pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Novel Stimulation Patterns to Improve the Effectiveness of Spinal Cord Stimulation
Status: NOT_YET_RECRUITING
Conditions: Chronic Pain|Pain, Neuropathic|Neuropathic Pain
Interventions: DEVICE: Spinal Cord Stimulator|DEVICE: Spinal Cord Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: High Tibial Osteotomy With/Without Fulkerson Osteotomy in Knee OA
Status: UNKNOWN
Conditions: Osteoarthritis, Knee|Patellofemoral Disorder
Interventions: PROCEDURE: High Tibial Osteotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Adherence Tool to Manage Narcotic -Addicted HIV Patients
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DRUG: Naltrexone and 2-butanol|DRUG: 2-butanol which is encapsulated (size 3 capsule) plus 50 mg of naltrexone (HCl form)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Vacuum-Assisted Dressings (V-AD) in the Management of Open Chest Wounds
Status: COMPLETED
Conditions: Open Chest Wounds
Interventions: DEVICE: Wound Vacuum-assisted dressing|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing PEEP in Laparoscopic Bariatric Surgery Using Bedside Lung Ultrasound
Status: COMPLETED
Conditions: Atelectasis, Postoperative Pulmonary
Interventions: DEVICE: stepwise PEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of PRS According to Inhalation Agent During LDLT
Status: COMPLETED
Conditions: Liver Transplantation|Postreperfusion Syndrome
Interventions: DRUG: sevoflurane|DRUG: Desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: To Investigate Safety, Tolerability and Pharmacokinetics of TC-5214 in Healthy Male Japanese Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: TC-5214|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Harmony & Health: Feasibility of a Movement Intervention to Improve Psychosocial Wellbeing in Black Adults in Northeast Texas
Status: RECRUITING
Conditions: Psychological
Interventions: BEHAVIORAL: Harmony & Health|BEHAVIORAL: Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Magnetic Nanoparticle Sperm Separation for Teratozoospermia Male and Women Older Than 35 Years
Status: COMPLETED
Conditions: Infertility
Interventions: OTHER: Sperm preparation for ICSI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pragmatic Factorial Cluster Trial of Framing and Comparators for Audit and Feedback
Status: COMPLETED
Conditions: High-risk Prescribing in Nursing Homes
Interventions: BEHAVIORAL: Audit and Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: MPFL Reconstruction With or Without Tibial Tubercle Transfer
Status: RECRUITING
Conditions: Patellar Dislocation
Interventions: PROCEDURE: MPFL reconstruction|PROCEDURE: tibial tubercle transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endothelial Cell Loss and Induced Astigmatism After Wound-directed and Wound-assisted IOL Injection
Status: COMPLETED
Conditions: Cataracts|Cataract Surgery
Interventions: PROCEDURE: Lens insertion during cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of Orismilast in Atopic Dermatitis (ADESOS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Atopic Dermatitis|Skin Diseases
Interventions: DRUG: Orismilast modified release tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Variable Interval Versus Set Interval Aflibercept for DME
Status: COMPLETED
Conditions: Cystoid Macular Edema|Diabetic Macular Edema
Interventions: DRUG: Intravitreal Aflibercept Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reliability And Validity Study Of "The Evaluation Tool For Myofascial Adhesions In Patients After Breast Cancer" In Turkish Language
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Upper Extremity Dysfunction|Tissue Adhesion
Interventions: DIAGNOSTIC_TEST: MAP-BC (Myofascial Adhesions in Patients after Breast Cancer) Evaluation Tool|DIAGNOSTIC_TEST: Patient And Observer Scar Assessment Scale ( Observer Subscale)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Guanfacine Adjunctive Treatment to Atypical Antipsychotics for Cognitive Dysfunction in Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia|Schizoaffective Disorder|Cognitive Impairment
Interventions: DRUG: Guanfacine/Tenex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Strengthening the Hip Abductor in Patients With Knee Osteoarthritis: Randomized Controlled Trial
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Hip Abductor Exercise|OTHER: Hip Aductor Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Recurrent Nerve Monitoring During Aortic Arch Repair
Status: UNKNOWN
Conditions: Recurrent Laryngeal Nerve Injuries|Aortic Arch Hypoplasia
Interventions: DIAGNOSTIC_TEST: Electromyography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Positron Emission Tomography Guided Therapy of Aggressive Non-Hodgkin's Lymphomas
Status: COMPLETED
Conditions: Lymphoma, High-grade
Interventions: DRUG: (R-)CHOP protocol|DRUG: B-ALL protocol|DRUG: (R-)CHOP protocol|DRUG: (R-)CHOP protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Group Therapy Based on the Bio-psycho-social Treatment Approach for Women With Chronic Pelvic and Chronic Belly Pain
Status: RECRUITING
Conditions: Pain, Chronic|Pain, Pelvic|Pain, Abdominal|Depression|Sex Disorder|Endometriosis
Interventions: BEHAVIORAL: Learning of Coping Strategies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Influence of Tidal Volume on Postoperative Pulmonary Function
Status: COMPLETED
Conditions: Pulmonary Function
Interventions: OTHER: Randomized application of intraoperative tidal volume|OTHER: Randomized application of intraoperative tidal volume
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Naltrexone Implant (DLP-160)
Status: COMPLETED
Conditions: Opiod Use Disorder
Interventions: COMBINATION_PRODUCT: Combination Product: Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Knotless Implants as An Alternative for Capsular Closure in Primary Hip Arthroscopy: A Prospective, Multi-Center Study
Status: NOT_YET_RECRUITING
Conditions: Femoro Acetabular Impingement
Interventions: DEVICE: LoopLoc Arm|DEVICE: Control Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacodynamics of AP214 Acetate in Patients Undergoing Cardiac Surgery
Status: TERMINATED
Conditions: Cardiac Surgery|Coronary Artery Bypass Grafting|Valve Surgery|Kidney Injury
Interventions: DRUG: AP214|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 3 Study of Ranolazine in Subjects With Type 2 Diabetes Who Are Inadequately Controlled on Metformin Alone
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Ranolazine|DRUG: Placebo to match ranolazine|DRUG: Metformin|DRUG: Placebo to match metformin|BEHAVIORAL: Diet|BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase IIb Study of IFN-K in Systemic Lupus Erythematosus
Status: TERMINATED
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: IFNα-Kinoid|OTHER: Placebo|OTHER: ISA 51 VG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Zoledronic Acid With Radiotherapy in Pts With Advanced Osteolytic Bone Lesions
Status: COMPLETED
Conditions: Pain|Neoplasm Metastasis|Cancer
Interventions: DRUG: Zoledronic acid in combination with therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacogenetic Study of Warfarin Dosing, "The COUMA-GEN Study"
Status: COMPLETED
Conditions: Atrial Fibrillation|Deep Vein Thrombosis|Pulmonary Embolism
Interventions: DRUG: Standard of care or genotyping dosing of warfarin dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Zenith® p-Branch™: Single-Center Study
Status: COMPLETED
Conditions: Aortic Aneurysm|Abdominal Aortic Aneurysm
Interventions: DEVICE: Endovascular treatment (Zenith® p-Branch™ endovascular graft)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of Tropifexor (LJN452) in Patients With Non-alcoholic Steatohepatitis (NASH)
Status: TERMINATED
Conditions: Non-alcoholic Steatohepatitis (NASH)
Interventions: DRUG: Tropifexor (LJN452)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intervention to Promote Survivor Resilience and Adjustment: Efficacy and Sustainability
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: Resilience/Adjustment Counseling|BEHAVIORAL: Resilience/Adjustment Counseling with Booster Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Avapritinib in the Treatment of Unresectable or Recurrent Metastatic GIST Non-exon18 Mutations of PDGFRA
Status: UNKNOWN
Conditions: Gastrointestinal Stromal Tumors|Unresectable Solid Tumor|Recurrent Metastatic Malignant Neoplasm
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of MCS-2 in the Treatment of Lower Urinary Tract Symptoms
Status: COMPLETED
Conditions: Lower Urinary Tract Symptoms|Benign Prostatic Hyperplasia
Interventions: DRUG: MCS-2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-Label Non-Inferiority Study Evaluating the Efficacy and Safety of Xeomin® in Subjects With Cervical Dystonia Flex
Status: COMPLETED
Conditions: Cervical Dystonia
Interventions: BIOLOGICAL: Xeomin®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study of Iocide Oral Rinse in a Diabetic Population
Status: COMPLETED
Conditions: Diabetes Type 2|Periodontitis
Interventions: DRUG: Frio Mouth Rinse Placebo|DRUG: Frio Mouth Rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Affective and Cognitive Responses to Acute Bouts of Physical Activity and Mindfulness Training
Status: COMPLETED
Conditions: Sedentary Behavior
Interventions: OTHER: Mindfulness Training Alone|OTHER: Acute Physical Activity Alone|OTHER: Acute Physical Activity and Mindfulness Training Together
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Addition of Acetaminophen in Standard PDA Management
Status: WITHDRAWN
Conditions: Patent Ductus Arteriosus
Interventions: DRUG: Intravenous Ibuprofen|DRUG: Intravenous Ibuprofen + Oral Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Continuous Low Serratus Anterior Plane Block in Hepatocellular Carcinoma Surgery
Status: RECRUITING
Conditions: Liver Neoplasms|Postoperative Analgesia|Serratus Anterior Plane Block
Interventions: PROCEDURE: Ultrasound-guided continuous low serratus anterior plane block|PROCEDURE: Ultrasound-guided single serratus anterior plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Study of Aztreonam Lysine for Inhalation (AZLI) in the Treatment of Early Bronchiolitis Obliterans Syndrome (BOS)
Status: COMPLETED
Conditions: Complication of Transplanted Lung
Interventions: DRUG: Aztreonam Lysine for Inhalation (AZLI)|PROCEDURE: Status Post Lung Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ATLCAR.CD30.CCR4 for CD30+ HL ATLCAR.CD30.CCR4 Cells
Status: RECRUITING
Conditions: Hodgkin Lymphoma|Relapse|Refractory
Interventions: DRUG: Chemotherapy|BIOLOGICAL: Cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-human Study of SAR443765 in Healthy Participants and in Asthmatic Participants
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: SAR443765|DRUG: Placebo|DRUG: Salbutamol or levosalbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Immune Therapy, Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Germ Cell Tumor|Nonseminomatous Germ Cell Tumor|Seminoma|Germinomatous Germ Cell Tumor|Dysgerminoma|Pineal Germ Cell Tumor
Interventions: DRUG: Durvalumab|DRUG: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Multi-Center Study of the Bard® Denali™ Retrievable Inferior Vena Cava Filter System
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: DEVICE: Denali inferior vena cava filter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NVA237 Versus Placebo 12-week Efficacy Study
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: NVA237|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fumaric Acid Versus Fumaric Acid Plus Narrow Band Type B Ultraviolet (UVB) for Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DEVICE: Full Body UV Therapy System UV 7002 plus fumaric acid esters|DRUG: Fumaric acid esters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of SY-5007, a RET Inhibitor, in Patients With RET-altered Advanced Solid Tumor
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer|Medullary Thyroid Cancer|Solid Tumor
Interventions: DRUG: SY-5007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Soft Tissue Assessment in Screw-Retained Maxillary Complete Denture With Electric Welded Framework Versus Casted
Status: UNKNOWN
Conditions: Peri-Implantitis
Interventions: DEVICE: Electric intraoral welding device|DEVICE: casting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Computer Aided Design and 3D Printing for Anesthesiology Management in a Pediatric Patient With Cleft Facial Defect (3D Obturator) - Pilot Trial
Status: UNKNOWN
Conditions: Cleft Lip and Palate
Interventions: DEVICE: 3D Obturator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: EUS-guided PORtal Vein Sampling for Circulating Tumor Cells in Pancreatic Cancer Patients
Status: RECRUITING
Conditions: Pancreatic Cancer|Pancreatic Adenocarcinoma
Interventions: PROCEDURE: EUS-guided Portal Vein sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Carfilzomib, Lenalidomide, Vorinostat, and Dexamethasone in Relapsed and/or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Vorinostat, Lenalidomide, Carfilzomib, Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-Arm Study Evaluating the Efficacy of Liquid Acupuncture Therapeutics in Chronic Hepatitis B
Status: UNKNOWN
Conditions: Hepatitis B, Chronic|Liver Diseases|Virus Diseases|Hepatitis|Diffuse Hepatic Disease
Interventions: DEVICE: Liquid Acupuncture (Herb Acupoint Injection)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Presurgical Trial of REGN5678 (Anti-PSMA x CD28) in Patients With High-risk, Localized Prostate Cancer Followed by Radical Prostatectomy
Status: RECRUITING
Conditions: Prostate Cancer|Radical Prostatectomy
Interventions: DRUG: REGN5678|DRUG: Piflufolastat F18
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Naltrexone in Achieving and Maintaining Abstinence From Alcohol in Patients With Cirrhosis.
Status: COMPLETED
Conditions: Liver Cirrhosis
Interventions: DRUG: Naltrexone|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Extension (Rollover) Study of Vemurafenib in Participants With BRAF V600 Mutation-Positive Malignancies Previously Enrolled in an Antecedent Vemurafenib Protocol
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Tislelizumab With Split-course HFRT for Locally Advanced Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer|Radiation Oncology
Interventions: RADIATION: split-course HFRT|DRUG: CAPOX chemotherapy|DRUG: Tislelizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of HyQvia in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) in Routine Clinical Care
Status: NOT_YET_RECRUITING
Conditions: Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
Interventions: OTHER: No Intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Complete Easy Rub Comparative Efficacy Study
Status: WITHDRAWN
Conditions: Myopia|Hyperopia|Astigmatism
Interventions: DEVICE: Complete Easy Rub Formula MPS|DEVICE: Aquify MPS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study of Sumatriptan Naproxen Sodium Succinate Tablets for the Treatment of Acute Migraine Attacks
Status: UNKNOWN
Conditions: Migraine in Adults
Interventions: DRUG: sumatriptan 85mg and naproxen sodium 500mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of the Safety and Efficacy of Face Talc Slurry and Iodopovidone for Pleurodesis
Status: UNKNOWN
Conditions: Malignant Pleural Effusions|Recurrent Pleural Effusions|Primary Spontaneous Pneumothorax|Secondary Spontaneous Pneumothorax
Interventions: PROCEDURE: Pleurodesis with either talc or iodopovidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TREATment of Lower Respiratory Tract Infection in Sri Lanka (TREAT-SL)
Status: NOT_YET_RECRUITING
Conditions: Lower Resp Tract Infection
Interventions: OTHER: electronic clinical decision support tool (eCDST) diagnostic plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Procalcitonin to Reduce Antibiotic Use in Pediatric Pneumonia
Status: COMPLETED
Conditions: Pneumonia|Pediatric Respiratory Diseases|Antibiotic Use|Community-acquired Pneumonia
Interventions: DRUG: Amoxicillin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Drug-Drug Interaction Study of ALKS 5461 in Healthy Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Itraconazole|DRUG: ALKS 5461
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Fimasartan Versus Amlodipine Therapy on Carotid PlaquE Inflammation
Status: COMPLETED
Conditions: Inflammation Plaque, Atherosclerotic|Coronary Disease|Renin-Angiotensin System
Interventions: DRUG: 6-month treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Netarsudil (AR-13324) Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Ocular Hypertension|Glaucoma
Interventions: DRUG: AR-13324 Ophthalmic Solution 0.02%|DRUG: AR-13324 Ophthalmic Solution 0.02% BID|DRUG: Timolol maleate Ophthalmic Solution 0.5% BID|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Novel Questionnaire to Assess Patient Satisfaction With and Preference of Intranasal Corticosteroids for the Treatment of Allergic Rhinitis
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis
Interventions: DRUG: ciclesonide hydrofluoroalkane (HFA) nasal aerosol|DRUG: mometasone nasal inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: CD22-CAR T Cells in Children and Young Adults With B Cell Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: B Cell Lymphoma|Acute Lymphoblastic Leukemia, Pediatric|Lymphoma
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Autologous CD22 CAR T
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biodynamic Imaging Utility in Predicting Response to Gemcitabine Chemotherapy in Mycosis Fungoides
Status: TERMINATED
Conditions: Lymphoma, T-Cell, Cutaneous|Mycosis Fungoides
Interventions: DIAGNOSTIC_TEST: Biodynamic imaging (BDI) of mycosis fungoides
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Early Oseltamivir Carboxylate Low Plasma Concentration in Patients Admitted to Intensive Care for Severe Influenza
Status: NOT_YET_RECRUITING
Conditions: Severe Influenza
Interventions: OTHER: Absorption test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effectiveness of Skit Video to Improve Oral Hygiene Status of Children With Hearing Impairment
Status: COMPLETED
Conditions: Hearing Impaired Children
Interventions: BEHAVIORAL: Skit video, Pictorial, Sign language
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RCT :Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb
Status: UNKNOWN
Conditions: Complex Regional Pain Syndrome I of Upper Limb
Interventions: PROCEDURE: thoracic sympathetic block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Chewing Gum, Exercises of the Tongue, Lip, Jaw on Salivation, Xerostomia, Dysphagia in Sjögren's Syndrome
Status: COMPLETED
Conditions: Sjögren's Syndrome|Xerostomia|Dysphagia|Salivary Flow Rate
Interventions: BEHAVIORAL: Tongue, lip, chin exercise group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial of Standard vs Half Dose Rabeprazole, Clarithromycin, Metronidazole and Amoxicillin in the Treatment of Helicobacter Pylori Infection
Status: COMPLETED
Conditions: Helicobacter Infections
Interventions: DRUG: Rabeprazole, metronidazole, Clarithromycin, Amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Sleep Apnea|Sleep-disordered Breathing
Interventions: DEVICE: Positive Pressure Therapy (PAP)|BEHAVIORAL: LifeStyle Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Community-Based Interventions on Increasing Family Planning Utilization in Pastoralist Community
Status: COMPLETED
Conditions: Family Size
Interventions: BEHAVIORAL: Women Education|BEHAVIORAL: Male Involvement|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Assess Amphotericin B Cystetic for Inhalation (ABCI) Doses in Healthy Volunteers & People With Cystic Fibrosis
Status: RECRUITING
Conditions: Cystic Fibrosis
Interventions: COMBINATION_PRODUCT: ABCI|COMBINATION_PRODUCT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Larotaxel + Cisplatin Versus Gemcitabine + Cisplatin in First Line Treatment of Locally Advanced/Metastatic Urothelial Tract or Bladder Cancer
Status: COMPLETED
Conditions: Urinary Bladder Neoplasms
Interventions: DRUG: larotaxel (XRP9881)|DRUG: gemcitabine|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DCVax Plus Poly ICLC in Healthy Volunteers
Status: COMPLETED
Conditions: HIV-1 Infection|HIV Infection|Healthy Volunteers
Interventions: DRUG: DCVax-001|DRUG: Poly-ICLC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression
Status: COMPLETED
Conditions: Treatment-resistant Depression
Interventions: DRUG: Esketamine|DRUG: Placebo|DRUG: Duloxetine (Oral Antidepressant)|DRUG: Escitalopram (Oral antidepressant)|DRUG: Sertraline (Oral Antidepressant)|DRUG: Venlafaxine Extended Release (XR) (Oral Antidepressant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cerebral Metabolic Changes Associated With Thalamic Stimulation
Status: TERMINATED
Conditions: Epilepsy
Interventions: PROCEDURE: Positron Emission Tomography (PET) Scan|PROCEDURE: Magnetic Resonance Imaging (MRI)|OTHER: Neuropsychological Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erlotinib Versus Carboplatin/Vinorelbine in Elderly Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)
Status: UNKNOWN
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Erlotinib|DRUG: Vinorelbine and Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrated Treatment for Co-occurring Eating Disorders and Posttraumatic Stress Disorder
Status: COMPLETED
Conditions: PostTraumatic Stress Disorder|Eating Disorder
Interventions: BEHAVIORAL: CBT for ED|BEHAVIORAL: Concurrent CBT for ED and PTSD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multimodal Prehabilitation for Colorectal Surgery
Status: COMPLETED
Conditions: Colorectal Cancer|Colorectal Cancer Stage III
Interventions: BEHAVIORAL: multimodal prehabilitation|BEHAVIORAL: multimodal prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extinction Learning in Adults With Tourette Syndrome
Status: COMPLETED
Conditions: Tourette Syndrome|Habit Reversal Training|Tic Disorders|Tics|Comprehensive Behavioral Intervention for Tics
Interventions: BEHAVIORAL: Habit Reversal Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Evaluation of Repeat neoGAA Dosing in Late Onset Pompe Disease Patients.
Status: COMPLETED
Conditions: Pompe Disease|Glycogen Storage Disease Type II (GSD II)|Acid Maltase Deficiency
Interventions: DRUG: GZ402666
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AScVS and/ or Prazosin for Scorpion Envenomation
Status: COMPLETED
Conditions: Scorpion Envenomation
Interventions: DRUG: Antiscorpion venom serum(AScVS).|DRUG: T.Prazosin|DRUG: AScVS + Prazosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Establish Whether the Use of T-Tube in Bile Duct Anastomosis in Liver Transplantation Decreases Morbidity
Status: COMPLETED
Conditions: Evidence of Liver Transplantation
Interventions: DEVICE: Choledocho-choledochostomy with T-tube|DEVICE: Choledocho-choledochostomy without T-tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients With Cancer
Status: COMPLETED
Conditions: Kidney Cancer|Leukemia|Lymphoma|Neurotoxicity|Peripheral Neuropathy|Sarcoma
Interventions: DRUG: glutamic acid|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination of Nicotine Replacement Therapy (NRT) and Varenicline to Increase Cessation of Tobacco (CONVICT Study)
Status: COMPLETED
Conditions: Tobacco Dependence|Smoking Cessation
Interventions: DRUG: Nicotine Patch|DRUG: Placebo|DRUG: Varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ev-AIFIB Preliminary Evaluation of the AIFib Software
Status: COMPLETED
Conditions: Software Performance Evaluation a Posteriori
Interventions: DIAGNOSTIC_TEST: the intraoperative effectiveness of the AIFIB software in real time in the detection of atrial fibrillation drivers during an ablation procedure.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Nasal Cannula During the First 2 Hours Postoperative in Patient Undergoing Thoracotomy
Status: COMPLETED
Conditions: Lung Surgery|Hypoxia|Postoperative
Interventions: DEVICE: oxygen cannular
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label, Single-arm Study to Assess the Pharmacokinetics, Safety, and Tolerability of a Single Subcutaneous Dose of Icatibant in Healthy Japanese Volunteers
Status: COMPLETED
Conditions: Hereditary Angioedema (HAE)
Interventions: DRUG: Icatibant (30 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Urgent PC Versus Sham Effectiveness in Treatment of Overactive Bladder Symptoms
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DEVICE: Urgent PC Neuromodulation System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effectiveness of an Acceptance and Commitment Therapy-based Group Intervention for Parents of Children With a Diagnosis of Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: START programme|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Mind-Body Intervention for Diabetes Management: A Pilot Study
Status: COMPLETED
Conditions: Diabetes Mellitus|Stress, Psychological|Stress, Physiological
Interventions: BEHAVIORAL: Stress Management and Resiliency Training (SMART) program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of the Combination of Simeprevir and Daclatasvir in Chronic Hepatitis C Genotype 1b-Infected Participants
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Simeprevir|DRUG: Daclatasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Self-Exclusion Procedure Optimized by an Extension of the Suspension of Commercial Solicitations
Status: RECRUITING
Conditions: Gambling Disorder
Interventions: OTHER: optimized self-exclusion procedure by extending the suspension of commercial solicitations for a total of 9 months
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: mulTi-Arm Therapeutic Study in Pre-ICu Patients Admitted With Covid-19 - Repurposed Drugs (TACTIC-R)
Status: UNKNOWN
Conditions: COVID19
Interventions: DRUG: Ravulizumab|DRUG: Baricitinib|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long Term Study of Intermittent Oral Dosing of ASP1517 in Hemodialysis Chronic Kidney Disease Patients With Anemia Converted From Erythropoieses Stimulating Agent (ESA) Treatment
Status: COMPLETED
Conditions: Hemodialysis Patients With Renal Anemia
Interventions: DRUG: roxadustat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Hematopoietic Stem Cell Transplantation With Ixazomib for High Risk Multiple Myeloma (BMT CTN 1302)
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: PROCEDURE: Allogeneic HSCT|DRUG: Fludarabine|DRUG: Melphalan|DRUG: Bortezomib|DRUG: Ixazomib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Dentin Graft and I-PRF With and Without Vitamin C for Post-extraction Socket Preservation
Status: RECRUITING
Conditions: Socket Preservation
Interventions: PROCEDURE: Alveolar ridge preservation using autogenous demineralized dentin graft and i-PRF|PROCEDURE: Alveolar ridge preservation using vitamin C with dentin graft and i-PRF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ginkgo Biloba Capsule on Visual Function of Primary Open-angle Glaucoma With Blood Stasis Syndrome
Status: UNKNOWN
Conditions: Primary Open Angle Glaucoma|Drug Effect
Interventions: DRUG: Ginkgo biloba capsule|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Sucralose in Insulin Sensitivity
Status: COMPLETED
Conditions: Insulin Sensitivity/Resistance
Interventions: OTHER: Sucralose|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of Rituximab to Treat Chronic Renal Transplant Rejection
Status: COMPLETED
Conditions: Kidney Transplantation|Graft Rejection|Immunosuppression
Interventions: DRUG: Rituximab|OTHER: Control arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of a Breath-operated Albuterol Inhaler in Asthma Patients With Poor Inhaler Technique
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Albuterol HFA-BOI|DRUG: Albuterol HFA-MDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aesthetic Performance and Tolerance of an Injective Intradermal Treatment for the Skin Roughness and Laxity of Back of the Hands
Status: COMPLETED
Conditions: Skin Laxity|Skin Roughness
Interventions: DEVICE: Profhilo® Body
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Better Acceptance of Single Injection Apidra Added to Once Daily Lantus Versus Twice Daily Premixed Insulin in Real Life Use Setting
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin glulisine|DRUG: Insulin glargine|DRUG: Premixed insulin (Insulin Aspart 30/70 )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sodium Oxybate in Patients With Alternating Hemiplegia of Childhood (AHC-SO)
Status: COMPLETED
Conditions: Alternating Hemiplegia of Childhood
Interventions: DRUG: Sodium Oxybate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ergogenic and Antioxidant Effects of Corinthian Currant
Status: COMPLETED
Conditions: Athletic Performance|Oxidative Stress|Inflammation
Interventions: DIETARY_SUPPLEMENT: Corinthian currant|DIETARY_SUPPLEMENT: Glucose drink|DIETARY_SUPPLEMENT: Water ingestion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Parent and Child Emotions in Fetal Alcohol Spectrum Disorder (FASD)
Status: COMPLETED
Conditions: Fetal Alcohol Spectrum Disorders
Interventions: BEHAVIORAL: Tuning In to kids intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics Study of Bryostatin 1 in Patients With Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer's Disease
Interventions: DRUG: Bryostatin for Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Meibomian Gland Dysfunction and Dry Eye in Contact Lens Wearers
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction|Dry Eye
Interventions: DEVICE: LipiFlow treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Absolute Bioavailability and Metabolism Study of CORT118335 in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CORT118335 Oral|DRUG: 14C-CORT118335 intravenous|DRUG: 14C-CORT118335 oral
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness Study During the First 1,000 Days in Kenya
Status: COMPLETED
Conditions: Stunting|Anemia|Micronutrient Deficiency
Interventions: DIETARY_SUPPLEMENT: Intervention (integrated package)|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Study on the Effect of Oral Controlled-Release Alpha-Lipoic Acid on Oxidative Stress in Adolescents With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: controlled-release oral alpha-lipoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D on Ventricular Remodeling in Patients With Acute Myocardial Infarction (VITDAMI)
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: Calcifediol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NOX1416 in Treatment of Chronic Non-Healing Diabetic Foot Ulcers (NTCDU)
Status: SUSPENDED
Conditions: Diabetic Foot Ulcer
Interventions: DRUG: NOX-1416+SOC|OTHER: Placebo+SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interdisciplinary Hospital-home Intervention on Motor Development in Premature Children
Status: UNKNOWN
Conditions: Premature Birth
Interventions: OTHER: Interdisciplinary hospital-home intervention|OTHER: Convencional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Curcumin Supplementation in Middle-Aged and Older Adults Improves Vascular Function
Status: UNKNOWN
Conditions: Vascular Aging
Interventions: DRUG: Placebo pill|DRUG: High-dose curcumin pill|DRUG: Low-dose curcumin pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Combination Thalidomide Plus Dexamethasone Therapy vs. Dexamethasone Therapy Alone in Previously Untreated Subjects With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: A (Thalidomide + Dexamethasone)|DRUG: B (Placebo + Dexamethasone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transversus Abdominis Plane Blocks With Abdominoplasty
Status: UNKNOWN
Conditions: Post Operative Pain
Interventions: DRUG: Ropivacaine 0.25%, 0.5 ml/kg|DRUG: Ropivacaine 0.25%, 0.5 ml/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Application of Thrombin Gel Matrix for the Prevention of Lymphocele in Patients With Endometrial Cancer.
Status: COMPLETED
Conditions: Lymphocele|Lymphocele After Surgical Procedure|Endometrium Cancer
Interventions: DRUG: Thrombi-Gel|PROCEDURE: Conventional Pelvic lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION