pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Vesalio NeVa Stent Retriever Study for Treatment of Large Vessel Occlusion Strokes
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DEVICE: NeVa Stent Retrievers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Crisaborole Ointment 2%; Crisaborole Vehicle; TCS and TCI in Subjects Aged ≥ 2 Years, With Mild-moderate AD
Status: TERMINATED
Conditions: Atopic Dermatitis
Interventions: DRUG: Crisaborole ointment, 2%|DRUG: Hydrocortisone butyrate cream, 0.1%|DRUG: Pimecrolimus cream, 1%|DRUG: Crisaborole Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effective Use of Pecs and Transversus Thoracics Plane Blocks for Subcutaneous Cardiac Pacemaker Insertion: A Case Series
Status: WITHDRAWN
Conditions: Anesthesia, Local
Interventions: PROCEDURE: PEC I and PEC II blocks
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Ketamine and Postoperative Pain Following Cesarean Section.
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Ketamine|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Remifentanil Effect on Burst Suppression Ratio
Status: NOT_YET_RECRUITING
Conditions: Anesthesia, Intravenous|Electroencephalography|Burst Suppression
Interventions: DRUG: High dose of remifentanil|DRUG: Medium dose of remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Neural Mechanisms of Anesthesia and Human Consciousness (Part 6)
Status: COMPLETED
Conditions: Anesthesia|Unconsciousness
Interventions: DRUG: Dexmedetomidine|DRUG: Propofol|DRUG: S-ketamine|DRUG: Sevoflurane|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Non Invasive Ventilation for Acute Exacerbations in Adult CF
Status: UNKNOWN
Conditions: Cystic Fibrosis|Respiratory Failure
Interventions: DEVICE: Bi level pressure support|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Age-associated Arterial Dysfunction, Western Diet, and Aerobic Exercise: Role of the Gut Microbiome
Status: UNKNOWN
Conditions: Aging
Interventions: OTHER: Western Diet|OTHER: Non-Western Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hemorrhoid Artery LigatioN Without Doppler Trial
Status: UNKNOWN
Conditions: Hemorrhoids
Interventions: PROCEDURE: doppler-guided hemorrhoidal artery ligation|PROCEDURE: Finger-guided hemorrhoidal artery ligation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Microbiome as a Biomarkers in Locoregionally-Advanced Oropharyngeal Squamous Cell Carcinoma 2
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: MET-4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability of Ledipasvir/Sofosbuvir (LDV/SOF) Treatment for HIV/HCV Co-infected Participants Who Switch to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (E/C/F/TAF) or Emtricitabine/Rilpivirine/Tenofovir Alafenamide (F/R/TAF) Prior to LDV/SOF HCV Treatment
Status: COMPLETED
Conditions: HIV-1 Infection|HCV Infection
Interventions: DRUG: E/C/F/TAF|DRUG: F/R/TAF|DRUG: LDV/SOF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stress Inoculation Through Virtual Reality in the Pediatric Electrophysiology Laboratory
Status: COMPLETED
Conditions: Stress, Psychological|Stress, Physiological|Anxiety|Pain Perception
Interventions: BEHAVIORAL: Use of Virtual Reality App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Intraoperative Continuous Airway Pressure (CPAP) on the Inflammatory Response to One-lung Ventilation
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: PROCEDURE: CPAP (Continuous airway pressure)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Change in Disease Activity and Adverse Events of Adalimumab in Chinese Participants Requiring High Dose Corticosteroids for Active Non-Infectious Intermediate, Posterior, or Pan-Uveitis
Status: COMPLETED
Conditions: Non-infectious Intermediate Posterior- or Pan-uveitis
Interventions: DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mushroom Ingestion Study
Status: COMPLETED
Conditions: Diet, Healthy
Interventions: OTHER: Yellow Oyster -- 84 g|OTHER: Yellow Oyster -- 168 g|OTHER: White button -- 84 g|OTHER: White button -- 168 g|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effect of Dexmedetomidine on Sevoflurane Requirements and Emergence Agitation in Children Undergoing Ambulatory Surgery
Status: COMPLETED
Conditions: Ambulation Difficulty
Interventions: DRUG: Dexmedetomidine|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rosuvastatin in Treating Women With Cardiovascular Complications Who Are Undergoing Chemotherapy For Breast Cancer
Status: TERMINATED
Conditions: Cardiovascular Complications|Recurrent Breast Cancer|Stage I Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: rosuvastatin|OTHER: placebo|OTHER: survey administration|PROCEDURE: management of therapy complications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Electrical Stimulation (TES) at Slow Oscillation (SO) Frequency During NREM Sleep
Status: UNKNOWN
Conditions: Sleep Deprivation|Mental Competency
Interventions: DEVICE: NeuroConn DC Stimulator PLUS|DEVICE: SHAM TES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Properties of GLPG1690 in Subjects With Idiopathic Pulmonary Fibrosis (IPF)
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: GLPG1690 600 mg QD|DRUG: Placebo QD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Changes in Vaginal Microbiota Profiles Before and After Vaginal Urogynecologic Surgery
Status: COMPLETED
Conditions: Gynecological Surgery
Interventions: OTHER: Vaginal swabs|OTHER: Stool samples|OTHER: Urine samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Low Doses of V24343 in Obese Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: V24343
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: GM-CSF for Reversal of Immunoparalysis in Pediatric Sepsis-induced MODS
Status: RECRUITING
Conditions: Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome
Interventions: DRUG: GM-CSF|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stability and Outcomes of Non-displaced Lisfranc Injuries
Status: ACTIVE_NOT_RECRUITING
Conditions: Lisfranc Injury|Sprain of Foot
Interventions: PROCEDURE: Minimally invasive stabilization of Lisfranc injuries|PROCEDURE: Conservative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Caregiver Support in the Quality of Life of Patients Who Are Undergoing Donor Bone Marrow Transplantation
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases|Psychosocial Effects of Cancer and Its Treatment
Interventions: PROCEDURE: psychosocial assessment and care|PROCEDURE: Quality of Life Assessments
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Screening of Sleep Apnea by Holter Electrocardiography: Validation of Heart Rate Variability Analysis Algorithm
Status: COMPLETED
Conditions: Sleep Apnea Syndromes
Interventions: DEVICE: Holter ECG Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Gemcitabine-Carboplatin Plus Necitumumab (LY3012211) in Chemotherapy-Naïve Participants With Locally Advanced or Metastatic Squamous Non-Small Cell Lung Cancer (NSCLC)
Status: WITHDRAWN
Conditions: Locally Advanced Squamous Non-Small Cell Lung Cancer|Metastatic Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: Necitumumab|DRUG: Gemcitabine|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ventricular Arrhythmia Ablation With the Use of Non-Invasive ECG Imaging Technology
Status: WITHDRAWN
Conditions: Premature Ventricular Contraction|Ventricular Tachycardia
Interventions: OTHER: VIVO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Minimally Non Surgical Periodontal Therapy Compared to Traditional Approach
Status: NOT_YET_RECRUITING
Conditions: Periodontal Diseases|Periodontal Inflammation
Interventions: PROCEDURE: Gracey micro-curettes|PROCEDURE: Standard Gracey curettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Basic and Applied Research on Extinction Bursts
Status: RECRUITING
Conditions: Problem Behavior|Aggression|Self Injury
Interventions: BEHAVIORAL: Extinction-only condition|BEHAVIORAL: Rate-drop condition|BEHAVIORAL: Rate-hold condition|BEHAVIORAL: Magnitude-drop condition|BEHAVIORAL: Magnitude-hold condition|BEHAVIORAL: Quality-drop condition|BEHAVIORAL: Quality-hold condition|BEHAVIORAL: Rate-drop/quality-increase condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Delivery Room Management Trial of Premature Infants at High Risk of Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Newborn
Interventions: DRUG: PS Group|DEVICE: NCPAP Group|DRUG: ISX Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Colectomy Reconstruction for Ulcerative Colitis, Ileorectal Anastomosis vs Ileal Pouch-Anal Anastomosis in Ulcerative Colitis.
Status: RECRUITING
Conditions: Ulcerative Colitis|Inflammatory Bowel Diseases|Ileostomy - Stoma
Interventions: PROCEDURE: Ileorectal anastomosis (IRA)|PROCEDURE: Ileal pouch anal anastomosis (IPAA)|PROCEDURE: ileostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Self Monitored Blood Glucose (SMBG) to Continuous Glucose Monitoring (CGM) in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DEVICE: CGM Group|DEVICE: SMBG Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resveratrol in Patients With Non-alcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Fatty Liver
Interventions: DIETARY_SUPPLEMENT: Resveratrol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hysteroscopic Surgery in Treatment of Intrauterine Abnormalities
Status: WITHDRAWN
Conditions: Hysteroscopy
Interventions: PROCEDURE: Hysteroscopy|PROCEDURE: Office hysteroscopy|PROCEDURE: Conventional hysteroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Fasting and Hydro Colon Therapy Plus Probiotics on GI Microbiota in Intolerances and Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Disease
Interventions: OTHER: Hydro Colon Therapy plus probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of a Renin Inhibitor, Aliskiren, Compared to Enalapril, in C3 Glomerulopathy
Status: RECRUITING
Conditions: C3 Glomerulopathy|Membranoproliferative Glomerulonephritis|Complement Abnormality|Dense Deposit Disease|C3 Glomerulonephritis
Interventions: DRUG: Aliskiren|DRUG: Enalapril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, Tolerability, and Pharmacokinetics of NBI-827104 in Pediatric Subjects With Epileptic Encephalopathy With Continuous Spike-and-Wave During Sleep
Status: COMPLETED
Conditions: Epileptic Encephalopathy|Continuous Spike and Wave During Sleep
Interventions: DRUG: NBI-827104|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First International Randomized Study in Malignant Progressive Pheochromocytoma and Paraganglioma
Status: COMPLETED
Conditions: Malignant Progressive Pheochromocytoma and Paraganglioma (PPGL)
Interventions: DRUG: Sunitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of XJ-Procedure in Patients With Acute Type A Aortic Dissection Surgery
Status: RECRUITING
Conditions: Type A Aortic Dissection|Complication of Surgical Procedure|Aortic Diseases
Interventions: PROCEDURE: Vascular Grafts Eversion and Built-in Technique(XJ-Procedure)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Supragingival Irrigators Containing Chlorhexidine on Oral Health in Blood Dyscrasia
Status: COMPLETED
Conditions: Severe Neutropenia|Thrombocytopenia|Chemotherapy|Blood Dyscrasia Patients
Interventions: DEVICE: supragingival irrigators containing chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Medifast 5 & 1 Plan
Status: COMPLETED
Conditions: Obesity|Body Weight|Weight Loss|Overweight|Nutrition Disorders
Interventions: BEHAVIORAL: Food-based, Reduced Energy Diet Plan|OTHER: Medifast 5 & 1 Plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Capsule Sparing Cystectomy and Radical Cystoprostatectomy in Men With Bladder Cancer
Status: RECRUITING
Conditions: Bladder Cancer
Interventions: PROCEDURE: Capsule Sparing Cystectomy (CSC)|PROCEDURE: Conventional Radical Cystoprostatectomy (CRC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Efficacy, Safety and PK of Adefovir Dipivoxil Liquid Suspension in Patients With Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Adefovir Dipivoxil for oral suspension, 2 mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-42721458 in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-42721458 (single dose)|DRUG: JNJ-42721458 (multiple doses)|DRUG: Placebo (single dose)|DRUG: Placebo (multiple doses)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Companion Protocol for ¹³C-Methacetin Breath Tests in BMS: NCT03486899, NCT03486912 Referenced Trials
Status: COMPLETED
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: COMBINATION_PRODUCT: ¹³C-Methacetin Breath Test|DRUG: BMS-986036|DEVICE: BreathID MCS device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Turoctocog Alfa in Previously Treated Male Children With Haemophilia A
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A
Interventions: DRUG: turoctocog alfa|DRUG: turoctocog alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Adipose Derived Stem Cells for Non-Ischemic Congestive Heart Failure
Status: WITHDRAWN
Conditions: Non-Ischemic Congestive Heart Failure
Interventions: PROCEDURE: Harvesting and Implantation of Adipose-Derived Stem Cells (ASCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Water and Sudafed in Autonomic Failure
Status: TERMINATED
Conditions: Shy-Drager Syndrome|Multiple System Atrophy
Interventions: DRUG: Pseudoephedrine + 480 ml water|DRUG: Pseudoephedrine + 50 ml water|OTHER: Placebo + 480 ml water (optional)|OTHER: Placebo + 50 ml water (optional)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Culturally Adapted Brief Intervention for Heavy Drinking Hispanic Men
Status: TERMINATED
Conditions: Alcohol Consumption
Interventions: BEHAVIORAL: Non-adapted brief motivational interview|BEHAVIORAL: Culturally adapted brief motivational interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Systematic Light Exposure for Fatigue in Breast Cancer Patients
Status: COMPLETED
Conditions: Cancer-related Problem/Condition|Fatigue|Circadian Rhythm Disorders
Interventions: DEVICE: Light Glasses (Experimental)|DEVICE: Light Glasses (Comparison)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lenalidomide in Treating Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplant
Status: ACTIVE_NOT_RECRUITING
Conditions: DS Stage I Multiple Myeloma|DS Stage II Multiple Myeloma|DS Stage III Multiple Myeloma|Refractory Multiple Myeloma|Smoldering Multiple Myeloma
Interventions: PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation|OTHER: Laboratory Biomarker Analysis|DRUG: Lenalidomide|DRUG: Melphalan|PROCEDURE: Peripheral Blood Stem Cell Transplantation|OTHER: Placebo Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Network Activation in Patients With Movement Disorders
Status: UNKNOWN
Conditions: Parkinson Disease|Essential Tremor|Dystonia|Normal Pressure Hydrocephalus|Cerebellar Ataxia|Multiple System Atrophy|Progressive Supranuclear Palsy|Corticobasal Degeneration|Dementia With Lewy Bodies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Botulinum Toxin for Pelvic Pain in Women With Endometriosis
Status: COMPLETED
Conditions: Endometriosis|Chronic Pelvic Pain|Pelvic Muscle Spasm|Quality of Life
Interventions: DRUG: Botulinum toxin (BoNT)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Insulin Sensitivity of the Human CNS System: fMRI Study With Intranasal Insulin Application
Status: COMPLETED
Conditions: Obesity|Diabetes
Interventions: DRUG: Human Insulin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Performance Thresholds Evaluation by Wet Injection Quantification and Magnetic Resonance Imaging (MRI) of Subcutaneous and Intramuscular Injections (0,65ml) of Several Configurations of Needle-free Devices (ZENEO®)
Status: COMPLETED
Conditions: No Condition
Interventions: COMBINATION_PRODUCT: Intramuscular ZENEO® injection|COMBINATION_PRODUCT: Subcutaneous high ZENEO® injection|COMBINATION_PRODUCT: Subcutaneous low ZENEO® injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase 2 Study on Use of a Combination of Pemetrexed in Patients With Advanced Gastric Carcinoma
Status: COMPLETED
Conditions: Gastrointestinal Neoplasms
Interventions: DRUG: pemetrexed|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Attentional Bias Modification in Patients With Posttraumatic Stress Disorder
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Attentional Bias Modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeting NUDT21 siRNA Drugs for Patients With Refractory Retinoblastoma
Status: NOT_YET_RECRUITING
Conditions: Retinoblastoma|Refractory
Interventions: DRUG: Targeting NUDT21 siRNA drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritional Therapy Study in Pediatric Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: OTHER: Traditional SCD Diet|OTHER: Modified SCD Diet|OTHER: Whole foods diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Osimertinib With or Without Bevacizumab in Treating Patients With EGFR Positive Non-small Cell Lung Cancer and Brain Metastases
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Lung Non-Small Cell Carcinoma|Metastatic Malignant Neoplasm in the Brain|Stage IV Lung Cancer AJCC v8
Interventions: BIOLOGICAL: Bevacizumab|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide and Filgrastim in Treating Patients With Stage IV, Relapsed, or Refractory Low-Grade Follicular Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|DRUG: cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NWRD08 DNA Plasmid for HPV-16 and/or HPV-18 Related Cervical HSIL
Status: RECRUITING
Conditions: High-grade Squamous Intraepithelial Lesion (HSIL)
Interventions: BIOLOGICAL: NWRD08 administered by electroporation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Safety and Efficacy of Autologous Gene-edited Muscle Stem Cells (GenPHSats-bASKet)
Status: NOT_YET_RECRUITING
Conditions: LGMD
Interventions: BIOLOGICAL: GenPHSat injection (Safety)|BIOLOGICAL: GenPHSat injection (Efficacy)|OTHER: Muscle Biopsy (Safety)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Progressive Muscle Relaxation Exercise on Primary Dysmenorrhea Menstrual Symptoms and Quality of Life.
Status: UNKNOWN
Conditions: Primary Dysmenorrhea|Quality of Life
Interventions: BEHAVIORAL: ROGRESSIVE MUSCLE RELAXATION EXERCISE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Solifenacin on Post Void Dribbling in Women
Status: COMPLETED
Conditions: Post-micturition Incontinence|Incontinence
Interventions: DRUG: solifenacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anemia Studies in CKD: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat- Iron (ASCEND: Fe)
Status: COMPLETED
Conditions: Anaemia
Interventions: DRUG: Daprodustat|DRUG: rhEPO|DRUG: Ferrous sulfate containing the stable iron isotope (57Fe)|DRUG: Ferrous sulfate containing the stable iron isotope (58Fe)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between Socket Shield Technique Versus Allograft Buccal Sheet Technique on Alveolar Bone Resorption After Immediate Implant Placement
Status: COMPLETED
Conditions: Bone Loss in Jaw
Interventions: PROCEDURE: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Peri-sphincter Injection of Autologous Myofibres to Treat of Urinary Incontinence by Sphincter Deficiency
Status: COMPLETED
Conditions: Urinary Incontinence by Intrinsic Sphincter Deficiency
Interventions: OTHER: Peri sphincter injection Autologous myofibers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RePOSA-Revealing the Efficacy of IHL-42X Use in Patients With OSA
Status: RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: IHL-42X Low Dose|DRUG: IHL-42X High Dose|DRUG: Placebo|DRUG: IHL-42X (Optimal Dose)|DRUG: Dronabinol|DRUG: Acetazolamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MK1006 (MK-1006-002)(COMPLETED)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: MK1006|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of LibiGel® for Treatment of Hypoactive Sexual Desire Disorder in Surgically Menopausal Women
Status: COMPLETED
Conditions: Hypoactive Sexual Desire Disorder
Interventions: DRUG: testosterone gel|DRUG: placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Plus Carboplatin or Cisplatin in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: cisplatin|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Ketogenic Diet and Chemotherapy in Affecting Recurrence in Patients With Stage IV Breast Cancer
Status: COMPLETED
Conditions: Stage IV Breast Cancer AJCC v6 and v7
Interventions: DIETARY_SUPPLEMENT: Dietary Intervention|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Using Available Data to Learn to What Extent Patients With Prostate Cancer Who Received Second Generation Androgen Receptor Inhibitors Took Their Medication as Prescribed or Stopped Taking Their Medication Completely
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Darolutamide (Nubeqa, BAY1841788)|DRUG: Enzalutamide|DRUG: Apalutamide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Microfracture in Rotator Cuff Injury Repair
Status: SUSPENDED
Conditions: Rupture of the Rotator Cuff
Interventions: PROCEDURE: Microfracture|PROCEDURE: NO microfracture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Erector Spinae Plane Block on Post-operative Pain and Diaphragmatic Dysfunction in Epigastric Hernia
Status: COMPLETED
Conditions: Epigastric Hernia Repair|Erector Spinae Plane Block|Post Operative Pain|Diaphragmatic Dysfunction
Interventions: PROCEDURE: The erector spinae plane block group|PROCEDURE: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Weight Regain Treatment Post-Bariatric Surgery
Status: COMPLETED
Conditions: Obesity, Overweight
Interventions: BEHAVIORAL: Behavioral Weight Loss (BWL)|BEHAVIORAL: Early Responder: BWL continued|COMBINATION_PRODUCT: Early Non-responder: BWL continued with medication added
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Safety and Immunogenicity of Recombinant HIV-1 Envelope Protein BG505 SOSIP.GT1.1 gp140 Vaccine, Adjuvanted in Healthy, HIV-uninfected Adults
Status: UNKNOWN
Conditions: HIV Infections
Interventions: BIOLOGICAL: BG505 SOSIP GT1.1 gp140 Vaccine, Adjuvanted|BIOLOGICAL: BG505 SOSIP GT1.1 gp140 Vaccine, Adjuvanted|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Electrocardiographic Measurements by High Density Electrode ECG (ECG-HD)
Status: RECRUITING
Conditions: Ventricular Arrhythmias
Interventions: DEVICE: HD ECG|DEVICE: Conventional 12-lead ECG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Safety and Tolerability Study of Sotrovimab (VIR-7831) Prophylaxis Against COVID-19 in Immunocompromised Individuals
Status: COMPLETED
Conditions: SARS CoV 2 Infection
Interventions: DRUG: Sotrovimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nifurtimox Versus Benznidazole Effectiveness and Tolerance for Chagas Disease Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Chagas Disease
Interventions: OTHER: Clinical Manifestations|DIAGNOSTIC_TEST: Serologic response|DIAGNOSTIC_TEST: Direct method|BEHAVIORAL: Adverse events
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Thermal Evaluation in Prevention of Diabetic Foot Ulcer
Status: COMPLETED
Conditions: Diabetic Foot
Interventions: OTHER: Thermal Evaluation and Foot Care|OTHER: Foot Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Probiotic and Gastrointestinal Symptoms Due to Menstruation in Healthy Women
Status: COMPLETED
Conditions: Menstrual Discomfort
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of Intranasal Versus Intravenous Fentanyl in Preterm and Term Newborns for Pain Prevention
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Apathy in Dementia Methylphenidate Trial 2
Status: COMPLETED
Conditions: Apathy|Alzheimer's Disease
Interventions: DRUG: Methylphenidate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bromocriptine in the Treatment of Peripartum Cardiomyopathy
Status: WITHDRAWN
Conditions: Peripartum Cardiomyopathy
Interventions: DRUG: Bromocriptine|OTHER: Guideline-driven medical therapy (GDMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epidural vs. Wound Catheter Following Liver Resection
Status: COMPLETED
Conditions: Transplant Surgery
Interventions: PROCEDURE: This arm will received perioperative transversus abdominis plane (TAP) block followed by continuous infusion of local anaestheic by wound catheters and an IV morphine PCA.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: OTHER
Clinical trial: Plantaris Release for Non-insertional Achilles Tendinopathy
Status: UNKNOWN
Conditions: Tendinopathy|Achilles Tendon
Interventions: PROCEDURE: Plantaris release under ultrasound guidance|PROCEDURE: Plantaris excision surgically
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Cholangiography and Intraoperative Cholangiography in Acute Cholecystitis
Status: COMPLETED
Conditions: Acute Cholecystitis
Interventions: DIAGNOSTIC_TEST: Magnetic resonance cholangiography|DIAGNOSTIC_TEST: Intraoperative cholangiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Genomic-guided 'Standard-of-care' Chemotherapy for in Advanced Gastric Cancer Patients
Status: UNKNOWN
Conditions: Recurrent Gastric Cancer
Interventions: DRUG: TS-1 with cisplatin|DRUG: TS-1 with oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Breast Magnetic Resonance Imaging (MRI) and Contrast-enhanced Mammography (CEM)
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer Female
Interventions: OTHER: State-Trait Anxiety Inventory (STAI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: European Sapheon™ Closure System Observational ProspectivE (eSCOPE) Study
Status: COMPLETED
Conditions: Venous Insufficiency of Leg
Interventions: DEVICE: CE Marked Sapheon Closure System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Randomized Study: Assessment of PRF Efficacy in Prevention of Jaw Osteonecrosis After Tooth Extraction
Status: UNKNOWN
Conditions: Bisphosphonate-Associated Osteonecrosis of the Jaw
Interventions: DRUG: tooth extraction with antibiotics (amoxicillin- clavulanate, clindamycine)|PROCEDURE: atraumatic extraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A First-in-Human Study to Learn About How BAY3630942 is Distributed and Processed Inside the Body When Given After BAY3547922 and How Safe it is in People With Liver Cancer or Other Select Solid Cancers
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma (HCC)|Solid Tumors
Interventions: DRUG: BAY3630942|DRUG: BAY3547922
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Alleviating Pre-operative Anxiety With Innovative 3D Immersive Virtual Reality
Status: COMPLETED
Conditions: Virtual Reality|Anxiety|Preoperative Anxiety
Interventions: OTHER: IPAD|OTHER: VR Goggles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy in Treating Patients With Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer|Urethral Cancer
Interventions: DRUG: carboplatin|DRUG: cisplatin|DRUG: doxorubicin hydrochloride|DRUG: methotrexate|DRUG: paclitaxel|DRUG: vinblastine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: First Line Treatment With Olaparib in Combination With Bevacizumab in HRD Positive Patients
Status: RECRUITING
Conditions: Carcinoma, Ovarian Epithelial
Interventions: DRUG: Olaparib|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Long-Term Safety of BLI5100 in Patients With Gastroesophageal Reflux Disease
Status: ENROLLING_BY_INVITATION
Conditions: Non-erosive Reflux Disease|Erosive Esophagitis
Interventions: DRUG: BLI5100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Dose-Range of Navarixin (SCH 527123, MK-7123) in Participants With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) (MK-7123-012)
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Navarixin 1 mg|DRUG: Navarixin 10 mg|DRUG: Placebo to match navarixin|DRUG: Rescue medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Explore the Efficacy of TRV027 in Patients Hospitalized for Acute Decompensated Heart Failure
Status: COMPLETED
Conditions: Acute Decompensated Heart Failure
Interventions: DRUG: TRV027 Dose #1|DRUG: TRV027 Dose #2|DRUG: TRV027 Dose #3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: M7824 in Treating Patients With Stage II-III HER2 Positive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8
Interventions: DRUG: Bintrafusp Alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Long-Term Use of Proton-Pump-Inhibitors in General Practice
Status: UNKNOWN
Conditions: Dyspepsia|Gastroesophageal Refluxdisease|Ulcer
Interventions: DRUG: esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Doxycycline Effects on Inflammation in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Doxycycline|OTHER: No doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Prognostic Role and Diagnostic Efficacy of Exercise Right Heart Catheterization With a Simultaneous Echocardiography in Patients With Dyspnea on Exertion
Status: RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction|Chronic Pulmonary Thromboembolism (Disorder)
Interventions: DIAGNOSTIC_TEST: Exercise hemodynamic test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Low-level Laser Therapy as an Adjunct to Non-surgical Periodontal Treatment
Status: COMPLETED
Conditions: Periodontal Diseases|Periodontal Attachment Loss|Periodontal Disease, AVDC Stage 3|Periodontal Inflammation|Periodontal Disease, AVDC Stage 4
Interventions: PROCEDURE: low level laser therapy|PROCEDURE: non-surgical periodontal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Pharmacokinetics Study of ART-123 in Disseminated Intravascular Coagulation (DIC) Subjects With Renal Impairment
Status: COMPLETED
Conditions: Disseminated Intravascular Coagulation
Interventions: DRUG: ART-123
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigational Immunotherapy Study of BMS-986288 Alone and in Combination With Nivolumab in Advanced Solid Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Cancer
Interventions: DRUG: BMS-986288|DRUG: Nivolumab|DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study STF115287, a Clinical Confirmation Study of GSK2585823 in the Treatment of Acne Vulgaris in Japanese Subjects
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: GSK2585823(CLDM 1%-BPO 3% gel)|DRUG: CLDM 1% gel twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study Between Two Oral Formulations of Naproxen 500 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Bioequivalency
Interventions: DRUG: Naproxen Tablets, 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Secondary Prophylaxis of CMV Infection Using Letermovir After HID-HSCT
Status: NOT_YET_RECRUITING
Conditions: To Evaluate the Efficacy and Safety of Secondary Prophylaxis of CMV Reactivation
Interventions: DRUG: Letermovir for secondary prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Weekly Docetaxel Versus Pemetrexed in Previously Treated Advanced Non-Small-Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: docetaxel|DRUG: pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 30-to-90 Day Challenge: Effects of Alcohol Cessation on Health Outcomes
Status: COMPLETED
Conditions: Alcohol Drinking|Chronic Inflammation|Neurocognitive Dysfunction|Liver Diseases|HIV Infections
Interventions: BEHAVIORAL: Contingency Management (CM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impact of Preop Video on Patient Anxiety
Status: RECRUITING
Conditions: Prolapse, Vaginal|Prolapse, Uterine|Prolapse; Female
Interventions: OTHER: Educational Video|OTHER: Standard Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Laser Therapy Versus Narrow Band Ultraviolet B for the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Skin Diseases
Interventions: DEVICE: Narrow band ultraviolet B.|DRUG: topical erythromycin cream 2% (Akne-Mycin- Egypt)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized-controlled Trial of Social Norm Interventions to Increase Physical Activity
Status: COMPLETED
Conditions: Physical Activity
Interventions: BEHAVIORAL: Descriptive Social Norm|BEHAVIORAL: Descriptive-plus-Injunctive Social Norm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: 3-day vs. 1-day Low Residue Diet Influence in Colonoscopy Preparation and Patient Tolerability
Status: COMPLETED
Conditions: Colon Disease|Colonic Neoplasms
Interventions: OTHER: 3 day low residue diet prior to the colonoscopy|OTHER: 1 day low residue diet prior to the colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC