pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of Brentuximab Vedotin in Relapsed or Refractory Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Lymphoma, B-Cell|Lymphoma, Large B-Cell, Diffuse|Lymphoma, Non-Hodgkin|Lymphoma, T-Cell
Interventions: DRUG: brentuximab vedotin|DRUG: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Continuous Hepatic Arterial Infusion With Floxuridine (FUDR) and Dexamethasone (DEX) in Patients With Unresectable Primary Hepatic Malignancy
Status: COMPLETED
Conditions: Hepatic Cancer
Interventions: DRUG: FLOXURIDINE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Left Atrial Appendage Occlusion vs. Usual Care in Patients With Atrial Fibrillation and Severe Chronic Kidney Disease
Status: TERMINATED
Conditions: Blood Coagulation Disorders|Atrial Fibrillation|Thrombosis of Left Atrial Appendage|Chronic Kidney Disease Stage 4|Chronic Kidney Disease Stage 5
Interventions: DEVICE: Left atrial appendage occlusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety Assessment of T4090 Eye Drops in Ocular Hypertensive or Glaucomatous Patients.
Status: ACTIVE_NOT_RECRUITING
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: Kinezodianone R hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of External Pressure Applı̇ed to the Palm on Labor Paı̇n and Childbirth Experı̇ence
Status: COMPLETED
Conditions: Labor Pain
Interventions: PROCEDURE: External pressure to the palm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TiVi Evaluation of Microcirculatory Reactivity of the Skin to Galvanic Stimulation: Effect of Aspirin
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: TiVi system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for Pain Control After Elective Caesarean Section
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Standard therapy|DEVICE: Verum acupuncture|OTHER: Placebo acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Ta1 for Sepsis
Status: COMPLETED
Conditions: Sepsis
Interventions: DRUG: Thymosin alpha 1|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Health Education Programme for Prevention of Chronic Migraine: A Randomized Clinical Trial
Status: COMPLETED
Conditions: Chronic Migraine
Interventions: OTHER: A health education programme using a telerehabilitation platform
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Mycophenolate Mofetil 500 mg Tablets of Dr.Reddy's Laboratories Limited Under Non-Fasting Conditions
Status: COMPLETED
Conditions: FED
Interventions: DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Techniques for Scaling and Root Planing and One Stage Full Mouth Disinfection
Status: COMPLETED
Conditions: Periodontal Disease|Chronic Periodontitis
Interventions: PROCEDURE: Scaling and root planing|PROCEDURE: Full mouth disinfection|DRUG: Chlorhexidine gel and gluconate|DRUG: Chlorhexidine gluconate solution|DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effect of an Additional 5 Minutes Pumping on Milk Output in the First Days After Delivery
Status: COMPLETED
Conditions: Breast Pumping
Interventions: DEVICE: 15 minutes pumping with INITIATE program|DEVICE: 5 minutes extra pumping with MAINTAIN program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treating Social Cognition With Theta Burst Stimulation; a Pilot Sudy
Status: UNKNOWN
Conditions: Social Cognition in Patients With Schizophrenia
Interventions: DEVICE: Active TBS|DEVICE: Sham TBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rifabutin Therapy for the Prevention of Mycobacterium Avium Complex (MAC) Bacteremia in AIDS Patients With CD4 Counts = or < 200: A Double-Blind, Placebo-Controlled Trial
Status: COMPLETED
Conditions: Mycobacterium Avium-intracellulare Infection|HIV Infections
Interventions: DRUG: Rifabutin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Cancer of Esophagogastric Junction: Optimized Sweet Versus Ivor-Lewis
Status: RECRUITING
Conditions: Esophagogastric Junction Carcinoma
Interventions: PROCEDURE: Esophagectomy by Ivor-Lewis Procedure|PROCEDURE: Esophagectomy by Optimized Sweet Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of 311-nm Ti:Sapphire Laser Versus 308-nm Excimer Laser Treatment in Vitiligo
Status: UNKNOWN
Conditions: Vitiligo
Interventions: DEVICE: 311-nm Ti:Sapphire laser|DEVICE: 308-nm excimer laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screening Tool for Malnutrition, Sarcopenia, and Cachexia
Status: COMPLETED
Conditions: Malnutrition|Sarcopenia|Cachexia
Interventions: OTHER: Ain Shams University Screening Tool for Malnutrition, Sarcopenia, and Cachexia (ASUST-MSC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Real-world Evidence With SGLT2i (Dapagliflozin) and DPP4i (Sitagliptin) in Type 2 Diabetes Patients in Spain
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Dapagliflozin|DRUG: Sitagliptin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Smoking Cessation Intervention for American Indian Women Experiencing Intimate Partner Violence
Status: RECRUITING
Conditions: Smoking Cessation|Cigarette Smoking
Interventions: BEHAVIORAL: Healing Within: Smoking Cessation Intervention for American Indian Women Experiencing Intimate Partner Violence
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of OGTT in Patients With Post-pancreatitis Diabetes Mellitus for Diagnosis and Characterization
Status: RECRUITING
Conditions: Chronic Pancreatitis|Pancreatogenic Type 3C Diabetes Mellitus|Diabetes Mellitus|Oral Glucose Tolerance Test
Interventions: DIAGNOSTIC_TEST: blood test|DEVICE: Continuous Glucose Monitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: rTMS for Emotional Difficulties in Verterans
Status: COMPLETED
Conditions: Mental Health|Depression|rTMS|Anxiety|PTSD|Psychosocial Impairment
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Noisome as A Carrier of Locally Delivered Minocycline Hydrochloride Gel
Status: NOT_YET_RECRUITING
Conditions: Periodontitis
Interventions: DRUG: Minocycline hydrochloride with noisome carrier|DRUG: Minocycline Hydrochloride only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prazosin Augmentation of Outpatient Treatment of Alcohol Use Disorders in Active Duty Soldiers With and Without PTSD
Status: COMPLETED
Conditions: Alcohol Use Disorders|Stress Disorders, Posttraumatic|Combat Disorders
Interventions: DRUG: prazosin hydrochloride|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of CHG Regimen vs Decitabine to Treat Higher-risk MDS
Status: UNKNOWN
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: CHG regimen|DRUG: 5-aza-deoxycytidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insulin Fiasp vs. Insulin Novorapid During Pregnancy and Laction in Women With Pre-existing Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus|Pregnancy Complications
Interventions: DRUG: Faster-acting Aspart insulin Fiasp|DRUG: Control (insulin Novorapid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Silymarin Cream Versus Salicylic Acid in Treatment of Acne Vulgaris
Status: UNKNOWN
Conditions: Acne Vulgaris
Interventions: COMBINATION_PRODUCT: Silymarin|PROCEDURE: Salicylic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Torrent Pharmaceutical Ltd.'s Zolpidem Tartrate Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Zolpidem Tartrate Tablets 10 mg|DRUG: 'Sanofi-Synthelabo Inc's Ambien® Tablets 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Innovative Physiotherapy in Stroke Rehabilitation
Status: COMPLETED
Conditions: Stroke, Ischemic|Stroke Hemorrhagic
Interventions: PROCEDURE: ICoreDIST|PROCEDURE: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Gemigliptin in Type 2 Diabetes Who Have Inadequate GlycemIc Control With Dapagliflozin and Metformin (SOLUTION Study)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Gemigliptin 50mg|DRUG: Gemigliptin Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PGE2 Levels in Patient Treated With NSAIDs
Status: COMPLETED
Conditions: Ocular Inflammation
Interventions: OTHER: Placebo|DRUG: Dicloftil|DRUG: Nevanac|DRUG: Indom|DRUG: Yellox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Medico-economical Impact of the Brindley Neurosurgical Technique in France
Status: COMPLETED
Conditions: Spinal Cord Injuries|Neurogenic Bladder Disorder|Paraplegia|Quadriplegia
Interventions: DEVICE: Brindley technique (bladder system)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Olaparib in Combination With Carboplatin for Refractory or Recurrent Women s Cancers
Status: COMPLETED
Conditions: Ovarian Cancer|Breast Cancer|Primary Peritoneal Cancer|Fallopian Tube Cancer|Endometrial Cancer
Interventions: DRUG: Carboplatin|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurolens Headache Study
Status: COMPLETED
Conditions: Binocular Vision Disorder|Convergence Insufficiency|Headache|Computer Vision Syndrome
Interventions: DEVICE: Neurolens spectacle lens|DEVICE: Placebo spectacle lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sugemalimab as Consolidation Therapy in Patients With LS-SCLC Following cCRT or sCRT
Status: RECRUITING
Conditions: Limited Stage Small Cell Lung Cancer
Interventions: DRUG: Sugemalimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms
Status: RECRUITING
Conditions: Opioid Use Disorder|Back Pain|Stress
Interventions: DRUG: Placebo|DRUG: Oxycodone|DRUG: Naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Sedoanalgesia and General Anaesthesia on Early Neurological Recovery in Acute Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Ischemic Stroke|Anesthesia|Neurologic Symptoms
Interventions: PROCEDURE: Sedoanalgesia|PROCEDURE: general anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3015014 in Participants With High Cholesterol
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: LY3015014|DRUG: Placebo|DRUG: Statin|DRUG: Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: School-based Paraeducator Education for Engagement at Recess
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Neurodevelopmental Disorders
Interventions: BEHAVIORAL: Remaking Recess|OTHER: TEAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Comparison of Collagen, Lidocaine and Saline, in Trigger Points in Masseter Muscle.
Status: COMPLETED
Conditions: Temporomandibular Disorder
Interventions: DRUG: MD Muscle GUNA collagen|DRUG: Lidocaine 2% Injectable Solution|DRUG: Saline Solution, Hypertonic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Examining Alcohol Consumption, Perceptions, and User Experience of Alcohol Moderation Strategies
Status: COMPLETED
Conditions: Alcohol Abuse|Alcohol Use Disorder|Alcohol Abuse, Episodic
Interventions: OTHER: Alcohol Moderation Mobile Application|BEHAVIORAL: Alcohol Moderation Drink Tracker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Dry Needling on Neck and Shoulder Pain in Orchestral Musicians: a Prospective Case Series
Status: COMPLETED
Conditions: Pain Syndrome|Musculoskeletal Pain|Trigger Point Pain, Myofascial
Interventions: PROCEDURE: Deep dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observation Study in Patients Age 0-5 Years With LAMA2-related Congenital Muscular Dystrophy
Status: NOT_YET_RECRUITING
Conditions: LAMA2-MD \(Merosin Deficient Congenital Muscular Dystrophy, MDC1A\)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A New 360° Dual-task Based Protocol for the Pre-clinical In-hospital and At-home Rehabilitation of Elderly: DUAL-Rehab
Status: RECRUITING
Conditions: Cognitive Decline
Interventions: DEVICE: 360° media|OTHER: Treatment As Usual (TAU)|OTHER: In hospital sessions|OTHER: at home sessions|OTHER: Mild Cognitive Impairment|OTHER: Subjective Memory Complain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Double-Blind, Randomized, Cross-Over Trial of Aged Garlic Extract for Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Aged garlic extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nitrocamptothecin in Treating Patients With Recurrent or Metastatic Ovarian Epithelial or Primary Peritoneal Cancer
Status: WITHDRAWN
Conditions: Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: rubitecan
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer
Status: NOT_YET_RECRUITING
Conditions: Melanoma
Interventions: DRUG: Cobolimab|DRUG: Dostarlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pediatric Patients
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Letermovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Patients With Mild Coronavirus-19 (COVID-19) Disease With Methotrexate Associated to LDL Like Nanoparticles (Nano-COVID19)
Status: UNKNOWN
Conditions: Coronavirus|Inflammation|Covid19
Interventions: DRUG: Methotrexate-LDE phase 1|DRUG: Methotrexate-LDE phase 2|DRUG: Placebo-LDE phase 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Autologous CIK Cell Immunotherapy Combination With PD-1 Inhibitor and Chemotherapy in the Advanced NSCLC
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer|First-line Treatment
Interventions: BIOLOGICAL: CIK cell|BIOLOGICAL: Sintilimab Injection|DRUG: Pemetrexed|DRUG: Liposome paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study of IG3018 in Subjects With Hyperuricemia With or Without Chronic Kidney Disease
Status: NOT_YET_RECRUITING
Conditions: Hyperuricemia|Hypouricemia, Renal
Interventions: DRUG: IG3018|OTHER: Placebo matching IG3018
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treadmill Training in Fragile X-associated Tremor/Ataxia Syndrome
Status: TERMINATED
Conditions: Fragile X Associated Tremor-ataxia Syndrome
Interventions: BEHAVIORAL: Dual-Task Treadmill exercise + Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Keeping Well:Online Cognitive Behavioral Therapy (CBT) for Pregnant Women With Depressive Symptoms
Status: WITHDRAWN
Conditions: Anxiety|Mental Disorders|Postpartum Depression|Depressive Symptoms
Interventions: BEHAVIORAL: Online Cognitive Behavioral Therapy (CBT)|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Ablation Study for trEatment of atRial Fibrillation (LASER)
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Laser ablation|DEVICE: RF ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of MEDI9314 as Single Ascending Dose in Healthy Subjects
Status: COMPLETED
Conditions: Safety|Healthy Subjects
Interventions: DRUG: MEDI9314|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intercontinental Multidisciplinary Registry and Treatment Optimization Study for Choroid Plexus Tumors
Status: TERMINATED
Conditions: Brain Cancer|Choroid Plexus Tumors
Interventions: DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Cyclophosphamide|DRUG: Dactinomycin|DRUG: Doxorubicin|DRUG: Etoposide|DRUG: Irinotecan|DRUG: Leucovorin|DRUG: Methotrexate|DRUG: Temozolomide|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Circulating Tumor DNA Methylation Guiding Postoperative Adjuvant Chemotherapy in Stage III Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: ctDNA methylation|DIAGNOSTIC_TEST: standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Modulation of Ciliogenesis in Glioma Stem Cells
Status: RECRUITING
Conditions: Glioblastoma|Glioma, Malignant
Interventions: OTHER: Biological sample collection|OTHER: Dissecting ciliogenesis players|DIAGNOSTIC_TEST: Validating ciliogenesis players
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: What Determines a Positive Outcome of Spinal Manipulation for Persistent Low Back Pain: Stiffness or Pain Sensitivity? A Randomized Trial
Status: COMPLETED
Conditions: Low Back Pain|Pain, Chronic
Interventions: OTHER: Spinal manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Short- and Long-term 'Blackboard' Intervention on Ankle Stability in Older Adults
Status: COMPLETED
Conditions: Fall
Interventions: OTHER: Specific ankle stability exercises|OTHER: Conventional physiotherapy exercises program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Washed Microbiota Transplantation for Patients With 2019-nCoV Infection
Status: WITHDRAWN
Conditions: COVID-19 Complicated With Refractory Intestinal Infections
Interventions: OTHER: washed microbiota transplantation|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cytidine-phosphate-guanosine (CpG) DNA in Hepatocellular Carcinoma Combination Therapy
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: CpG DNA|PROCEDURE: transcatheter arterial chemoembolization|DRUG: Placebo - Concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quetiapine Extended Release (XR) for the Management of Psychotic Aggression or Agitation in Adult Acute Psychiatry
Status: UNKNOWN
Conditions: Schizophrenia|Psychosis
Interventions: DRUG: Quetiapine XR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Congenital Heart Anomaly Risk in Maternal Enteroviral Infection and Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Congenital Heart Disease|Viremia|Virus Diseases|Enterovirus|Enterovirus Infections|Heart Defects, Congenital|Heart Diseases|Prenatal Infection|Diabetes|Diabetes Mellitus, Type 2|Diabetes Mellitus, Type 1|Diabetes Mellitus|Pregnancy in Diabetic|Pregnancy Complications|Prenatal
Interventions: OTHER: Stool and Blood Specimen Collection|OTHER: Follow-up Medical Record Review
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Transdiagnostic Behavioral Therapy for Anxiety and Depression in Autistic Adolescents
Status: ACTIVE_NOT_RECRUITING
Conditions: Anxiety|Depression|Emotional Disorder|Autism
Interventions: BEHAVIORAL: Transdiagnostic cognitive behavioral therapy (CBT)|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sedation Efficacy of Dexmedetomidine Versus Midazolam in Critically Ill Ventilated Children
Status: RECRUITING
Conditions: Mechanically Ventilated, Critically Ill Children
Interventions: DRUG: Precedex|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain
Status: UNKNOWN
Conditions: Cancer|Pain|Palliative Care
Interventions: DRUG: Methadone plus Acetaminophen or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Irinotecan-based Triplet (FOLFOXIRI) as Perioperative Treatment in Resectable Gastric and Gastroesophageal Junction Adenocarcinoma.
Status: ACTIVE_NOT_RECRUITING
Conditions: Resectable Gastric and Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Fluorouracil|DRUG: Oxaliplatin|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TB-CAPT EXULTANT - HIV
Status: RECRUITING
Conditions: Tuberculosis|HIV Coinfection|Diagnoses Disease
Interventions: DIAGNOSTIC_TEST: Concentrated urine with Xpert Ultra|DIAGNOSTIC_TEST: Stool with Xpert Ultra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparing Anticoagulation Strategies Using UFH, Argatroban and LMWH for ECMO Support
Status: RECRUITING
Conditions: Respiratory Insufficiency|Circulatory Failure|Thromboembolism|Bleeding
Interventions: DRUG: Enoxaparin Injectable Solution|DRUG: Argatroban, 1 Mg/mL Intravenous Solution|DRUG: Unfractionated heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study in HCV-Infected Patients to Determine the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of JNJ-47910382
Status: TERMINATED
Conditions: Chronic Hepatitis C Infection
Interventions: DRUG: Placebo|DRUG: JNJ-47910382
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Robot-assisted Invasion-controlled Surgery Versus Traditional-open Surgery Against Metastatic Spinal Tumor
Status: UNKNOWN
Conditions: Minimally Invasive Surgery|Spinal Metastases
Interventions: PROCEDURE: Robot-assisted Invasion-controlled Surgery|PROCEDURE: Traditional-open Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dosage of Metformin on Menstruation and Lipid Profile in Women With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Metformin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Platelet Rich Plasma vs. Corticosteroid Injections for Treating Greater Trochanteric Pain Syndrome
Status: UNKNOWN
Conditions: Greater Trochanteric Pain Syndrome
Interventions: DRUG: Triamcinolone Acetonide|OTHER: Platelet Rich Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Understanding the Response to Fesoterodine Through Genetic Evaluation in the Elderly (URGE)
Status: COMPLETED
Conditions: Urge Urinary Incontinence
Interventions: DRUG: Fesoterodine Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Cardioprotective Effects of Adding Ozone To Cardioplegic Solution in Adult Cardiac Surgery
Status: UNKNOWN
Conditions: Ischemic Heart Disease
Interventions: DRUG: Ozone|DRUG: Cardioplegic Solutions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: AC220 for Children With Relapsed/Refractory ALL or AML
Status: COMPLETED
Conditions: Lymphoblastic Leukemia, Acute, Childhood|Myelogenous Leukemia, Acute, Childhood
Interventions: DRUG: AC220|DRUG: Cytarabine|DRUG: Etoposide|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Architectural and Performance Adaptations of Hip Extension Exercise Under Gravitational or Inertial Loading Conditions
Status: COMPLETED
Conditions: Injury;Sports
Interventions: OTHER: Hip extension exercise with inertial load|OTHER: Hip extension exercise with gravitational load
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Prolonged Continuous Theta Burst Stimulation on Pain and Neural Excitability
Status: NOT_YET_RECRUITING
Conditions: pcTBS|Pain
Interventions: DEVICE: pcTBS of M1|DEVICE: SHAM stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Fluid Management by SVV of FloTrac/ Vigileo™ Monitoring on Postoperative Recovery in Bowel Resection
Status: COMPLETED
Conditions: Bowel Resection
Interventions: DEVICE: Conventional arterial blood pressure monitoring|DEVICE: Stroke volume variation monitoring with arterial blood pressure monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impact of Timing of Midazolam Administration on Incidence of Postoperative Nausea and Vomiting
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Midazolam injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Identification of New Genetic Markers of Risk of Venous Thromboembolism Recurrence by Analyzing Whole Genome
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: BIOLOGICAL: Extra Blood Draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Blood Flow Restriction and High-intense Resistance Training in Aging: Interactions Between Neuroplasticity and Muscle
Status: COMPLETED
Conditions: Aging|Cognitive Decline|Sarcopenia|Frailty|Muscle Degeneration|Physical Disability
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Fasting Study - Unraveling the Mechanistic Effects of Prolonged Fasting in Humans.
Status: COMPLETED
Conditions: Fasting|Adipose Tissue|Clinical Trial|Lipid Metabolism
Interventions: OTHER: Fasting for 26-hours
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Hydrolyzed pine nut oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reduced-visit Antenatal Care Model
Status: ENROLLING_BY_INVITATION
Conditions: Antenatal Care|Telehealth Services
Interventions: BEHAVIORAL: Online antenatal care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Community Based Health Education for Prevention of Pelvic Floor Dysfunction in Fertile Women in Rural China
Status: ACTIVE_NOT_RECRUITING
Conditions: Pelvic Floor Dysfunction
Interventions: BEHAVIORAL: Health education intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Effect of Back Massage on ınfertılıty Stress, Sexual satısfactıon and marrıage Harmony ın ınfertılıty Couples
Status: COMPLETED
Conditions: Sexual Activity|Infertility|Stress
Interventions: OTHER: back massage|OTHER: no ıntervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Probiotic on Immunogenicity of Oral Cholera Vaccine
Status: COMPLETED
Conditions: Cholera
Interventions: BIOLOGICAL: Whole cell killed cholera vaccine & probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Genetics of Evoked Responses to Niacin and Endotoxemia: The GENE Study
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Immediate Release Niacin, Extended Release Niacin, Endotoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Gut Microbiota Diversity in Children Aged 1-3 Years on Prolonged Antibiotic Prophylaxis for Grade 3 or Higher Vesicoureteral Reflux Compared With 2 Age-matched Control Groups
Status: RECRUITING
Conditions: Vesicoureteral Reflux 3
Interventions: OTHER: Stool sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Human Papillomavirus (HPV) Vaccine (GSK580299) in Healthy Female Subjects 10-25 Years of Age.
Status: COMPLETED
Conditions: Human Papillomavirus (HPV) Infection
Interventions: BIOLOGICAL: Cervarix|DRUG: Placebo Al(OH)3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Compare the Efficacy of Human Albumin With Cabergoline to Prevent Ovarian Hyper Stimulation in Assisted Reproductive Technology (ART) Program
Status: COMPLETED
Conditions: Ovarian Hyperstimulation Syndrome
Interventions: DRUG: Cabergoline|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Non-pharmacological Methods in Pain Managment During Heel Stick in Preterm Infants
Status: COMPLETED
Conditions: Pain, Acute|Neonatal Intensive Care Unit
Interventions: PROCEDURE: Breast milk odor group|PROCEDURE: Facilitated tucking group|PROCEDURE: Non-nutritive sucking group|PROCEDURE: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Early Versus Late Initiation of Anticoagulation in Mild-to-moderate AIS Patients With NVAF
Status: RECRUITING
Conditions: Acute Ischemic Stroke|Atrial Fibrillation
Interventions: DRUG: Anticoagulation Agents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Anti PD-1 Immunotherapy in Resectable Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-centre Study of Shoe-worn Insoles and Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Lateral wedge insoles (LWIs)|DEVICE: Lateral wedge plus custom arch support (LWAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Effectiveness of a Polymer Cerclage System Compared to Cerclages Used in Standard Care (CERCPMCF) )
Status: RECRUITING
Conditions: Femoral Fracture
Interventions: DEVICE: Implantation of Ortholoop cerclage|DEVICE: Implantation of Cerclage used in current practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Health4Kids Intervention Trial for Hispanic Families
Status: COMPLETED
Conditions: Pediatric Obesity
Interventions: BEHAVIORAL: behavioral counseling|OTHER: Education Materials|BEHAVIORAL: Face to face counseling session|BEHAVIORAL: Text messages|BEHAVIORAL: Telephone Counseling|BEHAVIORAL: Newsletters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bortezomib Plus Dexamethasone for Acquired Pure Red Cell Aplasia Failure or Relapse After First-line Treatment
Status: TERMINATED
Conditions: Acquired Pure Red Cell Aplasia
Interventions: DRUG: bortezomib/dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Theta-burst Stimulation for Major Depression: an Intensity-response Study
Status: RECRUITING
Conditions: Depression, Unipolar
Interventions: DEVICE: intermittent theta-burst stimulation (iTBS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Docosahexaenoic Acid Supplementation on Biomarkers of Concussion Over the Course of a Year in Canadian National Rugby Players
Status: COMPLETED
Conditions: Head Trauma
Interventions: DIETARY_SUPPLEMENT: Docosahexaenoic Acid (DHA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Taurine in Peripartum Cardiomyopathy
Status: COMPLETED
Conditions: Peripartum Cardiomyopathy
Interventions: DRUG: Taurine Solution|DIETARY_SUPPLEMENT: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Identification of Surrogate Blood and/or Urine Biomarker for Immulina TM (Trademark) in Normal Humans
Status: COMPLETED
Conditions: Adherence, Patient
Interventions: DIETARY_SUPPLEMENT: Immulina
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy Study to Evaluate Buprenorphine HCl Buccal Film in Opioid-Experienced Subjects
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: Buprenorphine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: OneDoc Picopulse™ for the Treatment of Melasma Among Malaysian Women
Status: COMPLETED
Conditions: Skin Diseases|Skin Disorder|Melanoma (Skin)
Interventions: DEVICE: OneDoc Picopulse
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Circadian Rhythm of ICU Patients With Acute Myocardial Infraction and the Effect of Light Therapy
Status: RECRUITING
Conditions: Circadian Dysrhythmia|Delirium
Interventions: DEVICE: Blue light therapy|OTHER: White light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Nanocurcumin on Serum Oxidative Stress,Inflammation,Adiponectin and NF-kB in Blood Mononuclear Cells in Metabolic Syndrome Patients (Nuclear Factor-κB)
Status: UNKNOWN
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: nanomicielle curcumin|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Memantine and Sodium Oligomannate in Patients With Moderate to Severe Alzheimer's Disease
Status: NOT_YET_RECRUITING
Conditions: Treatment|Efficacy|Safety|Alzheimer Disease
Interventions: DRUG: Memantine Oral Tablet|DRUG: GV-971 capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Video-Assisted Self-Assessment on Nasogastric Tube Insertion
Status: RECRUITING
Conditions: Nurse's Role
Interventions: BEHAVIORAL: Experimental (Video-Assisted Self-Assessment on Nasogastric Tube Insertion)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Paths to Everyday Life (PEER) - a Community-based Peer Support Intervention
Status: COMPLETED
Conditions: Mental Health Impairment|Peer Group|Mental Health Disorder|Problems Psychosocial
Interventions: BEHAVIORAL: Paths to everyday life (PEER)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Randomized, Controlled Study of CF Patients Between 3 Months and Less Than 7 Years
Status: COMPLETED
Conditions: Treatment of Early Pulmonary Infections With P. Aeruginosa in Cystic Fibrosis Patients
Interventions: DRUG: TOBI|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Volunteers
Status: COMPLETED
Conditions: Surgery
Interventions: DRUG: Chlorhexidine gluconate|DRUG: DynaHex-2|OTHER: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy, Safety and Acceptability of the New Pen Needle 34gx3,5mm.
Status: UNKNOWN
Conditions: Diabetes Mellitus
Interventions: DEVICE: Insupen G34x3,5mm|DEVICE: Insupen G32x4mm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY900014 in Participants With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: LY900014|DRUG: Insulin Lispro|DRUG: Insulin Glargine|DRUG: Insulin Degludec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Hafnia Alvei on Weight Loss and Glycaemic Control After Bariatric Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Hafnia alvei HA4597™|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Recognition of Pulmonary Arterial Hypertension in Myelodysplastic and Myeloproliferative Diseases
Status: COMPLETED
Conditions: Myeloproliferative Disorder|Myelodysplastic Syndromes|Pulmonary Hypertension
Interventions: OTHER: echocardiography, right heart catheterisation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Patient Satisfaction During Outpatient Versus Inpatient Foley Catheter Induction of Labor
Status: ACTIVE_NOT_RECRUITING
Conditions: Induction of Labor Affected Fetus / Newborn|Cervical Ripening|Patient Satisfaction
Interventions: OTHER: Outpatient Cervical Ripening|OTHER: Inpatient Cervical Ripening|PROCEDURE: Foley catheter placement|BEHAVIORAL: Pre-Foley Questionnaire|BEHAVIORAL: Post-Foley Questionnaire|PROCEDURE: Fetal Non-Stress Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Using Parent Engagement to Improve the Wellbeing of Black Premature Infants With Lung Disease
Status: NOT_YET_RECRUITING
Conditions: Chronic Lung Disease
Interventions: BEHAVIORAL: P-CGS (Pediatric Collaborative Goal Setting)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of REGN3500 Monotherapy and Combination of REGN3500 Plus Dupilumab in Adult Patients With Moderate-to-Severe Atopic Dermatitis
Status: TERMINATED
Conditions: Atopic Dermatitis
Interventions: DRUG: REGN3500|DRUG: Dupilumab|DRUG: REGN3500 + Dupilumab Combo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT