pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Multi-center, Randomized, Double-blind, Placebo-controlled, Multiple Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of Subcutaneously Delivered ASLAN004 in Adults With Moderate-Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: ASLAN004|DRUG: ASLAN004 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Social Anxiety Disorder and Selective Mutism
Status: COMPLETED
Conditions: Social Anxiety Disorder|Selective Mutism
Interventions: BEHAVIORAL: Taming Sneaky Fears|BEHAVIORAL: Parent Psycho-education and Child Socialization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immersive Virtual Reality to Improve Gait in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease|Gait Disorders, Neurologic
Interventions: OTHER: Treadmill + VR|OTHER: Treadmill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Shared Decision Aid for Post-Total Knee Arthroplasty Opioid Prescribing
Status: UNKNOWN
Conditions: Knee Arthroplasty, Total|Analgesia|Opioid Use, Unspecified
Interventions: OTHER: Shared Decision Making
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioresorbable Sirolimus-Eluting Scaffold Treatment for Below the Knee Disease
Status: NOT_YET_RECRUITING
Conditions: Chronic Limb-Threatening Ischemia
Interventions: DEVICE: MAGNITUDE Sirolimus-eluting Bioresorbable Scaffold|DEVICE: Percutaneous Transluminal Angioplasty (PTA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Targeting Cerebellum to Treat Psychosis: a Transcranial Magnetic Stimulation (TMS) Study
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Bipolar Disorder I
Interventions: DEVICE: Excitatory TMS|DEVICE: Inhibitory TMS|DEVICE: Sham TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Brodalumab Compared With Placebo and Ustekinumab in Moderate to Severe Plaque Psoriasis Subjects
Status: TERMINATED
Conditions: Plaque Psoriasis
Interventions: DRUG: 210 mg brodalumab|DRUG: 140 mg brodalumab|DRUG: ustekinumab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dementia Risk and Dynamic Response to Exercise
Status: COMPLETED
Conditions: Alzheimer Disease 2 Due to Apoe4 Isoform|Healthy Aging
Interventions: BEHAVIORAL: Moderate Intensity Aerobic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Evaluating Oxybutynin in Patients With Neurogenic Overactive Bladder Associated With a Neurological Condition
Status: COMPLETED
Conditions: Detrusor Hyperreflexia
Interventions: DRUG: Oxybutynin transdermal system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Field Testing of Ready-to-use-therapeutic Foods Made of Local Ingredients in Bangladesh for SAM Children
Status: COMPLETED
Conditions: Severe Acute Malnutrition in Childhood
Interventions: DIETARY_SUPPLEMENT: RUTF-1|DIETARY_SUPPLEMENT: RUTF-2|DIETARY_SUPPLEMENT: Plumpynut
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Cholinergic Signaling for Mediating the Effects of GIP and/or Xenin-25 on Insulin Secretion
Status: COMPLETED
Conditions: Pre-diabetes
Interventions: DRUG: Control|DRUG: Xenin-25 without atropine|DRUG: GIP without atropine|DRUG: Placebo with atropine|DRUG: Xenin-25 with atropine|DRUG: GIP with atropine|DRUG: GIP plus Xenin-25 without atropine|DRUG: GIP plus Xenin-25 with atropine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Fractional CO2 Laser Treatment Efficacy and Comparison to Vaginal Estrogen Therapy in Postmenopausal Women With Vulvovaginal Atrophy
Status: COMPLETED
Conditions: Vulvovaginal Atrophy
Interventions: DEVICE: CO2 laser|DRUG: Estrogen|DRUG: Placebo of Estrogen|DEVICE: Placebo of CO2 laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Cancer Biospecimen Collection Study
Status: RECRUITING
Conditions: Cancer of Head and Neck|Lung Cancer, Nonsmall Cell|Small-cell Lung Cancer|Urothelial Carcinoma|Gastroesophageal Junction Adenocarcinoma|Cervical Cancer|Esophageal Squamous Cell Carcinoma|Triple Negative Breast Cancer|Hepatocellular Carcinoma|Renal Cell Carcinoma|Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: OncoPrism™ assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant Depression
Status: COMPLETED
Conditions: Depressive Disorder, Treatment-Resistant
Interventions: DRUG: MIJ821|DRUG: Placebo|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Action Observation Therapy and Mirror Therapy in Children With Unilateral Cerebral Palsy
Status: NOT_YET_RECRUITING
Conditions: Cerebral Palsy|Functioning|Upper Extremity Problem
Interventions: OTHER: Action Observation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Novel Technology to Support Tailored Health Behavior Counseling in Rural Primary Care Clinics
Status: NOT_YET_RECRUITING
Conditions: Cardiovascular Diseases|Obesity
Interventions: BEHAVIORAL: Wait-List Control|BEHAVIORAL: PREVENT Tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparative Study of the Immunogenicity of MMR (Measles, Mumps and Rubella) Single Dose and Multidose Presentations
Status: COMPLETED
Conditions: Measles|Mumps|Rubella
Interventions: BIOLOGICAL: MMR Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Efficacy and Safety of Lemborexant in Subjects 55 Years and Older With Insomnia Disorder (SUNRISE 1)
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: Lemborexant|DRUG: Lemborexant|DRUG: Lemborexant-matched placebo|DRUG: Zolpidem tartrate|DRUG: Zolpidem-matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: the Gastric Bypass Stent System as a Treatment for Hepatic Fibrosis in Obese Patients in European Region
Status: RECRUITING
Conditions: Fibrosis|Liver
Interventions: DEVICE: Gastric Bypass Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRELUDE Study of Lymphatic Surgery to Treat Breast Cancer Related Lymphoedema
Status: RECRUITING
Conditions: Breast Cancer|Lymphedema
Interventions: PROCEDURE: Lymphaticovenous anastomosis surgery combined with near infrared spectroscopy imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastric Emptying and Insulin Response to Test Drink
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: OTHER: Carbohydrate based drink|OTHER: Whey protein based drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Abemaciclib With or Without Atezolizumab for mCRPC
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer|Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: Abemaciclib|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction Study of "CG100650" in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Polmacoxib and Tramadol combination|DRUG: Polmacoxib|DRUG: Tramadol hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Benign Hysterectomy
Status: COMPLETED
Conditions: Menorrhagia|Metrorrhagia|Uterine Fibroids|Cervical Dysplasia
Interventions: DEVICE: Robotic hysterectomy|PROCEDURE: Vaginal or laparoscopic hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of GSK3640254 on the Pharmacokinetics of Tenofovir Alafenamide/Emtricitabine
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Tenofovir alafenamide/emtricitabine|DRUG: GSK3640254
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Riociguat Clinical Effects Studied in Patients With Insufficient Treatment Response to Phosphodiesterase-5 Inhibitor
Status: COMPLETED
Conditions: Hypertension, Pulmonary
Interventions: DRUG: Riociguat (Adempas, BAY63-2521)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Protocol for Dose Reduction in Patients With Spondylarthropathies and Clinical Remission With Anti-TNF
Status: COMPLETED
Conditions: Spondylarthropathies
Interventions: DRUG: Reduced doses of anti-TNF|DRUG: Stable doses of anti-TNF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Precision Adjuvant Therapy After Surgery for Hepatocellular Carcinoma
Status: RECRUITING
Conditions: HCC
Interventions: DRUG: PD-1 monoclonal antibody and lenvatinib|DRUG: PD-1 monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Valeo OL Interbody Fusion Devices for Posterior Lumbar Interbody Fusion SNAP Trial
Status: COMPLETED
Conditions: Disc Degeneration of Pfirrmann Grade III or Greater|Degenerative Spondylolisthesis|Isthmic Spondylolisthesis of Grade I or II
Interventions: DEVICE: Posterior lumbar interbody fusion with a PEEK cage|DEVICE: Posterior lumbar interbody fusion with a Valeo OL cage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of the Cionic Neural Sleeve on Mobility in Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis|Multiple Sclerosis, Relapsing-Remitting|Multiple Sclerosis, Chronic Progressive
Interventions: DEVICE: Cionic Neural Sleeve NS-100|DEVICE: Actigraph accelerometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic (PK) Study to Compare the Absorption of Two Formulations of Transdermal Testosterone Spray and Intrinsa®
Status: TERMINATED
Conditions: Hypoactive Sexual Desire Disorder
Interventions: DRUG: Testosterone Spray 5% and 1%|DRUG: Intrinsa® Patch and Testosterone Spray 5%|DRUG: Intrinsa® Patch and Testosterone Spray 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Detection of SARS-CoV-2 in Semen of COVID-19 Positive Males
Status: UNKNOWN
Conditions: COVID-19|Sars-CoV2|Corona Virus Infection|Semen
Interventions: DIAGNOSTIC_TEST: Ejaculated semen sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of Lower Right Limb Orthopedic Immobilization on Driving Performance
Status: COMPLETED
Conditions: Walking Cast Right Leg Immobilisation Effects|Aircast Right Leg Immobilisation Effects
Interventions: PROCEDURE: Driving with running shoes|PROCEDURE: Plaster cast|PROCEDURE: Driving with Aircast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Quantitative Flow Ratio (QFR) Guided Revascularization Strategy for Patients Undergoing Primary Valve Surgery With Comorbid Coronary Artery Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Valvular Heart Disease With Comorbid Coronary Artery Disease|Planned to Undergo Elective On-pump Valve Surgery Due to Primary Mitral and/or Aortic Valvular Heart Disease
Interventions: DEVICE: QFR-guided strategy|OTHER: CAG-guided strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ankle Kinesio Taping vs Mulligan's Mobilization With Movement
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Kinesio-tape|OTHER: Mulligan's mobilization with movement|OTHER: Sham Kinesio-taping|OTHER: Sham Mulligan's mobilization with movement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oophorectomy, Estrogen Therapy and Cardiovascular Disease Risk in Young Women
Status: COMPLETED
Conditions: Cardiovascular Risk Reduction
Interventions: DRUG: Estradiol 100 Micrograms Patch|DRUG: Estradiol Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of the Nile PAX Drug-Eluting Coronary Bifurcation Stent
Status: COMPLETED
Conditions: Coronary Disease
Interventions: DEVICE: Nile PAX® paclitaxel-eluting coronary stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DEPO-Trigger Trial: GnRH Agonist DEPOt TRIGGER for Final Oocyte Maturation
Status: RECRUITING
Conditions: Breast Cancer Female
Interventions: DRUG: Triptorelin 3.75 MG Injection|PROCEDURE: Transvaginal oocyte retrieval|DRUG: Triptorelin Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Proportioning Meat and Plant-based Protein-rich Foods on Cardiovascular Disease Risk Factors (S58)
Status: COMPLETED
Conditions: Healthy Diet|Cardiovascular Risk Factor
Interventions: OTHER: High RM, low NSS|OTHER: Moderate RM, Moderate NSS|OTHER: Low RM, High NSS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Comparison of the Effects of Gelatine Versus Balanced Crystalloid Solution for Volume Therapy
Status: UNKNOWN
Conditions: Hemorrhage, Surgical|Hip Replacement, Total|Thrombocytopathy
Interventions: DRUG: Gelofusine® B. Braun|DRUG: Ringerfundin ® B. Braun
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Different Intraocular Lenses Implanted With Yamane Technique
Status: RECRUITING
Conditions: Secondary Cataract Surgery|Aphakia|Complicated Cataract Surgery
Interventions: DEVICE: IOL Master 700|DEVICE: Casia-2|DEVICE: MS-39|DEVICE: OSIRIS|DEVICE: Autorefractor|DIAGNOSTIC_TEST: Subjective Refraction|DIAGNOSTIC_TEST: Biomicroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tolerance for Using Virtual Reality With Subjects Living in Accommodation Establishment for the Elderly Dependent (EHPAD)
Status: COMPLETED
Conditions: Anxiety Disorders|Residents of Retirement Home (EHPAD)
Interventions: DEVICE: virtual reality headset "Occulus GO"
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Single and Multiple Ascending and Food Effect Study of RP7214, a DHODH Inhibitor in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: RP7214|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of HST5040 in Subjects With Propionic or Methylmalonic Acidemia
Status: TERMINATED
Conditions: Methylmalonic Acidemia|Propionic Acidemia
Interventions: DRUG: HST5040|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Exenatide in Coronary Intensive Care Unit (ICU) Patients
Status: COMPLETED
Conditions: Hyperglycemia|Acute Coronary Syndromes|Myocardial Infarction
Interventions: DRUG: Exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Preliminary Efficacy Pharmacokinetics and Immunogenicity of BMS-188667 Administered to Subjects With Relapsing-remitting Multiple Sclerosis
Status: TERMINATED
Conditions: Multiple Sclerosis
Interventions: DRUG: Placebo|DRUG: BMS 188667 (Abatacept)|DRUG: BMS 188667 (Abatacept)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy Using CAR T-cells to Target CD19 for Relapsed/Refractory CD19+ Primary CNS Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary CNS Lymphoma
Interventions: BIOLOGICAL: CD19CAR T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Therapeutic Regimens for Scleroderma Interstitial Lung Disease (The Scleroderma Lung Study II)
Status: COMPLETED
Conditions: Scleroderma|Interstitial Lung Disease
Interventions: DRUG: Mycophenolate mofetil|DRUG: Cyclophosphamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-PD 1 Brain Collaboration + Radiotherapy Extension (ABC-X Study)
Status: RECRUITING
Conditions: Melanoma Stage Iv
Interventions: DRUG: Ipilimumab|DRUG: Nivolumab|RADIATION: Stereotactic Radiotherapy|OTHER: Salvage therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ceftobiprole's Cerebrospinal Fluid Penetration in Patients With External Ventricular Derivation (CEFTO-EVD)
Status: UNKNOWN
Conditions: Pharmacokinetics|Cerebral Ventriculitis|Cephalosporins|Cerebrospinal Fluid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TBE Antibody Persistence and Booster Vaccination Study in Adults (Follow-up to Study 223)
Status: COMPLETED
Conditions: Encephalitis, Tick-Borne
Interventions: BIOLOGICAL: Tick-Borne Encephalitis (TBE) Vaccine (Inactivated)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: BNP for Cardio-Renal Decompensation Syndrome (BNP-CARDS)
Status: COMPLETED
Conditions: Congestive Heart Failure Exacerbation|Renal Insufficiency
Interventions: DRUG: Natrecor, a recombinant form of B-type Natriuretic Peptide, made by Scios, Inc. vs. placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Male Subjects to Investigate Whether Administration of ACT-132577 Can Affect Rosuvastatin's Fate in the Body (Amount and Time of Presence in the Blood)
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Aprocitentan|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: 24-week Placebo-controlled Trial of Flibanserin Once Daily in Premenopausal Women With Hypoactive Sexual Desire Disorder
Status: COMPLETED
Conditions: Sexual Dysfunctions, Psychological
Interventions: DRUG: flibanserin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Respiratory Health Study of Children in Kiryat Tivon
Status: COMPLETED
Conditions: Bronchial Asthma|Signs and Symptoms, Respiratory|Allergy
Interventions: DEVICE: Minato A 500 AS spirometer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Relative Bioavailability of a Modified-Release Formulation of PF-05180999
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-05180999|DRUG: PF-05180999|DRUG: PF-05180999|DRUG: PF-05180999
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Gene Modified Autologous Hematopoietic Stem Cells to Treat Transfusion-dependent Beta-thalassemia
Status: RECRUITING
Conditions: β-thalassemia
Interventions: GENETIC: BD211
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cannabis for Spasticity in Multiple Sclerosis
Status: TERMINATED
Conditions: Multiple Sclerosis
Interventions: DRUG: Inhaled Cannabis|DRUG: Oral THC|DRUG: Oral Placebo|DRUG: Inhaled placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Mindfulness In Musculoskeletal Tumor
Status: WITHDRAWN
Conditions: Musculoskeletal Malignancy
Interventions: BEHAVIORAL: Personalized acceptance-based mindfulness exercise|BEHAVIORAL: Brief educational pamphlet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SBRT Combined With Zimberelimab (GLS-010) in Locally Advanced Pancreatic Cancer (SPARK-1 Study)
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Pancreatic Cancer
Interventions: RADIATION: Stereotactic body radiation(SBRT)|DRUG: Zimberelimab (GLS-010)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of AFQ056 in Adult Patients With Fragile X Syndrome
Status: COMPLETED
Conditions: Fragile X Syndrome
Interventions: DRUG: AFQ056|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vardenafil Orodispersible Tablet (ODT) Versus Placebo in Males With Erectile Dysfunction, 50% of Whom Are to be 65 Years or Older.
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Vardenafil ODT (STAXYN, BAY38-9456)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Cariostatic Effect of Nano-Silver Fluoride Versus Silver Diamine Fluoride
Status: NOT_YET_RECRUITING
Conditions: Dental Caries in Children
Interventions: DRUG: Nano-Silver Fluoride|DRUG: Silver diamine fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Connective Tissue Manipulation on Pelvic Floor Muscle Functions in Children
Status: COMPLETED
Conditions: Lower Urinary Tract Symptoms
Interventions: OTHER: Urotherapy|OTHER: Diaphragmatic Breathing Exercises|OTHER: PFM Exercises|OTHER: Connective Tissue Manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Aerobic Interval Training on Atrial Fibrillation Burden
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation|Cardiac Rehabilitation
Interventions: OTHER: high-intensity interval training|OTHER: moderate-intensity interval training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety & Interaction Between GW679769, Dexamethasone, & Ondansetron When Taken by Healthy Adults
Status: COMPLETED
Conditions: Nausea and Vomiting, Chemotherapy-Induced
Interventions: DRUG: Casopitant (GW679769) Oral Tablets|DRUG: dexamethasone|DRUG: ondansetron
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Endostar Combined With Chemotherapy Followed by Endostar Maintenance Therapy to Treat Advanced Non-small Cell Lung Cancer (NSCLC)
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: DRUG: Endostar|DRUG: Gemcitabine-Cisplatin chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vicriviroc (SCH 417690) Treatment Protocol in Human Immunodeficiency Virus (HIV)-Infected Participants: A Rollover Study for ACTG Protocol A5211 (P04100)
Status: COMPLETED
Conditions: HIV|HIV Infections
Interventions: DRUG: Vicriviroc maleate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Lenacapavir and Emtricitabine/Tenofovir Disoproxil Fumarate (F/TDF) in Prevention of HIV in Cisgender Women in the United States (HPTN 102)
Status: RECRUITING
Conditions: Pre-Exposure Prophylaxis of HIV Infection
Interventions: DRUG: Lenacapavir Tablet|DRUG: Lenacapavir Injection|DRUG: Emtricitabine/Tenofovir Disoproxil Fumarate (F/TDF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Chinese Randomized Crossover Study of Erlotinib Versus Docetaxel/Cisplatin in Previously Untreated Stage IIIB/IV Lung Adenocarcinoma With EGFR Mutations
Status: UNKNOWN
Conditions: Neoplasms, Lung|Carcinoma, Non-Small Cell Lung|Drug Therapy|Genes, EGFR
Interventions: DRUG: Erlotinib|DRUG: Docetaxel|DRUG: Cisplatin|DRUG: Docetaxel|DRUG: Cisplatin|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Reduced 11-b-HSD Activity, a Novel Mechanism of Salt Sensitivity and Hypertension After Renal Allograft Donation?
Status: COMPLETED
Conditions: Renal Failure|Renal Transplantation|Living Donors
Interventions: DIETARY_SUPPLEMENT: Low and high salt diets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Neural Tube Defects by Inositol in Conjunction With Folic Acid (PONTI Study)
Status: COMPLETED
Conditions: Recurrent Neural Tube Defects
Interventions: DRUG: Folic Acid and inositol|DRUG: Folic acid and placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of ARC-520 With or Without Other Drugs Used in the Treatment of Chronic Chronic Hepatitis B Virus (HBV)
Status: TERMINATED
Conditions: Hepatitis B|Hepatitis D
Interventions: DRUG: ARC-520|DRUG: entecavir|BIOLOGICAL: pegylated interferon alpha 2a|DRUG: tenofovir disoproxil|DRUG: antihistamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation After Total Knee Arthroplasty (TKA) - PFC Rotating Versus Fixed Bearing
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: P.F.C. Sigma knee arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of MabThera (Rituximab) Plus Chlorambucil in Participants With Chronic Lymphocytic Leukemia.
Status: COMPLETED
Conditions: Lymphocytic Leukemia, Chronic
Interventions: DRUG: Rituximab|DRUG: Chlorambucil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Myocardial Function in Patients Undergoing LVAD Implantation
Status: COMPLETED
Conditions: Heart Failure|Cardiomyopathy|Ventricular Dysfunction
Interventions: BIOLOGICAL: MPC Intramyocardial injection|BIOLOGICAL: Control Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Switching to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (E/C/F/TAF) Fixed Dose Combination (FDC) in Virologically-Suppressed HIV-1 Infected Adults Harboring the Archived Isolated NRTI Resistance Mutation M184V/M184I
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: E/C/F/TAF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antifungal Potential of Moringa Olifera Against Otomycosis
Status: COMPLETED
Conditions: Otomycosis
Interventions: DRUG: Moringa oleifera leaf 10mg/100ml|DRUG: Ear Drop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential/Combination Therapy in Nucleoside or Nucleotide Analogue (NA)-Suppressed Chronic Hepatitis B Patients
Status: UNKNOWN
Conditions: Chronic Hepatitis b
Interventions: DRUG: Entecavir|DRUG: Granulocyte Macrophage Colony Stimulating Factor|DRUG: Y peginterferon alfa-2b|DRUG: HBV vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Korean Post-marketing Surveillance Vyndamax® Capsules for the Treatment of Transthyretin Amyloid Cardiomyopathy
Status: RECRUITING
Conditions: ATTR-CM (Transthyretin Amyloid Cardiomyopathy)
Interventions: DRUG: Vyndamax (tafamidis 61mg)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intraoral Scanners as Periodontal and Dental Pathologies Diagnosis Tools
Status: RECRUITING
Conditions: Periodontitis|Gingivitis|Dental Caries|Diagnosis
Interventions: OTHER: Numerical dental impression by intraoral scanner
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: H. Pylori Eradication for Moderate ITP
Status: UNKNOWN
Conditions: Immune Thrombocytopenic Purpura|Helicobacter Pylori|Immune Thrombocytopenia
Interventions: DRUG: treatment : H. pylori eradication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Buprenorphine Extended-Release Subcutaneous Injection (RBP-6000) in High-risk Users
Status: COMPLETED
Conditions: Moderate to Severe Opioid-use Disorder
Interventions: DRUG: Transmucosal Buprenorphine|DRUG: Extended-release Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Synchronization of Follicle Wave Emergence and Ovarian Stimulation
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Gonal F|DRUG: Luveris|DRUG: Cetrotide|DRUG: hCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of TAK-906 in Adult Participants With Symptomatic Idiopathic or Diabetic Gastroparesis
Status: COMPLETED
Conditions: Diabetic Gastroparesis|Idiopathic Gastroparesis
Interventions: DRUG: TAK-906 Maleate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Functional MRI Study in Children With a Developmental Coordination Disorder (DCD) and/or Developmental Dyslexia (DD)
Status: COMPLETED
Conditions: Developmental Dyslexia|Developmental Coordination Disorder
Interventions: BEHAVIORAL: Neuropsychological assessment|OTHER: MRI Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.
Status: RECRUITING
Conditions: Triple Negative Breast Cancer|Diffuse Large B Cell Lymphoma|Follicular Lymphoma|Lymphoma, Non-Hodgkin|Mantle Cell Lymphoma|Bladder Cancer|Uveal Melanoma, Recurrent|Cervix Cancer|Carcinoma in Situ|Head and Neck Squamous Cell Carcinoma|Skin Cancer|Metastatic Cancer|Tumor, Solid|Tumor Recurrence
Interventions: DRUG: ONM-501|DRUG: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial Comparing Matt and Antimicrobial Cellomed Laminates
Status: UNKNOWN
Conditions: Cross Infection|Infection Control
Interventions: OTHER: Swabbing of observation chart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Home-based Cardiovascular Rehabilitation, Maintenance Phase, in Subjects With Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Heart Disease|Acute Myocardial Infarction: Rehabilitation Phase
Interventions: PROCEDURE: Cardiovascular rehabilitation program using Kinect of Xbox|PROCEDURE: Cardiovascular rehabilitation program using paper manual|OTHER: Educational component
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zinc and Iron Absorption From Common Beans in Young Adult Women
Status: RECRUITING
Conditions: Zinc Absorption|Iron Absorption
Interventions: OTHER: SER 118|OTHER: LMP 1001|OTHER: LPA 586|OTHER: KAT B1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Inhaled Nitric Oxide (iNO) in Idiopathic Pulmonary Fibrosis (IPF).
Status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Nitric Oxide|DRUG: Medical air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of the Dose Regimen of Oral Vitamin D 50,000 IU in the Treatment of Vitamin D Deficiency
Status: UNKNOWN
Conditions: Vitamin D Deficiency
Interventions: DRUG: 50.000 IU vitamin D3 (Biodal 50,000 IU)|DRUG: Placebo (to mimic Biodal 50,000 IU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ipilimumab vs Ipilimumab Plus Nivolumab in Patients With Stage III-IV Melanoma Who Have Progressed or Relapsed on PD-1 Inhibitor Therapy
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: ipilimumab|DRUG: nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Motivational Interviewing on Problematic Internet Use and Loneliness
Status: ACTIVE_NOT_RECRUITING
Conditions: Problematic Internet Use|Loneliness
Interventions: BEHAVIORAL: Motivational Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: LIPT - Liraglutide in Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Cardiovascular Disease
Interventions: DRUG: Liraglutide for 26 weeks|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Photocil (Topical) for the Treatment of Psoriasis Vulgaris
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Photocil for Psoriasis|OTHER: Placebo - Sunscreen (SPF 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Mobile Smartphone Application to Promote a Healthy Diet and Physical Activity Among Pregnant Women With GDM - RCT
Status: COMPLETED
Conditions: Gestational Diabetes Mellitus
Interventions: OTHER: Pregnant+ app for smartphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Cascade Feasibility Pilot (Ileostomy)
Status: COMPLETED
Conditions: Ileostomy; Complications|Ileostomy - Stoma
Interventions: OTHER: Non-invasive continuous remote monitoring with structured escalation pathway|OTHER: Affective Analysis of Participant Response to Continuous Remote Patient Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Rehabilitation of Patients From the ICU to the Post-hospital Phase
Status: NOT_YET_RECRUITING
Conditions: Early Mobilization|Physiotherapy|Rehabilitation
Interventions: OTHER: Early and intensive mobilization protocol at the ICU and Rehabilitation post-hospital discharge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Magnetic Randomized Trial in Elderly Depressed
Status: UNKNOWN
Conditions: Major Depressive Disorder
Interventions: DEVICE: Transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmaco-epidemiological Study Describing a Population of Hypertensive Patients Treated With a Fixed-dose Combination of Telmisartan and Hydrochlorothiazide
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan and hydrochlorothiazide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Improving Executive Functions After Traumatic Brain Injury (TBI): A Clinical Trial of the "Executive Plus" Program
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: Top Down|OTHER: cognitive rehabilitation day treatment program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Truncal Vagotomy in Patients Undergoing Revisional Sleeve Gastrectomy to Gastric Bypass
Status: NOT_YET_RECRUITING
Conditions: GERD
Interventions: PROCEDURE: Truncal vagotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Visual Cues and Education for People Who Live Within Long Term Care Communities to Assist in Wayfinding
Status: COMPLETED
Conditions: Alzheimer Disease|Alzheimer Dementia|Age-Related Memory Disorders|Dementia
Interventions: BEHAVIORAL: Salient Cues|BEHAVIORAL: Spaced Retrieval Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Glabellar Frown Lines No. 2
Status: COMPLETED
Conditions: Moderate to Severe Glabellar Frown Lines
Interventions: DRUG: IncobotulinumtoxinA (Xeomin) (20 Units)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Exercise for Middle-Aged Adults With Type 1 Diabetes and Other Absolute Insulin Deficiency Diabetes
Status: RECRUITING
Conditions: Type 1 Diabetes|Latent Autoimmune Diabetes in Adults|Pancreatitis
Interventions: BEHAVIORAL: Digital Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: 'Home Sweet Home' Programme-2
Status: RECRUITING
Conditions: Geriatric Hip Fracture
Interventions: BEHAVIORAL: Tele-rehabilitation caregiver empowerment enhanced post- discharge rehabilitation directive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: BioPearl™ Microspheres Loaded With Doxorubicin: Prospective, Single Arm, Multi-centre Post-market Follow-up Study.
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma
Interventions: DEVICE: Chemoembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Epacadostat, an IDO1 Inhibitor, in Combination With Pembrolizumab in Patients With Metastatic and/or Locally Advanced Sarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcoma
Interventions: DRUG: Epacadostat|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib for Hepatopulmonary Syndrome
Status: TERMINATED
Conditions: Hepatopulmonary Syndrome
Interventions: DRUG: Sorafenib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy With Monoclonal Antibody and Radioimmunotherapy for High-Risk B-Cell Non-Hodgkins Lymphoma
Status: COMPLETED
Conditions: Lymphoma, B-Cell
Interventions: DRUG: cyclophosphamide|DRUG: etoposide|DRUG: rituximab|DRUG: cytarabine|DRUG: doxorubicin|DRUG: tositumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacological Penile Rehabilitation in the Preservation of Erectile Function Following Bilateral Nerve-Sparing Radical Prostatectomy
Status: TERMINATED
Conditions: Penile Cancer|Erectile Dysfunction|Radical Prostatectomy
Interventions: DRUG: Placebo QHS and sildenafil and questionnaires|DRUG: Sildenafil and questionnaire|DRUG: Trimix combination (Papavarine 30mg/mL Phentholamine 1mg/mL Prostaglandin E1 10 mcg/mmL) and questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of ASC42 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ASC42|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Decision-making Impact of the Breast Cancer Index in Recommending Extended Adjuvant Endocrine Therapy for Patients With Early Stage ER-positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Early Stage Estrogen Receptor (ER) Positive Breast Cancer
Interventions: BEHAVIORAL: BCI Assay Results
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Slow Release Clotrimazole Varnish Treating Denture Stomatitis Comparing to Traditional Treatment of Troches
Status: COMPLETED
Conditions: Oral Candidiasis|Denture Stomatitis
Interventions: DRUG: Clotrimazole varnish|DRUG: Clotrimazole troches
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Three Interventions to Reduce Fear of Falling and Improve Functionality in the Elderly
Status: UNKNOWN
Conditions: Fear of Falling
Interventions: BEHAVIORAL: Cognitive behavioural therapy|OTHER: Tai chi|OTHER: Postural control exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Randomized Trial of ERCP Then Laparoscopic Cholecystectomy vs. Laparoscopic Cholecystectomy Plus Laparoscopic Common Bile Duct Exploration in Patients With Likely Choledocholithiasis
Status: COMPLETED
Conditions: Choleclithiasis|Common Bile Duct Stones
Interventions: PROCEDURE: ERCP|PROCEDURE: LapCBDE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT