pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Cisplatin Plus Gemcitabine With or Without Paclitaxel in Treating Patients With Stage IV Urinary Tract Cancer
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter|Urethral Cancer
Interventions: DRUG: cisplatin|DRUG: gemcitabine hydrochloride|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Regimens of Dexamethasone in the Prevention of Hypersensitivity Reactions to Paclitaxel, a Pilot Study
Status: COMPLETED
Conditions: Prevention of Hypersensitivity Reactions to Paclitaxel
Interventions: DRUG: Dexamethasone per os|DRUG: Matching placebo for dexamethasone IV|DRUG: Dexamethasone IV|DRUG: Matching placebo for dexamethasone per os
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dyspnea Assessment in Hemodialysis Patients
Status: COMPLETED
Conditions: Dyspnea; Uremic|End Stage Renal Disease|Chronic Lung Disease|Chronic Heart Disease|Hemodialysis-Induced Symptom|Sodium Excess
Interventions: DIAGNOSTIC_TEST: Lung MRI|DIAGNOSTIC_TEST: Sodium MRI|DIAGNOSTIC_TEST: Chest CT|DIAGNOSTIC_TEST: Echocardiography|DIAGNOSTIC_TEST: Fractional Exhaled Nitric Oxide|DIAGNOSTIC_TEST: Pulmonary Function Tests|DIAGNOSTIC_TEST: Blood Sampling|DIAGNOSTIC_TEST: Six-Minute Walk Test|DIAGNOSTIC_TEST: Dyspnea Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Study of Sorafenib With Topotecan in Patients With Platinum-resistant Recurrent Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radial Extracorporeal Shock Wave Therapy Versus Platelet-rich Plasma Injection for Greater Trochanteric Pain Syndrome
Status: COMPLETED
Conditions: Gluteal Tendinopathy|Greater Trochanteric Pain Syndrome
Interventions: PROCEDURE: rESWT|PROCEDURE: PRP injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of Lactobacillus GG (LGG) in Children With Abdominal Pain
Status: COMPLETED
Conditions: Functional Abdominal Pain
Interventions: DIETARY_SUPPLEMENT: Lactobacillus GG (probiotic )|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Baby Act Trial (BAT): a Multimodal Lifestyle Intervention
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity in Childhood
Interventions: BEHAVIORAL: WIC+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Localization of Nonpalpable Breast Lesions
Status: COMPLETED
Conditions: Breast Cancer|Carcinoma in Situ
Interventions: PROCEDURE: Radioactive seed localization (RSL)|PROCEDURE: Wire-guided localization (WGL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin, Vitamin D, and Depression in Polycystic Ovary Syndrome (PCOS) Trial
Status: TERMINATED
Conditions: PCOS|Depression|Vitamin D Deficiency|Insulin Resistance
Interventions: DRUG: Metformin|DRUG: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of Liposomal Doxorubicin (Doxil)/Melphalan/Bortezomib (Velcade) in Relapsed/Refractory Multiple Myeloma
Status: WITHDRAWN
Conditions: Multiple Myeloma
Interventions: DRUG: Liposomal Doxorubicin/Melphalan/Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Lactobacillus Cultures on Iron Bioavailability.
Status: COMPLETED
Conditions: Low Iron Stores
Interventions: BEHAVIORAL: Active Lactobacillus plantarum 299v|DIETARY_SUPPLEMENT: Inactive Lactobacillus plantarum 299v
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial of Kryptonite for Prevention of Sternal Complications in High Risk Patients Undergoing Cardiac Surgery
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: Kryptonite|PROCEDURE: Conventional closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Microalgae as an Alternative Protein Source in Human Nutrition.
Status: COMPLETED
Conditions: Nutrition, Healthy
Interventions: DIETARY_SUPPLEMENT: Protein shake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Free Gingival Graft on Root Closure
Status: RECRUITING
Conditions: Gingival Recession|Lack of Keratinized Gingiva
Interventions: PROCEDURE: Free gingival graft placed apically|PROCEDURE: Free gingival graft placed coronally
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Short Film Video and Video-Based Education on Fear, Pain, and Satisfaction of Children Undergoing Day Surgery
Status: COMPLETED
Conditions: Day Surgery|Fear|Pain|Satisfaction|CHİLDREN
Interventions: OTHER: Group watching video|OTHER: Scheduled training group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TIME ASPIRIN: Chronotherapy With Aspirin for Reduction of Cardiovascular Disease
Status: TERMINATED
Conditions: Cardiovascular Diseases
Interventions: OTHER: placebo after awakening + aspirin before bedtime|OTHER: aspirin after awakening + placebo before bedtime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Acupuncture Treatment for Post-Stroke Depression and Anxiety Disorder.
Status: COMPLETED
Conditions: Post-stroke Depression|Anxiety Disorders
Interventions: PROCEDURE: Acupuncture Treatment|OTHER: Conventional Rehabilitation Programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tear Film Stability of DAILIES® AquaComfort Plus® Contact Lenses vs. MyDay® Daily Disposable Contact Lenses
Status: COMPLETED
Conditions: Refractive Error
Interventions: DEVICE: Nelfilcon A contact lenses|DEVICE: Stenfilcon A contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Efficacy and Safety of Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections
Status: COMPLETED
Conditions: Abscess|Wound Infection|Surgical Site Infection|Cellulitis
Interventions: DRUG: Dalbavancin|DRUG: Vancomycin / Linezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II/III Study Comparing Chemoradiotherapy With Radiotherapy in Elderly Patients With Esophageal or Esophagogastric Cancer - 3JECROG P-01
Status: COMPLETED
Conditions: Esophagus Cancer|Esophagogastric Junction Cancer|Radiotherapy; Complications|Chemoradiation
Interventions: RADIATION: SIB-IMRT|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clozapine Versus Haloperidol for Treating the First Episode of Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: Clozapine|DRUG: Haloperidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Nivolumab and Relatlimab in Cutaneous Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Cutaneous Squamous Cell Carcinoma
Interventions: DRUG: Nivolumab 240 mg / Relatlimab 80 mg in a fixed dose combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurolens and Contact Lens Discomfort
Status: NOT_YET_RECRUITING
Conditions: Contact Lens Discomfort
Interventions: DEVICE: Neurolens|DEVICE: Placebo spectacle lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Amblyopia Protocols Using a Dichoptic Gabor Videogame Program
Status: RECRUITING
Conditions: Amblyopia
Interventions: DEVICE: Visionary: computer exercises using dichoptic Gabor Patches and band-filtered noise masks|DEVICE: Patching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of (PN-152,243)/PN-196,444 in the Prevention of Thrombocytopenia
Status: COMPLETED
Conditions: Neoplasms|Thrombocytopenia|Multiple Myeloma|Lymphoma, Malignant
Interventions: DRUG: (PN-152,243)/PN-196,444
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Blinatumomab in Pediatric B-cell Acute Lymphoblastic Leukemia (ALL) With Minimal Residual Disease (MRD)
Status: RECRUITING
Conditions: Pediatric ALL, B Cell|Minimal Residual Disease
Interventions: DRUG: Blinatumomab for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cacao Consumption in Patients With Insulin Resistance
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: Cacao 70%|DIETARY_SUPPLEMENT: White chocolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Pharmacokinetic Study of a Prolonged-release Formulation of St. John's Wort Extract Ze 117
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: St. John's wort prolonged-release tablet 500 mg|DRUG: St. John's wort film coated tablets 250 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Linking Infectious and Narcology Care-Part II
Status: COMPLETED
Conditions: HIV Infection|Drug Use
Interventions: OTHER: Rapid ART initiation|DRUG: Pharmacotherapy for opioid use disorder|BEHAVIORAL: Strengths-based HIV case management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Adaptive Radiation in Anal Cancer
Status: RECRUITING
Conditions: Anal Squamous Cell Carcinoma
Interventions: RADIATION: Artificial Intelligence Guided Daily Radiotherapy Treatment Planning and Delivery|DRUG: Mitomycin-C|DRUG: 5-Fluorouracil|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Stress Adenosine Cardiac Magnetic Resonance (MR) Comparison With Single Photon Emission Computed Tomography (SPECT) Imaging
Status: UNKNOWN
Conditions: Coronary Artery Disease|Cardiac Perfusion
Interventions: PROCEDURE: SPECT Imaging|PROCEDURE: Stress Adenosine CMR
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of a Collagen Hydrolysate on Postprandial Blood Glucose Profile in Prediabetic and Healthy Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy|Prediabetic State
Interventions: DIETARY_SUPPLEMENT: Collagen hydrolysate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bispectral Index (BIS) Versus Electronic Alerts in the Prevention of Anesthesia Awareness: the Michigan Awareness Control Study
Status: COMPLETED
Conditions: Awareness During General Anesthesia
Interventions: DEVICE: Bispectral Index Monitor|DEVICE: Electronic MAC alert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Abdominal Compression in Orthostatic Hypotension
Status: COMPLETED
Conditions: Autonomic Failure|Orthostatic Hypotension
Interventions: OTHER: Abdominal binder|OTHER: No abdominal binder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prosthesis and Surgery Guide System for Personalized Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Personalized TKA prosthesis|DEVICE: Zimmer NexGen prostheses
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Monolithic Zirconia Crowns for Single Implants in the Molar Region: a Multicenter Clinical Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Implant-supported Single Crowns
Interventions: DEVICE: ZrO2 (Straumann CARES)|DEVICE: PFM crown (Straumann Gold)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Pharmacokinetic Bioequivalence of Budesonide and Albuterol With an Alternate Propellant Compared to Current Propellant.
Status: COMPLETED
Conditions: Heathy Participants
Interventions: DRUG: Treatment A (BDA MDI HFO)|DRUG: Treatment B (BDA MDI HFA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: FIH Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy
Status: RECRUITING
Conditions: Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis
Interventions: BIOLOGICAL: NRTX-1001|PROCEDURE: Sham Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant and Adjuvant Targeted Treatment in NSCLC With BRAF V600 or MET Exon 14 Mutations
Status: NOT_YET_RECRUITING
Conditions: NSCLC|BRAF V600 Mutation|MET Exon 14 Mutation
Interventions: DRUG: Dabrafenib + Trametinib|DRUG: Capmatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trivalent Ganglioside Vaccine With Immunological Adjuvant or Immunological Adjuvant Alone in Metastatic Sarcoma Patients Who Are Rendered Disease Free
Status: COMPLETED
Conditions: Sarcoma
Interventions: BIOLOGICAL: Trivalent ganglioside vaccine|BIOLOGICAL: OPT-821
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Dapagliflozin and Metformin on Vascular Function in Newly-Diagnosed Treatment-Naive Type 2 Diabetes
Status: UNKNOWN
Conditions: Diabetes
Interventions: DRUG: Dapagliflozin|DRUG: MetFORMIN 500 Mg Oral Tablet|DRUG: Dapagliflozin / metFORMIN Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Avastin (Bevacizumab) Plus Taxane-Based Therapy in Patients With Locally Recurrent or Metastatic Breast Cancer.
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: bevacizumab [Avastin]|DRUG: Taxane-based chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Irritation by Two Facial Gels Applied to Opposite Sides of the Face
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Tretinoin gel|DRUG: Adapalene and Benzoyl peroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pulsed Radiofrequency One or Three Nerves for Chronic Shoulder Pain. A Prospective, Randomized, Double-blind Study
Status: RECRUITING
Conditions: Chronic Shoulder Pain
Interventions: PROCEDURE: Pulsed radiofrequency neuromodulation of the suprascapular nerve only|PROCEDURE: Pulsed radiofrequency neuromodulation of the suprascapular, axillary, and articular branch of the lateral pectoral nerves
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Learn How the Cancer Vaccine BNT116 in Combination With Cemiplimab Works and How Safe the Combination is in Adults With Advanced Non-small Cell Lung Cancer (EMPOWERVAX Lung 1)
Status: RECRUITING
Conditions: Advanced Non-Small Cell Lung Cancer
Interventions: DRUG: BNT116|DRUG: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spinal Versus General Anesthesia With Popliteal and Adductor Canal Blocks for Ambulatory Foot and Ankle Surgery.
Status: COMPLETED
Conditions: Nerve Block|General Anesthesia|Spinal Anesthesia|Pain|Postoperative Nausea and Vomiting
Interventions: PROCEDURE: 25 mL of 0.25% bupivacaine plus 2 mg preservative-free (PF) dexamethasone / 30 ml for popliteal nerve block|PROCEDURE: 10 mL of 0.25% bupivacaine plus 2 mg preservative-free (PF) dexamethasone / 30 ml for adductor canal nerve block|DRUG: Midazolam, 2-5 mg IV + Glycopyrrolate, 0.1 mg IV + Ketamine, 10-20 mg + propofol as needed|PROCEDURE: 45-60 mg of 1.5% mepivacaine for spinal anesthesia|PROCEDURE: LMA insertion + titrated propofol infusion + sevoflurane + ketamine 10 mg/hr for general anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Nueva Ecija Cardiovascular Risk Experiment
Status: UNKNOWN
Conditions: Cardiovascular Diseases|Cardiovascular Risk Factor
Interventions: BEHAVIORAL: Information on CVD Risk|BEHAVIORAL: Lottery Incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Research on Early Diagnosis and Clinical Transformation of Nuclide Probe Based on Bioorthogonal-gastric Cancer Mucin Target Visualization
Status: RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: 18F-FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Comparison Study Of Two Different Techniques For Identifying The Epidural Space In Parturients In Labour
Status: COMPLETED
Conditions: Labouring Parturients Requiring/Requesting Epidural Analgesia as Part of Their Peri-partum Care
Interventions: DEVICE: Epidrum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Kinesio Taping in Subjects With Myofascial Pain Syndrome: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Myofascial Pain Syndrome
Interventions: OTHER: Manual pressure release|OTHER: Kinesio tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Direct Comparison of TG and WFO LASIK
Status: COMPLETED
Conditions: Keratomileusis, Laser In Situ|Contrast Sensitivity
Interventions: DEVICE: Topoguided LASIK|DEVICE: Wavefront optimized LASIK
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Lumiracoxib in Relieving Moderate to Severe Post-dental Surgery Pain, Compared to Both Placebo and Celecoxib
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Lumiracoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Kinerase® for Treatment of Cutaneous Facial Photodamage
Status: COMPLETED
Conditions: Skin Roughness|Mottling|Blotchiness|Pigmentation|Fine Wrinkles
Interventions: OTHER: Kinerase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of ATHENA CAR-T in Subjects With Systemic Lupus Erythematosus
Status: NOT_YET_RECRUITING
Conditions: Lupus Erythematosus, Systemic
Interventions: BIOLOGICAL: ATHENA CAR-T|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Supraclavicular and Infraclavicular Subclavian vs Catheterization in Pediatric
Status: COMPLETED
Conditions: Ultrasound Guided|Supraclavicular|Infraclavicular|Subclavian|Venous Catheterization|Pediatric
Interventions: DEVICE: Ultrasound-guided supraclavicular approach|DEVICE: Ultrasound-guided infraclavicular approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: KK-LC-1 TCR-T Cell Therapy for Gastric, Breast, Cervical, and Lung Cancer
Status: RECRUITING
Conditions: Gastric Cancer|Breast Cancer|Cervical Cancer|Lung Cancer
Interventions: BIOLOGICAL: KK-LC-1 TCR-T cells|DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Open Study of Metronomic Oral Vinorelbine in Combination With Aromatase Inhibitors for the Treatment of Postmenopausal Women With Hormone Receptor Positive,HER2-negative, Advanced Breast Cancer Who Received no Prior Therapy for Advanced Disease
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Letrozole|DRUG: Anastrozole|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo-Controlled Double-Blind Crossover Comparative Study of KW-6500
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: KW-6500|DRUG: KW-6500 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Safety and Tolerability of Macitentan in Subjects With Combined Pre- and Post-capillary Pulmonary Hypertension (CpcPH) Due to Left Ventricular Dysfunction
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Macitentan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Study of Phacoemulsification by the Enlarged Internal Incision and the Regular 2.2mm Incision
Status: UNKNOWN
Conditions: Cataract
Interventions: PROCEDURE: enlarged internal incision|PROCEDURE: regular 2.2mm incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Control Study of Immunotherapy and Concurrent Chemoradiotherapy in Patients With Esophageal Cancer Recurrence
Status: UNKNOWN
Conditions: Esophageal Malignant Neoplasm, Local Recurrence
Interventions: DRUG: Procedural death 1|DRUG: Capecitabine|RADIATION: Radiotherapy|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Trial for Post-Menopausal Women With Newly Diagnosed Operable Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Letrozole in combination with Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Inhibitory Kinesio Taping Application on Spasticity, Stretch Reflex and Motor Neuron Activity
Status: COMPLETED
Conditions: Muscle Physiology
Interventions: PROCEDURE: kinesio taping method|PROCEDURE: Sham kinesio taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Reducing Circulating Sphingolipid Levels to Optimise Cardiometabolic Health - The SphingoFIT Trial
Status: RECRUITING
Conditions: Overweight and Obesity|Dyslipidemias|Blood Pressure|Cardiovascular Diseases|Metabolic Disease
Interventions: OTHER: 8-week HIIT programme|OTHER: Physical activity recommendation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Dexmedetomidine on Levels of Plasma Inflammatory Factor in Asthma Patients Undergoing General Anesthesia
Status: UNKNOWN
Conditions: Anesthesia|Asthma
Interventions: DRUG: Anesthesia induction|DRUG: Anesthesia maintenance|DRUG: Assisted anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: An Efficacy and Safety Study of Beloranib in Obese Subjects With Type 2 Diabetes Mellitus
Status: TERMINATED
Conditions: Obesity|Type 2 Diabetes
Interventions: DRUG: ZGN-440 for Injectable Suspension|DRUG: ZGN-440 Placebo for Injectable Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Helping Children's Centres to Enhance Home Safety
Status: COMPLETED
Conditions: Burns|Smoke Inhalation Injury
Interventions: BEHAVIORAL: Injury Prevention Briefing Plus facilitation|BEHAVIORAL: Injury Prevention Briefing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Point-of-care Tests for Vaginal Discharge in Nepal
Status: RECRUITING
Conditions: Vaginal Discharge|Sexually Transmitted Diseases
Interventions: DIAGNOSTIC_TEST: Health care practitioner is informed of POCT results for CT and NG|DIAGNOSTIC_TEST: Health care practitioner is informed about POCT result for TV and BV|OTHER: addressing psycholsocial problems
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Investigating the Effect of Food on the Bioavailability of a Fixed Dose Combination of Obicetrapib and Ezetimibe
Status: COMPLETED
Conditions: Healthy Volunteer Study
Interventions: DRUG: Fixed-Dose Combination (FDC) Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HEALTHY (Health Education Adolescent Leadership Training to Help Youth) Leaders
Status: COMPLETED
Conditions: Stress
Interventions: BEHAVIORAL: Mindfulness based stress reduction|BEHAVIORAL: only pre and post evaluation measures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Trial of Adjuvant Therapy After Hepatocarcinoma Resection Based on Folate Receptor-positive Circulating Tumor Cells
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: FOLFOX4(infusional fluorouracil [FU], leucovorin [LV], and oxaliplatin [OXA]).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Posterior Sacroiliac Ligament Corticosteroid Injection in Pregnancy-Related Pelvic Girdle Pain
Status: TERMINATED
Conditions: Pelvic Girdle Pain
Interventions: DRUG: Corticosteroid|DRUG: Placebo Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RCT: Titanium vs FCZ vs Zirconia Framework
Status: RECRUITING
Conditions: Dental Prosthesis Failure
Interventions: DEVICE: High-translucent monolithic zirconia Bridge|DEVICE: Zirconium oxide ceramics Framework|DEVICE: Metal-ceramic Framework
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis
Status: COMPLETED
Conditions: Low Back Pain|Leg Pain|Spondylolisthesis|Lumbar Spinal Stenosis
Interventions: DEVICE: "TOPS System" - Total Posterior Arthroplasty Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Compare the Effects of Immediate-release Tacrolimus and Astagraf XL on Donor-Specific Antibody (DSA) Formation and the Development of Immune Activation (IA) in de Novo Kidney Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: Tacrolimus|DRUG: Tacrolimus immediate release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Physiotherapy on Dysfunctional Breathing in Children and Adolescents With and Without Asthma
Status: RECRUITING
Conditions: Dysfunctional Breathing|Asthma in Children|Asthma
Interventions: OTHER: Physiotherapy|OTHER: standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Naloxone Pharmacokinetics
Status: COMPLETED
Conditions: Opioid-use Disorder
Interventions: DRUG: Naloxone|DEVICE: Mucosal atomization device and syringe|DEVICE: Narcan|DEVICE: Intramuscular Auto Injector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CB-183,315 in Participants With Clostridium Difficile Infection
Status: COMPLETED
Conditions: Clostridium Difficile Infection|Diarrhea
Interventions: DRUG: CB-183,315|DRUG: Placebo|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation and Combination Immunotherapy for Melanoma
Status: COMPLETED
Conditions: Metastatic Melanoma
Interventions: DRUG: Aldesleukin: All Patients|DRUG: Nivolumab: Cohort 1 (Cutaneous)|DRUG: Nivolumab: Cohort 2 (Ocular)|DRUG: Ipilimumab: Cohort 2 (Ocular)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient's Expectations, Preferences, Experiences Before, During and After the Treatment With Invisalign® Aligners
Status: RECRUITING
Conditions: Surveys and Questionnaires|Quality of Life|Orthodontics|Orthodontic Appliances
Interventions: DEVICE: IInvisalign® Aligners
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neuromuscular-Blocking Agents and Hypoxemia During Intubation in Infants (ROC-HYPOX)
Status: RECRUITING
Conditions: Hypoxemia
Interventions: DRUG: Rocuronium|OTHER: Sodium chloride 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Improving Sleep of Children With Neurodevelopmental Disorders: Pulsed Current Stimulation Versus Melatonin
Status: RECRUITING
Conditions: Insomnia|Neurodevelopmental Disorders
Interventions: DEVICE: transcranial pulsed current stimulation|DRUG: Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Olmesartan Medoxomil in Stage 1 and 2 Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: olmesartan medoxomil + hydrochlorothiazide, if necessary + amlodipine, if necessary
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A New Method for Deltoid Ruptures: Gap Sign
Status: RECRUITING
Conditions: Ankle Fractures|Ligament Rupture|Ligament Injury
Interventions: DIAGNOSTIC_TEST: Deltoid Gap Sign
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase II Randomized-registry Embedded Study of Lymphoscintigraphy for Oropharyngeal Neoplasms to Enable Risk-adapted Nodal Guidance for Robotic Surgery and/or Radiotherapy (LONE-RANGR2)
Status: RECRUITING
Conditions: Oropharyngeal Neoplasms|Robotic Surgery and/or Radiotherapy|Lymphoscintigraphy
Interventions: RADIATION: Arm 1- Ipsilateral
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional and Self-reported Outcomes in Participants With a History of Musculoskeletal Knee Injury
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injury|Anterior Cruciate Ligament Rupture
Interventions: OTHER: Exercise Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Timing of Euploid Day 6 Blastocyst Transfer in Frozen HRT Cycles, Day 6 or Day 7 of Progesterone Administration.
Status: RECRUITING
Conditions: Infertility|Fertility Issues|Infertility, Female
Interventions: DIAGNOSTIC_TEST: Transvaginal ultrasound|DIAGNOSTIC_TEST: Serum LH, E2, P4|DRUG: Estradiol Valerate 2 MG|DRUG: Progesterone 100 Mg Vaginal Insert|DIAGNOSTIC_TEST: Serum P4 day of ET|PROCEDURE: Embryo transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of NRD135S.E1 in Peripheral Neuropathic Pain in Diabetic Patients
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathic Pain
Interventions: DRUG: NRD135S.E1|DRUG: Placebo to match NRD135S.E1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Pre- and Post-Change Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: DRUG: Teclistamab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surufatinib Combined With Serplulimab and Standard Chemotherapy as First-line Treatment in Advanced Solid Tumors With Neuroendocrine Differentiation
Status: NOT_YET_RECRUITING
Conditions: ESCC|Biliary Tract Cancer|Gastric Cancer|Pancreas Cancer
Interventions: DRUG: Surufatinib|DRUG: Serplulimab|DRUG: standard chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lendexal in Patients With Primary Systemic Amyloidosis (AL) Newly Diagnosed
Status: COMPLETED
Conditions: Primary Systemic Amyloidosis
Interventions: DRUG: Lenalidomide|DRUG: Cyclophosphamide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Naproxen sodium 440 mg / DPH 50 mg (BAY98-7111)|DRUG: Naproxen sodium 220 mg / DPH 50 mg (BAY98-7111)|DRUG: Naproxen sodium 440 mg (BAYH6689)|DRUG: DPH 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of PRO-148 Ophthalmic Solution Versus SYSTANE® in the Treatment of Patients With Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: PRO-148 Ophthalmic Solution|DRUG: Active Comparator: SYSTANE ® Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Osteopathic Treatment on Pulmonary Function After Coronary Artery Bypass Graft Surgery
Status: TERMINATED
Conditions: Mechanical Complication of Coronary Artery Bypass Graft|Respiratory Depression|Pain|Quality of Life
Interventions: OTHER: Usual care|OTHER: Osteopathic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Application of TMS Coupled With VR for Slowing the Rate of Cognitive Decline in Patients With Alzheimer's Disease
Status: WITHDRAWN
Conditions: Alzheimer Disease
Interventions: DEVICE: TMS stimulation with X-Torp task|DEVICE: TMS-Stimulation with MindMotion Go|DEVICE: TMS-Sham with X-Torp task|DEVICE: TMS-Sham with MindMotion Go
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Velcade™ in Subjects With Relapsed or Refractory Follicular B-Cell Lymphoma
Status: TERMINATED
Conditions: Follicular Lymphoma
Interventions: DRUG: Bortezomib|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of Lenalidomide in Combination With Cetuximab in Pre-treated Patients With KRAS Mutant Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: cetuximab|DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-marketing Surveillance for the Clinical Safety and Effectiveness of Eribulin Mesylate in Patients With Inoperable or Recurrent Breast Cancer (Study HAL01S)
Status: COMPLETED
Conditions: Inoperable or Recurrent Breast Cancer
Interventions: DRUG: Eribulin Mesylate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: EXCimEr Laser for Long lENgTh Lesions in Below-The-Knee Arteries Study
Status: TERMINATED
Conditions: Peripheral Arterial Occlusive Disease
Interventions: DEVICE: Spectranetics Turbo elite™ excimer laser catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Late Acquired Malaposition and Different Polymers
Status: COMPLETED
Conditions: Late Acquired Stent Malaposition
Interventions: PROCEDURE: Everolimus-Eluting Stent (EES)|PROCEDURE: Zotarolimus-Eluting-Stent (ZES)|PROCEDURE: Biolimus-Eluting-Stent (BES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized Feedback Programs for College Students
Status: COMPLETED
Conditions: Alcohol Use, Unspecified
Interventions: BEHAVIORAL: Resources|BEHAVIORAL: Personalized Feedback Program (PFP)|BEHAVIORAL: Substance Use Feedback Program (BMI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: To Evaluate the Use of Radiomics to Classify Between Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease
Status: COMPLETED
Conditions: Interstitial Lung Disease|Idiopathic Pulmonary Fibrosis|Usual Interstitial Pneumonia
Interventions: DIAGNOSTIC_TEST: radiomics
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste
Status: COMPLETED
Conditions: Pulp Necrosis
Interventions: DRUG: Double Antibiotic Paste|DRUG: Triple Antibiotic Paste|DRUG: Mineral Trioxide Aggregate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ET-01 in Subjects With Lateral Canthal Lines, LCL-207
Status: COMPLETED
Conditions: Lateral Canthal Lines|Crow's Feet
Interventions: BIOLOGICAL: Vehicle|BIOLOGICAL: botulinum toxin, Type A|BIOLOGICAL: botulinum toxin, Type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coverage of Requirements After Consumption of a Nutritional Formula in Patients With Chewing/Swallowing Problems.
Status: COMPLETED
Conditions: Deglutition Disorders|Nutritional Deficiency|Chew Problems|Swallowing Disorder
Interventions: OTHER: Control Group (education, guidelines, recommendations)|OTHER: Experimental Group (education, guidelines, 2 pckts diet, recommendations)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Virtual Implicit Bias Reduction and Neutralization Training (VIBRANT)
Status: RECRUITING
Conditions: Implicit Bias
Interventions: BEHAVIORAL: Brief Online Training (BOLT) for measurement-based care (MBC)|BEHAVIORAL: Virtual Implicit Bias Reduction and Neutralization Training (VIBRANT)|BEHAVIORAL: Live Post-Training Consultation|BEHAVIORAL: Asynchronous Discussion Board
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: To Study Generic Calcipotriene and Betamethasone Dipropionate Topical Foam, 0.005%/0.064%, in the Treatment of Psoriasis Vulgaris (Plaque Psoriasis).
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: Calcipotriene/ betamethasone dipropionate topical foam, 0.005%/0.064%|DRUG: Enstilar® foam (LEO Pharma Inc.)|OTHER: Placebo of Calcipotriene/ betamethasone dipropionate topical foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TQB2916 Injection Combined With Chemotherapy or Penpulimab Injection in the Treatment of Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Soft Tissue Sarcoma|Melanoma
Interventions: DRUG: TQB2916 injection + doxorubicin hydrochloride for injection|DRUG: TQB2916 injection+penpulimab injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CBT Versus a Return to Work Intervention for Patients With Common Mental Illness in Primary Care
Status: COMPLETED
Conditions: Anxiety Disorders|Major Depression|Stress Disorders|Primary Insomnia
Interventions: BEHAVIORAL: Cognitive behavior therapy|BEHAVIORAL: Return to work
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MGD020 Alone or Combined With MGD014 in Persons With HIV-1 on Antiretroviral Therapy
Status: COMPLETED
Conditions: Human Immunodeficiency Virus I Infection|Immunodeficiency Virus Type 1, Human|Human Immunodeficiency Virus Type 1
Interventions: BIOLOGICAL: MGD020|BIOLOGICAL: MGD014
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of PRO 140 in HIV Uninfected Male Volunteers
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: PRO 140
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tunnel With and Without Intramucosal Vertical Incisions
Status: COMPLETED
Conditions: Gingival Recession
Interventions: PROCEDURE: Tunnel + AlloDerm®|PROCEDURE: Tunnel + AlloDerm® + Verticals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: staRt: Enhancing Speech Treatment With Smartphone-delivered Biofeedback
Status: COMPLETED
Conditions: Speech Sound Disorder
Interventions: BEHAVIORAL: Traditional articulation treatment|BEHAVIORAL: Visual-acoustic biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of a Therapeutic Education Program of Patient on the Evolution of the Cardiovascular Chronic Disease
Status: COMPLETED
Conditions: Stroke|Myocardial Infarction
Interventions: OTHER: Optimized conventional therapy alone|BEHAVIORAL: Optimized conventional therapy with therapeutic education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION