pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of Dexmedetomidine and Propofol on Pulmonary Mechanics
Status: COMPLETED
Conditions: Abnormal Respiratory Airway Resistance
Interventions: DRUG: propofol|DRUG: dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Genetic Testing Decision Aid
Status: RECRUITING
Conditions: Epithelial Ovarian Carcinoma|Pancreas Adenocarcinoma
Interventions: BEHAVIORAL: Electronic Decision Aid|BEHAVIORAL: Pre-Test Genetic Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: O6-Benzylguanine and Topical Carmustine in Treating Patients With Early-Stage IA-IIA Cutaneous T-Cell Lymphoma
Status: COMPLETED
Conditions: Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma|Stage I Mycosis Fungoides and Sezary Syndrome AJCC v7|Stage II Mycosis Fungoides and Sezary Syndrome AJCC v7
Interventions: DRUG: Carmustine|OTHER: Laboratory Biomarker Analysis|DRUG: O6-Benzylguanine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maintenance Study Including Re-induction Therapy for Patients Who Did Not Show a Clinical Effect in Study C87037 (NCT00291668)
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: Certolizumab pegol|BIOLOGICAL: Certolizumab pegol|BIOLOGICAL: Certolizumab pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of an Ingestible Sensor System to Measure PrEP Adherence in YMSM
Status: NOT_YET_RECRUITING
Conditions: Human Immunodeficiency Virus
Interventions: DEVICE: Proteus Sensor System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Fibrin Sealant Vascular Surgery Study
Status: COMPLETED
Conditions: Adjunct to Hemostasis in Vascular Surgery (Synthetic Vascular Grafts)
Interventions: BIOLOGICAL: FS VH S/D 500 s-apr, 60-seconds polymerization time|BIOLOGICAL: FS VH S/D 500 s-apr, 120-seconds polymerization time|PROCEDURE: Manual compression with surgical gauze pads
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Single Dose Trial of NNC 0155-0000-0004 in Patients With Haemophilia A
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A
Interventions: DRUG: turoctocog alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Combination Treatment With Pegasys (Peginterferon Alfa) and Copegus (Ribavirin)in Patients With Chronic Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Copegus (ribavirin)|DRUG: Copegus (ribavirin)|DRUG: peginterferon alfa-2a [Pegasys]|DRUG: peginterferon alfa-2a [Pegasys]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Female Sexual Wellness
Status: COMPLETED
Conditions: Sexuality|Sexual Dysfunction|Sexual Desire Disorder|Hypoactive Sexual Desire Disorder|Orgasmic Disorder|Pelvic Organ Prolapse|Urinary Incontinence|Interstitial Cystitis|Pelvic Floor Disorders|Female Sexual Dysfunction
Interventions: BEHAVIORAL: Vibrator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Lidocaine for Needle Insertion and Injection Pain
Status: UNKNOWN
Conditions: Needle Insertion and Injection Pain
Interventions: DRUG: Lidocaine Topical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bendamustin Hydrochloride in Patients With Soft Tissue Sarcoma (STS)
Status: COMPLETED
Conditions: Sarcoma, Soft Tissue
Interventions: DRUG: Bendamustin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correlation Between Computer Tomography Angiography and D-Dimer Level for the Diagnosis of Pulmonary Embolism
Status: COMPLETED
Conditions: D-Dimer as an Early Detector of Pulmonary Embolism
Interventions: DIAGNOSTIC_TEST: D-Dimer vs CTPA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase2a Primaquine Dose Escalation Study
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: dihydroartemisinin-piperaquine|DRUG: 0.125 mg/kg Primaquine|DRUG: 0.5 mg/kg Primaquine|DRUG: 0.25 mg/kg Primaquine|DRUG: 0.0625 mg/kg Primaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Early Supported Discharge for Post-Acute Stroke Patients in Korea
Status: UNKNOWN
Conditions: Stroke
Interventions: OTHER: Early Supported discharge with home based Rehabilitation|OTHER: Conventional rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Absorption, Metabolism, and Excretion of JNJ-38518168 After a Single Oral Dose in Healthy Male Participants.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-38518168
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study for Delay in Surgical Treatment of Traumatic Cervical Central Cord Injury in Canal Stenosis
Status: RECRUITING
Conditions: Acute Traumatic Cervical Central Cord Syndrom Injury
Interventions: PROCEDURE: Early surgery within 48 hours|PROCEDURE: Delayed surgery at 15 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of a Multi-Ingredient Dietary Supplement on Blood and Breath Alcohol Levels
Status: COMPLETED
Conditions: Alcohol Drinking
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Safety Shot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Testing Cabozantinib in Patients With Advanced Pancreatic Neuroendocrine and Carcinoid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoid Tumor|Functioning Pancreatic Neuroendocrine Tumor|Intermediate Grade Lung Neuroendocrine Neoplasm|Locally Advanced Digestive System Neuroendocrine Neoplasm|Locally Advanced Digestive System Neuroendocrine Tumor G1|Locally Advanced Lung Neuroendocrine Neoplasm|Locally Advanced Pancreatic Neuroendocrine Tumor|Locally Advanced Unresectable Digestive System Neuroendocrine Neoplasm|Low Grade Lung Neuroendocrine Neoplasm|Lung Neuroendocrine Tumor|Lung Neuroendocrine Tumor G2|Metastatic Digestive System Neuroendocrine Neoplasm|Metastatic Digestive System Neuroendocrine Tumor G1|Metastatic Lung Neuroendocrine Neoplasm|Metastatic Lung Neuroendocrine Tumor|Metastatic Pancreatic Neuroendocrine Neoplasm|Metastatic Pancreatic Neuroendocrine Tumor|Metastatic Thymic Neuroendocrine Neoplasm|Neuroendocrine Neoplasm|Neuroendocrine Tumor G2|Non-Functioning Pancreatic Neuroendocrine Tumor|Pancreatic Serotonin-Producing Neuroendocrine Tumor|Thymic Neuroendocrine Tumor|Unresectable Digestive System Neuroendocrine Neoplasm|Unresectable Digestive System Neuroendocrine Tumor G1|Unresectable Lung Neuroendocrine Neoplasm|Unresectable Pancreatic Neuroendocrine Neoplasm|Unresectable Thymic Neuroendocrine Neoplasm
Interventions: DRUG: Cabozantinib S-malate|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|OTHER: Placebo Administration|OTHER: Quality-of-Life Assessment|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sensitivity and Specificity of Serum and Salivary CYFRA21-1 in the Detection of Malignant Transformation in Oral Potentially Malignant Mucosal Lesions (Diagnostic Accuracy Study)
Status: UNKNOWN
Conditions: Oral Potentially Malignant Lesions|Oral Cancer
Interventions: DIAGNOSTIC_TEST: Enzyme Linked Immunosorbent assay (ELISA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SAFE Study: Safety of aPCC Following Emicizumab Prophylaxis
Status: RECRUITING
Conditions: Hemophilia A
Interventions: DRUG: aPCC-emicizumab|DRUG: FEIBA|DRUG: rFVIIa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating INS018_055 Administered Orally to Subjects With Idiopathic Pulmonary Fibrosis (IPF)
Status: ACTIVE_NOT_RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis (IPF)
Interventions: DRUG: INS018_055|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pain-related Evoked Potentials in Unilateral Peripheral Nerve Injuries
Status: COMPLETED
Conditions: Peripheral Nerve Injuries
Interventions: DIAGNOSTIC_TEST: Pain-related evoked potentials (PREP)|DIAGNOSTIC_TEST: Quantitative Sensory Testing (QST)|DIAGNOSTIC_TEST: Nerve conduction studies (NCS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of AKCEA-ANGPTL3-LRx (ISIS 703802) in Participants With Familial Partial Lipodystrophy (FPL)
Status: COMPLETED
Conditions: Familial Partial Lipodystrophy
Interventions: DRUG: AKCEA-ANGPTL3-LRx
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Entospletinib With Vincristine and Dexamethasone in Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)
Status: TERMINATED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Entospletinib|DRUG: Vincristine|DRUG: Dexamethasone|DRUG: CNS Prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Vaccine Generated by Autologous Dendritic Cells Pulsed With Autologous Whole Tumor Cell Lysate Treat Advanced Solid Tumor Patients With High Tumor Mutation Burden
Status: WITHDRAWN
Conditions: Advanced Cancer|Metastatic Cancer
Interventions: BIOLOGICAL: personalized DC vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT: Multi-modal Analgesia for Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Gallstones|Cholelithiasis|Pain
Interventions: DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Population Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Adult Cystic Fibrosis Patients
Status: COMPLETED
Conditions: Cystic Fibrosis|Cystic Fibrosis Pulmonary Exacerbation|Pseudomonas Aeruginosa Infection
Interventions: DRUG: Ceftolozane/Tazobactam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Mobilization in Conjunction With Exercise in Participants With a History of Chronic Ankle Instability
Status: UNKNOWN
Conditions: Ankle Sprains
Interventions: OTHER: High Velocity Low Amplitude mobilization|OTHER: Exercise protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adalimumab Dose Reduction Aiming Low Serum Concentration With Control of Disease Activity
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Dose reduction to 2mg/L|OTHER: Dose reduction to 5mg/L|DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Gammagard Liquid and rHuPH20 in PID
Status: COMPLETED
Conditions: Primary Immunodeficiency Diseases (PID)
Interventions: BIOLOGICAL: Recombinant human hyaluronidase (rHuPH20)+ immune globulin intravenous (IGIV)|BIOLOGICAL: Recombinant human hyaluronidase (rHuPH20)+ immune globulin intravenous (IGIV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy of Androxal in Controlling Blood Glucose in Men With Type-2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Secondary Hypogonadism
Interventions: DRUG: Placebo|DRUG: Androxal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determining the Utility of a Behavioral Intervention in Chronic Migraine
Status: RECRUITING
Conditions: Migraine|Headache|Migraine Disorders|Chronic Migraine|Lifestyle Factors|Headache Disorders
Interventions: BEHAVIORAL: Lifestyle Behavior Protocol|BEHAVIORAL: Sham Behavior Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Everolimus-eluting(PROMUS-ELEMENT) vs. Biolimus A9-Eluting(NOBORI) Stents for Long-Coronary Lesions
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Biolimus A9-eluting stent|DEVICE: Everolimus-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Weekly Paclitaxel and Cyclophosphamide in Metronomic Administration : Dose Escalation Study of Weekly Paclitaxel
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Paclitaxel dose escalation|DRUG: Paclitaxel|DRUG: Cyclophosphamide|BIOLOGICAL: Blood collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adebrelimab Combined With Chemotherapy and Concurrent SBRT for Neoadjuvant Treatment of Limited-stage Small Cell Lung Cancer
Status: RECRUITING
Conditions: Efficacy and Safety of Neoadjuvant Immunotherapy for Small Cell Lung Cancer
Interventions: DRUG: adebrelimab and chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Two Different Rye Bread Types in Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: OTHER: Traditional Finnish rye bread|OTHER: Low FODMAP rye bread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Ultrasound Guided Superficial, Deep Serratus Plane Blocks and Thoracic Epidural in Thoracotomy
Status: COMPLETED
Conditions: Post-thoracotomy Pain Syndrome
Interventions: PROCEDURE: Thoracic epidural analgesia , superficial serratus plane block and deep serratus plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of Autologous PRP and PPP Eye Drops in the Treatment of Ocular GVHD
Status: WITHDRAWN
Conditions: Graft-versus-host Disease
Interventions: BIOLOGICAL: PRP eye drops|BIOLOGICAL: PPP eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Handheld Ultrasound (HHUS) for Home Use in Hemophilia
Status: COMPLETED
Conditions: Joint Bleed|Hemophilia A
Interventions: DEVICE: handheld ultrasound: Philips Lumify integrated tele-ultrasound powered by Reacts collaborative platform
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Donor Umbilical Cord Blood Transplant With or Without Ex-vivo Expanded Cord Blood Progenitor Cells in Treating Patients With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, or Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Acute Biphenotypic Leukemia|Acute Lymphoblastic Leukemia in Remission|Acute Myeloid Leukemia in Remission|Chronic Myelogenous Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: Cyclophosphamide|DRUG: Cyclosporine|BIOLOGICAL: Ex Vivo-Expanded Cord Blood Progenitor Cell Infusion|DRUG: Fludarabine Phosphate|DRUG: Mycophenolate Mofetil|DRUG: Thiotepa|RADIATION: Total-Body Irradiation|PROCEDURE: Umbilical Cord Blood Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)
Status: NOT_YET_RECRUITING
Conditions: Treatment Resistant Depression
Interventions: DRUG: Psilocybin 25 mg|DRUG: Risperidone 1 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Lung Nodule Sensitivity of Stationary Chest Tomosynthesis in Patients With Known Lung Nodules
Status: COMPLETED
Conditions: Signs and Symptoms
Interventions: DEVICE: Stationary Digital Chest Tomosynthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study of Effectiveness of Liraglutide Added to High Dose Insulin in Type II Diabetics
Status: COMPLETED
Conditions: Diabetes Mellitus, Type II
Interventions: DRUG: Liraglutide|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: App-based Motivational Interviewing and Artificial Intelligence in Diabetes Management
Status: RECRUITING
Conditions: Diabetes Mellitus Type 2
Interventions: BEHAVIORAL: App-based Motivational Interviewing & Human health coaching|BEHAVIORAL: Empower+ App & Smartwatch wearable tracker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Long-Term Study to Evaluate the Safety of Asoprisnil in the Treatment of Women With Endometriosis From Study M01-398
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: Asoprisnil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose Study of GMC-252-L-Lys Salt in Healthy Subjects and Type 2 Diabetics
Status: TERMINATED
Conditions: Healthy|Type 2 Diabetes Mellitus
Interventions: DRUG: GMC-252-L-Lysine Salt|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Ultrasound-Guided Bilateral Erector Spinae Plane Block Versus Bilateral Rectus Sheath Block in Adults Undergoing Major Abdominal Surgery
Status: COMPLETED
Conditions: Pain|Postoperative
Interventions: DEVICE: Ultrasound guided Rectus sheath block vs Erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Barrier Enhancement for Eczema Prevention
Status: COMPLETED
Conditions: Eczema
Interventions: OTHER: Experimental (Doublebase Gel® or Diprobase Cream®)|OTHER: Best practice skin care advice booklet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Henry Ford Heart Score Randomized Trial: Rapid Discharge of Patients Evaluated for Possible Myocardial Infarction
Status: COMPLETED
Conditions: Chest Pain|Heart Attack|Coronary Artery Disease
Interventions: OTHER: Deferral of admission for stress test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effect of High Omega-3 Fish Intake on Lipid Peroxidation
Status: COMPLETED
Conditions: Omega-3 Fatty Acids|Lipid Peroxidation
Interventions: DIETARY_SUPPLEMENT: Omega-3 fish oil provided by salmon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Dry Needling and IASTM on Hamstring Tightness in Posterior Pelvic Tilt
Status: RECRUITING
Conditions: Hamstring Contractures
Interventions: DEVICE: Dry needling|DEVICE: IASTM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Clinical Performance of the Biofinity Contact Lens (Comfilcon A) With Two Lens Care Systems
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: comfilcon A|DEVICE: Synergi|DEVICE: Biotrue|OTHER: stenfilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Clinical One-stage Controlled Study of reSistant Arterial Hypertension for the desiGning of a personAlized Approach to Therapy
Status: RECRUITING
Conditions: Resistant Arterial Hypertension
Interventions: DIAGNOSTIC_TEST: Blood samples will be taken for pharmacokinetics and pharmacogenetics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Vortioxetine (Lu AA21004) in the Treatment of Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Vortioxetine|DRUG: Duloxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Brentuximab Vedotin, Bendamustine, and Rituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
Status: WITHDRAWN
Conditions: Diffuse Large B Cell Lymphoma|Mediastinal Large B-cell Lymphoma|Grey Zone Lymphoma|High Grade B Cell Lymphoma|Follicular Lymphoma|Marginal Zone Lymphoma|Small Lymphocytic Lymphoma
Interventions: DRUG: Brentuximab|DRUG: Bendamustine|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sigh35 and End-expiratory Occlusion Test (EEOT) for Assessing flUid Responsiveness in Critically Ill Patients Undergoing Pressure Support Ventilation
Status: RECRUITING
Conditions: Critically Ill Patients|Hemodynamic Instability|Mechanical Ventilation Pressure High
Interventions: DIAGNOSTIC_TEST: SIGH|DIAGNOSTIC_TEST: EEOT|DIAGNOSTIC_TEST: Fluid challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessment of the Safety and Effect of SAR425899 Versus Placebo for the Treatment of Non-alcoholic Fatty Liver Disease
Status: WITHDRAWN
Conditions: Non-alcoholic Steatohepatitis|Type 2 Diabetes Mellitus
Interventions: DRUG: SAR425899|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HLX07 Combination Therapy or Motherapy in Patient With Advanced Hepatocellular Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DRUG: HLX07|DRUG: HLX10|DRUG: HLX04|DRUG: lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Two School Based Interventions to Manage Anxiety in Autistic Students
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Anxiety Disorders|Emotion Regulation
Interventions: BEHAVIORAL: Zones of Regulation|BEHAVIORAL: Facing Your Fears - School Based
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Whole-body Vibration on Insulin Resistance in Obese Postmenopausal Women.
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: DEVICE: Total body vibration|OTHER: moderate restricted diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Drug-Drug Interaction (DDI) Study Between Sitaxsentan And Sildenafil, And Between Sitaxsentan And Tadalafil After Multiple Doses
Status: TERMINATED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: sitaxentan|DRUG: tadalafil|DRUG: sitaxsentan|DRUG: tadalafil|DRUG: sitaxsentan|DRUG: sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effect of Red Wine With Alcohol on Flow-mediated Dilation Versus Red Wine Without Alcohol
Status: NOT_YET_RECRUITING
Conditions: Healthy|Healthy Diet
Interventions: OTHER: red wine with alcohol|OTHER: red wine without alcohol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Hyperbaric Oxygen Therapy for Optic Neuropathies
Status: RECRUITING
Conditions: Optic Neuropathy|Glaucoma
Interventions: DEVICE: Hyperbaric Oxygen|DEVICE: Sham Hyperbaric Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Lamivudine and Zidovudine, Used Alone and Together, in HIV-Infected Patients Who Have Not Used Zidovudine in the Past
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Lamivudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Late Toxicity Following Intensity-Modulated Radiotherapy and Two Image-Guided Strategies With Corresponding Treatment Margins.
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DEVICE: Calypso beacon implant|RADIATION: moderate hypofractionation Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Auricular Acupressure Therapy for Patients With IC/BPS
Status: WITHDRAWN
Conditions: Interstitial Cystitis|Bladder Pain Syndrome|Urologic Diseases|Chronic Pain
Interventions: DEVICE: Auricular Acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Laryngeal and Esophageal EGF-r Expression in Patients With Reflux Laryngitis
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease|Chronic Laryngitis
Interventions: PROCEDURE: Biopsy of the retrocrycoid laryngeal mucosa|PROCEDURE: Biopsy of the distal esophageal mucosa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Utility of High-Fidelity Simulation In the Education and Assessment of Residents in the Recognition and Management of the Sepsis Syndrome
Status: TERMINATED
Conditions: Medical Knowledge|Clinical Performance
Interventions: OTHER: Debriefing of high-fidelity sepsis simulation scenarios|OTHER: Placebo: Debriefing of high-fidelity non-sepsis simulation scenarios
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: A Bioequivalence Study of Doxorubicin Hydrochloride Liposome Injection
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Doxorubicin Hydrochloride Liposome Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of NYX-2925 in Subjects With Neuropathic Pain Associated With Diabetic Peripheral Neuropathy
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathy
Interventions: DRUG: NYX-2925|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Show That Flutiform is Well Tolerated and Effective in the Treatment of COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Flutiform|DRUG: Formoterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Developing Anesthesia as Post Traumatic Stress Disorder (PTSD) Therapy
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Dexmedetomidine|DRUG: Propofol|DRUG: Ketamine|DRUG: Nitrous Oxide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Improving Smoking Cessation Quitlines: Pilot Study of Acceptance Therapy
Status: COMPLETED
Conditions: Smoking
Interventions: BEHAVIORAL: Acceptance Therapy (ACT)|OTHER: Cognitive Behavioral Therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of CLR Compared to Fosfomycin Trometamol in Acute Lower uUTIs
Status: COMPLETED
Conditions: Urinary Tract Infection
Interventions: DRUG: Canephron® N|DRUG: Fosfomycin trometamol|DRUG: Canephron® N-placebo|DRUG: Fosfomycin trometamol-placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: eHealth-based Bavarian Alternative Detection of Atrial Fibrillation: A Randomized Controlled Trial (eBRAVE-AF)
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DIAGNOSTIC_TEST: e-Health based strategy: PPG-based screening using a smartphone and ECG patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: This is a Study to Evaluate the Safety, Tolerability, PK and PD of IV Administered ABL301 in Healthy Adult Participants
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: ABL301|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Dose Vitamin-D Substitution in Patients With COVID-19: a Randomized Controlled, Multi Center Study
Status: COMPLETED
Conditions: Covid19|Vitamin D Deficiency|Corona Virus Infection|ARDS|Coronavirus|SARS-CoV Infection
Interventions: DRUG: Single high dose vitamin D|DRUG: Placebo|DRUG: Treatment as usual vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Efficacy and Safety Study of TAK-063 in Participants With an Acute Exacerbation of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: TAK-063 20 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Avastin (Bevacizumab) Added to a Chemotherapeutic Regimen in Patients With Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: bevacizumab [Avastin]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Management of Sleep Apnea Patients by a Clinical Nurse (Supernurse)
Status: COMPLETED
Conditions: Sleep Apnea Syndromes|Sleep Apnea|Multidisciplinary Communication|Sleep Apnea, Obstructive
Interventions: OTHER: Clinical nurse (supernurse) evaluation|OTHER: Pulmonologist evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ranolazine for Improving Symptoms of Palpitations
Status: UNKNOWN
Conditions: Ischemic Heart Disease
Interventions: DRUG: Ranolazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Appendicitis
Interventions: DRUG: Augmentin + Gentamicin|PROCEDURE: Appendectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)
Status: COMPLETED
Conditions: Stroke|Secondary Prevention
Interventions: DRUG: optional ASA as comedication|DRUG: placebo to ASA|DRUG: placebo to optional ASA as comedication|DRUG: placebo to dabigatran etexilate|DRUG: ASA 100 mg|DRUG: dabigatran etexilate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Blood Pressure Management on Cardiovascular AdveRse Events After Major Abdominal Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Complication
Interventions: OTHER: Intensive intraoperative blood pressure management|OTHER: Conventional intraoperative blood pressure management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Coronally Advanced Flap and Semilunar Incision Vestibular Technique for Multiple Gingival Recessions in Maxillary Teeth - A Randomized Controlled Trial
Status: UNKNOWN
Conditions: Gingival Recession, Generalized|Root Coverage
Interventions: PROCEDURE: comparison of coronally advanced flap and semilunar vestibular incision technique for root coverage in maxillary teeth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Two Brands of Hydrocortisone Injected Intramuscularly Into Deltoid and Thigh Muscles
Status: UNKNOWN
Conditions: Addison's Disease
Interventions: DRUG: Solu-Cortef 100 MG Injection|DRUG: Hydrocortisone 100mg/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Alirocumab (REGN727/SAR236553) in Patients With Heterozygous Familial Hypercholesterolemia (HeFH) Undergoing Low-density Lipoprotein (LDL) Apheresis Therapy
Status: COMPLETED
Conditions: Heterozygous Familial Hypercholesterolemia
Interventions: DRUG: Placebo|DRUG: Alirocumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reduction of Intravenous Antibiotics In Neonates
Status: COMPLETED
Conditions: Neonatal Infection|Neonatal SEPSIS
Interventions: DRUG: Amoxicillin Clavulanate|DRUG: Antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation (rTMS) in Amyotrophic Lateral Sclerosis
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: PROCEDURE: Real rTMS of the brain|PROCEDURE: Sham rTMS of the brain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 40 Hz Light Neurostimulation for Patients With Depression (FELIX)
Status: RECRUITING
Conditions: Major Depressive Disorder|Treatment Resistant Depression
Interventions: DEVICE: Neurostimulation System (NSS): Active Setting|DEVICE: Neurostimulation System (NSS): Sham Setting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Clinical Program Optimization of Inactive Hepatitis B Surface Antigen (HBsAg) Carriers (IHCs)
Status: RECRUITING
Conditions: Chronic Hepatitis B
Interventions: BEHAVIORAL: continuous treatment|BEHAVIORAL: pulse therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Metamizol in Patients With Episodic Moderate Headache
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: DRUG: Metamizol|DRUG: Acetylsalicylic acid (ASA)|DRUG: Metamizol placebo|DRUG: ASA placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone Versus Prednisone in Heart Failure Patients, Hospitalized With Exacerbation of Chronic Obstructive Pulmonary Disease.
Status: RECRUITING
Conditions: Heart Failure|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Dexamethasone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Continuous Flash Visual Evoked Potentials Monitoring During Endoscopic Skull Base Surgery
Status: UNKNOWN
Conditions: Chiasmal; Lesion|Prechiasmal; Lesion
Interventions: OTHER: intraoperative FVEPs monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Restoration of Hypoglycemia Awareness With Metoclopramide
Status: RECRUITING
Conditions: Hypoglycemia Unawareness
Interventions: DRUG: Metoclopramide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of Intracardiac Ultrasound With the NUVISION NAV Ultrasound Catheter
Status: COMPLETED
Conditions: Scar-related Atrial Tachycardia|Persistent Atrial Fibrillation|Paroxysmal Atrial Fibrillation|Ventricular Tachycardia|Premature Ventricular Complex
Interventions: DEVICE: NUVISION NAV Ultrasound Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing of GVHD With Post-transplantation Cyclophosphamide, Abatacept, Vedolizumab and Baricitinib at Children and Young Adults With Hemoblastosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Biphenotypic Acute Leukemia|Malignant Lymphoma|Myelodysplastic Syndromes
Interventions: DRUG: Baricitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melphalan, Prednisone, Thalidomide And Bortezomib In Advanced And Refractory Multiple Myeloma Patients
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: THALIDOMIDE|DRUG: BORTEZOMIB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Intensity Interval Training, Creatine Intake and Anaerobic Power
Status: COMPLETED
Conditions: Creatine|High Intensity Interval Training
Interventions: DIETARY_SUPPLEMENT: Creatine|OTHER: HIIT training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neck Dissection Via a Robot-assisted Transaxillary Approach in Patients With Squamous Cell Carcinoma of the Epi-larynx
Status: COMPLETED
Conditions: Carcinoma, Squamous Cell
Interventions: PROCEDURE: Neck Dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Marine OXYgen Carrier: HEMO2Life® for hypOthermic Kidney Graft Preservation, Before Transplantation (OXYOP)
Status: COMPLETED
Conditions: End Stage Renal Diseases
Interventions: PROCEDURE: HEMO2Life® use in organ preservation solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dexmedetomidine and Subarachnoid Haemorrhage
Status: COMPLETED
Conditions: Subarachnoid Hemorrhage|Aneurysm
Interventions: DRUG: Dexmedetomidine infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Using Tumour DNA and Proteins to Better Understand How Pancreatic Cancer Responds to Treatment
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma|Resectable Pancreatic Ductal Adenocarcinoma|Borderline Resectable Pancreatic Ductal Adenocarcinoma|Locally Advanced Pancreatic Ductal Adenocarcinoma
Interventions: GENETIC: Genetic testing|PROCEDURE: Optional biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Acolbifene Versus Low Dose Tamoxifen for the Prevention of Breast Cancer in Premenopausal Women at High Risk for Development of Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Atypical Hyperplasia|Breast Carcinoma|Breast Ductal Carcinoma In Situ|Breast Lobular Carcinoma In Situ
Interventions: DRUG: Acolbifene Hydrochloride|PROCEDURE: Biospecimen Collection|PROCEDURE: Mammography|PROCEDURE: Random Periareolar Fine-Needle Aspiration|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: RCT Foley Catheter Study for Elective TJA
Status: COMPLETED
Conditions: Postoperative Urinary Retention|Total Hip Arthroplasty|Total Knee Arthroplasty
Interventions: DEVICE: Indwelling foley catheter|OTHER: No foley catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of the Regulatory Polypeptides in Patients With Peripheral Atherosclerosis.
Status: RECRUITING
Conditions: Peripheral Arterial Occlusive Disease
Interventions: DRUG: Polypeptides|DEVICE: Femoral-popliteal bypass grafting with a synthetic graft above the knee|OTHER: Routine conservative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Masticatory Muscles Training Exercises on the Masticatory Performance and Rehabilitation of Stroke Patients
Status: UNKNOWN
Conditions: Mastication
Interventions: DEVICE: Masticatory muscle training exerciser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Immunogenicity and Safety of a Quadrivalent Meningococcal Conjugate Vaccine in Infants and Toddlers When Administered Concomitantly With Routine Pediatric Vaccines in the United Kingdom
Status: COMPLETED
Conditions: Healthy Volunteers (Meningococcal Infection)
Interventions: BIOLOGICAL: Meningococcal polysaccharide (serogroups A,C,Y and W) tetanus toxoid Conjugate vaccine|BIOLOGICAL: Meningococcal group B vaccine|BIOLOGICAL: Diphtheria, tetanus, pertussis (acellular component), hepatitis B, poliomyelitis (inactivated) vaccine|BIOLOGICAL: Human rotavirus RIX4414 strain vaccine|BIOLOGICAL: Pneumococcal 13-valent polysaccharide conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Healthy Volunteer Study to Investigate the Blood Concentrations, the Effect on Blood Clotting and the Safety of Multiple Doses of DPOC-4088 Tablets in Different Doses.
Status: TERMINATED
Conditions: Deep Vein Thrombosis Leg|Stroke (in Patients With Atrial Fibrillation)
Interventions: DRUG: DPOC-4088|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Correlation Between Cycle Threshold (Ct) Values in COVID-19, Health Status and Laboratory Biomarkers in the Population of Medellin- Colombia Evaluated in a Specialized Laboratory.
Status: UNKNOWN
Conditions: Covid19
Interventions: DIAGNOSTIC_TEST: Levels of SARS-COV-2 antibodies|DIAGNOSTIC_TEST: rRT-PCR SARS-Cov-2|DIAGNOSTIC_TEST: Hematological and immunological biomarkers|DIAGNOSTIC_TEST: Mitochondrial DNA|DIAGNOSTIC_TEST: SARS-CoV-2 Viral Culturing|DIAGNOSTIC_TEST: Sequencing COVID-19
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Adherence of 2 Strengths of Newly Manufactured Samples and Aged Samples of a New Formulation (JNJ-35685-AAA-G016 and JNJ-35685-AAA-G021) of Fentanyl Transdermal System Compared With Duragesic Fentanyl Transdermal Patch in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Duragesic (Fentanyl Transdermal System [TDS] Small Patches)|DRUG: New JNJ-35685-AAA-G016 (Fentanyl TDS -Small Patches)|DRUG: Aged JNJ-35685-AAA-G016 (Fentanyl TDS Small Patches)|DRUG: Duragesic (Fentanyl TDS Large Patches)|DRUG: New JNJ-35685-AAA-G021 (Fentanyl TDS Large Patches)|DRUG: Aged JNJ-35685-AAA-G021 (Fentanyl TDS Large Patches)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: |Primary Purpose: OTHER