pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Pioglitazone in Patients With Amyotrophic Lateral Sclerosis
Status: TERMINATED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: pioglitazone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brief Alcohol Intervention and mHealth Booster for Suicidal Adolescents
Status: COMPLETED
Conditions: Alcohol Drinking|Suicide, Attempted|Adolescent Behavior
Interventions: BEHAVIORAL: iASIST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Inspiratory Muscle Strength Training in Total Joint Surgery
Status: RECRUITING
Conditions: Arthropathy of Knee|Arthropathy of Hip|Lower Extremity Fracture|Orthopedic Disorder
Interventions: BEHAVIORAL: Daily Inspiratory Muscle Training (dIMT)|BEHAVIORAL: Acute Inspiratory Muscle Training (aIMT)|OTHER: Standard of Care (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Glycemic Response Elicited by Beta-glucans of Different Physical Properties and Form
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: oat beta-glucan|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase II Clinical Study of Pyrotinib in First-line Treatment of Primary HER2-amplified/Mutated Advanced Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Pyrotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peripheral Immunological Effects of High-dose Vitamin D Treatment in Healthy Subjects
Status: COMPLETED
Conditions: Vitamin d Deficiency
Interventions: DRUG: Vitamin D|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluating Omission of Granulocyte Colony-stimulating Factors in Breast Cancer Patients Receiving Paclitaxel Portion of Dose-dense Adriamycin-cyclophosphamide and Paclitaxel Chemotherapy
Status: RECRUITING
Conditions: Early-stage Breast Cancer
Interventions: DRUG: Granulocyte Colony-Stimulating Factor (G-CSF)|DRUG: Omission of Granulocyte Colony-Stimulating Factor (G-CSF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Low-dose Ketamine Infusion for Patients With Obstructive Sleep Apnea
Status: TERMINATED
Conditions: Sleep Apnea|Obstructive Sleep Apnea|Postoperative Complications
Interventions: DRUG: Ketamine|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Testing Ivonescimab Versus FOLFOX in Advanced Biliary Tract Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Biliary Tract Cancer
Interventions: DRUG: Ivonescimab|DRUG: FOLFOX regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Saxagliptin and Atherosclerosis
Status: COMPLETED
Conditions: Coronary Artery Disease|Diabetes Mellitus Type 2
Interventions: DRUG: Saxagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Properties of Nevirapine Extended Release Tablets When Administered Orally in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Nevirapine, low dose|DRUG: Nevirapine, high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kegel and Abdominal Exercises on Urinary Incontinence Severity, Quality of Life, and Sleep Quality in Menopausal Women
Status: COMPLETED
Conditions: Urinary Incontinence|Postmenopausal Symptoms|Sleep Quality
Interventions: BEHAVIORAL: Experimental Group: Kegel exercises and abdominal exercises|BEHAVIORAL: Control Group: Kegel exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectivity of Mesenchymal Stem Cell on Vertebral Bone Defect Due to Mycobaterium Tuberculosis Infection
Status: UNKNOWN
Conditions: Spinal Tuberculosis|Mesenchymal Stem Cell
Interventions: COMBINATION_PRODUCT: Mesenchymal Stem cell + Nacl 0.9%|COMBINATION_PRODUCT: NaCl 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of V-BEAM Conditioning Regimen Prior to Second Autologous Stem Cell Transplantation
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: Carmustine|DRUG: Etoposide|DRUG: Cytarabine|DRUG: Melphalan|PROCEDURE: Stem cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Cold Biopsy Forceps vs Cold Snare for Diminutive Colorectal Polyp Removal
Status: COMPLETED
Conditions: Colorectal Polyps
Interventions: PROCEDURE: Polypectomy of diminutive colorectal polyps will be performed by CBF|PROCEDURE: Polypectomy of diminutive colorectal polyps will be performed by CSP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acalabrutinib in Combination With Anti-CD20 and Venetoclax in Relapsed/Refractory or Untreated CLL/SLL/PLL
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|Prolymphocytic Leukemia
Interventions: DRUG: acalabrutinib|DRUG: Obinutuzumab|DRUG: Venetoclax|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Clinical Results of 3 Different Femoral Fixation in ACL Reconstruction
Status: COMPLETED
Conditions: ACL Injury|Anterior Cruciate Ligament Rupture
Interventions: PROCEDURE: Arthroscopic ACL reconstruction with retensioned hamstring autograft|PROCEDURE: Arthroscopic ACL reconstruction with retensioned and knotted hamstring autograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: We Are Here Now: a Multi-level, Multicomponent Sexual and Reproductive Health Intervention for American Indian Youth
Status: UNKNOWN
Conditions: Reproductive Behavior|Sexual Behavior
Interventions: BEHAVIORAL: We are here now: a multi-level, multi-component sexual and reproductive health intervention for American Indian youth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Depression Interventions After Acute Coronary Syndrome
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Depression
Interventions: BEHAVIORAL: Problem Solving Therapy|DRUG: Sertraline, citalopram, or bupropion|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Ofatumumab Compared to Teriflunomide in Patients With Relapsing Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: Ofatumumab subcutaneous injection|DRUG: Teriflunomide-matching placebo capsules|DRUG: Teriflunomide capsule|DRUG: Matching placebo of ofatumumab subcutaneous injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of DS-7080a for the Treatment of Macular Degeneration
Status: COMPLETED
Conditions: Neovascular Age-Related Macular Degeneration|Diabetic Macular Edema
Interventions: DRUG: DS-7080a|DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determining Highest Dose Administration of TC-5214 and Evaluating Effect on the Electrical Activity in the Heart
Status: TERMINATED
Conditions: Healthy Male
Interventions: DRUG: TC-5214|OTHER: Placebo comparator|DRUG: Moxifloxacin|OTHER: Moxifloxacin placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Roux-en-Y Gastric Bypass (RYGB) Versus Omega-Loop Gastric Bypass (OLGB) Safety and Efficacy Short-term Study
Status: UNKNOWN
Conditions: Obesity, Severe|Diabetes Mellitus, Type 2
Interventions: PROCEDURE: Roux-en-Y Gastric Bypass|PROCEDURE: Omega-Loop Gastric Bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exoskeleton Training for Spinal Cord Injury Neuropathic Pain (ExSCIP)
Status: NOT_YET_RECRUITING
Conditions: Traumatic Spinal Cord Injury
Interventions: DEVICE: Ekoskeleton (Intervention)|OTHER: Relaxation (Comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Shock Waves on Dental Parameters
Status: COMPLETED
Conditions: Tooth Stability|Blood Flow
Interventions: DEVICE: Extracorporeal shockwave therapy|DEVICE: No extracorporeal shockwave
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Therapy of Andrographolid Sulfonatein Community Acquired Pneumonia
Status: UNKNOWN
Conditions: Community Acquired Pneumonia
Interventions: DRUG: Andrographolid Sulfonate Injection (AS Injection)|DRUG: Cephalosporin|DRUG: Azithromycin, Minocycline or Doxycycline|DRUG: Amoxicillin-clavulantic acid|DRUG: Fluoroquinolones|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessing Improvement in Cognitive Deficit in CRS in Patients Treated With Medical Vs Surgical Management
Status: UNKNOWN
Conditions: Chronic Sinusitis
Interventions: PROCEDURE: Private system endoscopic sinus surgery|PROCEDURE: Public system endoscopic sinus surgery|DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Left Ventricular Assist Device (LVAD) Off or On Pump Implantation Study
Status: TERMINATED
Conditions: Heart Failure|LVAD
Interventions: DEVICE: Off-Pump|DEVICE: On-Pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Belotecan Versus Topotecan for Recurrent Ovarian Cancer: A Randomized, Open-label, Parallel-group Phase IIb Trial
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer
Interventions: DRUG: Topotecan|DRUG: Belotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Chitodex Gel in Tympanoplasty Surgery
Status: RECRUITING
Conditions: Tympanic Membrane Perforation|Tympanic Membrane Inflammation|Surgery|Otitis Media
Interventions: DEVICE: Gelfoam|DEVICE: Chitodex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Topical 5-ALA-PDT With Blu-U Therapy Versus Topical 5-ALA With Pulse Dye Laser In Treating Recalcitrant Acne Vulgaris
Status: WITHDRAWN
Conditions: Acne Vulgaris
Interventions: DRUG: 5-ALA with Blu-U Light|DRUG: 5-ALA with Candela V-beam Pulse Dye Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Cord Blood Cell Therapy for Neonatal Encephalopathy
Status: COMPLETED
Conditions: Neonatal Encephalopathy|Hypoxic-ischemic Encephalopathy
Interventions: OTHER: Autologous umbilical cord blood cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Acceptability and Preliminary Effectiveness of Carraguard™ (PC-515) in Preventing HIV/STI Transmission
Status: COMPLETED
Conditions: HIV Infections|Chlamydia Trachomatis|Neisseria Gonorrhoeae|Trichomonas Vaginitis|Syphilis
Interventions: DRUG: Carraguard (PC-515)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Robotically Assisted Treadmill Training in Spinal Cord Injury (SCI)
Status: COMPLETED
Conditions: Paraplegia|Quadriplegia|Spinal Cord Injury|Tetraplegia
Interventions: DEVICE: Lokomat Training|OTHER: Home stretching then Lokomat training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Customized Treatment According to BRCA1 Assessment in Patients With Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Advanced Gastric Cancer
Interventions: DRUG: FLOT Regimen|DRUG: FLO Regimen or FLOT Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Introducer Curving Technique for Tilt of Transfemoral Günther Tulip Inferior Vena Cava Filter
Status: COMPLETED
Conditions: Deep Venous Thrombosis
Interventions: DEVICE: curving introducer Günther Tulip Filter|DEVICE: straight introducer Günther Tulip Filter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase III Study of TACI-antibody Fusion Protein Injection (RC18) in Subjects With Neuromyelitis Optica Spectrum Disorders
Status: RECRUITING
Conditions: Neuromyelitis Optica Spectrum Disorders
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: RC18 160 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An 8-week Dose Ranging Study of CHF 718 pMDI in Asthmatic Subjects
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: CHF 718 pMDI|DRUG: Placebo pMDI|DRUG: Beclomethasone Dipropionate (BDP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pharmacokinetic Study of Testosterone Enanthate
Status: COMPLETED
Conditions: Hypogonadism
Interventions: DRUG: QuickShot™ - 50 mg Treatment B|DRUG: QuickShot™ - 100 mg Treatment A|DRUG: Delatestryl 200 mg IM Treatment C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studies in Patients With Multiple Myeloma and Renal Failure Due to Myeloma Cast Nephropathy
Status: COMPLETED
Conditions: Chronic Renal Failure With Uremic Nephropathy
Interventions: DRUG: Cyclophosphamide + Bortezomib + Dexamethasone regimen|DRUG: Bortezomib +Dexamethasone regimen|DEVICE: HCO group|DEVICE: conventional high-flux dialyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Using a Storybook, to Explain Leukemia to Children Versus the Standard Child Life Intervention, on Parental Stress.
Status: RECRUITING
Conditions: Leukemia
Interventions: BEHAVIORAL: "Who is Luke Eemia?" Storybook
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Digestive Symptoms in Systemic Sclerosis Systemic Sclerosis
Status: RECRUITING
Conditions: Systemic Sclerosis
Interventions: DEVICE: Auricular vagus nerve stimulation|DEVICE: Sham Auricular vagus nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuropeptides and Social Behavior
Status: COMPLETED
Conditions: Social Psychology
Interventions: DRUG: Intranasal oxytocin|DRUG: Intranasal vasopressin|DRUG: Intranasal placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility Assessment of a Patients Follow-up Visit Receiving Trastuzumab Subcutaneous by Advanced Practice Nurse
Status: UNKNOWN
Conditions: Breast Neoplasms
Interventions: OTHER: Advanced Practice Nurse consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy Study of ALZT-OP1 in Subjects With Evidence of Early Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: ALZT-OP1a|DRUG: ALZT-OP1b|OTHER: Placebo ALZT-OP1a|OTHER: Placebo ALZT-OP1b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post- Myocardial Infarction Arterial Wall Improvement by Low-dose Fluvastatin and Valsartan
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: low-dose combination of fluvastatin (10 mg) and valsartan (20 mg) (low-flu/val)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Non-pharmacological Intervention for Preclinical Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease|Functional Food|Subjective Cognitive Decline|Intervention|Neuroimaging
Interventions: DIETARY_SUPPLEMENT: Mixed functional foods supplementation|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pembrolizumab in Combination With Paclitaxel in the Hormone Receptor-positive Metastatic Breast Cancer With High Tumor Mutational Burden Selected by Whole Exome Sequencing: Korean Cancer Study Group Trial (KCSG BR20-16)
Status: UNKNOWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Human Umbilical Cord Mesenchymal Stem Cells (IxCell hUC-MSC-S) in the Treatment of Ischemic Stroke
Status: NOT_YET_RECRUITING
Conditions: Ischemic Stroke
Interventions: BIOLOGICAL: MSC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Transdermal Vitamin D3 Delivery System, D3forME
Status: WITHDRAWN
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Transdermal D Patch|DIETARY_SUPPLEMENT: Oral vitamin D3|DIETARY_SUPPLEMENT: Placebo patch|DIETARY_SUPPLEMENT: Oral placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn More About the Safety of the Drug Vericiguat in Japanese People With Chronic Heart Failure Who Will be Receiving Vericiguat Under Real-world Conditions
Status: RECRUITING
Conditions: Chronic Heart Failure
Interventions: DRUG: Vericiguat (Verquvo, BAY1021189)|DRUG: Standard of care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immediate Effects of Whole-Body Vibration on Neuromuscular Performance and Postural Control in Elderly
Status: COMPLETED
Conditions: Neuromuscular Performance and Balance
Interventions: OTHER: WBV exercise group|OTHER: Sham WBV exercise group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Evorpacept (ALX148) in Patients With Advanced Solid Tumors and Lymphoma (ASPEN-01)
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Cancer|Solid Tumor|Advanced Cancer|NonHodgkin Lymphoma
Interventions: DRUG: Evorpacept (ALX148)|DRUG: Pembrolizumab|DRUG: Trastuzumab|DRUG: Rituximab|DRUG: Ramucirumab + Paclitaxel|DRUG: 5-FU + Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Root Canal Preparation by TF and M-Pro on Post-Operative Pain After Single Visit Endodontic Treatment
Status: COMPLETED
Conditions: Acute Pulpitis
Interventions: DEVICE: Twisted file|DEVICE: Mpro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Effects of Mirror Therapy Combined With Neuromuscular Electrical Stimulation or Binaural Beats Stimulation on Cortical Excitability, Heart Rate Variability and Lower Limb Motor Function in Patients With Stroke
Status: RECRUITING
Conditions: Stroke|Healthy Adults
Interventions: OTHER: Mirror Therapy|OTHER: Mirror Therapy + Electrical Stimulation|OTHER: Mirror Therapy + Binaural Beat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TMC435-TiDP16-C119 - A Study Comparing 2 New Capsule Formulations of TMC435 to an Established Capsule Formulation and Evaluating the Respective Blood Levels of TMC435 Following Single Dose Administration
Status: COMPLETED
Conditions: Hepatitis C Virus
Interventions: DRUG: TMC435 (G006)|DRUG: TMC435 (F021)|DRUG: TMC435 (G007)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Safety Program for the Use of Zalcitabine (Dideoxycytidine; ddC) in Pediatric Patients With Symptomatic HIV Infection Who Have Failed or Are Intolerant to AZT Monotherapy, or Who Have Completed Other ddC Protocols, or Are Ineligible for Other Ongoing Clinical Studies
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zalcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Energy HoLEP on IPSS
Status: UNKNOWN
Conditions: Prostate Hyperplasia|Prostatic Hypertrophy|Surgery|Bladder Outlet Obstruction|Quality of Life|Complication of Surgical Procedure
Interventions: DEVICE: Holmium laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Observational Study of Multiple Sclerosis (MS) Patients Starting or Restarting Baseline Treatment With Interferon Beta 1a After the Use of Escalation Treatment With Mitoxantrone
Status: COMPLETED
Conditions: Relapsing-Remitting Multiple Sclerosis
Interventions: DRUG: Interferon beta 1a
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fasting Study of Lorazepam Tablets 2 mg and Ativan Tablets 2 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lorazepam Tablets 2 mg|DRUG: Ativan Tablets 2 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety, Tolerability and Pharmacokinetics of BI 44370 TA Oral Drinking Solution in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 44370 TA solution|DRUG: BI 44370 TA tablet|DRUG: Placebo solution|DRUG: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of NexoBrid in Children With Thermal Burns Compared the Standard of Care
Status: UNKNOWN
Conditions: Thermal Burns
Interventions: DRUG: NexoBrid|PROCEDURE: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Effects of AMG 557 in Adults With Psoriasis
Status: TERMINATED
Conditions: Psoriasis
Interventions: DRUG: AMG 557 or PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Propranolol Hydrochloride in Combination With Sintilimab and Platinum-based Chemotherapy for Treatment of Advanced Non-small Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Non Small Cell Lung Cancer|Propranolol
Interventions: DRUG: Propranolol hydrochloride|DRUG: Sintilimab|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arsenic Trioxide in Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Arsenic Trioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-blind, Randomized, Parallel, Placebo-controlled Clinical Study to Evaluate the Viral Load of SARS-CoV-2 (COVID-19) in the Oral Cavity of SARS-CoV-2 Positive Subjects After the Use of a Mouthwash Containing Cetylpyridinium Chloride 0,07%.
Status: COMPLETED
Conditions: SARS-CoV-2 Infection
Interventions: OTHER: 0.07% cetylpyridinium chloride (CPC) in mouthwash|OTHER: Distilled water with the same colorant as the experimental product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the Liver
Status: COMPLETED
Conditions: Echinococcosis, Hepatic|Hydatid Cyst
Interventions: PROCEDURE: laparoscopic surgery|PROCEDURE: open surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Performance of Automatic Fusion for Radiofrequency Ablation of Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DEVICE: Automatic Imaging fusion of ultrasonography and MRI|DEVICE: Manual Imaging fusion of ultrasonography and MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biofeedback vs Laryngeal Control Therapy in Management of Paradoxical Vocal Fold Motion
Status: ACTIVE_NOT_RECRUITING
Conditions: Paradoxical Vocal Fold Motion|Vocal Cord Dysfunction
Interventions: BEHAVIORAL: Biofeedback|BEHAVIORAL: Laryngeal control therapy (LCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Efficacy of 4 Oral Analgesics
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Oxycodone/acetaminophen|DRUG: Hydrocodone/acetaminophen|DRUG: Codeine/acetaminophen|DRUG: Ibuprofen/acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Exercise in End-stage Renal Disease Patients Undergoing Hemodialysis
Status: COMPLETED
Conditions: End Stage Renal Failure on Dialysis
Interventions: OTHER: Progressive resistance training|OTHER: Aerobic training|OTHER: Placebo training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Verinurad and Allopurinol in Combination With Cyclosporine and Rifampicin in Healthy Volunteers
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Verinurad|DRUG: Allopurinol|DRUG: Cyclosporine|DRUG: Rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Heparin Reversal With Two Different Protamine Ratios After Cardiopulmonary By-pass.
Status: COMPLETED
Conditions: Cardiac Surgery|CAD|Valve Heart Disease|Coagulation Disorder
Interventions: DRUG: Protamin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Modification for the Treatment of Symptomatic Atrial Fibrillation (LIFE-AF)
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: BEHAVIORAL: Multicomponent Risk Factor Modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of the Effectiveness and Safety of Software Assisting Diagnose the Intestinal Polyp Digestive Endoscopy by Analysis of Colonoscopy Medical Images From Electronic Digestive Endoscopy Equipment
Status: COMPLETED
Conditions: Artificial Intelligence|Enteroscope|Intestinal Polyposis, Adenomatous
Interventions: DEVICE: DeFrame
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Antibody Persistence for GlaxoSmithKline (GSK) Biologicals' HPV-16/18 L1 VLP AS04 Vaccine (GSK-580299) Administered in Healthy Adults and Adolescents, 6.5 Years After First Vaccination in the Primary Study
Status: WITHDRAWN
Conditions: Infections, Papillomavirus
Interventions: PROCEDURE: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Anastrazole and Clomiphene to Evaluate Hypogonadal Symptoms and Erectile Function
Status: COMPLETED
Conditions: Hypogonadism, Male
Interventions: DRUG: Anastrozole 1mg|DRUG: Clomiphene Citrate 25mg|DRUG: Placebo - Cap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of a Diary for Allogenic Hematopoietic Stem Cell Transplantation Patients and Families
Status: COMPLETED
Conditions: Hematopoietic/Lymphoid Cancer|Psychological Disorder
Interventions: BEHAVIORAL: quality of life questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: "Prime Boost" Vaccination Strategy Combining Conjugated Anti- Pneumococcal Vaccine (s0) and Polysaccharide Anti- Pneumococcal Vaccine (s4) Compared to Polysaccharide Anti- Pneumococcal Vaccine Alone (s4) In Patients With Common Variable Immunodeficiency
Status: TERMINATED
Conditions: Common Variable Immunodeficiency
Interventions: BIOLOGICAL: PPS|BIOLOGICAL: PnCJ PPS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Perifosine Plus Capecitabine Versus Placebo Plus Capecitabine in Patients With Refractory Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Capecitabine|DRUG: Perifosine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Project HEALS (Helping and Empowering pAtients for Living a Life Smoke-free
Status: COMPLETED
Conditions: Smoking|Tobacco Use|Lung Cancer
Interventions: DRUG: Nicotine patch and lozenges|BEHAVIORAL: Telephone counseling sessions|BEHAVIORAL: Access to a web-based video|BEHAVIORAL: Florida Tobacco Quitline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity Study of Two Doses of Novartis Meningococcal Serogroup B Recombinant Vaccine in Adolescents Aged 11-17 Years.
Status: COMPLETED
Conditions: Meningococcal Disease
Interventions: BIOLOGICAL: Meningococcal B Recombinant vaccine rMenB+OMV NZ|BIOLOGICAL: Placebo|BIOLOGICAL: Meningococcal ACWY-CRM conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study of SHP674 (Pegaspargase) in Participants With Newly Diagnosed, Untreated Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: SHP674
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on The Potential of Aleglitazar to Reduce Cardiovascular Risk in Patients With Stable Cardiovascular Disease and Glucose Abnormalities
Status: COMPLETED
Conditions: Cardiovascular Disease, Diabetes Mellitus Type 2
Interventions: DRUG: Placebo|DRUG: aleglitazar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ultra-Rush Sublingual Immunotherapy in Children With Asthma Allergic to Grass Pollen
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Staloral 300|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Single Doses of YF476 on Stomach Acidity
Status: COMPLETED
Conditions: Hypergastrinaemia
Interventions: DRUG: YF476|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Effectiveness and Safety of Physician Versus Patient-led of Insulin Glargine Initiation and Titration in Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Patients Taking Olanzapine and Patients Taking Aripiprazole on Learning of Vocational Skills
Status: COMPLETED
Conditions: Schizophenia Disorder|Schizoaffective Disorder
Interventions: DRUG: aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Combined Effects of Kegel Exercises and 4-7-8 Breathing Technique in Primary Dysmenorrhea
Status: NOT_YET_RECRUITING
Conditions: Primary Dysmenorrhea
Interventions: OTHER: KegelExercise|OTHER: 4-7-8 breathing technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective, Randomized, Non-inferiority Investigation to Compare Effects of Mepitel® One and UrgoTul® Dressings in Acute Wound Management (Only)"
Status: COMPLETED
Conditions: Pain
Interventions: DEVICE: Mepitel One|DEVICE: UrgoTul
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Ketamine and Morphine in the Treatment of Acute Fracture Pain
Status: TERMINATED
Conditions: Acute Pain|Fractures
Interventions: DRUG: ketamine|DRUG: morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pirfenidone as a Radiosensitizer in the Treatment of Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma|Radiotherapy|Radiosensitizer|Pirfenidone
Interventions: DRUG: Pirfenidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Placebo-Controlled Study of the Efficacy and Safety of BG00012 in Pediatric Subjects With Relapsing-Remitting Multiple Sclerosis (RRMS)
Status: WITHDRAWN
Conditions: Relapsing-Remitting Multiple Sclerosis|Relapsing Forms of Multiple Sclerosis
Interventions: DRUG: dimethyl fumarate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test How Effective and Safe Different Doses of BI 655130 Are in Patients With a Moderate to Severe Form of the Skin Disease Palmoplantar Pustulosis
Status: COMPLETED
Conditions: Palmoplantar Pustulosis (PPP)
Interventions: DRUG: Spesolimab|DRUG: Placebo|DRUG: Spesolimab|DRUG: Spesolimab|DRUG: Spesolimab|DRUG: Spesolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Epi-no Device on Pelvic Floor Dysfunctions
Status: COMPLETED
Conditions: Pelvic Floor Disorders|Urinary Incontinence|Dyspareunia|Lacerations Perineal
Interventions: DEVICE: Epi-No®|DIAGNOSTIC_TEST: Evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Efficacy and Safety of Topiramate in Epilepsy Patients With Primary Generalized Tonic-clonic Seizures
Status: COMPLETED
Conditions: Epilepsy|Seizures
Interventions: DRUG: topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Mother-infant Bonding During COVID-19
Status: RECRUITING
Conditions: Child Development|Mother-Infant Interaction|Relation, Parent-Child
Interventions: BEHAVIORAL: Emotional Exchange (EE)|OTHER: Newborn Care (NC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of TJ033721 in Subjects With Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor|Advanced Cancer|Metastatic Cancer|Gastric Cancer|Gastroesophageal Junction Carcinoma|Esophageal Adenocarcinoma
Interventions: DRUG: TJ033721|DRUG: TJ033721, nivolumab, chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Safety and Immunogenicity of rVSV∆G-LASV-GPC Vaccine in Adults in Good General Heath
Status: ACTIVE_NOT_RECRUITING
Conditions: Lassa Fever|Lassa Virus Infection
Interventions: DRUG: rVSV∆G-LASV-GPC|DRUG: rVSV∆G-LASV-GPC|DRUG: rVSV∆G-LASV-GPC|DRUG: rVSV∆G-LASV-GPC|OTHER: Placebo/Diluent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Continuous Glucose Monitoring During Diets That Differ in Glycemic Load
Status: COMPLETED
Conditions: Glucose Metabolism Disorders
Interventions: DIETARY_SUPPLEMENT: Low glycemic load|DIETARY_SUPPLEMENT: High glycemic load
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Open-Label Study of XOMA 358 in Patients With Hypoglycemia After Gastric Bypass Surgery
Status: COMPLETED
Conditions: Hypoglycemia
Interventions: DRUG: XOMA 358 single dose level A|DRUG: XOMA 358 single dose level B|DRUG: XOMA 358 single dose level C|DRUG: XOMA 358 multiple dose level 1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Auricular VNS Following Subarachnoid Hemorrhage
Status: RECRUITING
Conditions: Subarachnoid Hemorrhage
Interventions: DEVICE: Auricular Vagus Nerve Stimulation|DEVICE: Sham Auricular Vagus nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Finlândia Hair Lotion Association on Androgenetic Alopecia
Status: RECRUITING
Conditions: Androgenetic Alopecia
Interventions: DRUG: Finlândia Association + finasteride placebo|DRUG: Minoxidil + finasteride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bivalirudin vs Heparin in ECMO Patients
Status: WITHDRAWN
Conditions: Extracorporeal Membrane Oxygenation Complication
Interventions: DRUG: Heparin Sodium|DRUG: Bivalirudin Injection [Angiomax]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Patients With Chronic Kidney Disease to Assess the Safety of a Single Dose of COR-001
Status: COMPLETED
Conditions: Chronic Kidney Diseases
Interventions: DRUG: COR-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Diagnosis and Treatment of Patients With Autoimmune Cytopenias Including Autoimmune Hemolytic Anemia, Immune Thrombocytopenia, and Chronic Idiopathic/Autoimmune Neutropenia
Status: RECRUITING
Conditions: Autoimmune Hemolytic Anemia|Immune Thrombocytopenia|Chronic Idiopathic Neutropenia|Autoimmune Neutropenia|Myelodysplastic Syndromes|Cold Agglutinin Disease
Interventions: BIOLOGICAL: cytokine essays|BIOLOGICAL: NGS|BIOLOGICAL: Fecal microbiome|DRUG: Erythropoietin|DRUG: Luspatercept|DRUG: Thrombopoietin Receptor Agonist|DRUG: G-CSF
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Focal Prostate Ablation With Androgen Deprivation and Novel Hormonal Therapy for Intermediate Risk Prostate Cancer
Status: SUSPENDED
Conditions: Prostate Cancer
Interventions: DRUG: Apalutamide Oral Product|DRUG: Androgen Deprivation Therapy (ADT)|PROCEDURE: Focal Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of ADC4022 Co-Administered With Budesonide on Pulmonary Inflammation in Subjects With Moderate to Severe COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Theophylline - ADC4022|DRUG: Placebo|DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Beetroot Juice on Locomotor Economy and Capacity in Chronic Stroke
Status: COMPLETED
Conditions: Stroke|CVA
Interventions: DIETARY_SUPPLEMENT: Beetroot Juice supplement|DIETARY_SUPPLEMENT: Placebo supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Outcome of Diabetes Education Among Renal Transplant Recipients With New Onset Diabetes After Transplantation (NODAT)"
Status: COMPLETED
Conditions: New Onset Diabetes After Transplant|Diabetes Mellitus
Interventions: OTHER: group education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Safety and Tolerability of Long-term Administration of Gantenerumab in Participants With Alzheimer's Disease (AD)
Status: TERMINATED
Conditions: Alzheimer Disease
Interventions: DRUG: Gantenerumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cohort Study of German Hematological / Oncological Wards to Assess the Effect of Contact Precautions on Nosocomial Colonization With Vancomycin Resistant Enterococci
Status: UNKNOWN
Conditions: Vancomycin (Glycopeptide) Resistant Enterococcus (VRE)|Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Contribution of MRI in the Evaluation of Apparent Diffusion Coefficient and Prediction of Response to Neoadjuvant Chemotherapy in Breast Cancer
Status: WITHDRAWN
Conditions: Assess the Variation of Apparent Diffusion Coefficient
Interventions: OTHER: MRI (Magnetic resonance imaging)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With a Tumour in the Brain That is Positive for DLL3
Status: RECRUITING
Conditions: Glioma
Interventions: DRUG: BI 764532
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Alternative Implants for the Surgical Treatment of Hip Fractures (The FAITH Study)
Status: COMPLETED
Conditions: Femoral Neck Fractures
Interventions: DEVICE: Open reduction internal fixation (ORIF) with single sliding hip screw|DEVICE: ORIF with multiple cancellous screws
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT