pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Tongxinluo Capsule in the Treatment of Cerebral Small Vessel Disease-A Randomized, Double-blind, Placebo-controlled, Multicenter Clinical Study（TOPS-CSVD）
Status: NOT_YET_RECRUITING
Conditions: Cerebral Small Vessel Diseases
Interventions: DRUG: Tongxinluo Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tailored Second Line Treatment by Epidermal Growth Factor Receptor (EGFR) Mutation in Patients With Advanced Lung Adenocarcinoma
Status: UNKNOWN
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: erlotinib (Tarceva)|DRUG: pemetrexed (Alimta)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: LMWH for Treatment of Early Fetal Growth Restriction (HepaGrowth)
Status: ENROLLING_BY_INVITATION
Conditions: Fetal Growth Retardation|Prematurity|Pre-Eclampsia
Interventions: DRUG: subcutaneous Enoxaparin|OTHER: standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute and Chronic Pain After One-stage Hybrid Arrhythmia Ablation Surgery
Status: RECRUITING
Conditions: Arrythmia|Chronic Pain|Acute Pain|Post Operative Pain
Interventions: OTHER: Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of the Defocus Incorporated Spectacle Lenses on Fast Progressing Myope
Status: RECRUITING
Conditions: Myopia
Interventions: OTHER: Variant of Defocus Incorporated Spectacle lens (DG2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gradual vs. Abrupt Cessation Treatment for Smoking
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Reduction Phone Counseling|BEHAVIORAL: Abrupt Phone Counseling|BEHAVIORAL: Minimal Abrupt Phone Counseling|DRUG: Pre-Quit Nicotine Lozenges|DRUG: Post-Quit Nicotine Lozenges
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-Crossover Study of the LMA Protector Versus Ambu AuraGain
Status: COMPLETED
Conditions: Airway Morbidity
Interventions: PROCEDURE: function tests|DEVICE: LMA ProtectorTM|DEVICE: Ambu AuraGainTM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Mouthwash Containing Pomegranate Peel Extract and Chlorhexidine Mouthwash on Bleeding on Brushing
Status: UNKNOWN
Conditions: Gingival Bleeding
Interventions: DRUG: Pomegranates peel extract|DRUG: Chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomechanical Investigation of Symptomatic FAI and Two Groups of Asymptomatic Controls
Status: RECRUITING
Conditions: Femoroacetabular Impingement
Interventions: DIAGNOSTIC_TEST: EOS|DIAGNOSTIC_TEST: 3D motion lab analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Zeolite + Dolomite on Performance and Acidosis
Status: COMPLETED
Conditions: Acidosis|Oxidative Stress|Inflammation
Interventions: DEVICE: zeolite + dolomite|DEVICE: cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mobile Health-based Motivational Interviewing to Promote COVID-19 Vaccination
Status: NOT_YET_RECRUITING
Conditions: Vaccination Hesitancy
Interventions: BEHAVIORAL: Standard MI|BEHAVIORAL: Intensive MI|BEHAVIORAL: MOTIVACC|BEHAVIORAL: Ecological momentary assessment (EMA) messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect Of Digital Smile Design on Quality Of Life In Complete Denture Wearers
Status: NOT_YET_RECRUITING
Conditions: Complete Edentulism
Interventions: PROCEDURE: complete denture, CG|PROCEDURE: complete denture, DG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Keck Medicine of University of Southern California Thrive Study
Status: RECRUITING
Conditions: Burnout
Interventions: BEHAVIORAL: Emotional Wellbeing|BEHAVIORAL: EHR Skills Optimization|BEHAVIORAL: Performance Improvement|BEHAVIORAL: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Explore the Efficacy of JNJ-67953964 in the Treatment of Depression
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: JNJ-67953964|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tourniquet Binding of Cervical on the Blood Volume of Amniotic Fluid in Cesarean Section
Status: NOT_YET_RECRUITING
Conditions: Amniotic Fluid Embolism|Pulmonary Hypertension
Interventions: PROCEDURE: tourniquet binding of cervical
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dimensional Changes of Peri-implant Facial Bone
Status: COMPLETED
Conditions: Jaw, Edentulous, Partially
Interventions: PROCEDURE: implant insertion and abutment connection|DEVICE: osseointegrated implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interactions Between Intravenous (IV) Cocaine and Lofexidine
Status: TERMINATED
Conditions: Cocaine Related Disorders
Interventions: DRUG: Lofexidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Homeopathy as an Adjuvant to Chemotherapy Improves Clinical Outcome in Relapsed Pulmonary Tuberculosis
Status: COMPLETED
Conditions: Pulmonary Tuberculosis
Interventions: DRUG: Anti-Tuberculosis Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Alendronate Sodium Vitamin D3 Tablets on Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DRUG: alendronate sodium vitamin D3 tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: School Readiness Intervention for Preschool Children With Sickle Cell Disease
Status: RECRUITING
Conditions: Sickle Cell Disease
Interventions: DEVICE: The adapted Kids in Transition to School Intervention|DEVICE: Standard school resources
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Very Low Carbohydrate Ketogenic Diet or Mediterranean Diet on Markers of Musculoskeletal Health in Older Adults
Status: RECRUITING
Conditions: Aging|Musculoskeletal Diseases
Interventions: OTHER: Very low carbohydrate ketogenic diet|OTHER: Mediterranean diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Platinum Resistant Ovarian Cancer Evaluation of Doxil and Vintafolide (MK-8109, EC145) Combination Therapy (8109-009, EC-FV-04)
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Vintafolide|DRUG: pegylated liposomal doxorubicin (PLD)|OTHER: EC20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: International Clinical Study of Zhizhu Kuanzhong Capsule
Status: RECRUITING
Conditions: Functional Dyspepsia|Postprandial Distress Syndrome
Interventions: DRUG: Zhizhu Kuanzhong Capsule|DRUG: Zhizhu Kuanzhong Placebo Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ProMRI Study of the Iforia ICD System (Phase C)
Status: COMPLETED
Conditions: Implantable Cardioverter-Defibrillator With Magnetic Resonance Imaging
Interventions: DEVICE: Patients with a ProMRI ICD System|OTHER: Magnetic Resonance Imaging (MRI) scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Debio 1143 in Combination With Carboplatin and Paclitaxel in Patient With Advanced Solid Malignancies
Status: TERMINATED
Conditions: Solid Tumors
Interventions: DRUG: Part A: Debio 1143|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Part B: Debio 1143
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clomiphene Plus N-acetyl Cysteine for Induction of Ovulation in Newly Diagnosed Pcos.
Status: COMPLETED
Conditions: PCOS
Interventions: DRUG: NAC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neurofeedback Training for Older Adults With Mild Cognitive Impairment: a Protocol Study
Status: UNKNOWN
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Analysis of Large Macular Hole Surgeries
Status: UNKNOWN
Conditions: Macular Holes
Interventions: PROCEDURE: the Cover group|PROCEDURE: the Fill group|PROCEDURE: the peeling group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CNCT19 Following ASCT in Patients With Relapsed or Refractory B-cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Large B-cell Lymphoma
Interventions: BIOLOGICAL: CNCT19|DRUG: Gemcitabine Injection|DRUG: busulfan|DRUG: Melphalan Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of a Therapeutic Vaccine Candidate in Patients With Localized Breast Cancer at High-Risk of Relapse
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: MAG-TN3 + AS15
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of 17-Beta Estradiol in Treatment of Atrophic Vaginitis
Status: COMPLETED
Conditions: Menopause|Postmenopausal Vaginal Atrophy
Interventions: DRUG: estradiol, 10 mcg|DRUG: estradiol, 25 mcg|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Physiotherapy Treatment for Patients With Subacromial Pain Compared to Usual Physiotherapy in Primary Care
Status: NOT_YET_RECRUITING
Conditions: Subacromial Pain Syndrome|Shoulder Pain|Rotator Cuff Syndrome
Interventions: OTHER: Digital Physiotherapy (diSAID)|OTHER: Traditional Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: L19IL2/L19TNF in Skin Cancer Patients
Status: RECRUITING
Conditions: BCC - Basal Cell Carcinoma|SCC - Squamous Cell Carcinoma|Merkel Cell Carcinoma|Keratoacanthoma of Skin|Malignant Adnexal Tumors of the Skin (MATS)|Tumors From Cutaneous T-cell Lymphoma (CTCL)|Kaposi Sarcoma
Interventions: DRUG: L19IL2/L19TNF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Inflammatory Reaction in Standard vs Single Port Cholecystectomy for Uncomplicated Cholelithiasis
Status: COMPLETED
Conditions: Cholelithiasis|Inflammatory Response
Interventions: OTHER: Single incision laparoscopic cholecystectomy|OTHER: Laparoscopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Injections in the Diagnosis and Treatment of Lumbar Facet Syndrome
Status: UNKNOWN
Conditions: Facet Joint Pain|Facet Syndrome of Lumbar Spine|Facet Joints; Degeneration
Interventions: DIAGNOSTIC_TEST: FACET JOINT UNDER CT GUIDANCE|DIAGNOSTIC_TEST: NERVE BLOCK UNDER CT GUIDANCE|DIAGNOSTIC_TEST: FACET JOINT UNDER FLUOROSCOPY GUIDANCE|DIAGNOSTIC_TEST: NERVE BLOCK UNDER FLUOROSCOPY GUIDANCE|DIAGNOSTIC_TEST: FACET JOINT UNDER ULTRASOUND GUIDANCE|DIAGNOSTIC_TEST: NERVE BLOCK UNDER ULTRASOUND GUIDANCE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transplantation of Bone Marrow Mesenchymal Stromal Cells for Periodontal Regeneration
Status: ENROLLING_BY_INVITATION
Conditions: Chronic Periodontal Disease|Aggressive Periodontitis
Interventions: BIOLOGICAL: Transplantation of allogeneic MSCs in periodontal disease
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Treatment of Sleep Apnea in Patients With Paroxysmal Atrial Fibrillation
Status: COMPLETED
Conditions: Sleep Disordered Breathing|Sleep Apnea|Paroxysmal Atrial Fibrillation
Interventions: DEVICE: PAP (CPAP or ASV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Artificial Intelligence and Dysplasia Detection in Inflammatory Bowel Disease (EIIDISIA Study)
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases|Dysplasia
Interventions: DEVICE: CADe system|DEVICE: NBI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Methoxyamine and Temozolomide in Treating Patients With Recurrent Glioblastoma
Status: TERMINATED
Conditions: Adult Brain Glioblastoma
Interventions: OTHER: Treatment|DRUG: Methoxyamine|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Lidocaine Patch 1.8% Lidocaine Patch 5% (Lidoderm®) in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lidocaine patch 1.8%|DRUG: Lidocaine 5% patch|DRUG: Lidocaine 2% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Oral Curcumin Administration to Remit Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Curcumin|DIETARY_SUPPLEMENT: Hydrolyzed collagen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacology Study of Atezolizumab Alone and in Combination With Bacille Calmette-Guérin (BCG) in High-Risk Non-Muscle-Invasive Bladder Cancer (NMIBC) Participants
Status: TERMINATED
Conditions: Bladder Cancer
Interventions: DRUG: Atezolizumab|BIOLOGICAL: Bacille Calmette-Guérin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PAK4 and NAMPT in Patients With Solid Malignancies or NHL (PANAMA)
Status: TERMINATED
Conditions: Solid Tumors|NHL
Interventions: DRUG: KPT-9274|DRUG: Niacin ER|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Epigallocatechin Gallate (EGCG) in Healthy, Young Adults
Status: COMPLETED
Conditions: Cognitive Function|Mood
Interventions: DIETARY_SUPPLEMENT: EGCG|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PPI Sequencing Study
Status: COMPLETED
Conditions: Gastro-Oesophageal Reflux Disease
Interventions: DRUG: Esomeprazole|PROCEDURE: Physical exam|PROCEDURE: Pregnancy test if applicable
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Haploidentical Bone Marrow Transplant With Post-Transplant Cyclophosphamide for Patients With Severe Aplastic Anemia
Status: RECRUITING
Conditions: Severe Aplastic Anemia
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|RADIATION: Total Body Irradiation|DRUG: Rabbit ATG|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Phenolic Compounds in Osteoarthritis; a Nutritional Intervention
Status: COMPLETED
Conditions: Symptomatic Knee Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: Ascorbic acid / phytochemical supplement|DIETARY_SUPPLEMENT: Ascorbic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison the Effects of Dexamethasone and Loteprednol on Epithelial Healing
Status: COMPLETED
Conditions: Epithelial Defect After Phototherapeutic Keratectomy
Interventions: DRUG: Dexamethasone|DRUG: Loteprednol etabonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: O6-Benzylguanine and Carmustine Implants in Treating Patients With Recurrent Malignant Glioma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: O6-benzylguanine|DRUG: polifeprosan 20 with carmustine implant|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Single Retainer All-Ceramic Resin-bonded Fixed Dental Protheses
Status: UNKNOWN
Conditions: Restauration in Situ|Final Loss of Restauration|Debonded Restauration
Interventions: OTHER: Multilink|OTHER: Panavia 21 TC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compression Is Life In Cardiac Arrest - Human Study (CILICA-HS).
Status: RECRUITING
Conditions: Cardiac Arrest|Cardiopulmonary Resuscitation
Interventions: OTHER: Guidance of the External Chest Compression|OTHER: Rhythm of a relay 4 minutes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Combination Chemotherapy With or Without Vismodegib in Treating Patients With Advanced Stomach Cancer or Gastroesophageal Junction Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Gastroesophageal Junction|Adenocarcinoma of the Stomach|Recurrent Gastric Cancer|Stage IIIA Gastric Cancer|Stage IIIB Gastric Cancer|Stage IIIC Gastric Cancer|Stage IV Gastric Cancer
Interventions: DRUG: oxaliplatin|DRUG: leucovorin calcium|DRUG: fluorouracil|OTHER: placebo|DRUG: vismodegib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Trial rHuKFG for the Treatment of Steroid Refractory Gastrointestinal Acute GVHD
Status: TERMINATED
Conditions: Acute Graft Versus Host Disease
Interventions: DRUG: Recombinant Human Keratinocyte Growth Factor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IVUS Study for SV Graft: Y-composite vs Aortocoronary Conduit
Status: COMPLETED
Conditions: Coronary Artery Disease|Morphologic Change
Interventions: PROCEDURE: graft configuration in coronary artery bypass grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3BNC117-LS and 10-1074-LS Plus N-803 (bNAb+N-803)
Status: RECRUITING
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: 3BNC117-LS|DRUG: 10-1074-LS|DRUG: N803
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Complementary Medicine Practices in Chronic Low Back Pain: Randomized Controlled Trial
Status: COMPLETED
Conditions: Back Pain|Leeches|Chronic Pain
Interventions: OTHER: Leech|OTHER: Conventional Physiotherapy|OTHER: Kinesiotape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radioiodine Planar and a SPECT/CT Imaging With Iodine-123 for Evaluation of Follicular Thyroid Nodules Prior to Surgery
Status: RECRUITING
Conditions: Thyroid Gland Follicular Carcinoma
Interventions: PROCEDURE: Computed Tomography|RADIATION: Iodine I-123|PROCEDURE: Planar Imaging|PROCEDURE: Single Photon Emission Computed Tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tenecteplase in Patients With COVID-19
Status: COMPLETED
Conditions: COVID-19|Respiratory Failure|ARDS
Interventions: DRUG: Tenecteplase|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Intrathecal Administration of Thiotepa in Combination With Methotrexate in Breast Cancer With Leptomeningeal Metastasis
Status: RECRUITING
Conditions: Leptomeningeal Metastasis of Breast Cancer
Interventions: DRUG: Intrathecal Administration of Thiotepa in Combination with Methotrexate via the Ommaya Reservoir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Assess Safety and Immunogenicity of a Synthetic Vaccine Against Streptococcus Pyogenes
Status: WITHDRAWN
Conditions: Rheumatic Fever
Interventions: BIOLOGICAL: Streptococcus pyogenes vaccine (50 µg)|BIOLOGICAL: Streptococcus pyogenes vaccine (100 µg)|BIOLOGICAL: Streptococcus pyogenes vaccine (200 µg)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Multi-modal Approach to Addressing Cardiovascular Risk and Building Resilience in Youths With Psychosis
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders
Interventions: OTHER: M3 Program|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Different Rapid Maxillary Expansion Appliances on Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea Syndrome|Rapid Maxillary Expansion
Interventions: PROCEDURE: Rapid Maxillary Expansion Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peer-Presented Versus Mental Health Service Provider-Presented Mental Health Outreach Programs for University Students
Status: COMPLETED
Conditions: Stress|Self Efficacy|Social Support|Social Connectedness|Mindfulness|Quality of Life
Interventions: BEHAVIORAL: Stress and Coping Online Outreach Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cytotoxic T-Lymphocytes for EBV-positive Lymphoma, GRALE
Status: RECRUITING
Conditions: Hodgkin's Disease|Non-Hodgkin's Lymphoma|Lymphoproliferative Disease|Lymphoma
Interventions: BIOLOGICAL: EBV-specific T cells: A|BIOLOGICAL: EBV-specific T cells: B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin and Prednisolone (Ox-P) for Patients With Relapsed or Refractory Marginal Zone B-cell Lymphoma(MZL)
Status: COMPLETED
Conditions: B-cell Lymphomas
Interventions: DRUG: Oxaliplatin, Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antimicrobial Prophylaxis in Patients Who Underwent a Transurethral Resection of Bladder (TURB)
Status: COMPLETED
Conditions: Urinary Tract Infections|Bladder Cancer|Urologic Surgical Procedures
Interventions: DRUG: Fosfomycin Tromethamine 3G Sachet|DRUG: Amikacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A First-in-Human, Phase 1 Dose-Escalation and Cohort Expansion Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BJ-005 in Patients With Advanced Solid Tumor or Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumor or Lymphoma
Interventions: BIOLOGICAL: BJ-005
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Symbicort pMDI Administered Once Daily in Adolescents and Adults During 12 Weeks - STEM
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: budesonide/formoterol|DRUG: budesonide and placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) Renal Impairment Study 2 (MK-0616-020)
Status: COMPLETED
Conditions: Hypercholesterolaemia
Interventions: DRUG: Enlicitide Decanoate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Brisk Walking Combined With Ingestion of a Lipid-lowering Drug Improve Fat Metabolism in Muscle?
Status: ACTIVE_NOT_RECRUITING
Conditions: Pre Diabetes
Interventions: DIAGNOSTIC_TEST: Body Composition|DIAGNOSTIC_TEST: Maximal aerobic fitness test|DIAGNOSTIC_TEST: Oral glucose tolerance test|OTHER: Muscle biopsy|OTHER: Blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of the Safety and Efficacy of Infliximab(REMICADE ) in Pediatric Patients With Moderately to SeverelyActive Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: BIOLOGICAL: infliximab|BIOLOGICAL: infliximab|BIOLOGICAL: infliximab|BIOLOGICAL: infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Community-Based Behaviour Change Communication Model to Prevent Cholangiocarcinoma in Khon Kaen, Thailand
Status: NOT_YET_RECRUITING
Conditions: Cholangiocarcinoma|Liver Fluke-Related Cholangiocarcinoma|Opisthorchiasis
Interventions: BEHAVIORAL: eCHEC program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Endotoxin-induced Inflammatory and Behavioral Responses and Predictors of Individual Differences
Status: COMPLETED
Conditions: Sickness Behavior
Interventions: BIOLOGICAL: Endotoxin|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features
Status: COMPLETED
Conditions: Adrenocortical Carcinoma|Gastrointestinal Carcinoid Tumor|Kidney Cancer|Neuroblastoma|Retinoblastoma|Sarcoma
Interventions: BIOLOGICAL: Seneca Valley virus-001|DRUG: cyclophosphamide|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An N-of-1 Study of Homeopathic Treatment of Fatigue in Patients Receiving Chemotherapy
Status: COMPLETED
Conditions: Fatigue|Effects of Chemotherapy
Interventions: OTHER: Homeopathic medicine|OTHER: Unmedicated lactose/sucrose globule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vildagliptin Versus Sitagliptin - Differences in Fasting Plasma Glucose Lowering Efficacy
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: Vildagliptin|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Concentrated Endogenous Autologous Adipose Stromal Cells in Fat Grafts for Craniofacial Trauma
Status: TERMINATED
Conditions: Craniofacial Injuries
Interventions: PROCEDURE: Fat Grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Optimal Head Position for Distributing Topical Nasal Medication Using the Mucosal Atomization Device
Status: COMPLETED
Conditions: Sinusitis
Interventions: PROCEDURE: Lying Head Back Position|PROCEDURE: Head Down and Forward Position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel and Thalidomide as Second-Line Therapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: docetaxel|DRUG: thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Understand Risk Information to Support and Empower
Status: ENROLLING_BY_INVITATION
Conditions: Diabetes, Gestational|Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Standard Health Information|BEHAVIORAL: Values Affirmation (VA)|BEHAVIORAL: Tailored Risk Information (TRI)|BEHAVIORAL: Motivational Interviewing-based (MI)|BEHAVIORAL: Action planning (AP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Early Methicillin-resistant Staphylococcus Aureus (MRSA) Therapy in Cystic Fibrosis (CF)
Status: TERMINATED
Conditions: Cystic Fibrosis|Methicillin-resistant Staphylococcus Aureus
Interventions: DRUG: Rifampin|DRUG: Trimethoprim/Sulfamethoxazole|DRUG: Minocycline|DRUG: Mupirocin|DRUG: chlorhexidine gluconate oral rinse|DRUG: 2% Chlorhexidine solution wipes|BEHAVIORAL: Environmental Decontamination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Neoadjuvant Chemoradiation for Potentially Resectable Pancreas Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Avastin (bevacizumab)|DRUG: Gemzar (Gemcitabine)|RADIATION: external beam radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Venous Distension Reflex and Orthostatic Hypertension
Status: RECRUITING
Conditions: Blood Pressure
Interventions: OTHER: Tilt + external pressure|OTHER: Tilt + no external pressure.|OTHER: Limb occlusion + negative pressure|OTHER: Limb occlusion + no negative pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of SPD476 in Maintaining Remission in Patients With Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: SPD476|DRUG: Asacol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LEO 80185 Gel (Calcipotriol Hydrate Plus Betamethasone Dipropionate) in Japanese Subjects With Psoriasis
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: LEO 80185 gel|DRUG: Dovobet ® ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fruquintinib and Albumin-paclitaxel Combined With or Without PD-1 Antibody in 2nd-line Treatment of G/GEJ Adenocarcinoma
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: PD-1inhibitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Telemedicine Intervention in Patients With Chronic Pain in PD
Status: RECRUITING
Conditions: Parkinson's Disease
Interventions: BEHAVIORAL: Physical exercise intervention|BEHAVIORAL: Cognitive exercise intervention|BEHAVIORAL: Health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Metformin Glycinate Compared to Metformin Hydrochloride on the Progression of Type 2 Diabetes
Status: SUSPENDED
Conditions: Type 2 Diabetes
Interventions: DRUG: Metformin glycinate|DRUG: Metformin Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mobilizing Doulas to Empower Black Women in Post-partum Diabetes Prevention
Status: NOT_YET_RECRUITING
Conditions: Gestational Diabetes|Type2 Diabetes
Interventions: BEHAVIORAL: DPP only|BEHAVIORAL: Diabetes Prevention Program (DPP) online + doula divas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: An Open-label Study Evaluating Ofatumumab Treatment Effectiveness and PROs in Subjects With RMS Transitioning From Fumarate-based RMS Approved Therapies or Fingolimod to Ofatumumab
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsing Multiple Sclerosis
Interventions: BIOLOGICAL: Ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Treatment Protocol for Lower Urinary Tract Symptoms in General Practice
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia|Lower Urinary Tract Symptoms
Interventions: PROCEDURE: current usual care|PROCEDURE: treatment protocol with clear indications for therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mifepristone Versus Osmotic Dilators in Conjunction With Misoprostol for Cervical Preparation Prior to D&E at 14-19 Weeks
Status: WITHDRAWN
Conditions: Legally Induced Abortion Without Mention of Complication
Interventions: DRUG: Misoprostol|DRUG: Mifepristone|DEVICE: Hygroscopic cervical dilators
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of a Vaccine for Pneumonia in Adults and Toddlers in Kenya
Status: COMPLETED
Conditions: Pneumonia
Interventions: BIOLOGICAL: PATH-wSP|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: INVEST: INternational VErapamil SR Trandolapril STudy
Status: COMPLETED
Conditions: Hypertension|Coronary Artery Disease
Interventions: DRUG: Verapamil SR/Trandolapril/Hydrochlorothiazide (HCTZ)|DRUG: Atenolol/HCTZ/Trandolapril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindfulness Based Emotion Regulation Therapy in the Treatment of Depressive Rumination
Status: UNKNOWN
Conditions: Depressive Disorder|Depression|Rumination
Interventions: BEHAVIORAL: Mindfulness based Emotion regulation therapy (MBERT) - Treatment as usual (TAU)|OTHER: Treatment as usual (TAU) - Mindfulness based Emotion regulation therapy (MBERT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study Between SKF101804 Cefixime 200 Milligram (mg)/5 Milliliter (mL) Suspension Versus Cefixime 200 mg/5 mL Suspension Reference Product in Healthy Adult Subjects Under Fasting Conditions
Status: COMPLETED
Conditions: Infections, Bacterial
Interventions: DRUG: Test formulation A|DRUG: Reference formulation B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects and Safety of Topical Spironolactone Ophthalmic Solution, 0.005 mg/cc in Subjects With Dry Eye Disease
Status: NOT_YET_RECRUITING
Conditions: Dry Eye Disease
Interventions: DRUG: Topical spironolactone ophthalmic solution, 0.005 mg/cc|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone for Cardiac Surgery Trial
Status: COMPLETED
Conditions: Systemic Inflammatory Response Syndrome|Cardiac Diseases|Postoperative Complications
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Pharmacology Study to Evaluate the Total Systemic Exposure and Lung Bioavailability of CHF 5993 pMDI Combination in Healthy Volunteers
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: CHF 5993 HS 200/6/25 pMDI|DRUG: CHF 5993 MS 100/6/25 pMDI|DRUG: CHF 5993 HS 200/6/25 pMDI + Charcoal Block|DRUG: CHF 5993 MS 100/6/25 pMDI + Charcoal Block|DRUG: Placebo pMDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: M6620 First in Human Study
Status: COMPLETED
Conditions: Advanced Solid Tumor
Interventions: DRUG: M6620|DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Etoposide|DRUG: Carboplatin|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of PICO Compared to Opsite Post-Op Visible on Surgical Wound in Patients at High Risk of Local Complications, Undergoing Hip Arthroplasty
Status: NOT_YET_RECRUITING
Conditions: Evaluate Postsurgical Hematoma
Interventions: DEVICE: PICO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the International Diffusion of the European Code Against Cancer Through Mobile Telephony
Status: TERMINATED
Conditions: Prevention|Health Behavior
Interventions: BEHAVIORAL: App message|BEHAVIORAL: SMS message|BEHAVIORAL: Internet|BEHAVIORAL: Whithout internet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intratumoral CAVATAK (CVA21) and Pembrolizumab in Patients With Advanced Melanoma (VLA-011 CAPRA)
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: CAVATAK|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Transcutaneous Electrical Acustimulation on Small Bowel Preparation for Capsule Endoscopy
Status: NOT_YET_RECRUITING
Conditions: Quality of Small Bowel Preparation
Interventions: DEVICE: digital stimulators (SNM-FDC01, Ningbo MaidaMedical Device, Inc, Ningbo, China)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With High-Risk Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: paclitaxel|DRUG: thiotepa|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telerehabilitation Exercise: Effects on Maternal Quality of Life, Fetal and Neonatal Health.
Status: RECRUITING
Conditions: Gestational Diabetes Mellitus in Pregnancy
Interventions: OTHER: telerehabilitation exercise|OTHER: routine medical care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The CONFORM Pivotal Trial
Status: SUSPENDED
Conditions: Atrial Fibrillation|Stroke
Interventions: DEVICE: CLAAS|DEVICE: WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Alternative Treatment for Cervical Intraepithelial Neoplasia Using the Focal Loop Electrosurgical Excision Procedure
Status: COMPLETED
Conditions: High-grade Cervical Intraepithelial Neoplasia
Interventions: PROCEDURE: Focal LEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Olaparib for the Treatment of Castration Resistant Prostate Adenocarcinoma
Status: TERMINATED
Conditions: Castration-Resistant Prostate Carcinoma|Prostate Adenocarcinoma
Interventions: DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Whether Survodutide Helps People Living With Obesity or Overweight and With a Confirmed or Presumed Liver Disease Called Non-alcoholic Steatohepatitis (NASH) to Reduce Liver Fat and to Lose Weight
Status: RECRUITING
Conditions: Obesity|Non-Alcoholic SteatoHepatitis (NASH)
Interventions: DRUG: Survodutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of SAGE-718 in Participants With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease (AD)
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Mild Dementia|Alzheimer's Disease
Interventions: DRUG: SAGE-718|DRUG: SAGE-718-matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adenosine vs AF Termination for Paroxysmal AF Ablation
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: PROCEDURE: Adenosine test|PROCEDURE: Termination of AF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Taselisib in Overgrowth
Status: TERMINATED
Conditions: PIK3CA-Related Overgrowth
Interventions: DRUG: Taselisib (GDC0032)|DRUG: Taselisib (GDC0032)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Aggression Among People With an Intellectual Disability
Status: COMPLETED
Conditions: Aggression|Intellectual Disability
Interventions: DIETARY_SUPPLEMENT: Multivitamin, mineral & n-3 FA|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reduced Oestrogen Dosage to Improve the Outcome of Frozen-thawed Embryo Transfer
Status: RECRUITING
Conditions: FET
Interventions: OTHER: Low oestrogen dosage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects and Costs of Respiratory Muscle Training in Institutionalized Elderly People
Status: COMPLETED
Conditions: Muscle Weakness|Syndrome; Institutionalization|Respiratory Morbidity|Cardiovascular Morbidity
Interventions: DEVICE: Threshold® Inspiratory Muscle Trainer (treatment).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Radiological Evaluation of Patients With DDD Following TLIF With 3-D Printed Titanium Cage
Status: COMPLETED
Conditions: Intervertebral Disc Disease
Interventions: DEVICE: Stryker Tritanium Spinal System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT