pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy of Adjunctive Low-Level Light Therapy to Intense Pulsed Light for Meibomian Gland Dysfunction
Status: NOT_YET_RECRUITING
Conditions: MGD-Meibomian Gland Dysfunction
Interventions: DEVICE: Low-level light therapy (LLLT)|DEVICE: Intense pulsed light (IPL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Contrave for Weight Maintenance in Adults With BMI >= 27 Kg/m2, After 6 Month Behaviour Modification Program.
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: DRUG: Contrave 8Mg-90Mg Extended-Release Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Immunogenicity of a Sublingual Influenza Vaccine NSV0001 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: NSV0001|BIOLOGICAL: Influenza HA vaccine "Biken HA"|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Multicenter, Open-Label, Non-Inferiority Randomized Controlled Trial of Postoperative VTE Prevention in Chinese Patients After Colorectal Cancer Surgery
Status: NOT_YET_RECRUITING
Conditions: Colorectal Surgery|VTE (Venous Thromboembolism)
Interventions: DRUG: Low Molecular Weight Heparin (dalteparin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of CVN424 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CVN424|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Safety and Tolerability of Intravenous Brivaracetam (BRV) as Replacement for Oral Brivaracetam in Japanese Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization
Status: COMPLETED
Conditions: Partial Seizures With or Without Secondary Generalization|Epilepsy
Interventions: DRUG: Brivaracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Transformation of Locally Advanced Pancreatic Cancer.
Status: UNKNOWN
Conditions: Locally Advanced Pancreatic Cancer
Interventions: DRUG: carleilizumab+apathy mesylate+radiotherapy+paclitaxel (albumin-bound)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Effect of Pembrolizumab (MK-3475) in Participants With Renal Cell Cancer (MK-3475-031)
Status: TERMINATED
Conditions: Renal Cell Cancer
Interventions: DRUG: Pembrolizumab Pre-Resection|PROCEDURE: Surgical Resection|DRUG: Pembrolizumab Post-Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of LINAGLIPTIN on Inflammation, Oxidative Stress and Insulin Resistance in Obese Type 2 Diabetes Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Linagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Folfox6 + Cetuximab Versus Folfiri +Cetuximab in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Cetuximab, Oxaliplatin, Leucovorin, 5FU, Irinotecan|DRUG: FOLFOX 6|DRUG: FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin Plus Modified FOLFOX 6 in Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Acinar Cell Adenocarcinoma of the Pancreas|Duct Cell Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer
Interventions: DRUG: metformin hydrochloride|DRUG: oxaliplatin|DRUG: leucovorin calcium|DRUG: fluorouracil|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Response Assessment of Induction Chemotherapy in Acute Myeloid Leukemia Patients Using F-18 FLT PET/CT
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: OTHER: FLT PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Oral Fampridine-SR in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Fampridine-SR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Oxaliplatin-induced Nerve Damage in the Body's Extremities
Status: RECRUITING
Conditions: Peripheral Neuropathy|Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: Fish oil|DIETARY_SUPPLEMENT: Corn oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Evaluating the Safety, Tolerability, and Initial Efficacy of Recombinant Human Anti-T-cell Immunoreceptor With Ig and ITIM Domains (TIGIT) Monoclonal Antibody Injection (IBI939) in Subjects With Advanced Malignant Tumors
Status: COMPLETED
Conditions: Advanced Malignancies
Interventions: DRUG: IBI939|DRUG: IBI939+ Sintilimab|DRUG: IBI939+ Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transarterial Infusion of PD-1 Antibody Plus TACE-HAIC for Unresectable HCC: a Single-arm, Phase 2 Clinical Trial
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: PD-1 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Degree of Head Elevation on Insertion Success for ProSeal Laryngeal Mask Airway Insertion
Status: COMPLETED
Conditions: Anesthesia
Interventions: DEVICE: Insertion of ProSeal laryngeal mask airway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: School-based HIIT and Dose-Response Effects
Status: ACTIVE_NOT_RECRUITING
Conditions: Adolescents|Physical Activity|Adipose Tissue|Blood Pressure|Cardiorespiratory Fitness
Interventions: BEHAVIORAL: standard high-intensity interval training|BEHAVIORAL: plyometric high-intensity interval training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Dose Ketamine as an Adjunct to Opiates for Acute Pain in the Emergency Department
Status: COMPLETED
Conditions: Acute Pain|Pain
Interventions: DRUG: Ketamine|DRUG: Normal Saline|DRUG: opiate analgesic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patch Test Skin Irritation/Sensitization of Cetaphil Daily Advance Ultra Hydration Lotion
Status: COMPLETED
Conditions: Determine Sensitivity of Skin to Cetaphil Daily Advance Ultra Hydrating Lotion
Interventions: OTHER: Cetaphil Daily Advance Ultra Hydrating Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Success Rate of Pulpal Anesthesia in Mandibular First Molar Following Infiltration of 4% Articaine Alone and as Supplemental Injection After Inferior Alveolar Nerve Block
Status: COMPLETED
Conditions: Pulpal Anesthesia
Interventions: OTHER: Lidocaine(IANB)|OTHER: 1 Articaine(Infiltration)|OTHER: 2 Articaine(Infiltration)|OTHER: Lidocaine(IANB)+1Articaine(Infiltration)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Pharmacology Study of K-877 Controlled Release Tablet
Status: COMPLETED
Conditions: Dyslipidemias
Interventions: DRUG: K-877 IR 0.2 mg/day|DRUG: K-877 CR 0.4 mg/day|DRUG: K-877 CR 0.8 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Perioperative Hemodynamic Optimization on the Immune Function Parameters of Peripheral Blood Monocytes After Cardiac Surgery
Status: UNKNOWN
Conditions: Postoperative Wound Infection|Postoperative Outcome
Interventions: DEVICE: Pulse contour cardiac output device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Coaches of Older Adults for Cancer Care and Health Behaviors
Status: COMPLETED
Conditions: Colorectal Cancer|Breast Cancer|Cervical Cancer
Interventions: BEHAVIORAL: Coach Training (COACH)|BEHAVIORAL: Printed Educational Materials (PEM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients With Septic Shock (VBI-S-02)
Status: RECRUITING
Conditions: Septic Shock|Sepsis|Hypovolemia
Interventions: DRUG: VBI-S
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Weak Extremely Low Frequency Electromagnetic Fields in Mild and Moderate Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DEVICE: Magnetic field generator|DEVICE: Placebo magnetic field generator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Pilot Study of ACTH in the Treatment of Immunoglobulin A (IgA) Nephropathy at High Risk of Progression
Status: COMPLETED
Conditions: Progressive IgA Nephropathy|Proteinuria
Interventions: DRUG: ACTH (Acthar) Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Tocotrienols on Insulin Sensitivity and Metabolic Risk Markers in Individuals at Risk for Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Gamma delta TRF|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Diabetes Closed-Loop Project 6 (DCLP6): Fully Automated Closed-Loop Control in Type 1 Diabetes Using Meal Anticipation
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: Fully Closed Loop (FCL)|DEVICE: Fully Closed Loop with meal anticipation module (FCL+)|DEVICE: Hybrid Closed Loop (HCL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ledipasvir/Sofosbuvir Fixed-Dose Combination + Ribavirin in Subjects With Chronic HCV With Advanced Liver Disease or Post-Liver Transplant
Status: COMPLETED
Conditions: Chronic HCV Infection
Interventions: DRUG: LDV/SOF|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Trial of Tele-IPT and Tele-Pharmacotherapy for Patients With Depression and Non-Metastatic Breast Cancer
Status: RECRUITING
Conditions: Major Depressive Disorder|Breast Cancer|Venlafaxine
Interventions: BEHAVIORAL: Interpersonal Psychotherapy|DRUG: Venlafaxine HCl ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pregabalin for Opiate Withdrawal Syndrome
Status: COMPLETED
Conditions: Opioid Withdrawal
Interventions: DRUG: Pregabalin|DRUG: Clonidine|DRUG: Doxylamin|DRUG: Ketorolac, Loperamide, Metoclopramide, Nefazolin and Phenazepam (benzodiazepine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intracranial Stenting in Non-acute Symptomatic Ischemic Stroke
Status: UNKNOWN
Conditions: Intracranial Arteriosclerosis|Ischemic Stroke|Intracranial Arterial Diseases|Arterial Occlusive Diseases
Interventions: PROCEDURE: Medical treatment plus intracranial stenting|DRUG: Medical treatment alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Program to Improve Statin Adherence and Lower Cholesterol in Older Adults
Status: COMPLETED
Conditions: Hypercholesterolemia|Medication Adherence
Interventions: BEHAVIORAL: Medication adherence intervention|BEHAVIORAL: Attention-control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety, Tolerability and Pharmacokinetic Profile of PBF -509 (80 mg, 160 mg and 240 mg) "After Multiple Oral Doses" in Healthy Volunteers
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: PBF-509|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Benefits of Exergames on Neurocognitive Functions in Adults Suffering From Depression
Status: NOT_YET_RECRUITING
Conditions: Depression
Interventions: BEHAVIORAL: Exergame-Based Training|BEHAVIORAL: Cognitive-Based Training|BEHAVIORAL: Wait-List
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treatment for Patients With Gynecological Malignancies Who Suffer From Anemia Due to Chemotherapy
Status: COMPLETED
Conditions: Gynecological Malignancies|Genital Neoplasms, Female|Anemia
Interventions: DRUG: darbepoetin alfa|DRUG: recombinant human erythropoietin (rHuEPO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Bendamustine, Bortezomib, and Rituximab in Patients With Previously Untreated Low Grade Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Bendamustine|DRUG: Bortezomib|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short-Term Anti-plaque Effect of Cymenol Mouthwash Analysed Using Dentius Deep Plaque Software
Status: COMPLETED
Conditions: Healthy|Dental Plaque
Interventions: DRUG: Placebo Mouthwash|DRUG: Cymenol mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Effect of Multiple Doses of LOXO-305 on the Pharmacokinetics of Single Oral Doses of CYP1A2, CYP2C9, CYP2C19 Substrates in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Caffeine Tablet|DRUG: Omeprazole capsule|DRUG: Warfarin tablet|DRUG: LOXO-305
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Changes in Habitual Physical Activity and Inactivity
Status: COMPLETED
Conditions: Habitual Physical Activity|Sedentary Time
Interventions: BEHAVIORAL: exercise training|BEHAVIORAL: sedentary time reduction|BEHAVIORAL: exercsie training plus sedentary time reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Para-Tyrosine Supplementation on the Survival and Clinical Outcome in Patients With Sepsis
Status: NOT_YET_RECRUITING
Conditions: Sepsis
Interventions: DRUG: Para-Tyrosine supplementation|DRUG: Placebo solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Exploring the Potential of Novel Biomarkers Based on Plasma microRNAs for a Better Management of Pelvic Gynecologic Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer|Endometrial Cancer
Interventions: OTHER: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Daily Monitoring of Respiratory Symptoms and Spirometry During ETI Treatment in Persons With Cystic Fibrosis.
Status: ACTIVE_NOT_RECRUITING
Conditions: Cystic Fibrosis
Interventions: DRUG: Elexacaftor 100 MG / Ivacaftor 75 MG / Tezacaftor 50 MG, 2 tablets each morning + Ivacaftor 150 mg one tablet each evening
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MRD Guided De-intensification of Bendamustine/Rituximab for Indolent Non-Hodgkin Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Lymphoma|Indolent Non-hodgkin Lymphoma
Interventions: DRUG: Bendamustine|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: FFP3 Respirators and Ears - Effects on Middle Ear Pressure and Hearing
Status: UNKNOWN
Conditions: Eustachian Tube Dysfunction|Hearing Disorders|Nasal Obstruction
Interventions: OTHER: FFP3 Mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment for Problematic Sexual Behavior of Preteen Children
Status: RECRUITING
Conditions: Problematic Sexual Behavior Among Preteen Children
Interventions: BEHAVIORAL: Phase-based Treatment (PBT) for Problematic Sexual Behavior of Preteen Children|BEHAVIORAL: Treatment-as-Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chidamide Combination With Lenalidomide in Patients With Relapsed or Refractory Peripheral T-cell Lymphoma
Status: RECRUITING
Conditions: Relapsed or Refractory Peripheral T-cell Lymphoma
Interventions: DRUG: Chidamide, Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smoking Cessation for Low-Income Pregnant Women
Status: COMPLETED
Conditions: Pregnancy|Smoking
Interventions: BEHAVIORAL: Cognitive-Behavioral Counseling (CBC)|BEHAVIORAL: Best Practice (BC) Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Narrowband UVB Phototherapy on Systemic Inflammation in Patients With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: OTHER: Narrow band UVB treatment (NB-UVB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multi-level Molecular Profiling of Stress Exposure Under Standardized Food Intake: A Clinical Study
Status: RECRUITING
Conditions: Stress Related Disorder|Nutrition, Healthy|Metabolism
Interventions: BEHAVIORAL: Sleep Deprivation|DRUG: Dexamethasone Supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Sintilimab Combined With Regorafenib and Cetuximab / Sintilimab Combined With Regorafenib in Posterior Line Therapy of Advanced Colorectal Cancer (Regosinti)
Status: RECRUITING
Conditions: Sintilimab, Cetuximab, Regorafenib,Combine,mCRC
Interventions: DRUG: Sintilimab，regofinib，cetuximab|DRUG: KRAS BRAF mutant Sintilimab + regafinil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Citalopram and Self Emotional Processing
Status: UNKNOWN
Conditions: Molecular Mechanisms of Pharmacological Action|Depression|Depressive Disorder|Mental Disorder|Antidepressive Agents|Cognition
Interventions: DRUG: Citalopram|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Solid Tumor|Tumors of Any Histology With Activating Trk (NTRK) Point or NTRK Fusion Mutations|Tenosynovial Giant Cell Tumor
Interventions: DRUG: PLX7486 TsOH
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemiarthroplasty or Internal Fixation for Displaced Femoral Neck Fractures
Status: COMPLETED
Conditions: Femoral Neck Fractures
Interventions: PROCEDURE: Bipolar hemiarthroplasty (Charnley/Hastings)|PROCEDURE: Internal fixation with two parallel screws (Olmed)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Medication Development in Alcoholism: Acamprosate Versus Naltrexone
Status: COMPLETED
Conditions: Alcoholism
Interventions: DRUG: Acamprosate|DRUG: Naltrexone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Bevacizumab in Pats w/ Recurrent ST Brain Metas Who Have Failed Whole Brain Radiation Therapy
Status: COMPLETED
Conditions: Metastatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: bevacizumab|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estradiol in Treating Patients With ER Beta Positive, Triple Negative Locally Advanced or Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Triple-Negative Breast Carcinoma|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Triple-Negative Breast Carcinoma|Recurrent Breast Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|BIOLOGICAL: Therapeutic Estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalise Antidepressant Treatment for Unipolar Depression Combining Individual Choices, Risks and Big Data
Status: NOT_YET_RECRUITING
Conditions: Depression
Interventions: OTHER: PETRUSHKA tool|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Ketamine for Anxiolysis in Pediatric Emergency Department Patients
Status: TERMINATED
Conditions: Anxiety|Pediatric ALL|Procedural Anxiety
Interventions: DRUG: Ketamine 100 MG/ML|DRUG: Midazolam 5 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Muscle Activity of Children With Spastic Unilat Cerebral Palsy Using 2 Types of Ankle-foot Orthoses to Walk
Status: UNKNOWN
Conditions: Cerebral Palsy, Spastic|Hemiplegic Cerebral Palsy
Interventions: DEVICE: Ankle-foot orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Talazoparib With Androgen Deprivation Therapy and Abiraterone for the Treatment of Castration Sensitive Prostate Cancer
Status: RECRUITING
Conditions: Castration-Sensitive Prostate Carcinoma|Metastatic Prostate Adenocarcinoma|Stage IV Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8|Stage IVB Prostate Cancer AJCC v8
Interventions: DRUG: Abiraterone Acetate|DRUG: Bicalutamide|DRUG: Degarelix|DRUG: Goserelin Acetate|DRUG: Leuprolide Acetate|DRUG: Prednisone|OTHER: Questionnaire Administration|DRUG: Talazoparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Efficacy and Safety of Brolucizumab Versus Aflibercept in Patients With Visual Impairment Due to Macular Edema Secondary to Branch Retinal Vein Occlusion
Status: TERMINATED
Conditions: Branch Retinal Vein Occlusion
Interventions: DRUG: Brolucizumab 6 mg|DRUG: Aflibercept 2 mg|OTHER: Sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Extension to Bridging Study CTBM100C2303
Status: COMPLETED
Conditions: Pseudomonas Aeruginosa|Cystic Fibrosis
Interventions: DRUG: Tobramycin inhalation powder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab Alone or Plus Relatlimab or Ipilimumab for Patients With Locally-Advanced Unresectable or Metastatic Basal Cell Carcinoma
Status: RECRUITING
Conditions: Basal Cell Carcinoma
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab|DRUG: Relatlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Convalescent Plasma Therapy for Hospitalized Patients With COVID-19
Status: COMPLETED
Conditions: COVID-19|Convalescent Plasma|SARS-CoV-2|Pneumonia|Coronavirus Infections|Respiratory Tract Diseases
Interventions: BIOLOGICAL: Convalescent plasma|DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Image-guided and Intensity-modulated Radiotherapy Versus External Beam Radiotherapy for Patients With Spine Metastases
Status: UNKNOWN
Conditions: Vertebral Bony Metastases
Interventions: RADIATION: IMRT|RADIATION: fractionated RT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy and Pembrolizumab in Treating Patients With Localized Urothelial Bladder Cancer
Status: WITHDRAWN
Conditions: Infiltrating Bladder Urothelial Carcinoma|Stage II Bladder Urothelial Carcinoma AJCC v6 and v7|Stage III Bladder Urothelial Carcinoma AJCC v6 and v7
Interventions: RADIATION: Hypofractionated Radiation Therapy|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotics Strains for Infant Colic
Status: RECRUITING
Conditions: Colic
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Limosilactobacillus reuteri CCT 7862|DIETARY_SUPPLEMENT: Bifidobacterium lactis CCT 7858 + Lactobacillus rhamnosus CCT 7863
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Single-strain Probiotics in Patients With Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Probiotic Bifidobacterium lactis|DIETARY_SUPPLEMENT: Probiotic Bacillus coagulans|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Contribution of Hypnosis in the Tolerance of the Bronchoscopy
Status: ACTIVE_NOT_RECRUITING
Conditions: Respiratory System Abnormalities
Interventions: PROCEDURE: hypnosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Lazertinib+Pemetrexed/Carboplatin in Patients With EGFR Sensitizing Mutation Positive Recurrent or Metastatic Non-Small Cell Lung Cancer Failed to Prior Lazertinib
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Lazertinib/Pemetrexed/Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Buffered Lidocaine With Epinephrine in Local Anesthesia
Status: COMPLETED
Conditions: Pain|Anesthesia, Local
Interventions: PROCEDURE: lidocaine with epinephrine|PROCEDURE: sodium bicarbonate|PROCEDURE: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Regulation of Inflammatory Parameters by Telmisartan in Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension|Metabolic Syndrome|Hypertriglyceridemia
Interventions: DRUG: telmisartan|DRUG: telmisartan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Atrial Fibrillation Recurrence After Cryoballoon Ablation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: OTHER: Use of the Achieve catheter followed by ICE-guided mapping catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: RetinaVue Diabetic Screening
Status: UNKNOWN
Conditions: Diabetic Retinopathy
Interventions: DIAGNOSTIC_TEST: Non-mydriatic color fundus photography with the RetinaVue camera|DIAGNOSTIC_TEST: Referral for dilated eye exam with an eye care professional
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Pilot Evaluation of the Cynosure Potenza™ System for Treatment of Cosmetic Dermatologic Skin Conditions
Status: RECRUITING
Conditions: Wrinkles|Scars|Stretch Marks|Pigmentation|Skin Laxity
Interventions: DEVICE: Potenza|DEVICE: Icon
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study to Assess AMI Treated With Balloon Angioplasty.
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: drug-eluting stent|DEVICE: bare-metal stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Soluble Programmed Death 1 (sPD1) is a Diagnostic Biomarker of ILD in Patients With Rheumatoid Arthritis Disease
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DIAGNOSTIC_TEST: soluble programmed death 1biomarker
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Pharmacokinetics, Safety, and Tolerability of TPM XR as Adjunctive Therapy in Pediatric Subjects With Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: TPM XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Assessing Change in Sense of Smell After Rasagiline Use in Parkinson's Patients
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: DRUG: Rasagiline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Plant Protein Amino Acids
Status: COMPLETED
Conditions: Bioavailability of Amino Acids Following Oral Ingestion of Plant-Based Proteins in Young, Healthy Men
Interventions: DIETARY_SUPPLEMENT: Pea-protein concentrate|DIETARY_SUPPLEMENT: Fava-bean protein concentrate|DIETARY_SUPPLEMENT: Chickpea protein concentrate|DIETARY_SUPPLEMENT: Red lentil protein concentrate|DIETARY_SUPPLEMENT: Non-essential amino acid blend|DIETARY_SUPPLEMENT: Whey protein concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of Anti-BCMA/GPRC5D CAR-T Cell Therapy in Treating Relapsed and Refractory Multiple Myeloma(rr/MM)
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: OTHER: anti-BCMA/GPRC5D CAR-T CELL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MEDI-522 in the Treatment of Patients With Metastatic Androgen-Independent Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: MEDI-522|BIOLOGICAL: Docetaxel + Prednisone* + Zoledronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Absorption, Distribution, Metabolism and Excretion of [14C] Labelled BIA 5-1058
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DRUG: 400 mg of BIA 5-1058
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation Effects on Nicotine Craving
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: DEVICE: Transcranial Magnetic Stimulation (Neuronetics)|DEVICE: Sham Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Effect of Atorvastatin on the Pharmacokinetic Properties of Telmisartan/S-amlodipine
Status: COMPLETED
Conditions: Essential Hypertension|Hyperlipidemia
Interventions: DRUG: Telmisartan 80mg, S-amlodipine 5mg and Atorvastatin 40mg|DRUG: Telmisartan 80mg and S-amlodipine 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Achilles Tendinopathy Treated With Training and Injections
Status: COMPLETED
Conditions: Achilles Tendinopathy
Interventions: BEHAVIORAL: Reduction in running and jumping|OTHER: Training|DRUG: Ultrasound guided injection with Glucocorticosteroid|DRUG: Ultrasound guided injection with local anaestethic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of Vildagliptin on the Insulin Response to Glucose in Subjects With Pre-diabetes
Status: COMPLETED
Conditions: Pre-diabetes
Interventions: DRUG: Vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: DiamondTemp™ Ablation System for the Treatment of Paroxysmal Atrial Fibrillation
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation|Atrial Fibrillation
Interventions: DEVICE: DiamondTemp Ablation catheter|DEVICE: TactiCath Quartz Ablation catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tranexamic Acid on Postoperative Bleeding Following Sinus and Nasal Surgery
Status: COMPLETED
Conditions: Chronic Sinusitis|Nasal Obstruction|Turbinate; Hypertrophy Mucous Membrane|Deviated Nasal Septum - Congenital|Deviated Nasal Septum Acquired
Interventions: DRUG: Tranexamic Acid 1,000 Mg/10 mL (100 Mg/mL) INTRAVEN VIAL (ML)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neo-adjuvant T-VEC + Nivolumab Combination Therapy for Resectable Early Metastatic (Stage IIIB/C/D-IV M1a) Melanoma With Injectable Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma Stage III|Melanoma Stage IV
Interventions: DRUG: T-VEC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sensory Stimulation During CIMT
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: BEHAVIORAL: Standardized Constraint-Induced Movement Therapy|BEHAVIORAL: Vibration|BEHAVIORAL: Placebo (for vibration)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Investigation Detecting Cryoablation Scar by 3D Late Gadolinium Enhancement
Status: COMPLETED
Conditions: Atrial Fibrillation|Cryoablation
Interventions: PROCEDURE: Pulse Sequence|PROCEDURE: CMRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ruxolitinib + Allogeneic Stem Cell Transplantation in AML
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Acute Myeloid Leukemia in Remission|Allogeneic Stem Cell Transplantation
Interventions: DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of NXL103 Versus Linezolid in Adults With Acute Bacterial Skin and Skin Structure Infections (ABSSSI)
Status: COMPLETED
Conditions: Acute Bacterial Skin and Skin Structure Infections
Interventions: DRUG: NXL103|DRUG: Linezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Diagnosis of Invasive Depth of Early Rectal Cancer
Status: UNKNOWN
Conditions: Early Rectal Cancer
Interventions: DIAGNOSTIC_TEST: Linear EUS first|DIAGNOSTIC_TEST: ME-NBI first
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Three-month, Single-center Study to Identify Biomarkers/Response to Xolair Therapy in Chronic Idiopathic Urticaria
Status: COMPLETED
Conditions: Chronic Idiopathic Urticaria
Interventions: BIOLOGICAL: Xolair
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder|Alcohol Use Disorder
Interventions: DRUG: Ketamine + Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Effect of Energy Alignment and Mantra on Stress Related Pain in Adolescents
Status: COMPLETED
Conditions: Stress Related Disorder|Musculoskeletal Pain|Headache
Interventions: BEHAVIORAL: Yoga based Energy Alignment and Mantra
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pre-Post Study for Supporting Appropriate Implementation of Lung Cancer Screening
Status: COMPLETED
Conditions: Lung Neoplasms|Early Detection of Cancer|Decision Support Techniques|Primary Health Care
Interventions: BEHAVIORAL: Pre/Post Test of a Lung Cancer Screening Decision Aid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Vicriviroc (SCH 417690) in Combination Treatment With Optimized ART Regimen in Experienced Participants (VICTOR-E1) (MK-7690-020/P03672)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Vicriviroc 30 mg|DRUG: Vicriviroc 20 mg|DRUG: Placebo|DRUG: Placebo|DRUG: Background ART Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of 2D and 3D Imaging Modalities and Its Influence on Diagnosis and Treatment Planning in Orthodontics
Status: COMPLETED
Conditions: Orthodontics|Malocclusion|Impacted Tooth|Cephalometry|Cone-Beam Computed Tomography|Panoramic Radiography
Interventions: RADIATION: Panoramic radiograph, Cephalometric radiograph|RADIATION: Cone-beam computed tomography (CBCT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Trial of Microsphere Oxycodone (Xtampza ER) for Pain Management in Patients Receiving Radiotherapy for Locally Advanced Head and Neck Cancer
Status: COMPLETED
Conditions: Locally Advanced Head and Neck Cancer
Interventions: DRUG: Xtampza ER
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC)
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: BIOLOGICAL: Ipilimumab|DRUG: Oxaliplatin|DRUG: Leucovorin|DRUG: Fluorouracil|DRUG: Irinotecan|DRUG: Bevacizumab|DRUG: Cetuximab|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Intensity Stem Cell Transplantation for Chronic Lymphocytic Leukemia Followed by Vaccination
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: GM-K562 vaccine|PROCEDURE: stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cocaine and Zolmitriptan
Status: RECRUITING
Conditions: Cocaine Use Disorder
Interventions: DRUG: Cocaine|DRUG: Placebo oral capsule|DRUG: Zolmitriptan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Exparel to Marcaine in Post-Surgical Analgesia in Bariatrics
Status: WITHDRAWN
Conditions: Post Operative Pain
Interventions: PROCEDURE: Laparoscopic Roux en Y gastric bypass|PROCEDURE: Laparoscopic Sleeve Gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Topical Lidocaine on Pain Scores During Manual Vacuum Aspiration for Nonviable Pregnancies
Status: COMPLETED
Conditions: Nonviable Pregnancy
Interventions: DRUG: Lidocaine|DRUG: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Monitoring During Different Intermittent Fasting Protocols in Non-Obese Adults
Status: COMPLETED
Conditions: Intermittent Fasting|Overweight|Time Restricted Feeding
Interventions: BEHAVIORAL: Time-Restricted Feeding|BEHAVIORAL: Alternate Day Fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial of a Personalized and Adaptive Neoantigen Dose-Adjusted Vaccine Concurrently With Pembrolizumab
Status: NOT_YET_RECRUITING
Conditions: Squamous Cell Lung Cancer|Squamous Non-small Cell Lung Cancer|Squamous Cell Carcinoma of Head and Neck
Interventions: BIOLOGICAL: PANDA-VAC|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Programmed Death Ligand 1 (PDL1) Response to Treatment in Patient-derived Organoids and Immune-marker Positron Emission Tomography (PET) Scanning in Non-small Cell Lung Cancer (NSCLC)
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer, Non-Small Cell
Interventions: BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Dostarlimab|DRUG: Pemetrexed+ (carboplatin or cisplatin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study to Evaluate Ranger DEB for BTK Angioplasty in Patients With CLI (RANGER-BTK)
Status: UNKNOWN
Conditions: Lower Limb Ischemia|Peripheral Vascular Diseases
Interventions: DEVICE: Ranger SL DEB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression
Status: NOT_YET_RECRUITING
Conditions: Treatment Resistant Depression
Interventions: DRUG: VLS-01-203 BU|DRUG: VLS-01-BU Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab and Trastuzumab-MCC-DM1 Administered Intravenously and GDC-0941 Administered Orally to Patients With HER2-Positive Metastatic Breast Cancer Who Have Progressed on Previous Trastuzumab-Based Therapy
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: GDC-0941|DRUG: Trastuzumab|DRUG: trastuzumab-MCC-DM1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT