pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Decitabine, Venetoclax and Blinatumomab for Maintenance Following HSCT in Patients With Ph-Negative B-ALL
Status: NOT_YET_RECRUITING
Conditions: B-cell Acute Lymphoblastic Leukemia
Interventions: DRUG: Decitabine, venetoclax and blinatumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of WGI-0301 for Advanced HCC
Status: NOT_YET_RECRUITING
Conditions: Advanced Hepatocellular Carcinoma (HCC)
Interventions: DRUG: WGI-0301 at MTD/RP2D dose IV infusion, QW|DRUG: WGI-0301 at MTD/RP2D -1 dose IV infusion, QW|DRUG: Sorafenib 400 mg PO, BID continuously|DRUG: Sorafenib 400 mg PO, BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of VNS on RT-induced Inflammation and Prognosis of Patients With NSCLC
Status: UNKNOWN
Conditions: Lung Cancer, Non-small Cell
Interventions: DEVICE: Transcutaneous vagus nerve stimulation|DEVICE: Sham|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Alglucosidase Alfa Produced at the 4000 L Scale for Pompe Disease
Status: TERMINATED
Conditions: Pompe Disease
Interventions: DRUG: Alglucosidase alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Effect of Heart Rate Reduction With Ivabradine on Vascular Elastic Properties and Endothelial Function in Patients With Stable Coronary Heart Disease
Status: UNKNOWN
Conditions: Coronary Artery Disease|Coronary Arteriosclerosis
Interventions: DRUG: Ivabradine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Natalizumab as an Efficacy Switch in Participants With Relapsing Multiple Sclerosis After Failure on Other Therapies
Status: TERMINATED
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: natalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypothermia in Acute Ischemic Stroke - Surface Versus Endovascular Cooling (HAIS-SE)
Status: UNKNOWN
Conditions: Ischemic Stroke|Thrombolysis|Hypothermia
Interventions: DEVICE: ZOLL Thermogard XP|DEVICE: BARD/Medivance Arctic Sun 5000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AZD4547 & Anastrozole or Letrozole (NSAIs) in ER+ Breast Cancer Patients Who Have Progressed on NSAIs (RADICAL)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: AZD4547 / anastrozole or letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab, Temozolomide, and External Beam Radiation Therapy as First-Line Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: BIOLOGICAL: bevacizumab|DRUG: temozolomide|RADIATION: external beam radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atomoxetine to Treat Korean Children and Adolescents With Attention-Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Atomoxetine Hydrochloride|DRUG: Atomoxetine hydrochloride|DRUG: Atomoxetine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief Internet-Based Acceptance and Commitment Therapy Intervention for Parents in the Postpartum
Status: COMPLETED
Conditions: Postpartum Depression
Interventions: DIAGNOSTIC_TEST: Baseline Assessment|BEHAVIORAL: Brief Online ACT Intervention|DIAGNOSTIC_TEST: Post-Intervention Assessment (i.e. between 4-6 weeks after baseline assessment)|DIAGNOSTIC_TEST: Follow-up Assessment (i.e. between 8-12 weeks after baseline assessment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Cross-sectional Partnership to Improve Prevention
Status: RECRUITING
Conditions: Colorectal Cancer|Prevention
Interventions: OTHER: On-site Fecal Immunochemical Test (FIT) Kit Distribution|OTHER: Onsite with social media advertising Fecal Immunochemical Test (FIT) Kit Distribution
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Use of the Guardian™ Connect System With Smart Connected Devices
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Guardian™ Connect system, InPen™ Basal smart cap, smart insulin pens, and InPen™ Diabetes Management app
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy, Immunogenicity and Safety of Inactivated Vaccine (Coronavac) Against SARS-COV2 in Children and Adolescents
Status: UNKNOWN
Conditions: COVID-19
Interventions: BIOLOGICAL: Inactivated Coronavac/Butantan vaccine|BIOLOGICAL: BNT162b2 (Pfizer)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: a Risk Assessment and Management Program Using Telecare Consultation Among Patients With Diabetes Mellitus
Status: RECRUITING
Conditions: Diabetes Mellitus
Interventions: PROCEDURE: telecare consultation|PROCEDURE: Usual face to face consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Open-label Safety and Efficacy of SPN-812 (Viloxazine Extended-release Capsule) in Adults With ADHD and Mood Symptoms
Status: RECRUITING
Conditions: Attention-Deficit/Hyperactivity Disorder
Interventions: DRUG: SPN-812
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care Treatment
Status: RECRUITING
Conditions: Homocystinuria
Interventions: DRUG: Pegtibatinase|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Nigella Sativa Oil on Pain Intensity and Physical Functions in Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: Nigella sativa oil|BIOLOGICAL: Naproxen and lidocaine gel|BIOLOGICAL: Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of the Efficacy of Fecal Microbiota Transplantation(FMT) in the Treatment of Schizophrenia
Status: NOT_YET_RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: Fecal microbiota transplantation(FMT)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility of Percutaneous Dilatational Tracheostomy in Patients With Severe COVID-19 Supported by ECMO
Status: COMPLETED
Conditions: COVID-19 Pneumonia|Extracorporeal Membrane Oxygenation Complication|Tracheostomy Complication|Respiratory Failure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Early Compared With Delayed Hormone Therapy in Treating Patients With Nonmetastatic Prostate Cancer
Status: COMPLETED
Conditions: Neoplasm, Prostate
Interventions: PROCEDURE: Immediate Orchiectomy or depot LHRH|PROCEDURE: Delayed Orchiectomy or depot LHRH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Versus US-Guided Subcostal TAP Block After Laparoscopic Cholecystectomy
Status: UNKNOWN
Conditions: Cholecystitis; Gallstone
Interventions: PROCEDURE: Laparoscopic TAP|PROCEDURE: US TAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Bevacizumab in the Neodjuvant Treatment of Inflammatory Breast Cancer
Status: UNKNOWN
Conditions: Inflammatory Breast Cancer
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Cyclophosphamide|DRUG: epirubicin hydrochloride|DRUG: fluorouracil|DRUG: Docetaxel|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renin-angiotensin System Blockade Benefits in Clinical Evolution and Ventricular Remodeling After Transcatheter Aortic Valve Implantation (RASTAVI)
Status: UNKNOWN
Conditions: Transcatheter Aortic Valve Replacemen|Angiotensin-Converting Enzyme Inhibitors
Interventions: DRUG: Ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Value of Novel MR Imaging Techniques for the Primary Staging and Restaging of Rectal Cancer
Status: COMPLETED
Conditions: Rectal Neoplasms|Magnetic Resonance Imaging|Neoplasms Staging
Interventions: DRUG: GADOFOSVESET TRISODIUM 244 Mg in 1 mL INTRAVENOUS INJECTION, SOLUTION [Ablavar]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reduced Intensity BMT for Immune Dysregulatory and Bone Marrow Failure Syndromes Using Post-Transplant Cyclophosphamide
Status: RECRUITING
Conditions: Primary Immune Deficiency Disorder|Immune Deficiency Disease|Bone Marrow Failure
Interventions: DRUG: Alemtuzumab|DRUG: Fludarabine|DRUG: Melphalan|RADIATION: Low Dose Total Body Irradiation|DRUG: Cyclophosphamide|DRUG: Tacrolimus|DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Initial Caries Lesions on Proximal Surfaces of Primary and Permanent Posterior Teeth
Status: UNKNOWN
Conditions: Dental Caries|Compliance Behavior
Interventions: PROCEDURE: Resin Infiltration|PROCEDURE: 30% Silver Diammine Fluoride|PROCEDURE: Dental Flossing|PROCEDURE: Resin Infiltration Placebo|PROCEDURE: 30% Silver Diammine Fluoride Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation of a Molecular Diagnostic for Pediatric Acute Gastroenteritis: The FilmArray GI Panel IMPACT Study
Status: COMPLETED
Conditions: Infectious Gastroenteritis
Interventions: DEVICE: FilmArray™ Gastrointestinal (GI) Panel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Downstream Effects of Personalized 'Top-down' Participation-based Interventions Among Youth With Physical Disabilities
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injuries|Spina Bifida|Musculoskeletal Disorder|Juvenile Arthritis|Amputation|Cerebral Palsy
Interventions: BEHAVIORAL: Engagement in a 8-week community-based activity program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study With GLPG1972
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: GLPG1972 600 mg oral solution fasted|DRUG: GLPG1972 600 mg oral tablet fasted|DRUG: GLPG1972 600 mg oral tablet fed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abdominoperineal Extra-Elevators Rectal Resection for Cancer: Prone Position vs. Supine Position
Status: TERMINATED
Conditions: Rectal Cancer|Abdominoperineal Resection
Interventions: PROCEDURE: Abdominoperineal extra-elevators rectal resection for low lying rectal cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Patient Controlled & Continuous Epidural Analgesia in Thoraco-abdominal Surgeries in Cancer Patients
Status: COMPLETED
Conditions: Pain
Interventions: OTHER: Continous Epidural Analgesia|OTHER: Patient Controlled Epidural Analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treating Kidney Donors With Valganciclovir to Reduce Viral Transmission to Recipients
Status: COMPLETED
Conditions: EBV Viremia|CMV Viremia
Interventions: DRUG: Valganciclovir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: BAY 43-9006 in Previously Untreated Patients With Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: BAY 43-9006|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Partners in Children's Health (CSN): A Randomized Trial of an Attachment Based Intervention
Status: RECRUITING
Conditions: Respiratory Disease|Inflammation|Insufficient Sleep|Digestive Disease|Skin Conditions|Body Mass Index|Infections|Allergies|Congestion|Antibiotic Use|Overweight and Obesity
Interventions: BEHAVIORAL: Attachment and Biobehavioral Catch-Up|OTHER: Home-Based Book-of-the-Week
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Paracetamol and Neuropathic Pain
Status: TERMINATED
Conditions: Neuropathic Pain
Interventions: DRUG: paracetamol|OTHER: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Post Infectious Inflammatory Reaction (PIIR) Concerning Children After Streptococcus Pneumoniae, Streptococcus Pyogenes and Neisseria Meningococcus Invasive Infection
Status: UNKNOWN
Conditions: Streptococcus Pneumonia|Streptococcus Pyogenes Infection|Neisseria Meningitides Meningitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Short Term Follow-up of Patient Implanted With the Metatarso-Phalangeal Prosthesis METIS®
Status: COMPLETED
Conditions: Hallux Rigidus|Hallux Limitus|Hallux Valgus|Osteoarthritis|Rheumatoid Arthritis - Ankle and/or Foot
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of the Nanodropper Device on Intraocular Pressure in Patients With Glaucoma
Status: RECRUITING
Conditions: Glaucoma|Ocular Hypertension|Open Angle Glaucoma
Interventions: DEVICE: Nanodropper
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Aim is to Estimate the Total Amount of Insulin-producing Cells in the Pancreas by MRI.
Status: TERMINATED
Conditions: Diabetes Mellitus
Interventions: PROCEDURE: MR imaging|PROCEDURE: Glucose clamp|DRUG: Arginine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Magnesium Sulfate Versus Dexmedetomidine on Anesthesia Awakening.
Status: COMPLETED
Conditions: Cholecystectomy
Interventions: DRUG: Dexmedetomidine|DRUG: Sham treatment|DRUG: Magnesium Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunization of HLA-A201 Patients With Metastatic Melanoma Using a Combination of Immunodominant Peptides From Three Melanoma Antigens, MART-1, GP100 and Tyrosinase
Status: COMPLETED
Conditions: Melanoma|Neoplasm Metastasis
Interventions: BIOLOGICAL: Immunodominant peptides from three melanoma antigens, MART-1, GP100 and tyrosinase
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Oral Cladribine in Early Multiple Sclerosis (MS)
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Cladribine|DRUG: Placebo|DRUG: Rebif® new formulation (RNF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Acetaminophen and PRP Therapy for Knee OA
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Intra-articular injection of PRP|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Restoring Emotional, Sexual, and Physical Empowerment Through CBT & Trauma-sensitive Care: A Chronic Pelvic Pain Intervention
Status: COMPLETED
Conditions: Pelvic Pain|Stress Disorders, Traumatic
Interventions: BEHAVIORAL: Trauma-sensitive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-ranging Study of Oral PHA-022121 for Prophylaxis Against Angioedema Attacks in Patients With Hereditary Angioedema Type I or Type II
Status: ACTIVE_NOT_RECRUITING
Conditions: Hereditary Angioedema|Hereditary Angioedema Type I|Hereditary Angioedema Type II|Hereditary Angioedema Types I and II|Hereditary Angioedema Attack|Hereditary Angioedema With C1 Esterase Inhibitor Deficiency|Hereditary Angioedema - Type 1|Hereditary Angioedema - Type 2|C1 Esterase Inhibitor Deficiency|C1 Inhibitor Deficiency
Interventions: DRUG: Deucrictibant low dose|DRUG: Deucrictibant high dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Continuous Glucose Monitor in Hospitalized, Post-operative Patients With Diabetes Mellitus
Status: SUSPENDED
Conditions: Diabetes Mellitus
Interventions: DEVICE: Continuous Glucose Monitor (CGM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Visual Feedback Goggle for Positional Vertigo Treatment
Status: UNKNOWN
Conditions: Positional Vertigo|Vertigo
Interventions: DEVICE: Goggle with 20 degree error|DEVICE: Optimized Goggle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Radiation-protection Effect of Amifostine in Locally Advanced Rectal Cancer
Status: UNKNOWN
Conditions: Locally Advanced Rectal Cancer
Interventions: RADIATION: Radiation|DRUG: Capecitabine|DRUG: Irinotecan|DRUG: Amifostine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ESP vs ESP With PECS
Status: COMPLETED
Conditions: Postoperative Pain|Mitral Valve Disease
Interventions: PROCEDURE: Erector Spinae Plane blockade|PROCEDURE: Pectoral Fascia block|DRUG: Oxycodone|PROCEDURE: general anesthesia|DRUG: paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: RHA® Redensity With New Anesthetic Agent - Perioral Rhytids
Status: COMPLETED
Conditions: Aging|Pain
Interventions: DEVICE: RHA® Redensity with new anesthetic agent|DEVICE: RHA® Redensity with lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Erdafitinib Intravesical Delivery System in Japanese Participants With Bladder Cancer
Status: RECRUITING
Conditions: Urinary Bladder Neoplasms|Receptors, Fibroblast Growth Factor
Interventions: DRUG: Erdafitinib Intravesical Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Probiotic Supplementation on Crying Time in Infantile Colic
Status: WITHDRAWN
Conditions: Colic, Infantile
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri DSM17938|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: rTMS Therapy for Primary Orthostatic Tremor
Status: COMPLETED
Conditions: Primary Orthostatic Tremor
Interventions: DEVICE: Magstim RapidStim2|DEVICE: Sham Magstim RapidStim2|OTHER: Fahn-Tolosa-Marin Tremor Rating Scale (TRS)|OTHER: Timed "Up & Go" Test (TUG) test|OTHER: 10m walk test|OTHER: Tremor electrophysiology|OTHER: Cerebellar-brain Inhibition (CBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 2-D and 3-D Laparoscopic Hysterectomy
Status: UNKNOWN
Conditions: Fibroma, Bleeding
Interventions: DEVICE: 3-D laparoscopy|DEVICE: 2-D laparoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sexual and Reproductive Health (Including PrEP and HBV) for Female Sex Workers in Côte d'Ivoire
Status: UNKNOWN
Conditions: HIV Infections|Viral Hepatitis B|Sexually Transmitted Diseases|Contraception
Interventions: OTHER: Comprehensive package of sexual and reproductive health services
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Methotrexate-Inadequate Response Study
Status: COMPLETED
Conditions: Rheumatoid Arthritis (RA)
Interventions: DRUG: Subcutaneous (SC) Abatacept|DRUG: Intravenous (IV) Abatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I AZD2171 in Patients With Relapsed or Refractory AML and Elderly Patients With DeNovo or Secondary AML
Status: COMPLETED
Conditions: Leukaemia|Myelocytic|Acute
Interventions: DRUG: AZD2171
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atezolizumab and Cobimetinib or Idasanutlin in Participants With Stage IV or Unresectable Recurrent Estrogen Receptor Positive Breast Cancer
Status: TERMINATED
Conditions: Stage III Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer|Estrogen Receptor-positive|HER2/Neu Negative
Interventions: DRUG: Atezolizumab|DRUG: Cobimetinib|DRUG: Idasanutlin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-versus Short-Axis Ultrasound Guidance for Subclavian Vein Cannulation
Status: COMPLETED
Conditions: Vascular Access Complication|Perioperative/Postoperative Complications
Interventions: DEVICE: Long Axis strategy|DEVICE: Short Axis Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Wits Workout Wellness Program for Older Adults
Status: COMPLETED
Conditions: Cognitive Decline|Social Isolation|Health Behaviors|Self Efficacy
Interventions: BEHAVIORAL: Wits Workout Program|OTHER: Control Group that receives intervention after the study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The USGI Medical ESSENTIAL Study for Weight Loss
Status: COMPLETED
Conditions: Obesity
Interventions: DEVICE: placement of g-Cath EZ suture anchors|PROCEDURE: Sham procedure|BEHAVIORAL: Diet and Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Positron-Emission Tomography With Vesicular Monoamine Transporter Ligand ([18F]-DTBZ) In Healthy Elderly And Young Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 18F-DTBZ AV-133
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Immunogenicity Study of Aleph Inactivated Split Influenza Vaccine
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: recombinant hepatitis b vaccine|BIOLOGICAL: Aleph influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: AVS After 1mg DST to Determine Subtype in PA
Status: COMPLETED
Conditions: Primary Aldosteronism
Interventions: DRUG: Dexamethasone 1 MG Oral Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Closure Versus Non Closure of Subcutaneous Tissue After Cesarean Section in Diabetic Patients
Status: COMPLETED
Conditions: Abdominal Delivery
Interventions: OTHER: closure of subcutaneous tissue|OTHER: No closure of subcutaneous tissue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Chlorhexidine Gluconate Concentration on Skin of Human Subjects Following Multiple Application Times
Status: COMPLETED
Conditions: General Skin Cleansing
Interventions: COMBINATION_PRODUCT: Chlorhexidine Gluconate with HUBS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Hemodynamic Effect of Simvastatin With Beta Blockers in Clinical Portal Hypertension
Status: UNKNOWN
Conditions: Liver Cirrhosis|Portal Hypertension.
Interventions: DRUG: Simvastatin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of BTX-A51 in People With Relapsed or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: BTX-A51|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Efficacy and Safety of 122-0551 in Subjects With Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis|Plaque Psoriasis
Interventions: DRUG: 122-0551|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Clinical Specificity of the Active Anthrax Detect™ Plus (AAD Plus) Lateral Flow Immunoassay (LFI)
Status: COMPLETED
Conditions: Anthrax
Interventions: DIAGNOSTIC_TEST: Active Anthrax Detect™ Plus (AAD Plus)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Exenatide on Weight and Hunger in Obese, Healthy Women
Status: COMPLETED
Conditions: Obesity|Impaired Glucose Tolerance
Interventions: DRUG: exenatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prebiotic Supplementation and Intestinal Barrier Function in Elderly: a RCT
Status: COMPLETED
Conditions: Prebiotics|Aged
Interventions: DIETARY_SUPPLEMENT: Naxus|DIETARY_SUPPLEMENT: Oatwell|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Antispasmodic Drug for Diagnosis Proximal Tubal Occlusion on Hysterosalpingography
Status: COMPLETED
Conditions: Tubal Obstruction
Interventions: PROCEDURE: hysterosalpingography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Donafenib and Toripalimab Combined With TACE in Patients With Unresectable Hepatocellular Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Unresectable Hepatocellular Carcinoma
Interventions: DRUG: Donafenib Tosilate Tablets|BIOLOGICAL: Toripalimab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy + Sintilimab + Bevacizumab Biosimilar for uHCC With PVTT
Status: RECRUITING
Conditions: Hepatocellular Carcinoma Non-resectable
Interventions: COMBINATION_PRODUCT: radiotherapy combined with sintilimab and bevacizumab biosimilar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Chronic Hepatitis C Infection
Status: COMPLETED
Conditions: Chronic Hepatitis C Infection
Interventions: DRUG: ABT-450/r/ABT-267, ABT-333|DRUG: Ribavirin|DRUG: Placebo for ABT-450/r/ABT-267|DRUG: Placebo for ABT-333|DRUG: Placebo for ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Natural Killer Cells and Bortezomib to Treat Cancer
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia (CML)|Pancreatic Ca|Colon/Rectal Ca|Multiple Myeloma|Carcinoma, Non-Small -Cell Lung
Interventions: DRUG: Bortezomib|BIOLOGICAL: NK cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventive Catheter Ablation for Ventricular arrhythmiaS in Patients With End-sTage Heart faiLure
Status: NOT_YET_RECRUITING
Conditions: Heart Failure|Arrhythmia, Ventricular|Cardiomyopathy Ischemic|Catheter Ablation|Heart Transplantation|Left Ventricular Assist Device
Interventions: PROCEDURE: Catheter ablation|DRUG: Medical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dexmedetomidine and Esketamine on Catheter-related Bladder Discomfort
Status: RECRUITING
Conditions: Urinary Catheter|Catheter-related Bladder Discomfort|Dexmedetomidine|Esketamine
Interventions: DRUG: Normal saline|DRUG: Dexmedetomidine|DRUG: Esketamine|DRUG: Combined dexmedetomidine-esketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Immunogenicity of V260 in Healthy Chinese Infants (V260-024)
Status: COMPLETED
Conditions: Rotavirus Gastroenteritis
Interventions: BIOLOGICAL: V260|BIOLOGICAL: Placebo to V260|BIOLOGICAL: OPV|BIOLOGICAL: DTaP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Lactobacillus Plantarum PS128 in Patients With Tourette's Syndrome
Status: COMPLETED
Conditions: Tourette's Syndrome
Interventions: DIETARY_SUPPLEMENT: PS128
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Thoratec HeartMate II Left Ventricular Assist System (LVAS) for Destination Therapy
Status: COMPLETED
Conditions: Heart Failure, Congestive|Ventricular Dysfunction|Cardiomyopathies
Interventions: DEVICE: Left Ventricular Assist System (LVAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abdominal Rectus Diastasis Microscopy and Rehabilitation (AMIRE)
Status: RECRUITING
Conditions: Abdominal Rectus Diastasis
Interventions: OTHER: Postoperative rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Preoperative N1539 in Colorectal Surgery
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: N1539|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Levothyroxine and the Influence of Co-administered Tablets on the Pharmacokinetics of Semaglutide Administered Orally in Healthy Subjects.
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: Semaglutide|DRUG: SNAC|DRUG: Levothyroxine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internal Compartment Knee Osteoarthritis: ODRA (Orthosis Distraction and Rotation for osteoArthritis) Made-to-measure Hinged Knee Brace Versus Usual Care.
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: brace ODRA (PROTEOR company)|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Conventional Bite Wing Radiography Versus Stationary Intraoral Tomosynthesis, a Comparison Study
Status: COMPLETED
Conditions: Dental Caries
Interventions: DEVICE: Stationary intraoral tomosynthesis|DEVICE: Standard conventional bitewing radiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Peppermint Oil for the Treatment of Irritable Bowel Syndrome: Optimizing Therapeutic Strategies Using Targeted Delivery
Status: COMPLETED
Conditions: Irritable Bowel Syndrome|Abdominal Pain|Colonic Diseases, Functional
Interventions: DRUG: Ileocolonic release peppermint oil|DRUG: Placebo|DRUG: Small intestinal release peppermint oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Double Blind, Placebo-Controlled, Randomized Study in Subjects With Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: B244|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Utilization of Uterine Manipulator in Abdominal Hysterectomy
Status: COMPLETED
Conditions: Sexual Function Disturbances
Interventions: DEVICE: The uterine manipulator which is primarily used in laparoscopic hysterectomy to accurately locate the colpotomy site. We adopted this device in abdominal hysterectomy.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS)
Status: TERMINATED
Conditions: Complex Regional Pain Syndromes
Interventions: DRUG: Placebo|DRUG: Ethosuximide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-Interventional Long Term Follow-up Study of Participants Previously Enrolled in the RESTORE Study
Status: ENROLLING_BY_INVITATION
Conditions: Retinitis Pigmentosa|Retinitis|Retinal Diseases|Eye Diseases|Eye Diseases, Hereditary|Retinal Dystrophies|Retinal Degeneration
Interventions: BIOLOGICAL: Gene Therapy product-MCO-010
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Plasma Tumor-promoting Factors and Immune Function After Laparotomy, Cytoreductive Surgery and HIPEC vs. PIPAC in Patients With Peritoneal Metastasis
Status: UNKNOWN
Conditions: Peritoneal Cancer|Chemotherapy-Induced Change
Interventions: COMBINATION_PRODUCT: PIPAC with oxaliplatin|PROCEDURE: Cytoreductive surgery and Hyperthermic IntraPeritoneal Chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Personalized Neo-antigen Vaccine in Advanced Solid Tumors (NeoPepVac)
Status: UNKNOWN
Conditions: Malignant Melanoma, Metastatic|Non Small Cell Lung Cancer Metastatic|Bladder Urothelial Carcinoma, Metastatic
Interventions: DRUG: EVAX-01-CAF09b
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-dose-escalation Safety and Pharmacokinetic Study of SAR3419 as Single Agent in Relapsed/Refractory B-cell Non Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma|Non-Hodgkin
Interventions: DRUG: SAR3419
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-vaginal Electrical Stimulation Device Compared to Sham Device for Chronic Pelvic Pain
Status: COMPLETED
Conditions: Pelvic Pain
Interventions: DEVICE: ApexM|DEVICE: Sham Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Assessment of a Treatment Combining Rituximab and Belimumab in Adults With Persistent Immune Thrombocytopenia
Status: COMPLETED
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Rituximab (Mabthera ®) Belimumab (Benlysta ®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuronal Inertia in Propofol Anesthesia
Status: COMPLETED
Conditions: General Anesthesia|Propofol Pharmacodynamics|Propofol Target Controlled Infusion|Loss of Consciousness and Recovery of Consciousness|Propofol Plasma Concentration
Interventions: DRUG: propofol targel controlled infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: BabyQ's: Randomized Controlled Trial of Health Messaging in Pregnancy and Infancy
Status: COMPLETED
Conditions: Pregnancy Related|Infant Development
Interventions: BEHAVIORAL: Mobile messaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Dietary Additive Phosphorus on Proteinuria and Fibroblast Growth Factor-23
Status: COMPLETED
Conditions: Albuminuria
Interventions: OTHER: Higher phosphorus period|OTHER: Lower phosphorus period
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Safety and Tolerability of PRO-229 Ophthalmic Solution Compared to Lagricel® Ofteno PF
Status: NOT_YET_RECRUITING
Conditions: Dry Eye Disease|Ocular Surface Disease
Interventions: DRUG: PRO-229|DRUG: Lagricel® Ofteno PF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Botulinum Toxin in Disabling Multiple Sclerosis (MS) Tremor
Status: COMPLETED
Conditions: Multiple Sclerosis|Tremor
Interventions: DRUG: Botulinum Toxin Type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of 4 Investigational HSV 2 Vaccines in Adults With Recurrent Genital Herpes Caused by HSV 2
Status: TERMINATED
Conditions: Genital Herpes
Interventions: BIOLOGICAL: HSV 2 Formulation 1|BIOLOGICAL: HSV 2 Formulation 2|BIOLOGICAL: HSV 2 Formulation 3|BIOLOGICAL: HSV 2 Formulation 4|BIOLOGICAL: HSV 2 Formulation 5|BIOLOGICAL: HSV 2 Formulation 6|BIOLOGICAL: Sodium Chloride 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single-dose Linaclotide for Capsule Endoscopy Preparation
Status: COMPLETED
Conditions: Crohn's|Ulcerative Colitis|Gastrointestinal Bleeding
Interventions: DRUG: Linaclotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Amino Acids in Patients With Anorexia Nervosa: Double-blind Randomized Study Versus Placebo
Status: UNKNOWN
Conditions: Anorexia Nervosa
Interventions: DIETARY_SUPPLEMENT: Amino-Ther Pro|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Clinical Trial to Evaluate the Safety and Immunogenicity of a Prophylactic HIV Vaccine Candidate
Status: NOT_YET_RECRUITING
Conditions: Hiv
Interventions: DRUG: BG505 SOSIP.664 gp140 Vaccine, Adjuvanted (3M-052 AF plus alum)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Potential Role of Water-soluble Ubiquinol in Complementary Therapy for Pediatric Dilated Cardiomyopathy
Status: COMPLETED
Conditions: Pediatric Dilated Cardiomyopathy
Interventions: DIETARY_SUPPLEMENT: Water-soluble Ubiquinol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial Exploring Combined Neoadjuvant Therapy With Pembrolizumab/Lenvatinib + Adjuvant Pembrolizumab in Pat. With NSCLC
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: neoadjuvant therapy with Pembrolizumab/Lenvatinib|PROCEDURE: Surgery|DRUG: Adjuvant Treatment Phase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing the Probability Algorithm for Pulmonary Hypertension Echocardiography
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Hypertension
Interventions: DIAGNOSTIC_TEST: Electrocardiogram|DIAGNOSTIC_TEST: Transthoracic echocardiogram|DIAGNOSTIC_TEST: Right heart catheter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Platelet-rich Plasma and Synovial Cytokines in Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: Intra-articular injection of platelet-rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Intra-arterial Chemotherapy With Cisplatin and Mitomycin-C in Patients With Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma|Liver Cancer
Interventions: DRUG: mitomycin-c, cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Same-session MR-only Simulation and Treatment With Stereotactic MRI-guided Adaptive Radiotherapy (SMART) for Oligometastases of the Spine
Status: COMPLETED
Conditions: Oligometastases of the Spine
Interventions: DEVICE: MRIdian Linac System from ViewRay|RADIATION: Stereotactic MRI-guided Adaptive Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intradermal Rabies Immunization Using NanoJect: A Comparative Study
Status: COMPLETED
Conditions: Intradermal (ID) Vaccination Device
Interventions: DEVICE: NanoJect device (DebioJect™)|DEVICE: Classical syringe (1mL Becton Dickinson (BD) Luer-Lock™) with a 25 Guage (G) needle (Terumo® Neolus)|DEVICE: Classical syringe (1mL BD Luer-Lock™) with a 22G needle (Terumo® Neolus)|DRUG: Vaccin rabique Pasteur®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Laparoscopic Repair of Giant Hiatal Hernias With Nitinol-framed Lightweight Polytetrafluoroethylene Mesh
Status: UNKNOWN
Conditions: Hernia, Hiatal
Interventions: DEVICE: Nitinol-framed lightweight PTFE mesh for hiatal repair|DEVICE: Partially absorbable lightweight mesh for hiatal repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study to Evaluate the Pharmacokinetics of BAT2206 vs Stelara® in Healthy Subjects
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: BAT2206|DRUG: Stelara(US-licensed)|DRUG: Stelara(EU-licensed)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT