pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pain Modulation - Experimental Assessments Using Different Modalities
Status: RECRUITING
Conditions: Low Back Pain|Compare Pain Modulation Assessments in Pain-free Cohorts
Interventions: OTHER: Cold Water Bath|OTHER: Neutral Water Bath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: 24-hour Efficacy and Tolerability of the Tafluprost-timolol Fixed Association Without Preservatives in Glaucomatous or Ocular Hypertensive Patients Already Treated With Latanoprost Preserved With BAK. A Prospective, Open Study of 3 Months Duration.
Status: UNKNOWN
Conditions: Glaucoma, Open-Angle|Ocular Hypertension
Interventions: DRUG: tafluprost/timolol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CD8+ T Cell Imaging During Pre-surgery Immunotherapy in People With Melanoma
Status: RECRUITING
Conditions: Melanoma|Melanoma Stage III
Interventions: DIAGNOSTIC_TEST: PET Scan|DRUG: Nivolumab|DRUG: Ipilimumab|PROCEDURE: Surgical Resection of Melanoma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT for the Effectiveness of 3 Orthodontic Retention Schemes on Post-treatment Stability and Gingival Recession
Status: UNKNOWN
Conditions: Relapse|Gingival Recession
Interventions: OTHER: 0.028 bonded to canines|OTHER: 0.027 7-strand bonded to all 6|OTHER: removable Hawley-type
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Attentional Bias Modification Through Eye-tracker Methodology (ABMET)
Status: COMPLETED
Conditions: Cognitive Deficits|Depression|Alteration of Cognitive Function
Interventions: BEHAVIORAL: Gaze training|BEHAVIORAL: Placebo intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Psilocybin Therapy for Depression in Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease|Depression
Interventions: DRUG: Psilocybin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PF-00299804 As A Single Agent, In Patients With Advanced Non-Small Cell Lung Cancer Who Have Failed Chemotherapy And Erlotinib
Status: COMPLETED
Conditions: Carcinoma, Non Small Cell Lung
Interventions: DRUG: PF-00299804|DRUG: PF-00299804
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesic Effects of Using Dexmedetomidine for Ultrasound Guided Thoracic Paravertebral Block
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: bupivacaine|DRUG: dexmedetomidin|DRUG: serum physiologic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Nilotinib on Safety, Biomarkers and Clinical Outcomes in Mild to Moderate Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer's Disease
Interventions: DRUG: Placebo Capsule(s) Once a Day by Mouth|DRUG: Nilotinib Capsule(s) Once a Day by Mouth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brentuximab Vedotin Plus DHAP in Relapsed or Refractory Hodgkin's Lymphoma
Status: RECRUITING
Conditions: Relapsed/Refractory Classical Hodgkin Lymphoma
Interventions: DRUG: Brentuximab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on the Prevention and Treatment of GIOP With Eldecalcitol
Status: NOT_YET_RECRUITING
Conditions: Rheumatoid Arthritis|Osteoporosis|Osteopenia
Interventions: DRUG: Eldecalcitol capsules|DRUG: Alfacalcidol tablets|DRUG: Calcium carbonate tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOLFIRINOX for 2nd-line Treatment of BTC
Status: COMPLETED
Conditions: Biliary Tract Cancer
Interventions: DRUG: 5-Fluorouracil|DRUG: Leucovorin|DRUG: Irinotecan|DRUG: Oxaliplatin|DRUG: 5% dextrose water
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of APL-1202 in Combination With Epirubicin Hydrochloride Versus Epirubicin Hydrochloride Alone in Intermediate and High-risk Chemo-refractory Non-muscle Invasive Bladder Cancer (NMIBC) Patients
Status: UNKNOWN
Conditions: Non-muscle Invasive Bladder Cancer
Interventions: DRUG: APL-1202 in combination with Epirubicin|DRUG: Placebo in combination with Epirubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TElmisartan and AMlodipine Single Pill sTudy With Patients Not on Goal With Mono rAas Therapy-switch
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: telmisartan/amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing of Cefazolin Plus Azithromycin Versus Cefazolin in Prevention of Febrile Morbidity After Emergency Cesarean Delivery
Status: COMPLETED
Conditions: Febrile Morbidity After Emergency Cesarean Section
Interventions: DRUG: Azithromycin Injection [Zithromax]|DRUG: Cefazolin|DRUG: Sodium Chloride 0.9% Intravenous Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Submucosal Dexamethasone After Periodontal Surgery
Status: COMPLETED
Conditions: Periodontal Pocket|Pain|Swelling/ Edema|Patient Satisfaction|Periodontitis
Interventions: DRUG: submucosal 8 mg (2 mL) dexamethasone application|DRUG: submucosal 2 mL 0.9% isotonic sodium chloride application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Inhaled Molgramostim Nebulizer Solution in Autoimmune Pulmonary Alveolar Proteinosis (aPAP)
Status: ACTIVE_NOT_RECRUITING
Conditions: Autoimmune Pulmonary Alveolar Proteinosis
Interventions: DRUG: Molgramostim|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: [C-11]PRB28
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: PPG Project 3 - PET/MRI of the Brain-hematopoiesis-atherosclerosis Axis in PTSD Patients
Status: COMPLETED
Conditions: PTSD|Trauma|Healthy
Interventions: DRUG: fluorodeoxyglucose (FDG)-PET/MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Study on the Selection of Time for Retreatment of Helicobacter Pylori After Eradication Failure
Status: COMPLETED
Conditions: Helicobacter Pylori
Interventions: DRUG: Amoxicillin , Levofloxacin and Esomeprazole|DRUG: Amoxicillin , Furazolidone and Esomeprazole|DRUG: Tetracycline , Furazolidone and Esomeprazole|DRUG: Amoxicillin,Levofloxacin and Vonoprazan fumarate|DRUG: Amoxicillin,Furazolidone and Vonoprazan fumarate|DRUG: Tetracycline,Furazolidone and Vonoprazan fumarate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Linking In With Advice and Supports for Men Impacted by Metastatic Cancer
Status: RECRUITING
Conditions: Survivorship|Prostate Cancer|Kidney Cancer|Urothelial Tract/Bladder Cancer, Nos|Testicular Cancer|Penile Cancer
Interventions: OTHER: Physiotherapy|OTHER: Dietitian Support|OTHER: Nursing and Psychosocial
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Cyclosporine or Corticosteroids as an Adjunct to Plasma Exchange in Thrombotic Thrombocytopenic Purpura (TTP)
Status: COMPLETED
Conditions: Thrombotic Thrombocytopenic Purpura
Interventions: DRUG: Cyclosporine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Qlaris Phase 2 Study in NTG Patients
Status: NOT_YET_RECRUITING
Conditions: Normal Tension Glaucoma (NTG)|Low-Tension Glaucoma, Bilateral|Low-Tension Glaucoma, Unspecified Eye|Glaucoma
Interventions: DRUG: QLS-111 ophthalmic solution, (0.015%)|DRUG: QLS-111 ophthalmic solution, (0.03%)|OTHER: QLS-111 ophthalmic vehicle solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of Telmisartan and Dipyridamole After Co-administration Compared to the Bioavailability of Telmisartan or Dipyridamole Alone in Healthy Female and Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: telmisartan|DRUG: ASA/ER-DP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Aprepitant in Prurigo Patients
Status: COMPLETED
Conditions: Pruritus
Interventions: DRUG: Aprepitant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Z-SEA-SIDE: Sirolimus Versus Everolimus Versus Zotarolimus-eluting Stent Assessment in Bifurcated Lesions and Clinical SIgnificance of Residual siDE-branch Stenosis
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Stenosis
Interventions: DEVICE: Sirolimus eluting stent|DEVICE: Everolimus eluting stent|DEVICE: Zotarolimus eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Who Have Received Chemotherapy
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: imatinib mesylate|GENETIC: gene expression analysis|GENETIC: mutation analysis|GENETIC: polymerase chain reaction|OTHER: flow cytometry|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Narrative Intervention for Long COVID-19 (NICO)
Status: ACTIVE_NOT_RECRUITING
Conditions: Long COVID|Long Covid19
Interventions: BEHAVIORAL: Narrative Intervention for Long COVID-19 (NICO)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: International,Multi-Center,Open Label,Randomized Study Assessing the Safety and Efficacy of a Monthly Dosing Regimen of Ozarelix Versus Goserelin Depot in Men With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Ozarelix|DRUG: Goserelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quality of Life Outcomes of HUMIRA in Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Ankylosing Spondylitis (AS) After Unsustainable Response to Biologicals and Disease Modifying Antirheumatic Drugs
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Ankylosing Spondylitis|Psoriatic Arthritis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Detection of PitNET Tissue During TSS Using Bevacizumab-800CW
Status: COMPLETED
Conditions: Pituitary Tumor|Pituitary Adenoma|Pituitary Macroadenoma
Interventions: DRUG: Bevacizumab-IRDye800CW|DEVICE: Molecular Fluorescence Endoscopy platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Brightline-4: A Study to Test How Well Brigimadlin is Tolerated by People With a Type of Cancer Called Dedifferentiated Liposarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Liposarcoma, Dedifferentiated
Interventions: DRUG: Brigimadlin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of 2% Chlorhexidine Gluconate Impregnated Cloth Bathing in Preoperative Skin Preparation
Status: COMPLETED
Conditions: Surgical Site Infection
Interventions: OTHER: towels impregnated with 2% chlorhexidine gluconate|OTHER: chlorhexidine gluconate 2% liquid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Antihypercholestrolemic Effect of a Combined Nutritional Supplementation of Standardized Extracts of Amla, Walnut, Red Yeast Rice and Olive
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DIETARY_SUPPLEMENT: Cholesfytol NG®) supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Using Patient Specific Zirconium Dioxide Implant Versus Patient Specific Titanium Implant in Treatment of Chronic Condylar Dislocation
Status: COMPLETED
Conditions: Recurrent Dislocation of Temporomandibular Joint (Disorder)
Interventions: DEVICE: eminoplasty with patient specific Zirconium dioxide onlay implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Healthy Mediation Adherence To Transform and Effectively Relieve Symptoms
Status: COMPLETED
Conditions: COPD|Diabetes|Hypertension
Interventions: BEHAVIORAL: Supportive counseling|BEHAVIORAL: Education on SMB|BEHAVIORAL: Psychoeducation on ATs for maladaptive beliefs (if applicable)|BEHAVIORAL: Psychoeducation on emotional response (if applicable)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intranasal Corticosteroids on Pulmonary Symptoms in Asthmatics With Nasal Congestion
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: corticosteroid nasal spray|DRUG: placebo nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment With [90]Y-Ibritumomab Tiuxetan Versus no Treatment in Patients With Follicular Non Hodgkin Lymphoma (Stage III or IV) Having Achieved a Partial or Complete Remission After First Line Chemotherapy
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin
Interventions: BIOLOGICAL: Zevalin ([90]Y-ibritumomab tiuxetan, BAY86-5128)|OTHER: no treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of Effective Vitamin D Replacement and Monitoring Strategies in Vitamin D Deficiency State
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DRUG: Vitamin D3 600,000 units IM|DRUG: Vitamin D3 600,000 Orally|DRUG: Vitamin D3 200,000 units IM|DRUG: Vitamin D3 200,000 Orally
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect on Cerebral Oxygenation of Retrograde Autologous Priming of the Cardiopulmonary Bypass Circuit in Cardiac Surgery Patients
Status: UNKNOWN
Conditions: Postoperative Cognitive Dysfunction
Interventions: PROCEDURE: retrograde autologous priming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Persistent Atrial Fibrillation With Sphere-9 Catheter and Affera Mapping and Ablation System
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Mapping and Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Functional Importance of a Powered Multifunction Wrist Protocol
Status: ACTIVE_NOT_RECRUITING
Conditions: Upper Limb Amputation at the Hand|Upper Limb Amputation at the Wrist|Amputation|Amputation; Traumatic, Limb
Interventions: DEVICE: Commercially available device|DEVICE: Non FDA registered device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase I Study Evaluating Safety and Efficacy of C-CAR011 Treatment in Adult Subjects With r/r CD19+B-ALL
Status: UNKNOWN
Conditions: Relapsed or Refractory Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: C-CAR-011
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Value of an Intrathecal Synthesis Index of Specific Antitreponema IgG for Neurosyphilis Diagnosis
Status: COMPLETED
Conditions: Neurosyphilis
Interventions: DIAGNOSTIC_TEST: Measure of an antibody index for intrathecal synthesis of specific anti-Treponema pallidum IgG by ELISA.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial Investigating the Effect of Acute Hypoglycaemia on Cognitive Function and Brain Activation Patterns in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: OTHER: glucose clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Kinesio Tape Versus Diaphragmatic Breathing Exercise In Post COVID-19
Status: COMPLETED
Conditions: Post COVID-19 Condition
Interventions: OTHER: Pursed lip breathing|OTHER: Cognitive Behavior Therapy|OTHER: Diaphragmatic breathing exercise|OTHER: Kinesio tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Combined Ultrasound Guided Steroid Injection and Splinting in Patients With Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: DRUG: Triamcinolone Acetonide|DEVICE: thermoplastic wrist splint|DRUG: lidocaine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase 3, Randomized, Placebo-Controlled Study of Tinlarebant to Explore Safety and Efficacy in Geographic Atrophy
Status: RECRUITING
Conditions: Geographic Atrophy
Interventions: DRUG: Tinlarebant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Nighttime Dosing of Sublingual Tizanidine (12 mg) in Multiple Sclerosis (MS) Patients With Significant Spasticity
Status: COMPLETED
Conditions: Muscle Spasticity
Interventions: DRUG: Tizanidine (sublingual or oral)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Vitamin D Supplementation on Cardiovascular Risk Factors
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DRUG: Cholecalciferol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicentre, Randomised, Open-label, Controlled Study to Evaluate the Effects of Saizen® on Cardiac Function in Growth Hormone Deficient(GHD) Subjects During the Transition Phase From Childhood to Adulthood
Status: COMPLETED
Conditions: Dwarfism|Growth Hormone Deficiency
Interventions: DRUG: r-hGH|DRUG: r-hGH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Feasibility Study Combining Brentuximab Vedotin With Second Line Salvage Chemotherapy (DHAP) in Hodgkin Lymphoma Patients
Status: UNKNOWN
Conditions: Hodgkin Lymphoma|Refractory|Relapse
Interventions: DRUG: DHAP|DRUG: Brentuximab Vedotin|OTHER: Autologous Peripheral Blood Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Comparison Study of SYHX2011 and Abraxane® in Patients With Advanced Breast Cancer
Status: UNKNOWN
Conditions: Advanced Breast Cancer
Interventions: DRUG: SYHX2011 and Abraxane®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of Pulsed Radiofrequency of the Median Nerve Under Ultrasound Guidance in Patients With Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: DEVICE: Pulsed Radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of LivPhcD Capsules in the NAFLD Subjects
Status: RECRUITING
Conditions: NAFLD
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: 2 cap.LivPhcD/per day|DIETARY_SUPPLEMENT: 4 cap.LivPhcD/per day|DIETARY_SUPPLEMENT: 6 cap.LivPhcD/per day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Weight Management in Obese Pregnant Underserved African American Women
Status: COMPLETED
Conditions: Obesity|Pregnancy|Weight Gain
Interventions: BEHAVIORAL: Standard Parents As Teachers (PAT)|BEHAVIORAL: Parents As Teachers Plus (PAT+)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Unilateral and Bilateral Transforaminal Epidural Steroid Injection
Status: COMPLETED
Conditions: Pain, Chronic
Interventions: PROCEDURE: unilateral transforaminal epidural steroid block|PROCEDURE: bilateral transforaminal epidural steroid block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Can SARS-CoV-2 Viral Load and COVID-19 Disease Severity be Reduced by Resveratrol-assisted Zinc Therapy
Status: TERMINATED
Conditions: Covid19|SARS-CoV Infection
Interventions: DIETARY_SUPPLEMENT: Zinc Picolinate|DIETARY_SUPPLEMENT: Resveratrol|DIETARY_SUPPLEMENT: Zinc Picolinate Placebo|DIETARY_SUPPLEMENT: Resveratrol Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluating Myocardial Injury for Defibrillation Threshold Testing Methods for ICD Implantation
Status: COMPLETED
Conditions: Cardiomyopathy|Heart Failure|Cardiac Arrhythmia
Interventions: DEVICE: Standard Defibrillation Testing|DEVICE: Upper Limit of Vulnerability Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Testing the Cognitive Facilitation Effect by Dietary Supplementation of MelaGene+ Drink
Status: COMPLETED
Conditions: Cognitive Change
Interventions: DIETARY_SUPPLEMENT: placebo|DIETARY_SUPPLEMENT: MelaGene+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: An Open-Label Phase 1/2 Study of Itacitinib in Combination With Osimertinib in Subjects With Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer
Interventions: DRUG: Itacitinib|DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Diagnostic Value of Combinatory EUS and ERCP in Unclear Lesions
Status: COMPLETED
Conditions: Neoplasms|Biliary Stricture|Biliary Tract Neoplasms|Biliary Tract Diseases
Interventions: PROCEDURE: Combinatory EUS and ERCP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: BIS of Sedation Depth During Flexible Bronchoscopy.
Status: UNKNOWN
Conditions: Pulmonary Disease
Interventions: DRUG: Fentanyl|DRUG: Midazolam|DRUG: Propofol|DEVICE: Bispectral Index monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regorafenib and Durvalumab for the Treatment of High-Risk Liver Cancer
Status: RECRUITING
Conditions: Stage IB Hepatocellular Carcinoma AJCC v8|Stage II Hepatocellular Carcinoma AJCC v8|Stage III Hepatocellular Carcinoma AJCC v8|Stage IIIA Hepatocellular Carcinoma AJCC v8
Interventions: BIOLOGICAL: Durvalumab|DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Communication and Activation in Pain to Enhance Relationships and Treat Pain With Equity
Status: COMPLETED
Conditions: Pain
Interventions: BEHAVIORAL: Communication and Activation in Pain to Enhance Relationships and Treat Pain with Equity (COOPERATE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy Study of Stain Control of a 67% Sodium Bicarbonate Containing Toothpaste on Chlorhexidine Tooth Staining
Status: COMPLETED
Conditions: Oral Hygiene
Interventions: OTHER: Sodium bicarbonate/ Sodium Fluoride|OTHER: Sodium fluoride|DRUG: Chlorhexidine digluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: 'Effect of CRT on Defibrillation Threshold Estimates' Study
Status: COMPLETED
Conditions: Sudden Cardiac Death
Interventions: DEVICE: Cardiac Resynchronization Therapy - Defibrillator (CRT-D)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Indiana University Gastrointestinal Motility Diagnosis Registry
Status: RECRUITING
Conditions: Eosinophilic Esophagitis|Gastroesophageal Reflux Disease (GERD)|Gastroparesis|Functional Vomiting|Irritable Bowel Syndrome (IBS)|Constipation|Chronic Intestinal Pseudo-obstruction|Fecal Incontinence|Small Intestinal Bacterial Overgrowth
Interventions: OTHER: no intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of a Single Oral Dose of Sweet Protein Sweelin® on Blood Glucose and Insulin Levels in Healthy Adults
Status: NOT_YET_RECRUITING
Conditions: Healthy Adults
Interventions: OTHER: Sweet Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Can Latency of Action in Infraclavicular Brachial Plexus Block be Shortened With Warmed Bupivacaine?
Status: COMPLETED
Conditions: Effect Increased
Interventions: DRUG: Bupivacaine Hydrochloride 5 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Fish Oil Based Lipid Emulsion to Enhance Recovery in High-Risk Cardiac Surgery Patients.
Status: RECRUITING
Conditions: Cardiac Surgery|High Risk Patients|Intensive Care Unit|Cardiopulmonary Bypass|Valve Surgeries
Interventions: DRUG: Long-chain n-3 fatty acids|DRUG: Intravenous 0.9% Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Bicalutamide in Combination With Sunitinib in Patients With TKIs-resistant RCC
Status: NOT_YET_RECRUITING
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Bicalutamide in combination with Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate How Daily Dosing With Enzalutamide Affects the Metabolism of Caffeine and Dextromethorphan in Men With Prostate Cancer
Status: COMPLETED
Conditions: Pharmacokinetics of Dextromethorphan|Pharmacokinetics of Caffeine|Prostate Cancer
Interventions: DRUG: Caffeine|DRUG: Dextromethorphan|DRUG: Enzalutamide|DRUG: Enzalutamide Placebo to Match (PTM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Abbreviated MRI Using Gadoxetic Acid Versus CT for Surveillance of Recurrent HCC After Curative Treatment
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DIAGNOSTIC_TEST: AMRI|DIAGNOSTIC_TEST: CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Safety and Proof-of-Concept (POC) Study With AMT-130 in Adults With Early Manifest Huntington's Disease
Status: RECRUITING
Conditions: Huntington's Disease
Interventions: GENETIC: intra-striatal rAAV5-miHTT|OTHER: Imitation (sham) surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CsA+ATG+AVA vs. CsA+AVA for the Treatment of Newly-diagnosed SAA in the Elderly
Status: NOT_YET_RECRUITING
Conditions: Aplastic Anemia
Interventions: DRUG: Ciclosporin|DRUG: Avatrombopag|DRUG: Anti-Human Thymocyte Immunoglobulin, Rabbit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deep Serratus Anterior Plane Block vs Surgically-placed Paravertebral Block for VATS Surgery
Status: COMPLETED
Conditions: Thoracic Diseases|Thoracic Surgery|Rib Fractures|Pain, Postoperative|Pain, Procedural|Anaesthesia, Regional
Interventions: PROCEDURE: Deep serratus anterior plane block|PROCEDURE: Surgically-placed paravertebral block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Practice Guidelines for Neck and Low Back Pain in Outpatient Physical Therapy
Status: COMPLETED
Conditions: Neck Pain|Low Back Pain
Interventions: BEHAVIORAL: Clinical Practice Guideline Implementation|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Correlation Between Intra-abdominal Pressure, Biomarkers of Bacterial Translocation and Intestinal Wall Damage
Status: ACTIVE_NOT_RECRUITING
Conditions: Intraabdominal Hypertension|Multi-Organ Disorder|Translocation Syndrome
Interventions: DIAGNOSTIC_TEST: immunoenzyme analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Short-course Methenamine Hippurate for Prevention of Post-operative UTI
Status: COMPLETED
Conditions: Urinary Tract Infections|Catheter-Related Infections
Interventions: DRUG: methenamine hippurate|DRUG: Ciprofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Multicenter Evaluation of Right Colon Polyp Miss Rates Using Water Exchange Versus CO2 Insufflation
Status: COMPLETED
Conditions: Right Colon Adenoma Miss Rate|Right Colon Hyperplastic Polyp Miss Rate
Interventions: PROCEDURE: Colon Polypectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Dose Dense MVAC in MIBC and Locally Advanced Urothelial Carcinoma
Status: UNKNOWN
Conditions: Muscle Invasive Bladder Cancer|Urothelial Carcinoma|Neoadjuvant Chemotherapy
Interventions: DRUG: dose dense MVAC with pegylated GCSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Triage Nurse Initiated Radiographs According to OAR
Status: UNKNOWN
Conditions: Ankle Fracture
Interventions: OTHER: Triage nurses applying the OAR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cyclic Exclusive Enteral Nutrition as Maintenance Therapy for Pediatric Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DIETARY_SUPPLEMENT: MODULEN IBD|DIETARY_SUPPLEMENT: MODULEN IBD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of High Intensity Laser on Mechanical and Physiological Findings in Pregnant Women With Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome|Pregnancy Related
Interventions: DEVICE: High intensity laser therapy|OTHER: Conventional Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Protective Role of GABA Stimulation Before Ileostomy Closure
Status: NOT_YET_RECRUITING
Conditions: Ileostomy; Complications
Interventions: DIETARY_SUPPLEMENT: preoperative stimulation of the efferent loop with GABA before ileostomy closure surgery|DIETARY_SUPPLEMENT: preoperative stimulation of the efferent loop with only physiological saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Prevalence of Hypovolemia and Heart Failure in Non-cardiac Surgery
Status: COMPLETED
Conditions: Hypovolemia|Heart Failure|Diastolic Dysfunction|Systolic Dysfunction|Venous; Return (Anomaly)
Interventions: DIAGNOSTIC_TEST: Echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Postoperative Bleeding Prevention in Massive Bone Tumour Resection
Status: TERMINATED
Conditions: Blood Loss|Bone Tumour
Interventions: DRUG: Tranexamic Acid|DRUG: Fibrin glue|PROCEDURE: Electrocauterization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrophysiological Investigation and rTMS Intervention of Ambulatory Central Processing of Freezing of Gait in Parkinson's Disease
Status: WITHDRAWN
Conditions: Parkinson's Disease|Parkinson's Disease With Freezing of Gait
Interventions: DEVICE: real iTBS|DEVICE: sham iTBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sinusitis and Facial Pain Disorders Anti-Depression Trial
Status: TERMINATED
Conditions: Chronic Sinusitis|Facial Pain Disorder|Depression
Interventions: DRUG: escitalopram|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Label Study to Examine the Effects of DAS181 Administered by Dry Powder Inhaler (DPI) or Nebulized Formulation in Immunocompromised Subjects With Parainfluenza (PIV) Infection
Status: COMPLETED
Conditions: Parainfluenza
Interventions: DRUG: DAS181-F02 Dry Powder in Bulk|DRUG: DAS181-F02 Nebulized Formulation Inhaled Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Leg and Heel Massage on Pain During Heel Blood Collection Newborns
Status: RECRUITING
Conditions: Pain|Infant ALL
Interventions: OTHER: Baby Foot and Leg Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pharmacokinetics of Different Mode Administration of Intranasal Dexmedetomidine
Status: COMPLETED
Conditions: Bioavailability|Dexmedetomidine
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CAR T Cells in Treating Patients With Malignant Gliomas Overexpressing EGFR
Status: UNKNOWN
Conditions: Advanced Glioma
Interventions: BIOLOGICAL: anti-EGFR CAR T
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of the Dexcom G6 Continuous Glucose Monitoring System in Non-Critically Ill Patients in the Inpatient Setting
Status: UNKNOWN
Conditions: Patients Needing Glucose Control
Interventions: DEVICE: Continuous Glucose Monitoring System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Vaccine Therapy With or Without Sargramostim in Treating Patients With Stage IIB, Stage IIC, Stage III, or Stage IV Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: incomplete Freund's adjuvant|BIOLOGICAL: multi-epitope melanoma peptide vaccine|BIOLOGICAL: sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of a Long-Acting r-Factor 7a (Factor VIIa) in Adult Men With Hemophilia A or B
Status: COMPLETED
Conditions: Hemophilia A|Hemophilia B
Interventions: DRUG: MOD-5014
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NSAIDs vs. Coxibs in the Presence of Aspirin
Status: RECRUITING
Conditions: Rheumatoid Arthritis|Cardiovascular Diseases
Interventions: DRUG: celecoxib 200mg capsule|DRUG: naproxen sodium 550mg tablet|DRUG: Aspirin 81mg tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Krill Oil on Endothelial Function in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type II Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Krill Oil (Supplement A)|DIETARY_SUPPLEMENT: Placebo (Supplement B)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase III Study of Toripalimab（JS001） Combined With Lenvatinib for Advanced HCC
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Hepatocellular Carcinoma (HCC)
Interventions: COMBINATION_PRODUCT: Toripalimab combined with Lenvatinib|COMBINATION_PRODUCT: Placebo combined with Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating CCI-779 and Letrozole in Post-menopausal Women With Breast Cancer
Status: TERMINATED
Conditions: Breast Neoplasms|Neoplasm Metastasis
Interventions: DRUG: Temsirolimus (CCI-779) for 34 months|DRUG: Letrozole for 34 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Drug-Drug Interaction Study Between PF-06882961 and PF-06865571 in Healthy Adult Participants and Overweight Adults or Adults With Obesity Who Are Otherwise Healthy
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: PF-06882961 followed by PF-06882961/PF-06865571|DRUG: PF-06882961/PF-06865571 followed by PF-06882961|DRUG: PF-06882961 + PF-06865571
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Medical-economic Evaluation of the Care of Refractory Ascites by Implantation of Alfapump® Device in Cirrhotic Patients
Status: RECRUITING
Conditions: Ascites|Paracentesis|Cirrhosis
Interventions: DEVICE: Alphapump|PROCEDURE: Ascites puncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral Supplementation With Curcumin (Turmeric) in Patients With Proteinuric Chronic Kidney Disease
Status: COMPLETED
Conditions: Proteinuria
Interventions: DRUG: Curcumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Daily Ambulatory Remote Monitoring System For Post-Dischage Management Of ADHF
Status: UNKNOWN
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: PROCEDURE: Home-based remote heart failure management|PROCEDURE: Home-based physiological parameter recording only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of HAT1 in Patients With Moderate to Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: HAT1 topical cream|DRUG: Vehicle cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Indacaterol Once Daily Versus Salmeterol Twice Daily in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Indacaterol 150 µg|DRUG: Salmeterol 50 µg|DRUG: Placebo to indacaterol|DRUG: Placebo to salmeterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 2-part Study Consisting of Multiple Ascending Dose (MAD) Safety Study, and a Dose-finding Masked Study to Assess the Safety and Efficacy of Intravitreal (IVT) EYE103 in Patients With Diabetic Macular Edema (DME) or Neovascular Age-related Macular Degeneration (NVAMD)
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration (NVAMD)|Diabetic Macular Edema (DME)
Interventions: DRUG: EYE103
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-Coated Balloon vs. Drug-Eluting Stent for Clinical Outcomes in Patients With Large Coronary Artery Disease
Status: RECRUITING
Conditions: Coronary Artery Disease|Myocardial Ischemia|Acute Coronary Syndrome|Coronary Stenosis|De Novo Stenosis
Interventions: DEVICE: SeQuent® Please NEO drug-coated balloon catheter|DEVICE: Current-generation drug-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Additional Analysis of Data From the PARADIGM Exploratory Study (NCT02394834) in Patients With Advanced/Recurrent Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: mFOLFOX6 + panitumumab combination therapy|DRUG: mFOLFOX6 + bevacizumab combination therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Measurement of Glucose Metabolism in Humans: Effect of Recurrent Hypoglycemia on Hypothalamic GABA
Status: COMPLETED
Conditions: Type 1 Diabetes|Healthy
Interventions: OTHER: hypoglycemia (low blood sugar) and MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation
Status: COMPLETED
Conditions: Vasomotor Rhinitis
Interventions: OTHER: Cold-dry air provocation|OTHER: Warm-moist air provocation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Lamotrigine add-on Therapy for Bipolar Disorder and Cocaine Dependency
Status: COMPLETED
Conditions: Bipolar Disorder|Cocaine Dependence
Interventions: DRUG: Lamotrigine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Dexamethasone Implant to Intravitreal Aflibercept in Subjects With Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Dexamethasone implant|DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigator-Sponsored Protocol - Continued Use of Ibalizumab
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: ibalizumab 800mg Q2Weeks|DRUG: ibalizumab 2000mg Q4Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant to General Anesthesia in Patients Undergoing Major Abdominal Surgeries
Status: UNKNOWN
Conditions: Stress Related Disorder
Interventions: DRUG: Dexmedetomidine|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION