pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Goal-directed Analgesia Using ANI During General Anesthesia in Children With Moyamoya Disease
Status: RECRUITING
Conditions: Pain
Interventions: DEVICE: ANI (Analgesia/Nociception Index) monitoring|DEVICE: standard monitoring|DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Preemptive Epidural Analgesia in Labor on Cytokine Production
Status: COMPLETED
Conditions: Obstetric Pain
Interventions: PROCEDURE: Preemptive epidural analgesia|DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CAR-BCMA, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against BCMA in Subjects With Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma|Relapse Multiple Myeloma
Interventions: BIOLOGICAL: CAR-BCMA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Predictive Blood Biomarkers of Recurrent Urinary Tract Infections
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: PROCEDURE: Collection of blood samples|OTHER: Collection of fecal samples|OTHER: Collection of urine samples|OTHER: Collection of vaginal swaps
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Usefulness of Transcutaneous Capnography to Assess Residual Hypoventilation in Obesity-Hypoventilation Syndrom Treated by Non Invasive Ventilation at Home : a Prospective Study
Status: COMPLETED
Conditions: Obesity Hypoventilation Syndrome
Interventions: OTHER: No Interventional study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Equivalence Study of Generic Ingenol Mebutate Gel 0.015% and Picato Gel 0.015% in Subjects With Actinic Keratosis
Status: COMPLETED
Conditions: ACTINIC KERATOSIS
Interventions: DRUG: Ingenol Mebutate (Picato®)|DRUG: Generic Ingenol Mebutate|DRUG: Vehicle Foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Atezolizumab (Anti-PD-L1 Antibody) in Combination With Enzalutamide in Participants With Metastatic Castration-Resistant Prostrate Cancer (mCRPC) After Failure of an Androgen Synthesis Inhibitor And Failure of, Ineligibility For, or Refusal of a Taxane Regimen
Status: COMPLETED
Conditions: Prostatic Neoplasms, Castration-Resistant
Interventions: DRUG: Atezolizumab|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Nepafenac as Supplement for Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Topical Gutt Nepafenac 0.1%|PROCEDURE: Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NAsal Polyps: Inflammatory & Molecular Phenotyping of Responders to Benralizumab
Status: UNKNOWN
Conditions: Nasal Polyps
Interventions: BIOLOGICAL: Benralizumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: O2 Transport and Utilization in Health and Lung Disease
Status: WITHDRAWN
Conditions: COPD|Tetrahydrobiopterin Deficiency|Oxidative Stress
Interventions: DRUG: Tetrahydrobiopterin|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Single Group Study to Evaluate the Effects of a Probiotic Vaginal Suppository on Vaginal Health.
Status: COMPLETED
Conditions: Vaginal Health|Vaginal pH
Interventions: DIETARY_SUPPLEMENT: Flora Power Probiotic Vaginal Suppository
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultrasonographic Measurement of Internal Jugular Vein as a Predictor of Hypotension Following Spinal Anesthesia
Status: COMPLETED
Conditions: Spinal Anesthetics Causing Adverse Effects in Therapeutic Use|Hypotension Postprocedural
Interventions: OTHER: spinal anesthesia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Everolimus in de Novo Kidney Transplant Recipients of ECD or AKI Donors
Status: UNKNOWN
Conditions: Transplantation of Kidney|Expanded Criteria Donor|ECD
Interventions: DRUG: Everolimus + low dose cyclosporin A + prednisolone|DRUG: Standard immunosupressive regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychiatric Orders in Psychoanalytic Treatment of ASD
Status: ACTIVE_NOT_RECRUITING
Conditions: PTSD|Autism Spectrum Disorder High-Functioning|OCD|Agoraphobia With Panic Attacks|Depression, Unipolar|Depression, Anxiety|Depression and Suicide|Depression, Reactive|Depression; Psychoneurotic|Depression Anxiety Disorder|Panic Disorder With Agoraphobia, Severe Agoraphobic Avoidance and Mild Panic Attacks|Anxiety Disorders|ADHD - Combined Type|Borderline Personality Disorder|Social Anxiety Disorder|Avoidant Personality Disorder|Stockholm Syndrome|Grief|Separation Insecurity
Interventions: DIAGNOSTIC_TEST: Psychoanalysis|DRUG: sertraline 50mg|DRUG: Duloxetine 20 MG|BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Relapse-Prevention Study With Levomilnacipran ER (F2695 SR) in Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Depression|Major Depressive Disorder
Interventions: DRUG: Levomilnacipran ER|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of MP-513 in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Teneligliptin 10mg|DRUG: Teneligliptin 20 mg|DRUG: Teneligliptin 40 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Nonsteroidal Anti-Inflammatory Drugs in Recurrence of Spondyloarthritis Patients After Remission
Status: RECRUITING
Conditions: Axial Spondyloarthritis
Interventions: DRUG: To withdraw NSAIDs therapy|DRUG: To continue NSAIDs therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single and Multiple Dosing Study Targeting Biparatopic Antibody CD38 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: TNB-738|DRUG: TNB-738
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MALIBU Trial - Combination of Ibrutinib and Rituximab in Untreated Marginal Zone Lymphomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Marginal Zone Lymphoma|Nodal Marginal Zone Lymphoma|Splenic Marginal Zone Lymphoma
Interventions: DRUG: Ibrutinib|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: General Anesthesia With and Without Muscle Relaxation and Muscle Strength Recovery
Status: UNKNOWN
Conditions: Rocuronium|Muscle Weakness|General Anaesthesia
Interventions: DRUG: Rocuronium|PROCEDURE: General anesthesia for surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Pertuzumab, Trastuzumab, Hyaluronidase-zzxf and Enzalutamide for Treatment of Metastatic Castration-Resistant Prostate Cancer
Status: RECRUITING
Conditions: Castration-Resistant Prostate Carcinoma|Stage IVB Prostate Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Echocardiography|DRUG: Enzalutamide|DRUG: Hyaluronidase-zzxf/Pertuzumab/Trastuzumab|PROCEDURE: Magnetic Resonance Imaging|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Denervation in Refractory Hypertension
Status: TERMINATED
Conditions: Hypertension|Resistant to Conventional Therapy
Interventions: DEVICE: Renal denervation (Symplicity® Catheter System™)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study of Somatropin Treatment in Children
Status: COMPLETED
Conditions: Growth Hormone (GH) Deficiency|Short Stature Homeobox Containing Gene (SHOX) Deficiency|SHOX Deficiency-related Disorder|Non-GH-deficient Growth Disorders
Interventions: DRUG: Somatropin (recombinant deoxyribonucleic acid [rDNA] origin)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Roflumilast or Azithromycin to Prevent COPD Exacerbations (RELIANCE)
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease Severe|Chronic Bronchitis
Interventions: DRUG: Roflumilast|DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effects of Motor Imagery Training and Physical Practice on Upper Extremity Motor Function in Patients With Stroke
Status: UNKNOWN
Conditions: Stroke
Interventions: OTHER: Group 1 Motor imagery and Bobath Therapeutic Approach (BTA+MI)|OTHER: Group 2 Motor imagery, Bobath Therapeutic Approach and Physical practice (BTA+MI+PP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Application of Sulforaphane-containing Broccoli Sprout Extracts on Radiation Dermatitis
Status: COMPLETED
Conditions: Breast Cancer|Dermatitis
Interventions: OTHER: Sulforaphane-containing broccoli sprout extracts (active agent)|DEVICE: Vehicle (inactive control)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Therapeutic Effects of Equine-Assisted Psychotherapy
Status: COMPLETED
Conditions: Aggression|Stress|Psychopathy|Empathy
Interventions: BEHAVIORAL: Equine-Assisted Psychotherapy|BEHAVIORAL: Equine-Assisted Activities|OTHER: Placebo-control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Tirzepatide in Patients With Obesity or Overweight Who Have High Risk Early Breast Cancer and Are ctDNA+
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Breast Neoplasms
Interventions: DRUG: Tirzepatide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Clinical Trial of GEN2-Recombinant COVID-19 Vaccine (CHO Cells) in Healthy People Aged 18 and Above
Status: UNKNOWN
Conditions: COVID-19 Pneumonia
Interventions: BIOLOGICAL: Experimental Vaccine 1|BIOLOGICAL: Experimental Vaccine 2|BIOLOGICAL: Experimental Vaccine 3|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of LM-305 in Patients With Relapsed or Refractory Multiple Myeloma (RRMM) and Other Plasma Cell Diseases
Status: WITHDRAWN
Conditions: Relapsed or Refractory Multiple Myeloma|Other Plasma Cell Diseases
Interventions: DRUG: LM-305|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1a Trial to Evaluate the Safety and Immunogenicity of a SARS-CoV-2 mRNA Chimera Vaccine Against COVID-19
Status: NOT_YET_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: RQ3013|BIOLOGICAL: Comirnaty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity of a Candidate Tuberculosis (TB) Vaccine in Healthy HIV Negative Adolescents
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: GSK's investigational vaccine 692342|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Long-Term, Placebo-Controlled X-Ray Study Investigating the Safety and Efficacy of SD-6010 in Subjects With Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: SD-6010|DRUG: SD-6010|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise and Flax-Based Nutritional Supplementation for Lowering Cholesterol
Status: COMPLETED
Conditions: Metabolic Syndrome|Osteoporosis
Interventions: DIETARY_SUPPLEMENT: Flax lignan|BEHAVIORAL: Exercise (walking)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: P3 (Prepared, Protected, emPowered)
Status: COMPLETED
Conditions: Sexually Transmitted Diseases|Safe Sex|Adherence, Medication
Interventions: BEHAVIORAL: P3|BEHAVIORAL: P3+|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Validation of HepaFat-Scan for Noninvasive Measurement of Steatosis in Youth
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease
Interventions: PROCEDURE: Magnetic Resonance Imaging (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pembrolizumab in MMR-Proficient Metastatic Colorectal Cancer Pharmacologically Primed to Trigger Hypermutation Status
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Neoplasms|Microsatellite Instability
Interventions: DRUG: temozolomide (induction),|BIOLOGICAL: pembrolizumab (treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycemic and Satiety Response Study of Fibre-Enriched Pudding Products
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: Yellow Mustard Gum Fibre|OTHER: Soluble Flaxseed Gum Fibre|OTHER: Fenugreek Gum Fibre
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Between Ondansetron 8 mg and Lidocain 40 mg in Preventing Pain Due to Propofol Injection
Status: COMPLETED
Conditions: General Anesthesia With Propofol
Interventions: DRUG: Ondansetron 8 mg|DRUG: Lidocain 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: S1300: Pemetrexed Disodium With or Without Crizotinib in Treating Patients With Stage IV Non-Small Cell Lung Cancer That Has Progressed After Crizotinib
Status: TERMINATED
Conditions: Adenocarcinoma of the Lung|Large Cell Lung Cancer|Recurrent Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: DRUG: crizotinib|DRUG: pemetrexed disodium|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vagus Nerve Preservation and Chronic Cough in Non-small Cell Lung Cancer Surgery
Status: RECRUITING
Conditions: Lung Cancer|Vagus Nerve Injuries|Cough
Interventions: PROCEDURE: Pulmonary branch of vagus nerve preserved|PROCEDURE: Pulmonary branch of vagus nerve not preserved
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Iron Status on Occurrence of Non-transferrin-bound Iron (NTBI) in Serum in Response to an Oral Iron Load
Status: UNKNOWN
Conditions: Effect of Iron Status on Occurrence of NTBI
Interventions: DIETARY_SUPPLEMENT: Ferrous Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Continuous Glucose Monitoring in Diabetes and Prediabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|PreDiabetes|Obesity
Interventions: DEVICE: DEXCOM G6 RT-CGM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Atrophic Nonunion Fractures by Autologous Mesenchymal Stem Cell Percutaneous Grafting
Status: WITHDRAWN
Conditions: Nonunion Fracture
Interventions: BIOLOGICAL: Mesenchymal Stem Cells|OTHER: Culture medium without MSC.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First Adult Safety Trial on Nasal Live Attenuated B. Pertussis Vaccine
Status: COMPLETED
Conditions: Pertussis
Interventions: BIOLOGICAL: BPZE1|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Role of Lung Ultrasound in Weaning From Mechanical Ventilation in Postoperative Neurosurgical ICU Patients
Status: COMPLETED
Conditions: Intensive Care (ICU)
Interventions: DEVICE: lung ultrasound|OTHER: routine tools
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Antiemetic Fosaprepitant To Remedy Nausea and Vomiting
Status: NOT_YET_RECRUITING
Conditions: Nausea and Vomiting|Nausea|Vomiting
Interventions: DRUG: Fosaprepitant 150 mg|DRUG: Ondansetron 4 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Study Of CP-690,550 In Subjects With Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: CP-690,550|DRUG: CP-690,550
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repeated Subcutaneous Administration of ABvac40 in Mild to Moderate Alzheimer's Disease Patients
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: ABvac40|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Treatment Compliance, Efficacy and Safety of an Improved Deferasirox Formulation (Granules) in Pediatric Patients (2-<18 Years Old) With Iron Overload
Status: COMPLETED
Conditions: Transfusion-dependent Anemia
Interventions: DRUG: Deferasirox granule formulation|DRUG: Deferasirox DT formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II/III Tolerance and Efficacy Study of RSD1235 in Patients With Atrial Flutter
Status: COMPLETED
Conditions: Atrial Flutter
Interventions: DRUG: Vernakalant Injection 20 mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Microneurography (MNG) Study of VX-150 in Healthy Participants
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Placebo|DRUG: VX-150
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Prophylactic Antibiotics on Intra-Operative Culture Results
Status: COMPLETED
Conditions: Infection|Arthroplasty
Interventions: PROCEDURE: Prophylactic Antibiotics|PROCEDURE: Control Antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Pelvic Adjuvant Radiation Therapy in Cancers of the Uterus II
Status: UNKNOWN
Conditions: Endometrial Cancer
Interventions: RADIATION: Conventional Fractionation|RADIATION: Hypofractionation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Interactive Effects of Delta-9-Tetrahydrocannabinol and Pregnenolone
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Active Delta-9-THC|DRUG: Active Pregnenolone|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cisplatin, Intensity-Modulated Radiation Therapy, and Pembrolizumab in Treating Patients With Stage III-IV Head and Neck Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7|Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7|Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7|Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVA Hypopharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7|Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7|Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVB Hypopharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVB Laryngeal Squamous Cell Carcinoma AJCC v7|Stage IVB Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7|Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7
Interventions: DRUG: Cisplatin|RADIATION: Intensity-Modulated Radiation Therapy|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy/Safety Study of Deferiprone Compared to Deferasirox in Paediatric Patients
Status: COMPLETED
Conditions: Chronic Iron Overload
Interventions: DRUG: Deferiprone|DRUG: Deferasirox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antiviral Cellular Therapy for Enhancing T-cell Reconstitution Before or After Hematopoietic Stem Cell Transplantation
Status: ACTIVE_NOT_RECRUITING
Conditions: Cytomegalovirus Infections|Adenovirus Infection|EBV Infection
Interventions: BIOLOGICAL: Virus Specific T-cell (VST) infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromarkers Identification in Major Depressive Disorder Based on Monitoring Measures
Status: UNKNOWN
Conditions: Depression
Interventions: DEVICE: single channel "Multiway Coil®"|DEVICE: Two channels "Multiway stimulator coil®" (Brainsway Ltd.)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison Between Analog Neurocognitive Tests Conducted by a Trained Test Leader Versus Self-administered Digital Tests
Status: COMPLETED
Conditions: Neurocognitive Decline|Feasibility|Costs|Interviews
Interventions: DIAGNOSTIC_TEST: Analog testing conducted by a trained test leader using, ISPOCD test battery|DIAGNOSTIC_TEST: self-administered Mindmore digital cognitive screening battery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study of JNJ-67484703 in Participants With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: JNJ-67484703|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Axitinib in R/M Salivary Gland Cancers of the Upper Aerodigestive Tract - SGC-AX14
Status: COMPLETED
Conditions: Salivary Gland Cancers
Interventions: DRUG: Axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heart Failure Polypill at a Safety Net Hospital
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction|HIV Infections
Interventions: DRUG: Heart failure polypill|DRUG: Control Rx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Damages From Macular Grasping During Vitrectomy Comparing Traditional and 3D Microscope
Status: COMPLETED
Conditions: Comparison of 3D Visualization and Microscope for VR Surgery
Interventions: DEVICE: Macular surgery with NGENUITY surgical display system|DEVICE: Macular surgery with standard operating microscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel Plus Carboplatin With or Without Endostar in Patients With Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Advanced Non-small Cell Lung Cancer
Interventions: DRUG: Endostar(Recombinant Human Endostatin Injection)|DRUG: paclitaxel-carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fludarabine, Cyclophosphamide, and Rituximab or Alemtuzumab in Treating CLL2007 CLL 2007 FMP
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: Campath|BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temozolomide Plus Bevacizumab in Supratentorial Glioblastoma in 70 Years and Older Patients With an Impaired Functional Status
Status: COMPLETED
Conditions: Glioblastoma Multiforme|Primary Brain Tumor
Interventions: DRUG: Temozolomide|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Circulating NEP and NEP Inhibition Study in Heart Failure With Preserved Ejection Fraction
Status: COMPLETED
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: Entresto™ 49Mg-51 mg tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pulmonary Rehabilitation in Patients With Idiopathic Pulmonary Fibrosis (IPF)
Status: TERMINATED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Nintedanib|OTHER: Pulmonary rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Clinical Study of Assessing HER-2 Expression in Gastric Cancer With Extra Tumor Tissue Paraffin Blocks Using Immunohistochemistry
Status: UNKNOWN
Conditions: Gastric Cancer Surgical Specimens,18-80 Years Old, at Least Two Tumor Tissue Blocks
Interventions: PROCEDURE: choose two tumor tissue paraffin blocks
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Testing the Combination of XL184 (Cabozantinib), Nivolumab, and Ipilimumab for Poorly Differentiated Neuroendocrine Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Large Cell Neuroendocrine Carcinoma|Metastatic Neuroendocrine Carcinoma|Metastatic Neuroendocrine Neoplasm|Metastatic Small Cell Neuroendocrine Carcinoma
Interventions: DRUG: Cabozantinib S-malate|BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alcohol Use Disorders (AUDs) and Post-traumatic Stress Disorder (PTSD) Treatment for Victims of Partner Violence
Status: COMPLETED
Conditions: PTSD|Substance Use Disorders
Interventions: BEHAVIORAL: Integrated psychotherapy for PTSD and substance use|BEHAVIORAL: 12-step based supportive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study on Mortality and Outcome of Patients Hospitalized for Subarachnoid Hemorrhage of Aneurysmal Origin in Martinique Between 2013 and 2021
Status: RECRUITING
Conditions: Subarachnoid Hemorrhage of Aneurysmal Cause
Interventions: OTHER: Usual patient care for patients hospitalized for subarachnoid hemorrhage of aneurysmal origin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SGI-110 in Patients With Myelodysplastic Syndromes (MDS) or Acute Myelogenous Leukemia (AML)
Status: COMPLETED
Conditions: MDS|CMML|AML
Interventions: DRUG: SGI-110|DRUG: SGI-110
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Role of the FTO Gene in Reward System Activation in Obese and Healthy Subjects
Status: UNKNOWN
Conditions: Obesity|Eating Behavior
Interventions: PROCEDURE: Blood sampling for genetic analyse|BEHAVIORAL: Stroop test|OTHER: fMRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Manual Skills, Visual-Motor Integration and Participation of Children With and Without Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes|Hand Skills|Visual Motor Integration|Participation
Interventions: BEHAVIORAL: Beery- Buktenica Developmental Test of Visual Motor Integration|BEHAVIORAL: Jebsen Taylor Hand Function Test|DIAGNOSTIC_TEST: Participation and Environment Measure - Children and Youth
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vorinostat in Treating Women With Ductal Carcinoma in Situ of the Breast
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: vorinostat|GENETIC: protein expression analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|PROCEDURE: neoadjuvant therapy|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Bengali Dietary Salt Study to Control Blood Pressure
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: Low-salt educational programme|BEHAVIORAL: Low-salt Bangladeshi educational programme|BEHAVIORAL: Low-salt Bangladeshi educational programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Posterior Tibial Nerve Stimulation in Patients With Multiple Sclerosis Related Urge Incontinence
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: OTHER: Stoller's Afferent Nerve Stimulation (SANS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clofazimine in the Treatment of Pulmonary Mycobacterium Avium Complex (MAC)
Status: RECRUITING
Conditions: Mycobacterium Avium Complex
Interventions: DRUG: Clofazimine|OTHER: sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-130037 in Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: VVD-130037
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Paclitaxel, Carboplatin and Oral Metformin in the Treatment of Advanced Stage Ovarian Carcinoma
Status: UNKNOWN
Conditions: Epithelial Ovarian Carcinoma
Interventions: DRUG: Metformin|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fundus Effects of Repeated Low-Level Red-Light Therapy in Chinese Myopic Minors: A Randomized Controlled Clinical Trial
Status: RECRUITING
Conditions: Red Laser Light-Induced Retinopathy of Both Eyes (Diagnosis)
Interventions: DEVICE: Low-Intensity Red Light Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Personalized Management of Autoimmune Diseases With AI-Guided (GenAIS TM) Dietary Supplementation
Status: COMPLETED
Conditions: Autoimmune Diseases
Interventions: OTHER: Control group|OTHER: AI-Guided Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Liraglutide on Endothelial Function and Microvascular Blood Flow in Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Victoza®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hidradenitis Suppurativa Wound Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Hidradenitis Suppurativa (HS)
Interventions: COMBINATION_PRODUCT: methylene blue, gentian violet, and ovine forestomach wound dressings
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characteristics of Glargine in Type 2 Diabetics
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Placebo|DRUG: Insulin Glargine 0.5 u/kg body wt SC|DRUG: Insulin Glargine 1.0 u/kg body wt SC|DRUG: Insulin Glargine 1.5 u/kg body wt SC|DRUG: Insulin Glargine 2.0 u/kg body wt SC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Elucidating the Influence of Lactulose Intake on the Gut Microbiota Composition
Status: COMPLETED
Conditions: Changes in Gut Microbiota Composition After Lactulose Exposure
Interventions: DRUG: application of lactulose|OTHER: application of sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Modulating the Vaginal Microbiome After Implantation Failure
Status: COMPLETED
Conditions: Implantation Failure|Infertility, Female|Vaginal Flora Imbalance
Interventions: DRUG: Vivag Plus|DRUG: Placebo - Cap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Interactive Oral Care Lessons on Children Dental Health Practices
Status: NOT_YET_RECRUITING
Conditions: Dental Plaque
Interventions: BEHAVIORAL: Smile Smarts
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of the Efficacy of Oral Oxycodone and Oral Codeine in the Treatment of Postcraniotomy Pain
Status: COMPLETED
Conditions: Postcraniotomy Pain
Interventions: DRUG: Oxycodone|DRUG: Codeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin C to Reduce Morning Cardiovascular Risk
Status: COMPLETED
Conditions: Cardiovascular Risk Factor
Interventions: DIETARY_SUPPLEMENT: Vitamin C|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of the Pharmacokinetics and Pharmacodynamics of POSIPHEN® in Subjects With Amnestic Mild Cognitive Impairment
Status: TERMINATED
Conditions: Alzheimer's Disease|Amnestic Mild Cognitive Impairment
Interventions: DRUG: Posiphen® tartrate capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Virtual Reality Exercises in STroke Rehabilitation: A Multicentre Study (EVREST Multicentre)
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: OTHER: Recreational Activity|OTHER: Wii Gaming System Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Cryoanalgesia for Irreversible Pulpitis
Status: COMPLETED
Conditions: Pulpitis - Irreversible
Interventions: PROCEDURE: Cold Mepivacaine|PROCEDURE: Mepivacaine at room temperature
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Midpoint Transverse Process to Pleura Block and Thoracic Paravertebral Block
Status: COMPLETED
Conditions: Analgesia|Post Operative Pain
Interventions: PROCEDURE: paravertebral block group|PROCEDURE: Mid point transverse process block group|PROCEDURE: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective, Randomized Trial of Histoacryl Injection Versus Thrombin in the Control of Acute Gastric Variceal Bleeding
Status: UNKNOWN
Conditions: Ulcer, on Gastric Varices|Rebleeding From Gastric Varices
Interventions: DRUG: Thrombin|DRUG: Histoacryl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pan Asian Trial Comparing Efficacy and Safety of NN5401 and Biphasic Insulin Aspart 30 in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec/insulin aspart|DRUG: biphasic insulin aspart 30
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Study in Pediatric Subjects With Migraines (MK0462-083 AM1)
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: DRUG: rizatriptan benzoate (5 mg)|DRUG: rizatriptan benzoate (10 mg)|DRUG: Rizatriptan 5 mg Placebo|DRUG: Rizatriptan 10 mg Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of the Enseal Intrument for Laparoscopic Supracervical Hysterectomy
Status: COMPLETED
Conditions: Indications for Laparoscopic Supracervical Hysterectomy
Interventions: DEVICE: Sealing tissue with the Enseal device|PROCEDURE: Conventional supracervical hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Continuous Soluble Ferric Pyrophosphate (SFP) Iron Delivery Via Dialysate in Hemodialysis Patients
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DRUG: Soluble Ferric Pyrophosphate in liquid bicarbonate|DRUG: Placebo: Conventional liquid bicarbonate|DRUG: Erythrocyte Stimulating Agent (ESA)|DRUG: Intravenous (IV) Iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Low- and Moderate-intensity Statin and Clinical Outcome of Primary Prevention in Individuals Aged >75 Years: the SCOPE-75 RCT Study
Status: NOT_YET_RECRUITING
Conditions: Healthy Elderly Individuals With High LDL-cholesterol or Risk of Cardiovascular Disease
Interventions: DRUG: Low intensity statin|DRUG: Moderate intensity statin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Learn About the Study Medicine (Elranatamab) in Participants With Multiple Myeloma That Has Come Back After Responding to Treatment or Has Not Responded to Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Elranatamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of Epinephrine on Platelet Reactivity in Subjects Treated With Ticagrelor
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Ticagrelor 90mg|DRUG: Epinephrine|DRUG: Metoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Busulfan and Fludarabine Before Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer
Status: WITHDRAWN
Conditions: Anemia|Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases
Interventions: BIOLOGICAL: filgrastim|DRUG: busulfan|DRUG: fludarabine phosphate|DRUG: methotrexate|DRUG: tacrolimus|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maternal & Offspring Microbiome Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Pregnancy Related|Microbiome|Immune Function|Inflammation
Interventions: BEHAVIORAL: Fiber|BEHAVIORAL: Fermented Foods
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Personal Health Records and Elder Medication Use Quality
Status: COMPLETED
Conditions: Adverse Reaction to Drug|Health Behavior|Medication Adherence|Physician-Patient Relations
Interventions: BEHAVIORAL: Personal Health Record (PHR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prednisolone Administration in Patients With Unexplained REcurrent MIscarriages
Status: RECRUITING
Conditions: Recurrent Miscarriage|Recurrent Pregnancy Loss|Habitual Abortion|Miscarriage|Fertility Disorders
Interventions: DRUG: Prednisolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Benefits of Individualized Follow-up With a Sport-Health Professional in the Care of Patients With Chronic Respiratory Diseases
Status: NOT_YET_RECRUITING
Conditions: Chronic Respiratory Disease
Interventions: OTHER: Personalized follow-up and support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Optimalization of Nephroprotection Using Atorvastatin (Sortis)
Status: COMPLETED
Conditions: Chronic Kidney Disease|Proteinuria
Interventions: DRUG: atorvastatin (Sortis) 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Antioxidant in Endometriotic Women to Improve Intracytoplasmic Sperm Injection (ICSI)
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: ascorbate 1000mg, vitamin E 400, zinc and selenium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Inflammatory Mediators in Erythema Migrans
Status: COMPLETED
Conditions: Erythema Migrans
Interventions: DRUG: Doxycycline 7 days|DRUG: Doxycycline 14 days
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Initial Experience With Spatial Resynchronization Therapy in Patients With Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DEVICE: Spatial Resynchronization Therapy delivered by the MAX-SRS, external recording and stimulation device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caffeine Kinetics and CrossFit®-Specific Performance
Status: RECRUITING
Conditions: Supplementation|Sports Nutrition|Ergogenic Support|Discipline-specific Performance
Interventions: DIETARY_SUPPLEMENT: CAFMONO supplementation|DIETARY_SUPPLEMENT: CAFMIPS_1 supplementation|DIETARY_SUPPLEMENT: CAFMIPS_2 supplementation|DIETARY_SUPPLEMENT: Placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate Safety, Tolerability and Pharmacokinetics of AZD2423 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: AZD2423|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE