pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study Comparing the Bioequivalence of Azelastine Hydrochloride and Fluticasone Propionate Nasal Spray (Apotex, Inc.) to That of Dymista™ Nasal Spray (Meda Pharmaceuticals, Inc.) in the Treatment of Seasonal Allergic Rhinitis
Status: UNKNOWN
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Azelastine HCl and Fluticasone Propionate Nasal Spray, 137 µg/50 µg per spray|DRUG: Dymista™ Nasal Spray|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib Study of Stereotactic Body Radiotherapy (SBRT) Plus Sorafenib in Patients With Unresectable Hepatocellular Carcinoma (HCC)
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Sorafenib|RADIATION: Stereotactic radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Tumor Tissue Antigen-sensitized DC-CIK Cells Combined With Chemotherapy for Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Neoplasms|Neoplasms|Digestive System Neoplasms|Esophageal Cancer
Interventions: DRUG: Paclitaxel|BIOLOGICAL: DC-CIK|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Lenalidomide and Dexamethasone With or Without Pembrolizumab (MK-3475) in Participants With Newly Diagnosed Treatment Naive Multiple Myeloma (MK-3475-185/KEYNOTE-185)
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Novel Supplement on Glycemic Variability Measured by Continuous Glucose Monitoring
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Carbohydrate blocking supplement (CBS)|DIETARY_SUPPLEMENT: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: LifeZig Personalized Reminiscence Video With Slideshows and Music for Individuals With Alzheimer's and Dementia
Status: COMPLETED
Conditions: Alzheimer's Disease|Dementia
Interventions: BEHAVIORAL: Lifezig
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sorafenib or Lenvatinib Plus HAIC of 130 mg/m² Oxaliplatin, and 5-fu vs Sorafenib or Lenvatinib Plus HAIC of 85mg/m² Oxaliplatin, and 5-fu for Unresectable Advanced HCC: a Randomised Phase 3 Trial
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: HAIC of 130 mg/m² Oxaliplatin, and 5-fu|DRUG: HAIC of 85 mg/m² Oxaliplatin, and 5-fu|DRUG: TKI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antiviral Clinical Trial for Long Covid-19
Status: NOT_YET_RECRUITING
Conditions: Long Covid
Interventions: DRUG: tenofovir disoproxil/emtricitabine|DRUG: Selzentry|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Wound Infiltration of Liposomal Bupivacaine v Plain Bupivacaine for Post-Op Pain Control in Elective Cesarean Delivery
Status: UNKNOWN
Conditions: Bupivacaine|Pain, Postoperative
Interventions: DRUG: Bupivacaine|DRUG: Liposomal bupivacaine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Double-blind Placebo-controlled Study of the Effect of Xolair (Omalizumab) in Chronic Urticaria Patients
Status: COMPLETED
Conditions: Chronic Urticaria|Chronic Idiopathic Urticaria|Chronic Spontaneous Urticaria
Interventions: DRUG: Omalizumab (Xolair)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Water Intake and Glycemic Response : Preliminary Study
Status: UNKNOWN
Conditions: Healthy
Interventions: OTHER: Glucose Ref - Std|OTHER: Glucose Ref and 450 ml water|OTHER: White Bread with 250 ml water|OTHER: White Bread and 700 ml water|OTHER: White Bread with 125 ml water (twice)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Humoral and Cellular İmmune Response to SARS-CoV-2 mRNA BNT162b2 Vaccine in Children With Chronic Kidney Diseases
Status: COMPLETED
Conditions: Chronic Kidney Disease 5D|Chronic Kidney Disease 5T
Interventions: BIOLOGICAL: SARS-CoV-2 mRNA BNT162b2 vaccine (Pfizer-BioNTech®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: TArgeting Type 1 Diabetes Using POLyamines (TADPOL)
Status: RECRUITING
Conditions: Type 1 Diabetes
Interventions: DRUG: DFMO|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bacterial and Antimicrobial Susceptibility Profile and the Prevalence of Different Sites of Infection(BASPP)
Status: COMPLETED
Conditions: Infectious Diseases in Pneumonia,Nephropyelitis,Angiocholitis or Others|Positive Bacterial Cultures Results of the Medical Records
Interventions: OTHER: descriptive study which reviewed the data of patients hospitalized with positive bacterial cultures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pazopanib Hydrochloride in Treating Patients With Advanced Neuroendocrine Cancer
Status: COMPLETED
Conditions: Gastrin-Producing Neuroendocrine Tumor|Lung Carcinoid Tumor|Metastatic Digestive System Neuroendocrine Tumor G1|Multiple Endocrine Neoplasia Type 1|Pancreatic Glucagonoma|Pancreatic Insulinoma|Pancreatic Polypeptide Tumor|Recurrent Digestive System Neuroendocrine Tumor G1|Recurrent Pancreatic Neuroendocrine Carcinoma|Regional Digestive System Neuroendocrine Tumor G1|Somatostatin-Producing Neuroendocrine Tumor
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Pazopanib Hydrochloride|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Single-Use of Peroxyl Mouthwash for Reducing Bacteria Saliva and Bioaerosol Contamination Phase 2
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Peroxyl Oral Product|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Peripheral Muscle Training and Inspiratory Muscle Training in Geriatric Individuals
Status: NOT_YET_RECRUITING
Conditions: Muscle Strength
Interventions: OTHER: Peripheral Muscle Training and step aerobics training|OTHER: Inspiratory Muscle Training and step aerobics training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of IPX159 in Restless Legs Syndrome (RLS)
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: IPX159|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Optimal Dose of Indomethacin Suppository for Preventing Post-ERCP Pancreatitis
Status: COMPLETED
Conditions: Pancreatitis|Cholangiopancreatography, Endoscopic Retrograde|Indomethacin
Interventions: DRUG: Indomethacin Suppository
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Effects of 12 Weeks Supplementation With a B-vitamin and Herbal Supplement on Neurocognitive Function and Mood
Status: COMPLETED
Conditions: Neurocognitive Function|Mood
Interventions: DIETARY_SUPPLEMENT: Swisse Ultiboost Memory + Focus|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Correlation of LONGterm Wrist ACTigraphy Recorded Physical Performance & 6-minute Walk Distance in Patients With Pulmonary Arterial Hypertension
Status: WITHDRAWN
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Endothelin receptor antagonist therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Efficacy and Safety of TMC207 in Patients With Pulmonary Infection With Multi-drug Resistant Mycobacterium Tuberculosis
Status: WITHDRAWN
Conditions: Multi-drug Resistant Tuberculosis
Interventions: DRUG: Arm A Double-blind Phase: TMC207|DRUG: Arm B Double-blind Phase: Placebo|DRUG: Treatment Failure During Double-blind Phase: TMC207|DRUG: Treatment Failure During Follow-up Phase: TMC207
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Esomeplazole (D961H) in Japanese Paediatric Patients With Reflux Esophagitis, Gastric Ulcer or Duodenal Ulcer
Status: COMPLETED
Conditions: Reflux Esophagitis|Gastric Ulcer|Duodenal Ulcer
Interventions: DRUG: D961H capsule 10mg|DRUG: D961H sachet 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pressure-wire Guided PTCA: Drug Eluting Stent Versus Drug Eluting Balloon (WinDEB Study)
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: Angioplasty performed via Paclitaxel Eluting Balloon catheter|DEVICE: Angioplasty via DES
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose:
Clinical trial: Pain Management in Head and Neck Surgery Patients
Status: WITHDRAWN
Conditions: Pain Management
Interventions: DRUG: Oxycodone|DRUG: Acetaminophen|DRUG: Gabapentin|DRUG: Celecoxib|DRUG: Hydrocodone-Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Antiplatelet Efficacy of Aspirin Combined With Clopidogrel and Aspirin Combined With Half-dose Ticagrelor in Patients With Unruptured Intracranial Aneurysms With Normal CYP2C19 Metabolizer Phenotype
Status: NOT_YET_RECRUITING
Conditions: Intracranial Aneurysms|Antiplatelet Drugs
Interventions: DRUG: Aspirin combined with clopidogrel|DRUG: Aspirin combined with half-dose ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nanodiamond Modified Gutta Percha (NDGP) Composite for Non-surgical Root Canal Therapy (RCT) Filler Material
Status: COMPLETED
Conditions: Dental Pulp Diseases|Dental Pulp Necrosis|Nerve Root Pain Nec
Interventions: DEVICE: Nanodiamond reinforced Gutta Percha|DEVICE: Gutta Percha
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Protection After Transplant Pilot Study
Status: COMPLETED
Conditions: Kidney Transplant Recipients
Interventions: BIOLOGICAL: BNT162b2 vaccine (Pfizer/BioNTech)|BIOLOGICAL: mRNA-1273 vaccine (Moderna)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: What is the Active Ingredient in Personalized Feedback Interventions for Problem Drinkers? A Randomized Controlled Trial
Status: COMPLETED
Conditions: Problem Drinking
Interventions: BEHAVIORAL: Check Your Drinking (CYD) personalized feedback intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: AZD2171 in Treating Patients With Recurrent Small Cell Lung Cancer
Status: COMPLETED
Conditions: Recurrent Non-small Cell Lung Cancer
Interventions: DRUG: cediranib maleate|OTHER: laboratory biomarker analysis|OTHER: pharmacogenomic studies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DO-HEALTH / Vitamin D3 - Omega3 - Home Exercise - Healthy Ageing and Longevity Trial
Status: COMPLETED
Conditions: Improve Healthy Ageing in Seniors; Prevent Disease at Older Age
Interventions: DRUG: Vitamin D3|DRUG: Omega 3 fatty acids|PROCEDURE: Strength Home Exercise|PROCEDURE: Flexibility Home Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transforaminal Lumbar Interbody Fusion (TLIF)
Status: RECRUITING
Conditions: Degenerative Disease of the Lumbosacral Spine
Interventions: DEVICE: Infuse™ Bone Graft (Infuse™)|DEVICE: Intervertebral body fusion device and Medtronic posterior Fixation Systems
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Internal Radiation Therapy in Treating Patients With Primary Liver Cancer That Cannot Be Removed by Surgery
Status: TERMINATED
Conditions: Liver Cancer
Interventions: PROCEDURE: quality-of-life assessment|RADIATION: yttrium Y 90 resin microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calmer Life: Treating Worry Among Older Adults In Underserved, Low-income, Minority Communities
Status: COMPLETED
Conditions: Anxiety
Interventions: BEHAVIORAL: Cognitive behavior treatment|BEHAVIORAL: Information and referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Iron Status Through Consumption Of Iron Fortified Cowpea: An Intervention Study
Status: COMPLETED
Conditions: Anemia|Low Iron Stores
Interventions: DIETARY_SUPPLEMENT: Cowpea fortified with NaFeEDTA, in form of Toubani.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Temporary Hydrostatic Splint Therapy and Its Effects on Occlusal Forces
Status: COMPLETED
Conditions: Temporomandibular Joint Disorders
Interventions: DIAGNOSTIC_TEST: T-Scan occlusal recording No. I|DEVICE: Usage of the hydrostatic appliance|DIAGNOSTIC_TEST: T-Scan occlusal recording No. II
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dexpramipexole Japanese PK Study
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Single dose reduced|DRUG: Single dose standard|DRUG: Multiple Dose|DRUG: Multiple Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Minimalist Shoes Walking for Children
Status: UNKNOWN
Conditions: Muscle Strength|Ultrasonography|Child, Preschool
Interventions: BEHAVIORAL: in-school walking training with minimalist shoes|BEHAVIORAL: in-school walking training with protective shoes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenomic Study on Anti-VEGF Medicine in Treatment of Macular Neovascular Diseases
Status: UNKNOWN
Conditions: Age-Related Macular Degeneration|Polypoidal Choroidal Vasculopathy|Pathological Myopia|Conbercept|Pharmacogenomic
Interventions: DRUG: Intravitreal injection of conbercept
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Contrast-enhanced Ultrasound (CE-US) and Magnetic Resonance Imaging (MRI): Evaluating Plaque Neovascularisation
Status: COMPLETED
Conditions: Carotid Artery Stenosis|Atherosclerosis
Interventions: DRUG: sulphur hexafluoride, gadopentate dimeglumine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Adaptive Stereotactic Body Radiation Therapy to the Prostate and Pelvic Nodes With Simultaneous Integrated Boost to the MR-detected Nodule for Patients With High-risk and Unfavorable Intermediate-risk Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer|Cancer of the Prostate
Interventions: DEVICE: Ethos Varian treatment system|RADIATION: Adaptive stereotactic body radiotherapy|DRUG: Androgen deprivation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cell Therapy for SARS-CoV-2-related Acute Respiratory Distress Syndrome
Status: UNKNOWN
Conditions: Covid-19
Interventions: BIOLOGICAL: Cell therapy protocol 1|BIOLOGICAL: Cell therapy protocol 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Body Mass Index on the Dose of Intrathecal Hyperbaric Bupivacaine for Elective Cesarean Section
Status: COMPLETED
Conditions: Pain|Obesity
Interventions: DRUG: bupivacaine 0.75% with fentanyl and morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mechanical-chemical Gingival Therapy in Diabetics and/or Obese
Status: COMPLETED
Conditions: Gingivitis|Diabetes|Obesity
Interventions: OTHER: Ultrason Essential oils rinse|OTHER: Ultrason Placebo rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Ischemic Lesions in Scleroderma Treated With Oral Treprostinil Diethanolamine
Status: COMPLETED
Conditions: Systemic Sclerosis|Scleroderma
Interventions: DRUG: treprostinil diethanolamine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise for Tumor Suppressive Impact in Black Men With Prostate Cancer on Active Surveillance: The REMOVE Trial
Status: RECRUITING
Conditions: Prostate Cancer|Prostatic Neoplasms
Interventions: BEHAVIORAL: High-Intensity Interval Training Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PROSpect: Prone and Oscillation Pediatric Clinical Trial
Status: ENROLLING_BY_INVITATION
Conditions: Acute Respiratory Distress Syndrome in Children
Interventions: OTHER: Either supine or prone positioning and either CMV or HFOV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy and Safety of Immune Globulin Intravenous (Human) Flebogamma® 5% DIF in Patients With Post-polio Syndrome
Status: TERMINATED
Conditions: Post-polio Syndrome
Interventions: BIOLOGICAL: Flebogamma 5% DIF|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spermatogonial Stem Cells in Azoospermic Patients: a Comparison Between Obstructive and Non-obstructive Azoospermia
Status: UNKNOWN
Conditions: Male Infertility
Interventions: OTHER: Biospecimen staining|OTHER: Biospecimen staining
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate Adverse Events and Movement of Lemzoparlimab in Body When Used Intravenously (IV) With Azacitidine Subcutaneously or IV and Venetoclax Orally in Participants With Acute Myeloid Leukemia and With Azacitidine With or Without Venetoclax in Participants With Myelodysplastic Syndrome
Status: TERMINATED
Conditions: Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome (MDS)
Interventions: DRUG: Lemzoparlimab|DRUG: Azacitidine|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Regulatory Tools on Work Environment and Employee Health
Status: COMPLETED
Conditions: Occupational Health|Sick Leave|Occupational Exposure
Interventions: BEHAVIORAL: Inspection visits|BEHAVIORAL: Guidance workshops|BEHAVIORAL: Online risk assessment tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Peginterferon Treatment Study for Inactive Chronic Hepatitis B Patients
Status: RECRUITING
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Peginterferon Alfa-2B|DRUG: Nucleoside Analogs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Psychosocial Intervention for Patients With Colorectal Cancer and Their Family Caregivers
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: OTHER: An interactive Colorectal Cancer self-Management enhancement smartphone-based psychosocial intervention programme (iCanManage)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Sitagliptin in Impaired Glucose Tolerance
Status: UNKNOWN
Conditions: Impaired Glucose Tolerance
Interventions: DRUG: Sitagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Bevacizumab in Treating Patients With Stage IV Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Floxuridine|DRUG: Irinotecan|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 4% Chlorhexidine Gluconate Daily Bathing for Prevention of Hospital-acquired Infections in Intensive Care Settings
Status: COMPLETED
Conditions: Hospital Infection
Interventions: DRUG: 4% chlorhexidine gluconate soap-like solution|OTHER: standard soap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, and Pharmacokinetics of PA9159 Nasal Spray in Healthy Adult Subjects
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: PA9159 nasal spray solution, 10 μg one day treatment|DRUG: PA9159 nasal spray solution, 20 μg one day treatment|DRUG: PA9159 nasal spray solution, 40 μg one day treatment|DRUG: PA9159 nasal spray solution, 80 μg one day treatment|DRUG: PA9159 nasal spray solution, 20 μg 7-day treatment|DRUG: PA9159 nasal spray solution, 40 μg 7-day treatment|DRUG: Placebo, the same intranasal spray solution without PA9159 active ingredient
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyperglycemia and the Extra-pancreatic Effect of Incretins
Status: COMPLETED
Conditions: Extra-pancreatic Incretin Effect|Glucose Effectiveness
Interventions: BIOLOGICAL: Saline|BIOLOGICAL: GIP|BIOLOGICAL: GLP-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interest of Hypnosis When Setting up Non-invasive Ventilation in a Conscious Patient With COPD and/or Obesity With a BMI Greater Than 30, Suffering Fromacute Respiratory Distress in Adult Intensive Care
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease (COPD)|Obesity With a BMI Greater Than 30|Acute Respiratory Distress in Adult Intensive Care
Interventions: OTHER: Hypnosis + NIV|OTHER: NIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Safety, Tolerability, Pharmacokinetics(PK) of SR419 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: SR419|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Spinal Stimulation as an Adjuvant Therapy for Trunk Control After Pediatric SCI
Status: ENROLLING_BY_INVITATION
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Biostim-5/Neostim transcutaneous spinal stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Methods of Teaching Self-management Strategies to Patients With Symptomatic Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Educational handout|OTHER: Verbal script|DRUG: Hyaluronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Ivermectin, Aspirin, Dexamethasone and Enoxaparin as Treatment of Covid 19
Status: COMPLETED
Conditions: Severe Acute Respiratory Syndrome|Ventilation Pneumonitis
Interventions: DRUG: Ivermectin 5 MG/ML oral solution, Aspirin 250 mg tablets|OTHER: Ivermectin 5 mg/mL oral solution, Dexamethasone 4-mg injection, Aspirin 250 mg tablets|OTHER: Ivermectin 5 MG/ML oral solution, Dexamethasone 4-mg injection, Enoxaparin injection. Inpatient treatment with mechanical ventilation in ICU.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Quality of Life After Transanal Total Mesorectal Excision Compared to Traditional Total Mesorectal Excision
Status: NOT_YET_RECRUITING
Conditions: Rectal Cancer|Quality of Life|Functional Outcome|Surgery
Interventions: PROCEDURE: Transanal total mesorectal excision
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Real-world Study of HER2-overexpressed Advanced Solid Tumors After Progression of First-line Standard Therapy
Status: NOT_YET_RECRUITING
Conditions: HER2|Advanced Gastric Cancer|Advanced Gastroesophageal Junction Adenocarcinoma|Advanced Solid Tumor
Interventions: DRUG: Disitamab Vedotin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intraestromal Corneal Ring in Mild Keratoconus
Status: COMPLETED
Conditions: Cornea|Eye Diseases|Keratoconus|Ophthalmological Disorder
Interventions: DEVICE: Intraestromal corneal ring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Applicability and Reliability of the Three Meter Backwalk Test in Children With Cerebral Palsy (CP)
Status: COMPLETED
Conditions: Cerebral Palsy|Cerebral Palsy Spastic Diplegia|Hemiplegic Cerebral Palsy|Gait, Hemiplegic|Gait, Spastic
Interventions: OTHER: assessments
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Selinexor and Lenalidomide for Consolidation and Maintenance Treatment in Multiple Myeloma Post-transplant
Status: WITHDRAWN
Conditions: Multiple Myeloma|Myeloma-Associated Amyloidosis
Interventions: DRUG: Selinexor|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Tivozanib Hydrochloride to Sorafenib in Participants With Refractory Advanced Renal Cell Carcinoma (RCC)
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Tivozanib hydrochloride|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Exploratory Study of AR-based Home Rehabilitation Exercise Combined With Wearable Sensor (IMU) in the Elderly
Status: RECRUITING
Conditions: Telerehabilitation|Geriatrics|Exercise
Interventions: DEVICE: OASIS Pro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Assess the Efficacy, Safety and Tolerability of IRL201104 in Adults With Active Eosinophilic Esophagitis
Status: COMPLETED
Conditions: Eosinophilic Esophagitis
Interventions: DRUG: IRL201104|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MIRRAD Versus Plication of Entire Diastasis Trial
Status: NOT_YET_RECRUITING
Conditions: Muscle Diastasis
Interventions: PROCEDURE: MIRRAD|PROCEDURE: Plication of the entire diastasis arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Children With Astrocytomas and Primitive Neuroectodermal Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: MOPP Regimen|DRUG: Leucovorin Calcium|DRUG: Mechlorethamine Hydrochloride|DRUG: Methotrexate|DRUG: Prednisone|DRUG: Procarbazine Hydrochloride|DRUG: Vincristine Sulfate|PROCEDURE: Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Value of PET Quantitative Analysis of Coronary Physiology in Coronary Microvascular Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: PET / CT|Coronary Microvascular Disease
Interventions: DIAGNOSTIC_TEST: 13N-NH3 PET cardiac blood flow perfusion rest and load imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fundoplication in Laparoscopic PEH Repair Based on FLIP
Status: ENROLLING_BY_INVITATION
Conditions: Paraesophageal Hernia
Interventions: PROCEDURE: Laparoscopic paraesophageal hernia repair without fundoplication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zoledronate in Preventing Bone Loss in Postmenopausal Women Who Are Receiving Letrozole for Stage I, Stage II, or Stage IIIA Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Osteoporosis
Interventions: DRUG: letrozole|DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Physiological and Perceptual Effects of Music on Resting Metabolic Rate (RMR)
Status: COMPLETED
Conditions: Metabolism
Interventions: OTHER: No Music|OTHER: Relaxing Classical Music|OTHER: Self-Selected Relaxing Music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study on Efficacy and Safety of CBLB612 for Neutropenia Prophylaxis
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: CBLB612|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Adding Hyaluronidase to Bupivacaine in Ultrasound Guided Supraclavicular Brachial Plexus Block
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Hyaluronidase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: ASIS for Botox in Chronic Migraine
Status: UNKNOWN
Conditions: Chronic Migraine More than15 Days Per Month, and Lasting 4 Hours a Day or Longer.
Interventions: DRUG: Gadolinium|DRUG: Gadolinium|DRUG: Efficacy of Botox intramuscularly at Week 6|DRUG: Efficacy of Botox intramuscularly at Week 12|DRUG: Efficacy of Botox intramuscularly at Week 18|DRUG: Efficacy of Botox intramuscularly at Week 24,|DRUG: Efficacy of Botox intramuscularly at Week 30|DRUG: Efficacy of Botox subdermally at Week 6|DRUG: Efficacy of Botox subdermally at Week 12|DRUG: Efficacy of Botox subdermally at Week 18|DRUG: Efficacy of Botox subdermally at Week 24|DRUG: Efficacy of Botox subdermally at Week 30|DRUG: Adverse Reactions of Botox intramuscularly|DRUG: Adverse Reactions of Botox subdermally
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesia-First Sedation in Trauma Patients
Status: RECRUITING
Conditions: Mechanical Ventilation|Respiratory Failure
Interventions: OTHER: Analgesia First Sedation Strategy for Mechanically Ventilated (MV) Trauma Subjects|OTHER: Protocol Directed Sedation and Daily Sedation Interruption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: aICP Measurement in Patients With Cerebral Artery Infarction / aICP MCA Infarction
Status: SUSPENDED
Conditions: Stroke, Acute
Interventions: DEVICE: Vittamed 205 Non-invasive intracranial pressure (ICP) meter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Adoptive Immunotherapy in Relapsed and Non-resectable Sarcomas After Multimodal Treatment.
Status: WITHDRAWN
Conditions: Sarcoma
Interventions: BIOLOGICAL: Autologous CIK Dose level 1|BIOLOGICAL: Autologous CIK Dose level 2|BIOLOGICAL: Autologous CIK Dose level 3|BIOLOGICAL: Autologous CIK Dose level 4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Oral Hygiene Products in an In Situ Caries Model
Status: COMPLETED
Conditions: Dental Caries
Interventions: DRUG: Fluoride free toothpaste|DRUG: Fluoride toothpaste|DRUG: Fluoride mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treating Sleep Apnea Induced Hypoxemia With Oxygen in Acute Stroke Patients
Status: COMPLETED
Conditions: Stroke, Acute
Interventions: OTHER: Low flow nocturnal oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Combined Strategy to Improve Therapeutic Compliance and Degree of Control Among Patients With Hypercholesterolaemia
Status: UNKNOWN
Conditions: Hypercholesterolemia|Medication Adherence|Primary Health Care
Interventions: DEVICE: "COMBINED STRATEGY"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Telitacicept for Prevention of Flares in SLE Patients
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: Telitacicept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Resilience Enhancement Online Training for Nurses (REsOluTioN) Trial
Status: COMPLETED
Conditions: Resilience
Interventions: OTHER: REsOluTioN (Resilience Enhancement Online Training for Nurses)|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Diagnosing Respiratory Disease in Children Using Cough Sounds 2
Status: COMPLETED
Conditions: Pneumonia|Bronchiolitis|Asthma Exacerbation|Croup|Reactive Airway Disease|Upper Respiratory Disease|Viral Lower Respiratory Tract Infections|Lower Respiratory Disease
Interventions: DEVICE: Recordings of Infants and Children's Cough Sounds
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hypovitaminosis C Prevalence and Risk Factors in an Acute Geriatric Unit
Status: COMPLETED
Conditions: Deficiency, Vitamin C
Interventions: DIAGNOSTIC_TEST: Plasmatic Vitamin C concentrations (known as ascorbemia) on a single blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy Study of a Topical Minocycline Foam in Patients With Papulopustular Rosacea
Status: COMPLETED
Conditions: Rosacea|Papulopustular Rosacea
Interventions: DRUG: FMX-103 1.5%|DRUG: FMX-103 3%|DRUG: Vehicle foam (0%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Potential Drug-drug Interaction of Volasertib With Itraconazole in Patients With Various Tumours
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: volasertib|DRUG: itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intrathorathic Oscillations on Pulmonary Functions in Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: PROCEDURE: Quake device training|PROCEDURE: Traditional chest physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non Invasive Ventilation as Airway Clearance in Patients With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DEVICE: Bilevel|DEVICE: PEP mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Therapies and Anti-HIV Therapy Withdrawal in Controlling Viral Load
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: ALVAC(2)120(B,MN)GNP (vCP1452)|DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Aspirin Resistance in Ischemic Stroke Patients at Assiut University Hospital
Status: NOT_YET_RECRUITING
Conditions: Ischemic Stroke
Interventions: DRUG: Acetyl Salicylate|DIAGNOSTIC_TEST: Optical Platelet Aggregation test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Scalability of a Home Health Navigator Program to Reduce Arsenic, Nitrate, and Lead in Private Well Water
Status: RECRUITING
Conditions: Pollution; Exposure
Interventions: BEHAVIORAL: Community health worker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of B. Braun Peripheral Advantage Program on Complications, Indwell Time and First Stick Success of PIVC Therapy
Status: TERMINATED
Conditions: Complications Associated With Device
Interventions: DEVICE: B. Braun Peripheral Advantage (PA) Program|DEVICE: Hospital Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Calibrating Cardiac Output Measurement of Electrical Cardiometry With Transthoracic Echocardiography
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: OTHER: passive leg raising test|PROCEDURE: right heart catheterisation|OTHER: TTE vs. EC + calibration group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Tenofovir and Emtricitabine in ARV-naive Patients With HIV/HBV Co-infection
Status: COMPLETED
Conditions: Hepatitis B Virus|HIV Infections
Interventions: DRUG: Emtricitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of a Stress Device for the Knee
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: RADIATION: Clinician Valgus|RADIATION: Clinician Varus|RADIATION: Device Valgus - 0 Newton|RADIATION: Device Valgus - 10 Newton|RADIATION: Device Valgus - 20 Newton|RADIATION: Device Valgus - 30 Newton|RADIATION: Device Varus - 0 Newton|RADIATION: Device Varus - 10 Newton|RADIATION: Device Varus - 20 Newton|RADIATION: Device Varus - 30 Newton
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Lasofoxifene Versus Fulvestrant in Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced or Metastatic Breast Cancer
Interventions: DRUG: Lasofoxifene|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Toothbrushes in Daily Practice in Patients With Fixed Orthodontic Appliances
Status: RECRUITING
Conditions: Dental Malposition
Interventions: DEVICE: Sonicare Diamond Clean 9000|DEVICE: HydroSonic Pro|DEVICE: Oral-B 123|DEVICE: Curaprox CS 5460
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of a Multicomponent Exercise and Supplementation of BCAA´s in Immunity System Dwelling Elderly
Status: UNKNOWN
Conditions: Frail Elderly Syndrome|Physical Exercise
Interventions: DIETARY_SUPPLEMENT: Branched Chain Aminoacid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Extension Study of Maralixibat in Patients With Progressive Familial Intrahepatic Cholestasis (PFIC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Progressive Familial Intrahepatic Cholestasis (PFIC)
Interventions: DRUG: Maralixibat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extending Long-term Outcomes Through an Adaptive Aftercare Intervention
Status: COMPLETED
Conditions: Cocaine Use Disorder|Contingency Management
Interventions: BEHAVIORAL: prize contingency management on a traditional twice weekly schedule for cocaine abstinence|BEHAVIORAL: prize contingency management on a variable interval schedule for cocaine abstinence|BEHAVIORAL: standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-blind Randomized Controlled Trial Comparing Suvorexant 20 mg to Placebo for Treatment of Insomnia in Cancer Survivors
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Insomnia
Interventions: DRUG: Suvorexant Tablets|OTHER: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Promoting Sleep and Healthy Aging Research Study (PRO-SHARE)
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Sleep Education Therapy|BEHAVIORAL: Cognitve Behavioral Therapy for Insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Different Activation Protocols of Hycon Device and Vibration Stimulation on Canine Teeth Distalization
Status: UNKNOWN
Conditions: Tooth Migration
Interventions: DEVICE: Hycon device(Routine protocol)|DEVICE: Hycon device(Modified protocol)|DEVICE: Hycon device(Routine protocol) and Vibration(Acceledent)|DEVICE: Hycon device(Modified protocol) and Vibration(Acceledent)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Effectiveness of Embrace Wetbond and Clinpro as Pits and Fissure Sealants in Young Permanent Molars
Status: UNKNOWN
Conditions: Caries
Interventions: OTHER: Embrace Wetbond|OTHER: Clinpro sealant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Fermented Brown Seaweed Intake on Glucose Metabolism and Gut Health
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Subjects
Interventions: DIETARY_SUPPLEMENT: Baobab spread mixed with fermented brown seaweed|DIETARY_SUPPLEMENT: Baobab spread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Analgesic Efficacy of Ultrasound Guided Quadratus Lumborum Block During ESWL
Status: COMPLETED
Conditions: Pain, Acute
Interventions: DRUG: Bupivacaine|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diclofenac Patch for the Treatment of Acute Pain Due to Mild to Moderate Wrist Sprain, Strain or Contusion
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: Diclofenac Sodium Patch|DRUG: Matching Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT