pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Dental Attire Effect on Children's Dental Anxiety
Status: COMPLETED
Conditions: Behavior, Child|Dental Anxiety|Anesthesia, Local
Interventions: BEHAVIORAL: Evaluation the effectiveness of distraction in the reception area in the management of anxious pediatric patients during dental local anesthesia|BEHAVIORAL: Evaluation the effectiveness of distraction in the treatment area in the management of anxious pediatric patients during dental local anesthesia|BEHAVIORAL: Evaluation the effectiveness of distraction in both reception and treatment areas in the management of anxious pediatric patients during dental local anesthesia|BEHAVIORAL: Evaluation of the effectiveness of basic behavior guidance techniques without using any type of distraction aids in the management of anxious pediatric patients during dental local anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MSM Product on Attenuating Nasal Provocation With a Standardized Allergenic Challenge
Status: COMPLETED
Conditions: Nasal Breathing
Interventions: DIETARY_SUPPLEMENT: MSM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigating the Effects of a Psycho-educational Support Group Therapy on Cancer Caregivers' Burden and Quality of Life
Status: UNKNOWN
Conditions: The Effect of a Psycho-education Support Group Therapy
Interventions: BEHAVIORAL: Psycho-educational support group therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Remineralization Potential of Pearl Powder Compared to CPP-ACP on Enamel White Spot Lesions
Status: UNKNOWN
Conditions: White Spot Lesion
Interventions: DRUG: Cpp-Acp|OTHER: Pearl powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuroprotectant for Hypertensive Intracerebral Hemorrhage
Status: UNKNOWN
Conditions: Intracerebral Hemorrhage
Interventions: DRUG: Placebos|DRUG: Cattle Encephalon Glycoside and Ignotin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Two Measures of Tactile Acuity in CRPS Type I Patients
Status: UNKNOWN
Conditions: CRPS Type I of the Upper Extremity|Neuropathy of the Median Nerve|Healthy Controls
Interventions: OTHER: Tactile acuity measured by 2PD and the GOT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluating the Burst Pressure of Simulated Bowel Anastomosis Constructed Using the Reverse Half-Hitch Alternating Post Knots
Status: COMPLETED
Conditions: Education, Medical|Surgery
Interventions: OTHER: Square Knot|OTHER: RHAP Knot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of Metoclopramide in Poor Ovarian Response IVF Patients
Status: UNKNOWN
Conditions: Poor Responders in IVF
Interventions: DRUG: Metoclopramide|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Children With Very High Risk Acute Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: filgrastim|DRUG: asparaginase|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: dexamethasone|DRUG: etoposide|DRUG: idarubicin|DRUG: leucovorin calcium|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: prednisone|DRUG: vincristine sulfate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Purposeful Exercises in Children Diagnosed With Special Learning Disabilities
Status: COMPLETED
Conditions: Lack of; Attention, With Hyperactivity (ADHD)|Specific Learning Disability
Interventions: OTHER: exercise|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Comparison of Skeletonized Versus Pedicled Left Internal Thoracic Artery
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: skeletonized harvesting technique|PROCEDURE: pedicled harvesting technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability of Cenicriviroc (CVC) in Combination With Truvada or Sustiva Plus Truvada in HIV 1-infected, Antiretroviral Treatment-naïve, Adult Patients Infected With Only CCR5-tropic Virus
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Cenicriviroc 100 mg|DRUG: Cenicriviroc 200 mg + Truvada|DRUG: Sustiva + Truvada
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Prevention of Postoperative Epidural Catheter Migration: a Comparison of Three Types of Dressing
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DEVICE: Tegaderm dressing|DEVICE: Epi-Fix dressing|DEVICE: Lockit-Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Therapeutic Effects of Maternal Melatonin Administration on Brain Injury and White Matter Disease
Status: TERMINATED
Conditions: Premature Birth
Interventions: DRUG: Melatonin 10 µg|DRUG: Melatonin 20 µg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Women With Resected Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: CMF regimen|DRUG: cyclophosphamide|DRUG: docetaxel|DRUG: epirubicin hydrochloride|DRUG: fluorouracil|DRUG: methotrexate|DRUG: tamoxifen citrate|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety Study of HepaStem for the Treatment of Urea Cycle Disorders (UCD) and Crigler-Najjar Syndrome (CN)
Status: COMPLETED
Conditions: Urea Cycle Disorders|Crigler Najjar Syndrome
Interventions: BIOLOGICAL: HepaStem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy, Radiotherapy and Bevacizumab in Patients With Unresectable Stage III Non-Small-Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DRUG: Bevacizumab|DRUG: Pemetrexed|PROCEDURE: Radiotherapy|OTHER: Folic Acid|OTHER: vitamin B12|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Three vs Twelve Months of Dual Anti-Platelet Therapy After Stent Implantation
Status: UNKNOWN
Conditions: Drug-Eluting Stents|Percutaneous Coronary Intervention
Interventions: DRUG: 3 months DAPT|DRUG: 12 months DAPT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Anti-PD-1 Combined With Albumin-Bound Paclitaxel in Patients With Recurrent Cervical Cancer
Status: UNKNOWN
Conditions: Recurrent Cervical Cancer
Interventions: DRUG: anti-PD-1+Albumin-Bound Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conduction System Stimulation to Avoid Left Ventricle Dysfunction
Status: COMPLETED
Conditions: Atrioventricular Block, Second and Third Degree|Pacemaker-Induced Cardiomyopathy|Heart Failure
Interventions: DEVICE: Pacemaker implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: D5611C00003 - Food Interaction Study With AZD1722 Tablet in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers Food Interaction Study
Interventions: DRUG: AZD1722 salt tablet|DRUG: AZD1722 free base tablet|DRUG: AZD1722 free base tablet + Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety Study of MC-1101 1% TID in the Treatment of Nonexudative Age-Related Macular Degeneration
Status: TERMINATED
Conditions: Nonexudative Age Related Macular Degeneration
Interventions: DRUG: MC-1101|DRUG: MC-1101 Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: KN026 in Combination With Chemotherapy in HER2 Positive Gastric Cancer Subjects Who Have Failed First-line Therapy
Status: RECRUITING
Conditions: Stomach Cancer
Interventions: DRUG: KN026/Placbo Injection|DRUG: Paclitaxel Injection|DRUG: Docetaxel Injection|DRUG: Irinotecan Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy, of Early Versus Late Use of Vedolizumab in Crohn's Disease: the LOVE-CD Study
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DRUG: vedolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide Plus Cyclosporine in Treatment-Naive Severe Aplastic Anemia
Status: COMPLETED
Conditions: Aplastic Anemia|Neutropenia|Pancytopenia|Severe Aplastic Anemia
Interventions: DRUG: Cyclophosphamide|DRUG: Cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iron Absorption and Variations of Iron Status, Hepcidin, Inflammation and Sex Hormones During the Menstrual Cycle
Status: COMPLETED
Conditions: Iron-deficiency
Interventions: OTHER: Test meal labelled with 54Fe|OTHER: Test meal labelled with 57Fe|OTHER: Test meal labelled with 58Fe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Whole Body Vibration With Plyometric Training on Physical Performance in Basketball Players
Status: COMPLETED
Conditions: Muscle Strength|Postural Balance|Range of Motion, Articular|Walking Speed, Mesh id D000072797
Interventions: OTHER: whole body vibration|OTHER: plyometric training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analysis of DNA Methylation in Spondyloarthritis
Status: COMPLETED
Conditions: Spondylitis, Ankylosing|Axial Spondyloarthritis|DNA Methylation
Interventions: OTHER: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Exploratory Study To Assess the Efficacy and Safety of a Triple Combination for Acute Pain Treatment in Patients With Temporomandibular Joint Disorders (TMJD).
Status: COMPLETED
Conditions: Temporomandibular Joint Disorders
Interventions: DRUG: Ibuprofen|DRUG: Magnesium|DRUG: Ascorbic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Trial of Recombinant-Methionyl Human Stem Cell Factor (SCF) in Adult Patients With Sickling Disorders
Status: COMPLETED
Conditions: Hemoglobin SC Disease|Sickle Cell Anemia
Interventions: DRUG: Recombinant-methionyl human stem cell factor
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: KEYMAKER-U01 Substudy 2: Efficacy and Safety Study of Pembrolizumab (MK-3475) When Used With Investigational Agents in Treatment-naïve Participants With Anti-programmed Cell Death Receptor Ligand 1 (PD-L1) Positive Advanced Non-small Cell Lung Cancer (NSCLC) (MK-3475-01B/KEYMAKER-U01B)
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: BIOLOGICAL: Pembrolizumab|BIOLOGICAL: MK-4830|BIOLOGICAL: MK-0482
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Severe Neutropenia After HIPEC Using Mitomycin-C
Status: COMPLETED
Conditions: Colorectal Cancer Metastatic|Cancer Metastatic to the Peritoneal Cavity|Appendiceal Neoplasm|Pseudomyxoma Peritonei
Interventions: PROCEDURE: Intraoperative blood and peritoneal fluid samplings during HIPEC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Role of Nintendo Wii in Improving Negative Symptoms and Quality of Life in Chronic Schizophrenia
Status: COMPLETED
Conditions: Chronic Schizophrenia
Interventions: OTHER: Nintendo Wii video console and Nintendo Wii Fit Plus games
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Immunosuppressants in Renal Transplant Candidates Who Have Undergone Laparoscopic Sleeve Gastrectomy
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DRUG: Astagraf XL|DRUG: Prograf|DRUG: Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: SPL026 (DMT Fumarate) in Healthy Subjects and MDD Patients
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: SPL026|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Correlation Between NOL Index After Stimulus and Post-operative Opioid, Pain, Pre-operative Phenotype
Status: TERMINATED
Conditions: Pain, Postoperative|Anesthesia|Catastrophizing|Nociceptive Pain
Interventions: DEVICE: Standardized tetanic stimulation|DIAGNOSTIC_TEST: Catastrophizing score|DIAGNOSTIC_TEST: Nociceptive threshold|BIOLOGICAL: Biomarkers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study Evaluating the Safety and Efficacy of Gemtuzumab Ozogamicin in Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Gemtuzumab Ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Validity and Security of Reh-acteoside Therapy for Patients of IgA Nephropathy
Status: UNKNOWN
Conditions: IGA Nephropathy
Interventions: DRUG: Prednisolone|DRUG: Reh-acteoside
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feeding Tolerance and Gut Maturation of Infants Consuming a Formula Rich in Glycoprotein
Status: COMPLETED
Conditions: Digestion|Gut Microbiota
Interventions: DIETARY_SUPPLEMENT: Commercially Available Starter Infant Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Turkish Version of The Measure of Processes of Care (MPOC)
Status: UNKNOWN
Conditions: Cerebral Palsy|Muscular Dystrophies|Autism Spectrum Disorder|Traumatic Brain Injury|Down Syndrome|Disability, Developmental|Disability Physical
Interventions: OTHER: Participation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess the Efficacy, Safety, and Tolerability of SAR440340/REGN3500/Itepekimab in Chronic Obstructive Pulmonary Disease (COPD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Itepekimab SAR440340|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY900014 Formulation at Different Injection Sites in Healthy Participants
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: LY900014 (SC)|DRUG: LY900014 (IV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Glucose:Fructose Versus Glucose Carbohydrate Ingestion and Endurance Performance
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Mixture of glucose and fructose|DIETARY_SUPPLEMENT: glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Frequent, Low-Dose Erythropoietin A Mechanistic Approach to Mitigate Adverse Cardiovascular Effects of Erythropoietin
Status: TERMINATED
Conditions: Anemia|CKD|Atherosclerosis|Cardiovascular
Interventions: DRUG: Low dose erythropoietin|DRUG: High dose erythropoietin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Adverse Side Effects of Two Forms of Iron in Pregnancy
Status: RECRUITING
Conditions: Pregnancy|Iron Deficiency
Interventions: DIETARY_SUPPLEMENT: Ferrous fumarate|DIETARY_SUPPLEMENT: Ferrous bisglycinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Risperidone Treatment for Military Service Related Chronic Post Traumatic Stress Disorder
Status: COMPLETED
Conditions: Stress Disorders|Post-Traumatic
Interventions: DRUG: Risperidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Universal Endometrial Cancer DNA Sequencing for Detection of Lynch Syndrome and Personalized Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Adenocarcinoma|Endometrial Carcinoma|Lynch Syndrome|Relatives
Interventions: OTHER: Genetic Counseling|OTHER: Genetic Testing|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Mutation Carrier Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: OCT Screening for Diabetic Macular Edema at Primary Diabetes Care Visits
Status: COMPLETED
Conditions: Diabetes|Diabetic Macular Edema|Diabetic Retinopathy
Interventions: DEVICE: OCT imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Shockwave Therapy (SWT)
Status: COMPLETED
Conditions: Gynoid Lipodystrophy
Interventions: DEVICE: Shockwave therapy|OTHER: Aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OSI-774 (Tarceva) Plus Gemcitabine in Patients With Locally Advanced, Unresectable or Metastatic Pancreatic Cancer.
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Tarceva (erlotinib HCl, OSI-774)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Pressures During Non-invasive Ventilation Utilizing NIV Plus Software
Status: NOT_YET_RECRUITING
Conditions: Respiratory Distress Syndrome, Newborn|Apnea of Newborn
Interventions: DEVICE: NIV plus software
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-operative Feed Back on Traction Force During Vacuum Extraction: Safe Vacuum Extraction Alliance
Status: COMPLETED
Conditions: Hypoxic Ischemic Encephalopathy|Neonatal Convulsions|Subgaleal Hematoma
Interventions: DEVICE: Vacuum extraction intelligent system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Helium-oxygen Gas Mixtures Delivered by a High Flow Nasal Cannula in Bronchiolitis
Status: TERMINATED
Conditions: Bronchiolitis|Heliox|Pediatrics
Interventions: DEVICE: Vapotherm-Heliox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Dasatinib, Cetuximab and Radiation With or Without Cisplatin in HNSCC
Status: TERMINATED
Conditions: Head and Neck Cancer
Interventions: DRUG: Cetuximab|DRUG: Dasatinib|DRUG: Cisplatin|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Retreatment With MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis (RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: rituximab [MabThera/Rituxan]|DRUG: rituximab [MabThera/Rituxan]|DRUG: rituximab [MabThera/Rituxan]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Study With GLPG3667 and Itraconazole in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG3667|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prediction of Dietary Intervention Efficacy in Mild Ulcerative Colitis Patients Based on Fecal Microbiome Signatures
Status: NOT_YET_RECRUITING
Conditions: Ulcerative Colitis
Interventions: DIETARY_SUPPLEMENT: Prebiotics|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of VX-950, Pegasys and Copegus in Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: VX-950|DRUG: ribavirin|DRUG: peginterferon alfa-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Study of PEP503 With Radiotherapy in Combination With Concurrent Chemotherapy for Patients With Head and Neck Cancer
Status: TERMINATED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: PEP503|DRUG: Cisplatin|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Nurse-Administered Propofol Sedation and Diazemuls / Pethidine in Outpatient Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: diazemuls, pethidine|DRUG: Propofol and Alfentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Web-Based Intervention for Binge Eating Disorder
Status: COMPLETED
Conditions: Binge Eating Disorder
Interventions: OTHER: Selfapy for Binge Eating Disorder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain, Sleep and Gut Microbiota
Status: RECRUITING
Conditions: Sensitization, Central|Peripheral Sensitization|Gut Microbiota|Sleep Quality
Interventions: OTHER: Screening visit|OTHER: Peripheral sensitization session|OTHER: Central sensitization session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Endogenous Modulation of Pain and Stretch Tolerance
Status: COMPLETED
Conditions: Pain Threshold
Interventions: OTHER: Exercise induced hypoalgesia (EIH)|OTHER: Static stretch (SS)|OTHER: Rest|OTHER: Conditioned pain modulation (CPM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dosing Study of Remifentanil for Smooth Removal of the Laryngeal Mask Airway (LMA)
Status: COMPLETED
Conditions: Drug Usage
Interventions: DRUG: remifentanil|DEVICE: laryngeal mask airway (LMA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction Study Between EDP-938, Cyclosporine and Prednisone in Healthy Adult Subjects
Status: COMPLETED
Conditions: RSV Infection
Interventions: DRUG: EDP-938|DRUG: EDP-938|DRUG: Cyclosporine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Demonstrate the Relative Bioequivalence of Cefdinir and Omnicel 250 mg/5 ml Oral Suspension Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cefdinir 250 mg/5 ml Suspension (Sandoz, Austria)|DRUG: Omnicef Cefdinir 250 mg/5 ml Suspension (Abbott Laboratories, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double Blind Study of Vigabatrin for the Treatment of Cocaine Dependence
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: Vigabatrin|DRUG: Placebo|BEHAVIORAL: Group therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety of Myozyme® and of Aldurazyme® in Male and Female Participants of Any Age Group With Pompe Disease or With Mucopolysaccharidosis Type I (MPS I) in a Home-care Setting
Status: COMPLETED
Conditions: Pompe Disease|Mucopolysaccharidosis Type I (MPS I)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety on SOM3355 in Huntington's Disease Chorea
Status: ACTIVE_NOT_RECRUITING
Conditions: Huntington Chorea
Interventions: DRUG: SOM3355 capsules|DRUG: Placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Bluetooth Home Blood Pressure Monitors With Pharmacist Interventions
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: Telehealth Follow-up Visits|BEHAVIORAL: Surveys|DEVICE: Devices
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Doxorubicin Beads in Treating Patients With Unresectable Liver Metastases From Neuroendocrine Tumors
Status: TERMINATED
Conditions: Gastrointestinal Carcinoid Tumor|Islet Cell Tumor|Metastatic Cancer
Interventions: DRUG: PVA microporous hydrospheres/doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Progesterone Administration on Drug-Induced QT Interval Lengthening
Status: COMPLETED
Conditions: Prolonged QT Interval in EKG and Sudden Death
Interventions: DRUG: Progesterone|DRUG: Placebo|DRUG: Ibutilide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Amiodarone for the Prevention of Reperfusion Ventricular Fibrillation
Status: COMPLETED
Conditions: Other Intraoperative Cardiac Functional Disturbances During Cardiac Surgery
Interventions: DRUG: Lidocaine|DRUG: Amiodarone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Role of Circulating Tumor DNA in Predicting the Likelihood of Organ Preservation After Clinical Complete Response to Neoadjuvant Therapy for Rectal Cancer
Status: WITHDRAWN
Conditions: Gastrointestinal Malignancies
Interventions: OTHER: The Functional Assessment of Cancer Therapy- Colorectal
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pegaptanib Sodium Compared to Sham Injection in Patients With Recent Vision Loss Due to Macular Edema Secondary to Central Retinal Vein Occlusion (CRVO)
Status: COMPLETED
Conditions: Retinal Vein Occlusion
Interventions: DRUG: pegaptanib sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate Safety, Tolerability and Pharmacokinetics of SV001 in Chinese Healthy Adult Volunteers.
Status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: SV001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Argon Plasma Coagulation vs Hemoclipping for Bleeding Peptic Ulcers
Status: COMPLETED
Conditions: Bleeding Peptic Ulcer
Interventions: DEVICE: argon plasma coagulation|DEVICE: hemoclipping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correlation of Intravascular Injection Rate and Severity of Cervical Neural Foraminal Stenosis
Status: UNKNOWN
Conditions: Analgesia, Epidural
Interventions: PROCEDURE: Cervical transforaminal epidural steroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Liposomal Bupivacaine Interscalene Nerve Block in Shoulder Arthroplasty
Status: COMPLETED
Conditions: Arthropathy Shoulder
Interventions: DRUG: Liposomal Bupivacaine|DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Comparison of Radiological Exposure With TRIPTable® in Patients With Acute Coronary Syndromes
Status: UNKNOWN
Conditions: Acute Coronary Syndromes|Angioplasty, Transluminal, Percutaneous Coronary
Interventions: DEVICE: TripTable|DEVICE: Radial|DEVICE: Femoral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anterior Cruciate Ligament-reconstruction: Quadriceps Tendon or Hamstrings Tendon? A Prospective Trial
Status: COMPLETED
Conditions: Ligament; Laxity, Knee|Rupture of Anterior Cruciate Ligament
Interventions: PROCEDURE: Quadriceps graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study the Effect of Probiotic Supplementation on Trimethylamine-N-Oxide Plasma Level in Hemodialysis Patients
Status: ENROLLING_BY_INVITATION
Conditions: End Stage Renal Disease
Interventions: DIETARY_SUPPLEMENT: Lactobacillus containing probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Application of Daptomycin in MRSA Infected Diabetic Foot in Comparison to Vancomycin Treatment
Status: TERMINATED
Conditions: Diabetic Foot
Interventions: DRUG: Daptomycin|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BL-M17D1 in Patients With Locally Advanced or Metastatic HER2 Positive/Negative Breast Cancer and Other Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Solid Tumor
Interventions: DRUG: BL-M17D1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I, Open Label, Non Randomized, Multicenter, Dose Escalation Clinical Study to Investigate Safety and Tolerability of OPB(Otsuka Pharmaceutical Biwa)-111077 in Subjects With Advanced HCC(Hepatocellular Carcinoma)
Status: TERMINATED
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DRUG: OPB-111077
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single Ascending Dose and Multiple Doses With Titration of TAK-935 in Healthy Japanese Participants
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: TAK-935|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Pinless Navigation and Conventional Method in Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Primary total knee replacement by pinless navigation (Orthomap Express,Stryker, Michigan)|PROCEDURE: Primary total knee replacement by traditional jig and minimally invasive technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Activity Study of Intrathecally Administered Ziconotide for Neuropathic Pain in Patients With Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain|Neuropathic Pain|Intractable Pain|Cancer
Interventions: DRUG: ziconotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing the Kinetics of Endothelial Cell Loss Associated With the XEN® Implant Versus Traditional Filtering Surgery for Glaucoma
Status: WITHDRAWN
Conditions: Glaucoma
Interventions: DEVICE: measurement of endothelial cell density by specular microscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Effectiveness of Juvéderm® VOLIFT®™ With Lidocaine for Dynamic Radial Cheek Line Skin Depressions
Status: COMPLETED
Conditions: Cheek Line Depressions
Interventions: DEVICE: Juvéderm® VOLIFT®™ with Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of AZD2281 in Patients With Known BRCA Mutation Status or Recurrent High Grade Ovarian Cancer or Patients With Known BRCA Mutation Status/ Triple Neg Breast Cancer
Status: COMPLETED
Conditions: Ovarian Carcinoma|Breast Cancer
Interventions: DRUG: AZD2281
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Goal Focused, Non-Pharmacological Treatment for Persons With ADHD/ADD.
Status: COMPLETED
Conditions: Attention-Deficit Hyperactivity Disorder, Unspecified Type
Interventions: BEHAVIORAL: Goal Attainment Scaling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Electroacupuncture on Mixed Urinary Incontinence Among Women
Status: UNKNOWN
Conditions: Urinary Incontinence, Mixed
Interventions: OTHER: electroacupuncture|OTHER: sham electroacupuncture|BEHAVIORAL: life style counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selective Estrogen Receptor Modulators (SERMs) - A Potential Treatment for Psychotic Symptoms of Schizophrenia in Men?
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder
Interventions: DRUG: Raloxifene Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Patient Management Based on Continuous Continuous Glucose Monitoring on Major Adverse Cardiovascular Events in Patients With Type 2 Diabetes and Moderate to Severe Coronary Artery Stenosis
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2|Major Adverse Cardiac Events
Interventions: DEVICE: CGM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Ischemic Postconditioning on MicroRNAs in Double Valve Replacement
Status: UNKNOWN
Conditions: Cardiopulmonary Bypass|Ischemic Postconditioning
Interventions: PROCEDURE: ischemic postconditioning|PROCEDURE: double valve replacement|DEVICE: heart-lung machine|DEVICE: Aortic cross-clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Short Term Outcome of Laparoscopic Trans-abdominal Preperitoneal Inguinal Hernia Repair Without Mesh Fixation
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: PROCEDURE: fixation of mesh prosthesis|PROCEDURE: mesh placement without fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Role of Tegaserod Therapy in the Management of Gastroesophageal Reflux Disease (GERD) Symptoms in Patients With Incomplete Response to Proton Pump Inhibitors (PPIs).
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease (GERD)
Interventions: DRUG: Tegaserod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Dabigatran's Effect on Changes in Atrial Fibrosis in Patients With Atrial Fibrillation
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: DRUG: Dabigatran etexilate (Pradaxa)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Systemic Lidocaine Versus Ultrasound-guided Adductor Canal Block for Patients Undergoing Total Knee Arthroplasty
Status: RECRUITING
Conditions: Arthroplasty, Replacement, Knee|Total Knee Arthroplasty
Interventions: DRUG: Lidocaine IV|DRUG: Saline IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: DS-1205c With Osimertinib for Metastatic or Unresectable Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: DRUG: DS-1205c|DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrophysiological Effects of Tipranavir Co-administered With Ritonavir on the QT Interval in Healthy Female and Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: TPV low|DRUG: Placebo|DRUG: Moxifloxacin|DRUG: TPV high|DRUG: RTV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Airway Management in Morbidly Obese Patients: A Comparison of Intubating Laryngeal Mask Fastrack and Air Q as a Conduit for Fiberoptic Intubation
Status: COMPLETED
Conditions: Intubation; Difficult or Failed
Interventions: DEVICE: Air-Q. ILA insertion of proper size|DEVICE: ILMA insertion of proper size
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dose-Finding Study Comparing the Safety and Efficacy of Latanoprost to a Novel Treatment for Glaucoma
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma|Ocular Hypertension|Pigmentary Glaucoma|Pseudoexfoliative Glaucoma
Interventions: DRUG: PF-03187207 and Latanoprost Vehicle|DRUG: Latanoprost 0.005% and PF-03187207 Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Treatment of Soft Tissue Sarcoma With First-line Chemotherapy Failure by Anrotenil Hydrochloride Capsule
Status: COMPLETED
Conditions: Soft Tissue Sarcomas
Interventions: DRUG: Anlotinib Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of Clinical, Endoscopic and Histopathological Features of Colitis in Children
Status: NOT_YET_RECRUITING
Conditions: Role of Ileoscopy in Diagnosis of Colitis
Interventions: DEVICE: Colonoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Fludeoxyglucose F18 Positron Emission Tomography Imaging In Assessing Patients Before and After Treatment for Locally Advanced Non-Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: cisplatin|DRUG: docetaxel|DRUG: etoposide|DRUG: paclitaxel|DRUG: vinblastine sulfate|DRUG: vinorelbine tartrate|GENETIC: gene expression analysis|PROCEDURE: positron emission tomography|RADIATION: fludeoxyglucose F 18|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neoadjuvant Response-guided Treatment of Slowly Proliferating Hormone Receptor Positive Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Early-Stage Breast Carcinoma|Hormone Receptor Positive Tumor
Interventions: DRUG: Tamoxifen or Aromatase Inhibitor or Aromatase Inhibitor + goserelin|DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of SRT as Salvage Therapy in Patients With Brain Oligo-progression of EGFR-mutant Non-small Cell Lung Cancer After Failure of the Third-generation EGFR-TKIs
Status: RECRUITING
Conditions: Lung Cancer Stage IV
Interventions: DRUG: Aumolertinib Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Physical Activity Provide Additional Benefit In Patients With Rotator Cuff Related Shoulder Pain?
Status: COMPLETED
Conditions: Rotator Cuff Injuries
Interventions: PROCEDURE: exercise program consisting of supervised exercise and physical activity|PROCEDURE: exercise program consisting of only supervised exercises.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Zirconium Dioxide Fixed Dental Prosthesis.
Status: COMPLETED
Conditions: Missing Teeth
Interventions: PROCEDURE: Fixed dental prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Prospective Surveillance and Early Physical Therapy for Trismus
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Cancer|Trismus
Interventions: BEHAVIORAL: Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Exploring the Effectiveness of Group Cognitive Stimulation Therapy in People With Schizophrenia.
Status: UNKNOWN
Conditions: Cognitive Therapy
Interventions: OTHER: group cognitive stimulation therapy|OTHER: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Monoclonal Antibody Therapy and Docetaxel in Treating Women With Metastatic or Recurrent Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: cBR96-doxorubicin immunoconjugate|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Powered Surgical Stapler in VATS Lung Resection Procedures in China
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DEVICE: Echelon Flex™ 45 and 60 Powered ENDOPATH® Stapler Articulating Endoscopic Linear Cutter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of 2 Synthetic Nitrile Male Condoms Compared to a Standard Latex Male Condom
Status: COMPLETED
Conditions: Sexually Transmitted Diseases
Interventions: DEVICE: Synthetic Nitrile Condoms (53mm)|DEVICE: Synthetic Nitrile Condoms (56mm)|DEVICE: Control Latex Condom
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Identification of Herpes Simplex Virus (HSV) Shedding in the Female Genital Tract of Pregnant and Nonpregnant Women by GeneXpert PCR, Routine PCR, and Culture
Status: COMPLETED
Conditions: Herpes Simplex Virus
Interventions: DEVICE: Genexpert assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p