pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of MK-3475 Alone or in Combination With Copanlisib in Relapsed or Refractory NK and T-cell Non-Hodgkin Lymphoma
Status: TERMINATED
Conditions: Lymphoma, T-Cell, Peripheral
Interventions: DRUG: MK-3475|DRUG: Copanlisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Respiratory Therapy in COPD Exacerbations
Status: COMPLETED
Conditions: Obstructive Chronic Bronchitis With Acute Exacerbation
Interventions: OTHER: No Respiratory Therapy|OTHER: Respiratory Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Does Ultrasound Improve Procedural Time in the Lateral Popliteal Approach to the Sciatic Nerve in Obese Patients
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Ultrasound|PROCEDURE: Nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot: Mind Over Matter: Healthy Bowels, Healthy Bladder
Status: COMPLETED
Conditions: Urinary Incontinence|Fecal Incontinence|Accidental Bowel Leakage
Interventions: BEHAVIORAL: Mind Over Matter; Healthy Bowels, Healthy Bladder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Transcutaneous Auricular Electroacupuncture on Sleep Disturbances in Patients With Rheumatoid Arthritis: A Randomized Double-Blind Clinical Trial
Status: RECRUITING
Conditions: Transcutaneous Electric Nerve Stimulation|Rheumatoid Arthritis|Sleep Quality
Interventions: DEVICE: Transcutaneous Auricular Vagus Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ORal Antibiotics In Acute Mesenteric Ischemia
Status: NOT_YET_RECRUITING
Conditions: Acute Mesenteric Ischemia
Interventions: DRUG: Gentamicin|DRUG: Placebo|DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Bioequivalence Between Brivaracetam Tablet and Dry Syrup in Healthy Male Japanese Study Participants
Status: COMPLETED
Conditions: Healthy Study Participants
Interventions: DRUG: brivaracetam|DRUG: brivaracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Prognostic Value of PGF and sFlt1 Variations Induced by the First Low-molecular-weight-heparin Injections in Women With Obstetrical Antiphospholipids Antibody Syndrome Starting a New Pregnancy and Following Treatment in Accordance With International Recommendations
Status: COMPLETED
Conditions: Antiphospholipid Syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Interaction of Alcohol and Highly Active Antiretroviral Therapy (HAART) in HIV/AIDS and HIV/AIDS With Hepatitis C Virus (HCV) Co-Infection
Status: COMPLETED
Conditions: HIV Infections|Hepatitis C
Interventions: DRUG: Alcohol|DRUG: Alcohol placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy
Status: RECRUITING
Conditions: Neuroblastoma|Diffuse Intrinsic Pontine Glioma
Interventions: BIOLOGICAL: Tumor-specific ex vivo expanded autologous lymphocyte transfer (TTRNA-xALT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bilateral Versus Unilateral Strength Training After ACLR
Status: WITHDRAWN
Conditions: Anterior Cruciate Ligament Injuries|Atrophy, Muscular|Anterior Cruciate Ligament Rupture|Anterior Cruciate Ligament Tear
Interventions: BEHAVIORAL: Resistance exercise program- UL|BEHAVIORAL: Resistance exercise program- BL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Organic Anion Transporting Polypeptide1B1(OATP1B1) Genotype on Rosuvastatin PK, PD and Lipid Profiles
Status: COMPLETED
Conditions: Organic Anion Transporting Polypeptide1B1 (OATP1B1)|Rosuvastatin
Interventions: DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Quality of Life After Nylon Darn Repair of Inguinal Hernia to Polypropylene Mesh Repair
Status: UNKNOWN
Conditions: Hernia, Inguinal|Hernia Direct|Hernias Indirect|Quality of Life
Interventions: PROCEDURE: inguinal hernia repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Pharmacokinetics and Preliminary Efficacy of Asimadoline in Pruritus Associated With Atopic Dermatitis
Status: COMPLETED
Conditions: Pruritus|Atopic Dermatitis
Interventions: DRUG: Asimadoline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Ibrutinib and Rituximab in Treatment Naïve Follicular Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Follicular Lymphoma
Interventions: DRUG: ibrutinib|DRUG: placebo to match ibrutinib|DRUG: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comprehensive ONline Program for Cognitive Enhancement, Reassurance and Training
Status: UNKNOWN
Conditions: Cognition Disorders in Old Age|Lifestyle, Healthy|Diet, Healthy|Exercise
Interventions: OTHER: Healthy lifestyle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase I Study of High-dose L-methylfolate in Combination With Temozolomide and Bevacizumab in Recurrent High Grade Glioma
Status: COMPLETED
Conditions: Malignant Glioma
Interventions: DRUG: Bevacizumab|DRUG: Temozolomide|DIETARY_SUPPLEMENT: Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of L-Dihydroxyphenylserine (L-DOPS) on Falls in Patients With Neurogenic Orthostatic Hypotension (NOH)
Status: UNKNOWN
Conditions: Parkinson Disease|Falls Patient
Interventions: DRUG: Droxidopa|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Telemonitoring-supported Game-based Home Exercises in Juvenile Idiopathic Arthritis
Status: COMPLETED
Conditions: Exercise Therapy|Juvenile Idiopathic Arthritis
Interventions: OTHER: Game-based telerehabilitation exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes Following Treatment With Systane® Balance in Dry Eye Subjects
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Propylene Glycol, 0.6% eye drops|DRUG: Preservative-free 0.9% Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, 3 Day Study of Safety and Tolerability of NVN1000 Topical Gel in Healthy Volunteers
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Topical Gel Vehicle|DRUG: 8% NVN1000 Topical Gel|DRUG: 8% NVN1000 Topical Gel and moisturizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b Study of MEDI4736 in Combination With Tremelimumab in Subjects With Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: NSCLC|Non-small Cell Lung Cancer|Lung Cancer
Interventions: DRUG: MEDI4736|DRUG: Tremelimumab|DRUG: tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flipped Learning Model on Nursing Students' Thorax and Heart Examination
Status: NOT_YET_RECRUITING
Conditions: Nursing Students|Nursing Caries|Nurse's Role
Interventions: OTHER: Flipped Learning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Manualized Assessment and Treatment Model of Challenging Behavior
Status: RECRUITING
Conditions: Problem Behavior|Aggression|Self-Injury
Interventions: BEHAVIORAL: Functional Communication Training (FCT)|BEHAVIORAL: Non-Contingent Reinforcement (NCR)|BEHAVIORAL: Competing Items and Response Blocking|BEHAVIORAL: Research Units in Behavioral Intervention (RUBI) protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Various Effects of Gaseous Albuterol on Serum Lactate
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Normal Saline|DRUG: Albuterol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bioequivalence Study of Torrent Pharmaceutical Limited's Isosorbide Mononitrate 120 mg ER Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Torrent's Isosorbide Mononitrate 120 mg ER Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Wedge NC - Scoring Balloon Dilatation Catheter
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Wedge NC Scoring Balloon Dilatation Catheter|DEVICE: Scoreflex Scoring Balloon Dilatation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Two Durations of Antibiotherapy for Non-surgically-treated Diabetic Foot Osteomyelitis (CHRONOS-2)
Status: NOT_YET_RECRUITING
Conditions: Osteomyelitis - Foot
Interventions: DRUG: Reduction in the duration of antibiotic therapy 3 weeks or 6 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity, Safety and Optimal Dose Finding Study of Recombinant Influenza H5N1 Vaccine in Healthy Young Adults
Status: COMPLETED
Conditions: Influenza|Virus Diseases
Interventions: BIOLOGICAL: UMN-0501|BIOLOGICAL: UMN-0501|BIOLOGICAL: UMN-0501
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Breathing Training for Improving Cardiovascular Health in Older Adults With Sleep Apnea
Status: RECRUITING
Conditions: Obstructive Sleep Apnea|Hypertension
Interventions: BEHAVIORAL: Inspiratory Muscle Strength Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Suture Anchor Comparison in Rotator Cuff Repairs
Status: COMPLETED
Conditions: Rotator Cuff Injury
Interventions: DEVICE: Suture Anchor HEALOCOIL|DEVICE: Suture anchor Twinfix Ultra HA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Tislelizumab in Participants With Resectable Esophageal Squamous Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Resectable Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Labor Induction After Cesarean Section: Outcome, Hormonal Trends
Status: COMPLETED
Conditions: Induction of Labor|Previous Cesarean Section|Hormonal Changes
Interventions: DEVICE: induction of labor by breast stimulation|DEVICE: induction of labor by catheter balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Repeatability in Hyperpolarized 3-Helium With MRI
Status: COMPLETED
Conditions: Radiation Exposure
Interventions: DRUG: Prone hyperpolarized 3 helium gas scan|DRUG: Supine hyperpolarized 3 helium gas scan|DIAGNOSTIC_TEST: Vitals|DIAGNOSTIC_TEST: Pulmonary Function Tests|DIAGNOSTIC_TEST: Initial protocol MRI scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Adapting Tools to Implement Stroke Risk Management to Veterans
Status: COMPLETED
Conditions: Ischemic Stroke|Transient Ischemic Attack
Interventions: BEHAVIORAL: Physician stroke guideline adherence|BEHAVIORAL: Stroke Self Management|OTHER: Attention Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: ACE-Inhibitor Effects on Total Hip and Knee Arthroplasty Patients
Status: TERMINATED
Conditions: Adverse Effects of Angiotensin-converting-enzyme Inhibitors|Hypotension
Interventions: DRUG: ACE-I Cessation group|DRUG: ACE-I Continuation group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preoperative Anti-PD-1 Antibody Combined With Chemoradiotherapy for Locally Advanced Squamous Cell Carcinoma of Esophagus
Status: COMPLETED
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Covid-19 Associated Pneumonia With Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells
Status: COMPLETED
Conditions: COVID|Covid-19|Coronavirus|Pneumonia|Pneumonia, Viral|Pneumonia, Interstitial|Sars-CoV2
Interventions: BIOLOGICAL: Allogenic pooled olfactory mucosa-derived mesenchymal stem cells|OTHER: Standard treatment according to the Clinical protocols
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S-Caine™ Peel (Skin Numbing Cream) to Treat Pain During Non-Ablative Facial Laser Resurfacing in Adults
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: S-Caine™ Peel (lidocaine and tetracaine topical cream 7%/7%)|DRUG: Placebo Peel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Intradermal Injection of rHuPH20 or Placebo in Participants With Nickel Allergic Contact Dermatitis
Status: COMPLETED
Conditions: Dermatitis, Allergic Contact
Interventions: DRUG: rHuPH20|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of CGF on Frequency of Alveolar Osteitis Following Partially Erupted Mandibular Third Molar Surgery
Status: COMPLETED
Conditions: Alveolar Osteitis|Impacted Tooth
Interventions: PROCEDURE: Concentrated Growth Factor (Test group)|PROCEDURE: Non-Concentrated Growth Factor (Control group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Belantamab Mafadotin Maintenance Therapy After Salvage Autologous Hematopoietic Cell Transplantation in Patients With Relapse Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Belantamab mafodotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Levodopa Benserazide Generic Formulation Versus the Originator
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Levodopa Benserazide Madopar|DRUG: Levodopa Benserazide Teva Italia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot of Methylphenidate in Mild Cognitive Impairment and Dementia Participants.
Status: COMPLETED
Conditions: Alzheimer Dementia
Interventions: DRUG: Methylphenidate Extended Release Oral Capsule|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ablative Fractional Laser for Sclerotic GVHD-Associated Joint Contractures
Status: TERMINATED
Conditions: Subjects With Severe, Refractory Sclerotic Skin Changes
Interventions: DEVICE: CO2 Laser|RADIATION: Ultrasound|DIAGNOSTIC_TEST: Skin Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cognitive Training and Brain Stimulation in Patients With Post-COVID-19 Cognitive Impairment
Status: RECRUITING
Conditions: COVID-19|Post-COVID-19
Interventions: DEVICE: Anodal tDCS|DEVICE: Sham tDCS|BEHAVIORAL: Intensive cognitive training|BEHAVIORAL: Progressive muscle relaxation (PMR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Breastmilk and Serum Exosomes in Neonatal Jaundice Due to ABO Incompatibility
Status: NOT_YET_RECRUITING
Conditions: Neonatal Jaundice From Other Specified Causes|ABO Incompatibility|ABO Hemolytic Disease
Interventions: OTHER: Exosome profile study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety and Tolerability Study of Arformoterol Tartrate Inhalation Solution in Pediatric Subjects
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: arformoterol|DRUG: levalbuterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Physical Therapy Wound Care Modalities in Patients With Spinal Cord Injury (SCI)
Status: RECRUITING
Conditions: Spinal Cord Injuries|Pressure Injuries
Interventions: PROCEDURE: pulsed wound irrigation (PWI)|PROCEDURE: electrical stimulation (ES)|PROCEDURE: electrical stimulation (ES) and pulsed wound irrigation (PWI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temocillin Use in Complicated Urinary Tract Infections Due to Extended Spectrum Beta-Lactamases (ESBL)/AmpC Enterobacteriaceae
Status: WITHDRAWN
Conditions: Urinary Tract Infection
Interventions: DRUG: Temocillin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Topical Benzocaine for Analgesia in Lingual Frenotomy of the Newborn
Status: TERMINATED
Conditions: Neonatal Tongue-tie|Maternal Nipple Pain Upon Breastfeeding|Neonatal Latch Difficulties
Interventions: DRUG: Topical Benzocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Red Yeast Rice and Subclinical Atherosclerosis in Patients With Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DIETARY_SUPPLEMENT: Tea|DIETARY_SUPPLEMENT: RYR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Reduced Intensity Stem Cell Transplantation (RIST) for Patients With Hematological Malignancies Conditioned With Fludarabine and Busulfan
Status: COMPLETED
Conditions: Hematologic Malignancies
Interventions: PROCEDURE: Reduced Intensity Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chidamide Bridging for CAR-T Therapy
Status: RECRUITING
Conditions: Non Hodgkin's Lymphoma
Interventions: DRUG: Chidamide|DRUG: Fludarabine and cyclophosphamide|BIOLOGICAL: Anti-CD19 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Doxorubicin, Vinblastine, Dacarbazine, Brentuximab Vedotin, and Nivolumab in Treating Patients With Stage I-II Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Ann Arbor Stage I Hodgkin Lymphoma|Ann Arbor Stage IA Hodgkin Lymphoma|Ann Arbor Stage IB Hodgkin Lymphoma|Ann Arbor Stage II Hodgkin Lymphoma|Ann Arbor Stage IIA Hodgkin Lymphoma|Ann Arbor Stage IIB Hodgkin Lymphoma|Classic Hodgkin Lymphoma
Interventions: DRUG: Brentuximab Vedotin|DRUG: Dacarbazine|DRUG: Doxorubicin|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab|DRUG: Vinblastine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1a/1b Study of PPI-383 in Healthy Adults and Hepatitis C Patients
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: PPI-383|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study of the Surpass Aneurysm-Embolization System in Intracranial Arteries
Status: WITHDRAWN
Conditions: Aneurysm
Interventions: DEVICE: Aneurysm-Embolization System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Quality Improvement System Study
Status: COMPLETED
Conditions: Adenoma Colon|Gastric Precancerous Condition
Interventions: BEHAVIORAL: Quality audit and feedback|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of the Efficacy of GGON: a Cognitive Training App for Orthorexia Nervosa.
Status: NOT_YET_RECRUITING
Conditions: Orthorexia Nervosa
Interventions: DEVICE: GGON mobile app.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess Safety and Tolerability of OPN-6602 in Subjects With Relapsed and/or Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Relapsed Multiple Myeloma|Refractory Multiple Myeloma
Interventions: DRUG: OPN-6602|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ferric Carboxymaltose in Gastrointestinal Stromal Tumor (GIST) Patients With Iron Deficiency Anemia (IDA) Receiving Systemic Therapy
Status: TERMINATED
Conditions: Malignant Neoplasms of Mesothelial and Soft Tissue|Gastrointestinal Stromal Tumor With Neurogenic Differentiation
Interventions: DRUG: Ferric Carboxymaltose|DIETARY_SUPPLEMENT: Iron Supplements|BEHAVIORAL: Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluating the Effectiveness of Treatment for Metacognition in Moderate and Severe Traumatic Brain Injury
Status: COMPLETED
Conditions: Brain Injuries, Traumatic
Interventions: BEHAVIORAL: Listening-based intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficiency of Mouth-to-nose Breathing With Mouth-to-mouth Breathing
Status: COMPLETED
Conditions: Cardiopulmonary Resuscitation|Respiratory Physiology
Interventions: OTHER: Mouth-to-mouth or mouth-to-nose breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study Investigating the Safety and Pharmacokinetics of Repeat-dose Intravenous Infusion of MTP-131 in Subjects With Impaired Renal Function
Status: COMPLETED
Conditions: Normal and Impaired Renal Function
Interventions: DRUG: MTP-131|DRUG: MTP-131|DRUG: MTP-131|DRUG: MTP-131
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Probiotic on Depression
Status: COMPLETED
Conditions: Depression
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OSI-774 (Tarceva) in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-small-cell Lung
Interventions: DRUG: Tarceva (erlotinib HCl, OSI-774 )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Early Versus Ultra Early Surgical Treatment of Ruptured Intracranial Aneurysms
Status: NOT_YET_RECRUITING
Conditions: Aneurysmal Subarachnoid Hemorrhage
Interventions: PROCEDURE: Ultra early (<24 hours) ruptured aneurysm clipping|PROCEDURE: Early (24-72 hours) ruptured aneurysm clipping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Dose Enteral Tranexamic Acid in Critically Ill Patients
Status: TERMINATED
Conditions: Shock|Sepsis|Hypotension|Critical Illness
Interventions: DRUG: Tranexamic Acid|DRUG: Control Intervention (Carrier fluid only)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of RECO-18 on Infertile Women Undergoing in Vitro Fertilization-embryo Transfer
Status: UNKNOWN
Conditions: Fertility Disorders|Infertility, Female
Interventions: DIETARY_SUPPLEMENT: RECO-18|DIETARY_SUPPLEMENT: Multi-vitamins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yi Jin Jing Tiger Roaring Speech Rehabilitation With Real-Time Feedback Technique for PD
Status: UNKNOWN
Conditions: Speech Disorders|Parkinson Disease
Interventions: BEHAVIORAL: Yi Jin Jing Tiger Roaring Speech Rehabilitation|BEHAVIORAL: Conventional Speech Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance Evaluation of the NeuMoDx™ FluA/FluB/RSV/Severe Acute Respiratory Syndrome-CoV-2 Assay
Status: RECRUITING
Conditions: Respiratory Disease
Interventions: DEVICE: NeuMoDx™ FluA/FluB/RSV/SARS-CoV-2 Assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Horse Riding Simulator With or Without Visual Feedback on Balance and Postural Control
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: HORSE RIDING SIMULATOR WITH VISUAL FEEDBACK|OTHER: HORSE RIDING SIMULATOR WITHOUT VISUAL FEEDBACK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Preoperative Corticosteroids in Autoimmune Thyroid Disease
Status: RECRUITING
Conditions: Graves Disease|Hashimoto Disease
Interventions: DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rescuing the Microbiome Effectively With Different Doses of B. Infantis in Infants
Status: COMPLETED
Conditions: Gut Microbiome
Interventions: OTHER: B. infantis EVC001|OTHER: Lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: EXploring Patterns of Use and Effects of Adult Day Programs to Improve Trajectories of Continuing carE
Status: NOT_YET_RECRUITING
Conditions: Adult Day Programs|Continuing Care|Old Age; Dementia|Family/Friend Caregivers
Interventions: OTHER: Adult day program use|OTHER: Other community care (non-attendees)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial to Evaluate Efficacy of 3 Types of Treatment in Patients With Pneumonia by COVID-19
Status: UNKNOWN
Conditions: COVID-19 Pneumonia
Interventions: DRUG: Imatinib tablets|DRUG: Baricitinib Oral Tablet|OTHER: Supportive tratment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-monitoring and Reflection's Impact on Psychotherapy Outcomes: A Trial Protocol.
Status: NOT_YET_RECRUITING
Conditions: Psychotherapy|Therapeutic Alliance|Psychological
Interventions: OTHER: Self-Monitoring|OTHER: Individual Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neutrophil Extracellular Traps as a Biomarker to Predict Portal Vein Tumor Thrombosis in Patients With Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Neutrophil Extracellular Trap Formation|Portal Vein Tumor Thrombosis
Interventions: OTHER: test NETs markers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Theobromine and Caffeine on Mood, Cognition and Blood Pressure
Status: COMPLETED
Conditions: Mood
Interventions: DIETARY_SUPPLEMENT: theobromine|DIETARY_SUPPLEMENT: Caffeine|DIETARY_SUPPLEMENT: caffeine + theobromine|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Activity of TAK-931 in Participants With Metastatic Pancreatic Cancer, Metastatic Colorectal Cancer, and Other Advanced Solid Tumors
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer|Colorectal Cancer|Esophageal Neoplasms|Carcinoma, Non-small-cell Lung
Interventions: DRUG: TAK-931
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label, Randomized Trial to Determine the Effect of Icodextrin Versus Dextrose (Dianeal 2.5%) in HOMA IR
Status: WITHDRAWN
Conditions: End Stage Renal Disease|Continuous Ambulatory Peritoneal Dialysis
Interventions: PROCEDURE: Blood samples|PROCEDURE: Measure of peritoneal ultrafiltrates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Detection and Miss Rates of Blue Laser Imaging Versus Conventional White Light Colonoscopy
Status: UNKNOWN
Conditions: Colorectal Adenoma
Interventions: DEVICE: blue laser imaging colonoscopy|DEVICE: conventional white light colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Post-operative Pain Relief for Paediatric Inguinal-Scrotal Surgery
Status: UNKNOWN
Conditions: Hernia, Inguinal
Interventions: PROCEDURE: Caudal block|PROCEDURE: Nerve Block|DRUG: Standarising intraoperative pain relief
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Berberine Ursodeoxycholate (HTD1801) in Patients With Type 2 Diabetes Inadequately Controlled With Metformin
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: HTD1801|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Citrus Extract on Oxidative Stress
Status: COMPLETED
Conditions: Elderly
Interventions: DIETARY_SUPPLEMENT: Citrus extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adjuvant Immunotherapy After Salvage Surgery in Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crizotinib Combined With Etoposide Capsule Followed by Auto-HSCT for Relapsed and Refractory ALK+ ALCL
Status: UNKNOWN
Conditions: ALK-Positive Anaplastic Large Cell Lymphoma
Interventions: DRUG: Crizotinib|DRUG: Etoposide Capsule|PROCEDURE: Auto-HSCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fibro-inflammatory Progression From Acute to Chronic Pancreatitis
Status: RECRUITING
Conditions: Pancreatitis|Acute Pancreatitis|Recurrent Pancreatitis|Chronic Pancreatitis|Inflammation|Fibrosis
Interventions: DIAGNOSTIC_TEST: Diagnostic imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Love, Sex & Choices: A Web Series on Mobile Devices to Reduce Black Women's HIV Risk
Status: COMPLETED
Conditions: HIV|Sexual Behavior|Women's Role|Risk Behavior|Chlamydia
Interventions: BEHAVIORAL: Love, Sex, & Choices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study to Compare the Pharmacokinetics and Pharmacodynamics of ASA Powder for Oral Inhalation With Non-enteric-coated Chewable Aspirin in Adult Subjects With Obstructive or Restrictive Pulmonary Function
Status: TERMINATED
Conditions: Obstructive Pulmonary Function|Restrictive Pulmonary Function
Interventions: DRUG: single dose (100 mg) of ASA|DRUG: single dose (162 mg) of non-enteric-coated chewable aspirin tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-CD20 Antibodies for Treatment of SLE-PAH
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus|Pulmonary Arterial Hypertension
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Cryotherapy on Ankle Movements and Gait of Spastic Hemiparetic Subjects
Status: UNKNOWN
Conditions: Stroke|Muscle Spasticity
Interventions: OTHER: Cryotherapy|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Motivational Interviewing Integrated With Social Network Counseling for Teens
Status: COMPLETED
Conditions: Substance Use
Interventions: BEHAVIORAL: Motivational Interviewing w/Social Network Counseling|BEHAVIORAL: Active Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Outcomes Mandate National Integration With Cannabis as Medicine
Status: RECRUITING
Conditions: Chronic Pain|Chronic Pain Syndrome|Chronic Pain Due to Injury|Chronic Pain Due to Trauma|Fibromyalgia|Seizures|Hepatitis C|Cancer|Crohn Disease|HIV/AIDS|Multiple Sclerosis|Traumatic Brain Injury|Sickle Cell Disease|Post Traumatic Stress Disorder|Tourette Syndrome|Ulcerative Colitis|Glaucoma|Epilepsy|Inflammatory Bowel Diseases|Parkinson Disease|Amyotrophic Lateral Sclerosis|Chronic Traumatic Encephalopathy|Anxiety|Depression|Insomnia|Autism|Opioid-use Disorder|Bipolar Disorder|Covid19|SARS-CoV Infection|COVID-19|Corona Virus Infection|Coronavirus
Interventions: DRUG: Cannabis, Medical|DEVICE: RYAH-Medtech Inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of a Novel Oropharyngeal Airway: The ManMaxAirway
Status: UNKNOWN
Conditions: Airway Obstruction|Respiratory Complication
Interventions: DEVICE: ManMaxAirway oropharyngeal airway adjunct|DEVICE: Guedel Oropharyngeal airway adjunct|DEVICE: No airway adjunct
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Efficacy of Perioperative Nivolumab With or Without Relatlimab for Patients With Potentially Resectable Hepatocellular Carcinoma (HCC)
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Nivolumab|DRUG: Relatlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aflibercept anD navigateD vErsus coNvensional Laser in Diabetic macUlar edeMa
Status: COMPLETED
Conditions: Diabetic Macular Oedema
Interventions: DEVICE: Navigated laser|DEVICE: Conventional laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fibroblast Specific Inhibition of LOXL2 and TGFbeta1 Signaling in Patients With Pulmonary Fibrosis.
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Epigallocatechin-3-gallate (EGCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Assess Effects of Postbiotic vs Placebo in Participants With Diarrhea-predominant IBS
Status: NOT_YET_RECRUITING
Conditions: Diarrhea-Predominant Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Postbiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone
Status: COMPLETED
Conditions: Post Operative Pain|Hyperalgesia
Interventions: DRUG: ketamine infusion|DRUG: Methadone PCA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of AZD2171 in Patients With Non-Small Cell Lung Cancer or Head & Neck Cancer
Status: COMPLETED
Conditions: Carcinoma|Non-Small-Cell Lung Carcinoma|Head and Neck Neoplasms
Interventions: DRUG: AZD2171
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VIGABatrin in Post-anoxic STATus Epilepticus - Phase IIa
Status: COMPLETED
Conditions: Status Epilepticus, Electrographic|Coma
Interventions: DRUG: Vigabatrin Only Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liraglutide Improve Cognitive Function in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Liraglutide|DRUG: Oral antidiabetic drugs: Metformin, Sulfonylureas (2nd generation), Thiazolidinediones, α-Glucosidase inhibitors, and Glinides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Modified Cellulose on Colonic Fermentation of Inulin
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Psyllium|DIETARY_SUPPLEMENT: Methylcellulose|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Roflumilast on Exacerbations in Patients With Non-cystic Fibrosis Bronchiectasis
Status: COMPLETED
Conditions: Exacerbation Copd|Bronchiectasis|Lung Function Decreased
Interventions: DRUG: Roflumilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Norspan® Patches Versus Tramadol in Subjects With Chronic, Moderate to Severe Osteoarthritis Pain in the Hip Knee and/or Lumbar Spine
Status: COMPLETED
Conditions: Osteoarthritis|Pain
Interventions: DRUG: Buprenorphine|DRUG: Tramadol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Hemorrhage With Prophylactic Oxytocin for Dilation and Evacuation
Status: NOT_YET_RECRUITING
Conditions: Hemorrhage
Interventions: DRUG: Oxytocin + normal saline|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Computer-Based Auditory Rehabilitation
Status: COMPLETED
Conditions: Presbycusis
Interventions: BEHAVIORAL: Video game based training 1|BEHAVIORAL: Video game based training 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Ranging, Switch Study of Islatravir (ISL) and Ulonivirine (MK-8507) Once-Weekly in Virologically-Suppressed Adults With Human Immunodeficiency Virus Type 1 (HIV-1) [MK-8591-013]
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV-1 Infection
Interventions: DRUG: Islatravir|DRUG: Ulonivirine|DRUG: BIC/FTC/TAF|DRUG: Placebo to ISL|DRUG: Placebo to Ulonivirine|DRUG: Placebo to BIC/FTC/TAF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PD1 Antibody Combined With mFOLFOX6 Neoadjuvant Therapy for Advanced Resectable Metastatic Colon Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastatic Colon Cancer
Interventions: DRUG: Serplulimab, mFOLFOX6
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors
Status: UNKNOWN
Conditions: Brain and Central Nervous System Tumors|Metastatic Cancer
Interventions: DRUG: verteporfin|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Concordance of Imaging and Pathology Diagnosis of Extranodal Tumour Deposits
Status: RECRUITING
Conditions: Adenocarcinoma of the Rectum
Interventions: DIAGNOSTIC_TEST: MRI mapping to guide pathological sampling of extranodal tumour deposits
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: beclomethasone dipropionate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Evaluating the Association of Hypofractionated Stereotactic Radiation Therapy and Durvalumab for Patients With Recurrent Glioblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma
Interventions: RADIATION: Hypofractionated stereotactic radiation therapy|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adding L-carnitine in Clomiphene Resistant Polycystic Ovary Improves the Quality of Ovulation and the Pregnancy Outcome
Status: UNKNOWN
Conditions: Treatment Resistant Disorders
Interventions: DRUG: l-carnitine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Procalcitonin Level to Discontinue Antibiotics on ICU Patients With no Obvious Site of Infection
Status: TERMINATED
Conditions: Infection|Bacterial Infection|Sepsis
Interventions: DEVICE: Procalcitonin assay - B.R.A.H.M.S PCT sensitive Kryptor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise Intervention for Pts With Metastatic Castration-Resistant Prostate Cancer Receiving Abiraterone or Enzalutamide
Status: WITHDRAWN
Conditions: Metastatic Castration Resistant Prostate Cancer (mCRPC)
Interventions: BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Single Dose Study to Assess the Safety, Effects, and Blood and Urine Drug Levels of AZD3293 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Young Volunteers|Healthy Elderly Volunteers
Interventions: DRUG: AZD3293|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE