pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pilot, Neoadjuvant Gemcitabine and Abraxane Chemotherapy Followed by Surgery, Adenocarcinoma of the Pancreas
Status: TERMINATED
Conditions: Adenocarcinoma Pancreas
Interventions: PROCEDURE: Surgery|GENETIC: Genetic Expression|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Analgesic Efficacy And Safety Of Tanezumab Alone Or In Combination With Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Versus NSAIDs Alone In Patients With Osteoarthritis Of The Knee Or Hip
Status: TERMINATED
Conditions: Osteoarthritis|Arthritis
Interventions: DRUG: NSAID|BIOLOGICAL: tanezumab|BIOLOGICAL: tanezumab|BIOLOGICAL: tanezumab|DRUG: NSAID|BIOLOGICAL: tanezumab|DRUG: NSAID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on Prevention Strategies for CKD-SHPT and Related Complications Based on General Vitamin D Supplementation
Status: RECRUITING
Conditions: Chronic Kidney Disease 5D|Secondary Hyperparathyroidism Due to Renal Causes|Vitamin D Deficiency
Interventions: DRUG: High-dose vitamin D2 softgels|DRUG: low-dose vitamin D2 softgels|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Identification of New Biomarkers of Insulin Resistance
Status: ACTIVE_NOT_RECRUITING
Conditions: Insulin Resistance|Diabetes Mellitus, Type 2|Inflammation|Gastrointestinal Microbiome
Interventions: BEHAVIORAL: Controlled diet and exercise.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of Implanting the Biotronik Passeo-18 Lux Drug Coated Balloon to Treat Failing Haemodialysis Arteriovenous Fistulas and Grafts.
Status: UNKNOWN
Conditions: Arterio-venous Fistula|Dialysis Access Malfunction|Hemodialysis Access Failure|Arteriovenous Graft Stenosis
Interventions: DEVICE: Passeo-18 Lux
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Capecitabine (Xeloda) in Participants With Advanced or Metastatic Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: 5-Fluorouracil|DRUG: Capecitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improvement Effect of Lacosamide and Levetiracetam on Cognitive in Alzheimer's Disease Patients With Epilepsy
Status: RECRUITING
Conditions: Alzheimer Disease 3|Epilepsy
Interventions: DRUG: Lacosamide 100 mg|DRUG: Levetiracetam 250mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of One Morphine Sulfate Sustained-Release 200 mg Capsule With Two 100 mg KADIAN Capsules on Applesauce
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: morphine sulfate sustained-release capsules|DRUG: KADIAN (morphine sulfate sustained-release) capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Acceptability and Nutritional Impact of Double-fortified Salt Containing Iodine and Folic Acid
Status: ACTIVE_NOT_RECRUITING
Conditions: Folate Deficiency|Iodine Deficiency|Anemia Macrocytic|Anemia Deficiency|Salt Intake|Vitamin B 12 Deficiency
Interventions: DIETARY_SUPPLEMENT: Iodized salt|DIETARY_SUPPLEMENT: Experimental: Iodized salt with lower-dose folic acid fortification|DIETARY_SUPPLEMENT: Experimental: Iodized salt with higher-dose folic acid fortification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Adding Dexmedetomidine as an Adjuvant to Bupivacaine in TAP Block and Caudal Block
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Building Resiliency and Vital Equity (BRAVE) Project: Understanding Native Americans' Perceptions/Beliefs About COVID-19 Testing and Vaccination Study
Status: UNKNOWN
Conditions: Covid19 Virus Infection
Interventions: BEHAVIORAL: Protect Your Elders Campaign
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: iPACES v3 MCI NIA Protocol Copied for iPACES v4 PD NINDS
Status: NOT_YET_RECRUITING
Conditions: Parkinson's Disease|PD|Mild Cognitive Impairment|MCI
Interventions: DEVICE: iPACES (interactive Physical and Cognitive Exercise System)|DEVICE: PACE (Physical and Cognitive Exercise)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cottonseed Oil Dose Response
Status: RECRUITING
Conditions: Dyslipidemias|Overweight and Obesity|Nutrition, Healthy
Interventions: OTHER: CSO LOW|OTHER: CSO MID|OTHER: CSO HIGH|OTHER: CONTROL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Adjustable Gastric Banding and Its Effects on Postprandial Glucose Metabolism Independent of Weight Loss
Status: COMPLETED
Conditions: Obesity|Diabetes
Interventions: PROCEDURE: Adjustable gastric banding|BEHAVIORAL: Dietary and lifestyle modification
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Secondhand Smoke Exposure Reduction Among Young Children in China
Status: COMPLETED
Conditions: Secondhand Smoke Exposure|Respiratory Illness|Smoking Cessation
Interventions: BEHAVIORAL: SHI counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PFO Closure, Oral Anticoagulants or Antiplatelet Therapy After PFO-associated Stroke in Patients Aged 60 to 80 Years
Status: NOT_YET_RECRUITING
Conditions: Cryptogenic Ischemic Stroke|Patent Foramen Ovale
Interventions: PROCEDURE: Transcatheter PFO closure|DRUG: Oral Anticoagulant, Direct-Acting|DRUG: Antiplatelet therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transcranial Direct Current Stimulation for Depression
Status: RECRUITING
Conditions: Depressive Disorder
Interventions: DEVICE: Active Transcranial direct current stimulation|DEVICE: Sham Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Characterization of Nicotine Exposure and Urge-to-Smoke Following Use of Electronic and Conventional Cigarettes
Status: COMPLETED
Conditions: Smoking
Interventions: OTHER: blu™ Classic Tobacco rechargeable (2.4% nicotine, glycerin vehicle)|OTHER: blu™ Classic Tobacco rechargeable (2.4% nicotine, glycerin/PG vehicle)|OTHER: blu™ Magnificent Menthol rechargeable (2.4% nicotine, glycerin vehicle)|OTHER: blu™ Classic Tobacco rechargeable (1.6% nicotine, glycerin vehicle)|OTHER: blu™ Classic Tobacco rechargeable (1.6% nicotine, glycerin/PG vehicle)|OTHER: Marlboro Cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Continuous Stitches Versus Simple Interrupted Stitches for Anterior Colporrhaphy
Status: UNKNOWN
Conditions: Cystocele|Cystocele, Midline|Vaginal Prolapse|Prolaps Bladder|Pelvic Organ Prolapse
Interventions: PROCEDURE: Anterior colporrhaphy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Re-Connect Application for Smoking Cessation
Status: RECRUITING
Conditions: Smoking Cessation|Acceptability of Health Care|Nicotine Dependence, Cigarettes
Interventions: BEHAVIORAL: Abstinent Contingent (AC) Re-Connect|BEHAVIORAL: Submission Contingent (SC) Re-Connect
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study of TransCon TLR7/8 Agonist With or Without Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Locally Advanced Solid Tumor|Metastatic Solid Tumor|Head and Neck Squamous Cell Carcinoma HNSCC|HPV-associated Cancers|Neoadjuvant Melanoma|Neoadjuvant Cutaneous Squamous Cell Carcinoma (cSCC)
Interventions: DRUG: TransCon TLR7/8 Agonist|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Sirolimus in Subjects With Metastatic, Mismatch Repair Deficient Solid Tumors After Immunotherapy
Status: TERMINATED
Conditions: Metastatic dMMR Solid Cancer|Solid Tumor|Cancer|Metastatic Solid Tumor
Interventions: DRUG: Sirolimus 2mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: School-Based Assessment of Micronutrient Interventions in Adolescents (SAMIA) in Zanzibar
Status: COMPLETED
Conditions: Anemia
Interventions: DIETARY_SUPPLEMENT: Iron and folic acid (IFA)|DIETARY_SUPPLEMENT: Multiple Micronutrient Supplement (MMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparative Study of Three NNRTI-Sparing HAART Regimens
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: Emtricitabine/tenofovir disoproxil fumarate|DRUG: Raltegravir|DRUG: Darunavir|DRUG: Ritonavir|DRUG: Atazanavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Perioperative Heated Sock Use in Preventing Hypothermia During Total Hip Prosthesis Surgery
Status: COMPLETED
Conditions: Hip Fractures|Hip Injuries
Interventions: OTHER: WARM SOCKS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Estimation of Minimum Efficacy Daily Dose of Jarlsberg Cheese
Status: COMPLETED
Conditions: Heathy Women|Pre Menopausal Age|Exlution Criteria: Gastrointestinal Disorder|Liver Disease|Diabetes|Cancer|Kidney Disorder
Interventions: DIETARY_SUPPLEMENT: Jarlsberg cheese
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Optimal Timing for Laparoscopic Cholecystectomy After Cholecystostomy in Acute Cholecystitis Tokyo II/III Setting
Status: RECRUITING
Conditions: Cholecystitis, Acute
Interventions: PROCEDURE: Optimal timing for laparoscopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Executive Dysfunction in Restless Legs Syndrome: Clinical Correlates and Outcome After Therapeutic Management
Status: RECRUITING
Conditions: Restless Legs Syndrome
Interventions: OTHER: Polysomnography|OTHER: Clinical Scales|OTHER: Assessment of executive functions|OTHER: Medical consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: What is the Prevalence of Methicillin-Resistant Staphylococcus Aureus in Skin and Soft Tissue Infections Presenting to the Emergency Departments of a Canadian Academic Health Care Center?
Status: COMPLETED
Conditions: Bacterial Infections|Gram-Positive Bacterial Infections|Staphylococcal Infections
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevention of Photoparoxysmal Abnormalities by Mozart K448
Status: TERMINATED
Conditions: Photoparoxysmal Abnormalities|Epilepsy|Seizures
Interventions: OTHER: Mozart K448|OTHER: Beethoven's Für Elise|OTHER: No music exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Novel Strategies to Improve Cardiometabolic Status and Adherence to Exercise Regimens in Patients at High Risk for Cardiovascular Disease
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Myocardial Infarction|Coronary Artery Disease|Atrial Fibrillation|Congestive Heart Failure
Interventions: BEHAVIORAL: BURST physical activity|BEHAVIORAL: Text Message Reminders|BEHAVIORAL: Moderate Intensity Continuous Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Omeprazole and Ritonavir on GSK2336805 Pharmacokinetics in Healthy Adults
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Cohort 1 (GSK2336805 60mg x 1 dose, Omeprazole 40 mg q24h x 4 days, GSK2336805 60 mg x 1 dose and Omeprazole 40 mg x 1 dose)|DRUG: Cohort 2 (GSK2336805 30mg x 1 dose, Ritonavir 100mg q12h x 4 days, and Ritonavir 100mg q12h x 1 dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety, Tolerability, and Pharmacokinetics of Inhaled TLC19 in Healthy Volunteers
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: TLC19|DRUG: TLC19 Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of CDP870 and Methotrexate Compared to Methotrexate Alone in Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: CDP870
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Pamiparib and Low Dose Temozolomide In Patients With Platinum Sensitive Biliary Tract Cancer
Status: WITHDRAWN
Conditions: Platinum-Sensitive Biliary Tract Cancer
Interventions: DRUG: Cisplatin|DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Pamiparib|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Neoadjuvant Chemotherapy With Atezolizumab or Placebo in Patients With Triple-Negative Breast Cancer Followed After Surgery by Atezolizumab or Placebo
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Placebo|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multifaceted Prompting Intervention for Urban Children With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Multifaceted Prompting Intervention MPI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Adjuvant PD-1 Inhibitor for Patients With Early-stage Hepatocellular Carcinoma Following Microwave Ablation
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: PD-1 Inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Subjects to Evaluate Bioavailability of 4 Formulations of E5501
Status: COMPLETED
Conditions: Idiopathic Thrombocytopenic Purpura
Interventions: DRUG: 10-mg dose of E5501 2G tablet|DRUG: 10-mg dose of E5501 cyclodextrin oral solution|DRUG: 10-mg dose of E5501-P21% powder|DRUG: 10-mg dose of E5501 lipid-based oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Comparison of Airway Sealing With the Laryngeal Mask Airway (LMA) Supreme at Different Intracuff Pressure in Children
Status: COMPLETED
Conditions: General Anesthesia
Interventions: PROCEDURE: intracuff pressure by cuff pressure manometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose:
Clinical trial: Regadenoson Stress-MRI to Identify Coronary Artery Disease in Atrial Fibrillation Patients
Status: COMPLETED
Conditions: Atrial Fibrillation|Coronary Artery Disease
Interventions: DRUG: Regadenoson MRI|DRUG: Gadobenate dimeglumine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I Study to Evaluate the Tolerability of Eye Drop DA-6034 in Healthy Volunteers
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: DA-6034|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreous Ranibizumab as Adjunctive Treatment for Trabeculectomy in Neovascular Glaucoma
Status: COMPLETED
Conditions: Glaucoma, Neovascular
Interventions: DRUG: intravitreal ranibizumab|PROCEDURE: Trabeculectomy with mitomycinC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Therapy for Advanced Relapsed/Refractory Multiple Myeloma With and Without Dexamethasone
Status: NOT_YET_RECRUITING
Conditions: Multiple Myeloma|Relapse Multiple Myeloma
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Two Different Aflibercept Regimens in Subjects With Neovascular Age-related Macular Degeneration (nAMD)
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Combination of Non-sLip Element Balloon (NSE) and druG-coated bAlloon (DCB) for In-steNT Restenosis Lesions
Status: UNKNOWN
Conditions: Coronary Restenosis
Interventions: DEVICE: Non-slip element balloon (NSE)|DEVICE: Balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ketogenic Diet in Pediatric Intractable Epilepsy
Status: RECRUITING
Conditions: Epilepsy in Children|Epilepsy Intractable
Interventions: DIETARY_SUPPLEMENT: Early ketogenic diet combined with conventional pharmacotherapy.|DRUG: Common diet combined with conventional pharmacotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of the Simultaneous Treatment of Upper Facial Lines (Horizontal Forehead Lines, Glabellar Frown Lines and Crows Feet) in Subjects With Moderate to Severe Upper Facial Lines
Status: COMPLETED
Conditions: Moderate to Severe Upper Facial Lines (Horizontal Forehead Lines, Glabellar Frown Lines, and Lateral Canthal Lines)
Interventions: DRUG: NT 201|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Disc Biacuplasty to Treat Chronic Discogenic Low Back Pain
Status: TERMINATED
Conditions: Low Back Pain
Interventions: DEVICE: Disc biacuplasty|DEVICE: Sham biacuplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety And Pharmacokinetic Study With CVX-045 In Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors|Neoplasms|Carcinoma|Cancer|Malignancy
Interventions: BIOLOGICAL: CVX-045
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tacrobell tab_Phase1_PK
Status: COMPLETED
Conditions: Immunosuppressant(Organ Transplantation, RA)
Interventions: DRUG: Tacrobell tab. 2mg|DRUG: Prograf cap. 2mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of Sci-B-Vac® to Engerix-B® in Adults
Status: COMPLETED
Conditions: Hepatitis B Vaccines
Interventions: BIOLOGICAL: Hepatitis B Vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Three Months-prednisolone Therapy for Chronic Eosinophilic Pneumonia
Status: COMPLETED
Conditions: Eosinophilic Pneumonia|Chronic Disease
Interventions: DRUG: prednisolone 0.5 mg/kg/day for three months|DRUG: prednisolone 0.5 mg/kg/day for six months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of E7070 Combined With Capecitabine to Determine Efficacy and Recommended Dose of Combination in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer (CRC)
Interventions: DRUG: E7070
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atezolizumab in Combination With Stereotactic Body Radiation Therapy (SBRT) and Surgery for Relapsed Osteosarcoma
Status: NOT_YET_RECRUITING
Conditions: Osteosarcoma|Pulmonary Recurrence of Osteosarcoma
Interventions: PROCEDURE: Surgical Resection|RADIATION: Stereotactic Body Radiation Therapy (SBRT)|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SAR240550 in Combination With Gemcitabine/Cisplatin in Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer Stage IV
Interventions: DRUG: Iniparib|DRUG: gemcitabine|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficiency of a Moisturizer Containing Licochalcone A, L-carnitine and 1,2-decanediol With Adapalene Gel in Acne
Status: COMPLETED
Conditions: Acne
Interventions: OTHER: Adapalene gel with Eucerin|OTHER: Adapalene gel|OTHER: Adapalene gel with placebo moisturizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: iCare vs Tonopen vs Goldmann Applanation Post-vitrectomy Surgery
Status: COMPLETED
Conditions: Intraocular Pressure
Interventions: DEVICE: Icare rebound tonometry|DEVICE: Tonopen applanation|DEVICE: Goldmann applanation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Change the Cycle: An RCT to Prevent Injection Initiation
Status: COMPLETED
Conditions: Substance Abuse, Intravenous|HIV|Heroin Dependence|Opioid Dependence|Cocaine Dependence|Amphetamine Dependence
Interventions: BEHAVIORAL: Change the Cycle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of GTR in Comparison to Copaxone®
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Glatiramer Acetate (GTR)|DRUG: Glatiramer Acetate (Copaxone®)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Molecular Biomarkers for Sepsis
Status: TERMINATED
Conditions: Sepsis|Severe Community-acquired Pneumonia (sCAP)|Infection, Bacterial
Interventions: OTHER: compare data patterns by data-driven algorithms to determine sepsis|OTHER: compare data patterns by data-driven algorithms to predict sepsis-related mortality
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Internet-Delivered Positive Affect Program in Managing Emotion in Young Adult Cancer Survivors
Status: COMPLETED
Conditions: Cancer Survivor
Interventions: OTHER: Internet-Based Intervention|PROCEDURE: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Learn About the Study Medicine Etrasimod in Adults With Moderate to Severe Atopic Dermatitis (AD) Who Have Already Tried Treatments Taken by Mouth or by Injection
Status: TERMINATED
Conditions: Atopic Dermatitis|Atopic Dermatitis, Unspecified|Eczema|Eczema, Atopic
Interventions: DRUG: etrasimod|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Gemcitabine + Fractionated Stereotactic Radiotherapy for Unresectable Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DEVICE: CyberKnife based stereotactic radiotherapy|DRUG: Gemcitabine|DRUG: Fludeoxyglucose (18F) (FDG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Perioperative Cardiac Output-guided GDT on Oxygen Delivery, Consumption, and Microcirculatory Perfusion
Status: COMPLETED
Conditions: Caridac Output-guided Goal-directed Hemodynamic Therapy|Oxygen Delivery|Oxygen Consumption|Microcirculatory Perfusion|Major Non-cardiac Surgery|Postoperative Acute Kidney Injury|Postoperative Acute Myocardial Injury
Interventions: OTHER: Treatment algorithms targeting cardiac output
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study for MR Formulation of PF-06650833 in Healthy Adult Japanese Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06650833|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dynamic Cervical Implant in Treatment of Cervical Disc Disease
Status: UNKNOWN
Conditions: Cervical Disc Disease|Cervical Disc Herniation|Cervical Disc Degeneration
Interventions: PROCEDURE: Discectomy and insertion of dynamic cervical implant in cervical disc herniation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Pain Following Thoracic Trauma
Status: ENROLLING_BY_INVITATION
Conditions: Rib Fracture|Rib Fracture Multiple
Interventions: DEVICE: Cryoneurolysis|PROCEDURE: Local anesthetic peripheral nerve block|DEVICE: Sham Cryoneurolysis|PROCEDURE: Sham peripheral nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Integrated HIV/NCD Screening on HIV Testing Uptake and Engagement in HIV Care In Kisarawe, Tanzania
Status: COMPLETED
Conditions: Human Immunodeficiency Virus|Diabetes Mellitus, Type 2|Hypertension
Interventions: DIAGNOSTIC_TEST: Blood glucose and blood pressure testing|BEHAVIORAL: Diet and lifestyle counseling|DRUG: DM/HTN medications as needed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interdisciplinary Mobility Approach To Reduction Of Facility-Acquired Pressure Ulcers
Status: COMPLETED
Conditions: Pressure Ulcers
Interventions: BEHAVIORAL: Musical prompt|BEHAVIORAL: Delayed musical prompt|OTHER: No musical prompt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Embolization in Splenic Trauma
Status: COMPLETED
Conditions: Trauma to the Spleen
Interventions: DEVICE: Splenic artery embolization with vascular embolic coils|DEVICE: Splenic artery embolization with vascular embolic plugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic Clamp
Status: WITHDRAWN
Conditions: Metabolic Disease
Interventions: DIAGNOSTIC_TEST: Hyperglycemic Clamp|DRUG: Kisspeptin-10|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Cetuximab in Combination With Cisplatin Gemcitabine as First-Line Therapy in Advanced NSCLC
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: CETUXIMAB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Evaluation of the KLOX BioPhotonic System in Stage II and III Pressure Ulcers
Status: COMPLETED
Conditions: Pressure Ulcers Stage II|Pressure Ulcers Stage III
Interventions: DEVICE: KLOX BioPhotonic System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Study Comparing Etanercept to Conventional Disease Modifying Antirheumatic Drug (DMARD) Therapy
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Phase 1: Etanercept|DRUG: Phase 1: Methotrexate|DRUG: Phase 2: Optional ETN, SSZ, HCQ, MTX|DRUG: Phase 1: Methotrexate|DRUG: Phase 1: Conventiaonal DMARD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Corticosteroid Treatment in the Acute Phase of Caustic Ingestion Management
Status: UNKNOWN
Conditions: Caustic Esophageal Injury|Esophageal Stenosis|Pharyngeal Stenosis
Interventions: DRUG: Methylprednisolone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ifosfamide, Doxorubicin and Hypofractionated Radiotherapy in Neoadjuvant Sarcoma Treatment
Status: UNKNOWN
Conditions: Sarcoma, Soft Tissue
Interventions: DRUG: Doxorubicin|DRUG: Ifosfamide|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Among Propofol, Alfentanil and Rocuronium as Adjunct to Sevoflurane Anesthesia for Endotracheal Intubation in Children With Frenectomy
Status: COMPLETED
Conditions: Ankyloglossia
Interventions: DRUG: administration of propofol|DRUG: administration of alfentanil|DRUG: administration of rocuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effect of Different Final Irrigation Protocols on Postoperative Endodontic Pain in Devital Teeth
Status: COMPLETED
Conditions: Postoperative Pain|Endodontically Treated Teeth
Interventions: PROCEDURE: EDTA and CHX Solution|PROCEDURE: EDTA Solution|PROCEDURE: CHX Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus
Status: TERMINATED
Conditions: Keratoconus
Interventions: DRUG: riboflavin solution|DRUG: placebo solution|DEVICE: KXL System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Relaxant Effect of Nitroglycerin on Oxytocin Desensitized Human Myometrium
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Oxytocin|DRUG: Nitroglycerin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of VR on Pain, Fear and Anxiety During Accessing a Port With Huber Needle in Pediatric Cancer Patients
Status: COMPLETED
Conditions: Pain|Fear|Anxiety State
Interventions: DEVICE: wearing the virtual headset
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Resuscitation With Albumin 5% in Dengue Haemorrhagic Fever
Status: UNKNOWN
Conditions: Dengue Hemorrhagic
Interventions: DRUG: Albumins|DRUG: Fluid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Brentuximab Vedotin Treatment in Chinese Adults With CD30-Positive Cutaneous T-Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: T-Cell Lymphoma
Interventions: DRUG: Brentuximab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-world Treatment Patterns and Effectiveness of Palbociclib and AI Therapy
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Palbociclib + an aromatase inhibitor|DRUG: Palbociclib + Letrozole|DRUG: Letrozole
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Magnesium as an Adjunct for Pain Treatment After Surgery for Thumb Base Arthrosis
Status: TERMINATED
Conditions: Thumb Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: magnesiumcitrate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Weight-bearing Mechanical Axis on Foot and Ankle in Patients Following Total Knee Arthroplasty
Status: RECRUITING
Conditions: Total Knee Artroplasty
Interventions: RADIATION: Postero-anterior weight-bearing full-leg radiograph|DEVICE: Pedobarographic analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: AV-101 Alone and in Combination With Probenecid in Healthy Subjects
Status: UNKNOWN
Conditions: Drug Drug Interaction
Interventions: DRUG: AV-101|DRUG: Probenecid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Role of Trans-spinal Direct Current Stimulation (tsDCS) in Treating Patients With Hand Spasticity After Stroke
Status: COMPLETED
Conditions: Stroke|Cerebrovascular Accident (CVA)|Hemiparesis|Spasticity as Sequela of Stroke|Muscle Spasticity|Upper Extremity Paralysis
Interventions: DEVICE: sham Doublestim|DEVICE: anodal Doublestim
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Immune Modulation by Modern Acupuncture in Gastroenterologic Cancers
Status: COMPLETED
Conditions: Hepatocellular Cancer|Gastrointestinal Cancer|Immunosuppression
Interventions: OTHER: Modern acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Incretin Effect in PCOS Women
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Valacyclovir vs. Acyclovir as HSV-2 Suppressive Therapy: Effect on Plasma HIV-1 Levels Among HIV-1/HSV-2 Co-infected Persons
Status: COMPLETED
Conditions: HSV Infection|HIV Infection
Interventions: DRUG: acyclovir|DRUG: valacyclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Clinical Study of Transthoracic Single-hole Assisted Laparoscopic Radical Gastrectomy for Siewert Ⅱ AEG
Status: UNKNOWN
Conditions: Esophagogastric Junction Adenocarcinoma|Siewert Type II Adenocarcinoma of Esophagogastric Junction
Interventions: PROCEDURE: Transthoracic Single-hole Assisted Laparoscopic Radical Gastrectomy for Siewert Type Ⅱ Adenocarcinoma of Esophagogastric Junction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Increased Free Fatty Acids on Leptin Function
Status: COMPLETED
Conditions: Obesity|Leptin Resistance
Interventions: DRUG: Saline|DRUG: Intralipid|DIETARY_SUPPLEMENT: Water|DIETARY_SUPPLEMENT: oral fat|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Correlation Between Monitoring Frequency and Clinical Deterioration in Hospitalized Patients
Status: COMPLETED
Conditions: In-hospital Deterioration|Intra Hospital Cardiac Arrest|Sudden Death
Interventions: OTHER: Control group|OTHER: Increased monitoring frequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial of Melaxin Cancer Vaccine Plus Bacillus Calmette-Guerin (BCG) to Treat Malignant Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: BIOLOGICAL: Melaxin (autologous dendritoma vaccine) and BCG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Prevalence of BPPV and Longterm Effects of Its Therapy Using the Rotundum Device in Retirement Homes
Status: COMPLETED
Conditions: Benign Paroxysmal Positional Vertigo
Interventions: DIAGNOSTIC_TEST: Epley maneuver/Barbeque maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Skin Incision Closure Material for the Transobturator Suburethral Sling Procedure
Status: COMPLETED
Conditions: Pain, Postoperative|Irritation (Physical)|Pelvic Pain
Interventions: PROCEDURE: Vicryl Suture|PROCEDURE: Dermabond
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Inflammatory Signal Inhibitors for COVID-19 (MATIS)
Status: UNKNOWN
Conditions: Coronavirus|Covid19|Pneumonia
Interventions: DRUG: Ruxolitinib|DRUG: Fostamatinib|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Plasma and Urine TMAO Formation and Changes to Oxidized LDL After Ingestion of Different Amounts of Egg
Status: COMPLETED
Conditions: Biomarkers of Cardiovascular Disease
Interventions: OTHER: Egg Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Mobile Intervention to Improve Functional Health and Community Engagement of Post-9/11 Veterans With Chronic Insomnia
Status: COMPLETED
Conditions: Chronic Insomnia
Interventions: BEHAVIORAL: CBTI app intervention|BEHAVIORAL: Physical Activity intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation Into the Safety of Intradermal Juvidex (M6P) Administered to Wounds of Healthy Subjects
Status: COMPLETED
Conditions: Cicatrix|Re-epithelialisation
Interventions: DRUG: Juvidex|DRUG: Juvidex|DRUG: Juvidex|DRUG: Juvidex|DRUG: Juvidex|DRUG: Juvidex|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Beetroot Juice Doses and Anaerobic Performance
Status: COMPLETED
Conditions: Anaerobic Exercise|Dietary Supplementations
Interventions: DIETARY_SUPPLEMENT: Beet It Sport Shot|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Supplement Adjuvant Capecitabine in HR+/HER2- Breast Cancer Patients With High Risks
Status: RECRUITING
Conditions: Breast Cancer|Chemotherapy Effect
Interventions: DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contact Cast Versus Posterior Slab as Offloading Modality for Charcot Neuroarthropathy
Status: NOT_YET_RECRUITING
Conditions: Charcot Neuroarthropathy
Interventions: OTHER: Total Contact Cast|OTHER: Posterior Slab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Assessment of 18F-fluciclovine and 18F-FDG -PET/MRI of Primary Central Nervous System Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin|Central Nervous System Neoplasms
Interventions: DIAGNOSTIC_TEST: 18F-FDG|DIAGNOSTIC_TEST: 18F-fluciclovine|DIAGNOSTIC_TEST: standard MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cyclin Dependant Kinase 4/6 (CDK4/6) Inhibitors as a Second Line Treatment in Metastatic Breast Cancer Patients
Status: RECRUITING
Conditions: Breast Cancer Stage IV
Interventions: DRUG: comparing both arms as regard the objective response rate, toxicity profile, quality of life, progression free survival
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Haplotype Mismatched HSCT in Patients With Hematological Malignancies
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Myelodysplasia|Chronic Myeloid Leukemia
Interventions: RADIATION: Total Body Irradiation|DRUG: Thiotepa|DRUG: Fludarabine|BIOLOGICAL: Rabbit ATG|DRUG: Palifermin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Safety & Efficacy of Subcutaneous Methylnaltrexone on Opioid-Induced Constipation in Cancer Subjects
Status: WITHDRAWN
Conditions: Opioid-Induced Constipation
Interventions: DRUG: methylnaltrexone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Cerebral Vasoreactivity Using Near-infrared Spectroscopy (NIRS) in Infants (VARO)
Status: COMPLETED
Conditions: Hypercapnia
Interventions: OTHER: Normocapnia|OTHER: Mild Hypercapnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Inhaled Pre-prandial Human Insulin on Blood Glucose Control in Type 2 Diabetes
Status: TERMINATED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: rosiglitazone|DRUG: inhaled human insulin|DRUG: metformin|DRUG: glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Mindfulness-based Breathing Therapy
Status: COMPLETED
Conditions: Palliative Supportive Care|Care Giving Burden
Interventions: OTHER: Mindfulness-based breathing therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase I Clinical Trial for Comparison of Pharmacokinetic Characteristics of Vorico Injection 200mg(Voriconazole) and Vfend® IV 200mg for Single Dose Crossover Intravenous Infusion in Healthy Volunteers
Status: COMPLETED
Conditions: Aspergillus Infections|Candida Infections|Fungal Infections
Interventions: DRUG: Vorico Injection 200mg(Voriconazole)|DRUG: Vfend®(Voriconazole) IV 200mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ramucirumab and Pembrolizumab for the Treatment of EGFR Mutant Recurrent or Metastatic Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Lung Non-Small Cell Carcinoma|Recurrent Lung Non-Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Ramucirumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anakinra With or Without Dexamethasone in Treating Patients With Smoldering or Indolent Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: Anakinra (IL-1Ra)|DRUG: Dexamethasone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Outcome After Anastomotic Leak After Oesophagectomies
Status: NOT_YET_RECRUITING
Conditions: Anastomotic Leak Esophagus|Swallowing Disorder
Interventions: PROCEDURE: Anastomotic Leak after Ivor Lewis Oesophagectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p