pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Liposomal Cytarabine and Daunorubicin (CPX-351) and Quizartinib for the Treatment of Acute Myeloid Leukemia and High Risk Myelodysplastic Syndrome
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Blasts More Than 10 Percent of Bone Marrow Nucleated Cells|High Risk Myelodysplastic Syndrome|Recurrent Acute Myeloid Leukemia|Recurrent Myelodysplastic Syndrome|Refractory Acute Myeloid Leukemia|Refractory Myelodysplastic Syndrome
Interventions: DRUG: Liposome-encapsulated Daunorubicin-Cytarabine|DRUG: Quizartinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketofol Versus Fenofol as Procedural Sedation for Carpal Tunnel Release
Status: UNKNOWN
Conditions: Procedural Sedation
Interventions: DRUG: propofol-ketamine|DRUG: propofol-fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: REFRaME-O1: A Study to Investigate the Efficacy and Safety of Luveltamab Tazevibulin Versus Investigator's Choice (IC) Chemotherapy in Women With Ovarian Cancer (Including Fallopian Tube or Primary Peritoneal Cancers) Expressing FOLR1
Status: RECRUITING
Conditions: Ovarian Cancer|Epithelial Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Cancer|Platinum-resistant Ovarian Cancer
Interventions: DRUG: Luveltamab tazevibulin|DRUG: Pegfilgrastim|DRUG: Gemcitabine|DRUG: Paclitaxel|DRUG: Pegylated liposomal doxorubicin|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare Remote Patient Management and Standard Care in CRT-D and ICD-patients to Assess the Effect on Heart Failure
Status: COMPLETED
Conditions: Heart Failure|Ventricular Tachycardia|Cardiac Desynchronization
Interventions: BEHAVIORAL: Device triggered remote telephone contact because of Care Alert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Head Positions to Open the Upper Airway
Status: COMPLETED
Conditions: Apnea|Cardiopulmonary Resuscitation
Interventions: PROCEDURE: Extension|PROCEDURE: Neutral head position|PROCEDURE: Anaesthesiologist's position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Bortezomib and Dexamethasone With or Without Elotuzumab to Treat Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: Elotuzumab|DRUG: Bortezomib|DRUG: Dexamethasone|DRUG: Dexamethasone|DRUG: Dexamethasone|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LEVOS - Levofloxacin and Rifampicin Therapy in the Treatment of OsteoArticular Prothethic Infection
Status: TERMINATED
Conditions: Infection
Interventions: DRUG: Levofloxacin (HR355) and Rifampicin Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Find the Maximum Tolerated Dose of the Experimental Combination of the Drugs INC424 and BKM120 in Patients With Primary or Secondary Myelofibrosis
Status: TERMINATED
Conditions: Myelofibrosis
Interventions: DRUG: INC424|DRUG: BKM120
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ATATcH Alternating Treatment Plans for Advanced Cancer
Status: RECRUITING
Conditions: Head and Neck Cancer|Lung Cancer
Interventions: DRUG: Paclitaxel|DRUG: Pemetrexed|DRUG: 5Fluorouracil|DRUG: Carboplatin|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nifedipine GITS and Amlodipine Besylate on Recovery of Blood Pressure Rhythm and Arterial Stiffness
Status: TERMINATED
Conditions: Hypertension
Interventions: DRUG: Nifedipine GITS|DRUG: Amlodipine besylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery
Status: RECRUITING
Conditions: Brain Metastases, Adult|Brain Metastases|Brain Cancer
Interventions: DRUG: 18F fluciclovine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Dose in Healthy Volunteers, Repeat Doses in Asthmatic Patients and of Single Dose in COPD Patients of CHF6366
Status: COMPLETED
Conditions: Asthma|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: CHF6366|DRUG: Placebo CHF6366|DRUG: umeclidinium bromide and vilanterol trifenatate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacological Postconditioning to Reduce Infarct Size Following Primary PCI
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: Exenatide|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spheroidal Mesenchymal Stem Cells in Retinitis Pigmentosa
Status: COMPLETED
Conditions: Retinitis Pigmentosa|Stem Cell Transplant
Interventions: BIOLOGICAL: Stem cell implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Microbiota Directed Food for Children With Severe Acute Malnutrition
Status: NOT_YET_RECRUITING
Conditions: Severe Acute Malnutrition
Interventions: DIETARY_SUPPLEMENT: Microbiota-Directed Food|DIETARY_SUPPLEMENT: Ready-to-Use Therapeutic Food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Feasibility of High-volume, Low-risk Penicillin Allergy De-labelling to Maximise Efficiency in a Resource-limited Setting
Status: NOT_YET_RECRUITING
Conditions: Penicillin Allergy
Interventions: DIAGNOSTIC_TEST: Single dose low-risk penicillin challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Tolerability, and Immunogenicity of V114 in Healthy Infants (V114-029)
Status: COMPLETED
Conditions: Pneumococcal Infections|Pneumococcal Vaccines
Interventions: BIOLOGICAL: V114|BIOLOGICAL: Prevnar 13™|BIOLOGICAL: RotaTeq™|BIOLOGICAL: Pentacel™|BIOLOGICAL: RECOMBIVAX HB™|BIOLOGICAL: VAQTA™|BIOLOGICAL: MMR II™|BIOLOGICAL: VARIVAX™|BIOLOGICAL: HIBERIX™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Modified Herbst Approach to Improve Chin Projection
Status: RECRUITING
Conditions: Class II Malocclusion
Interventions: DEVICE: Modified Herbst Approach|DEVICE: Conventional Herbst Approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study of Metformin HCl 500 mg ER Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Metformin HCl 500 mg tablets, single dose|DRUG: CLUCOPHAGE® XR 500 mg tablets, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy and Safety of Alginos Oral Suspension to Treat Laryngopharyngeal Reflux
Status: COMPLETED
Conditions: Laryngopharyngeal Reflux
Interventions: DRUG: Sodium alginate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability Study of Two Dosing Regimens of CTP-543 in Adults With Alopecia Areata
Status: COMPLETED
Conditions: Alopecia Areata
Interventions: DRUG: CTP-543|DRUG: CTP-543 Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Whey Permeate Study
Status: COMPLETED
Conditions: Malnutrition
Interventions: DIETARY_SUPPLEMENT: Whey permeate RUSF|DIETARY_SUPPLEMENT: Soy Protein RUSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rituxmab Versus IL-6 in Treating ILD
Status: COMPLETED
Conditions: Interstitial Lung Disease|Scleroderma
Interventions: DRUG: Rituximab|DRUG: IL6 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IVIVR Assessing PK Parameters Used to Establish Bioequivalence
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Zyloprim® 300 mg|DRUG: Allopurinol 300 mg; undergranulated, high hardness condition|DRUG: Allopurinol 300 mg; alternative condition 2|DRUG: Allopurinol 300 mg; alternative condition 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of Efficacy,Safety of Combined Deferasirox and Deferiprone Versus Combined Deferiprone and Desferal In Conditions of Iron Overload
Status: UNKNOWN
Conditions: Beta-thalassemia Major|Sickle Cell Disease|Iron Hemosiderosis
Interventions: DRUG: DFP (ferriprox) and deferasirox (ICL 670)|DRUG: DFP, DFO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of a Reusable Multifocal Optical Design in a Presbyopic Population Phase 2
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: senofilcon A Multifocal|DEVICE: senofilcon A Sphere|DEVICE: etafilcon A Multifocal|DEVICE: etafilcon A Sphere
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab Treatment After CYAD-101 With FOLFOX Preconditioning in Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Unresectable Metastatic Colorectal Cancer
Interventions: DRUG: CYAD-101|DRUG: FOLFOX|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of a Gum Health Formulation
Status: COMPLETED
Conditions: Periodontal Diseases|Gingivitis|Periodontitis|Halitosis
Interventions: OTHER: Gingival health formulation in an accelerating device|OTHER: Gingival health formulation on a toothbrush|OTHER: OTC fluoride toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Imaging Study for FdCyd and THU Cancer Treatment
Status: TERMINATED
Conditions: Head and Neck Neoplasms|Lung Neoplasms|Urinary Bladder Neoplasms|Breast Neoplasms
Interventions: DRUG: [F-18]-5-FLUORO-2'-DEOXYCYTIDINE|DRUG: Tetrahydrouridine intravenous (IV)|DRUG: Tetrahydrouridine (oral)|DIAGNOSTIC_TEST: Positron emission tomography (PET)/Computed tomography (CT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Validation of the Two-minute Walk Test and the Ten-meter Walk Test in Individuals With Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: DIAGNOSTIC_TEST: 6-minute walking test|DIAGNOSTIC_TEST: 2-minute walking test|DIAGNOSTIC_TEST: 10-meter walk test|DIAGNOSTIC_TEST: One leg stance test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Aortic Balloon Counterpulastion in Myocardial Infarction Related Shock
Status: COMPLETED
Conditions: Myocardial Infarction|Cardiogenic Shock
Interventions: DEVICE: Intra-aortic balloon pump counterpulsation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRevalence, Persistence and prOgnostic ValuE of Sleep Apnea Syndrome in Acute Heart Failure
Status: COMPLETED
Conditions: Sleep Apnea Syndrome|Heart Failure
Interventions: OTHER: polygraphy and ECG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Application of mRNA Immunotherapy Technology in Epstein-Barr Virus-related Refractory Malignant Tumors
Status: RECRUITING
Conditions: Malignant Tumors
Interventions: BIOLOGICAL: EBV mRNA vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double Arm Pivotal Study to Evaluate the Neurolyser XR for the Treatment of Chronic Low Back Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Facet Syndrome of Lumbar Spine
Interventions: DEVICE: Non-Invasive Thermal Ablation of the Medial Branch Nerves (Neurolyser XR)|OTHER: Sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Monitoring of Hepatic Fat Metabolism Using Magnetic Resonance Methods
Status: COMPLETED
Conditions: Hepatic Fat Content
Interventions: DIETARY_SUPPLEMENT: Fat|DIETARY_SUPPLEMENT: Fasting|DIETARY_SUPPLEMENT: Fat+Glucose|DIETARY_SUPPLEMENT: Glucose|DIETARY_SUPPLEMENT: Fat+Fructose|DIETARY_SUPPLEMENT: Fructose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Trial of Tahitian Noni Juice Safety
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Tahitian Noni Juice|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: The Effect of "Eye Drop Guide" on the Success Rate of Eye Drops Self-instillation in Glaucoma Patients
Status: UNKNOWN
Conditions: Eye Drops Self-instillation
Interventions: DEVICE: Eye Drop Guide technique|BEHAVIORAL: Routine self-instillation technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Acupuncture for Chemotherapy-Induced Peripheral Neuropathy
Status: WITHDRAWN
Conditions: Peripheral Neuropathy
Interventions: OTHER: Manual acupuncture|OTHER: Electro-acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Decitabine Treatment in HPV-Induced Anogenital and Head and Neck Cancer Patients After Radiotherapy or as Novel Late Salvage
Status: TERMINATED
Conditions: Head and Neck Cancer|Anogenital Cancer
Interventions: DRUG: Dacogen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Atorvastatin in Graves' Orbitopathy (GO)
Status: COMPLETED
Conditions: Thyroid Associated Ophthalmopathy|Hypercholesterolemia
Interventions: DRUG: Atorvastatin|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE-OA)
Status: NOT_YET_RECRUITING
Conditions: Obesity|Knee Osteoarthritis|Osteoarthritis, Knee
Interventions: DRUG: Tirzepatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Mental Health Physician Support Program in Nova Scotia
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: OTHER: Mental Health Practice Support Program|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Trial to Evaluate the Effect of Statins on Asthma Control of Patients With Chronic Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Tightly Glucose Control on Hyperglycemic Toxicity and Protein Catabolism in Critically Ill Patients
Status: COMPLETED
Conditions: Critically Ill Patients
Interventions: OTHER: Tightly glucose control|OTHER: Conventional glucose control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 10 mg Donepezil Hydrochloride Orally Disintegrating Tablets Under Non-Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Donepezil Hydrochloride|DRUG: Aricept®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Arterial Base Fluorescence Segmental Positive Staining
Status: COMPLETED
Conditions: Hepatic Carcinoma
Interventions: PROCEDURE: Superselective Intra-arterial Hepatic Injection of Indocyanine Green (ICG) for Fluorescence Image-guided Segmental Positive Staining
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retrospective Analysis of the Epidemiological Change and Determinants of Prognosis of Talaromycosisof Human Immunodeficiency Virus Negative Host in Guangxi
Status: UNKNOWN
Conditions: To Investigate the Characteristics and Prognostic Factors of T. Marneffei Infections and the Causes of Misdiagnosis|To Study the Recurrence Indicators and Establish a Therapeutic Effect Evaluation System of T. Marneffei Infections
Interventions: OTHER: the multiple programs of antifungal therapy for HIV-negative host
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of EE With Vibration Versus Cryotherapy in Rectus Abdomini Muscle Thickness and Inter-recti Distance
Status: COMPLETED
Conditions: Achilles Tendinopathy|Diastasis Recti
Interventions: PROCEDURE: Cryotherapy and eccentric exercise|PROCEDURE: Vibration and eccentric exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adenosine Triphosphate in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Cachexia|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: adenosine triphosphate|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Family Intervention for Teen Drinking in the ER
Status: COMPLETED
Conditions: Alcohol Abuse
Interventions: BEHAVIORAL: Standard Care|BEHAVIORAL: Multidimensional Family Therapy|BEHAVIORAL: Family Motivational Interviewing Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics Combined With Chemotherapy for Patients With Advanced NSCLC
Status: UNKNOWN
Conditions: Probiotics Plus Chemotherapy
Interventions: DRUG: bifico|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Smoking and Periodontal Therapy on Salivary and Gingival Crevicular IL-17 and IL-35
Status: COMPLETED
Conditions: Periodontitis|Periodontal Diseases|Smoking|Smoking, Tobacco
Interventions: PROCEDURE: Non-surgical periodontal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of A Novel Methodology in the Assessment of Urethral Function Using [S,S]-Reboxetine in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: [S,S]-Reboxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Etoricoxib for the Treatment of Muscle Pain and Inflammation Induced by Eccentric Exercise
Status: COMPLETED
Conditions: Muscle Pain
Interventions: DRUG: Etoricoxib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Swallowing Function and Quality of Life in Oropharyngeal Cancer Patients Treated by Chemo-radiotherapy
Status: RECRUITING
Conditions: Oropharyngeal Cancer
Interventions: DEVICE: Percutaneous Endoscopic Gastrotomy tube placement|DRUG: Cisplatin injection|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Split-Face Study Comparing Botox and Jeuveau in Treating Glabellar Lines
Status: ACTIVE_NOT_RECRUITING
Conditions: Glabellar Frown Lines
Interventions: DRUG: PrabotulinumtoxinA|DRUG: Onabotulinum toxin A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pembrolizumab in Combination With Chemotherapy for Head and Neck Cancer
Status: RECRUITING
Conditions: Head and Neck Cancer|Head and Neck Squamous Cell Carcinoma|Head and Neck Neoplasms|Head Cancer|Throat Carcinoma
Interventions: DRUG: Pembrolizumab|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Laser Therapy and LED Therapy on Elderly Individuals With Temporomandibular Disorder
Status: UNKNOWN
Conditions: Laser and LED Therapy on Elderly Individuals With Temporomandibular Disorder
Interventions: RADIATION: Laser Therapy|RADIATION: LED therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Everolimus - Eluting Bioresorbable Vascular Scaffold for Cardiac Allograft Vasculopathy
Status: COMPLETED
Conditions: Cardiac Allograft Vasculopathy
Interventions: DEVICE: Everolimus-Eluting Bioresorbable Vascular Scaffold (ABSORB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharyngeal Electrical Stimulation in Amyotrophic Lateral Sclerosis
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DEVICE: Pharyngeal Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Booster Study of PTX-COVID19-B in Adults Aged 18 Years and Older
Status: UNKNOWN
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: PTX-COVID19-B|BIOLOGICAL: Comirnaty®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Manual Therapy Techniques and Electrotherapy Modalities in Individuals With Non-specific Low Back Pain
Status: COMPLETED
Conditions: Back Pain
Interventions: OTHER: Manual therapy techniques|OTHER: Electrophysical agents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diffusion-weighted MRI to Predict Treatment Response in Stereotactic Radiotherapy of Central Nervous System (CNS) Metastases
Status: UNKNOWN
Conditions: Radiotherapy|Brain Metastases|Sensitivity|Radionecrosis
Interventions: RADIATION: Brain metastases radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetics of LCP-Tacro™ Once Daily and Prograf® Twice A Day in Adult De Novo Liver Transplant Patients
Status: COMPLETED
Conditions: Liver Failure
Interventions: DRUG: LCP -Tacro|DRUG: Prograf
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemia
Status: RECRUITING
Conditions: Cryptococcal Meningitis
Interventions: DRUG: Single dose liposomal Amphotericin and Fluconazole|DRUG: Fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus
Status: COMPLETED
Conditions: Uremic Pruritus|Pruritus
Interventions: DRUG: nalbuphine HCl ER tablets 60 mg BID|DRUG: nalbuphine HCl ER tablets 120mg BID|DRUG: Placebo tablets BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Bevacizumab (Avastin) in Combination With Temozolomide (TMZ) and Radiotherapy in Paediatric and Adolescent Participants With High-Grade Glioma
Status: COMPLETED
Conditions: High Grade Glioma
Interventions: DRUG: Bevacizumab|RADIATION: Radiotherapy|DRUG: Temozolomide (TMZ)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effectiveness of Dynamic Neuromuscular Stabilization Exercises After Lumbar Disc Herniation Surgery
Status: COMPLETED
Conditions: Low Back Pain|Kinesiophobia
Interventions: OTHER: exercise|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Local Wound Infiltration Plus TAP Block Versus Local Wound Infiltration Only
Status: COMPLETED
Conditions: Colorectal Disorders
Interventions: PROCEDURE: Wound infiltration plus TAP|PROCEDURE: Wound infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Application of Omega-3 Polyunsaturated Fatty Acids in Gastric Cancer Patients
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: omega-3 polyunsaturated fatty acids
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Learn About the Effectiveness of Cancer Medicines in Patients With Metastatic Non-small Cell Lung Cancer in Norway.
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: lorlatinib|DRUG: crizotinib|DRUG: brigatinib|DRUG: ceritinib|DRUG: alectinib|DRUG: atezolizumab|DRUG: bevacizumab|DRUG: paclitaxel|DRUG: carboplatin|DRUG: docetaxel|DRUG: erlotinib|DRUG: gefitinib|DRUG: afatinib|DRUG: dacomitinib|DRUG: osimertinib|DRUG: pembrolizumab|DRUG: nivolumab|DRUG: entrectinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mechanical Insufflator-exsufflator in Patients After Video-assisted Thoracoscopic Operations With One-lung Ventilation
Status: RECRUITING
Conditions: Thoracic Diseases
Interventions: DEVICE: Mechanical insufflator-exsufflator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study of Neoadjuvant Treatment of HER2-positive Breast Cancer With Py in Combination With HP
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Pyrotinib Maleate Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Lymphoblastic Leukemia, Acute|Lymphoma, Non-Hodgkin
Interventions: PROCEDURE: R-Blocks|PROCEDURE: Protocol II-Ida
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Toripalimab Plus Platinum-based Doublet for Stage III Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Albumin-bound paclitaxel, Carboplatin, Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incidence And Outcome Of Paracentesis Induced Circulatory Dysfunction In Acute-On-Chronic Liver Failure.
Status: COMPLETED
Conditions: Acute on Chronic Liver Failure
Interventions: DRUG: Albumin|DRUG: Ascitic fluid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Laparoscopic Hepatectomy Versus RFA in the Treatment of Recurrent HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma Recurrent
Interventions: PROCEDURE: Laparoscopic Hepatectomy|PROCEDURE: Radiofrequency Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Omega 3 and Fibre Intervention Study to Improve Metabolic Health
Status: UNKNOWN
Conditions: Metabolic Disease|Immune Function|Cardiovascular Diseases|Systemic Inflammation
Interventions: DIETARY_SUPPLEMENT: Omega 3 fatty acid|DIETARY_SUPPLEMENT: Inulin fibre
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Global Phase1 Study to Assess the Safety and Tolerability of AZD1208 in Advanced Solid Tumors and Malignant Lymphoma
Status: COMPLETED
Conditions: Advanced Solid Malignancies|Malignant Lymphoma
Interventions: DRUG: AZD1208
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Effects of Intrathecal Hyperbaric Prilocaine or Bupivacaine in Surgery Under Spinal Anesthesia
Status: RECRUITING
Conditions: Spinal Anesthesia|Cardiac Toxicity
Interventions: DRUG: Hyperbaric bupivacaïne|DRUG: Hyperbaric prilocaïne
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Bortezomib and Dexamethasone as Treatment and Maintenance for Multiple Myeloma Relapse
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sofosbuvir (GS-7977) in Combination With PEG and Ribavirin for 12 Weeks in Treatment Experienced Subjects With Chronic HCV Infection Genotype 2 or 3
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: SOF|DRUG: PEG|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of isoQUercetin and Aspirin on Platelet Function
Status: WITHDRAWN
Conditions: Cardiovascular Disease
Interventions: DRUG: Vehicle control|DRUG: Isoquercetin|DRUG: Aspirin|DRUG: Isoquercetin plus Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Open-Label, Dose-Escalation Study of Pemigatinib in Subjects With Advanced Malignancies - (FIGHT-101)
Status: TERMINATED
Conditions: Lung Cancer|Solid Tumor|Gastric Cancer|Urothelial Cancer|Endometrial Cancer|Multiple Myeloma|Myeloproliferative Neoplasms|Breast Cancer|Cholangiocarcinoma|UC|MPN
Interventions: DRUG: Pemigatinib|DRUG: Gemcitabine|DRUG: Pembrolizumab|DRUG: Docetaxel|DRUG: Trastuzumab|DRUG: Retifanlimab|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: JMT101 in Combination With Osimertinib, Versus Cisplatin-pemetrexed in Participants With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Characterized by Epithermal Growth Factor Receptor (EGFR) Exon 20ins Mutations
Status: NOT_YET_RECRUITING
Conditions: Local Advanced or Metastatic NSCLC
Interventions: DRUG: JMT101 Injection|DRUG: Osimertinib tablet|DRUG: Cisplatin injection|DRUG: Pemetrexed injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral Febuxostat in Participants With Gout
Status: COMPLETED
Conditions: Gout
Interventions: DRUG: Febuxostat|DRUG: Febuxostat|DRUG: Allopurinol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Durability of Two Skin Barrier Protectants (SBP)
Status: COMPLETED
Conditions: Skin Hydration in Healthy Volunteers
Interventions: DEVICE: Marathon® XL No Sting Cyanoacrylate Skin Protectant and 3M™ Cavilon™ Advanced Skin Protectant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Insulin Aspart vs. Insulin Lispro vs. Regular Insulin in Paediatric Population
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin human|DRUG: insulin lispro|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autonomic Effects of Spinal Cord Stimulation in Spinal Cord Injury
Status: RECRUITING
Conditions: Orthostatic Hypotension
Interventions: OTHER: Transcutaneous Spinal Cord Stimulation (TSCS)|OTHER: Sham Transcutaneous Spinal Cord Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Early Versus Delayed Enteral Feeding to Treat People With Acute Lung Injury or Acute Respiratory Distress Syndrome (The EDEN Study)
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Adult
Interventions: BEHAVIORAL: Minimal (Trophic) Feeding|BEHAVIORAL: Full Feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shoulder iD™ Primary Reversed Glenoid Outcomes Clinical Study
Status: RECRUITING
Conditions: Rotator Cuff Tears|Rheumatoid Arthritis Shoulder|Osteoarthritis Shoulder|Avascular Necrosis of the Head of Humerus|Fracture, Humeral|Traumatic Arthritis of Right Shoulder Region (Diagnosis)|Shoulder Deformity
Interventions: DEVICE: Shoulder iD™ Primary Reversed Glenoid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Observation of the Efficacy of Different Vitrectomy Systems to Treat Proliferative Diabetic Retinopathy
Status: COMPLETED
Conditions: Proliferative Diabetic Retinopathy|Vitrectomy
Interventions: DEVICE: beveled 27G+ vitrectomy system|DEVICE: standard 25G+ vitrectomy system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weight Management in Rural Communities
Status: COMPLETED
Conditions: Weight Loss|Obesity|Body Weight
Interventions: DIETARY_SUPPLEMENT: Portion Controlled Meals (PCM)|BEHAVIORAL: Group Phone (GP)|DIETARY_SUPPLEMENT: Conventional Diet|BEHAVIORAL: Individual Phone (IP)|BEHAVIORAL: Enhanced Usual Care (EUC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Response-adapted Intensification of Induction Chemotherapy in Patients With Newly Diagnosed Multiple Myeloma (MM)
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Thalidomide, cyclophosphamide, dexamethasone, bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Outcome of Infraumbilical Versus a Modified Intraumbilical Direct Trocar Insertion
Status: UNKNOWN
Conditions: Gynecologic Disease
Interventions: PROCEDURE: infraumbilical transverse incision|PROCEDURE: intraumbilical incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effects of Dietary Supplement of Coenzyme Q10（CoQ10） on Dyslipidemia
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DIETARY_SUPPLEMENT: coenzyme Q10 vitamin E softgel|DIETARY_SUPPLEMENT: coenzyme Q10 softgel|DIETARY_SUPPLEMENT: placebo softgel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LDR vs. HDR Brachytherapy for Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: Low dose rate prostate brachytherapy|RADIATION: High dose rate prostate brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selective COX-II Inhibitor as a Palliative Therapy in Patients With R1 or R2 Resection for Disseminated Stomach Cancer - A Multi-Centre Prospective Randomized Controlled Trial
Status: UNKNOWN
Conditions: Cancer of Stomach
Interventions: DRUG: Vioxx (Rofecoxib)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Tolerability of Repeated Doses of an Investigational New Drug in Patients With Cancer and Cachexia.
Status: COMPLETED
Conditions: Cachexia|Non-Small-Cell Lung Cancer|Pancreatic Cancer|Colorectal Cancer
Interventions: DRUG: PF-06946860
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Pharyngeal High Resolution Manometry and Impedance in Swallow Function of Head and Neck Cancer Patients
Status: WITHDRAWN
Conditions: Head and Neck Cancer|Dysphagia
Interventions: DIAGNOSTIC_TEST: pHRMi
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of OPA-15406 Ointment in Patients With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: OPA-15406|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy and Safety of Selinexor (KPT-330) in Participants With Recurrent Gliomas
Status: TERMINATED
Conditions: Glioblastoma|Glioma
Interventions: DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propofol for Supreme LMA Insertion With and Without Remifentanil
Status: COMPLETED
Conditions: Patients Requiring Ambulatory Surgery Under General Anesthesia
Interventions: DRUG: propofol|DRUG: propofol and remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Cognitive Stimulation and Chemobrain. An Innovative Intervention for Cancer Survivors
Status: UNKNOWN
Conditions: Breast Cancer|Cognitive Decline
Interventions: OTHER: Personalized cognitive stimulation|OTHER: Sham cognitive stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Reactogenicity of DPX-RSV(A), a Respiratory Syncytial Virus Vaccine
Status: COMPLETED
Conditions: Respiratory Syncytial Virus
Interventions: BIOLOGICAL: DPX-RSV(A)|BIOLOGICAL: RSV(A)-Alum|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: FNB in ACL Recon Under GA
Status: NOT_YET_RECRUITING
Conditions: Anterior Cruciate Ligament Rupture|Femoral Nerve Block
Interventions: PROCEDURE: Sono-guided injection|DRUG: Ropivacaine injection|DRUG: Saline injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cooled Radiofrequency vs. Hyaluronic Acid to Manage Knee Pain
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DEVICE: Cooled Radiofrequency|OTHER: Hyaluronic Acid Injection|OTHER: Crossover from Hyaluronic Acid Injection to Cooled Radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Multimodal Care for Cystectomy Frail Patient
Status: TERMINATED
Conditions: Frail Elderly Syndrome|Bladder Disease|Nutrition Disorders|Cognitive Symptom
Interventions: DIETARY_SUPPLEMENT: oral whey protein|DIETARY_SUPPLEMENT: Immunonutrition|DIETARY_SUPPLEMENT: Carbohydrate Drink|OTHER: Preoperative hydration|OTHER: continous spinal anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Minimally Invasive or Conventional Edge-To-Edge Repair for Severe Mitral Regurgitation Due to Bileaflet Prolapse in Barlow's Disease: Does the Surgical Approach Have an Impact on the Long-term Results?
Status: COMPLETED
Conditions: Barlow's Disease|Prolapse; Mitral
Interventions: PROCEDURE: Right minithoracotomy|PROCEDURE: Sternotomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Parent-Mediated Intervention for Families With Children With Autism and Feeding Challenges, Australia Cohort
Status: COMPLETED
Conditions: Parent-Child Relations|Meals|Autism Spectrum Disorder
Interventions: BEHAVIORAL: Parent-Mediated Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Irinotecan Hydrochloride Liposome in Combination With 5-FU/LV in Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: Irinotecan liposome、5-fluorouracil、Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of CBASP for Individuals With Co-occurring Chronic Depression and Alcohol Dependence
Status: COMPLETED
Conditions: Depressive Disorder|Major Depressive Disorder|Dysthymic Disorder|Alcohol-Related Disorders|Alcoholism
Interventions: BEHAVIORAL: Cognitive Behavioral Analysis System of Psychotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Triapine in Combination With Temozolomide for the Treatment of Patients With Recurrent Glioblastoma
Status: RECRUITING
Conditions: Recurrent Glioblastoma, IDH-Wildtype|Recurrent WHO Grade 2 Glioma|Recurrent WHO Grade 3 Glioma|Recurrent WHO Grade 4 Glioma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Magnetic Resonance Imaging|OTHER: Questionnaire Administration|PROCEDURE: Resection|DRUG: Temozolomide|DRUG: Triapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 24-hr Intraocular Pressure Control With SIMBRINZA ®
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Brinzolamide 1%/brimonidine 0.2% tartrate ophthalmic suspension|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Liraglutide on IVF in Obese PCOS
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Obesity|Infertility, Female
Interventions: DRUG: MET|DRUG: COMBI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies
Status: RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|RAS Mutation|Lung Cancer|Colon Cancer|Glioblastoma|Pancreatic Cancer
Interventions: DRUG: RSC-1255 Dose Escalation|DRUG: RSC-1255 Dose Expansion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Traumatic Brain Injury
Status: COMPLETED
Conditions: Brain Injuries|Craniocerebral Trauma|Trauma, Nervous System|Traumatic Brain Injury
Interventions: DRUG: IV Propranolol and Per Tube Clonidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT