pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Apical Compression Stitch - a New Option for LV Remodelling
Status: UNKNOWN
Conditions: Heart Failure|Left Ventrikular Remodelling|Left Ventricular Geometry
Interventions: PROCEDURE: LV Apex Compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Validation of the Clinical and Antimicrobial Effectiveness of a Clorexidine and Sodium DNA Based Mouthwash in Patients With Stage III and IV Periodontitis
Status: COMPLETED
Conditions: Periodontitis
Interventions: PROCEDURE: Non-surgical periodontal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effects of tDCS and VNS on Postoperative Analgesia
Status: NOT_YET_RECRUITING
Conditions: Acute Postoperative Pain
Interventions: DEVICE: Active transcranial direct current stimulation|DEVICE: Active vagus nerve stimulation|OTHER: Sham transcranial direct current stimulation|OTHER: Sham vagus nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Anti-CD22 CAR-T Cells Treating Leukemia Children
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia, in Relapse|Refractory Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: Autologous humanized anti-CD22 chimeric antigen receptor T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Imaging in Tobacco Smokers During a Quit Attempt
Status: COMPLETED
Conditions: Tobacco Use Disorder|Tobacco Smoking
Interventions: DRUG: [F18]-ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6-[18F]fluorodibenzo[b,d]thiophene 5,5-dioxide)|BEHAVIORAL: Contingency Management
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ingenol Mebutate 0.015% Gel in the Treatment of Actinic Keratoses (AK) on the Face and Scalp
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Ingenol Mebutate 0.015%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Study of Allogeneic Low Oxygen Mesenchymal Bone Marrow Cells in Subjects With Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: BIOLOGICAL: Stem cells|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Centralized IIS-based Reminder/Recall to Increase Childhood Influenza Vaccination Rates in New York State
Status: COMPLETED
Conditions: Reminder System for Influenza Vaccines
Interventions: BEHAVIORAL: 1 Notice|BEHAVIORAL: 2 Notices|BEHAVIORAL: 3 Notices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Antithrombin III in Infants With Cardiopulmonary Bypass (CPB)
Status: TERMINATED
Conditions: Congenital Heart Disease
Interventions: DRUG: Antithrombin III|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Nutrigenomic Models for the Personalized Treatment With Medical Foods in Obese People
Status: UNKNOWN
Conditions: Obesity|Dyslipidemia
Interventions: DIETARY_SUPPLEMENT: Administration of supplements containing methyl-donors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Infiltration of 2% Lidocaine With and Without Needle as Analgesia in Epidural Needle Insertion
Status: COMPLETED
Conditions: Epidural; Anesthesia, Headache|Analgesia
Interventions: DEVICE: Infiltration of 2% Lidocaine with Needle|DEVICE: Infiltration of 2% Lidocaine without Needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exploring the Effects of Sleep Patterns and Physical Activity on Asthma in Adolescents With Wrist-worn Smart Devices
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: Fitbit® Charge Heart Rate (HR) wristband
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Home-Based Assessment for Alzheimer Disease Prevention
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Alzheimer's Disease
Interventions: BEHAVIORAL: Mail and Live Phone|BEHAVIORAL: Interactive Voice Response (IVR)|BEHAVIORAL: Home-based Computer Kiosk|BEHAVIORAL: Traditional Evaluation Instruments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Retroperitoneal Tunneling Versus Dissection Technique During Sacrocolpopexy
Status: ACTIVE_NOT_RECRUITING
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: Tunneling Technique during RA SCP|PROCEDURE: Dissection Technique during RA SCP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Topical Radial Artery Vasodilation
Status: COMPLETED
Conditions: Cardiac Catheterization|Spasm
Interventions: DRUG: Nitroglycerin and lidocaine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pericapsular Nerve Block Versus Interscalene Nerve Block for Acute Pain Management in Shoulder Arthroscopy
Status: RECRUITING
Conditions: Pericapsular Nerve Block|Interscalene Nerve Block|Shoulder Arthroscopy
Interventions: PROCEDURE: The pericapsular nerve group|PROCEDURE: Interscalene brachial plexus block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Surgical Treatment of Progressive Scoliosis With "NEMOST" Growing Rod
Status: COMPLETED
Conditions: Progressive Scoliosis
Interventions: DEVICE: 2 NEMOST rods : bilateral vertebral-pelvic implantation|DEVICE: 1 NEMOST rod :unilateral vertebral-pelvic implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Immediate Effect of Postural Muscle's Vibrations on Gait in Chronic Vascular Hemiplegia
Status: COMPLETED
Conditions: Hemiplegia|Stroke
Interventions: OTHER: Gait analysis|OTHER: Kinematic gait analysis in lower limb|OTHER: Analysis of static posture|OTHER: Gait on treadmill|DEVICE: Muscle vibration stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Long- and Short-acting Diuretics in Congestive Heart Failure
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: DRUG: furosemide|DRUG: azosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Dose-response Study of Topically Delivered Halobetasol Propionate Ointment in Normal Skin in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ultravate® 0.05% ointment, single exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Zanzalintinib|DRUG: Zanzalintinib-matched Placebo|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neratinib With and Without Temsirolimus for Patients With HER2 Activating Mutations in Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: HER2-mutant Non-Small Cell Lung Cancer
Interventions: DRUG: neratinib|DRUG: temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cisplatin and Gemcitabine Plus Trastuzumab in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: Trastuzumab|DRUG: Cisplatin|DRUG: Gemcitabine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Depelestat in Acute Respiratory Distress Syndrome (ARDS) Patients
Status: COMPLETED
Conditions: Fibrosis|Lung Disease|Respiratory Disorders|Respiratory Distress Syndrome, Adult|Acute Respiratory Distress Syndrome|Pulmonary Fibrosis|Inflammation
Interventions: DRUG: EPI-hNE4|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Topical Steroids as Preemptive Therapy for EGFR Inhibitor-Induced Papulopustular Eruption
Status: TERMINATED
Conditions: Acneiform Rash|Papulopustular Eruption
Interventions: DRUG: Triamcinolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Endomicroscopy in Ulcerative Colitis
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: DEVICE: PENTAX EC-3870CIFK / EC-3870CILK confocal colonoscopes|DEVICE: PENTAX EC-3870CIFK / EC-3870CILK confocal colonoscopes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Simethicone on Postoperative Ileus in Patients Undergoing Colorectal Surgery
Status: COMPLETED
Conditions: Postoperative Ileus|Ileus
Interventions: DRUG: Simethicone|DRUG: Oral Suspending Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preeclampsia Educational Program Study (PrEPS)
Status: NOT_YET_RECRUITING
Conditions: Preeclampsia|Preeclampsia Severe|Preeclampsia Mild|Preeclampsia Postpartum
Interventions: OTHER: Illustration based application|OTHER: Text based application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluating the Effectiveness of Boceprevir, Pegylated-Interferon Alfa 2b and Ribavirin in Treating Hepatitis C Virus (HCV) Infection in Adults With HIV and HCV Infection
Status: COMPLETED
Conditions: HIV Infections|Hepatitis C
Interventions: DRUG: Pegylated-Interferon Alfa 2b (PEG-IFN)|DRUG: Ribavirin (RBV)|DRUG: Boceprevir (BOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recovery Roadmap Phase II Small Business Innovation Research Grant
Status: COMPLETED
Conditions: Mental Disorders|Behavior Disorders
Interventions: BEHAVIORAL: Recovery Roadmap (RR) Wave 1|BEHAVIORAL: Recovery Roadmap (RR) Wave 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Acute Effects of Different Stretching Methods in Individuals With Subacromial Impingement Syndrome
Status: COMPLETED
Conditions: Subacromial Impingement Syndrome|Glenohumeral Internal Rotation Deficit
Interventions: OTHER: Isolytic stretching group|OTHER: Static stretching group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BAR 502 in Healthy Subjects
Status: WITHDRAWN
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: BAR502|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Clinical Trial of Two Adjuvant Chemotherapy Regimens for Postoperative Gastric Cancer
Status: UNKNOWN
Conditions: Stomach Neoplasms
Interventions: DRUG: docetaxel plus oxaliplatin and capecitabine|DRUG: oxaliplatin plus capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double Blind Phase III Trial of Effects of Low Dose 13-Cisretinoic Acid on Prevention of Second Primaries in Stages I-II Head and Neck Cancer
Status: COMPLETED
Conditions: Stage I-II Head and Neck Cancer
Interventions: DRUG: 13-cis retinoic acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Auto-cross Linked Hyaluronic Acid Gel in the Prevention of Adhesion Reformation After Hysteroscopic Resection of Retained Products of Conception
Status: RECRUITING
Conditions: Retained Products of Conception
Interventions: OTHER: auto-crossed-linked hyaluronic acid gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fascial Manipulation Effect on Shoulder Range of Motion and Strength in Handball Players
Status: COMPLETED
Conditions: Connective Tissue Defect|Fascia; Anomaly
Interventions: PROCEDURE: Fascial Manipulation by Stecco method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Markers of Cardiovascular Risk in Patients With Premature Coronary Artery Disease and Treatment
Status: UNKNOWN
Conditions: Acute Coronary Syndrome|Premature Coronary Heart Disease|Lipoproteinemia|Inflammation|Genetic Polymorphisms
Interventions: DRUG: Alirocumab|DRUG: Evolocumab|DRUG: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Denervation Therapy for Resistant Hypertension in Type 2 Diabetes Mellitus
Status: TERMINATED
Conditions: Hypertension, Resistant|Diabetes Mellitus|Renal Denervation Therapy
Interventions: PROCEDURE: Renal denervation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patellar Tendinopathy - The Effect of Load Magnitude in Exercise-based Treatment
Status: COMPLETED
Conditions: Patellar Tendinopathy|Jumper's Knee
Interventions: OTHER: Heavy slow resistance training|OTHER: Moderate slow resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Ceftaroline Versus a Comparator in Pediatric Subjects With Complicated Skin Infections
Status: COMPLETED
Conditions: Infections, Pediatrics
Interventions: DRUG: Ceftaroline fosamil|DRUG: Vancomycin +/- Aztreonam or Cefazolin +/- Aztreonam|DRUG: Cephalexin or Clindamycin or Linezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Benefit of Complex Fractionated Atrial Electrograms Elimination in Atrial Fibrillation Ablation
Status: COMPLETED
Conditions: Atrial Fibrillation|Catheter Ablation
Interventions: PROCEDURE: Additional Complex Fractionated Electrograms ablation|PROCEDURE: Standard atrial fibrillation ablation procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Doxorubicin and Thermal Therapy in Treating Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: pegylated liposomal doxorubicin hydrochloride|PROCEDURE: hyperthermia treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decolonization of the Oropharynx, an Important and Neglected Reservoir of S. Aureus Colonization
Status: COMPLETED
Conditions: S. Aureus Oropharyngeal Colonization
Interventions: DRUG: Chlorhexidine gluconate|DRUG: Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Observational Trial Evaluating Elevated Factor VIII Related Labs as a Biomarker for Incomplete Relapse Recovery
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis|Relapse
Interventions: DIAGNOSTIC_TEST: blood tests drawn days 1, 8, 22 and 90 of the study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacovigilance in Gerontopsychiatric Patients
Status: TERMINATED
Conditions: Dementia|Depression|Schizophrenia|Psychosomatic Disorders|Anxiety Disorders
Interventions: DRUG: Phenobarbital|DRUG: Phenytoin|DRUG: Carbamazepine|DRUG: Oxcarbazepine|DRUG: Valproic Acid|DRUG: Lamotrigine|DRUG: Topiramate|DRUG: Gabapentin|DRUG: Levetiracetam|DRUG: Pregabalin|DRUG: Lacosamide|DRUG: Clonazepam|DRUG: Biperiden|DRUG: Levomepromazine|DRUG: Fluphenazine|DRUG: Perphenazine|DRUG: Perazine|DRUG: Thioridazine|DRUG: Haloperidol|DRUG: Melperone|DRUG: Pipamperone|DRUG: Bromperidol|DRUG: Benperidol|DRUG: Sertindole|DRUG: Ziprasidone|DRUG: Flupentixol|DRUG: Chlorprothixene|DRUG: Zuclopenthixol|DRUG: Fluspirilene|DRUG: Pimozide|DRUG: Clozapine|DRUG: Olanzapine|DRUG: Quetiapine|DRUG: Sulpiride|DRUG: Tiapride|DRUG: Amisulpride|DRUG: Prothipendyl|DRUG: Risperidone|DRUG: Aripiprazole|DRUG: Paliperidone|DRUG: Diazepam|DRUG: Oxazepam|DRUG: Lorazepam|DRUG: Bromazepam|DRUG: Clobazam|DRUG: Alprazolam|DRUG: Hydroxyzine|DRUG: Buspirone|DRUG: Chloral Hydrate|DRUG: Flurazepam|DRUG: Nitrazepam|DRUG: Triazolam|DRUG: Lormetazepam|DRUG: Temazepam|DRUG: Midazolam|DRUG: Brotizolam|DRUG: Zopiclone|DRUG: Zolpidem|DRUG: Zaleplon|DRUG: Melatonin|DRUG: Clomethiazole|DRUG: Diphenhydramine|DRUG: Promethazine|DRUG: Imipramine|DRUG: Clomipramine|DRUG: Opipramol|DRUG: Trimipramine|DRUG: Amitriptyline|DRUG: Nortriptyline|DRUG: Doxepin|DRUG: Maprotiline|DRUG: Amitriptyline oxide|DRUG: Fluoxetine|DRUG: Citalopram|DRUG: Paroxetine|DRUG: Sertraline|DRUG: Fluvoxamine|DRUG: Escitalopram|DRUG: Tranylcypromine|DRUG: Moclobemide|DRUG: Mianserin|DRUG: Trazodone|DRUG: Mirtazapine|DRUG: Bupropion|DRUG: Venlafaxine|DRUG: Reboxetine|DRUG: Duloxetine|DRUG: Agomelatine|DRUG: Pyritinol|DRUG: Piracetam|DRUG: Donepezil|DRUG: Rivastigmine|DRUG: Galantamine|DRUG: Memantine|DRUG: Nicergoline|DRUG: Acamprosate|DRUG: Lithium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Salmeterol-Fluticasone on Sleep in Patients With COPD
Status: WITHDRAWN
Conditions: Chronic Obstructive Pulmonary Disease|Sleep Disorders
Interventions: DRUG: salmeterol-fluticasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Time Course of Activity Signs at SD-OCT High Frequency Intravitreal Ranibizumab Treatment in CNV Due to AMD
Status: COMPLETED
Conditions: Choroidal Neovascularization|Age Related Macular Degeneration
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study of ESG401 for Locally Advanced or Metastatic HR+/HER2- Breast Cancer
Status: RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: ESG401|DRUG: Eribulin, capecitabine, gemcitabine or vinorelbine (Treatment of Physician's Choice)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cabazitaxel Versus Docetaxel Both With Prednisone in Patients With Metastatic Castration Resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Cabazitaxel (XRP6258)|DRUG: Docetaxel (XRP6976)|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluation the Safety and Efficacy of GR-MD-02 for the Treatment of Liver Fibrosis and Resultant Portal Hypertension in Patients With Nash Cirrhosis
Status: COMPLETED
Conditions: Hypertension, Portal
Interventions: DRUG: GR-MD-02|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Anti-Mineralocorticoid-Receptor Treatment in Anti-VEGF Refractory Neovascular Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: Spironolactone 50 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Bacteriuria, Antibiotic Susceptibility, and Treatment Response in Symptomatic Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Bacteriuria in Symptomatic Benign Prostate Hyperplasia|Antibiotic Susceptibility in Symptomatic Benign Prostate Hyperplasia|Treatment Response to Antibiotics in Symptomatic Benign Prostate Hyperplasia
Interventions: DRUG: Antibiotic therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Culture and Well-being: Art as Prescription Therapy ("Art on Prescription")
Status: RECRUITING
Conditions: Mental Health Issue|Anxiety Disorders|Depressive Disorder|Emotional Disorder|Schizophrenia|Autism
Interventions: OTHER: Arts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plasmodium Falciparum Genomic Intelligence in Mozambique
Status: COMPLETED
Conditions: Malaria,Falciparum|Malaria in Pregnancy|Malaria
Interventions: DIAGNOSTIC_TEST: LDH-based malaria rapid diagnostic test|DIAGNOSTIC_TEST: Malaria rapid diagnostic test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy Long-term Dietary Nitrate Consumption to Plasma Nitrite Conversion
Status: COMPLETED
Conditions: Cardiovascular Diseases in Old Age
Interventions: DIETARY_SUPPLEMENT: BRJ Nitrate|DIETARY_SUPPLEMENT: BRJ Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Rationalisation of Polypharmacy by the RASP-instrument and Discharge Counselling of Geriatric Inpatients
Status: WITHDRAWN
Conditions: Polypharmacy
Interventions: PROCEDURE: Medication review and discharge counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vitamin D as Treatment for Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: D-cure|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Ivacaftor in Subjects With Cystic Fibrosis Who Are Less Than 24 Months of Age and Have an Ivacaftor-Responsive CFTR Mutation
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: IVA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity
Status: ACTIVE_NOT_RECRUITING
Conditions: Spasticity|Cerebrovascular Accident|Multiple Sclerosis|Traumatic Brain Injury|Cervical Spinal Cord Injury|Cerebral Palsy
Interventions: DRUG: Phase 2; Low Dose MYOBLOC|DRUG: Phase 2; High Dose MYOBLOC|DRUG: Phase 2; Placebo|DRUG: Phase 3; MYOBLOC|DRUG: Phase 3; Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence and Safety of Vantobra and TOBI in Healthy Subjects
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Vantobra (tobramycin)|DRUG: TOBI (tobramycin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of AzaSite Versus Vigamox in the Tears of Healthy Volunteers
Status: COMPLETED
Conditions: Bacterial Infections|Eye Infections
Interventions: DRUG: AzaSite (azithromycin ophthalmic solution)|DRUG: Vigamox (moxifloxacin hydrochloride ophthalmic solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Stroke Prevention With Hydroxyurea Enabled Through Research and Education (SPHERE)
Status: ENROLLING_BY_INVITATION
Conditions: Sickle Cell Anemia in Children
Interventions: DRUG: Hydroxyurea|DIAGNOSTIC_TEST: Elevated Arm TCD Examination|DIAGNOSTIC_TEST: Normal Arm TCD Examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NewGait: A Low-Cost Rehabilitation System to Improve Post-Stroke Gait (Biomechanical Adaptations)
Status: RECRUITING
Conditions: Stroke
Interventions: OTHER: NewGait|OTHER: Control wearable limb orthotic device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhanced, EHR-facilitated Cancer Symptom Control Pragmatic Clinical Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Interview|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Using Exergame-based Program in Elders of Rural LTCF
Status: COMPLETED
Conditions: Sarcopenia|Frailty|Long Term Care Facility
Interventions: OTHER: Standard care plus plus Exergame-based multicomponent training program|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Central European Society for Anticancer Research (CESAR) Study of Paclitaxel Therapeutic Drug Monitoring
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Paclitaxel dosing according to SmPC|DRUG: Individualized pharmacokinetically driven paclitaxel dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Efficacy and Safety fo DEXTENZA, Sustained Release Dexamethasone 0.4 mg Insert(s) for the Treatment of Pain, Inflammation, and Cystoid Macular Edema Following 27 Gauge Vitrectomy With Internal Limiting Membrane Peel for the Treatment of Retinal Edema Associated With Macular Pucker.
Status: RECRUITING
Conditions: Vitrectomy|Macular Pucker|Retinal Edema
Interventions: DRUG: Dexamethasone Intracanalicular Insert, 0.4 mg|DRUG: Dexamethasone Intracanalicular Insert, 0.4 mg|DRUG: Prednisone acetate 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does a Soft Drink Mixture Improve Tolerance of Activated Charcoal in the Adult Poisoned Patient Without Affecting Efficacy
Status: COMPLETED
Conditions: Overdose
Interventions: DRUG: Activated Charcoal|DRUG: Activated Charcoal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug Interaction Study of SPD503 and Vyvanse Administered Alone and In Combination in Normal Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: SPD503|DRUG: VYVANSE|DRUG: SPD503 and VYVANSE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cyclophosphamide, Bortezomib, and Dexamethasone in Treating Patients With Newly Diagnosed Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: bortezomib|DRUG: cyclophosphamide|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incidence and Risk Factors for Surgical Site Infection After Intramedullary Nailing of Femoral and Tibial Fractures
Status: COMPLETED
Conditions: Fracture Fixation, Intramedullary|Surgical Wound Infection
Interventions: PROCEDURE: Intramedullary nailing for fracture fixation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mechanisms of Open and Hidden Placebo in Stroke Recovery
Status: RECRUITING
Conditions: Stroke|Hemiparesis
Interventions: DEVICE: Active rTMS|DEVICE: Sham rTMS|DIETARY_SUPPLEMENT: Open Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of B-GOS on GI Discomfort in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: B-GOS|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Exercise on Selected Anthropometric,Biochemical and Physiological Variables Among Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: OTHER: Aerobic exercise .|OTHER: Resistance exercise|OTHER: Aerobic and resistance exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Myfortic in High MELD Liver Transplantation
Status: WITHDRAWN
Conditions: High Model for End-Stage Liver Disease (MELD) Score
Interventions: DRUG: Everolimus, Myfortic and Tacrolimus|DRUG: Myfortic and Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Aerobic Exercise on an Elliptical Trainer Versus a Treadmill, in People with Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis (MS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing Two Different Myeloablation Therapies in Treating Young Patients Who Are Undergoing a Stem Cell Transplant for High-Risk Neuroblastoma
Status: COMPLETED
Conditions: Localized Resectable Neuroblastoma|Localized Unresectable Neuroblastoma|Recurrent Neuroblastoma|Regional Neuroblastoma|Stage 4 Neuroblastoma|Stage 4S Neuroblastoma
Interventions: PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Cyclophosphamide|DRUG: Doxorubicin Hydrochloride|DRUG: Etoposide|RADIATION: External Beam Radiation Therapy|BIOLOGICAL: Filgrastim|DRUG: Isotretinoin|OTHER: Laboratory Biomarker Analysis|DRUG: Melphalan|PROCEDURE: Peripheral Blood Stem Cell Transplantation|OTHER: Pharmacological Study|DRUG: Thiotepa|DRUG: Topotecan Hydrochloride|DRUG: Vincristine Sulfate Liposome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of First-line Treatment With Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Women With Persistent, Recurrent, or Metastatic Cervical Cancer (MK-3475-826/KEYNOTE-826)
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Paclitaxel|DRUG: Cisplatin|DRUG: Carboplatin|BIOLOGICAL: Bevacizumab|DRUG: Placebo to pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SAFIR02_Lung - Efficacy of Targeted Drugs Guided by Genomic Profiles in Metastatic NSCLC Patients
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer Metastatic
Interventions: DRUG: AZD2014|DRUG: AZD4547|DRUG: AZD5363|DRUG: AZD8931|DRUG: Selumetinib|DRUG: Vandetanib|DRUG: Standard maintenance for squamous NSCLC|DRUG: Pemetrexed|DRUG: Durvalumab|DRUG: savolitinib|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Hybrid Effectiveness-Implementation Trial of a School-Based Teen Marijuana Checkup
Status: COMPLETED
Conditions: Cannabis Use
Interventions: BEHAVIORAL: Teen Marijuana Check Up|OTHER: Treatment as Usual|BEHAVIORAL: Gold Standard Coaching|BEHAVIORAL: As Needed Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fractional CO2 Laser Treatment of Hypertrophic Scars
Status: TERMINATED
Conditions: Cicatrix, Hypertrophic
Interventions: DEVICE: Fractional CO2 laser treatment -
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: How Secreted-embryo-derived Trypsin Initiates, Maintains and Terminates Ca2+ Signals in Uterine Epithelial Cells
Status: COMPLETED
Conditions: Infertility|Infertility, Female|Aneuploidy
Interventions: OTHER: Exposure to culture media
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma, IDH-wildtype|Glioblastoma|Glioblastoma Multiforme|Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype|GBM
Interventions: DRUG: Eflornithine (Dose Level 1)|DRUG: Eflornithine (Dose Level 2)|DRUG: Eflornithine (Dose Level -1)|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebral Blood Flow and Metabolism During Hypoxia and Endotoxemia
Status: COMPLETED
Conditions: Hypoxia|Endotoxemia|Healthy
Interventions: PROCEDURE: Endotoxin infusion, Normobaric hypoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of PRO in Patients With Advanced Pancreatic or Biliary Tract Cancer (BetterEveryDay)
Status: RECRUITING
Conditions: Pancreatic Cancer|Lung Cancer, Nonsmall Cell
Interventions: OTHER: Supportive application with integrated weekly PRO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Feasibility of the Pray Until Something Happens (PUSH) Intervention-OUTPATIENT
Status: NOT_YET_RECRUITING
Conditions: Sickle Cell Disease|Stress|Pain
Interventions: BEHAVIORAL: Pray Until Something Happens (PUSH)|BEHAVIORAL: Self-monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab in Combination With 5-azacytidine in Childhood Relapsed/Refractory AML
Status: ACTIVE_NOT_RECRUITING
Conditions: AML, Childhood
Interventions: DRUG: Nivolumab|DRUG: 5-azacytidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemeprost Versus Dinoprostone in First Trimester Miscarriages
Status: RECRUITING
Conditions: Missed Abortion|Medical; Abortion, Fetus|Incomplete Abortion
Interventions: DRUG: Gemeprost 1 Mg Vaginal Pessary|DRUG: Dinoprostone 3 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Butylphthalide Soft Capsules in Patents With VCIND
Status: UNKNOWN
Conditions: Vascular Cognitive Impairment no Dementia
Interventions: DRUG: Butylphthalide Soft Capsules|DRUG: Placebo Butylphthalide Soft Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PASSIvation of Vulnerable Plaque With AZD5718 in AcuTe Coronary syndromE
Status: RECRUITING
Conditions: Acute Coronary Syndrome
Interventions: DRUG: AZD5718|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tailoring Treatment for B Cell Non-hodgkin's Lymphoma Based on PET Scan Results Mid Treatment
Status: UNKNOWN
Conditions: Lymphoma, Non-Hodgkin|Advanced Stage Diffuse Large B-Cell Non-Hodgkin's Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone|DRUG: Ondansetron|DRUG: Dexamethasone|DRUG: Diphenhydramine|DRUG: Acetaminophen|DRUG: Ifosfamide|DRUG: Mesna (IV)|DRUG: Mesna (oral)|DRUG: Carboplatin|DRUG: Etoposide|DRUG: Rituximab|DRUG: Ondansetron|DRUG: Dexamethasone|DRUG: Diphenhydramine|DRUG: Acetaminophen|OTHER: PET Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Utility of Pulse Pressure Variation to Predict the Fluid Responsiveness During Pneumoperitoneum and Reverse-Trendelenburg Position
Status: COMPLETED
Conditions: General Anesthesia
Interventions: PROCEDURE: Fluid infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Opioids on P2Y12 Receptor Inhibition in Patients With ST-Elevation Myocardial Infarction Who Are Pre-treated With Crushed Ticagrelor
Status: COMPLETED
Conditions: STEMI|STEMI - ST Elevation Myocardial Infarction
Interventions: DRUG: Paracetamol|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Response-Driven Adaptive Radiation Therapy for Patients With Locally Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: RADIATION: Response-driven Adaptive Radiation Therapy|DRUG: Carboplatin|DRUG: Paclitaxel|DEVICE: FDG-PET|DEVICE: V/Q SPECT|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assess Safety and Compare PK of New Oral hPTH(1-34) Tablet Formulations vs. EBP05 Tablets and Subcutaneous Forteo
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypoparathyroidism
Interventions: DRUG: EBP05|DRUG: Forteo 20 mg|DRUG: EBP11|DRUG: EBP22
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of IVA for Preventing Postvitrectomy Hemorrhage in PDR
Status: COMPLETED
Conditions: Proliferative Diabetic Retinopathy
Interventions: PROCEDURE: IVA injection before vitrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Low-voltage Areas Defragmentation in Sinus Rhythm for Radiofrequency Ablation of Persistent Atrial Fibrillation
Status: COMPLETED
Conditions: Cardiovascular Diseases|Atrial Fibrillation, Persistent
Interventions: PROCEDURE: Isolation of pulmonary veins|PROCEDURE: Ablation by radiofrequency of low-voltage areas
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase II Trial of Limited Surgery and Proton Therapy for Craniopharyngioma or Observation After Radical Resection
Status: ACTIVE_NOT_RECRUITING
Conditions: Craniopharyngioma
Interventions: PROCEDURE: Radical Surgery or Limited Surgery|DEVICE: Proton Therapy|DRUG: ^1^8F-fluorodeoxyglucose|DRUG: ^1^1C-methionine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-In-Human Intracoronary OCT-FLIm In Patients Undergoing PCI
Status: COMPLETED
Conditions: Atherosclerosis Coronary Artery With Angina Pectoris|Atheroscleroses, Coronary|Atherosclerotic Plaque|Thin-cap fIbroatheroma|Atherosclerosis
Interventions: DEVICE: Dual-modal OCT-FLIm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The InsuPad in Daily Life Study - Effect of Local Heating on Postprandial Glucose Excursions Using the InsuPad Device
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus With Diabetic Neuralgia
Interventions: DEVICE: InsuPad
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylaxis of Graft-versus-host Disease With Anti-CD25 Antibody in Patients Underwent HSCT
Status: NOT_YET_RECRUITING
Conditions: GVHD
Interventions: DRUG: CD25 treatment|DRUG: low-dose ATG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trivalent, Live, Cold Adapted Influenza Vaccine (CAIV-T) Against Inactivated Influenza Vaccine (TIV) in Children 6-59 Months of Age
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: Liquid CAIV-T
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: The Effects of Aspirin and Acetaminophen on the Stomach in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Acetaminophen - 4 grams per day + Placebo|DRUG: Aspirin - 325 mg per day + Placebo|DRUG: Acetaminophen 4 gram per day + Aspirin 325 mg per day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)
Status: RECRUITING
Conditions: Cardiac Arrest, Out-Of-Hospital|Hypothermia, Induced|Hypoxia-Ischemia, Brain
Interventions: DEVICE: Therapeutic Hypothermia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of N-acetylcysteine on the Craving Symptoms of Abstinent Hospitalized Patients With Cocaine Addiction
Status: RECRUITING
Conditions: Cocaine Addiction
Interventions: DRUG: N-acetylcysteine|DRUG: Lactose powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Companion Treatment Study for Patients With Moderate to Severe Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Isotretinoin|DRUG: Amzeeq 4% Topical Foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interscalene Block Alone Versus Interscalene Block With Erector Spinae Plane Block for Shoulder Arthroscopy Anesthesia
Status: COMPLETED
Conditions: Interscalene Block|Erector Spinae Plane Block|Shoulder Arthroscopy Anesthesia|Randomized Controlled Trial
Interventions: OTHER: interscalene with Erector spinae plane block group|OTHER: Interscalene group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Dairy Consumption on Glycemic Control, Body Weight and Cardiovascular Risk in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: OTHER: Full fat dairy|OTHER: Low fat dairy|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Intravenous Dexmedetomidine in Cesarean Section Under Spinal Anesthesia
Status: COMPLETED
Conditions: Cesarean Section Complications
Interventions: DRUG: Dexmedetomidine Injectable Product|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Glasdegib Renal Impairment Study
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Glasdegib single 100 mg dose in normal healthy subjects|DRUG: Glasdegib single 100 mg dose in moderate renal impairment subjects|DRUG: Glasdegib single 100 mg dose in severe renal impairment subjects
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cord Blood Fucosylation to Enhance Homing and Engraftment in Patients With Hematologic Malignancies
Status: COMPLETED
Conditions: Blood And Marrow Transplantation|Leukemia|Lymphoma|Transplantation Infection|Transplantation, Bone Marrow
Interventions: DRUG: Melphalan|DRUG: Fludarabine|DRUG: Mycophenolate mofetil|DRUG: Tacrolimus|PROCEDURE: Cord Blood Infusion|DRUG: Rituximab|DRUG: ATG|DRUG: Busulfan|DRUG: Clofarabine|RADIATION: Total Body Irradiation (TBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT