pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluation of Non-Invasive Continuous vs Intermittent BloodPressure Monitors in Maintenance Dialysis (BP Dialysis)
Status: COMPLETED
Conditions: End Stage Renal Disease|End Stage Renal Disease on Dialysis|Dialysis Hypotension|Dialysis Induced Hypertension
Interventions: DEVICE: Intermittent Non-InvasiveBlood Pressure Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of the Efficacy and Safety of Rituximab in Participants With Systemic Sclerosis
Status: COMPLETED
Conditions: Scleroderma, Systemic|Skin Sclerosis|Lung Fibrosis|Autoimmune Diseases|Collagen Diseases
Interventions: DRUG: Double-Blind Placebo|DRUG: Double-Blind Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Clopidogrel on Coated-Platelets in Patients Undergoing Cardiac Catheterization
Status: COMPLETED
Conditions: Coronary Artery Disease|Chest Pain
Interventions: DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intra-subject Variability Following Administrations of Activated Recombinant Human Factor VII in Haemophilia Patients in a Non-bleeding State
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A|Haemophilia B
Interventions: DRUG: activated recombinant human factor VII
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sulfasalazine and Stereotactic Radiosurgery for Recurrent Glioblastoma
Status: COMPLETED
Conditions: Glioma|Glioblastoma|Recurrent Glioblastoma
Interventions: DRUG: Sulfasalazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Right Ventricular Hemodynamics Using Cardiac MRI in Patients COPD and OSA
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Chronic Obstructive Pulmonary Disease|Overlap Syndrome
Interventions: DEVICE: Bi-level positive airway pressure (BPAP)|DRUG: Nocturnal oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Myofacial Release vs. Eccentric Resistance on Pain, ROM and Functional Disability on Achilles Tendonitis
Status: COMPLETED
Conditions: Achilles Tendonitis
Interventions: OTHER: eccentric resistance exercise|OTHER: myofascial release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Caesarean Section
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Tranexamic acid injection|OTHER: Normal saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Safety, Tolerability and Pharmacokinetics of ABBV-368 as a Single Agent and Combination in Subjects With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors Cancer
Interventions: DRUG: ABBV-368|DRUG: ABBV-181
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Efficacy and Safety of Prospekta in the Treatment of Attention Deficit/Hyperactivity Disorder in Children
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Prospekta|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept Study of AX-158 in Patients With Mild to Moderate Plaque Psoriasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Psoriasis|Plaque Psoriasis
Interventions: DRUG: AX-158|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Zambia Healthy Choices Project for Emerging Adults Living With HIV
Status: RECRUITING
Conditions: Pre-Exposure Prophylaxis
Interventions: BEHAVIORAL: Mobile Healthy Choices (mHC)|BEHAVIORAL: Motivational Text Messaging (MTM)|BEHAVIORAL: Standard ART Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Xia Shi Surgical Treatment for Eczema Multi-center Clinical Research
Status: UNKNOWN
Conditions: Eczema
Interventions: DRUG: Furoic acid loperamide hydrochloride cream|DRUG: Mullite ointment|DRUG: 3% boric acid solution|DRUG: Zine oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tobramycin Inhalation Powder From a Modified Manufacturing Process Versus Placebo
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Tobramycin Inhalation Powder|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MPDL3280A With Chemoradiation for Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer|Non-Small Cell Lung Cancer
Interventions: DRUG: MPDL3280A|DRUG: Carboplatin|DRUG: Paclitaxel|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrated Patient Avatars for Guiding Systemic Therapy Treatments in Metastatic Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Cancer|Breast Neoplasms|Metastatic Breast Cancer|Cancer, Breast
Interventions: DIAGNOSTIC_TEST: Needle Core Biopsies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of TAS-102 in Patients With Metastatic Colorectal Cancer Refractory to Standard Chemotherapies
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: TAS-102|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TITLE:Less Intensive Therapy for Children With Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: filgrastim|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: methotrexate|DRUG: prednisolone|DRUG: prednisone|DRUG: therapeutic hydrocortisone|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Validation of the GenePOC GBS Assay for the Detection of the Cfb Gene From Streptococcus Agalactiae Strains
Status: COMPLETED
Conditions: Streptococcus Agalactiae Infection
Interventions: DEVICE: Comparison between GenePOC PCR and Reference Method
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation Of The Total Face Mask For Emergency Application In Acute Respiratory Failure
Status: COMPLETED
Conditions: Acute Respiratory Insufficiency
Interventions: DEVICE: Total face mask (interface for NPPV)|DEVICE: Comfort full or RT040 oronasal mask (interface for NPPV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repeat Dose Study of Controlled-Release Paroxetine Tablets and Immediate-Release Paroxetine Tablets in Healthy Japanese Male Subjects
Status: COMPLETED
Conditions: Depressive Disorder
Interventions: DRUG: Paroxetine CR and Paroxetine IR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Rituximab and Pembrolizumab With or Without Lenalidomide in Treating Patients With Relapsed Follicular Lymphoma and Diffuse Large B-Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Diffuse Large B-Cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3a Follicular Lymphoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Lenalidomide|BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sodium Bicarbonate Supplementation in Athletes
Status: COMPLETED
Conditions: Supplementation|Sport
Interventions: DIETARY_SUPPLEMENT: Sodium bicarbonate supplementation|DIETARY_SUPPLEMENT: Placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Personalized Anti-PD-1 and Anti-VEGFR Therapy in OSCC Patients
Status: RECRUITING
Conditions: Oral Squamous Cell Carcinoma|Neoadjvant Therapy|Anti-PD-1|Anti-VEGFR
Interventions: DRUG: Camrelizumab (anti-PD-1 inhibitor)|DRUG: Apatinib (anti-VEGFR inhibitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis
Status: UNKNOWN
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: glucosamine sulphate|DRUG: ibuprofen|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Comparison of the Immunogenicity and Safety of Quinvaxem in Mono-dose Vials and Uniject
Status: COMPLETED
Conditions: Diphtheria|Pertussis|Tetanus|Hepatitis B|Haemophilus Infections
Interventions: BIOLOGICAL: Quinvaxem in Uniject|BIOLOGICAL: Quinvaxem in single dose vials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Therapy in Clinical Stage I-III HER2-positive Breast Cancer.
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: paclitaxel|DRUG: Trastuzumab|DRUG: Pertuzumab|DRUG: carboplatin|PROCEDURE: Breast surgery|DRUG: AC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Acetaminophen and N-Acetylcysteine on Liver Metabolism on Homocystinuria
Status: SUSPENDED
Conditions: CBS Deficiency
Interventions: DRUG: Acetaminophen|DRUG: N-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Optimal Dose of Surfactant for Preterm Infants With Respiratory Distress Syndrome
Status: RECRUITING
Conditions: Respiratory Distress Syndrome, Newborn|Patent Ductus Arteriosus|Bronchopulmonary Dysplasia|Preterm
Interventions: DRUG: PS is stopped when the pressure is equal between bPDA and aPDA.|DRUG: PS is given according to the 2019 European RDS management guideline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GlucoCEST MRI in Oncology
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma|Lymphoma|Glioma
Interventions: OTHER: Glucose infusion|DIAGNOSTIC_TEST: Magnetic Resonance Imaging (MRI)|DIAGNOSTIC_TEST: FDG PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vorinostat Before Surgery in Treating Patients With Triple-Negative Breast Cancer
Status: WITHDRAWN
Conditions: Stage II Breast Cancer|Stage IIIA Breast Cancer|Triple-negative Breast Cancer
Interventions: DRUG: vorinostat|PROCEDURE: therapeutic conventional surgery|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Inhaled Insulin in Type 1 Diabetes
Status: TERMINATED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: inhaled human insulin|DRUG: insulin detemir|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insulin Glulisine in Adult Subjects With Type 2 Diabetes Receiving Insulin Glargine as Basal Insulin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: insulin glulisine|DRUG: insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: THE VALUE OF INTERLEUKIN 6 AS A DIAGNOSTIC MARKER IN NEONATAL SEPSIS
Status: NOT_YET_RECRUITING
Conditions: NEONATAL SEPSIS
Interventions: DIAGNOSTIC_TEST: INTERLEUKIN 6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Feasibility of Hypertonic Saline Solution After Aneurysmal Subarachnoid Hemorrhage:
Status: UNKNOWN
Conditions: Subarachnoid Hemorrhage|Cerebral Vasospasm|Hyponatremia
Interventions: DRUG: HTS 3%|DRUG: Standard fluid management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Trial of ABT-888 in Combination With Temozolomide Versus Pegylated Liposomal Doxorubicin Alone in Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: ABT-888|DRUG: pegylated liposomal doxorubicin|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "LANK-2": Activated and Expanded NK Cell Immunotherapy Together With Salvage Chemotherapy in Children, Adolescents and Young Adults With Relapsed or Refractary Acute Leukemia
Status: COMPLETED
Conditions: Relapsed/Refractory Paediatric Acute Leukaemia
Interventions: BIOLOGICAL: Activated and expanded natural killer cells (NKAEs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Morphine for Unilateral Total Knee Arthroplasty
Status: COMPLETED
Conditions: Primary Osteoarthritis of Knee Nos
Interventions: PROCEDURE: 50 ug IT morphine|PROCEDURE: 100 ug IT morphine|PROCEDURE: No IT morphine|DRUG: Morphine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of JNJ-64565111 on Cardiac Repolarization (Corrected QT Interval) Compared With Placebo in Healthy Adults: a Thorough ECG Study Employing Placebo, JNJ-64565111, and a Positive Control (Moxifloxacin)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-64565111|DRUG: Moxifloxacin|DRUG: JNJ-64565111-matching Placebo|DRUG: Moxifloxacin-matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Porcine Fibrin Sealant in Preventing Cervical Anastomotic Leakage (PLACE030)
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Anastomotic Leak
Interventions: BIOLOGICAL: Porcine Fibrin Sealant (PFS)|PROCEDURE: McKeown esophagectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Montelukast on Atopic Dermatitis in Koreans
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Montelukast first, then placebo|DRUG: Placebo first, then Montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Fixed Brinzolamide-brimonidine Combination on Intraocular Pressure After Phacoemulsification
Status: COMPLETED
Conditions: Cataract|Intraocular Pressure
Interventions: DRUG: Brinzolamide-Brimonidine fixed combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ACHIEVE Brain Health Follow-Up Study
Status: ENROLLING_BY_INVITATION
Conditions: Aging|Cognitive Decline|Mild Cognitive Impairment|Dementia|Hearing Loss
Interventions: OTHER: Hearing intervention|OTHER: Successful aging/delayed hearing intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Exercise Training in Patients With Atrial Fibrillation and Sleep Apnea: A Pilot Study
Status: COMPLETED
Conditions: Sleep Deprivation
Interventions: BEHAVIORAL: Moderate intensity interval training (MITT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Sequential Multiple Assignment Treatment for Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar I Disorder|Bipolar II Disorder
Interventions: DRUG: Lithium|DRUG: Divalproex|DRUG: Lamotrigine|DRUG: Quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fenretinide/LXS Oral Powder Plus Ketoconazole in Recurrent Ovarian Cancer
Status: TERMINATED
Conditions: Ovarian Cancer|Cancer of Ovary|Cancer of the Ovary|Ovary Neoplasms|Primary Peritoneal Carcinoma
Interventions: DRUG: Fenretinide/LXS + Ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PC-Trial: Patent Foramen Ovale and Cryptogenic Embolism
Status: UNKNOWN
Conditions: Embolism, Paradoxical|Heart Septal Defects, Atrial
Interventions: DEVICE: Percutaneous closure of patent foramen ovale|DRUG: Medical antitrhombotic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Liver Function After Intravenous Methylprednisolone Administration
Status: COMPLETED
Conditions: Graves Disease|Graves Ophthalmopathy|Liver Diseases|Liver Failure|Liver Injury|Liver Dysfunction|Liver Insufficiency|Acute Liver Failure|Acute Liver Injury|Acute Liver Injury, Drug Induced|Methylprednisolone Adverse Reaction|Glucocorticoids Toxicity|Dysthyroid Orbitopathy|Dysthyroid Ophthalmopathy
Interventions: DRUG: every week IVMP therapy|DRUG: very high doses IVMP therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Journey Study: Evaluate the Efficacy, Safety, and Tolerability of Valbenazine as Adjunctive Treatment for Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: Placebo|DRUG: Valbenazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Wave Therapy for Post-stenotic Microvascular Remodeling
Status: WITHDRAWN
Conditions: Renal Artery Stenosis
Interventions: DEVICE: Low-energy extracorporeal ultrasound shockwave therapy (SWT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Dual-task Exercises on Gait Parameters and Cognitive Function in Elderly Women: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: dual -task exercises|OTHER: Aerobic training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 24-hr Intraocular Pressure Control With Dorzolamide/Timolol vs the Brimonidine/Timolol Fixed Combination
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: treatment with dorzolamide/timolol|DRUG: treatment with brimonidine/timolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Building a Renewed ImaGe After Head & Neck Cancer Treatment (BRIGHT) Multi-Site RCT
Status: RECRUITING
Conditions: Head and Neck Cancer|Body Image Disturbance|Body Image|Survivorship|Psychosocial Impairment|Mental Health Issue
Interventions: BEHAVIORAL: BRIGHT|BEHAVIORAL: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: External Oblique Intercostal Plane Block Versus Subcostal Transversus Abdominis Plane Block in Supra-umbilical Surgical Incisions
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: PROCEDURE: external oblique intercostal plain block (EOIP)|PROCEDURE: subcostal transversus abdominis plane block (SCTAP)|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Assess the Efficacy and Safety of Olaparib in Chinese Patients With Metastatic Castration-Resistant Prostate Cancer Who Have Failed Prior Treatment With a New Hormonal Agent and Have BRCA1/2 Mutations
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: olaparib|DRUG: enzalutamide|DRUG: abiraterone acetate|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ME-WEL: eHealth Behaviour Change Intervention for Weight Management in Post-menopausal Women
Status: COMPLETED
Conditions: Subjective Well-being|Weight Loss|Self Esteem|Physical Activity|Eating Behavior|Behavior and Behavior Mechanisms
Interventions: BEHAVIORAL: Control Group: Delivery of a health literacy flyer|BEHAVIORAL: Experimental Group: Weekly group sessions for weight management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Drug-drug Interaction and Food-effect Study With GLPG4716 and Midazolam in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG4716|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Carboplatin, Paclitaxel, Cetuximab, and Erlotinib Hydrochloride in Treating Patients With Metastatic or Recurrent Head and Neck Squamous Cell Cancer
Status: COMPLETED
Conditions: Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma|Recurrent Metastatic Squamous Neck Cancer With Occult Primary|Recurrent Salivary Gland Cancer|Recurrent Squamous Cell Carcinoma of the Hypopharynx|Recurrent Squamous Cell Carcinoma of the Larynx|Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity|Recurrent Squamous Cell Carcinoma of the Nasopharynx|Recurrent Squamous Cell Carcinoma of the Oropharynx|Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Recurrent Verrucous Carcinoma of the Larynx|Recurrent Verrucous Carcinoma of the Oral Cavity|Salivary Gland Squamous Cell Carcinoma|Stage IV Salivary Gland Cancer|Stage IV Squamous Cell Carcinoma of the Hypopharynx|Stage IV Squamous Cell Carcinoma of the Larynx|Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IV Squamous Cell Carcinoma of the Nasopharynx|Stage IV Squamous Cell Carcinoma of the Oropharynx|Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IV Verrucous Carcinoma of the Larynx|Stage IV Verrucous Carcinoma of the Oral Cavity|Tongue Cancer|Untreated Metastatic Squamous Neck Cancer With Occult Primary
Interventions: BIOLOGICAL: cetuximab|DRUG: paclitaxel|DRUG: carboplatin|DRUG: erlotinib hydrochloride|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interleukin-2 Plus Activated White Blood Cells in Treating Patients With Cancer That Has Not Responded to Chemotherapy or Radiation Therapy
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: therapeutic autologous lymphocytes|BIOLOGICAL: therapeutic tumor infiltrating lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy And Safety Of Tofacitinib In Chinese Subjects With Active Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Tofacitinib|OTHER: Placebo|DRUG: Tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of N-acetylcysteine (NAC) on Hydrogen Sulfide (H2S) in Chronic Kidney Disease (CKD)
Status: COMPLETED
Conditions: Chronic Kidney Disease|Chronic Kidney Failure|End Stage Kidney Disease|End Stage Renal Disease
Interventions: DRUG: N-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of an Implantable Device for Lowering Intraocular Pressure in Glaucoma Patients Undergoing Cataract Surgery
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma (POAG)|Cataract
Interventions: PROCEDURE: Cataract Surgery|DEVICE: CyPass Micro-Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: 177Lu-PP-F11N in Combination With Sacubitril for Receptor Targeted Therapy and Imaging of Metastatic Thyroid Cancer
Status: COMPLETED
Conditions: Thyroid Cancer, Medullary
Interventions: DRUG: 177Lu-PP-F11N|DRUG: Sacuitril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Iguratimod in Patients With Hand Osteoarthritis (ESIGO)
Status: NOT_YET_RECRUITING
Conditions: Hand Osteoarthritis|Inflammatory Arthritis
Interventions: DRUG: Iguratimod|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Sugammadex for the Reversal of Neuromuscular Blockade in American Society of Anesthesiologists (ASA) Class 3 or 4 Participants (MK-8616-145)
Status: COMPLETED
Conditions: Reversal of Neuromuscular Blockade
Interventions: DRUG: Sugammadex 2 mg/kg|DRUG: Sugammadex 4 mg/kg|DRUG: Sugammadex 16 mg/kg|DRUG: Neostigmine + Glycopyrrolate|DRUG: Rocuronium|DRUG: Vecuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lidocaine Patch in Treating Cancer Patients With Neuropathic Pain After Surgery
Status: COMPLETED
Conditions: Pain|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: lidocaine|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Neuromuscular and Vestibulo-Ocular Training on Balance,Isokinetic Strength and Proprioception in Chronic Ankle Instability
Status: COMPLETED
Conditions: Chronic Ankle Instability
Interventions: OTHER: exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Nocturnal Nasal Oxygen on Biomarkers in Sleep Apnea Patients With Heart Failure
Status: TERMINATED
Conditions: Sleep Apnea|Heart Failure
Interventions: PROCEDURE: Nocturnal nasal oxygen|OTHER: No nasal oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Pain Management Following Laparoscopic Cholecystectomy RCT
Status: COMPLETED
Conditions: Acute Post-operative Pain|Cholecystectomy, Laparoscopic|Pain Assessment Pain Intensity|Pain Intensity
Interventions: PROCEDURE: active gas aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Crossover Bioavailability Clinical Trial of Parenteral Pyronaridine and Artesunate
Status: NOT_YET_RECRUITING
Conditions: Severe Malarial Treatment
Interventions: DRUG: artesunate-pyronaridine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Analgesic Efficacy of Bilateral Superficial Cervical Plexus Block in Robot-assisted Endoscopic Thyroidectomy Using a Transaxillary Approach
Status: COMPLETED
Conditions: Thyroid Cancer
Interventions: PROCEDURE: Bilateral superficial cervical plexus block|PROCEDURE: placebo|PROCEDURE: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Pharmacokinetics and Safety of GSK2336805 in Subjects With Hepatic Impairment and Healthy Matched Control Subjects
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: GSK2336805
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selective Enamel Etching in Self-etching Adhesives: a 2-year Clinical Trial
Status: COMPLETED
Conditions: Selective Enamel Etching in Dental Restorations
Interventions: DRUG: Selective enamel etching with 36% phosphoric acid|DRUG: No selective enamel etching with 36% phosphoric acid|DEVICE: Clearfil SE Bond|DEVICE: Xeno V
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mirvetuximab Soravtansine (IMGN853) and Bevacizumab in Patients With Endometrial Cancer
Status: WITHDRAWN
Conditions: Endometrial Cancer|Endometrial Adenocarcinoma|Endometrial Serous Adenocarcinoma|Endometrial Clear Cell Adenocarcinoma
Interventions: DRUG: Mirvetuximab Soravtansine|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two New Generation Drug Eluting Stents in Patients With Diabetes (OCT-DES)
Status: COMPLETED
Conditions: Coronary Artery Disease|Diabetes
Interventions: DEVICE: Optical coherence tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Heparin Versus no Heparin on Duration of Peripherally Inserted Central Catheter (PICC) Patency in Neonates
Status: WITHDRAWN
Conditions: Infant, Premature|Anticoagulants|Thrombosis
Interventions: DRUG: heparin|DRUG: No heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of ESPB on Intraoperative Remifentanil Consumption
Status: RECRUITING
Conditions: Lumbar Spine Surgery|Erector Spinae Plane Block|Remifentanil Consumption
Interventions: DRUG: Preoperative Erector Spinae Plane Block|DRUG: Postoperative Erector Spinae Plane Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of a New Pediatric Arm Rehabilitation Robot ChARMin
Status: UNKNOWN
Conditions: Nervous System Diseases
Interventions: DEVICE: ChARMin|DEVICE: ChARMin|DEVICE: ChARMin|DEVICE: ChARMin|DEVICE: ChARMin|DEVICE: ChARMin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Atorvastatin for the Treatment of Retinal Vein Occlusion
Status: UNKNOWN
Conditions: Retinal Vein Occlusion|Retinal Vein Thrombosis|Central Retinal Vein Occlusion|Branch Retinal Vein Occlusion|Thrombosis
Interventions: DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decortication With Calcium Phosphosilicate Putty in the Treatment of Non-contained Intrabony Periodontal Defects
Status: UNKNOWN
Conditions: Periodontal Bone Loss
Interventions: PROCEDURE: OFD+IMP+CPS|PROCEDURE: OFD+IMP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Large-scale Research for Immunotherapy of Glioblastoma With Autologous Heat Shock Protein gp96
Status: UNKNOWN
Conditions: Glioma of Brain
Interventions: BIOLOGICAL: gp96|DRUG: Temozolomide|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Two-Part, Single-Dose Study of the Pharmacokinetics of MK-8931 in Subjects With Renal Insufficiency (MK-8931-009 [P08535])
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: MK-8931
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Episodic Memory Before and After Surgery in Drug-resistant Partial Epilepsies
Status: UNKNOWN
Conditions: Epilepsy, Unspecified, Pharmacologically Resistant|Memory Impairment
Interventions: OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of an Automatic Segmentation Software (Pixyl.Neuro) to Track Lesions in Multiple Sclerosis Patients Via Cerebral MRI
Status: COMPLETED
Conditions: Multiple Sclerosis|Clinically Isolated Syndrome
Interventions: OTHER: Analysis of cerebral MRI with automatic segmentation software
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prone Positioning in Neurologically Deceased Potential Organ Donors to Improve Donor Lung Function and Lung Transplant Recipient Outcomes
Status: NOT_YET_RECRUITING
Conditions: Lung Transplant Failure
Interventions: OTHER: Protocolized protective mechanical ventilation in prone position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of a New Infant Formula on Growth and Cognition in Healthy Term Infants
Status: UNKNOWN
Conditions: Child Development
Interventions: DIETARY_SUPPLEMENT: Oral feeding of Investigational Formula (Stage 1&2)|DIETARY_SUPPLEMENT: Oral feeding of Control formula (Stage 1&2)|DIETARY_SUPPLEMENT: Breast feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Outcomes After Centrifugation Versus PureGraft for Fatgrafting to the Breast
Status: COMPLETED
Conditions: Fatgrafting to a Breast After Breast Conserving Therapy
Interventions: OTHER: Puregraft|OTHER: Centrifugation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Trigger Finger With Steroid Injection Versus Steroid Injection and Splinting
Status: UNKNOWN
Conditions: Trigger Finger|Stenosing Tenosynovitis
Interventions: PROCEDURE: Corticosteroid injection + Trigger Splint+ Education and Home exercises|PROCEDURE: Corticosteroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Sigh Ventilation to Increase Ventilator-Free Days in Victims of Trauma at Risk for Acute Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome
Interventions: OTHER: Sigh breaths
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Implementing Individualized Patient Reported Outcome Measures in Routine Care of Patients With Coronary Artery Disease
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease|Patient Acceptance of Health Care|Physician-Patient Relations
Interventions: OTHER: ePROM Survey
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Two Different Forms of Marine Oil on Indirect Markers of Muscle Damage and Soreness in Untrained Men
Status: COMPLETED
Conditions: Inflammation; Muscle
Interventions: DIETARY_SUPPLEMENT: ESPO-572®|DIETARY_SUPPLEMENT: PCSO-524®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: ACE1702 in Subjects With Advanced or Metastatic HER2-expressing Solid Tumors
Status: RECRUITING
Conditions: Locally Advanced Solid Tumor|Metastatic Cancer|Solid Tumor|HER2-positive Gastric Cancer|HER2-positive Metastatic Breast Cancer
Interventions: DRUG: ACE1702|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of RO4917523 in Pediatric Patients With Fragile X Syndrome
Status: COMPLETED
Conditions: Fragile X Syndrome
Interventions: DRUG: Placebo|DRUG: RO4917523|DRUG: RO4917523
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Pharmacology Study of MT-2990 in Seasonal Allergic Rhinitis Patients
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: MT-2990|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Differentiated Point-of-care Active Case Finding & Management Model to Eliminate Mother-to-Child Transmission of HIV in Malawi
Status: NOT_YET_RECRUITING
Conditions: HIV Prevention
Interventions: BEHAVIORAL: PAC-Man|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability of a Novel Malathion Formulation in Infants and Toddlers With Head Lice
Status: TERMINATED
Conditions: Lice Infestations
Interventions: DRUG: MALG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Adjuvant Trial of Chemotherapy vs Chemo-immunotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer|Adjuvant Chemotherapy
Interventions: DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Very Low Birth Weight Preterm Infant Bundled Care in the NICU
Status: COMPLETED
Conditions: Preterm Infants
Interventions: OTHER: 3-hour bundled care|OTHER: 6-hour bundled care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Wearables
Status: COMPLETED
Conditions: Dementia|Mild Cognitive Impairment|Alzheimer Disease
Interventions: DEVICE: In-Home Technology System|DEVICE: Limited In-Home Technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Effect of a Single Dose of CNTO 136 (Sirukumab) on CYP450 Enzyme Activities After Subcutaneous Administration in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Sirukumab|DRUG: Midazolam|DRUG: Warfarin|DRUG: Vitamin K|DRUG: Omeprazole|DRUG: Caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Investigating the Regulation of Reproductive Hormones in Adult Men
Status: COMPLETED
Conditions: Kallmann Syndrome|Hypogonadism|Gonadal Disorder
Interventions: DRUG: ketoconazole|DRUG: gonadotropin releasing hormone (GnRH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Retro-prospective Study of Safety & Performance of Round XTENDOBUTTON™ Fixation Device Post Knee Repair
Status: COMPLETED
Conditions: Knee Reconstruction
Interventions: DEVICE: Round XTENDOBUTTON Fixation Device used in suture fixation of ligaments and tendons in conjunction with an ULTRABUTTON™ product or ENDOBUTTON™ device.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioavailability Study of Dronabinol Capsules 10 mg Under Fasting Conditions
Status: COMPLETED
Conditions: To Determine Bioequivalence Under Fasting Conditions
Interventions: DRUG: Dronabinol|DRUG: Marinol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Safety and Efficacy of LX4211 With Metformin in Type 2 Diabetes Patients With Inadequate Glycemic Control on Metformin
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: 75 mg LX4211|DRUG: 200 mg LX4211|DRUG: 400 mg LX4211|DRUG: 200 mg LX4211|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnevist® Injection-enhanced MRA Compared to Non Contrast MRA for the Detection of Stenosis of the Renal Arteries
Status: COMPLETED
Conditions: Renal Artery Stenosis
Interventions: DRUG: Gadopentetate dimeglumine (Magnevist)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 1 Study of BPI-371153 in Subjects With Advanced Solid Tumors or Relapsed/Refractory Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumor|Lymphoma|NSCLC|HCC
Interventions: DRUG: BPI-371153
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of OV101 in Individuals With Angelman Syndrome (AS)
Status: COMPLETED
Conditions: Primary Disease or Condition Being Studied: Angelman Syndrome (AS)
Interventions: DRUG: Gaboxadol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Forced Fluid Removal in High Risk Acute Kidney Injury
Status: TERMINATED
Conditions: Acute Kidney Injury|Fluid Overload|Critical Illness
Interventions: DRUG: Furosemide (Furix)|OTHER: Continuous renal replacement therapy (CRRT)|OTHER: Resuscitation|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy of Elix's Cycle Balance and Its Impact on PMS and Menstrual Symptoms
Status: COMPLETED
Conditions: PMS|Menstrual Pain
Interventions: DIETARY_SUPPLEMENT: Elix Cycle Balance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Alzheimer's Disease: Therapeutic Potential of Estrogen
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Transdermal estradiol|DRUG: Medroxyprogesterone|DRUG: Placebo Patch|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cancer-related Fatigue in Patients With Breast Cancer Treatment With Zhengyuan Capsules
Status: NOT_YET_RECRUITING
Conditions: Cancer-related Fatigue
Interventions: DRUG: Zhengyuan Capsules|DRUG: Placebo contains 5%-10% Zhengyuan Capsule total mixed powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of a New Technique to Improve the Symptoms of Orofacial Discomfort in Patients With Peripheral Facial Paralysis
Status: COMPLETED
Conditions: Peripheral Nerve Facial Nerve Paralysis|Facial Nerve Diseases|Orofacial Pain
Interventions: PROCEDURE: occlusal adjustment.|BEHAVIORAL: Visual analog scale.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acceptability of Various Available Midazolam Formulations (Syrup, Rectal Suppository, Oro-dispersible Minitablet) in Clinical Practice
Status: RECRUITING
Conditions: Medication Palatability
Interventions: OTHER: Data collection on acceptability of midazolam administration by 2- to 10-year-old pediatric patients at UKBB
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p