pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: IV Iron Versus Standard Treatment for Iron Deficiency Anemia in the Emergency Department
Status: COMPLETED
Conditions: Iron Deficiency Anemia Treatment|Iron-deficiency|Iron Deficiency Anemia Due to Blood Loss|Iron Deficiency Anemia
Interventions: BIOLOGICAL: Packed red blood cells|DRUG: Intravenous drug
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Patch Graft Material Safety and Effectiveness in Covering Glaucoma Drainage Device Tube
Status: TERMINATED
Conditions: Primary Open Angle Glaucoma|Primary Angle Closure Glaucoma|Pseudoexfoliation Glaucoma|Pigmentary Glaucoma|Traumatic Glaucoma|Uveitic Glaucoma|Neovascular Glaucoma
Interventions: PROCEDURE: Molteno 3 glaucoma drainage shunt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Interventions for Successful Transition and Transfer of Adolescents With Inborn Errors of Metabolism to Adult Services
Status: RECRUITING
Conditions: Transition|Inborn Errors of Metabolism
Interventions: BEHAVIORAL: Behavioral
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Individual Neuromodulation for PDS
Status: RECRUITING
Conditions: Neuromodulation|Parkinsonian Syndromes|Transcranial Magnetic Stimulation|Transcranial Direct Current Stimulation
Interventions: DEVICE: Neuromodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lifitegrast 5% Ophthalmic Solution and Contact Lens Dryness
Status: COMPLETED
Conditions: Contact Lens|Contact Lens Discomfort|Contact Lens Dryness
Interventions: DRUG: Lifitegrast
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial of Diphenhydramine for Sleep in Children With Autism
Status: RECRUITING
Conditions: Autism|Autism Spectrum Disorder
Interventions: DRUG: Diphenhydramine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vaccine Treatment of Kidney Cancer
Status: TERMINATED
Conditions: Kidney Cancer
Interventions: DRUG: 117-126:Fibroblast growth factor 5 (FGF-5)|DRUG: Fibroblast growth factor 5 (FGF-5):172-176/217-220|OTHER: IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Ibuprofen Treatment of Patent Ductus Arteriosus (PDA) in Premature Infants (TRIOCAPI)
Status: COMPLETED
Conditions: Patent Ductus Arteriosus
Interventions: DRUG: Ibuprofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Circulating Tumour DNA (ctDNA) in Patients With Colorectal Cancer and the Relationship to Imaging Features of Extramural Venous Invasion
Status: RECRUITING
Conditions: Cancer|Rectal Cancer
Interventions: OTHER: Blood sample (mrEMVI positive patient)|OTHER: Blood sample (mrEMVI negative patient)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Ephedrine, Phenylephrine, Norepinephrine and Vasopressin on Contractility of Human Myometrium and Umbilical Vessels: An In-vitro Study
Status: RECRUITING
Conditions: Hypotension
Interventions: DRUG: Ephedrine|DRUG: Phenylephrine|DRUG: Norepinephrine|DRUG: Vasopressin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Research Study Comparing Different Tablets With the Study Medicine Semaglutide in Healthy Men
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide 3 mg|DRUG: Semaglutide 7 mg|DRUG: Semaglutide B 3 mg|DRUG: Semaglutide B 7 mg|DRUG: Semaglutide C 3 mg|DRUG: Semaglutide C 7 mg|DRUG: Semaglutide D 3 mg|DRUG: Semaglutide D 7 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Radiation Therapy With or Without Methotrexate in Treating Young Patients With Newly Diagnosed Gliomas
Status: UNKNOWN
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: cisplatin|DRUG: etoposide|DRUG: ifosfamide|DRUG: lomustine|DRUG: methotrexate|DRUG: prednisone|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CO2 Laser in the Treatment of the GSM - (Genitourinary Syndrome of Menopause) Genitourinary Syndrome of Menopause
Status: COMPLETED
Conditions: Menopause|Vaginal Atrophy|Urinary Incontinence
Interventions: RADIATION: CO2 fractional ablative laser
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety,PK/PD, Food Effect Study of Orally Administered HM71224 in Healthy Adult Male Volunteers
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: HM71224 single ascending dose|DRUG: HM71224 food effect|DRUG: HM71224 Multiple ascending dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Synbiotics in Infants With Cyanotic Congenital Heart Disease
Status: COMPLETED
Conditions: Congenital Heart Disease
Interventions: DIETARY_SUPPLEMENT: Bifidobacterium lactis plus inulin|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Wide Spectrum Investigation of Stroke Outcome Disparities on Multiple Levels (WISSDOM)
Status: COMPLETED
Conditions: Stroke Ischemic|Minority Health
Interventions: BEHAVIORAL: Community-based Intervention under Nurse Guidance after Stroke
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effectivity of End-tidal CO2 and Oxygen Reserve Index (ORI) Monitoring in Sedation
Status: COMPLETED
Conditions: Hypoxemia|Procedural Sedation|Hypercapnia|Apnea
Interventions: DEVICE: Oxygen Reserve Index, Masimo Corporation, USA.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Acceptability of Two Lubricant Eye Drops
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: Lubricant Eye Drops (Optive™)|DRUG: Lubricating Eye Drops (blink® Tears)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Food Modification to Alter Glycaemia and Insulinaemia
Status: COMPLETED
Conditions: Diabetes
Interventions: OTHER: Glucose Reference 1|OTHER: Glucose Reference 2|OTHER: Glucose Reference 3|OTHER: Wheat Yellow Noodle|OTHER: Beta-glucan yellow Noodle|OTHER: Rice Roll|OTHER: Rice Roll with resistant starch|OTHER: Sucrose Jelly|OTHER: Isomaltulose Jelly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Yoga and Cardiovascular Exercise on Smoking Motivation
Status: COMPLETED
Conditions: Tobacco Dependence
Interventions: BEHAVIORAL: Hatha Yoga (HY)|BEHAVIORAL: Cardiovascular Exercise (CE)|BEHAVIORAL: Smoking Cessation Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Recombinant Human Endostatin in Combination With mFOLFOX6 in Patients With Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Neoplasm
Interventions: DRUG: recombinant human endostatin (Endostat)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metastasis-directed Therapy for Oligorecurrent Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer|Prostate Cancer Recurrent|Prostate Cancer Metastatic|Metastatic Cancer|Oligometastatic Disease|Oligometastasis|Hormone Sensitive Prostate Cancer
Interventions: OTHER: Radiotherapy (SBRT) and/or surgery (metastasectomy)|DRUG: Androgen deprivation therapy|DRUG: Androgen receptor targeted therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zambia SiVET MMR Tdap-IPV
Status: COMPLETED
Conditions: High Risk for HIV
Interventions: BIOLOGICAL: Tdap - IPV Vaccine|BIOLOGICAL: MMR Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Optimizing Social and Communication Outcomes for Toddlers With Autism
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Caregiver-Mediated Intervention|BEHAVIORAL: Caregiver-Education Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Robotic Endomicroscopy to Better Define Resection Strategies Applied to Hepatic Surgery
Status: UNKNOWN
Conditions: Hepatocarcinoma|Hepatic Metastasis|Hepatic Tumor
Interventions: DEVICE: Confocal Laser Endomicroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy Study Evaluating TRx0237 in Subjects With Behavioral Variant Frontotemporal Dementia (bvFTD)
Status: COMPLETED
Conditions: Behavioral Variant Frontotemporal Dementia (bvFTD)
Interventions: DRUG: TRx0237|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of PRCL-02 in Moderate to Severe Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis Vulgaris|Plaque Psoriasis
Interventions: DRUG: PRCL-02|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of ASN-002 in Adult Patients With Low-risk Nodular Basal Cell Carcinoma
Status: COMPLETED
Conditions: Basal Cell Nevus Syndrome|Skin Neoplasm|Nodular Basal Cell Carcinoma of Skin
Interventions: BIOLOGICAL: ASN-002|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Anti-PD-1 Antibody SHR-1210 Plus Nimotuzumab in the Treatment of Advanced Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Nimotuzumab + SHR-1210
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Engaging College Students in Developing and Testing a Video-based Intervention for HPV Vaccination Promotion
Status: NOT_YET_RECRUITING
Conditions: N/A - Healthy Subjects
Interventions: OTHER: short videos related to HPV vaccines|OTHER: CDC HPV Fact Sheet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: One Step at a Time: An Intervention to Reduce Sedentary Behavior Among Working Adults
Status: COMPLETED
Conditions: Sedentary Behavior|Exercise|Middle Age|Adult
Interventions: BEHAVIORAL: Decrease Sedentary Time + Increase MVPA group|BEHAVIORAL: Increase MVPA group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Robot-assisted Procedure Versus Open Simultaneous Resection of Colorectal Cancer With Liver Metastases
Status: UNKNOWN
Conditions: Colorectal Liver Metastasis
Interventions: PROCEDURE: RSRCLM|PROCEDURE: Open
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Effects of Epoetin Hospira and Epogen/Epoetin Alfa (Amgen) When Administered IV in Patients With Chronic Renal Failure Requiring Hemodialysis and Receiving Epoetin Maintenance Treatment
Status: COMPLETED
Conditions: Chronic Renal Failure
Interventions: DRUG: Epoetin Hospira|DRUG: Epogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tarceva (Erlotinib) in Elderly Patients With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: erlotinib [Tarceva]|DRUG: vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Systems Biological Assessment of the Durability of Vaccine Responses
Status: RECRUITING
Conditions: Vaccine Response
Interventions: BIOLOGICAL: Live Attenuated Yellow Fever 17D Vaccine|BIOLOGICAL: Quadrivalent seasonal influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Transcranial Direct Current Stimulation for the Treatment of Bipolar Depression
Status: COMPLETED
Conditions: Depression, Bipolar
Interventions: DEVICE: Sham stimulation|DEVICE: Active stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Piamprilizumab (AK105) Combined With Radiotherapy for Neoadjuvant Treatment of Soft Tissue Sarcoma
Status: RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: Piamprimab (AK105)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reminerlization Potential of GSE Gel versusCPP-ACP in Carious White Spot Lesions in Post Orthodontic Patients
Status: UNKNOWN
Conditions: Dental Caries
Interventions: OTHER: Grape seeds extract|OTHER: Casein-phosphopeptide/amorphous-calcium phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pupil Centroid Shift Compensation in Photorefractive Keratectomy Candidates
Status: UNKNOWN
Conditions: Pupil Centroid Shift
Interventions: PROCEDURE: The option for compensation of Pupil centroid shift was ON|PROCEDURE: The option for compensation of Pupil centroid shift was OFF|DRUG: installation of Tetracaine 1%|PROCEDURE: Photorefractive keratectomy (PRK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Endovenous Laser Therapy (EVLT) for Sapheno-Popliteal Incompetence and Short Saphenous Vein (SSV) Reflux: A RCT
Status: ACTIVE_NOT_RECRUITING
Conditions: Venous Insufficiency|Varicose Veins
Interventions: PROCEDURE: Surgery|PROCEDURE: EVLT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Methodology to Rapidly Evaluate Drugs for Bactericidal Activity, Tolerance, and Pharmacokinetics in the Treatment of Pulmonary Tuberculosis Using Isoniazid and Levofloxacin
Status: COMPLETED
Conditions: HIV Infections|Tuberculosis
Interventions: DRUG: Isoniazid|DRUG: Pyridoxine hydrochloride|DRUG: Levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: XVIVO Heart Perfusion System (XHPS) With Supplemented XVIVO Heart Solution (SXHS)
Status: RECRUITING
Conditions: Heart Failure|Transplant; Failure, Heart
Interventions: DEVICE: Non-Ischemic Heart Preservation (NIHP) using the XVIVO Heart Preservation System (XHPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antidepressant Treatment of Melancholia in Late Life
Status: COMPLETED
Conditions: Depression|Melancholia
Interventions: DRUG: Sertraline|DRUG: Nortriptyline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Light Therapy and Occupational Therapy Fatigue Management-Based Intervention for Patients With Genitourinary Cancers
Status: RECRUITING
Conditions: Bladder Carcinoma|Genitourinary System Neoplasm|Kidney Carcinoma|Prostate Carcinoma
Interventions: OTHER: Best Practice|DEVICE: Bright White Light Therapy|BEHAVIORAL: Occupational Therapy|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Tolerability of SYNB1020-CP-001
Status: COMPLETED
Conditions: Healthy Volunteer|Urea Cycle Disorder
Interventions: DRUG: Placebo|DRUG: SYNB1020
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Depsipeptide/Flavopiridol Infusion for Cancers of the Lungs, Esophagus, Pleura, Thymus or Mediastinum
Status: TERMINATED
Conditions: Carcinoma, Small Cell|Carcinoma, Non-Small-Cell Lung|Esophageal Neoplasms|Mesothelioma
Interventions: DRUG: Depsipeptide|DRUG: Flavopiridol (alvocidib)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The PK Characteristics of the Co-administration of Metformin SR and Rosuvastatin and JLP-1310 in Healthy Male Volunteers.
Status: COMPLETED
Conditions: Diabetes|Hyperlipidemias
Interventions: DRUG: "Metformin" and "Rosuvastatin" seperately|DRUG: JLP-1310
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Preconditioned Adipose-Derived Stem Cells in Fat Grafting
Status: RECRUITING
Conditions: Romberg Disease|Craniofacial Microsomia|Burn Scar|Post-Traumatic Scar (Disorder)
Interventions: BIOLOGICAL: Cultured ASCs enrichment fat grafting|BIOLOGICAL: Curcumin-preconditioned ASCs enrichment fat grafting|OTHER: Conventional fat grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Atezolizumab + Bevacizumab in Patients With Advanced Non-Clear Cell Renal Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Non-Clear Cell Kidney Cancer
Interventions: DRUG: Bevacizumab|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lidocaine For Treatment of Post-operative Pain From Donor Sites Following Burn Injury.
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Lidocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pharmacokinetic Drug-drug Interactions Between Hormonal Contraceptives and Doravirine-containing ART Among Women Living With HIV in South Africa
Status: COMPLETED
Conditions: HIV Infections|Contraception|Drug-drug Interaction
Interventions: DRUG: Etonogestrel (ETG) implant|DRUG: Intramuscular depo-medroxyprogesterone acetate (IM DMPA)|DRUG: Sub-cutaneous medroxyprogesterone acetate (SC MPA)|DEVICE: Non-hormonal intrauterine device (IUD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab Treatment For Type 1 ROP
Status: RECRUITING
Conditions: Retinopathy of Prematurity
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Intranasal GSK2245035 in Adults With Allergic Asthma
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: GSK2245035|DRUG: Placebo|DRUG: FP-DPI|DRUG: Albuterol/Salbutamol|OTHER: eDairy|OTHER: ACQ-6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY900014 in Participants With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: LY900014|DRUG: Insulin Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influence of Food on the Bioavailability of Two Doses of Telmisartan/HCTZ Fixed-dose Combination in Japanese Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Telmisartan low|DRUG: Telmisartan high|DRUG: Hydrochlorothiazide (HCTZ)|OTHER: Japanese meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mother-Baby Study - Observational
Status: RECRUITING
Conditions: Obesity, Childhood|Obesity
Interventions: BEHAVIORAL: Bonding-Evoked Oxytocin|BEHAVIORAL: Distress Relieving Effects of Sucrose|BEHAVIORAL: Hedonic Response to Sucrose|BEHAVIORAL: Typical versus Challenging Feeding-Social|BEHAVIORAL: Caloric Compensation-Social|BEHAVIORAL: Ability to Delay Gratification for Food in Infants-Social Task (ATDG-FIT-Social)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prospective Thinking in Hormone-Responsive Breast Cancer
Status: COMPLETED
Conditions: Hormone Receptor Positive Malignant Neoplasm of Breast
Interventions: BEHAVIORAL: Episodic future thinking|BEHAVIORAL: Episodic recent thinking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Stem Cell Transplantation (SCT) for Genetic Diseases
Status: COMPLETED
Conditions: Thrombocytopenia|Metachromatic Leukodystrophy|Fanconi's Anemia|Thalassemia Major|Pure Red-Cell Aplasia|Inborn Errors of Metabolism
Interventions: PROCEDURE: Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Randomized Clinical Trial to Define the Best Strategy for the Management of Heart Failure and Chronic Kidney Disease.
Status: NOT_YET_RECRUITING
Conditions: Heart Failure|Chronic Kidney Diseases
Interventions: DRUG: Sodium Zirconium Cyclosilicate|DRUG: Standard of care treatment (RAASi therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RepurpoSing Old Drugs TO SuppRess a Modern Threat: COVID-19 STORM
Status: WITHDRAWN
Conditions: Cytokine Storm|SARS-CoV-2
Interventions: DRUG: Doxycycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Post-Operative Cesarean Section Cosmesis
Status: NOT_YET_RECRUITING
Conditions: Cesarean Delivery
Interventions: PROCEDURE: absorbable subcuticular polyglycolic acid staples (INSORB)|PROCEDURE: subcuticular, polyglecaprone suture (Monocryl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Low Level Laser Therapy Impact on Cognitive Function and Quality of Life in Alzheimer Anemic Elderly Patients
Status: COMPLETED
Conditions: Alzheimer Disease|Cognitive Impairment, Mild
Interventions: DEVICE: low level laser therapy ( laser acupuncture combined with nasal laser irradiation)|OTHER: aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Partnership in Implementation Science for Geriatric Mental Health (PRISM)
Status: UNKNOWN
Conditions: Behavioral and Psychological Symptoms of Dementia (BPSD)
Interventions: BEHAVIORAL: Physical Exercise Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sorafenib in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Refractory Multiple Myeloma
Interventions: DRUG: sorafenib tosylate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safe Time for Apnea After Preoxygenation
Status: COMPLETED
Conditions: Anesthesia, General
Interventions: DRUG: 100% Oxygen|DRUG: 30% Oxygen|DRUG: 21% Oxygen|DRUG: 40% Oxygen|DRUG: 60% Oxygen|DRUG: 80% Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: CES1 Crossover Trial of Clopidogrel and Ticagrelor
Status: COMPLETED
Conditions: Myocardial Infarction|Thrombosis|Platelet Dysfunction
Interventions: DRUG: Clopidogrel|DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial to Assess Continuous Glucose Monitoring in Asian Americans With Type 2 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: Continuous Glucose Monitor|BEHAVIORAL: Finger stick glucose monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Do Oral Contraceptives Protect Against ACL Injuries in Female Athletes
Status: RECRUITING
Conditions: Ligament Injury
Interventions: DRUG: Oral Contraceptive Pill, norethindrn a-e estradiol-iron
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Of White Blood Cells In The Cerebrospinal Fluid And Blood Of Patients With Relapsing Forms Of Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: firategrast
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise Rehabilitation Via a Mobile Application for Individuals With Breast Cancer Undergoing Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Upper Extremity Dysfunction
Interventions: BEHAVIORAL: general exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Investigate a New Treatment in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: IPT803|GENETIC: Optional pharmacogenetic assessment|OTHER: Questionnaires|OTHER: Optional Blood-Oxygen-level Dependent functionalMRI|OTHER: Motor Assessments before taking regular PD treatment|OTHER: Motor Assessments on regular PD treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: (Cost)-Effectiveness of Optical Coherence Tomography (OCT) in Basal Cell Carcinoma (BCC)
Status: UNKNOWN
Conditions: Basal Cell Carcinoma|Optical Coherence Tomography
Interventions: DEVICE: Optical Coherence Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Rapid Antigen Testing of Students for COVID-19 in Reducing Absences From Schools in Bangladesh
Status: COMPLETED
Conditions: School Absenteeism
Interventions: DIAGNOSTIC_TEST: Rapid Antigen Testing (RAT) for COVID-19
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Fluorouracil, Leucovorin, and Oxaliplatin With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II or Stage III Colon Cancer
Status: COMPLETED
Conditions: Colon Adenocarcinoma|Stage IIA Colon Cancer AJCC v7|Stage IIB Colon Cancer AJCC v7|Stage IIC Colon Cancer AJCC v7|Stage IIIA Colon Cancer AJCC v7|Stage IIIB Colon Cancer AJCC v7|Stage IIIC Colon Cancer AJCC v7
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Fluorouracil|DRUG: Leucovorin Calcium|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tamsulosin/Solifenacin Combination Therapy in Patients With Voiding Symptoms and Moderate to Severe Storage Symptoms Due to Benign Prostate Hyperplasia
Status: UNKNOWN
Conditions: Benign Prostate Hyperplasia
Interventions: DRUG: Tamsulosin|DRUG: Solifenacin|DRUG: Solifenacin placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Tolerability of CC-91633 (BMS-986397) in Participants With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher-Risk Myelodysplastic Syndromes
Status: RECRUITING
Conditions: Leukemia, Myeloid, Acute|Myelodysplastic Syndromes
Interventions: DRUG: CC-91633
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Doxycycline 100mg and Doxycycline 20mg in Treatment of Mild and Moderate Acne
Status: UNKNOWN
Conditions: Acne|Inflammation
Interventions: DRUG: Doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Eslicarbazepine Acetate (BIA 2-093) in Acute Manic Episodes Associated With Bipolar I Disorder
Status: COMPLETED
Conditions: Bipolar I Disorder
Interventions: DRUG: Eslicarbazepine Acetate|DRUG: Eslicarbazepine Acetate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Calcium Silicate Versus Calcium Hydroxide in Two-step Indirect Pulp Treatment
Status: COMPLETED
Conditions: Deep Caries
Interventions: OTHER: Calcium hydroxide|OTHER: Calcium silicate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Sport Specific Adaptations of the Shoulder in Adolescent Elite Handball Players and the Influence of the Preventive Use of Tape on These Outcome Measurements.
Status: COMPLETED
Conditions: Risk Factors for Shoulder Injuries
Interventions: OTHER: Dynamic ultrasound|OTHER: FASTRAK|OTHER: Assessment of shoulder posture by measuring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Donor Lymphocytes to Prevent Graft-Versus-Host Disease in Patients With Chronic Myeloid Leukemia
Status: WITHDRAWN
Conditions: Graft Versus Host Disease|Leukemia
Interventions: BIOLOGICAL: therapeutic allogeneic lymphocytes|DRUG: cytarabine|DRUG: fludarabine phosphate|DRUG: idarubicin|DRUG: methotrexate|DRUG: tacrolimus|PROCEDURE: in vitro-treated peripheral blood stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diet in Elderly With Type 2 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Sarcopenia|Sarcopenic Obesity|Diabetes Mellitus|Diabetes Mellitus, Type 2|Diabetes Complications
Interventions: DIETARY_SUPPLEMENT: mediterranean diet with adequate protein intake
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Accuracy of the MADx Multi Array Xplorer (MAX 45k) Automated Laboratory System and the MADx Allergy Explorer Version 2 (ALEX²) - IgE Multiplex Test for the Diagnosis of Pre-defined Groups of Specific High-priority Allergens
Status: COMPLETED
Conditions: Birch Pollen Allergy|Grass Pollen Allergy|House Dust Mite Allergy|Cat Allergy|Bee Venom Allergy|Vespid Venom Allergy
Interventions: DIAGNOSTIC_TEST: ALEX² test using the MAX 45k automated laboratory system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Melatonin on Nocturnal Enuresis
Status: UNKNOWN
Conditions: Nocturnal Enuresis
Interventions: DRUG: Melatonin|DRUG: Lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Recombinant Interleukin-12 in Treating Patients With Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Malignant Solid Neoplasm|Unresectable Malignant Solid Neoplasm
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|BIOLOGICAL: Edodekin alfa|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Pembrolizumab|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DSP-3025 Study of Healthy Male Volunteers and Seasonal Allergic Rhinitis Male Patients Out of Season
Status: COMPLETED
Conditions: Allergic Rhinitis|Healthy Volunteer
Interventions: DRUG: DSP-3025|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose:
Clinical trial: Efficacy and Safety of Fingolimod in Patients With Relapsing-remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing-remitting Multiple Sclerosis
Interventions: DRUG: Fingolimod 1.25 mg|DRUG: Fingolimod 0.5 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Ann Arbor Stage III Non-Hodgkin Lymphoma|Ann Arbor Stage IV Non-Hodgkin Lymphoma|Malignant Glioma|Recurrent Ependymoma|Recurrent Ewing Sarcoma|Recurrent Glioma|Recurrent Hepatoblastoma|Recurrent Langerhans Cell Histiocytosis|Recurrent Malignant Germ Cell Tumor|Recurrent Malignant Solid Neoplasm|Recurrent Medulloblastoma|Recurrent Neuroblastoma|Recurrent Non-Hodgkin Lymphoma|Recurrent Osteosarcoma|Recurrent Peripheral Primitive Neuroectodermal Tumor|Recurrent Primary Central Nervous System Neoplasm|Recurrent Rhabdomyosarcoma|Recurrent Soft Tissue Sarcoma|Refractory Langerhans Cell Histiocytosis|Refractory Malignant Germ Cell Tumor|Refractory Malignant Solid Neoplasm|Refractory Neuroblastoma|Refractory Non-Hodgkin Lymphoma|Refractory Primary Central Nervous System Neoplasm|Rhabdoid Tumor|Stage III Osteosarcoma AJCC v7|Stage III Soft Tissue Sarcoma AJCC v7|Stage IV Osteosarcoma AJCC v7|Stage IV Soft Tissue Sarcoma AJCC v7|Stage IVA Osteosarcoma AJCC v7|Stage IVB Osteosarcoma AJCC v7|Wilms Tumor
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: FDG-Positron Emission Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Samotolisib|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Study of Two Supraglottic Airway Devices Used for Patients Under General Anesthesia
Status: COMPLETED
Conditions: Anesthesia Airway Management
Interventions: DEVICE: I-Gel supraglottic airway device|DEVICE: LMA Supreme supraglottic airway device|DEVICE: Standard endotracheal tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Become Your Own SLEEPexpert: a Behavioral Treatment Program for Insomnia in Patients With Psychiatric Disorders
Status: RECRUITING
Conditions: Insomnia Disorder
Interventions: DEVICE: SLEEPexpert|OTHER: TAU plus sleep monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Trastuzumab in Treating Women With Stage I, Stage II, or Stage III HER2-Positive Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: aromatase inhibition therapy|DRUG: cyclophosphamide|DRUG: docetaxel|DRUG: doxorubicin hydrochloride|DRUG: epirubicin hydrochloride|DRUG: fluorouracil|DRUG: paclitaxel|DRUG: releasing hormone agonist therapy|DRUG: tamoxifen citrate|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Low Dosage of rt-PA in the Treatment of Pulmonary Thromboembolism in China
Status: COMPLETED
Conditions: Pulmonary Embolism|Thromboembolism
Interventions: DRUG: rt-PA|DRUG: rt-PA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of HC-5404-FU to Establish the Maximum Tolerated Dose (MTD)
Status: COMPLETED
Conditions: Renal Cell Carcinoma|Gastric Cancer|Metastatic Breast Cancer|Small-cell Lung Cancer|Other Solid Tumors
Interventions: DRUG: HC-5404-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Use of Atosiban for Ultrasound-indicated Cerclage to Reduce Spontaneous Preterm Birth(sPTB)
Status: COMPLETED
Conditions: Cervical Cerclage|Premature Birth
Interventions: DRUG: Atosiban|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Safety, Tolerability and Pharmacokinetics of Multiple Subcutaneous Injections of ABBV-257 in Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: ABBV-257|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Liberia National Community Health Assistant (NCHA) Program and Under-five Mortality
Status: UNKNOWN
Conditions: Malaria|Diarrhea|Acute Respiratory Infection|Malnutrition, Child
Interventions: BEHAVIORAL: Liberia National Community Health Assistant Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Fospropofol Disodium Versus Propofol for Sedation in Mechanically Ventilated ICU Patients
Status: COMPLETED
Conditions: Critical Illness
Interventions: DRUG: Fospropofol disodium for injection|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Topical Betamethasone and Clobetasol in Orabase in Oral Lichen Planus
Status: UNKNOWN
Conditions: Oral Lichen Planus
Interventions: DRUG: Betamethasone Dipropionate|DRUG: Clobetasol Propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ease of Use and Microbial Contamination of Tobramycin Inhalation Powder (TIP) Versus Nebulised Tobramycin Inhalation Solution (TIS) and Nebulised Colistimethate (COLI)
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Tobramycin Inhalation Powder|DRUG: Tobramycin inhalation solution|DRUG: Colistimethate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Patients With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Foster® NEXThaler® 100/6 µg/unit dose|DRUG: Seretide® Accuhaler® 250/50 µg/actuation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of IBI112 in Chinese Patients With Psoriasis Who Were Previously Treated With Biologics
Status: ACTIVE_NOT_RECRUITING
Conditions: Psoriasis
Interventions: DRUG: regular treatment|DRUG: Intensive treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Levonorgestrel-Intrauterine System (LNG-IUS) Insertion in the Postpartum Period
Status: COMPLETED
Conditions: Contraception
Interventions: DEVICE: Levonorgestrel Intrauterine System (LNG-IUS: Mirena, Bayer)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Human Factors Simulation Study Protocol for the Assessment of Usability of Innovative Personal Protective Equipment
Status: NOT_YET_RECRUITING
Conditions: Personal Protective Equipment
Interventions: DEVICE: Innovative PPE|DEVICE: Traditional PPE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Comparative Effectiveness of Social Physical Play and Traditional Exercise Programming
Status: COMPLETED
Conditions: Group Fitness (Traditional)|Group Fitness (Game Play-based)
Interventions: BEHAVIORAL: Group Fitness|BEHAVIORAL: PlayFit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Relative Bioavailability of BI 1015550 Following Oral Administration Under Fed and Fasted Conditions in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1015550|DRUG: BI 1015550
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Durvalumab With or Without Tremelimumab in Treating Participants With Stage II-IVA Oropharyngeal Squamous Cell Cancer
Status: COMPLETED
Conditions: Stage II Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7|Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7
Interventions: BIOLOGICAL: Durvalumab|BIOLOGICAL: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cataract DME - Peri vs. Intraop
Status: WITHDRAWN
Conditions: Diabetic Macular Edema|Cataract
Interventions: DRUG: Aflibercept injected Pre- and Post-operatively|DRUG: Aflibercept injected intraoperatively
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dapagliflozin Evaluation in Patients With Inadequately Controlled Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Dapagliflozin|OTHER: Placebo for dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prognosis of Patients With Compete Left Bundle Branch Block
Status: RECRUITING
Conditions: Bundle-Branch Block, Left|Cardiac Failure|ICD/Pacemaker Implantation|Cardiovascular Magnetic Resonance Imaging
Interventions: DIAGNOSTIC_TEST: Cardiac Magnetic Resonance Imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Gel and Solution of Chlorhexidine in Disinfection Root Canals of Primary Anterior Teeth.
Status: COMPLETED
Conditions: Dental Caries|Infection, Bacterial|Tooth, Deciduous
Interventions: OTHER: Chlorhexidine solution|OTHER: Activated chlorhexidine solution|OTHER: Chlorhexidine gel|OTHER: Activated chlorhexidine gel|OTHER: Sodium hypochlorite solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repeated Transcranial Magnetic Stimulation Relieve Chronic Visceral Pain in IBS
Status: RECRUITING
Conditions: Irritable Bowel Syndrome|Repetitive Transcranial Magnetic Stimulation|Chronic Visceral Pain|Functional Magnetic Resonance Imaging
Interventions: DEVICE: repeated transcranial magnetic stimulation treatment group|DRUG: Western medicine group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Donor Cytomegalovirus-Specific Cytotoxic T-Lymphocytes in Treating Patients With a Persistent Cytomegalovirus Infection
Status: ACTIVE_NOT_RECRUITING
Conditions: Cytomegaloviral Infection|Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: BIOLOGICAL: Allogeneic Cytomegalovirus-Specific Cytotoxic T lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT