pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Tolerability of Single and Multiple Doses of VAK694 in Healthy and Atopic Subjects
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: NVP-VAK694|DRUG: NVP-VAK694
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Contribution of Nasal IgE Production to the Boost of Systemic Allergen-specific IgE Upon Nasal Allergen Contact
Status: RECRUITING
Conditions: Allergy
Interventions: PROCEDURE: Blood sampling|PROCEDURE: Nasal biopsies|BIOLOGICAL: Nasal specimen collection|PROCEDURE: Mucosal RNA sampling|PROCEDURE: Intranasal challenge|PROCEDURE: Skin prick test|PROCEDURE: Peak Nasal Inspiratory Flow (PNIF)|BIOLOGICAL: Pregnancy test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: High Dose Rate (HDR) Versus Low Dose Rate (LDR) Brachytherapy in Carcinoma Cervix
Status: COMPLETED
Conditions: Cancer of Cervix|Cervical Cancer|Cancer of the Cervix|Cervix Cancer
Interventions: PROCEDURE: HIgh Dose Rate Vs Low DOse Rate Brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Traditional Print Communication Methods, Simple Electronic Communication Methods, or Usual Care in Increasing How Often Older Women Undergo Colorectal Cancer Screening
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: OTHER: educational intervention via internet|OTHER: educational intervention mailed|OTHER: No additional educational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy And Safety Study Of Pregabalin (Lyrica) As Monotherapy In Patients With Partial Seizures
Status: TERMINATED
Conditions: Epilepsies, Partial
Interventions: DRUG: pregabalin 600 mg/day|DRUG: pregabalin 150 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vicriviroc in HIV(R5/X4)-Treatment Experienced Subjects (Study P05057AM5)(COMPLETED)
Status: COMPLETED
Conditions: HIV Infections|Acquired Immunodeficiency Syndrome
Interventions: DRUG: Vicriviroc|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Antitumoral Efficacy of Nivolumab After SIRT for the Treatment of Patients With HCC
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Nivolumab|DEVICE: SIR-Spheres
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ARIA (Atacand Renoprotection In NephropAthy Pt.)
Status: COMPLETED
Conditions: Non-diabetic Nephropathy With Hypertension
Interventions: DRUG: Candesartan Cilexetil|DRUG: Candesartan Cilexetil|DRUG: Candesartan Cilexetil 32mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yoga in Treating Sleep Disturbance in Cancer Survivors
Status: COMPLETED
Conditions: Fatigue|Cancer|Sleep Disorders
Interventions: PROCEDURE: Standard Care Control Condition|PROCEDURE: Yoga Intervention (YOCAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Characterization of the Long-term Safety, Efficacy, and Pharmacodynamics Revestive® in the Management of Short Bowel Syndrome Pediatric Patients
Status: COMPLETED
Conditions: Short Bowel Syndrome
Interventions: DRUG: Teduglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study
Status: COMPLETED
Conditions: Pain|Postoperative Period
Interventions: OTHER: NSS|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Long Term Safety and Efficacy of DWP16001 Compared to Placebo in the Treatment of T2DM.
Status: COMPLETED
Conditions: T2DM (Type 2 Diabetes Mellitus)
Interventions: DRUG: DWP16001 Amg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Micro-filaments to Detect "Fast Ripples" and Improve the Identification of the Epileptogenic Zone
Status: RECRUITING
Conditions: Epilepsy, Refractory
Interventions: DEVICE: macro-micro tetrodes for intracranial recording
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of Different Amounts of Tablets of a New and a Marketed Tablet Formulation in Healthy Adults
Status: WITHDRAWN
Conditions: Opioid-Related Disorders|Pain, Acute|Pain, Postoperative
Interventions: DRUG: GRT7014 - Abuse Deterrend Tablet|DRUG: Norco 5Mg-325Mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HepaSphere Interventional Therapy Using Digital Subtraction Angiography（DSA） for Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma
Interventions: PROCEDURE: interventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genicular Nerve Block in Juvenile Idiopathic Arthritis
Status: COMPLETED
Conditions: Juvenile Idiopathic Arthritis|Persistent Knee Arthritis|no Intra-articular Injection in the Last 3 Months|no Other Cause for Chronic Kneearthritis
Interventions: DRUG: genicular nerve block|DRUG: intra-articular steroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Nicotinamide-based Supportive Therapy in Lymphopenia for Patients With COVID-19
Status: COMPLETED
Conditions: Covid19|Lymphopenia
Interventions: DRUG: nicotinamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase I/II of LB-100 Plus Doxorubicin vs. Doxorubicin Alone in First Line of Advanced Soft Tissue Sarcomas
Status: RECRUITING
Conditions: Advanced Soft-tissue Sarcoma
Interventions: DRUG: LB-100 plus Doxorrubicin|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of FISH Intake on MEtabolic Health in a Diabetic South Asian popuLation (FISH MEAL)
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Tinned mackerel fish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sulphate-bicarbonate-calcium Water, Body Weight and Gut Microbiota
Status: WITHDRAWN
Conditions: Overweight|Obesity
Interventions: DIETARY_SUPPLEMENT: "Acqua Santa di Chianciano"® (sulphate-bicarbonate-calcium water)|DIETARY_SUPPLEMENT: Tap water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Organ Dysfunction and Mortality by Monitoring the Administration of Opioids and Hypnotics in Patients at High Postoperative Risk
Status: RECRUITING
Conditions: Sedation and Analgesia Monitoring
Interventions: PROCEDURE: anesthesia guided by sedation and analgesia monitoring|PROCEDURE: anesthesia performed according only to the clinical judgment of the anesthetist as usual practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Using BCG to Protect Senior Citizens During the COVID-19 Pandemic
Status: COMPLETED
Conditions: Covid19|Non-specific Effects of Vaccines|Heterologous Immunity|Morbidity|Immunosenescence|Vaccine Preventable Disease
Interventions: BIOLOGICAL: BCG-Denmark|BIOLOGICAL: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Feasibility, Acceptability and Clinical Utility of a New Remote-mobile Technology Intervention (ASARM) for CFS/ME in a Paediatric Population
Status: COMPLETED
Conditions: Chronic Fatigue Syndrome
Interventions: DEVICE: ASARM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COmparison of Bleeding Risk Between Rivaroxaban and Apixaban in Patients With Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: Apixaban|DRUG: Rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate RAD001 in Combination With Radiotherapy in Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer|Locally Advanced Disease
Interventions: DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety, Tolerability and Efficacy of V3381 in Patients With Diabetic Peripheral Neuropathic Pain
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathic Pain
Interventions: DRUG: V3381|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IMMUNERECOV CONTRIBUTES TO IMPROVEMENT OF RESPIRATORY AND IMMUNOLOGICAL RESPONSE IN POST-COVID-19 PATIENTS.
Status: RECRUITING
Conditions: Long Covid19|Dietary Supplements|Respiratory Tract Infections|Inflammation
Interventions: DIETARY_SUPPLEMENT: Nutritional blend (ImmuneRecov).
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yoga and Bolus Lukewarm Saline as Rapid Colonoscopy Preparation
Status: COMPLETED
Conditions: Colonic Neoplasms
Interventions: DRUG: Normal (0.9%) saline|DRUG: HalfLytely
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Effect of a Newly Formulated Tetracaine Product PET500 on Penile Skin Sensation
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Tetracaine|OTHER: Matching placebo (PET500)|DRUG: STUD100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: R-ABVD vs ABVD-RT in Early Stage Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Hodgkin Lymphoma
Interventions: DRUG: Rituximab|RADIATION: Involved field irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Using a 'Virtual Clinic' in Urogynaecology Improve Patient Experience and Reduce Cost?
Status: COMPLETED
Conditions: Pelvic Floor Disorders
Interventions: OTHER: ePAQ-PF followed by a telephone consultation.|OTHER: ePAQ-PF followed by a face to face consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Vedolizumab Subcutaneously (SC) as Maintenance Therapy in Ulcerative Colitis
Status: COMPLETED
Conditions: Colitis, Ulcerative
Interventions: DRUG: Vedolizumab 300 mg IV|DRUG: Placebo IV|DRUG: Vedolizumab 108 mg SC|DRUG: Placebo SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Echocardiography by Non-cardiologist in Early Management of Patients With Chest Pain
Status: UNKNOWN
Conditions: Cardiology|Acute Coronary Syndrome|Echocardiography
Interventions: DEVICE: ECHOcardiography, Point-of-Care UZ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Maltese Antibiotic Stewardship Programme in the Community (MASPIC): Antibiotic Prescribing for Acute Respiratory Tract Complaints
Status: COMPLETED
Conditions: Acute Respiratory Infection
Interventions: BEHAVIORAL: Delayed antibiotic prescription|BEHAVIORAL: Antibiotic prescribing guidelines|BEHAVIORAL: Education|BEHAVIORAL: Educational materials
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Evaluation of the New Hypoxia Imaging Agent HX4
Status: COMPLETED
Conditions: Head and Neck Cancer|Lung Cancer|Liver Cancer
Interventions: DRUG: [F-18] FMISO|DRUG: [F-18] HX4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Study of Efficacy and Safety of Oral Ibuprofen and Intravenous Ibuprofen in Closure of Patent Ductus Arteriosus in Very Low Birth Weight Infants
Status: COMPLETED
Conditions: Patent Ductus Arteriosus
Interventions: DRUG: oral ibuprofen|DRUG: intravenous ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Staged Versus Simultaneous Bilateral Knee Arthroplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Simultaneous Knee Arthroplasty (UKA)|PROCEDURE: Staged Knee Arthroplasty (UKA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of a Novel Device to Clean the Endotracheal Tube
Status: COMPLETED
Conditions: Endotracheal Extubation|Airway Obstruction|Airway Control|Pneumonia, Ventilator-Associated|Breathing Mechanics
Interventions: DEVICE: ETT cleaning maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Client-Centered Counseling During Routine/Opt-Out HIV-Testing in Uganda
Status: COMPLETED
Conditions: HIV|Sexual Behavior
Interventions: BEHAVIORAL: Motivational interviewing intervention during HIV testing|BEHAVIORAL: Standard-of-care counseling during HIV testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Treatment Comparison in Chronic Pain
Status: COMPLETED
Conditions: Comparison of Different Treatment for Chronic Pain
Interventions: BEHAVIORAL: Self-hypnosis/self-care|BEHAVIORAL: Music/self-care|BEHAVIORAL: Self-care|BEHAVIORAL: Psycho-education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Control Trial of Booster Seat Education Material to Increase Perceived Benefit Among Parents
Status: COMPLETED
Conditions: Wounds and Injuries
Interventions: BEHAVIORAL: Transport Canada material|BEHAVIORAL: Enhanced material
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of CS-1008 in Combination With FOLFIRI in Patients Who Have Failed Other Treatments
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: CS-1008|DRUG: FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prednisolone Novel Endpoint Study in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluate ALLN-177 in Patients With Enteric Hyperoxaluria
Status: COMPLETED
Conditions: Enteric Hyperoxaluria
Interventions: DRUG: ALLN-177|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Oral Bioavailability Study of Different Fixed Dose Combinations of Dolutegravir and Rilpivirine in Healthy Subjects
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: DTG 50 mg|DRUG: RPV 25 mg|DRUG: DTG/RPV 50 mg/25 mg: Product Code AS|DRUG: DTG/RPV 50 mg/25 mg: Product Code AM|DRUG: DTG/RPV 50 mg/25 mg: Product Code AQ|DRUG: DTG/RPV 50 mg/25 mg: Product Code AK|DRUG: DTG/RPV 50 mg/25 mg: Product Code AR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrinsic PEEP and Laryngeal Aperture in COPD
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: PROCEDURE: Oesophageal balloon to measure intra-thoracic pressure|PROCEDURE: Fibre-optic laryngoscopy|OTHER: standard lung function tests|PROCEDURE: face mask CPAP|PROCEDURE: variation of mouth pressure with CPAP|OTHER: facemask pneumotachograph
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: In Vivo Quantification of Dental Demineralisation Using OCT With and Without Esomeprazole
Status: COMPLETED
Conditions: Tooth Erosion
Interventions: DRUG: Esomeprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Chemotherapy Followed by Zevalin for Relapsed Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Fludarabine|DRUG: Mitoxantrone|DRUG: Rituximab|DRUG: Zevalin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarker for Duchenne Muscular Dystrophy
Status: COMPLETED
Conditions: Increased Lordosis/Scoliosis|Hyporeflexia|Duchenne Muscular Dystrophy|Red-Green Color Blindness|Lordosis|Scoliosis|Muscular Atrophy|Muscular Weakness
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SCH 66336 Before Surgery in Treating Patients With Colorectal Cancer That Has Metastasized to the Liver
Status: WITHDRAWN
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: DRUG: SCH 66336|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nicotine Virtual Reality Conditioned Place Preference
Status: WITHDRAWN
Conditions: Nicotine Addiction|Nicotine Use Disorder
Interventions: DRUG: Nicotine|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Manual of Emotional Regulation and Interpersonal Abilities in Children and Adolescents Group Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Domestic Violence|Psychotherapy, Group|Witness
Interventions: BEHAVIORAL: Emotional Regulation and Interpersonal Abilities group Therapy (MERITA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate Long-term Safety and Clinical Activity of Givosiran (ALN-AS1) in Patient With Acute Intermittent Porphyria (AIP)
Status: COMPLETED
Conditions: Acute Intermittent Porphyria
Interventions: DRUG: Givosiran
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PREMOM-II: Pregnancy Remote Monitoring of Women With Gestational Hypertensive Disorders
Status: RECRUITING
Conditions: Gestational Hypertension
Interventions: DEVICE: Telemonitoring|OTHER: Longitudinal CV profiling during pregnancy and before and after the start/switch of antihypertensive medication|OTHER: CV profiling before and after the start/switch of antihypertensive medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Multicenter Study of EasyTube® Compared to Endotracheal Tube in General Anesthesia
Status: COMPLETED
Conditions: Airway Morbidity
Interventions: DEVICE: EasyTube|DEVICE: Endotracheal tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Rituximab in Opsoclonus-Myoclonus in Children With Neuroblastoma
Status: TERMINATED
Conditions: Neuroblastoma|Opsoclonus-myoclonus
Interventions: DRUG: anti-CD20 (Rituximab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigational Study of Hydrocortisone
Status: COMPLETED
Conditions: Adrenal Insufficiency
Interventions: DRUG: Hydrocortisone granules|DRUG: Hydrocortisone Tablet|DRUG: i.v. Hydrocortisone Injection|OTHER: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Role of ASpirin in Placental and Maternal Endothelial Cell Regulation IN Pre-eclampsia
Status: RECRUITING
Conditions: Pre-Eclampsia
Interventions: DRUG: Acetylsalicylic Acid 81 mg|DRUG: Acetylsalicylic Acid 162 mg|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Early Intervention for Suicide Risk Among Immigrant Youth
Status: UNKNOWN
Conditions: Family Conflict|Suicidal Ideation
Interventions: BEHAVIORAL: Early Intervention for Suicide Risk Among Immigrant Youth|BEHAVIORAL: Enhanced usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypoglycaemia and Cardiac Arrhythmias in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Arrhythmia, Cardiac
Interventions: OTHER: Combined hyper- and hypoglycaemic clamp|DEVICE: Loop recorder (Reveal LINQ, Medtronic, Minneapolis, MN, USA)|DEVICE: Continuous glucose monitoring (iPro2, Medtronic, Minneapolis, MN, USA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Etoricoxib as an Additive Analgesic to Epidural Analgesia in Colon or Rectal Fast-track Surgery
Status: TERMINATED
Conditions: Post-operative Pain
Interventions: DRUG: Arcoxia®120 mg|DRUG: P Tablet White Lichtenstein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alterations of Functional Activities and Leg Stiffness After Hamstring Lengthening in Cerebral Palsy Children
Status: COMPLETED
Conditions: Cerebral Palsy|Crouch Gait
Interventions: BEHAVIORAL: cerebral palsy|BEHAVIORAL: crouch gait
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lactoferrin Versus Ferrous Sulfate in Management of Iron Deficiency Anemia Among Female Medical Ain Shams Students
Status: COMPLETED
Conditions: Iron Deficiency Anemia
Interventions: DRUG: Lactoferrin|DRUG: Ferrous sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Effectiveness of the Endoscopic Surgical Instrument Control System (SP1000).
Status: UNKNOWN
Conditions: Urologic Neoplasms
Interventions: DEVICE: endoscopic surgical instrument control system (SP1000: single-port laparoscopy)|DEVICE: endoscopic surgical instrument control system (IS3000: multi-port laparoscopy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: R21/Matrix-M in African Children Against Clinical Malaria
Status: ACTIVE_NOT_RECRUITING
Conditions: Malaria
Interventions: BIOLOGICAL: R21/Matrix-M|BIOLOGICAL: Rabies vaccine or Hepatitis A vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Two Forms of Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS
Status: COMPLETED
Conditions: Cytomegalovirus Retinitis|HIV Infections
Interventions: DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparative Efficacy and Safety Study of RGB-14-P and Prolia® in Women With Postmenopausal Osteoporosis
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: RGB-14-P|DRUG: Prolia®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Time-restricted Eating on Catecholamine-sensitivity of Adipose Tissue in Obese Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: BEHAVIORAL: Standard of Care|BEHAVIORAL: Time Restricted Eating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Cross Frequency tACS on Cognitive Control
Status: COMPLETED
Conditions: Cognitive Control|Executive Function
Interventions: DEVICE: Theta-gamma tACS|DEVICE: Delta-beta tACS|DEVICE: Sham tACS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Cochlear Baha 5 SuperPower Sound Processor on the Baha Attract System
Status: COMPLETED
Conditions: Single Sided Sensorineural Deafness|Mixed Hearing Loss, Unilateral
Interventions: DEVICE: Baha 5 SuperPower on Baha Attract System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study Using Combined Virtual 4-D Electromagnetic (EM) Tip-Tracked Devices & EBUS in Diagnosis of Lung Nodules
Status: COMPLETED
Conditions: Lung Cancer
Interventions: PROCEDURE: Navigational Bronchoscopy|PROCEDURE: Standard Bronchoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Test Different Doses of BI 765049 Alone and in Combination With Ezabenlimab in Asian People With Advanced Cancer (Solid Tumours) Positive for B7-H6
Status: RECRUITING
Conditions: Gastrointestinal Cancer|Lung Cancer|Pancreatic Cancer|Colorectal Cancer|Head and Neck Cancer|Liver Cancer
Interventions: DRUG: BI 765049|DRUG: Ezabenlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel, Bevacizumab And Adjuvant Intraperitoneal Carboplatin in Treating Patients Who Had Initial Debulking Surgery for Stage II, Stage III, or Stage IV Ovarian Epithelial, Primary Peritoneal, or Fallopian Tube Cancer
Status: COMPLETED
Conditions: Brenner Tumor|Fallopian Tube Cancer|Ovarian Clear Cell Cystadenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Mixed Epithelial Carcinoma|Ovarian Mucinous Cystadenocarcinoma|Ovarian Serous Cystadenocarcinoma|Ovarian Undifferentiated Adenocarcinoma|Primary Peritoneal Cavity Cancer|Stage II Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer
Interventions: PROCEDURE: adjuvant therapy|DRUG: paclitaxel|DRUG: carboplatin|BIOLOGICAL: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of IgM Rich Immunoglobulin With Antibiotics for Bacterial Sepsis in Very Low Birth Weight Preterm Neonates
Status: COMPLETED
Conditions: Neonatal SEPSIS|Very Low Birth Weight Baby
Interventions: DRUG: IgM rich Immunoglobin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft
Status: COMPLETED
Conditions: Limbal Stem Cell Deficiency
Interventions: PROCEDURE: Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft|BIOLOGICAL: Cultivation of Limbal epithelial cells into a graft|PROCEDURE: CALEC Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analysis of Prostatic Arterial Embolization for Benign Prostatic Hyperplasia Using Embosphere Microspheres
Status: WITHDRAWN
Conditions: Benign Prostatic Hyperplasia
Interventions: DEVICE: Prostate Arterial Embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Safety and Efficacy of a High Dose of Eteplirsen in Participants With Duchenne Muscular Dystrophy (DMD) (MIS51ON)
Status: ACTIVE_NOT_RECRUITING
Conditions: Muscular Dystrophy, Duchenne
Interventions: DRUG: Eteplirsen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short Versus Long Post-Operative Restrictions Following Lumbar Discectomy
Status: UNKNOWN
Conditions: Lumbar Disc Herniation
Interventions: BEHAVIORAL: Two-Week Post-Operative Restriction|BEHAVIORAL: Six-Week Post-Operative Restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Melatonin on Palatal Wound Healing (Randomized Controlled Clinical Trial)
Status: UNKNOWN
Conditions: Wound Heal
Interventions: DRUG: Melatonin|DRUG: Carbopol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Childhood Constraint Therapy in Cerebral Palsy
Status: UNKNOWN
Conditions: Cerebral Palsy
Interventions: BEHAVIORAL: Soft Mitt Constraint Therapy for Sensory/Motor Impairment in Cerebral Palsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical, Radiological and Microbiological Outcomes of Implants With Two Different Connection Configurations, a Split-mouth RCT.
Status: UNKNOWN
Conditions: Bone Loss, Alveolar|Dental Implant Failed
Interventions: DEVICE: Rehabilitation with dental implant with internal hexagon connection|DEVICE: Rehabilitation with dental implant with conical connection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fasting Bioequivalence Study of 2 Metformin 500 mg Prolonged Release Tablets in 44 Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Metformin 500mg prolonged release tablets (JSC Farmak, Ukraine)|DRUG: Glucophage® XR 500 mg prolonged release tablets (Merck Serono Ltd, UK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The 'MADe IT' Clinical Trial: Molecular Analyses Directed Individualized Therapy for Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Vinorelbine|DRUG: Docetaxel|DRUG: Gemcitabine|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of STSP-0601 in Adult Patients With Hemophilia A or B With Inhibitor
Status: COMPLETED
Conditions: Hemophilia
Interventions: DRUG: STSP-0601 for Injection|DRUG: STSP-0601 for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy Versus Sertraline in the Treatment of Post-Traumatic Stress Disorder
Status: TERMINATED
Conditions: Post-Traumatic Stress Disorder
Interventions: DRUG: Sertraline|BEHAVIORAL: Cognitive behavioral therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Socket Reconstruction Technique and Immediate Implant Placement With Two Different Bone Substitute Materials.
Status: NOT_YET_RECRUITING
Conditions: Dental Implant
Interventions: PROCEDURE: Tooth Extraction|PROCEDURE: Immediate Implant Placement|PROCEDURE: Socket reconstruction with DBBB+HA|PROCEDURE: Socket reconstruction with DBBB|PROCEDURE: CTG placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bone Effect of Bortezomib in Patients With Relapsed/Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib (Velcade)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vibration Intervention For Bone Enhancement In Childhood Cancer Survivors
Status: COMPLETED
Conditions: Bone Mineral Density|Bone Strength
Interventions: DEVICE: LMHF mechanical stimulation active device|DEVICE: LMHF mechanical stimulation placebo device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Suicide Risk in Older Veterans Using Problem Solving Therapy
Status: RECRUITING
Conditions: Suicidal Ideation|Depressive Disorder|Anxiety Disorders|Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: Enhanced Usual Care (EUC)|BEHAVIORAL: Problem Solving Therapy (PST) plus EUC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Year 2, Safety Extension Study of the Combination of ABT-335 and Statin Therapy for Subjects With Mixed Dyslipidemia
Status: COMPLETED
Conditions: Mixed Dyslipidemia
Interventions: DRUG: ABT-335|DRUG: rosuvastatin calcium|DRUG: simvastatin|DRUG: atorvastatin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Motor Proficiency in School Age ADHD: Contribution of Different Comorbidities
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder|Comorbidities and Coexisting Conditions|Motor Skills Disorders
Interventions: BEHAVIORAL: Motor Proficiency in School Age ADHD: Contribution of Different Comorbidities
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Carcinoma|Endometrial Clear Cell Adenocarcinoma|Endometrial Serous Adenocarcinoma|Uterine Corpus Cancer|Uterine Corpus Carcinosarcoma
Interventions: DRUG: Metformin Hydrochloride|DRUG: Doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Naltrexone-Bupropion-Methamphetamine Interaction Study
Status: COMPLETED
Conditions: Methamphetamine Dependence
Interventions: OTHER: placebo|DRUG: Naltrexone and Bupropion SR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: This Study Include Chronic Obstructive Pulmonary Disease(COPD) Patients . Patients Were Vitamin D Deficient Age Range 40 to 80 Years, Smokers Patients Were Advised to Take Either Placebo or Vitamin D3 . Antioxidant Enzymes Were Assessed at Baseline and at 26th Weeks.
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: cholecalciferol|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Daunorubicin & Cytarabine +/- Zosuquidar inTreating Older Patients With Newly Diagnosed Acute Myeloid Leukemia or Refractory Anemia
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: sargramostim|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: zosuquidar trihydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2, Randomized, Open-Label Study Of Single Agent CI-1033 In Patients With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Neoplasms
Interventions: DRUG: CI 1033
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Dehydroepiandrosterone Supplementation on Cumulus Cells Gene Expression Under Controlled Ovarian Hyper-stimulation in Patients With Diminished Ovarian Reserve
Status: COMPLETED
Conditions: Dehydroepiandrosterone|DHEAS|Gene Expression of Cumulus Cells.|Ovarian Hyper-stimulation Protocol.|Artificial Reproduction Technology.
Interventions: DRUG: Dehydroepiandrosterone (DHEAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metabolic Syndrome and Insulin Resistance at Allina
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: vitamin D3 (cholecalciferol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective Study of Neoadjuvant Chemotherapy With Gemcitabine/Platinum in Muscle-Invasive or Locally-Advanced Urothelial Carcinoma of Bladder
Status: UNKNOWN
Conditions: Urinary Bladder
Interventions: DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Antiplatelet and Anticoagulation for AIS Patients Witn Concomitant NVAF and Extracranial/Intracranial Artery Stenosis
Status: RECRUITING
Conditions: Acute Ischemic Stroke|Atrial Fibrillation|Stenosis, Carotid|Intracranial Atherosclerosis
Interventions: DRUG: Anticoagulant Oral|DRUG: Anticoagulation combined with antiplatelet therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Artificial Intelligent Based mHealth System to Reduce ACS Patients Bleeding Events After PCI
Status: UNKNOWN
Conditions: Acute Coronary Syndrome|Percutaneous Coronary Intervention|Bleeding
Interventions: BEHAVIORAL: AI based mHealth system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intervention With Vitamin D and Omega-3 Supplements and Incident Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Vitamin D and fish oil|DIETARY_SUPPLEMENT: Fish oil (EPA/DHA) alone|DRUG: Vitamin D alone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The CBD-IC Randomized Controlled Trial: Evaluation of Hemp Cannabidiol SuppositoRies for Pain and Urinary SymptOms in INterstitial Cystitis (CHRONIC)
Status: WITHDRAWN
Conditions: Interstitial Cystitis|Bladder Pain Syndrome
Interventions: DRUG: Cannabidiol vaginal suppository|DRUG: Placebo vaginal suppository
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Immune Checkpoint Inhibitor Therapy on Type 2 Inflammation
Status: COMPLETED
Conditions: Patients Recieving Anti-PD-1 or Anti-PD-L1 Immunotherapies
Interventions: DRUG: Anti-PD-1 or anti-PD-L1
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The ZEro PLASma Trial (ZEPLAST): Avoidance of Fresh Frozen Plasma in Cardiac Surgery
Status: COMPLETED
Conditions: Heart Disease
Interventions: DRUG: Fibrinogen|DRUG: Saline solution|DRUG: Prothrombin complex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1, Dose-Escalation, Pharmacodynamic Study of IV CNF1010 in ZAP-70 Positive CLL
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: CNF1010 (17-AAG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dutch Randomised Endovascular Aneurysm Management (DREAM-) Trial
Status: UNKNOWN
Conditions: Abdominal Aortic Aneurysm
Interventions: PROCEDURE: Open Aneurysm Repair|PROCEDURE: Endovascular Aneurysm Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HIGH Altitude CArdiovascular REsearch in the ANDES
Status: COMPLETED
Conditions: Hypertension|High Altitude
Interventions: DRUG: Telmisartan|DRUG: Nifedipine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Recurrent Primary or Secondary Central Nervous System (CNS) Lymphoma With ALIMTA (Pemetrexed)
Status: COMPLETED
Conditions: Central Nervous System Lymphoma
Interventions: DRUG: pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Radioiodine (131-I) Uptake Following Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal.
Status: COMPLETED
Conditions: Hypothyroidism|Thyroid Neoplasms
Interventions: DRUG: Thyrogen
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation and Importance of the PD-1/PD-L1 and the IL-10/IL-10R Axis in Malignant and Benign Pleural Effusions - a Pilot Study
Status: UNKNOWN
Conditions: Pleural Effusion
Interventions: DIAGNOSTIC_TEST: Pleural effusion will be examined for various cytokines and PD1-lymphocytes.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Digital Based Home Care Service for Ostomy Patients
Status: NOT_YET_RECRUITING
Conditions: Colorectal Neoplasms|Stoma Colostomy|Stoma Ileostomy
Interventions: BEHAVIORAL: The Use of a Mobile Application for Stoma Self-Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Blood Markers of Early Pancreas Cancer
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|PreDiabetes|Pancreas Cyst|Chronic Pancreatitis|Genetic Predisposition to Disease|Inherited Disease
Interventions: DIAGNOSTIC_TEST: Mixed Meal Tolerance Test|DIAGNOSTIC_TEST: Hemoglobin A1c|DIAGNOSTIC_TEST: Other exploratory blood biomarkers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ticagrelol Versus Aspirin in Ischemic Stroke
Status: COMPLETED
Conditions: Acute Stroke|Ischemic Stroke
Interventions: DRUG: Ticagrelor (Brilique) 90|DRUG: Aspirin 75mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Seton or Glue for Trans-sphincteric Anal Fistulas
Status: TERMINATED
Conditions: Anal Fistulas
Interventions: PROCEDURE: transsphincteric Seton positioning|PROCEDURE: glue (Tissucol) treatment|PROCEDURE: Fistula closing with biological glue|PROCEDURE: Seton positioning into the fistula tract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Left Atrial Appendage Closure Compared to Standard Antiplatelet Therapy in Patients With AF Who Underwent PCI
Status: UNKNOWN
Conditions: Myocardial Infarction
Interventions: DEVICE: Left Atrial Appendage Closure Device (Watchman)|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Surgical Intervention for the Treatment of Diabetes in Overweight Non-responders-1
Status: UNKNOWN
Conditions: Overweight|Diabetes Mellitus, Type 2
Interventions: PROCEDURE: Sleeve Gastrectomy with Ileal Transposition|PROCEDURE: Sleeve Gastrectomy with Transit Bipartition|OTHER: Medical Treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p