pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Assess the Safety of ELGN-2112 in Preterm Infants Born Under 26 Weeks GA and IUGR Infants Born 26-32 Weeks GA
Status: NOT_YET_RECRUITING
Conditions: Intestinal Malabsorption
Interventions: DRUG: ELGN-2112|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Mitral Regurgitation in Hypertrophic Obstructive Cardiomyopathy: Fix it in a Simple, Effective and Durable Way!
Status: COMPLETED
Conditions: Hypertrophic Obstructive Cardiomyopathy|Mitral Regurgitation
Interventions: PROCEDURE: Septal myectomy and mitral valve repair with edge-to-edge technique
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Overnight and In-house 3D-printed Patient-specific Casts for Non-operative Treatment of Distal Radius Fractures
Status: COMPLETED
Conditions: Radius Fracture Distal
Interventions: DEVICE: 3D-printed cast|DEVICE: Conventional cast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rôle of the Soluble Endothelial Protein C Receptor in Cirrhosis-associated Hypercoagulability State (EXERCISE)
Status: UNKNOWN
Conditions: Cirrhosis
Interventions: BIOLOGICAL: Thrombin generation assay (in vitro)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Examination of Plasma Concentrations and Safety in Chronic Kidney Disease Patients Undergoing Hemodialysis
Status: COMPLETED
Conditions: Patients on Stable Chronic Maintenance Dialysis Who Are Receiving Hemodialysis Therapy|Pharmacodynamics of ASP7991|Pharmacokinetics of ASP7991
Interventions: DRUG: ASP7991
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical and Radiographic Evaluation of Crestal Bone Loss Around Implant With or Without Platform Switching Design
Status: COMPLETED
Conditions: Crestal Bone Loss
Interventions: PROCEDURE: Platform Matched Design (Group A)|PROCEDURE: Platform Switching Design (Group B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Prostatectomy for Castration-Naive Oligometastatic Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostatectomy|Oligometastatic Prostate Cancer|Abiraterone
Interventions: PROCEDURE: robot assisted laparoscopic prostatectomy + enlarged pelvic lymph node dissection|DRUG: 1.Abiraterone Acetate Tablets|DRUG: Prednisone Acetate Tablets|DRUG: Luteinizing Hormone-Releasing Hormone Analog
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY110140 in Healthy Japanese Male Participants
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: LY110140|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Of The Neck And Scapular Proprioceptive Neuromuscular Facilitation Exercises On Postural Disorders, Scapular Dyskinesia And Round Shoulders in Individuals With Cervical Sagittal Alignment Disorder.
Status: COMPLETED
Conditions: Forward Head Posture|Sagittal Cervical Malalignment|Rounded Shouler|Scapular Dyskinesis
Interventions: OTHER: Scapular and Neck Proprioceptive Neuromuscular Facilitation exercises|OTHER: McKenzie and Kendall exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cultural Tailoring and Pilot Testing of an Inpatient Yoga Therapy Program for Cancer Patients Undergoing Hematopoietic Stem Cell Transplantation in India, Tanzania, and the United States
Status: RECRUITING
Conditions: Hematopoietic Stem Cell Transplantation|Cancer
Interventions: BEHAVIORAL: Yoga Sessions|BEHAVIORAL: Questionnaries|BEHAVIORAL: Interviews
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Identification of a Biomarker Predictive of Evolution of Parkinson Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: [18F]DPA-714 PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Intravenous Granisetron and Ondansetron in Patients Undergoing Cesarean Section
Status: COMPLETED
Conditions: Vomiting, Postoperative|Postoperative Complications|Hypotension
Interventions: DRUG: ondansetron|DRUG: Granisetron|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Phase 1 Study of a H5N1 Influenza Vaccine (Reverse Genetic Reassortant)
Status: COMPLETED
Conditions: Influenza|Pandemic Influenza
Interventions: BIOLOGICAL: H5N1 Influenza Vaccine, Whole virion, Vero cell-derived, Inactivated Influenza Vaccine, non-adjuvanted (reverse genetic reassortant/H5N1 hemagglutinin antigen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate Safety and Pharmacokinetics of UB-421 Antibody in HIV-1 Infected Adults
Status: COMPLETED
Conditions: HIV-1 Infection in Adults (Asymptomatic)
Interventions: DRUG: Antibody UB-421
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Avastin in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Avastin (Bevacizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Adhesion Quality and Wear of Placebo JNJ-35685-AAA-G-023 Transdermal System in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-35684-AAA-023: Size 1; small patch|DRUG: JNJ-35684-AAA-023: Size 2; large patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Donor Selection on the Outcome of Faecal Microbiota Transplantation in Patients With Irritable Bowel Syndrome
Status: NOT_YET_RECRUITING
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Faeces
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Beta-blocker on Cardioprotective Effect of Remote Ischemic Conditioning
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: Beta Blockers Carvedilol Phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Myopia Intervention in Children and Adolescents and Establishment of a Precise Intervention Model
Status: UNKNOWN
Conditions: Myopia
Interventions: DRUG: Atropine Sulfate 0.01% Eye Drop|DEVICE: Orthokeratology|DRUG: Atropine Sulfate 0.04% Eye Drop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hypnotic Intervention for Women With Chronic Pelvic Pain
Status: COMPLETED
Conditions: Chronic Pain|Pelvic Pain|Psychological|Hypnosis, Animal
Interventions: OTHER: Hypnotic intervention for persistent pelvic pain.|OTHER: Control group persistent pelvic pain no intervention.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Mother DHA Supplementation on Term Newborn.
Status: COMPLETED
Conditions: Oxidative Stress|Inflammation|Infant Development
Interventions: DIETARY_SUPPLEMENT: DHA Supplementation|DIETARY_SUPPLEMENT: Control (milk without DHA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Coronariography in OUt of hosPital Cardiac arrEst
Status: COMPLETED
Conditions: Cardiac Arrest
Interventions: PROCEDURE: Urgent Coronary Angiography|PROCEDURE: Deferred Coronary Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing the Social Engagement System in Prader-Willi Syndrome: Insights From the Polyvagal Theory
Status: TERMINATED
Conditions: Prader-Willi Syndrome
Interventions: BEHAVIORAL: Listening Project Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Psychosis-Associated Neuroinflammation in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Psychosis
Interventions: RADIATION: [18F]-PBR111 Positron Emission Tomography (PET)|BEHAVIORAL: Cognitive and psychomotor tasks|BIOLOGICAL: Blood sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Functional Respiratory Imaging Study (FRI)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Beclometasone dipropionate/Formoterol Fumarate/Glycopyrronium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of VB119 in Subjects With Minimal Change Disease (MCD) and Focal Segmental Glomerulosclerosis (FSGS)
Status: TERMINATED
Conditions: Minimal Change Disease|Focal Segmental Glomerulosclerosis
Interventions: DRUG: VB119
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of IV HBI-3000 for the Conversion Recent Onset Atrial Fibrillation (AF)
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: HBI-3000|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Oral Contraceptives on DNIC in Non-painful Healthy Women
Status: COMPLETED
Conditions: Contraceptive Usage|Diffuse Noxious Inhibitory Control
Interventions: DEVICE: Mechanical stimulus|PROCEDURE: Thermal (cold) stimulus|OTHER: Oral contraceptive (OC)|OTHER: No oral contraceptive (No OC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: MEDICLAS Study (Metabolic Effects of Different Classes of AntiretroviralS)
Status: UNKNOWN
Conditions: HIV Infections|HIV-Associated Lipodystrophy Syndrome
Interventions: DRUG: Lopinavir/ritonavir + zidovudine + lamivudine|DRUG: Lopinavir/ritonavir + nevirapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: Decitabine With or Without Bortezomib in Treating Older Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Therapy-Related Acute Myeloid Leukemia
Interventions: DRUG: Bortezomib|DRUG: Decitabine|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Extension Study for Patients With Duchenne Muscular Dystrophy Who Participated in Studies of SRP-5051 (Vesleteplirsen)
Status: TERMINATED
Conditions: Muscular Dystrophy, Duchenne
Interventions: DRUG: SRP-5051
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Controlled, Multicenter Trial of Filgrastim (Recombinant-Methionyl Human Granulocyte Colony Stimulating Factor; G-CSF) for the Prevention of Grade 4 Neutropenia in Patients With HIV Infection.
Status: COMPLETED
Conditions: HIV Infections|Cytopenias
Interventions: DRUG: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Drug Interaction Study of Clarithromycin and LY3502970 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3502970|DRUG: Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Connective Tissue Graft Versus Mucograft Collagen Matrix for Coverage of Multiple Gingival Recession Defects
Status: COMPLETED
Conditions: Gingival Recession
Interventions: PROCEDURE: Autologous connective tissue graft with rotated papilla flap|DEVICE: Collagen matrix construct (Mucograft)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-center Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution in Subjects With Primary Open-angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-angle Glaucoma or Ocular Hypertension
Interventions: DRUG: DE-117 ophthalmic solution|DRUG: latanoprost ophthalmic solution|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Response Profile of A-101 in Subjects With Seborrheic Keratosis
Status: COMPLETED
Conditions: Seborrheic Keratosis
Interventions: DRUG: A-101 Vehicle|DRUG: A-101 (40) Topical Solution|DRUG: A-101 (32.5) Topical Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Topiramate to Reduce Cocaine Dependence
Status: COMPLETED
Conditions: Cocaine-Related Disorders
Interventions: DRUG: Topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Collaborative Lifestyle Intervention Program in Knee Osteoarthritis Patients
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: BEHAVIORAL: Exercise and Dietary Weight Loss|BEHAVIORAL: Walk with Ease
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treating Post Traumatic Stress Disorder in Children Exposed to Domestic Violence
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic|Anxiety|Depression
Interventions: BEHAVIORAL: Trauma-focused cognitive behavioral therapy (TF-CBT)|BEHAVIORAL: Child-centered supportive therapy (CCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture to Reduce Chemotherapy-induced Peripheral Neuropathy Severity During Neoadjuvant or Adjuvant Weekly Paclitaxel Chemotherapy in Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer|Peripheral Neuropathy
Interventions: PROCEDURE: Acupuncture|BEHAVIORAL: Neuropathic Pain Scale (NPS) questionnaire|BEHAVIORAL: FACT/GOG-Ntx questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Secretin-enhanced Magnetic Resonance Imaging (S-MRI) for Pancreatic Cancer Detection
Status: WITHDRAWN
Conditions: Pancreatic Cancer|Intraductal Papillary Mucinous Neoplasm
Interventions: DRUG: Secretin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Evaluate the Efficacy to Acute and Chronic Bronchitis
Status: COMPLETED
Conditions: Acute Exacerbation of Chronic Bronchitis
Interventions: DRUG: Combination of Broussonetia spp and Lonicera spp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Predicting Bispectral Index Values by Estimated Effect-site Concentration of Propofol and Remifentanil Displayed on the Target-centered Infusion Pump
Status: UNKNOWN
Conditions: General Anesthesia|Total Intravenous Anesthesia|Bispectral Index Monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of Levemir® Improves Metabolic and Clinical Status in Cystic Fibrosis-related Diabetes (CFRD)
Status: TERMINATED
Conditions: Cystic Fibrosis Related Diabetes
Interventions: DRUG: insulin detemir [rDNA origin] injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of STSP-0601 in Adult Patients With Hemophilia A or B Without Inhibitor
Status: COMPLETED
Conditions: Hemophilia
Interventions: DRUG: STSP-0601 for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Neprilysin on Glucagon-Like Peptide-1 in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type2 Diabetes
Interventions: DRUG: Entresto|DRUG: Sitagliptin|DRUG: Valsartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Stool Transplant for Patients With Difficult to Treat C. Difficile Infection
Status: COMPLETED
Conditions: C. Difficile Infection|Cancer
Interventions: BIOLOGICAL: Fecal Microbiota Transplantation (FMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TRACER RGD-K5 Carotid Plaque Imaging Study
Status: TERMINATED
Conditions: Carotid Artery Disease|Carotid Stenosis
Interventions: DRUG: [F-18] RDG-K5
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Transurethral Plasmakinetic Enucleation of Prostate Versus Transurethral Resection of Prostate
Status: UNKNOWN
Conditions: Benign Prostatic Hyperplasia
Interventions: PROCEDURE: Transurethral plasmakinetic enucleation of prostate|PROCEDURE: transurethral resection of prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Pharmacokinetics of GS-4059 (Tirabrutinib) in Healthy Volunteers and Participants With Rheumatoid Arthritis (RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tirabrutinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics and Safety of DBPR108 in Subjects With Hepatic Impairment
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: DBPR108 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Olivomed (Olive Extract) on Endothelial, Cardiac and Vascular Function
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DIETARY_SUPPLEMENT: Olivomed (capsules containing hydroxytyrosol)|DIETARY_SUPPLEMENT: OlivomedSmart - Capsules containing - combination of Oleuropein (OL), Hydroxytyrosol (HT), Oleocanthal (OC) - (OL:HT:OC 2:1:3), (5 mg HT bid).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Paediatric Hepatic International Tumour Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatoblastoma|Carcinoma, Hepatocellular
Interventions: DRUG: Cisplatin|DRUG: Doxorubicin|DRUG: Carboplatin|DRUG: 5Fluorouracil|DRUG: Vincristine|DRUG: Etoposide|DRUG: Irinotecan|DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Low Level Light Irradiation on Insomniacs' Meridians During the First Sleep Cycle.
Status: UNKNOWN
Conditions: Insomnia
Interventions: DEVICE: laser acupuncture|DEVICE: sham device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lactobacillus Acidophilus and Postmenopausal Osteoporosis Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Bone Loss|Post Menopausal Osteoporosis|Mineralization
Interventions: DIETARY_SUPPLEMENT: Probiotic group|DIETARY_SUPPLEMENT: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sequential Versus Quadruple Therapy in the Second-line Treatment
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Esomeprazole (S14)|DRUG: Esomeprazole (BQ10)|DRUG: Amoxicillin (ST14)|DRUG: Clarithromycin (ST14)|DRUG: Metronidazole (ST14)|DRUG: dibismuth trioxide 120mg (BQ10)|DRUG: Metronidazole (BQ10)|DRUG: tetracycline (BQ10)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Of Cisplatin And KML-001 in Platinum Responsive Malignancies
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer, Small Cell Lung Cancer|Platinum Responsive Malignancies
Interventions: DRUG: KML-001|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alcoholism and Schizophrenia: Effects of Clozapine
Status: TERMINATED
Conditions: Schizophrenia|Dual Diagnosis|Schizoaffective Disorder|Psychotic Disorder|Substance Abuse|Alcohol Abuse
Interventions: DRUG: Clozapine versus typical (conventional) and atypical antipsychotic medications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: OTHER
Clinical trial: Initial Treatment With Bevacizumab in Choroidal Neovascularization Associated to High Myopia
Status: COMPLETED
Conditions: Choroidal Subfoveal/Juxtafoveal Neovascularization in High Myopia
Interventions: DRUG: Bevazizumab intravitreal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Synbiotics and Low Grade Inflammation in Obese Subjects
Status: UNKNOWN
Conditions: Obesity|Diabetes Mellitus Type-2|Insulin Resistance|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Synbiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Between Deep Dry Needling and Muscle Energy Technique on Chronic Non-specific Neck Pain Patients.
Status: COMPLETED
Conditions: Neck Pain
Interventions: PROCEDURE: Deep dry needling|PROCEDURE: Muscle energy technique|PROCEDURE: Neck stability exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Left Bundle Branch Pacing in Patients With Cardiac Dysfunction and AV Block
Status: NOT_YET_RECRUITING
Conditions: Atrioventricular Block, Second and Third Degree|Heart Failure|Left Bundle Branch Pacing
Interventions: DEVICE: Left bundle branch pacing|DEVICE: Bi-ventricular pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Micronized and Ultramicronized Palmitoylethanolamide in Fibromyalgia Patients
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DIETARY_SUPPLEMENT: micronized and ultra-micronized Palmitoylethanolamide (mPEA and umPEA, 300mg + 600mg) microgranules|OTHER: Placebo microgranules 1800mg|DRUG: Standard Therapy|DRUG: Rescue Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Improving Outcomes in Depression in Primary Care in a Low Resource Setting
Status: RECRUITING
Conditions: Depression|Depressive Disorder
Interventions: BEHAVIORAL: Healthy Activity Program (HAP)|DRUG: Antidepressant medication (fluoxetine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study Validating the Use of Candin as a Challenge Agent in Healthy Participants - Intervention Specific Appendix 1
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cosentyx|DRUG: Candin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Metacognition-based, Manualized Intervention on Fear of Cancer Recurrence
Status: COMPLETED
Conditions: Fear of Cancer Recurrence
Interventions: OTHER: ConquerFear Intervention|OTHER: Active control: Basic Cancer Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Peptones Load in Normocalcemic and Hypercalcemic Primary Hyperparathyroidism and Healthy Subjects
Status: COMPLETED
Conditions: Hyperparathyroidism|Hypercalcemia
Interventions: OTHER: Oral peptones load
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of OXY111A in Primary and Secondary Hepato-Pancreato-Biliary Neoplasm
Status: UNKNOWN
Conditions: Pancreatic Neoplasms|Hepatocellular Cancer|Cholangiocarcinoma|Colorectal Neoplasms
Interventions: DRUG: OXY111A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trilogy AB Acetabular Hip System Post Approval Study
Status: TERMINATED
Conditions: Osteoarthritis|Avascular Necrosis|Congenital Hip Dysplasia|Traumatic Arthritis
Interventions: DEVICE: Trilogy AB Acetabular Hip Implant System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multidimensional Impact of Telemonitoring in Heart Failure (IMPACT-HF)
Status: RECRUITING
Conditions: Heart Failure
Interventions: OTHER: Telemonitoring follow-up using medical devices and telematic consultations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of the Cycle Ergometer in Muscle Strength and Pulmonary Function in Patients in Hemodialysis
Status: COMPLETED
Conditions: Chronic Renal Disease|Renal Dialysis
Interventions: OTHER: Cicloergometry training|OTHER: No Cicloergometry training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Anti-Interleukin-8 (Anti-IL-8) for Patients With COVID-19
Status: TERMINATED
Conditions: Solid Tumor|Sars-CoV2|Hematological Malignancy
Interventions: DRUG: BMS-986253
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incorporating Endoscopic Ultrasound and Elastography Towards Improving Outcomes of Pediatric Pancreatitis Management
Status: RECRUITING
Conditions: Chronic Pancreatitis|Acute Recurrent Pancreatitis
Interventions: DIAGNOSTIC_TEST: Transabdominal ultrasound Shear wave elastography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Magneto eTrieve™ PE Kit for Endovascular Thrombectomy in Subjects With Acute Pulmonary Embolism
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Embolism
Interventions: DEVICE: eTrieve PE Kit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of RT3D-TEE-guided Mitral Valve Repair on Outcomes in Patients With Degenerative Mitral Valve Disease
Status: RECRUITING
Conditions: Degenerative Mitral Valve Disease
Interventions: PROCEDURE: RT3D-TEE-guided mitral valve repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dulaglutide on Liver Fat in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Non Alcoholic Fatty Liver Disease|Type2 Diabetes Mellitus
Interventions: DRUG: Dulaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chronic Nausea and Vomiting in Patients With Normal Gastric Emptying Using the Enterra® Therapy System (NAVIGATE)
Status: NOT_YET_RECRUITING
Conditions: Nausea|Vomiting
Interventions: DEVICE: Enterra Therapy System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety and Efficacy of LentiGlobin BB305 Drug Product in β-Thalassemia Major (Also Referred to as Transfusion-dependent β-Thalassemia [TDT]) and Sickle Cell Disease
Status: COMPLETED
Conditions: Beta-Thalassemia Major|Sickle Cell Disease
Interventions: DRUG: LentiGlobin BB305 Drug Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Histopathological, Biochemical And Electrophysiological Evaluation Of Single Or Combined Use Of Diode Laser/Steroid Treatment On Facial Nerve Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Nerve Injury|Laser Therapy|Methylprednisolone|Facial Nerve Injuries
Interventions: DRUG: Methyprednisolon and low level laser theraphy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Genexol-PM in Patients With Advanced Urothelial Cancer Previously Treated With Gemcitabine and Platinum
Status: COMPLETED
Conditions: Bladder Cancer|Ureter Cancer
Interventions: DRUG: Genexol PM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiscale Omics for the Development of a Cohort Database and Study Platform in Breast Cancer Survivors
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage 0 Breast Cancer AJCC v8|Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Prognostic Stage 0 Breast Cancer AJCC v8|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Contrast-enhanced Diffusion-weighted MRI to Detect Liver Metastases in Patients With Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Neoplasms
Interventions: DIAGNOSTIC_TEST: Contrast-enhanced Diffusion-weighted MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy Comparator Trial of a New Drug Against Genital Herpes
Status: TERMINATED
Conditions: Genital Herpes
Interventions: DRUG: AIC316|DRUG: Valacyclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Satiating Diet, Appetite Control and Body Weight Loss in Individuals With Obesity
Status: RECRUITING
Conditions: Weight Loss|Weight Maintenance|Appetite Control
Interventions: OTHER: Non-restrictive satiating intervention|OTHER: Conventional restrictive intervention + non-restrictive satiating intervention|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Time-Restricted Feeding Intervention in Metabolically-Unhealthy Postmenopausal Women
Status: RECRUITING
Conditions: Metabolic Syndrome|Postmenopausal Symptoms
Interventions: BEHAVIORAL: Time-Restricted Feeding (TRF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: First-line Intraperitoneal Cisplatin and Etoposide Chemotherapy for Ovarian Cancer
Status: COMPLETED
Conditions: Bulky Stage IIIC and IV Epithelial Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Carcinoma
Interventions: DRUG: PEip (weekly) and TCiv|DRUG: TCiv
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Doppler in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DEVICE: TCD baseline|DEVICE: TCD after bosentan administration|DEVICE: NIRS baseline|DEVICE: NIRS after bosentan administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A Study of JAB-21822 in Advanced or Metastatic NSCLC With KRAS p.G12C and STK11 Co-mutation and Wild-type KEAP1
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: JAB 21822
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Histocompatibility Leukocyte Antigen (HLA)-A*0201 Restricted Peptide Vaccine Therapy in Patients With Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: VEGFR1 and VEGFR2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Amino Acids on Hepatic Fat Content in Adolescents (AMINOS Study)
Status: RECRUITING
Conditions: Hepatic Steatosis|NAFLD|Adolescent Obesity
Interventions: DRUG: Essential Amino Acid Supplement by Amino Co|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Prunus Mume Extract on Improvement of Constipation
Status: UNKNOWN
Conditions: Constipation
Interventions: DIETARY_SUPPLEMENT: Prunus Mume Extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Multi-Center Study of the Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival
Status: COMPLETED
Conditions: Corneal Neovascularization|Corneal Graft Failure
Interventions: DRUG: Avastin® (bevacizumab)|DRUG: 0.9% NaCl & Refresh Liquigel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pioglitazone to Treat Fatty Liver in Patients With HIV and Hepatitis C Infections
Status: TERMINATED
Conditions: HIV|Hepatitis C|Liver Disease|Fatty Liver|Steatosis
Interventions: DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Need for FibEr Addition in SympTomatic Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DIETARY_SUPPLEMENT: Acacia Gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study to Evaluate the Safety and Efficacy of ATA188 in Subjects With Progressive Multiple Sclerosis
Status: TERMINATED
Conditions: Primary Progressive Multiple Sclerosis|Secondary Progressive Multiple Sclerosis
Interventions: BIOLOGICAL: ATA188|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postprandial Effect of High-starch Meals in Individuals With Low and High Copy Number of the Salivary Amylase Gene
Status: COMPLETED
Conditions: Postprandial Glucose and Insulin Response
Interventions: OTHER: 40 grams of starch|OTHER: 80 grams of starch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of an Alternative Therapeutic Food for the International Food Aid Market to a Standard Ready-to-use Therapeutic Food (RUTF) for the Treatment of Severe Acute Malnutrition in Children
Status: COMPLETED
Conditions: Malnutrition
Interventions: DIETARY_SUPPLEMENT: Alternative RUTF|DIETARY_SUPPLEMENT: Standard RUTF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cleansing of Suction Blood in Cardiac Surgery for Reduced Inflammatory Response
Status: TERMINATED
Conditions: Systemic Inflammatory Response Syndrome|Coronary Arteriosclerosis
Interventions: PROCEDURE: Cell saver|PROCEDURE: No cell saver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HRS3797 in Healthy Subjects
Status: COMPLETED
Conditions: Skeletal Muscle Relaxation
Interventions: DRUG: HRS3797|DRUG: HRS3797|DRUG: HRS3797
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma
Status: RECRUITING
Conditions: Low-Grade Glioma|Recurrent Low-Grade Glioma|Progressive Low-Grade Glioma
Interventions: DRUG: Mirdametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Additional Role of Supplemental Oxygen Therapy in Accelerated Corneal Collagen Cross-linking in Progressive Keratoconus. A Randomized Clinical Trial
Status: UNKNOWN
Conditions: Keratoconus
Interventions: PROCEDURE: perform corneal collagen cross linking accelerated and delivery of systemic oxygen|PROCEDURE: perform corneal collagen cross linking accelerated and without additional oxygen therapy|PROCEDURE: perform Conventiona corneal collagen cross linking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study in Intensive Care Patients Regarding the Effect of Inhaled AP-301 After Primary Graft Dysfunction After Lung Transplantation
Status: COMPLETED
Conditions: PGD Primary Graft Dysfunction
Interventions: DRUG: AP-301|DRUG: saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Prophylactic Efficacy of tDCS in Chronic Migraine
Status: COMPLETED
Conditions: Chronic Migraine as Defined by Criteria of International Headache Society (IHS)
Interventions: DEVICE: Transcranial direct current stimulation of the motor cortex|DEVICE: simulation of Transcranial direct current stimulation of the motor cortex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DTI & Tractography in Pediatric Tumor Surgery
Status: UNKNOWN
Conditions: Brain Damage, Chronic|Cerebellar Cognitive Affective Syndrome|Cerebellar Mutism
Interventions: DEVICE: BrightMatter™ products
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Approach of Hemiarthroplasty After Femoral Neck Fracture: Posterolateral or Direct Lateral
Status: COMPLETED
Conditions: Hip Fractures|Surgical Approach|Hemiarthroplasty|Posterolateral|Direct Lateral
Interventions: PROCEDURE: Surgical approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Study With FLT-PET/CT in Patients With Prostate/Other Solid Malignancies Treated With High Dose Axitinib
Status: COMPLETED
Conditions: Solid Malignancies|Metastatic Castrate-resistant Prostate Cancer
Interventions: DRUG: axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Magnesium in Preventing Low Blood Magnesium Levels in Patients With Ovarian Cancer Receiving Carboplatin Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Carcinoma
Interventions: DIETARY_SUPPLEMENT: Dietary Intervention|OTHER: Media Intervention|BEHAVIORAL: Telephone-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Reha Drive: Capacitive Electrocardiography in Car Seat in Cardiological Patients
Status: COMPLETED
Conditions: Cardiac Events
Interventions: OTHER: Capacitive ECG and contactless heart and breathing rate measurements via camera
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Chokeberry to Reduce Cardiovascular Disease Risk in Former Smokers
Status: COMPLETED
Conditions: Cardiovascular Disease|Oxidative Stress
Interventions: DIETARY_SUPPLEMENT: Chokeberry Extract|DIETARY_SUPPLEMENT: Placebo capsule|DIETARY_SUPPLEMENT: Chokeberry extract capsule, acute
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Frontline Treatment of Follicular Lymphoma With AtezolizUmab and Obinutuzumab With and Without RadiOtherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Follicular Lymphoma
Interventions: DRUG: Obinutuzumab 25 MG/1 ML Intravenous Solution|DRUG: Atezolizumab 1200 MG/40mL Intravenous Solution|RADIATION: 4 Gy in 2 fractions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LYS228 PK, Clinical Response, Safety and Tolerability in Patients With Complicated Urinary Tract Infection (cUTI)
Status: WITHDRAWN
Conditions: Complicated Urinary Tract Infections
Interventions: DRUG: LYS228|DRUG: Standard of care therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial to Investigate the Efficacy, Pharmacokinetics, Safety and Tolerability of BioChaperone Insulin Lispro in Comparison to Humalog® U-100 in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: BioChaperone insulin lispro|DRUG: Humalog®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate BAY2402234, a Dihydroorotate Dehydrogenase (DHODH) Inhibitor, in Myeloid Malignancies
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: BAY2402234
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Speed of Processing (SoP) Training Plus α-tACS
Status: RECRUITING
Conditions: Cognitive Dysfunction|Mild Cognitive Impairment|tACS|Cognitive Training
Interventions: DEVICE: alpha tACS|BEHAVIORAL: Speed of Processing Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Circadian Intervention to Improve Cardiometabolic Health
Status: RECRUITING
Conditions: Cardiometabolic Syndrome|Type 2 Diabetes|Sleep|Time Restricted Feeding|Lifestyle Factors|Overweight and Obesity|Insulin Sensitivity|Eating Habit|Sleep Hygiene
Interventions: BEHAVIORAL: Circadian Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION