pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Adebrelimab Plus Apatinib for Maintenance Therapy of Extensive Small Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Adebrelimab Injection|DRUG: Apatinib Mesylate Tablets|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Roxadustat in the Treatment of Acute Myocardial Infarction
Status: UNKNOWN
Conditions: ST Elevation Myocardial Infarction
Interventions: DRUG: Roxadustat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Glucose Monitors to Regulate Glucose Levels in Type 2 Diabetics
Status: COMPLETED
Conditions: Type2 Diabetes
Interventions: DEVICE: Continuous Glucose Monitor (CGM)|DEVICE: Activity Tracker|BEHAVIORAL: Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Impact of Oral Glutathione on Oxidative Damage and Glycated Hemoglobin (HbA1c) Levels in Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: enhanced glutathione|OTHER: placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple-Dose, Dose-Escalation Safety, Pharmacodynamics, and Pharmacokinetics Study of Imprime PGG™ Injection
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Imprime PGG TM for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Transcranial Direct Current Stimulation (TDCS) for Auditory Hallucinations in Early Onset Schizophrenia (EOS)
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DEVICE: Intervention Active tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Elastography Assessment of Spleen and Liver Stiffness Before and After Transjugular Intrahepatic Portosystemic Shunt (TIPS) Procedure
Status: COMPLETED
Conditions: Portal Hypertension
Interventions: PROCEDURE: Transjugular Intrahepatic Portosystemic Shunt
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bright Light: An Adjunct Treatment for Combat Posttraumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: OTHER: Bright Light Exposure|OTHER: Negative Ion Generator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial Studying Chemotherapy in Nigerian Women With Triple Negative Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Cyclophosphamide|DRUG: Epirubicin|DRUG: Docetaxel|DRUG: Carboplatin|PROCEDURE: Breast Surgery|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Mipomersen in Patients With Severe Hypercholesterolemia on a Maximally Tolerated Lipid-Lowering Regimen and Who Are Not on Apheresis
Status: COMPLETED
Conditions: Hypercholesterolemia|Coronary Heart Disease
Interventions: DRUG: Mipomersen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Effect of Food and a Proton Pump Inhibitor on Selpercatinib (LY3527723) in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Selpercatinib|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study on Single and Multiple Atomization Inhalation of HRS-9821 Suspension for Inhalation in Healthy Subjects
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: HRS-9821|DRUG: HRS-9821
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Parenting Intervention: Bio-behavioral Outcomes in Infants With Neurodevelopmental Disabilities
Status: COMPLETED
Conditions: Epigenomics|Developmental Disability|Early Intervention|Parent-Child Relations
Interventions: BEHAVIORAL: Video-Feedback Intervention|OTHER: Phone-Call Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Peripheral Neurostimulation for Nerve Block Placement
Status: NOT_YET_RECRUITING
Conditions: Pain Syndrome
Interventions: DEVICE: B Braun HNS 12 nerve stimulator|DEVICE: B Braun HNS 12 nerve stimulator sham control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Apatinib Plus Camrelizumab in Patients With Previously Treated Advanced Biliary Tract Cancer
Status: COMPLETED
Conditions: Biliary Tract Cancer|Cholangiocarcinoma|Biomarker|Hepatobiliary Neoplasm
Interventions: DRUG: Apatinib plus Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Journey Bicruciate Stabilized (BCS) Design and Legion Posterior Stabilized (PS) Design; Comparative Study
Status: RECRUITING
Conditions: Primary Total Knee Arthroplasty
Interventions: OTHER: Follow-up of BCR TKA|OTHER: Follow-up of BCS TKA|OTHER: Follow-up of PS TKA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Intravenous Versus Intracoronary Use of Abciximab
Status: COMPLETED
Conditions: Atherosclerosis|Ischemic Heart Disease
Interventions: DRUG: Abciximab|DRUG: Abciximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BroadBand Light for the Treatment of Dry Eye Disease
Status: NOT_YET_RECRUITING
Conditions: Dry Eye Syndromes|Meibomian Gland Dysfunction
Interventions: DEVICE: Broadband Light treatment|DEVICE: Sham broadband light treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Intrauterine Administration of Autologous PBMC on the Endometrial Cells Populations
Status: RECRUITING
Conditions: Female Infertility
Interventions: BIOLOGICAL: Intrauterine administration of autologous peripheral blood mononuclear cells (PBMC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment Of The Effects Of Single Doses Of An Investigational Drug, Given Alone Or With Donepezil, On Scopolamine-Induced Changes In Memory And Learning In Healthy Adults
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: Scopolamine + Donepezil Placebo + PF-04995274 Placebo|DRUG: Scopolamine + Donepezil 5 mg + PF-04995274 Placebo|DRUG: Scopolamine + Donepezil 10mg + PF-04995274 Placebo|DRUG: Scopolamine + Donepezil Placebo + PF-04995274 0.25 mg|DRUG: Scopolamine + Donepezil Placebo + PF-04995274 15 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Preliminary Results for the Double-dose Adenovirus-mediated Adjuvant Therapy Improving Outcome of Liver Transplantation in Patients With Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Liver Cancer|Hepatocellular Carcinoma
Interventions: PROCEDURE: LT|DRUG: ADV-TK|DRUG: ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension Study to VEG105192 to Assess Pazopanib in Patients With Advanced/Metastatic Renal Cell Cancer
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Upper Airway Anatomy, Quality of Life Measures, and Polysomnographic Parameters Using A Functional Dental Appliance
Status: WITHDRAWN
Conditions: Obstructive Sleep Apnea|Malocclusion
Interventions: DEVICE: Homeoblock
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Persistence of the Immune Response to Hepatitis B in 7-9 Years Old Children Previously Vaccinated With DTPa-HBV-IPV/Hib
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: hepatitis B vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate ASP0367 in Participants With Mild/Moderate Hepatic Impairment Compared to Participants With Normal Hepatic Function
Status: COMPLETED
Conditions: Hepatic Impairment|Healthy Volunteers
Interventions: DRUG: Bocidelpar
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinnova-MS: A Prospective Cohort Study of Patients With Multiple Sclerosis (Switzerland)
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis|Multiple Sclerosis, Relapsing-Remitting|Multiple Sclerosis, Primary Progressive|Multiple Sclerosis, Secondary Progressive
Interventions: OTHER: All participants will be asked to provide data and samples for collection and analysis.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate Safety and Efficacy of Carrimycin for Treatment of Severe Coronavirus Disease 2019 (COVID-19) in Hospitalized Patients
Status: TERMINATED
Conditions: Coronavirus Disease 2019
Interventions: DRUG: Carrimycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Gefitinib Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Bioequivalence Study
Interventions: DRUG: Gefitinib Tablet 250mg of Hunan Kelun|DRUG: Iressa® Tablet 250mg of AZN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Conventional Microneedling vs Microneedling With 5-FU (MMP) for Idiopathic Guttate Hypomelanosis (IGH) Repigmentation
Status: UNKNOWN
Conditions: Photosensitivity Disorders
Interventions: DRUG: MMP with 5-FU|DRUG: MMP with Saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy of Radial Artery Catheterization in Three Different Regions in Intensive Care Patients
Status: COMPLETED
Conditions: Arterial Cannulation in Intensive Care Unit|Catheterization, Peripheral|Radial Artery
Interventions: PROCEDURE: The radial artery cannulation over 2 cm of the wrist|PROCEDURE: The radial artery cannulation in the distal 3/4 area of the forearm|PROCEDURE: The radial artery cannulation in the distal 1/2 area of the forearm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase II Study Bolstering Outcomes by Optimizing Immunotherapy Strategies With Evolocumab and Nivolumab in Patients With Metastatic Renal Cell Carcinoma (BOOST-RCC)
Status: RECRUITING
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: Evolocumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of Adaptive Treatment Strategies for Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Antipsychotic|DRUG: Antidepressant|DRUG: Benzodiazepine|DRUG: Mood stabilizer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Laparoscopic Gastric Bypass Versus Laparoscopic Banded Gastric Bypass Randomized Prospective Clinical Trial
Status: ENROLLING_BY_INVITATION
Conditions: Morbid Obesity|Weight Loss|Postoperative Complications
Interventions: DEVICE: Banded (with polypropylene mesh) gastric bypass|PROCEDURE: Gastric bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Assessing the Safety and Ocular Hypotensive Efficacy of AR-12286 in Patients With Elevated Intraocular Pressure for 3 Months
Status: COMPLETED
Conditions: Ocular Hypertension|Open-angle Glaucoma
Interventions: DRUG: AR-12286 Ophthalmic Solution 0.7%|DRUG: AR-12286 Ophthalmic Solution 0.5%|DRUG: Timolol maleate ophthalmic solution 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Immune Reactivity of the Liquid and Lyophilized Formulations of Palivizumab (MEDI-493, Synagis)
Status: COMPLETED
Conditions: Chronic Lung Disease
Interventions: BIOLOGICAL: Lyophilized Palivizumab|BIOLOGICAL: Liquid Palivizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sodium Tanshinone IIA Sulfonate in Left Ventricular Remodeling Secondary to Acute Myocardial Infarction
Status: UNKNOWN
Conditions: Left Ventricular Remodeling|Acute Myocardial Infarction
Interventions: DRUG: sodium tanshinone IIA sulfonate|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Durvalumab and Tremelimumab for Adjuvant Therapy of Resected NSCLC
Status: WITHDRAWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Durvalumab|DRUG: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Pharmacokinetics of the MMP-12 Inhibitor FP-025 After Multiple Oral Ascending Doses in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: FP-025 (MMP-12 inhibitor)|DRUG: FP-025 (MMP-12 inhibitor)|DRUG: FP-025 (MMP-12 inhibitor)|DRUG: FP-025 (MMP-12 inhibitor)|DRUG: FP-025 (MMP-12 inhibitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of the Photoallergy Potential of Xenaderm Ointment
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Ointment Vehicle|DRUG: Xenaderm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Study of Low Dose Whole Brain Irradiation in the Treatment of Alzheimer's Disease
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: RADIATION: 5 daily fractions of 2 Gy|RADIATION: 10 daily fractions of 2 Gy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenomic Study for Providing Personalized Strategy to the Treatment of Non-small Cell Lung Cancer (NSCLC) IIIB/IV
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: IP|DRUG: GP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Platelet Rich Plasma in the Management of Acute Hamstring Muscle Strain Injury
Status: COMPLETED
Conditions: Acute Hamstring Muscle Strain Injury
Interventions: BIOLOGICAL: Platelet Poor Plasma (PPP)|BIOLOGICAL: Platelet Rich Plasma (PRP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Viral and Microbial Circulation Between Humans, Domesticated and Wild Animals Along an Ecotone, Democratic Republic of Congo
Status: COMPLETED
Conditions: Zoonotic Disease
Interventions: BIOLOGICAL: blood sampling|BIOLOGICAL: stool collection|OTHER: Participatory activity and contact investigation|OTHER: Anthropological and historical interviews
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate GBT021601-012 Single Dose and Multiple Dose in Participants With Sickle Cell Disease (SCD)
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: GBT021601
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Post-operative TAP Block Improve Quality of Recovery After C-sections in Patients on Methadone Maintenance?
Status: WITHDRAWN
Conditions: Uncontrolled Postoperative Pain
Interventions: DRUG: 0.375% ROPIVACAINE|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Maximal Androgen Depletion Followed by Randomization of Maximal Androgen Ablation With Molecular Targeted Therapies
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Abiraterone Acetate|DRUG: Prednisone|DRUG: Sunitinib|DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Right Ventricular Systolic Function Using Real-time Three-dimensional Echocardiography in Intensive Care Unit Patients
Status: COMPLETED
Conditions: Ventricular Dysfunction, Right|Lung Diseases|Intensive Care Units
Interventions: DIAGNOSTIC_TEST: Real-time three-dimensional echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Objective Perfusion Rate Assessment by Near-infrared Fluorescence in Ileal Pouch Formation and Ileal-pouch-anal Anastomosis
Status: UNKNOWN
Conditions: Ulcerative Colitis|Colorectal Cancer|Crohn Disease|Familial Adenomatous Polyposis|Ulcerative Colitis in Remission|Ulcerative Colitis Chronic|Crohn Colitis|Ileal Pouch
Interventions: DIAGNOSTIC_TEST: ICG-NIRF Imaging plus ingress and egress analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of MRG003 in the Treatment of EGFR-positive Unresectable, Locally Advanced or Metastatic Biliary Tract Cancer
Status: RECRUITING
Conditions: Advanced or Metastatic Biliary Tract Cancer
Interventions: DRUG: MRG003
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycemic Index in Subjects With Diabetes Mellitus Insulin Requesting
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Low glycemic index|OTHER: High glycemic index
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hepatic Safety of Eviplera® in HIV/Hepatitis C (HCV)-Coinfected Patients Without HCV Treatment in the "The HEPAVIR HEPATIC SAFETY Cohort."
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV) Hepatitis C Virus (HCV) Coinfected Subjects
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Three Methods on Endotracheal Aspiration in Preterm Infants
Status: NOT_YET_RECRUITING
Conditions: Preterm|Pain, Acute|Physiological Stress|Nursing Care|Comfort
Interventions: OTHER: Facilitated Tucking|OTHER: Swaddling|OTHER: Prone Position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of XY0206 Tablets in Patients With Relapsed / Refractory Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: XY0206
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vacuum Assisted Therapy in Emergent Contaminated Abdominal Surgeries
Status: COMPLETED
Conditions: Gastrointestinal Injury|Complicated Diverticulitis
Interventions: DEVICE: "Veraflo" device, Dakin's solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and PEGPH20 in Treating Patients With Metastatic Pancreatic Cancer
Status: WITHDRAWN
Conditions: Metastatic Pancreatic Adenocarcinoma|Stage IV Pancreatic Cancer AJCC v8
Interventions: BIOLOGICAL: Pegylated Recombinant Human Hyaluronidase PH20|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D-biofortified Eggs on Wintertime Serum 25-hydroxyvitamin D in Adults: Randomized Controlled Trial
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Control eggs|DIETARY_SUPPLEMENT: Vitamin D3 eggs|DIETARY_SUPPLEMENT: 25-Hydroxyvitamin D3 eggs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Ranolazine on Activity Level in Patients With Angina After FFR Based Deferred Intervention (REPTAR)
Status: UNKNOWN
Conditions: Angina
Interventions: DRUG: Ranolazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Calcitriol and Dexamethasone Before Radical Prostatectomy in Treating Patients With Localized Adenocarcinoma (Cancer) of the Prostate
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: calcitriol|DRUG: dexamethasone|OTHER: clinical observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Therapy for Patients With Multiple Sclerosis Failing Alternate Approved Therapy- A Randomized Study
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: PROCEDURE: Hematopoietic Stem Cell Therapy|DRUG: Standard treatment with a conventional drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: QUALITOP - Monitoring Multidimensional Aspects of QUAlity of Life After Cancer ImmunoTherapy, an Open Smart Digital Platform for Personalized Prevention and Patient Management
Status: RECRUITING
Conditions: Solid Tumor|Hematologic Cancer
Interventions: OTHER: QoL & irAEs determinants|OTHER: QoL & irAEs determinants
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating an Online Acceptance and Commitment Training Program for Individuals With Chronic Health Conditions
Status: ACTIVE_NOT_RECRUITING
Conditions: Stress, Psychological|Depression|Well-Being, Psychological
Interventions: BEHAVIORAL: ACT Guide for Chronic Health Conditions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Clipping Via Keyhole Versus Traditional Approaches and Coiling for Ruptured Aneurysms
Status: COMPLETED
Conditions: Randomized Controlled Trial|Intracranial Aneurysm|Microsurgery|Endovascular Procedures
Interventions: PROCEDURE: keyhole microneurosurgery|PROCEDURE: conventional microneurosurgery|PROCEDURE: endovascular coiling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty: a Randomized Trial
Status: COMPLETED
Conditions: Knee Chondral or Osteochondral Defect
Interventions: PROCEDURE: Autologous chondrocytes transplantation|PROCEDURE: Mosaicoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Use of Postpartum Sertraline to Prevent Postpartum Depression
Status: TERMINATED
Conditions: Depression, Postpartum
Interventions: DRUG: Sertraline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Platycodon Grandiflorus Extract(GCWB107) on Decrease of Body Fat
Status: UNKNOWN
Conditions: Body Fat
Interventions: DIETARY_SUPPLEMENT: Platycodon Grandiflorus Extract(GCWB107)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Evaluation of Lapsed Contact Lens Wearers Who Are Re-fit Into Senofilcon A Contact Lenses
Status: COMPLETED
Conditions: Lapsed Contact Lens Wear
Interventions: DEVICE: senofilcon A|DEVICE: senofilcon A for Astigmatism
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propranolol and Pembrolizumab for Tumor Re-sensitization and Treatment of Patients With Checkpoint Inhibitor Refractory Metastatic or Unresectable Triple Negative Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Triple-Negative Breast Carcinoma|Refractory Triple-Negative Breast Carcinoma|Unresectable Triple-Negative Breast Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|BIOLOGICAL: Pembrolizumab|DRUG: Propranolol|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oocyte Survival After Vitrification With Slush Nitrogen Compared With Liquid Nitrogen
Status: COMPLETED
Conditions: Infertility
Interventions: OTHER: Vitrification via slush nitrogen|OTHER: Vitrification via liquid nitrogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Infective Complications in TP Biopsy Without Antibiotic Prophylaxis
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: PROCEDURE: Transperineal Biopsy without antibiotics prophylaxis|PROCEDURE: Transperineal Biopsy with antibiotics prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiometabolic Devices Accuracy Study
Status: COMPLETED
Conditions: Diabetes Mellitus|Chronic Kidney Diseases|Hyperlipidemias
Interventions: DEVICE: Determine the accuracy of quantitative measurements of GLU, HbA1c,CHOL and CRE with POC devices compared to a laboratory reference method (Roche)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Improvement Of Physical And Physiological Parameters In Menopausal Or Post-Menopausal Celiac Women
Status: COMPLETED
Conditions: Celiac Disease|Diet, Gluten-Free|Exercise|Resistance Training|Quality of Life|Body Composition
Interventions: BEHAVIORAL: Gluten-free nutrition plan + exercise group|BEHAVIORAL: Gluten-free nutrition plan group|BEHAVIORAL: Active Comparator: Celiac controls group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of an e-Home Based Symptom Management and Mindfulness Training Programme on QoL in Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer Survivors|Symptom Management|Mindfulness Based Cognitive Therapy|Quality of Life|Oncology
Interventions: OTHER: Online mindfulness training|OTHER: Online symptom management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cyclophosphamide Systemic Sclerosis Associated Interstitial Lung Disease
Status: COMPLETED
Conditions: Systemic Sclerosis|Scleroderma|Interstitial Lung Disease|Lung Fibrosis
Interventions: DRUG: Cyclophosphamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Using Physical Therapy Resources for Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis|Physical Therapy Modalities
Interventions: OTHER: exercise|DEVICE: interferential current|DEVICE: short-wave diathermy|DEVICE: Low level laser therapy|DEVICE: Ultrasound therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab in Treating Patients With Recurrent or Persistent Endometrial Cancer
Status: COMPLETED
Conditions: Recurrent Endometrial Carcinoma
Interventions: BIOLOGICAL: bevacizumab|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotics for Girls With Recurring Urinary Tract Infections
Status: WITHDRAWN
Conditions: Recurrent Urinary Tract Infection
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri DSM 17938|DRUG: trimethoprim/sulfamethoxazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: EMR-C VS EMR-S in Colonic Lateral Spreading Tumors Treatment (LST)
Status: UNKNOWN
Conditions: Endoscopic Mucosal Resection
Interventions: DEVICE: cap for mucosectomy|DEVICE: standard snare for polypectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Traumatic Brain Injury Rehab Care With Comm Health Services: a Research Project Within the TBI Model System
Status: RECRUITING
Conditions: Traumatic Brain Injury
Interventions: OTHER: Standard of Care|OTHER: Experimental
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of a Laser for the Treatment of Acne Vulgaris
Status: RECRUITING
Conditions: Acne Vulgaris
Interventions: DEVICE: 1726nm Laser System|DEVICE: Sham Laser System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of NeoRetina Artificial Intelligence Algorithm for the Screening of Diabetic Retinopathy at the CHUM
Status: NOT_YET_RECRUITING
Conditions: Diabetic Retinopathy|Diabetic Macular Edema|Diabetic Maculopathy
Interventions: DIAGNOSTIC_TEST: Screening of DR and DME with artificial intelligence using NeoRetina|DIAGNOSTIC_TEST: Routine ophthalmological evaluation of DR and DME|DIAGNOSTIC_TEST: Manual grading of DR and DME by CHUM ophthalmologists based on retinal photographies acquired by Diagnos
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Two Different Distraction Methods for Reducing Procedural Pain in Children
Status: NOT_YET_RECRUITING
Conditions: Procedural Pain
Interventions: OTHER: Parent-Provide Distraction|OTHER: Windmill Toy Blowing|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: This Study Tests BI 685509 in Healthy Chinese and Japanese Men; the Study Tests How Different Doses of BI 685509 Are Taken up in the Body and How Well They Are Tolerated
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 685509|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Red Wine Polyphenols on Microvascular Dysfunction
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Red Wine Polyphenols 600mg/day|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Posterior Capsular Opacification and Glistenings in Hydrophobic and Hydrophilic Intraocular Lenses
Status: UNKNOWN
Conditions: Cataract|Intraocular Lens Opacification
Interventions: DEVICE: RayOne® Hydrophobic lens 800C|DEVICE: RayOne® Hydrophilic lens 600C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Physical Therapy Intervention on Motor Delay in Infants Admitted to a Neonatal Intensive Care Unit
Status: RECRUITING
Conditions: Motor Delay|Premature Birth|Intraventricular Hemorrhage|Hypoxic-Ischemic Encephalopathy|Bronchopulmonary Dysplasia
Interventions: OTHER: Physical Therapy intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Post-Traumatic Stress Disorder (PTSD) and Chronic Pain After Traumatic Orthopedic Injury
Status: COMPLETED
Conditions: Chronic Pain|Post-traumatic Stress Disorder
Interventions: BEHAVIORAL: Brief Prolonged Exposure Protocol|BEHAVIORAL: Chronic Pain Management Treatment|BEHAVIORAL: Self-Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety Evaluation of Aminophylline and Ambrisentan When Administered Orally Alone and in Combination to Healthy Volunteers
Status: COMPLETED
Conditions: High Altitude Pulmonary Hypertension
Interventions: DRUG: Aminophylline|DRUG: Ambrisentan|DRUG: Aminophylline plus ambrisentan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Follow-up Study of Safety of Enteric-coated Mycophenolate Sodium in Patients Who Successfully Completed Study CERL080A302
Status: COMPLETED
Conditions: Renal Transplant
Interventions: DRUG: Mycophenolate sodium (enteric coated)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Direct vs Indirect Methods for Cascade Screening
Status: RECRUITING
Conditions: Long QT Syndrome|Familial Hypercholesterolemia|Ethics|Genetic Testing
Interventions: BEHAVIORAL: Direct contact of family members for cascade screening of relevant variants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Phase 1 Study of the Safety and Pharmacokinetics of AGS-8M4 in Subjects With Advanced Ovarian Cancer
Status: COMPLETED
Conditions: Carcinoma|Ovarian Cancer|Ovarian Diseases|Ovarian Neoplasms
Interventions: BIOLOGICAL: AGS-8M4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contextual Therapies and Cognitive Behavioral Therapy as Transdiagnostic Group Interventions for Emotional Disorders
Status: COMPLETED
Conditions: Anxiety|Depression
Interventions: BEHAVIORAL: Behavioral activation therapy|BEHAVIORAL: Acceptance and Commitment Therapy|BEHAVIORAL: Cognitive-Behavioral Therapy|OTHER: Wait List Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immune Reconstitution as a Determinant of Adverse Effects to New Antiretroviral Therapy in Persons With Advanced HIV Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Truvada (tenofovir/emtricitabine)|DRUG: Kaletra (lopinavir/ritonavir)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: External Oblique Intercostal Block Versus Paravertebral Block for Postoperative Analgesia in Laparoscopic Cholecystectomy Patients
Status: NOT_YET_RECRUITING
Conditions: Anesthesia
Interventions: PROCEDURE: The external oblique intercostal block|PROCEDURE: Paravertebral block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does the Suture-spanning Augmentation of Single-row Repair in Massive Rotator Cuff Tear Reduce the Retear Rate?
Status: COMPLETED
Conditions: Rotator Cuff Tear
Interventions: PROCEDURE: Suture-bridge augmentation of single-row repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Efficacy and Safety of AK111 in Subjects With Moderate-to-Severe Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: BIOLOGICAL: AK111/Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Translational Study to Examine the Effects of Shared Care in Management of Gestational Diabetes
Status: COMPLETED
Conditions: Gestational Diabetes Mellitus
Interventions: BEHAVIORAL: Shared glycaemic control care within the local three-tier's antenatal care network
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Multicenter Study to Evaluate the Efficacy and Safety of Oral ACT-539313 in the Treatment of Adults With Moderate to Severe Binge Eating Disorder
Status: COMPLETED
Conditions: Binge-Eating Disorder
Interventions: DRUG: ACT-539313|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Yield of Laryngeal Ultrasound in the Diagnosis of Laryngomalacia
Status: UNKNOWN
Conditions: Stridor|Laryngomalacia
Interventions: OTHER: laryngeal ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Anti-obesity Pharmacotherapy and Inflammation
Status: RECRUITING
Conditions: Obesity
Interventions: DRUG: Semaglutide|DRUG: Phentermine-Topiramate combination|DRUG: Phentermine|DRUG: Tirzepatide|DRUG: Topiramate|DRUG: Diethylpropion|DRUG: Naltrexone/Bupropion|DRUG: Liraglutide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared With Carboplatin-Pemetrexed, in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Amivantamab|DRUG: Pemetrexed|DRUG: Carboplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Effects of an Angiotensin Converting Enzyme Inhibitor in Adults With Chronic Kidney Disease of Uncertain Aetiology
Status: UNKNOWN
Conditions: Renal Insufficiency, Chronic
Interventions: DRUG: Enalapril|DRUG: Calcium Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: REGENESIS (US): A Phase IIb Prospective, Randomized, Double-blind, Placebo Controlled Study of NTx™-265: Human Chorionic Gonadotropin (hCG) and Epoetin Alfa (EPO) in Acute Ischemic Stroke Patients
Status: WITHDRAWN
Conditions: Stroke
Interventions: DRUG: NTx™-265: rhCG, then rEPO|DRUG: Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intraurethral Lidocaine Gel on Pain Perception During Flexible Cystoscopy
Status: UNKNOWN
Conditions: Flexible Cystoscopy
Interventions: DEVICE: Lidocaine gel|OTHER: Counselling|OTHER: Monitor|DEVICE: Lubricating gel|OTHER: No counselling|OTHER: No monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Olmesartan and Nebivolol on Ambulatory Blood Pressure and Arterial Stiffness in Acute Stage of Ischemic Stroke
Status: COMPLETED
Conditions: Stroke, Ischemic
Interventions: DRUG: Olmesartan|DRUG: Nebivolol|OTHER: No antihypertensive treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Medication Coordinator on the Quality of Patients Medication Treatment
Status: ENROLLING_BY_INVITATION
Conditions: Medication Review|Polypharmacy|Potentially Inappropriate Medication|Quality of Life|Medication Therapy Management
Interventions: BEHAVIORAL: Medication Coordinator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Exercise as a Supportive Measure for Patients Undergoing Checkpoint-inhibitor Treatment
Status: COMPLETED
Conditions: PD-1 Antibodies|Exercise|Melanoma
Interventions: BEHAVIORAL: Resistance and Endurance Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: E10A for the Treatment of Squamous Cell Carcinoma of the Head and Neck
Status: UNKNOWN
Conditions: Head and Neck Neoplasms
Interventions: DRUG: Endostatins|DRUG: Paclitaxel injection|DRUG: Cisplatin injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Bupivacaine in Total Knee Arthroplasty
Status: WITHDRAWN
Conditions: Pain, Postoperative|Arthroplasty, Replacement, Knee|Osteoarthritis
Interventions: DRUG: Liposomal bupivacaine|DRUG: bupivacaine HCl, morphine, epinephrine, methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Oral Iron With IV Iron in Patients With Anemia of Chronic Renal Failure Not on Dialysis
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Iron Sucrose + Erythropoietin|DRUG: Ferrous Sulfate + Erythropoietin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pilot Dose Finding and Pharmacokinetic Study of Fondaparinux in Children With Thrombosis
Status: COMPLETED
Conditions: Thrombosis|Heparin-induced Thrombocytopenia
Interventions: DRUG: Fondaparinux
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proteinopathies Expression in Skin of Neurodegenerative Disorders
Status: RECRUITING
Conditions: Alzheimer Disease|Frontotemporal Dementia|Parkinson Disease|Atypical Parkinsonism|Amyotrophic Lateral Sclerosis|Normal Pressure Hydrocephalus
Interventions: DIAGNOSTIC_TEST: Immunohistochemistry and immunofluorescence
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of IV PAPAVERINE 80 mg Prior to Catheter Balloon Insertion on Bishop Score and Pain
Status: RECRUITING
Conditions: Induction of Labor|Pain, Acute|Labor Pain|Delivery Delayed
Interventions: DRUG: IV Papaverine 80 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electronic-Nutrition-Optimizer for Personalized Prevention
Status: COMPLETED
Conditions: Diabetes|Hypertension|Frailty|Dementia|Cardiovascular Diseases
Interventions: DEVICE: eNutrition Optimizer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effectiveness of Narrow-band Ultraviolet B Combined With Topical Tacrolimus 0.03% in Treatment of Patients With Vitiligo
Status: UNKNOWN
Conditions: Vitiligo
Interventions: RADIATION: NB-UVB|COMBINATION_PRODUCT: NB-UVB & Tacrolimus 0.03%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Initiation of Androgen Deprivation Therapy for Prostate Cancer Using Degarelix Followed by Leuprolide
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Degarelix acetate, Leuprolide acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT