pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of an Oral Nutritional Supplement on Muscle Mass During Anticancer Treatment
Status: RECRUITING
Conditions: Colorectal Cancer (CRC)|Non-small Cell Lung Cancer (NSCLC)
Interventions: DIETARY_SUPPLEMENT: an enriched high protein and high energy oral nutrition supplement (ONS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Wii Fit as Balance Assessment and Training
Status: COMPLETED
Conditions: Healthy Young Adults
Interventions: OTHER: balance-specific -games focusing on dynamic aspects of COP on Wii fit system.|OTHER: mini trampoline and inflatable discs group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transverse Abdominus Plane Block Study
Status: WITHDRAWN
Conditions: Colorectal Disorders|Surgery
Interventions: COMBINATION_PRODUCT: Ropivacaine, Dexmedetomidine, Dexamethasone sodium phosphate, Normal saline|DRUG: Liposomal bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Abdominal Plane Blocks (APB) in Chronic Abdominal Pain (CAP)
Status: COMPLETED
Conditions: Abdominal Pain|Abdominal Myofascial Pain Syndrome (AMPS)|Abdominal Plane Blocks (APB)
Interventions: PROCEDURE: Abdominal Plane Block(s) with depot Steroids
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Effect of ACT-774312 in Subjects With Bilateral Nasal Polyposis
Status: COMPLETED
Conditions: Bilateral Nasal Polyposis
Interventions: DRUG: ACT-774312|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Vertical Inter-implant Papilla Height in Platform Matched Implants in Comparison to Morse Connection Abutments
Status: RECRUITING
Conditions: Interimplant Mucosa
Interventions: COMBINATION_PRODUCT: Morse connection Implants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Fatty and Lean Fish Intake on Cardiovascular Risk Factors in Subjects With Coronary Heart Disease
Status: COMPLETED
Conditions: Blood Pressure|Arrhythmia|Inflammation
Interventions: OTHER: Dietary intervention|OTHER: Dietary intervention|OTHER: Dietary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myo-inositol for Reduction of Insulin Therapy in Gestational Diabetes Mellitus
Status: RECRUITING
Conditions: Gestational Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Myo Inositol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extended Cancer Education for Longer-Term Survivors in Primary Care for Patients With Stage I-II Breast or Prostate Cancer or Stage I-III Colorectal Cancer
Status: COMPLETED
Conditions: Stage I Breast Cancer|Stage I Colorectal Cancer AJCC v6 and v7|Stage I Prostate Cancer|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage II Breast Cancer|Stage II Colorectal Cancer AJCC v7|Stage II Prostate Cancer|Stage IIA Breast Cancer|Stage IIA Colorectal Cancer AJCC v7|Stage IIA Prostate Cancer|Stage IIB Breast Cancer|Stage IIB Colorectal Cancer AJCC v7|Stage IIB Prostate Cancer|Stage IIC Colorectal Cancer AJCC v7|Stage III Colorectal Cancer AJCC v7|Stage IIIA Colorectal Cancer AJCC v7|Stage IIIB Colorectal Cancer AJCC v7|Stage IIIC Colorectal Cancer AJCC v7
Interventions: OTHER: Informational Intervention|OTHER: Internet-Based Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|BEHAVIORAL: Telephone-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Determine Optimal Time for Delivering Electrical Shocks to Cardiac Arrest Patients
Status: COMPLETED
Conditions: Cardiac Event|Sudden Cardiac Death|Death|Ventricular Fibrillation|Ventricular Tachycardia
Interventions: DEVICE: Upstroke Compression Defibrillation|DEVICE: Precompression Defibrillation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Zilucoplan® in Improving Oxygenation, Short-, Longterm Outcome of COVID19 Patients With Acute Hypoxic Respiratory Failure
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Zilucoplan®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Optimization for Safe and Efficient Fluorescein Angiography (DOSE Study)
Status: COMPLETED
Conditions: Retinal Disease
Interventions: DRUG: Fluorescein Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Intervention Effect of Shen-based Qigong Exercise on Residual Symptoms of Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: OTHER: daily rehabilitation interventions|OTHER: shen-based Qigong exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of KUS121 in Participants With Acute Non-Arteritic Central Retinal Artery Occlusion (CRAO)
Status: RECRUITING
Conditions: Central Retinal Artery Occlusion
Interventions: DRUG: KUS121 high dose|DRUG: KUS121 low dose|DRUG: Sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Intersectional Stigma Among High-Risk Women in Brazil to Promote Uptake of HIV Testing and PrEP
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Prevention
Interventions: BEHAVIORAL: Manas por Manas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: TMC278-TiDP6-C153 - A Study in Healthy Volunteers Investigating the Pharmacokinetic Interaction Between TMC278 and Raltegravir
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: TMC278|DRUG: Raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sintilimab Combined With Regorafenib and HAIC in Patients With Colorectal Liver Metastasis
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer|Liver Metastasis
Interventions: DRUG: HAIC|DRUG: Sintilimab|DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Endurance Exercise and Histamine Receptors on the Gene Expression in Skeletal Muscle
Status: COMPLETED
Conditions: Exercise|Histamine
Interventions: DRUG: Placebo: Placebo + exercise training.|DRUG: H1 blockade: H1 receptor antagonist + exercise training|DRUG: H2 Blockade: H2 receptor antagonist + exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Turnover of Antigen Specific Lymphocytes and Monocytes After Immunization With the 17D Yellow Fever Vaccine
Status: COMPLETED
Conditions: Yellow Fever
Interventions: BIOLOGICAL: Yellow fever vaccine|OTHER: Deuterium (70% enriched 2H2O) labeled water
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prevention of Irinotecan Induced Diarrhea by Probiotics
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: Probiotic formula|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Copanlisib in Combination With Standard Immunochemotherapy in Relapsed Indolent Non-Hodgkin's Lymphoma (iNHL)
Status: TERMINATED
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: Copanlisib (BAY80-6946)|DRUG: Placebo|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Bendamustine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk Factors for Exertional Heat Illness
Status: RECRUITING
Conditions: Exertional Heat Illness
Interventions: OTHER: Core temperature monitoring|BEHAVIORAL: Questionnaires|OTHER: Heart rate monitoring|OTHER: Urine collection|OTHER: Sleep monitoring|OTHER: Blood collection|OTHER: Saliva collection|OTHER: Throat swab collection|OTHER: Stool collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A 10-week Efficacy Study of NOE-105 in Childhood Onset Fluency Disorder (Orpheus)
Status: COMPLETED
Conditions: Childhood-Onset Fluency Disorder
Interventions: DRUG: NOE-105|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Methotrexate Withdrawal Study of Tofacitinib Modified Release Formulation in Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: CP-690,550|DRUG: Methotrexate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Effect of Orange Juice Mixed With Oat β-Glucan on Bioavailability of Polyphenols in Healthy Individuals
Status: UNKNOWN
Conditions: Healthy
Interventions: OTHER: Orange Juice|OTHER: Orange juice with either 6g or 3 g of β-Glucan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of the Fixed Combinations of Brimonidine/Timolol and Dorzolamide/Timolol in Subjects With Open-Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: brimonidine tartrate 0.2%/timolol maleate 0.5% fixed combination|DRUG: dorzolamide hcl 2%/timolol maleate 0.5% fixed combination|DRUG: brimonidine tartrate 0.2%/timolol maleate 0.5% fixed combination as adjunctive to current prostaglandin therapy|DRUG: dorzolamide hcl 2%/timolol maleate 0.5% fixed combination as adjunctive to current prostaglandin therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Placebo-Controlled Dose-Escalation Study to Determine the Safety and Efficacy of Intravenous Infusion of Human Placenta-Derived Cells (PDA001) for the Treatment of Crohn's Disease
Status: COMPLETED
Conditions: Crohns Disease
Interventions: BIOLOGICAL: PDA001|DRUG: Vehicle Controlled Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating ALLN-177 for Reducing Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria
Status: COMPLETED
Conditions: Hyperoxaluria|Nephrolithiasis
Interventions: DRUG: ALLN-177
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mainz Register of Patients With Sleep Disorders
Status: RECRUITING
Conditions: Sleep Disorder|Sleep Disorder Parasomnia|Narcolepsy|Sleep Apnea|Insomnia|Somnambulism|Idiopathic Hypersomnia|Restless Legs Syndrome|REM Behavior Disorder
Interventions: DEVICE: Implantation of vagus nerve stimulation according to clinical indication
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant Depression
Status: COMPLETED
Conditions: Depressive Disorder, Treatment-Resistant
Interventions: DRUG: Esketamine 56 mg|DRUG: Esketamine 84 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Post-licensure Safety Surveillance Study of Menactra Vaccine When Administered As a 2-dose Schedule to Children
Status: COMPLETED
Conditions: Meningitis|Meningococcal Infection
Interventions: BIOLOGICAL: Menactra®: Meningococcal Polysaccharide Diphtheria Toxoid Conjugate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enzastaurin Plus Fulvestrant vs. Placebo Plus Fulvestrant in Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: enzastaurin|DRUG: placebo|DRUG: fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Buzzy® Device on the Prevention of Health Care Induced Pediatric Pain in a Vaccination Center
Status: COMPLETED
Conditions: Intravenous Injections|Vaccination
Interventions: DEVICE: Buzzy® device|DRUG: EMLAPATCH (lidocaine, prilocaine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Intravenous Iron Treatment of Preoperative Anemia in Patients With LEAD (IRONPAD)
Status: RECRUITING
Conditions: Anemia|Peripheral Arterial Occlusive Disease
Interventions: DRUG: Ferric Carboxymaltose Injection [Injectafer]|OTHER: no treatment or oral iron supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Randomized, Blinded, Dose-escalation Study of rAAV1-PG9DP Recombinant AAV Vector Coding for PG9 Antibody in Healthy Male Adults.
Status: UNKNOWN
Conditions: HIV Infections
Interventions: BIOLOGICAL: rAAV1-PG9DP|BIOLOGICAL: rAAV1-PG9DP|BIOLOGICAL: rAAV1-PG9DP|BIOLOGICAL: rAAV1-PG9DP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Addition of Oral Montelukast to Standard Treatment in Acute Moderate to Severe Asthma in Children
Status: COMPLETED
Conditions: Bronchial Asthma
Interventions: DRUG: montelukast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Positive Airway Pressure and Acetazolamide to Treat Sleep Apnea Syndrome Patients at Altitude
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndrome
Interventions: DRUG: acetazolamide|PROCEDURE: nocturnal continuous positive airway pressure|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Family Violence and Alcohol and Drug Misuse in Sri Lanka
Status: COMPLETED
Conditions: Intimate Partner Violence|Domestic Abuse|Drug and Alcohol Abuse
Interventions: BEHAVIORAL: Capacity building to support families affected by IPV & substance misuse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Real-life Clinical Outcomes of Direct Oral Anticoagulants (MACACOD)
Status: RECRUITING
Conditions: Atrial Fibrillation|Recurrent Venous Thromboembolism
Interventions: DRUG: dabigatran, rivaroxaban, apixaban or edoxaban
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of Insulin Resistance, NAFLD, Predictors of CV Morbidity, and Subcutaneous Adipose and Visceral Adipose Gene Expression in Patients Undergoing Gastric Bypass Surgery
Status: COMPLETED
Conditions: Morbid Obesity|Insulin Resistance|Non-Alcoholic Fatty Liver Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of PCUR-101 in Combination With ADT in Patients With mCRPC
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: PCUR-101|DRUG: Dutasteride 0.5 mg|DRUG: Abiraterone and Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Interleukin (IL)-1 in Postprandial Fatigue - The Chäschüechli 2 Study
Status: COMPLETED
Conditions: Adiposity
Interventions: DRUG: Anakinra|DRUG: NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Surgical Techniques in Diabetes Mellitus-II and Obesity. Metabolic Surgery Study (MSS)
Status: UNKNOWN
Conditions: Diabetes Mellitus|Obesity
Interventions: PROCEDURE: Gastric bypass|PROCEDURE: Modified gastric bypass.|PROCEDURE: Slevee Gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Catheter Ablation Compared With Pharmacological Therapy for Atrial Fibrillation (CAPTAF Trial)
Status: UNKNOWN
Conditions: Atrial Fibrillation|Quality of Life
Interventions: DEVICE: Catheterablation|DRUG: Amiodarone|DRUG: Sotalol|DRUG: Flecainide|DRUG: Propafenone|DRUG: Disopyramide|DRUG: Dronedarone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Dose Pharmacokinetics of Suboxone Study in Hepatic Impaired Subjects
Status: COMPLETED
Conditions: Hepatic Failure|Hepatic Impairment|Chronic Hepatitis C Infection With Hepatic Coma
Interventions: DRUG: 2.0mg Buprenorphine/0.5mg Naloxone|DRUG: Promethazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization of Therapeutic Human Serum Albumin Infusion in Selected Critically Ill Patients
Status: TERMINATED
Conditions: Shock|Systemic Inflammatory Response Syndrome (SIRS)|Hypoalbuminaemia
Interventions: DRUG: Human serum albumin infusion 4%|DRUG: Human serum albumin infusion 20%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability and Efficacy of Cannabidiol (CBD) as a Steroid-sparing Therapy in Chronic Spontaneous Urticaria (CSU) Patients
Status: COMPLETED
Conditions: Chronic Spontaneous Urticaria
Interventions: DRUG: CBD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Management of Fistulas Related to Sleeve Gastrectomy With Double Pigtail Stents According to the BARTOLI Technique
Status: COMPLETED
Conditions: Gastrostomy|Fistula
Interventions: PROCEDURE: endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Breathing Exercise on Sleep and Stress Levels in Women With Breast Cancer Receiving Chemotherapy Treatment
Status: RECRUITING
Conditions: Women Receiving Chemotherapy|18 Years of Age and Above|Women With High Stress Levels|Women With Poor Sleep Quality
Interventions: OTHER: Breathing exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Brivanib and Best Supportive Care to Placebo for Treatment of Liver Cancer for Those Subjects Who Have Failed Sorafenib Treatment
Status: COMPLETED
Conditions: Liver Cancer
Interventions: DRUG: Brivanib|OTHER: Placebo|PROCEDURE: Best Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Warm Humid Gas Insufflation for Appendix Removal by Minimally Invasive Surgery Warm Humid Insufflation for Appendix Removal by Minimally Invasive Surgery Trial (WARMIST)
Status: UNKNOWN
Conditions: Peritoneal Dessication Damage and Inflammation|Peri-operative Hypothermia
Interventions: DEVICE: Fisher and Paykel Insuflow (MR 860) Surgical Humidification Device|PROCEDURE: Laparoscopic Appendicectomy|PROCEDURE: Laparoscopic Appendicectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Facilitating Use of the National Suicide Prevention Lifeline in Alcohol Patients (Reach Out)
Status: RECRUITING
Conditions: Suicide|Alcohol Use Disorder
Interventions: BEHAVIORAL: Crisis Line Facilitation (CLF)|BEHAVIORAL: Enhanced Usual Care (EUC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Brimonidine Tartrate/Ketotifen Fumarate Combination in Adults With Seasonal Allergic Conjunctivitis
Status: COMPLETED
Conditions: Seasonal Allergic Conjunctivitis
Interventions: DRUG: Brimonidine Tartrate 0.025%/ Ketotifen Fumarate 0.035% Ophthalmic Solution|DRUG: Ketotifen fumarate ophthalmic solution 0.035% (n = 56)|DRUG: Brimonidine tartrate ophthalmic solution 0.025% (n = 56)|DRUG: Experimental: Vehicle ophthalmic solution (n = 56)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Pertuzumab + Trastuzumab + Docetaxel Versus Placebo + Trastuzumab + Docetaxel in Previously Untreated Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: Pertuzumab|DRUG: Placebo|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Liraglutide and Glimepiride on Blood Sugar Control in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: placebo|DRUG: liraglutide|DRUG: glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Efficacy, Safety, Tolerability, and Biomarkers of MN-166 (Ibudilast) in Patients Hospitalized With COVID-19 and at Risk for ARDS
Status: COMPLETED
Conditions: Pneumonia, Viral
Interventions: DRUG: Ibudilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PEG-ASP+Gemox Regimen and Thalidomide for NK/T Lymphoma
Status: UNKNOWN
Conditions: Extranodal NK-T-Cell Lymphoma, Nasal and Nasal-Type
Interventions: DRUG: pegaspargase|DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Methotrexate|DRUG: Dexamethasone|DRUG: Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protein Fermentation Unraveled (PROFUN) - Exploring the Relationship Between Digestibility and Metabolite Production
Status: COMPLETED
Conditions: Protein Fermentation
Interventions: COMBINATION_PRODUCT: Protein digestibility
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Validation of the TOF Cuff Monitor® Which Measures Neuromuscular Block on the Upper Arm
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: DEVICE: Tof cuff|DEVICE: Tof Watch SX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Investigation of a Novel Gene Expression Test (ASGES or Corus CAD) for Diagnosis of Obstructive Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease|Angina Pectoris|Chest Pain|Cardiovascular Diseases|Coronary Heart Disease|CAD|CVD|CHD
Interventions: DIAGNOSTIC_TEST: Corus CAD (ASGES)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Physical Capacity in Hodgkin Lymphoma Survivors
Status: UNKNOWN
Conditions: Hodgkin Lymphoma, Adult|Cardiovascular Diseases|Radiation Effect|Chemotherapy Effect
Interventions: PROCEDURE: Physical Characteristics|DIAGNOSTIC_TEST: Assessment of Heart rate variability|DIAGNOSTIC_TEST: Blood Pressure and Cardiac Autonomic Control|DIAGNOSTIC_TEST: Evaluation of Baroreflex Control|DIAGNOSTIC_TEST: Cardiac Function and Structure|DIAGNOSTIC_TEST: Assessment of Coronary Anatomy and Calcium Score|DIAGNOSTIC_TEST: Blood Assessments|DIAGNOSTIC_TEST: Physical Capacity|PROCEDURE: Physical Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ipilimumab, Ibrutinib, and Nivolumab for the Treatment of Chronic Lymphocytic Leukemia and Richter Transformation
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Recurrent Chronic Lymphocytic Leukemia|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Small Lymphocytic Lymphoma|Richter Syndrome
Interventions: DRUG: Ibrutinib|BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: iTBS for Adolescent Depression: An Open Label Study Evaluating Safety and Efficacy of Treatment
Status: COMPLETED
Conditions: Depression
Interventions: DEVICE: iTBS Device/Motor Threshold Coil|DEVICE: iTBS Device/Treatment Coil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing Bowel Preparation and Patient Tolerability of Miralax Versus Golytely
Status: UNKNOWN
Conditions: Colonoscopy
Interventions: DRUG: Golytely (polyethylene glycol)|DRUG: MiraLax (polyethylene glycol 3350)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Single-Center, Double-Blind (DB) Study of MEM 3454 on P50 Sensory Gating and Mismatch Negativity in Schizophrenia Patients
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DRUG: MEM 3454|DRUG: MEM 3454|DRUG: MEM 3454|DRUG: MEM 3454|DRUG: Placebo for MEM 3454
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Rising Dose Study With Intravenous Infusion and Subcutaneous Injection of BI 1005273 in Healthy Male Volunteers.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1005273 s.c.|DRUG: BI 105273 i.v. Placebo|DRUG: BI 1005273 s.c. Placebo|DRUG: BI 1005273 i.v.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Remote Ischaemic Preconditioning to Prevent Dialysis Induced Cardiac Injury
Status: TERMINATED
Conditions: Hemodialysis|Cardiovascular Diseases
Interventions: OTHER: Remote Ischaemic Preconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regional Anesthesia Block of the Transversus Abdominis Plane in Children Undergoing Gastric Tube Insertion
Status: TERMINATED
Conditions: Anesthesia|Enteral Nutrition
Interventions: PROCEDURE: bupivacaine with epinephrine (mid and upper abdomen)|PROCEDURE: bupivacaine with epinephrine (transversus abdominis plane)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Short-term Interventions for a Healthy Lifestyle on the Human Lipidome in Subjects With Metabolic Syndrome
Status: UNKNOWN
Conditions: Metabolic Syndrome|NAFLD|Obesity|Hypertension
Interventions: BEHAVIORAL: Lifestyle intervention (physical activity)|DIETARY_SUPPLEMENT: Lifestyle intervention (PUFA/isomaltulose-enriched muffin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effects of Acute Ketone Monoester Supplementation on Exercise Efficiency and the Influence of Dose and Intensity
Status: COMPLETED
Conditions: Exercise|Ketosis
Interventions: DIETARY_SUPPLEMENT: Ketone monoester|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bioavailability of Human Milk Oligosaccharides in Healthy Adults
Status: RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Human Milk Oligosaccharides (HMOs)|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Advanced Cardiovascular Imaging of the Systemic Effects of Inflammasome Activation
Status: NOT_YET_RECRUITING
Conditions: Myocardial Infarction
Interventions: DRUG: Dapansutrile|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immediate Impact of Lumbar Fascia Stretching on Hamstring Flexibility
Status: COMPLETED
Conditions: Hamstring Injury
Interventions: OTHER: Treatment of the lumbar fasciae|OTHER: Placebo intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intraocular Pressure (IOP) Patterns in Fast Versus Slow Visual Field (VF) Progression Patients
Status: TERMINATED
Conditions: Primary Open-angle Glaucoma (POAG) Patient
Interventions: DEVICE: SENSIMED Triggerfish®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: FES-Rowing Versus Zoledronic Acid to Improve Bone Health in Spinal Cord Injury (SCI)
Status: TERMINATED
Conditions: Osteoporosis
Interventions: OTHER: FES-Rowing|DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Surgical Treatment of Patients With Ischemic Cardiomyopathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases|Chronic Heart Failure|Ischemic Cardiomyopathy
Interventions: PROCEDURE: coronary artery bypass graft (CABG) with surgical ventricular restoration (SVR) and mitral repair (MR)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The ATLET Study: Can Subjects With Incomplete Spinal Cord Injury Learn to Walk?
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: OTHER: Locomotor training with robot|OTHER: Locomotor training with manual assistance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Anesthesia Versus Erector Spina Plane Block
Status: COMPLETED
Conditions: Inguinal Hernia Repair|Postoperative Pain|Peripheral Nerve Blocks
Interventions: PROCEDURE: İnguinal Hernia Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Pharmacogenomic Study of Monotherapy Erbitux in Subjects With Metastic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apixaban Prevents Portal Vein Thrombosis After Laparoscopic Splenectomy and Azygoportal Disconnection
Status: COMPLETED
Conditions: Cirrhosis|Splenectomy|Venous Thrombosis|Hypertension, Portal
Interventions: DRUG: Apixaban 2.5 MG|DRUG: Dipyridamole 25Mg Tab|DRUG: subcutaneous Low Molecular Weight Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bone Marrow Aspirate Concentrate Use in Hip Osteoarthritis
Status: TERMINATED
Conditions: Osteoarthritis, Hip
Interventions: PROCEDURE: BMAC/PRP Injection|PROCEDURE: Cortisone Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability, and Efficacy of Rocatinlimab in Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: Rocatinlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 0.5M Na Lactate Solution in Acute Heart Failure (AHF)
Status: COMPLETED
Conditions: Acute Heart Failure
Interventions: DRUG: 0.5M Sodium lactate|DRUG: Hartmann's solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Teriparatide, Vibration and the Combination on Bone Mass and Bone Architecture in Chronic Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury|Bone Loss|Osteoporosis
Interventions: DRUG: Teriparatide|DEVICE: vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of GPO Seasonal Tetravalent Inactivated Split Virion Influenza Vaccine in Healthy Thais
Status: ACTIVE_NOT_RECRUITING
Conditions: Influenza
Interventions: BIOLOGICAL: TetraFluvac TF vaccine|BIOLOGICAL: Vaxigrip vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Variability In Mixed Meal Tests: Fixed Versus Adjusted to Energy Needs Caloric Dose
Status: RECRUITING
Conditions: Obesity|Healthy Volunteer
Interventions: OTHER: Fixed Mixed Meal Test|OTHER: Adjusted Mixed Meal Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Self-administration of Medication During Hospitalization on Medication Safety, Adherence, and Patient Satisfaction in Dutch Hospitals
Status: TERMINATED
Conditions: Medication Safety|Patient Safety|Patient Empowerment
Interventions: BEHAVIORAL: Self-administration of medication (SAM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Protection From Cisplatin Ototoxicity by Lactated Ringers
Status: WITHDRAWN
Conditions: Hearing Loss
Interventions: DRUG: Normal Saline and 0.3% ofloxacin|DRUG: Lactated Ringer's with 0.03% Ofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Long-term Lipid-lowering Therapy in STEMI Patients With Coronavirus Infection COVID-19
Status: ACTIVE_NOT_RECRUITING
Conditions: STEMI|Covid19|NSTEMI
Interventions: DRUG: Atorvastatin 80mg|DRUG: Atorvastatin-Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sunitinib + Docetaxel as Second-line Treatment in Gastric Cancer
Status: COMPLETED
Conditions: Advanced Gastric Cancer
Interventions: DRUG: Docetaxel + Sunitinib|DRUG: Docetaxel only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment With the Ketone Body 3-hydroxybutyrate in Patients With Acute Heart Failure
Status: UNKNOWN
Conditions: Acute Heart Failure
Interventions: DIETARY_SUPPLEMENT: HVMN Ketone Ester|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Predicting Dysglycemia in Individuals With Gestational Diabetes Immediately Postpartum Using Continuous Glucose Monitoring
Status: RECRUITING
Conditions: Gestational Diabetes|Prediabetes; Complicating Pregnancy|Type 2 Diabetes|Pregnancy Related|Glucose Metabolism Disorders|Metabolic Disease|Endocrine System Diseases
Interventions: DEVICE: Freestyle Libre 2|DEVICE: Freestyle Libre 2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Benefit of the SALAD Technique on CPR Quality During Intubation in Contaminated Airway
Status: COMPLETED
Conditions: Airway Aspiration|Cardiopulmonary Arrest
Interventions: DEVICE: SALAD intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Retrospective Observational Study on the Effects of Probiotics on HBsAg Clearance
Status: RECRUITING
Conditions: Chronic Hepatitis B
Interventions: DRUG: PegIFNα2b|DRUG: PegIFNα2b+probiotics|DRUG: Nucleoside analog|DRUG: Nucleoside analog+probiotics
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of HNC042 in Healthy Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetics.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HNC042 single dose|DRUG: Placebo single dose|DRUG: HNC042 multiple ascending doses|DRUG: Placebo multiple ascending doses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficiency Study of S-Tenatoprazole-Na to Treat Erosive or Ulcerative Esophagitis
Status: SUSPENDED
Conditions: Esophagitis, Reflux
Interventions: DRUG: S-Tenatoprazole-Na (STU-Na)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Switch to Doravirine/Islatravir (DOR/ISL) in Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Who Are Virologically Suppressed on Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) (MK-8591A-052)
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV-1 Infection
Interventions: DRUG: DOR/ISL|DRUG: BIC/FTC/TAF|DRUG: Placebo to BIC/FTC/TAF|DRUG: Placebo to DOR/ISL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single and Multiple Ascending Dose Study for NKTR-118 and Cross-over Study to Investigate the Effect of Food for NKTR-118 in Japanese Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: NKTR-118|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Olaparib + Sapacitabine in BRCA Mutant Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Sapacitabine|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Video Information on Preoperative Anxiety in Patients With Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer|Video Information
Interventions: OTHER: Short video clip including the circumstance of operation theater, and surgeon's interview
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Novel Compound for Alcoholism Treatment: A Translational Strategy - Part II
Status: TERMINATED
Conditions: Alcoholism
Interventions: DRUG: PF-05190457|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assess the Safety, Tolerability Oral PU-H71 in Subjects Taking Ruxolitinib
Status: TERMINATED
Conditions: Primary Myelofibrosis (PMF)|Post-Polycythemia Vera Myelofibrosis (Post-PV MF)|Post-Essential Thrombocythemia Myelofibrosis (Post-ET MF)
Interventions: DRUG: PU-H71
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Inspiratory Muscle and Endurance Training in Heart Failure Patients With Pacemaker
Status: COMPLETED
Conditions: Pacemaker
Interventions: DEVICE: Inspiratory muscle strength training|DEVICE: Inspiratory muscle endurance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Investigate Salivary Flow and Potential of Hydrogen (pH) Following Use of Essential-Oil Containing Mouthwashes
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Listerine Clinical Solutions Teeth Strength|DRUG: Listerine Total Care Zero Alcohol Mouthwash|OTHER: Listerine Cool Mint Zero Alcohol Mouthwash|DRUG: Colgate Cavity Protection Toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study on the Efficacy of Disitamab Vedotin in Advanced HER2-positive Paget's Disease.
Status: NOT_YET_RECRUITING
Conditions: Mammary or Extramammary Paget's Disease
Interventions: DRUG: RC48
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Branched-chain Amino Acid Supplementation for Hepatocellular Carcinoma
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma|Cirrhosis|Liver Failure
Interventions: DRUG: Branch Chain Amino Acid|OTHER: maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: S-Caine™ Peel (Skin Numbing Cream) to Treat Pain During Vascular Access Procedures in Children
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: S-Caine™ Peel (lidocaine and tetracaine cream 7%/7%)|DRUG: Placebo Peel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hand Transplantation: Functional and Quality of Life Outcomes
Status: WITHDRAWN
Conditions: Amputation; Traumatic, Arm, Upper, Between Shoulder and Elbow|Amputation; Traumatic, Hand|Amputation; Traumatic, Hand, Both|Amputation; Traumatic, Arm: Forearm, at Elbow Level|Amputation; Traumatic, Arm, Upper
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Boric Acid vs. Terconazole in Treatment of RVVC
Status: UNKNOWN
Conditions: Vulvovaginal Candidiasis
Interventions: DRUG: Boric Acid Vaginal Suppository|DRUG: Terconazole Vaginal Suppository
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Micro and Macro Circulation in Sepsis
Status: RECRUITING
Conditions: Sepsis|Septic Shock
Interventions: DIAGNOSTIC_TEST: Starling Stroke Volume (Starling SV)- Passive Leg Raise|DIAGNOSTIC_TEST: Microscan Sublingual Microscopy|DIAGNOSTIC_TEST: Venous Excess Ultrasound Scoring (VExUS)|OTHER: Urine Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Diet and Fasting for Long COVID
Status: ACTIVE_NOT_RECRUITING
Conditions: Long Covid19|Long COVID
Interventions: OTHER: Low sugar diet and 10-12 hour eating window|OTHER: Low sugar diet, 8 hour eating window and fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Study With E-DO in Chronic Hand Dermatitis
Status: COMPLETED
Conditions: Chronic Hand Dermatitis
Interventions: OTHER: E-DO|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Bilateral Gamma Knife Thalamotomy in Patients Presenting With Severe Essential Tremor
Status: COMPLETED
Conditions: Patients With Parkinson's Disease
Interventions: DEVICE: Gamma Knife® radiosurgery bilateral
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Early Bactericidal Activity and Safety in Pulmonary Tuberculosis With WX-081
Status: COMPLETED
Conditions: Pulmonary Tuberculosis
Interventions: DRUG: WX-081|DRUG: Bedaquiline|DRUG: Standard treatment|DRUG: Multi-drug background treatment (MBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT