pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Vinorelbine/Gemcitabine Versus Vinorelbine/Carboplatin in Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Advanced Non-Small Cell Lung Cancer
Interventions: DRUG: Vinorelbine|DRUG: Gemcitabine|DRUG: Vinorelbine|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Prevention of Anastomotic Recurrence by Excluding Mesentery in Crohn's Disease
Status: UNKNOWN
Conditions: Crohn Disease
Interventions: PROCEDURE: Kono anastomosis|PROCEDURE: Stapled side-to-side anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Primary Care to Prevent Childhood Obesity
Status: UNKNOWN
Conditions: Overweight in Preschool Age Children|Risk of Overweight in Preschool Age Children
Interventions: BEHAVIORAL: To change structure and roles of primary care teams to optimize prevention of obesity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Long Term Outcome After Serial Lidocaine Infusion in Peripheral Neuropathic Pain
Status: COMPLETED
Conditions: Peripheral Neuropathy
Interventions: DRUG: Lidocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intergroup Trial for Children or Adolescents With Primary Mediastinal Large B-Cell Lymphoma: DA-EPOCH-Rituximab Evaluation
Status: UNKNOWN
Conditions: Primary Mediastinal Large B Cell Lymphoma
Interventions: DRUG: Etoposide, Doxorubicin, Vincristine, Cyclophosphamide, Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Linkage to Care for Persons With Hep C Infection
Status: RECRUITING
Conditions: Hepatitis C, Chronic|Substance Use Disorders
Interventions: BEHAVIORAL: Peer specialist (PS) and vouchers
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Role of Pulsatile Insulin Secretion (A Study Investigating the Effects of Partial Pacreatectomy on Glucose Metabolism)
Status: COMPLETED
Conditions: Impaired Glucose Tolerance
Interventions: PROCEDURE: All subjects will undergo a 120 minute Oral Glucose Tolerance Test at study visit 2.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: rTMS for Military TBI-related Depression
Status: NOT_YET_RECRUITING
Conditions: Depressive Symptoms|Mild Traumatic Brain Injury|Concussion
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)|DEVICE: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SMART-IBD App Trial
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|IBD|Crohn Disease|Ulcerative Colitis
Interventions: BEHAVIORAL: SMART-IBD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BEYOND Follow-up: Betaferon®/Betaseron® Efficacy Yielding Outcomes of a New Dose
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Interferon beta-1b (Betaseron, BAY86-5046)|DRUG: Interferon beta-1b (Betaseron, BAY86-5046)|DRUG: Interferon beta-1b (Betaseron, BAY86-5046)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: TBE Antibody Persistence and Booster Vaccination Study in Children and Adolescents (Follow-up to Study 209)
Status: COMPLETED
Conditions: Encephalitis, Tick-Borne
Interventions: BIOLOGICAL: Tick-Borne Encephalitis (TBE) Vaccine (Inactivated)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Acute Gastric Variceal Bleeding: Endoscopic Treatment Versus BRTO
Status: UNKNOWN
Conditions: Gastric Varices
Interventions: PROCEDURE: Balloon-occluded retrograde transvenous obliteration|PROCEDURE: Endoscopic cyanoacrylate injection|DRUG: N-butyl-2-cyanoacrylate|DRUG: Lauromacrogol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Patients Undergoing Total Knee and Hip Arthroplasty at a Regional Hospital in Denmark
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee|Arthroplasty, Replacement, Hip
Interventions: OTHER: Arthroplasty and postoperative rehabilitation.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pneumatic Compression Treatment For Upper Extremity Acquired Lymphedema
Status: WITHDRAWN
Conditions: Lymphedema
Interventions: OTHER: Exercise, Elevation, and Compression Garment|DEVICE: E0650 PCD with non-sequential waveform|DEVICE: E0651 PCD with sequential, non-gradient waveform|DEVICE: E0652 PCD with sequential, gradient waveform|DEVICE: E0652 PCD with peristaltic pulse waveform
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-Blind, Placebo-Controlled Study Of Pregabalin In Patients With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: Placebo|DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Salivary Levels of Streptococcus Mutans in Pediatric Patients With Early Childhood Caries After the Application of Silver Diamine Fluoride or 5% Sodium Fluoride Varnish
Status: WITHDRAWN
Conditions: Dental Caries
Interventions: DRUG: Sodium Fluoride|DRUG: Silver diamine fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enteral Nutrition and Glucose Homeostasis
Status: COMPLETED
Conditions: Hyperglycemia Stress
Interventions: OTHER: Diben, Fresenius Kabi|OTHER: Fresubin original fibre, Fresenius Kabi
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Quetiapine Monotherapy in Ambulatory Bipolar Spectrum Disorder With Moderate-to-Severe Hypomanic Symptoms or Mild Manic Symptoms
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants with Active Idiopathic Inflammatory Myopathy.
Status: RECRUITING
Conditions: Active Idiopathic Inflammatory Myopathy|Myositis|Dermatomyositis|Polymyositis|Immune-Mediated Necrotizing Myopathy|Antisynthetase Syndrome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Lignocaine Infusion in Laparoscopic Donor Nephrectomy
Status: UNKNOWN
Conditions: Postoperative Pain|Renal Transplantation|Morphine Adverse Reaction
Interventions: DRUG: Lignocaine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study To Estimate The Time Course Of PF-00241939 Concentration In The Blood Following Dosing By Oral Inhalation From Dry Powder Inhalers.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Treatment A|DRUG: Treatment B|DRUG: Treatment C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Halifax Somatic Symptoms Disorder Trial
Status: COMPLETED
Conditions: Somatic Symptom and Related Disorders|Intensive Short Term Dynamic Psychotherapy
Interventions: BEHAVIORAL: Intensive Short-Term Dynamic Psychotherapy|BEHAVIORAL: Medical Care As Usual (MCAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study of the Safety and Pharmacokinetics of GSK1363089 (Formerly XL880) Administered Orally Daily to Subjects With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumours
Interventions: DRUG: GSK1363089 (formerly XL880)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of Bepirovirsen on Cardiac Conduction as Assessed by 12-lead Electrocardiogram in Healthy Volunteers
Status: NOT_YET_RECRUITING
Conditions: Hepatitis B
Interventions: DRUG: Bepirovirsen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lapatinib in Treating Patients With Recurrent or Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Recurrent Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: lapatinib ditosylate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Placebo Controlled Study With Lovaza in Cardiovascular Disease
Status: COMPLETED
Conditions: HIV Infections|Heart Disease
Interventions: DRUG: Lovaza|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: The Supplementary Role of Non-invasive Imaging to Routine Clinical Practice in Suspected Non-ST-elevation Myocardial Infarction
Status: COMPLETED
Conditions: Chest Pain|Myocardial Infarction|Acute Coronary Syndrome|Coronary Artery Disease|Myocardial Ischemia
Interventions: OTHER: Cardiovascular Magnetic Resonance Imaging|OTHER: Computed Tomography Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Ileocolonic Delivered Vitamins and an Anti-Inflammatory Diet on Crohn's Disease and Healthy Volunteers
Status: RECRUITING
Conditions: Crohn Disease
Interventions: OTHER: Groningen Anti-Inflammatory Diet (GrAID)|DIETARY_SUPPLEMENT: ColoVit capsule|OTHER: ColoPulse-placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of an Internet-based Intervention for the Treatment of Depression
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: ASCENSO|DRUG: Antidepressants or in combination with anxiolytics, neuroleptics or mood stabilizers.|BEHAVIORAL: Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Multi-center Clinical Trial for Evaluating the Effectiveness and Safety of Online Coronary Angiography-Derived Index of Microcirculatory Resistance (caIMR)
Status: COMPLETED
Conditions: Coronary Microvascular Dysfunction
Interventions: DEVICE: Angiography-derived Index of Microcirculatory Resistance|DEVICE: Pressure wire-based Index of Microcirculatory Resistance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis
Status: COMPLETED
Conditions: Atopic Keratoconjunctivitis
Interventions: DRUG: Cyclosporin 0.05% ophthalmic
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telmisartan/Amlodipine (80/10) vs. Telmisartan/Amlodipine (40/10) vs. amlodipine10 in Resistant Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: fixed dose combination of telmisartan+amlodipine|DRUG: amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: 1/2 A Multi-site Systems Intervention for Unemployed Persons With Social Anxiety
Status: COMPLETED
Conditions: Social Anxiety
Interventions: BEHAVIORAL: Vocational Services as usual plus Cognitive Behavioral Therapy (CBT)|BEHAVIORAL: Usual Vocational Services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preop Hemodialysis or Intraop Ultrafiltration for Patients With Severe Renal Dysfunction Undergoing Open Heart Surgery
Status: UNKNOWN
Conditions: Non-Dialysis Dependent Severe Renal Dysfunction|Cardiovascular Disease
Interventions: PROCEDURE: Open Heart Surgery (OHS)|PROCEDURE: Intraoperative Modified Ultrafiltration (MUF)|PROCEDURE: Hemodialysis (HD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-FMAU PET/CT and MRI for the Detection of Brain Tumors in Patients With Brain Cancer or Brain Metastases
Status: COMPLETED
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Clinical Stage IV Cutaneous Melanoma AJCC v8|Glioma|Malignant Brain Neoplasm|Metastatic Breast Carcinoma|Metastatic Colon Carcinoma|Metastatic Kidney Carcinoma|Metastatic Lung Carcinoma|Metastatic Malignant Neoplasm in the Brain|Metastatic Melanoma|Pathologic Stage IV Cutaneous Melanoma AJCC v8|Prognostic Stage IV Breast Cancer AJCC v8|Stage IV Colon Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IV Renal Cell Cancer AJCC v8|Stage IVA Colon Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Colon Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8|Stage IVC Colon Cancer AJCC v8
Interventions: PROCEDURE: Computed Tomography|DRUG: 18F-FMAU|PROCEDURE: Multiparametric Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cardiovascular and Endocrine Response to Muscular Training Program of Young Soccer Players Aged 14-18 Years
Status: NOT_YET_RECRUITING
Conditions: Sport Injury|Hormone Disturbance|Cardiovascular Abnormalities
Interventions: OTHER: neuromuscular programm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase II Study of Pemetrexed Plus Gemcitabine for Metastatic/Recurrent Head and Neck Cancer (HNSCC)
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: Pemetrexed plus Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Emergency Department Probiotic (LGG) Treatment of Pediatric Gastroenteritis
Status: COMPLETED
Conditions: Gastroenteritis
Interventions: DRUG: LGG|DRUG: micro-crystalline cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multidisciplinary Treatment of Obesity Prior to in Vitro Fertilization: Impact on Global Reproductive Outcomes (PRO-FIV Study)
Status: UNKNOWN
Conditions: Obesity|Infertility
Interventions: BEHAVIORAL: Intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Flexible Dose, Long-term Safety Study of Asenapine for the Treatment of Schizophrenia in Adolescents (P05897)
Status: COMPLETED
Conditions: Schizophrenia, Paranoid|Schizophrenia, Disorganized|Schizophrenia, Undifferentiated
Interventions: DRUG: asenapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-flow Nasal Cannula Oxygen Therapy for Ischemic Stroke Patients With Dysphagia and Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Cerebral Infarction|Sleep Apnea, Obstructive|Deglutition Disorders
Interventions: DEVICE: high flow nasal cannula ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Atezolizumab (Tecentriq) in Combination With Bevacizumab to Investigate Safety and Efficacy in Patients With Unresectable Hepatocellular Carcinoma Not Previously Treated With Systemic Therapy-Amethista
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Relative Bioavailability of Brigatinib When Swallowed as a Solution Versus When Swallowed as a Tablet in Healthy Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Brigatinib|DRUG: Brigatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: AcQBlate Force Sensing Ablation System US IDE for Atrial Flutter (AcQForce Flutter)
Status: COMPLETED
Conditions: Typical Atrial Flutter
Interventions: DEVICE: AcQBlate® Force Sensing Ablation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Targinact vs. Oxycodone on Gut Function After Colorectal Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Postoperative Nausea and Vomiting
Interventions: DRUG: Targinact|DRUG: Oxycodone|PROCEDURE: Laparoscopic segmental colectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Metabolic Effects of a High Fructose Versus a High Glucose Diet in Overweight Men
Status: COMPLETED
Conditions: Hepatic Fatty Acid Metabolism|Systemic Insulin Resistance|Oxidative Stress|Cardiovascular Status
Interventions: DIETARY_SUPPLEMENT: high sugar diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Abemaciclib in Recurrent Glioblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: Abemaciclib|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caries Transmission Prevention in Alaska Native Infants
Status: TERMINATED
Conditions: Dental Caries
Interventions: DRUG: Chlorhexidine mouth rinse|OTHER: Xylitol chewing gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase II Trial of Panobinostat and Lenalidomide in Patients With Relapsed or Refractory Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Adult Lymphocyte Depletion Hodgkin Lymphoma|Adult Lymphocyte Predominant Hodgkin Lymphoma|Adult Mixed Cellularity Hodgkin Lymphoma|Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma|Adult Nodular Sclerosis Hodgkin Lymphoma|Recurrent Adult Hodgkin Lymphoma
Interventions: DRUG: panobinostat|DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacological Regulation of Fat Transport in Metabolic Syndrome
Status: COMPLETED
Conditions: Obesity|Lipid Disorders|Hypertriglyceridemia|Cardiovascular Disease
Interventions: DRUG: Atorvastatin and fenofibrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Decitabine as Epigenetic Priming With Induction Chemotherapy in Pediatric Acute Myelogenous Leukemia (AML) Subjects
Status: TERMINATED
Conditions: Pediatric Acute Myelogenous Leukemia (AML)
Interventions: DRUG: Decitabine|DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultra-Hypofractionated vs. Hypofractionated Radiation for Node-Positive Breast Cancer
Status: RECRUITING
Conditions: Node-positive Breast Cancer
Interventions: RADIATION: Hypofractionated radiation|RADIATION: Ultra-hypofractionated breast/chest wall and regional nodal radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DS-8201a in Human Epidermal Growth Factor Receptor2 (HER2)-Expressing Colorectal Cancer (DESTINY-CRC01)
Status: COMPLETED
Conditions: Colorectal Neoplasm
Interventions: DRUG: DS-8201a
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Patupilone After a Single Intravenous Administration in Patients With Advance Solid Tumor Malignancies.
Status: COMPLETED
Conditions: Advanced Malignancies|Solid Tumors
Interventions: DRUG: Patupilone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Amino Acid Supplementation for Patients With an Excessive Loss of Muscular Body Mass After Obesity Surgery.
Status: TERMINATED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Leucine-enriched amino acid supplementation and 30 minutes of physical training 3 times per week
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Safety and Efficacy of ATI-2173 in Combination With Tenofovir Disoproxil Fumarate in Subjects With Chronic Hepatitis B Virus Infection and in Subjects With Hepatitis D Virus Coinfection
Status: TERMINATED
Conditions: Hepatitis B, Chronic|Hepatitis D
Interventions: DRUG: ATI-2173|DRUG: Viread|DRUG: AB-729
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: E_Stethoscope: Portable Digital Auscultation Study on Hypertensive/Hypertensive Heart Disease Patients
Status: UNKNOWN
Conditions: Hypertension|Hypertensive Heart Disease
Interventions: OTHER: Electrocardiogram/Echocardiography|OTHER: Portable digital auscultation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: COVID-19 Convalescent Plasma Treatment in SARS-CoV-2 Infected Patients
Status: UNKNOWN
Conditions: Moderate COVID-19 Pneumonia, Severe COVID-19 Pneumonia|Pneumonia, Viral
Interventions: DRUG: COVID-19 Convalscent Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Silicone Study
Status: COMPLETED
Conditions: Proliferative Vitreoretinopathy|Retinal Detachment
Interventions: DRUG: Perfluoropropane|DRUG: Sulfur Hexafluoride|DRUG: Silicone Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: INcreased Sun Exposure Without Pain In Research Participants With EPP or XLP
Status: RECRUITING
Conditions: Erythropoietic Protoporphyria (EPP)|X-Linked Protoporphyria (XLP)
Interventions: DRUG: Dersimelagon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Addition of Vorinostat to Azacitidine in Higher Risk MDS a Phase II add-on Study in Patients With Azacitidine Failure
Status: TERMINATED
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: Azacitidine and oral vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: From Molecules to Cognition: Inhibitory Mechanisms in ASD and NF1
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Neurofibromatosis 1
Interventions: DRUG: Lovastatin 60 MG|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Relative Bioavailability, Pharmacokinetics, Safety and Tolerability of BIIL 284 BS in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIIL 284 BS boli|DRUG: BIIL 284 BS tablet C|OTHER: standard breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of CYCLOSET ® 0.8 mg Tablets in Children and Adolescent Type 2 Diabetes Mellitus Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Bromocriptine mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Evaluation of Subcutaneous Versus Intravenous Palonosetron in Cancer Treated With Chemotherapy
Status: COMPLETED
Conditions: Emesis
Interventions: DRUG: Palonosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity and Safety of the Concomitant Administration of OVX836 Influenza Vaccine, Quadrivalent Inactivated Influenza Vaccines and Placebo in Healthy Subjects.
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: OVX836 480µg|BIOLOGICAL: Fluarix Tetra|BIOLOGICAL: Afluria Quad|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Desensitization and Cognitive Therapy in General Anxiety.
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: OTHER: Cognitive behavioral therapy (CBT)|BEHAVIORAL: Emotional processing and interpersonal therapy|BEHAVIORAL: Listening therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Lifestyle Intervention on Weight and Fertility in Obese Males
Status: RECRUITING
Conditions: Obesity|Weight Loss|Male Fertility|Artificial Insemination|IVF-ET
Interventions: DIETARY_SUPPLEMENT: Low-carbohydrate diet group|BEHAVIORAL: Health Education Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Imatinib Mesylate in Treating Patients With Stage IV Colorectal Cancer
Status: COMPLETED
Conditions: Recurrent Colon Cancer|Recurrent Rectal Cancer|Stage IV Colon Cancer|Stage IV Rectal Cancer
Interventions: DRUG: imatinib mesylate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Telmisartan/Rosuvastatin Co-administration in Hypertensive Patients With Hyperlipidemia
Status: UNKNOWN
Conditions: Hypertension|Hyperlipidemia
Interventions: DRUG: Telmisartan 80mg|DRUG: Rosuvastatin 20mg|DRUG: Rosuvastatin 10mg|DRUG: Placebo(for Telmisartan 80mg)|DRUG: Placebo(for Rosuvastatin 20mg)|DRUG: Placebo(for Rosuvastatin 10mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aspirin Resistance and Percutaneous Coronary Intervention (PCI)
Status: COMPLETED
Conditions: Stable Angina
Interventions: DRUG: Intravenous Glycoprotein inhibitor + ASA, Clopidogrel|DRUG: Antiplatelet Therapy (ASA, Clopidogrel)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perineural Dexmedetomidine and Femoral Nerve Block
Status: UNKNOWN
Conditions: Onset and Duration of Sensory and Motor Block of Femoral Nerve,|Visual Analogue Pain Scores,|Time to First Request of Rescue Analgesics,|Total Morphine Consumption in 24 Hours
Interventions: DRUG: peri-neural dexmedetomidine as adjuvant to bupivacaine in femoral nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Probiotic Supplementation Reduces Gastrointestinal Symptoms During the Therapy and Improves Therapeutic Response in AL Amyloidosis
Status: NOT_YET_RECRUITING
Conditions: Immunoglobulin Light-chain Amyloidosis
Interventions: DRUG: Live Combined Bacillus Subtilis and Enterococcus Faecium Enteric-coated Capsules combined with Bortezomib+Dexamethasone/Bortezomib+Dexamethasone+Daratumumab/single Daratumumab|DRUG: Bortezomib+Dexamethasone/Bortezomib+Dexamethasone+Daratumumab/single Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioequivalence Study of Nizatidine Capsules 300 mg of Dr.Reddy's Laboratories Limited Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Nizatidine|DRUG: Axid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Penetration of the Innovative Antibiotic Gepotidacin Into Prostate and Tonsillar Tissue
Status: COMPLETED
Conditions: Gonorrhea|Infection, Bacterial
Interventions: DRUG: Gepotidacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b/2a Randomized, Double-Blind, Placebo-controlled, Dose-escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MEDI8897, a Monoclonal Antibody With an Extended Half-life Against Respiratory Syncytial Virus, in Healthy Preterm Infants
Status: COMPLETED
Conditions: Respiratory Syncytial Virus
Interventions: DRUG: Placebo|DRUG: MEDI8897 10 mg|DRUG: MEDI8897 25 mg|DRUG: MEDI8897 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of APL-1202 in Non-Muscle Invasive Bladder Cancer Patients Who Are Resistant to One Induction Course of BCG Treatment
Status: COMPLETED
Conditions: Non-Muscle Invasive Bladder Cancer (NMIBC)
Interventions: DRUG: APL-1202
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Role of Pregabalin in Reducing Opioid Requirement in Spinal Fusion Surgeries of Two or More Vertebrae
Status: TERMINATED
Conditions: Spinal Fusion
Interventions: DRUG: Pregabalin|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaginal Birth After Caesarean Section - Effect on Maternal Psychosocial Function
Status: COMPLETED
Conditions: Pregnancy|Cesarean Section|Uterine Rupture
Interventions: PROCEDURE: Repeat Caesaen section|PROCEDURE: vaginal delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Tolerability of a Single Dose of STX107 in Adults With Fragile X Syndrome
Status: SUSPENDED
Conditions: Fragile X Syndrome
Interventions: DRUG: STX107
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First-in-human Single Ascending Dose/Multiple Ascending Dose Study of ENN0403 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ENN0403 1mg|DRUG: ENN0403 4mg|DRUG: ENN0403 10mg|DRUG: ENN0403 20mg|DRUG: ENN0403 30mg|DRUG: ENN0403 20mg (Fed)|DRUG: ENN0403 6mg QD X 14 Days|DRUG: ENN0403 12mg QD X 14 Days|DRUG: ENN0403 20mg QD X 14 Days|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Accuracy of Detection of Methemoglobin With Pulse Oximetry
Status: COMPLETED
Conditions: Collect Blood Values With Induced Hypoxia, Induced Methemoglobinemia, and Induced Hypoxia and Methemoglobinemia
Interventions: DEVICE: Sensor to spot check blood levels
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of 'Recovery' Footwear on Lower Extremity Comfort and Biomechanics
Status: UNKNOWN
Conditions: Arthralgia|Joint Stiffness|Gait Mechanics
Interventions: DEVICE: OOFOS Recovery Footwear
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Leflunomide or Combination of MEK Inhibitor and Hydroxychloroquine for Refractory Patients With RAS Mutations
Status: RECRUITING
Conditions: RAS Mutation|Ras (Kras or Nras) Gene Mutation|Colorectal Cancer Recurrent|Pancreas Cancer|Lung Cancer|Melanoma|Refractory Cancer
Interventions: DRUG: Leflunomide|DRUG: The combination of MEK inhibitor + hydroxychloroquine( plaquenil) ± bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial of Hypofractionated Intensity Modulated Radiation Therapy With Temozolomide and Granulocyte-macrophage Colony-stimulating Factor for Patients With Newly Diagnosed Glioblastoma Multiforme
Status: UNKNOWN
Conditions: Glioblastoma Multiforme
Interventions: RADIATION: Hypofractionated IMRT|BIOLOGICAL: Granulocyte-macrophage Colony-stimulating Factor|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of High Levels of Energy Expenditure From Physical Activity for Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer Female
Interventions: BEHAVIORAL: Supervised Exercise|BEHAVIORAL: Home-based Exercise|BEHAVIORAL: Group Phone Calls|BEHAVIORAL: Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Cinnamon on Glucose and Lipid Levels in Non-Insulin Dependent Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Adult Onset
Interventions: DRUG: Cinnamon or placebo 500 mg capsule twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Integration of Intraoperative Neuromonitoring Into Decompression Surgery
Status: COMPLETED
Conditions: Nerve Entrapments|Pelvic Pain
Interventions: DEVICE: Intraoperative neurophysiological monitoring with Nicolet Endeavor IOM Machine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Dexmedetomidine on OI, RI and Inflammatory Factors in Patients Undergoing Palatopalatyngoplasty.
Status: UNKNOWN
Conditions: Adverse Effect
Interventions: DRUG: dexmedetomidine|OTHER: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Volasertib and Vincristine Sulfate Liposome in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia
Status: WITHDRAWN
Conditions: Recurrent Adult Acute Lymphoblastic Leukemia|Refractory Adult Acute Lymphoblastic Leukemia
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Vincristine Sulfate Liposome|DRUG: Volasertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrated Smoking Cessation Treatment for Smokers With Serious Mental Illness
Status: COMPLETED
Conditions: Cigarette Smoking|Schizophrenia|Bipolar Disorder|Depressive Disorder, Major|Smoking Cessation
Interventions: OTHER: Academic Detailing|OTHER: Community Health Worker|OTHER: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Varlitinib in Combination With Gemcitabine and Cisplatin for Treatment naïve Advanced or Metastatic BTC
Status: TERMINATED
Conditions: Biliary Tract Cancer
Interventions: DRUG: Varlitinib|DRUG: Cisplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Vitamin D to Treat Contrast-induced Nephropathy
Status: UNKNOWN
Conditions: Contrast-induced Nephropathy
Interventions: DRUG: vitamin D3 tablets|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Alitretinoin Treatment in Patients With Pustular Form of Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: alitretinoin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Trial of Combined Pharmacotherapy to Treat Cocaine Dependence
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: Adderall-ER|DRUG: Topiramate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Venetoclax, Rituximab and Nivolumab in Combination for the Treatment of Richter's Transformation Arising From Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Status: WITHDRAWN
Conditions: Recurrent Transformed Chronic Lymphocytic Leukemia|Refractory Transformed Chronic Lymphocytic Leukemia|Richter Syndrome|Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma|Transformed Small Lymphocytic Lymphoma to Diffuse Large B-Cell Lymphoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Nivolumab|PROCEDURE: Positron Emission Tomography|BIOLOGICAL: Rituximab|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Demonstrate the Efficacy and Safety of Adapalene/Benzoyl Peroxide Topical Gel in Subjects With Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Adapalene/Benzoyl Peroxide|DRUG: Adapalene Gel, 0.1%|DRUG: Benzoyl Peroxide Gel 2.5%|DRUG: Gel Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Plantago Major on Mineral Metabolism and Selected Biochemical Parameters in Obese Women
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Plantago major|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: RC48 Combined With Toripalimab and Radiotherapy for Bladder Sparing Treatment in MIBC
Status: RECRUITING
Conditions: Muscle Invasive Bladder Cancer|HER2 Expression|Radiotherapy|PD-1|Antibody-drug Conjugates
Interventions: DRUG: Disitamab Vedotin and Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Therapy With Dimethylfumarate (DMF) in Patients With Cutaneous T Cell Lymphoma (CTCL)
Status: COMPLETED
Conditions: Cutaneous T Cell Lymphoma
Interventions: DRUG: Dimethyl fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoresection of the Tumor Scar or Transpupillary Thermotherapy for the Treatment of Large Uveal Melanomas (Endoresection-Laser)
Status: ACTIVE_NOT_RECRUITING
Conditions: Uveal Melanoma|Melanoma, Uveal
Interventions: PROCEDURE: Endoresection|PROCEDURE: Laser diode
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK and PD Study of Calcitriol 3 mcg/g Ointment in Pediatric Subjects With Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Calcitriol 3 mcg/g ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Drug Interaction Potential of Luliconazole Cream 1% in Participants With Tinea Pedis and Tinea Cruris
Status: COMPLETED
Conditions: Tinea Pedis|Tinea Cruris
Interventions: DRUG: Omeprazole 40 mg|DRUG: Luliconazole Cream 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metabolic Sodium MRI to Assess Early Response of Breast Cancer to Neoadjuvant Chemotherapy
Status: TERMINATED
Conditions: Breast Cancer|Triple Negative Breast Cancer
Interventions: DIAGNOSTIC_TEST: Sodium (Na) Magnetic Resonance Imaging (MRI)|DIAGNOSTIC_TEST: Dynamic Contrast- Enhanced (DCE) MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: VNS for Long-COVID-19
Status: ACTIVE_NOT_RECRUITING
Conditions: Post-COVID-19 Syndrome|Postural Tachycardia Syndrome|Dysautonomia
Interventions: DEVICE: Non-invasive vagus nerve stimulation|DEVICE: Sham Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Strategy to Improve Pre-Anesthesia Care Discussions (My Anesthesia Choice-Hip Fracture)
Status: NOT_YET_RECRUITING
Conditions: Hip Fractures|Femoral Neck Fractures|Intertrochanteric Fractures|Subtrochanteric Fractures
Interventions: BEHAVIORAL: My Anesthesia Choice-HF Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study on the Safety and Tolerance of Mesenchymal Stem Cells Mediated by Arthroscopy in Patients With Osteoarthritis
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: BIOLOGICAL: Human Umbilical Mesenchymal Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pharmacist Intervention for Individuals With Uncontrolled Type 2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Type 2
Interventions: COMBINATION_PRODUCT: Behavioral and drugs already approved and available for diabetes management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: NCPAP+MISA vs. NIPPV+MISA to NRDS：a Multicenter Randomized Study
Status: UNKNOWN
Conditions: Minimal Invasive Surfactant Administration in Two Different Non-invasive Ventilation Modes to NRDS Infants
Interventions: OTHER: Nasal continuous positive airway pressure and Non-invasive positive pressure ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reduced Carbohydrate Versus Fat in Obese Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: Reduced fat diet|OTHER: Reduced carbohydrate diet|DRUG: Drug: f-18 fallypride|DEVICE: fMRI|DEVICE: PET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Efficacy and Safety of Different Doses of Losartan Potassium (MK0954-011)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: losartan potassium|DRUG: Placebo|DRUG: Enalapril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Somatropin Effect on Linear Growth and Final Height in Subjects With Noonan Syndrome
Status: COMPLETED
Conditions: Genetic Disorder|Noonan Syndrome
Interventions: DRUG: somatropin|DRUG: somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Iron-fortified Pea Powder on Exercise Performance
Status: COMPLETED
Conditions: Iron-deficiency
Interventions: DIETARY_SUPPLEMENT: Low phytate pea powder|DIETARY_SUPPLEMENT: Regular pea powder|DIETARY_SUPPLEMENT: Placebo (maltodextrin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Safety Properties of Metabolic Flow Anesthesia Driven by Automated Gas Control in Pediatric Patients
Status: COMPLETED
Conditions: Anesthesia
Interventions: PROCEDURE: Speed 8 (Fast balancing gas flow)|PROCEDURE: Speed 4 (Medium speed balancing gas flow)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING