pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Circulating Tumor DNA and T Cell Repertoire Predict Radiotherapeutic Outcomes in NSCLC Patients With Brain Metastasis
Status: NOT_YET_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung|Brain Metastases
Interventions: RADIATION: Whole-brain radiotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate Safety and Toxicity of Polyphenon E (EGCG) in HIV-1-Infected Individuals
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: Polyphenon E|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment for Alcoholism and Post-Traumatic Stress Disorder (Naltrexone)
Status: COMPLETED
Conditions: Alcoholism|Alcohol Dependence|Post-Traumatic Stress Disorder
Interventions: BEHAVIORAL: Cognitive-Behavioral Therapy|DRUG: Naltrexone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Efficacy of Rifamycin SV Multi-Matrix System (MMX) for the Treatment of Traveler's Diarrhea (TD)
Status: COMPLETED
Conditions: Traveler's Diarrhea
Interventions: DRUG: Placebo|DRUG: Rifamycin SV MMX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Pressure Support Ventilation During Anesthetic Emergence on Postoperative Atelectasis in Infant
Status: UNKNOWN
Conditions: Infants Aged 0 Days to 13 Months Scheduled for Elective Surgery
Interventions: OTHER: conventional ventilation, group C|OTHER: pressure support, group PS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of Strontium90 Beta Radiation With Lucentis to Treat Age-Related Macular Degeneration
Status: UNKNOWN
Conditions: Macular Degeneration
Interventions: DEVICE: Epi-Rad90™ Ophthalmic System|DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Videoconferencing Adapted Physical Activity in Anorexia Nervosa: a Pilot Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Anorexia Nervosa|Exercise Therapy|Videoconferencing
Interventions: OTHER: Adapted Physical Activity (APA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Efficacy and Safety Study of Simeprevir and Sofosbuvir With and Without Ribavirin in Participants With Recurrent Genotype 1 Hepatitis C Post-Orthotopic Liver Transplant
Status: COMPLETED
Conditions: Hepatitits C
Interventions: DRUG: Simeprevir|DRUG: Sofosbuvir|DRUG: Ribavirin|DRUG: Simeprevir|DRUG: Sofosbuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeting MDMD and PD1 in Tumors With Tertiary Lymphoid Structures
Status: NOT_YET_RECRUITING
Conditions: Adult Soft Tissue Sarcoma|Non Small Cell Lung Cancer|Triple Negative Breast Cancer|Colorectal Cancer|Biliary Tract Cancer
Interventions: DRUG: Ezabenlimab + BI907828
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Recombinant Growth Hormone on Muscle Function in Children Long-term Treated With Glucocorticoid
Status: COMPLETED
Conditions: Chronic Disease|Glucocorticoid Therapy, Response to|Growth Retardation
Interventions: DEVICE: GH treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First in Human Study of AX-202 in Healthy Subjects and Patients With Psoriasis.
Status: RECRUITING
Conditions: Healthy Volunteers|Mild to Moderate Psoriasis
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: AX-202
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Plantar Fasciopathy and the Effectiveness of Radial Extracorporeal Shockwave Therapy, Physical Training or Usual Care
Status: COMPLETED
Conditions: Plantar Fascitis
Interventions: DEVICE: Radial extracorporeal shock wave|DEVICE: Sham-radial extracorporeal shock wave|BEHAVIORAL: Standardized high-load exercise program|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer
Status: COMPLETED
Conditions: Anxiety Disorder|Depression|Fatigue|Leydig Cell Tumor|Ovarian Sarcoma|Ovarian Stromal Cancer|Pain|Peritoneal Carcinomatosis|Pseudomyxoma Peritonei|Recurrent Breast Cancer|Recurrent Cervical Cancer|Recurrent Endometrial Carcinoma|Recurrent Fallopian Tube Cancer|Recurrent Gestational Trophoblastic Tumor|Recurrent Ovarian Epithelial Cancer|Recurrent Ovarian Germ Cell Tumor|Recurrent Primary Peritoneal Cavity Cancer|Recurrent Uterine Sarcoma|Recurrent Vaginal Cancer|Recurrent Vulvar Cancer
Interventions: OTHER: questionnaire administration|PROCEDURE: quality-of-life assessment|PROCEDURE: psychosocial assessment and care|BEHAVIORAL: behavioral intervention|OTHER: cognitive intervention|OTHER: educational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PREGBRAIN - Magnetic Stimulation of the Brain in Depressed Pregnant Women
Status: WITHDRAWN
Conditions: Depression|Pregnancy Related
Interventions: DEVICE: iTBS (intermittent theta-burst stimulation)|DEVICE: Sham iTBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Follow-up of Early Breast Cancer by Dynamic Evaluation of CEA and CA 15.3 Followed by 18FDG-PET
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: OTHER: Arm B, tumor markers assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Epigenetic Regulation of Exercise Induced Asthma
Status: UNKNOWN
Conditions: Exercise Induced Asthma|House Dust Mite Allergy
Interventions: DIAGNOSTIC_TEST: Exercise challenge in the cold chamber (ECC)|DIAGNOSTIC_TEST: mRNA profile|DIAGNOSTIC_TEST: standard diagnostic
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination of Lenalidomide and Dexamethasone in Treatment of Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide, Dexamethasone|DRUG: Lenalidomide, Dexamethasone, PBSCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization of the Nursing Time After the Use of Tissue Adhesives During the Chest Port Placement on Patients Treated With Chemotherapy Versus Sutures
Status: COMPLETED
Conditions: Cancer
Interventions: PROCEDURE: Skin Adhesive procedure|PROCEDURE: Standard suture procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol
Status: COMPLETED
Conditions: Anxiety Disorders|Depression|Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: COGENT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy Alone Versus Concurrent Chemoradiation in Low Risk NK/T-cell Lymphoma
Status: TERMINATED
Conditions: Extranodal NK/T-cell Lymphoma, Nasal Type
Interventions: RADIATION: Radiotherapy alone|DRUG: Concurrent chemoradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multidimensional Rehabilitation Intervention in Colorectal Cancer Survivors - a Pilot Study
Status: NOT_YET_RECRUITING
Conditions: Rehabilitation|Colorectal Cancer Survivor|Quality of Life|Pilot Study
Interventions: BEHAVIORAL: multidimensional rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Development of 'Emma'--a Pediatric IBD Quiz
Status: COMPLETED
Conditions: Ulcerative Colitis|Crohn's Disease|Inflammatory Bowel Disease
Interventions: OTHER: playing the ipad quiz game
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Quadratus Lumborum Block Versus Transversus Abdominis Plane Block in Patients Undergoing Left Hemicolectomy
Status: UNKNOWN
Conditions: Colon Neoplasm|Surgery|Pain, Postoperative
Interventions: PROCEDURE: Left hemicolectomy, laparoscopic technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of Three Dosage Strengths of Pulsatile GnRH Delivered From a Iontophoretic Patch Compared to Oral Treatment With Clomiphene or Placebo in Infertile Females
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: GnRH iontophoretic transdermal Lutrepatch|DRUG: GnRH iontophoretic transdermal Lutrepatch|DRUG: GnRH iontophoretic transdermal Lutrepatch|DRUG: clomiphene citrate|DRUG: placebo clomiphene citrate|DRUG: placebo GnRH patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Effects of Two Different Balance Systems on the Balance, Posture and Functionality in Stroke Patients
Status: ENROLLING_BY_INVITATION
Conditions: Chronic Stroke
Interventions: OTHER: TechnoBody|OTHER: Thera-Trainer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study to Determine the Pharmacokinetic and Pharmacodynamic Profiles of PROCRIT (Epoetin Alfa) in Anemic Patients With Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease|Anemia
Interventions: DRUG: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Piloting a Web Resource for Pregnancy OUD in Jail
Status: RECRUITING
Conditions: Opioid Use Disorder
Interventions: OTHER: Maternal Opioid use Disorder Management and Care Resources (MOM CARE) in Custody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Investigating the Effects of Dietary Nitrate on Vascular Function, Platelet Reactivity and Restenosis in Stable Angina
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases
Interventions: DIETARY_SUPPLEMENT: Beetroot Juice|DIETARY_SUPPLEMENT: Beetroot Juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Fish Oil on Post Ablation Arrhythmias
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: DRUG: LOVAZA Omega 3-acid ethyl esters|DRUG: LOVAZA|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: FLT-PET for Early Detection of Relapse in Patients With Irradiated Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer, Nonsmall Cell|Small Cell Lung Cancer
Interventions: DEVICE: FLT-PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase 1 Thorough QT (TQT) Study in Young Healthy Volunteers
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: esreboxetine|DRUG: placebo|DRUG: moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety Study of MDV9300 in Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL)
Status: WITHDRAWN
Conditions: Lymphoma, Large B-Cell, Diffuse|Primary Mediastinal Large B-cell Lymphoma|Transformed Indolent Lymphoma
Interventions: BIOLOGICAL: MDV9300
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Pre-operative Prescription Delivered During Anesthesia Consultation or Post-operative Prescription
Status: UNKNOWN
Conditions: Postoperative Pain|Ambulatory Surgery|Anesthesia|Postoperative Complication
Interventions: OTHER: Comparison between pre-operative prescription and post-operative prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Phosphate Binding in Healthy Volunteers: Chewed Versus Crushed Lanthanum Carbonate
Status: COMPLETED
Conditions: Hyperphosphatemia in Chronic Kidney Disease
Interventions: DRUG: Lanthanum carbonate (chewed vs. crushed)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Bioavailability Study of 3 Test Tablet Formulations of Bazedoxifene Compared With A Reference Tablet Formulation of Bazedoxifene/Conjugated Estrogens in Healthy Postmenopausal Women
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: bazedoxifene|DRUG: bazedoxifene|DRUG: bazedoxifene|DRUG: bazedoxifene/conjugated estrogens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety Study of an Intravenous Staphylococcus Aureus Immune Globulin (Human), [Altastaph] in Low-Birth-Weight-Neonates
Status: COMPLETED
Conditions: Staphylococcal Infections
Interventions: DRUG: Staphylococcus aureus Immune Globulin (Human) 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Docetaxel Chemotherapy and Pembrolizumab Plus Interleukin-12 Gene Therapy in Triple Negative Breast Cancer
Status: SUSPENDED
Conditions: Triple Negative Breast Cancer|Anthracycline-refractory TNBC
Interventions: DRUG: Docetaxel|DRUG: Pembrolizumab|DRUG: IL-12 gene therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Two Different Doses of Intrathecal Dexmedetomidine as Adjuvant in Elderly Patients Undergoing HoLEP
Status: RECRUITING
Conditions: Transurethral Resection of Prostate
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: External Lid Loading for the Temporary Treatment of the Paresis of the M. Orbicularis Oculi: a Clinical Note
Status: COMPLETED
Conditions: Incomplete Closure of Lid|Parotis Tumor|m. Orbicularis Oculi Paresis
Interventions: OTHER: individually tailored lead weight
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Chemotherapy With or Without Idarubicin and Peripheral Stem Cell Transplantation in Treating Patients With Leukemia or Myelodysplastic Syndrome
Status: UNKNOWN
Conditions: Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
Interventions: DRUG: busulfan|DRUG: cyclophosphamide|DRUG: idarubicin|DRUG: melphalan|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Post-market Clinical Follow-up (PMCF) Study of the Poly-Tape Device for Medial Patellofemoral Ligament (MPFL) Reconstruction
Status: RECRUITING
Conditions: Medial Patellofemoral Dislocation
Interventions: DEVICE: Poly-Tape
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CBAS180 De-escalation Study
Status: RECRUITING
Conditions: Barrett's Esophagus|Ablation Therapy|Cryotherapy|Cryoballoon Ablation
Interventions: DEVICE: C2 CryoBalloon 180° Ablation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aripiprazole Used as Dual Therapy in the Treatement of Patients With Chronic Stable Schizophrenia or Schizoaffective Disorder.
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Quetiapine or Risperidone + Aripiprazole|DRUG: Quetiapine or Risperidone + placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of a CA-CBI on Psychological Distress of University Students During the COVID-19 Pandemic
Status: COMPLETED
Conditions: Psychological Distress|Well-being
Interventions: BEHAVIORAL: Culturally Adapted Cognitive Behavioral Intervention (CA-CBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Estromineral Serena Plus and Symptomatic Menopause
Status: UNKNOWN
Conditions: Menopause
Interventions: DIETARY_SUPPLEMENT: Estromineral Serena Plus|DIETARY_SUPPLEMENT: Estromineral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Flow Nasal Cannula in Patients Undergoing ERCP Retrograde Cholangiopancreatography With Intravenous Sedation.
Status: RECRUITING
Conditions: High-flow Nasal Cannula|Intravenous Sedation
Interventions: DEVICE: High flow nasal cannula (15 L/m)|DEVICE: High flow nasal cannula (30 L/m)|DEVICE: High flow nasal cannula (60 L/m)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Photodynamic Therapy in Treating Patients With Cutaneous T-Cell Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: DRUG: bexarotene|DRUG: methoxsalen|PROCEDURE: UV light therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Relative Bioavailability of 4 New Abiraterone Acetate Tablet Formulations With Respect to the Current Commercial Abiraterone Acetate Tablet Under Fasted Conditions in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Treatment A|DRUG: Treatment B|DRUG: Treatment C|DRUG: Treatment D|DRUG: Treatment E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Understand the Effect of a Study Medicine Called ARV-471 on Dabigatran Etexilate in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ARV-471|DRUG: Dabigatran etexilate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluating Efgartigimod in Patients With Guillain-Barré Syndrome
Status: RECRUITING
Conditions: Guillain-Barre Syndrome
Interventions: DRUG: Efgartigimod Alfa-Fcab|DRUG: Intravenous Immunoglobulin (IVIg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of a Long Acting GLP-1 Analogue (NNC0113-0987) in Healthy Male Subjects
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: NNC0113-0987|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Combination of Cetuximab and Chemotherapy as Neoadjuvant Therapy Followed Concomitant Chemoradiotherapy Plus Cetuximab in Locoregional Esophageal Carcinoma
Status: COMPLETED
Conditions: Esophageal Carcinoma
Interventions: DRUG: cetuximab and chemotherapy (docetaxel, cisplatin, 5-fluorouracil)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interventions To Help Asthma Clinical Adherence
Status: COMPLETED
Conditions: Asthma in Children|Humans|Hispanic Americans|Child
Interventions: DEVICE: SmartInhaler with reminder function turned on|DEVICE: SmartInhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Human Aging and in Vivo Noradrenergic System
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: OTHER: The role of the noradrenergic system across the life span (Healthy Subjects)|OTHER: The role of the noradrenergic system across the life span (Parkinson's Disease Subjects)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Proactive, Personalized Postpartum Mental Healthcare
Status: COMPLETED
Conditions: Postpartum Depression|Postpartum Blues|Postpartum Anxiety|Postpartum Mood Disorder
Interventions: BEHAVIORAL: Usual care plus eToolkit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Single-Dose Gene Replacement Therapy Clinical Trial for Participants With Spinal Muscular Atrophy Type 1
Status: COMPLETED
Conditions: SMA
Interventions: BIOLOGICAL: Onasemnogene Abeparvovec-xioi
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Versus Analogue Insulin for Youth With Type 1 Diabetes in Low-Resource Settings
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 1|Type 1 Diabetes
Interventions: DRUG: Insulin Glargine|DRUG: NPH or premixed 70/30 (human insulin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VAY736 in Relapsed or Refractory CLL Patients
Status: TERMINATED
Conditions: Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)
Interventions: DRUG: VAY736
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interleukin-12 in Treating Patients With Ovarian Epithelial Cancer or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer
Interventions: BIOLOGICAL: recombinant interleukin-12
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Statins in the Prevention of Contrast-induced Acute Kidney Injury in Patients With Cardiovascular Diseases
Status: COMPLETED
Conditions: Contrast-induced Acute Kidney Injury|Cardiovascular Diseases
Interventions: DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Open Phase 3 Study of IV-Globulin SN Inj.10% to Treat Immune Thrombocytopenia
Status: COMPLETED
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Human immunoglobulin intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of Vitamin D Supplementation to Pregnant Women and Their Infants in Pakistan.
Status: COMPLETED
Conditions: Vitamin D Deficiency|Pre Eclampsia|Stillbirths|Low Birth Weight|Prematurity
Interventions: DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Resin Infiltration Treatment for MIH
Status: COMPLETED
Conditions: Molar Incisor Hypomineralization|Enamel Hypoplasia|Enamel Caries|Anterior Teeth
Interventions: PROCEDURE: Resin infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NIV - NAVA vs NIV - PS for COPD Exacerbation
Status: COMPLETED
Conditions: COPD Exacerbation
Interventions: DEVICE: Neurally Adjusted Ventilator Assist|DEVICE: Pressure support ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Remote Ischaemic PreConditioning (RIPC) in Partial Nephrectomy for the Prevention of Ischemia/Reperfusion Injury
Status: UNKNOWN
Conditions: Reperfusion Injury
Interventions: PROCEDURE: RIPC|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Utility of Contrast-Enhanced Sonography and Shear Wave Elastography
Status: TERMINATED
Conditions: Thyroid Nodule
Interventions: OTHER: Contrast-enhanced ultrasound|OTHER: Shear Wave Elastography|DEVICE: Sequoia System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: VX-950-TiDP24-C134: Drug-drug Interaction Trial Between Combination of Efavirenz and Tenofovir Disoproxil Fumarate and Different Dosages of Telaprevir on Healthy Volunteer
Status: COMPLETED
Conditions: Hepatitis C|HCV|HIV|AIDS
Interventions: DRUG: Efavirenz; Tenofovir disoproxil fumarate; Telaprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of 23-gauge Lensecotomy Combined With Anterior Vitrectomy on Macular in Children With Congenital Cataract
Status: COMPLETED
Conditions: Macular|Congenital Cataract
Interventions: PROCEDURE: cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Oral Nutritional Supplement on Nutritional and Functional Status, and Biomarkers in Malnourished Hemodialysis Patients.
Status: COMPLETED
Conditions: Malnutrition|End Stage Renal Disease
Interventions: DIETARY_SUPPLEMENT: Oral nutritional supplement with probiotics|DIETARY_SUPPLEMENT: Oral nutritional supplement without probiotics|OTHER: Dietary recommendations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pemigatinib for FGF/FGFR Alterations Advanced Pan Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor|FGF Receptor Gene Mutation|FGF Amplification|FGF Receptor Gene Family Rearrangement|FGF Receptor Gene Translocation
Interventions: DRUG: Pemigatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Children With Non-testicular Malignant Germ Cell Tumors
Status: COMPLETED
Conditions: Extragonadal Germ Cell Tumor|Ovarian Cancer
Interventions: BIOLOGICAL: dactinomycin|BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: leucovorin calcium|DRUG: methotrexate|DRUG: vincristine sulfate|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Anti-PD-1 Antibody and Pegaspargase Combined With Radiotherapy in Early-Stage ENKTL
Status: NOT_YET_RECRUITING
Conditions: Extranodal NK/T-cell Lymphoma, Nasal Type
Interventions: DRUG: Pegaspargase|DRUG: Anti-PD-1 monoclonal antibody|RADIATION: Definitive intensity-modulated radiotherapy (IMRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study Of The Bionode System In Subjects With Elevated IOP
Status: UNKNOWN
Conditions: Unmedicated IOP Before and After Treatment
Interventions: DEVICE: Bionode IOP Lowering System|DEVICE: Bionode IOP Lowering System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tumor Treating Fields (TTFields) (150 kHz) Concurrent With Standard of Care Therapies for Treatment of Stage 4 Non-small Cell Lung Cancer (NSCLC) Following Platinum Failure (LUNAR)
Status: ACTIVE_NOT_RECRUITING
Conditions: Nonsmall Cell Lung Cancer|NSCLC
Interventions: DEVICE: NovoTTF-200T|DRUG: Immune checkpoint inhibitors or docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Study of OnabotulinumtoxinA Treatment in Adult Patients With Upper Limb Spasticity
Status: WITHDRAWN
Conditions: Muscle Spasticity|Stroke
Interventions: BIOLOGICAL: onabotulinumtoxinA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Leronlimab in Patients With Coronavirus Disease 2019 (COVID-19) With Need for Mechanical Ventilation or Extracorporeal Membrane Oxygenation
Status: SUSPENDED
Conditions: COVID-19 Pneumonia
Interventions: DRUG: Leronlimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Trial of an Investigational Small Pox Medication
Status: COMPLETED
Conditions: Orthopoxviral Disease|Smallpox|Monkey Pox
Interventions: DRUG: ST-246 Days 1 - 3|DRUG: ST-246 Days 11 - 13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adoptive Transfer of MART1/Melan-A CTL for Malignant Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: therapeutic autologous lymphocytes|GENETIC: Use of an artificial antigen presenting cell (aAPC) to generate CTL|DRUG: GM-CSF|RADIATION: Irradiation of cutaneous tumor lesion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Lactoferrin Supplementation for Prevention of Sepsis in Preterm Neonate
Status: UNKNOWN
Conditions: Neonatal Sepsis
Interventions: DIETARY_SUPPLEMENT: Lactoferrin|DIETARY_SUPPLEMENT: Lactoferrin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Antineoplaston Therapy in Treating Patients With Advanced Head and Neck Cancer
Status: TERMINATED
Conditions: Head and Neck Cancer
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bryostatin 1 and Cisplatin in Treating Patients With Metastatic or Unresectable Stomach Cancer
Status: COMPLETED
Conditions: Stage III Gastric Cancer|Stage IV Gastric Cancer
Interventions: DRUG: bryostatin 1|DRUG: cisplatin|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects Of Native Collagen Type 2 Treatment
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: paracetamol|DRUG: paracetamol+native collagen type 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of the Safety and Effectiveness of the Sight Sciences VISCO™360 Viscosurgical System Versus SLT in Primary Open Angle Glaucoma (VISCO360 Study)
Status: TERMINATED
Conditions: Open-Angle Glaucoma
Interventions: DEVICE: VISCO360 ab interno canaloplasty surgery|DEVICE: Selective Laser Trabeculoplasty (SLT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: tDCS for Impulsivity and Compulsivity in Obesity
Status: COMPLETED
Conditions: Impulsivity|Compulsive Overeating|Obesity
Interventions: DEVICE: Device: Active Transcranial Direct Current Stimulation (tDCS) coupled with cognitive training|DEVICE: Device: Sham Transcranial Direct Current Stimulation (tDCS) coupled with cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Truvada Versus Truvada Plus Hepatitis B Immunoglobulin (HBIg) in Prevention of Chronic Hepatitis B Recurrence Post Liver Transplant
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: FTC/TDF|DRUG: Hepatitis B Immunoglobulin (HBIg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Long Term Safety of Vedolizumab (MLN0002) in Patients With Ulcerative Colitis and Crohn's Disease
Status: COMPLETED
Conditions: Ulcerative Colitis|Crohn's Disease
Interventions: DRUG: vedolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BCMA/CD19 Dual-Target CAR-T Cell Immunotherapy for Relapsed or Refractory MM
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: BCMA/CD19 dual-target CAR-T cell immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Combination of BKM120 and Cisplatin or Carboplatin in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: BKM120-CIS|DRUG: BKM120-CARBO
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Segmental Resection Combined With DEP Regimen for EBV-HLH Patients With Intestinal Involvement
Status: NOT_YET_RECRUITING
Conditions: Hemophagocytic Lymphohistiocytosis|Epstein-Barr Virus|Bowel Resection
Interventions: OTHER: Segmental bowel resection combined with the DEP regimen
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Tolerability of IRX-101 in Patients Receiving Intravitreal Injections
Status: RECRUITING
Conditions: Retinal Disease
Interventions: DRUG: IRX-101|DRUG: Providone-Iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Point-of-Care Testing (POCT) Detection and Management of Metabolic Syndrome in Patients With Mental Illness
Status: COMPLETED
Conditions: Hyperlipidemia|Diabetes|Hypertension
Interventions: DEVICE: Glucose and lipids|DEVICE: Glycosylated Hemoglobin A1c|DEVICE: Blood Pressure and Heart Rate|DEVICE: Body mass index|DEVICE: Waist and Hip circumference|BEHAVIORAL: Comprehensive Medication Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: mFOLFOX7 Plus Camrelizumab and Apatinib for Advanced HCC
Status: RECRUITING
Conditions: Stage III Hepatocellular Cancer (CNLC Staging)
Interventions: DRUG: mFOLFOX7+Camrelizumab+Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuroimaging Mechanisms by Which Memory and Glucocorticoids Promote Risky Drinking
Status: COMPLETED
Conditions: Alcohol Drinking|Drinking Behavior|Episodic Memory|Long-term Memory
Interventions: DRUG: Hydrocortisone 20 MG|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Hyaluronic Acid on the Therapy of Alveolar Osteitis
Status: UNKNOWN
Conditions: Alveolar Osteitis
Interventions: DEVICE: Hyaluronic acid gel|DEVICE: Hyaluronic acid gel + carrier
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sintilimab in Combination With R-CHOP in Patients With Treatment-naive EBV-positive DLBCL, NOS
Status: UNKNOWN
Conditions: EBV-Positive DLBCL, Nos
Interventions: DRUG: Sintilimab|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IV Dosage Form of LCB01-0371 Phase I Study in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LCB01-0371|DRUG: LCB01-0371 400mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Appaconitine Patch for Oral Mucositis Pain Caused by Chemoradiotherapy in Patients With Nasopharyngeal Cancer
Status: UNKNOWN
Conditions: Radiation Induced Oral Mucositis
Interventions: DRUG: Lappaconitine Adhesive Patch|DRUG: standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3D vs 2D HD Laparoscopy in Cholecystectomy
Status: COMPLETED
Conditions: Cholecystolithiasis
Interventions: PROCEDURE: 2D laparoscopic cholecystectomy|PROCEDURE: 3D laparoscopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes
Status: COMPLETED
Conditions: Acute Otitis Media
Interventions: DRUG: Moxidex otic solution|DRUG: Moxifloxacin otic solution|DEVICE: Tympanostomy tubes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Subcutaneous Hydrocortisone Infusion In Addison's Disease and Type 1 Diabetes
Status: TERMINATED
Conditions: Addison Disease|Type 1 Diabetes
Interventions: OTHER: Cortef|OTHER: Solu-cortef
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fludeoxyglucose F-18-PET in Planning Lung Cancer Radiation Therapy
Status: COMPLETED
Conditions: Stage I Lung Cancer|Stage I Non-Small Cell Lung Cancer AJCC v7|Stage IA Non-Small Cell Lung Carcinoma AJCC v7|Stage IB Non-Small Cell Lung Carcinoma AJCC v7|Stage II Lung Cancer|Stage II Non-Small Cell Lung Cancer AJCC v7|Stage IIA Non-Small Cell Lung Carcinoma AJCC v7|Stage IIB Non-Small Cell Lung Carcinoma AJCC v7
Interventions: DRUG: Fludeoxyglucose F-18|PROCEDURE: Positron Emission Tomography (PET)|RADIATION: Stereotactic Body Radiation Therapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of Familiar Toy and Parental Presence Combination on Perioperative Pediatric Anxiety
Status: RECRUITING
Conditions: Perioperative Anxiety|Emergence Delirium
Interventions: BEHAVIORAL: Selection of the parent according to children preference|BEHAVIORAL: Bringing the favorite toy of the children that will accompany the child during their perioperative period
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reducing Dementia Risk With Digital Health Coaching
Status: UNKNOWN
Conditions: Alzheimer Disease|Dementia|Mild Cognitive Impairment|Cognitive Decline
Interventions: BEHAVIORAL: MindMate + Health Coaching|OTHER: Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pembrolizumab in Combination With Plinabulin and Docetaxel For Metastatic NSCLC After ICIs (KeyPemls-004)
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer Metastatic
Interventions: DRUG: Pembrolizumab in Combination with Plinabulin and Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microvascular Coronary Disease In Women: Impact Of Ranolazine
Status: COMPLETED
Conditions: Myocardial Ischemia
Interventions: DRUG: Ranolazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of Inhaled Ciclesonide Versus Placebo in Children (6-11 Years) With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Ciclesonide|DRUG: Placebo|DRUG: Salbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized Vs. Standard Duration of Dual Antiplatelet Therapy and New-generation Polymer-Free vs- Biodegradable-Polymer DES
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease|Acute Coronary Syndrome|Chronic Coronary Syndrome|Myocardial Infarction
Interventions: DEVICE: Percutaneous coronary intervention with implantation of amphilimus-eluting stents for coronary artery disease.|DEVICE: Percutaneous coronary intervention with implantation of everolimus-eluting stents for coronary artery disease.|DRUG: Personalized DAPT duration|DRUG: Standard DAPT duration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Corticosteroids for Low Back Pain
Status: COMPLETED
Conditions: Radicular Low Back Pain
Interventions: DRUG: Intramuscular methylprednisolone acetate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Evaluation for Predicting the Complications Related to Gastric Conduit After Esophagectomy
Status: COMPLETED
Conditions: Esophageal Neoplasms|Constriction|Anastomotic Leak|Ischemia
Interventions: DIAGNOSTIC_TEST: Patients after esophagectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mechanisms of Sleep Disruption Hyperalgesia
Status: COMPLETED
Conditions: Sleep Deprivation|Pain
Interventions: DRUG: Morphine|DRUG: Saline Placebo|BEHAVIORAL: Forced Awakenings|BEHAVIORAL: Uninterrupted Sleep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Therapeutic ID93 + GLA-SE Vaccination in Participants With Rifampicin-Susceptible Pulmonary TB
Status: NOT_YET_RECRUITING
Conditions: Tuberculosis, Pulmonary
Interventions: BIOLOGICAL: ID93 + GLA-SE vaccine|BIOLOGICAL: Placebo vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of OSI-906 in Patients With Locally Advanced or Metastatic Adrenocortical Carcinoma
Status: COMPLETED
Conditions: Adrenocortical Carcinoma
Interventions: DRUG: OSI-906|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study With Photodynamic Therapy And Triamcinolone Versus Photodynamic Therapy, Triamcinolone And Ranibizumab In Patients With Subfoveal Choroidal Neovascularization
Status: WITHDRAWN
Conditions: Subfoveal Choroidal Neovascularization
Interventions: DRUG: intravitreal injection of ranibizumab|DRUG: intravitreal injection of triamcinolone|PROCEDURE: photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study to Evaluate the Penetration and Pharmacodynamic Effects of Baminercept in the Cerebrospinal Fluid (CSF)and Safety in Subjects With Secondary Progressive Multiple Sclerosis (SPMS)
Status: WITHDRAWN
Conditions: Secondary Progressive Multiple Sclerosis
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: Baminercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate Safety, Tolerance and Pharmacokinetics of JX11502MA Capsule in Patients With Schizophrenia.
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: JX11502MA|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT