pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer
Status: NOT_YET_RECRUITING
Conditions: Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Head and Neck Squamous Cell Carcinoma|Hypopharyngeal Squamous Cell Carcinoma|Laryngeal Squamous Cell Carcinoma|Nasopharyngeal Squamous Cell Carcinoma|Oral Cavity Squamous Cell Carcinoma|Oropharyngeal Squamous Cell Carcinoma|Stage 0 Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8|Stage 0 Hypopharyngeal Carcinoma AJCC v8|Stage 0 Nasopharyngeal Carcinoma AJCC v8|Stage 0 Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage I Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8|Stage I Hypopharyngeal Carcinoma AJCC v8|Stage I Laryngeal Cancer AJCC v8|Stage I Lip and Oral Cavity Cancer AJCC v8|Stage I Nasopharyngeal Carcinoma AJCC v8|Stage I Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage II Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8|Stage II Hypopharyngeal Carcinoma AJCC v8|Stage II Laryngeal Cancer AJCC v8|Stage II Lip and Oral Cavity Cancer AJCC v8|Stage II Nasopharyngeal Carcinoma AJCC v8|Stage II Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8|Stage III Hypopharyngeal Carcinoma AJCC v8|Stage III Laryngeal Cancer AJCC v8|Stage III Lip and Oral Cavity Cancer AJCC v8|Stage III Nasopharyngeal Carcinoma AJCC v8|Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IVA Hypopharyngeal Carcinoma AJCC v8|Stage IVA Laryngeal Cancer AJCC v8|Stage IVA Lip and Oral Cavity Cancer AJCC v8|Stage IVA Nasopharyngeal Carcinoma AJCC v8|Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IVB Hypopharyngeal Carcinoma AJCC v8|Stage IVB Laryngeal Cancer AJCC v8|Stage IVB Lip and Oral Cavity Cancer AJCC v8|Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Interventions: OTHER: Best Practice|PROCEDURE: Biospecimen Collection|DRUG: Cisplatin|PROCEDURE: Computed Tomography|RADIATION: Image Guided Radiation Therapy|RADIATION: Intensity-Modulated Radiation Therapy|PROCEDURE: Magnetic Resonance Imaging|DRUG: MnSOD Mimetic BMX-001|DRUG: Placebo Administration|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Telomere Length in Predicting Toxicity in Older Patients With Stage III-IV Colorectal Cancer Undergoing Chemotherapy
Status: TERMINATED
Conditions: Mucinous Adenocarcinoma of the Colon|Mucinous Adenocarcinoma of the Rectum|Signet Ring Adenocarcinoma of the Colon|Signet Ring Adenocarcinoma of the Rectum|Stage IIIA Colon Cancer|Stage IIIA Rectal Cancer|Stage IIIB Colon Cancer|Stage IIIB Rectal Cancer|Stage IIIC Colon Cancer|Stage IIIC Rectal Cancer|Stage IV Colon Cancer|Stage IV Rectal Cancer
Interventions: OTHER: cytology specimen collection procedure|OTHER: laboratory biomarker analysis|OTHER: questionnaire administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase I, Open Interaction Study Between GLPG0634 and Midazolam in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG0634|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postmastecomy Internal Mammary Nodal Irradiation for High-risk Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: RADIATION: internal mammary nodal irradiation|RADIATION: no internal mammary nodal irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 1 Diabetes Mellitus on Basal Plus Mealtime Insulin
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: HOE901-U300 (new formulation of insulin glargine)|DRUG: Lantus (insulin glargine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of NBI-98854 in Children and Adolescents With Tourette Syndrome
Status: COMPLETED
Conditions: Tourette Syndrome
Interventions: DRUG: NBI-98854|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Treatment Duration of En-masse Versus Two Steps Retraction in Patients Having Maxillary Protrusion
Status: COMPLETED
Conditions: Bimaxillary Protrusion
Interventions: PROCEDURE: En masse retraction|PROCEDURE: Two-Step retraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adolescent Idiopathic Scoliosis and Proprioceptive Defect
Status: ACTIVE_NOT_RECRUITING
Conditions: Adolescent Idiopathic Scoliosis|Idiopathic Scoliosis|Scoliosis
Interventions: DIAGNOSTIC_TEST: Proprioceptive assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Berodual® Respimat® Compared to Berodual® MDI (Metered Dose Inhaler) in Asthma Patients
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Berodual® via Respimat®, high dose|DRUG: Berodual® via Respimat®, low dose|DRUG: Berodual® via MDI, high dose|DRUG: Placebo Respimat®|DRUG: Placebo MDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Response-guided Treatment of Luminal B-type Tumors and Luminal A-type Tumors With Node Metastases
Status: ACTIVE_NOT_RECRUITING
Conditions: Early-Stage Breast Carcinoma|Estrogen Receptor Positive Tumor
Interventions: DRUG: Paclitaxel|DRUG: Tamoxifen + Palbociclib|DRUG: Aromatase Inhibitor + Palbociclib|DRUG: Goserelin + Aromatase Inhibitor + Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Trauma Patients
Status: WITHDRAWN
Conditions: Acute Kidney Injury|Ischemia Reperfusion Injury
Interventions: DRUG: Valproic Acid Solution|DRUG: Isotonic saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Visually Inspired Patient Education Material on Willingness to Pursue Radiation Therapy
Status: RECRUITING
Conditions: Patient Education in Radiation Oncology
Interventions: BEHAVIORAL: Culturally Oriented Educational Brochure|BEHAVIORAL: Mayo Clinic Educational Booklet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety of Combining Modafinil and Nicotine Replacement Therapy in Treating Nicotine Dependent Adolescents
Status: COMPLETED
Conditions: Tobacco Use Disorder
Interventions: DRUG: ModafinilNicotine Replacement Therapy|DRUG: Modafinil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Niraparib Plus Anlotinib for Recurrent Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Carcinoma|Survival Outcomes|Adverse Events|Niraparib|Anlotinib|CA125|Chemotherapy|Targeted Therapy|Recurrent Ovarian Cancer
Interventions: COMBINATION_PRODUCT: Niraparib plus anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Women's Health Study (WHS): A Randomized Trial of Low-dose Aspirin and Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer
Status: COMPLETED
Conditions: Cardiovascular Diseases|Cerebrovascular Disorders|Coronary Disease|Heart Diseases|Myocardial Infarction|Myocardial Ischemia|Vascular Diseases
Interventions: DRUG: Aspirin|DRUG: Vitamin E|BEHAVIORAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Use of Etanercept in the Treatment of Moderate to Severe Lichen Planus
Status: TERMINATED
Conditions: Lichen Planus
Interventions: DRUG: Etanercept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Aprotinin on Transfusion Requirements in Patients Undergoing Elective Spinal Fusion Surgery
Status: TERMINATED
Conditions: Blood Loss, Surgical|Postoperative Hemorrhage
Interventions: DRUG: Trasylol (Aprotinin, BAYA0128)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Evaluation of iAPA-DC/CTL Combined Gemcitabine Therapy on Advanced Pancreatic Cancer
Status: UNKNOWN
Conditions: Carcinoma, Pancreatic Ductal
Interventions: OTHER: iAPA-DC/CTL adoptive cellular immunotherapy|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The SongDanceT1 Study: Stress, Ongoing Self- Monitoring and Diabetes, Nerve Stimulation and Cognitive Empowerment.
Status: ACTIVE_NOT_RECRUITING
Conditions: Autonomic Dysfunction|Stress, Psychological
Interventions: BEHAVIORAL: PPS guided selfcare based intervention program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of VX-950, Pegasys®, and Copegus® in Hepatitis C
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Telaprevir|DRUG: Ribavirin|DRUG: Pegylated Interferon Alfa 2a|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of TSL-1502 Capsules in Breast Cancer Patients With Germline BRCA Mutations
Status: RECRUITING
Conditions: Breast Cancer Metastatic
Interventions: DRUG: TSL-1502 capsules(low dose)|DRUG: TSL-1502 capsules(high dose)|DRUG: Investigator's choice of chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rifaximin 3 Times/Day (TID) for Non-Constipation Irritable Bowel Syndrome (IBS)
Status: COMPLETED
Conditions: Non-Constipation Irritable Bowel Syndrome
Interventions: DRUG: Rifaximin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Baidi Quzhi Granule Combined With Ju Ying Cream for Acne Vulgaris
Status: UNKNOWN
Conditions: Acne Vulgaris
Interventions: DRUG: BaidI Quzhi granule|DRUG: Ju Yin cream|DRUG: Baidi Quzhi placebo granule|DRUG: Ju Yin placebo cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Ipratropium Bromide in Preventing Exercise-induced Bronchoconstriction in Athletes
Status: COMPLETED
Conditions: Bronchospasm, Exercise-Induced
Interventions: DRUG: ipratropium bromide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Premixed Bioceramic Putty as an Apical Plug in Immature Anterior Permanent Teeth
Status: RECRUITING
Conditions: Periapical Periodontitis
Interventions: PROCEDURE: Mineral trioxide aggregate|PROCEDURE: Premixed Bioceramic Putty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stress Urinary Incontinence in Elite Athletes
Status: UNKNOWN
Conditions: Pelvic Floor Disorders
Interventions: BEHAVIORAL: Pelvic Floor Muscle Training (PFMT)|DIAGNOSTIC_TEST: Pad test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Prostaglandin E2 Tablets Versus Foley Catheter for Labor Induction
Status: UNKNOWN
Conditions: Labor, Induced
Interventions: DRUG: Prostin (PGE2) tablets|DEVICE: Foley catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Flexible Dose Titration Add-on Study to Treat Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Mecamylamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Controlled Trial of Patient Centered Telepsychiatry Interventions
Status: COMPLETED
Conditions: Mood Disorder|Anxiety Disorder|Substance Use Disorder
Interventions: BEHAVIORAL: telepsychiatry evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Ultrasound-Guided Botulinum Toxin Injections on Pain, Functionality, Spasticity, and Range of Motion in Patients With Post-Stroke Upper Extremity Spasticity
Status: WITHDRAWN
Conditions: Cerebrovascular Disorders|Spasticity, Muscle|Botulinum Toxin
Interventions: DRUG: Botulinum toxin type A|DRUG: %0,9 NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Safety, Tolerability and Drug Levels of Exenatide Implant
Status: NOT_YET_RECRUITING
Conditions: Overweight and Obesity|Type2diabetes
Interventions: COMBINATION_PRODUCT: Exenatide Implant|DRUG: Bydureon BCise (exenatide extended release)|DRUG: Semaglutide, 1.0 mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing Trametinib as a Potential Targeted Treatment in Cancers With BRAF Genetic Changes (MATCH-Subprotocol R)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Hematopoietic and Lymphoid Cell Neoplasm|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Multiple Myeloma
Interventions: DRUG: Trametinib Dimethyl Sulfoxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Explore the Role of Gut Flora in Psoriasis
Status: UNKNOWN
Conditions: Psoriasis|Psoriasis Vulgaris|Psoriasis Universalis|Psoriasis Face|Psoriasis Nail|Psoriatic Plaque|Psoriasis Diffusa|Psoriasis Punctata|Psoriasis Palmaris|Psoriasis Circinata|Psoriasis Annularis|Psoriasis Genital|Psoriasis of Scalp|Psoriasis Geographica
Interventions: OTHER: No Intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Preventive Ketamine on Postoperative Pain
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: DRUG: bupivacaine(intraperitoneally) and ketamine (intraperitoneally)|DRUG: bupivacaine(intraperitoneally) and ketamine (intravenously)|DRUG: bupivacaine(intraperitoneally)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Study of Megestrol Acetate Alone or in Combination With Testosterone Enanthate Drug in the Treatment of HIV-Associated Weight Loss
Status: COMPLETED
Conditions: HIV Infections|HIV Wasting Syndrome
Interventions: DRUG: Testosterone enanthate|DRUG: Megestrol acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: A Cluster Randomized Trial to Assess the Impact of Opinion Leader Endorsed Evidence Summaries on Improving Quality of Prescribing for Patients With Chronic Cardiovascular Disease
Status: COMPLETED
Conditions: Coronary Disease|Ischemic Heart Disease|Heart Failure
Interventions: BEHAVIORAL: Opinion leader generated and endorsed evidence summaries
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Clinical Outcome of Cyclosporine Short Infusion Versus Continuous Infusion Post Allogenic Stem Cell Transplantation
Status: COMPLETED
Conditions: Allogenic Bone Marrow Transplantation
Interventions: DRUG: Cyclosporin with a daily dose of 3 mg/kg/day intravenously over 2 h (short infusion) every 12 h
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparision of Blood Pressure Variability Between Amlodipine and Losartan
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Amlodipine|DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Assessment of Ventral Hernia Defects
Status: COMPLETED
Conditions: Ventral Incisional Hernia
Interventions: DIAGNOSTIC_TEST: Ultrasound Acoustic Radiation Forced Impulse Shear Wave Velocity
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Topical 0.1% Bromfenac Sodium and Prostaglandin E2 Inhibition in Cataract Surgery
Status: COMPLETED
Conditions: Cataract
Interventions: DRUG: 0.1% bromfenac ophthalmic solution|PROCEDURE: femtosecond laser cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study the Safety and Efficacy of Bone Marrow Derived Autologous Cells for the Treatment of Optic Nerve Disease
Status: UNKNOWN
Conditions: Optic Atrophy
Interventions: BIOLOGICAL: STEM CELL THERAPY
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB100 Administered Orally to Adults With Amyotrophic Lateral Sclerosis
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: BIIB100|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Small Bowel Capsule Endoscopy: Experience From a Single Large Tertiary Care Centre
Status: COMPLETED
Conditions: Small Bowel Disease|Small Bowel Ulcers|Capsule Endoscopy|Small Bowel Tumor
Interventions: PROCEDURE: Small Bowel Capsule Endosocopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pazopanib in Treating Patients With Newly Diagnosed or Locally and/or Regionally Recurrent Breast Cancer That Can Be Removed By Surgery
Status: TERMINATED
Conditions: Male Breast Carcinoma|Recurrent Breast Carcinoma|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer
Interventions: DRUG: Pazopanib Hydrochloride|PROCEDURE: Dynamic Contrast-Enhanced Magnetic Resonance Imaging|OTHER: Pharmacological Study|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study (This Means That no Drug is Tested) in Patients Suffering of Gastroesophageal Reflux Disease.
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease|Gastro-oesophageal Reflux|Gastro-Esophageal Reflux|Esophageal Reflux|GERD
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Of Blinatumomab For The Treatment Of Relapsed Or Refractory Indolent Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin Lymphoma
Interventions: DRUG: Blinatumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protective Effects of Propylene Glycol in Daily Acetaminophen Dosing
Status: COMPLETED
Conditions: Acetaminophen Toxicity
Interventions: DRUG: First Treatment Period|OTHER: Washout|DRUG: Second Treatment Period
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Selinexor in Combination With Clarithromycin, Pomalidomide and Dexamethasone for Relapsed Refractory Multiple Myeloma Patients
Status: TERMINATED
Conditions: Myeloma Multiple|Myeloma|Refractory Multiple Myeloma
Interventions: DRUG: Selinexor|DRUG: Clarithromycin|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib and Eribulin in Advanced Soft Tissue Sarcoma
Status: UNKNOWN
Conditions: Leiomyosarcoma|Liposarcoma|Soft Tissue Sarcoma Adult|Advanced Cancer
Interventions: DRUG: Eribulin|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of the Female Hormones on Cerebral Perfusion
Status: RECRUITING
Conditions: Cerebral Perfusion|Contraception|Menstrual Cycle
Interventions: DEVICE: MRI scan|DEVICE: Physiological monitoring|BIOLOGICAL: Blood sample|DEVICE: Blood pressure measurement|DEVICE: Body temperature|OTHER: Questionnaires|DIAGNOSTIC_TEST: Pregnancy test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of Liver Glucose Metabolism in Diabetic Subjects
Status: COMPLETED
Conditions: Newly Diagnosed Type 2 Diabetes (During the Last 12 Months)
Interventions: BIOLOGICAL: intravenous glucose tolerance test|BIOLOGICAL: hyperinsulinemic euglycemic clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Safety and Efficacy of Inclacumab in Participants With Sickle Cell Disease Experiencing Vaso-occlusive Crises
Status: COMPLETED
Conditions: Sickle Cell Disease|Vaso-occlusive Pain Episode in Sickle Cell Disease|Vaso-occlusive Crisis
Interventions: DRUG: Inclacumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgery With or Without Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: DRUG: FOLFOX regimen|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Dutasteride and Flex Dose of Tamsulosin on as Needed Basis, to Treat Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: Tamsulosin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ulipristal Acetate Versus GnRH Analogue Treatment Before Hysteroscopic Resection of Uterine Leiomyoma
Status: UNKNOWN
Conditions: Fibroid
Interventions: DRUG: ulipristal acetate|DRUG: Leuprolide acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Performance Evaluation of the AMIA APD Solution Generation System in Patients End Stage Renal Disease (ESRD)
Status: TERMINATED
Conditions: End Stage Renal Disease (ESRD)
Interventions: DEVICE: AMIA APD Solution Generation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRescription Exercise for Older Men With Urinary Disease
Status: RECRUITING
Conditions: Lower Urinary Tract Symptoms|Benign Prostatic Hyperplasia
Interventions: BEHAVIORAL: Exercise|OTHER: Calls and Newsletter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Automated Mechanical Peripheral Stimulation to Treat Freezing of Gait in Patients With Parkinson's Disease and STN-DBS
Status: UNKNOWN
Conditions: Parkinson Disease|Gait Disorders, Neurologic
Interventions: DEVICE: GONDOLA AMPS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colorectal Cancer Awareness, Research, Education and Screening (CARES)
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: OTHER: Immunochemical Fecal Occult Blood Test (I-FOBT) Kit|OTHER: Standard Intervention (SI) Educational Materials|OTHER: CARES Intervention Educational Materials|OTHER: Baseline Visit Survey|OTHER: Follow-up Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Safety Study of Adenovirus/PNP Coupled With Fludarabine Phosphate to Treat Solid Tumors
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: GENETIC: Ad/PNP and fludarabine monophosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of VivaSightTM Double Lumen Tube With a Conventional Double Lumen Tube
Status: COMPLETED
Conditions: Endotracheal Intubation|Airway Management|One Lung Ventilation
Interventions: DEVICE: Standard double lumen tube|DEVICE: VivaSight double lumen tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Nucleoside Supplementation or Switch to Tenofovir in Reversing Fat Loss in HIV Infected Adults
Status: COMPLETED
Conditions: HIV Infections|Lipodystrophy|Metabolic Diseases|Nutrition Disorders
Interventions: DRUG: NucleomaxX|DRUG: Tenofovir Disoproxil Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Assess the Safety, Tolerability and Pharmacokinetics of GS-9411 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: GS-9411|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First-in-Human Study of alpha1H in Patients With Non-muscle Invasive Bladder Cancer
Status: UNKNOWN
Conditions: Non-muscle Invasive Bladder Cancer
Interventions: DRUG: alpha1H, 7.4 mg/mL|OTHER: placebo|DRUG: alpha1H, 37 mg/mL|DRUG: alpha1H, 74 mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Epicutaneously Applied Ketoprofen Transfersome® Gel With or Without Combination With Oral Celecoxib for the Treatment of Muscle Pain Induced by Eccentric Exercise
Status: COMPLETED
Conditions: Musculoskeletal Pain
Interventions: DRUG: Celecoxib, Ketoprofen|DRUG: Ketoprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: LASER and Radiofrequency and Genitourinary Syndrome of Menopause
Status: ENROLLING_BY_INVITATION
Conditions: Postmenopausal Atrophic Vaginitis|Postmenopausal Symptoms|Genitourinary Symptoms
Interventions: PROCEDURE: LASER|PROCEDURE: Microablative Radiofrequency|DRUG: Estriol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tocilizumab Delivered Via Pleural and Peritoneal Catheters in Patients With Advanced Metastatic Cancer
Status: RECRUITING
Conditions: Malignant Pleural Effusion|Malignant Ascites
Interventions: DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Itacitinib for Low Risk GVHD
Status: COMPLETED
Conditions: Low Risk Acute Graft-versus-host Disease|Graft-versus-host-disease|GVHD
Interventions: DRUG: Itacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Characterize the Absorption, Metabolism, and Excretion of 14C-JNJ-53718678 After a Single Oral Dose in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-53718678
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relaxation With Virtual Reality on Fatigue and Comfort in Hemodialysis Patients
Status: COMPLETED
Conditions: Chronic Kidney Diseases
Interventions: OTHER: Relaxation with virtual reality|OTHER: Attention match
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Proof of Concept Treatment Study of Orally Administered VH4004280 or VH4011499 in HIV-1 Infected Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections
Interventions: DRUG: VH4004280|DRUG: VH4011499|DRUG: VH4004280 Matching Placebo|DRUG: VH4011499 Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the QOL Evaluation of Trelagliptin in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Trelagliptin|DRUG: Daily DPP-4 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propylene Mesh VS Standard Customized Palatal Stent as Protective Mechanical Barrier
Status: UNKNOWN
Conditions: Randomized Controlled Trial, Human Study
Interventions: DEVICE: propylene mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Popliteal SNB:Evaluation of Block Dynamics After Subparaneural Injection Below CPN & TN
Status: COMPLETED
Conditions: Musculoskeletal Diseases or Conditions
Interventions: PROCEDURE: Popliteal Sciatic nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Metformin Hydrochloride Extended Release 500 mg Tablet Versus Glucophage XR® 500 mg Tablet in Healthy Volunteers Under Fed Conditions
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: An Exploratory, Randomized, Blinded, Placebo-Controlled Trial of Folic Acid and L-methylfolate in Parkinson's Disease
Status: TERMINATED
Conditions: Parkinson's Disease
Interventions: DIETARY_SUPPLEMENT: Folic Acid, Vitamin B6, Vitamin B12|DIETARY_SUPPLEMENT: B6, B12, L-methylfolate|DIETARY_SUPPLEMENT: B6, B12, Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of the Immediate Implant Loading
Status: COMPLETED
Conditions: Implant Site Reaction
Interventions: PROCEDURE: Direct provisional technique|PROCEDURE: Indirect Provisional technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Risk-Stratified Treatment in Newly Diagnosed Infant Leukemia
Status: NOT_YET_RECRUITING
Conditions: Leukemia, Lymphoid
Interventions: DRUG: Consolidation #4(without daunorubicin)|DRUG: Consolidation #4(with daunorubicin)|DRUG: Allogeneic hematopoietic stem cell transplantation after Consolidation #4(with daunorubicin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Consumption of a Milk Product Designed for Lactating Women on Human Milk Composition
Status: NOT_YET_RECRUITING
Conditions: Lactating Mothers|Infants
Interventions: DIETARY_SUPPLEMENT: Fortified powder milk|OTHER: Powder milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Personalized B-fructan Diet in Inflammatory Bowel Disease Patients
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases|Ulcerative Colitis
Interventions: OTHER: Placebo Comparator: Randomized pectin diet|OTHER: Randomized B-fructan diet|OTHER: Personalized pectin diet|OTHER: Personalized B-fructan diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Investigating Hearing With Ponto 3 SuperPower, a Bone Anchored Hearing Aid - Investigating Hear
Status: UNKNOWN
Conditions: Hearing Loss, Conductive|Hearing Loss Mixed|Hearing Disability|Conductive Hearing Loss|Ear Diseases|Conductive Hearing Loss, Bilateral|Conductive Hearing Loss, Unilateral
Interventions: DEVICE: Collection of Pure tone thresholds from audiogram measured prior to fitting of Ponto 3 SuperPower|DEVICE: Collection of BC In-situ thresholds from BC In-situ audiogram measured during fitting of Ponto 3 SuperPower|DEVICE: Collection of Aided sound field thresholds measured with the Ponto 3 SuperPower|DEVICE: Collection of speech intelligibility scores|DEVICE: Skin reaction|DEVICE: Collection of Glasgow Benefit Inventory|DEVICE: Collection of power-on usage time with Ponto 3 SuperPower
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TSR-042 as Maintenance Therapy for Patients With High-risk Locally Advanced Cervical Cancer After Chemo-radiation (ATOMICC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Cancer|Advanced Cancer
Interventions: OTHER: No Further Treatment|DRUG: TSR-042
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Continuous Infusion ch14.18/CHO Plus s.c. Aldesleukin (IL-2)
Status: UNKNOWN
Conditions: Neuroblastoma
Interventions: DRUG: ch14.18/CHO|DRUG: Aldesleukin|DRUG: Isotretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Closed-loop Insulin Therapy in Adults Prone to Hypoglycemia
Status: UNKNOWN
Conditions: Type 1 Diabetes Mellitus With Hypoglycemia
Interventions: DEVICE: Closed-loop insulin infusion driven by continuous glucose monitoring through an algorithm, in free-life conditions|DEVICE: Continuous Subcutaneous Insulin Infusion and Continuous Glucose Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antibiotic Prophylaxis for Neurogenic Bladder Botox
Status: NOT_YET_RECRUITING
Conditions: Neurogenic Bladder|Post-operative Urinary Tract Infections
Interventions: DRUG: Ciprofloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 1, Dose-escalation Study of MEDI-551 in Japanese Adult Patients With Relapsed or Refractory Advanced B-cell Malignancies
Status: COMPLETED
Conditions: Blood Cancer|Advanced B Cell Malignancies
Interventions: DRUG: MEDI-551
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Radiographic Assessment of Platelet Rich Fibrin and Mineral Trioxide Aggregate as Pulp Capping Biomaterials
Status: UNKNOWN
Conditions: Direct Pulp Capping
Interventions: OTHER: direct pulp capping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrating Community Interventions to Eliminate Neglected Tropical Diseases
Status: COMPLETED
Conditions: Rabies in Animals|Worms; Intestine
Interventions: OTHER: integrated delivery of deworming and vaccination|OTHER: Mass deworming only|OTHER: Mass vaccination of dogs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dose Dense Carboplatin, Taxotere and Herceptin As Primary Systemic Therapy in Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: trastuzumab, docetaxel and carboplatin in dose dense regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug to Drug Interaction Study of Sotagliflozin With Midazolam and Metoprolol
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: sotagliflozin (SAR439954)|DRUG: midazolam|DRUG: metoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Hormonal Contraceptives on Androgens and Glucose Metabolism
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Desogestrel-Ethinyl Estradiol contraceptive pill|DRUG: Etonogestrel-Ethinyl Estradiol vaginal ring|DRUG: Norelgestromin-Ethinyl Estradiol contraceptive patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Femoralis, n Femoralis and m Iliopsoas Tendon Sonoanatomy According to Age Groups in Children
Status: COMPLETED
Conditions: Anatomic Abnormality|Anatomy|Pediatrics|Anatomic Landmarks|Anthropometry
Interventions: DEVICE: ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Demonstrate the Relative Bioavailability of Clarithromycin 250 mg Tablets Under Non-Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Clarithromycin 250 mg Tablets (Geneva Pharmaceuticals, USA)|DRUG: Biaxin (Clarithromycin) 250 mg Tablets (Abbott Laboratories, Inc, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Observation of Botulinum Toxin A Treatment in the Treatment of Rosacea
Status: RECRUITING
Conditions: Rosacea|Botulinum Toxin
Interventions: DRUG: Botulinum Toxin Type A Injection [Botox]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Radium-223 and Lutetium-177 PSMA-I&T in Men With Metastatic Castration-Resistant Prostate Cancer
Status: RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer|mCRPC|Prostate Cancer
Interventions: DRUG: Lutetium-177 PSMA-I&T|DRUG: Radium-223
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Comparison of 2 Fixation Techniques for Unstable Intertrochanteric Hip Fractures
Status: COMPLETED
Conditions: Hip Fractures
Interventions: DEVICE: Dynamic Hip Screw (DHS); Trochanteric Fixation Nail (TFN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Zinc Supplementation on Response to Oral Polio Vaccine in Infants in Pakistan
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: DRUG: Zinc Sulfate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Cervical Collar on Intracranial Pressure
Status: COMPLETED
Conditions: Optic Nerve Sheath Diameter|Ultrasonography
Interventions: DEVICE: Ambu Perfect ACE|DEVICE: Philly One-Peace Collar|DEVICE: Necloc Collar|DEVICE: NexSplit Plus|DEVICE: NECKLITE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Safety and Tolerability of Multiple Doses of EO2002
Status: RECRUITING
Conditions: Corneal Edema|Corneal Endothelial Dystrophy|Endothelial Dysfunction|Fuchs Dystrophy|Fuchs' Endothelial Dystrophy|Bullous Keratopathy|Pseudophakic Bullous Keratopathy|Corneal Edema Pseudophakic
Interventions: BIOLOGICAL: EO2002|DRUG: Ripasudil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Therapeutic Ultrasound in the Treatment of Calcific Tendinitis of the Shoulder
Status: UNKNOWN
Conditions: Rotator Cuff Tendinitis|Shoulder Pain|Musculoskeletal Diseases
Interventions: DEVICE: Sonopuls 490u, Enraf-Nonius, Rotterdam, Kingdom of the Netherlands|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Development of a Model-based Working Memory Training and Investigation of Its Comparative Efficacy
Status: COMPLETED
Conditions: Working Memory
Interventions: OTHER: model-based WM training|OTHER: single-task WM training|OTHER: multiple-task WM training|OTHER: sham intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Sympathetic Activity in Patients With End-stage Renal Disease on Peritoneal Dialysis
Status: COMPLETED
Conditions: End-stage Renal Disease (ESRD)|Kidney Disease
Interventions: OTHER: DIANEAL|OTHER: EXTRANEAL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety, Tolerability and Pharmacokinetics of CT-P59 in Healthy Subjects
Status: COMPLETED
Conditions: SARS-CoV-2 Infection
Interventions: DRUG: CT-P59|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: A Prospective, Single Center, Single-Arm Clinical Study of 20 Participants to Reduce the Appearance of the Peri-orbital Wrinkles. Participants Will Receive up to Four Treatments With Tixel Every 4 Weeks. Follow-up Will Occur 1 Month and 3 Months Following Last Treatment.
Status: UNKNOWN
Conditions: Wrinkle
Interventions: DEVICE: Tixel 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nicotine Lozenges for Treatment of Smokeless Tobacco Addiction
Status: COMPLETED
Conditions: Smokeless Tobacco Use
Interventions: DRUG: Nicotine Lozenges|DRUG: Placebo lozenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antioxidant Responses to Exercise and Cherry Consumption
Status: COMPLETED
Conditions: Dietary Modification
Interventions: DIETARY_SUPPLEMENT: Tart cherry Juice|OTHER: High-fat meal|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Radiation Therapy With Pembrolizumab and Olaparib or Other Radiosensitizers in Women Who Have Triple-Negative or Hormone-Receptor Positive/Her2 Negative Breast Cancer
Status: RECRUITING
Conditions: Triple Negative Breast Cancer|TNBC - Triple-Negative Breast Cancer|Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Olaparib|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Potential Effectiveness of the Diabetes Prevention Program in the Peri-urban Area of Bamako, Mali
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Diabetes prevention program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Determine the Safety, Tolerability, and Pharmacokinetics of GDC-0310 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: GDC-0310|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
Status: RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction|Obesity
Interventions: OTHER: HeO2 gas mixture|OTHER: Room air gas mixture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER