pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Finerenone and Renal Oxidative Stress
Status: RECRUITING
Conditions: Type2diabetes
Interventions: DRUG: Finerenone 20 MG Oral Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate How Well Single and Multiple Doses of GLPG3121-modified Release Formulation Are Tolerated in Healthy, Adult Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG3121|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: TWIN2WIN (Double Stent (DS-EVT) Versus Primary Thrombectomy With One Stent (SS-EVT))
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DEVICE: Thrombectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Predictive Value of Ariscat Index In The Development of Pulmonary Complication After Major Abdominal Cancer Surgery
Status: COMPLETED
Conditions: Postoperative Complications|Cancer|Pulmonary Complication|Atelectasis|Abdominal Surgery|Pneumonia
Interventions: DIAGNOSTIC_TEST: Detection / Screening
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Expert Guiding Technology to Help Individuals With Developmental Challenges Build Life and Vocational Skills
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Intellectual Disability
Interventions: BEHAVIORAL: Use of Expert Guiding Technology (GAINS) to Improve Live and Vocational Skills for Individuals with Developmental Challenges
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effect of Isometric Exercise on Blood Pressure in Hypertensive Patients
Status: UNKNOWN
Conditions: Arterial Hypertension
Interventions: OTHER: isometric handgrip exercise|OTHER: isometric of the lower limbs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Lighting Intervention on Sleep in Parkinson Disease
Status: RECRUITING
Conditions: Parkinson Disease|Sleep Disturbance
Interventions: DEVICE: Tailored Lighting Intervention (TLI)|DEVICE: Actigraph
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total Knee Replacement With the Attune vs. the Press Fit Condylar (PFC) Sigma.
Status: UNKNOWN
Conditions: Osteoarthrosis, Knee
Interventions: PROCEDURE: Total Knee Replacement (2 different design)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Busulfan, Etoposide, Cytarabine, and Melphalan (BuEAM) Conditioning for Autologous Stem Cell Transplantation (ASCT) to Treat T Cell or Natural Killer (NK) Cell Lymphoma
Status: UNKNOWN
Conditions: Non-Hodgkin Lymphoma
Interventions: DRUG: Busulfan, etoposide, cytarabine, and melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Aerobic Exercise on Stress and Fatigue of Lactating Employed Women
Status: UNKNOWN
Conditions: Stress|Fatigue
Interventions: OTHER: Aerobic exercise|OTHER: Traditional Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Left Atrial Appendage Closure With WATCHMAN FLX Device in Recurrent Gastrointestinal Bleeding: The GI-FLX Registry
Status: RECRUITING
Conditions: Atrial Fibrillation|GI Bleeding
Interventions: DEVICE: LAAC with Watchman FLX device
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Investigate the Efficacy of an Occluding Dentifrice in Providing Relief From Dentine Hypersensitivity
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: OTHER: Stannous Fluoride Dentifrice|OTHER: Sodium monofluorophosphate Dentifrice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety of Axicabtagene Ciloleucel Reinfusion (Axi-Cel-2) in Patients With Relapsed and/or Refractory Second Line High-Risk Non-Hodgkin Lymphoma After Standard of Care Axi-Cel
Status: RECRUITING
Conditions: Non-Hodgkin Lymphoma|Large B-cell Lymphoma
Interventions: DRUG: Axicabtagene Ciloleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous (IV) Nitroglycerin for Versions in Multiparous Women
Status: COMPLETED
Conditions: Breech Presentation|Pregnancy Complication
Interventions: DRUG: IV Nitroglycerin|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EPO906 Plus Radiation Therapy for the Treatment of Cancer Patients
Status: COMPLETED
Conditions: Central Nervous System Neoplasms|Head and Neck Neoplasms
Interventions: DRUG: EPO906 (epothilone B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zero Fluoroscopy Voltage Guided vs. Linear CTI Ablation
Status: RECRUITING
Conditions: Catheter Ablation|Atrial Flutter Typical|Radiation Exposure
Interventions: PROCEDURE: HR electroanatomic mapping and MVG catheter ablation|PROCEDURE: Conventional bipolar mapping and linear catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Compare Prophylaxis Therapy to On-demand Therapy With a New Full Length Recombinant FVIII in Patients With Severe Hemophilia A
Status: COMPLETED
Conditions: Hemophilia A
Interventions: BIOLOGICAL: rFVIII (BAY81-8973) on demand|BIOLOGICAL: rFVIII (BAY81-8973) prophylaxis low-dose|BIOLOGICAL: rFVIII (BAY81-8973) prophylaxis high-dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transitioning to a Valve -Gated Intrathecal Drug Delivery System (IDDS)
Status: WITHDRAWN
Conditions: Chronic Pain|Intractable Pain|Back Pain
Interventions: DEVICE: Prometra II Programmable Pump system(Flowonix Medical)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ciclesonide vs Fixed Combination of Fluticasone Propionate/Salmeterol vs Placebo in Patients With Mild Persistent Asthma (12 to 75 y) (BY9010/M1-132)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Ciclesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Exogenous Effects of Standard Medical Care (Dopamine) on Motor Learning of an Upper Limb Task in Parkinson Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: Upper limb feeding training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Escalating Single Dose Study of Epsi- Gam in Healthy Normal Subjects
Status: TERMINATED
Conditions: Allergy and Immunology
Interventions: DRUG: 0.1 mg/kg epsi-gam or placebo (6:2)|DRUG: 0.3 mg/kg epsi-gam or placebo (6:2)|DRUG: 1.0 mg/kg epsi-gam or placebo (6:2)|DRUG: 3 mg/kg epsi-gam or placebo (6:2)|DRUG: 10 mg/kg epsi-gam or placebo (6:2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Roflumilast at Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease With (Acute) Exacerbation
Interventions: DRUG: Roflumilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of ZD1839 and Tamoxifen in Patients With Epithelial Ovarian Carcinoma, Cancer of the Fallopian Tube or the Peritoneum Refractory to Platinum- and Taxane-based Therapy
Status: COMPLETED
Conditions: Ovarian Cancer|Cancer of the Fallopian Tube|Peritoneal Cancer
Interventions: DRUG: ZD1839|DRUG: tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myopia Control With Three Lever Irradiance of PBM Therapy in Children and Adults
Status: COMPLETED
Conditions: Myopia|Amblyopia|Refractive Error - Myopia Axial|Ametropia
Interventions: DEVICE: Airdoc device of red light for Myopia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GAD-M Regimen As First-Line Treatment in Untreated Extranodal NK/T Cell Lymphoma
Status: UNKNOWN
Conditions: Extranodal NK/T-cell Lymphoma, Nasal Type
Interventions: DRUG: High dose of methotrexate|DRUG: Gemcitabine|DRUG: Pegaspargase|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Single Dose Intrathecal Dexmedetomidine for Postoperative Analgesia
Status: UNKNOWN
Conditions: Lower Limb Surgery
Interventions: DRUG: Intrathecal dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Postoperative Pain and Morphine Consumption After Mastectomy - Lyrica
Status: COMPLETED
Conditions: Post-operative Pain
Interventions: DRUG: lyrica
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 61Cu-NODAGA-LM3 PET/CT for the Detection of Neuroendocrine Tumors (COPPER PET in NET)
Status: NOT_YET_RECRUITING
Conditions: Neuroendocrine Tumors
Interventions: DRUG: 61Cu-NODAGA-LM3|OTHER: Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Intravenous Paracetamol Versus Ketoprofen When Treating Renal Colic in Emergency Situations
Status: WITHDRAWN
Conditions: Renal Colic|Acute Renal Colic
Interventions: DRUG: Intravenous ketoprofen|DRUG: Intravenous paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Perampanel in Combination in Glioma-refractory Epilepsy
Status: WITHDRAWN
Conditions: Refractory Epilepsy
Interventions: DRUG: Perampanel|DRUG: conventional antiepileptic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Automated Determination of Insulin Pump Setting for Subjects With Type 1 Diabetes Switching From MDI to Pump Therapy and Vice Versa- Safety and Efficacy Feasibility Study
Status: COMPLETED
Conditions: Type1diabetes
Interventions: DEVICE: MD-Logic Switch Advisor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Performance Comparison of the 25 Gauge 20,000cpm HYPERVIT Dual Blade vs. 10,000cpm ULTRAVIT Vitrectomy Cutter
Status: COMPLETED
Conditions: Vitrectomy|Epiretinal Membrane|Macular Hole|Vitreous Hemorrhage|Retinal Detachment
Interventions: DEVICE: 25 gauge 20,000 cpm Hypervit Dual Blade|DEVICE: 25 gauge 10,000 cpm Ultravit Vitrectomy Cutter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: AI in Outpatient Practice for Diagnosing Aortic Stenosis and Diastolic Dysfunction
Status: NOT_YET_RECRUITING
Conditions: Aortic Stenosis|Diastolic Dysfunction
Interventions: DEVICE: AI-ECG Dashboard|DIAGNOSTIC_TEST: Point of care ultrasound (POCUS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Motivational Interviewing and Neuroimaging With Adolescents
Status: COMPLETED
Conditions: Alcohol Use, Unspecified
Interventions: BEHAVIORAL: Motivational Interviewing (MI)|BEHAVIORAL: Brief Adolescent Mindfulness (BAM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sorafenib and TACE as Adjuvant Therapy for MVI in HCC Patients After Radical Resection
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Sorafenib|PROCEDURE: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemigliptin-Rosuvastatin Fix-dose Combination Phase 3(BALANCE)
Status: COMPLETED
Conditions: Type 2 Diabetes|Dyslipidemia
Interventions: DRUG: Gemigliptin and/or Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Vagus Nerve Stimulation on Cycling Ergometry and Recovery
Status: COMPLETED
Conditions: Healthy|Sports Physical Therapy|Activity, Motor
Interventions: DEVICE: Unilateral Stimulation|DEVICE: Bilateral Stimulation|DEVICE: Bilateral Sham Stimulation|DIAGNOSTIC_TEST: Bicycle Ergometer Test|DIAGNOSTIC_TEST: Lactat Scout|DIAGNOSTIC_TEST: Polar H10|DEVICE: Vagustim Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Esketamine DPI - low dose|DRUG: Esketamine DPI - medium dose|DRUG: Esketamine DPI - high dose|DRUG: Placebo DPI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Belotecan and Cisplatin in Treating Patients With Previously Untreated, Extensive-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: belotecan hydrochloride|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lumiliximab in Combination With FCR in Subjects With Relapsed Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Lumiliximab with FCR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Laparoscopic Pectopexy and Laparoscopic Lateral Suspension Techniques in Uterine-preserving Apical Prolapsus Repair
Status: COMPLETED
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: LLS versus LP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Titration of Lisinopril in Children Aged 1 to 18 Years With Primary or Secondary Hypertension
Status: COMPLETED
Conditions: Primary Hypertension|Secondary Hypertension
Interventions: DRUG: lisinopril, ACE-inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis
Status: RECRUITING
Conditions: Generalized Myasthenia Gravis
Interventions: DRUG: Pozelimab + Cemdisiran|DRUG: Cemdisiran|OTHER: Placebo|DRUG: Pozelimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Psoriasis Plaque Test Trial With LP0113 Spray in Patients With Psoriasis Vulgaris (LP0113-1123)
Status: COMPLETED
Conditions: Skin and Connective Tissue Diseases
Interventions: DRUG: LP0113 aerosol spray|DRUG: Aerosol spray vehicle|DRUG: LEO 90100 aerosol foam|DRUG: Betamethasone dipropionate aerosol spray|DRUG: Calcipotriol aerosol spray|DRUG: Daivobet® gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.
Status: NOT_YET_RECRUITING
Conditions: Candidemia|Candidiasis, Invasive
Interventions: DRUG: Fosmanogepix|DRUG: Fosmanogepix|DRUG: Caspofungin|DRUG: Fluconazole|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY2157299 in Participants With Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: LY2157299|DRUG: Sorafenib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of MoodRing on Improving the Quality of Depression Management in Adolescents
Status: COMPLETED
Conditions: Depression in Adolescence
Interventions: DEVICE: MoodRing App|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: CFT-focused Mental Health Intervention With Exposure Training for Youngsters
Status: RECRUITING
Conditions: Conduct Disorder|Psychopathic Personality Trait
Interventions: BEHAVIORAL: Psychopathy.comp and training in virtual reality (VR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Extension for the Phase 2 Study in Early Symptomatic Amyotrophic Lateral Sclerosis Patients on Stable Background Therapy to Assess Bioenergetic Catalysis With CNM-Au8 to Slow Disease Progression in ALS
Status: ACTIVE_NOT_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: CNMAu8
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone Infusion to the Adventitia to Enhance Clinical Efficacy After Femoropopliteal Revascularization
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: PROCEDURE: Administration of dexamethasone to SFA/popliteal adventitia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Supplement Containing Various Probiotics and Fermentation Products on Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Mixture of various probiotics and fermentation products|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of CDI-31244: A Novel NNI in HV and HCV Infected Subjects
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: CDI-31244|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Self-Testing Through Rapid Network Distribution
Status: COMPLETED
Conditions: Covid19
Interventions: BEHAVIORAL: COVID-19 self-test|BEHAVIORAL: COVID-19 test referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Efficacy of HIFU Treatment on Rectal Endometriosis Symptoms.
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometriosis
Interventions: DEVICE: HIFU treatment in rectal Endometriosis|DEVICE: SHAM HIFU procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Riociguat for Sarcoidosis Associated Pulmonary Hypertension
Status: UNKNOWN
Conditions: Sarcoidosis
Interventions: DRUG: Riociguat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Ketoconazole on the Metabolism of ABT-263 (Navitoclax).
Status: COMPLETED
Conditions: Lymphoma|Chronic Lymphocytic Leukemia|Solid Tumors
Interventions: DRUG: ABT-263|DRUG: Ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutraceutical Supplement With Standardized Botanicals in Males With Thinning Hair
Status: COMPLETED
Conditions: Hair Thinning
Interventions: DIETARY_SUPPLEMENT: Nutrafol® Men Hair Growth Nutraceutical|OTHER: Placebo Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Antibiotics for Prevention of Infection Following Orthognathic Surgery
Status: RECRUITING
Conditions: Orthognathic Surgical Site Infection
Interventions: DRUG: Cefazolin 2 GM Injection|DRUG: Cefazolin Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Using High-Dose Single Fraction Image-Guided Radiotherapy for Metastatic Lesions to Soft Tissue Masses, Lymph Node, or Bone
Status: COMPLETED
Conditions: Metastatic Disease
Interventions: RADIATION: intensity modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RAdium-223 and SABR Versus SABR for Oligometastatic Prostate Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Radium-223|RADIATION: stereotactic ablative radiotherapy (SABR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Operative Analgesic Efficacy Of Ultrasound Guided Pericapsular Nerve Group Block Versus Combined Suprascapular And Axillary (Circumflex) Nerve Block For Patients Undergoing Shoulder Arthroscopy
Status: NOT_YET_RECRUITING
Conditions: Post Operative Pain
Interventions: PROCEDURE: ultrasound guided pericapsular nerve group shoulder block|PROCEDURE: ultrasound guided suprascapular and axillary nerve block|OTHER: general anesthesia without nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Proliposomal Intravesical Paclitaxel for Treatment of Low-Grade, Stage Ta, Non Muscle Invasive Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer Cell Transitional|Non-Muscle Invasive Bladder Cancer|Bladder Cancer|Urinary Bladder|Transitional Cell Carcinoma of the Bladder|Urinary Bladder Neoplasms|Urologic Neoplasms|Urogenital Neoplasms|Urinary Bladder Diseases|Urologic Diseases
Interventions: DRUG: TSD-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-blind, Placebo-controlled Multicenter Study to Assess the Efficacy, Safety and Tolerability of Tegaserod 2 mg Bid vs Placebo in Patients With Chronic Constipation
Status: TERMINATED
Conditions: Constipation|Chronic Disease
Interventions: DRUG: tegaserod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Adding Instrumented Hip Concentric Abductor Strengthening Exercise in Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis|Pain|Physical Disability
Interventions: DEVICE: hip device-assisted concentric abductor strengthening (HDACAS)|DEVICE: knee device-assisted concentric flexor-extensor strengthening (KDACFES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single and Multiple-Ascending Dose Study of CRN00808 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: CRN00808|DRUG: Placebo Oral Solution|DRUG: Midazolam oral solution|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Ranging Study of OTO-201 in AOMT
Status: COMPLETED
Conditions: Acute Otitis Media|AOMT
Interventions: DRUG: 6 mg ciprofloxacin|DRUG: 12 mg ciprofloxacin|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Safety and Immunogenicity of ADU-623
Status: COMPLETED
Conditions: Astrocytic Tumors|Glioblastoma Multiforme|Anaplastic Astrocytoma|Brain Tumor
Interventions: BIOLOGICAL: Cohort 1|BIOLOGICAL: Cohort 2|BIOLOGICAL: Cohort 3|DRUG: Antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Behavioral Intervention to Reduce Sexual and Injection Risks Among Female Sex Workers Who Also Inject Drugs in Mexico
Status: COMPLETED
Conditions: HIV|HIV Infections
Interventions: BEHAVIORAL: Interactive injection and sexual risk intervention|BEHAVIORAL: Interactive Sexual Risk Intervention|BEHAVIORAL: Interactive Injection Risk Intervention|BEHAVIORAL: Lecture-format presentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity of A/H1N1v Vaccines in Healthy Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: MF59 H1N1 vaccine|BIOLOGICAL: Plain H1N1 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase III Study of SY-5007, a RET Inhibitor, in Patients With Locally Advanced or Metastatic RET Fusion-positive NSCLC
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: SY-5007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Depressive and Anxiety Symptoms Among a Sample of Emergency Department Patients Using Artificial Intelligence (AI) Technology
Status: NOT_YET_RECRUITING
Conditions: Artificial Intelligence (AI)
Interventions: DEVICE: Biometrics (or AI Biomaker)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Health and Wellness Lifestyle Program to Support Community-Dwelling Persons With Traumatic Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: Telehealth-Based Health and Wellness Program (POWERS-TBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Relevance of a 3D Multisegment Foot Model in Predicting and Determining the Clinical Outcome After Ankle and Hindfoot Reconstruction Procedures
Status: RECRUITING
Conditions: Ankle and Hindfoot Alterations
Interventions: OTHER: Plantar pressure measurement|OTHER: Gait analysis|PROCEDURE: Ankle and hindfoot reconstruction surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics of Rosuvastatin and Atorvastatin in Pediatric Dyslipidemia Patients
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: Rosuvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Desensitize Allergic Reactions to Treatments for Blood Disorders
Status: COMPLETED
Conditions: Multiple Myeloma|Amyloidosis
Interventions: DRUG: Lenalidomide|DRUG: Pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Mycoprotein Consumption and Nucleotide Content in Metabolic Health
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Animal protein based diet|OTHER: Low-nucleotide mycoprotein based diet|OTHER: High-nucleotide mycoprotein based diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study of Self-gripping Mesh in TAPP Versus Lichtenstein Hernia Repair
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: PROCEDURE: Laparoscopic transabdominal preperitoneal hernia repair.|PROCEDURE: Lichtenstein hernia repair.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amitriptyline in Treating Hypoglycemia
Status: TERMINATED
Conditions: Type1 Diabetes Mellitus|Hypoglycemia Unawareness
Interventions: DRUG: Amitriptyline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cost-effectiveness Evaluation of Two 10% Urea Creams in Patients With Diabetic Foot Syndrome
Status: COMPLETED
Conditions: Diabetic Foot
Interventions: OTHER: Participants were given the 10% urea cream purchased in pharmacy or supermarket as appropriate after randomisation and their foot skin quality was assessed by validated questionnaire.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prospective Validation of Circulating Tumor Cells & Circulating Endothelial Cells as Biomarkers in Renal Cancer
Status: COMPLETED
Conditions: Clear Cell Renal Cancer|Circulating Tumor Cells|Circulating Endothelial Cells|Prognostic Biomarkers|Predictive Biomarkers
Interventions: OTHER: None- observational study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Osimertinib to Suppress the Progression of Remaining GGN for EGFR Mutation-positive Stage IB-IIIA Lung Adenocarcinoma
Status: RECRUITING
Conditions: Lung Adenocarcinoma
Interventions: DRUG: Osimertinib 80Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ixazomib, Mitoxantrone Hydrochloride, Etoposide, and Intermediate-Dose Cytarabine in Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Recurrent Adult Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: ixazomib|DRUG: mitoxantrone hydrochloride|DRUG: etoposide|DRUG: cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational of Adjuvant Treatment of Breast Cancer With Liposomal Doxorubicin Regimen
Status: RECRUITING
Conditions: Breast Cancer|Liposomal Doxorubicin|Efficacy|Safety|Postoperative Adjuvant Treatment
Interventions: DRUG: Liposomal doxorubicin containing regimen
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Revefenacin in Acute Respiratory Insufficiency in COPD
Status: RECRUITING
Conditions: COPD|Acute Respiratory Failure
Interventions: DRUG: Revefenacin Inhalation Solution [Yupelri]|DRUG: Ipratropium Bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Training to Improve Work Outcomes in Severe Mental Illness
Status: COMPLETED
Conditions: Schizophrenia|Bipolar Disorder|Depression
Interventions: BEHAVIORAL: Individual placement and support plus cognitive training (IPS-CT)|BEHAVIORAL: Individual placement and support plus enhanced support (IPS-ES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Natural Killer Cells in Bone Marrow and Blood Samples From Patients With and Without Hematologic Cancer
Status: TERMINATED
Conditions: Leukemia|Multiple Myeloma and Plasma Cell Neoplasm
Interventions: OTHER: biologic sample preservation procedure|OTHER: immunologic technique|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bivalirudin Plus Stenting in Long Lesion to Avoid Periprocedural Myocardial Necrosis Trial
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Bivalirudin|DRUG: Unfractioned Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Anti-PD-1 (Pembrolizumab) Therapy in Metastatic Melanoma (ADAPTeM)
Status: WITHDRAWN
Conditions: Advanced Melanoma
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, PD, PK and Efficacy of ARGX-113 in Patients With Pemphigus
Status: COMPLETED
Conditions: Pemphigus Vulgaris|Pemphigus Foliaceus
Interventions: DRUG: ARGX-113
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional and Anatomical Outcomes of Dexamethasone Intra-vitreal Implant in Patients With Resistant Macular Edema Secondary to Retinal Vein Occlusion After Intravitreal Anti-VEGF Injection
Status: ACTIVE_NOT_RECRUITING
Conditions: Macular Edema|Retinal Vein Occlusion
Interventions: DEVICE: Intravitreal injection of Dexamethasone implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Ramucirumab With Somatostatin Analog Therapy in Patients With Advanced, Progressive Carcinoid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoid Tumors
Interventions: DRUG: Ramucirumab|DRUG: Somatostatin Analog
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Cannabis in Pancreatic Cancer
Status: WITHDRAWN
Conditions: Neoplasms Pancreatic|Cachexia; Cancer|Cannabis|Appetite Loss|Palliative Medicine|Morbidity|Mortality
Interventions: DRUG: THC and CBD Mixture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of MBSR in Natural Environments
Status: COMPLETED
Conditions: Stress-related Problem
Interventions: OTHER: Mindfulness-based stress reduction (MBSR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Meclizine as a Potential Smoking Cessation Treatment
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Meclizine|DRUG: Nicotine Patch|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Therapeutic Effects of Bu Shen Yi Jing Pill on Semen Quality in Sub Fertile Males: a Randomized Controlled Trial
Status: RECRUITING
Conditions: Male Infertility|Infertility|Traditional Chinese Medication (TCM)|Reproductive Issues
Interventions: DRUG: Bu Shen Yi Jing Pill|DRUG: Placebo Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of NNZ-2566 in Patients With Fragile X Syndrome
Status: COMPLETED
Conditions: Fragile X Syndrome
Interventions: DRUG: NNZ-2566|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Linac FRACtionated Radiosurgical THALamotomie in Tremors (FRACTHAL)
Status: NOT_YET_RECRUITING
Conditions: Essential Tremor|Parkinsonian Disorders
Interventions: RADIATION: Radiosurgical thalamotomy on GammaKnife
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Steps Ahead: Optimising Physical Activity and Health in Adults With Cystic Fibrosis
Status: UNKNOWN
Conditions: Cystic Fibrosis
Interventions: OTHER: Fitness tracker with goal setting and text message feedback|OTHER: Fitness Tracker only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Use of Golimumab (Simponi®) in Participants With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis (P06554)
Status: COMPLETED
Conditions: Arthritis, Rheumatoid|Arthritis, Psoriatic|Spondylitis, Ankylosing
Interventions: DRUG: Simponi®|DRUG: Methotrexate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pomalidomide in Hereditary Hemorrhagic Telangiectasia and Transfusion-Dependent Vascular Ectasia: a Phase I Study
Status: COMPLETED
Conditions: Hereditary Hemorrhagic Telangiectasia|Idiopathic Vascular Ectasia
Interventions: DRUG: Pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carboplatin and Paclitaxel With or Without Bevacizumab Compared to Docetaxel, Carboplatin, and Paclitaxel in Treating Patients With Stage II, Stage III, or Stage IV Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity Carcinoma (Cancer)
Status: COMPLETED
Conditions: Brenner Tumor|Fallopian Tube Cancer|Ovarian Carcinosarcoma|Ovarian Clear Cell Cystadenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Mixed Epithelial Carcinoma|Ovarian Mucinous Cystadenocarcinoma|Ovarian Serous Cystadenocarcinoma|Ovarian Undifferentiated Adenocarcinoma|Primary Peritoneal Cavity Cancer|Stage II Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer
Interventions: DRUG: carboplatin|DRUG: paclitaxel|DRUG: docetaxel|BIOLOGICAL: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of MLN0264 in Adult Patients With Advanced Gastrointestinal Malignancies Expressing Guanylyl Cyclase C
Status: COMPLETED
Conditions: Advanced Gastrointestinal Malignancies
Interventions: DRUG: MLN0264
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Gemcitabine, Cisplatin, and Pembrolizumab in Potentially Resectable Biliary Tract Cancers
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage 2
Status: RECRUITING
Conditions: Cerebrovascular Disorders|Brain Lesion|Degenerative Disease|Developmental Disability
Interventions: BEHAVIORAL: Neuropsychological testing|OTHER: Brain Imaging|OTHER: Galvanic Vestibular Stimulation (GVS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase I Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Oral Dose Escalation of GS1-144 Tablets and the Effects of Food on the Pharmacokinetics of GS1-144 in a Chinese Population
Status: RECRUITING
Conditions: Vasomotor System; Labile|Healthy Volunteer
Interventions: DRUG: GS1-144 tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Multiple Oral Dosing to Evaluate the Safety and the Pharmacokinetic Drug-drug Interaction of Telmisartan/Amlodipine and Rosuvastatin in Healthy Male Volunteers
Status: COMPLETED
Conditions: Hypertension and Dyslipidemia
Interventions: DRUG: Telmisartan|DRUG: Amlodipine|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myocet ® - Carboplatine in Ovarian Cancer in Relapse, Sensitive to the Platinum
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: carboplatin and liposomal doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer Patients
Status: COMPLETED
Conditions: Cancer of Cervix
Interventions: DRUG: gemcitabine|DRUG: cisplatin|RADIATION: chemoradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of the D1 Dopamine Receptor Antagonist Ecopipam in Patients With Lesch-Nyhan Disease
Status: COMPLETED
Conditions: Lesch-Nyhan Disease
Interventions: DRUG: Ecopipam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Diagnosis and Incidence of Critical Illness Polyneuromyopathy in Medical and Neurosurgical ICU Patients
Status: COMPLETED
Conditions: Critical Illness
Interventions: OTHER: Muscle Ultrasound|OTHER: Nerve Conduction Study|OTHER: Electromyography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Study of CD38\CS1 Chimeric Antigen Receptor T Cells in the Treatment of Refractory/Recurrent Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: ORR,OS,PFS
Interventions: BIOLOGICAL: CD38/CS1 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DOSAGE Study: Upfront Dose-Reduced Chemotherapy in Older Patients With Metastatic Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Older Patients|Colorectal Cancer|Metastatic Cancer|Candidates for Palliative Chemotherapy
Interventions: DRUG: Doublet Chemotherapy, Standard Dose (100%)|DRUG: Doublet Chemotherapy, Dose-reduced (75%)|DRUG: Monotherapy, Standard Dose (100%)|DRUG: Monotherapy, Dose-reduced (75%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exosurf Neonatal and Survanta for Treatment of Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Infant, Newborn|Infant, Low Birth Weight|Infant, Small for Gestational Age|Infant, Premature|Bronchopulmonary Dysplasia
Interventions: DRUG: Exosurf|DRUG: Survanta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety of Etanercept in Rheumatoid Arthritis, Ankylosing Spondylitis and Psoriatic Arthritis
Status: TERMINATED
Conditions: Ankylosing Spondylitis|Arthritis, Psoriatic|Arthritis, Rheumatoid|Spondylitis, Ankylosing
Interventions: OTHER: There is no Intervention. The study is observational.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics of a Fixed Dose Combination of Canagliflozin/Metformin Coadministered With Food
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: CANA/MET XR FDC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CLOSE Versus High Density Mapping Guided Catheter Ablation of Paroxysmal Atrial Fibrillation
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Vein Isolation
Interventions: PROCEDURE: Modified CLOSE protocol|PROCEDURE: High density mapping guided pulmonary vein isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Various Serving Sizes of Lentils on Blood Glucose and Insulin
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: 1/4 cup- Small red lentil|OTHER: 1/4 cup- Small green lentil|OTHER: 1/4 cup- corn|OTHER: 1/4 cup- macaroni|OTHER: 1/4 cup- white potato|OTHER: 1/4 cup- white rice|OTHER: 1/2 cup- small red lentil|OTHER: 1/2 cup- small green lentil|OTHER: 1/2 cup- corn|OTHER: 1/2 cup- macaroni|OTHER: 1/2 cup- white potato|OTHER: 1/2 cup- white rice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER