pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: An Eight-Week Study to Evaluate the Efficacy and Safety of SR58611A in Elderly Patients With Generalized Anxiety Disorder
Status: TERMINATED
Conditions: Anxiety Disorders
Interventions: DRUG: SR58611A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: INtestinal Failure, multiPle Organ Failure ANd CItrulline Assessment
Status: COMPLETED
Conditions: Citrulline|Organ Failure, Multiple|Gastro Intestinal Failure|Intra Abdominal Pressure
Interventions: BIOLOGICAL: Monitoring of plasmatic levels of Citrulline|DEVICE: Intra-abdominal pressure monitoring|BIOLOGICAL: Monitoring of plasmatic levels of Arginine and Glutamine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nutritional Study of Fish Oil in Skin Quality in Healthy Women
Status: UNKNOWN
Conditions: Skin Health
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Ceto 10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Tolerability of N-Acetylcysteine When Administered With Pirfenidone to Participants With Idiopathic Pulmonary Fibrosis (IPF)
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Matching Placebo|DRUG: N-acetylcysteine|DRUG: Pirfenidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Depression and Social Isolation in Older Adults With Dementia With Home-based Telehealth Delivered Behavioral Activation + Caregiver Facilitation.
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Behavioral Activation for Depression
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Conducted in Subjects With Relapsed/Refractory Multiple Myeloma (MM); to Determine Dose of Afuresertib in Combination With Carfilzomib (Part 1) and to Investigate the Safety, Pharmacokinetic and Clinical Activity of the Combination Compared With Carfilzomib Alone (Part 2)
Status: TERMINATED
Conditions: Cancer
Interventions: DRUG: Afuresertib|DRUG: Carfilzomib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Chest Pain in Chemo-treated Cancer Patients
Status: COMPLETED
Conditions: Solid Carcinoma|5-Fluorouracil Toxicity|Cardiotoxicity|Chemotherapeutic Toxicity|Acute Coronary Syndrome|Coronary Artery Calcification|Chest Pain
Interventions: PROCEDURE: Cardiologic assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CCI-779 in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia
Status: TERMINATED
Conditions: Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Hodgkin Lymphoma|Refractory Chronic Lymphocytic Leukemia
Interventions: DRUG: temsirolimus|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0212 Celecoxib in Treating Patients With High-Grade Squamous Intraepithelial Lesions of the Cervix
Status: WITHDRAWN
Conditions: Stage 0 Cervical Cancer|High-grade Squamous Intraepithelial Lesion
Interventions: DRUG: celecoxib|PROCEDURE: anti-cytokine therapy|PROCEDURE: antiangiogenesis therapy|PROCEDURE: biological therapy|PROCEDURE: cancer prevention intervention|PROCEDURE: chemoprevention of cancer|PROCEDURE: enzyme inhibitor therapy|PROCEDURE: growth factor antagonist therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effect of Viral Load on Intrahepatic Recurrence in Hepatitis B Virus (HBV)-Related Hepatocellular Carcinoma (HCC)
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular|Chronic Hepatitis B
Interventions: PROCEDURE: PEIT|PROCEDURE: RFTA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Bone Marrow Transplant for Inherited Metabolic Disorders
Status: COMPLETED
Conditions: Mucopolysaccharidosis|Hurler Syndrome|Hunter Syndrome|Maroteaux-Lamy Syndrome|Sly Syndrome|Alpha Mannosidosis|Fucosidosis|Aspartylglucosaminuria|Adrenoleukodystrophy (ALD)|Krabbe Disease|Metachromatic Leukodystrophy (MLD)|Sphingolipidoses|Peroxisomal Disorders
Interventions: DRUG: Campath-1H|DRUG: Cyclophosphamide|DRUG: Busulfan|PROCEDURE: Allogeneic stem cell transplantation|DRUG: Cyclosporine A|DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intralesional Sclerosant for in Transit and Cutaneous Melanoma Metastases
Status: WITHDRAWN
Conditions: Melanoma|In-Transit Metastasis of Cutaneous Melanoma
Interventions: DRUG: Polidocanol Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Imatinib Versus Interferon-α Plus Cytarabine in Patients With Newly Diagnosed Philadelphia Chromosome Positive Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia
Interventions: DRUG: imatinib mesilate|DRUG: interferon-alpha (INF-a)|DRUG: cytarabine (ARA-C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Scalp Block With Bupivacaine Versus Levobupivacaine
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Levobupivacaine|DRUG: Bupivacaine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Combined Treatment of Methotrexate + Glucocorticoids Versus Glucocorticoids Alone in Patients With PM and DM
Status: COMPLETED
Conditions: Polymyositis|Dermatomyositis
Interventions: DRUG: Prednisone|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Graded Motor Imagery for Women at Risk for Developing Type I CRPS Following Closed Treatment of Distal Radius Fractures
Status: COMPLETED
Conditions: Musculoskeletal Pain|Fractures, Closed|Distal Radius Fracture|Complex Regional Pain Syndromes
Interventions: BEHAVIORAL: Standard Care|BEHAVIORAL: Motor Representation Techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Safety, Tolerability and Pharmacokinetics of STI-1558 in Healthy Volunteers
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: STI-1558|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Multiple Oral Administrations of TNP-2092 Capsules in Asymptomatic Healthy People With Helicobacter Pylori Infection
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: TNP-2092 capsules|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ASP8302 Single and Multiple Ascending Oral Dose Study in Non-elderly Healthy Japanese Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: ASP8302|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mulligan Rotational Movement Versus Medial Gapping Technique in Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: MULLIGAN ROTATIONAL MOVEMENT|OTHER: Medial gapping technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of GK Activator (2) in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: GK Activator (2)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Immunogenicity and Reactogenicity of Recombinant Hepatitis B Vaccine (Adjuvanted & New Formulation) and Engerix™-B
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Engerix™-B|BIOLOGICAL: HBV-MPL 208129|BIOLOGICAL: Vaccine containing HBsAg absorbed on aluminium salts - experimental formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Uridine Adolescent Bipolar Depression Randomized Controlled Trial
Status: COMPLETED
Conditions: Bipolar Disorder|Bipolar Depression|Manic Depression
Interventions: DRUG: Uridine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Genetic Testing for Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: GENETIC: genetic testing for type 2 diabetes|BEHAVIORAL: Conventional risk counseling|BEHAVIORAL: eye disease counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Mircera (C.E.R.A.) in Patients With Pre-Dialysis Chronic Renal Anemia
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: methoxy polyethylene glycol-epoetin beta [Mircera]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insular Inhibitory Neuromodulation to Reduce Cigarette Craving and Alter Brain Function in Smokers
Status: COMPLETED
Conditions: Smoking
Interventions: DEVICE: Repetitive transcranial magnetic stimulation, MagStim Rapid2|DEVICE: Sham repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pilot Study of Financial Navigation Program for Improving Financial Toxicity Among Breast Cancer in China
Status: RECRUITING
Conditions: Breast Neoplasm Female|Financial Toxicity|Financial Navigation
Interventions: BEHAVIORAL: Financial Navigation|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study on the Safety of Drug BAY2586116 and How it Works in Patients With Obstructive Sleep Apnea (a Sleep Disorder Caused by the Narrowing and Collapse of the Airway During Sleep) Including the Blood Level of the Drug and Effect of Its Doses and Routes of Administration
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DRUG: BAY2586116 (A1)|DRUG: Placebo (A2)|DRUG: BAY2586116 (B1)|DRUG: BAY2586116 (B2)|DRUG: BAY2586116 (B3)|DRUG: BAY2586116 (C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study Evaluating the Effects of Memantine on Brain Atrophy in Patients With Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Memantine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Testosterone Administration on Drug-Induced QT Interval Prolongation and Torsades de Pointes
Status: COMPLETED
Conditions: Long QT Syndrome
Interventions: DRUG: Testosterone|DRUG: Progesterone|DRUG: Placebo|DRUG: Ibutilide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Use of Electrical Stimulation by Capacitive Field in the Repair of Skin Burns and Quality of Life
Status: UNKNOWN
Conditions: Burns|Wound Healing
Interventions: OTHER: Electrical Stimulation by Capacitive Field|OTHER: Electrical Stimulation by Capacitive Field Placebo Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NO3-rich Beet Juice and Exercise on Postmenopausal Women Cardiovascular Health
Status: RECRUITING
Conditions: Arterial Hypertension|Postmenopausal; Menorrhagia|Cardiovascular Diseases
Interventions: DIETARY_SUPPLEMENT: Beetroot juice rich in nitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Comparison of Flexible Endoscopic Polidocanol Liquid and Foam Sclerotherapy in Cirrhotic Patients With Bleeding From Internal Hemorrhoids
Status: NOT_YET_RECRUITING
Conditions: Liver Cirrhosis|Internal Hemorrhoid
Interventions: PROCEDURE: Sclerotherapy with 1.5% polidocanol|PROCEDURE: Foam sclerotherapy.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Near Infrared Fluorescence Cholangiography (NIRF-C) During Cholecystectomy
Status: COMPLETED
Conditions: Cholecystitis
Interventions: DRUG: Injection of indocyanine green (ICG)|DEVICE: Near Infrared Cholangiography Fluorescence (NIRF-C)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of Vaginal Tampon Training Added to Pelvic Floor Muscle Training in Stress Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: BEHAVIORAL: Pelvic Floor Muscle Training|BEHAVIORAL: Vaginal Tampon Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Safety and Efficacy of Two Rosacea Products in the Treatment of Facial Erythema of Rosacea
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: Brimonidine Topical Gel, 0.33 percent (Perrigo)|DRUG: Brimonidine Topical Gel, 0.33 percent (Reference)|DRUG: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Supplement Study: Strength, Testosterone, Sexual Function, Quality of Life
Status: COMPLETED
Conditions: Muscular Weakness|Sexual Behavior|Quality of Life
Interventions: DIETARY_SUPPLEMENT: Formula 1|DIETARY_SUPPLEMENT: Formula 2|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Exercise-based Cardiac Rehabilitation in Patients With Aortic Stenosis After Transcatheter Aortic Valve Implantation
Status: RECRUITING
Conditions: Aortic Valve Stenosis
Interventions: OTHER: Physiotherapist-led exercise based cardiac rehabilitation (PT-X)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treating Pain to Reduce Disability Among Older Home Health Patients
Status: COMPLETED
Conditions: Arthritis - Post Surgical|Other Activity-limiting Pain
Interventions: BEHAVIORAL: Cognitive-Behavioral Pain Self-management Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Crossover Comparative Bioavailability Study of Eslicarbazepine Acetate Versus To-be-marketed Formulation
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: BIA 2-093
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Addıtıonal Surgery On Muscle Strength, Proprıoceptıon And Balance In Anterıor Crucıate Lıgament Surgery
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injuries|Meniscus Lesion
Interventions: OTHER: Muscle strength measurement|OTHER: Knee joint proprioception|OTHER: Balance|OTHER: Fall risk test|OTHER: Tegner Activity Level|OTHER: Lysholm Knee Scoring Scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The PATHFINDER Study: A Feasibility Trial
Status: COMPLETED
Conditions: Coronary Artery Disease|Delirium
Interventions: DRUG: Ropivacaine|DRUG: Ketamine|DRUG: Remifentanil|DRUG: Dexmedetomidine|DRUG: Rocuronium|DRUG: Propofol|DRUG: Sevoflurane|DRUG: Dexmedetomidine|DRUG: Propofol|DEVICE: EEG monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Can Modified Coronally Advanced Tunnel be an Alternative in Gingival Phenotype Modification?
Status: COMPLETED
Conditions: Gingival Phenotype
Interventions: PROCEDURE: Epithelialized free gingival graft|PROCEDURE: Modified coronally advanced tunnel technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Busulfan Safety/Efficacy as Conditioning Prior to Hematopoietic Cell Transplantation (HCT)
Status: COMPLETED
Conditions: Myelodysplastic Syndromes|Myeloproliferative Disorders|Leukemia, Lymphocytic|Myeloma|Lymphoma
Interventions: DRUG: Busulfan|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Dose-response "Pilot" Study of Topically Delivered Clobetasol Propionate Lotion in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Clobex TM (Clobetasol) 0.05% Lotion, single exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Stopping Cavities Study: Diammine Silver Fluoride
Status: COMPLETED
Conditions: Dental Caries
Interventions: DRUG: 38% diammine silver fluoride|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clarithromycin, Sulfamethoxazole/Trimethoprim or Observation in Newly Diagnosed Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma|Infection
Interventions: DRUG: Standard myeloma treatment|DRUG: Clarithromycin|DRUG: Sulfamethoxazole/trimethoprim|DRUG: Observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromodulation of Social Skills in Childhood Ataxia
Status: UNKNOWN
Conditions: Ataxia, Cerebellar
Interventions: DEVICE: Active-tDCS group|DEVICE: Sham-tDCS group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Travoprost 0.004% Versus Tafluprost 0.0015% in Patients With Primary Open-angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Travoprost 0.004% ophthalmic solution (TRAVATAN)|DRUG: Tafluprost 0.0015% ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Allogenic NK Cells in Combination With Chemotherapy in the Treatment of r/r AML After Allo-HSCT
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: allogenic NK cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a 10 Valent Pneumococcal Conjugate Vaccine (SIILPCV10) in Healthy Adults, Toddlers, Infants
Status: COMPLETED
Conditions: Pneumococcal Disease
Interventions: BIOLOGICAL: SIILPCV10|BIOLOGICAL: Pneumovax 23|BIOLOGICAL: Prevenar 13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dosing Flexibility Study in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Certolizumab pegol|DRUG: Certolizumab pegol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of an Investigational Drug in the Treatment of Postoperative Dental Pain (MK-2295-005)
Status: COMPLETED
Conditions: Pain, Postoperative|Tooth Extraction
Interventions: DRUG: MK2295
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BioClock: Bright Light Therapy for Depressive Disorders
Status: NOT_YET_RECRUITING
Conditions: Depression, Unipolar|Depression, Bipolar
Interventions: PROCEDURE: Bright Light Therapy|DEVICE: Blue Light Blocking Glasses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Orally Administered DS102 in Patients With Acute Alcoholic Hepatitis
Status: TERMINATED
Conditions: Severe Acute Decompensated Alcoholic Hepatitis
Interventions: DRUG: 1000mg DS102 (BID)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplementation With Altha-aminoacids and Systemiec Inflammatory Response in Long-distance Runners.
Status: NOT_YET_RECRUITING
Conditions: Exercise Myoglobinuria|Citrulline; Metabolic Disorder|Iron Metabolism Disorders|Inflammatory Response
Interventions: DIETARY_SUPPLEMENT: Alpha-amino acid derivatives
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cancer Genetic Testing in Ethnic Populations
Status: RECRUITING
Conditions: Breast Carcinoma|Carcinoma of Unknown Primary|Central Nervous System Carcinoma|Digestive System Carcinoma|Genitourinary System Carcinoma|Head and Neck Carcinoma|Malignant Brain Neoplasm|Malignant Female Reproductive System Neoplasm|Malignant Musculoskeletal Neoplasm|Malignant Solid Neoplasm|Skin Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Genetic Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study in Healthy Subjects to Assess Bioavailability (Proportion of a Drug Which Enters the Circulation to Have an Active Effect) of Acalabrutinib Tablet and Protonpump Inhibitor Effect (Members of a Class of Medications That Inhibits in Gastric Acid Production) for Rabeprazole
Status: COMPLETED
Conditions: Mantle Cell Lymphoma|COVID-19
Interventions: DRUG: Acalabrutinib Treatment A|DRUG: Acalabrutinib Treatment B|DRUG: Acalabrutinib Treatment C|DRUG: Acalabrutinib Treatment D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of AIN457 in Adults (18-65 Years) With Moderate to Severe Ankylosing Spondylitis
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: BIOLOGICAL: AIN457A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Total Skin Electron Beam Therapy (TSEBT 12 Gy) in Stage IB-IIIA Mycosis Fungoides
Status: TERMINATED
Conditions: Mycosis Fungoides|Lymphomas: Non-Hodgkin|Lymphomas: Non-Hodgkin Peripheral T-Cell|Lymphomas: Non-Hodgkin Cutaneous Lymphoma
Interventions: RADIATION: Total Skin Electron Beam Therapy (TSEBT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate Pharmacokinetics, Safety and Tolerability After a Single Dose Administration of of JNJ-31001074 in Children (6-11 Years) With Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder|Attention Deficit Disorders With Hyperactivity
Interventions: DRUG: JNJ-31001074
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Proprioceptive Abilities While Wearing an Elastic Orthosis in Patients With Proprioceptive Knee Deficits
Status: COMPLETED
Conditions: Proprioceptive Disorders
Interventions: DEVICE: proprioceptive knee brace|DEVICE: No knee brace
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CPI-613 and Bendamustine Hydrochloride in Treating Patients With Relapsed or Refractory T-Cell Non-Hodgkin Lymphoma or Hodgkin Lymphoma
Status: COMPLETED
Conditions: Adult Lymphocyte Depletion Hodgkin Lymphoma|Adult Lymphocyte Predominant Hodgkin Lymphoma|Adult Mixed Cellularity Hodgkin Lymphoma|Adult Nasal Type Extranodal NK/T-cell Lymphoma|Adult Nodular Sclerosis Hodgkin Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Hepatosplenic T-cell Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|T-cell Adult Acute Lymphoblastic Leukemia|T-cell Large Granular Lymphocyte Leukemia
Interventions: DRUG: 6,8-bis(benzylthio)octanoic acid|DRUG: bendamustine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Hypotension in Parturients With an Elevated Body Mass Index (BMI)
Status: COMPLETED
Conditions: Hypotension
Interventions: DRUG: Phenylephrine bolus|DRUG: phenylephrine infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CMAC® Versus Airtraq® and Macintosh Laryngoscope in Difficult Tracheal Intubation.
Status: TERMINATED
Conditions: Airway|Difficult Intubation|Airway Device
Interventions: DEVICE: macintosh laryngoscope|DEVICE: C-MAC laryngoscope|DEVICE: Airtraq device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Rilpivirine-based Regimens as Switch Therapy From Nevirapine-based Regimens in HIV-infected Patients
Status: COMPLETED
Conditions: Efficacy of Rilpivirine-based Regimens as Switch Therapy
Interventions: DRUG: Nevirapine|DRUG: Rilpivirine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics (PK) Evaluation of BZ371A, Topically Administered
Status: COMPLETED
Conditions: Erectile Dysfunction Following Radical Prostatectomy|Erectile Dysfunction|Prostate Cancer|Radical Prostatectomy
Interventions: DRUG: BZ371A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Normal Pressure Hydrocephalus and Sleep Apnea
Status: UNKNOWN
Conditions: Normal Pressure Hydrocephalus|Sleep Apnea|Cerebrospinal Fluid Shunt Occlusion
Interventions: PROCEDURE: CSF shunt diversion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The DINE Study-Diet Intervention to Negate Diabetes Study (Improving Weight Loss Outcomes for African Americans)
Status: COMPLETED
Conditions: Diabetes|Hypertension|Insulin Resistance
Interventions: BEHAVIORAL: The DASH diet with weight loss|BEHAVIORAL: The DASH diet without weight loss|BEHAVIORAL: Dairy diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: IDEAL Study: Blinded RCT for the Impact of AI Model for Cerebral Aneurysms Detection on Patients' Diagnosis and Outcomes
Status: NOT_YET_RECRUITING
Conditions: Intracranial Aneurysm|CT Angiography|Deep Learning|Double Bind Interaction
Interventions: DEVICE: True-AI-integrated intracranial aneurysms diagnosis strategy|DEVICE: Sham-AI-integrated intracranial aneurysms diagnosis strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Long-Term Feedback Effect of FGM in Newly-Diagnosed T2D Patients
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: DEVICE: flash glucose monitoring continuous|DIAGNOSTIC_TEST: capillary blood test|DEVICE: flash glucose monitoring intermittent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bone Particles Sizes and the Stability of Soft and Hard Tissue in Aesthetic Area
Status: ACTIVE_NOT_RECRUITING
Conditions: Implant Site Reaction
Interventions: DEVICE: Heterograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3841136 in Healthy and Overweight Participants
Status: COMPLETED
Conditions: Obesity|Healthy
Interventions: DRUG: LY3841136|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Acquisition and Utilization of Skills Using Innovative Smartphone Application for Regular Eating
Status: COMPLETED
Conditions: Bulimia Nervosa|Bulimia|Binge Eating|Purging|Eating Disorder
Interventions: BEHAVIORAL: CBT+ application
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of WU-NK-101 in Patients With Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML)
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: WU-NK-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison Study With Alendronate and Raloxifene in Postmenopausal Women With Osteoporosis (0217-189)
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal
Interventions: DRUG: MK0217, /Duration of Treatment : 12 Months|DRUG: Comparator : raloxifene hydrochloride /Duration of Treatment : 12 Months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fingolimod Versus Dimethyl-fumarate in Multiple Sclerosis
Status: TERMINATED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: Fingolimod|DRUG: Dimethyl Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Assessment of Meos Telemedicine E-portal on Ambulatory Care of Type 1 Diabetic Patients
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 1
Interventions: DEVICE: Meos ePortal use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase II Study to Evaluate the Safety and Efficacy of Prostatic Artery Embolization
Status: RECRUITING
Conditions: Prostate Carcinoma|Benign Prostatic Hyperplasia
Interventions: DEVICE: Merit Medical Embospheres|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ClariCore Optical Biopsy System Used in TRUS (Trans-Rectal Ultrasound)-Guided Prostrate Biopsy
Status: UNKNOWN
Conditions: Cellular Diagnosis, Prostate Cancer
Interventions: DEVICE: ClariCore System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Telmisartan vs. Valsartan in Patients With Mild to Moderate Hypertension Following a Missed Dose
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: telmisartan, valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety Study of Clindamycin Palmitate Hydrochloride Dispersible Tablet Treatment of Bacterial Vaginosis
Status: UNKNOWN
Conditions: Bacterial Vaginosis
Interventions: DRUG: Clindamycin palmitate hydrochloride dispersible tablet|DRUG: Metronidazole Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Caspase Inhibitor in Chronic Hepatitis C (HCV) Patients
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: IDN-6556|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Clinical Trial of OCH-NCNP1
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting|Multiple Sclerosis, Secondary Progressive
Interventions: DRUG: OCH-NCNP1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subpopulation-Specific Sepsis Identification Using Machine Learning
Status: WITHDRAWN
Conditions: Sepsis|Severe Sepsis|Septic Shock
Interventions: DIAGNOSTIC_TEST: CustomSight
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of CPI-613 for Patients With Relapsed or Refractory Burkitt Lymphoma/Leukemia or High-Grade B-Cell Lymphoma With High-Risk Translocations
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma|Leukemia
Interventions: DRUG: CPI-613
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Shock Wave Therapy and Assessment Strategy Through a Novel Gait Analysis Tool for Post-stroke Spasticity
Status: COMPLETED
Conditions: Stroke, Ischemic|Stroke Hemorrhagic|Spasticity, Muscle|Spastic Gait
Interventions: OTHER: Radial extracorporeal shock wave therapy and conventional physical therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Post-Operative Pain Control Using Direct Continuous Bupivacaine Infusion After Pelvic Organ Prolapse Repair
Status: UNKNOWN
Conditions: Post-Operative Pain|Pelvic Organ Prolapse
Interventions: DEVICE: Continuous bupivacaine analgesia infusion (ON-Q PainBuster Post-Op Pain Relief System)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study to Evaluate Therapeutic Ultrasound (TUS) to Acutely Increase the Perfusion in Peripheral Arterial Disease (PAD)
Status: RECRUITING
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: VibratoSleeve Therapeutic Ultrasound Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Sumatriptan and Placebo on Isosorbide-5-mononitrate Induced Headache
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: 5-ISMN (isosorbide-5-mononitrate)|DRUG: Sumatriptan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Immunogenicity of Vaccine Reimmunization With a Third Homologous Versus Heterologous Dose Against COVID-19 in Patients Undergoing Solid Organ Transplantation.
Status: WITHDRAWN
Conditions: Covid19
Interventions: BIOLOGICAL: Janssen vaccine|BIOLOGICAL: Spikevax (Moderna) vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Spatio-Temporal Gait Parameters and Gait Symmetry In Diabetic Lower Extremity Burn Injury.
Status: COMPLETED
Conditions: Diabetic Polyneuropathy|Foot Injuries
Interventions: DIAGNOSTIC_TEST: gait analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A First-in-human Study to Learn How Safe the Study Drug BAY3375968, an Anti-CCR8 Antibody, is, When Given Alone or in Combination With Pembrolizumab, How it Affects the Body, How it Moves Into, Through, and Out of the Body, and to Find the Best Dose in Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: BAY3375968|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Safety Study of Raltegravir and Atazanavir in a Once Daily Dose Regimen in HIV-1 Infected Patients
Status: COMPLETED
Conditions: HIV Infection|HIV Infections
Interventions: DRUG: raltegravir QD|DRUG: atazanavir|DRUG: lamivudine (or emtricitabine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Costs of the Patient's Stay Under ExtraCorporeal Membrane Oxygenation From the Hospital Point of View: a Pilot Study at the Rennes University Hospital Center
Status: COMPLETED
Conditions: ExtraCorporeal Membrane Oxygenation
Interventions: PROCEDURE: ExtraCorporeal Membrane Oxygenation (ECMO)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Long-term Safety of Lumacaftor/Ivacaftor in Subjects With Cystic Fibrosis Who Are Homozygous for F508del and 12 to <24 Months of Age at Treatment Initiation
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: LUM/IVA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telehealth Based Intervention to Improve Functional Capacity in Survivors of Childhood Cancer With Significantly Limited Exercise Tolerance
Status: RECRUITING
Conditions: Childhood Cancer|Mobility Limitation
Interventions: OTHER: Exercise testing results|OTHER: Individually tailored exercise program (INT)|OTHER: Generalized exercise recommendations (AC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Improving Drug Safety in Emergency Patients -a Randomized Controlled Trial
Status: COMPLETED
Conditions: Medication Compliance|Drug-Related Side Effects and Adverse Reactions|Remission|Medicinal Substance; Adverse Effect|Drug Interaction Potentiation
Interventions: OTHER: Medication reconciliation and medication review
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Facilitated Tucking and Gentle Human Touch on Procedural Pain Among Neonates
Status: RECRUITING
Conditions: Non Pharmacological Pain Management
Interventions: OTHER: Facilitated Tucking|OTHER: Gentle Human Touch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does Preference-based HIV Testing Increase Uptake in High Risk Populations?
Status: COMPLETED
Conditions: HIV Testing
Interventions: BEHAVIORAL: PB-HCT +|BEHAVIORAL: PB-HCT -|BEHAVIORAL: Economic incentive|BEHAVIORAL: PB-HCT ++|BEHAVIORAL: SMS Reminder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Vascularized Inter-positional Periosteal Connective-tissue Flap Versus Collagen Membrane in Guided Bone Regeneration
Status: RECRUITING
Conditions: Horizontal Ridge Deficiency
Interventions: PROCEDURE: Vascularized inter-positional periosteal connective tissue flap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immune and Recovery Modulating Impact of Probiotic Supplementation After Intense Resistance Exercise
Status: COMPLETED
Conditions: Immune Markers|Complete Blood Count (CBC) With Platelet Differentials|Muscle Damage|Muscular Force Production|Countermovement Jump|Muscular Fatigue|Muscular Soreness
Interventions: DIETARY_SUPPLEMENT: Active Probiotic Culture|DIETARY_SUPPLEMENT: Inactive Probiotic Culture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Mechanisms of Non-Invasive Neuromodulation Interventions: Influence on Human Neurochemistry and Functional Connectivity
Status: COMPLETED
Conditions: Non-invasive Neuromodulation in Healthy Subjects
Interventions: DEVICE: Inhibitory rTMS (1 Hz)|DEVICE: Excitatory rTMS (5 Hz)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Ibandronate (Bonviva) in Patients With Post-Menopausal Osteoporosis
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: Alendronate|DRUG: Ibandronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Concomitant Administration of ChAd63/MVA ME-TRAP + RTS,S
Status: COMPLETED
Conditions: Plasmodium Falciparum Malaria
Interventions: BIOLOGICAL: RTS,S/AS01B (50mcg of RTS,S and standard adult dose of AS01)|BIOLOGICAL: RTS,S/AS01B (10mcg of RTS,S and one fifth of the standard dose of AS01)|BIOLOGICAL: ChAd63 ME-TRAP (5 x 10^10 vp)|BIOLOGICAL: MVA ME-TRAP (2 x 10^8 pfu)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Onset Time of Nerve Block: A Comparison of Two Injection Locations in Patients Having Lower Leg/ Foot Surgery
Status: UNKNOWN
Conditions: Strain of Muscle and/or Tendon of Lower Leg|Fracture of Lower Leg|Crushing Injury of Lower Leg|Fracture Malunion - Ankle and/or Foot|Disorder of Joint of Ankle and/or Foot|Complete Tear, Ankle and/or Foot Ligament|Pathological Fracture - Ankle and/or Foot|Loose Body in Joint of Ankle and/or Foot
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Aerosolized Sargramostim Added to Immunotherapy for the Treatment of Patients With Metastatic Melanoma to the Lung
Status: NOT_YET_RECRUITING
Conditions: Clinical Stage IV Cutaneous Melanoma AJCC v8|Metastatic Malignant Neoplasm in the Lung|Metastatic Melanoma|Recurrent Melanoma|Unresectable Melanoma
Interventions: BIOLOGICAL: Aerosol Sargramostim|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|OTHER: Medical Device Usage and Evaluation|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ruxolitinib as First Line Treatment in Primary Haemophagocytic Lymphohistiocytosis (R-HLH)
Status: NOT_YET_RECRUITING
Conditions: Haemophagocytic Lymphohistiocytosis
Interventions: DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increasing Knowledge and Interest in Cancer Clinical Trials
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Web-based Educational Intervention|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Akt Inhibitor MK2206, Lapatinib Ditosylate, and Trastuzumab in Treating Patients With Locally Advanced or Metastatic HER2-Positive Breast , Gastric, or Gastroesophageal Cancer That Cannot Be Removed By Surgery
Status: TERMINATED
Conditions: Adenocarcinoma of the Gastroesophageal Junction|HER2-positive Breast Cancer|Male Breast Cancer|Recurrent Breast Cancer|Recurrent Esophageal Cancer|Recurrent Gastric Cancer|Stage IIIC Breast Cancer|Stage IIIC Esophageal Cancer|Stage IIIC Gastric Cancer|Stage IV Breast Cancer|Stage IV Esophageal Cancer|Stage IV Gastric Cancer
Interventions: DRUG: Akt inhibitor MK2206|BIOLOGICAL: trastuzumab|DRUG: lapatinib ditosylate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Community-based Mental Health Care for People With Severe and Enduring Mental Ill Health
Status: UNKNOWN
Conditions: Severe Mental Disorders|Schizophrenia|Bipolar Disorder|Severe Depression
Interventions: OTHER: CMHT|OTHER: CAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH