pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Diaphragmatic Function as a Biomarker
Status: RECRUITING
Conditions: Dyspnea; Asthmatic|COPD|Fibrosis|Pulmonary Hypertension|Asthma|Dyspnea
Interventions: DIAGNOSTIC_TEST: Diaphragm Ultrasound|DIAGNOSTIC_TEST: Intercostal Muscle Ultrasound|DIAGNOSTIC_TEST: Borg scale|DIAGNOSTIC_TEST: MRC Breathlessness Scale|DIAGNOSTIC_TEST: Respiratory Questionaire|DIAGNOSTIC_TEST: GINA classification of Asthma|DIAGNOSTIC_TEST: Measurement of respiratory mouth pressure|DIAGNOSTIC_TEST: SNIP|DIAGNOSTIC_TEST: 6-minute walking distance|DIAGNOSTIC_TEST: 60 seconds sit-to-stand test|DIAGNOSTIC_TEST: Electromyography|DIAGNOSTIC_TEST: Lung Function|DIAGNOSTIC_TEST: CAT-Questionnaire|DIAGNOSTIC_TEST: European Society of Cardiology (ESC)/ European Respiratory Society (ERS) risk group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MK0524 Asthma POC Study (0524-008)(COMPLETED)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Comparator: MK0524 + placebo|DRUG: Comparator: MK0524 + montelukast|DRUG: Comparator: placebo + montelukast|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Treatment of Cadonilimab Combined Albumin-paclitaxel, Cisplatin and Fluorouracil for Resectable Locally Advanced Esophageal Squamous Cell Carcinoma
Status: RECRUITING
Conditions: The Efficacy and Safety of Therapy Efficacy for Locally Advanced ESCC
Interventions: DRUG: Cadonilimab Combined Albumin-paclitaxel, Cisplatin and Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Phytoecdysterone Administration in Subjects With Prediabetes
Status: UNKNOWN
Conditions: PreDiabetes
Interventions: DIETARY_SUPPLEMENT: Ecdysterone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Fluphenazine in Relapsed or Relapsed-and-Refractory Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Fluphenazine HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-Oxidant Supplementation for the Prevention of Acute Mountain Sickness
Status: COMPLETED
Conditions: Acute Mountain Sickness
Interventions: DIETARY_SUPPLEMENT: Anti-oxidant supplementation|DIETARY_SUPPLEMENT: Matched placebo for anti-oxidant supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of LY3454738 in Adults With Chronic Spontaneous Urticaria
Status: TERMINATED
Conditions: Chronic Spontaneous Urticaria
Interventions: DRUG: LY3454738|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Resection Quality of Cerebral Metastases Using Fluorescence Guided Surgery: a Prospective Randomised Study
Status: UNKNOWN
Conditions: Cerebral Metastases|Fluorescence Guided Surgery
Interventions: PROCEDURE: microsurgical resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation in Older Adults With Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D3 50,000 IU|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Isatuximab, Bela Maf, Pom, and Dex in Relapsed/Refractory Multiple Myeloma
Status: NOT_YET_RECRUITING
Conditions: Relapsed Cancer|Refractory Multiple Myeloma|Multiple Myeloma
Interventions: DRUG: Isatuximab|DRUG: Belantamab mafodotin|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence of LF Infection in Districts Not Included in LF Control Activities
Status: COMPLETED
Conditions: Lymphatic Filariases|Onchocerciasis
Interventions: DIAGNOSTIC_TEST: Diagnosis of lymphatic filariasis|DIAGNOSTIC_TEST: Diagnosis of lymphatic Filariasis and onchocerciasis|DIAGNOSTIC_TEST: DEC Patch
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nurse vs General Practitioner Care for Patients Requesting Same Day Consultations in Primary Care
Status: UNKNOWN
Conditions: Acute Disease|Nursing Care|Ambulatory Care|Family Practice
Interventions: PROCEDURE: Nurse practitioner care of patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Chlorhexidine Vaginal Cleansing Versus Iodine Prior to C-section and the Rate of Postoperative Infection
Status: COMPLETED
Conditions: Vaginal Scrubbing
Interventions: OTHER: Chlorhexidine|OTHER: Iodine|OTHER: Antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Multicentric Prospective Validation of a Universal Test to Quantify Apixaban, Rivaroxaban, Danaparoid and Fondaparinux Levels
Status: RECRUITING
Conditions: Anticoagulation|Venous Thromboembolism|Atrial Fibrillation
Interventions: DIAGNOSTIC_TEST: Estimated anticoagulant level (conversion factor x anti-Xa activity)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Research of 18F-Alfatide Ⅱ PET/CT in Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: 18F-Alfatide Ⅱ PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Pregabalin Sustained Release Tablet for Postherpetic Neuralgia
Status: UNKNOWN
Conditions: Postherpetic Neuralgia
Interventions: DRUG: Placebo|DRUG: Pregabalin SR tablet 165mg/day|DRUG: Pregabalin SR tablet 330mg/day|DRUG: Pregabalin SR tablet 660mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A P300 Brain Computer Interface Keyboard to Control Assistive Technology For Use by People With Amyotrophic Lateral Sclerosis
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DEVICE: P300 Brain Computer Interface Keyboard
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assess the Effect of Food on Avanafil Pharmacokinetic (PK), to Compare 2 Oral Formulations of Avanafil,and Investigate Dose Proportionality in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Avanafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Splinting After Mini-Open Carpal Tunnel Release
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: OTHER: No Splint|OTHER: Removable Splint|OTHER: Non-removable Splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerance of Myocardium to Ischemia Injury
Status: COMPLETED
Conditions: Reperfusion Injury|Myocardial Ischemia
Interventions: PROCEDURE: cardiac surgery scheduled in the morning|PROCEDURE: cardiac surgery scheduled in the afternoon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Exploratory Study of KWA-0711 in Patients With Chronic Idiopathic Constipation (CIC)
Status: COMPLETED
Conditions: Chronic Idiopathic Constipation
Interventions: DRUG: KWA-0711|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of AD-35 in Treatment of Subjects With Mild to Moderate Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer Disease, Early Onset
Interventions: DRUG: AD-35 60mg group|DRUG: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sitagliptin/Metformin Fed Bioequivalence Study (0431A-080)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin phosphate/metformin hydrochloride FDC|DRUG: Sitagliptin phosphate|DRUG: Metformin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of a Deaf Child With a Cochlear Implant.
Status: COMPLETED
Conditions: Deafness
Interventions: BEHAVIORAL: Evaluation of the detection of non-linguistic sounds|BEHAVIORAL: Free hearing test categorization|BEHAVIORAL: Early Social Communication Scale (ECSP)|BEHAVIORAL: psychomotor infancy development scale|BEHAVIORAL: NEPSY (two domains: "memory and learning" and "attention and executive functions").
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Two Regimens of Misoprostol Alone for Early Pregnancy Termination and Use of SQPT for At-Home Follow-Up
Status: COMPLETED
Conditions: Pregnancy
Interventions: DRUG: Misoprostol|DEVICE: Semi-quantitative pregnancy test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sildenafil for Treatment of Priapism in Men With Sickle Cell Anemia
Status: COMPLETED
Conditions: Sickle Cell Disease|Priapism
Interventions: DRUG: sildenafil|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Influence of LV5FU2 Bevacizumab Plus Anakinra Association on Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: ANAKINRA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of Single Rising Inhaled Doses of BI 11054 CL Administered With the Respimat® in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 11054 CL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Generic Pimecrolimus Cream, 1% in the Treatment of Mild to Moderate Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Pimecrolimus Cream, 1%|DRUG: Elidel® (pimecrolimus) Cream|DRUG: Placebo of Pimecrolimus Cream, 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transarterial Chemoembolization With Doxorubicin With or Without Everolimus in Treating Patients With Liver Cancer
Status: TERMINATED
Conditions: Liver Cancer
Interventions: DRUG: doxorubicin-eluting beads|DRUG: everolimus|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: OxyPrem Validation Study
Status: TERMINATED
Conditions: Tissue Oxygenation Measurement
Interventions: DEVICE: Measurement of tissue oxygenation with novel diagnostic near-infrared spectroscopy device (OxyPrem) (no clinical decisions based on oxygenation levels)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of Primary Debulking Surgery Versus Neoadjuvant Chemotherapy in Stage IV Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: DRUG: Paclitaxel, Carboplatin|PROCEDURE: debulking surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cheno Effect on Transit in Health and IBS-C
Status: COMPLETED
Conditions: Constipation-predominant Irritable Bowel Syndrome
Interventions: DRUG: Sodium chenodeoxycholate (NaCDC)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Two Formulations of Lisinopril Tablet 20 mg in Healthy Volunteers Under Fasting Conditions
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Lisinopril tablet 20 mg|DRUG: Zestril® tablet 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: ORAL ANTIDIABETICS EFFECT ON VISCERAL FAT
Status: UNKNOWN
Conditions: Abdominal Obesity|Type 2 Diabetes
Interventions: DRUG: Biguanide, DPP4 inhibitors, SGLT2 inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simultaneous Study of Gemcitabine-Docetaxel Combination Adjuvant Treatment, as Well as Extended Bisphosphonate and Surveillance-Trial
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: FEC-DocGemzar adjuvant chemotherapy|DRUG: FEC-Doc adjuvant chemotherapy|DRUG: Zoledronic acid i.v. 2 years|DRUG: Zoledronic acid i.v. 5 years
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PERT for Treatment of Exocrine Pancreatic Insufficiency in Patients With Unresectable Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Insufficiency|Pancreatic Cancer|Pancreatic Enzyme Abnormality
Interventions: DRUG: Pancrelipase|DRUG: Placebo Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Move&Connect: A Program for Youth With Concussion and Their Caregivers.
Status: RECRUITING
Conditions: Post-Concussion Syndrome
Interventions: OTHER: Exercise Circuits|BEHAVIORAL: Goal Setting|BEHAVIORAL: Psychoeducation-Youth|BEHAVIORAL: Psychoeducation-Caregiver|OTHER: Waitlist Control Surveys
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of SK-1405 in Hemodialysis Patients With Uremic Pruritus
Status: COMPLETED
Conditions: Uremic Pruritus in Hemodialysis Patients
Interventions: DRUG: SK-1405 high dose|DRUG: SK-1405 low dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing Visual Feedback of HR Monitoring in Rehabilitation - Pilot
Status: UNKNOWN
Conditions: Exercise Therapy|Heart Rate Determination
Interventions: DEVICE: Heart Rate Recording from Multiple Participants, No visual feedback|DEVICE: Visual Feedback of Multiple Participant Heart Rates
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Randomized Phase II, Open-label Efficacy and Safety Study of Second-line Durvalumab Plus Tremelimumab Versus Platinum-based Chemotherapy Alone in Patients With NSCLC and First-line Checkpoint-inhibitor Therapy (Re-Check)
Status: WITHDRAWN
Conditions: NSCLC Stage IV
Interventions: DRUG: combination regimen tremelimumab /durvalumab|DRUG: platinum-based chemotherapy (SoC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Acute Effects of Capsiate During Exercise
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Acute consumption of Capsiate Natura|DIETARY_SUPPLEMENT: Acute consumption of Capsiate Natura|DIETARY_SUPPLEMENT: Acute ingestion of identical placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Drug Interaction Study With Ribavirin and Abacavir in Male Subjects With Hepatitis C Who Have Failed Ribavirin Treatment
Status: COMPLETED
Conditions: Hepatitis C|HIV
Interventions: DRUG: Ribavirin|DRUG: Ribavirin plus Abacavir (ABC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Extension to Safety and Efficacy of Probuphine in the Treatment of Opioid Dependence
Status: COMPLETED
Conditions: Opioid Dependence
Interventions: DRUG: Probuphine (buprenorphine implant)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Phase II Trial of Surgery Plus Sorafenib vs. Sorafenib Alone for Hepatocellular Cancer (HCC) With Portal Vein Invasion
Status: UNKNOWN
Conditions: Hepatocellular Cancer
Interventions: PROCEDURE: hepatic resection|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Probiotics Added to the Mother's Diet on Preterm Babies
Status: NOT_YET_RECRUITING
Conditions: Preterm|Necrotizing Enterocolitis|Late-Onset Neonatal Sepsis|Breast Milk Expression
Interventions: DIETARY_SUPPLEMENT: Probiotic Product Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D)
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: DRUG: Intralipid|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tivantinib in Treating Patients With Previously Treated Malignant Mesothelioma
Status: TERMINATED
Conditions: Epithelioid Mesothelioma|Recurrent Malignant Mesothelioma|Sarcomatoid Mesothelioma|Stage II Pleural Mesothelioma|Stage III Pleural Mesothelioma|Stage IV Pleural Mesothelioma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Tivantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the BREAST-Q REACT Tool for People Having Breast Surgery
Status: RECRUITING
Conditions: Breast Conserving Surgery|Mastectomy With Reconstruction
Interventions: OTHER: BREAST-Q Physical Well-Being|OTHER: QuickDASH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: S0720: Adjuvant Therapy Based on Gene Expression in Stage IA and IB Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed-Dose Combination (FDC) With and Without Ribavirin for the Treatment of HCV
Status: COMPLETED
Conditions: Chronic Hepatitis C Virus
Interventions: DRUG: LDV/SOF|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Propofol or Sevoflurane on Renal Function
Status: COMPLETED
Conditions: Acute Kidney Injury|Anesthesia
Interventions: PROCEDURE: Back Surgery|DRUG: Propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Whole Body Vibration in Individuals With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: non-random whole body vibration|BEHAVIORAL: occupational therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CAR T Cells Real World Evidence Study Based on the French Hospital Claims Data Source (PMSI)
Status: COMPLETED
Conditions: Diffuse Large B-Cell Lymphoma (DLBCL)|Acute Lymphoblastic Leukemia (ALL)
Interventions: OTHER: KYMRIAH|OTHER: YESCARTA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy Study of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel to Treat Rosacea
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: Clindamycin Phosphate 1.2% And Tretinoin 0.025% Gel|DRUG: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation on the Sustained Effect of Anthocyanins on Endothelial Function in Postmenopausal Women
Status: COMPLETED
Conditions: Post-menopausal Women
Interventions: DIETARY_SUPPLEMENT: Anthocyanin capsules|DIETARY_SUPPLEMENT: placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: CIRCULATING TUMOR DNA BASED DECISION FOR ADJUVANT TREATMENT IN COLON CANCER STAGE II
Status: RECRUITING
Conditions: Patients With Resected Stage II Colon Cancer
Interventions: DRUG: mFOLFOX6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Artificial Intelligence in the Diagnosis of Orthopaedic Conditions, Particularly Bone Tumours and Infection
Status: UNKNOWN
Conditions: Bone Tumours|Bone Infection|Prosthetic Joint Infection|Prosthetic Infection
Interventions: DIAGNOSTIC_TEST: Genomic sequencing|DIAGNOSTIC_TEST: Histological examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: High-Dose Post-Transplant Cyclophosphamide, Bortezomib, and Sitagliptin for the Prevention of GVHD
Status: WITHDRAWN
Conditions: Bone Marrow Transplant Complications|Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia, Adult|Myelodysplastic Syndromes|Chronic Myelomonocytic Leukemia
Interventions: DRUG: Sitagliptin|DRUG: Bortezomib|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Clinical Benefit of SEROQUEL XR in Subjects With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Quetiapine Fumarate Extended- Release
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Posterior Tibial Nerve Electrostimulation With Low Dose Trospium Chloride in OAB in Females
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: COMBINATION_PRODUCT: TPTNS+Drug|DEVICE: TPTNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Early Management Strategies of Acute Heart Failure for Patients With NSTEMI
Status: UNKNOWN
Conditions: Early Management|Acute Heart Failure|NSTEMI - Non-ST Segment Elevation MI
Interventions: DRUG: Regular management+Levosimendan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK Study in Diabetic Transplant récipients : From Twice-daily Tacrolimus to Once-daily Extended-release Tacrolimus
Status: COMPLETED
Conditions: Kidney Transplantation|Pancreas Transplantation|Diabetes
Interventions: DRUG: Tacrolimus and Tacrolimus Extended Release Oral Tablet [Envarsus]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Hemcon© Bandage for Postpartum Bleeding Due to the Multiple Vaginal Lacerations
Status: UNKNOWN
Conditions: Postpartum Bleeding|Vaginal Lacerations|Cervical Lacerations
Interventions: DEVICE: The HemCon GuardaCare|DEVICE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In-office Hysteroscopic Laser Ablation for Symptomatic Submucous Uterine Fibroids
Status: COMPLETED
Conditions: Laser Hysteroscopic Ablation of Submucous Myoma
Interventions: DEVICE: hysteroscopic ablation of submucous uterine fibroid using diode laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of a Questionnaire to Evaluate Patient Expectations for Breast Reconstruction in Women With Breast Cancer or Other Conditions
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BEHAVIORAL: counseling intervention|BEHAVIORAL: questionnaire administration|BEHAVIORAL: psychosocial assessment and care|BEHAVIORAL: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of the Effects of Pericapsular Nerve Group (PENG), Suprainguinal Fascia Iliaca Compartment (S-FICB) and 3-1 Blocks on Comfort in Positioning for Unilateral Spinal Anesthesia and Postoperative Pain in Hip Fracture Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Hip Fractures|Pain Management|Pain Postoperative|Spinal Anesthesia|Nerve Block/Methods
Interventions: PROCEDURE: Pericapsular Nerve Group Block|PROCEDURE: Suprainguinal Fascia Compartment Block|PROCEDURE: 3-1 Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for Stroke
Status: RECRUITING
Conditions: Stroke
Interventions: BIOLOGICAL: AlloRx
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visual Performance Investigation of Two Toric Soft Contact Lenses
Status: COMPLETED
Conditions: Refractive Error|Astigmatism|Myopia|Hyperopia
Interventions: DEVICE: Lotrafilcon B toric contact lens|DEVICE: Comfilcon A toric contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Hydrodissection for Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: PROCEDURE: Ultrasound-guided hydrodissection|PROCEDURE: Placebo ultrasound-guided injection|DEVICE: Ultrasound|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Low Dose Nesiritide With or Without Sildenafil in Congestive Heart Failure Patients With Renal Dysfunction
Status: TERMINATED
Conditions: Congestive Heart Failure|Renal Dysfunction
Interventions: DRUG: low dose Nesiritide|DRUG: nesiritide, Sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: NHS Staff Digital Wellbeing Via AirEmail
Status: RECRUITING
Conditions: Communication Research|Technostress|Work Related Stress|Burnout, Professional|Well-Being, Psychological
Interventions: OTHER: Email use data collection|OTHER: AirEmail Tips and Tricks training|OTHER: AirEmail v1 Digital Tool use
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Dual-light Photodynamic Therapy as an Adjunct to Periodontal Treatment in Smokers
Status: RECRUITING
Conditions: Periodontitis|Dual- Light Photodynamic Therapy|Smoking, Cigarette|Non-surgical Periodontal Therapy
Interventions: DEVICE: Lumoral device, Lumorinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microvascular Dysfunction and the Development of Whole-body Insulin Resistance
Status: COMPLETED
Conditions: Insulin Resistance|Type 2 Diabetes|Obesity
Interventions: DIETARY_SUPPLEMENT: Hypercaloric diet|OTHER: Normocaloric diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective, Open Label, Phase 1 Safety Study of Passive Immune Therapy During Acute Ebola Virus Disease Using Transfusion of INTERCEPT Plasma Prepared From Volunteer Donors Who Have Recovered From Ebola Virus Disease
Status: TERMINATED
Conditions: Acute Ebola Virus Disease
Interventions: BIOLOGICAL: INTERCEPT Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STAAR-2 Clinical Study
Status: COMPLETED
Conditions: Chronic Kidney Disease|Chronic Renal Insufficiency|Kidney Disease|Pre-dialysis|Pre-ESRD
Interventions: DRUG: Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Branched-chain Amino Acid on the Improvement of Serum Albumin Level in Cirrhotic Patients With Ascites
Status: UNKNOWN
Conditions: Cirrhosis|Ascites
Interventions: DRUG: Branched-chain Amino Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Pharmacokinetics of Dinutuximab Beta as Maintenance Therapy in Chinese Patients With High-risk Neuroblastoma
Status: COMPLETED
Conditions: High-risk Neuroblastoma
Interventions: DRUG: Dinutuximab Beta|DRUG: 13 cis retinoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of m-CIMT With and Without Kinesiotaping for Children With Erb's Palsy
Status: RECRUITING
Conditions: Erb Palsy
Interventions: OTHER: m-CIMT without Kinesio taping|OTHER: m-CIMT along with kinesiotaping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comprehensive Multiparametric Magnetic Resonance Imaging After Transurethral Resection of Non Muscle-invasive Bladder Tumor; Can it Replace Second Look Biopsy? A Prospective Study
Status: UNKNOWN
Conditions: Bladder Cancer
Interventions: DEVICE: mpMRI|PROCEDURE: Second look TURBT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of the Group-based Paro Intervention on Physiological and Psychological Outcomes
Status: COMPLETED
Conditions: Dementia, Mild|Dementia Moderate|Cognitive Impairment
Interventions: DEVICE: Paro (social robot) intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Effects of PEEP Levels on Respiratory Mechanics in Patients Undergoing Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Respiratory System Abnormalities
Interventions: PROCEDURE: PEEP 0|PROCEDURE: PEEP 5|PROCEDURE: PEEP 8
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intensive Nutrition in Acute Respiratory Distress Syndrome (ARDS): A Clinical Trial (INTACT)
Status: TERMINATED
Conditions: Acute Lung Injury
Interventions: BEHAVIORAL: intensive medical nutrition|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sublingual Anvirzel in Advance Non-Small Cell Lung Cancer (NSCLC)
Status: WITHDRAWN
Conditions: Chemotherapeutic Agent Toxicity|Lung Cancer
Interventions: DRUG: Carboplatin|DRUG: Docetaxel|DRUG: Anvirzel|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can we Make a VAST Improvement? Promoting Anaesthetists' Non-technical Skills Through the Vital Anaesthesia Simulation Training Course in a Low-resource Setting
Status: COMPLETED
Conditions: To Determine the Change in Demonstrated Anesthesia Non-technical Skills After Delivery of the VAST Course
Interventions: OTHER: VAST Course
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Aflibercept or Bevacizumab as Second-line Treatment of RAS Mutated Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Folfiri/Bevacizumab|DRUG: Folfiri/Aflibercept
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dapagliflozin in Type 2 Diabetes Mellitus Patients (T2DM) With Nonalcoholic Fatty Liver Disease (NAFLD)
Status: RECRUITING
Conditions: Nonalcoholic Fatty Liver Disease|Type 2 Diabetes
Interventions: DRUG: Dapagliflozin 10mg Tab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Technical Skills Training in Undergraduate Nursing Students: SimCapture for Skills.
Status: COMPLETED
Conditions: Education, Nursing Students
Interventions: OTHER: Simcapture PRE|OTHER: Simcapture POST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Low-dose Interleukin-2 for the Reduction of Vascular Inflammation in Acute Coronary Syndromes - IVORY
Status: COMPLETED
Conditions: Acute Coronary Syndromes
Interventions: DRUG: Interleukin-2 [IL-2]|OTHER: Placebo Dextrose 5% solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient-Centered Tablets: Applications for Inpatient Admissions
Status: COMPLETED
Conditions: Mobile Health
Interventions: OTHER: Extensive bedside training for accessing patient portal|OTHER: Limited bedside training on patient portal use.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neurogenic Lower Urinary Tract Symptoms in Patients With Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis|Neurogenic Bladder
Interventions: DIAGNOSTIC_TEST: Urodynamic Study (Filling cystometry and pressure-flow study)|DIAGNOSTIC_TEST: Questionnaires|DIAGNOSTIC_TEST: Uroflowmetry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enteral Naloxone Versus a Traditional Bowel Regimen for the Prevention of Opioid Induced Constipation in Trauma Patients
Status: TERMINATED
Conditions: Constipation|Analgesia
Interventions: DRUG: Naloxone and Docusate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Randomized Trial Comparing Endoscopy and Surgery for Pancreatic Cyst-gastrostomy
Status: COMPLETED
Conditions: Pancreatic Pseudocysts
Interventions: PROCEDURE: Endoscopic cyst-gastrostomy|PROCEDURE: Surgical cyst-gastrostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Tafenoquine (TQ) Co-administered With Dihydroartemisinin-piperaquine (DHA-PQP) for the Radical Cure of Plasmodium Vivax (P. Vivax) Malaria
Status: COMPLETED
Conditions: Malaria, Vivax
Interventions: DRUG: Tafenoquine|DRUG: Matched-Placebo for Tafenoquine|DRUG: Primaquine|DRUG: Matched-Placebo for Primaquine|DRUG: Dihydroartemisinin-piperaquine (DHA-PQP)|DRUG: ACT plus PQ (Rescue medication)|DRUG: PQ (End of study treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Felzartamab in Healthy Adult Subjects
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: T|DRUG: R
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Animal Intervention Used as Therapy
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: BEHAVIORAL: AAT and cognitive stimulation and rehabilitation of social tie.|BEHAVIORAL: Cognitive stimulation and rehabilitation of social tie.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: School Influenza Vaccine vs Standard of Care With Nested Trial of 2 Parent Notification Intensities
Status: COMPLETED
Conditions: Immunizations|Vaccination|Influenza|School Health
Interventions: BEHAVIORAL: School based flu vaccine: Low intensity|BEHAVIORAL: School based flu vaccine: High intensity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Contrast (Sonazoid)-Enhanced US as a Screening Tool for Hepatocellular Carcinoma in Cirrhosis: An Exploratory Cross-sectional Study
Status: COMPLETED
Conditions: Hepatocellular Carcinoma (HCC)
Interventions: OTHER: Sonazoid-enhanced ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Vildagliptin Versus Liraglutide - Patient Preference After Receiving Both Medications
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Vildagliptin/ Metformin|DRUG: Liraglutide|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Substitution of Darunavir/Ritonavir (DRV/r) for Dual-boosted Protease Inhibitors
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Darunavir (DRV/r)|DRUG: continue on current dual boosted PI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pegylated Recombinant Human Granulocyte Stimulating Factor in Secondary Prevention of Albumin Paclitaxel Combined With S-1 in the First-line Treatment of Advanced Pancreatic Cancer
Status: UNKNOWN
Conditions: Advanced Pancreatic Cancer
Interventions: DRUG: PEG-rhG-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Impact of Treating Minor Uterine Cavity Abnormalities Diagnosed by Office Hysteroscopy in Unselected In Vitro Fertilization (IVF) Cases
Status: TERMINATED
Conditions: Minor Intra-uterine Abnormalities
Interventions: PROCEDURE: Treatment of predefined abnormality by hysteroscopic surgery|DRUG: Ofloxacinum/Doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Seneca Valley Virus-001 After Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: Seneca Valley virus-001|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aumolertinib With Chemotherapy or Alone Compared With Osimertinib in Patients With Epidermal Growth Factor Receptor-Mutant Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: NSCLC
Interventions: DRUG: Aumolertinib monotherapy|DRUG: Osimertinib monotherapy|DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Nab paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proteinuria in Renal Transplant Patients Treated With Dapagliflozin
Status: RECRUITING
Conditions: Chronic Kidney Diseases
Interventions: PROCEDURE: Follow-up at D14|PROCEDURE: Follow-up at M1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effect of Breastmilk for Procedural Pain in Preterm Infants
Status: UNKNOWN
Conditions: Procedural Pain
Interventions: OTHER: Breastmilk|OTHER: Oral Sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dasatinib or Placebo, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: dasatinib|DRUG: temozolomide|OTHER: placebo|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rotational Thromboelastometry Versus Conventional Haemostatic Tests in Children With Decompensated Cirrhosis Undergoing Invasive Procedures.
Status: RECRUITING
Conditions: Decompensated Cirrhosis
Interventions: DIAGNOSTIC_TEST: ROTEM Tests|DIAGNOSTIC_TEST: Conventional Haemostatic Tests
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Nutritional Intervention for Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Vegan Diet|DIETARY_SUPPLEMENT: dietary supplement omega3 fatty acids aand vitamins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CIRCumcision and Urinary Tract Infections in Boys With Posterior Urethral Valves
Status: COMPLETED
Conditions: Posterior Urethral Valves
Interventions: PROCEDURE: Circumcision|OTHER: Antibiotic prophylaxis alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chidamide, Azacitidine Combined With GM Regimen for Relapsed and Refractory DLBCL Patients
Status: RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Chidamide|DRUG: Azacitidine|BIOLOGICAL: obinutuzumab|DRUG: Liposomal mitoxantrone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ASP0739 Alone and With Pembrolizumab in Advanced Solid Tumors With NY-ESO-1 Expression Participants
Status: TERMINATED
Conditions: Ovarian Cancer|NSCLC|ESCC|Solid Tumors
Interventions: DRUG: ASP0739
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pediatric Comparison of Remote Microphone Technologies
Status: ENROLLING_BY_INVITATION
Conditions: Hearing Loss
Interventions: DEVICE: Phonak Roger TouchScreen Microphone|DEVICE: Phonak Partner Mic
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of Epileptic Motor Patterns by Tridimensional Analysis of Movement 2
Status: TERMINATED
Conditions: Epileptic Patients With Motor Manifestations During Seizures
Interventions: DEVICE: 3-D accelerometric and magnetic sensors
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Stratified, Multi-ARm, muLti-site Randomised Platform Trial Aiming to Reduce the INcidence of Post-operative SSI
Status: NOT_YET_RECRUITING
Conditions: Surgical Site Infection
Interventions: OTHER: Chlorhexidine Gluconate 2.0% to 4.0% (e.g. Hibiscrub) preoperative shower|OTHER: Intraoperative wound wash (e.g. Granudacyn)|OTHER: DACC surgical wound dressing (e.g. Leukomed Sorbact)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Low-intensity Versus Medium-intensity Continuous Kidney Replacement Therapy for Critically Ill Patients
Status: RECRUITING
Conditions: Acute Kidney Injury Requiring Continuous Renal Replacement Therapy
Interventions: DRUG: Dialysate fluid, Filtration replacement fluid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Outcomes of Lumbar Epidural Steroid Injections for Spinal Stenosis
Status: COMPLETED
Conditions: Lumbar Spinal Stenosis
Interventions: OTHER: Individualized report
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Microdialysis and Pharmacokinetic Study of TR-701
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: TR-700 (active moiety)|DRUG: TR-701 (pro-drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE