pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparison of Efficacy, Safety, and Tolerability of ITCA 650 to Empagliflozin and Glimepiride as add-on Metformin
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: ITCA 650 20/60 mcg/day|DRUG: Empagliflozin (oral)|DRUG: Glimepiride (oral)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis
Status: COMPLETED
Conditions: Chemical Injuries|Unspecified Complication of Corneal Transplant|Autoimmune Diseases|Ocular Cicatricial Pemphigoid|Stevens Johnson Syndrome|Lupus Erythematosus, Systemic|Rheumatoid Arthritis|Other Autoimmune Diseases
Interventions: DRUG: Riboflavin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CPG Styles Study: A Study of the Safety of the Contour Profile Gel Breast Implants (CPG Styles Study)
Status: COMPLETED
Conditions: Breast Augmentation|Breast Reconstruction|Breast Revision
Interventions: DEVICE: The Contour Profile Gel (CPG) breast implants
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tislelizumab in Combination With GP or TPC Regimen for the Treatment of Nasopharyngeal Carcinoma With Bone Metastasis.
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: GP combined with Tislelizumab|DRUG: TPC combined with Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Drug IMGN632 in Children With Leukemia That Has Come Back After Treatment or is Difficult to Treat
Status: WITHDRAWN
Conditions: Recurrent Acute Myeloid Leukemia|Recurrent B Acute Lymphoblastic Leukemia|Recurrent Mixed Phenotype Acute Leukemia|Recurrent T Acute Lymphoblastic Leukemia|Refractory Acute Myeloid Leukemia|Refractory B Acute Lymphoblastic Leukemia|Refractory Mixed Phenotype Acute Leukemia|Refractory T Acute Lymphoblastic Leukemia
Interventions: DRUG: Anti-CD123 ADC IMGN632|PROCEDURE: Bone Marrow Aspiration and Biopsy|DRUG: Cytarabine|DRUG: Fludarabine Phosphate|DRUG: Hydrocortisone Sodium Succinate|DRUG: Liposome-encapsulated Daunorubicin-Cytarabine|DRUG: Methotrexate|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Web-based CBT for Symptoms of Mild-to-Moderate Anxiety and Depression in Youth With Chronic Illness
Status: COMPLETED
Conditions: Depression|Anxiety|Inflammatory Bowel Disease|Systemic Lupus Erythematosus|Juvenile Idiopathic Arthritis
Interventions: BEHAVIORAL: Web-based Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Surrogate Markers for Sudden Cardiac Death in Patients With Diabetes Mellitus and End Stage Renal Disease
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2|End Stage Renal Disease
Interventions: DEVICE: 12 lead Holter|DEVICE: CGM Continuous Glucose Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cognitive Behavior Therapy for Insomnia (CBT-I) in Persons With Traumatic Brain Injury (TBI)
Status: COMPLETED
Conditions: TBI|Insomnia
Interventions: BEHAVIORAL: Sleep Education|BEHAVIORAL: Cognitive Behavior Therapy for Insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Message-Based Psychotherapy and Digital Treatment Sequences for Depression
Status: COMPLETED
Conditions: Study Adherence|Depressive Disorder
Interventions: BEHAVIORAL: Video-chat psychotherapy (VCP)|BEHAVIORAL: Message-based psychotherapy (MBP)|BEHAVIORAL: Message-based psychotherapy with monthly video chat (Premium Plan)|BEHAVIORAL: Message-based psychotherapy with weekly video chat (Ultimate Plan)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase-II Study Of Raltitrexed/Oxaliplatin Plus Radiotherapy Versus Radiotherapy In Subjects With Inoperable Esophageal Cancer
Status: UNKNOWN
Conditions: Inoperable Esophageal Cancer Stage I-III
Interventions: DRUG: Raltitrexed|DRUG: Oxaliplatin|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib and Azacitidine in Treating Patients With Relapsed or Refractory T-Cell Lymphoma
Status: COMPLETED
Conditions: Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Hepatosplenic T-cell Lymphoma|Peripheral T-cell Lymphoma|Post-transplant Lymphoproliferative Disorder|Prolymphocytic Leukemia|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Small Intestine Lymphoma|T-cell Large Granular Lymphocyte Leukemia
Interventions: DRUG: azacitidine|DRUG: bortezomib|PROCEDURE: Correlative studies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adherence, Efficacy and Tolerance of Once-a-day Nevirapine-based Regimen in HIV-1 Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: BEHAVIORAL: Nevirapine from twice-a-day to once-a-day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Urinary Retention in Patients After Noncardiac Surgery and Reversal of Neuromuscular Block
Status: RECRUITING
Conditions: Neuromuscular Blockade
Interventions: DRUG: Neostigmine with glycopyrrolate|DRUG: Sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post Transplant Donor Lymphocyte Infusion
Status: TERMINATED
Conditions: Leukemia, Myeloid, Chronic|Lymphomas|Multiple Myeloma|Myelodysplastic Syndrome|Leukemia, Lymphocytic, Acute|Leukemia, Lymphocytic, Chronic|AML
Interventions: PROCEDURE: Donor Lymphocyte Infusion|DRUG: Induction Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study for 24-months of Physical Training Introduced in Lifestyle of Patients With FSHD : Tolerance, Sustainability and Efficiency of Unsupervised Training Program.
Status: COMPLETED
Conditions: Muscular Dystrophy, Facioscapulohumeral
Interventions: OTHER: FSHD training
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess the Efficacy, Safety and Tolerability of Idebenone in the Treatment of Friedreich's Ataxia
Status: COMPLETED
Conditions: Friedreich's Ataxia
Interventions: DRUG: Idebenone|DRUG: Idebenone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Hydroxychloroquine in Adult Patients With COVID-19
Status: COMPLETED
Conditions: Coronavirus Infection
Interventions: DRUG: Hydroxychloroquine Sulfate 200 MG [Plaquenil]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Post-market Study Examining the Effectiveness of the EcoFit®
Status: NOT_YET_RECRUITING
Conditions: Degenerative Joint Disease|Femoral Fracture|Osteoarthritis, Hip|Traumatic Arthritis
Interventions: DEVICE: EcoFit® Total Hip System with implacross® E Polyethylene
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Web-Based Training on HbA1c, Quality of Life and Depression Levels in Adolescents With Type 1 Diabetes
Status: COMPLETED
Conditions: Mental Disorder in Adolescence|Behavioral Symptoms|Problem Behavior
Interventions: OTHER: The web-based Watson's Human Care Theory oriented training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: For Prevention of Diarrhea in Patients Diagnosed With Metastatic Colorectal Cancer Treated With Chemotherapy
Status: TERMINATED
Conditions: Neoplasm Metastasis|Colorectal Neoplasms
Interventions: DRUG: Celecoxib|DRUG: Irinotecan|DRUG: 5-fluorouracil|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Low Molecular Weight Heparin in Prevention of Recurrent Arteriovenous Graft Thrombosis in Chronic Hemodialysis Patients.
Status: UNKNOWN
Conditions: Hemodialysis Patients
Interventions: DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy/Safety of Amlodipine Plus Losartan Versus Losartan in Patients With Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Amlodipine plus Losartan|DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of NADPH Oxidase and Creatine Supplementation on Microvascular Blood Flow Regulation
Status: COMPLETED
Conditions: Endothelial Dysfunction
Interventions: OTHER: Creatine Monohydrate|OTHER: Maltodextrin (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot,Raltegravir Versus NRTIs as a Backbone Switched From a Stable Boosted PI Regimen
Status: COMPLETED
Conditions: Virus Diseases|HIV
Interventions: DRUG: Switch NRTIs as a Backbone to Raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Response to Hypoxia at Rest and During Exercise in a Healthy Subject After a Cryostimulation Exposure
Status: NOT_YET_RECRUITING
Conditions: Hypoxia|Cryostimulation|Metabolism|Autonomic Nervous System|Exercise|Adaptation
Interventions: OTHER: Cryostimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Safety and Efficacy Study Comparing the Combination Treatments of Verteporfin Therapy Plus One of Two Different Doses of Intravitreal Triamcinolone Acetonide and the Verteporfin Therapy Plus Intravitreal Pegaptanib
Status: COMPLETED
Conditions: Macular Degeneration|Choroidal Neovascularization
Interventions: DRUG: Verteporfin photodynamic therapy|DRUG: Pegaptanib|DRUG: Triamcinolone acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Insulin-free Cow Milk Formula in Prevention of Type 1 Diabetes Associated Autoimmunity - FINDIA Pilot Study
Status: COMPLETED
Conditions: Beta-cell Autoimmunity
Interventions: DIETARY_SUPPLEMENT: Cow's milk formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tamoxifen, Ovarian Ablation, and/or Combination Chemotherapy in Treating Premenopausal Women With Stage I, Stage II, or Stage IIIA Invasive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: fluorouracil|DRUG: goserelin acetate|DRUG: leuprolide acetate|DRUG: methotrexate|DRUG: tamoxifen citrate|PROCEDURE: conventional surgery|PROCEDURE: laparoscopic surgery|PROCEDURE: oophorectomy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Fully Coated, Removable, Self-expanding Oesophageal Stents for Preventing Strictures Following Complete Barretts Excision.
Status: COMPLETED
Conditions: Constriction, Pathological
Interventions: DEVICE: Fully coated, removable , self-expanding oesophageal stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Methylprednisolone for Hantavirus Cardiopulmonary Syndrome
Status: COMPLETED
Conditions: Hantavirus Infections
Interventions: DRUG: Methylprednisolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HELPing Older People With Very Severe Chronic Obstructive Pulmonary Disease Towards the End of Their Lives: Developing, Piloting and Refining a Practical Intervention (HELP-COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: OTHER: HELP-COPD action plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Intra-Articular Corticosteroid Injections on Clinical Outcomes in Patients With Operative Distal Radius Fractures
Status: NOT_YET_RECRUITING
Conditions: Wrist Fractures|Intraarticular Injection
Interventions: DRUG: Triamcinolone Acetonide|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of PENG Block Combined to LFCN Block on the Quality of Recovery After Total Hip Replacement
Status: COMPLETED
Conditions: Total Hip Replacement Surgery|Postoperative Pain
Interventions: DRUG: Ropivacaine 0.5% Injectable Solution|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intramuscular Phenylephrine HCL for Prevention of Spinal Anesthesia Induced Hypotension
Status: COMPLETED
Conditions: Hypotension|Anesthesia
Interventions: DRUG: Phenylephrine Hydrochloride 4 mg|DRUG: Phenylephrine Hydrochloride 8 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Caffeine's Effect on Regadenoson Administration With Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI)
Status: COMPLETED
Conditions: Coronary Artery Disease (CAD)
Interventions: DRUG: regadenoson|DRUG: overencapsulated caffeine|RADIATION: technetium|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Lymphedema Upper Limb of Breast Cancer Through Muscle Strengthening Associated With Complex Physical Therapy
Status: COMPLETED
Conditions: Lymphedema
Interventions: OTHER: complex physical therapy|OTHER: Evaluate treatment of lymphedema, with in the quality of life and depression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CLAG-GO for Patients With Persistent, Relapsed or Refractory AML
Status: RECRUITING
Conditions: Acute Myeloid Leukemia, Adult|Acute Myeloid Leukemia Recurrent|Acute Myeloid Leukemia, Relapsed, Adult
Interventions: DRUG: Cladribine, Cytarabine, and Granulocyte-Colony Stimulating Factor with Fractionated Gemtuzumab Ozogamicin (CLAG-GO)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Iron Supplements on the Growth of Enteric Pathogens
Status: COMPLETED
Conditions: Iron-deficiency|Iron Deficiency Anaemia Due to Dietary Causes|Iron Deficiency Anemia Treatment|Iron Deficiency Anemia
Interventions: DIETARY_SUPPLEMENT: Ferrous sulfate|DIETARY_SUPPLEMENT: Ferrous sulfate-enriched Aspergillus oryzae (Ao iron)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Oral Glucose in Pain Alleviation Among Term Neonates
Status: COMPLETED
Conditions: Pain
Interventions: OTHER: 5% glucose|OTHER: 30% glucose|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study to Investigate ABP 654 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: ABP 654|DRUG: Ustekinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of AZD6094 (Volitinib) in Combination With Docetaxel, in Advanced Gastric Adenocarcinoma Patients With MET Overexpression as a Second-line Treatment
Status: COMPLETED
Conditions: Advanced Gastric Adenocarcinoma
Interventions: DRUG: AZD6094|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Suprachoroidal Injection of Triamcinolone Acetonide for Management of Diabetic Macular Edema
Status: UNKNOWN
Conditions: Safety|Efficacy
Interventions: PROCEDURE: Intravitreal injection (4mg/0.1ml)|PROCEDURE: Superachoroidal injection (4 mg/0.1ml)|PROCEDURE: Suprachoroidal injection (2mg/0.1ml)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Culture for the Diagnosis of Neonatal Sepsis
Status: RECRUITING
Conditions: Neonatal Sepsis, Early-Onset|Culture Positive Neonatal Sepsis|Culture Negative Neonatal Sepsis|Clinical Sepsis|Microbial Disease|Neonatal Infection|Microbial Colonization|Neonatal Sepsis, Late-Onset
Interventions: DIAGNOSTIC_TEST: Molecular Culture
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Blueberry Juice Consumption on Cognitive Function in Healthy Older People
Status: COMPLETED
Conditions: Cognitive Aging
Interventions: DIETARY_SUPPLEMENT: Blueberry|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Free Gingival Grafts (FGGs) in Mandibular Posterior Sites
Status: ACTIVE_NOT_RECRUITING
Conditions: Lack of Keratinized Tissue
Interventions: PROCEDURE: Partial thickness recipient bed|PROCEDURE: Full thickness recipient bed|DEVICE: Bone screw (FDA approved bone screw)|PROCEDURE: Periosteal sutures|PROCEDURE: Sling sutures|PROCEDURE: Sling sutures around screws
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Normal Reference Range Study With the TEG6s Heparin Neutralization Cartridge in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DIAGNOSTIC_TEST: TEG 6s Citrated K, KH, RTH, and FFH Cartridge|DIAGNOSTIC_TEST: Clauss Fibrinogen
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: IBD Self-management Website and Home Faecal Calprotectin Monitoring
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|Crohn Disease|Ulcerative Colitis|Self-care
Interventions: OTHER: My Medical record website
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Testing Nivolumab and Ipilimumab Immunotherapy With or Without the Targeted Drug Cabozantinib in Recurrent, Metastatic, or Incurable Nasopharyngeal Cancer
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma|Stage IV Nasopharyngeal Carcinoma AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Cabozantinib S-malate|PROCEDURE: Computed Tomography|BIOLOGICAL: Ipilimumab|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Study of Sorafenib and Rapamycin in Advanced Malignancies
Status: COMPLETED
Conditions: Advanced Solid Tumor
Interventions: DRUG: Sorafenib|DRUG: Rapamycin|DRUG: Rapamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Fish and Omega 3 Fatty Acids for Breast Cancer Prevention
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DIETARY_SUPPLEMENT: Lovaza-Omega 3 fatty acid capsules|OTHER: Dietary fish (canned salmon, albacore)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Antistax® in Patients With Chronic Venous Insufficiency
Status: COMPLETED
Conditions: Venous Insufficiency
Interventions: DRUG: Antistax®, low dose|DRUG: Antistax®, high dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Vaccine Study for High Risk Cancers
Status: WITHDRAWN
Conditions: Neuroblastoma|Rhabdomyosarcoma|Osteogenic Sarcoma
Interventions: BIOLOGICAL: MAGE-A1, MAGE-A3, and NY-ESO-1 Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive-Behavioral Therapy for Pain and Opioid Dependence in Methadone Maintenance Treatment
Status: COMPLETED
Conditions: Chronic Pain|Opiate Dependence
Interventions: BEHAVIORAL: Cognitive-Behavioral Therapy for Pain and Opioid Dependence|BEHAVIORAL: Methadone Drug Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reshaping the Motor Engram - An Online Crowdsourcing Study.
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BEHAVIORAL: Interference through learning of a competing motor skill.|BEHAVIORAL: No interference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Studies of Psychiatric Predisposing Factors, Treatment-related Cardiovascular Effects, and Prognostic Factors Associated With Antimuscarinic Drug (Tolterodine) for Female Overactive Bladder Syndrome
Status: COMPLETED
Conditions: Antimuscarinic Drug
Interventions: DRUG: tolterodine, solifenacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of LGX818 and Cetuximab or LGX818, BYL719, and Cetuximab in BRAF Mutant Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: LGX818|DRUG: Cetuximab|DRUG: BYL719
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Explore the Reasonable Dosage and Evaluate the Efficacy, Safety and Tolerability of HLX10 and HLX04 With or Without HLX53 in Untreated, Locally Advanced or Metastatic Hepatocellular Carcinoma Patients.
Status: NOT_YET_RECRUITING
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: HLX53 (1000mg)|DRUG: HLX53 (2000mg)|DRUG: HLX10|DRUG: HLX04|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study to Evaluate How Safe and Tolerable NBI-921352 is as an Adjunctive Therapy for Participants With SCN8A-DEE
Status: ENROLLING_BY_INVITATION
Conditions: SCN8A Developmental and Epileptic Encephalopathy Syndrome
Interventions: DRUG: NBI-921352
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venetoclax in Combination With BEAM Conditioning Regimen for ASCT in Non-Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-hodgkin Lymphoma
Interventions: DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Utilization of Different Virtual Reality Experiences
Status: COMPLETED
Conditions: Surgery|Pain, Postoperative|Anxiety|Otolaryngological Disease
Interventions: DEVICE: Oculus Quest: TRIPP|DEVICE: Oculus Quest: Angry Birds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ketogenic Dietary Interventions in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Status: COMPLETED
Conditions: ADPKD
Interventions: OTHER: Ketogenic diet|OTHER: 3-days water-fasting|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study To Evaluate D-Ribose For The Treatment of Congestive Heart Failure
Status: WITHDRAWN
Conditions: Congestive Heart Failure
Interventions: DRUG: D-ribose|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicentre Clinical Investigation of a Decision Support Algorithm for Neonatal Seizure Detection
Status: COMPLETED
Conditions: Seizures|Brain Diseases|Central Nervous System Diseases|Epilepsy|Nervous System Diseases|Neurologic Manifestations
Interventions: DEVICE: ANSeR Software System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Radiolabeled [14C]PF-02341066 Study To Investigate The Absorption, Metabolism And Excretion In Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: PF-02341066
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Biological Response of Trauma Patients to Standard Trauma Resuscitation Therapy
Status: COMPLETED
Conditions: Hemorrhagic Shock
Interventions: DRUG: Glutamine|DRUG: Ringer's Lactate|DRUG: Placebo (for Glutamine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability of HTS-519 Insert in Patients With Toenail Fungus of the Big Toenail
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: HTS-519 Insert
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Recurrent/Metastatic Head and Neck Cancer
Status: RECRUITING
Conditions: Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Interventions: BIOLOGICAL: Amivantamab|BIOLOGICAL: Pembrolizumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Behavioral Activation Intervention for Smoking Cessation in Smokers With Depressive Symptoms
Status: COMPLETED
Conditions: Cigarette Smoking
Interventions: BEHAVIORAL: Standard Treatment|BEHAVIORAL: Behavioral Activation Treatment for Smoking|DRUG: Transdermal Nicotine Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate PK and Safety Profile of Oral MAD of Separately Using TG-2349, DAG181 or Combination in Healthy Chinese Volunteers
Status: COMPLETED
Conditions: Healthy Chinese Volunteers
Interventions: DRUG: TG-2349 (400 mg) plus DAG181 (200 mg)|DRUG: DAG181 (200 mg) plus TG-2349 (400 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: STARS Breast Trial (Study of Anastrozole and Radiotherapy Sequencing)
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Pre-radiotherapy commencement of anastrozole|RADIATION: Radiotherapy|DRUG: Post radiotherapy commencement of anastrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examining the Effectiveness of Transdiagnostic, Internet-Delivered Cognitive Behaviour Therapy in New Mothers Experiencing Anxiety and Depression
Status: COMPLETED
Conditions: Depression, Postpartum|Anxiety
Interventions: BEHAVIORAL: Therapist-assisted ICBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resume Walking by an Interactive Mobile Robot of Rehabilitation After Vascular Stroke (Cerebral Vascular Stroke) in Combination With Traditional Reeducation
Status: UNKNOWN
Conditions: Stroke Sequelae
Interventions: OTHER: Clinical evaluation|OTHER: Intervention - with Robot|OTHER: Intervention - without Robot|OTHER: quality of life assessment|OTHER: An assessment of patient acceptance of robotic rehabilitation|OTHER: cognitive assessment|OTHER: An evaluation of how to use the robot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Treatment of Survivors After Botulism Outbreak
Status: COMPLETED
Conditions: Respiratory Failure|Botulism
Interventions: DRUG: Botulinum AntiToxin|PROCEDURE: neuro-electrophysiologic study, repetitive nerve stimulation|PROCEDURE: Protocol early weaning ventilator after recovery of repetitive nerve stimulation and stable negative inspiratory pressure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tandutinib in Treating Patients With Recurrent or Progressive Glioblastoma
Status: COMPLETED
Conditions: Adult Brain Tumor|Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Recurrent Adult Brain Tumor
Interventions: PROCEDURE: conventional surgery|DRUG: tandutinib|OTHER: pharmacological study|OTHER: Tissue samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Nab-Paclitaxel Combined With Cisplatin in Second or Later-Line Treatment in Advanced Biliary Tract Cancers
Status: UNKNOWN
Conditions: Advanced Biliary Tract Cancers
Interventions: DRUG: cisplatin and nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardenilimab Combined With Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma|Neoadjuvant Therapies
Interventions: DRUG: Cardenilimab Combined With Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maintenance Metronomic Chemotherapy for Metastatic Colorectal Carcinoma
Status: TERMINATED
Conditions: Colorectal Cancer Metastatic
Interventions: DRUG: CAPECITABINE, CELECOXIB and METHOTREXATE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of Isosorbide-5-Mononitrate Extended-Release Tablets Under Fed Conditions in Healthy Subjects
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: IS-5-MN R|DRUG: IS-5-MN T1|DRUG: IS-5-MN T2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Rivaroxaban From Repatoxaban 10 mg Tablets (Horus for Pharmaceutical Industries, Egypt) and Xarelto® 10 mg Tablets (Janssen Pharm., Licensed From: Bayer Healthcare, Germany)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Repatoxaban|DRUG: Xarelto
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics and Safety of WAL2014 (Talsaclidine) Administered Orally to Healthy Adult Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: WAL2014|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: tRNS Combined to Cognitive Training in Children With Dyscalculia
Status: RECRUITING
Conditions: Developmental Dyscalculia
Interventions: DEVICE: Brainstim DLPFC|DEVICE: Brainstim PPC|DEVICE: Brainstim Sham|BEHAVIORAL: Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influenced the Type of Laryngoscopy the Intraoperative Nerve Monitoring During Thyroid Surgery
Status: COMPLETED
Conditions: Thyroid|Airway Morbidity
Interventions: DEVICE: CMAC Videolaryngoscope|DEVICE: Macintosh Laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sonazoid-Enhanced Ultrasound in Detecting Sentinel Lymph Node in Patients With Cutaneous Melanoma
Status: TERMINATED
Conditions: Cutaneous Melanoma|Melanoma
Interventions: PROCEDURE: Sentinel Lymph Node Biopsy|DEVICE: Ultrasonography|DRUG: Sonazoid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Endoscopic Ultrasound Shear Wave vs Transient Elastography for Liver Steatosis: The RUMIPAMBA Trial
Status: NOT_YET_RECRUITING
Conditions: Liver Steatosis
Interventions: DEVICE: Transparietal ultrasound (US)-based shear wave elastography (SWE)|DEVICE: Vibration-controlled transient elastography (VCTE)|DEVICE: Endoscopic ultrasound (EUS)-guided shear wave elastography (SWE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects on Major Organ Complications on Esophagectomy of New Anesthetic ERAS Strategy: a Prospective Investigation
Status: UNKNOWN
Conditions: Esophageal Cancer|Complication, Postoperative|Anesthesia
Interventions: PROCEDURE: Fluid therapy optimization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Digital vs Conventional Impressions Study
Status: COMPLETED
Conditions: Dental Prosthesis
Interventions: PROCEDURE: Conventional impression|PROCEDURE: Digital Scan 1|PROCEDURE: Digital Scan 2|PROCEDURE: Digital Scan 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Lidocaine on Postoperative Pain in Elderlypatients Undergoing Colorectal Cancer Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Colorectal Cancer
Interventions: DRUG: lidocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fentanyl and Clonidine for Analgesia During Hypothermia in Term Asphyxiated Infants
Status: COMPLETED
Conditions: Asphyxia Neonatorum
Interventions: DRUG: Fentanyl|DRUG: Fentanyl and clonidine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vorinostat and Decitabine in Treating Patients With Advanced Solid Tumors or Relapsed or Refractory Non-Hodgkin's Lymphoma, Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, or Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Blastic Phase Chronic Myelogenous Leukemia|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Secondary Acute Myeloid Leukemia|Splenic Marginal Zone Lymphoma|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: vorinostat|DRUG: decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension Study of the Efficacy and Safety of Oral SCIO-469 in Relapsed, Refractory Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: SCIO-469|DRUG: SCIO-469 and bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of Analgesic Effect From One Transcranial Magnetic Stimulation(TMS)Treatment Following Vaginal Reconstructive Surgery.
Status: WITHDRAWN
Conditions: Pain
Interventions: DEVICE: Active Transcranial Magnetic Stimulation|DEVICE: Sham Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of the Variation of the Retinal Vascularization After a Prolonged Effort
Status: COMPLETED
Conditions: Retinal Vascular Disorder|Sport Injury
Interventions: DIAGNOSTIC_TEST: Color retinography|DIAGNOSTIC_TEST: OCT-A|DIAGNOSTIC_TEST: Blood pressure measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Safety and Efficacy, Including Pharmacokinetics, of NNC 0129-0000-1003 When Administered for Treatment and Prophylaxis of Bleeding in Subjects With Haemophilia A
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A
Interventions: DRUG: turoctocog alfa pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Daily Disposable Silicone Hydrogel Multifocal Contact Lens in Myopes and Hyperopes
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: JJVC Investigational Multifocal Contact Lenses manufactured in senofilcon A C3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial to Slow the Progression of Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Diabetes Management Package (DMP)|BEHAVIORAL: M-POWER Rewards
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Relative Bioavailability Study to Assess Two Solid Formulations Compared to an Oral Solution of AZD3293 in Healthy Male and Non-Fertile Female Subjects
Status: COMPLETED
Conditions: Healthy Volunteers|Pharmacologic Action
Interventions: DRUG: AZD3293 oral solution|DRUG: AZD3293 tablet formulation A|DRUG: AZD3293 tablet formulation B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: FOLFIRINOX in Metastatic High Grade Gastroenteropancreatic Neuroendocrine Carcinomas
Status: TERMINATED
Conditions: Gastro-enteropancreatic Neuroendocrine Tumor|Pancreatic Cancer|Neuroendocrine Carcinomas of Pancreas|Islet Cell Carcinoma
Interventions: DRUG: FOLFIRINOX|DRUG: Granulocyte colony-stimulating factor (G-CSF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Follow-up NIRS-IVUS Imaging of Pre-existing Carotid Stents
Status: COMPLETED
Conditions: Carotid Atherosclerosis|Carotid Artery Stenting|Atherosclerotic Plaque|Near Infrared Spectroscopy|Restenosis
Interventions: DIAGNOSTIC_TEST: Near-infrared spectroscopy and intravascular ultrasound (NIRS-IVUS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Community-Based Health Coach to Improve Access to Germline Genetic Testing Among African American Men With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Carcinoma
Interventions: OTHER: Educational Intervention|OTHER: Genetic Testing|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy Study of Icotinb in Non-small Cell Lung Cancer (NSCLC) Patients
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Icotinib|DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Joint Crisis Plans or Crisis Cards for People With Severe Mental Disorders to Reduce Coercion in Psychiatric Care.
Status: UNKNOWN
Conditions: Schizophrenia|Bipolar Disorder|Schizoaffective Disorder
Interventions: BEHAVIORAL: joint crisis plan|BEHAVIORAL: crisis card
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial To Evaluate RPh201 In Treatment Of Partial Thickness Burn
Status: WITHDRAWN
Conditions: Second Degree Burn Less Than 5%TBSA|Partial Thickness Burn
Interventions: DRUG: RPh201, botanical drug product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Calcific Total Occlusions in Peripheral Artery Disease
Status: RECRUITING
Conditions: Chronic Total Occlusion of Artery of the Extremities
Interventions: DEVICE: SoundBite Crossing System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation and Comparison of Scores for Prediction of RIsk for Post-operative Major Morbidity After Cholecystectomy in Acute Calculous Cholecystitis (SPRIMACC)
Status: COMPLETED
Conditions: Acute Cholecystitis
Interventions: PROCEDURE: Early Cholecystectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reducing Environmental Tobacco Smoke in Neonatal Intensive Care Unit (NICU) Infants' Homes
Status: COMPLETED
Conditions: Infant Environmental Tobacco Smoke Exposure
Interventions: BEHAVIORAL: Motivational Interviewing intervention|BEHAVIORAL: Usual Care|BEHAVIORAL: Usual Care - Reduced Measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Erlotinib in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Recurrent Non-small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: DRUG: erlotinib hydrochloride|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerance, Pharmacokinetics and Preliminary Efficacy of T0001 in RA (Rheumatoid Arthritis)
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: T0001|DRUG: T0001|DRUG: T0001|DRUG: T0001|DRUG: Enbrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictive Study of Serum Endocan for Hemorrhagic Transformation After Reperfusion Therapies in Acute Ischemic Stroke
Status: UNKNOWN
Conditions: Acute Ischemic Stroke
Interventions: DIAGNOSTIC_TEST: enzyme-linked immunosorbent assay(ELISA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vortioxetine, 5, 10, and 20 mg, Relapse Prevention Study in Adults With Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Vortioxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT