pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pembrolizumab, Radiotherapy, and Chemotherapy in Neoadjuvant Treatment of Malignant Esophago-gastric Diseases (PROCEED)
Status: COMPLETED
Conditions: Locally Advanced Esophageal and Gastric Cancers (EGC)
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I-II Study of Interferon-gamma in Patients With HER-2 Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Breast Cancer, Male|Breast Cancer Female|HER2-positive Breast Cancer
Interventions: BIOLOGICAL: Interferon-gamma (IFN-γ)|DRUG: Paclitaxel|DRUG: Trastuzumab|OTHER: Pertuzumab|PROCEDURE: Post Therapy Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Formulation for Sleep Among People With Poor Sleep Quality
Status: COMPLETED
Conditions: Sleep|Sleep Disorder|Insomnia|Quality of Life|Poor Quality Sleep
Interventions: DIETARY_SUPPLEMENT: Supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-inflammatory Effect of Low-Dose Whole-Lung Radiation for COVID-19 Pneumonia
Status: COMPLETED
Conditions: COVID-19 Pneumonia
Interventions: RADIATION: Low Dose Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Manual Dexterity Modifications After Application of tSMS Over the Primary Motor Cortex (M1)
Status: UNKNOWN
Conditions: Stroke|Neurologic Disorder|Manual Dexterity
Interventions: DEVICE: tSMS|DEVICE: Sham tSMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: ABC-Scores for Reduction of Stroke and Mortality in Atrial Fibrillation - The ABC-AF Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: OTHER: ABC score guided therapy|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of VX-659 Combination Therapy in CF Subjects Homozygous for F508del (F/F)
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: VX-659/TEZ/IVA|DRUG: TEZ/IVA|DRUG: IVA|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gradual Egg-tolerance Induction in Hen's Egg Allergic Children Who Tolerate Baked Egg (TETI-II Study)
Status: ACTIVE_NOT_RECRUITING
Conditions: Egg Hypersensitivity
Interventions: BEHAVIORAL: assigned period of specific dietary restrictions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukodystrophy|White Matter Disease|4H Syndrome|Adrenoleukodystrophy|AMN|ALD|ALD (Adrenoleukodystrophy)|X-linked Adrenoleukodystrophy|X-ALD|Adrenomyeloneuropathy|Aicardi Goutieres Syndrome|AGS|Alexander Disease|Alexanders Leukodystrophy|AxD|ADLD|Canavan Disease|CTX|Cerebrotendinous Xanthomatoses|Krabbe Disease|GALC Deficiency|Globoid Leukodystrophy|TUBB4A-Related Leukodystrophy|H-ABC - Hypomyelination, Atrophy of Basal Ganglia and Cerebellum|HBSL|HBSL - Hypomyelination, Brain Stem, Spinal Cord, Leg Spasticity|LBSL|Leukoencephalopathy With Brain Stem and Spinal Cord Involvement and High Lactate Syndrome (Disorder)|Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation|ALSP|CSF1R Gene Mutation|HCC - Hypomyelination and Congenital Cataract|MLC1|Megalencephalic Leukoencephalopathy With Subcortical Cysts 1|MLD|Metachromatic Leukodystrophy|PMD|Pelizaeus-Merzbacher Disease|PLP1 Null Syndrome|PLP1 Gene Duplication &#X7C; Blood or Tissue &#X7C; Mutations|Pelizaeus-Merzbacher-Like Disease, 1|Peroxisomal Biogenesis Disorder|Zellweger Syndrome|Refsum Disease|Salla Disease|Sialic Storage Disease|Sjögren|Sjogren-Larsson Syndrome|Van Der Knapp Disease|Vanishing White Matter Disease|Charcot-Marie-Tooth|CMT|Mct8 (Slc16A2)-Specific Thyroid Hormone Cell Transporter Deficiency|Allan-Herndon-Dudley Syndrome|Cadasil|Cockayne Syndrome|Multiple Sulfatase Deficiency|Gangliosidoses|GM2 Gangliosidosis|BPAN|Labrune Syndrome|LCC|Mucopolysaccharidoses|TBCK-Related Intellectual Disability Syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of a Multidisciplinary Intensive Management Clinic on Outcomes in Multi-Ethnic Asian Incident Hemodialysis Patients
Status: UNKNOWN
Conditions: Stage 5 Chronic Kidney Disease
Interventions: OTHER: Multidisciplinary, intensive and collaborative care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Compare the Effect of Green Tea Mouthwash vs Chlorohexidine Mouthwash in Children With Plaque-induced Gingivitis
Status: NOT_YET_RECRUITING
Conditions: Plaque Induced Gingivitis
Interventions: DRUG: Green tea mouthwash|DRUG: Chlorhexidine mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Treatments on Pain and Quality of Life in Individual With Burning Mouth Syndrome
Status: RECRUITING
Conditions: Burning Mouth Syndrome
Interventions: DRUG: topical placebo tablet|DRUG: topical clonazepam tablet|DIETARY_SUPPLEMENT: oral alpha-lipoic acid capsule|OTHER: topical phytotherapic capsaicin gel|RADIATION: local photobiomodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Endpoint Bioequivalence Study to Assess Efficacy and Safety of Ivermectin 0.5% Lotion in the Treatment of Head Lice
Status: COMPLETED
Conditions: Head Lice
Interventions: DRUG: Ivermectin 0.5% Topical Application Lotion|DRUG: Ivermectin 0.5% Topical Application Lotion [SKLICE]|DRUG: Placebo 0% Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MI Varnish for the Prevention of White Spot Lesions
Status: COMPLETED
Conditions: White Spot Lesion|Orthodontic Treatment
Interventions: DRUG: MI Varnish|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Techniques and Pitfalls of Multi-Slice CT Coronary Angiography
Status: RECRUITING
Conditions: Computed Tomography Angiography|Coronary Artery Disease
Interventions: RADIATION: Coronary computed tomography angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Organochlorine Concentration in Adipose Tissue and Pancreatic Adenocarcinoma
Status: UNKNOWN
Conditions: Carcinoma|Pancreatic Ductal
Interventions: OTHER: Adipose tissue sampling during surgery and urine sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Open-label, Phase 1 Study to Determine the Maximum Tolerated Dose of HLX07,in Patients With Advanced Solid Cancers
Status: COMPLETED
Conditions: Solid Tumour
Interventions: DRUG: HLX07|DRUG: Acetaminophen|DRUG: dexamethasone|DRUG: diphenhydramine|DRUG: 5-HT3 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sensitivity and Specificity of TSA-CBA for Autoantibodies Against Neural Antigen Determination
Status: UNKNOWN
Conditions: NMO Spectrum Disorder|NMDA-R Encephalitis|Diagnostic Self Evaluation|Immune System Diseases|Nervous System Diseases|Autoimmune Diseases of the Nervous System|Autoimmune Diseases
Interventions: DIAGNOSTIC_TEST: CBA-TSA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CD8+ T Cell Depletion for GVHD Prophylaxis After Peripheral Blood Stem Cell Transplantation
Status: COMPLETED
Conditions: Hematologic Malignancy|AML|ALL|CML|Multiple Myeloma|NHL|Hodgkin's Lymphoma
Interventions: DEVICE: CD+8 T cell depletion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Seraseal for Endoscopic Hemostasis
Status: COMPLETED
Conditions: Gastrointestinal Hemorrhage
Interventions: DEVICE: Seraseal / Fastact Hemostatic agent (combined activated factors IIa, VIIa, IXa, Xa )
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability and Preliminary Efficacy of NGI226 Microparticles in Patients With Achilles Tendinopathy
Status: RECRUITING
Conditions: Achilles Tendinopathy
Interventions: DRUG: NGI226|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cholecalciferol Supplementation in Restless Leg Syndrome in Patients With Chronic Kidney Disease
Status: WITHDRAWN
Conditions: Restless Leg Disorder|Renal Disease Bone|Renal Disease, End Stage|Hyperparathyroidism, Secondary|Adynamic Bone Disease|Vitamin D Deficiency
Interventions: DRUG: Vitamin D|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL
Status: TERMINATED
Conditions: Acute Lymphoblastic Leukemia|Precursor B-Cell Lymphoblastic Leukemia|Precursor T-Cell Lymphoblastic Leukemia
Interventions: DRUG: Decitabine|DRUG: Vorinostat|DRUG: Vincristine|DRUG: Dexamethasone|DRUG: Mitoxantrone|DRUG: Pegaspargase|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension Study to PTR-01-002 (A Study in Recessive Dystrophic Epidermolysis Bullosa (RDEB) Patients Previously Treated With PTR-01)
Status: COMPLETED
Conditions: Recessive Dystrophic Epidermolysis Bullosa
Interventions: DRUG: PTR-01
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3/7 Resistance Training Method in Cardiac Rehabilitation
Status: COMPLETED
Conditions: Heart Failure|Coronary Artery Disease
Interventions: OTHER: 3/7 Resistance Training Method|OTHER: 3X9 Resistance Training Method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CharacterisatiON of carDiac funCTion in Intensive Care Unit Survivors of Sepsis.
Status: RECRUITING
Conditions: Heart Failure|Myocarditis|Sepsis|Septic Shock
Interventions: DIAGNOSTIC_TEST: CMR|DIAGNOSTIC_TEST: hs-troponin|DIAGNOSTIC_TEST: NT-pro BNP|DIAGNOSTIC_TEST: CRP|DIAGNOSTIC_TEST: IL1-B|DIAGNOSTIC_TEST: IL-6|DIAGNOSTIC_TEST: IL-10|DIAGNOSTIC_TEST: TNF-alpha
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: New Genes Involved in Molecular Etiology of Rett Syndrome Through DNA Microarray Comparative Genomic Hybridization
Status: COMPLETED
Conditions: Rett Syndrome
Interventions: PROCEDURE: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gemcitabine Plus Oxaliplatin in Treating Patients With Refractory Locally Advanced or Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Pharmaceutical Interviews Regarding the Management of Adverse Effects Related to the Antibiotic Therapy Used to Treat Osteoarticular Infections During Return Home
Status: COMPLETED
Conditions: Bone and Joint Infection
Interventions: OTHER: pharmaceutical interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: RCT of Efficacy and Safety of Sedation Compared to General Anesthesia for ERCP
Status: TERMINATED
Conditions: Anesthesia|ERCP|Safety|Efficacy
Interventions: DRUG: Propofol|OTHER: General anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Leg Telangiectasias With Nd:YAG 1064nm
Status: UNKNOWN
Conditions: Telangiectasias
Interventions: DEVICE: Laser Nd:YAG 1064nm|OTHER: Sclerotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemoradiation for Bladder Preservation After Complete Response to Neoadjuvant Chemotherapy
Status: TERMINATED
Conditions: Bladder Cancer|Bladder Carcinoma|Transition Cell Cancer|Muscle Invasive Bladder Carcinoma
Interventions: PROCEDURE: Transurethral Resection of the Bladder Tumor & Cystoscopy|RADIATION: Intensity Modulated Radiation Therapy|BEHAVIORAL: Expanded Prostate Cancer Index Composite Short Form 12|BEHAVIORAL: International Prostate Symptom Score
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of DC7-2, a Meat Derived Octapeptide, on Appetite
Status: COMPLETED
Conditions: Appetite; Lack or Loss, Nonorganic Origin
Interventions: DIETARY_SUPPLEMENT: DC7-2|DIETARY_SUPPLEMENT: DC7-2 + potato protein isolate|DIETARY_SUPPLEMENT: Potato protein isolate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: BeneMACS Study:HeartMate 2 (HM2)Left Ventricular Assist Device (LVAD) Survival in Non Transplant Patients is Equal/Better Than Results in Medical Literature
Status: COMPLETED
Conditions: Heart Failure
Interventions: DEVICE: Left Ventricular Assist Device (HeartMate II)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dronedarone Pattern of Use in Patients Scheduled for Elective Cardioversion (ELECTRA)
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: DRUG: Dronedarone|DRUG: Placebo (for dronedarone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Family-Based Mindful Eating Intervention for Overweight Adolescents
Status: COMPLETED
Conditions: Overweight|Adolescent Behavior|Family Research|Weight Loss
Interventions: BEHAVIORAL: Adolescent Mindful Eating Group|BEHAVIORAL: Parent Integrated Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remifentanil and Midazolam on Propofol for Loss of Consciousness
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Propofol|DRUG: Remifentanil|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose:
Clinical trial: Intra-arterial Recombinant Human TNK Tissue-type Plasminogen Activator (rhTNK-tPA) Thrombolysis for Acute Large Vascular Occlusion After Successful Mechanical Thrombectomy Recanalization
Status: RECRUITING
Conditions: Ischemic Stroke, Acute
Interventions: DRUG: Recombinant Human tenecteplase Tissue-type Plasminogen Activator (rhTNK-tPA)|OTHER: Best Medical Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Bevacizumab in Combination With Bortezomib in Patients With Relapsed or Refractory Multiple Myeloma (AMBER)
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Bevacizumab|DRUG: Bortezomib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Neoadjuvant Targeted Treatment to NSCLC Patients
Status: NOT_YET_RECRUITING
Conditions: 2-year Disease-Free Survival
Interventions: DRUG: Oral Navelbine + Carboplatin|DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study to Evaluate the Safety and Efficacy of SKY0402 in Subjects Undergoing Total Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Bupivacaine HCl|DRUG: SKY0402
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Determine if New Types of Malaria Vaccines Are Safe, Effective and Lead to Immunity in Kenyan Adults
Status: UNKNOWN
Conditions: Malaria,Falciparum
Interventions: BIOLOGICAL: R21/Matrix-M|BIOLOGICAL: ChAd63/MVA ME-TRAP|BIOLOGICAL: intradermal injection (ID) or direct venous injection (DVI) of PfSPZ Challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Proof-of-concept Study to Examine QUC398 in Participants With Knee OA
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DRUG: QUC398|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Suction Cervical Stabilizer Compared to Standard Tenaculum for Intrauterine Procedures
Status: RECRUITING
Conditions: Intrauterine Device (IUD)|Abnormal Uterine Bleeding
Interventions: DEVICE: Carevix|DEVICE: Tenaculum
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Continuous Sipping of a Glucose Solution on Markers of Oxidation in Men and Women
Status: COMPLETED
Conditions: Cardiovascular Disease|Diabetes
Interventions: DIETARY_SUPPLEMENT: glucose bolus|DIETARY_SUPPLEMENT: Glucose sipping|DIETARY_SUPPLEMENT: Glucose bolus plus 1g vitamin C|DIETARY_SUPPLEMENT: Glucose sipping plus 1g vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Low-level Laser Therapy on Post-bleaching Sensitivity and Color Change
Status: COMPLETED
Conditions: Tooth Bleaching|Low-level Laser Therapy|Dentin Sensitivity|Clinical Trial
Interventions: RADIATION: Low-lever laser|OTHER: Tooth bleaching|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Inflammation, Proteolysis and IL-1 Beta Receptor Inhibition in Chronic Hemodialysis Patients
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DRUG: kineret|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HepB mAb19 in Individuals With Chronic Hepatitis B Infection
Status: RECRUITING
Conditions: Hepatitis b Virus
Interventions: BIOLOGICAL: HepB mAb19|OTHER: Sterile Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prebiotic Therapy to Improve Outcomes of Renal Transplant
Status: RECRUITING
Conditions: Kidney Transplant; Complications
Interventions: DIETARY_SUPPLEMENT: Human Milk Oligosaccharides (HMO)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: LFMT vs Placebo in New Biologic Start for Ulcerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: Lyophilized fecal microbiota (LFMT)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RJMty19 in Refractory Systemic Lupus Erythematosus (SLE)
Status: NOT_YET_RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: RJMty19 (CD19-CAR-DNT cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of TMZ Plus CDDP in the Patients With Recurrent Malignant Gliomas
Status: UNKNOWN
Conditions: Malignant Gliomas
Interventions: DRUG: TMZ|DRUG: TMZ plus CDDP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Progesterone for First Trimester Vaginal Bleeding
Status: WITHDRAWN
Conditions: Threatened Abortion|Pre-Eclampsia|Abruptio Placentae|Fetal Growth Retardation|Premature Birth
Interventions: DRUG: dihydroxyprogesterone caproate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Mechanism of EGR2 in Allergic Rhinitis
Status: ENROLLING_BY_INVITATION
Conditions: Rhinitis, Allergic
Interventions: GENETIC: EGR2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: S9901 Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation in Treating Men With Stage III or Stage IV Hodgkin's Disease
Status: TERMINATED
Conditions: Lymphoma
Interventions: BIOLOGICAL: bleomycin sulfate|DRUG: carmustine|DRUG: cyclophosphamide|DRUG: dacarbazine|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: vinblastine|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Positron Emission Tomography (PET) Study to Investigate P2X7 Receptor Occupancy by JNJ-55308942 Using [18F]-JNJ-64413739
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-55308942|DRUG: [18F]-JNJ-64413739
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: FeNO After Hypoxia in Asthma Patients
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: hypoxia in hypoxic chamber|DEVICE: sham hypoxia in hypoxic chamber|PROCEDURE: Pulse oximetry|OTHER: Asthma and Quality of Life Questionnaires|PROCEDURE: Lung function testing|PROCEDURE: Blood taking|PROCEDURE: FeNO measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The PertADO Geneva Trial
Status: COMPLETED
Conditions: Pertussis
Interventions: BIOLOGICAL: Pertagen® aP + Td-pur®|BIOLOGICAL: Boostrix® dTpa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Rifampin on the Pharmacokinetics of Ixabepilone in Patients With Advanced Cancer
Status: COMPLETED
Conditions: Advanced Solid Tumors|Neoplasms
Interventions: DRUG: ixabepilone|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TG103 Injection in the Management of Non-diabetic Overweight or Obesity
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Overweight
Interventions: DRUG: TG103 7.5 mg|DRUG: Placebo 7.5 mg|DRUG: TG103 15 mg|DRUG: Placebo 15 mg|DRUG: TG103 22.5 mg|DRUG: Placebo 22.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Yoga Program for Improving the Quality of Life in Couples Coping With Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Carcinoma|Lung Carcinoma|Malignant Head and Neck Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Best Practice|PROCEDURE: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Yoga
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Application of 3D Printing Guide Plate in Spinal Minimally Invasive and Interventional Surgeries
Status: NOT_YET_RECRUITING
Conditions: Lumbar Disc Herniation|Lumbar Spinal Stenosis|Radiculopathy|Lumbosacral Facet Joint Syndrome|Ischemic Pain of the Lower Extremity|Spinal Minimally Invasive and Interventional Surgeries|3D Printing Guide Plate|Radicular Pain|Low Back Pain
Interventions: OTHER: 3D printing guide plate|OTHER: Conventional guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TIL Therapy for Metastatic Ovarian Cancer
Status: COMPLETED
Conditions: Metastatic Ovarian Cancer
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|BIOLOGICAL: TIL infusion|DRUG: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Panomics Relationships in the Epidemiology of Cancer Through In Silico Expression (PRECISE)
Status: WITHDRAWN
Conditions: Cancer|Patients With Clinical and Environmental Risk Factors for Cancer|Patients With a Suspected or Confirmed Diagnosis of Cancer
Interventions: OTHER: Patients with CA or suspected risk of CA or a family Hx
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Angiotensin II Blockade for Chronic Allograft Nephropathy
Status: COMPLETED
Conditions: Kidney Disease|Proteinuria
Interventions: DRUG: Losartan 100mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Vanguard™ Deep Dish Rotating Platform Knee Clinical Evaluation
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: Vanguard™ Deep Dish Rotating Platform Knee|DEVICE: Vanguard™ Cruciate Retaining Knee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate BMS-986141 Added on to Aspirin or Ticagrelor or the Combination, on Thrombus Formation in a Thrombosis Chamber Model in Participants With Stable Coronary Artery Disease and Healthy Participants
Status: COMPLETED
Conditions: Coronary Artery Disease|Healthy Participants
Interventions: DRUG: Ticagrelor|DRUG: BMS-986141|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Study to Evaluate the Effects of Switching to Aripiprazole 12 Weeks on the Sexual Dysfunction From Risperidone or Paliperidone in Patients With Schizophrenia Spectrum Disorders or Bipolar Spectrum Disorders
Status: UNKNOWN
Conditions: Sexual Dysfunction|Hyperprolactinemia
Interventions: DRUG: Aripiprazole|DRUG: risperidone or paliperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Potential Impact of Computerized Antimicrobial Stewardship
Status: COMPLETED
Conditions: Antimicrobial Stewardship|Cardiovascular Surgeries|Computerized Decision Support System|Coronary Artery Disease|Valve Heart Disease
Interventions: OTHER: Computer based Antimicrobial stewardship (AMS) intervention system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Tracheal Intubation in Morbidly Obese (BMI>35) and in Lean (BMI<30) Patients Using McGrath MAC X-Blade
Status: COMPLETED
Conditions: Obesity, Morbid
Interventions: DEVICE: lean|DEVICE: obese
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation Of Missed Osteoporosis Diagnoses, And Preference Between Once Monthly Ibandronate And Once Weekly Alendronate
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Ibandronate|DRUG: Alendronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Evaluating Gastrointestinal Damage Following Administration PL3100 or Naproxen in At-Risk Adults
Status: COMPLETED
Conditions: Gastroduodenal Ulcerations|Erosion
Interventions: DRUG: PL3100|DRUG: Naproxen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial of CD19 and CD22 CAR Sequential Therapy Versus Single CD19 CAR Bridging to HSCT for r/r B-ALL Patients
Status: RECRUITING
Conditions: B-cell Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia, in Relapse|Refractory Acute Lymphoid Leukemia
Interventions: DRUG: CD19 CAR T-cell|DRUG: CD22 CAR T cells|PROCEDURE: hematopoietic stem-cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Assess the Safety of Extended Release Alprazolam for the Treatment of Adolescents With Panic Disorder or Anxiety With Panic Attacks
Status: TERMINATED
Conditions: Panic Disorder
Interventions: DRUG: alprazolam XR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Post-Market Study of the AMS AdVance™ Male Sling System for the Treatment of Male Stress Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: American Medical Systems (AMS) AdVance™ Male Sling System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Safety and the Pharmacokinetics of UI068 in Healthy Adult Volunteers Under Fed Conditions
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: administration of UI068|DRUG: administration of UIC202205, UIC202206
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of An NK-1 Anti-Emetic Medication For The Prevention Of Post-Operative Nausea And Vomiting In Female Patients
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting|Nausea and Vomiting, Postoperative
Interventions: DRUG: GW597599
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Utidelone (UTD1) Plus Capecitabine in Non-pCR TNBC After Neoadjuvant Therapy
Status: RECRUITING
Conditions: Triple Negative Breast Neoplasms
Interventions: DRUG: UTD1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Investigation of the Medical Device Apneal® on Smartphone for Sleep Apnea-Hypopnea Syndrome Diagnosis
Status: RECRUITING
Conditions: Sleep Apnea Syndromes
Interventions: DEVICE: Apneal device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessment of Lung Function After Single Inhalations of a Bronchodilator From 2 Configurations a Dry Powder Inhaler.
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK573719 62.5 mcg (one strip)|DRUG: GSK573719 62.5 mcg(two strips)|DRUG: GSK573719 125 mcg (one strip)|DRUG: GSK573719 125 mcg(two strips)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of Empagliflozin (BI 10773) and Sitagliptin Versus Placebo Over 76 Weeks in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: BI 10773|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: BI 10773|DRUG: Placebo|DRUG: Placebo|DRUG: BI 10773|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: BI 10773|DRUG: BI 10773|DRUG: BI 10773|DRUG: Placebo|DRUG: BI 10773|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Sitagliptin 100mg|DRUG: BI 10773|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Fatty Acid Deficiency Replacement in Early Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Fatty Acid Deficiency
Interventions: DIETARY_SUPPLEMENT: Omega-3 Fatty Acids|OTHER: Olive oil placebo|DIETARY_SUPPLEMENT: EPA fish oil concentrate; DHA fish oil concentrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Local Minocycline in Patients Under Supportive Periodontal Therapy
Status: COMPLETED
Conditions: Periodontitis
Interventions: DRUG: 2% minocycline hydrochloride controlled-delivery system (MHS)|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Saxagliptin and Glucophage Combination Formulations in Healthy Subjects (B)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Saxagliptin|DRUG: Metformin IR (glucophage)|DRUG: Saxagliptin + Metformin IR (FDC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: LIBERTY EXTENSION: Efficacy and Safety Extension Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids
Status: COMPLETED
Conditions: Heavy Menstrual Bleeding|Uterine Fibroid
Interventions: DRUG: Relugolix|DRUG: Estradiol/norethindrone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Absorptive Clearance in the Cystic Fibrosis Airway
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: OTHER: Technetium [Tc-99m] sulfur colloid and Indium [In-111] DTPA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Best Regimen for Phenylephrine Administration During Cesarean Section
Status: COMPLETED
Conditions: Cesarean Section|Cardiac Output|Hypotension
Interventions: DRUG: Phenylephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-pressure vs Standard-pressure in Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Laparoscopic Surgery|Pneumoperitoneum|Cholecystitis; Choledocholithiasis|Quality of Life|Postoperative Nausea and Vomiting|Postoperative Pain|Satisfaction, Patient
Interventions: OTHER: Low-pressure pneumoperitoneum|OTHER: Standard pressure pneumoperitoneum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Home-Based Program to Treat High Blood Pressure in African Americans
Status: COMPLETED
Conditions: Cardiovascular Diseases|Heart Diseases|Hypertension
Interventions: BEHAVIORAL: Health Education Program|BEHAVIORAL: Basic Group|BEHAVIORAL: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arteriovenous Loop Graft for Free Functional Gracilis Transfer in Brachial Plexus Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Brachial Plexus Injury
Interventions: PROCEDURE: Arteriovenous loop graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ureteroscopic Laser Modality on Total Lasing Time and Total Energy in Patients With Large, Dense Renal Calculi
Status: RECRUITING
Conditions: Renal Calculi
Interventions: DEVICE: MOSES laser system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Remimazolam in OPCAB Surgery
Status: UNKNOWN
Conditions: Coronary Artery Bypass Surgery
Interventions: DRUG: Remimazolam Injection [Byfavo]|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Nilotinib vs Imatinib in Adult Patients With Philadelphia (Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP)
Status: TERMINATED
Conditions: Myelogenous Leukemia
Interventions: DRUG: Imatinib|DRUG: Nilotinib (AMN107)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Traditional Chinese Medicine on Gut Microbiota and Allergic Diseases
Status: UNKNOWN
Conditions: Allergic Rhinitis
Interventions: DRUG: Bu-Zhong-Yi-Qi-Tang|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: In Vivo Effects of the Gluten Friendly Bread in Coeliac Disease
Status: TERMINATED
Conditions: Celiac Disease
Interventions: DIETARY_SUPPLEMENT: Gluten Friendly bread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intrathecal Levobupivacaine With Opioids for Caesarean Section
Status: COMPLETED
Conditions: Elective Caesarean Section Surgeries
Interventions: DRUG: Control Group Chirocaine|DRUG: Group Fentanyl|DRUG: Group sufentanil|DRUG: Ephedrine|DRUG: Atropine sulfate|DRUG: Propofol|DRUG: Metoclopramide|DRUG: Diphenhydramine|DRUG: pethidine hydrochloride|DRUG: Diclofenac sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neurophysiologic Monitoring of Antidepressant Treatment
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: fluoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Early Vascular Adjustments During Hypertensive Pregnancy
Status: UNKNOWN
Conditions: Hypertension, Pregnancy-Induced|Pre-Eclampsia
Interventions: DRUG: Labetalol|DRUG: Nifedipine|DRUG: Methyldopa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 2/ 3 Trial to Evaluate the Efficacy and Safety of BAY86-6150
Status: COMPLETED
Conditions: Hemophilia A, Hemophilia B
Interventions: DRUG: BAY86-6150|DRUG: eptacog alfa [activated]|DRUG: BAY86-6150
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of NMS-03597812 in Adult Patients With Relapsed/Refractory Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Relapsed/Refractory Acute Myeloid Leukemia
Interventions: DRUG: NMS-03597812
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-42160443 in Patients With Neuropathic Pain (Postherpetic Neuralgia and Post-traumatic Neuralgia)
Status: TERMINATED
Conditions: Pain|Neuralgia, Postherpetic|Neuralgia|Mononeuropathies
Interventions: DRUG: JNJ-42160443|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Choice of Material for Above-Knee Femoro-Popliteal Bypass Prosthetic Graft (PopUp)
Status: COMPLETED
Conditions: Intermittent Claudication|Critical Limb Ischemia
Interventions: DEVICE: 6 mm Uni-graft® (B-Braun)|DEVICE: 6 mm Gore-Tex® (WL Gore)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Free Walking Exercise in Obstructive Sleep Apnea Patients With Non-alcoholic Fatty Liver
Status: RECRUITING
Conditions: Obstructive Sleep Apnea|Non-alcoholic Fatty Liver
Interventions: BEHAVIORAL: continuous positive airway pressure|BEHAVIORAL: free walking exercise and continuous positive airway pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Prophylactic Antipyretics on Immune Responses and Fever After 2014-2015 and 2015-2016 Inactivated Influenza Vaccine
Status: COMPLETED
Conditions: Fever
Interventions: OTHER: Acetaminophen Arm|OTHER: Placebo Arm|OTHER: Ibuprofen Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PK-directed Dose Adjustment of IV Busulfan Conditioning Regimen for Autologous Stem Cell Transplant in Lymphoma Patients
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: IV Busulfan, Cyclophosphamide and Etoposide (BuCyE Regimen)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Lymphoma|Lymphoproliferative Disorder|Small Intestine Cancer|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: imetelstat sodium|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Distal Malignant Biliary Obstruction by Uncovered, Partially Covered, or Fully Covered Metal Stents
Status: RECRUITING
Conditions: Pancreatic Cancer Non-resectable|Bile Duct Cancer|Papillary Carcinoma|Duodenal Cancer
Interventions: PROCEDURE: Randomization to uncovered SEMS treating jaundice due to distal malignant biliary obstruction.|PROCEDURE: Randomization to partially covered SEMS treating jaundice due to distal malignant biliary obstruction.|PROCEDURE: Randomization to fully covered SEMS treating jaundice due to distal malignant biliary obstruction.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AngioJET Thrombectomy and STENTing for Treatment of Acute Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DEVICE: rheolytic thrombectomy with direct stenting|DEVICE: direct stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multiple Ascending Dose Study of ACN00177 (Pegtarviliase) in Subjects With CBS Deficiency
Status: TERMINATED
Conditions: Homocystinuria Due to Cystathionine Beta-Synthase Deficiency
Interventions: DRUG: Pegtarviliase IV|DRUG: Pegtarviliase SC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Randomized, Double-blind Trial Evaluating the Effects of Chloroquine in Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer|Invasive Breast Cancer
Interventions: DRUG: Chloroquine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Label Phase IV Study to Evaluate Dapagliflozin Treatment in Type 2 Diabetes Mellitus Patients With Impaired Renal Function
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Impaired Renal Function
Interventions: DRUG: Dapagliflozin 10 MG [Farxiga]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genistein in Treating Patients Undergoing External-Beam Radiation Therapy for Bone Metastases
Status: WITHDRAWN
Conditions: Breast Cancer|Kidney Cancer|Lung Cancer|Melanoma|Metastatic Cancer|Pain|Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: genistein|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT