pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A First in Human Study to Assess the Safety, Tolerability and Immunogenicity of a Single Dose of a Trivalent Inactivated Poliovirus Vaccine Based on Sabin Strains (sIPV) Given Intramuscularly in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: sIPV|BIOLOGICAL: cIPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Oral Semaglutide w/ Placebo- Treatment for Latino Adults w/T2 Diabetes Receiving Enhanced Lifestyle Care
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2|Glucose Metabolism Disorders (Including Diabetes Mellitus)
Interventions: DRUG: Semaglutide Pill|DIETARY_SUPPLEMENT: Fresh organic vegetables
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cetuximab and Cisplatin in the Treatment of "Triple Negative" (Estrogen Receptor [ER] Negative, Progesterone Receptor [PgR] Negative, and Human Epidermal Growth Factor Receptor 2 [HER2] Negative) Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasm
Interventions: DRUG: cetuximab, cisplatin|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Vesalio NeVa Stent Retriever Registry Study for Treatment of Large Vessel Occlusion Strokes
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DEVICE: NeVa Stent Retriever
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Pharmacokinetics of Prototype Modified-Release Formulations Of Apremilast in Healthy Men
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Apremilast Immediate Release|DRUG: Apremilast Modified Release 1|DRUG: Apremilast Modified Release 2|DRUG: Apremilast Modified Release 3|DRUG: Apremilast Modified Release 4|DRUG: Apremilast Modified Release 5|DRUG: Apremilast Modified Release 6|DRUG: Apremilast Modified Release 8|DRUG: Apremilast Modified Release 9|DRUG: Apremilast Modified Release 11|DRUG: Apremilast Modified Release 12|DRUG: Apremilast Modified Release 13|DRUG: Apremilast Modified Release 14
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Platelet-Rich Plasma in the Therapy of Temporomandibular Disorders
Status: COMPLETED
Conditions: PRP|Temporomandibular Disorder|Myalgia|Bruxism
Interventions: BIOLOGICAL: Platelet-Rich Plasma intramuscular injections|BIOLOGICAL: Placebo Comparator: 0,9% NaCl intramuscular injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Pivotal Study of N-Acetyl-L-Leucine on Niemann-Pick Disease Type C
Status: ACTIVE_NOT_RECRUITING
Conditions: Niemann-Pick Disease, Type C
Interventions: DRUG: N-Acetyl-L-Leucine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations
Status: COMPLETED
Conditions: Cryptogenic Sensory Polyneuropathy
Interventions: DRUG: Nortriptyline|DRUG: Duloxetine|DRUG: Pregabalin|DRUG: Mexiletine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Ruxolitinib Versus Anagrelide in Subjects With Essential Thrombocythemia Who Are Resistant to or Intolerant of Hydroxyurea (RESET-272)
Status: TERMINATED
Conditions: MPN (Myeloproliferative Neoplasms)
Interventions: DRUG: Ruxolitinib|DRUG: Anagrelide|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacies of Entecavir Add on HBeAg Positive Patients With HBV DNA Positive During Peginterferon Alpha 2a Treatment
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II, Prospective Study of MRI in the Reclassification of Men Considering Active Surveillance in Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DEVICE: Multiparametric MRI|PROCEDURE: Prostate biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ASP1517 Pharmacokinetics Study in Anemia Patients on Hemodialysis
Status: COMPLETED
Conditions: Anemia|Hemodialysis|Renal Impairment
Interventions: DRUG: roxadustat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bigfoot Biomedical Clinical Research Center (CRC) Trial
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Bigfoot Biomedical Type 1 Diabetes Management System (T1DMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
Status: RECRUITING
Conditions: Inflammatory Bowel Disease|Crohn Disease
Interventions: DIAGNOSTIC_TEST: Coronal T1 weighted spin echo images|DIAGNOSTIC_TEST: Spin-lattice relaxation (T1)|DIAGNOSTIC_TEST: Magnetic resonance spectroscopy|DIAGNOSTIC_TEST: Blood Draw
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TAS 102 in Combination With Ramucirumab in Advanced, Refractory Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma
Status: COMPLETED
Conditions: Gastric Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma|Gastric Cancer
Interventions: DRUG: TAS 102|DRUG: Ramucirumab 10 MG/ML Intravenous Solution [CYRAMZA]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Controlled Trial Comparing the Performance of 22 Gauge Versus 25 Gauge EUS-FNA Needles (FNA-22G-25G)
Status: COMPLETED
Conditions: Mediastinal Tumours and Lymph Nodes|Celiac, Perigastric and Peri-pancreatic Lymph Nodes|Pancreatic Masses|Liver Masses|Adrenal Masses
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Effect of LY2189265 on Two Blood Pressure Drugs
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BIOLOGICAL: LY2189265|DRUG: Metoprolol|DRUG: Lisinopril|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Switching From DAPT to Dual Pathway Inhibition With Low-dose Rivaroxaban in Adjunct to Aspirin in Patients With Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Clopidogrel|DRUG: Prasugrel|DRUG: ticagrelor|DRUG: aspirin|DRUG: rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AT-301 Nasal Spray in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AT-301B|DRUG: AT-301A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Сlinical Trial of Efficacy and Safety of Prospekta in the Treatment of Post-COVID-19 Asthenia.
Status: COMPLETED
Conditions: Post-acute COVID-19 Syndrome
Interventions: DRUG: Prospekta|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 90Y-ibritumomab Tiuxetan Consolidation After 6th R-CHOP Chemotherapy in Patients With Bulky Diffuse Large B Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Large B-Cell, Diffuse
Interventions: DRUG: ibritumomab tiuxetan (Zevalin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Moderating Role of Baseline Oxytocin on Its Psychotherapy-facilitating Effects Among Patients With Eating Disorders
Status: NOT_YET_RECRUITING
Conditions: Eating Disorders
Interventions: DRUG: Oxytocin nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccination in Inflammatory Rheumatic Disease (VACCIMIL). The Impact of Antirheumatic Treatment on Antibody Response
Status: COMPLETED
Conditions: RA|SLE|Vasculitis|Scleroderma|Sjögrens|Syndrome
Interventions: BIOLOGICAL: 0,5 mg Prevenar i.m.|BIOLOGICAL: 0,5 mg seasonal influenza vaccine i.m.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Control Trial Comparing Transfascial Suture for Mesh Fixation to No Mesh Fixation
Status: COMPLETED
Conditions: Ventral Hernia|Incisional Hernia
Interventions: PROCEDURE: Mesh placement with Transfascial Sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Full Face Snorkel Masks (FFSMs)
Status: COMPLETED
Conditions: Snorkeling|Face Mask Squeeze|Underwater Physiology|Swimming Physiology
Interventions: OTHER: Full Face Snorkel Mask (FFSM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of Robot-Assisted Upper Extremity Rehabilitation in Children With Cerebral Palsy
Status: RECRUITING
Conditions: Cerebral Palsy|Upper Extremity Problem
Interventions: OTHER: Robot-assisted upper extremity rehabilitation|OTHER: Conventional rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Study to Assess the Effect of Plasma Exchange in Accelerating the Clearance of Natalizumab in Subjects With Multiple Sclerosis (MS)
Status: COMPLETED
Conditions: Relapsing Forms of Multiple Sclerosis
Interventions: PROCEDURE: Plasma exchange|DRUG: natalizumab treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Study Comparing Medium or High Dose Uva-1 Treatment 3x/Week Versus Fluocinonide 0.05% Cream in the Treatment of Morphea.
Status: COMPLETED
Conditions: Symmetric Limited Morphea
Interventions: OTHER: Medium Dose UVA-1|OTHER: High Dose UVA-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Retrobulbar Triamcinolone Acetonide Injection in the Treatment of NA-AION
Status: UNKNOWN
Conditions: Triamcinolone Acetonide|Optic Neuropathy, Ischemic
Interventions: DRUG: Triamcinolone Acetonide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arterial Stiffness, Blood Pressure and Cardiac Output Study
Status: COMPLETED
Conditions: Infrarenal Abdominal Aortic Aneurysm
Interventions: DIAGNOSTIC_TEST: Pulse wave analyses; central blood presaure parameters
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparing The Effectiveness And Safety Of 2 Doses Of An Experimental Drug, CP-690,550, To Methotrexate (MTX) In Patients With Rheumatoid Arthritis Who Have Not Previously Received MTX
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: CP-690,550|DRUG: CP-690,550|DRUG: Disease-modifying antirheumatic drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mobilization With Movement (MWM) on Knee Osteoarthritis (OA)
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Osteoarthritis
Interventions: OTHER: Movement with Mobilization (MWM)|OTHER: Sham Movement with Mobilization (Sham MWM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the PK and Pharmacodynamics of IPX203 in Subjects With Advanced Parkinson's Disease
Status: COMPLETED
Conditions: Advanced Parkinson's Disease
Interventions: DRUG: Sinemet|DRUG: IPX203
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Darvadstrocel in Adults With Crohn's Disease and Complex Perianal Fistula
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn's Disease|Complex Perianal Fistula
Interventions: BIOLOGICAL: Darvadstrocel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determining the Association of Microvascular Disease as Assessed by PET and Graft Injury by Donor Derived Cell Free DNA
Status: SUSPENDED
Conditions: Cardiac Allograft Vasculopathy|Endothelial Dysfunction|Microvascular Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: Blood draw to measure the levels of dd-cf DNA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Papillary Balloon Dilatation Vs.Sphincterotomy for Lithotripsy in Difficult Sphincterotomy or Distal CBD Tapering
Status: UNKNOWN
Conditions: Choledocholithiasis
Interventions: PROCEDURE: Endoscopic papillary balloon dilatation|PROCEDURE: Endoscopic sphincterotomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Umbilical Cord Blood Mononuclear Cells for Hypoxic Neurologic Injury in Infants With Congenital Diaphragmatic Hernia (CDH)
Status: TERMINATED
Conditions: Congenital Diaphragmatic Hernia
Interventions: BIOLOGICAL: Autologous umbilical cord blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Iso-Osmolar and Ipo-Osmolar Contrast Agents in Patients With Acute Myocardial Infarction (AMI) Undergoing Primary Percutaneous Coronary Intervention (PCI)
Status: COMPLETED
Conditions: Contrast Induced Nephropathy|Acute Myocardial Infarction
Interventions: DRUG: Iodixanol|DRUG: Iopromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Emergency Obstetric and Neonatal Care: The EmONC Trial
Status: COMPLETED
Conditions: Maternal Morbidity and Mortality|Stillbirth and Neonatal Mortality
Interventions: BEHAVIORAL: Community Mobilization, HBLSS and facility improvement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Inhaled Fluticasone Effects on Upper Airway Patency in Obstructive Lung Disease
Status: TERMINATED
Conditions: Asthma|Chronic Obstructive Pulmonary Disease|Obstructive Sleep Apnea
Interventions: DRUG: Inhaled Fluticasone Propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Post Market Study Of Single Incision Sling Versus Transobturator Sling for Stress Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: Solyx Single Incision Sling System|DEVICE: Obtryx II Sling System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibrutinib, Fludarabine, and Pembrolizumab in High-Risk or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: B-Cell Chronic Lymphocytic Leukemia|B-Lymphocytic Leukemia, Chronic|Chronic Lymphocytic Leukemia|Leukemia, Chronic Lymphatic|Leukemia, Chronic Lymphocytic, B-Cell|Leukemia, Lymphocytic, Chronic|Leukemia, Lymphocytic, Chronic, B-Cell|Lymphocytic Leukemia, Chronic, B Cell|Lymphocytic Leukemia, Chronic, B-Cell
Interventions: DRUG: Ibrutinib|DRUG: Fludarabine|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SGLT2 Inhibitors Between Reno Protective Effects and Impact on Bone and Mineral Disease Among Lupus Nephritis Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: SGLT2 INHIBITORS|Lupus Nephritis|BMD
Interventions: DRUG: Dapagliflozin tablet|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Involvement of Pollutants in Atopic Dermatitis and Psoriasis
Status: NOT_YET_RECRUITING
Conditions: Psoriasis|Atopic Dermatitis
Interventions: OTHER: blood sampling|OTHER: urine sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Open-Label, Multi-Center, Phase IIa Trial of PRX302 Treatment of Patients With Locally Recurrent Prostate Cancer After Primary Radiation Therapy
Status: COMPLETED
Conditions: Locally Recurrent Prostate Cancer
Interventions: DRUG: PRX302
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Techniques for Perioperative Analgesia for Live Liver Donors; A Pilot Study
Status: UNKNOWN
Conditions: Anesthesia
Interventions: DRUG: Fentanyl infusion|PROCEDURE: Ultrasound guided TAP block|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Autologous Stem Cell Transplant With Pomalidomide (CC-4047®) Maintenance Versus Continuous Clarithromycin/ Pomalidomide / Dexamethasone Salvage Therapy in Relapsed or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Pomalidomide|PROCEDURE: stem cell|DRUG: Dexamethasone|DRUG: Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Effects of BCG in Adults With MCI and Mild-to-Moderate AD
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild Cognitive Impairment|Mild Dementia|Moderate Dementia|Alzheimer Disease
Interventions: BIOLOGICAL: Biological/Vaccine: Bacillus Calmette-Guerin (BCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: HoloStream Study - Video Capture Device Usage
Status: UNKNOWN
Conditions: Nephrostomy; Complications|Fistula|Central Venous Catheter Thrombosis
Interventions: OTHER: VSI streamer and Microsoft Hololens 2 classed as a Class III device by Health Canada.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Find a Safe and Effective Dose of SKI-G-801 in the Treatment of Patients With Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: SKI-G-801
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Market Feasibility Study of the Tenon Medical CATAMARAN™ SI Joint Fusion System
Status: RECRUITING
Conditions: Sacroiliac Joint Disruption|Degenerative Sacroiliitis
Interventions: DEVICE: CATAMARAN SI Joint Fusion System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for Pulmonary Diseases
Status: RECRUITING
Conditions: Pulmonary Disease|Asthma|Chronic Obstructive Pulmonary Disease
Interventions: BIOLOGICAL: AlloRx
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tailoring Treatment Targets for Early Autism Intervention in Africa
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Early Start Denver Model (ESDM)|BEHAVIORAL: Telehealth coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Breath Training Exercise for the Reduction of Chronic Dyspnea
Status: COMPLETED
Conditions: Chronic Pulmonary Disorder
Interventions: OTHER: breathing techniques|BEHAVIORAL: Self-Administered Baseline and Transition Dyspnea Indexes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CPX-351 Versus Immediate Stem Cell Transplantation for the Treatment of High-Grade Myeloid Cancers With Measurable Residual Disease
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome With Excess Blasts-2|Myeloid Neoplasm
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Liposome-encapsulated Daunorubicin-Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Cytokine-induced Killer Cells for Advanced Malignant Gliomas
Status: NOT_YET_RECRUITING
Conditions: Cytokine-Induced Killer Cells|Advanced Milignant Gliomas
Interventions: DRUG: Temozolomide|BIOLOGICAL: CIK
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Periodontal Phenotype and Laterally Positioned Flap in Isolated Gingival Recession
Status: UNKNOWN
Conditions: Gingival Recession
Interventions: PROCEDURE: Laterally positioned flap in thick periodontal phenotype.|PROCEDURE: Laterally positioned flap in thin periodontal phenotype.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: interACTION: A Portable Joint Function Monitoring and Training System to Supplement Home Exercise Programs Following Anterior Cruciate Ligament Reconstruction
Status: WITHDRAWN
Conditions: Anterior Cruciate Ligament Reconstruction
Interventions: DEVICE: interACTION|OTHER: Standard of Care Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fasting Study of Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg and Lopressor HCT® Tablets 100/50 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg|DRUG: Lopressor HCT® Tablets 100/50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Angiotensin (1-7) Treatment to Improve Cognitive Functioning in Heart Failure Patients
Status: SUSPENDED
Conditions: Chronic Heart Failure|Cognitive Impairment
Interventions: DRUG: Angiotensin-(1-7)|BEHAVIORAL: Memory Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Digitoxin to Treat Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: digitoxin|DRUG: digitoxin|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Efficacy of RLS103 in Subjects With Acute Anxiety Within Social Anxiety Disorder (SAD)
Status: WITHDRAWN
Conditions: Social Anxiety Disorder
Interventions: DRUG: Low dose RLS103|DRUG: High dose RLS103|DRUG: placebo inhaled dry powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Benefit of Two Immunosuppressive Strategies on Renal Function
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Everolimus|DRUG: Tacrolimus|DRUG: Mycophenolate sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRI Measurement of the Effects of Deep Neuromuscular Blockade on the Abdominal Working Space During Laparoscopy
Status: UNKNOWN
Conditions: Neuromuscular Block|Surgery
Interventions: PROCEDURE: No Rocuronium|DRUG: Rocuronium (moderate NMB)|DRUG: Rocuronium (deep NMB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurostimulation Applied to Fibromyalgia
Status: UNKNOWN
Conditions: Fibromyalgia
Interventions: DEVICE: Active tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of TH-302 in Combination With Doxorubicin Versus Doxorubicin Alone to Treat Patients With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: TH-302 in Combination with Doxorubicin|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 68Ga-THP-PSMA PET/CT Imaging in High Risk Primary Prostate Cancer or Biochemical Recurrence of Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Gallium-68 THP-PSMA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Effectiveness of TaurusTrio™ Heart Valve System in Patients With Severe Aortic Regurgitation (AR)
Status: RECRUITING
Conditions: Aortic Regurgitation
Interventions: DEVICE: TaurusTrio™ Heart Valve System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of PRV211 in Subjects With Oral Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Oral Squamous Cell Carcinoma
Interventions: DRUG: PRV211 (Intraoperative Cisplatin System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-op Treatment With Hyaluronic Acid Injections
Status: TERMINATED
Conditions: Meniscus Tear|Chondropathy/Degenerative Joint Disease (DJD)
Interventions: DEVICE: Euflexxa|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Time to Heal (Wound, Healing, Dialogue, Nutrition)
Status: RECRUITING
Conditions: Leg Ulcer|Venous Leg Ulcer|Arterial Leg Ulcer|Foot Ulcer, Diabetic|Amputation Stump
Interventions: OTHER: SNAK intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Heated Intraperitoneal Chemotherapy in Primary Ovarian Cancer Patients
Status: RECRUITING
Conditions: Ovarian Cancer|Epithelial Ovarian Cancer|Fallopian Tube Cancer
Interventions: PROCEDURE: HIPEC|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protein Phosphatase 2A Inhibitor, in Recurrent Glioblastoma
Status: COMPLETED
Conditions: Astrocytoma, Grades II, III and IV|Glioblastoma Multiforme|Giant Cell Glioblastoma|Glioma|Oligodendrogliomas
Interventions: DRUG: LB-100
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Quadratus Lumborum Block (QLB) for Pain Relief After Caesarean Section
Status: COMPLETED
Conditions: Quadratus Lumborum Block
Interventions: PROCEDURE: Quadratus lumborum block|PROCEDURE: Sham QLB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan and Gemcitabine in Treating Patients With Refractory Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: gemcitabine hydrochloride|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Micafungin Versus AmBisome in Invasive Candidiasis and Candidemia
Status: COMPLETED
Conditions: Candidiasis
Interventions: DRUG: Micafungin|DRUG: Liposomal Amphotericin B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Comparison of HYAJOINT Plus and Hyalgan Hyaluronan Supplement for Knee Osteoarthritis Pain
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: HYAJOINT Plus|DEVICE: Hyalgan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Alirocumab (SAR236553/REGN727) Versus Ezetimibe on Top of Statin in High Cardiovascular Risk Patients With Hypercholesterolemia (ODYSSEY COMBO II)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Alirocumab|DRUG: Placebo (for alirocumab)|DRUG: Ezetimibe|DRUG: Placebo (for ezetimibe)|DRUG: Lipid Modifying Therapy (LMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Capecitabine and Interferon-Alpha in Metastatic Renal Cell Carcinoma Patients With Failure on Interleukin-2 Based Regimens
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: capecitabine, interferon-alpha
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Parecoxib Combined With Paracetamol in Mastectomy
Status: RECRUITING
Conditions: Post Operative Pain
Interventions: DRUG: Parecoxib + paracetamol|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Whole Brain Radiation Therapy Alone vs. Radiosurgery for SCLC Patients With 1-10 Brain Metastases
Status: COMPLETED
Conditions: SCLC|Brain Metastases
Interventions: RADIATION: SRS|RADIATION: WBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of OPC-41061 in Patients With Hepatic Edema - Investigation of the Safety of Treatment at 7.5 mg Beyond 7 Days and of the Effect of Dose Escalation to 15 mg
Status: COMPLETED
Conditions: Cirrhosis
Interventions: DRUG: OPC-41061
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Antinib Hydrochloride Combined With Sindilumab in Advanced NSCLC Patients
Status: UNKNOWN
Conditions: NSCLC
Interventions: DRUG: Amlotinib+Sindili
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Epigallocatechin-3-Gallate Solution as a Root Canal Irrigant on Post-Operative Pain Intensity and Bacterial Load Reduction in Necrotic Tooth
Status: NOT_YET_RECRUITING
Conditions: Necrotic Pulp
Interventions: OTHER: Epigallocatechin-3-gallate|OTHER: sodium hypochlorite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Parallel Group Study, Comparing the Efficacy, Safety and Tolerability of the Fixed Dose Combination (FDC) of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol (FF/UMEC/VI) With the FDC of FF/VI in Subjects With Inadequately Controlled Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: FF/UMEC/VI (100/31.25/25) mcg|DRUG: FF/UMEC/VI (100/62.5/25) mcg|DRUG: FF/UMEC/VI (200/31.25/25) mcg|DRUG: FF/UMEC/VI (200/62.5/25) mcg|DRUG: FF/VI (100/25) mcg|DRUG: FF/VI (200/25) mcg|DRUG: Fluticasone/salmeterol (FSC)|DRUG: Albuterol/salbutamol|DEVICE: ELLIPTA DPI|DEVICE: DISKUS DPI|DEVICE: METERED-DOSE INHALER (MDI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigational Drug in Combination With Two Chemotherapy Drugs in Women With Locally Recurrent or Metastatic Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer|Metastatic Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: Ixabepilone|DRUG: Capecitabine|DRUG: Motesanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fascia Iliaca Compartment Block and PENG Block for Hip Arthroplasty
Status: WITHDRAWN
Conditions: Hip Fractures|Hip Injuries|Hip Arthropathy
Interventions: OTHER: Postoperative analgesia management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Algorithmically Enhanced Personalized Music-based Intervention on Stress Reduction in Cancer Patients
Status: RECRUITING
Conditions: Cancer|Stress
Interventions: BEHAVIORAL: Rubato Life Music|BEHAVIORAL: Music of their desire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Evaluation of the Regenerative Capacity of Two Platelet Concentrates
Status: UNKNOWN
Conditions: Necrotic Pulp
Interventions: PROCEDURE: Injectable platelet-rich fibrin|PROCEDURE: Platelet-rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Compare Pharmacokinetics Of Dacomitinib (PF-00299804) Between Healthy Subjects And Subjects With Mild And Moderate Hepatic Impairment
Status: COMPLETED
Conditions: Healthy|Otherwise Healthy Volunteers With Mild or Moderate Hepatic Dysfunction
Interventions: DRUG: dacomitinib|DRUG: dacomitinib|DRUG: dacomitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Hydroxychloroquine vs Placebo to Prevent COVID-19 Infection in Patients Receiving Radiotherapy
Status: TERMINATED
Conditions: COVID-19|Cancer
Interventions: DRUG: Hydroxychloroquine|OTHER: Placebo|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Pyridoxamine Supplementation on Vascular Function and Insulin Sensitivity
Status: COMPLETED
Conditions: Abdominal Obesity Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Pyridoxamine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Safety, Mode of Action and Clinical Efficacy of GSK3050002 in Subjects With Psoriatic Arthritis
Status: WITHDRAWN
Conditions: Autoimmune Diseases
Interventions: DRUG: GSK3050002|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Handy Hygiene of Children: Understanding the Effect of Live Feedback on Handwashing Behavior
Status: COMPLETED
Conditions: Hand Hygiene|Handwashing
Interventions: OTHER: Live feedback during handwashing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Investigation of Ascending Concentrations of Glycopyrronium Bromide (GPB) in a Topical Formulation in Subjects With Axillary Hyperhidrosis
Status: COMPLETED
Conditions: Primary Axillary Hyperhidrosis
Interventions: DRUG: WO3979|DRUG: WO3970|DRUG: WO3992|DRUG: Placebo (WO3988)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Plant Concentrate Blend on Oxidative Stress in Healthy Humans
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: AOX blend|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I Study of Ixabepilone Plus Lapatinib With or Without Capecitabine in the Treatment of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer
Status: TERMINATED
Conditions: Locally Advanced or Metastatic Breast Cancer
Interventions: DRUG: Ixabepilone, 32 mg/m^2 + Lapatinib, 1000 mg|DRUG: Ixabepilone, 32 mg/m^2 + Lapatinib, 1250 mg|DRUG: Ixabepilone, 40 mg/m^2 + Lapatinib, 1250 mg|DRUG: Ixabepilone + Lapatinib + Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glypican 3-specific Chimeric Antigen Receptor Expressing T Cells for Hepatocellular Carcinoma (GLYCAR)
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: GENETIC: GLYCAR T cells|DRUG: Cytoxan|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study the Effect of Avanafil on the Pharmacodynamics and Pharmacokinetics of Warfarin in Healthy Male Subjects
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: 200 mg Avanafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Highly Purified Anhydrous (HPA) Lanolin Versus Extra-Virgin Coconut Oil in Preventing Subacute Lactation Mastitis
Status: ENROLLING_BY_INVITATION
Conditions: Lactation Mastitis|Breast Feeding|Staphylococcus Aureus Infection
Interventions: DIETARY_SUPPLEMENT: Extra-Virgin Coconut Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eletriptan vs Sumatriptan: A Double-blind, Placebo-controlled, Multiple Migraine Attack Study
Status: COMPLETED
Conditions: Migraine With or Without Aura
Interventions: DRUG: Placebo|DRUG: Eletriptan 40 mg|DRUG: Eletriptan 80 mg|DRUG: Sumatriptan 50 mg|DRUG: Sumatriptan 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Bimatoprost and Latanoprost in Patients With Chronic Angle-Closure Glaucoma: A Randomized Cross-Over Study
Status: UNKNOWN
Conditions: Glaucoma, Angle-Closure
Interventions: DRUG: Latanoprost-Bimatoprost|DRUG: Bimatoporost-Latanoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NAVA vs PSV Ventilation During Weaning From Mechanical Ventilation in Children After Liver Transplantation
Status: UNKNOWN
Conditions: Pediatric Liver Transplantation|Weaning From Mechanical Ventilation
Interventions: PROCEDURE: Weaning from mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Plasmalogen on Obese Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Plasmalogen|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeting the IPA and Matching for the Non-Inherited Maternal Antigen for Haplo-Cord Transplantation
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematologic Malignancies
Interventions: DEVICE: CliniMACS® CD34 Reagent System|DRUG: Fludarabine|DRUG: Melphalan|DRUG: anti-thymocyte globulin (rabbit)|DRUG: Rituximab|RADIATION: Total Body Irradiation|DRUG: Mycophenolate Mofetil|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Character-Strengths Based Coaching For Work-Stress Reduction For Health Workers
Status: RECRUITING
Conditions: Work Related Stress|Burnout, Psychological|Mental Health Issue
Interventions: BEHAVIORAL: Character Strengths Based Coaching Support|BEHAVIORAL: Routine Supervision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Handheld Ultrasound Evaluation of the Inferior Vena Cava to Guide Heart Failure Treatment
Status: TERMINATED
Conditions: Heart Failure
Interventions: DEVICE: Handheld ultrasound|DEVICE: Sham ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rescue Stenting in the Severe Atherosclerotic Stenosis After the Failure of Intravenous Thrombolysis
Status: COMPLETED
Conditions: Ischemic Stroke, Acute|Stent Stenosis|Thrombosis
Interventions: PROCEDURE: Rescue stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of the Orelabrutinib in the Management of Refractory ITP
Status: UNKNOWN
Conditions: Immune Thrombocytopenia|Bruton's Tyrosine Kinase
Interventions: DRUG: Orelabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Allovectin-7® for Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer|Squamous Cell Carcinoma of the Oral Cavity or Oropharynx|Head and Neck Neoplasms|Carcinoma of the Head and Neck
Interventions: GENETIC: Allovectin-7®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclosporine (CSA) Level in Blood Samples Collected From Different Lines
Status: COMPLETED
Conditions: Hematopoietic Stem Cell Transplantation
Interventions: OTHER: Blood collection immediately after interrupting CSA infusion|OTHER: Blood collection five minutes after interrupting CSA infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Cognitive Behavior Therapy for Patients With Psychoses.
Status: COMPLETED
Conditions: Schizophrenia Spectrum and Other Psychotic Disorders
Interventions: BEHAVIORAL: Cognitive Behavior Therapy|BEHAVIORAL: Acceptance and Commitment Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Biosimilar Natalizumab PB006 in Comparison to Tysabri®
Status: COMPLETED
Conditions: Relapsing-Remitting Multiple Sclerosis (RRMS)
Interventions: BIOLOGICAL: Intravenous (IV) infusions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin Injection Prevent Paroxysmal Atrial Fibrillation
Status: UNKNOWN
Conditions: Paroxysmal Atrial Fibrillation
Interventions: PROCEDURE: endomyocardial BT injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contribution of Skin Color in Stabilization of Active Cases of Vitiligo by Narrow Band UVB
Status: UNKNOWN
Conditions: Vitiligo
Interventions: DRUG: Oral dexamethasone minipulse|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Maxx Orthopedics' PCK Revision TKA Study of Component Survivorship
Status: UNKNOWN
Conditions: Aseptic Loosening|Infection|Bone Loss|MCL - Medial Collateral Ligament Rupture of the Knee|Periprosthetic Fractures
Interventions: DEVICE: Freedom Knee PCK Components
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Stabilizing Reversal and Rhythmic Stabilization vs Pelvic Proprioceptive Neuromuscular Facilitation in Stroke Patients
Status: RECRUITING
Conditions: Stroke, Ischemic
Interventions: OTHER: Stabilizing Reversals and Rhythmic Stabilization|OTHER: Pelvic Proprioceptive Neuromuscular Facilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT