pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: 4'-Iodo-4'-Deoxydoxorubicin in Treating Patients With Primary Systemic Amyloidosis
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: 4'-iodo-4'-deoxydoxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Dupilumab as Add-On Therapy for Hypereosinophilic Syndrome With Partial Clinical Response to Eosinophil-Depleting Biologic Agents
Status: NOT_YET_RECRUITING
Conditions: Hypereosinophilic Syndrome
Interventions: BIOLOGICAL: dupilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Robot-assisted Arm Training on Respiratory Muscle Strength, Activities of Daily Living and Quality of Life in Stroke Patients: A Single-blinded Randomized Controlled Trial
Status: UNKNOWN
Conditions: Stroke
Interventions: OTHER: Robot assisted arm training|OTHER: Conventional rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Liquid Zinc Supplementation and Dispersible Zinc Tablets on Plasma Zinc Concentration
Status: COMPLETED
Conditions: Zinc Deficiency
Interventions: DIETARY_SUPPLEMENT: Liquid zinc syrup|DIETARY_SUPPLEMENT: Zinc tablet|DIETARY_SUPPLEMENT: Liquid placebo supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Acupuncture on Patients With Noise-induced Hearing Loss
Status: UNKNOWN
Conditions: Electroacupuncture|Noise Induced Hearing Loss|Hearing Loss, Noise-Induced
Interventions: DEVICE: electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Futibatinib in Combination With Durvalumab Prior to Cystectomy for the Treatment of Muscle-Invasive Bladder Cancer Patients Who Are Ineligible for Cisplatin-based Therapy
Status: NOT_YET_RECRUITING
Conditions: Bladder Urothelial Carcinoma|Muscle Invasive Bladder Carcinoma|Stage II Bladder Cancer AJCC v8|Stage IIIA Bladder Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|BIOLOGICAL: Durvalumab|DRUG: Futibatinib|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Radical Cystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ganetespib, Paclitaxel, Trastuzumab and Pertuzumab for Metastatic Human Epidermal Growth Factor Receptor 2 Positive Breast Cancer
Status: COMPLETED
Conditions: HER2-positive Breast Cancer|Male Breast Cancer|Recurrent Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: ganetespib|DRUG: paclitaxel|BIOLOGICAL: trastuzumab|BIOLOGICAL: pertuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Garlic Extracts on Changes in Cerebral Blood Flow
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Garlic extracts|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Two Oral Doses of GSK557296 in a Study in Men With Premature Ejaculation
Status: COMPLETED
Conditions: Premature Ejaculation
Interventions: DRUG: GSK557296|DRUG: GSK557296|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Augmenting Cognitive Behavioral Therapy With Inhibitory Control Training
Status: UNKNOWN
Conditions: Binge-Eating Disorder|Bulimia Nervosa
Interventions: BEHAVIORAL: CBT|BEHAVIORAL: ICT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Psychological Intervention to Promote Acceptance and Adherence to NIV in People With COPD
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: BEHAVIORAL: Psychological Intervention|BEHAVIORAL: Videos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Efficacy of Dapagliflozin and Saxagliptin in Patients With Type 2 Diabetes Mellitus (T2DM) Aged 10 to Below 18 Years Old
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Dapagliflozin|DRUG: Saxagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Linperlisib-based Treatment Regimen in Newly Diagnosed Nodal T-follicular Helper Cell Lymphoma (nTFHL)
Status: RECRUITING
Conditions: Nodal T-follicular Helper Cell Lymphoma
Interventions: DRUG: linperlisib combined with CHOP regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Optimal Dosing Conditions for a Long Acting GLP-1 Analogue in Healthy Male Subjects
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2|Healthy
Interventions: DRUG: semaglutide|DRUG: semaglutide|DRUG: semaglutide|DRUG: semaglutide|DRUG: semaglutide|DRUG: semaglutide|DRUG: semaglutide|DRUG: semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Effectiveness and Safety Study of CONCERTA® (Methylphenidate Hydrochloride) in the Treatment of Adolescents With Attention Deficit Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: methylphenidate hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Fosaprepitant Dimeglumine in Treating Patients With Nausea and Vomiting Caused By Chemotherapy
Status: TERMINATED
Conditions: Breakthrough Nausea and Vomiting|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: fosaprepitant dimeglumine|DRUG: systemic chemotherapy|OTHER: survey administration|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Low Viscosity Chloroprocaine Ophthalmic Gel 3% on the Bactericidal Action of Povidone-Iodine
Status: RECRUITING
Conditions: Antiseptic|Anesthesia, Local
Interventions: DRUG: Chloroprocaine ophthalmic gel 3%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Two Different Regimens of VELCADE in Combination With Dexamethasone, Thalidomide and Cyclophosphamide (VDT vs VDTC) in Newly Diagnosed Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: bortezomib, dexamethasone, and thalidomide|DRUG: bortezomib, dexamethasone, thalidomide, and cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Azficel-T for the Treatment of Restrictive Burn Scars
Status: TERMINATED
Conditions: Restrictive Burn Scars
Interventions: BIOLOGICAL: Autologous fibroblasts|BIOLOGICAL: placebo sterile saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Striving Towards EmPowerment and Medication Adherence (STEP-AD)
Status: COMPLETED
Conditions: HIV
Interventions: BEHAVIORAL: Experimental Intervention (STEP-AD)|BEHAVIORAL: Enhanced Treatment as Usual (E-TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing SD-tVEP and PERG Tests Between Patients With Glaucoma, Patients With High Eye Pressure and "Normal" Patients
Status: COMPLETED
Conditions: Glaucoma
Interventions: DIAGNOSTIC_TEST: Short Duration Transient Visual Evoked Potential (SDtVEP)|DIAGNOSTIC_TEST: Pattern electroretinogram (PERG)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Influence Of Different Airflow Resistances On Drug Effect Of 50μg Salmeterol And 6 μg Formoterol
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: formoterol (TURBOHALER)|DRUG: Salmeterol (DISKUS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block for Post-thoracotomy Pain Control
Status: COMPLETED
Conditions: Post-thoracotomy Pain Syndrome
Interventions: PROCEDURE: Thoracic epidural analgesia|PROCEDURE: ESPB with levobupivacaine and dexmedetomedine|PROCEDURE: ESPB with levobupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immunoscintigraphy Using Radiolabeled Monoclonal Antibody in Finding Tumor Cells in Patients With Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: OTHER: pharmacological study|PROCEDURE: single photon emission computed tomography|RADIATION: iodine I 123 anti-CEA recombinant diabody T84.66
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Characterization of Diabetes Mellitus in Fibrous Dysplasia/McCune-Albright Syndrome
Status: WITHDRAWN
Conditions: McCune-Albright Syndrome|Fibrous Dysplasia|Intraductal Papillary Mucinous Neoplasm|Diabetes Mellitus
Interventions: PROCEDURE: Hyperinsulinemic Euglycemic Clamp and 2H20|PROCEDURE: Hyperglycemic Clamp|DIAGNOSTIC_TEST: Oral Glucose Tolerance Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Rufinamide in Pediatric Subjects 1 to Less Than 4 Years of Age With Lennox-Gastaut Syndrome Inadequately Controlled With Other Anti-epileptic Drugs
Status: COMPLETED
Conditions: Lennox-Gastaut Syndrome
Interventions: DRUG: Rufinamide|DRUG: Any other approved Antiepileptic Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maxillary Sinus Floor Augmentation With Different Grafting Materials
Status: COMPLETED
Conditions: Survival, Prosthesis|Peri-Implantitis|Patient Satisfaction
Interventions: PROCEDURE: Maxillary sinus floor augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Compare VKA vs LMWH in Patients With Anticoagulation Criteria and Episode of Gastrointestinal Bleeding.
Status: COMPLETED
Conditions: Acute Gastrointestinal Bleeding
Interventions: DRUG: warfarin|DRUG: Bemiparina
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Ergonomics Awareness Education and Exercise
Status: COMPLETED
Conditions: Ergonomics|Telerehabilitation|Musculoskeletal System Disorder|Quality of Life
Interventions: BEHAVIORAL: Asyncronized Exercise|PROCEDURE: Syncronized Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zanubrutinib, Ixazomib and Dexamethasone in Patients With Treatment Naive Waldenstrom's Macroglobulinemia
Status: RECRUITING
Conditions: Waldenström Macroglobulinemia
Interventions: DRUG: Zanubrutinib,Ixazomib and Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SPIRIT FIRST Clinical Trial of the Abbott Vascular XIENCE V® Everolimus Eluting Coronary Stent System
Status: COMPLETED
Conditions: Coronary Artery Disease|Everolimus|Vascular Disease|Myocardial Ischemia|Coronary Artery Stenosis
Interventions: DEVICE: Coronary artery drug eluting stent placement|DEVICE: Coronary artery stent placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: APX005M in Combination With Systemic Pembrolizumab in Patients With Metastatic Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: DRUG: APX005M|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Air Cleaners for Children and Adolescents With Asthma and Dog Allergy
Status: COMPLETED
Conditions: Asthma|Allergy
Interventions: DEVICE: IQAir Allergen 100 Air cleaners
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metformin Effect on Fracture Healing in Post-Menopausal Women
Status: COMPLETED
Conditions: Bone Fracture
Interventions: DRUG: Metformin Retard 850 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Potassium Oxalate and Potassium Nitrate and Post-bleaching Sensitivity
Status: COMPLETED
Conditions: Medicaments Substances in Therapeutic Use
Interventions: DEVICE: Potassium nitrate 2% gel|DEVICE: Potassium oxalate 5% gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Simtuzumab (GS-6624) in the Prevention of Progression of Liver Fibrosis in Adults With Primary Sclerosing Cholangitis (PSC)
Status: COMPLETED
Conditions: Primary Sclerosing Cholangitis (PSC)
Interventions: BIOLOGICAL: Simtuzumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment and Survival Continuation Study of Atamestane Plus Toremifene vs Letrozole in Advanced Breast Cancer
Status: TERMINATED
Conditions: Breast Neoplasms|Neoplasms, Hormone-Dependent
Interventions: DRUG: Atamestane|DRUG: toremifene|DRUG: letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) Study
Status: RECRUITING
Conditions: Cognitive Impairment|Alzheimer Disease|Vascular Cognitive Impairment|Dementia|Brain Diseases|Central Nervous System Diseases|Nervous System Diseases|Neurocognitive Disorders|Mental Disorders|Cognition Disorder
Interventions: BEHAVIORAL: Structured Lifestyle Intervention|BEHAVIORAL: Self-Guided Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Postoperative Noninvasive Ventilation After Upper Abdominal Surgery in Chronic Obstructive Lung Disease
Status: COMPLETED
Conditions: Acute Respiratory Failure Post Surgical (Diagnosis)
Interventions: DEVICE: NIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Self-management Adherence in Heart Failure Patients
Status: COMPLETED
Conditions: Heart Failure
Interventions: BEHAVIORAL: PATCH intervention|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Online Expert Peer Facilitation of the EVERYbody Project
Status: COMPLETED
Conditions: Body Image|Eating Disorder Symptom|Weight Bias
Interventions: BEHAVIORAL: EVERYbody Project-Connect|BEHAVIORAL: Self-Help Workbook
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Chemoprevention Study of an Investigational Drug in Men With High Grade Prostate Intraepithelial Neoplasia (PIN)
Status: COMPLETED
Conditions: Prostatic Intraepithelial Neoplasia
Interventions: DRUG: GTX-006 (Acapodene)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Two Non-invasive Neuromodulation Techniques as Synergistic Therapy to Cognitive Stimulation in Amnestic Mild Cognitive Impairment (aMCI)
Status: RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: DEVICE: 1. rTMS + CS|DEVICE: 2. rTMS Sham + CS|DEVICE: 3. tDCS + CS|DEVICE: 4. tDCS Sham + CS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoantigen Vaccines in Pancreatic Cancer in the Window Prior to Surgery
Status: RECRUITING
Conditions: Pancreas Cancer|Pancreatic Cancer|Cancer of the Pancreas
Interventions: BIOLOGICAL: Optimized neoantigen synthetic long peptide vaccine|BIOLOGICAL: Poly-ICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing the Efficiency and Implementation of Cash Transfers to Improve Adherence to Antiretroviral Therapy Phase II
Status: COMPLETED
Conditions: HIV (Human Immunodeficiency Virus)
Interventions: BEHAVIORAL: Conditional Cash Transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: OCT Technology Development to Assess Ocular Integrity and Characterize Ocular Integrity and Intraocular Scatterers
Status: COMPLETED
Conditions: Uveitis
Interventions: DEVICE: hand-held swept source optical coherence tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Study of Anlotinib in Advanced Non-squamous NSCLC Patients in the Elderly Without Systemic Chemotherapy (ALTER-L006)
Status: UNKNOWN
Conditions: Advanced Non-squamous NSCLC
Interventions: DRUG: Anlotinib Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Timely Interventions to Enable and Reach Patients With Heart Failure, and Their Caregivers With Palliative Care
Status: RECRUITING
Conditions: Heart Failure
Interventions: OTHER: TIER-HF-PC|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Early Switch From First-Line Docetaxel/Prednisone to Cabazitaxel/Prednisone and the Opposite Sequence, Exploring Molecular Markers in Men With Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Status: COMPLETED
Conditions: Prostate Cancer Metastatic
Interventions: DRUG: DOCETAXEL (XRP6976)|DRUG: CABAZITAXEL (XRP6258)|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Point of Care Polymerase Chain Reaction (PCR) Diagnostics of Respiratory Tract Infections in General Practice
Status: RECRUITING
Conditions: Respiratory Tract Infections
Interventions: DIAGNOSTIC_TEST: POC PCR-test device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Vitamin D Supplement Before and During Pregnancy on Birth Weight
Status: UNKNOWN
Conditions: Birth Weight|Vitamin D Deficiency|Pregnancy
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol 35 µg per day|OTHER: placebo tablet|DIETARY_SUPPLEMENT: Cholecalciferol (Vitamin D3) 70 µg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between XELOX and S1, Oxaliplatin and Docetaxel as Neoadjuvant Chemotherapy for Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: Oxaliplatin|DRUG: capecitabine|DRUG: S1|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simplified Insulin Regimen for the Elderly
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Insulin Glargine|DRUG: Insulin Glargine|DRUG: Insulin Aspart|DRUG: Insulin Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Therapy as Adjunct to Revascularization
Status: WITHDRAWN
Conditions: Coronary Arteriosclerosis|Coronary Artery Bypass Graft|Myocardial Revascularization
Interventions: PROCEDURE: Autologous stem cell therapy|PROCEDURE: CABG|RADIATION: CMRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Uric Acid Decrement on Endothelial Function in Patients With Chronic Renal Failure
Status: COMPLETED
Conditions: Hyperuricemia|Chronic Kidney Disease
Interventions: DRUG: allopurinol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Trial to Investigate Immune Responses Elicited by a Liquid Formulation of Influenza Virus Vaccine(CAIV-T)in Healthy Adults Aged 18 to 59 and Healthy Adults Aged 60 Years and Older
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: CAIV-T or TIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Cognitive Behavioral Therapy Plus Nutritional Counseling in Promoting Weight Loss in People With Binge Eating Disorder
Status: COMPLETED
Conditions: Binge Eating Disorder|Obesity|Overweight
Interventions: BEHAVIORAL: Cognitive behavioral therapy plus general nutrition counseling (CBT+GN)|BEHAVIORAL: Cognitive behavioral therapy plus low energy density diet counseling (CBT+LED)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab, Docetaxel, and Carboplatin in Treating Women With Stage II, Stage III, or Inflammatory Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: herceptin|DRUG: carboplatin|DRUG: docetaxel|PROCEDURE: conventional surgery|PROCEDURE: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dance for People With Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease|Quality of Life|Sleep Disorder|Gait Disorders, Neurologic|Mobility Limitation
Interventions: OTHER: Binary rhythm|OTHER: Quaternary rhythm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: New Truncal Nerve Blocks for Thoracoscopic Surgery and Open Heart Surgery.
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: DRUG: Ropivacaine|DRUG: Sodium chloride 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of FE 999049 in Controlled Ovarian Stimulation in India Women
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Follitropin Delta (FE 999049)|DRUG: Follitropin Alfa (GONAL-F)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rectal Balloon Training in Female Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: OTHER: Rectal Balloon Training|OTHER: Pelvic floor muscle training (PFMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Pitavastatin and Atorvastatin in High Risk Hypercholesterolemic Patients
Status: UNKNOWN
Conditions: Hyperlipidemia
Interventions: DRUG: Pitavastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hydroxyapatite (HA) Coating Versus Plasma Porous Spray (PPS) in Press-fit Acetabular Components Early Outcomes With DEXA
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: G7 HA Acetabular Component|DEVICE: G7 PPS Acetabular Component
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of an Extract of Naringenin
Status: COMPLETED
Conditions: Safety Issues|Pharmacokinetics
Interventions: DIETARY_SUPPLEMENT: Naringenin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Histamine H1 Receptor Antagonist, Clemastin, on PACAP38 Induced Headache in Migraine Patients
Status: COMPLETED
Conditions: Migraine Without Aura
Interventions: DRUG: PACAP38
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Intubation Conditions Following BX1000 or Rocuronium in Subjects Undergoing Surgery
Status: COMPLETED
Conditions: Neuromuscular Blockade|Anesthesia|Surgery
Interventions: DRUG: BX1000|DRUG: Rocuronium Bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer
Status: COMPLETED
Conditions: Chronic Insertional Achilles Tendonitis
Interventions: PROCEDURE: Achilles decompression & debridement|PROCEDURE: Achilles decompression and debridement with FHL transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Negative Pressure Therapy, Minimally Invasive and Accessible Technique in the Treatment of Massive Subcutaneous Emphysema in COVID-19 or Non Infected Critical Patients
Status: COMPLETED
Conditions: Subcutaneous Emphysema|Covid19
Interventions: DEVICE: Vçac
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Single Centre Study to Compare the Efficacy and Safety of Femtosecond Laser-Assisted Versus Manual Cataract Surgery
Status: COMPLETED
Conditions: Cataract
Interventions: PROCEDURE: Lens Fragmentation by means of a femtosecondlaser|PROCEDURE: Manual Phacoemulsification
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study to Evaluate the Safety, Tolerability, and Immunogenicity of Multiple Production Lots and Dose Levels of BNT162b2 RNA-Based COVID-19 Vaccines Against COVID-19 in Healthy Participants
Status: COMPLETED
Conditions: SARS-CoV-2 Infection|COVID-19
Interventions: BIOLOGICAL: BNT162b2|BIOLOGICAL: BNT162b2.B.1.351
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Focal Accumulation of Iron in Cerebral Regions in Early ALS (Amyotrophic Lateral Sclerosis) Patients
Status: COMPLETED
Conditions: ALS (Amyotrophic Lateral Sclerosis)|Iron Overload
Interventions: DRUG: Deferiprone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Cobimetinib Plus Atezolizumab Versus Pembrolizumab in Participants With Previously Untreated Advanced BRAFv600 Wild-Type Melanoma
Status: TERMINATED
Conditions: Advanced BRAFV600 Wild-type Melanoma
Interventions: DRUG: Cobimetinib|DRUG: Atezolizumab|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study to Assess Glycosylated Hemoglobin Changes After 6 Months of Treatment With Pioglitazone.
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Pioglitazone and sulphonylurea|DRUG: Pioglitazone and sulphonylurea|DRUG: Pioglitazone and metformin|DRUG: Pioglitazone and metformin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Direct and Video Laryngoscope During Endotracheal Intubation in Sellick and Trendelenburg Position
Status: COMPLETED
Conditions: Intubation;Difficult
Interventions: OTHER: Macintosh in sniffing position|OTHER: Macintosh in Trendelenburg position and Sellick position|OTHER: AceScope in Trendelenburg position and Sellick position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Assess Efficacy and Safety of HL036 in Subjects With Dry Eyes
Status: COMPLETED
Conditions: Dry Eye
Interventions: BIOLOGICAL: HL036 Ophthalmic Solution|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CRTE7A2-01 TCR-T Cells for HPV-16 Positive Advanced Cancers
Status: NOT_YET_RECRUITING
Conditions: Cervical Cancer|Anal Cancer|Head and Neck Cancers|Other Solid Tumors
Interventions: DRUG: CRTE7A2-01 TCR-T cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quizartinib With Standard of Care Chemotherapy and as Continuation Therapy in Patients With Newly Diagnosed FLT3-ITD (+) Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Leukemia
Interventions: DRUG: Chemotherapy|DRUG: Quizartinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Ticagrelor on Abdominal Aortic Aneurysm (AAA) Expansion
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: DRUG: Ticagrelor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3462817 in Participants With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Placebo|DRUG: LY3462817
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Better Together Physician Coaching to Mitigate Burnout in Male-Identifying Trainees
Status: COMPLETED
Conditions: Burnout, Professional|Self Compassion|Flourishing|Imposter Syndrome|Moral Injury
Interventions: BEHAVIORAL: Better Together Physician Coaching Program|BEHAVIORAL: No intervention - placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Using Deferiprone Alone or in Combination With Desferrioxamine in Iron Overloaded Transfusion-dependent Patients
Status: COMPLETED
Conditions: Hemochromatosis
Interventions: DRUG: Deferiprone (L1)|DRUG: Deferiprone (L1)|DRUG: Desferrioxamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of the "Ten Steps for Healthy Feeding of Children Younger Than Two Years" in Health Centers
Status: COMPLETED
Conditions: Feeding and Eating Disorders of Childhood
Interventions: BEHAVIORAL: Dietary Advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intermittent Fasting Among Overweight and Obese Civil Servants in Malaysia.
Status: COMPLETED
Conditions: Intermittent Fasting|Obesity
Interventions: OTHER: Intermittent Fasting|OTHER: Healthy Plate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Objective Diagnosis Method and Efficacy of Repetitive Transcranial Magnetic Stimulation as a Treatment for Tinnitus
Status: UNKNOWN
Conditions: Tinnitus
Interventions: DEVICE: Active rTMS(A)|DEVICE: Active rTMS(B)|DEVICE: Sham condition(C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lymphoseek® as Lymphoid Tissue Targeting Agents in Colon Cancer(CNC)
Status: COMPLETED
Conditions: Colon Cancer|Rectal Cancer
Interventions: DRUG: Lymphoseek and VBD Sln dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: To Evaluate Efficacy and Safety of Parsaclisib and Ruxolitinib in Participants With Myelofibrosis Who Have Suboptimal Response to Ruxolitinib (LIMBER-304)
Status: TERMINATED
Conditions: Myelofibrosis|Primary Myelofibrosis|Post Essential Thrombocythemia Myelofibrosis|Post Polycythemia Vera Myelofibrosis
Interventions: DRUG: parsaclisib|DRUG: ruxolitinib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Online MR-guided Radiotherapy on a 1.5T MR-Linac
Status: RECRUITING
Conditions: Rectal Cancer|Head and Neck Cancer|Liver Cancer|Breast Cancer|Prostate Cancer|Oligometastasis|Esophageal Cancer
Interventions: RADIATION: Radiotherapy on the MR-Linac|DIAGNOSTIC_TEST: Imaging on the MR Linac
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benefit of Wearing an Activity Tracker in Sarcoidosis
Status: COMPLETED
Conditions: Sarcoidosis|Fatigue
Interventions: BEHAVIORAL: Physical Activity using an Activity Tracker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Post Market Clinical Follow-up (PMCF) Study of Clareon Vivity & Clareon PanOptix
Status: RECRUITING
Conditions: Aphakia|Astigmatism|Presbyopia
Interventions: DEVICE: Clareon Vivity IOL - Non Toric|DEVICE: Clareon Vivity IOL - Toric|DEVICE: Clareon PanOptix Trifocal IOL - Non Toric|DEVICE: Clareon PanOptix Trifocal IOL - Toric
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Amiloride Solution and Tobramycin Solution for Inhalation for the Eradication of Burkholderia Dolosa in Patients With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Amiloride Solution for Inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eszopiclone for the Treatment of Posttraumatic Stress Disorder
Status: COMPLETED
Conditions: Posttraumatic Stress Disorders
Interventions: DRUG: Eszopiclone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Follow-up Study of Autologous Adipose-derived Stem Cells (ANTG-ASC) for the Complex Fistula (ANTG-ASC-211)
Status: TERMINATED
Conditions: Perianal Fistula|Primary; Complex
Interventions: BIOLOGICAL: Autologous adipose derived stem cells(low dose group)|BIOLOGICAL: Autologous adipose derived stem cells(high dose group)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multi-Center Study of the Effects of Simvastatin on Hepatic Decompensation and Death in Subjects Presenting With High-Risk Compensated Cirrhosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Cirrhosis
Interventions: DRUG: Placebo Oral Tablet|DRUG: Simvastatin 40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: tDCS and Cognitive Training in Active Duty Service Members With Mild TBI: A Pilot Study
Status: RECRUITING
Conditions: Brain Concussion|Brain Trauma|Attention Concentration Difficulty|Brain Injuries|Brain Injuries, Traumatic|Neurocognitive Dysfunction|Attention Impaired|Memory Impairment|Mild Traumatic Brain Injury|Mild Cognitive Impairment
Interventions: COMBINATION_PRODUCT: active tDCS and cognitive training intervention|COMBINATION_PRODUCT: sham tDCS and cognitive training intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Megestrol Acetate Against Cancer-related Critical Body Weight Loss in Patients With H&N Cancer Who Receiving CCRT
Status: UNKNOWN
Conditions: Head and Neck Cancer
Interventions: DRUG: Megestrol acetate (MA) 400 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pharmacokinetics Study of Intravenous Ascorbic Acid
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Ascor L 500® (Ascorbic Acid Injection, USP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Presence of a Hangover Effect in Healthy Adults After Administration of Songha® Night Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Songha® Night|DRUG: Oxazepam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: RIBS V (Restenosis Intra-stent of Bare Metal Stents: Paclitaxel-eluting Balloon vs Everolimus-eluting Stent)
Status: UNKNOWN
Conditions: In-Stent Restenosis
Interventions: DEVICE: Coronary angioplasty using the paclitaxel-eluting balloon|DEVICE: Coronary angioplasty using the everolimus-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cerebral Bleeding in COVID-19 ARDS Patients on Veno-venous ECMO
Status: UNKNOWN
Conditions: Acute Respiratory Distress Syndrome|Extracorporeal Membrane Oxygenation Complication|Corona Virus Infection
Interventions: OTHER: Incidence of bleeding complications in ARDS patients on veno-venous ECMO
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hyperbaric Oxygen Therapy for Hematopoietic Progenitor Cell Collection in Poor Mobilizers
Status: WITHDRAWN
Conditions: Bone Marrow Transplantation|Hematopoietic Stem Cells|Multiple Myeloma|Lymphoma
Interventions: DRUG: Neupogen|PROCEDURE: Hyperbaric oxygen therapy|DRUG: Plerixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of Paraffin Bath Therapy and ESWT in Patients With De Quervain Tenosynovitis
Status: COMPLETED
Conditions: De Quervain Disease
Interventions: DEVICE: Paraffin Bath Therapy|DEVICE: Extracorporeal Shock Wave Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Alirocumab(Proprotein Convertase Subtilisin/Kexin type9 Inhibitor) and Rosuvastatin or Rosuvastatin Alone on Lipid Core Plaques in Coronary Artery Disease Evaluated by Near-infrared Spectroscopy Intravascular Ultrasound
Status: UNKNOWN
Conditions: Coronary Artery Disease|Angina Pectoris
Interventions: DRUG: Alirocumab 75 MG/ML [Praluent]+ Rosuvastatin 10mg/daily|DRUG: Rosuvastatin calcium10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remission of ICD by Switching Dopamine Agonist to Levodopa/Carbidopa
Status: COMPLETED
Conditions: Impulse Control Disorder
Interventions: DRUG: Levodopa/Carbidopa(200mg/50mg)|DRUG: Dopaminergic Agonists
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Treatment of Genito-urinary Syndrome in Women
Status: NOT_YET_RECRUITING
Conditions: Laser-Induced Scar|Breast Cancer|Endometrial Cancer|Menopause|Vaginal Atrophy|Bladder, Overactive
Interventions: PROCEDURE: Vaginal laser treatment|DEVICE: sham|DEVICE: laser system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neoadjuvant Therapy With Nab-paclitaxel and Cisplatin for Locally Advanced Esophageal Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Nab-paclitaxel and Cisplatin|PROCEDURE: surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dendritic Cell Vaccination in Patients With Advanced Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: BIOLOGICAL: Mature dendritic cell (DC) vaccine|DRUG: Cyclophosphamide 300mg/m^2|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: This is a Trial of MG1-E6E7 With Ad-E6E7 and Atezolizumab in Patients With HPV Associated Cancers
Status: TERMINATED
Conditions: HPV-Associated Cancers
Interventions: BIOLOGICAL: Ad-E6E7|BIOLOGICAL: MG1-E6E7|BIOLOGICAL: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Estimate the Efficacy of the Trapezium-Metacarpal (TMC) Prosthesis Compared to Suspensionplasty.
Status: RECRUITING
Conditions: First CarpoMetacarpal Osteoartrithis|Basal Thumb Osteoartrithis
Interventions: PROCEDURE: Maïa® TMC Prosthesis (Lépine Groupe)|PROCEDURE: APL Suspensionplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of Memantine in Moderate to Severe Alzheimer's Disease
Status: COMPLETED
Conditions: Dementia of the Alzheimer's Type
Interventions: DRUG: memantine ER|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Study of Different Biological Tests (Multiplate, ROTEM) in a Cohort of Patients Followed for Essential Thrombocytemia (ET)
Status: COMPLETED
Conditions: Thrombocythemia Essential
Interventions: BIOLOGICAL: biological tests of haemostasis at each consultation (Multiplate, ROTEM, VASP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Neokare Safety and Tolerability Assessment in Neonates With GI Problems
Status: RECRUITING
Conditions: NEC|Gastroschisis|Intestinal Perforation|Atresia, Intestinal|Hirschsprung Disease|Exomphalos|Volvulus|Anorectal Malformations|Meconium Ileus|Cows Milk Allergy|Preterm
Interventions: OTHER: NeoKare Breast Milk Fortifier
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MATRIX-002: Trial to Assess Acceptability and Safety of Two Placebo Vaginal Films
Status: RECRUITING
Conditions: Safety|Acceptability|Usability
Interventions: DRUG: Placebo Vaginal Film with Square Corners|DRUG: Placebo Vaginal Film with Rounded Corners
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Immunogenicity of CVD 1902 Oral Attenuated Vaccine to Prevent S. Paratyphi A Infection
Status: COMPLETED
Conditions: Salmonella
Interventions: BIOLOGICAL: CVD 1902, a Salmonella enterica Serovar Paratyphi A live, oral vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Post-traumatic Stress Disorder Treatment Using Transcranial Direct Current Stimulation (tDCS) Enhancement of Trauma-focused Therapy : a Two-arm Randomized Controlled Multicentric Study.
Status: COMPLETED
Conditions: Post-traumatic Stress Disorder
Interventions: DEVICE: tDCS|DEVICE: Placebo tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating the Efficacy and Safety of Oral Vadadustat Once Daily (QD) and Three Times Weekly (TIW) for the Maintenance Treatment of Anemia in Hemodialysis Subjects Converting From Erythropoiesis-Stimulating Agents (ESAs)
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Vadadustat|DRUG: Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT