPLETED
Conditions: Cardiac Arrest
Interventions: PROCEDURE: bystander CPR using 30:2 ratio vs 15:2 ratio
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: ERr 731® Formulation Evaluation
Status: COMPLETED
Conditions: Menopause
Interventions: DIETARY_SUPPLEMENT: ERr 731 - Micro-coated|DIETARY_SUPPLEMENT: ERr 731 - Enteric coated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Drug to Drug Interaction Study of Sotagliflozin With Hydrochlorothiazide
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sotagliflozin (SAR439954)|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Two Diets With Different Content of Protein on Weight Loss in Adults With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome X|Weight Loss
Interventions: OTHER: High protein diet|OTHER: Low protein diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Anticoagulation After Endoscopic Therapy in Cirrhotic Patients With Portal Vein Thrombosis
Status: UNKNOWN
Conditions: Portal Vein Thrombosis|Liver Cirrhosis
Interventions: DRUG: Nadroparin Calcium and Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Autologous Stem Cell Transplantation for Patients With Ischemic Stroke
Status: COMPLETED
Conditions: Infarction, Middle Cerebral Artery
Interventions: OTHER: Autologous cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: fMRI in Postural Tachycardia Syndrome
Status: RECRUITING
Conditions: Postural Tachycardia Syndrome
Interventions: OTHER: Lower Body Negative Pressure|OTHER: Sham Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Remote Ischemic Preconditioning During Lower Limb Revascularization
Status: COMPLETED
Conditions: Ischemic Preconditioning|Acute Kidney Injury|Limb Ischemia
Interventions: PROCEDURE: RIPC|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study the Effects of Different Doses of UK-369,003 in Men With Lower Urinary Tract Symptoms.
Status: COMPLETED
Conditions: Prostatic Hyperplasia
Interventions: DRUG: Tamsulosin|DRUG: UK-369,003
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combined 25-gauge Vitrectomy and Cataract Surgery With Toric Intraocular Lens With Idiopathic Epiretinal Membrane.
Status: UNKNOWN
Conditions: Cataract|Epiretinal Membrane|Corneal Astigmatism
Interventions: DEVICE: Vitrectomy with cataract surgery and toric IOL|DEVICE: Vitrectomy with cataract surgery and common IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NEM® + BIOCURC® Versus Placebo in Exercised-induced Joint Pain, Stiffness, & Cartilage Turnover in Healthy Men & Women
Status: COMPLETED
Conditions: Exercise-induced Joint Pain|Exercise-induced Joint Stiffness|Exercise-induced Joint Cartilage Turnover
Interventions: DIETARY_SUPPLEMENT: NEM® + BIOCURC®|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Comparison of Stroke Volume Variation for Prediction of Fluid Responsiveness
Status: NOT_YET_RECRUITING
Conditions: Stroke Volume Variation|SVV-FloTrac|Thoracic Electrical Bioimpedance|Fluid Responsiveness
Interventions: DEVICE: Flotrac Group|DEVICE: BioZ Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Preservative-free Fixed-dose Combination of Tafluprost 0.0015% / Timolol 0.5% in Patients With Open-angle Glaucoma or Ocular Hypertension: Clinical Effectiveness, Tolerability and Safety in a Real World Setting
Status: COMPLETED
Conditions: Ocular Surface Disease|Primary Open Angle Glaucoma
Interventions: DRUG: Tafluprost, timolol maleate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Subcutaneous Injection of Low-dose rhGM-CSF +/- WLL in PAP.
Status: UNKNOWN
Conditions: Pulmonary Alveolar Proteinosis
Interventions: DRUG: rhGM-CSF|PROCEDURE: Whole Lung Lavage(WLL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Design, Implementation and Evaluation of an Intervention Within Video Game for Mental Health Literacy in Adolescents and Young Adults
Status: NOT_YET_RECRUITING
Conditions: Mental Health Literacy
Interventions: BEHAVIORAL: Mental health literacy intervention|BEHAVIORAL: Non mental health intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prevalence of Trephined Syndrome After Decompressive Craniectomy
Status: TERMINATED
Conditions: Trephined Syndrome|Sinking Skin Flap Syndrome|Traumatic Brain Injury|Stroke|Post Operative Hemorrhage|Post-Op Complication|Post-Op Infection
Interventions: PROCEDURE: Decompressive craniectomy|PROCEDURE: Cranioplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Investigational Drug Study in Patients With Type 2 Diabetes Mellitus (MK0431-023)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Comparator: sitagliptin 100 mg|DRUG: Comparator: sitagliptin 200 mg|DRUG: Comparator: placebo|DRUG: Comparator: pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CSD201001: Study to Assess Elements of Abuse Liability for Three Nicotine Pouches
Status: COMPLETED
Conditions: Smoking|Tobacco Use|Tobacco Smoking
Interventions: OTHER: Product A|OTHER: Product B|OTHER: Product C|OTHER: Product D|OTHER: Product N
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Remimazolam and Dexmedetomidine on the Incidence of Hypotension During Spinal Anesthesia
Status: NOT_YET_RECRUITING
Conditions: Remimazolam|Spinal Anesthesia
Interventions: DRUG: Remimazolam|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Greater Trochanteric Pain Syndrome: Efficacy of Ultrasound Guided Platelet-rich Plasma vs Needle Tenotomy.
Status: COMPLETED
Conditions: Tendinopathy
Interventions: DRUG: platelet rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Pranic Healing on Cardiorespiratory Indices and Pain During Venipuncture in Children
Status: NOT_YET_RECRUITING
Conditions: Pain, Acute|Therapeutic Touch
Interventions: BEHAVIORAL: Pranic Healing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dry Eye Assessment and Management: Feasibility Study
Status: COMPLETED
Conditions: Dry Eye Syndromes|Keratoconjunctivitis Sicca
Interventions: DRUG: Omega-3 EFA Supplement|DRUG: Olive Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Administration of High Levels of Protein to Critically Ill Patients.
Status: ACTIVE_NOT_RECRUITING
Conditions: Intensive Care Unit Acquired Weakness
Interventions: OTHER: Protein dose 1.5 g/kg/day|OTHER: Protein dose 1.0 g/kg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of YKP10811 in Subjects With Irritable Bowel Syndrome With Constipation
Status: COMPLETED
Conditions: Irritable Bowel Syndrome|Constipation
Interventions: DRUG: YKP10811 5mg|DRUG: YKP10811 20mg|DRUG: YKP10811 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Research of ROBO1 Specific BiCAR-NK Cells on Patients With Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: BiCAR-NK cells (ROBO1 CAR-NK cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib Plus Doxorubicin Versus Sorafenib Alone for the Treatment of Advanced Hepatocellular Carcinoma: a Randomized Phase II Trial
Status: UNKNOWN
Conditions: Liver Carcinoma
Interventions: DRUG: Doxorubicin|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Express Plus Range
Status: RECRUITING
Conditions: Phenylketonurias|PKU|Homocystinuria|Maple Syrup Urine Disease|Hereditary Tyrosinemia|Glutaric Acidemia I
Interventions: DIETARY_SUPPLEMENT: PKU express plus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Alcohol History on Effects of Nitrous Oxide - 9
Status: COMPLETED
Conditions: Alcohol-Related Disorders|Opioid-Related Disorders|Substance-Related Disorders
Interventions: DRUG: 0% N2O and 10% N2O|DRUG: 0% N2O and 20% N2O|DRUG: 0% N2O and 30% N2O|DRUG: 0% N2O and 40% N2O
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Dissecting the IMpact of 11-OXygenated and Classic Androgens on Skeletal Muscle Insulin Sensitivity (DIMOXIS)
Status: RECRUITING
Conditions: Polycystic Ovary Syndrome|Insulin Resistance|Androgen; Hypersecretion|Endocrine System Diseases
Interventions: DIETARY_SUPPLEMENT: Dehydroepiandrosterone (DHEA)|DIETARY_SUPPLEMENT: 11-ketoandrostenedione (11KA4)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: BMS-562247 in Subjects Undergoing Elective Total Knee Replacement Surgery
Status: COMPLETED
Conditions: Venous Thrombosis|Pulmonary Embolism
Interventions: DRUG: Apixaban|DRUG: Enoxaparin|DRUG: Warfarin|DRUG: Enoxaparin Placebo|DRUG: Apixaban Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Fractional Laser Assisted Delivery of Anesthetics IIIb
Status: COMPLETED
Conditions: Local Anesthesia of the Skin
Interventions: DRUG: AHES 5 minutes|DRUG: AHES 15 minutes|DRUG: AHES 25 minutes|DRUG: LTC 5 minutes|DRUG: LTC 15 minutes|DRUG: LTC 25 minutes|DEVICE: fractional CO2 laser, 50 mJ, 5% density
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Dupilumab in Participants With Moderate to Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Placebo|DRUG: Dupilumab|OTHER: Background treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: mHealth App Intervention to Improve Medication Adherence
Status: COMPLETED
Conditions: Medication Adherence|Adherence, Treatment
Interventions: BEHAVIORAL: mHealth using"WhatsApp" multifaceted educational and reminder module intervention to improve adherence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Neonatal Cardio-Pulmonary Outcome Measure
Status: COMPLETED
Conditions: Congenital Heart Defect|Respiratory Distress Syndrome in Premature Infant
Interventions: OTHER: Neonatal cardio-pulmonary outcome measure used to assess cardio-pulmonary status
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Connecting Youth and Young Adults to Optimize ART Adherence: YouTHrive Efficacy Trial
Status: COMPLETED
Conditions: HIV Infections
Interventions: BEHAVIORAL: YouTHrive|BEHAVIORAL: Information-only Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic (PD) Study of Intranodal Adenovirus-CD154 (Ad-ISF35) in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: BIOLOGICAL: Intranodal injection of Ad-ISF35
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of FKB238 and Avastin in Patients With Advanced/Recurrent Non-squamous Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: FKB238 (bevacizumab)|DRUG: Avastin (bevacizumab)|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perimenstrual Acne With Clindamycin Phosphate and Benzoyl Peroxide
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: lidamycin phosphate and benzoyl peroxide 1.2%/3.75% combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile Application-delivered Resistance Program for Children and Adolescents With Type 1 Diabetes (Diactive-1)
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 1 Diabetes
Interventions: DEVICE: Diactive-1 application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SAD/MAD Study in Healthy Subjects and Adults With UC to Evaluate Safety, Tolerability, PK, PD of AMT-101
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: AMT-101|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study to Evaluate the Efficacy and Safety of Tralokinumab in Adults and Adolescents With Uncontrolled Asthma
Status: COMPLETED
Conditions: Uncontrolled Asthma
Interventions: BIOLOGICAL: Tralokinumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Linperlisib in Relapsed/Refractory Large Granular T Lymphocytic Leukemia
Status: RECRUITING
Conditions: Relapsed/Refractory Large Granular T Lymphocytic Leukemia
Interventions: DRUG: Linperlisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT