pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)
Status: RECRUITING
Conditions: ACL Injury|Meniscus Tear|Post-traumatic Osteoarthritis
Interventions: DRUG: Montelukast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-flow Nasal Cannula Nebulization of Beta 2 Adrenergic Agonist During Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease|High-flow Nasal Cannula
Interventions: DRUG: salbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclosporine A in Patients With Small Diameter Abdominal Aortic Aneurysms
Status: UNKNOWN
Conditions: Abdominal Aortic Aneurysm,|Small Abdominal Aortic Aneurysm
Interventions: DRUG: Cyclosporine A|DRUG: Cyclosporine A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate Safety, Immunogenicity of Investigational Flu Vaccine Compared to an Approved Flu Vaccine in Children Previously Vaccinated in Trial V118_05 (NCT01964989)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Adjuvanted QIV (aQIV)|BIOLOGICAL: Non-adjuvanted QIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Enhancing Sleep Dependent Consolidation by Non-invasive Brain Stimulation
Status: COMPLETED
Conditions: Stroke|Aging
Interventions: OTHER: Non-invasive brain stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Non-Inferiority of a 12-Valent Pneumococcal Conjugate Vaccine in Healthy Children in Brazil.
Status: NOT_YET_RECRUITING
Conditions: Pneumococcal Vaccines
Interventions: BIOLOGICAL: 12-Valent Pneumococcal Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Single Dose Versus Split Dose Polyethylene Glycol-based Colonic Lavage for Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy Preparation
Interventions: DRUG: Polyethylene Glycol|DRUG: polyethylene glycol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence
Status: COMPLETED
Conditions: Nicotine|Vaping|Nicotine Vaping
Interventions: OTHER: P4M3 CA35|OTHER: P4M3 CM35|OTHER: CIG|OTHER: Smoking Abstinence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Approaches That Support Mental Health in Post-secondary Students With Adverse Childhood Experiences
Status: UNKNOWN
Conditions: Adverse Childhood Experiences|Mindfulness|Students
Interventions: BEHAVIORAL: Mindfulness-based Stress Resilience Training|BEHAVIORAL: Health Enhancement Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SAR408701 Versus Docetaxel in Previously Treated, Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Positive Metastatic Non-squamous Non-small-cell Lung Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer Metastatic
Interventions: DRUG: SAR408701|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Effect of Valsartan vs Atenolol on Pro-thrombotic State in Hypertensive Patients.
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: valsartan/atenolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: EGCG Improves Acne by Modulating Molecular Targets
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: OTHER: topical EGCG application on acne
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Functional Outcome of Laparoscopic Nerve Sparing Radical Hysterectomy
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: PROCEDURE: laparoscopic nerve-sparing radical hysterectomy-type III/C1|PROCEDURE: laparoscopic radical hysterectomy (type III/C2).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Could the Stroke Volume Variation Predict a Fluid Responsiveness in Thoracotomy?
Status: COMPLETED
Conditions: Pulmonary Neoplasm|Pulmonary Tuberculosis
Interventions: OTHER: fluid loading|PROCEDURE: thoracoscopic pulmonary lobectomy|PROCEDURE: thoracotomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the Personal Identity in Adults With Autism Spectrum Disorder Without Intellectual Deficiency
Status: COMPLETED
Conditions: Autism Spectrum Disorders
Interventions: OTHER: clinical, psychological and neuropsychological assessment|OTHER: Autobiographical memories Assessment|OTHER: Autobiographical memories assessment characteristics
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Metformin and Its Impact on the Substances Associated With NO Production in Prediabetes Patients.
Status: COMPLETED
Conditions: PreDiabetes|Impaired Fasting Glucose (IFG)|Impaired Glucose Tolerance (IGT)
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of the Action of Drugs in the Body and Safety of N8 and Advate® in Haemophilia A Subjects
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A
Interventions: DRUG: Advate®|DRUG: turoctocog alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Insulin Tregopil (IN-105) With Insulin Aspart in Type 2 Diabetes Mellitus Patients
Status: COMPLETED
Conditions: Type2 Diabetes Mellitus
Interventions: DRUG: Insulin Tregopil|DRUG: Insulin Aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Electrotherapy in Subacromial Impingement Syndrome
Status: UNKNOWN
Conditions: Shoulder Impingement Syndrome
Interventions: PROCEDURE: Medium-wave 448 kHz therapy|PROCEDURE: Ultrasonic therapy|PROCEDURE: Inactive electrotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effects of Berberine Hydrochloride and Bifidobacterium in Prediabetes Prevention and Treatment
Status: WITHDRAWN
Conditions: Prediabetes
Interventions: DRUG: Bifidobacterium viable pharmaceutics|DRUG: Berberine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vitamins, Breastmilk HIV Shedding, and Child Health
Status: COMPLETED
Conditions: Maternal and Child Health Outcomes
Interventions: DIETARY_SUPPLEMENT: Vitamin A alone|DIETARY_SUPPLEMENT: Multivitamins excluding vitamin A|DIETARY_SUPPLEMENT: multivitamins including vitamin A|OTHER: Placebo
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Effectiveness of TactiCath™ Contact Force, Sensor Enabled™ (TactiCath SE) Catheter for Ablation of Drug Refractory, Symptomatic, Persistent Atrial Fibrillation
Status: COMPLETED
Conditions: Persistent Atrial Fibrillation
Interventions: DEVICE: TactiCath™ Contact Force Ablation Catheter, Sensor Enabled™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Do Patients Want to Engage in Discussions Dedicated to Anticipating (DDA) Their Preferences of Care in the Event of Worsening Health Status?
Status: UNKNOWN
Conditions: Neoplasm Metastasis|Locoregional Neoplasm|Advanced Cancer
Interventions: BEHAVIORAL: Dedicated Discussions on Anticipating preferences of care in the event of Aggravation (DDA)|OTHER: Autonomy Preference Index (API ) questionnaire - Information|OTHER: anxiety and depression (HADS) questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of 308-nm Excimer Laser for Primary Localized Cutaneous Amyloidosis Treatment in Asians
Status: UNKNOWN
Conditions: Lichen Amyloidosis
Interventions: RADIATION: 308-nm excimer laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Contact PVI Study: Use of Tissue Contact Data to Guide Atrial Fibrillation Ablation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: ablation|PROCEDURE: RF ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Lanreotide Treatment in Acromegalic Patients With Macroadenomas
Status: UNKNOWN
Conditions: Acromegaly
Interventions: DRUG: Preoperative lanreotide treatment|PROCEDURE: Transsphenoidal surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ripasudil for Enhanced Corneal Clearing Following Descemet Membrane Endothelial Keratoplasty in Fuchs' Dystrophy
Status: RECRUITING
Conditions: Fuchs Endothelial Dystrophy
Interventions: DRUG: Glanatec|DRUG: Optive, Ophthalmic Solution|PROCEDURE: Descemet Membrane Endothelial Keratoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics and Pharmacodynamics of Single Rising Doses Oral BIRB 796 BS in Healthy Human Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIBR 796 BS|DRUG: Placebo|OTHER: high fat standardized breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Decidua Stroma Cells for Steroid Resistent Acute Graft-versus-host Disease After Allo-HSCT
Status: RECRUITING
Conditions: GVHD, Acute
Interventions: BIOLOGICAL: Decidua Stroma Cells (DSC)|DRUG: Best available Treatment (BAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Term Anti-aRrhythmic Therapy for Post-Operative AF in Cardiac Surgery Patients Pilot Trial
Status: RECRUITING
Conditions: Atrial Fibrillation New Onset
Interventions: DRUG: Amiodarone Hydrochloride 200 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Energy Metabolism in Thyroidectomized Patients
Status: COMPLETED
Conditions: Thyroid Goiter|Hypothyroidism|Thyroid Cancer
Interventions: DRUG: Levothyroxine|DRUG: Liothyronine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Floxuridine and Dexamethasone as a Hepatic Arterial Infusion and Bevacizumab in Treating Patients With Primary Liver Cancer That Cannot be Removed by Surgery
Status: COMPLETED
Conditions: Liver Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: dexamethasone|DRUG: floxuridine|GENETIC: protein expression analysis|OTHER: flow cytometry|OTHER: immunoenzyme technique|OTHER: immunohistochemistry staining method|OTHER: immunologic technique|OTHER: laboratory biomarker analysis|PROCEDURE: dynamic contrast-enhanced magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Respiratory Muscle Training in Interstitial Lung Patients
Status: UNKNOWN
Conditions: Interstitial Lung Disease
Interventions: OTHER: Conventional Chest Physiotherapy|OTHER: Inspiratory Muscle Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telephone Therapeutic Education Program in DM2 Patients With Poor Metabolic Control
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Therapeutic education by phone|OTHER: Therapeutical education traditional
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion
Status: COMPLETED
Conditions: Stroke, Acute
Interventions: DRUG: Tenecteplase|DRUG: Antiplatelet treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Shear and Pressure Reducing Insoles for the Diabetic Foot
Status: COMPLETED
Conditions: Diabetes|Ulceration|Amputation|Foot Deformity|Neuropathy
Interventions: DEVICE: pressure reducing insole|DEVICE: GlideSoft®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: Adaptive ChemoTherapy for Ovarian Cancer in Patients With Replased Platinum-sensitive High Grade Serous or High Grade Endometrioid Ovarian Cancer
Status: RECRUITING
Conditions: Ovarian Cancer|Relapsed Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Cancer|Endometrioid Carcinoma|High Grade Serous Carcinoma|Ovary Cancer
Interventions: DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating The Safety Of PF-05280014 And Trastuzumab In Healthy Male Volunteers (REFLECTIONS B327-06)
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: PF-05280014|BIOLOGICAL: Herceptin®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Eslicarbazepine Acetate (BIA 2 093) as Therapy for Refractory Partial Seizures in Children
Status: COMPLETED
Conditions: Partial Epilepsy in Children and Adolescents
Interventions: DRUG: Eslicarbazepine acetate (BIA 2-093)|DRUG: Eslicarbazepine acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Detection of ISUP≥2 Prostate Cancers Using Multiparametric MRI: Prospective Multicenter Comparison of the PI-RADS Score and an Artificial Intelligence System
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: Blood sample|OTHER: Follow up questionnaire|DIAGNOSTIC_TEST: Human reading of prostate MR images (PI-RADSv2.1).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ferric Carboxymaltose Treatment to Improve Fatigue Symptoms in Iron-deficient Non-anaemic Women of Child Bearing Age
Status: COMPLETED
Conditions: Iron Deficiency
Interventions: DRUG: Ferinject|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Advancing Mobility and Socialization in Toddlers With Disabilities: Modified Toy Cars Training With Different Postures
Status: COMPLETED
Conditions: Children With Mobility Disabilities
Interventions: BEHAVIORAL: Ride-On Cars with Standing Posture (ROC-Stand)|BEHAVIORAL: Ride-On Cars with Standing Postures (ROC-Sit)|BEHAVIORAL: Regular Therapy Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Introduction of a Colorectal Bundle in Left Sided Colorectal Resections
Status: COMPLETED
Conditions: Colorectal Disorders|Surgery--Complications|Colorectal Cancer|Anastomotic Leak|Complication of Surgical Procedure
Interventions: PROCEDURE: Colorectal Bundle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Pea Proteins With Different Degrees of Processing on Postprandial Metabolism in Healthy Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Plasma Amino Acid Appearance and Disappearance|Postprandial Metabolic Events
Interventions: OTHER: Pea protein concentrate|OTHER: Pea protein isolate|OTHER: Pea protein extrudate|OTHER: Whey protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Medication Safety and Contraceptive Counseling for Reproductive Aged Women With Psychiatric Conditions
Status: UNKNOWN
Conditions: Mental Disorders|Contraception|Chemical Teratogen Exposure
Interventions: BEHAVIORAL: 1-on-1 counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CAVE-2 GOIM Study: a Clinical Study of the Combination of Avelumab Plus Cetuximab as Rechallenge Strategy
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Cetuximab|DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Monocenter, Open-Label Glucose Clamp Study Examining the Metabolic Effect of Insulin Infusion Intervals for Basal Insulin Infusion in Patients With Type I Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus Type 1
Interventions: DEVICE: Accu-Chek Spirit Insulin Pump|DEVICE: Comparator insulin pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacology of Mupirocin in Nasal Application in Healthy Volunteers: Monocentric Study
Status: RECRUITING
Conditions: Healthy|Staphylococcus Aureus Infection
Interventions: DRUG: Mupirocin (50 mg)|DRUG: Mupirocin (500 mg)|BIOLOGICAL: blood samples after Single dose part|DIAGNOSTIC_TEST: nasal swab after Single dose part|OTHER: Collection of urine after Single dose part|DIAGNOSTIC_TEST: nasal swab during Repeated dose part|OTHER: Collection of urine during Repeated dose part|OTHER: nasal swab after Repeated dose part
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impact of Mitral Regurgitation on Coronary Haemodynamics and Instantaneous Effect of Transcatheter Mitral Valve Repair
Status: ACTIVE_NOT_RECRUITING
Conditions: Mitral Valve Insufficiency|Coronary Stenosis|Mitral Regurgitation|Coronary Artery Disease
Interventions: PROCEDURE: Measure of hemodynamic indices in a stenosed coronary artery using a pressure wire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: SHR-1210 in Combination With Apatinib and Chemotherapy in Patients With Advanced Esophageal Squamous Cell Cancer
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: SHR-1210|DRUG: Apatinib|DRUG: Irinotecan Injection|DRUG: Paclitaxel liposome|DRUG: Nedaplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MK0507A Clinical Study in Patients With Glaucoma and Ocular Hypertension (0507A-149)(COMPLETED)
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: dorzolamide hydrochloride (+) timolol maleate|DRUG: Comparator: timolol maleate|DRUG: Comparator: dorzolamide hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First-in-man Clinical Trial of CEB-01 PLGA Membrane in Recurrent or Locally Advanced Retroperitoneal Soft Tissue Sarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Soft Tissue Sarcoma|Recurrent Soft Tissue Sarcoma
Interventions: DRUG: CEB-01 membrane loaded with SN-38
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACURATE Neo™ AS Aortic Bioprosthesis for Implantation Using the ACURATE neoTM AS TF Transfemoral Delivery System in Patients With Severe Aortic Stenosis
Status: COMPLETED
Conditions: Aortic Stenosis
Interventions: DEVICE: Transcatheter aortic valve replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VRD as Induction Followed by VR Maintenance in Patients With Newly Diagnosed High Risk Multiple Myeloma
Status: RECRUITING
Conditions: Myeloma|Newly Diagnosed|High Risk
Interventions: DRUG: bortezomib|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study In Adults And Adolescents With Irritant (Non-Allergic) Rhinitis
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial
Interventions: DRUG: Fluticasone Furoate Nasal Spray|OTHER: Placebo Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TXA Nebulization for the Treatment of Hemoptysis
Status: RECRUITING
Conditions: Hemoptysis
Interventions: DRUG: TXA Nebulization|OTHER: 0.9% NS Nebulization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of SIBP-03 in Patients With Head and Neck Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: HER3 Monoclonal antibodies-Dose A|DRUG: HER3 Monoclonal antibodies-Dose B|DRUG: HER3 Monoclonal antibodies-Dose C|OTHER: HER3 Monoclonal antibodies-Dose D|OTHER: Placebo|COMBINATION_PRODUCT: Cetuximab injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gabapentin as an Adjunct to Paracervical Block for Perioperative Pain Management
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Gabapentin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MIBG Scintigraphy and Strain Echocardiography in the Detection of Subclinical Cardiovascular Effects One Year After (Neo)Adjuvant Breast Cancer Treatment With Docetaxel, Doxorubicin and Cyclophosphamide (TAC): a Pilot Study
Status: UNKNOWN
Conditions: Breast Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Radiation Therapy and Chemotherapy in Treating Patients With Stage I Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: cisplatin|DRUG: 5-fluorouracil|DRUG: Mitomycin|RADIATION: Three-Dimensional Conformal Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aripiprazole Lauroxil for Preventing Psychotic Relapse After an Initial Schizophrenia Episode
Status: TERMINATED
Conditions: Schizophrenia|Schizoaffective Disorder, Depressive Type|Schizophreniform Disorder
Interventions: DRUG: Aripiprazole Lauroxil|DRUG: ARI-ORAL|DRUG: AL-NCD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Threshold Response of Lumbar Selective Nerve Root Block in Predicting Good Outcome Following Lumbar Foraminotomy
Status: TERMINATED
Conditions: Back Pain|Radiculopathy Lumbar|Degenerative Lumbar Spinal Stenosis
Interventions: DRUG: Selective Nerve Root Block
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Self-management in Type 2 Diabetes Patients Using the Few Touch Application
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DEVICE: Use of Few Touch Application (FTA)|DEVICE: Use of FTA and health counseling based on TTM and CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase IIa Randomized Placebo Controlled Clinical Study of Codivir in Hospitalized Patients With Moderate COVID-19
Status: RECRUITING
Conditions: COVID-19
Interventions: DRUG: Covidir injections|DIAGNOSTIC_TEST: Quantitative PCR SARS-CoV-2|DIAGNOSTIC_TEST: IgM and IgG dosage|DIAGNOSTIC_TEST: Screening Blood tests|DIAGNOSTIC_TEST: Electrocardiogram|OTHER: NEWS-2 score|OTHER: WHO score|OTHER: Physical examination|OTHER: COVID-19-Related Symptoms assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Clinical Research of Low Intensity Continuous Ultrasonic on Lower Limb Arteriosclerosis Occlusion（ASO） Syndrome
Status: UNKNOWN
Conditions: Arteriosclerosis
Interventions: OTHER: Conventional conservative treatment|DEVICE: therapeutic ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adaptive Interventions for Prevention/Intervention for Youth Substance Abuse
Status: COMPLETED
Conditions: Substance Use
Interventions: BEHAVIORAL: Push Notifications with Tailored Intervention Content|BEHAVIORAL: Push Notifications with Engaging, Non-therapeutic Content|BEHAVIORAL: No Push Notifications
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Motivational Interviewing Tailored Intervention for Patients With Heart Failure (MITI-HF)
Status: COMPLETED
Conditions: Heart Failure
Interventions: BEHAVIORAL: Motivational Interviewing tailored intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Title: Recombinant Plague Vaccine rF1V in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: rFIV vaccine|BIOLOGICAL: rF1V vaccine|BIOLOGICAL: rF1V vaccine|BIOLOGICAL: rF1V vaccine 160 mcg given on Study Days 0, 56, 182
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Action Observation and Motor Imagery Therapy in Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson's Disease
Interventions: OTHER: Action observation and motor imagery therapy for rehabilitation|OTHER: Sham action observation and motor imagery therapy for rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CYP2B6 Genetics and Drug Interactions in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Efavirenz|DRUG: Bupropion|DRUG: Rosuvastatin|DRUG: Montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose-finding Study of OPC-6535 in Patients With Active Ulcerative Colitis
Status: TERMINATED
Conditions: Colitis, Ulcerative
Interventions: DRUG: OPC-6535(Tetomilast)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The ORANGE II PLUS - Trial: Open Versus Laparoscopic Hemihepatectomy
Status: UNKNOWN
Conditions: Liver Lesions Requiring Hemihepatectomy
Interventions: PROCEDURE: Open or Laparoscopic left hemihepatectomy|PROCEDURE: Open or Laparoscopic right hemihepatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Pioglitazone on Cardiac Function and Large Arteries (PICCOLA Study)
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Double Blind Placebo Controlled Study on the Effect of Extracorporal Shock Wave Therapy on Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DEVICE: "MEDISPEC" treatment probe|DEVICE: "MEDISPEC" Sham Probe|DEVICE: "MEDISPEC" Low intensity shock waves|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of an Alcohol Based Hand Gel for the Reduction of Warts on the Hands
Status: COMPLETED
Conditions: Papillomavirus Infections|Warts|Condylomata Acuminata|Epidermodysplasia Verruciformis
Interventions: OTHER: PURELL VF481|OTHER: Placebo Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Glutathione Supplementation in Older Healthy Adults and Its Effect on the Number of Healthy Days Experienced During Four Months of Supplementation Compared to Placebo
Status: COMPLETED
Conditions: Improvement in Immune Cell Function in Elderly Humans
Interventions: DIETARY_SUPPLEMENT: Setria glutathione supplement|DIETARY_SUPPLEMENT: Crystalline Cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Chinese Herbal Formulation PHY906 and Sorafenib Tosylate in Treating Patients With Advanced Liver Cancer
Status: COMPLETED
Conditions: Adult Primary Hepatocellular Carcinoma|Advanced Adult Primary Liver Cancer|Advanced Adult Hepatocellular Carcinoma|BCLC Stage B Adult Hepatocellular Carcinoma|BCLC Stage C Adult Hepatocellular Carcinoma
Interventions: DIETARY_SUPPLEMENT: Chinese herbal formulation PHY906|DRUG: sorafenib tosylate|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Cellular Heterogeneity in Patients With Mastocytosis
Status: NOT_YET_RECRUITING
Conditions: Mastocytosis
Interventions: GENETIC: scRNAseq|PROCEDURE: two Skin biopsies|PROCEDURE: one Skin biopsies
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Does Straight Catheterization in Short Gynecologic Procedures Cause Bacteriuria?
Status: UNKNOWN
Conditions: Postoperative Bacteriuria
Interventions: PROCEDURE: Straight catheterization|PROCEDURE: No straight catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Proximal Versus Distal Segments of No-Touch Saphenous Vein Grafts
Status: UNKNOWN
Conditions: Leg Wound Complication After No-Touch Harvestingof Veins
Interventions: PROCEDURE: Proximal and distal segment of saphenous vein harvested by No-Touch technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study to Evaluate Safety and Immunogenicity of AERAS 404 Administered in Adults
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: AERAS-404|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rapid Evaluation of Innovative Intervention Components to Maximize the Health Benefits of Behavioral Obesity Treatment Delivered Online: An Application of Multiphase Optimization Strategy
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: BEHAVIORAL: Online Behavioral Weight Loss Program|BEHAVIORAL: Virtual Reality for Behavioral Weight Loss Skills Training|BEHAVIORAL: Tailored Interactive Video Feedback|BEHAVIORAL: Tailored Intervention for Structured Physical Activity|BEHAVIORAL: Skills Training for Dysregulated Eating|BEHAVIORAL: Platform for Social Support & Friendly Competition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Posttraumatic Stress Disorder Treatment: Prolonged Exposure (PE) Versus PE Plus Sertraline
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Prolonged exposure (PE)|OTHER: PE plus Sertraline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Use of Hyaluronic Acid in Multiple Coronally Advanced Flap
Status: RECRUITING
Conditions: Gingival Recession, Generalized
Interventions: DEVICE: Local application of a HA gel for the treatment of MAGRs with mCAF technique and XCM|PROCEDURE: Treatment of MAGRs with mCAF technique and XCM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced Malignancies
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer|Squamous Cell Carcinoma of the Head and Neck|Breast Cancer|Colorectal Cancer|Melanoma|Bladder Cancer|Ovarian Cancer|Endometrial Cancer|Merkel Cell Carcinoma|GastroEsophageal Cancer|Renal Cell Carcinoma|Castration-resistant Prostate Cancer
Interventions: DRUG: Etrumadenant|DRUG: Zimberelimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxytocin Add-on for Stable Depressed Patients
Status: TERMINATED
Conditions: Major Depressive Disorder|Dysthymia Disorder
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Risk Assessment and Dynamic Monitoring-based Prevention Trial
Status: RECRUITING
Conditions: Cardiovascular Diseases
Interventions: OTHER: Frequent and automatic cardiovascular risk assessment|OTHER: Dynamic risk monitoring|OTHER: Regular GP visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Stereotactic Body Radiotherapy for Osseous Low Alpha-Beta Resistant Metastases for Pain Relief
Status: UNKNOWN
Conditions: Bone Metastases|Prostate Cancer|Breast Cancer|Renal Cell Carcinoma|Melanoma
Interventions: RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Focused Ultrasound Neuromodulation for Treatment of Temporal Lobe Epilepsy
Status: WITHDRAWN
Conditions: Low Intensity Ultrasound Pulsarions
Interventions: DEVICE: BX Pulsar 1002
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Prenatal Screening, Diagnosis and Intrauterine Intervention of Fetal Abnormal Chromosome and Structure in Twins Pregnancy
Status: UNKNOWN
Conditions: Chromosome Abnormality|Twin Pregnancy With Antenatal Problem
Interventions: PROCEDURE: Fetal Selective Reduction Technology|DRUG: Potassium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: to Explore the Influence of Longitudinal Muscle on the Prognosis of Achalasia Patients After Peroral Endoscopic Myotomy (POEM)
Status: UNKNOWN
Conditions: Esophageal Achalasia
Interventions: PROCEDURE: POEM preserving longitudinal muscle|PROCEDURE: POEM involving longitudinal muscle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Transdermal or Oral Telapristone Acetate in Treating Patients Undergoing Mastectomy
Status: COMPLETED
Conditions: BRCA1 Mutation Carrier|BRCA2 Mutation Carrier|Ductal Breast Carcinoma In Situ|Lobular Breast Carcinoma In Situ|Stage 0 Breast Cancer|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer
Interventions: DRUG: Telapristone Acetate|OTHER: Placebo|DRUG: Telapristone Acetate|OTHER: Placebo|OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Customized and Standard Facemasks for Early Treatment of Class III Malocclusion
Status: NOT_YET_RECRUITING
Conditions: Malocclusion, Angle Class III|Extraoral Traction Appliances
Interventions: DEVICE: Customized facemask|DEVICE: Standard facemask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Anti-Adhesion Product in the Prevention of Intraperitoneal Adhesions
Status: COMPLETED
Conditions: Intraperitoneal Adhesions
Interventions: BIOLOGICAL: Anti-Adhesion Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Gut Microbiome Modification Through Dietary Intervention in Patients With Colorectal Cancer: Response to Surgery
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: OTHER: Dietary pattern : High-fiber diet rich in PUFA|OTHER: Dietary pattern: Standard diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Aflibercept Injection for the Treatment of Submacular Vascularized Pigment Epithelial Detachment
Status: COMPLETED
Conditions: Submacular Vascularized Pigment Epithelial Detachments
Interventions: DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRX-00023 Therapy in Localization-Related Epilepsy
Status: TERMINATED
Conditions: Epilepsy|Epilepsy, Temporal Lobe|Partial Epilepsy
Interventions: DRUG: PRX-00023|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Fourth Dose Study in Australia
Status: WITHDRAWN
Conditions: COVID-19
Interventions: BIOLOGICAL: Tozinameran|BIOLOGICAL: Elasomeran|BIOLOGICAL: Tozinameran|BIOLOGICAL: Elasomeran|BIOLOGICAL: Bivalent Pfizer-BioNTech|BIOLOGICAL: Bivalent Moderna|BIOLOGICAL: Bivalent Pfizer-BioNTech|BIOLOGICAL: Bivalent Moderna
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase IV Study of Huazhi Rougan Granule in the Treatment of Non-alcoholic Simple Fatty Liver
Status: COMPLETED
Conditions: Efficacy and Safety
Interventions: DRUG: Huazhi Rougan granule
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Label Study of L059 (Levetiracetam) in Japanese Epilepsy Subjects With Generalized Tonic-clonic Seizures
Status: COMPLETED
Conditions: Epilepsy|Generalized Tonic-clonic Seizures
Interventions: DRUG: Levetiracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of SU011248 Plus Paclitaxel Versus Bevacizumab Plus Paclitaxel In Patients With Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Sunitinib|DRUG: paclitaxel|DRUG: bevacizumab|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closed Loop DBS Implanted RC+S Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: STN alone|DEVICE: GPi alone|DEVICE: STN + GPi|DEVICE: Closed-loop stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemoradiotherapy Followed by Surgery for Advanced Paranasal Sinus Cancer
Status: WITHDRAWN
Conditions: Paranasal Sinus Neoplasms
Interventions: DRUG: cisplatin|PROCEDURE: targeted radiation therapy|PROCEDURE: tumor resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of FolateScan (Technetium Tc 99m EC20) in Women With Suspected Ovarian or Endometrial Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Endometrial Cancer
Interventions: DRUG: Tc 99m EC20
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neoantigen Vaccine Plus Anti-PD1 and Chemotherapy as an Adjuvant Therapy for Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer|Adjuvant Therapy
Interventions: DRUG: Neoantigen Vaccine Plus Anti-PD1 and Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Cost-effectiveness of Fluoride Varnish Versus Resin Based Sealant (Part 2)
Status: UNKNOWN
Conditions: Cost Effectiveness
Interventions: DEVICE: Fluoride varnish (3M Clinpro White Varnish 5% sodium fluoride).|DEVICE: Resin based fissure sealant (3M Clinpro Sealant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Cannabidiol in Alcohol Use Disorder
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: OTHER: Placebo|DRUG: Phytocannabinoid cannabidiol (CBD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Post Market Clinical Follow-up Study on Biomet Microfixation HTR PEKK (Midface), Facial & Mandibular Plates.
Status: COMPLETED
Conditions: Tumor|Facial Fracture|Mandibular Fractures|Fibrous Dysplasia|Osteoma of Mandibular Condyle|Neuroma|Cleft Face|Hemifacial Microsomia|Treacher Collins Syndrome|Miller Syndrome|Nager Syndrome
Interventions: DEVICE: Titanium Facial Plates|DEVICE: Titanium Mandibular Plates|DEVICE: Add-on Condyle|DEVICE: HTR-PEKK
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess Safety and Feasibility of Direct Infusions of Donor-derived Virus-specific T-cells in Recipients of Hematopoietic Stem Cell Transplantation With Post-transplant Viral Infections Using the Cytokine Capture System®
Status: RECRUITING
Conditions: Adenovirus Infection|EBV|Cytomegalovirus Infections|Cytokine Capture System|Allogenic Disease
Interventions: BIOLOGICAL: IFN-γ positive selected T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Follow on Formula With Lactobacillus Fermentum on the Incidence of Infections
Status: COMPLETED
Conditions: Incidence of Infectious Diseases
Interventions: DIETARY_SUPPLEMENT: Lactobacillus fermentum|DIETARY_SUPPLEMENT: Follow on formula without probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Safety and Performance of a Synthetic Tissue Sealant in Reducing Fluid Leakage in Hepatobiliary and Pancreatic Surgery
Status: COMPLETED
Conditions: Pancreatectomy|Hepatic Resection
Interventions: DEVICE: Sealing Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remimazolam in High Risk ERCP Patients
Status: NOT_YET_RECRUITING
Conditions: the Severity and Duration of Intraoperative Hypotension
Interventions: DRUG: Remimazolam|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Cyclosporine vs Steroids in DRESS
Status: ENROLLING_BY_INVITATION
Conditions: DRESS Syndrome|Drug-Induced Hypersensitivity Syndrome
Interventions: DRUG: Cyclosporine|DRUG: Methylprednisolone and Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT