pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study for Subjects With Chronic Kidney Disease(CKD) Not Receiving Dialysis
Status: COMPLETED
Conditions: Chronic Kidney Disease|Kidney Disease
Interventions: DRUG: De Novo Administration of Darbepoetin Alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nonpharmacologic Reduction of Periprocedural Distress and Drug Use
Status: COMPLETED
Conditions: Dental Anxiety|Dental Pain|Drug Use|Opioid Use
Interventions: OTHER: Comfort Talk® app|OTHER: White Noise app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Value of Traction in the Treatment of Cervical Radiculopathy
Status: COMPLETED
Conditions: Radiculopathy|Neck Pain|Spinal Diseases|Musculoskeletal Diseases|Neuromuscular Diseases|Intervertebral Disk Displacement
Interventions: OTHER: Physical therapy rehabilitation|OTHER: Physical therapy rehabilitation|OTHER: Physical therapy rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of the Combination of Olmesartan and Hydrochlorothiazide in Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: olmesartan medoxomil (OM)/hydrochlorothiazide (HCTZ) tablets and placebo|DRUG: olmesartan medoxomil (OM)/hydrochlorothiazide (HCTZ) tablets|DRUG: olmesartan medoxomil/hydrochlorothiazide tablets|DRUG: olmesartan medoxomil/hydrochlorothiazide tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of Cabozantinib for Advanced HCC Patients With Preserved Liver Function
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma (HCC)|Second Line Treatment
Interventions: DRUG: Cabozantinib Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Changes in the Use of Care and Reorganization of the Healthcare System Linked to the Covid-19 Outbreak on the Quality of Care Pathways of Patients Suffering From Acute Myocardial Infarction and Stroke in Aquitaine (AVICOVID)
Status: COMPLETED
Conditions: Coronavirus Disease 2019|Stroke|Acute Myocardial Infarction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Iontophoresis With Potassium Iodide and Thyroid Function
Status: COMPLETED
Conditions: Thyroid Dysfunction
Interventions: PROCEDURE: Iontophoresis with 2% potassium iodide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Erwinaze Administered Intravenously in Patients Who Had an Allergy to Frontline Asparaginase Therapy
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Lymphoblastic Lymphoma
Interventions: DRUG: asparaginase Erwinia chrysanthemi
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-confirmation Study of ASLAN001 Combined With Weekly Paclitaxel and Carboplatin in Advanced Solid Tumours, Followed by a Study in Patients With Stage I-III HER2 Positive Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Paclitaxel + Carboplatin + ASLAN001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visualization of the Effect of Acupuncture on Brain Serotonin in Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: Single Photon Emission Computed Tomography|PROCEDURE: Acupuncture Therapy|OTHER: Questionnaire Administration|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Adding Motion to Contact: A New Model for Low-cost Family Centered Very-early Onset Intervention in Very Preterm-born Infants
Status: UNKNOWN
Conditions: Premature Birth|Brain Injuries
Interventions: BEHAVIORAL: Multisensory Stimulation and Family Education Group|BEHAVIORAL: Family Education Only Group (FEG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Collection of PillCam SB3 Videos and Raw Data Files for Future Developments (SODA)
Status: RECRUITING
Conditions: Small Intestine Disease|Small Intestine Cancer|Small Intestinal Ulcer Bleeding|Small Intestine Obstruction|Small Intestine Adenocarcinoma|Small Intestine Polyp
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: RFN for SIJ Disease Study
Status: UNKNOWN
Conditions: Sacro Iliac Joint Pain
Interventions: PROCEDURE: Comparison of active versus sham radiofrequency neurotomy with Simplicity III
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of LycoComfort™ Supplementation on Symptoms Associated With Lower Urinary Tract Symptoms (LUTS)
Status: COMPLETED
Conditions: BPH|Lower Urinary Tract Symptoms
Interventions: DIETARY_SUPPLEMENT: Lycocomfort
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neoadjuvant Doxorubicin, Polyglutamate Paclitaxel, Capecitabine and Metronomic Chemotherapy in Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: doxorubicin, paclitaxel poliglumex, capecitabine, cyclophosphamide, methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cidofovir in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer Who Are Receiving Chemotherapy and Radiation Therapy
Status: UNKNOWN
Conditions: Cervical Cancer|Precancerous Condition
Interventions: DRUG: carboplatin|DRUG: cidofovir|GENETIC: protein expression analysis|OTHER: laboratory biomarker analysis|RADIATION: brachytherapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Inhaled AmBisome for Prevention of Aspergillus Colonization in Lung Transplant Recipients
Status: SUSPENDED
Conditions: Lung Transplant Recipient
Interventions: DRUG: Ambisome ®|DRUG: Regular standard of care medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: MINS, AKI and Pulmonary Pathology in Patients Undergoing Acute Abdominal Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Abdomen, Acute|Myocardial Injury|Acute Kidney Injury|Pulmonary Disease
Interventions: DIAGNOSTIC_TEST: Chest CT without contrast enhancement and chest X-ray
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: DANHEART (H-HeFT and Met-HeFT)
Status: RECRUITING
Conditions: Heart Failure|Diabetes
Interventions: DRUG: Hydralazine Isosorbide Dinitrate|DRUG: Placebo Oral Tablet|DRUG: Metformin Hydrochloride|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Geldanamycin Analogue in Treating Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Non-Hodgkin Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Splenic Marginal Zone Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: tanespimycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Bronchodilator Response From Three Different Aerosol Delivery Methods in Patients With COPD Using Hyperpolarized Xe 129 MRI Ventilation Imaging
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Albuterol Sulfate, 2.5 Mg/3 mL (0.083%) Inhalation Solution|DEVICE: Vibrating Mesh Nebulizer|DEVICE: Metered Dose Inhaler|DEVICE: Jet Nebulizer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Investigate the Multiple Dose Safety, Tolerability and Pharmacokinetics of WCK 4282 (FEP-TAZ)
Status: COMPLETED
Conditions: Antibiotics Causing Adverse Effects in Therapeutic Use
Interventions: DRUG: FEP-TAZ 4 g|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Safety and Pharmacokinetics Trial of VO659 in SCA1, SCA3 and HD
Status: RECRUITING
Conditions: Spinocerebellar Ataxia Type 1|Spinocerebellar Ataxia Type 3|Huntington Disease
Interventions: DRUG: VO659
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-Blind, Double Dummy, Randomized Comparison Study to Evaluate the Efficacy and Safety of Valdecoxib 10 mg Once Daily and Naproxen 500 mg Twice Daily in Treating the Signs and Symptoms of Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis|Knee
Interventions: DRUG: valdecoxib|DRUG: naproxen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Pembrolizumab and Metformin Versus Pembrolizumab Alone in Advanced Melanoma
Status: RECRUITING
Conditions: Advanced Melanoma
Interventions: DRUG: Pembrolizumab Injection [Keytruda]|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of GP681 Tablets Compared With Placebo in Patients With Influenza at High Risk of Influenza Complications
Status: NOT_YET_RECRUITING
Conditions: Influenza, Human
Interventions: DRUG: GP681 40mg|DRUG: GP681 Simulant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Letrozole Combined With Gonadotropins (Gn) for Ovarian Stimulation Undergoing in Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) in Patients With Polycystic Ovary Syndrome (PCOS)
Status: UNKNOWN
Conditions: Polycystic Ovarian Syndrome
Interventions: DRUG: letrozole + gonadotropins|DRUG: GnRHa + gonadotropins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenomic Study of Docetaxel and Cisplatin, Followed by Docetaxel, Cisplatin and Irradiation.
Status: TERMINATED
Conditions: Esophageal Adenocarcinomas|Adenocarcinomas of the Gastroesophageal Junction
Interventions: DRUG: docetaxel|DRUG: cisplatin|PROCEDURE: radiation|PROCEDURE: surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interactive Telehealth Intervention to Increase Longitudinal Adherence to Repeat Faecal Immunochemical Test Screening
Status: NOT_YET_RECRUITING
Conditions: CRC, Colorectal Cancer
Interventions: BEHAVIORAL: TI group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Efficacy and Safety of Adding Methotrexate to Etanercept in Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Methotrexate|DRUG: Etanercept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Therapy of Abiraterone Plus ADT for Intraductal Carcinoma of the Prostate
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Abiraterone acetate|DRUG: Prednisolone|DRUG: Goserelin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Cross-over Bioequivalence Study of E3810 for Healthy Japanese Male (Under Postprandial Condition)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: rabeprazole|DRUG: rabeprazole|DRUG: rabeprazole|DRUG: rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spinal Cord Innovation in Pediatrics (SCiP) to Treat SensoriMotor Function in Children Cerebral Palsy: Protocol for a Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Cerebral Palsy
Interventions: DEVICE: SCiP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety of Anrotinib Hydrochloride Capsule in Postoperative Non-pCR Patients With Non-small Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Event-free Lifetime
Interventions: DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [COVID-19] Reduction of Sars-CoV-2 Oral Viral Load With Prophylactic Mouth Rinse
Status: UNKNOWN
Conditions: Covid19
Interventions: OTHER: Water (E) Mouth rinse with the solution provided|OTHER: Chlorhexidine gluconate (A) Mouth rinse with the solution provided|OTHER: Hydrogen peroxide (B) Mouth rinse with the solution provided|OTHER: Betadine (C) Mouth rinse with the solution provided|OTHER: Alcohol mouthwash (Listerine) (D) Mouth rinse with the solution provided
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Open Label Phase I Study of Subcutaneously Administered Recombinant Human GM-CSF in Patients With AIDS Virus Infection and Leukopenia
Status: COMPLETED
Conditions: HIV Infections|Cytopenias
Interventions: DRUG: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Carotuximab (TRC105) Plus Nivolumab in Patients With Metastatic NSCLC
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Carotuximab (TRC105)|DRUG: OPDIVO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Savolitinib Combined With Osimertinib in Treatment of Advanced NSCLC With MET Amplification
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Savolitinib + Osimertinib|DRUG: Pemetrexed + Cisplatin /Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety Study of the GORE® HELEX® Septal Occluder
Status: COMPLETED
Conditions: Septal Defect, Atrial
Interventions: DEVICE: GORE® HELEX® Septal Occluder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Non-Inferiority of Pancreatic Enzymes (Norzyme ® - Bergamo) Compared To Creon ® (Solvay Pharmaceutical) in Patients With Exocrine Pancreatic Insufficiency
Status: UNKNOWN
Conditions: Pancreatic Insufficiency
Interventions: DIETARY_SUPPLEMENT: Norzyme - Bergamo|DIETARY_SUPPLEMENT: Creon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Immunogenicity of the Recombinant ZR202-CoV and ZR202a-CoV Vaccines in Adults.
Status: ACTIVE_NOT_RECRUITING
Conditions: SARS-CoV-2 Infection|COVID-19
Interventions: BIOLOGICAL: ZR202-CoV|BIOLOGICAL: ZR202a-CoV|BIOLOGICAL: Comirnaty®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Long-term Remote Ischemic Preconditioning Improves Myocardial Perfusion and Prognosis of Patients After CABG
Status: RECRUITING
Conditions: Coronary Disease
Interventions: OTHER: remote ischemic preconditioning （RIPC）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Peri-neural Platelet Rich Plasma Injection in Treatment of Chemotherapy Induced Peripheral Neuropathy.
Status: UNKNOWN
Conditions: Chemotherapy-induced Peripheral Neuropathy
Interventions: DRUG: platelet rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AMBU Bag Manual Ventilation vs. Transport Ventilator Mechanical Ventilation for Transport
Status: RECRUITING
Conditions: Oxygenation|Manual Ventilation|Mechanical Ventilation|Point of Care Ultrasound|Cardiac Function Disturbance Postoperative
Interventions: DEVICE: Hamilton C1 ventilator during transport to the ICU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Geodon (Ziprasidone) for Posttraumatic Stress Disorder
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder|Post-Traumatic Stress Disorder|PTSD
Interventions: DRUG: Ziprasidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Scintigraphic Evaluation of Contractile and Coronary Reserve in Patients With Ischemic Cardiomyopathy
Status: COMPLETED
Conditions: Ischemic Cardiomyopathy
Interventions: DIAGNOSTIC_TEST: Stress Gated blood pool SPECT|DIAGNOSTIC_TEST: Dynamic SPECT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: [18F] PSMA-1007 PET/CT in Metastatic Clear Cell Renal Cell Carcinoma
Status: RECRUITING
Conditions: Metastatic Clear Cell Renal Cell Carcinoma
Interventions: DIAGNOSTIC_TEST: [18F] PSMA-1007 PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: taVNS Paired With Bottle Feeding in Infants Failing Oral Feeds
Status: COMPLETED
Conditions: Poor Feeding|Infant Development|Vagus Nerve Stimulation
Interventions: DEVICE: transcutaneous auricular vagus nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bisphosphonate Therapy for HIV-Infected Adults With Decreased Bone Mineral Density
Status: UNKNOWN
Conditions: HIV Infections|Osteopenia|Osteoporosis
Interventions: DRUG: Zoledronate|DRUG: Zoledronate placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Dexmedetomidine vs Epinephrine
Status: NOT_YET_RECRUITING
Conditions: Cesarean Section|Anesthesia, Spinal
Interventions: DRUG: Dexmedetomidine|DRUG: Epinephrine|DRUG: Standardized Spinal Mixture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Subcutaneous Sarilumab in Hospitalised Patients With Moderate-severe COVID-19 Infection (SARCOVID)
Status: COMPLETED
Conditions: Covid-19
Interventions: DRUG: Sarilumab|OTHER: Standar of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Encorafenib and Binimetinib Before Local Treatment in Patients With BRAF Mutant Melanoma Metastatic to the Brain
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Melanoma|Brain Metastases
Interventions: DRUG: encorafenib|DRUG: binimetinib|RADIATION: Whole brain radiation therapy|RADIATION: Radiosurgery/stereotactic radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Famvir for Treatment of Hearing in Unilateral Meniere's Disease
Status: TERMINATED
Conditions: Meniere's Disease
Interventions: DRUG: Famciclovir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Respiratory Effects of Dopamine in the Perioperative Care
Status: UNKNOWN
Conditions: Dopamine|Bronchodilation|Heart|Surgery|Functional Disturbance
Interventions: DRUG: Dopamine administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Low-Dose Cytarabine and Etoposide With or Without All-Trans Retinoic Acid in Older Patients Not Eligible for Intensive Chemotherapy With Acute Myeloid Leukemia and NPM1 Mutation
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: Cytarabine|DRUG: Etoposide|DRUG: All-trans retinoic acid (ATRA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3 Years of Anastrozole vs. no Treatment as Extended Adjuvant Therapy for Postmenopausal Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Anastrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementing a Digitally-enabled Community Health Worker Intervention for Patients With Heart Failure
Status: RECRUITING
Conditions: Heart Failure，Congestive
Interventions: OTHER: Digitally-enabled CHW Care|BEHAVIORAL: Usual CHW Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Adaptive Interventions for Problem Drinkers
Status: COMPLETED
Conditions: Alcohol-Related Disorders|Alcohol Use Disorders|Alcohol Drinking|Alcoholism|Alcohol Abuse
Interventions: BEHAVIORAL: Brief Advice|BEHAVIORAL: Motivational Interviewing|BEHAVIORAL: Behavioral Self-Control Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of PC Sequential Pemetrexed Single Drug Maintenance Treatment for NSCLC and Related Predictive Biomarkers
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: pemetrexed /carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increased Home-based Physical Therapy Adherence Using BAND Connect's VirtuaCare™ Platform
Status: RECRUITING
Conditions: Shoulder Injuries
Interventions: OTHER: BAND Connect's VirtuaCare™ platform|OTHER: Standard of Care Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bulk-fill With Different Technique Three-year Clinical Performance
Status: ACTIVE_NOT_RECRUITING
Conditions: Bulk-fill Which is Special Type of Resin Composite|Bisphenol A-Glycidyl Methacrylate
Interventions: OTHER: Filtek™ Bulk Fill restoration|OTHER: Heated Filtek™ Bulk Fill restoration|OTHER: G-aenial™ BULK Injectable restoration|OTHER: Sonicfill3 restoration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nudging Nutrition With Monetary Incentives Environmental Cues
Status: COMPLETED
Conditions: Obesity|Food Labeling|Health Behavior|Diet
Interventions: BEHAVIORAL: Subsidy|BEHAVIORAL: Tax|BEHAVIORAL: Tax and subsidy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: Psilocybin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Detection and Characterisation of Varicella Zoster Virus From Dermal Lesions of Chickenpox-infected Patients
Status: COMPLETED
Conditions: Varicella
Interventions: PROCEDURE: Collection of clinical samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: EUROpean Coronary microCirculatory Resistance and Absolute Flow Trial
Status: UNKNOWN
Conditions: Microvascular Angina|Microvascular Coronary Artery Disease|Coronary Vasospasm|Microvascular Resistance
Interventions: DIAGNOSTIC_TEST: absolute flow and resistance measurements
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Yogurt Probiotic Bacteria on Relieving Young Children Acute Gastroenteritis
Status: COMPLETED
Conditions: Acute Gastroenteritis
Interventions: DIETARY_SUPPLEMENT: yogurt with probiotic bacteria
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lanreotide Autogel and Pegvisomant Combination Therapy in Acromegalic Patients
Status: COMPLETED
Conditions: Acromegaly
Interventions: DRUG: lanreotide (Autogel formulation)|DRUG: Pegvisomant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Injectable Collagen Scaffold™ Combined With HUC-MSCs for the Improvement of Erectile Function in Men With Diabetes
Status: UNKNOWN
Conditions: Erectile Dysfunction|Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus
Interventions: BIOLOGICAL: HUC-MSCs|BIOLOGICAL: Injectable Collagen Scaffold + HUC-MSCs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of Umbilical Cord Cleansing With 4.0% Chlorhexidine on Neonatal Mortality
Status: COMPLETED
Conditions: Omphalitis|Infection
Interventions: BEHAVIORAL: chx once|BEHAVIORAL: CHX x 7 days|BEHAVIORAL: dry cord care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Open-label, Single-arm Longitudinal Study With Dupilumab for Patients With Atopic Dermatitis
Status: UNKNOWN
Conditions: Atopic Dermatitis|AD|Eczema
Interventions: DRUG: Dupilumab Only Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Development of Liquid Biopsy Technologies for Noninvasive Cancer Diagnostics in Patients With Suspicious Thyroid Nodules or Thyroid Cancer
Status: SUSPENDED
Conditions: Thyroid Gland Carcinoma|Thyroid Gland Nodule
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Electronic Health Record Review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ischaemic Pre-Conditioning in Elective Percutaneous Coronary Intervention (PCI) Patients
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: Angioplasty balloon|DEVICE: Angioplasty balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Talquetamab in Combination With Iberdomide and Dexamethasone for Relapsed or Refractory Multiple Myeloma
Status: NOT_YET_RECRUITING
Conditions: Multiple Myeloma|Refractory Multiple Myeloma|Relapsed Multiple Myeloma
Interventions: BIOLOGICAL: Talquetamab|DRUG: Iberdomide|DRUG: Dexamethasone|PROCEDURE: Bone Marrow Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychological Management by Meditation of Full COnscience in Virtual REality of People With Amyotrophic Lateral Sclerosis: Effects on Cognition, Behavior, Quality of Life and Psychological Well-being
Status: UNKNOWN
Conditions: Lateral Sclerosis Amyotrophy|Mindfulness Meditation
Interventions: OTHER: mindfulness meditation care|OTHER: no mindfulness meditation care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: An Expanded Access Study to Provide at Home Subcutaneous Administration of Pertuzumab and Trastuzumab Fixed-Dose Combination (PH FDC SC) for Patients With HER2-Positive Breast Cancer During the COVID-19 Pandemic
Status: APPROVED_FOR_MARKETING
Conditions: HER2-positive Breast Cancer
Interventions: DRUG: Pertuzumab and Trastuzumab Fixed-Dose Combination for Subcutaneous Administration (PH FDC SC)
Study Type: EXPANDED_ACCESS
Clinical trial: Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up Study
Status: WITHDRAWN
Conditions: Renal Insufficiency, Chronic
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Kidney Injury Among Pediatric Cancer Patients At South Egypt Cancer Institute
Status: NOT_YET_RECRUITING
Conditions: To Determine the Cumulative Incidence of AKI Using KDIGO Criteria in Pediatric Patients With Malignancy in South Egypt Cancer Institute (SECI)
Interventions: DIAGNOSTIC_TEST: kidney function test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Rollover Study of Ixabepilone (BMS-247550) In Patients With Metastatic Breast Cancer Previously Treated With An Anthracycline
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Ixabepilone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of HS-10374 Compared to Placebo in Adults With Active Psoriatic Arthritis
Status: RECRUITING
Conditions: Psoriatic Arthritis
Interventions: DRUG: HS-10374|DRUG: HS-10374-matched placebo tablets|DRUG: Tofacitinib 5Mg Tab,Oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Amifostine and IMRT for Protecting Salivary Glands in Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: Ethyol (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liraglutide as Additional Treatment to Insulin in Patients With Autoimmune Diabetes Mellitus
Status: UNKNOWN
Conditions: Type 1 Diabetes Mellitus|Autoimmune Diabetes
Interventions: DRUG: Liraglutide|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Sleeve Gastrectomy: a Cohort Study
Status: COMPLETED
Conditions: Laparoscopic Sleeve Gastrectomy
Interventions: PROCEDURE: 4-6cm from starting point of gastrectomy to pylorus|PROCEDURE: 2-4cm from starting point of gastrectomy to pylorus
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prophylactic Effect of Ketorolac Tromethamine on the Cystoid Macular Edema After Phacoemulsification in Diabetic Patients
Status: UNKNOWN
Conditions: Cystoid Macular Edema After Phacoemulsification
Interventions: DRUG: using of Ketorolac Tromethamine Eye Drop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Medications for Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia
Status: RECRUITING
Conditions: Enlarged Prostate With Lower Urinary Tract Symptoms
Interventions: DRUG: Vardenafil 5 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Use of the Tx360 Nasal Applicator in the Treatment of Chronic Migraine
Status: COMPLETED
Conditions: Chronic Migraine
Interventions: DRUG: Marcaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Disitamab Vedotin With Toripalimab Verus Disitamab Vedotin in Hormone Receptor Positive, HER2-low Locally Advanced or Metastatic Breast Cancer
Status: WITHDRAWN
Conditions: Breast Neoplasms
Interventions: DRUG: Disitamab Vedotin|DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Artificial Intelligence in Diagnosing Dysphagia Patients
Status: COMPLETED
Conditions: Respiration Disorders|Swallowing Disorder|Phonation Disorder|Stroke|Aspiration Pneumonia|Aspiration; Liquids
Interventions: OTHER: Acoustic features (from signals obtained during phonation)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of IV Infusion of Investigational Agent (TZP-101) in Patients With Diabetic Gastroparesis
Status: COMPLETED
Conditions: Gastroparesis|Diabetes Mellitus
Interventions: DRUG: 5% dextrose in water|DRUG: TZP-101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Arachidonate 5-Lipoxygenase Enzyme in Affecting the Risk for Coronary Heart Disease
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DRUG: montelukast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intradermal Tozinameran for Patients With Immune-mediated Dermatologic Diseases
Status: COMPLETED
Conditions: Bullous Dermatoses|Psoriasis|COVID-19 Vaccines
Interventions: BIOLOGICAL: tozinameran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sitagliptin and Pioglitazone Mechanism of Action Study in Type 2 Diabetes Mellitus (0431-061)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus (T2DM)
Interventions: DRUG: Comparator: sitagliptin phosphate|DRUG: Comparator: pioglitazone|DRUG: Comparator: placebo to pioglitazone|DRUG: Comparator: placebo to sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Optimization Through Pleth Variability Index for OHCA
Status: UNKNOWN
Conditions: Cardiac Arrest With Successful Resuscitation
Interventions: DEVICE: Pleth variability index|DEVICE: Standard non invasive monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Residual Gastric Volume in Morbidly Obesa Diabetics. A Comparison of 3 Hour Versus Hour Fasting.
Status: COMPLETED
Conditions: Obesity|Diabetes|Fasting
Interventions: OTHER: Endoscopic examinations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Emboshield® and Xact® Post Approval Carotid Stent Trial (The EXACT Study)
Status: COMPLETED
Conditions: Carotid Artery Disease|Carotid Stenosis|Stroke|Atherosclerosis
Interventions: DEVICE: Carotid artery stenting with filter (interventional)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Hyperuricaemia on Chronic Renal Disease
Status: UNKNOWN
Conditions: Hyperuricemia|Chronic Renal Disease
Interventions: DRUG: 20mg Febuxostat|DRUG: 40mg Febuxostat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcome After Close Rectal Ileo Pouch Anal Anastomosis for Colitis Ulcerosa(CU)
Status: UNKNOWN
Conditions: Ulcerative Colitis
Interventions: PROCEDURE: Close Rectal Dissection - IPAA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effectiveness and Safety of Topiramate in the Treatment of Moderate to Severe Binge-eating Disorder Associated With Obesity
Status: COMPLETED
Conditions: Obesity|Binge-Eating Disorder
Interventions: DRUG: topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Akt Inhibitor MK-2206 and Anastrozole With or Without Goserelin Acetate in Treating Patients With Stage II-III Breast Cancer
Status: TERMINATED
Conditions: Estrogen Receptor Positive|HER2/Neu Negative|Recurrent Breast Carcinoma|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: DRUG: Akt Inhibitor MK2206|DRUG: Anastrozole|DRUG: Goserelin Acetate|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Neoadjuvant Therapy|OTHER: Pharmacological Study|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Axitinib and Oral Metronomic Etoposide for Pediatric Children and AYA Refractory/Relapsing Medulloblastoma and Ependymoma
Status: NOT_YET_RECRUITING
Conditions: Medulloblastoma|Ependymoma
Interventions: DRUG: administration of axitinib in combination with etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Berlim 25/10 Association in the Treatment of Type II Diabetes Mellitus and Dyslipidemia
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes Mellitus|Dyslipidemia
Interventions: DRUG: BERLIM 25/10 association|DRUG: EMPAGLIFLOZIN|DRUG: ROSUVASTATIN CALCIUM|OTHER: BERLIM 25/10 ASSOCIATION PLACEBO|OTHER: EMPAGLIFLOZIN PLACEBO|OTHER: ROSUVASTATIN CALCIUM PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Compare the Agility Exercise and Resistance Exercise on Physical Function and Stability in Osteoporotic Women
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis|Agility Exercise|Physical Function|Balance Stability|Fall Prevention
Interventions: BIOLOGICAL: Physical training of agility|BIOLOGICAL: Physical training of resistance
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: STI Combined to Valsalva Maneuver for the Diagnosis of Left Ventricular Dysfunction in COPD Exacerbations
Status: COMPLETED
Conditions: Obstructive Chronic Bronchitis With Acute Exacerbation
Interventions: DEVICE: STI measurements at baseline and under Valsalva maneuver
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Melatonin Supplements for Improving Sleep in Individuals With Hypertension
Status: COMPLETED
Conditions: Sleep Disorders|Hypertension
Interventions: DRUG: Melatonin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Atorvastatin to Treat Pulmonary Sarcoidosis
Status: COMPLETED
Conditions: Sarcoidosis, Pulmonary
Interventions: DRUG: Atorvastatin|OTHER: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Front of Pack Nutritional Labeling of Processed Foods Among Mexican Consumers
Status: COMPLETED
Conditions: Food Labeling
Interventions: BEHAVIORAL: Guideline Daily Amounts|BEHAVIORAL: Multiple Traffic Light|BEHAVIORAL: Warning Labels|BEHAVIORAL: Video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Nutrition and Pharmacological Algorithm for Oncology Patients Study
Status: TERMINATED
Conditions: Oncologic Complications|Quality of Life|Nutrition Poor|Head and Neck Cancer|Lung Cancer|Pancreatic Cancer
Interventions: DRUG: Dexamethasone|DRUG: Dronabinol|DRUG: Mirtazapine|BEHAVIORAL: Nutrition Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gurney Journey: Virtual Reality Distraction
Status: RECRUITING
Conditions: Dental Caries in Children|Dental Diseases
Interventions: DEVICE: Standard Child Life Preparation and Support + Meta Quest 2 VR headset with Gurney Journey (a mixed reality experience)|BEHAVIORAL: Standard Child Life Preparation and Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Conventional Versus Posterior Approach in Ultrasound-Guided Parasagittal In-Plane Infraclavicular Brachial Plexus Block
Status: COMPLETED
Conditions: Brachial Plexus Block|Infraclavicular|Ultrasound Guided
Interventions: PROCEDURE: Posterior approach|PROCEDURE: Conventional approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking
Status: COMPLETED
Conditions: Bladder Cancer|Cervical Cancer|Esophageal Cancer|Gastric Cancer|Head and Neck Cancer|Kidney Cancer|Leukemia|Liver Cancer|Lung Cancer|Pancreatic Cancer|Tobacco Use Disorder
Interventions: DRUG: nicotine lozenge|DRUG: nicotine patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 48-Week, Randomised, Study to Describe the Pharmacokinetic Profile and Durability of Atazanavir-Saquinavir-Ritonavir Once Daily and Describe the Pharmacokinetic Profile of Saquinavir-Ritonavir Using Saquinavir 500mg Formulation: the ASK-500 Study
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: saquinavir 500 formulation|DRUG: cross-over arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial of Open Surgical vs. Rapid, Minimally-invasive Voluntary Adult Male Circumcision
Status: COMPLETED
Conditions: Circumcision
Interventions: PROCEDURE: Open surgical circumcision|DEVICE: Unicirc device with tissue adhesive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sarizotan HC1 in Patients With Parkinson's Disease Suffering From Treatment-associated Dyskinesia
Status: COMPLETED
Conditions: Parkinson's Disease|Dyskinesia
Interventions: DRUG: Sarizotan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection of Anti-glomerular Basement Membrane Antibodies (Anti-GBM): a Promising Biomarker for Lupus Nephritis (LN)?
Status: COMPLETED
Conditions: Lupus Nephritis
Interventions: OTHER: Detection of circulating anti-GBM antibodies (using chemiluminescence method and indirect immunofluorescence (IIF) method).
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Optimization of Pulmonary Rehabilitation Programmes: the OPTION Study
Status: TERMINATED
Conditions: COPD
Interventions: OTHER: Continuous high intensity training-CT80|OTHER: Training at ventilatory threshold-CTVT|OTHER: Interval training-IT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Platelet Aggregation in Diabetic Patients With Acute Coronary Syndrome Treated With Different Doses of Aspirin
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Diabetes Mellitus
Interventions: DRUG: aspirin 100 mg bis in die|DRUG: aspririn 200 mg once daily|DRUG: aspirin 100 mg once daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT