pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Comparative Study of Sage-217 Plus an Antidepressant (ADT) Versus Placebo Plus an ADT in Adults With Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: SAGE-217|DRUG: Matching Placebo|DRUG: Sertraline|DRUG: Escitalopram|DRUG: Citalopram|DRUG: Duloxetine|DRUG: Desvenlafaxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Propofol as a Sedative Agent Versus Spinal Analgesia With Bupivacaine in External Cephalic Version
Status: RECRUITING
Conditions: Pregnancy Complications
Interventions: DRUG: Sedation with propofol|DRUG: Spinal analgesia with bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diesel Exhaust Inhalation, Systemic Nitric Oxide Inhibition and Cardiac Output
Status: COMPLETED
Conditions: Vascular Function in Healthy Volunteers
Interventions: DRUG: Intravenous infusion of L-NMMA and Nor-epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Selective Nerve Root Block With Ultrasound Guidance Improves Surgical Outcome of Selective Discectomy in Patients With Multilevel Cervical Disc Disease
Status: COMPLETED
Conditions: Selective Nerve Root Block|Selective Discectomy
Interventions: PROCEDURE: selective anterior cervical discectomy and fusion (ACDF)|PROCEDURE: SNRB+ selective anterior cervical discectomy and fusion (ACDF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Gut Flora Metabolite Reduction After Dietary Intervention (GRADY)
Status: RECRUITING
Conditions: Dietary Modification|Cardiovascular Risk Factor
Interventions: BEHAVIORAL: MeLT Dietary intervention|BEHAVIORAL: TLC Dietary intervention|BEHAVIORAL: MeLT dietary intervention with TMAO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of HMG-coA Reductase Inhibitor on Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Rosuvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SaliPen Human Factors Study for OTC Labeling
Status: COMPLETED
Conditions: Xerostomia
Interventions: DEVICE: Electrical salivary stimulator system assigned to subjects with xerostomia|DEVICE: No Electrical salivary stimulator system assigned to subjects without xerostomia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Perfusion CT in Predicting Outcomes in Ovarian, Fallopian, or Peritoneal Cancer With Bevacizumab
Status: TERMINATED
Conditions: Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma
Interventions: RADIATION: Computed Tomography Perfusion Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Evaluation of Use of Prismocitrate 18 in Patients Undergoing Acute Continuous Renal Replacement Therapy (CRRT)
Status: TERMINATED
Conditions: Regional Citrate Anticoagulation (RCA)|Continuous Renal Replacement Therapy (CRRT)|Acute Kidney Injury
Interventions: DRUG: Prismocitrate 18|OTHER: No Anticoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preperitoneal Versus Pre-trasversalis Hernia Repair
Status: COMPLETED
Conditions: Direct Inguinal Hernia|Indirect Inguinal Hernia
Interventions: PROCEDURE: anterior hernia repair|PROCEDURE: transinguinal preperitoneal patch repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Safety and Efficacy of TG-C in Subjects With Kellgren and Lawrence Grade 2 or 3 OA of the Knee
Status: ACTIVE_NOT_RECRUITING
Conditions: Degenerative Osteoarthritis
Interventions: BIOLOGICAL: TG-C|BIOLOGICAL: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nab-paclitaxel and Gemcitabine vs Gemcitabine Alone as Adjuvant Therapy for Patients With Resected Pancreatic Cancer (the "Apact" Study)
Status: COMPLETED
Conditions: Pancreatic Neoplasms|Digestive System Neoplasms|Neoplasms by Site|Neoplasms|Endocrine Gland Neoplasms|Pancreatic Diseases|Digestive System Diseases|Endocrine System Diseases|Gemcitabine|Antimetabolites, Antineoplastic
Interventions: DRUG: nab-Paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Comprehensive School-based Intervention for High-functioning Children With Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Comprehensive School-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inotuzumab Ozogamicin and Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia
Status: RECRUITING
Conditions: B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative|Burkitt-Like Lymphoma With 11q Aberration|High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements|High Grade B-Cell Lymphoma, Not Otherwise Specified|Recurrent B Acute Lymphoblastic Leukemia|Recurrent Burkitt Lymphoma|Refractory B Acute Lymphoblastic Leukemia|Refractory Burkitt Lymphoma
Interventions: BIOLOGICAL: Blinatumomab|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Dexamethasone|BIOLOGICAL: Inotuzumab Ozogamicin|OTHER: Laboratory Biomarker Analysis|DRUG: Mercaptopurine|DRUG: Methotrexate|DRUG: Prednisone|BIOLOGICAL: Rituximab|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Alloimmune Response in Humoral Rejection After Kidney Transplantation
Status: NOT_YET_RECRUITING
Conditions: Kidney Transplantation|Kidney Allograft Biopsy|Humoral Rejection|Microvascular Inflammation
Interventions: BIOLOGICAL: Blood draw, Urine draw
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Drug Therapies for Salivary Gland Cancers Based on Testing of Genes
Status: ACTIVE_NOT_RECRUITING
Conditions: Salivary Gland Cancer|Metastatic|Advanced|Recurrent
Interventions: DRUG: Selinexor|DRUG: EGFR or HER2 Inhibitor|DRUG: FGFR Inhibitor|DRUG: C-KIT Inhibitor|DRUG: Anti-androgen|DRUG: NOTCH Inhibitor|DRUG: MEK or PI3K Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identifying Optimal Buprenorphine Dosing for Opioid Use Disorder Treatment and Prevention of Overdose
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder
Interventions: DRUG: Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abraxane and Gemcitabine Versus Gemcitabine Alone in Locally Advanced Unresectable Pancreatic Cancer.
Status: COMPLETED
Conditions: Pancreatic Cancer Stage II
Interventions: DRUG: Nab-paclitaxel and Gemcitabine|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Steroid Impregnated Tape in the Treatment of Over-granulating Peritoneal Dialysis Exit Sites
Status: COMPLETED
Conditions: Peritoneal Dialysis|Continuous Ambulatory Peritoneal Dialysis|End Stage Renal Failure|Chronic Renal Failure
Interventions: DRUG: Haelan tape (steroid impregnated tape)|DRUG: Silver Nitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Combined Tdap Vaccine Used As A Booster Compared To Licensed Td Vaccine
Status: COMPLETED
Conditions: Diphtheria|Tetanus|Acellular Pertussis
Interventions: BIOLOGICAL: Combined diphtheria, tetanus, acellular pertussis vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: An Investigational Drug Study In Patients With COPD (Chronic Obstructive Pulmonary Disease) (MK-0873-005)
Status: TERMINATED
Conditions: Lung Diseases|Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: MK-0873 2.5 mg|DRUG: MK-0873 1.25 mg|DRUG: MK-0873 0.75 mg|DRUG: Placebo to MK-0873|DRUG: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Talazoparib and HSP90 Inhibitor AT13387 in Treating Patients With Metastatic Advanced Solid Tumor or Recurrent Ovarian, Fallopian Tube, Primary Peritoneal, or Triple Negative Breast Cancer
Status: WITHDRAWN
Conditions: Adult Solid Neoplasm|Estrogen Receptor Negative|Fallopian Tube Serous Neoplasm|HER2/Neu Negative|Ovarian Serous Adenocarcinoma|Ovarian Serous Tumor|Primary Peritoneal Serous Adenocarcinoma|Progesterone Receptor Negative|Recurrent Breast Carcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Triple-Negative Breast Carcinoma
Interventions: DRUG: Hsp90 Inhibitor AT13387|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Talazoparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Assess the Safety and Pharmacokinetics of SRT2104 in Normal Healthy Male Volunteers
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Healthy Volunteer
Interventions: DRUG: SRT2104|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementia (IBMPFD)
Status: RECRUITING
Conditions: Inclusion Body Myopathy With Early-onset Paget Disease and Frontotemporal Dementia|Paget Disease of Bone|Frontotemporal Dementia|Myopathy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CONNEX-3: A Study to Test Whether Iclepertin Improves Learning and Memory in People With Schizophrenia
Status: ACTIVE_NOT_RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: iclepertin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Artemisinin-based Combination Therapies on Schistosomiasis on Malaria Co-infection
Status: COMPLETED
Conditions: Schistosomiasis Haematobia
Interventions: DRUG: Artesunate-Pyronaridine|DRUG: Artemether-Lumefantrine|DRUG: Artefenomel-Ferroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diffusion-weighted Cerebral MRI and Intra Uterine Growth Restriction.
Status: COMPLETED
Conditions: Pregnant Women With Foetuses Presenting With Intra-uterine Growth Restriction
Interventions: RADIATION: Pregnant women with intra-uterine growth restricted Foetuses
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Lipoprotein Turnover on Low- and High-MUFA Portfolio Diets
Status: COMPLETED
Conditions: Hyperlipidemia|Cardiovascular Diseases|Diet Therapy
Interventions: PROCEDURE: High MUFA dietary portfolio|PROCEDURE: Low MUFA dietary portfolio
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DIalysis Symptom COntrol-Restless Legs Syndrome Trial
Status: COMPLETED
Conditions: End Stage Renal Disease|Restless Legs Syndrome
Interventions: DRUG: Gabapentin|DRUG: Ropinirole|DRUG: Placebo Gabapentin|DRUG: Placebo Ropinirole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeted Busulfan, Fludarabine Conditioning Regimen for Hematopoietic Stem Cell Transplantation in GRD
Status: RECRUITING
Conditions: Genetic Rare Disease
Interventions: DRUG: Busulfan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Study Comparing the Efficacy, Safety and Tolerability of Oral Dydrogesterone 30 mg Daily Versus Intravaginal Micronized Progesterone Capsules 600 mg Daily for Luteal Support in In-Vitro Fertilization
Status: COMPLETED
Conditions: Female Infertility
Interventions: DRUG: Dydrogesterone 30 mg|DRUG: Micronized Progesterone 600 mg|DRUG: Placebo progesterone|DRUG: Placebo dydrogesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial To Assess Safety And Efficacy Of Influenza Virus Vaccine, Trivalent, Types A & B, Live Cold-Adapted (CAIV-T) In Adults Aged 60 Years And Older
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: CAIV-T
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Vagal Nerve Stimulation in Alcohol Use Disorder
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: DEVICE: Cervical transcutaneous vagus nerve stimulation (active comparator)|DEVICE: Cervical transcutaneous vagus nerve stimulation (sham comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Nirmatrelvir & Ritonavir From Copaxid 150 +100 mg Tablets (Eva Pharma, Egypt) Versus Paxlovid 150 + 100 mg Film Coated Tablets (Pfizer Europe, Belgium)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Nirmatrelvir 150 mg + Ritonavir 100 mg (Reference first dose)|DRUG: Nirmatrelvir 150 mg + Ritonavir 100 mg (test)|DRUG: Nirmatrelvir 150 mg + Ritonavir 100 mg (Reference second dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: In Vitro Organoid Drug Sensitivity-Guided Treatment for Advanced Pancreatic Neuroendocrine Tumor
Status: RECRUITING
Conditions: Advanced Pancreatic Neuroendocrine Tumor
Interventions: OTHER: Chemotherapy and targeted-therapy guided by organoid drug sensitivity test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for the Sleep Disorder of Chronic Fatigue Syndrome
Status: COMPLETED
Conditions: Chronic Fatigue Syndrome
Interventions: DEVICE: Acupuncture|DEVICE: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Dengue Vaccine in Healthy Children
Status: COMPLETED
Conditions: Dengue Virus|Dengue Fever|Dengue Hemorrhagic Fever|Dengue Diseases
Interventions: BIOLOGICAL: CYD Dengue Vaccine|BIOLOGICAL: Inactivated rabies virus vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Effects of Dexmedetomidine and Ketofol for Sedation in Patients Undergoing Trans-esophageal Echocardiography
Status: COMPLETED
Conditions: Heart Valve Disease|Heart Septal Defects, Atrial
Interventions: DRUG: Dexmedetomidine|DRUG: Ketofol(ketamine+propofol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinical Effectiveness of Enteric Coated(E.C.) Anise-oil on Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Anise-oil EC Capsule|OTHER: Placebo|DRUG: Colpermin®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intracervical Catheters for Induction of Labour in Women With Prelabour Rupture of Membranes at Term
Status: TERMINATED
Conditions: Fetal Membranes, Premature Rupture|Induced Labor
Interventions: PROCEDURE: Intracervical Balloon Catheter|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Fitness for Depression in Older Adults
Status: RECRUITING
Conditions: Depression Mild|Depressive Disorder, Major|Mild Cognitive Impairment
Interventions: OTHER: Computerized Cognitive Remediation of Executive Functioning (CCR-EF)|OTHER: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Balance Rehabilitation With Modified Visual Input in Patients With Neuropathy
Status: RECRUITING
Conditions: Neuropathy|Ataxia|Proprioceptive Disorders|Balance; Distorted
Interventions: OTHER: Balance rehabilitation with modified visual input|OTHER: Balance rehabilitation with no modified visual input
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety/Efficacy of a Single Pre-Op Dose of AYX1 Injection to Treat Pain After Knee Replacement Surgery
Status: COMPLETED
Conditions: Postsurgical Pain
Interventions: DRUG: Placebo Injection|DRUG: AYX1 Injection 110 mg|DRUG: AYX1 Injection 330 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Definitive QT Study With MT-8554
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: MT-8554 Low dose|DRUG: MT-8554 High dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinico-Pathologic-Genetic-Imaging Study of Neurodegenerative and Related Disorders
Status: ENROLLING_BY_INVITATION
Conditions: PSP|CBD|PCA|LPA|Semantic Dementia|Semantic Aphasia|Behavioral Variant of Frontotemporal Dementia|FTD|PPA|Apraxia of Speech|MSA - Multiple System Atrophy|Parkinson Disease
Interventions: DRUG: C-11 PiB|DRUG: AV1451 Tau|DRUG: C-11 ER176
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Physical Therapy for Improving Functionality, Gait and Participation in Cerebral Palsy
Status: RECRUITING
Conditions: Physical Therapy|Cerebral Palsy|Therapeutic Education|Telehealth
Interventions: OTHER: Physical Therapy|OTHER: THERAPEUTIC EDUCATION PROGRAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Oxytocin Nasal Sprays on Social Behavior in Social Anxiety Disorder
Status: COMPLETED
Conditions: Social Anxiety Disorder
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Comparison of a Sheathed to a Standard Speculum for Visualization of the Cervix
Status: COMPLETED
Conditions: Comparison of a Sheathed Versus Standard Plastic Speculum
Interventions: PROCEDURE: Sheathed speculum examination|PROCEDURE: Standard speculum examination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: CYCLE Pilot Randomized Trial
Status: COMPLETED
Conditions: Intensive Care Unit Acquired Weakness|Critical Care|Mechanical Ventilation|Respiratory Failure
Interventions: DEVICE: In-bed cycle ergometer (Restorative Therapies RT300 Supine)|OTHER: Routine physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Westlake Precision Nutrition Study 2 (WePrecision2)
Status: COMPLETED
Conditions: Healthy|Overweight and Obesity
Interventions: OTHER: refined carbohydrate breakfast|OTHER: whole grain breakfast|OTHER: energy-restricted diet|OTHER: time-restricted diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of Interventional Pulmonologic Treatment of Malignant Central Airway Stricture
Status: UNKNOWN
Conditions: Airway Obstruction
Interventions: PROCEDURE: cryotherapy|PROCEDURE: argon plasma coagulation|PROCEDURE: stent placement|PROCEDURE: deletion tumor tissue by snare
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MK-0941 Multiple Dose Study in Japanese Patients With Type 2 Diabetes (MK-0941-011).
Status: COMPLETED
Conditions: Diabetes Mellitus, Non-Insulin-Dependent
Interventions: DRUG: Placebo|DRUG: MK-0941
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Study the Effects of Two Drugs, Vildagliptin and Metformin in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: TYpe 2 Diabetes Mellitus
Interventions: DRUG: Metformin|DRUG: Vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Severe Aortic Stenosis and Acquired Von Willebrand´s Disease: The Impact of Desmopressin in Valve-Replacement Surgery
Status: COMPLETED
Conditions: Acquired Von Willebrand Disease Secondary to Severe Aortic Stenosis|Heye´s Syndrome|Severe Aortic Stenosis
Interventions: DRUG: desmopressin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Red Blood Cell Integrity and Efficiency of Recovery Using a Novel Surgical Sponge-Blood Recovery Device (ProCell): Immediate Impact
Status: RECRUITING
Conditions: Blood Recovery
Interventions: PROCEDURE: Hand Wrung|DEVICE: ProCell Wrung
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing Two Diets in Patients Undergoing HSCT or Remission Induction Chemo for Acute Leukemia and MDS (UF-BMT-LDND-101)
Status: TERMINATED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: OTHER: Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: AK104 Combining With TACE for Resectable Hepatocellular Carcinoma (MORNING)
Status: NOT_YET_RECRUITING
Conditions: Resectable Hepatocellular Carcinoma
Interventions: DRUG: Cadonilimab|PROCEDURE: TACE|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bendamustine With Irinotecan Followed by Etoposide/Carboplatin for Patients With Extensive Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Small Cell Lung Cancer|Extensive Stage Lung Cancer|Chemonaive
Interventions: DRUG: Novel Drug Combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intravenous Lidocaine on Postoperative Pain and Recovery in Patients Undergoing Hepatectomy
Status: COMPLETED
Conditions: Primary Liver Cancer
Interventions: DRUG: Lidocaine Hydrochloride, Injectable|DRUG: 0.9% normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Fatty Acids Monotherapy in Children and Adolescents With Autism Spectrum Disorders
Status: TERMINATED
Conditions: Autism Spectrum Disorder (ASD)
Interventions: DRUG: Omega-3 Fatty Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Continuous Positive Airway Pressure for Tumor Motion Management in Radiotherapy
Status: UNKNOWN
Conditions: Tumor Motion|"Continuous Positive Airway Pressure"|Lung Cancer|Breast Cancer|Abdominal Tumors
Interventions: DEVICE: Continuous positive airway pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-Thoracic Epidural Anesthesia For Laparoscopic Nephrectomy.
Status: RECRUITING
Conditions: Laparoscopic|Nephrectomy|Anesthesia|Epidural
Interventions: PROCEDURE: Low-Thoracic Epidural Anesthesia|PROCEDURE: General Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vaginal Infection Study
Status: COMPLETED
Conditions: Vulvovaginitis|Vaginitis
Interventions: DRUG: clindamycin phosphate/butoconazole nitrate|DRUG: clindamycin phosphate|DRUG: butoconazole nitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Indomethacin on Retinal and Choroidal Blood Flow in Healthy Volunteers
Status: COMPLETED
Conditions: Ocular Physiology|Regional Blood Flow
Interventions: DRUG: indometacine (drug) effect on ocular blood flow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose:
Clinical trial: Safety and Efficacy of PegIntron Plus Rebetol in Patients With Chronic Hepatitis C in Japan, Excluding (1) Subjects With HCV Genotype 1 and High Viral Load, and (2) Interferon-naïve Subjects With Low Viral Load (Study P04841)(COMPLETED)
Status: COMPLETED
Conditions: Hepatitis C, Chronic|Hepatitis C
Interventions: DRUG: PegIntron (peginterferon alfa-2b; SCH 54031)|DRUG: Rebetol (ribavirin; SCH 18908)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate the Efficacy and Safety of Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Armodafinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Addition of Hyaluronidase to Lidocaine and Bupivacaine in Scalp Nerves Block in Elective Craniotomy Operations, Comparative Study
Status: COMPLETED
Conditions: Addition of Hyalase to Local Anesthetic in Scalp Block
Interventions: DRUG: Hyaluronidase|DRUG: Lidocaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial of Nortriptyline and Topiramate in the Initial Treatment of Vestibular Migraine
Status: TERMINATED
Conditions: Migraine Disorders
Interventions: DRUG: nortriptyline|DRUG: Topiramate|BEHAVIORAL: Diet Modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization
Status: COMPLETED
Conditions: Corneal Neovascularization
Interventions: DRUG: Dihematoporphyrin derivative|DRUG: prednisolone|PROCEDURE: Laser surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of SPN-812 (Viloxazine Extended-release Capsule) Low Dose in Children With ADHD
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: Placebo|DRUG: 100mg SPN-812|DRUG: 200mg SPN-812
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Palbociclib for HR Positive / HER2-negative Isolated Locoregional Recurrence of Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer Recurrent
Interventions: DRUG: Palbociclib 125mg|DRUG: Standard endocrine therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Stimuli of Transcutaneous Electric Acupoint Stimulation(TEAS) on Acupuncture Anesthesia
Status: UNKNOWN
Conditions: Acupuncture
Interventions: DEVICE: TEAS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pulse Glucocorticoid Therapy in Patients With ST-Segment Elevation Myocardial Infarction
Status: ACTIVE_NOT_RECRUITING
Conditions: ST Elevation Myocardial Infarction|Inflammatory Response|Myocardial Reperfusion Injury|Myocardial Injury
Interventions: DRUG: Methylprednisolone|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radial Extracorporeal Shock Wave Therapy (rESWT) Treatment of Subacromial Shoulder Pain
Status: UNKNOWN
Conditions: Shoulder Impingement Syndrome|Subacromial Shoulder Pain
Interventions: DEVICE: Radial extracorporeal shock wave therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anatomical Relationship of Level IB Lymph Nodes to the Submandibular Gland in Cancer Patients
Status: COMPLETED
Conditions: Carcinoma
Interventions: PROCEDURE: neck dissection of at least the ipsilateral sub-level 1B
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Point-of-care Measurement of the Antifibrinolytic Activity of Tranexamic Acid in Cardiac Surgery
Status: RECRUITING
Conditions: Antifibrinolytic Agents
Interventions: DRUG: Tranexamic acid bolus 20 mg/kg|DRUG: Tranexamic acid bolus 10 mg/kg|DRUG: Tranexamic acid bolus 1 mg/kg|DRUG: Tranexamic acid continuous infusion of 1 mg/kg/h in the low dose group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Change in Symptom and Quality of Life in COPD by Budesonide/Glycopyrronium/Formoterol Fumarate Pressurized Metered Dose Inhaler (BGF pMDI)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Milrinone in Congenital Diaphragmatic Hernia
Status: ACTIVE_NOT_RECRUITING
Conditions: Congenital Diaphragmatic Hernia|Persistent Pulmonary Hypertension of the Newborn|Hypoxemic Respiratory Failure|Pulmonary Hypoplasia
Interventions: DRUG: Milrinone|DRUG: Placebo (5% Dextrose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanism of Analgesic Effect on Prolonged Continuous Theta Burst Stimulation
Status: COMPLETED
Conditions: Chronic Pain|rTMS
Interventions: DRUG: Naloxone|DRUG: Saline|DRUG: Ketamine Hydrochloride|DEVICE: pcTBS of M1|DEVICE: pcTBS of DLPFC|DEVICE: SHAM stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Impact of Magnesium Supplementation on Insulin Resistance and Secretion in Renal Transplant Recipients
Status: COMPLETED
Conditions: Glucose Metabolism|Renal Transplantation
Interventions: DIETARY_SUPPLEMENT: magnesium supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Safety and Effectiveness of a Connective Tissue Allograft (ActiveMatrix) Verses Standard of Care in Adhesive Capsulitis of the Shoulder
Status: RECRUITING
Conditions: Adhesive Capsulitis
Interventions: DRUG: Corticosteroid|OTHER: ActiveMatrix|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ringer Acetate Based Modified Del Nido Cardioplegia Solution Versus HTK Solution Cardioplegia Solution in Cardiac Surgery
Status: NOT_YET_RECRUITING
Conditions: Cardiac Ischemia
Interventions: BIOLOGICAL: Ringer acetate based Del Nido cardioplegia|BIOLOGICAL: HTK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Olanzapine in the Treatment of Anorexia Nervosa
Status: COMPLETED
Conditions: Anorexia Nervosa
Interventions: DRUG: olanzapine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Azilect® (Rasagiline) in Levodopa-treated Parkinson's Patients With Motor Fluctuations in China
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Placebo|DRUG: Azilect®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Modakafusp Alfa on Adult Participants With Relapsed/Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Modakafusp alfa|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate Somo•v and Digital Mammography Together as a Breast Cancer Screening Method, Compared to Digital Mammography Alone, in Women With Dense Breasts.
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DEVICE: Automated Breast Ultrasound (ABUS) as an adjunct to digital screening mammography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of ISIS 416858 Administered Subcutaneously to Participants With End-Stage Renal Disease (ESRD) on Hemodialysis
Status: COMPLETED
Conditions: End-stage Renal Disease (ESRD)
Interventions: DRUG: ISIS 416858|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dinutuximab and Irinotecan Versus Irinotecan to Treat Subjects With Relapsed or Refractory Small Cell Lung Cancer
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: BIOLOGICAL: Dinutuximab|DRUG: Irinotecan|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Left Atrial Appendage Electrical Isolation and Occlusion to Treat Persistent Atrial Fibrillation: A Safety and Feasibility Study
Status: UNKNOWN
Conditions: Persistent Atrial Fibrillation
Interventions: PROCEDURE: LAA electrical isolation + occlusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SEAM Trial: Sutureless End to End Anastomosis by Magnetic Compression
Status: RECRUITING
Conditions: Retraction of Ileostomy
Interventions: DEVICE: Ileostomy Reversal using Self Forming Magnets (SFM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of the Safety and Efficacy of BCMA CAR-NK
Status: RECRUITING
Conditions: Immunotherapy|Multiple Myeloma
Interventions: DRUG: Chimeric Antigen Receptor NK Cell Injection Targeting BCMA (BCMA CAR-NK)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proposal for Parental Guidance and Early Stimulation in Children With Congenital Heart Disease: Randomized Trial
Status: COMPLETED
Conditions: Congenital Heart Disease
Interventions: OTHER: Early stimulation protocol on neuropsychomotor development of children with congenital heart disease
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Iptacopan (LNP023) in Adult Patients With Atypical Hemolytic Uremic Syndrome Naive to Complement Inhibitor Therapy
Status: RECRUITING
Conditions: Atypical Hemolytic Uremic Syndrome
Interventions: DRUG: Iptacopan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The COCOA-PAD II Trial
Status: RECRUITING
Conditions: Peripheral Artery Disease
Interventions: DRUG: cocoa flavanols|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 3D-printing and Acces to Tele Rehabilitation
Status: COMPLETED
Conditions: Orthopedic Disorder
Interventions: DEVICE: Ankle Foot Orthosis (AFO)|DEVICE: Knee Ankle Foot Orthosis (KAFO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MultiPAP Plus: Improving Prescription in Primary Care Patients With Multimorbidity and Polypharmacy
Status: COMPLETED
Conditions: Multimorbidity|Polypharmacy|Comorbidities and Coexisting Conditions|Clinical Decision-Support Systems
Interventions: OTHER: MultiPAP Plus|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Interscalene Catheter to Single Injection Interscalene Blocks for Total Shoulder Arthroplasties
Status: RECRUITING
Conditions: Post Operative Pain|Anesthesia|Nerve Block|Shoulder Osteoarthritis
Interventions: PROCEDURE: Interscalene Catheter|PROCEDURE: Exparel Single Shot Interscalene Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Ph II Bevacizumab + Etoposide for Pts w Recurrent MG
Status: COMPLETED
Conditions: Glioblastoma|Gliosarcoma
Interventions: DRUG: Bevacizumab and Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Pain Relief Between Exparel® Injection vs. On-Q Catheter as the Postsurgical Analgesia Following Total Knee Arthroplasty (TKA)
Status: COMPLETED
Conditions: Osteoarthritis: Joint Replacement Surgery
Interventions: DRUG: Exparel|DRUG: On-Q pain intra-articular catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Fluoxetine for Visual Recovery After Ischemic Stroke
Status: TERMINATED
Conditions: Acute Stroke|Visual Field Loss
Interventions: DRUG: Fluoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preserving Muscle Mass and Function in Bedridden Older Adults
Status: COMPLETED
Conditions: Bed Rest
Interventions: DIETARY_SUPPLEMENT: Leucine|BEHAVIORAL: Exercise|DIETARY_SUPPLEMENT: Whey protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess Safety of ImbruvicaTM in Indian Participants With Chronic Lymphocytic Leukemia or Mantle Cell Lymphoma Who Have Received at Least One Prior Therapy or Chronic Lymphocytic Leukemia With 17p Deletion
Status: COMPLETED
Conditions: Leukemia, Lymphocytic, Chronic, B-Cell|Lymphoma, Mantle-Cell
Interventions: DRUG: Ibrutinib 420 mg|DRUG: Ibrutinib 560 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Role of Antisecretory Factor in Dihydropyrimidine Treatment of Colorectal Cancer
Status: RECRUITING
Conditions: Dihydropyrimidine Induced Gastrointestinal Toxicity in Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: Salovum and SPC-flakes active or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Azilsartan Medoxomil Used in Combination With Metformin in Participants With Hypertension and Diabetes
Status: TERMINATED
Conditions: Hypertension|Diabetes
Interventions: DRUG: Placebo|DRUG: Azilsartan medoxomil|DRUG: Azilsartan medoxomil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Complete Lesion Assessment With ffR and IVUS TechnologY
Status: COMPLETED
Conditions: Peripheral Artery Disease|Critical Limb Ischemia
Interventions: DEVICE: Orbital Atherectomy System|DEVICE: Balloon Angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation for Attention Deficit
Status: COMPLETED
Conditions: Infantile Hemiplegia
Interventions: DEVICE: transcranial direct current stimulation|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Inorganic Nitrate for the Prevention of Contrast-induced Nephropathy
Status: COMPLETED
Conditions: Contrast-induced Nephropathy|Acute Kidney Injury|Acute Coronary Syndrome
Interventions: DRUG: Potassium Nitrate|DRUG: Potassium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Axillary Sentinel or Targeted Lymph Node Biopsy Alone After Neoadjuvant Chemotherapy in Node-positive Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer Female
Interventions: PROCEDURE: sentinel lymph node biopsy or targeted axillary dissection alone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of the Effectiveness Of Pomegranate Pills in Men With Prostate Cancer Before Prostatectomy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: Pomegranate pill|DIETARY_SUPPLEMENT: Pomegranate pill placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction
Status: SUSPENDED
Conditions: Heart Failure With Preserved Ejection Fraction|Concentric Hypertrophy
Interventions: DEVICE: Pacemaker PLR + TRT ON|DEVICE: Pacemaker non-pacing mode or an exertional rate-adaptive pacing mode with no planned pacing at rest.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cisplatin and Paclitaxel With or Without Everolimus in Treating Patients With Stage II or Stage III Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: cisplatin|DRUG: everolimus|DRUG: paclitaxel|OTHER: placebo|PROCEDURE: Venous blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, & Pharmacokinetics Study of Single & Multiple Inhaled Doses of Imatinib Inhalation Solution
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: AER-901 Solution for Nebulization|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Regional or Extend LymphAdenectomy During Resection of Intrahepatic Cholangiocarcinoma
Status: RECRUITING
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: PROCEDURE: Extend LymphAdenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT