pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Empagliflozin in Patients With Autosomal Dominant Polycystic Kidney Disease (EMPA-PKD)
Status: RECRUITING
Conditions: Autosomal Dominant Polycystic Kidney
Interventions: DRUG: Empagliflozin 10 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combine Apatinib Mesylate With PD-1 Antibody SHR-1210 for HCC With High Risk of Recurrence After Radical Resection
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: COMBINATION_PRODUCT: Apatinib Mesylate +SHR-1210|PROCEDURE: Hepatic Arterial Infusion(HAI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictive Value of Serum Uric Acid to HDL Cholesterol Ratio for Diabetic Kidney Injury in Type 2 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Diabetic Kidney Injury
Interventions: DIAGNOSTIC_TEST: serum uric acid level to plasma HDL-c level ratio (UHR)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Paclitaxel, Carboplatin, and PF-05212384 in Advanced or Metastatic NSCLC (UF-STO-LUNG-002)
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Gedatolisib|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Control Trial of Quadratus Lumborum Block for Lumbar Spine Decompression and Fusion Surgery
Status: UNKNOWN
Conditions: Spinal Stenosis Lumbar|Spondylolisthesis|Fusion of Spine, Lumbar Region|Degeneration Spine
Interventions: PROCEDURE: Type 2/posterior Quadratus Lumborum block|PROCEDURE: Placebo block with Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Cognitive Behavioral Digital Therapeutic InterventiON for Glycemic Control in Type 2 Diabetes Mellitus
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Type 2
Interventions: DEVICE: BT-001|DEVICE: Control Mobile Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Usability and Feasibility Testing of the Profound Matrix™ System
Status: ACTIVE_NOT_RECRUITING
Conditions: Wrinkle|Acne Scars - Mixed Atrophic and Hypertrophic
Interventions: DEVICE: Profound Matrix™ System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PROPHESYS 1: An Observational Study on Predictors of Response in Treatment-naïve Patients With Chronic Hepatitis C Virus (HCV)Treated With Pegasys (Peginterferon Alfa-2a)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Peginterferon alfa-2a (Pegasys®)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Atezolizumab in High PD-L1 Expression, Chemotherapy-Naïve Patients With Stage IV Non-Squamous or Squamous Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Transcranial Stimulation (tDCS)to Relieve Neuropathic Pain in Cancer Patients
Status: COMPLETED
Conditions: Pain
Interventions: DEVICE: non-invasive transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Anchoring Guided Endoscopic Submucosal Dissection for Early Gastric Caner
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: PROCEDURE: Magnetic anchored guided endoscopic submucosal dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chlorhexidine vs Povidone Iodine in Alcoholic Solutions for Prevention of Central Venous Catheter Infection
Status: COMPLETED
Conditions: ICU Patients Requiring a Central Venous Access
Interventions: DRUG: Skin disinfection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Schizophrenia and Comorbid Cannabis Use Disorder: Comparing Clozapine to Treatment-as-Usual
Status: COMPLETED
Conditions: Schizophrenia|Dual Diagnosis|Schizoaffective Disorder|Psychotic Disorder|Cannabis Abuse
Interventions: DRUG: Clozapine|DRUG: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MK-1088 as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors (MK-1088-002)
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: DRUG: MK-1088|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Transplantation of Astrocytes Derived From Human Embryonic Stem Cells, in Patients With Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: ALS (Amyotrophic Lateral Sclerosis)
Interventions: BIOLOGICAL: AstroRx
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Presatovir in Lung Transplant (LT) Recipients With Respiratory Syncytial Virus (RSV) Infection
Status: COMPLETED
Conditions: Respiratory Syncytial Virus (RSV)
Interventions: DRUG: Presatovir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect on Bacterial Glycolytic Acid Formation on Plaque
Status: COMPLETED
Conditions: Dental Plaque
Interventions: DRUG: Triclosan, Fluoride|DRUG: fluoride|DRUG: Fluoride, triclosan, amino acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non Inferiority Trial of Standard RT Versus Hypofractionated Split Course in Elderly Vulnerable Patients With HNSCC
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: RADIATION: Standard RT|RADIATION: Hypofractionated RT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study in Healthy Subjects to Examine the Safety and Tolerability of ACT-1004-1239 Given as Multiple, Gradually Increasing Doses and to Examine the Effects of ACT-1004-1239 on the Body and the Way the Body Takes up, Distributes, and Gets Rid of ACT-1004-1239
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ACT-1004-1239|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of the Safety and Efficacy of Razuprotafib in Hospitalized Subjects With Coronavirus Disease 2019
Status: TERMINATED
Conditions: COVID-19|Acute Respiratory Distress Syndrome (ARDS)
Interventions: DRUG: Razuprotafib Subcutaneous Solution|DRUG: Placebo Subcutaneous Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Efficacy of Botox in Bruxism
Status: COMPLETED
Conditions: Bruxism
Interventions: DRUG: Botulinum toxin type A|DRUG: Placebo arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Mindfulness Meditation on Brain Metabolism in the Limbic Regions Studied by Magnetic Resonance Spectroscopy; Correlations With the Memory Performance and Episodic Metamemetory of Students.
Status: NOT_YET_RECRUITING
Conditions: Behavior
Interventions: BEHAVIORAL: 6-week MBSR program|BEHAVIORAL: 6-week muscular relaxation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Correlation of Reduction of Levodopa and Non-motor Symptoms of Parkinson's Disease After Deep Brain Stimulation
Status: COMPLETED
Conditions: Parkinson Disease|Visual Impairment
Interventions: DRUG: Levodopa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of BAT4406F Injection in Patients With Neuromyelitis Optica Spectrum Disorders
Status: RECRUITING
Conditions: Optic Neuromyelitis Spectrum Disease
Interventions: DRUG: BAT4406F Injection|DRUG: BAT4406F Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cranberry Enhances Human Immune Function and Reduces Illness
Status: COMPLETED
Conditions: Healthy Humans
Interventions: DIETARY_SUPPLEMENT: Beverage made to look like the cranberry beverage|DIETARY_SUPPLEMENT: Beverage made from cranberry compounds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: TRAC-ER Intervention to Reduce Risky Alcohol Use Among Sexual Minority Males and Transgender Individuals
Status: NOT_YET_RECRUITING
Conditions: Risk Behavior|Alcohol Use Disorder|HIV Infections
Interventions: BEHAVIORAL: Smartphone Based Alcohol Monitoring (SAM)|BEHAVIORAL: Tracking and Reducing Alcohol Consumption (TRAC)|BEHAVIORAL: TRAC-ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of DA+LDD in the Treatment of Femoropopliteal Occlusive Disease
Status: UNKNOWN
Conditions: Peripheral Artery Disease|Endovascular Treatment
Interventions: DEVICE: directional atherectomy and locol drug delivery|DEVICE: drug-coated balloon dilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of IMR-687 in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Sickle Cell Disease|Sickle-Cell; Hb-SC|Sickle Beta 0 Thalassemia
Interventions: DRUG: IMR-687|DRUG: Placebo Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics Study of Anthrax Immune Globulin Intravenous (AIGIV)
Status: COMPLETED
Conditions: Anthrax
Interventions: BIOLOGICAL: AIGIV 3.5 mg/kg|BIOLOGICAL: Gamunex 90 mg/kg|BIOLOGICAL: AIGIV 7.0 mg/kg|BIOLOGICAL: Gamunex 180 mg/kg|BIOLOGICAL: AIGIV 14.0 mg/kg|BIOLOGICAL: Gamunex 360 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characterization of Myocardial Blood Flow Measurements Using Lexiscan®™ (Regadenoson) (Lexiscan®™) Rubidium-82 Myocardial Perfusion PET: A Temporal-Dependency Investigation
Status: COMPLETED
Conditions: Myocardial Blood Flow Reserve
Interventions: DRUG: Regadenoson|RADIATION: Rubidium-82
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Exercise Combined With Inulin Propionate Ester on Fat Oxidation
Status: COMPLETED
Conditions: Exercise|Inulin Propionate Ester
Interventions: BEHAVIORAL: Exercise training with Inulin Propionate Ester|BEHAVIORAL: Exercise training with placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Long-term, Extension Study of E2020 in Patients With Dementia With Lewy Bodies
Status: COMPLETED
Conditions: Dementia With Lewy Bodies (DLB)
Interventions: DRUG: E2020
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Different Doses of Paracetamol for Post-Operative Pain Relief
Status: COMPLETED
Conditions: Adult Patients Scheduled for 3rd Molar Teeth Extractions
Interventions: PROCEDURE: 3rd molar teeth extraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: REstrictive Versus LIbEral Fluid Therapy in Major Abdominal Surgery: RELIEF Study
Status: COMPLETED
Conditions: Abdominal Surgery
Interventions: OTHER: Liberal fluid therapy|OTHER: Restrictive fluid therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clemastine Fumarate as Remyelinating Treatment in Internuclear Ophthalmoparesis and Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis|Internuclear Ophthalmoplegia
Interventions: DRUG: Clemastine Fumarate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Embolization Treatment of Chronic Refractory Shoulder Tendinopathy
Status: NOT_YET_RECRUITING
Conditions: Shoulder Pain|Tendinopathy|Rotator Cuff Tendinitis|Rotator Cuff Tendinosis|Embolization|Arterial Occlusion
Interventions: DEVICE: Embolization|OTHER: Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FGFR Inhibitor in FGFR Dysregulated Cancer
Status: TERMINATED
Conditions: Lung Cancer|NSCLC|Pulmonary Neoplasm|Squamous Cell Lung Cancer|NSCLC Stage IV
Interventions: DRUG: ERDAFITINIB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of POC Lung Ultrasound Combined With Pressure-volume Curve to Titration Adjust PEEP for ARDS Lung Recruitment
Status: UNKNOWN
Conditions: Acute Respiratory Distress Syndrome
Interventions: DEVICE: Lung Ultrasound|DIAGNOSTIC_TEST: Maximum Oxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic (PK) Study of Homoharringtonine (Omacetaxine Mepesuccinate) Administered Subcutaneously to Patients With Advanced Solid and Hematologic Tumors
Status: COMPLETED
Conditions: Hematologic Tumors
Interventions: DRUG: Omacetaxine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Intrathecal Baclofen (ITB) Bolus on Neuropathic Pain (NP). Preliminary Study.
Status: COMPLETED
Conditions: Neuropathic Pain
Interventions: DRUG: Intrathecal baclofen bolus|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, PK and PD of HNC1058
Status: COMPLETED
Conditions: IPF
Interventions: DRUG: HNC1058 Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Obinutuzumab in Combination With Venetoclax in Previously Untreated Follicular Lymphoma Patients
Status: COMPLETED
Conditions: Follicular Lymphoma
Interventions: DRUG: Obinutuzumab|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: pTVG-HP and Nivolumab in Patients With Non-Metastatic PSA-Recurrent Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: pTVG-HP|DRUG: Nivolumab|DRUG: GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Outpatient Study of Automated Blood Glucose Control With an Insulin-Only Bionic Pancreas
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DEVICE: Fixed set point|DEVICE: Variable set point
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Proof of Concept Study of the Safety, Tolerability, and Efficacy of Avastin (Bevacizumab) in Patients With Chemo-naive Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Lymphocytic Leukemia, Chronic
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Efficacy and Safety of GNS-212-E in Bowel Preparation for Colonoscopy
Status: RECRUITING
Conditions: Colonoscopy|Bowel Preparation
Interventions: DRUG: GNS-212-E1|DRUG: GNS-212-E2|DRUG: GNS-212-ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of NVA237 in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: NVA237 12.5 µg once daily|DRUG: NVA237 25.0 µg once daily|DRUG: NVA237 12.5 µg twice daily|DRUG: NVA237 50.0 µg once daily|DRUG: NVA237 25.0 µg twice daily|DRUG: NVA237 100.0 µg once daily|DRUG: NVA237 50.0 µg twice daily|DRUG: Placebo to NVA237 once daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Rehabilitation Before Lung Cancer Resection
Status: COMPLETED
Conditions: Lung Cancer|COPD|Chronic Obstructive Lung Disease|Emphysema
Interventions: BEHAVIORAL: Mindfulness Based Pulmonary Rehabilitation|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acute Responses of Postural Alignment, Kinematic Synergy, and Intermuscular Coherence to Postural Muscle Facilitation
Status: RECRUITING
Conditions: Posture|Musculoskeletal Equilibrium|Electromyography|Kinematics
Interventions: OTHER: Exercise Then Stretch|OTHER: Stretch Then Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Universal Screening for Vocal Fold Motion Impairment in Children Undergoing Congenital Cardiac Surgery
Status: COMPLETED
Conditions: Vocal Fold Palsy|Dysphagia|Congenital Heart Disease in Children
Interventions: PROCEDURE: Flexible fiberoptic laryngoscopy|PROCEDURE: Laryngeal ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dapsone for Acute Ischemia Stroke Study
Status: UNKNOWN
Conditions: Cerebral Stroke|Cerebrovascular Accident, Acute|Cerebrovascular Stroke|Stroke, Acute|Stroke
Interventions: DRUG: Dapsone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fecal Microbiota Transplantation With Ruxolitinib and Steroids as an Upfront Treatment of Severe Acute Intestinal GVHD
Status: RECRUITING
Conditions: Intestinal GVHD
Interventions: BIOLOGICAL: allogeneic fecal microbiota|DRUG: Ruxolitinib|DRUG: Methylprednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tissue Immune Landscape of Graft Versus Host Disease After Allogeneic Stem Cell Transplantation (TIL-GVHD)
Status: RECRUITING
Conditions: Chronic Graft Versus Host Disease
Interventions: BIOLOGICAL: Additional blood sample|BIOLOGICAL: cGVHD target tissue biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: 3 Months' Versus 6 Months' Anticoagulation in Patients With DVT and/or PE
Status: COMPLETED
Conditions: Deep Vein Thrombosis|Pulmonary Embolism|Deep Vein Thrombosis With Pulmonary Embolism
Interventions: DRUG: Duration of anticoagulation|DRUG: Warfarin duration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot LDE225 in Locally Advanced or Metastatic BCC + Previously Tx Non-LDE225 Smoothened Inhibitors
Status: COMPLETED
Conditions: Basal Cell Carcinoma
Interventions: DRUG: LDE225
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Dose-escalation Study of FF-10832 for Treatment of Solid Tumors Including Biliary Tract Cancer
Status: RECRUITING
Conditions: Advanced Solid Tumors|Biliary Tract Cancer
Interventions: DRUG: FF-10832 Gemcitabine Liposome Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feeding Trial of Bio-fortified Pearl Millet
Status: COMPLETED
Conditions: Iron Deficiency and Anemia
Interventions: OTHER: Iron bio-fortified pearl millet|OTHER: Control pearl millet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase III Randomized Study of the Effect of Postmenopausal Estrogen Replacement Therapy on Alveolar Bone Loss
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: conjugated estrogens|DRUG: Medroxyprogesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of Cilostazol on Plasma Adipocytokine and Arterial Stiffness
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Metabolic Syndrome X
Interventions: DRUG: cilostazol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase Ⅱ Study of F520 in Patients With Cervical Carcinoma
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: DRUG: Recombinant Humanized Anti-PD-1 Monoclonal Antibody Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate The Safety and Efficacy of Balovaptan in Participants With Acute Ischemic Stroke at a High Risk of Developing Malignant Brain Edema
Status: WITHDRAWN
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Balovaptan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of a 96-Hour Continuous Infusion of Paclitaxel Followed by Cisplatin for Patients With Stage III/IV and Relapsed NSCLC
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung|Lung Neoplasms
Interventions: DRUG: paclitaxel|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Treatment of High-Risk Moderate Acute Malnutrition Using Expanded Admission Criteria
Status: COMPLETED
Conditions: Malnutrition
Interventions: DRUG: amoxicillin|DIETARY_SUPPLEMENT: Ready-to-use therapeutic food (RUTF)|BEHAVIORAL: Mother Care group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Diabetic Retinopathy (DR) Without Center Involved-Diabetic Macular Edema (CI-DME)
Status: RECRUITING
Conditions: Diabetic Retinopathy (DR)
Interventions: GENETIC: RGX-314 Dose 1|GENETIC: RGX-314 Dose 2|GENETIC: RGX-314 Dose 3|DRUG: Topical Steroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maintenance Therapy With Toripalimab and Capecitabine Versus Capecitabine Alone in High-risk Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma|High-Risk Cancer|Maintenance Therapy
Interventions: DRUG: Maintenance Therapy with Toripalimab and Capecitabine|DRUG: Maintenance Therapy with Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Assess The Effect Of SB-705498 In A Capsaicin Challenge Model
Status: COMPLETED
Conditions: Rhinitis
Interventions: DRUG: SB-705498|DRUG: Placebo|OTHER: Caspaicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TBTC Study 26 PK: Rifapentine Pharmacokinetics in Children During Treatment of Latent TB Infection
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: Rifapentine + isoniazid once weekly for 3 months
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose Safety, Tolerability and Pharmacokinetics Study of GLYX-13 in Normal Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLYX-13|DRUG: IV normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Electrosurgical Incision Versus Bougie Dilation of Symptomatic Lower Esophageal (Schatzki's) Rings
Status: COMPLETED
Conditions: Lower Esophageal Ring|Dysphagia
Interventions: PROCEDURE: Bougie Dilation|PROCEDURE: Needle-knife incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compatibility and Immunogenicity of a Short Specific Immunotherapy (SIT) in Contrast to Classic Specific Immunotherapy
Status: COMPLETED
Conditions: Immunotherapy
Interventions: BIOLOGICAL: specific subcutaneous immunotherapy house dust mite allergoid (Novo-Helisen Depot)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Stearidonic Acid (SDA) Soybean Oil-containing Foods on Red Blood Cell Fatty Acid Content
Status: COMPLETED
Conditions: Healthy Volunteers|Markers of Cardiovascular Risk
Interventions: OTHER: SDA soybean oil-containing foods|OTHER: High-oleic sunflower oil containing foods|OTHER: Eicosapentaenoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vorapaxar as an Add-On Antiplatelet Therapy in Patients With and Without Diabetes Mellitus
Status: COMPLETED
Conditions: Myocardial Infarction|Diabetes Mellitus|Peripheral Arterial Disease
Interventions: DRUG: Vorapaxar|DRUG: Clopidogrel|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Tolerability of Apevinat BC Compared to Vitamin Complex
Status: UNKNOWN
Conditions: Lack of Appetite|Anorexia
Interventions: DRUG: Apevinat BC|DRUG: Vitamin Complex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zenyth: Motivational Interviewing-based Telehealth Intervention for Bacterial Sexually Transmitted Infection Screening
Status: RECRUITING
Conditions: Sexually Transmitted Diseases|Gonorrhea|Chlamydia|Syphilis|HIV
Interventions: BEHAVIORAL: Motivational interviewing and specimen self-collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of a High-fat Meal on Exercise-mediated Sympatholysis
Status: RECRUITING
Conditions: Diet, Healthy
Interventions: DIETARY_SUPPLEMENT: Beetroot drink|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sipuleucel-T With or Without Tasquinimod in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Hormone-Resistant Prostate Cancer|Metastatic Prostate Carcinoma|Recurrent Prostate Carcinoma|Stage IV Prostate Cancer
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Sipuleucel-T|DRUG: Tasquinimod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficiency of Piezo-Corticision in Accelerating Orthodontic Tooth Movement
Status: UNKNOWN
Conditions: Malocclusion, Angle Class I|Malocclusion; Angle Class II Division 1
Interventions: PROCEDURE: Peizocorticision|PROCEDURE: Conventional Orthodontic Mechanics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: ID Recombinant Ricin Toxin A-Chain Vaccine RVEc™ - 3-Dose Primary Series With Boost
Status: WITHDRAWN
Conditions: Ricin Poisoning
Interventions: BIOLOGICAL: RVEc
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Omega-3 Fatty Acids on Markers of Inflammation
Status: COMPLETED
Conditions: Obesity|Hypertriglyceridemia|Insulin Resistance|Hypertension
Interventions: DIETARY_SUPPLEMENT: Fish Oil|DIETARY_SUPPLEMENT: Flaxseed Oil|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Steroid Dependent Idiopathic Nephrotic Syndrome in Children With Low Doses of Interleukin 2: a Pilot Study
Status: WITHDRAWN
Conditions: Nephrotic Syndrome Steroid-Dependent|Interleukin 2
Interventions: DRUG: IL-2 Low dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heart Rate Variability Biofeedback for Smoking Cessation Treatment
Status: COMPLETED
Conditions: Tobacco Smoking
Interventions: BEHAVIORAL: Cognitive-Behavioral Smoking Cessation|BIOLOGICAL: Heart Rate Variability Biofeedback|DRUG: Nicotine patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oblimersen Sodium & Combination Chemotherapy in Treating Patients With Newly Diagnosed Diffuse Large B-Cell Lymphoma
Status: TERMINATED
Conditions: Contiguous Stage II Adult Diffuse Large Cell Lymphoma|Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma|Stage I Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma
Interventions: BIOLOGICAL: oblimersen sodium|BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: vincristine sulfate|DRUG: prednisone|PROCEDURE: biopsy|GENETIC: microarray analysis|OTHER: immunohistochemistry staining method|GENETIC: gene expression analysis|GENETIC: cytogenetic analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Laryngeal Mask Airway Supreme With the Laryngeal Mask Airway Protector In the Ambulatory Surgery Unit
Status: COMPLETED
Conditions: Airway Complication of Anesthesia
Interventions: DEVICE: Laryngeal mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: TEleRehabilitation Nepal (TERN) to Improve Quality of Life of People With Spinal Cord Injury and Acquired Brain Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries; Traumatic Brain Injury; Acquired Brain Injury, Stroke
Interventions: OTHER: Telerehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Placebo-Controlled Effectiveness in INPH Shunting (PENS) Trial
Status: COMPLETED
Conditions: Idiopathic Normal Pressure Hydrocephalus (INPH)
Interventions: DEVICE: programmable CSF shunt valve
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AZD2171 + Chemotherapy in Advanced NSCLC, Colorectal Cancer, or Other Cancer Suitable for Treatment With Capecitabine (Non-Small Lung Cancer Patients Closed to Enrollment as 8/9/07)
Status: COMPLETED
Conditions: Colorectal Cancer|Lung Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: capecitabine|DRUG: carboplatin|DRUG: cediranib maleate|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Behavior Brain Responses
Status: COMPLETED
Conditions: Alcohol Drinking|Drinking Behavior|Physiological Effects of Drugs|Central Nervous System Depression
Interventions: DRUG: Ethanol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Food Study Metformin Hydrochloride ER Tablets 750 mg and Glucophage XR 750 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Metformin Hydrochloride ER Tablets 750 mg|DRUG: Glucophage XR 750 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Preoperative Prediction Model of Pathological Outcomes (Mesorectum Quality and Positive Circumferential Resection Margin) in Patients With Mid-low Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: PROCEDURE: Transanal total mesorectal excision of rectal cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Topical Capsaicin for Cyclical Vomiting
Status: COMPLETED
Conditions: Cyclical Vomiting
Interventions: DRUG: Capsaicin 0.1% Cream|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Transcranial Direct Current Stimulation on Pain Perception
Status: COMPLETED
Conditions: Pain
Interventions: DEVICE: anodal tDCS|DEVICE: cathodal tDCS|DEVICE: sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Zambia Ivermectin Trial for the Treatment and Prevention of COVID-19
Status: WITHDRAWN
Conditions: SARS-CoV-2|Ivermectin
Interventions: DRUG: Ivermectin|OTHER: Prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)
Status: RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer (mCRPC)|Prostatic Neoplasms
Interventions: DRUG: Opevesostat|DRUG: Dexamethasone|DRUG: Fludrocortisone acetate|DRUG: Hydrocortisone|DRUG: Abiraterone acetate|DRUG: Prednisone acetate|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Gene Transfer Therapy Study to Evaluate the Safety and Efficacy of Delandistrogene Moxeparvovec (SRP-9001) Following Imlifidase Infusion in Participants With Duchenne Muscular Dystrophy (DMD) Determined to Have Pre-existing Antibodies to Recombinant Adeno-Associated Virus Serotype (rAAVrh74)
Status: ENROLLING_BY_INVITATION
Conditions: Duchenne Muscular Dystrophy
Interventions: GENETIC: delandistrogene moxeparvovec|BIOLOGICAL: imlifidase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study to Evaluate Vadadustat for the Correction or Maintenance Treatment of Anemia in Participants With Incident Dialysis-dependent Chronic Kidney Disease (DD-CKD)
Status: COMPLETED
Conditions: Anemia|Dialysis-Dependent Chronic Kidney Disease
Interventions: DRUG: Vadadustat|DRUG: Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Physiotherapy Treatment in Women Suffering From Provoked Vestibulodynia
Status: COMPLETED
Conditions: Vestibulodynia
Interventions: PROCEDURE: Multimodal physiotherapy|DRUG: lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PCOS and US Cavitation
Status: COMPLETED
Conditions: PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
Interventions: OTHER: ultrasound cavitation in addition to aerobic ex|OTHER: aerobic exercises.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Telbivudine in Treatment naïve Patients With Hepatitis B e Antigen (HBeAg)-Positive Chronic Hepatitis B (CHB)
Status: TERMINATED
Conditions: Hepatitis B
Interventions: DRUG: Telbivudine (LdT)|DRUG: peginterferon alpha-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of an Inhaled Sedation Strategy to an Intravenous Sedation Strategy in Intensive Care Unit Patients Treated With Invasive Mechanical Ventilation
Status: RECRUITING
Conditions: Prevention of Delirium
Interventions: DRUG: Propofol + analgesic drug|DRUG: Isoflurane + analgesic drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irinotecan, Oxaliplatin, and Capecitabine as First-Line Therapy in Treating Patients With Metastatic or Unresectable Locally Advanced Small Bowel Cancer
Status: COMPLETED
Conditions: Small Intestine Adenocarcinoma|Recurrent Small Intestine Cancer
Interventions: DRUG: capecitabine|DRUG: irinotecan hydrochloride|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SmartSet HV and Palacos R RSA Bone Cements in Primary Total Hip Arthroplasty
Status: COMPLETED
Conditions: Arthritis
Interventions: DEVICE: Bone cement 1|DEVICE: Bone cement 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilates Exercises v/s Yoga on Rounded Shoulders
Status: COMPLETED
Conditions: Weakness, Muscle|Muscle Tightness|Range of Motion|Pain|Heart Rate|SpO2|Sleep Quality
Interventions: OTHER: Pilates exercises|OTHER: Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Chemotherapy Versus Supportive Therapy In The Treatment Of Unresectable Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Oral|OTHER: Supportive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Hibiscus Sabdariffa in Xerostomia
Status: RECRUITING
Conditions: Radiation-induced Xerostomia
Interventions: BIOLOGICAL: Hibiscus Sabdariffa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of an Experimental Gel Based on Acmella Oleracea Extract in Reducing Post-bleaching Tooth Sensitivity
Status: COMPLETED
Conditions: Tooth Bleaching|Pain|Dentin Desensitizing Agents
Interventions: OTHER: EG (Experimental A. Oleracea extract gel)|OTHER: GP (Gel placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bicalutamide Plus Aromatase Inhibitors in ER(+)/AR(+)/HER2(-) Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Bicalutamide|DRUG: Aromatase Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metabolism and Pharmacokinetics of Primaquine Enantiomers in Human Volunteers Receiving a Seven Day Dose Regimen
Status: COMPLETED
Conditions: Malaria|Glucose 6 Phosphate Dehydrogenase Deficiency
Interventions: DRUG: RPQ|DRUG: SPQ|DRUG: Primaquine Phosphate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dynamic Observational Study With PET of 68Ga-HER2-affibody in Anti-HER2 Treatment
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel combined with Trastuzumab±Pertuzumab|DRUG: T-DM1 or Capecitabine combined with Pyrotinib regimen.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Extension Study Assessing the Safety and Efficacy of AVTX-803 in Subjects With Leukocyte Adhesion Deficiency Type II
Status: RECRUITING
Conditions: Leukocyte Adhesion Deficiency
Interventions: DRUG: AVTX-803
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Therapeutic Effect of Treating Mental Stress Induced Myocardial Ischemia
Status: UNKNOWN
Conditions: Theraphy of Chinese Traditional Medicine
Interventions: DRUG: Xinkeshu tablets|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of Recombinant Human CD4 Immunoglobulin G (rCD4-lgG) in Patients With HIV-Associated Immune Thrombocytopenic Purpura
Status: COMPLETED
Conditions: Immune Thrombocytopenic Purpura ( ITP )|HIV Infections
Interventions: DRUG: CD4-IgG
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver
Status: COMPLETED
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: DRUG: FOLFOX regimen|DRUG: fluorouracil|DRUG: isolated perfusion|DRUG: leucovorin calcium|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Stereotactic Radiotherapy for Oligometastasis (1-5) in Various Tumor Sites vs. Palliative Care
Status: RECRUITING
Conditions: Oligometastatic Disease
Interventions: RADIATION: stereotactic ablative radiation therapy|RADIATION: palliative radiation therapy|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effect of Intraoperative Intravenous S-Ketamine During Total Knee Arthroplasty Surgery
Status: RECRUITING
Conditions: Postoperative Pain, Acute|Anaesthetic
Interventions: DRUG: sodium chloride (NaCl; 0.9%)|DRUG: S-ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Efficacy Study of the Application of Low Level Laser Light to Treat Venous Stasis Ulcers
Status: TERMINATED
Conditions: Venous Stasis Ulcer
Interventions: DEVICE: Erchonia ML Scanner (MLS)|DEVICE: Placebo Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-Invasive Ventilation Versus High-flow Nasal Oxygen in Intensive Care Units
Status: RECRUITING
Conditions: Post Extubation Respiratory Failure
Interventions: PROCEDURE: High-Flow Oxygen|PROCEDURE: Non invasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simvastatin Augmentation of Lithium Treatment in Bipolar Depression
Status: TERMINATED
Conditions: Bipolar Disorder
Interventions: DRUG: Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Effects of ADH-1 Given Daily to Subjects With Solid Tumors
Status: TERMINATED
Conditions: Neoplasms
Interventions: DRUG: ADH -1 (Exherin™)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT