pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Perioperative Magnesium Sulphate as a Cerebral Protector in Neurosurgical Patients
Status: COMPLETED
Conditions: Seizures (Incl Subtypes)|Brain Tumor
Interventions: DRUG: Magnesium Sulfate|OTHER: Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Comparison of Hyaluronic Acid and Estradiol Treatment in Vulvovaginal Atrophy.
Status: COMPLETED
Conditions: Vulvovaginal Atrophy
Interventions: DRUG: Hyaluronic acid vaginal gel|DRUG: Estrogen vaginal use form
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aesthetic Efficacy of Resin Infiltration Using Different Conditioning Methods: 24-Month Results
Status: COMPLETED
Conditions: White Spot Lesion
Interventions: OTHER: 15% HCl gel|OTHER: H3PO4 gel|OTHER: Er:YAG laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Dupilumab in Patients With Severe Steroid Dependent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Dupilumab|DRUG: Placebo|DRUG: Oral corticosteroid therapy (prednisone/prednisolone)|DRUG: Inhaled corticosteroid (ICS) therapy|DRUG: Albuterol/Salbutamol|DRUG: Levalbuterol/Levosalbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Minimizing Lung Injury During Laparoscopy in Steep Trendelenburg Position
Status: COMPLETED
Conditions: Atelectasis
Interventions: PROCEDURE: Decremental PEEP|DIAGNOSTIC_TEST: Lung ultrasound score|DIAGNOSTIC_TEST: Blood gas analysis|DIAGNOSTIC_TEST: Registration of respiratory mechanics|DIAGNOSTIC_TEST: Evaluation of dead space
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Comparison of Standard Antiviral Therapy With and Without 12 Weeks of Betaine in Genotype 1 Naive Patients
Status: WITHDRAWN
Conditions: Chronic Hepatitis C
Interventions: DRUG: Peginterferon alpha-2a and ribavirin|DRUG: Peginterferon alpha-2a , ribavirin and betaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and PK of Multiple-ascending Doses of Emodepside
Status: COMPLETED
Conditions: Filariasis
Interventions: DRUG: LSF emodepside (BAY 44-4400) or matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Restricted Intravenous Fluid Regime Effects on Immunological Indicators of Elderly Patients Operated for Abdominal Cancer
Status: COMPLETED
Conditions: Surgery|Perioperative Care|Immunization|Abdominal Neoplasms
Interventions: BEHAVIORAL: perioperative fluid management|BEHAVIORAL: perioperative fluid treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Herbal Immunomodulators in the Treatment of Chronic Periodontitis
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: DRUG: herbal immunomodulator|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DEPOSITION - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery
Status: TERMINATED
Conditions: Bleeding|Surgical Blood Loss|Seizures
Interventions: DRUG: Tranexamic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Stereotactic Body Radiation Therapy (SBRT) as a Boost After Definitive Concurrent Chemoradiation (ChemoRT) for Non-Small Cell Lung Cancer (NSCLC) GCC 0516
Status: WITHDRAWN
Conditions: Non-Small Cell Lung Cancer (NSCLC)
Interventions: RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of e- Ab Sensor - Based Real-time Diagnosis of Serum Procalcitonin Level
Status: COMPLETED
Conditions: Sepsis
Interventions: DEVICE: Electrosensing Antibody Probe System (e- Ab sensing)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Medacta International GMK Sphere Cementless Post-Marketing Surveillance Study
Status: RECRUITING
Conditions: Arthritis|Traumatic Arthritis|Rheumatoid Arthritis|Poly-arthritis|Avascular Necrosis
Interventions: DEVICE: GMK Sphere cementless Knee Replacement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Scapular Stabilization Exercises in Individuals With Adolescent Idiopathic Scoliosis
Status: RECRUITING
Conditions: Adolescent Idiopathic Scoliosis
Interventions: OTHER: Scapular Stabilization Exercises|OTHER: Schroth Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of OMEGA Gemini Capsule, Model Gemini IV With an Approved Monofocal or Toric IOL
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Gemini IV|DEVICE: Control Eye
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Lacto-ovo-vegetarian Diet Riched in Omega-3 Fatty Acids in Menopausal Women
Status: UNKNOWN
Conditions: Menopause|Metabolic Syndrome|Hepatic Steatosis
Interventions: OTHER: Diet rich in omega-3 fatty acids|OTHER: Diet with extra virgin olive oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: TapTalkTest Project:Development of a Non-invasive Screening Test to Detect Risk of Alzheimer's Disease Pathology
Status: ENROLLING_BY_INVITATION
Conditions: Alzheimer Disease|Dementia|Movement Abnormalities|Speech Disorders
Interventions: DIAGNOSTIC_TEST: Tap Talk online program
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Embolization of Pelvic Veins in Treatment of Pelvic Congestion Syndrome
Status: WITHDRAWN
Conditions: Pelvic Congestive Syndrome
Interventions: DEVICE: coil|DEVICE: hystoacryl glue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
Status: RECRUITING
Conditions: Geographic Atrophy
Interventions: BIOLOGICAL: OpRegen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Develop a Reliable Nomogram That Incorporates Clinical and Genetic Information
Status: COMPLETED
Conditions: Pulmonary Embolism|Deep Vein Thrombosis|Atrial Fibrillation
Interventions: DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Imatinib With Reinduction Chemotherapy Using Mitoxantrone, Etoposide and Cytarabine in Patients With Relapsed/Refractory C-kit Positive (AML) Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Imatinib (Gleevec)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Tranexamic Acid in Reduction Mammoplasty
Status: COMPLETED
Conditions: Hematoma Postoperative|Venous Thromboembolism
Interventions: DRUG: Tranexamic acid|OTHER: Placebo (topical saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of Nipocalimab for Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Status: RECRUITING
Conditions: Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Interventions: DRUG: Nipocalimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of PepCan to Two Therapy Arms for Treating Cervical High-Grade Squamous Intraepithelial Lesions
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia
Interventions: BIOLOGICAL: PepCan|BIOLOGICAL: Candin®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Grade IV GBM Patients
Status: UNKNOWN
Conditions: GBM
Interventions: DRUG: Chlorogenic acid for Injection|DRUG: Lomustine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Actos Lipitor Pegasys & Ribavirin in CHC GT 1 Patients Who Relapsed or Nonresponded to Peg/Riba
Status: COMPLETED
Conditions: Hepatitis c
Interventions: DRUG: pioglitazone (Actos)|DRUG: atorvastatin (Lipitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cost-consequence Analysis of Parenchymal Stapling Device Versus Hand-sewing for Pulmonary Lobectomy in Lung Disease
Status: COMPLETED
Conditions: Malignant Neoplasm of Bronchus or Lung, Unspecified
Interventions: DEVICE: stapling device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of AT-527 in Subjects With Normal and Impaired Renal Function
Status: COMPLETED
Conditions: Healthy Volunteer|Renal Impairment
Interventions: DRUG: AT-527|DRUG: AT-527|DRUG: AT-527 and Probenecid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open, Randomized, Two Way Crossover 40mg, Orally and Intravenously
Status: COMPLETED
Conditions: GERD
Interventions: DRUG: Esomeprazole|DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Continuous ESP Versus TEA After Thoracotomy
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: PROCEDURE: Erector spinae plane block group|PROCEDURE: Thoracic epidural analgesia group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blood Flow Reserve: Effects After Training With Heavy Inspiratory Exercises
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: High-intensity IMST|DEVICE: Low-intensity IMST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eltrombopag for Thrombocytopenia in Patients With Relapsed Multiple Myeloma
Status: TERMINATED
Conditions: Thrombocytopenia|Multiple Myeloma
Interventions: DRUG: Eltrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UltraSound for Accurate Decisions in Chest PhysioTherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Critical Illness|Respiratory Disease
Interventions: DIAGNOSTIC_TEST: Lung and diaphragm ultrasound|DIAGNOSTIC_TEST: Lung and diaphragm ultrasound in MV patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Vasopressors on Spinal Anaesthesia Induced Hypotension
Status: COMPLETED
Conditions: Spinal Anesthesia
Interventions: DRUG: Epinephrine|DRUG: Norepinephrine|DRUG: Phenylephrine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Tendon Vibrations Effect on Upper Limb Motor Recovery After Recent Stroke
Status: UNKNOWN
Conditions: Stroke/Brain Attack|Upper Extremity Paresis
Interventions: OTHER: Upper limb repeated multi-site tendon vibrations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Integrating Electronic Patient Reported Biometric Measures (ePReBMs) From Wearable Devices in Respiratory Diseases
Status: COMPLETED
Conditions: Progressive Fibrosing Interstitial Lung Disease|Lung Transplant|Cystic Fibrosis|Bronchiectasis|Pulmonary Tuberculosis
Interventions: DEVICE: ADAMM- RSM Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Jarro-Dophilus EPS® Probiotic Formulations
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Jarro-Dophilus EPS® (5 billion CFU/capsule)|DIETARY_SUPPLEMENT: Jarro-Dophilus EPS® High Potency (25 billion CFU/capsule)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate 3 Different Dosing Regimens of Mipomersen Administered Via Subcutaneous Injections to Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: mipomersen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Intensity Laser Therapy (Classes IV) and Ibuprofen Gel Phonophoresis for Treating Knee Osteoarthritis
Status: UNKNOWN
Conditions: Osteo Arthritis Knee
Interventions: OTHER: High Intensity LASER Therapy|OTHER: Ibuprofen gel phonophoresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Fentanyl Citrate in Children
Status: COMPLETED
Conditions: Children
Interventions: DRUG: midazolam and fentanyl citrate infusion|DRUG: midazolam and normal saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy, Immunogenicity and Safety Study of GSK Biologicals' Candidate Malaria Vaccine Evaluating Different Dose Schedules in a Sporozoite Challenge Model in Healthy Malaria-naïve Adults
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: RTS,S/AS01E|BIOLOGICAL: RTS,S/AS01B|PROCEDURE: Sporozoite-infected mosquitoes challenge.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Mulligan Mobilization With and Without Sling Exercises in Non-specific Neck Pain
Status: RECRUITING
Conditions: Neck Pain
Interventions: OTHER: Mulligan Mobilization and Sling Exercises|OTHER: Mulligan Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Tolerability, and Effect of AL208 on Mild Cognitive Impairment Following Coronary Artery Bypass Graft Surgery
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: DRUG: AL-208|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Tilburg Vasospasm Study
Status: TERMINATED
Conditions: Brain Ischemia|Intracranial Vasospasm
Interventions: PROCEDURE: external lumbar drainage (ELD) of cerebrospinal fluid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ulinastatin Improves Postoperative Oxygenation After Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Cardiopulmonary Bypass|Cardiac Surgery
Interventions: DRUG: ulinastatin|DRUG: control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Revofit™ System Evaluation on Residual Limb Pain in Amputee Patients
Status: TERMINATED
Conditions: Amputation|Adult Disease
Interventions: OTHER: Socket without Revofit system|OTHER: Socket with Revofit system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise and Breast Cancer Related Lymphedema: Influence of Muscle Group and Sequence on Volume Change in Swollen and Normal Arms
Status: UNKNOWN
Conditions: Breast Cancer|Lymphedema
Interventions: OTHER: Exercise|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Uridine Supplementation on Metabolic Side Effects of Stavudine and Zidovudine
Status: COMPLETED
Conditions: HIV Infections|Insulin Resistance|Hyperlactatemia
Interventions: DRUG: NucleomaxX (contains uridine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Thalidomide in Refractory/Relapsed Diffuse Large B-Cell Lymphoma and Hodgkin's Disease
Status: TERMINATED
Conditions: B-Cell Lymphoma|Hodgkin's Disease
Interventions: DRUG: Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Observe Safety And Blood Concentrations Of PF-04995274 During And Following the Administration of Multiple Doses Of PF-04995274 In Healthy Adult And Healthy Elderly Volunteers.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 0.1 mg PF-04995274|DRUG: 1 mg PF-04995274|DRUG: 10 mg PF-04995274|DRUG: 15 mg PF-04995274|DRUG: 1.0 mg PF-04995274|DRUG: 15 mg PF-04995274
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Study of ARO-ENaC in Healthy Volunteers and in Patients With Cystic Fibrosis
Status: TERMINATED
Conditions: Cystic Fibrosis, Pulmonary
Interventions: DRUG: ARO-ENaC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of APR-246 in Patients With Refractory Hematologic Cancer or Prostate Cancer
Status: COMPLETED
Conditions: Hematologic Neoplasms|Prostatic Neoplasms
Interventions: DRUG: APR-246
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemirolast in Allergen Challenge (PEMAG)
Status: TERMINATED
Conditions: Allergic Asthma
Interventions: DRUG: Pemirolast|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized-Controlled Trial to Examine the Effects of a Daily Probiotic Supplement on Common Symptoms of Menopause
Status: ACTIVE_NOT_RECRUITING
Conditions: Menopause
Interventions: DIETARY_SUPPLEMENT: Provitalize Natural Menopause Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Pilot Study of Functional Optical Coherence Tomography for Ocular Imaging
Status: COMPLETED
Conditions: Glaucoma|Diabetic Retinopathy|Age-Related Macular Degeneration|Central Retinal Vein Occlusion|Branch Retinal Vein Occlusion
Interventions: DEVICE: Optical Coherence Tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Implementing Continuous Glucose Monitoring in Primary Care for Patients With Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2|Continuous Glucose Monitoring
Interventions: OTHER: Virtual CGM initiation service|OTHER: Online educational module on CGM|OTHER: Practice facilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Same Day Dosing of Pegfilgrastim in Breast Cancer Patients Undergoing Chemotherapy (TAC)
Status: COMPLETED
Conditions: Breast Cancer|Fever|Neutropenia
Interventions: DRUG: pegfilgrastim|DRUG: docetaxel|DRUG: doxorubicin|DRUG: cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Frailty Syndrome in Daily Practice of Interventional Cardiology Ward
Status: RECRUITING
Conditions: Frail Elderly Syndrome|Coronary Heart Disease|Acute Coronary Syndrome|Coronary Artery Bypass Grafting|Percutaneous Transluminal Coronary Angioplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of a Specific Transdermal Cannabidiol Product for Chronic Musculoskeletal Joint Pain.
Status: WITHDRAWN
Conditions: Musculoskeletal Joint Pain
Interventions: DRUG: Cannabidiol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Collection of Samples From Pregnant Women for the Evaluation of Preeclampsia (Pre-E) Biomarkers
Status: COMPLETED
Conditions: Preeclampsia|Hypertension|Proteinuria|Thrombocytopenia|Renal Insufficiency|Impaired Liver Function|Pulmonary Edema
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Novel Skin Barrier Protectant for Acute Radiodermatitis
Status: WITHDRAWN
Conditions: Radiodermatitis|Radiation Toxicity|Radiation Dermatitis|Skin Diseases|Head and Neck Cancer
Interventions: DEVICE: Cavilon Advanced Skin Protectant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retina Implant Pilot Trial to Evaluate Safety & Efficacy in Blind Patients Having Degenerated Photo-receptors
Status: COMPLETED
Conditions: Retinitis Pigmentosa
Interventions: DEVICE: Retina implant is surgically placed into subretinal position
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Letermovir Use in Heart Transplant Recipients
Status: ACTIVE_NOT_RECRUITING
Conditions: Cytomegalovirus Disease|Cytomegalovirus Infections|Heart Transplant Infection|Antiviral Toxicity|Neutropenia
Interventions: DRUG: Letermovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cognitive Remediation Therapy for Participants With Late-Life Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Cognitive Remediation|Late Life Schizophrenia|Functional Impairment|Cognitive Deficit
Interventions: OTHER: Cognitive Remediation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Carboplatin and Mirvetuximab Soravtansine in First-Line Treatment of Patients Receiving Neoadjuvant Chemotherapy With Advanced-Stage Ovarian, Fallopian Tube or Primary Peritoneal Cancer
Status: RECRUITING
Conditions: Ovarian Cancer|Fallopian Tube|Primary Peritoneal Cancer
Interventions: DRUG: mirvetuximab soravtansine (MIRV; IMGN853)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Objective to Evaluate the Safety and Effectiveness of LED Light Source System for Endoscopy in Ureteral Radiography
Status: WITHDRAWN
Conditions: Lower Abdominal Surgery|Pelvic Surgery
Interventions: DEVICE: LED light source system for endoscope|DEVICE: Ureteral stent (Cook Ireland Ltd.)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Epirubicin and Paclitaxel, Alone or Together With Capecitabine as First Line Treatment in Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Epirubicin|DRUG: Paclitaxel|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementing Shared Decision Making (SDM) For Individualized CV Prevention (SDM4IP)
Status: ENROLLING_BY_INVITATION
Conditions: Cardiovascular Risk|Cardiovascular Prevention
Interventions: BEHAVIORAL: CV Prevention Choice Tool|BEHAVIORAL: Implementation Facilitation Strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Transcutaneous Auricular Neurostimulation (tAN) for Symptoms of Opioid Withdrawal
Status: COMPLETED
Conditions: Opioid-use Disorder|Opioid Withdrawal
Interventions: DEVICE: transcutaneous auricular neurostimulation (tAN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Capsule Colonoscopy in Crohn's Disease and Its Correlation With Conventional Colonoscopy and Faecal Calprotectin
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DEVICE: PillCam® COLON 2 Capsule Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effectiveness of Dry Needling Treatment in Patients Diagnosed With Dorsal Myofascial Pain Syndrome.
Status: NOT_YET_RECRUITING
Conditions: Myofascial Trigger Point Pain
Interventions: OTHER: Real dry needling|OTHER: Sham dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Endobiliary Radiofrequency Ablation by Using a Novel RF Catheter (ELRA®) on Maintaining the Patency of Endobiliary Metal Drainage in Patients With Malignant Biliary Strictures : A Double-arm Comparable Study
Status: UNKNOWN
Conditions: Cholangiocarcinoma, Gallbladder Cancer, Pancreatic Cancer
Interventions: DEVICE: Radiofrequency ablation with stenting|DEVICE: stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Concurrent Radiotherapy With Envafolimab and Capecitabine in LAPC
Status: RECRUITING
Conditions: Pancreatic Cancer|Radiotherapy|Envafolimab|Capecitabine
Interventions: RADIATION: concurrent radiotherapy with envafolimab and capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Shockwave Therapy on Crouched Gait Due to Hamstring Flexibility in Cerebral Palsy Children
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: Shock wave therapy, stretching and orthosis|OTHER: Stretching, strengthening and orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Glucose Degradation Products (GDP) on Endothelial Dysfunction
Status: COMPLETED
Conditions: Kidney Failure, Chronic|Disorders Associated With Peritoneal Dialysis
Interventions: DRUG: Balance, Fresenius Medical Care, Germany
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of the RAPID AFib Decision Aid for Stroke Prevention in Atrial Fibrillation
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation
Interventions: BEHAVIORAL: Electronic patient decision aid|OTHER: Information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Intranasal Administration of a Single Dose of Oxytocin Using a Novel Device in Healthy Adults
Status: COMPLETED
Conditions: Healthy Male Adults
Interventions: DRUG: 8IU intranasal oxytocin|DRUG: 24 IU intranasal oxytocin|DRUG: 1 IU intravenous oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacokinetics of Megace F and Megace OS Under Fasting and Fed Conditions in Healthy Male Volunteers
Status: COMPLETED
Conditions: Cachexia|Anorexia
Interventions: DRUG: Megace F|DRUG: Megace OS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Non-invasive Ventilation and High-flow Nasal Oxygen Therapy for Preventing Delayed Respiratory Failure in Hypoxemic Blunt Chest Trauma Patients.
Status: COMPLETED
Conditions: Chest Injuries|Respiratory Failure
Interventions: COMBINATION_PRODUCT: Preventive strategy|COMBINATION_PRODUCT: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Baclofen on Presynaptic Inhibition in Humans
Status: WITHDRAWN
Conditions: Spasticity, Muscle|Spinal Cord Injuries
Interventions: DRUG: Baclofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Breathing Protocol in Breath-hold Divers
Status: UNKNOWN
Conditions: Exercise Training|Apnea|Breathholding|Breathing Exercises
Interventions: OTHER: hook breathing removing nose-clip|OTHER: usual breathing (UB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Mild Cognitive Impairment Patients With Aloe and Crocus - BALSAM
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: DIETARY_SUPPLEMENT: Dietary Supplement:Aloe Vera with Crocus (saffron)|DIETARY_SUPPLEMENT: Dietary Supplement:Aloe Vera (simple)|DIETARY_SUPPLEMENT: Dietary Supplement:Mediterranean Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Glycemic and Insulinemic Impact of a Test Granola 3 Versus a Control Granola
Status: COMPLETED
Conditions: Glycemic Response|Insulinemic Response|Subjectvie Hunger
Interventions: OTHER: Test Granola|OTHER: Control Granola
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cardiac Sympathetic Denervation for Prevention of Ventricular Tachyarrhythmias
Status: RECRUITING
Conditions: Sudden Cardiac Death|Ventricular Tachycardia|Ventricular Fibrillation|Cardiomyopathy
Interventions: PROCEDURE: Cardiac Sympathetic Denervation (CSD)|DRUG: Routine Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Efficacy and Safety of Intra-wound Vancomycin Powder in High Risk Patients
Status: RECRUITING
Conditions: Spinal Deformity|Trauma|Spinal Tumor|Surgical Site Infection
Interventions: DRUG: Vancomycin powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cohort Study Evaluating the Clinical Effectiveness, Safety and Immunogenicity to the Pandemic Influenza Vaccination
Status: COMPLETED
Conditions: Cystic Fibrosis With Gastrointestinal Manifestation
Interventions: BIOLOGICAL: influenza vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prevalence of Thrombophilic Gene Polymorphism (MTHFR C677T) in COVID-19patients
Status: COMPLETED
Conditions: COVID 19 Associated Coagulopathy
Interventions: DIAGNOSTIC_TEST: RT- PCR of 2 ml EDTA blood sample to determine MTHFR C677T genotypes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PERS Genetic Model Assistant Decision-making System of Neoadjuvant Chemotherapy for Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer Model|Effects of Chemotherapy|Breast Cancer
Interventions: DRUG: NVB|DRUG: EPI|DRUG: DDP|DRUG: CAP|DRUG: GEM|DRUG: H|DRUG: CTX|DRUG: T
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Virtual Reality Supported Core Stabilization Exercises and Basic Body Awareness Therapy Activities in Individuals With Adolescent Idiopathic Scoliosis
Status: NOT_YET_RECRUITING
Conditions: Scoliosis Idiopathic Adolescent|Body Image
Interventions: OTHER: Body Awareness Therapy Exercise|OTHER: Virtual Reality Exercise|OTHER: Core Stability Exercise|OTHER: Home Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Market Research - Acceptability Study for New MCT Fat Products
Status: COMPLETED
Conditions: Ketosis|Epilepsy|Fatty Acid Oxidation Disorder|Malabsorption|Ketogenic Diet|Medium Chain Triglycerides
Interventions: DIETARY_SUPPLEMENT: MCT fats
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Tazarotene 0.045% Lotion for Treating PIE and PIH in Subjects With Acne
Status: COMPLETED
Conditions: Acne Vulgaris|Post Inflammatory Hyperpigmentation|Post Inflammatory Pigmentation Change|Erythema|Skin Scarring
Interventions: DRUG: Tazarotene 0.045% Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Intensity Modulated Total Marrow Irradiation (IM-TMI) in Addition to Fludarabine/Busulfan Conditioning for Allogeneic Transplantation in High Risk AML and Myelodysplastic Syndromes
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: Fludarabine|DRUG: Busulfan|DRUG: ATG|RADIATION: Total Marrow Irradiation|PROCEDURE: Stem Cell Product Infusion|DRUG: Tacrolimus|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypertension in Hemodialysis Patients (Aim 3)
Status: TERMINATED
Conditions: Hemodialysis|Hypertension|Left Ventricular Hypertrophy
Interventions: DRUG: Lisinopril|DRUG: Atenolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Energy Balance and Inflammation in Obese Adults Bariatric Surgery Follow-up
Status: UNKNOWN
Conditions: Obesity|Morbid Obesity|Metabolic Syndrome|Inflammation|Energy Balance
Interventions: PROCEDURE: Roux-en-Y gastric bypass (bariatric surgery)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic, Pharmacodynamic and Tolerability Study of Otamixaban in Patients With Mild, Moderate and Severe Renal Impairment
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: OTAMIXABAN (XRP0673)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of ARRY-371797 in Patients With Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: ARRY-371797, p38 inhibitor; oral|DRUG: Oxycodone hydrochloride (HCl) extended release (ER), opioid agonist; oral|DRUG: Placebo; oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tafenoquine Thorough QTc Study in Healthy Subjects
Status: COMPLETED
Conditions: Malaria, Vivax
Interventions: DRUG: Tafenoquine 300mg|DRUG: Tafenoquine 600mg|DRUG: Tafenoquine 1200mg|DRUG: moxifloxacin|DRUG: Placebo for Tafenoquine|DRUG: Placebo for moxifloxaxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Lidocaine Infusion for Pain Relief in Children Scheduled for Tonsillectomy and Adenoidectomy
Status: COMPLETED
Conditions: Children, Only|Tonsillar Hypertrophy|Adenoid Hypertrophy
Interventions: DRUG: Lidocaine Iv|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Gabapentin for Neuropathic Pain in Fabry Disease
Status: WITHDRAWN
Conditions: Fabry Disease|Neuropathic Pain
Interventions: DRUG: Gabapentin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Valsalva Urethral Profile : a Measure to Assess Stress Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: DIAGNOSTIC_TEST: Maximum urethral closure pressure during Valsalva (v-MUCP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Misoprostol Dose and Timing Before Surgical Abortion at 13 to 16 Weeks' Gestation: a Randomized Trial
Status: COMPLETED
Conditions: Abortion, Induced
Interventions: DRUG: Misoprostol 400 mcg 3 hours prior to procedure|DRUG: Misoprostol 600 mcg 90 minutes prior to procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Bio-Equivalence Study of Budesonide Prolonged-release Tablets 9 Mg In Healthy Human Adult Subjects
Status: COMPLETED
Conditions: Healthy Subjects|Human Volunteers|Healthy Participants|Bioequivalence
Interventions: DRUG: Cortiment|DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intranasal Dexmedetomidine for Deep-sedated Pediatric Dental Patients
Status: COMPLETED
Conditions: Deep Sedation|Dexmedetomidine
Interventions: DRUG: Dexmedetomidine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Artesunate Pessaries (Vaginal Inserts) for Cervical Precancer in Kenya
Status: RECRUITING
Conditions: Cervix Cancer|Cervix Neoplasm|Precancerous Conditions|Cervical Precancer
Interventions: DRUG: Artesunate pessary|PROCEDURE: Colposcopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-FODMAP Diet for Functional Abdominal Pain Disorders in Children.
Status: RECRUITING
Conditions: Functional Abdominal Pain Disorder
Interventions: OTHER: Low-FODMAP diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tricaprilin Liquid Formulation PK Study
Status: TERMINATED
Conditions: Alzheimer Disease
Interventions: DRUG: AC-1202|DRUG: AC-OLE-01|DRUG: AC-OLE-02|DRUG: AC-OLE-03|DRUG: AC-OLE-04|DRUG: AC-OLE-05|DRUG: AC-OLE-06|DRUG: AC-OLE-07|DRUG: AC-OLE-08|DRUG: AC-OLE-09|DRUG: AC-OLE-010|DRUG: AC-OLE-P
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Radiological Biological Genetic and Micro-architectural Bone Determinants of Fractures in Men With Low Bone Mineral Density
Status: COMPLETED
Conditions: Osteoporosis
Interventions: OTHER: Radiology|OTHER: Biological, biochemical and genetic samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Safety And Feasibility of Early DischargE - a Prospective And Randomized Trial of Low-risk Primary Percutaneous Coronary Intervention (PCI) Patients
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: BEHAVIORAL: Early hospital discharge facilitated by close nurse practitioner follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Concurrent Chemoradiotherapy Containing Paclitaxel&Cisplatin With/Without Tarceva in Locally Advanced Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: DRUG: Paclitaxel|DRUG: Cisplatin|DRUG: Tarceva|RADIATION: Radiotherapy|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Possibility to Stop Perdialytic Heparin Therapy in Hemodialysed Patients With HeprAN ™ Membrane and Treated by Long-term Anticoagulation With VKA
Status: UNKNOWN
Conditions: Chronic Hemolysis|VKA|Anticoagulants / Administration & Dosage|Coated Materials|Biocompatible|Heparin / Administration & Dosage|Membranes Artificial|Prospective Studies|Renal Dialysis / Methods|Renal Insufficiency / Therapy
Interventions: DRUG: Decrease per-dialytic heparin therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Radiation Therapy With or Without Panitumumab in Treating Patients Who Have Undergone Surgery for Advanced Hypopharyngeal Cancer, Oropharyngeal Cancer, Laryngeal Cancer, or Oral Cavity Cancer at High Risk of Recurrence
Status: WITHDRAWN
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: panitumumab|DRUG: cisplatin|DRUG: fluorouracil|OTHER: laboratory biomarker analysis|PROCEDURE: adjuvant therapy|PROCEDURE: quality-of-life assessment|RADIATION: 3-dimensional conformal radiation therapy|RADIATION: intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: U/S Guided Rhomboid Intercostal Block Combined With Sub-Serratus Plane Block vs Type 2 Pectoral Nerve Block
Status: COMPLETED
Conditions: Breast Neoplasm Female|Analgesics
Interventions: PROCEDURE: U/S guided Type 2 Pectoral Nerve Block|PROCEDURE: U/S guided RIB combined with the sub-serratus plane block (RISS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Intradermal Lidocaine Via MicronJet600 Microneedle Device
Status: COMPLETED
Conditions: Local Anaesthesia
Interventions: DEVICE: Intravenous cannulation after intradermal injection of lidocaine via MicronJet600 microneedle device (1)|DEVICE: Intravenous cannulation after intradermal injection of saline via MicronJet600 microneedle device|DEVICE: Intravenous cannulation after intradermal injection of lidocaine via MicronJet600 microneedle device (2)|PROCEDURE: Intravenous cannulation after without prior interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atrovent in Exercise Induced Laryngeal Obstruction (EILO)
Status: COMPLETED
Conditions: Exercise Induced Laryngeal Obstruction (EILO)
Interventions: DRUG: Ipratropium bromide spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immuno,Safety of GSK Vaccine 134612 Given at Age of 12-15 Months 15-18 Months Post-priming With GSK Vaccine 792014
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: GSK Biologicals' Meningococcal vaccine GSK134612 (Nimenrix)|BIOLOGICAL: GSK Biologicals' Hib-meningococcal vaccine GSK 792014 (Menhibrix)|BIOLOGICAL: Infanrix®|BIOLOGICAL: ActHIB®|BIOLOGICAL: Pediarix®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Nitrous Oxide for Pain Management of Intrauterine Device (IUD) Insertion
Status: COMPLETED
Conditions: Contraception
Interventions: PROCEDURE: IUD insertion|DRUG: Povidone-Iodine|DRUG: Chlorhexidine|OTHER: Oxygen|OTHER: Nitrous oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Drug-Eluting Vertebral Artery Stenting Treatment for Atherosclerotic Vertebral Arteries Stenosis
Status: RECRUITING
Conditions: Ischemic Stroke|Vertebral Artery Stenosis
Interventions: DEVICE: The drug-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT