pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparison of the Effectiveness of Two Medical Compression Bandage Application Techniques by Measuring Interface Pressures Depending on Whether or Not the Heel is Included in Patients With Open Venous Ulcers
Status: COMPLETED
Conditions: Venous Ulcer
Interventions: OTHER: Heel-free bandage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Method of Securing Skin Graft: A Comparison of Vacuum Assisted Closure Device Versus Bolster Dressing
Status: COMPLETED
Conditions: Skin Graft Detachment
Interventions: OTHER: VAC and bolster dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Nicotinamide Riboside in Prevention of Small Fiber Axon Degeneration and Promotion of Nerve Regeneration
Status: COMPLETED
Conditions: Small Fiber Neuropathy
Interventions: DRUG: Nicotinamide riboside|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose Dense MVAC for Muscle Invasive Bladder Cancer
Status: COMPLETED
Conditions: Muscle Invasive Bladder Cancer|High Risk Urothelial Carcinoma of the Upper Urinary Tracts
Interventions: DRUG: single arm dose dense MVAC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robotic Resection for Patients With Gastric Gastrointestinal Stromal Tumors: a Single-center Study
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumor of Stomach
Interventions: PROCEDURE: Robotic gastric gastrointestinal stromal tumors resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adaptive Tyrosine Kinase Inhibitor (TKI) Therapy In Patients With Thyroid Cancer
Status: TERMINATED
Conditions: Thyroid Cancer|Thyroid Cancer, Medullary|Differentiated Thyroid Cancer|Papillary Thyroid Cancer|Follicular Thyroid Cancer|Poorly Differentiated Thyroid Gland Carcinoma
Interventions: DRUG: Lenvatinib|DRUG: Sorafenib|DRUG: Cabozantinib|DRUG: Vandetanib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Enteropathogenic Escherichia Coli (EPEC): Does it Have a Role in Colorectal Tumourigenesis?
Status: COMPLETED
Conditions: Enteropathogenic Escherichia Coli .|Colorectal Carcinoma
Interventions: OTHER: colonoscopic biopsies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Is Spironolactone Safe and Effective in the Treatment of Cardiovascular Disease in Mild Chronic Renal Failure?
Status: COMPLETED
Conditions: Chronic Kidney Disease|Cardiovascular Disease
Interventions: DRUG: Spironolactone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EEG Alpha/Theta Neurofeedback to Reduce Trait Anxiety
Status: COMPLETED
Conditions: Anxiety
Interventions: BEHAVIORAL: Neurofeedback training|BEHAVIORAL: Sham comparator: Sham neurofeedback training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Probiotic Toothpaste for Microbial Colonization
Status: UNKNOWN
Conditions: Microbial Colonization
Interventions: OTHER: Streptococcus salivarius M18 toothpaste|OTHER: Streptococcus salivarius M18 toothpaste|OTHER: Streptococcus salivarius M18 toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ergonomic Brace Wear for Adolescent Idiopathic Scoliosis
Status: COMPLETED
Conditions: Adolescent Idiopathic Scoliosis
Interventions: DEVICE: Ergonomic Brace vs hard brace
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: WX-0593 Combined With Concurrent Chemoradiotherapy in Unresectable Locally Advanced NSCLC
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: DRUG: WX-0593 Tablets|DRUG: chemotherapy|RADIATION: Thoracic Radiation Therapy（TRT）
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Comparison of Pediatric I-gel, Air-Q With Classic Laryngeal Mask Airway
Status: COMPLETED
Conditions: Anesthesia
Interventions: DEVICE: LMA Classic|DEVICE: i- gel|DEVICE: Air-Q
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Lidocaine Patch for Lower Limb Amputation Pain
Status: WITHDRAWN
Conditions: Phantom Limb Pain (PLP)|Primary/Secondary Scar Hyperalgesia
Interventions: DRUG: Lidocaine|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Fluorouracil and/or Pegfilgrastim in Treating Women With Node-Positive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: BIOLOGICAL: pegfilgrastim|DRUG: cyclophosphamide|DRUG: epirubicin hydrochloride|DRUG: fluorouracil|DRUG: paclitaxel|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Treatment Effect of Belnacasan in Patients With COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Belnacasan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PET Imaging of Subjects Using 124I-PU-AD
Status: TERMINATED
Conditions: Lymphoma|Solid Malignancy|Alzheimer Disease|Myeloma
Interventions: DRUG: PU-AD|DEVICE: PET Scan|OTHER: Blood Draws
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial of Oral Melatonin in Elevated Blood Pressure
Status: UNKNOWN
Conditions: Elevated Blood Pressure
Interventions: DRUG: Placebo oral capsule/placebo comparator|DRUG: Melatonin/experimental
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis
Status: RECRUITING
Conditions: Obesity|Cardiovascular Diseases|Hypertension|Nocturnal Blood Pressure|Natriuretic Peptides|Renin-Angiotensin-Aldosterone System
Interventions: DRUG: Sacubitril-Valsartan 49 Mg-51 Mg Oral Tablet|DRUG: Valsartan 80 mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: CD19 CAR-T Therapy for Patients With B-cell Non-Hodgkin's Lymphoma
Status: RECRUITING
Conditions: Non-hodgkin Lymphoma,B Cell
Interventions: DRUG: CD19 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Tc 99m Tilmanocept Localization in Primary Cutaneous Kaposi's Sarcoma and Lymphatic Drainage by SPECT/CT
Status: COMPLETED
Conditions: Kaposi's Sarcoma
Interventions: DRUG: Tc 99m tilmanocept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The ENROUTE Transcarotid Neuroprotection System (ENROUTE Transcarotid NPS) DW-MRI Evaluation
Status: COMPLETED
Conditions: Carotid Artery Diseases|Carotid Atherosclerosis|Carotid Stenosis|Carotid Artery Plaque|Carotid Disease
Interventions: PROCEDURE: Transcarotid Revascularization (TCAR)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Optimal Time of IV Dexamethasone Administration for Prolongation of Peripheral Nerve Block
Status: COMPLETED
Conditions: Peripheral Nerve Block Prolongation|Hand Injury Wrist
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Post Operative Pain in Modified Radical Mastectomy.
Status: UNKNOWN
Conditions: Post Operative Pain
Interventions: DRUG: capule gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Remote ECG Monitoring of TAVI Patients
Status: UNKNOWN
Conditions: Cardiac Valve Disease|Aortic Valve Stenosis
Interventions: DEVICE: mobile Cardiac Arrhythmia Diagnostics Service (m-CARDS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Moving Well for Total Knee Arthroplasty (TKA)
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: BEHAVIORAL: Moving Well|BEHAVIORAL: Staying Well
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combined Optokinetic Stimulation and Cueing-based Reading Therapy to Treat Hemispatial Neglect Following Stroke
Status: COMPLETED
Conditions: Spatial Neglect
Interventions: BEHAVIORAL: Optokinetic stimulation and cueing-based reading therapy (OKS-READ)|BEHAVIORAL: General neuropsychological treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Pilates Stretching on Flexibility, Strength, Power and Muscular Endurance
Status: COMPLETED
Conditions: Young Adults|Performance|Exercise
Interventions: OTHER: Traditional Pilates|OTHER: Pilates without stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Interest of Serratus Plane Block in Postoperative Analgesia for Robot-assisted Surgery
Status: COMPLETED
Conditions: Analgesia|Robotic Surgery
Interventions: DRUG: 0.5% levobupivacaine injectable solution with 10 ml of physiological saline|DRUG: 0.5% levobupivacaine injectable solution with 10 ml of physiological saline|DRUG: 0.5% levobupivacaine injectable solution with physiological saline|DRUG: 0.5% levobupivacaine injectable solution with physiological saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of ACP-104: To Demonstrate the Safety, Tolerability, and Pharmacokinetics
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: ACP-104|DRUG: ACP-104|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Single-arm, Dose-escalation Trial of Long-acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopathic CD4 Lymphopenia
Status: RECRUITING
Conditions: Idiopathic CD4 Lymphopenia
Interventions: DRUG: Recombinant human interleukin (IL) 7-hyFc
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Trial of Ketamine for the Treatment of Rett Syndrome
Status: TERMINATED
Conditions: Rett Syndrome
Interventions: PROCEDURE: Intravenous infusion|PROCEDURE: Intravenous infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of AL-034 to Evaluate the Safety, Tolerability and Pharmacokinetics of Single and Multiple Doses in Healthy Participants
Status: COMPLETED
Conditions: Hepatitis B
Interventions: DRUG: AL-034|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Metformin on Biomarkers of Colorectal Tumor Cell Growth
Status: TERMINATED
Conditions: Colorectal Neoplasms
Interventions: DRUG: Placebo|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laser Visual Internal Urethrotomy With Versus Without Paclitaxel Injection
Status: COMPLETED
Conditions: Urethral Stricture, Male
Interventions: PROCEDURE: Ho-YAG Laser Visual internal urethrotomy|PROCEDURE: Ho-YAG Laser Visual internal urethrotomy combined with intralesional submucosal injection of Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral Roflumilast Taken Once Daily in Patients Older Than 40 Years With Chronic Obstructive Pulmonary Disease (BY217/M2-119)
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Roflumilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Treatment of 2 Chinese Medicines in Clozapine-induced Hypersalivation in Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia|Clozapine|Hypersalivation|Traditional Chinese Medicine
Interventions: DRUG: Suo Quan Wan, Wu Lin San|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety Evaluation of Clopidogrel Sulfate in Patients With Peripheral Arterial Disease
Status: COMPLETED
Conditions: Peripheral Arterial Disease (PAD)
Interventions: DRUG: clopidogrel (SR25990)|DRUG: ticlopidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transcranial Alternating Current Stimulation for the Improvement of Episodic Memory in Healthy Older Adults
Status: NOT_YET_RECRUITING
Conditions: Healthy Older Adults
Interventions: DEVICE: Gamma tACS (40 Hz) over the precuneus|DEVICE: Sham tACS over the precuneus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A TQT Study to Evaluate the Electrocardiographic Effects of Carbidopa in Healthy Subjects
Status: COMPLETED
Conditions: Cardiac Repolarization in Healthy Subjects
Interventions: DRUG: Carbidopa capsule|DRUG: Moxifloxacin Tablets, USP|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Dacarbazine and Bortezomib in Melanoma and Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Melanoma|Soft Tissue Sarcoma|Parathyroid Carcinoma|Small Cell Carcinoma of the Lung|Carcinoid Tumors
Interventions: DRUG: Dacarbazine and bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tesetaxel as Second-line Therapy for Patients With Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Adenocarcinoma of the Stomach|Adenocarcinoma of Esophagogastric Junction
Interventions: DRUG: Tesetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of IM Letrozole ISM® Pharmacokinetics, Safety, and Tolerability in Healthy Post-menopausal Women (LISA-1)
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DRUG: Letrozole ISM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Role of Nitric Oxide in the Impact of Aging on Myocardial Remodeling
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DRUG: L-NAME|DRUG: L-Arginine|DRUG: Phenylephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety,Efficacy and Pharmacokinetics Evaluation of SCT800 in Previously Treated Paediatric Patients With Severe Haemophilia A.
Status: UNKNOWN
Conditions: Hemophilia A
Interventions: DRUG: Recombinant Human Coagulation FVIII
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: RF Ablation of Treatment of Metastatic Lesions in Patients Undergoing Antiangiogenic Therapy for Stage IV Renal Cell Carcinoma
Status: WITHDRAWN
Conditions: Renal Cell Carcinoma
Interventions: PROCEDURE: Radiofrequency Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Century Clot-Guided Prophylactic Rivaroxaban for Post STEMI Complicating Left Ventricular Thrombus
Status: RECRUITING
Conditions: STEMI - ST Elevation Myocardial Infarction
Interventions: DRUG: NOAC+DAPT|DRUG: DAPT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Proof-of Concept Study of Topical 3%-Diclofenac-Nano-Emulsion Cream for Knee OA Pain
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: 3%-Diclofenac-Nano-Emulsion Cream|DRUG: Placebo cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Efficacy and Safety of Ruxolitinib in Participants With COVID-19-Associated ARDS Who Require Mechanical Ventilation (RUXCOVID-DEVENT)
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Placebo|DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Initial Versus Delayed PDT Combination With Conbercept in PCV
Status: COMPLETED
Conditions: Polypoidal Choroidal Vasculopathy
Interventions: DRUG: conbercept|PROCEDURE: Initial PDT|PROCEDURE: Delayed PDT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of First Line DRC +/- Bortezomib for Patients With Waldenström's Macroglobulinemia
Status: COMPLETED
Conditions: Waldenström's Macroglobulinemia
Interventions: DRUG: Dexamethasone, Rituximab, Cyclophosphamide|DRUG: Dexamethasone, Rituximab, Cyclophosphamide, Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Residual Hypermethylation in Early Stage Non-Small Cell Lung Cancer (NSCLC) As Part of Adjuvant Therapy and Preventive Strategy
Status: COMPLETED
Conditions: Lung Cancer|Non Small Cell Lung Carcinoma|Hypermethylation
Interventions: DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Vidaza|PROCEDURE: Tumor Specimen for Methylation Analysis|PROCEDURE: Blood Sample for Methylation Analysis|DRUG: Vinorelbine|DRUG: Docetaxel|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Correction of Wrinkles and Folds and Safety of YVOIRE Classic Versus Restylane in Nasolabial Fold Intradermal Injection
Status: COMPLETED
Conditions: Temporary Correction of Wrinkles
Interventions: DEVICE: HA IDF (YVOIRE classic)|DEVICE: Restylane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Site, Randomized, Double-blind, Placebo Controlled Trial of NIC5-15 in Subjects With Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease|Dementia
Interventions: DRUG: Drug: NIC5-15|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Structural-functional Connectome in Drug-resistant Epilepsies and Neurodevelopmental Syndromes With Epilepsy
Status: RECRUITING
Conditions: Epilepsy|Angelman Syndrome|Dup15q Syndrome
Interventions: DIAGNOSTIC_TEST: High Density EEG recording|DIAGNOSTIC_TEST: Rey Complex Figure Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Raloxifene Augmentation in Patients With a Schizophrenia Spectrum Disorder
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder|Psychosis NOS
Interventions: DRUG: Raloxifene|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Feasibility and Clinical Relevance of Liquid Biopsy in Patients With Suspicious Metastatic Lung Cancer
Status: COMPLETED
Conditions: Metastatic Lung Cancer
Interventions: DIAGNOSTIC_TEST: InvisionFirst® molecular panel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cluster-Randomized Trial of Air Filtration and Ventilation to Reduce Covid19 Spread in Homes
Status: ENROLLING_BY_INVITATION
Conditions: Covid19
Interventions: DEVICE: Filtration Fan|BEHAVIORAL: Safe-home pamphlet|BEHAVIORAL: Mid-week phone call
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Short- Versus Long-duration Tourniquet Use During Total Knee Replacement (TKR)
Status: TERMINATED
Conditions: Arthroplasty, Replacement, Knee
Interventions: PROCEDURE: Long duration tourniquet|PROCEDURE: Short duration tourniquet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prevention of Ischemic Conditions in Non-disabling Stroke/Transient Ischemic Attack With Remote Ischemic Conditioning
Status: COMPLETED
Conditions: Transient Ischemic Attack|Non-disabling Stroke
Interventions: DEVICE: Remote Ischemic Conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis
Status: COMPLETED
Conditions: Acute, Perforated Appendicitis
Interventions: DRUG: Povidone-iodine irrigation|PROCEDURE: No irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: High Intensity Interval Training in Chronic Heart Failure
Status: RECRUITING
Conditions: Chronic Heart Failure|Cardiac Rehabilitation
Interventions: BEHAVIORAL: Cardiac rehabilitation comprised aerobic exercise on a treadmill accompanied by an electrocardiogram monitoring device and a blood pressure monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aruba Aloe Formula F-BC-096 in the Treatment of Split Thickness Donor Site After Wound Closure
Status: COMPLETED
Conditions: Wounds
Interventions: OTHER: Nivea Cream for scar hydration|OTHER: Aloë Vera FORMULA F-BC-096 for scar hydration|OTHER: Eucerin Calming cream for scar hydration|OTHER: Aloë Vera with modified preservative for scar hydration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation of Critically Ill Patients With SARS-CoV-2 Variants in ICU With Limited Resources
Status: UNKNOWN
Conditions: COVID-19 Acute Respiratory Distress Syndrome
Interventions: OTHER: Functional Rehabilitation|OTHER: Neuromuscular Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Ankle Block Versus Medial Forefoot Block for Forefoot Surgery
Status: COMPLETED
Conditions: Pain Relief After Forefoot Surgery
Interventions: PROCEDURE: Ultrasound guided ankle block|PROCEDURE: Medial forefoot block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of 25 and 50 mg Proellex® in the Treatment of Women With Symptomatic Uterine Fibroids
Status: TERMINATED
Conditions: Uterine Fibroids
Interventions: DRUG: Proellex|DRUG: Proellex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interventional Ventricular Assist System for PCI in CHIP Patients
Status: RECRUITING
Conditions: High-Risk Percutaneous Coronary Intervention (High-risk PCI)|Left Ventricular Assist Devices
Interventions: DEVICE: CorVad|DEVICE: VA-ECMO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ancillary Study of the Lessening Incontinence With Low-impact Activity Study
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: BEHAVIORAL: Yoga Practice Program|BEHAVIORAL: Physical Conditioning Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Measurement of Expiratory Flow Variability for the Detection of Bronchospasm in Infants Using the Ventica® Device by Revenio
Status: UNKNOWN
Conditions: Healthy, Wheezing, Non Wheezing Acute Respiratory Episode
Interventions: DEVICE: Ventica® device from Revenio
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Heparin Like Effect in Acute Variceal Bleeding
Status: UNKNOWN
Conditions: Coagulation Disorder|Cirrhosis, Liver|Variceal Hemorrhage
Interventions: DIAGNOSTIC_TEST: SONOCLOT, coagulation factor assays for VIII/X, XIII, TPA/ PAI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, PK, and Efficacy of Omecamtiv Mecarbil in Japanese Subjects With Heart Failure With Reduced Ejection Fraction
Status: COMPLETED
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: 25 mg Omecamtiv Mecarbil|DRUG: Placebo|DRUG: 37.5 mg Omecamtiv Mecarbil|DRUG: 50 mg Omecamtiv Mecarbil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of P. Vivax Malaria During Pregnancy in Bolivia
Status: WITHDRAWN
Conditions: Malaria
Interventions: DRUG: Chloroquine profilaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Studies of Temozolomide in Combination With Topotecan in Refractory and Relapsed Paediatric Solid Tumours
Status: COMPLETED
Conditions: Neuroblastoma|Brain Tumors|Solid Tumors
Interventions: DRUG: Temozolomide/Hycamtin (Topotecan)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fruits, Vegetables, and Whole Grains: A Community-based Intervention
Status: COMPLETED
Conditions: Heart Disease|Diabetes|Hypertension
Interventions: BEHAVIORAL: No further instruction|BEHAVIORAL: Food Delivery|BEHAVIORAL: Fruits (F), vegetables (V), and whole grain (WG) counseling|BEHAVIORAL: Counseling to reduce soft drink intake.|BEHAVIORAL: Food Delivery & F, V & WG counseling.|BEHAVIORAL: Food delivery & soft drink counseling|BEHAVIORAL: F, V, WG & soft drink counseling|BEHAVIORAL: Food delivery and F,V, WG & soft drink counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [SOCRATES -Acute Stroke Or Transient IsChaemic Attack TReated With Aspirin or Ticagrelor and Patient OutcomES]
Status: COMPLETED
Conditions: Acute Ischaemic Stroke|Transient Ischaemic Attack
Interventions: DRUG: ticagrelor|DRUG: Acetylsalicylic acid (ASA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Predilatation Between Self-expanding Valves
Status: COMPLETED
Conditions: Aortic Stenosis
Interventions: DEVICE: Transcatheter Aortic Valve Implantation with ACURATE NEO/TF|DEVICE: Transcatheter Aortic Valve Implantation with Medtronic CoreValve /Evolut R/Pro
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Evaluation of Pitaya Ovule Extract on Skin
Status: COMPLETED
Conditions: Skin Condition
Interventions: DIETARY_SUPPLEMENT: Placebo drink|DIETARY_SUPPLEMENT: Pitaya Ovule Extract Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: China Angioplasty & Stenting for Symptomatic Intracranial Severe Stenosis
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: PROCEDURE: Intracranial stenting group|DRUG: medical group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 12-Week Study of DS-8500a in Subjects With Type 2 Diabetes Mellitus on Metformin
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin 100 mg|DRUG: DS-8500a 25mg|DRUG: Placebo Tablet|DRUG: Placebo Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study Comparing Conversion Rate to Surgery With Hepatic Arterial Infusion Chemotherapy to Systemic Chemotherapy in Patients With Non Resectable Liver-only Colorectal Metastases
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: intra-arterial oxaliplatin + Systemic FOLFIRI + target agent (bevacizumab or cetuximab) every 2 weeks|DRUG: IV FOLFIRI+ target agent (bevacizumab or cetuximab) every 2 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection of SLN in Patients With Endometrial Cancer Undergoing Robotic Assisted Staging: Comparison of ISB and ICG
Status: COMPLETED
Conditions: Endometrial Cancer
Interventions: DEVICE: ISB dye and standard white light imaging|DEVICE: ICG dye and FireFly fluorescence imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Back to Basics - Effects, Narratives and Routes of Administration of Open-label Placebo
Status: COMPLETED
Conditions: Placebo Effect|Pain|Expectancy
Interventions: OTHER: open-label placebo|OTHER: deceptive placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Laser Therapy for At-Home Treatment of DIabetic Foot Ulcers
Status: UNKNOWN
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: B-Cure Pro|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan Hydrochloride With FOLFIRI and Cetuximab as First-Line Therapy in Treating Patients With RAS Wild-Type Colorectal Cancer
Status: WITHDRAWN
Conditions: Stage IVA Colorectal Cancer|Stage IVB Colorectal Cancer
Interventions: BIOLOGICAL: Cetuximab|DRUG: Fluorouracil|DRUG: Irinotecan Hydrochloride|DRUG: Leucovorin Calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Davunetide for the Treatment of Progressive Supranuclear Palsy
Status: COMPLETED
Conditions: Progressive Supranuclear Palsy
Interventions: DRUG: Davunetide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Brief Physiotherapy Informed by Acceptance and Commitment Therapy for Chronic Low Back Pain: the PACT Study
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: BEHAVIORAL: Physiotherapy informed by Acceptance and Commitment Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Streptococcus Mutans Cariogenicity by Real-time PCR in High Caries Risk Patients
Status: COMPLETED
Conditions: Streptococcus Mutans|High Caries Risk Patients
Interventions: DRUG: cinnamon extract mouthwash|DRUG: chlorohexidine based mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Brain Stimulation and Meditation for Pain After Total Knee Arthroplasty
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: active tDCS paired with active MBM|DEVICE: sham tDCS paired with sham MBM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Capillary Carbon Dioxide Partial Pressure (pCO2) While Wearing FFP2 / FFP3 Masks
Status: COMPLETED
Conditions: Hypercapnia
Interventions: OTHER: No mask|DEVICE: Filtering face mask 2 (FFP2)|DEVICE: Filtering face mask 3 (FFP3)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Development of a Software Correlating Simultaneously fMRI, EEG and Peripheral Physiological Activity
Status: COMPLETED
Conditions: Music Listening
Interventions: DEVICE: simultaneous fMRI and EEG + peripheral measures|DEVICE: EEG and peripheral measures
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Role of the Fibroblast Activation Protein (FAP) as Biomarker of Fibrotic Lung Diseases
Status: RECRUITING
Conditions: Pulmonary Fibrosis|Lung Fibrosis|Idiopathic Pulmonary Fibrosis|FAP
Interventions: DIAGNOSTIC_TEST: FAPI PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Effect of Nigella Sativa and Conventional Management for OSMF
Status: COMPLETED
Conditions: Oral Submucous Fibrosis
Interventions: DIETARY_SUPPLEMENT: Nigella sativa oil|DRUG: Betamethasone Valerate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of 1550nm Fractional Laser Treatment for Acne Scars in Fitzpatrick Type IV-VI Skin
Status: COMPLETED
Conditions: Acne Scarring
Interventions: PROCEDURE: Fractionated Laser Resurfacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-nasal Ketorolac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease
Status: NOT_YET_RECRUITING
Conditions: Post Operative Pain|Urolithiasis|Ureter Calculi|Stent Complication
Interventions: DRUG: intra-nasal ketorolac|DRUG: oral diclofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SBRT-based PArtial Tumor Irradiation of HYpoxic Segment
Status: TERMINATED
Conditions: Bystander Effect|Abscopal Effect|Unresectable Malignant Solid Neoplasm|Bulky Tumors
Interventions: RADIATION: SBRT-PATHY (SBRT-based PArtial Tumor irradiation targeting HYpoxic segment)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase IIa Vorinostat (MK0683, Suberoylanilide Hydroxamic Acid (SAHA)) Study in Lower Risk Myelodysplastic Syndromes (0683-064)
Status: TERMINATED
Conditions: Myelodysplastic Syndromes|Blood Disease|Bone Marrow Disease
Interventions: DRUG: vorinostat|DRUG: vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Screening Emotions in Adolescents at the Hospital for mTBI
Status: RECRUITING
Conditions: Brain Injury Traumatic Mild|Brain Injuries|Brain Injuries, Acute|Head Injury With Intracranial Hemorrhage|Head Injury Trauma|Brain Injury Traumatic Focal With Loss of Consciousness|Skull Fractures|Diffuse Axonal Injury|Intracranial Hemorrhages|Head Injury
Interventions: BEHAVIORAL: Validated Questionnaires|BEHAVIORAL: Questionnaires|OTHER: Clinician / Medical Record Variables
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adoptive Cell Therapy Using Cancer Specific CD8+ Tumor Infiltrating Lymphocytes in Adult Patients With Solid Tumors
Status: RECRUITING
Conditions: HNSCC|Melanoma|Gynecologic Cancer|Colorectal Cancer|Lung Cancer|Urogenital Cancer
Interventions: BIOLOGICAL: DP CD8 TIL|BIOLOGICAL: DP CD8 TIL KD|BIOLOGICAL: Low dose IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Personalized Exercise Program and Trimetazidine in Rehabilitation of Patients After RFA of AF
Status: COMPLETED
Conditions: Atrial Fibrillation Paroxysmal
Interventions: OTHER: Physical training program|DRUG: Trimetazidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Investigate the Regional Drug Absorption of KUC-7483 CL Administered Via an Enterion™ Capsule Compared to an Immediate Release Formulation in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: KUC 7483 CL, immediate release tablet|DRUG: KUC 7483 CL, particulate formulation|DRUG: KUC 7483 CL, solution formulation|DEVICE: Enterion™ capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on the Effect of Mepolizumab Therapy on Daily Physical Activity of Patients With Severe Eosinophilic Asthma
Status: UNKNOWN
Conditions: Severe Eosinophilic Asthma
Interventions: DRUG: Mepolizumab 100 MG Injection [Nucala]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Evaluating the Safety, Tolerability, and Effect on Microvascular Obstruction of Intravenous Temanogrel in Adult Participants Undergoing Percutaneous Coronary Intervention
Status: TERMINATED
Conditions: Microvascular Obstruction
Interventions: DRUG: Temanogrel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sonography for COVID-19 Vaccines Related Reactive Lymphadenopathy
Status: COMPLETED
Conditions: Reactive Axillary Lymphadenopathy for SARS-CoV-2 Vaccines in the Asian Taiwanese Population
Interventions: BIOLOGICAL: the AstraZeneca ChAdOx1 (AZ) vaccine, Moderna mRNA-1273 (Moderna) vaccine, and Pfizer-BioNTech BNT162b2 (BNT) vaccine.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: HALO: A Single Arm Prospective Investigation of the SJM™ Masters HP™ 15mm Rotatable Mechanical Heart Valve
Status: COMPLETED
Conditions: Mitral Valve Disease|Damaged Mitral Valve|Malfunctioning Mitral Heart Valve|Mitral Valve Replacement
Interventions: DEVICE: Mitral valve replacement SJM™ Masters HP™ 15mm Rotatable Mechanical Heart Valve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Capsular Tension Ring Implantation on Intraocular Lens Position
Status: RECRUITING
Conditions: Cataract|High Myopia
Interventions: PROCEDURE: phacoemulsification combined with IOL and CTR implantation|PROCEDURE: phacoemulsification combined with IOL implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Predilatation Technique for BVS Implantation
Status: UNKNOWN
Conditions: Coronary Artery Stenosis
Interventions: DEVICE: Predilatation with non-compliant balloon|DEVICE: Predilatation with scoring balloon (Scoroflex)|DEVICE: Predilatation with cutting balloon (Flextome)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hematology, IMG-7289, LSD1 (Lysine-Specific Demethylase 1) Inhibitor, Essential Thrombocythemia (ET), Ph 2
Status: ACTIVE_NOT_RECRUITING
Conditions: Thrombocythemia, Essential
Interventions: DRUG: IMG-7289
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Switching From Dolutegravir and ABC/3TC or ABC/DTG/3TC to B/F/TAF in HIV-1 Infected Adults Who Are Virologically Suppressed
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: ABC/DTG/3TC|DRUG: B/F/TAF|DRUG: ABC/DTG/3TC Placebo|DRUG: B/F/TAF Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Basal Insulin Glargine Combination With Exenatide Bid vs Aspart30 in T2DM
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: glargine + exenatide|DRUG: aspart 30
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0722: Everolimus in Treating Patients With Pleural Malignant Mesothelioma That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Malignant Mesothelioma
Interventions: DRUG: everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NanoKnife Low Energy Direct Current (LEDC) System in Subjects With Locally Advanced Unresectable Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma
Interventions: DEVICE: NanoKnife Low Energy Direct Current (LEDC) System Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MIC Cell Therapy for Individualized Immunosuppression in Living Donor Kidney Transplant Recipients
Status: COMPLETED
Conditions: Kidney Failure, Chronic
Interventions: BIOLOGICAL: Mitomycin C-induced peripheral blood mononuclear cells (MICs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Non-invasive Diagnosis of Pulmonary Embolism by Use of Biomarkers in Exhaled Breath
Status: RECRUITING
Conditions: Pulmonary Embolism
Interventions: DIAGNOSTIC_TEST: New method for diagnosis of pulmonary embolism (PE) in order to validate/consolidate 151 putative identified biomarkers for PE in the exhaled breath.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Oxytocin Antagonist on Reduction of Uterine Contractions
Status: COMPLETED
Conditions: In Vitro Fertilisation (IVF) Treatment
Interventions: DRUG: Barusiban|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Osseodensification and Dental Implant Stability
Status: UNKNOWN
Conditions: Osseointegration|Osseodensification
Interventions: DEVICE: Densah Burs|DEVICE: Conventional Burs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of ESPB on Postoperative Pain in Patients With Breast Cancer Implant Reconstruction
Status: COMPLETED
Conditions: Mammary Cancer|Erector Spinae Plane Block|Postoperative Pain
Interventions: PROCEDURE: Erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 18F-Fluorodopamine PET Studies of Neuroblastoma and Pheochromocytoma
Status: RECRUITING
Conditions: Neuroblastoma|Pheochromocytoma
Interventions: DRUG: 18F-DA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Placebo and Active Controlled Study of Rivoglitazone in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Rivoglitazone|DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT