pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: ²¹¹At-OKT10-B10 and Fludarabine Alone or in Combination With Cyclophosphamide and Low-Dose TBI Before Donor Stem Cell Transplant for the Treatment of Newly Diagnosed, Recurrent, or Refractory High-Risk Multiple Myeloma
Status: NOT_YET_RECRUITING
Conditions: Plasma Cell Myeloma|Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|BIOLOGICAL: Astatine At 211 Anti-CD38 Monoclonal Antibody OKT10-B10|DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate|RADIATION: Total-Body Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualized Lung Tumor Stereotactic Ablative Radiotherapy (iSABR)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: RADIATION: iSABR, 25 Gray in 1 fraction for small peripheral tumors|RADIATION: iSABR, 50 Gray in 4 fractions for medium peripheral tumors|RADIATION: iSABR, 54 Gray in 3 fractions for large peripheral tumors|RADIATION: iSABR, 40 Gray in 4 fractions for small central tumors|RADIATION: iSABR, 50 Gray in 4 fractions for medium central tumors|RADIATION: iSABR, 60 Gray in 8 fractions for large central tumors
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: DNA Methylation in Malar Melasma and Its Change by Sunscreen, Retinoic Acid and Niacinamide.
Status: COMPLETED
Conditions: Melasma
Interventions: DRUG: Retinoic acid|DEVICE: colorimetry measurement|DRUG: sunscreen|DRUG: Niacinamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Apatinib Combined With cdk4/6i in First-line Treatment for HR+/HER2- SNF4 Subtype Breast Cancer
Status: RECRUITING
Conditions: Advanced Breast Cancer|HR+/HER2- Breast Cancer
Interventions: DRUG: Apatinib|DRUG: CDK4/6 Inhibitor|DRUG: Aromatase inhibitor and Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analysis of Inflammatory Predictors and Gene Expression in Patients With Mild Cognitive Impairment
Status: UNKNOWN
Conditions: Cognitive Decline
Interventions: DEVICE: Direct Current Transcranial Stimulation - tDCS|DEVICE: Sham Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Assessment of Single-Dose Safety,Tolerability, Pharmacokinetics and Pharmacodynamic of Globalagliatin Hydrochloride
Status: COMPLETED
Conditions: Hyperglycaemia (Diabetic)|Healthy Volunteers
Interventions: DRUG: globalagliatin hydrochloride|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of GSK256073 in Subjects With Type 2 Diabetes Mellitus Who Are Being Treated With Metformin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: GSK256073 1mg|DRUG: GSK256073 5mg|DRUG: GSK256073 10mg|DRUG: GSK256073 25mg|DRUG: Placebo|DRUG: Sitagliptin 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Blood Pressure Lowering Effect of a Candemore Plus Tab Versus Cantabell Tab in Hypertensive Patients Inadequately Controlled by Candesartan Monotherapy
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Cantabell Tab|DRUG: Candemore Plus Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cod Liver Oil for Covid-19 Prevention Study
Status: COMPLETED
Conditions: Covid-19|Respiratory Tract Infections
Interventions: DIETARY_SUPPLEMENT: Cod liver oil|DIETARY_SUPPLEMENT: Corn oil (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of rhuFab V2 (Ranibizumab) in Subjects With Subfoveal Choroidal Neovascularization Secondary to Age-Related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: rhuFab V2 (ranibizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Immediate Load of Dental Implants, Placed in Atrophic Upper and/or Lower Jaw of Partial or Complete Edentate Patients, According to Flapless Technique
Status: COMPLETED
Conditions: Dental Implants
Interventions: PROCEDURE: Placement of functional loaded synthetic teeth after placement implants
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Reirradiation in Bevacizumab Naïve and Bevacizumab Resistant Recurrent Glioblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: Pembrolizumab|DRUG: Bevacizumab|RADIATION: Re-irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biting Force in Heat Cured Acrylic Resin Versus CAD/CAM Maxillary Single Denture Bases
Status: UNKNOWN
Conditions: Bites, Human
Interventions: OTHER: cad/cam maxillary dentures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Plasmonic Photothermal and Stem Cell Therapy of Atherosclerosis Versus Stenting
Status: TERMINATED
Conditions: Coronary Artery Disease|Atherosclerosis
Interventions: OTHER: Stenting and micro-infusion of NP|DEVICE: Implantation of everolimus-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-blind, Placebo-controlled Study of the Safety and Efficacy of Paliperidone Extended Release (ER) in the Treatment of Schizophrenia in Adolescent Patients
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Paliperidone ER|DRUG: Placebo|DRUG: Paliperidone ER|DRUG: Paliperidone ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blood Flow Restriction After Meniscus Repair
Status: RECRUITING
Conditions: Meniscus Disorder|Meniscus, Torn Tibial|Meniscus Lesion|Meniscus Tear, Tibial|Atrophy, Muscular
Interventions: DEVICE: Blood flow restriction (Delfi Personalized Tourniquet System)|OTHER: Standard rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Flavonols and Endothelial Injury
Status: COMPLETED
Conditions: Endothelial Dysfunction
Interventions: DIETARY_SUPPLEMENT: with Flavanol|DIETARY_SUPPLEMENT: without Flavanol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Can Time-lapse Parameters be Used to Predict Pregnancy of Human Embryos?
Status: TERMINATED
Conditions: Infertility
Interventions: OTHER: Time lapse monitoring (KID Score)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact in Off-spring of Mothers After Perinatal Daily Intake of a Probiotic
Status: COMPLETED
Conditions: Asthma|Dermatitis, Atopic|Rhinitis, Allergic, Perennial
Interventions: DIETARY_SUPPLEMENT: Probiotic|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hybrid Sirolimus-eluting Versus Everolimus-eluting Stents for Total Coronary Occlusions
Status: UNKNOWN
Conditions: Coronary Artery Disease|Coronary Disease|Coronary Stenosis
Interventions: DEVICE: Hybrid sirolimus- and everolimus-eluting stents (ORSIRO, XIENCE PRIME)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Soluble Epoxide Hydrolase Inhibition and Insulin Resistance
Status: COMPLETED
Conditions: Diabetes Mellitus|Endocrine System Diseases|Glucose Metabolism Disorders|PreDiabetes|Obesity
Interventions: DRUG: GSK2256294|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Rosuvastatin on Diabetic Patients Treated With Glimepiride/Metformin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Rosuvastatin10 mg tablet|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Oncoplastic Breast Surgery on the Oncological Safety and Patient Satisfaction
Status: COMPLETED
Conditions: Non Metastatic Breast Cancer
Interventions: PROCEDURE: Standard quadrantectomy|PROCEDURE: oncoplastic breast surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III of Cabazitaxel and Pelvic Radiotherapy in Localized Prostate Cancer and High-risk Features of Relapse
Status: ACTIVE_NOT_RECRUITING
Conditions: Adenocarcinoma of Prostate|Progression of Prostate Cancer
Interventions: DRUG: Cabazitaxel|RADIATION: Pelvic radiotherapy|RADIATION: prostate radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allopurinol Add-on Treatment for Refractory Mania
Status: COMPLETED
Conditions: Bipolar Disorder|Mixed Mania|Treatment-Resistant Mania
Interventions: DRUG: Allopurinol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Rehabilitation in Severely Acutely Malnourished Children
Status: COMPLETED
Conditions: Severe Acute Malnutrition|Kwashiorkor|Nutritional Edema|Marasmus
Interventions: DIETARY_SUPPLEMENT: Standard F75|DIETARY_SUPPLEMENT: Alternative F75 With CMV|DIETARY_SUPPLEMENT: Alternative F75 Without CMV|DIETARY_SUPPLEMENT: F100|DIETARY_SUPPLEMENT: Standard F75 + RUTF|DIETARY_SUPPLEMENT: Alternative F75 with CMV + RUTF|DIETARY_SUPPLEMENT: Alternative F75 without CMV + RUTF
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Hibiscus and Lippia Extract on Blood Pressure
Status: COMPLETED
Conditions: Blood Pressure
Interventions: DIETARY_SUPPLEMENT: Metabolaid®|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nasal Gel for the Prevention of Nausea and Vomiting Associated With Motion
Status: COMPLETED
Conditions: Motion Sickness
Interventions: DRUG: DPI-386 Nasal Gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vegetarian Diet and Innate Immunity in Patients With Myocardial Infarction and in Healthy Volunteers (FRESH-MI Study)
Status: RECRUITING
Conditions: Myocardial Infarction
Interventions: OTHER: Vegetarian diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Ascending, Subcutaneous, Single and Multiple Doses of SHP681 (Glucagon-like Peptide-2 [GLP-2] Analog-Fc Fusion) in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: SHP681|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Ice-therapy for Intravitreal Injections
Status: RECRUITING
Conditions: Anesthesia; Hypothermia|Injection Site Irritation
Interventions: OTHER: Ice-therapy|OTHER: No Ice-therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: STUDY OF THE ADDED VALUE OF A TRANSMURAL EVALUATION IN PATIENTS WITH CROHN'S DISEASE UNDER BIOTHERAPY WITH CLOSE FECAL CALPROTECTIN FOLLOW-UP
Status: RECRUITING
Conditions: Crohn Disease|Calprotectin|MRI
Interventions: RADIATION: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prospective Observational Study of Concomitant Allergic Rhinitis Treatment Patterns Among Patients Starting on Fluticasone Furoate Nasal Spray in a Retail Pharmacy Setting
Status: TERMINATED
Conditions: Rhinitis, Allergic, Seasonal|Seasonal Allergic Rhinitis
Interventions: DRUG: Fluticasone furoate nasal spray
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of LY2963016 Compared to Lantus® in Adult Chinese Participants With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: LY2963016|DRUG: Lantus®|DRUG: Insulin Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of Sodium Oxybate in the Long-term Maintenance of Abstinence in Alcoholic Patients
Status: COMPLETED
Conditions: Alcohol Use Disorder (AUD)|Alcohol Dependence
Interventions: DRUG: Sodium Oxybate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Alicaforsen in Pouchitis Patients Who Have Failed to Respond to at Least One Course of Antibiotics
Status: COMPLETED
Conditions: Pouchitis
Interventions: DRUG: Alicaforsen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of COVID-19 Convalescent Plasma
Status: COMPLETED
Conditions: Convalescent Plasma|COVID-19|SARS-CoV 2
Interventions: BIOLOGICAL: anti-SARS-CoV-2 convalescent plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Gene Modified Donor T-cells Following Partially Mismatched Stem Cell Transplant
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Acute Myelogenous Leukemia|Lymphoma|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: BPX-501 dose 1|DRUG: Rimiducid|BIOLOGICAL: BPX-501 dose 2|BIOLOGICAL: BPX-501 dose 3|BIOLOGICAL: BPX-501 dose 4|PROCEDURE: SCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Ambulation on the Return of Bowel Function After Colorectal Surgery
Status: TERMINATED
Conditions: Return of Bowel Function After Colon Surgery
Interventions: PROCEDURE: Ambulation regimen|DRUG: Sitz-Markers|RADIATION: Daily abdominal x-rays|DEVICE: pedometers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Supportive Care Questionnaires in Gathering Data on Unmet Needs and Health-Related Quality of Life in Latina Breast Cancer Survivors After Surgery, Chemotherapy, or Radiation Therapy
Status: COMPLETED
Conditions: Breast Carcinoma|Cancer Survivor
Interventions: OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Primidone on Platelet Responsiveness in Patients Determined to be Clopidogrel Resistant
Status: WITHDRAWN
Conditions: Clopidogrel Resistance|Secondary Stroke Prevention
Interventions: DRUG: Primidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total Marrow and Lymphoid Irradiation and Chemotherapy for High-Risk Acute Leukemia
Status: UNKNOWN
Conditions: Acute Leukemia
Interventions: RADIATION: total body irradiation|RADIATION: total marrow and lymphoid irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute and Short-term Effects of CBD on Cue-induced Craving in Drug-abstinent Heroin-dependent Humans
Status: COMPLETED
Conditions: Opiate Addiction
Interventions: DRUG: CBD 400 mg|DRUG: CBD 800 mg|DRUG: Control (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Manual Pressure and Shotblocker on Pain and Injection Satisfaction in Intramuscular Injection Application
Status: COMPLETED
Conditions: Intramuscular Injection
Interventions: DEVICE: Shotblocker|OTHER: Manual Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Trimodal Prehabilitation in Pancreatic Cancer Patients Urdergoing Neoadjuvant Treatment
Status: RECRUITING
Conditions: Pancreatic Neoplasms
Interventions: COMBINATION_PRODUCT: Trimodal prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Palmar Plantar Erythrodysesthesia (PPE) With Topical Sildenafil
Status: COMPLETED
Conditions: Hand Foot Syndrome|Palmar Plantar Erythrodysesthesia
Interventions: DRUG: sildenafil citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of a Salivary miRNA Diagnostic Test for ASD
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Developmental Delay
Interventions: OTHER: Salivary Collection|OTHER: Adaptive Assessment|OTHER: Medical and Demographic questionnaire|OTHER: Autism Assessment|OTHER: Intellectual Development Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Early Postoperative Day 0 Chest Tube Removal After Thoracoscopic Minor Surgeries
Status: RECRUITING
Conditions: Lung Pathologies of Unclear Etiology
Interventions: PROCEDURE: Early postoperative day 0 (POD 0) chest tube removal.|PROCEDURE: Chest tube removal according to traditional standard protocol not earlier than on postoperative day 1 (POD 1).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Duvelisib and Venetoclax in Relapsed or Refractory CLL or SLL or RS
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Richter Syndrome
Interventions: DRUG: Duvelisib|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: How Can Rehospitalisations of Patients With Schizophrenia be Avoided? A Comparison Between Different Compliance Programs
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: OTHER: Psychoeducation by professonals|OTHER: Psychoeducation by peer-moderators|OTHER: Video-education|OTHER: Noneducational video group (control group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Partnered Rhythmic Rehabilitation in Prodromal Alzheimer's Disease
Status: RECRUITING
Conditions: Prodromal Alzheimer's Disease
Interventions: OTHER: Partnered Rhythmic Rehabilitation (PRR)|OTHER: Group walking (WALK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bupivacaine Versus Bupivacaine Plus Lidocaine in Infraclavicular Block
Status: COMPLETED
Conditions: Pain, Acute|Postoperative Pain|Analgesia
Interventions: DRUG: Bupivacaine-Lidocaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pot-Kast: Thrombosis Prophylaxis After Knee Arthroscopy
Status: COMPLETED
Conditions: Deep Venous Thrombosis|Pulmonary Embolism
Interventions: DRUG: LMWH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of OsrHSA in Adult Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Ascites Hepatic
Interventions: DRUG: OsrHSA 20 mg/kg IV|DRUG: OsrHSA 40 mg/kg IV|DRUG: OsrHSA 80 mg/kg IV|DRUG: OsrHSA 140 mg/kg IV|DRUG: OsrHSA 200 mg/kg IV|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Endotype-Targeted Therapy to Rescue OSA Patients Struggling With CPAP Adherence (TOP-CPAP)
Status: RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: Eszopiclone 2 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fenofibrate and Metformin Fixed Combination vs Metformin - FAME METFO
Status: COMPLETED
Conditions: Dyslipidemia/Glucose Metabolism Disorder
Interventions: DRUG: fenofibrate (F) + metformin (M) hydrochloride fixed combination|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intraocular Lens-shell Technique in Phacoemulsification
Status: COMPLETED
Conditions: Cataract|Pseudoaphakia
Interventions: PROCEDURE: IOL-shell technique|PROCEDURE: Conventional procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of PRO-157 vs Moxifloxacin vs Gatifloxacin in Patients With Bacterial Conjunctivitis (Pazufloxacin)
Status: COMPLETED
Conditions: Bacterial Conjunctivitis
Interventions: DRUG: PRO-157|DRUG: Vigamox|DRUG: Zymar®|DRUG: Lagricel Ofteno®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pharmacokinetic and Pharmacodynamic Characteristics of Indobufen, an Anticoagulant Agent
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Indobufen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing a Modified Mini-incision Approach Versus the Conventional Approach for Carpal Tunnel Release
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome|Incision
Interventions: PROCEDURE: carpal tunnel release mini-incision|PROCEDURE: carpal tunnel release conventional incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Three Anticoagulation Strategies for Hemodialysis in Patients at Risk of Hemorrhage
Status: UNKNOWN
Conditions: Hemodialysis|Anticoagulation
Interventions: DRUG: two stage regional citrate|DRUG: one stage regional citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interaction Between Magnesium and Neostigmine or Sugammadex for the Reversal of a Rocuronium-induced Neuromuscular Block
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: DRUG: Magnesium Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Pharmacokinetics of Tricaprilin Formulations and a Placebo on Ketone Body Production
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Tricaprilin|DRUG: Tricaprilin|DRUG: Placebo|DRUG: Tricaprilin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Targeting Social Function to Improve Outcomes in Eating Disorders
Status: RECRUITING
Conditions: Eating Disorders|Anorexia Nervosa|Bulimia Nervosa|Atypical Anorexia Nervosa|Purging (Eating Disorders)|Other Specified Feeding or Eating Disorder
Interventions: BEHAVIORAL: Educational|BEHAVIORAL: Interactive
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Patients With Hepatitis C Virus Related Liver Cirrhosis After Sustained Response to Direct Acting Anti Viral Drugs.
Status: UNKNOWN
Conditions: Hepatitis C|Liver Cirrhosis
Interventions: DIAGNOSTIC_TEST: Abdominal ultrasound .|DIAGNOSTIC_TEST: Model for End-Stage Liver Disease|DIAGNOSTIC_TEST: Fibro Scan.|DIAGNOSTIC_TEST: Child-Turcotte-Pugh score.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Palliative Morphine With or Without Concurrent Modafinil
Status: UNKNOWN
Conditions: Cancer|Pain Palliation|Excessive Sleepiness
Interventions: DRUG: Modafinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Supporting Family Carers' Mental Health
Status: RECRUITING
Conditions: Feasibility
Interventions: BEHAVIORAL: Carers-ID online support programme|BEHAVIORAL: Carers-ID online support programme - Wait-list control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Biomarker Levels in Blood, Saliva and Gingival Fluid in Periodontitis
Status: UNKNOWN
Conditions: Periodontitis
Interventions: OTHER: No intervention was applied to the groups the samples will be collected in terms of the diagnosis (hopeless, periodontitis, gingivitis, healthy)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Pioglitazone on T2DM Patients With COVID-19
Status: UNKNOWN
Conditions: Covid19|Type 2 Diabetes
Interventions: DRUG: Pioglitazone 45 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Subjects With Onychomycosis of the Great Toenail
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: AN2690 Solution, 5.0%|DRUG: AN2690 Solution, 7.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Bone Marrow Concentrate and Iliac Cancellous Bone Graft in Alveolar Cleft Grafting
Status: COMPLETED
Conditions: Alveolar Cleft Grafting
Interventions: PROCEDURE: bone marrow concentrate alveolar cleft grafting|PROCEDURE: Autogenous alveolar grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Food Effect and DDI of Ascending Doses of the MEK Inhibitor Zapnometinib
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ATR-002|DRUG: Placebo|DRUG: Repaglinide|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Double-Blind Comparison of the Efficacy and Safety of C213 to Placebo for the Acute Treatment of Cluster Headaches
Status: COMPLETED
Conditions: Cluster Headache
Interventions: DRUG: C213 Microneedle System|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autonomic Effects of T4 Mobilization in Asymptomatic Subjects
Status: COMPLETED
Conditions: Other Disorders of the Autonomic Nervous System|Vertebra; Degeneration
Interventions: OTHER: Spinal mobilization|OTHER: Spinal Mobilization II|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of PulseNmore FC Device in Patients Undergoing IVF Treatment A Study to Evaluate the Safety and the Efficacy
Status: RECRUITING
Conditions: Women Undergoing Fertility Treatments
Interventions: DEVICE: PulseNmore FC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Folfirinox or Gemcitabine-Nab Paclitaxel Followed by Stereotactic Body Radiotherapy for Locally Advanced Pancreatic Cancer
Status: TERMINATED
Conditions: Locally Advanced Pancreatic Cancer|Borderline Pancreatic Inoperable Cancer|Pancreatic Cancer
Interventions: DRUG: Folfirinox|DRUG: Gemcitabine nab-Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel and Gemcitabine in Treating Patients With Progressive Regional or Metastatic Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter|Urethral Cancer
Interventions: DRUG: docetaxel|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of ARRY-520 and Bortezomib Plus Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma, Plasma Cell Leukemia
Interventions: DRUG: ARRY-520, KSP(Eg5) inhibitor; intravenous|DRUG: Bortezomib, proteasome inhibitor; intravenous or subcutaneous|DRUG: Dexamethasone, steroid; oral|DRUG: Filgrastim, granulocyte-colony stimulating factor (G-CSF); subcutaneous|DRUG: ARRY-520, KSP(Eg5) inhibitor; intravenous|DRUG: Bortezomib, proteasome inhibitor; intravenous or subcutaneous|DRUG: Filgrastim, granulocyte-colony stimulating factor (G-CSF); subcutaneous
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Events From Trifluridine/Tipiracil +/- Oxaliplatin in Colorectal/Oesogastric Adenocarcinoma Patients
Status: TERMINATED
Conditions: Colorectal Adenocarcinoma|Oesogastric
Interventions: DRUG: Trifluridine/Tipiracil|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Bioequivalence or Relative Bioavailability of Three New Idasanutlin Tablet Variants Following Oral Administration in Participants With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Idasanutlin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Home Environment and Development in Children Diagnosed With Muscular Torticollis
Status: COMPLETED
Conditions: Congenital Muscular Torticollis|Motor Development|Sensory Integration Disorder
Interventions: BEHAVIORAL: Affordances in the Home Environment for Motor Development-Infant Scale|BEHAVIORAL: Peabody Developmental Motor Scales-2|BEHAVIORAL: Test Of Sensory Functions In Infants (TSFI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate the Effectiveness of ABC+3TC +EFV in Once-Daily Regimens Versus KLT in Twice-Daily Regimens in Naive HIV Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Kivexa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Shock Wave Therapy Versus Low Level Lazer Therapy in Diabetic Frozen Shoulder Patients.
Status: RECRUITING
Conditions: Diabetes Complications
Interventions: RADIATION: Shock wave therapy|RADIATION: Low level lazer therapy|OTHER: Routine physical therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sleep Restriction on Metabolic Disturbances Caused by Overfeeding
Status: UNKNOWN
Conditions: Sleep
Interventions: DIETARY_SUPPLEMENT: Overfeeding (130 % of energy requirements )|BEHAVIORAL: Sleep restriction (4 hours per night)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Metformin and Probiotics on Gut Microbiome in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Metformin powder|DRUG: Probiotics powder|OTHER: Placebo powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Descemet Membrane Endothelial Keratoplasty vs. Descemet's Stripping With Endothelial Keratoplasty vs. Descemet Stripping Only
Status: TERMINATED
Conditions: Cystoid Macular Edema|Fuchs Dystrophy
Interventions: DIAGNOSTIC_TEST: Optical Coherence Tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neuromodulation and Cognitive Training in Opioid Use Disorder
Status: RECRUITING
Conditions: Opioid-use Disorder|Opioid Dependence|Opioid Abuse
Interventions: DEVICE: Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Neoadjuvant KRAS G12C Directed Therapy With Adagrasib (MRTX849) With or Without Nivolumab
Status: RECRUITING
Conditions: Resectable Non-Small Cell Lung Cancer
Interventions: DRUG: Adagrasib|COMBINATION_PRODUCT: Adagrasib/Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mupirocin-Iodophor ICU Decolonization Swap Out Trial
Status: COMPLETED
Conditions: Staphylococcus Aureus
Interventions: DRUG: Arm 1. Routine Care (Mupirocin/CHG)|DRUG: Arm 2. Iodophor/CHG Decolonization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pecha Kuka Method About Percutaneous Endoscopic Gastrostomy for Caregivers Who Care for Palliative Care Patients
Status: COMPLETED
Conditions: Pecha Kuka|Palliative Care
Interventions: BEHAVIORAL: Pecha Kucha
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Randomized Trial on Same-day SBRT and Surgical Stabilization for Symptomatic Spinal Metastases
Status: RECRUITING
Conditions: Spinal Metastases
Interventions: OTHER: Same-day SBRT and spinal surgery|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of CPC on Aborting Tilt Induced Syncope in Patients With a History of Vasovagal Syncope or Near Syncope
Status: COMPLETED
Conditions: Syncope, Vasovagal
Interventions: DRUG: CPC - Capsaicin, Phenylephrine, Caffeine|DIAGNOSTIC_TEST: Tilt Table Test|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3541105 in Healthy and Overweight Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Overweight|Healthy
Interventions: DRUG: LY3541105|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fentanyl Background Infusion for Acute Postoperative Pain
Status: COMPLETED
Conditions: Analgesia Disorder
Interventions: OTHER: FX2-2-2|OTHER: D6-4-2|OTHER: D8-4-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Alveolar Ridge Augmentation Following Tooth Extraction Using Bovine Xenograft With Platelet Rich Fibrin Membrane
Status: COMPLETED
Conditions: Bone Regeneration
Interventions: PROCEDURE: a bone graft mixed with PRF & covered by PRF membrane in fresh extraction socket
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study to Compare the Effects of Tenelia® or Januvia® on Glucose Variability in add-on to Metformin (CGMS Study)
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Teneligliptin|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial Comparing Irrisept Versus Normal Saline for Wound Irrigation After Posterior Spine Surgery
Status: WITHDRAWN
Conditions: Lumbar Spine Degeneration|Cervical Spine Degeneration
Interventions: DRUG: saline 0.9%|DRUG: (0.05% chlorhexidine gluconate (CHG) in sterile water)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: NOGO for an Overactive Bladder
Status: UNKNOWN
Conditions: Overactive Bladder|Nocturia
Interventions: DRUG: extract from Angelica archangelica leaf|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sorafenib in Treating Non-Smokers or Former Light Smokers With Relapsed or Refractory Stage IIIB or Stage IV Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DRUG: sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Effect of Liraglutide Versus Glimepiride (Amaryl®) on Haemoglobin A1c
Status: TERMINATED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: glimepiride|DRUG: liraglutide|DRUG: placebo|DRUG: placebo|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Avastin (Bevacizumab) in Patients With Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: Cisplatin|DRUG: Gemcitabine|DRUG: Placebo|DRUG: bevacizumab [Avastin]|DRUG: bevacizumab [Avastin]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcome Following Phacoemulsification Versus Small Incision Cataract Surgery (SICS)
Status: COMPLETED
Conditions: Visual Outcomes|Quality of Life
Interventions: PROCEDURE: phacoemulsification and SICS|PROCEDURE: manual small incision surgery|PROCEDURE: phacoemulsification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Basal-Bolus Closed-Loop Co-Administration of Insulin and Pramlintide on Improving the Glycemic Control in Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: OTHER: 24-hour inpatient intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of DEX-IN During Outpatient Procedures
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: DEX-IN|DRUG: Fentanyl|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postmenopausal Pessary Users: Estrogen Versus Trimosan
Status: TERMINATED
Conditions: Vaginosis|Vaginosis, Bacterial|Vaginal Discharge
Interventions: DRUG: Estrogen vaginal cream|DRUG: Trimo-San vaginal gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radical Hysterectomy Followed by Tailored Adjuvant Therapy Versus Primary Chemoradiation Therapy in Bulky Early-stage Cervical Cancer (KGOG 1029)
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: PROCEDURE: Radical hysterectomy|RADIATION: Tailored adjuvant therapy|RADIATION: Primary chemoradiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating The Potential Effect Of Multiple Doses Of Neratinib On The Pharmacokinetics Of A Single Dose Of Digoxin
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Digoxin|DRUG: Neratinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Procedural Pain in Children: Intervention With the Hospital Clown
Status: COMPLETED
Conditions: Pain, Acute|Venous Puncture|Children, Adult
Interventions: BEHAVIORAL: Hospital clown|BEHAVIORAL: No hospital clown intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluate Efficacy, Safety and Tolerability of AZD1656 as Add-on Treatment to Metformin in Type 2 Diabetes Mellitus (TD2M) Patients
Status: COMPLETED
Conditions: Type II Diabetes Mellitus
Interventions: DRUG: AZD1656|DRUG: Placebo|DRUG: Glipizide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Strategy For Personalized Long-Term Dual Antiplatelet Therapy (RAPID EXTEND PILOT STUDY)
Status: TERMINATED
Conditions: Stable Coronary Syndrome|Percutaneous Coronary Intervention|Antiplatelet Therapy|Ticagrelor
Interventions: DRUG: Ticagrelor 60mg|DRUG: Clopidogrel 75mg|DRUG: Aspirin 81 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Investigate the Efficacy of Bendamustine in Patients With Indolent Non-Hodgkin's Lymphoma (NHL) Refractory to Rituximab.
Status: TERMINATED
Conditions: Indolent B-cell NHL
Interventions: DRUG: Bendamustine IV|OTHER: Treatment of Physicians Choice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Tamsulosin in the Treatment of Ureteral Stones in Emergency Department Patients
Status: COMPLETED
Conditions: Kidney Stones|Ureteral Stones
Interventions: DRUG: Tamsulosin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tobacco Treatment Comparison for Cancer Care
Status: ENROLLING_BY_INVITATION
Conditions: Smoking Cessation|Cancer
Interventions: DRUG: Transdermal Nicotine Patch|BEHAVIORAL: Standard Telephone Counseling|DRUG: Varenicline|BEHAVIORAL: Cancer-Targeted Telephone Counseling|OTHER: Mailed Information about Standard Care Resources
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Deferasirox and Desferoxamine in Patients of β-Thalassemia Major With Iron Overload
Status: COMPLETED
Conditions: Pateints of β-thalassemia Major With Iron Overload
Interventions: DRUG: Deferasirox (DFX)|DRUG: Deferoxamine (DFO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT-evaluation of Retzius-sparing Robotic Prostatectomy
Status: UNKNOWN
Conditions: Prostate Cancer|Urinary Incontinence
Interventions: PROCEDURE: robotic Prostatectomy (RARP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Influence of MMP on Brain AVM Hemorrhage
Status: COMPLETED
Conditions: Arteriovenous Malformations|Cavernous Angiomas|Brain Aneurysms
Interventions: DRUG: Doxycycline or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Iloprost in Gas Exchange/Pulm Mechanics in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Pulmonary Hypertension
Interventions: DRUG: iloprost Inhalation|DRUG: iloprost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT