pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study to Find the Appropriate Dose of a New Gadolinium-based Contrast Agent (GBCA) for Adults Undergoing Magnetic Resonance Imaging (MRI) for Known or Highly Suspected Brain and/or Spinal Cord Conditions
Status: COMPLETED
Conditions: Central Nervous System Pathology
Interventions: DRUG: Gadoquatrane (BAY1747846)|DRUG: Gadobutrol (Gadovist/Gadavist)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluate the Efficacy and Safety of Genexol®-PM Compared to Genexol® in Recurrent or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Genexol-PM®|DRUG: Genexol®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Dosages of Dark Chocolate on Arterial Blood Pressure in Cardiovascular High-risk Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: dark chocolate 6 g/day|DIETARY_SUPPLEMENT: dark chocolate 25 g/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial of Lifestyle Interventions to Prevent Diabetes in Women With Previous Gestational Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus|Diabetes, Gestational
Interventions: BEHAVIORAL: Promote and support healthy behaviors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Multicenter Study to Evaluate the ROX Coupler in Subjects With Hypertension
Status: TERMINATED
Conditions: Hypertension|High Blood Pressure
Interventions: DEVICE: ROX Coupler|OTHER: Sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Evinacumab in Patients With Homozygous Familial Hypercholesterolemia
Status: COMPLETED
Conditions: Homozygous Familial Hypercholesterolemia
Interventions: DRUG: evinacumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sildenafil for Early Pulmonary Vascular Disease in Scleroderma
Status: RECRUITING
Conditions: Scleroderma|Mildly Elevated Pulmonary Pressures
Interventions: DRUG: Sildenafil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pessary Post Vaginal Prolapse Repair, for One Month, to Reduce the Recurrence Rate of Prolapse
Status: UNKNOWN
Conditions: Use of Pessary Reduce the Number of Prolapse Recurrence|Uterine Prolapse|Cystocele|Rectocele
Interventions: DEVICE: vaginal pessary
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Nimotuzumab and Nivolumab in Treating Patients With Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: EGFR Gene Mutation|Recurrent Non-Small Cell Lung Carcinoma|Stage IIIA Non-Small Cell Lung Cancer|Stage IIIB Non-Small Cell Lung Cancer|Stage IV Non-Small Cell Lung Cancer
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nimotuzumab|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carboplatin and Gemcitabine Combined With Celecoxib and/or Zileuton in Treating Patients With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: celecoxib|DRUG: gemcitabine hydrochloride|DRUG: zileuton
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comfort Level of Two Abdominal Compression Methods Used to Hold Patients Still While Undergoing Stereotactic Body Radiation Therapy for Lung Tumors
Status: TERMINATED
Conditions: Lung Cancer
Interventions: OTHER: questionnaire administration|PROCEDURE: computed tomography|RADIATION: radiation therapy treatment planning/simulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: 36 vs 48 Wks Peg-Intron Plus Ribavirin for HCV Patients Without Rapid Virologic Response But Without HCV RNA at wk 8
Status: UNKNOWN
Conditions: Hepatitis C Infection
Interventions: DRUG: Pegintron + Riba
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Konjac-mannan in Individuals With Insulin-Resistance Syndrome
Status: COMPLETED
Conditions: Insulin Resistance Syndrome
Interventions: DIETARY_SUPPLEMENT: konjac glucomannan|DIETARY_SUPPLEMENT: wheat bran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Different Nanohybrid Flowable Composite Resin on Shear Bond Strength and Dimensional Changes of Invisalign Attachments After 6 Months of Brushing
Status: ENROLLING_BY_INVITATION
Conditions: Malocclusion
Interventions: DEVICE: GrandioSO Heavy Flow|DEVICE: Filtek Z350XT Flowable
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: High-Dose Atorvastatin for Vascular Wall Protection in Thrombectomy Patients
Status: NOT_YET_RECRUITING
Conditions: Mechanical Thrombectomy|Acute Ischemic Stroke
Interventions: DRUG: Atorvastatin 80mg|DRUG: Atorvastatin 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Brain Stimulation to Treat Chronic Concussive Symptoms
Status: NOT_YET_RECRUITING
Conditions: Post-Concussion Syndrome|Concussion, Brain|Mild Traumatic Brain Injury|Head Injury|Headache|Dizziness|Cognitive Symptom|Dysautonomia|Anxiety|Irritability; Syndrome|Depression|Post-traumatic Stress Disorder
Interventions: DEVICE: Active cTBS|DEVICE: Inactive/Sham cTBS|BEHAVIORAL: Imaginal exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mobile Mindfulness for Alcohol Use and PTSD Among Veterans
Status: ACTIVE_NOT_RECRUITING
Conditions: Alcohol Use Disorder|Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Mobile Mindfulness-Relapse Prevention (mMBRP)|BEHAVIORAL: Exercise/healthy eating mobile app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Propofol and Ketofol on Core Body Temperature in MRI
Status: COMPLETED
Conditions: Children
Interventions: DRUG: propofol|DRUG: Ketamine propofol mixture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Long Acting Insulin Glargine Titration Web Tool (LTHome) vs Enhanced Usual Therapy of Glargine Titration
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: Long-acting insulin glargine titration web tool (LTHome)|OTHER: Diabetes Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Extra Corporeal Circuit Prime on Electrolytes Balance and Clinical Outcome Following Cardiac Surgery
Status: COMPLETED
Conditions: Cardiac Surgery
Interventions: DIAGNOSTIC_TEST: Heart-lung machine primining solution which includes Mannitol|DIAGNOSTIC_TEST: Heart-lung machine primining solution which does not include Mannitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Motivational Interviewing (MI) for African Americans With Peripheral Arterial Disease (PAD)
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: BEHAVIORAL: Motivational Interviewing|BEHAVIORAL: PACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of High vs. Standard Protein Intake in Newborn Extreme Premature
Status: COMPLETED
Conditions: Abnormal Renal Function|Malnutrition
Interventions: DIETARY_SUPPLEMENT: use amine acids parenteral 3.5g|DIETARY_SUPPLEMENT: use amine acids parenteral 4g
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: An Exploratory Study to Investigate the Effect of FE 999302 When Given Together With Follitropin Delta During Controlled Ovarian Stimulation
Status: RECRUITING
Conditions: Fertility
Interventions: DRUG: Follitropin delta|DRUG: FE999302|DRUG: FE999302 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise and Coronary Heart Disease Risk Markers in Male Smokers and Non-Smokers
Status: COMPLETED
Conditions: Cigarette Smoking|Coronary Heart Disease|Cardiovascular Risk Factor|Insulin Resistance|Oxidative Stress|Inflammation
Interventions: BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety Study Evaluating Intravenous Infusions of Tigecycline to Treat Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Tigecycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplemental Oxygen in Pulmonary Embolism (SO-PE)
Status: RECRUITING
Conditions: Pulmonary Embolism|Venous Thromboembolism|Metabolomics|Oxygen Inhalation Therapy
Interventions: DRUG: Oxygen Therapy|DEVICE: Non-rebreather mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Transversus Abdominis Plane Block for Pain Relieve in Children Undergoing Groin Surgery
Status: TERMINATED
Conditions: Postoperative Pain|Reaction; Anesthesia
Interventions: DRUG: Bupivacain/levobupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Motor Imagery Based on Action Observation Treatment on Dysphagia in Wallenberg Syndrome
Status: COMPLETED
Conditions: Lateral Medullary Syndrome|Deglutition Disorders
Interventions: OTHER: conventional dysphagia treatment|OTHER: motor imagery based on action observation treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Manual Therapy for the Treatment of Athletic Pubalgia
Status: RECRUITING
Conditions: Osteitis Pubis
Interventions: OTHER: High force hip Lateral distraction|OTHER: Placebo force hip lateral distraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of the ANS Dysregulation in the Persistence of Fatigue in Rheumatoid Arthritis Patients Treated With Anti-TNF
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DEVICE: VistaO2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety/Efficacy Study of Oral Recombinant Human Lactoferrin in Renal Cell Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Recombinant Human Lactoferrin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of tDCS on Apraxia of Speech in Non-Fluent Primary Progressive Aphasia
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Progressive Aphasia
Interventions: DEVICE: Active tDCS plus Speech-Language Therapy|DEVICE: Sham plus Speech-Language Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of N-acetylcysteine for Thrombotic Events After Allogenic Hematopoietic Stem Cell Transplantation
Status: NOT_YET_RECRUITING
Conditions: Thrombotic Disorder
Interventions: DRUG: N-acetyl-cysteine|DRUG: Busulfan|DRUG: Cytarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparisons of 3-month Versus 6-month Solifenacin Treatment for Female OAB Patients
Status: UNKNOWN
Conditions: Overactive Bladder Syndrome
Interventions: DRUG: Solifenacin for 12 weeks|DRUG: Solifenacin for 24 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA
Status: RECRUITING
Conditions: Glioblastoma|Anaplastic Astrocytoma|Anaplastic Oligoastrocytoma|Glioma|Brain Neoplasm|Brain Cancer|Brain Tumor|Brain Tumor, Recurrent|Brain Neoplasm, Malignant
Interventions: DRUG: Intra-arterial Cetuximab|DRUG: Intra-arterial Mannitol|RADIATION: Hypofractionated re-irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess the Efficacy of CitruSlim® on Body Composition as Well as Metabolic and Hormonal Factors in Overweight and Obese Individuals
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: Citrus flavonone-O-glycosides- LD|DIETARY_SUPPLEMENT: Citrus flavonone-O-glycosides- HD|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: EScitalopram PIndolol ONset of Action
Status: TERMINATED
Conditions: Unipolar Depression
Interventions: DRUG: escitalopram, pindolol|DRUG: escitalopram|DRUG: escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Blood Levels, Drug Interaction and Effects of Repeated Doses of GSK1034702
Status: COMPLETED
Conditions: Cognitive Disorders
Interventions: DRUG: GSK1043702|DRUG: Dextromethorphan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Palonosetron Associated to Aprepitant in Prophylaxis of PONV
Status: UNKNOWN
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Aprepitant|DRUG: Placebo|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess Effect of Oral Venetoclax Tablet in Combination With Oral Ibrutinib Capsule on Best Overall Response of Complete Response in Adult Japanese Participants With Relapsed/Refractory Mantle Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Mantle Cell Lymphoma (MCL)
Interventions: DRUG: Ibrutinib|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BIO REsponse Adapted Combination Therapy Pilot Study
Status: UNKNOWN
Conditions: Peripheral Arterial Disease
Interventions: DIAGNOSTIC_TEST: Duplex Ultrasound (DUS)|DIAGNOSTIC_TEST: IVUS with Intraarterial pressure measurement (IAP) if needed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Interleukin-2 in Triple Negative Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Human Interleukin-2 (IL-2) (Proleukin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Test the Safety of CDNF by Brain Infusion in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Movement Disorders|Neurodegenerative Diseases|Nervous System Diseases|Brain Diseases
Interventions: DRUG: Cerebral Dopamine Neurotrophic Factor|DEVICE: Renishaw Drug Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Anastrozole, Letrozole, or Exemestane With or Without Tamoxifen in Treating Postmenopausal Women With Hormone-Responsive Breast Cancer That Has Been Completely Removed By Surgery
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: anastrozole|DRUG: exemestane|DRUG: letrozole|DRUG: tamoxifen citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab + Alpelisib +/- Fulvestrant vs Trastuzumab + CT in Patients With PIK3CA Mutated Previously Treated HER2+ Advanced BrEasT Cancer (ALPHABET)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Breast Cancer
Interventions: BIOLOGICAL: Trastuzumab|DRUG: Alpelisib|DRUG: Fulvestrant|DRUG: Vinorelbine|DRUG: Capecitabine|DRUG: Eribulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Growth of Infants Fed an Elemental Medical Food
Status: COMPLETED
Conditions: Healthy Infants
Interventions: OTHER: Control Study Formula|OTHER: Experimental Study Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VNP40101M in Treating Patients With Relapsed or Refractory Leukemia or Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: DRUG: laromustine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intelligent Oxygen Therapy During Activities of Daily Living
Status: COMPLETED
Conditions: Hypoxia|COPD|Hyperoxia
Interventions: DEVICE: Intelligent oxygen therapy (an auto-titrating oxygen system)|DEVICE: Long-term oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Accelerated Radiation Therapy After Surgery in Treating Patients With Breast Cancer
Status: COMPLETED
Conditions: Inflammatory Breast Cancer|Invasive Ductal Breast Carcinoma|Invasive Lobular Breast Carcinoma|Mucinous Ductal Breast Carcinoma|Papillary Ductal Breast Carcinoma|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Tubular Ductal Breast Carcinoma
Interventions: RADIATION: External beam radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Safety and Tolerability of PDNO Infusion in Patients With Pulmonary Hypertension After Cardiopulmonary Bypass Surgery
Status: RECRUITING
Conditions: Pulmonary Hypertension
Interventions: DRUG: PDNO|DRUG: Sodium chloride (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Safety Study of Telaprevir and Sofosbuvir in Chronic Hepatitis C Genotype 1
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Telaprevir and Sofosbuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy and Safety of Rituximab in Patients With Progressive Interstitial Lung Disease (ILD) With Inflammatory Component: a Multicentre Double-blind Placebo-controlled Randomized Trial
Status: RECRUITING
Conditions: Lung Diseases
Interventions: DRUG: Rituximab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-finding Study of Weekly Paclitaxel and Cisplatin in FIGO IB2 and Bulky IIA Cervical Cancer
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: DRUG: Phyxol(Paclitaxel)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Trial to Compare Different Analgesics in Combination With Low Dose Aspirin to Study Their Bleeding Properties and Their Effects on the Stomach
Status: COMPLETED
Conditions: Analgesics
Interventions: DRUG: aspirin, acetaminophen, ibuprofen, naproxen, celecoxib, rofecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Assessing Safety, Hospitalization and Efficacy of rNAPc2 in COVID-19
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: rNAPc2|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Acceptance and Preference Among Screening Modalities for Detection of Barrett's Esophagus
Status: COMPLETED
Conditions: Barrett Esophagus|GERD
Interventions: DEVICE: Cytosponge|DEVICE: Transnasal Endoscopy (TNE)|DEVICE: Esophagogastroduodenoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Incorporating Sprouted and Non-sprouted Chickpea Flour in Pasta Products Analyzed in Vivo Flow-mediated Dilation
Status: COMPLETED
Conditions: Endothelial Dysfunction
Interventions: OTHER: Experimental: Sprouted Chickpea Flour|OTHER: Control: Semolina Flour
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transversus Abdominis Plane Block After Robot-assisted Laparocopic Hysterectomy
Status: TERMINATED
Conditions: Hysterectomy
Interventions: PROCEDURE: TAP block|PROCEDURE: Placebo TAP block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Neurological Effects of Adding Raltegravir to HAART Regimen in Patients With HIV
Status: TERMINATED
Conditions: Human Immunodeficiency Virus (HIV)|HIV Associated Neurocognitive Disorders (HAND)
Interventions: DRUG: Raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bendamustine and Rituximab Combination Therapy for Cold Agglutinin Disease
Status: COMPLETED
Conditions: Cold Agglutinin Disease|Autoimmune Hemolytic Anemia
Interventions: DRUG: Bendamustine, Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Mortality of a Loading Dose of Colistin in Critical Ill Patients
Status: UNKNOWN
Conditions: Gram Negative Bacterial Infections
Interventions: DRUG: colistin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 6 and 17 Years With Moderate to Severe Plaque Psoriasis Treated With Subcutaneous (SC) Injection of Risankizumab Who Have Completed Participation in Study M19-977
Status: ENROLLING_BY_INVITATION
Conditions: Psoriasis
Interventions: DRUG: Risankizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Infectious Outcomes of Povidone-iodine Rectal Cleansing Plus Formalin Disinfection of Needle During Prostate Biopsy
Status: COMPLETED
Conditions: Prostate Cancer|Prostatic Neoplasms|Prostate Biopsy|Prostatitis
Interventions: OTHER: Intrarectal povidone-iodine cleansing plus formalin disinfection of needle tip during transrectal ultrasound guided prostate biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Placebo Controlled Study to Assess Efficacy and Safety of Certolizumab Pegol in the Treatment of Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Certolizumab pegol (CDP870)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Acetaminophen's Efficacy For Post-operative Pain
Status: COMPLETED
Conditions: Tonsillitis|Airway Obstruction|Difficulty Swallowing
Interventions: DRUG: IV acetaminophen|DRUG: PO acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Early Access Program of Telaprevir With Peginterferon and Ribavirin in Chronic Hepatitis C Subjects
Status: NO_LONGER_AVAILABLE
Conditions: Hepatitis C
Interventions: DRUG: Telaprevir + peginterferon alfa + ribavirin|DRUG: peginterferon alfa + ribavirin|DRUG: peginterferon alfa + ribavirin
Study Type: EXPANDED_ACCESS
Clinical trial: Efficacy and Safety of Ranibizumab (Intravitreal Injections) Versus Laser Treatment in Patients With Visual Impairment Due to Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema|Visual Impairment
Interventions: DRUG: RFB002|PROCEDURE: Laser photocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Compare the Efficacy, Safety, Pharmacokinetics and Immunogenicity of HD204 to Avastin® in Advanced Non-squamous Non-small Cell Lung Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer|Non-small Cell Lung Cancer
Interventions: DRUG: Bevacizumab|DRUG: HD204|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: A Pilot Study
Status: COMPLETED
Conditions: Hypertrophic Cardiomyopathy
Interventions: PROCEDURE: trans-right ventricular alcohol septal ablation (TRVASA)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Vildagliptin Versus Glimepiride in Type 2 Diabetic Patients
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: Vildagliptin 50 MG|DRUG: Glimepiride 3 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biocellular-Cellular Regenerative Treatment Scaring Alopecia and Alopecia Areata
Status: RECRUITING
Conditions: Alopecia Areata|Scarring Alopecia
Interventions: PROCEDURE: tSVF by lipoaspiration|PROCEDURE: PRP Concentration|PROCEDURE: Emulsification tSVF|PROCEDURE: cSVF isolation and concentration|PROCEDURE: cSVF in Normal Saline IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radioimmunoimaging of Light Chain (AL) Amyloidosis
Status: COMPLETED
Conditions: AL Amyloidosis
Interventions: BIOLOGICAL: Single infusion of 124I-labeled anti-amyloid mAb 11-1F4: 2 mCi (1 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prospective Pilot Study on Metabolism and Weight Changes in Topiramate-Treated Epilepsy Patients
Status: COMPLETED
Conditions: Epilepsy|Epilepsies, Partial|Epilepsy, Generalized|Seizures
Interventions: DRUG: topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DRP-104 (Glutamine Antagonist) in Combination With Durvalumab in Patients With Advanced Stage Fibrolamellar Carcinoma (FLC)
Status: RECRUITING
Conditions: Fibrolamellar Hepatocellular Carcinoma
Interventions: DRUG: Durvalumab|DRUG: DRP-104
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Recanalization After Intravenous Thrombolysis With Tenecteplase Versus Alteplase in Distal Vessel Occlusion Strokes
Status: RECRUITING
Conditions: Acute Distal Vessel Occlusion Stroke
Interventions: DRUG: Alteplase (0.9mg/kg)|DRUG: Tenecteplase (0.25mg/kg)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pregnancy Intervention With a Closed-Loop System (PICLS) Study
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Pregnancy in Diabetes
Interventions: DEVICE: Hybrid closed-loop therapy|DEVICE: Sensor-augmented pump therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An RCT of Bariatric Surgery vs a Community Weight Loss Programme for the Sustained Treatment of IIH
Status: UNKNOWN
Conditions: Idiopathic Intracranial Hypertension
Interventions: PROCEDURE: Bariatric surgery|BEHAVIORAL: Dietetic intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of Beta-3 Adrenergic Receptor Agonists on Oxidative Stress and Signalling Pathways Implicated in Remodelling of the Uteroplacental Space: Experimental in Vitro Approach on Myometrial Tissue Explants
Status: COMPLETED
Conditions: Pregnancy
Interventions: OTHER: myometrium biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: PlainLanguageRx: Improving Medication Labels to Reduce Health Disparities
Status: COMPLETED
Conditions: Health Behavior|Medication Adherence
Interventions: BEHAVIORAL: PictureRx medication label
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Assess the Safety and Efficacy Of Tafamidis In Chinese Participants With Transthyretin Amyloid Cardiomyopathy (ATTR-CM)
Status: COMPLETED
Conditions: Transthyretin Amyloid Cardiomyopathy
Interventions: DRUG: Tafamidis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The MONACO Cell Therapy Study: Monocytes as an Anti-fibrotic Treatment After COVID-19
Status: UNKNOWN
Conditions: Pulmonary Fibrosis|Interstitial Lung Disease|Covid19
Interventions: BIOLOGICAL: MON002
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ivonescimab Combined With HAIC for the Treatment of Unresectable Hepatocellular Carcinoma（uHCC）.
Status: RECRUITING
Conditions: Hepatocellular Carcinoma Non-resectable|Hepatocellular Carcinoma
Interventions: DRUG: Ivonescimab（AK112，a PD-1/VEGF bispecific antibody）
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Imatinib With Chemotherapy as Induction in Elderly Patients With Philadelphia Positive Acute Lymphoblastic Leukemia (ALL)
Status: UNKNOWN
Conditions: Philadelphia Positive Acute Lymphoblastic Leukemia|Lymphoid Blastic Phase of Chronic Myeloid Leukemia
Interventions: DRUG: imatinib|DRUG: vincristine|DRUG: cyclophosphamide|DRUG: cytosine arabinoside|DRUG: dexamethasone|DRUG: idarubicin|DRUG: methotrexate (intrathecal)|DRUG: AraC (intrathecal)|DRUG: dexamethasone (intrathecal)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Soft Tissue Trimmer in Cases of Gingival Hyperplasia.
Status: COMPLETED
Conditions: Pain, Postoperative|Wound Heal|Gingival Hyperplasia
Interventions: PROCEDURE: Excision of gingival hyperplasia using "Soft tissue trimmer ".|PROCEDURE: Excision of gingival hyperplasia using the conventional scalpel technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Learning Effect of Applying Diversified Teaching in Emergency Injury Classification -Taking the Emergency Nurse of a Regional Hospital in Yunlin County as an Example
Status: ENROLLING_BY_INVITATION
Conditions: Triage
Interventions: BEHAVIORAL: Diversified teaching
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Postoperative Patient Controlled Epidural Analgesia After Total Knee Arthroplasty With 2ug/ml Fentanyl Combine With 0.2% Ropivacaine or 0.2% Levobupivcaine
Status: UNKNOWN
Conditions: Arthroplasty, Replacement, Knee|Patient-controlled Analgesia
Interventions: DRUG: Levobupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Combination of Selinexor (KPT-330), Ixazomib, and Dexamethasone in Patients With Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma|Relapsed and/or Refractory Multiple Myeloma
Interventions: DRUG: Selinexor|DRUG: Ixazomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nurse Coach-Led Early Palliative Care for Older Adults With COPD and Their Care Partners: The Project EPIC Pilot RCT
Status: RECRUITING
Conditions: COPD
Interventions: BEHAVIORAL: EPIC|OTHER: Usual COPD Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pilot Feasibility Study of Psychosocial Support to Improve Well-being of Adults in Humanitarian Crises in Nepal
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Group problem management plus|BEHAVIORAL: Enhanced treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-fibrinolytic and Anti-inflammatory Effects of Local Infiltration of Tranexamic Acid in Patients With Calcaneal Fractures
Status: COMPLETED
Conditions: Tranexamic Acid|Fibrinolysis|Inflammatory|Fracture
Interventions: DRUG: Tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Baclofen for Treating Anxiety and Alcoholism
Status: COMPLETED
Conditions: Alcoholism|Alcohol Dependence|Alcohol Drinking Related Problems|Alcohol Drinking|Anxiety Disorder
Interventions: DRUG: Baclofen|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study Evaluating Fosfomycin/Tobramycin for Inhalation in Cystic Fibrosis Patients With Pseudomonas Aeruginosa Lung Infection
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: FTI, AZLI|DRUG: Placebo, AZLI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LFF269 Compared to Placebo After Treatment in Subjects With Essential Hypertension
Status: TERMINATED
Conditions: Hypertension
Interventions: DRUG: LFF269|DRUG: Eplerenone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stuttering and Anxiety
Status: COMPLETED
Conditions: Stuttering, Childhood|Anxiety Disorders
Interventions: DIAGNOSTIC_TEST: Stuttering severity instrument-3|DIAGNOSTIC_TEST: Child Behavior Checklist for age 4-18
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Robotic Lobectomy vs. Thoracoscopic Lobectomy for Early Stage Lung Cancer: RCT
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer|Thoracic Surgery
Interventions: PROCEDURE: Video-assisted thoracoscopic surgery|PROCEDURE: Robotic thoracic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Open-labeled Study for Comparing Methods of Using Imrecoxib to Treat AS
Status: UNKNOWN
Conditions: Ankylosing Spondylitis|Therapeutic Agent Toxicity
Interventions: PROCEDURE: intermittent treatment|PROCEDURE: continuous treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Legume Consumption on Adiponectin and Inflammatory Markers Among Adults
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: nutritional intervention|OTHER: life style intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Trial to Evaluate and Assess the Effect of Comprehensive Pre-ESKD Education on Home Dialysis Use in Veterans
Status: RECRUITING
Conditions: Chronic Kidney Disease|End Stage Renal Disease|Hemodialysis|Peritoneal Dialysis
Interventions: OTHER: Comprehensive Pre-ESRD Patient Education (CPE)|OTHER: Provision of the freely available resources for Kidney Disease Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Aerosol Inhalation and Intravenous Glucocorticoid in the Treatment of Severe AECOPD
Status: ENROLLING_BY_INVITATION
Conditions: Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Interventions: DRUG: aerosol inhalation of glucocorticoids|DRUG: intravenous injection of glucocorticoids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RSV F Dose-Ranging Study in Women
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: Low dose RSV F Antigen|BIOLOGICAL: High dose RSV F Antigen|BIOLOGICAL: Dose 1 of Aluminum Adjuvant|BIOLOGICAL: Dose 2 of Aluminum Adjuvant|BIOLOGICAL: Dose 3 of Aluminum Adjuvant|BIOLOGICAL: Dose 4 of Aluminum Adjuvant|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Skeletal Anchored Versus Incisal Capped Twin Block Appliance in Class II Malocclusion
Status: COMPLETED
Conditions: Class II Malocclusion
Interventions: DEVICE: skeletal anchored twin block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Plus Albumin-bound Paclitaxel In Patients With Advanced Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Albumin-bound paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Epicutaneous Immunotherapy for the Treatment of Peanut Allergy
Status: COMPLETED
Conditions: Peanut Allergy
Interventions: BIOLOGICAL: Whole peanut extract|BIOLOGICAL: Placebo formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Returning Research Results That Indicate Risk of Alzheimer Disease Dementia to Healthy Participants in Longitudinal Studies
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer Disease|Dementia of Alzheimer Type
Interventions: OTHER: Arm A , Arm B, Arm C, & Arm D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation and Validation of a Multimodal Brain Function Biomarker With NPC
Status: COMPLETED
Conditions: Brain Injuries|Concussion, Mild|Concussion, Brain|Near Point Convergence|Concussion, Intermediate
Interventions: DEVICE: BrainScope Ahead 300iP-O|DIAGNOSTIC_TEST: SCAT5|DIAGNOSTIC_TEST: Near Point Convergence
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination of CAR-DC Vaccine and ICIs in Malignant Tumors
Status: RECRUITING
Conditions: Solid Tumor, Adult|Lymphoma|EphA2 Overexpression|TP53 R273H|TP53 R175H|TP53 R248Q|TP53 R249S
Interventions: BIOLOGICAL: TP53-EphA-2-CAR-DC|DRUG: Abraxane|DRUG: Cyclophosphamide|DRUG: anti-PD-1 antibody|DRUG: Anti-CTLA4 Monoclonal Antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRI-guided Bone Marrow Biopsies of Prostate Cancer Patients
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Bone Marrow Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacies of Bismuth-amoxicillin-vonoprazan Triple Therapy, Vonoprazan-amoxicillin Dual Therapy and Proton Pump Inhibitor-based Standard Triple Therapy for Hp Eradication
Status: RECRUITING
Conditions: Helicobacter Pylori Eradication
Interventions: DRUG: vonoprazan, amoxicillin, tripotassium dicitrate bismuthate|DRUG: vonoprazan, amoxicillin|DRUG: rabeprazole, amoxicillin, clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Islatravir (MK-8591) in Trans and Gender Diverse Participants (MK-8591-035)
Status: WITHDRAWN
Conditions: Human Immunodeficiency Virus (HIV) Infections
Interventions: DRUG: Islatravir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Energy Flux and Fat Oxidation Using Low and High Glycaemic Index Foods
Status: COMPLETED
Conditions: Type 2 Diabetes|Obesity|PreDiabetes
Interventions: OTHER: low glycaemic index intervention|OTHER: high glycaemic index intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Thero2-01S22 in HER2-positive Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: HER2-positive Breast Cancer
Interventions: DRUG: Thero2-01S22|DRUG: Placebo|DRUG: Thero2-01S22|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The PRECISE Trial: Study of IL13-PE38QQR Compared to GLIADEL Wafer in Patients With Recurrent Glioblastoma Multiforme
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: IL13-PE38QQR|PROCEDURE: surgery and catheter placement (2 procedures)|DRUG: prolifespan 20 with carmustine implant (GLIADEL® Wafer)|PROCEDURE: surgery and wafer placement (1 procedure)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UPMC OPTIMISE-C19 Trial, a COVID-19 Study
Status: TERMINATED
Conditions: Covid19
Interventions: BIOLOGICAL: Lilly Bamlanivimab|BIOLOGICAL: Regeneron Casirivimab + Imdevimab|BIOLOGICAL: Lilly Bamlanivimab + Etesevimab|BIOLOGICAL: Sotrovimab|BIOLOGICAL: Bebtelovimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Study Evaluating the Proper Surgical Safety Margin for Early Stage Oral Tongue Cancers
Status: RECRUITING
Conditions: Tongue Cancer|Tongue Cancer TNM Staging Primary Tumor (T) T1|Tongue Cancer TNM Staging Primary Tumor (T) T2|Surgery|Resection Margin|Squamous Cell Carcinoma
Interventions: PROCEDURE: 1.5 cm surgical safety margin for cT1-2N0 oral tongue cancers|PROCEDURE: 1.0 cm surgical safety margin for cT1-2N0 oral tongue cancers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Silver Diamine Fluoride (SDF) on Bacteria Involved in Root or Cervical Carious Lesions
Status: COMPLETED
Conditions: Caries
Interventions: DEVICE: Silver Diamine Fluoride (SDF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT