pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of TJ003234 (Anti-GM-CSF Monoclonal Antibody) in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Adult Subjects
Interventions: DRUG: TJ003234|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Placebo-Controlled Study to Assess the Safety and Efficacy of ESK-001 in Active Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: SLE
Interventions: DRUG: ESK-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Rilematovir in Infants and Children and Subsequently in Neonates Hospitalized With Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus (RSV)
Status: TERMINATED
Conditions: Respiratory Tract Infections
Interventions: DRUG: Rilematovir|DRUG: Rilematovir X mg/kg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Investigate the Anti-oxidant Activity of Heptex in Patients With Apparent Risk Factors of NASH
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis
Interventions: DRUG: Heptex|OTHER: Rice bran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SEGWAY(Short-term Embolization Using Gelatin Particles for floW modulAtion During Y90 Radioembolization)
Status: RECRUITING
Conditions: Liver Cancer (Primary and Metastatic)
Interventions: DEVICE: NexGel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Mobile Devices and the Internet to Streamline an Asthma Clinical Trial
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: fluticasone/salmeterol 250/50 Dry Powder Inhaler|DRUG: fluticasone/salmeterol 100/50 Dry Powder Inhaler|DRUG: fluticasone 100mcg Dry Powder Inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety Study of a Modified SOX Regimen in First-Line Treatment of Unresectable Gastric Adenocarcinoma
Status: UNKNOWN
Conditions: Gastric Adenocarcinoma
Interventions: DRUG: S-1 and Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Three Part Study of MGV354 in Ocular Hypertension or Glaucoma
Status: COMPLETED
Conditions: Ocular Hypertension|Open-Angle Glaucoma
Interventions: DRUG: MGV354 ophthalmic suspension|DRUG: MGV354 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Promotion of Active Lifestyle in Pneumonia Patients
Status: NOT_YET_RECRUITING
Conditions: Pneumonia
Interventions: OTHER: Physical Activity Promotion|OTHER: Control Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HIGH AND LOW INTENSITY PROGRESSIVE RESISTED EXERCISES ON PAIN, RANGE OF MOTION AND FUNCTIONAL DISABILITY
Status: UNKNOWN
Conditions: Osteo Arthritis Knee|Sarcopenia
Interventions: OTHER: HIGH INTENSITY PROGRESSIVE RESISTED EXERCISE|OTHER: LOW INTENSITY PROGRESSIVE RESISTED EXERCISE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Brain Shift Calculation Study
Status: RECRUITING
Conditions: Tumor, Brain|Cavernoma|Arteriovenous Malformations|Intracerebral Hematoma
Interventions: DEVICE: Navigation-guided surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BIBW 2992 (Afatinib) for the Treatment of Patients With HER2-positive, Hormone-refractory Prostate Cancer
Status: TERMINATED
Conditions: Refractory Cancer
Interventions: DRUG: BIBW 2992 (Afatinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UltraSound Evaluation of Fluid tOleRanCE for Acute Kidney Injury
Status: NOT_YET_RECRUITING
Conditions: Acute Kidney Injury
Interventions: DIAGNOSTIC_TEST: Ultrasound evaluation of fluid tolerance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Averting Complications of Proton Pump Inhibitor Therapy by Effervescent Calcium Magnesium Citrate
Status: TERMINATED
Conditions: Osteoporosis|Hypomagnesemia
Interventions: DRUG: EffCaMgCit|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ph 1B Trial With ADI-PEG 20 Plus Nab-Paclitaxel and Gemcitabine in Subjects With Pancreatic Cancer
Status: COMPLETED
Conditions: Advanced Pancreatic Cancer
Interventions: DRUG: ADI-PEG 20
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Treprostinil in Subjects With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction
Status: TERMINATED
Conditions: Pulmonary Hypertension|Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: Oral treprostinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HSK7653 in Chinese Patients With Impaired Glucose Tolerance
Status: UNKNOWN
Conditions: Impaired Glucose Tolerance
Interventions: DRUG: HSK7653 10mg Q2W|DRUG: HSK7653 25mg Q2W|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a Dengue Vaccine (V180) in Healthy Adults (V180-001)
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: Low-dose V180 with low-dose ISCOMATRIX™ adjuvant|BIOLOGICAL: Low-dose V180 with medium-dose ISCOMATRIX™ adjuvant|BIOLOGICAL: Medium-dose V180 (non-adjuvanted)|BIOLOGICAL: Medium-dose V180 with low-dose ISCOMATRIX™ adjuvant|BIOLOGICAL: Medium-dose V180 with medium-dose ISCOMATRIX™ adjuvant|BIOLOGICAL: Medium-dose V180 with Alhydrogel™ adjuvant|BIOLOGICAL: High-dose V180 (non-adjuvanted)|BIOLOGICAL: High-dose V180 with low-dose ISCOMATRIX™ adjuvant|BIOLOGICAL: High-dose V180 with medium-dose ISCOMATRIX™ adjuvant|BIOLOGICAL: Low-dose V180 with high-dose ISCOMATRIX™ adjuvant|BIOLOGICAL: Medium-dose V180 with high-dose ISCOMATRIX™ adjuvant|BIOLOGICAL: High-dose V180 with high-dose ISCOMATRIX™ adjuvant|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of a Mental Health Curriculum for High School Students on Knowledge and Stigma
Status: COMPLETED
Conditions: Mental Disorders|Education Curriculum|Comparative Effectiveness Research|Early Intervention|Adolescents
Interventions: BEHAVIORAL: Curriculum|BEHAVIORAL: eLearning Follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Cognitive Behavioral Effects on Sleep, Pain, and Cytokines in Gynecologic Cancer
Status: COMPLETED
Conditions: Genital Neoplasms, Female|Insomnia|Pain|Adaptation, Psychological
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CONVERGE Post-Approval Study (PAS)
Status: RECRUITING
Conditions: Chronic Atrial Fibrillation
Interventions: DEVICE: Epicardial And Endocardial RF Ablation For The Treatment Of Symptomatic Long-standing Persistent AF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Rabbit Antithymocyte Globulin 3mg/kg in Kidney Transplant Patients Under Steroid-free and CNI Minimization Maintenance Immunosuppressive Regimen
Status: UNKNOWN
Conditions: Thymoglobulin Dose
Interventions: DRUG: Thymoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Digital Self-Management Program on A1C for Individuals With Type 2 Diabetes
Status: TERMINATED
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Online Diabetes Self-Management Education and Support (DSMES) Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Gutamine Administration in the Innate Immune System Response in ICU Patients.
Status: COMPLETED
Conditions: Moderate to Severe Trauma, as Defined by an|Injury Severity Score (ISS) > 12 Points Were Included in the Study.
Interventions: DIETARY_SUPPLEMENT: Total Parenteral Nutrition with Glutamine|OTHER: Total Parenteral Nutrition without glutamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Re-irradiation of High Grade Gliomas: a Quality of Life Study
Status: WITHDRAWN
Conditions: Anaplastic Astrocytoma|Glioblastoma Multiforme|Anaplastic Oligoastrocytoma
Interventions: OTHER: EORTC QLQ-C30|OTHER: EORTC QLQ-BN20|OTHER: Hopkins Verbal Learning Test-Revised (HVLT-R)|OTHER: Stroop color-word test|OTHER: Controlled oral word association test (COWA)|OTHER: Jamar hand dynamometer|OTHER: EORTC QLQ- FA13|OTHER: Trail Making Test (TMT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness Assessment of Vaccinating Schoolchildren Against Influenza
Status: COMPLETED
Conditions: Influenza|Acute Respiratory Infection
Interventions: BIOLOGICAL: Influenza vaccine|BIOLOGICAL: Control vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clofarabine, Cytarabine, and Filgrastim in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia, Advanced Myelodysplastic Syndrome, and/or Advanced Myeloproliferative Neoplasm
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndromes|Refractory Anemia With Excess Blasts|Untreated Adult Acute Myeloid Leukemia|Myeloproliferative Neoplasm With 10% Blasts or Higher
Interventions: BIOLOGICAL: filgrastim|DRUG: clofarabine|DRUG: cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IntravasCular Imaging-Guided Versus AngiogRaphy-GUided Drug-Eluting Stent Implantation for Fermoropopliteal Artery Disease
Status: RECRUITING
Conditions: Femoropopliteal Disease
Interventions: DEVICE: intravascular ultrasound-guided group|DEVICE: angiography-guided group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Persistent or Platinum Refractory Stage III or IV Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: endocrine-modulating drug therapy|DRUG: melphalan|DRUG: mitoxantrone hydrochloride|DRUG: tamoxifen citrate|DRUG: thiotepa|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Nintedanib for the Treatment of SARS-Cov-2 Induced Pulmonary Fibrosis
Status: RECRUITING
Conditions: SARS-Cov-2 Induced Pulmonary Fibrosis
Interventions: DRUG: Nintedanib 150 MG [Ofev]|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Decompression and Fusion Versus Open for Degenerative Lumbar Stenosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Lumbar Spinal Stenosis|Intervertebral Disc Degeneration
Interventions: PROCEDURE: lumbar fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Diclofenac Patch for Treatment of Acute Pain Due to Mild to Moderate Ankle Sprain
Status: COMPLETED
Conditions: Acute Pain|Ankle Sprain
Interventions: DRUG: Diclofenac Sodium|DRUG: Matching Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Drug-drug Interactions Between Masculinizing Hormone Therapy and Antiretroviral Agents Concomitantly for Pre-exposure Prophylaxis Among Transgender Men
Status: RECRUITING
Conditions: Drug Interaction
Interventions: DRUG: Emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg (F/TDF) and emtricitabine 200 mg/tenofovir alafenamide 25 mg (F/TAF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Use of Intracardiac Echocardiography or Left Atrial Appendage Radiography to Guide Implantation of a Left Atrial Appendage Occlusion Device.
Status: UNKNOWN
Conditions: Left Atrial Appendage Occlusion
Interventions: DEVICE: intracardiac echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Anodic Oxidation of Implant Abutment Collar on the Peri-implant Soft Tissue Health
Status: COMPLETED
Conditions: Dental Implants
Interventions: OTHER: Anodic oxidation|OTHER: Untreated abutment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Acute Periprosthetic Total Hip Arthroplasty Infections
Status: WITHDRAWN
Conditions: Periprosthetic Infection Total Hip Arthoplasty
Interventions: PROCEDURE: open debridement with modular exchange|PROCEDURE: one stage exchange
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Inhaled Molgramostim (rhGM-CSF) in Autoimmune Pulmonary Alveolar Proteinosis
Status: COMPLETED
Conditions: Autoimmune Pulmonary Alveolar Proteinosis
Interventions: DRUG: Molgramostim|DRUG: Placebo|DEVICE: PARI eFlow nebulizer system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vardenafil ODT (Orally Disintegrating Tablet) - Nifedipine Interaction Study
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Vardenafil ODT, (Staxyn, BAY38-9456)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: An Open-Label, Multicentre, Long-Term Extension Study of Etanercept in Ankylosing Spondylitis
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Phase IIIb, Open-label, Multi-center Study to Evaluate Safety, Tolerability and Efficacy of OAV101 Administered Intrathecally to Participants With SMA Who Discontinued Treatment With Nusinersen or Risdiplam
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Muscular Atrophy
Interventions: GENETIC: OAV101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of an Osteoarthritis (OA) Care Plan to Improve Process and Quality of OA Treatment Decisions
Status: COMPLETED
Conditions: Osteo Arthritis Knee|Osteoarthritis, Hip
Interventions: OTHER: OA Care Plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug-Drug Interaction Study Between Fenofibric Acid and Efavirenz
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: efavirenz|DRUG: fenofibric acid 105 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vildagliptin Compared to Gliclazide as Dual Therapy With Metformin in Muslim Patients With Type 2 Diabetes Fasting During Ramadan
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Vildagliptin|DRUG: Gliclazide|DRUG: Metformin|DRUG: Placebo to Gliclazide|DRUG: Placebo to Vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot RCT of Veraflo With Prontosan vs VAC in Wounds Requiring Operative Debridement
Status: COMPLETED
Conditions: Wounds and Injuries
Interventions: DEVICE: V.A.C.Ulta with Prontosan instillation|DEVICE: V.A.C.Ulta without instillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact on Quality of Life and Health of the CONTINUUM+ CONNECT Remote Monitoring Solution
Status: RECRUITING
Conditions: Prostatic Neoplasms|Lung Neoplasms|Breast Neoplasms|Colorectal Neoplasms
Interventions: DEVICE: CONTINUUM+ CONNECT remote monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Coenzyme Q10 on Diabetic Children
Status: NOT_YET_RECRUITING
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Coenzyme Q10 Cap/Tab as natural factors capsules or kirkman tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Improving Genetic Counseling for BRCA+ Mothers
Status: RECRUITING
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Education and counseling|BEHAVIORAL: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of an Anti-inflammatory on Tooth Sensitivity Caused by Bleaching
Status: COMPLETED
Conditions: Color Changes During Tooth Formation
Interventions: DRUG: Etoricoxib|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant TIL- and Response-Adapted Chemoimmunotherapy for TNBC
Status: RECRUITING
Conditions: Triple Negative Breast Cancer|Breast Cancer
Interventions: DRUG: Carboplatin|DRUG: Docetaxel|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dronabinol in Total Knee Arthroplasty (TKA)
Status: COMPLETED
Conditions: Total Knee Arthroplasty|Opioid Use
Interventions: DRUG: Dronabinol 5mg Cap|OTHER: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PAINED: Project Addressing INequities in the Emergency Department
Status: RECRUITING
Conditions: Pain|Appendicitis|Bias, Racial|Fractures, Bone
Interventions: BEHAVIORAL: Department-level audit and feedback and electronic health record-embedded clinical decision support
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Role of Desloratadine in Reducing Inflammation From Occupational Heat Strain
Status: UNKNOWN
Conditions: Heat Stress, Exertional|Inflammatory Response|Firefighter Personal Protective Equipment
Interventions: DRUG: Desloratadine|DRUG: Placebo|OTHER: No Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Fiber-enriched Croissant Consumption and Effects on Metabolic Status, Appetite and Gut Microbiota
Status: COMPLETED
Conditions: Healthy|Overweight and Obesity
Interventions: OTHER: Fiber Croissant (FIBCRO) Group|OTHER: Control Croissant (CONCRO) Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Attention and Pain in Children With and Without Attention Deficit and/or Hyperactivity Disorder
Status: UNKNOWN
Conditions: Attention Deficit Disorder With Hyperactivity|Placebo Effect|Nocebo Effect|Pain
Interventions: BEHAVIORAL: Placebo and nocebo effect
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Patient-Specific Decision Aid System for Shared Decision Making About Breast Reconstruction
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Carcinoma
Interventions: OTHER: Enhanced Consultation|OTHER: Standard of Care Consultation|PROCEDURE: Conventional Imaging|OTHER: Educational Intervention|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Advanced Glycation Endproducts and Bone Material Strength in T2D Treated With Pyridoxamine
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DIETARY_SUPPLEMENT: Pyridoxamine Dihydrochloride|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Effectiveness and Adverse Events of JUVEDERM VOLBELLA With Lidocaine Injection in Correcting Infraorbital Hollowing in Chinese Adult Participants
Status: COMPLETED
Conditions: Infraorbital Hollowing
Interventions: DEVICE: VOLBELLA with Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone and Functional Outcome After TKA
Status: COMPLETED
Conditions: Chronic Knee Pain|Dexamethasone|Total Knee Arthroplasty
Interventions: DRUG: Dexamethasone|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Once-daily Dose Regimen of 7-day and 14-day High Dose Rabeprazole-levofloxacin Based Quadruple Therapy for H. Pylori Eradication in Thai Patients With Non-ulcer Dyspepsia
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DIAGNOSTIC_TEST: 13C Urea Breath Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: (SYMPHONY) Phase 1/2 Study Targeting EGFR Resistance Mechanisms in NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Neoplasms|Carcinoma, Non-Small-Cell Lung|Respiratory Tract Neoplasms|Neoplasms|Neoplasms by Site|Lung Diseases|Respiratory Tract Disease|Carcinoma, Bronchogenic|Bronchial Neoplasms|Adenocarcinoma|Carcinoma|Neoplasms by Histologic Type|Neoplasms, Nerve Tissue|EGFR T790M|EGFR C797S|EGFR L858R|EGFR Gene Mutation|EGF-R Positive Non-Small Cell Lung Cancer|EGFR Exon 19 Deletion|EGFR Mutation Resulting in Tyrosine Kinase Inhibitor Resistance|EGFR Activating Mutation|Protein Kinase Inhibitors|Antineoplastic Agents|Thoracic Neoplasms
Interventions: DRUG: BLU-945|DRUG: osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Clinical Trial of Recombinant COVID-19 Variant Vaccine (Sf9 Cell)
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Recombinant COVID-19 variant vaccine (Sf9 cell)|BIOLOGICAL: Recombinant COVID-19 vaccine (CHO cell)|BIOLOGICAL: Recombinant COVID-19 vaccine (Sf9 cell)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study
Status: RECRUITING
Conditions: Head and Neck Carcinoma|Head and Neck Carcinoma of Unknown Primary|Hypopharyngeal Carcinoma|Laryngeal Carcinoma|Metastatic Malignant Neoplasm in the Lymph Nodes|Nasal Cavity Carcinoma|Oral Cavity Carcinoma|Oropharyngeal Carcinoma|Paranasal Sinus Carcinoma|Salivary Gland Carcinoma|Cutaneous Squamous Cell Carcinoma of the Head and Neck|Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Cisplatin|PROCEDURE: Intensity-Modulated Proton Therapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|PROCEDURE: Biospecimen Collection|RADIATION: Intensity-Modulated Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Forearm-Supported Head Extension to Decrease Dental Contact
Status: UNKNOWN
Conditions: Endotracheal Intubation
Interventions: PROCEDURE: Laryngoscopy with forearm-support|PROCEDURE: Laryngoscopy without forearm-support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Research and Innovation to Stop E-cigarette/Vaping in Young Adults
Status: COMPLETED
Conditions: Nicotine Dependence|E-Cig Use
Interventions: DRUG: Nicotine patch|BEHAVIORAL: Phone Counseling|BEHAVIORAL: Digital Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Maternal Role Preparation and Awareness-Centred Occupational Therapy Trainings in Pregnant Women
Status: RECRUITING
Conditions: Pregnancy Related|Postpartum Complication
Interventions: OTHER: Maternal Role Preparation Training|OTHER: Awareness Centred Occupational Therapy Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Adalimumab in Adult Chinese Subjects With Active Ankylosing Spondylitis
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: BIOLOGICAL: adalimumab|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Online HD-tDCS Over the Left DLPFC During a Working Memory Task for Treating Negative Symptoms of Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia|Schizoaffective Disorder, Mixed Type|Negative Symptoms in Schizophrenia
Interventions: DEVICE: HD-tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Inhaled Pre-prandial Human Insulin in Type 2 Diabetes
Status: TERMINATED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: rosiglitazone|DRUG: inhaled human insulin|DRUG: glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy Before Surgery for Localized, Resectable Soft Tissue Sarcoma of the Extremity and Superficial Trunk
Status: ACTIVE_NOT_RECRUITING
Conditions: Resectable Soft Tissue Sarcoma|Stage I Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8|Stage IA Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8|Stage IB Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8|Stage II Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8
Interventions: RADIATION: Hypofractionated Radiation Therapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of G-CSF on MRD After Induction Therapy in Newly Diagnosed AML
Status: UNKNOWN
Conditions: Granulocyte Colony-stimulating Factor|Minimal Residual Disease|Acute Myeloid Leukemia
Interventions: DRUG: G-SCF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Prevention of Systemic Ectopic Mineralization in Pseudoxanthoma Elasticum
Status: RECRUITING
Conditions: Pseudoxanthoma Elasticum
Interventions: DRUG: Etidronate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hematopoietic Cell Transplantation With Post-transplantation Cyclophosphamide in MDS
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Ibrutinib & Obinutuzumab With/Without CHOP for Richter's Transformation or Richter's Syndrome Patients
Status: TERMINATED
Conditions: Richter Syndrome
Interventions: DRUG: Obinutuzumab|DRUG: Ibrutinib|OTHER: CHOP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sporebiotics in FD
Status: COMPLETED
Conditions: Dyspepsia|Dysbiosis
Interventions: DIETARY_SUPPLEMENT: spore-forming probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Grapefruit on QT Interval in Healthy Volunteers and Patients With Congenital Long QT Syndrome
Status: COMPLETED
Conditions: Long QT Syndrome
Interventions: DRUG: Moxifloxacin|DIETARY_SUPPLEMENT: Grapefruit group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Talabostat and Docetaxel in Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: talabostat (PT-100) tablets|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polyphenols and Overfeeding
Status: COMPLETED
Conditions: Overfeeding
Interventions: DIETARY_SUPPLEMENT: 2g of grape polyphenol extract|DIETARY_SUPPLEMENT: Dietary Supplement: 2g of placebo (lactose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bioavailability of Orally Ingested Vitamin C
Status: WITHDRAWN
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Phosphatidylcholine-lipid encapsulated vitamin C|DIETARY_SUPPLEMENT: Crystalline vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Histidine-Tryptophane-Ketoglutarate (HTK) vs University of Wisconsin (UW) Perfusion in Clinical Pancreas Transplantation
Status: COMPLETED
Conditions: Diabetes Mellitus|Pancreas Transplantation
Interventions: OTHER: Organ perfusion during pancreas procurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retrain Your Brain in Children/Adolescents With Bipolar Disorder: A Pilot Study
Status: UNKNOWN
Conditions: Bipolar Disorder|Pediatric Bipolar Disorder|Childhood-onset Bipolar Disorder
Interventions: BEHAVIORAL: COGFLEX-skill building levels|BEHAVIORAL: COGFLEX-control condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multimodality MRI and Liquid Biopsy in GBM
Status: WITHDRAWN
Conditions: Glioblastoma Multiforme|Brain Tumor, Adult: Glioblastoma|Brain Tumor, Recurrent|Brain Tumor, Primary
Interventions: DIAGNOSTIC_TEST: Post Feraheme Infusion MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Improving Symptoms of Schizophrenia and Schizoaffective Disorder by Supplementing Medications With Pravastatin
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Pravastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Mobile Self-Management of Irritable Bowel Syndrome for Adolescents
Status: COMPLETED
Conditions: Irritable Bowel Syndrome|Abdominal Pain
Interventions: BEHAVIORAL: BodiMojo Buddy for IBS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Streptococcus Salivarius K12@Lip@GSH Alleviates Oral Mucositis in Patients Undergoing Radiotherapy
Status: COMPLETED
Conditions: Oral Mucositis
Interventions: DIETARY_SUPPLEMENT: SsK12@Lip@GSH
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Relationship Between Relaxation or Wheat Germ Juice to the Immune Indices and Quality of Life (QoL) in Colorectal Cancer Patients on Adjuvant Chemotherapy
Status: UNKNOWN
Conditions: Colon Cancer
Interventions: BEHAVIORAL: biofeedback|DRUG: Wheatgerm juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Combination Study of Rucaparib and Atezolizumab in Participants With Advanced Gynecologic Cancers and Triple-Negative Breast Cancer
Status: COMPLETED
Conditions: Gynecologic Neoplasms
Interventions: DRUG: Atezolizumab|DRUG: Rucaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Physical Activity Program on Sedentary of Patients With Upper Aerodigestive Tract Cancer
Status: NOT_YET_RECRUITING
Conditions: Upper Aerodigestive Tract Cancer|Head and Neck Cancer
Interventions: BEHAVIORAL: behavioral|OTHER: Sedentary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tranexamic Acid in Breast Esthetic Surgery.
Status: RECRUITING
Conditions: Hemorrhage|Bleeding
Interventions: DRUG: Placebo|DRUG: Tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Clinical Investigation of the Vanguard 360 Revision Knee
Status: RECRUITING
Conditions: Osteoarthritis|Rheumatoid Arthritis|Traumatic Arthritis|Post Traumatic Deformity|Complications; Arthroplasty|Deformity of Limb
Interventions: DEVICE: Vanguard SSK 360 with PS Bearing|DEVICE: Vanguard SSK 360 with PSC bearing|DEVICE: Vanguard DA 360|DEVICE: Vanguard 360 TiNbN Femur with PS bearing|DEVICE: Vanguard 360 TiNbN Femur with PSC bearing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Territorial Implementation and Evaluation of a Multiple Sclerosis Expert Patient Program
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis|Quality of Life|Patient Empowerment|Patient Activation|Fatigue|Peer Group
Interventions: OTHER: Multiple Sclerosis Expert Patient Program of Catalonia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mechanistic Studies of B- and T-Cell Function in RA Patients Treated With TNF Antagonists, Tocilizumab, or Abatacept
Status: TERMINATED
Conditions: Rheumatoid Arthritis (RA)
Interventions: DRUG: TNF Antagonist (enbrel, humire, remicade, cimzia, symponi)|DRUG: Abatacept|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Protease Inhibitor Monotherapy Versus Ongoing Triple-therapy in the Long Term Management of HIV Infection (PIVOT)
Status: UNKNOWN
Conditions: HIV Infection|Acquired Immunodeficiency Syndrome
Interventions: DRUG: Protease Inhibitor|DRUG: Standard-of-care Antiretroviral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tazarotene Gel in Nail Psoriasis
Status: COMPLETED
Conditions: Nail Psoriasis
Interventions: DRUG: Experimental Tazarotene Gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ATG in Haploidentical HSCT for Acute Graft-versus-host Disease Prophylaxis
Status: COMPLETED
Conditions: Hematopoietic Stem Cell Transplantation|Antithymocyte Globulin|Viral Infection
Interventions: DRUG: ATG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety and Efficacy Study and Dose-Escalation Substudy of PF 06838435 in Individuals With Hemophilia B
Status: ACTIVE_NOT_RECRUITING
Conditions: Hemophilia B
Interventions: BIOLOGICAL: PF-06838435 (formerly SPK-9001)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Care After Discharge of HF Patients
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: Natriuretic peptides levels to J7 and J14|OTHER: Consultations specialized to J7 and J14|OTHER: Phone calls in 6 months and 12 months|OTHER: Natriuretic peptides levels at 6 months|OTHER: Consultation with the general doctor or the cardiologist to J30 with blood results
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Late Surfactant for Prevention of Bronchopulmonary Dysplasia
Status: COMPLETED
Conditions: Bronchopulmonary Dysplasia
Interventions: DRUG: Infasurf surfactant (ONY, Inc.)|DRUG: Sham (No Treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Therapeutic Literacy Evaluation in Liver Transplanted Patients
Status: COMPLETED
Conditions: Health Literacy|Liver Transplantation
Interventions: OTHER: HLQ (Health literacy questionnaire)|OTHER: MoCA (Montreal Cognitive Assessment)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Histidine-Tryptophan-Ketoglutarate Solution Versus Blood Cardioplegia in CABG
Status: COMPLETED
Conditions: Cardioplegia Solution Adverse Reaction
Interventions: DRUG: HTK cardioplegic solution|DRUG: blood cardioplegia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SNaP Wound Care System Versus Traditional NPWT Device for Treatment of Chronic Wounds
Status: COMPLETED
Conditions: Ulcers|Wounds
Interventions: DEVICE: Traditional NPWT System|DEVICE: SNaP Wound Care System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma
Status: RECRUITING
Conditions: Large B-Cell Lymphoma
Interventions: DRUG: Glofitamab|DRUG: Polatuzumab vedotin|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SurVaxM Plus Adjuvant Temozolomide for Newly Diagnosed Glioblastoma (SURVIVE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Newly Diagnosed Glioblastoma
Interventions: BIOLOGICAL: SurVaxM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy for Insomnia for Gulf War Illness
Status: COMPLETED
Conditions: Gulf War Illness|Insomnia
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia (CBTi)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Stimulation|Failed Back Surgery Syndrome|Genetic Change
Interventions: DEVICE: Implanted pulse generator for SCS with different programming modalities
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Treatment Outcomes Between Convergent Procedure and Catheter Ablation for Persistent and Longstanding Persistent Atrial Fibrillation
Status: WITHDRAWN
Conditions: Persistent Atrial Fibrillation|Longstanding Persistent Atrial Fibrillation
Interventions: PROCEDURE: Catheter ablation|PROCEDURE: Convergent procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Cost Effectiveness of Alpha-Stim AID CES
Status: COMPLETED
Conditions: Anxiety
Interventions: DEVICE: Alpha Stim AID cranial electrotherapy stimulation|BEHAVIORAL: Pregnancy test|OTHER: Anxiety questionnaire|OTHER: Quality of life questionnaire|OTHER: Work and social questionnaire|OTHER: Sleep questionnaire|OTHER: Depression questionnaire|OTHER: Quality of life and financial questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dosing Study of Amino Acids in Seriously Ill Patients
Status: TERMINATED
Conditions: Parenteral Nutrition (No Primary Condition Studied)
Interventions: DRUG: 15% CLINISOL - Sulfite-free (Amino Acid) Injection|DRUG: 15% CLINISOL - Sulfite-free (Amino Acid) Injection|DRUG: 15% CLINISOL - Sulfite-free (Amino Acid) Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Exploratory Clinical Study on a Variable Speed and Sensing Treadmill System (VASST) for Hemiparetic Gait Rehabilitation
Status: COMPLETED
Conditions: Stroke|Hemiplegic Gait
Interventions: DEVICE: Variable Speed and Sensing Treadmill
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Methylene Blue Combined With Artesunate or Amodiaquine for Malaria Treatment in Children of Burkina Faso: a Pilot Study
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Methylene blue|DRUG: Artesunate|DRUG: Amodiaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PIEB Compared With CEI on Breakthrough Pain in Nulliparous Women
Status: NOT_YET_RECRUITING
Conditions: Breakthrough Pain
Interventions: DRUG: programmed intermittent Bolus epidural analgesia|DRUG: continuous epidural infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Brentuximab Vedotin in Treating Patients With Steroid-Resistant Acute Graft-Versus-Host Disease
Status: WITHDRAWN
Conditions: Graft Versus Host Disease
Interventions: DRUG: brentuximab vedotin|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Bolus Dose of Dexmedetomidine (ED50) That Avoids Hemodynamic Compromise in Children
Status: COMPLETED
Conditions: Hemodynamic Instability
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of Kylo-0603 in Healthy Subjects
Status: RECRUITING
Conditions: Nonalcoholic Steatohepatitis
Interventions: DRUG: Kylo-0603 capsule|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT