pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Trial of Metformin in Individuals With Fragile X Syndrome
Status: COMPLETED
Conditions: Fragile X Syndrome|Fragile X Mental Retardation Syndrome|Mental Retardation, X Linked|Genetic Diseases, X-Linked|Trinucleotide Repeat Expansion|Fra(X) Syndrome|Intellectual Disability|FXS|Neurobehavioral Manifestations|Sex Chromosome Disorders
Interventions: DRUG: Placebo Medication|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: More Options for Children and Adolescents (MOCHA): Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in HIV-Infected Children and Adolescents
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections
Interventions: DRUG: Oral Cabotegravir (CAB)|DRUG: Oral Rilpivirine (RPV)|DRUG: Long-Acting Injectable Cabotegravir (CAB LA)|DRUG: Long-Acting Injectable Rilpivirine (RPV LA)|DRUG: Combination Antiretroviral Therapy (cART)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Reduction of Antenatal Betamethasone Given to Prevent the Neonatal Complications Associated With Very Preterm Birth
Status: COMPLETED
Conditions: Neonatal Complications
Interventions: DRUG: betamethasone 24 mg|DRUG: 12mg betamethasone +placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Acceptability and Impact of Diarrheal Etiology Prediction (DEP) Algorithm
Status: COMPLETED
Conditions: Diarrhea Infectious|Algorithms|Decision Support Systems, Clinical|Clinical Decision-Making
Interventions: DIAGNOSTIC_TEST: Rehydration calculator application with DEP algorithm|DIAGNOSTIC_TEST: Rehydration calculator application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of a Fourth Hexavalent Vaccine After Hematopoietic Stem Cell Transplantation
Status: UNKNOWN
Conditions: Haemopoietic Stem Cell Transplantation|Allograft
Interventions: DRUG: 4th dose of hexavalent vaccine 1 month after the 3rd dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Pilot Study of the Effect of High Protein Supplement and Exercise Therapy on Preservation of Skeletal Muscle Mass and Quality of Life in Patients With Gastric Cancer and Pancreatic Cancer Treated With Chemotherapy
Status: COMPLETED
Conditions: Gastric Cancer|Pancreatic Cancer
Interventions: OTHER: Exercise Therapy, High Protein supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Feasibility of Using Neuroscience Education in Adults Over 65 Years Old With Chronic Low Back and/or Lower Extremity Pain
Status: COMPLETED
Conditions: Back Pain|Lower Extremity Pain
Interventions: OTHER: Neuroscience Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study of Fostamatinib as Second Line Therapy in Adult Patients With Immune Thrombocytopenia (ITP) and Insufficient Response to a Prior Therapy
Status: TERMINATED
Conditions: ITP|Immune Thrombocytopenia
Interventions: DRUG: Fostamatinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PC-Based Cognitive Rehabilitation for Traumatic Brain Injury (TBI)
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: Digit span testing|BEHAVIORAL: Spatial span testing|BEHAVIORAL: Finger tapping|BEHAVIORAL: Simple reaction time|BEHAVIORAL: Choice reaction time|BEHAVIORAL: Verbal fluency|BEHAVIORAL: Verbal list learning|BEHAVIORAL: Trail making test|BEHAVIORAL: Design fluency|BEHAVIORAL: Questionnaire completion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Biomarkers in Patients Undergoing Chemotherapy for Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: capecitabine|DRUG: fluorouracil|DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium|DRUG: oxaliplatin|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effects of Blueberries on Symptoms and Underlying Mechanisms of Functional Gastrointestinal Disorders
Status: UNKNOWN
Conditions: Functional Gastrointestinal Disorders
Interventions: DIETARY_SUPPLEMENT: Blueberry|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnosis of Urethral Stricture With Sono-urethrography vs Conventional Urethrography (SONO-URETHRA)
Status: WITHDRAWN
Conditions: Urethral Stricture Disease
Interventions: RADIATION: Urografin 30%|RADIATION: NaCl 0,9 % in aqua
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Functional Consequences of the CTNS-deletion for the TRPV1-receptor in Cystinosis Patients
Status: COMPLETED
Conditions: Cystinosis
Interventions: OTHER: Challenge agent: capsaicin|OTHER: Challenge agent: placebo|DEVICE: Mechanical stimulation with Von Frey filaments|DEVICE: Temperature sensitivity measurement with Advanced Thermal Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Effectiveness of Trastuzumab Deruxtecan in Chinese Breast Cancer Patients (REFRESH)
Status: RECRUITING
Conditions: HER2-positive Breast Cancer|HER2-low Breast Cancer|Breast Cancer|Advanced Cancer
Interventions: DRUG: Trastuzumab deruxtecan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Music Practice and Marmet Technique on Lactation and Maternal Anxiety in Mothers With Premature Babies
Status: NOT_YET_RECRUITING
Conditions: Lactation
Interventions: OTHER: Music Group|OTHER: Marmet Technique Group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TINN2: Treat Infection in NeoNates 2
Status: WITHDRAWN
Conditions: Bronchopulmonary Dysplasia
Interventions: DRUG: Azithromycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: With Love, Grandma ("Con Cariño, Abuelita") Pilot Study
Status: RECRUITING
Conditions: Cancer, Breast|Cancer, Uterus|Cancer, Ovary|Obesity|Activity, Motor|Diet, Healthy
Interventions: BEHAVIORAL: With Love, Grandma ("Con Cariño, Abuelita")
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Taurine Supplementation Associated or Not With Exercise: Effect on Browning of White Adipose Tissue in Elderly Women With Sarcopenic Obesity
Status: ACTIVE_NOT_RECRUITING
Conditions: Browning of Subcutaneous White Adipose Tissue Post Intervention|Metabolic and Inflammatory Variables Post Intervention
Interventions: DIETARY_SUPPLEMENT: Taurine supplementation|OTHER: Pshysical exercise|OTHER: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of the Type of Stabilization in the Two-stage Knee Reimplantation on Reinfection - Prospective, Randomized Study.
Status: RECRUITING
Conditions: Knee Infection
Interventions: DEVICE: stabilization with stem|DEVICE: stabilization with sleeve
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of TAK-279 in Participants With Moderate-to-Severe Plaque Psoriasis
Status: NOT_YET_RECRUITING
Conditions: Plaque Psoriasis
Interventions: DRUG: TAK-279
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In Vivo Assessment of Geno- and Cytotoxicity of Fluoridated Toothpastes and Mouthrinses on Buccal Epithelial Cells
Status: UNKNOWN
Conditions: DNA Damage
Interventions: OTHER: Flouride in mouthrinses|OTHER: Placebo mouthrinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: HIP-STITCH (Wound Recovery After THA)
Status: NOT_YET_RECRUITING
Conditions: Wound Healing Disturbance of
Interventions: DEVICE: Ethicon Monocryl Smooth Suture|DEVICE: Ethicon Vicryl Rapide Braided Suture|DEVICE: Flexifuze Indermil Topical Skin Adhesive|DEVICE: Dermabond Prineo Skin Closure System|DEVICE: Stryker Zip Skin Closure System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine in Metastatic Estrogen Receptor-Positive Breast Cancer Progressing on Hormonal Therapy
Status: TERMINATED
Conditions: Estrogen Receptor Positive Breast Cancer
Interventions: DRUG: hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EARLY IFNb-1a and Atorvastatin Combination Therapy of Isolated Clinical Syndrome Suggestive of Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Rebif
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 5, 2013
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluzone® standard IIV3|BIOLOGICAL: Fluzone® standard IIV3 Pediatric Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Use of Chewing Gum for Xerostomia and Hyposalivation After Radiotherapy for Oral and Oropharyngeal Tumors
Status: COMPLETED
Conditions: Head and Neck Cancer|Radiation Therapy Complication|Xerostomia|Hyposalivation
Interventions: DIETARY_SUPPLEMENT: Chewing gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The CLOCK Study - A Human Dietary Intervention Study on Peripheral Circadian Clocks and Energy Metabolism
Status: COMPLETED
Conditions: Metabolic Response to Dietary Modification
Interventions: OTHER: Carbohydrate-rich (HC)|OTHER: Fat-rich (HF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Whole Heart Radiotherapy for End-stage Heart Failure
Status: NOT_YET_RECRUITING
Conditions: Heart Failure NYHA Class III|Heart Failure NYHA Class IV|End-stage Heart Failure|Heart Failure With Reduced Ejection Fraction
Interventions: OTHER: Whole Heart Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Optimal Renoprotective Dose of Aliskiren in Hypertensive Patients With Type 2 Diabetes and Incipient or Overt Nephropathy
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Aliskiren|DRUG: Aliskiren|DRUG: Aliskiren|DRUG: Aliskiren
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose Study on Safety, Tolerability, and Pharmacokinetics of AMG 581 in Healthy Subjects or Subjects With Schizophrenia or Schizoaffective
Status: COMPLETED
Conditions: Schizophrenia or Schizoaffective Disorder
Interventions: DRUG: AMG 581|DRUG: Placebo|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Direct Oral Anticoagulation (DOAC) Interruption and DOAC Continuation in Patients Undergoing Elective Invasive Coronary Angiography or Percutaneous Coronary Intervention
Status: UNKNOWN
Conditions: Atrial Fibrillation|Coronary Artery Disease|Anticoagulants
Interventions: OTHER: Uninterrupted NOAC use|OTHER: Interrupted NOAC use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CIMER: Combined Immunotherapies in Metastatic ER+ Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: RADIATION: Stereotactic Body Radiation Therapy (SBRT) (50GY in 5 fractions)|DRUG: Letrozole 2.5Mg Tab|DRUG: Palbociclib 125mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Biological Effect of Tarceva (OSI-774) for Patients Stricken by ENT Epidermoid Carcinoma
Status: COMPLETED
Conditions: Head and Neck Neoplasms
Interventions: DRUG: Tarceva
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Low-Carbohydrate Normocaloric Diet in Patients With Head and Neck Carcinoma (HNC)
Status: COMPLETED
Conditions: Head and Neck Carcinoma
Interventions: DIETARY_SUPPLEMENT: Dietary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: CBT-I or Zolpidem/Trazodone for Insomnia
Status: COMPLETED
Conditions: Chronic Insomnia
Interventions: DRUG: Zolpidem|BEHAVIORAL: Internet Cognitive Behavioral Therapy for Insomnia (CBT-I)|DRUG: Trazodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultherapy® for Treating the Face and Neck Using Standard Versus Simulines Transducers
Status: COMPLETED
Conditions: Skin Laxity
Interventions: DEVICE: Ulthera Treatment at EL2|DEVICE: Ulthera Treatment at EL4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tapering of Biologics in Inflammatory Arthritis Patients in Remission
Status: ACTIVE_NOT_RECRUITING
Conditions: Rheumatoid Arthritis|Psoriatic Arthritis
Interventions: DIAGNOSTIC_TEST: Drug level testing with feedback provided|DIAGNOSTIC_TEST: Drug level testing with no feedback provided
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Breastfeeding Counseling Based on Motivational Interviewing
Status: ACTIVE_NOT_RECRUITING
Conditions: Breastfeeding Counseling Based on Motivational Interviewing
Interventions: BEHAVIORAL: Breastfeeding Counseling Based on Motivational Interviewing|BEHAVIORAL: Standard Breastfeeding Consultancy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Participants Satisfaction, Quality of Life and Effectiveness of Flexible-Dose of Paliperidone Extended Release (ER) in Participants With Schizophrenia, Previously Treated With Risperidone
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Paliperidone Extended Release (ER)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Unipolar or Bipolar Hemiarthroplasty in the Treatment of Displaced Femoral Neck Fractures.
Status: COMPLETED
Conditions: Hip Fractures
Interventions: DEVICE: Unipolar hip hemiarthroplasty|DEVICE: Bipolar hip hemiarthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Intervention to Assess the Impact of Practical Strategies for Healthy Eating
Status: COMPLETED
Conditions: Overweight and Obesity|Healthy Diet
Interventions: DEVICE: Standard serving utensil toolkit|DEVICE: Optimsed portion-control toolkit
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Single-Blind Placebo Run-In Study of Venlafaxine for Activity-Limiting Osteoarthritis Pain
Status: COMPLETED
Conditions: Osteoarthritis|Pain
Interventions: DRUG: Venlafaxine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Aflibercept Injection for Polypoidal Choroidal Vasculopathy With Hemorrhage or Exudation
Status: COMPLETED
Conditions: Polypoidal Choroidal Vasculopathy
Interventions: DRUG: Intravitreal aflibercept injection 2.0mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real World Evidence in China: Faricimab Use in Diabetic Macular Edema, Retinal Vein Occlusion, and Neovascular Age-Related Macular Degeneration (The Farseeing Study)
Status: RECRUITING
Conditions: Diabetic Macular Edema|Neovascular Age-related Macular Degeneration|Retinal Vein Occlusion
Interventions: DRUG: Faricimab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Home-Based Cardiac Rehabilitation for Patients With Heart Failure
Status: RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction|Heart Failure With Reduced Ejection Fraction|Cardiovascular Diseases
Interventions: OTHER: HBCR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Magnetic Resonance Imaging (MRI) in Young Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Cancer|Magnetic Resonance Imaging|Preoperative MRI
Interventions: PROCEDURE: Pre-operative bilateral breast MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Once-daily Oral Seviteronel in Patients With Castration-Resistant Prostate Cancer Progressing on Enzalutamide or Abiraterone.
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Seviteronel: given orally once daily in 28-day cycles
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Tolerability, and Safety Study of DFN-15
Status: COMPLETED
Conditions: Migraine Headache
Interventions: DRUG: DFN-15 Active|OTHER: DFN-15 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Coronal Extent of Obturation on Endo-perio Lesions
Status: COMPLETED
Conditions: Apical Periodontitis
Interventions: PROCEDURE: Root canal treatment and coronal restoration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Therapy to Reduce Cardiac Damage Among Vulnerable Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension|Left Ventricular Hypertrophy
Interventions: DIETARY_SUPPLEMENT: cholecalciferol (Vitamin D)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia
Status: RECRUITING
Conditions: Leukemia, Acute Lymphoblastic
Interventions: DRUG: Omitted Doxorubicin|DRUG: Omitted Vincristine+Dexamethasone pulses|DRUG: Inotuzumab Ozogamicin+Standard Maintenance Therapy|DRUG: Imatinib|DRUG: 6-tioguanine+Standard Maintenance Therapy|DRUG: Blinatumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of the Round-tunnel and Flat-tunnel Technique of ACL Reconstruction
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Rupture
Interventions: PROCEDURE: round tunnel technique|PROCEDURE: flat tunnel technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tourniquets Type Combat Application Tourniquet: Proximal or Distal Location, Simple or Staggered on Upper and Lower Limb
Status: COMPLETED
Conditions: Hemorrhage
Interventions: DEVICE: Proximal single upper limb|DEVICE: Proximal staggered upper limb|DEVICE: Distal single upper limb|DEVICE: Distal staggered upper limb|DEVICE: Proximal single lower limb|DEVICE: Proximal staggered lower limb|DEVICE: Distal single lower limb|DEVICE: Distal staggered lower limb
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Load Limits After Orthopaedic Surgery: Biofeedback vs. Conventional Method (AppPWB)
Status: NOT_YET_RECRUITING
Conditions: Surgery
Interventions: OTHER: Standard one-off instruction using a scale|DEVICE: Plantar pressure insoles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Tenofovir and Emtricitabine Following Overencapsulation
Status: COMPLETED
Conditions: Healthy Volunteers|Pharmacokinetics
Interventions: DRUG: TENOFOVIR DISOPROXIL FUMARATE 300 Mg / EMTRICITABINE 200 Mg ORAL TABLET [TRUVADA]|DEVICE: Proteus Sensor System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Transarterial Chemoembolization Using Doxorubicin Beads With or Without Sorafenib Tosylate in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery
Status: UNKNOWN
Conditions: Liver Cancer
Interventions: DRUG: doxorubicin-eluting beads|DRUG: sorafenib tosylate|OTHER: laboratory biomarker analysis|OTHER: pharmacogenomic studies|OTHER: pharmacological study|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: TAK-329 Glucose Clamp Study
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: TAK-329|DRUG: TAK-329|DRUG: Insulin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Dexmedetomidine Versus Propofol in Conjunction With Regional Block for Shoulder Arthroscopy
Status: COMPLETED
Conditions: Hemodynamic|Sedation|Satisfaction, Personal
Interventions: PROCEDURE: Shoulder Arthroscopy|PROCEDURE: Regional Block|DRUG: Propofol|DRUG: Dexmedetomidine|DIAGNOSTIC_TEST: BIS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Surgery and Convergence Insufficiency Intermittent Exotropia
Status: COMPLETED
Conditions: Complications
Interventions: PROCEDURE: Post exercise Surgery|PROCEDURE: Orthoptics|PROCEDURE: Postop orthoptics|PROCEDURE: Post exercises surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Internet-delivered Treatments for Depression and Anxiety in Primary Care (SUMMA)
Status: TERMINATED
Conditions: Depressive Disorder|Anxiety Disorders|Depression
Interventions: BEHAVIORAL: Space from Depression|BEHAVIORAL: Space from Anxiety
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Costs and Safety of Early Conversion From Intravenous to Oral Antibiotic Treatment in Patients With Severe Community-Acquired Pneumonia
Status: COMPLETED
Conditions: Severe Communtity-Acquired Pneumonia
Interventions: PROCEDURE: Conversion to oral antibiotic treatment after 3 days of intravenous antibiotic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study for Safety and Efficacy Evaluation of Imatinib Mesylate in Children With Chronic Myeloid Leukemia (CML) Philadelphia Chromosome-positive (Ph+)
Status: UNKNOWN
Conditions: Chronic Myeloid Leukemia (CML) With Philadelphia Chromosome-positive (Ph+)
Interventions: DRUG: Imatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carotid Body Function in Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Hypoxia
Interventions: DIAGNOSTIC_TEST: Hyperinsulemic-Euglycemic Clamp & Hypoxic Ventilatory Response (HVR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Tumour Growth and Oncological Treatment in Patients With CRLM Using Zebra Fish Embryo Model
Status: RECRUITING
Conditions: Colorectal Cancer Metastatic|Tumour Metastasis|Chemotherapy Effect|Tumor Growth
Interventions: DRUG: Chemotherapy drug
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Overlap Syndrome and PSC: Evaluating Role of Gut Microflora and Its Identification With Antibiotics in Children"
Status: COMPLETED
Conditions: Primary Sclerosing Cholangitis|Autoimmune Hepatitis|Overlap Syndrome
Interventions: DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Dentoxol® Mouthrinse for Oral Mucositis
Status: COMPLETED
Conditions: Oral Mucositis
Interventions: DEVICE: Dentoxol|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Lumiracoxib in Patients With Osteoarthritis and With Controlled Hypertension
Status: COMPLETED
Conditions: Osteoarthritis|Controlled Hypertension
Interventions: DRUG: lumiracoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adults, Children, Older Infants and Infants
Status: COMPLETED
Conditions: Typhoid Fever
Interventions: BIOLOGICAL: Vi-CRM197 vaccine|BIOLOGICAL: Vi Polysaccharide (PS) vaccine|BIOLOGICAL: Pneumococcal conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Hot Flushes in Breast Cancer Patients With Acupuncture
Status: COMPLETED
Conditions: Breast Cancer|Postmenopause
Interventions: DEVICE: acupuncture|DEVICE: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of High Tone External Muscle Stimulation on Peripheral Arterial Disease
Status: UNKNOWN
Conditions: Diabetic Peripheral Neuropathy
Interventions: DEVICE: high tone external muscle stimulation- stationary bicycle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A comparatiVe Study on Efficacy and Safety of Lipegfilgrastim in Comparison to Pegfilgrastim in Elderly Patients With Aggressive B Cell Non-HOdgkin Lymphomas at hIgh Risk for R-CHOP-21-inDuced Neutropenia
Status: COMPLETED
Conditions: Aggressive B Cell Non-Hodgkin Lymphomas at High Risk for R-CHOP-21-induced Neutropenia
Interventions: DRUG: lipegfilgrastim|DRUG: pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Cy-Atg vs Flu-Atg for the Conditioning Therapy in Allo-HCT for Adult Aplastic Anemia
Status: UNKNOWN
Conditions: Aplastic Anemia
Interventions: DRUG: Cy-ATG|DRUG: Flu-ATG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MK-0954E Phase III Long-Term Study in Participants With Hypertension (MK-0954E-356)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: L50/H12.5/A5|DRUG: L50/H12.5|DRUG: Placebo to L50/H12.5/A5|DRUG: Placebo to L50/H12.5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Perfluorobutane in Lesion Detection, Targeting and Response Assessment for Ablation of HCC
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Microwave Ablation
Interventions: DRUG: Perfluorobutane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: RFp on Suprascapular N. Versus RFp on Suprascapular N. and Circumflex in the Treatment of Painful Shoulder
Status: UNKNOWN
Conditions: Pain Syndrome
Interventions: PROCEDURE: pulsed radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Multi Centre, Interventional, Non-comparator, Open Label Study to Demonstrate the Efficacy, Performance and Safety of ConvaFoam™ Silicone, ConvaFoam™ Border and ConvaFoam™ Non-Adhesive Dressings in the Management of Surgical and Traumatic Wounds
Status: COMPLETED
Conditions: Surgical Wound|Trauma-related Wound
Interventions: DEVICE: ConvaFoam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study to Assess Sociodemographic and Clinical Features of Patients Treated With Rivaroxaban in Routine Clinical Practice of Hematologists, Cardiologists and Internists of Spain
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transcatheter Intra-arterial Limb Infusion of Cisplatin for Extremity Osteosarcoma
Status: COMPLETED
Conditions: Event-free Survival|Overall Survival|Local-recurrence Free Survival|Pathological Response
Interventions: DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determine the Effects of Gene Differences and Voriconazole on Enzyme CYP2B6 Activity in the Liver in Healthy Volunteers
Status: COMPLETED
Conditions: Efavirenz, Metabolism and Pharmacokinetics Changes
Interventions: DRUG: Efavirenz|DRUG: voriconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Efficacy and Safety of Dual-plasmid Hepatitis B Virus DNA Vaccine in Chronic Hepatitis B Patients
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: BIOLOGICAL: HBV DNA vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Metabolism in Chronic Kidney Disease Patients
Status: UNKNOWN
Conditions: Vitamin D Metabolism is in Chronic Kidney Disease
Interventions: DRUG: 10,000 IU of cholecalciferol for a total of 8 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Spinal Stabilization Exercises on Epicardial Fat Tissue and Exercise Capacity in Hypertensives
Status: RECRUITING
Conditions: Hypertension
Interventions: OTHER: Spinal Stabilization Exercise|OTHER: physical activity counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of MBSR and CBT for the Treatment of Insomnia in Cancer
Status: COMPLETED
Conditions: Cancer|Insomnia
Interventions: BEHAVIORAL: Mindfulness-Based Stress Reduction|BEHAVIORAL: Cognitive Behavior Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety and Pharmacokinetic Interaction Between HODO-22251 and HODO-22252 in Healthy Adults
Status: RECRUITING
Conditions: Type 2 Diabetes|Dyslipidemias
Interventions: DRUG: Empagliflozin 25 MG|DRUG: Ezetimibe/Rosuvastatin 10/10mg|DRUG: Empagliflozin 25 MG with Ezetimibe/Rosuvastatin 10/10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Investigate the Safety, Tolerability, Immunogenicity, and Pharmacodynamics of VXX-401 Administered IM in Adult Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypercholesterolemia
Interventions: DRUG: VXX-401|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk-Adapted Allogeneic Stem Cell Transplantation For Mixed Donor Chimerism In Patients With Non-Malignant Diseases
Status: UNKNOWN
Conditions: Bone Marrow Failure|Osteopetrosis|Fanconi Anemia|Severe Combined Immunodeficiency
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Cyclophosphamide 40|DRUG: Cyclophosphamide 30
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of AEE788 in Patients With Recurrent/Relapse Glioblastoma Multiforme (GBM)
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: AEE788
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study of Fruquintinib in Combination With Paclitaxel in Second Line Gastric Cancer(FRUTIGA)
Status: UNKNOWN
Conditions: Advanced Gastric Cancer
Interventions: COMBINATION_PRODUCT: fruquintinib +paclitaxel|COMBINATION_PRODUCT: fruquintinib placebo + paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reduction by Pasireotide of the Effluent Volume in High-output Enterostomy in Patients Refractory to Usual Medical Treatment
Status: COMPLETED
Conditions: Enterostomy
Interventions: DRUG: Pasireotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Portable Transcranial Electrical Stimulation and Internet-Based Behavioral Therapy for Major Depression Study
Status: COMPLETED
Conditions: Major Depressive Disorder|Unipolar Depression
Interventions: DEVICE: Double Active: Active portable transcranial stimulation (ptES) and active internet-based behavioral therapy (iBT)|DEVICE: ptES-only: Active portable transcranial stimulation (ptES) and sham internet-based behavioral therapy (iBT)|DEVICE: Double-sham: Sham portable transcranial stimulation (ptES) and sham internet-based behavioral therapy (iBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Antibiotics MIC Value on the Efficacy of Treatment Regimens for Helicobacter Pylori Infection.
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Proton pump inhibitor,clarithromycin,amoxicillin or metronidazole
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of Quetiapine (Seroquel XR) on Sleep During Alcohol Abstinence
Status: COMPLETED
Conditions: Alcoholism|Sleep Initiation and Maintenance Disorders
Interventions: DRUG: Quetiapine XR|DRUG: Placebo.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Weaning From Noninvasive Ventilation
Status: COMPLETED
Conditions: Hypercapnic Respiratory Failure|Weaning Failure|Noninvasive Ventilation
Interventions: OTHER: Protocol for weaning of noninvasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Post-Market Clinical Performance and Safety Evaluation of GamCath HighFlow Dolphin Protect Catheter
Status: ACTIVE_NOT_RECRUITING
Conditions: AKI - Acute Kidney Injury|Acute Renal Failure|CKD|ESRD
Interventions: DEVICE: Vascular access catheter to support dialysis or CRRT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neoadjuvant PD-1 Blockade in Resectable Oral Squamous Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Oral Squamous Cell Carcinoma
Interventions: DRUG: Camrelizumab|DRUG: Camrelizumanb plus TPF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of the 2023-2024 Updated COVID-19 Vaccines Against COVID-19 Infection
Status: RECRUITING
Conditions: COVID-19|Vaccine-Preventable Diseases|SARS CoV 2 Infection|Upper Respiratory Tract Infection|Upper Respiratory Disease
Interventions: BIOLOGICAL: Novavax COVID-19 vaccine (2023-2024 formula XBB containing)|BIOLOGICAL: Pfizer COVID-19 mRNA vaccine (2023-2024 formula XBB containing)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Trial Comparing Acute Toxicity in Patients With Gynecological Cancer Treated With VMAT
Status: ACTIVE_NOT_RECRUITING
Conditions: Gynecologic Cancer
Interventions: RADIATION: Volumetric modulated arc therapy|RADIATION: conventional radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Web-based Self-management Support Intervention on Health Outcomes in Patients With Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Neoplasms
Interventions: OTHER: Web-based interactive self-management support program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Guided and Unguided Online Self-help Psychological Intervention
Status: UNKNOWN
Conditions: Online Self-help Transdiagnostic Psychological Intervention|Anxiety|Depression
Interventions: OTHER: Self-help CBT with email reminder and text message|OTHER: Feedback calls on participants' progress
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Lu AF82422 in Participants With Multiple System Atrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple System Atrophy
Interventions: DRUG: Lu AF82422|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neurostimulation and Electromyographs Assessment of th TetraGraph in Healthy (Volunteers
Status: COMPLETED
Conditions: Electromyography|Neuromuscular Monitoring
Interventions: DEVICE: Neuromuscular stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Physical Activity and Nutrition in Children (PANIC) Study
Status: UNKNOWN
Conditions: Overweight|Glucose Metabolism Disorders|Lipid Metabolism Disorders|Blood Pressure|Atherosclerosis
Interventions: BEHAVIORAL: lifestyle counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Aroma on Fatigue Scores Among Women With Hypothyroidism
Status: COMPLETED
Conditions: Fatigue|Hypothyroidism
Interventions: OTHER: Aromatherapy Blend|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy
Status: RECRUITING
Conditions: Painful Diabetic Neuropathy
Interventions: DRUG: ISA specific
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rhythmic Auditory Stimulation & Gait Training
Status: COMPLETED
Conditions: Multiple Sclerosis|Gait Disorders, Neurologic
Interventions: OTHER: Rhythmic auditory stimulation|OTHER: Gait Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Maintenance Therapy of Apatinib After Chemoradiotherapy in Metastatic Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Nasopharyngeal Neoplasms
Interventions: DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vibratory Stimuli, A Novel Rehabilitation Method for Preventing Post - Traumatic Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Whole body vibration|DEVICE: Local muscle vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Isolated Limb Perfusion With Melphalan in Treating Patients With Stage IIIB-IV Melanoma or Sarcoma
Status: WITHDRAWN
Conditions: Basal Cell Carcinoma of the Skin|Eccrine Carcinoma of the Skin|Recurrent Adult Soft Tissue Sarcoma|Recurrent Melanoma|Recurrent Skin Cancer|Squamous Cell Carcinoma of the Skin|Stage III Adult Soft Tissue Sarcoma|Stage IIIB Melanoma|Stage IIIC Melanoma|Stage IV Adult Soft Tissue Sarcoma|Stage IV Melanoma
Interventions: DRUG: isolated limb perfusion|DRUG: melphalan|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of ORMD-0801 in Subjects With Type 2 Diabetes Mellitus
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: Placebo|DRUG: ORMD-0801 QD|DRUG: ORMD-0801 BD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multidimensional Phenotype Classification in Grade 3 Bronchopulmonary Dysplasia
Status: RECRUITING
Conditions: Bronchopulmonary Dysplasia
Interventions: DIAGNOSTIC_TEST: Chest computed tomography (CT) with angiography|DIAGNOSTIC_TEST: Bronchoscopy with bronchoalveolar lavage|DIAGNOSTIC_TEST: Echocardiography|DIAGNOSTIC_TEST: 24 hour esophageal pH ("potential of hydrogen") - multichannel intraluminal impedance (MII) monitoring (reflux testing)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase I Study of Isolated Hepatic Perfusion With Escalating Dose Melphalan Followed by Postoperative Hepatic Arterial Floxuridine and Leucovorin for Metastatic Unresectable Colorectal Cancers of the Liver
Status: COMPLETED
Conditions: Colorectal Neoplasm|Liver Neoplasm|Neoplasm Metastasis
Interventions: DRUG: Melphalan|DRUG: Floxuridine|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Thoracic RadiothErapy With Atezolizumab in Small Cell lUng canceR Extensive Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Small Cell Lung Cancer Extensive Stage|Thoracic Radiotherapy
Interventions: DRUG: Atezolizumab|RADIATION: thoracic radiotherapy (TRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safe and Effective Use of the Prefilled Safety Syringe or the Auto-injector for the Subcutaneous Self-injection of Bimekizumab Solution by Subjects With Active Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Bimekizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Gabapentin for Chronic Pain After Thoracotomy (GABATHOMIE).
Status: COMPLETED
Conditions: Postoperative Pain|Chronic Pain
Interventions: DRUG: Gabapentin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT