pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Behavioral Lifestyle Intervention Study (BLIS) in Patients With Type 2 Diabetes in UAE: A Randomized Controlled Trial in Real Life Setting
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Behvarioal lifestyle modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotics and Microbiota in Bariatric Surgery
Status: UNKNOWN
Conditions: NAFLD
Interventions: DIETARY_SUPPLEMENT: Bio-25 (Supherb)|DIETARY_SUPPLEMENT: Placebo (for Bio-25, Supherb)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between TOMOFIX and BodyCAD Fine Osteotomy
Status: NOT_YET_RECRUITING
Conditions: Osteotomy|Malalignment, Bone|Osteoarthritis, Knee
Interventions: PROCEDURE: High tibial osteotomy using TOMOFIX|PROCEDURE: High tibial osteotomy using BodyCAD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Omega-3 and Probiotic Dietary Supplements on Elevated High Sensitivity C-reactive Protein (Hs-CRP) as a Marker of Low-grade Inflammation
Status: COMPLETED
Conditions: Inflammation
Interventions: DIETARY_SUPPLEMENT: Probiotic, Omega-3, Vitamin D supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Olanzapine With Haloperidol for the Relief of Nausea and Vomiting in Patients With Advanced Cancer
Status: TERMINATED
Conditions: Nausea|Neoplasms
Interventions: DRUG: Olanzapine|DRUG: Haldol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Safety Study of Lodenafil Carbonate in Patients With Coronaropathy During Physical Effort
Status: WITHDRAWN
Conditions: Erectile Dysfunction|Coronaropathy
Interventions: DRUG: lodenafil carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Evaluation of Curative Effect on Treatment of Tumor Above Thalidomide Combined With Megestrol
Status: UNKNOWN
Conditions: Cancer, Therapy-Related
Interventions: DRUG: Chemotherapy drugs|DRUG: thalidomide and megestrol acetate|OTHER: optimal support treatment|DRUG: thalidomide and megestrol acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of IASTM in the Treatment of Adhesive Capsulitis
Status: COMPLETED
Conditions: Pain, Shoulder|Adhesion; Shoulder|Myofacial Pain
Interventions: OTHER: Standard Exercise|OTHER: Instrument Assisted Soft Tissue Mobilization (IASTM)|OTHER: Home Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lomecel-B Infusion Versus Placebo in Patients With Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: BIOLOGICAL: Longeveron Mesenchymal Stem Cells|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nurse-led Clinics Training Program on Mild Cognitive Impairment Patients
Status: RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: cognitive training in NLCs|BEHAVIORAL: cognitive training in home|BEHAVIORAL: cognitive training in tradition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Anti-CEACAM5 ADC M9140 in Advanced Solid Tumors (PROCEADE-CRC-01)
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: M9140|DRUG: M9140|DRUG: Bevacizumab|DRUG: Capecitabine|DRUG: 5-fluorouracil (5-FU)|DRUG: Folinic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Plasma Transfusion From Exercise-trained Donors in Patients With Early Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: ExPlas|DRUG: Octaplasma|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Compare the Clinical Efficacy of Prototype Toothpastes.
Status: COMPLETED
Conditions: Gingival Diseases
Interventions: DRUG: Fluoride|DRUG: Triclosan and fluoride|DRUG: Herbal Ingredient and fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Q-switched Nd:YAG Laser and Platelet Rich Plasma Versus Q- Switched Nd:YAG Laser Alone in Melasma
Status: UNKNOWN
Conditions: Hyperpigmentation|Melasma|PRP|Lasers
Interventions: OTHER: Q-switched nd:YAG laser toning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of CNV2197944 Versus Placebo in Patients With Post-herpetic Neuralgia
Status: COMPLETED
Conditions: Post-herpetic Neuralgia
Interventions: DRUG: CNV2197944|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Vitamin D Status in Children With Wheeze / Asthma (OPTIVIT)
Status: COMPLETED
Conditions: Asthmatic Crisis|Wheezing
Interventions: DIETARY_SUPPLEMENT: Fultium-D3 drops (Internis)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Dexmedetomidine on Bispectral Index and Propofol Requirements During Different Menstrual Cycle
Status: COMPLETED
Conditions: Abnormal Menstrual Cycle
Interventions: DRUG: dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: End Nicotine Dependence Clinic
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Group Counseling|BEHAVIORAL: Individual Counseling|BEHAVIORAL: Phone Counseling|BEHAVIORAL: Video Counseling|BEHAVIORAL: Texting support|DRUG: Nicotine Replacement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia
Status: UNKNOWN
Conditions: Trigeminal Neuralgia
Interventions: DEVICE: PainShield SAW Patch Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Impairment and Fatigue After Mild to Moderate COVID-19
Status: RECRUITING
Conditions: Post COVID-19 Condition|Cognitive Impairment|Fatigue, Mental
Interventions: DIAGNOSTIC_TEST: Neuropsychological investigation|DIAGNOSTIC_TEST: Optometric investigation|DIAGNOSTIC_TEST: Magnetic Resonance Imaging|DIAGNOSTIC_TEST: Immunological biomarkers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Berry Nectars Sweetened With Inverted Sugar on Post-meal Blood Sugar
Status: COMPLETED
Conditions: Hyperglycemia, Postprandial
Interventions: DIETARY_SUPPLEMENT: Blackcurrant Nectar|DIETARY_SUPPLEMENT: Lingonberry Nectar|DIETARY_SUPPLEMENT: Reference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multicenter Exploratory Study of Accelerometry in Dilated Cardiomyopathy
Status: WITHDRAWN
Conditions: Dilated Cardiomyopathy
Interventions: DEVICE: Cardea SOLO|DEVICE: ActiGraph wGT3X-BT|DEVICE: Wavelet Wristband
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Investigate the Safety, Tolerability and Efficacy of HLX60 Combination With HLX10 in Subjects With Advanced or Metastatic Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced or Metastatic Solid Tumors
Interventions: BIOLOGICAL: HLX60 combined with HLX10
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of DWP14012 in Patients With Non-Erosive Gastroesophageal Reflux Disease (NERD)
Status: RECRUITING
Conditions: Non-erosive Reflux Disease|Non-Erosive Gastro-Esophageal Reflux Disease|Non-Erosive Esophageal Reflux Disease
Interventions: DRUG: DWP14012 20mg|DRUG: DWP14012 40mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Brentuximab Vedotin in Treating Patients With CD30+ Malignant Mesothelioma That Cannot Be Removed by Surgery
Status: RECRUITING
Conditions: CD30-Positive Neoplastic Cells Present|Malignant Mesothelioma
Interventions: DRUG: Brentuximab Vedotin|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double Blind, Placebo Controlled Study of Safety and Efficacy of Leronlimab in Patients With "Long" COVID-19
Status: COMPLETED
Conditions: Coronavirus Disease 2019
Interventions: DRUG: Placebos|DRUG: Leronlimab (700mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of an Individualized Impairment-based, Orthopedic Physical Therapy Intervention (IOI), on Muscle Stiffness, Pelvic Floor Function, and Pain in Women With Chronic Pelvic Pain
Status: UNKNOWN
Conditions: Pelvic Pain|Chronic Pain|Muscle Tightness
Interventions: PROCEDURE: Orthopedic Physical Therapy Intervention|DEVICE: Dry Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary Prevention of Allergic Disease in Early Child by Lactobacillus Reuteri
Status: COMPLETED
Conditions: Allergic Conditions
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of AHCC® for the Clearance of High Risk-HPV Infections in Chinese Female
Status: RECRUITING
Conditions: High Risk Human Papillomavirus Infection|Low Grade Squamous Intraepithelial Lesion
Interventions: DRUG: AHCC®capsules|DRUG: Simulation of AHCC®capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Electromyography of the Diaphragm With Ultrasound in Neonates and Children With Respiratory Support
Status: RECRUITING
Conditions: Ultrasound|Transcutaneous EMG|Diaphragm|Neonate
Interventions: DEVICE: Diaphragm ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nitrites, Exercise, and Peripheral Arterial Disease
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DRUG: Beetroot Juice (Beet-It Stamina Shot) & Supervised Exercise Training|OTHER: Placebo Comparator Beverage (Beet-It Stamina Shot) & Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Randomized, Open Label Study to Evaluate the Lipid Lowering Efficacy and Safety of Vytorin® 10/20 vs. Atorvastatin 10mg in Hypercholesterolemia Patients With Metabolic Syndrome in Korea (0653A-129)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: simvastatin (+) ezetimibe|DRUG: Comparator: atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Child of Urban Poverty Iron Project (CUPIP) - A Pilot Study
Status: COMPLETED
Conditions: Iron-deficiency|Iron Deficiency Anemia|Micronutrient Deficiency|Nutrient Deficiency|Stunting
Interventions: DIETARY_SUPPLEMENT: Vitamin and Mineral Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects Of Combination Therapy Of Statin And Ascorbic Acid For Prevention Of Contrast-Induced Nephropathy
Status: COMPLETED
Conditions: Contrast-induced Nephropathy|Statin|Ascorbic Acid|AKI
Interventions: DRUG: Atorvastatin-Ascorbic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial of Topical Photodynamic Therapy With 5-aminolevulinic Acid for the Treatment of Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: BF-200 ALA 1%|DRUG: BF-200 ALA 3%|DRUG: BF-200 ALA 10%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy in Premenopausal Women With Heavy Menstrual Bleeding (HMB) Associated With Uterine Fibroids (UF)
Status: COMPLETED
Conditions: Heavy Uterine Bleeding|Uterine Fibroids
Interventions: OTHER: Elagolix placebo|DRUG: Elagolix|DRUG: 0.5 mg estradiol / 0.1 mg norethindrone acetate|DRUG: 1 mg estradiol / 0.5 mg norethindrone acetate|DRUG: E2/NETA placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sapanisertib in Treating Patients With Metastatic or Refractory Pancreatic Neuroendocrine Tumor That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Pancreatic Neuroendocrine Tumor G1|Pancreatic Neuroendocrine Tumor G2|Refractory Pancreatic Neuroendocrine Carcinoma
Interventions: DRUG: Sapanisertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Nissen Versus Anterior Partial Fundoplication
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: PROCEDURE: Nissen fundoplication|PROCEDURE: Laparoscopic antireflux surgery ad modum Watson
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Investigate the Safety, Tolerability, and Pharmacokinetics of GR1603 in SLE
Status: RECRUITING
Conditions: Lupus Erythematosus, Systemic
Interventions: BIOLOGICAL: low dose GR1603 in phase Ⅰb|BIOLOGICAL: high dose GR1603 in phaseⅠb|BIOLOGICAL: low dose GR1603 in phase Ⅱ|BIOLOGICAL: high dose GR1603 in phase Ⅱ|BIOLOGICAL: Placebo in phase Ⅱ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Mediterranean Diet and Naltrexone/Bupropion Treatment in Obese Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer|Obesity|Overweight
Interventions: DRUG: naltrexone/bupropion|BEHAVIORAL: Mediterranean Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Meditation on Bothersome Tinnitus
Status: COMPLETED
Conditions: Tinnitus|Noise Induced Tinnitus|Tinnitus, Subjective|Tinnitus, Objective|Tinnitus Aggravated|Tinnitus, Pulsatile|Tinnitus, Spontaneous Oto-Acoustic Emission|Tinnitus, Clicking|Tinnitus, Tensor Tympani Induced
Interventions: BEHAVIORAL: Meditation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MyCompass in a Swedish Context - an Automated Self-help Intervention Targeting Mental Health Problems
Status: COMPLETED
Conditions: Mild Depression|Anxiety State|Sleep Disturbance|Stress, Psychological
Interventions: BEHAVIORAL: MyCompass|BEHAVIORAL: Comparison group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Direct Statin Comparison of LDL-C Values: an Evaluation of Rosuvastatin Therapy
Status: COMPLETED
Conditions: Hypercholesteremia
Interventions: DRUG: Rosuvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Gamification on Patients With Type 2 Diabetes
Status: RECRUITING
Conditions: Gamification|Type 2 Diabetes|Self-management|Digital Health|Mobile Application
Interventions: OTHER: Gamification and education with mobile game application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing of a 22G EUS Procore Fine Needle Biopsy Device and a 20G EUS Procore Fine Needle Biopsy Device
Status: UNKNOWN
Conditions: Pancreas Neoplasms
Interventions: DEVICE: Using 22G FNB, the first pass is SP|DEVICE: Using 22G FNB, the first pass is MWST|DEVICE: Using 20G FNB, the first pass is SP|DEVICE: Using 20G FNB, the first pass is MWST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 2 Study to Evaluate the Efficacy and Safety of SAR444656 Compared With Placebo in Adult Participants With Moderate to Severe Hidradenitis Suppurativa
Status: RECRUITING
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: SAR444656 (KT-474)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Midostaurin Efficacy and Safety in Newly Diagnosed Patients With FLT3-mutated AML
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Midostaurin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Boceprevir in End Stage Renal Disease (ESRD)
Status: WITHDRAWN
Conditions: Hepatitis C Infection|End Stage Renal Disease
Interventions: DRUG: P-IFN alfa 2a|DRUG: P-IFN alfa 2b|DRUG: Ribavirin|DRUG: Boceprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Intraocular Pressure (IOP) Lowering Efficacy of Low Dose Travoprost
Status: COMPLETED
Conditions: Open-angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Travoprost ophthalmic solution, 0.0008%|DRUG: Travoprost ophthalmic solution, 0.001%|DRUG: Travoprost ophthalmic solution, 0.0012%|DRUG: TRAVATAN|OTHER: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of CytoSorb Hemoperfusion Device on IL-6 Removal in ARDS/ALI Patients With Sepsis
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome|Acute Lung Injury|Sepsis
Interventions: DEVICE: CytoSorb Hemoperfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Anesthetic Efficacy of Mental Nerve Block Versus Inferior Alveolar Nerve Block in Mandibular Anterior Teeth and Premolars in Symptomatic Irreversible Pulpitis
Status: RECRUITING
Conditions: Symptomatic Irreversible Pulpitis
Interventions: PROCEDURE: inferior alveolar nerve block|PROCEDURE: mental nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of NeuroAD on the Cognitive Function of Alzheimer Patients
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DEVICE: TMS and cognitive stimulation|DEVICE: sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant FOLFOXIRI Versus CapeOX Chemotherapy for Local Advanced Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: DRUG: FOLFOXIRI|DRUG: CapeOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Smoking on Dimensional Changes of Free Gingival Graft Around Dental Implants
Status: COMPLETED
Conditions: Smoking|Free Gingival Graft|Dental Implant
Interventions: PROCEDURE: Free gingival graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Canola Oil on Vascular and Metabolic Parameters in Individuals With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: OTHER: Canola Oil 25 g/d|OTHER: Non-Canola Oil Mixture 25 g/d
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Randomized Study for Efficacy and Safety of Ranibizumab 0.5mg in Treat-extend and Monthly Regimens in Patients With nAMD
Status: COMPLETED
Conditions: Age-related Macular Degeneration|Choroidal Neovascularization
Interventions: DRUG: Ranibizumab 0.5mg|DRUG: Ranibizumab 0.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Influence of Surface Sealants on the Quality of Posterior Restorations With Bulk Fill Composites
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Restoration Failure of Marginal Integrity
Interventions: PROCEDURE: Bulk without surface sealant|PROCEDURE: Bulk with Biscover|PROCEDURE: Bulk with Permaseal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Feasibility, Safety and Tolerability of VR-based Audiovisual Stimulation
Status: RECRUITING
Conditions: Alzheimer Disease|Healthy Aging
Interventions: DEVICE: Audiovisual stimulation VR system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect Of DAAs For Treatment Of HCV On Normal Kidney
Status: UNKNOWN
Conditions: Antiviral Drug Adverse Reaction
Interventions: DRUG: Sofosbuvir 400 MG Oral Tablet,|DRUG: Ombitasvir/paritaprevir/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Randomised Trial Comparing Iron Supplementation Versus Placebo in the Treatment of Anaemia After Hip Fracture
Status: COMPLETED
Conditions: Hip Fracture
Interventions: DRUG: Ferrous sulphate tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Renal Effects of Two Iodinated Contrast Media in Patients at Risk Undergoing Coronary Angiography
Status: COMPLETED
Conditions: Coronary Artery Disease|Renal Impairment
Interventions: DRUG: Iodixanol 320 mgI/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Enamel Wear Evaluation in Patients With Different Ceramic Restorations
Status: UNKNOWN
Conditions: Wear, Tooth|Dental Wear|Prosthetic|Outcome
Interventions: PROCEDURE: Treatment with monolithic zirconia restorations|PROCEDURE: Treatment with lithium disilicate restorations|PROCEDURE: Treatment with metal ceramic restorations|PROCEDURE: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 TH-302 Mass Balance Trial
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: [14C] TH-302 (Label 1)|DRUG: [14C] TH-302 (Label 2)|DRUG: Unlabeled TH-302
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Finding the Optimal Regimen for Mycobacterium Abscessus Treatment
Status: RECRUITING
Conditions: Pulmonary Disease Due to Mycobacteria (Diagnosis)
Interventions: DRUG: Amikacin|DRUG: Tigecycline|DRUG: Imipenem|DRUG: Cefoxitin|DRUG: Azithromycin|DRUG: Clarithromycin|DRUG: Clofazimine|DRUG: Ethambutol|DRUG: Amikacin|DRUG: Linezolid|DRUG: co-trimoxazole|DRUG: Doxycycline|DRUG: Moxifloxacin|DRUG: Bedaquiline|DRUG: Rifabutin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-Dose Melphalan, Total-Body Irradiation, and Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma in First Relapse
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: filgrastim|DRUG: cyclophosphamide|DRUG: melphalan|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: low-LET cobalt-60 gamma ray therapy|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Trial to Determine the Immunomodulatory Activity of PTM-001 in Patients With Hidradenitis Suppurativa
Status: RECRUITING
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: PTM-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neostigmine and Glycopyrrolate for the Treatment of Headache After Dural Puncture
Status: RECRUITING
Conditions: Post-Dural Puncture Headache
Interventions: DRUG: Neostigmine|DRUG: Glycopyrrolate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modafinil - Escitalopram Study for Cocaine Dependence
Status: COMPLETED
Conditions: Cocaine Dependence|Cocaine Abuse|Cocaine Addiction|Substance Abuse
Interventions: DRUG: Modafinil and Escitalopram|DRUG: Placebo|DRUG: Modafinil|DRUG: Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Lenalidomide and Alvocidib in Treating Patients With Relapsed or Refractory B-cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Anemia|Chronic Lymphocytic Leukemia|Prolymphocytic Leukemia|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Thrombocytopenia
Interventions: DRUG: Alvocidib Hydrochloride|DRUG: Lenalidomide|OTHER: Pharmacological Study|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Responsive Study of Ringer's Lactate Solution in Prevention of Post-induction Hypotension
Status: RECRUITING
Conditions: Post Induction Hypotension
Interventions: OTHER: RL 10ml/kg|OTHER: RL 15ml/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Serum Concentrations of Antidepressant Drugs in Pregnant Women - a Naturalistic Study
Status: COMPLETED
Conditions: Pharmacokinetics|Antidepressive Agents|Pregnancy
Interventions: DRUG: sertraline, mirtazapine, venlafaxine, citalopram, escitalopram
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: S0219, Combination Chemotherapy Followed By Observation or Surgery in Patients With Stage II or Stage III Cancer of the Urothelium
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter|Urethral Cancer
Interventions: DRUG: carboplatin|DRUG: gemcitabine|DRUG: paclitaxel|PROCEDURE: surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retisert and Cataract Surgery in Patients With Severe Uveitis
Status: COMPLETED
Conditions: Intermediate Uveitis|Posterior Uveitis
Interventions: DEVICE: Retisert (fluocinolone acetonide implant)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral vs Initial Intravenous Antibiotic Treatment of Urinary Tract Infections in Children: a RCT
Status: TERMINATED
Conditions: Urinary Tract Infections
Interventions: DRUG: oral amoxicilline/clavulanic acid|DRUG: iv ceftriaxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crutch Use After Arthroscopic Hip Surgery
Status: COMPLETED
Conditions: Hip Fractures|Hip Injuries
Interventions: OTHER: 2 weeks of partial weight bearing on crutches|OTHER: 4 weeks of partial weight bearing on crutches
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study Comparing Blood Levels After Single-Dose Administration Of Artesunate Sachets (Pfizer) Versus Single-Dose Administration Of Arsuamoon® Tablets (Guilin-China) In Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: artesunate sachets|DRUG: Arsuamoon
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Study to Learn How the Medicine Called [14C] PF-06821497 is Taken up Into and Removed From the Body.
Status: NOT_YET_RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: Oral [14C] PF-06821497|DRUG: Oral PF-06821497|DRUG: IV [14C] PF-06821497
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Impact of Chokeberry Bioproducts on Metabolic Parameters and Antioxidant Potential
Status: COMPLETED
Conditions: Diet, Healthy|Diabetes Mellitus|Hypertension|Obesity|Hypercholesterolemia
Interventions: OTHER: Dietary intervention with chokeberry juices|OTHER: Dietary intervention with chokeberry juices and fibers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cytoreduction Followed by Normothermic Versus Hyperthermic Intraperitoneal Intraoperative Chemoperfusion (HIPEC): a Study in Peritoneal Carcinomatosis
Status: COMPLETED
Conditions: Peritoneal Carcinomatosis
Interventions: PROCEDURE: Hyperthermic intraoperative Peritoneal Chemoperfusion|PROCEDURE: Hyperthermic intraoperative Peritoneal Chemoperfusion|DRUG: Hyperthermic intraoperative Peritoneal Chemoperfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-Blind, Alacramyn® vs. Placebo in Pediatric Patients
Status: COMPLETED
Conditions: Scorpion Sting Envenomation
Interventions: BIOLOGICAL: Antivenin Centruroides (scorpion) equine immune F(ab)2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EndocardialVascularEndothelialGrowth Factor D(VEGF-D)Gene Therapy for the Treatment of Severe Coronary Heart Disease
Status: COMPLETED
Conditions: Angina Pectoris|Myocardial Infarction
Interventions: BIOLOGICAL: VEGF-D gene transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Alirocumab and Reverse Cholesterol Transport
Status: COMPLETED
Conditions: Atherosclerosis|Coronary Heart Disease
Interventions: DRUG: Alirocumab|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Open Trial of Technology-Enhanced Behavioral Intervention for Buprenorphine Retention in Pregnant and Postpartum People
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder|Pregnancy Related
Interventions: BEHAVIORAL: Empowering Pregnant Women and People Receiving Medications for Opioid Use Disorder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Health in Pediatric Crohn's Disease: A Low Magnitude Mechanical Stimulus Trial
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DEVICE: Low magnitude mechanical stimulus|DEVICE: Placebo (inactive) low magnitude mechanical stimulus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RS-fMRI to Nutrient Shakes
Status: COMPLETED
Conditions: Pleasure
Interventions: OTHER: Glucose|OTHER: Fructose|OTHER: Sucralose|OTHER: Allulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever)
Status: COMPLETED
Conditions: Visceral Leishmaniasis|Human African Trypanosomiasis|Enteric Fever|Melioidosis|Brucellosis|Leptospirosis|Relapsing Fever|Rickettsial Diseases|HIV|Tuberculosis|Malaria|Amoebic Liver Abscess
Interventions: DEVICE: rk28 ICT|DEVICE: IT LEISH (rK39)|DEVICE: Immunochromatographic HAT test|DEVICE: HAT Serostrip|DEVICE: Card Agglutination Trypanosoma Test (CATT)-10|DEVICE: Typhidot M|DEVICE: S. typhi IgM/IgG|DEVICE: Test-it Typhoid IgM|DEVICE: Test-it Leptospirosis IgM|DEVICE: Leptospira IgG/IgM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: T-DM1 With or Without Abemaciclib for the Treatment of HER2-Positive Metastatic Breast Cancer
Status: WITHDRAWN
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|HER2 Positive Breast Carcinoma|Metastatic Breast Carcinoma|Prognostic Stage IV Breast Cancer AJCC v8
Interventions: DRUG: Abemaciclib|BIOLOGICAL: Trastuzumab Emtansine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of AKST4290 With Aflibercept in Patients With Newly Diagnosed nAMD
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: AKST4290|DRUG: Placebo|DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin or Carboplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Lung Adenocarcinoma|Lung Large Cell Carcinoma|Lung Non-Squamous Non-Small Cell Carcinoma|Stage III Lung Cancer AJCC v8
Interventions: DRUG: Carboplatin|DRUG: Cisplatin|PROCEDURE: Computed Tomography|BIOLOGICAL: Durvalumab|PROCEDURE: FDG-Positron Emission Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Methoxyamine|DRUG: Pemetrexed|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Quality of Life in Subjects With Chronic or High-frequency Episodic Migraine and Associated Comorbidities Treated With Erenumab
Status: WITHDRAWN
Conditions: Migraine
Interventions: DRUG: erenumab 70mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immediate Dentoalveolar Restoration Compared to Bio-oss
Status: COMPLETED
Conditions: Fresh Sockets With Buccal Resorption
Interventions: PROCEDURE: Immediate dentoalveolar restoration|PROCEDURE: Demineralized bovine bone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pain Management After Minimally Invasive Aortic Valve Surgery
Status: COMPLETED
Conditions: Aortic Valve Surgery|Postoperative; Pain
Interventions: DRUG: Piritramid|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Decline and Underlying Mechanisms in Asymptomatic Intracranial Artery Stenosis Patients
Status: RECRUITING
Conditions: Asymptomatic Intracranial Stenosis|Cognitive Impairment|Cerebrovascular Event
Interventions: DRUG: Aspirin Tablet, Clopidogrel Bisulfate Tablets and Atorvastatin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Efficacy and Safety of Maralixibat in Subjects With Progressive Familial Intrahepatic Cholestasis (MARCH-PFIC)
Status: COMPLETED
Conditions: Progressive Familial Intrahepatic Cholestasis (PFIC)
Interventions: DRUG: Maralixibat|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Family Meetings in the Pediatric Cardiac Intensive Care Unit
Status: COMPLETED
Conditions: Communication|Critical Illness
Interventions: BEHAVIORAL: CICU Team And Loved Ones Communicating (CICU TALC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Attenuation of D-dimer Using Vorapaxar to Target Inflammatory and Coagulation Endpoints
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: vorapaxar|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Sho-saiko-to, a Herbal Formula, in Reducing Viral Load in Hepatitis C
Status: WITHDRAWN
Conditions: Hepatitis C Virus
Interventions: DRUG: standardized herbal formula, Sho-saiko-to (SST)|OTHER: placebo capsule identical to the active herbal formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Avastin and Doxorubicin Postoperatively for Patients With Anaplastic Thyroid Cancer
Status: TERMINATED
Conditions: Thyroid Neoplasms|Carcinoma|Thyroid Cancer|Metastatic Cancer
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Investigate the Efficacy of OPC-41061 Administered at a Dose of 7.5 mg in Patients With Hepatic Edema
Status: COMPLETED
Conditions: Cirrhosis
Interventions: DRUG: OPC-41061|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics That Moderate pH and Antagonize Pathogens to Promote Oral Health
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Caries
Interventions: OTHER: Caries Free 1.5% Arginine|OTHER: Caries Free Placebo Sodium Fluoride|OTHER: Caries Active 1.5% Arginine|OTHER: Caries Active- Placebo Sodium Fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study on the Prognosis and Effect of Anti-diabetic Drugs on Type-2 Diabetes Mellitus With Coronary Artery Disease
Status: COMPLETED
Conditions: Type 2 Diabetes|Coronary Artery Disease
Interventions: DRUG: Glipizide|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Overweight
Interventions: DRUG: Tirzepatide|DRUG: Semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functionality and Neurocognition in Patients With Bipolar Disorder After a Physical-exercise Program (FINEXT-BD Study)
Status: UNKNOWN
Conditions: Bipolar Disorder
Interventions: OTHER: Physical exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx)
Status: RECRUITING
Conditions: Pleural Effusion, Malignant|Ascites, Malignant|Carcinoma|Carcinoma, Hepatocellular|Carcinoma, Renal Cell|Carcinoma, Renal|Carcinoma, Small Cell|Carcinoma, Non-Small-Cell Lung|Carcinoma, Pancreatic Ductal|Carcinoma, Neuroendocrine|Carcinoma, Thymic|Carcinoma, Pancreatic|Carcinoma Breast|Carcinoma, Ovarian|Carcinoma Bladder|Carcinoma of Unknown Primary|Carcinoma of the Head and Neck|Carcinoma of the Oropharynx|Carcinoma of the Larynx|Carcinoma of the Bladder|Carcinoma of Esophagus|Carcinoma of the Nasopharynx|Carcinoma of the Penis|Carcinoma of the Cervix|Carcinoma of the Anus|Carcinoma of the Vulva|Carcinoma of the Appendix|Carcinoma of the Oral Cavity|Cholangiocarcinoma|Melanoma|Mesothelioma|Pancreatic Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cisplatin, Bevacizumab, and Intensity-Modulated Radiation Therapy in Treating Patients With Stage III or Stage IV Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: cisplatin|PROCEDURE: conventional surgery|RADIATION: intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Memory-Enriched T Cells in Treating Patients With Recurrent or Refractory Grade III-IV Glioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma|Malignant Glioma|Recurrent Glioma|Refractory Glioma|WHO Grade III Glioma
Interventions: BIOLOGICAL: HER2(EQ)BBζ/CD19t+ T cells|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Leukapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Light Therapy to Improve Symptoms in Pregnant Women With Major Depressive Disorder
Status: UNKNOWN
Conditions: Major Depressive Disorder
Interventions: DEVICE: bright light|DEVICE: dim red light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Relapsed T-cell Acute Lymphoblastic Leukemia or T-lymphoblastic Lymphoma With MabCampath
Status: COMPLETED
Conditions: Adult Acute Lymphocytic Leukemia T-cell|Lymphoma, Lymphoblastic
Interventions: DRUG: Alemtuzumab (MabCampath)|DRUG: Cladribine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis|Multiple Sclerosis, Relapsing-Remitting|Multiple Sclerosis, Secondary Progressive
Interventions: OTHER: Acute Intermittent Hypoxia|OTHER: Sham Acute Intermittent Hypoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Approach in Colchicine-resistant Recurrent pEricarditis in Children
Status: NOT_YET_RECRUITING
Conditions: Pericarditis
Interventions: DRUG: Anakinra|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continued Activity During Rehabilitation in Patients With Patellar Tendinopathy
Status: COMPLETED
Conditions: Patellar Tendinopathy|Patellar Tendinitis|Patellar Tendon Pain|Patellar Tendinosis|Jumper's Knee
Interventions: OTHER: Exercise Treatment|OTHER: Pain- Guided Activity Modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of Laser Doppler Vibrometer (LDV) for Measurement of Arterial Stiffness in Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DEVICE: PWV measurement by LDV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER