pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Immediate vs Delayed Placement of Straumann BLX Implants in Molar Extraction Sockets
Status: WITHDRAWN
Conditions: Immediate Placement of Straumann BLX Implants in Molar Extraction Sockets
Interventions: DEVICE: Immediate placement non-occlusal loading molar implant (Straumann BLX 6.5mm)|DEVICE: Delayed placement non-occlusal loading molar implant (Straumann BLX 5.0mm)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Hypo-fractionated Neoadjuvant Radiotherapy for Locally Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer|Chemoradiation
Interventions: RADIATION: Hypo-fractionated radiotherapy|DRUG: S1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increasing Linkage to Family Planning Care for Individuals With Substance Use Disorder
Status: COMPLETED
Conditions: Family Planning Services|Substance-Related Disorders|Opiate Substitution Treatment|Sexual Health
Interventions: BEHAVIORAL: Sexual Health Initiative for Navigation and Education (SHINE) Health Educator Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Real-World Clinical Outcomes and Toxicity in Metastatic Breast Cancer Patients Treated With First or Second Line CDK 4/6 Inhibitors and Endocrine Therapy
Status: COMPLETED
Conditions: Toxicity, Drug|Progression, Disease
Interventions: DRUG: CDK4/6 Inhibitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Emergency Department Triage of Patients With Acute Chest Pain Based on the ESC 0/1-hour Algorithm (PRESC1SE-MI)
Status: RECRUITING
Conditions: Acute Chest Pain|NSTEMI - Non-ST Segment Elevation MI
Interventions: DIAGNOSTIC_TEST: European Society of Cardiology hs-cTnT/I 0 h/1 h algorithm|DIAGNOSTIC_TEST: European Society of Cardiology hs-cTnT/I 0 h/3 h algorithm
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Safety, Tolerability and Effects of Single Ascending Doses of ASP3652 in Healthy Subjects
Status: COMPLETED
Conditions: Pharmacokinetics|Pharmacodynamics|Healthy Subjects|Safety
Interventions: DRUG: ASP3652|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Spinal Cord Stimulation for Gait Dysfunction in Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease|Freezing of Gait
Interventions: DEVICE: Spinal Cord Stimulation - High Frequency SCS|DEVICE: Spinal Cord Stimulation - Burst SCS|DEVICE: Spinal Cord Stimulation - Sham SCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide and Alemtuzumab In Lymphoma
Status: TERMINATED
Conditions: Non Hodgkin Lymphoma|High-grade B-cell Lymphoma|Diffuse Large B Cell Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-Contrast Perfusion Using Arterial Spin Labeled MR Imaging for Assessment of Therapy Response in Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma
Interventions: PROCEDURE: MRI with Arterial Spin Labeling (ASL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Catheter Ablation Versus Medical Rate Control for Atrial Fibrillation in Patients With Heart Failure
Status: COMPLETED
Conditions: Atrial Fibrillation|Heart Failure
Interventions: DRUG: Medication to control ventricular rate in AF|PROCEDURE: Catheter Ablation for Persistent Atrial Fibrillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robot-Assisted Intelligent Rehabilitation Treatment for Methamphetamine Use Disorders.
Status: UNKNOWN
Conditions: Amphetamine Addiction
Interventions: DEVICE: robot-assisted rehabilitation intelligent treatment|OTHER: standard psychotherapy treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Orthogonal Polarisation Study in Young, Elderly and Type 2 Diabetics
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Glucose|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dapagliflozin With or Without Spironolactone for HFpEF
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: Dapagliflozin|DRUG: Spironolactone + Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial to Improve Mobility After Hospitalization
Status: ENROLLING_BY_INVITATION
Conditions: Hypertension|Diabetes|Heart Failure|Ambulatory Difficulty|Mobility Limitation
Interventions: BEHAVIORAL: Social Support Gamification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers
Status: TERMINATED
Conditions: Venous Ulcer|Venous Stasis Ulcer|Ulcer
Interventions: BIOLOGICAL: HP802-247|OTHER: HP802-247 Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution in Patients With POAG or OHT
Status: COMPLETED
Conditions: Glaucoma and Ocular Hypertension
Interventions: DRUG: DE-117|DRUG: 0.0015% tafluprost|DRUG: DE-117 and 0.0015% tafluprost|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Examining The Effect of Chronotype Differences on Sleep Quality and Pregnancy Symptoms in Pregnant Women
Status: COMPLETED
Conditions: Chronotype|Pregnancy Complications
Interventions: OTHER: Morning chronotype|OTHER: Intermediate chronotype|OTHER: Evening chronotype
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Delirium, Agitation/Sedation, Pain and Dyspnea in Respiratory Intensive Care Unit (NIVILIUM)
Status: RECRUITING
Conditions: Respiratory Failure|Delirium|Agitation,Psychomotor|Pain|Dyspnea|Mechanical Ventilation Complication
Interventions: OTHER: Observation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Safety, Tolerability and Effectiveness of MT-0814 for the Treatment of Age-related Macular Degeneration
Status: TERMINATED
Conditions: Age-related Macular Degeneration
Interventions: DRUG: MT-0814|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of SGLT2 Inhibition Treatment on Different Levels of Albuminuria in Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes|Diabetic Nephropathy
Interventions: DRUG: SGLT2 Inhibition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Herbal Tea in Type 2 Diabetics
Status: COMPLETED
Conditions: Type 2 Diabetes|Herbal Medicine Adverse Reaction
Interventions: DIETARY_SUPPLEMENT: Antidiabetic Herbal Tea|DIETARY_SUPPLEMENT: Herbal Tea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Neurotech Vital Device For The Treatment Of Stress Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: Active Neurotech Vital|DEVICE: Modified Neurotech Vital Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: KRAS-Targeted Vaccine With Nivolumab and Ipilimumab for Patients With NSCLC
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Pooled Mutant KRAS-Targeted Long Peptide Vaccine 0.3mg each; 1.8mg total peptides
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Descending Age Study of P2VP8 Subunit Parenteral Rotavirus Vaccine in Healthy Toddlers and Infants
Status: COMPLETED
Conditions: Evaluation of a Rotavirus Vaccine
Interventions: BIOLOGICAL: P2-VP8 Subunit Vaccine 10mcg|BIOLOGICAL: P2-VP8 Subunit Vaccine 30 mcg|BIOLOGICAL: P2-VP8 Subunit Vaccine 60mcg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Trial of 18F-AV-133 Positron Emission Tomography (PET)
Status: TERMINATED
Conditions: Type 1 Diabetes|Type 2 Diabetes
Interventions: DRUG: 18F-AV-133
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Therapeutic Value of Periorbital Injection of Glucocorticoid in Mild TAO
Status: UNKNOWN
Conditions: Thyroid Associated Ophthalmopathy
Interventions: DRUG: Glucocorticoids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RCT of an Integrative Intervention for Non-Treatment-Seeking Meth Users
Status: COMPLETED
Conditions: HIV/AIDS|Stimulant Use Disorders
Interventions: BEHAVIORAL: Affect Regulation Treatment to Enhance Meth Intervention Success (ARTEMIS)|BEHAVIORAL: Contingency Management (CM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of MIGRA-ZEN RELIEF PLUS In the Treatment of Chronic Migraine Headache
Status: UNKNOWN
Conditions: Chronic Migraine
Interventions: DIETARY_SUPPLEMENT: MIGRA-ZEN RELIEF PLUS|DIETARY_SUPPLEMENT: Placebo for Migrazen relief plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Oral Iron Repletion Effects On Oxygen Uptake in Heart Failure
Status: COMPLETED
Conditions: Chronic Heart Failure
Interventions: DRUG: Polysaccharide Iron Complex 150 mg|DRUG: Placebo (for Polysaccharide Iron Complex)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Oral Vadadustat in Pediatric Participants With Anemia of Chronic Kidney Disease Naive to Erythropoiesis-Stimulating Agents
Status: SUSPENDED
Conditions: Anemia of Chronic Kidney Disease
Interventions: DRUG: Vadadustat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-centered and Neurocognitive Outcomes With Acetazolamide for Sleep Apnea
Status: RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: Acetazolamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reduction of Ischemic Myocardium With Ranolazine-Treatment in Patients With Acute Myocardial Ischemia
Status: COMPLETED
Conditions: Coronary Artery Disease|Acute Myocardial Ischemia
Interventions: DRUG: Ranolazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Efficiency of a Voriconazole Preemptive Genotyping Strategy
Status: UNKNOWN
Conditions: Invasive Fungal Infections
Interventions: DRUG: Voriconazole preemptive genotyping strategy|DRUG: Voriconazole clinical practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Condylar Position Changes and TMJ Functions After BSSO Mandibular Setback, Low Medial Cut.
Status: ACTIVE_NOT_RECRUITING
Conditions: Maxillofacial Abnormalities|Mandible Prognathism|Skeletal Malocclusion
Interventions: OTHER: mandibular setback using BSSRO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Insomnia for Adolescents With Mild Traumatic Brain Injury
Status: COMPLETED
Conditions: Mild Traumatic Brain Injury|Post-Concussion Syndrome|Insomnia
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy for Insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pasireotide in Hyperinsulinemic Hypoglycemia
Status: WITHDRAWN
Conditions: Congenital Hyperinsulinism|Insulinoma|Hyperinsulinism
Interventions: DRUG: Pasireotide 0.6Mg Solution for Injection|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Sacituzumab With Chemoimmunotherapy to Treat Advanced Triple-Negative Breast Cancer After Prior Therapies
Status: TERMINATED
Conditions: Advanced Triple Negative Breast Cancer
Interventions: BIOLOGICAL: N-803|BIOLOGICAL: PD-L1 t-haNK|DRUG: Sacituzumab Govitecan-Hziy|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Ravicti™ in Patients With MCAD Deficiency With the 985A>G (K304E) Mutation
Status: COMPLETED
Conditions: Medium-chain Acyl-CoA Dehydrogenase (MCAD) Deficiency
Interventions: DRUG: Ravicti
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Assess the Effects of an Antimicrobial Mouthwash on the Esophageal Microbiome
Status: COMPLETED
Conditions: Esophageal Adenocarcinoma|Barrett's Esophagus|Reflux Esophagitis
Interventions: DRUG: Chlorhexidine gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Two Treatments for Chronic Post Concussion Syndrome
Status: TERMINATED
Conditions: Post Concussion Syndrome|Head Injury
Interventions: BEHAVIORAL: Psychoeducation|BEHAVIORAL: Relaxation Training|BEHAVIORAL: Interoceptive Exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study on the Comparison Between"Standard Noodles" and Traditional Carbohydrates in the Diagnosis of Diabetes Mellitus.
Status: UNKNOWN
Conditions: Diabetes
Interventions: OTHER: 100g Standard Noodles|OTHER: 75g Oral Glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Carotid Plaque Assessment Using 18Fluorine (18F) -Sodium Fluoride Positron Emission Tomography (PET) /MR
Status: COMPLETED
Conditions: Carotid Artery Plaque
Interventions: DRUG: 18F-sodium fluoride PET/MR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phenotypic and Genetic Correlates of Diabetes (Non-Type 1) in Young Non-Obese Asian Indians in North India and A Study to Evaluate the Efficacy of Sitagliptin (DPP-4 Inhibitor) in a Sub-group of the Study Population
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Metformin|BEHAVIORAL: Lifestyle modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Auditory Stimulation by Family Voices in Preventing Delirium: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Delirium
Interventions: OTHER: structured family voice stimulation|OTHER: unstructured family voice stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Interscalene Block Versus Supraclavicular Block for Shoulder Surgery
Status: COMPLETED
Conditions: Pain, Postoperative|Shoulder Pain|Surgical Procedure, Unspecified|Diaphragmatic Paralysis
Interventions: PROCEDURE: Interscalene block|PROCEDURE: Supraclavicular block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy Trial of a Brief Parent-Based Adolescent Sexual Health Intervention
Status: COMPLETED
Conditions: Increase HPV Vaccination Uptake|Delay Sexual Debut
Interventions: BEHAVIORAL: Families Talking Together Plus (FTT+HPV)|BEHAVIORAL: Brief motivational interviewing (BMI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: mWACh-PrEP: A SMS-based Support Intervention to Enhance PrEP Adherence During Pregnancy and Breastfeeding
Status: RECRUITING
Conditions: HIV Infections|Pregnancy Related|Adherence, Medication
Interventions: BEHAVIORAL: mWACh-PrEP|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clopidogrel and Aspirin for the Treatment of Polycythemia Vera
Status: WITHDRAWN
Conditions: Polycythemia Vera
Interventions: DRUG: Clopidogrel (Plavix)|DRUG: Placebo|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oxygen for Intrauterine Resuscitation of Category II Fetal Heart Tracings
Status: COMPLETED
Conditions: Electronic Fetal Monitoring|Fetal Hypoxia|Fetal-Placental Circulation
Interventions: DRUG: Room air|DRUG: 10L Oxygen by nonrebreather mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Influencing Factors of 12 Week Efficacy of Polyethylene Glycol Losenatide in Type 2 Diabetes Patients
Status: RECRUITING
Conditions: Type2 Diabetes Mellitus
Interventions: DRUG: Polyethylene Glycol Losenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dosimetry Based PRRT Versus Standard Dose PRRT With Lu-177-DOTATOC in NEN Patients
Status: RECRUITING
Conditions: Neuroendocrine Neoplasm
Interventions: DRUG: Lu-177-DOTA-Octreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study to Evaluate the Efficacy of RUTI® Against SARS-COV-2 Infection (COVID-19) in Healthcare Workers
Status: COMPLETED
Conditions: Covid-19
Interventions: BIOLOGICAL: RUTI® vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma
Status: RECRUITING
Conditions: Ependymoma|Glioblastoma|Medulloblastoma|Recurrent Metastatic Malignant Neoplasm in the Leptomeninges
Interventions: BIOLOGICAL: IL13Ralpha2-specific Hinge-optimized 41BB-co-stimulatory CAR Truncated CD19-expressing Autologous T-Lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myofunctional Therapy in Patients With Mild-moderate Sleep Apnea
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea of Adult|Myofunctional Therapy
Interventions: OTHER: Myofunctional Therapy|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pelvic Floor Muscles and Stabilization Integrated Training Improved Pregnancy-related Pelvic Girdle Pain
Status: COMPLETED
Conditions: Pelvic Girdle Pain
Interventions: OTHER: isolated pelvic floor muscles training|OTHER: comprehensive stabilization exercise program|OTHER: education of pelvic girdle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Two-Part First-In-Human Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GUB014295
Status: RECRUITING
Conditions: Healthy Volunteers|Overweight
Interventions: DRUG: GUB014295|DRUG: GUB014295-PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Duration of Stretching Exercises for Chronic Non-specific Neck Pain Patients
Status: COMPLETED
Conditions: Myofascial Pain Syndrome
Interventions: OTHER: Stretching exercises|OTHER: Placebo stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Tolerability Study of Azilsartan Medoxomil in Participants With Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Azilsartan medoxomil|DRUG: Azilsartan medoxomil, with or without chlorthalidone and other non-angiotensin II receptor blocker antihypertensive medications.|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High FODMAP Diet With Metformin in preDM
Status: NOT_YET_RECRUITING
Conditions: PreDiabetes|Impaired Glucose Tolerance
Interventions: COMBINATION_PRODUCT: High FODMAP diet with metformin|COMBINATION_PRODUCT: Low FODMAP diet with metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Effectiveness of an Attachment-Focused Intervention in Preschool Children With FASD
Status: COMPLETED
Conditions: Fetal Alcohol Spectrum Disorder|Attachment Disorders
Interventions: BEHAVIORAL: Circle of Security (COS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Muscle Strength Training in Post-Covid Syndrome
Status: RECRUITING
Conditions: Cardiovascular Abnormalities|Post-COVID-19 Syndrome|Physical Exercise
Interventions: OTHER: Inspiratory muscle strength training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RC48-ADC Combined With AK104 For Perioperative Treatment of Muscle-Invasive Bladder Cancer
Status: RECRUITING
Conditions: Muscle Invasive Bladder Carcinoma
Interventions: DRUG: RC48-ADC|DRUG: AK104
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 'Food, Fun, Fresh, Family' Program for Healthy Eating and Growth for Elementary-age Children.
Status: ACTIVE_NOT_RECRUITING
Conditions: Diet, Healthy Growth
Interventions: BEHAVIORAL: Family support|BEHAVIORAL: BGCAA's after-school program with CATCH curriculum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Liposomal Bupivacaine Interscalene Blocks for Rotator Cuff Repair
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: liposomal bupivacaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First in Human, Dose Escalation Study of AN4005
Status: RECRUITING
Conditions: Advanced Solid Tumor|Advanced Lymphoma
Interventions: DRUG: AN4005-dose level 0|DRUG: AN4005-dose level 1|DRUG: AN4005-dose level 2|DRUG: AN4005-dose level 3|DRUG: AN4005-dose level 4|DRUG: AN4005-food effect
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Preliminary Efficacy of Adipose Derived Stem Cells and Low Frequency Ultrasound in PAD
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: BIOLOGICAL: LoFU and aADSC|BIOLOGICAL: adipose derived stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Flow Oxygen During Operative Hysteroscopy.
Status: COMPLETED
Conditions: Endometrium; Hypertrophy, Cervix|Anesthesia|Apnea, Postanesthetic
Interventions: DEVICE: Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE).|DEVICE: LMA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RFA Using Combined Bipolar and Monopolar Energy Deliver With Twin Cooled-Wet Electrodes
Status: UNKNOWN
Conditions: Radiofrequency Ablation|Carcinoma, Hepatocellular
Interventions: PROCEDURE: RFA using combined bipolar and monopolar energy deliver
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Cefazolin With Ertapenem for Methicillin-susceptible Staphylococcus Aureus Bacteremia
Status: RECRUITING
Conditions: Staphylococcus Aureus Bacteremia|Staphylococcus Aureus Septicemia|Staphylococcal Sepsis|Staphylococcus Aureus Endocarditis
Interventions: DRUG: Ertapenem|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase Ib/II Trial of Abemaciclib and Elacestrant in Patients With Brain Metastasis Due to HR+/Her2- Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Abemaciclib|DRUG: Elacestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of EVL\GVS Alone vs. EVL\GVS Combined Propranolol
Status: UNKNOWN
Conditions: Liver Cirrhosis|Hepatoma
Interventions: DRUG: propranolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peginterferon Plus Ribavirin for Hepatitis C Patients Concomitant With Malignancy Other Than Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Chronic Hepatitis C|Neoplasms
Interventions: DRUG: pegylated interferon alpha 2a and plus ribavirin|DRUG: pegylated interferon alpha 2a and plus ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sunitinib in Treating Patients With Relapsed or Refractory Esophageal or Gastroesophageal Junction Cancer
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: sunitinib malate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability Trial of L-Praziquantel in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: MSC2499550A|DRUG: Cysticide|DRUG: MSC2499550A|DRUG: MSC2499550A|DRUG: MSC2499550A|DRUG: MSC2499550A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PACAP38 Induced Headache and Rosacea-like Symptoms in Patients With Rosacea
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: Imigran|OTHER: Isotonic Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An RCT of Oseltamivir in Outpatients With CPD: A Pilot Study.
Status: WITHDRAWN
Conditions: Pulmonary Disease|Influenza
Interventions: DRUG: oseltamivir|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: High Energy Formula Feeding in Infants With Congenital Heart Disease
Status: UNKNOWN
Conditions: Growth Failure|Neurodevelopmental Disorder
Interventions: DIETARY_SUPPLEMENT: High energy formula|DIETARY_SUPPLEMENT: Standard formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Maintenance With Niraparib In Patients With Advanced Urothelial Cancer After 1st-line Platinum-based Chemotherapy
Status: COMPLETED
Conditions: Urothelial Carcinoma
Interventions: DRUG: Niraparib|OTHER: Best supportive care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-Articular Injection of Etanercept in Patient Suffering From Rheumatoid Arthritis : a Double-Blind Randomized Study
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: PROCEDURE: intra-articular injection of etanercept|PROCEDURE: intra-articular injection of steroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Molecular Content of Peri-implant Sulcus During Wound Healing and Osseointegration Following Drilling and Piezosurgery
Status: COMPLETED
Conditions: Tooth Loss|Edentulous Jaw
Interventions: PROCEDURE: Piezosurgery|PROCEDURE: Drill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Neoplasms
Interventions: BIOLOGICAL: Dostarlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RADx-UP- Impact of Community Health Worker Deployment
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes|COVID-19|Community Health Workers|Health Behavior|Health Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: Impact of Community Health Worker Home Deployment on COVID-19 Vaccine Confidence and Uptake
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Evaluation of a Mouthwash Containing Malva Sylvestris Extract.
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: DRUG: experimental group 10% mouthwash of M. sylvestris extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient
Status: RECRUITING
Conditions: Cognitive Decline|Cognitive Change|Cognitive Impairment|Postoperative Delirium|Anesthesia; Reaction|Anesthesia; Adverse Effect
Interventions: COMBINATION_PRODUCT: Neurocognition Interventions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of CYP2C19 Genotype-guided Clopidogrel and Ticagrelor Treatment on Platelet Function Test and Metabolomics Profile
Status: COMPLETED
Conditions: Coronary Artery Disease (CAD)
Interventions: DRUG: Clopidogrel|DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy With MK-3475 in Surgically Resectable Head and Neck Squamous Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer of Head and Neck|Head and Neck Cancer|Neoplasms, Head and Neck|Carcinoma, Squamous Cell of Head and Neck|Squamous Cell Carcinoma of the Head and Neck|Squamous Cell Carcinoma, Head and Neck
Interventions: BIOLOGICAL: MK-3475 (neoadjuvant)|PROCEDURE: Surgery|RADIATION: Intensity modulated radiation therapy|RADIATION: Image-guided radiation therapy|DRUG: Cisplatin|BIOLOGICAL: MK-3475 (adjuvant)|PROCEDURE: Peripheral blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Electronic Monitoring and Feedback on Adherence to Easyhaler Controller Medication in Patients With Asthma
Status: UNKNOWN
Conditions: Asthma
Interventions: OTHER: Reminders and feedback to improve adherence|OTHER: No reminders and feedback to improve adherence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in Patients With Medulloblastomas With an Activation of the Sonic Hedgehog Pathway
Status: TERMINATED
Conditions: Histologically Confirmed Medulloblastoma|Activation of the Sonic Hedgehog (SHH) Pathway
Interventions: DRUG: vismodegib|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sonodynamic Therapy on Patients With Femoropopliteal PAD and Claudication
Status: WITHDRAWN
Conditions: Peripheral Arterial Disease|Atherosclerosis|Cardiovascular Diseases
Interventions: DRUG: Optimal Medical Care|COMBINATION_PRODUCT: Sonodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Genetics Navigator: Evaluating a Digital Platform for Genomics Health Services
Status: NOT_YET_RECRUITING
Conditions: Cardiac Conditions|Connective Tissue Diseases|Retinal Disease|Epilepsy in Children|Neurodevelopmental Disorders|Cancer|Polyposis
Interventions: BEHAVIORAL: Genetics Navigator|BEHAVIORAL: Standard Care with Genetics Professionals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Interest of the Echocardiography in the Management of Cirrhotic Patients With Acute Kidney Injury
Status: COMPLETED
Conditions: Cirrhosis|Hepatorenal Syndrome|Acute Kidney Injury|Diastolic Function
Interventions: PROCEDURE: Echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase I/II Study of Azacitidine, Docetaxel, and Prednisone for Metastatic Prostate Cancer Patients
Status: TERMINATED
Conditions: Prostate Cancer|Pain
Interventions: DRUG: Azacitidine|DRUG: Docetaxel|DRUG: Prednisone|GENETIC: GADD45α methylation and expression analysis|DRUG: Pegfilgrastim|DRUG: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polypodium Leucotomos Extract for the Treatment of Melasma
Status: COMPLETED
Conditions: Melasma
Interventions: DIETARY_SUPPLEMENT: Polypodium leucotomos extract|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Tibial Nerve Stimulation in the Treatment of Anterior Resection Syndrome After Rectal Cancer Surgery
Status: UNKNOWN
Conditions: Rectal Cancer|Low Anterior Resection Syndrome
Interventions: DEVICE: PTNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Human-Milk Based Nutrition Versus Formula in Premature Infants
Status: COMPLETED
Conditions: Infant, Very Low Birth Weight
Interventions: DIETARY_SUPPLEMENT: Pasteurized human milk and pasteurized human milk fortifier|DIETARY_SUPPLEMENT: Pasteurized human milk and pasteurized human milk fortifier|DIETARY_SUPPLEMENT: Human milk fortifier (bovine-based), pre-term formula|DIETARY_SUPPLEMENT: Pasteurized human milk and pasteurized human milk fortifier|DIETARY_SUPPLEMENT: Pre-term/term formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Visio-conference for Pre-hospital Triage of Stroke Suspicions
Status: COMPLETED
Conditions: Stroke|Stroke, Acute|Stroke, Ischemic|Cerebrovascular Disorders
Interventions: PROCEDURE: Visio conference device evaluation (DVCM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination OZURDEX® & LUCENTIS® vs. OZURDEX® Monotherapy in Incomplete-Responders With Diabetic Macular Edema
Status: TERMINATED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Ozurdex|DRUG: Lucentis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Examine the Efficacy and Safety of Meridia® (Sibutramine Hydrochloride) in Binge-Eating Disorder
Status: COMPLETED
Conditions: Binge Eating Disorder|Obesity
Interventions: DRUG: sibutramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of Transdermal Nicotine on Response Inhibition to Emotional Cues in Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia|Impulsive Behavior
Interventions: DRUG: Nicotine Patch, 7 Mg/24 Hr|DRUG: Placebo patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:
Status: ACTIVE_NOT_RECRUITING
Conditions: Pyruvate Dehydrogenase Complex Deficiency
Interventions: DRUG: Dichloroacetate (DCA)|OTHER: Placebo|GENETIC: Genotype
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Bile Acids and Bile Acid Sequestrants on GLP-1 Secretion After Roux-en-Y Gastric Bypass
Status: COMPLETED
Conditions: Severe Obesity
Interventions: DRUG: Colesevelam|DRUG: Chenodeoxycholic Acid|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tenofovir Alafenamide Versus Entecavir for the Treatment of Chronic Hepatitis B
Status: RECRUITING
Conditions: Hepatitis B|Viral Hepatitis
Interventions: DRUG: Tenofovir alafenamide|DRUG: Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Study To Evaluate the Safety, Tolerability and Efficacy of Fesoterodine for Overactive Bladder.
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: fesoterodine fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerability, Safety and Pharmacokinetic Study Of Methosulide in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Methosulide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Carbidopa/Levodopa/Entacapone on Motor Function and Quality of Life in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease With End of Dose Wearing Off
Interventions: DRUG: Carbidopa/levodopa/entacapone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prasugrel Versus High Dose Clopidogrel in Clopidogrel Resistant Patients Post Percutaneous Coronary Intervention (PCI).
Status: COMPLETED
Conditions: Coronary Artery Disease (CAD)|Acute Coronary Syndrome (ACS)
Interventions: DRUG: prasugrel|DRUG: clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tack Optimized Balloon Angioplasty Study of the Tack Endovascular System™ in Femoropoliteal Arteries
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: DEVICE: Tack Endovascular System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Recombinant Vaccinia Virus to Treat Refractory Solid Tumors in Pediatric Patients
Status: COMPLETED
Conditions: Neuroblastoma|Rhabdomyosarcoma|Lymphoma|Wilm's Tumor|Ewing's Sarcoma
Interventions: DRUG: Recombinant Vaccinia GM-CSF; RAC VAC GM-CSF (JX-594)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Observational Study of the PPI Non-responder
Status: WITHDRAWN
Conditions: Gastro Esophageal Reflux Disease PPI Non-Responders
Interventions: DIAGNOSTIC_TEST: EGD with biopsy|DIAGNOSTIC_TEST: EGD and impedance-pH study on PPI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Glutamine Role in Preventing Vaso-occlusive Crisis Among SCD Patients
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: L-Glutamine, Oral Powder for Reconstitution|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Semaglutide Versus Canagliflozin as add-on to Metformin in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide|DRUG: Canagliflozin|DRUG: Placebo (canagliflozin)|DRUG: Placebo (semaglutide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Systemic and Peritoneal Inflammatory Response In Robotic-assisted And Laparoscopic Surgery for Colon Cancer
Status: UNKNOWN
Conditions: Colonic Neoplasms|Colon Cancer|Systemic Inflammatory Response Syndrome|Inflammation|Robotic Surgical Procedures|Laparoscopy|Peritoneal Inflammation
Interventions: PROCEDURE: Robotic-assisted colectomy|PROCEDURE: Conventional laparoscopic colectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: GSK3739937 First-Time-In-Human (FTIH) Study in Healthy Volunteers
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: GSK3739937 (PIB)|DRUG: Placebo|DRUG: GSK3739937 (Tablet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-Inflammatory Activities of Grapes in Humans at Risk for Cardiovascular Disease
Status: COMPLETED
Conditions: Obesity|Inflammation
Interventions: DIETARY_SUPPLEMENT: Grape powder, followed by placebo powder|DIETARY_SUPPLEMENT: Placebo powder followed by grape powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prevalence and Significance of ATTR Aortic Valve Amyloidosis in Degenerative Aortic Stenosis
Status: RECRUITING
Conditions: Amyloidosis
Interventions: DIAGNOSTIC_TEST: Proteomic analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of the Product QGC001 as a Single Dose and Multiple Doses Administered Orally to Healthy Adult Subjects
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: QGC001 [(3S,3'S)-4,4'-dithiobis (3-aminobutane-1-sulfonic acid)]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Eptinezumab as Preventive Treatment of Migraine in Adults With Migraine
Status: ACTIVE_NOT_RECRUITING
Conditions: Migraine
Interventions: DRUG: Placebo|DRUG: Eptinezumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT