pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Efficacy of Resticutis Compared to Platelet-Poor Plasma for Treating Diabetic Foot Ulcers
Status: UNKNOWN
Conditions: Diabetic Foot Ulcer
Interventions: OTHER: Resticutis|OTHER: Platelet-Poor Plasma (PPP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of Intravesical Apaziquone as a Surgical Adjuvant in Participant Undergoing Transurethral Resection Bladder Tumor (TURBT)
Status: TERMINATED
Conditions: Bladder Cancer
Interventions: DRUG: Apaziquone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intermittent and Maintenance of Icotinib in Combination With Pemetrexed/Carboplatin Compared With Icotinib Single Drug in Ⅲb/IV Non Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Mutation
Status: UNKNOWN
Conditions: Lung, Carcinoma
Interventions: DRUG: Icotinib,Pemetrexed,Carboplatin|DRUG: Icotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Sildenafil for Treatment of Urinary Incontinence
Status: ACTIVE_NOT_RECRUITING
Conditions: Urinary Incontinence
Interventions: DRUG: Sildenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pioglitazone and Rosiglitazone on Atherosclerotic and Inflammatory Markers in Patients With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DRUG: Pioglitazone, Rosiglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Multidomain Dietary Education in Type 2 Diabetic Adults
Status: COMPLETED
Conditions: Type2 Diabetes Mellitus|Cognitive Impairment, Mild
Interventions: BEHAVIORAL: cognitive stimulation|OTHER: as usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Erector Spinae Block and Pecto-Intercostal Facial Block For Enhanced Recovery in Adult Cardiac Surgery
Status: COMPLETED
Conditions: Cardiac Septal Defects With Coarctation of the Aorta|Mitral Regurgitation
Interventions: PROCEDURE: Ultrasound guided Pecto-intercostal- fascial plane block|PROCEDURE: Ultrasound guided erector spinae plane block|DRUG: Bupivacain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety and Pharmacokinetics of NP10679 in Normal Healthy Volunteers
Status: COMPLETED
Conditions: Safety Issues
Interventions: DRUG: Placebo|DRUG: NP10679
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: L-NMMA on GLP-2 Mediated Intestinal Lipoprotein Release
Status: COMPLETED
Conditions: Hyperlipidemias
Interventions: DRUG: Teduglutide + Normal Saline|DRUG: Teduglutide + L-NMMA|DRUG: Placebo + L-NMMA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Efficacy and Safety of (D/C/F/TAF) Once Daily Fixed Dose Combination (FDC) Regimen in Newly Diagnosed, Antiretroviral Treatment-naive Human Immunodeficiency Virus Type 1 (HIV-1) Infected Participants Receiving Care in a Test and Treat Model of Care
Status: COMPLETED
Conditions: HIV-1
Interventions: DRUG: DRV 800 mg + COBI 150 mg + FTC 200 mg + TAF 10 mg FDC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Randomized Trial of Adjuvant Chemotherapy With S-1 vs S-1/Oxaliplatin ± Radiotherapy for Completely Resected Gastric Adenocarcinoma : The ARTIST II Trial
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: TS-1, oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Mobile Application, Oncpatient, to Assist Patients Undergoing Radiation Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Internet-Based Intervention|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultrasound Enthesitis Response in Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis|Psoriasis|Enthesitis
Interventions: BIOLOGICAL: adalimumab|BIOLOGICAL: Certolizumab|BIOLOGICAL: Etanercept|BIOLOGICAL: Golimumab|BIOLOGICAL: Secukinumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Calibrated Diets and Human Intestinal Microflora
Status: COMPLETED
Conditions: Bacteria
Interventions: DIETARY_SUPPLEMENT: 10 g of fibres per day|DIETARY_SUPPLEMENT: 40 g of fibres per day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Open Label pH Comparison of Esomeprazole and Lansoprazole in Barrett's Esophagus Patients
Status: COMPLETED
Conditions: Barrett's Esophagus
Interventions: DRUG: Esomeprazole|DRUG: Lansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Acalabrutinib|DRUG: Venetoclax|DRUG: Chemoimmunotherapy|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BAX602 in Preventing the Adhesion Around Great Cardiac Vessels in Pediatric Patients With Congenital Heart Disease Undergoing Re-do Open Heart Surgery (Japan Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Congenital Heart Disease in Children
Interventions: DEVICE: BAX602|DEVICE: No Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: V-LAP™ Left Atrium Monitoring systEm for Patients With Chronic sysTOlic & Diastolic Congestive heaRt Failure
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure
Interventions: DEVICE: V-LAP™ System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A 3-month Study to Compare the Safety of ONS-5010 in Vials Versus Pre-filled Syringe in Subjects With Visual Impairment Due to Retinal Disorders
Status: ACTIVE_NOT_RECRUITING
Conditions: Age-Related Macular Degeneration|Neovascular Age-related Macular Degeneration|Wet Macular Degeneration|BRVO - Branch Retinal Vein Occlusion|Diabetic Macular Edema
Interventions: BIOLOGICAL: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single and Multiple Dose Safety, Tolerability, PK and Food Effect Study of HEC122505MsOH Tablets in Healthy Adult Subjects
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: HEC122505MsOH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrated Neuromuscular Inhibition Technique and Myofascial Release on Cervical Range of Motion and Dysfunction
Status: ENROLLING_BY_INVITATION
Conditions: Myofascial Trigger Point Pain
Interventions: DIAGNOSTIC_TEST: Integrated Neuromuscular Inhibition Technique|DIAGNOSTIC_TEST: Myofascial Release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Recovery Between NIVATS and Intubated Patients
Status: UNKNOWN
Conditions: Esophageal Function in Thoracoscopy
Interventions: DEVICE: endotracheal tube (double lumen)|DEVICE: nonintubated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Use of Lexiscan for Myocardial Stress Perfusion Computed Tomography With a 3rd Generation Dual Source CT System
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Artery Disease
Interventions: DRUG: Lexiscan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Trial of Zoledronic Acid in Patients With Myelofibrosis With Myeloid Metaplasia (MMM)
Status: COMPLETED
Conditions: Myelofibrosis|Myeloid Metaplasia
Interventions: DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of Single-dose Subcutaneous E6011 in Japanese Healthy Adult Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: E6011|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of MEMP1972A in Patients With Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: MEMP1972A|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Ulthera® System for the Treatment of Axillary Hyperhidrosis
Status: TERMINATED
Conditions: Primary Axillary Hyperhidrosis
Interventions: DEVICE: Ulthera System|DEVICE: Sham treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery
Status: COMPLETED
Conditions: Bleeding|Surgical Blood Loss
Interventions: DRUG: Tranexamic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PK Study of IV Formulation of GW856553
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DRUG: losmapimod 1 mg|DRUG: losmapimod|DRUG: losmapimod 15 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Move and Snooze: Adding Insomnia Treatment to an Exercise Program to Improve Pain Outcomes in Older Adults with Knee Osteoarthritis
Status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis|Insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spinal Infection Management With Structural Allograft
Status: COMPLETED
Conditions: Bone Diseases, Infectious|Disease of Bone|Syndrome|Spine Infection|Allografts|Bone Graft; Complications, Fracture
Interventions: DEVICE: Bone allograft|DEVICE: Bone auto and allograft group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Efficacy and Safety of Gemigliptin Compared With Placebo Added on Insulin Alone or on Insulin in Combination With Metformin in Type 2 DM (ZEUS II Study)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Gemigliptin|DRUG: Gemigliptin placebo|DRUG: Metformin|PROCEDURE: Diet/exercise questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RO6870810/TEN-010 in Participants With Acute Myeloid Leukemia and Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: RO6870810
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EF5 Prior to Surgery or Biopsy in Patients With Breast, Prostate, or Cervical Cancer or High Grade Soft Tissue Sarcoma
Status: TERMINATED
Conditions: Breast Cancer|Cervical Cancer|Head and Neck Cancer|Prostate Cancer|Sarcoma
Interventions: DRUG: EF5|OTHER: flow cytometry|OTHER: fluorescent antibody technique|OTHER: immunohistochemistry staining method|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Parker Flex-Tip Endotracheal Tube to Standard Endotracheal Tube
Status: COMPLETED
Conditions: Endotracheal Intubation
Interventions: DEVICE: FlexTip ETT (Parker FlexTip/GlideScope FlexTip)|DEVICE: Control - standard flexible ETT (Mallinckrodt)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the SCYX-7158
Status: COMPLETED
Conditions: Trypanosomiasis|Trypanosomiasis, African|Protozoan Infections|Parasitic Diseases
Interventions: DRUG: SCYX-7158|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of PRG-2311 for Refractory Lupus Nephritis and IgG4-Related Disease
Status: RECRUITING
Conditions: Lupus Nephritis|IgG4-related Disease
Interventions: BIOLOGICAL: PRG-2311
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Synchronised Auditory Stimulations of the Sleep Slow Oscillation on Deep Sleep Quality
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Stimulation of up-phase of sleep slow oscillation|DEVICE: Random stimulation of up phase of sleep slow oscillation|DEVICE: No stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility Study of Incorporating 18F-FDG-PET Imaging in Radiotherapy for Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Neoplasms
Interventions: PROCEDURE: FDG-PET-based dose escalation using intensity modulated radiation therapy (IMRT).
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Osteopathic Manipulative Treatment for Post-Operative Nausea and Vomiting
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: PROCEDURE: Osteopathic Manipulative Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Triage Administration of Ondansetron for Gastroenteritis in Children
Status: TERMINATED
Conditions: Gastroenteritis
Interventions: DRUG: Ondansetron|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laser Acupuncture Versus High Protein/Low Carbohydrate Diet on Endothelial Markers in Obese Females
Status: WITHDRAWN
Conditions: Obesity
Interventions: DEVICE: Laser acupuncture|BEHAVIORAL: high protein low carbohydrate diet|BEHAVIORAL: low caloric diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: BElumosudil for Bronchiolitis Obliterans Prevention/Therapy (BEBOP)
Status: RECRUITING
Conditions: Bronchiolitis Obliterans Syndrome|Bronchiolitis Obliterans|Lung Diseases|Chronic Graft Versus Host Disease
Interventions: DRUG: Belumosudil|DRUG: Fluticasone|DRUG: Azithromycin|DRUG: Prednisone|DRUG: Montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Niacin for Parkinsons Disease
Status: TERMINATED
Conditions: Parkinson's Disease
Interventions: DIETARY_SUPPLEMENT: Niacin|DIETARY_SUPPLEMENT: Niacinamide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (the RAINIER Study)
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: OC-02 (simpinicline) nasal spray|DRUG: Placebo (vehicle) nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II AZD9291 Open Label Study in NSCLC After Previous EGFR TKI Therapy in EGFR and T790M Mutation Positive Tumours
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: AZD9291
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Label, Single Dose, Three Part Study to Assess the Effects of Rolapitant (2 mg/mL IV Solution) on the Pharmacokinetics of Digoxin; Sulfasalazine; and the Cooperstown Cocktail (Midazolam, Omeprazole, Warfarin, Caffeine, and Dextromethorphan in Healthy Subjects
Status: COMPLETED
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: DRUG: Rolapitant|DRUG: Digoxin|DRUG: Sulfasalazine|DRUG: Cooperstown Cocktail
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pharmacokinetics and Tolerability Study of Fedratinib in Subjects With Moderate and Severe Hepatic Impairment
Status: COMPLETED
Conditions: Healthy Volunteers|Hepatic Impairment
Interventions: DRUG: Fedratinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of TDM-180935 in Atopic Dermatitis Patients
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: TDM-180935 topical ointment 1.0%|DRUG: TDM-180935 topical ointment 2.0%|DRUG: TDM-180935 topical vehicle ointment 1|DRUG: TDM-180935 topical vehicle ointment 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Myofascial Release on Dysphagia in Patients With Traumatic Brain Injury
Status: RECRUITING
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: Rehabilitation treatment|BEHAVIORAL: Myofascial Release Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Gait Retraining With Auditory Feedback
Status: COMPLETED
Conditions: Ankle Injuries|Ankle Inversion Sprain
Interventions: OTHER: Auditory Feedback|OTHER: No Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery
Status: RECRUITING
Conditions: Colorectal (Colon or Rectal) Cancer|Inflammation
Interventions: DRUG: Lidocaine IV|DRUG: Ketamine Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Inspired Helium for Ischemic Protection During Knee Replacement Surgery
Status: COMPLETED
Conditions: Ischemia
Interventions: PROCEDURE: Control Group|PROCEDURE: Single-Dose Heliox Group|PROCEDURE: Muscle Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Treatment With Fingolimod on the Immune Response Following Seasonal Flu Vaccination and Tetanus Booster Injection in Patients With Relapsing Multiple Sclerosis (MS)
Status: COMPLETED
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: Fingolimod|DRUG: Placebo|BIOLOGICAL: Seasonal influenza vaccine|BIOLOGICAL: Tetanus toxoid vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of Gleevec and Chlorambucil in Previously Treated Chronic Lymphocytic Leukemia Patients
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Gleevec and Chlorambucil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Validation of PolyDeep: an Artificial Intelligence-based Computer-aided Polyp Detection (CADe) and Characterization (CADx) System. Polydeep Advance 3
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: High definition colonoscopy (standard colonoscopy) in Adenoma Detection Rate|DIAGNOSTIC_TEST: PolyDeep assisted high definition colonoscopy (CAD system) in Adenoma Detection Rate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Preterm Infants' Paracetamol Study
Status: RECRUITING
Conditions: Persistent Ductus Arteriosus|Complication of Prematurity|Pain or Discomfort in Intensive Care of Preterm Infants
Interventions: DRUG: paracetamol|DRUG: 0.45 % saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Predictors of Non-invasive Respiratory Support Failure in COVID-19 Pneumonia
Status: COMPLETED
Conditions: Noninvasive Ventilation|Covid19|Distress; Respiratory Syndrome, Adult
Interventions: PROCEDURE: BiPAP|PROCEDURE: CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cabo-POLARIS : A Trial to Evaluate Cabozantinib Among Haemodialysied Patients
Status: NOT_YET_RECRUITING
Conditions: Cancer of Kidney
Interventions: DRUG: Cabozantinib|BIOLOGICAL: Blood sample|OTHER: Questionnaires of quality of life
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vascular Effects of a Single Bout of Electronic Cigarette Use
Status: COMPLETED
Conditions: Arterial Stiffness
Interventions: DRUG: E-cigarette|DRUG: Nicotine 0%|DRUG: Menthol Inhalant Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Hemostasis Evolution During Fluid Loading in Abdominal Surgery. Effects of Fluid Choice: Saline Versus Hydroxyethyl Starch (HAEMO Study)
Status: COMPLETED
Conditions: Postoperative Morbidity|Postoperative Mortality|Hemostasis Change
Interventions: BIOLOGICAL: 0.9% saline|BIOLOGICAL: HES 130/0.4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study to Evaluate the Evolution of Medication Satisfaction and Adherence in Patients Unsatisfied With Current Oral Atypical Antipsychotics by Switching Medication to Paliperidone Palmitate
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Paliperidone palmitate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Multiple Micronutrient Supplements in Reducing Anemia in Women of Reproductive Age
Status: ACTIVE_NOT_RECRUITING
Conditions: Anemia
Interventions: DIETARY_SUPPLEMENT: UNIMMAP-MMS|DIETARY_SUPPLEMENT: IFA|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Endpoint Study of Ivermectin 1% Cream
Status: COMPLETED
Conditions: Moderate to Severe Papulopustular Rosacea
Interventions: DRUG: Ivermectin Cream, 1%|DRUG: Placebo/Vehicle cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Angiotensin II Receptor Blockade in Vascular Ehlers Danlos Syndrome (ARCADE)
Status: COMPLETED
Conditions: Ehlers-Danlos Syndrome, Vascular Type
Interventions: DRUG: Irbesartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Sildenafil Citrate Used in Combination With Intravenous Epoprostenol in PAH
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Sildenafil citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Burst Optimized Stimulation Study
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DEVICE: Reprogramming of spinal cord stimulator (Proclaim or Prodigy SJM internal pulse generator) parameters according to study protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Tolerability and Efficacy Study of TU-100 For The Treatment of Postoperative Ileus
Status: COMPLETED
Conditions: Postoperative Ileus
Interventions: DRUG: Daikenchuto Extract Granules (TU-100)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Filgrastim in Treating Patients With Bortezomib-, Carfilzomib-, or IMID-Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Filgrastim|DRUG: Bortezomib|DRUG: Carfilzomib|DRUG: Dexamethasone|DRUG: Cyclophosphamide|DRUG: Thalidomide|DRUG: Lenalidomide|DRUG: Pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AB122 Platform Study
Status: RECRUITING
Conditions: Advanced or Metastatic Solid Tumor|Pancreatic Ductal Adenocarcinoma|Colorectal Cancer|Non-small Cell Lung Cancer|Gastric Cancer|Alveolar Soft Part Sarcoma
Interventions: DRUG: AB122|DRUG: AB122|DRUG: AB122|DRUG: TAS-116|DRUG: AB122|DRUG: TAS-116|DRUG: AB122|DRUG: TAS-116|DRUG: AB122|DRUG: TAS-120|DRUG: AB122|DRUG: TAS-115|DRUG: AB122|DRUG: TAS-115|DRUG: AB122|DRUG: TAS-102|DRUG: Ramucirumab|DRUG: AB122|DRUG: TAS-102|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Immunogenicity Study of GB002 Recombinant Peptide Inhalation Solution in Healthy Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DRUG: GB002 Recombinant Peptide Inhalation Solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PRE-VENT Study in Hospitalized Patients With Severe COVID-19 With or Without Cancer
Status: TERMINATED
Conditions: COVID19|COVID-19|COVID
Interventions: DRUG: Pacritinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Repeated Infusion of CELYVIR in Children and Adults With Metastatic and Refractory Tumors.
Status: COMPLETED
Conditions: Children|Solid Tumors|Metastases
Interventions: BIOLOGICAL: CELYVIR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Melatonin in the Effective Attainment of Sleep Electroencephalograms (EEG) in Children
Status: COMPLETED
Conditions: Epilepsy|Electroencephalogram|Children|Sedation
Interventions: DIETARY_SUPPLEMENT: Melatonin|DRUG: Chloral Hydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Self-collection for HPV Testing to Improve Cervical Cancer Prevention (SHIP) Trial
Status: RECRUITING
Conditions: Cervical Carcinoma|Human Papillomavirus Infection
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Cervical Biopsy|PROCEDURE: Colposcopy|PROCEDURE: Endocervical Curettage|PROCEDURE: Excision|PROCEDURE: HPV Self-Collection|PROCEDURE: Human Papillomavirus Test|OTHER: Questionnaire Administration|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ultra-Low Dose IL-2 Therapy as GVHD Prophylaxis in Haploidentical Allogeneic Stem Cell Transplantation
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia (ALL)|Acute Myelogenous Leukemia (AML)|Chronic Lymphocytic Leukemia (CLL)|Chronic Myelogenous Leukemia (CML)|MDS
Interventions: DEVICE: CliniMACS CD34 selection system|BIOLOGICAL: ULD IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Pharmacokinetics of Nicotinamide Mononucleotide (NMN) in Healthy Adults.
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Nicotinamide mononucleotide (NMN-C)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety Study of TRK-820 to Treat Conventional-treatment-resistant Pruritus in Patients Receiving Hemodialysis
Status: COMPLETED
Conditions: Conventional-treatment-resistant Pruritus in Patients Receiving Hemodialysis
Interventions: DRUG: nalfurafine hydrochloride (TRK-820)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Citrulline Challenge Study for Healthy Subjects in the United Kingdom
Status: COMPLETED
Conditions: Intestinal Diseases
Interventions: DIETARY_SUPPLEMENT: Amino Acid Supplement - One dose|DIETARY_SUPPLEMENT: 3-Methylhistidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Aripiprazole in Children and Adolescents With Bipolar I Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Aripiprazole|DRUG: Aripiprazole|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intermittent Oro-esophageal Tube vs Nasogastric Tube in Tracheostomized Patients With Intracerebral Hemorrhage
Status: TERMINATED
Conditions: Intracerebral Hemorrhage
Interventions: BEHAVIORAL: Basic treatment|BEHAVIORAL: comprehensive rehabilitation therapy|DEVICE: Intermittent Oro-esophageal Tube Feeding|DEVICE: Nasogastric Tube Feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bystander Helping Behaviour for Myocardial Infarction Following First Aid Training
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: OTHER: Helping behaviour curriculum|OTHER: First aid only curriculum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose:
Clinical trial: Feasibility and Efficacy of a Digital Mental Health Intervention for Teen Wildfire Survivors
Status: COMPLETED
Conditions: Disaster|PTSD|Adolescent Behavior|Trauma|Anxiety|Stress
Interventions: BEHAVIORAL: Sonoma Rises
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Safety and Tolerability Study of Cediranib (RECENTIN™, AZD2171) in Combination With Chemo in First Line Lung Cancer Patients
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: AZD2171|DRUG: Etoposide|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Dynamics of Oxytocin
Status: COMPLETED
Conditions: Brain Dynamics in Healthy Adults
Interventions: DRUG: Syntocinon Nasal Spray, 40IU|DRUG: Syntocinon Placebo Formulation, 40IU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Evaluation of the Safety and Efficacy of Methylone for the Treatment of PTSD
Status: RECRUITING
Conditions: Post Traumatic Stress Disorder
Interventions: DRUG: Methylone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Investigating the Safety of NNC 0113-0987 in Healthy Male Subjects
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2|Healthy
Interventions: DRUG: oral NNC 0113-0987|DRUG: oral NNC 0113-0987|DRUG: I.v. NNC 0113-0987|DRUG: oral placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ruxolitinib Versus Best Available Therapy in Patients With Corticosteroid-refractory Acute Graft vs. Host Disease After Allogeneic Stem Cell Transplantation
Status: COMPLETED
Conditions: Corticosteroid Refractory Acute Graft vs Host Disease
Interventions: DRUG: Ruxolitinib (RUX)|DRUG: Best Available Therapy (BAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib-based Regimen for Refractory or Relapsed Acute Lymphoblastic Leukemia
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia, in Relapse|Acute Lymphoblastic Leukemia With Failed Remission
Interventions: DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety/Tolerability After Oral Administration of CKD-387 and D635 in Healthy Adults
Status: UNKNOWN
Conditions: Type2 Diabetes Mellitus
Interventions: DRUG: CKD-387|DRUG: D635
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VItamiN D treatIng Chronic heArT Failure (the Effect of Vitamin D Supplementation in Patients With Heart Failure)
Status: NOT_YET_RECRUITING
Conditions: Chronic Heart Failure
Interventions: DIETARY_SUPPLEMENT: 4000IU Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Potlako: A Programmatic Intervention to Improve Access to Timely Oncology Care
Status: COMPLETED
Conditions: Neoplasms|HIV|Healthcare Disparity
Interventions: OTHER: Potlako intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Role of Combination Therapy in Women With Refractory Overactive Bladder
Status: NOT_YET_RECRUITING
Conditions: Overactive Bladder Syndrome
Interventions: DRUG: Vibegron 75mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Isotretinoin Versus Topical Tretinoin for Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Oral isotretinoin|DRUG: Tretinoin 0,05% cream|DRUG: Sunscreen FPS 60
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Effectiveness of Atorvastatin on the Progression of Aortic Dilatation and Valvular Degeneration in Patients With Bicuspid Aortic Valve
Status: COMPLETED
Conditions: Bicuspid Aortic Valve
Interventions: DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D Supplementation on Hemoglobin A1c in Patients With Uncontrolled Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Vitamin D3 2000 international units daily|DIETARY_SUPPLEMENT: Vitamin C 500mg daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Alisertib in Treating Patients With Recurrent or Persistent Leiomyosarcoma of the Uterus
Status: COMPLETED
Conditions: Recurrent Uterine Corpus Sarcoma|Uterine Corpus Leiomyosarcoma
Interventions: DRUG: Alisertib|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Emergency Physician-performed Ultrasound-guided Femoral Nerve Blocks in Patients With Hip Fractures.
Status: RECRUITING
Conditions: Hip Fractures
Interventions: PROCEDURE: ultrasound-guided femoral nerve block|DRUG: Intravenous or intramuscular pain medication
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iron Bioavailability From Dairy Product
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Dairy product fortified with enriched Fe-54 salt (1)|DIETARY_SUPPLEMENT: Dairy product fortified with enriched Fe-57 salt (2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Bioequivalence Study of an Acetylcysteine 2% Oral Solution Versus a Reference Fluimucil 2% Oral Solution
Status: COMPLETED
Conditions: Infections, Respiratory Tract
Interventions: DRUG: Fluimucil® 2% solution|DRUG: Acetylcysteine 2% solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Study of B001 Injection in Subjects With Neuromyelitis Optic Spectrum Disorder (NMOSD)
Status: RECRUITING
Conditions: NMO Spectrum Disorder
Interventions: DRUG: B001 injection|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Atezolizumab and Bevacizumab With SRF388 or Placebo in Patients With Hepatocellular Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: SRF388|DRUG: Atezolizumab|DRUG: Bevacizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CCL21-Gene Modified Dendritic Cell Vaccine and Pembrolizumab in Treating Patients With Stage IV Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Non-Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: BIOLOGICAL: Autologous Dendritic Cell-Adenovirus CCL21 Vaccine|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CDX-1401 in Patients With Malignancies Known to Express NY-ESO-1
Status: COMPLETED
Conditions: Advanced Malignancies
Interventions: BIOLOGICAL: CDX-1401 in combination with Resiquimod and/or Poly-ICLC|BIOLOGICAL: CDX-1401|BIOLOGICAL: Resiquimod|BIOLOGICAL: poly-ICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extracorporal Photopheresis With UVADEX Plus Standard Steroid Treatment for High Risk Acute Graft-versus-host Disease
Status: RECRUITING
Conditions: Acute-graft-versus-host Disease
Interventions: DRUG: Uvadex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ticagrelor in Remote Ischemic Preconditioning Study
Status: COMPLETED
Conditions: Periprocedural Myocardial Infarction
Interventions: DRUG: Ticagrelor|PROCEDURE: Remote Ischemic Preconditioning|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Trance, Hypnosis and Meditation in Oncology
Status: RECRUITING
Conditions: Cancer|Distress, Emotional|Pain|Fatigue|Sleep Disturbance|Cognitive Impairment
Interventions: BEHAVIORAL: Hypnosis group intervention|BEHAVIORAL: Cognitive trance group intervention|BEHAVIORAL: Meditation group intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Spatial Proteomics Profiles of Aldosterone-producing Adenoma and Unilateral Hyperplasia
Status: NOT_YET_RECRUITING
Conditions: Primary Aldosteronism Due to Aldosterone Producing Adenoma|Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
Interventions: DIAGNOSTIC_TEST: histopathology
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metabolic Effects of Enfuvirtide in Healthy Volunteers
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Enfuvirtide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Clinical Evaluation of Proclear Toric and Biofinity Toric
Status: ACTIVE_NOT_RECRUITING
Conditions: Astigmatism
Interventions: DEVICE: Lens A (omafilcon B)|DEVICE: Lens B (comfilcon A)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Three Methods Used in the Diagnosis of EER in Children With OME
Status: COMPLETED
Conditions: Otitis Media With Effusion|Laryngopharyngeal Reflux
Interventions: OTHER: Restech|OTHER: Peptest|OTHER: Detection of pepsin in adenoid specimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Periosteal Electrical Dry Needling for Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: periosteal electrical dry needling with no maintenance treatments|OTHER: periosteal electrical dry needling with maintenance treatments every other month|OTHER: periosteal electrical dry needling with monthly maintenance treatments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Quality of Life Improve in Multiple Sclerosis Patients Treated With Interferon Beta-1a?
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: Interferon beta-1a
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Safety of Tobramycin Inhalation Powder in Patients With Cystic Fibrosis
Status: COMPLETED
Conditions: Pulmonary Infections|Pseudomonas Aeruginosa in Cystic Fibrosis
Interventions: DRUG: TBM100
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tacrolimus/Everolimus Versus Tacrolimus/Enteric-Coated Mycophenolate Sodium
Status: COMPLETED
Conditions: Transplant; Failure, Kidney
Interventions: DRUG: Tacrolimus|DRUG: Everolimus|DRUG: Enteric Coated Mycophenolate Sodium (EC-MPS)|DRUG: Corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Activity in Children at Risk of Post-thrombotic Sequelae (PACT)
Status: COMPLETED
Conditions: Post Thrombotic Syndrome|Deep Vein Thrombosis
Interventions: DEVICE: Fitbit|BEHAVIORAL: 30-minute education session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Liposomal Irinotecan in Combination With Oxaliplatin and S-1 Versus Gemcitabine Combined With Capecitabine as Postoperative Adjuvant Therapy for Pancreatic Cancer
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Liposomal Irinotecan|DRUG: Oxaliplatin|DRUG: S-1|DRUG: Gemcitabine|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT