pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Reversal of Cardiomyopathy by Suppression of Frequent Premature Ventricular Complexes
Status: UNKNOWN
Conditions: Heart Diseases|Cardiac Arrhythmias|Ventricular Premature Complexes|Systolic Heart Failure|Cardiomyopathies
Interventions: OTHER: PVC suppression therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of SARS Caused by COVID-19 With Ruxolitinib
Status: COMPLETED
Conditions: COVID-19|Severe Acute Respiratory Syndrome Coronavirus 2
Interventions: DRUG: Ruxolitinib Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety, Efficacy, and Pharmacokinetics of SKY0402 in Subjects Undergoing Inguinal Hernia Repair
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: DRUG: SKY0402|DRUG: Bupivacaine HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ-73763989 + Nucleos(t)Ide Analog in Participants Co-Infected With Hepatitis B and Hepatitis D Virus
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatitis D, Chronic
Interventions: DRUG: JNJ-73763989|DRUG: Placebo|DRUG: Entecavir (ETV) monohydrate|DRUG: Tenofovir disoproxil|DRUG: Tenofovir alafenamide (TAF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer
Status: RECRUITING
Conditions: Prostate Cancer|Oligometastasis|Oligorecurrence|Recurrent Prostate Cancer|Metastatic Prostate Cancer|De Novo Prostate Cancer
Interventions: PROCEDURE: PET-directed Local Therapy using Surgery|RADIATION: PET-directed Local Therapy using Radiation|OTHER: Salvage Local Therapy for locally recurrent disease|DRUG: Goserelin, Histrelin, Leuprolide & Triptorelin|DRUG: ADT + Nilutamide, Flutamide, & Bicalutamide|DRUG: Degarelix & Relugolix|DRUG: ADT + Docetaxel +/- prednisone|DRUG: ADT + Abiraterone + Prednisone|DRUG: ADT + Abiraterone + Methylprednisolone|DRUG: ADT + Apalutamide|DRUG: ADT + Enzalutamide|RADIATION: Prostate-directed Radiation for De novo oligometastatic prostate cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interleukin-12 and Interferon Alfa in Treating Patients With Metastatic Kidney Cancer or Malignant Melanoma
Status: COMPLETED
Conditions: Kidney Cancer|Melanoma (Skin)
Interventions: BIOLOGICAL: recombinant interferon alfa|BIOLOGICAL: recombinant interleukin-12
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ET190L1-ARTEMIS™ T Cells in Relapsed, Refractory B Cell Leukemia and Lymphoma
Status: UNKNOWN
Conditions: CD19+ Lymphoma, B-Cell|CD19+ Leukemia, B-Cell
Interventions: BIOLOGICAL: ET190L1-ARTEMIS™ T cells -iv low dose|BIOLOGICAL: ET190L1-ARTEMIS™ T cells -iv middle dose|BIOLOGICAL: ET190L1-ARTEMIS™ T cells - iv high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ceritinib in Mutation and Oncogene Directed Therapy in Thyroid Cancer
Status: WITHDRAWN
Conditions: Metastatic Anaplastic Thyroid Cancer|Locally Advanced Anaplastic, Undifferentiated Thyroid Cancer
Interventions: DRUG: Ceritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Efficacy and Safety Study of Favipiravir for Treatment of Uncomplicated Influenza in Adults
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: favipiravir|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Anti-interleukin 5 (IL5) Therapy on Sputum Cells and Cytokines
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Mepolizumab Injection [Nucala]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COhort for Bardet-Bield Syndrome and Alström Syndrome for Translational Research Monocentric Interventional Study
Status: RECRUITING
Conditions: Bardet-Biedl Syndrome|Alström Syndrome
Interventions: GENETIC: Skin biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ziprasidone Pharmacokinetics Using a Reduced Food Effect Formulation Compared to Pharmacokinetics From Commercial Capsules
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ziprasidone|DRUG: B16 Fasted|DRUG: B16 Fed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Biological Effects of a Bipolar Radiofrequency-based Device Over Shoulder Cartilage
Status: UNKNOWN
Conditions: Glenohumeral Arthritis
Interventions: DEVICE: WEREWOLF COBLATION System|PROCEDURE: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Establish the Role of Premotor and Motor Cortices in tDCS-facilitated Speech Motor Learning
Status: RECRUITING
Conditions: Healthy
Interventions: DEVICE: Anodal speech motor tDCS|DEVICE: Cathodal speech motor tDCS|DEVICE: Anodal IFG tDCS|DEVICE: Cathodal IFG tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Perioperative Chemotherapy Plus Cetuximab Versus Chemotherapy Alone for High Risk Resectable Colorectal Liver Metastasis
Status: COMPLETED
Conditions: Colorectal Cancer Stage IV|Metastasis
Interventions: DRUG: Cetuximab plus FOLFIRI/FOLFOX|DRUG: FOLFIRI/FOLFOX/CapeOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RECO Flow Restoration Device Versus Solitaire FR With the Intention for Thrombectomy Study
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DEVICE: RECO flow restoration device|DEVICE: Solitaire FR flow restoration device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of the Performance of the French Version of the Cerebellar Cognitive-Affective Syndrome Scale (CCASS) as a Screening Test for Cerebellar Cognitive-affective Syndrome: a National Multicenter Study
Status: RECRUITING
Conditions: Cerebellar Cognitive-affective Syndrome
Interventions: DIAGNOSTIC_TEST: Cerebellar Cognitive-Affective Syndrome Scale
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Biological Signatures, Probiotic Among Those With mTBI and PTSD
Status: COMPLETED
Conditions: Mild Traumatic Brain Injury|Post Traumatic Stress Disorder
Interventions: DIETARY_SUPPLEMENT: of Lactobacillus reuteri (L. reuteri; DSM 17938)|OTHER: Sunflower and medium chain triglyceride oils
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of Combined Therapy IVIG-SN 10% and Acetylsalicylic Acid in Kawasaki Disease
Status: COMPLETED
Conditions: Kawasaki Disease
Interventions: DRUG: Immunoglobulin G|DRUG: Acetylsalicylic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Milk Protein and Prebiotics in Combination With Vitamin D on Innate Immunity in Elderly People
Status: COMPLETED
Conditions: Immunosenescence|Inflammation
Interventions: DIETARY_SUPPLEMENT: Milk protein, prebiotics, vitamin D|DIETARY_SUPPLEMENT: Placebo product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and ALK rEarrangements
Status: RECRUITING
Conditions: Lung Cancer|NSCLC|Brain Metastases
Interventions: DRUG: Alectinib|RADIATION: Stereotactic Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Efficacy of DPI-386 Nasal Gel on Ocean-Going Vessels
Status: UNKNOWN
Conditions: Prevention of Nausea Associated With Motion Sickness|Treatment of Nausea Associated With Motion Sickness
Interventions: DRUG: Scopolamine Transdermal Patch [Transderm Scop]|DRUG: Scopolamine|DRUG: Placebo Patch|DRUG: Placebo Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Resveratrol Excipient Paclitaxel Coated Balloon for Coronary Treatment
Status: WITHDRAWN
Conditions: In-stent Coronary Artery Restenosis|Coronary Artery Restenosis|In-stent Restenosis
Interventions: DEVICE: SeQuent Please ReX|DEVICE: Plain old balloon angioplasty (POBA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nucleus Basalis Deep Brain Stimulation for Thinking & Memory Problems in Parkinson's.
Status: COMPLETED
Conditions: Dementia in Parkinson's Disease
Interventions: DEVICE: NBM DBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Genetic Mechanisms in Human Hypertension Renin-angiotensin-aldosterone System (RAAS) Inhibition Study
Status: WITHDRAWN
Conditions: Hypertension
Interventions: DRUG: Lisinopril, Atenolol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial With Riluzole in Spinocerebellar Ataxia Type 2 (ATRIL)
Status: COMPLETED
Conditions: Spinocerebellar Ataxia Type 2
Interventions: DRUG: Riluzole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial to Evaluate the Safety, Tolerability, Efficacy, and Pharmacodynamics for the Treatment of COVID-19.
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: ADX-629|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Serious Pediatric Illness on Parent and Sibling Health
Status: COMPLETED
Conditions: Family Members of: Newborns Extremely Premature|Family Members of: New Pediatric Oncology Patients|Family Members of: Critical Congenital Heart Defect Patients|Family Members of: Children Severe Neurological Impairment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: General Anesthesia Versus Sedation During Intra-arterial Treatment for Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: Etomidate|DRUG: Succinylcholine|DRUG: Propofol|DRUG: Remifentanil|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Potential Interaction Between Ezetimibe and Rosuvastatin in Healthy Subjects With High Cholesterol (P03317)
Status: COMPLETED
Conditions: Hypercholesterolemia|Atherosclerosis
Interventions: DRUG: Ezetimibe + Rosuvastatin|DRUG: Rosuvastatin|DRUG: Placebo|DRUG: Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Avastin for CNV Secondary to Pattern Dystrophy
Status: UNKNOWN
Conditions: Choroidal Neovascularization Secondary to Pattern Dystrophy
Interventions: PROCEDURE: intravitreal triamcinolone injection of avastin (1.25 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Mobile Health for Alcohol Use Disorders in Clinical Practice
Status: COMPLETED
Conditions: Alcohol Drinking|Telemedicine
Interventions: BEHAVIORAL: A-CHESS self-monitored|BEHAVIORAL: A-CHESS peer-supported|BEHAVIORAL: A-CHESS clinically-integrated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Treatment With 2 Different Dosing Schedules of Trabectidin Administered to Patients With Advanced Cancer
Status: COMPLETED
Conditions: Liposarcoma|Leiomyosarcoma
Interventions: DRUG: Yondelis|DRUG: Yondelis|DRUG: Dexamethasone|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Finding Study of AVE1642 in Patients With Advanced or Metastatic Liver Carcinoma
Status: TERMINATED
Conditions: Liver Carcinoma
Interventions: DRUG: AVE1642|DRUG: sorafenib|DRUG: erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Growth Hormone Injection on the IVF/ICSI Outcome of Patients With Poor Ovarian Reserve.
Status: UNKNOWN
Conditions: Poor Ovarian Reserve
Interventions: DRUG: Polyethylene Glycol Recombinant Human Somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Health Promotion Program to Prevent Frailty and Improve Frailty Status Among Pre-frail Elderly: Frailty Intervention Through Nutrition Education and Exercises.
Status: COMPLETED
Conditions: Frail Elderly Syndrome
Interventions: BEHAVIORAL: Frailty Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Dextrose, Corticosteroids and Surgical Release in Carpal Tunnel Syndrome
Status: UNKNOWN
Conditions: Peripheral Nervous System Diseases|Nerve Compression Syndromes|Carpal Tunnel Syndrome
Interventions: DRUG: Corticosteroid vs. Dextrose|PROCEDURE: Corticosteroid or Dextrose vs. Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 177Lu-DOTATOC for the Treatment of Patients With Somatostatin Receptor Positive NETs
Status: WITHDRAWN
Conditions: Neuroendocrine Tumors|Carcinoid Tumor|Pulmonary Carcinoid Tumor|Gastroenteropancreatic Neuroendocrine Tumor|Vipoma|Insulinoma|Gastrinoma
Interventions: DRUG: 177Lu-DOTATOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Smart Health Management Program for Patients With Chronic Illness
Status: COMPLETED
Conditions: Hypertension|Dyslipidemias|Diabetes Mellitus
Interventions: BEHAVIORAL: ICT programs|BEHAVIORAL: A book about chronic disease
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: HDDO-1614 Intervention Trial
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Bazedoxifene 20 mg|DRUG: Cholecalciferol|DRUG: Bazedoxifene 20mg and Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Phase I Study of Pyrimethamine in Patients With GM2 Gangliosidosis
Status: WITHDRAWN
Conditions: G(M2) Ganglioside|Tay-Sachs Disease Ganglioside|Sandhoff Disease Ganglioside
Interventions: DRUG: Pyrimethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Liposomal Bupivacaine Versus Lidocaine for Skin Graft Donor Site Pain
Status: RECRUITING
Conditions: Pain, Postoperative|Burns
Interventions: DRUG: Lidocaine Hydrochloride|DRUG: Liposomal bupivacaine|DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fenestrated Screw Study
Status: TERMINATED
Conditions: Degenerative Spinal Disease|Deformity of Spine
Interventions: DEVICE: CD HORIZON® Fenestrated Screw System with Fenestrated Screw Cement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CLN-978 in Patients With Relapsed or Refractory (R/R) B Cell Non-Hodgkin Lymphoma (B-NHL)
Status: ACTIVE_NOT_RECRUITING
Conditions: NHL|NHL, Relapsed, Adult
Interventions: DRUG: CLN-978
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Motexafin Gadolinium (MGd) for Second Line Treatment of Non-Small-Cell Lung Cancer
Status: COMPLETED
Conditions: Adenocarcinoma|Non-Small-Cell Lung Carcinoma|Lung Neoplasms
Interventions: DRUG: Motexafin Gadolinium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Effects of Nutritional and Exercise Countermeasures
Status: COMPLETED
Conditions: Muscular Atrophy|Muscle Weakness
Interventions: BEHAVIORAL: Resistance Exercise|DIETARY_SUPPLEMENT: diet orange soda|DIETARY_SUPPLEMENT: essential amino acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Individualized Goal-directed Sufentanil Administration Versus Standard Therapy in Patients Undergoing Major Abdominal Surgery
Status: COMPLETED
Conditions: Major Abdominal Surgery
Interventions: DEVICE: Analgesia Nociception Index (ANI)-guided sufentanil administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Safety and Tolerability of BioPB-01 in Healthy Adults
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: OTHER: BioPB-01|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Axillary Lymph Node Dissection Versus no Dissection in Breast Cancer With Positive Sentinel Lymph Node
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: PROCEDURE: Sentinel Lymph Node Biopsy|PROCEDURE: Intraoperative Pathological Examination|PROCEDURE: Axillary Lymph Node Dissection|PROCEDURE: Pathological Evaluation|DRUG: Adjuvant Systemic Therapy|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: rhBMP-2 vs Autologous Bone Grafting for the Treatment of Non-union of the Docking Site in Tibial Bone Transport
Status: UNKNOWN
Conditions: Pseudarthrosis
Interventions: DEVICE: rhBMP-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Pharmacokinetics Study in Participants With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: LY2189102|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-Dose Nedaplatin (CDGP:Cis-Diammine-Glycolatoplatinum)/5-FU Combined With Radiation for Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer|Squamous Cell Carcinoma
Interventions: DRUG: CDGP/5-FU combined with radiation|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yoga Nidra and Pain After Caesarean Section
Status: RECRUITING
Conditions: Caesarean Section|Yoga
Interventions: BEHAVIORAL: yoga nidra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy Study of Lucanthone When Used in Combination With Temozolomide(TMZ) and Radiation to Treat Glioblastoma Multiforme(GBM)
Status: TERMINATED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Lucanthone|DRUG: Temozolomide (TMZ)|RADIATION: Radiation|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GLPG0778: Multiple Ascending Oral Doses, Pharmacokinetic, Safety, and Pharmacodynamic Study
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG0778|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Exploring New and Next Generation Ultrasound Technologies for Medical Education, Patient Care, and New Indications
Status: WITHDRAWN
Conditions: Portable Ultrasound
Interventions: DIAGNOSTIC_TEST: Phillips Lumify Diagnostic Ultrasound System|OTHER: Surveys
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Drug-drug Interaction of BI 201335 and Microgynon
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: levonorgestrel|DRUG: Ethinylestradiol|DRUG: levonorgestrel|DRUG: BI 201335|DRUG: Ethinylestradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decision Support Intervention Adapted for HIV Pre-Exposure Prophylaxis for Adoption and Adherence for Black Canadians
Status: UNKNOWN
Conditions: HIV/AIDS
Interventions: BEHAVIORAL: Decision Support Aid and PrEP for Black Canadians
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessing Safety and Efficacy of Sintilimab and Metformin Combination Therapy in SCLC
Status: UNKNOWN
Conditions: Small-cell Lung Cancer|Small Cell Lung Carcinoma|Small Cell Lung Cancer Recurrent|Small Cell Lung Cancer Extensive Stage
Interventions: DRUG: PD-1 inhibitor|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Frequency of Undetectable Minimal Residual Disease (uMRD) in Adult Participants With Chronic Lymphocytic Leukemia (CLL) Receiving Oral Venetoclax Tablets ± Intravenously (IV) Infused Rituximab in Routine Clinical Practice in Japan
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Carbonic Anhydrase Antagonism in Subarachnoid Hemorrhage
Status: WITHDRAWN
Conditions: Acute Cerebrovascular Accident|Vasospasm
Interventions: DRUG: Acetazolamide|DRUG: Nimodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Variations of Pleural and Esophageal Pressures Under Mechanical Ventilation After Lung Transplantation
Status: COMPLETED
Conditions: Respiratory Disease
Interventions: OTHER: Measurement of oesophageal pressure and pleural pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Adding Vertical Correction to Scapular Recognition on Patients With Frozen Shoulder
Status: COMPLETED
Conditions: Frozen Shoulder
Interventions: OTHER: Dynamic Scapular Recognition exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Additional Clofazimine on Erythema Nodosum Leprosum (ENL) Reactions in Leprosy
Status: COMPLETED
Conditions: Borderline Lepromatous Leprosy|Lepromatous Leprosy
Interventions: DRUG: Clofazimine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Continuous Glucose Monitoring by Subcutaneous Measurement Compared to Frequent Point of Care Measurement by Accu Chek in Critically Ill Patients
Status: COMPLETED
Conditions: Hyperglycaemia|Hypoglycaemia
Interventions: DEVICE: Freestyle Navigator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: This Study in Healthy Men Tests How Different Doses of BI 1265162 Are Taken up in the Body and How Well They Are Tolerated.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1265162|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of the VOMS Tool With Military Personnel to Track mTBI Recovery and RTD Status
Status: COMPLETED
Conditions: Mild Traumatic Brain Injury
Interventions: DIAGNOSTIC_TEST: Vestibular Ocular Motor Screening Tool (VOMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Efficacy of Erector Spinae Plane Block Versus Infraclavicular Subomohyoid Block in Shoulder Surgery
Status: UNKNOWN
Conditions: Postoperative Pain|Shoulder Pain
Interventions: PROCEDURE: Erector spinae block|PROCEDURE: Infraclavicular subomohyoid (ISO) block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Longitudinal Sample Collection to Investigate Adaptation and Evolution of Ovarian High-grade Serous Carcinoma
Status: RECRUITING
Conditions: Ovarian Cancer|High Grade Serous Carcinoma|Carcinosarcoma, Ovarian|Fallopian Tube Cancer|Primary Peritoneal Carcinoma|BRCA1 Mutation|BRCA2 Mutation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of a Birth Dose of GlaxoSmithKline Biologicals' 251154 Vaccine
Status: WITHDRAWN
Conditions: Infections, Rotavirus
Interventions: BIOLOGICAL: 251154 vaccine|BIOLOGICAL: Infanrix hexa™|BIOLOGICAL: Synflorix™|BIOLOGICAL: Rotarix™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ph II Study of Wkly Topotecan + Bevacizumab in Plat. Resistant/Recurrent Gyn Cancers
Status: COMPLETED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Cancer
Interventions: DRUG: Topotecan|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arsenic Trioxide With Ascorbic Acid and Melphalan for Myeloma Patients
Status: COMPLETED
Conditions: Multiple Myeloma|Stem Cell Transplantation
Interventions: DRUG: Arsenic Trioxide|DRUG: Melphalan|DRUG: Ascorbic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect Of Rosiglitazone On Carotid Intima Media Thickness In Patients With Insulin Resistance Syndrome And/Or Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Rosiglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Resection Versus Microwave Ablation for Resectable Colorectal Cancer Liver Metastases
Status: TERMINATED
Conditions: Colorectal Neoplasms|Neoplasm Metastasis|Hepatic Neoplasms
Interventions: PROCEDURE: Microwave ablation|PROCEDURE: Hepatic resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: SYR-472|DRUG: SYR-472|DRUG: SYR-472|DRUG: SYR-472|DRUG: Placebo|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interest of Medical Hypnosis in Anxious Patients Treated by Radiotherapy
Status: RECRUITING
Conditions: Solid Tumor
Interventions: OTHER: Relaxation with music listening and medical hypnosis during radiotherapy treatment:|OTHER: Relaxation with music listening during radiotherapy treatment:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of the CGuard™ Carotid Stent System in Carotid Artery Stenting
Status: RECRUITING
Conditions: Carotid Artery Stenosis
Interventions: DEVICE: CGuard Carotid Stent implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PCT Guided Stopping of Antibiotic Therapy in Children With Sepsis
Status: COMPLETED
Conditions: Sepsis|Septic Shock|Antibiotic Use|Procalcitonin|PCT|Antimicrobial Resistance|AMR
Interventions: BEHAVIORAL: PCT group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Anonymized Data Collection From the CS6BP for Heart Arrythmias Measurements
Status: COMPLETED
Conditions: Heart Arrythmias
Interventions: DEVICE: ECG Holter and investigational device recordings for the purpose of developing Continuous Measurement of Heart Arrythmias
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Induction PD-1 Blockade (Nivolumab) in Patients With Surgically Complete Resectable Mismatch Repair Deficient Endometrial Cancer (NIVEC)
Status: RECRUITING
Conditions: Endometrial Neoplasms|Endometrial Cancer
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: rTMS With and Without Text4Support for the Treatment of Resistant Depression.
Status: RECRUITING
Conditions: Depressive Disorder, Treatment-Resistant
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)|DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS) Plus Text4Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does McGRATH® MAC Videolaryngoscope Decrease the Number of People Required to Perform Intubation During Anesthesia ?
Status: COMPLETED
Conditions: Anesthesia
Interventions: DEVICE: Laryngoscope with video|DEVICE: Laryngoscope without video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: MM-302 Plus Trastuzumab vs. Chemotherapy of Physician's Choice Plus Trastuzumab in HER2-Positive Locally Advanced/Metastatic Breast Cancer Patients
Status: TERMINATED
Conditions: Breast Cancer|HER2 Positive Breast Cancer
Interventions: DRUG: MM-302|DRUG: Gemcitabine|DRUG: Capecitabine|DRUG: Vinorelbine|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evolution of the Heart Function When Monitoring Immunotherapies Anti-cancerous Inhibiting PD-1
Status: RECRUITING
Conditions: Melanoma|Non-small Cell|Lung Cancer
Interventions: DRUG: Nivolumab|DEVICE: MRI|BIOLOGICAL: BLOOD SAMPLES|DEVICE: trans-thoracic echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pilot Study Evaluating the Optimization of the ORBEYE Blue Light Filter During Fluorescence-Guided Resection of Gliomas
Status: UNKNOWN
Conditions: Malignant Glioma of Brain
Interventions: DIAGNOSTIC_TEST: 5ALA exoscopic fluorescence filter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effect of Preoperative Carbohydrate Loading on Post-operative Insulin Resistance After Donor Hepatectomy.
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Maltodextrine|OTHER: overnight fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Combination Therapy of Thymalfasin and Entecavir in HBeAg-positive ETV-experienced Patients
Status: UNKNOWN
Conditions: Chronic Hepatitis b
Interventions: DRUG: Thymosin Alpha1|DRUG: Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Accelerated Partial Breast Irradiation Following Lumpectomy for Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Carcinoma, Ductal
Interventions: RADIATION: Intra-Operative Radiotherapy (IORT)|PROCEDURE: Lumpectomy|RADIATION: Whole Breast Radiotherapy|RADIATION: Intracavitary Brachytherapy|RADIATION: Accelerated External Beam 3-D Conformal Radiotherapy|RADIATION: Stereotactic APBI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-surgical Intervention for Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome, Susceptibility to
Interventions: DEVICE: Kinesio 12 inch Tape|DEVICE: Kinesio 4 inch Tape|DEVICE: Cock up Splint and Lumbrical exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effectiveness And Safety Of Two Protocols For The Treatment Of Erectile Dysfunction With Low-Density Shock Waves
Status: UNKNOWN
Conditions: Erectile Dysfunction
Interventions: PROCEDURE: Low-Intensity Extracorporeal Shock Wave Therapy (Li-ESWT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof-of-concept Trial of IVA337 in Diffuse Cutaneous Systemic Sclerosis
Status: COMPLETED
Conditions: Scleroderma, Diffuse|Diffuse Cutaneous Systemic Sclerosis
Interventions: DRUG: IVA337|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of AC-3933 in Adults With Mild to Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: AC-3933|DRUG: AC-3933|OTHER: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Heparin Dosing Regimens for Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Postoperative Hemorrhage
Interventions: DRUG: Heparin|DRUG: HH or high heparin|DRUG: heparin concentration HC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: rhTPO Combining Dexamethasone Versus High-dose Dexamethasone for Initial Treatment of ITP
Status: COMPLETED
Conditions: Purpura|Idiopathic Thrombocytopenic Purpura
Interventions: DRUG: recombinant human thrombopoietin (rhTPO); dexamethasone|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Teenage/Young Adults and Paediatric Patients With ROS1 Gene Fusion-positive Cancers.
Status: RECRUITING
Conditions: Solid Tumor|Haematological Malignancy|Malignancy|Malignant Neoplasm|Lymphoproliferative Disorders|Neoplasms by Histologic Type|Neoplasms by Site|Cancer|Brain Neoplasms|Melanoma|Glioma
Interventions: DRUG: Entrectinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Quality of Life for Nursing Home Residents
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: BEHAVIORAL: Activity matched to interest|BEHAVIORAL: Activity matched to function|BEHAVIORAL: Activity matched to both interest and function
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Safety and Efficacy of Deoxycholic Acid Injection (ATX-101) in the Reduction of Submental Fat
Status: COMPLETED
Conditions: Moderate or Severe Submental Fullness
Interventions: DRUG: Deoxycholic acid injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of the Effect of Liraglutide on Weight Loss and Gastric Functions in Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Liraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging of Apoptosis in Chronic Obstructive Pulmonary Disease (COPD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: RADIATION: SPECT-CT imaging|DRUG: AxV-128/Tc
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: IGF-1 and Bone Loss in Women With Anorexia Nervosa
Status: COMPLETED
Conditions: Anorexia Nervosa|Osteopenia|Osteoporosis
Interventions: DRUG: rhIGF-1|DRUG: Risedronate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Baricitinib and Omeprazole in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Baricitinib|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: XH-30002 Capsule Combined With Afatinib Tablets for the Treatment of Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: XH-30002 capsule|DRUG: Afatiinb tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blind Child Melatonin Treatment Study
Status: TERMINATED
Conditions: Blindness
Interventions: DIETARY_SUPPLEMENT: Melatonin|DIETARY_SUPPLEMENT: Melatonin|BIOLOGICAL: Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effects of Two Foot and Ankle Splints for Foot Pain
Status: COMPLETED
Conditions: Plantar Fasciitis
Interventions: DEVICE: Dynamic elastomeric fabric orthoses (DEFO)|DEVICE: Off -the-shelf triplanar orthoses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Study of Crenolanib, a Selective and Potent Inhibitor of PDGFR, for the Treatment of Adult Gliomas
Status: TERMINATED
Conditions: Glioma
Interventions: DRUG: Crenolanib (CP-868,596)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)
Status: UNKNOWN
Conditions: Fuchs' Endothelial Corneal Dystrophy|Bullous Keratopathy|Iridocorneal Endothelial Syndrome|Posterior Polymorphous Dystrophy|Endothelial Dysfunction
Interventions: OTHER: Endothelial Keratoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palliative Care Consultation to Improve Communication for Patients Considering Surgery for a Pancreatic Neoplasm
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Neoplasm
Interventions: OTHER: Best Practice|PROCEDURE: Palliative Care Consultation|OTHER: Survey Administration|OTHER: Tumor Board Review
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A SINGLE-DOSE, 2-ARM, PHARMACOKINETIC STUDY OF PF-06439535 (CN) AND EUROPEAN UNION SOURCED BEVACIZUMAB IN CHINESE HEALTHY MALE VOLUNTEERS
Status: WITHDRAWN
Conditions: Pharmacokinetics
Interventions: DRUG: PF-06439535 (CN)|DRUG: bevacizumab - EU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Relevance of the Activ'Dos App for Chronic Low Back Pain Patients
Status: TERMINATED
Conditions: Chronic Disease|Lumbago
Interventions: OTHER: ACTIV'DOS group|OTHER: Usual practise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Growth Hormone Treatment of Children Diagnosed of Intrauterine Growth Retardation
Status: COMPLETED
Conditions: Foetal Growth Problem|Small for Gestational Age
Interventions: DRUG: somatropin|DRUG: somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Experiences From Pregnancy and Post-partum Period in Women With a History of Eating Disorders.
Status: ENROLLING_BY_INVITATION
Conditions: Pregnancy Related|Eating Disorders|Bulimia Nervosa|Binge-Eating Disorder|Post Partum Depression
Interventions: OTHER: Pregnancy|OTHER: Post-Partum
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Research on Acute Intermittent Porphyria and the Use of Carbohydrate-Rich Diet as a Treatment
Status: RECRUITING
Conditions: Porphyria, Acute Intermittent
Interventions: OTHER: Carbohydrates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Efficacy and Safety of Therapy With COVID-19 Convalescent Plasma in Subjects With Severe COVID-19 (IPCO)
Status: UNKNOWN
Conditions: Severe COVID-19
Interventions: BIOLOGICAL: COVID-19 convalescent plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Inflammatory Disease, Lifestyle and Treatment Response
Status: COMPLETED
Conditions: Autoimmune Diseases|Inflammatory Bowel Diseases|Crohn Disease (CD)|Colitis, Ulcerative (UC)|Arthritis, Rheumatoid (RA)|Spondylarthropathies|Arthritis, Psoriatic (PsA)|Psoriasis|Hidradenitis Suppurativa (HS)|Uveitis
Interventions: OTHER: Primary exposure variable|OTHER: Other (exploratory) exposure variables
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Valsartan and Amlodipine (± HCTZ) in Adults With Moderate, Inadequately Controlled Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Amlodipine|DRUG: Olmesartan medoxomil|DRUG: Amlodipine+valsartan|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Ergometer Training With Telemonitoring in Patients With Chronic Obstructive Pulmonary Disease (COPD) After Exacerbation
Status: COMPLETED
Conditions: COPD
Interventions: OTHER: Ergometer Training|OTHER: Motivation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Single Day or Single Dose Famciclovir for the Treatment of Recurrent Herpes Labialis
Status: COMPLETED
Conditions: Recurrent Herpes Labialis
Interventions: DRUG: Famciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Increased Oxygenation in the Air During Endurance Training in Stable Angina Pectoris Patients
Status: COMPLETED
Conditions: Angina Pectoris
Interventions: BEHAVIORAL: Hypoxic interval training|BEHAVIORAL: Normoxic interval training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Creatine Supplementation Improve Body Composition and Physical Function in Rheumatoid Arthritis Patients?
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DIETARY_SUPPLEMENT: Creatine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT