pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Comparison Study of Hypersensitivity Treatment
Status: COMPLETED
Conditions: Dentin Hypersensitivity
Interventions: DEVICE: 3M™ Clinpro™ Fluoride Aqueous Solution|DEVICE: 3M™ Vanish™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Low Dose Interleukin-2 in Patients With Stable Ischaemic Heart Disease and Acute Coronary Syndromes
Status: COMPLETED
Conditions: Ischemic Heart Disease
Interventions: DRUG: Proleukin|DRUG: Placebo Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of the Respirio Flu Test for the Rapid Identification of Influenza A/B
Status: COMPLETED
Conditions: Influenza A|Influenza B
Interventions: DEVICE: Respirio Flu Test|DEVICE: Reverse Transcriptase Polymerase Chain Reaction (RT-PCR)|DEVICE: Sofia® Influenza A+B Fluorescent Immunoassay (FIA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Antiviral Activity, and Pharmacokinetics of GSK2336805 With Peginterferon and Ribavirin in Chronic Hepatitis C Subjects
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: GSK2336805|DRUG: Pegylated interferon alfa-2a|DRUG: Ribavirin|DRUG: GSK2336805 Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Novel Recruitment Maneuver Therapy for Postoperative Pulmonary Atelectasis
Status: COMPLETED
Conditions: Postoperative Pulmonary Atelectasis
Interventions: OTHER: novel recruitment maneuver therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALX-0061 Phase I Bioavailability Study in Healthy Volunteers
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: ALX-0061|BIOLOGICAL: ALX-0061
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetic (PK), and Pharmacodynamic Study of GSK2881078 and Study to Evaluate the Effect of CYP3A4 Inhibition on PK of GSK2881078
Status: COMPLETED
Conditions: Cachexia
Interventions: DRUG: GSK2881078|DRUG: Placebo|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quality of Life Outcomes for Ulipristal Acetate and Tranexamic Acid in the Management of Heavy Menstrual Bleeding
Status: WITHDRAWN
Conditions: Heavy Menstrual Bleeding
Interventions: DRUG: UPA|DRUG: TEA|DRUG: Placebo (for UPA)|DRUG: Placebo (for TEA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Pharmacokinetics of an Inhibitor of Poly ADP-Ribose Polymerase-1 (PARP)
Status: COMPLETED
Conditions: Ovarian Neoplasms|BRCA1 Protein|BRCA2 Protein
Interventions: DRUG: KU-0059436 (AZD2281)(PARP inhibitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Risk-Adapted Therapy in Post-Pubertal Patients With Newly-Diagnosed Medulloblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Medulloblastoma
Interventions: DRUG: Sonidegib|DRUG: Cisplatin|DRUG: Lomustine|DRUG: Vincristine|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pilot Study of Ejaculatory Dyssynergia by Electronic Microsensors of Sphincters
Status: TERMINATED
Conditions: Spinal Cord Diseases|Disorder of Ejaculation
Interventions: PROCEDURE: Ejaculatory test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Lot-to-lot Consistency of 3 Lots of Tetravalent Dengue Vaccine (TDV) in Non-endemic Country(Ies) for Dengue
Status: COMPLETED
Conditions: Dengue Fever
Interventions: BIOLOGICAL: TAK-003|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ultrasound-enhanced Thrombolysis Versus Standard Catheter Directed Thrombolysis for Ilio-femoral Deep Vein Thrombosis
Status: COMPLETED
Conditions: Venous Thrombosis|Postthrombotic Syndrome
Interventions: PROCEDURE: CDT+US group|PROCEDURE: CDT-US group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Trial Estimating the Persistence of Molecular Remission in Chronic Myeloid Leukaemia in Long Term After Stopping Imatinib
Status: COMPLETED
Conditions: Chronic Myeloid Leukaemia
Interventions: DRUG: Imatinib stop
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study to Evaluate the Efficacy and Safety of TLC388 for Differentiated Neuroendocrine Carcinomas Patients
Status: COMPLETED
Conditions: Neuroendocrine Carcinomas
Interventions: DRUG: TLC 388
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Study Between Atovaquone and Antiretroviral Agents in HIV-1 Infected Patients
Status: COMPLETED
Conditions: HIV Infections|Malaria
Interventions: DRUG: Atovaquone / Proguanil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: OsciPulse Device for the Prevention of VTE
Status: COMPLETED
Conditions: Venous Thromboembolism|Deep Vein Thrombosis|Pulmonary Thromboembolisms
Interventions: DEVICE: OsciPulse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Ezetimibe and Fenofibrate in Patients With Mixed Hyperlipidemia (0653-036)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia|Hypertriglyceridemia
Interventions: DRUG: MK0653, ezetimibe|DRUG: Comparator: fenofibrate monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of PB127 Ultrasound Contrast Agent in Patients With Suspected Coronary Artery Disease 007
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: PB127 for injectable suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Urea Therapy for Hyponatremia in Subarachnoid Hemorrhage
Status: RECRUITING
Conditions: Hyponatremia|Subarachnoid Hemorrhage|SIADH
Interventions: DRUG: Urea|OTHER: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Incorporating Patient Treatment Choice to Improve Treatment Retention in Depressed Hispanics
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Antidepressants through Texas Medication Algorithm (TMA)|BEHAVIORAL: Brief Interpersonal Psychotherapy (IPT-B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brazilian Intervention to Increase Evidence Usage in Practice - Stroke (BRIDGE-Stroke)
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: BEHAVIORAL: Multifaceted Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Plaque Removal Efficacy & Patient Acceptability of Knotted Floss Technique in Type II Gingival Embrasures
Status: COMPLETED
Conditions: Oral Hygiene|Dental Devices, Home Care
Interventions: DEVICE: Knotted floss technique|DEVICE: Conventional flossing technique|DEVICE: Conventional Interdental Brushing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Retraining and Control Therapy (ReACT): Sense of Control and Symptom Expectations as Targets of a Treatment for PNES
Status: RECRUITING
Conditions: Convulsion, Non-Epileptic
Interventions: BEHAVIORAL: ReACT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: From the Biomedical to the Biopsychosocial Model, From Theory to Practice
Status: UNKNOWN
Conditions: Functional Dyspepsia
Interventions: PROCEDURE: Traditional Medical Consultation|PROCEDURE: Therapeutic Encounter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: AVocAdo Extract to Improve gLycemia in Individuals With Obesity (AVAIL)
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Avocado extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Safety and Efficacy of the Second Dose of Tranexamic Acid
Status: COMPLETED
Conditions: Tranexamic Acid
Interventions: DRUG: Tranexamic Acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Telehealth Delivery of Treatment for Sleep Disturbances in Young Children With Autism Spectrum Disorder
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism Spectrum Disorder|Sleep Disturbance
Interventions: BEHAVIORAL: Sleep Parent Training|BEHAVIORAL: Sleep Parent Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Effect of Mitomycin C 0.02% on the Corneal Endothelial After Photorefractive Keratectomy in Moderate Myopia
Status: UNKNOWN
Conditions: Myopia
Interventions: DRUG: Mitomycin C 0.02%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Effect of High Intensity Aerobic & Resistance Interval Training on Body Composition, Visceral Adiposity and Myocardial Function in Overweight and Obese Adults
Status: UNKNOWN
Conditions: Obesity
Interventions: OTHER: High intensity interval training|OTHER: Moderate Intensity Continuous Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Novel Anti-CD19 CAR-T in Patients With r/r B-Cell Malignancies
Status: RECRUITING
Conditions: B-Cell Leukemia|B-Cell Lymphoma|B-cell Tumors
Interventions: BIOLOGICAL: Anti-CD19 Autologous CAR-T Cell Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study to Evaluate the Effectiveness of Dexmedetomidine in Preventing Delirium After Hip Fracture Repair Surgery
Status: TERMINATED
Conditions: Delirium
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of Vertebral Fracture Risk for First Time Liver Transplant Candidates
Status: COMPLETED
Conditions: Metabolic Bone Disease|Transplant-Related Disorder|Secondary Osteoporosis
Interventions: DIAGNOSTIC_TEST: Dual x-ray absorptiometry|OTHER: Vertebral Fracture Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 4 Study to Evaluate the Efficacy, Safety, and Tolerability of Mirabegron in Male Subjects With Overactive Bladder (OAB) Symptoms, While Taking the Alpha Blocker for Benign Prostatic Hypertrophy (BPH)
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: Mirabegron|DRUG: Placebo|DRUG: Tamsulosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Anti-CD19 CAR-T Cell Immunotherapy for Refractory /Relapsed B Cell Malignancies
Status: UNKNOWN
Conditions: Acute Lymphocytic Leukemia|Chronic Lymphocytic Leukemia|Lymphoma
Interventions: COMBINATION_PRODUCT: Drugs and anti-CD19 CAR transduced T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Outcomes Between Rotator Cuff Repair With and Without Suprascapular Nerve Decompression
Status: ACTIVE_NOT_RECRUITING
Conditions: Rotator Cuff Tear
Interventions: PROCEDURE: Rotator Cuff Repair without Suprascapular Nerve decompression|PROCEDURE: Rotator Cuff Repair with Suprascapular Nerve decompression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Mature B-ALL and Burkitt Lymphoma (BL) in Adult Patients. BURKIMAB-14.
Status: UNKNOWN
Conditions: Mature B-Cell Leukemia Burkitt Type|Burkitt Lymphoma (BL)|Unclassifiable Lymphoma Between DCBL and BL
Interventions: DRUG: Rituximab|DRUG: Methotrexate|DRUG: Dexamethasone|DRUG: Iphosphamid|DRUG: Vincristine|DRUG: Etoposide|DRUG: Cytarabine|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vindesine|DRUG: Cytarabine|DRUG: Methotrexate|DRUG: Hydrocortisone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Control Trial of CO2 Laser to Treat Hypertrophic Burn Scar
Status: RECRUITING
Conditions: Burns|Hypertrophic Scar
Interventions: PROCEDURE: Luminis ultrapulse fractional ablative carbon dioxide laser|PROCEDURE: 0.5mm punch biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of "For-Baby" Supplementation on Young Children's Physical Growth and Diarrhea Episodes
Status: UNKNOWN
Conditions: Children|Malnutrition
Interventions: DIETARY_SUPPLEMENT: "For Baby "supplements provided as powder|DIETARY_SUPPLEMENT: Micronutrient powder provided as powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Clinical Efficiency of Photodynamic Therapy and Topical Corticosteroid in Treatment of Oral Lichen Planus
Status: COMPLETED
Conditions: Lichen Planus, Oral
Interventions: DRUG: Triamcinolone Acetonide|PROCEDURE: Photodynamic Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AZD2171 in Treating Patients With Locally Advanced Unresectable or Metastatic Liver Cancer
Status: TERMINATED
Conditions: Adult Primary Hepatocellular Carcinoma|Advanced Adult Primary Liver Cancer|Localized Unresectable Adult Primary Liver Cancer|Recurrent Adult Primary Liver Cancer
Interventions: DRUG: cediranib maleate|OTHER: laboratory biomarker analysis|PROCEDURE: computed tomography|PROCEDURE: dynamic contrast-enhanced magnetic resonance imaging|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contrast-Enhanced Ultrasonography in Diagnosing Early-Stage Ovarian Cancer in Patients With an Adnexal Mass Undergoing Surgery to Remove the Ovary
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Definity|OTHER: medical chart review
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Adding Voluntary Pelvic Floor Muscle Contraction to a Pilates Exercises Program
Status: COMPLETED
Conditions: Sedentary Lifestyle
Interventions: OTHER: Pilates Exercises program|OTHER: Pelvic floor muscle strength|OTHER: 3D perineal ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multidimensional Diagnostics and Effect of Activity Modification in Young Adolescents With Patellofemoral Pain
Status: COMPLETED
Conditions: Patellofemoral Pain Syndrome
Interventions: OTHER: Temporary activity modification and graded exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Suppression of the Pituitary-Ovarian Axis With Three Different Oral Contraceptive Regimens
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Seasonale [levonorgestrel (LNG)/ethinyl estradiol (EE)]|DRUG: Seasonique (LNG/EE and EE)|DRUG: Portia (LNG/EE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of Best PEEP (Positive End-expiratory Pressure) in Anesthetized Infants in Terms of Prevention of Atelectasis
Status: COMPLETED
Conditions: Pediatric Surgery
Interventions: PROCEDURE: applying PEEP3|PROCEDURE: applying PEEP6|PROCEDURE: applying PEEP9
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bioavailability of EPA/DHA in of Ruby-O and Krill Oil
Status: COMPLETED
Conditions: Bioavailability
Interventions: DIETARY_SUPPLEMENT: EPA + DHA Ruby-O|DIETARY_SUPPLEMENT: EPA + DHA Krill Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: F-Tryptophan PET/CT in Human Cancers
Status: RECRUITING
Conditions: Intracranial Glioma|Metastatic Brain Tumor|Breast Cancer|Neuroendocrine Tumors|Rectal Cancer
Interventions: DRUG: 1-(2-[18F]FLUOROETHYL)-L-Tryptophan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sympatholysis in Chronic Kidney Disease
Status: RECRUITING
Conditions: Chronic Kidney Disease
Interventions: DRUG: Sodium Bicarbonate|DRUG: Placebo|BEHAVIORAL: Exercise Training|BEHAVIORAL: Control to Exercise (Stretching)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Hepatic Impairment on the Pharmacokinetics of a Single Dose of TD-9855
Status: COMPLETED
Conditions: Symptomatic Neurogenic Orthostatic Hypertension|nOH
Interventions: DRUG: Ampreloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest of Myo-inositol Supplementation in Women With Polycystic Ovarian Syndrome
Status: RECRUITING
Conditions: Polycystic Ovary Syndrome|Reproductive Medicine
Interventions: DIETARY_SUPPLEMENT: Myo-Inositol + Levomefolic acid|DRUG: Clomiphene Citrate|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Drug-Drug Interaction of DWP16001 in Combination With Metformin in Healthy Male Adults (Phase 1 Study)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DWP16001|DRUG: Metformin IR|DRUG: DWP16001+Metformin IR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating the Efficacy and Safety of Insulin Degludec in Children and Adolescents With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin degludec|DRUG: insulin detemir|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NIF-Guided RAMIE Using ICG Versus OTE Feasibility RCT
Status: RECRUITING
Conditions: Esophageal Cancer
Interventions: PROCEDURE: Robotic Assisted Minimally Invasive Esophagectomy (RAMIE)|PROCEDURE: Open Transthoracic Esophagectomy (OTE)|DEVICE: Robotic Assisted Minimally Invasive Esophagectomy (RAMIE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Yangxinshi Pills on the Exercise Tolerance Compared With Trimetazidine in Patients After PCI
Status: UNKNOWN
Conditions: Percutaneous Coronary Intervention
Interventions: DRUG: Yangxinshi|DRUG: Trimetazidine|DRUG: Yangxinshi mimic|DRUG: Trimetazidine mimic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Myotensives Techniques, With and Without Auto-reeducation, on the Vital Capacity Forced by the Patient Affected by a Honeymoon Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: PROCEDURE: with self stretching same muscle|PROCEDURE: with self stretching of forearm muscles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ketogenic Diet in PCOS With Obesity and Insulin Resistance
Status: COMPLETED
Conditions: PCOS|Obesity|Insulin Resistance
Interventions: COMBINATION_PRODUCT: Very low calorie ketogenic diet|BEHAVIORAL: Low calorie standard diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optune(NOVOTTF-100A)+ Bevacizumab+ Hypofractionated Stereotactic Irradiation Bevacizumab-Naive Recurrent Glioblastoma (GCC 1344)
Status: TERMINATED
Conditions: RECURRENT GLIOBLASTOMA|Brain Tumor
Interventions: DEVICE: Optune(NOVOTTF-100A)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Celecoxib Through Surgery and Radiation Therapy for the Treatment of Advanced Head and Neck Cancer
Status: SUSPENDED
Conditions: Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Nasal Cavity and Paranasal Sinus Carcinoma|Oral Cavity Carcinoma|Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Pathologic Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Recurrent Hypopharyngeal Carcinoma|Recurrent Laryngeal Carcinoma|Recurrent Nasal Cavity and Paranasal Sinus Carcinoma|Recurrent Oral Cavity Carcinoma|Recurrent Oropharyngeal Carcinoma|Stage III Hypopharyngeal Carcinoma AJCC v8|Stage III Laryngeal Cancer AJCC v8|Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IV Hypopharyngeal Carcinoma AJCC v8|Stage IV Laryngeal Cancer AJCC v8|Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IVA Hypopharyngeal Carcinoma AJCC v8|Stage IVA Laryngeal Cancer AJCC v8|Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IVB Hypopharyngeal Carcinoma AJCC v8|Stage IVB Laryngeal Cancer AJCC v8|Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IVC Hypopharyngeal Carcinoma AJCC v8|Stage IVC Laryngeal Cancer AJCC v8|Stage IVC Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Interventions: DRUG: Celecoxib|OTHER: Placebo|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Role Of Fructose and Uric Acid In the Development of Obesity and Metabolic Syndrome
Status: COMPLETED
Conditions: Overweight and Obesity|Metabolic Syndrome|Hyperuricemia
Interventions: DIETARY_SUPPLEMENT: low fructose|DIETARY_SUPPLEMENT: Normal fructose arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Liposomal Doxorubicin (Lipo-Dox) in Patients With Brain Metastasis From Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Liposomal Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Empagliflozin on Liver Fat Content, Energy Metabolism and Body Composition in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes|Non-alcoholic Fatty Liver Disease
Interventions: DRUG: Empagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of BIIB033 (Opicinumab) as an Add-on Therapy to Disease-Modifying Therapies (DMTs) in Relapsing Multiple Sclerosis (MS)
Status: TERMINATED
Conditions: Multiple Sclerosis
Interventions: DRUG: BIIB033 (opicinumab)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ocular Comfort and OCT Observation of Post Lens Clearance and Ocular Tissue Compression
Status: COMPLETED
Conditions: Ocular Comfort
Interventions: DEVICE: Lotrafilcon A test contact lens|DEVICE: Lotrafilcon A control contact lens|DEVICE: Ultra-High Resolution Optical Coherence Tomographer (OCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Cerebellar Stimulation for Aphasia Rehabilitation
Status: RECRUITING
Conditions: Stroke
Interventions: DEVICE: Cathodal Cerebellar tDCS|BEHAVIORAL: Semantic Feature Analysis (SFA)|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 3D vs 2D HD Laparoscopy in Inguinal Hernia Repair
Status: COMPLETED
Conditions: Hernia, Inguinal
Interventions: PROCEDURE: 2D laparoscopic TAPP inguinal hernia repair|PROCEDURE: 3D laparoscopic TAPP inguinal hernia repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Veramyst on the Nasal and Ocular Symptoms of the Early Reaction to Nasal Challenge With Allergen
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: fluticasone furoate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Geriatric Anorexia Study 2.0
Status: COMPLETED
Conditions: Healthy|Frailty
Interventions: DEVICE: Wrist Actigraphy Device|DEVICE: Smart Body Weight Scale|DEVICE: Chair Scale|DEVICE: Handheld Body Fat Percentage Device|DEVICE: Bioelectric Impedance Analysis Scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reduced Port Laparoscopic Gastrectomy for Gastric Cancer
Status: RECRUITING
Conditions: Laparoscopic|Gastrectomy
Interventions: PROCEDURE: Reduced port laparoscopic gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of PEEP on Gastric Insufflation During Face Mask Induction of General Anesthesia in Children
Status: RECRUITING
Conditions: Anesthesia|Child
Interventions: OTHER: Positive End Expiratory Pressure PEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Research Study Looking at the Effect of Food Intake on How the Medicine NN0385-0434 Behaves in the Body of Healthy Participants
Status: COMPLETED
Conditions: Established Atherosclerotic Cardiovascular Disease (ASCVD) or ASCVD Risk|Elevated Cholesterol|Healthy Volunteers
Interventions: DRUG: NNC0385-0434
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Topical Minocycline Gel in Patients With Papulopustular Rosacea
Status: COMPLETED
Conditions: Rosacea|Papulopustular Rosacea
Interventions: DRUG: 1% Topical Minocycline Gel|DRUG: 3% Topical Minocycline Gel|OTHER: Topical Vehicle Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irreversible Electroporation(IRE) For Unresectable Portal Venous Tumor Emboli
Status: COMPLETED
Conditions: Liver Cancer
Interventions: PROCEDURE: Irreversible electroporation (IRE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Immunotherapy and Autologous Stem Cell Transplantation for Myeloma
Status: COMPLETED
Conditions: Myeloma
Interventions: BIOLOGICAL: Prevnar- Pneumococcal Conjugate Vaccine (PCV)|OTHER: Activated/costimulated autologous T-cell|DRUG: Revlamid® (Lenalidomide)|BIOLOGICAL: MAGE-A3/GM-GSF, Hiltonol® (Poly-ICLC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Leptin and Liver Enzymes Responses to Aerobic Training in Hepatitis c Patients
Status: UNKNOWN
Conditions: Hepatitis C
Interventions: BEHAVIORAL: aerobic treadmill exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Benzonatate Soft Capsule in Chinese Healthy Subjects
Status: UNKNOWN
Conditions: Cough
Interventions: DRUG: Group A: Benzonatate 100mg|DRUG: Group B: Benzonatate 200mg|DRUG: Group C: Benzonatate 400mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stepwise Heat-Denaturated Protein Introduction for Tolerance Induction in Food Allergy
Status: RECRUITING
Conditions: Food Allergy|Cow Milk Allergy
Interventions: OTHER: Implementation of cow's milk in decreasingly heated forms|OTHER: Implementation of heated cow's milk|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Single-dose Study in Healthy Japanese Male Adults to Evaluate Pharmacokinetics and Pharmacodynamics of E5501 5 mg Tablet (Study E5501-J081-015)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Group A: E5501 5mg, then 20mg, then 40 mg, then 5mg|DRUG: Group B: E5501 20mg, then 40mg, then 5 mg, then 5mg|DRUG: Group C: E5501 40mg, then 5mg, then 20 mg, then 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Discharge Stewardship in Children's Hospitals
Status: ENROLLING_BY_INVITATION
Conditions: Pneumonia, Bacterial|Pneumonia Childhood|Urinary Tract Infections|Soft Tissue Infections|Skin Infections|Community-acquired Pneumonia
Interventions: BEHAVIORAL: Discharge antibiotic stewardship intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Vaccine Therapy, GM-CSF, and Interferon Alfa-2b in Treating Patients With Locally Advanced or Metastatic Cancer That Expresses Carcinoembryonic Antigen (CEA)
Status: COMPLETED
Conditions: Adult Solid Neoplasm
Interventions: BIOLOGICAL: Recombinant Fowlpox-CEA(6D)/TRICOM Vaccine|BIOLOGICAL: Recombinant Interferon Alfa-2b|BIOLOGICAL: Recombinant Vaccinia-CEA(6D)-TRICOM Vaccine|BIOLOGICAL: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regeneration of Liver: Portal Vein Embolization Versus Radiofrequency Assisted Ligation for Liver Hypertrophy (REBIRTH)
Status: COMPLETED
Conditions: Liver Resection|Cancer
Interventions: PROCEDURE: Radiofrequency assisted liver partition with portal vein ligation (RALPP)|PROCEDURE: Portal vein embolization (PVE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise for Oncology Care Professionals
Status: NOT_YET_RECRUITING
Conditions: Burnout, Caregiver|Compassion Fatigue
Interventions: BEHAVIORAL: Circuit-based Resistance Training|BEHAVIORAL: Circuit-based Resistance Training + Home-based Walking|BEHAVIORAL: Home-based Walking
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate and Compare Injections of Autologous Dermal and Epidermal Cells Into the Balding Scalp of Subjects With Hair Loss (CA-0002013)
Status: COMPLETED
Conditions: Androgenetic Alopecia|Male Pattern Baldness|Female Pattern Baldness
Interventions: BIOLOGICAL: Autologous cultured dermal and epidermal cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking Either WHO Step I or Step II Analgesics or no Regular Analgesic
Status: COMPLETED
Conditions: Chronic Pain|Osteoarthritis
Interventions: DRUG: Tapentadol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DelIVery for Pulmonary Arterial Hypertension (PAH) & Continued Support Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Arterial Hypertension
Interventions: DEVICE: Model 10642 Implantable Intravascular Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders
Status: COMPLETED
Conditions: Fetal Alcohol Spectrum Disorders
Interventions: DRUG: Choline bitartrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Combining Personalized Neoantigen-based Dendritic Cell Vaccine With Microwave Ablation for the Treatment of Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma|Liver Cancer, Adult
Interventions: BIOLOGICAL: Neoantigen Vaccines|PROCEDURE: Microwave Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preference for Subutex® (Buprenorphine) Versus Suboxone® (Buprenorphine/Naloxone) in Opioid Dependent Patients on Subutex® (Study P05094)(COMPLETED)
Status: COMPLETED
Conditions: Opiate-related Disorders|Opiate Dependence|Drug Abuse
Interventions: DRUG: buprenorphine|DRUG: buprenorphine/naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Relative Bioavailability of Pegvisomant in Healthy Subjects
Status: COMPLETED
Conditions: Bioavailability
Interventions: DRUG: pegvisomant|DRUG: pegvisomant|DRUG: pegvisomant|DRUG: pegvisomant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lead Detoxifying Effects of Ascorbic Acid Among School Going Adolescents of Karachi- A Cluster Randomized Control Trial
Status: COMPLETED
Conditions: Elevated Blood Lead Levels
Interventions: DRUG: Ascorbic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Role of Cyclosporine in Blood Cell Transplants With T-Cell Add-Back for Blood Cancers
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Graft vs Host Disease|Hematologic Neoplasm|Multiple Myeloma|Myelodysplastic Syndrome
Interventions: DEVICE: Isolex 300i plus MoAbs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Stem Cell Transplants for Chronic Myelogenous Leukemia
Status: WITHDRAWN
Conditions: Leukemia
Interventions: DRUG: Busulfan|DRUG: Cyclophosphamide|DRUG: G-CSF|DRUG: GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer
Status: RECRUITING
Conditions: Oropharynx Cancer
Interventions: PROCEDURE: therapeutic conventional surgery|OTHER: laboratory biomarker analysis|OTHER: quality-of-life assessment|RADIATION: intensity-modulated radiation therapy|DRUG: Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Therapy and Growth Factor Ovarian in Vitro Activation
Status: UNKNOWN
Conditions: Menopause|Menopause Ovarian Failure|Ovarian Failure|Premature Ovarian Failure|Premature Ovarian Failure 1|Premature Ovarian Failure 2A|Premature Ovarian Failure 2B|Premature Ovarian Failure 3|Premature Ovarian Failure 4|Premature Ovarian Failure 5|Premature Ovarian Failure 6|Premature Ovarian Failure 7|Premature Ovarian Failure 8|Premature Ovarian Failure 9|Premature Ovarian Failure 10|Premature Ovarian Failure 11|Premature Ovarian Failure 12|Premature Ovarian Failure 13|Premature Ovarian Failure 14|Ovarian Insufficiency|Ovarian Failure Secondary|Ovarian Failure, Premature|Ovarian Insufficiency, Primary|Menopause, Premature
Interventions: COMBINATION_PRODUCT: SEGOVA procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PD-1 Inhibitor, Azacitidine and Low-dose DLI in AML Relapse After Allo-HSCT
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|BIOLOGICAL: Donor lymphocyte infusion|DRUG: Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Sapanisertib in Relapsed/Refractory NFE2L2-Mutated and Wild-Type Squamous Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer|Squamous Non-small-cell Lung Cancer|Squamous Non-Small Cell Neoplasm of Lung|NFE2L2 Gene Mutation
Interventions: DRUG: sapanisertib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PROVE ACURATE neo2™ - Post Market Safety and Performance Surveillance in Aortic Stenosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Stenosis
Interventions: DEVICE: Planned TAVI with the ACURATE neo2™ aortic bioprosthesis and ACURATE neo2™ transfemoral delivery system.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Correlation Between Duration of Fasting and Response to Fluid Replenishment, Evaluated With Repeated Measures of VTI.
Status: UNKNOWN
Conditions: Fluid and Electrolyte Imbalance|Fluid Therapy
Interventions: OTHER: Plasmalyte A Viaflo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Tirzepatide (LY3298176) in Participants With Nonalcoholic Steatohepatitis (NASH)
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis
Interventions: DRUG: Tirzepatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Succinate Metoprolol on Heart Rate in the Stable Angina Patients
Status: COMPLETED
Conditions: Angina Pectoris
Interventions: DRUG: Succinate Metoprolol (Betaloc ZOK®)|DRUG: Succinate Metoprolol (Betaloc ZOK®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MicroRNA Expression in Everolimus-based Versus Tacrolimus-based Regimens in Kidney Transplantation
Status: UNKNOWN
Conditions: microRNA Profiles
Interventions: DRUG: Everolimus|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Integrated Support and Palliative in Cancer Day-care Hospital for Patients With Advanced Cancers: Impact on Quality of Life, Care Pathways and Support for Caregivers (HDJ-SPI)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer, Advanced
Interventions: OTHER: Hospital day care follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Getting in Balance: A Workplace Diabetes Prevention Intervention Trial
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Overweight|Obesity
Interventions: BEHAVIORAL: In-Person Diabetes Prevention Program|BEHAVIORAL: Online Diabetes Prevention Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Internet-based CBT vs. TAU for Stress-related Disorders
Status: ACTIVE_NOT_RECRUITING
Conditions: Adjustment Disorders|Exhaustion Disorder
Interventions: BEHAVIORAL: Internet-based cognitive behavior therapy|BEHAVIORAL: Internet-based structured treatment-as-usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Intratumoral G100 With Or Without Pembrolizumab or Rituximab In Participants With Follicular Non-Hodgkin's Lymphoma (MK-3475-174/IMDZ-G142)
Status: TERMINATED
Conditions: Follicular Low Grade Non-Hodgkin's Lymphoma
Interventions: DRUG: G100|DRUG: Pembrolizumab|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0011, Gene Therapy & Surgery Followed by Chemo & RT in Newly Diagnosed Cancer of the Mouth or Throat
Status: TERMINATED
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: Ad5CMV-p53 gene|DRUG: cisplatin|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ADDICTOlogical Intervention in LIVEr Transplantation Recipients
Status: NOT_YET_RECRUITING
Conditions: Alcohol Associated Liver Disease|Liver Transplantation
Interventions: OTHER: Post-transplant addiction intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Peds Sanofi H1N1 Influenza Vaccine Administered at Two Dose Levels
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza Virus Vaccine, Monovalent A/H1N1 A/California/7/2009 NYMC X-179A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, Pharmacokinetics, Immunogenicity and Efficacy of STP705 in Adult Patients With Hypertrophic Scars
Status: NOT_YET_RECRUITING
Conditions: Hypertrophic Scar
Interventions: DRUG: STP705
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Pressurized Irrigation an Effective Alternative to Swabbing for Wound Cleansing?
Status: COMPLETED
Conditions: Acute and Chronic Wounds
Interventions: PROCEDURE: Pressurized irrigation method|PROCEDURE: Swabbing wound cleansing method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluating the Effectiveness of Adding Rituximab to Standard Treatment for Thrombotic Thrombocytopenic Purpura (TTP)
Status: TERMINATED
Conditions: Thrombotic Thrombocytopenic Purpura
Interventions: DRUG: Rituximab|PROCEDURE: Plasma exchange|DRUG: Corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RFA Versus SBRT for Recurrent Small HCC
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: RADIATION: stereotactic body radiotherapy (SBRT)|PROCEDURE: Radiofrequency ablation (RFA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a New Daily Disposable Multifocal Contact Lens Design
Status: COMPLETED
Conditions: Presbyopia|Hyperopia|Refractive Error
Interventions: DEVICE: Delefilcon A multifocal contact lenses|DEVICE: Lotrafilcon B multifocal contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT