pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of Brain Stimulation During Nocturnal Sleep on Memory Consolidation in Younger, Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DEVICE: brain stimulation|DEVICE: SHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase IB/II Study of Alectinib Combined With Cobimetinib in Advanced ALK-Rearranged (ALK+) NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Alectinib|DRUG: Cobimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Pomegranate Extract on Chronic Cardiomyopathy Complicated by Renal Insufficiency (ImPrOVE): a Pilot Study
Status: TERMINATED
Conditions: Cardiomyopathy|Heart Failure
Interventions: DRUG: POMx, pomegranate polyphenol extract|DRUG: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Human Fresh Corneal Lenticule Implantation Criteria in Progressive Corneal Disease Using Relex-Smile
Status: ENROLLING_BY_INVITATION
Conditions: Progressive Disease of Corneae
Interventions: DEVICE: ReLex-smile
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect on Blood Flow Using the FlowOx™ Device in Patients With Reduced Peripheral Circulation in the Lower Leg
Status: UNKNOWN
Conditions: Periferal Arterial Occlusive Disease, PAOD
Interventions: DEVICE: FlowOx
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Cetuximab and Bevacizumab as First-Line Therapy Followed By Combination Chemotherapy and Bevacizumab With or Without Cetuximab as Second-Line Therapy in Treating Patients With Stage IV Colorectal Cancer
Status: WITHDRAWN
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: bevacizumab|BIOLOGICAL: cetuximab|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ticagrelor And PrEconditioning in Patients With coronaRy Artery diSease
Status: COMPLETED
Conditions: Myocardial Ischemia
Interventions: PROCEDURE: Coronary stenting|PROCEDURE: intracoronary ECG recording|PROCEDURE: Coronary Flow reserve|PROCEDURE: Index of Microcirculatory Resistance|PROCEDURE: Fractional Flow Reserve
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Calcium and High-dose Vitamin D Supplementation on Bone Mineral Density Among HIV-infected Children and Adolescents
Status: COMPLETED
Conditions: Adverse Bone Health|HIV Infection
Interventions: DIETARY_SUPPLEMENT: High dose vitamin D and calcium|DIETARY_SUPPLEMENT: Normal dose vitamin D and calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Elucidate the Effect of Mesenchymal Stem Cells on the T Cell Repertoire of the Kidney Transplant Patients
Status: UNKNOWN
Conditions: Renal Transplant Rejection
Interventions: BIOLOGICAL: Mesenchymal Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Amivantamab|DRUG: Lazertinib|DRUG: Doxycycline|DRUG: Minocycline|DRUG: Clindamycin|DRUG: Chlorhexidine|OTHER: Noncomedogenic skin moisturizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NeoFOL-R Trial (Perioperative Versus Adjuvnat FOLFIRINOX in Resectable Pancreatic Cancer)
Status: NOT_YET_RECRUITING
Conditions: Resectable Pancreatic Cancer|Neoadjuvant Chemotherapy|Effects of Chemotherapy
Interventions: DRUG: Folfirinox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Different Insulin Dosing Algorithms Using Hepatic Directed Vesicle-Insulin Lispro and Insulin Degludec
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: HDV-Insulin Lispro and Insulin Degludec (-40%)|DRUG: HDV-Insulin Lispro and Insulin Degludec (-10%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Talabostat Combined With Temozolomide or Carboplatin in Treating Young Patients With Relapsed or Refractory Brain Tumors or Other Solid Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Childhood Germ Cell Tumor|Kidney Cancer|Liver Cancer|Neuroblastoma|Ovarian Cancer|Sarcoma|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: carboplatin|DRUG: talabostat mesylate|DRUG: temozolomide|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Subjects With Open-angle Glaucoma, Pseudoexfoliative Glaucoma, or Ocular Hypertension Naïve to Medical and Surgical Therapy, Treated With Two Trabecular Micro-bypass Stents (iStent Inject) or Travoprost
Status: COMPLETED
Conditions: Open-angle Glaucoma
Interventions: DEVICE: iStent inject|DRUG: Travoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Cetuximab in Nasopharyngeal Carcinoma (NPC) With Chemoradiotherapy
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: C225 (cetuximab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab for Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)
Status: COMPLETED
Conditions: Systemic Sclerosis-Associated PAH
Interventions: BIOLOGICAL: Rituximab|OTHER: Placebo|DIAGNOSTIC_TEST: CMRI|DRUG: prednisone|DRUG: methylprednisolone|DRUG: diphenhydramine|DRUG: acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SAFE Study - Septal Pacing for Atrial Fibrillation Suppression Evaluation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Pacemaker implantation with RA lead in LAS position|DEVICE: Pacemaker implantation with RA lead in LAS position|DEVICE: Pacemaker implantation with RA lead in RAA position|DEVICE: Pacemaker implantation with RA lead in RAA position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ciprofloxacin Versus an Aminoglycoside Followed by Ciprofloxacin for Bubonic Plague
Status: RECRUITING
Conditions: Plague, Bubonic|Plague, Pneumonic
Interventions: DRUG: Ciprofloxacin|DRUG: Streptomycin|DRUG: Gentamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Platelet-Rich Plasma" Epidural Injection an Emerging Strategy in Lumbar Disc Herniation
Status: COMPLETED
Conditions: PRP
Interventions: DRUG: platelet rich plasma|DRUG: Triamcinolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Summers Non-Pesticide Lice Asphyxiator (L.A.)for the Treatment of Head Lice
Status: COMPLETED
Conditions: Head Lice
Interventions: DRUG: 5% Lice Asphyxiator lotion - Summers Laboratories, Inc.
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Ibuprofen Versus Codeine. Is One Better for Post-operative Pain Relief Following Reduction of Paediatric Forearm Fractures?
Status: UNKNOWN
Conditions: Fracture|Pain
Interventions: DRUG: Acetaminophen and Ibuprofen|DRUG: Acetaminophen and Codeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparing Performance of Simplified Mid-Upper Arm Circumference Devices ("Click-MUACs") to Detect Acute Malnutrition
Status: UNKNOWN
Conditions: Malnutrition
Interventions: DEVICE: Click-MUAC prototype & regular MUAC tape
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Immunogenicity of High-Dose Quadrivalent Influenza Vaccine in Participants ≥65 Years in the US
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: QIV-HD|BIOLOGICAL: Licensed TIV-HD1|BIOLOGICAL: Investigational TIV-HD2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Superselective Adrenal Arterial Embolization for Refractory Hypertension: A Proof-of-Concept Study
Status: RECRUITING
Conditions: Essential Hypertension
Interventions: PROCEDURE: Superselective adrenal arterial embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Motivational Interviewing to Address Suicidal Ideation for Veterans at High Risk for Suicide
Status: RECRUITING
Conditions: Suicide, Attempted|Suicidal Ideation
Interventions: BEHAVIORAL: Motivational Interviewing to Address Suicidal Ideation- Revised (MI-SI-R)|OTHER: Enhanced usual care (EUC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reliability of Measuring Conditioned Pain Modulation With the Nociceptive Withdrawal Reflex
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DEVICE: Conditioned Pain Modulation|DEVICE: Conditioned Pain Modulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Reduce Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed Multiple Myeloma
Status: TERMINATED
Conditions: Recurrent Plasma Cell Myeloma
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Cyclophosphamide|BIOLOGICAL: Daratumumab|DRUG: Fludarabine|DRUG: Melphalan|DRUG: Mycophenolate Mofetil|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laboratory Studies on Oxytocin for Treatment of Alcohol Use Disorder
Status: COMPLETED
Conditions: Alcoholism|Alcohol Related Disorders
Interventions: DRUG: oxytocin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Upper-Extremity Plyometric Combined Strength Training in Overhead Athletes With Shoulder Instability
Status: RECRUITING
Conditions: Glenohumeral Subluxation|Shoulder Subluxation|Shoulder Instability Subluxation Bilateral
Interventions: PROCEDURE: Plyometric and strengthening exercises|PROCEDURE: Strengthening exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Monthly And Twice Monthly Subcutaneous Dosing Of PF-04950615 (RN316) In Hypercholesterolemic Subjects On A Statin
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: PBO|DRUG: 200mg PF-04950615 (RN316)|DRUG: 300mg PF-04950615 (RN316)|DRUG: PBO|DRUG: PF-04950615|DRUG: PF-04950615|DRUG: PF-04950615
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Nano-hydroxyapatite-Containing Toothpastes for Relief of Dentin Hypersensitivity
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: OTHER: Placebo|DEVICE: 15% nano-HAP toothpaste|DEVICE: 5% KNO3 toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Cryoanalgesia for Extended Pain Management Following Thoracotomy
Status: UNKNOWN
Conditions: Chronic Post-thoracotomy Pain|Acute Post-thoracotomy Pain|Post-thoracotomy Pain Syndrome
Interventions: PROCEDURE: Thoracic Epidural|PROCEDURE: Intercostal Cryoanalgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Curative D2 vs D1 Lymphadenectomy in Operable Gastric Carcinoma
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: PROCEDURE: D1 lymphadenectomy|PROCEDURE: D2 lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Neurocircuitry of Autism- fMRI and Transcranial Magnetic Stimulation Studies
Status: TERMINATED
Conditions: Autism Spectrum Disorder|Asperger Disorder|Pervasive Developmental Disorder
Interventions: DEVICE: TMS and functional MRI (Magstim)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Long-term Antibody Persistence of GlaxoSmithKline (GSK) Biologicals' MenACWY-TT Vaccine (GSK134612) Versus Mencevax ACWY in Healthy Adolescents and Adults and Booster Response to MenACWY-TT Vaccine Administered at 10 Years Post-primary Vaccination
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: Meningococcal vaccine GSK134612
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Accelerated Corneal Collagen Crosslinking Protocols
Status: ACTIVE_NOT_RECRUITING
Conditions: Keratoconus
Interventions: PROCEDURE: Accelerated crosslinking (ACXL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pathological Comparisons of Surgical Open Lung Biopsies and Cryobiopsies in Non-IPF ILD
Status: COMPLETED
Conditions: Non Definite IPF|Interstitial Lung Diseases
Interventions: PROCEDURE: Lung cryobiopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prospective Study: The Effect on Clinical Outcome After Treatment of MTP Cartilage Lesions in Hallux Valgus Surgery
Status: UNKNOWN
Conditions: Hallux Valgus|Cartilage Damage
Interventions: PROCEDURE: Debridement of the MTP1 cartillage lesion and microfracture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vildagliptin Compared to Glimepiride in Combination With Metformin in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: vildagliptin|DRUG: glimepiride|DRUG: Metformin|DRUG: Vildagliptin matching placebo|DRUG: Glimepiride matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modified Pre-operative Oral Doses Acetaminophen Versus Intravenous Acetaminophen
Status: COMPLETED
Conditions: Tonsillectomy|Adenoidectomy
Interventions: DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of MRI and CEDM to Evaluate Treatment Response Before Surgery
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DIAGNOSTIC_TEST: Breast Magnetic Resonance Imaging (MRI)|DIAGNOSTIC_TEST: Contrast Enhanced Mammography (CEDM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparation Between Needles for EUS-guided Sampling of Solid Pancreatic Lesions
Status: UNKNOWN
Conditions: Pancreatic Neoplasms
Interventions: DEVICE: needle punction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Magnesium Sulphate on Analgesia Following Knee Arthroplasty
Status: UNKNOWN
Conditions: Knee Arthroplasty, Total|Postoperative Pain
Interventions: DRUG: Magnesium Sulfate|PROCEDURE: continuous femoral nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Myofascial Release in Cerebral Palsy Children
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: myofascial release and quick icing|OTHER: myofascial release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Efficacy and Safety of Tenofovir Disoproxil Fumarate and Entcavir in Treatment of Chronic Hepatitis B Patients in Upper Egypt
Status: RECRUITING
Conditions: Chronic Hepatitis b Patients
Interventions: DRUG: Tenofovir Disoproxil Fumarate and Entcavir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Group A Beta Hemolytic Streptococcal Pharyngitis in Children in Low Resource Settings
Status: COMPLETED
Conditions: Streptococcal Infections|Pharyngitis
Interventions: DRUG: Penicillin G, Benzathine|DRUG: Amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Potential for Gastric-pH Dependent Drug-Drug Interactions of BIIB122 With a Proton Pump Inhibitor in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: BIIB122|DRUG: Rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Atrial Fibrillation Suppression By Nerve Stimulation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DEVICE: DUCEST Neurostimulator V Group A|DEVICE: DUCEST Neurostimulator V Group B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Interprofessional Learning and Simulation on Healthy Aging in Undergraduate Medical and Nursing Program
Status: UNKNOWN
Conditions: Healthy Aging|Interprofessional Relations|Education, Professional
Interventions: OTHER: IPSE program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Oral E5501 Plus Standard of Care for the Treatment of Thrombocytopenia in Adults With Chronic Immune Thrombocytopenia (Amendment 02)
Status: COMPLETED
Conditions: Chronic Thrombocytopenia|Immune Thrombocytopenia
Interventions: DRUG: Avatrombopag|DRUG: Placebo|DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Stem Cells Implantation Combined With Coronary Bypass Grafting in Patients With Ischemic Cardiomyopathy
Status: COMPLETED
Conditions: Coronary Artery Disease|Ischemic Cardiomyopathy
Interventions: PROCEDURE: Intramyocardial implantation of of a novel mesenchymal precursor cell type (iMP).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closed-loop Control of Penicillin Delivery
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DEVICE: Microneedle array|DEVICE: Microneedle array and closed-loop control of penicillin delivery|DRUG: Penicillin G_1200mg|DRUG: Penicillin G_2400mg|DRUG: Penicillin G_600mg/hr
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Mechanism of Action of Vichy Catalan Water
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DIETARY_SUPPLEMENT: Bicarbonated mineral water|DIETARY_SUPPLEMENT: Mineral water low in mineral content (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Palliative Care for Elderly Outpatients
Status: COMPLETED
Conditions: Cancer Terminal
Interventions: BEHAVIORAL: Dignity Therapy - Nurse Led|BEHAVIORAL: Usual care|BEHAVIORAL: Dignity Therapy - Chaplain Led
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Repetitive TMS of the Posterior DMN in AD
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: DEVICE: REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interaction of BI 425809 With Midazolam, Warfarin, Omeprazole and Digoxin
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Midazolam|DRUG: Warfarin|DRUG: Omeprazole|DRUG: Midazolam|DRUG: Digoxin|DRUG: BI 425809
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Vaccine Therapy With mRNA- Transfected Dendritic Cells in Patients With Advanced Malignant Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: BIOLOGICAL: Dendritic Cells (DC) malignant melanoma|PROCEDURE: IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eltanexor and Venetoclax in Relapsed or Refractory Myelodysplastic Syndrome and Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Relapsed Myelodysplastic Syndrome|Refractory Myelodysplastic Syndrome|Acute Myeloid Leukemia|Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Eltanexor|DRUG: Venetoclax|PROCEDURE: Bone Marrow Aspiration and Biopsy|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Peripheral Stem Cell Transplantation Followed by Surgery and/or Radiation Therapy in Treating Young Patients With Advanced Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: mesna|DRUG: vincristine sulfate|PROCEDURE: conventional surgery|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: low-LET cobalt-60 gamma ray therapy|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Making Maternal Post-partum Vitamin A Supplementation Effective: The Role of Timing and Inflammation
Status: COMPLETED
Conditions: Healthy Women Giving Birth to Singleton Infants
Interventions: DIETARY_SUPPLEMENT: vitamin A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Posoleucel (ALVR105,Viralym-M) for Multi-Virus Prevention in Patients Post-Allogeneic Hematopoietic Cell Transplant
Status: TERMINATED
Conditions: Adenovirus Infection|BK Virus Infection|Cytomegalovirus Infections|Epstein-Barr Virus Infections|Human Herpes Virus-6 Infection|JC Virus Infection
Interventions: BIOLOGICAL: Posoleucel (ALVR105)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, Pharmacokinetics and Efficacy of AMG 397 in Subjects With Selected Relapsed or Refractory Hematological Malignancies
Status: TERMINATED
Conditions: Multiple Myeloma|Acute Myeloid Leukemia|Non-Hodgkins Lymphoma|Myelodysplastic Syndrome|AML|MDS|NHL
Interventions: DRUG: AMG 397|DRUG: Dexamethasone|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Extension Clinical Study of TQC2731 Injection in the Treatment of Chronic Sinusitis With Nasal Polyps
Status: RECRUITING
Conditions: Chronic Rhinosinusitis With Nasal Polyps
Interventions: DRUG: 210mg of TQC2731 injection|DRUG: 420mg of TQC2731 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Bifidobacterium Longum 1714® in a Population With Low Mood
Status: COMPLETED
Conditions: Low Mood|Depressive Symptoms
Interventions: DIETARY_SUPPLEMENT: Bifidobacterium longum 1714® strain|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Capecitabine and Vorinostat in Treating Patients With Recurrent and/or Metastatic Head and Neck Cancer
Status: TERMINATED
Conditions: Paranasal Sinus Squamous Cell Carcinoma|Recurrent Hypopharyngeal Squamous Cell Carcinoma|Recurrent Laryngeal Squamous Cell Carcinoma|Recurrent Oral Cavity Squamous Cell Carcinoma|Recurrent Oropharyngeal Squamous Cell Carcinoma|Stage IVA Hypopharyngeal Squamous Cell Carcinoma|Stage IVA Laryngeal Squamous Cell Carcinoma|Stage IVA Oral Cavity Squamous Cell Carcinoma|Stage IVA Oropharyngeal Squamous Cell Carcinoma|Stage IVB Hypopharyngeal Squamous Cell Carcinoma|Stage IVB Laryngeal Squamous Cell Carcinoma|Stage IVB Oral Cavity Squamous Cell Carcinoma|Stage IVB Oropharyngeal Squamous Cell Carcinoma|Stage IVC Hypopharyngeal Squamous Cell Carcinoma|Stage IVC Laryngeal Squamous Cell Carcinoma|Stage IVC Oral Cavity Squamous Cell Carcinoma|Stage IVC Oropharyngeal Squamous Cell Carcinoma
Interventions: DRUG: Capecitabine|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shared Decision Making in the Emergency Department: Chest Pain Choice Trial
Status: COMPLETED
Conditions: Chest Pain|Acute Coronary Syndrome
Interventions: OTHER: Chest Pain Choice Decision Aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: IV Busulfan Plus Bortezomib Conditioning Regimen for Second Autologous Stem Cell Transplant in Multiple Myeloma Patients
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: IV busulfan|DRUG: bortezomib|PROCEDURE: Autologous Hematopoietic Stem Cell Transplant (HSCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selumetinib With or Without Temsirolimus in Treating Patients With Metastatic, Recurrent, or Locally Advanced Soft Tissue Sarcoma That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Recurrent Adult Soft Tissue Sarcoma|Stage III Adult Soft Tissue Sarcoma|Stage IV Adult Soft Tissue Sarcoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Selumetinib|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of CD79B Mutant Relapsed/Refractory Diffuse Large B-Cell Lymphoma With Bruton Tyrosine Kinase Inhibitor Zanubrutinib
Status: RECRUITING
Conditions: Relapsed Diffuse Large B-cell Lymphoma|Refractory Diffuse Large B-cell Lymphoma
Interventions: DRUG: Zanubrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breath Gas Measurement of Propofol During Anesthesia in Patients With Endourological Procedures
Status: COMPLETED
Conditions: Urological Disease
Interventions: DEVICE: Drug: Propofol Anesthesia Patients will undergo propofol anesthesia.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Coenzyme Q10 Supplementation on Multi-Organ Dysfunction in Severely Burned Patients
Status: WITHDRAWN
Conditions: Multiple Organ Failure
Interventions: DIETARY_SUPPLEMENT: CoQ10|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Intraoperative Beta Blocker for Morbid Obese Patients Undergoing Laparoscopic Bariatric Surgery
Status: UNKNOWN
Conditions: Intraoperative Awareness|Postoperative Pain
Interventions: DRUG: Esmolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Diet Challenge in G6PD Deficient Egyptian Children: A One- Year Prospective Single Center Study With Genotype - Phenotype Correlation
Status: UNKNOWN
Conditions: Glucose-6-Phosphate Dehydrogenase Deficiency
Interventions: DIETARY_SUPPLEMENT: non- fava beans
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Subacromial Injection With Glutamate Receptor Antagonist, Ketamine, Attenuate Pain in Rotator Cuff Tendinopathy?
Status: RECRUITING
Conditions: Rotator Cuff Tendinitis|Chronic Pain
Interventions: DRUG: Ketalar|DRUG: NaCl 9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Penile Fracture: A Comparison of Erectile Function After Immediate Repair Versus Delayed Repair
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: PROCEDURE: Immediate repair|PROCEDURE: Delayed repair|DRUG: Lidocaine|DRUG: Ceftriaxone|DRUG: Diclofenac Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on the Safety and Effectiveness of Tislelizumab Combined With Axitinib for Neoadjuvant Treatment of ccRCC
Status: ACTIVE_NOT_RECRUITING
Conditions: Neoadjuvant Therapy
Interventions: DRUG: tislelizumab combined with axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Switching From Regimens Consisting of a Ritonavir-boosted Protease Inhibitor (PI) and Two Nucleoside Reverse Transcriptase Inhibitors (NRTIs) to a Fixed-dose Tablet Containing Emtricitabine/Rilpivirine/Tenofovir DF
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: FTC/RPV/TDF|DRUG: PI|DRUG: RTV|DRUG: NRTIs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on the Safety, Reactogenicity and Immune Response of a Vaccine Against Influenza in Healthy Younger and Older Adults
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: GSK4382276A Dose level 1|BIOLOGICAL: GSK4382276A Dose level 2|BIOLOGICAL: GSK4382276A Dose level 3|BIOLOGICAL: GSK4382276A Dose level 4|BIOLOGICAL: GSK4382276A Dose level 6|BIOLOGICAL: GSK4382276A Dose level 7|BIOLOGICAL: GSK4382276A Dose level 8|BIOLOGICAL: GSK4382276A Dose level 9|BIOLOGICAL: GSK4382276A Dose level 10|BIOLOGICAL: GSK4382276A Dose level 11|COMBINATION_PRODUCT: FDQ21A-NH|COMBINATION_PRODUCT: FDQ22A-NH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Novel Inhibitors of Lipolysis in the Treatment of Lipid a Glucose Metabolism in Obstructive Sleep Apnea Syndrome
Status: RECRUITING
Conditions: Obstructive Sleep Apnea|Obesity
Interventions: PROCEDURE: Dietary and physical intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Self-Adhesive Bulk-Fill Composite Versus Conventional Nano-hybrid Composite in Cervical Cavities
Status: RECRUITING
Conditions: Cervical Caries
Interventions: COMBINATION_PRODUCT: Self-Adhesive Bulkfill Composite (Surefil One)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glibenclamide in Aneurysmatic Subarachnoid Hemorrhage
Status: UNKNOWN
Conditions: Subarachnoid Hemorrhage, Aneurysmal
Interventions: DRUG: Glibenclamide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Reducing Nephrotoxicity of Vancomycin: A Prospective Study of Continuous Versus Intermittent Infusion of Vancomycin
Status: UNKNOWN
Conditions: Infections Requiring Prolonged Duration (>10 Days) of Vancomycin
Interventions: DRUG: continuous vancomycin infusion|DRUG: intermittent vancomycin infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of AZD3427 in Participants With Heart Failure and Pulmonary Hypertension Group 2
Status: RECRUITING
Conditions: Pulmonary Hypertension (World Health Organization Group 2)|Heart Failure
Interventions: DRUG: AZD3427|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Using Pupillometry to Measure Nociception in Healthy Volunteers.
Status: UNKNOWN
Conditions: Nociceptive Pain|Pupillary Light Reflex Lost|Healthy|Pain, Procedural|Gender|Anxiety
Interventions: DEVICE: CE marked medical device|DEVICE: Algometer|PROCEDURE: Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Post-Embolic Rhythm Detection With Implantable Versus External Monitoring
Status: COMPLETED
Conditions: Stroke|Atrial Fibrillation|Arrhythmias, Cardiac
Interventions: DEVICE: Medtronic Reveal LINQ|DEVICE: Sorin Spiderflash-t
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bictegravir/Emtricitabine/Tenofovir Alafenide Plus Doravirine
Status: COMPLETED
Conditions: HIV-1-infection
Interventions: DRUG: Bictegravir/emtricitabine/tenofovir alafenamide + Doravirine switch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin Type A (Dysport) Associated With Rehabilitation Treatment in Patients With Primary Myofascial Pain Syndrome
Status: COMPLETED
Conditions: Myofascial Pain Syndromes
Interventions: BIOLOGICAL: Botulinum toxin type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: TRT in Combination With Electrical Stimulation and Standing: Effect on Muscle and Bone in Spinal Cord Injured Males
Status: UNKNOWN
Conditions: Spinal Cord Injury
Interventions: DRUG: Testosterone Gel applied by a pump|OTHER: Stand Training|DEVICE: Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: French Assessment of the Relay Plus and Relay NBS Plus Thoracic Stent-Graft
Status: ACTIVE_NOT_RECRUITING
Conditions: Pathology of the Thoracic Aorta|Aneurysm Thoracic|Pseudo-aneurysm, Thoracic|Dissection of Thoracic Aorta|Intramural Haematoma of Thoracic Aorta|Penetrating Ulcer of Aorta (Disorder)|Rupture of the Isthmus
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Examination of the Lipid Metabolism of the Liver After Choline Substitution in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis Liver Disease
Interventions: DRUG: Choline Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of X0002 Following Escalating Single and Multiple Doses Administered as Topical Application in Healthy Volunteers
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: X0002|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage IV Wilms' Tumor
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage III Kidney Wilms Tumor|Stage IV Kidney Wilms Tumor
Interventions: RADIATION: 3-Dimensional Conformal Radiation Therapy|PROCEDURE: Conventional Surgery|DRUG: Cyclophosphamide|BIOLOGICAL: Dactinomycin|DRUG: Doxorubicin Hydrochloride|DRUG: Etoposide|DRUG: Vincristine Sulfate Liposome
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Losartan and Benazepril in Diabetic Hypertensive Patients Not Controlled by Amlodipine
Status: COMPLETED
Conditions: Hypertension|Diabetes Mellitus
Interventions: DRUG: Benazepril|DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Post Tpa-Iv Monitoring in Ischemic Stroke
Status: RECRUITING
Conditions: Acute Ischemic Stroke Patients Receiving Reperfusion Therapy
Interventions: OTHER: Low-intensity monitoring strategy|OTHER: Guideline recommended standard monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chemotherapy or Not, Following Complete Treatment of Hepatic Cancer in Cirrhotic Patients
Status: TERMINATED
Conditions: Liver Neoplasms|Liver Cirrhosis|Carcinoma, Hepatocellular|Recurrence|Neoplasm Recurrence, Local
Interventions: DRUG: Oxaliplatin, gemcitabine, cisplatin, lipiodol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ovarian Rejuvenation for Premature Ovarian Insufficiency and Poor Ovarian Response
Status: COMPLETED
Conditions: Ovarian Failure|Infertility, Female
Interventions: OTHER: intra-ovarian platelet rich plasma injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 0 /II Study of Ribociclib (LEE011) in Combination With Everolimus in Preoperative Recurrent High-Grade Glioma Patients Scheduled for Resection
Status: COMPLETED
Conditions: Glioblastoma Multiforme|Glioma of Brain
Interventions: DRUG: Ribociclib|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Japan PhI/II of GSK2118436 and GSK1120212 Combination in Subjects With BRAF V600E/K Mutation Positive Advanced Solid Tumors (Phase I Part) or Cutaneous Melanoma (Phase II Part)
Status: COMPLETED
Conditions: Solid Tumours
Interventions: DRUG: dabrafenib|DRUG: trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3, 12-week, Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of 2 Fixed Doses of Brexpiprazole in the Treatment of Alzheimer's Agitation
Status: COMPLETED
Conditions: Agitation Associated With|Alzheimer's Disease|Alzheimer's Type|Mental Disorder|Nervous System Diseases
Interventions: DRUG: Brexpiprazole, OPC-34712|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Program ACTIVE II: Behavioral Depression Treatment for Type 2 Diabetes
Status: COMPLETED
Conditions: Type2 Diabetes|Depression
Interventions: BEHAVIORAL: Program ACTIVE Exercise|BEHAVIORAL: Program ACTIVE CBT|BEHAVIORAL: Program ACTIVE|BEHAVIORAL: Usual Care - No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study Between Fluticasone Propionate 250 mcg and Salmeterol Xinafoate 50 mcg Inhalation Powder/Respirent Pharmaceuticals vs. ADVAIR DISKUS® 250/50 Inhalation Powder/GSK in Healthy Volunteers
Status: UNKNOWN
Conditions: Bioequivalence|Asthma
Interventions: DRUG: Test|DRUG: Reference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: This is a 2-year Follow-up Study to Evaluate the Long-term Effects in Patients Who Completed the Study CRAD001A2307.
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: Everolimus (RAD001)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study in Participants With Major Depressive Disorder Who Are Partial Responders to Selective Serotonin Reuptake Inhibitor
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: LY2216684|DRUG: Placebo|DRUG: SSRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Plasma Protein Binding and PK/PD of Total and Unbound Temocillin Non-ICU Patients
Status: UNKNOWN
Conditions: Pharmacokinetics|Antibacterial Agents|Infections, Bacterial|Infection|Drug Monitoring|Temocillin
Interventions: DRUG: temocillin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bioequivalence Study of Nexvax2 in Subjects With Celiac Disease
Status: COMPLETED
Conditions: Celiac Disease|Intestinal Disease|Malabsorption Syndromes|Gastrointestinal Disease|Digestive System Diseases|Metabolic Disease|Coeliac Disease|Gluten Sensitivity
Interventions: BIOLOGICAL: Nexvax2|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study for the Evaluation of the Safety, Tolerability, and Efficacy of ARX-F02 (Sufentanil NanoTab) Compared to Placebo in the Treatment of Cancer Breakthrough Pain
Status: COMPLETED
Conditions: Cancer|Pain
Interventions: DRUG: Sublingual sufentanil NanoTabs™ and placebo NanoTabs™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers for Tuberous Sclerosis Complex (BioTuScCom)
Status: TERMINATED
Conditions: Hypomelanotic Macules|Facial Angiofibroma|Shagreen Patches|Ungual Fibromas|Cortical Dysplasia|Cardiac Rhabdomyoma|Lymphangioleiomyomatosis|Renal Angiomyolipoma|Subependymal Giant Cell Astrocytoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study in Healthy Volunteers to Assess the Pharmacokinetics of Midazolam Administered Alone and in Combination With Vandetanib
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Midazolam|DRUG: vandetanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Biosynthetic Absorbable Mesh vs Standard of Repair for the Surgical Treatment of Infected Incisional Hernia
Status: RECRUITING
Conditions: Ventral Hernia Repair
Interventions: PROCEDURE: Incisional hernia repair with reinforcement of biosynthetic mesh|PROCEDURE: Incisional hernia repair with simple suture or synthetic mesh reinforcement.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Clinical and Serological Differences Among Juvenile, Adult, and Late-onset Systemic Lupus Erythematosus
Status: NOT_YET_RECRUITING
Conditions: Systemic Lupus Erythematosus (SLE)
Interventions: OTHER: clinical and serological differences among juvenile, adult, and late-onset systemic lupus erythematosus in a cohort of SLE patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety & Efficacy Study of the Medtronic CoreValve® System-Treatment of Symptomatic Severe Aortic Stenosis With Significant Comorbidities in Extreme Risk Subjects Who Need Aortic Valve Replacement
Status: ACTIVE_NOT_RECRUITING
Conditions: Severe Aortic Stenosis
Interventions: DEVICE: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p