pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety Study of Frexalimab (SAR441344) in Adults With Nonrelapsing Secondary Progressive Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: Frexalimab|DRUG: Placebo|DRUG: MRI contrast-enhancing agents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Breakfast With Different Macronutrient Composition on PYY, Ghrelin, GLP-1,Glucose Level, VAS for Hunger, VAS for Satiety and Ad Libitum Intake 4 Hours After Breakfast in Obese Women
Status: COMPLETED
Conditions: PYY|Ghrelin|Appetite|Gut Hormones|Obesity|Protein Consumption
Interventions: BEHAVIORAL: diet with different composition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Moxibustion in a Randomized Trial for Version of Breech Position From Week 32
Status: COMPLETED
Conditions: Presentation; Breech, With External Version Before Labor
Interventions: OTHER: Moxibustion in primiparae|OTHER: Moxibustion in multiparae
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-blind Study to Evaluate the Tolerability of 2 Different Titration Methods of Rivastigmine Patch in AD Patients (MMSE 10-20)
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Active Comparator|DRUG: ENA713
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MCAT Versus VISTA With Volume Stable Collagen Matrix in RT3 Gingival Recession
Status: NOT_YET_RECRUITING
Conditions: Gingival Recession
Interventions: PROCEDURE: Modified Coronally Advanced Tunnel (MCAT)Technique|PROCEDURE: Vestibular Incision Subperiosteal Tunnel Access (VISTA)Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer
Status: RECRUITING
Conditions: Triple Negative Breast Cancer|PD-L1 Positive
Interventions: DRUG: Sacituzumab Govitecan-hziy|DRUG: Pembrolizumab|DRUG: Paclitaxel|DRUG: nab-Paclitaxel|DRUG: Gemcitabine|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of Tetanus, Diphtheria and Acellular Pertussis (Tdap) Vaccine
Status: UNKNOWN
Conditions: Tetanus|Diphtheria|Whooping Cough
Interventions: BIOLOGICAL: Biological: GC3111 vaccine|BIOLOGICAL: Biological: Boostrix® vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Investigate the Effect of Missed Pills on Follicular Development in Two Application Regimens of SH T 00186 D
Status: COMPLETED
Conditions: Contraceptives, Oral
Interventions: DRUG: YAZ (DRSP 3 mg/EE 0.02 mg, BAY86-5300)|DRUG: Yasminelle (SH T 00186 D)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Insulin Detemir in Combination With Liraglutide and Metformin Compared to Liraglutide and Metformin in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: insulin detemir|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crossover Study of Propranolol vs Ivabradine in POTS
Status: RECRUITING
Conditions: Postural Tachycardia Syndrome
Interventions: DRUG: Ivabradine 4-week course|DRUG: Propranolol 4-week course|DRUG: Placebo 4-week course
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maintaining Suppression of Testosterone With Transdermal Estradiol Gel
Status: TERMINATED
Conditions: Cancer of the Prostate
Interventions: DRUG: BHR-200 (0.36% transdermal 17β-estradiol gel)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Advanced PRF Combined With Nano-crystalline Hydroxyapatite for Management of Grade II Furcation Defects
Status: UNKNOWN
Conditions: Periodontitis
Interventions: PROCEDURE: Advanced PRF (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement|PROCEDURE: Open flap debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Longitudinal Natural History Study of Patients With Peroxisome Biogenesis Disorders (PBD)
Status: RECRUITING
Conditions: Peroxisome Biogenesis Disorder|Zellweger Spectrum Disorder|RCDP - Rhizomelic Chondrodysplasia Punctata|D-Bifunctional Protein Deficiency|Alpha-Methylacyl-CoA Racemase Deficiency|Peroxisomal Acyl-CoA Oxidase Deficiency|Peroxisomal Acyl-CoA Oxidase 2 Deficiency|ATP Binding Cassette Subfamily D Member 3 Gene Mutation|ACBD5 (AcylCoA Binding Domain 5) Deficiency|Adult Refsum Disease|Sterol Carrier Protein 2 Deficiency
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot Study of Peribulbar Triamcinolone Acetonide for Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: PROCEDURE: Focal laser photocoagulation|DRUG: 40mg triamcinolone|DRUG: 20mg triamcinolone|DRUG: 40mg triamcinolone + laser|DRUG: 20mg triamcinolone + laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of GNC-038, a Tetra-specific Antibody, in Participants With R/R Diffuse Large B-cell Lymphoma (DLBCL)
Status: RECRUITING
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: GNC-038
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Cross-Functional, Population-Representative, Web-Based, Epidemiologic Study to Estimate the Prevalence and Burden of Nocturia Due to Nocturnal Polyuria in the US
Status: COMPLETED
Conditions: Nocturnal Polyuria
Interventions: DIAGNOSTIC_TEST: Baseline EpiNP survey|DIAGNOSTIC_TEST: Bladder diary|DIAGNOSTIC_TEST: Testing of EpiNP baseline survey, bladder diary and a qualitative interview|OTHER: No other intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Human Recombinant Interferon Gamma in the Treatment of Ventilator-acquired Pneumonia in ICU Patients
Status: RECRUITING
Conditions: Pneumonia, Ventilator-Associated
Interventions: DRUG: Interferon gamma|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PD-1 Inhibitor Combined With Decitabine Followed by ASCT as Second-line Therapy for Relapsed or Refractory Classic Hodgkin's Lymphoma
Status: RECRUITING
Conditions: Hodgkin Lymphoma, Adult|Relapse|Refractory Hodgkin Lymphoma
Interventions: DRUG: PD-1 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Human Superoxide Dismutase (rhSOD) and Vascular Reactivity
Status: COMPLETED
Conditions: Inflammation
Interventions: DRUG: LPS 2 ng/kg intravenous (IV) bolus|DRUG: rhSOD 82,000 IU (8.2 mg)/min intraarterially|DRUG: Norepinephrine 60, 120, 240 pmol/min intraarterially over 5 min/dose level (two times; pre-dose and +3.5 hrs)|DRUG: Acetylcholine 6.25, 12.5, 25 nmol/min intraarterially over 3 min/dose level (two times; pre-dose and +3.5 hrs)|DRUG: Glyceroltrinitrate (nitroglycerine) 4, 8, 16 nmol/min over 3 min/dose level (two times; pre-dose and +3.5 hrs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: Zambia One Love Aim 3 Trial
Status: COMPLETED
Conditions: HIV|Sexually Transmitted Diseases|Neglected Diseases|Non-communicable Diseases
Interventions: BEHAVIORAL: Strengthening Our Vows (SOV)|BEHAVIORAL: Good Health Package Plus (GHPP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Weekly Cisplatin/Irinotecan and Radiotherapy in Patients With Locally Advanced Esophageal Cancer: Phase II Trial
Status: COMPLETED
Conditions: Esophageal Neoplasms
Interventions: DRUG: irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atrial Fibrillation Ablation The Hybrid Approach Versus Traditional Management
Status: WITHDRAWN
Conditions: Ablation of Atrial Fibrillation
Interventions: PROCEDURE: Pulmonary vein isolation ablation procedure for atrial fibrillation|PROCEDURE: Hybrid procedure for ablation of atrial fibrillation|PROCEDURE: The Cox Maze Procedure for Ablation of Atrial Fibrillation|PROCEDURE: Hybrid Procedure for Left Atrium >5 cm but < 6.1 cm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Locomotor Function Following Transcutaneous Electrical Spinal Cord Stimulation in Individuals With Hemiplegic Stroke
Status: RECRUITING
Conditions: Stroke
Interventions: DEVICE: Noninvasive spinal stimulation with gait training|DEVICE: Noninvasive spinal stimulation|DEVICE: Conventional gait training|OTHER: Sham|OTHER: Exploratory Phase - Optimization of Gait Training and Spinal Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peri-Operative Immune Checkpoint Inhibition and Cryoablation in Women With Triple-negative Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Pembrolizumab|PROCEDURE: Core Biopsy/Cryoablation|PROCEDURE: Breast Surgery|DRUG: Ipilimumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gleevec Maintenance Therapy After Induction Irinotecan and Cisplatin in Patients With C-Kit Positive Extensive SCLC
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Gleevec
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Subcutaneous SemaglutidE in Acute Ischemic sTroke
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Semaglutide|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Of Ketorolac Tromethamine Versus Naproxen For Moderate to Severe Back Pain Treatment
Status: COMPLETED
Conditions: Back Pain
Interventions: DRUG: Ketorolac Tromethamine|DRUG: Naproxen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Cryotherapy on Joint Function and Pressure Pain Threshold in Patients With Subacromial Impingement Syndrome.
Status: COMPLETED
Conditions: Pain|Inflammation
Interventions: PROCEDURE: physical therapy|OTHER: ice pack
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Keratoconus Using Collagen Cross-Linking
Status: UNKNOWN
Conditions: Keratoconus
Interventions: DRUG: Riboflavin-5-phosphate|DRUG: Sham cross-linking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Relevance of Thoracic Echography for the Early Diagnosis of Interstitial Lung Disease in Systemic Scleroderma - Pilot Study
Status: COMPLETED
Conditions: Systemic Sclerosis
Interventions: OTHER: thoracic echography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Clinical Trial Evaluating the Safety and Efficacy of IDP-110 in Patients With Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: IDP-110|DRUG: Clindamycin|DRUG: Benzoyl peroxide|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Zometa for the Management of Tumor-induced Hypercalcemia and Malignant Bone Pain in the Community
Status: COMPLETED
Conditions: Cancer|Hypercalcemia|Pain
Interventions: DRUG: Zoledronic acid (Zometa)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study to Compare a Limited Versus Extended Pelvic Lymphadenectomy During Prostatectomy
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: PROCEDURE: Limited pelvic Lymphadenectomy|PROCEDURE: Extended pelvic Lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical and Pharmacological Efficacy of Knosp Grade 0-2 Prolactinoma
Status: NOT_YET_RECRUITING
Conditions: Pituitary Tumor
Interventions: PROCEDURE: Transnasal transsphenoidal pituitary lesion resection under neuroendoscopy|DRUG: Bromocriptin 2.5mg, 2-3 times a day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplementation With Nutrients Modulating IGF-1 and Cytokines in Elderly People at Risk of Undernutrition
Status: COMPLETED
Conditions: Undernutrition
Interventions: DIETARY_SUPPLEMENT: Pre-intervention|DIETARY_SUPPLEMENT: Liquid nutritional supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Burst Spinal Cord Stimulation for Neuropathic Pain.
Status: COMPLETED
Conditions: Peripheral Neuropathic Pain|Radiculopathy|Lower Back Pain
Interventions: DEVICE: Burst SCS (Abbott Proclaim IPG and single lead Abbott Octrode at level Th9/10)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tildrakizumab in Pediatric Subjects With Chronic Plaque Psoriasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Moderate-to-severe Chronic Plaque Psoriasis
Interventions: DRUG: Tildrakizumab|DRUG: Placebo|DRUG: Tildrakizumab|DRUG: Tildrakizumab|DRUG: Tildrakizumab|DRUG: Etanercept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Upper Limb Chronic Neuropathic Pain by Electrical Stimulation of the Brachial Plexus Nerve Roots
Status: RECRUITING
Conditions: Neuralgia
Interventions: DEVICE: electrical stimulation of the brachial plexus nerve roots|OTHER: sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intraoperative Fluid Restriction on Postoperative Outcomes in Video-assisted Thoracic Surgery (VATS)
Status: UNKNOWN
Conditions: Acute Lung Injury (ALI)|Acure Respiratory Distress Syndrome (ARDS)|Sepsis
Interventions: DRUG: liberal fluid administration|DRUG: restrictive fluid administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Focused Cardiac Ultrasound
Status: COMPLETED
Conditions: Ventricular Dysfunction|Pericardial Effusion|Valvular Disease|Septal Defect
Interventions: DEVICE: Philips EPIQ 7 ultrasound machine|DEVICE: Philips Lumify Broadband sector array transducer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study on the Effect of Kaletra + Nevirapine as Maintenance Bitherapy Compared to a Triple Therapy Including Kaletra + Analogues in HIV Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Lopinavir-rtv (Kaletra): 3 capsules (600 mg)/12 h|DRUG: Nevirapine (Viramune): 1 comp (200mg)/12h
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Soft Drink Straw as an Alternative Device of Creating Positive Expiratory Pressure (PEP) in Thoracic Surgery Patients
Status: COMPLETED
Conditions: Thoracic Surgery
Interventions: OTHER: Pressure measurement during exhalation through a device consisted of a drinking straw of an inner diameter of 5mm, a disposable mouthpiece and a manometer|OTHER: Pressure measurement during exhalation through an alternative PEP device/soft drink straw.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Alcohol Use and Relationships - III
Status: UNKNOWN
Conditions: Intimate Partner Violence|Substance Use
Interventions: BEHAVIORAL: Brief Alcohol Intervention plus Standard Batterer Intervention|BEHAVIORAL: General Health Improvement Intervention plus Standard Batterer Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interventions to Attenuate Cognitive Decline: Keys to Staying Sharp
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Age-related Cognitive Decline
Interventions: BEHAVIORAL: Music Training I
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Segmental Epidural Block for Feeding Jeujunostomy in Cancer Patients
Status: COMPLETED
Conditions: Anesthesia
Interventions: PROCEDURE: Epidural anesthesia|PROCEDURE: general anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rehydration Following Exercise-Induced Dehydration
Status: COMPLETED
Conditions: Dehydration Related to Exercise
Interventions: OTHER: Water with flavoring and non-nutritive sweetener.|OTHER: High-Na low-CHO beverage|OTHER: Low-Na high-CHO beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability and Immunogenicity Study of 2 Different Regimens of Tetravalent Ad26.Mos4.HIV Prime Followed by Boost With Tetravalent Ad26.Mos4.HIV Along With Either Clade C gp140 Plus Adjuvant OR With a Combination of Mosaic and Clade C gp140 Plus Adjuvant in Healthy HIV Uninfected Adults
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Ad26.Mos4.HIV|BIOLOGICAL: Clade C gp140 plus adjuvant|BIOLOGICAL: Clade C gp140/Mosaic gp140 plus adjuvant|OTHER: Placebo|BIOLOGICAL: gp140 HIV Bivalent Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Osimertinib in First and Second Line Treatment of NSCLC Harboring EGFR Mutations From Circulating Tumor DNA
Status: COMPLETED
Conditions: Lung Neoplasms|EGFR Gene Mutations
Interventions: DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Usefulness of the CADISS® System for the Cleavage of Severe Adhesions in Cholecystectomy
Status: COMPLETED
Conditions: Cholecystitis, Acute
Interventions: COMBINATION_PRODUCT: CADISS® System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Marginal Bone Changes in Fixed All-on-Four Mandibular Prosthesis Using OT Bridge Attachment System
Status: NOT_YET_RECRUITING
Conditions: Edentulous Jaw
Interventions: PROCEDURE: patients reciveing all on 4 fixed mandibular prosthesis usimg conventionally screw retained multiunit abutments|PROCEDURE: all on 4 fixed mandibular prosthesis using OTbridge attachment system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Video Intervention to Decrease Patient Fear of Colonoscopy After a Positive Fecal Immunochemical Test
Status: COMPLETED
Conditions: Colorectal Carcinoma
Interventions: OTHER: Media Intervention|OTHER: Best Practice|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Goserelin, Flutamine, and Radiation Therapy in Treating Patients With Locally Advanced Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: flutamide|DRUG: goserelin acetate|RADIATION: low-LET cobalt-60 gamma ray therapy|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: the Effectiveness of Probiotics on Atopic Dermatitis With Cow Milk Allergy
Status: WITHDRAWN
Conditions: Atopic Dermatitis
Interventions: DRUG: ATP mixed probiotics|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First-Line EGFR-1 Tyrosine Kinase Inhibition in Patients With NSCLC With Mutant EGFR Gene
Status: UNKNOWN
Conditions: Lung Neoplasms|Non-Small Cell Lung Cancer|Adenocarcinoma, Bronchiolo-Alveolar
Interventions: DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibuprofen Plus Acetaminophen Versus Oxycodone Alone After Hand Surgery
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome|Dupuytren Contracture|Trigger Digit|Ganglion Cysts|De Quervain Disease
Interventions: DRUG: Oxycodone Hcl 5Mg|DRUG: Ibuprofen 400 mg|DRUG: Acetaminophen 650 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Galcanezumab (LY2951742) in Adult Participants With Episodic Migraine
Status: COMPLETED
Conditions: Migraine|Episodic Migraine
Interventions: DRUG: Galcanezumab|DRUG: Rimegepant|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of Obicetrapib in Combination With Ezetimibe as an Adjunct to HIS Therapy
Status: COMPLETED
Conditions: Dyslipidemias|High Cholesterol|Hypercholesterolemia
Interventions: DRUG: Obicetrapib|DRUG: Ezetimibe 10mg|OTHER: Obicetrapib placebo|OTHER: Ezetimibe placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: G-PUR® for Symptomatic Treatment in Irritable Bowel Syndrome With Diarrhea
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome With Diarrhea (IBS-D)
Interventions: DEVICE: 2.0g G-PUR®, oral administration|DEVICE: Placebo, oral administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Epigenorm Antivir Combined With Acupuncture for the Treatment of Osteoarthritis Patients Who Are Overweight or Obese
Status: UNKNOWN
Conditions: Osteoarthritis|Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: Epigenorm Antivir|PROCEDURE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison for the Patient With Alzheimer Disease the Impact of Three Different Groups of Patient Care
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: BEHAVIORAL: respite platform|BEHAVIORAL: Day care|BEHAVIORAL: No access to a respite structure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Supplementation of Vitamin D Deficiency in Older People With Acute Hip Fracture:
Status: COMPLETED
Conditions: Hip Fracture|Vitamin D Deficiency
Interventions: DRUG: Calcifediol (Vitamin D)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Mineral Density Changes in HIV-positive Females With Osteopenia Switching to Raltegravir
Status: TERMINATED
Conditions: HIV Infection|Osteopenia
Interventions: DRUG: raltegravir and atazanavir and ritonavir|DRUG: tenofovir/emtricitabine and atazanavir and ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of 2000 IU Per Day of Vitamin D for the Primary Prevention of Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DIETARY_SUPPLEMENT: vitamin D3|DIETARY_SUPPLEMENT: vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Elesclomol Sodium in Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Elesclomol Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Exercise as Adjunctive Therapy for Affective Disorder and Anxiety
Status: ACTIVE_NOT_RECRUITING
Conditions: Depression|Physical Inactivity|Bipolar Disorder|Anxiety Disorders|Anxiety|Posttraumatic Stress Disorder|ADHD|Autism|Social Phobia|Panic Disorder|Generalized Anxiety Disorder|Personality Disorders|Insomnia|Stress
Interventions: OTHER: Braining
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Look at How a Single Oral Dose of Carbon-14-Labelled [14C] BIIB091 Moves Through and is Processed by the Body in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: [14C]-BIIB091
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Screening for ALOA-IgG AtheroAbzyme Test
Status: COMPLETED
Conditions: Myocardial Ischemia|Acute Coronary Syndrome
Interventions: DEVICE: ALOA IgG-Elisa|DEVICE: ALOA IgG-AtheroAbzyme
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Exercise Combination on Pain, Function and Proprioception in Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Stretching and Aerobic Exercise at Clinic|OTHER: Strenghthening and Aerobic Exercise|OTHER: Strengthening, Stretching and Aerobic Exercises at clinic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 or IDH2 Mutations
Status: ACTIVE_NOT_RECRUITING
Conditions: Cholangiocarcinoma|Chondrosarcoma|Glioma|Any Solid Tumor
Interventions: DRUG: LY3410738|DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study Evaluating Safety of Pentoxifylline and Celecoxib in Patients With Grand-Mal Epilepsy Treated by Phenytoin Monotherapy
Status: RECRUITING
Conditions: Epilepsy
Interventions: DRUG: Phenytoin|DRUG: Pentoxifylline 400 MG|DRUG: Celecoxib 200mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Long-term Safety and Efficacy of EnXtra (E-AG-01) in Healthy Adults
Status: COMPLETED
Conditions: Caffeine Dependence
Interventions: DIETARY_SUPPLEMENT: Alpinia Galanga|DIETARY_SUPPLEMENT: Alpinia Galanga|DIETARY_SUPPLEMENT: Microcellulose crystalline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetics, Safety and Tolerability of Escalating Rifapentine Doses in Healthy Volunteers
Status: COMPLETED
Conditions: Tuberculosis|Tuberculosis, Pulmonary
Interventions: DRUG: Rifampin & midazolam|DRUG: rifapentine & midazolam|DRUG: rifapentine & midazolam|DRUG: rifapentine & midazolam|DRUG: rifapentine and midazolam|DRUG: rifapentine and midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Cross-sectional Study to Assess the Effectiveness and Safety of Ofatumumab (Kesimpta®) in Patients With Relapsing Multiple Sclerosis in the Spanish Clinical Practice
Status: RECRUITING
Conditions: Relapsing Forms of Multiple Sclerosis
Interventions: OTHER: ofatumumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparison of the Effectiveness of Two Approaches in Achieving Smoking Abstinence
Status: COMPLETED
Conditions: Smoking
Interventions: BEHAVIORAL: quit immediately (QI)|BEHAVIORAL: cut down to quit (CDTQ)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation in Vivo of Mouthwash With Nanoencapsulated Fluoride
Status: COMPLETED
Conditions: Dental Caries
Interventions: OTHER: Mouthwash 100% Nano-F|OTHER: Mouthwash 50% Nano-F|OTHER: Mouthwash standard|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Preload on Bladder Retention Volume During Spinal Anesthesia
Status: COMPLETED
Conditions: Diuresis|Bladder Retention Volume|Hypotension
Interventions: OTHER: placebo|DRUG: Ringers Lactate|DRUG: HaemoHES 6%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Effect of Vitamin D Supplementation on Mental Health: An Exploratory Study on A University Students Suffering From Vitamin D Deficiency
Status: NOT_YET_RECRUITING
Conditions: Psychiatric Disorder
Interventions: DRUG: Vit D|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arsenic Trioxide in Treating Patients With Relapsed or Refractory Lymphoma or Leukemia
Status: TERMINATED
Conditions: Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Prolymphocytic Leukemia|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Splenic Marginal Zone Lymphoma|Waldenström Macroglobulinemia
Interventions: DRUG: arsenic trioxide|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of PET Probe [68Ga]CBP8 in the Detection of Radiation Induced Tissue Injury
Status: RECRUITING
Conditions: Lung Cancer|Radiation Fibrosis|Radiation Induced Lung Injury|Pancreas Cancer
Interventions: DRUG: [68Ga]CBP8
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Chronic Pain Master Protocol (CPMP): A Study of LY3016859 in Participants With Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: LY3016859|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intracavernosal Injection of Botulinum Toxin Type A in the Treatment of Vascular Erectile Dysfunction
Status: COMPLETED
Conditions: Vasculogenic Erectile Dysfunction
Interventions: DRUG: Botulinum Toxin Type A|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CEV With/Without Periocular Carboplatin Chemotherapy for Extraocular Retinoblastoma
Status: COMPLETED
Conditions: Retinoblastoma
Interventions: DRUG: carboplatin periocular injection|DRUG: CEV chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRISM for Parents of Children With Cancer Promoting Resilience in Stress Management (PRISM) Intervention for Parents of Children With Cancer
Status: COMPLETED
Conditions: Pediatric Cancer
Interventions: BEHAVIORAL: Promoting Resilience in Stress Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pilot Study Testing a New Strategy for Management of Spontaneous Preterm Birth
Status: UNKNOWN
Conditions: Preterm Labor
Interventions: DRUG: Montelukast|DRUG: Placebo|OTHER: urine and vaginal secretions sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Efficacy of Arfolitixorin Versus Leucovorin in Combination With 5 Fluorouracil, Oxaliplatin, and Bevacizumab in Patients With Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colo-rectal Cancer
Interventions: DRUG: Arfolitixorin|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Amlodipine-Folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine
Status: UNKNOWN
Conditions: Essential Hypertension
Interventions: DRUG: Amlodipine-FA tablet,low dose group|DRUG: Amlodipine-FA tablet,high dose group|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Plasma Levels of N-Methanocarbathymidine (N-MCT) in Normal Patients
Status: UNKNOWN
Conditions: Toxicity
Interventions: DRUG: N-Methanocarbathymidine|OTHER: Placebo Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Recombinant Human Angiotensin-converting Enzyme 2 (rhACE2) as a Treatment for Patients With COVID-19
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: Recombinant human angiotensin-converting enzyme 2 (rhACE2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Efficacy and Malaria TRANSmission After Artemisinin Combination Therapy 2 (TRANSACT2)
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Mefloquine - Artesunate|DRUG: Artemether-lumefantrine combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Recovery in Trauma Patients by Integrating Enhanced Nutrition Delivery
Status: NOT_YET_RECRUITING
Conditions: Trauma|Critical Illness
Interventions: DIETARY_SUPPLEMENT: Nutrition Supplements - Fresubin KCAL Drinks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology During IVF/ICSI
Status: COMPLETED
Conditions: In Vitro Fertilization|Intracytoplasmic Sperm Injection|Infertility
Interventions: DRUG: Triptorelin acetate|DRUG: Cetrorelix|DRUG: recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin|DRUG: Human Chorionic Gonadotropin (hCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of NICE Support Program on Frailty and Quality of Life in Patients With Heart Failure
Status: COMPLETED
Conditions: Frailty|Quality of Life
Interventions: BEHAVIORAL: NICE Support Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lenalidomide for Lean Body Mass and Muscle Strength in Inflammatory Cancer Cachexia Syndrome
Status: COMPLETED
Conditions: Cancer Cachexia Syndrome
Interventions: DRUG: Lenalidomide|DRUG: Lenalidomide|OTHER: basic cachexia management (prokinetics, physical activity counselling, nutritional counselling)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of a Multiple Thrust Instrument to a Single Thrust Instrument in Treating the Low Back
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: DEVICE: Activator IV single impulse instrument|DEVICE: Multiple thrust Impulse adjusting instrument
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Botulinum Toxin Injection for Treatment of Temporomandibular Joint Dislocation
Status: RECRUITING
Conditions: Dislocation of Temporomandibular Joint TMJ|Subluxation of Temporomandibular Joint
Interventions: DRUG: Botulinum toxin type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Hamstring Stretching With and Without Neural Load on Flexibility, Maximum Isometric Strength and Tibial Nerve Pressure Pain Threshold
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Hamstring stretching program with neural load|OTHER: Hamstring stretching program without neural load
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Flax Lignans and Heart Health
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: secoisolariciresinol diglucoside-containing extract of flaxseed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Learn More About the Physical Activity Level of Patients Suffering From Hemophilia A Treated With Damoctocog Alfa Pegol (LIFE ACTIVE Study)
Status: ACTIVE_NOT_RECRUITING
Conditions: Hemophilia A
Interventions: DRUG: Damoctocog alfa pegol (Jivi, BAY94-9027)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 1 Continuous Intravenous Infusion Study of Terameprocol (EM-1421) in Subjects With Refractory Solid Tumors
Status: TERMINATED
Conditions: Refractory Solid Tumors|Lymphoma
Interventions: DRUG: Terameprocol (EM-1421)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM
Status: RECRUITING
Conditions: Glioblastoma Multiforme|Astrocytoma, Grade III
Interventions: DRUG: ADV/HSV-tk (gene therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GATE1: A Multicenter Phase II Study of Pirtobrutinib, Rituximab and Venetoclax Combination Therapy for Patients With Previously Untreated Mantle Cell Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Pirtobrutinib|DRUG: Rituximab|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Measuring the Effectiveness of Combined Modulated Ultrasound and Electric Current Stimulation as an Adjunctive Treatment in Treating Diabetic Foot Ulcers
Status: UNKNOWN
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: BRH-A2 wound healing device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-Dose Glucagon and Advanced Hybrid Closed-Loop System for Prevention of Exercise-Induced Hypoglycaemia in People With Type 1 Diabetes
Status: RECRUITING
Conditions: Type 1 Diabetes|Hypoglycemia
Interventions: DRUG: GlucaGen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Different Education Methods Before Invasive Urodynamics
Status: COMPLETED
Conditions: Urologic Diseases|Urodynamics
Interventions: OTHER: Patients in the Brochure Education Group|OTHER: Patients in the Video Education Group|OTHER: Patients in the Brochure-Supported Video Education Group|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Extended-Release Oxybutynin Chloride on Vasomotor Symptoms in Healthy Post-Menopausal Women
Status: COMPLETED
Conditions: Menopause|Hot Flashes
Interventions: DRUG: Placebo|DRUG: Oxybutynin chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diuretics and Volume Overload in Early CKD
Status: RECRUITING
Conditions: Chronic Kidney Disease|Hypertension
Interventions: DRUG: Diuretic augmentation (hydrochlorothiazide, chlorthalidone, furosemide, torsemide, or bumetanide)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Aspirin on Recurrence and Survival in Colon Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Colon Cancer|Adjuvant Therapy
Interventions: DRUG: Acetylsalicylic acid|DRUG: Placebo Acetylsalicylic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation Use in Acute Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: active rTMS|DEVICE: sham rTMS|BEHAVIORAL: conventional stroke therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of CPAP on Breath Hold and Chest Movement in Normal Volunteers
Status: UNKNOWN
Conditions: Healthy Volunteers|Effect of CPAP on Chest Movement
Interventions: BEHAVIORAL: Chest wall movement assessment without CPAP|BEHAVIORAL: Breath hold assessment without CPAP|PROCEDURE: Chest wall movement assessment with CPAP|PROCEDURE: Breath hold assessment with CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate the Efficacy and Safety of KBP-042 in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Daily injection of KBP/placebo for 12 weeks as add-on to metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Flooring for Injury Prevention Trial
Status: COMPLETED
Conditions: Accidental Falls|Bone Fracture|Traumatic Brain Injury|Head Injuries, Closed|Nursing Homes
Interventions: OTHER: SmartCell flooring|OTHER: Plywood flooring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rigid Video Stylet Vs Conventional Lightwand Intubation
Status: UNKNOWN
Conditions: Hoarseness|Intubation|Sorethroat
Interventions: DEVICE: Conventional lightwand intubation|DEVICE: Rigid video stylet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Tozadenant to Treat End of Dose Wearing Off in Parkinson's Patients
Status: TERMINATED
Conditions: Idiopathic Parkinson's Disease
Interventions: DRUG: tozadenant|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT