pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: IL-6 Regulation of Substrate Metabolism and Influence of Obesity
Status: COMPLETED
Conditions: Obesity|Healthy
Interventions: DRUG: Tocilizumab infusion|DRUG: Saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Puerarin Versus Atorvastatin in Treating Metabolism Syndrome in Patients With Chronic Rheumatic Diseases
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: puerarin tablet 50 mg|DRUG: Atorvastatin tablet 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin and Topotecan in Treating Patients With Previously Treated Ovarian Epithelial, Primary Peritoneal, or Fallopian Tube Cancer
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Peritoneal Cavity Cancer
Interventions: DRUG: oxaliplatin|DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Botulinum Toxin A for the Treatment of Refractory Overactive Bladder.
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: Botulinum Toxin A (Botox )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Genicular Artery Embolization (GAE) for Osteoarthritic Knee Pain
Status: RECRUITING
Conditions: Knee Osteoarthritis|Knee Pain Chronic|Knee Pain Swelling|Knee Arthritis|Arterial Occlusion
Interventions: DEVICE: Genicular artery embolization (GAE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic-robotic Hysterectomy for Uterine Transplantation in Live-donor Patient.
Status: UNKNOWN
Conditions: Uterine Anomaly
Interventions: PROCEDURE: Transplantation of the uterus from live donor.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dimethyl Fumarate (DMF, Tecfidera®) Persistence in RR-MS Patients Included in the French Patient Support Program OroSEP
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Dimethyl Fumarate|OTHER: PSP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Crystalloid and Colloid I.V Fluid Therapy in Prevention of Paracentesis Induced Circulatory Dysfunction (PICD) and Renal Dysfunction in Patients With Decompensated Liver Cirrhosis in Egypt: a Randomized Piolet Study
Status: UNKNOWN
Conditions: Ascites
Interventions: OTHER: Paracentesis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metformin in Amnestic Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Axillary Hyperhidrosis With Long-pulsed Nd:YAG Laser or IPL
Status: UNKNOWN
Conditions: Hyperhidrosis Primary Focal Axilla
Interventions: DEVICE: Long-pulsed Nd Yag laser treatment|DEVICE: IPL treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OnabotulinumtoxinA Bladder Injection Study
Status: TERMINATED
Conditions: Overactive Bladder|Overactive Bladder Syndrome|Urinary Urgency|Urinary Incontinence|Urinary Frequency/Urgency|Urinary Bladder, Overactive
Interventions: DRUG: OnabotulinumtoxinA 100Unit Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for the Treatment of Fuchs' Corneal Endothelial Dystrophy (FCED)
Status: COMPLETED
Conditions: Fuchs' Corneal Endothelial Dystrophy (FCED)
Interventions: DRUG: Part A Elamipretide 1.0% Ophthalmic Solution|DRUG: Part B Elamipretide 3.0% Ophthalmic Solution|DRUG: Part A Placebo|DRUG: Part B Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Suptavumab (REGN2222) for the Prevention of Medically Attended RSV (Respiratory Syncytial Virus) Infection in Preterm Infants
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: DRUG: Suptavumab 30 mg/kg|DRUG: Placebo Matched to Suptavumab|DRUG: Suptavumab 30 mg/kg- 1 Dose|DRUG: Suptavumab 30 mg/kg - 2 Doses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anal Sphincter Prosthesis in Treating Patients Who Are Undergoing Surgery for Anal or Rectal Cancer
Status: COMPLETED
Conditions: Anal Cancer|Colorectal Cancer|Perioperative/Postoperative Complications
Interventions: PROCEDURE: conventional surgery|PROCEDURE: management of therapy complications
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Residence Time Evaluation of Marketed OTC Ophthalmic Products
Status: COMPLETED
Conditions: Dry Eye
Interventions: OTHER: Systane Ultra Lubricant Eye Drops|OTHER: Unisol 4 Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Sacral Nerve Stimulation Before Definitive Implantation
Status: WITHDRAWN
Conditions: Fecal Incontinence
Interventions: PROCEDURE: sacral nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Approach to Lysis Utilizing Eptifibatide and rt-PA in Acute Ischemic Stroke (CLEAR Stroke) Trial
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: activase|DRUG: integrilin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of PLDD Versus ESI in the Treatment of Lumbar Radicular Pain
Status: RECRUITING
Conditions: Herniated Disc|Low Back Pain
Interventions: PROCEDURE: Epidural Steroid Injection|PROCEDURE: Percutaneous Laser Disc Decompression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sperm Retrieval Rates in Non-obstructive Azoospermic Men Subjected to Gonadotropin Therapy
Status: COMPLETED
Conditions: Non-obstructive Azoospermia|Hormone Deficiency|Hypogonadism, Male|Male Infertility
Interventions: DRUG: Hormonal Therapy Agent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety and Tolerance of SYHX1903 in Patients With Relapsed/Refractory Hematologic Malignancies
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia|Lymphoma|Multiple Myeloma
Interventions: DRUG: SYHX1903
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Neoadjuvant Chemotherapy With Weekly Paclitaxel or Eribulin Followed by A/C in Women With Locally Advanced HER2-Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|HER2-negative Breast Cancer
Interventions: DRUG: Paclitaxel|DRUG: Eribulin|DRUG: Doxorubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium Assessment
Status: COMPLETED
Conditions: Acute Heart Failure|Diuretics Drug Reactions
Interventions: DIAGNOSTIC_TEST: UNa measurement after intravenous loop diuretic bolus|DRUG: Intravenous acetazolamide 500 mg OD|DRUG: Intravenous bumetanide TID|DRUG: Oral chlorthalidone OD|DRUG: Intravenous canrenoate 200 mg OD|OTHER: Maintenance infusion|DRUG: Oral potassium supplements|OTHER: Intravenous hypertonic saline|OTHER: Switch to oral diuretic therapy|OTHER: Usual AHF care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COmplex BifuRcation Lesions: A Comparison Between the AXXESS Device and Culotte Stenting: An Optical Coherence Tomography (OCT) Study
Status: WITHDRAWN
Conditions: Coronary Artery Stenosis
Interventions: DEVICE: AXXESS Biolimus A9-eluting bifurcation stent|DEVICE: culotte stenting (Xience V)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide and Prednisone in Treating Patients With Myelofibrosis
Status: COMPLETED
Conditions: Essential Thrombocythemia|Polycythemia Vera|Primary Myelofibrosis
Interventions: DRUG: lenalidomide|DRUG: prednisone|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Testing of imHere4U: A Digital Suicide Prevention Intervention for Cyberbullied Adolescents
Status: RECRUITING
Conditions: Psychological Distress|Suicidal Ideation
Interventions: BEHAVIORAL: Flourish|BEHAVIORAL: Questionnaires of Online Experiences
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of COVID-19 by Nebulization of Inteferon Beta 1b Efficiency and Safety Study
Status: COMPLETED
Conditions: COVID-19|INTERFERON|NEBULIZATION
Interventions: DRUG: inhaled type I interferon|DRUG: WFI water nebulization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Doxycycline in Relapsed NHL
Status: TERMINATED
Conditions: Adult Diffuse Large B-Cell Lymphoma|Mantle Cell Lymphoma Recurrent|Lymphoma, Follicular|Marginal Zone B-Cell Lymphoma|Malignant Lymphoma - Lymphoplasmacytic|Waldenstrom Macroglobulinemia|Small Lymphocytic Lymphoma|Chronic Lymphocytic Leukemia (CLL)|T-Cell Lymphoma
Interventions: DRUG: Doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parents Make the Difference II: Trial of a Parenting Intervention
Status: COMPLETED
Conditions: Parenting|Child Abuse
Interventions: BEHAVIORAL: Parents Make the Difference|BEHAVIORAL: Parents Make the Difference Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Topical Loperamide Gel for Pain Reduction During Repeat Finger Lancing
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Loperamide|DRUG: Drug, placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ravulizumab in Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplant
Status: RECRUITING
Conditions: Thrombotic Microangiopathy
Interventions: BIOLOGICAL: Ravulizumab|OTHER: Placebo|OTHER: Best supportive care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.
Status: RECRUITING
Conditions: Chronic Graft Versus Host Disease
Interventions: DRUG: Belumosudil|DRUG: Placebo|DRUG: Prednisone|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anterior Resin Bonded Restorations for Adolescent
Status: ACTIVE_NOT_RECRUITING
Conditions: Missing Teeth
Interventions: PROCEDURE: resin bonded bridge with no preparation|PROCEDURE: resin bonded bridge with minimal preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ranibizumab in Combination With Photodynamic Therapy for Wet Age-Related Macular Degeneration
Status: UNKNOWN
Conditions: Macular Degeneration|Visual Acuity
Interventions: DRUG: Ranibizumab|DRUG: Ranibizumab|DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vismodegib Combined With Atezolizumab in Platinum Resistant Ovarian, Fallopian Tube, and Primary Peritoneal Cancer
Status: RECRUITING
Conditions: Platinum-Resistant Fallopian Tube Carcinoma|Platinum-Resistant Primary Peritoneal Carcinoma|PARP Inhibitor|Hedgehog Inhibitor
Interventions: DRUG: Vismodegib|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nimotuzumab Combined With Chemoradiotherapy Versus Chemoradiotherapy for Local Advanced Cervical Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Cervical Squamous Cell Carcinoma
Interventions: DRUG: Nimotuzumab|DRUG: Cisplatin|RADIATION: External-beam radiation|RADIATION: Brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiolabeled Monoclonal Antibody Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: filgrastim|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: indium In 111 monoclonal antibody BrE-3|RADIATION: yttrium Y 90 monoclonal antibody BrE-3
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: EMR Versus ESD for Barrett's Neoplasia
Status: NOT_YET_RECRUITING
Conditions: Barretts Esophagus With Dysplasia|Barrett Adenocarcinoma|Esophageal Cancer
Interventions: OTHER: EMR|OTHER: ESD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smart Phone Delivered Cognitive Behavioral Therapy for Adults With Psoriasis and Co-Morbid Depression Symptoms
Status: RECRUITING
Conditions: Psoriasis|Depressive Symptoms
Interventions: OTHER: Coach-guided smartphone delivered CBT program.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Investigation Evaluating Safety and Efficacy of Selective Intra-arterial 166Holmium Radiation Therapy in Combination With Atezolizumab and Bevacizumab for Non Resectable Hepatocellular Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DEVICE: QuiremSpheres
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-blinded Placebo-controlled Study to Investigate Antimicrobial Efficacy and Safety Following Topical Application of DPK-060
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: DPK-060 1% ointment|DRUG: Placebo for DPK-060 ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Case Management of Complex Pluripathology in Primary Care
Status: NOT_YET_RECRUITING
Conditions: Complex and Chronic Pluripathology
Interventions: OTHER: Community Nurse Case Manager (CNCM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Patient Specific Plates Versus Conventional Miniplates for Treatment of Mandibular Body Fractures
Status: UNKNOWN
Conditions: Mandibular Fractures
Interventions: DEVICE: Computer guided patient specific 3D titanium plate|DEVICE: Conventional titanium miniplates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-C1s, Anti-HMGB1 and Anti-C1q Autoantibodies in Systemic Lupus Erythematosus (DYSALARM-322)
Status: RECRUITING
Conditions: Lupus Erythematosus, Systemic
Interventions: OTHER: Autoantibodies evaluation in lupus
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Antidepressant Treatment of Mexican-Americans: UCLA Pharmacogenetics and Pharmacogenomics Research Group
Status: COMPLETED
Conditions: Major Depressive Disorder|Major Depression|Unipolar Depression
Interventions: DRUG: fluoxetine or desipramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of KN046 in Subjects With Locally Advanced or Metastatic Triple-negative Breast Cancer
Status: COMPLETED
Conditions: Triple-negative Breast Cancer
Interventions: BIOLOGICAL: KN046|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction TPN Followed by Nivolumab With Radiation in Locoregionally Advanced Laryngeal and Hypopharyngeal Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: Nivolumab|DRUG: Cisplatin|DRUG: Docetaxel|RADIATION: Intensity-modulated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiological Changes Induced Through MEP Conditioning in People With SCI
Status: RECRUITING
Conditions: Spinal Cord Injuries|Neurological Injury|Paralysis|Spasticity, Muscle
Interventions: COMBINATION_PRODUCT: Operant Conditioning|COMBINATION_PRODUCT: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 2
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: DRUG: Nicotine|OTHER: Experimental Flavor|OTHER: Menthol Flavor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Post-market, Randomized, Controlled, Prospective Study Evaluating Intrathecal Pain Medication (IT) Versus Conventional Medical Management (CMM) in the Non-cancer, Refractory, Chronic Pain Population
Status: COMPLETED
Conditions: Chronic Nonmalignant Pain|Pain, Intractable|Pain, Chronic
Interventions: DEVICE: Flowonix Prometra® II Programmable Infusion System|DRUG: Pain Medicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Tissue Removal Assessment With Ultrasound of THe SFA and Popliteal
Status: COMPLETED
Conditions: Peripheral Artery Disease|PAD|Claudication|Peripheral Vascular Disease|PVD
Interventions: DEVICE: Stealth 360°® OAS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concussion Symptom Treatment and Education Program (C-STEP) in Post-Concussion Syndrome
Status: RECRUITING
Conditions: Post-Concussion Syndrome
Interventions: BEHAVIORAL: Usual Care|BEHAVIORAL: C-STEP (Cognitive Behavioral Therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Reusable Soft Contact Lenses
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Control Lenses (comfilcon A with current process)|DEVICE: Test Lenses (comfilcon A with novel process)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Clinical Application of Transcranial Low Intensity Focused Ultrasonic Stimulation for Patients With Major Deperessive Disorder - Exploratory Clinical Trial
Status: COMPLETED
Conditions: Major Depressive Disorder(MDD)
Interventions: PROCEDURE: Active stimulation group Sham stimluation group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short-term Effect of Extended-release Niacin on Endothelial Function.
Status: COMPLETED
Conditions: Hypoalphalipoproteinemia
Interventions: DRUG: Niacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of an App Based on Artificial Intelligence for Purulent AOM Diagnosis in a Pediatric Department
Status: COMPLETED
Conditions: Otitis Media, Suppurative
Interventions: OTHER: AOM diagnosis with app|OTHER: AOM diagnosis without app
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: When to Start Anti-HIV Drugs in Children Infected With HIV (The PREDICT Study)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Abacavir|DRUG: Efavirenz|DRUG: Lamivudine|DRUG: Lopinavir/Ritonavir|DRUG: Nelfinavir|DRUG: Nevirapine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Find and Investigate a Safe Dose of F16IL2 and BI 836858 in Patients With AML Relapse After Allogeneic Hematopoietic Stem Cell Transplantation
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML) Relapse
Interventions: DRUG: F16IL2|DRUG: BI 836858
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cosmetic Result/Toxicity in Post-Mastectomy Immediate Reconstruction Expander+RT
Status: COMPLETED
Conditions: Breast Cancer
Interventions: RADIATION: post-mastectomy radiation therapy (PMRT)|DEVICE: tissue expander (TE)|DEVICE: acellular dermal matrix (ADM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Clinical Trial Immunizing Healthy Adults With the NMRC-M3V-Ad-PfCA Vaccine to Generate Biologic Reagents
Status: WITHDRAWN
Conditions: Healthy|Malaria
Interventions: BIOLOGICAL: Ad-PfCA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Improving HIV Prevention Skills in People With Serious Mental Illnesses
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: BEHAVIORAL: Skill-Building (SB) plus Motivational Interviewing|BEHAVIORAL: Skill-Building (SB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of Radioembolization in Combination With Durvalumab in Locally Advanced and Unresectable HCC
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Durvalumab|RADIATION: Radioembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindful Awareness Program for the Prevention of Dementia: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Dementia
Interventions: BEHAVIORAL: Mindful Awareness Program|BEHAVIORAL: Health Education Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Trial Assessing Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ZP7570
Status: RECRUITING
Conditions: Safety and Tolerability
Interventions: DRUG: ZP7570|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Triple Target Treatment (3T) Which Combines Stimulation With Amplitude Modulated Middle Frequency (AM-MF), Electromyography (EMG)-Triggered Stimulation and EMG-Biofeedback Compared With EMG-Biofeedback in Anal Incontinence
Status: COMPLETED
Conditions: Fecal Incontinence
Interventions: DEVICE: Combination of EMG-biofeedback plus EMG-triggered AM-MF-stimulation|DEVICE: EMG-biofeedback alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open, Single-center Study to Determine the Antibody Repsonse to Gastrimmune and Its Safety and Tolerability in Patients With Advanced Pancreatic Carcinoma
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: G17DT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the O'Neil Long Acting Naltrexone Implant in Opioid Dependent Persons
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder
Interventions: DRUG: naltrexone implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Triple Aim Psychotherapy: Aimed at Improving Patient Experience, Population Health, and Cost
Status: UNKNOWN
Conditions: Anxiety Symptoms|Depressive Symptoms
Interventions: BEHAVIORAL: Cognitive Behaviour Therapy|BEHAVIORAL: Adaptive Psychological Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyponatremia in the Prevention of Hospitalized Patients Falls
Status: COMPLETED
Conditions: Hyponatremia|Accidental Falls
Interventions: OTHER: Early detection and treatment of hyponatremia|OTHER: No Intervention (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Different Nerve Stimulation Methods in Individuals With Chronic Constipation
Status: COMPLETED
Conditions: Constipation
Interventions: DEVICE: Auricular vagus stimulation|DEVICE: Tibial Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Driving Pressure-guided Positive End-expiratory Pressure to Prevent Postoperative Atelectasis in Obese Children: a Prospective, Randomized Controlled Clinical Trial
Status: RECRUITING
Conditions: Driving Pressure|Positive End-expiratory Pressure|Postoperative Atelectasis|Obese
Interventions: OTHER: Driving pressure-guided positive end-expiratory pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Glasdegib-Based Treatment Combinations for the Treatment of Patients With Relapsed Acute Myeloid Leukemia Who Have Undergone Hematopoietic Cell Transplantation
Status: WITHDRAWN
Conditions: Recurrent Acute Myeloid Leukemia
Interventions: DRUG: Bosutinib Monohydrate|DRUG: Decitabine|DRUG: Enasidenib Mesylate|DRUG: Gilteritinib Fumarate|DRUG: Glasdegib Maleate|DRUG: Ivosidenib|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of OPA-15406 Ointment in Pediatric Patients With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: OPA-15406|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Turmeric Supplementation on Polyp Number and Size in Patients With Familial Adenomatous Polyposis.
Status: UNKNOWN
Conditions: Familial Adenomatous Polyposis|FAP|FAP Gene Mutation
Interventions: DIETARY_SUPPLEMENT: Wholistic Turmeric capsules|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Observational Study to Learn More About How Well a Treatment Works When Given After Treatment With Atezolizumab and Bevacizumab or Another Similar Combination of Drugs in Adults With Liver Cancer That Cannot be Treated With Surgery
Status: RECRUITING
Conditions: Unresectable Hepatocellular Carcinoma
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab|DRUG: Durvalumab|DRUG: Tremelimumab,
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Interest of Self-compression Technique on Tolerance of Mammography
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: mammography according to an auto-compression procedure|OTHER: mammography according to a standard procedure|OTHER: questionary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination of Inhaled DNase, Baricitinib and Tocilizumab in Severe COVID-19
Status: UNKNOWN
Conditions: COVID-19 Severe Respiratory Failure
Interventions: DRUG: Dexamethasone|DRUG: Low molecular weight heparin|DRUG: Anakinra 100Mg/0.67Ml Inj Syringe|DRUG: Tocilizumab|DRUG: Baricitinib|DRUG: Dornase Alfa Inhalant Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Results of Randomized Prospective Comparison of Onlay and Sublay Mesh Repair Techniques for Incisional Hernia
Status: COMPLETED
Conditions: Incisional Hernia
Interventions: PROCEDURE: onlay mesh hernioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Efficacy of the REThink Emotions Platform in a Full-scale SMART Study
Status: COMPLETED
Conditions: Emotional Regulation
Interventions: OTHER: REThink Game|OTHER: MoodWheel|OTHER: PsyPills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Pegylated Liposomal Doxorubicin, Low Freq Dexamethasone & Revlimid (Dd-R) in Newly Diagnosed Multiple Myeloma (MM)
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide|DRUG: Pegylated Liposomal Doxorubicin (PLD)|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Randomized, Double-Blind Controlled Study of WPP-201 for the Safety and Efficacy of Treatment of Venous Leg Ulcers
Status: COMPLETED
Conditions: Venous Leg Ulcers
Interventions: DRUG: Bacteriophage|DRUG: WPP-201 Bacteriophage|DRUG: Bacteriophages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Image-guided Pleural Biopsy or Medical Thoracosocopy in Diagnosis of Pleural Disease
Status: COMPLETED
Conditions: Diagnosis of Pleural Diseases
Interventions: PROCEDURE: Abrams' needle pleural biopsy (IG-ANPB) versus medical thoracoscopy in the diagnosis of pleural diseases.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Multicomponent Behavioral Sleep Intervention for Insomnia in Older Adults With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Insomnia
Interventions: BEHAVIORAL: Multicomponent Behavioral Sleep Intervention for Insomnia|BEHAVIORAL: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Suture of the Tuberosities in Inverted Prostheses" Implanted for Acute Fractures of the Proximal Humerus?.
Status: NOT_YET_RECRUITING
Conditions: Proximal Humeral Fractures, Reverse Shoulder Prostheses, Tuberosities
Interventions: PROCEDURE: tuberosity suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ezetimibe Plus Simvastatin on Flow-Mediated Brachial Artery Vasoactivity in Subjects With Primary Hypercholesterolemia (Study P03336)
Status: TERMINATED
Conditions: Hypercholesterolemia|Atherosclerosis
Interventions: DRUG: Ezetimibe + Simvastatin|DRUG: Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Alectinib in Combination With Bevacizumab in ALK Positive NSCLC
Status: COMPLETED
Conditions: ALK Gene Rearrangement Positive|Non-Squamous Non-Small Cell Neoplasm of Lung
Interventions: DRUG: Alectinib|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of GTx-024 in Patients With Androgen Receptor-Positive Triple Negative Breast Cancer (AR+ TNBC)
Status: TERMINATED
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: GTx-024
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Needle-free Injection System During Palatal Anesthesia
Status: COMPLETED
Conditions: Pediatric Anesthesia|Local Anesthesia
Interventions: DEVICE: Comfort-in injection system|OTHER: traditional anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VSL#3 Versus Placebo in Increasing the Pathological Major Response Rate in Patients With Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: OTHER: VSL#3|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of Oral CPL304110, in Adult Subjects With Advanced Solid Malignancies
Status: RECRUITING
Conditions: Gastric Cancer|Bladder Cancer|Squamous Non-small Cell Lung Cancer|Cholangiocarcinoma|Sarcoma|Endometrial Cancer|Other Solid Tumours
Interventions: DRUG: CPL304110
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Haptic Interactive Virtual Reality on Nasogastric Tube Practice Teaching
Status: COMPLETED
Conditions: Simulation|Nasogastric Tube
Interventions: OTHER: Traditional Education(control)|OTHER: Haptic interactive virtual reality simulation training|OTHER: Haptic interactive computer-based simulation training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intervention to Improve the Adherence in Community Pharmacies
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease (COPD|Arterial Hypertension|Diabetes Mellitus
Interventions: OTHER: ANM|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: 2-octyl Cyanoacrylate for Closure of Urethrocutaneous Fistula.
Status: COMPLETED
Conditions: Urethrocutaneous Fistulas
Interventions: DEVICE: 2-octylcyanoacrylate|PROCEDURE: Surgical reintervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Voriconazole Versus Itraconazole In Primary Prophylaxis Of Invasive Fungal Infection (IFI) In Subjects With Allogeneic Hematopoietic Stem Cell Transplants (HSCT)
Status: COMPLETED
Conditions: Antifungal Prophylaxis of Invasive Fungal Infections
Interventions: DRUG: Itraconazole|DRUG: Vfend - voriconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Brentuximab Vedotin Plus TAK228 for Relapsed/Refractory Classical Hodgkin Lymphoma, Anaplastic Large Cell Lymphoma and Other CD30+Peripheral T-Cell Lymphomas
Status: WITHDRAWN
Conditions: Malignant Neoplasms Stated as Primary Lymphoid Haematopoietic|Classical Hodgkin Lymphoma|Anaplastic Large Cell Lymphoma|CD30+ Peripheral T-cell Lymphoma
Interventions: DRUG: Brentuximab Vedotin|DRUG: TAK228|DEVICE: Glucose Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents
Status: RECRUITING
Conditions: Metastatic Castration-Sensitive Prostate Cancer
Interventions: DRUG: Saruparib|DRUG: Placebo|DRUG: Abiraterone Acetate|DRUG: Darolutamide|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Xylitol for the Prevention of Acute Otitis Media Episodes in Children
Status: UNKNOWN
Conditions: Acute Otitis Media|URTI|Dental Caries in Children
Interventions: OTHER: Xylitol syrup|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: Ocrelizumab|DRUG: Placebo for Ocrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: JSP191 Antibody Conditioning Regimen in MDS/AML Subjects Undergoing Allogenic Hematopoietic Stem Cell Transplantation
Status: UNKNOWN
Conditions: MYELODYSPLASTIC SYNDROME; MDS|ACUTE MYELOID LEUKEMIA; AML
Interventions: BIOLOGICAL: Humanized anti-CD117 Monoclonal Antibody (JSP191)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CpG 7909 in Treating Patients Who Have Undergone Autologous Stem Cell Transplant
Status: TERMINATED
Conditions: Germ Cell Tumor|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: keyhole limpet hemocyanin|BIOLOGICAL: tetanus toxoid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BGJ398 in Treating Patients With FGFR Positive Recurrent Head and Neck Cancer
Status: TERMINATED
Conditions: FGFR Gene Amplification|FGFR1 Gene Amplification|FGFR2 Gene Amplification|FGFR2 Gene Mutation|FGFR3 Gene Mutation|Head and Neck Squamous Cell Carcinoma|Human Papillomavirus Infection|Recurrent Head and Neck Carcinoma|Recurrent Nasopharynx Carcinoma|Recurrent Oropharyngeal Squamous Cell Carcinoma
Interventions: DRUG: BGJ398
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Asenapine in the Prevention of Recurrence of Mood Episodes in Participants With Bipolar 1 Disorder (P06384)
Status: COMPLETED
Conditions: Bipolar 1 Disorder
Interventions: DRUG: asenapine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study: Paravertebral Analgesia vs Epidural Analgesia After Thoracotomy
Status: TERMINATED
Conditions: Hypotension
Interventions: DRUG: Epidural Catheter 0.2% ropivacaine|DRUG: Paravertebral Catheter 0.4% ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients
Status: WITHDRAWN
Conditions: Pulmonary Hypertension|Neonatal Hypoxic Respiratory Failure|Persistent Pulmonary Hypertension of Newborn|Congenital Heart Defects|Acute Respiratory Distress Syndrome
Interventions: DRUG: Iloprost|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Relationship Between Intraoperative Intravenous Acetaminophen and Postoperative Opioid Avoidance for Ambulatory Surgical Procedures
Status: WITHDRAWN
Conditions: Postoperative Pain|Intraoperative and Postoperative Opioid Requirements
Interventions: DRUG: Intravenous acetaminophen|DRUG: Intravenous placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Necitumumab and Chemotherapy in Participants With Stage IV Squamous Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Squamous Non Small Cell Lung Cancer
Interventions: DRUG: Necitumumab|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Anaphylaxis
Status: ACTIVE_NOT_RECRUITING
Conditions: Anaphylaxis|Allergy|Transfusion Reaction|Febrile Transfusion Reaction
Interventions: DIAGNOSTIC_TEST: Biomarkers (platelet activating factor [PAF], anaphylatoxins) and basophil activation test (BAT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Facilitating Smoking Cessation With Reduced Nicotine Cigarettes
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Very Low Nicotine Content (VLNC) Cigarettes|BEHAVIORAL: One on One Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Safety and Effectiveness of Zidovudine Plus Lamivudine, Used With and Without 1592U89, in HIV-1 Infected Children Who Have Taken Anti-HIV-1 Drugs
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Abacavir sulfate|DRUG: Lamivudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: A Trial of an Investigational Drug for the Prevention of Diarrhea Associated With Irinotecan/5FU/Leucovorin Chemotherapy in Previously Untreated Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Neoplasms|Diarrhea
Interventions: DRUG: Investigational drug|DRUG: Irinotecan|DRUG: 5-fluorouracil|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: New Mechatronic Device for Epidural Space Detection
Status: COMPLETED
Conditions: Non Invasive Monitoring of Loss of Resistance During Epidural Injection
Interventions: DEVICE: LOR measurement via device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Improving SWAllowing After Stroke With Transcranial Direct Current Stimulation
Status: TERMINATED
Conditions: Acute Stroke|Dysphagia
Interventions: DEVICE: transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: General vs Spinal Anesthesia for Total Joint Arthroplasty-Anterior Approach: A Single-Institution Observational Study
Status: COMPLETED
Conditions: Arthroplasty Complications|Anesthesia
Interventions: PROCEDURE: Total Hip Arthroplasty|PROCEDURE: General Anesthesia|PROCEDURE: Spinal Anesthesia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preoperative Treatment With Noninvasive Intra-auricular Vagus Nerve Stimulation Pending Bariatric Surgery
Status: TERMINATED
Conditions: Obesity|Bariatric Surgery
Interventions: DEVICE: NeuroCoach II Stim|DEVICE: NeuroCoach II Stim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vibration Therapy as an Intervention for Enhancing Trochanteric Hip Fracture Healing in Elderly Patients
Status: RECRUITING
Conditions: Hip Fractures
Interventions: DEVICE: Low-magnitude high-frequency vibration (LMHFV)|DEVICE: Low-magnitude high-frequency vibration (LMHFV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT