pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Assess the Effects of PT001 and PT005 MDI on Specific Image Based Parameters in Subjects With Moderate to Severe COPD
Status: COMPLETED
Conditions: COPD, Chronic Obstructive Pulmonary Disease
Interventions: DRUG: GP MDI (PT001) 14.4 μg|DRUG: FF MDI (PT005) 9.6 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Nature-based Group Intervention on Quality-of-life in Lonely Older People Living in Assisted Living Facities
Status: RECRUITING
Conditions: Loneliness
Interventions: OTHER: Nature-based social prescribing group intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: High-flow Nasal Cannula Oxygenation During Rapid Sequence Induction in Children
Status: RECRUITING
Conditions: Pediatric Surgery|Rapid Sequence Induction
Interventions: PROCEDURE: Optiflow - HFNO|PROCEDURE: Classic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Dosage Exploration and Pharmacokinetics for HA121-28 Tablets
Status: UNKNOWN
Conditions: Advanced Solid Tumor
Interventions: DRUG: HA121-28 tablets|DRUG: HA121-28 tablets|DRUG: HA121-28 tablets|DRUG: HA121-28 tablets|DRUG: HA121-28 tablets|DRUG: HA121-28 tablets|DRUG: HA121-28 tablets|DRUG: HA121-28 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety Follow-Up Study of SCM-AGH in Subjects Who Participated and Administered SCM-AGH in to Severe Atopic Dermatitis Clinical Trials
Status: ENROLLING_BY_INVITATION
Conditions: Dermatitis, Atopic
Interventions: OTHER: Not Applicable (Observational Study)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the Diagnostic Efficacy of "Real Time" Niris 1300e Optical Coherence Tomography (OCT) Imaging System in the Management of Pre-invasive and Invasive Neoplasia of the Uterine Cervix
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia|Cervix Cancer|Cervical Dysplasia|CIN|Human Papillomavirus
Interventions: DEVICE: NIRIS 1300e
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Limited-efficacy Testing of SDS and NEMOST for Early Onset Neuromuscular Scoliosis
Status: COMPLETED
Conditions: Neuromuscular Scoliosis|Distraction System|Growth Friendly System
Interventions: DEVICE: SDS|DEVICE: NEMOST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Evolution of Visual Acuity Measured by Electronic Tablet / Computer of Exudative AMD Patients
Status: UNKNOWN
Conditions: Macular Degeneration Exudative Eye Bilateral
Interventions: OTHER: By comparing the evolution of the visual acuity curves.|OTHER: By comparing the evolution of the curves.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Nicotinamide in Hemodialysis Patients With Hyperphosphatemia
Status: COMPLETED
Conditions: Chronic Kidney Disease|Hemodialysis|Hyperphosphatemia
Interventions: DRUG: Nicotinamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cannabis Inhalation: Effects on Cardiovascular Function During Rest and Exercise
Status: ACTIVE_NOT_RECRUITING
Conditions: Cannabis|Cardiovascular Risk Factor
Interventions: DRUG: Cannabis|DRUG: Cannabis|DRUG: Cannabis|DRUG: Cannabis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Recruitment Messages for Current Smokers Recently Diagnosed With Cancer
Status: COMPLETED
Conditions: Tobacco Smoking|Health Behavior
Interventions: BEHAVIORAL: Proximal|BEHAVIORAL: Distal|BEHAVIORAL: Cost|BEHAVIORAL: Benefit|BEHAVIORAL: Loss|BEHAVIORAL: Gain|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ED90 of 0.75% Bupivacaine for Bilateral Tubal Ligation (BTL)
Status: WITHDRAWN
Conditions: Pain
Interventions: DRUG: Hyperbaric bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of PET Imaging Patterns With PSMA and AR Expression in Prostate Cancer and Bladder Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: PSMA PET Scan|DIAGNOSTIC_TEST: FDHT PET Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Emotional Processing in Healthy Volunteers in the Presence of an Investigational Anxiolytic
Status: COMPLETED
Conditions: Depressive Disorder and Anxiety Disorders
Interventions: DRUG: Citalopram|DRUG: GSK424887|DRUG: Plactebo To Match
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Home Base Telemonitoring in Gastrointestinal, Genitourinary, or Gynecologic Cancer Patients Undergoing Abdominal Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Digestive System Carcinoma|Genitourinary System Carcinoma|Malignant Female Reproductive System Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Best Practice|PROCEDURE: Functional Assessment|OTHER: Medical Device Usage and Evaluation|PROCEDURE: Nutritional Assessment|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|OTHER: TapCloud
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Observational Study of Methoxy Polyethylene Glycol-Epoetin Beta (Mircera) in Stage V Chronic Kidney Disease Participants on Hemodialysis
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Methoxy polyethylene glycol epoetin beta
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Determine the Safety and Feasibility of Utilizing the CD Leycom Pressure/Conductance Catheter to Determine Optimal LV Pacing Site
Status: WITHDRAWN
Conditions: Heart Failure
Interventions: PROCEDURE: Pressure/Conductance Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: D-Light Intervention
Status: COMPLETED
Conditions: 25-hydroxyvitamin D Concentration (Vitamin D Status)
Interventions: DIETARY_SUPPLEMENT: Fortified milk (10µg vitamin D3)|DIETARY_SUPPLEMENT: Unfortified milk (placebo)|DIETARY_SUPPLEMENT: 10µg vitamin D3 supplement|DIETARY_SUPPLEMENT: Placebo supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of ZG006 in Participants With Small Cell Lung Cancer or Neuroendocrine Carcinoma
Status: RECRUITING
Conditions: Small Cell Lung Cancer|Neuroendocrine Carcinoma
Interventions: BIOLOGICAL: ZG006
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of AR/101 in Accelerating Re-epithelialization of Split Thickness Wounds
Status: UNKNOWN
Conditions: Wounds and Injuries
Interventions: DRUG: AR/101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combine Transcranial Direct Current Stimulation and Neuromuscular Electrical Stimulation on Stroke Patients
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Combination of tDCS and NMES|DEVICE: Combination of tDCS and sham NMES|DEVICE: Combination of sham tDCS and sham NMES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Education to Promote Self-management in Pain Therapy
Status: UNKNOWN
Conditions: Patient Empowerment
Interventions: BEHAVIORAL: Micro-training to promote self-management in pain therapy|OTHER: Sham intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Raloxifene Plus Cholecalciferol and Cholecalciferol Alone on the Bone Mineral Density in Postmenopausal Women With Osteopenia
Status: COMPLETED
Conditions: Postemenopusal Women With Osteopenia
Interventions: DRUG: Raloxifene plus cholecalciferol|DRUG: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MR Assessment of Hepatic Hydatid Disease
Status: UNKNOWN
Conditions: Cystic Echincoccosis|Hydatid Disease
Interventions: OTHER: MRI scan (not involving ionising radiation)|OTHER: Ultrasound scan (not involving ionising radiation)|OTHER: Ex vivo MRI scan of cyst fluid sample|OTHER: Aspiration of cyst fluid|OTHER: Blood test for confirmation of serum IgG levels consistent with hydatid infection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prospective, Multi-Center Clinical Outcomes Study Evaluating the chronOS Strip Combined With Bone Marrow Aspirate
Status: COMPLETED
Conditions: Degeneration of Lumbar Intervertebral Disc
Interventions: DEVICE: chronOS Strip
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Oral T3 Normalize Thyroid Hormone Levels Following Cardiopulmonary Bypass in Children?
Status: COMPLETED
Conditions: Low T3 Syndrome
Interventions: DRUG: Oral T3 Low dose|DRUG: Placebo|DRUG: Oral T3 high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Follow-up Strategies for Fragile Patients With Decompensated Heart Failure
Status: TERMINATED
Conditions: Heart Failure; With Decompensation|Fragility
Interventions: OTHER: Management Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Active Drain Line Clearance on Catheter-Associated Bacteriuria
Status: WITHDRAWN
Conditions: Critical Illness|Burns|Surgery|Urinary Tract Infections|Bacteriuria
Interventions: DEVICE: Standard of Care|DEVICE: DLC Group|DEVICE: DLCS Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: FMT in Uncomplicated Diverticulitis
Status: RECRUITING
Conditions: Diverticulitis|Uncomplicated Diverticular Disease
Interventions: BIOLOGICAL: Fecal Microbiota Transplantation (FMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Open-label Study to Evaluate the Activity of Etavopivat on Transcranial Doppler Velocities in Pediatric Patients With Sickle Cell Disease Who Are at Increased Risk for Primary Stroke
Status: RECRUITING
Conditions: Sickle Cell Disease
Interventions: DRUG: Etavopivat|DRUG: Hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Methylprednisolone Per os Versus IV for the Treatment of Multiple Sclerosis (MS) Relapses
Status: UNKNOWN
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: methylprednisolone PO|DRUG: methylprednisolone IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability of BIBR 953 ZW IV and Bioavailability of BIBR 1048 Tablet and Solution in Healthy Males
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIBR 953 ZW IV|DRUG: BIBR 1048 MS tablet|DRUG: BIBR 1048 MS oral solution|DRUG: BIBR 953 ZW IV Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Methyldopa for Reduction of DQ8 Antigen Presentation in At-Risk Subjects for Type 1 Diabetes
Status: WITHDRAWN
Conditions: Type1 Diabetes Mellitus
Interventions: DRUG: Methyldopa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Probiotics on Response to Therapy and on Adverse Effect in Patients Treated With Colchicine for Familial Mediterranean Fever.
Status: WITHDRAWN
Conditions: Familial Mediterranean Fever (FMF )
Interventions: DIETARY_SUPPLEMENT: probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Niraparib as Maintenance Therapy Following First-Line Platinum-Based Chemotherapy in Patients With Extensive Stage Small Cell Lung Cancer
Status: TERMINATED
Conditions: Extensive-stage Small Cell Lung Cancer
Interventions: DRUG: ZL-2306(nirapairb)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TNF-Inhibitor as Immune Checkpoint Inhibitor for Advanced MELanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: COMBINATION_PRODUCT: Nivolumab+Ipilimumab in combination with Anti TNF-α Certolizumab|COMBINATION_PRODUCT: Nivolumab+Ipilimumab in combination with Anti TNF-α Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antimicrobial Susceptibility Testing Guided Therapy Versus Empirical Therapy for the Rescue Treatment of Helicobacter Pylori Infection
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: susceptibility guided therapy|DRUG: personal medication history guided therapy|DRUG: salvage treatment for failed eradication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate LAE102 in Healthy Subjects and Subjects With Overweight Obesity
Status: NOT_YET_RECRUITING
Conditions: Obesity
Interventions: DRUG: LAE102 injection|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Platelet Inhibition With Ticagrelor 60 mg Versus Ticagrelor 90 mg in Elderly Patients With ACS
Status: COMPLETED
Conditions: Acute Coronary Syndrome|STEMI|NSTEMI|Coronary Artery Disease|Myocardial Infarction
Interventions: DRUG: Ticagrelor 90mg|DRUG: Ticagrelor 60 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medical and Serological Follow-up of the Staff of the Paris Saint-Joseph Hospital Group Infected With Severe Acute Respiratory Syndrome Coronavirus 2.
Status: COMPLETED
Conditions: COVID-19
Interventions: OTHER: Serology test follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Renal Anatomy on Shock Wave Lithotripsy Outcomes for Lower Pole Kidney Stones
Status: COMPLETED
Conditions: Urolithiasis|Urinary Lithiasis|Kidney Calculi
Interventions: DEVICE: SWL - Compact Delta Dornier Med Tech
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Confirmatory Study of DSP-5423P in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: DSP-5423P Placebo|DRUG: DSP-5423P 40mg|DRUG: DSP-5423P 80mg|DRUG: DSP-5423P Placebo-to-Flex|DRUG: DSP-5423P Active-to-Flex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Bendamustine Hydrochloride for the Treatment of Pediatric Patients With Relapsed or Refractory Acute Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hand OA AND Methotrexate Use
Status: TERMINATED
Conditions: Reduction in Pain|Reduction of Inflammation|Improvement in Function
Interventions: DRUG: 25 mg/week oral methotrexate tablets|DRUG: 25mg/week oral placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Mirabegron on Bladder Compliance
Status: ACTIVE_NOT_RECRUITING
Conditions: Patients With Low Bladder Compliance of 20ml/H2O or Less Despite Taking Anticholinergics
Interventions: DRUG: Mirabegron (beta3-adrenoceptor agonist), Anticholinergics
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aspirin for Treatment of Multiple Sclerosis-Related Fatigue
Status: TERMINATED
Conditions: Multiple Sclerosis|Fatigue
Interventions: DRUG: High Dose Aspirin (1300 mg/day)|DRUG: Low Dose Aspirin (162 mg/day)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Speaking Aloud After Abdominal Surgery.
Status: COMPLETED
Conditions: Postoperative Respiratory Complications
Interventions: DEVICE: Positive expiratory pressure|OTHER: Speaking loudly during about 3 minutes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Contingency Management, Quitting Smoking, and ADHD
Status: COMPLETED
Conditions: Cigarette Smoking|Smoking Cessation
Interventions: BEHAVIORAL: Contingency Management (CM)|DRUG: Transdermal nicotine skin patches (i.e. Habitrol)|OTHER: Supportive Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Supplementation of Astaxanthin on Skin Photoaging, Hydration and Elasticity
Status: RECRUITING
Conditions: Photoaging
Interventions: DIETARY_SUPPLEMENT: Astaxanthin 6 mg daily|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screening for Ovarian Malignancy
Status: COMPLETED
Conditions: Early Detection of Ovarian Cancer
Interventions: DIAGNOSTIC_TEST: Assesment of Different NEoplasias in the adenexa model|DIAGNOSTIC_TEST: Risk of malignancy index|DIAGNOSTIC_TEST: Histopathologic examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Listening To Music And Foot Reflexology in Children During Perioperative Period
Status: COMPLETED
Conditions: Perioperative Period
Interventions: OTHER: Music Listening Application|OTHER: Foot Reflexology Practice:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Exploratory Study of the Effects of a Single Dose of QAX576 (an Interleukin-13 Monoclonal Antibody) on Simulated Hayfever
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: QAX576|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of In-between Meal Products on Cognitive Function in the Elderly
Status: RECRUITING
Conditions: Cognitive Function
Interventions: DIETARY_SUPPLEMENT: Minimeal product|DIETARY_SUPPLEMENT: Reference product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Real-time Monitoring of Cortisol - Comparison of Cortisol Levels in Four Biological Fluids
Status: RECRUITING
Conditions: Adrenal Insufficiency|Cushing Syndrome|Hyperaldosteronism
Interventions: OTHER: 24 hours sampling of 4 biological fluids (blood, ISF, sweat and saliva)|OTHER: 24 hours sampling of ISF or sweat (after validating the correlation with blood)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: HPV (Human Papilloma Virus) Vaccination After Treatment of Anal Intraepithelial Neoplasia (AIN)
Status: COMPLETED
Conditions: AIN|HIV
Interventions: BIOLOGICAL: Gardasil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial to Determine the MTD of HM781-36B in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Malignancies
Interventions: DRUG: HM781-36B tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temsirolimus and Irinotecan for Treatment Resistant Patients With Metastatic Colorectal Cancer and KRAS Mutations
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Irinotecan|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction Between Rifampin and Fluvastatin
Status: COMPLETED
Conditions: Drug-drug Interaction
Interventions: DRUG: rifampin IV|DRUG: Rifadin 300Mg Capsule|DRUG: Fluvastatin 20 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Investigating the Safety, Tolerability and Efficacy of Amorphous Calcium Carbonate (ACC) on the Treatment of Subjects With CRPC
Status: WITHDRAWN
Conditions: Castrate Resistant Prostate Cancer With Bone Metastasis
Interventions: DRUG: Amorphous calcium carbonate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of ALLO-501A Anti-CD19 Allogeneic CAR T Cells in Adults With Relapsed/Refractory Large B Cell Lymphoma, Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma (ALPHA2)
Status: RECRUITING
Conditions: Relapsed or Refractory Large B Cell Lymphoma, Relapsed or Refractory Chronic Lymphocytic Leukemia, Relapsed or Refractory Small Lymphocytic Lymphoma
Interventions: GENETIC: ALLO-501A|BIOLOGICAL: ALLO-647|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NEURO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
Status: COMPLETED
Conditions: Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
Interventions: DRUG: Eplontersen|DRUG: Inotersen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Spinal Flexion in the Lateral Decubitus Position on the Unilaterality During Spinal Anesthesia
Status: COMPLETED
Conditions: Spinal Anesthesia
Interventions: OTHER: lateral decubitus position with full spinal flexion|OTHER: lateral decubitus position without spinal flexion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Comparison of TACE Combination With and Without EBRT for Advanced HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: Transcatheter arterial chemoembolization|RADIATION: External- beam radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy
Status: UNKNOWN
Conditions: Transient Hypoparathyroidism
Interventions: DRUG: phosphate and betamethasone acetate, 2 mL.|DRUG: saline 0.9% NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Wiki Head CT Choice Study: Adaptation of US Two Decision Aids to a Québec Local Context
Status: UNKNOWN
Conditions: Mild Traumatic Brain Injury|Emergencies|Decision-making
Interventions: DEVICE: Real-life clinical meetings
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Knee Connect: Physiotherapy Exercise Performance With Visual Feedback After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Arthroplasty|Replacement|Knee
Interventions: DEVICE: Knee Connect + Visual Feedback System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Application Time of Plaster-of-Paris Splint Packs Compared to Bulk Supplies Following Standard Orthopaedic Procedure
Status: COMPLETED
Conditions: Post-operative Time Saving Techniques
Interventions: DEVICE: Pre-prepared Splint Pack composed by Medline|DEVICE: Bulk splint supplies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prospective Randomized Comparative Study of the Treatment of Multisegmental Fibrostenosing Crohn's Disease.
Status: UNKNOWN
Conditions: Crohn Disease|Stricture; Bowel
Interventions: PROCEDURE: Surgical resection|PROCEDURE: Endoscopic stricturotomy|PROCEDURE: Strictureplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Efficacy and Safety of MEGF0444A Dosed to Progression in Combination With Bevacizumab and mFOLFOX-6 in Participants With Previously Untreated Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: 5-Fluorouracil|DRUG: Bevacizumab|DRUG: Folinic acid|DRUG: MEGF0444A|DRUG: Oxaliplatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Atezolizumab Alone or Atezolizumab Plus Bevacizumab in People With Advanced Alveolar Soft Part Sarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Alveolar Soft Part Sarcoma|Unresectable Alveolar Soft Part Sarcoma
Interventions: DRUG: Atezolizumab|BIOLOGICAL: Bevacizumab|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dose of Activated Recombinant Human Factor VII for Treatment of Mild/Moderate Joint Bleeds in Haemophilia Patients With Inhibitors
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A With Inhibitors|Haemophilia B With Inhibitors
Interventions: DRUG: activated recombinant human factor VII
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hypothermia After Cardiac Arrest - Effects on Myocardial Function and Inflammatory Response.
Status: COMPLETED
Conditions: Out of Hospital Cardiac Arrest|Inflammatory Response|Ischemia Reperfusion Injury|Hypothermia
Interventions: PROCEDURE: Targeted temperature management|PROCEDURE: Standard care, early treatment of fever
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib, Sintilimab Plus SIRT for Unresectable HCC
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Lenvatinib, sintilimab plus SIRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reproducibility of RNFL and ONH Measurements in OAG With Heidelberg Spectralis SD-OCT Glaucoma Module Premium Edition
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma
Interventions: DEVICE: RNFL and BMO-MRW SD-OCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Posterior Capsule Opacification and Frequency of Nd:YAG Treatment and of Two Microincision IOLs: Hoya iMics NY-60 vs Acrysof SN60WF
Status: COMPLETED
Conditions: Capsule Opacification|Pseudophakia|Cataract
Interventions: PROCEDURE: intraocular lens implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Clinical Trial to Evaluate the Safety and Efficacy of the Addition of Sitagliptin in Participants With Type 2 Diabetes Mellitus Receiving Acarbose Monotherapy (MK-0431-130)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin phosphate|DRUG: Comparator: Placebo|DRUG: Acarbose|DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Proteomic Profiling of Coronary Thrombus in Acute Myocardial Infarction
Status: UNKNOWN
Conditions: Acute Myocardial Infarction|STEMI - ST Elevation Myocardial Infarction
Interventions: OTHER: Time from the onset of symptoms to PCI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: New Periodontitis Treatment Based on Hyaluronic Acid and Melatonin
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: DRUG: Tetracycline-Metronidazole (TM) group|DRUG: TM-Melatonin-Hyaluronic acid (TM-MHa) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Transcranial Direct Current Stimulation to Treat Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DEVICE: transcranial direct current stimulation|DRUG: Sertraline|OTHER: double placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Are Rates of Colectomies, Resections, Mortalities and Cancer Reduced by Home Monitoring of IBD Patients ?
Status: ACTIVE_NOT_RECRUITING
Conditions: Inflammatory Bowel Diseases
Interventions: BEHAVIORAL: At Home Screening procedure On demand|BEHAVIORAL: At Home Screening procedure every 3 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Memantine for Enhanced Stroke Recovery
Status: ACTIVE_NOT_RECRUITING
Conditions: Ischemic Stroke|Upper Extremity Weakness
Interventions: DRUG: Memantine XR|DRUG: Placebo (for memantine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Durham Connects RCT Evaluation
Status: ACTIVE_NOT_RECRUITING
Conditions: Unspecified Child Maltreatment, Suspected|Unspecified Child Maltreatment, Confirmed
Interventions: OTHER: Durham Connects
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Liraglutide on Dietary Lipid Induced Insulin Resistance in Humans
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: DRUG: Liraglutide|DRUG: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Ipatasertib in Participants With Mild, Moderate or Severe Hepatic Impairment Compared to Healthy Participants
Status: COMPLETED
Conditions: Hepatic Insufficiency
Interventions: DRUG: Ipatasertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Programs to Encourage Physical Activity in Individuals With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|Lung Diseases, Obstructive
Interventions: BEHAVIORAL: Lifestyle Activity Program|BEHAVIORAL: Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants With Myelodysplastic Syndrome (MDS) and Anemia Not Receiving Blood Transfusions
Status: RECRUITING
Conditions: Myelodysplastic Syndromes
Interventions: BIOLOGICAL: Luspatercept|BIOLOGICAL: Epoetin Alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Orcinoside With Placebo in Treatment of MDD
Status: COMPLETED
Conditions: Major Depressive Disorder (MDD)
Interventions: DRUG: Orcinoside
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Radiofrequency-treatment on Patients With Facet-joint Pain in Cervical- and Lumbar-columna
Status: COMPLETED
Conditions: Neck Pain|Low Back Pain
Interventions: PROCEDURE: radiofrequency treatment|PROCEDURE: sham neurotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Ciraparantag for Reversal of Anticoagulation Induced by Edoxaban, Apixaban or Rivaroxaban in Healthy Adults
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: Ciraparantag|DRUG: Placebo|DEVICE: Point-of-Care Coagulometer (investigational device)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single and Multiple Ascending Oral Doses of Avenanthramide
Status: RECRUITING
Conditions: Inflammation
Interventions: DRUG: Avenanthramide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nanodiamond-Gutta Percha Composite Biomaterials for Root Canal Therapy
Status: WITHDRAWN
Conditions: Dental Pulp Diseases|Dental Pulp Necrosis|Nerve Root Pain Nec
Interventions: COMBINATION_PRODUCT: ND and AMOX modified Gutta Percha|DEVICE: Gutta Percha
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Subthalamic Stimulation in Tourette's Syndrome
Status: COMPLETED
Conditions: Tourette's Syndrome|Tourette Syndrome|Gilles de la Tourette Syndrome|Tourette Disorder
Interventions: PROCEDURE: STN DBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of the Bispecific Anti-PD-1/PD-L1 Antibody IBI318 Combined With Lenvatinib in NSCLC.
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: IBI318
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy of Using Modified Qing-Ying Decoction in Atopic Dermatitis Children
Status: UNKNOWN
Conditions: Atopic Dermatitis
Interventions: DRUG: Modified Qing-Ying Decoction|DRUG: Identical looking placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
Status: RECRUITING
Conditions: Frontotemporal Lobar Degeneration (FTLD)|Progressive Supranuclear Palsy (PSP)|Corticobasal Degeneration (CBD)|Behavioral Variant Frontotemporal Dementia (bvFTD)|Semantic Variant Primary Progressive Aphasia (svPPA)|Nonfluent Variant Primary Progressive Aphasia (nfvPPA)|FTD With Amyotrophic Lateral Sclerosis (FTD/ALS)|Amyotrophic Lateral Sclerosis|Oligosymptomatic PSP (oPSP)|C9orf72|GRN Related Frontotemporal Dementia|MAPT Gene Mutation|TBK1 Gene Mutation|Oligosymptomatic Progressive Supranuclear Palsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acute Balloon Angioplasty vs. Traditional Early Invasive Treatment of Non-ST-Elevation Myocardial Infarction
Status: TERMINATED
Conditions: Myocardial Infarction
Interventions: PROCEDURE: Primary Percutaneous Coronary Intervention|PROCEDURE: Coronary angiography / Percutaneous coronary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy Evaluation of an ODF Iron Supplement vs an Iron Supplement in Capsules in Subjects With Mild Anemia
Status: RECRUITING
Conditions: Iron Deficiencies
Interventions: DIETARY_SUPPLEMENT: ODF Iron Supplement|DIETARY_SUPPLEMENT: Iron Supplement in Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Selective RPE Laser Treatment (SRT) for Various Macular Diseases
Status: UNKNOWN
Conditions: Age-Related Macular Degeneration|Diabetic Maculopathy|Central Serous Chorioretinopathy
Interventions: PROCEDURE: Selective RPE laser treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability of Darifenacin in Patients Aged > 65 Years With Overactive Bladder
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: Darifenacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does the Disinfection of the Subcutaneous Tissue Reduce the Contamination of the Operative Field by P. Acnes During Primary Shoulder Surgery?
Status: UNKNOWN
Conditions: Shoulder Surgery
Interventions: PROCEDURE: subcutaneous disinfection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Single Doses of ILV-095 in Healthy Japanese Male Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: BIOLOGICAL: ILV-095|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Venetoclax Plus Intensive Chemotherapy in AML and Advanced MDS
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: Venetoclax Oral Tablet|DRUG: Daunorubicin|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplemental Parenteral Nutrition in Pediatric Respiratory Failure
Status: TERMINATED
Conditions: Acute Respiratory Failure With Hypoxia|Malnutrition
Interventions: DRUG: Parenteral Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of and Immune Response to a DNA HIV Vaccine (pGA2/JS7) Boosted With a Modified Vaccinia HIV Vaccine (MVA/HIV62) in Healthy Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: pGA2/JS7 DNA|BIOLOGICAL: Modified vaccinia Ankara/HIV62
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Reduction of Occurence of Acute Kidney Injury (AKI) Through Administration of Glutamine
Status: COMPLETED
Conditions: Cardiac Surgery|Acute Kidney Injury
Interventions: DRUG: L-Alanyl/L-Glutamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab, Tremelimumab and Hypofractionated Radiation Therapy in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Status: TERMINATED
Conditions: Metastatic Head and Neck Squamous Cell Carcinoma|Recurrent Head and Neck Squamous Cell Carcinoma
Interventions: BIOLOGICAL: Durvalumab|OTHER: Laboratory Biomarker Analysis|RADIATION: Stereotactic Body Radiation Therapy|BIOLOGICAL: Tremelimumab|PROCEDURE: Hypofractionated Image-Guided Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-DCFPyL PET/MRI in Regional Nodal&Distant Metastases Detection in Intermediate &HR Prostate Cancer
Status: TEMPORARILY_NOT_AVAILABLE
Conditions: Prostate Cancer
Interventions: DRUG: F18-DCFPyL|DRUG: Gadolinium|PROCEDURE: Positron emission tomography (PET)/Magnetic Resonance Imaging (MRI) Scan
Study Type: EXPANDED_ACCESS
Clinical trial: A Study to Evaluate the Efficacy and Safety of Fremanezumab for Preventive Treatment of Migraine in Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Migraine|Major Depressive Disorder
Interventions: DRUG: Fremanezumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: GreenLight Laser Photoselective Vaporization of the Prostate vs Bipolar Transurethral Vaporization of the Prostate; RCT
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: PROCEDURE: Greenlight laser PVP|PROCEDURE: Bipolar TUVP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effects of JNJ-26489112 on the Photic Induced Paroxysmal Electroencephalogram (EEG) Response in Patients With Photosensitive Epilepsy
Status: COMPLETED
Conditions: Photosensitive Epilepsy
Interventions: DRUG: JNJ-26489112|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Single Incision Laparoscopic Cholecystectomy Using a Flexible Endoscope and Ethicon Manually Articulating Devices (MAD)
Status: WITHDRAWN
Conditions: Cholelithiasis|Pain
Interventions: DEVICE: Flexible endoscope and Ethicon Manually Articulating Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Empagliflozin on NT-Pro Brain Natriuretic Peptide in Heart Failure Patients With Reduced Ejection Fraction
Status: RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: Empagliflozin 10 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess the Efficacy of Esomeprazole 20mg Once Daily in Subjects Who Still Had Heartburn After Receiving Rabeprazole
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease|GERD|Reflux Esophagitis
Interventions: DRUG: esomeprazole 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Different Treatment in Multivessel Non ST Elevation Myocardial Infarction (NSTEMI) Patients: One Stage Versus Multistaged Percutaneous Coronary Intervention (PCI)
Status: UNKNOWN
Conditions: Non ST Segment Elevation MI and Unstable Angina
Interventions: PROCEDURE: One-Stage group|PROCEDURE: Multi-Staged group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SPECTA: Screening Cancer Patients for Efficient Clinical Trial Access
Status: RECRUITING
Conditions: All Tumor Types
Interventions: GENETIC: RP-1828 IMMUcan|GENETIC: RP-1759 AYA/TYA|GENETIC: RP-1843 Arcagen|GENETIC: RP-1920 BioRadon
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p