pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Effects of Inspiratory Muscle Training on Endurance Performance in Trained Athletes Under Normoxic and Hypoxic Conditions: A Gender-based Comprehensive Study
Status: NOT_YET_RECRUITING
Conditions: Hypoxia, Altitude
Interventions: PROCEDURE: Inspiratory Muscle Training (IMT)|PROCEDURE: Normal Breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Tolerability and Efficacy of AKST1210 in Patients on Hemodialysis With Cognitive Impairment
Status: COMPLETED
Conditions: Cognitive Impairment|End Stage Renal Disease
Interventions: DEVICE: AKST1210|OTHER: Sham Control (No Intervention)|PROCEDURE: Hemodialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-parotid Facial Nerve Imaging in Parotidectomy
Status: COMPLETED
Conditions: Parotid Tumors|Facial Nerve Paresis
Interventions: DIAGNOSTIC_TEST: 3D-DESS MRI (3 dimensional double echo steady state MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Diaphragm Ultrasound to Predict Weaning Outcomes in Mechanically Ventilated Patients
Status: COMPLETED
Conditions: Accuracy of DE and DTF in Prediction of Extubation Success
Interventions: DIAGNOSTIC_TEST: comparaison between DE and DTF in prediction of extubation success
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Low-dose Chemotherapy Under Hypoglycaemia for the Treatment of Relapsed Refractory Advanced Solid Tumours
Status: RECRUITING
Conditions: Solid Tumors, Adult
Interventions: OTHER: Blood glucose stress combined with low-dose chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating BOSCC and ELSA as Outcome Measures in the Context of a JASPER Intervention Trial
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: clinician-mediated JASPER|BEHAVIORAL: parent-mediated JASPER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Absolute Bioavailability Study With Ipragliflozin
Status: COMPLETED
Conditions: Bioavailability of Ipragliflozin|Healthy Subjects
Interventions: DRUG: Ipragliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Paclitaxel Combined With Fluorouracil-Uracil and Leucovorin in Treating Patients With Solid Tumors
Status: WITHDRAWN
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: leucovorin calcium|DRUG: paclitaxel|DRUG: tegafur-uracil
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Somatostatin in Living Donor Liver Transplantation
Status: UNKNOWN
Conditions: End Stage Liver DIsease|Portal Hypertension
Interventions: DRUG: Somatostatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sequenced Treatment Alternatives to Relieve Depression (STAR*D)
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: citalopram|DRUG: BuproprionSR|DRUG: buspirone|DRUG: Lithium|DRUG: mirtazapine|DRUG: nortriptyline|DRUG: sertraline|DRUG: tranylcypromine|DRUG: VenlafaxineXR|BEHAVIORAL: Cognitive Therapy|DRUG: T3 (Triiodothyronine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MK-2206+Endocrine Therapy in Patients With Hormone Receptor-Positive Breast Cancer
Status: WITHDRAWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: MSK-2206|DRUG: Exemestane|DRUG: Goserelin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REACT MCI - Repeated Advanced Cognitive Training in Mild Cognitive Impairment
Status: RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: OTHER: Computerized cognitive training.|OTHER: Generalized brain training / Active control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Reuteri Feasibility Study on Probiotic Treatment and Perinatal Microbiome
Status: COMPLETED
Conditions: Pregnancy
Interventions: DRUG: Probiotic lozenges|DRUG: Placebo lozenges|DRUG: Probiotic capsules|DRUG: Placebo capsules|DRUG: Probiotic chewing gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of a Strategy Guided by Imaging Versus Systematic Coronary Angiography in Elderly Patients With Ischemia
Status: RECRUITING
Conditions: Myocardial Infarction
Interventions: OTHER: Stress single photon emission CT (SPECT) or Stress ultrasound with dobutamine (DSE)|PROCEDURE: Cornorary angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Maintenance Subcutaneous Rituximab With Observation Only in Participants With Relapsed or Refractory Indolent Non-Hodgkin's Lymphoma Who Had Responded to Rituximab-based Immunochemotherapy Induction and 2-year Maintenance With Subcutaneous Rituximab
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Chemotherapy (Induction Period)|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Ghana Primary Tube Versus Trabeculectomy Study
Status: UNKNOWN
Conditions: Glaucoma
Interventions: DEVICE: Aurolab glaucoma drainage device|PROCEDURE: Trabeculectomy with mitomycin-c
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Urinary Biomarker Study With Sulindac and Difluoromethylornithine
Status: WITHDRAWN
Conditions: Focus of Study: Drug Response Biomarkers, Chemoprevention, Neoplasms
Interventions: DRUG: difluoromethylornithine|DRUG: Sulindac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hepatocellular Carcinoma (HCC) Transarterial Chemoembolisation (TACE) +Axitinib
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet-rich Plasma for Chronic Lateral Ankle Instability
Status: COMPLETED
Conditions: Ankle Instability|Platelet-rich Plasma
Interventions: OTHER: Platelet-rich plasma|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: INJECT: A Pilot Study of Intra-tumoral Injections in Metastatic Urological Cancers
Status: COMPLETED
Conditions: Metastatic Castration-resistant Prostate Cancer (mCRPC)|Metastatic Urothelial Carcinoma|Metastatic Renal Cell Carcinoma
Interventions: DRUG: Isovue-M 200
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effectiveness of Educational Program on Parenting Stress and Coping Mechanism Among Parents of Children With Autism Spectrum Disorder in Amman, Jordan
Status: UNKNOWN
Conditions: Autism Spectrum Disorder
Interventions: OTHER: Educational program on parenting stress and coping mechanism
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Budesonide Via Delayed Release vs Immediate Release
Status: WITHDRAWN
Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: DRUG: Budesonide|DEVICE: Mucosal Atomization Device|DEVICE: NeilMed squeeze bottle for Impregnated Nasal Saline Irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Integrated Brain, Body and Social Intervention for Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: BEHAVIORAL: IBBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral Semaglutide Versus Empagliflozin in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: semaglutide|DRUG: empagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pregabalin for Treatment of Patients With Postherpetic Neuralgia (PHN)
Status: COMPLETED
Conditions: Postherpetic Neuralgia ( PHN )
Interventions: DRUG: Lyrica (pregabalin)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Response to Kuvan® in Subjects With Phenylketonuria (PKU) in a 4 Weeks Testing Period
Status: COMPLETED
Conditions: Phenylketonuria
Interventions: DRUG: Kuvan®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic (PK) Bioequivalence and Pharmacodynamics (PD) of Julphar Insulin N and Huminsulin® Basal
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Julphar Insulin N (human isophane insulin)|DRUG: Huminsulin® Basal (NPH, human isophane insulin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of TTFields (150 kHz) Concomitant With Pemetrexed and Cisplatin or Carboplatin in Malignant Pleural Mesothelioma (STELLAR)
Status: COMPLETED
Conditions: Malignant Pleural Mesothelioma
Interventions: DEVICE: NovoTTF-100L device|DRUG: Pemetrexed|DRUG: Cisplatin or Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Telehealth Lifestyle Management Program to Improve Healthy Behaviors Post Head Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: Lifestyle|BEHAVIORAL: Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Patients With Erosive Esophagitis to Investigate Safety, Tolerability, and Healing Rates After 4 Weeks Treatment of X842 or Lansoprazole and Symptom Pattern During Subsequent 4 Weeks Treatment With Lansoprazole
Status: COMPLETED
Conditions: Erosive Esophagitis
Interventions: DRUG: X842|DRUG: X842 Dummy|DRUG: Lansoprazole|DRUG: Lansoprazole Dummy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability of Valproic Acid in Trauma Patients(Part 2)
Status: TERMINATED
Conditions: Shock,Hemorrhagic|Trauma
Interventions: DRUG: Valproic Acid|DRUG: Isotonic saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Begin With The Right Patients With Dual-Inhibition Action Therapy Through Vytorin for Newly Diagnosed Dyslipidemia Patients (0653A-172)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: ezetimibe (+) simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tumescent Lidocaine Maximum Safe mg/kg Dosage
Status: UNKNOWN
Conditions: Anesthesia
Interventions: DRUG: Tumescent Local Anesthesia (lidocaine, epinephrine)|PROCEDURE: Liposuction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Biliary Co-axial Stent Placement Plus/Minus Use of Radiofrequency Ablation (RFA) for Clearance of Occluded Self Expandable Metal Stents (SEMS) in Patients With Distal Biliary Obstruction From Unresectable Biliary-pancreatic Malignancies
Status: COMPLETED
Conditions: Pancreatic Cancer|Unresectable Biliary-pancreatic Malignancies
Interventions: DEVICE: ERCP with SEMS plus radiofrequency ablation|DEVICE: ERCP with SEMS alone (standard of care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combining N-of-1 Trials to Assess Fibromyalgia Treatments
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: Amitriptyline|DRUG: Amitriptyline plus Fluoxitine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyalornic Acid Level in β-Thalassemic Children Treated for Hepatitis C Virus
Status: COMPLETED
Conditions: Beta-Thalassemia|Hepatitis C
Interventions: DRUG: Ledipasvir 90 MG / Sofosbuvir 400 MG [Harvoni]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prucalopride and Cognition in Recovered Depression
Status: COMPLETED
Conditions: Depression in Remission
Interventions: DRUG: Prucalopride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Dose Escalating Study With BAY43-9006 With Carboplatin, Paclitaxel and Bevacizumab in Untreated Stage IIIb Non-small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung|Lung Cancer
Interventions: DRUG: Nexavar (Sorafenib, BAY43-9006)|DRUG: Nexavar (Sorafenib, BAY43-9006)|DRUG: Bevacizumab|DRUG: Bevacizumab|DRUG: Bevacizumab|DRUG: Bevacizumab|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Imaging of Joint Replacement Complications by PET/CT
Status: COMPLETED
Conditions: Adverse Reactions to Metal Debris|Infection of Total Hip Joint Prosthesis|Mechanical Loosening of Prosthetic Joint
Interventions: DIAGNOSTIC_TEST: 68Ga-citrate and 18F-FDG PET/CT imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Penicillin Allergy Delabeling After a One-Dose Versus Two-Dose Graded Direct Oral Challenge
Status: RECRUITING
Conditions: Penicillin Allergy
Interventions: DRUG: Amoxicillin 250 MG|DRUG: Placebo|DRUG: Amoxicillin 62.5mg|DRUG: Amoxicillin 187.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Using a Mouthwash Containing Propolis, Clove Oil and Chlorhexidine to Improve the Caries Risk of High Risk Patients
Status: COMPLETED
Conditions: Caries, Dental|Risk Reduction
Interventions: OTHER: Chlorhexidine, Propolis and Clove Oil mouthwash|OTHER: Chlorhexidine mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Personalized Repetitive Transcranial Magnetic Stimulation Treatment for Major Depressive Episode
Status: RECRUITING
Conditions: Major Depressive Episode
Interventions: DEVICE: Active rTMS|DEVICE: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glibentek in Patients With Neonatal Diabetes Secondary to Mutations in K+-ATP Channels
Status: COMPLETED
Conditions: Neonatal Diabetes Secondary to Mutation in the Potassium Channel
Interventions: DRUG: Glibenclamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effect of Preoperative Dexamethasone in Gynecological Laparotomies - a Dose-ranging Study
Status: COMPLETED
Conditions: Postoperative Pain|Postoperative Nausea and Vomiting|Fatigue
Interventions: DRUG: Dexamethasone (0.1 mg/kg)|DRUG: Dexamethasone (0.2 mg/kg)|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Surgical Outcomes of the Accelerometer-based Navigation System for Total Knee Arthroplasty
Status: RECRUITING
Conditions: Arthroplasty; Replacement; Knee|Radiotherapy; Image-Guided
Interventions: DEVICE: KneeAlign 2 system (OrthAlign Inc, Aliso Viejo, California)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Guardcontrol Trial: Study to Assess if Type 1 Diabetics Can Improve Using the Real-time Values of Guardian RT
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: Guardian RT|DEVICE: SMBG only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Usefulness of ICG Angiography-Guided Thyroidectomy for Preserving Parathyroid Function
Status: RECRUITING
Conditions: Iatrogenic Hypocalcemia
Interventions: PROCEDURE: ICG angiography to show vascular map of parathyroid glands
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Heart Rate Reduction in Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: ivabradine|DRUG: "Drug:Carvedilol" and "Drug:Ivabradine"|DRUG: Carvedilol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Bupivacaine in Shoulder Arthroscopy
Status: WITHDRAWN
Conditions: Rotator Cuff Tears
Interventions: DRUG: Liposomal bupivacaine|DRUG: Bupivacaine with Dexamethasone Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Salivary Drug Concentration Exploratory Study of Cetylpyridinium Chloride Buccal Tablets
Status: COMPLETED
Conditions: Pharyngitis Acute|Gingivitis
Interventions: DRUG: Cetylpyridinium Chloride Buccal Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ALKS 3831 in Adults With Schizophrenia (The ENLIGHTEN-2 Study)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: ALKS 3831|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Single-dose Bioavailability Clinical Study of Different Coenzyme Q10 Products
Status: COMPLETED
Conditions: Coenzyme Q Deficiency
Interventions: DIETARY_SUPPLEMENT: Dietary supplement - standard product|DIETARY_SUPPLEMENT: Dietary supplement - Investigational product IP1|DIETARY_SUPPLEMENT: Dietary supplement - Investigational product IP2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Safety Study of CNTO 2476 in Patients With Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Age-related Macular Degeneration
Interventions: BIOLOGICAL: CNTO 2476|PROCEDURE: iTrack Model 275 micro catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Fermented Barley on Decrement of Body Fat in Obese Subjects
Status: COMPLETED
Conditions: Overweight; Hyperlipidemia
Interventions: DIETARY_SUPPLEMENT: Barley beta-glucan(3.0g)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Validation of PUFA Index in Assessing Untreated Dental Caries Among Malaysian Adult Subpopulation
Status: COMPLETED
Conditions: Pulpitis|Apical Periodontitis
Interventions: DIAGNOSTIC_TEST: Screening using DMFT and PUFA, orthopantomogram is taken and assessed using PAI, comprehensive clinical examination to diagnose pulpal and periapical conditions.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Uncomplicated Skin and Soft Tissue Infections Caused by Community-Associated Methicillin-Resistant Staphylococcus Aureus
Status: COMPLETED
Conditions: Staphylococcal Infection
Interventions: DRUG: Trimethoprim-sulfamethoxazole|OTHER: Placebo|DRUG: Clindamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Response to Influenza Vaccination in Lymphoma Patients Treated With Rituximab
Status: COMPLETED
Conditions: Non-Hodgkin Lymphoma (NHL)
Interventions: BIOLOGICAL: influenza vaccination with influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Engaging in Advance Care Planning Talks (ENACT) Group Visits in Primary Care for Older Adults With and Without Alzheimer's Disease
Status: ENROLLING_BY_INVITATION
Conditions: Advance Care Planning|Primary Health Care
Interventions: BEHAVIORAL: ENACT group visit|BEHAVIORAL: Mailed Resources
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cardiopulmonary Exercise Testing and Preoperative Risk Stratification
Status: COMPLETED
Conditions: Colorectal Cancer|Anaesthesia|Critical Illness
Interventions: OTHER: Perioperative care pathway guided by CPX results
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Heat-not-burn Tobacco Product to Aid in Switching From Combustible to Noncombustible Nicotine (IQOS)
Status: TERMINATED
Conditions: Smoking Behaviors
Interventions: OTHER: IQOS|OTHER: Smoking as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Treatment of Intermittent Claudication by G-CSF-mobilized PB-MNC
Status: UNKNOWN
Conditions: Intermittent Claudication|PAD|Atherosclerotic Ischemic Disease
Interventions: PROCEDURE: PB-MNC therapy|DRUG: No PB-MNC therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Triathlon - A New Total Knee Prosthesis System - Roentgen Stereophotogrammetric Analysis (RSA) Triathlon CR vs. PS
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee
Interventions: DEVICE: Triathlon CR|DEVICE: Triathlon PS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lidocaine Compared to Magnesium Sulfate to Prolong Spinal Anesthesia: Non-inferiority Randomized Clinical Trial
Status: COMPLETED
Conditions: Anesthesia|Pain
Interventions: DRUG: Magnesium Sulfate|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa
Status: RECRUITING
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: Lutikizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Multi-Faceted Psychiatric Intervention Targeted at the Complex Medically Ill: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Diabetes
Interventions: BEHAVIORAL: Multi-faceted psychiatric intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Observational Patient Registry of the Dynamic Locking Screws
Status: WITHDRAWN
Conditions: Proximal or Diaphyseal Humerus Fracture|Diaphyseal or Distal Femur Fracture|Diaphyseal, Distal or Proximal Tibia Fracture
Interventions: DEVICE: Dynamic Locking Screw 3.7mm and 5.0mm
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Role of Exercise-Periodic-Breathing (EPB) in Impaired Ventilation Regulation Dysfunction in Heart Failure Patients
Status: COMPLETED
Conditions: Impaired Oxygen Delivery|Ischemic Reperfusion Injury
Interventions: BEHAVIORAL: exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment in Patients With Globus: Psychoeducation, Anxiolytics or Proton Pump Inhibitors
Status: COMPLETED
Conditions: Globus
Interventions: DRUG: Omeprazole|BEHAVIORAL: psychoeducation|DRUG: Flupentixol +Melitracen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protein Supplementation to Promote Muscle Protein Anabolism in Frail Elderly People
Status: COMPLETED
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Protein drink|DIETARY_SUPPLEMENT: Placebo drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nitric Oxide Inhalation Therapy for COVID-19 Infections in the ED
Status: TERMINATED
Conditions: COVID19
Interventions: DRUG: Nitric Oxide Gas|OTHER: Inhaled Supplemental Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: HTX-011|DRUG: Bupivacaine Hydrochloride|DRUG: Ibuprofen|DRUG: Acetaminophen|DEVICE: Luer lock applicator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra Versus Extra-thoracic Oscillations in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: High frequency extra thoracic oscillations vest|DEVICE: Intrathoracic oscillatory quake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Effects of Mesenchymal Stem Cell (MSCs) in the Treatment of Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: UC-MSCs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Opiate Suicide Study in Patients With Major Depression
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DRUG: Ketamine|DRUG: Buprenorphine|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cytoreductive Surgery and Intraperitoneal Chemotherapy for Stomach CAncer: a Feasibility Study
Status: TERMINATED
Conditions: Gastric Cancer|Peritoneal Carcinomatosis|HIPEC
Interventions: DRUG: Perioperative chemotherapy|PROCEDURE: Cytoreduction|DRUG: HIPEC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NGS Diagnostic in COVID-19 Hosts - Genetic Cause Relating to the Course of Disease Progression
Status: COMPLETED
Conditions: COVID-19
Interventions: GENETIC: Whole Genome Analysis|GENETIC: T-cell receptor (TCR) repertoire|GENETIC: SARS-CoV-2 viral composition
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination Chemotx in Treating Children or Adolescents With Newly Diagnosed Stg III or Stg IV Lymphoblastic Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: asparaginase|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: leucovorin calcium|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: prednisone|DRUG: thioguanine|DRUG: vincristine sulfate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Checkpoint Therapy vs Target Therapy in Reducing Serum HBsAg Levels in Patients With HBsAg+ Advanced Stage HCC
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Durvalumab|DRUG: Sorafenib|DRUG: Lenvatinib|DRUG: Regorafenib|DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Non Invasive Vagus Nerve Stimulation in Cerebral Palsy (BOOSTTVNS)
Status: NOT_YET_RECRUITING
Conditions: Cerebral Palsy
Interventions: DEVICE: transcutaneous vagus nerve stimulation (tVNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Accelerated Enhanced RECOVERy Following Minimally Invasive Colorectal Cancer Surgery (RecoverMI)
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BEHAVIORAL: Accelerated Recovery Plan|BEHAVIORAL: Early Discharge|OTHER: Telemedicine|BEHAVIORAL: Standard Enhanced Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Relative Bioavailability of Capsule and Tablet Formulations of GDC-0941 and the Effect of Food and Proton Pump Inhibition on GDC-0941 Tablet Pharmacokinetics in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: GDC-0941|DRUG: rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Efficacy of Saisei Pharma Dietary Supplements MAF Capsules, 148 mg and M Capsules, 148 mg in Hospitalized COVID-19 Patients
Status: COMPLETED
Conditions: Covid19
Interventions: DIETARY_SUPPLEMENT: MAF capsules 148 mg|DIETARY_SUPPLEMENT: M capsules 148 mg|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Surgical Conditions in Cesarean Section Under General Anesthesia With Deep Neuromuscular Blockade Versus Succinylcholine
Status: COMPLETED
Conditions: Cesarean Section
Interventions: DRUG: Rocuronium|DRUG: Succinylcholine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bergen Psychosis Project 2 - The Best Intro Study
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders
Interventions: DRUG: Amisulpride|DRUG: Aripiprazole|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Accommodative Responses of Soft Contact Lenses for Myopia Control
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: Test Lens 1|DEVICE: Test Lens 2|DEVICE: Test Lens 3|DEVICE: Test Lens 4|DEVICE: Test Lens 5|DEVICE: Control Lens 1|DEVICE: Control Lens 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Erector Spinae Plane Block Versus Rectus Sheath Block for Postoperative Analgesia After Supraumbilical Surgery
Status: RECRUITING
Conditions: Post Operative Pain
Interventions: PROCEDURE: Erector Spinae Plane Block (ESPB)|PROCEDURE: Rectus Sheath Block (RSB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Predictors of Postoperative Delirium After Transcatheter Aortic Valve Implantation
Status: COMPLETED
Conditions: Postoperative Delirium
Interventions: OTHER: Delirium assessment|OTHER: MMSE (Mini Mental State Examination)|OTHER: Barthel index|OTHER: HADS (Hospital Anxiety and Depression Scale)|OTHER: MNA-SF (Mini Nutritional Assessment - Short Form)|DEVICE: NIRS (Near-Infrared Spectroscopy)|OTHER: CIRS (Cumulative Illness Rating Scale)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ARTEMIS Synovial Markers in Arthritis Childhood
Status: COMPLETED
Conditions: Septic Arthritis|Juvenile Idiopathic Arthritis
Interventions: PROCEDURE: Articular punction, salivary samples, blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I/IIa Study of 68GaNOTA-Anti-MMR-VHH2 for PET/CT
Status: RECRUITING
Conditions: Malignant Solid Tumor|Breast Cancer|Melanoma (Skin)
Interventions: DRUG: 68GaNOTA-Anti-MMR-VHH2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: BaSES Trial: Basel Starch Evaluation in Sepsis
Status: COMPLETED
Conditions: Sepsis|Severe Sepsis|Septic Shock
Interventions: DRUG: hydroxy-ethyl starch (MW 130; 0.4) vs. normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Gallopamil in Severe Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Methoxyverapamil (gallopamil)|DRUG: Placebo.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Consolidation PET-based and Donor-based After Salvage Therapy in Patients With HL in Relapse or Refractory
Status: TERMINATED
Conditions: Hodgkin's Lymphoma
Interventions: OTHER: Patients with negative PET after salvage therapy|OTHER: Patients with positive PET after salvage therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Treatment IND (Investigational New Drug) Protocol for the Use of Videx (2',3'-Dideoxyinosine, ddI) in Patients With Acquired Immunodeficiency Syndrome (AIDS) or AIDS- Related Complex (ARC) Who Are Intolerant to Zidovudine (Retrovir)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Flywheel Exercise on Muscle and Walking Function in Teenagers and Young Adults With Cerebral Palsy
Status: WITHDRAWN
Conditions: Cerebral Palsy
Interventions: OTHER: Flywheel resistance exercise|OTHER: Weight-stack resistance exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Distal Perfusion Timing, Early or Conservative, to Prevent Limb Ischemia During Peripheral VA-ECMO
Status: RECRUITING
Conditions: Extracorporeal Membrane Oxygenation Complication
Interventions: PROCEDURE: Distal perfusion catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus|Critical Limb Ischemia|Lower Limb Amputation Knee|Peripheral Arterial Disease
Interventions: DRUG: Active Arm N-acetyl cysteine (NAC)|DRUG: Placebo Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pharmacodynamic and Genetic Parameters of Abira-DES Study Participants (NCT02217566) - Participants With Metastatic Castration-Resistant Prostate Cancer Treated With Abiraterone Acetate Following Unresponsive Treatment With Diethylstilbestrol
Status: COMPLETED
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: OTHER: Serum and plasma samples analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Efficacy of a Toothpaste That Reduces Plaque and Gingivitis
Status: COMPLETED
Conditions: Gingivitis
Interventions: DRUG: Triclosan, fluoride|DRUG: Fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MELD as an Adjunct for SEEG Trajectories
Status: UNKNOWN
Conditions: Epilepsy|Epilepsy, Focal|Epilepsy, Refractory
Interventions: PROCEDURE: MELD algorithm use to aid in the planning of SEEG electrode trajectories
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A SAD, MAD, and FE Study to Evaluate the Safety, Tolerability, and Pharmacokinetic Profile of FM101 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Single ascending doses of FM101|DRUG: Multiple ascending doses of FM101|DRUG: Food effects of FM101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chemoprevention of Gastric Carcinogenesis
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Cancer|Gastric Intestinal Metaplasia
Interventions: DRUG: Eflornithine|OTHER: Eflornithine placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Ferric Derisomaltose in Patients With Acute Heart Failure and Iron Deficiency on Exercise Capacity and Quality of Life
Status: RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction|Iron Deficiencies|Acute Heart Failure
Interventions: DRUG: Ferric derisomaltose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: KickStart30: A 30-Day Nursing Wellness Initiative
Status: COMPLETED
Conditions: Substance Use
Interventions: BEHAVIORAL: Wellness Element 1: Exercise|BEHAVIORAL: Wellness Element 2: Mindfulness|BEHAVIORAL: Wellness Element 3 - Sleep Hygiene|BEHAVIORAL: Wellness Element 4 - Social Connectedness|BEHAVIORAL: Wellness Element 5 - Nutrition|BEHAVIORAL: Wellness Element 6 - Wellness Exercises|BEHAVIORAL: Wellness Element 7 - Motivational Messages
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Cultura Yoghurt in Irritable Bowel Syndrome (IBS) Patients on Intestinal and Immunological Changes
Status: COMPLETED
Conditions: Irritable Bowel Syndrome|Relief of Irritable Bowel Syndrome Symptoms|Quality of Life
Interventions: OTHER: Arla Yoghurt with no probiotic|OTHER: Probiotic yoghurt (Cultura)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-articular Injection of MSCs in Treatment of Knee OA
Status: UNKNOWN
Conditions: Osteoarthritis|Stem Cells|MSC
Interventions: BIOLOGICAL: Placenta Derived Mesenchymal Stem Cell|DRUG: Sodium Hyaluronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endobiotics for Phenotyping of Human Cytochrome P450 Enzymes
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Dextromethorphan 5 MG|DRUG: Paroxetine 10Mg Tablet|DRUG: Paroxetine 20Mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Postoperative Hip Precautions After Total Hip Arthroplasty Via the Posterior Approach: A Prospective Randomized Trial
Status: RECRUITING
Conditions: Osteoarthritis|Degenerative Joint Disease
Interventions: OTHER: Hip Precautions|OTHER: No Hip Precautions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modified ABC: A Home-based Parenting Program for Opioid-dependent Mothers and Their Infants
Status: COMPLETED
Conditions: Opioid-Related Disorders|Parent-Child Relations|Infant Development|Parenting
Interventions: BEHAVIORAL: Modified Attachment and Biobehavioral Catch-up|BEHAVIORAL: Modified Developmental Education for Families
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Effects of CPAP and HHHFNC on Diaphragmatic Dimensions in Preterm Infants
Status: COMPLETED
Conditions: Respirtory Distress
Interventions: DEVICE: CPAP first (Fisher & Paykel Healthcare)|DEVICE: HHHFNC first (Fisher & Paykel Healthcare)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paracetamol (Acetaminophen) for Closure of PDA in Preterm Infants
Status: COMPLETED
Conditions: PDA
Interventions: DRUG: Paracetamol|DRUG: Ibuprofen|PROCEDURE: Closure of PDA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Probiotic Oral Intake on Plasma Chlordecone (Kepone) Concentrations in Individuals Environmentally Exposed to Pesticide in Martinique.
Status: NOT_YET_RECRUITING
Conditions: Chlordecone (Kepone) Toxicity
Interventions: DIETARY_SUPPLEMENT: Limosilactobacillus reuteri|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acalabrutinib, Venetoclax, and Obinutuzumab for Initial Therapy of CLL
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia (CLL)
Interventions: DRUG: Venetoclax|DRUG: Obinutuzumab|DRUG: Acalabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Valproic Acid Plus Cisplatin and Cetuximab in Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck
Status: ACTIVE_NOT_RECRUITING
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Valproic Acid|DRUG: Cisplatin|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine if Hyperbaric Oxygen Therapy is Helpful for Treating Radiation Tissue Injuries
Status: TERMINATED
Conditions: Radiation Injuries
Interventions: PROCEDURE: Hyperbaric Oxygen Therapy|PROCEDURE: Sham treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Trial Of Safety, Pharmacokinetic/Pharmacodynamic And Preliminary Clinical Activity of Briquilimab In Adult Patients With Chronic Spontaneous Urticaria (CSU)
Status: RECRUITING
Conditions: Chronic Spontaneous Urticaria
Interventions: DRUG: Briquilimab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnesium Supplementation for the Prevention of Supraventricular Arrhythmias
Status: COMPLETED
Conditions: Premature Atrial Contraction
Interventions: DRUG: Oral Magnesium Supplement|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acute Effects of High Intensity Interval Exercise on Executive Function
Status: COMPLETED
Conditions: High Intensity Interval Exercise (HIIE)|Pain Perception|Wisconsin Card Sorting Task
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: Cognitive Task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE