pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Efficacy and Safety of AMG 334 in Adult Episodic Migraine Patients
Status: COMPLETED
Conditions: Episodic Migraine
Interventions: BIOLOGICAL: Erenumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Drug Use Surveillance for Brentuximab Vedotin Intravenous Infusion "Untreated CD30-Positive Hodgkin's Lymphoma"
Status: COMPLETED
Conditions: Untreated CD30-Positive Hodgkin's Lymphoma
Interventions: DRUG: Brentuximab vedotin (Genetical Recombination)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial on Three Eating Disorders Group Treatment
Status: UNKNOWN
Conditions: Eating Disorders
Interventions: OTHER: Arm 1: Cognitive-dissonance based program|OTHER: Arm 2: Mindfulness-based program|OTHER: Arm 3: Person-centered program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Evaluation of IM83 CAR-T Cells for Patients With Advanced Liver Tumors
Status: UNKNOWN
Conditions: Liver Cancer
Interventions: BIOLOGICAL: IM83 CAR-T cells|COMBINATION_PRODUCT: The second-line treatment of liver cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuroplasticity in an Extended Amygdala Network as a Target Mechanism for Attention Bias Modification Outcome
Status: COMPLETED
Conditions: Anxiety
Interventions: BEHAVIORAL: Attention Bias Modification|BEHAVIORAL: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of SCT650C in Participants With Axial Spondyloarthritis
Status: NOT_YET_RECRUITING
Conditions: Axial Spondyloarthritis
Interventions: DRUG: SCT650C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Davallia Divaricata BL: The Use of Traditional Chinese Native Medicine for Osteoporosis
Status: UNKNOWN
Conditions: Osteoporosis
Interventions: DRUG: Gu-Sui-Bu (Davallia Divaricata)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Mediterranean Diet Versus Western Diet on Fatigue in Autoimmune Hepatitis Patients
Status: RECRUITING
Conditions: Autoimmune Hepatitis
Interventions: DIETARY_SUPPLEMENT: Dietary assignment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tranexamic Acid in Dacryocystorhinostomy
Status: UNKNOWN
Conditions: Nasolacrimal Tract Obstruction
Interventions: DRUG: Tranexamic acid|DRUG: saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Regorafenib Plus Sintilimab vs. Regorafenib as the Second-line Treatment for HCC
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma Non-resectable
Interventions: DRUG: Regorafenib + sintilimab|DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Probiotic Supplementation on General Well Being
Status: NOT_YET_RECRUITING
Conditions: Well-Being, Psychological
Interventions: DIETARY_SUPPLEMENT: Lab4P|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TAK-438 Bismuth Drug Interaction Study
Status: COMPLETED
Conditions: Helicobacter Pylori
Interventions: DRUG: Clarithromycin|DRUG: Amoxicillin|DRUG: Tripotassium bismuth dicitrate|DRUG: Lansoprazole|DRUG: TAK-438
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Activating Older People After a Hip Fracture
Status: UNKNOWN
Conditions: Hip Fractures
Interventions: BEHAVIORAL: ActiveHip+ mobile application|PROCEDURE: Standard care in a hip fracture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IL-1RA, Acute Exercise, and Beta-cell Function
Status: WITHDRAWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Anakinra (AN)|BEHAVIORAL: Exercise (EX)|BEHAVIORAL: Control (CON)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nesiritide and Renal Function After the Total Artificial Heart
Status: TERMINATED
Conditions: Congestive Heart Failure|Cardiorenal Syndrome
Interventions: DRUG: nesiritide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Angiotensin Converting Enzyme and Sacubitril Valsartan in Patients After Bone Marrow Transplantation
Status: UNKNOWN
Conditions: Hematopoietic Stem Cell Transplantation|Cardiotoxicity
Interventions: DRUG: ACE inhibitor, Sacubitril-Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Warming Sensation Intensity and Acceptability of the Flavour, Local Tolerability of Paracetamol 500 mg + Phenylephrine 10mg + Guaifenesin 200 mg Syrup in Patients Suffering a Upper Respiratory Tract Infection (URTI)
Status: COMPLETED
Conditions: Upper Respiratory Infections
Interventions: DRUG: IFF flavor 316 282, Paracetamol , Phenylephrine, Guaifenesin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Impact of v Release on Dysphagia in Patients With Traumatic Brain Injury
Status: NOT_YET_RECRUITING
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: Rehabilitation treatment|BEHAVIORAL: Myofascial Release Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electroacupuncture Treatment of Behavioral and Psycological Symptoms in Patients With Alzheimer's Disease
Status: NOT_YET_RECRUITING
Conditions: BPSD (Behavioral and Psycological Symptoms of Dementia)|Alzheimer's Dementia
Interventions: OTHER: Electroacupuncture treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: GORE® VIABIL® Biliary Endoprosthesis in the Treatment of Benign Biliary Strictures Secondary to Chronic Pancreatitis
Status: SUSPENDED
Conditions: Pancreatitis, Chronic|Stricture; Bile Duct
Interventions: DEVICE: GORE® VIABIL® Biliary Endoprosthesis|DEVICE: GORE® VIABIL® Short Wire Biliary Endoprosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TBTC Study 27: Moxifloxacin vs Ethambutol for TB Treatment
Status: COMPLETED
Conditions: Tuberculosis, Pulmonary
Interventions: DRUG: moxifloxacin (with isoniazid, rifampin, pyrazinamide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis (IPF)
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Pirfenidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Immunize Patients With Extensive Stage SCLC Combined With Chemo With or Without All Trans Retinoic Acid
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Paclitaxel|BIOLOGICAL: Drug: Ad.p53-DC vaccines|DRUG: All -trans Retinoic Acid (ATRA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Gefitinib for Brain Metastasis of Non-Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-Small Cell Lung Cancer|Brain Metastasis
Interventions: DRUG: gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindfulness Breath Awareness Meditation and Preeclampsia
Status: RECRUITING
Conditions: Mindfulness Breath Awareness Meditation|Preeclampsia
Interventions: BEHAVIORAL: Mindfulness breath awareness meditation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Smoking Cessation Pilot for People Living With HIV (PLWH)
Status: COMPLETED
Conditions: Smoking Cessation|Smoking|Smoking Behaviors|Smoking Reduction|Smoking, Tobacco|Smoking, Cigarette|Hiv|HIV/AIDS
Interventions: DEVICE: Lumme mobile phone application|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Central Nervous System Vascular Changes in Adult Sickle Cell Disease and the Effect of Treatment With Simvastatin
Status: UNKNOWN
Conditions: Sickle Cell Disease|Stroke
Interventions: DRUG: Simvastatin 40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ELACESTRANT in Women and Men With CDK4/6 Inhibitor-Naive Estrogen Receptor Positive, HER-2 Negative Metastatic Breast Cancer Study
Status: RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Elacestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FX-322 in Adults With Age-Related Sensorineural Hearing Loss
Status: COMPLETED
Conditions: Presbycusis|Hearing Loss, Sensorineural|Noise Induced Hearing Loss|Sudden Hearing Loss
Interventions: DRUG: FX-322|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Energy Intake and Exercise Timing
Status: COMPLETED
Conditions: Pediatric Obesity
Interventions: OTHER: CON . control condition without exercise / rest condition|OTHER: EX -30. Condition with an acute exercise set 30 minutes before lunch|OTHER: EX-180. condition with an acute exercise set 180 minutes before lunch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Etirinotecan Pegol (NKTR-102) in NSCLC
Status: COMPLETED
Conditions: Metastatic Non Small Cell Lung Cancer|Recurrent Non Small Cell Lung Cancer
Interventions: DRUG: Etirinotecan pegol (NKTR-102)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Correlation Between Serum Levels of Adropin and Degree of Severity of Chronic Liver Disease
Status: UNKNOWN
Conditions: Chronic Liver Disease and Cirrhosis
Interventions: DIAGNOSTIC_TEST: Blood test for serum Adropin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Poised for Parkinson's - an Intervention to Increase Embodied Agency in People With Parkinson's Disease and Their Carers
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: BEHAVIORAL: Poised for Parkinson's
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sustained Release Oral Formulation for Treatment of Parkinson's Disease
Status: SUSPENDED
Conditions: Idiopathic Parkinson Disease
Interventions: DRUG: levodopa/carbidopa oral formulation A|DRUG: levodopa/carbidopa oral formulation B|DRUG: levodopa/carbidopa oral formulation C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ofatumumab With or Without Bendamustine for Patients With Mantle Cell Lymphoma Ineligible for Autologous Stem Cell Transplant
Status: COMPLETED
Conditions: Mantle Cell Lymphoma
Interventions: BIOLOGICAL: Ofatumumab (This arm is closed)|OTHER: Ofatumumab + Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Preventative Treatment With Sulfadoxine-Pyrimethamine in Gambian Multigravidae
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Sulfadoxine-pyrimethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Controlled Trial on Recreational Runners With Patellofemoral Pain
Status: COMPLETED
Conditions: Patellofemoral Pain (PFPS)
Interventions: OTHER: Education|OTHER: Exercise program|OTHER: Gait retraining
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Large-area Low-level Light Therapy for Treating Adhesive Capsulitis of the Shoulder
Status: RECRUITING
Conditions: Adhesive Capsulitis of Shoulder
Interventions: DEVICE: Low-level laser therapy (LLLT)|OTHER: Conventional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Gimatecan in Advanced Ovarian Epithelial Cancer, Fallopian Tube Cancer or Primary Peritoneal Cancer
Status: UNKNOWN
Conditions: Ovarian Epithelial Cancer|Fallopian Tube Cancer|Primary Peritoneal Cancer
Interventions: DRUG: Gimatecan 0.6mg/m2/d|DRUG: 0.8mg/m2/d|DRUG: 0.4mg/m2/d
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Study to Investigate the Inflammatory Response During a Cold Sore Episode
Status: COMPLETED
Conditions: Herpes Labialis
Interventions: DEVICE: Acyclovir patch|DEVICE: Placebo patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Probiotic GanedenBC30 for Irritable Bowel Syndrome and Major Depressive Disorder
Status: TERMINATED
Conditions: Major Depressive Disorder|Irritable Bowel Syndrome
Interventions: DRUG: Ganeden BC30|OTHER: Placebo (sugar pill)|OTHER: Ganeden BC30, Placebo (sugar pill)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Eurosarc Study of Mifamurtide in Advanced Osteosarcoma (MEMOS)
Status: TERMINATED
Conditions: Osteosarcoma
Interventions: DRUG: Mifamurtide|DRUG: Ifosfamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short-Course Isoniazid and Rifampin Compared With Isoniazid for Latent Tuberculosis Infection
Status: TERMINATED
Conditions: Tuberculosis
Interventions: DRUG: I ( isoniazid), II (isoniazid + rifampin )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First Line Treatment by FOLFIRINOX for Patients With a Rectum Cancer With Synchronous Non Resectable Metastasis
Status: COMPLETED
Conditions: Adenocarcinoma of Rectum
Interventions: DRUG: FOLFORINOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-guided Cognitive Behavioral Therapy for Insomnia in Military Service Members With History of TBI
Status: COMPLETED
Conditions: Insomnia Chronic|Mild Traumatic Brain Injury
Interventions: DEVICE: Sleep Healthy Using the Internet (SHUTi)|OTHER: Education Control Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Camrelizumab for the Treatment of Locally Advanced Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Camrelizumab|DRUG: Gemcitabine|DRUG: Induction Cisplatin|RADIATION: intensity-modulated radiotherapy|DRUG: Concurrent cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Autologous Autovaccine in Patients With Allergy on House-dust-mite
Status: COMPLETED
Conditions: Allergens, House Dust Mites
Interventions: BIOLOGICAL: Injection of autovaccine (Autovaccine Symbiopharm)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Isatuximab in Type I Cryoglobulinemia
Status: UNKNOWN
Conditions: Multiple Myeloma|Monoclonal Gammopathy of Undetermined Significance|Cryoglobulinemic Vasculitis
Interventions: DRUG: Isatuximab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of Nivolumab in Combination with Paclitaxel in Subjects with Head and Neck Cancer Unable for Cisplatin-based Chemotherapy (NIVOTAX)
Status: COMPLETED
Conditions: Recurrent Head and Neck Squamous Cell Carcinoma|Head and Neck Cancer Stage IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics of VI-0521 in Subjects With Hepatic Impairment
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: Phentermine and Topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Superficial Cervical Plexus Block on Postoperative Recovery Quality and Pain in Anterior Cervical Spinal Surgery
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: DIAGNOSTIC_TEST: superficial cervical block|DIAGNOSTIC_TEST: without superficial cervical block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Development of an In-vitro System to Identify Gynecologic Cancer Cells During Surgical Procedures
Status: UNKNOWN
Conditions: Gynecological Malignancies
Interventions: DEVICE: Mid-Infrared Spectroscopy with ATR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Multicenter Phase 2 Trial: a Tailored Strategy for Locally Advanced Rectal Carcinoma
Status: COMPLETED
Conditions: Locally Advanced Malignant Neoplasm|Rectal Carcinoma
Interventions: DRUG: Induction trichemotherapy - FOLFIRINOX regimen|OTHER: Early tumor response evaluation by MRI volumetry|RADIATION: Radiochemotherapy Cap 50|RADIATION: Radiochemotherapy Cap 60|PROCEDURE: Radical proctectomy with total mesorectal excision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DWI MR-enterography Without or With Bowel Cleansing to Assess Intestinal Inflammatory Activity in the Follow-up of Crohn's Disease
Status: RECRUITING
Conditions: Crohn Disease|Bowel Cleansing|Apparent Diffusion Coefficient
Interventions: OTHER: MR-enterography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Stroke Of Mindfulness: Investigating Physiological and Psychological Well-being
Status: COMPLETED
Conditions: Stroke|Stress|Anxiety|Depression
Interventions: BEHAVIORAL: Mindfulness-Based Intervention|BEHAVIORAL: Waitlist - Mindfulness-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraarticular Corticosteroid Therapy in Perthes Disease.
Status: TERMINATED
Conditions: Legg-Calve Perthes Disease
Interventions: DRUG: Aristospan 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Patellar Eversion on Functional Outcomes in Primary Total Knee Arthroplasty
Status: COMPLETED
Conditions: Total Knee Replacement|Arthroplasty|Patella
Interventions: PROCEDURE: Primary Total Knee Replacement Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Blended Low Intensity Internet-delivered Psychological Program in Patients With Multimorbidity in Primary Care.
Status: COMPLETED
Conditions: Depression|Chronic Disease (Diabetes/Low Back Pain)
Interventions: BEHAVIORAL: Low intensity Internet-delivered psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Non-mydriatic Camera Systems in a Female Health Hospital
Status: COMPLETED
Conditions: Eye Diseases|Retina; Lesion|Optic Disc Structural Anomaly
Interventions: OTHER: Retinal imaging|OTHER: Vessel measurements|OTHER: Change in vessel diameters
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of a Orally Inhaled Fluticasone Furoate on Growth Velocity in Prepubertal, Paediatric Subjects With Asthma Over a Year
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone furoate|DRUG: Placebo|DRUG: Montelukast|DRUG: Short Acting Beta 2 Agonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunohistochemical Study of Neurodegenerative Diseases
Status: RECRUITING
Conditions: Alzheimer Disease|Lewy Body Disease|Neurodegenerative Diseases
Interventions: BIOLOGICAL: Detection of cytof in peripheral PBMC|DRUG: Donepezil for patients with AD and DLB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treating H. Pylori in Parkinson's Patients With Motor Fluctuations
Status: TERMINATED
Conditions: Parkinson's Disease|Helicobacter Infections|Motor Fluctuations
Interventions: DRUG: clartihromycin, amoxicillin, and omeprazole|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple-dose Study to Evaluate the Efficacy, Safety and Pharmacokinetics of BMS-646256 in Obese Subjects
Status: TERMINATED
Conditions: Obesity
Interventions: DRUG: BMS-646256|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Norwegian Prednisolone in Early Psychosis Study
Status: TERMINATED
Conditions: Schizophrenia and Related Disorders|Immune Suppression|Psychosis|Cognitive Change
Interventions: DRUG: Prednisolone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of an Updated Bone-anchored Sound Processor
Status: COMPLETED
Conditions: Hearing Loss|Hearing Loss, Conductive|Hearing Loss, Mixed|Hearing Disorders|Deafness|Ear Diseases|Otorhinolaryngologic Diseases|Sensation Disorders|Neurologic Manifestations|Nervous System Diseases
Interventions: DEVICE: Device A|DEVICE: Device B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Low Back Pain Presented to the Emergency Department
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: DRUG: Paracetamol|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing Chronic Depression and PTSD in Stroke Patients Admitted to the Neuroscience Intensive Care Unit (NICU) and Their Family Caregivers
Status: COMPLETED
Conditions: Neurological Disorder
Interventions: BEHAVIORAL: Psychosocial Skills-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Bimagrumab/BYM338 at 52 Weeks on Physical Function, Muscle Strength, Mobility in sIBM Patients
Status: COMPLETED
Conditions: Sporadic Inclusion Body Myositis
Interventions: DRUG: BYM338/bimagrumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Sevikar® and the Combination of Perindopril/Amlodipine on Central Blood Pressure
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Perindopril + amlodipine + if necessary, hydrochlorothiazide|DRUG: olmesartan/amlodipine + hydrochlorothiazide, if necessary.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation Intentions for Weight Loss and Dietary Change in College Students With Overweight and Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Implementation Intentions|BEHAVIORAL: Fluency Training|BEHAVIORAL: Text Messages|BEHAVIORAL: Goal Intentions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DAILY: Vitamin D, Aspirin, ExercIse, Low Saturated Fat Foods StudY in Colorectal Cancer Patients With Minimal Residual Disease
Status: RECRUITING
Conditions: Colorectal Cancer|Colon Cancer
Interventions: DRUG: Aspirin|DRUG: Vitamin D|DIETARY_SUPPLEMENT: Diet|OTHER: Physical Activity|BEHAVIORAL: Behavioral Support Counseling Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pregnenolone for the Treatment of Alcohol Use Disorder
Status: RECRUITING
Conditions: Alcohol Use Disorder
Interventions: DRUG: Pregnenolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LA Improves the Prognosis of Patients With ICVD After Surgery
Status: NOT_YET_RECRUITING
Conditions: Ischemia; Cerebrovascular|Cognitive Impairment
Interventions: DIETARY_SUPPLEMENT: Lactobacillus acidophilus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integration of Tai Chi and Repetitive Transcranial Magnetic Stimulation for Sleep Disturbance in Older Adults
Status: COMPLETED
Conditions: Sleep Disturbance|Interaction
Interventions: OTHER: TC plus active rTMS|OTHER: Tai Chi plus sham rTMS|BEHAVIORAL: TC-alone|BEHAVIORAL: Low intensity physical exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of the Combination of SHR-A1811 and Fluzoparib in HER2-Expressing Cancers
Status: ENROLLING_BY_INVITATION
Conditions: Advanced Solid Tumors
Interventions: DRUG: SHR-A1811|DRUG: Fluzoparib Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Memory, Thinking, and Brain Imaging in Adults With Histiocytosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Histiocytosis
Interventions: BEHAVIORAL: Trail Making Test, Parts A & B|BEHAVIORAL: Brief Test of Attention|BEHAVIORAL: Symbol Span|BEHAVIORAL: Controlled Oral Word Association Test|BEHAVIORAL: The Hopkins Verbal Learning Test-Revised|BEHAVIORAL: Brief Visuospatial Memory Test-Revised|BEHAVIORAL: Hospital Anxiety and Depression Scale|BEHAVIORAL: McGill Quality of Life Scale|DIAGNOSTIC_TEST: MR Brain Imaging|DIAGNOSTIC_TEST: Resting state functional MRI|BEHAVIORAL: Functional Assessment of Cancer Therapy Cognitive Scale (FACT-Cog)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study on the Effects of Wheat and Corn Germ Blend Oil on Antioxidation and Immune Regulation of Dyslipidemia Population
Status: ACTIVE_NOT_RECRUITING
Conditions: Metabolic Diseases|Immune System Disorder|Dyslipidemias|Fatty Acid Metabolism Disorder|Oxidative Stress
Interventions: DIETARY_SUPPLEMENT: Phytosterol-rich Wheat and Corn Germ Blended Oil|DIETARY_SUPPLEMENT: Peanut oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of a Web-Based Emotion Regulation Intervention for Patients With Congenital Heart Disease
Status: RECRUITING
Conditions: Congenital Heart Disease|Emotional Regulation
Interventions: OTHER: CHD-specific web-based emotion regulation intervention|OTHER: General web-based emotion regulation intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Clinical Efficacy of a Dentifrice Containing 5% Fluoro Calcium Phosphosilicate to a Dentifrice Containing Calcium Sodium Phosphosilicate on Dentinal Hypersensitivity
Status: COMPLETED
Conditions: Dentinal Hypersensitivity
Interventions: OTHER: 5% fluorocalcium phosphosilicate dentifrice|OTHER: Calcium sodium phosphosilicate|OTHER: Placebo dentrifice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the CRE8 Sirolimus-Eluting Stent for the Treatment of De Novo Coronary Artery Lesions
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: CRE8 sirolimus-eluting stent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Defining the PrEP Care Continuum Among Recently Incarcerated Men at High-Risk for HIV Infection
Status: UNKNOWN
Conditions: HIV Infections|Sexually Transmitted Diseases
Interventions: DRUG: Emtricitabine / Tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase I Trial of VS-6766 Alone and in Combination With Everolimus
Status: RECRUITING
Conditions: Solid Tumours|Multiple Myeloma|Lung Cancer|Ovarian Cancer
Interventions: DRUG: VS-6766|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimal Invasive Imaging of Coronary Artery Disease in Patients With Asymptomatic Myocardial Injury After Major Non-cardiac Surgery.
Status: UNKNOWN
Conditions: Myocardium; Injury|Coronary Artery Disease
Interventions: OTHER: Minimal invasive cardiac imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Six-Minute Walk Test Comparing Helium/Oxygen to Nitrogen/Oxygen for COPD Rehabilitation
Status: TERMINATED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Inhalation gas|DRUG: Inhalation Nitrogen/Oxygen|DRUG: Inhalation Helium/Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The IPLA-OVCA Trial, Intra-Peritoneal Local Anaesthetics in Ovarian Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Ovarian Cancer
Interventions: DRUG: Ropivacaine|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Bioequivalence Study of Linagliptin 5 mg Film-coated Tablet in Healthy Thai Volunteers
Status: NOT_YET_RECRUITING
Conditions: Healthy Volunteer
Interventions: DRUG: Linagliptin 5 mg Oral Tablet|DRUG: Trajenta 5 MG Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Reducing Suicidal Ideation Through Insomnia Treatment
Status: COMPLETED
Conditions: Insomnia|Depression|Suicidal Ideation
Interventions: DRUG: Zolpidem-CR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of BLI5100 in Patients With Erosive Esophagitis
Status: RECRUITING
Conditions: Erosive Esophagitis
Interventions: DRUG: BLI5100|DRUG: PPI Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Trial of Sodium Valproate, in Paediatric and Adult Patients With Wolfram Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Wolfram Syndrome
Interventions: DRUG: Sodium Valproate 200Mg E/C Tablet|DRUG: Sodium Valproate matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study on Mastocytosis for Rupatadine Treatment
Status: COMPLETED
Conditions: Mastocytosis
Interventions: DRUG: Rupatadin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Para-sternal Block on Postoperative Respiratory Function After Cardiac Sternotomy Surgery
Status: UNKNOWN
Conditions: Cardiac Surgery|Ultrasound-guided Parasternal Block|Postoperative Pulmonary Complications|Pulmonary Function Testing
Interventions: DRUG: parasternal block|DRUG: Standard pain management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of BKM120 and Everolimus in Advanced Solid Malignancies
Status: COMPLETED
Conditions: Solid Tumors|Lung Cancer
Interventions: DRUG: BKM120|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stanford Clinics Physician Mindset Training
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus|Hypertension|Pre Diabetes|Overweight and Obesity
Interventions: BEHAVIORAL: Mindset & Communication Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Low-calorie Diet on Serum Lipids, Adipokines, Insulin Resistance and Also Body Composition in Women With Metabolic Syndrome
Status: COMPLETED
Conditions: Weight Loss|Insulin Resistance|Adipokines
Interventions: OTHER: Low-calorie diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Pregabalin, Alprazolam, and Placebo in Subjects With Anxiety Prior to Dental Procedure
Status: COMPLETED
Conditions: Dental Anxiety
Interventions: DRUG: Pregabalin|DRUG: Alprazolam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Orientation Characteristics of Kalifilcon A Daily Disposable Toric Contact Lenses Compared to Acuvue Oasys 1-Day for Astigmatism Contact Lenses
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: Kalifilcon a Contact Lens for Astigmatism|DEVICE: Acuvue Oasys 1-Day for Astigmatism
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Immunoradiotherapy in Head & Neck Cancer (NIRT 2-HNC)
Status: RECRUITING
Conditions: Head and Neck Cancer|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Pembrolizumab|RADIATION: Stereotactic Body Radiation Therapy (5 days)|PROCEDURE: Surgical Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the IDH1 Inhibitor AG-120 in Combination With the Checkpoint Blockade Inhibitor, Nivolumab, for Patients With IDH1 Mutated Relapsed/Refractory AML and High Risk MDS
Status: WITHDRAWN
Conditions: Myelodysplastic Syndromes|Acute Myeloid Leukemia
Interventions: DRUG: AG-120|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Guanfacine Clinical Trial for Smoking Cessation
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Guanfacine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a New Medication for Childhood Chronic Immune Thrombocytopenia (ITP), a Blood Disorder of Low Platelet Counts That Can Lead to Bruising Easily, Bleeding Gums, and/or Bleeding Inside the Body.
Status: COMPLETED
Conditions: Idiopathic Thrombocytopenic Purpura
Interventions: DRUG: Eltrombopag|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sedation During Pediatric Diagnostic Gastrointestinal Endoscopy Gastrointestinal Endoscopy
Status: UNKNOWN
Conditions: Sedation
Interventions: DRUG: Fentanyl|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Trial of Stereotactic Body Radiotherapy With Concurrent Fixed Dose Tyrosine Kinase Inhibitors in Metastatic Renal Cell Carcinoma: Dose Limiting Toxicity and Abscopal Effect.
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: RADIATION: Stereotactic body radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 48-Week, Open Label, Study to Evaluate the Efficacy and Safety of AMONDYS 45, EXONDYS 51, VYONDYS 53 in Subjects With DuchenneMuscular Dystrophy Carrying Eligible DMD Duplications.
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: Amondys 45|DRUG: Exondys 51|DRUG: Vyondys 53
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Fish Oil on Patients With Chronic Nonspecific Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: DIETARY_SUPPLEMENT: Fish oil|DIETARY_SUPPLEMENT: Placebo|PROCEDURE: Hotpacking|PROCEDURE: Transcutaneous electrical nerve stimulation (TENS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electroconvulsive Treatment Followed by Cognitive Control Training
Status: TERMINATED
Conditions: Depressive Episode|Electroconvulsive Therapy|Cognitive Remediation
Interventions: BEHAVIORAL: Cognitive Control Training|BEHAVIORAL: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quantification and Characterization of Circulating Epithelial and Endothelial Cells in Gougerot-Sjögren Syndrome, Compared to Systemic Sclerosis
Status: RECRUITING
Conditions: Primary Gougerot-Sjögren Syndrome|Systemic Sclerosis, Diffuse
Interventions: OTHER: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Trial Studying the Effects of Spironolactone on Heart and Skeletal Muscle Function in Chronic Alcoholics
Status: SUSPENDED
Conditions: Cardiomyopathy, Alcoholic|Alcoholism
Interventions: DRUG: spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I Trial
Status: RECRUITING
Conditions: Cigarette Smoking-Related Carcinoma
Interventions: DRUG: Bupropion Hydrochloride Controlled-release|DRUG: Nicotine Replacement|OTHER: Questionnaire Administration|OTHER: Tobacco Cessation Counseling|DRUG: Varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Metabolic Imaging of the Heart Using Hyperpolarized (13C) Pyruvate Injection
Status: RECRUITING
Conditions: Hypertension|Hypertrophy
Interventions: DRUG: Hyperpolarized (13) Pyruvate Injection|DRUG: Gadolinium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Venovenous CO2 Removal (VVCO2R) in Patients With COPD and Acute Respiratory Failure
Status: TERMINATED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DEVICE: Venovenous CO2 Removal (VVCO2R) in COPD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3D Printed Donor Tooth Replica in Autotransplantation of Teeth
Status: UNKNOWN
Conditions: Decayed Teeth
Interventions: PROCEDURE: 3D printed replica of the donor tooth|PROCEDURE: Conventional Autotransplantation of tooth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate DCR-PHXC in Children and Adults With Primary Hyperoxaluria Type 1 and Primary Hyperoxaluria Type 2
Status: COMPLETED
Conditions: Primary Hyperoxaluria Type 1 (PH1)|Primary Hyperoxaluria Type 2 (PH2)|Kidney Diseases|Urologic Diseases|Genetic Disease
Interventions: DRUG: DCR-PHXC|DRUG: Sterile Normal Saline (0.9% NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Amnion Chorion Membrane and Demineralized Bone Matrix Putty Allograft in Periodontal Intrabony Defects
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: BIOLOGICAL: Demineralized bone matrix in putty form|BIOLOGICAL: Amnion chorion membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Multimodal Physical Activity Intervention in Patients With Chronic Nonspecific Low Back Pain
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: OTHER: Physical Activity Intervention|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study : New Sensors to Monitor Apnea During Sedation
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive|Anesthesia
Interventions: DEVICE: JAWAC system + Capnoline + Spo2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Testing the Effectiveness of Cognitive Training Among Depressed Patients Receiving Esketamine Treatment
Status: SUSPENDED
Conditions: Depression
Interventions: BEHAVIORAL: Cognitive Training|BEHAVIORAL: Sham Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Olopatadine and Fluticasone in Patients With Allergic Conjunctivitis
Status: COMPLETED
Conditions: Conjunctivitis, Allergic
Interventions: DRUG: Olopatadine|DRUG: Fluticasone|DRUG: Saline|DRUG: Artificial tears
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Effect of Omega-3 vs Soy Isoflavones in Postmenopausal Women With Moderate to Severe Vasomotor Symptoms
Status: COMPLETED
Conditions: Menopause|Hot Flashes
Interventions: DIETARY_SUPPLEMENT: Omega-3|DIETARY_SUPPLEMENT: Soy Isoflavones
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE