pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Bimonthly VEGF Trap-Eye Compared to As-needed Administration or Other Therapy for Exudative Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Exudative Age-related Macular Degeneration
Interventions: DRUG: Intravitreal injection of Aflibercept
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Continuous Terlipressin Therapy After Endoscopic Variceal Ligation
Status: NOT_YET_RECRUITING
Conditions: Variceal Hemorrhage
Interventions: DRUG: Terlipressin|OTHER: 0.9% normal saline (NS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of BMS-813160 in Combination With Chemotherapy or Nivolumab in Participants With Advanced Solid Tumors
Status: COMPLETED
Conditions: Colorectal Cancer|Pancreatic Cancer
Interventions: DRUG: BMS-813160|BIOLOGICAL: Nivolumab|DRUG: Nab-paclitaxel|DRUG: Gemcitabine|DRUG: 5-fluorouracil (5-FU)|DRUG: Leucovorin|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TAK-648 Multiple-Rising Dose Study in Healthy Japanese Participants and Non-Japanese Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: TAK-648|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Technology-based Psychosocial Intervention to Support Social Engagement and Well-being in Older Adults With HIV
Status: NOT_YET_RECRUITING
Conditions: HIV Diagnosis
Interventions: BEHAVIORAL: COPPEhR Intervention|BEHAVIORAL: Device-only Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pentoxifylline/Nonalcoholic Steatohepatitis (NASH) Study: The Effect of Pentoxifylline on NASH
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis|Liver Diseases
Interventions: DRUG: Pentoxifylline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab Study With Carboplatin & Paclitaxel in Ovarian, Fallopian Tube or Primary Peritoneal Cancer
Status: TERMINATED
Conditions: Ovarian Cancer|Peritoneal Cancer|Fallopian Tube Cancer|Stage 3 Cancer|Stage 4 Cancer
Interventions: DRUG: Bevacizumab|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study of a New Medicine NNC0519-0130 in Japanese and Non-Japanese Men
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: NNC0519-0130|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized, CT-guided Antithrombotic Therapy Versus Lifelong Single Antiplatelet Therapy to Reduce Thromboembolic and Bleeding Events in Non-atrial Fibrillation Patients After Transcatheter Aortic Valve Implantation
Status: RECRUITING
Conditions: Severe Aortic Valve Stenosis
Interventions: RADIATION: CT guided strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiparametric PET-MRI Integration for a New Approach to Tumor Heterogeneity in Non-Small Cell Lung Cancer (NSCLC): Pilot Study
Status: UNKNOWN
Conditions: NSCLC
Interventions: DIAGNOSTIC_TEST: PET-MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of DPP-IV Inhibitor in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: DPP-IV Inhibitor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Combined Spinal Direct Current Stimulation on Upper Limb Recovery in Acquired Brain Injury
Status: TERMINATED
Conditions: Acquired Brain Injury
Interventions: DEVICE: tsDCS-Anodal Stimulation|DEVICE: tsDCS-Cathodal Stimulation|DEVICE: tsDCS-Sham Stimulation|DEVICE: Robotic-assisted training of arm and hand functions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ipilimumab (Immunotherapy) and MGN1703 (TLR Agonist) in Patients With Advanced Solid Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Cancers|Melanoma
Interventions: DRUG: MGN1703|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Sclerosis-Simvastatin Trial 2
Status: UNKNOWN
Conditions: Secondary Progressive Multiple Sclerosis (SPMS)
Interventions: DRUG: Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antibacterial Effect of Light-activated Calcium Silicate Versus Light-activated Calcium Hydroxide
Status: UNKNOWN
Conditions: Dental Caries Extending Into Dentin
Interventions: DRUG: TheraCal|DRUG: light-cured calcium hydroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Difference Between Daily and Alternative Day Use of Icodextrin
Status: NOT_YET_RECRUITING
Conditions: Peritoneal Dialysis Solution Adverse Reaction
Interventions: DRUG: Icodextrin Peritoneal Dialysis Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Anti-Sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: DRUG: Stannous fluoride toothpaste|DRUG: Regular fluoride toothpaste (Crest Cavity Protection)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MDR - PMCF Study for Echo FX Stem With RingLoc Bipolar Acetabular Cup and Femoral Head
Status: RECRUITING
Conditions: Hip Arthritis|Hip Disease|Hip Fractures|Hip Injuries|Hip Pain Chronic
Interventions: DEVICE: Echo FX Stem with RingLoc Bipolar Acetabular Cup and Femoral Head
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Clinical and Economic Impact of Pharmacogenomic Testing of Warfarin Therapy in Typical Community Practice Settings
Status: COMPLETED
Conditions: Embolism and Thrombosis|Embolism|Vascular Diseases|Warfarin|Venous Thromboembolism|Thrombosis|Thromboembolism
Interventions: OTHER: CYP 2C9 and VKORC1 Testing for Warfarin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Study Between Prader-Willi Patients Who Take Oxytocin Versus Placebo
Status: COMPLETED
Conditions: Prader Willi Syndrome
Interventions: DRUG: Syntocinon®/- Spray|DRUG: Physiological serum (Sodium chloride)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does Letrozole Improve Pregnancy Outcome in Fresh Embryo Transfer IVF/ICSI Cycle?
Status: UNKNOWN
Conditions: Investigative Techniques|Reproductive Techniques|Reproductive Techniques, Assisted
Interventions: DRUG: Letrozole 2.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: eRehab: Can Information and Communication Technology (ICT) Enhance Self-management of Cardiovascular Disease?
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: BEHAVIORAL: Tailored content|BEHAVIORAL: Generic Internet-based information|BEHAVIORAL: Discussion forum|BEHAVIORAL: Behavioral monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of LY01005 in Patients With Breast Cancer Compared to ZOLADEX®
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: LY01005|DRUG: ZOLADEX® 3.6 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Hydrocodone Bitartrate Extended-Release Tablets for Moderate to Severe Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: Hydrocodone ER|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physical Fitness, Exercise Self-efficacy, Physical Activity Level in People With Spinal Cord Injury (SCI)
Status: UNKNOWN
Conditions: Spinal Cord Injuries|Physical Disability
Interventions: OTHER: Graded Exercise Integrated Education|OTHER: Conventional Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Use of High-dose Proton Pump Inhibitor for the Treatment of Gastro-oesophageal Reflux Related Non-cardiac Chest Pain - a Randomized Double-blind Placebo-controlled Study
Status: UNKNOWN
Conditions: Chest Pain
Interventions: DRUG: Rabeprazole 20mg twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Rituximab Plus CHOP With Sargramostim in Patients With Newly Diagnosed Diffuse Large B-Cell Lymphoma
Status: COMPLETED
Conditions: Diffuse, Large B-Cell, Lymphoma
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Nitrous Oxide for Treatment-Resistant Depression: Optimizing Dosing Strategies
Status: COMPLETED
Conditions: Depressive Disorder, Major|Depressive Disorder, Treatment-Resistant
Interventions: DRUG: Nitrous Oxide 25%|DRUG: Nitrous Oxide 50%|DRUG: Placebo Gas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Convalescent Plasma (PC) and Human Intravenous Anti-COVID-19 Immunoglobulin (IV Anti COVID-19 IgG) in Patients Hospitalized for COVID-19.
Status: UNKNOWN
Conditions: Coronavirus Disease 2019 (COVID-19)
Interventions: BIOLOGICAL: COVID-19 convalescent plasma|BIOLOGICAL: Anti-COVID-19 human immunoglobulin|DRUG: Standard (specific) therapy for COVID-19
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Immunosuppression for Pediatric Crohn's Disease
Status: RECRUITING
Conditions: Crohn Disease|Infliximab|Immunosuppression|Children, Only
Interventions: DRUG: Infliximab and immunosuppressives|DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Effects of Subchronic Dopamine D2 Receptor Blockade by Antipsychotic Drugs in Healthy Humans
Status: COMPLETED
Conditions: Insulin Resistance|Dyslipidemia
Interventions: DRUG: olanzapine|DRUG: Haloperidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Safety Planning in Juvenile Justice for Suicidal Youth
Status: COMPLETED
Conditions: Suicidal Ideation|Suicide, Attempted|Nonsuicidal Self-injury
Interventions: BEHAVIORAL: Safety Planning|BEHAVIORAL: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketamine Versus Fentanyl for Induction of Anesthesia in Septic Shock
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: Ketamine|DRUG: Fentanyl|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Education vs. Self-management Associated With Movement Control Exercises for Chronic Low Back Pain
Status: UNKNOWN
Conditions: Chronic Low Back Pain
Interventions: OTHER: Pain Neuroscience Education|OTHER: Self-Management Education|OTHER: Movement Control Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Canned Beans of Multiple Varieties in Daily Amounts of 1 Cup and 1/2 Cup on Serum LDL Cholesterol and Other Cardiovascular Disease Risk Biomarkers in Adults With Elevated LDL Cholesterol
Status: COMPLETED
Conditions: Hypercholesterolemia|Cardiovascular Diseases
Interventions: DIETARY_SUPPLEMENT: Canned beans of multiple varieties|DIETARY_SUPPLEMENT: White Rice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sorafenib in Treating Patients With Metastatic or Unresectable Solid Tumors, Multiple Myeloma, or Non-Hodgkin's Lymphoma With or Without Impaired Liver or Kidney Function
Status: COMPLETED
Conditions: Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Refractory Multiple Myeloma|Splenic Marginal Zone Lymphoma|Stage II Multiple Myeloma|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Multiple Myeloma|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific|Waldenström Macroglobulinemia
Interventions: DRUG: sorafenib tosylate|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Phenylephrine During Shoulder Arthroscopic Surgery
Status: COMPLETED
Conditions: Disorder of Shoulder|Anesthesia
Interventions: DRUG: Phenylephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Together we Move: A Multi-component Intervention to Increase Physical Activity for Ethnic Minority Older Adults
Status: COMPLETED
Conditions: Physical Activity|Sedentary Lifestyle
Interventions: BEHAVIORAL: Self-Monitoring, peer support and motivational prompts|BEHAVIORAL: Self-monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Mild to Moderate Depression Symptoms in Patients With Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: DRUG: Venlafaxine HCl|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Simultaneous Tdap and IIV in Pregnant Women
Status: COMPLETED
Conditions: Pregnancy
Interventions: BIOLOGICAL: Tetanus, Diphtheria, and Pertussis Vaccine|BIOLOGICAL: 2016-2017 Quadrivalent Inactivated Influenza Vaccine|BIOLOGICAL: 2017-2018 Quadrivalent Inactivated Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CE Mark Study for the Harpoon Medical Device
Status: COMPLETED
Conditions: Mitral Valve Regurgitation|Mitral Valve Prolapse|Mitral Valve Insufficiency
Interventions: DEVICE: Harpoon Artificial ePTFE Chords
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comprehensive Wellness Program (SKY) to Mitigate Physician Burnout
Status: COMPLETED
Conditions: Depression|Anxiety|Stress|Insomnia|Optimism|Interpersonal Disengagement|Professional Fulfillment|Work Exhaustion|Self-reported Medical Errors|Physician Burnout
Interventions: BEHAVIORAL: Meditation and breathing program : Sudarshan Kriya Yoga (SKY)|BEHAVIORAL: Stress management education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PEA for the Relief of Chemotherapy-Induced Peripheral Neuropathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Chemotherapy-Induced Peripheral Neuropathy|Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: DRUG: Palmidrol|DRUG: Placebo Administration|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Prospective, Randomized Trial of BVS Veruss EES in Patients Undergoing Coronary Stenting for Myocardial Infarction
Status: UNKNOWN
Conditions: Cardiovascular Disease|Myocardial Infarction|Thrombus|Primary Angioplasty
Interventions: DEVICE: Bioresorbable vascular scaffold|DEVICE: Durable polymer everolimus-eluting metallic stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Hydroxyzine Decrease Anxiety in Underweight Patients Diagnosed With an Eating Disorder
Status: WITHDRAWN
Conditions: Anxiety in Those Patients With Anorexia Nervosa|Eating Disorder Not Otherwise Specified, BMI (<=18)
Interventions: DRUG: Hydroxyzine|DRUG: hydroxyzine HCL|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hypo Versus Conventional Fractionation in Reconstructed-Breast Cancer Mastectomy Patients
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Radiotherapy; Complications
Interventions: RADIATION: Hypofractionation|RADIATION: Conventional Fractionation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab Deruxtecan Alone or in Combination With Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer
Status: RECRUITING
Conditions: Early-stage Breast Cancer|Hormone Receptor Positive Breast Carcinoma|Invasive Breast Cancer|Stage II Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage III Breast Cancer
Interventions: DRUG: Anastrozole|PROCEDURE: Therapeutic Conventional Surgery|BIOLOGICAL: Trastuzumab Deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACT01 in Combination With Comp01-04 in Patients With Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: ACT01|DRUG: Comp01|DRUG: Comp02|DRUG: Comp03|DRUG: Comp04
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Construction and Effect Evaluation of Anticoagulation Management Model in Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: BEHAVIORAL: Standardized anticoagulation management plan and process of atrial fibrillation in primary medical institutions|BEHAVIORAL: Conventional general practitioner management model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Trial Comparing Dapaconazole Versus Miconazole in Patients With Tinea Cruris
Status: COMPLETED
Conditions: Tinea Cruris
Interventions: DRUG: Dapaconazole|DRUG: Miconazole Nitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone Irrigation of the Parotid Glands in Primary Sjögren's Syndrome Subjects
Status: TERMINATED
Conditions: Sjögren's Syndrome|Xerostomia
Interventions: DRUG: Dexamethasone Parotid Irrigation|DRUG: Placebo Parotid Irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Progestins in Treatment of Functional Ovarian Cyst
Status: UNKNOWN
Conditions: Functional Ovarian Cyst|Progesterone
Interventions: DRUG: Dydrogesterone 10 mg|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Everolimus Beyond Progression
Status: TERMINATED
Conditions: Estrogen Receptor-positive Breast Cancer|HER2-negative Breast Cancer|Progesterone Receptor-positive Breast Cancer|Recurrent Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: everolimus|DRUG: anastrozole|DRUG: letrozole|DRUG: tamoxifen citrate|DRUG: fulvestrant|DRUG: megestrol acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Implementation of EIT-4-BPSD
Status: COMPLETED
Conditions: Dementia|Behavioral and Psychological Symptoms of Dementia (BPSD)
Interventions: BEHAVIORAL: EIT-4-BPSD|BEHAVIORAL: Education-only Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigator Initiated Trial to Further Evaluate the Safety and Efficacy of Trans-perineal Focal Laser Ablation of Localized Prostate Cancer Using High Frequency Micro-ultrasound Imaging
Status: RECRUITING
Conditions: Prostate Cancer|Low-risk or Favorable Intermediate Risk Prostate Cancer Who Are on an Active Surveillance Regimen
Interventions: DEVICE: TRANBERG®|Thermal Therapy System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Tolerability and Pharmacokinetics of CKD-386(2) 80/20/10mg
Status: COMPLETED
Conditions: Hypertension and Dyslipidemia
Interventions: DRUG: CKD-386(2)|DRUG: D013, D326, D337
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trilaciclib (G1T28), a CDK 4/6 Inhibitor, in Combination With Etoposide and Carboplatin in Extensive Stage Small Cell Lung Cancer (SCLC)
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Carboplatin|DRUG: Placebo|DRUG: Trilaciclib|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Whole Body Vibration (WBV) on Spasticity in Poststroke Hemiplegia
Status: COMPLETED
Conditions: Muscle Spasticity|Physiology
Interventions: DEVICE: Sham vibrator|DEVICE: Real vibrator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Blended Intervention to Promote Physical Activity, Health and Work Productivity Among Office Employees
Status: COMPLETED
Conditions: Physically Well But Worried
Interventions: BEHAVIORAL: blended intervention|BEHAVIORAL: web-based intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: REinforcement of the Pancreas in distaL pAncreatectomY (REPLAY)
Status: COMPLETED
Conditions: Distal Pancreatectomy (DP)
Interventions: DEVICE: ENDO GIA X-tra Thick reload with Tri Staple Technology|DEVICE: ENDO GIA Articulating Reinforced Reload with Tri-Staple Technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of Psychotherapy Treatment of Children With Tics
Status: UNKNOWN
Conditions: Tic-Disorder
Interventions: BEHAVIORAL: Habit Reversal Training|BEHAVIORAL: Resources activation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of MICARDIS® (Telmisartan) on Blood Pressure Control and Quality of Live in Patients With Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Low dose of telmisartan|DRUG: High dose of telmisartan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prosthesis and Implant Survival in Immediately Loaded Temporary Full Arch Restorations
Status: UNKNOWN
Conditions: Completely Edentulous Patients
Interventions: PROCEDURE: Fiber-reinforced framework|PROCEDURE: No framework
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cells for the Treatment of COVID-19
Status: COMPLETED
Conditions: Covid19|Prophylaxis
Interventions: BIOLOGICAL: PrimePro|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Celecoxib in Preventing Cancer in Patients at High Risk for Ovarian Epithelial Cancer Who Are Undergoing Prophylactic Oophorectomy
Status: WITHDRAWN
Conditions: brca1 Mutation Carrier|brca2 Mutation Carrier|Ovarian Cancer
Interventions: DRUG: celecoxib|PROCEDURE: oophorectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of the Safety, Tolerability, and Bioactivity of Tocilizumab On Patients With Non-infectious UVEITIS: The STOP-UVEITIS Study
Status: UNKNOWN
Conditions: Intermediate Uveitis|Posterior Uveitis|Pan-uveitis
Interventions: DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chinese Herbal Fumigation With Acupuncture for the Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: OTHER: Fumigation|OTHER: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Follow up Study Designed to Obtain Long Term Data on Participants Who Either Achieved a Sustained Virologic Response or Did Not Achieve a Sustained Virologic Response in an AbbVie Sponsored Hepatitis C Study
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: ABT-450/ritonavir|DRUG: ABT-333|DRUG: ABT-267
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Etripamil in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Chinese Subjects
Interventions: DRUG: Etripamil Nasal Spray 70mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase I/II Study of WJ13404 Monotherapy in Patients With Advanced or Mentastatic Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Locally Advanced or Metastatic NSCLC
Interventions: DRUG: WJ13404 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Autologous Total Immunoglobulin G Therapy for Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: BIOLOGICAL: Autologous immunoglobulin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Veliparib and Temozolomide in Treating Patients With Acute Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1|Adult Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3); MLLT3-KMT2A|Adult Acute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2); PML-RARA|Adult B Acute Lymphoblastic Leukemia|Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|Adult T Acute Lymphoblastic Leukemia|Alkylating Agent-Related Acute Myeloid Leukemia|Chronic Myelomonocytic Leukemia|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Temozolomide|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flourish Vaginal Care System to Establish Neovaginal Microbiome
Status: ENROLLING_BY_INVITATION
Conditions: Neovaginal Microbiome
Interventions: DEVICE: Flourish Vaginal Care system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Interactive Tool to Support Self-management Through Lifestyle Feedback, Aimed at Physical Activity of COPD/DM Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Type 2 Diabetes
Interventions: DEVICE: Tool|BEHAVIORAL: Self-management Support Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial of Safety Nets In Hospitalized Patients
Status: COMPLETED
Conditions: Delirium|Agitated Behavior|Alcohol Withdrawl|Acute Confusional State|Acute Psychosis
Interventions: DEVICE: SOMA safe enclosure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: European Study of POBA Versus Cotavance(R) Paclitaxel Coated Balloon for the Treatment of Infrapopliteal Lesions in Critical Limb Ischemia (EURO CANAL)
Status: TERMINATED
Conditions: PAD|Infrapopliteal Lesions
Interventions: DEVICE: Cotavance Paclitaxel Coated Balloon|DEVICE: Standard balloon angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Trial of AMG 706 or Bevacizumab in Combination With Chemo for Advanced NSCLC
Status: TERMINATED
Conditions: Advanced Non-squamous NSCLC
Interventions: BIOLOGICAL: Bevacizumab|DRUG: AMG 706|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prognostic Value of Measuring CtDNA in a Cohort of Patients With Stage III and IV Upper Aero-digestive Tract (UADT) Cancer , Treated With Curative RADiOtherapy With or Without Concomitant Treatment.
Status: NOT_YET_RECRUITING
Conditions: SCC - Squamous Cell Carcinoma|Upper Aero-digestive Tract (UADT) Neoplasm
Interventions: OTHER: Blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Fexofenadine (Allegra®) in Healthy Adults Who Have Been Identified as Slow Metabolizers for Desloratadine
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Fexofenadine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Response to Zoster Vaccine in Adults With Inflammatory Bowel Disease Treated With Medications
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases|IBD
Interventions: BIOLOGICAL: Adjuvanted Recombinant Zoster Vaccine (RZV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART133
Status: COMPLETED
Conditions: Liver Cancer|Pancreatic Cancer|Brain Tumor|Breast Cancer|Ovarian Tumor|Colorectal Cancer|Acute Myeloid and Lymphoid Leukemias
Interventions: BIOLOGICAL: anti-CD133-CAR vector-transduced T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Acral Lentiginous Malignant Melanoma|Recurrent Melanoma|Stage IIIA Melanoma|Stage IIIB Melanoma|Stage IIIC Melanoma|Stage IV Melanoma
Interventions: DRUG: imatinib mesylate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ⅲ Clinical Trial With Oral Recombinant Helicobacter Pylori Vaccine in Chinese Children
Status: COMPLETED
Conditions: H. Pylori Infection
Interventions: BIOLOGICAL: H. pylori vaccine|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical, Prospective, Non-profit, Non-pharmacological Study on Geass Healing Abutment: Microbiological, Histological, and Immuno-histochemical Evaluation.
Status: COMPLETED
Conditions: Dental Implant Failed
Interventions: PROCEDURE: laser treated
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Permanent Internal Mammary Artery Occlusion in Stable Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease|Internal Mammary-Coronary Artery Anastomosis|Ischemia|Circulation, Collateral
Interventions: DEVICE: Amplatzer vascular plug 4|OTHER: Sham Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Pemetrexed-Based Induction Chemotherapy Followed by Concomitant Chemoradiotherapy in Previously Irradiated Head and Neck Cancer Patients
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: Gemcitabine|DRUG: Pemetrexed|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of a Combination of Plants to Regulate Mood
Status: RECRUITING
Conditions: Mood Regulation
Interventions: DIETARY_SUPPLEMENT: Saffron extract|DIETARY_SUPPLEMENT: Scutellaria baicalensis extract|DIETARY_SUPPLEMENT: Saffron and Scutellaria baicalensis extract|DIETARY_SUPPLEMENT: Placebo (maltodextrin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Chemical vs Electrical Cardioversion for Emergency Department Patients With Acute Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Electrical-first|DRUG: Chemical-first
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of Immune Globulin Intravenous (Human)IVIG-SN™ in Subjects With Primary Immunodeficiency
Status: COMPLETED
Conditions: Immunologic Deficiency Syndrome
Interventions: DRUG: Immune Globulin Intravenous (Human) 5% Liquid, IVIG-SN™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vancomycin Study: Treatment of Catheter Related Bloodstream Infection Caused by Coagulase Negative Staphylococcus
Status: COMPLETED
Conditions: Staphylococcal Infections
Interventions: DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Wumeiwan Jiawei Fang Use in Patients With Blepharospasm
Status: RECRUITING
Conditions: Dry Eye Syndromes|Meige Syndrome|Blepharospasm|Hyperactivity
Interventions: DRUG: Wumeiwan Jiawei Fang|DRUG: botulinum toxin A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cadonilimab Plus FOLFOXIRI and Bevacizumab as First Line Therapy for Metastatic MSS Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: cadonilimab|DRUG: irinotecan|DRUG: Oxaliplatin|DRUG: leucovorin or levoleucovorin|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacotoxicology of Trichloroethylene Metabolites
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Dichloroacetate environmental dose|DRUG: Chloral Hydrate environmental dose|DRUG: Dichloroacetate therapeutic dose|DRUG: Chloral Hydrate therapeutic dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Study for High Risk Multiple Myeloma Patients
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Elotuzumab|DRUG: Pomalidomide|DRUG: Carfilzomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Newly Diagnosed GBM With Temozolomide, Radiation, and Minocycline Followed by Adjuvant Minocycline/Temozolomide (D-TERMINED)
Status: COMPLETED
Conditions: Newly Diagnosed High Grade Glioma
Interventions: DRUG: Minocycline with chemoradiation (temozolomide and radiation therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Models of Screening, Brief Intervention With a Facilitated Referral to Treatment (SBIRT) for Opioid Patients in the Emergency Department
Status: COMPLETED
Conditions: Opiate Addiction
Interventions: BEHAVIORAL: Brief Negotiation Interview (BNI)|DRUG: Buprenorphine Initiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Study on Efficacy of Gemifloxacin-based Regimen for Helicobacter Pylori Infection
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Gemifloxacin-based triple therapy|DRUG: Standard triple therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Central Neuromuscular Dysfunction, Functionality, Psychological Status and Rotator Cuff Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Rotator Cuff Tears
Interventions: DIAGNOSTIC_TEST: Assessment of Central Neuromuscular Dysfunction, Shoulder Physical Functionality and Psychological Factors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Awake Thoracic Epidural Anaesthesia Versus General Anesthesia for Video Assisted Thoracoscopic Surgery
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: PROCEDURE: Thoracic epidural anaesthesia video assisted thoracoscopic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Coping-oriented Supportive Programme (COSP) for People With Spinal Cord Injury During Inpatient Rehabilitation
Status: UNKNOWN
Conditions: Spinal Cord Injury|Psychosocial Problem
Interventions: BEHAVIORAL: Experimental: Intervention group---coping-oriented supportive programme|BEHAVIORAL: Active Comparator: Comparison group---a didactic talk (usual care)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Single High Dose of Cholecalciferol on Serum Metabolites of Vitamin D
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DRUG: Cholecalciferol 120 000 IU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: HERTHENA-Lung02: A Study of Patritumab Deruxtecan Versus Platinum-based Chemotherapy in Metastatic or Locally Advanced EGFRm NSCLC After Failure of EGFR TKI Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Nonsquamous Non-small Cell Lung Cancer|EGFR L858R|EGFR Exon 19 Deletion
Interventions: DRUG: Patritumab Deruxtecan|DRUG: Platinum-based chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Imaging With ICG Registry
Status: COMPLETED
Conditions: Lung Nodule, Breast, Kidney,Parathyroid, Mediastinal, Skin Mass, Soft Tissue, Prostate, Stomach Pleural, Head and Neck, and Are at Risk of Recurrence
Interventions: OTHER: Registry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: HVTN Protocol 204 - A Phase II Clinical Trial to Evaluate the Safety and Immunogenicity of a Multiclade HIV-1 DNA Plasmid Vaccine, VRC-HIVDNA016-00-VP, Followed by a Multiclade Recombinant Adenoviral Vector HIV-1 Vaccine Boost, VRCHIVADV014-00-VP, in HIV-1 Uninfected Adult Participants
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: VRC-HIVDNA016-00-VP|BIOLOGICAL: VRC-HIVADV014-00-VP|BIOLOGICAL: VRC-HIVDNA016-00-VP placebo|BIOLOGICAL: VRC-HIVADV014-00-VP placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Benign/Malignant Pulmonary Nodule Classification Based on High-throughput Whole-genome Methylation Sequencing(GM-seq)
Status: RECRUITING
Conditions: Pulmonary Nodule, Solitary|Whole-genome Methylation Sequencing
Interventions: DIAGNOSTIC_TEST: Whole-genome Methylation Sequencing(GM-seq)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Compare the Effectiveness of Three Self-care Oral Hygiene Regimens
Status: COMPLETED
Conditions: Gingivitis
Interventions: DEVICE: Power device A|DEVICE: Power device B|DEVICE: Routine Oral Hygiene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Skin Autoflouresence Following Weight Loss and Maintenance Using Liraglutide in Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Liraglutide 3 mg (Saxenda)|DRUG: Liraglutide 3 mg placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AGA Biocellular Stem/Stromal Hair Regenerative Study
Status: ENROLLING_BY_INVITATION
Conditions: Hair Disease
Interventions: PROCEDURE: Intradermal Injection in hair loss|PROCEDURE: Platelet Rich Plasma|PROCEDURE: Adipose Derived Stem/Stromal Cells|PROCEDURE: Stem/Stromal Cellular Isolation (Digestive)|PROCEDURE: MatriStem Matrix (ACell) - Current Standard of Care|PROCEDURE: HD-PRP (High Density Platelet Rich Plasma)|PROCEDURE: Emulsified AD-tSVF|PROCEDURE: Emulsified AD-cSVF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Treatment of Ascites by the ALFApump System on Renal and Circulatory Function
Status: UNKNOWN
Conditions: Cirrhosis, Liver|Refractory Ascites
Interventions: DEVICE: ALFApump system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT