pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pemetrexed Disodium in Treating Patients With Recurrent Malignant Gliomas, Primary CNS Lymphoma, or Brain Metastases
Status: UNKNOWN
Conditions: Brain and Central Nervous System Tumors|Lymphoma|Metastatic Cancer
Interventions: DRUG: pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Magnetic Resonance (MR) to Understand the Effect of Erythromycin on Bowel Motility
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Erythromycin|DRUG: Placebo|PROCEDURE: Magnetic Resonance Imaging|OTHER: Barium Sulfate Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Exercise for Gut Microbiome in Patients With Young-Onset Colorectal Cancer Undergoing Chemotherapy: The COURAGE Trial
Status: RECRUITING
Conditions: Colorectal Cancer|Metastatic Colon Cancer|Metastatic Colorectal Cancer
Interventions: BEHAVIORAL: Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Skin Inflammation and PK of Azithromycin
Status: NOT_YET_RECRUITING
Conditions: Skin Infection
Interventions: DRUG: Azithromycin|DIAGNOSTIC_TEST: Biopsy|OTHER: Skin inflammation model
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Safety and Efficacy of Cerebrolysin in Patients With Acute Ischemic Stroke
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: Cerebrolysin|DRUG: 0.9% Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Bleeding in Total Joint Replacement: Combined Route Administration of Tranexamic Acid
Status: COMPLETED
Conditions: Tranexamic Acid|Arthroplasty, Replacement, Knee|Blood Transfusion|Arthroplasty, Replacement, Hip
Interventions: DRUG: Combined route administration of Tranexamic acid|DRUG: Intravenous route Tranexamic acid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2
Status: RECRUITING
Conditions: Stable Nonsegmental Vitiligo|Active Nonsegmental Vitiligo
Interventions: DRUG: Ritlecitinib|DRUG: Ritlecitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of VF Induction Techniques During Medtronic ICD Implant (VF) (ICD)
Status: COMPLETED
Conditions: Cardiomyopathy
Interventions: DEVICE: Nominal T shock setting|DEVICE: Educated T shock setting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Managing Pain and Cognitions in Older Adults With Mild Cognitive Impairment or Memory Related Problems and Chronic Pain
Status: COMPLETED
Conditions: Chronic Pain|Mild Cognitive Impairment|Older Adults|Physical Activity
Interventions: BEHAVIORAL: Active Brains 1|BEHAVIORAL: Active Brains 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Stroke Study: Operative Strategies to Reduce Cerebral Embolic Events During Coronary Artery Bypass Surgery
Status: COMPLETED
Conditions: Stroke
Interventions: PROCEDURE: No aortic clamping|PROCEDURE: partial occluding clamp|PROCEDURE: single cross clamp|PROCEDURE: cross clamp and partial occluding clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Cardiac Toxicity|Leukemia|Lymphoma
Interventions: DRUG: asparaginase|DRUG: cytarabine|DRUG: dexrazoxane hydrochloride|DRUG: doxorubicin hydrochloride|DRUG: leucovorin calcium|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: prednisone|DRUG: therapeutic hydrocortisone|DRUG: vincristine sulfate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Endorings™ Assisted Colonoscopy Versus Standard Colonoscopy for Polyp Detection
Status: COMPLETED
Conditions: Colorectal Neoplasia|Intestinal Neoplasms|Digestive Neoplasms|Digestive System Disease|Intestinal Disease|Gastrointestinal Disease|Gastrointestinal Neoplasm
Interventions: DEVICE: Standard colonoscopy|DEVICE: EndoRings™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Cardiac Output Autonomic Stimulation Therapy for Heart Failure (COAST-HF) - Human NeuroCatheter Study
Status: COMPLETED
Conditions: Cardiac Output, Low
Interventions: DEVICE: NeuroTronik CANS Therapy System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: The Use of LIFUP in Chronic Disorders of Consciousness
Status: COMPLETED
Conditions: Disorder of Consciousness|Vegetative State|Minimally Conscious State|Minimally Conscious State Plus|Minimally Conscious State Minus|Traumatic Brain Injury|CVA (Cerebrovascular Accident)|Anoxia, Brain|Thalamic Infarction|Coma; Prolonged
Interventions: DEVICE: BX Pulsar 1002 (LIFUP) Low intensity Focused Ultrasound Pulsation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: DCE-CT of Thoracic Tumors as an Early Biomarker for Treatment Monitoring in Comparison With Morphologic Criteria
Status: UNKNOWN
Conditions: Cancer, Lung|Perfusion Computed Tomography Target Lesion|Cancer Liver|Metastatic Lung Cancer|Metastatic Liver Cancer
Interventions: DEVICE: Extra DCE-CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Occupational Therapy Driving Intervention for Returning Combat Veterans.
Status: COMPLETED
Conditions: Traumatic Brain Injury (TBI)|Post Traumatic Stress Disorder (PTSD)
Interventions: BEHAVIORAL: Driving Behavior Interview|BEHAVIORAL: Fitness-to-Drive Screening Measure|OTHER: Clinical Driving Assessment|BEHAVIORAL: Propensity for Angry Driving Scale|BEHAVIORAL: Community Integration Questionnaire|BEHAVIORAL: Satisfaction with Life Questionnaire|PROCEDURE: Driving simulator evaluation|OTHER: Focus Group Discussion Interview Guide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lower Thoracic Epidural vs Erector Spinae Block for PNL
Status: NOT_YET_RECRUITING
Conditions: Percutaneous Nephrolithotomy
Interventions: PROCEDURE: Lower thoracic epidural|PROCEDURE: Erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Decreasing Propofol Injection Pain by Pre-Treatment With Lidocaine in Pediatric Procedural Sedation
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: Lidocaine|DRUG: Normal Saline|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Enteric Nervous System Using Colonic Biopsies in Parkinson Patients With LRRK2 Mutation
Status: TERMINATED
Conditions: Parkinson's Disease
Interventions: OTHER: colonoscopy or rectosigmoidoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immunomodulation With Eltrombopag in ITP
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Immune Thrombocytopenia (ITP)
Interventions: DRUG: Eltrombopag (Revolade®)|DRUG: standard therapy (without eltrombopag): HD-DXM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic-assisted Distal Gastrectomy and Totally Laparoscopic Distal Gastrectomy for Gastric Cancer
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: PROCEDURE: laparoscopy-assisted distal gastrectomy Group|PROCEDURE: Totally laparoscopic distal gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor Peripheral Stem Cell Transplant and Donor Natural Killer Cell Transplant After Total-Body Irradiation, Thiotepa, Fludarabine, and Muromonab-CD3 in Treating Patients With Leukemia or Other Blood Diseases
Status: TERMINATED
Conditions: Graft Versus Host Disease|Leukemia|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: muromonab-CD3|BIOLOGICAL: natural killer cell therapy|DRUG: fludarabine phosphate|DRUG: methotrexate|DRUG: thiotepa|GENETIC: gene expression analysis|OTHER: flow cytometry|OTHER: immunologic technique|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: in vitro-treated peripheral blood stem cell transplantation|RADIATION: total-body irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analysis of Myocardial Layer Specific Systolic and Diastolic Function During and After PCI
Status: COMPLETED
Conditions: Percutaneous Coronary Intervention|Myocardial Ischemia|Anginal Pain
Interventions: PROCEDURE: Percutaneous Coronary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Performance of Posterior Indirect Adhesive Restorations
Status: UNKNOWN
Conditions: Dental Caries|Endodontically Treated Teeth|Dental Restoration Failure of Marginal Integrity|Wear, Occlusal
Interventions: DEVICE: Indirect adhesive restoration of posterior teeth
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetic Study of Dapivirine Gel (0.05%) Administered Rectally to HIV-1 Seronegative Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Dapivirine gel|DRUG: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study on the Mechanism of Regulating Gut Microbiome in Obese People by Regulating Brain-gut Axis With Fast Diet
Status: COMPLETED
Conditions: Obesity|Gastrointestinal Microbiome|Magnetic Resonance Imaging
Interventions: OTHER: Fast diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phrenic Identification in the ICU
Status: NOT_YET_RECRUITING
Conditions: Ventilator Lung|Ventilator-Induced Lung Injury|Diaphragm Disease|Phrenic Nerve|Phrenic Nerve Stimulation|Neck Anatomy|Ultrasound
Interventions: PROCEDURE: Neck ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neurokinin-1 Receptor Antagonist for the Treatment of Itch in EB Patients
Status: COMPLETED
Conditions: Epidermolysis Bullosa|Pruritus
Interventions: DRUG: VPD-737|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Effects of INL1 in Patients With Heart Failure and Reduced Ejection Fraction
Status: UNKNOWN
Conditions: Heart Failure|Reduced Ejection Fraction
Interventions: DRUG: INL1|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OLP to Manage Pain in TJA: A Feasibility Study
Status: WITHDRAWN
Conditions: Opioid Dependence|Opioid Abuse
Interventions: DRUG: Open Label Placebo|DRUG: Patient medication as standardly prescribed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Microbial Colonization of Oral Probiotics
Status: UNKNOWN
Conditions: Microbial Colonization
Interventions: DIETARY_SUPPLEMENT: Streptococcus salivarius K12 lozenge|DIETARY_SUPPLEMENT: Probiotic S. salivarius K12 lozenges containing prebiotic A|DIETARY_SUPPLEMENT: Probiotic S. salivarius K12 lozenges containing prebiotic B|DIETARY_SUPPLEMENT: Probiotic S. salivarius K12 lozenges containing prebiotics A and B|DIETARY_SUPPLEMENT: Probiotic S. salivarius K12 powder|DIETARY_SUPPLEMENT: Probiotic S. salivarius K12 powder containing prebiotic A|DIETARY_SUPPLEMENT: Probiotic S. salivarius K12 powder containing prebiotic B|DIETARY_SUPPLEMENT: Probiotic S. salivarius K12 powder containing prebiotics A and B|DIETARY_SUPPLEMENT: Probiotic S. salivarius M18 lozenges|DIETARY_SUPPLEMENT: Probiotic S. salivarius M18 lozenges containing prebiotic A|DIETARY_SUPPLEMENT: Probiotic S. salivarius M18 lozenges containing prebiotic B|DIETARY_SUPPLEMENT: Probiotic S. salivarius M18 + lozenges containing prebiotic A and B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Preservative-free Low-dose Hyaluronic Acid-containing Salt Solution on Dry Eye Disease
Status: UNKNOWN
Conditions: Dry Eye
Interventions: DRUG: salt solution without 0.15% HA|DRUG: preservative-free 0.15% HA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial on the Treatment of Idiopathic Pulmonary Fibrosis
Status: NOT_YET_RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: TDI01 suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Classical Miller, Wis-Hipple and C-MAC Size 1 Blades
Status: COMPLETED
Conditions: Percent of Glottic Opening
Interventions: DEVICE: Laryngoscope blade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Therapeutic Equivalence of Two Formulations of Fluticasone Propionate and Salmeterol Inhalation Powder in Subjects With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone Propionate and Salmeterol Inhalation Powder|DRUG: Fluticasone Propionate and Salmeterol Inhalation Powder|DRUG: Placebo Inhalation Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tadalafil in Subjects With Erectile Dysfunction Caused by Spinal Cord Injury
Status: COMPLETED
Conditions: Erectile Dysfunction|Spinal Cord Injuries
Interventions: DRUG: tadalafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Cutaneous Lupus Erythematosus and Elidel
Status: WITHDRAWN
Conditions: Lupus Erythematosus, Cutaneous|Lupus Erythematosus, Discoid
Interventions: DRUG: Elidel (pimecrolimus)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Yellow Cassava to Improve Vitamin A Status of Kenyan School Children
Status: COMPLETED
Conditions: Vitamin A Deficiency
Interventions: OTHER: Yellow cassava|OTHER: White cassava|OTHER: White cassava
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Study on the Acceptability of Auricular Vagus Nerve Neurostimulation in Adolescents
Status: NOT_YET_RECRUITING
Conditions: Psychiatric Disorder
Interventions: DEVICE: transcutaneous auricular vagal nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Possible Role of Gingival Crevicular Fluid Levels of Chemerin and Fibroblast Growth Factor 21 as Biomarkers of Periodontal Disease in Diabetic and Non-diabetic Patients
Status: COMPLETED
Conditions: Periodontal Disease (Diagnosis)|Diabetes Mellitus, Type 2
Interventions: DIAGNOSTIC_TEST: gingival crevicular fluid level
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate fMRI of Active DBS Stimulation in Epilepsy
Status: WITHDRAWN
Conditions: Refractory Epilepsy
Interventions: DIAGNOSTIC_TEST: Functional magnetic resonance imaging (fMRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial of Motexafin Gadolinium and Pemetrexed (Alimta®) for Second Line Treatment in Patients With Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-Small Cell Lung Carcinoma
Interventions: DRUG: Motexafin gadolinium and pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparator Trial on the Relative Efficacy of Two Triglyceride Forms of Fish Oil
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Fish Oil|DIETARY_SUPPLEMENT: Fish Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Safety Study of Itacitinib (INCB039110) in Combination With Gemcitabine and Nab-Paclitaxel in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors|Pancreatic Cancer
Interventions: DRUG: itacitinib|DRUG: Gemcitabine|DRUG: nab-paclitaxel|DRUG: filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ATrial Tachycardia PAcing Therapy in Congenital Heart
Status: RECRUITING
Conditions: Atrial Arrhythmia|Atrial Tachycardia|Congenital Heart Disease|Pacemaker Re-Entrant Tachycardia
Interventions: DEVICE: Medtronic
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: FMT With Nivolumab in Patients With Advanced Solid Cancers Who Have Progressed During Anti-PD-(L)1 Therapy
Status: NOT_YET_RECRUITING
Conditions: Solid Carcinoma
Interventions: OTHER: fecal microbiota transplantation with Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Outcome Between Mycobacterium Abscessus Infection in Chronic Lung Disease and Acquired Interferon-gamma Autoantibody Syndrome
Status: COMPLETED
Conditions: Mycobacterium Abscessus Infection|Adult-Onset Immunodeficiency With Acquired Anti-Interferon-Gamma Autoantibodies|Nontuberculous Mycobacterial Pulmonary Infection
Interventions: DRUG: Appropriate treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bortezomib in Treating Patients With Advanced Cancer and Kidney Dysfunction
Status: COMPLETED
Conditions: Adult Grade III Lymphomatoid Granulomatosis|Adult Nasal Type Extranodal NK/T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Refractory Multiple Myeloma|Splenic Marginal Zone Lymphoma|Stage III Multiple Myeloma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific|Waldenström Macroglobulinemia
Interventions: DRUG: bortezomib|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Next Leap in Cardiac Magnetic Resonance Imaging:Cycling the Field
Status: RECRUITING
Conditions: Myocardial Infarction
Interventions: PROCEDURE: Cardiac Magnetic Resonance Imaging|PROCEDURE: Fast Field Cycling - Magnetic Resonance Imaging|PROCEDURE: Electrocardiogram|PROCEDURE: Echocardiogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination of Light and Ultrasound to Reduce Abdominal Fat
Status: COMPLETED
Conditions: Subcutaneous Fat Disorder
Interventions: DEVICE: Photobiomodulation (PBM) with infrared LED|DEVICE: Low-frequency ultrasound (LOFU)|DEVICE: Muscle electrostimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaporized Cannabis and Spinal Cord Injury Pain
Status: COMPLETED
Conditions: Spinal Cord Injuries|Spinal Cord Diseases
Interventions: DRUG: Vaporization of Cannabis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy With or Without Chemotherapy in Treating Patients With High-Risk Malignant Salivary Gland Tumors That Have Been Removed By Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer
Interventions: DRUG: cisplatin|RADIATION: 3-dimensional conformal radiation therapy|RADIATION: intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of the Relation Between Different Questionnaires Measuring Radiation-induced Side-effect
Status: ACTIVE_NOT_RECRUITING
Conditions: Radiation
Interventions: OTHER: MDASI-HN|OTHER: EORTC QLQ-C30|OTHER: EORTC HN35
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sexual Counseling According to the PLISSIT Model in Primary Infertile Couples
Status: UNKNOWN
Conditions: Infertility|Sexuality|Sexual Dysfunction|Nurse's Role|Infertility; Female|Infertility, Male
Interventions: OTHER: sexaul counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study on the Use of Micropulse Laser to Treat Central Serous Chorioretinopathy
Status: TERMINATED
Conditions: Central Serous Chorioretinopathy
Interventions: DEVICE: Micropulse Laser Treatment|OTHER: No treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Advanced Adenocarcinoma of Stomach and Gastroesophageal Junction With Camrelizumab+SOX Control Camrelizumab+SOX+ Trastuzumab
Status: RECRUITING
Conditions: Advanced Gastric Adenocarcinoma
Interventions: DRUG: camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Investigate the Safety, Tolerability and Pharmacokinetics of BV100 in Male Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: BV100|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective, Randomized Clinical Investigation of Two Different Postoperative Wound Dressings
Status: COMPLETED
Conditions: Hip Surgery Corrective|Knee Injuries
Interventions: DEVICE: Active Comparator: Aquacel Surgical|DEVICE: Experimental: Mepilex Border Post-Op
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Criteria for Advanced Prosthetic Foot Prescription
Status: ACTIVE_NOT_RECRUITING
Conditions: Prosthesis User|Amputation; Traumatic, Limb, Lower
Interventions: DEVICE: ESR Prosthetic Foot First|DEVICE: Articulating ESR Prosthetic Foot First|DEVICE: Powered Prosthetic Foot First
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TLK286 (Telcyta) in Combination With Cisplatin for Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: TLK286, cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin C to Chemotherapy Related Anemia in Pancreatic Cancer
Status: RECRUITING
Conditions: Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: Ascorbate|DRUG: Nab paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnesium Treatment on Vitamin D Metabolism in Participants Completed Personalized Prevention of Colorectal Cancer Trial
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: Magnesium glycinate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Preoperative Chewing Gum and Postoperative Nausea and Vomiting
Status: NOT_YET_RECRUITING
Conditions: Gynecologic Disease
Interventions: OTHER: Chewing sugar-free gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biological Response of Stage IV Knee Osteoarthritis to Serial 12.5% Dextrose
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: Dextrose intraarticularly administered
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sepantronium Bromide for the Treatment of High-grade B-cell Lymphoma
Status: RECRUITING
Conditions: High-grade B-cell Lymphoma|Burkitt Lymphoma|Lymphoma, B-Cell|Lymphoma, Large B-Cell, Diffuse|Lymphatic Diseases|Lymphoma, High-Grade|C-MYC/BCL2 Double-Hit High-Grade B-Cell Lymphoma|C-MYC/BCL6 Double-Hit High-Grade B-Cell Lymphoma|C-Myc Gene Rearrangement
Interventions: DRUG: Sepantronium Bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraneural Facilitation as a Treatment for Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: OTHER: Intraneural facilitation (INF)|OTHER: Sham INF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab Combined With Consolidation Radiotherapy After First-line Treatment in Extensive Stage Small Cell Lung Cancer With Oligometastases
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer|Extensive-stage Small-cell Lung Cancer|Radiotherapy
Interventions: DRUG: Durvalumab + carboplatin/cisplatin + etoposide|RADIATION: Consolidation radiotherapy|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Hypoglycemia After Exercise Using Closed Loop System in Children and Adolescents With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: DreaMed Substance Administration Device|DEVICE: Sensor Augmented Pump (SAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endurance Exercise & Virtual Reality for Optimizing Cortical Excitability and Neuroplasticity in PD
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: High intensity endurance exercise|BEHAVIORAL: Stretching exercise|BEHAVIORAL: Virtual reality (VR)-based gaming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of GABA Enhancing Medications on Individuals Addicted to Cocaine - 3
Status: TERMINATED
Conditions: Cocaine Abuse|Cocaine-Related Disorders
Interventions: DRUG: Pregabalin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunization of Children Between 8 Weeks and 2 Years of Age With GSK Pneumococcal Vaccine GSK1024850A
Status: COMPLETED
Conditions: Infections, Streptococcal
Interventions: BIOLOGICAL: GSK1024850A (Synflorix)|BIOLOGICAL: Tritanrix-HepB/Hib|BIOLOGICAL: Polio Sabin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Multicentre Clinical Study of Ultra-Fast-Track Anaesthesia for Minimally Invasive Heart Valve Surgery
Status: NOT_YET_RECRUITING
Conditions: Heart Valve Diseases|Enhanced Recovery After Surgery
Interventions: PROCEDURE: Ultra-Fast-Track Cardiac Anesthesia(UFTCA)|PROCEDURE: conventional general anesthesia (CGA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Determine the Safety and Efficacy of Influenza Virus Vaccine, Trivalent, Types A & B, Live Cold- Adapted (CAIV-T) in Healthy Children Attending Day Care Centers
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: CAIV-T|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Cervical Cancer Screening Based on First-void Urine Self-sampling to Reach un(Der)-Screened Women: ScreenUrSelf Trial
Status: RECRUITING
Conditions: Cervix Cancer|Cervical Intraepithelial Neoplasia|Human Papilloma Virus|HPV-Related Cervical Carcinoma
Interventions: DEVICE: Colli-Pee Small Volumes|DEVICE: Evalyn Brush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Prognostic Value of Limited Transthoracic Echocardiogram (LTTE) During Trauma Resuscitation
Status: UNKNOWN
Conditions: Patients Who Are in Shock and Intubated in the Trauma Bay (TB)
Interventions: DEVICE: Limited Transthoracic Echocardiogram (LTTE, SonoSite Ultrasound)|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Melatonin Cream Against Acute Radiation Dermatitis in Patients With Early Breast Cancer
Status: COMPLETED
Conditions: Radiation Dermatitis|Radiation Dermatitis Acute|Breast Cancer
Interventions: DRUG: Melatonin|DRUG: Dimethyl Sulfoxide|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: DZD9008 In Combination With Bevacizumab in Locally Advanced or Metastatic NSCLC Patients With EGFR Mutation (WU-KONG29)
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: DZD9008 plus Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Continuous Intravenous Lidocaine Infusion Versus ESP Block for Rib Fracture Analgesia
Status: NOT_YET_RECRUITING
Conditions: Rib Fractures
Interventions: DRUG: Lidocaine IV Infusion|DRUG: 2% Lidocaine via ESPB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Probiotic Intervention on Intestinal Permeability
Status: COMPLETED
Conditions: Intestinal Permeability
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Transcranial Direct Current Stimulation (tDCS) on Depression in PD
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: DEVICE: transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Efficacy of a Single Intra-articular Injection of HYALUBRIX 60 in Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DEVICE: HYALUBRIX 60
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calcium Chloride for Prevention of Uterine Atony During Cesarean
Status: COMPLETED
Conditions: Uterine Atony|Uterine Atony With Hemorrhage|Cesarean Section Complications
Interventions: DRUG: Calcium Chloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Novel Blood Test to Predict Safe Foods for Infants and Toddlers With Food Protein-induced Enterocolitis Syndrome (FPIES)
Status: COMPLETED
Conditions: Food Protein-Induced Enterocolitis Syndrome|Allergies|Pediatric Disorder
Interventions: DIAGNOSTIC_TEST: Blood test assay
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Randomized, Multiple Dose, Double Blind, 5-way Crossover Study of the Electrocardiographic (ECG) Effects of Bilastine
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: bilastine|DRUG: Bilastine|DRUG: Bilastine & Ketoconazole|DRUG: Moxifloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of a Brief Motivational Interview on Drinking Behaviors of At Risk Drinkers Screened in the Emergency Room
Status: COMPLETED
Conditions: Alcohol Abuse
Interventions: BEHAVIORAL: Screening and Brief Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Hypofractionation Radiotherapy for Thymic Epithelial Tumours After Complete Resection
Status: RECRUITING
Conditions: Thymus Neoplasms
Interventions: RADIATION: Adjuvant Hypofractionation Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Community-Engaged Research: A Tool to Advance Cookstove Interventions
Status: COMPLETED
Conditions: Blood Pressure|Inflammation
Interventions: OTHER: Cleaner cookstove received after visit 2|OTHER: Cleaner cookstove received after visit 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Project HERMITAGE: HIV Prevention in Hospitalized Russian Drinkers
Status: COMPLETED
Conditions: HIV Infections
Interventions: BEHAVIORAL: Individual and group HIV risk behavior counseling sessions|BEHAVIORAL: health education and support group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Melatonin Dose-effect Relation in Childhood Autism
Status: COMPLETED
Conditions: Childhood Autism
Interventions: DRUG: melatonin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgery Before Embryo Transfer in ERROR (Endometrioma Related Reduction in Ovarian Reserve)
Status: UNKNOWN
Conditions: Endometriosis Related Infertility
Interventions: PROCEDURE: Laparoscopic Endometriosis Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Vitamin D Supplementation on SOD,IL-6 and Insulin Resistance in Type 2 Diabetes Mellitus (DM)
Status: ACTIVE_NOT_RECRUITING
Conditions: Type2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Vitamin D 5000 IU|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of AUY922 for GIST(Gastrointestinal Stromal Tumor) Patients
Status: UNKNOWN
Conditions: Gastrointestinal Stromal Tumor
Interventions: DRUG: AUY922
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Factor VIIa in Acute Intracerebral Haemorrhage
Status: COMPLETED
Conditions: Acquired Bleeding Disorder|Intracerebral Haemorrhage
Interventions: DRUG: eptacog alfa (activated)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Dose Escalation Study to Assess the Safety and Tolerability of ASP9853 With Either Docetaxel or Paclitaxel in Patients With Advanced Non-hematologic Malignancies
Status: TERMINATED
Conditions: Pharmacokinetics of ASP9853|Non-hematologic Malignancies
Interventions: DRUG: ASP9853|DRUG: Docetaxel|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Health Literacy - Neurocognitive Screening in Pediatric SCD
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: BEHAVIORAL: Passport Card|BEHAVIORAL: No Passport card
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Hyperbaric Oxygen Therapy (HBOT) as a Treatment for COVID-19 (COVID-19) Infection
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DEVICE: Hyperbaric Oxygen Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Caudal Block Versus Dorsal Penile Nerve Block Plus Ring Block for Pain Management of Different Surgical Techniques of Circumcision in Infants and Children
Status: UNKNOWN
Conditions: Anesthesia|Anesthesia, Local|Analgesia|Pediatric ALL|Pain, Postoperative|Pain, Acute
Interventions: DRUG: Caudal block|DRUG: Dorsal penile nerve block plus ring block|PROCEDURE: Circumcision with Plastibell|PROCEDURE: Conventional Dissection Method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of GSK Biologicals' Meningococcal Vaccine (GSK134612) and Licensed MenC-CRM197 Vaccine in Healthy Children
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: GSK Biologicals' meningococcal vaccine GSK134612|BIOLOGICAL: Menjugate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Docetaxel With Either Cetuximab or Bortezomib as First-Line Therapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Lung|Adenosquamous Cell Lung Cancer|Large Cell Lung Cancer|Malignant Pleural Effusion|Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: DRUG: docetaxel|BIOLOGICAL: cetuximab|DRUG: bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effect of Transcranial Magnetic Stimulation on Memory Impairment in Patients After Stroke
Status: WITHDRAWN
Conditions: Stroke|Stroke Sequelae|Cognitive Impairment
Interventions: DEVICE: theta burst stimulation|DEVICE: sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Home-Based or Clinic-Based Human Papillomavirus (HPV) Screening
Status: COMPLETED
Conditions: Atypical Squamous Cell of Undetermined Significance|Cervical Carcinoma|Cervical Intraepithelial Neoplasia Grade 2/3|Health Status Unknown|Human Papillomavirus Infection|Low Grade Cervical Squamous Intraepithelial Neoplasia|Stage 0 Cervical Cancer
Interventions: OTHER: Cervical Papanicolaou Test|OTHER: Cytology Specimen Collection Procedure|OTHER: Questionnaire Administration|PROCEDURE: Screening Method|PROCEDURE: Screening Method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Postoperative Telehealth Mindfulness Intervention After Spine Surgery
Status: COMPLETED
Conditions: Chronic Low-back Pain|Postsurgical Pain|Opioid Use|Lumbar Spine Surgery
Interventions: BEHAVIORAL: Individual telehealth mindfulness|BEHAVIORAL: Group telehealth mindfulness
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Screening Test Accuracy of Gynocular™, HR-HPV Testing, VIA for Detection of Cervical Neoplastic Lesions, in Women Living With HIV
Status: UNKNOWN
Conditions: Uterine Cervical Neoplasms|HIV/AIDS
Interventions: DIAGNOSTIC_TEST: Screening for CIN2+/HSIL
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Quadratus Lumborum Block After Cytoreductive Surgery and Hyperthermic Intra-peritoneal Chemotherapy
Status: RECRUITING
Conditions: Cytoreductive Surgery|Hyperthermic Intra-peritoneal Chemotherapy|Peritoneal Cancer
Interventions: PROCEDURE: Arm I (QL block and multimodal analgesia), Arm II (multimodal analgesia without regional block)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Subchondral Perfusion Mapping Using Indocyanin Green Laser
Status: TERMINATED
Conditions: Distal Femoral|Proximal Tibial|Knee Surgery
Interventions: DIAGNOSTIC_TEST: Indocyanin Green Dye (ICG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Performance of OrbiSymm in Subjects Referred to Contra Lateral Breast Symmetrisation
Status: UNKNOWN
Conditions: Breast Asymmetry Between Native Breast and Reconstructed Breast
Interventions: DEVICE: OrbiSymm device|PROCEDURE: Breast symmetrisation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity of Three HIV GTU® MultiHIV DNA Immunisations Administered Via Intramuscular, Intradermal and Transcutaneous Routes
Status: UNKNOWN
Conditions: HIV
Interventions: BIOLOGICAL: GTU®-multiHIV B clade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of ChOline ALfoscerate in Patient With Mild to Moderate Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: Choline Alfoscerate 400mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoepitope-based Personalized DNA Vaccine Approach in Pediatric Patients With Recurrent Brain Tumors
Status: RECRUITING
Conditions: Pediatric Recurrent Brain Tumor
Interventions: BIOLOGICAL: Personalized neoantigen DNA vaccine|DEVICE: Papivax Biotech TDS-IM v2.0|PROCEDURE: Peripheral blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MR-based Characterization of Bone Marrow in Its Relevance to Skeletal Disease in Patients With Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2|Osteoporosis|Insulin Resistance
Interventions: DIAGNOSTIC_TEST: magnetic resonance examination, anthropometric and metabolic characterization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p