pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Reactogenicity Study of GlaxoSmithKline (GSK) Biologicals' Investigational Respiratory Syncytial Virus (RSV) Vaccine (GSK3003891A) in Healthy Women
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: RSV vaccine GSK3003891A|BIOLOGICAL: Boostrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RHA® 3 Versus Restylane-L® for Lip Augmentation
Status: COMPLETED
Conditions: Lip Augmentation|Lip
Interventions: DEVICE: RHA 3|DEVICE: Restylane-L
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-dependent Effects of VAC BNO 1095 on Cyclic Mastodynia and Premenstrual Syndrome
Status: COMPLETED
Conditions: Cyclic Mastodynia|Premenstrual Syndrome
Interventions: DRUG: VAC BNO 1095 film coated tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation Effects of Treatment With IL-6R Inhibitor on Clinical Response and Biomarkers in Patients With Rheumatoid Arthritis (RA) Not Responding to DMARDs and/or a First Biological Agent.
Status: UNKNOWN
Conditions: Rheumatoid Arthritis (RA)
Interventions: OTHER: Biomarkers Measures
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of a Cell Culture Process for the Production of Human T-lymphocyte Precursors
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: PROCEDURE: Collection of mobilized hematopoietic stem cells (apheresis products) from healthy volunteers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Cold and Kinesio Taping in Individuals With Rotator Cuff Tendonitis
Status: COMPLETED
Conditions: Rotator Cuff Tendinitis
Interventions: OTHER: Kinesio Taping (KT)|OTHER: Cold Therapy (CT)|OTHER: standardized home exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Atezolizumab Concurrent With Radiotherapy in Patients With Muscle-invasive Bladder cáncer
Status: ACTIVE_NOT_RECRUITING
Conditions: Bladder Cancer
Interventions: DRUG: Atezolizumab Injection [Tecentriq]|RADIATION: External Beam Radiation Therapy (EBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Connected Scales to Optimize the Maintenance of Weight Lost After Bariatric Surgery and Limit Failures and Reoperations
Status: NOT_YET_RECRUITING
Conditions: Obesity, Severe|Surgery
Interventions: DEVICE: Body Comp Pro connected scale (Withings manufacturer)|OTHER: Alert generation by remote plateform
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Repetitive Transcranial Magnetic Stimulation in Traumatic Brain Injury
Status: UNKNOWN
Conditions: Perceptual Disorders|Traumatic Brain Injury
Interventions: DEVICE: Inhibitory repetitive transcranial magnetic stimulation|DEVICE: Sham Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Triggering Oocyte Maturation in Normoresponders Using Double Trigger or HCG Trigger
Status: NOT_YET_RECRUITING
Conditions: Infertility
Interventions: DRUG: Double trigger|DRUG: HCG trigger
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate D1 Receptor Occupancy (RO) Following Single Dose of PF-06412562 In Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 30 mg PF-06412562|DRUG: PF-06412562|DRUG: PF-06412562
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Double Blind Placebo Controlled Trial of Sodium Thiosulfate for the Treatment of Pain Associated With Calcific Uremic Arteriolopath
Status: TERMINATED
Conditions: Calciphylaxis|Calcific Uremic Arteriolopathy
Interventions: DRUG: Sodium thiosulfate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Regorafenib in Combination With TAS-102 in Subjects With Metastatic Colorectal Cancer Who Have Progressed After Standard Therapy
Status: COMPLETED
Conditions: Pretreated Metastatic Colorectal Cancer
Interventions: DRUG: TAS 102|DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carnosine for Peripheral Vascular Disease
Status: UNKNOWN
Conditions: Peripheral Arterial Disease
Interventions: DRUG: Carnosine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of NC-6004 in Combination With 5-FU and Cetuximab in Patients With Head and Neck Cancer
Status: TERMINATED
Conditions: Head and Neck Neoplasms
Interventions: DRUG: NC-6004|DRUG: Cetuximab|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atezolizumab and Bevacizumab in Treating Patients With Rare Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Appendix Adenocarcinoma|Human Papillomavirus-Related Anal Squamous Cell Carcinoma|Human Papillomavirus-Related Cervical Squamous Cell Carcinoma|Human Papillomavirus-Related Squamous Cell Carcinoma of the Penis|Human Papillomavirus-Related Vulvar Squamous Cell Carcinoma|Neuroendocrine Carcinoma|Pancreatic Neuroendocrine Tumor|Recurrent Merkel Cell Carcinoma|Recurrent Nasopharynx Carcinoma|Recurrent Peritoneal Malignant Mesothelioma|Recurrent Pleural Malignant Mesothelioma|Stage III Merkel Cell Carcinoma AJCC v7|Stage III Nasopharyngeal Carcinoma AJCC v7|Stage III Pleural Malignant Mesothelioma AJCC v7|Stage IV Merkel Cell Carcinoma AJCC v7|Stage IV Nasopharyngeal Carcinoma AJCC v7|Stage IV Pleural Malignant Mesothelioma AJCC v7|Stage IVA Nasopharyngeal Carcinoma AJCC v7|Stage IVB Nasopharyngeal Carcinoma AJCC v7|Stage IVC Nasopharyngeal Carcinoma AJCC v7|Vaginal Squamous Cell Carcinoma, Not Otherwise Specified
Interventions: DRUG: Atezolizumab|BIOLOGICAL: Bevacizumab|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abutment Macro Design and Peri-implant Tissues
Status: COMPLETED
Conditions: Edentulous
Interventions: OTHER: Abutment with concave subcritical contour|OTHER: Abutment with convex subcritical contour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Body Fat Reducing Effect and Safety of GTB1
Status: COMPLETED
Conditions: Body Fat
Interventions: DIETARY_SUPPLEMENT: GTB1|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Sodium Pyruvate Therapy in COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: sodium pyruvate in 0.9% sodium chloride solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Novel Obesity Prevention Program for High-Risk Infants in Primary Care
Status: RECRUITING
Conditions: Obesity|Obesity, Childhood|Weight Gain|Weight Gain Trajectory
Interventions: BEHAVIORAL: THRIVE 2.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Enzalutamide With and Without Sorafenib in Advanced Hepatocellular Carcinoma Patients
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Enzalutamide|DRUG: Enzalutamide with Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Xperguide vs. Conventional Methods During Percutaneous Image Guided Procedures
Status: TERMINATED
Conditions: Infection|Cancer|Neoplasm|Empyema|Granuloma
Interventions: DEVICE: Cone-beam computed tomography (CT)|DEVICE: Conventional Computed Tomography (CT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: First-void Urine Samples for the Follow-up of Women Treated for High-grade Cervical Intraepithelial Neoplasia (CIN)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Cancer
Interventions: DEVICE: Colli-Pee|DEVICE: Qvintip
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of the Gore® Excluder® Iliac Branch Platform and Analysis of Its Behavior in Combination With the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis (IBERVIX)
Status: UNKNOWN
Conditions: Aortic Aneurysm|Iliac Aneurysm
Interventions: DEVICE: GORE® EXCLUDER® Iliac Branch Endoprosthesis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of a High Fiber Diet and High-Intensity Interval Exercise in Patients With HFpEF
Status: RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: BEHAVIORAL: High Intensity Interval Exercise|BEHAVIORAL: Dietary Approaches to Stop Hypertension (DASH) Diet|BEHAVIORAL: Exercise + DASH Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intensive Care Unit (ICU) Diaries as a Therapeutic Intervention for Post Traumatic Stress Disorder (PTSD) Following Critical Illness
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: OTHER: ICU Diary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clobazam in Patients With Lennox-Gastaut Syndrome
Status: COMPLETED
Conditions: Epilepsy|Epilepsy, Generalized|Seizures
Interventions: DRUG: Clobazam Low Dose|DRUG: Clobazam Medium Dose|DRUG: Clobazam High Dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BI 425809 in Patients With Cognitive Impairment Due to Alzheimer's Disease.
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: BI 425809 dose 1|DRUG: BI 425809 dose 2|DRUG: BI 425809 dose 3|DRUG: BI 425809 dose 4|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Schistosome and Intestinal Worm Infections and Malaria Morbidity Among School and Pre-school Children in, Tanzania
Status: COMPLETED
Conditions: Anaemia|Malaria|Hepatosplenomegaly
Interventions: DRUG: Albendazole and praziquantel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Abarelix Versus Goserelin Plus Bicalutamide in Patients With Advanced or Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Abarelix|DRUG: Goserelin plus Bicalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aminophylline for Patients With Post-Dural Puncture Headache
Status: COMPLETED
Conditions: Post-dural Puncture Headache
Interventions: DRUG: Aminophylline|DRUG: isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Prucalopride for the Treatment of Chronic Constipation
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: Prucalopride|DRUG: Prucalopride|DRUG: Prucalopride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Very Low Protein Diet and Renal Death in Chronic Kidney Disease (CKD)-ERIKA Study
Status: UNKNOWN
Conditions: Chronic Renal Insufficiency
Interventions: BEHAVIORAL: Very low protein diet|BEHAVIORAL: Low protein diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MESO-CAR T Cells Therapy for Relapsed and Refractory Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: BIOLOGICAL: anti-MESO CAR-T cells|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab With Epstein Barr Virus Specific T Cells (EBVSTS), Relapsed/Refractory EBV Positive Lymphoma (PREVALE)
Status: COMPLETED
Conditions: NonHodgkin Lymphoma|Lymphoproliferative Disorders|EBV Related Lymphoma|EBV-Related PTLD|Hodgkin Lymphoma|EBV Related Non-Hodgkin's Lymphoma|EBV Related Hodgkin's Lymphoma
Interventions: BIOLOGICAL: EBVST Cells|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic/Pharmacodynamic Inhaler Comparison Study in Healthy Volunteers
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone/formoterol BAI|DRUG: Formoterol|DRUG: Fluticasone/formoterol PMDI without spacer|DRUG: Fluticasone/formoterol PMDI with spacer|DRUG: Fluticasone/formoterol PMDI without spacer low dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Shock Wave Lithotripsy for Treatment of Large Pediatric Renal Pelvic Stone Burden More Than 2 cm
Status: COMPLETED
Conditions: Determine the Efficacy and Safety of SWL in Renal Stones Larger Than 2 cm in Pediatric Age Group
Interventions: DEVICE: extracorporeal shock wave lithotripsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adoptive Immunotherapy With Activated Marrow Infiltrating Lymphocytes and Cyclophosphamide Graft-Versus-Host Disease Prophylaxis in Patients With Relapse of Hematologic Malignancies After Allogeneic Hematopoietic Cell Transplantation
Status: COMPLETED
Conditions: Hematologic Malignancies|Graft-Versus-Host Disease
Interventions: BIOLOGICAL: Activated PTCy-MILs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Predictive Biomarkers for Response to Biologic Therapies and Tofacitinib in Inflammatory Bowel Disease
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases|Crohn Disease|Ulcerative Colitis
Interventions: BIOLOGICAL: Infliximab or adalimumab or golimumab or vedolizumab or ustekinumab or tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of SO-C101 and SO-C101 in Combination With Pembro in Adult Patients With Advanced/Metastatic Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Thyroid|Renal Cell Carcinoma|Non Small Cell Lung Cancer|Small-cell Lung Cancer|Bladder Cancer|Melanoma|Merkel Cell Carcinoma|Skin Squamous Cell Carcinoma|Microsatellite Instability High|Triple Negative Breast Cancer|Mesothelioma|Thymic Cancer|Cervical Cancer|Biliary Tract Cancer|Hepatocellular Carcinoma|Ovarian Cancer|Gastric Cancer|Head and Neck Squamous Cell Carcinoma|Anal Cancer
Interventions: DRUG: SO-C101|DRUG: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypoglossal Acupuncture for Dysgeusia in Patients Undergoing Chemotherapy
Status: RECRUITING
Conditions: Acupuncture|Taste Disorders|Dysgeusia|Chemotherapy|Cancer
Interventions: OTHER: Hypoglossal acupuncture|OTHER: Sham acupuncture|BEHAVIORAL: Dietary recommendations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Pembrolizumab in Cutaneous Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Cutaneous Squamous Cell Carcinoma of the Head and Neck|Head and Neck Cancer
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of COVID-19 mRNA Vaccine in Regions With SARS-CoV-2 Variants of Concern
Status: COMPLETED
Conditions: SARS-CoV-2 Infection|HIV Infections|COVID-19
Interventions: BIOLOGICAL: Moderna mRNA-1273|BIOLOGICAL: Vaccine 3 Dose|BIOLOGICAL: Vaccine 2 Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Pharmacokinetics of LEO 90105 (Calcipotriol Hydrate Plus Betamethasone Dipropionate) in Japanese Subjects With Extensive Psoriasis Vulgaris
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: LEO 90105
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk Assessment of Proximal Contact Loss Between Implant-supported Prostheses and Adjacent Teeth.
Status: NOT_YET_RECRUITING
Conditions: Peri-Implantitis and Peri-implant Mucositis
Interventions: BEHAVIORAL: plaque index assessment, periodontal probing, Bleeding on probing (BOP), Prosthetic adjacency check, initial occlusal contact, maximum occlusal contact, and filling of the cusps.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Wrist Cooling for Hot Flashes Clinical Trial
Status: RECRUITING
Conditions: Hot Flashes
Interventions: DEVICE: Wrist cooling device with cooling plate|DEVICE: Wrist fan activating device without cooling plate|OTHER: Hot Flash Diary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effect of Exercise Protocol Determined According to Metabolic Rate in Early Burn Patients on Coagulation, Fibrinolytic Activity and Functional Capacity
Status: COMPLETED
Conditions: Burns
Interventions: OTHER: Control Group/1st group ( standard physiotherapy|OTHER: 2nd group- Standard physiotherapy + bicycle ergometer|OTHER: 3rd group- Standard physiotherapy + exercise protocol to be developed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lipiodol-TACE With Idarubicin Based On a Specific Emulsion Ratio for Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: cTACE(conventional transarterial chemoembolization)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neuropsychological Consultation as Part of Pediatric Diabetes Care: Does it Improve Glycemic Control and Family Functioning?
Status: COMPLETED
Conditions: Diabetes|Glycinemia
Interventions: BEHAVIORAL: Usual standard of care|BEHAVIORAL: Neuropsychological Consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predicting Olaparib Sensitivity in Patients With Unresectable Locally Advanced/Metastatic HER2-negative Breast Cancer.
Status: RECRUITING
Conditions: HER2-negative Breast Cancer|Metastatic Breast Cancer|Triple Negative Breast Cancer
Interventions: DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Ocular Blood Flow in Patients With Glaucoma and/or Obstructive Sleep Apnea Syndrome (OSAS)
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea Syndrome
Interventions: DEVICE: measurement of ocular blood flow
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Influence of High and Low Salt on Exosomes in the Urine
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: High salt diet followed by low salt diet|DIETARY_SUPPLEMENT: Low salt diet followed by high salt diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of SAMe in Patients With Alcoholic Liver Disease
Status: COMPLETED
Conditions: Liver Disease, Alcoholic
Interventions: DRUG: S-adenosylmethionine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of EMDR in the Treatment of Depression and Comorbid Anxiety
Status: UNKNOWN
Conditions: Depression|Anxiety
Interventions: BEHAVIORAL: Eye Movement Desensitization and Reprocessing (EMDR) psychotherapy|BEHAVIORAL: Counselling as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Family Smoking Cessation in Romania Using Pregnancy as a Window of Opportunity
Status: COMPLETED
Conditions: Tobacco Smoking|Pregnancy
Interventions: BEHAVIORAL: Adapted/enhanced MAPS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mesothelin and Osteopontin as Diagnostic Markers in Patients With Mesothelioma or Atypical Mesothelial Hyperplasia
Status: UNKNOWN
Conditions: Malignant Mesothelioma|Metastatic Cancer
Interventions: OTHER: laboratory biomarker analysis|PROCEDURE: study of high risk factors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Transthoracic Electrical Bioimpedance and Pulse Contour Analysis in Renal Transplantation Patients
Status: COMPLETED
Conditions: Hemodynamic Monitoring
Interventions: DEVICE: Transthoracic Electrical Bioimpedance|DEVICE: Pulse Contour Analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: REmote iSchemic condItioning in Lymphoma PatIents REceiving ANthraCyclinEs
Status: RECRUITING
Conditions: Anthracycline-induced Cardiac Toxicity|Lymphoma
Interventions: DEVICE: RIPC|DEVICE: Simulated RIPC (Sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Efficacy and Safety of TACI-antibody Fusion Protein Injection (RC18) in Subjects With Inadequate Response to MTX Due to Treat Moderate and Severe Rheumatoid Arthritis.
Status: COMPLETED
Conditions: Moderate and Severe RheumatoId Arthritis
Interventions: BIOLOGICAL: Placebo plus MTX|BIOLOGICAL: RC18 160 mg plus MTX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Dendritic Cell Therapy for Type 1 Diabetes Suppression: A Safety Study
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: BIOLOGICAL: Diabetes-suppressive dendritic cell vaccine|BIOLOGICAL: control dendritic cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Panobinostat (LBH589) as Second-Line Therapy in Patients With Chronic Graft-Versus-Host Disease
Status: WITHDRAWN
Conditions: Chronic Graft-Versus-Host Disease
Interventions: DRUG: LBH589|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Adult Participants to Assess the Pharmacokinetics, Immunogenicity, Safety, and Tolerability of a Ravagalimab Subcutaneous Formulation in a Pre-Filled Syringe
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: Ravagalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Standard Verbal Counseling With or Without a Pictorial Educational Tool for the Reduction of Psychological Morbidity in Patients With Stage 0-IIIA Breast Cancer Receiving Radiation Therapy, COPE Study
Status: RECRUITING
Conditions: Anatomic Stage 0 Breast Cancer AJCC v8|Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage 0 Breast Cancer AJCC v8|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Breast Carcinoma
Interventions: OTHER: Counseling|OTHER: Educational Intervention|BEHAVIORAL: Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Biperiden Trial for Epilepsy Prevention
Status: RECRUITING
Conditions: Brain Injury Traumatic Moderate|Brain Injury Traumatic Severe|Post Traumatic Epilepsy
Interventions: DRUG: Biperiden|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Learning Curve of Double-wire Cannulation Technique During Endoscopic Retrograde Cholangiopancreatography (ERCP)
Status: COMPLETED
Conditions: Biliary Cannulation|Endoscopic Retrograde Cholangiopancreatography
Interventions: PROCEDURE: DWT learning curve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impact of Vitamin D Supplementation on Cardiac Structure and Function
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: Vitamin D3 + fish oil/fish oil placebo|DIETARY_SUPPLEMENT: Vitamin D3 placebo + fish oil/fish oil placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prophylactic Post-Cesarean Incisional Negative-pressure Wound Therapy in Morbidly Obese Patients
Status: UNKNOWN
Conditions: Negative-pressure Wound Therapy|Morbid Obesity|Cesarean Section|Wound Infection
Interventions: DEVICE: Negative-pressure wound therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare Brachial Artery Reactivity and Cardiovascular Risk of a Treatment Simplification by Darunavir/Ritonavir (DRV/r) 800/100 mg Versus a Triple Combination Therapy Containing DRV/r in HIV-1 Infected Patients
Status: COMPLETED
Conditions: Human Immunodeficiency Virus 1
Interventions: DRUG: Darunavir(DRV)|DRUG: Ritonavir|DRUG: 2 nucleoside reverse transcriptase inhibitors (NRTIs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation on Feasibility and Usability of the ABLE Exoskeleton Device for Individuals With Spinal Cord Injury to Perform Skills for Home and Community Environments
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: DEVICE: ABLE Exoskeleton
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Comparison of Two Oral Appliances in the Treatment of Sleep Apnea Syndrome
Status: TERMINATED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Herbst (propulsion type oral appliance)|DEVICE: Retention type appliance (ORM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: ICP-022 Versus Chlorambucil Combined With Rituximab in the Treatment of Untreated CLL/SLL
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: ICP-022|DRUG: Chlorambucil|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of the Serotonin 5-HT2A Receptor in Mescaline-induced Altered States of Consciousness
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Placebo|DRUG: Mescaline 100mg|DRUG: Mescaline 200mg|DRUG: Mescaline 400mg|DRUG: Mescaline 800mg|DRUG: Mescaline 800mg + Ketanserin 40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Outcome of Autosomal Dominant Polycystic Kidney Disease Patients on Peritoneal Dialysis: a National Retrospective Study Based on Two French Registries (the French Language Peritoneal Dialysis Registry and the French Renal Epidemiology and Information Network).
Status: COMPLETED
Conditions: Polycystic Kidney Diseases
Interventions: OTHER: Dialysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose-Finding Study of Afuresertib Administered in Combination With Either Enzalutamide or Aibraterone
Status: WITHDRAWN
Conditions: Cancer
Interventions: DRUG: Afuresertib|DRUG: Enzalutamide|DRUG: Abiraterone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Cinnamomum Verum for Induction of Labor. Double Blind Randomized Clinical Trial
Status: RECRUITING
Conditions: Labor Onset and Length Abnormalities|First Birth
Interventions: DRUG: Cinnamomum Verum oil extract|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Oral ABP-745 Administration in Healthy Volunteers
Status: RECRUITING
Conditions: Gout
Interventions: DRUG: ABP-745|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Short-course HIPEC in Advanced Epithelial Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: PROCEDURE: Cytoreductive Surgery (CRS)|PROCEDURE: Hyperthermic Intraperitoneal Chemotherapy (HIPEC)|DRUG: Neoadjuvant Chemotherapy (NACT)|DRUG: Adjuvant Chemotherapy|PROCEDURE: Fast-track recovery strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lithium, Cord Blood Cells and the Combination in the Treatment of Acute & Sub-acute Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: PROCEDURE: Conventional Treatment|DRUG: Lithium Carbonate Tablet|BIOLOGICAL: Cord Blood Cell|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neurofeedback for Upper-limb Recovery After Stroke
Status: TERMINATED
Conditions: Stroke
Interventions: OTHER: Neurofeedback coupling electroencephalogram and functional MRI in time actual|OTHER: Electroencephalogram-neurofeedback program or Neurofeedback-free mental imaging program with electroencephalogram recording|OTHER: Neurofeedback coupling electroencephalogram and functional MRI in time actual or a neurofeedback-free mental imaging program with electroencephalogram recording
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Phase I: Melphalan, Bendamustine and Carfilzomib for Autologous Transplant in Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Cohort 1: Carfilzomib 15 mg/m2|DRUG: Cohort 2: Carfilzomib 20 mg/m2|DRUG: Cohort 2b: Carfilzomib 20 mg/m2|DRUG: Cohort 3b: Carfilzomib 27 mg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Toripalimab Plus Concurrent Chemo-radiotherapy for Unresectable Locally Recurrent Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma|Chemotherapy|Radiotherapy|PD-1 Treatment
Interventions: DRUG: Toripalimab plus concurrent chemo-radiotherapy|DRUG: Concurrent chemo-radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Functional Electrical Stimulation in Patients Undergoing Coronary Artery Bypass Grafting Surgery
Status: COMPLETED
Conditions: Muscle Wasting
Interventions: DEVICE: Functional Electrical Stimulation (FES)|OTHER: Functional Electrical Stimulation (FES) sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cisplatin, Nab-paclitaxel, Nivolumab With Radiotherapy After Resection of Non-Metastatic Muscle Invasive Bladder Cancer
Status: RECRUITING
Conditions: Muscle-Invasive Bladder Carcinoma
Interventions: DRUG: Nivolumab|DRUG: Nab paclitaxel|DRUG: Cisplatin|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cabergoline Versus Calcium Infusion in Ovarian Hyperstimulation Syndrome Prevention
Status: COMPLETED
Conditions: Ovarian Hyperstimulation
Interventions: DRUG: Oral Cabergoline|DRUG: Calcium Gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Safety and Performance of the MILTA GYNECO Vaginal Probe in Postmenopausal Women With Vaginal Atrophy
Status: COMPLETED
Conditions: Menopause|Urinary Incontinence|Atrophic Vaginitis
Interventions: DEVICE: Photobiomodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Transcranial Direct Current Stimulation Therapy for Bipolar Depression
Status: COMPLETED
Conditions: Depression, Bipolar|Bipolar Disorder|Mood Disorders|Mental Disorder
Interventions: DEVICE: Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Exercise Resistance With Sedentary Interruptions
Status: RECRUITING
Conditions: Sedentary Behavior|Lipid Metabolism Disorder|Exercise
Interventions: BEHAVIORAL: Standing interruptions|BEHAVIORAL: Exercise bout|BEHAVIORAL: Sedentary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CyberKnife Ultra-hypofractionated SBRT for Localized PROStatE cancEr
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: CyberKnife ultra-hypofractionated SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polygraphic Evaluation of the Effects of Different Rapid Maxillary Expansion Appliances on Sleep Quality
Status: COMPLETED
Conditions: Sleep Apnea Syndromes|Palatal Expansion Technique
Interventions: PROCEDURE: Rapid Maxillary Expansion Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism
Status: COMPLETED
Conditions: Quality of Life|Depression
Interventions: DRUG: Triiodothyronine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Parasitological Clearance Rates And Pharmacokinetics Of The Combination Of Azithromycin And Chloroquine In Asymptomatic Pregnant Women With Falciparum Parasitemia In Africa
Status: TERMINATED
Conditions: Asymptomatic Parasitemia In Pregnancy
Interventions: DRUG: Azithromycin plus chloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Immunogenicity of a Prime-Boost Regimen of rVSV-Nipah Virus Vaccine Candidate PHV02 in Healthy Adult Subjects
Status: RECRUITING
Conditions: Nipah Virus Infection
Interventions: BIOLOGICAL: PHV02|BIOLOGICAL: Lactated Ringer's
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Anti-CD20 (Cluster of Differentiation Antigen 20) Therapy to Treat Metastatic Melanoma
Status: COMPLETED
Conditions: Stage III Melanoma|Stage IV Melanoma
Interventions: BIOLOGICAL: Ofatumumab|BIOLOGICAL: Ofatumumab plus Dacarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Patients With Metastatic, Recurrent, or Refractory Neuroblastoma
Status: TERMINATED
Conditions: Neuroblastoma
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CK-2017357 in Patients With Peripheral Artery Disease and Symptomatic Claudication
Status: COMPLETED
Conditions: Intermittent Claudication|Peripheral Artery Disease
Interventions: DRUG: Placebo|DRUG: 375 mg CK-2017357|DRUG: 500 mg CK-2017357
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Efficacy and Safety of Tividenofusp Alfa (DNL310) vs Idursulfase in Pediatric and Young Adult Participants With Neuronopathic (nMPS II) or Non-Neuronopathic Mucopolysaccharidosis Type II (nnMPS II)
Status: RECRUITING
Conditions: Mucopolysaccharidosis II
Interventions: DRUG: tividenofusp alfa|DRUG: idursulfase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Endovascular Therapy for Acute Large Vessel Occlusion With Large Ischemic Core
Status: COMPLETED
Conditions: Mechanical Thrombectomy|Large Ischemic Core
Interventions: PROCEDURE: Endovascular treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Whose Purpose is to Find an Optimal Dose for the Treatment With AK 3012 in Patients With Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis Olsen Grade I/II
Interventions: DRUG: AK 3012
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Double-Blind, Placebo-Controlled Trial of Eefooton in Patients With Chronic Kidney Disease
Status: ENROLLING_BY_INVITATION
Conditions: Chronic Kidney Diseases|Renal Insufficiency, Chronic|Urologic Diseases
Interventions: DIETARY_SUPPLEMENT: Eefooton oral solution|DIETARY_SUPPLEMENT: Placebo oral solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Finnish Vitamin D Trial (FIND)
Status: COMPLETED
Conditions: Cardiovascular Diseases|Cancer
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Calprotectin-Directed Humira® Maintenance Therapy (CADHUM)
Status: WITHDRAWN
Conditions: Crohn's Disease
Interventions: DRUG: Adalimumab|DRUG: Adalimumab PRN|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Oral Naloxone for Treatment of Methadone-induced Constipation
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: Naloxone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Technique to Anaesthetize the Lower Jaw
Status: UNKNOWN
Conditions: Inferior Alveolar Nerve Block
Interventions: PROCEDURE: A novel technique to block the inferior alveolar nerve block using Mepivecaine with Levonordefrin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety of GSK4024484 in Healthy Adult Participants
Status: RECRUITING
Conditions: Malaria, Falciparum
Interventions: DRUG: GSK4024484C|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Absorption, Distribution, Metabolism, and Excretion Study of [14C]Adavosertib
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: DRUG: [14C]Adavosertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Hemodynamic Effects of Two Modalities of Alveolar Recruitment Maneuvers in Major Abdominal Surgery Patients
Status: COMPLETED
Conditions: Cardiac Output|Decreased Cardiac Output|Hemodynamic Monitoring|Blood Pressure|Stroke Volume|Major Abdominal Surgery|Mechanical Ventilation|Hemodynamic Optimization
Interventions: PROCEDURE: alveolar recruitment maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Emotional Attention Bias Modification and Targeted Memory Reactivation in Alcohol Use Disorder
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder
Interventions: BEHAVIORAL: Emotional Attention Bias Modification and Targeted memory reactivation during REM sleep|BEHAVIORAL: Emotional Attention Bias Modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mirabegron for Treatment of Overactive Bladder Symptoms in Patients With Parkinson's Disease
Status: UNKNOWN
Conditions: Overactive Bladder|Parkinson Disease
Interventions: DRUG: Mirabegron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Albumin Administration in Cirrhotic Patients With Bacterial Infection and a Systemic Inflammatory Response Syndrome Unrelated to Spontaneous Bacterial Peritonitis
Status: TERMINATED
Conditions: Cirrhosis|Sepsis|Renal Failure
Interventions: DRUG: Human Albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of Voxelotor Administered Orally to Patients With Sickle Cell Disease (GBT_HOPE)
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: voxelotor|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open Versus Closed Kinetic Chain Exercises in Tibial Distraction Osteogenesis by Ilizarov's METHOD
Status: COMPLETED
Conditions: Limb Length Discrepancy|Bone Deformity
Interventions: OTHER: Open Kinetic Chain exercise|OTHER: Closed kinetic chain exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Sofosbuvir/Velpatasvir/Voxilaprevir Fixed-Dose Combination With or Without Ribavirin in Participants With Chronic Genotype 1 HCV Infection Previously Treated With a Direct Acting Antiviral Regimen
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: SOF/VEL/VOX|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT