pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies
Status: RECRUITING
Conditions: Acute Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Acute Biphenotypic Leukemia|Acute Undifferentiated Leukemia
Interventions: OTHER: Ossium HPC Marrow, Bone Marrow Transplant|OTHER: Pre-transplant conditioning - Myeloablative (MAC)|OTHER: Pre-transplant conditioning - Reduced Intensity (RIC)|OTHER: Post-transplant treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Healing With Epidermal Fractional Blistergrafting (CellutomeTM) to Acellular Technique
Status: COMPLETED
Conditions: Burn Wound
Interventions: DEVICE: Cellutome Device|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Basic Assessment of Safety and Minimally Invasive Stimulation Via Injectrode
Status: COMPLETED
Conditions: Chronic Lower Limb Pain
Interventions: DEVICE: Neuronoff BASMATI Injectrode
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Prospective Observational Study to Evaluate the Quality of Life and the Costs in a Real Life Setting in Patients Who Are Treated With 90Y-Zevalin
Status: COMPLETED
Conditions: Lymphoma, Follicular|Non-Hodgkin Lymphoma
Interventions: DRUG: [90]Y-ibritumomab tiuxetan (Zevalin, BAY86-5128)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TLI & ATG for Non-Myeloablative Allogeneic Transplantation for MDS and MPD
Status: COMPLETED
Conditions: Myeloproliferative Disorders|Blood Cancer|Myelodysplastic Syndromes
Interventions: PROCEDURE: Total Lymphoid Irradiation (TLI)|PROCEDURE: Anti-Thymocyte Globulin as Conditioning (ATG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of a Bolus Administration of Ephedrine and Phenylephrine on the Spinal Oxygen Saturation, Measured With NIRS.
Status: COMPLETED
Conditions: Influence of Vasoactive Medication on Spinal Oxygenation
Interventions: DRUG: Ephedrine Hydrochloride 3 MG/ML|DRUG: Phenylephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Desloratadine 5, 10 and 20mg in Patients With Cold Urticaria
Status: COMPLETED
Conditions: Urticaria
Interventions: DRUG: Desloratadine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of ORM-12741 on Agitation/Aggression Symptoms in Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: ORM-12741|DRUG: ORM-12741|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Technical Strategies for Pancreatic Fistula Prevention After Pancreaticoduodenectomy in High-risk Pancreatic Remnant
Status: COMPLETED
Conditions: Pancreatic Fistula
Interventions: PROCEDURE: Pancreaticogastrostomy with external drain|PROCEDURE: Pancreaticojejunostomy with transanastomotic drain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Surgical Site Infection in Perforated Appendicitis After Peritoneal Lavage With Super-oxidised Solution
Status: COMPLETED
Conditions: Perforated Appendicitis
Interventions: DRUG: Superoxidized Water|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hand and Arm Motor Recovery Via Non-invasive Electrical Spinal Cord Stimulation After Stroke
Status: RECRUITING
Conditions: Stroke, Ischemic|Chronic Stroke
Interventions: DEVICE: Non-invasive Electrical Spinal Cord Stimulation|OTHER: Activity Based Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMProving DRug Dosing and Outcomes for Single VEntricle Patients With Fontan Associated Liver Disease
Status: RECRUITING
Conditions: Fontan Circulation
Interventions: DRUG: Sildenafil 10mg oral tablet (participants <20kg), or 20mg oral tablet (participants ≥20kg)|DRUG: Pravastatin 20 mg oral tablet (ages <13 years), or 40 mg oral tablet (≥14 years)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TEAM (Thiotepa, Etoposide, Cytosar, Melphalan ) for AutoSCT in Lymphoma
Status: COMPLETED
Conditions: Malignant Lymphoma
Interventions: DRUG: Thiotepa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crossover, Single Dose Randomized, Bioequivalence of Ketoprofen Lysine Salt Immediate Release vs Oral Solution
Status: COMPLETED
Conditions: Pain Disorders
Interventions: DRUG: KSL 40 mg|DRUG: OKi® 80 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of Sarpogrelate SR in Patients With Chronic Artery Occlusive Disease
Status: COMPLETED
Conditions: Arterial Occlusive Diseases|Intermittent Claudication
Interventions: DRUG: Sarpogrelate SR|DRUG: Sarpogrelate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled ZYESAMI™ (Aviptadil Acetate) for the Treatment of Severe COVID-19
Status: TERMINATED
Conditions: SARS-CoV 2|COVID|ARDS|ALI|Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)|Dyspnea
Interventions: DRUG: ZYESAMI™ (aviptadil acetate)|DRUG: Placebo|DEVICE: Nebulized administration of ZYESAMI™ or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploratory Clinical Study of CD19-targeted CAR-T and CAR-DC in the Treatment of Relapsed and Refractory B-cell Lymphoma
Status: RECRUITING
Conditions: Relapsed and Refractory B-cell Lymphoma
Interventions: BIOLOGICAL: CD19 CAR-T and CD19 CAR-DC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selinexor, Cyclophosphamide and Prednisone in Myeloma
Status: COMPLETED
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: DRUG: Selinexor|DRUG: Cyclophosphamide|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cryotherapy vs. LEEP to Treat Cervical Intraepithelial Neoplasia (CIN) 2/3 Among HIV-positive Women
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia
Interventions: PROCEDURE: Loop Electrosurgical Excision Procedure (LEEP)|PROCEDURE: Cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Absolute Bioavailability of Oral Sylibin
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: silybin phosphatidylcholine|DRUG: Legalón SIL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Monitoring of Uterine Activity and Fetal Heart Rate
Status: RECRUITING
Conditions: Fetal Heart Rate or Rhythm Abnormality Affecting Newborn During Labor|Uterine Contractions|Obstetric Complication
Interventions: DEVICE: TrueLabor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Non-Comparative Study to Assess the Safety of MabThera (Rituximab) in Patients With Rheumatoid Arthritis.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Methotrexate|DRUG: rituximab [MabThera/Rituxan]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Omadacycline vs. Oral Nitrofurantoin for the Treatment of Cystitis
Status: COMPLETED
Conditions: Uncomplicated Urinary Tract Infection|Cystitis
Interventions: DRUG: Omadacycline tablets|DRUG: Nitrofurantoin capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Degree of Benefit From Low-Frequency Acoustic Amplification Using the Advanced Bionics Acoustic Earhook
Status: WITHDRAWN
Conditions: Cochlear Implant|Cochlear Hearing Loss
Interventions: DEVICE: Advanced Bionics' Acoustic Earhook
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Injection Site for Serratus Anterior Plane Block in Reconstructive Breast Surgery
Status: WITHDRAWN
Conditions: Pain, Postoperative
Interventions: DRUG: Bupivacaine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized Controlled 8-Week Crossover Evaluation of Compression Bandage Systems for Venous Leg Ulcers
Status: COMPLETED
Conditions: Venous Ulcer
Interventions: DEVICE: Coban 2 Layer Compression System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing GS500 in Functional Constipation
Status: UNKNOWN
Conditions: Constipation - Functional
Interventions: DEVICE: GS500|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Effects of Lactobacillus Reuteri DSM 17938 in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Lactobacillus Reuteri|DIETARY_SUPPLEMENT: Lactobacillus Reuteri DSM17938
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Extended Infusion of β-lactam Antibiotics for the Treatment of Febrile Neutropenia in Hematologic Patients
Status: UNKNOWN
Conditions: Febrile Neutropenia
Interventions: DRUG: Piperacillin-Tazobactam 4 g-0.5 g|DRUG: Cefepime 2000 mg|DRUG: Meropenem 1000 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Exercise in Combination With Epoetin Alfa
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Epoetin Alfa|BEHAVIORAL: Exercise|BIOLOGICAL: Autologous Peripheral Blood Stem Cell Transplantation|BIOLOGICAL: Red Blood Cell Transfusion|DRUG: Thalidomide|DRUG: Heparin, Low-Molecular-Weight|BIOLOGICAL: Platelet Transfusion|DRUG: Melphalan|DRUG: Epoetin Alfa|DRUG: Total Therapy II|BIOLOGICAL: Red Blood Cell Transfusion|DRUG: Thalidomide|DRUG: Heparin, Low-Molecular-Weight|BIOLOGICAL: Platelet Transfusion|DRUG: Melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prediction and Maintenance of Sinus Rhythm Among Atrial Fibrillation Patients
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Unique measurement (AutoSTRAIN) by a commercial software program (TOMTEC-ARENA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine and Midazolam Nebulization as Sedation During Cesarean Delivery in Pre-eclampsia
Status: RECRUITING
Conditions: Procedural Sedation
Interventions: DRUG: Nebulized dexmedetomidine|DRUG: Nebulized midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inherited Risk Evaluation Tool (InheRET): Identifying Patients at Increased Risk for Hereditary Disease
Status: UNKNOWN
Conditions: Hereditary Cancer-Predisposing Syndrome
Interventions: OTHER: InheRET|OTHER: Patient Acceptance|OTHER: Physician Acceptance Survey
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Glucocorticoids and Pulmonary Hypertension
Status: UNKNOWN
Conditions: Pulmonary Hypertension Due to Lung Diseases and Hypoxia|Pulmonary Hypertension|Bronchopulmonary Dysplasia
Interventions: DRUG: GlucoCorticoid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Search for Predictive Factors of Resistance to Treatment for Metastatic Castration-resistant Prostate Cancer by Studying the Expression of microRNAs
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer|Resistance, Disease|MicroRNAs
Interventions: BIOLOGICAL: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Uncertainty and Firearms: Obtaining Secure Storage
Status: RECRUITING
Conditions: Anxiety
Interventions: BEHAVIORAL: Lethal Means Counseling (LMC)|BEHAVIORAL: CBT for Uncertainty - Enhanced (CUE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Randomized Study, Comparing Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC /VI) Single Inhaler Triple Therapy, Versus Multiple Inhaler Therapy (Budesonide/Formoterol Plus Tiotropium) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: budesonide/formoterol|DRUG: albuterol/salbutamol|DRUG: FF/UMEC/VI|DRUG: Placebo to match budesonide/formoterol|DRUG: tiotropium|DRUG: Placebo to match FF/UMEC/VI|DRUG: placebo to match tiotropium|DEVICE: ELLIPTA|DEVICE: MDI|DEVICE: HandiHaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Mediterranean-DASH Intervention for Neurodegenerative Delay Plus Forest Bathing
Status: COMPLETED
Conditions: High Blood Pressure
Interventions: BEHAVIORAL: MIND diet|BEHAVIORAL: Mind diet plus Forest Bathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the SafeSpace App Intervention
Status: RECRUITING
Conditions: Health Behavior|Health Care Utilization|Unprotected Sex|Sexually Transmitted Infections
Interventions: BEHAVIORAL: SafeSpace Sexual Health|BEHAVIORAL: SafeSpace General Health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ESK981 and Nivolumab for the Treatment of Metastatic Castration Resistant Prostate Cancer
Status: TERMINATED
Conditions: Castration Levels of Testosterone|Castration-Resistant Prostate Carcinoma|Metastatic Prostate Carcinoma|Prostate Carcinoma Metastatic in the Bone|Stage IVB Prostate Cancer AJCC v8
Interventions: DRUG: Pan-VEGFR/TIE2 Tyrosine Kinase Inhibitor CEP-11981|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hepatopulmonary Radio-sterilization With Immunotherapy
Status: NOT_YET_RECRUITING
Conditions: Colon Cancer|Liver Metastasis Colon Cancer|Rectal Cancer
Interventions: RADIATION: Hepatopulmonary radio-sterilization
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of ITP With Rituximab and / or Accutane
Status: UNKNOWN
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Rituximab plus methylprednisolone|DRUG: methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The SmartFeeding4Kids: Study of a New Web-based Food Parenting Intervention
Status: RECRUITING
Conditions: Parental Feeding Practices and Children's Healthy Diet
Interventions: BEHAVIORAL: Behavioral change intervention;|BEHAVIORAL: Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Malaria and the Safety of Iron Supplements and Iron Fortification
Status: COMPLETED
Conditions: Iron Deficiency
Interventions: DIETARY_SUPPLEMENT: Ferrous sulfate|DIETARY_SUPPLEMENT: Ferrous sulfate|DIETARY_SUPPLEMENT: Ferrous sulfate|DIETARY_SUPPLEMENT: Ferrous sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: High-dose Ibuprofen for Patent Ductus Arteriosus (PDA) in Preterm Infant
Status: COMPLETED
Conditions: Ductus Arteriosus, Patent
Interventions: DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Lumiracoxib and Ibuprofen on Blood Pressure and Urinary Eicosanoid Excretion in Osteoarthritis Patients With Controlled Hypertension
Status: COMPLETED
Conditions: Osteoarthritis With Controlled Hypertension
Interventions: DRUG: Lumiracoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Research on the Combined-Modality Treatment Model of Bladder Preservation in Muscular Invasive Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: PROCEDURE: Intensity modulated radiation therapy, Radical cystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of LIXIsenatide on the Renal System
Status: COMPLETED
Conditions: Diabetic Kidney Disease|Diabetic Nephropathy|Diabetes Mellitus|Glucagon-Like Peptide 1
Interventions: DRUG: Lixisenatide|DRUG: Insulin glulisine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cortical Stimulation to Treat Obsessive Compulsive Disorder
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: Standard Therapeutic Deep Brain Stimulation|DEVICE: Cortical Stimulation for PFC|DEVICE: Cortical Stimulation for ACC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Daily Nicotine Patch Application on Mechanical Ventilation Weaning in Smoking Patients
Status: UNKNOWN
Conditions: Smoking|Mechanical Ventilation|Intensive Care
Interventions: DRUG: Nicotine patch|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Exploratory Study About the Effect of Using Double Filtration Plasmapheresis (DFPP) Removing Inflammatory Cytokines, Lipids and Toxic Metal Ions in Peripheral Blood in Adults
Status: NOT_YET_RECRUITING
Conditions: Sub-healthy|Hyperlipidemia|Toxic Metal Ions Accumulation
Interventions: DEVICE: DFPP|DEVICE: DFPP|DEVICE: DFPP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Abemaciclib in Indian Women With Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms|Neoplasm Metastasis
Interventions: DRUG: Abemaciclib|DRUG: Nonsteroidal Aromatase Inhibitor (NSAI)|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Adding Vildagliptin on Beta Cell Function and Cardiovascular Risk Markers in Patients With Moderate Metabolic Control During Metformin Monotherapy
Status: UNKNOWN
Conditions: Diabetes Mellitus Type II
Interventions: DRUG: Metformin|DRUG: Metformin|DRUG: Vildagliptin|DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Naturopathic Treatment for the Prevention of Cardiovascular Disease
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: OTHER: Naturopathic medicine. May include: fish oil, plant sterols, soluble fiber, cinnamon, coQ10 and exercise|OTHER: Conventional medical treatment (Atorvastatin,Fluvastatin,Lovastatin,Pravastatin,Rosuvastatin,Simvastatin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase II Clinical Trial of TQC3721 Suspension for Inhalation
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: TQC3721 suspension for inhalation|DRUG: TQC3721 suspension placebo for inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Beta Blockers Plus Intravenous Flecainide for Paroxysmal Atrial Fibrillation: a Real-world Chios Registry (BETAFLEC-CHIOS)
Status: COMPLETED
Conditions: Atrial Fibrillation|Arrhythmias, Cardiac
Interventions: DRUG: Flecainide Injectable Product
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combined and Separate Effects of Cannabis and Tobacco: Psychomotor, Subjective and Physiological Outcomes
Status: NOT_YET_RECRUITING
Conditions: Driving Under the Influence
Interventions: DRUG: Cannabis|DRUG: Tobacco|DRUG: Cannabis tobacco|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Brain Oxygenation in Newborns Due to Neuroaksial Methods
Status: NOT_YET_RECRUITING
Conditions: Cesarean Section|Pregnancy Related|Cerebral Hypoxia|Anesthesia, Regional|Oxygen Saturation
Interventions: PROCEDURE: Spinal Anesthesia|PROCEDURE: Epidural Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: OriCAR-017 Chimeric Antigen Receptor (CAR) Modified T Cells for the Treatment of R/RMM
Status: RECRUITING
Conditions: Relapsed and/or Refractory Multiple Myeloma
Interventions: BIOLOGICAL: OriCAR-017
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tucatinib Together With Pembrolizumab and Trastuzumab
Status: RECRUITING
Conditions: Breast Cancer|HER2-positive Breast Cancer
Interventions: DRUG: Tucatinib|DRUG: Pembrolizumab|DRUG: Trastuzumab|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vestibular Socket Therapy (VST) Versus Partial Extraction Therapy
Status: COMPLETED
Conditions: Dental Implants
Interventions: PROCEDURE: Class I extractions sites received immediate implants using the Vestibular Socket Therapy|PROCEDURE: class I extractions sites received immediate implants using the Partial Extraction Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of Golimumab in Patients With Active Psoriatic Arthritis
Status: COMPLETED
Conditions: Arthritis, Psoriatic
Interventions: BIOLOGICAL: golimumab|BIOLOGICAL: Placebo; golimumab|BIOLOGICAL: golimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Electronic Cigarette Withdrawal Syndrome
Status: RECRUITING
Conditions: E-cigarette Use|Withdrawal
Interventions: DRUG: Transdermal Nicotine Patch|DRUG: Placebo Nicotine Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bacterial Interference for Prevention of Catheter-Associated UTI: Geriatric Pilot Study
Status: COMPLETED
Conditions: Urinary Tract Infection
Interventions: DEVICE: E. coli 83972 coated urinary catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Pharmacokinetics, Safety, and Efficacy of Two Doses of Bimekizumab in Adolescent Study Participants With Moderate to Severe Plaque Psoriasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Moderate to Severe Plaque Psoriasis
Interventions: DRUG: bimekizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II/III Study of an Alpha-1 Proteinase Inhibitor (Kamada-API) in Individuals With Alpha-1 Antitrypsin Deficiency
Status: COMPLETED
Conditions: Alpha 1-Antitrypsin Deficiency
Interventions: DRUG: Kamada-API
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Development of a Urine-Based Point-of-Care Test for Adherence to Antiretroviral Drugs
Status: COMPLETED
Conditions: Medication Adherence|HIV
Interventions: DRUG: dolutegravir oral tablet 50mg|DRUG: emtricitabine/tenofovir alafenamide oral tablet 200mg/25mg|DRUG: tenofovir disoproxil fumarate oral tablet 300mg|DRUG: lamivudine oral tablet 300mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Epidural Steroid Injections in Post-lumbar Surgery Syndrome After Single-level Discectomy
Status: COMPLETED
Conditions: Failed Back Surgery Syndrome|Low Back Pain|Radiculopathy|Epidural Fibrosis
Interventions: PROCEDURE: Transforaminal epidural steroid injection|PROCEDURE: Caudal epidural steroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Clinical Effectiveness of a Collagen-ORC Antimicrobial Matrix in Full-Thickness, Neuropathic Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Foot Ulcer
Interventions: DEVICE: Collagen ORC Antimicrobial Matrix (CAM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conjunctival Swab vs Nasopharyngeal Swab in Patients With COVID-19
Status: UNKNOWN
Conditions: COVID-19|SARS-CoV 2
Interventions: DIAGNOSTIC_TEST: Conjunctival swab and nasopharyngeal swab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cannabioids as a New Intervention for Amphetamine Dependence
Status: WITHDRAWN
Conditions: Amphetamine Addiction
Interventions: DRUG: drug administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Randomized Double Blind Placebo Controlled Clinical Trial to Evaluate Obese and Overweight Subjects
Status: COMPLETED
Conditions: Weight Loss
Interventions: DRUG: Polyglucosamine L112|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Sirolimus and Erlotinib in Recurrent/Refractory Germ Cell Tumors
Status: TERMINATED
Conditions: Relapsed / Recurrent Germ Cell Tumors
Interventions: DRUG: Erlotinib|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Sakakibara Health Integrative Profile of Atherosclerotic-Carcinogenesis Hypothesis (SHIP-AC)
Status: COMPLETED
Conditions: Cancers|Atheroscleroses, Coronary|Atherosclerosis of Artery
Interventions: OTHER: incidece of cancers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of a Structured Clinical Assessment MIDSA, Its Feedback and Support for Change on Commitment to Care of Perpetrators of Sexual Offenses
Status: RECRUITING
Conditions: Offense, Sex
Interventions: BEHAVIORAL: MIDSA|BEHAVIORAL: Usual methods of evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: PROUD Study - Preventing Opioid Use Disorders
Status: TERMINATED
Conditions: Anesthesia|Opioid Use
Interventions: BEHAVIORAL: Guided mindfulness exercises|OTHER: Self-administered aromatherapy|DRUG: Baby aspirin|DRUG: Tylenol/Acetaminophen|DRUG: Pregabalin|DRUG: Prednisone|DRUG: Meloxicam|DRUG: Prilosec|DRUG: Tramadol|DRUG: Voltaren|DRUG: Zofran|DRUG: Pepcid|DRUG: Reglan|DRUG: Versed|DRUG: Lidocaine|DRUG: Propofol|DRUG: Ancef|DRUG: Tranexamic Acid (TXA)|DRUG: Decadron|DRUG: Bupivacaine hydrochloride|DRUG: Toradol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Gastrointestinal Health and Reducing Subclinical Inflammation in Obese Individuals
Status: COMPLETED
Conditions: Obesity|Overweight
Interventions: OTHER: Fruits and Vegetables|OTHER: Whole Grain|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Intelligent Diabetes TelemonitoRing Using Decision Support to Treat Patients on Insulin Therapy
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes Treated With Insulin
Interventions: DEVICE: Intelligent telemonitoring|DEVICE: Telemonitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Tendon Disease Using Autologous Adipose-derived Mesenchymal Stem Cells
Status: UNKNOWN
Conditions: Rotator Cuff Tear|Lateral Epicondylitis
Interventions: BIOLOGICAL: Autologous adipose-derived MSCs|DRUG: Compound betamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ultra-Short Anatomic and Conventional Cementless Stems Cementless Stems in Patients Younger Than Fifty-Five Years Old
Status: COMPLETED
Conditions: Hip Replacement, Total|Osteonecrosis of Femoral Head|Coxarthrosis
Interventions: PROCEDURE: Total hip replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Rituximab in Patients With Acute Rheumatic Fever
Status: SUSPENDED
Conditions: Rheumatic Heart Disease in Children
Interventions: DRUG: Rituximab added to standard of care treatment|DRUG: standard of care treatment alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Bone Mineral Density and Trabecular Bone Score in Patients With Ankylosing Spondylitis
Status: COMPLETED
Conditions: AS
Interventions: DEVICE: Bone Mineral Density and Trabecular Bone score
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Multicenter Selective Lymphadenectomy Trial (MSLT)
Status: COMPLETED
Conditions: Melanoma
Interventions: PROCEDURE: Sentinel Lymph Node Dissection|PROCEDURE: Complete Lymph Node Dissection|PROCEDURE: Wide Excision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DRug Use & Infections in ViEtnam - Hepatitis C (DRIVE-C)
Status: COMPLETED
Conditions: Hepatitis C|Drug Use|Viral Hepatitis C
Interventions: DRUG: Sofosbuvir 400 mg and Daclatasvir 60 mg|DRUG: Sofosbuvir 400 mg and Daclatasvir 90 mg|DRUG: Ribavirin|DRUG: Sofosbuvir and Daclatasvir for 24 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KidneyCare Immuno-optimization in Renal Allografts (KIRA)
Status: WITHDRAWN
Conditions: Kidney Transplant|Immunosuppression|Allograft
Interventions: DIAGNOSTIC_TEST: KidneyCare|DRUG: steroid|DRUG: MMF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maintenance Treatment of Multiple Myeloma (MM) After Autologous Peripheral Blood Transplant (PBSCT) Using Polyethylene Glycol alpha2B Interpheron (PEG-INTRON)
Status: UNKNOWN
Conditions: Multiple Mieloma
Interventions: DRUG: PEG-Intron sc injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Renal Stones With Frankincense (Luban)
Status: UNKNOWN
Conditions: Renal Stones
Interventions: DRUG: AKBA-Incense (3-acetyl-11-keto-ß-boswellic acid)|DRUG: Potassium Sodium Hydrogen Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of M7824 and Paclitaxel Combination as a Second-line Treatment in Patients With Recurrent/Metastatic Gastric Cancer
Status: COMPLETED
Conditions: Recurrent/Metastatic Gastric Cancer
Interventions: DRUG: M7824+paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Magnetic Resonance Imaging and Deep Learning of Joint Synovial Disease
Status: COMPLETED
Conditions: Synovial Diseases|Pigmented Villonodular Synovitis|Gout|Rheumatoid Arthritis
Interventions: DIAGNOSTIC_TEST: Synovitis diagnosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mosaic HIV-1 Envelope Trimer Immunogens Administered to People Living With HIV (PLWH) in Africa
Status: NOT_YET_RECRUITING
Conditions: HIV
Interventions: DRUG: Investigational product HIV Env Mosaic immunogens MOS1SIP, MOS2SIP, M3SIP8 and Monophosphoryl lipid A liposomes (MPLA-5) adjuvant (IM)|DRUG: : Investigational product HIV Env Mosaic immunogens MOS1SIP, MOS2SIP, M3SIP8 and Monophosphoryl lipid A liposomes (MPLA-5) adjuvant (IM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intragastric Balloon, Air Versus Fluid Filled: Randomized Prospective Study
Status: UNKNOWN
Conditions: Morbid Obesity|Weight Loss|Tolerance
Interventions: DEVICE: Air filled balloon|DEVICE: Bioenteric BIB® balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Computed Tomography Scan in Complex Chronic Total Occlusion Percutaneous Coronary Intervention;
Status: RECRUITING
Conditions: Total Occlusion of Coronary Artery
Interventions: PROCEDURE: CT scan|PROCEDURE: No CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pragmatic Open - Label Randomized Clinical Trial of FF/UMEC/VI vs Non-ellipta Usual Care ICS-LABA for Adult Participants With Uncontrolled Asthma
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: Fluticasone furoate/umeclidinium bromide/vilanterol trifenatate|DRUG: Inhaled corticosteroids/long-acting beta-2 agonists
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Efficacy and Safety of R093877 in Patients With Chronic Idiopathic Constipation
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: prucalopride|DRUG: prucalopride|DRUG: 2 mg prucalopride|DRUG: 4 mg prucalopride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of the Contura™ Catheter to Deliver Accelerated Partial Breast Irradiation to "Low-risk" Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DEVICE: Accelerated partial breast irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MATAspire: Mental Health Awareness Tailored App for Substance Prevention and Integrated Resilience Education
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use|Cannabis Use|Nicotine Use|Illicit Drug Use|Prescription Opioid Misuse
Interventions: BEHAVIORAL: MATAspire Web-app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Prospective Trial of Non-healing Diabetic Foot Ulcers Treated With Standard Care With or Without BR-AC
Status: NOT_YET_RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: OTHER: BR-AC|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of Simultaneous Boost Intensity-Modulated Radiotherapy for Locally Advanced Cervical Cancer
Status: COMPLETED
Conditions: Locally Advanced Cervical Cancer
Interventions: DRUG: Cisplatin|RADIATION: Intensity-modulated radiation therapy|PROCEDURE: Intracavitary brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Immunonutrition in Colorectal Cancer Patients Undergoing Abdominal Surgery
Status: COMPLETED
Conditions: ColoRectal Cancer
Interventions: DIETARY_SUPPLEMENT: Immunonutrition with arginine|DIETARY_SUPPLEMENT: Immunonutrition without Arginine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Medial Versus Traditional Approach to US-guided TAP Blocks for Open Inguinal Hernia Repair
Status: UNKNOWN
Conditions: Abdominal Muscles/Ultrasonography|Adult|Ambulatory Surgical Procedures|Anesthetics, Local/Administration & Dosage|Ropivacaine/Administration & Dosage|Ropivacaine/Analogs & Derivatives|Hernia, Inguinal/Surgery|Humans|Nerve Block/Methods|Pain Measurement/Methods|Pain, Postoperative/Prevention & Control|Ultrasonography, Interventional
Interventions: PROCEDURE: TAP block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Assessing Safety, Immunogenicity and LDLc -Lowering Activity of 2 PCSK9 Targeting AFFITOPE Vaccines in Healthy Subjects
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: BIOLOGICAL: AFFITOPE® AT04A+adjuvant|BIOLOGICAL: AFFITOPE® AT06A+adjuvant|BIOLOGICAL: Adjuvant without active component
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of Two Newly Developed Tablet Formulations (TF2 and iFF)Compared to BI 1060469 TF1 Formulation, Following Oral Administration (Low and High Dose)in Healthy Female Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1060469, iFF, Test|DRUG: BI 1060469, iFF, Test|DRUG: BI 1060469, TF1, Reference|DRUG: BI 1060469, TF2, Test|DRUG: BI 1060469, TF2, Test|DRUG: BI 1060469, iFF, Test|DRUG: BI 1060469, TF1, Reference|DRUG: BI 1060469, iFF, Test|DRUG: BI 1060469, iFF, Test|DRUG: BI 1060469, TF1, Reference|DRUG: BI 1060469, TF2, Test|DRUG: BI 1060469, TF1, Reference|DRUG: BI 1060469, TF1, Reference|DRUG: BI 1060469, TF2, Test|DRUG: BI 1060469, TF2, Test|DRUG: BI 1060469, iFF, Test|DRUG: BI 1060469, TF2, Test|DRUG: BI 1060469, TF1, Reference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Affect of a Continuous Epidural Infusion of Clonidine During Labour. Prospective Double Blind Randomized Trial
Status: COMPLETED
Conditions: Normal Pregnancy
Interventions: DRUG: Clonidine|DRUG: Levobupivacaine|DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol
Status: UNKNOWN
Conditions: Otitis Media
Interventions: DRUG: 0.1% Pazufloxacin Mesilate Ear Drops|DRUG: 0.3% Pazufloxacin Mesilate Ear Drops|DRUG: 0.5% Pazufloxacin Mesilate Ear Drops|DRUG: Pazufloxacin mesilate injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Immediate Postoperative Delirium (IPD) in Adult Patients: Incidence and Etiologic Factors
Status: COMPLETED
Conditions: Delirium|Anesthesia; Adverse Effect
Interventions: PROCEDURE: Types of Anesthesia|PROCEDURE: Access of Surgery|OTHER: Comorbidities|DRUG: Preoperative Medication|DIAGNOSTIC_TEST: Routine blood test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Advanced Magnetic Resonance Imaging (MRI) in Men With Suspected Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: TRUS Biopsy|PROCEDURE: TRUS/FUSION Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Safety Study of Coronary CTA for the Diagnosis of Acute Coronary Syndrome in the Emergency Room
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Coronary Artery Disease|Cardiac Death|Myocardial Infarction
Interventions: RADIATION: computed coronary angiography|PROCEDURE: Exercise stress echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparing Three Dimension Laparoscopic Versus Open Surgery for Perihiliar Cholangiocarcinoma
Status: UNKNOWN
Conditions: Cholangiocarcinoma, Perihilar|Surgery
Interventions: PROCEDURE: Three dimensional laparoscopic resection for pCCA|PROCEDURE: Open resection for pCCA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin C on Acute and Chronic Post Mastectomy Pain
Status: RECRUITING
Conditions: Vitamin C|Post-mastectomy Pain Syndrome
Interventions: DRUG: vitamin C group|OTHER: placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sunitinib Malate in Treating Patients With Iodine-Refractory Recurrent or Metastatic Thyroid Cancer
Status: COMPLETED
Conditions: Recurrent Thyroid Cancer|Stage IVA Follicular Thyroid Cancer|Stage IVA Papillary Thyroid Cancer|Stage IVB Follicular Thyroid Cancer|Stage IVB Papillary Thyroid Cancer|Stage IVC Follicular Thyroid Cancer|Stage IVC Papillary Thyroid Cancer|Thyroid Gland Medullary Carcinoma
Interventions: DRUG: sunitinib malate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shocking Therapy for Chronic Pelvic Pain Syndrome
Status: UNKNOWN
Conditions: Chronic Prostatitis With Chronic Pelvic Pain Syndrome
Interventions: DEVICE: Shock wave therapy|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Community Development and Nutrition Education in Banke District, Nepal: Effect on Child Health and Growth
Status: COMPLETED
Conditions: Malnutrition
Interventions: BEHAVIORAL: Training Plus|BEHAVIORAL: Training Only|BEHAVIORAL: No Inputs then Community development and training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety of Minimally Invasive Surgery Using Endoscopic Stapler in Early Stage Cervical Cancer Patients (SOLUTION)
Status: RECRUITING
Conditions: Cervical Cancer|Cervical Cancer Stage IB1|Minimally Invasive Surgery
Interventions: PROCEDURE: Minimally invasive surgery using endoscopic stapler
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Discharge Smoking Cessation Strategies: Helping HAND 4
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Transitional Tobacco Care Management (TTCM)|BEHAVIORAL: eReferral to State Tobacco Quitline (QL)|DRUG: Nicotine replacement therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Benefit of Amlodipine in HRT Cycle for Frozen Embryo Transfer in the Correction of Uterine Pulsatility Index
Status: WITHDRAWN
Conditions: Frozen Embryo Transfer
Interventions: DRUG: Amlodipine 5mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT