pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Medically-Graded Honey Supplementation Formula To Preterm Infants
Status: COMPLETED
Conditions: Prebiotics|Honey|Premature Infants|Intestinal Microbiota
Interventions: DIETARY_SUPPLEMENT: Medically-Graded Honey|OTHER: Premature Milk Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Prognosis of Surgical Intervention in Patients With Carotid Artery Stenosis
Status: RECRUITING
Conditions: Carotid Artery Stenting|Carotid Endarterectomy|Carotid Artery Plaque
Interventions: PROCEDURE: CEA or CAS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: LA Improves the Prognosis of Patients With ICVD
Status: NOT_YET_RECRUITING
Conditions: Ischemia|Cerebrovascular Ischemia|Cognitive Impairment
Interventions: DIETARY_SUPPLEMENT: Lactobacillus acidophilus|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Antibiotics in Children With Acute Sinusitis: Which Subgroups Benefit?
Status: COMPLETED
Conditions: Sinusitis|Respiratory Tract Infections
Interventions: DRUG: Amoxicillin-clavulanate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Absorption, Metabolism, and Elimination CC-90010 in Participants With Advanced Solid Tumors
Status: WITHDRAWN
Conditions: Advanced Solid Tumors
Interventions: DRUG: [14C]CC-90010|DRUG: CC-90010
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Nocebo Effects on Pressure Pain
Status: COMPLETED
Conditions: Pain|Hyperalgesia
Interventions: BEHAVIORAL: Closed-label nocebo conditioning|BEHAVIORAL: Closed-label counterconditioning|BEHAVIORAL: Open-label counterconditioning|BEHAVIORAL: Closed-label extinction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Proton Pump Inhibitors (PPIs)
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease (GERD)
Interventions: DRUG: IW-3718|DRUG: placebo|DRUG: Standard-dose PPIs QD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Retrospective Real-world Study of Abemaciclib in HR+ Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Neoplasms|Breast Diseases
Interventions: DRUG: Abemaciclib and Letrozole/Anastrozole|DRUG: Letrozole or Anastrozole|DRUG: Abemaciclib and Fulvestrant|DRUG: Fulvestrant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Foot Dystonia Treatment by Botulinum Toxin Injections in Parkinson Disease : Efficiency of Injections Made in Extrinsic Muscle (Flexor Digitorum Longus Muscle) Compared to Intrinsic Muscle (Flexor Digitorum Brevis or Quadratus Plantae Muscles)
Status: UNKNOWN
Conditions: Parkinson's Disease|Foot Dystonia
Interventions: DRUG: Botulinum Toxin: Xeomin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Randomized, Controlled Trial to Test Safety and Effectiveness of Unilateral Exablate MR-guided Focused Ultrasound Subthalamotomy in Patients With Early-Stage Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: PROCEDURE: Exablate MRgFUS subthalamotomy|DRUG: Best Medical Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study
Status: RECRUITING
Conditions: Cystic Fibrosis|Cystic Fibrosis Pulmonary Exacerbation
Interventions: DRUG: Beta-lactam antibiotic|DRUG: Aminoglycoside
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Lung-Protective Ventilation in Neurosurgery
Status: COMPLETED
Conditions: Ventilator-induced Lung Injury
Interventions: OTHER: lung-protective ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Polyphenol-rich Berry Juice on Blood Pressure in Hypertensive Subjects
Status: COMPLETED
Conditions: Pre-hypertension|Hypertension
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Mana-juice|DIETARY_SUPPLEMENT: Optijuice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adjustable Continence Therapy (ACT) for the Treatment of Female SUI
Status: RECRUITING
Conditions: Urinary Incontinence|Urinary Incontinence,Stress
Interventions: DEVICE: Adjustable Continence Therapy for Women (ACT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics,Safety and Tolerability of Y-2 Sublingual Tablet in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Y-2 Sublingual Tablet|DRUG: Y-2 Sublingual Tablet|DRUG: Y-2 Sublingual Tablet|DRUG: Y-2 Sublingual Tablet|DRUG: Y-2 Sublingual Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Transcranial Direct Current Stimulation (tDCS) to Improve Post-Stroke Aphasia
Status: COMPLETED
Conditions: Aphasia
Interventions: DEVICE: Transcranial Direct Current Stimulation|DEVICE: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of ST266 Ophthalmic Drops Compared to Placebo to Treat Allergic Conjunctivitis
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: BIOLOGICAL: ST266|DRUG: Saline (0.9% NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of tDCS on Postural Control of Children With DCD
Status: ACTIVE_NOT_RECRUITING
Conditions: Developmental Coordination Disorder
Interventions: DEVICE: Transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate Safety and Effectiveness of Oral Apremilast (CC-10004) in Patients With Moderate to Severe Plaque Psoriasis.
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Apremilast|DRUG: Placebo|OTHER: Topical or Phototherapy Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Value of the Combination Ultrasonography With Ti-RADS Score / Dual Tracer Scintigraphy MIBI-Tc99m/Iodine-123 in the Detection of Malignancy of Thyroid Nodules (≥15 mm) Classified Bethesda III or IV on Cytology
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignancy of Thyroid Nodules
Interventions: DRUG: MIBI-Tc99m/Iodine-123
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Risk Stratification for Venous Thromboembolism in Hospitalized Medical Patients
Status: COMPLETED
Conditions: Venous Thromboembolism|Venous Thromboses|Pulmonary Embolism|Deep Vein Thrombosis|Embolism and Thrombosis|Mobility Limitation|Hospital Acquired Condition
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Erector Spinae Plane Versus Quadratus Lumborum Block for Patient Undergoing Open Nephrectomy
Status: COMPLETED
Conditions: Renal Disease
Interventions: OTHER: control group|PROCEDURE: quadratus lumborum block type 3|PROCEDURE: erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Effects of Simultaneous Variety and Portion Size on Meal Intake of Women
Status: COMPLETED
Conditions: Eating Behavior
Interventions: OTHER: Simultaneous Variety|OTHER: Single-Food|OTHER: Small Portion|OTHER: Large Portion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sexual Dysfunction in Patients With Relapsing Remitting Multiple Sclerosis and Associated Comorbidities
Status: UNKNOWN
Conditions: Multiple Sclerosis|Sexual Dysfunction
Interventions: DIAGNOSTIC_TEST: MRI brain, visual evoked potential, Cerebrospinal Fluid, Sexual dysfunction measure, Depressive symptoms assessment and Multiple Sclerosis Quality of Life-54(MSQOL-54)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Itraconazole for Fungal Sensitive Chronic Rhinosinusitis With Nasal Polyps
Status: TERMINATED
Conditions: Chronic Rhinosinusitis
Interventions: DRUG: Itraconazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Levosimendan and Heart Failure
Status: WITHDRAWN
Conditions: Heart Failure|Hip Fracture
Interventions: DRUG: Levosimendan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Sequential Satraplatin & Erlotinib to Erlotinib in Unresectable Stage 3/4 Non-small-cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Erlotinib|DRUG: Satraplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of a Battery of Audiological Tests for the Precision Diagnosis of Age-related Hearing Loss
Status: RECRUITING
Conditions: Presbyacusis
Interventions: OTHER: Audiological and vestibular tests|OTHER: Blood sampling|OTHER: neurocognitive self-questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: RCT: STARR vs Biofeedback
Status: COMPLETED
Conditions: Gastric Outlet Obstruction|Rectocele|Intussusception|Anismus
Interventions: DEVICE: STARR|BEHAVIORAL: Biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lung and Diaphragm-Protective Ventilation by Means of Assessing Respiratory Work
Status: COMPLETED
Conditions: Diaphragm Injury|Lung Injury|Respiratory Insufficiency|Mechanical Ventilation Complication
Interventions: PROCEDURE: Lung- and Diaphragm-Protective Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Evaluation of 177Lu-DansyI-PSMA (LNC1011) in Patients With Metastatic Castration-Resistant Prostate Cancer
Status: RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer, mCRPC
Interventions: DRUG: 177Lu-Dansyl-PSMA radioligand therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tislelizumab and Radiotherapy for Recurrent Cervical Cancer
Status: UNKNOWN
Conditions: Recurrent Cervical Carcinoma|Metastatic Cervical Carcinoma|Persistent Cervical Carcinoma|Radiotherapy|Immunotherapy|Anti-programmed Cell Death Receptor 1|Immune Checkpoint Inhibitors|Tislelizumab|Objective Response Rate|Survival Outcomes
Interventions: COMBINATION_PRODUCT: Tislelizumab plus radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Double-blind Clinical Trial With L.Reuteri Supplementation in Children With Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DIETARY_SUPPLEMENT: L.Reuteri|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-center Study for Individual Treatment of Helicobacter Pylori Infection
Status: UNKNOWN
Conditions: Gastritis|Gastric Ulcer
Interventions: BIOLOGICAL: Antibiotic selection based on the antibiotic susceptibility testing|GENETIC: PPI selection based on the CYP2C19 gene polymorphism|DIETARY_SUPPLEMENT: Probiotics usage based on the 16SrRNA sequencing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Understanding Magnetic Resonance Imaging in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Multiple Sclerosis, Relapsing-Remitting|Clinically Isolated Syndrome
Interventions: OTHER: Understanding MRI in MS (website)|OTHER: Control website
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Impact of Nasal High-flow vs Venturi Mask Oxygen Therapy on Weaning Outcome: a Multicenter, Randomized, Controlled Trial
Status: COMPLETED
Conditions: Weaning Failure|Acute Respiratory Failure
Interventions: DEVICE: Optiflow (Fisher & Paykel Healthcare)|DEVICE: Venturi mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of an App-based Anxiety/Depression Program in a Population With Elevated Anxiety/Depression
Status: NOT_YET_RECRUITING
Conditions: Depression Anxiety Disorder
Interventions: BEHAVIORAL: Anxiety/Depression Program|OTHER: Waitlist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vitamin C and Atrial Fibrillation After Cardiac Surgery
Status: WITHDRAWN
Conditions: Atrial Fibrillation
Interventions: DRUG: Ascorbic Acid|OTHER: Identical Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of RANKL Inhibition on UV-induced Immunosuppression
Status: COMPLETED
Conditions: Ultraviolet Rays|Immunosuppression|Hypersensitivity, Delayed|Immune Tolerance/Drug Effects
Interventions: DRUG: Denosumab|RADIATION: UVB exposure|DRUG: Diphenylcyclopropenone|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prevention of Glucocorticoid-Induced Osteoporosis in Rheumatic Diseases: Alendronate Versus Alfacalcidol.
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Polymyalgia Rheumatica|Giant Cell Arteritis|Polymyositis|Wegener's Granulomatosis
Interventions: DRUG: Alendronate versus alfacalcidol (1-alpha OH vitamin D)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Analysis of Sensory Motor Training in Chronic Ankle Instability
Status: COMPLETED
Conditions: Recruitment
Interventions: OTHER: Group TSM ICT sneakers|OTHER: Group TSM ICT barefoot|OTHER: Group TSM health sneaker|OTHER: Group TSM health barefoot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Venetoclax and Selinexor in Treating Patients With Relapsed or Refractory High Risk Hematologic Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Diffuse Large B-cell Lymphoma|Acute Myeloid Leukemia|Non-Hodgkin's Lymphoma
Interventions: DRUG: Venetoclax|DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy of IN STI-9199 in Treating Symptomatic COVID-19 in Outpatient Adults and Adolescents
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: STI-9199|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II, Double-blinded, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Vitalliver in Patients With Decompensated Cirrhosis
Status: COMPLETED
Conditions: Hepatitis B|Hepatitis C|Liver Cirrhosis
Interventions: DRUG: Vitaliver|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Core Stability Exercise Versus Diaphragmatic Release on Respiratory Functions on Physical Therapists With Low Back Pain
Status: ENROLLING_BY_INVITATION
Conditions: Mechanical Low Back Pain|Respiratory Functions
Interventions: DEVICE: Core stabilization exercise using pressure biofeedback unit|PROCEDURE: Diaphragmatic release technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating A Planned Transition From Tacrolimus To Sirolimus In Kidney Transplant Recipients
Status: COMPLETED
Conditions: Graft Rejection|Kidney Transplant|Renal Allograft Recipients|Renal Transplant
Interventions: DRUG: Tacrolimus|DRUG: Sirolimus|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Providing Antibiotic Prescribing Feedback to Primary Care Physicians: The Ontario Program To Improve AntiMicrobial USE
Status: COMPLETED
Conditions: Antibiotic Prescribing Audit and Feedback
Interventions: OTHER: Antibiotic use feedback letter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Single Versus Double Hamstring Harvest for Anterior Cruciate Ligament Reconstruction
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Injury
Interventions: PROCEDURE: single-bundle, single-hamstring ACL reconstruction|PROCEDURE: single-bundle, double-hamstring ACL reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Investigate Benralizumab in Children With Eosinophilic Diseases
Status: NOT_YET_RECRUITING
Conditions: Eosinophilic Granulomatosis With Polyangiitis (EGPA)
Interventions: DRUG: Benralizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Preliminary Efficacy of BNT314 With or Without an Immune Checkpoint Inhibitor in Cancer Patients With Malignant Solid Tumors
Status: RECRUITING
Conditions: Advanced Malignant Solid Tumor
Interventions: BIOLOGICAL: BNT314|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: INtensity of OVarian Stimualtion and Euploid Embryos
Status: RECRUITING
Conditions: Fertility
Interventions: DRUG: Follitropin-delta (Rekovelle) 20 mcg/day from D1|DRUG: Follitropin-delta (Rekovelle) 15 mcg/day from D1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Inverse Ratio Ventilation During Induction of General Anesthesia on Safe Apnea Time in Obese Patients
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: Inspiratory-to-expiratory (I : E) ratio of 1:2|OTHER: Inspiratory-to-expiratory (I : E) ratio of 2:1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of Sintilimab or Placebo in Combination With Chemotherapy as Second-line Treatment for Patients With Stage IV Nonsquamous Non-small Cell Lung Cancer With Wild-type EGFR After Failure With Platinum-Containing Chemotherapy.
Status: UNKNOWN
Conditions: Nonsquamous Non-Small Cell Lung Cancer
Interventions: DRUG: Sintilimab|DRUG: Docetaxel|DRUG: Pemetrexed|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LSA4 Protocol for the Treatment of Advanced Pediatric and Adolescent Non-Hodgkins Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: LSA4, Cyclophosphamide, Methotrexate, Daunomycin, L-asparaginase, BCNU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carotid Endarterectomy vs. Repeated Carotid Angioplasty and Stenting for In-Stent Restenosis
Status: RECRUITING
Conditions: In-Stent Carotid Artery Restenosis
Interventions: PROCEDURE: Carotid endarterectomy with stent removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prognostic Value of Hemodynamic Disturbances in Rhegmatogenous Retinal Detachment (CRADO-RED)
Status: TERMINATED
Conditions: Retinal Detachment
Interventions: DEVICE: color Doppler ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Trial of Recombinant COVID-19 Vaccine (Sf9 Cells) in Children and Adolescents
Status: NOT_YET_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: Recombinant COVID-19 vaccine (Sf9 cells)|OTHER: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Development of a Biomarker of Efficacy of Vedolizumab (EnTyvio®) in Patients With ulcErative ColiTis (DETECT)
Status: TERMINATED
Conditions: ULCERATIVE COLITIS
Interventions: DRUG: VEDOLIZUMAB|DRUG: ADALIMUMAB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coping Peer Intervention for Adherence
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Coping Peer Support|BEHAVIORAL: Doctor Asthma Messages|BEHAVIORAL: Coping Peer Asthma Messages|BEHAVIORAL: Asthma Supervision|BEHAVIORAL: Music Tracks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Single Ascending Dose Study Investigating the Safety, Pharmacokinetics and Pharmacodynamics of RO6836191 in Healthy Male Volunteers.
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: OTHER: LS followed by NS diet condition|OTHER: NS followed by LS diet condition|DRUG: Placebo|DRUG: Placebo|DRUG: RO6836191|DRUG: RO6836191|DRUG: RO6836191
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Relevance of Typing HLA-DR7-DQ2
Status: COMPLETED
Conditions: Celiac Disease Patients Following Recommendations of ESPGHAN|HLA-DQ2 Typing Include HLA-DR7-DQ2 Haplotypes
Interventions: OTHER: There is not any intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Chemotherapy in Treating Patients With Stage III or Stage IV Malignant Peripheral Nerve Sheath Tumors
Status: COMPLETED
Conditions: Neurofibromatosis Type 1|Sarcoma
Interventions: BIOLOGICAL: filgrastim|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methylphenidate in Childhood Apraxia of Speech
Status: RECRUITING
Conditions: Childhood Apraxia of Speech
Interventions: DRUG: Methylphenidate Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Verification of the Safety of Early Discharge in Patients After Acute ST-segment Myocardial Infarction
Status: COMPLETED
Conditions: Coronary Artery Disease|Acute Myocardial Infarction With ST-segment Elevation|Primary Percutaneous Coronary Intervention|Early Discharge
Interventions: OTHER: Early discharge|OTHER: Standard discharge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: ARISCAT and LAS VEGUS Risk Scores for Predicting Postoperative Pulmonary Complications After Cardiac Surgery
Status: COMPLETED
Conditions: Pulmonary Complication|Postoperative Complications|Postoperative Pulmonary Complications
Interventions: DIAGNOSTIC_TEST: Detection/screening
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Long-Term Antibody Persistence at 1, 3 and 5 Years After a Fourth Dose of GSK Biologicals' Hib-MenCY-TT Vaccine Compared to ActHIB
Status: COMPLETED
Conditions: Neisseria Meningitidis|Haemophilus Influenzae Type b
Interventions: BIOLOGICAL: MenHibrix (Hib-MenCY-TT)|BIOLOGICAL: Hib conjugate vaccine (ActHIB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial to Evaluate the Efficacy and Safety of Faropenem Medoxomil In the Treatment of Chronic Bronchitis
Status: TERMINATED
Conditions: Chronic Bronchitis
Interventions: DRUG: Faropenem medoxomil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ARO-DUX4 in Adult Patients With Facioscapulohumeral Muscular Dystrophy Type 1
Status: RECRUITING
Conditions: Facio-Scapulo-Humeral Dystrophy
Interventions: DRUG: ARO-DUX4 for Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Colchicine in Non-Diabetic Adults With Metabolic Syndrome
Status: COMPLETED
Conditions: Obesity|Metabolic Disease
Interventions: DRUG: Colchicine 0.6Mg Cap|DRUG: Placebo capsules given|DRUG: Colchicine 0.6Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 1815368 in the Blood
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1815368|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Use of Norepinephrine in Septic Shock Resuscitation
Status: COMPLETED
Conditions: Septic Shock|Severe Sepsis
Interventions: DRUG: Early norepinephrine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bilateral Brain Stimulation in Trauma Therapy
Status: COMPLETED
Conditions: Intervention Study|Handling (Psychology)
Interventions: BEHAVIORAL: EMDR standard protocol|BEHAVIORAL: protocol without brain stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Trial Comparing the Incidence of Hypophosphatemia in Relation to Treatment With Iron Isomaltoside and Ferric Carboxymaltose in Subjects With Iron Deficiency Anaemia Due to Inflammatory Bowel Disease
Status: COMPLETED
Conditions: IBD
Interventions: DRUG: Iron Isomaltoside|DRUG: Ferric Carboxymaltose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autogenous Demineralized Dentin Block Graft Versus Particulate Deproteinized Bovine Bone Graft for Alveolar Ridge Preservation
Status: UNKNOWN
Conditions: Alveolar Bone Loss
Interventions: PROCEDURE: Alveolar ridge preservation using autogenous demineralized dentin block graft|PROCEDURE: Alveolar ridge preservation using particulate deproteinized bovine bone graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Canabrava/s Pupil Expansion Device in Cataract Surgery With Small Pupils: The First 30 Cases
Status: COMPLETED
Conditions: Small Pupil|Cataract
Interventions: DEVICE: Cana's Ring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of a Loop Stretchable Dental Floss
Status: NOT_YET_RECRUITING
Conditions: Gingivitis|Supragingival Plaque
Interventions: DEVICE: Brushing and Flossing of teeth|OTHER: Brushing Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Prevention of Female Cancers by Optimization of Selenium Levels in the Organism.
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Neoplasms
Interventions: DIETARY_SUPPLEMENT: Selenium supplementation or placebo treatment|OTHER: Diet modification|OTHER: Selenium supplementation or placebo treatment and diet modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Prospective Clinical Trial Evaluating Metronomic Chemotherapy in Patients With High-grade, Operable, Non-metastatic Osteosarcoma of the Extremity
Status: UNKNOWN
Conditions: High Grade Osteosarcoma
Interventions: DRUG: continuous oral cyclophosphamide and methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of Booster Immunization of ZF2001 After Inoculation With Two Doses of BBIBP-CorV
Status: UNKNOWN
Conditions: COVID-19
Interventions: BIOLOGICAL: Recombinant novel coronavirus vaccine (CHO cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Randomized Controlled Trial of a Risk Reframing Tool to Change Mothers' Parenting Associated With Children's Risky Play
Status: COMPLETED
Conditions: Risk Assessment|Parenting
Interventions: BEHAVIORAL: RR Digital Tool|BEHAVIORAL: RR In-Person Workshop|BEHAVIORAL: Position Statement on Active Outdoor Play
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing Efficacy and Safety of TJO-083 in Dry Eye Disease Patients
Status: UNKNOWN
Conditions: Dry Eye Syndromes
Interventions: DRUG: TJO-083|OTHER: Placebo (vehicle)|DRUG: Diquafosol ophthalmic sodium solution 3%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers in Tumor Tissue Samples From Young Patients With Very Low Risk Wilms Tumors
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: GENETIC: DNA methylation analysis|GENETIC: gene expression analysis|GENETIC: loss of heterozygosity analysis|GENETIC: microarray analysis|GENETIC: mutation analysis|GENETIC: polymerase chain reaction|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sintilimab With P-GEMOX Versus the P-GEMOX in the Teatment of Advanced-stage Extranodal Natural Killer/T Cell Lymphoma
Status: RECRUITING
Conditions: Natural Killer/T-Cell Lymphoma, Nasal and Nasal-Type
Interventions: DRUG: Sintilimab with P-GEMOX Regimen|DRUG: P-GEMOX Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of IMAB362 in Combination With the EOX Regimen for CLDN18.2-positive Gastric Cancer
Status: COMPLETED
Conditions: CLDN18.2-positive Adenocarcinoma of the Gastroesophageal Junction|CLDN18.2-positive Adenocarcinoma of Esophagus|CLDN18.2-positive Gastric Adenocarcinoma
Interventions: DRUG: epirubicin|DRUG: oxaliplatin|DRUG: capecitabine|DRUG: zolbetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Bulking Agents for the Treatment of Stress Urinary Incontinence in Females
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: Bulkamid|DEVICE: Contigen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Equivalence of Two Products Containing Metronidazole Benzoate
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Metronidazole benzoate oral granules|DRUG: Flagyl 400 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Advanced Breast Cancer|Metastatic Breast Cancer|Hormone-receptor-positive Breast Cancer|Hormone Receptor Positive Breast Carcinoma|Hormone Receptor Positive Malignant Neoplasm of Breast|HER2-negative Breast Cancer|Hormone Receptor Positive HER-2 Negative Breast Cancer|Non-small Cell Lung Cancer
Interventions: DRUG: BGB-43395|DRUG: Fulvestrant|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Learn About the Study Medicine Called Maplirpacept (PF-07901801), Alone and When Used in Combination With Other Medicines to Treat Participants With Advanced Hematological Malignancies, Including Lymphoma, Leukemia and Multiple Myeloma
Status: TERMINATED
Conditions: Lymphoma|Multiple Myeloma|Acute Myeloid Leukemia|Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Maplirpacept (PF-07901801)|DRUG: Azacitidine|DRUG: Venetoclax|DRUG: Carfilzomib|DRUG: Dexamethasone|DRUG: Anti-CD20 Targeting agent|DRUG: Isatuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Osteoporosis Using Denosumab
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal|Osteoporosis|Osteoporotic Fractures
Interventions: DRUG: denosumab|DRUG: Placebo|DIETARY_SUPPLEMENT: Calcium and Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: L-glutamine Supplementation to Alleviate Symptoms of Taxane-Induced Neuropathy in Patients With Breast Cancer
Status: WITHDRAWN
Conditions: Peripheral Neuropathy
Interventions: DIETARY_SUPPLEMENT: L-glutamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Uric Acid Lowering Trial in Youth Onset T2D
Status: RECRUITING
Conditions: Diabetic Kidney Disease|Hyperuricemia|Diabetes|Diabetes Mellitus, Type 2|Type2 Diabetes|Type 2 Diabetes Mellitus|Diabetic Nephropathies|Diabetes Complications
Interventions: DRUG: Pegloticase 8 MG/ML [Krystexxa]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Intravenous Iron Based Protocol for Preoperative Anaemia in Hip and Knee Surgery - An Observational Study
Status: UNKNOWN
Conditions: Anemia|Arthroplasty, Replacement, Hip|Arthroplasty, Replacement, Knee
Interventions: DRUG: Iron-III Isomaltoside 1000|OTHER: Standard Care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preoperative Rapid Pou Ultrasound Assessment in Critically Ill Patients Undergoing Emergency Surgery
Status: UNKNOWN
Conditions: Emergency Surgery
Interventions: DEVICE: POU protocol ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: INfluenza VaccInation To Mitigate typE 1 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1
Interventions: BIOLOGICAL: Vaxigrip Tetra Sanofi Pasteur Europe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Smartphone-Based Approach to Improved Breast-Feeding Rates And Self-Efficacy
Status: COMPLETED
Conditions: Breastfeeding
Interventions: OTHER: "Breastfeeding at AU" Apple-Based Smartphone Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Post-marketing Study to Evaluate the Effect of Mirabegron on the Plasma Concentration of Tolterodine
Status: COMPLETED
Conditions: Pharmacokinetics of Mirabegron and Tolterodine|Healthy
Interventions: DRUG: tolterodine|DRUG: mirabegron
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Contrast-Enhanced Mammography for Breast Cancer Staging in Patients Referred for a Second Opinion
Status: COMPLETED
Conditions: Breast Carcinoma|Invasive Breast Carcinoma
Interventions: PROCEDURE: Contrast-Enhanced Mammography|PROCEDURE: Digital Tomosynthesis Mammography|OTHER: Electronic Health Record Review|DRUG: Iodinated Contrast Agent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Lenalidomide in Treating Patients With High-Risk Chronic Lymphocytic Leukemia
Status: WITHDRAWN
Conditions: Chronic Lymphocytic Leukemia|Stage III Chronic Lymphocytic Leukemia|Stage IV Chronic Lymphocytic Leukemia
Interventions: OTHER: Diagnostic Laboratory Biomarker Analysis|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Functional Walking Outcomes of Two Settings of a Commercially Available AFO in Adult Stroke Patients
Status: COMPLETED
Conditions: Walking Aided by a Leg Brace in Stroke Subjects
Interventions: DEVICE: ADR™ brace resistance|DEVICE: Conventional brace resistance (using hard stops)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: ABemaciclib, ET ± paclItaxel in aGgressive HR+/HER2- MBC trIaL
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer Metastatic
Interventions: DRUG: Abemaciclib|DRUG: Paclitaxel|DRUG: Letrozole|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Curcumin and Vascular and Cognitive Function in Patients With Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Cognitive Decline
Interventions: DRUG: Curcumin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Toward Self-management in ILD
Status: COMPLETED
Conditions: Interstitial Lung Disease|Idiopathic Pulmonary Fibrosis|Connective Tissue Related ILD|Chronic Hypersensitivity Pneumonitis|Fibrotic Lung Disease
Interventions: BEHAVIORAL: Focus groups|BEHAVIORAL: Semi-structured interviews
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Anti-PD-1 Antibody Treatment With Cemiplimab and Radiotherapy in Early-stage Classical Hodgkin Lymphoma
Status: WITHDRAWN
Conditions: Hodgkin Lymphoma
Interventions: DRUG: Cemiplimab|RADIATION: Involved-site radiotherapy (IS-RT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Infectious Diseases Experts as Part of the Antibiotic Stewardship Team in Primary Care
Status: RECRUITING
Conditions: Infectious Disease
Interventions: BEHAVIORAL: Advanced AMS program|BEHAVIORAL: Standard AMS program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Antidepressant Controlled Trial for Negative Symptoms in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Citalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Computer-aided Optical Diagnosis (CAD) in Predicting Histology of Diminutive Rectosigmoid Polyps: a Multicenter Prospective Trial (ABC Study).
Status: COMPLETED
Conditions: Colonic Adenomatous Polyp
Interventions: DIAGNOSTIC_TEST: Polyp carachterization by combing endoscopist evaluation and Ai output
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation
Status: COMPLETED
Conditions: Liver Failure|End Stage Liver Disease|Biliary Tract Diseases
Interventions: PROCEDURE: Dual hypothermic oxygenated perfusion|DEVICE: Liver Assist®|PROCEDURE: Perfusion fluid|DRUG: Glutathione
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of a Self-Retaining Pannus Retractor in Obese Patients Undergoing Cesarean Section
Status: TERMINATED
Conditions: Obese Patients Undergoing Cesarean Section
Interventions: DEVICE: Traxi Pannus Retractor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pembrolizumab and ADG106 in Advanced Solid Cancers and Triple Negative Breast Cancer
Status: RECRUITING
Conditions: Advanced Solid Tumor|Triple Negative Breast Cancer
Interventions: DRUG: Pembrolizumab & ADG106 (Phase Ib)|DRUG: Pembrolizumab & ADG106 (Phase II)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MEAL TIMING Study: Effect of Time-Restricted Feeding on 24-hour Glycemic Control, Blood Pressure, and Cardiovascular Disease Risk Factors in Adults With Prediabetes
Status: RECRUITING
Conditions: PreDiabetes
Interventions: BEHAVIORAL: Early TRE|BEHAVIORAL: Mid-day TRE|BEHAVIORAL: Control Schedule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Munich Transcatheter Mitral Valve Safety and Effectiveness
Status: NOT_YET_RECRUITING
Conditions: Mitral Regurgitation|Mitral Valve Disease
Interventions: DEVICE: MUNICH TRANSCATHETER MITRAL VALVE REPLACEMENT SYSTEM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Relationship Between Obstructive Sleep Apnea and Alzheimer's Disease: Evidence and Effectiveness
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea of Adult|Mild Cognitive Impairment
Interventions: PROCEDURE: sleep surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Potentiation of Chemotherapy in Brain Tumors by Zinc
Status: UNKNOWN
Conditions: Newly Diagnosed Glioblastoma Who Underwent at Least Partial Resection of the Tumor Surgically
Interventions: DIETARY_SUPPLEMENT: zinc and ascorbate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Food on Oxycodone Pharmacokinetics in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxycodone|DRUG: Oxycodone|DRUG: Oxycodone|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Paclitaxel-Coated Balloon for the Treatment of AVF
Status: UNKNOWN
Conditions: Arteriovenous Fistula
Interventions: DEVICE: Paclitaxel-Coated Percutaneous Transluminal Angioplasty (PTA) Balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT