pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Toripalimab as Monotherapy for Patients With Small Cell Carcinoma of Esophagus Who Failed Chemotherapy
Status: UNKNOWN
Conditions: Small Cell Carcinoma of Esophagus|Advanced Cancer
Interventions: DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Driving Reduced AIDS-associated Meningo-encephalitis Mortality
Status: COMPLETED
Conditions: AIDS-Related Opportunistic Infections|Meningo-encephalitis|Cryptococcal Meningitis|Bacterial Meningitis|Tuberculous Meningitis|Cerebral Toxoplasmosis
Interventions: OTHER: DREAMM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies
Status: TERMINATED
Conditions: Breast Cancer|Colorectal Cancer|Adenoid Cystic Carcinoma|Non-hodgkin Lymphoma|Glomus Tumor, Malignant|Hepatocellular Carcinoma|Osteosarcoma|T-ALL
Interventions: DRUG: CB-103
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intensity-Modulated Radiation Therapy, Etoposide, and Cyclophosphamide Followed By Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia
Interventions: DRUG: cyclophosphamide|DRUG: etoposide|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: intensity-modulated radiation therapy|RADIATION: tomotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endometrial Markers and Response of Endometriosis Patients to Prolonged GnRH Agonist Prior to IVF
Status: COMPLETED
Conditions: Endometriosis|Infertility
Interventions: DRUG: Leuprolide acetate in depot suspension|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Complementary Food Supplements for Reducing Childhood Undernutrition
Status: COMPLETED
Conditions: Stunting|Wasting
Interventions: DIETARY_SUPPLEMENT: Wheat Soy Blend (WSB++)|DIETARY_SUPPLEMENT: Chickpea based complementary food supplement|DIETARY_SUPPLEMENT: Rice based complementary food supplement|DIETARY_SUPPLEMENT: Plumpy Doz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Supplementation of Land-based Stearidonic Acid (SDA)-Rich Oils in Humans
Status: COMPLETED
Conditions: Hypercholesterolemia|Overweight
Interventions: DIETARY_SUPPLEMENT: Echium oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bioavailability of PRUVIN® and Its Effects in Healthy Subjects (INDIGO)
Status: COMPLETED
Conditions: Oxidative Stress
Interventions: DIETARY_SUPPLEMENT: Pruvin R|OTHER: Isomaltulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Phase II of Zactima Maintenance for Locally Advanced or Metastatic Non-small-cell Lung Carcinoma (NSCLC) Following Platinum-doublet Chemotherapy
Status: COMPLETED
Conditions: NSCLC
Interventions: DRUG: Vandetanib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy With or Without Trastuzumab in Treating Women With Ductal Carcinoma In Situ Who Have Undergone Lumpectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Ductal Carcinoma In Situ
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Trastuzumab|RADIATION: Whole Breast Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyvinkää Childhood Obesity Study (HCOS), Randomized Controlled Clinical Trial for Effectiveness and Costs of a 1-year Lifestyle Intervention.
Status: ACTIVE_NOT_RECRUITING
Conditions: Childhood Obesity
Interventions: PROCEDURE: 1-year dietary and physical activity intervention of childhood obesity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RADx-UP Phase 3D (Oregon Saludable: Juntos Podemos)
Status: RECRUITING
Conditions: Health Behavior|Health Care Utilization|Vaccine Hesitancy
Interventions: BEHAVIORAL: Self-Affirmation Implementation Intentions (SAII) Intervention|BEHAVIORAL: Promotores de Salud (Health Education)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Influence of the Dominance of the Shoulder Stabilized by the Open Latarjet Procedure on the Functional Recovery of the Shoulder at 4.5 Months Postoperatively.
Status: UNKNOWN
Conditions: Latarjet|Shoulder Injuries
Interventions: OTHER: Different exercises with their shoulders|BEHAVIORAL: SI-RSI questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety Surveillance of VaxigripTetra® and Efluelda® Influenza Vaccines in Europe During the Influenza Season 2022/23
Status: COMPLETED
Conditions: Influenza (Healthy Volunteers)
Interventions: BIOLOGICAL: Quadrivalent Influenza Vaccine|BIOLOGICAL: High-Dose Quadrivalent Influenza Vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study on the Safety and Efficacy of Meplazumab for Injection in Severe Patients With COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Meplazumab for injection|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diathermy Compared With Sham Diathermy in Doms Management
Status: TERMINATED
Conditions: Musculoskeletal Diseases
Interventions: DEVICE: Diathermy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peer Approaches to Substances in Early Psychosis Programs: A Pilot Study of a Peer-Led Intervention
Status: NOT_YET_RECRUITING
Conditions: Psychotic Disorders|Substance Use
Interventions: BEHAVIORAL: Invest in My Recovery Bank|BEHAVIORAL: Usual Care Peer Services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Peer-support Exercise Intervention for Older Adults With Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer|Aging
Interventions: BEHAVIORAL: Peer Matching|BEHAVIORAL: Qualified Exercise Professional Support Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Use of Hyperpolarized 129Xe MR Lung Imaging in Adults for Calibration
Status: RECRUITING
Conditions: Respiratory Disorders
Interventions: DRUG: Hyperpolarized 129 Xenon|DEVICE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Selenium Supplementation Among Pediatric Patients With Burns
Status: TERMINATED
Conditions: Burns
Interventions: DRUG: Selenium1|DRUG: Selenium2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oxalate and Citrate
Status: RECRUITING
Conditions: Kidney Stone|Normal Controls
Interventions: OTHER: Kidney stones Normal controls Consuming a special drink (sodium oxalate) during an all day visit to the University of Chicago research clinic
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Daily Goal Setting to Increase Everyday Physical Activity and Promote Cognitive Health in Midlife
Status: ENROLLING_BY_INVITATION
Conditions: Physical Inactivity|Walking|Cognitive Health|Self-regulation|Overweight and Obesity
Interventions: BEHAVIORAL: Adaptive Daily Goal Setting|BEHAVIORAL: Interim Goal Prompt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Direct Renin Inhibition Effects on Atherosclerotic Biomarkers
Status: COMPLETED
Conditions: Coronary Artery Disease|Type 2 Diabetes Mellitus
Interventions: DRUG: Aliskiren|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacology of Cognition in Schizotypal Personality Disorder
Status: TERMINATED
Conditions: Schizotypal Personality Disorder|Personality Disorders
Interventions: DRUG: Guanfacine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Healthy Volunteer Study To Assess Relative Bioavailability Of Powder-In-Capsule And A Tablet Formulation And The Effect Of Food On The Pharmacokinetics Of The Tablet Formulation
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-05175157|DRUG: PF-05175157|DRUG: PF-05175157|DRUG: PF-05175157
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Safety and Efficacy of Insulin Glargine + Glulisine or Insulin Regular + NPH Insulin (Isophane Insulin) Use in Type 2 Diabetes Mellitus Patients With Moderate Renal Failure.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: INSULIN GLARGINE|DRUG: NPH insulin (insulin isophane)|DRUG: INSULIN GLULISINE|DRUG: Regular insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Clinical Trial to Explore Systemic Exposure of CTO0101 Eye Drops, Safety and Local Tolerability in Healthy Adults
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: CTO0101|OTHER: Placebo (vehicle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assesment the Efficacy of Dd-cfDNA in Routine Patient Care in Kidney Transplant Recipients"
Status: NOT_YET_RECRUITING
Conditions: Renal Transplantation
Interventions: BIOLOGICAL: dd-cfDNA-guided
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluate the Safety, Tolerability of BAT6026
Status: RECRUITING
Conditions: Dermatitis, Atopic
Interventions: DRUG: Monoclonal antibody BAT6026|DRUG: sodium chloride injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Trial of IW-1973, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Stable Type 2 Diabetes and Hypertension
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Hypertension
Interventions: DRUG: Matching Placebo|DRUG: IW-1973
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to See Whether Two HIV Vaccines Are Safe and Can Prevent HIV Infection
Status: COMPLETED
Conditions: HIV Infections|HIV Seronegativity
Interventions: BIOLOGICAL: gp160 MN/LAI-2|BIOLOGICAL: ALVAC-HIV MN120TMG (vCP205)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: TAP vs. ESP Block for Gynecological Post Operative Pain
Status: COMPLETED
Conditions: Nerve Block|Pain, Postoperative
Interventions: PROCEDURE: Transversus Abdominis Plane Block using 0.25% Bupivacaine|PROCEDURE: Erector Spinae Plane Block using 0.25% Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (The COAPT Trial) and COAPT CAS
Status: ACTIVE_NOT_RECRUITING
Conditions: Mitral Regurgitation|Mitral Valve Regurgitation|Treatment of Functional Mitral Regurgitation in Symptomatic Heart Failure Subjects|Heart Failure
Interventions: DEVICE: MitraClip System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Breast Cancer|Leptomeningeal Disease
Interventions: DRUG: Tucatinib|DRUG: Trastuzumab|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing Symptomatic Clinical Episodes in Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: AXS-05|DRUG: Bupropion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lanifibranor in Patients With Type 2 Diabetes & Nonalcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Nonalcoholic Fatty Liver Disease (NAFLD)|Type 2 Diabetes (T2DM)
Interventions: DRUG: Lanifibranor|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GVAX Pancreas Vaccine (With CY) in Combination With Nivolumab and SBRT for Patients With Borderline Resectable Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Cyclophosphamide|DRUG: Nivolumab|DRUG: GVAX Pancreas Vaccine|RADIATION: Stereotactic Body Radiation (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis.
Status: NOT_YET_RECRUITING
Conditions: Infective Endocarditis
Interventions: DIAGNOSTIC_TEST: CBCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Role of Dietary Fat on Postprandial Endotoxemia in Healthy Adults
Status: COMPLETED
Conditions: Endotoxemia
Interventions: OTHER: Low-fat Treatment Meal|OTHER: Saturated-fat Treatment Meal|OTHER: N-3 fat Treatment Meal|OTHER: N-6 fat Treatment Meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: SMart Angioplasty Research Team: CHoice of Optimal Anti-Thrombotic Strategy in Patients Undergoing Implantation of Coronary Drug-Eluting Stents 3
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DRUG: Aspirin|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tryptase and Coronary Heart Disease
Status: COMPLETED
Conditions: Acute Coronary Syndrome With ST Elevation on Electrocardiogram|Acute Coronary Syndrome Without ST Elevation on Electrocardiogram|Noncritical Coronary Artery Disease Coronary Stenosis Less Than 50 Per Cent|Aortic Aneurysms
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Prevalence of anomalIes of Glucose Metabolism in Patients Undergoing a Coronary Artery Bypass Graft (CABG)
Status: COMPLETED
Conditions: Anomalies in Glucose Metabolism|Coronary Artery Bypass Graft
Interventions: OTHER: Collection of biological data|OTHER: Collection of clinical data
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: AZD1775 in Treating Patients With Advanced Refractory Solid Tumors With CCNE1 Amplification
Status: COMPLETED
Conditions: Advanced Malignant Solid Neoplasm|Refractory Malignant Solid Neoplasm
Interventions: DRUG: Adavosertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Function and Morphological Characteristics of Meibomian Gland in Patients With Renal Anemia
Status: RECRUITING
Conditions: Dry Eye|MGD-Meibomian Gland Dysfunction
Interventions: DIAGNOSTIC_TEST: Dry eye examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Early Mineralocorticoid Receptor Antagonist Treatment to Reduce Myocardial Infarct Size
Status: COMPLETED
Conditions: ST-elevation Myocardial Infarction
Interventions: DRUG: Mineralocorticoid receptor antagonist potassium-canrenoate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective triAl of Modified Treat-and-extend Regimens With BroLucizumab in pachychOroid Neovasculopathy
Status: NOT_YET_RECRUITING
Conditions: Age-Related Macular Degeneration|Pachychoroid Neovasculopathy
Interventions: DRUG: Brolucizumab Injection [Beovu]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)
Status: RECRUITING
Conditions: Essential Thrombocythemia
Interventions: DRUG: Bomedemstat|DRUG: Anagrelide|DRUG: Busulfan|DRUG: Interferon alfa/pegylated interferon alfa|DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of MBX-2982 Administered Daily for 4 Weeks as Monotherapy in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: MBX-2982|DRUG: MBX-2982|DRUG: MBX-2982|DRUG: Sitagliptin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Responsible Engaged and Loving (REAL) Fathers Intervention Evaluation
Status: RECRUITING
Conditions: Violence, Gender-Based|Violence, Domestic|Violence, Sexual|Violence, Physical|Contraception Behavior|Child Development|Child Abuse|Communication, Partner|Conflict Resolution|Parent-Child Relations
Interventions: BEHAVIORAL: Responsible Engaged and Loving (REAL) Fathers Initiative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Preoperative Erector Spinae Plane Block Versus Paravertebral Plane Block in Decreasing Post Mastectomy Pain Syndrome
Status: NOT_YET_RECRUITING
Conditions: Chronic Postoperative Pain
Interventions: PROCEDURE: Paravertebral plane block|PROCEDURE: Erector spinae plane block|DRUG: Intravenous morphine, ketorlac and paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase I Study of Lapatinib (Tykerb) Plus Ixabepilone (Ixempra) as 2nd-line Treatment for Patients With HER-2 Overexpressed Recurrent or Persistent Endometrial Carcinoma or Carcinosarcoma
Status: UNKNOWN
Conditions: Recurrent Endometrial Cancer
Interventions: DRUG: Lapatinib and ixempra
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Acute Respiratory Distress Syndrome With Tenecteplase: A Dose Escalation Pilot Study
Status: WITHDRAWN
Conditions: Acute Respiratory Distress Syndrome
Interventions: DRUG: Tenecteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neo-Adjuvant Chemotherapy and Conservative Surgery in Cervical Cancer to Preserve Fertility
Status: TERMINATED
Conditions: Cervical Cancer
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|PROCEDURE: conisation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trail of Iodine[131I] Metuximab Injection With CIK Cells for Preventing Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Multiple Drug Use
Interventions: BIOLOGICAL: Licartin and CIK
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Excessive Weight Gain in Adolescent Girls at High-Risk for Adult Obesity
Status: COMPLETED
Conditions: Obesity|Overweight|Binge Eating
Interventions: BEHAVIORAL: Interpersonal Psychotherapy|BEHAVIORAL: Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A More Physiological Feeding Process in ICU:the Intermittent Infusion With Semi-solidification of Nutrients
Status: COMPLETED
Conditions: Nutrition, Enteral
Interventions: DIETARY_SUPPLEMENT: semi-solid agent with standard enteral feeding|OTHER: standard enteral feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate Efficacy and Safety of Inhaled BEA 2180 BR in COPD Patients
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: BEA 2180 BR|DRUG: Tiotropium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Nitrous Oxide 50% for Reducing Pain And Distress Associated With Needle-stick in Children
Status: WITHDRAWN
Conditions: Local Anesthetic Efficacy
Interventions: DRUG: Local Anesthetics,Topical|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sodium Stibogluconate and IFNa-2b Followed By CDDP, VLB and DTIC Treating Pts.With Advanced Melanoma or Other Cancers
Status: COMPLETED
Conditions: Stage IV Melanoma
Interventions: BIOLOGICAL: recombinant interferon alfa-2b|DRUG: cisplatin|DRUG: sodium stibogluconate|DRUG: dacarbazine|DRUG: vinblastine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CLL1-CD33 cCAR in Patients With Relapsed and/or Refractory, High Risk Hematologic Malignancies
Status: UNKNOWN
Conditions: Hematologic Malignancy|Acute Myeloid Leukemia|Myelodysplastic Syndromes|Myeloproliferative Neoplasm|Chronic Myeloid Leukemia
Interventions: BIOLOGICAL: CLL1-CD33 cCAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Fruquintinib Combined With Tegafur Gimeracil Oteracil in Patients With Metastatic Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastasis Colorectal Cancer|Colon Cancer|Rectal Cancer
Interventions: DRUG: Fuquinitinib+Tegafur Gimeracil Oteracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of 2 Different Nevirapine Extended Release Formulations Compared to Viramune® in HIV-1 Infected Subjects
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: NVP XR 400 mg (KCR 25%)|DRUG: NVP XR 400 mg (KCR 20%)|DRUG: NVP XR 300 mg (KCR 25%)|DRUG: NVP XR 300 mg (KCR 20%)|OTHER: high-fat breakfast|DRUG: NVP IR 200 mg (Viramune®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab in Combination With AMG 479 in HER-2 Overexpressing MBC Progressing on Trastuzumab
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: AMG 479|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Heterotopic Fresh Ovarian Graft in Woman With LACC Eligible for Pelvic Radiotherapy Treatment.
Status: RECRUITING
Conditions: Locally Advanced Cervical Carcinoma|Premature Ovarian Failure
Interventions: PROCEDURE: Ovarian graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Methadone in Newborn Infants
Status: COMPLETED
Conditions: Premature Birth of Newborn|Critically Ill
Interventions: DRUG: Methadone|DRUG: Methadone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pyrotinib Combined With Trastuzumab and Chemotherapy Neoadjuvant Therapy for HER2-positive Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer Female
Interventions: DRUG: Pyrotinib and Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate the Efficacy and Safety Of Atezolizumab or Placebo in Combination With Neoadjuvant Doxorubicin + Cyclophosphamide Followed By Paclitaxel + Trastuzumab + Pertuzumab In Early Her2-Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Atezolizumab|DRUG: Placebo|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Paclitaxel|DRUG: Trastuzumab|DRUG: Pertuzumab|DRUG: Trastuzumab Emtansine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Adolescent Vaccination in the Medical Home: Established and Innovative Strategies
Status: COMPLETED
Conditions: Immunization Rate
Interventions: BEHAVIORAL: Text Message Reminder/Recall|BEHAVIORAL: Parent Preference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Long Term Safety and Efficacy Study of Calcitriol 3 mcg/g Ointment in Pediatric Subjects With Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: Calcitriol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Tobramycin in BPD
Status: ACTIVE_NOT_RECRUITING
Conditions: Bronchopulmonary Dysplasia
Interventions: DRUG: Tobramycin solution for inhalation 78mg dose|DRUG: Tobramycin solution for inhalation 150mg dose|DRUG: Tobramycin solution for inhalation 216mg dose|DRUG: Tobramycin solution for inhalation 300mg dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanistic Evaluation on Sorafenib Induced Hypophosphatemia.
Status: TERMINATED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Sorafenib (Nexavar, BAY43-9006)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Well-Being Promotion Program for Management of Emotional and Behavioural Problems Among Adolescents
Status: RECRUITING
Conditions: Well-being, Emotional and Behavioral Problems, Adolescents
Interventions: OTHER: Well-Being Promotion Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Early Detection Initiative for Pancreatic Cancer
Status: ENROLLING_BY_INVITATION
Conditions: Hyperglycemia|Diabetes Mellitus|Pancreas Ductal Adenocarcinoma
Interventions: OTHER: Enriching New-onset Diabetes for Pancreatic Cancer (ENDPAC) score|OTHER: Abdominal imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Immune Response to Pneumococcal Polysaccharide Vaccine (23-valent) Predicts Asthma Status and Outcomes in Late Adolescents With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: Pneumonococcal Polysaccharide Vaccine 23-valent (PPSV-23)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cost-Effectiveness Study of PEG-rhG-CSF in Prophylactic Treatment of Neutropenia After Chemotherapy in Lymphoma
Status: UNKNOWN
Conditions: Lymphoma, Non-Hodgkin|Granulocyte Colony-Stimulating Factor|Cost-Benefit Analysis
Interventions: DRUG: PEG-rhG-CSF|DRUG: rhG-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Manual Therapy and Sacroiliac Joint Injection in Sacroiliac Joint Dysfunction
Status: COMPLETED
Conditions: Sacroiliac Joint Somatic Dysfunction
Interventions: OTHER: Manuel therapy|OTHER: Sacroiliac joint injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Efficacy of Ketamine and Propofol Mixture With 1:6 Ratio and 1:4 Ratio for Endoscopic Retrograde Procedure Sedation
Status: COMPLETED
Conditions: Adult Patients Undergoing ERCP
Interventions: DRUG: ketamine and propofol mixture with 1:6 ratio|DRUG: ketamine and propofol mixture with 1:4 ratio
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Correlation Between Sedation Depth Monitoring and Reflexes During Intravenous Anesthesia With Dexmedetomidine and Remifentanil in Children Undergoing Direct Laryngoscopy for Surgical Procedures
Status: RECRUITING
Conditions: Laryngoscopy|Child|Monitoring
Interventions: DEVICE: NeuroSENSE ®in children
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Predicting the Quality of Response to Specific Treatments in Patients With cGVHD, PQRST Study
Status: RECRUITING
Conditions: Chronic Graft Versus Host Disease
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Medical Chart Review|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Different Exercise Programs for People With Chronic Whiplash Associated Disorders
Status: COMPLETED
Conditions: Whiplash
Interventions: OTHER: Neck Specific Exercises|BEHAVIORAL: Behavioral approach combined with neck specific exercises|OTHER: Prescribed Physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AngioSculpt Scoring Balloon Catheter For Bifurcation Coronary Lesions (ABC Study)
Status: TERMINATED
Conditions: Bifurcation Coronary Disease
Interventions: DEVICE: AngioSculpt
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantifying Effects of Treatment of Pediatric Dysphonia
Status: TERMINATED
Conditions: Voice Disorders|Gastroesophageal Reflux
Interventions: BEHAVIORAL: Neuromuscular Electrical Stimulation|BEHAVIORAL: Unstimulated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Actigraphy Procedures on the Initiation of an Apomorphine Treatment Delivered Through a Pump to Patients With Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: DEVICE: Actimetry measures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders
Status: RECRUITING
Conditions: Langerhan's Cell Histiocytosis|Juvenile Xanthogranuloma|Erdheim-Chester Disease|Rosai Dorfman Disease|Neuro-Degenerative Disease|Histiocytic Sarcoma|Histiocytic Disorders, Malignant
Interventions: DRUG: Cobimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Acu-Transcutaneous Electrical Nerve Stimulation (Acu-TENS) on Post-exercise Expiratory Flow Volume in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Acu-TENS|DEVICE: Placebo-TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Ondansetron in LARS Treatment
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DRUG: Ondansetron 4 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preemptive and Preventive Use of Paracetamol for Pain Relief After Cesarean Section
Status: COMPLETED
Conditions: Cesarean Section; Dehiscence
Interventions: DRUG: Paracetamol was given intravenously in both group at different times
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Sugammadex-dosing in Bariatric Patients
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: DRUG: ideal BW based sugammadex reversal of moderate block|DRUG: real body weight based sugammadex reversal of moderate block|DRUG: real body weight based sugammadex reversal of deep block|DRUG: ideal body weight based sugammadex reversal of deep block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab Plus Standard Dose Bevacizumab Versus Nivolumab Plus Low Dose Bevacizumab in GBM
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: Nivolumab|DRUG: Standard Dose Bevacizumab|DRUG: Low Dose Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Dorner Tablets and Aspirin for Prevention of Arteriosclerosis Progress in Type 2 Diabetes Mellitus Patients
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Beraprost|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vascular Changes of Rotator Cuff Repair Augmented With a Whole Blood Fibrin Clot
Status: COMPLETED
Conditions: Rotator Cuff Tear
Interventions: OTHER: Whole Blood Fibrin Clot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Efficacy and Safety of Nemolizumab (CD14152) in Participants With Prurigo Nodularis (PN)
Status: COMPLETED
Conditions: Prurigo Nodularis
Interventions: DRUG: Nemolizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Liraglutide Formulations in Healthy Subjects
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: liraglutide|DRUG: liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Pregnancy-associated Malaria in HIV-infected Women: Cotrimoxazole Prophylaxis Versus Mefloquine
Status: COMPLETED
Conditions: Malaria in Pregnancy|HIV Infections
Interventions: DRUG: cotrimoxazole|DRUG: mefloquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Non-randomized Safety Study With Bortezomib/Rituximab in Relapsed/Refractory Indolent Lymphoma
Status: COMPLETED
Conditions: Lymphoma|Non-Hodgkin Lymphoma
Interventions: DRUG: Rituximab|DRUG: VELCADE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cabozantinib and Dostarlimab in Recurrent Gynecologic Carcinosarcoma
Status: RECRUITING
Conditions: Gynecologic Cancer|Carcinoma|Uterine Cancer|Endometrial Cancer
Interventions: DRUG: Cabo + Dostarlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Technology Assisted Behavioral Intervention in Assisting People With Major Depressive Disorder
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Behavioral intervention (iCBT + TeleCoach)|BEHAVIORAL: Internet-based cognitive behavioral therapy (I-CBT)|BEHAVIORAL: Treatment as usual / Wait-list control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nutraceutical Supplement in the Management of Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Cardiopressin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Sealants and Fluoride Varnish in Caries Prevention in Children With Autism Spectrum Disorders
Status: COMPLETED
Conditions: Autistic Disorder|Dental Caries|Pit and Fissure Caries
Interventions: PROCEDURE: Fluoride varnish and pit and fissure sealants onto first permanent molars
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Diabetes Disparities: Texting to Extend Treatment (DD-TXT)
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Intervention 1- DD-TXT|BEHAVIORAL: Comparison - DSE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Monoclonal Antibody ABX-EGF in Treating Patients With Renal (Kidney), Prostate, Pancreatic, Non-Small Cell Lung, Colon or Rectal, Esophageal, or Gastroesophageal Junction Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Esophageal Cancer|Kidney Cancer|Lung Cancer|Pancreatic Cancer|Prostate Cancer
Interventions: BIOLOGICAL: panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Telephone Follow-up With In-person Follow-up After Medical Abortion
Status: COMPLETED
Conditions: Medical; Abortion, Fetus
Interventions: OTHER: Remote Follow-up (RFU)|OTHER: Standard Follow-up (SFU)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: IBI376 in Patients With Relapsed or Refractory Follicular Lymphoma/Marginal Zone Lymphoma
Status: COMPLETED
Conditions: Indolent Non-hodgkin Lymphoma
Interventions: DRUG: IBI376
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PAC-IC-SAOS Obstructive Sleep Apnea Syndrome and Ventricular Function
Status: COMPLETED
Conditions: Heart Failure|Arteriosclerosis of Coronary Artery Bypass Graft or Other Coronary Reperfusion|Sleep Apnea, Obstructive
Interventions: PROCEDURE: CPAP treatment|OTHER: Sham CPAP treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glecaprevir/Pibrentasvir for Post-traumatic Stress Disorder
Status: NOT_YET_RECRUITING
Conditions: PTSD
Interventions: DRUG: Glecaprevir/pibrentasvir|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality and Robot Assisted Gait Training in Patients With Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: DEVICE: Robot-assisted gait training group+VR|DEVICE: GEO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The TRUST Study - Depression Substudy
Status: COMPLETED
Conditions: Subclinical Hypothyroidism|Depression
Interventions: DRUG: Levothyroxine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Glucosamine-study: The Effect of Glucosamine in Treatment of Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: Glucosamine sulphate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin and Unsaturated Fatty Acid Supplements in Healthy and Uveitis Human Subjects
Status: RECRUITING
Conditions: Healthy|Uveitis|Autoimmune Diseases
Interventions: DIETARY_SUPPLEMENT: Vitamin A treatment|DIETARY_SUPPLEMENT: Monounsaturated fatty acid mixture|DIETARY_SUPPLEMENT: Polyunsaturated fatty acid mixture|DIETARY_SUPPLEMENT: Fatty acid mixture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Two Flaps for Root Coverage
Status: COMPLETED
Conditions: Gingival Recession
Interventions: PROCEDURE: CAF plus connective tissue graft|PROCEDURE: Tunnel plus connective tissue graft|DRUG: Sodium dipyrone|DRUG: chlorhexidine rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of a Raltegravir Based NRTI Sparing Regimen
Status: COMPLETED
Conditions: Acquired Immune Deficiency Syndrome|AIDS|Human Immunodeficiency Virus|HIV Infections
Interventions: DRUG: Raltegravir|DRUG: Atazanavir|OTHER: Standard treatment regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DORADO-AC - Optimized Doses of Darusentan as Compared to an Active Control in Resistant Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Darusentan|DRUG: Guanfacine|DRUG: Darusentan Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Motilin on the Frequency and Amount of Food Intake
Status: ENROLLING_BY_INVITATION
Conditions: Healthy|Obesity
Interventions: DRUG: Erythromycin|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of Different Types of Toothbrushes on Periodontal Health in Orthodontic Patients
Status: COMPLETED
Conditions: Gingivitis|Orthodontics
Interventions: OTHER: Toothbrushing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Anti-factor Xa Based Venous Thromboembolism Prophylaxis
Status: COMPLETED
Conditions: Dose Adjustment of Enoxaparin in ICU Patients
Interventions: OTHER: Dose adjustment of Enoxaparin in patients with sub-therapuetic (prophylactic) levels of factor 10a
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of SPN-812 (Viloxazine Extended-release Capsule) in Adults With ADHD
Status: COMPLETED
Conditions: Attention-Deficit/Hyperactivity Disorder (ADHD)
Interventions: DRUG: Placebo|DRUG: SPN-812
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Co-administration Study of OCV, TCV and MR
Status: NOT_YET_RECRUITING
Conditions: Typhoid|Cholera|Measles|Rubella
Interventions: BIOLOGICAL: Oral Cholera Vaccine (OCV)|BIOLOGICAL: Typhoid Conjugate Vaccine (TCV)|BIOLOGICAL: Measles and Rubella (MR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION