pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Does the Addition of Manual Therapy Techniques Increase Gastrocnemius/Soleus Length More Than Stretching Alone?
Status: COMPLETED
Conditions: Muscle Tightness
Interventions: PROCEDURE: Instrument Assisted Soft Tissue Mobilization|PROCEDURE: Rearfoot joint mobilization|OTHER: Static stretching/ROM exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Switching to E-cigarettes in African-American Smokers
Status: RECRUITING
Conditions: Smoking Reduction
Interventions: DRUG: Varenicline Tartrate|DRUG: Placebo|OTHER: Electronic cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Gut Microbiota Analysis of an Oral Microbiotherapy in Patients With Amyotrophic Lateral Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis|ALS
Interventions: DRUG: MaaT033
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Treatment of the Intervertebral Disc More Effective at Short-term Than the Nerve Root in Patients With a Neck Hernia?
Status: UNKNOWN
Conditions: Contained Cervical Disc Herniation
Interventions: PROCEDURE: Percutaneous Cervical Nucleoplasty|PROCEDURE: Pulsed Radio Frequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Physical Activity and Cardiac Rehabilitation Attendance Using Technology and Behavioral Economics
Status: WITHDRAWN
Conditions: Cardiovascular Diseases
Interventions: BEHAVIORAL: Gamification|BEHAVIORAL: Loss-Framed Financial Incentives
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Mode of Action of Moviprep
Status: COMPLETED
Conditions: Functional Constipation|Irritable Bowel Syndrome Characterized by Constipation
Interventions: DRUG: Polyethyleneglycol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of PAN-90806 Eye Drops, Suspension for Neovascular AMD
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: PAN-90806 Ophthalmic Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Synergistic Effect Of Parenteral Diclofenac And Paracetamol In The Pain Management Of Acute Limb Injuries
Status: COMPLETED
Conditions: Musculoskeletal Injury
Interventions: DRUG: Diclofenac and Paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Timing Carotid Stent Clinical Study for the Treatment of Carotid Artery Stenosis（Timing Trial）
Status: RECRUITING
Conditions: Carotid Artery Diseases|Carotid Artery Stenosis|Stroke|Ischemic Stroke
Interventions: DEVICE: Timing Carotid Stent|DEVICE: Carotid Wallstent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Compare the Pharmacokinetics of TAH Tablet in Comparison to the Co-administration of Telmisartan, Amlodipine and Hydrochlorothiazide in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: TAH Tablet (Telmisartan/Amlodipine besylate/Hydrochlorothiazide)|DRUG: TWYNSTA(Telmisartan+Amlodipine besylate)|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enteral Levetiracetam For Seizure Control In Pediatric Cerebral Malaria
Status: COMPLETED
Conditions: Seizure|Epilepsy|Cerebral Malaria
Interventions: DRUG: LEVETIRACETAM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Feasibility of Motivational Interviewing on Emotional Authenticity, Dispositional Optimism, And Academic Motivation Among Nursing Students: A Randomized Controlled Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Nursing Students
Interventions: BEHAVIORAL: Motivational Interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Project MiNT: Assessing the Impact of Food & Video-Based Nutrition Education on Patients With Poorly Controlled Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Medically Tailored Meals|BEHAVIORAL: Tele-Medical Nutrition Therapy (tele-MNT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Memantine for the Treatment of Cognitive Impairment in Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: Lupus Erythematosus, Systemic
Interventions: DRUG: Memantine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hemodialysis in the Elderly (70yrs & Older)
Status: RECRUITING
Conditions: Kidney Disease|Kidney Failure|Chronic Kidney Disease
Interventions: PROCEDURE: Surgical fistula creation from patient's anatomy|DEVICE: Surgical Graft implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Methylcellulose or Psyllium on Fermentation of inUlin Assessed USing MRI
Status: COMPLETED
Conditions: Colon, Irritable
Interventions: DIETARY_SUPPLEMENT: Psyllium|DIETARY_SUPPLEMENT: Methylcellulose|DIETARY_SUPPLEMENT: Inulin|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PSUNRISE - Prospective Study Using Remicade in Psoriasis Patients With an Inadequate Response to Etanercept
Status: COMPLETED
Conditions: Psoriasis
Interventions: BIOLOGICAL: infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cellular & Biocellular Regenerative Therapy in Musculoskeletal Pain, Dysfunction,Degenerative or Inflammatory Disease
Status: UNKNOWN
Conditions: Osteoarthritis|Rheumatoid Nodule|Degenerative Joint Disease|Tendinopathy|Tendinosis|Back Pain
Interventions: DRUG: Normal Saline|PROCEDURE: Tissue Stromal Vascular Fraction|BIOLOGICAL: Platelet Rich Plasma|PROCEDURE: Cellular Stromal Vascular Fraction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Crystalloid Cardioplegia and HTK Solution for Postoperative Troponin-I and CK-MB Levels After Pediatric Cardiac Surgery
Status: UNKNOWN
Conditions: Myocardial Injury
Interventions: DRUG: HTK solution|DRUG: crystalloid cardioplegia solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Medium Term Health Coaching and Life-long Monitoring in Cardiovascular Disease in Norrbotten
Status: COMPLETED
Conditions: Diabetes|Heart Disease|Quality of Life
Interventions: PROCEDURE: Health Coaching and Life-long Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intermittent Multifunctional Nutrition Tube in Cerebral Palsy and Dysphagia
Status: NOT_YET_RECRUITING
Conditions: Cerebral Palsy
Interventions: BEHAVIORAL: systemic therapy|DEVICE: Intermittent Oro-Esophageal Tube Feeding|DEVICE: Persistent Nasogastric Tube Feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Exosomes Overexpressing CD24 to Prevent Clinical Deterioration in Patients With Moderate or Severe COVID-19 Infection
Status: UNKNOWN
Conditions: COVID-19 Disease
Interventions: DRUG: Exosomes overexpressing CD24
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Induction Chemotherapy Before Surgery in Operable Non-small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: gemcitabine, cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deciphering the Vitiligo Transcriptomic Signature Between Repigmented and Non Repigmented Lesions
Status: RECRUITING
Conditions: Vitiligo
Interventions: PROCEDURE: SKIN SAMPLES|PROCEDURE: BLOOD SAMPLES|DEVICE: narrowband UVB|DRUG: Systemic Steroids
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Tipifarnib and Sorafenib Tosylate in Treating Patients With Biopsiable Advanced Cancer
Status: COMPLETED
Conditions: Advanced Malignant Neoplasm
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Sorafenib Tosylate|DRUG: Tipifarnib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate a 13-valent Pneumococcal Conjugate Vaccine in Elderly Subjects
Status: COMPLETED
Conditions: Vaccines, Pneumococcal Conjugate Vaccine
Interventions: BIOLOGICAL: 13-valent Pneumococcal Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Gum® HydralTM Moisturizing Gel and Biotene® Oral Gel in Dry Mouth Sensation Reduction
Status: COMPLETED
Conditions: Xerostomia
Interventions: DRUG: Betaine taurine PVP gel|DRUG: Xylitol, Lactoperoxidase, Lysozyme, Lactoferrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Paclitaxel Coated Balloon Catheter for Prevention of Restenosis in Femoropopliteal Arteries
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: paclitaxel coated balloon catheter (device with drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Sintilimab Combined With Concurrent Chemoradiation Therapy in Locally Advanced Cervical Cancer
Status: UNKNOWN
Conditions: Uterine Cervical Neoplasms|Sintilimab
Interventions: DRUG: Sintilimab|DRUG: Cisplatin|RADIATION: External Beam Radiotherapy (EBRT)|RADIATION: brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RSA-Study of Cemented Hip Prostheses With Five Different Articulations
Status: UNKNOWN
Conditions: Arthritis
Interventions: DEVICE: charnley OGEE|DEVICE: Spectron Reflection CoCr|DEVICE: Spectron XLPE CoCr|DEVICE: Spectron Reflection Oxinium|DEVICE: Spectron XLPE CoCR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Impact of a Personal and Domestic Hygiene Intervention on Lead Exposure in a Community Close to a Mine Dump
Status: UNKNOWN
Conditions: Lead Poisoning|Lead Poison Children
Interventions: BEHAVIORAL: Domestic Hygiene and household hygiene Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy, Tolerability and Safety of Intravenous D-VC With ATO in Patients With Advanced/Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer|Metastatic Colorectal Cancer
Interventions: COMBINATION_PRODUCT: D-isoascorbic Acid (D-VC) With Arsenic Trioxide (ATO)|DRUG: FOLFOX/FOLFIRI regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Web Intervention for Parents of Youth With Genetic Syndromes (WINGS)
Status: RECRUITING
Conditions: Telomeric 22Q13 Monosomy Syndrome|Tuberous Sclerosis|Hamartoma Syndrome, Multiple|Fragile X Syndrome|Angelman Syndrome|Rett Syndrome|Chromosome 15Q, Partial Deletion|Creatine Deficiency, X-linked
Interventions: BEHAVIORAL: Functional Behavioral Training (FBT)|OTHER: Positive Parenting Strategies-Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Intravenous Glassia® Treatment in Lung Transplantation
Status: COMPLETED
Conditions: Transplantation, Lung Rejection
Interventions: DRUG: GLASSIA® and Institution standard of care (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nitrates and Bone Turnover; Nitrates and Bone Turnover Bisphosphonate Sub-Study
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Nitrates (NABT Main trial)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Strengthening Care in Collaboration With People With Lived Experience of Psychosis in Uganda
Status: RECRUITING
Conditions: Psychosis
Interventions: OTHER: Primary care health worker training|OTHER: Community Health Workers Training|OTHER: Home visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk of Tuberculous and Other Infections in Patients of Spondyloarthritis Treated With Tofacitinib in Bangladesh
Status: UNKNOWN
Conditions: Spondyloarthritis
Interventions: DRUG: Tofacitinib 5 mg,|DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: NoL, HR and MABP Responses to Tracheal Intubation Performed With MAC Blade Versus Glidescope
Status: COMPLETED
Conditions: Intubation|Nociceptive Pain|Anesthesia|Laryngoscopy
Interventions: DEVICE: Laryngoscopy with GlideScope (GVL) Blade|DEVICE: Laryngoscopy with MacIntosh (MAC) Blade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Therapeutic Response of Sodium-glucose Co-transporter Type-2 Inhibitor in Non-diabetic MAFLD Patients: a Pilot Study
Status: RECRUITING
Conditions: Metabolic Associated Fatty Liver Disease
Interventions: DRUG: dapagliflozin (Forxiga)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: D-0316 Versus Icotinib in Patients With Locally Advanced or Metastatic EGFR Sensitising Mutation Positive NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer|EGFR Gene Mutation
Interventions: DRUG: D-0316 Capsule|DRUG: Icotinib Hydrochloride Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutrition Effects on Fatigue During Tennis Playing
Status: COMPLETED
Conditions: Fatigue
Interventions: DIETARY_SUPPLEMENT: Nutrattente / Nutraperf / Nutrarecup|DIETARY_SUPPLEMENT: Nutrattente placebo / Nutraperf placebo / Nutrarecup placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC)
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Livmoniplimab|DRUG: Budigalimab|DRUG: Durvalumab|DRUG: Atezolizumab|DRUG: Bevacizumab|DRUG: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Effects of the Environmental Change in Intestine by Antibiotics on the Pharmacokinetic Characteristics of Simvastatin in Healthy Male Volunteers
Status: COMPLETED
Conditions: Simvastatin Pharmacokinetics and Gut Microbiome
Interventions: DRUG: Vancomycin 250Mg Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: As an Early Indicator Biomarker of Prognosis and Mortality in Children With Sepsis and Septic Shock: suPAR
Status: COMPLETED
Conditions: Septic Shock|Sepsis, Severe
Interventions: DIAGNOSTIC_TEST: suPAR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ATS-1 Needle Free Injection Device Study-a Device for Administering r-hGH (Saizen) to Treat Growth Hormone Deficiency
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: ATS-1 needle free device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Vytorin Versus Placebo in Subjects With Primary Hypercholesterolemia (Study P04420)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: ezetimibe with simvastatin|DRUG: Ezetimibe with Simvastatin|DRUG: Ezetimibe with Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Economical Assessment of an Intervention to Reduce Potentially Inappropriate Medication in Polymedicated Elderly Patients
Status: COMPLETED
Conditions: Polypharmacy|Elderly
Interventions: PROCEDURE: Pharmacist Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Surface Texture and Clinical Performance of Milled BioHPP Polyetheretherketone (PEEK) Single Posterior Crowns Veneered With Two Different Techniques
Status: UNKNOWN
Conditions: Surface Roughness
Interventions: COMBINATION_PRODUCT: peek
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Energy Therapy in the Management of Chronic Pain Medical Condition in Children and Adolescents.
Status: RECRUITING
Conditions: Inflammatory Bowel Disease|Ulcerative Colitis|Crohn Disease|Chronic Pancreatitis
Interventions: OTHER: Energy Therapy - Pranic Healing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Adding Hyaluronidase to Bupivacaine in Transversus Abdominis Plane Block for Cesarean Section
Status: RECRUITING
Conditions: Pain, Postoperative
Interventions: DRUG: Hyaluronidase|DRUG: Bupivacaine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intervention Study Investigating the Effect of a Phospholipid Drink on Cognitive Performance in 6-8 Year Old School Children
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Lacprodan PL20|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase I Study of MLN 9708 in Addition to Chemotherapy for the Treatment of Acute Lymphoblastic Leukemia in Older Adults
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Lymphoblastic Lymphoma|B-cell Adult Acute Lymphoblastic Leukemia|T-cell Adult Acute Lymphoblastic Leukemia
Interventions: DRUG: MLN 9708|DRUG: Vincristine|DRUG: Cytarabine|DRUG: Doxorubicin|DRUG: Mercaptopurine|DRUG: Cyclophosphamide|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contrast-Enhanced Ultrasound vs Conventional US-guided Percutaneous Needle Biopsy for Pancreatic Diseases: Prospective Multicenter Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Disease
Interventions: DIAGNOSTIC_TEST: Contrast-enhanced ultrasound-guided core biopsy|DIAGNOSTIC_TEST: Conventional ultrasound-guided core biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of ITI-214 in Healthy Volunteers to Determine CNS Engagement
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: ITI-214|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficient Study of ACULAR in Inhibiting Proliferative Retinopathy in Prematurity
Status: TERMINATED
Conditions: Retinopathy of Prematurity|Retinal Detachment|Blindness
Interventions: DRUG: ACULAR|DRUG: REFRESH TEARS|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess PK, Safety and Tolerability Early in Healthy Subjects
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DRUG: QHRD106 Injection|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus
Status: COMPLETED
Conditions: Lichen Sclerosus of Vulva
Interventions: BIOLOGICAL: Platelet Rich Plasma|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Smoking Cessation Intervention for Head and Neck Cancer Patients
Status: UNKNOWN
Conditions: Smoking|Head and Neck Neoplasms
Interventions: BEHAVIORAL: Smoking cessation Intervention|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bone Marrow Derived Stem Cells Mobilization for Treatment of Abnormal Endometrium
Status: RECRUITING
Conditions: Asherman Syndrome|Atrophic Endometrium|Recurrent Implantation Failure
Interventions: DRUG: Plerixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BCD With or Without Doxycycline in Mayo Stage II-III Light Chain Amyloidosis Patients
Status: COMPLETED
Conditions: Amyloidosis; Systemic
Interventions: DRUG: Doxycycline|DRUG: Bortezomib|DRUG: Cyclophosphamide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Persistence of Immune Responses After Post-exposure Prophylaxis of Rabipur® (Purified Chicken-embryo Cell Rabies Vaccine) in Chinese Children
Status: COMPLETED
Conditions: Virus Diseases
Interventions: PROCEDURE: Blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Sperm Selection Technique Using Hyaluronic Acid Binding in Intra-cytoplasmic Sperm Injection (ICSI)
Status: COMPLETED
Conditions: Infertility, Male
Interventions: BIOLOGICAL: Hyaluronan binding system|OTHER: ICSI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EUS-Guided Cryothermal Ablation in Patients With Stage III Pancreatic Adenocarcinoma (HybridTherm Study)
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma Non-resectable
Interventions: DEVICE: Cryothermal ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Combination Chemotherapy Regimens in Treating Patients With Advanced Stomach Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: recombinant interferon alfa|DRUG: docetaxel|DRUG: doxorubicin hydrochloride|DRUG: fluorouracil|DRUG: hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (2)
Status: TERMINATED
Conditions: Generalized Anxiety Disorder
Interventions: DRUG: PD 0332334|DRUG: PD 0332334|DRUG: Paroxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of the BACE™ Device in the Treatment of Functional Mitral Valve Regurgitation [FMR
Status: UNKNOWN
Conditions: Functional Mitral Regurgitation
Interventions: DEVICE: BACE Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deprescribing in Patients Living With Dementia With Caregiver and Provider Nudges
Status: RECRUITING
Conditions: Alzheimer Disease|Mild Cognitive Impairment|Dementia
Interventions: BEHAVIORAL: Nudge Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Neoadjuvant PARP Inhibition Followed by Radical Prostatectomy in Patients With Unfavorable Intermediate-Risk or High-Risk Prostate Cancer With BRCA1/2 Gene Alterations
Status: RECRUITING
Conditions: Prostate Cancer|BRCA1 Mutation|BRCA2 Mutation|Prostatic Adenocarcinoma|High-Risk Cancer
Interventions: DRUG: Olaparib|DRUG: LHRH agonist
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Versus Patch Hormonal Contraceptive Effects on Metabolism, Clotting, Inflammatory Factors and Vascular Reactivity
Status: UNKNOWN
Conditions: Contraception
Interventions: DRUG: Ortho-Cyclen (R)|DRUG: Ortho Evra (R)|DRUG: extended use of Ortho Evra (R)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Forced Lefthandedness in Neonatal Brachial Plexus Palsy (NBPP) Children
Status: COMPLETED
Conditions: Neonatal Brachial Plexus Palsy
Interventions: DIAGNOSTIC_TEST: Functional testing, Magnetic resonance imaging, Electromyography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Dose Conversion From Vicodin® to Buprenorphine Transdermal System (Butrans™) in Subjects With OA Pain
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Buprenorphine transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Clinical Trial to Evaluate Paracetamol /Fexofenadine /Phenylephrine in Flu and Cold Treatment
Status: NOT_YET_RECRUITING
Conditions: Cold|Flu Symptom
Interventions: DRUG: Experimental drug (paracetamol 500mg / fexofenadine 60mg / phenylephrine 20mg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dexmedetomidine on the Emergence Agitation in Nasal Surgery
Status: COMPLETED
Conditions: Airway Extubation
Interventions: DRUG: Dexmedetomidine|DRUG: Normal saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Two Stepped Care Models for Posttraumatic Stress Disorder (PTSD) Among Cambodian Refugees With PTSD
Status: TERMINATED
Conditions: Posttraumatic Stress Disorder (PTSD)
Interventions: DRUG: Medication augmentation|BEHAVIORAL: CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of Morpheus8 Applicator for the Treatment of Focal Hyperhidrosis of the Axillae Using Radio Frequency
Status: RECRUITING
Conditions: Hyperhidrosis Primary Focal Axilla
Interventions: DEVICE: Morpheus8 Applicator (with the 24 pin tip) in the treatment of primary axillary hyperhidrosis.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: rTMS and Cognitive Training in Youth Depression
Status: COMPLETED
Conditions: Depression
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation|OTHER: Cognitive Training|OTHER: sham Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Treatment of Insomnia in Patients With HIV Disease
Status: COMPLETED
Conditions: HIV Infections|Insomnia
Interventions: DRUG: Doxepin|DRUG: Temazepam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Methods of Administration of the Epidural, by Programmed Intermittent Bolus or Continuous Perfusion, on the Incidence of Cesarean Sections and Instrumented Deliveries in Primiparous Women
Status: WITHDRAWN
Conditions: First Child Delivery With Epidural
Interventions: DRUG: Chirocaine 0.07% + Sufentanil 0.3 mcg/ml 10ml/h|DRUG: Chirocaine 0.07% + Sufentanil 0.3 mcg/ml 10ml each 60 minutes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Omnipod Horizon™ Automated Glucose Control System Preschool Cohort
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Omnipod Horizon™ Automated Glucose Control System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of BCX4430
Status: COMPLETED
Conditions: Filovirus Infections|Ebola Virus Infection
Interventions: DRUG: BCX4430|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Roles of Vitamin D and Microbiome in Children With Post-acute COVID-19 Syndromes (PACS) and Long COVID
Status: RECRUITING
Conditions: Post-acute COVID-19 Syndromes
Interventions: OTHER: Vitamin D|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effects of RoActemra/Actemra (Tocilizumab) on Neutrophils in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Biologic and/or Non-biologic DMARDs.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tocilizumab [RoActemra/Actemra]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Memory Enhancement Using Transcranial Alternating Current Stimulation
Status: NOT_YET_RECRUITING
Conditions: Alzheimer Disease|Mild Cognitive Impairment
Interventions: DEVICE: Gamma (40 Hz) tACS at the precuneus region|DEVICE: Sham tACS at the precuneus region
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improved Diagnostics in Food Allergy Study
Status: ENROLLING_BY_INVITATION
Conditions: Food Allergy
Interventions: DIAGNOSTIC_TEST: Intranasal food challenge|DIAGNOSTIC_TEST: Mast cell activation test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: INTREPId (INTermediate Risk Erection PreservatIon Trial)
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Bicalutamide|DRUG: GnRH Agonist|RADIATION: Radiation Therapy|DRUG: Darolutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reach and Palmar Grasp in Tetraplegics With Neuromuscular Electrical Stimulation: Assessment and Training.
Status: COMPLETED
Conditions: Tetraplegia|Tetraparesis
Interventions: OTHER: Assessment of upper limb variables|OTHER: Training protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Low-Dose Conditioning Followed by Donor Stem Cell Transplant in Treating Patients With Severe Systemic Sclerosis
Status: WITHDRAWN
Conditions: Systemic Scleroderma
Interventions: DRUG: fludarabine phosphate|RADIATION: total-body irradiation|DRUG: tacrolimus|DRUG: mycophenolate mofetil|BIOLOGICAL: rituximab|DRUG: cyclophosphamide|PROCEDURE: nonmyeloablative allogeneic hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Intervene With Nutrition for Gastroparesis
Status: TERMINATED
Conditions: Gastroparesis
Interventions: DIETARY_SUPPLEMENT: Assess the nutritional effects of the Kate Farm Peptide 1.5 nutritional Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Feeding Infant Formula With Bimuno Galactooligosaccharide (GOS)
Status: COMPLETED
Conditions: Dietary Modification
Interventions: DIETARY_SUPPLEMENT: GOS|DIETARY_SUPPLEMENT: B-GOS 3%|DIETARY_SUPPLEMENT: B-GOS 2%|DIETARY_SUPPLEMENT: Mother's breast milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: MAD Study of IA-14069
Status: RECRUITING
Conditions: Healthy|Rheumatoid Arthritis
Interventions: DRUG: IA-14069|DRUG: Placebo|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of L. Reuteri in Urinary Tract Infections in Non Pregnant Women
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: COMBINATION_PRODUCT: Lactobacillus reuteri|DIETARY_SUPPLEMENT: Sachet with cranberry + placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Probiotics and Electrophysiologic Therapy on Endometrium Repair
Status: UNKNOWN
Conditions: Uterine Endometrial Repair
Interventions: DRUG: probiotics|DEVICE: Electrophysiologic Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of New Generation Hormono-therapy on Cognitive Functions in Elderly Patients Treated for a Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Metastatic Castration-resistant Prostate Cancer (CRPCa)
Interventions: OTHER: neuropsychologic evaluation|OTHER: oncogeriatric evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Tolerability and PK/PD of RB006 in a Healthy Volunteer SAD
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Subcutaneous RB006 0.5 mg/kg|DRUG: Subcutaneous RB006 1.0 mg/kg|DRUG: Subcutaneous RB006 3.0 mg/kg|DRUG: Subcutaneous RB006 2.0 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Neuromuscular Ultrasonography Utility for Detection of Peripheral Neuropathy in Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Peripheral Neuropathy|System; Lupus Erythematosus
Interventions: DIAGNOSTIC_TEST: neuromuscular ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Performance and Patient Satisfaction of Cerasmart Versus Lithium Disilicate (E-max) Endocrowns
Status: UNKNOWN
Conditions: Endodontically Treated Teeth
Interventions: OTHER: E-max Endocrown|OTHER: Cerasmart Endocrown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Examining the Effect of Ondansetron on Bowel Prep Success
Status: COMPLETED
Conditions: Abdominal Pain|Inflammatory Bowel Diseases|Eosinophilic Gastroenteritis|Diarrhea|Hematochezia|Weight Loss
Interventions: DRUG: Ondansetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Treatment of Alveolar Osteitis: Traditional or Regenerative?
Status: RECRUITING
Conditions: Alveolar Osteitis|Dry Socket|Pain|Healing|Tooth Extraction
Interventions: BIOLOGICAL: Bio-PRF|DRUG: Alveogyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 90 mg Fluoxetine Hydrochloride Capsules Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Fluoxetine Hydrochloride|DRUG: PROZAC WEEKLY®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Study to Assess Relative Bioavailability and Food Effect of New Formulations of GSK2248761
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus|HIV Infections
Interventions: DRUG: GSK2248761 formulation 1|DRUG: GSK2248761 reference formulation|DRUG: GSK2248761 formulation 3|DRUG: GSK2248761 formulation 2 or 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Pulsed Dye Laser and Topical Ranibizumab for Treatment of Port Wine Stain Birthmarks
Status: WITHDRAWN
Conditions: Port-Wine Stain
Interventions: DRUG: Ranibizumab|DEVICE: Pulsed Dye Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effectiveness of Paclitaxel-eluting Balloons for Below-the-knee Angioplasty in Patients With Critical Limb Ischemia
Status: UNKNOWN
Conditions: Critical Limb Ischemia
Interventions: PROCEDURE: paclitaxel eluting balloon angioplasty in below-the-knee lesions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Disrupted Sleep, Neuroendocrine Status and the Behavioral Symptoms of AD
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: BEHAVIORAL: Timed Planned Activity|BEHAVIORAL: Home Safety and Education Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of rTMS Plus Rehabilitation for the Improvement of the Upper Extremity in Stroke (ERES)
Status: UNKNOWN
Conditions: Stroke|Arm Paralysis
Interventions: DEVICE: Real rTMS (Magstim)|DEVICE: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Different Concentrations of Potassium Nitrate in In-office Tooth Bleaching Sensitivity
Status: COMPLETED
Conditions: Tooth Sensitivity
Interventions: DRUG: 3% potassium nitrate and 0.25% sodium fluoride|DRUG: 5% potassium nitrate and 2% sodium fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: HGS-ETR2 to Treat Children With Solid Tumors
Status: TERMINATED
Conditions: Ewing's Sarcoma|Osteosarcoma|Neuroblastoma|Rhabdomyosarcoma
Interventions: DRUG: Lexatumumab alone|DRUG: Lexatumumab in combination|DRUG: Interferon gamma 1b in combination|DRUG: Gamma 1b potential expansion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neutrophil Elastase Inhibitor in Treatment of ARDS Patients With Mechanical Ventilation Caused by Sepsis
Status: NOT_YET_RECRUITING
Conditions: Acute Respiratory Distress Syndrome
Interventions: DRUG: Sivelestat sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy in Unresectable Gall Bladder Cancer
Status: RECRUITING
Conditions: Gall Bladder Cancer
Interventions: DRUG: Systemic therapy (Gemcitabine plus Cisplatin)|RADIATION: RT|DRUG: Systemic therapy (Gemcitabine plus oxaliplatin)|DRUG: Systemic therapy (Gemcitabine plus Cisplatin plus Durvalumab)|DRUG: Systemic therapy (Gemcitabine plus cisplatin plus nab-paclitaxel)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AZD2171 in Treating Patients With Neurofibromatosis Type 1 and Plexiform Neurofibroma and/or Neurofibroma Near the Spine
Status: TERMINATED
Conditions: Neurofibromatosis Type 1|Plexiform Neurofibroma|Spinal Cord Neurofibroma
Interventions: DRUG: Cediranib Maleate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Suprachoroidal Triamcinolone Acetonide to Treat Macular Edema in Retinal Vein Occlusion
Status: COMPLETED
Conditions: Macular Edema|Retinal Vein Occlusion
Interventions: DRUG: suprachoroidal injection of Triamcinolone Acetonide.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Oncoxin-Viusid® in Head and Neck Cancer
Status: COMPLETED
Conditions: Head Cancer Neck
Interventions: DIETARY_SUPPLEMENT: Oncoxin-Viusid®|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Safety/Tolerability and Pharmacokinetics (PKs) of Naftopidil in Korean Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Naftopidil
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: JAB-2485 Activity in Adult Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Solid Tumors|ER+ Breast Cancer|Triple Negative Breast Cancer, TNBC|ARID1A Gene Mutation|Small Cell Lung Cancer, SCLC
Interventions: DRUG: JAB-2485 (Aurora A inhibitor)|DRUG: JAB-2485 (Aurora A inhibitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PegIFN Alfa-2a and RBV for 16 or 24 Weeks in Patients With Chronic Hepatitis C(CHC) 2 With Rapid Virologic Response(RVR)
Status: UNKNOWN
Conditions: Chronic Hepatitis C
Interventions: DRUG: Peginterferon alfa-2a and Ribavirin|DRUG: Peginterferon alfa-2a and Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Investigating the Ability of Plant Exosomes to Deliver Curcumin to Normal and Colon Cancer Tissue
Status: RECRUITING
Conditions: Colon Cancer
Interventions: DIETARY_SUPPLEMENT: curcumin|DIETARY_SUPPLEMENT: Curcumin conjugated with plant exosomes|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Inspiratory Muscle Training in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: COPD|Inspiratory Muscle Weakness
Interventions: OTHER: Inspiratory Muscle Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT