pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy of a Novel MAD in OSA
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive|Apnea, Obstructive|OSA|OSAH|Obstructive Sleep Apnea|Obstructive Sleep Apnea Syndrome
Interventions: DEVICE: Velo-Lingual Bite (BVL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dysregulation of Glutamine Activity in the Pathogenesis of Multiple Myeloma
Status: COMPLETED
Conditions: Monoclonal Gammopathy of Undetermined Significance|Plasma Cell Myeloma
Interventions: OTHER: 5-Carbon C 13-labeled Glutamine|PROCEDURE: Biospecimen Collection|PROCEDURE: Biospecimen Collection|OTHER: Uniformly-labeled [13C]glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Erector Spinae Plane Block Versus Serratus Plane Block for Breast Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Breast Cancer
Interventions: DRUG: Bupivacaine Hcl 0.25% Inj|DRUG: Bupivacaine HCl Inj 0.25%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LY3214996 and Cetuximab Alone or in Combination With Abemaciclib for the Treatment of Unresectable or Metastatic Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colon Adenocarcinoma|Metastatic Colorectal Carcinoma|Metastatic Rectal Adenocarcinoma|Recurrent Colorectal Carcinoma|Stage III Colon Cancer AJCC v8|Stage III Colorectal Cancer AJCC v8|Stage III Rectal Cancer AJCC v8|Stage IIIA Colon Cancer AJCC v8|Stage IIIA Colorectal Cancer AJCC v8|Stage IIIA Rectal Cancer AJCC v8|Stage IIIB Colon Cancer AJCC v8|Stage IIIB Colorectal Cancer AJCC v8|Stage IIIB Rectal Cancer AJCC v8|Stage IIIC Colon Cancer AJCC v8|Stage IIIC Colorectal Cancer AJCC v8|Stage IIIC Rectal Cancer AJCC v8|Stage IV Colon Cancer AJCC v8|Stage IV Colorectal Cancer AJCC v8|Stage IV Rectal Cancer AJCC v8|Stage IVA Colon Cancer AJCC v8|Stage IVA Colorectal Cancer AJCC v8|Stage IVA Rectal Cancer AJCC v8|Stage IVB Colon Cancer AJCC v8|Stage IVB Colorectal Cancer AJCC v8|Stage IVB Rectal Cancer AJCC v8|Stage IVC Colon Cancer AJCC v8|Stage IVC Colorectal Cancer AJCC v8|Stage IVC Rectal Cancer AJCC v8|Unresectable Colon Adenocarcinoma|Unresectable Colorectal Carcinoma|Unresectable Rectal Adenocarcinoma
Interventions: DRUG: Abemaciclib|BIOLOGICAL: Cetuximab|DRUG: ERK1/2 Inhibitor LY3214996
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Methods of Immunization for Intramuscular Injections
Status: COMPLETED
Conditions: Consequences of Immunization Method
Interventions: PROCEDURE: Procedure: Z-track|PROCEDURE: Procedure: Bunch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of N-Methyl-D-Aspartate (NMDA)-Receptor Antagonism on Hyperalgesia, Opioid Use, and Pain After Radical Prostatectomy
Status: UNKNOWN
Conditions: Hyperalgesia|Pain|Prostate Cancer
Interventions: DRUG: Amantadine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: ECT
Clinical trial: Clinical Trial for Patients With a Stage IV Childhood Renal Tumor, Comparing Upfront Vincristine, Actinomycin-D and Doxorubicin (Standard Arm) With Upfront Vincristine, Carboplatin and Etoposide (Experimental Arm)
Status: NOT_YET_RECRUITING
Conditions: Childhood Renal Tumor
Interventions: DRUG: treatment Vincristin|DRUG: treatment Actinomycin-D|DRUG: treatment Doxorubicin|DRUG: treatment Carboplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Assess The Safety, Tolerability, And Pharmacokinetics (PK) Of Multiple Doses Of PF-06865571 In Healthy, Including Overweight And Obese, Adult Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: PF-06865571|DRUG: PF-06865571|DRUG: PF-06865571|DRUG: PF-06865571|DRUG: PF-06865571|DRUG: PF-06865571|DRUG: PF-06865571|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Regulatory Post Marketing Surveillance (rPMS) Study of Rybelsus (Oral Semaglutide) to Evaluate Safety and Effectiveness in Patients With Type 2 Diabetes Mellitus in Routine Clinical Practice in Korea
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Recombinant Human C1 Esterase Inhibitor (Conestat Alfa) in the Prevention of Acute Ischemic Cerebral and Renal Events After Transcatheter Aortic Valve Implantation
Status: RECRUITING
Conditions: Acute Ischemic Stroke|Acute Renal Injury
Interventions: DRUG: Conestat alfa (Ruconest®)|DRUG: NaCl 0.9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Steviol Glycoside for Use in Restoring Muscle Glycogen by Increasing the Rate of Glycogen Re-synthesis in Muscles
Status: UNKNOWN
Conditions: Glycogen Depletion
Interventions: DIETARY_SUPPLEMENT: Carbohydrate steviol glycosides|DIETARY_SUPPLEMENT: Placebo Corn Starch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IRX-2 Regimen and Durvalumab, for Incurable H&N Squamous Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Squamous Cell Carcinoma|Squamous Cell Carcinoma of the Head and Neck|Metastatic Squamous Cell Carcinoma|Oral Cavity Squamous Cell Carcinoma|Oropharynx Squamous Cell Carcinoma|Paranasal Sinus Squamous Cell Carcinoma|Hypopharynx Squamous Cell Carcinoma|Larynx Squamous Cell Carcinoma
Interventions: DRUG: Durvalumab|DRUG: IRX-2 Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Controlled DTI Evaluations in High School Football and Female Soccer to Evaluate Efficacy of Jugular Compression Collar
Status: COMPLETED
Conditions: MTBI - Mild Traumatic Brain Injury|Concussion, Mild
Interventions: OTHER: Q collar
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Video-based Coaching (VBC) in Gynecologic Surgery
Status: UNKNOWN
Conditions: Education|Surgery|Gynecologic Cancer
Interventions: OTHER: Video-based coaching|OTHER: Standard surgical teaching (master-apprentice model - (MAM))
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Recto-colic Enemas of Butyrate on the Digestive Disorders of Very Low Birth Weight Preterms <1250 Grams
Status: TERMINATED
Conditions: Very Low Birth Weight Preterms
Interventions: DRUG: Butyrate enemas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study of Different Processes of SHR2554 Tablets in Healthy Adult Subjects
Status: UNKNOWN
Conditions: Lymphoma
Interventions: DRUG: New Process SHR2554 tablet、Former Process SHR2554 tablet|DRUG: Former Process SHR2554 tablet、New Process SHR2554 tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Oral Hyaluronic Acid on the Skin
Status: COMPLETED
Conditions: Healthy Japanese Subjects
Interventions: DIETARY_SUPPLEMENT: Hyaluronic acid 75 mg/capsule|DIETARY_SUPPLEMENT: Hyaluronic acid 50 mg/capsule|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SKY vs. HEP in PTSD
Status: TERMINATED
Conditions: PTSD
Interventions: OTHER: Sudarshan Kriya Yoga|OTHER: Health Enhancement Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peri-operative rATG-perfusion of Solid Transplants
Status: COMPLETED
Conditions: Organ Preservation Solutions
Interventions: BIOLOGICAL: organ perfusion with rabbit anti-thymocyte globulin (rATG)|OTHER: organ perfusion with saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GS-5885, GS-9451 With Peginterferon Alfa 2a (PEG) and Ribavirin in Treatment-Naïve Subjects With Chronic Genotype 1 Hep C Virus Infection and IL28B CC Genotype
Status: TERMINATED
Conditions: Chronic Hepatitis C
Interventions: DRUG: GS-5885|DRUG: GS-9451|DRUG: RBV|DRUG: PEG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Ciprofol-based and Propofol-based Total Intravenous Anesthesia on Postoperative Quality of Recovery
Status: RECRUITING
Conditions: Anesthetics, Intravenous|Postoperative Complications|Hypnotics and Sedatives|Postoperative Recovery
Interventions: DRUG: Ciprofol|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
Status: RECRUITING
Conditions: Insulin Resistance|Depression|Depressive Disorder|Mood Disorders|Mental Disorder in Adolescence|Hyperinsulinism|Glucose Metabolism Disorders|Metabolic Disease
Interventions: BEHAVIORAL: Cognitive-Behavioral Therapy followed by Exercise Training|BEHAVIORAL: Exercise Training followed by Cognitive-Behavioral Therapy|BEHAVIORAL: Cognitive-Behavioral Therapy Only|BEHAVIORAL: Exercise Training Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) and Substance Use: A Pilot Study
Status: RECRUITING
Conditions: Psychosis|Substance Use|Substance Use Disorders|Family|Cannabis|Marijuana|Alcohol|Schizophrenia|Schizoaffective Disorder|Bipolar Disorder|Mental Disorder
Interventions: BEHAVIORAL: CRAFT-EP|BEHAVIORAL: TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Assessment of Hypertonic Saline in Moderate to Severe Asthmatics
Status: COMPLETED
Conditions: Moderate to Severe Asthma
Interventions: DEVICE: 3% Hypertonic Saline|DEVICE: 7% Hypertonic Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety of HSK31679 in Chinese Patients With Non-Alcoholic Steatohepatitis (NASH) .
Status: RECRUITING
Conditions: Non-Alcoholic Steatohepatitis (NASH)
Interventions: DRUG: HSK31679 80mg|DRUG: HSK31679 160mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GammaTile and Stupp in Newly Diagnosed GBM
Status: RECRUITING
Conditions: Glioblastoma
Interventions: DEVICE: Surgical tumor resection, GammaTile radiation therapy implantation, Stupp protocol (EBRT and Temozolamide)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Epigallocatechin-3-gallate (EGCG) for Supportive and Symptomatic Management in Patients With Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Obstruction
Interventions: OTHER: EGCG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Fatty Acids That Affect the Immune System in Kidney Transplant Patients
Status: COMPLETED
Conditions: Kidney Diseases
Interventions: DIETARY_SUPPLEMENT: Canola oil|DIETARY_SUPPLEMENT: Arginine|DIETARY_SUPPLEMENT: Fish oil emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lower Dose Decitabine Based Therapy in Patients With Refractory and/or Chemotherapy Resistant Solid Tumors or B Cell Lymphomas
Status: UNKNOWN
Conditions: Solid Tumors|B Cell Lymphoma
Interventions: DRUG: Decitabine|BIOLOGICAL: cytokine-induced killer cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IGF-I Stimulation of Collagen Synthesis in Ehlers-Danlos Patients
Status: COMPLETED
Conditions: Ehlers-Danlos Syndrome, Classic
Interventions: DRUG: mecasermin|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of TENS for the Recovery of Oral Function After Orthognathic Surgery
Status: COMPLETED
Conditions: Orthognathic Surgery|Physiology|Transcutaneous Electric Nerve Stimulation
Interventions: DEVICE: transcutaneous electrical nerve stimulation (TENS):Enraf Nonius® S82 model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy and Tolerability of T1210 and Olopatadine Hydrochloride 0.1% in the Treatment of Seasonal Allergic Conjunctivitis
Status: COMPLETED
Conditions: Seasonal Allergic Conjunctivitis
Interventions: DRUG: T1210|DRUG: Olopatadine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PRAGMA (Prostate Radio Ablation Guided by Magnetic Resonance Imaging Acquisition) in Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Metastatic Prostate Cancer
Interventions: RADIATION: MR-Guided Prostate SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mitralign Percutaneous Annuloplasty System for Chronic Functional Mitral Valve Regurgitation
Status: UNKNOWN
Conditions: Mitral Valve Regurgitation
Interventions: DEVICE: percutaneous annuloplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aura Adolescent PK Study GSK2829332
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: GSK573719|DRUG: GSK573719matched-placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL
Status: ACTIVE_NOT_RECRUITING
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: Brentuximab vedotin|DRUG: Rituximab|DRUG: Lenalidomide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: HELP Therapy for Dry AMD
Status: COMPLETED
Conditions: Non-exudative (Dry) Age-related Macular Degeneration (AMD)
Interventions: DEVICE: H.E.L.P. therapy (H.E.L.P. Plasmat Futura System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Digestive Tolerance of Orange Juice With Fibers
Status: UNKNOWN
Conditions: Digestive Alteration [PE]
Interventions: DIETARY_SUPPLEMENT: Fiber|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: STEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight Loss
Status: NOT_YET_RECRUITING
Conditions: Obesity
Interventions: DRUG: Semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Metformin and Rosiglitazone Over no Diabetic With Metabolic Syndrome Patients.
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: DRUG: Metformin group|DRUG: Rosiglitazone group|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vital Pulp Therapy (VPT) Using Calcium Enriched Mixture (CEM) to Treat Irreversible Pulpitis
Status: COMPLETED
Conditions: Irreversible Pulpitis
Interventions: PROCEDURE: Indirect pulp capping (IPC)|PROCEDURE: Direct pulp capping (DPC)|PROCEDURE: Miniature pulpotomy (MP)|PROCEDURE: Full pulpotomy (FP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: HEALEY ALS Platform Trial - Master Protocol
Status: ACTIVE_NOT_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Zilucoplan|DRUG: Verdiperstat|DRUG: CNM-Au8|DRUG: Pridopidine|DRUG: SLS-005 Trehalose|DRUG: ABBV-CLS-7262|DRUG: DNL343
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect Of Ophiochepalus Striatus Extract On Serum IGF-1 And IL-6 Levels In Elderly Patients With Sarcopenia
Status: COMPLETED
Conditions: Sarcopenia|Geriatric|Muscle Mass|Muscle Strength|Physical Performance
Interventions: DRUG: Ophiochepalus striatus extract|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pulsed Shortwave Therapy for Postoperative Analgesia
Status: ENROLLING_BY_INVITATION
Conditions: Postoperative Pain, Acute
Interventions: DEVICE: Active Pulsed Shortwave Treatment|DEVICE: Sham Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antiviral Efficacy and Acceptability of Mouth Rinses for Inactivation of COVID-19
Status: TERMINATED
Conditions: COVID19|Coronavirus Infection|SARS CoV-2 Infection
Interventions: OTHER: Water|OTHER: Peroxyl|DRUG: Periogard|OTHER: Colgate Total Zero
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral Support Before Anesthesia
Status: COMPLETED
Conditions: Nervousness|Life Experiences
Interventions: BEHAVIORAL: Only support from an anaesthetic nurse on the surgery ward|BEHAVIORAL: Support: a theatre nurse + an anaesthetic nurse|BEHAVIORAL: Support: a nurse from the ward + an anaesthetic nurse|BEHAVIORAL: Optional relative supports
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: WeCareAdvisor: A Web-Based Tool to Improve Quality of Life for Military Veterans With Dementia and Their Caregivers
Status: COMPLETED
Conditions: Dementia|Caregiver|Memory Disorders|Alzheimer Disease|Behavioral Symptoms
Interventions: BEHAVIORAL: WeCareAdvisor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder|Post Traumatic Stress Disorder|Generalized Anxiety Disorder|Social Anxiety Disorder|Panic Disorder
Interventions: BEHAVIORAL: Exposure-Based Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Open Label Study Using Triheptanoin in Patients With Glucose Type 1 Transporter Deficiency GLUT1-DS
Status: COMPLETED
Conditions: Glut1 Deficiency Syndrome
Interventions: DRUG: GLUT1 DS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib (AMG 510) in Subjects With Solid Tumors With a Specific KRAS Mutation (CodeBreaK 100)
Status: ACTIVE_NOT_RECRUITING
Conditions: KRAS p.G12C Mutant Advanced Solid Tumors
Interventions: DRUG: sotorasib|DRUG: Anti PD-1/L1|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alpha-synuclein Rt-quic and Neurologic Symptoms in Persons With idiOpathic anosMiA
Status: RECRUITING
Conditions: Idiopathic Anosmia|Idiopathic Hyposmia|Idiopathic Olfactory Dysfunction
Interventions: DIAGNOSTIC_TEST: RT-QuiC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Topical Cyclosporine and Disease Progression
Status: COMPLETED
Conditions: Disease Progression|Disease Severity|Staining|Schirmers|OSDI
Interventions: DRUG: Restasis|DRUG: Endura
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Measuring Various Variables in Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea-hypopnea Syndrome
Interventions: DIAGNOSTIC_TEST: taking a blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pediatric Intubation During Emergency Conditions
Status: COMPLETED
Conditions: Endotracheal Intubation|Pediatric|Cardiac Arrest|Injuries
Interventions: DEVICE: Macintosh laryngoscope|DEVICE: Miller laryngoscope|DEVICE: McGrath MAC EMS|DEVICE: GlideScope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Subarachnoid Anesthesia With Low Dose of Pethidine and Combination of Ropivacaine With Fentanyl for Urologic Surgical Operations.
Status: COMPLETED
Conditions: Low Dose of Pethidine for Subarachnoid Anesthesia
Interventions: DRUG: Pethidine hydrochloride|DRUG: Ropivacaine HCl Inj 7.5 MG/ML|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Clinical Study of Induction Therapy Options Based on Molecular Subtyping and MRD in Children and Adolescents With AML
Status: RECRUITING
Conditions: AML, Childhood|Acute Myeloid Leukemia
Interventions: DRUG: Homoharringtonine|DRUG: Cytarabine|DRUG: Etoposide|DRUG: Venetoclax|DRUG: Mitoxantrone hydrochloride liposome|DRUG: Recombinant Human Granulocyte Colony-Stimulating Factor|DRUG: Idarubicin Hydrochloride|DRUG: Sorafenib|DRUG: Gilteritinib|DRUG: Avapritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Side Effect Prevention Training (SEPT) for Nocebo Effects in Breast Cancer Patients
Status: UNKNOWN
Conditions: Female Breast Cancer
Interventions: BEHAVIORAL: Side effect prevention training (SEPT)|BEHAVIORAL: Attention Control group (ACG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective, Open Label, Multicenter Trial for Evaluating the Efficacy of Treating and Managing Wounds in Elderly Population in Specialized Nursing Facilities Using RD1
Status: COMPLETED
Conditions: Diabetic Foot Ulcer|Pressure Ulcer|Venous Leg Ulcer|Trauma Injury|Skin Tear|Chronic Ulcer
Interventions: DEVICE: RD1 System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Asymptomatic Fluid Overload in Peritoneal Dialysis Patients
Status: WITHDRAWN
Conditions: Chronic Kidney Disease|Peritoneal Dialysis
Interventions: COMBINATION_PRODUCT: treatment arm|BEHAVIORAL: Control arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cross-neutralization Capacity of Immune Serum From Different Dosage of Sabin Inactivated Poliovirus Vaccine Immunization
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: Three doses of low-dosage investigational sIPV, vaccinated within one-month interval between doses|BIOLOGICAL: Three doses of medium-dosage investigational sIPV, vaccinated within one-month interval between doses|BIOLOGICAL: Three doses of high-dosage investigational sIPV, vaccinated within one-month interval between doses|BIOLOGICAL: Three doses of control wIPV, vaccinated within one-month interval between doses|BIOLOGICAL: Three doses of control sIPV, vaccinated within one-month interval between doses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of a Psychoeducational Intervention on Myositis Patients' Quality of Life and Well-Being
Status: COMPLETED
Conditions: Quality of Life|Myositis
Interventions: BEHAVIORAL: Psychoeducative|BEHAVIORAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Augmented Posterior Oblique Sling Activation on Lumbopelvic Recruitment Pattern in Lumbosacral Radiculopathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Lumbosacral Radiculopathy
Interventions: OTHER: augmented posterior oblique sling activation|OTHER: selected physical therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of iDECIDE: A Smartphone App for Insulin Dosing Accounting for Alcohol and Exercise
Status: WITHDRAWN
Conditions: Type 1 Diabetes
Interventions: DEVICE: iDECIDE|DEVICE: Insulin pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings
Status: ACTIVE_NOT_RECRUITING
Conditions: Opioid Dependence|Addiction|HIV/AIDS|Tuberculosis|Hepatitis
Interventions: DRUG: Buprenorphine Naloxone|DRUG: Methadone|DRUG: Isoniazid|DRUG: Rifapentine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: GLP-1 - Regulatory Mechanism of Postprandial Glycemia
Status: COMPLETED
Conditions: Healthy Subjects|Gastric Emptying
Interventions: DRUG: Saline|DRUG: Exendin(9-39)amide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 2 Pilot Study to Assess ASP7147 in Patients With Diarrhea Predominant Irritable Bowel Syndrome (IBS-D)
Status: COMPLETED
Conditions: Diarrhea Predominant Irritable Bowel Syndrome
Interventions: DRUG: ASP7147|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect on Glycemic Responses and Subjective Ratings of Satiety of a Snack With or Without Ingredients to Slow Carbohydrate Digestion
Status: COMPLETED
Conditions: Glycemic Response; Satiety
Interventions: OTHER: Nutrient cluster
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Evaluation of the Safety and Efficacy of a New Multifocal Contact Lens
Status: COMPLETED
Conditions: Myopia|Ametropia|Presbyopia|Refractive Error
Interventions: DEVICE: Nelfilcon A multifocal contact lens with comfort additive|DEVICE: Nelfilcon A multifocal contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Danggui Buxue Decoction in Preventing Neutropenia
Status: COMPLETED
Conditions: Grade 3/4 Neutropenia|Febrile Neutropenia
Interventions: DRUG: DBD|DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Idiopathic Pulmonary Fibrosis With Long Acting Octreotide
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: octreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerability of Device Based Therapies for Neurofibromatosis Type 1 Cutaneous Neurofibromas
Status: ACTIVE_NOT_RECRUITING
Conditions: Cutaneous Neurofibroma
Interventions: DRUG: Kybella|DEVICE: 1064nm laser|DEVICE: 755nm Alexandrite Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Treatment Strategies in IgG4-RD Patients With Re-elevation of Serum IgG4 Level During Maintenance Remission Period
Status: NOT_YET_RECRUITING
Conditions: Autoimmune Diseases
Interventions: DRUG: placebo|DRUG: mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Pharmacokinetics (PK) and Safety of M834 and Orencia ®, in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: M834|BIOLOGICAL: US-Sourced Orencia®|BIOLOGICAL: EU-Sourced Orencia®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase I Study of Indibulin in Combination With Erlotinib in Advanced Solid Tumors
Status: UNKNOWN
Conditions: Advanced Solid Tumors
Interventions: DRUG: indibulin|DRUG: erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Anorexia Nervosa on Peak Bone Mass
Status: COMPLETED
Conditions: Anorexia Nervosa
Interventions: DRUG: RhIGF-1 with transdermal 17-beta estradiol|DRUG: Placebo and transdermal 17-beta estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Single Dose Nevirapine (NVP) Combined With Combivir® for the Prevention of Mother to Child Transmission (pMTCT) - Treatment Options Preservation Study (TOPS)
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome
Interventions: DRUG: Nevirapine (NVP)|DRUG: Zidovudine (ZCV)|DRUG: 3TC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Chemotherapy and Radiation Therapy (RT) With or Without Vandetanib in Treating Patients With High-Risk Stage III or Stage IV Head and Neck Cancer
Status: TERMINATED
Conditions: Head and Neck Cancer
Interventions: DRUG: cisplatin|DRUG: vandetanib|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HVNI vs Noninvasive Ventilation for Acute Hypercapnic Respiratory Failure
Status: UNKNOWN
Conditions: Comparison Between HVNI vs Noninvasive Ventilation for Acute Hypercapnic Respiratory Failure
Interventions: DEVICE: HVNI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of Lyso-thermosensitive Liposomal Doxorubicin and MR-HIFU for Pediatric Refractory Solid Tumors
Status: TERMINATED
Conditions: Pediatric Cancer|Solid Tumors|Rhabdomyosarcoma|Ewing Sarcoma|Soft Tissue Sarcomas|Osteosarcoma|Neuroblastoma|Wilms Tumor|Hepatic Tumor|Germ Cell Tumors
Interventions: DEVICE: Magnetic resonance high intensity focused ultrasound|DRUG: Lyso-thermosensitive liposomal doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antibiotic Treatment Trial for the PANDAS/PANS Phenotype
Status: COMPLETED
Conditions: PANS|PANDAS|Obsessive Compulsive Disorder (OCD)
Interventions: DRUG: Azithromycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Comparison of Three Soft Daily Disposable Contact Lenses
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: somofilcon A|DEVICE: nelfilcon A II 2|DEVICE: omafilcon A ll 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: V-Y Flap Versus Occlusive Dressing in Treating Fingertip Injuries With Exposed Bone
Status: COMPLETED
Conditions: Injury Arm
Interventions: PROCEDURE: Flaps Coverage|PROCEDURE: Occlusive Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TRANSLATE: Transgender and Gender Nonconforming Individuals' Access to Healthcare
Status: COMPLETED
Conditions: Gender Identity
Interventions: BEHAVIORAL: TGNC Directed Advocacy Meetings|BEHAVIORAL: Facilitated Dialogues between TGNC Cohort and Healthcare Participants
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase Ib, Open-label, Multi-center Dose-finding Study of Oral Panobinostat (LBH589) in Combination With Ara-C and Mitoxantrone as Salvage Therapy for Refractory or Relapsed Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: panobinostat/LBH589B
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Injectable IMM0306 in Combination With Lenalidomide
Status: NOT_YET_RECRUITING
Conditions: B-cell Non-Hodgkin's Lymphoma
Interventions: DRUG: IMM0306|DRUG: Lenalidomide capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic Chocolate Study in Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis|Healthy Nutrition
Interventions: DIETARY_SUPPLEMENT: Bouchard Belgian Dark Chocolate Probiotic Napolitains, containing bifidobacterium longum
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Novel Metabolites of Beta-Carotene and Lycopene
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Base diet + high beta-carotene tomato juice|OTHER: Base diet + high lycopene tomato juice|OTHER: Base diet + placebo beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Blinatumomab Maintenance Following Allogeneic Hematopoietic Cell Transplantation for Patients With Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Blinatumomab|PROCEDURE: Hematopoietic Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of TCD-10023 (Ultimaster) Drug-eluting Stent in STEMI Patients - MASTER Study
Status: COMPLETED
Conditions: Acute ST Segment Elevation Myocardial Infarction
Interventions: DEVICE: PCI in patients with ST-elevation myocardial infarction|DEVICE: PCI in patients with ST-elevation myocardial infarction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Simulation With Nursing Students in the Care of Patients With Sepsis
Status: UNKNOWN
Conditions: Learning Process in Nursing Graduation|Stress
Interventions: OTHER: High-Fidelity Simulation|OTHER: Low-Fidelity Simulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinical Performance of Two Daily Disposable Soft Contact Lenses
Status: COMPLETED
Conditions: Refractive Errors
Interventions: DEVICE: Verofilcon A contact lenses|DEVICE: Nesofilcon A contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Suicidal Behavior Through the VIGILANS Protocol: the Restoration of Social Connection Hypothesis
Status: UNKNOWN
Conditions: Suicidal Behaviour Disorder
Interventions: BEHAVIORAL: The virtual version of the Social stress task : V-TSST
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Find Out if the New Ebola Vaccine is Safe and Stimulates Immunity That Might Protect Adults in Kilifi, Kenya.
Status: UNKNOWN
Conditions: Ebola Virus Disease
Interventions: BIOLOGICAL: VSV-ZEBOV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Abemaciclib in Combination With Androgen Deprivation Therapy for Locally Advanced Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Abemaciclib 150 MG by mouth twice daily|DRUG: Androgen deprivation therapy (ADT)|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of FV-100 Versus Valacyclovir in Patients With Herpes Zoster
Status: COMPLETED
Conditions: Herpes Zoster|Shingles
Interventions: DRUG: valacyclovir|DRUG: FV-100|DRUG: FV-100|DRUG: Valacyclovir placebo|DRUG: FV-100 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of NicVAX in Smokers Who Want to Quit Smoking
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BIOLOGICAL: NicVAX conjugate vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vorapaxar and Lower Extremity Bypass Grafts
Status: WITHDRAWN
Conditions: Peripheral Artery Disease
Interventions: DRUG: Vorapaxar|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Erector Spinae Plane Block Versus Quadratus Lumborum Block for Postoperative Analgesia After Laparoscopic Resection of Colorectal Cancer.
Status: RECRUITING
Conditions: Pain, Postoperative
Interventions: PROCEDURE: Erector spinae plane block and transmuscular quadratus lumborum block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Double-blind, Randomized, Single Centre, Vehicle-controlled Study to Evaluate the Safety and Tolerability of a New Topical Formulation Containing 0,09% Imiquimod (Limtop) in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Imiquimod (topical use)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Diffusion MRI Methods to Minimize Postoperative Deficits in Pediatric Epilepsy Surgery
Status: RECRUITING
Conditions: Focal Epilepsy
Interventions: DIAGNOSTIC_TEST: Brain magnetic resonance imaging|BEHAVIORAL: Neuro-psychology testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial to Evaluate the Long-term Efficacy of Oral Aripiprazole in the Treatment of Pediatric Participants With Tourette's Disorder
Status: TERMINATED
Conditions: Tourette's Disorder (TD)
Interventions: DRUG: Aripiprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Safety and Tolerability of AKST1210 Column at 2 Blood Flow Rates in Subjects With ESRD on Hemodialysis
Status: COMPLETED
Conditions: End-Stage Renal Disease
Interventions: DEVICE: AKST1210 S-15 at 250 mL/min|DEVICE: AKST1210 S-15 at 450 mL/min|DEVICE: AKST1210 S-25 at 250 mL/min|DEVICE: AKST1210 S-25 at 450 mL/min|DEVICE: AKST1210 S-35 at 250 mL/min|DEVICE: AKST1210 S-35 at 450 mL/min
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Natriuretic Peptide (BNP) to Preserve Renal Function in Hospitalized Patients With Heart Failure
Status: COMPLETED
Conditions: Kidney Diseases|Congestive Heart Failure|Cardiomyopathy
Interventions: DRUG: Nesiritide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IL15 Dendritic Cell Vaccine for Patients With Resected Stage III (A, B or C) or Stage IV Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma Stage III|Malignant Melanoma Stage IV
Interventions: BIOLOGICAL: IL15-DC Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Study Assessing the Safety and Tolerability of Co-Formulated Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies (Casirivimab+Imdevimab) in Adult Volunteers
Status: COMPLETED
Conditions: Healthy|Chronic Stable Illness
Interventions: DRUG: Casirivimab+Imdevimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes of Buffered vs. Non-Buffered Lidocaine
Status: COMPLETED
Conditions: Blood Levels of Buffered vs Non-buffered Lidocaine|Anesthetics, Local
Interventions: DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics, and Pharmacodynamics of Oral Azacitidine in Subjects With Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia and Acute Myelogenous Leukemia
Status: COMPLETED
Conditions: Myelodysplastic Syndromes (MDS)|Chronic Myelomonocytic Leukemia (CMML)|Acute Myelogenous Leukemia (AML)
Interventions: DRUG: Subcutaneous (SC) Azacitidine|DRUG: Oral Azacitidine|DRUG: Oral Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Learning Curve of Manual Skills in Anesthesia Residents
Status: COMPLETED
Conditions: Intubation Skill|Laryngeal Mask Airway Insertion Skill|Spinal Anesthesia Skill|Epidural Anesthesia Skill|Radial Artery Cannulation Skill|Internal Jugular Vein Cannulation Skill
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reduction of Progesterone Elevation at Trigger in POR After Long Acting COS Compared With Daily COS: a Prospective Randomized Trial
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Corifollitropin alfa|DRUG: Follitropin Beta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Heart Rate Variability Changes During Cardiac Surgery And The Incidence Of Post-Operative Cardiac Arrhythmias
Status: WITHDRAWN
Conditions: Cardiac Arrhythmia
Interventions: DEVICE: Dataq Instruments DI-158
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CD30 CAR T Cells, Relapsed CD30 Expressing Lymphoma (RELY-30)
Status: RECRUITING
Conditions: Hodgkin's Lymphoma|Non-Hodgkin Lymphoma
Interventions: GENETIC: CAR T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Corticospinal Function After Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injury
Interventions: OTHER: Electrophysiology Assessment of Time Domain|OTHER: Electrophysiology Assessment of Location|OTHER: Training with some stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Different Feeding Method on Gastrointestinal Function of Critical Patients
Status: RECRUITING
Conditions: Gastrointestinal Dysfunction|Critical Illness|Nutrition Disorders
Interventions: PROCEDURE: Continuously feeding|PROCEDURE: 16-hours feeding|PROCEDURE: intermittent feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT