pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Clinical Trial Comparing the Pharmacological Effects of EP395 With Placebo in Healthy Adults
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|COPD
Interventions: DRUG: EP395|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Correlates of Multimodal Rehabilitation in Chronic Post-stroke Aphasia
Status: COMPLETED
Conditions: Aphasia|Stroke
Interventions: DRUG: Donepezil|BEHAVIORAL: Intensive-Language Action Therapy|DEVICE: Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 'Palliative-D' Vitamin D to Palliative Cancer Patients
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DRUG: Cholecalciferol|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Omega-3 Polyunsaturated Fatty Acids in Morbidly Obese to Reduce Liver Volume and Steatosis
Status: COMPLETED
Conditions: Morbid Obesity D009765
Interventions: DRUG: Omega-3 Fatty Acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Measuring Asthma Control In Pediatric And Adolescent Subjects Whose Asthma Is Worsened By Activity Or Exercise
Status: COMPLETED
Conditions: Bronchospasm|Activity/Exercise Induced Bronchospasm
Interventions: DRUG: Fluticasone propionate/salmeterol|DRUG: Fluticasone Propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Efficacy of Vemurafenib in Combination With Cobimetinib (Continuous and Intermittent) in BRAFV600-mutation Positive Patients With Unresectable Locally Advanced or Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: vemurafenib and cobimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effects of Pilates and McKenzie in Power Looms Workers Having Nonspecific Chronic Low Back Pain
Status: COMPLETED
Conditions: Nonspecific Chronic Low Back Pain|Pain|Disability Physical
Interventions: OTHER: McKenzie back extension exercise|OTHER: Pilates pelvic tilt exercise|OTHER: Baseline treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Epidural Dexamethasone Versus Betamethasone for Treatment of Lumbosacral Radiculalgia
Status: UNKNOWN
Conditions: Chronic Pain
Interventions: DRUG: Betamethasone|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Crossbow Versus Forsus Springs in Mild to Moderate Class II Malocclusion Cases
Status: COMPLETED
Conditions: Malocclusion, Angle Class II
Interventions: DEVICE: Brackets plus Forsus springs|DEVICE: Xbow plus full brackets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Same Day Discharge for Video-Assisted Thoracoscopic Surgery (VATS) Lung Surgery
Status: RECRUITING
Conditions: Lung Cancer|Surgery
Interventions: PROCEDURE: Same Day Discharge - Video-Assisted Thoracoscopic Surgery (VATS) Lung
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accuracy of a Portable International Normalized Ratio Monitor in Elderly Patients
Status: UNKNOWN
Conditions: Blood Coagulation Disorders|Blood Coagulation Disorder With Prolonged Bleeding Time|Blood Coagulation Disorder With Prolonged Coagulation Time
Interventions: DEVICE: INR capillary measurement with INRatio 2 device|OTHER: antiphospholipid antibodies and lupus anticoagulant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Cog-VACCINE: Cognitive Training in Patients With Vascular Cognitive Impairment, no Dementia
Status: COMPLETED
Conditions: Vascular Cognitive Impairment no Dementia
Interventions: BEHAVIORAL: multi-domain internet-based adaptive training program|BEHAVIORAL: placebo program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Curcumin on Markers of Cardiovascular Risk in Patients With CAD
Status: WITHDRAWN
Conditions: Coronary Artery Disease|Oxidative Stress|Inflammation
Interventions: DIETARY_SUPPLEMENT: Curcumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Iberdomide|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate Long-term Efficacy and Safety of Lozenges Containing Lactobacilli Reuteri (Prodentis™) on Gingivitis
Status: COMPLETED
Conditions: Gingivitis
Interventions: OTHER: Probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of Surufatinib as Adjuvant Therapy for Pancreatic Neuroendocrine Tumors
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Neuroendocrine Tumor
Interventions: DRUG: Surufatinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Use of Mifepristone in the Treatment of Adenomyosis
Status: UNKNOWN
Conditions: Adenomyosis|Mifepristone
Interventions: DRUG: mifepristone|DRUG: Triptorelin Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of a Preclinical Model Based on Patient-derived Organoids for the Study of the Gut-joint Axis in Spondyloarthritis
Status: RECRUITING
Conditions: Spondyloarthritis|Inflammatory Bowel Diseases
Interventions: PROCEDURE: Synovial ultrasound-guided biopsy Intestinal biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunogenicity and Safety of a Trivalent Inactivated Influenza Vaccine, Formulation 2010-2011, in Non-Elderly Adult and Elderly Subjects
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: AdimFlu-S Vaccine 2010-2011
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PRospective Study to Evaluate EffectivenesS With the NURO™ PErcutaneous Tibial Neuromodulation System in Patients With OAB
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DEVICE: NURO System PTNM Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuropathic Pain in Patients With Cancer
Status: COMPLETED
Conditions: Neuropathic Pain
Interventions: DRUG: KRN5500|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Detection of Esophageal Squamous Cancer With the Capsule Sponge Device
Status: NOT_YET_RECRUITING
Conditions: Esophageal Cancer|Head and Neck Cancer|Squamous Cell Carcinoma
Interventions: DEVICE: Capsule-sponge
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Determine MTD and to Evaluate pk, Safety/Tolerability and Efficacy Profiles of Hocena® in NSCLC Subjects
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Antroquinonol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Operative Outcomes of Low Thermal Dissection vs. Traditional Electrosurgery
Status: COMPLETED
Conditions: Breast Cancer|Mastectomy|Perfusion; Complications|Hemostasis
Interventions: DEVICE: PlasmaBlade 3.0S
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effect of TU-100 on Rectal Compliance, Rectal Sensation and Small Bowel and Colonic Transit in Females With Constipation
Status: COMPLETED
Conditions: Functional Constipation|Gastric Emptying|Whole Gut Transit|Small Bowel Transit|Colonic Transit|Rectal Compliance|Rectal Sensation
Interventions: DRUG: Daikenchuto (TU-100)|DRUG: Daikenchuto (TU-100)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Combined Personalized Nutritional Intervention and a Personalized Graded Activity Functional Training Program on Physical Performance in Hospitalized Older Patients, Compared to Usual Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Old Age; Atrophy
Interventions: BEHAVIORAL: FITFOOD lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Five Selected Markers in Skin Biopsies of Patients With Postherpetic Neuralgia and Healthy Controls
Status: COMPLETED
Conditions: Postherpetic Neuralgia|Healthy Age/Gender Matched Volunteers
Interventions: OTHER: skin biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Red Blood Cell Survival on a Commonly Used Diabetes Lab Test-HbA1c
Status: TERMINATED
Conditions: Diabetes Mellitus|Impaired Fasting Glucose|Prediabetes
Interventions: BIOLOGICAL: re-infusion of biotin labeled cells|BIOLOGICAL: Re-infusion of biotin labeled cells|BEHAVIORAL: Diabetes education/diabetes medication adjustment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Characterize Demographics, Compliance, Tolerability and Safety in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Prescribed Adalimumab (Humira®) as Part of Routine Clinical Care
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Psoriatic Arthritis|Ankylosing Spondylitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Venetoclax in Combination With Pomalidomide and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Venetoclax|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Clinical Study of HS-20117 in Participants With Advanced Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Non-Small Cell Lung Cancer|Solid Tumor
Interventions: DRUG: HS-20117
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRI-Based Structural Changes in Lumber Spine in Subjects With Discogenic Low Back Pain After Mckenzie Exercises.
Status: RECRUITING
Conditions: Mechanical Low Back Pain
Interventions: OTHER: Mckenzie Extension Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Peroxide Level in Saliva During Teeth Bleaching Using a Tray With Reservoir Versus a Tray Without Reservoir.
Status: COMPLETED
Conditions: Consumption
Interventions: PROCEDURE: Assessment of hydrogen peroxide levels in saliva using trays with reservoir.|PROCEDURE: Assessment of hydrogen peroxide levels in saliva using trays without reservoir.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of the Hutchinson-Gilford Progeria Syndrome With a Combination of Pravastatin and Zoledronic Acid
Status: COMPLETED
Conditions: Hutchinson-Gilford Progeria Syndrome
Interventions: DRUG: Zoledronic acid, pravastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective RegIstration Of the peRformance of the IoTa ADNEX Model in Dutch gYnaecological Practice
Status: RECRUITING
Conditions: Ovarian Tumor|Ovarian Cancer
Interventions: OTHER: Observational study. Prospective registration of ultrasound data in patients with ovarian tumors for which an ultrasound in according with the IOTA definitions is performed.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Procalcitonin Level and the High Risk of Mortality in 30 Days in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Patient , Cases Series.
Status: COMPLETED
Conditions: the Relationship Between Procalcitonin and 30-day Mortality in COVID Patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety and Pharmacokinetics Study of ZB004 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: ZB004|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of an Investigational Zoster Vaccine in Subjects With a History of Varicella (Chickenpox) Given Concomitantly With Another Vaccine (V211-011)
Status: COMPLETED
Conditions: Herpes Zoster
Interventions: BIOLOGICAL: ZOSTAVAX™ (concomitant)|BIOLOGICAL: Comparator: Influenza Vaccine|BIOLOGICAL: ZOSTAVAX™ (Nonconcomitant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System
Status: TERMINATED
Conditions: Back Pain|Chronic Low Back Pain|Internal Disc Disruption|Degenerative Disc Disease
Interventions: BIOLOGICAL: BIOSTAT BIOLOGX|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TIPS Combined With Microwave Ablation in HCC Patients With Refractory Ascites
Status: UNKNOWN
Conditions: Liver Diseases|Portal Hypertension|Cirrhosis, Liver|Ascites|Hepatocellular Carcinoma
Interventions: PROCEDURE: Transjugular intrahepatic portosystemic shunt (TIPS)|PROCEDURE: microwave ablation (MWA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetic Testing for the Prevention of Cancer in Indigenous American Communities (JUNIPER Trial)
Status: NOT_YET_RECRUITING
Conditions: Hematopoietic and Lymphatic System Neoplasm|Malignant Solid Neoplasm
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Communication Intervention|OTHER: Genetic Testing|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Administration of DHEA in Patients With Poor Response to Ovarian Stimulation for IVF
Status: UNKNOWN
Conditions: Efficacy of DHEA|Pregnancy Rate|Diminished Ovarian Reserve|Changes in AMH
Interventions: DRUG: gonadotropins plus DHEA|DRUG: Gonadotropins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gabapentin Oral Solution in Decreasing Desflurane Associated Emergence Agitation
Status: UNKNOWN
Conditions: Emergence Agitation After Desflurane Anesthesia
Interventions: DRUG: Strawberry juice as (placebo)|DRUG: Gabapentin Oral Solution [Neurontin]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Relief by Intra-Peritoneal Ropivacaine During Gynecological Laparoscopy
Status: COMPLETED
Conditions: Laparoscopic Surgical Procedures
Interventions: DRUG: ropivacaine|DEVICE: Aeroneb Pro Nezulizer, Aerogen, Ireland
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sirolimus-eluting Stent CALYPSO vs Everolimus-eluting Stent XIENCE
Status: COMPLETED
Conditions: Ischemic Heart Disease|Coronary Atherosclerosis|Coronary Artery Disease|Coronary Artery Stenosis
Interventions: DEVICE: DES "Calypso"|DEVICE: DES "Xience Prime"|PROCEDURE: Coronary angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label, Single Center Phase 2 Study of Magrolimab, Rituximab and Radiation as Bridging Strategy Before CAR T-Cell Therapy in Patients With Relapsed or Refractory Large B-cell Lymphoma
Status: WITHDRAWN
Conditions: Large B-cell Lymphoma|B-cell Lymphoma
Interventions: DRUG: Magrolimab|DRUG: Rituximab|DRUG: CAR T leukapheresis|DRUG: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Qsymia as an Adjunct to Surgical Therapy in the Superobese
Status: COMPLETED
Conditions: Obesity|Metabolic Surgery|Weight Loss|Bariatric Surgery Procedures
Interventions: DRUG: Phentermine/topiramate|OTHER: low calorie diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nebivolol and Endothelial Regulation of Fibrinolysis (NERF)
Status: COMPLETED
Conditions: Prehypertension|Hypertension
Interventions: DRUG: Nebivolol|DRUG: Metoprolol|DRUG: Placebo|OTHER: Bradykinin|OTHER: Saline|OTHER: Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Attenuating Effect of Soluble Fiber Consumption on Postprandial Glycemia in Humans
Status: COMPLETED
Conditions: Postprandial Hyperglycemia|Type2 Diabetes|Blood Sugar; High
Interventions: OTHER: Control|OTHER: Isomaltodextrin Low Dose|OTHER: Isomaltodextrin High Dose|OTHER: GPC partially digestible maltodextrin|OTHER: Resistant Starch Type 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tislelizumab Consolidation Therapy After Radiotherapy or Sequential Chemoradiation in Locally Advanced NSCLC Patients
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer|Consolidation Immunotherapy|Radiotherapy or Sequential Chemoradiation
Interventions: DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Clinical Significance of Molecular Detection of Breast Cancer in the Blood of Stage IV Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: OTHER: Blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Alisertib in Treating Young Patients With Recurrent or Refractory Solid Tumors or Leukemia
Status: COMPLETED
Conditions: Hepatoblastoma|Previously Treated Childhood Rhabdomyosarcoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Kidney Neoplasm|Recurrent Childhood Malignant Germ Cell Tumor|Recurrent Childhood Rhabdomyosarcoma|Recurrent Childhood Soft Tissue Sarcoma|Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Recurrent Neuroblastoma|Recurrent Osteosarcoma
Interventions: DRUG: Alisertib|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tonsillectomy Using BiZact™ - a Randomized Side-controlled Clinical Trial
Status: COMPLETED
Conditions: Tonsillitis Chronic|Tonsillectomy|Hemorrhage|Postoperative Pain|Postoperative Hemorrhage|Surgery--Complications|Handling|Otorhinolaryngologic Diseases
Interventions: DEVICE: BiZactTM Open Sealer/Divider
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination 5-azacitidine and Gemtuzumab Ozogamicin Therapy for Treatment of Relapsed Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: 5-Azacitidine|DRUG: Gemtuzumab ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Behavior Change Communications and Market-based Approach to Delivering Micronutrient Powders on Stunting, Infant Feeding Practices and Anemia in Bangladesh
Status: COMPLETED
Conditions: Child Malnutrition|Breastfeeding|Complementary Feeding|Childhood Anemia
Interventions: BEHAVIORAL: EHC + BCC|DIETARY_SUPPLEMENT: Micronutrient powders|BEHAVIORAL: Mass media
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Concurrent PET D2/D3 Receptor Imaging and fMRI Smoking Cue Reactivity in Smokers
Status: WITHDRAWN
Conditions: Nicotine Dependence|Smoking Cue Reactivity|Relapse to Smoking
Interventions: RADIATION: [11C]-PHNO
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Non-Invasive Distractor During Knee Arthroscopy
Status: NOT_YET_RECRUITING
Conditions: Knee Arthritis|Knee Arthropathy
Interventions: DEVICE: Non-Invasive Knee Joint Distraction|PROCEDURE: Manual Joint Distraction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Magnetocardiography (MCG) Parameters in the Prediction of Future ICD Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Death, Sudden, Cardiac|Ventricular Arrythmia
Interventions: DEVICE: Magnetocardiogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Long-term Observation of PAP-therapy With Telemonitoring: Telemedicine Registry TelePAP
Status: ACTIVE_NOT_RECRUITING
Conditions: Obstructive Sleep Apnea|Central Sleep Apnea|Mixed Sleep Apnea
Interventions: OTHER: PAP therapy with telemonitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of STA-9090, Administered Twice-Weekly in Patients With Solid Tumors
Status: UNKNOWN
Conditions: Solid Tumors
Interventions: DRUG: STA 9090 (ganetespib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Repotrectinib in Combination With Chemotherapy in Children and Young Adults With Solid Tumor Cancer
Status: RECRUITING
Conditions: Advanced Cancer|Metastatic Solid Tumor
Interventions: DRUG: Repotrectinib|DRUG: Irinotecan and temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Renal Impairment on the Pharmacokinetics of NN9535
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2|Renal Impairment
Interventions: DRUG: semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Temporomandibular Disorders
Status: COMPLETED
Conditions: Temporomandibular Joint Disorders
Interventions: DEVICE: Transcutaneous electrical nerve stimulation|OTHER: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Benefit Provided by Sessions of Sophrology on the Per Operative Management of Parkinsonian Patients Planned for a Deep Brain Stimulation Surgery.
Status: TERMINATED
Conditions: Parkinson Disease|Deep Brain Stimulation
Interventions: BEHAVIORAL: sessions of sophrology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Pharmacokinetics Study of XOMA 052 in Subjects With Active, Stable, Moderate to Severe Rheumatoid Arthritis
Status: SUSPENDED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: XOMA 052|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Follow-up of Families in Early Preventive Intervention
Status: COMPLETED
Conditions: Child Rearing|Adolescent Development|Reproductive Behavior|Risk Reduction Behavior
Interventions: BEHAVIORAL: nurse home visitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Survival Of Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Salmeterol 50mcg/ Fluticasone Propionate 500mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Ureteric Dissection vs Preoperative Ureteric Stenting in Women With Abnormally Invasive Placenta
Status: UNKNOWN
Conditions: Placenta Accreta
Interventions: PROCEDURE: Ureteric dissection|PROCEDURE: Preoperative ureteric stenting|PROCEDURE: Cesarean hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CONTECI Program: A New Way to Control Peripheral Arterial Disease Using New Technologies
Status: COMPLETED
Conditions: Peripheral Arterial Disease|Personal Satisfaction|Telemedicine
Interventions: OTHER: Selfmanage with the help of telemedicine program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 1/2a Study of Belantamab Mafodotin in Relapsed or Refractory AL Amyloidosis
Status: RECRUITING
Conditions: AL Amyloidosis|Amyloidosis
Interventions: DRUG: Belantamab mafodotin 2.5 mg/kg (8 weeks)|DRUG: Belantamab mafodotin 1.9 mg/kg (8 weeks)|DRUG: Belantamab mafodotin 1.4 mg/kg (12 weeks)|DRUG: Belantamab mafodotin 1.9 mg/kg (12 weeks)|DRUG: Belantamab mafodotin every 4 weeks, 6 weeks,8 weeks, or 12 weeks as determined by Part 1 recommended dosages|DRUG: Belantamab mafodotin 1.0 mg/kg (12 weeks)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)|DRUG: Rivaroxaban-Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Injection Treatment of Corticosteroid to Pelvic Ligament Insertions on Women With Longlasting Backpain After Pregnancy
Status: COMPLETED
Conditions: Back Pain
Interventions: DRUG: Triamcinolone|DRUG: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dual FSH/HCG Trigger in Letrozole Stimulated Intrauterine Insemination Cycles in Women With Unexplained Infertility
Status: COMPLETED
Conditions: Unexplained Infertility
Interventions: DRUG: Human chorionic gonadotropin|DRUG: FSH co-trigger|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Efficacy and Safety Study of Ranibizumab 10mg/ml Injection (Incepta) in Patients With Diabetic Macular Edema
Status: RECRUITING
Conditions: Diabetic Macular Edema|Diabetic Retinopathy|Macular Edema|Macular Degeneration|Retinal Disease|Retinal Degeneration
Interventions: DRUG: Ranibizumab 10mg/ml Injection|DRUG: Lucentis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relaxation, Depressive Symptoms, Quality of Life in People Living With HIV: a Pilot Study
Status: COMPLETED
Conditions: HIV|Depressive Symptoms
Interventions: BEHAVIORAL: Jacobson progressive muscular relaxation|BEHAVIORAL: Schultz's autogenic training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Balcinrenone
Status: RECRUITING
Conditions: Hepatic Impairment
Interventions: DRUG: Balcinrenone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics/Dynamics of Basal (Continuous) Insulin Infusion Administered Either Intradermally or Subcutaneously
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DEVICE: Intradermal insulin delivery: BD Research Catheter Set|DEVICE: Subcutaneous insulin delivery:ACCU-CHEK Rapid-D Infusion Set
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Evaluating the Safety and Efficacy of KTE-C19 in Adult Participants With Refractory Aggressive Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Refractory Diffuse Large B Cell Lymphoma (DLBCL)|Relapsed Diffuse Large B-Cell Lymphoma|Transformed Follicular Lymphoma (TFL)|Primary Mediastinal B-cell Lymphoma (PMBCL)|High Grade B-cell Lymphoma (HGBCL)
Interventions: BIOLOGICAL: Axicabtagene Ciloleucel|DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Levetiracetam|DRUG: Tocilizumab|DRUG: Dexamethasone|DRUG: High-dose methylprednisolone|DRUG: Bendamustine|DRUG: Rituximab|DRUG: Doxorubicin|DRUG: Prednisone|DRUG: Vincristine|DRUG: Ifosfamide|DRUG: Carboplatin|DRUG: Etoposide|DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Cisplatin|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Subcutaneous (SC) Tocilizumab (RoActemra/Actemra) in Participants With Active Rheumatoid Arthritis (RA) and Inadequate Response to Disease-Modifying Anti-Rheumatic Drugs (DMARDs)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tocilizumab|DRUG: Methotrexate|DRUG: Non-Biologic DMARDs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Telbivudine Versus Lamivudine on the Early Dynamics and Kinetics of Viral Suppression in Chronic Hepatitis B
Status: WITHDRAWN
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Lamivudine|DRUG: Telbivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability & Potential Anti-cancer Activity of Increasing Doses of AZD5363 in Different Treatment Schedules
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Malignancy|Safety and Tolerability|Pharmacokinetics|Pharmacodynamics|Tumour Response|Advanced or Metastatic Breast Cancer|Ovarian Cancer|Cervical Cancer|Endometrial Cancer|PIK3CA|AKT1|PTEN|ER Positive|HER2 Positive
Interventions: DRUG: AZD5363|DRUG: AZD5363|DRUG: AZD5363|DRUG: AZD5363
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Smartlipo Triplex 1440nm Wavelength Laser and the Sidelaze 800 Hand Piece for the Treatment of Facial Acne Scars
Status: COMPLETED
Conditions: Acne Scars
Interventions: DEVICE: SmartLipo Triplex laser system along with the SideLaze800 hand piece
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutrient-Dense Complementary Foods on Catch-up Growth and Nutritional Status of Stunting Children
Status: UNKNOWN
Conditions: Stunting
Interventions: DIETARY_SUPPLEMENT: Nutrient dense complementary foods
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nalbuphine ER Effects of Liver Disease on Pharmacokinetics and Itch
Status: UNKNOWN
Conditions: Nalbuphine|Hepatic Impairment
Interventions: DRUG: Nalbuphine ER|DRUG: Nalbuphine ER -
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Whole-body Electromyostimulation and Dietary Supplements on "Sarcopenic Obesity"
Status: COMPLETED
Conditions: Sarcopenic Obesity
Interventions: BEHAVIORAL: WB-EMS Intervention|BEHAVIORAL: WB-EMS-Intervention and dietary supplementation|OTHER: control (dietary counseling)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study in Boys With Duchenne Muscular Dystrophy
Status: COMPLETED
Conditions: Muscular Dystrophy, Duchenne
Interventions: DRUG: Edasalonexent|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of EndoBarrier in Subjects With Type 2 Diabetes Who Are Obese
Status: TERMINATED
Conditions: Type 2 Diabetes|Obesity
Interventions: DEVICE: EndoBarrier|PROCEDURE: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Osteocalcin Level in Gingival Clavicular Fluid During Canine Retraction in Periodontal Compromised Patients
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: DIAGNOSTIC_TEST: measure Osteocalcin level
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vasculitis Illness Perception (VIP) Study
Status: COMPLETED
Conditions: Wegener Granulomatosis|Microscopic Polyangiitis|Churg-Strauss Syndrome|Polyarteritis Nodosa|Giant Cell Arteritis|Takayasu's Arteritis|Henoch-Schoenlein Purpura|Behcet's Disease|CNS Vasculitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Rate of Space Closure With Piezocision-based Corticotomy in Different Facial Types: A Split-mouth Design
Status: COMPLETED
Conditions: Class II Div 1 Malocclusion
Interventions: PROCEDURE: Piezocision Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Safety and Efficacy of Novel Combination Regimens for Treatment of Onchocerciasis
Status: ENROLLING_BY_INVITATION
Conditions: Onchocercal Subcutaneous Nodule|Onchocerciasis|Onchocerciasis, Ocular|Onchocerca Infection|Tropical Disease
Interventions: DRUG: Ivermectin w/ Albendazole|DRUG: Ivermectin + Diethylcarbamazine + Albendazole|DRUG: Moxidectin + Albendazole|DRUG: Moxidectin + Diethylcarbamazine + Albendazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Doppler or Amniocentesis to Predict Fetal Anemia
Status: COMPLETED
Conditions: Rh Isoimmunization
Interventions: PROCEDURE: Fetal Middle Cerebral Artery Doppler measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: This Study Combines Data From 3 Other Studies Testing Empagliflozin in Patients With Diabetes or With Chronic Heart Failure. The Study Looks at the Numbers of Patients Who Had Lower Limb Amputations
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo|DRUG: Empagliflozin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sodium-restricted Diets and Symptoms in End Stage Renal Disease: An RCT
Status: COMPLETED
Conditions: ESRD
Interventions: DIETARY_SUPPLEMENT: Sodium Restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treating Donors With Intravenous Immunoglobulin to Reduce Donor-Derived Infections
Status: NOT_YET_RECRUITING
Conditions: Viremia|Bacteremia|Acute Rejection of Renal Transplant
Interventions: DRUG: IVIG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of EPA and HMB on Strength in ICU Patients
Status: COMPLETED
Conditions: Muscle Weakness
Interventions: DRUG: HMB, hydroxymethylbutyrate|DRUG: EPA, eicosapentaenoic acid|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial of Five Fraction Partial Breast Irradiation (RAPID2)
Status: RECRUITING
Conditions: Breast Neoplasm Female|Radiotherapy|Cosmetic Outcome
Interventions: RADIATION: Whole Breast Irradiation (WBI)|RADIATION: Partial Breast Irradiation (PBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy for Cancer Related Fatigue in Patients With Metastatic Cancers
Status: RECRUITING
Conditions: Metastatic Cancers|Fatigue
Interventions: BEHAVIORAL: Psychoeducational Intervention|DRUG: Open Label Placebo|BEHAVIORAL: Psychoeducational Intervention+Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Two Different Doses of Rabbit ATG-Fresenius With Cyclosporin in the Treatment of Acquired Aplastic Anaemia
Status: UNKNOWN
Conditions: Aplastic Anemia
Interventions: DRUG: ATG-fresenius
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Structured Individiual Reminiscence on Self Transcendence of Palliative Care Patients
Status: RECRUITING
Conditions: Palliative Care
Interventions: OTHER: structured individual reminiscence|OTHER: unstructured social interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment With Sandostatin in Patients With Castrate Resistance Prostate Cancer Showing Uptake of 68Ga-DOTATET
Status: UNKNOWN
Conditions: Prostatic Neoplasms
Interventions: DRUG: Somatostatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AI-powered ECG Analysis Using Willem™ Software in High-risk Cardiac Patients (WILLEM)
Status: RECRUITING
Conditions: Cardiomyopathies|Cardiac Arrest|Cardiac Arrhythmias|Sudden Cardiac Death
Interventions: DIAGNOSTIC_TEST: AI-powered ECG analysis to detect cardiac arrhythmic episodes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sleep Disorders and Their Cardiovascular Correlates in Atahualpa.
Status: COMPLETED
Conditions: Insomnia|Hypersomnia|Sleep-disordered Breathing|Stroke|Ischemic Heart Disease
Interventions: OTHER: diagnostic test|OTHER: Diagnostic test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Babies Born Early Antibody Response to Men B Vaccination: BEAR Men B
Status: COMPLETED
Conditions: Prematurity|Vaccination|Meningococcal Disease
Interventions: BIOLOGICAL: 4CMenB Vaccine|BIOLOGICAL: 4CMenB Vaccine|BIOLOGICAL: 4CMenB Vaccine|BIOLOGICAL: 4CMenB Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Role of 68-Gallium-DOTATATE-PET/CT in the Imaging of Metastatic Thyroid Cancer
Status: RECRUITING
Conditions: Metastic Thyroid Cancer
Interventions: DRUG: 68-Gallium-DOTATATE-PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Investigation of Heylo, a Novel App Driven Digital Supporting Ostomy Product
Status: COMPLETED
Conditions: Ileostomy - Stoma|Colostomy Stoma
Interventions: DEVICE: Heylo|DEVICE: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of ME3183 in Subjects With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: ME3183|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Cancer on Memory Functioning: Understanding Disorders Using Approaches in Neuropsychology and Neuroimaging
Status: TERMINATED
Conditions: Breast Cancer|Healthy
Interventions: PROCEDURE: cognitive tests and cerebral IRM|PROCEDURE: cognitive tests and cerebral IRM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A 12-week Treatment, Multi-center, Randomized, Double-blind, Parallel-group, Placebo and Active Controlled Study to Assess the Efficacy, Safety, and Tolerability of Indacaterol Maleate / Glycopyrronium Bromide in COPD Patients With Moderate to Severe Airflow Limitation
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: QVA149|DRUG: QAB149|DRUG: NVA237|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tissue Analysis After Tumor Ablation for Liver Metastases Leading to Immediate Retreatment
Status: RECRUITING
Conditions: Liver Metastases
Interventions: DIAGNOSTIC_TEST: [18-F]- FDG - PET|PROCEDURE: Tumor ablation (TA)|DIAGNOSTIC_TEST: PET/CT Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Aloe Vera Mouthwashes on the Oral Health of Children
Status: COMPLETED
Conditions: Oral Health
Interventions: DRUG: Aloe Vera mouthwash|DRUG: Chlorhexidine mouthwash|DRUG: Placebo mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Patients With Pulmonary Hypertension or Interstitial Lung Disease at Altitude - Effect of Oxygen on Breathing and Sleep
Status: UNKNOWN
Conditions: Precapillary Pulmonary Hypertension|Interstitial Lung Disease
Interventions: BEHAVIORAL: Moderate altitude sojourn|BEHAVIORAL: Low altitude sojourn|DRUG: Oxygen|DRUG: Sham oxygen (room air)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Family Model DSME in FBOs in the RMI
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Family Model Diabetes Self-Management Education and Support|BEHAVIORAL: Family Model Diabetes Self-Management Education and Support (Wait-list)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Transdermal Patch CVD 2000: The Effect of Heat on Fentanyl Release From Fentanyl TDSs in Healthy Adults
Status: COMPLETED
Conditions: Peer Review, Research
Interventions: DRUG: Duragesic reference fentanyl TDS|DRUG: Apotex generic fentanyl TDS|DRUG: Mylan generic fentanyl TDS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH