pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study Evaluating 13-valent Pneumococcal Conjugate Vaccine in Healthy Japanese Infants
Status: COMPLETED
Conditions: Vaccines, Pneumococcal Conjugate Vaccine
Interventions: BIOLOGICAL: 13vPnC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Application of 3D Printing Technique in Radical Gastrectomy With Leonardo da Vinci Robot
Status: UNKNOWN
Conditions: Stomach Neoplasms
Interventions: PROCEDURE: 3D printing model|PROCEDURE: non 3D printing model
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bortezomib and Gemcitabine in Treating Older Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Breast Cancer|Colorectal Cancer|Head and Neck Cancer|Kidney Cancer|Lung Cancer|Ovarian Cancer|Pancreatic Cancer|Prostate Cancer|Sarcoma
Interventions: DRUG: bortezomib|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SGLT-2 Inhibitors in Prevention of Post-procedural Renal and Cardiovascular Complications aFter PCI Among Patients With Diabetes Mellitus and Coronary Artery Disease: a Prospective, Randomized, Pilot Study (SAFE-PCI)
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Coronary Artery Disease|Acute Kidney Injury
Interventions: DRUG: empagliflozin 25 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Split Dose Polyethylene Glycol (PEG) + Clear Fluids Versus Split Dose PEG + Low-Residue Diet
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: OTHER: Split-dose PEG Based Lavage (2L + 2L) with Low-Fibre Lunch Dietary instructions|OTHER: Split-dose PEG Based Lavage (2L + 2L) with Standard Dietary Instructions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study to Assess Safety and Efficacy of Umbilical Cord-derived Mesenchymal Stromal Cells in Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: BIOLOGICAL: umbilical-cord mesenchymal stromal cells|DRUG: Hyaluronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Safety, Tolerability and Activity of a New Phosphate Binder (SBR759) in Patients With Chronic Kidney Disease on Hemodialysis
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: SBR759|DRUG: SBR759|DRUG: SBR759|DRUG: SBR759|DRUG: SBR759|DRUG: SBR759|DRUG: SBR759
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Control After Arthroscopic Shoulder Surgeries
Status: RECRUITING
Conditions: Post Operative Pain
Interventions: PROCEDURE: Ultrasound-guided Interscalene Block group|PROCEDURE: Combined Ultrasound guided shoulder anterior capsular block and suprascapular nerve block|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Sanaria's PfSPZ-CVac in Malian Adults
Status: COMPLETED
Conditions: Plasmodium Falciparum Infection
Interventions: DRUG: Artesunate|DRUG: Chloroquine|BIOLOGICAL: PfSPZ (NF54) Challenge|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Methylphenidate to Treat Gait Disorders And Attention Deficit In Parkinson's Disease (PARKGAIT-II)
Status: COMPLETED
Conditions: Parkinson's Disease|Gait Disorders, Neurologic|Dementia
Interventions: DRUG: methylphenidate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anatomical Feasibility of Multibranched Off-the-shelf Endografts for Thoracoabdominal and Para-renal Aortic Aneurysms (TAMBE Study)
Status: COMPLETED
Conditions: Thoracoabdominal Aneurysms and Para-renal Aortic Aneurysms
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency (SCID): Busulfan-based Conditioning With h-ATG, Radiation, and Sirolimus
Status: ENROLLING_BY_INVITATION
Conditions: Severe Combined Immune Deficiency (SCID)
Interventions: DRUG: Sirolimus|DRUG: Busulfan|DRUG: Horse -Anti-thymocyte|DRUG: G-CSF|RADIATION: Total Body Irradiation (TBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Sleep Quality of Patients Sedation With i.v. Dexmedetomidine or Midazolam Undergoing TURP
Status: COMPLETED
Conditions: Sleep Quality of Patients Undergoing TURP
Interventions: DRUG: dexmedetomidine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate Pregabalin In The Treatment Of Moderate To Severe Chronic Bone Pain Related To Metastatic Cancer
Status: TERMINATED
Conditions: Bone Neoplasms|Pain, Intractable|Cancer
Interventions: DRUG: Pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Mechanistic Study of Inhaled Nitric Oxide in COPD
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|Pulmonary Hypertension
Interventions: DEVICE: Nitric Oxide Generation and Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VRC 308: An Open-Label Phase I Study of the Safety and Immunogenicity of an Investigational H1 DNA Influenza Vaccine, VRC-FLUDNA057-00-VP, in Healthy Adults 18-70 Years Old
Status: COMPLETED
Conditions: Influenza A Virus, H1N1 Subtype|Novel Swine-Origin
Interventions: BIOLOGICAL: VRC-FLUDNA057-00-VP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Femoral Triangle Block With Popliteal Plexus Block Versus Femoral Triangle Block Versus Adductor Canal Block for TKA
Status: COMPLETED
Conditions: Pain, Acute|Opioid Use|Analgesia
Interventions: DRUG: Marcain 5 mg/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postanesthesia Cognitive Recovery and Neuropsychologic Complications
Status: UNKNOWN
Conditions: Anesthesia Recovery Period|Delirium, Dementia, Cognitive Disorders|Neurobehavioural Manifestation|Mental Competency
Interventions: DRUG: Hypnotics: propofol, sevoflurane, desflurane,desflurane,midazolam
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: OPT-IN: Osteopathic Plagiocephaly Treatment for Infants and Neonates
Status: RECRUITING
Conditions: Plagiocephaly, Nonsynostotic|Plagiocephaly, Positional|Plagiocephaly|Cranium; Deformity
Interventions: PROCEDURE: Osteopathic Manipulative Treatment|BEHAVIORAL: Standard of Care Repositioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cortical Excitability Sequential Changes in Response to Transcranial Magnetic Stimulation Post Stroke
Status: COMPLETED
Conditions: Stroke, Cardiovascular
Interventions: DEVICE: (LF-rTMS) group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block Analgesia for Lumbar Spine Fusion Surgery
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: Erector spinae plane block|DRUG: sham subcutaneous infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Trebananib in Treating Younger Patients With Relapsed or Refractory Solid Tumors, Including Central Nervous System Tumors
Status: COMPLETED
Conditions: Central Nervous System Neoplasm|Solid Neoplasm
Interventions: PROCEDURE: Dynamic Contrast-Enhanced Magnetic Resonance Imaging|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|BIOLOGICAL: Trebananib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vascular Aging and Lp299v Study
Status: RECRUITING
Conditions: Vascular Aging
Interventions: OTHER: Lactobacillus Plantarum 299v in fermented oat drink|OTHER: Heat-Killed Placebo control fermented drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Erythropoietin for Neonatal Encephalopathy in LMIC (EMBRACE Trial)
Status: RECRUITING
Conditions: Encephalopathy|Erythropoietin|Newborn Asphyxia
Interventions: DRUG: Erythropoietin|OTHER: Supportive neonatal intensive care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HABIT-ILE in Infants and Toddlers With Cerebral Palsy (Baby HABIT-ILE)
Status: UNKNOWN
Conditions: Cerebral Palsy
Interventions: BEHAVIORAL: Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE)|BEHAVIORAL: Regular care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Caspofungin After One Dose in Patients With Liver Failure
Status: COMPLETED
Conditions: Bacterial Infections and Mycoses|Liver Disease
Interventions: DRUG: Caspofungin 70 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Cyclophosphamide|DRUG: Docetaxel|DRUG: Gemcitabine|DRUG: Paclitaxel|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CMV-specific Cytotoxic T Lymphocytes Expressing CAR Targeting HER2 in Patients With GBM
Status: COMPLETED
Conditions: Glioblastoma Multiforme (GBM)
Interventions: BIOLOGICAL: HER.CAR CMV-specific CTLs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Platform of Patient Derived Xenografts (PDX) and 2D/3D Cell Cultures of Soft Tissue Sarcomas (STS)
Status: RECRUITING
Conditions: Soft Tissue Sarcoma|Xenograft Model|2D/3D Cell Cultures
Interventions: OTHER: tumor biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Differential Effects of Oral and Intranasal Oxytocin on Attention Control
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxytocin|DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Positively Smoke Free on the Web (PSFW) for Smokers Living With HIV
Status: COMPLETED
Conditions: Tobacco Use Cessation|Tobacco Cessation|Tobacco Use Disorder|Tobacco Dependence|Tobacco-Use Disorder|Virus, Human Immunodeficiency
Interventions: BEHAVIORAL: Web-Based Tailored Smoking Cessation Intervention|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inovium Ovarian Rejuvenation Trials
Status: COMPLETED
Conditions: Perimenopausal Disorder|Menopause|Menopause, Premature|Menopause Related Conditions|Menopause Premature Symptomatic|Menopause Premature Asymptomatic|Premature Ovarian Failure|Premature Ovarian Failure, Familial|Premature Ovarian Failure 2A|Premature Ovarian Failure 3|Premature Ovarian Failure 4|Premature Ovarian Failure 1|Premature Ovarian Failure 5|Premature Ovarian Failure 6|Premature Ovarian Failure 7|Premature Ovarian Failure 9|Premature Ovarian Failure 8|Infertility|Infertility, Female|Infertility Unexplained
Interventions: OTHER: Autologous PRP injection into human ovarian tissue
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2a Study on Intravenous Infusion of Autologous Osteoblastic Cells in Severe Osteoporosis
Status: COMPLETED
Conditions: Severe Osteoporosis
Interventions: DRUG: PREOB® Intravenous Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Pharmacokinetics of RO7079901 and Meropenem in Participants With a Complicated Urinary Tract Infection
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: DRUG: RO7079901|DRUG: Meropenem
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HAIC Plus Lenvatinib vs HAIC Plus Sorafenib for Advanced HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Lenvatinib|DRUG: Sorafenib|PROCEDURE: Hepatic arterial infusion chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dolutegravir-Lamivudine for naïve HIV-Infected Patients With ≤200 CD4/mm3
Status: COMPLETED
Conditions: HIV-1-infection
Interventions: DRUG: Intervention Arm: dolutegravir/lamivudine|DRUG: Comparator ARM: TDF/XTC plus Dolutegravir (XTC stand for lamivudine OR emtricitabine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic NK Cell ("SMT-NK") in Combination With Pembrolizumab in Advanced Biliary Tract Cancer
Status: COMPLETED
Conditions: Biliary Tract Cancer
Interventions: BIOLOGICAL: 'SMT-NK' Inj (allogeneic Natural Killer cell)|DRUG: Pembrolizumab Injection [Keytruda]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Re-operation Rates of Concorde Bullet Device Versus Conduit Titanium Interbody Graft for Lumbar Fusion
Status: COMPLETED
Conditions: Degenerative Spondylolisthesis|Lumbar Spondylosis|Lumbar Spondylolisthesis
Interventions: DEVICE: Conduit Titanium Interbody Graft|DEVICE: Concorde Bullet Device
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Validation of Clinical Efficacy and Development of New Diagnostic Algorithm of Probe-based Confocal Laser Endomicroscopy in Patients With Lower Gastrointestinal Disorder
Status: UNKNOWN
Conditions: Lower Gastrointestinal Disorders
Interventions: PROCEDURE: probe-based confocal laser endomicroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Look at How Insulin NNC0471-0119 Works in the Body in People With Type 1 Diabetes When Injected by Insulin Pump
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: NNC0471-0119 A|DRUG: NNC0471-0119 B|DRUG: NNC0471-0119 D|DRUG: Faster aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Simvastatin Nasal Rinses for the Treatment of COVID-19 Mediated Dysomsia
Status: WITHDRAWN
Conditions: Olfactory Disorder|COVID-19
Interventions: DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is it Safe to do Endometrial Injury in the Same ICSI Cycle: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: Endometrial injury
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of Calcium Carbonate and Ferrous Fumarate on Pharmacokinetics of Dolutegravir in Healthy Adult Subjects
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: Dolutegravir 50 mg|DRUG: Calcium Carbonate 1200 mg|DRUG: Ferrous Fumarate 324 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Soft Tissue Response to Titanium Healing Abutments Treated by Erbium: YAG Laser or Plasma Spray
Status: COMPLETED
Conditions: Peri-implant Mucositis
Interventions: DEVICE: Er: YAG laser|DEVICE: plasma spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Scapular and Cervical Neuromuscular Control Deficits in Musicians With and Without Playing Injuries.
Status: COMPLETED
Conditions: Playing Related Musculoskeletal Disorders
Interventions: OTHER: (1) cranio-cervical flexion test;|OTHER: (2) scapular dyskinesis test|OTHER: (3) deep neck flexor endurance test.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Windows Trial of INsulin-like Growth Factor Neutralising Antibody Xentuzumab in MEN Scheduled for Radical Prostatectomy (WINGMEN)
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Xentuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Donepezil and Selegiline Effects on Cocaine-Reinforced Behavior
Status: COMPLETED
Conditions: Cocaine Use Disorders
Interventions: DRUG: High-dose donepezil|DRUG: Low-dose donepezil|DRUG: Selegiline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Using a Real-Time Risk Prediction Model to Predict Pediatric Venous Thromboembolism (VTE) Events
Status: COMPLETED
Conditions: Venous Thromboembolism|Pediatrics|Deep Vein Thrombosis|Pulmonary Embolism
Interventions: OTHER: Hematology Review
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Changes in Pulpal Blood Flow of Teeth During Leveling and Alignment Stages of Orthodontic Treatment Using Clear Aligners
Status: COMPLETED
Conditions: Alignment
Interventions: OTHER: Orthodontic Alignment|OTHER: Orthodontic Alignment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Femoral Bone Metastases
Status: RECRUITING
Conditions: Cancer|Metastatic Malignant Neoplasm to Femur|Risk of Fracture
Interventions: PROCEDURE: Surgery Alone|OTHER: Combined Surgery and Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Analysis of Tumor Tissue and Lymph Nodes Surgically Removed From Patients With Cancers of the Head and Neck
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: GENETIC: DNA stability analysis|GENETIC: microsatellite instability analysis|GENETIC: mutation analysis|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Gemcitabine, Docetaxel, and Hydroxychloroquine in Treating Participants With Recurrent or Refractory Osteosarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Osteosarcoma|Refractory Osteosarcoma
Interventions: DRUG: Docetaxel|DRUG: Gemcitabine|DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Study of Safety and Tolerability of Alvelestat
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Alvelestat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Advanced Immunoclinical Phenotyping of Rejection in Lung Transplant
Status: RECRUITING
Conditions: Chronic Rejection of Lung Transplant
Interventions: DIAGNOSTIC_TEST: Lung transplant recipient without MRI imaging|DRUG: Lung transplant recipient with MRI imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: FAME II - Fractional Flow Reserve (FFR) Guided Percutaneous Coronary Intervention (PCI) Plus Optimal Medical Treatment (OMT) Verses OMT
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: OTHER: Stenting plus OMT|OTHER: OMT|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Subthalamic Nucleus Stimulation Effect on Gait Symmetry and Freezing of Gait
Status: TERMINATED
Conditions: Parkinson Disease
Interventions: PROCEDURE: Unilateral reduction of stimulation|PROCEDURE: Chronic Subthalamic nucleus stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D in Ventilated ICU Patients
Status: COMPLETED
Conditions: Respiratory Failure
Interventions: DRUG: Enteral Vitamin D3 50,000 IU|DRUG: Enteral Vitamin D3 100,000IU|OTHER: Inactive substance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immobilization Versus Observation in Children With Toddler's Fractures: a Prospective Randomized Controlled Trial
Status: COMPLETED
Conditions: Tibial Fractures
Interventions: PROCEDURE: Short leg cast|PROCEDURE: No Immobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Uterine Artery Color Doppler Parameters After Bilateral Uterine Artery Ligation
Status: COMPLETED
Conditions: Postpartum Hemorrhage|Ligation|Color Doppler|Uterine Artery
Interventions: PROCEDURE: Control group|PROCEDURE: BUAL group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: AK104 and Low-dose Radiation in Recurrent/Metastatic HNSCC After Failure of First-line Systemic Therapy
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Cadonilimab|RADIATION: Low-dose radiotherapy|RADIATION: SBRT|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of DAPTACEL® as 5th Dose in Children 4 to 6 Years Old After 4 Doses of Pentacel™ or DAPTACEL®
Status: COMPLETED
Conditions: Diphtheria|Tetanus|Pertussis
Interventions: BIOLOGICAL: DAPTACEL®: DTaP|BIOLOGICAL: DAPTACEL®: DTaP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: What is the Effective Pulmonary Physiotherapy Method in Critically Care Patients?
Status: COMPLETED
Conditions: Atelectasis
Interventions: DEVICE: routine pulmonary rehabilitation|DEVICE: chest wall vibration technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study Comparing a 13-valent Pneumococcal Conjugate Vaccine With 23-valent Pneumococcal Polysaccharide Vaccine in Adults
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: 13-valent pneumococcal conjugate vaccine (13vPnC)|BIOLOGICAL: 23-valent Pneumococcal Polysaccharide Vaccine (23vPS)|BIOLOGICAL: 13-valent pneumococcal conjugate vaccine (13vPnC)|BIOLOGICAL: 13-valent pneumococcal conjugate vaccine (13vPnC)|BIOLOGICAL: 13-valent pneumococcal conjugate vaccine (13vPnC)|BIOLOGICAL: 23-valent Pneumococcal Polysaccharide Vaccine (23vPS)|BIOLOGICAL: 13-valent pneumococcal conjugate vaccine (13vPnC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intravenous Acetaminophen and Morphine Versus Intravenous Morphine Alone for Acute Pain in the Emergency Department
Status: UNKNOWN
Conditions: Pain Management
Interventions: DRUG: placebo of acetaminophen IV|DRUG: acetaminophen IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tailored Tobacco Quitline for Rural Veterans
Status: COMPLETED
Conditions: Cigarette Smoking
Interventions: DRUG: Nicotine replacement therapy - transdermal nicotine patch|BEHAVIORAL: Tailored behavioral intervention|BEHAVIORAL: Tobacco quit line referral|DRUG: Nicotine replacement therapy - nicotine gum|DRUG: Nicotine replacement therapy - nicotine lozenge|DRUG: Bupropion Sustained Release|DRUG: Varenicline|DRUG: Combination pharmacotherapy - transdermal nicotine patch + nicotine gum|DRUG: Combination pharmacotherapy - transdermal nicotine patch + nicotine lozenge|DRUG: Combination pharmacotherapy - transdermal nicotine patch + bupropion|BEHAVIORAL: Alcohol use risk reduction|BEHAVIORAL: Behavioral activation for the treatment of depression|BEHAVIORAL: Behavioral management of post-cessation weight gain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on PEG-rhG-CSF in Mobilizing Autologous Hematopoietic Stem Cells
Status: RECRUITING
Conditions: Lymphoma
Interventions: DRUG: PEG-rhG-CSF|DRUG: RhG-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti Inflammatory Lipid Mediators in Asthma Lipid Anti-Inflammtory Mediators in Asthma
Status: RECRUITING
Conditions: Asthma|Obesity
Interventions: DRUG: CXA-10|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Investigate Two 3-dose Schedules Of A Clostridium Difficile Vaccine In Healthy Adults Aged 65 to 85 Years
Status: COMPLETED
Conditions: Clostridium Difficile Associated Disease
Interventions: BIOLOGICAL: Clostridium difficile Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Epidermal Growth Factor Receptor Inhibition for Keratinopathies
Status: NOT_YET_RECRUITING
Conditions: Epidermolytic Ichthyosis|Palmoplantar Keratoderma|Pachyonychia Congenita
Interventions: DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Ketone Bodies and Epigallocatechin Gallate in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DIETARY_SUPPLEMENT: Coconut oil and epigallocatechin gallate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Perception of Insertion Pain With Accu-Chek FlexLink and FlexLink Plus Insulin Pump Devices Under Real Life Conditions in Diabetic Patients.
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2, Diabetes Mellitus Type 1
Interventions: DEVICE: Accu-Chek FlexLink|DEVICE: Accu-Chek FlexLink Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clazosentan in Aneurysmal Subarachnoid Hemorrhage
Status: TERMINATED
Conditions: Aneurysmal Subarachnoid Hemorrhage
Interventions: DRUG: Clazosentan 5 m/h|DRUG: Clazosentan 15 mg/h|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Live Birth Rate in Natural Cycle Single Euploid FET Versus Without Luteal Phase Support
Status: RECRUITING
Conditions: Pregnancy Related|Infertility, Female
Interventions: DIAGNOSTIC_TEST: Transvaginal ultrasound|DIAGNOSTIC_TEST: Serial serum LH, E2, P4|DRUG: Progesterone 100 Mg Vaginal Insert|DIAGNOSTIC_TEST: Serum P4 day of ET - Control Group|DIAGNOSTIC_TEST: Serum P4 day of ET - Study Group|PROCEDURE: Embryo transfer|DIAGNOSTIC_TEST: Serum hCG 10 days after ET|DIAGNOSTIC_TEST: Serum P4 10 days after ET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Quantifying Oxygen Utilization of Tumors Using Oxygen-Enhanced Molecular MRI
Status: TERMINATED
Conditions: Malignant Brain Neoplasm
Interventions: PROCEDURE: Arterial Spin Labeling Magnetic Resonance Imaging|PROCEDURE: pH-Weighted amine CEST|PROCEDURE: Oxygen-weighted SAGE-EPI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Single and Multiple Ascending Dose Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD2389 in Healthy Participants
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: AZD2389|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sisonke (Together): OPEN LABEL TRIAL COVID-19
Status: COMPLETED
Conditions: SARS (Severe Acute Respiratory Syndrome)
Interventions: BIOLOGICAL: To monitor the effectiveness of the single dose Ad26.COV2.S COVID-19 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Chemoradiotherapy With Targeted Immunotherapy in Pediatric Lymphoma
Status: RECRUITING
Conditions: Non-hodgkin Lymphoma|Hodgkin Lymphoma
Interventions: DRUG: DOC Group B|DRUG: Pv-COMRAD 1 and 2 Group B|DRUG: Pv-R-CYM 1 and 2 Group B|DRUG: DOC Group C|DRUG: MAD CPR 1 and 2|DRUG: Pv-R CYVE 1 and 2|DRUG: Pv-R CYVE-MTX 1 and 2|DRUG: MAD CP|DRUG: Pv-Cytarabine/etoposide|DRUG: AD CP|DRUG: Bv-AVD-R 1 and 2: COHORT IIa|DRUG: Bv-NVD-R, Cycle 1-2|DRUG: Bv-NVD-R, Cycle 1-4 SER|DRUG: Bv-AVD-R|DRUG: Bv-NVD-R, Cycle 1-4 RER|DRUG: Bv-NAVD-R, Cycle 1-2|RADIATION: Involved Site Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: R-ICE Versus R-DHAP in Patients Aged 18-65 With Relapse Diffuse Large B-cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Large-Cell, Diffuse
Interventions: DRUG: Rituximab|DRUG: Etoposide|DRUG: Carboplatine|DRUG: Ifosfamide + Mesna|DRUG: Cisplatine|DRUG: Cytosine Arabinoside|DRUG: Dexamethasone|PROCEDURE: Autologous Stem Cell Transplantation|DRUG: BCNU|DRUG: Etoposide|DRUG: Cytarabine|DRUG: Melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Isoflavone in Prostate-specific Antigen Recurrent Prostate Cancer
Status: COMPLETED
Conditions: Biochemical Recurrent Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: Isoflavone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotics in the Prevention of Antibiotic Induced Diarrhea and Clostridium Difficile Associated Diarrhea.
Status: TERMINATED
Conditions: Diarrhea, Clostridium Difficile
Interventions: DIETARY_SUPPLEMENT: Probiolife by Green Made (Pharma M)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Insulin Glargine and Lixisenatide on the Brain
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: IGlarLixi|DRUG: Insulin Glargine 100 UNT/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Enhancement by Poly-ICLC During HIV-1 Infection
Status: COMPLETED
Conditions: HIV-1 Infected Adults With Chronic HIV-1 Infection
Interventions: DRUG: Arm A: Poly-ICLC|DRUG: Arm B: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Tunable-tension Transobturator Tape vs Standard Transobturator Midurethral Tape for Stress Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: Tunable-tension transobturator tape, Urosling-T (Lintex, LLC)|DEVICE: Transobturator mid-urethral tape, Urosling (Lintex, LLC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SBRT+TACE+Sorafenib Vs Sorafenib in the Treatment of uHCC With PVTT
Status: RECRUITING
Conditions: Unresectable Hepatocellular Carcinoma|Portal Vein Thrombosis
Interventions: RADIATION: SBRT+TACE+Sorafenib|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Capecitabine for the Treatment of Unresectable/ Metastatic or Advanced Hepatocellular Carcinoma(HCC)
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Capecitabine in HCC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Graston Technique Versus MET on Improving Hamstring Flexibility and ADLS in Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DIAGNOSTIC_TEST: Graston technique|DIAGNOSTIC_TEST: muscle energy technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rescuing the Ruminating Brain: Identifying Biomarkers of Rumination and Mindfulness Through Concurrent EEG and Functional Magnetic Resonance Imaging (fMRI) Studies of Schizophrenia and Depression
Status: WITHDRAWN
Conditions: Schizophrenia|Depressive Disorder, Major
Interventions: OTHER: Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vortioxetine for Posttraumatic Stress Disorder
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: DRUG: Placebo|DRUG: Vortioxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Clinical Trial of CAD/CAM and Conventionally Fabricated Singl Implant Abutments.
Status: UNKNOWN
Conditions: Missing Teeth|Teeth Replacemnt by Single Dental Implant|Zirconia Abutment|Titanium Abutment
Interventions: DEVICE: dental implants - zirconia abutmetns - prefabricated abutments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Fluoroscopic vs Ultrasound Guided Sacroiliac (SI) Joint Injection
Status: COMPLETED
Conditions: Pain, Chronic
Interventions: PROCEDURE: Ultrasound-guided sacroiliac joint injection|PROCEDURE: Flouroscopy-guided sacroiliac joint injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topiramate vs. Placebo in Preventing Weight Gain in Bipolar Disorder Treated With Olanzapine
Status: COMPLETED
Conditions: Bipolar Disorder|Weight Gain
Interventions: DRUG: Topiramate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Maximum Tolerated Dose of an Investigational Drug in Subjects With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: DSP-1349M|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating HLA-A2 Positive Patients With Melanoma
Status: COMPLETED
Conditions: Recurrent Melanoma|Stage IA Melanoma|Stage IB Melanoma|Stage IIA Melanoma|Stage IIB Melanoma|Stage IIC Melanoma|Stage IIIA Melanoma|Stage IIIB Melanoma|Stage IIIC Melanoma
Interventions: BIOLOGICAL: HPV 16 E7:12-20|BIOLOGICAL: gp100:209-217(210M)|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total-Body Irradiation, Busulfan, and Interferon Alfa Followed by Peripheral Stem Cell or Bone Marrow Transplantation in Treating Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: recombinant interferon alfa|DRUG: busulfan|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Phase III Long Term Study of K-877 Extended Release Tablet
Status: COMPLETED
Conditions: Dyslipidemias
Interventions: DRUG: K-877 ER 0.2 mg/day morning administration (once daily)|DRUG: K-877 ER 0.2 mg/day evening administration (once daily)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficiency of Placental Drug Melsmon® in Correction of Climacteric Symptoms in Premenopausal Women
Status: COMPLETED
Conditions: Climacteric Syndrome
Interventions: DRUG: Melsmon|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of DLBS2411 in the Management of GERD
Status: TERMINATED
Conditions: Gastroesophageal Reflux Disease (GERD)
Interventions: DRUG: Omeprazole|DRUG: DLBS2411|DRUG: Placebo capsule of Omeprazole|DRUG: Placebo caplet of DLBS2411
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II MEDI4736 in Combination With Chemotherapy for First-Line Treatment of Unresectable Mesothelioma
Status: COMPLETED
Conditions: Mesothelioma|Pleural Mesothelioma
Interventions: DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Find Out if a Combination of 3 Medicines for the Treatment of Malaria Works as Well and is as Safe and Tolerable as Combinations of 2 Medicines
Status: NOT_YET_RECRUITING
Conditions: Uncomplicated Plasmodium Falciparum Malaria
Interventions: DRUG: Artemether-Lumefantrine-Amodiaquine (ALAQ)|DRUG: Artemether-Lumefantrine (AL)|DRUG: Artesunate-Amodiaquine (ASAQ)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2, Multicenter Open-Label Extension (OLE) Study With ABT-122 in Active Psoriatic Arthritis Subjects Who Have Completed a Preceding Study M14-197
Status: TERMINATED
Conditions: Psoriatic Arthritis
Interventions: DRUG: ABT-122
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intrathecal Magnesium Sulfate Versus Intravenous Magnesium Sulfate on Postoperative Pain After Abdominal Hysterectomy
Status: NOT_YET_RECRUITING
Conditions: Abdominal Hysterectomy
Interventions: DRUG: Magnesium sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: PK/PD Biosimilarity Study of Gan & Lee Insulin Glargine Injection vs.US & EU Lantus® in Type 1 Diabetes Mellitus Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Gan & Lee Insulin Glargine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide and Rituximab in Treating Patients With Previously Untreated Stage II, Stage III, or Stage IV Follicular Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Ann Arbor Stage II Grade 1 Contiguous Follicular Lymphoma|Ann Arbor Stage II Grade 1 Non-Contiguous Follicular Lymphoma|Ann Arbor Stage II Grade 2 Contiguous Follicular Lymphoma|Ann Arbor Stage II Grade 2 Non-Contiguous Follicular Lymphoma|Ann Arbor Stage II Grade 3 Contiguous Follicular Lymphoma|Ann Arbor Stage II Grade 3 Non-Contiguous Follicular Lymphoma|Ann Arbor Stage III Grade 1 Follicular Lymphoma|Ann Arbor Stage III Grade 2 Follicular Lymphoma|Ann Arbor Stage III Grade 3 Follicular Lymphoma|Ann Arbor Stage IV Grade 1 Follicular Lymphoma|Ann Arbor Stage IV Grade 2 Follicular Lymphoma|Ann Arbor Stage IV Grade 3 Follicular Lymphoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Lenalidomide|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: THE BALANCE Study: Treatment of Hyponatremia Based on Lixivaptan in NYHA Class III/IV Cardiac Patient Evaluation
Status: COMPLETED
Conditions: Hyponatremia
Interventions: DRUG: lixivaptan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Different Doses of Amino Acids in 5AA+CrPic Water on Glucose Homeostasis in a Healthy Population.
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: 5AA+CrPic Water|OTHER: Placebo drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Feasibility of a Rehabilitation Programme Targeted Patients Treated With Non-myeloablative Stem Cell Transplantation
Status: COMPLETED
Conditions: Stem Cell Transplantation|Rehabilitation
Interventions: OTHER: Multimodal interdisciplinary rehabilitation programme (HAPPY)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetics of Certoparin in Subjects With Renal Insufficiency and Healthy Subjects
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: DRUG: Certoparin 3,000 IU Once Daily|DRUG: Certoparin 3,000 IU Twice a Day|DRUG: Certoparin 8,000 IU Once Daily|DRUG: Certoparin 8,000 IU Twice a Day
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aromatherapy in Providing a Semen Sample
Status: NOT_YET_RECRUITING
Conditions: Infertility, Male
Interventions: OTHER: Placebo|OTHER: Aromatherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Goal of Open Lung Ventilation in Donors
Status: TERMINATED
Conditions: Brain Death|Organ Donation|Organ Transplant Failure or Rejection
Interventions: OTHER: Open lung protective ventilation|OTHER: Conventional ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Tests in the Context of Threatened Preterm Labour
Status: UNKNOWN
Conditions: Preterm Labor|Immunochromatographic Assay|Predictive Value of Tests|Preterm Delivery|Biomarkers
Interventions: DIAGNOSTIC_TEST: Premaquick (Diagnostic test)|DIAGNOSTIC_TEST: Quikcheck fFN ™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: E4/DRSP Ovarian Function Inhibition Study
Status: COMPLETED
Conditions: Prevention of Pregnancy
Interventions: DRUG: 15 mg E4/3 mg DRSP|DRUG: 20 mcg EE/3 mg DRSP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ultra-high Dose Radiation for Liver Metastasis Using MR-guided TReatment With Stereotactic Ablative Single-fraction
Status: NOT_YET_RECRUITING
Conditions: Liver Metastases
Interventions: RADIATION: Magnetic resonance (MR)-guided stereotactic ablative single-fraction (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT