pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Increasing the Use of an Anti-snoring Mouth Guard (Mandibular Advancement Appliance) to Prevent Upper Airway Collapse During Sleep in Patients With Obstructive Sleep Apnoea.
Status: RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: BEHAVIORAL: Behaviour change Intervention Based on Health Action Process Approach Model|DEVICE: Mandibular Advancement Appliance (MAA) or Anti-snoring mouth guard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2b Study to Evaluate Rezpegaldesleukin (Rezpeg) in the Treatment of Severe to Very Severe Alopecia Areata in Adult Patients (Rezolve AA)
Status: RECRUITING
Conditions: Alopecia Areata
Interventions: DRUG: Rezpegaldesleukin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Various Taping Techniques in Lateral Epicondylitis on Functional and Ultrasonographic Outcomes
Status: COMPLETED
Conditions: Tennis Elbow
Interventions: OTHER: Strengthening exercises|OTHER: Intensive Physioytherapy|DEVICE: Kinesio taping|DEVICE: Athletic taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of TECAR Therapy in Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis|Energy Transfer Capacitative and Resistive Therapy
Interventions: DEVICE: TECAR|DEVICE: conventional physical therapy; Transcutaneous Electrical Nerve Stimulation, hotpack
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Low-dose Atropine for Myopia Control in Children
Status: RECRUITING
Conditions: Myopia, Progressive
Interventions: DRUG: Atropine eye drops, 0.01%|DRUG: Atropine eye drops, 0.02%|DRUG: Placebo (NaCl 0.9%) eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bleaching Effect of Strawberry Extract Versus Hydrogen Peroxide in Patients With Extrinsic Staining
Status: NOT_YET_RECRUITING
Conditions: Bleaching Effect and Postoperative Sensitivity of Strawberry Extract
Interventions: OTHER: strawberry extract.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Progressive Resistance Training of the Extensor Muscle of the Thigh in COPD-patients Hospitalized With an Exacerbation
Status: WITHDRAWN
Conditions: COPD - Chronic Obstructive Pulmonary Disease|Muscle Atrophy
Interventions: OTHER: Intervention-training-group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: NE3107 Activity and Safety in Patients With Parkinson's Disease Using Levodopa
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: NE3107|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Biofilm Characteristics Between an in Situ Biofilm Model of Supragingival Plaque and Natural Teeth
Status: UNKNOWN
Conditions: Biofilm|Dental Plaque
Interventions: OTHER: Toothbrushing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of the Sedation Effect of Esketamine and Sevoflurane for Pediatric Ophthalmological Procedure
Status: COMPLETED
Conditions: Adverse Event
Interventions: DRUG: Esketamine|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autonomic Modulation Training for Police Exposed to Post-Traumatic Stress Injuries
Status: RECRUITING
Conditions: Stress, Physiological|Stress, Psychological
Interventions: BEHAVIORAL: Autonomic Modulation Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ShorT and OPtimal Duration of Dual AntiPlatelet Therapy-2 Study
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: 1-month DAPT|DRUG: 12-month DAPT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Norovirus Challenge Model
Status: COMPLETED
Conditions: Gastroenteritis Norovirus
Interventions: BIOLOGICAL: Norovirus GII.4 Challenge Pool
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sentinel Lymph Node Biopsy and Primary Tumor Gene Expression Profiling in Finding Axillary Lymph Node Metastases in Women Who Have Received Neoadjuvant Therapy for Stage II, Stage III, or Stage IV Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: GENETIC: microarray analysis|OTHER: immunohistochemistry staining method|PROCEDURE: conventional surgery|PROCEDURE: lymphangiography|PROCEDURE: radionuclide imaging|PROCEDURE: sentinel lymph node biopsy|RADIATION: technetium Tc 99m sulfur colloid
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: HLADQA1*05 Genotype and the Efficacy of Treatment With Infliximab in Chinese Population Crohn's Disease
Status: NOT_YET_RECRUITING
Conditions: Crohn Disease|Infliximab
Interventions: DRUG: Azathioprine|DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Modified Triple Doublet Therapy in Women With Newly Diagnosed Mullerian Carcinoma
Status: COMPLETED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Cancer
Interventions: DRUG: Chemotherapy, multiple agents
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation to Assess Safety and Tolerability of DM199 in Subjects With Acute Ischemic Stroke
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Recombinant human tissue kallikrein|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaped Marijuana to Attenuate Naloxone-Precipitated Withdrawal
Status: SUSPENDED
Conditions: Opioid Overdose
Interventions: DRUG: Naloxone|DRUG: Marijuana
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Apatinib After Systemic Therapy in Patients With Hepatocellular Carcinoma(AHELP)
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Apatinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Progesterone Primed Ovarian Stimulation Protocol Versus Antagonist Protocol for PCO Patient
Status: NOT_YET_RECRUITING
Conditions: Polycystic Ovary Syndrome|Infertility|IVF
Interventions: DRUG: Progesterone antagonist|DRUG: conventional antagonist protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Neurally Adjusted Ventilator Assist (NAVA) Mode on Patient Ventilator Asynchrony Using Non-invasive Ventilation (NAVA-NIV)
Status: COMPLETED
Conditions: Weaning Period
Interventions: OTHER: Device: Neurally Adjusted Ventilatory Assistance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intensity-Modulated Radiation Therapy to the Pelvis With or Without Chemotherapy in Treating Patients With Endometrial Cancer or Cervical Cancer That Has Been Removed By Surgery
Status: COMPLETED
Conditions: Cervical Cancer|Endometrial Cancer
Interventions: DRUG: cisplatin|RADIATION: intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Comparing Oxygen Delivery Via Helmet Interface Versus High Flow Nasal Cannula
Status: UNKNOWN
Conditions: Hypoxemic Respiratory Failure
Interventions: DEVICE: Helmet|DEVICE: High Flow Nasal Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Desflurane Anesthesia Versus TIVA-TCI in Patients Undergoing Ophthalmic Ambulatory Surgery
Status: COMPLETED
Conditions: Ophthalmic|Surgery|Anesthesia
Interventions: DRUG: desflurane|PROCEDURE: total intravenous anesthesia|PROCEDURE: inhalation anesthesia|DRUG: Propofol|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Dexlansoprazole in Asian Participants With Gastroesophageal Reflux Disease
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: Dexlansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simulating Outcomes From Breast Conserving Surgery Using 3D Surface Imaging
Status: UNKNOWN
Conditions: Breast Cancer Female
Interventions: OTHER: 3-dimensional photograph with simulation|OTHER: Viewing of a 2-dimensional photographic library
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: STI571 Plus Combination Chemotherapy in Treating Patients With Chronic Myelogenous Leukemia or Acute Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: daunorubicin hydrochloride|DRUG: imatinib mesylate|DRUG: prednisone|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Preventing Anxiety and Depression in Older Hispanics
Status: RECRUITING
Conditions: Depression|Anxiety
Interventions: BEHAVIORAL: HOLA Component 1|BEHAVIORAL: HOLA Component 2|BEHAVIORAL: HOLA Component 3|BEHAVIORAL: HOLA Component 4|BEHAVIORAL: Healthy lifestyles education program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy in Treating Patients With Unresectable Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: FOLFIRI regimen|DRUG: FOLFOX regimen|DRUG: fluorouracil|DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peripheral Skin Temperature Changes Following Spinal Anaesthesia for Category 4 LSCS
Status: RECRUITING
Conditions: Anesthesia
Interventions: BEHAVIORAL: Seeking informed consent for participation in the study.|DEVICE: Temperature measurement by Braun Welch Allyn tympanic membrane thermometer device to the dorsum of the right and left feet above space between the 2nd and 3rd metatarsal bones.|DEVICE: Covidien Mon-a-Therm skin temperature probes will be applied to the dorsum of the right and left feet above space between the 2nd and 3rd metatarsal bones.|DEVICE: Temperature measurement by Braun Welch Allyn tympanic membrane thermometer device to the ear.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Botulinum Toxin A vs Anticholinergic Treatment of Neurogenic Overactive Bladder in Patients With Multiple Sclerosis
Status: UNKNOWN
Conditions: Urinary Bladder, Neurogenic|Multiple Sclerosis
Interventions: DRUG: VESIcare 10Mg Tablet|DRUG: Botox 100 UNT Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pioglitazone on Microcirculation in Type 2 Diabetes Patients Treated With Insulin
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PANVAC™-VF Vaccine for the Treatment of Metastatic Pancreatic Cancer After Failing a Gemcitabine-Containing Regimen
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: PANVAC™-VF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Lenvatinib in Participants With Refractory Differentiated Thyroid Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Thyroid Neoplasms
Interventions: DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Azithromycin for Lymphocytic Bronchiolitis/Bronchitis After Lung Transplantation
Status: COMPLETED
Conditions: Lymphocytic Bronchi(Oli)Tis Post-lung Transplantation
Interventions: DRUG: Azithromycin Dihydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Connective Tissue Manipulation on Menopausal Symptoms
Status: COMPLETED
Conditions: Menopause Syndrome
Interventions: OTHER: Connective tissue manipulation|OTHER: Superficial massage with the head of the therapeutic ultrasound device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Clinical Study of RPH-104 in Adult Onset Still's Disease (AOSD)
Status: WITHDRAWN
Conditions: Adult-Onset Still's Disease|AOSD
Interventions: BIOLOGICAL: RPH-104|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exploring Regulation and Function of Dopamine D3 Receptors in Alcohol Use Disorders: A [11C]-(+)-PHNO Study
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: OTHER: [11C]-(+)-PHNO PET scan|OTHER: Alcohol Self-Administration|OTHER: Craving Task|OTHER: MRI scan|OTHER: Neuropsychological Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: Low Dose Benfotiamine|DRUG: High Dose Benfotiamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the ElastiMed's SACS 2.0 - Smart Active Compression Stocking for the Treatment of Venous Edema
Status: UNKNOWN
Conditions: Edema Leg|Compression; Vein
Interventions: DEVICE: ElastiMed's SACS 2.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuropsycholgy and Neuroimaging in Transient Global Amnesia
Status: TERMINATED
Conditions: Transient Global Amnesia (TGA)
Interventions: BEHAVIORAL: Neuropsychological tests|DEVICE: Cerebral imaging (MRI, PET-FDG)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of TIVA Propofol vs Sevoflurane Anaesthetic on Serum Biomarkers and on PBMCs in Breast Cancer Surgery
Status: WITHDRAWN
Conditions: Female Breast Cancer
Interventions: DRUG: 2,6-Diisopropylphenol|DRUG: Fluoromethyl hexafluoroisopropyl ether|DRUG: Fentanyl Citrate|DRUG: Atracurium Besylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Development and Evaluation of a Patient-centered Transition Program for Stroke Patients, Combining Case Management and Access to an Internet Information Platform
Status: UNKNOWN
Conditions: Stroke
Interventions: OTHER: A co-design phase aims to ensure the feasibility and relevance of the proposed intervention and evaluation.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Vaccine Therapy in Treating Patients With Persistent or Recurrent Cervical Cancer
Status: COMPLETED
Conditions: Cervical Adenocarcinoma|Cervical Adenosquamous Carcinoma|Cervical Squamous Cell Carcinoma, Not Otherwise Specified|Recurrent Cervical Carcinoma
Interventions: BIOLOGICAL: Attenuated Live Listeria Encoding HPV 16 E7 Vaccine ADXS11-001|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CALM: Managing Distress in Malignant Brain Cancer
Status: RECRUITING
Conditions: Brain Tumor|Brain Metastases|Brain Cancer|Metastatic Lung Cancer|Metastatic Breast Cancer|Metastatic Melanoma|Metastatic Colon Cancer|Metastatic Kidney Cancer
Interventions: BEHAVIORAL: CALM|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Motivational Interviewing for Nurses' Smoking Cessation
Status: COMPLETED
Conditions: Health Behavior|Smoking Cessation|Health Personnel Attitude
Interventions: BEHAVIORAL: Motivational interviewing for smoking cessation in nurses|BEHAVIORAL: Brief advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Plus Bone Marrow Transplantation in Treating Patients With Metastatic Melanoma
Status: TERMINATED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: filgrastim|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: methotrexate|PROCEDURE: allogeneic bone marrow transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of Levulan With New Blue Light for AK on the Face or Scalp
Status: WITHDRAWN
Conditions: Actinic Keratosis
Interventions: DRUG: ALA|DRUG: Vehicle|DEVICE: IBL 20 mW|DEVICE: IBL 10 mW
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Warming Comparison of Devices
Status: COMPLETED
Conditions: Hypothermia
Interventions: DEVICE: Dynatherm Medical vitalHEAT Temperature Management System vH2|DEVICE: Bair Hugger™ (Arizant Healthcare, Eden Prairie, MN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose Escalation Study to Evaluate Oral Rotavirus Vaccine 116E Live Attenuated in Healthy Infants 8 to 20 Weeks Old
Status: COMPLETED
Conditions: Diarrhea
Interventions: BIOLOGICAL: Oral Rotavirus Vaccine 116E Live Attenuated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Open-label Extension (OLE) Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD)
Status: TERMINATED
Conditions: ALS|FTD
Interventions: DRUG: WVE-004
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pretargeted Radioimmunotherapy of a Anti-CEA Bispecific Antibody and Lu177-labeled Peptide in Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: DRUG: TF2|DRUG: IMP-288 labeled with In111 and Lu177
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise Intolerance in Elderly Patients With Diastolic Heart Failure
Status: COMPLETED
Conditions: Heart Failure, Diastolic|Obesity
Interventions: BEHAVIORAL: Exercise|DIETARY_SUPPLEMENT: Dietary Intervention|BEHAVIORAL: Diet and exercise|OTHER: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: rTMS and Body Weight-support Treadmill Training After Incomplete Spinal Cord Injury
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: DEVICE: High frequency repetitive transcranial magnetic stimulation|DEVICE: Sham High frequency repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Lenalidomide to Evaluate Safety and Effectiveness in Patients With Diffuse Large B-Cell Lymphoma (DLBCL)
Status: COMPLETED
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: Lenalidomide|DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Rituximab|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Awareness in Old Aged Patients During Laryngoscopy and Intubation Using Isolated Forearm Technique
Status: COMPLETED
Conditions: Awareness, Anesthesia|Recall Phenomenon|Inhalation; Gas
Interventions: DRUG: Sevoflurane|DRUG: TIVA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Trial to Investigate Treatment With Photodynamic Therapy to Reduce Levels of Bacteria in Leg Ulcers
Status: COMPLETED
Conditions: Chronic Leg Ulcers|Wound Healing
Interventions: DRUG: Topical PPA904 gel and light|DRUG: Topical placebo gel plus light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability, and Pharmacokinetics of a Single Ascending Dose of AZD0292 In Healthy Participants
Status: RECRUITING
Conditions: Healthy Participants Study
Interventions: DRUG: AZD0292|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Complete Decongestive Therapy on Head and Neck Lymphedema
Status: COMPLETED
Conditions: Lymphedema of Face|Secondary Lymphedema
Interventions: PROCEDURE: Complete Decongestive Therapy|OTHER: Observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Safety and Effect of Sparsentan in Combination With SGLT2 Inhibition in Participants With IgAN
Status: ACTIVE_NOT_RECRUITING
Conditions: Immunoglobulin A Nephropathy
Interventions: DRUG: Sparsentan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluconazole Pharmacokinetics, Including Bioavailability, in Obese Subjects After an Intravenous and Oral Administration
Status: COMPLETED
Conditions: Fluconazole|Candidiasis|Invasive Fungal Infections|Obesity
Interventions: DRUG: Fluconazole 200mg tab|DRUG: Fluconazole 2 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACTISAVE: ACuTe Ischemic Stroke Study Evaluating Glenzocimab Used as Add-on Therapy Versus placEbo
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Intravenous glenzocimab (ACT017) 1000 mg|DRUG: Intravenous Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Virtual Reality Stabilization Training in Patients With Low Back Pain
Status: NOT_YET_RECRUITING
Conditions: Low Back Pain
Interventions: DEVICE: Virtual Reality (VR)|OTHER: Regular Exercises|OTHER: patient instructions and education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electroencephalogram (EEG) in General Anaesthesia - More Than Only a Bispectral Index (BIS)
Status: COMPLETED
Conditions: Anesthesia
Interventions: OTHER: Training for EEG monitoring|OTHER: Standard monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: "The Effect of the Use of an Autotransfusion Device on Hemodynamic Parameters During Resuscitation".
Status: RECRUITING
Conditions: Out of Hospital Cardiac Arrest|Cardiac Arrest
Interventions: DEVICE: HemaShock device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Pediatric Participants With Nonsegmental Vitiligo
Status: NOT_YET_RECRUITING
Conditions: NonSegmental Vitiligo
Interventions: DRUG: Ruxolitinib Cream|DRUG: Vehicle Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Good Start Matters - Parenting Program
Status: RECRUITING
Conditions: Parenting Practices|Co-parenting Practices|Child Eating and Dietary Behaviors|Child Physical Activity/Active Play/Outdoor Play|Child Screen Time
Interventions: BEHAVIORAL: Good Start Matters - Parenting intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Beyond Confounders: Addressing Source of Measurement Variability and Error in Shear Wave Elastography
Status: COMPLETED
Conditions: Liver Fibrosis|Liver Diseases
Interventions: DEVICE: Sonographic SWE measurements with 4 different ultrasound systems
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Marginal Bone Loss After Immediate Implant Placement in Maxillary Esthetic Zone With Nanobone Versus Xenograft
Status: UNKNOWN
Conditions: Implant Placement in Maxillary Esthetic Zone
Interventions: DEVICE: Implant with NanoBone graft|DEVICE: Implant with Xenograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Total Intravenous Anaesthesia (TIVA) Versus Spinal Anaesthesia in Patients Undergoing Transurethral Prostate Resection
Status: COMPLETED
Conditions: Prostate|Hyperplasia
Interventions: PROCEDURE: total intravenous anaesthesia|PROCEDURE: spinal anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HPV-cytology Testing Versus Cytology Testing for the Detection of High Grade CIN
Status: UNKNOWN
Conditions: Cervical Cancer|Cervical Intraepithelial Neoplasia
Interventions: PROCEDURE: HPV-cytology co-testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability Study of ZEP-3 Cream (0.1% and 1.0%), Administered Topically In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 0.1% ZEP-3 cream|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Nourishing Beginnings: Addressing Food Insecurity During Pregnancy
Status: RECRUITING
Conditions: Pregnancy Related|Food Insecurity|Premature Birth|Pregnancy Complications
Interventions: BEHAVIORAL: Food Delivery|OTHER: Financial Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Antiseptic Effects on the Dental Implant Internal Surface Microbiome
Status: RECRUITING
Conditions: Peri-Implantitis|Peri-implant Mucositis|Implant Infection|Dental Implant Failed
Interventions: DRUG: Chlorhexidine|DRUG: Hydrogen Peroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dorsal Scapular Nerve Injection Combined With Muscle Needle Release
Status: NOT_YET_RECRUITING
Conditions: Dorsal Scapular Nerve Entrapment
Interventions: OTHER: Ultrasound-guided injection combined with needle release
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Triclosan Formulation to Control the Initial Subgingival Biofilm Formation
Status: COMPLETED
Conditions: Dental Plaque
Interventions: OTHER: Test - Using of a suspension containing Triclosan|OTHER: Control - Using of a suspension without Triclosan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Videos and Questionnaires in Assessing Patient Perception of Physician's Compassion, Communication Skills, and Professionalism During Clinic Visits
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Neoplasm|Locally Advanced Malignant Neoplasm|Malignant Neoplasm|Metastatic Malignant Neoplasm|Recurrent Malignant Neoplasm
Interventions: OTHER: Questionnaire Administration|OTHER: Video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Conjunctival Antimicrobial Activity and Patient Comfort Between Topical Hypochlorous Acid (Avenova) and Betadine
Status: RECRUITING
Conditions: Eye Infections, Bacterial
Interventions: DRUG: Betadine|DRUG: Avenova
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Amrubicin With or Without Cisplatin Versus Etoposide-cisplatin for Extensive Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Amrubicin|DRUG: Cisplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of Different Bowel Preparation Before Colonoscopy in Children Over 2 Years Old
Status: COMPLETED
Conditions: Child Obesity|Bowel Preparation
Interventions: OTHER: PEG-ELS-S|OTHER: PEG-ELS-L
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Multi-Center Study of Rehabilitation to Stable Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: UNKNOWN
Conditions: COPD|Inflammation
Interventions: BEHAVIORAL: cycling, walking|BEHAVIORAL: cycling, non-walking|BEHAVIORAL: walking, walking|BEHAVIORAL: walking, non-walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate a Single Dose of STI-2020 (COVI-AMG™) in Adults With Mild COVID-19 Symptoms
Status: WITHDRAWN
Conditions: Covid19
Interventions: BIOLOGICAL: COVI-AMG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Video-Assisted Surgery or Talc Pleurodesis in Treating Patients With Malignant Mesothelioma
Status: COMPLETED
Conditions: Malignant Mesothelioma|Metastatic Cancer
Interventions: OTHER: talc|PROCEDURE: therapeutic thoracoscopy|PROCEDURE: therapeutic videothoracoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of Once a Week Risedronate on the Microstructure of Tibia and Radius Using a New Scanning Method
Status: COMPLETED
Conditions: Osteopenia
Interventions: DRUG: Placebo comparator|DRUG: risedronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of rAAV2tYF-GRK1-RPGR in Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations
Status: ACTIVE_NOT_RECRUITING
Conditions: X-Linked Retinitis Pigmentosa
Interventions: BIOLOGICAL: rAAV2tYF-GRK1-RPGR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IN Insulin in Type 1 Diabetes (T1D) Hypoglycemia Unawareness: Safety Only Phase
Status: TERMINATED
Conditions: Type1diabetes
Interventions: DRUG: Regular insulin (Humulin-R), intranasal route|DEVICE: SipNose intranasal device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Noninvasive 3D Mapping in Persistent Atrial Fibrillation, to Describe Modifications of the Arrhythmogenic Substrate After Pulmonary Vein Isolation and Identify Potential Predicting Factors of Ablation Success
Status: UNKNOWN
Conditions: Atrial Fibrillation, Persistent
Interventions: DEVICE: Noninvasive mapping (Cardioinsight® system)|DEVICE: long-term cardiac monitoring (LINQ system)|PROCEDURE: Atrial Fibrillation ablation procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Single and Multiple Doses of an Oral Formulation of L-Homoarginine in Healthy Human Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: L-Homoarginine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Development of a Remote Therapy Protocol for Upper Limb Function Enhancement in Children With Cerebral Palsy
Status: NOT_YET_RECRUITING
Conditions: Cerebral Palsy
Interventions: OTHER: Home-based hand-arm bimanual intensive training (Tele-HABIT)|OTHER: Hand-arm bimanual intensive training (In-clinic-HABIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of One-site and Two-site Peribulbar Anaesthesia for Cataract Surgery at Kaduna, Nigeria
Status: COMPLETED
Conditions: Anaesthesia|Cataract
Interventions: PROCEDURE: One-site peribulbar injection|PROCEDURE: Two- site peribulbar injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: pAF for the Treatment of Osteoarthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteo Arthritis Knee
Interventions: BIOLOGICAL: Amniotic Fluid Injection|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Roll Over Study to Provide Idelalisib to Participants Previously Treated With the Investigational PI3Kδ Inhibitor, GS-9820
Status: TERMINATED
Conditions: Lymphoid Malignancies
Interventions: DRUG: Idelalisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sex, Psychopharmacology, and Diabetes
Status: RECRUITING
Conditions: Schizophrenia|Schizophrenia Spectrum and Other Psychotic Disorders|Diabetes Mellitus|PreDiabetes|Sexual Dysfunction|Drug-Related Side Effects and Adverse Reactions|Education
Interventions: BEHAVIORAL: Educational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Subconjunctival Versus Direct Mitomycin C in Trabeculectomy
Status: COMPLETED
Conditions: Open Angle Glaucoma
Interventions: DRUG: Mitomycin-C injection|DRUG: Mitomycin-C sponge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Training in Severe Post-Stroke Walking Impairment
Status: RECRUITING
Conditions: Stroke|Chronic Stroke|Walking, Difficulty|Gait, Hemiplegic
Interventions: BEHAVIORAL: Backward Locomotion Treadmill Training (BLTT)|BEHAVIORAL: Forward Locomotion Treadmill Training (FLTT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Caregiver Support for Heart Failure Patients: the CarePartner Study
Status: COMPLETED
Conditions: Heart Failure, Congestive
Interventions: BEHAVIORAL: HITCM+CP|BEHAVIORAL: HITCM only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Early Verticalization of the Patient With Acute Respiratory Distress Syndrome: Assessment of Feasibility and Safety.
Status: RECRUITING
Conditions: Acute Respiratory Distress Syndrome|Prone Position
Interventions: PROCEDURE: Verticalization and Prone position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Assessment of Prevident Sodium Fluoride 1.1% Toothpaste Using an Intra-oral Remineralization-demineralization Model
Status: WITHDRAWN
Conditions: Dental Caries
Interventions: DRUG: Fluoride Free toothpaste|DRUG: 1.1% Fluoride toothpaste|DRUG: 0.243% Fluoride toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RAD001 Plus Octreotide Depot in Metastatic or Unresectable Low Grade Neuroendocrine Carcinoma
Status: COMPLETED
Conditions: Neuroendocrine Carcinoma|Islet Cell Carcinoma
Interventions: DRUG: RAD001|DRUG: Octreotide Depot
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bed Rest, Alternate Daily Fasting and Incretin Effect
Status: COMPLETED
Conditions: Metabolic Syndrome|Type 2 Diabetes|Critical Illness
Interventions: OTHER: Bed rest|OTHER: OGTT|OTHER: IVGTT|OTHER: Cognitive testing|OTHER: Muscle and fat biopsies|OTHER: Dual-energy X-ray Absorptiometry (DXA) scan|OTHER: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Skin Rash Study Before Chemotherapy in Colorectal & Head and Neck Cancer Patients
Status: COMPLETED
Conditions: Colorectal Cancer|Head and Neck Cancer
Interventions: DRUG: Doxycycline|DRUG: Hydrocortisone 1% cream|OTHER: Sunscreen|OTHER: Moisturizer|DRUG: Clindamycin|DRUG: Medrol-dose pack (Steroid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Terlipressin in Septic Shock in Cirrhosis
Status: COMPLETED
Conditions: Liver Cirrhosis|Septic Shock
Interventions: DRUG: Terlipressin|DRUG: alpha adrenergic drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Jobelyn™ Consumption on Hemoglobin Levels in a Borderline Anemic Population
Status: COMPLETED
Conditions: Anemia
Interventions: DIETARY_SUPPLEMENT: Jobelyn™|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Impact of Non-surgical Periodontal Therapy on Patients' Halitosis, Taste Perception, and Smell Sensation
Status: ENROLLING_BY_INVITATION
Conditions: Gingivitis|Periodontitis
Interventions: DIAGNOSTIC_TEST: Periodontal examination|OTHER: baseline questionnaire about sociodemographic characteristics, smoking habits, oral hygiene habits, halitosis, smell and taste perception|OTHER: phase I periodontal treatment|OTHER: 1. month periodontal evaluation and repeat questionnaire|OTHER: 3. month periodontal evaluation and repeat questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treating Early Stage Diabetic Retinopathy
Status: ENROLLING_BY_INVITATION
Conditions: Diabetic Retinopathy
Interventions: DRUG: Sinemet CR|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Novel Experimental COVID-19 Therapies Affecting Host Response
Status: COMPLETED
Conditions: COVID-19|SARS-CoV-2 Infection|Coronavirus Infection
Interventions: DRUG: TXA127|DRUG: TRV027|DRUG: Placebo|DRUG: Fostamatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clowns as Treatment for Preoperative Anxiety in Children: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Pre Operative Anxiety
Interventions: BEHAVIORAL: clowns present|DRUG: midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: APR-246 in Combination With Venetoclax and Azacitidine in TP53-Mutant Myeloid Malignancies
Status: COMPLETED
Conditions: Myeloid Malignancy
Interventions: DRUG: APR-246|DRUG: Venetoclax|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety and Tolerability of Carbognilumab Combined With Chemotherapy as the First-line Treatment for Patients With KEAP1 Mutated Advanced or Postoperative Recurrent Non-small Cell Lung Cancer (NSCLC)
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: cadonilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ovarian PRP (Platelet Rich Plasma) Injection for Follicular Activation
Status: RECRUITING
Conditions: Premature Ovarian Insufficiency|Infertility, Female|Sterility, Female|PRP
Interventions: BIOLOGICAL: autologous PRP (platelet rich plasma)|OTHER: Saline solution (NaCL) Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Compare the Effect of a Subcutaneous Canakinumab Administration to Placebo in Patients With Impaired Glucose Tolerance or Patients With Type 2 Diabetes With Differing Baseline Diabetes Therapies
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Impaired Glucose Tolerance
Interventions: DRUG: Canakinumab 150 mg|DRUG: Placebo to Canakinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Iron for Treatment of Anaemia Before Cardiac Surgery
Status: RECRUITING
Conditions: Anaemia
Interventions: DRUG: Ferric carboxymaltose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate Efficacy and Safety of Lenabasum in Dermatomyositis
Status: COMPLETED
Conditions: Dermatomyositis
Interventions: DRUG: Lenabasum 20 mg|DRUG: Lenabasum 5 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dysphagia, QoL and Attitudes Towards PEG in ALS Patients
Status: RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DIAGNOSTIC_TEST: Iowa Oral Performance Instrument (IOPI)|DIAGNOSTIC_TEST: Mann Assessment of Swallowing Ability (MASA)|DIAGNOSTIC_TEST: Fiberoptic Endoscopic Evaluation of Swallowing|DIAGNOSTIC_TEST: Respiratory function measurements
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Delivery of Intravesical Botulinum Toxin A Using Low Energy Shock Waves in Treatment of Overactive Bladder: A Feasibility Study
Status: UNKNOWN
Conditions: Overactive Bladder|Botulinum Toxin|Intravesical|ESWL
Interventions: OTHER: ESWL BOTOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Stem Cell Therapy in Ambulatory and Non-ambulatory Children With Duchenne Muscular Dystrophy - Phase 1-2
Status: UNKNOWN
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: Biological: Umbilical Cord Based Allogenic Mesenchymal Stem Cell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT