pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Chimeric Natural Killer Receptor-Universal T Cells for Refractory GVHD
Status: RECRUITING
Conditions: Graft vs Host Disease
Interventions: BIOLOGICAL: Chimeric Natural Killer Receptor Universal T-cells (CNK-UT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Sore Throat in Children: Comparison Between Two Supraglottic Devices, Ambu® AuraOnce™ Laryngeal Mask Airway (LMA) and I-Gel®.
Status: COMPLETED
Conditions: Laryngeal Masks|Pharyngitis|Minors|Anesthesia
Interventions: DEVICE: I-Gel|DEVICE: LMA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Impact of Thromboprophylaxis on Progression Free Survival of Patients With Advanced Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer|Thromboembolism
Interventions: DRUG: Innohep|DRUG: Chemotherapy: Gemcitabine + Nab-Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Metformin Therapy for Overweight Adolescents With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Metformin (glucophage)|OTHER: oral placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of How Single Rising Doses of SAR161271 Are Absorbed and Act in Patients With Type 1 Diabetes Mellitus (T1DM)
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: SAR161271|DRUG: Insulin glargine HOE901
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Examining the Effects of Patient Information Forms, Exercise Forms and Video Recordings
Status: RECRUITING
Conditions: Hand Injuries|Work-related Injury
Interventions: OTHER: hand rehabilitation with verbal explanation|OTHER: hand rehabilitation with patient information and exercise forms|OTHER: hand rehabilitation with video recording
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: intrathecaم Ketamine, Morphine and Both for Lower Abdominal Cancer Surgery Pain
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: intrathecal morphine|DRUG: intrathecal ketamine|DRUG: intrathecal morphine + ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Carcinoma, Non-small-Cell Lung
Interventions: DRUG: Amivantamab|DRUG: Lazertinib|DRUG: Carboplatin|DRUG: Pemetrexed|DRUG: Direct Oral Anticoagulant (DOAC)|DRUG: Low Molecular Weight Heparin (LMWH)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beetroot Juice NO Cold Study
Status: RECRUITING
Conditions: Respiratory Tract Infections|Cold Symptoms|Exhaled Nitric Oxide
Interventions: DIETARY_SUPPLEMENT: Beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of a PERsonalized CAse MAnagement Program for the Follow-up of Moderate and Severe aSTHma Patients on Exacerbations, Health Resource Use and Asthma Control: PERCASTHMA STUDY
Status: RECRUITING
Conditions: Asthma|Case Management|Telemedicine
Interventions: OTHER: Case management follow-up program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Medical Treatment Versus Surgery in Stricturing Small Bowel Crohn's Disease
Status: NOT_YET_RECRUITING
Conditions: Crohn Disease
Interventions: DRUG: Azathioprine + infliximab|PROCEDURE: Intestinal resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Outreach Collaborative Model for Early Identification and Treatment of Mental Disorder in Danish Workplaces
Status: COMPLETED
Conditions: Depression, Anxiety
Interventions: BEHAVIORAL: Standard Psychiatric Treatment|BEHAVIORAL: Preventive Psychological Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Metabolomic Profile in Dry Eye Syndrome Patients.
Status: UNKNOWN
Conditions: Dry Eye Syndromes|Cataract
Interventions: DRUG: Lubricant Eye Drops|DRUG: Preservative Free|DRUG: Preservative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Impact of a Family-Centered Empowerment Program on Self-Efficacy, Self-Esteem, Depression, Anxiety, Stress Level, and Care Skills in Parents of Children With Oncological Problems
Status: COMPLETED
Conditions: Pediatric Cancer
Interventions: BEHAVIORAL: Web-Based Education Based on Family-Centered Empowerment Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Longitudinal Study to Identify IBS Phenotypes Using Fecal Microbiota and Hydrogen Breath Testing
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Rifaximin 550 MG|OTHER: Low FODMAP Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects Of GW679769 (Casopitant) On The Pharmacokinetics Of Docetaxel In Subjects With Cancer
Status: COMPLETED
Conditions: Nausea and Vomiting, Chemotherapy-Induced
Interventions: DRUG: Docetaxel|DRUG: Casopitant/Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for Relief of Gag Reflex
Status: UNKNOWN
Conditions: Gagging During Transesophageal Echocardiography
Interventions: PROCEDURE: Acupuncture|PROCEDURE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Monotherapy Pazopanib in Subjects With Advanced Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer, Non-Small Cell
Interventions: DRUG: Pazopanib (GW786034)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-human Dose Escalation and Expansion Study With the SIRPα-directed Monoclonal Antibody BYON4228
Status: RECRUITING
Conditions: Lymphoma
Interventions: DRUG: BYON4228 + Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anesthetic Guidance of Depth of Anesthesia and Indirect Cardiac Output Monitoring in Thoracic Surgery
Status: COMPLETED
Conditions: Anesthesia|Hemodynamic Instability|Postoperative Respiratory Complication
Interventions: DEVICE: M-Entropy guidance of anesthesia depth|DEVICE: ProAQT in guiding goal-directed hemodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Group Intervention Program Based on Acceptance and Mindfulness on the Physical and Emotional Well-being of Overweight and Obese Individuals
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: BEHAVIORAL: Mind&Life|BEHAVIORAL: Standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Meal Composition and Timing Modification on Glucose Metabolism, Body Temperature and Sleep
Status: RECRUITING
Conditions: PreDiabetes|Type 2 Diabetes|Healthy
Interventions: BEHAVIORAL: Time Restrictive Eating- late|BEHAVIORAL: Time Restrictive Eating- early|BEHAVIORAL: Time Restrictive Eating- early with early caloric intake|OTHER: Macronutrient-controlled meals
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Virtual Seating Coach on Power Wheelchairs of Persons With Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: BEHAVIORAL: Virtual Seating Coach
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment With Allogeneic Adipose-derived Mesenchymal Stem Cells in Patients With Aqueous Deficient Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye|Kerato Conjunctivitis Sicca|Aqueous Tear Deficiency
Interventions: DRUG: Adipose tissue-derived mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Whether Etrolizumab is a Safe and Efficacious Treatment for Participants With Moderately to Severely Active Crohn's Disease
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DRUG: Etrolizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-antigen CMV-Modified Vaccinia Ankara Vaccine in Treating Pediatric Patients With Positive Cytomegalovirus Undergoing Donor Stem Cell Transplant
Status: RECRUITING
Conditions: Cytomegaloviral Infection|Hematopoietic Cell Transplant Recipient
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Multi-peptide CMV-Modified Vaccinia Ankara Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Reducing Stigma and Increasing Treatment Seeking Intentions Among Adolescents
Status: COMPLETED
Conditions: Stigma, Social|Mental Health Disorder|Adolescent Behavior|Depression
Interventions: BEHAVIORAL: Brief video intervention (Black Girl)|BEHAVIORAL: Brief video intervention (Black Boy)|BEHAVIORAL: Brief video intervention (Latinx Girl)|BEHAVIORAL: Brief video intervention (Latinx Boy)|BEHAVIORAL: Brief video intervention (White Girl)|BEHAVIORAL: Brief video intervention (White Boy)|BEHAVIORAL: Brief video intervention (Nonbinary or transgender)|BEHAVIORAL: Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mesalamine Pellet to Maintain Remission of Mild to Moderate Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Granulated mesalamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Comparison of the Sensitivity and Specificity of Acoustic Angiography to the Sensitivity and Specificity of Conventional Ultrasound
Status: COMPLETED
Conditions: Signs and Symptoms
Interventions: DEVICE: Acoustic Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Role of Immunoglobulin E (IgE) Bearing Cells in Chronic Idiopathic Urticaria (CIU)
Status: COMPLETED
Conditions: Urticaria Chronic
Interventions: DRUG: Omalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Bevacizumab in Combination With First- or Second-Line Therapy in Subjects With Treated Brain Metastases Due to Non-Squamous NSCLC (PASSPORT)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer|Brain Neoplasms
Interventions: DRUG: bevacizumab|DRUG: First-Line Chemotherapy Agents|DRUG: Second-Line Chemotherapy Agents
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACid Tranexamic or Terlipressin for Initial Emergency Treatment of Mild to seVere hEmoptysis: a Randomized Trial.
Status: RECRUITING
Conditions: Hemoptysis
Interventions: DRUG: Tranexamic Acid 500 MG|DRUG: Terlipressin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Human Insulin Inhalation Powder in Patients With Type 1 Diabetes Mellitus.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: insulin|DRUG: human insulin inhalation powder (HIIP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Pre-dive Ketone Food Products on Latency to CNS Oxygen Toxicity (Aim 2)
Status: ENROLLING_BY_INVITATION
Conditions: Oxygen Toxicity
Interventions: DIETARY_SUPPLEMENT: Ketogenic food products|DIETARY_SUPPLEMENT: Control: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Evaluating Efficacy and Safety of YM150 Compared to Enoxaparin in Subjects Undergoing Hip Replacement Surgery
Status: COMPLETED
Conditions: Venous Thromboembolism|Arthroplasty, Replacement, Hip
Interventions: DRUG: YM150|DRUG: enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Low vs Standard Local Anesthetics Boluses for Continuous Adductor Canal Block in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Arthropathy
Interventions: DRUG: Low bolus concentration and volume
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IDENTIFICATION OF PROGNOSTIC AND PREDICTIVE BIOMARKERS IN INFLAMMATORY BOWEL DISEASE
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases|Crohn Disease|Ulcerative Colitis
Interventions: PROCEDURE: endoscopic biopsy|PROCEDURE: samples of the oral cavity|PROCEDURE: Samples of the resected specimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Efficacy of BLEX 404 Oral Liquid Combined With Pemetrexed + Cisplatin Therapy
Status: NOT_YET_RECRUITING
Conditions: Nonsquamous Nonsmall Cell Neoplasm of Lung
Interventions: DRUG: BLEX 404
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Roux-en-Y vs. Roux-en-Y+ Pouch for D2 Total Gastrectomy
Status: UNKNOWN
Conditions: Gastric Cancer|Roux-en-y Anastomosis Site|Gastric Anastomosis (Site)|Quality of Life|Complication
Interventions: PROCEDURE: Roux-en-Y anastomosis|PROCEDURE: Roux-en-Y+Pouch anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conversion From Parenteral to Oral Methadone.
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Parenteral /oral methadone ratio 1:2|DRUG: Parenteral /oral methadone ratio 1:1.2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vitamin D Supplementation in the Armed Forces
Status: UNKNOWN
Conditions: Stress Fracture|Injury
Interventions: DIETARY_SUPPLEMENT: Supplementation Vitamin D3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of Vonoprazan Compared to Placebo for Relief of Heartburn in Participants With Symptomatic Non-Erosive Gastroesophageal Reflux Disease (NERD)
Status: COMPLETED
Conditions: Non-Erosive Gastro-Esophageal Reflux Disease|Heartburn
Interventions: DRUG: Vonoprazan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-inflammatory/Antioxidant Oral Nutrition Supplementation in COVID-19
Status: UNKNOWN
Conditions: COVID-19
Interventions: DIETARY_SUPPLEMENT: Oral supplement enriched in antioxidants|DIETARY_SUPPLEMENT: cellulose-containing placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Analysis of Primary and Metastatic Tumors in Patients With Renal Cell Carcinoma and Urothelial Carcinoma
Status: RECRUITING
Conditions: Renal Cell Carcinoma|Urothelial Carcinoma|Bladder Cancer|Ureter Cancer|Urethral Cancer
Interventions: BIOLOGICAL: Immune checkpoint inhibitor targeting PD1
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of End-tidal Carbon Dioxide (ETCO2) Measured by Transportable Capnometer (EMMATM) and the Arterial pCO2 in General Anesthesia
Status: COMPLETED
Conditions: End Tidal Carbon Dioxide of Patients Undergoing General Anesthesia
Interventions: DEVICE: End-tidal CO2(portable capnometer)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Shock Waves on Tooth Movement and Miniscrew Stability
Status: COMPLETED
Conditions: Mesial Movement of Teeth|Miniscrew Stability
Interventions: DEVICE: Extracorporeal shockwave therapy|DEVICE: ESWT placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-inferiority of Reduced-dose Rituximab in Rheumatoid Arthritis in Low Disease Activity and Remission
Status: TERMINATED
Conditions: Rheumatoid Arthritis|Remission
Interventions: DRUG: 500mg RTX Group|DRUG: 1000mg RTX Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Use of RHT-3201 in SCORAD Reduction in Young Patients With Atopic Dermatitis
Status: UNKNOWN
Conditions: Dermatitis, Atopic
Interventions: DIETARY_SUPPLEMENT: RHT-3201
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP3 Post Elimination Monitoring
Status: COMPLETED
Conditions: Human African Trypanosomiasis|Sleeping Sickness|Trypanosoma Brucei Gambiense; Infection|West African Sleeping Sickness|African Trypanosomiases|Trypanosomiasis; African, Due to Trypanosoma Brucei Gambiense, Gambiense
Interventions: DIAGNOSTIC_TEST: Rapid diagnostic test (RDT); Serological and molecular tests on DBS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rituximab for the Primary Treatment of Denovo Extensive Chronic Graft Versus Host Disease (GVHD)
Status: COMPLETED
Conditions: Chronic Graft-versus-host Disease
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation for Gait Recovery Following Stroke
Status: RECRUITING
Conditions: Stroke|Gait, Hemiplegic
Interventions: DEVICE: Anodal tDCS - Direct Current (DC)-stimulator (Soterix Medical, New York, NY, USA)|DEVICE: Anodal High-Definition (HD) tDCS - Direct Current (DC)-stimulator (Soterix Medical, New York, NY, USA)|DEVICE: Sham stimulation - Direct Current (DC)-stimulator (Soterix Medical, New York, NY, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiographic Evaluation of Adaptation of Universal Adhesives
Status: NOT_YET_RECRUITING
Conditions: Class II Dental Caries
Interventions: OTHER: Scotchbond universal adhesive plus|OTHER: Single bond Universal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Remediation in Youth at Risk of Serious Mental Illness
Status: TERMINATED
Conditions: Depression|Psychosis|Anxiety|Mental Illness
Interventions: BEHAVIORAL: Cognitive remediation treatment|BEHAVIORAL: Motivational Interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Topical Sinonasal Antibiotics
Status: UNKNOWN
Conditions: Chronic Rhinosinusitis (Diagnosis)|Antibiotic Side Effect
Interventions: DRUG: Oral versus topical antibioitics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Cognitive Functional Therapy on Patients With Non-specific Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: BEHAVIORAL: Individual Cognitive Functional Therapy|BEHAVIORAL: Group Exercise Classes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eplerenone Versus Spironolactone as Treatment of Ascites Due to Liver Cirrhosis; a Study of Efficacy and Side Effects
Status: WITHDRAWN
Conditions: Ascites|Cirrhosis
Interventions: DRUG: Eplerenone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficiency of Denosumab in Pediatric Subjects With Glucocorticoid-induced Osteoporosis
Status: COMPLETED
Conditions: Evaluate the Safety and Efficacy of Denosumab in Pediatric Subjects With|Glucocorticoid-induced Osteoporosis
Interventions: DRUG: Denosumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DC Migration Study for Newly-Diagnosed GBM
Status: COMPLETED
Conditions: Glioblastoma|Astrocytoma, Grade IV|Giant Cell Glioblastoma|Glioblastoma Multiforme
Interventions: BIOLOGICAL: Unpulsed DCs|BIOLOGICAL: Td|BIOLOGICAL: Human CMV pp65-LAMP mRNA-pulsed autologous DCs|BIOLOGICAL: 111In-labeled DCs|DRUG: Temozolomide|DRUG: Saline|DRUG: Basiliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Avatrombopag in Cancer Patients With Thrombocytopenia
Status: UNKNOWN
Conditions: Thrombocytopenia|Avatrombopag
Interventions: DRUG: Avatrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study To Establish Maximum Tolerated Dose (MTD) of Cyberknife in Patients With Un-Resectable Pancreas Cancer (TL002)
Status: TERMINATED
Conditions: Pancreas Cancer|Pancreatic Cancer|Adenocarcinoma of the Pancreas|Pancreas Adenocarcinoma|Pancreatic Adenocarcinoma
Interventions: DRUG: Gemcitabine|DRUG: nab-paclitaxel|RADIATION: CyberKnife
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Indacaterol 150 µg Versus Formoterol
Status: WITHDRAWN
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Indacaterol|DRUG: Formoterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of CNA3103 (LGR5-targeted, Autologous CAR-T Cells) Administered to Subjects With Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer Metastatic
Interventions: BIOLOGICAL: CNA3103: 5 x 10^7 cells|BIOLOGICAL: CNA3103: 1.5 x 10^8 cells|BIOLOGICAL: CNA3103: 4.5 x 10^8 cells|BIOLOGICAL: CNA3103: 1.5 x 10^9 cells|BIOLOGICAL: CNA3103: 2.5 x 10^7 cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Immune Response and the Safety Profile of a High-Dose Quadrivalent Influenza Vaccine (QIV-HD) Compared to a Standard-Dose Quadrivalent Influenza Vaccine (QIV-SD) in Europeans Adults 60 Years of Age and Older
Status: COMPLETED
Conditions: Influenza Immunization|Healthy Volunteers
Interventions: BIOLOGICAL: Standard-Dose influenza virus surface antigens (haemagglutinin and neuraminidase), Inactivated, Influenza Vaccine Quadrivalent, 2019-2020 Northern Hemisphere Strains (QIV-SD)|BIOLOGICAL: High-Dose Influenza Vaccine (split virion, inactivated), Quadrivalent (QIV-HD) 2019-2020 Northern Hemisphere formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: QG101-23-0 Capsules SAD and MAD Study in Healthy Subjects
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: QG101-23-0 capsules|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Safety and Efficacy of BCMA-GPRC5D CAR-T in Patients With Relapsed/Refractory Multiple Myeloma Who Received Three or More Lines of Therapy
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Fludarabine + Cyclophosphamide + BCMA-GPRC5D CAR-T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accuracy of Ultrasound in Identification of Cricothyroid Membrane: A Randomized Clinical Trial
Status: COMPLETED
Conditions: Difficult Breathing
Interventions: DEVICE: Ultrasound|OTHER: External Palpation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Extending Preservation and Assessment Time of Donor Lungs Using the Toronto EVLP System™ at a Dedicated EVLP Facility
Status: COMPLETED
Conditions: Lung Disease
Interventions: DEVICE: Toronto EVLP System™
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intravenous Ketorolac for Postoperative Pain in Percutaneous Nephrolithotomy
Status: COMPLETED
Conditions: Renal Calculus|Kidney Stones
Interventions: DRUG: Ketorolac|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Safety Study of ALK-001 in Healthy Volunteers
Status: COMPLETED
Conditions: Stargardt Disease|Age-related Macular Degeneration|Other Retinal Dystrophies
Interventions: DRUG: ALK-001 (No generic name)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of a Volunteer-based Lunch Program on Feelings of Loneliness in Elders
Status: COMPLETED
Conditions: Aged|Loneliness|Depression|Anxiety
Interventions: OTHER: Lunch with Medical Student|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Electromagnetic Stimulation Combined With Visceral Manipulation on Stress Urinary Incontinence In Postmenopausal Women
Status: COMPLETED
Conditions: Stress Urinary Incontinence|Postmenopausal Disorder
Interventions: DEVICE: Electromagnetic device|OTHER: visceral manipulation therapy|OTHER: General advice|OTHER: pelvic floor muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Neoadjuvant Therapy With BCD-217 (Nurulimab + Prolgolimab) in Patients With Resectable Stage III Skin Melanoma
Status: RECRUITING
Conditions: Melanoma Stage III|Melanoma (Skin)
Interventions: BIOLOGICAL: BCD-217|BIOLOGICAL: anti-PD1|PROCEDURE: Excision of the primary lesion|PROCEDURE: Regional lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Combination Therapy of Glucocorticoids and Bovine Colostrum in Treatment of Severe Alcoholic Hepatitis.
Status: COMPLETED
Conditions: Severe Alcoholic Hepatitis in 'Extremis'- Defined by mDF>54
Interventions: DIETARY_SUPPLEMENT: Bovine colostrum|DIETARY_SUPPLEMENT: Enteral Nutrition|OTHER: prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mulligan Mobilization Versus Instrument Assissted Soft Tissue Mobilization In Chronic Iateral Epicondylitis
Status: NOT_YET_RECRUITING
Conditions: Lateral Epicondylitis
Interventions: OTHER: mulligan mobilization|OTHER: instrumented assisted soft tissue mobilization|OTHER: conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasonographic Monitoring of Response to Infliximab in Patients With Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Ultrasonography|Infliximab
Interventions: BIOLOGICAL: infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Two Daily Disposable Lenses in a Population of Daily Disposable (DD) Lens Wearers
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Nelfilcon A contact lens|DEVICE: Narafilcon A contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study Assessing the Safety, Immunogenicity and Dose Response of VLA15, A New Vaccine Candidate Against Lyme Borreliosis
Status: COMPLETED
Conditions: Lyme Borreliosis, Nervous System
Interventions: BIOLOGICAL: VLA15 with Alum|BIOLOGICAL: VLA15 without Alum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Camrelizumab Combined With Apatinib Mesylate Tablets, Nab-paclitaxel and S-1 in the Treatment of Locally Advanced Gastric Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Gastric Cancer
Interventions: DRUG: Camrelizumab|DRUG: Apatinib Mesylate|DRUG: nab-paclitaxel|DRUG: S1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Electrical Acupoint Stimulation (TEAS) on Aged Patients Undergoing Lower Extremity Arthroplasty
Status: UNKNOWN
Conditions: Joint Replacement
Interventions: DEVICE: TEAS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of ORIC-101 in Combination With Enzalutamide
Status: TERMINATED
Conditions: Prostatic Neoplasms
Interventions: DRUG: ORIC-101|DRUG: enzalutamide 40 MG oral capsule [Xtandi]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contrast-medium Induced Nephrotoxicity in Patients Undergoing Coronary Angiography - Iodixanol Versus Iopromide
Status: COMPLETED
Conditions: Chronic Renal Insufficiency|Coronary Angiography
Interventions: DRUG: contrast agent (iopromide)|DRUG: contrast agent (iodixanol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial to Assess the Effectiveness of the GlucoWatch Biographer
Status: COMPLETED
Conditions: Diabetes Mellitus, Insulin-Dependent
Interventions: DEVICE: GlucoWatch® G2™ Biographer (GW2B)|DEVICE: Continuous Glucose Monitoring System (CGMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Preoperative Oral Carbohydrate on Hypotension After Anesthesia Induction in Elderly Patients With Joint Replacement
Status: NOT_YET_RECRUITING
Conditions: Carbohydrates|Aged|Post-induction Hypotension
Interventions: DIETARY_SUPPLEMENT: Carbohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PAI-1 Levels and Predicting Covid-19 Patients' Prognosis
Status: UNKNOWN
Conditions: Covid-19 Positivity Confirmed With PCR Positivity in the Nasopharyngeal Swab|Symptomatic Covid -19 Positive Patients Who Require Hospitalization|Patients Who Did Not Vaccinate Against Covid-19|Patients Among 20 to 90 Years of Age|Healthy Control Patients of the Same Age
Interventions: OTHER: Serum PAI-1 alpha analysis.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase I/II Study of Bexarotene in Combination With ZD1839 (IRESSA®) in the Treatment of Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Bexarotene|DRUG: Iressa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial in AML Secondary to MPNs Patients, Unfit for Intensive Chemotherapy, Investigating a Treatment Combination Including Decitabine and Venetoclax
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Venetoclax+Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Assessment of Resolvine for Treatment of Vitreomacular Attachment
Status: COMPLETED
Conditions: Vitreomacular Attachment|Vitreomacular Traction|Vitreomacular Adhesion
Interventions: DRUG: 36% Resolvine Intravitreal Injection|DRUG: 9% Resolvine Intravitreal Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Hand Arm Bimanual Intensive Technique Including Lower Extremity (HABIT-IL) on Hemiplegic Cerebral Palsy
Status: UNKNOWN
Conditions: Hemiplegic Cerebral Palsy
Interventions: OTHER: Hand Arm Bimanual Intensive Technique including Lower Extremity (HABIT-IL)|OTHER: Hand Arm bimanual intensive Technique (HABIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Leukotriene Inhibitor in Adult Patients With Moderate SARS-COV-2 Symptoms (COVID19)
Status: UNKNOWN
Conditions: Moderate Covid19
Interventions: DRUG: Leukotriene Receptor Antagonist|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ESTIMATION OF THE EFFECT OF MULTIPLE DOSE PF-06651600 ON THE PHARMACOKINETICS OF SINGLE DOSE MIDAZOLAM AND EFAVIRENZ
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: PF-06651600|DRUG: midazolam|DRUG: efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Vismodegib in Men With Metastatic CRPC With Accessible Metastatic Lesions for Tumor Biopsy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Vismodegib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sporozoite Challenge of Polyprotein Vaccinees
Status: COMPLETED
Conditions: Malaria, Falciparum|Malaria
Interventions: BIOLOGICAL: FP9-PP (FP9 polyprotein)|BIOLOGICAL: MVA-PP (Modified Virus Ankara polyprotein)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Jaktinib Versus Hydroxycarbamide in Subjects With Intermediate-2 or High-risk Myelofibrosis
Status: COMPLETED
Conditions: Myelofibrosis
Interventions: DRUG: Jaktinib|DRUG: Placebo to match Hydroxycarbamide|DRUG: Hydroxycarbamide Tablets|DRUG: Placebo to match Jaktinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fixation Free Sandwich Osteotomy With an Interpositional Inlay Graft in Compere to Conventional Sandwich Osteotomy
Status: NOT_YET_RECRUITING
Conditions: Vertical Ridge Deficiency|Atrophic Maxilla
Interventions: PROCEDURE: vertical augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Therapy of Ensartinib in Stage IB-IIIA ALK-positive Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Ensartinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palpation Versus Ultrasonography for Identifying the Cricothyroid Membrane in Case of a Laterally Deviated Larynx
Status: NOT_YET_RECRUITING
Conditions: Airway Management
Interventions: DIAGNOSTIC_TEST: identification of the cricothyroid membrane using Palpation|DIAGNOSTIC_TEST: Identification of the cricothyroid membrane using ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Psychoeducation Program for Parents of Children With DMD
Status: COMPLETED
Conditions: Psychoeducation|Parents|Psychological Wellness|Duchenne Muscular Dystrophy
Interventions: OTHER: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Feasibility Trial Testing the Bionic Pancreas With ZP4207
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Insulin Lispro|DRUG: ZP4207 (dasiglucagon)|DRUG: Glucagon|DEVICE: iPhone-based bionic pancreas|DEVICE: iLet-based bionic pancreas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Pharmacokinetics, Efficacy, Safety and Tolerability of CABENUVA
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV-1-infection|HIV Infections|HIV I Infection
Interventions: DRUG: CAB + RPV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TS-1 Plus Irinotecan and Cisplatin (IP) for Patients With Stage IIIB/IV Non Small Cell Lung Cancer (NSCLC)
Status: UNKNOWN
Conditions: Advanced Non-Small Cell Lung Cancer
Interventions: DRUG: Irinotecan|DRUG: Cisplatin|DRUG: TS-1 (S-1)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Laser and Balloon Angioplasty Versus Balloon Angioplasty to Treat Peripheral In-stent Restenosis
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: Turbo Elite Laser and Turbo Tandem Laser Guide Catheters|PROCEDURE: Balloon angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alpha-Lipoic Acid in Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer|Chemotherapeutic Toxicity
Interventions: DIETARY_SUPPLEMENT: Alpha-lipoic acid Plus Chemotherapy (doxorubicin (also known as Adriamycin) plus cyclophosphamide followed by taxol)|OTHER: Placebo Plus Chemotherapy (doxorubicin (also known as Adriamycin) plus cyclophosphamide followed by taxol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Auricular Point Compared to Body Point Acupuncture Theraphy on Tension-Type Headache
Status: COMPLETED
Conditions: Tension-Type Headache
Interventions: PROCEDURE: filiform needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pelvic Floor Muscle Training With and Without Biofeedback in Women With Stress Urinary Incontinence
Status: UNKNOWN
Conditions: Menopause|Urinary Incontinence, Stress
Interventions: OTHER: Pelvic floor muscle training|OTHER: Eletromyography Biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does CERC-501 Attenuate Stress-precipitated Smoking Lapse?
Status: COMPLETED
Conditions: Smoking
Interventions: DRUG: CERC-501|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose and Response of Intrathecal Hydromorphone in Patients Undergoing Cesarean Section at Virginia Commonwealth University Health System
Status: TERMINATED
Conditions: Cesarean Section|Obstetric Anesthesia
Interventions: DRUG: Intrathecal hydromorphone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Lignosus Rhinoceros TM02® as a Complementary Therapy for Uncontrolled Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Lignosus rhinoceros TM02®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Safety and Efficacy Study of CTAP101 Extended-release Capsules in Children With Secondary Hyperparathyroidism
Status: TERMINATED
Conditions: Chronic Kidney Disease stage3|Chronic Kidney Disease stage4|Vitamin d Deficiency|Secondary Hyperparathyroidism
Interventions: DRUG: CTAP101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pentamidine Plus Dapsone in the Prevention of Pneumocystis Carinii Pneumonia (PCP) in HIV-Infected Patients Who Cannot Take Trimethoprim or Sulfonamides
Status: COMPLETED
Conditions: Pneumonia, Pneumocystis Carinii|HIV Infections
Interventions: DRUG: Pentamidine isethionate|DRUG: Dapsone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Urgent-start Peritoneal Dialysis in ESRD Patients：A Multi-center Study
Status: COMPLETED
Conditions: End-Stage Renal Disease
Interventions: DEVICE: urgent-start peritoneal dialysis catheter|DEVICE: central venous catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Toddler Milk Containing L.Reuteri, Galacto-oligosaccharides and Palm-Oil Free Fat Blend
Status: COMPLETED
Conditions: Toddlers Bone Metabolism
Interventions: OTHER: Traditional cow's milk|OTHER: Experimental milk|OTHER: Habitual diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes
Status: RECRUITING
Conditions: Smoking Cessation|Electronic Cigarette Use|Cigarette Smoking
Interventions: DRUG: Regular Nicotine patch and lozenge dose|DRUG: Augmented Nicotine patch and lozenge dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Drug-drug Interactions Between DWN12088 and Nebivolol or Paroxetine in Healthy Volunteers
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: DWN12088|DRUG: Nebivolol|DRUG: Paroxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesia y After Uniportal Video-assisted Thoracoscopic Surgery
Status: RECRUITING
Conditions: Post-operative Pain, Acute|Post-operative Pain|Thoracic Diseases|Post-Op Complication
Interventions: PROCEDURE: Ultrasound-guided erector spinae plane block|PROCEDURE: surgical thoracoscopic intercostal nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Mastoid Bone Autograft for Dorsal Nasal Augmentation
Status: COMPLETED
Conditions: Nose Deformities, Acquired
Interventions: PROCEDURE: Rhinoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT