pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Horizontal Ridge Reconstruction of Atrophic Anterior Maxillary Ridges Using Customized Xenograft Bone Shell With 1 :1 Mixture of Autogenous and Xenograft Bone Particulate
Status: UNKNOWN
Conditions: Atrophic Anterior Maxillary Ridges
Interventions: PROCEDURE: Atrophic Anterior Maxillary Ridges
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of the Ocular Surface With Preservative-Free Lubricants in Patients With Dry Eye
Status: RECRUITING
Conditions: Dry Eye Disease
Interventions: DRUG: Preservative-free sterile ophthalmic solution, with 0.3% propylene glycol and 0.4% polyethylene glycol (400)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of Bendamustine, Lenalidomide and Rituximab in Chronic Lymphocytic Leukemia (CLL) and Non-Hodgkin's Lymphoma (NHL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Non-Hodgkin's Lymphoma
Interventions: DRUG: bendamustine and lenalidomide|DRUG: BL-NHL|DRUG: BLR-CLL|DRUG: BLR-NHL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Antibacterial Mouthwash on Muscle Function in Healthy Young Men and Women
Status: COMPLETED
Conditions: Quadriceps Muscle
Interventions: DEVICE: Cepacol|DEVICE: Tom's Natural Mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Safety and Efficacy of SK-0503 for Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalency Study of Mycophenolate Mofetil 250 mg Capsules Under Fasted Conditions
Status: COMPLETED
Conditions: Prophylaxis of Organ Rejection
Interventions: DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Anti-inflammatory Effect of Anti-hypertensive Treatment in Patients With Small AAA's and Mild Hypertension
Status: TERMINATED
Conditions: Hypertension|Abdominal Aortic Aneurysm
Interventions: DRUG: Aliskiren|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BCG With or Without Mitomycin in Treating Patients With Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: BIOLOGICAL: BCG vaccine|DRUG: mitomycin C|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: eMOTION: Examining Affective Mechanisms in Physical Activity Engagement
Status: RECRUITING
Conditions: Physical Inactivity|Overweight or Obesity|Cancer
Interventions: BEHAVIORAL: Physical Activity Goals mHealth Intervention|BEHAVIORAL: TYPE/CONTEXT enhancement|BEHAVIORAL: SAVOR enhancement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Negative Pressure Wound Therapy on Free Muscle Flaps
Status: COMPLETED
Conditions: Negative-Pressure Wound Therapy|Edema|Free Flap|Microcirculation|Macrocirculation
Interventions: DEVICE: V.A.C. UltraTM (KCI®,San Antonio, Texas, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of a Bioabsorbable Medical Device for the Prevention of Postoperative Intra-uterine Adhesions.
Status: WITHDRAWN
Conditions: Infertility|Abortion, Spontaneous|Embryo Implantation, Delayed
Interventions: BIOLOGICAL: Hysteroscopy + endometrial biopsy|OTHER: Telephone call|BIOLOGICAL: Resection + endometrial biopsy|BIOLOGICAL: Follow-up hysteroscopy + endometrial biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vaginal Misoprostol Before IUD Insertion in Women With Cesarean Scar
Status: COMPLETED
Conditions: Contraceptive Device; Complications
Interventions: DRUG: Misoprostol|DEVICE: Intrauterine contraceptive device IUCD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of Andecaliximab in Participants With Moderately to Severely Active Crohn's Disease
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: DRUG: Andecaliximab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics of ACT-541468 in Subjects With Mild, Moderate, and Severe Hepatic Impairment
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: ACT-541468 25 mg|DRUG: ACT-541468 25 mg (or 10 mg depending on interim results)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prevalence of Chronic Pain and Its Risk Factors After a Surgical Intensive Care Unit Stay. Prospective Observational Cohort
Status: COMPLETED
Conditions: Pain, Chronic|Critically Ill|Opioid-Related Disorders
Interventions: OTHER: surveys
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety of Inhaled Preprandial Human Insulin in Subjects With Diabetes and Asthma
Status: TERMINATED
Conditions: Diabetes|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2|Asthma
Interventions: DRUG: insulin aspart|DRUG: inhaled human insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Plant-Based Diet on Insulin Requirements and Obesity Markers in Obese Adults With T2DM
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Insulin Resistance|Obesity|Nutritional and Metabolic Disease
Interventions: BEHAVIORAL: DASH|BEHAVIORAL: Whole-Food, Plant-Based
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The PREVENT AGITATION Trial II - Children ≤1 Year
Status: RECRUITING
Conditions: Emergence Delirium
Interventions: DRUG: Clonidine|DRUG: Sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Safety of Intravenous Artesunate
Status: COMPLETED
Conditions: Malaria|Malaria, Cerebral
Interventions: DRUG: Intravenous Artesunate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolomics of Intraoperative Saline and Balanced Crystalloid Infusion
Status: COMPLETED
Conditions: Metabolomics
Interventions: DRUG: Saline|DRUG: Balanced crystalloid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Strategies to Prevent Transcatheter Heart Valve Dysfunction in Low Risk Transcatheter Aortic Valve Replacement
Status: UNKNOWN
Conditions: Aortic Stenosis
Interventions: DEVICE: TAVR|OTHER: Warfarin plus Aspirin|OTHER: Aspirin Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Clinical Usage of a Free Gingival Graft Combined With Frenotomy in Patients With High Frenal Attachment
Status: NOT_YET_RECRUITING
Conditions: High Frenum Attachment|Free Gingival Graft
Interventions: BIOLOGICAL: Combining free gingival graft with frenotomy procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Hypoxia and Balance Control
Status: COMPLETED
Conditions: Intermittent Hypoxia|Normoxia
Interventions: BEHAVIORAL: Intermittent Hypoxia|BEHAVIORAL: Normoxia (sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PROMMO Trial: Oral Misoprostol vs IV Oxytocin
Status: RECRUITING
Conditions: Premature Rupture of Membrane|Induction of Labor Affected Fetus / Newborn
Interventions: DRUG: Misoprostol Oral Product|DRUG: Intravenous Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Impact of CD34+ Cell Dose on Absolute Lymphocyte Count Following High-Dose Therapy and Autologous Stem Cell Transplantation for Relapsed and Refractory Diffuse Large B-cell Lymphoma (DLBCL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Diffuse Large B-cell Lymphoma (DLBCL)|Relapsed Diffuse Large B-cell Lymphoma (DLBCL)|Refractory Diffuse Large B-cell Lymphoma (DLBCL)
Interventions: PROCEDURE: leukapheresis|DRUG: Plerixafor|DRUG: carmustine, etoposide, cytarabine, melphalan|PROCEDURE: Autologous Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Paliperidone Extended Release (ER) Among Thai Schizophrenia Participants
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Paliperidone extended release (ER)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride
Status: COMPLETED
Conditions: Orthostatic Hypotension|Spinal Cord Injury
Interventions: DRUG: Midodrine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biological Therapy and Chemotherapy in Treating Patients With Metastatic Kidney Cancer or Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Kidney Cancer
Interventions: BIOLOGICAL: recombinant interferon alfa|BIOLOGICAL: sargramostim|BIOLOGICAL: therapeutic autologous lymphocytes|DRUG: fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Exploratory Study of ART-123 for the Prevention of Cancer Treatment Related Symptoms in Patients With Postoperative Stage II / III Colon Cancer
Status: COMPLETED
Conditions: Postoperative Stage II/III Colon Cancer
Interventions: DRUG: ART-123 (3-day ART)|DRUG: ART-123 (1-day ART)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Safety and Efficacy Study of Remibrutinib in the Treatment of CSU in Japanese Adults Inadequately Controlled by H1-antihistamines
Status: COMPLETED
Conditions: Chronic Spontaneous Urticaria
Interventions: DRUG: LOU064
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prediction of Patient Deterioration Using Machine Learning
Status: UNKNOWN
Conditions: Infection|Heart Failure|Chronic Obstructive Pulmonary Disease|Asthma|Gout Flare|Chronic Kidney Diseases|Hypertensive Urgency|Atrial Fibrillation Rapid|Anticoagulants; Increased
Interventions: OTHER: Traditional vital sign alarms versus the BioVitals Index vs the National Early Warning Score 2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Solaris DE Endoprosthesis for the Treatment of AV Access Stenosis or Occlusion
Status: RECRUITING
Conditions: Venous Stenosis|Venous Occlusion|Chronic Renal Failure
Interventions: DEVICE: Solaris DE|DEVICE: PTA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laminar LAAX Pivotal IDE Study
Status: ENROLLING_BY_INVITATION
Conditions: Non-valvular Atrial Fibrillation|Stroke
Interventions: DEVICE: Experimental: Laminar Left Atrial Appendage Closure System|DEVICE: Active Comparator: WATCHMAN / Amulet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Tracheobronchial Reconstruction Using Bioengineered Aortic Matrices
Status: UNKNOWN
Conditions: Trachea Diseases|Tracheal Stenosis|Lung Cancer|Tuberculosis; Tracheitis|Airway Disease
Interventions: PROCEDURE: Cryopreserved aorta
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effectiveness of Cardiac Rehabilitation (Rehab) for Acute Decompensated Heart Failure Patients on 6 Minute Walk Test and Quality of Life
Status: TERMINATED
Conditions: Heart Failure
Interventions: OTHER: Cardiac rehab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence and Wear Study of Mylan Fentanyl Transdermal System 25 µg/h and Mylan Fentanyl Transdermal System
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Fentanyl Transdermal System 25 mcg/h + Bioclusive Overlay|DRUG: Fentanyl Transdermal System 25 mcg/h
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: An Enhanced Adherence Support Programme for Highly Active Antiretroviral Therapy (HAART)
Status: COMPLETED
Conditions: HIV Infections
Interventions: BEHAVIORAL: Enhanced adherence support|BEHAVIORAL: Standard adherence support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluating the Efficacy of a Group Social Skills Intervention
Status: COMPLETED
Conditions: Brain Tumours
Interventions: BEHAVIORAL: Structured social skills training program, SSIP|BEHAVIORAL: CG - social skills activities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Complete Decongestive Therapy Versus Compression Bandaging in Advanced Secondary Lymphedema
Status: COMPLETED
Conditions: Edema Due to Obstruction of Lymph Vessels or Excision of Lymph Nodes
Interventions: OTHER: Physiotherapy Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carbon Monoxide Measurement to Screen for Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Anemia
Interventions: DEVICE: End-tidal Carbon Monoxide Subjects|DEVICE: End-tidal Carbon Monoxide Controls
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Exercise Prehabilitation in Patients With Head and Neck Squamous-cell Carcinoma: The FIT4TREAT Trial
Status: RECRUITING
Conditions: Head and Neck Neoplasms
Interventions: OTHER: Prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cyclophosphamide Plus Bone Marrow Transplantation in Treating Patients With Hematologic Cancer
Status: COMPLETED
Conditions: Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases
Interventions: BIOLOGICAL: filgrastim|DRUG: cyclophosphamide|DRUG: fludarabine phosphate|DRUG: mycophenolate mofetil|DRUG: tacrolimus|PROCEDURE: allogeneic bone marrow transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: cisplatin|DRUG: irinotecan hydrochloride|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Linguistic Validation of the Childhood Bladder and Bowel Dysfunction Questionnaire (CBBDQ) for 5-12 Years Old in Korean
Status: ACTIVE_NOT_RECRUITING
Conditions: Dysfunctional Voiding|Bladder Dysfunction|Bowel Dysfunction|Pediatric Urology
Interventions: OTHER: Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MiraLAX Versus Placebo to Prevent Constipation Following Urogynecologic Surgery
Status: COMPLETED
Conditions: Post Procedural Constipation
Interventions: DRUG: MiraLax|DRUG: Placebo|DRUG: Rescue Laxative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Patient Satisfaction After Root Coverage Using VISTA Technique Compared to MCAF Technique With PRF.
Status: UNKNOWN
Conditions: Gingival Recession
Interventions: PROCEDURE: VISTA Technique|PROCEDURE: modified coronally advanced flap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thalidomide and Temozolomide or Camptothecin-11 (CPT-11) in Patients With Gliomas
Status: COMPLETED
Conditions: Glioblastoma Multiforme|Glioma
Interventions: DRUG: Thalidomide|DRUG: CPT-11|PROCEDURE: MRI Scan|PROCEDURE: Quantitative Sensory Tests (QST)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b Study of Atezolizumab in Combination With Vemurafenib or Vemurafenib Plus Cobimetinib in Participants With BRAFV600-Mutation Positive Metastatic Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: DRUG: Atezolizumab|DRUG: Cobimetinib|DRUG: Vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimum Effective Dose (MED) & Epidural Bupivacaine
Status: UNKNOWN
Conditions: Pregnancy|Labour|Primigravida Labour|Epidural Block
Interventions: DRUG: 0.1% bupivacaine|DRUG: 0.075% bupivacaine|DRUG: 40 µg fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intramuscular Naloxone 0.4mg. in Prophylaxis of Intrathecal Morphine Induced Pruritus After Cesarean Section
Status: COMPLETED
Conditions: Morphine Adverse Reaction
Interventions: DRUG: naloxone|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Reduced Toxicity Myeloablative Conditioning Regimen for Cord Blood Transplantation in Pediatric AML
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Fludarabine, Busulfan, Thymoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS)
Status: RECRUITING
Conditions: Cancer|Malignancies Multiple|Malignant Solid Tumor|Cancer, Therapy-Related|Molecular Sequence Variation|Genetic Alteration|Gene Fusion|Receptor Tyrosine Kinase Gene Mutation|RTK Family Gene Mutation|Ras (Kras or Nras) Gene Mutation
Interventions: DRUG: Cancer treatment with tyrosine kinase inhibitors (TKIs) or other molecularly targeted therapeutic agents.|OTHER: Patient-reported outcomes (PROs)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Laser Treatment for Facial and Neck Rejuvenation
Status: NOT_YET_RECRUITING
Conditions: Face Rejuvenation|Neck Rejuvenation
Interventions: OTHER: CeraVe|OTHER: CeraVe and Calecim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: AMG 509|DRUG: Abiraterone|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The ROVO Study: Radial Optic Neurotomy for CVO
Status: COMPLETED
Conditions: Central Retinal Vein Occlusion
Interventions: DRUG: Intravitreal Triamcinolone|PROCEDURE: Radial Optic Neurotomy|OTHER: Placebo - Sham Intravitreal Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Single Patient Protocol for Donor HCV-positive to Recipient HCV-negative Kidney Transplant in a Patient at Risk for Loss of Dialysis Access
Status: WITHDRAWN
Conditions: End Stage Renal Disease|Chronic Hepatitis c
Interventions: DRUG: Glecaprevir / Pibrentasvir Oral Tablet [Mavyret]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Toremifene Citrate for Prevention of Bone Fractures in Men With Prostate Cancer on Androgen Deprivation Therapy
Status: COMPLETED
Conditions: Prostate Cancer|Osteoporosis|Fractures
Interventions: DRUG: Toremifene Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Post-marketing Surveillance of HIV-infected Patients With Chronic Hepatitis C Treated With PegIntron Pen and Rebetol (Study P04584)
Status: COMPLETED
Conditions: Chronic Hepatitis C|Hepatitis C|HIV Infections
Interventions: BIOLOGICAL: PEG-IFN alfa-2b|DRUG: RBV
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Topical Morphine for Stomatitis-related Pain Induced by Chemotherapy
Status: COMPLETED
Conditions: Pain|Mucositis
Interventions: DRUG: morphine solution for injection|DRUG: Placebo|DRUG: morphine mouthwash|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy, Safety and Tolerability of ABT-SLV187 Monotherapy in Subjects With Advanced Parkinson's Disease (PD) and Persistent Motor Complications, Despite Optimized Treatment With Available Anti-Parkinsonian Medications
Status: COMPLETED
Conditions: Advanced Parkinson's Disease
Interventions: DRUG: Levodopa-carbidopa intestinal gel|DEVICE: CADD-Legacy® 1400 ambulatory infusion pump|DEVICE: PEG tube|DEVICE: J-tube
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dendritic Cell Vaccine in HIV-1 Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: Dendritic cell vaccine|BIOLOGICAL: non pulsed dendritic cell untreated patients|BIOLOGICAL: pulsed dendritic cell vaccine|BIOLOGICAL: dendritic cell vaccine|BIOLOGICAL: non pulsed dendritic cell vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of 10 Minute-prewarming on Core Body Temperature During Gynecologic Laparoscopic Surgery Under General Anesthesia
Status: COMPLETED
Conditions: Hypothermia; Anesthesia
Interventions: DEVICE: Prewarming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Use of Presepsin as a Marker for Immunotherapy Administration in Pneumonia
Status: COMPLETED
Conditions: Community-acquired Pneumonia|Hospital-acquired Pneumonia
Interventions: DRUG: Anakinra Prefilled Syringe|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Cisplatin and Pemetrexed in Combination With Panobinostat in Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors|Non-Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: Panobinostat, Cisplatin, Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Supplementation of Glutamine on Gastric Cancer Patients After Gastrectomy
Status: RECRUITING
Conditions: Gastric Cancer|Immunonutrition|Gastrostomy
Interventions: DIETARY_SUPPLEMENT: oral glutamine|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tissue Elastography Assessement and Cuteous and Cubcutaneous Thickness Measurement Following Manual Lymph Drainage in Legs With Lymphedema
Status: COMPLETED
Conditions: Lymphedema|Lower Limb Lymphedema
Interventions: OTHER: Ultrasonography / Ultrasound elastography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hypothermic Oxygenated Perfusion (HOPE) of Human Liver Grafts
Status: COMPLETED
Conditions: Hepatocellular Injury
Interventions: DEVICE: Hypothermic oxygenated perfusion (HOPE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biochemical Response to Interferon-Gamma in Subjects With Specific Gene Mutation in Chronic Granulomatous Disease
Status: TERMINATED
Conditions: IFN-Gamma Therapy|CGD Gene Mutation|CGD Response to IFNg|CGD - Chronic Granulomatous Disease|Immunodeficiency Disease
Interventions: DRUG: IFN-gamma
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pacing Activity Self-management for Patients With Chronic Fatigue Syndrome
Status: COMPLETED
Conditions: Chronic Fatigue Syndrome
Interventions: BEHAVIORAL: Pacing|BEHAVIORAL: relaxation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of EPSW Plus HILT on Carpal Tunnel Syndrome Post Burn Injury
Status: RECRUITING
Conditions: Burn Injury
Interventions: DEVICE: Extracorporeal Shock Wave Therapy.|DEVICE: High Intensity Laser Therapy|OTHER: Traditional Physical Therapy Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Endometrial Thickness Among Adolescent and Young Adult Patients on Estrogen Replacement Therapy Using Daily Oral Micronized Progesterone Versus the Etonogestrel Implant.
Status: NOT_YET_RECRUITING
Conditions: Primary Ovarian Insufficiency|Hypogonadotropic Hypogonadism|Hormone Replacement Therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability and Efficacy of Vaginal Suppositories for Treatment of the Endometriosis
Status: WITHDRAWN
Conditions: Endometriosis|Endometriosis Ovary|Endometriosis Externa|Endometriosis, Rectum
Interventions: BIOLOGICAL: Linifanib|DRUG: BIBW2992|DRUG: Axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Efficacy of Channa Striata in Stabilizing eNOS in Patients With Septic.
Status: COMPLETED
Conditions: Sepsis
Interventions: DIETARY_SUPPLEMENT: Albumin Channa Striata Extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neurobiology and Pharmacokinets of Acute MDMA Administration
Status: COMPLETED
Conditions: Substance-Related Disorders
Interventions: DRUG: MDMA|DRUG: (+/-)3,4-methylenedioxymethamphetamine Hydrochloride, MDMA HCI Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: |Primary Purpose: OTHER
Clinical trial: Alcohol Locks for the Prevention of Tunneled Catheter-related Infections
Status: COMPLETED
Conditions: Bacteremia
Interventions: PROCEDURE: Alcohol-lock|DRUG: placebo-lock
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Controlling Hypertension in Diabetes- Feasibility Study
Status: COMPLETED
Conditions: Type 2 Diabetes|Hypertension|Hyperlipidemia
Interventions: BEHAVIORAL: home health/primary care collaboration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bedside Monitoring of Cerebral Energy State During the Peri-cardiac Arrest Period
Status: COMPLETED
Conditions: Cardiac Arrest|Neurological Complication|Post-Cardiorespiratory Arrest Coma
Interventions: DIAGNOSTIC_TEST: Low MAP|DIAGNOSTIC_TEST: High MAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Mission is Remission®: How Can a Disease Self-management Website Change Care?
Status: TERMINATED
Conditions: Pediatric Crohn's Disease|Pediatric Ulcerative Colitis
Interventions: BEHAVIORAL: Mission is Remission®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigation of Efficacy and Safety of Three Dose Levels of Subcutaneous Semaglutide Once Daily Versus Placebo in Subjects With Non-alcoholic Steatohepatitis.
Status: COMPLETED
Conditions: Hepatobiliary Disorders|Non-alcoholic Steatohepatitis
Interventions: DRUG: Semaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of a Mock MRI Scanner for Reducing the Use of Anesthesia in Children Undergoing Clinical MRI Scans
Status: UNKNOWN
Conditions: Magnetic Resonance Imaging
Interventions: BEHAVIORAL: Mock MRI scanner|BEHAVIORAL: Preparation materials|BEHAVIORAL: Child Life Specialist preparation|BEHAVIORAL: Review Preparation Materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Comparison of Prophylactic Antibacterial Efficacy of Besivance vs. VIGAMOX Prior to Cataract Surgery
Status: COMPLETED
Conditions: Cataracts
Interventions: DRUG: Moxifloxacin Ophthalmic|DRUG: Besifloxacin Ophthalmic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal Treatment Strategy for Cancer Cachexia
Status: TERMINATED
Conditions: Advanced Cancer|Cachexia
Interventions: BEHAVIORAL: Graded Resistance Training|BEHAVIORAL: Aerobic Exercise|DRUG: Melatonin|DIETARY_SUPPLEMENT: Juven|DRUG: Atenolol|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Innovative Smart T-shirt Capable to Monitor ECG Signal and Related Parameters Through the Comparison With a Holter ECG and a Smartwatch
Status: RECRUITING
Conditions: Cardiac Arrhythmias
Interventions: DEVICE: Smart t-shirt|DEVICE: ECG Holter|DEVICE: Smartwatch
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Effectiveness of A-dmDT390-bisFv(UCHT1) Fusion Protein in Subjects With Mycosis Fungoides
Status: UNKNOWN
Conditions: Mycosis Fungoides
Interventions: BIOLOGICAL: A-dmDT390-bisFv(UCHT1)|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen Therapy Can Improve Cognitive Deficits Post Low Grade Glioma Removal Surgery
Status: UNKNOWN
Conditions: Post Low Grade Glioma Surgery|Cognitive Deficits
Interventions: BIOLOGICAL: HBOT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sildenafil for the Treatment of Lymphatic Malformations
Status: COMPLETED
Conditions: Lymphatic Malformations|Lymphatic Diseases
Interventions: DRUG: Sildenafil 20 mg tablets|OTHER: Placebo tablets (resembling Revatio)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Development and Application of Comprehensive Intervention Techniques for Adolescent Depression
Status: RECRUITING
Conditions: Depressive Disorder|Adolescent
Interventions: DRUG: Escitalopram|OTHER: Interpersonal Psychotherapy for Adolescent|OTHER: Escitalopram combined with psychotherapy|OTHER: Escitalopram combined with rTMS|DRUG: Escitalopram combined with sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ending Tobacco Use Through Interactive Tailored Messaging for Cambodian People Living With HIV/AIDS
Status: RECRUITING
Conditions: Smoking Cessation|HIV
Interventions: BEHAVIORAL: Smartphone-delivered Automated Messaging|DRUG: Nicotine patch|BEHAVIORAL: Brief Advice to Quit and Smoking Cessation Self Help Materials|BEHAVIORAL: Diet Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: An Extension Study to Evaluate Casimersen or Golodirsen in Patients With Duchenne Muscular Dystrophy
Status: TERMINATED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: Casimersen|DRUG: Golodirsen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Adipose Mesenchymal Stem Cell Transplantation in the Treatment of Patients With Hemifacial Spasm
Status: UNKNOWN
Conditions: Injury of Facial Nerve, Unspecified Side, Initial Encounter
Interventions: BIOLOGICAL: Autologous adipose stem cell therapy|DRUG: Mecobalamin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Camrelizumab Combined With Apatinib Mesylate Tablets and Nab-paclitaxel in the Second-line Treatment of Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Locally Advanced or Metastatic Gastric Adenocarcinoma
Interventions: DRUG: Camrelizumab|DRUG: Apatinib Mesylate|DRUG: nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluoride Application on Preventing and Arresting Root Caries in Fluoridated and Non-fluoridated Areas
Status: COMPLETED
Conditions: Dental Caries
Interventions: OTHER: water as placebo|DRUG: silver diammine fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Early Use of Long-acting Tacrolimus in Lung Transplant Recipients
Status: ENROLLING_BY_INVITATION
Conditions: Lung Transplant; Complications
Interventions: DRUG: Tacrolimus Extended Release Oral Tablet [Envarsus]|DRUG: Tacrolimus|DRUG: Mycophenolate Mofetil Hydrochloride|DRUG: Prednisone|DRUG: Azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Second Generation LMA Versus Endotracheal Tube in Obese Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Obese|Endotracheal Tube|Laryngeal Mask Airway
Interventions: DEVICE: Second-Generation Laryngeal Mask Airway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: BRAF V600E Mutations In Papillary Thyroid Carcinoma
Status: UNKNOWN
Conditions: Papillary Thyroid Carcinoma
Interventions: GENETIC: BRAF V600E POSITIVITY
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bicalutamide and Raloxifene in Treating Patients With Metastatic or Hormone-Refractory Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Adenocarcinoma of the Prostate|Hormone-resistant Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: bicalutamide|DRUG: raloxifene|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UMCC 9901: Phase II Study of Tailored-Dose Docetaxel + Trastuzumab in Her-2 Positive Metastatic Breast Cancer
Status: COMPLETED
Conditions: HER-2 Positive Metastatic Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: Trastuzumab|PROCEDURE: Erythromycin Breath Test (ERMBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Blood and Urine Kidney Injury Markers to Facilitate Early Detection of Renal Adverse Drug Events in Pediatric Cancer Patients Treated With Nephrotoxic Chemotherapy
Status: COMPLETED
Conditions: Kidney Impairment
Interventions: OTHER: blood test for renal biomarkers|OTHER: urine test for renal biomarkers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Evaluation of a New Galyfilcon A Lens Prototype and Enfilcon A Lens
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: galyfilcon A prototype lens|DEVICE: enfilcon A lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders
Status: RECRUITING
Conditions: Chronic Kidney Disease|Acute Myeloid Leukemia (AML)|Acute Lymphoblastic Leukemia (ALL)|Chronic Myelogenous Leukemia (CML)|Chronic Lymphocytic Leukemia (CLL)|Non-Hodgkin's Lymphoma (NHL)|Hodgkin Disease|Multiple Myeloma|Myelodysplastic Syndrome (MDS)|Aplastic Anemia|AL Amyloidosis|Diamond Blackfan Anemia|Myelofibrosis|Myeloproliferative Disease|Sickle Cell Anemia|Autoimmune Diseases|Thalassemia
Interventions: PROCEDURE: Haploidentical Bone Marrow/Kidney
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction
Status: RECRUITING
Conditions: Congestive Heart Failure|Heart Failure, Systolic|Heart Failure|HFrEF - Heart Failure With Reduced Ejection Fraction
Interventions: BIOLOGICAL: SRD-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compare the Safety and Efficacy of Genoss® DCB and SeQuent® Please NEO in Korean Patients With Coronary De Novo Lesions
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: GENOSS® DCB|DEVICE: SeQuent® Please NEO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Varenicline Augmentation of Patch Outcomes in Heavy Drinkers' Smoking Cessation
Status: COMPLETED
Conditions: Smoking Cessation|Alcohol Drinking
Interventions: DRUG: Chantix|BEHAVIORAL: Behavioral Counseling Sessions|DRUG: NicodermCQ|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dapagliflozin In Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Dapagliflozin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Randomized Comparison of HDAC vs AD in the Induction Chemothrapy for AML.
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: High dose Cytarabine|DRUG: Cytarabine|DRUG: Hign dose Daunorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Ablation Followed By Hepatic Artery Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver
Status: COMPLETED
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: DRUG: Floxuridine|DRUG: Fluorouracil (5-FU)|PROCEDURE: Conventional surgery|PROCEDURE: Radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: B-Lymphocyte Immunotherapy in Islet Transplantation
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus
Interventions: BIOLOGICAL: Allogeneic Pancreatic Islet Cells|BIOLOGICAL: Antithymocyte globulin|BIOLOGICAL: Daclizumab|BIOLOGICAL: Rituximab|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ayurveda for Flu Like Illness During Covid-19 Outbreak
Status: COMPLETED
Conditions: Flu Like Illness
Interventions: DIETARY_SUPPLEMENT: Ayurveda|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Reparel Knee Sleeve vs. TED Hose for Post-op Swelling, Pain and Range of Motion After Total Knee Replacement
Status: RECRUITING
Conditions: Osteoarthritis Knees Both
Interventions: DEVICE: Non-compressive Bioactive Garment|DEVICE: thrombo-embolic deterrent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplant for Autobrewery Syndrome
Status: NOT_YET_RECRUITING
Conditions: Auto-Brewery Syndrome|Gut Fermentation Syndrome
Interventions: BIOLOGICAL: Fecal microbiota transplantation capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Arm, Single Centered Phase II Trial on the Combination of Adebrelimab, Surufatinib and Irinotecan Liposome-based HAIC in Advanced iCC
Status: NOT_YET_RECRUITING
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DRUG: Adebrelimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arthroscopic Rotator Cuff Repair With Synovectomy
Status: COMPLETED
Conditions: Rotator Cuff Tears
Interventions: OTHER: Arthroscopic rotator cuff repair without synovectomy|OTHER: Arthroscopic rotator cuff repair with synovectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Combination of Electrical Stimulation and Dysport® in Myofascial Pain Syndrome.
Status: COMPLETED
Conditions: Myofascial Pain Syndromes
Interventions: BIOLOGICAL: Botulinum toxin type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Acupoint Sticking in Summer to Treat Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: Magnetic stickers|DEVICE: Sham magnetic stickers|DRUG: Chinese herbal medicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: WallFlex Esophageal Fully Covered (FC) Benign Anastomotic Stricture
Status: COMPLETED
Conditions: Refractory Anastomotic Esophageal Strictures
Interventions: DEVICE: WallFlex Esophageal RX Fully Covered Stent|DEVICE: Esophageal Bougie Dilator Per Investigator preference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Assessing Long Term USe of PCSK9 Inhibition in Subjects With Genetic LDL Disorders
Status: COMPLETED
Conditions: Severe Familial Hypercholesterolemia
Interventions: BIOLOGICAL: Evolocumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-POEM GERD in Patients Undergoing Conventional Versus Oblique Fibers Sparing Posterior Myotomy for Achalasia Cardia
Status: COMPLETED
Conditions: GERD
Interventions: PROCEDURE: Per-oral endoscopic myotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PK & Safety Study of Xeruborbactam Oral Prodrug Combined With Ceftibuten in Participants With Renal Impairment
Status: NOT_YET_RECRUITING
Conditions: Bacterial Infections
Interventions: DRUG: Xeruborbactam Oral Prodrug|DRUG: Ceftibuten
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT