pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: BE WELL With Migraine: Brain Education and WELLness With Migraine
Status: RECRUITING
Conditions: Migraine
Interventions: BEHAVIORAL: Brain Education and WELLness with Migraine Group A|BEHAVIORAL: Brain Education and WELLness with Migraine Group B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetic Interactions Between Antiretroviral Agents and Antimalarial Drug Combinations
Status: COMPLETED
Conditions: HIV Infections|Malaria
Interventions: DRUG: lopinavir/ritonavir|DRUG: efavirenz|DRUG: artemether/lumefantrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Bioequivalence of Pramipexole Dihydrochloride Sustained Release Tablets
Status: TERMINATED
Conditions: Parkinson's Disease
Interventions: DRUG: Praxol hydrochloride sustained release tablet Specification: 0.375mg/ tablet (in pramipexole hydrochloride)|DRUG: Pramipexole hydrochloride sustained-release tablet (Siforl®) Specification: 0.26mg/ tablet (in pramipexole)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Role of Glucocorticoids to Maintain Energy Homeostasis During Starvation (Gluco-Starve)
Status: COMPLETED
Conditions: Glucocorticoid Effect
Interventions: DRUG: Metyrapone 250 mg Oral Tablets|DRUG: Hydrocortisone 19.9mg s.c., pulsatile with a flow rate of 10μl/s|DRUG: Placebo 250 mg Tablets|DRUG: Placebo (0,9% NaCl solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Remote Intervention in Patients With SCAD
Status: WITHDRAWN
Conditions: Stable Chronic Angina|Ischemic Heart Disease|Coronary Artery Disease|Heart Diseases|Myocardial Ischemia
Interventions: BEHAVIORAL: remote intervention|BEHAVIORAL: Routine outpatient follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 1/2 Study of MRTX0902 in Solid Tumors With Mutations in the KRAS MAPK Pathway
Status: RECRUITING
Conditions: Solid Tumor|Advanced Solid Tumor|Non Small Cell Lung Cancer|Colo-rectal Cancer
Interventions: DRUG: MRTX0902|DRUG: MRTX849
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of the Resection Rate for Hot and Cold Snare Polypectomy of Colorectal Polyps (5-15 mm)
Status: UNKNOWN
Conditions: Adenomatous Polyps
Interventions: PROCEDURE: Active Comparator: Hot Snare Polypectomy|PROCEDURE: Experimental: Cold Snare Polypectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Use of Adult Bone Marrow Mononuclear Cells in Patients With Long Bone Nonunion
Status: COMPLETED
Conditions: Long Bone Nonunion
Interventions: PROCEDURE: Osteosynthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Safety and Efficacy in Subjects With Chronic Cough
Status: COMPLETED
Conditions: Chronic Cough
Interventions: DRUG: ADX-629|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Two-dimensional Shear Wave Elastography for Assessment of Cirrhosis and Portal Hypertension
Status: NOT_YET_RECRUITING
Conditions: Cirrhosis, Liver|Portal Hypertension
Interventions: DIAGNOSTIC_TEST: Hepatic venous pressure gradient|DIAGNOSTIC_TEST: Two-Dimensional Shear Wave Elastography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mycophenolate Mofetil for Treatment of Relapses of Wegener's Disease or Microscopic Polyangiitis (MPA)
Status: COMPLETED
Conditions: Wegener's Granulomatosis|Vasculitis
Interventions: DRUG: mycophenolate mofetil|DRUG: cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peritransplant Ruxolitinib for Patients With Primary and Secondary Myelofibrosis
Status: RECRUITING
Conditions: Primary Myelofibrosis|Secondary Myelofibrosis
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Busulfan|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Melphalan|DRUG: Methotrexate|DRUG: Mycophenolate Mofetil|DRUG: Ruxolitinib|DRUG: Tacrolimus|RADIATION: Total-Body Irradiation|PROCEDURE: Computed Tomography|PROCEDURE: Echocardiography|PROCEDURE: Bone Marrow Aspiration and Biopsy|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Ultrasound Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effect in Children of Low-Dose Ketamine for Mucositis Treated by Patient-Controlled Analgesia With Morphine
Status: TERMINATED
Conditions: Cancer|Mucositis
Interventions: DRUG: Low dose ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of Kimchi Supplementation on Gut Microbiota, DNA Methylation and Serum Proteomes
Status: NOT_YET_RECRUITING
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Fermented Vegetables (Kimchi) supplementation|DIETARY_SUPPLEMENT: probiotic|DIETARY_SUPPLEMENT: polyphenol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: High-Dose Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Refractory Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: melphalan|DRUG: paclitaxel|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiological Investigation of Bile Duct Obstruction
Status: COMPLETED
Conditions: Gallstone Disease
Interventions: PROCEDURE: Cholecystectomy and intraoperative cholangiography|PROCEDURE: Magnet resonance cholangio-pancreaticography|DEVICE: magnet resonance imaging|DEVICE: catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase I Bioavailability and Pharmacokinetic Study of [14C]-Ipatasertib Single Oral and Intravenous Doses in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Period 1 treatment|DRUG: Period 2 treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Thiamine as an Adjunctive Therapy in Cardiac Surgery
Status: COMPLETED
Conditions: Coronary Artery Bypass|Cardiac Surgical Procedures
Interventions: DRUG: Thiamine|DRUG: Normal saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Venetoclax Combined With CACAG Regimen in the Treatment of Newly Diagnosed Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: azacytidine;cytarabine;aclamycin;Chidamide;venetoclax;granulocyte
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of an Investigational Drug Sitagliptin for Type 2 Diabetes Mellitus (0431-044)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: sitagliptin phosphate|DRUG: Comparator: placebo (unspecified)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of CAP1-6D in Patients With Locally Advanced or Surgically Resected Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma
Interventions: BIOLOGICAL: modified CEA peptide (10mcg)|BIOLOGICAL: modified CEA peptide (100mcg)|BIOLOGICAL: modified CEA peptide (1000mcg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of the Effect of Low Level Laser Therapy on Diabetic Peripheral Neuropathy Pain
Status: TERMINATED
Conditions: Diabetic Peripheral Neuropathy
Interventions: DEVICE: Erchonia FX-635|DEVICE: Placebo Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluorescence Image Guided Surgery in Cholangiocarcinoma
Status: UNKNOWN
Conditions: Hilar Cholangiocarcinoma
Interventions: DRUG: Bevacizumab-IRDye800CW|DEVICE: near infrared (NIR) fluorescence imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Single-dose Crossover Study to Evaluate the Early Bronchodilating Effect of FlutiForm HFA pMDI in Adult Subjects With Mild to Moderate Asthma
Status: COMPLETED
Conditions: Mild to Moderate Asthma
Interventions: DRUG: fluticasone propionate, formoterol fumarate|OTHER: fluticasone propionate, formoterol fumarate|OTHER: fluticasone propionate, formoterol fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Pseudo-PDT in Central Serous Chorioretinopathy
Status: UNKNOWN
Conditions: Chronic Central Serous Chorioretinopathy
Interventions: PROCEDURE: 689 nm Laser Treatment of the Macula|PROCEDURE: Half Dose Photodynamic Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment for Patients Suffering From Anemia Due to Chemotherapy
Status: COMPLETED
Conditions: Breast Cancer|Anemia
Interventions: DRUG: Darbepoetin Alfa|DRUG: Recombinant Human Erythropoietin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influenza Virus Vaccine Plus Vitamin A and D Supplements for Prevention of Respiratory Virus Infections in Children
Status: COMPLETED
Conditions: Healthy Participants
Interventions: BIOLOGICAL: Influenza virus vaccine|DIETARY_SUPPLEMENT: Vitamins A and D|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Selection of Aspheric Diffractive Multifocal Intraocular Lens (IOLS) Based on Corneal Wavefront
Status: COMPLETED
Conditions: Cataracts
Interventions: DEVICE: Tecnis® Multifocal (TMF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD19 Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy in Treating Patients With B-cell Malignancies
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia|B Cell Lymphoma
Interventions: GENETIC: Second generation CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-Invasive Diagnosis of Pulmonary Vascular Disease Using Inhaled 129Xe Magnetic Resonance Imaging
Status: COMPLETED
Conditions: Pulmonary Vascular Disease
Interventions: DRUG: GE-141, Hyperpolarized 129Xenon gas|DEVICE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Personalized Chimeric Antigen Receptor T Cell Immunotherapy for Patients With Recurrent Malignant Gliomas
Status: UNKNOWN
Conditions: Glioma|Malignant Glioma of Brain|Recurrence Tumor
Interventions: BIOLOGICAL: chimeric antigen receptor T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mass Balance and Pharmacokinetics Study of Derazantinib in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Derazantinib capsule|DRUG: [14C]-Derazantinib solution for infusion|DRUG: [14C]-Derazantinib capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Intra-abdominal Pressure to the Level of the Sensory Block at Caesarean Section Under Spinal Anesthesia
Status: COMPLETED
Conditions: Obstetric Anesthesia Problems|High-Risk Pregnancy
Interventions: PROCEDURE: Measurement of IAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immediate Vs. Early Loading of Immediately Placed Implants
Status: COMPLETED
Conditions: Implant Complication|Implant
Interventions: DEVICE: Immediate implant loading|DEVICE: Early implant loading
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Recombinant Human Growth Hormone in Children With Achondroplasia
Status: RECRUITING
Conditions: Achondroplasia
Interventions: DRUG: Recombinant human growth hormone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Best Promising Drug Association With Azacitidine in Higher Risk Myelodysplastic Syndromes
Status: UNKNOWN
Conditions: MDS
Interventions: DRUG: Azacitidine|DRUG: Azacitidine associated with Valproic acid|DRUG: Azacitidine associated with Lenalidomide|DRUG: Azacitidine associated with Idarubicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Pre-emptive Intravenous Immunoglobulin (IVIG) on the Incidence of Septic Episodes in Pediatric Burn Patients
Status: COMPLETED
Conditions: Burn Shock
Interventions: DRUG: intravenous immunoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Drug-drug Interaction Trial With Tralokinumab in Moderate to Severe Atopic Dermatitis - ECZTRA 4
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Tralokinumab|DRUG: Caffeine|DRUG: Warfarin|DRUG: Omeprazole|DRUG: Metoprolol|DRUG: Midazolam Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Bupivacaine and Transoral Robotic Surgery
Status: RECRUITING
Conditions: Oropharyngeal Cancer|Dysphagia, Oropharyngeal|Post Operative Pain|Transoral Robotic Surgery
Interventions: DRUG: Liposomal bupivacaine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Home Telehealth Follow-up After Hospital Discharge for Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: PROCEDURE: Home telehealth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Metanx Effects on Nerve Fiber Density in Neuropathic Diabetics
Status: UNKNOWN
Conditions: Diabetes|Peripheral Neuropathy
Interventions: DIETARY_SUPPLEMENT: Metanx|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Home Based Tel-Exercise on Dialysis Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: End Stage Renal Disease|Hemodialysis Complication
Interventions: BEHAVIORAL: Home based Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Interventions on Non-prescription Dispensing of Antibiotics in Community Pharmacies
Status: ENROLLING_BY_INVITATION
Conditions: Non-Prescription Drug Misuse|Acute Respiratory Tract Infection
Interventions: BEHAVIORAL: social surveillance and health education interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Traditional Tibetan Medicine for Patients With Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: BEHAVIORAL: Nutritional and behavioral program A|BEHAVIORAL: Nutritional and behavioral program B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Endotracheal Cuff Pressure Control to Prevent Ventilator Associated Respiratory Infections
Status: COMPLETED
Conditions: Mechanical Ventilation Complication|Tracheal Intubation Morbidity|Ventilator-Associated Pneumonia|Hospital Acquired Infection
Interventions: DEVICE: Tracoe cuff pressure controller
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Open-Label and Long-Term Extension Study to Evaluate the Efficacy and Safety of Ustekinumab in the Treatment of Patients With Ichthyoses
Status: COMPLETED
Conditions: Ichthyosis
Interventions: DRUG: Ustekinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 4 Fluticasone Furoate Nasal Spray (VERAMYST) Long Term Pediatric Growth Study.
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial
Interventions: DRUG: Fluticasone furoate nasal spray|DRUG: Placebo nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Leucine Metabolites in Performance, Body Composition and Biochemical Markers of Muscle Damage
Status: COMPLETED
Conditions: Resistance Training
Interventions: DIETARY_SUPPLEMENT: HMB-FA|DIETARY_SUPPLEMENT: HMB-Ca|DIETARY_SUPPLEMENT: alfa-HICA|OTHER: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Zimberelimab Combined With Concurrent Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer
Status: RECRUITING
Conditions: Locally Advanced Cervical Cancer
Interventions: DRUG: zimberelimab combined With concurrent radiotherapy and chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DaxibotulinimtoxinA for Treatment of Platysmal Neck Bands
Status: RECRUITING
Conditions: Aging
Interventions: DRUG: DaxibotulinumtoxinA 15 units|DRUG: DaxibotulinumtoxinA 20 units
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Acthar Gel for Inflammation of the Eye's Uvea (Middle Layer)
Status: TERMINATED
Conditions: Uveitis, Posterior|Uveitis, Intermediate|Panuveitis
Interventions: DRUG: Acthar Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Utilizing Ultrasound for Residents as an Aid in Epidural Placement
Status: WITHDRAWN
Conditions: Epidural Placement
Interventions: DEVICE: Ultrasound Guided Epidural|PROCEDURE: Standard Epidural
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Assessment of Hepatic Fibrosis by Shear Wave Elastography in Patients With Liver Malignancy: A Prospective Single-center Study
Status: COMPLETED
Conditions: Liver Tumor|Hepatic Fibrosis
Interventions: OTHER: two-dimensional shear-wave elastography (SWE)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Tolerability of Liraglutide in Healthy Japanese Male Volunteers
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: liraglutide|DRUG: liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Vagus Nerve Stimulation for Treatment of Refractory Epilepsy
Status: UNKNOWN
Conditions: Refractory Epilepsy
Interventions: DEVICE: Vagus Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Standing on Glycemia in Prediabetic Adults
Status: COMPLETED
Conditions: Prediabetes
Interventions: OTHER: Sitting OGTT|OTHER: Standing OGTT|OTHER: Sitting CGM|OTHER: Standing CGM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Trial of Ultrashort Psychotherapy vs Sustained-Release Bupropion for Smoking Cessation
Status: COMPLETED
Conditions: Nicotine Dependence|Substance Abuse|Substance Dependence|Tobacco Dependence
Interventions: DRUG: sustained-release bupropion (Zyban(R))|BEHAVIORAL: Psychodynamic Model Training (R) = PDM(R)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bougie Versus Endotracheal Tube Alone on First-attempt Intubation Success in Prehospital Emergency Intubation (BETA Trial)
Status: RECRUITING
Conditions: Acute Respiratory Failure Requiring Intubation
Interventions: PROCEDURE: First intubation attempt with endotracheal tube plus bougie|PROCEDURE: First intubation attempt with endotracheal tube alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fundación IVO Registry for Patients Undergoing Sling or Artificial Urinary Sphincter After Prostate Cancer Treatment
Status: RECRUITING
Conditions: Urinary Incontinence, Stress
Interventions: PROCEDURE: AMS-800|PROCEDURE: ADVANCE/ADVANCEXP|PROCEDURE: VIRTUE|PROCEDURE: INVANCE
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: HCMV Breakthrough Infections During Letermovir Prophylaxis
Status: RECRUITING
Conditions: Cytomegalovirus Infections|Cytomegalovirus Viremia|Hematopoietic Stem Cell Transplantation
Interventions: DIAGNOSTIC_TEST: Determination of HCMV DNA in plasma after DNAse digestion.|DIAGNOSTIC_TEST: Determination of HCMV DNA in blood or plasma.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Multicenter Trial Evaluating Quality of Tears Produced by Nasal Neurostimulation
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DEVICE: Oculeve Intranasal Lacrimal Neurostimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: MSCs With or Without Peripheral Blood Stem Cell for Treatment of Poor Graft Function and Delayed Platelet Engraftment
Status: UNKNOWN
Conditions: Stem Cell Transplantation, Hematopoietic|Poor Graft Function|Delayed Platelet Engraftment|Hematological Diseases
Interventions: BIOLOGICAL: PBSC|BIOLOGICAL: MSCs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Combination Therapy: Montelukast and Inhaled Steroid on Exercise Induced Bronchoconstriction
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: budesonide|DRUG: montelukast|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Kidney Function for Drug Dosage Adjustments in Critically Ill Patients
Status: UNKNOWN
Conditions: ICU Patients
Interventions: DIAGNOSTIC_TEST: kidney function assessment by 4 hour creatinine clearance|DIAGNOSTIC_TEST: kidney function assessment by creatinine based eGFR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Bone Marrow Transplantation in Treating Patients With Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: c-myb antisense oligonucleotide G4460|BIOLOGICAL: filgrastim|DRUG: busulfan|DRUG: cyclophosphamide|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: in vitro-treated bone marrow transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy of Antioxidant Therapy Compared With Enalapril in Sickle Nephropathy
Status: UNKNOWN
Conditions: Microalbuminuria|Sickle Cell Nephropathy
Interventions: DRUG: Enalapril|DRUG: N-Acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Trial of RPC1063 for Moderate to Severe Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: RPC1063|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Different Training (Aerobic, Resistance or Mixed) Physical Programs Affect to Physiological Responses (TRAINING2014)
Status: COMPLETED
Conditions: Health Behavior
Interventions: OTHER: Training resistance|OTHER: Training aerobic|OTHER: Training resistance+aerobic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Compare Antimicrobial to Conventional Suture in Patients Receiving Primary Total Knee Replacement
Status: COMPLETED
Conditions: Wound Infection
Interventions: DEVICE: vicryl|DEVICE: Vicryl plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Attention Training for Underserved Youth With Anxiety
Status: COMPLETED
Conditions: Anxiety
Interventions: BEHAVIORAL: Attention Modification Program|BEHAVIORAL: Attention Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatments of Migraine With Triptans in Individuals With Elevated Cardiovascular Risk and in Pregnant Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Migraine|Cardiovascular Diseases|Pregnancy
Interventions: DRUG: Acute migraine treatment with any prescribed triptans|DRUG: Standard of care management of acute migraine without triptans
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Decreasing Dosing Regimens of Abiraterone 500 mg in Men With Prostate Cancer to Find Lowest Recommended Dose.
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer|Prostate Adenocarcinoma|Prostate Neoplasm|Prostate Cancer Metastatic
Interventions: DRUG: Abiraterone Oral Tablet|DRUG: Prednisone tablet|OTHER: Drug Dairy/Log|DRUG: Low-fat meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Anti-B7-H3 CAR-T Cell Therapy for Recurrent Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma
Interventions: BIOLOGICAL: B7-H3-targeting CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and a Donor Natural Killer Cell Infusion in Treating Patients With Relapsed or Persistent Leukemia or Myelodysplastic Syndrome After a Donor Stem Cell Transplant
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: natural killer cell therapy|DRUG: cyclophosphamide|DRUG: fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SeriACL™ Device (Gen IB) Trial for Anterior Cruciate Ligament (ACL) Repair
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Reconstruction
Interventions: DEVICE: SeriACL Device ACL Reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Two-Part Infant Study for Early Diagnosis of Respiratory Syncytial Virus (RSV) and Evaluation of JNJ-53718678 in RSV Acute Respiratory Tract Disease
Status: COMPLETED
Conditions: Respiratory Syncytial Viruses
Interventions: OTHER: RSV Mobile Application|DRUG: Placebo|DRUG: JNJ-53718678 2.5 mg/kg|DRUG: JNJ-53718678 3 mg/kg|DRUG: JNJ-53718678 4.5 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Group Motivational Intervention in Overweight/Obese Patients.
Status: UNKNOWN
Conditions: Overweight|Obesity
Interventions: BEHAVIORAL: Behavioral (e.g., Psychotherapy, Lifestyle Counseling)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Farxiga on Renal Function and Size in Type 2 Diabetic Patients With Hyperfiltration
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Dapagliflozin|DRUG: Metformin|DRUG: Glipizide 5 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation of Group Problem Management Plus (PM+) in Adult Syrian Refugees in Turkey: RCT (STRENGTHS)
Status: COMPLETED
Conditions: Anxiety|Depression|Posttraumatic Stress Disorder|Psychological Distress
Interventions: BEHAVIORAL: Problem Management Plus (PM+)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Remifentanil as a Sole Agent or in Combination With Midazolam Versus Fentanyl/Midazolam During Sedation for Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: Midazolam, Fentanyl|DRUG: Midazolam, Remifentanil|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Single-dose Steroid Application for the Treatment of Nausea and Vomiting After Thyroid Surgery
Status: COMPLETED
Conditions: Thyroidectomy|Thyroid Diseases
Interventions: DRUG: Dexamethasone|OTHER: NaCl 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Bioavailability of Diosmin/Hesperidin (90/10) 500 mg Tablets With Regards to Reference Product
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Diosmin/Hesperidin (90/10) 500 mg Test Drug|DRUG: Diosmin/Hesperidin (90/10) 500 mg Reference Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Linezolid Pharmacokinetics (PK) in Multi-Drug Resistant (MDR)/Extensively-Drug Resistant (XDR) Tuberculosis (TB)
Status: COMPLETED
Conditions: Multi-Drug Resistant Tuberculosis|Extensively Drug Resistant Tuberculosis
Interventions: DRUG: Linezolid|DRUG: Microcrystalline Methylcellulose - Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Longitudinal Surveillance of Rectal Colonization and Transmission by Resistant Bacteria in Acutely Decompensated Cirrhosis
Status: NOT_YET_RECRUITING
Conditions: Cirrhosis, Liver|Rectal Colonization|Multidrug Resistance Organisms
Interventions: OTHER: No intervention in this study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: NAVISTAR® THERMOCOOL® Catheter Post Approval Registry
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: PROCEDURE: Atrial fibrillation ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Safety and Efficacy of Intravenous Iron Versus Oral Iron in Subjects Who Display Postpartum Anemia
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Oral iron tablets|DRUG: VIT-45
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of the Nordic Sensi Chair in the Treatment of Dementia Behavioral Disorders (NSC-DEMEN)
Status: COMPLETED
Conditions: Dementia
Interventions: DEVICE: Nordic Sensi Chair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Type 2 Diabetes Pharmacotherapy Regimens
Status: RECRUITING
Conditions: Type 2 Diabetes Mellitus|Cardiovascular Diseases
Interventions: DRUG: SU|DRUG: DPP4|DRUG: SGLT2i|DRUG: GLP-1RA|DRUG: SGLT2i or GLP-1RA|DRUG: Linagliptin (DPP4)|DRUG: Exenatide (GLP-1RA)|DRUG: Liraglutide (GLP-1RA)|DRUG: Empagliflozin (SGLT2i)|DRUG: Glimepiride (SU)|DRUG: Glipizide (SU)|DRUG: Glimepiride (SU) or Glipizide (SU)|DRUG: SU or DPP4 (excluding saxagliptin and alogliptin)|DRUG: Exenatide (GLP-1RA) or Liraglutide (GLP-1RA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Dr. Pyke's Supplement for Stream (S4S) in Men With Prostatism and ED
Status: WITHDRAWN
Conditions: Prostatism|Erectile Dysfunction
Interventions: DIETARY_SUPPLEMENT: Dr. Pyke's Supplement for Stream (S4S)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Methylprednisolone on Immune Signaling in Hip-arthroplasty Patients
Status: COMPLETED
Conditions: Osteoarthrosis
Interventions: DRUG: Methylprednisolone|DRUG: Isotonic Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Comparison of Two Different Types of "Spray as You go" Technique for Awake Fiberoptic Intubation
Status: COMPLETED
Conditions: Awake Fiberoptic Intubation
Interventions: DEVICE: bronchoscope|DEVICE: Enk Fiberoptic Atomizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Lymphocyte Anti-metabolite Immunosuppressions on Donor-Specific Anti-HLA Antibody and Kidney Graft Outcome
Status: COMPLETED
Conditions: Kidney Transplant
Interventions: DRUG: Mycophenolate mofetil 500mg Tab. or 250mg Cap.|DRUG: Tacrolimus|DRUG: Methylprednisolone/prednisolone|DRUG: Basiliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Topical Diclofenac Combined With Oral Diclofenac in the Treatment of Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Diclofenac, topical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study
Status: RECRUITING
Conditions: Acute Spinal Cord Injury|Acute Spinal Paralysis|Spinal Cord Injuries|SPINAL Fracture
Interventions: PROCEDURE: SCPP Management => 65 mmHg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monitoring Epstein-Barr Virus (EBV) Load in Rheumatoid Arthritis Patients Treated With New Immunosuppressive Drugs
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Venous blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Extension and Crossover Vaccination Study on the Immune Response and Safety of a Vaccine Against Respiratory Syncytial Virus Given to Adults 60 Years of Age and Above Who Participated in RSV OA=ADJ-006 Study
Status: RECRUITING
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: RSVPreF3 OA vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phrenic Nerve Stimulation-Induced Lung ReAeration Trial
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome|Ventilation Therapy; Complications
Interventions: DEVICE: Lungpacer PROTECT Diaphragm Pacing Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dose Cytarabine Followed by Pembrolizumab in Relapsed/Refractory AML
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia, in Relapse
Interventions: DRUG: pembrolizumab,
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estrogen and Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DIETARY_SUPPLEMENT: Antioxidant Cocktail|DIETARY_SUPPLEMENT: Resveratrol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CTOP/ITE/MTX Compared With CHOP as the First-line Therapy for Newly Diagnosed Young Patients With T Cell Lymphoma
Status: UNKNOWN
Conditions: ALK-negative Anaplastic Large Cell Lymphoma|Peripherial T Cell Lymphoma,Not Otherwise Specified|Angioimmunoblastic T Cell Lymphoma|Enteropathy Associated T Cell Lymphoma|Hepatosplenic T Cell Lymphoma|Subcutaneous Panniculitis Like T Cell Lymphoma
Interventions: DRUG: Cyclophosphamide 750mg/m2|DRUG: Vincristine 1.4mg/m2|DRUG: Doxorubicin 50mg/m2|DRUG: prednisone 60mg/m2|DRUG: ifosfamide 2000mg/m2|DRUG: pirarubicin 50mg/m2|DRUG: pirarubicin 25mg/m2|DRUG: Etoposide phosphate 100mg/m2|DRUG: methotrexate 1500mg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Value of Renal Vascular Doppler Sonography in Management of Decompensated Heart Failure
Status: COMPLETED
Conditions: Cardiorenal Syndrome
Interventions: DRUG: intravenous furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: 3D OPTIMIZED WMN MPRAGE Increased Detection of Focal Spinal Cord Lesion in Multiple Sclerosis (WHINUME)
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DEVICE: 3D OPTIMIZED WMN MPRAGE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Using Non-invasive Brain Stimulation (tDCS) With Varenicline for Treating Tobacco Dependence
Status: COMPLETED
Conditions: Tobacco Dependence|Smoking Cessation|Tobacco Smoking|Tobacco Use Disorder|Substance Use Disorders|Molecular Mechanisms of Pharmacological Action|Physiological Effects of Drugs
Interventions: DRUG: Varenicline|DEVICE: Active tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Hydroxycholoroquine Compared to Placebo as Treatment for People With COVID-19
Status: WITHDRAWN
Conditions: COVID-19|COVID19|Sars-CoV2|SARS-Cov-2
Interventions: DRUG: Hydroxychloroquine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Surgical Outcomes of Total Thyroidectomy in Basedow's Disease: the Effect of Lugol Solution
Status: ENROLLING_BY_INVITATION
Conditions: Basedow Disease
Interventions: OTHER: Lugol -
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
Status: RECRUITING
Conditions: Dravet Syndrome
Interventions: DRUG: ETX101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Beta-Blocker Heart Attack Trial (BHAT)
Status: COMPLETED
Conditions: Arrhythmia|Cardiovascular Diseases|Coronary Disease|Death, Sudden, Cardiac|Heart Diseases|Myocardial Infarction|Myocardial Ischemia|Ventricular Fibrillation
Interventions: DRUG: propranolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Protein and Skeletal Muscle in Older Twins: Role of the Gut Microbiome
Status: COMPLETED
Conditions: Sarcopenia|Frailty|Age-Related Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Prebiotic food supplement|DIETARY_SUPPLEMENT: Protein supplement|DIETARY_SUPPLEMENT: Maltrodextrin (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Yuva Sath: A Peer-led Behavioral Intervention to Support Substance Use Treatment and HIV Prevention Among Young People Who Inject Drugs in India
Status: NOT_YET_RECRUITING
Conditions: Hiv|Substance Use Disorders
Interventions: BEHAVIORAL: Yuva Sath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Ceftazidime-Avibactam Versus Meropenem in Hospitalized Adults With Nosocomial Pneumonia
Status: COMPLETED
Conditions: Nosocomial Pneumonia (NP)|Ventilator-associated Pneumonia (VAP)
Interventions: DRUG: ceftazidim-avibactam (CAZ-AVI, experimental product)|DRUG: meropenem (active comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn More About How Much of the Study Treatment Elinzanetant (or BAY3427080) Gets Absorbed, How Safe it is and How it Affects the Body in Healthy Female and Male Participants
Status: COMPLETED
Conditions: Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men|Hot Flashes|Healthy Volunteers
Interventions: DRUG: Elinzanetant (BAY3427080)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Anti-MART-1 F5 Lymphocytes to Treat High-Risk Melanoma Patients
Status: TERMINATED
Conditions: Melanoma
Interventions: BIOLOGICAL: ALVAC-MART-1 vaccine|BIOLOGICAL: MART-1:26-35(27L) peptide vaccine|BIOLOGICAL: Aldesleukin|BIOLOGICAL: autologous anti-MART-1 F5 T-cell receptor gene-engineered peripheral blood lymphocytes|BIOLOGICAL: incomplete Freund's adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CHOICE: CHanges to Treatment and Outcomes in Patients With Type 2 Diabetes Initiating InjeCtablE Therapy
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: exenatide|DRUG: any human insulin or analog insulin(s) given in any regimen by subcutaneous injection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lung Ultrasound-guided Fluid Therapy in Pediatric Intensive Care Unit Patients
Status: RECRUITING
Conditions: Fluid Overload Pulmonary Edema|Fluid Overload|Pneumonia, Ventilator-Associated|Fluid Overload Without Edema
Interventions: DIAGNOSTIC_TEST: Pulmonary ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Patient Satisfaction and Oral Health-related Quality of Life (OHRQL) For Two Pick-up Techniques
Status: COMPLETED
Conditions: Prosthesis User
Interventions: PROCEDURE: implant supported mandibular overdenture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine in Serratus Plane Block for Mastectomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Bupivacaine-Dexmedetomidine|DRUG: Bupivacaine|DRUG: General anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE