pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Glycopyrrolate and Atropine on Catheter-Related Bladder Discomfort
Status: UNKNOWN
Conditions: Catheter Site Discomfort|Complications|Anesthesia|Urinary Bladder Neoplasms
Interventions: DRUG: Glycopyrrolate|DRUG: Atropine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: FlowTriever All-Comer Registry for Patient Safety and Hemodynamics
Status: ACTIVE_NOT_RECRUITING
Conditions: PE - Pulmonary Embolism|PE - Pulmonary Thromboembolism
Interventions: DEVICE: FlowTriever System|DRUG: Anticoagulation Agents
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: 5-Azacytidine|DRUG: Valproic Acid|DRUG: ATRA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
Status: RECRUITING
Conditions: Solid Tumors|Hematologic Malignancies
Interventions: DRUG: Pembrolizumab|DRUG: Standard of Care (SOC)|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose-finding and Confirmatory Trial of OPC-6535 in Patients With Active Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: Placebo|DRUG: OPC-6535|DRUG: OPC-6535
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DIAN-TU Amyloid Removal Trial (ART) in Dominantly Inherited Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer's Disease|Dementia|Alzheimer's Disease, Familial
Interventions: DRUG: lecanemab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety, Tolerability and Pharmacokinetic Study of Yimitasvir in Healthy Adults Subjects
Status: COMPLETED
Conditions: Chronic Hepatitis c
Interventions: DRUG: yimitasvir|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy People to Compare 3 Different Formulations of Apremilast Tablets Taken With or Without Food
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: EU-sourced Otezla®|DRUG: US-sourced Otezla®|DRUG: Japan-sourced Otezla®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Platelet-rich Plasm (PRF) on Two-implant Mandibular Overdenture: a Split Mouth
Status: UNKNOWN
Conditions: Edentulous Jaw|Dental Implant Failed
Interventions: PROCEDURE: Implant installation with PRF membrane|PROCEDURE: Implant installation without PRF membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allograft Reconstruction of Massive Rotator Cuff Tears vs Partial Repair Alone
Status: COMPLETED
Conditions: Rotator Cuff Syndrome|Rotator Cuff Injury|Disorder of Rotator Cuff|Full Thickness Rotator Cuff Tear|Skin Graft (Allograft) (Autograft) Failure
Interventions: PROCEDURE: Partial Rotator Cuff Repair|PROCEDURE: Partial Rotator Cuff Repair with Allograft Augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Shared Decision Making About Medication Use for People With Multiple Health Problems
Status: COMPLETED
Conditions: Polypharmacy|Dementia|Multiple Chronic Conditions|Deprescribing|Mild Cognitive Impairment
Interventions: OTHER: Educational Materials
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Nipocalimab in Children Aged 2 to Less Than 18 Years With Generalized Myasthenia Gravis
Status: RECRUITING
Conditions: Myasthenia Gravis
Interventions: DRUG: Nipocalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of a Subcutaneous Tanezumab Titration Dosing Regimen in Subjects With Moderate to Severe Osteoarthritis of the Hip or Knee
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Osteoarthritis, Hip
Interventions: OTHER: Placebo|BIOLOGICAL: Tanezumab 2.5 mg|BIOLOGICAL: Tanezumab 2.5mg/5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Immunogenicity and Safety of a HIPRA's Candidate Booster Vaccination in Adults Fully Vaccinated With Adenovirus Vaccine Against COVID-19.
Status: COMPLETED
Conditions: COVID-19|SARS-CoV-2 Acute Respiratory Disease
Interventions: BIOLOGICAL: COVID-19 Vaccine HIPRA 40 ug/dose|BIOLOGICAL: Comirnaty (Pfizer-BioNtech) 30 ug/dose concentrate for dispersion for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Age Influence on the Modifications of the Oral, Pharyngeal and Laryngeal Axis Alignment in Children Induced by Head Extension: an MRI Study
Status: COMPLETED
Conditions: Head Extension on the Anatomic Axes of the Superior Airway
Interventions: PROCEDURE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Antiviral Activity, Clinical Outcomes, Safety, Tolerability, and Pharmacokinetics of Orally Administered Lumicitabine Regimens in Adult Participants Hospitalized With Respiratory Syncytial Virus
Status: TERMINATED
Conditions: Respiratory Syncytial Viruses
Interventions: DRUG: lumicitabine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Pectoral Nerve Block on Post-op Pain in Patients Undergoing Mastectomy and Immediate Reconstruction
Status: UNKNOWN
Conditions: Breast Neoplasm
Interventions: DEVICE: Ultrasound|DRUG: 0.25% bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atorvastatin Calcium and Celecoxib in Treating Patients With Rising PSA Levels After Local Therapy for Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: atorvastatin calcium|DRUG: celecoxib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Portal-based Advance Care Planning Intervention Among Community-Dwelling Persons Living With Cognitive Impairment
Status: RECRUITING
Conditions: Advanced Care Planning
Interventions: BEHAVIORAL: Advance Care Planning Tool - ACPVoice|BEHAVIORAL: Standard of Care for Advance Care Planning
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Marijuana's Impact on Alcohol Motivation and Consumption
Status: COMPLETED
Conditions: Alcohol Drinking|Marijuana
Interventions: DRUG: THC 7.2%|DRUG: THC 3.0%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Low-level Laser Therapy During Maxillary Molar Distalization Using a Skeletally Anchored Appliance
Status: UNKNOWN
Conditions: Class II Division 1 Malocclusion
Interventions: OTHER: Distalization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation Of Clinical Pharmacy Services in Patients Receiving Antithrombotic Treatment
Status: COMPLETED
Conditions: Cardiovascular Diseases|Drug Use
Interventions: BEHAVIORAL: Intervention Group: Group to which the clinical pharmacist makes recommendations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation the Safety and Efficacy of Lyophilized Fecal Microbiota Transplantation Administered Orally for Prevention of Relapse or Intestinal Inflammation in Adults With Ulcerative Colitis
Status: RECRUITING
Conditions: Adults With Ulcerative Colitis
Interventions: DRUG: PRIM-DJ2727|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mycophenolate Mofetil in Patients With Progressive Idiopathic Membranous Nephropathy
Status: UNKNOWN
Conditions: Glomerulonephritis, Membranous
Interventions: DRUG: Mycophenolate mofetil, low dose steroid|DRUG: Cyclosporin, low dose steroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Performance of a New 2-piece Ostomy Appliance vs. Flexima® 3S in Patients With Enterostomy
Status: UNKNOWN
Conditions: Enterostomy
Interventions: DEVICE: Flexima 3S|DEVICE: New 2-piece ostomy appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study Assessing the Safety, Tolerability, and Pharmacokinetics of SEP-363856 in Male and Female Subjects With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: SEP-363856|DRUG: Placebo|DRUG: SEP-363856 Open Label
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Coronary Plaque Composition Using Optical Coherence Tomography
Status: COMPLETED
Conditions: Coronary Atherosclerosis|Endothelial Dysfunction|Coronary Small Vessel Disease
Interventions: DEVICE: Optical Coherence Tomography (C7 XR Dragonfly )
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Eyelid Patching After Ptosis Surgery
Status: COMPLETED
Conditions: Ptosis, Eyelid
Interventions: OTHER: Compression dressing (build by Kompressen, gauze swabs, Nobamed Paul Danz AG, Wetter, Germany and NOBALUMENAL® - steril, eye pad, Nobamed Paul Danz AG, Wetter, Germany
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Dose Trial Investigating Safety and Local Tolerability of Ascending Doses of Long Acting Activated Recombinant Human Factor VII in Healthy Male Volunteers
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A|Haemophilia B|Healthy
Interventions: DRUG: activated recombinant human factor VII, long acting|DRUG: placebo|DRUG: activated recombinant human factor VII, long acting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Three Different Embryo Transfer Media in ICSI Cycles
Status: UNKNOWN
Conditions: Improvement of Embryo Transfer Technique|Improvement of Implantation
Interventions: OTHER: embryos will be transferred using a medium of 0.5 mg/mL of Hyaluronan-enriched medium (EmbryoGlue®, Vitrolife, Sweden)|OTHER: embryos will be transferred using a medium of 30% Protein-supplemented Culture Medium (Global total®, Life Global group, Canada)|OTHER: a novel technique in which embryos will be transferred using a medium of autologous Follicular Fluid|DEVICE: Labotect embryo transfer catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effectiveness of Atomoxetine in Treating ADHD Symptoms in Children and Adolescents With Autism
Status: COMPLETED
Conditions: Autism
Interventions: DRUG: Atomoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Sorafenib Added to Standard Primary Therapy in Patients With Newly Diagnosed Acute Myeloid Leukemia Less Than 60 Years of Age
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: sorafenib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Video Telehealth Gait Retraining for Running-Related Knee Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Telemedicine|Running|Knee|Pain
Interventions: PROCEDURE: Telehealth Gait Retraining|PROCEDURE: Standard Physical Therapy Treatment|PROCEDURE: Return to Running Protocol|PROCEDURE: At Home Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Addition of Prednisolone and Heparin in Patients Undergoing IVF With Failed IVF Cycles
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Prednisolone and Heparin during COH for IVF|DRUG: COH for IVF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Orofacial Myofunctional Therapy With Autofeedback on Obstructive Sleep Apnea
Status: RECRUITING
Conditions: Sleep Apnea, Obstructive
Interventions: BEHAVIORAL: Orofacial myofunctional therapy with autofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Catgut Implantation at Acupoints for the Treatment of Simple Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: DEVICE: Real catgut implantation at acupoints|DEVICE: sham catgut implantation at acupoints
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of F-Fluorodeoxyglucose (FluGlucoScan) in Patients With Known or Suspected Cancers of Low Incidence
Status: COMPLETED
Conditions: Sarcoma|Multiple Myeloma|Testicular Neoplasms|Ovarian Neoplasms|Kidney Neoplasms
Interventions: PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Persuasive Health Communication Intervention for HIV/HCV
Status: RECRUITING
Conditions: Human Immunodeficiency Virus (HIV)|Hepatitis C (HCV)
Interventions: OTHER: Video Format with Captions|OTHER: Video Format without Captions|OTHER: Health Educator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of TPX-0022 in Patients With Advanced NSCLC, Gastric Cancer or Solid Tumors Harboring Genetic Alterations in MET
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumor|Metastatic Solid Tumors|MET Gene Alterations
Interventions: DRUG: elzovantinib (TPX-0022)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Radiation for High Risk Bladder Cancer
Status: TERMINATED
Conditions: Bladder Cancer|Squamous Cell Carcinoma of the Bladder|Stage III Bladder Cancer|Stage IV Bladder Cancer|Transitional Cell Carcinoma of the Bladder
Interventions: RADIATION: 3D conformal radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Lunch Study: the Combined Effects of Food Texture and Portion Size on Intake
Status: COMPLETED
Conditions: Satiation
Interventions: OTHER: Thin/100% Portion|OTHER: Thin/150% Portion|OTHER: Thick/100% Portion|OTHER: Thick/150% Portion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prevention Allergic Disease of Infant With Probiotics During Pregnancy and Neonatal Period
Status: COMPLETED
Conditions: Atopic Dermatitis|Allergic Rhinitis|Asthma
Interventions: DIETARY_SUPPLEMENT: Lactobacillus rhamnosus GG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Addressing Gaps in the Hypertension and Diabetes Care Continuum in Rural Bangladesh: The Dinajpur Study
Status: RECRUITING
Conditions: Hypertension|Diabetes
Interventions: COMBINATION_PRODUCT: Multicomponent decentralized care|COMBINATION_PRODUCT: mHealth
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: COVID-19 Booster Incentives
Status: COMPLETED
Conditions: Booster Message|Booster Message + Financial Incentive
Interventions: BEHAVIORAL: Messaging|BEHAVIORAL: Financial Incentive|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Benralizumab in Patients With Non-cystic Fibrosis Bronchiectasis
Status: COMPLETED
Conditions: Non-cystic Fibrosis Bronchiectasis
Interventions: BIOLOGICAL: Benralizumab|BIOLOGICAL: Placebo to Benralizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Bioequivalence of Oraxol in Cancer Patients Treated With Intravenous Paclitaxel
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: HM30181 methanesulfonate monohydrate plus oral paclitaxel capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Epinastine Hydrochloride Eye Drops in the Treatment of Chinese Seasonal Allergic Conjunctivitis Patients
Status: COMPLETED
Conditions: Seasonal Allergic Conjunctivitis
Interventions: DRUG: Epinastine Hcl Oph Soln+Simulating Azelastine Hcl Oph Soln|DRUG: Azelastine Hcl Oph Sol+Simulating Epinastine Hcl Oph Soln
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prognosis Prediction System of Patients With Cardiovascular and Cerebrovascular Diseases Based on Multi-omics
Status: RECRUITING
Conditions: Coronary Artery Disease|Arrhythmias, Cardiac|Heart Valve Diseases|Aortic Dissection|Heart Neoplasms|Myocarditis|Hypertension|Cardiomyopathies|Structural Heart Disease|Ischemic Cerebrovascular Disease|Hemorrhagic Cerebrovascular Disease|Brain Neoplasms
Interventions: OTHER: Observational; No Interventions were given.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose-Escalation Study to Evaluate the Safety and Tolerability of Intravitreal vMCO-I in Patients With Advanced Retinitis Pigmentosa
Status: COMPLETED
Conditions: Retinitis Pigmentosa|Retinal Diseases|Retinal Degeneration
Interventions: BIOLOGICAL: Gene Therapy product:vMCO-I
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Healthy Volunteer Study With Inhaled GSK573719 and Placebo
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: 100mcg|DRUG: 500mcg|DRUG: 1000mcg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Study of Iliac Artery Branch Stent for Internal Iliac Artery Reconstruction in Abdominal Aortic Aneurysm/Iliac Aneurysm Repair
Status: NOT_YET_RECRUITING
Conditions: Aortic Aneurysm, Abdominal|Iliac Aneurysm
Interventions: DEVICE: IBD stent of Shenzhen Xianjian Company and IBE stent of American Gore company
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion
Status: COMPLETED
Conditions: Degenerative Disc Disease|Degenerative Spondylolisthesis|Spinal Stenosis
Interventions: BIOLOGICAL: Lumbar Interbody Fusion with Autograft|BIOLOGICAL: Lumbar Interbody Fusion with NeoFuse|BIOLOGICAL: Lumbar Interbody Fusion with NeoFuse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of an Educational Story to Prepare Children With Developmental Disabilities for Sleep Study
Status: COMPLETED
Conditions: Developmental Disabilities|Sleep Disorders|Polysomnography|Preparation for Medical Procedure|Child
Interventions: OTHER: Educational Story
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Therapeutic Evaluation of Low-dose IL-2-based Immunomodulatory Approach in Patients With Early AD
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: Proleukin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Demonstrate Equivalent Pharmacokinetic Properties of HD204 and Bevacizumab (Avastin®) in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: HD204|DRUG: Avastin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: A Study of r-PA Treating Patients With Acute Ischemic Stroke（RAISE）
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Injection of recombinant human tissue plasminogen kinase derivatives|DRUG: Recombinant human tissue plasminogen activator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of Two Fiber Reinforced Resin Composites Versus Nanohybrid Resin Composite in Posterior Teeth Will be Evaluated Using Modified USPHS Criteria
Status: COMPLETED
Conditions: Dental Restoration Failure
Interventions: OTHER: Short fiber resin composite|OTHER: Polyethylene ribbon fiber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Metabolic Effects of Empagliflozin in Patients With High Risk of Heart Failure
Status: RECRUITING
Conditions: Obesity|Heart Failure
Interventions: DRUG: Empagliflozin 10 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of the St Jude Medical Portico Resheathable Aortic Valve System-Alternative Access
Status: COMPLETED
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: Transaortic TAVR Implant|DEVICE: Subclavian /Axillary TAVR implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Different Filling Pressures in Operative Outpatient Hysteroscopy on the Procedure Success Rates and Associated Pain.
Status: COMPLETED
Conditions: Hysteroscopy
Interventions: DEVICE: Filling pressure 80|DEVICE: Filling pressure 60|DEVICE: Filling pressure 40
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PILI 'Āina Household
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes|Hypertension|Dyslipidemias|Overweight and Obesity
Interventions: BEHAVIORAL: PILI 'Āina|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Intervention of Spontaneous Hyperventilation in Patients With Aneurysmal Subarachnoid Hemorrhage
Status: UNKNOWN
Conditions: Hyperventilation|Aneurysmal Subarachnoid Hemorrhage|Cerebral Blood Flow
Interventions: DRUG: Remifentanil Injection [Ultiva]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Pneumatic Tourniquet Technique for Endoscopic Radial Artery Harvest; Does it Affect Patient Hemodynamics?
Status: COMPLETED
Conditions: Ischemic Heart Disease|Coronary Artery Bypass Graft
Interventions: PROCEDURE: Pneumatic tourniquet, endoscopic left radial artery harvesting
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cabergoline for Lactation Inhibition After Early Second-Trimester Abortion or Pregnancy Loss
Status: ENROLLING_BY_INVITATION
Conditions: Lactation Suppressed
Interventions: DRUG: Cabergoline 1 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Incidence of Skin Cancers in Patients With Epidermolysis Bullosa Receiving Filsuvez
Status: NOT_YET_RECRUITING
Conditions: Epidermolysis Bullosa, Dystrophic|Epidermolysis Bullosa, Junctional
Interventions: DRUG: Filsuvez
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Standard Palliative Care Versus Standard Palliative Care Plus Polychemotherapy in Metastasized Malignant Melanoma
Status: UNKNOWN
Conditions: Metastatic Melanoma
Interventions: DRUG: Cisplatin, Vindesine, Dacarbazine (drugs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Remote Ischemic Preconditioning Improve the Prognosis of Myocardial Infarction Patients With Emergency Reperfusion Therapy
Status: UNKNOWN
Conditions: Myocardial Infarction, Acute
Interventions: OTHER: remote ischemic preconditioning （RIPC）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Efficacy and Safety of Neuronox and Botox With Essential Blepharospasm
Status: COMPLETED
Conditions: Essential Blepharospasm
Interventions: DRUG: Neuronox|DRUG: Botox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Evaluation of Docetaxel, Gemcitabine, and Bevacizumab Combination Followed by Bevacizumab Alone in Subjects With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: docetaxel|DRUG: gemcitabine|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Subcutaneous Mircera Once Monthly in the Treatment of Anemia in Participants With Chronic Kidney Disease Not on Dialysis
Status: COMPLETED
Conditions: Renal Anemia, Chronic
Interventions: DRUG: Methoxy polyethylene glycol-epoetin beta|DRUG: Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Silver Diamine Fluoride and Its Parental Perception
Status: SUSPENDED
Conditions: Dental Caries in Children
Interventions: DRUG: silver diamine fluoride|DRUG: MI Varnish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhanced Linkage to HIV Care Following Home-Based HIV Testing in Rural Uganda
Status: COMPLETED
Conditions: HIV
Interventions: BEHAVIORAL: Enhanced linkage to care|BEHAVIORAL: Standard-of-care plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Thoracic Epidural Administered Ropivacaine Versus Bupivacaine on Bladder Function
Status: COMPLETED
Conditions: Post Operative Urinary Retention
Interventions: DRUG: Ropivacaine 2mg/ml|DRUG: Bupivacaine|DEVICE: 6 French transurethral dual channel catheter (Gaeltec, Dunvegan, Scotland)|DEVICE: 14 French rectal balloon catheter (Gaeltec, Dunvegan, Scotland)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of BGG492 in Patients With Chronic Subjective Tinnitus
Status: COMPLETED
Conditions: Chronic Subjective Tinnitus
Interventions: DRUG: BGG492A|DRUG: BGG492A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of E-cigarettes in Current Cigarette Smokers
Status: COMPLETED
Conditions: Smoking|Nicotine Dependence|Nicotine Dependence, Other Tobacco Product
Interventions: OTHER: electronic cigarette|OTHER: cigarette group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Single and Multiple Oral Doses of TollB-001
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: TollB-001 tablets|DRUG: TollB-001 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Squat-to-Stand Maneuver With Amyl Nitrite, Valsalva, and Exercise Stress Echocardiography in Inducing Latent Left Ventricular Outflow Obstruction in Hypertrophic Cardiomyopathy
Status: WITHDRAWN
Conditions: Hypertrophic Cardiomyopathy|Hypertrophic Obstructive Cardiomyopathy|Cardiomyopathy, Hypertrophic
Interventions: OTHER: Squat-to-stand maneuver|DRUG: Amyl nitrite inhalation|OTHER: Valsalva
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Fluorodeoxyglucose Positron Emission Tomography (FDG PET) Findings in Patients With Phenylketonuria Before and After KUVAN Therapy
Status: COMPLETED
Conditions: Phenylketonuria
Interventions: DRUG: Sapropterin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Combined Effect of Omega-3 Fatty Acid and Vitamin D3 on Lipid Profile Levels and Oxidized Low Density Lipoprotein
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: VD3|DIETARY_SUPPLEMENT: omega 3- FA|DIETARY_SUPPLEMENT: VD3 and omega- 3FA|OTHER: no intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Barbed Suture vs Smooth Suture for Vaginal Cuff Closure
Status: COMPLETED
Conditions: Closure of Vaginal Cuff at Laparoscopic Hysterectomy
Interventions: PROCEDURE: Closure of vaginal cuff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of COVID-19 Vaccine in Population Aged 18 Years and Above
Status: UNKNOWN
Conditions: COVID-19
Interventions: BIOLOGICAL: low-dose LYB001|BIOLOGICAL: Recombinant COVID-19 Vaccine (CHO Cell)|BIOLOGICAL: high-dose LYB001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Stroke-induced Myocardial Dysfunction: Role of GDF-15 (SMOG-15) Clinical Work Package
Status: RECRUITING
Conditions: Ischemic Stroke
Interventions: PROCEDURE: Electrocardiogram|PROCEDURE: transthoracic echocardiography|BIOLOGICAL: standard biology|BIOLOGICAL: determination of serum GDF-15, osteoprotegerin and ST-2|BIOLOGICAL: Ultrasensitive Troponin-Ic|OTHER: Collection of clinical and radiological data|OTHER: 72-hour continuous Holter-ECG recording
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Brepocitinib in Adults With Active, Non-Infectious, Non-Anterior Uveitis
Status: NOT_YET_RECRUITING
Conditions: Uveitis, Posterior|Uveitis, Intermediate|Uveitis
Interventions: DRUG: Brepocitinib PO QD|DRUG: Placebo PO QD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optical Coherence Tomography Comparison of Neointimal Coverage Between CRE8 DES and BMS
Status: COMPLETED
Conditions: Stable Angina|Unstable Angina|NSTEMI
Interventions: DEVICE: Amphilimus Eluting Stent|DEVICE: Bare Metal Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Venglustat Tablets on Neuropathic and Abdominal Pain in Male and Female Participants ≥16 Years of Age With Fabry Disease
Status: RECRUITING
Conditions: Fabry Disease
Interventions: DRUG: Venglustat (GZ402671)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing Implementation of Delivering Community-based, Peer-led Interventions for Mental Health Problems Among Youth in Eldoret, Kenya
Status: COMPLETED
Conditions: Unspecified Behavioral and Emotional Disorders With Onset Usually Occurring in Childhood and Adolescence|Mental Disorder First Evident in Infancy, Childhood, or Adolescence|Mental Disorder of Infancy, Childhood, or Adolescence (Diagnosis)
Interventions: BEHAVIORAL: Peer delivered problem solving therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pilot Study of rhBMP-2/ACS/LT-CAGE® for Anterior Lumbar Interbody Fusion in Patients With Degenerative Disc Disease
Status: COMPLETED
Conditions: Degeneration of Lumbar Intervertebral Disc
Interventions: DEVICE: rhBMP-2/ACS/LT-CAGE® Device|DEVICE: Autograft/LT-CAGE® Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of PRN Omega-3 Nutritional Supplement on Visual Acuity
Status: UNKNOWN
Conditions: Cataract, Dry Eye Disease
Interventions: DIETARY_SUPPLEMENT: Omega-3 (Triglyceride form)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of the Combination of Crizotinib and Dasatinib in Pediatric Research Participants With Diffuse Pontine Glioma (DIPG) and High-Grade Glioma (HGG)
Status: COMPLETED
Conditions: Diffuse Intrinsic Pontine Glioma|High-grade Glioma
Interventions: DRUG: Crizotinib|DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dual-hormone Artificial Pancreas Versus Single-hormone Under Exercise and a Meal Challenge
Status: RECRUITING
Conditions: Type 1 Diabetes
Interventions: DEVICE: Automated insulin delivery system algorithm with a dual-hormone configuration (insulin and glucagon) for glucose control|DEVICE: Automated insulin delivery system with a single-hormone configuration (insulin) with rescue carbohydrate recommendations for glucose control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Diverting The Children's Attention To A Different Point During Phlebotomy
Status: COMPLETED
Conditions: Pain and Anxiety of Children During Phlebotomy
Interventions: DEVICE: Equipment to divert the focus of children
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling
Status: COMPLETED
Conditions: Hypogonadotropic Hypogonadism|Healthy Postmenopausal Women|Agonadism
Interventions: DRUG: kisspeptin 112-121|DRUG: GnRH
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Composite Resin Plus Connective Tissue Graft.
Status: COMPLETED
Conditions: Gingival Recession
Interventions: PROCEDURE: Connective tissue graft|PROCEDURE: Composite resin restoration (Filtek Supreme - 3M)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Intervention for High Risk Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Exercise Program|BEHAVIORAL: Website|BEHAVIORAL: Exercise DVD|BEHAVIORAL: Survey|BEHAVIORAL: Self-Report Assessments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Adjuvant Treatment in Elderly Patients With Periodontitis Through the Administration of a Supplement Rich in Oleuropein From the Olive Leaf
Status: RECRUITING
Conditions: Periodontitis
Interventions: DIETARY_SUPPLEMENT: Oleuropein from olive tree|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Pharmacology Study of MRA in Patient With Rheumatoid Arthritis (RA) With Renal Impairment
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: MRA(Tocilizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Urinary Uromodulin and the Corresponding Gene Expression as a Biomarker of Diabetic Nephropathy
Status: COMPLETED
Conditions: Diabetic Nephropathy
Interventions: DIAGNOSTIC_TEST: ACR, fasting, postprandial blood glucose ,HbA1c, creatinine, cystatin-C, BUN, Na, K , lipid profile
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Primary Sclerosing Cholangitis With Oral Vancomycin by the Study of Its Antimicrobial and Immunomodulating Effects
Status: COMPLETED
Conditions: Primary Sclerosing Cholangitis
Interventions: DRUG: Oral Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Food Matrix Delivery System on the Bioavailability of Vitamin D3
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|COMBINATION_PRODUCT: Whey protein-complex|OTHER: Water|OTHER: Milk|OTHER: Juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Fats on Blood Glucose in People With and Without Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Metformin vs Thiazolidinedione (Pioglitazone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Combining Neuro-Imaging and Non-Invasive Brain Stimulation for Clinical Intervention in Opioid Use Disorder
Status: COMPLETED
Conditions: Opioid-Related Disorders|Heroin Dependence|Morphine Dependence
Interventions: DEVICE: Transcranial Direct Current Stimulation (tDCS)|DEVICE: Sham Transcranial Direct Current Stimulation (tDCS)|BEHAVIORAL: Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metformin Hydrochloride in Affecting Cytokines and Exosomes in Patients With Head and Neck Cancer
Status: COMPLETED
Conditions: Larynx|Lip|Oral Cavity|Pharynx
Interventions: RADIATION: External Beam Radiation Therapy|DRUG: Metformin Hydrochloride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Parallel Bioavailability Study of Fish Oil-Ethyl Ester Versus Fish Oil-Triglyceride Versus Krill Oil
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DIETARY_SUPPLEMENT: fish oil ethyl ester|DIETARY_SUPPLEMENT: fish oil triglyceride|DIETARY_SUPPLEMENT: krill oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Study of the Combination of Axitinib Plus Everolimus in Patients With Malignant Advanced Solid Tumors
Status: COMPLETED
Conditions: Malignant Advanced Solid Tumors|Carcinoma, Renal Cell
Interventions: DRUG: Axitinib plus everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Infusion of Lidocaine in Gastroscopy
Status: UNKNOWN
Conditions: Sedation
Interventions: DRUG: placebo|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: RAC Pilot - The Feasibility and Effectiveness of a Brief Preventive Intervention Following Psychological Trauma
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic
Interventions: BEHAVIORAL: modified Prolonged Exposure|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telemedicine or Standard Care in Treating Patients With Depression and/or Pain Caused By Cancer
Status: UNKNOWN
Conditions: Depression|Pain|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: PROCEDURE: management of therapy complications|PROCEDURE: pain therapy|PROCEDURE: psychosocial assessment and care|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Supplementation of Infant Formula With Synbiotics
Status: COMPLETED
Conditions: Infant Formula
Interventions: OTHER: Lactobacillus paracasei paracasei strain F19
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Different Diets on Isotretinoin Users to Serum Lipid Levels
Status: RECRUITING
Conditions: Acne Cystic|Diet, Healthy
Interventions: DIETARY_SUPPLEMENT: Diet experiment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Corneal Epithelial Stem Cells and Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Syndromes|Dry Eye|Ocular Inflammation|Ocular Surface Disease|Ocular Discomfort|Blepharitis
Interventions: OTHER: Corneal Epithelial Stem Cell Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of XP19986 in Subjects With Spasticity Due to Spinal Cord Injury
Status: COMPLETED
Conditions: Muscle Spasticity
Interventions: DRUG: XP19986 SR1, 10 mg BID|DRUG: XP19986 SR1, 20 mg BID|DRUG: XP19986 SR1, 30 mg BID|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Cohort Study of Patients Suffering From Hand Osteoarthritis Symptoms
Status: RECRUITING
Conditions: Hand Osteoarthritis
Interventions: DIAGNOSTIC_TEST: Identification of subgroups of patients with early AD with risk of progression
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Eligibility Screening of Patients With Central Nervous System Tumors for the National Cancer Institute s (NCI) Clinical Research Protocols
Status: TERMINATED
Conditions: Glioblatoma|Gliosarcoma|Anaplastic Astrocytoma|Oligodendroglioma|Anaplastic Oligoastrocytoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p