pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Adjuvant Chemotherapy Combined With Camrelizumab for ⅡA -ⅢA NSCLC Patients
Status: RECRUITING
Conditions: Immunotherapy|Chemotherapy
Interventions: DRUG: Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of SQZ-AAC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors
Status: TERMINATED
Conditions: Adult Solid Tumor
Interventions: BIOLOGICAL: SQZ-AAC-HPV|DRUG: Ipilimumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Biological Activity of SAR100842 in Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis
Interventions: DRUG: SAR100842|DRUG: Placebo (for SAR100842)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Polyheal-1 in Treatment of Recalcitrant Wounds
Status: UNKNOWN
Conditions: Wounds and Injuries
Interventions: DEVICE: Suspension of polystyrene beads (POLYHEAL 1)|DEVICE: Saline (0.9% NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Racecadotril in Acute Watery Diarrhea in Children
Status: COMPLETED
Conditions: Acute Diarrhea|Acute Gastroenteritis
Interventions: DRUG: Racecadotril|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Navicam as a Triage Tool in the Management of Patients With Acute Upper Gastrointestinal Bleeding
Status: COMPLETED
Conditions: GastroIntestinal Bleeding
Interventions: DEVICE: NaviCam (ANKON)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tetrahydrobiopterin (BH4)|DIETARY_SUPPLEMENT: Antioxidant Cocktail
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Improving Surgical Outcomes With Early PT After ACDF
Status: RECRUITING
Conditions: Cervical Spine Degeneration|ACDF Surgery
Interventions: OTHER: Early PT|OTHER: Delayed PT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparator Study of LT-NS001 in Healthy Subjects With Endoscopic Evaluation
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LT-NS001|DRUG: Naprosyn®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Virtual Reality During Conization of Cervix Uterus Under Local Anesthesia
Status: UNKNOWN
Conditions: Dysplasia, Cervix
Interventions: DEVICE: SootheVR: AppliedVR, Los Angeles, California a head-mounted display
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Oral Stimulation and Supplemental Nursing System
Status: COMPLETED
Conditions: Breastfeeding
Interventions: DEVICE: Oral motor stimulation (OMS) and The supplemental nursing system (SNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing Hemodynamic Changes for Intubation With Shikani Intubating Stylet and Macintosh Laryngoscope
Status: COMPLETED
Conditions: Anesthesia
Interventions: DEVICE: Endotracheal Intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of CNTO 136 (Sirukumab), Administered Subcutaneously, in Patients With Active Rheumatoid Arthritis Despite Disease-Modifying Antirheumatic Drug (DMARD) Therapy (SIRROUND-D)
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Placebo|DRUG: Placebo|DRUG: Sirukumab|DRUG: Sirukumab|DRUG: Sirukumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparation of Treatment Strategies for OVF: Teriparatide Injection and PVP
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoporosis, Postmenopausal|Vertebral Fracture|Quality of Life
Interventions: DRUG: Teriparatide|PROCEDURE: PVP|DRUG: Alendronate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Role of Serotonin in Hot Flashes After Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DIETARY_SUPPLEMENT: Acute tryptophan depletion|DIETARY_SUPPLEMENT: Half-strength tryptophan depletion (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Umbilical Cord Milking in Non-Vigorous Infants Developmental Followup (MINVIFU)
Status: COMPLETED
Conditions: Neurodevelopmental Abnormality
Interventions: PROCEDURE: Umbilical Cord Milking|PROCEDURE: Early Cord Clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of LY900014 Compared to Insulin Lispro (Humalog) in Adults With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: LY900014|DRUG: Insulin Lispro|DRUG: Insulin Glargine|DRUG: Insulin Degludec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: V221 Concomitant Use Study With Pneumococcal Conjugate Vaccine (V221-019)
Status: COMPLETED
Conditions: Measles|Mumps|Rubella|Varicella
Interventions: BIOLOGICAL: Comparator: ProQuad™ (V221)|BIOLOGICAL: Comparator: PREVNAR™ (pneumococcal 7-valent conjugate vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparing Analgesic Effects of Caudal and Erector Spinae Plane Blocks in Pediatrics Undergoing Upper Abdominal Surgery
Status: COMPLETED
Conditions: Anesthesia, Local
Interventions: DRUG: Bupivacaine 0.7 ml/kg|DRUG: Bupivacaine 0.5 ml/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Hypertonic Saline for MAC
Status: RECRUITING
Conditions: Nontuberculous Mycobacterial Lung Disease|Nontuberculous Mycobacterium Infection
Interventions: DRUG: Hypertonic saline|DRUG: Azithromycin|DRUG: Ethambutol|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cotrimoxazole Prophylaxis in Transurethral Resection or Greenlight Laser Vaporisation of the Prostate
Status: COMPLETED
Conditions: Antimicrobial Prophylaxis in Prostate Surgery
Interventions: DRUG: oral applications of TMP/SMX 800/160 mg (Nopil forte® tablets)|DRUG: oral applications of Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of the Knee Joint
Status: RECRUITING
Conditions: Osteoarthritis|Osteo Arthritis Knee
Interventions: DRUG: OA-SYS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AZD1775 in Advanced Acute Myeloid Leukemia, Myelodysplastic Syndrome and Myelofibrosis
Status: TERMINATED
Conditions: Myelofibroses|Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: Combination AZD1775 with AraC|DRUG: AZD1775 only
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Efficacy and Safety of LB54640 in Patients With Hypothalamic Obesity
Status: RECRUITING
Conditions: Hypothalamic Obesity
Interventions: DRUG: LB54640|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effects of Sorafenib if Combined With Chemotherapy (FOLFOX6 or FOLFIRI) in the Second-Line Treatment of Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Neoplasms
Interventions: DRUG: Sorafenib|DRUG: Placebo|DRUG: Oxaliplatin or Irinotecan|DRUG: Leucovorin|DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation (tDCS) Therapy in Major Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: Active - HD tDCS|DEVICE: Sham - HD tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of ASP0456 in Patients With Constipation Predominant Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Constipation-predominant Irritable Bowel Syndrome (IBS-C)
Interventions: DRUG: linaclotide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Multi-Purpose Solution-Based Corneal Staining and Ocular Comfort
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Soft contact lens|DRUG: Marketed soft lens multipurpose disinfection regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of TV-1106 in Growth Hormone-Deficient Adults
Status: TERMINATED
Conditions: Growth Hormone Deficiency
Interventions: DRUG: TV-1106|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pharmacokinetic Drug Interaction Study of the Hedgehog Pathway Inhibitor GDC-0449 in Combination With Rosiglitazone or Combined Oral Contraceptive in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists
Status: COMPLETED
Conditions: Solid Cancers
Interventions: DRUG: Vismodegib|DRUG: Rosiglitazone|DRUG: Norethindrone/ethinyl estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery
Status: RECRUITING
Conditions: Pain, Postoperative|Narcotic Use
Interventions: DRUG: Melatonin 10 MG|DRUG: Lactose pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: The ED-AWARENESS-2 Trial
Status: RECRUITING
Conditions: Awareness|Mechanical Ventilation|Intubation Complication|PTSD
Interventions: OTHER: Standard neuromuscular blocker practices|BEHAVIORAL: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial Comparing Combined Spinal- Epidural Dosing Strategies for External Cephalic Version
Status: COMPLETED
Conditions: Pregnancy|Pain
Interventions: DRUG: Group 2.5|DRUG: Group 5|DRUG: Group 7.5|DRUG: Group 10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Ceftazidime-Avibactam for the Treatment of Infections Due to Ceftazidime Resistant Pathogens
Status: COMPLETED
Conditions: Complicated Urinary Tract Infection|Complicated Intra-abdominal Infection
Interventions: DRUG: Ceftazidime - Avibactam ( CAZ-AVI)|DRUG: Best Available Therapy|DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CCTG 595: Text Messaging Intervention to Improve Adherence to PrEP in High-risk MSM
Status: COMPLETED
Conditions: Patient Adherence|HIV Seronegativity
Interventions: DEVICE: SoC + iTab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regorafenib and Nivolumab in Mismatch Repair (MMR) Refractory Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Metastatic Colorectal Cancer|Colon Cancer
Interventions: DRUG: Regorafenib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cvac as Maintenance Treatment in Patients With Epithelial Ovarian Cancer in Complete Remission Following First-line Chemotherapy or Second-line Treatment
Status: TERMINATED
Conditions: Epithelial Ovarian Cancer
Interventions: BIOLOGICAL: Cvac|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Peppermint Oil in Mild-moderate Hypertension.
Status: RECRUITING
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Peppermint oil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Do Video Materials Help Parents to Support Infant Development?
Status: UNKNOWN
Conditions: Language Development
Interventions: BEHAVIORAL: BBC Education Tiny Happy People videos|BEHAVIORAL: Physical health control intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of a Hybrid Cardiac Rehabilitation Program
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases
Interventions: OTHER: Center-based Cardiac Rehabilitation Intervention|OTHER: Hybrid Cardiac Rehabilitation Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Communication After Placement of Orthodontic Fixed Appliances on Pain, Anxiety and Oral Health Quality of Life Among Malaysian Population
Status: UNKNOWN
Conditions: Orthodontic Pain
Interventions: BEHAVIORAL: Whatsapp|BEHAVIORAL: Call
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Tislelizumab (BGB-A317) Versus Chemotherapy as Second Line Treatment in Participants With Advanced Esophageal Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Esophageal Squamous Cell Carcinoma (ESCC)
Interventions: DRUG: Tislelizumab|DRUG: Paclitaxel|DRUG: Docetaxel|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of Two PRF Formulations on Quality of Life and Healing of Apicomarginal Defects
Status: UNKNOWN
Conditions: Apico Marginal Defects
Interventions: PROCEDURE: Periapical surgery with use of prf-high clot and membrane|PROCEDURE: Periapical surgery with use of prf-medium clot and membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Bupivacaine and Levobupivacaine on Cerebral Oxygenation During Intrathecal Anesthesia in Elderly Patients
Status: COMPLETED
Conditions: Complication of Anesthesia
Interventions: DRUG: fentanyl 15 microg|DRUG: Bupivacaine 7 mg|DRUG: Bupivacaine 9 mg|DRUG: Levobupivacaine 7 mg|DRUG: Levobupivacaine 9 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Adenosine on Cranial Hemodynamic, Headache and Migraine Induction Properties.
Status: COMPLETED
Conditions: Headache, Migraine
Interventions: DRUG: Adenosine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate Safety & Immunogenicity of SARS-CoV-2 DNA Vaccine Delivered Intramuscularly Followed by Electroporation for COVID-19
Status: UNKNOWN
Conditions: Covid19
Interventions: BIOLOGICAL: SARS-CoV-2 DNA Vaccine|BIOLOGICAL: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I Functional Magnetic Resonance Imaging (fMRI) Pharmacodynamic Studies of Compounds for Opioid Use Disorder and Cocaine Use Disorder
Status: TERMINATED
Conditions: Cocaine-Related Disorders|Opioid-Related Disorders
Interventions: DRUG: Group A Lorcaserin (10mg)|DRUG: Group A2 Lorcaserin (20 mg)|OTHER: Group B Parallel Placebo|OTHER: Group B2 Parallel Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Pharmacokinetics of a Modified-release Tacrolimus Based Immunosuppression Regimen in Stable Liver Transplant Patients
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: DRUG: tacrolimus modified release (MR)|DRUG: tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Collagen IV and XIX in Bronchoalveolar Lavage, Pulmonary Aspiration and Bronchial Biopsies
Status: COMPLETED
Conditions: Chronic Obstructive Bronchopneumopathy|Infectious Pneumonia|Pneumonitis|Lung Cancer
Interventions: BIOLOGICAL: biological fluids (serum, bronchoalveolar lavage and pulmonary aspiration) and bronchial biopsies collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized, Double-Blind, Placebo-Controlled, Sequential Parallel Study of CERC-301 in the Adjunctive Treatment of Subjects With Severe Depression and Recent Active Suicidal Ideation Despite Antidepressant Treatment
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: CERC-301|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study to Evaluate Efficacy and Safety When Metformin Hydrochloride 500 mg Once Daily is Added on to SYR-322 25 mg in Type 2 Diabetic Patients With Inadequate Glycemic Control Despite Treatment With SYR-322 25 mg in Addition to Diet and Exercise Therapy
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Alogliptin|DRUG: Metformin hydrochloride|DRUG: Metformin hydrochloride Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CAPPA-2: Cisplatin Added to Gemcitabine in Poor Performance Advanced NSCLC Patients
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: gemcitabine|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study to Evaluate Safety and Efficacy of Cretostimogene Grenadenorepvec in NMIBC
Status: NOT_YET_RECRUITING
Conditions: High-Risk Non-Muscle-Invasive Bladder Cancer
Interventions: DRUG: Cretostimogene Grenadenorepvec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In Vitro Pharmacodynamic Effects of Cangrelor in Ticagrelor Treated Patients
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Ticagrelor 180mg|DRUG: Ticagrelor 90mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Correlation Between Estimated Glomerular Filtration Rate(eGFR) and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG)
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: RADIATION: 18FDG-PET
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Double-blind, Placebo-control, Study to Evaluate the Safety and Pharmacokinetics of CT-044 HCl, in Healthy Volunteers
Status: UNKNOWN
Conditions: Acute Pain|Pain, Acute|Surgery|Neuropathy
Interventions: DRUG: CT-044 HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Mineralocorticoid Receptor Antagonists (MRA) in Heart Failure (HF) and Loop Diuretic Resistance
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Spironolactone 100mg|DRUG: Spironolactone 25mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Ologen® Collagen Matrix in Preventing Intraocular Pressure (IOP) Spikes After Ahmed Glaucoma Valve Surgery (AGV-FP7)
Status: TERMINATED
Conditions: Glaucoma
Interventions: PROCEDURE: Ologen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis
Status: COMPLETED
Conditions: HTLV-1
Interventions: DRUG: Hu MiK-Beta-1
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of Efficacy and Safety of Rosnilimab in Subjects With Moderate to Severe Ulcerative Colitis (ROSETTA)
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: Rosnilimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ONC-201 Maintenance Therapy in Acute Myeloid Leukemia and Myelodysplastic Syndrome After Stem Cell Transplant
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: ONC-201
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of AD128 to Treat Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DRUG: AD128|DRUG: Mannitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single-arm, Open-label Clinical Study of SZ011 in the Treatment of Ovarian Epithelial Carcinoma
Status: RECRUITING
Conditions: Ovarian Epithelial Carcinoma
Interventions: DRUG: SZ011 CAR-NK
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Pancreatic Enzymes in Patients Pancreatic Insufficient: Comparison of Two Drugs
Status: WITHDRAWN
Conditions: Chronic Renal Failure
Interventions: BIOLOGICAL: Pancreatic enzimes|DEVICE: Creon ®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of BMS-986393 in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: BMS-986393|DRUG: Alnuctamab|DRUG: Mezigdomide|DRUG: Iberdomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Amphotericin B in 30% Dimethylsulphoxide in Treating of Non-dermatophytes Onychomycosis
Status: COMPLETED
Conditions: Fungal Infection|Onychomycosis|Fungus, Nail
Interventions: DRUG: amphotericin B in 30% DMSO|DRUG: 30% DMSO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of Andrographolide Sulfonate in Patients With Acute Tonsillitis
Status: UNKNOWN
Conditions: Acute Tonsillitis
Interventions: DRUG: Andrographolide sulfonate|DRUG: Andrographolide sulfonate simulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Efficacy of Allogeneic Umbilical Cord Mesenchymal Stem Cells in Patients With Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: BIOLOGICAL: Allogeneic umbilical cord mesenchymal stem cells|BIOLOGICAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Blood Glucose Response to Highly Viscous Polysaccharide Enriched Biscuits in Healthy and Diabetic Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Highly viscous polysaccharide enriched biscuits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate Efficacy, Safety, and Tolerability of Remibrutinib Compared With Placebo in Adults With CINDU Inadequately Controlled by H1-antihistamines
Status: RECRUITING
Conditions: Chronic Inducible Urticaria
Interventions: DRUG: Remibrutinib|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Prebiotic and PUFA on the Gut Microbiota and Metabolic Risk Markers
Status: COMPLETED
Conditions: Overweight
Interventions: DIETARY_SUPPLEMENT: Wheat bran extract|DIETARY_SUPPLEMENT: Fish oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparative Study on Pharmacokinetics of Two Formulations of Jaktinib in Healthy Adults Under Fasting Conditions
Status: COMPLETED
Conditions: Myelofibrosis
Interventions: DRUG: Jaktinib Hydrochloride Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotics in Patients With Moderate-to-severe Distention/ Bloating From Systemic Sclerosis
Status: WITHDRAWN
Conditions: Scleroderma
Interventions: DRUG: Lactobacillus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Controlled Trial Comparing Nomogram-based Versus Standard Allocation of Acute Normovolemic Hemodilution (ANH) During Hepatic Resection
Status: COMPLETED
Conditions: Liver Cancer
Interventions: PROCEDURE: nomogram-based selection for acute normovolemic hemodilution|PROCEDURE: standard selection for ANH based on a planned resection of 3 or more segments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Letermovir Prophylaxis for Cytomegalovirus (CMV) in Patients With Graft-versus-host Disease
Status: NOT_YET_RECRUITING
Conditions: Graft-versus-host-disease|CMV
Interventions: DRUG: Letermovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety Study of Sublingual Immunotherapy Tablets of House Dust Mite Allergen Extracts
Status: COMPLETED
Conditions: Asthma|House Dust Mite Allergy
Interventions: BIOLOGICAL: SLIT tablets of house dust mite allergen extracts|BIOLOGICAL: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Valsartan and Amlodipine Combined and Alone in Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: valsartan+amlodipine combination|DRUG: valsartan|DRUG: amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Proof-of-Concept Trial of Palonosetron and Olanzapine Without Dexamethasone for the Prevention of CIN
Status: UNKNOWN
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: DRUG: Olanzapine|DRUG: Palonosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: BELgian CT-perFUSion Study to Select Acute Stroke Patients for Thrombectomy
Status: WITHDRAWN
Conditions: Stroke|Stroke, Acute|Stroke, Ischemic
Interventions: DEVICE: perfusion CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cetuximab in Third Line for Mutant APC, TP53 and RAS Patients With Refractory Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Randomized, Open Label Trial of Two Doses of Oral Betaine
Status: RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease|Non Insulin Dependent Diabetes|ALT
Interventions: DIETARY_SUPPLEMENT: Betaine (trimethyglycine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Technology to Assess Treatment for Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Xenon129 MRI imaging|DRUG: Gadolinium MRI|DRUG: Advair (250mcg/50mcg) one puff twice a day
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase III Study of Sorafenib in Patients With Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Sorafenib (Nexavar, BAY43-9006)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Combinations in Antiretroviral Post-Exposure Prophylaxis for HIV-1: Tenofovir/Emtricitabine (Truvada ®) + Lopinavir/Ritonavir (Kaletra ®) vs Tenofovir/Emtricitabine/Cobicistat/Elvitegravir (Stribild ®). Prospective, Randomized, Open.
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Tenofovir + emtricitabine (Truvada),+lopinavir/ritonavir (Kaletra)|DRUG: elvitegravir/cobicistat/emtricitabine/Tenofovir-Disoproxil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Imaging Characteristics of Florbetapir 18F in Patients With Frontotemporal Dementia, Alzheimer's Disease and Normal Controls.
Status: COMPLETED
Conditions: Alzheimer's Disease|Frontotemporal Dementia
Interventions: DRUG: florbetapir 18F|DRUG: 18F-FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Bevacizumab in the Treatment of Malignant Pleural Effusions of Non-squamous Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Malignant Pleural Effusion
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digital Cognitive Behavior Therapy for Insomnia Compared With Digital Patient Education About Insomnia in Individuals Referred to Public Mental Health Services in Norway
Status: ACTIVE_NOT_RECRUITING
Conditions: Mental Disorder|Insomnia
Interventions: BEHAVIORAL: digital cognitive behavioral therapy (dCBT-I)|BEHAVIORAL: Digital patient education about insomnia (PE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and PK of HM10460A (HNK460) in Healthy Adult Japanese and Caucasian Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HM10460A or placebo or Neulasta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Food-Effect of KQ-791
Status: COMPLETED
Conditions: Healthy Volunteers|Insulin Resistance
Interventions: DRUG: KQ-791|DRUG: KQ-791 (after meal)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Compare the Efficacy and Safety of a Combination of Ketoconazole and Clindamycin Compared to Tetracycline/Amphotericin B Combination Cream for the Treatment of Bacterial Vaginosis and Vaginal Candidiasis (P08077)
Status: COMPLETED
Conditions: Vaginosis, Bacterial|Candidiasis, Vulvovaginal
Interventions: DRUG: 100 mg clindamycin /800 mg ketoconazole vaginal ovule|DRUG: 100 mg tetracycline hydrochloride /50 mg amphotericin B cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Doses of Dexmedetomidine on Postoperative Cognitive Dysfunction in Elderly Hypertensive Patients
Status: UNKNOWN
Conditions: Postoperative Cognitive Dysfunction
Interventions: DRUG: dexmedetomidine|DRUG: dexmedetomidine|DRUG: normal saline|DRUG: midazolam,fentanyl,etomidate,Cisatracurium besylate|DRUG: cisatracurium besylate,propofol,remifentanil,sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Differences in Endothelial Function Amongst Sitagliptin and Liraglutide Users
Status: COMPLETED
Conditions: DIABETES Mellitus Type 2 Not Well Controlled
Interventions: DRUG: Liraglutide|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Seroquel in the Treatment of Dysphoric Hypomania in Bipolar II
Status: COMPLETED
Conditions: Bipolar II Disorder
Interventions: DRUG: Quetiapine/Seroquel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Botulinum Toxin A for Treatment of Overactive Bladder in Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson's Disease|Overactive Bladder|Onabotulinumtoxin A
Interventions: DRUG: oral anti-Parkinson drugs and injection of botulinum toxin|DRUG: oral anti-Parkinson's drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colchicine to Reduce Cardiac Injury in COVID-19 (COLHEART-19)
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Colchicine Tablets|OTHER: Current care per UCLA treating physicians
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Study of Comparing Follitrope Versus Gonal-f in Chinese Infertility Women.
Status: COMPLETED
Conditions: Infertility, Female
Interventions: BIOLOGICAL: Follitrope PFS|BIOLOGICAL: Gonal-f pen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study Evaluating the Adrenal Suppression Potential of Product 0405 in Pediatric Subjects With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Product 0405
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pursed Lip Breathing With Arm Ergometry After Chin Supported Position in COPD Patients.
Status: COMPLETED
Conditions: COPD
Interventions: OTHER: Chin supported Arm ergometry with pursed lip breathing|OTHER: Arm ergometry with pursed lip breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Nivolumab Plus Ipilimumab for Newly Diagnosed Malignant Peripheral Nerve Sheath Tumor
Status: RECRUITING
Conditions: Nerve Sheath Tumors
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ziprasidone for the Treatment of Generalized Anxiety in Patients With Bipolar Disorder
Status: TERMINATED
Conditions: Generalized Anxiety Disorder|Bipolar Disorder
Interventions: DRUG: Ziprasidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Label Study in Patients With Advanced NSCLC With ABI-007(Abraxane) in Combination With Carboplatin
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: ABI-007 (Abraxane) and Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-delivered Cognitive Behavioural Therapy for Persons With Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries|Anxiety|Depression
Interventions: BEHAVIORAL: Guided ICBT|OTHER: SCI rehabilitation mental health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Brentuximab Vedotin in Subjects With Relapsed/Refractory T-cell Lymphoma
Status: RECRUITING
Conditions: T-Cell Lymphoma
Interventions: DRUG: Brentuximab vedotin|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Duration of Long Acting Muscarinic Antagonist (LAMA) Bronchoprotection Against Methacholine Challenge
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Tiotropium|DRUG: glycopyrronium|DEVICE: Respimat|DEVICE: Breezehaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Simple Needle Guide Device for Ultrasound-guided Internal Jugular Vein Catheterization in Cardiac Surgical Patients
Status: WITHDRAWN
Conditions: Cardiac Surgery
Interventions: DEVICE: Sono with Device|DEVICE: sono only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Validation and Usability Study of Intermittent Electrical Simulation in Management of Pressure Injuries Stages 1 and 2
Status: NOT_YET_RECRUITING
Conditions: Pressure Injury
Interventions: DEVICE: Prelivia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study Evaluating The Effects Of Oprelvekin On Cardiac Repolarization In Subjects With Chemotherapy Induced Thrombocytopenia
Status: TERMINATED
Conditions: Severe Thrombocytopenia
Interventions: DRUG: oprelvekin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential Treatment With GEMBRAX and Then FOLFIRINOX Followed by Stereotactic MRI-guided Radiotherapy in Patients With Locally Advanced Pancreatic Cancer
Status: RECRUITING
Conditions: Locally Advanced Pancreatic Adenocarcinoma
Interventions: COMBINATION_PRODUCT: Gabrinox|RADIATION: MRI-GUIDED STEREOTACTIC RADIOTHERAPY
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characteristics of T Cells From Alopecia Areata Scalp Skin Before and After Treatment With Aldara 5%
Status: COMPLETED
Conditions: Alopecia Areata
Interventions: DRUG: Aldara Cream 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Subcutaneous Injection of Autologous Adipose Tissue-derived Stromal Vascular Fraction Into the Fingers of Patients With Systemic Sclerosis
Status: TERMINATED
Conditions: Scleroderma, Systemic
Interventions: DRUG: Stromal Vascular fraction|DRUG: Ringer lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gefitinib in Treating Patients With Stage IB, II, or IIIA Non-small Cell Lung Cancer That Was Completely Removed by Surgery
Status: COMPLETED
Conditions: Adenocarcinoma of the Lung|Adenosquamous Cell Lung Cancer|Bronchoalveolar Cell Lung Cancer|Large Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IB Non-small Cell Lung Cancer|Stage IIA Non-small Cell Lung Cancer|Stage IIB Non-small Cell Lung Cancer|Stage IIIA Non-small Cell Lung Cancer
Interventions: DRUG: gefitinib|OTHER: placebo|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spina Block or Parasternal Block Plus Chest Tube Wound Infiltration for Cardiac Surgeries
Status: NOT_YET_RECRUITING
Conditions: Postoperative Pain|Postoperative Atelectasis|Analgesia
Interventions: PROCEDURE: Comparison of erector spina plane block, parasternal block plus local infiltration to the tube sides for postoperative analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Doulas as Environmental Educators and Partners Study
Status: RECRUITING
Conditions: Health Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: Online educational phthalate course|BEHAVIORAL: Control environmental education|BEHAVIORAL: Phthalate conversation|BEHAVIORAL: Environmental exposures conversation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Thymoglobulin to Prevent Acute Graft vs. Host Disease (GvHD) in Patients With Acute Lymphocytic Leukemia (ALL) or Acute Myelogenous Leukemia (AML) Receiving a Stem Cell Transplant
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia (AML)|Acute Lymphocytic Leukemia (ALL)|Graft vs. Host Disease (GvHD)
Interventions: BIOLOGICAL: Thymoglobulin [Anti-Thymocyte Globulin (Rabbit)]|BIOLOGICAL: Thymoglobulin [Anti-Thymocyte Globulin (Rabbit)]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Treatment of Mania Symptoms With Drug Therapy
Status: COMPLETED
Conditions: Bipolar Disorder|Schizophrenia
Interventions: DRUG: Divalproex-extended release (DVP-ER)|DRUG: Lithium|DRUG: Quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Senobi and Jacobsons Exercises in COPD
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Senobi exercises|OTHER: Jacobsons Muscular relaxation exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Improvement in Sleep Symptomatology and Neurocognitive Function Using Photobiomodulation in Post-Concussion Patients
Status: RECRUITING
Conditions: Post-Concussion Syndrome|Sleep Disorder
Interventions: DEVICE: Photobiomodulation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT