pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Safety, PK and Efficacy Study of CC-92480 Monotherapy and in Combination With Dexamethasone in Subjects With Relapsed and Refractory Multiple Myeloma (RRMM)
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: CC-92480|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Whether Spesolimab Helps People With Crohn's Disease Who Have Symptoms of Bowel Obstruction
Status: TERMINATED
Conditions: Fibrostenotic Crohn´s Disease
Interventions: DRUG: Spesolimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Epidurally Administered Ropivacaine Concentration on the Hemodynamic Parameters
Status: COMPLETED
Conditions: Epidural Anesthesia|Ropivacaine Concentration|Hemodynamics
Interventions: DRUG: 0.75% ropivacaine concentration|DRUG: 0.375% ropivacaine concentration|DRUG: 0.2% ropivacaine concentration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Surgeon Warm-up and Mental Visualisation During Robot-assisted Laparoscopic Surgery
Status: COMPLETED
Conditions: Cognitive Deficit in Attention|Musculoskeletal Strain|Fatigue|Surgery
Interventions: OTHER: Simulated exercises|OTHER: Mental Visualisation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Nebulized Fentanyl, Midazolam and Dexmedetomidine as a Premedication in Pediatric Dental Surgeries
Status: COMPLETED
Conditions: Dental Surgeries
Interventions: DRUG: fentanyl|DRUG: midazolam|DRUG: dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Antidepressive Effect of rTMS as add-on to ECT
Status: TERMINATED
Conditions: Depression
Interventions: DEVICE: Low frequency (1 hz) rTMS, as add-on to ECT|DEVICE: Sham-rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Evaluation of Direct Pulp Capping
Status: UNKNOWN
Conditions: Dental Pulp Capping|Dental Caries Extending to Pulp
Interventions: DRUG: Calcium Hydroxide (Ca(OH)2)|DRUG: Mineral Trioxide Aggregate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Imagine a Brighter Future: An Intervention to Improve Positive Emotions in Young People
Status: WITHDRAWN
Conditions: Depression|Anhedonia
Interventions: BEHAVIORAL: IMAGINE-POSITIVE|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection
Status: RECRUITING
Conditions: Osteoarthritis of the Knee
Interventions: OTHER: Autologous bone marrow aspirate concentrate (BMAC)|DRUG: Corticosteroid injections|OTHER: Crossover Autologous bone marrow aspirate concentrate (BMAC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: IMProving Adherence to Colonoscopy Through Teams and Technology
Status: RECRUITING
Conditions: Colon Cancer|Cancer Colorectal|Colorectal Cancer
Interventions: BEHAVIORAL: BPB, No PIN|BEHAVIORAL: BPB, PIN|BEHAVIORAL: No BPB, PIN|BEHAVIORAL: No BPB, No PIN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Mindfulness and Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: BEHAVIORAL: mindfulness training|BEHAVIORAL: non-mindfulness training|BEHAVIORAL: book-listening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gluteal Squeeze for Left Colon Distension
Status: TERMINATED
Conditions: Colorectal Neoplasms
Interventions: OTHER: Gluteal squeeze|OTHER: No squeeze
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Effects of Ghrelin on Alcohol Cue Reactivity and Craving
Status: COMPLETED
Conditions: Alcoholism
Interventions: DRUG: Ghrelin|DRUG: Ghrelin|DRUG: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Development and Initial Application of a Combined Exercise and Psychological Intervention Program for Patients After Esophagectomy
Status: NOT_YET_RECRUITING
Conditions: Esophageal Cancer|Exercise Training|Psychotherapy|Rehabilitation
Interventions: BEHAVIORAL: Exercise and Psychological Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Single Dose Escalation Study of CM383 in Healthy Volunteers
Status: NOT_YET_RECRUITING
Conditions: Alzheimer Disease
Interventions: BIOLOGICAL: CM383|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Geriatric-assessment Interventions to Address Functional Deficits in Older Adults w Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma|Myeloma|Disability Physical|Disabilities Multiple
Interventions: OTHER: Supportive care interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: De- Escalation and Stopping Treatment of Imatinib, Nilotinib or sprYcel in Chronic Myeloid Leukaemia
Status: UNKNOWN
Conditions: Chronic Myeloid Leukaemia
Interventions: DRUG: Imatinib|DRUG: nilotinib|DRUG: dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of αPD1-MSLN-CAR T Cells in MSLN-positive Advanced Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: αPD1-MSLN-CAR T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Laughter Therapy On Burnout And Guılt In Women
Status: NOT_YET_RECRUITING
Conditions: Laughter|Burnout
Interventions: BEHAVIORAL: laughter therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Therapy™ Cool Flex™ Irrigated Ablation System for Typical Atrial Flutter
Status: COMPLETED
Conditions: Typical Atrial Flutter
Interventions: DEVICE: Therapy™ Cool Flex™ Irrigated Ablation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Anlotinib Plus Chemotherapy as the First-line Treatment in Patients With Advanced NSCLC
Status: UNKNOWN
Conditions: NSCLC|Adenocarcinoma|Squamous Cell Carcinoma
Interventions: DRUG: Anlotinib combined with pemetrexed and carboplatin, phase I|DRUG: Anlotinib combined with paclitaxel and carboplatin, phase I|DRUG: Anlotinib combined with pemetrexed and carboplatin, phase II|DRUG: Anlotinib combined with paclitaxel and carboplatin, phase II
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxytocin Treatment of Alcohol Withdrawal
Status: COMPLETED
Conditions: Alcohol Withdrawal
Interventions: DRUG: intranasal oxytocin spray|OTHER: intranasal spray without oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Iodixanol vs. Iomeprol to Prevent Contrast-Induced Nephropathy After Coronary Intervention (CONTRAST)
Status: COMPLETED
Conditions: Renal Insufficiency, Chronic|Angioplasty, Transluminal, Percutaneous Coronary|Coronary Arteriosclerosis
Interventions: DRUG: Iodixanol 320|DRUG: Iomeprol 350
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Modified Specific Carbohydrate Diet on Bronchial Asthma Control in Children
Status: NOT_YET_RECRUITING
Conditions: Asthma in Children
Interventions: DIETARY_SUPPLEMENT: Modified Specific carbohydrate diet for 3 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Fatigue During Exercise in COPD-HF Overlap
Status: RECRUITING
Conditions: Pulmonary Disease, Chronic Obstructive|Heart Failure
Interventions: OTHER: Medical air|OTHER: Hyperoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Tai Chi on Cardiac Autonomic Function and Symptomatology in Women With Fibromyalgia: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: OTHER: Tai Chi Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bezlotoxumab Versus FMT for Multiple Recurrent CDI
Status: WITHDRAWN
Conditions: Clostridium Infections|Clostridioides Difficile|Enterocolitis, Pseudomembranous
Interventions: DRUG: Bezlotoxumab|PROCEDURE: Fecal Microbiota Transplantation (FMT)|DRUG: Vancomycin oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Premedication in Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Midazolam|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Remote Ischaemic Conditioning in Oncology Patients
Status: UNKNOWN
Conditions: Cardiotoxicity
Interventions: PROCEDURE: Remote Ischaemic Conditioning|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ridge Preservation With Platelet Rich Fibrin Augmented With Freeze Dried Bone Allograft
Status: COMPLETED
Conditions: Alveolar Ridge Preservation
Interventions: DEVICE: FDBA|DEVICE: PRF|PROCEDURE: Blood Clot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Olmesartan Medoxomil Versus Losartan in Patients With Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: olmesartan medoxomil|DRUG: losartan potassium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of Azithromycin in Idiopathic Purulent Oedematous Sinusitis in Adults
Status: RECRUITING
Conditions: Sinusitis, Chronic|Sinus Infection Chronic
Interventions: DRUG: Azithromycin Oral Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of PN401, Fluorouracil, Leucovorin and CPT-11 in Patients With Solid Tumors
Status: TERMINATED
Conditions: Solid Tumors
Interventions: DRUG: triacetyluridine|DRUG: fluorouracil|DRUG: leucovorin|DRUG: camptosar
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose Trial Investigating Safety, Tolerability and Pharmacokinetics of BDM-2 in Healthy Male Subjects.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BDM-2 in Bottle (50 mg - 3600 mg); oral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Infusion Pressure on the Outcomes of Phacoemulsification Surgery; the ENHANSE Study
Status: UNKNOWN
Conditions: Cataract
Interventions: DEVICE: Centurion Phacoemulsification System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Avatrombopag in the Treatment of Adult Immune Thrombocytopenia With Autoantibodies
Status: RECRUITING
Conditions: Immune Thrombocytopenia|Autoantibodies|Evan Syndrome|Connective Tissue Diseases
Interventions: DRUG: Avatrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Trial of Dexamethasone Use for Alleviation of Symptoms After Scleral Buckle Eye Surgery
Status: WITHDRAWN
Conditions: Retinal Detachment
Interventions: DRUG: Dexamethasone Sodium Phosphate Injection|DRUG: Saline Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioequivalence Study Between "DA-5215 Tab" and "DA-5215-R Tab"
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: DA-5215 Tab|DRUG: DA-5215-R Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in Blood Stage Malaria Infection After DVI of Cryopreserved P. Falciparum (NF54 Strain) Sporozoites
Status: COMPLETED
Conditions: Malaria,Falciparum|Parasitemia|Protozoan Infections|Parasitic Disease
Interventions: DRUG: Artemether-Lumefantrine 20 Mg-120 Mg Oral Tablet|BIOLOGICAL: PfSPZ-DVI Challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Initiation and Discontinuation of Short Term Zinc Supplementation on Plasma Zinc Concentration
Status: COMPLETED
Conditions: Zinc Deficiency
Interventions: DIETARY_SUPPLEMENT: zinc sulfate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy Plus Thalidomide in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: irinotecan hydrochloride|DRUG: thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Refinement and Adaption of Reinforcement Learning to Personalize Behavioral Messaging for Healthy Habits
Status: ENROLLING_BY_INVITATION
Conditions: Diabetes Mellitus, Type 2|Medication Adherence
Interventions: BEHAVIORAL: Reinforcement Learning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Self-Efficacy Levels of Nurses on Safe Blood and Blood Product Transfusion
Status: COMPLETED
Conditions: To Evaluate the Effect of Online Education on Nurses' Self-efficacy Regarding Blood Transfusion
Interventions: OTHER: online education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Food and Insulin Effect on QT/QTC Interval of ECG
Status: COMPLETED
Conditions: Effects of Different Meals on the QT/QTc Interval|Insulin and Oral Hypoglycemic [Antidiabetic] Drugs Causing Adverse Effects in Therapeutic Use|C-Peptide Effects on the QT/QTc Interval|Moxifloxacin ECG Profile in Fed and Fasted State|Japanese vs. Caucasian TQT Comparison
Interventions: DRUG: Moxifloxacin 400 mg fasted|OTHER: FDA breakfast|OTHER: Continental breakfast|DRUG: Moxifloxacin 400 mg fed|PROCEDURE: Insulin Clamp|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cisplatin/Etoposide and Concurrent Radiotherapy With or Without Celecoxib in Patients With Unresectable Locally Advanced Non-small Cell Lung Cancer (NSCLC)
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Activity Feedback Enabled by Smart Watches During In-patient Stroke Rehabilitation
Status: UNKNOWN
Conditions: Stroke
Interventions: BEHAVIORAL: Feedback against tailored target|BEHAVIORAL: No feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: B7-H3 Targeting CAR-T Cells Therapy for B7-H3 Positive Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: KT095 CAR-T injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Relative Bioavailability of Two Formulations of BIIB104 and Assess the Effect of Food on the Pharmacokinetics of BIIB104 Following Administration of a Single, Fixed, Oral Dose of BIIB104 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: BIIB104 Reference Formulation|DRUG: BIIB104 Test Formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tocotrienol Against the Progression of End Stage Liver Disease
Status: RECRUITING
Conditions: End Stage Liver Disease|NASH - Nonalcoholic Steatohepatitis|NAFLD - Nonalcoholic Fatty Liver Disease
Interventions: DRUG: Tocotrienol (TCT)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Evaluation of Safety and Efficacy of Using Imagine™ Computerized Radiofrequency System for Skin Tightening
Status: COMPLETED
Conditions: Skin Aging|Skin Wrinkling
Interventions: DEVICE: Endymion Imagine™ System for Skin Tightening
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study for Combination of Camrelizumab and SBRT in the First-line Treatment for R/M HNSCC
Status: UNKNOWN
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: OTHER: Camrelizumab and SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Utility of Bowel Ultrasound in Diagnosing Necrotizing Eneterocolitis in Congenital Heart Disease
Status: WITHDRAWN
Conditions: Enterocolitis, Necrotizing|Congenital Heart Disease
Interventions: DEVICE: Bowel Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Extension Trial of the Long Term Safety of BIBF 1120 in Patients With Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Nintedanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venous Sinus Stenting With the River Stent in IIH
Status: ACTIVE_NOT_RECRUITING
Conditions: Idiopathic Intracranial Hypertension
Interventions: DEVICE: Venous sinus stenting (Serenity River)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of SHR-1020 Combined With Albumin-bound Paclitaxel in the Second-line Treatment of Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: DRUG: SHR-1020+albumin-bound paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Efficacy of Etanercept in Patients Treated Over the Long-term in Real-world Clinical Practice, Using Data Collected by the British Society of Rheumatology Biologics Registry
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: etanercept|DRUG: non-biologic anti-rheumatic drugs
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Imaging Studies of Kidney Cancer Using 18F-VM4-037
Status: TERMINATED
Conditions: Carcinoma, Renal Cell|Kidney Neoplasms
Interventions: DRUG: 18F-VM4-037|PROCEDURE: PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pharmacokinetic (PK) Study of a Combination of Indinavir, Ritonavir, and Amprenavir
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Indinavir/Ritonavir/Fosamprenavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risperidone and Desipramine in Alcohol Use and Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Alcoholism|Dual Diagnosis
Interventions: DRUG: Risperidone + Desipramine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calcineurin Inhibitor (CNI)-Free Immunosuppressive Regimen in T1D Patients Receiving Islet Transplantation
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: CNI free immunosuppression
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biofeedback Retention in Individuals With AKA
Status: RECRUITING
Conditions: Amputation of Knee|Back Pain|Osteo Arthritis Knee
Interventions: DEVICE: Haptic Biofeedback from SageMotion Biofeedback System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 2 Study of VX-950, Pegasys® With and Without Copegus® in Hepatitis C
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Ribavirin|DRUG: Pegylated Interferon Alfa 2a|DRUG: Placebo|DRUG: Telaprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrative Couple Treatment for Pathological Gambling
Status: COMPLETED
Conditions: Pathological Gambling
Interventions: BEHAVIORAL: Integrative Couple Treatment for Pathological Gambling (ICT-PG)|BEHAVIORAL: Usual individual/group treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of DN101 and Taxotere in Patients With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: calcitriol + docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of IMC-11F8 in Participants With Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: BIOLOGICAL: IMC-11F8 (necitumumab)|DRUG: Oxaliplatin|DRUG: Folinic acid (FA)|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective, Multicenter, Observational Study of Apatinib Single or Combined Capecitabine for Treatment of Patients With Metastatic Her-2 Negative Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer Metastatic
Interventions: DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Safety and Drug Levels of HIB210 in Healthy Volunteers
Status: COMPLETED
Conditions: Immune System Diseases|Autoimmunity
Interventions: DRUG: HIB210|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endovascular vs Surgical Arteriovenous Fistula Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Dialysis Fistula Creation|Endo-vascular AVFs
Interventions: PROCEDURE: Surgical AVF|PROCEDURE: Endo-vascular AVF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Multi-virus Cytotoxic T-cells Following T-Cell Depleted Allogeneic HPCT for Prophylaxis Against EBV, ADV, and CMV
Status: COMPLETED
Conditions: Epstein-Barr Virus Infections|Adenovirus|Cytomegalovirus Infections
Interventions: BIOLOGICAL: Cytotoxic T Lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Lu-177-DOTATATE (Lutathera) in Combination With Olaparib in Inoperable Gastroenteropancreatico Neuroendocrine Tumors (GEP-NET)
Status: RECRUITING
Conditions: Gastroenteropancreatico Tumors|Neuroendocrine Tumors|Neuroendocrine Neoplasms
Interventions: DRUG: Lu-177-DOTATATE|DRUG: Olaparib|DIAGNOSTIC_TEST: Ga dotatate scanning|DIAGNOSTIC_TEST: FDG-PET scanning|DRUG: Amino Acid infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Multi-center Evaluation of E-Poly and Regenerex
Status: UNKNOWN
Conditions: Osteoarthritis of Hip|Traumatic Arthritis of Hip
Interventions: PROCEDURE: Total Hip Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study of ASP1585 in Chronic Kidney Disease Patients With Hyperphosphatemia Not on Dialysis
Status: COMPLETED
Conditions: Chronic Kidney Disease|Renal Insufficiency|Hyperphosphatemia
Interventions: DRUG: ASP1585|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fixation of Fracture Neck of Femur in Children
Status: NOT_YET_RECRUITING
Conditions: Fracture Neck of Femur
Interventions: PROCEDURE: Cannulated screws vs wagner's technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electrical Stimulation for the Treatment of Chronic Post-Stroke Shoulder Pain Using the Smartpatch System
Status: COMPLETED
Conditions: Post-stroke Shoulder Pain|Hemiplegic Shoulder Pain
Interventions: DEVICE: Smartpatch Peripheral Nerve Stimulation (PNS) System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NAT2 Genotyping in Re-challenge Protocol of INH Titration in Patients With Anti-TB Medications-induced Hepatitis
Status: UNKNOWN
Conditions: Hepatotoxicity
Interventions: DRUG: isoniazid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy Study Comparing 3 New Types of Coronary Stents
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Thrombosis
Interventions: DEVICE: Everolimus-eluting stent|DEVICE: Bare-metal stent|DEVICE: Biodegradable Polymer-DES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using mHealth to Promote Post-Menstrual Regulation Contraceptive Uptake and Continuation in Bangladesh
Status: COMPLETED
Conditions: Contraception|Post-abortion|Abortion
Interventions: BEHAVIORAL: Mhealth intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Fecal Microbiota Transplantation for Irritable Bowel Syndrome Associated Food Intolerance
Status: RECRUITING
Conditions: Irritable Bowel Syndrome|Fecal Microbiota Transplantation
Interventions: BIOLOGICAL: FMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Daptomycin Prophylaxis in Two-Stage Exchange Arthroplasty: A Prospective, Randomized, Double-Blinded Trial
Status: NOT_YET_RECRUITING
Conditions: Periprosthetic Joint Infection
Interventions: DRUG: Cefazolin with Daptomycin|DRUG: Cefazolin with vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Allogeneic Stem Cell Transplantation Following Chemotherapy in Patients With Hemoglobinopathies
Status: COMPLETED
Conditions: Hemoglobinopathies|Sickle Cell Disease|Thalassemia
Interventions: DRUG: Busulfex|DRUG: Fludarabine|DRUG: Alemtuzumab|PROCEDURE: Stem Cell Transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of Strategies to Increase Enrollment in Clinical Trials for Children With Cancer
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Childhood Germ Cell Tumor|Extragonadal Germ Cell Tumor|Leukemia|Liver Cancer|Lymphoma|Neuroblastoma|Ovarian Cancer|Psychosocial Effects of Cancer and Its Treatment|Sarcoma|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: PROCEDURE: psychosocial assessment and care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Thiamine vs. Placebo on VO2 in Critical Illness
Status: COMPLETED
Conditions: Critically Ill|Respiratory Failure
Interventions: DRUG: Thiamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Training for Trauma Resuscitation
Status: COMPLETED
Conditions: Virtual Reality
Interventions: OTHER: Teaching of trauma resuscitation by using virtual reality simulation|OTHER: Teaching of trauma resuscitation by using mannequin based simulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of the Analgesic Effects of Acupuncture and Modulated Electroanalgesia in Cold Induced Pain
Status: COMPLETED
Conditions: Cold Exposure
Interventions: DEVICE: Transcutaneous Electric Nerve Stimulation|DEVICE: Interferential Current|PROCEDURE: Manual Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Interferon-alpha Treatment of Chronic Cough in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis
Status: TERMINATED
Conditions: Pulmonary Disease, Chronic Obstructive|Pulmonary Fibrosis|Cough
Interventions: DRUG: interferon-alpha lozenges|DRUG: placebo lozenges
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gynecologic Endoscopic Surgery of Female Motion Sickness Patients
Status: COMPLETED
Conditions: Motion Sickness|Postoperative Nausea and Vomiting|Ibuprofen
Interventions: DRUG: Ibuprofen|DRUG: sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Hypertension Detection and Follow-up Program (HDFP)
Status: COMPLETED
Conditions: Cardiovascular Diseases|Heart Diseases|Hypertension|Vascular Diseases
Interventions: DRUG: diuretics|DRUG: antihypertensive agents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors|NSCLC|Bladder Cancer|HNSCC|Renal Cancer|Melanoma|Anal Cancer|Colorectal Cancer|Cholangiocarcinoma|Gastric Cancer|Hepatocellular Carcinoma|Merkel Cell Carcinoma|Cervical Cancer
Interventions: DRUG: Continue PD-1/PD-L1 Inhibitors treatment|OTHER: Discontinue PD-1/PD-L1-1 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Counseling for Prematurity Using a Multimedia Education Tool
Status: COMPLETED
Conditions: Premature Birth|Counseling|Decision Making|Prenatal Care|Infant, Premature|Resuscitation
Interventions: OTHER: Multimedia Information|OTHER: Printed Handout
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Safety And Efficacy Study Of Allogeneic CAR Gamma-Delta T Cells in Subjects With Relapsed/Refractory Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Solid Tumor
Interventions: BIOLOGICAL: HLA-G-CAR.BiTE allogeneic γδ T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Control in Breast Surgery: Analgesia, Opioid Consumption and Inflammatory Response Evaluation
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Anesthesia
Interventions: DRUG: Block with lidocaine for SAM and PEC I block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Single Nuclei Sequencing in Human Skeletal Muscle After Unloading
Status: ENROLLING_BY_INVITATION
Conditions: Unilateral Lower Limb Suspension
Interventions: OTHER: Unilateral lower limb suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Amphetamine Induced Adult Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Burns|Acute Lung Injury|Acute Respiratory Distress Syndrome|Methamphetamine Abuse
Interventions: OTHER: Difference in development of Acute Lung Injury in Amphetamine positive and negative patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Automated Locomotor Training in Patients With Acute Incomplete Spinal Cord Injury: A Multicenter Trial
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Locomotor training using a robotic device|DEVICE: Locomotor training using a robotic device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Japan Dose Regimen Study of AZD1656 in Japanese Type 2 Diabetes Mellitus Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: AZD1656|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Delirium: Brain Vulnerability and Recovery
Status: COMPLETED
Conditions: Delirium|Postoperative Complications
Interventions: DEVICE: EEG|DEVICE: fcDOT|DEVICE: fcMRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of IDP-122 Lotion When Applied Topically to Subjects With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: IDP-122 Vehicle Lotion|DRUG: IDP-122 Vehicle Cream|DRUG: IDP-122 Lotion|DRUG: Ultravate Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Effects of Gastrointestinal Surgery in T2DM
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: PROCEDURE: Duodenal jejunal bypass plus sleeve gastrectomy|DRUG: Best medical treatment (Metformin ; gliclazide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ixekizumab (LY2439821) in bDMARD-Naive Participants With Radiographic Axial Spondyloarthritis
Status: COMPLETED
Conditions: Spondyloarthritis
Interventions: DRUG: Ixekizumab|DRUG: Placebo|DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of AP0302 5% Versus a Vehicle Comparator
Status: COMPLETED
Conditions: Pain|Delayed Onset Muscle Soreness
Interventions: DRUG: S-Ibuprofen Topical Gel 5%|DRUG: Vehicle Topical Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Invivo Clinical Assessment of Dimethyl Sulfoxide in OT Primer Prior to Dental Adhesive
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Diseases
Interventions: OTHER: 3M Adper Single Bond2|OTHER: Filtek Z350 XT, 3 M ESPE, St Paul, MN, USA)|OTHER: 3m ESPE etch|OTHER: OT Primer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Efficacy and Safety of GSK3196165 in Inflammatory Hand Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: GSK3196165|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel Plus Lycopene in Castration Resistant, Chemotherapy-Naïve Prostate Cancer Patients
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate|Recurrent Prostate Cancer|Stage I Prostate Cancer|Stage IIA Prostate Cancer|Stage IIB Prostate Cancer|Stage III Prostate Cancer
Interventions: DRUG: Docetaxel|DIETARY_SUPPLEMENT: Lycopene
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examination of the Relationship Between Home Affordances With Development
Status: COMPLETED
Conditions: Preterm Birth
Interventions: BEHAVIORAL: Affordances in the Home Environment for Motor Development-Infant Scale|BEHAVIORAL: Peabody Developmental Motor Scales-2|BEHAVIORAL: Test Of Sensory Functions In Infants (Tsfı)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Circulating Non-coding RNA in Acute Ischemic Stroke With Endovascular Treatment (EVTRNA)
Status: RECRUITING
Conditions: Stroke, Acute|Stroke, Ischemic|Endovascular Treatment
Interventions: GENETIC: Sequencing of circRNA/lncRNA/miRNA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Analgesia and Physiotherapy in Children With Cerebral Palsy (ANTALKINECP)
Status: TERMINATED
Conditions: Cerebral Palsy
Interventions: DRUG: Ibuprofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nutrition, Health and Quality of Life: Development of New Formulations of Traditional Products of the "Made in Italy" Diet Optimized for Consumers With an Age Over 50 Years (MIAO 50)
Status: COMPLETED
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: fortified milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of SP TFL and Ho:YAG for RIRS Using 145 µm and 200 µm Fibers
Status: UNKNOWN
Conditions: Kidney Stone|Nephrolithiasis|Urolithiasis
Interventions: PROCEDURE: SP TFL RIRS with 145 mcm fiber|PROCEDURE: SP TFL RIRS with 200 mcm fiber|PROCEDURE: Ho:YAG RIRS with 200 mcm fiber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Emotional Effects of Methylphenidate and MDMA in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 3,4-Methylenedioxymethamphetamine|DRUG: Methylphenidate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pain Relief Following Arthroscopic Rotator Cuff Repair: Perioperative Pregabalin Administration Versus Interscalene Brachial Plexus Block
Status: UNKNOWN
Conditions: Pain
Interventions: DRUG: Pregabalin|PROCEDURE: ISBPB - interscalene brachial plexus block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Peginterferon Alfa-2a [PEGASYS] in Patients With Chronic Hepatitis B Who Are HBeAg Positive
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Adefovir|DRUG: peginterferon alfa-2a [PEGASYS]|DRUG: peginterferon alfa-2a [PEGASYS]|DRUG: peginterferon alfa-2a [PEGASYS]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Combination Therapy With Ectiecinib, Pemetrexed and Platinum in Patients With Metastatic Non-squamous Non-small Cell Lung Cancer With EGFR Mutations.
Status: RECRUITING
Conditions: Non-squamous Non-small Cell Lung Cancer
Interventions: DRUG: Icotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Urokinase for the Treatment of Diabetic Foot Syndrome and Critical Limb Ischemia
Status: TERMINATED
Conditions: Diabetic Foot|Critical Limb Ischemia
Interventions: DRUG: urokinase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Understand Efficacy of Colesevelam in Diarrhea Predominant IBS Patients With Bile Acid Malabsorption
Status: COMPLETED
Conditions: Chronic Diarrhea|Irritable Bowel Syndrome With Diarrhea|Bile Acid Malabsorption
Interventions: DRUG: Colesevelam|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Radiological, Clinical, Functional Outcomes Between Anatomically Aligned Total Knee Arthroplasty and Conventional Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Knee Arthropathy|Anatomically Aligned Total Knee Arthroplasty
Interventions: DEVICE: Total knee arthroplasty prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Equitable Smoking Relapse Prevention
Status: WITHDRAWN
Conditions: Tobacco Use Disorder|Tobacco Dependence
Interventions: OTHER: Quitbuddy|OTHER: Control|OTHER: SDoH Augmentation|OTHER: SDoH Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Fast Track Diagnosis of Skin Cancer by Advanced Imaging Technologies and Tumour Tapestripping
Status: COMPLETED
Conditions: Skin Cancer|Malignant Melanoma
Interventions: DIAGNOSTIC_TEST: Reflectance confocal microscopy (RCM), Photoacoustic imaging (PAI) and tape-strippng of RNA and lipids
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Transbronchial, Cryoprobe and VATS Biopsy For the Diagnosis of Interstitial Lung Disease (ILD)
Status: COMPLETED
Conditions: Interstitial Lung Disease
Interventions: PROCEDURE: Cryobiopsy biopsy|PROCEDURE: Transbronchial Biopsy|PROCEDURE: VATS biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy
Status: COMPLETED
Conditions: Anesthesia|General Anesthesia|Analgesics, Opioid|Postoperative Complications|Pathologic Processes|Physiologic Effects of Drugs|Narcotics|Analgesics|Sleep Disordered Breathing|Obstructive Sleep Apnea of Child|Tonsillectomy|Respiratory Depression|Dexmedetomidine|Ketamine|Lidocaine|Gabapentin|Pulse Oximetry
Interventions: DRUG: Acetaminophen, gabapentin|DRUG: Acetaminophen|DRUG: Ketamine , Lidocaine , Dexmedetomidine|DRUG: Fentanyl, Dexmedetomidine|DRUG: Dexamethasone , Ondansetron|DRUG: Sevoflurane|DRUG: Sevoflurane, Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION