pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Bioavailability and Pharmacokinetic Parameters of Watermelon (Rind, Flesh and Seeds) Polyphenols
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DIETARY_SUPPLEMENT: Watermelon Rind|DIETARY_SUPPLEMENT: Watermelon Flesh|DIETARY_SUPPLEMENT: Watermelon Seeds|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Multimodal Sleep Pathway for Shoulder Arthroplasty
Status: COMPLETED
Conditions: Sleep Disturbance|Shoulder Arthritis|Arthroplasty Complications|Perioperative/Postoperative Complications
Interventions: DRUG: Zolpidem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Zevalin and Simultaneous Application of BEAM High-dose Chemotherapy Followed by Autologous Stem Cell Transplantation in Refractory and Relapsed Aggressive Non-Hodgkin Lymphomas
Status: COMPLETED
Conditions: Primary Non-Hodgkin-Lymphoma|Refractory Non-Hodgkin-Lymphoma|CD20+ Aggressive Non-Hodgkin's Lymphoma
Interventions: DRUG: Zevalin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of High-Flow Hemodialysis Catheters Placed From the Left Internal Jugular Vein(R12-022)
Status: WITHDRAWN
Conditions: End Stage Renal Disease on Dialysis (Diagnosis)
Interventions: DEVICE: Tunneled dialysis catheter placement.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Dabrafenib and Trametinib in People With BRAF V600E Mutation Positive Lesions in Erdheim Chester Disease
Status: COMPLETED
Conditions: BRAF V600E Mutation
Interventions: DRUG: Dabrafenib Mesylate|DRUG: Trametinib Dimethyl Sulfoxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Testing Fractional Radiofrequency Versus Fractional Photothermolysis for the Treatment of Acne Scars
Status: ACTIVE_NOT_RECRUITING
Conditions: Cicatrix
Interventions: DEVICE: Fractional Radiofrequency|DEVICE: 1550-nm Fractional Photothermolysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Histology of the Bladder Wall for Bladder Cancer Staging
Status: RECRUITING
Conditions: Urinary Bladder Neoplasms
Interventions: DIAGNOSTIC_TEST: Magnetic Resonance Imaging|DRUG: Gadobutrol intravesical administration (4mM)|DRUG: Ferumoxytol intravesical administration (5 mM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Debio 0123 in Combination With Carboplatin and Etoposide in Adult Participants With Small Cell Lung Cancer That Recurred or Progressed After Previous Standard Platinum-Based Therapy
Status: RECRUITING
Conditions: Small Cell Lung Cancer Recurrent
Interventions: DRUG: Debio 0123|DRUG: Etoposide|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Assess the Effects of SRT2104 and Prednisolone on Biomarkers in Blood in Healthy Volunteers
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Placebo|DRUG: 0.25g SRT2104|DRUG: Prednisolone|DRUG: 0.5g SRT2104|DRUG: 1g SRT2104|DRUG: 2g SRT2104
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Desoximetasone Spray 0.25% in Patients With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Desoximetasone Spray 0.25%|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimisation of Primary HIV1 Infection Treatment(ANRS 147 OPTIPRIM)
Status: COMPLETED
Conditions: HIV-1 Infections
Interventions: DRUG: raltegravir; maraviroc; darunavir; ritonavir; tenofovir/emtricitabine|DRUG: darunavir; ritonavir; emtricitabine/tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultra-high-resolution CT vs. Conventional Angiography for Detecting Coronary Heart Disease
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: CT angiography|DIAGNOSTIC_TEST: Invasive coronary angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Far Infrared Irradiation for the Management, Control and Treatment of Frontotemporal Dementia
Status: UNKNOWN
Conditions: Pick Disease of the Brain
Interventions: RADIATION: Radiation: Far Infrared Radiation (5μm to 20μm wavelength)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Traumatic Brain Injury Biological Diagnosis Via High Definition Tractography Asymmetry Screening
Status: WITHDRAWN
Conditions: Traumatic Brain Injury
Interventions: PROCEDURE: MRI of the Brain (No Contrast) Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: To Investigate the Effect of Far-infrared Radiation on Lower Extremity Acupoints on the Blood Circulation of Lower Extremities in Patients With Hemodialysis
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: far-infrared radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Garlic Supplements on Opioids in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy, No Evidence of Disease
Interventions: DIETARY_SUPPLEMENT: garlic powder tablets|DRUG: oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Stem Cell Transplant Therapy With Campath-1H for Treating Advanced Mycosis Fungoides and Sezary Syndrome
Status: COMPLETED
Conditions: Mycosis Fungoides|Sezary Syndrome
Interventions: OTHER: A matched peripheral donor stem cells|DRUG: cyclosporine|DRUG: fludarabine|DRUG: Campath
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Growth Hormone (GH) in in Vitro Fertilization (IVF) Poor-responder Patients
Status: TERMINATED
Conditions: Complications; Artificial Fertilization, Introduction of Embryo in Embryo Transfer
Interventions: DRUG: Somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ivosidenib, Nivolumab, and Ipilimumab Combination in Previously Treated Subjects With Nonresectable or Metastatic IDH1 Mutant Cholangiocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: IDH1-mutant Cholangiocarcinoma
Interventions: DRUG: Ivosidenib|DRUG: Recommended Combination Dose (RCD) of ivosidenib|DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Soy Phytoestrogens to Prevent Bone Loss
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Soy isoflavones|DIETARY_SUPPLEMENT: Soy isoflavones
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Safety and Efficacy of Pomalidomide in Combination With Cyclophosphamide and Dexamethasone (PCD) in the Transplant-ineligible Patients With Relapsed and/or Refractory Multiple Myeloma (MM)
Status: COMPLETED
Conditions: Relapsed and/or refractorY Multiple Myeloma
Interventions: DRUG: Pomalidomide 4 MG|DRUG: Dexamethasone 20mg|DRUG: Cyclophosphamide 400mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Superiority Randomized Controlled Trial of Ultrasound-guided PENG Block Compared to Surgical Infiltration in the Analgesia of Posterior Total Hip Arthroplasty Surgery
Status: RECRUITING
Conditions: Hip Arthropathy|Hip Arthrosis
Interventions: PROCEDURE: Surgical infiltration|PROCEDURE: PENG Block ultrasound-guided
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Use of Bortezomib for the Treatment of Relapsed Leukemia or Positive MRD
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia, in Relapse|Chemotherapeutic Toxicity|Minimal Residual Disease
Interventions: DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Cyberknife Stereotactic Radiation Therapy (SBRT) Followed by Gemcitabine for Patients With Locally Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer|Unresectable Pancreatic Cancer
Interventions: RADIATION: stereotactic body radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)
Status: RECRUITING
Conditions: Coarctation of Aorta|High Blood Pressure
Interventions: DRUG: Losartan|DRUG: Amlodipine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Efficacy of Somatropin in the Treatment of Patellar Tendinopathy
Status: WITHDRAWN
Conditions: Tendinopathy
Interventions: DRUG: Somatropin|DRUG: Bacteriostatic saline|OTHER: Progressive exercise program|PROCEDURE: Patellar tendon biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial of Firesorb in Patients With Coronary Artery Disease: FUTURE-II
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: Firesorb|DEVICE: XIENCE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety, PK and Efficacy of PCS12852 on Gastric Emptying Rate in Patients With Moderate to Severe Gastroparesis
Status: COMPLETED
Conditions: Gastroparesis
Interventions: DRUG: PCS12852|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Anti-PD1 (Nivolumab) Therapy as Pre- and Post-operative Therapy in Metastatic Renal Cell Cancer (ADAPTeR)
Status: UNKNOWN
Conditions: Renal Cell Carcinoma
Interventions: DRUG: nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Bevacizumab + Chemotherapy Combined With Short-course Radiotherapy
Status: RECRUITING
Conditions: Neoadjuvant Treatment|Rectal Cancer|Bevacizumab|Radiotherapy
Interventions: DRUG: Bevacizumab+mFOLFOX6
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Augmenting Response to Entecavir With Peginterferon a-2a for the Treatment of HBeAg-positive Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: pegylated interferon a-2a|DRUG: Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Collect and Assess Long-term Safety of Everolimus in Patients Who Are on Everolimus Treatment in a Novartis-sponsored Study and Are Benefiting From the Treatment as Judged by the Investigator.
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Superiority of VAsopressin Versus NOradrenaline in the Management of Patients at Risk of Kidney Failure Undergoing Cardiac Surgery With Extracorporeal Circulation
Status: RECRUITING
Conditions: Scheduled Cardiac Surgery With Extracorporeal Circulation|Vasoplegic Syndrome
Interventions: DRUG: Vasopressin|DRUG: Norepinephrine|OTHER: Collection of clinical data|OTHER: Quality of Life Questionnaire EQ-5D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tackling Postnatal Depression: Culturally Adapted Learning Through Play Plus (LTP+) Intervention for British Mothers of African and Caribbean Origin
Status: NOT_YET_RECRUITING
Conditions: Postnatal Depression
Interventions: BEHAVIORAL: Learning Through Play plus (LTP+)|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects and Mechanisms of Treatment Intensity of Mirror Therapy in Patients With Subacute Stroke
Status: COMPLETED
Conditions: Cerebrovascular Accident
Interventions: BEHAVIORAL: MT with low-intensity group (MT-LI)|BEHAVIORAL: MT with moderate-intensity group|BEHAVIORAL: Mirror therapy with high intensity group|BEHAVIORAL: Control intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Chain Fatty Acid Oxidation Disorders (LC-FAOD) Extension Study for Subjects Previously Enrolled in Triheptanoin Studies
Status: COMPLETED
Conditions: Carnitine Palmitoyltransferase (CPT I or CPT II) Deficiency|Very Long Chain Acyl-CoA Dehydrogenase (VLCAD) Deficiency|Long-chain 3-hydroxy-acyl-CoA Dehydrogenase (LCHAD) Deficiency|Trifunctional Protein (TFP) Deficiency|Carnitine-acylcarnitine Translocase (CACT) Deficiency
Interventions: DRUG: UX007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Function With Various Storage Techniques
Status: WITHDRAWN
Conditions: Platelet Dysfunction Due to Drugs
Interventions: BIOLOGICAL: Infusion of Platelets|BIOLOGICAL: Infusion of Platelets|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Proof of Science, Dose-Response Study to Evaluate the Safety, Efficacy of Different Dosages of Test Treatments
Status: COMPLETED
Conditions: Mild to Moderate Acne|Stiffness of Joint, Nec, Involving Ankle and Foot in MDR24_1|Other Specified Diseases of Hair and Hair Follicles|Brittle Nails|Osteoarthritis, Knee|Healthy
Interventions: DIETARY_SUPPLEMENT: Veg Collagen Peptide|DIETARY_SUPPLEMENT: Bovine Collagen Peptide|DIETARY_SUPPLEMENT: Fish | Marine Collagen Peptide|DIETARY_SUPPLEMENT: Chicken Collagen Peptide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability and Host Response to Lactobacillus Johnsonii
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: L. johnsonii N6.2|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Missing Pieces Trial: A Comparison of Two Interventions to Support Parents After Their Child's Unexpected or Traumatic Death
Status: RECRUITING
Conditions: Bereavement
Interventions: OTHER: CommunityRx-Bereavement|OTHER: General Bereavement Support Information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Very Low Calories Ketogenic Diet in Migraine.
Status: COMPLETED
Conditions: Migraine|Overweight and Obesity
Interventions: BEHAVIORAL: Ketogenic diet|BEHAVIORAL: Sham Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assess the Performance of Metagenomic Sequencing in the Diagnosis of STI (NGS-IST)
Status: RECRUITING
Conditions: Sexually Transmitted Infections (Not HIV or Hepatitis)|Chlamydia Trachomatis Infection|Neisseria Gonorrhoeae Infection|Mycoplasma Genitalium Infection
Interventions: DIAGNOSTIC_TEST: Assess the Performance of Metagenomic Sequencing in the Diagnosis of STI (NGS-IST)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Telehealth Cognitive Behavioral Therapy for Youth at Risk for Psychosis
Status: RECRUITING
Conditions: Clinical High Risk for Psychosis (CHR)
Interventions: BEHAVIORAL: CBT Skills Group for CHR Youth|BEHAVIORAL: Individual CBT sessions|BEHAVIORAL: CBT Skills Group for Families
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Sitagliptin Hydrochloride / Metformin Hydrochloride Extended-release Film Coated Tablets 100 mg /1000 mg (FDC) in Healthy Adult Male and Female Subjects Under Fasting Conditions.
Status: COMPLETED
Conditions: Bioequivalence|Diabetes Mellitus, Type 2
Interventions: DRUG: Sitagliptin/Metformin HCl 100/1000 mg extended release film-coated tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effects of Resveratrol Supplementation on Measurements of Health and Human Performance
Status: UNKNOWN
Conditions: Inflammation
Interventions: DIETARY_SUPPLEMENT: resveratrol|OTHER: Placebo Comparator: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Orthognathic Speech Pathology: Phonetic Contrasts of Patients With Dental Discrepancies Pre- and Post-Treatment Analyses
Status: RECRUITING
Conditions: Dentofacial Abnormalities|Dentofacial Deformities|Dentofacial Anomalies, Including Malocclusion|Malocclusion|Malocclusion in Children|Dentofacial Disharmony|Skeletal Malocclusion|Skeletal Malformation|Speech Sound Disorder|Speech Disorders
Interventions: OTHER: Orthognathic surgery and Orthodontics
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of 0.25% Timolol Gel in Enhancing Full Thickness Skin Grafts Healing and Cosmetic Outcomes
Status: TERMINATED
Conditions: Wound of Skin|Wound Heal|Surgical Wound|Full Thickness Skin Graft Healing
Interventions: DRUG: 0.25% timolol gel with full-thickness skin grafts|OTHER: Vaseline dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Cyclosporine 100mg Capsule Under Fasting Condition
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Cyclosporine Capsules USP (Modified) 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Closing the Loop in Adults With Type 1 Diabetes Under Free Living Conditions (AP@Home04_Phase 4)
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: Hybrid closed-loop using ultra-rapid insulin lispro|DEVICE: Hybrid closed-loop using standard insulin lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pendant Position and Traditional Sitting Position for Successful Spinal Puncture in Spinal Anaesthesia
Status: COMPLETED
Conditions: Pregnancy, Caesarean Section
Interventions: PROCEDURE: Traditional sitting position|PROCEDURE: Pendant position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preventing the Progression of Multiple Sclerosis: Early Rehabilitative Treatment and Multimodal Assessment - Part B
Status: ENROLLING_BY_INVITATION
Conditions: Multiple Sclerosis
Interventions: OTHER: Tailored Physical Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of RAY1216 Tablets Compared With Placebo in Patients With Mild to Moderate COVID-19
Status: COMPLETED
Conditions: Mild to Moderate COVID-19
Interventions: DRUG: RAY1216|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Alternate Methodology of Pulse Oximeter Validation
Status: SUSPENDED
Conditions: Hypoxemia|Desaturation of Blood
Interventions: DEVICE: RespirAct Step-Wise Normocapnia desaturation sequence|DEVICE: RespirAct Slope Normocapnia desaturation sequence|DEVICE: RespirAct Step-Wise Hypocapnia desaturation sequence|DEVICE: RespirAct Slope Hypocapnia desaturation sequence|DEVICE: ROBD Step-Wise desaturation sequence
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Resting Full-cycle Ratio (RFR)-Guided Revascularization
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: Resting full-cycle ratio (RFR)-guided revascularization|DIAGNOSTIC_TEST: Fractional flow ratio (FFR)-guided revascularization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: VIR-7831 for the Early Treatment of COVID-19 in Outpatients
Status: COMPLETED
Conditions: Covid19
Interventions: BIOLOGICAL: VIR-7831 (sotrovimab)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Longitudinal Tracking and Intervention Platform for Medicare Advantage Patients
Status: NOT_YET_RECRUITING
Conditions: Frailty
Interventions: BEHAVIORAL: Longitudinal Tracking and Intervention Platform for Medicare Advantage Patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Mesenchymal Stem Cell Transplantation in Decompensated Cirrhosis
Status: COMPLETED
Conditions: Cirrhosis
Interventions: PROCEDURE: Autologous mesenchymal stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bone Markers and Bone Density Changes in Hyperperparathyroid Dialysis Patients Under Cinacalcet Treatment
Status: COMPLETED
Conditions: Hyperparathyroidism; Secondary, Renal
Interventions: DRUG: Cinacalcet Tablets|DRUG: calcitriol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metabolic Analysis in Human Sulfur Amino Acid Deficiency
Status: COMPLETED
Conditions: Oxidative Stress|Diabetes|Heart Diseases
Interventions: DRUG: dietary amino acids; cysteine and methionine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Nutritional Formula Supplementation on Linear Growth of Growth Hormone (GH) Treated Prepubertal Children With Idiopathic Short Stature (ISS) After 2 Years From the Beginning of GH-therapy
Status: RECRUITING
Conditions: ISS- Idiopathic Short Stature
Interventions: DIETARY_SUPPLEMENT: Nutritional supplementation standardized formula|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Use of Tadekinig Alfa in NLRC4 Mutation and XIAP Deficiency
Status: COMPLETED
Conditions: NLRC4-MAS|XIAP Deficiency
Interventions: DRUG: Tadekinig alfa|OTHER: 0.9% sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effects of Itraconazole on the Pharmacokinetics of BMS-986256 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: BMS-986256|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Psyllium and Wheat Bran on Body Weight in People With Parkinson's Disease and Constipation Symptoms
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DIETARY_SUPPLEMENT: Psyllium|DIETARY_SUPPLEMENT: Coarse wheat bran|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of a Personalized Neurofeedback Training Device (ADHD@Home) in Attention-Deficit/Hyperactivity Disorder
Status: UNKNOWN
Conditions: Attention Deficit-Hyperactivity Disorder
Interventions: DEVICE: Neurofeedback NFT|DRUG: Methylphenidate MPH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab for Serious Aplastic Anemia With Platelet Transfusion Refractoriness
Status: RECRUITING
Conditions: Severe Aplastic Anemia|Platelet Transfusion Refractoriness
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study of Activity, Safety, and Tolerance of Oral Ro 24-7429 (Tat Antagonist) in Patients With HIV Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Ro 24-7429|DRUG: Zidovudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Deep Dive Randomized Control Trial
Status: COMPLETED
Conditions: Chronic Disease|Arthritis|Uterine Diseases|Spinal Diseases|Preventive Health Services
Interventions: BEHAVIORAL: Enhanced Support|BEHAVIORAL: Usual-Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Efficacy of Adjunctive Antimicrobial Photodynamic Therapy for Residual Pockets in Previously Surgically Treated Teeth
Status: UNKNOWN
Conditions: Periodontitis
Interventions: DEVICE: Antimicrobial photodynamic therapy|DEVICE: Placebo of photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Durvalumab Combined to Neoadjuvant Chemotherapy in Localized Luminal B HER2(-) and Triple Negative Breast Cancer.
Status: COMPLETED
Conditions: Breast Cancer|Triple Negative Breast Cancer|Luminal B
Interventions: DRUG: Paclitaxel|DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microbicide Safety and Acceptability in Young Men
Status: COMPLETED
Conditions: High Risk MSM|HIV Negative|18-30 Years of Age
Interventions: OTHER: HEC Placebo Gel|DRUG: Tenofovir 1% Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oral Azithromycin Versus Doxycycline in Posterior Blepharitis
Status: COMPLETED
Conditions: Posterior Blepharitis
Interventions: DRUG: Azithromycin|DRUG: Doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: GA Levonorgestrel Intrauterine Contraceptive System (LCS) Phase III Study China
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Levonorgestrel IUS (LCS, BAY86-5028)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Radiotherapy for Recurrent Prostate Cancer
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer Recurrence After Radical Prostatectomy
Interventions: RADIATION: Stereotactic ablative radiotherapy|RADIATION: Current standard template-based salvage therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: German Evaluation of the Effectiveness of the Psychological Intervention Managing Cancer and Living Meaningfully (CALM)
Status: COMPLETED
Conditions: Depression|Psychological Distress
Interventions: BEHAVIORAL: Manualized CALM intervention|BEHAVIORAL: Non-manualized supportive intervention.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Tofacitinib in Patients With Recalcitrant Frontal Fibrosing Alopecia : A Pilot Study
Status: ENROLLING_BY_INVITATION
Conditions: Frontal Fibrosing Alopecia|Lichen Planopilaris
Interventions: DRUG: Tofacitinib 5 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Trial of Diffusing Alpha-emitter Radiation Therapy (DaRT) for Malignant Skin & Superficial Soft Tissue Tumors
Status: COMPLETED
Conditions: Malignant Skin Tumor|Soft Tissue Tumor, Malignant
Interventions: RADIATION: Diffusing Alpha-emitter Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Etanercept on Skin and Joint Disease in Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: etanercept|DRUG: etanercept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Manipulation, Exercise, and Self-Care for Neck Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: PROCEDURE: Chiropractic + Supervised Rehabilitative Exercise|PROCEDURE: Supervised Rehabilitative Exercise|BEHAVIORAL: Self-care education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Steroids In The Management Of Acute Asthma Exacerbations In Children, Which Form Is More Suitable?
Status: UNKNOWN
Conditions: Steroids In Management Of Acute Asthma Exacerbations
Interventions: DRUG: Dexamethasone 8Mg Solution for Injection|DRUG: Prednisolone Oral, Per 5 Mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Bupivacaine Single-Injection Interscalene Block vs. Continuous Interscalene Block for Primary Total Shoulder Arthroplasty
Status: COMPLETED
Conditions: Pain, Postoperative|Brachial Plexus Block
Interventions: DRUG: Bupivacaine HCl|DRUG: Liposomal bupivacaine + Bupivacaine Hcl 0.5% Inj
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of the F-Composite 2 System in Direct Filling Therapy
Status: COMPLETED
Conditions: Dental Caries|Unsatisfactory or Defective Restoration of Tooth
Interventions: DEVICE: F-Composite 2 system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of CBT Intervention to Improve Sleep on Wellbeing, Dietary Intake and Food Preference
Status: COMPLETED
Conditions: Sleep|Diet|Well Being
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy for Insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bortezomib and Gemcitabine Hydrochloride in Treating Patients With Relapsed or Refractory Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: bortezomib|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Rehabilitation for the Repair of Pelvic Floor Injuries Associated to Vaginal Delivery Identified by 3/4D Transperineal Ultrasound
Status: COMPLETED
Conditions: Pelvic Floor Disorders|Ultrasound Therapy; Complications|Physical Disorder|Obstetric Labor Complications
Interventions: OTHER: Physiotherapy treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: P2 Multi-center Study of SB204 Gel in the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: SB204 2%|DRUG: SB204 4%|DRUG: Vehicle Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Arresting Active Dentine Lesions and Quality of Life Among a Group of Preschool Children
Status: COMPLETED
Conditions: Caries Arrest
Interventions: DRUG: 38 % silver diamine fluoride|PROCEDURE: Atraumatic restorative technique|PROCEDURE: Ultra conservative dentistry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Randomised, Open-label, Three-way Crossover Study to Assess the Pharmacokinetics and Safety of Single Doses of Four Sprays of Sativex® in a Range of Oral pH Environments in Healthy Subjects
Status: TERMINATED
Conditions: Healthy Volunteers
Interventions: DRUG: Sativex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of Viscum Album Mother Tincture as an Anti-hypertensive in Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Viscum album ethanolic extract manufactured according to Homoeopathic pharmacopoeia of India (H.P.I.)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Avapritinib in Relapsed or Refractory Pediatric CBF-AML With KIT Mutation
Status: RECRUITING
Conditions: AML, Childhood|Relapse/Recurrence|Refractory AML|Core Binding Factor Acute Myeloid Leukemia|C-KIT Mutation
Interventions: DRUG: Avapritinib|DRUG: Azacitidine Injection|DRUG: Decitabine Injection|DRUG: Idarubicin Hydrochloride|DRUG: Cytarabine|DRUG: Granulocyte Colony-Stimulating Factor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of BDP HFA Nasal Aerosol in Patients 12 Years and Older With SAR
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis|Hayfever
Interventions: DRUG: Beclomethasone dipropionate HFA Nasal Aerosol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Lacidofil® STRONG in Healthy Adults Taking Antibiotic Treatment
Status: COMPLETED
Conditions: Antibiotic Associated Diarrhea
Interventions: DIETARY_SUPPLEMENT: Lacidofil® STRONG|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Percutaneous Diskectomy SpineJet x Open Microdiskectomy in Treatment of Lumbar Radiculopathy
Status: COMPLETED
Conditions: Radiculopathy|Herniated Disk
Interventions: PROCEDURE: Open microdiscectomy|PROCEDURE: Percutaneous Diskectomy SpineJet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LUCAS (Lucentis Compared to Avastin Study)
Status: COMPLETED
Conditions: Exudative Age-related Macular Degeneration
Interventions: DRUG: Bevacizumab|DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of an Anterior Chamber Maintainer as a Sole Fluid Source in Micro Incision Cataract Surgery as Compared to a Standard Phacoemulsification Procedure
Status: UNKNOWN
Conditions: Cataract
Interventions: PROCEDURE: Phacoemulsification using an ACM as the sole fluid source|PROCEDURE: Conventional Phaco
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effectiveness of Higher Aspirin Dosing for Prevention of Preeclampsia in High Risk Obese Gravida
Status: COMPLETED
Conditions: Pre-Eclampsia|Hypertension in Pregnancy|Obesity
Interventions: DRUG: Aspirin 81 mg|DRUG: Aspirin 162 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Systemic Central Nervous System Prophylaxis in Diffuse Large B-cell Lymphoma
Status: WITHDRAWN
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: Methotrexate|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Radiation Therapy With or Without Fluorouracil in Treating Patients With Cancer of the Stomach Who Have Undergone Surgery
Status: COMPLETED
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: DRUG: cisplatin|DRUG: paclitaxel|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Phase 1 Randomized Double-blind Placebo Controlled Study to Evaluate Safety and PK of MEDI3902 in Healthy Adults
Status: COMPLETED
Conditions: MEDI3902 for Prevention of P. Aeruginosa Pneumonia
Interventions: DRUG: MEDI3902 - Dose 1|DRUG: MEDI3902 - Dose 2|DRUG: MEDI3902 - Dose 3|DRUG: MEDI3902 - Dose 4|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Research Study of V3381 for the Treatment of Diabetic Peripheral Neuropathic Pain
Status: COMPLETED
Conditions: Pain|Diabetic Neuropathies
Interventions: DRUG: V3381|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Select Drug Combinations in Adult Patients With Advanced/Metastatic BRAF V600 Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: BRAF V600 Colorectal Cancer
Interventions: DRUG: Dabrafenib|DRUG: LTT462|DRUG: Trametinib|DRUG: LXH254|DRUG: TNO155|BIOLOGICAL: Spartalizumab|BIOLOGICAL: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Image-Guided Neoadjuvant Ablative Radiation Then Lumpectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Early Stage Breast Carcinoma
Interventions: RADIATION: Stereotactic Body Radiation Then Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quality Initiative to Improve Glucose Control in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: Usual Care|BEHAVIORAL: Intensive Behavioral Intervention|OTHER: Monthly Screening for Risk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Evaluation of Vitiligous Lesions Repigmentation After Topical Administration of Methotrexate in Patients With Active Vitiligo
Status: COMPLETED
Conditions: Non-segmental Vitiligo
Interventions: DRUG: 1% Methotrexate gel|DRUG: 0.5% Methotrexate gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RCT of Different Effects of Nucleot(s)Ide Analogues on the Prognosis of HBV-HCC Patients After Curative Resection
Status: ACTIVE_NOT_RECRUITING
Conditions: HCC|HBV Coinfection
Interventions: DRUG: Tenofovir Disoproxil|DRUG: Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A DDI Study of JMKX000623 and Metformin Hydrochloride
Status: COMPLETED
Conditions: Healthy|Drug-Drug Interaction
Interventions: DRUG: JMKX000623|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Promoting Stretching Exercise to Reduce Cardiovascular Health Risk in Late Pregnant Women With Obesity
Status: ACTIVE_NOT_RECRUITING
Conditions: Pregnancy Related|Cardiovascular Risk Factor|Obesity
Interventions: BEHAVIORAL: Stretching Exercise Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Different Perioperative Statin Regimens on the Protection Against Post Coronary Artery Bypass Grafting Major Adverse Cardio-cerebral Events
Status: COMPLETED
Conditions: Coronary Artery Bypass Grafting
Interventions: DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination of Intranasal Scopolamine and Sensory Augmentation to Mitigate G-transition Induced Motion Sickness and Enhance Sensorimotor Performance
Status: RECRUITING
Conditions: Motion Sickness, Space|Motion Sickness|Sea Sickness
Interventions: DRUG: DPI-386 Nasal Gel|DRUG: Placebo Nasal Gel|DRUG: DPI-386 Nasal Gel|DRUG: Placebo Nasal Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide and Gemcitabine as First-line Treatment in Patients With Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Carcinoma Metastatic|Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: Gemzar|DRUG: Revlimid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: R-3750 in Patients With Mild to Moderate Ulcerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis Chronic Mild|Ulcerative Colitis Chronic Moderate|Ulcerative Colitis Chronic|Ulcerative Colitis
Interventions: DRUG: R-3750
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Factorial Trial Testing Guided Thinking Tasks to Optimize a Physical Activity Intervention
Status: UNKNOWN
Conditions: Physical Inactivity
Interventions: BEHAVIORAL: Episodic future thinking|BEHAVIORAL: Positive affect imagery|BEHAVIORAL: Action planning|BEHAVIORAL: High dose|BEHAVIORAL: Recent thinking|BEHAVIORAL: Neutral imagery|BEHAVIORAL: Low dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability and Pharmacokinetics of Subcutaneous (SC) Injections of JNJ-64565111 in Healthy Male Japanese Participants and to Assess Pharmacokinetics Following Subcutaneous Injections of JNJ-64565111 in Healthy Male Caucasian Participants
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: JNJ-64565111|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Imaging of the Esophagus Using a SECM Capsule
Status: NOT_YET_RECRUITING
Conditions: Eosinophilic Esophagitis|Barrett Esophagus
Interventions: DEVICE: SECM capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effectiveness of Music on Pain and Anxiety in IUD Insertion
Status: UNKNOWN
Conditions: IUD Insertion Complication|Pain, Acute|Anxiety Acute
Interventions: BEHAVIORAL: Music listening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Thromboprophylaxis in Pregnant Women in Hospital: A Prospective Clinical Trial
Status: COMPLETED
Conditions: Thrombophilia Associated With Pregnancy|Perioperative/Postoperative Complications|Venous Thrombosis|Pulmonary Embolism|Other Specified Risk Factors in Pregnancy|Deep Vein Thrombosis
Interventions: DRUG: Enoxaparin|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION