pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Enhancing One's Sense of Self Using Self-Affirmation
Status: COMPLETED
Conditions: Mental Health Wellness 1|Anxiety|Self Esteem
Interventions: BEHAVIORAL: Self-affirmation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cortical Neuroplasticity by Muscle Pain of Pain-induced Plasticity
Status: COMPLETED
Conditions: Nerve Growth Factor|Exercise|Motor Activity|Abnormality of SSEPs|Hyperalgesia
Interventions: DRUG: Sterile solutions of recombinant human nerve growth factor (NGF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PEEP Levels on Intraabdominal Pressure and Hemodynamics in Critically Ill Patients
Status: COMPLETED
Conditions: Intraabdominal Hypertension|Critically Ill|Hemodynamic Instability
Interventions: DIAGNOSTIC_TEST: Intraabdominal Pressure Measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Gemcitabine, Paclitaxel and Oxaliplatin (GemPOx)
Status: COMPLETED
Conditions: CNS Germ Cell Tumor
Interventions: DRUG: Gemcitabine, Paclitaxel and Oxaliplatin (GemPOx).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Tobacco Control and Smoking Cessation in Workplaces [Phase I]
Status: COMPLETED
Conditions: Smoking
Interventions: BEHAVIORAL: Workshop|BEHAVIORAL: Face-to-face counseling|BEHAVIORAL: Phone counseling|BEHAVIORAL: Health talk|BEHAVIORAL: Booklet|BEHAVIORAL: SMS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Sterile Versus Clean Gloves Intrapartum and Postpartum Infections at Term
Status: TERMINATED
Conditions: Chorioamnionitis|Intrauterine Infection|Postpartum Endometritis|Puerperal Infection
Interventions: PROCEDURE: Cervical examination to assess labor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Recombinant Human FGF21-Fc Fusion Protein for Injection (TQA2225/AP025) in Adult Subjects With Non-alcoholic Steatohepatitis (NASH)
Status: RECRUITING
Conditions: Non-alcoholic Steatohepatitis
Interventions: DRUG: TQA2225/AP025 or TQA2225/AP025 Placebo 25mg|DRUG: TQA2225/AP025 or TQA2225/AP025 Placebo 50mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sintilimab and Bevacizumab Biosimilar Combined With PLD in mTNBC
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: sintilimab|DRUG: bevacizumab biosimilar|DRUG: pegylated liposomal doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Safety of NovoPen® 3 and/or FlexPen® Devices in Routine Clinical Practice
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2|Delivery Systems
Interventions: DEVICE: FlexPen®|DEVICE: NovoPen® 3
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Ten-Weeks Power Training on Neuromuscular Performance, Heart Rate Variability, Sleep Quality and Mobility in Persons With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: OTHER: Resistance training|OTHER: Testing sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Chronic Urticarial Unresponsive to H1-antihistamines With an Anti-IL5Ralpha Monoclonal Antibody
Status: COMPLETED
Conditions: Chronic Idiopathic Urticaria
Interventions: BIOLOGICAL: benralizumab|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Use of EBPT in Critically Ill Patients With AKI and/or Multiorgan Failure
Status: RECRUITING
Conditions: Critical Illness|Acute Kidney Injury|Sepsis|Systemic Inflammatory Response Syndrome
Interventions: DEVICE: Commercial membrane for Extracorporeal Blood Purification Therapy (EBPT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Closed-loop in Adults With T2D Not Requiring Dialysis
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DEVICE: CamAPS HX Closed-loop|OTHER: Multiple Daily Insulin Injections (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aflibercept (Eylea) in roUtine Clinical Practice in patientS With Wet Age-related Macular Degeneration in Italy
Status: COMPLETED
Conditions: Wet Macular Degeneration
Interventions: DRUG: Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of NKTR-358 (LY3471851) in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3471851|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Retrospective Study of Newly-diagnosed PCNSL Treated With a Methotrexate (MTX) and Orelabrutinib-based Regimen
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Central Nervous System Lymphoma
Interventions: DRUG: Orelabrutinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Real-World Effectiveness of Afatinib (Gilotrif) Following Immunotherapy in the Treatment of Metastatic, Squamous Cell Carcinoma of the Lung: A Multi-Site Retrospective Chart Review Study in the U.S.
Status: COMPLETED
Conditions: Non-squamous, Non-Small Cell Lung Cancer
Interventions: DRUG: Afatinib|DRUG: other systemic therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Respiratory Physiotherapy Performed by Simeox In Patients With Primary Ciliary Dyskinesia
Status: COMPLETED
Conditions: Primary Ciliary Dyskinesia
Interventions: DEVICE: Simeox|DEVICE: PARI O PEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessing the Efficacy of an Acceptance-Based Digital Intervention for Veterans With Chronic Pain
Status: RECRUITING
Conditions: Chronic Pain
Interventions: BEHAVIORAL: Veteran ACT for Chronic Pain (VACT-CP)|BEHAVIORAL: Online Pain School
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Percutaneous Coronary Intervention Optimization With Fractional Flow Reserve Versus Intravascular Ultrasound in the Treatment of Long Coronary Artery Lesions
Status: COMPLETED
Conditions: Coronary Artery Disease|Myocardial Ischemia|Myocardial Infarction
Interventions: PROCEDURE: IVUS guided PCI optimization|PROCEDURE: FFR guided PCI optimization|DIAGNOSTIC_TEST: FFR measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Immunogenicity of Inactivated Influenza Virus Vaccine Among Healthy Children 6-12 Weeks of Age
Status: COMPLETED
Conditions: Inactivated Influenza Vaccine
Interventions: BIOLOGICAL: 2005-2006 trivalent inactivated influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MTHFR Mutation and Concentration of B12,Folic Acid,Homocysteine and HS CRP in the Blood of Pregnant Women With GDM.
Status: COMPLETED
Conditions: Gestational Diabetes
Interventions: OTHER: Blood sampling and determination of MTHFR mutation,vitamin B12, folic acid, homocystein and HS CRP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CSL324 in COVID-19
Status: WITHDRAWN
Conditions: Coronavirus Disease 2019 (COVID-19)
Interventions: BIOLOGICAL: CSL324|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Oral Step-down Antibiotic Therapy for Uncomplicated Gram-negative Bacteraemia
Status: RECRUITING
Conditions: Gram-negative Bacteraemia
Interventions: DRUG: Oral fluoroquinolones (most commonly, ciprofloxacin) or oral trimethoprim-sulfamethoxazole|DRUG: Standard of care intravenous antibiotics (e.g. ceftriaxone, cefazolin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: QS21|BIOLOGICAL: IFA (incomplete Freund's adjuvant)|BIOLOGICAL: p946|BIOLOGICAL: p946/tet-p|BIOLOGICAL: Tet-p
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety/Efficacy Study of Bovine Intestinal Alkaline Phosphatase in Patients With Moderate to Severe Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: bovine intestinal alkaline phosphatase (BIAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Verinurad in Heart Failure With Preserved Ejection Fraction
Status: COMPLETED
Conditions: Heart Failure With Preserved Ejection Fraction (HFpEF)
Interventions: DRUG: Verinurad|DRUG: Allopurinol|DRUG: Placebo for verinurad|DRUG: Placebo for allopurinol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TACE Combined With Penpulimab and Anlotinib for Advanced HCC
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: TACE+penpulimab+anlotinib vs. penpulimab+anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of TAK-438 Compared to AG-1749 (Lansoprazole) in the Treatment of Duodenal Ulcer
Status: COMPLETED
Conditions: Duodenal Ulcer
Interventions: DRUG: TAK-438|DRUG: Placebo|DRUG: Lansoprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PleuraSeal Pivotal Study (US)
Status: TERMINATED
Conditions: Open Thoracotomy
Interventions: DEVICE: PleuraSeal Sealant System|PROCEDURE: Standard Tissue Closure Techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Tobacco Related Health Disparities
Status: COMPLETED
Conditions: Smoking Cessation|Smoking
Interventions: BEHAVIORAL: Standard Treatment (ST)|BEHAVIORAL: Telephone Counseling|BEHAVIORAL: Quitline|BEHAVIORAL: Nicotine Replacement Therapy (NRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intramuscular Injections of Botulinum Toxin in Lateral Pterygoid Muscle in the Treatment of Temporomandibular Dysfunctions: Studying the Interest of MRI Guidance and Ultrasound Guidance
Status: UNKNOWN
Conditions: Mandibular Dysfunction
Interventions: DEVICE: MRI guidance|DEVICE: Ultrasound guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Senescent Immunity in Elders and Vaccine Responses (SILVER)
Status: COMPLETED
Conditions: Flu Vaccine
Interventions: BIOLOGICAL: Fluzone-High Dose Quadrivalent|BIOLOGICAL: Fluad|BIOLOGICAL: Flublock
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Venetoclax and Azacitidine for Non-Elderly Adult Patients With Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Neoadjuvant Immunotherapy Increasing CD8+ Cell Infiltration in Advance Gastric Adenocarcinoma
Status: NOT_YET_RECRUITING
Conditions: Advanced Gastric Carcinoma|CD8+ Tumor Infiltrating Lymphocytes|Neoadjuvant Immunotherapy
Interventions: COMBINATION_PRODUCT: radical surgery after neoadjuvant immunotherapy|COMBINATION_PRODUCT: radical surgery after neoadjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Vascutek AnacondaTM Stent Graft System Phase II IDE Study
Status: COMPLETED
Conditions: Infrarenal Abdominal Aortic Aneurysm
Interventions: DEVICE: Anaconda Stent Graft System|DEVICE: Anaconda ONE-LOK Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stem Cells in Spinal Cord Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Cord Injuries|Acute Spinal Cord Injury|Paraplegia, Spinal|Paraplegia; Traumatic
Interventions: BIOLOGICAL: Neuro-Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Glucose Control, β Cell Function in Response to Short-term Insulin Pump Therapy in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin LISPRO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Safety, Tolerability and Antitumor Activity of Genetically Engineered T Cells in Combination With Anti-Cancer Agents in Relapsed and Refractory Synovial Sarcoma Expressing New York Esophageal Antigen-1 (NY-ESO-1) and/or LAGE-1a
Status: WITHDRAWN
Conditions: Neoplasms
Interventions: DRUG: GSK3377794|DRUG: Pembrolizumab|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Amniotomy After Vaginal Prostaglandin E2 for Induction of Labor at Term: a Randomized Clinical Trial
Status: COMPLETED
Conditions: Early Amniotomy, Unfavorable Cervix
Interventions: DRUG: PGE2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Disitamab Vedotin Combined With Tislelizumab for Her2 Overexpressing High-Risk Non-Muscle-Invasive Urothelial Bladder Carcinoma Which is Not Completely Resectable
Status: RECRUITING
Conditions: Her2 Overexpressing High-Risk Non-Muscle Invasive Bladder Urothelial Carcinoma
Interventions: DRUG: Disitamab Vedotin Tislelizumab|DRUG: Disitamab Vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug-drug Interaction Trial of Rifampicin Pharmacokinetics Effect on Fluzoparib
Status: COMPLETED
Conditions: Healthy Male Subjects
Interventions: DRUG: Fluzoparib|DRUG: Rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prolonged Exposure and Oxytocin
Status: COMPLETED
Conditions: PTSD
Interventions: DRUG: Oxytocin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Postural Control in Children With Idiopathic Toe Walking
Status: COMPLETED
Conditions: Idiopathic Toe Walking|Gait Disorders in Children|Postural Control|Postural Stability|Balance
Interventions: OTHER: Biodex Balance System|OTHER: Balance Error Scoring System (BESS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Coronary Sinus Pressure and Microvascular Disease
Status: COMPLETED
Conditions: Microvascular Coronary Artery Disease
Interventions: DEVICE: Swan-Ganz catheter placed in the coronary sinus - deflated|DEVICE: Swan-Ganz catheter placed in the coronary sinus - inflated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Obeticholic Acid in Pediatric Subjects With Biliary Atresia
Status: TERMINATED
Conditions: Biliary Atresia
Interventions: DRUG: OCA 0.1mg|DRUG: OCA 1.5mg|DRUG: OCA 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Utility of Functionally Relevant Signature Genes in Assessing the Clinical Outcomes of Dupilumab Treatment
Status: COMPLETED
Conditions: Atopic Dermatitis|Eczema
Interventions: BIOLOGICAL: Dupilumab Prefilled Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Ipratropium / Levosalbutamol Fixed Dose Combination and Ipratropium and Levosalbutamol Free Dose Combination in pMDI Form in Stable Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: COPD
Interventions: COMBINATION_PRODUCT: Ipratropium / Levosalbutamol Fixed Dose Combination|DRUG: Ipratropium + Levosalbutamol Free Dose Combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Supplementation of Gangliosides to Treat a Rare Metabolic Disorder
Status: UNKNOWN
Conditions: GM3 Synthase Deficiency
Interventions: DIETARY_SUPPLEMENT: Supplementation of dairy-derived concentrated gangliosides.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Anesthesia and Intra-arterial Chemotherapy for Retinoblastoma
Status: WITHDRAWN
Conditions: Hemodynamic Instability
Interventions: DRUG: Tetracaine 0.5%|DRUG: Lidocaine hydrochloride ophthalmic gel 3.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Interactive Physical and Cognitive Exercise System (v3) for Mild Cognitive Impairment (MCI)
Status: UNKNOWN
Conditions: MCI|Mild Cognitive Impairment|Alzheimer Disease|Dementia
Interventions: DEVICE: iPACES (interactive Physical and Cognitive Exercise System)|DEVICE: PACE (Physical and Cognitive Exercise)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chimeric Antigen Receptor T Cell Therapy Redirected to CD4 (CD4CAR)as a Second Line Treatment for Chronic Myelomonocytic Leukemia, CMML.
Status: RECRUITING
Conditions: Chronic Myelomonocytic Leukemia
Interventions: BIOLOGICAL: CD4CAR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short-Term Effectiveness of Ultrasound-Guided Corticosteroid Hydrodissection
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: OTHER: Corticosteroid Hydrodissection|OTHER: Corticosteroid Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Multicenter Atherectomy Study Showing Luminal Gain in Subjects With Peripheral Vascular Blockages
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: Atherectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, Reactogenicity & Immunogenicity of the Rotarix Vaccine in Japanese Infants
Status: COMPLETED
Conditions: Infections, Rotavirus|Rotavirus Vaccines
Interventions: BIOLOGICAL: Rotarix|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Surgical Scars Following Breast Augmentation, Abdominoplasty or Face Lift
Status: COMPLETED
Conditions: Surgical Scar|Breast Augmentation|Abdominoplasty|Face Lift
Interventions: DEVICE: Fractional Radiofrequency (FRF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Herbal Formula Corresponding to Syndrome in Treating Post Percutaneous Coronary Intervention (PCI) Patients With Coronary Heart Disease (CHD)
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DRUG: Xuefu Zhuyu Capsules Plus Placebo of Sheng Mai Capsules,|DRUG: Sheng Mai Capsules Plus Placebo of Xuefu Zhuyu Capsules|DRUG: Placebo of Xuefu Zhuyu Capsules Plus Placebo of Sheng Mai Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Dendritic Cells Versus Montanide as Adjuvants in a Melanoma Vaccine
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: KLH; Peptides; Dendritic Cells|DRUG: KLH, peptides plus Montanide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monopolar Current Cutting Knife vs Bipolar RFA Knife
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastrointestinal Neoplasms
Interventions: PROCEDURE: Endoscopic Submucosal Dissection|PROCEDURE: Endoscopic Mucosal Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PuraPly® AM Plus the Standard of Care to Standard of Care Alone for the Management of Stage II-IV Pressure Ulcers.
Status: TERMINATED
Conditions: Chronic Pressure Ulcers
Interventions: DEVICE: PuraPly® Antimicrobial Wound Matrix|OTHER: SOC for Pressure Ulcers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Evaluate PF-04965842 in Patients With Moderate to Severe Psoriasis
Status: TERMINATED
Conditions: Plaque Psoriasis
Interventions: DRUG: PF-04965842|DRUG: PF-04965842|DRUG: PF-04965842|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sacituzumab Govitecan and Bevacizumab for NSCLC Brain Metastases
Status: NOT_YET_RECRUITING
Conditions: NSCLC Stage IV|Brain Metastases, Adult
Interventions: DRUG: Sacituzumab Govitecan-Hziy 180 MG plus bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Suppression of Endogenous Glucose Production by Injectable HDV-Insulin Lispro: A Dose Response Study in Human Subjects With Type 1 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Type 1 Diabetes
Interventions: DRUG: HDV-Insulin Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Short-term Efficacy of Gastrodia and Uncaria Drink in Treating Hypertension
Status: UNKNOWN
Conditions: Masked Hypertension
Interventions: DRUG: Gastrodia and Uncaria Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Exercise Capacity in Non-cystic Fibrosis Bronchiectasis After a Pulmonary Rehabilitation Home-based Program
Status: COMPLETED
Conditions: Non-cystic Fibrosis Bronchiectasis|Pulmonary Rehabilitation
Interventions: OTHER: Pulmonary rehabilitation home-based program intervention group (PRHP)(IG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effects of Music and Television on Intraoperative Hypertensive Events in Cataract Surgery
Status: COMPLETED
Conditions: Anxiety|Intraoperative Hypertension|Cataract
Interventions: OTHER: Music Intervention|OTHER: Television Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Transcranial Weak Current Stimulation Treatments for Working Memory Dysfunction in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizo Affective Disorder
Interventions: DEVICE: transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Quinidine Alone and in Combination With Dabigatran Etexilate
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: dabigatran etexilate|DRUG: quinidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Management of DIEP Flaps
Status: UNKNOWN
Conditions: Mammaplasty|Microsurgery|Free Tissue Flaps
Interventions: DRUG: Crystalloid Solutions|DRUG: Catecholamines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pulsatile Gonadotropin-releasing Hormone for Infertility in Non-obese Patients With Polycystic Ovary Syndrome
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome|Infertility|Ovulation Disorder
Interventions: DRUG: Gonadorelin|DRUG: Clomiphene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Adebrelimab Plus Etoposide and Cisplatin in Neuroendocrine Bladder Carcinoma
Status: RECRUITING
Conditions: Neuroendocrine Carcinoma of the Bladder|Bladder Cancer
Interventions: DRUG: Adebrelimab|DRUG: Etoposide|DRUG: Cisplatin|PROCEDURE: Radical Cystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study Comparing Taletrectinib With Standard Therapy in ROS1 Positive Locally Advanced or Metastatic Non-small Cell Lung Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Taletrectinib|DRUG: Crizotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Dry Needling Session of the Obliquus Capitis Inferior for the Altered Sensorimotor Function in People With Neck Pain
Status: COMPLETED
Conditions: Whiplash Syndrome|Neck Pain
Interventions: OTHER: dry needling|OTHER: Sham needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating the Effect of NN5401 in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec/insulin aspart|DRUG: insulin degludec/insulin aspart|DRUG: insulin degludec/insulin aspart|DRUG: biphasic insulin aspart 30|DRUG: biphasic insulin aspart 30|DRUG: biphasic insulin aspart 30
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Stereotactic Body Radiation Therapy for Resectable Adenocarcinoma of the Pancreatic Head and/or Body
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Daratumumab, Clarithromycin, Pomalidomide And Dexamethasone (D-ClaPd) In Multiple Myeloma Patients Previously Exposed to Daratumumab
Status: RECRUITING
Conditions: Multiple Myeloma|Refractory Multiple Myeloma|Relapse Multiple Myeloma
Interventions: DRUG: Daratumumab SC|DRUG: Clarithromycin|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Using 3D Motion Tracking Toothbrush in Dental Plaque Control
Status: COMPLETED
Conditions: Toothbrushing
Interventions: DEVICE: The smart toothbrush and smart mirror (STM) system (XiuSolution, Gyeonggi-do, Korea)|DEVICE: Conventional toothbrush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of the Efficacy and Safety of Two Insulin Intensification Strategies
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin Lispro Low Mixture (LM)|DRUG: Insulin Glargine|DRUG: Prandial Insulin Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study on the Therapeutic Effect and Mechanism of Transcutaneous Acupoint Electrical Stimulation in Female
Status: RECRUITING
Conditions: Dysmenorrhea
Interventions: DEVICE: Transcutaneous electrical acupoint stimulation|DRUG: non steroidal anti inflammatory drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Allstate and Nasal Allergen Challenge
Status: WITHDRAWN
Conditions: Allergic Rhinitis
Interventions: DEVICE: Allstate Nasal Spray|DEVICE: Placebo Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AG-013736 In Combination With Docetaxel Versus Docetaxel Alone For Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Placebo|DRUG: Docetaxel|DRUG: AG-013736 (axitinib)|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Essential Amino Acids Supplementation and Muscle Protein Synthesis
Status: COMPLETED
Conditions: Muscle Loss|Muscle Anabolism
Interventions: DIETARY_SUPPLEMENT: Essential Amino Acids|OTHER: Endurance exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: FM101 Efficacy Study in Adults With Nonalcoholic Fatty Liver Disease or Nonalcoholic Steatohepatitis
Status: UNKNOWN
Conditions: Nonalcoholic Fatty Liver Disease|Nonalcoholic Steatohepatitis
Interventions: DRUG: Placebo|DRUG: FM101 150 mg BID|DRUG: FM101 300 mg BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pupillary Diameter Under Different Concentrations of Propofol
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Propofol|DEVICE: Pupillary diameter measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of the Ultrasound-guided Paravertebral Nerve Block With Liposomal Bupivacaine Versus Ropivacaine for Post-Surgical Pain After Video-Assisted Thoracoscopic Surgery
Status: NOT_YET_RECRUITING
Conditions: Analgesia
Interventions: DRUG: Liposomal bupivacaine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study for Adaptive Deep Brain Stimulation (aDBS)Controlled by Intracerebral Activity in Parkinson's Disease
Status: UNKNOWN
Conditions: Advanced Parkinson's Disease
Interventions: DEVICE: aDBS|DEVICE: DBS
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Evaluation of [18F]MK-6240 PET as an Imaging Marker for Tau Protein
Status: COMPLETED
Conditions: Alzheimer Disease|Healthy Volunteers
Interventions: DRUG: [18F] MNI-946|DRUG: [18F]Florbetapir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Value of Genetic Counseling and Testing for Patients Who Would Like to Know More About Their Personal Risk of AMD
Status: COMPLETED
Conditions: Age-Related Macular Degeneration|Choroidal Neovascularization|Genetic Counseling
Interventions: BEHAVIORAL: Early disclosure|BEHAVIORAL: Late disclosure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Attention & Memory Impairments in Menopausal Women
Status: COMPLETED
Conditions: Symptomatic Menopause|Cognitive Impairments
Interventions: DRUG: Lisdexamfetamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drainage of Traumatic Hemothorax and Pneumothorax: Small Bore Versus Large Bore Chest Drain
Status: COMPLETED
Conditions: Traumatic Hemothorax and Pneumothorax
Interventions: DEVICE: Intercostal drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-Human Safety, PK, and Food Effect Study of Single Ascending Doses of G1T38 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: G1T38 (CDK 4/6 Inhibitor)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Direct Thrombin Inhibitors Versus LMWH in Staphylococcus Aureus Bacteraemia
Status: COMPLETED
Conditions: Staphylococcus Aureus Bacteraemia
Interventions: DRUG: direct thrombin inhibition|DRUG: enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effectiveness of Fluoroscopy-guided MLD for Treatment of BCRL
Status: COMPLETED
Conditions: Breast Neoplasm|Lymphedema
Interventions: OTHER: Information|OTHER: Skin care|OTHER: Compression therapy|OTHER: Fluoroscopy-guided MLD|OTHER: Traditional MLD|OTHER: Placebo MLD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Amrubicin as Second-Line Therapy in Patients With Advanced/Metastatic Refractory Urothelial Carcinoma
Status: TERMINATED
Conditions: Bladder Cancer
Interventions: DRUG: Amrubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Antiviral Activity of Entecavir in Participants With Chronic Hepatitis B Following Monotherapy in Other Entecavir Trials
Status: COMPLETED
Conditions: Hepatitis B Virus|HBV
Interventions: DRUG: Entecavir|DRUG: Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AvidinOX + [177Lu]DOTA-biotin (or 177Lu-ST2210) Complex in Patients With Liver Metastases From Colorectal Cancer
Status: TERMINATED
Conditions: Liver Metastases
Interventions: COMBINATION_PRODUCT: AvidinOX/ST2210
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Efficacy, Immunological Response of Intratumoral/Intralesional Oncolytic Virus (OBP-301) in Metastatic Melanoma
Status: UNKNOWN
Conditions: Melanoma Stage III|Melanoma Stage Iv
Interventions: DRUG: OBP-301
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Neuropsychological Investigations in Batten Disease
Status: RECRUITING
Conditions: Neuronal Ceroid Lipofuscinosis|Neuronal Ceroid Lipofuscinosis CLN1|Neuronal Ceroid Lipofuscinosis CLN2|Neuronal Ceroid Lipofuscinosis CLN3|Neuronal Ceroid Lipofuscinosis CLN5|Neuronal Ceroid Lipofuscinosis CLN6|Neuronal Ceroid Lipofuscinosis CLN7|Neuronal Ceroid Lipofuscinosis CLN8|Neuronal Ceroid Lipofuscinosis CLN10|Batten Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of Aplindore on the Treatment of Signs and Symptoms of Parkinson's Disease
Status: COMPLETED
Conditions: Early Stage Parkinson's Disease
Interventions: DRUG: Aplindore|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Fasting in Patients With a History of PCI
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: BEHAVIORAL: fasting|BEHAVIORAL: not fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Use of a Probiotic in SCORAD Reduction in Young Patients With Atopic Dermatitis
Status: UNKNOWN
Conditions: Atopic Dermatitis
Interventions: DIETARY_SUPPLEMENT: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Development and Testing of a Clinic-Based Intervention to Increase Dual Protection Against Unintended Pregnancy and Sexually Transmitted Diseases (STDs) Among High Risk Female Teens
Status: COMPLETED
Conditions: Pregnancy|Sexually Transmitted Diseases
Interventions: BEHAVIORAL: Interactive multimedia platform|BEHAVIORAL: Intervention arm counseling|BEHAVIORAL: Standard of care counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Stroke and Tocotrienol: Unique Role in Neuroprotection
Status: UNKNOWN
Conditions: Ischemic Stroke
Interventions: DIETARY_SUPPLEMENT: Tocotrienol|DIETARY_SUPPLEMENT: Placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Local Anaesthetic for Transvaginal Egg Collection in IVF
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: lignocaine|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 3 Crossover Trial of Two Formulations of Setmelanotide in Patients With Specific Gene Defects in the MC4R Pathway
Status: COMPLETED
Conditions: Bardet-Biedl Syndrome|POMC Deficiency
Interventions: DRUG: Setmelanotide 20mg weekly|DRUG: Placebo daily|DRUG: Setmelanotide 30mg weekly|DRUG: Setmelanotide 2mg daily|DRUG: Setmelanotide 3mg daily|DRUG: Placebo weekly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of BI 1744 CL in Patients With Chronic Obstructive Pulmonary Disease I
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Olodaterol (BI 1744)|DRUG: Olodaterol (BI 1744)|DRUG: Formoterol|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of AVP-923 in the Treatment of IEED (Involuntary Emotional Expression Disorder) Also Known as Pseudobulbar Affect (Episodes of Uncontrolled Crying and/or Laughter)
Status: COMPLETED
Conditions: Alzheimer's Disease|Stroke|Parkinson's Disease|Traumatic Brain Injury
Interventions: DRUG: AVP-923
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of High Dose IVIG in Hospitalized Participants With Coronavirus Disease (COVID-19)
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Intravenous Immune Globulin|DRUG: Standard Medical Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Chemoradiotherapy With Gemcitabine for Resectable Pancreatic Carcinoma
Status: TERMINATED
Conditions: Resectable Pancreatic Carcinoma
Interventions: RADIATION: chemoradiotherapy with Gemcitabine|RADIATION: Radiation: chemoradiotherapy with Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnesium vs Placebo for Tonsillectomy
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Magnesium|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FMT for Steroid Resistant Gut Acute GVHD
Status: UNKNOWN
Conditions: Stem Cell Transplant Complications|Acute Graft-Versus-Host Disease|Fecal Microbiota Transplantation
Interventions: BIOLOGICAL: Fecal Microbiota Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Therapeutic Outcomes in the Tongue Carcinoma Patient: Assessment of Adaptation Using Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging
Status: COMPLETED
Conditions: Tongue Carcinoma
Interventions: PROCEDURE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: IXAZOMIB Plus Lenalidomide and Dexamethasone Versus Placebo Plus Lenalidomide and Dexamethasone in Adult Patients With Newly Diagnosed Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Ixazomib|DRUG: Placebo|DRUG: Dexamethasone|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis
Status: NOT_YET_RECRUITING
Conditions: Bronchiolitis|Virus|Virus Disease
Interventions: RADIATION: Intervention Group photobiomodulation|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Probiotics Administration in the Immunotherapy of Urothelial Bladder Carcinoma
Status: RECRUITING
Conditions: Bladder Urothelial Carcinoma
Interventions: DRUG: Live Combined (Bifidobacterium,Lactobacillus and Enterococcus Capsules)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tucatinib, Trastuzumab, Ramucirumab, and Paclitaxel Versus Paclitaxel and Ramucirumab in Previously Treated HER2+ Gastroesophageal Cancer
Status: COMPLETED
Conditions: Gastric Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma|Esophageal Adenocarcinoma
Interventions: DRUG: tucatinib|DRUG: trastuzumab|DRUG: ramucirumab|DRUG: paclitaxel|OTHER: tucatinib placebo|OTHER: trastuzumab placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fondaparinux in Patients With Acute Heparin-Induced Thrombocytopenia (HIT)
Status: WITHDRAWN
Conditions: Heparin-Induced Thrombocytopenia
Interventions: DRUG: fondaparinux|DRUG: argatroban or lepirudin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of α-blocker or 5-ARI Withdrawal to Continued Combination Therapy on the Maintenance of LUTS in Men With BPH
Status: UNKNOWN
Conditions: Prostatic Hyperplasia|Prostate Hyperplasia|Prostatic Hypertrophy
Interventions: DRUG: alpha-blocker or 5-ARI withdrawal|DRUG: Maintenance of alpha-blocker and 5-ARI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Unmasked Evaluation of the iStent in Patients With Primary Open-Angle Glaucoma
Status: COMPLETED
Conditions: Glaucoma|Eye Diseases|Glaucoma, Open-Angle
Interventions: DEVICE: iStent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT