pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Natural History Study of Children With LAMA2-related Dystrophies
Status: NOT_YET_RECRUITING
Conditions: Merosin Deficient Congenital Muscular Dystrophy
Interventions: OTHER: Motor evaluations|OTHER: Cognitive assessment|OTHER: Pulmonary function test|OTHER: Cardiac evaluation|OTHER: Quality of life|OTHER: Spine X Ray|OTHER: Muscular MRI|OTHER: Biomarkers collection and analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Anti-HIV Immunoglobulin (HIVIG) in Prevention of Maternal-Fetal HIV Transmission (Pediatric ACTG Protocol 185)
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome|Disease Transmission, Vertical|HIV Infections
Interventions: DRUG: immunoglobulins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Weight Loss Induced by Bariatric Surgery vs Conventional Treatment
Status: UNKNOWN
Conditions: Obesity
Interventions: BEHAVIORAL: Lifestyle Changes|OTHER: Adjustment of oral antidiabetics/insulin therapy|PROCEDURE: Laparoscopic sleeve gastrectomy|PROCEDURE: Laparoscopic Roux-en-Y gastric bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Dasatinib in Patients With Chronic Phase Chronic Myeloid Leukemia and a Suboptimal Response to Imatinib
Status: TERMINATED
Conditions: Leukemia, Myeloid, Chronic
Interventions: DRUG: Imatinib|DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IVF Outcome Following Progestogen Ovarian Stimulation
Status: COMPLETED
Conditions: IVF|Oocyte Maturation Defect 1|Clinical Pregnancy Rate|Ovarian Hyperstimulation
Interventions: DRUG: Dydrogesterone Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: LifeSkills Video Training in Patients About to Receive an Automatic Implantable Cardioverter-Defibrillator (AICD)
Status: COMPLETED
Conditions: Focus Whether After Implant Pre-AICD Video Was Helpful
Interventions: BEHAVIORAL: Video/workbook for patients about to receive an AICD|BEHAVIORAL: LiveSkills Video/Workbook for patients about to receive an AICD
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Osteopathic Manual Therapy on Infant Colic
Status: RECRUITING
Conditions: Colic, Infantile
Interventions: OTHER: Intervention of the experimental group (EG)|OTHER: Control Group (CG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Venetoclax, Dasatinib, Prednisone, Rituximab and Blinatumomab for the Treatment of Newly Diagnosed or Relapsed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia or Mixed Phenotype Acute Leukemia
Status: RECRUITING
Conditions: B Acute Lymphoblastic Leukemia|B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|Mixed Phenotype Acute Leukemia|Recurrent B Acute Lymphoblastic Leukemia|Recurrent Mixed Phenotype Acute Leukemia
Interventions: DRUG: Dasatinib|DRUG: Methotrexate|DRUG: Prednisone|BIOLOGICAL: Rituximab|DRUG: Venetoclax|BIOLOGICAL: Blinatumomab|PROCEDURE: Bone Marrow Aspiration and Biopsy|PROCEDURE: Lumbar Puncture|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apixaban Versus Warfarin in Patients With Left Ventricular Thrombus
Status: COMPLETED
Conditions: Left Ventricular Thrombosis
Interventions: DRUG: Apixaban 5 MG Oral Tablet [ELIQUIS]|DRUG: Warfarin Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Subjects Switched to Lurasidone for the Treatment of Schizophrenia or Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Lurasidone HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Trial of Acute N-Acetylcysteine Effects on Working Memory and Other Cognitive Functions in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DIETARY_SUPPLEMENT: N-Acetylcysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Different Macronutrient Compositions and Meal Distributions of the Food
Status: UNKNOWN
Conditions: Metabolic Rate|Plasma Glucose|Serum Insulin|Serum Triglycerides|Sense of Satiety
Interventions: OTHER: two test meals with two different macronutrient compositions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy, Safety And Tolerability Study In Subjects With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: PF-06412562|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: CVM-1118 in Combination With Nivolumab for Unresectable Advanced Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Advanced Cancer
Interventions: DRUG: Nivolumab Injection [Opdivo]|DRUG: CVM-1118
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ruxolitinib (INCB018424) in Participants With Primary Myelofibrosis (PMF), Post Essential Thrombocythemia-myelofibrosis and Post Polycythemia Vera-myelofibrosis (PPV-MF)
Status: COMPLETED
Conditions: MPN (Myeloproliferative Neoplasms)
Interventions: DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Boronophenylalanine (BPA)-Based Boron Neutron Capture Therapy (BNCT) in the Treatment Head and Neck Tumors
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: RADIATION: boronophenylalanine-based BNCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Neoadjuvant Gemcitabine and Cisplatin in Locoregionally Advanced Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Drug: Gemcitabine and cisplatin|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anabolic Therapy in Postmenopausal Osteoporosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: Romosozumab|DRUG: Denosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Adult Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetics of Multiple Doses of ABT-333
Status: COMPLETED
Conditions: HCV Infection
Interventions: DRUG: ABT-333|DRUG: ketoconazole|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Study of GDC-0980 Versus Everolimus in Participants With Metastatic Renal Cell Carcinoma Who Have Progressed on or Following Vascular Endothelial Growth Factor- (VEGF) Targeted Therapy
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Everolimus|DRUG: GDC-0980
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alvocidib, Oxaliplatin, Fluorouracil, and Leucovorin Calcium in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: alvocidib|DRUG: fluorouracil|DRUG: oxaliplatin|DRUG: leucovorin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assess the Effect of Daily Treatment of Vardenafil 20mg or Sildenafil 100mg and Placebo on Sperm Function
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Levitra (Vardenafil, BAY38-9456)|DRUG: Sildenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effectiveness of Ezetimibe/Atorvastatin 10 mg/20 mg Combination Tablet Compared to Marketed Ezetimibe 10 mg and Atorvastatin 20 mg Tablets in Participants With High Cholesterol (MK-0653C-185 AM1)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Atorvastatin|DRUG: Ezetimibe|DRUG: Ezetimibe/atorvastatin|DRUG: Placebo to atorvastatin|DRUG: Placebo to ezetimibe|DRUG: Placebo to ezetimibe/atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-response Study of Spinally Administered Ropivacaine for Caesarean Section in Tall Parturients
Status: ENROLLING_BY_INVITATION
Conditions: Regional Anaesthesia|Cesarean Section
Interventions: OTHER: Ropivacaine|OTHER: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allo BMT in Advanced Leukemia or High Grade Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin|Leukemia|Blood and Marrow Transplant (BMT)|Lymphomas: Non-Hodgkin
Interventions: PROCEDURE: ablative allogeneic hematopoietic cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation Of Zirconia Crowns Restoring Endodontically Treated Posterior Teeth With Two Finish Line Designs And Occlusal Reduction Schemes
Status: COMPLETED
Conditions: Gingival Inflammation
Interventions: OTHER: Abutment with flat occlusal reduction with feather edge finish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatments and Combinations in Patients With Urothelial Carcinoma (MORPHEUS-UC)
Status: RECRUITING
Conditions: Urothelial Carcinoma|Bladder Cancer
Interventions: DRUG: Atezolizumab|DRUG: Enfortumab Vedotin|DRUG: Niraparib|DRUG: Magrolimab (Hu5F9-G4)|DRUG: Tiragolumab|DRUG: Sacituzumab Govitecan|DRUG: Tocilizumab|DRUG: Cisplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Zonisamide on Cocaine Reinforcement, Craving, and Relapse
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: Zonisamide|DRUG: Placebo|DRUG: Cocaine Hydrochloride|BEHAVIORAL: Neurocognitive and Performance Battery|BEHAVIORAL: Smoking Assessments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Deep Brain Stimulation of the Superolateral Branch of the Medial Forebrain Bundle (slMFB) for the Treatment of Refractory Major Depression
Status: COMPLETED
Conditions: Major Depression
Interventions: DEVICE: Deep Brain Stimulation with Activa PC Multi-program Neurostimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Intra-patient Variability of the Quantitative Parameters of Tumor Perfusion Evaluated With Ultrasound Contrast
Status: COMPLETED
Conditions: GIST Metastatic Cancer|Breast Metastatic Cancer|Kidney Metastatic Cancer|Colon Metastatic Cancer|Rectal Metastatic Cancer
Interventions: DEVICE: CEUS (Contrast-enhanced ultrasound)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Treatment of Tumors of the Choroid Plexus Epithelium
Status: TERMINATED
Conditions: Choroid Plexus Tumors
Interventions: DRUG: Carboplatin|DRUG: Cyclophosphamide|DRUG: Etoposide|DRUG: Vincristine|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the FreedomFlow™ Orbital Atherectomy System to Treat Peripheral Artery Disease
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: Orbital Circumferential Atherectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SKIPping With PAX: An Integrated Gross Motor and Social-Emotional Skill Intervention
Status: ACTIVE_NOT_RECRUITING
Conditions: Gross Motor Development Delay|Social Skills|Social Behavior|Sedentary Behavior
Interventions: BEHAVIORAL: Integrated Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: L-Threonic Acid Magnesium Salt (L-TAMS) in ADHD
Status: COMPLETED
Conditions: Attention Deficit/Hyperactivity Disorder|ADHD
Interventions: DRUG: L-Threonic Acid Magnesium Salt (L-TAMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Multiple Mega-dose of Vitamin D3 Supplementation on Ameliorating Moderate to Severe Chronic Pain in Hemodialysis Patients
Status: RECRUITING
Conditions: Hemodialysis|Chronic Pain|Hyperparathyroidism
Interventions: OTHER: Vitamin D|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Palm Tocotrienols in Chronic Hemodialysis (Malaysia) (PATCH)
Status: UNKNOWN
Conditions: Chronic Kidney Failure
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: TRF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy and Real-time Self-management Intervention for SCD Via Mobile Applications
Status: COMPLETED
Conditions: Sickle Cell Disease|Depression|Anxiety
Interventions: BEHAVIORAL: Computerized cognitive behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D3 For CGD Patients With BCGosis/Itis
Status: COMPLETED
Conditions: Vitamin D3|Chronic-granulomatous Disease|BCG
Interventions: DRUG: Vitamin D3|DRUG: Traditional treatment of CGD and TB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Repaglinide and Metformin Administered Alone or in Combination in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: repaglinide|DRUG: metformin|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in the Treatment of Osteoarthritis Knee Pain
Status: COMPLETED
Conditions: Osteoarthritis Knee Pain
Interventions: DRUG: Placebo|DRUG: LY545694 49 mg|DRUG: LY545694 105 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Children's Cooperation During Dental Injection
Status: WITHDRAWN
Conditions: Child Behavior|Acute Pain
Interventions: BEHAVIORAL: behavioral priming|BEHAVIORAL: endowment effect|BEHAVIORAL: Positive reinforcement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CD19/CD20 Dual-CAR-T in B-cell Non-Hodgkin's Lymphoma Patients.
Status: SUSPENDED
Conditions: B-cell Non-Hodgkin's Lymphoma
Interventions: BIOLOGICAL: CD19/CD20 Dual-CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Utidelone Versus Docetaxel in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Interventions: DRUG: Utidelone Injection|DRUG: Docetaxel Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DaZhu Rhodiola Rosea Capsule for Coronary Artery Disease With Angina Pectoris
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: DaZhu Rhodiola Rosea Capsule|DRUG: DaZhu Rhodiola Rosea Simulation Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Moderate Dose Hydroxyurea for Secondary Stroke Prevention in Children With Sickle Cell Disease in Sub-Saharan Africa
Status: COMPLETED
Conditions: Sickle Cell Disease|Sickle Cell Anemia|Stroke
Interventions: DRUG: Moderate Dose Hydroxyurea|DRUG: Low Dose Hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Study of ChAdOx1 85A Vaccination With and Without MVA85A Boost in Healthy Adults
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: ChAdOx1 85A|BIOLOGICAL: MVA85A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A PK Similarity Study of Two Sintilimab Products Produced by Different Processes in Advanced or Metastatic NSCLC Patients
Status: COMPLETED
Conditions: Advanced or Metastatic NSCLC
Interventions: DRUG: Sintilimab (M1b)|DRUG: Sintilimab (approved)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preservation of Residual Beta Cell Mass and Prevention of Celiac Disease in Children With Recent Onset Type 1 Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 1|Remission|Celiac Disease in Children
Interventions: OTHER: withdrawal of gluten from the diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Low Sodium Diet and Behavioral Intervention for Reversing Arterial Stiffening in Overweight Individuals
Status: COMPLETED
Conditions: Cardiovascular Diseases|Obesity
Interventions: BEHAVIORAL: Low Sodium Diet|BEHAVIORAL: Regular Sodium Intake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Local Infiltration Analgesia With and Without EXPAREL Following Total Knee Arthroplasty
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: EXPAREL|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evoked Responses as Pharmacodynamic Biomarkers in Healthy and Schizophrenic Participants (MK-4334-007)
Status: COMPLETED
Conditions: Cognitive Impairment Associated With Schizophrenia
Interventions: DRUG: Nicotine patch|DRUG: MK-4334|DRUG: Placebo patch|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Re-treatment Safety of Radium-223 Dichloride in Castration-resistant Prostate Cancer With Bone Metastases
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: Radium-223 dichloride (Xofigo, BAY88-8223)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tongxinluo Improve High on Clopidogrel Platelet Reactivity Patients With Coronary Heart Disease
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Tongxinluo|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of SC0062 in the Treatment of Chronic Kidney Disease
Status: RECRUITING
Conditions: Diabetic Kidney Disease|IgA Nephropathy
Interventions: DRUG: Placebo of SC0062|DRUG: SC0062 low dose|DRUG: SC0062 medium dose|DRUG: SC0062 high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trigeminal Nerve Stimulation (TNS) in the Treatment of Fibromyalgia
Status: UNKNOWN
Conditions: Fibromyalgia
Interventions: DEVICE: Trigeminal nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: Azacitidine|OTHER: Best Practice|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|DRUG: Cytarabine|DRUG: Daunorubicin Hydrochloride|DRUG: Decitabine and Cedazuridine|PROCEDURE: Echocardiography|DRUG: Enasidenib|DRUG: Gilteritinib|DRUG: Liposome-encapsulated Daunorubicin-Cytarabine|PROCEDURE: Multigated Acquisition Scan|PROCEDURE: Mutation Carrier Screening|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Adding Sitagliptin or Pioglitazone to Type 2 Diabetes Mellitus Insufficiently Controlled With Metformin and Sulfonylurea
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Sitagliptin|DRUG: pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: eIMPACT Trial: Modernized Collaborative Care to Reduce the Excess CVD Risk of Older Depressed Patients
Status: COMPLETED
Conditions: Depression|Major Depressive Disorder|Dysthymic Disorder|Depressive Symptoms|Cardiovascular Diseases|Heart Diseases|Coronary Artery Disease|Stroke
Interventions: BEHAVIORAL: Beating the Blues (BtB)|BEHAVIORAL: Problem Solving Treatment in Primary Care (PST-PC)|DRUG: Antidepressant Medications|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Virtual Reality and Relaxation for the Treatment of Generalized Anxiety Disorders: a Comparative Study With Standard Relaxation
Status: COMPLETED
Conditions: Generalized Anxiety Disorders
Interventions: BEHAVIORAL: Relaxation optimized virtual reality|BEHAVIORAL: Classical relaxation (without Virtual Reality)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: the Psychological Interventions for Alleviating Anxiety and Depressive Emotion Among Oocyte Retrieval Patients
Status: NOT_YET_RECRUITING
Conditions: Infertility|in Vitro Fertilization|Mental Health|Anesthesia, General
Interventions: OTHER: Psychological interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Oxymetazoline and Energy-Based Therapy in Participants With Rosacea
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: Oxymetazoline HCL 1.0% Cream|DEVICE: Energy-Based Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Cognitive Intervention Enriched With Leisure Activities in Persons With Subjective Cognitive Decline
Status: ACTIVE_NOT_RECRUITING
Conditions: Subjective Cognitive Decline
Interventions: BEHAVIORAL: ENGAGE SPANISH/MUSIC|BEHAVIORAL: ENGAGE DISCOVERY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Aerosure and Six Minute Walk Distance in Severe COPD
Status: COMPLETED
Conditions: COPD
Interventions: DEVICE: Aerosure 25 Hz|DEVICE: Aerosure Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sentinel Lymph Node Biopsy for Cutaneous Squamous Cell Carcinoma of the Head and Neck
Status: RECRUITING
Conditions: Squamous Cell Carcinoma|Nonmelanoma Skin Cancer|Cutaneous Squamous Cell Carcinoma
Interventions: PROCEDURE: sentinel lymph node biopsy (SLNB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Open-Label, Chronic Exposure, Safety Study of CLONICEL (Clonidine HCl Sustained Release) in Children and Adolescents With Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: CLONICEL (Clonidine HCl sustained release)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of CJ-30060 in Healthy Volunteers
Status: UNKNOWN
Conditions: Healthy Subjects
Interventions: DRUG: Exforge® tab 5/160mg, Crestor® tab 10mg|DRUG: CJ-30060 5/160/10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robot-assisted Thoraco-laparoscopic Esophagectomy Versus Open Transthoracic Esophagectomy
Status: COMPLETED
Conditions: Esophageal Carcinoma|Esophageal Cancer
Interventions: PROCEDURE: Esophagectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Restoring Black Triangle With Bioclear Matrix Versus Celluloid Conventional Matrix Method
Status: UNKNOWN
Conditions: Gingival Black Triangle
Interventions: PROCEDURE: Conventional celluloid matrix technique in management of black triangle|PROCEDURE: Bioclear cervical matrix with injection molding technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Autologous Adipose Derived Mesenchymal Stromal Cells (AD-MSC) Transplantation in Ultra Filtration Failure (UFF)
Status: COMPLETED
Conditions: Ultra Filtration Failure
Interventions: BIOLOGICAL: Intravenous injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IDH2 (AG 221) Inhibitor in Patients With IDH2 Mutated Myelodysplastic Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelodysplastic Syndromes|Leukemia Acute Myeloid
Interventions: DRUG: AG-221
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Erythropoietin on Neurodevelopmental Outcomes in Very Preterm Infants With Intraventricular Hemorrhage
Status: COMPLETED
Conditions: Premature Infants
Interventions: DRUG: Erythropoietin|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Celecoxib Efficacy And Safety Versus Diclofenac In Acute Pain Due To Cervical Sprain Related To A Traffic Accident
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: Celecoxib|DRUG: oral Diclofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Helping Invested Families Improve Veterans Experiences Study
Status: COMPLETED
Conditions: Caregiver|Disabled Veterans|Referred to Long-term Care|Residing at Home|Hospice Ineligible
Interventions: BEHAVIORAL: Helping Invested Families Improve Veterans Experiences - Control|BEHAVIORAL: Helping Invested Families Improve Veterans Experiences - HI FIVES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Palatal Wound Healing in Diabetic and Non-diabetic Patients
Status: RECRUITING
Conditions: Palate; Wound|Wound Heal|Diabetes
Interventions: PROCEDURE: Palatal Wound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Useability Test to the Wearable Walking-assist Robot (GEMS-H) for Normal Adults Including the Elderly
Status: COMPLETED
Conditions: Gait Disorders in Old Age
Interventions: DEVICE: Training with Gait Enhancing and Motivating System (GEMS-H) Robot
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Integrating Sleep, Nightmare and PTSD Treatments
Status: RECRUITING
Conditions: Nightmares|PTSD
Interventions: BEHAVIORAL: Exposure, Relaxation, and Rescripting Therapy|BEHAVIORAL: Cognitive Processing Therapy - Cognitive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Cost of Remote Monitoring of Patients With Cardiac Resynchronization Therapy
Status: COMPLETED
Conditions: Heart Failure|Cardiac Resynchronization Therapy
Interventions: OTHER: CRT-P or CRT-D standard remote monitoring|OTHER: CRT-P or CRT-D full remote monitoring|OTHER: Symptoms and signs remote monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Acupuncture Functional Magnetic Resonance Imaging (fMRI) Study on Chronic Pain: Response Reliability and Dose Effect
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PHP and Immunotherapy in Metastasized UM
Status: RECRUITING
Conditions: Uveal Melanoma, Metastatic
Interventions: DRUG: Ipilimumab and nivolumab|DRUG: Melphalan chemosaturation via percutaneous hepatic perfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oncolytic Virotherapy Plus PD-1 Inhibitor and Lenvatinib for Patients With Advanced Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: H101|DRUG: Tislelizumab|DRUG: lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chinese Tuina Therapy for Treatment of Chronic Nonspecific Low Back Pain
Status: UNKNOWN
Conditions: Chronic Nonspecific Low Back Pain
Interventions: BEHAVIORAL: Chinese Tuina therapy|DRUG: Flurbiprofen Cataplasms group (FCG).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does PEP Compensate the Reduction of Tidal Volume During One Lung Ventilation?
Status: COMPLETED
Conditions: Lung Neoplasms|Pulmonary Disease
Interventions: PROCEDURE: One-Lung ventilation|PROCEDURE: One-Llung ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Chemotherapy and Radiation Therapy Compared to Chemotherapy and Radiation Therapy Plus MEDI4736 (Durvalumab) Immunotherapy for Bladder Cancer Which Has Spread to the Lymph Nodes, INSPIRE Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Bladder Urothelial Carcinoma|Stage III Bladder Cancer AJCC v8
Interventions: PROCEDURE: Biopsy of Bladder|PROCEDURE: Biospecimen Collection|DRUG: Cisplatin|PROCEDURE: Computed Tomography|PROCEDURE: Cystoscopy|BIOLOGICAL: Durvalumab|DRUG: Fluorouracil|DRUG: Gemcitabine Hydrochloride|PROCEDURE: Magnetic Resonance Imaging|DRUG: Mitomycin|OTHER: Patient Observation|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Walnut and Immunity Study
Status: RECRUITING
Conditions: Immune Response|Upper Respiratory Tract Infection
Interventions: DIETARY_SUPPLEMENT: walnuts|DIETARY_SUPPLEMENT: Habitual diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: DRUG: Intralipid, 20% Intravenous Emulsion|DIETARY_SUPPLEMENT: MitoQ|DRUG: Salbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine-propofol-remifentanil Anaesthesia and Reactivity to Noxious Stimuli
Status: COMPLETED
Conditions: Anaesthesia
Interventions: DRUG: Dexmedetomidine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Preovulatory Uterine Flushing With Saline as a Treatment for Unexplained Infertility
Status: UNKNOWN
Conditions: Unexplained Infertility|Infertility
Interventions: BEHAVIORAL: Detection of ovulation|PROCEDURE: Uterine flushing|PROCEDURE: Vaginal flushing|BEHAVIORAL: Sexual intercourse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II/III Study Evaluating the Effect of IL-2 on Preservation of the CD4 T-Lymphocytes After Interruption of Antiretroviral Treatment in HIV-Infected Patients With CD4 T-Lymphocyte Count Greater Than 500 Cells/mm3 Who Received Antiretroviral Tx
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Interleukin 2|DRUG: HAART|DRUG: Treatment interruption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Niacin on Transport of HDL and Relationship to Atherogenic Lipoproteins and Lipolysis
Status: COMPLETED
Conditions: Dyslipidemias
Interventions: DRUG: Niacin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Bioequivalence of 70-mg Alendronate and 70-mg Alendronate in Combination With 5600 IU Vitamin D (MK0217A-253)
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: alendronate sodium+vitamin D combination|DRUG: Comparator: alendronate|DIETARY_SUPPLEMENT: Comparator: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Macular Pigment and Glare Disability
Status: COMPLETED
Conditions: Vision, Entoptic
Interventions: DIETARY_SUPPLEMENT: 12 mg Lutein + Zeaxanthin|DIETARY_SUPPLEMENT: Visually identical placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Between Technosphere/Insulin Inhalation Powder Versus Rapid Acting Insulin in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Type 2
Interventions: DRUG: Technosphere Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-exercise Recovery After Dietary Protein Ingestion in Healthy Young Men (Meat-Milk Study)
Status: COMPLETED
Conditions: Skeletal Muscle Hypertrophy
Interventions: DIETARY_SUPPLEMENT: Lean minced meat (beef)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intubating Laryngeal Mask vs Direct Laryngoscopy: a Crossover Randomized Controlled Preterm Manikin Trial
Status: NOT_YET_RECRUITING
Conditions: Neonatal Disease|Intubation; Difficult or Failed
Interventions: DEVICE: Intubating laryngeal mask|DEVICE: Direct laryngoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial Of Endoscopic Ultrasound-Guided Fine-Needle Aspiration With And Without A Stylet
Status: UNKNOWN
Conditions: Mediastinal or Intra-abdominal Lymphadenopathy,|Pancreatic Masses,|Left Adrenal Masses,|Gastrointestinal Submucosal Lesions, and|Liver Masses
Interventions: DEVICE: EUS - FNA with stylet|DEVICE: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Magnesium and Vascular Stiffness
Status: UNKNOWN
Conditions: Vascular Stiffness|Blood Pressure
Interventions: DIETARY_SUPPLEMENT: Magnesium Citrate|DIETARY_SUPPLEMENT: Magnesium Sulfate|DIETARY_SUPPLEMENT: Magnesium Oxide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Diaphragmatic Myofascial Release on Thoracic Angle and Pulmonary Functions in Hyperkyphotic Adolescents
Status: COMPLETED
Conditions: Adolescent Kyphosis
Interventions: OTHER: therapeutic exercise program|OTHER: diaphragmatic myofascial release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Answer ALS: Individualized Initiative for ALS Discovery
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis|Primary Lateral Sclerosis|Flail Arm ALS|Progressive Muscular Atrophy|Monomelic Amyotrophy|Motor Neuron Disease|Asymptomatic ALS Gene Carriers|Healthy Controls
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pediatric Elective Intubation With and Without Muscle Relaxation Utilizing the Shikani Optical Stylet
Status: TERMINATED
Conditions: Intubation,Endotracheal
Interventions: DRUG: Cisatracurium|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of GED-0507-34-Levo for Treatment of UC
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: DRUG: GED-0507-34-Levo 80 mg|DRUG: GED-0507-34-Levo 160 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Chronic Rhinosinusitis on the Index of Ciliary Beat Efficiency Using Fluorescent Nanosticks: (R-IMPAC)
Status: NOT_YET_RECRUITING
Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: PROCEDURE: nasal brushing and bacteriological sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immunogenicity and Safety Study of a GlaxoSmithKline Biologicals' Candidate Influenza Vaccine in Healthy Children
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza vaccine GSK2321138A|BIOLOGICAL: Fluarix™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Magnesium Variations and Cardiometabolic Risk in Patients With Antipsychotic Drugs
Status: UNKNOWN
Conditions: Schizophrenia|Schizoaffective Disorder|Bipolar Disorder
Interventions: BIOLOGICAL: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Mericitabine in Combination With Telaprevir and Peginterferon Alfa-2a / Ribavirin in Participants With Chronic Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Ribavirin|DRUG: Mericitabine|DRUG: Peginterferon Alfa-2a|DRUG: Placebo|DRUG: Telaprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation to Reduce Tics
Status: COMPLETED
Conditions: Tourette Syndrome
Interventions: DEVICE: Sham Repetitive Transcranial Magnetic Stimulation|DEVICE: Active Repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of NT-proBNP Testing to Guide Heart Failure Therapy in the Outpatient Setting.
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: OTHER: Drug therapy for HF|OTHER: NT-proBNP guided HF therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Vagal Stimulation in Exposure and Response Prevention for Obsessive Compulsive Disorder
Status: UNKNOWN
Conditions: Obsessive Compulsive Disorder
Interventions: BEHAVIORAL: Exposure and Response Prevention|DEVICE: Cold face gel mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Internet Therapeutic Intervention on A1C Levels in Type 2 Diabetes Mellitus (DM)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: Internet Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Exploratory Study of Gemcitabine Hydrochloride Oral Formulation (D07001-F4) in Subjects With Malignant Tumors
Status: COMPLETED
Conditions: Malignant Tumors
Interventions: DRUG: Gemcitabine HCl Oral Formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Diameter Changes of Retinal Vessels During Hypoxia
Status: COMPLETED
Conditions: Diabetes Mellitus Type 1|Diabetic Maculopathy
Interventions: OTHER: COX inhibitor|OTHER: L-NG-monomethyl arginine citrate|OTHER: COX inhibitor + L-NG-monomethyl arginine citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect and Safety of Recombinant Human Adenovirus Type 5 in Advanced HCC With Stable Disease After Sorafenib Treatment
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Recombinant Human Adenovirus Type 5 injection|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Reslizumab in Participants With Uncontrolled Asthma and Elevated Blood Eosinophils
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Reslizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Partial Breast Re-irradiation in Women in Women With Locally Recurrent Breast Cancer Previously Treated With Conservative Surgery and Whole Breast Irradiation
Status: RECRUITING
Conditions: Breast Cancer|Recurrent
Interventions: RADIATION: Partial breast re-irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial
Status: COMPLETED
Conditions: Ventilator Associated Pneumonia|Infections|C-Difficile|Antibiotic-associated Diarrhea|Diarrhea
Interventions: DRUG: L. rhamnosus GG - Probiotic|DRUG: Placebo - Microcrystalline Cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity and Safety of Two-Dose Series of Menactra® in Japanese Healthy Adult Subjects
Status: COMPLETED
Conditions: Meningitis|Meningococcal Meningitis|Meningococcal Infections
Interventions: BIOLOGICAL: Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION