pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety, Pharmacokinetics and Preliminary Anti-Tumor Activity of Intravenous TKM-080301 in Subjects With Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Hepatoma|Liver Cancer, Adult|Liver Cell Carcinoma, Adult
Interventions: DRUG: TKM-080301
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerability of Goat Milk Protein in Eosinophilic Esophagitis Patients With Cow Milk Protein Trigger
Status: RECRUITING
Conditions: Eosinophilic Esophagitis
Interventions: OTHER: Goat milk diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Formaderm (Hyaluronic Acid) for Facial Soft Tissue Augmentation
Status: COMPLETED
Conditions: Dermal Filler
Interventions: DEVICE: Formaderm Dermal Filler Injection|DEVICE: "Q-MED" RESTYLANE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Metformin to Prevent Late Miscarriage and Preterm Delivery in Women With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Pregnancy|Polycystic Ovary Syndrome
Interventions: DRUG: Metformin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Eradication of Malignant Carcinoma in the Breast Tissue
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DIETARY_SUPPLEMENT: Acetogenins|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Linagliptin's Effect on CD34+ Stem Cells
Status: COMPLETED
Conditions: Type 2 Diabetes|Impaired Renal Function
Interventions: DRUG: Linagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study to Evaluate the Safety and Efficacy of PT003, PT001, and PT005 in Subjects With Moderate to Very Severe COPD, With Spiriva® Handihaler® (PINNACLE 3)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: GFF MDI (PT 003)|DRUG: GP MDI (PT001)|DRUG: FF MDI (PT005)|DRUG: Open-label tiotropium bromide inhalation (Spiriva® Handihaler®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Docosahexaenoic Acid (DHA) for Women With Breast Cancer in the Neoadjuvant Setting
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DIETARY_SUPPLEMENT: Docosahexaenoic acid (DHA)|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Soy, Bone and Health in College Females
Status: COMPLETED
Conditions: Osteoporosis|Obesity
Interventions: DIETARY_SUPPLEMENT: Soy Protein Dietary Supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Rifaximin in Patients With Papulopustular Rosacea and Positive Lactulose Breath Test
Status: UNKNOWN
Conditions: Papulopustular Rosacea
Interventions: DRUG: Rifaximin delayed release 400 mg tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Use of Misoprostol to Decrease Bleeding During a Myomectomy
Status: COMPLETED
Conditions: Hemorrhage
Interventions: DRUG: Misoprostol + vasopressin|DRUG: Vasopressin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Effect of Rifampicin on the Pharmacokinetics of SHR6390 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: SHR6390 tablet single oral dose of SHR6390 or co-administered with rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Efficacy and Safety of Early Rehabilitation in Large Vessel Occlusion Patients After Intra-arterial Thrombectomy: A Prospective Randomized Controlled Trial
Status: RECRUITING
Conditions: Intra-arterial Thrombectomy
Interventions: OTHER: exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lumbar Manipulation and Exercise for the Treatment of Acute Low Back Pain in Adolescents
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Lumbar Manipulation|OTHER: Sham Manipulation|OTHER: Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Consequences of Obstructive Sleep Apnea on Respiratory Function Following Weight-loss Surgery
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Obesity
Interventions: PROCEDURE: CPAP followed by atmospheric pressure|PROCEDURE: Atmospheric pressure followed by CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Surgical Timing on the Neurodevelopmental Prognosis of Newborns With Complex Congenital Heart Disease
Status: RECRUITING
Conditions: Complex Congenital Heart Disease
Interventions: PROCEDURE: Peri-operative neurological monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pulmonary Rehabilitation in Patients Before Lung Transplantation (LTx)
Status: COMPLETED
Conditions: COPD|Pre-Lung-Transplantation|Hypercapnia|Respiratory Insufficiency
Interventions: OTHER: continuous endurance training|OTHER: interval training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial for Registration of HPV Nucleic Acid Genotyping Assay Kit
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Cancer
Interventions: DIAGNOSTIC_TEST: HPV Genotyping Nucleic Acid Assay Kit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: NC Works4Health: Reducing Chronic Disease Risks in Socioeconomically Disadvantaged, Unemployed Populations
Status: RECRUITING
Conditions: Diabetes|Chronic Disease|Psychological Distress
Interventions: BEHAVIORAL: Immediate Chronic Disease Prevention Program (CDPP)|BEHAVIORAL: Workplace Equity, Job and Health Supports Employer Intervention|BEHAVIORAL: Delayed, attenuated Chronic Disease Prevention Program (CDPP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Randomized, Double-Blind, Placebo-Controlled Trial, Followed by Single-Arm Treatment of PRO 140
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: PRO 140|DRUG: Placebo|DRUG: Optimized Background Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endovascular Acute Stroke Intervention - Tandem OCclusion Trial
Status: RECRUITING
Conditions: Stroke, Acute|Carotid Stenosis|Carotid Artery Diseases
Interventions: DEVICE: Carotid artery stenting|DRUG: Antiplatelet Agents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brief Anxiety Sensitivity Treatment for Obsessive Compulsive Symptoms
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder and Symptoms
Interventions: BEHAVIORAL: Cognitive Anxiety Sensitivity Treatment|BEHAVIORAL: Physical Health Education Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Chemotherapy to Treat Ovarian Cancer Recurrence by Prolonging the Platinum Free Interval
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: stealth liposomal doxorubicin|DRUG: carboplatin|DRUG: paclitaxel|DRUG: Topotecan|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Mesenchymal Stem Cell Transplantation in Advanced Glaucoma.
Status: COMPLETED
Conditions: Retinal Degeneration|Primary Open-angle Glaucoma
Interventions: PROCEDURE: Intravitreal transplantation of mesenchymal stem cell|BIOLOGICAL: Culture and isolation of autologous bone-marrow mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Dideoxycytidine Plus Zidovudine in the Treatment of AIDS or Advanced AIDS Related Complex (ARC)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zidovudine|DRUG: Zalcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Window to Hope-Evaluating a Psychological Treatment for Hopelessness Among Veterans With Traumatic Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury|Hopelessness|Suicide
Interventions: OTHER: Window to Hope|OTHER: Waitlist Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise Interventions for Improving Health in Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer Female
Interventions: BEHAVIORAL: Exercise intervention|BEHAVIORAL: Polar A380 wristwatch physical activity tracker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: FT819 in Moderate to Severe Active Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: FT819|DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Plantarum PS128 in Patients With Major Depressive Disorder and High Level of Inflammation
Status: UNKNOWN
Conditions: Major Depressive Disorder|Inflammation|Probiotics
Interventions: DIETARY_SUPPLEMENT: Lactobacillus plantarum PS128
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cranial Radiotherapy Plus Chemoimmunotherapy in Untreated Driver-mutation Negative NSCLC With Active Brain Metastasis
Status: RECRUITING
Conditions: NSCLC Stage IV
Interventions: DRUG: PD-1/PD-L1 inhibitor plus chemotherapy|RADIATION: SRT/WBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of the Outcomes of 2 Surgical Procedures for Safe Type of Chronic Otitis Media
Status: UNKNOWN
Conditions: Chronic Otitis Media|Tubotympanic Disease
Interventions: PROCEDURE: mastoidotympanoplasty and tympanoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of CNT-01 in Patients With Idiopathic TGCV
Status: COMPLETED
Conditions: Idiopathic Triglyceride Deposit Cardiomyovasculopathy
Interventions: DRUG: CNT-01 500 mg capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of the Safety and Efficacy of Carvedilol in Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Carvedilol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adversity, Brain and Opioid Use Study
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder|Healthy
Interventions: OTHER: Magnetic Resonance Imaging (MRI)|BEHAVIORAL: Computer Tasks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Role of Omega-3 Polyunsaturated Fatty Acid in the Management of Major Depressive Disorder.
Status: COMPLETED
Conditions: Role of Omega-3 Polyunsaturated Fatty Acid in the Management of Major Depressive Disorder: A Randomized Controlled Trial
Interventions: DIETARY_SUPPLEMENT: Omega-3 capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Single Arm Trial of Menstrual Cups Among Economically Vulnerable Women to Reduce Bacterial Vaginosis and STIs
Status: ACTIVE_NOT_RECRUITING
Conditions: Bacterial Vaginosis|Vaginal Microbiome|Chlamydia Trachomatis Infection|Neisseria Gonorrheae Infection|Trichomonas Vaginitis
Interventions: DEVICE: Menstrual Cup
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans Syndrome
Status: COMPLETED
Conditions: Constrictive Bronchiolitis|Bronchiolitis Obliterans|Graft vs Host Disease|Bronchiolitis, Exudative|Bronchiolitis, Proliferative
Interventions: DRUG: Cyclosporine Inhalation Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Dose Azithromycin to Prevent Cholera in Children
Status: RECRUITING
Conditions: Cholera
Interventions: DRUG: Azithromycin|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Toxicogenomic and Immunocytotoxic Effects of Propofol and Isoflurane Anesthetics in Patients Undergoing Elective Surgery
Status: COMPLETED
Conditions: Patients in Good Health|Types of General Anesthesia|DNA Damage
Interventions: DRUG: Comparison of two anesthetic drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Music and Comedy Application on Pain and Kinesyophobia in Patients With TKA
Status: COMPLETED
Conditions: Arthroplasty Complications|Kinesiophobia
Interventions: BEHAVIORAL: Watching comedy movie|BEHAVIORAL: listening to music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial of Treatments to Assess the Effects on Outcome of Adults With AML and MDS Undergoing Allogeneic SCT
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukaemia|High-risk Myelodysplastic Syndrome
Interventions: DRUG: Vyxeos|DRUG: Fludarabine|DRUG: Busulphan|DRUG: Thiotepa|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiological Study of the Human CYP3A Activity (PiSA)
Status: COMPLETED
Conditions: Cytochrome P450 CYP3A Enzyme Deficiency
Interventions: DRUG: AB (Midazolam OD formulation/Dormicum)|DRUG: BA (Dormicum/Midazolam OD formulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rucaparib and Nivolumab in Patients With Prostate or Endometrial Cancer
Status: TERMINATED
Conditions: Prostate Cancer|Endometrial Cancer
Interventions: DRUG: Rucaparib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Pharmacokinetics, Safety, and Tolerability of Balovaptan in Children With Autism Spectrum Disorder
Status: TERMINATED
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Balovaptan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Tolerability and Pharmacokinetics of CKD-348(6)
Status: COMPLETED
Conditions: Hypertension|Dyslipidemias
Interventions: DRUG: CKD-348(6)|DRUG: CKD-828, D097, D337
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Polyphenol-rich Cocoa Products on Cognitive Function
Status: COMPLETED
Conditions: Healthy Ageing
Interventions: DIETARY_SUPPLEMENT: polyphenol rich chocolate bar|DIETARY_SUPPLEMENT: polyphenol rich cocoa powder|DIETARY_SUPPLEMENT: low polyphenol content chocolate bar|DIETARY_SUPPLEMENT: low polyphenol content cocoa powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Combined PECS II and Transeversus Thoracic Plane Blocks Vs Serratus Anterior Plane Block in Modified Radical Mastectomy
Status: COMPLETED
Conditions: Ultrasound-Guided|Transeversus Thoracic Plane Blocks|Pectoral Nerve (PECS) Block|Serratus Anterior Plane Block|Modified Radical Mastectomy
Interventions: PROCEDURE: Pectoral nerve (PECS) block -transversus thoracic plane (TTP) block|PROCEDURE: Serratus anterior plane (SAP) block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Monitoring Anti-Dementia Drugs by Serum Levels
Status: COMPLETED
Conditions: Dementia|Dementia With Lewy Bodies|Dementia in Parkinsons Disease|Dementia Alzheimers|Alzheimer Disease
Interventions: DRUG: Donepezil|DRUG: Memantine|DIAGNOSTIC_TEST: Measurement of serum level of anti-dementia drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Open-Label, Multiple Ascending Dose Study of DS-3078a, an Oral TORC1/2 Kinase Inhibitor, in Subjects With Advanced Solid Tumors or Lymphomas
Status: COMPLETED
Conditions: Advanced Solid Tumor|Lymphoma
Interventions: DRUG: DS-3078a
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Living With Statins - Interventional Exercise Study
Status: UNKNOWN
Conditions: Cardiovascular Disease|Diabetes Mellitus
Interventions: DRUG: Training+Simvastatin+Q10-placebo|DRUG: Training+Simvastatin-placebo+Q10-placebo|DRUG: Training+Simvastatin+Q10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Testing Responses of Young Adults to Intervention Messages for Promoting Physical Activity Trial
Status: RECRUITING
Conditions: Physical Inactivity|Weight Gain
Interventions: BEHAVIORAL: Education|BEHAVIORAL: Activity tracker|BEHAVIORAL: Text messaging (random timing and selection)|BEHAVIORAL: Text messaging (precision dosing)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Comprehensive Tertiary Interventions on Incidence and Clinical Outcomes of Birth Defects
Status: ACTIVE_NOT_RECRUITING
Conditions: Birth Defects
Interventions: PROCEDURE: Standard tertiary interventions of birth defects|PROCEDURE: Additional preconception health care|PROCEDURE: Additional health care procedures during and after pregnancy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Myocardial Ischemia Using Standard Single Photon Emission Computed Tomography (SPECT) With Regadenoson and Simultaneous Cardiac Echocardiography
Status: UNKNOWN
Conditions: Myocardial Ischemia
Interventions: DRUG: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Antibiotic Prophylaxis in Patients Undergoing Elective TKA- Multi-center Trial
Status: RECRUITING
Conditions: Arthropathy of Knee|Antibiotic Prophylaxis
Interventions: DRUG: Cefazolin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chidamide+Decitabine Plus Anti-PD-1 Antibody for Patients With R/R cHL Who Are Transplant-ineligible or Refused Transplant.
Status: NOT_YET_RECRUITING
Conditions: Ineligible Or Refused Transplant Patients With Classical Hodgkin Lymphoma
Interventions: DRUG: Chidamide; Decitabine; Anti-PD-1 Antibody|DRUG: Brentuximab Vedotin+ Bendamustine+Anti-PD-1 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Veliparib in Combination With Gemcitabine and Intensity Modulated Radiation Therapy in Patients With Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Veliparib|DRUG: Gemcitabine|RADIATION: Intensity modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [177Lu]-NeoB in Patients With Advanced Solid Tumors and With [68Ga]-NeoB Lesion Uptake
Status: RECRUITING
Conditions: Neoplasms
Interventions: DRUG: [177Lu]-NeoB|DRUG: [68Ga]-NeoB|DRUG: LCZ696
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relapsing Forms of Multiple Sclerosis (RMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (GEMINI 1)
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: Tolebrutinib|DRUG: Teriflunomide HMR1726|DRUG: Placebo to match Tolebrutinib|DRUG: Placebo to match Teriflunomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Investigation of Functional Improvements in the RHEO KNEE Compared to Hydraulic Microprocessor Controlled Knees (MPKs)
Status: COMPLETED
Conditions: Prosthesis User|Amputation
Interventions: DEVICE: RHEO KNEE XC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Symptoms in Chinese Liver Cancer Patients: Network Analysis
Status: TERMINATED
Conditions: Patients With Primary Liver Cancer (PLC) Undergoing Curative Surgical Procedures|Importance of Identifying Core Symptoms for Improving Symptom Management in PLC Patients|Application of Network Analysis as a Crucial Component of Cancer Care
Interventions: OTHER: postoperative symptoms
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant Depression
Status: RECRUITING
Conditions: Treatment-resistant Depression|Major Depressive Disorder
Interventions: DRUG: Midazolam (active placebo)|DRUG: Ketamine and Midazolam (active placebo)|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gene Expression Levels in Predicting Treatment Response in Patients With Stage IV Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Recurrent Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: DRUG: docetaxel|DRUG: pemetrexed disodium|DRUG: gemcitabine hydrochloride|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed and Erlotinib for Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Pemetrexed|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Prospective Cohort Study on the Benefit-risk of Antithrombotic or Anticoagulant Therapy in Patients With Unruptured Intracranial Aneurysms Associated With Ischemic Heart Disease or Ischemic Cerebrovascular Disease
Status: UNKNOWN
Conditions: Intracranial Aneurysm|Natural History|Ischemic Heart Disease|Ischemic Cerebrovascular Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Perioperative Cognitive Function - Dexmedetomidine and Cognitive Reserve
Status: COMPLETED
Conditions: Postoperative Delirium|PD|Postoperative Cognitive Dysfunction|POCD
Interventions: DRUG: Precedex (Dexmedetomidine)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Thromboelastographic Guide for Blood Products in Cirrhotics
Status: COMPLETED
Conditions: Liver Cirrhosis|Coagulation Disorder
Interventions: PROCEDURE: Thromboelastography to guide blood products infusion|PROCEDURE: Standard of care coagulation tests to guide blood products infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Initiation of First-line Antiretroviral Treatment With TENOFOVIR ALAFENAMIDE - EMTRICITABINE - BICTEGRAVIR at the First Clinical Contact in France: Trial IMEA 055 - FAST
Status: UNKNOWN
Conditions: HIV Seropositivity
Interventions: DRUG: Biktarvy arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Speech Treatment for Minimally Verbal Children With ASD and CAS
Status: RECRUITING
Conditions: Developmental Verbal Dyspraxia|Autism Spectrum Disorder
Interventions: BEHAVIORAL: CAS Treatment for Minimally Verbal Children with Autism
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation in Kidney Disease
Status: COMPLETED
Conditions: Renal Dialysis|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol (Vitamin D)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intravenous Dexamethasone on Postoperative Caudal Analgesia in Pediatric Orchiopexy
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Phase Ia/Ib Open-label, Multiple Dose, Study to Determine the Recommended Dose, Evaluate PKs, PDs, Safety, and Activity of Venetoclax in Combination With Oral Decitabine/Cedazuridine (ASTX727) in Pediatric Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML)
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: ASTX727|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Dose-dependent Effects of DMT in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: N,N-Dimethyltryptamine (54 mg)|DRUG: N,N-Dimethyltryptamine (108 mg)|DRUG: N,N-Dimethyltryptamine (162 mg)|DRUG: N,N-Dimethyltryptamine (216 mg)|DRUG: Placebo|DRUG: N,N-Dimethyltryptamine (108 mg) + dose titration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Vildagliptin Compared to Metformin in Elderly Drug Naive Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Vildagliptin 100 mg qd|DRUG: Metformin 1500 mg daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaping Cessation Using the Ottawa Model for Smoking Cessation Among E-Cigarette Users
Status: RECRUITING
Conditions: Tobacco Smoking|Vaping
Interventions: BEHAVIORAL: OMSC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hospital Implementation of a Stroke Protocol for Emergency Evaluation and Disposition
Status: NOT_YET_RECRUITING
Conditions: Stroke, Acute|Ischemic Stroke, Acute|Hemorrhagic Stroke
Interventions: BEHAVIORAL: HI-SPEED Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Artificial Intelligence in EUS for Diagnosing Pancreatic Solid Lesions
Status: COMPLETED
Conditions: Pancreatic Ductal Adenocarcinoma|Pancreatitis, Chronic|Pancreatic Neuroendocrine Tumor|Autoimmune Pancreatitis
Interventions: DIAGNOSTIC_TEST: EUS-AI model
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Between Platelet Rich Plasma and Corticosteroids for the Treatment of Rotator Cuff Tendinopathy
Status: COMPLETED
Conditions: Shoulder Tendinopaty
Interventions: DRUG: Corticosteroid|BIOLOGICAL: Plathet rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antimicrobial Activity of Two Mouthwashes
Status: COMPLETED
Conditions: Periimplantitis|Dental Plaque|Periodontal Diseases|Caries|Oral Surgical Wound Infection
Interventions: DRUG: chlorhexidine|DRUG: Polyhexamethylene biguanide|DRUG: Sterile saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Chamomile Intake on Blood Coagulation Tests in Healthy Volunteers
Status: COMPLETED
Conditions: Coagulation Disorder
Interventions: DIETARY_SUPPLEMENT: Chamomile Tea|DIETARY_SUPPLEMENT: Chamomile Extract Capsule|DIETARY_SUPPLEMENT: Placebo Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Video-Based Game Therapy in Thoracic Hyperkyphosis
Status: RECRUITING
Conditions: Hyperkyphosis|Postural Kyphosis|Exergaming|Muscle Weakness|Muscle Tightness|Posture Disorders in Children
Interventions: OTHER: Videogame-Based Therapy|OTHER: Waiting list
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Minimizing Immunosuppression in Old for Old Kidney Transplantation
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: MMF (Cellcept) and Steroids|DRUG: Tacrolimus (Prograf)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tamsulosin to Prevent Postoperative Urinary Retention in Laparoscopic Inguinal Hernia Repair
Status: TERMINATED
Conditions: Post Operative Urinary Retention
Interventions: DRUG: Tamsulosin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Comparative Study of Knee Systems
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: PROCEDURE: Total Knee Arthroplasty with Custom Cutting Blocks|PROCEDURE: Total Knee Arthroplasty via Computer Assisted Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy of 2LEBV® and 2LXFS® on Asthenia in Patients With an Epstein-Barr Virus Infection
Status: RECRUITING
Conditions: EBV Infection
Interventions: DRUG: 2LEBV® / 2LXFS®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Study for the Reliability and Validity of Incremental Shuttle Walking Test for COPD Patients in Korea
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DIAGNOSTIC_TEST: Shuttle walking test|DIAGNOSTIC_TEST: Exercise stress test|DIAGNOSTIC_TEST: 6 minutes walking test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Optimal Titration Regimen for SBR759 in Lowering Serum Phosphate Levels in Asian Chronic Kidney Disease Patients on Hemodialysis
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: SBR759|DRUG: Sevelamer HCl|DRUG: Sevelamer HCl|DRUG: Sevelamer HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare the Knob-tipped Knife With the Needle Knife in Difficult Biliary Cannulation
Status: UNKNOWN
Conditions: Endoscopic Retrograde Cholangiopancreatography|Bile Duct Diseases
Interventions: PROCEDURE: Precut papillotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Motor Interference Therapy For Traumatic Memories
Status: COMPLETED
Conditions: Trauma, Psychological|Post Traumatic Stress Disorder
Interventions: OTHER: motor interference therapy|OTHER: Relaxation exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Ligelizumab in the Treatment of CSU in Japanese Patients Inadequately Controlled With H1- Antihistamines
Status: COMPLETED
Conditions: Chronic Spontaneous Urticaria
Interventions: BIOLOGICAL: Ligelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Spinal Cord Neuromodulation to Normalize Autonomic Phenotypes
Status: COMPLETED
Conditions: Spinal Cord Injuries|Autonomic Imbalance|Autonomic Dysreflexia|Orthostatic; Hypotension, Neurogenic
Interventions: DIAGNOSTIC_TEST: Tests of sympathetic inhibition|DIAGNOSTIC_TEST: Tests of sympathetic activation|DIAGNOSTIC_TEST: Testing of autonomic dysreflexia|DEVICE: Transcutaneous spinal cord stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparing Morbidity and Mortality Effects of Two Different Strains of BCG
Status: COMPLETED
Conditions: Heterologous Immunity|Infant Morbidity|Infant Mortality|Trained Immunity|Vaccine Reaction|Vaccine Adverse Reaction
Interventions: BIOLOGICAL: BCG-Japan|BIOLOGICAL: BCG-Russia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: EPBONF : Evaluation of the Safety and Effectiveness of a Medical Device Aimed at Guiding Orbito-naso-frontal Band Surgery, for the Treatment of Craniostenoses
Status: NOT_YET_RECRUITING
Conditions: Craniosynostoses
Interventions: DEVICE: BONFIX system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Androgen Deprivation Therapy Plus Abiraterone With or Without Apalutamide for High-Risk Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Goserelin|DRUG: Prednisone|DRUG: Abiraterone|DRUG: Apalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Topiramate for Cocaine Addiction
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: topiramate|BEHAVIORAL: Contingency Reinforcement|DRUG: placebo + NonCR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Motivational Support Program Applied to Adolescents on Sleep Quality and Academic Achievement
Status: NOT_YET_RECRUITING
Conditions: High School 11th Grade Students|Absence of Any Language, Hearing, Mental or Psychological Disability|Turkish Speaking and Understanding|Having a PUKI Index Above 5ı|Absence of Any Chronic Disease|Obtaining Permission From Parents and Students
Interventions: BEHAVIORAL: Motivational Support Program|BEHAVIORAL: Educational support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Association of Type 1 Diabetes Mellitus in Offsprings With Positive Parental History of Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Blood draw for insulin auto-anti body tests*
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TriBEL Registry: National Belgian Registry of Percutaneous Tricuspid Valve Repair Using a Transcatheter Edge-to-edge Repair Technique
Status: NOT_YET_RECRUITING
Conditions: Tricuspid Valve Regurgitation
Interventions: PROCEDURE: Transcatheter edge-to-edge repair (TEER)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Long-term Safety of Protopic in Atopic Eczema
Status: COMPLETED
Conditions: Dermatitis, Atopic|Eczema, Atopic
Interventions: DRUG: Tacrolimus ointment 0.1%
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trans Cutaneous Electrical Acupoint Stimulation Versus TENS On Blood Pressure In Primary Hypertension Patients
Status: RECRUITING
Conditions: Hypertension|Quality of Life
Interventions: DEVICE: Transcutaneous electrical acupoint stimulation|DEVICE: Transcutaneous electrical nerve stimulation (group b):
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lurasidone Low-Dose - High-Dose Study Study
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Lurasidone|DRUG: Lurasidone 80 mg once daily initially rerandomized either to 80 mg or 160 mg at week 2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Takotsubo Cardiomyopathy in Patients Suffering From Acute Non-traumatic Subarachnoid Hemorrhage
Status: COMPLETED
Conditions: Takotsubo Cardiomyopathy|Subarachnoid Hemorrhage
Interventions: PROCEDURE: bleeding, intraventricular and/ or intracerebral hemorrhage.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of tDCS on Maximal Isometric Strength and Endurance Test of Trunk Extensors.
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2a/3 Evaluation of Adding AL3818 to Standard Platinum-Based Chemotherapy in Subjects With Recurrent or Metastatic Endometrial, Ovarian, Fallopian, Primary Peritoneal or Cervical Carcinoma (AL3818-US-002)
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Carcinoma|Ovarian Carcinoma|Fallopian Tube Carcinoma|Primary Peritoneal Carcinoma|Cervical Carcinoma
Interventions: DRUG: AL3818|DRUG: Paclitaxel|DRUG: Pegylated Liposomal Doxorubicin (PLD)|DRUG: Topotecan|DRUG: Topotecan|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: AL3818
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Levalbuterol Plus Ipratropium With Levalbuterol Alone in the Treatment of Acute Asthma Exacerbation
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: ipratropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Trial of a Minimal-invasive Technique Versus Open Arthrodesis in the Treatment of Midfoot Arthritis
Status: RECRUITING
Conditions: Osteoarthritis|Foot|Osteotomy
Interventions: PROCEDURE: reverse distal metatarsal minimal-invasive osteotomy|PROCEDURE: tarsometatarsal fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Probiotic on the Urinary Tract Microbiota of Participants With Recurrent Urinary Tract Infection.
Status: RECRUITING
Conditions: Recurrent Urinary Tract Infection
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Probiotic + placebo|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: In Vivo Preoperative Skin Preparation Persistence Evaluation
Status: COMPLETED
Conditions: Bacterial Recovery of Skin Flora Post-product Application
Interventions: DRUG: 3M CHG/IPA Prep|DRUG: ChloraPrep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating Pembrolizumab +/- Olaparib in TLS Positive Selected Resectable STS Followed by Adjuvant Pembrolizumab
Status: NOT_YET_RECRUITING
Conditions: Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Pembrolizumab and Olaparib|DRUG: Pembrolizumab adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Retrospective Study to Collect the Data From the Patients Who Had the Perimount Heart Valve Replacement Surgery in China During 2001 to 2007
Status: COMPLETED
Conditions: Mitral Valve or Aortic Valve Replacement
Interventions: DEVICE: Perimount 2900/6900 Heart Valve
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vitamin D and Health Outcomes in Preterm Born Population
Status: ACTIVE_NOT_RECRUITING
Conditions: Vitamin D3 Deficiency|Prematurity|Lung Diseases|Heart Rate Variability|Stress Physiology|Bone Diseases, Metabolic
Interventions: DIETARY_SUPPLEMENT: Vitamin D
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of a PROgram of Cardiovascular Nurse interventionS in a VALVular haEmodynamic Unit (PROCESS-VALVE) on Quality Indicators: a Quasi-experimental Ambispective Study
Status: RECRUITING
Conditions: Valvular Heart Disease
Interventions: OTHER: Post-surgical nurse follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety Study of BPX-201 Dendritic Cell Vaccine Plus AP1903 in Metastatic Castrate Resistent Prostate Cancer
Status: COMPLETED
Conditions: Castrate Resistent Prostate Cancer
Interventions: BIOLOGICAL: BPX-201 vaccine plus AP1903
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monitoring Neonatal Resuscitation Trial
Status: COMPLETED
Conditions: Resuscitation|Neonatal Prematurity|Positive-Pressure Respiration
Interventions: DEVICE: New Life Box Respiratory Function Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Enhancing Facial Nerve Function With Omega-3 After Resection of Vestibular Schwannoma
Status: TERMINATED
Conditions: Vestibular Schwannoma
Interventions: DIETARY_SUPPLEMENT: Omega-3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Atezolizumab Combined With Split-dose Gemcitabine Plus Cisplatin in Urothelial Carcinoma
Status: COMPLETED
Conditions: Locally Advanced or Metastatic Urothelial Carcinoma
Interventions: DRUG: Atezolizumab 1200 mg/m2|DRUG: Gemcitabine 1000 mg/m2|DRUG: Cisplatin 70 mg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Six Month Trial of Lamotrigine vs. Sodium Valproate for Treatment of Mixed Mania
Status: COMPLETED
Conditions: Mixed Mania Bipolar Disorder
Interventions: DRUG: Lamotrigine|DRUG: Sodium Valproate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Multi-center Acute Efficacy Trial of GFX For Reduction of Glabellar Furrowing
Status: COMPLETED
Conditions: Glabellar Furrowing|Forehead Wrinkles
Interventions: DEVICE: GFX System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT