pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Bioequivalence Study of Lamotrigine Dispersible/Chewable Tablets 5mg×5 Compared With Lamotrigine Compressed Tablet 25mg in Chinese Healthy Male Subjects
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Lamotrigine Dispersible/Chewable tablets 5mg*5|DRUG: Lamotrigine Compressed tablet 25mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurosensory Abnormalities in SymptomAtic Ocular Surface Patients (NASA)
Status: ENROLLING_BY_INVITATION
Conditions: Dry Eye|Neuropathic Pain
Interventions: OTHER: Hyperosmolar Response|OTHER: Proparacaine Challenge Test|OTHER: Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) Optional; only for Contact Lens Wearers|OTHER: Ocular Pain Assessment Survey (OPAS)|OTHER: Visual Analogue Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Pioglitazone Administered to Patients With Adrenomyeloneuropathy
Status: COMPLETED
Conditions: Adrenomyeloneuropathy|X-linked Adrenoleukodystrophy
Interventions: DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Vitamin D Administration to Premature Infants on Vitamin D Status and Respiratory Morbidity
Status: COMPLETED
Conditions: Other Preterm Infants|Vitamin D Deficiency|Bronchiolitis|Asthma|Pneumonia
Interventions: DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Self-administered tDCS in Patients With MDD
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: tDCS treatment|DRUG: Antidepressant Drug(escitalopram)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Adaptive Servo Ventilation and Oxygen Therapy in Central Sleep Apnea Patients
Status: COMPLETED
Conditions: Chronic Heart Failure|Sleep Apnea
Interventions: DEVICE: Adaptive servo ventilation|DEVICE: Nocturnal oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Chemoradiotherapy With Capecitabine Plus Irinotecan in Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Neoplasm|Neoadjuvant Therapy
Interventions: DRUG: Capecitabine, Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Simplified: A Trial to Compare the Efficacy of Standard of Care Combination Antiretroviral Therapy With a Simplified Dolutegravir Monotherapy in Patients With a Primary HIV-1 Infection
Status: UNKNOWN
Conditions: Monotherapy|Dolutegravir|Primary HIV Infection|Treatment Efficacy
Interventions: DRUG: Dolutegravir|DRUG: Standard of care combinational antiretroviral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic (PK) Study of Single-dose Rosuvastatin and Tipranavir/Ritonavir in Healthy Subjects
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Tipranavir/Ritonavir|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ATL1102 or Placebo in Participants With Non-ambulatory Duchenne Muscular Dystrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: ATL1102 25mg|DRUG: ATL1102 50mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preemptive Zepatier Treatment in Donor HCV Positive to Recipient HCV Negative Cardiac Transplant
Status: WITHDRAWN
Conditions: Cardiac Transplant Disorder|Hepatitis C
Interventions: DRUG: Combindation treatment with Grazoprevir and Elbasvir fixed dose combination tablet, with or without ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Software for Alternative Communication
Status: COMPLETED
Conditions: Speech Impairment
Interventions: OTHER: Presentation of alternative communication application|OTHER: Familiarization with the software interface|OTHER: Test of the software|OTHER: Answer the questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Influenza A/H3N2 Vaccine in Patients With Rheumatologic Diseases
Status: COMPLETED
Conditions: Systemic Lupus|Sjogren's Syndrome
Interventions: BIOLOGICAL: Inactivated and fragmented influenza vaccine (A / Michigan / 45/2015 (H1N1) pdm09-like virus, A / Singapore / INFIMH-16-0019 / 2016 (H3N2) -like virus; B / Phuket / 3073/2013-like virus)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trigger Point Injection in Patients With Myofascial Pain Syndrome
Status: RECRUITING
Conditions: Injection Site|Fibromyalgia
Interventions: OTHER: Ultrasound guided injection|OTHER: Blinded injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiolabeled Octreotide in Treating Children With Advanced or Refractory Solid Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Gastrointestinal Carcinoid Tumor|Islet Cell Tumor|Neuroblastoma|Pheochromocytoma|Sarcoma|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: RADIATION: 90Y-DOTA-tyr3-OCTREOTIDE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis (PsA)
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Apremilast 20mg|DRUG: Apremilast 30mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Icariin to Prevent Corticosteroid-related Memory Changes
Status: COMPLETED
Conditions: the Pharmacokinetic Profile of Icariin in Humans
Interventions: DRUG: Icariin|DIETARY_SUPPLEMENT: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Additional Treatment With EXenatide in Patients With an Acute Myocardial Infarction (the EXAMI Trial)
Status: UNKNOWN
Conditions: Patients With a First Acute Myocardial Infarction to be Treated With Primary Percutaneous Coronary Intervention (PCI).
Interventions: DRUG: Exenatide infusion|DRUG: Placebo infusion.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Therapy Optimization Trial for the Treatment of Relapsed or Refractory Brain Tumors in Children
Status: COMPLETED
Conditions: Recurrent Brain Tumors|Supratentorial PNETs|Medulloblastomas|Ependymomas
Interventions: DRUG: carboplatin|DRUG: etoposide|DRUG: temozolomide|DRUG: thiotepa, carboplatin, etoposide|DRUG: temozolomide, thiotepa|PROCEDURE: autologous stem cell transplantation|DRUG: intraventricular etoposide|DRUG: trofosfamide, etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Administration of Rifaximin on the Portal Pressure of Patients With Liver Cirrhosis and Esophageal Varices
Status: UNKNOWN
Conditions: Liver Cirrhosis|Portal Hypertension
Interventions: DRUG: Rifaximin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of High Fiber and Vegetal Protein Diet on Gut Health and Immunity Biomarkers in Prediabetic Patients
Status: RECRUITING
Conditions: Pre-diabetes
Interventions: OTHER: Normal Healthy Diet|DIETARY_SUPPLEMENT: Seaweed Group|OTHER: Placebo Diet Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Stenfilcon A Soft Contact Lens When Compared to Ocufilcon B Soft Contact Lens
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: stenfilcon A contact lens|DEVICE: ocufilcon B contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Versus Open Liver Resection for Patients With Colorectal Cancer Liver Metastases
Status: UNKNOWN
Conditions: Colorectal Liver Metastasis
Interventions: PROCEDURE: laparoscopic and robotic liver resection|PROCEDURE: open surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Involved-field Radiation Therapy for Residual or Locoregionally Recurrent Epithelial Ovarian Cancer After Definitive Treatment; Multi-institutional Clinical Trial
Status: COMPLETED
Conditions: Ovarian Cancer (Epithelial)
Interventions: RADIATION: involved-field radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Eptifibatide in Primary Percutaneous Coronary Intervention (PCI)
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: Eptifibatide facilitated PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flexible vs. Fixed Diuretic Regimen in the Management of Chronic Heart Failure: A Pilot Study
Status: RECRUITING
Conditions: Heart Failure|Heart Diseases
Interventions: OTHER: Ambulatory heart failure management with Flexible Diuretic Regimen with furosemide|OTHER: Ambulatory heart failure management with fixed dose furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HD IL-2 + Ipilimumab in Patients With Metastatic Melanoma
Status: TERMINATED
Conditions: Metastatic Melanoma
Interventions: DRUG: High Dose Interleukin-2|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Pituitary Imaging Using 18F-FET PET
Status: NOT_YET_RECRUITING
Conditions: Pituitary Adenoma
Interventions: DIAGNOSTIC_TEST: 18F-Fluoro-ethyl-tyrosine (FET) PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Supporting Our Caregivers In ADRD Learning (SOCIAL)
Status: RECRUITING
Conditions: Alzheimer's Disease and Related Dementias|Quality of Life|Caregiver Stress
Interventions: BEHAVIORAL: Mindful and Self-Compassionate Care Program (MASC)|BEHAVIORAL: Health Education Program (HEP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of SHR-A1921 With or Without Carboplatin in Subjects With Ovarian Cancer
Status: NOT_YET_RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: SHR-1921|DRUG: carboplatin|DRUG: carboplatin|DRUG: platinum-based doublet chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential Ascending Dose Study to Assess the Safety and Tolerability of REGN668 (SAR231893) in Patients With Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis
Interventions: BIOLOGICAL: REGN668|BIOLOGICAL: REGN668|BIOLOGICAL: REGN668
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open-label, Multicenter, multinAtionaL, inteRventional Clinical Trial to Assess Efficacy and Safety of the exteMporaneous combInation of Nebivolol and Ramipril in hypertenSIve pAtients
Status: RECRUITING
Conditions: Hypertension
Interventions: DRUG: Nebivolol 5 mg|DRUG: Ramipril 2.5/5/10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Using a 5 mm Telescope in Laparoscopic Cholecystectomy Reduce the Incidence of Trocar Site Hernia?
Status: ACTIVE_NOT_RECRUITING
Conditions: Cholelithiasis
Interventions: PROCEDURE: Laparoscopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Combined Chemotherapy With or Without Zoledronic Acid for Patients With Osteosarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcoma
Interventions: DRUG: cisplatin|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: methotrexate|DRUG: zoledronic acid|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center, Placebo-Controlled, Double-Blind, Randomized Trial Comparing the Virologic and Immunologic Activities of 400 Mg Nevirapine in Combination With Zidovudine Versus Zidovudine Alone in Asymptomatic HIV-1 Infected Patients With 4-12 Months of Prior Zidovudine Therapy and 200-500 CD4+ Cell
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Nevirapine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HMPL-523 in Immune Thrombocytopenia Patients
Status: COMPLETED
Conditions: Immune Thrombocytopenia (ITP)
Interventions: DRUG: HMPL-523|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study With Intravenous Busulfan And Fludarabine Myeloablative Conditioning Regimen For HLA Identical Sibling Donor HSCT
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome|Myeloproliferative Disorders|Chronic Myeloid Leukemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 1/2 Study to Determine Safety and Immunogenicity of Two COVID 19 Vaccines VB10.2129 (RBD Candidate) and VB10.2210 (T Cell Candidate) Previously Vaccinated in Healthy Adult Volunteers
Status: COMPLETED
Conditions: COVID-19|Infection Viral|Infections
Interventions: BIOLOGICAL: VB10.2129|BIOLOGICAL: VB10.2210
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Transcutaneous Vagus Nerve Stimulation for Generalized Anxiety Disorder
Status: RECRUITING
Conditions: Generalized Anxiety Disorder
Interventions: DEVICE: medication-combined transcutaneous vagus nerve stimulation|DEVICE: medication-combined sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Ultrasound for Botulinum Toxin Subscapularis Muscle Injection Guidance in Spastic Hemiplegic Shoulder Pain
Status: UNKNOWN
Conditions: Hemiplegia, Spastic
Interventions: PROCEDURE: ultrasound guided injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effect of Aclidinium on Hyperinflation and Ventilation Inhomogeneity in Severe COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Aclidinium Bromide|DRUG: Glycopyrronium Bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Heart Rate Reduction Upon Central Arterial Pressure in Younger and Older Healthy Individuals
Status: WITHDRAWN
Conditions: Blood Pressure
Interventions: DRUG: ivabradine|DRUG: metoprolol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: EVALUATION OF DIFFERENT PROPHYLACTIC INTERVENTIONS TOWARD COVID-19 IN SOLID ORGAN TRANSPLANT PATIENTS
Status: COMPLETED
Conditions: COVID-19 Pandemic|Transplant-Related Disorder
Interventions: DRUG: tixagevimab-cilgavimab(AZD7442, AstraZeneca)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Urethral Stent Irrigation in Preventing Surgical Site Infections in Adolescents With Hypospadias
Status: NOT_YET_RECRUITING
Conditions: Hypospadias
Interventions: PROCEDURE: Urethral stent tube irrigation|PROCEDURE: Urinary catheter drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tracheal Dilatation in Pediatric Patients With Acquired Tracheal Stenosis, and the Effects of Apneic Oxygenation
Status: UNKNOWN
Conditions: Apnea+Hypopnea|Tracheal Dilatation|Igel|Tracheal Stenosis|Cerebral Hypoxia|Pediatric Respiratory Diseases
Interventions: BIOLOGICAL: Apneic oxygenation - supplemental high flow oxygen administration by an apneic way
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Systemic Corticosteroid Therapy on Lens Transparency and Quantification of Lens Autofluorescence.
Status: COMPLETED
Conditions: Patients With Systemic Inflammatory Diseases Receiving for the First Time a Protracted General Corticostroid Therapy
Interventions: DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Postoperative Adjuvant Immunotherapy for Hepatocellular Carcinoma: Risk Factor Analysis and Prognostic Modelling
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Adjuvant Immunotherapy|Checkpoint Inhibitor
Interventions: DRUG: Anti-PD-1 monoclonal antibody
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Post Acute Cardiac Event Smoking (PACES) Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Coronary Syndrome|Tobacco Use
Interventions: BEHAVIORAL: BAT-CS|BEHAVIORAL: Smoking Cessation and Health & Wellness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Effect of AstraGin on Arginine Absorption and Nitric Oxide Production in Healthy Subjects
Status: UNKNOWN
Conditions: Absorption of Amino Acids and Peptides
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: AstraGin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Implant-fixed Restorations With ANKYLOS 6.6 mm Implants in the Edentulous Maxilla - A 5-year Follow-up Study
Status: COMPLETED
Conditions: Edentulous Maxilla
Interventions: DEVICE: ANKYLOS C/X implant A 6.6
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Mother's Anxiety, Fear and Prenatal Connection in the Prenatal Education Given to Pregnant Women Via Podcast During the Non-stress Test
Status: NOT_YET_RECRUITING
Conditions: Prenatal Education
Interventions: OTHER: Prenatal education management delivered via podcast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Polyphenols and Probiotics to Improve Menopausal Symptoms Via the Gut-Brain Axis
Status: RECRUITING
Conditions: Menopause
Interventions: DIETARY_SUPPLEMENT: Mixture of (Poly)phenols and a probiotic supplement|DIETARY_SUPPLEMENT: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of BLZ945 Single Agent or BLZ945 in Combination With PDR001 in Advanced Solid Tumors
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: DRUG: BLZ945|DRUG: PDR001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Behavioural Weight Loss Treatment for Patients With Atrial Fibrillation and Obesity in Cardiac Rehabilitation
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation|Obesity
Interventions: BEHAVIORAL: CR with added BWLT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tissue and Blood Samples From Patients With Low-Grade Glioma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: GENETIC: fluorescence in situ hybridization|GENETIC: loss of heterozygosity analysis|GENETIC: polymerase chain reaction|OTHER: flow cytometry|OTHER: immunohistochemistry staining method
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Drug-Drug Interaction Study Between Colchicine and Atorvastatin
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Colchicine|DRUG: Atorvastatin|DRUG: Colchicine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial Assessing Renal Damage During Ureteroscopy
Status: COMPLETED
Conditions: Nephrolithiasis
Interventions: DEVICE: Thulium Fibre Laser|DEVICE: Holmium:Yttrium-Aluminum-Garnet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of IDO Inhibitor in Combination With Checkpoint Inhibitors for Adult Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Metastatic Melanoma|Stage III Melanoma|Stage IV Melanoma
Interventions: DRUG: Indoximod|DRUG: Ipilimumab|DRUG: Nivolumab|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Ultrasound and Contrast Enhancement for Staging and Evaluation of Angiogenesis of Left Sided Colon Cancers
Status: COMPLETED
Conditions: Colonic Neoplasms
Interventions: DEVICE: Endoscopic ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Copper Cu 64 TP3805 PET in Detecting Prostate Cancer in Patients With Persistently Elevated PSA
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: RADIATION: Copper Cu 64 TP3805|PROCEDURE: Positron Emission Tomography and Computed Tomography Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Topical Piroxicam vs Soulagel in the Treatment of Acute Extremity Pain After Emergency Department Discharge
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: Soulagel®|DRUG: Arthrosyl®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes of the Trinica(R) Anterior Lumbar Plate: Fixed Screws vs. Variable Screws
Status: TERMINATED
Conditions: Degenerative Disc Disease|Spinal Stenosis|Spondylolisthesis
Interventions: DEVICE: Trinica Anterior Lumbar Plate System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Anticariogenic Effect of Silver Diamine Fluoride and Sodium Fluoride Varnish
Status: COMPLETED
Conditions: Early Childhood Caries
Interventions: DRUG: Silver diamine fluoride|DRUG: Sodium fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Self-management, Health Literacy and Social Capital in Socioeconomically Disadvantaged Older Adults
Status: COMPLETED
Conditions: Health Status Disparities|Subjective Health|Self Care|Social Capital|Health Literacy|Aging
Interventions: BEHAVIORAL: Program "Sentirnos bien" (Feeling well)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Pilot Study of an RCT to Improve Infection Management in Advanced Dementia
Status: COMPLETED
Conditions: Dementia
Interventions: BEHAVIORAL: Intervention|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Mycophenolate Mofetil Plus Steroid in the Treatment Of Patients With Progressive Idiopathic Membranous Nephropathy
Status: UNKNOWN
Conditions: Idiopathic Membranous Nephropathy
Interventions: DRUG: Mycophenolate Mofetil|DRUG: Cyclosporins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Study Effect of the Combination of Midodrine and Tolvaptan Versus Tolvaptan Alone in Patients With Severe Hyponatremia in Cirrhosis(TOLMINA Trial)
Status: UNKNOWN
Conditions: Liver Cirrhosis
Interventions: DRUG: Tolvaptan Tablets|DRUG: Midodrine Oral Tablet|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Single-Dose Levalbuterol Tartrate HFA MDI Vs Placebo in Subjects 18 Years and Older With EIB
Status: COMPLETED
Conditions: Exercise-induced Bronchospasm
Interventions: DRUG: Levalbuterol tartrate HFA MDI|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab With Maintenance Olaparib or Maintenance Pemetrexed in First-line (1L) Metastatic Non-squamous Non-Small-Cell Lung Cancer (NSCLC) (MK-7339-006, KEYLYNK-006)
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Non-squamous Non-small-cell Lung
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Pemetrexed|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Small Changes Behavioural Weight Loss Treatment Approach for Psoriatic Arthritis Patients With Comorbid Obesity
Status: COMPLETED
Conditions: Psoriatic Arthritis|Obesity
Interventions: BEHAVIORAL: BWLT|BEHAVIORAL: Waitlist Control for BWLT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Time Limited Eating in Adolescents (Time LEAd): a Pilot Study
Status: COMPLETED
Conditions: Obesity, Childhood
Interventions: BEHAVIORAL: Low sugar and carbohydrate diet|BEHAVIORAL: Time Limited Eating|DEVICE: Continuous Glucose Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasonographic Muscles and Fascia Measurement With Myofascial Pain Syndrome
Status: UNKNOWN
Conditions: Myofascial Pain Syndrome
Interventions: DEVICE: Ultrasonographic measurements of the trapezius and rhomboid muscle and fascia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Targeting Neuroinflammation as a Contributing Pathology in Alzheimer's Disease Dementia
Status: ENROLLING_BY_INVITATION
Conditions: Alzheimer Disease
Interventions: DRUG: C-11 ER-176|DIAGNOSTIC_TEST: Blood Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Prescription Lidocaine Patch to Over the Counter Lidocaine Patch and Placebo for Back Pain and Arthritis
Status: UNKNOWN
Conditions: Back Pain|Arthritis
Interventions: DRUG: lidocaine 5% patch|DRUG: lidocaine 3.6%, menthol 1.25%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy Using Temoporfin Before Surgery in Treating Patients With Recurrent Oral Cavity or Oropharyngeal Cancer
Status: WITHDRAWN
Conditions: Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity|Recurrent Squamous Cell Carcinoma of the Oropharynx|Recurrent Verrucous Carcinoma of the Oral Cavity|Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage I Squamous Cell Carcinoma of the Oropharynx|Stage I Verrucous Carcinoma of the Oral Cavity|Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage II Squamous Cell Carcinoma of the Oropharynx|Stage II Verrucous Carcinoma of the Oral Cavity|Tongue Cancer
Interventions: DRUG: photodynamic therapy|PROCEDURE: therapeutic conventional surgery|OTHER: laboratory biomarker analysis|DRUG: temoporfin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conditionally Increased Output (CIO) Enhanced Ultrasound System
Status: COMPLETED
Conditions: Nonalcoholic Fatty Liver|Nonalcoholic Steatohepatitis|Fatty Liver
Interventions: DEVICE: GE ultrasound system with increased acoustic output settings
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bioequivalence Study of Torrent Pharmaceuticals Ltd.'s Rosuvastatin Calcium Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Torrent's Rosuvastatin Calcium Tablets 40 mg|DRUG: Crestor 40 mg Tablets of AstraZeneca Pharmaceuticals LP, USA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CST-103 Co-administered With CST-107 in Subjects With Neurodegenerative Disorders
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild Cognitive Impairment, Lewy Body Dementia, Parkinson's Disease Rapid Eye Movement Sleep Behavior Disorder, Parkinson's Disease Dementia
Interventions: DRUG: CST-103, CST-107, matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of SB-497115-GR in Chronic Idiopathic Thrombocytopenic Purpura (ITP)
Status: COMPLETED
Conditions: Chronic Idiopathic Thrombocytopenic Purpura|Purpura, Thrombocytopenic, Idiopathic
Interventions: DRUG: SB-497115-GR 12.5mg|DRUG: SB-497115-GR 25mg|DRUG: SB-497115-GR 12.5mg matching placebo|DRUG: SB-497115-GR 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Economic Validation of the ISGPS Definition of PPAP
Status: COMPLETED
Conditions: Postoperative Acute Pancreatitis|Pancreaticoduodenectomy|Postoperative Pancreatic Fistula|Postoperative Complications
Interventions: DIAGNOSTIC_TEST: PPAP diagnosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Project CHOICE: Efficacy Testing of CHOICE and CHOICE+Normative Feedback Interventions
Status: COMPLETED
Conditions: Substance-related Disorders
Interventions: BEHAVIORAL: Motivational Interview with Normative Feedback|BEHAVIORAL: Motivational Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Freestyle Libre-based Education on MDI in T2DM (FreEdoM-2)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DEVICE: FreeStyle Libre 24 weeks|OTHER: SMBG (22 weeks) and blind CGM (2 weeks)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of NT 201 in the Treatment of Lateral Periorbital Wrinkles
Status: COMPLETED
Conditions: Lateral Periorbital Wrinkles
Interventions: DRUG: IncobotulinumtoxinA (Xeomin)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Programmed Intermittent Bolus Versus Continuous Infusion for Epidural Analgesia in Abdominal Surgery
Status: COMPLETED
Conditions: Analgesia, Epidural|Pain, Postoperative
Interventions: DEVICE: Programmed intermittent epidural bolus (PIEB) of bupicavaine|DEVICE: Continuous epidural infusion (CEI) of bupivacaine|DEVICE: Continuous epidural infusion (CEI) of morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Randomized, Open-label Economic and Medical Study on the Lymph Node Management of Squamous Cell Carcinoma of the Oral Cavity and Oropharynx Tumor Stage 1 or 2, Nodes 0 (T1-T2 N0) Operable
Status: COMPLETED
Conditions: Head and Neck Tumors
Interventions: OTHER: Surgery: GS strategy|OTHER: Surgery: Classic strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diphenoxylate / Atropine to Decrease FDG Activity During F-18 FDG PET
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Lomotil|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: High-frequency Alternating Current Stimulation for Tremor in Parkinson's Disease.
Status: RECRUITING
Conditions: Parkinson's Disease and Parkinsonism|Nerve Block|Motor Activity
Interventions: DEVICE: Active group 10kHz|DEVICE: Sham intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proton Beam Irradiation for the Treatment of Unresectable Hepatocellular Cancer or Hepatic Metastases
Status: COMPLETED
Conditions: Hepatocellular Cancer|Cholangiocarcinoma|Hepatic Metastases
Interventions: PROCEDURE: Proton Beam Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerability, Efficacy, and PK of ZSP1601 in Patients With Non-Alcoholic Steatohepatitis (NASH)
Status: COMPLETED
Conditions: Non-Alcoholic Steatohepatitis (NASH)
Interventions: DRUG: ZSP1601|DRUG: ZSP1601 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intensive Nutrition Training, Education, and Support in Gestational Diabetes - The INTENSE-GDM TRIAL
Status: RECRUITING
Conditions: GDM|Gestational Diabetes|Nutritional and Metabolic Diseases|Nutrition Therapy|Medical Nutrition Therapy
Interventions: BEHAVIORAL: Dietary treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Avastin in Patients With Epithelial Ovarian, Primary Peritoneal Serous or Fallopian Tube Cancer
Status: TERMINATED
Conditions: Ovarian Cancer|Primary Peritoneal Serous Cancer|Fallopian Tube Cancer
Interventions: DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BI 655066/ABBV-066 (Risankizumab) Compared to Active Comparator (Adalimumab) in Patients With Moderate to Severe Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: risankizumab|BIOLOGICAL: adalimumab|DRUG: placebo for risankizumab|BIOLOGICAL: placebo for adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Improved Oral Hygiene to Prevent Pneumonia in Hospitalized Patients
Status: COMPLETED
Conditions: Pneumonia
Interventions: DRUG: chlorhexidine gluconate oral rinse (0.12%)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Cytokine Clearance With Cytoabsorbant Device During Cardiac Bypass
Status: COMPLETED
Conditions: Myocardial Ischemia|Heart Valve Diseases
Interventions: DEVICE: Cytosorb
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: EBMtrialcentral- Comparing Initial Diuretic Therapies Using a Collaborative Network
Status: WITHDRAWN
Conditions: Hypertension
Interventions: DRUG: Chlorthalidone|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relationship Between the Posterior Atrial Wall and the Esophagus: Esophageal Position and Temperature MEasurement During Atrial Fibrillation Ablation.
Status: COMPLETED
Conditions: Atrial Arrhythmia
Interventions: PROCEDURE: Modification of the pulmonary vein ablation line|PROCEDURE: Regular PVI ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Self-Management Intervention for Patients Newly Diagnosed With Inflammatory Arthritis: The NISMA Trial
Status: NOT_YET_RECRUITING
Conditions: Inflammatory Arthritis
Interventions: BEHAVIORAL: Newly diagnosed with Inflammatory arthritis - a Self-MAnagement intervention (NISMA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fractionated Versus Target-controlled Propofol Administration in Bronchoscopy
Status: COMPLETED
Conditions: Lung Cancer|Sarcoidosis|Interstitial Pneumonia
Interventions: DEVICE: Flexible bronchoscopy in moderate sedation|DEVICE: Oxygen saturation|DEVICE: Blood pressure|DEVICE: Propofol dosage|DEVICE: Recovery time after bronchoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Randomized Study Comparing the Use of Epidural Analgesia to Intravenous Narcotics for Laparoscopic Colorectal Resection.
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: PROCEDURE: Epidural Analgesia|PROCEDURE: Parenteral Analgesia (Intravenous)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Muti-centered Investigation，Pathogenesis and Intervention Study of Non-suicidal Self-injury Behavior in China
Status: UNKNOWN
Conditions: NSSI
Interventions: OTHER: Dialectical behavior therapy|OTHER: Social support group therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Arsenic Trioxide and Itraconazole in Treating Patients With Advanced Basal Cell Cancer
Status: WITHDRAWN
Conditions: Skin Basal Cell Carcinoma
Interventions: DRUG: Arsenic Trioxide|DRUG: Itraconazole|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tetracycline Versus Doxycycline for HP Rescue Therapy
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Rabeprazole|DRUG: Bismuth potassium citrate|DRUG: Metronidazole|DRUG: Doxycycline|DRUG: Tetracycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Brain Stimulation in Vegetative State Patients
Status: COMPLETED
Conditions: Vegetative State|Minimally Conscious State
Interventions: DEVICE: Transcranial direct current stimulation (tDCS)|DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)|DEVICE: Transcranial Direct Current Stimulation (SHAM)|DEVICE: Repetitive Transcranial Magnetic Stimulation (SHAM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MabThera (Rituximab) in Patients With Idiopathic Thrombocytopenic Purpura.
Status: COMPLETED
Conditions: Idiopathic Thrombocytopenic Purpura
Interventions: DRUG: rituximab [MabThera/Rituxan]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Durvalumab Alone or With Tremelimumab in Refractory Germ Cell Tumors
Status: TERMINATED
Conditions: Germ Cell Tumor
Interventions: DRUG: Durvalumab|DRUG: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Secondary Prevention Trial for Ischemic Stroke With DengzhanShengmai Capsule
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: Dengzhan Shengmai capsule|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Masseter Myofascial Pain Relief Following an Intra-muscular Injection With Botulinum Toxin Type A.
Status: UNKNOWN
Conditions: Myalgia|Myofascial Pain
Interventions: DRUG: Botulinum toxin type A|OTHER: saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy of Levofloxacin 0.5% Ophthalmic Solution Administered Three Times a Day for Bacterial Conjunctivitis
Status: COMPLETED
Conditions: Bacterial Conjunctivitis
Interventions: DRUG: 0.5% levofloxacin eye drops|DRUG: 0.5% levofloxacin eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Atrial Fibrillation With Sinus Node Dysfunction: Intensive Device Follow-up
Status: UNKNOWN
Conditions: Sinus Node Dysfunction|Atrial Fibrillation
Interventions: OTHER: programing of pacemaker|PROCEDURE: AF ablation|DRUG: Anti arryhthmic drugs
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety of Red Yeast Rice for High Cholesterol in Individuals With Statin Intolerance
Status: COMPLETED
Conditions: Hypercholesterolemia|Statin-Associated Myopathy
Interventions: DIETARY_SUPPLEMENT: Red Yeast Rice|DRUG: Pravastatin|BEHAVIORAL: Lifestyle modification program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Tendon Injury Using Allogenic Adipose-derived Mesenchymal Stem Cells (Rotator Cuff Tear)
Status: COMPLETED
Conditions: Rotator Cuff Tear
Interventions: BIOLOGICAL: allogenic adipose stem cell injection|BIOLOGICAL: fibrin glue/normal saline injection|BIOLOGICAL: normal saline injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of a Synthetic Macromolecule (Hydroxypropyl Cellulose ) and Trehalose as Additives for Oocyte Vitrification
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: Synthetic macromolecule HPC and trehalose|PROCEDURE: SSS containing HSA and sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Effect of Meal Texture on Glucose-metabolism and Gut Hormone Response After Bariatric Surgery
Status: COMPLETED
Conditions: Glucose Metabolism Disorders|Obesity|Sleeve Gastrectomy|Gastric Bypass|Gut Hormones
Interventions: OTHER: Liquid meal|OTHER: Solid meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PSMA PET Imaging of Recurrent Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Adenocarcinoma|Prostate Cancer
Interventions: DRUG: Ga-HBED-iPSMA PET|DIAGNOSTIC_TEST: PET/CT|DIAGNOSTIC_TEST: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dual Therapy With Dabigatran/Ticagrelor Versus Dual Therapy With Dabigatran/Clopidogrel in ACS Patients With Indication for NOAC Undergoing PCI
Status: UNKNOWN
Conditions: Coronary Artery Disease|Myocardial Ischemia|Myocardial Infarction|Atrial Fibrillation
Interventions: DRUG: Dabigatran + Ticagrelor|DRUG: Dabigatran + clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT