pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluation of Post-operative Discomforts in Children After Extraction of Temporary Teeth
Status: COMPLETED
Conditions: Post-extraction Pain (PEP)|Post-extraction Lip or Cheek Biting Injury (PEBI)|Post-extraction Bleeding (PEB)|Tooth Removal
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Minitransplants With HLA-matched Donors : Comparison Between 2 GVHD Prophylaxis Regimens
Status: ACTIVE_NOT_RECRUITING
Conditions: Graft-Versus-Host Disease|Hematological Malignancies
Interventions: DRUG: Mycophenolate mofetil|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combined CO2 Fractional Laser With Bimatoprost 0.03% Treatment of Alopecia Areata
Status: COMPLETED
Conditions: Alopecia Areata
Interventions: DRUG: Bimatoprost 0.03% solution|DEVICE: CO2 fractional laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Telerehabilitation Program in Ankle Sprain
Status: COMPLETED
Conditions: Ankle Sprain|Ankle Sprain 1St Degree|Ankle Sprain 2Nd Degree
Interventions: OTHER: telerehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor
Status: WITHDRAWN
Conditions: Brain and Central Nervous System Tumors|Neuroblastoma|Retinoblastoma|Sarcoma
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: leucovorin calcium|DRUG: methotrexate|DRUG: temozolomide|DRUG: thiotepa|DRUG: vincristine sulfate|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Different Ovarian Stimulation Protocols on Endometrial Receptivity
Status: COMPLETED
Conditions: Infertility, Female|Endometrial Diseases
Interventions: DRUG: CFA|DRUG: rFSH|PROCEDURE: Fixed daily rFSH dosing protocol of 200-300 IU|PROCEDURE: Step-down daily rFSH dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy, Safety and Tolerability of AFQ056 in Patients With Huntington's Disease in Reducing Chorea
Status: TERMINATED
Conditions: Huntington's Disease|Chorea
Interventions: DRUG: AFQ056|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Food Pharmacy at Oregon Health & Science University (OHSU) Knight Cardiovascular Institute (KCVI)
Status: COMPLETED
Conditions: Hyperlipidemias
Interventions: DIETARY_SUPPLEMENT: Fruit and vegetable deliveries
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study Of a Micro-Implantable Pulse Generator For The Treatment of Peripheral Neuropathic Pain
Status: RECRUITING
Conditions: Peripheral Neuralgia|Chronic Pain
Interventions: DEVICE: Nalu Neurostimulation System for PNS|OTHER: conventional medical management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy and Safety in Chinese Patients With Late Onset Pompe Disease With Alglucosidase Alfa Treatmen
Status: COMPLETED
Conditions: Pompe's Disease
Interventions: DRUG: ALGLUCOSIDASE ALFA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dermal Safety Study to Evaluate the Sensitizing Potential of Abametapir Lotion
Status: COMPLETED
Conditions: Head Lice
Interventions: DRUG: Abametapir Lotion 0.74% w/w|OTHER: 0.1% sodium lauryl sulfate|OTHER: saline 0.9%|OTHER: Vehicle Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-study to Investigate the Safety and Efficacy of Replenine®-VF in Haemophilia B Subjects Undergoing Surgery
Status: COMPLETED
Conditions: Haemophilia B
Interventions: BIOLOGICAL: Replenine®-VF (High Purity Factor IX)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of Tamsulosin (Alpha Blockers) Compared to Phloroglucinol in Improving JJ Ureteral Stent Tolerance. A Randomized Controlled Trial
Status: COMPLETED
Conditions: Non-oncological Indication to Ureteral Stenting
Interventions: DRUG: Omexel|DRUG: spasfon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Efficacy of ACTIMMUNE® Dose Escalation in Friedreich's Ataxia Study
Status: COMPLETED
Conditions: Friedreich's Ataxia
Interventions: DRUG: Interferon γ-1b
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tissue Changes in Lumbar Multifidus After Dry Needling in Subjects With Nonspecific Low Back Pain.
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Dry needling|OTHER: Placebo dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Focused and Radial Extracorporeal Shock Wave for Carpal Tunnel Syndrome
Status: WITHDRAWN
Conditions: Carpal Tunnel Syndrome
Interventions: DEVICE: Extracorporeal shock wave
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Economic Evaluation of Nonbiological Artificial Liver Therapy in Acute-on-chronic Hepatitis B Liver Failure.
Status: COMPLETED
Conditions: Chronic-on-acute Liver Failure
Interventions: OTHER: KM-8800 plasma exchange device (Kuraray, Tokyo, Japan)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Disposable Balloon Uterine Stent in Patients With Asherman Syndrome
Status: UNKNOWN
Conditions: Intrauterine Adhesion
Interventions: DEVICE: disposable balloon uterine stent|DEVICE: Foley catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: High Dose Oral Steroids in Sudden Sensorineural Hearing Loss
Status: COMPLETED
Conditions: Sudden Sensorineural Hearing Loss (SSNHL)
Interventions: DRUG: Dexamethasone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PROceeding With Advanced Techniques in Case of Distal Malignant Biliary Obstruction and Difficult Biliary Cannulation comparEd With Therapeutic-EUS: the PROMETHEUS Trial
Status: NOT_YET_RECRUITING
Conditions: Malignant Biliary Obstruction
Interventions: PROCEDURE: pre-cut biliary sphincterotomy/fistulotomy, double guide wire (DGW) technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modafinil for Methamphetamine Dependence
Status: TERMINATED
Conditions: Methamphetamine Dependence
Interventions: DRUG: Modafinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physical Attendance Versus Telephone or Video Follow-up in Patients With Non-functioning Pituitary Tumors.
Status: NOT_YET_RECRUITING
Conditions: Non-Functional Pituitary Adenoma
Interventions: BEHAVIORAL: Telephone-/video follow-up|BEHAVIORAL: In-person follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: MK-5475 in Participants With Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease (PH-COPD) (MK-5475-006)
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: MK-5475|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Association Between Low Dose Acetylsalicylic Acid (ASA) and Proton Pump Inhibitors and Risk of Acute Myocardial Infarction or Coronary Heart Disease Death
Status: COMPLETED
Conditions: Nonfatal Myocardial Infarction|Coronary Death
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Interactive Multimedia Versus Illustrated Booklet on Behavior to Prevent Lower Back Pain in Working Nurses.
Status: COMPLETED
Conditions: Low Back Pain
Interventions: BEHAVIORAL: Interactive multimedia training and illustrated booklet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Shade Matching of Universal Versus Conventional Nanohybrid Resin Composites in Class IV Restorations After Bleaching
Status: RECRUITING
Conditions: Anterior Teeth
Interventions: OTHER: One shade universal composite|OTHER: Nanohybrid resin composite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Carboplatin Plus Irinotecan Versus Irinotecan in Children With Refractory Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: carboplatin + irinotecan|DRUG: irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of School-based Nutrition Intervention for Adolescents in Bangladesh
Status: COMPLETED
Conditions: Anemia|Menstrual Hygiene Management|Improved Water, Sanitation and Hygiene (WASH)
Interventions: DIETARY_SUPPLEMENT: Weekly Iron and Folic Acid Supplementation (WIFA)|COMBINATION_PRODUCT: WASH|COMBINATION_PRODUCT: Menstrual Hygiene Management|BEHAVIORAL: Nutrition Behavior Change Intervention (BCI)|BEHAVIORAL: MHM & WASH Behavior Change Intervention (BCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ciprofloxacin for the Prevention of Postoperative Endoscopic Recurrence in Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: Ciprofloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: TVT-Secur Versus TVT-Obturator: A Randomized Trial of Suburethral Sling Operative Procedures
Status: UNKNOWN
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: TVT-Obturator (TVT-O)|DEVICE: TVT-Secur (TVT-S) (Hammock method)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin and 5-Fluorouracil With or Without Docetaxel in Elderly Patients (>65 y) With Stomach and Esophagus Cancer
Status: COMPLETED
Conditions: Gastric Cancer|Adenocarcinoma of the Esophagogastric Junction
Interventions: DRUG: Docetaxel|DRUG: 5-Fluorouracil|DRUG: Oxaliplatin|DRUG: folinic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of High Protein Enteral Nutrition on Critically Ill Postoperative Children
Status: NOT_YET_RECRUITING
Conditions: Enteral Nutrition|Postoperative|Critically Ill Children
Interventions: DIETARY_SUPPLEMENT: Control Group|DIETARY_SUPPLEMENT: Intervention Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TLR Polymorphism, ASO and Beta-hemolytic Group A Streptococcus Infections in ADHD: an Observational Study
Status: UNKNOWN
Conditions: Attention Deficit-Hyperactivity Disorder
Interventions: DIAGNOSTIC_TEST: Antistreptolysin O Test|DIAGNOSTIC_TEST: Anti-Deoxyribonuclease B|DIAGNOSTIC_TEST: TLR, MyD88, IRAK-4 polymorphism|DIAGNOSTIC_TEST: Anti-Basal Ganglia Antibody
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Surgical Injury on Haemostatic Tests in Patients Undergoing Total Hip Replacement With Subgroup Analysis of Patients With Neoplasm
Status: RECRUITING
Conditions: Total Hip Replacement|Thromboelastometry|Bone Neoplasm of Hip
Interventions: DIAGNOSTIC_TEST: Rotational thromboelastometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Etanercept on the Heart, Veins and Thickness of Certain Major Arteries In Ankylosing Spondylitis Patients
Status: TERMINATED
Conditions: Ankylosing Spondylitis
Interventions: DRUG: etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SHengXIaN-QuYu DEcoction in the Treatment of Heart Failure With Reduced Ejection Fraction
Status: RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: ShengXian-QuYu Decoction|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Fluciclovine and PSMA PET/CT for the Classification and Improved Staging of Invasive Lobular Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Invasive Breast Lobular Carcinoma|Metastatic Breast Lobular Carcinoma|Prognostic Stage IV Breast Cancer AJCC v8
Interventions: PROCEDURE: Computed Tomography|DRUG: Fluciclovine F18|DRUG: Gallium Ga 68 Gozetotide|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neurodevelopmental and Growth Outcomes of Early, Aggressive Protein Intake in Very Low Birthweight Infants
Status: COMPLETED
Conditions: Prematurity
Interventions: DRUG: Amino acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MIPE for Pilonidal Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Pilonidal Disease|Pilonidal Cyst/Fistula|Pilonidal Sinus Without Abscess|Pilonidal Cyst Without Abscess|Pilonidal Cyst and Sinus Without Abscess|Pilonidal Abscess|Pilonidal Sinus With Abscess|Pilonidal Dimple With Abscess|Pilonidal Fistula With Abscess|Pilonidal Sinus Infected|Pilonidal Cyst With Sinus|Pilonidal Cyst and Sinus With Abscess|Pilonidal Disease of Natal Cleft Abscess
Interventions: PROCEDURE: minimally invasive pilonidal excision
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vitamin D Supplementation in the Prevention and Mitigation of COVID-19 Infection
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19|Vitamin D Deficiency|Respiratory Viral Infection
Interventions: DRUG: Daily Vitamin D3|DRUG: Daily placebo|DRUG: Bolus vitamin D3|DRUG: Bolus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Post Approval Study to Evaluate the Effectiveness and Safety of Cartiva Implant in the Treatment of OA of the Great Toe
Status: COMPLETED
Conditions: Osteoarthritis of First Metatarsalphalangeal Joint
Interventions: DEVICE: Cartiva
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy Trial of Mexiletine for Myotonic Dystrophy Type 1
Status: COMPLETED
Conditions: Myotonic Dystrophy
Interventions: DRUG: Mexiletine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Formulation-based CBT for Adult Inmates With ADHD: A Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: PROBECO|BEHAVIORAL: Formulation-based cognitive behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Project to Test the Efficacy and Safety of An Innovative Treatment for Opiate Use Disorders.
Status: RECRUITING
Conditions: Opioid Use Disorder, Moderate|Opioid Use|Opioid Dependence|Opioid Abuse|Opiate Dependence|Opioid Use, Unspecified
Interventions: DEVICE: unilateral transcranial photobiomodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Curcumin to Assess Recurrence Free Survival in Patients Who Have Had a Radical Prostatectomy
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Curcumin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Solvent Evaporation Time of Universal Adhesives in the Quality of Cervical Lesions Restorations
Status: COMPLETED
Conditions: Non-carious Cervical Lesions
Interventions: PROCEDURE: Evaporation time for 5 seconds|PROCEDURE: Evaporation time for 25 seconds|DEVICE: alcohol/water-based universal adhesive|DEVICE: acetone-based universal adhesive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of Novel Measures for Alzheimer's Disease Prevention Trials
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Participants
Interventions: OTHER: No Practice Effects (NPE) cognitive battery, and Miami Computerized Functional Assessment Scale (CFAS)|OTHER: Preclinical Alzheimer's Cognitive Composite (PACC), Alzheimer's Disease Assessment Scale-Cognitive Scale (ADAS-Cog), and Functional Assessment Questionnaire (FAQ)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease Study
Status: COMPLETED
Conditions: Mitral Regurgitation|Pulmonary Hypertension
Interventions: DIAGNOSTIC_TEST: Cardiac catheterisation|DIAGNOSTIC_TEST: Cardiopulmonary exercise testing|DIAGNOSTIC_TEST: Pulmonary function tests|DIAGNOSTIC_TEST: Cardiac MRI|OTHER: Quality of life survey|PROCEDURE: Mitral valve operation|PROCEDURE: Myocardial biopsies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Caudal Block With Bupivacaine and Dexmedetomidine Versus TAP Block With Bupivacaine Alone for Postoperative Analgesia in Pediatric Undergoing Infraumbical Surgeries
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: PROCEDURE: caudal block|DRUG: Dexmedetomidine|PROCEDURE: TAP|DRUG: Bupivacain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Two Strategies for Counseling Skin Examination and Sun Protection in First-degree Relatives of Patients With Melanoma
Status: COMPLETED
Conditions: Melanoma|Screening
Interventions: BEHAVIORAL: In-person counseling|BEHAVIORAL: Written advice|BEHAVIORAL: Medical skin screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Bortezomib, Cyclophosphamide, and Dexamethasone in Treating Patients With Primary Systemic Light Chain Amyloidosis
Status: COMPLETED
Conditions: Primary Systemic Amyloidosis
Interventions: DRUG: bortezomib|DRUG: cyclophosphamide|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Response of Dance 501 in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Inhaled Human Insulin|DRUG: Insulin Lispro (Humalog U-100)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Therapeutic Response and Survival of Patients With Metastatic Colorectal Cancer (Stage IV) and Treated According to the Guidelines of a Chemosensitivity Test, Oncogramme® (ONCOGRAM)
Status: COMPLETED
Conditions: Colorectal Cancer Metastatic|Chemotherapy
Interventions: OTHER: Oncogramme®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study of RGLS8429 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: RGLS8429|DRUG: Placebo volume-matching RGLS8429 dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Suprapectoral and Subpectoral Biceps Tenodesis
Status: WITHDRAWN
Conditions: Biceps Tendonitis
Interventions: PROCEDURE: Suprapectoral Biceps tenodesis|PROCEDURE: Subpectoral biceps tenodesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pattern Scanning Laser Pan-retinal Photocoagulation in Proliferative Diabetic Retinopathy
Status: COMPLETED
Conditions: Diabetic Retinopathy|Lasers|Treatment Outcome
Interventions: DEVICE: Pan-retinal photocoagulation using pattern scanning laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Differential Effects of Protein Quality on Postprandial Lipemia in Response to a Fat-Rich Meal in Type 2 Diabetes: Comparison of Whey, Casein, Gluten, and Cod Protein
Status: COMPLETED
Conditions: Type 2 Diabetes|Postprandial Lipemia
Interventions: DIETARY_SUPPLEMENT: Casein|DIETARY_SUPPLEMENT: Whey|DIETARY_SUPPLEMENT: Cod|DIETARY_SUPPLEMENT: Gluten
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Tezacitabine With or Without 5-Fluorouracil (5-FU) for Advanced Esophageal Cancer or Gastric Cancer
Status: COMPLETED
Conditions: Esophageal Neoplasms|Stomach Neoplasms|Adenocarcinoma
Interventions: DRUG: tezacitabine|DRUG: 5-fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of Focal Treatments of Localized Prostate Cancers With High Intensity Focused Ultrasound Using the Focal One® Device
Status: COMPLETED
Conditions: Localized Prostate Cancer
Interventions: DEVICE: Focal High Intensity Focused Ultrasound (HIFU) treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Label Study to Evaluate Safety, Tolerability and Clinical Utility of ULTRACET® (37.5mg Tramadol Hydrochloride/325mg Acetaminophen) for the Treatment of Breakthrough Pain in Cancer Patients
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: tramadol hydrochloride; acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Non-interventional Study in Overactive Bladder (OAB) Patients Prescribed Betmiga® as Part of Routine Clinical Practice
Status: COMPLETED
Conditions: Urgency Incontinence|Urinary Bladder Overactive|Overactive Bladder|Urologic Diseases|Urinary Bladder Diseases
Interventions: DRUG: Betmiga®
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Diagnosis of NPC Using the Probe-based Confocal Laser Endomicroscopy
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma|Squamous Cell Carcinoma of the Head and Neck
Interventions: DIAGNOSTIC_TEST: 10% fluorescein
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Oxaliplatin Plus Capecitabine in Treating Patients With Colorectal, Appendix, or Small Bowel Cancer
Status: COMPLETED
Conditions: Carcinoma of the Appendix|Colorectal Cancer|Small Intestine Cancer
Interventions: DRUG: capecitabine|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Bioequivalence of Molnupiravir, 200 mg Capsules and Lagevrio, 200 mg Capsules in Healthy Volunteers
Status: COMPLETED
Conditions: Viral Infection|COVID-19
Interventions: DRUG: Molnupiravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Pharmacokinetic and Tolerability Study of Fexinidazole in a Single Oral Dose in Adult Participants With Mild and Moderate Hepatic Impairment
Status: COMPLETED
Conditions: Hepatic Function Abnormal
Interventions: DRUG: Fexinidazole (HOE239)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluating Change in Drinking Identity as a Mechanism for Reducing Hazardous Drinking - Study 2
Status: COMPLETED
Conditions: Drinking; Excess, Habit (Continual)|Identity, Social
Interventions: BEHAVIORAL: Narrative Writing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study of Lanreotide in Non Metastatic Castration-resistant Prostate Cancer Patients
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Lanreotide, non steroidal anti androgens and LHRH-a|DRUG: Non steroidal anti androgens and LHRH-a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antiseptic Mouthwash / Pre-Procedural Rinse on SARS-CoV-2 Load (COVID-19)
Status: TERMINATED
Conditions: COVID-19|SARS-CoV 2|Severe Acute Respiratory Syndrome Coronavirus 2|Virus Disease|Coronavirus Infections|Pharyngeal Diseases
Interventions: DRUG: Oral-B Mouth Sore mouthwash|DRUG: Crest Pro-Health Multi-Protection mouthwash|DRUG: CloSYS Ultra Sensitive Rinse mouthwash|DRUG: Distilled water|DRUG: Listerine Zero Mouthwash Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy Of CACIPLIQ20 On Diabetic Ulcers In Patients Wearing An Nonremovable, Windowed, Fiberglass Cast Boot
Status: COMPLETED
Conditions: Foot Ulcer|Diabetes Mellitus|Diabetic Neuropathy
Interventions: DEVICE: CACIPLIQ20 and Nonremovable, Windowed, Fiberglass Cast Boot|DEVICE: Placebo and Nonremovable, Windowed, Fiberglass Cast Boot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Inhaled Nitric Oxide for Respiratory Failure in Newborns
Status: TERMINATED
Conditions: Infant, Newborn|Hypertension, Pulmonary|Persistent Fetal Circulation Syndrome|Pneumonia, Aspiration|Respiratory Distress Syndrome, Newborn|Respiratory Insufficiency
Interventions: DRUG: Inhaled Nitric Oxide|DRUG: Standard iNO therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioural Couple Intervention Therapy for Chinese Couples With a Depressed Partner
Status: NOT_YET_RECRUITING
Conditions: Depression
Interventions: BEHAVIORAL: Cognitive behavioural couple therapy (CBCT), Emotion focused couple therapy (EFCT), Wait-list control (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Dose Steroid Therapy to Treat Flares in Patients With Inflammatory Bowel Disease (IBD)
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases|Crohn Disease|Ulcerative Colitis|Indeterminate Colitis
Interventions: DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Caffeine in Preterm Neonates
Status: UNKNOWN
Conditions: BPD - Bronchopulmonary Dysplasia|Apnea of Prematurity|Hemodynamic Instability|Intubation
Interventions: DRUG: Caffeine Citrate|DRUG: Placebo (Normal Saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Traditional Chinese Medicine Herbs in the Freeze-all IVF Cycle
Status: UNKNOWN
Conditions: Infertility, Female
Interventions: DRUG: Prescription of traditional Chinese Medicine named Er Zhi Wan combined with Si Wu Tang|DRUG: Recombinant Human Follitropin Alfa for Injection、Fructose Injection、Tetyacycline Hydrochloride Capsules、Cetrorelix Acetate Powder for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: IGF-I/IGFBP-3 Therapy in Children and Adolescents With Growth Hormone Insenitivity Syndrome (GHIS) Such as Laron Syndrome
Status: COMPLETED
Conditions: Growth Hormone Insensitivity Syndrome (GHIS)|Laron Syndrome
Interventions: DRUG: rhIGF-I/rhIGFBP-3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of SHEN26 Capsule in Patients With Mild to Moderate COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: SHEN26 dose 1|DRUG: SHEN26 dose 2|DRUG: SHEN26 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Bolus and Continuous Nasogastric Feeding on Small Bowel Water Content and Blood Flow
Status: COMPLETED
Conditions: Enteral Feeding|Nasogastric Feeding|Diarrhoea
Interventions: DIETARY_SUPPLEMENT: NG bolus feeding over 5 min|DIETARY_SUPPLEMENT: Continuous NG feeding over 4 h
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Safety and Efficacy Study of Ustekinumab in Patients With Plaque Psoriasis Who Have Had an Inadequate Response to Methotrexate
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Ustekinumab|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Cytomegalovirus (CMV) Specific CD8+ T Cells as Treatment for CMV Reactivation
Status: WITHDRAWN
Conditions: CMV Reactivation|Allogeneic Stem Cell Transplantation|Autologous CMV Specific CD8+ T Cells
Interventions: PROCEDURE: Lymphopheresis|PROCEDURE: CMV specific lymphocyte infusion|PROCEDURE: Peripheral blood for CMV DNA PCR|PROCEDURE: Haematology/Blood chemistry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antiproliferative Effect of Octreotide in Patients With Metastasized Neuroendocrine Tumors of the Midgut
Status: COMPLETED
Conditions: Neuroendocrine Tumors
Interventions: DRUG: Octreotide LAR (Long-acting release)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combinational Rehabilitative Therapy and Functional Brain Imaging for Patients Recovering From Motor Stroke
Status: COMPLETED
Conditions: Ischaemic Stroke
Interventions: DRUG: Levodopa|OTHER: Virtual Reality based therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Capecitabine, Oxaliplatin and Trastuzumab in Treating Patients With HER2 Positive Metastatic Breast Cancer
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Capecitabine|DRUG: Oxaliplatin|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Immunogenicity of Gam-COVID-Vac Vaccine in a Nasal Spray
Status: UNKNOWN
Conditions: COVID-19|SARS-CoV-2 Acute Respiratory Disease
Interventions: BIOLOGICAL: Gam-COVID-Vac|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability Study for T-1101 (Tosylate) Capsules to Treat Advanced Refractory Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Refractory Solid Tumors
Interventions: DRUG: T-1101 (Tosylate)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of TAK-085 in Participants With Hypertriglyceridemia
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DRUG: Omega-3-acid ethyl esters 90 (TAK-085)|DRUG: Eicosapentaenoic acid-ethyl (EPA-E)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-arterial Cisplatin Plus Rh-endostatin Combined With Systematic Chemotherapy in Osteosarcoma
Status: NOT_YET_RECRUITING
Conditions: Osteosarcoma|Bone Cancer
Interventions: DRUG: intra-arterial cisplatin plus anti-angiogenesis inhibitor rh-endostatin (Endostar)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Immunogenicity and Safety of a Recombinant Protein COVID-19 Vaccine as a Booster Dose in Population Aged 12-17 Years
Status: UNKNOWN
Conditions: COVID-19|SARS-CoV-2 Infection
Interventions: BIOLOGICAL: SCTV01E|BIOLOGICAL: mRNA-1273
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Performance of Existing Wearers of Enfilcon A Following a Refit With Fanfilcon A Lenses for 4 Weeks
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: fanfilcon A (test)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Hypoglycaemia Awareness Restoration Programme
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Hypoglycemia
Interventions: BEHAVIORAL: HARPdoc courses|BEHAVIORAL: BGAT courses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Ovarian Epithelial or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: BIOLOGICAL: incomplete Freund's adjuvant|BIOLOGICAL: ovarian cancer peptide vaccine|BIOLOGICAL: sargramostim|BIOLOGICAL: tetanus toxoid helper peptide|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Varenicline (Champix) in Smoking Cessation for Patients Post-Acute Coronary Syndrome (EVITA) Trial
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: varenicline|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dual Focus NBI and pCLE in FAP Related Duodenal Adenoma
Status: COMPLETED
Conditions: Complication of Diagnostic Procedure|Adverse Effect of Diagnostic Agents, Subsequent Encounter
Interventions: PROCEDURE: Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bumblebee Breath Effect on Tinnitus in Older Patients
Status: UNKNOWN
Conditions: Tinnitus, Subjective
Interventions: BEHAVIORAL: Bumblebee Breath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: OUTcomes Evaluation of Current Therapeutic STrategies for Severe Aortic Valve steNosis anD the agING Population in ITALY
Status: RECRUITING
Conditions: Aortic Valve Stenosis
Interventions: PROCEDURE: TAVR (Transcatheter Aortic Valve Replacement)|PROCEDURE: AVR (Aortic Valve Replacement)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Lower Extremity ROM Exercises on Hypotension, Fatigue, and Hemodialysis Comfort in Individuals
Status: COMPLETED
Conditions: Hemodialysis
Interventions: BEHAVIORAL: ROM exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dose-finding Study Using Pentostatin for Injection in the Treatment of Steroid-refractory aGvHD
Status: TERMINATED
Conditions: Acute Graft Versus Host Disease
Interventions: DRUG: pentostatin for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Inspiratory Muscle Training on Dyspnea Perception During Exercise in Patients With COPD
Status: COMPLETED
Conditions: COPD|Severe Systemic Illness-induced Respiratory Muscle Wasting
Interventions: DEVICE: Inspiratory Muscle Strength Training|DEVICE: Inspiratory Muscle Endurance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subacromial Impingement - The Need of Arthroscopic Subacromial Decompression After Eccentric Physical Therapy Exercises
Status: COMPLETED
Conditions: Subacromial Impingement Syndrome
Interventions: PROCEDURE: Exercise program|PROCEDURE: Movement exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 'COMBINE-2': Real-world Evidence for Effectiveness of Two Drug Regimen, Antiretroviral Therapy With Integrase Inhibitors Plus a Reverse Transcriptase Inhibitor
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Dolutegravir (DTG)|DRUG: Lamivudine (3TC)|DRUG: Rilpivirine (RPV)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Genetic Variation in TMPRSS6 Gene (SNP rs855791) on Oral Iron Absorption: an Iron Stable Isotope Study
Status: COMPLETED
Conditions: Iron Metabolism Disorders
Interventions: DIETARY_SUPPLEMENT: Testmeal A|DIETARY_SUPPLEMENT: Testmeal B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Testing the Addition of Ipatasertib to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) for Stage III or IV Epithelial Ovarian Cancer
Status: RECRUITING
Conditions: Fallopian Tube Endometrioid Adenocarcinoma|Fallopian Tube High Grade Serous Adenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian High Grade Serous Adenocarcinoma|Primary Peritoneal Endometrioid Adenocarcinoma|Primary Peritoneal High Grade Serous Adenocarcinoma|Stage III Fallopian Tube Cancer AJCC v8|Stage III Ovarian Cancer AJCC v8|Stage III Primary Peritoneal Cancer AJCC v8|Stage IV Fallopian Tube Cancer AJCC v8|Stage IV Ovarian Cancer AJCC v8|Stage IV Primary Peritoneal Cancer AJCC v8|Unresectable Fallopian Tube Endometrioid Adenocarcinoma|Unresectable Fallopian Tube High Grade Serous Adenocarcinoma|Unresectable Ovarian Endometrioid Adenocarcinoma|Unresectable Ovarian High Grade Serous Adenocarcinoma|Unresectable Primary Peritoneal Endometrioid Adenocarcinoma|Unresectable Primary Peritoneal High Grade Serous Adenocarcinoma
Interventions: PROCEDURE: Biopsy|DRUG: Carboplatin|DRUG: Ipatasertib|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRI of the Chest Under High Frequency Ventilation
Status: COMPLETED
Conditions: Non-invasive Ventilation|High-frequency Ventilation|Healthy Volunteer
Interventions: DEVICE: MRI with High-frequency non-invasive ventilation|OTHER: MRI without High-frequency non-invasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mesenchymal Stem Cells Co-transplantation in Alternative Donor Transplantation of Severe Aplastic Anemia.
Status: UNKNOWN
Conditions: Severe Aplastic Anemia
Interventions: BIOLOGICAL: mesenchymal stem cells|BIOLOGICAL: mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Effectiveness of Galantamine Versus Placebo in the Treatment of Patients With Vascular Dementia or Mixed Dementia
Status: COMPLETED
Conditions: Alzheimer Disease|Vascular Dementia
Interventions: DRUG: galantamine hydrobromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Retraction Cords on the Gingival Margin Level.
Status: RECRUITING
Conditions: Gingival Retraction|Gingival Recession|Periodontal Health
Interventions: PROCEDURE: Non-impregnated retraction cords/ less than 10 minutes|PROCEDURE: Non-impregnated retraction cords/ more than 10 minutes|DRUG: impregnated gingival retraction cord - less than 10 minutes|DRUG: impregnated gingival retraction cord - more than 10 minutes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Agonist-Antagonist Myoneural Interface for Functional Limb Restoration After Transtibial Amputation
Status: RECRUITING
Conditions: Amputation
Interventions: PROCEDURE: AMI transtibial amputation|PROCEDURE: Standard transtibial amputation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Inflammatory Markers in ph Negative Myeloproliferative Neoplasms: Impact on Outcome and Response to Therapy. Multicenter Retro-prospective Observational Study. The INFLA-ME (INFLAmmation in Myeloproliferative Disease) Study.
Status: RECRUITING
Conditions: Myeloproliferative Disease|Inflammatory Markers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Neuromuscular Electrical Stimulation in Patients With Subacromial Impingement Syndrome
Status: COMPLETED
Conditions: Subacromial Impingement Syndrome
Interventions: PROCEDURE: Neuromuscular Electrical Stimulation (NMES)|PROCEDURE: Exercise Training (ET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b Trial to Evaluate the Safety and Immunogenicity of a SARS-CoV-2 mRNA Chimera Vaccine Against COVID-19
Status: UNKNOWN
Conditions: COVID-19
Interventions: BIOLOGICAL: RQ3013|BIOLOGICAL: Comirnaty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: GnRH Agonist at Embryo Transfer: IVF Outcomes
Status: WITHDRAWN
Conditions: Infertility|Infertility, Female|Infertility, Male
Interventions: DRUG: Saline Solution for Injection|DRUG: Leuprolide Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Measurement of the Prevalence of Sensory Integration Disorders in Babies Having Heart Disease Surgery for Transposition of the Great Vessels Before 6 Months of Age
Status: UNKNOWN
Conditions: Great Vessels Transposition Surgery
Interventions: OTHER: Dunn-2 infant Sensory Profile (PS2-N)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ribavirin to Prevent RSV Pneumonia in Bone Marrow Transplant Patients
Status: TERMINATED
Conditions: Respiratory Syncytial Virus Infections
Interventions: DRUG: Virazole (Ribavirin) Inhalation Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION