pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Short-Course Radiotherapy Followed by Neoadjuvant Chemotherapy and Camrelizumab in Locally Advanced Rectal Cancer (UNION)
Status: ACTIVE_NOT_RECRUITING
Conditions: Rectal Cancer
Interventions: COMBINATION_PRODUCT: Short course radiotherapy sequential camrelizumab and chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beta-carotene Absorption and Bioconversion to Vitamin A From Biofortified Cassava Gari
Status: COMPLETED
Conditions: Vitamin A Deficiency
Interventions: OTHER: Biofortified cassava gari|OTHER: White cassava gari|OTHER: White cassava gari + red palm oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Oscillating-Rotating Electric Toothbrushes on Plaque and Gingival Health
Status: COMPLETED
Conditions: Gingivitis|Plaque
Interventions: DEVICE: Oscillating-rotating electric toothbrush|DEVICE: Side-to-side electric toothbrush|DEVICE: Manual toothbrush
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase I Clinical Study of Intratumoral Injection Oncolytic Vaccinia Virus GC001 in Patient With Advanced Solid Tumors
Status: RECRUITING
Conditions: Sarcoma|Cervical Cancer|Colon Cancer|Lung Cancer|Ovarian Cancer|Pancreatic Cancer|Hepatocellular Carcinoma|Breast Cancer|Gastric Cancer
Interventions: BIOLOGICAL: A Phase I Clinical Study of Intratumoral Injection Oncolytic Vaccinia Virus GC001 in Patients With Advanced Solid Tumors
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial Comparing SpineJet® Hydrodiscectomy to Open Lumbar Microdiscectomy for Treatment of Lumbar Radiculopathy Due to Disc Herniation
Status: COMPLETED
Conditions: Disc Herniation With Radiculopathy
Interventions: PROCEDURE: Hydrodiscectomy with Spinejet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection of Upper Gastrointestinal (GI) Bleeding With a Novel Bleeding Sensor Capsule [DING]
Status: COMPLETED
Conditions: Upper GI Bleeding
Interventions: DIAGNOSTIC_TEST: HemoPill acute
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study to Assess the Long-term Safety and Tolerability of TMC114/Rtv in HIV-1 Infected Participants After Rolling-over From Other TMC114 Trials
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: TMC114|DRUG: rtv
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-shivering Effect of Ondansetron
Status: UNKNOWN
Conditions: Shivering|Ondansetron
Interventions: DRUG: Normal saline|DRUG: Ondansetron 4 MG|DRUG: Ondansetron 8mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Trauma-Informed Intervention for Positive Youth Development and Teacher Wellness in Rural Montana Year 2
Status: COMPLETED
Conditions: Trauma and Stressor Related Disorders
Interventions: BEHAVIORAL: Trauma-Informed Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Feasibility and Efficacy of Dietary Interventions for Older Adults With Subjective Cognitive Decline
Status: WITHDRAWN
Conditions: Alzheimer Disease|Cognitive Impairment
Interventions: DIETARY_SUPPLEMENT: MAD|DIETARY_SUPPLEMENT: MIND
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Serum Tryptase Concentration During General Anaesthesia With Rocuronium
Status: COMPLETED
Conditions: Hypersensitivity Reaction
Interventions: DRUG: Rocuronium|DRUG: general volatile anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rilotumumab in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Rilotumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial Study of Hip System in Primary Total Hip Arthroplasty in China
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Congenital Hip Dysplasia|Avascular Necrosis
Interventions: DEVICE: Total Hip System made in China (SUN, CoCr, Duraloc, Marathon)|DEVICE: Total Hip System made outside of China (Summit, CoCr, Duraloc, Marathon)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intra-articular Injection of MSC-derived Exosomes in Knee Osteoarthritis (ExoOA-1)
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: BIOLOGICAL: Exosomes (sEVs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Repair Versus Branched Endograft Repair for Treatment of Residual Chronic Aortic Arch Dissection During Follow-up After Open Type A Acute Ascending Aorta Replacement: Results From an International Multicenter Study.
Status: RECRUITING
Conditions: Peri-operative Mortality
Interventions: PROCEDURE: Frozen Elephant Trunk Technique
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Water-aided Colonoscopy vs Air Insufflation Colonoscopy in Colorectal Cancer Screening
Status: COMPLETED
Conditions: Colorectal Cancer|Colorectal Adenomas|Colorectal Polyps|Pain
Interventions: OTHER: Air insufflation method.|OTHER: Water Immersion method.|OTHER: Water Exchange method.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Clinical Trial to Evaluate the Safety and Pharmacokinetic Characteristics of CKD-333 or Co-administration of CKD-333 and D085 in Healthy Volunteers
Status: UNKNOWN
Conditions: Cardiovascular Diseases
Interventions: DRUG: CKD-330 1 Tab. and D085 1 Tab.|DRUG: CKD-333 1 Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Pharmacokinetics of Bromine Hexane Hydrochloride Tablets in Healthy Adults
Status: NOT_YET_RECRUITING
Conditions: Pharmacokinetics
Interventions: DRUG: Bromhexine Hydrochloride Tablet|DRUG: Bromhexine Hydrochloride Tablet|DRUG: Bromhexine Hydrochloride Tablet|DRUG: Bromhexine Hydrochloride Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety, Tolerability and PK of Different Formulations of Orally Administered Solabegron in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Subjects, Overactive Bladder
Interventions: DRUG: Formulation 1 solabegron|DRUG: Formulation 2 solabegron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Patients With and Without Foreign Body Aspiration After Bronchoscopy.
Status: UNKNOWN
Conditions: Foreign Body Aspiration, Blood Gas, Bronchoscopy
Interventions: DEVICE: Rigit bronchoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Norepinephrine Versus Ephedrine in Treatment of Hypotension During Spinal Anesthesia for Caesarean Section
Status: COMPLETED
Conditions: Hypotension|Vasopressors|Cesarean Section Complications|Anesthesia Complication
Interventions: DRUG: Norepinephrine|DRUG: Ephedrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Technical Capabilities of the "SMART ANGEL Intra-hospital" System 's Connected Medical Device (CMD)
Status: UNKNOWN
Conditions: Medical Device
Interventions: DEVICE: Connected Medical Device|DEVICE: Traditional transmission system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effects of a Contextual Decision-making Materials on Junior Nurses in Traumatic Learning Performance
Status: RECRUITING
Conditions: Abdominal Injury|Pelvic Injury
Interventions: DEVICE: Interactive Educational Material for Decision-Making|DEVICE: Interactive Educational Material
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Experimental Intervention on the Influence of Six Weeks' Content Knowledge on Students' Written Test Achievement
Status: COMPLETED
Conditions: Educational Problems|Student Burnout
Interventions: DIAGNOSTIC_TEST: Teaching intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Diet Intervention in Food Sensitive Patients With IgA Nephropathy
Status: UNKNOWN
Conditions: IGA Nephropathy
Interventions: DIETARY_SUPPLEMENT: Tailored diet|DIETARY_SUPPLEMENT: Low antigen content diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tackling Two of the Most Important Unresolved Tasks in Reading Intervention
Status: NOT_YET_RECRUITING
Conditions: Dyslexia, Developmental
Interventions: BEHAVIORAL: Phonics plus morphology|BEHAVIORAL: Phonics plus set-for-variability
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: IMM2520, a PD-L1 and CD47 Bispecific Antibody in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Non-small Cell Lung Cancer|Small Cell Lung Cancer|Breast Cancer|Squamous Cell Cancer of Head and Neck|Colorectal Cancer
Interventions: DRUG: IMM2520
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Stroke and Systemic Embolic Events in Patients With Atrial Fibrillation
Status: COMPLETED
Conditions: Nonvalvular Atrial Fibrillation
Interventions: DRUG: AZD0837|DRUG: Vitamin-K antagonist at INR 2-3|DRUG: AZD0837
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I Study of GNKG168 in Acute Lymphoblastic Leukemia and Acute Myelogenous Leukemia
Status: TERMINATED
Conditions: Relapsed Acute Lymphoblastic Leukemia|Relapsed Acute Myelogenous Leukemia
Interventions: DRUG: GNKG168
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Longitudinal Assessment of Clinical Course and BIOmarkers in Severe Chronic AIRway Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Asthma|COPD
Interventions: DRUG: prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Efavaleukin Alfa in Participants With Moderately to Severely Active Ulcerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: Efavaleukin alfa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ultra-Early, Minimally inVAsive intraCerebral Haemorrhage evacUATion Versus Standard trEatment
Status: RECRUITING
Conditions: Intra Cerebral Hemorrhage|Stroke
Interventions: PROCEDURE: Minimally invasive hematoma evacuation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin Type A for Neuropathic Pain in Patients With Diabetic Peripheral Polyneuropathy
Status: TERMINATED
Conditions: Neuralgia
Interventions: BIOLOGICAL: Botulinum toxin type A|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Posterior Spinal Fusion With Pedicle Screws vs. Anterior Vertebral Body Tethering in Adolescent Idiopathic Scoliosis
Status: NOT_YET_RECRUITING
Conditions: Adolescent Idiopathic Scoliosis
Interventions: DEVICE: Posterior spinal fusion with pedicle screws|DEVICE: Anterior vertebral body tethering
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sofosbuvir With Ribavirin or Simeprevir With HCV GT4 Egyptian Patients
Status: COMPLETED
Conditions: Chronic Hepatitis C Virus Infection
Interventions: DRUG: Sofosbuvir + Simeprevir + Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB061 in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIIB061|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Analysis of Posaconazole in Lung Transplant Recipients (MK-5592-105)
Status: TERMINATED
Conditions: Fungal Infection
Interventions: DRUG: Posaconazole|DRUG: Calogen®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Neuroprotective Effect of PROCRIT (Epoetin Alfa) Versus Placebo in Cancer Patients Who Develop Chemotherapy-induced Peripheral Neuropathy
Status: TERMINATED
Conditions: Peripheral Neuropathy, Chemotherapy-induced
Interventions: DRUG: PROCRIT 40,000 IU QW|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Venlafaxine PK Following Bariatric Surgery
Status: COMPLETED
Conditions: Roux en Y Gastric Bypass|Sleeve Gastrectomy
Interventions: DRUG: Venlafaxine IR and Venlafaxine XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Effects of Peanut Intake on Cognitive Functions
Status: ACTIVE_NOT_RECRUITING
Conditions: Cognition|Inflammation
Interventions: DIETARY_SUPPLEMENT: Peanuts|OTHER: Habitual Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Drug-drug Interaction Study With Risdiplam Multiple Dose and Midazolam in Healthy Participants
Status: COMPLETED
Conditions: Spinal Muscular Atrophy
Interventions: DRUG: Risdiplam|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hepatic Arterial Infusion of Nab-Paclitaxel in Patients With Metastatic Melanoma in the Liver
Status: COMPLETED
Conditions: Melanoma|Liver Metastasis
Interventions: DRUG: Nab-Paclitaxel (Abraxane)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Alleviation of Forearm Fractures
Status: COMPLETED
Conditions: Pain|Forearm Fracture
Interventions: DRUG: ketamine in hematoma block|DRUG: ketamine in local intravenous anesthesia|DRUG: Lidocaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Psychophysical Analysis of Adolescent Patients With Obesity and Efficacy of the Respiratory Approach (PSICOFISADOLOB).
Status: RECRUITING
Conditions: Obesity, Childhood
Interventions: OTHER: Standard metabolic integrated rehabilitation protocol - duration 3 weeks|OTHER: Standard metabolic integrated rehabilitation protocol + respiratory exercises - duration 3 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Intravenous Streptokinase in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Disease|Heart Diseases|Myocardial Infarction|Myocardial Ischemia
Interventions: DRUG: streptokinase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of Nivolumab in Combination With Ipilimumab in Participants With Advanced Hepatocellular Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab|DRUG: Sorafenib|DRUG: lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Ranging Study of Ferroquine With Artesunate in African Adults and Children With Uncomplicated Plasmodium Falciparum Malaria
Status: TERMINATED
Conditions: Plasmodium Falciparum Infection
Interventions: DRUG: Ferroquine (SSR97193)|DRUG: Placebo|DRUG: artesunate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Guiding Dose Increases in Patients Incompletely Responsive to Usual Doses of Atomoxetine
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Atomoxetine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Trial to Determine the Therapeutic Benefit of an OTC Cream on Dry, Itchy Skin of Adults and Children With Eczema
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DEVICE: EpiCeram Skin Barrier Emulsion|DRUG: Experimental Product 1% Colloidal Oatmeal Balm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Home Parenteral Nutrition for Malnourished Unresectable Stage IV Gastric Cancer
Status: COMPLETED
Conditions: Metastatic Gastric Cancer
Interventions: OTHER: Oliclinomel N4 Per bag 1.5 L|DRUG: Oxaliplatin|DRUG: 5Fluorouracil|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of SR58611A in Patients With Major Depressive Disorder (SIRIUS)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: amibegron (SR58611A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Opioid Sparing Anesthesia in Lumbar Spine Surgery
Status: RECRUITING
Conditions: Pain, Postoperative|Pain, Acute|Pain, Chronic|Pain, Nociceptive|Ketamine|Lidocaine|Dexmedetomidine|Analgesia|Analgesics|Lumbar Spine Surgery
Interventions: DRUG: dexmedetomidine-ketamine-lidocaine|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 1/2 Study Evaluating Safety and Potential Efficacy of Allocetra-OTS Via Pressurized Intra-Peritoneal Aerosol Chemotherapy as Add-on to Standard of Care Chemotherapy for Treatment of Peritoneal Metastasis
Status: TERMINATED
Conditions: Peritoneal Metastases
Interventions: DRUG: Allocetra-OTS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Switching From Regimens Consisting of Boosted Atazanavir or Darunavir Plus Either Emtricitabine/Tenofovir or Abacavir/Lamivudine to Bictegravir/Emtricitabine/Tenofovir Alafenamide in Virologically Suppressed HIV-1 Infected Adults
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: RTV|DRUG: ATV|DRUG: DRV|DRUG: COBI|DRUG: ATV/co|DRUG: DRV/co|DRUG: FTC/TDF|DRUG: ABC/3TC|DRUG: B/F/TAF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Population Pharmacokinetic Study of the Effect of Polymorphisms in the ABCB1 and CES1 Genes on the Pharmacokinetics of Dabigatran
Status: NOT_YET_RECRUITING
Conditions: Combined Analysis of Polymorphisms and Dabigatran Pharmacokinetic Parameters
Interventions: DRUG: Dabigatran Etexilate 150mg
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intracorporeal or Extracorporeal Anastomosis After Laparoscopic Right Colectomy.
Status: UNKNOWN
Conditions: Colon Cancer|Anastomosis
Interventions: PROCEDURE: Laparoscopic right colectomy with intracorporeal ileocolic anastomosis (IIA)|PROCEDURE: Laparoscopic right colectomy with extracorporeal ileocolic anastomosis (EIA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Concentrated Growth Factors on Healing of Apicomarginal Defects: a Prospective Study
Status: RECRUITING
Conditions: Concentrated Growth Factor|Bone Substitute
Interventions: OTHER: concentrated growth factor|OTHER: bone substitute|COMBINATION_PRODUCT: concentrated growth factor + bone substitute
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: F18 Fluciclovine PET/CT in Assessing Tumor Volume and Radiation Therapy Response in Patients With Glioblastoma Undergoing Surgery
Status: COMPLETED
Conditions: Glioblastoma
Interventions: PROCEDURE: Computed Tomography|OTHER: Fluciclovine F18|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Double-blind Comparative Study of SYR-472
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: SYR-472|DRUG: Alogliptin 25 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study Comparing 2 Doses of CP-690,550 vs. Placebo for Treatment of Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: CP-690,550|DRUG: CP-690,550|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-Blind Study Evaluating Duvelisib in Subjects With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Methotrexate Alone
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: IPI-145|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Clinical Trial for Inactivated Quadrivalent Influenza Vaccine (Split Virion) in Healthy Adults in China
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: inactivated quadrivalent influenza vaccine (split virion)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Lenvatinib Plus PD-1 Antibody for Intermediate-stage HCC Beyond Up-to-seven Criteria
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Lenvatinib|DRUG: PD-1 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Trial for Pharmacokinetic Characteristics of Factive 200mg Intravenous Formulation (Gemifloxacin 200mg) With Factive 320mg Tablet Formulation (Gemifloxacin 320mg)
Status: COMPLETED
Conditions: Infectious Diseases
Interventions: DRUG: Factive® Tab / Factive IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Automation Oxygen Flow Titration in Spontaneously Breathing Infants
Status: TERMINATED
Conditions: Bronchiolitis
Interventions: DEVICE: FreeO2 (modèle FO2-220-00) automatic oxygen flow titration|DEVICE: FreeO2 (modèle FO2-220-00) manual oxygen flow titration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating and Comparing the Safety and Efficiency of ASC09/Ritonavir and Lopinavir/Ritonavir for Novel Coronavirus Infection
Status: TERMINATED
Conditions: 2019-nCoV
Interventions: DRUG: ASC09/ritonavir group|DRUG: lopinavir/ritonavir group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Oral and Nasal Enteral Nutrition Feeding Quantity in Stroke Patients
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: DEVICE: Intermittent Oro-esophageal Tube Feeding|DEVICE: Nasogastric Tube|BEHAVIORAL: comprehensive rehabilitation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Music & MEmory: A Pragmatic TRial for Nursing Home Residents With ALzheimer's Disease (METRIcAL)_part2
Status: ENROLLING_BY_INVITATION
Conditions: Dementia
Interventions: BEHAVIORAL: Music & Memory
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of NKTR-358 (LY3471851) in Participants With Systemic Lupus Erythematosus (SLE)
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: LY3471851|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Supporting Trans Affirmation, Relationships, and Sex, Phase 3
Status: RECRUITING
Conditions: HIV|Violence, Gender-Based|Violence, Domestic|Risk Reduction Behavior
Interventions: BEHAVIORAL: Program STARS (Supporting Trans Affirmation, relationships, and Sex)|BEHAVIORAL: Relaxation and Stress Reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Intraoperative Dynamic Compliance Guided Individualized Positive End-expiratory Pressure on Postoperative Atelectasis After Laparoscopic Bariatric Surgery
Status: COMPLETED
Conditions: Postoperative Atelectasis
Interventions: PROCEDURE: Dynamic compliance guided individualized positive end-expiratory pressure titration strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Bioequivalence of Two Imiquimod Cream 3.75% Formulations in Patients With Actinic Keratosis.
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Imiquimod Topical Cream 3.75%|DRUG: Zyclara® (imiquimod) Topical Cream 3.75%|DRUG: Vehicle Topical Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Angioplasty in the Treatment of Chronic Cerebrospinal Venous Insufficiency (CCSVI) in Multiple Sclerosis
Status: TERMINATED
Conditions: Multiple Sclerosis
Interventions: PROCEDURE: Angioplasty|OTHER: Observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OSI-906 With Gemcitabine and Erlotinib for Metastatic Ductal Adenocarcinoma of the Pancreas
Status: WITHDRAWN
Conditions: Pancreatic Cancer, Metastatic
Interventions: DRUG: Gemcitabine, Erlotinib, OSI-906|DRUG: Gemcitabine, Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Fish Oil Supplementation on the Brain Health of Collegiate Football Athletes
Status: COMPLETED
Conditions: Traumatic Brain Injury (TBI)|Chronic Traumatic Encephalopathy (CTE)
Interventions: DIETARY_SUPPLEMENT: Fish Oil (DPA+EPA 2:1 ratio) Capsules|DIETARY_SUPPLEMENT: High Oleic Safflower Oil Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficacy of CANNABIDIOL on the Pruritus in Children With Hereditary Epidermolysis Bullosa
Status: COMPLETED
Conditions: Hereditary Epidermolysis Bullosa
Interventions: DRUG: Cannabidiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess the Safety and Tolerability of Tafasitamab Alone or in Combination With Other Drugs in Japanese Participants With Non-Hodgkins Lymphoma (NHL)
Status: RECRUITING
Conditions: Non Hodgkins Lymphoma|Diffuse Large B-cell Lymphoma
Interventions: DRUG: tafasitamab|DRUG: lenalidomide|DRUG: parsaclisib|DRUG: R-CHOP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Clinical Research of Anti-CD20 CAR-T Cells in Patients With Refractory or Relapsed B Lymphocyte Lymphoma
Status: UNKNOWN
Conditions: Relapsed or Refractory B-cell Lymphomas
Interventions: DRUG: CD20 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of SEA-TGT (SGN-TGT) in Advanced Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer|Gastric Carcinoma|Gastroesophageal Junction Carcinoma|Classical Hodgkin Lymphoma|Diffuse Large B-cell Lymphoma|Peripheral T-cell Lymphoma|Cutaneous Melanoma|Head and Neck Squamous Cell Carcinoma|Bladder Cancer|Ovarian Cancer|Triple Negative Breast Cancer|Cervical Cancer
Interventions: DRUG: SEA-TGT|DRUG: sasanlimab|DRUG: brentuximab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of HIV Self-Test Kits to Increase Identification of HIV-Infected Individuals and Their Partners
Status: COMPLETED
Conditions: HIV Infections
Interventions: BEHAVIORAL: Optimized PITC|DIAGNOSTIC_TEST: Facility HIVST|DIAGNOSTIC_TEST: Index HIVST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: PVE/PVL Combined With DEB-TACE in the Treatment of Patients With Large and Unresectable Liver Cancer
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: DEB-TACE|PROCEDURE: PVL/PVE+DEB-TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Pharmacokinetics of Quetiapine Fumarate in Chinese Schizophrenic Patients
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: quetiapine fumarate extended-release|DRUG: quetiapine fumarate extended-release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy and Safety of Allium Ureteral Stent for Treating Refractory Ureteral Stricture
Status: RECRUITING
Conditions: Ureteral Stenosis|Hydronephrosis|Ureteral Stent Occlusion
Interventions: DEVICE: Allium ureteral stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laryngeal Mask Airway Versus Air Q Laryngeal Airway
Status: COMPLETED
Conditions: Airway Devices
Interventions: DEVICE: LMA group|DEVICE: AirQ group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Placebo Controlled Safety and Efficacy Study of INT131 Besylate in Type 2 Diabetes, With an Active Comparator
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: INT131 besylate|DRUG: Pioglitazone HCl|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Registry for Hemoperfusion of Covid-19 ICU Patients
Status: ENROLLING_BY_INVITATION
Conditions: COVID-19 Acute Respiratory Distress Syndrome|Viral Disease|Critical Illness|Multi Organ Failure|Systemic Inflammatory Response Syndrome|AKI - Acute Kidney Injury
Interventions: DEVICE: Hemoperfusion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Complete Occlusion of Coilable Aneurysms
Status: COMPLETED
Conditions: Intracranial Aneurysm
Interventions: DEVICE: Pipeline Embolization Device (PED)|DEVICE: Coil embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Significance of Antiviral Therapy for Unresectable Hepatitis B Virus-related Primary Liver Cancer
Status: COMPLETED
Conditions: Primary Liver Cancer
Interventions: DRUG: Entecavir|DRUG: conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interleukin-6 Receptor Inhibitor Sarilumab in Combination With Ipilimumab, Nivolumab and Relatlimab in Patients With Unresectable Stage III or Stage IV Melanoma
Status: RECRUITING
Conditions: Melanoma|Unresectable Melanoma
Interventions: DRUG: Sarilumab|DRUG: Ipilimumab Injection|DRUG: Nivolumab/Relatlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Tolerability of AXA1957 in Adolescent Subjects With Non-Alcoholic Fatty Liver Disease (NAFLD)
Status: TERMINATED
Conditions: NAFLD
Interventions: DIETARY_SUPPLEMENT: AXA1957|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Malaria Prevention on Health and Education in Kenyan Schoolchildren
Status: COMPLETED
Conditions: Anaemia|Malaria
Interventions: DRUG: Intermittent screening and treatment for malaria|BEHAVIORAL: Teacher training on literacy instruction|OTHER: IST plus literacy instruction programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Toy and Mask Use on Pain and Anxiety in Children
Status: RECRUITING
Conditions: Intravenous Catheterization
Interventions: PROCEDURE: Toy Group|PROCEDURE: Mask group with cartoon characters|PROCEDURE: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Weber B Ankle Fractures With Associated Posterior Malleolus Fracture
Status: RECRUITING
Conditions: Posterior Malleolus Fractures|Ankle Fractures|Syndesmotic Injuries|Patient Reported Outcome Measure|Treatment Outcome
Interventions: PROCEDURE: Fixation of the posterior malleolus fractures|PROCEDURE: Fixation of lateral and/or medial malleolus fractures|PROCEDURE: Syndesmotic fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Doses of Inhaled GSK1995057
Status: COMPLETED
Conditions: Respiratory Disorders
Interventions: DRUG: GSK1995057|PROCEDURE: bronchoalveolar lavage|DRUG: LPS|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Impact of Therapy Dog Presence on Pediatric Echocardiogram
Status: RECRUITING
Conditions: Dog Therapy
Interventions: BEHAVIORAL: Dog therapy only|BEHAVIORAL: Dog plus standard distraction tech|BEHAVIORAL: Standard distraction techniques only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Venous and Cerebral Glucose Microdialysis in Neurocritical Care: Validation & Correlation
Status: UNKNOWN
Conditions: Traumatic Brain Injury|Acquired Brain Injury|Intracerebral Hemorrhage|Subarachnoid Hemorrhage|Ischemic Stroke
Interventions: DEVICE: MicroEye & ContinuMon
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dexamethasone for Symptom Burden in Advanced Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumors
Interventions: DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact Of Closure Of Patent Foramen Ovale On Apnoea-Hypopnoea-Index, Nocturnal Hypoxemia And Systemic Vascular Function In Patients With Obstructive Sleep Apnoea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: PFO Closure
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Effectiveness of Electro-Press Needle for Menopause-associated Hot Flashes
Status: UNKNOWN
Conditions: Hot Flashes|Acupuncture Therapy|Perimenopausal Disorder|Postmenopausal Symptoms
Interventions: DEVICE: Electro Press needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of a Macintosh Laryngoscope and Endotracheal Tube Introducer in a Manikin
Status: COMPLETED
Conditions: Difficult Intubation
Interventions: DEVICE: Endotracheal tube introducer|DEVICE: Macintosh laryngoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Clinical Evaluation of the One-Piece Tecnis Multifocal Intraocular Lens (IOL)
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: One-Piece Tecnis Multifocal IOL|DEVICE: One-Piece Tecnis monofocal IOL, Model ZCB00
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enteroadsorbent Polymethylsiloxane vs Probiotic Lactobacillus Reuteri in the Treatment of Rotaviral Gastroenteritis
Status: COMPLETED
Conditions: Rotavirus Gastroenteritis
Interventions: DIETARY_SUPPLEMENT: Polymethylsiloxane|DIETARY_SUPPLEMENT: Lactobacillus reuteri
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EPstein-barr Virus DNA Response to Systemic Therapy for Treatment Adaptation in High Risk NPC (EP-STAR)
Status: ACTIVE_NOT_RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: sintilimab|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Femtosecond Laser Arcuate Keratotomy Versus Toric Intraocular Lens Implantation in Cataract Surgery
Status: RECRUITING
Conditions: Cataract|Astigmatism
Interventions: PROCEDURE: Femtosecond laser arcuate keratotomy|PROCEDURE: Toric intraocular lens implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Understanding Mechanisms of Normal and Disordered Defecation
Status: RECRUITING
Conditions: Constipation
Interventions: DIAGNOSTIC_TEST: Rectal Barostat Study|DIAGNOSTIC_TEST: Fecoflowmetry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Chemotherapy Based on Positron Emission Tomography Scan in Treating Patients With Stage I or Stage II Hodgkin Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: Bleomycin Sulfate|DRUG: Doxorubicin Hydrochloride|DRUG: Procarbazine Hydrochloride|DRUG: Vinblastine Sulfate|DRUG: Dacarbazine|DRUG: Cyclophosphamide|DRUG: Etoposide phosphate|DRUG: prednisone|DRUG: Radiation Therapy|RADIATION: Fludeoxyglucose F-18|PROCEDURE: computed tomography|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Injection Site Pain Experience After the Injection of 2 Different Solutions of Semaglutide With 2 Different Injection Pens, a Compound for the Treatment of Type 2 Diabetes and Obesity
Status: COMPLETED
Conditions: Healthy Volunteers Diabetes Mellitus, Type 2|Healthy Volunteers Overweight|Healthy Volunteers Obesity
Interventions: DRUG: Semaglutide (administered by DV3396 pen)|DRUG: Semaglutide (administered by PDS290 pen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Evaluation of the RheOx Bronchial Rheoplasty System
Status: RECRUITING
Conditions: Chronic Bronchitis|Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: RheOx™ with the RheOx™ Catheter treated in the trial
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of High Intensity Focused Ultrasound in Solar Lentigo: A Self-controlled Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Solar Lentigo
Interventions: DEVICE: High intensity focused ultrasound (MFUS One, Hunan Peninsula Medical Technology Co., Ltd., China)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: LCI-HEM-MYE-CRD-004 (MMRC-073 CARJAK): Study of CRD for Carfilzomib-Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Carfilzomib|DRUG: Ruxolitinib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant vs. Intraoperative vs. Adjuvant Resection Cavity Radiotherapy of Brain Metastases
Status: RECRUITING
Conditions: Brain Metastases|Radiotherapy
Interventions: RADIATION: Preoperative Radiotherapy|RADIATION: Intraoperative Radiation|RADIATION: Postoperative Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase Ib/IIa Trial With AC01 in Patients With HFrEF
Status: RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: AC01
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Of Three PF-05190457 Formulations In Healthy Volunteers
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: PF-05190457|DRUG: PF-05190457|DRUG: PF-05190457|DRUG: PF-05190457|DRUG: PF-05190457|DRUG: PF-05190457|DRUG: PF-05190457|DRUG: PF-05190457
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Non Opioid Treatment for Experimental Dyspnea
Status: COMPLETED
Conditions: Dyspnea|Pain
Interventions: DRUG: Nefopam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Controlled Study on the Efficacy of Denosumab in Treating Osteoporosis in the Domestic Population and Its Impact on Sarcopenia-related Outcomes
Status: RECRUITING
Conditions: Sarcopenia|Osteoporosis|Denosumab
Interventions: DRUG: Denosumab Injection|OTHER: Normal saline injection (1.0ml/ branch)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of the SGLT2-inhibitor Empagliflozin on Patients With SIADH - the SAND Study
Status: COMPLETED
Conditions: SIADH
Interventions: DRUG: Empagliflozin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-acting Injectable Antipsychotics for Mental Ill-Health in Pregnancy and Postpartum
Status: RECRUITING
Conditions: Schizophrenia|Psychosis|Mania|Pregnancy|Drug Exposure in Utero|Drug Exposure Via Breast Milk|Antipsychotic Agents|Breastfeeding
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p