pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase II Study Evaluating Exemestane Alone Or In Combination With Pazopanib In Postmenopausal Women With Hormone Receptor Positive Breast Cancer
Status: WITHDRAWN
Conditions: Hormone-receptor Positive Breast Cancer
Interventions: DRUG: exemestane and pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Adjusted Fibrinogen Replacement Strategy
Status: COMPLETED
Conditions: Bleeding Disorder|Hypofibrinogenemia; Acquired
Interventions: BIOLOGICAL: BT524|BIOLOGICAL: FFP/Cryo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ATS 3f Enable(tm) Aortic Bioprosthesis, Model 6000
Status: COMPLETED
Conditions: Heart Valve Diseases
Interventions: DEVICE: ATS 3f Enable Aortic Bioprosthesis Model 6000
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decitabine and Midostaurin in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukemia (AML) With Multilineage Dysplasia Following Myelodysplastic Syndrome, in Adults|AML (Adult) With 11q23 (MLL) Abnormalities|AML (Adult) With Del (5q)|AML (Adult) With Inv (16) (p13; q22)|AML (Adult) With t (16;16) (p13; q22)|AML (Adult) With t (8; 21) (q22; q22)|Secondary AML (Adult)|Untreated AML (Adult)
Interventions: DRUG: Decitabine|DRUG: Midostaurin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of SMS and Smartphone Interventions for OneTouch Reveal® Experiences
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: OneTouch Reveal® Mobile APP|DEVICE: OneTouch Verio® Flex BGMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Trial to Assess the Efficacy of Reducing the Aligners' Wear Protocol on the Predictability of Orthodontic Tooth Movement
Status: RECRUITING
Conditions: Orthodontic Tooth Movement
Interventions: DEVICE: Invisalign 7-day wear protocol|DEVICE: Invisalign 3-day wear protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Donafenib Combined With Tislelizumab in the Adjuvant Treatment of Primary HCC With High Risk of Recurrence
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Donafenib + Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 2nd Generation E1/E2B/E3-Deleted Adenoviral COVID-19 Vaccine: The TCELL VACCINE TRIAL
Status: TERMINATED
Conditions: COVID-19
Interventions: BIOLOGICAL: hAd5-S-Fusion+N-ETSD|BIOLOGICAL: Placebo (0.9% (w/v) saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a Novel Interposition Supraciliary Implant in Patients With Open Angle Glaucoma (SAFARI 2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Glaucoma, Open-Angle
Interventions: DEVICE: Interposition supraciliary implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IIT Assessing OC-01Nasal Spray on Symptoms of DED Following CXL
Status: UNKNOWN
Conditions: Dry Eye Disease
Interventions: DRUG: OC-01 (varenicline 1.2mg/ml) nasal spray vs Placebo|OTHER: Placebo (vehicle) nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Serum Concentration of Tranexamic Acid After Topical Administration in Massive Weight Loss Skin Reducing Surgery
Status: COMPLETED
Conditions: Surgical Wound|Bleeding
Interventions: DRUG: Tranexamic Acid 25 mg/ml for wound surface moistening|DRUG: Tranexamic Acid 5 mg/ml as bolus in wound cavity|DRUG: Tranexamic Acid Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Neoadjuvant Chemotherapeutic Treatment (XELOX) Followed by Chemoradiotherapy (XELOX/RT) and Surgery Versus Chemoradiotherapy Followed by Surgery and Chemotherapy in Patients With High Risk Rectal Cancer
Status: COMPLETED
Conditions: Rectal Neoplasms
Interventions: DRUG: Oxaliplatin, capecitabine|DRUG: Oxaliplatin, capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Controlled Study of an Herbal Topical Patch in Treating Osteoarthritis (OA) of the Knee
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Herbal Patch|OTHER: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation to Assess the Safety and Feasibility of the Crestal, Minimal-invasive Sinus Floor Augmentation With the Pressure Chamber Drill (DKK) and the Sinus Vibration Pump (SVP)
Status: UNKNOWN
Conditions: Insufficient Bone Mass in the Maxilla for Dental Implants
Interventions: DEVICE: minimal-invasive sinus floor augmentation with the DKK and SVP (JEDER Syst.)|DEVICE: minimal invasive crestal sinus lift with the JEDER Systh.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PEDI-REAVASC Resonance Imaging of Infants With Hypoxic Ischemic Encephalopathy After Hypothermia Treatment.
Status: ACTIVE_NOT_RECRUITING
Conditions: Encephalopathy, Hypoxic-Ischemic
Interventions: DIAGNOSTIC_TEST: MRI-scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Transcatheter Aortic Valve Replacement With Extracorporeal Life System Support
Status: UNKNOWN
Conditions: Aortic Stenosis|Aortic Regurgitation|Heart Failure With Reduced Ejection Fraction
Interventions: PROCEDURE: transcatheter aortic valve replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study of SPD489 in Adults With Major Depressive Disorder (MDD) as Augmentation Therapy to an Antidepressant
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Antidepressant + SPD489 (lisdexamfetamine dimesylate)|DRUG: Antidepressant + placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Effect of Transcranial Magnetic Stimulation in Mild to Moderate Alzheimer's Disease
Status: UNKNOWN
Conditions: Mild to Moderate Alzheimer Disease
Interventions: DEVICE: TMS|DEVICE: sham coil stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of GlucoClear CGM System on the Performance of Insulin Therapy in Critically Ill Patients
Status: COMPLETED
Conditions: Metabolic Stress Hyperglycemia
Interventions: DEVICE: Intravascular continuous monitoring|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Systemic or Perineural Dexamethasone on the Duration of Interscalene Nerve Blocks With Ropivacaine
Status: TERMINATED
Conditions: Duration of Interscalene Block
Interventions: OTHER: ropivacaine plus dexamethasone anesthetic|OTHER: ropivacaine plus saline plus dexamethasone anesthetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 3T Perfluorocarbon-Filled Endorectal Magnetic Resonance Spectroscopic Imaging of Prostate
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: PROCEDURE: 3T Magnetic Resonance Spectroscopic Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Diagnosis of Inflammatory Bowel Disease by Examining the Entire Bowel by Pan-intestinal Capsule Endoscopy
Status: UNKNOWN
Conditions: Inflammatory Bowel Diseases|Morbus Crohn
Interventions: DEVICE: Panintestinal video capsule endoscopy|DEVICE: Colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of rTMS in Pathological Gamblers
Status: COMPLETED
Conditions: Pathological Gambler
Interventions: DEVICE: rTMS active then rTMS placebo|DEVICE: rTMS placebo then rTMS active
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A First in Human Single and Multiple Ascending Dose and Open Label Food Effect Study of OR-101 in Healthy Subjects
Status: WITHDRAWN
Conditions: Alopecia Areata
Interventions: DRUG: OR-101 (Single ascending dose)|DRUG: OR-101 (Food effect)|DRUG: OR-101 (Multiple ascending dose)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Minnesota Community-Based Cognitive Training in Early Psychosis
Status: COMPLETED
Conditions: Schizophrenia|Psychosis|Schizoaffective Disorder|Schizophreniform Disorders|Psychosis NOS|Depression Psychotic Feature|Bipolar Disorder With Psychotic Features|Unspecified Psychosis
Interventions: DEVICE: Targeted Cognitive Training|DEVICE: General Cognitive Exercises|OTHER: Coordinated Specialty Care for First Episode Psychosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy for Adolescents With Attention-Deficit / Hyperactivity Disorder
Status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: Cognitive Behavioural & Skills Training|BEHAVIORAL: Supportive Group Therapy|OTHER: Treatment as Usual - community resources|DRUG: Methylphenidate or amphetamine product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 3-D Imaging Assessment of Scar Formation and Would Healing in Fat Grafted vs Non-Fat Grafted Facial Reconstruction Wound Sites
Status: WITHDRAWN
Conditions: Scar Formation|Autologous Fat Grafting
Interventions: PROCEDURE: Autologous Fat Grafting|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of C-CAR066 in Subjects With r/r Diffuse Large B Cell Lymphoma Who Received CD19 CAR-T Therapy
Status: COMPLETED
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: C-CAR066
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Family and Individual Factors in Going Through Adolescence - Perspective of a Healthy Child.
Status: RECRUITING
Conditions: Disability, Intellectual|Disability Psychological|Disability, Developmental|Diabetes|Sibling Relations|Adolescent Development|Adolescent Behavior|Peer Group|Well-Being, Psychological|Family Relations
Interventions: DIAGNOSTIC_TEST: Psychological tests and psychosocial questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study of the Osteo-Fluidic-Sensitive (OFS) in Tension-type Headache.
Status: RECRUITING
Conditions: Tension-Type Headache Episodic
Interventions: OTHER: Osteo fluidic Sensitive méthod|OTHER: Placebo method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study in Healthy Adults Who Sometimes Take Drugs for Pleasure Which Aims to Evaluate Whether GRT0151Y is Likely to be Abused
Status: COMPLETED
Conditions: Pain|Acute Pain
Interventions: DRUG: GRT0151Y 50 mg capsule|DRUG: Hydromorphone IR 4 mg|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The TELENEO Trial: A Multicenter Trial of Telemedicine for Advanced Neonatal Resuscitations in Community Hospitals
Status: RECRUITING
Conditions: Death; Neonatal|Morbidity;Newborn
Interventions: OTHER: Teleneonatology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Escitalopram Treatment of Patients With Agitated Dementia
Status: COMPLETED
Conditions: Alzheimer's Disease|Psychomotor Agitation
Interventions: DRUG: Escitalopram (Lexapro)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TREAT Child Alcohol Use Disorder (C-AUD) in Eastern Uganda
Status: RECRUITING
Conditions: Alcohol Abuse|Alcohol Drinking|Alcoholism|Alcohol Use Disorder|Alcohol Dependence|Child Abuse|Child Malnutrition|Child Neglect|Child Mental Disorder|Child, Only
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser
Status: ACTIVE_NOT_RECRUITING
Conditions: Lentigo
Interventions: DRUG: lidocaine 2.5%/prilocaine 2.5% topical anesthetic|DRUG: lidocaine 7%/tetracaine 7% topical anesthetic|DRUG: placebo vehicle|DEVICE: Q-switched 532nm Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: An Exploratory, Open Label, Single Center Study of [F-18]HX4
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: 20 mCi dose for a 50 kg individual of [F-18]HX4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: The Impact of Caffeine on Brachial Endothelial Function in Healthy Subjects and in Patients With Ischemic Heart Disease
Status: COMPLETED
Conditions: Coronary Disease
Interventions: DRUG: Caffeine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Radiofrequency Ablation of Bilateral Inferior Turbinate Followed by Subcutaneous Immunotherapy Trial
Status: NOT_YET_RECRUITING
Conditions: Allergic Rhinitis Due to House Dust Mite
Interventions: PROCEDURE: Radiofrequency ablation of bilateral inferior turbinate followed by subcutaneous immunotherapy|PROCEDURE: SCIT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DETERMINE-preserved - Dapagliflozin Effect on Exercise Capacity Using a 6-minute Walk Test in Patients With Heart Failure With Preserved Ejection Fraction
Status: COMPLETED
Conditions: Heart Failure With Preserved Ejection Fraction (HFpEF)
Interventions: DRUG: Dapagliflozin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Imaging of a PET Positive Lymph Node(s) Using 18FDG and a Dual-Mode, Hand-Held Intraoperative Imager
Status: WITHDRAWN
Conditions: Head and Neck Neoplasms
Interventions: DEVICE: Imaging Beta Probe (IBP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase I Trial of Vandetanib (AZD6474) and Selumetinib (AZD6244) for Solid Tumours Including Non Small Cell Lung Cancer (VanSel-1)
Status: COMPLETED
Conditions: Cancer|Non Small Cell Lung Cancer
Interventions: DRUG: Vandetanib, Selumetinib|DRUG: Vandetanib, Selumetinib|DRUG: Vandetanib, Selumetinib|DRUG: Vandetanib, Selumetinib|DRUG: Vandetanib, Selumetinib|DRUG: Vandetanib, Selumetinib|DRUG: Vandetanib, Selumetinib|DRUG: Vandetanib, Selumetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Pharmacodynamics Study of BCD-033 Compared to Rebif® in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Interferon beta-1a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Propofol Versus Fentanyl and Midazolam in Pediatric Patients Requiring Mechanical Ventilation and Sedation Therapy
Status: COMPLETED
Conditions: Respiration Disorders
Interventions: DRUG: fentanyl|DRUG: Midazolam|DRUG: propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Paclitaxel-eluting Balloon, -Stent vs. Plain Angioplasty for Drug-eluting Stent Restenosis
Status: COMPLETED
Conditions: Heart Disease|Ischemia|Restenosis
Interventions: DEVICE: Taxus stent|DEVICE: SeQuent Please|DEVICE: Conventional Balloon Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Assessing PTI-428 Safety, Tolerability, and Pharmacokinetics in Subjects With Cystic Fibrosis on KALYDECO® as Background Therapy
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: PTI-428|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Myfortic vs. Cellcept in Kidney Transplant Recipients
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DRUG: Mycophenolate Sodium Delayed Release Tablets|DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxygen Consumption (VO2), Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit (ICU)
Status: RECRUITING
Conditions: Critical Illness|Intensive Care Unit|Oxygen Consumption|Weaning Failure|Mechanical Ventilation|Spontaneous Breathing Trial
Interventions: DIAGNOSTIC_TEST: Spontaneous Breathing Trial
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Study of Approved and Investigational Contact Lenses
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: Senofilcon C Contact Lens|DEVICE: Comfilcon A Contact Lens|DEVICE: Lotrafilcon B Contact Lens|DEVICE: Samfilcon A Contact Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The COACH Project: Combined Online Assistance for Caregiver Health
Status: UNKNOWN
Conditions: Traumas, Brain|Alzheimer Disease|Dementia|Head Injury|Concussion, Brain|TBI
Interventions: BEHAVIORAL: Combined Aerobic and Resistance Exercise + Caregiver Skills Training|BEHAVIORAL: Stretching Balance and Flexibility + Caregiver Skills Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Demonstration of Broncholytic Effects in Subjects With Obstructive Airway Diseases by Low Frequency Ultrasound
Status: COMPLETED
Conditions: Healthy Volunteers|COPD GOLD I to IV|Asthma GINA 1 to 4
Interventions: DEVICE: Low frequency ultrasound spectroscopy after broncholysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Peer-coaching to Teach Faculty Surgeons an Advanced Laparoscopic Skill
Status: COMPLETED
Conditions: Coaching|Technical Skill|Laparoscopy
Interventions: BEHAVIORAL: conventional training|BEHAVIORAL: peer-coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Implementation Pilot of Preoperative CGA Before Major Surgery
Status: NOT_YET_RECRUITING
Conditions: Surgery|Geriatric Assessment|Health Services Research|Implementation Science
Interventions: OTHER: Implementation Package for CGA|OTHER: Routine Clinical Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Epinephrine Dose: Optimal Versus Standard Evaluation Trial
Status: RECRUITING
Conditions: Cardiac Arrest, Out-Of-Hospital|Sudden Cardiac Arrest|Ventricular Fibrillation|Ventricular Tachycardia-Pulseless
Interventions: DRUG: Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vagal Response and Cardiac Autonomic Modulation. Insides From Cryoballoon Ablation
Status: COMPLETED
Conditions: Vagal Nerve Stimulation|Autonomic Nervous System|Catheter Ablation
Interventions: PROCEDURE: cryoballoon-based pulmonary veins isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of MyoStrain™ in Clinical Practice
Status: COMPLETED
Conditions: Cardiac Failure|Coronary Artery Disease|Sarcoidosis|Amyloidosis|Lupus|Myocarditis|Drug Toxicity
Interventions: PROCEDURE: Diagnostic Test: Myostrain
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multimodal Neuroimaging of Alcohol Cues, Cortisol Response, and Compulsive Motivation
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: DRUG: Intravenous blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Apatinib Combined With Docetaxel in the Treatment of Advanced Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Advanced Esophageal Squamous Carcinoma
Interventions: DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Long-term Administration of Mometasone Furoate Nasal Spray in Pediatric Subjects With Perennial Allergic Rhinitis (Study P06333AM1)
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial
Interventions: DRUG: mometasone furoate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of PDL-0101 in Patients With Hyperlipidemias: a Pilot Study.
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: OTHER: PD-L0101|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Left Bundle Branch Pacing on Outcomes and Ventricular Remodeling in Biventricular CRT Nonresponders
Status: NOT_YET_RECRUITING
Conditions: Heart Failure|Left Bundle-Branch Block|Ischemic Cardiomyopathy|Non-ischemic Dilated Cardiomyopathy|Left Ventricular Dysfunction|Left Ventricle Remodeling
Interventions: DEVICE: Cardiac Resynchronization Therapy Devices with Defibrillator Function (CRT-D) or CRT-D Leads Replacement|DEVICE: CRT-D or CRT-D Leads Replacement with New Lead Implantation to Left Bundle Branch and Inactivation of Conventional Right and Left Ventricular Pacing|DEVICE: CRT-D or CRT-D Leads Replacement with New Lead Implantation to Left Bundle Branch and Inactivation of Conventional Right Ventricular Pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project STAMINA (Syringe Service Telemedicine Access for Medication-assisted Intervention Through NAvigation)
Status: COMPLETED
Conditions: Opioid-use Disorder
Interventions: BEHAVIORAL: Telemedicine Linkage Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Incidence of 30 Day Return to Hospital Following Same Day Discharge Total Hip Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis, Hip|Arthroplasty Complications|Complication of Surgical Procedure|Perioperative Complication
Interventions: OTHER: Eligible for Same Day Discharge|PROCEDURE: Primary Single Joint Total Hip Arthroplasty|OTHER: Discharge Same Day
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose Finding Trial to Assess the Efficacy and Safety of SOTB07 in Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: SOTB07|DRUG: SOTB07|DRUG: placebo|DRUG: montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label Phase I/II Study of JR-446 in Mucopolysaccharidosis Type IIIB
Status: NOT_YET_RECRUITING
Conditions: Mucopolysaccharidosis III-B
Interventions: DRUG: JR-446
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Super Skills for Life Effectiveness in Clinical Settings
Status: COMPLETED
Conditions: Depressive Disorder|Depressive Symptoms|Trauma and Stressor Related Disorders|Anxiety Disorders and Symptoms|Anxiety Disorders|Mood Disorders|Emotional Disorder
Interventions: BEHAVIORAL: Super Skills for Life
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Infracoccygeal Botox for Dyssynergia
Status: COMPLETED
Conditions: Dyssynergic Defaecation|Evacuation Disorder|Anismus|Defecation Disorder
Interventions: PROCEDURE: Percutaneous infracoccygeal Botulinum toxin injection to puborectalis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Site Selection for Intracutaneous Saline Delivery
Status: COMPLETED
Conditions: Intracutaneous Drug Delivery
Interventions: DEVICE: Injection to deltoid|DEVICE: Injection to forearm|DEVICE: Injection to thigh
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Alcohol Brief Intervention Integrated With Mobile Chat-based Support for Risky Drinkers in Emergency Departments
Status: UNKNOWN
Conditions: Alcohol Misuse
Interventions: BEHAVIORAL: Alcohol brief intervention|BEHAVIORAL: 12-page health warning leaflet|BEHAVIORAL: Regular messages through Instant Messaging (IM)|BEHAVIORAL: Real-time chat-based support through IM Apps|BEHAVIORAL: General health through IM Apps|BEHAVIORAL: AUDIT score interpretation sheet adapted from the Department of Health of Hong Kong
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Thermal Spa Short Residential Program for Prevention of Work-related Stress / Burn-out on Biomarkers of Stress - A Proof of Concept Study
Status: UNKNOWN
Conditions: Stress|Burn Out|Heart Rate Variability
Interventions: BEHAVIORAL: 6 days spa residential program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: AT278, NovoRapid® and Humulin® R (U500) in Glucose Clamp Study
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: AT278|DRUG: NovoRapid|DRUG: Humulin R 500 UNT/ML Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Lavender vs Vanilla Essential Oil as Complementary Analgesia for Frenotomy in Healthy Newborns
Status: UNKNOWN
Conditions: Ankyloglossia
Interventions: DIETARY_SUPPLEMENT: Case (use of inhaled vanilla essential oil)|DIETARY_SUPPLEMENT: Control (use of inhaled lavender essential oil)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Dihydropyridine Calcium Channel Blockers Versus Hydrochlorothiazide
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension
Interventions: DRUG: Dihydropyridine calcium channel blocker|DRUG: Hydrochlorothiazide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Anlotinib in Patients With Advanced Gastrointestinal Stromal Tumor After Failure of Imatinib: a Prospective, Single Arm and Multicenter Trial
Status: UNKNOWN
Conditions: Gastrointestinal Stromal Tumors
Interventions: DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Daily Oral Iron Supplementation for Replenishment of Depleted Iron in Adults
Status: COMPLETED
Conditions: Iron-deficiency|Iron Deficiency Anemia
Interventions: DIETARY_SUPPLEMENT: Ferrous Sulfate Capsules|DIETARY_SUPPLEMENT: >Your< Iron Forte Capsules|DIETARY_SUPPLEMENT: >Your< Iron Forte Liquid|OTHER: Blank Capsules|OTHER: Blank Liquid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Trial of RNActive®-Derived Cancer Vaccine and Local Radiation in in Stage IV Non Small Cell Lung Cancer (NSCLC)
Status: TERMINATED
Conditions: Non-Small Cell Lung Carcinoma
Interventions: BIOLOGICAL: CV9202|RADIATION: local radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Clinical Study of Azelaic Acid Gel 15% in Patients With Moderate Facial Rosacea
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: Azelaic acid|DRUG: Vehicle|DRUG: Finacea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of a Brain-Computer Interface for Stroke Neurological Upper Limb Rehabilitation
Status: COMPLETED
Conditions: Stroke, Ischemic|Stroke
Interventions: DEVICE: Brain-Computer Interface|DEVICE: Sham Brain-Computer Interface
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Amantadine for the Treatment of Traumatic Brain Injury Irritability and Aggression: A Multi-site Study
Status: COMPLETED
Conditions: Brain Injury|Aggression
Interventions: DRUG: Amantadine Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Assessment of Oral Administration Vs. Oral Spray of a Cannabinoids (Tetrahydrocannabinol and Cannabidiol)
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Sativex buccal spray|DRUG: CBD-THC-Piperine-PNL capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influence of Culture Media on Clinical Outcomes in Poor Responders or Severe Male Infertility
Status: UNKNOWN
Conditions: Poor Responder|Severe Male Infertility|Embryo Development|Blastocyst|Culture Media
Interventions: DRUG: sequential medium|DRUG: 1-step medium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Soticlestat as an Add-on Therapy in Children and Young Adults With Dravet Syndrome
Status: COMPLETED
Conditions: Dravet Syndrome (DS)
Interventions: DRUG: Soticlestat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of a Portion Control Food Tool to Induce Weight Loss in Obese Type 2 Diabetics.
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Obesity
Interventions: DEVICE: The Diet Plate (R) TM portion control plate and bowl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral Supplements on the Nutritional Status of Locally Advanced Nasopharyngeal Carcinoma Patients
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma
Interventions: DIETARY_SUPPLEMENT: Healing Elements,Methuselah Medical Technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blu Light for Ulcers Reduction
Status: COMPLETED
Conditions: Leg Ulcers Venous|Dehiscence, Surgical Wound
Interventions: DEVICE: Illumination with blue light (400-430nm) for 60 seconds with a power density of 120mW/sqcm (EmoLED device)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of IgPro20 and IgPro10 in Adults With Systemic Sclerosis (SSc)
Status: COMPLETED
Conditions: Diffuse Cutaneous Systemic Sclerosis
Interventions: BIOLOGICAL: IgPro20|BIOLOGICAL: IgPro10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-CD19 CAR-T Therapy Combine With HSCT to Treat MRD+ B-cell Malignancies
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia|B Cell Lymphoma
Interventions: GENETIC: Second generation CAR-T cells|PROCEDURE: Hematological stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Pharmacokinetics of Lemborexant (E2006) and Its Metabolites in Subjects With Mild and Moderate Hepatic Impairment Compared to Healthy Subjects
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: Lemborexant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Monotherapy With Noradrenaline and Terlipressin in Patients of Cirrhosis With Septic Shock Admitted to Intensive Care Unit
Status: COMPLETED
Conditions: Cirrhosis With Septic Shock
Interventions: DRUG: Terlipressin|DRUG: Noradrenaline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Complete Removable Prosthetic Rehabilitations Performed by an Innovative DDTENS Protocol, on the Quality of Masticatory Function and the Management of Completely Edentulous Patients
Status: RECRUITING
Conditions: Disorder of Maxillary and Mandibular Dental Arch Relationship
Interventions: OTHER: DD-TENS system|OTHER: Gold Standard|OTHER: Digital Denture system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Glutamate for Metabolic Intervention in Coronary Surgery II
Status: COMPLETED
Conditions: Coronary Artery Bypass Surgery|Postoperative Complications|Heart Failure
Interventions: DRUG: glutamate infusion|DRUG: saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose-Ranging Study of ST-920, an AAV2/6 Human Alpha Galactosidase A Gene Therapy in Subjects With Fabry Disease (STAAR)
Status: ACTIVE_NOT_RECRUITING
Conditions: Fabry Disease
Interventions: BIOLOGICAL: ST-920
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability, Efficacy, Pharmacokinetic and Pharmacodynamic Study of Three Doses of BI 187004 Over 28 Days in Patients With Type 2 Diabetes Mellitus With and Without Metformin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: BI 187004|DRUG: Placebo|DRUG: BI 187004|DRUG: BI 187004|DRUG: BI 187004
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Nivolumab Plus Ipilimumab in Patients With Salivary Gland Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Salivary Gland Cancer
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GnRH Agonist (GnRHa) Withdrawal at Late Stage of Long Protocol and the Incidence of Ovarian Hyper-stimulation
Status: UNKNOWN
Conditions: Infertile High-risk Patients With Polycystic Ovaries
Interventions: DRUG: a drug withdrawal during the long protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sublingual Versus Endovenous Fentanyl for Pain Treatment in Trauma Patients in the Emergency Room
Status: COMPLETED
Conditions: Acute Pain Due to Trauma
Interventions: DRUG: Fentanyl sublingual|DRUG: Fentanyl ev|DRUG: Placebo sublingual|DRUG: Placebo ev
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BKM120 + mFOLFOX6 in Advanced Solid Tumors With Expansion Cohort Pancreatic Cancer
Status: COMPLETED
Conditions: Advanced Solid Tumors|Metastatic Colorectal Cancer|Metastatic Pancreatic Cancer
Interventions: DRUG: BKM120|DRUG: mFOLFOX6
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: D-PLEX 311: Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection
Status: COMPLETED
Conditions: Surgical Site Infection|Colon Surgery|Abdominal Surgery|Post-Op Infection
Interventions: DRUG: D-PLEX|OTHER: Standard of Care (SoC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Rivastigmine Bioequivalence Trial With Multiple Applications of Transdermal Patches (9.5 mg/24 h)
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Rivastigmine twice-weekly 9,5 mg/24 h|DRUG: Exelon® 9.5 mg/24 h
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Mosunetuzumab|DRUG: Tocilizumab|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Dietary Education of Low Sodium and High Potassium Consumption
Status: UNKNOWN
Conditions: Prehypertension|Hypertension
Interventions: BEHAVIORAL: dietary education of low sodium and high potassium consumption|BEHAVIORAL: dietary education of low sodium consumption only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of ERAS on Pancreaticoduodenectomy (v2.0)
Status: NOT_YET_RECRUITING
Conditions: Periampullary Cancer|Borderline Malignancy Tumor
Interventions: OTHER: ERAS perioperative management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ-64264681 and JNJ-67856633 in Participants With Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma, Non-Hodgkin|Chronic Lymphocytic Leukemia
Interventions: DRUG: JNJ-64264681|DRUG: JNJ-67856633
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Polymyxin B Hemoperfusion on Severe Sepsis Secondary to Pneumonia or Urinary Tract Infection
Status: TERMINATED
Conditions: Sepsis
Interventions: DEVICE: Toraymyxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Switching Mediterranean Consumers to Mediterranean Sustainable Healthy Dietary Patterns
Status: ENROLLING_BY_INVITATION
Conditions: Healthy Subjects|Behavior, Health|Family
Interventions: DEVICE: AI-based Apps|BEHAVIORAL: Mediterranean-based diet toolkit and activities|OTHER: Healthy plant-based snacks|OTHER: AI-based Apps + Mediterranean-based diet toolkit and activities|OTHER: AI-based Apps + Healthy plant-based snacks|OTHER: Mediterranean-based diet toolkit and activities + Healthy plant-based snacks|OTHER: AI-based Apps + Mediterranean-based diet toolkit and activities + Healthy plant-based snacks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Exendin-(9-39) on Glycemic Control in Subjects With Congenital Hyperinsulinism
Status: COMPLETED
Conditions: Congenital Hyperinsulinism
Interventions: DRUG: Exendin-(9-39)|OTHER: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Turkish Validity and Reliability of The Helkimo Index for Diagnosis of Temporomandibular Disorders
Status: NOT_YET_RECRUITING
Conditions: Temporomandibular Disorder
Interventions: DIAGNOSTIC_TEST: Helkimo Index
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Is Fetal Hemoglobin a Key for Improvement of Hypoxia and Saving Last Breath in COVID-19 Patient?. A Pilot Study.
Status: UNKNOWN
Conditions: COVID-19 Acute Respiratory Distress Syndrome
Interventions: PROCEDURE: fetal blood transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Response to an Intervention With Omega-3 (RIO - Study)
Status: RECRUITING
Conditions: Overweight|Hypertriglyceridemia
Interventions: DIETARY_SUPPLEMENT: Omega-3|DIETARY_SUPPLEMENT: HOSO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effectiveness of Laser Acupuncture and Standard Medication Therapy on Mandibular Post-Odontectomy Patients
Status: COMPLETED
Conditions: Laser Acupuncture|Impacted Third Molar Tooth
Interventions: DEVICE: Laser Acupuncture and Standard Medication|DEVICE: Sham Laser Acupuncture and Standard Medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pancreatic Exocrine Insufficiency and Pancreatic Enzyme Supplementation in Critically Ill Adult Patients
Status: COMPLETED
Conditions: Critical Illness|Sepsis|Diabetes|Cardiac Arrest|Acute Renal Failure|Shock
Interventions: DIETARY_SUPPLEMENT: Enteral nutrition (EN)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Interventions to Improve Pain Relief, Perceived Anxiety and Recovery in Participants Receiving Office Based Surgery
Status: COMPLETED
Conditions: Varicose Veins|Pain
Interventions: OTHER: Interaction|OTHER: Music|BEHAVIORAL: Touch - stress balls|BEHAVIORAL: DVD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Bridging Study Between V181 (Dengue Quadrivalent Vaccine rDENVΔ30 [Live, Attenuated]) to Butantan Dengue Vaccine (Butantan-DV) in Healthy Adults 18 to 50 Years of Age in Brazil (V181-002)
Status: ACTIVE_NOT_RECRUITING
Conditions: Dengue
Interventions: BIOLOGICAL: V181|BIOLOGICAL: Butantan-DV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Guo's False Lumen Embolization : The First in Man Study of WeFlow-EndoSeal Aorta Vascular Plug System
Status: RECRUITING
Conditions: Aortic Dissection Aneurysm
Interventions: DEVICE: Aorta Vascular Plug System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intensity, Specificity and Reversibility of Inspiratory Muscle Training in Asthmatics
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: High-intensity IMT|DEVICE: Low-intensity IMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT