pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Fentanyl on Coughing and Recovery After Anesthesia With an LMA Laryngeal Mask Airway)for Airway Management
Status: COMPLETED
Conditions: Ambulatory Surgery|Coughing
Interventions: DRUG: Saline|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Metabolic and Appetite Responses to a Whey Protein Preload Following Prior Exercise in Overweight Males
Status: COMPLETED
Conditions: Obesity, Abdominal
Interventions: DIETARY_SUPPLEMENT: Whey protein|OTHER: Mixed macronutrient breakfast meal|OTHER: Ad libitum lunch meal|OTHER: Low/moderate intensity exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess Adverse Events and Effectiveness of HAC 22L Injection for Mid-Face Volume in Adult Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Facial Volume Deficit
Interventions: DEVICE: HAC 22L
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases
Status: RECRUITING
Conditions: Malignant Neoplasm of Bone and Articular Cartilage|Malignant Neoplasms of Female Genital Organs|Malignant Neoplasms of Independent (Primary) Multiple Sites|Malignant Neoplasms of Lip Oral Cavity and Pharynx|Malignant Neoplasm of Male Genital Organs|Malignant Neoplasms of Mesothelial and Soft Tissue|Malignant Neoplasm of Respiratory and Intrathoracic Organ Carcinoma|Malignant Neoplasms of Thyroid and Other Endocrine Glands|Malignant Neoplasms of Urinary Tract|Melanoma and Other Malignant Neoplasms of Skin
Interventions: DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Physical Treatment on Postural Stability in Benign Paroxysmal Positional Vertigo (BPPV) Patients
Status: WITHDRAWN
Conditions: Benign Paroxysmal Positional Vertigo
Interventions: OTHER: Epley maneuver|OTHER: Semont maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Understanding the Measurement of Girdle Dissociation in the Fall of the Older People Subject.
Status: RECRUITING
Conditions: Fall Patients|Frailty
Interventions: DEVICE: Dissociation measure of pelvic and scapular girdles by inertial sensors of accelerometer|DEVICE: GAITRite Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating Two Different Sirolimus-based Immunosuppressive Regimens in Elderly Kidney Transplant Recipients
Status: COMPLETED
Conditions: Kidney Failure|Graft Rejection|Aged
Interventions: DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-finding Study of Abraxane in Combination With Cisplatin to Treat Advanced Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Neoplasms
Interventions: DRUG: ABX + DDP|DRUG: ABX + DDP|DRUG: ABX + DDP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of the Efficacy of CGF and Ozone in the Treatment of Alveolar Osteitis
Status: COMPLETED
Conditions: Alveolar Osteitis
Interventions: DEVICE: Ozone|OTHER: CGF|OTHER: Traditional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Eribulin-Based Regimen Versus Other Chemotherpy in Triple-Negative Metastatic Breast Cancer (ERI-Based-01).
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Eribulin-Based Regimen|DRUG: nab-paclitaxel based regimen|DRUG: Other Chemotherapy Regimen
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics, Safety, and Tolerability of Methylnaltrexone (MNTX) in Subjects With Impaired Renal Function
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Methylnaltrexone (MNTX)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Effects ReSet Your Mind - Mechanisms
Status: COMPLETED
Conditions: Depression Mild|Depression Moderate
Interventions: BEHAVIORAL: Behavioral Activation|BEHAVIORAL: Mindfulness and Gratitude|BEHAVIORAL: Combination of Behavioral Activation and Mindfulness and Gratitude
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Individualized Chemotherapy Based on BRCA1 and RRM1 mRNA for Advanced Non-small Cell Lung Cancer (NSCLC)
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Gemcitabine, Docetaxel, CPT-11,Cisplatin|DRUG: gemcitabine/cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Smartphone Based Telemedicine and Education in Patients With Type 1 Diabetes Mellitus
Status: UNKNOWN
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Experimental : Smartphone-based telemedicine with the app 'Songaree diabetes'
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Friendship Bench Plus Trial
Status: NOT_YET_RECRUITING
Conditions: Major Depressive Disorder|Severe Depressive Episode Without Psychotic Symptoms
Interventions: BEHAVIORAL: Friendship Bench intervention|DRUG: Antidepressants -Fluoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial to Modulate Intermediate Endpoint Biomarkers in Former and Current Smokers
Status: RECRUITING
Conditions: Lung Diseases|Lung Cancer, Protection Against
Interventions: DRUG: Curcumin C3 complex®|DRUG: Lovaza®|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparison of PNF and Task Related Techniques Along With Tens on Upper Limb Function Among Stroke Patients
Status: UNKNOWN
Conditions: Stroke
Interventions: DIAGNOSTIC_TEST: PNF|DIAGNOSTIC_TEST: TRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Pharmacokinetic (PK) Study of NatrOVA Topical Creme (1%) in Pediatric Subjects 6 to 24 Months of Age
Status: COMPLETED
Conditions: Pediculosis Capitis (Head Lice)
Interventions: DRUG: NatrOVA Creme Rinse (1%)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Causal Role of the Aperiodic Signal for Working Memory
Status: RECRUITING
Conditions: Executive Dysfunction
Interventions: DEVICE: Steep-tRAS|DEVICE: Flat-tRAS|DEVICE: Sham-tRAS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long Term Influenza Prophylaxis With Inhaled Zanamivir or Oral Oseltamivir
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: active oseltamivir|DRUG: placebo capsule|DRUG: zanamivir for inhalation|DRUG: placebo for inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ultrasound Guided Pericapsular Nerve Group Block Versus Quadratus Lumborum Block
Status: COMPLETED
Conditions: Pediatric Postoperative Pain
Interventions: PROCEDURE: Quadratus lumborum (QL) block group|PROCEDURE: Pericapsular Nerve Group (PENG) block group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HER-2 Mutations in Tumor Samples From Patients With Advanced Non-Small Cell Lung Cancer Treated on Clinical Trial ECOG-2598
Status: COMPLETED
Conditions: Lung Cancer
Interventions: GENETIC: gene expression analysis|GENETIC: mutation analysis|GENETIC: polymerase chain reaction|OTHER: diagnostic laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Antioxidant Effect of Ozonated Vegetable Oil and Vitamins in Moderately Active Subjects
Status: COMPLETED
Conditions: Oxidative Stress|Inflammation
Interventions: DIETARY_SUPPLEMENT: Ozonized vegetable oil with vitamines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Increasing Children's Defending Behaviors: Using Deviance Regulation
Status: COMPLETED
Conditions: Bullying of Child
Interventions: BEHAVIORAL: DRT Condition|BEHAVIORAL: Empathy Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Improving Sedation of Children Undergoing Procedures in the Emergency Department
Status: COMPLETED
Conditions: Anxiety
Interventions: DRUG: Aerosolized Intranasal midazolam|DRUG: Aerosolized Buccal Midazolam|DRUG: Oral midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preliminary Efficacy and Safety Study of Oral Nepadutant in Infant With Colic Not Responding to Conventional Treatment
Status: WITHDRAWN
Conditions: Infantile Colic
Interventions: DRUG: Nepadutant oral solution|DRUG: Placebo matching Nepadutant oral solution|DRUG: Nepadutant oral solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Empagliflozin 25 mg Film Coated Tablets of Humanis, Turkey and Jardiance (Empagliflozin) 25 mg Film-coated Tablets of Boehringer Ingelheim International GmbH, Germany in Normal, Healthy, Adult, Human Subjects Under Fasting Condition
Status: COMPLETED
Conditions: Type2 Diabetes Mellitus
Interventions: DRUG: Empagliflozin film coated tablets|DRUG: Jardiance film-coated tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Microbiota and Immunoassay in Women With and Without Endometriosis: a Pilot Study
Status: RECRUITING
Conditions: Endometriosis|Endometriosis-related Pain
Interventions: DIAGNOSTIC_TEST: Blood, fecal, vaginal and endometrial liquid samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Tight Glycemic Control During Angioplasty Revascularization Reduces Coronary Stent Restenosis
Status: COMPLETED
Conditions: Restenosis|Tight Glycemic Control
Interventions: DRUG: Insulin|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dasatinib in Combination With Bevacizumab to Treat Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Bevacizumab|DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ovarian Function After Use of Various Hemostatic Techniques During Treatment for Endometrioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometriosis Ovary|Laparoscopy|Ovary; Functional Disturbance|Hemostasis
Interventions: PROCEDURE: Laparoscopic treatment for endometrioma Astus©|DIAGNOSTIC_TEST: AMH Level|DIAGNOSTIC_TEST: Transvaginal ultrasound for antral follicle count|PROCEDURE: Laparoscopic treatment for endometrioma Vicryl®|PROCEDURE: Laparoscopic treatment for endometrioma Surgicel®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal Image Registration for Helping Laparoscopic Liver Surgery Guidance
Status: RECRUITING
Conditions: Hepatectomy|Laparoscopy
Interventions: PROCEDURE: Minimal invasive hepatectomy, intraoperative stage|PROCEDURE: Minimal invasive hepatectomy, postoperative stage|OTHER: Preoperative data collection|OTHER: Intraoperative data collection|OTHER: Postoperative data collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Multiple Micronutrient Fortified Bread Consumption on Iron Deficiency Anemia in Women of Reproductive Age
Status: UNKNOWN
Conditions: Iron Deficiency Anemia
Interventions: OTHER: MULTI-FORTIFIED|OTHER: FORTIFIED
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury
Status: RECRUITING
Conditions: Mild Traumatic Brain Injury|Photophobia
Interventions: DEVICE: Micro Current Neurofeedback Device using Low-Frequency Pulse-Based Transcranial Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Safety and Antibody Response of V212 in Healthy Adults (V212-004)(COMPLETED)
Status: COMPLETED
Conditions: Herpes Zoster
Interventions: BIOLOGICAL: Comparator: V212|BIOLOGICAL: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of CM310 in Subjects With Moderate to Severe Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: CM310|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IV Colistin for Pulmonary Exacerbations: Improving Safety and Efficacy
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Colistin|DRUG: Tobramycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Methodology Trial Using the VR647 Inhalation System in Pediatric Subjects Who Have Previously Received Inhaled Therapy
Status: COMPLETED
Conditions: Cough|Wheezing
Interventions: COMBINATION_PRODUCT: VR647 Inhalation System + VR647 Smart Card 3 Secs|COMBINATION_PRODUCT: VR647 Inhalation System + VR647 Smart Card 2 Secs|COMBINATION_PRODUCT: VR647 Inhalation System + VR647 Smart Card 4 Secs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Trial of SHR-1701 in Combination With and Without Famitinib Malate in Patients With Extensive Stage Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: SHR-1701； Famitinib|DRUG: SHR-1701
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate Efficacy and Safety of ALLO-ASC-DFU in Patients With Diabetic Wagner Grade 2 Foot Ulcers.
Status: RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: BIOLOGICAL: ALLO-ASC-DFU|PROCEDURE: Vehicle Sheet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Effectiveness of Low Vision Rehabilitation in Glaucoma Patients
Status: COMPLETED
Conditions: Glaucoma
Interventions: DEVICE: portable CCTV|DEVICE: Telescopes, telemicroscopes and microscopes|DEVICE: Absorptive filters
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase III Study of TMC435 in Genotype 1, Hepatitis C-infected Participants Who Failed to Respond to Previous IFN-based Therapy
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: TMC435|DRUG: Peginterferon alfa-2a (PegIFNα-2a )|DRUG: Ribavirin (RBV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Tibial Nerve Stimulation in the Treatment of Fecal Incontinence
Status: COMPLETED
Conditions: Fecal Incontinence
Interventions: DEVICE: Urgent PC neuromodulation system|DEVICE: Urgent PC neuromodulation system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Oral Cyclophosphamide and Sirolimus (OCR) in Advanced Sarcoma
Status: COMPLETED
Conditions: Osteosarcoma
Interventions: DRUG: Cyclophosphamide and Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bilateral Dispensing Study of Fanfilcon A Toric Versus Enfilcon A Toric Lenses
Status: COMPLETED
Conditions: Myopia|Hyperopia|Astigmatism
Interventions: DEVICE: fanfilcon A|DEVICE: enfilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Evaluating Safety and Immunogenicity of 10µg/0.5ml Hepatitis B Vaccine
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: 3 dose of 10µg/0.5ml hepatitis B vaccine|BIOLOGICAL: 3 dose of 5µg/0.5ml hepatitis B vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Randomized Controlled Feasibility Trial to Determine the Effectiveness of Set Dancing for People With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: OTHER: Intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post Market Evaluation of Aer-O-Scope Visualization
Status: TERMINATED
Conditions: Cancer
Interventions: DEVICE: Aer-O-Scope (Colonoscopy)|PROCEDURE: Colonoscopy (Conventional Colonoscope)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Remotely Delivered Episodic Future Thinking Intervention to Improve Management of Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Episodic future thinking|BEHAVIORAL: Control Thinking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DNA Tests in Detecting Disseminated Disease in Tumor, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma
Status: COMPLETED
Conditions: Sarcoma
Interventions: GENETIC: DNA methylation analysis|GENETIC: microarray analysis|GENETIC: polymerase chain reaction|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Predict Efficacy by Detecting Circulating Endothelial Cell Subsets and Blood Perfusion Parameters Changes in Vivo Tumor in the Phase II/III Study of Anlotinib in Patients With Advanced Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Anlotinib|DRUG: Placebo Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Evaluating the Safety and Efficacy of Etanercept in Patients With Psoriatic Arthritis Treated by Dermatologists
Status: COMPLETED
Conditions: Arthritis, Psoriatic|Psoriasis|Skin Diseases, Papulosquamous
Interventions: DRUG: etanercept
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Characterization of Neuromuscular Function and Fatigue After Breast Cancer Treated With Adjuvant Chemotherapy (PROTECT-04)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: Characterization of Neuromuscular Function and Fatigue
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Non-intrusive Detection of Temporary Neurologic Impairment By Opioids
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxycodone|DRUG: Placebo|DEVICE: EyeLink 1000 Plus|DIAGNOSTIC_TEST: Oculo-Cognitive Addition test (OCAT)|DEVICE: VT3mini - Eye Tracking Technology for OEMs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Shunt-dependency After aSAH - Role of Early Hyperglycaemia in CSF and Blood
Status: RECRUITING
Conditions: Aneurysm, Ruptured|Hyperglycemia|Hydrocephalus
Interventions: DIAGNOSTIC_TEST: Cerebrospinal Fluid (CSF) Sample|DIAGNOSTIC_TEST: Blood Serum Sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Tamsulosin and/or Dutasteride to Relieve Urinary Symptoms After Brachytherapy for Localized Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: tamsulosin and/or dutasteride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Obturator Block in Lateral Tumors of the Bladder: Does it Have Adverse Effects on Early Postoperative Mobilization?
Status: NOT_YET_RECRUITING
Conditions: Obturator Nerve Block|Ultrasound Guided Nerve Block|Complications Neurological
Interventions: PROCEDURE: spinal block and obturator nerve block
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: B244 Topical Spray for the Treatment of Pruritus in Adults With a History of Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: B244|BIOLOGICAL: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anakinra for COVID-19 Respiratory Symptoms
Status: TERMINATED
Conditions: COVID-19 Infection|ANAKINRA Treatment|Optimized Standard of Care (oSOC)
Interventions: DRUG: Anakinra plus oSOC|DRUG: oSOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Connecting Resources for Urban Sexual Health
Status: COMPLETED
Conditions: HIV|Sexually Transmitted Infections
Interventions: OTHER: Testing and linkage to care for Y/MSM|BEHAVIORAL: Engagement and retention for HIV-positive Y/MSM in care|OTHER: Engagement and retention for HIV-negative Y/MSM in sexual health services|DRUG: Stribild PEP Substudy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The ECLA/PHRI Intervention in the Community Trial
Status: RECRUITING
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Salt substitute 66%33%|DIETARY_SUPPLEMENT: Salt substitute 33%/66%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Research Study Comparing Blood Levels of Medicines NNC0194-0499 and Semaglutide Administered as a Combination Formulation Versus Two Separate Formulations
Status: COMPLETED
Conditions: Non-alcoholic Steatohepatitis
Interventions: DRUG: NNC0194-0499|DRUG: Semaglutide|DRUG: NNC0194-0499/Semaglutide A (40/3.20 mg/mL)|DRUG: NNC0194-0499/Semaglutide A (40/0.33mg/mL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess RAD011 (Cannabidiol Oral Solution) for the Treatment of Participants With Prader-Willi Syndrome
Status: TERMINATED
Conditions: Prader-Willi Syndrome
Interventions: DRUG: RAD011|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigate the Effect of AZD1656 on the Pharmacokinetics and Pharmacodynamics of Warfarin in Type 2 Diabetes Mellitus (T2DM) Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Warfarin|DRUG: Placebo|DRUG: AZD1656
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel and Trastuzumab With or Without Lapatinib in Treating Patients With Stage II or Stage III Breast Cancer That Can Be Removed by Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Male Breast Carcinoma|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7|Stage IIIA Breast Cancer AJCC v7|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Lapatinib Ditosylate|DRUG: Paclitaxel|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Linagliptin on Vascular Inflammation in Patients With Type 2 Diabetes Mellitus
Status: TERMINATED
Conditions: Diabetes Mellitus Type 2 (T2DM)|Vascular Inflammation|Plaque Morphology
Interventions: DRUG: Linagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of ACT-541468 in Elderly Subjects With Insomnia Disorder
Status: COMPLETED
Conditions: Insomnia Disorder
Interventions: DRUG: ACT-541468|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study With GLPG1972 in Osteoarthritis Subjects
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: GLPG1972 cohort 1|DRUG: GLPG1972 cohort 2|DRUG: GLPG1972 cohort 3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Zanubrutinib in the Treatment of Antiphospholipid Syndrome With Secondary Thrombocytopenia
Status: RECRUITING
Conditions: Antiphospholipid Syndrome|Thrombocytopenia|Treatment
Interventions: DRUG: zanubrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of 3D189 in Patients With Hematologic Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Leukemia|Multiple Myeloma|Non-Hodgkin Lymphoma|Higher-risk Myelodysplastic Syndrome
Interventions: BIOLOGICAL: 3D189
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Low Dose Intra-operative Ketamine on Closed-loop Controlled General Anesthesia
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Ketamine Injectable Solution|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of a Cannabinoid Agonist on Colonic Sensory Functions in Patients With Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Dronabinol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Candesartan Cilexetil in Heart Failure Assessment of Reduction in Mortality and Morbidity (CHARM Added)
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: DRUG: Candesartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ixabepilone Before Surgery for High-Risk Localized Prostate Cancer
Status: TERMINATED
Conditions: Prostatic Diseases|Genital Neoplasms, Male|Urogenital Neoplasms|Genital Diseases, Male|Adenocarcinoma|Prostatic Neoplasms|Neoplasms, Glandular and Epithelial|Carcinoma
Interventions: DRUG: Ixabepilone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Precision Medicine to Predict the Trajectory of Liver Cirrhosis: Prospective Cohort Study
Status: RECRUITING
Conditions: Liver Cirrhosis|Metabolic Syndrome|Spleen; Fibrosis|Frailty
Interventions: DIAGNOSTIC_TEST: liver and spleen stiffness test and laboratory test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Photobiomodulation for Breast Cancer Radiodermatitis
Status: COMPLETED
Conditions: Breast Cancer|Radiodermatitis|Radiotherapy Side Effect|Radiation Dermatitis|Radiation Toxicity|Radiation Injuries|Quality of Life|Breast Neoplasms
Interventions: DEVICE: Photobiomodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Tolvaptan For Worsening Outpatient Heart Failure: Role of Copeptin In Identifying Responders
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: DRUG: tolvaptan|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Flamenco (Fitness League Against MENopause COsts) Project
Status: COMPLETED
Conditions: Cardiovascular Diseases|Diabetes|Dyslipidemias|Metabolic Syndrome|Quality of Life
Interventions: BEHAVIORAL: exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Pharmacokinetics and Safety of EXPAREL Administered as a Pectoral Plane Block in Women Undergoing Breast Augmentation
Status: COMPLETED
Conditions: Breast Augmentation
Interventions: DRUG: Exparel Injectable Product|DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimized and Personalized Trans-cranial Brain Stimulation in Partial Refractory Epilepsies
Status: RECRUITING
Conditions: Transcranial Electric Stimulation|tDCS|Epilepsy|Pharmacoresistant|HR EEG|Children
Interventions: OTHER: transcranial electrical stimulation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of the Duration of Bupivacaine Spinal Block in Orthopedic Procedures With and Without Epinephrine Wash
Status: COMPLETED
Conditions: Arthropathy of Hip|Arthropathy of Knee
Interventions: DRUG: Bupivacaine Only|DRUG: EPI25|DRUG: EPI50 group|DRUG: EPI75 group|DRUG: EPI100 group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Prophylactic Prosthesis Placement With Versus Without Omega-3 at the Umbilical Trocar Level on Surgical Site Infection and Herniation After Laparoscopic Cholecystectomy in Patients With Risk Factors.
Status: COMPLETED
Conditions: Surgical Site Infection
Interventions: PROCEDURE: MESH WHIT OMEGA-3|PROCEDURE: MESH WITHOUT OMEGA-3
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Advanced Technology-based Rehabilitation Post-stroke Gait Re-learning
Status: ENROLLING_BY_INVITATION
Conditions: Stroke|Gait Disorders, Neurologic
Interventions: DEVICE: Treadmill training|DEVICE: Overground training|DEVICE: DIERS|OTHER: Traditional physiotherapy assessments
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Combination Therapy of Sintilimab and Chemotherapy With Cryoablation in NSCLC
Status: NOT_YET_RECRUITING
Conditions: Non-Small-Cell Lung Cancer
Interventions: DEVICE: Cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maxillary Sinus Irrigation in the Management of Chronic Rhinosinusitis
Status: COMPLETED
Conditions: Sinusitis
Interventions: PROCEDURE: Maxillary Sinus Irrigation|DRUG: IV Amoxicillin and Clavulanate acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuroprotective Effects of Xenon Treatment in Patients With Cerebral Infarction
Status: NOT_YET_RECRUITING
Conditions: Ischemic Stroke
Interventions: DRUG: Xenon|DRUG: Oxygen 30 %
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EmpowHer is a Gender-specific Teen Pregnancy Prevention Curriculum for Middle School-aged Girls.
Status: RECRUITING
Conditions: Abstinence, Sex
Interventions: BEHAVIORAL: The intervention curriculum addresses sexual activity, abstinence, and adulthood preparation topics.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Medtronic Minimed Overnight Closed-Loop System
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Autoimmune Diabetes|Juvenile-Onset Diabetes|Diabetes, Mellitus, Type 1
Interventions: DEVICE: Hybrid Closed-loop System|DEVICE: Sensor-augmented pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Harnessing Placebo Effects in Methadone Treatment
Status: COMPLETED
Conditions: Opioid-use Disorder|Opioid-Related Disorders
Interventions: BEHAVIORAL: Open-Label Placebo (OLP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Sub-threshold Exercise Treatment for Concussion
Status: WITHDRAWN
Conditions: Concussion, Mild
Interventions: BEHAVIORAL: Aerobic Exercise|BEHAVIORAL: Rest|BEHAVIORAL: Stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 12 / 48 wk Pivotal PFT vs PBO in COPD II
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Olodaterol (BI 1744)|DRUG: Olodaterol (BI 1744)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Validation of the French Version of the Hearing Aid Benefit Measurement COSI and IOI-HA Questionnaires
Status: ACTIVE_NOT_RECRUITING
Conditions: Reproducibility, Internal Consistency, Relevance and Discriminatory Performance of the Tests
Interventions: OTHER: Administration of the French version of the COSI and IOI-HA questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Image-guided Focal Dose Escalation- Primary pc Treated With Primary External Beam Hypofract.Stereotactic rt
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: Radiotherapy (RT) Arm A - IMRT/IGRT/SBRT|RADIATION: Radiotherapy (RT) Arm B - IMRT/IGRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy and Pharmacokinetic Between Capecitabine and Exisulind in Metastatic Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Neoplasms|Metastases, Neoplasm
Interventions: DRUG: Capecitabine|DRUG: Exisulind
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Consumer Preference Study of Two Formulations of Phenylephrine Hydrochloride (Study CL2008-15)(P07530)(COMPLETED)
Status: COMPLETED
Conditions: Vasomotor Rhinitis|Seasonal Allergic Rhinitis
Interventions: DRUG: Phenylephrine Hydrochloride (HCl) Extended Release (ER) Tablets 30 mg|DRUG: Phenylephrine Hydrochloride (HCl) Immediate Release (IR) tablets, 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Carfilzomib and Hyper-CVAD in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoma
Status: COMPLETED
Conditions: Contiguous Stage II Adult Lymphoblastic Lymphoma|Noncontiguous Stage II Adult Lymphoblastic Lymphoma|Stage I Adult Lymphoblastic Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Untreated Adult Acute Lymphoblastic Leukemia
Interventions: DRUG: carfilzomib|DRUG: cyclophosphamide|DRUG: vincristine sulfate|DRUG: doxorubicin hydrochloride|DRUG: dexamethasone|DRUG: methotrexate|DRUG: cytarabine|DRUG: leucovorin calcium|DRUG: methylprednisolone|BIOLOGICAL: rituximab|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Motor Learning Approach for Manual Wheelchair Users
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: BEHAVIORAL: Roller system group (RG)|BEHAVIORAL: Overground group (OG)|BEHAVIORAL: Placebo - Wheelchair skills group (WSG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aortic Valve Replacement With Trifecta(TM)
Status: COMPLETED
Conditions: Aortic Valve Insufficiency|Regurgitation, Aortic Valve|Aortic Valve Incompetence|Aortic Valve Stenosis
Interventions: DEVICE: Trifecta Aortic Heart Valve
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunosuppressive Treatment in Chronic Virus-Negative Inflammatory Cardiomyopathy
Status: RECRUITING
Conditions: Inflammatory Cardiomyopathy
Interventions: DRUG: Mycophenolate Mofetil|DRUG: Prednisolone|DRUG: Mycophenolate Mofetil Placebo|DRUG: Prednisolone Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of an Inactivated SARS-CoV-2 Vaccine for Preventing Against COVID-19 in People Aged ⩾60 Years
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Low dosage Inactivated SARS-CoV-2 Vaccine on a 0- and 28-day schedule|BIOLOGICAL: Medium dosage Inactivated SARS-CoV-2 Vaccine on a 0- and 28-day schedule|BIOLOGICAL: High dosage Inactivated SARS-CoV-2 Vaccine on a 0- and 28-day schedule|BIOLOGICAL: Placebo on a 0- and 28-day schedule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 1 PK Interaction Study Between VX-509 and Prednisone or Methylprednisolone in Healthy Male Subjects
Status: COMPLETED
Conditions: Drug Interactions
Interventions: DRUG: Prednisone|DRUG: VX-509|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Training Model to Advance Support of the Family as a Caregiving System in the Inpatient Oncology Setting
Status: ACTIVE_NOT_RECRUITING
Conditions: Support of the Family as a Caregiving System
Interventions: BEHAVIORAL: Working with the Caregiving Family (WCF) training|BEHAVIORAL: questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Adjuvant Nivolumab Treatment in Stage II (IIA, IIB, IIC) High-risk Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Melanoma Stage II
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity
Status: RECRUITING
Conditions: Chronic Pain|Osteoarthritis, Knee
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Enhancing the Lucentis (Ranibizumab) Management of Choroidal Neovascular Membranes With Hyperspectral Imaging
Status: TERMINATED
Conditions: Macular Degeneration|Choroidal Neovascularization
Interventions: DEVICE: Hyperspectral imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Glenzocimab in SARS-Cov-2 Acute Respiratory DistrEss syNdrome Related to COVID-19
Status: COMPLETED
Conditions: SARS-CoV Infection|Acute Respiratory Distress Syndrome|COVID-19|ARDS
Interventions: DRUG: glenzocimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of Two Intratumoural Doses of Coxsackievirus Type A21 in Melanoma Patients (PSX-X03)
Status: COMPLETED
Conditions: Stage IV Melanoma
Interventions: DRUG: Coxsackievirus A21
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Blood Glucose and Insulin Response After Intake of Vitalose
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DIETARY_SUPPLEMENT: Vitalose|DIETARY_SUPPLEMENT: isomaltulose|DIETARY_SUPPLEMENT: sucrose|DIETARY_SUPPLEMENT: glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Stepping Up: A Trial of Activity Monitoring Devices in Patients Undergoing Autologous Stem Cell Transplant
Status: COMPLETED
Conditions: Multiple Myeloma|Lymphoma|Transplant-Related Disorder
Interventions: BEHAVIORAL: Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Testing the Addition of an Anti-cancer Immune Therapy Drug (Nivolumab) to the Usual Chemotherapy Treatment (Cisplatin or Carboplatin With Gemcitabine) for Recurrent or Metastatic Nasopharyngeal Cancer
Status: TERMINATED
Conditions: Metastatic Nasopharyngeal Carcinoma|Metastatic Nasopharyngeal Keratinizing Squamous Cell Carcinoma|Metastatic Nasopharyngeal Nonkeratinizing Carcinoma|Metastatic Nasopharyngeal Undifferentiated Carcinoma|Nasopharyngeal Nonkeratinizing Carcinoma|Recurrent Nasopharyngeal Carcinoma|Recurrent Nasopharyngeal Keratinizing Squamous Cell Carcinoma|Recurrent Nasopharyngeal Undifferentiated Carcinoma|Stage IV Nasopharyngeal Carcinoma AJCC v8|Stage IVA Nasopharyngeal Carcinoma AJCC v8|Stage IVB Nasopharyngeal Carcinoma AJCC v8
Interventions: DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Gemcitabine|BIOLOGICAL: Nivolumab|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IL-1 Signal Inhibition in Alcoholic Hepatitis
Status: RECRUITING
Conditions: Alcoholic Hepatitis
Interventions: DRUG: Canakinumab 150mg/ml solution for injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of a Short-term Treatment With Canagliflozin (Canacardia-HF)
Status: WITHDRAWN
Conditions: Type2 Diabetes|Heart Failure
Interventions: DRUG: Canagliflozin 100mg|DRUG: Placebo oral capsule|RADIATION: PET imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacokinetics of Paracetamol and Antiepileptic Drugs After Sleeve Gastrectomy
Status: TERMINATED
Conditions: Bariatric Surgery Candidate
Interventions: DRUG: Paracetamol|DRUG: Antiepileptic (either carbamazepine, lamotrigine, phenytoin or valproic acid)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Opicapone as Adjunctive Therapy to Levodopa-Carbidopa Intestinal Gel in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Effect of Drug
Interventions: DRUG: Opicapone 50 mg|DRUG: Duodopa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early vs Delayed Extubation After Endovascular Treatment for Acute Ischemic Stroke
Status: RECRUITING
Conditions: Acute Ischemic Stroke|Endovascular Treatment
Interventions: OTHER: Delayed extubation|OTHER: Early extubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE