pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Non-invasive Neurostimulation on Variability OF HEART RATE IN PATIENTS WITH HEART FAILURE.
Status: RECRUITING
Conditions: Heart Failure
Interventions: DEVICE: high definition transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Anterior Bridging Cage With Bone Substitute Versus Localized Autobone in Transforaminal Lumbar Interbody Arthrodesis
Status: COMPLETED
Conditions: Stenosis|Fusion of Spine (Disease)
Interventions: PROCEDURE: transforaminal lumbar interbody arthrodesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endocytoscopy and Colorectal Neoplasia
Status: COMPLETED
Conditions: Colon Cancer
Interventions: DEVICE: Endocystoscopy During Colonoscopy|DEVICE: Endocytoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Intraoperative Sonographically Guided Resection of Non-enhancing Gliomas
Status: RECRUITING
Conditions: Non-enhancing Cerebral Gliomas
Interventions: PROCEDURE: Intraoperative sonography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of SDF in Arresting Dental Caries in Preschool Children
Status: COMPLETED
Conditions: Early Childhood Caries
Interventions: DRUG: 12% SDF|DRUG: 38% SDF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of CF101 to Treat Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: CF101 1mg|DRUG: CF101 2mg|DRUG: CF101 4mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sofosbuvir/Velpatasvir/Voxilaprevir (SOF/VEL/VOX) for Patients With Hepatitis C Virus Infection
Status: UNKNOWN
Conditions: Hepatitis C Virus Infection|Treatment Side Effects|Adherence, Treatment|Effect of Drug
Interventions: DRUG: Vosevi 400/100/100 Oral Tablet
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intratympanic Steroid Treatment For The Prevention Of Inner Ear Toxicity Associated With Systemic Treatment With Cisplatin.
Status: UNKNOWN
Conditions: Cisplatin|Ototoxicity|Intratympanic Steroids
Interventions: DRUG: Intra-tympanic Cisplatinum
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessing Response to Neoadjuvant Chemotherapy With HD PET/CT, Serum Glycomic Markers and Tissue Muc-1 Isoforms
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DIAGNOSTIC_TEST: HD PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: bpMedManage: Digital Technology to Support Adherence to Hypertension Medications
Status: RECRUITING
Conditions: Aging|Mild Cognitive Impairment|Hypertension
Interventions: BEHAVIORAL: bpMedManage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: TAXUS IV-SR: Treatment of De Novo Coronary Disease Using a Single Paclitaxel-Eluting Stent
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: percutaneous coronary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Glucose Monitoring (CGM) Substudy of the DECIDE RCT
Status: NOT_YET_RECRUITING
Conditions: Gestational Diabetes Mellitus|Pregnancy, High Risk
Interventions: DEVICE: CGM device - Metformin group|DEVICE: CGM device - Insulin group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Single + Multiple Ascending Dose and Food Effect Study of AZD7986 in Healthy Volunteers, PK, PD and Safety Study
Status: COMPLETED
Conditions: Safety, Pharmacokinetics, Pharmacodynamics, Food Effect
Interventions: DRUG: AZD7986, oral solution, 1 to 50 mg/mL|DRUG: Placebo, oral solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Training of the Inspiratory Musculature in the Improvement of Inspiratory Strength and Muscle Recovery in Soccer Players
Status: WITHDRAWN
Conditions: Breathing
Interventions: OTHER: 50% resistance|OTHER: 10% resistance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Activity of IMAB362 in Combination With Zoledronic Acid and Interleukin-2 in CLDN18.2-positive Gastric Cancer
Status: COMPLETED
Conditions: CLDN18.2-positive Gastric Adenocarcinoma|CLDN18.2-positive Adenocarcinoma of the Gastroesophageal Junction|CLDN18.2-positive Adenocarcinoma of Esophagus
Interventions: DRUG: IMAB362|DRUG: Zoledronic acid|DRUG: Interleukin-2 (1 million IU)|DRUG: Interleukin-2 (3 million IU)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Quality of Life in Postmenopausal Women Who Are Receiving Either Exemestane or Anastrozole With or Without Celecoxib for Stage I, Stage II, or Stage IIIA Primary Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: quality-of-life assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Plantar Fasciitis With Injection af Platelet-rich Plasma Into the Origin of the Plantar Fascia
Status: UNKNOWN
Conditions: Plantar Fasciitis
Interventions: BIOLOGICAL: Plasma|BIOLOGICAL: Saline|OTHER: Physiotherapy + heel cap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Serratus Anterior Blockade for Sternotomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Postoperative Pain|Opioid Use|Quality of Life
Interventions: PROCEDURE: Serratus anterior plane (SAP) block|PROCEDURE: Normal saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of XIAP Antisense Given With Chemotherapy for Refractory/Relapsed AML
Status: COMPLETED
Conditions: Leukemia, Myelomonocytic, Acute
Interventions: DRUG: XIAP antisense
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Different Oral Rehydration Solutions on the Hydration Status of Healthy Males
Status: COMPLETED
Conditions: Fluid Retention|Beverage Hydration Index|Hydration Status
Interventions: OTHER: Test product 1|OTHER: Test product 2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PORTEC-4a: Molecular Profile-based Versus Standard Adjuvant Radiotherapy in Endometrial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Cancer Stage I|Endometrial Cancer Stage II
Interventions: RADIATION: Vaginal brachytherapy|RADIATION: External beam radiotherapy|OTHER: Observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Cannabis Use for Sleep Among Adults Using Medical Cannabis
Status: COMPLETED
Conditions: Insomnia Chronic|Cannabis Use
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia in Cannabis Users (CBTi-CB)|BEHAVIORAL: Sleep Hygiene Education (SHE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: filgrastim|DRUG: cytarabine|DRUG: etoposide|DRUG: hydroxyurea|DRUG: mitoxantrone hydrochloride|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Dose-Response Study of the Safety and Uric Acid Effects of Oral Ulodesine Added to Allopurinol in Subjects With Gout and Concomitant Moderate Renal Insufficiency
Status: COMPLETED
Conditions: Gout|Hyperuricemia|Arthritis|Joint Disease|Renal Insufficiency
Interventions: DRUG: Placebo|DRUG: Ulodesine (BCX4208) 5 mg|DRUG: Ulodesine (BCX4208) 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Telephone Administered Psychotherapy for the Treatment of Depression for Veterans in Rural Areas
Status: COMPLETED
Conditions: Heart Failure|Beta-blocker Treatment
Interventions: BEHAVIORAL: GTelephone-administered Cognitive-Behavioral Therapy (T-CBT)|PROCEDURE: Provider education, computer reminders, nurse case management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluvoxamine and Sertraline in Childhood Autism - Does SSRI Therapy Improve Behaviour and/or Mood?
Status: COMPLETED
Conditions: Autism
Interventions: DRUG: fluvoxamine|DRUG: sertraline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Robotic Surgery for Right Colon Cancer
Status: NOT_YET_RECRUITING
Conditions: Colon Cancer|Robotic Surgery
Interventions: PROCEDURE: DaVinci si or xi system|PROCEDURE: laparoscopic radical resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension)
Status: COMPLETED
Conditions: Opioid Use Disorder
Interventions: DRUG: NTX/BUP|DRUG: NTX/PBO-B|DRUG: PBO-N/PBO-B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: EMPACT-MI: A Study to Test Whether Empagliflozin Can Lower the Risk of Heart Failure and Death in People Who Had a Heart Attack (Myocardial Infarction)
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: Empagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mobile Health Technology for Chronic Kidney Disease Patients: Medication Management
Status: COMPLETED
Conditions: Renal Insufficiency, Chronic|Hypertension|Medication Reconciliation|Mobile Applications
Interventions: OTHER: Usual Care|DEVICE: Integrated mobile medication app|DEVICE: Commercially available mobile medication app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Induction Versus Adjuvant Gemcitabine/Cisplatin in Locally Advanced Non-metastatic Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Gemcitabin/cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of EPA and DHA From Two Dietary Supplements
Status: UNKNOWN
Conditions: Hypertriglyceridemia
Interventions: DIETARY_SUPPLEMENT: DHA-rich fish oil versus Phospholipid-rich fish oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Indocyanine Green and Rectosigmoid Endometriosis
Status: UNKNOWN
Conditions: Endometriosis, Rectum|Bowel Endometriosis
Interventions: DIAGNOSTIC_TEST: assessment of bowel symptoms before surgery|DIAGNOSTIC_TEST: assessment of rectosigmoid during laparoscopy|DIAGNOSTIC_TEST: follow up and assessment of bowel symptoms after surgery|DIAGNOSTIC_TEST: assessment of rectosigmoid perfusion during robot-assisted laparoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: High Intensity Interval Training Versus Low-intensity Continuous Training on Physical Fitness Among Overweight Adult
Status: UNKNOWN
Conditions: Overweight|Overweight and Obesity
Interventions: OTHER: High-intensity Interval Training|OTHER: Low-intensity Continuous Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation
Status: RECRUITING
Conditions: Lung Cancer|Non Small Cell Lung Cancer|Colorectal Cancer|Cancer of Pancreas|Colon Cancer|Solid Tumor|Cancer
Interventions: DRUG: HBI-2438
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Complex Regional Pain Syndrome in Children: Impact of Bergès Relaxation on the Autonomic Balance
Status: TERMINATED
Conditions: Complex Regional Pain Syndrome Type I
Interventions: DIAGNOSTIC_TEST: questionnaires|DIAGNOSTIC_TEST: holter electrocardiogram|DIAGNOSTIC_TEST: blood pressure|OTHER: relaxation sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Examining B12 Deficiency Associated With C677T Mutation on MTHFR Gene in Terms of Commonness and Endothelial Function
Status: TERMINATED
Conditions: B12 Deficiency Combined With C677T Mutation on MTHFR Gene
Interventions: DIETARY_SUPPLEMENT: Vitamin B12 + Folic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Spinal Morphine in Robotic Assisted Radical Prostatectomy
Status: COMPLETED
Conditions: Morphine|Injections, Spinal|Prostatectomy|Patient Satisfaction
Interventions: DRUG: Morphine|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Non-small Cell Lung Cancer With PD-1 Monoclonal Antibody Combined With Donafenib Toluene Sulfonate
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: donafenib tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vascular Health and Risk Factors in Children With Down Syndrome
Status: COMPLETED
Conditions: Down Syndrome|Cardiovascular Risk Factor|Atherosclerosis
Interventions: OTHER: Evaluate vascular disease risk factors in children with Down Syndrome|OTHER: Determine the associations between cardiovascular disease risk factors and markers of early atherosclerosis in children with Down Syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess the Safety and Efficacy of Infliximab to Treat Hidradenitis Suppurtativa
Status: COMPLETED
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: infliximab|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: [68Ga]Ga-NOTA-RW102 PET Imaging in the Diagnosis of PD-L1-expressing Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: RADIATION: [68Ga]Ga-NOTA-RW102 PET Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Topical 10 % Nifedipine Versus 5% Sildenafil in Secondary Raynaud
Status: COMPLETED
Conditions: Raynaud Phenomenon Due to Trauma|Raynaud Disease|System; Sclerosis|Lupus Erythematosus, Systemic|Dermatomyositis|Ultrasound Therapy; Complications
Interventions: DRUG: 10% nifedipine cream|DRUG: 5% sildenafil cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Sprinkles on Infectious Morbidity When Moderate to Severe Pediatric Malnutrition Is Highly Prevalent
Status: COMPLETED
Conditions: Malnutrition|Iron Deficiency
Interventions: DIETARY_SUPPLEMENT: Oral Iron Supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gilenya in Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Gilenya|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Menstrual Migraine With Sequential, Transdermal, 17-Beta-Estradiol. A Double-Blind, Randomised, Cross-Over Trial.
Status: UNKNOWN
Conditions: Migraine
Interventions: DRUG: 17-beta-estradiol (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Control of Myopia Using Novel Spectacle Lens Designs
Status: ACTIVE_NOT_RECRUITING
Conditions: Juvenile Myopia
Interventions: DEVICE: Novel spectacle lens design|DEVICE: Spectacle lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy and Safety of Single and Multiple Therapy of Herbal Medicine/Chuna Therapy on Non-specific Chronic Low Back Pain: A Study Protocol for Multicenter, 3-arm, Randomized, Single Blinded, Parallel Group, Incomplete Factorial Design, Pilot Study -
Status: UNKNOWN
Conditions: Chronic Low Back Pain
Interventions: DRUG: Sogyeonghwalhyeol-tang granule|OTHER: Sogyeonghwalhyeol-tang granule with manipulation procedure|OTHER: Placebo with manipulation procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cycled Testosterone Therapy to Improve Physical Function in Frail Nursing Home Residents
Status: TERMINATED
Conditions: Aging
Interventions: DRUG: Placebo|DRUG: Testosterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: DIMINI - Diabetes Mellitus? - Not me!
Status: UNKNOWN
Conditions: Health Behavior|Health Knowledge, Attitudes, Practice|Literacy|Diabetes Mellitus, Type 2|Diabetes
Interventions: BEHAVIORAL: DIMINI lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Pre-operative Intranasal Oxytocin for Enhancing Bariatric-induced Diabetes Remission
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Diabetes|Bariatric Surgery
Interventions: DRUG: Oxytocin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanistic Insights to Weight Loss Maintenance Through SGLT2 Inhibitors
Status: WITHDRAWN
Conditions: Obesity|Weight Loss
Interventions: DRUG: Empagliflozin Arm|OTHER: Control Arm|OTHER: Exercise capacity VO2 maximum determination|OTHER: Exercise Challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Effect of Omeprazole on the Pharmacokinetics of BMS-986205 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BMS-986205|DRUG: omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Breast-Conserving Therapy in Patients With Triple-Negative Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: PROCEDURE: Breast-Conserving Therapy|PROCEDURE: Mastectomy|DRUG: Adjuvant Chemotherapy|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety of Current Standard Malaria Treatment and an Assessment of G6PD Status in South-east Bangladesh
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: chloroquine|DRUG: Artemether-lumefantrine combination|DRUG: Primaquine|DRUG: Primaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CARDIO-TTRansform Magnetic Resonance Imaging (MRI) Sub-study
Status: ACTIVE_NOT_RECRUITING
Conditions: Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)
Interventions: DIAGNOSTIC_TEST: Cardiac MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fluorine F 18 EF5 PET/CT Imaging in Patients With Locally Advanced or Recurrent/Metastatic Cervical Cancer
Status: TERMINATED
Conditions: Cervical Cancer
Interventions: RADIATION: fludeoxyglucose F 18|RADIATION: fluorine F 18 EF5
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Acupuncture for Breast Pain
Status: RECRUITING
Conditions: Acupuncture|Mastodynia
Interventions: DEVICE: Acupuncture|DEVICE: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 18F-FDG PET/CT and Molecular Tumor Characterisation for Staging and Follow-up of Colon Cancer
Status: UNKNOWN
Conditions: Colon Cancer
Interventions: OTHER: 18F-fluordeoxyglucose positron emission tomography/ computed tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Research of CD19 Targeted CAR-T Cell in Relapsed/Refractory B Cell Lymphoma
Status: RECRUITING
Conditions: B Cell Lymphoma|Non Hodgkin Lymphoma
Interventions: BIOLOGICAL: MC-1-50
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavior Therapy for Work Success in Veterans With Mental Illness: A Pre-post Efficacy Study
Status: COMPLETED
Conditions: Mental Disorders|Mental Health Services
Interventions: BEHAVIORAL: Cognitive behavior therapy for work success (CBTw)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Effects of Local Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in Adjuvant Administration on Dendritic Cells in Skin of Melanoma Patients and in Sentinel Lymph Nodes: MEL38
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: GM-CSF-in-adjuvant|DRUG: Montanide ISA-51|BIOLOGICAL: GM-CSF and Montanide ISA-51|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Multicenter Cohort Study of Urinary Exosome lncRNAs for Preoperative Diagnosis of Lymphatic Metastasis in Patients With Bladder Cancer
Status: NOT_YET_RECRUITING
Conditions: Explore Whether lncRNA-ElNAT1 in Urine Exosomes Can be Used as a New Target for Preoperative Diagnosis of Lymph Node Metastasis
Interventions: OTHER: no intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reducing Beverages and Sugar and Increasing Physical Activity in Public School Adolescents From Brazil
Status: COMPLETED
Conditions: Sugar Intake|Beverage Intake|Fruit Intake|Beans Intake|Physical Activity
Interventions: BEHAVIORAL: lifestyle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Atrial Pressure Electrophysiology Pilot Study
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: DEVICE: ThermoCool® SF NAV Catheter|DEVICE: ThermoCool® catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Tolerability and Pharmacokinetics of Toripalimab in Combination With Axitinib in Patients With Kidney Cancer and Melanoma
Status: UNKNOWN
Conditions: Kidney Cancer Stage Iv|Advanced Melanoma
Interventions: BIOLOGICAL: humanized anti-PD-1 monoclonal antibody Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beta-Blockers in Takotsubo Syndrome Study
Status: NOT_YET_RECRUITING
Conditions: Takotsubo Cardiomyopathy|Beta-blockers|Echocardiography|Left Ventricular Function
Interventions: DRUG: Beta blocker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alternating Icotinib and Chemotherapy for Advanced Non-small Cell Lung Cancer With EGFR Mutation
Status: UNKNOWN
Conditions: Lung Adenocarcinoma
Interventions: DRUG: Icotinib|DRUG: Pemetrexed/Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Unicentric Comparing Study of Suction Curettage With Standard BOTOX Injection in the Treatment of Patients With Essential Axillar Hyperhidrosis: Comparing of Efficacy, Duration of Effectiveness, and Adverse Events.
Status: TERMINATED
Conditions: Essential Axillary Hyperhidrosis
Interventions: PROCEDURE: Suction curettage|DRUG: Treatment with Botox
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Treatment With Melatonin to Treatment With Stimulants (Methylphenidate) in Children With Attention Deficit Hyperactivity Disorder and Sleep Difficulties
Status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder|Sleep Onset Insomnia
Interventions: DRUG: Melatonin|DRUG: Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Caesarean Section Incisional Infiltration With Lidocaine Versus Lidocaine and Epinephrine
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Lidocaine|DRUG: lidocaine and Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Safety and Efficacy of E/C/F/TDF Versus RTV-Boosted ATV Plus FTC/TDF in HIV-1 Infected, Antiretroviral Treatment-Naive Women
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome|HIV Infections
Interventions: DRUG: E/C/F/TDF|DRUG: ATV|DRUG: RTV|DRUG: FTC/TDF|DRUG: E/C/F/TDF Placebo|DRUG: ATV Placebo|DRUG: RTV Placebo|DRUG: FTC/TDF Placebo|DRUG: E/C/F/TAF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Alcoholic Beverages in Pro-inflammatory and Antioxidant Profile After an Oral Fat Diet
Status: COMPLETED
Conditions: Alcohol Consumption
Interventions: OTHER: Oral fat diet plus water with sugar|OTHER: Oral fat diet plus alcoholic beverages
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ultrasound Guided Modified Pectoral Plane Block Versus Erector Spinae Plane Block During GA in Gynecomastia Surgery
Status: COMPLETED
Conditions: Gynecomastia, Adolescent
Interventions: PROCEDURE: PECS II versus ESP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Harmony TPV Post-Approval Study
Status: RECRUITING
Conditions: Congenital Heart Disease|Tetrology of Fallot|RVOT Anomaly|Pulmonary Regurgitation
Interventions: DEVICE: Harmony TPV System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Latanoprost Eluting Contact Lens for Treating Glaucoma and Ocular Hypertension
Status: RECRUITING
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: Latanoprost eluting contact lens|DRUG: Topical Latanoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity
Status: NOT_YET_RECRUITING
Conditions: Ketosis|Essential Hypertension
Interventions: DIETARY_SUPPLEMENT: Ketone Monoester (KE4)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Novel RNA-nanoparticle Vaccine for the Treatment of Early Melanoma Recurrence Following Adjuvant Anti-PD-1 Antibody Therapy
Status: RECRUITING
Conditions: Melanoma
Interventions: BIOLOGICAL: Autologous total tumor mRNA loaded DOTAP liposome vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CGC-11047 When Used in Individual Combinations With 1) Gemcitabine or 2) Docetaxel or 3) Bevacizumab or 4) Erlotinib or 5) Cisplatin or 6) 5-Flurouracil or 7) Sunitinib in Patients With Advanced Solid Tumors or Lymphoma
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: CGC-11047 and gemcitabine|DRUG: CGC-11047 and docetaxel|DRUG: CGC-11047 and bevacizumab|DRUG: CGC-11047 and erlotinib|DRUG: CGC-11047 and cisplatin|DRUG: CGC-11047 and 5-flurouracil / leucovorin|DRUG: CGC-11047 and sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Novel RADA16 Hydrogel in Endoscopic Skull Base Surgery
Status: RECRUITING
Conditions: Skull Base Neoplasms|Cerebrospinal Fluid Leakage|Nasal; Hypertrophy, Mucous Membrane (Septum)
Interventions: DEVICE: Non-Absorbable Packing (Silastic Splint)|DEVICE: PuraGel (RADA16) Hydrogel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of 70% Ethanol Versus Heparin to Reduce the Rate of Central Line Infections in Children With Short Bowel Syndrome
Status: WITHDRAWN
Conditions: Catheter Related Infections|Short Bowel Syndrome
Interventions: DRUG: 70% ethanol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Bracing to Treat Knee Osteoarthritis in Elderly
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Brace (Fisiotensor®)|DEVICE: Sleeve (Fisiotensor®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment Combining Riluzole and IFB-088 in Bulbar Amyotrophic Lateral Sclerosis (TRIALS Protocol)
Status: ACTIVE_NOT_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis|ALS
Interventions: DRUG: IFB-088 50mg/day|DRUG: Placebo|DRUG: Riluzole 100mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Great Occipital Nerve and Supraorbital Nerve Blockade Methods at Treatment of Acute Migraine Attack in the Emergency Department
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: DRUG: Lidocaine Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Re-Administration of C134 in Patients With Recurrent GBM (C134-HSV-1)
Status: NOT_YET_RECRUITING
Conditions: Recurrent Malignant Glioma|Glioblastoma Multiforme of Brain|Gliosarcoma of Brain|Anaplastic Astrocytoma of Brain
Interventions: DRUG: C134 Re-Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Decline and Underlying Mechanisms in Symptomatic Intracranial Artery Stenosis Patients: A Cohort Study
Status: RECRUITING
Conditions: Intracranial Atherosclerosis|Cognitive Impairment|Cerebrovascular Event
Interventions: DRUG: Aspirin Tablet, Clopidogrel Bisulfate Tablets and Atorvastatin|PROCEDURE: Endovascular therapy,Aspirin Tablet, Clopidogrel Bisulfate Tablets and Atorvastatin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Aerobic Exercises vs Device Guided Breathing on Gestational Hypertension
Status: COMPLETED
Conditions: Hypertension ,Pregnancy
Interventions: OTHER: Aerobic exercise|DEVICE: Device guided breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validating a Novel Approach to Assess Metabolic Flexibility in a Respiratory Chamber
Status: COMPLETED
Conditions: Metabolism
Interventions: PROCEDURE: Overnight Metabolic Flexibility|PROCEDURE: Clamp Metabolic Flexibility
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods
Status: COMPLETED
Conditions: Reduced Sperm Motility|IVF|ICSI|Astheno Teratozoospermia
Interventions: DEVICE: Microfluidic sperm sorting chip|DEVICE: Density gradient
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Relaxing Breathing Exercise Applied to Patients Before Bone Marrow Biopsy on Vital Signs, Pain and Anxiety Levels
Status: NOT_YET_RECRUITING
Conditions: Bone Marrow Cancer
Interventions: BEHAVIORAL: relaxing breathing exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis
Status: TERMINATED
Conditions: Stroke|Intracranial Atherosclerosis|Intraplaque Hemorrhage
Interventions: DRUG: Alirocumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Infusion of Prostacyclin vs Placebo for 72-hours in Mechanically Ventilated Patients With Acute Respiratory Failure
Status: RECRUITING
Conditions: Acute Respiratory Failure|Endothelial Dysfunction|Pulmonary Infection
Interventions: DRUG: Iloprost|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy, Longitudinal Costs and Patient-Centered Outcomes Using a TAAA Debranching Device
Status: TERMINATED
Conditions: Thoracoabdominal Aortic Aneurysm
Interventions: DEVICE: Visceral Manifold and Thoracic Bifurcation|DEVICE: Unitary Manifold|DEVICE: TAAA Debranching Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Co-Administration of MK-4618 With Antihypertensive Agents (MK-4618-010)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: MK-4618|DRUG: Placebo for MK-4618|DRUG: Metoprolol|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Efficacy and Safety of CKD-391 and CKD-331 in Patients With Primary Hypercholesterolemia
Status: RECRUITING
Conditions: Primary Hypercholesterolemia
Interventions: DRUG: D377|DRUG: CKD-331|DRUG: D086|DRUG: Placebo (for D377)|DRUG: Placebo (for CKD-331)|DRUG: Placebo (for D086)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Staple vs. Suture in Robotic Prostatectomy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: Staple Ligation|PROCEDURE: Selective Suture Ligation|PROCEDURE: Single Suture Ligation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab and Tovorafenib for Treatment of Craniopharyngioma in Children and Young Adults
Status: RECRUITING
Conditions: Craniopharyngioma, Child|Craniopharyngioma|Recurrent Craniopharyngioma
Interventions: DRUG: Nivolumab|DRUG: Tovorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pharmacokinetic Interaction Between Combivir® (ZDV+3TC) and BILR 355 BS Plus Ritonavir in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BILR 355 BS|DRUG: Combivir®|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fedratinib in Combination With Nivolumab
Status: RECRUITING
Conditions: Primary Myelofibrosis|Secondary Myelofibrosis
Interventions: DRUG: Fedratinib Oral Capsule [Inrebic]|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Japanese Pegylated Interferon (PegIFN) Alfa-2b/Ribavirin (RBV) Combination Trial
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: BI 201335 high dose|DRUG: BI 201335 low dose|DRUG: BI 201335 high dose|DRUG: BI 201335 high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Trial of Azithromycin vs. Doxycycline for the Treatment of Rectal Chlamydia in MSM
Status: COMPLETED
Conditions: Anal Chlamydia Infection
Interventions: DRUG: Azithromycin|DRUG: Doxycycline|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pivotal Study of a Percutaneous Mitral Valve Repair System
Status: COMPLETED
Conditions: Mitral Valve Insufficiency|Mitral Valve Regurgitation|Mitral Valve Incompetence|Mitral Regurgitation|Mitral Insufficiency
Interventions: DEVICE: Percutaneous mitral valve repair using MitraClip implant|PROCEDURE: Mitral valve repair or replacement surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Standardized Management of Hypertension in Rural Shaanxi
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Hydrochlorothiazide, Captopril, Nitrendipine, Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Study on Myoelectric Elbow-Wrist-Hand Orthosis User Outcomes
Status: COMPLETED
Conditions: Stroke|Brachial Plexus Injury|Spinal Cord Injuries|Neurological Disease
Interventions: DEVICE: Myoelectric Elbow-Wrist-Hand Orthosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Switch From Tenofovir to Raltegravir for Low Bone Mineral Density
Status: COMPLETED
Conditions: HIV|Osteopenia|Osteoporosis|HIV Infections
Interventions: DRUG: Raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TSA v RSA in Osteoarthritic Shoulders With Greater Than 15 Degrees of Retroversion
Status: RECRUITING
Conditions: Osteoarthritis Shoulder
Interventions: PROCEDURE: Total Shoulder Arthroplasty + augmented glenoid component|PROCEDURE: Reverse Shoulder Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Methadone Induced Memory Retrieval-extinction Procedure in Heroin Addicts
Status: COMPLETED
Conditions: Heroin Dependence
Interventions: BEHAVIORAL: methadone induced memory retrieval-extinction procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD)
Status: COMPLETED
Conditions: Anemia|Non-Dialysis-Dependent Chronic Kidney Disease
Interventions: DRUG: Vadadustat|DRUG: Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Walking in People With Incomplete Spinal Cord Injury: a Pilot Study
Status: COMPLETED
Conditions: Motor-incomplete Spinal Cord Injury
Interventions: BEHAVIORAL: Body-weight supported treadmill training|BEHAVIORAL: Body-weight supported treadmill training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: GEN1046 in Combination With Anticancer Agents for the Treatment of Advanced Endometrial Cancer
Status: WITHDRAWN
Conditions: Advanced Endometrial Cancer
Interventions: BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Acasunlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DECT for Differentiating Intracerebral Hemorrhage From Contrast Extravasation
Status: RECRUITING
Conditions: Stroke, Ischemic|Tomography, X-Ray Computed
Interventions: DIAGNOSTIC_TEST: Dual Energy CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Tolerability and Efficacy of TransCon hGH Weekly Versus Daily hGH in Chinese Pediatric Growth Hormone Deficiency
Status: UNKNOWN
Conditions: Growth Hormone Deficiency|Endocrine System Diseases|Hormones|Pituitary Diseases|Pituitary Disease, Anterior
Interventions: DRUG: TransCon hGH|DRUG: daily hGH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addiction Risk: Psychoeducational Intervention to Change Risk Perception Among Alcohol Patients in Residential Treatment
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: BEHAVIORAL: Psychoeducational Group Intervention on Alcohol Drinking Related to Stress|BEHAVIORAL: Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Finerenone for Patients With Primary Aldosteronism (FAIRY)
Status: RECRUITING
Conditions: Primary Aldosteronism
Interventions: DRUG: Finerenone Oral Tablet|DRUG: Spironolactone Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Food, Formulation Strength, and a Proton Pump Inhibitor on GED 0301 Pharmacokinetics in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: GED-0301|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Moxibustion in the Treatment of Hemorrhagic Cystitis After Allo-HSCT
Status: RECRUITING
Conditions: Moxibustion|Hematopoietic Stem Cell Transplantation|Hemorrhagic Cystitis|Treatment
Interventions: OTHER: Moxibustion|OTHER: Symptomatic supportive treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RECOVAC Repeated Vaccination Study
Status: COMPLETED
Conditions: Covid19|Kidney Diseases|Vaccine Response Impaired|SARS-CoV2 Infection
Interventions: BIOLOGICAL: mRNA-1273|BIOLOGICAL: Ad26.COV2.S vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION