pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety of Atenas Association in the Treatment of Type II Diabetes Mellitus and Hypertension
Status: WITHDRAWN
Conditions: Hypertension Associated|Type II Diabetes Mellitus
Interventions: DRUG: Atenas|DRUG: Atenas placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Demineralized Dentin Graft in Preservation of Post-Extraction Sites Associated With Delayed Implant Placement
Status: ACTIVE_NOT_RECRUITING
Conditions: Socket Preservation
Interventions: PROCEDURE: socket preservation with completely demineralized dentin graft|PROCEDURE: socket preservation with partially demineralized dentin graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Temsirolimus and Brentuximab Vedotin in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma
Status: COMPLETED
Conditions: Recurrent Adult Hodgkin Lymphoma
Interventions: DRUG: Brentuximab Vedotin|OTHER: Laboratory Biomarker Analysis|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epothilone ZK-219477 in Treating Patients With Recurrent Glioblastoma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: sagopilone|GENETIC: fluorescence in situ hybridization|GENETIC: gene expression analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Canakinumab for the Prevention of Recurrences After Electrical Cardioversion: CONVERT-AF
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: BIOLOGICAL: Canakinumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan and Carboplatin in Treating Patients With Metastatic or Recurrent Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: V501 Efficacy Study in Women Aged 18 to 26 (V501-027)
Status: COMPLETED
Conditions: HPV Infections
Interventions: BIOLOGICAL: Quadrivalent Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine|BIOLOGICAL: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Platelet Rich Fibrin Treatment for the Alveolar Ridge Preservation in Smokers
Status: RECRUITING
Conditions: Alveolar Process Atrophy|Smoking, Cigarette|Platelet-Rich Fibrin
Interventions: OTHER: Autologous Leukocyte and platelet-rich fibrin|OTHER: Intraoral Scan|RADIATION: Computed Tomography|OTHER: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2
Status: COMPLETED
Conditions: Cardiovascular Disease|Healthcare Associated Infectious Disease|Sternal Superficial Wound Infection|Deep Sternal Infection|Mediastinitis|Thoracotomy|Conduit Harvest or Cannulation Site|Sepsis|Pneumonia
Interventions: OTHER: There is no intervention. The investigators are interviewing cardiac surgery staff with knowledge of infection prevention.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Potential Role of n-3 Fatty Acids in the Treatment of NAFLD in Pediatric Patients
Status: UNKNOWN
Conditions: Non Alcoholic Fatty Liver Disease (NAFLD)
Interventions: DIETARY_SUPPLEMENT: omega 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Efficacy of AIN457 in Patients With Uncontrolled Asthma
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: AIN457 (secukinumab)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Meta-Analysis of Stress Myocardial Perfusion Imaging
Status: COMPLETED
Conditions: Coronary Disease|Echocardiography|Fractional Flow Reserve, Myocardial|Hemodynamics|Humans|Magnetic Resonance Imaging|Myocardial Perfusion Imaging|Perfusion|Predictive Value of Tests|Single Photon Emission Computed Tomography|Positron Emission Tomography|Multidetector Computed Tomography|Echocardiography, Stress|Coronary Angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate the Safety and Efficacy of CAT-354
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: Placebo|BIOLOGICAL: CAT-354 150 mg|BIOLOGICAL: CAT-354 300 mg|BIOLOGICAL: CAT-354 600 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Doxycycline and TUDCA in Patients With Transthyretin Amyloid Cardiomyopathy
Status: COMPLETED
Conditions: Amyloidosis; Heart (Manifestation)|Senile Cardiac Amyloidosis
Interventions: DRUG: Tauroursodeoxycholic Acid and Doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: (SWL) Versus (ODT) Versus Combined SWL And ODT For Radiolucent Stone
Status: COMPLETED
Conditions: Urologic Diseases|Stone, Urinary|Stone, Kidney|ESWL|Radiolucent Calculus of Urinary Tract|Dissolution
Interventions: PROCEDURE: Ultrasound guided SWL|PROCEDURE: Dissolution therapy|PROCEDURE: Combined ultrasound guided SWL and dissolution therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Phase II/III, Placebo-Controlled Study of SNX-111 Administered Intrathecally to Cancer and AIDS Patients With Chronic Pain
Status: COMPLETED
Conditions: HIV Infections|Cancer|Pain
Interventions: DRUG: Ziconotide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Acute Effect of Fructose on Lipid Metabolism and Gender Differences
Status: COMPLETED
Conditions: Lipid Metabolism
Interventions: DIETARY_SUPPLEMENT: fructose|DIETARY_SUPPLEMENT: Fructose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Influence of PRN Dry Eye Omega-3 Nutritional Regimen on Tear Osmolarity In Cases Of Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DIETARY_SUPPLEMENT: Omega-3 (Triglyceride form)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Telerehabilitation in Continuity With Outpatient Physiotherapy After Total Hip Replacement.
Status: RECRUITING
Conditions: Total Hip Replacement|Telerehabilitation|Physiotherapy
Interventions: OTHER: Telerehabilitation|OTHER: Traditional rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Frequency and of the Regulatory Function of Positive T Lymphocytes Dual CD4CD8aa (DP8a) Specific to a Bacteria of the Intestinal Microbiota (Faecalibacterium Prausnitzii) in Atopic Dermatitis, Asthma and Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Asthma|Allergic Rhinitis|Atopic Dermatitis
Interventions: GENETIC: double positive T cells (CD4 + / CD8 +) to the specific peripheral blood of F prauznitzii analyse
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial of Non-absorbable Versus Absorbable Sutures for Trichiasis Surgery
Status: COMPLETED
Conditions: Trachomatous Trichiasis|Trachoma
Interventions: PROCEDURE: Trichiasis surgery with absorbable sutures|PROCEDURE: Trichiasis surgery with non-absorbable sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Task-oriented Progressive Resistance Strength Training and Balance Exercises on Lower Limb in Individuals With Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Task orientated strengthening training|OTHER: Balance training exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TroVax® In Subjects With Hormone Refractory Prostate Cancer (HRPC)
Status: TERMINATED
Conditions: Hormone Refractory Prostate Cancer
Interventions: DRUG: Docetaxel|DRUG: TroVax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating a Phosphatidylserine Based Dietary Approach for the Management of Mild Cognitive Impairment
Status: TERMINATED
Conditions: Mild Cognitive Impairment
Interventions: OTHER: Phosphatidylserine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Combined Open and Closed Approach for Management of Pilonidal Sinus by Special U-shaped Sutures Without Drain.
Status: COMPLETED
Conditions: Pilonidal Sinus
Interventions: PROCEDURE: open and closed approach|PROCEDURE: Rhomboid flap technique|PROCEDURE: Karydakis technique|PROCEDURE: open technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metastatic Melanoma Patients on Immunotherapy With Nutritive Intervention Based on Mediterranean Diet
Status: RECRUITING
Conditions: Melanoma Stage Iv|Metastatic Melanoma
Interventions: BEHAVIORAL: Mediterranean Diet Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Risperidone Alone Vs. Risperidone Plus Valproate in the Treatment of Patients With Schizophrenia and Hostility
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Risperidone, divalproex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: The TRUST Trial - CardioVascular Imaging ECHO
Status: COMPLETED
Conditions: Thyroid Dysfunction|Atherosclerosis|Heart Failure
Interventions: DRUG: Levothyroxine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Self-management Compared to Care-as-usual for Men With Lower Urinary Tract Symptoms
Status: ACTIVE_NOT_RECRUITING
Conditions: Lower Urinary Tract Symptoms
Interventions: DEVICE: URincontrol4men|OTHER: Care as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Daptomycin as an Adjuvant Agent in the Treatment of Enterococcal Native Valve Endocarditis.
Status: TERMINATED
Conditions: Endocarditis, Bacterial
Interventions: DRUG: Daptomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of 12 Clips in Maternal and Neoanatal Health Through Applied Neuroscience Tools (Neuromarketing Strategy)
Status: COMPLETED
Conditions: Pregnancy
Interventions: OTHER: Twelve clips regarding maternal and neonatal health topics|OTHER: Control Clip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Intrathecal Fentanyle Versus Dexamethasone in Gynacological Laparoscopic Surgeries
Status: COMPLETED
Conditions: Intraoperativ Pain
Interventions: DRUG: intrathecal fentanyle|DRUG: dexamethasone|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety of Amorphous Calcium Carbonate in RA Patient With Osteopenia or Osteoporosis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Osteopenia or Osteoporosis
Interventions: DIETARY_SUPPLEMENT: DENSITY™ (Amorphous calcium carbonate, ACC)|DIETARY_SUPPLEMENT: Crystalized calcium carbonate (CCC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Safety and Tolerability of Ocular Lubricants
Status: COMPLETED
Conditions: Dry Eye
Interventions: OTHER: NGF5-A test formulation|OTHER: NGF4-B test formulation|OTHER: NGF6-B test formulation|OTHER: NGF6-E test formulation|OTHER: Systane eye drop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a Rapid Triadic Communication Intention Elicitation Intervention to Improve Supportive Oncology Care Delivery
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage III Vulvar Cancer|Stage III Ovarian Cancer|Stage III Uterine Cancer|Stage III Vaginal Cancer|Stage IV Vulvar Cancer|Stage IV Ovarian Cancer|Stage IV Uterine Cancer|Stage IV Vaginal Cancer
Interventions: BEHAVIORAL: Intervention group triads
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ibuprofen vs. Continuous Indomethacin in the Treatment of PDA
Status: COMPLETED
Conditions: Patent Ductus Arteriosus
Interventions: DRUG: Continuous indomethacin|DRUG: ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy of LABCAT TCJUSS in Patients With Depressive Episode
Status: TERMINATED
Conditions: Depression
Interventions: DRUG: Escitalopram 10mg|DRUG: LABCAT TCJUSS|DRUG: LABCAT TCJUSS Placebo|DRUG: Escitalopram Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability, and Pharmacokinetics of HFB30132A Against COVID-19 in Chinese Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HFB30132A|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Palliative Care for Patients With ALS and Their Caregivers
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: BEHAVIORAL: Palliative Care consultation outside standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation the Palliative Effects of Colchicine on Primary Hepatic Malignant Tumors Unable to Receive Curative Treatment
Status: RECRUITING
Conditions: Hepatocellular Carcinoma Stage IIIB|Cholangiocarcinoma, Intrahepatic|Cholangiocarcinoma; With Hepatocellular Carcinoma|Hepatocellular Carcinoma Stage IV
Interventions: DRUG: Colchicine Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia
Status: RECRUITING
Conditions: Erythroplakia|Oral Leukoplakia
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Extended Release Metformin Hydrochloride|DRUG: Placebo Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Preemptive Use of Convalescent Plasma for High-risk Patients With COVID-19
Status: UNKNOWN
Conditions: Covid19|Immuno-Deficiency|Old Age; Debility
Interventions: DRUG: SARS-CoV-2 convalescent plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Optimal Dose Finding Study ABT-199 and Ibrutinib in MCL
Status: COMPLETED
Conditions: Lymphoma, Mantle-Cell|Recurrent Lymphoma, Mantle-Cell
Interventions: DRUG: ABT-199 and Ibrutinib Combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Primary or Recurrent Sarcoma
Status: WITHDRAWN
Conditions: Stage III Adult Soft Tissue Sarcoma|Recurrent Adult Soft Tissue Sarcoma|Stage IVA Adult Soft Tissue Sarcoma|Stage IIB Adult Soft Tissue Sarcoma|Stage IIC Adult Soft Tissue Sarcoma
Interventions: DRUG: doxorubicin|DRUG: filgrastim|DRUG: ifosfamide|PROCEDURE: biological response modifier therapy|PROCEDURE: brachytherapy|PROCEDURE: chemotherapy|PROCEDURE: colony-stimulating factor therapy|PROCEDURE: conventional surgery|PROCEDURE: cytokine therapy|PROCEDURE: intraoperative radiotherapy|PROCEDURE: radiation therapy|PROCEDURE: surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluating Glial Acetate Metabolism as a Biomarker of Hypoglycemic Complications in Diabetic Patients
Status: COMPLETED
Conditions: Diabetes|Hypoglycemia
Interventions: OTHER: 13C-MRS procedure/Acetate infusion|DEVICE: Continuous glucose monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: OXIRI [Oxaliplatin (O), Xeloda (X) and Irinotecan (I)] in Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: oxaliplatin, irinotecan, capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dotatate to Locate Coronary Plaques at High-risk of Myocardial Infarction
Status: COMPLETED
Conditions: Atheroscleroses, Coronary
Interventions: OTHER: 68Ga-Dotatate PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Parent-Led Interventions in Reducing Infant Hypersensitivity to Pain
Status: UNKNOWN
Conditions: Pain
Interventions: BEHAVIORAL: Educational video - Active|BEHAVIORAL: Educational Video - Sham|DRUG: Sucrose Placebo (water)|DRUG: Sucrose|DRUG: Lidocaine Placebo|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Using Continuous Positive Airway Pressure to Reduce the Incidence of Acute Kidney Injury in Hospitalized Patients With Chronic Kidney Disease
Status: WITHDRAWN
Conditions: Chronic Kidney Disease|Obstructive Sleep Apnea
Interventions: DEVICE: CPAP/autopap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Panitumumab in Combination With Radiotherapy in Patients With Locally Advanced RAS Wildtype Rectal Cancer (Clinical Stages II and III)
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: DRUG: Panitumumab|RADIATION: Radiation of the pelvis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of SIM0237 in Adult Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Locally Advanced Unresectable or Metastatic Solid Tumor
Interventions: DRUG: SIM0237
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RNA Extraction and Amplification From Biopsy Specimens in Subjects With Metastatic Renal Cell Carcinoma (AGS-NTS-017)
Status: TERMINATED
Conditions: Metastatic Renal Cell Carcinoma|Genitourinary Cancer (Bladder, Prostate or Testicular)
Interventions: DEVICE: RNA extraction and amplification from biopsy specimens
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Bioequivalence Study of Two Formulations of Pramipexole Tablets 0.25 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pramipexole Dexa Medica|DRUG: Pramipexole Boehringer Ingelheim Pharma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: DreaMed Advisor Pro System in Subjects With Type 1 Diabetes Treated With MDI Therapy
Status: COMPLETED
Conditions: Insulin-dependent Diabetes Mellitus|Diabetes Mellitus, Type 1
Interventions: DEVICE: Advisor Pro
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alisertib and Gemcitabine Hydrochloride in Treating Patients With Solid Tumors or Pancreatic Cancer
Status: COMPLETED
Conditions: Acinar Cell Adenocarcinoma of the Pancreas|Duct Cell Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage III Pancreatic Cancer|Stage IV Pancreatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: alisertib|DRUG: gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating The Combination Of Neratinib And Capecitabine In Solid Tumors And Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Neratinib|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Type 1 Gaucher Patients to Evaluate the Pharmacokinetics, Safety and Pharmacodynamics of AT2101
Status: TERMINATED
Conditions: Type 1 Gaucher Disease
Interventions: DRUG: AT2101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Venous Access for Pacemaker and Defibrillator Implants
Status: RECRUITING
Conditions: Cardiac Arrhythmia|Heart Failure|AV Block
Interventions: PROCEDURE: Ultrasound guided venous access
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Daily Stress Among Sexual and Gender Minorities
Status: UNKNOWN
Conditions: Social Discrimination|Sexual and Gender Minorities|Mindfulness
Interventions: BEHAVIORAL: Introduction Only|BEHAVIORAL: Purpose Only|BEHAVIORAL: Connection Only|BEHAVIORAL: Connection and Purpose|BEHAVIORAL: Awareness Only|BEHAVIORAL: Awareness and Purpose|BEHAVIORAL: Awareness, Purpose, and Connection|BEHAVIORAL: Awareness and Connection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of a Baby App for Enhancing Infant Mental Well-being (RCT)
Status: NOT_YET_RECRUITING
Conditions: Child Development
Interventions: DEVICE: Smartphone app "Happy Baby HK"|DEVICE: Family Health Service parenting booklet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Open Radical Prostatectomy and Erector Spinae Plane Block
Status: COMPLETED
Conditions: Prostate Cancer|Anesthesia, Local|Pain, Postoperative
Interventions: PROCEDURE: Single-injection ultrasound-guided bilateral erector spinae plane (ESP) block-Sham|PROCEDURE: Single-injection ultrasound-guided bilateral erector spinae plane block-Lidocaine/Bupivacaine|OTHER: Pain follow-up and monitorization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Open Label Study, Assessing the Effect of Diltiazem or Ketoconazole on the Pharmacokinetics of AZD9742 in Healthy Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: AZD9742|DRUG: Diltiazem|DRUG: ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Design and Validation of a New Assessment Tool for Lichen Planopilaris
Status: UNKNOWN
Conditions: Lichen Planopilaris of Scalp|Lichen Plano-Pilaris|Lichen Planopilaris|Frontal Fibrosing Alopecia
Interventions: DIAGNOSTIC_TEST: Boston Grade of Activity in Lichen Planopilaris
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Preoperative Diclofenac Potassium- Acetaminophen Combination on Anesthetic Success in Patients With Symptomatic Irreversible Pulpitis: a Randomized Controlled Trial
Status: UNKNOWN
Conditions: Symptomatic Irreversible Pulpitis
Interventions: DRUG: Diclofenac potassium- acetaminophen combination|DRUG: Diclofenac potassium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Maggot Therapy in Diabetic Foot Ulcers
Status: COMPLETED
Conditions: DIABETIC FOOT ULCERS
Interventions: OTHER: procedure:maggot therapy|OTHER: conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation Of Efficacy Of Liquid Platelet Rich Fibrin In Temporomandibular Joint Disorders
Status: UNKNOWN
Conditions: Temporomandibular Joint Disorders
Interventions: PROCEDURE: Arthrocentesis|PROCEDURE: injectable platelet rich fibrin injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ALT-801 in Patients With Bacillus Calmette-Guerin (BCG) Failure Non-Muscle Invasive Bladder Cancer
Status: TERMINATED
Conditions: Non-muscle Invasive Bladder Cancer
Interventions: BIOLOGICAL: ALT-801|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of a Flowable Bulk Fill Composite Versus a Highly Viscous Glass-ionomer Cement in Primary Molars
Status: RECRUITING
Conditions: Management of Dental Caries of Primary Molars
Interventions: OTHER: Bulk fill flowable composite SDR Dentsply sirona
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Combination of Tivantinib Plus Pemetrexed and Carboplatin
Status: COMPLETED
Conditions: Malignant Pleural Mesothelioma|Nonsquamous Nonsmall Cell Neoplasm of Lung
Interventions: DRUG: Tivantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Rivaroxaban for Early Discharge of Low Risk Pulmonary Embolism From the Emergency Department
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: DRUG: Rivaroxaban|DRUG: Standard-of-care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blind Intubation Through The Self-Pressurised Disposable Air-Q Laryngeal Intubation Mask: An International Multicentre Trial
Status: COMPLETED
Conditions: Elective Surgery Requiring Tracheal Intubation Using an Oral Tracheal Tube
Interventions: DEVICE: Air-Q Intubation Laryngeal Mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Fluid Therapy for the Treatment of Emergency Department Patients With Migraine Headache
Status: COMPLETED
Conditions: Migraine Headache
Interventions: OTHER: Normal saline (1000 mL)|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Progressive Eccentric VS Bodyweight Exercises on Agility, Power and Functional Performance in Hamstring Strain.
Status: RECRUITING
Conditions: Exercise Movement Techniques|Exercise Therapy|Hamstring Injury
Interventions: OTHER: Progressive eccentric exercises|OTHER: Bodyweight exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Behavior Therapy for Irritability in Autism
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Irritability|Disruptive Behavior|Anger|Aggression|Asperger Syndrome|Pervasive Developmental Disorder
Interventions: BEHAVIORAL: Behavioral Therapy for Irritability in Autism|BEHAVIORAL: Psychoeducation and Supportive Therapy (PST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of CTL019 in Adult ALL Patients
Status: WITHDRAWN
Conditions: B-cell Acute Lymphoblastic Leukemia|Relapsed B-cell Acute Lymphoblastic Leukemia|Refractory B-cell Acute Lymphoblastic Leukemia
Interventions: DRUG: CTL019
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: High-Dose Steroid for Hip Arthroplasty Patients Expected to Have Postoperative Pain
Status: COMPLETED
Conditions: Postoperative Pain|Postoperative Nausea and Vomiting|Hip Osteoarthritis|Perioperative/Postoperative Complications|Surgery|Opioid Use|Catastrophizing Pain|Chronic Pain
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study To Assess CAT-2003 in Patients With Hyperlipidemia
Status: COMPLETED
Conditions: Dyslipidemia|Hypercholesterolemia|Hypertriglyceridemia
Interventions: DRUG: CAT-2003|DRUG: Placebo|DRUG: Statin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Point of Care, Real-Time Urine Metabolomics Test to Diagnose Colorectal Cancers and Polyps in Low-and Middle-Income Countries
Status: SUSPENDED
Conditions: Colorectal Cancer Screening
Interventions: DIAGNOSTIC_TEST: Urine PolypDx machine Versus Colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Prediction of Fluid Responsiveness From Passive Leg Raising Induced Changes in Perfusion Index and Pleth Variability Index
Status: COMPLETED
Conditions: Fluid Responsiveness
Interventions: DIAGNOSTIC_TEST: Passive Leg Raising Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rosuvastatin in the Long-term Treatment of Hypercholesterolaemic Subjects With Coronary Heart Disease
Status: COMPLETED
Conditions: Hypercholesteremia
Interventions: DRUG: Rosuvastatin|DRUG: HMG CoA inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antiarrhythmics or Ablation for Ventricular Tachycardia 2
Status: COMPLETED
Conditions: Ventricular Tachycardia (VT)
Interventions: DRUG: Antiarrythmic Drug Therapy|PROCEDURE: Catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevena™ Incisional Negative Pressure Wound Therapy in Re-operative Colorectal Surgery
Status: COMPLETED
Conditions: Surgical Site Infection
Interventions: DEVICE: Prevena wound management system|OTHER: Standard wound dressings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ganetespib With Platinum, in Patients With Malignant Pleural Mesothelioma
Status: COMPLETED
Conditions: Lung Cancer - Malignant Pleural Mesothelioma
Interventions: DRUG: Ganetespib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploring Patient Treatment Preferences for Chronic Pelvic Pain: A Mixed Methods Study
Status: NOT_YET_RECRUITING
Conditions: Chronic Pelvic Pain
Interventions: BEHAVIORAL: My Pelvic Plan website
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Bioavailability, and Food-effects of EA1080 in Healthy Caucasian and Japanese Male Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: EA1080|DRUG: EA1080|DRUG: EA1080|DRUG: EA1080|DRUG: EA1080-matching placebo|DRUG: EA1080|DRUG: EA1080
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of Baricitinib In Treatment of Delayed-Type Hypersensitivity Versus Irritant Skin Reactions in Healthy Adult Male Subjects
Status: COMPLETED
Conditions: Allergic Contact Dermatitis
Interventions: DRUG: Baricitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Single Incision -Vs- Multiple Incision Gastric Band Surgery
Status: COMPLETED
Conditions: Surgery|Post-operative Pain|Post-operative Recovery
Interventions: PROCEDURE: Single Incision Gastric Band Insertion|PROCEDURE: Multiple Incision Gastric Band Insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Human Papillomavirus (HPV) Vaccination on Burden of Disease in Patients With Actinic Keratosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Actinic Keratoses|Basal Cell Carcinoma|Squamous Cell Carcinoma
Interventions: BIOLOGICAL: HPV Vaccine|BIOLOGICAL: PLACEBO vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of TAS3731 in Healthy Adults
Status: COMPLETED
Conditions: Healthy Adult Males
Interventions: DRUG: TAS3731 Dose1|DRUG: TAS3731 Dose2|DRUG: TAS3731 Dose3|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Galactooligosaccharide, Immune Strength, and Digestive Health
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Sucrose|DIETARY_SUPPLEMENT: Galactooligosaccharide|DIETARY_SUPPLEMENT: Galactooligosaccharide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: MK0431 (Sitagliptin) Pioglitazone Add-on Study for Patients With Type 2 Diabetes Mellitus (0431-055)(COMPLETED)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: sitagliptin phosphate|DRUG: Comparator: sitagliptin phosphate (MK0431)|DRUG: Comparator: pioglitazone|DRUG: Comparator: placebo (unspecified)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Steady-State Pharmacokinetic Comparison Study of TNX-102 SL 5.6 mg Versus AMRIX® 30 mg ER Capsules
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: TNX-102 SL 5.6 mg|DRUG: Amrix 30 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of the Effects of Motivational Enhancement Therapy on Alcohol Use in Chronic Hepatitis C Patients
Status: COMPLETED
Conditions: Alcohol Dependence|Chronic Hepatitis C
Interventions: BEHAVIORAL: Motivational Enhancement Therapy (MET)|BEHAVIORAL: Health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Motor Learning for the Lumbar Spine Using Sensor-based Postural Feedback: a Randomized Controlled Trial
Status: UNKNOWN
Conditions: Chronic Non-specific Low Back Pain
Interventions: OTHER: Sensor-based postural feedback|OTHER: Mirror feedback|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A New Prognostic Stratification-based Safety and Efficacy Study of Ruxolitinib in Myelofibrosis
Status: UNKNOWN
Conditions: Myelofibrosis
Interventions: DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing Entacavir and Tenofovir in Patients With HBV Decompensated Cirrhosis
Status: UNKNOWN
Conditions: Cirrhosis Due to Hepatitis B
Interventions: DRUG: Entacavir|DRUG: Tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Evaluate a Method for Plaque When Comparing Stannous Fluoride Toothpaste to a Regular Dentifrice
Status: COMPLETED
Conditions: Plaque|Gingivitis
Interventions: DRUG: stannous fluoride toothpaste|DRUG: cavity protection toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Letrozole and Lapatinib Followed by Everolimus in Women With Advanced Breast Cancer
Status: TERMINATED
Conditions: Breast Neoplasms|Endocrine Breast Diseases|Neoplasm Metastasis
Interventions: DRUG: letrozole|DRUG: lapatinib|DRUG: everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Superiority of Glimepiride Over Sitagliptin in Naive Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: GLIMEPIRIDE (HOE490)|DRUG: SITAGLIPTIN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Culotte Versus DK-CRUSH Technique in Non-left Main Coronary Bifurcation Lesions
Status: UNKNOWN
Conditions: Coronary Stenosis|Stent Stenosis
Interventions: PROCEDURE: Stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy of Platelet Rich Plasma as Anew Modality for Treatment of Atrophic Rhinitis
Status: UNKNOWN
Conditions: Atrophic Rhinitis
Interventions: PROCEDURE: nasal submucosal injection of platelet rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Olmesartan Medoxomil and Diabetic Nephropathy
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Diabetic Nephropathy|Proteinuria|Renal Disease
Interventions: DRUG: Olmesartan medoxomil|DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Asymptomatic Toxocariasis With Albendazole in Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Toxocariasis
Interventions: DRUG: Albendazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Clinical Impact of a Laparoscopic Radical Prostatectomy Simulator
Status: SUSPENDED
Conditions: Prostatic Neoplasms|Cancer of Prostate|Prostate Cancer|Prostate Neoplasms
Interventions: PROCEDURE: Laparoscopic Radical Prostatectomy (without a simulator)|PROCEDURE: Laparoscopic Radical Prostatectomy (with a simulator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Chair Rise and Step Ups on Cardiopulmonary Parameters Among Preserved Ejection Heart Failure Patients
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: Progressive lower limb activities (Chair rise and Step ups)|OTHER: Standard aerobic exercise i.e. low intensity walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Exploring Feasibility of Densification and Optimal Sequencing of Postoperative Adjuvant Fluorouracil, Epirubicin Plus Cyclophosphamide (FEC) and Docetaxel Chemotherapy in Patients With High Risk Primary Operable Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: dose dense with neulasta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Growth of Infants Fed a New Term Infant Formula
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Infant formula (CF)|DIETARY_SUPPLEMENT: Infant Formula (EF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Total Therapy for Infants With Acute Lymphoblastic Leukemia (ALL) I
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: ITMHA|DRUG: Dexamethasone|DRUG: Mitoxantrone|DRUG: Pegaspargase|DRUG: Asparaginase Erwinia Chrysanthemi|DRUG: Bortezomib|DRUG: Vorinostat|DRUG: Cyclophosphamide|DRUG: Mercaptopurine|DRUG: Methotrexate|DRUG: Leucovorin Calcium|DRUG: Cytarabine|DRUG: Etoposide|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b/2, Dose-Escalation Study of Elotuzumab (Humanized Anti-CS1 Monoclonal IgG1 Antibody) in Relapsed Multiple Myeloma
Status: COMPLETED
Conditions: Hematologic Cancer
Interventions: BIOLOGICAL: elotuzumab|DRUG: lenalidomide|DRUG: dexamethasone oral|DRUG: dexamethasone injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of [18F]MNI-815 as a Potential PET Radioligand for Imaging Tau Protein in the Brain of Patients With Tauopathies
Status: COMPLETED
Conditions: Alzheimer's Disease (AD)|Progressive Supranuclear Palsy (PSP)|Cortical Basal Syndrome (CBS)|Frontal Temporal Dementia (FTD)
Interventions: DRUG: [18F]MNI-815 (MNI-815)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: The Clinical Utility of Resistance Training for Improving Cardiovascular Disease Risk in Post-Menopausal Women
Status: COMPLETED
Conditions: Cardiovascular Risk Factor|Menopause Related Conditions|Neuromuscular Function|Aerobic Capacity|Inflammation
Interventions: BEHAVIORAL: Resistance Exercise|BEHAVIORAL: Aerobic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of the Combination of Raltitrexed for Injection and Nab-Paclitaxel in Advanced Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer|Chemotherapy Effect
Interventions: DRUG: raltitrexed for injection|DRUG: nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topo-guided LASIK and Photorefractive Keratectomy vs Wavefront LASIK and Photorefractive Keratectomy
Status: TERMINATED
Conditions: Surgery|Myopia
Interventions: DEVICE: Wavefront optimized LASIK|DEVICE: Wavefront optimized Photorefractive Keratectomy|DEVICE: Topography-guided LASIK|DEVICE: Topography-guided Photorefractive Keratectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality- Working Memory Retraining
Status: COMPLETED
Conditions: Alcohol Use Disorder|Mild Traumatic Brain Injury
Interventions: BEHAVIORAL: VR-WMR-Only|BEHAVIORAL: Exercise-only|BEHAVIORAL: Active VR-WMR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Vasoconstriction Trial With LEO 90100 Aerosol Foam
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: LEO 90100 aerosol foam|DRUG: Dermoval®/Dermovate®|DRUG: Diprosone|DRUG: Elocon|DRUG: Locoid|OTHER: LEO 90100 foam vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT