pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of L-Carnitine on Postprandial Clearance of Triglyceride-rich Lipoproteins in HIV Patients on HAART
Status: COMPLETED
Conditions: Hyperlipidemia|HIV Infections
Interventions: DIETARY_SUPPLEMENT: L-carnitine|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Looking at the Physiological Response of Ergometry in Critical Care Patients
Status: COMPLETED
Conditions: Critical Ill Patients
Interventions: DEVICE: Motomed cycle ergometer (MOTOmed letto2 - Reck, Reckstr 1-5, Betzenweiler 88422, Germany).
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vitamin D Supplementation in Healthy Adolescents
Status: COMPLETED
Conditions: Vitamin D Supplementation
Interventions: DRUG: Supplemental Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Parental Coping With Challenging Behavior in Mucopolysaccharidosis Type I-III
Status: COMPLETED
Conditions: Mucopolysaccharidosis Type I|Mucopolysaccharidosis Type II|Mucopolysaccharidosis Type III|Behavior Disorders|Coping Behavior
Interventions: OTHER: This is an observational study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of TXA127 and Neupogen to Increase Peripheral Blood Stem Cells (PBSCs)
Status: COMPLETED
Conditions: Miscellaneous Peripheral Blood Cell Abnormalities
Interventions: DRUG: TXA127|DRUG: Neupogen (filgrastim)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of a Comprehensive Health Status Assessment Scale in Elderly Patients (≥ 65 Years) With Hematological Malignancies
Status: COMPLETED
Conditions: Myelodysplastic Syndromes|Leukemia Myeloid Acute|Multiple Myeloma|Leuklemia, Lymphocytic, Chronic
Interventions: OTHER: Geriatric Assessment of Health Status Scale administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of GBT vs SRP+US, in the Treatment of Severe Generalized Periodontitis.
Status: COMPLETED
Conditions: Periodontitis, Aggressive|Periodontal Diseases|Periodontitis
Interventions: DEVICE: Airflow, Perioflow and Erythritol powder and ultrasonic debridement|DEVICE: Ultrasonic debridement and curettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Positive Airway Pressure Versus Breathing Exercises With Load Inspiratory in Patients Undergoing Bariatric Surgery
Status: COMPLETED
Conditions: Inadequate or Impaired Respiratory Function
Interventions: DEVICE: Bilevel positive airway pressure|DEVICE: PowerBreathe|PROCEDURE: Conventional Respiratory Physiotherapy (CRP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuropsychological Outcome After Cardiac Arrest
Status: COMPLETED
Conditions: Heart Arrest, Out-Of-Hospital|Hypoxia-Ischemia, Brain|Cognition Disorders|Psychological Distress|Fatigue|Insomnia
Interventions: DIAGNOSTIC_TEST: Neuropsychological assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Relative Bioavailability Study of Amlodipine Besylate 10 mg Tablets Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AMLODIPINE (as BESILATE) TABLETS 10 mg , single dose|DRUG: NorvasC® 10 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Comparison of 19g FNA and 19g FNB Needles for EUS-LB
Status: COMPLETED
Conditions: Abnormal Liver Function
Interventions: DEVICE: 19-gauge FNA needle|DEVICE: 19-gauge FNB needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Open-label Pilot Study to Assess the Use of Magic Foot™ in the Improvment of Parameters in Subject With Foot Symptoms
Status: COMPLETED
Conditions: Diabetes|Peripheral Vascular Disease
Interventions: DEVICE: Magic Foot™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study of A Fixed Combination of Timolol-Brimonidine-Dorzolamide
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: dorzolamide-timolol-brimonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Double-Blind,Randomized,Placebo-Controlled Efficacy & Safety Study of EUFLEXXA™ for Treatment of OA of the First CMC
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: sodium hyaluronate|DEVICE: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Prevention and Appropiate Obstetric Interventions for Prolonged Second Stage Labor at Term Pregnancies During Vaginal Delivery
Status: UNKNOWN
Conditions: Obstetric Labor Complications|Vacuum Extraction; Failure, Affecting Fetus or Newborn|Complicated Labour/Delivery Livebirth
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Efficacy and Safety of Ertugliflozin Monotherapy in the Treatment of Participants With Type 2 Diabetes Mellitus and Inadequate Glycemic Control Despite Diet and Exercise (MK-8835-003, VERTIS MONO)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Ertugliflozin 5 mg|DRUG: Ertugliflozin 10 mg|DRUG: Placebo to Ertugliflozin|DRUG: Metformin|DRUG: Placebo to Metformin|DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of the FIFA 11+ Injury Prevention Program on Performance & Movement Control in Young Female Athletes
Status: COMPLETED
Conditions: Injury of Anterior Cruciate Ligament
Interventions: OTHER: FIFA 11+ warm-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Mixed Working Memory Training on Subsequent Training Gains Among Older Adults
Status: COMPLETED
Conditions: Cognitive Aging
Interventions: BEHAVIORAL: Different Mixed Condition (DM)|BEHAVIORAL: Different Single Condition (DS)|BEHAVIORAL: Same Task (ST) Practice Control|BEHAVIORAL: Non-WM Placebo Control (PC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Community-based Cognitive Remediation and tDCS to Enhance Seniors' Function and Mental Health
Status: ACTIVE_NOT_RECRUITING
Conditions: Mental Health Disorder|Aging
Interventions: OTHER: Cognitive Remediation and Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Efficacy and Safety of Raphamin in the Treatment of ARVI in Children 12-18 Years Old
Status: COMPLETED
Conditions: Acute Respiratory Viral Infection
Interventions: DRUG: Raphamin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: International Study Evaluating the Safety and Efficacy of Inhaled, Human, Alpha-1 Antitrypsin (AAT) in Alpha-1 Antitrypsin Deficient Patients With Emphysema
Status: COMPLETED
Conditions: Emphysema
Interventions: BIOLOGICAL: Kamada AAT for inhalation|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Comparison of Duloxetine to Other Alternatives for the Management of Diabetic Peripheral Neuropathic Pain
Status: COMPLETED
Conditions: Diabetic Neuropathy, Painful
Interventions: DRUG: duloxetine hydrochloride|DRUG: pregabalin|DRUG: gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Use of Ophthalmic Viscosurgical Devices (OVD) FIDIAL PLUS vs IAL®-F During Cataract Surgery
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: FIDIAL PLUS|DEVICE: IAL®-F
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Pupilometer Guided Analgesia on Postoperative Pain
Status: COMPLETED
Conditions: Cholecystectomy, Laparoscopic|Anesthesia, General|Reflex, Pupillary
Interventions: PROCEDURE: Pupilometer guided anesthesia|PROCEDURE: SPI guided anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I Study in Healthy Male Subjects Comparing QGC001 to Placebo
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: QGC001 [(3S,3'S)-4,4'-dithiobis (3-aminobutane-1-sulfonic acid)]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Does Topical Ophthalmic Anesthetic Prior to Probing and Irrigation Decrease Pain?
Status: TERMINATED
Conditions: Epiphora|Dacryostenosis|Dacryocystitis
Interventions: DRUG: Proparacaine Hydrochloride ophthalmic solution, USP 0.5%|DRUG: Balanced salt solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Concomitant Vaccination With the Japanese Encephalitis Vaccine IC51 and HARVIX® 1440
Status: COMPLETED
Conditions: Japanese Encephalitis
Interventions: BIOLOGICAL: IC51|BIOLOGICAL: HAVRIX|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Aclidinium Bromide 400 µg BID (Twice a Day)Compared to Placebo in Patients With Stable Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Aclidinium Bromide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjusted Individual Oral Feeding for Improving Short and Long Term Outcomes of Preterm Infants
Status: UNKNOWN
Conditions: Body Weight Changes|Feeding and Eating Disorders of Childhood|Breast Feeding|Evoked Response Audiometry
Interventions: BEHAVIORAL: Adjusted individual feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare the Gastrointestinal Tolerability of Ferrochel®, Sumalate®,Ferrous Fumarate, Ferrous Sulfate, Ferric Glycinate, and Placebo
Status: UNKNOWN
Conditions: Anemia
Interventions: DIETARY_SUPPLEMENT: Ferrochel® 90 mg|DIETARY_SUPPLEMENT: Sumalate® 90 mg|DIETARY_SUPPLEMENT: Ferrous fumarate 90 mg|DIETARY_SUPPLEMENT: Ferrous Sulfate 90 mg|DIETARY_SUPPLEMENT: Ferric Glycinate 90 mg|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Erenumab in Adults With Medication Overuse Headache
Status: COMPLETED
Conditions: Migraine Headache
Interventions: DRUG: Erenumab 70 mg|DRUG: Erenumab 140 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mastopexy With Autologous Augmentation in Women After Massive Weight Loss - A Clinical, Randomized Study
Status: COMPLETED
Conditions: Weight Loss
Interventions: PROCEDURE: Rubins Mastopexy|PROCEDURE: LOPOSAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Lenalidomide, Venetoclax and Obinutuzumab in Patients With Treatment-Naïve Follicular Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Follicular Lymphoma
Interventions: DRUG: Obinutuzumab|DRUG: Venetoclax|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy (PDT) for Lower Urinary Tract Symptoms (PLUS)
Status: TERMINATED
Conditions: Prostatic Hyperplasia
Interventions: DRUG: Lemuteporfin for injection|DEVICE: Transurethral drug delivery system|DEVICE: Transurethral light delivery system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Phamacokinetics and Safety Profiles of DA-5210 10/1000mg in Healthy Subjects at Fasting State
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DA-5210 10/1000mg|DRUG: DA-5210-R 10/1000mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Paracetamol in Patients Over 80 Years Hospitalized to an Acute Geriatric Ward
Status: COMPLETED
Conditions: Pain
Interventions: PROCEDURE: Venopuncture for PK profiling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Biomarkers of Sleep-wake Cycle in Prodromal Alzheimer's Disease: Role in Cognitive Decline?
Status: RECRUITING
Conditions: Neuropathology
Interventions: PROCEDURE: Polysomnography|BEHAVIORAL: Neuropsychological assessment|BEHAVIORAL: Questionnaires on sleep and behavioural problems|PROCEDURE: Actimetry|DIAGNOSTIC_TEST: Fractional diuresis|PROCEDURE: Internal temperature measurement|OTHER: Biomarker assay
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Regenexx™ PL-Disc Versus Steroid Epidurals for Lumbar Radiculopathy
Status: TERMINATED
Conditions: Radiculopathy|Herniated Disc|Disc Degeneration
Interventions: PROCEDURE: Regenexx PL-Disc|PROCEDURE: Steroid Epidural
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PVB vs PECS Block in Breast Surgery
Status: COMPLETED
Conditions: Reconstruction Breast Surgery
Interventions: PROCEDURE: Paravertebral Thoracic block|PROCEDURE: Pectorals nerve block|DRUG: Levobupivacaine 0.25%|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuroplasticity:Melatonin and Transcranial Current Stimulation in Healthy Subjects.
Status: UNKNOWN
Conditions: Analgesia Disorder|Pain
Interventions: DEVICE: Transcranial Direct Current Stimulation (tDCS)|DRUG: Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hokusai Study in Pediatric Patients With Confirmed Venous Thromboembolism (VTE)
Status: COMPLETED
Conditions: Venous Thromboembolism (VTE)|Pulmonary Embolism|Deep Vein Thrombosis (DVT)
Interventions: DRUG: Edoxaban|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Assess the Efficacy of Botulinum Toxin A Treatments on Pain and Disability in Sub-Acute Low Back Pain
Status: TERMINATED
Conditions: Low Back Pain
Interventions: DRUG: Botulinum Toxin A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First-in-human Study to Evaluate the Safety and Tolerability of AZD8853 in Participants With Selected Advanced/Metastatic Solid Tumours
Status: TERMINATED
Conditions: Urinary Bladder Neoplasms|Colorectal Cancer|Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: AZD8853|DRUG: Zirconium-89 crefmirlimab berdoxam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Accuracy and Usability of the ACR | U.S. Urine Analysis Test System in the Lay User Hands
Status: COMPLETED
Conditions: Albuminuria
Interventions: DEVICE: ACR | U.S. Urine Analysis Test System|DEVICE: URiSCAN Optima Urine Analyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Hula Hooping as Compared to Walking on Adipose Tissue Distribution, Metabolic Parameters and Adipose Tissue Gene Expression
Status: COMPLETED
Conditions: Android Obesity, Metabolic Parameters and Adipose Tissue (AT) Gene Expression
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Comparison Between Two Different Parameters of Argon Plasma Coagulation in the Treatment of Chronic Radiation Proctitis: Historical Control Trial.
Status: COMPLETED
Conditions: Radiation Injuries|Telangiectasis|Rectal Bleeding
Interventions: PROCEDURE: Argon Plasma Coagulation|PROCEDURE: Historical control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of SIMBRINZA® BID as an Adjunctive to DUOTRAV®
Status: TERMINATED
Conditions: Open-angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Brinzolamide 1%/brimonidine tartrate 0.2% ophthalmic suspension|DRUG: Brinzolamide/brimonidine vehicle|DRUG: Travoprost 0.004%/timolol 0.5% solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Sitting and Standing Posture on Trunk Rotation in Patients With Idiopathic Scoliosis
Status: COMPLETED
Conditions: Scoliosis Idiopathic
Interventions: BEHAVIORAL: Corrected Sitting postures|BEHAVIORAL: Natural / relaxed sitting postures|BEHAVIORAL: Corrected Standing posture|BEHAVIORAL: Natural / relaxed standing postures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Stellate Ganglion Block and Cerebral Vasospasm
Status: RECRUITING
Conditions: Aneurysmal Subarachnoid Hemorrhage|Stellate Ganglion Block|Cerebral Vasospasm
Interventions: PROCEDURE: Stellate ganglion block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Health and Coping Prior to Ovarian Cancer Surgery
Status: COMPLETED
Conditions: Health and Coping Undergoing Ovarian Cancer Surgery.|Cancer Rehabilitation
Interventions: PROCEDURE: Preoperative preparation 2010
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mesh Versus Suture Repair in Umbilical Hernias - A Multicenter Trial
Status: COMPLETED
Conditions: Umbilical Hernia
Interventions: DEVICE: Onlay Mesh group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Retrospective Evaluation of the Intraocular Pressure Spikes With Loteprednol and Loteprednol/Tobramycin
Status: COMPLETED
Conditions: Ocular Hypertension
Interventions: DRUG: Loteprednol etabonate ophthalmic suspension 0.5%|DRUG: Loteprednol etabonate (0.5%) and tobramycin (0.3%).
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: GI Symptoms in Infants Fed GMF or CMF
Status: COMPLETED
Conditions: Gastrointestinal Diseases|Infant Nutrition Disorders
Interventions: DIETARY_SUPPLEMENT: Goat milk-based infant formula|DIETARY_SUPPLEMENT: Cow's milk-based infant formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alzheimer's Disease Neuroimaging Initiative 2
Status: COMPLETED
Conditions: Mild Cognitive Impairment (MCI)|Alzheimer's Disease (AD)|Significant Memory Concern (SMC)|Early Mild Cognitive Impairment (EMCI)|Late Mild Cognitive Impairment (LMCI)
Interventions: DRUG: Florbetapir|DRUG: Flortaucipir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Meal Frequency on Insulin Resistance in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Meal frequency (6 meals vs. 2 meals/day)|BEHAVIORAL: 6 meals/day followed by 2 meals/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Using Epigallocatechin Gallate (EGCG) and Cognitive Training to Modulate Cognitive Performance in Patients With Fragile X Syndrome" (TESFX)
Status: COMPLETED
Conditions: Fragile X Syndrome
Interventions: DIETARY_SUPPLEMENT: EGCG|DIETARY_SUPPLEMENT: Placebo|OTHER: Cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of TAP Block on Stress Hormones
Status: COMPLETED
Conditions: Abdominal Hysterectomy|Postoperative Pain
Interventions: PROCEDURE: TAP Block with Bupivicaine|PROCEDURE: TAP Block with Placebo drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics of Diammine Silver Fluoride
Status: COMPLETED
Conditions: Fluoride and Silver Pharmacokinetics of DSF Applied Topically to Teeth of Adults. Erythema, Bleeding, White Changes, Ulceration and Pigmentation Were Assessed
Interventions: DEVICE: DIammine SIlver Fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Selumetinib (AZD6244)(ARRY-142886) in Combination With Irinotecan in Previously Treated Patients With Colorec
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: AZD6244|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Whole-course Standardized Nutrition Management During Peri-radiotherapy in Patients With Nasopharyngeal Carcinoma After Radiotherapy: a Multicenter Randomized Controlled Clinical Study
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma|Radiation Therapy Induced Change|Nutrition Disorders
Interventions: DIETARY_SUPPLEMENT: Formula nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Improving Quality of Life in Older Patients With Frailty and Hematological Cancer Through Geriatric Assessment
Status: RECRUITING
Conditions: Hematologic Malignancy|Treatment Adherence|Treatment Complication|Frailty|Quality of Life
Interventions: OTHER: Comprehensive geriatric assessment (CGA) and treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Augmenting Exposure Therapy for Social Anxiety With Transcranial Direct Current Stimulation
Status: SUSPENDED
Conditions: Social Anxiety
Interventions: DEVICE: transcranial direct current stimulation|BEHAVIORAL: exposure therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Treatment With Oseltamivir
Status: COMPLETED
Conditions: Influenza, Human
Interventions: DRUG: Oseltamivir Oral Capsule for 5 days post-exposure|DRUG: Oseltamivir Oral Capsule for 10 days post-exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Suppression of Postprandial Monocyte Activation by Blueberries or Docosahexaenoic Acid in Humans
Status: COMPLETED
Conditions: Inflammation
Interventions: DIETARY_SUPPLEMENT: High saturated fat meal, placebo powder and sunflower oil|DIETARY_SUPPLEMENT: High saturated fat meal, blueberry powder and sunflower oil|DIETARY_SUPPLEMENT: High saturated fat meal, placebo powder and DHA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cyclosporine in Acute Myocardial Infarction Complicated by Cardiogenic Shock
Status: WITHDRAWN
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Single bolus of Placebo of CicloMulsion® (Neurovive).|DRUG: Single bolus of cyclosporine A (CicloMulsion®, Neurovive)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Protection of Transcutaneous Electrical Acupoint Stimulation in Gynecologic Laparoscopic Surgery
Status: SUSPENDED
Conditions: Reperfusion Injury
Interventions: DEVICE: electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 3 Study to Evaluate Immunogenicity and Safety of BBV154 Booster Dose
Status: COMPLETED
Conditions: COVID-19 Respiratory Infection
Interventions: BIOLOGICAL: BBV154 Intranasal Vaccine|BIOLOGICAL: Intramuscular vaccine COVAXIN|BIOLOGICAL: Covishield
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Non-inferiority and Safety Study of EuTCV Compared to Typbar-TCV in Healthy 6 Months-45 Years Aged Participants
Status: COMPLETED
Conditions: Typhoid Fever
Interventions: BIOLOGICAL: EuTCV (Vi-CRM Typhoid conjugate vaccine)|BIOLOGICAL: Typbar-TCV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of LCAR-HL30 in Subjects With Relapsed/Refractory Hodgkin's Lymphoma and Anaplastic Large Cell Lymphoma
Status: RECRUITING
Conditions: Hodgkin's Lymphoma|Anaplastic Large Cell Lymphoma
Interventions: BIOLOGICAL: LCAR-HL30 cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prevention Program to Encourage Self-care, Self-esteem and Body-esteem Among Young Adolescents
Status: UNKNOWN
Conditions: Primary Prevention
Interventions: BEHAVIORAL: Experiment: "Millie" prevention program, adolescents and active parents|BEHAVIORAL: Experiment: "Millie" prevention program, adolescents only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Omega-3 Supplementation on Nutritional Status and Physical Activity of Obese Children
Status: COMPLETED
Conditions: Life Style Modification|Childhood Obesity
Interventions: DIETARY_SUPPLEMENT: Omega 3|BEHAVIORAL: stage-based lifestyle modification intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Dosing Strategy of Intravitreal Ranibizumab for Pathological Myopia Choroidal Neovascularization
Status: COMPLETED
Conditions: Choroidal Neovascularization
Interventions: DRUG: 0.5mg intravitreal ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaginal Misoprostol Before Intrauterine Contraceptive Device Insertion
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Misoprostol|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cistanche Total Glycosides for Amyotrophic Lateral Sclerosis: A Randomized Control Trial (RCT) Study Assessing Clinical Response
Status: UNKNOWN
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Cistanche Total Glycosides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Residual Inflammatory Risk-Guided colcHicine in Elderly Trial
Status: NOT_YET_RECRUITING
Conditions: Percutaneous Coronary Intervention|Multivessel Coronary Artery Disease|Elderly Patients|C-Reactive Protein
Interventions: DRUG: colchicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cetuximab + BYL719 + IMRT (Intensity-Modulated Radiation Therapy) in Stage III/IVB Head and Neck Squamous Cell Cancer (HNSCC)
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Cancer
Interventions: DRUG: Cetuximab|DRUG: BYL719|RADIATION: IMRT (Intensity-Modulated Radiation Therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Lactobacillus Reuteri in Preventing Necrotizing Enterocolitis (NEC) in Pre-term Infants
Status: UNKNOWN
Conditions: Necrotizing Enterocolitis|Sepsis
Interventions: DRUG: Lactobacillus Reuteri DSM 17938|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: The Effects of a Single Intravenous Administration of Secukinumab (AIN457) or Canakinumab (ACZ885) in Dry Eye Patients
Status: COMPLETED
Conditions: Dry Eye
Interventions: BIOLOGICAL: Secukinumab 10 mg/kg|BIOLOGICAL: Canakinumab 10 mg/kg|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Mircera in the Treatment of Anemia in Patients With Chronic Kidney Disease Not on Dialysis
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: darbepoetin alfa|DRUG: methoxy polyethylene glycol-epoetin beta [Mircera]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PD-1 Blockade Combined With Chemotherapy Followed by Concurrent Immunoradiotherapy for Locally Advanced SCCA Patients
Status: ENROLLING_BY_INVITATION
Conditions: Anal Canal Cancer|Anal Squamous Cell Carcinoma|Anal Cancer|Anal Canal Cancer Stage I|Anal Canal Cancer Stage II|Anal Canal Cancer Stage III
Interventions: DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Telerehabilitation on Handwriting Performance in Children With ADHD: RCT
Status: COMPLETED
Conditions: Handwriting|Telerehabilitation|Fine Motor Skills
Interventions: OTHER: Fine Motor Skills Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation of Nasal Non-Invasive Ventilation With a RAM Cannula in the Inpatient /Outpatient Setting
Status: TERMINATED
Conditions: Chronic Respiratory Failure
Interventions: DEVICE: Nasal non-invasive ventilation with RAM cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Evolution of Neuroendoscopy Guided by Head-mounted Mixed Reality Technique Navigation System in Neurosurgery
Status: NOT_YET_RECRUITING
Conditions: Pineal Tumor|Brainstem Tumor|Surgery
Interventions: DEVICE: Conventinal Navigation System Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy Study of Triamcinolone and Bevacizumab Intravitreal for Treatment of Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Bevacizumab intravitreal|DRUG: Triamcinolone|DRUG: Triamcinolone + Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fentanyl Patch Pharmacokinetics in Healthy Adults
Status: COMPLETED
Conditions: Peer Review, Research
Interventions: DRUG: Intravenous fentanyl citrate|DRUG: Duragesic®|DRUG: Mylan generic fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of the Safety, Tolerability, and Efficacy of Relebactam (MK-7655) + Imipenem/Cilastatin Versus Imipenem/Cilastatin Alone to Treat Complicated Intra-Abdominal Infection [cIAI] (MK-7655-004)
Status: COMPLETED
Conditions: Intra-abdominal Infections
Interventions: DRUG: Relebactam 250 mg|DRUG: Relebactam 125 mg|DRUG: Imipenem/cilastatin|DRUG: Matching placebo to relebactam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Single Inhaled Doses of PT001, PT003, PT005 and PT001 Plus PT005 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: PT001|DRUG: PT005|DRUG: PT003|DRUG: PT001 + PT005
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EW and Self-Guided PST in Cancer Survivors and Caregivers
Status: SUSPENDED
Conditions: Cancer Survivors|Informal Caregivers
Interventions: BEHAVIORAL: Expressive Writing and Problem-Solving Therapy (EW+PST)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability, and Immunogenicity of Vaxelis™ in Children Previously Vaccinated With Vaxelis™ or Hexyon™ (V419-016)
Status: COMPLETED
Conditions: Vaccines, Combined|Hexavalent Vaccine
Interventions: BIOLOGICAL: Vaxelis™
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Diclofenac Potassium Alone Versus Diclofenac Potassium With Hyoscine-N-butyl Bromide (HBB in Endoscopy
Status: COMPLETED
Conditions: Pain
Interventions: DIAGNOSTIC_TEST: Diclofenac + HBB with hysteroscopy|DIAGNOSTIC_TEST: Diclofenav + placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Safety and Efficacy of Once Monthly Ranibizumab Injections in Chinese Patients With Wet Age Related Macular Degeneration (AMD) Patients
Status: COMPLETED
Conditions: Age Related Macular Degeneration
Interventions: DRUG: ranibizumab 0.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine in Off Pump Coronary Artery Bypass Grafting
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DRUG: Dexmedetomidine|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Cadonilimab in Combination With Chemotherapy for Locally Advaced Esophageal Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Resectable Esophageal Squamous Cell Carcinoma|Neoadjuvant Therapy
Interventions: DRUG: cadonilimab+chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Active Immunotherapy (Vaccine Therapy) and Sargramostim Given After Standard of Care Treatment With Rituximab and Chemotherapy for Initial Treatment With Lymphoma
Status: TERMINATED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: autologous immunoglobulin idiotype-KLH conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Evaluating the Effectiveness of a Community Based Intervention for Persons With Dementia and Their Caregivers in a Developing Country
Status: COMPLETED
Conditions: Dementia|Behavioral Symptoms|Mental Health
Interventions: BEHAVIORAL: Home based, flexible, stepped care intervention|BEHAVIORAL: Home based, flexible, stepped care intervention after 6 months. Families will be free to choose any health care they desire during the waiting period.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CAR-T Following ASCT for Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (R/R B-NHL) With High-Risk Prognostic Factors
Status: RECRUITING
Conditions: B-cell Non Hodgkin Lymphoma
Interventions: OTHER: autologous stem-cell transplantation|DRUG: Relmacabtagene autoleucel (relma-cel)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nitrocamptothecin or Fluorouracil in Treating Patients With Recurrent or Refractory Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: DRUG: fluorouracil|DRUG: rubitecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Posterior Percutaneous Pedicle Screw Fixation for Acute Thoracolumbar Vertebral Fractures
Status: COMPLETED
Conditions: Vertebral Fracture
Interventions: PROCEDURE: posterior percutaneous pedicle screw internal fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Benefit of Venetoclax Plus Rituximab Compared With Bendamustine Plus Rituximab in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Bendamustine|DRUG: Venetoclax|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ostrobothnia Depression Study (ODS). A Naturalistic Follow-up Study on Depression and Related Substance Use Disorders
Status: COMPLETED
Conditions: Major Depression|Dual Diagnosis|Anxiety Disorders|Substance Related Disorders
Interventions: BEHAVIORAL: Behavioral Activation|BEHAVIORAL: Motivational Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Relative Bioavailability Study of Two Montelukast Sodium (GW483100) 5 Milligrams (mg) Chewable Tablets and One Reference Montelukast Sodium 5 mg Chewable Tablet in Healthy Adult Subjects
Status: COMPLETED
Conditions: Respiratory Disorders
Interventions: DRUG: Reference Montelukast|DRUG: Test 1 Montelukast|DRUG: Test 2 Montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CARTALL: Chimeric-Antigen Receptor (CAR) T-Cell Therapy for Relapsed/ Refractory T-Lineage Acute Lymphoblastic Leukaemia
Status: RECRUITING
Conditions: Lymphoblastic Leukemia, Acute, Childhood|Lymphoblastic Leukemia|Lymphoblastic Leukemia, Acute Adult|Lymphoblastic Leukemia in Children|CAR|CAR T-Cell-Related Encephalopathy Syndrome|Refractory Leukemia
Interventions: BIOLOGICAL: CAR T-cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Addition of Dry Needling in the Treatment of Patients With Patellofemoral Pain Syndrome
Status: WITHDRAWN
Conditions: Patellofemoral Pain Syndrome
Interventions: OTHER: Intramuscular Dry Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficiency of Clear Aligners in Maxillary Molar Distalization: A Randomized Clinical Trial.
Status: RECRUITING
Conditions: Orthodontic Aligners
Interventions: DEVICE: Molar distalization by aligners with attachment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel Intermittent-Erlotinib (Tarceva®) In Metastatic Non Small Cell Lung Cancer (NSCLC)
Status: TERMINATED
Conditions: Advanced Non-Small Cell Lung Cancer
Interventions: DRUG: Erlotinib, Docetaxel|DRUG: Docetaxel, Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 2 Week, Crossover Trial of Dietary Nitrate in Obstructive Sleep Apnoea Syndrome (OSAS).
Status: COMPLETED
Conditions: Obstructive Sleep Apnoea Syndrome
Interventions: DIETARY_SUPPLEMENT: Dietary nitrate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Epidermal Growth Factor Receptor (EGFR) Antagonist Chimeric Anti-EGFR Monoclonal Antibody Trial
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: KL-140|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Clinical Trial of Allopurinol to Prevent Kidney Function Loss in Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetic Nephropathies|Coronary Artery Disease
Interventions: DRUG: Allopurinol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of DKN-01 and Lenalidomide/Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: DKN-01 300 mg|DRUG: DKN-01 600 mg|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brown Adipose Tissue Activity and Thyroid Hormone
Status: COMPLETED
Conditions: Hypothyroidism|Hyperthyroidism|Obesity
Interventions: OTHER: Levothyroxine therapy (137.75 ± 23.75 μg/day)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of VX-445 in Healthy Subjects and Subjects With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: IVA|DRUG: TEZ/IVA|DRUG: VX-445|DRUG: Matched Placebo|DRUG: TEZ|DRUG: VX-561|DRUG: VX-445
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Combined Aerobic and Resistance Training in Patients With Intermittent Claudication
Status: UNKNOWN
Conditions: Peripheral Arterial Disease|Endothelial Dysfunction
Interventions: BEHAVIORAL: combined aerobic and resistance physical activity|BEHAVIORAL: sham exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Additional Effects of Quranic Listening Meditation in Combination With High Intensity Interval Training in Obese Adults
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: High Intensity interval training + Quranic Listening|OTHER: High intensity interval training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pulse Pressure Variation for Prediction of Fluid Responsiveness in Coronary Artery Disease Patients With Diastolic Dysfunction
Status: COMPLETED
Conditions: Fluid Responsiveness Predictability
Interventions: DRUG: Fluid loading (Voluven)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Macrophage Programing in Acute Lung Injury: MiniBAL
Status: RECRUITING
Conditions: Acute Respiratory Distress Syndrome|Ventilator Associated Pneumonia
Interventions: OTHER: Non-Bronchoscopic Mini Bronchoalveolar Lavage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE