pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: P3 Study Comparing Once Daily SB204 and Vehicle Gel in Acne
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: SB204 4%|DRUG: Vehicle Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transplanting Hepatitis C Positive Organs
Status: RECRUITING
Conditions: Hepatitis C|Awaiting Organ Transplant
Interventions: DRUG: Sofosbuvir/velpatasvir|OTHER: Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Trial Comparing Two Dose-dense, Dose-intensified Approaches (ETC and PM(Cb)) for Neoadjuvant Treatment of Patients With High-risk Early Breast Cancer (GeparOcto)
Status: COMPLETED
Conditions: Tubular Breast Cancer Stage II|Tubular Breast Cancer Stage III|Mucinous Breast Cancer Stage II|Breast Cancer Female NOS|Invasive Ductal Breast Cancer|HER2 Positive Breast Cancer|Inflammatory Breast Cancer
Interventions: DRUG: non-pegylated liposomal doxorubicin|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: Pertuzumab|DRUG: Trastuzumab|DRUG: Ferric carboxymaltose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 5-FU, Leucovorin, Oxaliplatin and Docetaxel (FLOT) Versus Epirubicin, Cisplatin and 5-FU (ECF) in Patients With Locally Advanced, Resectable Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: 5-Fluorouracil|DRUG: Leucovorin|DRUG: Oxaliplatin|DRUG: Docetaxel|DRUG: Epirubicin|DRUG: Cisplatin|DRUG: 5-fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Health Effects of Cetoleic Acid (A Randomized Double Blinded Controlled Trial)
Status: ENROLLING_BY_INVITATION
Conditions: Healthy Diet
Interventions: DIETARY_SUPPLEMENT: Cetoleic acid|DIETARY_SUPPLEMENT: Control Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Occlusal Contact Trueness Affected by Six Chairside CAD/CAM Ceramic Materials
Status: COMPLETED
Conditions: Tooth Defect
Interventions: OTHER: Chairside CAD/CAM ceramic materials for dental restoration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparascopic Sleeve Gastrectomy vs. Endoscopic Gastric Plication in Obesity
Status: NOT_YET_RECRUITING
Conditions: Obesity
Interventions: DEVICE: laparoscopic sleeve gastrectomy|OTHER: conservative treatment of obesity|DEVICE: endoscopic gastric plication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioness® StimRouter™ Neuromodulation System for Chronic Pain Therapy
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DEVICE: StimRouter - active stimulation|DEVICE: StimRouter - Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Glecaprevir (GLE)/Pibrentasvir (PIB) in Treatment-Naive Adults With Chronic Hepatitis C Virus (HCV) Genotype 1-6 Infection and Compensated Cirrhosis
Status: COMPLETED
Conditions: Hepatitis C Virus (HCV)
Interventions: DRUG: Glecaprevir/Pibrentasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Smokeless Tobacco Products With Lower Nicotine Levels to Reduce Negative Effects of Smokeless Tobacco Use
Status: COMPLETED
Conditions: Tobacco Use Disorder
Interventions: OTHER: Lower Nicotine Smokeless Tobacco Product|OTHER: Behavioral Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Amygdala Retraining With Mindfulness (ART+MF) vs Compassion Therapy (CT) for the Treatment of Patients With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: BEHAVIORAL: ART with Mindfulness|BEHAVIORAL: Mindfulness Compassion|BEHAVIORAL: Relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neural Connectivity During Therapy for Adolescent PTSD
Status: RECRUITING
Conditions: PTSD|Adolescent|Psychological Trauma
Interventions: BEHAVIORAL: TF-CBT|BEHAVIORAL: TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Preclinical Research of mμSORS for Noninvasive Blood Glucose Detection
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes|Medical Device
Interventions: DEVICE: Multi-channel Microspatial Offset Raman Scattering Spectroscopy (mμSORS) for Noninvasive Blood Glucose Detection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dose Ranging Study of the Safety and Efficacy of R115966 in Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Talarozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multifocal High ADD Contact Lens Proof of Concept Trial
Status: COMPLETED
Conditions: Presbyopia
Interventions: DEVICE: Lotrafilcon B multifocal contact lenses (new)|DEVICE: Lotrafilcon B multifocal contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vestibular Implantation in Older Adults
Status: RECRUITING
Conditions: Other Disorders of Vestibular Function, Bilateral|Bilateral Vestibular Deficiency (BVD)|Gentamicin Ototoxicity|Labyrinth Diseases|Vestibular Diseases|Sensation Disorders|Bilateral Vestibular Hypofunction|Bilateral Vestibulopathy|Presbyvestibulopathy|Aminoglycoside Ototoxicity
Interventions: DEVICE: Labyrinth Devices MVI™ Multichannel Vestibular Implant System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Eight-week Study of SSR411298 as Treatment for Major Depressive Disorder in Elderly Patients
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: SSR411298|DRUG: Escitalopram|DRUG: Placebo (for SSR411298)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: New Clinical Outcome Measures to Remotely Evaluate Patients With FacioScapuloHumeral Muscular Dystrophy
Status: RECRUITING
Conditions: Type 1 Facioscapulohumeral Muscular Dystrophy
Interventions: OTHER: Remote monitoring program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Nitroglycerin to Facilitate Radial Arterial Catheter Insertion in Children
Status: COMPLETED
Conditions: Radial Artery Canulation
Interventions: DRUG: NTG patch|OTHER: gauze cover
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Whole Food for Families: A Pilot RCT of a Dietary Guidelines-Based Intervention to Prevent Type 2 Diabetes
Status: NOT_YET_RECRUITING
Conditions: PreDiabetes|Diet, Healthy|Nutritional and Metabolic Diseases
Interventions: BEHAVIORAL: Whole Foods for Families
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Utility of Perfusion MRI to Detect Radiation Necrosis in Patients With Brain Metastases
Status: COMPLETED
Conditions: Invasive Malignant Neoplasm|Metastatic Malignant Neoplasm in the Brain
Interventions: PROCEDURE: Dynamic Susceptibility Contrast-MRI (DSC-MRI)|PROCEDURE: Magnetic Resonance Imaging (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Tolerability of SPD476 in Maintaining Remission in Patients With Ulcerative Colitis.
Status: COMPLETED
Conditions: Colitis, Ulcerative
Interventions: DRUG: SPD476 (mesalazine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigation Into the Effect of Liquorice Ingestion on the Salivary Cortisol to Cortisone Molar Ratio
Status: COMPLETED
Conditions: Apparent Mineralocorticoid Excess
Interventions: DIETARY_SUPPLEMENT: Liquorice
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The HEALS Project - Health Education and Active Living for Surviving Seniors
Status: COMPLETED
Conditions: Cancer Survivorship|Safety and Efficacy|Quality of Life
Interventions: BEHAVIORAL: Tai Chi Chih|BEHAVIORAL: Health Education Classes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Prospective, Randomized, Single-blinded (Evaluator), Parallel, Multi-center, Phase 3 Trial in Bowel Preparation for Colonoscopy
Status: COMPLETED
Conditions: Bowel Preparation
Interventions: DRUG: TJP-008-1|DRUG: TJP-008-2|DRUG: Coolprep powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of an Intervention Using Observation/Action Therapy Among Patients With Mild Cognitive Impairment
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Age-associated Memory Impairment
Interventions: OTHER: Action observation training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Community Psychosocial Intervention for Women
Status: COMPLETED
Conditions: Mental Health Wellness 1|Psychological Distress|Coping Skills|Stress
Interventions: BEHAVIORAL: Entre Nosotras|BEHAVIORAL: Doing What Matters in Times of Stress
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study on Laparoscopic D2 Lymphadenectomy Plus Complete Mesogastrium Excision（D2+CME）for Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: PROCEDURE: Laparoscopic D2 lymphadenectomy plus CME|PROCEDURE: Laparoscopic D2 lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Randomized Controlled Trial of Imago Relationship Therapy
Status: COMPLETED
Conditions: Relationship Disorder
Interventions: BEHAVIORAL: Imago Relationship Therapy|BEHAVIORAL: Waitlist with Bibliotherapy followed by Workshop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate Bronchial Arterrial Infusing (BAI) Plus Three-dimensional Conformal Radiotherapy (3DCRT) in Local Advanced Non-small Cell Lung Cancer (NSCLC)
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Gemcitabine, Nedaplatin, iV|RADIATION: 3DCRT|RADIATION: 3DCRT|DRUG: Gemcitabine，Nedaplatin, BAI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of the Distribution to Attending Physicians of a Nominative List of Their Patients Not Participating in the Organised Screening of Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: OTHER: Providing a list of patients not compliant with CRC sreening|OTHER: Providing general information about CRC sreening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intra-aortic Balloon Counterpulsation in Patients Undergoing Cardiac Surgery
Status: UNKNOWN
Conditions: Postoperative; Dysfunction Following Cardiac Surgery
Interventions: DEVICE: Intra-aortic balloon pump.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supporting Patient Care With Electronic Resource (SuPER)
Status: UNKNOWN
Conditions: Arthritis, Rheumatoid
Interventions: BEHAVIORAL: ANSWER-2 decision aid|BEHAVIORAL: Control Group (TAS Consumer Guide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oncolytic Virotherapy Plus PD-1 Inhibitor for Patients With Refractory Malignant Ascites
Status: RECRUITING
Conditions: Refractory Malignant Ascites
Interventions: DRUG: H101|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exercise Endurance Study to Evaluate the Effects of Treatment of Chronic Obstructive Pulmonary Disease (COPD) Patients With a Dual Bronchodilator: GSK573719/GW642444. Study A
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK 573719 +GW642444 125/25|DRUG: GSK573719 + GW642444 62.5/25|DRUG: GSK 573719 125|DRUG: GSK 573719 62.5|DRUG: GW642444 25|DRUG: Plb
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Belimumab in the Treatment of Non-infectious Active Cryoglobulinemia Vasculitis Compared to Placebo. TRIBECA STUDY (Treatment nd BElimumab in Cryoglobulinemia Associated Vasculitis)
Status: RECRUITING
Conditions: Vasculitis|Cryoglobulinemia
Interventions: DRUG: Belimumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Adverse Events, Change in Disease Activity, and How the Drug Moves Through the Body in Children With Juvenile Psoriatic Arthritis (jPsA) Receiving Subcutaneously Injected Risankizumab or Adalimumab
Status: RECRUITING
Conditions: Juvenile Psoriatic Arthritis
Interventions: DRUG: Adalimumab|DRUG: Risankizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Personalized mRNA Vaccine Encoding Neoantigen in Patients With Advanced Digestive System Neoplasms
Status: UNKNOWN
Conditions: Advanced Esophageal Squamous Carcinoma|Gastric Adenocarcinoma|Pancreatic Adenocarcinoma|Colorectal Adenocarcinoma
Interventions: BIOLOGICAL: Personalized mRNA Tumor Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Therapeutic Approach in Upper Limb Lymphedema Secondary to Breast Cancer: Activity-oriented Proprioceptive Antiedema Therapy (TAPA)
Status: COMPLETED
Conditions: Breast Cancer Lymphedema|Post-Mastectomy Secondary Lymphedema
Interventions: OTHER: Activity-oriented Proprioceptive Antiedema Therapy (TAPA)|OTHER: Complete Decongestive Therapy (CDT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel + Doxorubicin as Neoadjuvant Chemotherapy in Patients With Breast Cancer
Status: TERMINATED
Conditions: Ductal Carcinoma
Interventions: DRUG: Docetaxel|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Pelvic Organ Prolapse Repair Using Transvaginal Mesh
Status: COMPLETED
Conditions: Pelvic Organ Prolapse
Interventions: DEVICE: Transvaginal mesh- PROLIFT®-system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Corticosteroid Therapy and Rituximab to Prevent Generalization in Ocular Myasthenia: a PROBE Multicenter Open-label Randomized Controlled Trial.
Status: NOT_YET_RECRUITING
Conditions: Ocular Myasthenia Gravis
Interventions: DRUG: immediate treatment with corticosteroids|DRUG: addition of rituximab if recurrence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Macrolide Maintenance Therapy in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Azithromycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Safety and Immune Response to a Live H7N9 Influenza Virus Vaccine Followed by an Inactivated H7N9 Influenza Virus Vaccine, Given at Varying Intervals
Status: COMPLETED
Conditions: Influenza A Virus, H7N9 Subtype
Interventions: BIOLOGICAL: H7N9 A/Anhui/13 ca influenza virus vaccine|BIOLOGICAL: Inactivated subvirion H7N9 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ready to Use Therapeutic Food (RUTF) in Severe Malnourished Children
Status: COMPLETED
Conditions: Severe Acute Malnutrition
Interventions: DIETARY_SUPPLEMENT: Plumpy Nut|DIETARY_SUPPLEMENT: Khichuri and Halwa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase III Trial of Coenzyme Q10 in Mitochondrial Disease
Status: COMPLETED
Conditions: Mitochondrial Diseases
Interventions: DRUG: CoenzymeQ10|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bone Mass and Strength After Kidney Transplantation
Status: COMPLETED
Conditions: End Stage Renal Disease|Kidney Transplantation|Bone Loss|Fractures|Vascular Calcifications
Interventions: DRUG: Vitamin D3|DRUG: Calcitriol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy and Safety of Using Intralesional 5-fluorouracil for Basal Cell Carcinoma
Status: RECRUITING
Conditions: Basal Cell Carcinoma|BCC
Interventions: DRUG: 5-Fluorouracil|OTHER: SURGERY
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine and Morphine as Adjuvants to US Guided Erector Spinae Plane Blocks in Elective Thoracic Surgeries
Status: NOT_YET_RECRUITING
Conditions: Pain, Postoperative|Pain, Acute|Pain, Chronic|Morphine|Dexmedetomidine|Analgesia
Interventions: DRUG: erector spinae plane block with a combination of ropivacaine and morphine|DRUG: erector spinae plane block with a combination of ropivacaine and dexmedetomidine|DRUG: erector spinae plane block with ropivacaine only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Screening of ATTRwt in Patient With Advanced AV-Block Undergoing Pacemaker Implantation
Status: RECRUITING
Conditions: Amyloid Cardiomyopathy|Block, AV
Interventions: DIAGNOSTIC_TEST: Amyloidosis screening (bloodtest, DPD-scintigraphy, potentially endomyocardial biopsy)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Therapeutic Approaches for Subjects With Scapula Dyskinesis
Status: COMPLETED
Conditions: Shoulder Impingement
Interventions: OTHER: Conscious control|OTHER: Conscious control+biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: China Adrenal Disease Registry
Status: RECRUITING
Conditions: Cushing Syndrome|Aldosteronism|Hypoadrenalism|Congenital Adrenal Hyperplasia|Adrenal Adenoma|Adrenal Incidentaloma|Adrenal Carcinoma|Pheochromocytoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open-Label, Safety and Tolerability Extension Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS) (CL211)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: KNS-760704
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Novel Reconstruction Device for Osteonecrotic Femoral Head Efficacy Evaluation
Status: COMPLETED
Conditions: Osteonecrosis
Interventions: PROCEDURE: Core Decompression|PROCEDURE: Osteonecrotic Repair Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Performance of INVICTA Ventricular DF4 LEADS With Active Fixation-(APOLLO)
Status: ACTIVE_NOT_RECRUITING
Conditions: Ventricular Arrythmia|Lead|ICD|Heart Failure
Interventions: DEVICE: INVICTA lead
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of HMG-CoA Reductase Inhibition on Postprandial GLP-1 Secretion
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Hydroxymethylglutaryl-CoA Reductase Inhibitors
Interventions: DRUG: Atorvastatin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sensorimotor Stimulation, Routine Physical Therapy, Balance, Cognitive Performance Mild Traumatic Brain Injury Patients
Status: UNKNOWN
Conditions: Mild Traumatic Brain Injury
Interventions: OTHER: Routine physical therapy+ Sensorimotor stimulation|OTHER: Routine physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ai Youmian (Love Better Sleep) for People Living With HIV
Status: COMPLETED
Conditions: Sleep|HIV Infections
Interventions: BEHAVIORAL: 8-week interpersonal and social rhythm intervention|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Shared Decision-making to Guide Care for People With Dementia and Diabetes
Status: RECRUITING
Conditions: Diabetes|Alzheimer's Disease (Incl Subtypes)|Dementia|Hypoglycemia
Interventions: DEVICE: Continuous Glucose Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sildenafil for Microvasculopathy in Chronic TBI
Status: RECRUITING
Conditions: Traumatic Brain Injury
Interventions: DRUG: Sildenafil Citrate low dose|DRUG: Placebo|DRUG: Sildenafil medium dose|DRUG: Sildenafil high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proximal Medial Gastriocnemius Recession for Chronic Plantar Fasciitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Plantar Fasciitis
Interventions: PROCEDURE: Proximal Medial Gastrocnemius Recession
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Aclidinium/Formoterol on Lung Hyperinflation, Exercise Capacity and Physical Activity in Moderate to Severe COPD Patients
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Aclidinium/Formoterol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-comparative Evaluation of Facial Expressions Following Lower Face Correction Using Emervel Classic and Emervel Deep
Status: COMPLETED
Conditions: Nasolabial Folds|Wrinkles
Interventions: DEVICE: Emervel Classic|DEVICE: Emervel Deep
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regenerative Endodontic Therapy (RET) for the Management of Immature Non-vital Permanent Teeth in Children
Status: COMPLETED
Conditions: Infected Immature Permanent Teeth
Interventions: DRUG: RET using antibiotics (Ciprofloxacin and Metronidazole)|DRUG: RET using non-setting Calcium Hydroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of PB127 Ultrasound Contrast Agent in Patients With Suspected Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: PB127 for injectable suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Combined Levothyroxine/Liothyronine Supplementation in Hypothyroid Patients With Brain Tumors
Status: TERMINATED
Conditions: Hypothyroidism|Brain Tumor
Interventions: DRUG: Levothyroxine|DRUG: Liothyronine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allergen Challenge Chamber Study With Single Dose Oral GSK835726 Compared With Placebo
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal
Interventions: DRUG: GSK835726 (10mg)|DRUG: GSK835726 (50mg)|DRUG: GSK835726 (100mg)|DRUG: Cetirizine (10mg)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Spinal, Cortical, and Sensorimotor Biomarkers in Motor Neurone Disease
Status: RECRUITING
Conditions: Motor Neuron Disease, Amyotrophic Lateral Sclerosis|Motor Neuron Disease Progressive Spinal Muscle Atrophy|Primary Lateral Sclerosis|Multiple Sclerosis|Postpoliomyelitis Syndrome
Interventions: PROCEDURE: 232 Electrode Electrophysiology (EEG-ECG-EMG-EXG)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Combination Osimertinib and Ipilimumab in Patients w EGFR Mutated NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor (Disorder)
Interventions: DRUG: Ipilimumab|DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized I/II Phase Study of ALZT-OP1 Combination Therapy in Alzheimer's Disease and Normal Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers|Alzheimer Disease
Interventions: DRUG: ALZT-OP1 (cromolyn and ibuprofen) ALZT-OP1a (cromolyn) and ALZT-OP1b (ibuprofen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Nasotracheal Tubes on Tube Passage
Status: COMPLETED
Conditions: Sialolithiasis
Interventions: DEVICE: nasotracheal tube (Ring-Adair-Elwin)|DEVICE: nasotracheal tube (Ring-Adair-Elwin)|DEVICE: nasotracheal tube (portex)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: EUS-FNI for MEN1-related Pancreatic Neuroendocrine Tumors
Status: RECRUITING
Conditions: Multiple Endocrine Neoplasia Type 1|Pancreatic Neuroendocrine Tumor
Interventions: PROCEDURE: EUS-guided fine-needle injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Camostat Mesilate Treating Patients With Hospitalized Patients With COVID-19
Status: RECRUITING
Conditions: Severe Acute Respiratory Syndrome
Interventions: DRUG: Camostat Mesilate|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery
Status: RECRUITING
Conditions: Adult Spinal Deformity|Scoliosis|Kyphosis|Sagittal Imbalance
Interventions: PROCEDURE: Index or spine revision surgery for complex adult spinal deformity
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence Study of Fingolimod From Sphingomod 0.5 mg Hard Gelatin Capsules (Hikma Pharma, Egypt) Versus Gilenya 0.5 mg Hard Capsules (Novartis Pharma AG, Basle, Switzerland).
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Sphingomod|DRUG: Gilenya
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: RCT to Investigate Whether an Exercise Programme Improves the Physical Performance and QOL After BMT
Status: UNKNOWN
Conditions: Hematological Malignancies
Interventions: PROCEDURE: aereobic plus resisted exercise|PROCEDURE: aerobic plus active exercise|OTHER: No formal exercise plus phone calls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ONC201 and Radiation Therapy Before Surgery for the Treatment of Recurrent Glioblastoma
Status: WITHDRAWN
Conditions: Recurrent Glioblastoma|Recurrent Gliosarcoma|Recurrent Supratentorial Glioblastoma|Supratentorial Gliosarcoma
Interventions: DRUG: Akt/ERK Inhibitor ONC201|RADIATION: Radiation Therapy|PROCEDURE: Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exhaled Breath Analysis to Predict Risk of Symptomatic Pneumonitis
Status: TERMINATED
Conditions: Pneumonitis|Nonsmall Cell Lung Cancer Stage III
Interventions: OTHER: Exhaled Breath Collection|OTHER: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Laryngeal Tube vs Laryngeal Mask Airway
Status: COMPLETED
Conditions: Cardiac Arrest
Interventions: DEVICE: Laryngeal Mask Airway (LMA)|DEVICE: Laryngeal Tube (LT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Skin Prep to Reduce Postoperative Shoulder Infection
Status: COMPLETED
Conditions: Shoulder Infection
Interventions: DRUG: Skin Prep Chlorhexidine|DRUG: Skin Prep Benzoyl Peroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Pilot Study To Evaluate the Effect of Retrovir (Zidovudine: AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Associated Dementia and Neuromuscular Diseases
Status: COMPLETED
Conditions: AIDS Dementia Complex|Neuromuscular Diseases|HIV Infections
Interventions: DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Impact of Cancer Treatment on the Pelvic Floor Function in Survivors of Cervical Cancer
Status: UNKNOWN
Conditions: Cervical Cancer|Pelvic Floor Disorders|Surgery|Radiotherapy; Complications|Chemotherapy Effect
Interventions: OTHER: Assessment of the pelvic floor function|OTHER: Questionnaire application
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: α-ketoglutarate in Patients With Hypertension
Status: RECRUITING
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Alpha-ketoglutarate supplied as 1000mg capsule|BEHAVIORAL: Behavioral: Lifestyle modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Er,Cr:YSGG and Diode Lasers In Second Stage Implant Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Soft Tissue Bleeding|Wound Heal
Interventions: DEVICE: 940 nm Gallium Aluminum Arsenide Diode Laser|DEVICE: 2780 nm Er,Cr:YSGG Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotics (Vivomixx®) on Weight, Microbiota and Glucose Tolerance in Obese Pregnant Women and Their Newborn
Status: COMPLETED
Conditions: Pregnancy|Obesity|Gestational Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Vivomixx®|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Fish Oil on Hyperlipidemia and Toxicities in Children and Young Adults With Acute Lymphoblastic Leukemia
Status: RECRUITING
Conditions: Leukemia, Acute Lymphoblastic
Interventions: DIETARY_SUPPLEMENT: Eskimo-3 Pure Fish Oil|DIETARY_SUPPLEMENT: Rapeseed Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Epidural Anesthesia on the Bioavailability of Nitric Oxide and Renal Function in Patients Undergoing Laparoscopic Surgery
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: Epidural anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Varenicline Safety, Tolerability, Pharmacokinetics and Pro-Cognitive Effects in Healthy Elderly Non-Smoking Subjects
Status: COMPLETED
Conditions: Healthy|Non-Smoking
Interventions: DRUG: varenicline|DRUG: varenicline|DRUG: varenicline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Intrathecal Methotrexate for Progressive Multiple Sclerosis: An Open Label Single Arm Study
Status: UNKNOWN
Conditions: To Evaluate the Effect of Therapy With IT MTX on the Disease Course of Patients With Progressive MS
Interventions: DRUG: Intrathecal methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enzalutamide in Androgen Deprivation Therapy With Radiation Therapy for High Risk, Clinically Localised, Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostatic Neoplasms
Interventions: DRUG: Enzalutamide|DRUG: Conventional NSAA|DRUG: LHRHA|RADIATION: External Beam Radiotherapy (78 Gy in 39 fractions or 46 Gy in 23 fractions plus brachytherapy boost)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of BKM120/Tamoxifen-combination in Patients With HR-pos, HER2-neg Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: BKM120|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Institutes Experience in Laparo-Endoscopic Rendezvous Technique for Gallbladder and Bile Duct Stones
Status: COMPLETED
Conditions: Calculus; Gallbladder, With Cholecystitis
Interventions: PROCEDURE: The intraoperative ERCP has been performed immediately before LC|PROCEDURE: POES followed by LC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Treatment of Patients With Major Depressive Disorder With MK0869 (0869-063)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: MK0869, aprepitant|DRUG: Comparator: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intralesional Rituximab for the Treatment of Conjunctival Indolent Lymphoma
Status: COMPLETED
Conditions: Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma
Interventions: DRUG: intralesional rituximab|BIOLOGICAL: supplemental autologous serum
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose-Ranging Clinical Study to Assess the Safety and Efficacy of Subconjunctival Injection of Sirolimus in Patients With Dry Eye in the Controlled Adverse Environmental (CAE) Model
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Sirolimus|DRUG: Sirolimus|DRUG: Sirolimus|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Mobilizations and Exercises Targeting the Opening of Intervertebral Foramens Following Cervical Radiculopathy
Status: COMPLETED
Conditions: Radiculopathy
Interventions: PROCEDURE: Program targeting the opening of foramen|PROCEDURE: Conventional Rehabilitation Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Very Low Calories Ketogenic Diet in Obese Patients With Fibromyalgia or Symptomatic Knee Osteoarthritis
Status: RECRUITING
Conditions: Fibromyalgia|Knee Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: Very low-calorie ketogenic diet for patients with symptomatic knee osteoarthritis|DIETARY_SUPPLEMENT: Very low-calorie ketogenic diet for patients with fibromyalgia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimized Caloric-proteic Nutrition in Septic and Septic Shock Patients
Status: TERMINATED
Conditions: Sepsis|Septic Shock
Interventions: OTHER: Peptamen intense|OTHER: Novasource senior
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2, Pharmacokinetic (PK) Study of 6R-BH4 Alone or 6R-BH4 With Vitamin C in Subjects With Endothelial Dysfunction
Status: COMPLETED
Conditions: Endothelial Dysfunction
Interventions: DRUG: Sapropterin Dihydrochloride|DRUG: Sapropterin Dihydrochloride and Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxyurea for Children and Young Adults With Sickle Cell Disease and Pulmonary Hypertension
Status: TERMINATED
Conditions: Sickle Cell Disease|Pulmonary Hypertension
Interventions: DRUG: Hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sotrastaurin Acetate in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, Prolymphocytic Leukemia, or Richter's Transformation
Status: WITHDRAWN
Conditions: Prolymphocytic Leukemia|Recurrent Mantle Cell Lymphoma|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Richter Syndrome
Interventions: DRUG: sotrastaurin acetate|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acalabrutinib (ACP-196) Alone and in Combination With Pembrolizumab in Ovarian Cancer (KEYNOTE191)
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Acalabrutinib|DRUG: acalabrutinib and pembrolizumab combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-operative Voiding Dysfunction: the Preferred Method for Catheterization
Status: UNKNOWN
Conditions: Voiding Dysfunction After Pelvic Organ Prolapse Surgery
Interventions: PROCEDURE: CISC instruction pre-operatively
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Supralimus-Core™ Pharmacokinetic (PK) Study
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Supralimus-Core™ Sirolimus eluting Coronary Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heme Arginate in Transplantation Study
Status: TERMINATED
Conditions: Renal Transplant Rejection|Renal Transplant Failure
Interventions: DRUG: Heme Arginate 25 MG/ML|DRUG: 0.9% Sodium-chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Respiratory Therapy and Newborn Pain: Comparison Between Techniques
Status: COMPLETED
Conditions: Newborn Pain|Respiratory Therapy Techniques
Interventions: PROCEDURE: Thoracoabdominal rebalancing|PROCEDURE: Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Relationship Between the Growth Hormone (GH)- Insulin Like Growth Factor I (IGF-I) System and the Inflammatory System in Healthy Normal Persons
Status: UNKNOWN
Conditions: Interaction Between the GH/IGF-I System and the Immune-system
Interventions: DRUG: Somatropin|DRUG: Pegvisomant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Salutogenic Approach Based Interview With People With Schizophrenia
Status: COMPLETED
Conditions: Salutogenesis|Mental Health Disorder|Schizophrenia|Sense of Coherence
Interventions: BEHAVIORAL: Salutogenic Approach Based Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Trifluridine/Tipiracil in Triple Negative Metastatic Breast Cancer
Status: WITHDRAWN
Conditions: Metastatic Triple Negative Breast Cancer
Interventions: DRUG: Trifluridine/Tipiracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contrast Enhancement on Coronary Computed Tomographic Angiography
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Stenosis
Interventions: DRUG: 240 mg Iodine|DRUG: 300 mg Iodine|DRUG: 370 mg Iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Short-term Oral Prednisone for Acute Subjective Tinnitus
Status: COMPLETED
Conditions: Tinnitus, Subjective
Interventions: DRUG: Prednisone tablet|DRUG: Ginkgo Biloba Extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Stimulation of STN and SNr for Resistant Freezing of Gait in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: PROCEDURE: [standard STN]|PROCEDURE: [STN+SNr]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Carbohydrate-rich Diet in Healthy Subjects
Status: COMPLETED
Conditions: Lipid Metabolism Disorder
Interventions: DIETARY_SUPPLEMENT: isocaloric diet|DIETARY_SUPPLEMENT: Hypercaloric diet|OTHER: Liquid meal|RADIATION: PET imaging|OTHER: perfusions of stable tracers|DEVICE: Indirect calorimetry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: |Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Patients With High-Risk Muscle-Invasive Bladder Cancer Who Are ctDNA Positive Following Cystectomy
Status: RECRUITING
Conditions: Muscle-invasive Bladder Cancer
Interventions: DRUG: Atezolizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies
Status: RECRUITING
Conditions: Adverse Childhood Experiences|Vascular Dilatation|Sleep|Sleep Disturbance|Psychosocial Stressor|Psychological Trauma|Endothelial Dysfunction|Inflammation|Oxidative Stress
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia (CBT-i)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Community Resilience Learning Collaborative and Research Network
Status: COMPLETED
Conditions: Depression|Social Stress|Anxiety|Quality of Life|Disaster
Interventions: OTHER: Technical Assistance|OTHER: Community Engagement and Planning|OTHER: Community Resources (CR)|OTHER: Community Resources + eBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH