pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Clinical Efficacy of Non-steroidal Anti-inflammation Drugs in Patients With Benign Prostatic Hyperplasia
Status: WITHDRAWN
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: selective alpha 1-blockers|DRUG: celecoxib|DRUG: alpha-blocker and NSAID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 17-N-Allylamino-17-Demethoxygeldanamycin With or Without Rituximab in Treating Patients With Relapsed B-Cell Chronic Lymphocytic Leukemia or Prolymphocytic Leukemia
Status: TERMINATED
Conditions: B-cell Chronic Lymphocytic Leukemia|Prolymphocytic Leukemia|Refractory Chronic Lymphocytic Leukemia
Interventions: DRUG: tanespimycin|BIOLOGICAL: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PEC Block II in Mammoplasty Surgeries
Status: UNKNOWN
Conditions: Mammaplasty|Anesthesia, Conduction|Analgesia|Analgesia, Patient-Controlled
Interventions: DRUG: Normal Saline 0,9%|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Isometric Versus Isotonic Exercise in Female Patients With Osteoarthritis
Status: RECRUITING
Conditions: Osteoarthritis
Interventions: DIAGNOSTIC_TEST: Isometric|DIAGNOSTIC_TEST: Isotonic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Trial of Multisystemic Therapy in UK a Statutory Therapeutic Intervention for Young Offenders
Status: UNKNOWN
Conditions: Participants Are Male and Female Adolescents 13-16 Years at Risk for Continuing to Commit Criminal Offences.
Interventions: OTHER: Multisystemic therapy|OTHER: YOT (usual services)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: KETOR: Effects of Peri Operative Administration of Ketamine on Long Term Post Thoracotomy Pain
Status: COMPLETED
Conditions: Ketamine|Chronic Post Thoracotomy Pain|Thoracotomy|Pain|Neuralgia
Interventions: DRUG: Ketamine (or placebo : isotonic saline solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Acceptability and Safety Study of Suboxone Induction in Heroin Users (P05042)(COMPLETED)
Status: COMPLETED
Conditions: Opiate Dependence|Drug Dependence|Substance Dependence
Interventions: DRUG: Suboxone (SCH 000484)|DRUG: Subutex (SCH 028444)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effect of Melatonin, Diazepam, and Placebo on Decreasing the Level of Anxiety Preoperatively
Status: COMPLETED
Conditions: Anxiety|Preoperative Anxiety
Interventions: DRUG: Placebo|DRUG: Diazepam|DRUG: Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Drug-Drug Interaction (DDI) Study of HDM1002 With Rifampicin and Itraconazole in Healthy Subjects
Status: NOT_YET_RECRUITING
Conditions: Healthy Adult Subject
Interventions: DRUG: HDM1002 and rifampicin|DRUG: HDM1002 and itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dipeptide Alanyl Glutamine and Postoperative Insulin Resistance in Colon Carcinoma Patients
Status: UNKNOWN
Conditions: Colon Carcinoma
Interventions: DRUG: Dipeptide Alanyl-Glutamine|DRUG: Placebo|DRUG: Dipeptide Alanyl-Glutamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics, and Hematopoietic Stem Cell Mobilization of TG-0054 Alone or in Combination With G-CSF in Patients With Multiple Myeloma, Non-Hodgkin Lymphoma or Hodgkin Disease
Status: COMPLETED
Conditions: Multiple Myeloma|Non-hodgkin's Lymphoma|Hodgkin's Disease
Interventions: DRUG: TG-0054
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of TOP1630 for Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: TOP1630 0.1% Ophthalmic Solution TID OU|DRUG: Placebo to TOP1630 0.1% Ophthalmic Solution TID OU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outcomes of Different Treatment Options in Chronic Venous Disease
Status: NOT_YET_RECRUITING
Conditions: Chronic Venous Disease
Interventions: PROCEDURE: Radiofrequency ablation using Closure fast|PROCEDURE: Aethoxysclerol|DRUG: Daflon|DEVICE: Compression stocking
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Targeting Bias to Reduce Disparities in End of Life Care
Status: RECRUITING
Conditions: Terminal Illness|Critical Illness
Interventions: BEHAVIORAL: Communication and Bias Mitigation Training|BEHAVIORAL: Communication skills training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: 6 Weeks Step Aerobics Training Among Females With Sedentary Life Style.
Status: COMPLETED
Conditions: Sedentary Lifestyle
Interventions: OTHER: Step Aerobics|OTHER: Aerobic exercise (Lower limb Cycling)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Structured Rehabilitation Program on Quality of Life in Rectal Cancer Patients- a Randomized Controlled Trial
Status: WITHDRAWN
Conditions: Quality of Life|Sexual Function|Urinary Incontinence|Anal Incontinence
Interventions: BEHAVIORAL: Structured Rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Behavioral Modification Program and Mirabegron to Improve Urinary Urgency in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Mirabegron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Retrospective Study of Toxicity and Outcome of High Dose Chemotherapy With Autologous Stem Cell Transplant in Patients With Non-Hodgkin Lymphoma (NHL).
Status: COMPLETED
Conditions: Non-Hodgkins Lymphoma
Interventions: PROCEDURE: Autologous stem cell transplant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Topical 5% Imiquimod Cream for Vulvar Paget's Disease
Status: COMPLETED
Conditions: Paget Disease, Extramammary
Interventions: DRUG: Imiquimod|DRUG: paracetamol|DRUG: lidocaine in Vaseline ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacitidine in Treating Patients With Newly Diagnosed Previously Untreated or Secondary Acute Myeloid Leukemia Who Are Unsuitable For Intensive Chemotherapy
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: azacytidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spencer's Muscle Energy Technique and Cyriax Deep Friction Massage on Adhesive Capsulitis
Status: COMPLETED
Conditions: Adhesive Capsulitis
Interventions: OTHER: Cyriax Deep Friction Massage|OTHER: Spencer Muscle energy technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-Based Relapse Prevention to Improve Medication Assisted Treatment Adherence and Drug-use Outcomes for Opioid Use Disorder
Status: RECRUITING
Conditions: Opioid-use Disorder
Interventions: BEHAVIORAL: Mindfulness-Based Relapse Prevention - Rolling Admission (MBRP-RA)|BEHAVIORAL: Treatment-As-Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of PembrolizumAb combiNeD With Cisplatin or carbOplatin and Etoposide in Treatment naïve Advanced meRkel Cell cArcinoma (MCC)
Status: NOT_YET_RECRUITING
Conditions: Merkel Cell Carcinoma
Interventions: DRUG: Pembrolizumab, Etoposide, Cisplatin or Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concordance Between Ultra-low Dose (ULD) and Standard Dose CT Scans in the Search for Traumatic Brain Injury
Status: UNKNOWN
Conditions: Head Injuries, Penetrating|Head Injuries, Closed
Interventions: RADIATION: Conventional dose AND ultra low-dose CT scanning in the search for cranial lesions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Vildagliptin Compared to Gliclazide in Drug Naive Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: vildagliptin|DRUG: Gliclazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pivotal Trial of a Digital Therapeutic for the Treatment of Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DEVICE: BT-001|OTHER: Physician-guided Standard of Care for type 2 diabetes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Steroids and Unfractionated Heparin in Critically Ill Patients With Pneumonia From COVID-19 Infection
Status: UNKNOWN
Conditions: Covid19|SARS-CoV Infection|Pneumonia, Viral|Coagulopathy
Interventions: DRUG: Enoxaparin|DRUG: Methylprednisolone|DRUG: unfractionated heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Fentanyl With Topical Levobupivacaine With Nasal Packing in Endoscopic Nasal Surgery
Status: UNKNOWN
Conditions: Analgesia During Removal of Nasal Pack After Nasal Surgery
Interventions: DRUG: Fentanyl + Topical Levobupivacaine|DRUG: levobupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Edwards Cardioband European Post-Market Study, MiBAND
Status: ACTIVE_NOT_RECRUITING
Conditions: Mitral Regurgitation|Mitral Insufficiency|Mitral Repair|Mitral Valve|Annuloplasty|Edwards Cardioband
Interventions: DEVICE: Edwards Cardioband System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: GrandMove Project to Promote Elders' Robustness Against Frailty
Status: COMPLETED
Conditions: Frail Elderly Syndrome
Interventions: BEHAVIORAL: Resistance exercise (R)|BEHAVIORAL: Aerobic exercise (A)|BEHAVIORAL: Healthy lifestyle education (E)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Time-Restricted Eating to Address Persistent Cancer-Related Fatigue
Status: ACTIVE_NOT_RECRUITING
Conditions: Neoplasms|Therapy|Fatigue|Diet Therapy|Time|Survivorship|Fasting, Intermittent
Interventions: BEHAVIORAL: Time-restricted eating|BEHAVIORAL: Healthy lifestyle education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Celecoxib on the Antiplatelet Effect of Aspirin and Clopidogrel in Normal Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: aspirin|DRUG: celecoxib|DRUG: aspirin + celecoxib|DRUG: aspirin + clopidogrel|DRUG: aspirin + clopidogrel + celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of ABBV-3067 Alone and in Combination With ABBV-2222
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: ABBV-3067|DRUG: Placebo ABBV-3067|DRUG: ABBV-2222|DRUG: Placebo ABBV-2222
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treat-and-resect Study of Echo Decorrelation Imaging-controlled Radiofrequency Ablation in Liver Tumors
Status: WITHDRAWN
Conditions: Liver Tumor
Interventions: PROCEDURE: RFA controlled using echo decorrelation imaging|PROCEDURE: RFA controlled using standard manufacturer-specified algorithms
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-Dose Chemotherapy Followed by Total-Body Irradiation and Peripheral Stem Cell Transplantation in Treating Patients With Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: filgrastim|DRUG: cyclophosphamide|DRUG: dexamethasone|DRUG: etoposide|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Analysis of the Immunobiology of Acute Myeloid Leukemia Relapses After Allogeneic Hematopoietic Stem Cell Transplant (HSCT) for the Generation of Guidelines and Personalized Therapeutic Pathways
Status: RECRUITING
Conditions: Acute Myeloid Leukemia, in Relapse
Interventions: OTHER: Observations on Relapsed AML Allogeneic Transplanted patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transcutaneous Electrical Acupoint Stimulation for Postoperative Cognitive Dysfunction
Status: COMPLETED
Conditions: Postoperative Cognitive Dysfunction
Interventions: DEVICE: Transcutaneous electrical acupoint stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Indigo Naturalis in Treating Atopic Dermatitis Topically
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Indigo naturalis ointment|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Individualized Blood Pressure Management During Endovascular Stroke Treatment
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: PROCEDURE: INDIVIDUALIZED BLOOD PRESSURE MANAGEMENT DURING ENDOVASCULAR TREATMENT OF ACUTE ISCHEMIC STROKE UNDER PROCEDURAL SEDATION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of GSK1014802 on Electrical Hyperalgesia and Threshold Tracking in Healthy Subjects
Status: TERMINATED
Conditions: Pain, Neuropathic|Neuropathic Pain
Interventions: DRUG: GSK1014802 low dose|DRUG: Lidocaine|DRUG: GSK1014802 high dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Evaluation of Dasatinib (Sprycel®, NSC #732517) in the Treatment of Persistent or Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Carcinoma
Status: COMPLETED
Conditions: Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma
Interventions: DRUG: Dasatinib|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Combination of Zarnestra With Velcade for Patients With Relapsed Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: PS-341|DRUG: R11577
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-transplant PT/FLU+CY Promotes Unrelated Cord Blood Engraftment in Haplo-cord Setting in Childhood Leukemia
Status: RECRUITING
Conditions: Leukemia|Stem Cell Transplant|Cord Blood
Interventions: PROCEDURE: applying of FLU+CY post-HSCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irinotecan Plus Carmustine in Treating Patients With Recurrent Primary Malignant Glioma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: carmustine|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: SURGX Antimicrobial Gel Versus Povidone-iodine Skin Incision Prep in Total Shoulder Arthroplasty
Status: COMPLETED
Conditions: Surgery|Surgical Site Infection|Cutibacterium Acnes|Prosthetic-joint Infection
Interventions: DRUG: Povidone-Iodine|DEVICE: SURGX Wound Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Feasibility Trial of Avastin (Bevacizumab) in Combination With Concomitant Chemoradiation (Cisplatin and Vinorelbine) in Patients With Locally Advanced Non-Squamous Non-Small Cell Lung Cancer.
Status: COMPLETED
Conditions: Non-Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: bevacizumab [Avastin]|DRUG: cisplatin|DRUG: vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of High-Risk Prostate Cancer Guided by Novel Diagnostic Radio- and Molecular Tracers
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Darolutamide|DRUG: Darolutamide matched placebo|RADIATION: Radiotherapy|DRUG: Zoladex 3.6Mg Implant|DRUG: Zoladex LA|DRUG: Decapeptyl sustained release 22.5 mg|DRUG: Decapeptyl sustained release 11.25 mg|DRUG: Depo-Eligard 45 mg|DRUG: Depo-Eligard 22.5 mg|DRUG: Depo-Eligard 7.5 mg|DRUG: Firmagon 120 MG Injection|DRUG: Firmagon 80 MG Injection|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EyeQue VisionCheck 510(k) Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Refractive Errors|Astigmatism
Interventions: DEVICE: EyeQue VisionCheck|DEVICE: Phoropter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Ablative Fractional Laser-assisted Photodynamic Therapy According to the Laser Density for Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: lidocaine/prilocaine (5%) application|DEVICE: 2940-nm Er:YAG AFL pretreatment|DRUG: MAL application|OTHER: Measurements of the fluorescence intensity|DEVICE: irradiation with red light-emitting diode lamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nutritional Intervention Preconception and During Pregnancy to Maintain Healthy Glucose Metabolism and Offspring Health
Status: COMPLETED
Conditions: Hyperglycemia
Interventions: DIETARY_SUPPLEMENT: Study nutritional drink|DIETARY_SUPPLEMENT: Standard nutritional drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: VX15/2503 and Immunotherapy in Resectable Pancreatic and Colorectal Cancer
Status: COMPLETED
Conditions: Colon Carcinoma Metastatic in the Liver|Colorectal Adenocarcinoma|Pancreatic Adenocarcinoma|Resectable Pancreatic Carcinoma|Stage I Pancreatic Cancer|Stage IA Pancreatic Cancer|Stage IB Pancreatic Cancer|Stage II Pancreatic Cancer|Stage IIA Pancreatic Cancer|Stage IIB Pancreatic Cancer|Stage III Pancreatic Cancer|Stage IV Colorectal Cancer|Stage IVA Colorectal Cancer|Stage IVB Colorectal Cancer
Interventions: BIOLOGICAL: Anti-SEMA4D Monoclonal Antibody VX15/2503|BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Ethyl-Alpha-Guanido-Methyl Ethanoate on Skin Reactions From Glatiramer Acetate Injections
Status: WITHDRAWN
Conditions: Multiple Sclerosis
Interventions: DRUG: AGEE cream|DRUG: 1% Steroid Cream|DRUG: topical placebo cream with no active ingredients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pregabalin in the Prevention of Postoperative Delirium and Pain
Status: COMPLETED
Conditions: Delirium|Pain
Interventions: DRUG: Pregabalin|OTHER: Sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare a New Eye Drop Formulation With Refresh Contacts®
Status: COMPLETED
Conditions: Contact Lens Lubrication
Interventions: DRUG: carboxymethylcellulose based eye drop formula|DRUG: carboxymethylcellulose sodium based eye drop solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MEKTOVI® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma
Status: RECRUITING
Conditions: Adamantinous Craniopharyngioma|Recurrent Adamantinomatous Craniopharyngioma
Interventions: DRUG: Binimetinib Oral Tablet [Mektovi]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Oxygen Target Range on Intermittent Hypoxemia in Preterm Infants
Status: UNKNOWN
Conditions: Intermittent Hypoxemia|Apnea of Prematurity
Interventions: DRUG: Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Customized Corneal Cross-linking vs. Standard Corneal Cross-linking
Status: COMPLETED
Conditions: Keratoconus
Interventions: PROCEDURE: Customized crosslinking|PROCEDURE: Standard crosslinking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ReMindCare App for Patients From First Episode of Psychosis Unit.
Status: UNKNOWN
Conditions: Psychosis|Schizophrenia|Psychotic Disorders|Delirium|Hallucinations|Adherence, Medication|Treatment Side Effects
Interventions: DEVICE: ReMindCare Intervention Group|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Fitness of Patients With Multiple Sclerosis, Effect of Exercise on Fatigue and Depression
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: PROCEDURE: Controlled combined exercise group|PROCEDURE: Conventional rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Advanced Lung Tumor Treated by Osimertinib Plus Anlotinib
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer With EGFR Mutation|Locally Advanced Solid Tumor|Metastatic Cancer|Adenocarcinoma of Lung
Interventions: DRUG: Osimertinib|DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy, Safety and Tolerability of Remibrutinib in Adult Participants With an Allergy to Peanuts
Status: RECRUITING
Conditions: Allergy, Peanut
Interventions: DRUG: remibrutinib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Neurostimulation to Treat Paroxysmal Sympathetic Hyperactivity in Children
Status: RECRUITING
Conditions: Paroxysmal Sympathetic Hyperactivity
Interventions: DEVICE: Percutaneous Electrical Nerve Field Stimulation (PENFS) device application
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation
Status: RECRUITING
Conditions: KRAS G12C Mutant Solid Tumors|Carcinoma, Non-Small-Cell Lung|Carcinoma, Colorectal|Cancer of Lung|Cancer of the Lung|Lung Cancer|Neoplasms, Lung|Neoplasms, Pulmonary|Pulmonary Cancer|Pulmonary Neoplasms
Interventions: DRUG: JDQ443|DRUG: TNO155|BIOLOGICAL: tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Isoflavone in Patients With Watchful Waiting Benign Prostate Hyperplasia
Status: COMPLETED
Conditions: Benign Prostate Hyperplasia
Interventions: DRUG: isoflavones (Soylife 25)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Performance of Flexima®/Softima® Stoma Appliances in Enterostomy Patients
Status: UNKNOWN
Conditions: Enterostomy|Stoma Ileostomy|Stoma Colostomy
Interventions: DEVICE: Flexima®/Softima® stoma bags
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ULtrafiltration-Rate Induced CArdiac Strain (ULRICA) - Study
Status: RECRUITING
Conditions: Fluid Overload|Dialysis; Complications
Interventions: PROCEDURE: Ultrafiltration rate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of the Safety, Blood Levels and Biological Effects of GBT440 in Healthy Subjects and Subjects With Sickle Cell Disease
Status: COMPLETED
Conditions: Healthy Subjects|Sickle Cell Disease
Interventions: DRUG: GBT440|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Contralateral Isokinetic Training on Strength and Reaching Skill
Status: COMPLETED
Conditions: Hemiplegic Cerebral Palsy
Interventions: OTHER: Physical therapy exercises|OTHER: Isokinetic training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Cytarabine in the Treatment of Central Nervous System Resistant or Relapsed Acute Lymphoblastic Leukemia in Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: liposomal cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: D-cycloserine for the Treatment of Chronic, Refractory Low Back Pain
Status: TERMINATED
Conditions: Low Back Pain|Pain
Interventions: DRUG: D-cycloserine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Cell Count, Viability, and Immunogenicity of Discarded Newly Diagnosed Glioblastoma Tissue or Solid Tumor Tissues
Status: RECRUITING
Conditions: Glioblastoma|Malignant Solid Neoplasm
Interventions: PROCEDURE: Biospecimen Collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ultrasound Prescan vs Conventional Landmark-guided Technique in Spinal Anesthesia in Orthopedic Obese Patients
Status: COMPLETED
Conditions: Ultrasonography|Anesthesia, Spinal|Body Mass Index|Obesity
Interventions: DEVICE: Accuro|PROCEDURE: cutaneous landmarks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of the Combination Vorinostat With Lenalidomide, Bortezomib and Dexamethasone for Patients With Newly Diagnosed Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Mother Rehabilitative Aid Education Program on Children With Diplegic Cerebral Palsy
Status: COMPLETED
Conditions: Diplegic Cerebral Palsy
Interventions: OTHER: Mother Rehabilitative Aid Education Program|OTHER: Neuro physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluating The Safety and Effectiveness of The NeoDisc™ Versus ACDF in Subjects With Single-Level Cervical Disc Disease
Status: COMPLETED
Conditions: Cervical Disc Degenerative Disorder
Interventions: DEVICE: NeoDisc|DEVICE: Instrumented Anterior Cervical Discectomy and Fusion (ACDF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/Ib Study of Nivolumab & Veliparib in Patients With Advanced Solid Tumors & Lymphoma
Status: COMPLETED
Conditions: Advanced Solid Neoplasm|Aggressive Non-Hodgkin Lymphoma|Recurrent Solid Neoplasm|Refractory Mantle Cell Lymphoma|T-Cell Non-Hodgkin Lymphoma|Unresectable Solid Neoplasm
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab|OTHER: Pharmacological Study|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Rhodiola Crenulata Intake Improve Oxygen Saturation and Decrease the Incidence of Acute Mountain Sickness
Status: COMPLETED
Conditions: Acute Mountain Sickness|Environmental Illness
Interventions: DRUG: Rhodiola crenulata|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Activating Collaborative CIS Support Via Targeted Provider Mailing
Status: COMPLETED
Conditions: Precancerous Condition
Interventions: OTHER: Usual care mailing intervention|OTHER: CIS support mailing intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of PBT2 in Patients With Early to Mid Stage Huntington Disease
Status: COMPLETED
Conditions: Huntington Disease
Interventions: DRUG: PBT2|DRUG: PBT2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Moderate Sedation for Elective Upper Endoscopy With Balanced Propofol Versus Propofol Alone: a Randomized Clinical Trial
Status: COMPLETED
Conditions: EGD Procedure
Interventions: DRUG: Midazolam + propofol|DRUG: propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: First Time in Humans (FTIH) Study of GSK3368715 in Participants With Solid Tumors and Diffuse Large B-cell Lymphoma (DLBCL)
Status: TERMINATED
Conditions: Neoplasms
Interventions: DRUG: GSK3368715|DRUG: GSK3368715
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remifentanil and Desflurane Inhalational Anesthesia in Bariatric Surgeries
Status: UNKNOWN
Conditions: Anesthesia Emergence
Interventions: DRUG: Normal Saline|DRUG: Remifentanil 0.1 ug/kg|DRUG: Remifentanil 0.2 ug/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Halodine Nasal Antiseptic in Patients With COVID-19
Status: UNKNOWN
Conditions: SARS-CoV-2 Infection
Interventions: DRUG: Povidone-Iodine Solution 1.25% w/w [0.125% available iodine] USP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Influence of Probiotics in a Drinkable Yogurt on Skin Health
Status: COMPLETED
Conditions: Skin Health
Interventions: DIETARY_SUPPLEMENT: no bacterial strains|DIETARY_SUPPLEMENT: One probiotic strain - Lactobacillus paracasei NCC2461|DIETARY_SUPPLEMENT: Two standard yogurt fermenting bacterial strains - Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus|DIETARY_SUPPLEMENT: Vit B2, B3, C and E, Beta Carotene and Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Registry for Vascular Anomalies Associated With Coagulopathy
Status: COMPLETED
Conditions: Multifocal Lymphangioendotheliomatosis With Thrombocytopenia|Cutaneovisceral Angiomatosis With Thrombocytopenia|Vascular Anomaly With Thrombocytopenia|Hemangiomas
Interventions: OTHER: no intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study on Efficacy (Effectiveness), Safety, and Impact on Quality of Life Measures of Dilaudid CR (Controlled Release);, Hydromorphone HCl in Patients With Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: OROS® hydromorphone HCL; Dilaudid CR (controlled release); Dilaudid IR (immediate release) as rescue medicine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Ointment for the Treatment of Plaque-type Psoriasis
Status: COMPLETED
Conditions: Plaque-type Psoriasis
Interventions: DRUG: AN2728 Ointment|DRUG: AN2728 Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CAB-ROR2-ADC Safety and Efficacy Study in Patients With TNBC or Head & Neck Cancer (Ph1) and NSCLC or Melanoma (Ph2)
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer|Triple Negative Breast Cancer|Melanoma|Head and Neck Cancer
Interventions: BIOLOGICAL: CAB-ROR2-ADC|BIOLOGICAL: PD-1 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2/3 Study in Adult and Pediatric Participants With SCD
Status: RECRUITING
Conditions: Sickle Cell Disease
Interventions: DRUG: Osivelotor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Automated Bilingual Computerized Alcohol Screening and Intervention in Latinos (AB-CASI)
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: BEHAVIORAL: Computerized Alcohol Screening|BEHAVIORAL: Brief Negotiated Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Xolair (Omalizumab) in Patients With Chronic Idiopathic Urticaria (CIU) Who Remain Symptomatic With Antihistamine Treatment (H1)
Status: COMPLETED
Conditions: Chronic Idiopathic Urticaria
Interventions: DRUG: omalizumab|DRUG: placebo|DRUG: H1 antihistamines|DRUG: Diphenhydramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin C in Autologous Stem Cell Transplantations
Status: COMPLETED
Conditions: Myeloma Multiple|Lymphoma
Interventions: DRUG: Vitamin C|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation Through the Italian Version of the Teen Online Problem-Solving (TOPS) Program
Status: COMPLETED
Conditions: Neurological Diseases or Conditions
Interventions: DEVICE: Teen On-line Problem Solving
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of a Novel 18F-DTBZ PET Imaging as a Biomarker to Monitor Neurodegeneration of PARK6 and PARK8 Parkinsonism
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: 18F-DTBZ
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intravitreal Dexamethasone Implant for Refractory Diabetic Macular Edema:
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Intravitreal Dexamethasone Implant for refractory Diabetic macular edema:
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Taspoglutide Versus Sitagliptin for the Treatment of Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin.
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: Metformin|DRUG: Placebo (matching sitagliptin)|DRUG: Placebo (matching taspoglutide)|DRUG: Sitagliptin|DRUG: Taspoglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multimodal Treatment Study of Children With Attention Deficit and Hyperactivity Disorder (MTA)
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity|Substance-related Disorders|Dyssocial Behavior
Interventions: BEHAVIORAL: Psychosocial treatment|DRUG: Anti-ADHD medication|BEHAVIORAL: Assessment-and-Referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerance of High Flow Nasal Cannula for Respiratory Distress Syndrom in Late Preterms (34-36 Weeks)
Status: COMPLETED
Conditions: Respiratory Distress Syndrom|High Flow Nasal Cannula
Interventions: DEVICE: High Flow Nasal Cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Propofol TCI Administered by Gastroenterologists During Endoscopy: a Randomized Double Blind Controlled Study
Status: COMPLETED
Conditions: Propofol|Target Controlled Infusion|Moderate Sedation|Gastrointestinal Endoscopy
Interventions: DRUG: Propofol|DRUG: Midazolam|DEVICE: Target Controlled Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: N-3 Fatty Acids as the First-line Antidepressant Therapy: From Biomarkers to Clinical Subtypes
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DIETARY_SUPPLEMENT: Omega-3 fatty acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Left Internal Thoracic Artery Bypass Versus Percutaneous Revascularization in Diabetics
Status: WITHDRAWN
Conditions: Coronary Artery Disease|Diabetes Mellitus
Interventions: PROCEDURE: Minimally Invasive Coronary Bypass|PROCEDURE: Percutenous Coronary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Retreatment With Intratumoral Diffusing Alpha Radiation Emitters
Status: RECRUITING
Conditions: Skin Cancer|Mucosal Neoplasm of Oral Cavity|Soft Tissue Neoplasm
Interventions: DEVICE: Radiation: Diffusing Alpha Radiation Emitters Therapy (DaRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Translating the Diabetes Prevention Program (DPP) Lifestyle Intervention to Rural African-American Communities (HEALTHY Ways)
Status: COMPLETED
Conditions: Overweight
Interventions: BEHAVIORAL: DPP lifestyle intervention-Community Health Coach (CHWs)|BEHAVIORAL: DPP Lifestyle intervention--health professionals/(PHCs)|OTHER: Self Help
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study With a Topical Gel Containing TRIAC and DHEA in Subjects With Skin Atrophy Due to Glucocorticoids
Status: UNKNOWN
Conditions: Skin Atrophy
Interventions: COMBINATION_PRODUCT: DHEA and TRIAC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Extra Virgin Olive Oil Addition in the Diet of Women With Gestational Diabetes Mellitus (OLIDIAG)
Status: COMPLETED
Conditions: Gestational Diabetes
Interventions: DIETARY_SUPPLEMENT: Extra Virgin Olive Oil Addition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Research Study to Investigate How Well Semaglutide Tablets Taken Once Daily Work in East Asian People Who Are Overweight or Living With Obesity
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: DRUG: semaglutide 50 mg|DRUG: placebo (semaglutide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: B Cell Induction in Pediatric Lung Transplantation
Status: COMPLETED
Conditions: Lung Transplant
Interventions: BIOLOGICAL: Rituximab (Rituxan®)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cilengitide and Sunitinib Malate in Treating Patients With Advanced Solid Tumors or Glioblastoma Multiforme
Status: TERMINATED
Conditions: Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Adult Solid Neoplasm|Recurrent Adult Brain Neoplasm
Interventions: DRUG: Cilengitide|OTHER: Clinical Observation|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the PET Imaging Agent [18F]NAV4694 in Subjects With Probable Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: DRUG: [18F]NAV4694
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study in Subjects With PAH and PH Secondary to IPF Using Inhaled GeNOsyl.
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension|Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Inhaled Nitric Oxide|DRUG: Inhaled Nitric Oxide|DRUG: Inhaled Nitric Oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bendamustine Plus Alemtuzumab for Refractory Chronic Lymphocytic Leukemia (CLL)
Status: TERMINATED
Conditions: Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Stage III Chronic Lymphocytic Leukemia|Stage III Small Lymphocytic Lymphoma|Stage IV Chronic Lymphocytic Leukemia|Stage IV Small Lymphocytic Lymphoma
Interventions: DRUG: Bendamustine Hydrochloride|BIOLOGICAL: Alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety, Tolerability & Efficacy in Cystic Fibrosis Patients With Abnormal Glucose Tolerance
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DRUG: PBI4050|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel With or Without Cixutumumab as Second-Line Therapy in Treating Patients With Metastatic Esophageal Cancer or Gastroesophageal Junction Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Esophageal Adenocarcinoma|Metastatic Esophageal Squamous Cell Carcinoma|Metastatic Gastroesophageal Junction Adenocarcinoma|Recurrent Esophageal Adenocarcinoma|Recurrent Esophageal Carcinoma|Recurrent Esophageal Squamous Cell Carcinoma|Recurrent Gastroesophageal Junction Adenocarcinoma|Stage IV Esophageal Cancer AJCC v7
Interventions: BIOLOGICAL: Cixutumumab|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection and Prevention of Anthracycline-Related Cardiac Toxicity With Concurrent Simvastatin
Status: TERMINATED
Conditions: Breast Cancer|Stage I Breast Cancer|Stage II Breast Cancer|Stage III Breast Cancer
Interventions: DRUG: Simvastatin|DRUG: Doxorubicin/cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT