pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety of Meibomian Gland Dysfunction and Dry Eye With an LED Blue Treatment Device
Status: WITHDRAWN
Conditions: Meibomian Gland Dysfunction
Interventions: DEVICE: 2-3 Joule LED blue light device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trabectedin Plus Radiotherapy in Soft Tissue Sarcoma Patients
Status: RECRUITING
Conditions: Liposarcoma, Myxoid|Sarcoma, Soft Tissue|Leiomyosarcoma|Liposarcoma|Pleomorphic Liposarcoma
Interventions: DRUG: Trabectedin|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics/Pharmacodynamics (PK/PD) of SHR-1603 in Subjects With Advanced Malignancies
Status: SUSPENDED
Conditions: Physiological Effects of Drugs|Neoplasms by Histologic Type|Lymphoma|Hematologic Neoplasms|Immunotherapy|Advanced Cancer
Interventions: DRUG: SHR-1603
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-escalation Study of BIBH 1 in Patients With Non-small Cell Lung Cancer Scheduled for Surgical Resection
Status: TERMINATED
Conditions: Lung Neoplasms
Interventions: DRUG: BIBH 1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential Dose-escalation Study to Assess the Safety, Tolerability and Pharmacokinetics of TB006 in Healthy Subjects
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: DRUG: TB006|OTHER: Sterile saline (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of a Novel Dose Adjustment Algorithm for Preventing Cytopenia-Related Delays During FOLFOX Chemotherapy
Status: COMPLETED
Conditions: Colorectal Cancer|Gastric Cancer|Esophageal Cancer|Ampullary Cancer|Small Bowel Cancer|Appendix Cancer
Interventions: OTHER: Algorithm for cytopenia-related delay and dose-reduction of mFOLFOX chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Center Based Early Intervention Program For Preschoolers With Developmental Disorders
Status: RECRUITING
Conditions: Development Disorder, Child|Developmental Disability|Development Delay|Autism Spectrum Disorder
Interventions: BEHAVIORAL: Center Based or In Home Early Intervention Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Types of Splints to Treat Dental Luxation Injuries
Status: COMPLETED
Conditions: Dental Trauma|Splints
Interventions: DEVICE: Splint retained by Bulk-fill flowable|DEVICE: Splint retained by Packable Composite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Supporting Parents of Young Children With Type 1 Diabetes in Closed-Loop System
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: BEHAVIORAL: Developmental & Technological Demands|BEHAVIORAL: Distress Reduction|BEHAVIORAL: Nutrition, Set Point, & C:I Ratio|BEHAVIORAL: Hypoglycemia management|BEHAVIORAL: Minimal Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioabsorbable Everolimus-Eluting Stents for Internal Pudendal Artery-Related Arteriogenic Erectile Dysfunction
Status: UNKNOWN
Conditions: Impotence, Arteriogenic
Interventions: DEVICE: Bioabsorbable everolimus-eluting stent deployment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Stimulation (tDCS) and Prism Adaptation in Spatial Neglect Rehabilitation
Status: UNKNOWN
Conditions: Spatial Neglect|Stroke|Cerebrovascular Disorders|Cerebral Infarction|Brain Diseases
Interventions: BEHAVIORAL: Prism Adaptation|DEVICE: Anodal tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Post Approval Study of the BARD® COVERA™ Arteriovenous (AV) Stent Graft
Status: ACTIVE_NOT_RECRUITING
Conditions: Arteriovenous Fistula
Interventions: DEVICE: Covera Vascular Covered Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computerized Cognitive Exercise Training Treatment for Adults With Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: OTHER: PACR (Plasticity-based, Adaptive, Computerized Cognitive Remediation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outcomes of an Anticoagulation Clinic in an University Hospital
Status: COMPLETED
Conditions: Cardiopathy|Chagas Disease|Hemorrhage|Thrombosis
Interventions: OTHER: Anticoagulation clinic|OTHER: Standard anticoagulation care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of BL-B01D1 in Combination With Osimertinib Mesylate Tablets in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: BL-B01D1|DRUG: Osimertinib Mesylate Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Emergency Call on Drowning
Status: NOT_YET_RECRUITING
Conditions: Drowning|Drowning; Anoxia|Drowning, Near|Drowning; Asphyxia|Drowning and Nonfatal Submersion|Drowning or Immersion of Unknown Intent|Drowning and Submersion, Undetermined Intent|Drowning and Submersion While in Bath-Tub|Drowning and Submersion While in Natural Water|Drowning and Submersion Due to Sailboat Sinking|Drowning and Submersion Due to Fall Off Ship|Drowning and Submersion While in Swimming-Pool
Interventions: OTHER: Drowning-related OHCA|OTHER: Drowning-related non-OHCA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Wakefulness Promoting Effect, Safety, Tolerability, and Pharmacokinetics (PK) of LML134 in Shift Work Disorder
Status: TERMINATED
Conditions: Circadian Rhythm Disorders
Interventions: DRUG: LML134|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Turoctocog Alfa in Haemophilia A Subjects
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A
Interventions: DRUG: turoctocog alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acceptability and Efficacy of the Zemedy App for Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: BEHAVIORAL: Zemedy App for Irritable Bowel Syndrome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Naturally Occurring Tea and Coffee-based Ingredients on Cognitive Performance
Status: COMPLETED
Conditions: Cognitive Change
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: AmaTea Guayusa Extract|DIETARY_SUPPLEMENT: Lion's Mane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Mental Imagery Training on Brain Plasticity and Motor Function in Individuals With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: PD neurofeedback|OTHER: PD control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Beta-blockade on Cardiopulmonary Exercise Testing
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm Patients Under Surveillance
Interventions: DRUG: Bisoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Central Venous Catheter Insertion Techniques
Status: COMPLETED
Conditions: Catheterization, Central Venous
Interventions: PROCEDURE: Anatomical Landmark technique|PROCEDURE: Ultrasound-guided pre location technique|PROCEDURE: Ultrasound-guided real-time technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Candesartan for Prevention of Cardiovascular Events After Cypher or Taxus Coronary Stenting (4C) Trial
Status: COMPLETED
Conditions: Hypertension|Coronary Artery Disease
Interventions: DRUG: Candesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: HepZero:Heparin Free Dialysis With Evodial
Status: COMPLETED
Conditions: Chronic Kidney Disease|Patients Requiring Heparin Free Dialysis Treatments
Interventions: OTHER: Heparin free dialysis technique|DEVICE: Evodial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Assessment of Ypeginterferon Alfa-2a in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Peginterferon alfa|DRUG: Peginterferon alfa 2a|DRUG: Peginterferon alfa-2a|DRUG: Peginterferon alfa-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: To Compare Free Gingival Grafts and Connective Tissue Grafts Around Implants With Lack of Keratinized Mucosa
Status: COMPLETED
Conditions: Dental Implants|Alveolar Mucosa
Interventions: PROCEDURE: Free Gingival Graft (FGG)|PROCEDURE: Connective Tissue Graft followed by Laser Gingivoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nordic-Baltic Coronary Revascularization Study in Patients With Proximal Left Descending Coronary Artery (LAD) Lesion.
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Coronary artery bypass grafting (CABG)|PROCEDURE: Percutaneous coronary intervention (PCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Controlled Intrathecal Analgesia With Bupivacaine for Chronic Low Back Pain
Status: COMPLETED
Conditions: Pain, Intractable|Breakthrough Pain|Chronic Pain
Interventions: DRUG: Bupivacaine|DRUG: Opioid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral Isotretinoin on The Level of SerumYKL40 in Acne Vulgaris Patients
Status: UNKNOWN
Conditions: Acne Vulgaris
Interventions: DRUG: Isotretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Modified Release Formulations of Danicopan in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Danicopan Modified Release Prototype 1|DRUG: Danicopan Modified Release Prototype 2|DRUG: Danicopan Modified Release Prototype 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Volatile Induction and Maintenance Anesthesia (VIMA) With Sevorane in Adult Patients Requiring General Anesthesia for Surgery in Terms of Quality of Anesthesia and Its Influence on the Cardiovascular System in Common Clinical Practice
Status: COMPLETED
Conditions: Anesthesia, General
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dermal Suturing Only Versus Layered Cutaneous Closure
Status: COMPLETED
Conditions: Wound Closure Techniques
Interventions: PROCEDURE: Dermal Suturing Only Wound Closure|PROCEDURE: Layered Cutaneous Wound Closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety of Noninvasive Electrical Stimulation of Acupuncture Points (NESAP) in Infants
Status: COMPLETED
Conditions: Pain
Interventions: DEVICE: EMPI Select Transcutaneous Electrical Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monoclonal Antibody RAV12 and Gemcitabine in Treating Patients With Metastatic Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: RAV12|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Statin and Angiotensin-converting Enzyme Inhibitor on Symptoms in Patients With SCAD
Status: TERMINATED
Conditions: Coronary Artery Dissection, Spontaneous
Interventions: DRUG: ramipril|DRUG: rosuvastatin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SGLT2 Inhibitors and Treatment of Heart Failure in Severe Renal Insufficiency
Status: TERMINATED
Conditions: Heart Failure With Reduced Ejection Fraction|Renal Insufficiency, Chronic
Interventions: DRUG: SGLT-2 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Propranolol as an Anxiolytic to Reduce the Use of Sedatives From Critically-ill Adults Receiving Mechanical Ventilation
Status: COMPLETED
Conditions: Mechanical Ventilation|Sedation|Critical Illness|COVID
Interventions: DRUG: Propranolol Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Intervention Study to Reduce the Use and Impact of Potentially Inappropriate Medications Among Older Adults
Status: TERMINATED
Conditions: Polypharmacy|Incontinence|Insomnia|Anxiety
Interventions: BEHAVIORAL: knowledge transfer tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Aralast NP With Antiviral Treatment and Standard of Care Versus Antiviral Treatment With Standard of Care in Hospitalized Patients With Pneumonia and COVID-19 Infection
Status: WITHDRAWN
Conditions: Covid19|Pneumonia, Viral
Interventions: DRUG: alpha1-proteinase inhibitor|DRUG: Antiviral Agents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Green-MED Diet Via the Gut-fat-brain Axis
Status: COMPLETED
Conditions: Abdominal Obesity Metabolic Syndrome
Interventions: OTHER: Physical activity|OTHER: Physical activity+ MED diet|OTHER: Physical activity+green MED diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetic, Pharmacodynamic and Tolerability Study of Otamixaban in Patients With Mild and Moderate Hepatic Impairment
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: otamixaban XRP0673
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Terbinafine HCl 250 mg Tablet Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Terbinafine HCl 250mg tablets|DRUG: Lamisil® 250 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Children Born From IVM-CAPA vs IVF or Natural Conception
Status: COMPLETED
Conditions: IVM|IVF
Interventions: OTHER: Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3|OTHER: Physical development and General Health|OTHER: Developmental Red flags
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Towards Personalized Medicine for OCD
Status: UNKNOWN
Conditions: Obsessive-Compulsive Disorder
Interventions: BEHAVIORAL: Cognitive behavioral therapy|BEHAVIORAL: Acceptance and commitment therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Enzastaurin With 5-Fluorouracil/Leucovorin (5-FU/LV) Plus Bevacizumab as Maintenance Regimen Following First Line Therapy for Metastatic Colon Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Enzastaurin|DRUG: Placebo|DRUG: Leucovorin (LV)|DRUG: 5-fluorouracil (5-FU)|DRUG: Bevacizumab (Bev)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Esmolol on the Hemodynamic Response to Orotracheal Extubation
Status: UNKNOWN
Conditions: Beta Blocker|Hemodynamic Instability
Interventions: DRUG: Prophylactic esmolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Restoration of Normative Postural Control
Status: RECRUITING
Conditions: Lower Limb Amputation Below Knee (Injury)
Interventions: DEVICE: direct EMG controlled prosthetic ankle|BEHAVIORAL: PT guided prosthetic training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Kinesiotaping and Pressure Garment on Women With Upper Extremity Lymphedema Following Mastectomy
Status: COMPLETED
Conditions: Breast Cancer Lymphedema
Interventions: OTHER: Kinesio Taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of HEC88473 Injection in Healthy Subjects, Obese Subjects and T2DM Subjects
Status: COMPLETED
Conditions: Healthy Subjects|Obesity|T2DM (Type 2 Diabetes Mellitus)
Interventions: DRUG: HEC88473 injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Carboplatin/Paclitaxel With or Without Investigational Drug (CS-7017) in Subjects With Metastatic Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Metastatic Non-small Cell Lung Cancer
Interventions: DRUG: CS7017 tablets|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Placebo Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Reinforcement Intervention for Increasing HIV Testing Among At-Risk Women
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV|HIV Testing|Women|Contingency Management
Interventions: BEHAVIORAL: Standard referral for HIV testing|BEHAVIORAL: Online risk reduction training|BEHAVIORAL: Reinforcement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZER-ALZ 6)
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer's Disease|Dementia|Brain Diseases|Central Nervous System Diseases|Nervous System Diseases|Neurodegenerative Diseases|Neurocognitive Disorders|Mental Disorders
Interventions: DRUG: Donanemab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of SDF With Different Post-treatment Protocols in Arresting Dental Caries
Status: COMPLETED
Conditions: Dental Caries
Interventions: DRUG: 38% SDF treatment|BEHAVIORAL: not to rinse for at least 30 minutes after SDF treatment|BEHAVIORAL: rinse mouth immediately after SDF treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Radical Prostatectomy in Chinese Men With Prostate Cancer and oligoMetastases to the Bone
Status: UNKNOWN
Conditions: Prostate Cancer Metastatic
Interventions: PROCEDURE: Radical prostatectomy plus standard care|DRUG: Standard of care for metastatic prostate cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mat Pilates Exercise Program in Patients With Axial Psoriatic Arthritis
Status: ENROLLING_BY_INVITATION
Conditions: Psoriatic Arthritis
Interventions: OTHER: Mat Pilates Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-Site Break Through Cancer Trial: Phase II Study Investigating Dual Inhibition of BCL2 and Menin in AML MRD Using the Combination of Venetoclax and Revumenib
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Venetoclax|DRUG: Revumenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical, Biochemical and Body Composition Analysis in Assessment of Steatosis in Non Alcoholic Fatty Liver Disease
Status: UNKNOWN
Conditions: Non-alcoholic Fatty Liver Disease NAFLD
Interventions: DIAGNOSTIC_TEST: Laboratory investigations, pelvi-abdominal US, fibroscan, and in body analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Trial to Evaluate Efficacy and Safety of Elagolix Tablets in Women With Moderate or Severe Endometriosis-associated Pain
Status: RECRUITING
Conditions: Endometriosis
Interventions: DRUG: Elagolix|DRUG: Elagolix placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose Study of AR882 in Healthy Adult Male Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Cohort 1: AR882 or placebo|DRUG: Cohort 2: AR882 or placebo|DRUG: Cohort 3: AR882 or placebo|DRUG: Cohort 4: AR882 or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Remimazolam With Flumazenil vs. Propofol During RFCA for Atrial Fibrillation
Status: COMPLETED
Conditions: Recovery
Interventions: DRUG: Remimazolam Besylate|DRUG: Flumazenil|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intervention With Lupin Kernel Fibre in Hypercholesterolemic Subjects
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: fabricated food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability of IMMUNA(IMM01-STEM) in Patients With Muscle Atrophy Related to Knee Osteoarthritis.
Status: RECRUITING
Conditions: Muscle Atrophy
Interventions: DRUG: IMM01-STEM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Antioxidant Supplementation of Culture Media on IVF Embryos
Status: COMPLETED
Conditions: Infertility, Female|Infertility, Male
Interventions: DRUG: EmbryORP®|DEVICE: O2 tension 20%|DEVICE: O2 tension 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Apple Polyphenols on Vascular Oxidative Stress and Endothelium Function Study (APP trial_2016)
Status: COMPLETED
Conditions: Endothelial Dysfunction
Interventions: DIETARY_SUPPLEMENT: Apple polyphenols|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Study of Effectiveness of rTMS on Rumination and Anhedonia in Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder|Bipolar Depression
Interventions: DEVICE: Bilateral rTMS|DEVICE: Sham rTMS|DEVICE: Unilateral rTMS (High frequency)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Visual Feedback Non-weight Bearing Exercise on the Elderly With Knee Osteoarthritis.
Status: UNKNOWN
Conditions: Osteoarthritis
Interventions: BEHAVIORAL: visual feedback with non-weight bearing exercise|BEHAVIORAL: elastic band exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Alfuzosin Hydrochloride to Promote Passage of Distal Ureteral Calculi
Status: COMPLETED
Conditions: Kidney Calculi|Ureteral Calculi|Colic
Interventions: OTHER: Alfuzosin Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: KL-A167 Injection in Recurrent or Metastatic Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma|Recurrent or Metastatic
Interventions: DRUG: KL-A167 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Volume of Bupivacaine in Adductor Canal Nerve Block
Status: UNKNOWN
Conditions: Anesthesia, Local
Interventions: DRUG: Levobupivacaine 5 mL|DRUG: Levobupivacaine 10 mL|DRUG: Levobupivacaine 15 mL|DRUG: Levobupivacaine 20 mL|DRUG: Levobupivacaine 25 mL|DRUG: Levobupivacaine 30 mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ex Vivo T-Cell Depletion of Mobilized Peripheral Blood Stem Cells Via CD34-Selection
Status: RECRUITING
Conditions: Stem Cell Transplant|Allogeneic
Interventions: DEVICE: CliniMACS CD34 Reagent system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of TS-022 in Adult Patients With Atopic Dermatitis With Pruritus (POC)
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: TS022|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Implementing an Integrated RMNCH Intervention by Community Health Workers in Achham and Dolakha: National Pilot
Status: UNKNOWN
Conditions: Reproductive, Maternal, Newborn, and Child Health|Integrated, Community-Health Systems
Interventions: OTHER: Community Health Worker|OTHER: Continuous Surveillance|OTHER: CB-Integrated Management of Newborn and Childhood Illness|OTHER: Group Antenatal and Postnatal Care|OTHER: Balanced Post-Partum Contraceptive Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Corticosteroid Pulse After Ablation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Solumedrol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Randomized Controlled Trial of Lower Abdominal Three-port Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Gallbladder Stone|Gallbladder Polyp
Interventions: PROCEDURE: laparoscopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Tofacitinib on Body Composition, Bone Mineral Density and Bone Marrow Adiposity in Patients With Rheumatoid Arthritis: the TOFAT Project
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tofacitinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Response to Endotracheal Tube Intubation at Different Time of Fentanyl Given During Induction
Status: COMPLETED
Conditions: Intubation, Intratracheal
Interventions: OTHER: Different given time
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy, Pharmacokinetics, Safety, and Tolerability of IGSC 20% in Subjects With Primary Immunodeficiency
Status: COMPLETED
Conditions: Primary Immunodeficiency
Interventions: BIOLOGICAL: IGSC 20%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of A Marketed Silicone Hydrogel Spherical Lens Used for Monovision Correction of Presbyopia
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: ACUVUE® OASYS with Transitions™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Technetium [99Tc] Methylene Diphosphonate in the Treatment of Psoriatic Arthritis
Status: COMPLETED
Conditions: Arthritis, Psoriatic
Interventions: DRUG: 99Tc methylene diphosphonate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rosiglitazone and Insulin in T1DM Adolescents
Status: COMPLETED
Conditions: Type 1 Diabetes|Puberty: >Tanner 2 Breast Development or Testis >4ml
Interventions: DRUG: Rosiglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label, Non-Comparative, Phase III Study of the Raf-Kinase Inhibitor BAY 43-9006 as a Subsequent to First-Line Therapy in Patients With Advanced Renal Cell Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Nexavar (Sorafenib, BAY43-9006)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MRG002 in the Treatment of Patients With HER2-mutated Unresectable/Metastatic Non-small Cell Lung Cancer (NSCLC).
Status: UNKNOWN
Conditions: Non-small- Cell Lung Cancer (NSCLC)
Interventions: DRUG: MRG002
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beneficial Effect of Insulin Glulisine by Lipoatrophy and Type 1 Diabetes (LAS)
Status: COMPLETED
Conditions: Type 1 Diabetes|Lipoatrophy
Interventions: DRUG: Apidra|DRUG: current insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Repetitive Transcranial Magnetic Stimulation on Resting State Brain Activity in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DEVICE: Active Repetitive Transcranial Magnetic Stimulation 1 Hz|DEVICE: Active Repetitive Transcranial Magnetic Stimulation 10 Hz|DEVICE: Active control site Repetitive Transcranial Magnetic Stimulation at 1Hz|DEVICE: Sham control site Repetitive Transcranial Magnetic Stimulation|DEVICE: Active control site Repetitive Transcranial Magnetic Stimulation at 10 Hz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Spine Surgery for Lenke 1 Adolescent Idiopathic Scoliosis
Status: RECRUITING
Conditions: Scoliosis|Spine Deformity|Adolescent Idiopathic Scoliosis
Interventions: PROCEDURE: single rod
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-Obesity Phentermine-Topiramate Extended Release Pharmacotherapy vs Placebo Among Patients Using a Wearable Activity Tracker
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Phentermine-Topiramate Extended Release|DRUG: Placebo|OTHER: Online support system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Safety and Effectiveness of a Neurological Thrombectomy Medical Device for Acute Ischemic Stroke
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DEVICE: neurological thrombectomy device is an investigational device.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effect of a Plant-based Ingredient on Generalized Hormonal Responses
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: plant-based ingredient|DIETARY_SUPPLEMENT: No plant-based ingredient
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Arterolane-PQP Versus DHA-PQP in Uncomplicated Falciparum Malaria in Eastern Myanmar
Status: WITHDRAWN
Conditions: Uncomplicated Falciparum Malaria|Artemisinin-resistant
Interventions: DRUG: Arterolane maleate-piperaquine phosphate (Synriam)|DRUG: Dihydroartemisinin-piperaquine phosphate (Duocotexin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment by a Bispecific CD3xCD20 Antibody for Relapse/Refractory Lymphomas After CAR T-cells Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma Refractory|Refractory Indolent Adult Non-Hodgkin Lymphoma|Refractory Transformed B-cell Non-Hodgkin Lymphoma|Refractory Primary Mediastinal Large B-Cell Cell Lymphoma|Refractory Mantle Cell Lymphoma
Interventions: DRUG: Obinutuzumab|DRUG: RO7082859
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-Reported Outcome and Safety Between Preoperative and Postmastectomy Radiotherapy in DIEP Flap Reconstruction
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: RADIATION: Preoperative radiotherapy|RADIATION: Postmastectomy radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of Mivebresib Tablet Alone or in Combination With Ruxolitinib Tablet or Navitoclax Tablet in Adult Participants With Myelofibrosis
Status: TERMINATED
Conditions: Myelofibrosis (MF)
Interventions: DRUG: Mivebresib|DRUG: Navitoclax|DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Preliminary Efficacy of Activated Recombinant Human Factor VII in Acute Intracerebral Haemorrhage
Status: COMPLETED
Conditions: Acquired Bleeding Disorder|Intracerebral Haemorrhage
Interventions: DRUG: activated recombinant human factor VII|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Rehabilitation and Education Program
Status: NOT_YET_RECRUITING
Conditions: Shoulder Arthritis|Patient Education|Prehabilitation|Shoulder Arthroplasty
Interventions: OTHER: Experimental: PREPS only|OTHER: Experimental: PREPS and therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Design Validation of Toric Contact Lenses in Senofilcon A With a Blue-Blocking Chromophore
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: Acuvue Oasys 1 Day for Astigmatism|DEVICE: TRA100/TRA200 series toric contact lens with HEVL-blocking chromophore
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Low-level Laser Acupuncture and Microcurrent Electrical Stimulation on Gag Reflex on Children
Status: RECRUITING
Conditions: Gagging
Interventions: DEVICE: low-level laser|BIOLOGICAL: microcurrent stimulation|DEVICE: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Braining- Aerobic Physical Activity as Add on Treatment in Bipolar Depression
Status: RECRUITING
Conditions: Bipolar Disorder|Bipolar Depression|Bipolar I Disorder|Bipolar II Disorder|Bipolar Affective Disorder; Remission in|Bipolar Affective Disorder, Currently Depressed, Moderate
Interventions: BEHAVIORAL: Aerobic Physical Exercise|BEHAVIORAL: Relaxing Physical Exercise|BEHAVIORAL: Information about physical exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of High Dose Radiation Therapy for Locally Advanced Pancreatic Cancer That Responded to Initial Chemotherapy Treatment
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Pancreatic Adenocarcinoma
Interventions: DRUG: Induction chemotherapy with modified FOLFIRINOX (FFX) or gemcitabine and nab-paclitaxel (GnP)|RADIATION: High dose radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of a Heterologous, Two-dose Ebola Vaccine in the DRC
Status: UNKNOWN
Conditions: Ebola Virus Disease
Interventions: BIOLOGICAL: Ad26.ZEBOV, MVA-BN-Filo vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of 8-weeks Systematic Corrective Exercise Program in Pronation Distortion Syndrome
Status: COMPLETED
Conditions: Pronation; Ankle|Distortion
Interventions: OTHER: Systematic corrective exercises and non-biomechanical functional exercises|OTHER: Non biomechanical functional exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Baby2Home (B2H) Mobile Health Application
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19 Pandemic|Health Knowledge, Attitudes, Practice|Perinatal Depression|Mental Health Wellness|Post Partum Depression
Interventions: OTHER: Baby2Home Mobile Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Acid-base Balance in Patients Undergoing Colonoscopy
Status: UNKNOWN
Conditions: Colonoscopy|Bowel Preparation
Interventions: DRUG: Lactated Ringer's solution|DRUG: Normal saline solution|DRUG: Acetate Ringer's solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Honey and Dextromethorphan on Nocturnal Cough and Sleep
Status: COMPLETED
Conditions: Cough|Respiratory Tract Infections
Interventions: DRUG: Dextromethorphan|DRUG: Buckwheat Honey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Subcutaneously Administered rAvPAL-PEG in Patients With Phenylketonuria for 24 Weeks
Status: COMPLETED
Conditions: Phenylketonuria
Interventions: BIOLOGICAL: BMN 165 (rAvPAL-PEG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 24-hour IOP-lowering Effect of 0.01% Bimatoprost
Status: COMPLETED
Conditions: Intraocular Pressure|Glaucoma|Ocular Hypertension
Interventions: DRUG: 0.01% bimatoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Abdominal Massage Applied After Surgery
Status: RECRUITING
Conditions: Reflux, Gastroesophageal|Abdominal Pain|Constipation|Diarrhea|Dyspepsia
Interventions: OTHER: Abdominal Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Deep Dry Needling on Muscle Tone in Healthy Subjects
Status: COMPLETED
Conditions: Muscle Tone Abnormalities
Interventions: DEVICE: Intervention-Dry Needling|DEVICE: Control-Dry Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Adaptive MRI-Guided SBRT for Unresectable Primary or Oligometastatic Central Thorax and Abdominal Malignancies
Status: COMPLETED
Conditions: Central Thorax Cancer|Liver Cancer|Non-Liver Abdominal Cancer
Interventions: RADIATION: MRI-guided stereotactive body radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Thoracic Outlet Syndrome (TOS) With Botox
Status: COMPLETED
Conditions: Thoracic Outlet Syndrome
Interventions: DRUG: Botulinum Toxin Type A injection (BOTOX)|DRUG: Botulinum Toxin Type A injection (BOTOX)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction Study With AGMB-129 and Midazolam in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: AGMB-129|DRUG: MDZ
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparative Effects of Rupatadine 10 mg, Hydroxyzine 50 mg and Placebo on Actual Driving Performance
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: Rupatadine|DRUG: Hydroxyzine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: ALBION "Assessment of the Best Loading Dose of Clopidogrel to Blunt Platelet Activation, Inflammation and Ongoing Necrosis"
Status: COMPLETED
Conditions: Ischemia
Interventions: DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial Evaluating the Effect of Pharmacological Ascorbate on Radiation Therapy for Pancreatic Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Neoplasm
Interventions: DRUG: Ascorbate|DRUG: Gemcitabine|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IPO-NEC Trial:Study on the Efficacy and Safety Using Sequential IP Therapy and Oct Lar in the Treatment of Advanced GI NEC
Status: COMPLETED
Conditions: Progression Free Survival of the Treatment
Interventions: DRUG: Irinotecan combined with cisplatin, octreotide lar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Explore the Advantages of Remimazolam Used on Gastroscopy
Status: UNKNOWN
Conditions: Induction of Anesthesia
Interventions: DRUG: Remimazolam combined propofol|DRUG: Remimazolam|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Triple Antiemetic Regimen for Chemoradiotherapy in Cervical Cancer or Nasopharyngeal Cancer
Status: COMPLETED
Conditions: Cervical Cancer|Nasopharyngeal Cancer|Chemotherapy-induced Nausea and Vomiting|Radiation-Induced Nausea and Vomiting|Antiemetic
Interventions: DRUG: Fosaprepitant|DRUG: tropisetron|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of High-Intensity Gait Training Using a Treadmill on Locomotion Recovery in Traumatic Brain Injury Patients
Status: TERMINATED
Conditions: Traumatic Brain Injury|Gait Disorders, Neurologic
Interventions: OTHER: HIGT - physical rehab|OTHER: Low intensity physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT