pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Immune Response to a Live-Attenuated Respiratory Syncytial Virus (RSV) Vaccine in RSV-Seronegative Infants and Children
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: RSV LID ΔM2-2 Vaccine|BIOLOGICAL: Placebo Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Physiologic Markers of Cardiometabolic Risk in People With Type 1 Diabetes
Status: RECRUITING
Conditions: type1diabetes|Obesity
Interventions: BIOLOGICAL: Hyperinsulinemic-euglycemic clamp|OTHER: High Fat Mixed Meal Tolerance Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: IMPAACT 2002: Cognitive Behavioral Therapy and Medication Management for Treatment of Depression in US Youth With HIV
Status: COMPLETED
Conditions: HIV|Depression
Interventions: BEHAVIORAL: Health and Wellness Combined Cognitive Behavioral Therapy and a Medication Management Algorithm|BEHAVIORAL: Enhanced Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Regadenoson in Sickle Cell Anemia
Status: COMPLETED
Conditions: Sickle Cell Anemia
Interventions: DRUG: Regadenoson|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of TQ05105 Tablets Combined With TQB3617 Capsules in the Treatment of Myelofibrosis (MF)
Status: RECRUITING
Conditions: Myelofibrosis
Interventions: DRUG: TQ05105 Tablets|DRUG: TQB3617 Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Mobile App in Reducing Therapeutic TAT in an Emergency Department
Status: NOT_YET_RECRUITING
Conditions: Pediatric Emergency Medicine|Therapeutic Turnaround Time
Interventions: DEVICE: PIMPmyHospital (mobile app)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Triple Combinations Against Hookworm Infections in Lao
Status: COMPLETED
Conditions: Hookworm Infection
Interventions: DRUG: Albendazole|DRUG: Pyrantel Pamoate|DRUG: Oxantel Pamoate|DRUG: Mebendazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Periprosthetic Bone Mineral Density Changes After Implantation Of A Short Hip Stem Compared To A Straight Stem
Status: UNKNOWN
Conditions: Osteoarthritis, Hip
Interventions: PROCEDURE: Total Hip Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Lipidomic Characterization in Non-metastatic Breast Cancer Women Undergoing Surgery: a Pilot Study.
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Lipid Cell; Tumor|Nutrition Related Cancer|Body Weight
Interventions: PROCEDURE: Lipidomic analysis for breast cancer patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Capecitabine (Xeloda) in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liver Transplantation After ex Vivo Liver Perfusion
Status: NOT_YET_RECRUITING
Conditions: Liver Transplant; Complications|Transplant; Failure, Liver|Transplant Dysfunction|Transplant; Complication, Rejection|Transplant|Liver Metastases|Liver Cancer
Interventions: PROCEDURE: Liver transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Dexmedetomidine Versus Ketamine on Inflammatory Response and Hemodynamic in Patients
Status: NOT_YET_RECRUITING
Conditions: Haemodynamic Rebound
Interventions: DRUG: Dexmedetomidine|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: The Effects of the Anhepatic Phase Extended by Temporary Portocaval Shunt on Anesthetic Sensitivity and Cognitive Function
Status: COMPLETED
Conditions: Liver Cirrhoses
Interventions: PROCEDURE: Temporary portocaval shunt
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Characterizing Myositis With 68Ga-FAPI PET/CT
Status: RECRUITING
Conditions: Myositis|Idiopathic Inflammatory Myopathies
Interventions: DRUG: 68Ga-FAPI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Changes in Carbohydrate Intake on Glucose Control in Patients With Type 1 Diabetes
Status: RECRUITING
Conditions: Type 1 Diabetes|Diet Intervention|Glucose Control
Interventions: OTHER: diverse carbohydrate diet|OTHER: middle carbohydrate diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical, Virological and Safety Outcomes of a Lopinavir/Ritonavir-Based Regimen in HIV-1 Infected Patients in Routine Clinical Use in China
Status: COMPLETED
Conditions: HIV-1 Infections
Interventions: DRUG: Lopinavir/ritonavir (Kaletra)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: COMPARATIVE ANALYSIS OF INNOVATIVE BONE HEALING TECHNIQUES
Status: UNKNOWN
Conditions: To Assess the Bone Healing in Fracture Mandible Defects
Interventions: PROCEDURE: autograft|PROCEDURE: autograft with addition of concenterated growth factor|PROCEDURE: xenograft with concentrated growth factor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Auricular Concha Electro-acupuncture for the Treatment of Depression
Status: UNKNOWN
Conditions: Depression|Depressive Symptom|Depressive Disorder
Interventions: DEVICE: Auricular vagus nerve stimulation|DRUG: Citalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementing and Sustaining a Sleep Treatment to Improve Community Mental Part 1: Implementation Health Outcomes
Status: COMPLETED
Conditions: Sleep Disorder|Circadian Dysregulation
Interventions: BEHAVIORAL: Standard Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C)|BEHAVIORAL: Adapted Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C)|OTHER: Usual Care Delayed Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Massage and Progressive Relaxation Exercises on Primary Dysmenorrhea
Status: COMPLETED
Conditions: Primary Dysmenorrhea
Interventions: OTHER: progressive relaxation exercises and massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Probiotic Supplementation Among Adults With Recurrent Gastrointestinal Symptoms
Status: COMPLETED
Conditions: Gastrointestinal Symptoms|Bloating|Gas|Indigestion|Abdominal Pain|Defecation Irregularity
Interventions: DIETARY_SUPPLEMENT: Probiotic dietary supplement (Trenev Trio®)|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Optimizing IVF Treatment - the Impact of Time-lapse Culture and Preimplantation Factor (PIF) on Embryo Development.
Status: UNKNOWN
Conditions: In Vitro Fertilization|Assisted Reproductive Techniques
Interventions: PROCEDURE: Day 0 denudation and time lapse culture on IVF-oocytes.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Single Dose Escalation Study to Investigate the Safety, Tolerability and Pharmacokinetics of Intramuscular and Subcutaneous Long Acting GSK1265744 in Healthy Subjects
Status: COMPLETED
Conditions: Infections, Human Immunodeficiency Virus and Herpesviridae
Interventions: DRUG: GSK1265744 injectable suspension|OTHER: Placebo to match injectable suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose:
Clinical trial: Echocardiographic Evaluation of the Change on Pulmonary Blood Flow and Cardiac Function Induced by Capnothorax During One Lung Ventilation
Status: COMPLETED
Conditions: Mediastinal Tumors
Interventions: PROCEDURE: capnothorax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Blood Leukocyte Profiling in Eosinophilic Type 2 Asthma: Influence of Systemic IL-5 Targeting
Status: RECRUITING
Conditions: Asthma
Interventions: BIOLOGICAL: Mepolizumab|DRUG: Standard inhaled corticosteroids (ICS) and long-acting beta 2 agonists (LABA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Twelve Month Study of the Safety of Eszopiclone in Adult Subjects With Insomnia
Status: COMPLETED
Conditions: Primary Insomnia
Interventions: DRUG: eszopiclone 3 mg|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: Human umbilical cord mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fish Skin Compared to Cadaver Skin as Temporary Cover for Full Thickness Burns
Status: COMPLETED
Conditions: Burns
Interventions: DEVICE: Fish skin|DEVICE: Cadaver skin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pelvic Embolisation to Reduce Recurrent Varicose Veins - Primary
Status: UNKNOWN
Conditions: Varicose Veins|Venous Reflux
Interventions: PROCEDURE: transjugular coil embolisation of pelvic veins|PROCEDURE: endovenous treatment of leg varicose veins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in Healthy Volunteers and COPD Patients to Evaluate the Efficacy and Safety of Inhaled TV46017
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease (COPD
Interventions: DRUG: TV46017|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: To Evaluate Efficacy of Belinostat or Pralatrexate in Combination Against CHOP Alone in PTCL
Status: RECRUITING
Conditions: Peripheral T Cell Lymphoma
Interventions: DRUG: Belinostat Injection|DRUG: Pralatrexate Injection|DRUG: CHOP|DRUG: COP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastric Ischemic Preconditioning Before Esophagectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Operable Esophageal Cancer|Embolization of the Left Gastric Artery Prior to Surgery
Interventions: PROCEDURE: Gastric Ischemic Preconditioning Before Esophagectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SpeeDx Ciprofloxacin gyrA Assay for N. Gonorrhoeae Gonococcal Infection
Status: RECRUITING
Conditions: Neisseria Gonorrhoeae Infection
Interventions: DRUG: Ciprofloxacin 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neural Mechanism of Vision Therapy for Patients With Convergence Insufficiency
Status: COMPLETED
Conditions: Convergence Insufficiency
Interventions: BEHAVIORAL: Office Based Vergence and Accommodative Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NAC for Promoting Hematopoietic Recovery in Patients With Acute Myeloid Leukemia After Chemotherapy
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: N-acetyl-L-cysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of a Multi-Drug Regimen for Severe Pulmonary Fibrosis in Hermansky-Pudlak Syndrome
Status: TERMINATED
Conditions: Hermansky-Pudlak Syndrome (HPS)|Pulmonary Fibrosis|Oculocutaneous Albinism|Platelet Storage Pool Deficiency|Metabolic Disease
Interventions: DRUG: Losartan|DRUG: Zileuton|DRUG: N-Acetylcysteine|DRUG: Pravastatin|DRUG: Erythromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dabrafenib, Trametinib, and IMRT in Treating Patients With BRAF Mutated Anaplastic Thyroid Cancer
Status: RECRUITING
Conditions: BRAF NP_004324.2:p.V600E|BRAF V600K Mutation Present|Thyroid Gland Anaplastic Carcinoma
Interventions: DRUG: Dabrafenib|RADIATION: Intensity-Modulated Radiation Therapy|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Trial of Traumatic Brain Injured Patients Randomized in the Prehospital Setting to Either Hypertonic Saline and Dextran Versus Normal Saline
Status: COMPLETED
Conditions: Brain Injuries
Interventions: DRUG: hypertonic saline mixed with dextran|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimized Acute Pain Control With Parecoxib in Uniportal Video-assisted Thoracoscopic Surgery.
Status: COMPLETED
Conditions: Perioperative Care|Chronic Post-operative Pain
Interventions: DRUG: Parecoxib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Portable Oxygen Concentrator (POC) Versus Standard of Care in Long-COVID: Randomized Crossover Exploratory Pilot Study.
Status: COMPLETED
Conditions: COVID-19
Interventions: DEVICE: Inogen One® G4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Incision Versus Conventional Laparoscopic Appendectomy
Status: COMPLETED
Conditions: Acute Appendicitis
Interventions: PROCEDURE: single incision laparoscopic appendectomy|PROCEDURE: conventional laparoscopic appendectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Oral Ibandronate in Osteoporosis
Status: RECRUITING
Conditions: Osteoporosis
Interventions: DRUG: Ibandronate|DRUG: Oral Ibandronate and Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fasting Study of Balsalazide Disodium Capsules 750 mg and Colazal® Capsules 750 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Balsalazide Disodium Capsules 750 mg|DRUG: Colazal® Capsules 750 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Venetoclax + Decitabine vs. "7+3" Induction Chemotherapy in Young AML
Status: ACTIVE_NOT_RECRUITING
Conditions: AML, Adult|Chemotherapy Effect
Interventions: DRUG: Venetoclax|DRUG: Decitabine for Injection|DRUG: Cytarabine|DRUG: Idarubicin|DRUG: Gilteritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Intranasal Naltrexone and Naloxone
Status: COMPLETED
Conditions: Opioid-use Disorder
Interventions: DRUG: Naltrexone|DRUG: Naloxone|DRUG: Naltrexol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selenomethionine in Reducing Mucositis in Patients With Locally Advanced Head and Neck Cancer Who Are Receiving Cisplatin and Radiation Therapy
Status: TERMINATED
Conditions: Chemotherapeutic Agent Toxicity|Mucositis|Radiation Toxicity|Stage III Squamous Cell Carcinoma of the Hypopharynx|Stage III Squamous Cell Carcinoma of the Larynx|Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage III Squamous Cell Carcinoma of the Nasopharynx|Stage III Squamous Cell Carcinoma of the Oropharynx|Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IV Squamous Cell Carcinoma of the Hypopharynx|Stage IV Squamous Cell Carcinoma of the Larynx|Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IV Squamous Cell Carcinoma of the Nasopharynx|Stage IV Squamous Cell Carcinoma of the Oropharynx|Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Xerostomia
Interventions: DIETARY_SUPPLEMENT: selenomethionine|OTHER: placebo|DRUG: cisplatin|RADIATION: radiation therapy|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Single-shot TAP Block vs Continuous TAP Block
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DEVICE: TAP-C|DRUG: TAP-S
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial for Autologus NK Cells Alone or in Combination With Isatuximab as Maintenance for Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: CellProtect|DRUG: Isatuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Higher Neural Changes Following Anticholinergic, Beta 3 Agonist, or Placebo in Patients With Overactive Bladder
Status: COMPLETED
Conditions: Overactive Bladder|Dementia|Lower Urinary Tract Symptoms|Incontinence, Urge
Interventions: DRUG: Anticholinergic|DRUG: Beta-3 Agonists, Adrenergic|DIAGNOSTIC_TEST: Functional magnetic resonance imaging (fMRI)|DIAGNOSTIC_TEST: Rey Auditory Verbal Learning Test (RAVLT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Group Cognitive Behavioural Therapy on Comorbid Insomnia and Depression in Youth
Status: COMPLETED
Conditions: Insomnia|Depression
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy for Insomnia (CBT-I)|BEHAVIORAL: Cognitive Behavioural Therapy for Depression (CBT-D)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety and Efficacy of MEGF0444A in Combination With Carboplatin, Paclitaxel and Bevacizumab in Patients With Advanced or Recurrent Non-Squamous Non-Small Cell Lung Cancer Who Have Not Received Prior Chemotherapy for Advanced Disease (NILE)
Status: COMPLETED
Conditions: Non-Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: MEGF0444A|DRUG: bevacizumab|DRUG: carboplatin|DRUG: paclitaxel|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the French Version of the CIQoL-35 Quality of Life Questionnaire in Adult Cochlear Implant Use.
Status: RECRUITING
Conditions: PROM|Cochlear Hearing Loss|Hearing Loss|Quality of Life
Interventions: OTHER: Questionnaire CIQoL-35
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Donafenib for Recurrent Cervical Cancer
Status: UNKNOWN
Conditions: Targeted Therapy|Chemotherapy|Recurrent Cervical Carcinoma|Metastatic Cervical Carcinoma|Persistent Advanced Cervical Carcinoma|Survival Outcomes|Adverse Effect
Interventions: COMBINATION_PRODUCT: Donafenib combined with paclitaxel and platinum ± PD-1 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-center Investigator Initiated Pilot Study Investigating the Tumor Response of Squamous Cell Carcinoma Lesions in Patients Under Lapatinib Treatment
Status: TERMINATED
Conditions: Squamous Cell Carcinoma
Interventions: DRUG: Lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Desara ® One Single Incision Sling 522 Study
Status: RECRUITING
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: Desara® One Single Incision Sling|DEVICE: Desara® Blue Transobturator Sling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of a New Asasantin Formulation Extended Release (ER) Compared to the Commercially Available Asasantin Formulation (Aggrenox®; Extended Release) in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Asasantin ER, new formulation|DRUG: Asasantin ER, present commercial formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dendritic Cell Vaccination and Docetaxel for Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: BIOLOGICAL: mRNA transfected dendritic cell|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study To Investigate The Potential Drug Drug Interaction (DDI) Between PF-00299804 And Paroxetine In Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Period 1|DRUG: Period 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Supervised Brushing Programme for Intellectual Disabled Students
Status: UNKNOWN
Conditions: Oral Health|Intellectual Disability|Randomized Controlled Trial
Interventions: BEHAVIORAL: 3-month supervised tooth brushing programme|BEHAVIORAL: oral health education talk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Triple H ODC Trial
Status: COMPLETED
Conditions: Hypoxia|Hypothermia, Accidental|Hypercapnia|Avalanche, Landslide, or Mudslide
Interventions: OTHER: blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Compare the Bioavailability, Safety and Tolerability of XM17 in Healthy, Down Regulated Young Women
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: XM17|DRUG: Gonal-f®|DRUG: Zoladex®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography
Status: COMPLETED
Conditions: Sleep Apnea Central|Cheyne-Stokes Respiration|Obstructive Sleep Apnea
Interventions: OTHER: Manipulation of Positive Airway Pressure (PAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Breast Cancer Registry for Participants With Breast Cancer or Characteristics of Hereditary Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Precancerous Condition
Interventions: OTHER: medical chart review|OTHER: questionnaire administration|OTHER: study of socioeconomic and demographic variables|PROCEDURE: Excess human biological tissue|PROCEDURE: quality-of-life assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Ketamine in Depressive Symptoms of Elderly Patients With Visual Impairment.
Status: COMPLETED
Conditions: Depression in Old Age|Ketamine
Interventions: DRUG: Ketamine|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Intranasal Ketamine and Midazolam Mixture for Procedural Sedation in Children With Mental Disabilities:
Status: UNKNOWN
Conditions: Procedural Sedation
Interventions: DRUG: Ketamine + midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: XY-Zone Program Evaluation: A School-Based Dropout Prevention Program for At-Risk Youth
Status: COMPLETED
Conditions: Adolescent Problem Behavior at School|Risk Behavior|Truancy; Socialized
Interventions: BEHAVIORAL: XY-Zone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Use of Breathing Exercise Device and Reading Aloud on Vital Signs
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Breath Shortness
Interventions: DEVICE: PEP Device|OTHER: Reading Aloud
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Evaluate the Safety and Efficacy of Sofosbuvir and Ribavirin in Patients With HCV (Genotype 3) Related Decompensated Cirrhosis
Status: TERMINATED
Conditions: HCV Related Cirrhosis
Interventions: DRUG: Sofosbuvir + Ribavirin 1|DRUG: Sofosbuvir + Ribavirin 2|DRUG: Sofosbuvir + Ribavirin 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Radiotherapy in Combination With TTI-101 in Patients With Borderline Resectable Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: TTI-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Benefit of RUCONEST in Improving Neurological Symptoms in Post COVID-19 Infection
Status: UNKNOWN
Conditions: Post-Viral Fatigue Syndrome|Post-Viral Disorder (Disorder)|Covid19
Interventions: DRUG: Ruconest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate The Efficacy And Safety Of TNX-102 SL In Patients With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: TNX-102 SL|DRUG: Placebo SL Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Vortioxetine and Desvenlafaxine in Adult Patients Suffering From Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Vortioxetine|DRUG: Desvenlafaxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Laser Detection for Bladder Cancer by (Photodynamic) Spectra of Urine
Status: COMPLETED
Conditions: Transitional Cell Carcinoma of the Bladder
Interventions: DRUG: Amino levulinic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Post-Market Study Evaluating the Safety of Infinity DBS System With MR Conditional Labeling
Status: COMPLETED
Conditions: Movement Disorders|Parkinson Disease|Essential Tremor|Tremor|Dystonia
Interventions: DEVICE: Infinity DBS System with MR Conditional labelling (Leads-only configuration)|DEVICE: Infinity DBS System with MR Conditional labelling (Full system configuration)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients
Status: RECRUITING
Conditions: Brain Tumor|Head and Neck Cancer
Interventions: RADIATION: substructure informed planning|OTHER: Neurocognitive Testing|DIAGNOSTIC_TEST: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ARQ-761 Treatment With Gemcitabine/Nab-Paclitaxel Chemotherapy In Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: ARQ-761|DRUG: Gemcitabine|DRUG: nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison Between End-to-side and Side-to-side Anastomosis After Laparoscopic Right Hemicolectomy
Status: UNKNOWN
Conditions: Anastomosis
Interventions: PROCEDURE: ES anastomosis|PROCEDURE: SS anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dendritic Cell Therapy, Cryosurgery, and Pembrolizumab in Treating Patients With Non-Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Aggressive Non-Hodgkin Lymphoma|Indolent Non-Hodgkin Lymphoma|Recurrent Diffuse Large B-Cell Lymphoma|Recurrent Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Non-Hodgkin Lymphoma|Recurrent Primary Mediastinal (Thymic) Large B-Cell Lymphoma|Recurrent T-Cell Non-Hodgkin Lymphoma|Small Lymphocytic Lymphoma
Interventions: PROCEDURE: Cryosurgery|BIOLOGICAL: Dendritic Cell Therapy|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Pneumococcal 13-valent Conjugate Vaccine|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Neuroendocrine Response to Intravenous Infusion of Diclofenac Sodium
Status: COMPLETED
Conditions: Hypopituitarism
Interventions: DRUG: Intravenous Infusion of Diclofenac Sodium|DRUG: Intravenous Infusion of Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Respiratory Muscle Training in Acquired Brain Injury Patients.
Status: NOT_YET_RECRUITING
Conditions: Respiratory Disease|Muscle Weakness|Acquired Brain Injury|Older People--Abuse of|Physical Inactivity
Interventions: DEVICE: Inspiratory muscle training|DEVICE: Expiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy of Sintilimab and Anlotinib as a First-line Treatment in Advanced NSCLC (SUNRISE)
Status: UNKNOWN
Conditions: Carcinoma|Non-small Cell Lung Cancer
Interventions: DRUG: sintilimab plus anlotinib|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Implants Versus One Implant With a Cantilever - a Randomized Controlled Clinical Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Implants
Interventions: PROCEDURE: 1 Implant|PROCEDURE: 2 Implants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Piano Therapy vs. Piano Listening on Manual Dexterity in the Elderly
Status: COMPLETED
Conditions: Aging|Manual Dexterity|Piano Therapy
Interventions: BEHAVIORAL: Piano training (Active)|BEHAVIORAL: Piano Training (Passive)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Prostatitis Collaborative Research Network Clinical Trial- Ciprofloxacin and Tamsulosin
Status: COMPLETED
Conditions: Chronic Prostatitis With Chronic Pelvic Pain Syndrome
Interventions: DRUG: Ciprofloxacin|DRUG: Tamsulosin Hydrochloride|DRUG: Tamsulosin Hydrochloride Placebo|DRUG: Ciprofloxacin placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Spiritual Care in Improving Quality of Life of Patients, Caregivers, and Hospital Staff
Status: COMPLETED
Conditions: Malignant Neoplasm
Interventions: PROCEDURE: spiritual therapy|OTHER: questionnaire administration|OTHER: survey administration|OTHER: counseling intervention|OTHER: psychosocial support for caregiver|PROCEDURE: psychosocial assessment and care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Percutaneous Cholecystostomy in the Management of Acute Cholecystitis.
Status: COMPLETED
Conditions: Acute Cholecystitis|Percutaneous Cholecystostomy
Interventions: OTHER: lithiasic|PROCEDURE: Emergency surgery|PROCEDURE: cholecystectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 1-Methyl-D-Tryptophan in Treating Patients With Metastatic or Refractory Solid Tumors That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: 1-methyl-d-tryptophan|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of Imagery Rehearsal Therapy (IRT) of Nightmares
Status: COMPLETED
Conditions: Nightmares|Anxiety Disorders|Mood Disorders|Personality Disorders
Interventions: BEHAVIORAL: Imagery Rehearsal Therapy (IRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility, Safety and Efficacy of Remote Ischemic Preconditioning for Symptomatic Intracranial Arterial Stenosis in Octogenarians
Status: COMPLETED
Conditions: Bilateral Limb Ischemic Preconditioning|Intracranial Arterial Stenosis
Interventions: DEVICE: bilateral limb ischemic preconditioning (Doctormate, IPC-906X)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Single Oral Dose Study of Atovaquone/Proguanil Hydrochloride Combination Tablets and Atovaquone Suspension
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Atovaquone/proguanil HCL|DRUG: Atovaquone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Liver Transplantation for Non-resectable Perihilar Cholangiocarcinoma
Status: RECRUITING
Conditions: Perihilar Cholangiocarcinoma|Klatskin Tumor|Bile Duct Cancer
Interventions: PROCEDURE: Liver transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Quinoa Milk Fermented With Lactic Acid Bacteria From Foods on Human Oral and Intestinal Flora
Status: COMPLETED
Conditions: Microbial Colonization
Interventions: DIETARY_SUPPLEMENT: fermented quinoa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Evaluating Oral MOA-728 for the Treatment of Opioid-Induced Bowel Dysfunction (OIBD) in Subjects With Chronic Non-Malignant Pain
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: MOA-728
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Multi-domain Intervention Program for Post-stroke Bone Health in Older Adults (BOUNCE)
Status: RECRUITING
Conditions: Bone Loss|Stroke|Geriatrics
Interventions: BEHAVIORAL: BOUNCE Program|BEHAVIORAL: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ReNEW:Phase 3 Study of Efficacy, Safety & Pharmacokinetics of Subcutaneous Injections of Elamipretide in Subjects With Dry Age-Related Macular Degeneration (Dry AMD)
Status: RECRUITING
Conditions: Age Related Macular Degeneration (ARMD)
Interventions: DRUG: Elamipretide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: US Phase I Study of ECT-001-CB in Patients With Sickle-Cell Disease
Status: WITHDRAWN
Conditions: Sickle Cell Disease|Umbilical Cord Blood|Hematopoietic Cell Proliferation
Interventions: BIOLOGICAL: ECT-001-CB (UM171-Expanded Cord Blood Transplant)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apatinib + Ifosfamide and Etoposide for Relapsed or Refractory Osteosarcoma
Status: COMPLETED
Conditions: Effect of Drug|Toxicity, Drug|Secondary Resistance
Interventions: DRUG: Apatinib Mesylate|DRUG: ifosfamide and etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Outcomes After Traumatic Injury: A Goal Management Approach
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: Telephone-Based Goal Management Training|BEHAVIORAL: Telephone-Based Attention-Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IPI-549
Status: UNKNOWN
Conditions: Advanced Solid Tumors (Part A/B/C/D)|Non-small Cell Lung Cancer (Part E)|Melanoma (Part E)|Squamous Cell Cancer of the Head and Neck (Part E)|Triple Negative Breast Cancer (Part F)|Adrenocortical Carcinoma (Part G)|Mesothelioma (Part G)|High-circulating Myeloid-derived Suppressor Cells (Part H)
Interventions: DRUG: IPI-549 (eganelisib)|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy for Insomnia (CBT-I) in Schizophrenia(SLEEPINS)
Status: RECRUITING
Conditions: Insomnia|Schizophrenia|Schizoaffective Disorder
Interventions: BEHAVIORAL: iCBT-I|BEHAVIORAL: GCBT-I
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of ARQ-252 Cream 0.3% in Subjects With Non-Segmental Facial Vitiligo
Status: TERMINATED
Conditions: Vitiligo
Interventions: DRUG: ARQ-252 cream 0.3%|DRUG: ARQ-252 Vehicle cream|DEVICE: NB-UVB phototherapy active treatment|DEVICE: NB-UVB phototherapy sham treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ventilatory Parameters and Inflammatory Responses of Neonates Ventilated by Different Modes of Ventilation
Status: COMPLETED
Conditions: Respiratory Distress, Newborn|Ventilator Induced Lung Injury
Interventions: OTHER: SIMV+VG mode of ventilation (synchronized intermittent mandatory ventilation+volume guarantee)|OTHER: PSV+VG (pressure support ventilation+volume guarantee)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Contrast Enhanced Ultrasound Guidance Biopsy for the Diagnosis of Liver Tumors
Status: UNKNOWN
Conditions: Liver Diseases
Interventions: PROCEDURE: Contrast enhanced ultrasound guided liver biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of an Ocular Bandage Contact Lens for the Treatment of Dry Eye After Cataract Surgery
Status: COMPLETED
Conditions: Cataract|Dry Eye
Interventions: DEVICE: bandage contact lenses|PROCEDURE: phacoemulsification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MiDAS I (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study
Status: COMPLETED
Conditions: Lumbar Spinal Stenosis
Interventions: PROCEDURE: Interlaminar Decompression
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Self-controlled Study of the Effect of Partial Spectral Absence of Visible Light on the Pupil
Status: NOT_YET_RECRUITING
Conditions: Full Spectrum
Interventions: OTHER: full-spectrum light exposure|OTHER: specific spectrum absence light exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RCT to Compare Orlistat and Polyglucosamine for the Management of Overweight and Obesity
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: DRUG: orlistat 60 mg|DEVICE: polyglucosamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Pediatric Idiopathic Scoliosis Surgery
Status: RECRUITING
Conditions: Scoliosis Idiopathic|Scoliosis; Adolescence
Interventions: DRUG: 0.9% sodium chloride|DRUG: Dexamethasone|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Parental Holding on Pain Response in Young Children During Cystometry
Status: COMPLETED
Conditions: Vesico-Ureteral Reflux|Filum Terminale Lipoma
Interventions: BEHAVIORAL: Lying|BEHAVIORAL: Holding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Use of a Brief Phone Call After ED Discharge
Status: COMPLETED
Conditions: Discharge Planning|Emergency Medicine|Geriatrics|Patient Readmission
Interventions: BEHAVIORAL: ED Discharge & Medication Call|BEHAVIORAL: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vitamin D Regulation of Gut Specific B Cells and Antibodies Targeting Gut Bacteria in Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|Ulcerative Colitis|Crohn Disease
Interventions: DRUG: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation (TMS) in Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: DEVICE: Transcranial Magnetic Stimulation (TMS)|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-hospital Morphine Titration : Comparison of 0,05 Versus 0,1 mg/kg
Status: COMPLETED
Conditions: Severe, Acute Pain in a Pre-hospital Setting
Interventions: DRUG: morphine|DRUG: morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of AL-37807 to Treat Open-Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: AL-37807
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab, IRX-2, and Chemotherapy in Triple Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Breast Neoplasms
Interventions: DRUG: Pembrolizumab|DRUG: IRX 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-modality Imaging and Collection of Biospecimen Samples in Understanding Bone Marrow Changes in Patients With Acute Myeloid Leukemia Undergoing TBI and Chemotherapy
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Dual-Energy Computed Tomography|DRUG: Fluorothymidine F-18|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC