pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Reduced vs Conventional Dosage Intensity-modulated Radiotherapy for Chemotherapy-sensitive Stage II-III Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma|Radiotherapy|Chemotherapy
Interventions: RADIATION: reduced dosage IMRT|RADIATION: conventional dosage IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of PRRT With 177Lu-EB-FAPI in Patients With Advanced Cholopancreatic Tumors
Status: RECRUITING
Conditions: Advanced Pancreatic Cancer and Cholangiocarcinoma
Interventions: DRUG: PRRT with 177Lu-EB-FAPI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiac (CMRI) Assessment of Acromegaly
Status: COMPLETED
Conditions: Acromegaly
Interventions: DEVICE: CMRI|DRUG: Gadolinium|PROCEDURE: OGTT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Investigate Pregnancy Outcomes in Female Participants Exposed to Subcutaneous (SC) Peginterferon Beta-1a and Intramuscular (IM) Interferon Beta-1a Reported in a German Participant Support Program
Status: COMPLETED
Conditions: Multiple Sclerosis|Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Interferon Beta Therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: In Vivo Specificity of KUC 7483 CL Co-administered With Bisoprolol, Propranolol, and Acipimox in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: KUC 7483 CL|DRUG: Bisoprolol|DRUG: Propranolol|DRUG: Acipimox|DRUG: Salmeterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Symbicort Turbuhaler in Chinese Patients With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: budesonide/formoterol (Symbicort)|DRUG: budesonide (Pulmicort)|DRUG: terbutaline sulfate (Bricasol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cat Pilot Study - Environmental Exposure Chamber (EEC) vs. Nasal Allergen Challenge (NAC)
Status: COMPLETED
Conditions: Hypersensitivity, Immediate
Interventions: PROCEDURE: Nasal Allergen Challenge|OTHER: Environmental Exposure Chamber|BIOLOGICAL: Cat allergen (FelD1)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Local, Open-Label, Extension Trial Of The Efficacy And Safety Of Fesoterodine In Elderly Patients With Overactive Bladder
Status: COMPLETED
Conditions: Urinary Bladder, Overactive
Interventions: DRUG: Fesoterodine|DRUG: Fesoterodine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotics and Capsaicin Evoked Coughs
Status: COMPLETED
Conditions: Atopic Asthma
Interventions: DIETARY_SUPPLEMENT: BioGaia-DSM17938|OTHER: Placebo Comparator: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remifentanil And Local Anesthesia Compared With Local Anesthesia For The Insertion Of Central Venous Catheters
Status: COMPLETED
Conditions: Local Anesthesia
Interventions: DRUG: Remifentanil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Myogenic and Osteogenic Responses to eXercise and Ibuprofen
Status: COMPLETED
Conditions: Aging|Physical Fitness
Interventions: DRUG: Ibuprofen|DRUG: Placebo|BEHAVIORAL: musculoskeletal-loading exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Effects on Social and Cognition Functions of Blonanserin in First Episode Schizophrenia Patients
Status: TERMINATED
Conditions: First Episode Schizophrenia|Social Function|Cognition Function|Blonanserin
Interventions: DRUG: Blonanserin|OTHER: MRI and serum BDNF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Steroids for Acute Pharyngitis.
Status: COMPLETED
Conditions: Acute Pharyngitis
Interventions: DRUG: Budesonide 0.25 MG/ML Inhalant Solution|DRUG: Dexamethasone|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mycophenolate Mofetil Versus Azathioprine for Maintenance Therapy of Lupus Nephritis.
Status: COMPLETED
Conditions: Lupus Nephritis
Interventions: DRUG: Mycophenolate mofetil|DRUG: Azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cochleural Alternating Acoustic Beam Therapy (CAABT) Versus Masking Intervention for Tinnitus
Status: UNKNOWN
Conditions: Tinnitus, Subjective
Interventions: DEVICE: CAABT|DEVICE: masking therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Multicenter, Phase III Trial Comparing Treatment With R-mini-CHOP With R-mini-CHP + Polatuzumab Vedotin in Patients With Diffuse Large Cell B Cell Lymphoma
Status: RECRUITING
Conditions: DLBCL|Diffuse Large B Cell Lymphoma
Interventions: DRUG: R-pola-mini-CHP|DRUG: R-mini-CHOP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of a Vaccine Against Influenza (2010-2011 Northern Hemisphere Season, Intramuscular Route)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza virus vaccine (split virion, inactivated)|BIOLOGICAL: Influenza virus vaccine (split virion, inactivated)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Ranolazine in ALS
Status: NOT_YET_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Ranolazine|DRUG: Ranolazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral AZ-3102 in Patients With GM2 Gangliosidosis or Niemann-Pick Type C Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: GM2 Gangliosidosis|Niemann-Pick Disease, Type C
Interventions: DRUG: AZ-3102 (Dose 1)|DRUG: Placebo|DRUG: AZ-3102 (Dose 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pembrolizumab and Radiation Therapy in People With Mesothelioma
Status: RECRUITING
Conditions: Malignant Pleural Mesothelioma
Interventions: DRUG: Pembrolizumab|RADIATION: IMPRINT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Results of Neusidl Corneal Inserter in Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK)
Status: UNKNOWN
Conditions: Fuchs' Corneal Endothelial Dystrophy
Interventions: DEVICE: NCI Insertion|PROCEDURE: Standard Forceps Insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Visual Outcomes of Monovision Patients Bilaterally Implanted With Nanoflex Intraocular Lenses
Status: UNKNOWN
Conditions: Patients Who Have Bilateral NanoFlex Implantation at Least 3 Months Previously
Interventions: DEVICE: Nanoflex IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Droxidopa in the Treatment of Freezing Of Gait Symptoms in Patients With Parkinson's Disease
Status: WITHDRAWN
Conditions: Gait Disorders, Neurologic
Interventions: DRUG: droxidopa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Dexamethasone on the Time to Pain Resolution in Dental Periapical Abscess
Status: COMPLETED
Conditions: Dental Research|Pharmaceutical Preparations, Dental
Interventions: DRUG: oral dexamethasone|DRUG: Placebo Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Two-week Open-label Pharmacodynamic and Pharmacokinetic Study of Multiple Doses of a Darifenacin Liquid Oral Suspension in Children (2 - 15 Years) With Neurogenic Detrusor Overactivity
Status: TERMINATED
Conditions: Neurogenic Detrusor Overactivity
Interventions: DRUG: Darifenacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Interest of a Postural and Functional Analysis for the Follow-up of the Adapted Motor Activity of Patients Treated for Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: OTHER: Adapted motor activity
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Melanoma Detection in Switzerland With VECTRA
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: DEVICE: 3D imaging Total Body Photography Vectra® WB360|DEVICE: 2D imaging FotoFinder ATBM® Master imaging system|DEVICE: Smartphone application (SkinVision®)|OTHER: Standard-of-care clinical assessment of the skin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Org 24448 to Treat Major Depression
Status: TERMINATED
Conditions: Depression
Interventions: DRUG: Org 24448|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Discharge Planning Program for Post CABG Patients
Status: ENROLLING_BY_INVITATION
Conditions: Coronary Artery Bypass Graft Surgery|Mace|30 Day Mortality
Interventions: OTHER: Nurse led discharge planning program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Kinesio Taping and Breathing Exercises on Pain Management
Status: COMPLETED
Conditions: Postoperative Pain|Gas Bloat Syndrome|Defecation Disorders
Interventions: OTHER: Kinesio Taping|OTHER: Breathing Exercise|OTHER: Kinesio Taping+Breathing Exercise|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Relationship of Premenstrual Syndrome and Primary Dysmenorrhea With Severity of Temporomandibular Disorders
Status: NOT_YET_RECRUITING
Conditions: Primary Dysmenorrhea|Premenstrual Syndrome|Temporomandibular Disorder
Interventions: OTHER: Correlation assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study of JNJ-80948543, a T-cell Redirecting CD79b x CD20 x CD3 Trispecific Antibody, in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
Status: RECRUITING
Conditions: Lymphoma, Non-Hodgkin|Leukemia, Lymphocytic, Chronic, B-Cell
Interventions: DRUG: JNJ-80948543
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Vitamin D Supplementation on Improvement of Gums Health
Status: COMPLETED
Conditions: Gingival and Periodontal Disease|Deficiency of Vitamin D3|Pregnancy
Interventions: DRUG: Vitamin D3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Artificial Intelligence Delivered Cardiac Magnetic Resonance - Prospective Validation
Status: NOT_YET_RECRUITING
Conditions: Cardiovascular Diseases|Healthy Volunteers
Interventions: DIAGNOSTIC_TEST: AI-assisted cardiac magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of a Chemically Activated Composite Resin Alkasite With Resin Composite in Atypical Caries Lesions of Deciduous Teeth
Status: UNKNOWN
Conditions: Dental Caries in Children
Interventions: PROCEDURE: Dental Restoration with Chemically activated Composite resin Alkasite|PROCEDURE: Dental Restoration with Bulk fill resin composite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Music Therapy Protocol to Support Bulbar and Respiratory Functions in ALS
Status: UNKNOWN
Conditions: Motor Neuron Disease, Amyotrophic Lateral Sclerosis|ALS (Amyotrophic Lateral Sclerosis)|Dysarthria, Flaccid|Dysarthria, Spastic|Dysarthria, Mixed|Dysphagia|Dyspnea|Aspiration Pneumonia|Hypernasality|Breathlessness
Interventions: PROCEDURE: Music therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Subcutaneous Administration of Teplizumab in Adults With Type 1 Diabetes
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: teplizumab or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Gait Rehabilitation to Treat FastOA
Status: RECRUITING
Conditions: Anterior Cruciate Ligament Injuries|Post-traumatic Osteoarthritis|Knee Osteoarthritis|Osteo Arthritis Knee|Knee Injuries|Cartilage, Articular|Gait
Interventions: BEHAVIORAL: Real-time gait biofeedback|BEHAVIORAL: Sham real-time gait biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Effectiveness of the Optilume® BPH Catheter System in a Post-Market Study
Status: RECRUITING
Conditions: Benign Prostatic Hyperplasia
Interventions: DEVICE: Optilume® BPH Catheter System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Performance of a Single-use Intermittent Micro-hole Zone Catheter
Status: COMPLETED
Conditions: Urinary Incontinence|Retention, Urinary
Interventions: DEVICE: Investigational device - intermittent catheter with a micro-hole zone|DEVICE: Comparator device -VaPro intermittent catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Impact of Triptan and Doxycycline on Neuroinflammatory Biomarkers in Acute Migraine
Status: WITHDRAWN
Conditions: Migraine Disorders|Headache, Migraine|Migraine|Migraine Headache|Migraine With Aura|Migraine Without Aura|Headache Disorders, Primary
Interventions: DRUG: Triptan|DRUG: Doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel & Oxaliplatin in Combination With Bevacizumab as First-Line Treatment in Subjects With Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Docetaxel|DRUG: Oxaliplatin|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effects of Intensive Treatment of Periodontitis on Blood Pressure Control
Status: UNKNOWN
Conditions: Periodontitis|Hypertension
Interventions: PROCEDURE: Intensive Treatment|PROCEDURE: Dental Hygienization Treatment|DRUG: Chlorhexidine (Intensive Treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Breastfeeding Counseling Approach Involving Grandmothers (BAKED)
Status: UNKNOWN
Conditions: Breastfeeding, Exclusive|Grandmother
Interventions: OTHER: The grandmothers in the intervention group will be given breastfeeding counseling before discharge. Home monitoring will be performed in the 2nd week, 3rd and 6th months after the counseling.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of a Sequence of Specific Manual Therapy Techniques Targeting the Autonomic Nervous System in Healthy Adults
Status: RECRUITING
Conditions: Autonomic Imbalance
Interventions: PROCEDURE: Sequence of manual therapy techniques|PROCEDURE: Simulated manual therapy techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 18F-CP18 Imaging Studies for Cancer Treatment With Birinapant
Status: WITHDRAWN
Conditions: Ovarian Neoplasms|Ovarian Cancer|Fallopian Tube Neoplasms|Fallopian Tube Cancer
Interventions: DRUG: [18F]-CP18|PROCEDURE: PET/ CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Quality of Recovery Under Low or Standard Pneumoperitoneum Pressure
Status: UNKNOWN
Conditions: Quality of Recovery|Postoperative Pain|Postoperative Nausea and Vomiting|Neuromuscular Blockade
Interventions: DRUG: Pneumoperitoneum pressure 10 mmHg|DRUG: Pneumoperitoneum pressure 14 mmHg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: enzalutamide|DRUG: abiraterone acetate|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Inhibition With tDCS in Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DEVICE: High-Definition Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety, Tolerability and Pharmacokinetic Study of Multiple Rising Doses of TAK- 063 in Participants With Stable Schizophrenia and Healthy Participants
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: TAK-063|DRUG: TAK-063 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Growth Mindset Psychoeducation for Modifiable Risk Factors for CMD
Status: COMPLETED
Conditions: Depression, Anxiety
Interventions: BEHAVIORAL: Growth mindset|BEHAVIORAL: Modifiable risk factor (MRF) information|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: B-cell Depletion Using the Monoclonal Anti-CD20 Antibody Rituximab in Very Severe Chronic Fatigue Syndrome
Status: TERMINATED
Conditions: Chronic Fatigue Syndrome|Myalgic Encephalomyelitis
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of a Recombinant Protein Vaccine (NDV-3) Against S.Aureus and Candida
Status: COMPLETED
Conditions: Staphylococcal Infections|Candidiasis
Interventions: BIOLOGICAL: NDV-3 investigational vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Omija (Schisandra Chinensis) Extract in Subjects With Knee Osteoarthritis
Status: COMPLETED
Conditions: Mild Knee Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: Omija extract.|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Sequential Conditioning in Haploidentical Transplantation for Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Refractory Acute Myeloid Leukemia
Interventions: DRUG: Sequential Packaging (SET)|DRUG: Transfusion graft|DRUG: Prevention of GVHD|DRUG: Care supports|DRUG: Lymphocyte injection of prophylactic donor (PDLI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: NPH and Regular Insulin in the Treatment of Inpatient Hyperglycemia: Comparison of 3 Basal-bolus Regimens
Status: COMPLETED
Conditions: Diabetes Mellitus|Hyperglycemia
Interventions: DRUG: Once-daily Insulin|DRUG: Twice-daily Insulin|DRUG: Triple-daily Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Peginterferon Alfa-2b in HBeAg Positive Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Ypeginterferon alfa-2b|DRUG: Pegasys
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CFI-402257 in Combination With Paclitaxel in Patients With Advanced/Metastatic HER2-Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: CFI-402257|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise and Oscillatory Positive Expiratory Pressure Therapy in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DEVICE: Flutter®|DEVICE: No Flutter®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Hepatitis C Positive Livers in Hepatitis C Negative Liver Transplant Recipients
Status: ACTIVE_NOT_RECRUITING
Conditions: Liver Transplant|Hepatitis C
Interventions: DRUG: sofosbuvir/velpatasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Usage of High Flow Nasal Cannula in Preventing Desaturations in Elderly Patients Going for Lower Limb Surgeries
Status: COMPLETED
Conditions: Hypoxemia During Surgery|Atelectasis
Interventions: DEVICE: high flow nasal cannula|DEVICE: nasoprong oxyen 2Litres per minute
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effectiveness of Virtual Reality on Anxiety Reduction in Women Undergoing Elective Egg Cryopreservation.
Status: RECRUITING
Conditions: Anxiety
Interventions: DEVICE: The VR instrument - Oculus Quest 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: OrthoEvidence Trial Assessing Japanese Knowledge Updates
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: OTHER: Japanese-translated evidence summaries (Advanced Clinical Evidence report from OrthoEvidence)|OTHER: English evidence summaries (Advanced Clinical Evidence report from OrthoEvidence)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Fascia Lata Allograft Versus Subepithelial Connective Tissue Grafts in the Peri-Implant Mucosal Thickness Enhancement.
Status: COMPLETED
Conditions: Implant Tissue Failure
Interventions: PROCEDURE: Soft Tissue Enhancement around dental implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of Telemedicine Pre-anesthesia Consultation in Low-risk Anesthetic Patients Undergoing Ambulatory Surgery
Status: WITHDRAWN
Conditions: Outpatient Surgery|Telemedicine
Interventions: OTHER: TCAD (telemedicine anesthesia consultation)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: IVIG in the Treatment of Autoimmune Small Fiber Neuropathy With TS-HDS, FGFR-3, or Plexin D1 Antibodies
Status: RECRUITING
Conditions: Small Fiber Neuropathy|Autoimmune Small Fiber Neuropathy|Inflammatory Polyneuropathy|Immune-Mediated Neuropathy
Interventions: DRUG: Panzyga IVIG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety Evaluation Of Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain
Status: COMPLETED
Conditions: Bowel Dysfunction|Constipation
Interventions: DRUG: Alvimopan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib (Tarceva) and Bexarotene (Targretin) Oral Capsules in Advanced Cancers of the Aerodigestive Tract
Status: COMPLETED
Conditions: Advanced, Malignant Aerodigestive Tract Tumor (Lung, Head and Neck and Esophagus)
Interventions: DRUG: Bexarotene (Targretin®)|DRUG: Erlotinib (Tarceva™)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PEPPI Study: Identification of Women at Risk for Placental Dysfunction
Status: RECRUITING
Conditions: Pre-Eclampsia|Intrauterine Growth Restriction|Polycystic Ovary Syndrome|Iron-deficiency|Cardiovascular Diseases|Hypertensive Disorder of Pregnancy|Proteinuria in Pregnancy
Interventions: OTHER: Pre-eclampsia screening program
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of CyBorD (Cyclophosphamide, Bortezomib, Dexamethasone) Plus Daratumumab in People With Monoclonal Gammopathy of Renal Significance (MGRS)
Status: RECRUITING
Conditions: Multiple Myeloma|Monoclonal Gammopathy of Renal Significance
Interventions: DRUG: Cyclophosphamide|DRUG: Bortezomib|DRUG: Dexamethasone|DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developmental Origins of Attention Deficit Hyperactivity Disorder
Status: COMPLETED
Conditions: Inattention|Impulsivity|Anxiety
Interventions: BEHAVIORAL: Whole Food, Nutrient-Dense Dietary Intervention|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Potential of Tazarotene Foam to Cause a Reaction When Applied to the Skin and Exposed to Light on Healthy Volunteers
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Tazarotene Foam without irradiation|DRUG: Tazarotene Foam with UVA and UVB irradiation|DRUG: Tazarotene Foam with UVA, UVB, and visible light|DRUG: Vehicle Foam without irradiation|DRUG: Vehicle Foam with UVA and UVB irradiation|DRUG: Vehicle Foam with UVA and UVB and visible light irradiation|DRUG: No Treatment without irradiation|DRUG: No Treatment with UVA and UVB irradiation|DRUG: No Treatment with UVA and UVB and visible light irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Bifidobacterium Lactis CCT 7858 in Adults Using Antibiotics
Status: COMPLETED
Conditions: Surgery|Infection
Interventions: DIETARY_SUPPLEMENT: Bifidobacterium Lactis CCT7858|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Delayed-immediate Versus Delayed Breast Reconstruction in Breast Cancer Patients With Mastectomy and Radiation Therapy
Status: RECRUITING
Conditions: Breast Neoplasm Female|Complication of Radiation Therapy|Breast Implant; Complications
Interventions: PROCEDURE: Delayed-immediate reconstruction|PROCEDURE: Delayed reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Effectiveness of AA4500 in Subjects With Peyronie's Disease
Status: COMPLETED
Conditions: Peyronie's Disease
Interventions: BIOLOGICAL: AA4500|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 3D Photogrammetry Versus Commercial Scanners for Accurate Repositioning of the Maxilla for Correction of the Dentofacial Deformity.
Status: RECRUITING
Conditions: Dentofacial Deformities
Interventions: PROCEDURE: Maxillary Segment Repositioning|PROCEDURE: Maxillary Segment Repositioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pericapsular Nerve Group Block Versus Caudal Block for Postoperative Pain Management in Pediatric Hip Surgery
Status: RECRUITING
Conditions: Pain, Postoperative
Interventions: PROCEDURE: Pericapsular Nerves Group Block|PROCEDURE: Caudal Epidural Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Teclistamab|DRUG: Daratumumab|DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: Talquetamab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Organ-substituting Technologies in the Treatment of Heart and Pulmonary Failure
Status: UNKNOWN
Conditions: Acute Respiratory Distress Syndrome|Septic Shock|Sepsis
Interventions: DEVICE: Cytokine adsorber filter|DEVICE: Extracorporeal hemoperfusion cartridge
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Cohort Study for Analyzing the Effect of Gastric Cancer Surgery to the Metabolic Syndrome and Insulin Resistance
Status: WITHDRAWN
Conditions: Gastric Cancer With Metabolic Syndrome or Metabolic Disease
Interventions: PROCEDURE: subtotal gastrectomy with gastroduodenostomy|PROCEDURE: subtotal gastrectomy with Roux-en-Y gastrojejunostomy,|PROCEDURE: total gastrectomy with Rou-en-Y esophagojejunostomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sleep, Autonomic Nervous System and Cardiorespiratory Capacity in Autism Spectrum Disorders Children (APAUTRES)
Status: COMPLETED
Conditions: Autonomic Nervous System Diseases|Sleep
Interventions: OTHER: physiological explorations
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intravenous Sodium Bicarbonate Verifies Intravenous Position of Catheters in Anesthetized Children
Status: UNKNOWN
Conditions: General Anesthesia
Interventions: DRUG: Sodium bicarbonate|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination Chemotherapy Including Cisplatin, Ifosfamide, Gemcitabine, L-asparaginase, Etoposide and Dexamethasone as Treatment of Newly Diagnosed and Relapsed/Refractory Peripheral T Cell Lymphomas
Status: UNKNOWN
Conditions: Peripheral T Cell Lymphoma
Interventions: DRUG: cisplatin|DRUG: ifosfamide|DRUG: gemcitabine|DRUG: L-asparaginase|DRUG: etoposide|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Double-Blind Controlled Trial to Determine the Safety and Immunogenicity of HIV-1 MN rgp160 Immuno AG Vaccine Therapy in HIV-Infected Individuals With Greater Than or Equal to 500/mm3 CD4+ T Cells and 200-400/mm3 CD4+ T Cells
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Ritonavir|BIOLOGICAL: gp160 Vaccine (Immuno-AG)|DRUG: Stavudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: DRUG: Tirzepatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Synchronous or Sequential Radiotherapy for Advanced Esophageal Squamous Cell Carcinoma With Oligometastases.
Status: NOT_YET_RECRUITING
Conditions: Advanced Esophageal Squamous Carcinoma With Oligometastases
Interventions: RADIATION: simultaneous with radiotherapy|RADIATION: synchronous with radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Expression of Markers Related to Mitochondrial Functionality in Carcinoma of the Urinary Bladder: Comparative Retrospective Analysis Between Recurrent Tumors ("Non-responders") and Non-recurrent Tumors ("Responders") After Intravesical Treatment With Chemotherapy or Immunotherapy
Status: UNKNOWN
Conditions: Bladder Cancer
Interventions: OTHER: No intervantion on patients. retrospective study is performed on paraffin embedded tumor tissue specimens routinely collected during TURBT.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Combined Efficacy of Evicel and Tranexamic Acid on Total Knee Arthroplasty
Status: WITHDRAWN
Conditions: Arthroplasty, Replacement, Knee
Interventions: DRUG: Evicel|DEVICE: tourniquet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Bacteriophage as a Useful Immunogen in Patients With Primary Immune Deficiency Diseases (PIDD)
Status: UNKNOWN
Conditions: Primary Immune Deficiency Diseases
Interventions: BIOLOGICAL: Bacteriophage OX174
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of On-demand and Continuous Administration of Nasal Spray in the Treatment of Allergic Rhinitis
Status: RECRUITING
Conditions: Allergic Rhinitis
Interventions: DRUG: Fluticasone Nasal 50 Mcg/Inh Nasal Spray, Azelastine Nasal 140 Mcg/Inh Nasal Spray|DRUG: Fluticasone Nasal 50 Mcg/Inh Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Cetuximab Before and After Surgery in Treating Patients With Resectable Liver Metastases Caused By Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: capecitabine|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin|OTHER: study of socioeconomic and demographic variables|PROCEDURE: adjuvant therapy|PROCEDURE: neoadjuvant therapy|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Smoking Cessation Interventions for PWH in South Africa
Status: RECRUITING
Conditions: Smoking Cessation|HIV|Comorbidities and Coexisting Conditions
Interventions: DRUG: Varenicline|DRUG: Nicotine patch|DRUG: Nicotine gum|BEHAVIORAL: Intensive Behavioral Counselling|BEHAVIORAL: Peer Counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Evaluation on Height and Weight in Patients With MPS II Who Started Treatment at < 6 Years of Age
Status: ACTIVE_NOT_RECRUITING
Conditions: Hunter Syndrome
Interventions: DRUG: Elaprase for intravenous (IV) infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inflammation and Stem Cells in Diabetic and Chronic Kidney Disease
Status: SUSPENDED
Conditions: Chronic Kidney Diseases|Diabetes Mellitus|Diabetic Nephropathies
Interventions: DIETARY_SUPPLEMENT: Fisetin|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Treatment of HIV-associated Neurocognitive Disorders
Status: TERMINATED
Conditions: HIV Associated Neurocognitive Disorder (HAND)
Interventions: BIOLOGICAL: IN insulin|BIOLOGICAL: Sterile Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Of PF-06647020 For Adult Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: PF-06647020 Q3W|DRUG: fluconazole|DRUG: PF-06647020 Q2W|DRUG: PF-06647020 combined with Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Transcranial Direct Current Stimulation (tDCS) in Older Lonely Individuals
Status: RECRUITING
Conditions: Loneliness
Interventions: DEVICE: Experimental Transcranial Direct Current Stimulation (tDCS)|DEVICE: Sham Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PRO1160 for Advanced Solid and Liquid Tumors (PRO1160-001)
Status: RECRUITING
Conditions: Renal Cell Carcinoma|Nasopharyngeal Carcinoma|Non Hodgkin Lymphoma
Interventions: DRUG: PRO1160
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AEDV Registry of Primary Cutaneous Lymphoma
Status: RECRUITING
Conditions: Lymphoma, T-Cell, Cutaneous|Lymphoma, B-Cell, Marginal Zone|Lymphoma, Large B-Cell, Diffuse|Sezary Syndrome|Lymphoma, Extranodal NK-T-Cell|Lymphoma, B-Cell
Interventions: OTHER: Registry of patients (exposure is Cutaneous Lymphoma)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Virtual Reality Upper Limb Therapy for People With Spinal Cord Injury
Status: NOT_YET_RECRUITING
Conditions: Tetraplegia|Spinal Cord Injuries|Upper Extremity Paralysis
Interventions: DEVICE: Virtual Reality Upper Limb Rehabilitation Games|OTHER: Upper Limb Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Impact of Fecal Microbiota Transplantation as an Immunomodulation on the Risk Reduction of COVID-19 Disease Progression With Escalating Cytokine Storm and Inflammatory Parameters
Status: UNKNOWN
Conditions: Covid19
Interventions: DRUG: Human fecal microbiota, MBiotix HBI|DRUG: Placebo|DRUG: SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interaction Between Chlorhexidine and Fluoride
Status: COMPLETED
Conditions: Periodontal Disease|Dental Caries
Interventions: DRUG: 0.12 % chlorhexidine + 0.2 % NaF mouthrinse|DRUG: 0.2 % NaF mouthrinse|DRUG: 0.12% chlorhexidine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: AV-101 as Adjunct Antidepressant Therapy in Patients With Major Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: AV-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-Mediated COVID-19 in Adult Participants
Status: COMPLETED
Conditions: Participants With or Without Stable Co-morbidities Associated With Progression to Severe COVID-19 at Different Stages of the Protocol
Interventions: BIOLOGICAL: Ad26.COV2.S|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Radiotherapy, Carboplatin/Paclitaxel and Nivolumab for High Risk HPV-related Head and Neck Cancer
Status: COMPLETED
Conditions: Oropharynx Squamous Cell Carcinoma
Interventions: DRUG: Nivolumab|DRUG: Carboplatin|DRUG: Paclitaxel|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-Acupressure on Pain, Fatigue and Sleep Quality in Systemic Lupus Erythematosus
Status: UNKNOWN
Conditions: Sleep Disorder
Interventions: OTHER: Self-Acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate INCB099280 in Participants With Select Solid Tumors Who Are Immune Checkpoint Inhibitor Naive
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: INCB099280
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Versus Standard in Laryngopharyngeal Cancers
Status: COMPLETED
Conditions: Malignant Neoplasm of Oropharynx Stage III|Malignant Neoplasm of Larynx Stage III|Malignant Neoplasm of Hypopharynx Stage III|Malignant Neoplasm of Oropharynx Stage IVa|Malignant Neoplasm of Oropharynx Stage IVb|Malignant Neoplasm of Larynx Stage IV|Malignant Neoplasm of Hypopharynx Stage IVa|Malignant Neoplasm of Hypopharynx Stage IVb
Interventions: RADIATION: Escalated Dose|RADIATION: Standard Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Collagen Matrix Versus Collagen Membrane as Socket Seal in ARP
Status: RECRUITING
Conditions: Oral Soft Tissue Conditions
Interventions: PROCEDURE: Socket seal after alveolar ridge preservation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of GYNECARE PROSIMA* Pelvic Floor Repair System for Symptomatic Pelvic Organ Prolapse
Status: UNKNOWN
Conditions: Pelvic Organ Prolapse|Stage II-III
Interventions: PROCEDURE: Procedure: GYNECARE PROSIMA* Pelvic Floor Repair System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-ceramic Bearing in Primary Total Hip Replacement
Status: TERMINATED
Conditions: Rheumatoid Arthritis|Osteoarthritis|Post-traumatic Arthritis|Collagen Disorders|Avascular Necrosis|Traumatic Femoral Fractures|Nonunion of Femoral Fractures|Congenital Hip Dysplasia|Slipped Capital Femoral Epiphysis
Interventions: DEVICE: Pinnacle™ Acetabular System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of the Ketogenic Diet in Amyotrophic Lateral Sclerosis (ALS)
Status: TERMINATED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DIETARY_SUPPLEMENT: KetoCal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study of Jaktinib in Adults With Moderate and Severe Atopic Dermatitis
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: Jaktinib Hydrochloride Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled Corticosteroid Replacement Study - Efficacy and Safety of Ro 27-2441 (Test Drug) in Moderate Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Dual Integrin Antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT