pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Friendship Based HIV/STI (Sexually Transmitted Infections) Intervention for African American Females
Status: COMPLETED
Conditions: Sexual Behavior|Sexually Transmitted Diseases|HIV Infections
Interventions: BEHAVIORAL: Project ÒRÉ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Open-label, Randomized, Active-controlled Study of LEV Used as Monotherapy in Patients With Partial-Onset Seizures
Status: COMPLETED
Conditions: Epilepsy|Partial Seizures
Interventions: DRUG: Levetiracetam|DRUG: Carbamazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of a N, N-dimethyltryptamine (DMT) Analog (CYB004) in Participants With Generalized Anxiety Disorder (GAD)
Status: RECRUITING
Conditions: Generalized Anxiety Disorder
Interventions: DRUG: CYB004|BEHAVIORAL: Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Conventional and Model-based Infusion Strategy of IV PCA in Patients Undergoing RALP
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial Comparing Efficacy and Safety of Exubera® and Humalog®
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Inhaled Human Insulin (Exubera®)|DRUG: Insulin lispro (Humalog)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of a PEG Membrane and a Collagen Membrane for the Treatment of Bone Dehiscence Defects at Bone Level Implants
Status: COMPLETED
Conditions: Degeneration; Bone
Interventions: DEVICE: barrier membrane|DEVICE: MembraGel|OTHER: Bio-Gide® membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Wellbeing for Women With Depression: A Pragmatic Randomised Controlled Trial (RCT) of an Exercise Programme
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Psychosocial support exercise programme|BEHAVIORAL: Prescribed exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Tisotumab Vedotin (HuMax®-TF-ADC) Safety Study in Patients With Solid Tumors
Status: COMPLETED
Conditions: Ovary Cancer|Cervix Cancer|Endometrium Cancer|Bladder Cancer|Prostate Cancer (CRPC)|Esophagus Cancer|Lung Cancer (NSCLC)
Interventions: DRUG: Tisotumab vedotin (HuMax-TF-ADC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study to Establish the Efficacy of Oral Ice Exposure During Oxaliplatin Infusion in Preventing Oral Cold Sensitivity
Status: TERMINATED
Conditions: GI Patients on Oxaliplatin Containing Regimen
Interventions: DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testosterone Revival Abolishes Negative Symptoms, Fosters Objective Response and Modulates Enzalutamide Resistance
Status: COMPLETED
Conditions: Castration Resistant Metastatic Prostate Cancer
Interventions: DRUG: Testosterone cypionate|DRUG: Enzalutamide|DRUG: Testosterone Enanthate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Evaluation of the Tension-Free Vaginal Tape Obturator System For Treatment of Stress Urinary Incontinence (Urinary Leakage)
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: Tension-free vaginal tape obturator system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: The Effects of Kegel Pelvic Floor Muscle Exercises on Urinary Retention and Comfort Levels
Status: ENROLLING_BY_INVITATION
Conditions: Nurses|Comfort|Surgery
Interventions: OTHER: Kegel Pelvic Floor Muscle Exercise Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study Study to Investigate the Effect on QT/QTc Interval of Moxifloxacin After a Single Dose in Healthy Male Subjects
Status: COMPLETED
Conditions: the Effect of Moxifloxacin on QT/QTc Interval
Interventions: DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mask Study: One-handed vs. Two Handed Technique in Children
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: PROCEDURE: One handed mask airway, switch to two hands|PROCEDURE: Two handed mask airway + jaw thrust|PROCEDURE: Two handed mask airway, switch to one hand
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pilot Study With the Aim to Quantify a Stress Protein in the Blood and in the Urine for the Monitoring and Early Diagnosis of Malignant Solid Tumors
Status: COMPLETED
Conditions: Cancer
Interventions: OTHER: blood samples|OTHER: Urine samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Trial to Evaluate the Safety Tolerability and Pharmacokinetics of B1344 by Subcutaneous Injection in Healthy Subjects
Status: RECRUITING
Conditions: Nonalcoholic Steatohepatitis
Interventions: DRUG: B1344|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biospecimen Collection and Testing for the Prevalence of Anal Dysplasia and Anal Cancer in Patients With Cervical, Vaginal and Vulvar Dysplasia and Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Adenocarcinoma|Cervical Adenocarcinoma In Situ|Cervical Intraepithelial Neoplasia|Cervical Squamous Cell Carcinoma, Not Otherwise Specified|Cervical Squamous Intraepithelial Neoplasia|Early Invasive Cervical Adenocarcinoma|Early Invasive Cervical Squamous Cell Carcinoma|High Grade Cervical Squamous Intraepithelial Neoplasia|High Grade Vaginal Intraepithelial Neoplasia|Low Grade Vaginal Intraepithelial Neoplasia|Stage I Cervical Cancer AJCC v8|Stage I Vaginal Cancer AJCC v8|Stage I Vulvar Cancer AJCC v8|Stage IA Cervical Cancer AJCC v8|Stage IA Vaginal Cancer AJCC v8|Stage IA Vulvar Cancer AJCC v8|Stage IA1 Cervical Cancer AJCC v8|Stage IA2 Cervical Cancer AJCC v8|Stage IB Cervical Cancer AJCC v8|Stage IB Vaginal Cancer AJCC v8|Stage IB Vulvar Cancer AJCC v8|Stage IB1 Cervical Cancer AJCC v8|Stage IB2 Cervical Cancer AJCC v8|Stage II Cervical Cancer AJCC v8|Stage II Vaginal Cancer AJCC v8|Stage II Vulvar Cancer AJCC v8|Stage IIA Cervical Cancer AJCC v8|Stage IIA Vaginal Cancer AJCC v8|Stage IIA1 Cervical Cancer AJCC v8|Stage IIA2 Cervical Cancer AJCC v8|Stage IIB Cervical Cancer AJCC v8|Stage IIB Vaginal Cancer AJCC v8|Stage III Cervical Cancer AJCC v8|Stage III Vaginal Cancer AJCC v8|Stage III Vulvar Cancer AJCC v8|Stage IIIA Cervical Cancer AJCC v8|Stage IIIA Vulvar Cancer AJCC v8|Stage IIIB Cervical Cancer AJCC v8|Stage IIIB Vulvar Cancer AJCC v8|Stage IIIC Vulvar Cancer AJCC v8|Stage IV Cervical Cancer AJCC v8|Stage IV Vaginal Cancer AJCC v8|Stage IV Vulvar Cancer AJCC v8|Stage IVA Cervical Cancer AJCC v8|Stage IVA Vaginal Cancer AJCC v8|Stage IVA Vulvar Cancer AJCC v8|Stage IVB Cervical Cancer AJCC v8|Stage IVB Vaginal Cancer AJCC v8|Stage IVB Vulvar Cancer AJCC v8|Vaginal Adenocarcinoma|Vulvar Adenocarcinoma|Vulvar High Grade Squamous Intraepithelial Lesion|Vulvar Intraepithelial Neoplasia|Vulvar Squamous Cell Carcinoma|Vulvar Squamous Intraepithelial Lesion
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Comparison of the Outcomes in Fortiva and Strattice Mesh
Status: RECRUITING
Conditions: Ventral Hernia
Interventions: DEVICE: Propspective VHR with Fortiva|DEVICE: RetroSpective VHR with Strattice
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Grazoprevir (MK-5172) + Elbasvir (MK-8742) in Chronic Hepatitis C Participants With Child-Pugh (CP)-B Hepatic Insufficiency (MK-5172-059)
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Grazoprevir|DRUG: Elbasvir|DRUG: MK-5172A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acyclovir to Treat Patients Co-infected With HIV and Herpes Viruses in Uganda
Status: COMPLETED
Conditions: HIV Infections|Herpes Genitalis
Interventions: DRUG: Acyclovir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Biodistribution, Metabolism, Excretion and Brain Uptake11C-M503
Status: RECRUITING
Conditions: Tauopathies
Interventions: DRUG: 11C-M503 PET|DIAGNOSTIC_TEST: Brain MRI|DIAGNOSTIC_TEST: Amyloid PET|BEHAVIORAL: Neurological assessments
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients
Status: SUSPENDED
Conditions: Infection|Hypervolemia|Hypovolemia|Septic Shock|Acute Heart Failure|Congestive Heart Failure
Interventions: PROCEDURE: Peripheral Intravenous Analysis (PIVA)|PROCEDURE: Non-invasive fluid response measure|DIAGNOSTIC_TEST: Passive leg raise (PLR)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase II Trial of the DNA Methyl Transferase Inhibitor, Guadecitabine (SGI-110), in Children and Adults With Wild Type GIST,Pheochromocytoma and Paraganglioma Associated With Succinate Dehydrogenase Deficiency and HLRCC-associated Kidney Cancer
Status: TERMINATED
Conditions: Paraganglioma|Gastrointestinal Stromal Tumors|Carcinoma, Renal Cell|Renal Neoplasms|Pheochromocytoma
Interventions: DRUG: SGI-110 (guadecitabine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cough and Swallow Rehab Following Stroke
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: BEHAVIORAL: Expiratory muscle strength training|BEHAVIORAL: Placebo expiratory training|DRUG: Measures performed on all subjects|BEHAVIORAL: Pulmonary function test|RADIATION: Fluoroscopic swallow study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Preservative-free 0.0015% Tafluprost in Glaucoma Patients
Status: COMPLETED
Conditions: Primary Open-angle Glaucoma
Interventions: DRUG: Benzalkonium chloride (BAK)|DRUG: 0.0015% tafluprost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperatively Walking's Effect of Postoperative Bowel Functions in Patient With Gynecologic Cancer.
Status: COMPLETED
Conditions: Postoperative Bowel Functions
Interventions: OTHER: walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Unified Protocol: Community Connections
Status: RECRUITING
Conditions: Mental Health Issue|Anxiety Disorder|Depressive Disorder|Parenting
Interventions: BEHAVIORAL: The Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Children|BEHAVIORAL: The Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Adolescents
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study to Investigate the Occurrence of Bleeding in Postmenopausal Women Treated With Estradiol/NETA for 12 Months
Status: COMPLETED
Conditions: Menopause|Postmenopausal Bleeding
Interventions: DRUG: 0.5 mg estradiol / 0.1 mg norethisterone acetate (NETA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Observational Study of Insulin Aspart and, if Necessary, Insulin Levemir (FlexPen®) in the Evening or at Bedtime
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin aspart|DRUG: insulin detemir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: NPWT PRO vs KCI Ulta® NPWT and to Compare NPWT PRO vs NPWT PRO With Simultaneous Irrigation on Wound Healing
Status: COMPLETED
Conditions: Partial-thickness Burn|Ulcer
Interventions: DEVICE: NPWT PRO without irrigation|DEVICE: NPWT PRO with irrigation|DEVICE: KCI Ulta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Everolimus and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin Lymphoma
Status: COMPLETED
Conditions: Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hepatosplenic T-cell Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Peripheral T-cell Lymphoma|Post-transplant Lymphoproliferative Disorder|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Splenic Marginal Zone Lymphoma|Waldenstrom Macroglobulinemia
Interventions: DRUG: everolimus|DRUG: lenalidomide|OTHER: laboratory biomarker analysis|GENETIC: polymorphism analysis|OTHER: immunohistochemistry staining method|GENETIC: microarray analysis|GENETIC: fluorescence in situ hybridization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trilaciclib Prior to Chemotherapy Plus Tislelizumab as 1L Treatment for Advanced Squamous Non-Small-Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Advanced Squamous Non-Small-Cell Lung Cancer
Interventions: DRUG: Trilaciclib|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect Alveolar Recruitment Manoeuver on Stroke Volume a Randomized Study
Status: UNKNOWN
Conditions: Alveolar Recruitment Manoeuver|Anesthesia
Interventions: PROCEDURE: alveolar recruitment manoeuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Efficacy of the Erchonia Corporation THL™ for Providing Relief of Tinnitus Symptoms
Status: TERMINATED
Conditions: Tinnitus
Interventions: DEVICE: Erchonia® THL™|DEVICE: Placebo Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Randomized and Phase 2 Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of Pembrolizumab
Status: SUSPENDED
Conditions: Melanoma
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Aldesleukin|DRUG: Pembrolizumab|BIOLOGICAL: young TIL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medical & Economical Evaluation of Fenestrated & Branched Stent-grafts to Treat Complex Thoracal Abdominal Aneurysms
Status: UNKNOWN
Conditions: Aortic Aneurysm
Interventions: PROCEDURE: Endovascular aortic repair|PROCEDURE: Open surgical repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary and Secondary Elevations of Maxillary Sinuses: a Prospective Clinical Study in the Posterior Maxillary Region
Status: RECRUITING
Conditions: Tooth Loss
Interventions: PROCEDURE: Transalveolar crest maxillary sinus floor lift|PROCEDURE: transalveolar crest parietal maxillary sinus floor secondary lift
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Objective Double-blind Evaluation of Bupropion and Citalopram in an Individual With Friedreich Ataxia
Status: COMPLETED
Conditions: Friedreich Ataxia
Interventions: DRUG: bupropion & Citalopram|DRUG: Bupropion & Placebo|DRUG: Placebo & Citalopram|DRUG: Placebo & Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor, in Participants With Treatment Resistant Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Esketamine 28 mg|DRUG: Esketamine 56 mg|DRUG: Esketamine 84 mg|DRUG: Quetiapine XR 50 mg|DRUG: Quetiapine XR 100 mg|DRUG: Quetiapine XR 150 mg|DRUG: SSRI/SNRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gliadel Wafer and O6-Benzylguanine in Treating Patients With Recurrent Glioblastoma Multiforme
Status: COMPLETED
Conditions: Recurrent Adult Brain Tumor
Interventions: DRUG: Gliadel wafers in combination with O6-benzylguanine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effectiveness and Safety of Different Doses of Fluticasone Propionate Taken From a Dry Powder Inhaler in Adolescents and Adults Who Have Asthma That is Not Controlled by Asthma Medications Not Containing Steroids
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fp MDPI|DRUG: Flovent Diskus|DRUG: albuterol/salbutamol|DRUG: Placebo MDPI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sentinel Lymph Node Biopsy to Assess Axillary Lymph Nodes in Women With Stage I or Stage II Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: patent blue V dye|PROCEDURE: conventional surgery|PROCEDURE: lymphangiography|PROCEDURE: radionuclide imaging|PROCEDURE: sentinel lymph node biopsy|RADIATION: Technetium Tc 99m human serum albumin colloid
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Coronal Mode Ultrasound Guided Hemodialysis Cannulation: Comparison With Standard Cannulation Technique
Status: COMPLETED
Conditions: Arteriovenous Fistula, Cannulation
Interventions: DEVICE: Sonic Window ultrasound device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Posterior Capsule Opacification (PCO) Evaluation of the AcrySof SN60AT Lens vs. SN60WF Lens
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: SN60AT|DEVICE: SN60WF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Interventions for Hospital Medical Thromboprophylaxis: a Bicentric Swiss Quality-improvement Study
Status: RECRUITING
Conditions: Venous Thromboembolism
Interventions: OTHER: Comprehensive electronic tool in the electronic medical chart|OTHER: Educative sessions|OTHER: Pocket card
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Methodologies for Measuring Swelling of the Leg and Ankle (MK-0000-106)(COMPLETED)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Comparator: amlodipine besylate|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of the Effects of Minocycline on Cognitive Function After Carotid Endarterectomy
Status: WITHDRAWN
Conditions: Carotid Stenosis
Interventions: DRUG: Minocycline|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Long-term Safety, Tolerability and Efficacy of BAF312 Given Orally in Patients With Relapsing-remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: BAF312
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colchicine for Diabetic Nephropathy Trial
Status: UNKNOWN
Conditions: Diabetic Nephropathies
Interventions: DRUG: Colchicine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diurnal Variation of Plasminogen Activator Inhibitor-1
Status: COMPLETED
Conditions: Metabolic Syndrome X
Interventions: DRUG: Eplerenone (Morning)|DRUG: Eplerenone (Night-time)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PD-1 Antibody + Apatinib Mesylate in 2+ Line Serum AFP-elevated Gastric Adenocarcinoma
Status: UNKNOWN
Conditions: Gastric Cancer|AFP
Interventions: DRUG: PD-1 antibody|DRUG: Apatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0000D: Effect of Vitamin E and/or Selenium on Colorectal Polyps in Men Enrolled on SELECT Trial SWOG-S0000
Status: COMPLETED
Conditions: Colorectal Cancer|Precancerous Condition
Interventions: DRUG: Vitamin E|DRUG: Selenium|DRUG: Vitamin E placebo|DRUG: selenium placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) With Bevacizumab and Irinotecan for Malignant Glioma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: bevacizumab|DRUG: irinotecan|PROCEDURE: dynamic contrast-enhanced magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cannabis and Polysubstance Use: Response Inhibition and Stress Exposure
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: Cannabis oil with a high ratio of THC to CBD|DRUG: Cannabis oil with a high ratio of CBD to THC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Facilitated Tucking After Vaginal Delivery on Late Preterm Stress, Comfort and Physiological Parameters
Status: COMPLETED
Conditions: Preterm Labor|Preterm Labor With Preterm Delivery in Third Trimester|Preterm Spontaneous Labor With Preterm Delivery
Interventions: OTHER: Assessment of physiological parameters|OTHER: Assessment of Stress|OTHER: Assessment of Comfort
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Multi-Center Environmental Study for the Treatment of Moderate to Severe Ocular Allergic Conjunctivitis
Status: COMPLETED
Conditions: Allergic Conjunctivitis (AC)
Interventions: DRUG: EBI-005|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: COPD-Related Physiology and the Brain
Status: RECRUITING
Conditions: Pulmonary Disease, Chronic Obstructive (COPD)|Cognitive Impairment
Interventions: BEHAVIORAL: Neuropsychological Assessment|PROCEDURE: Spirometry|PROCEDURE: Arterial Blood Gas|PROCEDURE: Diffusion Capacity of the Lung for Carbon Monoxide|DIAGNOSTIC_TEST: 6 Minute Walk Test|PROCEDURE: Systemic Vascular Measures|BIOLOGICAL: Blood Biomarkers|BEHAVIORAL: Symptom Questionnaire Measures|PROCEDURE: Brain MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vitiligo Treatment by Targeting TYK2 Mediated Responses
Status: RECRUITING
Conditions: Vitiligo, Generalized
Interventions: DRUG: Deucravacitinib|OTHER: Volunteer without treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Curcuminoids From Turmipure Gold® in Different Food Matrices
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: TPG capsule|DIETARY_SUPPLEMENT: TPG ready to drink|DIETARY_SUPPLEMENT: TPG dairy analog|DIETARY_SUPPLEMENT: TPG probiotic drink|DIETARY_SUPPLEMENT: TPG gummies|DIETARY_SUPPLEMENT: TPG sport bar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Design Validation of Senofilcon A With New UV-blocking Additive
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: senofilcon A TEST Lens|DEVICE: senofilcon A CONTROL Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect and Safety of AZD6765 in Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: AZD6765 iv|DRUG: AZD6765 iv|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Dry Cold Application on Pain and Bruise at the Subcutaneous Injection Site Among Patients Admitted in ICU
Status: COMPLETED
Conditions: Pain|Bruise
Interventions: OTHER: Dry cold application|OTHER: sub cutaneous injection (low molecular weight heparin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease
Status: COMPLETED
Conditions: Degenerative Disc Disease
Interventions: DEVICE: HEALOS and Leopard Cage|DEVICE: Leopard Cage and Autograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blinking and Yawning in Epilepsy: The Role of Dopamine
Status: COMPLETED
Conditions: Idiopathic Generalized Epilepsy
Interventions: OTHER: Apomorphine (Experimental product)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Positions on Physiological Parameters of Preterm Neonates Receiving Mechanical Ventilation
Status: COMPLETED
Conditions: Preterm|Nursing Caries
Interventions: OTHER: The Effect of Supine Position on Physiological Parameters in Mechanically Ventilated Preterm Newborns|OTHER: The Effect of Prone Position on Physiological Parameters in Mechanically Ventilated Preterm Newborns|OTHER: The Effect of left lateral Position on Physiological Parameters in Mechanically Ventilated Preterm Newborns|OTHER: The Effect of right lateral Position on Physiological Parameters in Mechanically Ventilated Preterm Newborns|OTHER: The Effect of Quarter prone Position on Physiological Parameters in Mechanically Ventilated Preterm Newborns
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Application of Different Modes of Esketamine Administration in Pediatric Day Circumcision
Status: NOT_YET_RECRUITING
Conditions: Pain
Interventions: DRUG: Esketamine of single injection|DRUG: Esketamine of Intermittent injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Probiotic on Prevention of GBS Vaginal Infection During Pregnancy
Status: COMPLETED
Conditions: Infection, Bacterial
Interventions: DIETARY_SUPPLEMENT: Probiotic capsule GR-1 and RC-14|DIETARY_SUPPLEMENT: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Use of Sugammadex for Reversal of Paralysis in Microlaryngoscopy
Status: RECRUITING
Conditions: Microlaryngoscopy|Rigid Bronchoscopy
Interventions: DRUG: Sugammadex|DRUG: neostigmine|DRUG: glycopyrrolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of Cediranib (AZD2171) in Japanese Metastatic Colorectal Cancer Patients in Combination With FOLFOX
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: AZD2171|DRUG: FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin)|DRUG: Placebo Cediranib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dosing and Effectiveness Study of Sorafenib and RAD001 in the Treatment of Patients With Advanced Kidney Cancer
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: DRUG: Sorafenib|DRUG: RAD001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Single Subcutaneous Dose Study of MLN1202
Status: WITHDRAWN
Conditions: Healthy Japanese and Caucasian Male Adults
Interventions: DRUG: MLN1202|DRUG: MLN1202 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thoracic Paravertebral Block in Daytime Laparoscopic Partial Adrenalectomy
Status: NOT_YET_RECRUITING
Conditions: Laparoscopic Adrenalectomy|Day Surgery
Interventions: PROCEDURE: thoracic paravertebral block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: for Adipose Tissue DIabetes VAriants (fATDIVA)
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: OTHER: Oral Triglyceride Tolerance Test (OTTT)|PROCEDURE: Abdominal fat biopsy (optional)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tarceva and Capecitabine for Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer|Neoplasm Metastasis
Interventions: DRUG: Capecitabine|DRUG: OSI-774
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mortality and Symptom Burden Post Hospitalisation With COPD
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|Pulmonary Disease, Obstructive|Emphysema|Chronic Bronchitis|Chronic Bronchitis With Airways Obstruction|Chronic Bronchitis With Acute Exacerbation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Thoracic Paravertebral Block With Methylene Blue Visual Confirmation for Postoperative Pain After VATS Lobectomy
Status: COMPLETED
Conditions: Post Operative Pain|Thoracic Cancer
Interventions: PROCEDURE: Paravertebral block with methylene blue|PROCEDURE: Thoracic Epidural Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Once Monthly Intravenous or Subcutaneous Mircera in Participants With Chronic Kidney Disease on Hemodialysis.
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Methoxy Polyethylene Glycol-epoetin Beta|DRUG: Epoetin Beta|DRUG: Darbepoetin Alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic (PK) and Pharmacodynamic (PD) Dose-ranging Phase II Study of Ticagrelor in Paediatric Patients With Sickle Cell Disease
Status: COMPLETED
Conditions: Investigation of Platelet Aggregation in Paediatric Patients With Sickle Cell Disease
Interventions: DRUG: Ticagrelor Dose 1a + Dose 2a|DRUG: Ticagrelor Dose 1b + Dose 2b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Hydrochlorothiazide and Metolazone in Combination With Furosemide in Congestive Heart Failure Patients
Status: UNKNOWN
Conditions: Congestive Heart Failure
Interventions: DRUG: metolazone or hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TRX4 Monoclonal Antibody in Type 1 Diabetes (T1 DM)
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Otelixizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Long-Term Immunogenicity in Children and Adolescents Boosted With a New Pediatric TBE Vaccine After Five Years
Status: COMPLETED
Conditions: Encephalitis, Tick-Borne
Interventions: PROCEDURE: blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability of NN9068 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: insulin degludec/liraglutide|DRUG: insulin degludec|DRUG: liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Floxin Otic Solution in the Treatment of Acute Otitis Media in Children
Status: COMPLETED
Conditions: Otitis Media
Interventions: DRUG: ofloxacin otic solution 0.3%
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Suction Circuit Flushing With Chlorhexidine Decreases Ventilator-Associated Pneumonia: A Quasi-experimental Study
Status: COMPLETED
Conditions: Ventilator Associated Pneumonia
Interventions: OTHER: Open tracheal suction system flushing with chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PIPAC for Peritoneal Metastases of Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Neoplasms|Peritoneal Neoplasms|Appendiceal Neoplasms|Peritoneal Carcinomatosis
Interventions: COMBINATION_PRODUCT: repetitive ePIPAC-OX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project POWER, Adapting Project SAFE: Reducing STD/HIV Risk in Women Prisoners
Status: COMPLETED
Conditions: HIV Infections
Interventions: BEHAVIORAL: Project POWER HIV Risk-reduction Intervention|BEHAVIORAL: NC DOC Standard of Care for STIs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Glucuronosyltransferase (UGT) Genetic Variation on Pharmacokinetics of Empagliflozin
Status: COMPLETED
Conditions: Pharmacogenomic|Pharmacokinetics
Interventions: DRUG: Empagliflozin 10 milligram
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Intrathecal Morphine vs. Intrathecal Morphine and Regional Anesthesia After Cesarean Section.
Status: SUSPENDED
Conditions: Post-operative Pain
Interventions: PROCEDURE: erector spinae plane block (ESP)|DRUG: Duramorph|DRUG: Ropivacaine|DRUG: Bupivacaine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Kangfuxin and Basic Fibroblast Growth Factor in Promoting the Healing of Donor Site
Status: UNKNOWN
Conditions: Fibroblast Growth Factors|Wound Healing
Interventions: DRUG: basic fibroblast growth factor|DRUG: Kangfuxin Liquid|DRUG: 0.9% Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 1630GCC: Zydelig Maintenance in B-Cell Non-Hodgkin's Lymphoma After Autologous Stem Cell Transplantation
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Hodgkin Lymphoma|Follicular Lymphoma|Indolent Lymphoma|B-cell Lymphoma|Transformed Lymphoma|Marginal Zone Lymphoma|Waldenstrom Macroglobulinemia|Small Lymphocytic Lymphoma|Lymphoplasmacytic Lymphoma
Interventions: DRUG: Zydelig
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D and Its Affect on Growth Rates and Bone Mineral Density Until Age 5
Status: UNKNOWN
Conditions: Vitamin D Deficiency
Interventions: DRUG: Vitamin D|OTHER: Placebo (for Vitamin D)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Direct Assessment of Microcirculation In Shock (DAMIS)
Status: COMPLETED
Conditions: Microcirculation|Intensive Care|Shock
Interventions: OTHER: Sublingual SDF-Measurement with communication and interpreting checklist to the treating physician|OTHER: Sublingual SDF-Measurement without communication and interpreting checklist to the treating physician
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Celecoxib/Oxaliplatin/Capecitabine for Gastric/Gastroesophageal Junction Carcinoma
Status: TERMINATED
Conditions: Gastric Carcinoma|Gastroesophageal Junction Carcinoma
Interventions: DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MYPROMS-ES02: Safety and Efficacy of Basiliximab, Cyclosporine Microemulsion and Enteric-coated Mycophenolate Sodium (EC-MPS) Versus EC-MPS and Steroid Therapy in Kidney Transplant Recipients Who Are Hepatitis C Positive
Status: TERMINATED
Conditions: De Novo Kidney Transplant
Interventions: DRUG: Enteric-coated Mycophenolate sodium (EC-MPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Early Rebiopsy to Identify Biomarkers of Tumor Cell Survival Following EGFR, ALK, ROS1 or BRAF TKI Therapy
Status: RECRUITING
Conditions: Non-Small Cell Carcinoma of Lung, TNM Stage 4|Non-Small Cell Lung Cancer|EGFR Gene Mutation|ALK Gene Mutation|ROSE Cluster 1|BRAF V600E
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Profiles of SR-T100 Gel on External Genital Warts/Condyloma Acuminate(EGWs)
Status: COMPLETED
Conditions: Condyloma Acuminata|Genital Warts|Condylomata Acuminata|Venereal Warts
Interventions: DRUG: Vehicle gel|DRUG: SR-T100 gel with 1.0 % SM|DRUG: SR-T100 gel with 2.3% SM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cost-effectiveness Study of a Lifestyle Change Program for the Treatment of OSA and Obesity: Hospital-Primary Care.
Status: COMPLETED
Conditions: Obstructive Sleep Apnea of Adult|Obesity|Lifestyle|Weight Loss
Interventions: BEHAVIORAL: Intensive weigh-loss program|BEHAVIORAL: Standard Dietary recommendations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study to Evaluate Surufatinib Plus Toripalimab in the Treatment of Advanced Neuroendocrine Carcinoma
Status: RECRUITING
Conditions: Advanced Neuroendocrine Carcinoma
Interventions: DRUG: Surufatinib plus Toripalimab|DRUG: 5-fluorouracil, Calcium folinate and Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of Bromhexine Given as Granules and Syrup in Healthy Volunteers (Clinical Phase I Study)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Bromihexine hydrochloride syrup|DRUG: Bromihexine hydrochloride granules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Engineered Neuroblastoma Cellular Immunotherapy (ENCIT)-01
Status: ACTIVE_NOT_RECRUITING
Conditions: Neuroblastoma|Ganglioneuroblastoma
Interventions: BIOLOGICAL: Patient Derived CD171 specific CAR T cells expressing EGFRt (2nd generation T cells)|BIOLOGICAL: Patient Derived CD171 specific CAR T cells expressing EGFRt (3rd generation T cells)|BIOLOGICAL: Patient Derived CD171 specific CAR T cells expressing EGFRt (long spacer 2nd generation T cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Block Versus Thoracic Paravertebral Block for Acute Thoracic Herpes Zoster
Status: UNKNOWN
Conditions: Acute Thoracic Herpes Zoster|Erector Spinae Plane Block|Thoracic Paravertebral Block|Pain Relief
Interventions: DRUG: Control Rx|PROCEDURE: Erector Spinae Block|PROCEDURE: Thoracic Paravertebral Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Intervention Effect of Stepped-care Models on Depression Symptoms During Pregnancy.
Status: NOT_YET_RECRUITING
Conditions: Perinatal Depression|Stepped Care
Interventions: COMBINATION_PRODUCT: "Mental Fitness Boot Camp - Advanced Counseling" Step-by-Step Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Reloading Prasugrel in a Patient Who Has Already Received a Loading Dose (LD) of Clopidogrel
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Prasugrel|DRUG: Prasugrel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Belatacept in Liver Transplant Recipients
Status: TERMINATED
Conditions: Immunosuppression in Solid Organ Transplant
Interventions: DRUG: Tacrolimus|DRUG: Basiliximab|DRUG: Belatacept More Intensive (MI)|DRUG: Belatacept Less Intensive (LI)|DRUG: Mycophenolate Mofetil (MMF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Dietary Nitrate Intake on Physical Performance of Middle-aged Women
Status: RECRUITING
Conditions: Postmenopausal; Menorrhagia|Physical Inactivity|Motor Activity
Interventions: DIETARY_SUPPLEMENT: Beetroot juice rich in nitrate|OTHER: Beetroot juice NO3 depleted
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjustment of Asthma Treatment in Children Based on an Indirect Hyperresponsiveness Test
Status: COMPLETED
Conditions: Asthma in Children
Interventions: OTHER: asthma treatment adjustment taking account on degree of bronchial hyperresponsiveness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Automatic Evaluation of the Severity of Gastric Intestinal Metaplasia With Pathology Artificial Intelligence Diagnosis System
Status: RECRUITING
Conditions: Gastric Intestinal Metaplasia|Artificial Intelligence|Pathology|Gastric Cancer
Interventions: DIAGNOSTIC_TEST: The diagnosis of Artificial Intelligence and pathologists
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Association Between Severe-to-profound Hearing Loss and the Balance Function of the Inner Ear
Status: ENROLLING_BY_INVITATION
Conditions: Hearing Loss, Sensorineural, Severe|Hearing Loss, Sensorineural, Profound|Vestibular Disorder
Interventions: DIAGNOSTIC_TEST: Caloric irrigation|DIAGNOSTIC_TEST: vHIT|DIAGNOSTIC_TEST: VEMP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p