pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Dutasteride for Improving Peri-Operative and Long-Term Outcomes of Photoselective Vaporization of the Prostate (DOP)
Status: UNKNOWN
Conditions: Benign Prostatic Hyperplasia|Lower Urinary Tract Symptoms
Interventions: DRUG: dutasteride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation Of Bacillus Clausii In Treatment Of Acute Diarrhea In Latin American Children
Status: COMPLETED
Conditions: Acute Gastroenteritis
Interventions: DRUG: Bacillus clausii|DRUG: Oral Rehydration Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Efficacy of Acamprosate and Calcium in Comparison to Placebo as Validation of a Behavioural Test for Alcohol Dependence
Status: COMPLETED
Conditions: Alcoholism
Interventions: DRUG: Acamprosate Calcium|DRUG: Calcium Carbonate|DRUG: Placebo|DRUG: Placebo lead in
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial Comparing Split-Dose Miralax With Amitiza Pretreatment Versus Dulcolax Pretreatment Versus Golytely for Bowel Cleansing Prior to Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: Miralax (PEG 3350)|DRUG: Amitiza (Lubiprostone)|DRUG: Dulcolax (Bisacodyl)|DRUG: Golytely (polyethylene glycol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab in Treating Patients With Advanced Metastatic Non-small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Recurrent Non-Small Cell Lung Carcinoma|Stage IV Non-Small Cell Lung Cancer
Interventions: BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension Study of Cinacalcet for Treatment of Secondary Hyperparathyroidism (SHPT) in Pediatric Patients With Chronic Kidney Disease on Dialysis
Status: COMPLETED
Conditions: Secondary Hyperparathyroidism, Chronic Kidney Disease
Interventions: DRUG: Cinacalcet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vestibular and Postural Function in an Unselected Group of Children With Sensorineural Hearing Loss
Status: NOT_YET_RECRUITING
Conditions: Children, Only|Vestibular Disorder|Vestibular Function|Sensorineural Hearing Loss
Interventions: DIAGNOSTIC_TEST: video Head Impulse Test|DIAGNOSTIC_TEST: Cervical Vestibular Evoked Myogenic Potential|DIAGNOSTIC_TEST: Ocular Vestibular Evoked Myogenic Potential|DIAGNOSTIC_TEST: Computerized Dynamic Posturography|OTHER: Dizziness Handicap Inventory for patient caregivers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TMC649128HPC1002 - a Trial inGenotype 1 Hepatitis C Virus (HCV) - Infected Participants to Determine the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of TMC649128, Alone and Combined With Pegylated Interferon + Ribavirin
Status: TERMINATED
Conditions: Hepatitis C Virus
Interventions: DRUG: placebo.|DRUG: placebo.|DRUG: TMC649128.|DRUG: placebo.|DRUG: placebo|DRUG: TMC649128|DRUG: TMC649128.|DRUG: TMC649128|DRUG: TMC649128.|DRUG: placebo.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Nicotine and Attention on Frequency Tuning in Auditory Cortex
Status: RECRUITING
Conditions: Aging
Interventions: DRUG: Nicotine gum|OTHER: Placebo gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hypothermic Oxygenated Machine Perfusion of Extended Criteria Kidney Allografts From Brain Death Donors
Status: COMPLETED
Conditions: Reperfusion Injury|Hypothermic Oxygenated Machine Perfusion
Interventions: PROCEDURE: HOPE|OTHER: Conventional cold storage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zandelisib + Tazemetostat in R/R Follicular Lymphoma
Status: WITHDRAWN
Conditions: Relapsed Follicular Lymphoma|Refractory Follicular Lymphoma
Interventions: DRUG: TAZEMETOSTAT|DRUG: Zandelisib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Administration of Tadalafil in Conjunction With Lenalidomide and Dexamethasone in Patients With Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Tadalafil|DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lipid Efficacy Study (0524B-022)(COMPLETED)
Status: COMPLETED
Conditions: Primary Hypercholesterolemia|Mixed Hyperlipidemia
Interventions: DRUG: niacin (+) laropiprant (+) simvastatin|DRUG: Comparator: niacin (+) laropiprant|DRUG: Comparator: simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Motivational Interviewing Compared to Psychoeducation for Smoking Precontemplators With SMI
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: OTHER: Motivational Interviewing|OTHER: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Upper Vaginectomy Versus Brachytherapy in Patients With Early Stage Endometrial Cancer Treated With Laparoscopic Surgery
Status: UNKNOWN
Conditions: Early Stage Endometrial Cancer
Interventions: PROCEDURE: Upper vaginectomy|RADIATION: Post-operative brachytherapy|PROCEDURE: Standard procedures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Factors Mediating the Relationship Between Childhood Trauma and Auditory Hallucinations in Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: OTHER: Self-questionnaires battery|OTHER: Socio-demographic screening
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD)
Status: RECRUITING
Conditions: Huntington Disease
Interventions: DRUG: PTC518|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mino-Lok Therapy (MLT) for the Treatment of CRBSI/CLABSI
Status: UNKNOWN
Conditions: Catheter-related Infections
Interventions: DRUG: Mino-Lok|DRUG: Antibiotic lock
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optical Spectroscopy in Evaluating Tumor Margins in Patients Who Have Undergone Surgery for Breast Tumors
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: breast biopsy|PROCEDURE: histopathologic examination|PROCEDURE: light-scattering spectroscopy|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Comparison of Eleview Versus Hetastarch as Injectate for EMR
Status: COMPLETED
Conditions: Procedural Bleeding|Delayed Bleeding|Post-Polypectomy Syndrome|Post Procedural Complication
Interventions: DRUG: Eleview|DRUG: Hetastarch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Saracatinib in Treating Patients With Previously Treated Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer
Interventions: DRUG: saracatinib|OTHER: pharmacogenomic studies|OTHER: pharmacological study|PROCEDURE: positron emission tomography|RADIATION: fludeoxyglucose F 18|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reversal of Botulinum Neurotoxin Injection Related Dysphonia With Pyridostigmine
Status: UNKNOWN
Conditions: Dysphonia, Spastic|Dysphonia|Laryngeal Dystonia
Interventions: DRUG: Pyridostigmine Bromide 60 Milligrams (mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Acetyl-L-carnitine in Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Acetyl-L-carnitine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Emerging From the Haze™- Measuring the Impact of a Psycho-education Program on Perceived Cognition After Breast Cancer Treatment
Status: COMPLETED
Conditions: Cognition|Cancer
Interventions: OTHER: Emerging from the Haze
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: S0122: Combination Chemotherapy, Radiation Therapy, and Vaccine Therapy in Limited-Stage Small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: monoclonal antibody 11D10 anti-idiotype vaccine|BIOLOGICAL: monoclonal antibody GD2 anti-idiotype vaccine|DRUG: cisplatin|DRUG: etoposide|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Patients With Stage III or Stage IV Prostate Cancer
Status: WITHDRAWN
Conditions: Adenocarcinoma of the Prostate|Stage III Prostate Cancer|Stage IV Prostate Cancer|Recurrent Prostate Cancer
Interventions: DRUG: antineoplaston A10|DRUG: antineoplaston AS2-1|DRUG: bicalutamide|DRUG: flutamide|DRUG: leuprolide acetate|PROCEDURE: alternative product therapy|PROCEDURE: antiandrogen therapy|PROCEDURE: biological therapy|PROCEDURE: biologically based therapies|PROCEDURE: cancer prevention intervention|PROCEDURE: complementary and alternative therapy|PROCEDURE: differentiation therapy|PROCEDURE: endocrine therapy|PROCEDURE: hormone therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Gastrointestinal (GI) Safety and Tolerability of Aliskiren Compared to Ramipril in Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Aliskiren|DRUG: Ramipril|OTHER: Placebo to Ramipril|OTHER: Placebo to Aliskiren
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Extension Study of 1 mg/kg Pegunigalsidase Alfa Every 2 Weeks in Patients With Fabry Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Fabry Disease
Interventions: DRUG: pegunigalsidase alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Panobinostat in Combination With Everolimus for Children and Young Adults With Gliomas
Status: WITHDRAWN
Conditions: Glioma|Diffuse Intrinsic Pontine Glioma
Interventions: DRUG: Panobinostat|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Multi-Center Study of Short-Term Outcomes After Complex Cholecystectomy
Status: RECRUITING
Conditions: Laparoscopic Cholecystectomy|Robotic-assisted Cholecystectomy
Interventions: PROCEDURE: Laparoscopic cholecystectomy|PROCEDURE: Robotic-assisted cholecystectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Expanded UCMSCs On Patients With Moderate to Severe Psoriasis
Status: UNKNOWN
Conditions: Mesenchymal Stromal Cells|Psoriasis|Drug Effect|Drug Toxicity
Interventions: BIOLOGICAL: Umbilical cord mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Synthetic Bone Substitute and a Bovine-derived Xenograft in Horizontal Bone Augmentation
Status: COMPLETED
Conditions: Jaw, Edentulous|Jaw, Edentulous, Partially
Interventions: DEVICE: Straumann BoneCeramic|DEVICE: Bio-Oss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Collared Versus Collarless Femoral Implants for Total Hip Arthroplasty
Status: COMPLETED
Conditions: Hip Osteoarthritis|Hip Arthroplasty
Interventions: DEVICE: Collared Femoral Implant|DEVICE: Collarless Femoral Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Cirmtuzumab and Paclitaxel for Metastatic or Locally Advanced, Unresectable Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Cirmtuzumab + Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pelvic Muscle Training and Electrostimulation to Treat Weak Pelvic Floor
Status: RECRUITING
Conditions: Pelvic Floor Muscle Weakness|Incontinence Stress|Electricity; Effects|Muscle Weakness Condition
Interventions: DEVICE: EMG-triggered ES|OTHER: Pelvic Floor Muscle Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Implementing a Blended Care Model That Integrates Mental Healthcare and Primary Care Using Telemedicine and Care Management for Patients With Depression or Alcohol Use Disorder in Small Primary Care Clinics
Status: COMPLETED
Conditions: Depressive Disorders|Alcohol Use Disorders|Post-traumatic Stress Disorder (PTSD)
Interventions: OTHER: Usual Care|OTHER: Blended Telemedicine-Based Integrated Care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clonidine as Adjunct to Morphine for Neonatal Abstinence Syndrome
Status: TERMINATED
Conditions: Neonatal Abstinence Syndrome
Interventions: DRUG: Clonidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The prEgnanCy and eArly Childhood nutrItion triaL (ECAIL)
Status: RECRUITING
Conditions: Diet|Growth|Infant|Physical Activity|Sedentary Behavior
Interventions: BEHAVIORAL: Experimental: Intervention Program|BEHAVIORAL: Active comparator: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Phase II Study About Combination CHOP-21, Obinutuzumab and Ibrutinib in Untreated Young High Risk DLBCL Patients.
Status: TERMINATED
Conditions: Lymphoma, B-Cell
Interventions: DRUG: Obinutuzumab|DRUG: Ibrutinib|DRUG: CHOP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DISCERN: Dual Versus Single ICB in PDL-1 Negative NSCLC
Status: NOT_YET_RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Pemetrexed|DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Open Study, Prospective, Multicenter, Randomized, Comparative to the Positive Control for Evaluating the Efficacy and Safety of Auris-Sedina in the Symptomatic Control of Otalgy in Patients With or Without Acute External Otitis.
Status: UNKNOWN
Conditions: Otitis|Efficacy|Tolerability
Interventions: DRUG: Auris-Sedina|DRUG: Otosynalar®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liraglutide in Newly Onset Type 1 Diabetes.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Liraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Malaria Therapeutic Efficacy Study, Rwanda
Status: COMPLETED
Conditions: Uncomplicated Malaria
Interventions: DRUG: artemether-lumefantrine (ALN)|DRUG: dihydroartemisinin-piperaquine (DHA-PPQ)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Failed Carpal Tunnel Syndrome by Dorsal Ulnar Artery Perforator Adipofascial Flap
Status: RECRUITING
Conditions: Failed Carpal Tunnel Syndrome Surgery
Interventions: PROCEDURE: Treatment of failed carpal tunnel syndrome by dorsal ulnar artery perforator adipofascial flap
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Food on the Oral Bioavailability of AEF0117 in Healthy Volunteers
Status: TERMINATED
Conditions: Marijuana Abuse
Interventions: DRUG: 3ß-(4-methoxybenzyloxy)pregn-5-en-20-one in fed condition|DRUG: 3ß-(4-methoxybenzyloxy)pregn-5-en-20-one in fasting condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Remnant Preserving Versus Remnant Resecting Anterior Cruciate Ligament Reconstruction
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Rupture
Interventions: PROCEDURE: anterior cruciate ligament reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Enhancing Educational and Vocational Recovery in Adolescents and Young Adults With Early Psychosis Through Supported Employment and Education.
Status: RECRUITING
Conditions: Persistent Delusional Disorder|Acute and Transient Psychotic Disorder, Unspecified|Schizophrenia|Schizoaffective Disorder|Other Nonorganic Psychotic Disorders|Unspecified Nonorganic Psychosis
Interventions: OTHER: Individual Placement and Support (IPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Camrelizumab Combined With Apatinib Mesylate for Head and Neck Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Camrelizumab|DRUG: Apatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mental Health and Aggression in Congolese Ex-combatants
Status: COMPLETED
Conditions: Appetitive Aggression|Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: A variant of Narrative Exposure Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemoembolization for Lung Tumors
Status: COMPLETED
Conditions: Lung Metastases|Endobronchial Metastases|Pleural Metastases|Mediastinal Metastases
Interventions: PROCEDURE: Chemoembolization|DRUG: Mitomycin C|DRUG: Lipiodol|DRUG: Embospheres
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Discontinuation of Maintenance Corticosteroid Treatment in Quiescent Systemic Lupus
Status: UNKNOWN
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: prednisone discontinuation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension Study of Eculizumab in Patients With Transfusion Dependent Paroxysmal Nocturnal Hemoglobinuria (PNH)
Status: COMPLETED
Conditions: Paroxysmal Hemoglobinuria, Nocturnal
Interventions: DRUG: eculizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Cetuximab in Combination With 5-fluoruracil, Mitomycin C and Radiotherapy in Patients With Anal Cancer Stage T2 (>4 cm) - T4 N0-3 M0 or Any T N2-3 M0
Status: COMPLETED
Conditions: Locally Advanced Cancer in the Anal Region
Interventions: DRUG: Cetuximab|DRUG: Mitomycin C|DRUG: 5-Fluoruracil|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remimazolam for Cataract Surgery
Status: NOT_YET_RECRUITING
Conditions: Cataract Surgery|Cognitive Impairment
Interventions: DRUG: Remimazolam|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial in Parkinson's Disease Patients Using Pluripotent Adipose Stem Cells (PASCs)
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson Disease
Interventions: BIOLOGICAL: PASC transplantation (25 million PASCs/patient)|BIOLOGICAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fludarabine-based Conditioning for Severe Aplastic Anemia (BMT CTN 0301)
Status: COMPLETED
Conditions: Anemia, Aplastic
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide 150mg|DRUG: Cyclophosphamide 100mg|DRUG: Cyclophosphamide 50mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crossover Study to Assess the Efficacy and Safety of UX007 in the Treatment of Movement Disorders Associated With Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS)
Status: TERMINATED
Conditions: Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS)
Interventions: DRUG: UX007|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transition to Adulthood Through Coaching and Empowerment
Status: RECRUITING
Conditions: Juvenile Idiopathic Arthritis|Inflammatory Bowel Diseases
Interventions: BEHAVIORAL: Transition Coach Intervention|BEHAVIORAL: Standard of Care- Youth Transition Roadmap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Single and Multiple Dose Escalation Trial of an Intravenous Antibiotic RC-01
Status: TERMINATED
Conditions: Safety
Interventions: DRUG: Single intravenous doses of RC-01|DRUG: Single intravenous doses of placebo|DRUG: Multiple intravenous doses of RC-01|DRUG: Multiple intravenous doses of placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Idarubicin, Cytarabine, and Vorinostat With High-Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome (MDS)
Interventions: DRUG: Idarubicin|DRUG: Cytarabine|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In-Person Lifestyle Program for Black Adolescent Girls at Risk for Type 2 Diabetes
Status: RECRUITING
Conditions: Behavior, Adolescent|Childhood Obesity|Diabetes Mellitus, Type 2|Pediatric Obesity|Glucose Metabolism Disorders|Metabolic Disease|Endocrine System Diseases|Overweight|Overnutrition|Nutrition Disorders|Body Weight|Diabetes Mellitus
Interventions: BEHAVIORAL: Black Girls for Wellness In-Person
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sunitinib to Treat Recurrent Brain Cancer
Status: TERMINATED
Conditions: Glioblastoma Multiforme|Malignant Gliomas|Anaplastic Gliomas
Interventions: DRUG: Sutent (sunitinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rotator Cuff Augmentation With Human Dermal Allograft Versus Bovine Collagen Xenograft Patch: A Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Rotator Cuff Tears
Interventions: PROCEDURE: Rotator cuff repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study to Assess Safety & Immunogenicity of Multimeric-001 Influenza Vaccine, Followed by TIV
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: M-001|DRUG: TIV|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Islet of Langerhans Graft Monitoring by Magnetic Resonance Imaging
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: ferucarbotran (iron-based MRI contrast agent)|PROCEDURE: Islet transplantation|PROCEDURE: Magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Efficacy and Safety of Pirfenidone in Patients With Fibrotic Hypersensitivity Pneumonitis
Status: TERMINATED
Conditions: Interstitial Lung Disease
Interventions: DRUG: Pirfenidone|OTHER: Placebo controlled
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise Training After Transcatheter Aortic Valve Implantation
Status: COMPLETED
Conditions: Aortic Valve Stenosis|TAVI|Transcatheter Aortic Valve Implantation|Rehabilitation
Interventions: OTHER: Exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Orelabrutinib Combined With R-CDOP for DLBCL Patients With High-risk of CNS Relapse Defined by CNS-IPI
Status: RECRUITING
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: Orelabrutinib combined with R-CDOP regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xarelto on Prevention of Stroke and Non-central Nervous System Systemic Embolism in Patients With Non-valvular Atrial Fibrillation in China: A Non-interventional Study
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: Rivaroxaban (Xarelto, BAY 59-7939)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase I Study of the Safety, Distribution, and Radiation Dosimetry of Ultratrace Iobenguane 123I-mIBG
Status: COMPLETED
Conditions: Neuroendocrine Tumors|Heart Failure
Interventions: DRUG: no carrier added metaiodobenzylguanidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pilot Study to Characterize and Examine the Pharmacokinetics and Efficacy of Chronocort® in Adults With CAH
Status: COMPLETED
Conditions: Endocrine Disease|Adrenal Insufficiency|Congenital Adrenal Hyperplasia
Interventions: DRUG: Hydrocortisone Modified Release Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasonograpahic Evaluation of Diaphragmatic Functions in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy
Status: COMPLETED
Conditions: Bariatric Surgery Candidate
Interventions: PROCEDURE: addition of positive end expiratory pressure in ventilated patients|PROCEDURE: addition of positive end expiratory pressure and recruitment maneuver in ventilated patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Research on Oral Tolerability and Product Application/Response of Two Oxalate Products for Dental Patients With Risk of Dentinal Hypersensitivity
Status: COMPLETED
Conditions: Dentinal Hypersensitivity
Interventions: DEVICE: Potassium Oxalate Gel|DEVICE: Potassium Oxalate Liquid|DRUG: Stannous fluoride paste
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Statin Therapy to Improve Medication Adherence
Status: COMPLETED
Conditions: Hypercholesterolemia|HMG COA Reductase Inhibitor Adverse Reaction
Interventions: GENETIC: Genetic testing and reporting for SLCO1B1*5 allele
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Non-invasive Vagus Nerve Stimulation (nVNS) in Pediatric Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Status: TERMINATED
Conditions: Chronic Inflammatory Demyelinating Polyneuropathy
Interventions: DEVICE: Non-invasive vagus nerve stimulation (nVNS)|OTHER: Standard of care treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Gingival Flap Procedure Using Conventional Surgical Loupes vs. Videoscope for Visualization
Status: ENROLLING_BY_INVITATION
Conditions: Periodontal Diseases|Periodontal Pocket|Periodontitis|Periodontal Inflammation|Periodontal Attachment Loss|Periodontal Bone Loss|Surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ME-344 in Early HER2-negative Breast Cancer With Antiangiogenic-induced Mitochondrial Metabolism
Status: COMPLETED
Conditions: Breast Cancer|Human Epidermal Growth Factor 2 Negative Carcinoma of Breast|Early-Stage Breast Carcinoma
Interventions: DRUG: ME-344|DRUG: Bevacizumab|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long-term Extension Study of MCI-196
Status: TERMINATED
Conditions: Chronic Kidney Disease|Dialysis|Hyperphosphatemia|Paediatric
Interventions: DRUG: colestilan|DRUG: CBPB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of SAGE-547 in Participants With Moderate Postpartum Depression (547-PPD-202C)
Status: COMPLETED
Conditions: Postpartum Depression
Interventions: DRUG: Placebo|DRUG: SAGE-547 90 μg/kg/h
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment Outcomes For Functional Dyspepsia Based On Current International Guidelines In Multi-Ethnic Asian Patients
Status: RECRUITING
Conditions: Functional Dyspepsia
Interventions: DRUG: Treatment based on subtypes: Esomeprazole or Itopride|DRUG: Treatment with proton pump inhibitor regardless of subtype: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous T3011 Given as a Single Agent and in Combination With Other Therapy in Subjects With Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor|Hepatocellular Carcinoma|Colorectal Cancer|NSCLC|Ovarian Cancer|Endometrial Cancer
Interventions: BIOLOGICAL: T3011
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose-escalating Clinical Trial With KH176
Status: COMPLETED
Conditions: MELAS|LHON|Leigh Syndrome|Mitochondrial Disease|Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation
Interventions: DRUG: KH176|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Granisetron 1 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Granisetron hydrochloride 1 mg tablets|DRUG: Kytril® 1 mg tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prospective Multicenter Cohort Study to Validate Four Groups of Biomarkers for Assessing Lung Cancer Risk Among Patients With Atheromatous Cardiovascular Disease in a Screening Pathway
Status: RECRUITING
Conditions: Smoking-related Pathology|Atheroma|Non-progressive Cancer > 5 Years|Lung Cancer
Interventions: DIAGNOSTIC_TEST: blood sampling|DIAGNOSTIC_TEST: stool collection|RADIATION: low dose CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Preventing Catheter-Associated Urinary Tract Infections With a Virtual Simulation Game
Status: COMPLETED
Conditions: Catheter-Associated Urinary Tract Infection|Nurse's Role
Interventions: OTHER: Virtual Simulation Game for the Prevention of Catheter-Associated Urinary Tract Infections|OTHER: Ongoing education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Cryotherapy Combined With Intralesional Tuberculin PPD Versus Intralesional Tuberculin PPD in Treatment of Multiple Common Warts
Status: UNKNOWN
Conditions: Common Wart
Interventions: BIOLOGICAL: Tuberculin purified protein derivative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of the Probiotic Visbiome Extra Strength on Gut Microbiome & Immune Activation Markers
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Visbiome Extra Strength|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of Oral Uremic Toxin Absorbent and Probiotics to Retard the Progression of Chronic Kidney Disease
Status: RECRUITING
Conditions: CKD
Interventions: DIETARY_SUPPLEMENT: Active bamboo charcoal|DIETARY_SUPPLEMENT: Probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Biomarkers in the Diagnosis and Prognosis of NAFLD
Status: RECRUITING
Conditions: NAFLD|Obesity|Liver Fibrosis|Diabetes Mellitus, Type 2
Interventions: DIAGNOSTIC_TEST: Plasma Test|DIAGNOSTIC_TEST: Plasma test|DIAGNOSTIC_TEST: Plasma test|DIAGNOSTIC_TEST: Plasma test|DIAGNOSTIC_TEST: Liver biopsy|DIAGNOSTIC_TEST: Visceral adipose tissue biopsy|DIAGNOSTIC_TEST: Liver elastography|DIAGNOSTIC_TEST: Blood test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized, Placebo Controlled Study to Determine the Efficacy and Speed of a Nasal Spray in Allergen Induced Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Azelastine and placebo|DRUG: Loratadine and Placebo|DRUG: Cetirizine and Placebo|DRUG: Placebo and Placebo (spray and Tablet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Exogenous Ketones on Glucose Tolerance
Status: COMPLETED
Conditions: Dietary Supplement: Ketone Supplement|Dietary Supplement: Placebo
Interventions: DIETARY_SUPPLEMENT: Ketone monoester|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparative Effectiveness Trial in the Treatment of Pediatric Plaque Morphea
Status: WITHDRAWN
Conditions: Scleroderma
Interventions: DRUG: Clobetasol|DRUG: Calcipotriene|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary and Ventilatory Effects of Trigger Modulation in Intubated ICU
Status: COMPLETED
Conditions: ICU Patients|Intubation|Spontaneously Breathing|Pulmonary Function|Tracheotomy
Interventions: OTHER: Trigger setting of pressure support ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Intrapartum Antibiotics and Immunological Markers for Postpartum Morbidity in HIV Positive Women
Status: COMPLETED
Conditions: Puerperal Sepsis
Interventions: DRUG: Intrapartum Cefoxitin (2g) vs. placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Effect Of Calcitriol On Neutrophil To Lymphocytes Ratio And High Sensitivity C-Reactive Protein Covid-19 Patients
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Calcitriol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetoencephalography by Optical Pumping Magnetometer
Status: RECRUITING
Conditions: Magnetoencephalography|Optical Pump Magnetometer|Neonate|Premature
Interventions: OTHER: Magnetoencephalography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Prospective Multicenter Randomized and Controlled Study Evaluating the Benefit of Early Pulmonary Vein Isolation Compared to Usual Treatment in Patients Aged Over 75 Years and Presenting With Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Rhythm control by Pulmonary Vein Isolation (PVI) procedure|DRUG: Conventional care by antiarrhythmic drugs (flecainide, sotalol, amiodarone) or bradycardic drugs (all betablocker or calcium channel blocker therapy, digoxin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 68-Ga PSMA 11 PET/MRI and 68-Ga RM2 PET/MRI for Evaluation of Prostate Cancer Response to HIFU Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: 68-Ga RM2|DRUG: 68-Ga PSMA11|DEVICE: Investigational software and coils in PET/MR Scan|PROCEDURE: PET/MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of an Anti-cancer Drug, Hu5F9-G4 (Magrolimab), to the Usual Chemotherapy Treatment (Mogamulizumab) in T-Cell (a Type of Immune Cell) Lymphoma That Has Returned After Treatment or Does Not Respond to Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Mycosis Fungoides|Recurrent Mycosis Fungoides|Recurrent Mycosis Fungoides and Sezary Syndrome|Recurrent Sezary Syndrome|Refractory Mycosis Fungoides|Refractory Mycosis Fungoides and Sezary Syndrome|Refractory Sezary Syndrome|Sezary Syndrome|Stage IB Mycosis Fungoides and Sezary Syndrome AJCC v8|Stage II Mycosis Fungoides and Sezary Syndrome AJCC v8|Stage III Mycosis Fungoides and Sezary Syndrome AJCC v8|Stage IV Mycosis Fungoides and Sezary Syndrome AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|BIOLOGICAL: Magrolimab|BIOLOGICAL: Mogamulizumab|PROCEDURE: Positron Emission Tomography|PROCEDURE: Punch Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Multiple Oral Doses of PF-06835919 in Healthy Adult Japanese Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06835919|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Controlled Trial to Assess Blockade of Voltage Gated Sodium Channels During Surgery in Operable Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Operable Breast Cancer
Interventions: DRUG: 0.5% lignocaine 60mM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nonvisual Foot Inspection for People With Visual Imapirment
Status: COMPLETED
Conditions: Diabetes|Visual Impairment
Interventions: BEHAVIORAL: Nonvisual foot inspection|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Intermittent ADVOS vs. Hemodialysis in Non-intensive Care Patients With Liver Dysfunction
Status: RECRUITING
Conditions: Liver Cirrhosis|Kidney Failure, Acute|Kidney Replacement|Multi Organ Failure
Interventions: DEVICE: Hemodialysis|DEVICE: ADVOS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Interaction of Padsevonil With Oral Contraceptives in Healthy Female Participants
Status: TERMINATED
Conditions: Healthy Female Participants
Interventions: DRUG: Padsevonil|DRUG: Microgynon 30®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Safety and Effectiveness of the Kinamed Gem Ceramic Femoral Component for Total Knee Replacement
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: zirconia femoral component|DEVICE: cobalt chrome femoral component
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ombitasvir/ABT-450 (Paritaprevir)/Ritonavir With Dasabuvir and Ribavirin (RBV) in Treatment Naive and Treatment Experienced Genotype 1a Hepatitis C Virus Infected Adults
Status: COMPLETED
Conditions: Chronic Hepatitis C|Hepatitis C (HCV)|Hepatitis C Genotype 1a
Interventions: DRUG: ombitasvir/paritaprevir/ritonavir|DRUG: dasabuvir|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Near-infrared Light-emitting Diode (NIR-LED) Therapy for Leber's Hereditary Optic Neuropathy (LHON)
Status: TERMINATED
Conditions: Leber's Hereditary Optic Neuropathy (LHON)
Interventions: DEVICE: Near-infrared light-emitting diode (NIR-LED) therapy (Med Light 630 PRO (Medical Devices Inc.))
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CervIcal Cancer Screening Trial by Randomization of HPV Testing Intervention for Upcoming Screening （CITRUS Study）
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: OTHER: LBC|OTHER: LBC plus HPV DNA testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Behavioral Nudges for Diabetes Prevention (BEGIN) Trial in Primary Care
Status: ENROLLING_BY_INVITATION
Conditions: PreDiabetes
Interventions: BEHAVIORAL: Decision Aid intervention|BEHAVIORAL: Text Messaging intervention|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Talazoparib for Cohesin-Mutated AML and MDS With Excess Blasts
Status: RECRUITING
Conditions: Leukemia
Interventions: DRUG: Talazoparib|DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin for Chemoprevention of Lung Cancer in Overweight or Obese Individuals at High Risk for Lung Cancer
Status: RECRUITING
Conditions: Lung Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bronchoscopy|DRUG: Extended Release Metformin Hydrochloride|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Meals for Me: Drop Shipment Versus Personally-delivered Meals for Diabetes Management
Status: ENROLLING_BY_INVITATION
Conditions: Diabetes
Interventions: BEHAVIORAL: Waitlist|BEHAVIORAL: Medically tailored meals - Daily delivery with human interaction|BEHAVIORAL: Medically tailored meals - Weekly delivery with no human interaction|BEHAVIORAL: Medically tailored meals - Standard MOWCTX delivery with human interaction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Delta-THC in Dementia
Status: COMPLETED
Conditions: Behavioural Disturbances|Pain|Dementia|Alzheimer's Dementia|Vascular Dementia
Interventions: DRUG: delta-9-tetrahydrocannabinol (delta-THC)|DRUG: Placebo|DRUG: Acetaminophen|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Nivolumab +/- Docetaxel in Patients Previously Treated With Advanced or Metastatic NSCLC
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung|Docetaxel|Nivolumab
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT