pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study to Assess the Effect of AZD9291 on the Blood Levels of Simvastatin in Patients With EGFRm+ NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: PROCEDURE: Pharmacokinetic sampling - AZD9291|DRUG: Simvastatin|DRUG: AZD9291 tablet dosing|PROCEDURE: Pharmacokinetic sampling - simvastatin|PROCEDURE: Pharmacokinetic sampling - AZ5140 and AZ7550
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Intubation Via Video Laryngeal Mask Airways (VLMAs) Versus Video Laryngoscopy
Status: WITHDRAWN
Conditions: Laryngeal Mask Airways|Airway Management|Supraglottic Airways|Video-assisted
Interventions: DEVICE: Safe VLM and airway management|PROCEDURE: Endotracheal intubation using video laryngoscope|DEVICE: SaCo VLM and airway management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: LEO 90105 Ointment in Japanese Subjects With Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: LEO 90105 = calcipotriol + betamethasone dipropionate|DRUG: Dovonex® = calcipotriol|DRUG: Rinderon® - DP = betamethasone dipropionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Autologous Blood Injection in Temporomandibular Joint Dislocation
Status: RECRUITING
Conditions: Temporomandibular Joint Dislocation
Interventions: PROCEDURE: ultrasound guided autologous blood injection|PROCEDURE: non guided autologous blood injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GO2 PEEP Study: Bidirectional Oxygenation Valve in Postoperative Atelectasis
Status: COMPLETED
Conditions: Postoperative Atelectasis
Interventions: DEVICE: Incentive spirometer|DEVICE: GO2 Mouthpiece
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Repetitive Transcranial Magnetic Stimulation for the Treatment of Negative Symptoms in Schizophrenia Patients.
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Tremelimumab in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Urothelial Bladder Cancer|Triple-negative Breast Cancer|Pancreatic Ductal Adenocarcinoma
Interventions: BIOLOGICAL: Tremelimumab monotherapy|BIOLOGICAL: MEDI4736 monotherapy|BIOLOGICAL: MEDI4736 + tremelimumab combination therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reality-monitoring & Stress
Status: RECRUITING
Conditions: Healthy Participants
Interventions: PROCEDURE: Acute Maastricht Stress Test (MAST), active condition.|PROCEDURE: Acute Maastricht Stress Test (MAST), placebo condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intermittent Hypoxia and Caffeine in Infants Born Preterm
Status: COMPLETED
Conditions: Intermittent Hypoxia
Interventions: DRUG: Caffeine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protein Requirements Amongst Male Masters-Level Athletes Following a Cycling Exercise Bout as Determined by the Indicator Amino Acid Oxidation Technique
Status: NOT_YET_RECRUITING
Conditions: Healthy|Increased Metabolic Requirements|Dietary Reference Intakes
Interventions: DIETARY_SUPPLEMENT: Amino Acid Intake
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bovine Lactoferrin in Reducing Taste Disturbances in Patients With Colorectal Cancer Receiving Oxaliplatin-Based Chemotherapy
Status: COMPLETED
Conditions: Colorectal Cancer|Dysgeusia|Oral Complications of Chemotherapy
Interventions: OTHER: questionnaire administration|PROCEDURE: quality-of-life assessment|OTHER: laboratory biomarker analysis|DIETARY_SUPPLEMENT: bovine lactoferrin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rh-PDGF vs EMD for Treatment of Intra-bony Defects
Status: RECRUITING
Conditions: Intrabony Periodontal Defect
Interventions: BIOLOGICAL: growth factors to help in regeneration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study to Evaluate the Port Delivery System With Ranibizumab Compared With Monthly Ranibizumab Injections in Participants With Wet Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Neovascular Age-Related Macular Degeneration
Interventions: DRUG: PDS Implant filled with 100 mg/mL Ranibizumab|DRUG: Intravitreal Injections of 10 mg/mL Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: XIENCE V® USA Dual Antiplatelet Therapy (DAPT) Cohort
Status: COMPLETED
Conditions: Chronic Total Occlusion of Coronary Artery|Vascular Disease|Myocardial Ischemia|Coronary Artery Stenosis|Coronary Disease|Coronary Artery Disease|Coronary Restenosis
Interventions: DRUG: placebo + aspirin|DRUG: clopidogrel + aspirin OR prasugrel + aspirin|DEVICE: XIENCE V Everolimus Eluting Coronary Stent System (XIENCE V EECSS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cortico-cortical Stimulation and Robot-assisted Therapy for Upper Limb Recovery After Stroke (CCS&RAT)
Status: RECRUITING
Conditions: Stroke|Stroke, Ischemic
Interventions: DEVICE: Cortico-cortical stimulation plus robot-assisted therapy|DEVICE: Sham cortico-cortical stimulation plus robot-assisted therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Conservative Versus Liberal Red Cell Transfusion in Myocardial Infarction Trial: The CRIT Pilot
Status: COMPLETED
Conditions: Myocardial Infarction|Anemia
Interventions: PROCEDURE: Packed Red Blood Cell Transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Safety and Efficacy for the Relieva Stratus With Elution of Triamcinolone Acetonide
Status: COMPLETED
Conditions: Sinusitis
Interventions: DEVICE: Stratus Microflow Ethmoid Spacer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Insulin Regimens and Postprandial Coagulation Activation
Status: COMPLETED
Conditions: Type 2 Diabetes|Cardiovascular Risk|Hemostasis|Inflammation|Endothelial Function
Interventions: DIETARY_SUPPLEMENT: Standardised meals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-Dose Naltrexone and Acetaminophen Combination and Its Components in the Acute Treatment of Migraine
Status: COMPLETED
Conditions: Migraine With or Without Aura
Interventions: DRUG: Naltrexone and Acetaminophen|DRUG: Naltrexone and Acetaminophen-High Dose|DRUG: Naltrexone Alone (regular dose)|DRUG: Acetaminophen Alone|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Dapagliflozin as Add-on Therapy on Glycemic Status and Quality of Life in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Diabetic Nephropathy Type 2
Interventions: DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Taribavirin Phase 2 Dose Finding Study for the Treatment of Hepatitis C Virus (HCV)
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Taribavirin|DRUG: Taribavirin|DRUG: Taribavirin|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BBI608 in Combination With Temozolomide in Adult Patients With Recurrent or Progressed Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: BBI608|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carotid Artery Stenting With Cilostazol Addition for Restenosis
Status: COMPLETED
Conditions: In-stent Restenosis After Carotid Artery Stenting
Interventions: DRUG: Cilostazol or Non-Cilostazol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GON-injection for a Sooner and Better Treatment of Cluster Headache
Status: COMPLETED
Conditions: Cluster Headache, Episodic|Greater Occipital Nerve Injection
Interventions: DRUG: Methylprednisolone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-hospital Care With Intra-Nasal Ketamine for Transport (PRECINKT): A Pilot Study
Status: COMPLETED
Conditions: Pain|Traumatic Limb Injury
Interventions: DRUG: Intranasal Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Rucaparib Versus Physician's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Castration Resistant Prostate Cancer
Interventions: DRUG: Rucaparib|DRUG: Abiraterone acetate or Enzalutamide or Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Anatomic Deformities on the Clinical Efficacy in the Patients With Patellar Dislocation
Status: RECRUITING
Conditions: Patellar Dislocation|Anatomic Abnormality|Trochlear Dysplasia|Femoral Anteversion|Treatment|Sport Injury
Interventions: OTHER: Collect the clinical data
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rotational Thromboelastometry (ROTEM™) Guided Transfusion for Elective Procedures in Patients With Cirrhosis (REduCe): An Open Label Randomized Controlled Trial.
Status: RECRUITING
Conditions: Cirrhosis, Liver
Interventions: DIAGNOSTIC_TEST: ROTEM|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: ElderTree Via a Voice Activated Device for Managing Chronic Health Conditions (NHLBI)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Conditions, Multiple
Interventions: BEHAVIORAL: ET-Text (Laptop)|BEHAVIORAL: ET-Voice (Smart System)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Proof of Concept Study With 0.5% Roflumilast Cream in Patients With Mild to Moderate Plaque Psoriasis
Status: WITHDRAWN
Conditions: Plaque Psoriasis
Interventions: DRUG: Roflumilast cream|DRUG: Placebo cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Improves Recovery After Cranial Aneurysm Surgery
Status: COMPLETED
Conditions: Aneurysm Cerebral
Interventions: DRUG: Intravenous dexmedetomidine|DRUG: nasal dexmedetomidine|DRUG: intravenous saline|DRUG: nasal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Shock Wave Therapy for Lower Limb Lymphedema
Status: RECRUITING
Conditions: Lymphedema, Lower Limb
Interventions: DEVICE: Extracorporeal shock wave therapy by radial device|DEVICE: Placebo extracorporeal shock wave therapy by radial device|OTHER: DLT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SOP Toolkit in Diverse Practices Implemented & Tested With RE-AIM
Status: COMPLETED
Conditions: Adult Influenza Vaccinations|Adult PPSV Vaccinations|Adult Tdap/Td Vaccinations
Interventions: BEHAVIORAL: Pillar 1: Convenient Vaccination Services|BEHAVIORAL: Pillar 2: Patient notification|BEHAVIORAL: Pillar 3: Enhanced Office Systems|BEHAVIORAL: Pillar 4: Motivation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Erector Spinae Versus Paravertebral Nerve Blocks for Breast Surgery
Status: COMPLETED
Conditions: Breast Surgery
Interventions: DRUG: Erector Spinae (single injection)|DRUG: Paravertebral (single injection)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of N-acetyl Cysteine and Zinc in Management of Head and Neck Cancer Radiotherapy Induced Oral Mucositis
Status: RECRUITING
Conditions: Radiation-Induced Mucositis
Interventions: DRUG: N-acetyl cysteine|DRUG: Zinc sulfate|DRUG: saline mouth wash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Aspirin, Hemodilution and Desmopressin on Platelet Dysfunction
Status: COMPLETED
Conditions: Platelet Dysfunction|Hemodilution|Mild Hypothermia|NSAID|Desmopressin
Interventions: DRUG: Aspirin, desmopressin|DRUG: Placebo, desmopressin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a Novel Subcutaneous Depot Formulation of Buprenorphine
Status: COMPLETED
Conditions: Opioid-use Disorder
Interventions: DRUG: INDV-6200|DRUG: Placebo|DRUG: SL Buprenorphine|DRUG: Nalorex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of DracoBelle Nu in Skin Health After Oral Intake
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Dietary supplementation with placebo.|DIETARY_SUPPLEMENT: Dietary supplementation with DracoBelleTM Nu.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Evolocumab Added to Moderate-Intensity Statin Therapy on LDL-C Lowering and Cardiovascular Adverse Events in Patients With Acute Coronary Syndrome
Status: UNKNOWN
Conditions: Acute Coronary Syndrome|Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor
Interventions: DRUG: Evolocumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Male Subjects to Investigate the Effect of Famotidine and Efavirenz on the Way the Body Takes up, Distributes, and Gets Rid of Daridorexant.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Daridorexant|DRUG: Famotidine|DRUG: Efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Lavender Aromatherapy to Decrease Anxiety/Pain Perception During Office Hysteroscopy
Status: NOT_YET_RECRUITING
Conditions: Anxiety|Pain, Procedural
Interventions: DRUG: Lavandula angustifolia, Aura Cacia|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Randomized Comparison of DCB for the Treatment of Superficial Femoral and Popliteal Peripheral Artery Disease
Status: COMPLETED
Conditions: Angioplasty, Balloon|Catheterization, Peripheral|Popliteal Artery|Femoral Artery
Interventions: DEVICE: IN.PACT drug coated balloon|DEVICE: Lutonix drug coated balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential Vaccination of Poliomyelitis Vaccine (Vero Cells), Inactivated, Sabin Strains From Different Manufacturers
Status: NOT_YET_RECRUITING
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: sIPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Tumor Treating Fields (TTFields, 150 kHz) Concomitant With Best Standard of Care for the Treatment of Hospitalized COVID-19 Patients and Continued Treatment Following Discharge
Status: COMPLETED
Conditions: COVID-19
Interventions: DEVICE: NovoTTF-100L
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-Frequency REpetitive TRanscranial Magnetic Stimulation in ACute Ischemic StrokE Within 48 Hours
Status: NOT_YET_RECRUITING
Conditions: Stroke, Acute|Stroke, Ischemic
Interventions: DEVICE: LF-rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Purpose of This Study is to Evaluate the Spirometric Effect (Trough FEV1) of Umeclidinium/Vilanterol 62.5/25 mcg Once Daily Compared With Tiotriopium 18 mcg Once Daily Over a 24-week Treatment Period in Subjects With COPD
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Umeclidinium/Vilanterol 62.5/25 mcg|DRUG: Tiotropium 18 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Krill Oil on Intestinal Integrity Markers in Elite Rowers.
Status: NOT_YET_RECRUITING
Conditions: Endothelial Dysfunction
Interventions: DIETARY_SUPPLEMENT: THYROX (Atlantic krill oil|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Expanded Access of Fostamatinib in Patients With Persistent or Chronic Relapsing/Refractory ITP
Status: NO_LONGER_AVAILABLE
Conditions: Immune Thrombocytopenic Purpura
Interventions: DRUG: Fostamatinib disodium 100 mg|DRUG: Fostamatinib disodium 150 mg
Study Type: EXPANDED_ACCESS
Clinical trial: Continuous Lenalidomide Therapy Versus Observation Following Induction Without Lenalidomide, Pomalidomide or Thalidomide in Myeloma
Status: WITHDRAWN
Conditions: Multiple Myeloma|Neoplasms|Plasma Cells|Paraproteinemias|Blood Protein Disorders|Hematologic Diseases|Therapeutic Uses
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dose Chemotherapy in Oligo-metastatic Homologous Recombination Deficient Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: carboplatin, thiotepa, and cyclophosphamide|DRUG: chemotherapy (docetaxel, doxorubicin, cyclofosfamide, carboplatin, paclitaxel, gemcitabine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Influence of Leutinizing Hormone (LH) on Oocyte Maturity
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: Cetrorelix|DRUG: Luprolide Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robot-Assisted Radical Prostatectomy With or Without Vesicopexy in Patients With Prostate Cancer
Status: RECRUITING
Conditions: Stage I Prostate Cancer AJCC v8|Stage II Prostate Cancer AJCC v8|Stage IIA Prostate Cancer AJCC v8|Stage IIB Prostate Cancer AJCC v8|Stage IIC Prostate Cancer AJCC v8|Stage III Prostate Cancer AJCC v8|Stage IIIA Prostate Cancer AJCC v8|Stage IIIB Prostate Cancer AJCC v8|Stage IIIC Prostate Cancer AJCC v8
Interventions: OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Radical Prostatectomy|PROCEDURE: Vesicopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Cryotherapy Modalities on Skin Temperature, Radial Artery Size and Flow Where Arterial Puncture Are Performed
Status: NOT_YET_RECRUITING
Conditions: Temperature|Blood Flow Velocity|Radial Artery Size
Interventions: DEVICE: Crushed ice|DEVICE: Frozen peas|DEVICE: Room temperature gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Aggressive Intravenous Hydration With Lactated Ringer's Solution for Prevention of Post-ESWL Pancreatitis
Status: RECRUITING
Conditions: Pancreatitis, Chronic|Pancreatic Duct Stone
Interventions: DRUG: Lactated ringers solution|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) Administered to Patients With Familial Chylomicronemia Syndrome (FCS)
Status: COMPLETED
Conditions: Familial Chylomicronemia Syndrome
Interventions: DRUG: Olezarsen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of L. Plantarum and P. Acidilactici in Children With Upper Respiratory Tract Infections
Status: TERMINATED
Conditions: Upper Respiratory Tract Infections|Pharyngitis|Tonsillitis
Interventions: DIETARY_SUPPLEMENT: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Melatonin in Patients Under Carotid Endarterectomy
Status: COMPLETED
Conditions: Carotid Stenosis
Interventions: DRUG: Melatonin|DRUG: placebo|OTHER: blank
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Upper Extremity Motor Function in Stroke Patients
Status: RECRUITING
Conditions: Stroke, Ischemic
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation|DEVICE: Sham Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: chronOS Inject in Proximal Tibial Fractures
Status: COMPLETED
Conditions: Closed Proximal Tibial Fracture Schatzker I - VI|Closed Proximal Tibial Fracture AO-OTA 41|Closed Proximal Tibial Fracture AO-OTA 42
Interventions: DEVICE: chronOS Inject
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess Adverse Events and Effectiveness of Injected JUVÉDERM® VOLITE™ Gel Filler for Change in Neck Lines in Adult Chinese Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Neck Lines
Interventions: DEVICE: JUVÉDERM® VOLITE™|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GetUp&Go: A Randomized Controlled Trial of an Intervention to Enhance Physical Activity After TBI
Status: RECRUITING
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: GetUp&Go|BEHAVIORAL: GetUp&Go with 10-Week Delay
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Immunogenicity of Combined Modified RNA Vaccine Candidates Against COVID-19 and Influenza
Status: COMPLETED
Conditions: Influenza, Human|COVID-19
Interventions: BIOLOGICAL: bivalent BNT162b2 (original/Omi BA.4/BA.5)|BIOLOGICAL: qIRV (22/23)|BIOLOGICAL: QIV|BIOLOGICAL: bIRV|BIOLOGICAL: tIRV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Patient-Centered Care for Opioid Use Disorders in Federally Qualified Healthcare Centers and Specialty Care Settings
Status: WITHDRAWN
Conditions: Opioid-use Disorder|Substance Use Disorders
Interventions: BEHAVIORAL: Individual Therapy Sessions|BEHAVIORAL: Cognitive Behavioral Therapy (CBT)|BEHAVIORAL: Medication-Assisted Treatment|BEHAVIORAL: Peer Recovery Specialist Support|BEHAVIORAL: Group Therapy Sessions|BEHAVIORAL: Psychiatric Consultation|BEHAVIORAL: Contingency Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Best Dose of Esketamine for Day Surgery of Pediatric Circumcision Pediatric Circumcision
Status: COMPLETED
Conditions: Phimosis
Interventions: DRUG: Esketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Treating Minimal Residual Disease in Patients With Acute Lymphoblastic Leukemia
Status: TERMINATED
Conditions: B Acute Lymphoblastic Leukemia|Minimal Residual Disease|Recurrent Acute Lymphoblastic Leukemia|T Acute Lymphoblastic Leukemia
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-012/KEYNOTE-012)
Status: COMPLETED
Conditions: Cancer|Solid Tumor
Interventions: BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sclerotherapy and Bone Marrow Injection In Aneurysmal Bone Cyst
Status: ACTIVE_NOT_RECRUITING
Conditions: Orthopedic Disorder
Interventions: PROCEDURE: Sclerotherapy With Adjuvant Bone Marrow Injection In Management of Aneurysmal Bone Cyst
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study of PEMF Therapy in Treatment of Post-operative Pain Following Total Knee Arthroplasty
Status: COMPLETED
Conditions: Post-Operative Pain Following Total Knee Arthroplasty
Interventions: DEVICE: Pulsed Electromagnetic Field Device (Provant)|DEVICE: Sham Pulsed Electromagnetic Field Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of The Second-line Treatment of Advanced Gastric / Gastroesophageal Junction Adenocarcinoma With Envafolimab and Lenvatinib Combined With Paclitaxel-albumin
Status: ENROLLING_BY_INVITATION
Conditions: Gastric / Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: envafolimab and lenvatinib combined with paclitaxel-albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lactated Ringer Versus Albumin in Early Sepsis Therapy
Status: COMPLETED
Conditions: Septic Shock|Severe Sepsis
Interventions: DRUG: Lactated Ringer|DRUG: Albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Apomorphine Effects on Pain in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: DRUG: Apomorphine Injectable Solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of VR647 and Conventionally Nebulized Budesonide in Healthy Volunteers and Adult Asthma Subjects
Status: COMPLETED
Conditions: Asthma
Interventions: COMBINATION_PRODUCT: VR647 Inhalation Suspension (budesonide) 1 mg/2 mL delivered by the VR647 Inhalation System (AKITA JET) with mouthpiece|COMBINATION_PRODUCT: VR647 Inhalation Suspension (budesonide) 1 mg/2 mL delivered by the VR647 Inhalation System (AKITA JET) with facemask|COMBINATION_PRODUCT: 1 mg/2 mL Pulmicort Respules delivered by a conventional jet nebulizer (PARI VIOS) with mouthpiece|COMBINATION_PRODUCT: 1 mg/2 mL Pulmicort Respules delivered by a conventional jet nebulizer (PARI VIOS) with facemask|COMBINATION_PRODUCT: 0.5 mg/2 mL Pulmicort Respules delivered by a conventional jet nebulizer (PARI VIOS) with mouthpiece|COMBINATION_PRODUCT: 0.5 mg/2 mL Pulmicort Respules delivered by a conventional jet nebulizer (PARI VIOS) with facemask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabetic Retinopathy Screening in Private Practice
Status: COMPLETED
Conditions: Diabetic Retinopathy
Interventions: OTHER: Free screening group|OTHER: Pay screening group ($150)|OTHER: Pay screening group ($300)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Plus Enfortumab Vedotin (EV) With and Without Pembrolizumab in Advanced Urothelial Carcinoma (MK-3475-04C/KEYMAKER-U04)
Status: RECRUITING
Conditions: Metastatic Urothelial Carcinoma|Locally Advanced Urothelial Carcinoma
Interventions: BIOLOGICAL: Sacituzumab tirumotecan|BIOLOGICAL: Enfortumab Vedotin|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Human Leptin Therapy Effects on Insulin Action
Status: COMPLETED
Conditions: Type Two Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: placebo|DRUG: low-dose leptin|DRUG: high-dose leptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fractional Flow Reserve Versus Angiographically Guided Management to Optimise Outcomes in Unstable Coronary Syndromes
Status: UNKNOWN
Conditions: NonST Elevation Myocardial Infarction|Myocardial Infarction
Interventions: DEVICE: Fractional flow reserve
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Dry Needling of the Gastrocnemius Muscle VS Electrolysis in Subjects With Achilles Tendinopathy
Status: RECRUITING
Conditions: Achilles Tendinopathy|Pain
Interventions: DEVICE: Dry needling|DEVICE: Electrolysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Implementation Of Outreach Behavioral Change Program for HCV Elimination
Status: COMPLETED
Conditions: Hepatitis C and B VIRUS Screening, Awareness and Behavior Assessment and Evaluation for All Inhabitants Above Twelve Years of Al Othmaneya Village
Interventions: BEHAVIORAL: behavioral development for change
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 1
Status: COMPLETED
Conditions: Nicotine Dependence, Other Tobacco Product
Interventions: DRUG: Nicotine|OTHER: Low Dose Menthol|OTHER: High Dose Menthol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of a Highly Selective Semipermeable Membrane (AN-69 Oxiris) vs (Standard AN-69) in COVID-19
Status: UNKNOWN
Conditions: Covid19|AKI
Interventions: PROCEDURE: AN69-Oxiris|PROCEDURE: AN69-Standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: OCT-guided DSAEK Graft Shaping and Smoothing
Status: TERMINATED
Conditions: Fuchs' Endothelial Dystrophy
Interventions: PROCEDURE: DSAEK with graft shaping and smoothing|PROCEDURE: Standard DSAEK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Sublingual dmLT for ETEC
Status: COMPLETED
Conditions: Gastroenteritis Escherichia Coli
Interventions: BIOLOGICAL: Recombinant Double Mutant Heat-Labile Toxin LT(R192G/L211A) (dmLT) Oral enterotoxigenic Escherichia coli (ETEC) Vaccine|BIOLOGICAL: Recombinant Double Mutant Heat-Labile Toxin LT(R192G/L211A) (dmLT) Oral enterotoxigenic Escherichia coli (ETEC) Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of GeranylGeranylAcetone in Heart Failure With Preserved Ejection Fraction
Status: ENROLLING_BY_INVITATION
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: DIAGNOSTIC_TEST: Iohexol measurement|DRUG: Geranylgeranylacetone (GGA)|DIAGNOSTIC_TEST: Echocardiography|DIAGNOSTIC_TEST: 6-minute walking distance test|DIAGNOSTIC_TEST: EndoPAT|DIAGNOSTIC_TEST: Para-amino Hippuric Acid test|DIAGNOSTIC_TEST: Electrocardiogram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant mFOLFOXIRI for Potentially Resectable Cholangiocarcinoma
Status: UNKNOWN
Conditions: Cholangiocarcinoma
Interventions: DRUG: mFOLFOXIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Demonstrate the Relative Bioavailability of Cetirizine Hydrochloride/Pseudoephedrine Hydrochloride 5 mg/120 mg Extended Release (ER) Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Allergies
Interventions: DRUG: Cetirizine HCl/Pseudoephedrine HCl 5 mg/120 mg Tablets (Sandoz, USA)|DRUG: Zyrtec-D 12 Hour 5 mg/120 mg Extended Release Tablets (Pfizer, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Safety Study of Oral Lofexidine in Neonates Experiencing Opioid Withdrawal Due to Intrauterine Exposure to Opioids
Status: RECRUITING
Conditions: Opioid Withdrawal (Disorder)
Interventions: DRUG: Standard of Care with Lofexidine|OTHER: Standard of Care without Lofexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Immunogenicity and Safety of the 9-valent Human Papillomavirus (9vHPV) Vaccine in Japanese Boys and Girls (V503-066)
Status: COMPLETED
Conditions: Papillomavirus Infections
Interventions: BIOLOGICAL: 9vHPV vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effects of Using Fertile Chip in Sperm Selection for Intracytoplasmic Sperm Injection in Unexplained Infertility
Status: COMPLETED
Conditions: Unexplained Infertility
Interventions: DEVICE: fertile chip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Barrett's Esophagitis in Anorexia Nervosa Binge/Purge Subtype
Status: NOT_YET_RECRUITING
Conditions: Barrett Esophagus|Anorexia Nervosa, Binge Eating/Purging Type|Rumination|Vomiting|Eating Disorders|Esophageal Adenocarcinoma
Interventions: DEVICE: EsoGuard
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pre-Exposure Prophylaxis With Hydroxychloroquine for High-Risk Healthcare Workers During the COVID-19 Pandemic
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Hydroxychloroquine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 1 Study Accessing the Safety and Tolerability of CBP-307
Status: COMPLETED
Conditions: Autoimmune Diseases
Interventions: DRUG: CBP-307|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First in Human Study to Compare Feasibility of Inertial Cavitation Irrigation to SNI in Root Canal Treatment.
Status: COMPLETED
Conditions: Root Canal Treatment|Post Operative Pain
Interventions: OTHER: Conventional irrigation|DEVICE: Inertial cavitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Growth Faltering Intervention Using Pediatric Nutritional Care (PNC) vs.PNC& FSMP
Status: ACTIVE_NOT_RECRUITING
Conditions: Growth Failure
Interventions: OTHER: High dense nutrients formula|OTHER: Pediatric Nutrition Care (PNC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LNK01001 Capsule in Patients With Ankylosing Spondylitis
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: DRUG: LNK01001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Neoplasm|Castleman Disease|Digestive System Carcinoma|Erdheim-Chester Disease|Lip and Oral Cavity Carcinoma|Lymphangioleiomyomatosis|Malignant Endocrine Neoplasm|Malignant Female Reproductive System Neoplasm|Malignant Male Reproductive System Neoplasm|Malignant Neoplasm|Malignant Respiratory Tract Neoplasm|Malignant Thoracic Neoplasm|Malignant Urinary System Neoplasm|Mesothelial Neoplasm|Metastatic Malignant Neoplasm|Metastatic Urothelial Carcinoma|Neurofibromatosis Type 2|Recurrent Adult Soft Tissue Sarcoma|Recurrent Breast Carcinoma|Recurrent Childhood Soft Tissue Sarcoma|Recurrent Digestive System Carcinoma|Recurrent Female Reproductive System Carcinoma|Recurrent Male Reproductive System Carcinoma|Recurrent Malignant Neoplasm|Recurrent Pharyngeal Carcinoma|Recurrent Thyroid Gland Carcinoma|Refractory Malignant Neoplasm|Soft Tissue Neoplasm|Stage III Breast Cancer AJCC v7|Stage III Pharyngeal Cancer|Stage IIIA Breast Cancer AJCC v7|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7|Stage IV Breast Cancer AJCC v6 and v7|Stage IV Pharyngeal Cancer|Stage IVA Pharyngeal Cancer|Stage IVB Pharyngeal Cancer|Stage IVC Pharyngeal Cancer|Thyroid Gland Neoplasm
Interventions: BIOLOGICAL: Bevacizumab|BIOLOGICAL: Cetuximab|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Temsirolimus|DRUG: Valproic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ascension PyroCarbon Radial Head Study
Status: TERMINATED
Conditions: Degenerative Arthritis|Radial Head Fracture|Rheumatoid Arthritis
Interventions: DEVICE: Carbon Modular Radial Head replacement|DEVICE: Metal Radial Head replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does Correction of 25 OH-VITAmin D With Cholecalciferol Supplementation Increase Muscle Strength in hemoDIALysis Patients?
Status: UNKNOWN
Conditions: hemoDIALysis Patients
Interventions: DRUG: Cholecalciferol 100.000 UI administration|OTHER: No vitamin D administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRD Assay Evaluates Recurrence and Response Via a Tumor Informed Assessment
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer|Solid Tumor|Non Small Cell Lung Cancer|Colorectal Cancer|Bladder Cancer
Interventions: DIAGNOSTIC_TEST: Personalized Cancer Monitoring (PCM)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Safety, Immune-Response and Efficacy of GSK Biologicals' EBV (Epstein Barr Virus) Vaccine (268664).
Status: COMPLETED
Conditions: Epstein Barr Virus (EBV) Infection
Interventions: BIOLOGICAL: EBV vaccine (268664)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Acupressure and Fistula Needle Insert Pain Management
Status: COMPLETED
Conditions: Chronic Kidney Disease Stage 5 (Disorder)
Interventions: BEHAVIORAL: Acupreesure applied
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Digital Phenotyping of Anxiety and Anxiety-Related Alcohol Co-occurrence: Pilot Study
Status: NOT_YET_RECRUITING
Conditions: Anxiety Disorders and Symptoms|PTSD|Alcohol Use Disorder
Interventions: BEHAVIORAL: Personalized intervention condition: Cognitive Behavioral Therapy skills|BEHAVIORAL: Therapeutic control condition: Cognitive Behavioral Therapy skills|BEHAVIORAL: Tracking control condition: Supportive counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Misoprostol Prior to Intrauterine Device (IUD) Insertion in Nulliparous Women
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Misoprostol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy and Tolerability of Two Cough Syrups in Cough Due to Cold in Children.
Status: COMPLETED
Conditions: Cough|Upper Respiratory Tract Infection
Interventions: DEVICE: protective cough syrup|DRUG: carbocisteine cough syrup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Music Breathing for Promoting Sense of Coherence in Young People: RCT
Status: NOT_YET_RECRUITING
Conditions: Sense of Coherence
Interventions: BEHAVIORAL: Music Breathing|BEHAVIORAL: Control condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Early Feasibility Study of Adaptive Advisory/Automated (AAA) Control of Type 1 Diabetes
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Overnight CLC|DEVICE: Sensor-Augmented Pump Therapy (SAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pembrolizumab and Tazemetostat to Overcome Immune Tolerance Following ASCT or CAR T-cell Therapy in Patients With Aggressive B-Cell Non-Hodgkin's Lymphoma
Status: NOT_YET_RECRUITING
Conditions: B-Cell Non-Hodgkin Lymphoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Echocardiography|BIOLOGICAL: Pembrolizumab|PROCEDURE: Positron Emission Tomography|DRUG: Tazemetostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Clinical Efficacy of 20-valent Pneumococcal Conjugate Vaccine (PCV20) in Lymphoma Survivors After Treatment With Anti-CD20 Therapy
Status: RECRUITING
Conditions: Lymphoma
Interventions: BIOLOGICAL: PCV20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Liver and Blood-stage Treatment on Subsequent Plasmodium Reinfection and Morbidity
Status: COMPLETED
Conditions: Plasmodium Vivax Infection|Plasmodium Vivax Clinical Episode|Plasmodium Falciparum Infection|Plasmodium Falciparum Clinical Episode
Interventions: DRUG: Primaquine|DRUG: Placebo|DRUG: Chloroquine|DRUG: Artemether Lumefantrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Magnesium Sulphate in the Ultrasound-guided Supraclavicular Brachial Plexus Block
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Magnesium Sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC