pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study to Evaluate the Safety and Efficacy of TSR-042, Bevacizumab, and Niraparib in Participants With Recurrent Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Neoplasm
Interventions: DRUG: Dostarlimab|DRUG: Bevacizumab|DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety Study of Etomidate Versus Midazolam to Help Place a Breathing Tube Outside of the Hospital.
Status: COMPLETED
Conditions: Respiratory Failure
Interventions: DRUG: Etomidate (20mg) or Midazolam (7mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: SIESTA: Home Sleep Study With ApneaDx™ for the Diagnosis of Obstructive Sleep Apnea
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Portable Sleep Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Hormone Therapy and Chemotherapy in Treating Perimenopausal or Postmenopausal Women With Node-Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: epirubicin hydrochloride|DRUG: tamoxifen citrate|DRUG: toremifene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Feasibility of Injecting PMD-MSC Into the Penis to Treat the Symptoms of PD
Status: COMPLETED
Conditions: Peyronie's Disease
Interventions: BIOLOGICAL: Placental Matrix-Derived Mesenchymal Stem Cells (PMD-MSCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immobilization Without Reduction vs. Reduction Under General Anesthesia in Metaphyseal Fractures of the Distal Radius
Status: UNKNOWN
Conditions: Radius Fracture Distal
Interventions: PROCEDURE: In situ immobilization|PROCEDURE: Reduction under general anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalency Study of Valacyclovir Hydrochloride 1000 mg Under Fasting Conditions
Status: COMPLETED
Conditions: Herpes Zoster|Shingles|Genital Herpes
Interventions: DRUG: Valacyclovir Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Fluid Responsiveness With Pulse Variation Index and Systolic Blood Pressure Changes After Lung Recruitment Maneuver
Status: UNKNOWN
Conditions: Pleth Variability Index|Lung Recruitment Maneuver|Fluid Responsiveness
Interventions: DIAGNOSTIC_TEST: The research is terminated by calculating the percentage of PVI changes with SAB formed by LRM after fluid challenge.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Study of 5 mg and 10 mg Rosuvastatin
Status: UNKNOWN
Conditions: Dyslipidemia
Interventions: DRUG: Rosuvastatin 5 mg|DRUG: Rosuvastatin 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Do Rocker Bottom Shoes and Ankle-Foot Orthoses Reduce Pain and Improve Mobility for Ankle Osteoarthritis Patients
Status: UNKNOWN
Conditions: Ankle Osteoarthritis|Healthy Ankles
Interventions: DEVICE: Rocker bottom shoe|DEVICE: Ankle foot orthosis|DEVICE: Standard walking shoe
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel PET/CT Imaging Biomarkers of CB-839 in Combination With Panitumumab and Irinotecan in Patients With Metastatic and Refractory RAS Wildtype Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Metastatic Colorectal Cancer|RAS Wild Type Colorectal Cancer|Refractory Colorectal Cancer
Interventions: DRUG: Glutaminase Inhibitor CB-839|BIOLOGICAL: Panitumumab|DRUG: Irinotecan Hydrochloride (phase I only)|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DEVICE: Imaging with 11C-Glutamine PET/CT scans and 18F-FSPG PET/CT scans
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Restless Legs Syndrome in Hemodialysis Patients
Status: COMPLETED
Conditions: Restless Leg Syndrome
Interventions: OTHER: Vitamin C|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinical Study of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Moderate and Severe Crohn's Disease
Status: RECRUITING
Conditions: Crohn Disease
Interventions: BIOLOGICAL: Human Umbilical Cord Mesenchymal Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Health Effects of Coffee Consumption
Status: COMPLETED
Conditions: Overweight
Interventions: DIETARY_SUPPLEMENT: test coffee|DIETARY_SUPPLEMENT: control coffee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Influence Of GIP (Glucose-Dependent Insulinotropic Polypeptide) Infusion On Human Adipose Tissue: An In Vivo Study
Status: UNKNOWN
Conditions: Adipose Tissue
Interventions: OTHER: GIP (glucose dependent insulinotropic peptide) infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prophylactic Ethanol Lock Therapy (ELT) in Patients on Home Parenteral Nutrition
Status: TERMINATED
Conditions: Catheter-related Bloodstream Infection (CRBSI) Nos|Bloodstream Infection Due to Central Venous Catheter|Bloodstream Infection Due to Hickman Catheter
Interventions: DRUG: Ethanol|DRUG: Heparin Lock|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Immunotherapy With Non-Ablative Radiation in Previously Untreated Patients With Stage IV NSCLC
Status: RECRUITING
Conditions: NSCLC Stage IV
Interventions: DRUG: Pembrolizumab|RADIATION: Radiation|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of a Single Subcutaneous Dose of ALXN1210 in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ALXN1210 SC|DRUG: ALXN1210 IV|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Clinical Study to Evaluate the Effect of the Connected Inhaler System (CIS) on Adherence to Maintenance Therapy in Poorly Controlled Asthmatic Subjects
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: RELVAR/BREO|DRUG: Salbutamol|DEVICE: Smart phone app|DEVICE: HCP Dashboard|DEVICE: Sensors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Efficacy of ADVAGRAF (Tacrolimus Modified Release Formulation) in Kidney Transplant Patients Who Were Treated With PROGRAF
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: Prograf|DRUG: Advagraf
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Topical SB705498 on Healthy Volunteers
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: SB705498|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Potential Pharmacokinetic Interactions Between Phenytoin or Carbamazepine and Telaprevir
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Telaprevir|DRUG: Phenytoin|DRUG: Carbamazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Butylphthalide Soft Capsule for the Treatment of Vascular Dementia
Status: ACTIVE_NOT_RECRUITING
Conditions: Vascular Dementia
Interventions: DRUG: Butylphthalide soft capsule|DRUG: Placebo soft capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Mixed Exercise Regime and L-Carnitine Supplementation in HIV Patients on HAART
Status: WITHDRAWN
Conditions: HIV Infections|Hyperlipidemia|Exercise
Interventions: DIETARY_SUPPLEMENT: l-carnitine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Diagnosis and Intervention for Fetal Malposition in Active Labor and Its Impact on Mode of Delivery
Status: NOT_YET_RECRUITING
Conditions: Cesarean Delivery Affecting Fetus|Labor Dystocia|Labor Complication
Interventions: BEHAVIORAL: Maternal position change to side-lying lateral with peanut ball|BEHAVIORAL: Free maternal position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Guidance Device for Image Fusion and Needle Guidance in Lung, Liver or Kidney Biopsy
Status: WITHDRAWN
Conditions: Liver Biopsy|Lung Biopsy|Kidney Biopsy
Interventions: DEVICE: SCENERGY-guided Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Polyethylene-on-metal Bearing in Primary Total Hip Replacement
Status: WITHDRAWN
Conditions: Rheumatoid Arthritis|Osteoarthritis|Post-traumatic Arthritis|Collagen Disorders|Avascular Necrosis|Traumatic Femoral Fractures|Nonunion of Femoral Fractures|Congenital Hip Dysplasia|Slipped Capital Femoral Epiphysis
Interventions: DEVICE: Pinnacle Acetabular System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incorporating Avocados in Meals
Status: COMPLETED
Conditions: Satiety|Glycemic Index|Insulin|Gastrointestinal Peptides and Hormones
Interventions: DIETARY_SUPPLEMENT: Avocado supplement|DIETARY_SUPPLEMENT: Avocado included
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose:
Clinical trial: A Study Comparing Factor Level and Inhibitor Titer Testing Results Drawn From Central Venous Lines and Venipuncture
Status: TERMINATED
Conditions: Hemophilia A|Factor VIII Deficiency|Hemophilia|Hemophilia B|Factor IX Deficiency
Interventions: PROCEDURE: Peripheral Vein Blood draw
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lenalidomide Dose Escalation Combined With Rituximab/Fludarabine in Untreated CLL
Status: COMPLETED
Conditions: Leukemia, Lymphocytic, Chronic, B-Cell
Interventions: DRUG: Lenalidomide|DRUG: Fludarabine|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Rituximab and Bortezomib in Patients With Newly Diagnosed Acquired Hemophilia A
Status: UNKNOWN
Conditions: Acquired Hemophilia A
Interventions: DRUG: Bortezomib|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Taxi METERS: Measuring Effectiveness of Technology, Education, Referrals and Support
Status: ACTIVE_NOT_RECRUITING
Conditions: Improving Blood Pressure Control
Interventions: OTHER: CONTROL- Usual & Customary Health Fair Follow-up|OTHER: Health Fair + TECH [Text Messaging + Home Blood Pressure Monitoring]|OTHER: Heal th Fair + TECH [Text Messaging + Home Blood Pressure Monitoring] + Social Network Support (SNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Incident and Extent of Pulse Alteration During Local Anesthesia in Children
Status: UNKNOWN
Conditions: Tachycardia
Interventions: PROCEDURE: mandibular block with Epinephrine|PROCEDURE: C-CLAD-IL with Epinephrine|PROCEDURE: Infiltration with Epinephrine|PROCEDURE: Mandibular block without Epinephrine|PROCEDURE: C-CLAD-IL without Epinephrine|PROCEDURE: nfiltration without Epinephrine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Methylprednisolone in the Treatment of Patients With Signs of Severe Acute Respiratory Syndrome in Covid-19
Status: COMPLETED
Conditions: SARS-CoV Infection|Severe Acute Respiratory Syndrome (SARS) Pneumonia
Interventions: DRUG: Methylprednisolone Sodium Succinate|DRUG: Placebo solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Pharmacokinetics and Pharmacodynamics of THDB0206 Injection in Healthy Chinese Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: THDB0206 injection|DRUG: Humalog®|DRUG: BC222insulin lispro injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postpartum Deworming: Improving Breastfeeding and Optimizing Infant Growth
Status: COMPLETED
Conditions: Intestinal Diseases, Parasitic
Interventions: DRUG: Albendazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Study of Ragweed Allergy Immunotherapy Tablet in Subjects 50 Years of Age and Older (Study P06081)
Status: COMPLETED
Conditions: Rhinoconjunctivitis|Rhinitis|Conjunctivitis|Allergy
Interventions: DRUG: Placebo|BIOLOGICAL: SCH 39641|BIOLOGICAL: SCH 39641
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Survival TRial Using CytoKines in COVID-19 (STRUCK Trial)
Status: COMPLETED
Conditions: Covid19
Interventions: BIOLOGICAL: Ixekizumab|BIOLOGICAL: Aldesleukin|DRUG: Colchicine|DRUG: Standard of care (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Vitamin D Status and Vitamin D Receptor Polymorphisms in Patients With High Myopia and Primary Open-angle Glaucoma
Status: COMPLETED
Conditions: Vitamin D Deficiency|Primary Open-angle Glaucoma|High Myopia|Vitamin D Receptor Polymorphisms
Interventions: OTHER: Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by an enzyme-linked immuno-absorbent assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Transition Study From Flolan® to Remodulin® in Patients With Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension|Pulmonary Hypertension
Interventions: DRUG: treprostinil sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Duodenal-Jejunal Bypass(DJB) as a Potential Cure for Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: PROCEDURE: Duodenal-jejunal Bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Duowell® vs. Telmisartan Monotherapy in Mild Dyslipidemia Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension|Dyslipidemia
Interventions: DRUG: Duowell®|DRUG: Telmisartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impacts of Fruit on the Gut Health and Human Health
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiometabolic Health|Healthy Aging|Cognition
Interventions: OTHER: Fruit (2 cup eq)|OTHER: Fruit restriction (1/2 cup eq)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study Comparing the Efficacy of Intravenous Followed by Oral Itraconazole With Intravenous Caspofungin For Empiric Antifungal Therapy in Neutropenic Participants With Hematological Malignancy
Status: TERMINATED
Conditions: Hematologic Neoplasms
Interventions: DRUG: Itraconazole|DRUG: Caspofungin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind Study to Assess the Safety, Efficacy and Tolerability of Oral DFD-29 Capsules for the Treatment of Rosacea.
Status: COMPLETED
Conditions: Papulopustular Rosacea
Interventions: DRUG: DFD-29|DRUG: Doxycycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Drug Levels, Food and Relative Bioavailability of BMS-986365 in Healthy Adult Male Participants
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: BMS-986365|DRUG: Rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paired Emotion Reading Improves Emotion Regulation in Rural Children With ACE
Status: NOT_YET_RECRUITING
Conditions: Emotion Regulation|Adverse Childhood Experience
Interventions: BEHAVIORAL: the online Paired Emotion Reading Intervention (PERI)|BEHAVIORAL: the online Paired General Reading Intervention (PGRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trail of Neoadjuvant Endostar in Combination With Chemotherapy in Breast Cancer
Status: UNKNOWN
Conditions: Stage III Breast Cancer
Interventions: DRUG: docetaxel, epirubicin and cyclophosphamide|DRUG: docetaxel, epirubicin and cyclophosphamide plus endostar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity of a Split, Cell-Based, Inactivated, Trivalent Influenza Vaccine in Healthy Adult Subjects
Status: COMPLETED
Conditions: Influenza|Orthomyxoviruses|Myxovirus Infection
Interventions: BIOLOGICAL: Influenza virus vaccine - cell based (2007-2008 Formulation)|BIOLOGICAL: Influenza virus vaccine - cell-based (2007-2008 Formulation)|BIOLOGICAL: Influenza virus vaccine (2007-2008 Formulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Arimoclomol Prospective Study in Participants Diagnosed With Niemann-Pick Disease Type C
Status: ACTIVE_NOT_RECRUITING
Conditions: Niemann-Pick Disease, Type C
Interventions: DRUG: arimoclomol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characterizing Histiocytosis With 68Ga-FAPI PET/CT
Status: NOT_YET_RECRUITING
Conditions: Histiocytosis
Interventions: DIAGNOSTIC_TEST: 68Ga-FAPI|DIAGNOSTIC_TEST: 18F-FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: KN057 Multiple Dose Study in Moderately Severe to Severe Hemophilia
Status: RECRUITING
Conditions: Hemophilia
Interventions: BIOLOGICAL: KN057 doseⅠ|BIOLOGICAL: KN057 dose Ⅱ|BIOLOGICAL: KN057 dose Ⅲ
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Long-Term Safety of Symbicort in Asthmatic Children - SAPLING
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: budesonide/formoterol (Symbicort)|DRUG: budesonide (Pulmicort)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Electrical Stimulation in Patients With COVID19 Associated Pneumonia
Status: UNKNOWN
Conditions: COVID-19 Pneumonia
Interventions: OTHER: Neuromuscular Electrical Stimulation|OTHER: Physical Therapy Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Trial to Determine the Safety and Immunogenicity of Healthy Candidate MERS-CoV Vaccine (MERS002)
Status: COMPLETED
Conditions: Middle East Respiratory Syndrome Coronavirus
Interventions: BIOLOGICAL: ChAdOx1 MERS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Patient Comfort Using Green vs. Yellow Pan Retinal Photocoagulation
Status: COMPLETED
Conditions: Proliferative Diabetic Retinopathy - High Risk
Interventions: PROCEDURE: laser indirect ophthalmoscopy pan retinal photocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PGI2 Versus Nitroglycerine for Management of Pulmonary Hypertension After Valve Surgeries
Status: UNKNOWN
Conditions: Pulmonary Hypertension
Interventions: DRUG: Nitroglycerin|DRUG: PGI2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Time to Return of Bowel Function Following Perioperative Probiotics in Colorectal Cancer Surgery
Status: RECRUITING
Conditions: Colorectal Cancer|Ileus Postoperative|Flatus|Diet, Healthy
Interventions: DIETARY_SUPPLEMENT: Nestle Isocal|DIETARY_SUPPLEMENT: Nestle Boost Optimum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autism Adaptive Community-based Treatment to Improve Outcomes Using Navigators (ACTION) Network
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Engagement Intervention|BEHAVIORAL: Engagement + Coaching Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of the Combination of Vorinostat and Radiation Therapy for the Treatment of Patients With Brain Metastases
Status: COMPLETED
Conditions: Brain Metastases
Interventions: DRUG: Vorinostat|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation and Expansion Study of CPO107 for Patients With Advanced CD20-positive Non-Hodgkins Lymphoma
Status: SUSPENDED
Conditions: CD20 Positive Non Hodgkin Lymphoma
Interventions: DRUG: CPO107
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Verinurad on the Electric Activity of the Heart
Status: COMPLETED
Conditions: Healthy Volunteers (Intended Indication: Chronic Kidney Disease)
Interventions: DRUG: Verinurad|DRUG: Placebo|DRUG: Allopurinol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stellate Ganglion Block (SGB) For Women for Breast Cancer
Status: COMPLETED
Conditions: Hot Flushes|Hot Flashes
Interventions: DRUG: Bupivicaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Online, Compassion Intervention for Adults With Type 1 and Type 2 Diabetes Mellitus (T1DM; T2DM).
Status: COMPLETED
Conditions: Type 1 Diabetes|Type 2 Diabetes
Interventions: BEHAVIORAL: Four Week Self-Compassion Course
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Task-Specific Training in an Augmented Reality Context on Upper Limb Function and Activities in Children With Spastic Cerebral Palsy
Status: RECRUITING
Conditions: Cerebral Palsy, Spastic
Interventions: OTHER: INTERACT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Duration of Indwelling Urinary Catheter Following Pelvic Surgery
Status: COMPLETED
Conditions: Urinary Retention
Interventions: DRUG: Prazosin given 6 hours prior to catheter removal in the 24 hour group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation in Children With Stroke
Status: COMPLETED
Conditions: Hemiparesis|Neonatal Stroke|Ischemic Stroke|Hemorrhagic Stroke|Thrombotic Stroke
Interventions: DEVICE: Transcranial Magnetic Stimulation|DEVICE: Sham Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aggressive Smoking Cessation Trial (ASAP)
Status: RECRUITING
Conditions: Acute Coronary Syndrome|Cardiovascular Diseases
Interventions: COMBINATION_PRODUCT: Combination Therapy Arm (Varenicline and Nicotine E-Cigarettes Plus Counseling)|OTHER: Varenicline Plus Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: fMRI and Visceral Perception Upon Capsaicin Infusion
Status: COMPLETED
Conditions: Irritable Bowel Syndrome|Colonic Diseases, Functional|Dyspepsia|Gastrointestinal Diseases|Abdominal Pain|Visceral Pain
Interventions: OTHER: Capsaicin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: BHT-3009 Immunotherapy in Relapsing Remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: BHT-3009 0.5 mg|DRUG: BHT-3009 1.5 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Sucrosomial Iron on Insomnia in Non-dialysis Chronic Kidney Disease Patients With Iron Deficiency Anemia
Status: RECRUITING
Conditions: CKD|Sleep Disorder
Interventions: DIETARY_SUPPLEMENT: Sideral® Sucrosomial Iron|DIETARY_SUPPLEMENT: Iron chewable tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection
Status: RECRUITING
Conditions: Endodontic Disease|Root Canal Infection
Interventions: DEVICE: Waterlase Express™, BIOLASE®|OTHER: Sodium Hypochlorite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Benzalkonium Chloride Preserved and Preservative-free Latanoprost Eye Drops on Conjunctival Goblet Cells
Status: RECRUITING
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: Xalatan|DRUG: Monoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Maternal Music Exposure During Pregnancy Influences Neonatal Behaviour
Status: COMPLETED
Conditions: Normal Healthy Term Appropriate-for-date Newborn
Interventions: OTHER: "Garbh Sanskar" audio cassette (Times Music Inc., Mumbai, India)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Validation of Nutritional Supplements("Ketogenic Plus") Developed for Pancreaticobiliary Cancer Patients
Status: UNKNOWN
Conditions: Pancreaticobiliary Cancer
Interventions: DIETARY_SUPPLEMENT: Postoperative Nutritional Supplement|OTHER: Routine post-op care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Use of a Water Soluble Under the Tongue (Sublingual) CBD Tablet for Treating Pain Associated With Diabetic Peripheral Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathies
Interventions: DRUG: CBD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Celecoxib Versus Ibuprofen in the Treatment of Osteoarthritis of the Knee (Europe)
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Ibuprofen|DRUG: Placebo|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prognostic Factor Research of Sensory Profiles in Development of Central Sensitization
Status: COMPLETED
Conditions: Sensory Profiles|Central Sensitisation|Low Back Pain|Nociplastic Pain
Interventions: OTHER: In line with the Dutch guideline for non-specific low back pain, Standard usual care for non-specific low back pain was applied.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Oxytocin, Trauma Disclosure and Intrusions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immunogenicity, Safety and Protective Effect of Live Attenuated Varicella Vaccine and Study on Antibody Level and Etiology of Varicella Zoster Virus
Status: UNKNOWN
Conditions: Varicella
Interventions: BIOLOGICAL: Live attenuated varicella vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Open-label Investigation of the Safety and Effectiveness of DIABECELL® in Patients With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: DIABECELL (R)|DEVICE: DIABECELL (R)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sugammadex/Neostigmine and Liver Transplantation
Status: COMPLETED
Conditions: Postoperative Residual Curarization|Liver Transplantation
Interventions: DRUG: sugammadex|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comprehensive Cognitive Remediation as a Strategy to Prevent Cognitive Impairment Associated With Age and Disability With the REHACOP Program
Status: COMPLETED
Conditions: Aging
Interventions: BEHAVIORAL: Cognitive Remediation Program (REHACOP)|OTHER: Occupational Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Bioelectric Dressing for Post De-Roofing Treatment of HS
Status: ACTIVE_NOT_RECRUITING
Conditions: Hidradenitis Suppurativa
Interventions: DEVICE: Procellera Bioelectric Dressing|OTHER: Standard Gauze Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Food-based Solutions for Optimal Vitamin D Nutrition and Health
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: OTHER: Non-fortified foods|OTHER: Fortified foods
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Doxorubicin-GnRH Agonist Conjugate AEZS-108 in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Hormone-resistant Prostate Cancer|Recurrent Prostate Cancer|Stage IV Prostate Cancer
Interventions: OTHER: laboratory biomarker analysis|OTHER: questionnaire administration|DRUG: doxorubicin-GnRH agonist conjugate AEZS-108
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY2828360 in Patients With Osteoarthritic Knee Pain
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: LY2828360|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Adjunctive Pregnenolone in Post-Traumatic Stress Disorder (PTSD) and Depression in Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) Veterans
Status: WITHDRAWN
Conditions: Post-traumatic Stress Disorder|Major Depressive Disorder
Interventions: DRUG: pregnenolone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Radiation Therapy Plus Hormone Therapy Compared With Radiation Therapy Alone in Treating Patients With Stage II or Stage III Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: bicalutamide|DRUG: flutamide|DRUG: releasing hormone agonist therapy|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adaptation to Ozone in Individuals With Asthma/Exercise-induced Bronchoconstriction
Status: UNKNOWN
Conditions: Asthma|Asthma, Exercise-Induced|Exercise Induced Asthma|Exercise Induced Bronchospasm
Interventions: BEHAVIORAL: Exercise|OTHER: Ozone|OTHER: Filtere Air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Acute Effect of Isotonic Versus Isometric Exercise Versus Walking on Pain in Individuals With Plantar Fasciopathy
Status: COMPLETED
Conditions: Plantar Fasciopathy
Interventions: OTHER: Isometric exercise|OTHER: Isotonic exercise|OTHER: Walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Video as a Tool to Improve Insight in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: OTHER: Video self-observation|OTHER: Non Self video observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Integrated Cueing on Functional Transfers in Chronic Stroke Survivors
Status: COMPLETED
Conditions: Hemiplegia and/or Hemiparesis Following Stroke
Interventions: OTHER: Integrated Cueing Protocol|OTHER: Verbal Cueing Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of One Dose of Novartis' Meningococcal ACWY-CRM Vaccine and GlaxoSmithKline Biologicals' Meningococcal ACWY-TT Vaccine in Healthy Toddlers
Status: COMPLETED
Conditions: Meningococcal Disease
Interventions: BIOLOGICAL: MenACWY-CRM|BIOLOGICAL: MenACWY-TT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Diet, Exercise, Metabolism, and Obesity in Older Women
Status: COMPLETED
Conditions: Abdominal Obesity|Metabolic Syndrome
Interventions: BEHAVIORAL: Caloric Restriction|BEHAVIORAL: Caloric Restriction + Low-Intensity aerobic exercise|BEHAVIORAL: Caloric Restriction plus High-intensity aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ear Neurostimulation for Adolescents With Functional Abdominal Pain
Status: COMPLETED
Conditions: Functional Disorder of Intestine|Nausea Persistent
Interventions: DEVICE: Neurostimulator|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Pharmacokinetics, Tissue Distribution, Metabolism and Dosimetry of Two Prostate Cancer Imaging Agents
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: 123-I-MIP-1072|DRUG: 123-I-MIP-1095
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A German Study Evaluating the Efficacy and the Benefit of Integrated Personalized Diabetes Management (PDM) for Type 2 Diabetes Patients.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: Accu-Chek Smart Pix Software|DEVICE: Accu-Chek Smart Pix readout Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD0914
Status: COMPLETED
Conditions: Gonococcal (GC) Infection
Interventions: DRUG: Part A|DRUG: Part B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of CPETarm for Risk Stratification of Patients With CLTI
Status: NOT_YET_RECRUITING
Conditions: Chronic Limb-Threatening Ischemia|Surgery-Complications
Interventions: DIAGNOSTIC_TEST: CardioPulmonary Exercise Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mechanism of Mindfulness Intervention for Emotional Distress: the Role of Cognitive Flexibility
Status: NOT_YET_RECRUITING
Conditions: Emotional Distress
Interventions: BEHAVIORAL: Mindfulness Intervention for Emotional Distress(MIED)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and the Safety Study of RD94 in Patients With Endodontic Care
Status: COMPLETED
Conditions: Tooth Injury
Interventions: DEVICE: Application of Biodentine™ (RD94), dentin substitute
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Receptor Occupancy of LB-102 Using Positron Emission Tomography (PET) in Healthy Volunteers
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: LB-102
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: ASSET 2 Study: Long-Term Follow-up of a Randomised Control Trial
Status: COMPLETED
Conditions: Shoulder Dislocation
Interventions: PROCEDURE: Arthroscopic Washout Only|PROCEDURE: Arthroscopic Bankart Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Use of Alpha-Blockers to Treat Symptoms in Prostate Cancer Patients Undergoing Radiation Therapy
Status: UNKNOWN
Conditions: Urinary Problems|Prostate Cancer
Interventions: DRUG: Preventive administration of Rapaflo|DRUG: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of Treatment Response Using PET/CT Scanner - Non Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin
Interventions: PROCEDURE: PET Scan with [18F]Fluoro-2-deoxyglucose (FDG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Zofin to Treat Chronic Obstructive Pulmonary Disease (COPD)
Status: SUSPENDED
Conditions: COPD
Interventions: DRUG: Zofin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial to Evaluate the Optimal Timing of Surgical Antimicrobial Prophylaxis
Status: COMPLETED
Conditions: Surgical Site Infection
Interventions: PROCEDURE: Early administration of SAP (Cefuroxime (plus metronidazole in colorectal surgery)) in anesthetic room (75 to 30 minutes prior to skin incision)|PROCEDURE: Late administration of SAP (Cefuroxime (plus metronidazole in colorectal surgery)) in the operating theatre (within 30 minutes prior to skin incision)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Long-Term Nutritional Support in Patients With the Acquired Immunodeficiency Syndrome: Comparison of Liposyn III 2 Percent With Liposyn II 20 Percent
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Fat Emulsion 2%|DRUG: Fat Emulsion 20%
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of LY3471851 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3471851|DRUG: Placebo|DRUG: Levocetirizine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: A Multi-center Stepped Wedge Cluster Randomized Study
Status: NOT_YET_RECRUITING
Conditions: Acute, Perforated Appendicitis
Interventions: DRUG: Irrigation with PVI|PROCEDURE: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Injectable Platelet Rich Fibrin With Non Surgical Periodontal Therapy
Status: UNKNOWN
Conditions: CHRONIC PERIODONTITIS
Interventions: OTHER: Placebo gel|DRUG: Hyaluronic acid gel|BIOLOGICAL: Platelet rich fibrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Perianal Abscess Cavity Packing vs no Packing.
Status: COMPLETED
Conditions: Perianal Abscess|Ischiorectal Abscess
Interventions: PROCEDURE: No packing of perianal abscess cavity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Clostridium Difficile Vaccine 2-Dose Versus 3-Dose Study
Status: COMPLETED
Conditions: Clostridium Difficile Associated Disease
Interventions: BIOLOGICAL: Clostridium difficile|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TCM in the Treatment of Lung Adenocarcinoma
Status: UNKNOWN
Conditions: Lung Adenocarcinoma
Interventions: DRUG: Jing-yan-kang Granule|DRUG: PC chemotherapy and symptomatic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of PD-L1 Therapy Combined With Anti-VEGF Therapy in Unresectable or Metastatic Melanoma
Status: RECRUITING
Conditions: Clinical Stage III Cutaneous Melanoma AJCC v8|Stage IV Melanoma|Unresectable Stage III Cutaneous Melanoma|Unresectable Stage IV Cutaneous Melanoma
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Notes Adnexectomy for Benign Pathology Compared to Laparoscopic Excision
Status: COMPLETED
Conditions: Natural Orifice Endoscopic Surgery|Disease, Adnexal|Laparoscopic Surgery
Interventions: PROCEDURE: vNOTES adnexectomy|PROCEDURE: Laparoscopic adnexectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoantigen Vaccine Plus Locally Administered Ipilimumab and Systemic Nivolumab in Advanced Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: DRUG: Nivolumab|BIOLOGICAL: NeoVax plus Montanide|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Double-Masked Comparison of FID 123320 Ophthalmic Solution to Vehicle for the Reduction of Ocular Redness
Status: RECRUITING
Conditions: Ocular Redness
Interventions: DRUG: Apraclonidine Hydrochloride Ophthalmic Solution|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT