pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Cytokine and Growth Factor Changes and Correlation With Clinical Outcomes Following Acupuncture for TMD
Status: WITHDRAWN
Conditions: Temporomandibular Joint Disorders
Interventions: DEVICE: Acupuncture|DEVICE: Sham Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of E-mental Health Program and Job Coaching on the Risk of Major Depression in Canadian Working Men
Status: COMPLETED
Conditions: Depression|Men
Interventions: OTHER: e-mental health program|OTHER: e-mental health program and job coaching|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Omega-3 Supplements to Reduce Antisocial Behaviour in Young Offenders
Status: COMPLETED
Conditions: Antisocial Behavior
Interventions: COMBINATION_PRODUCT: Omega-3|COMBINATION_PRODUCT: Placebo|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability and Effects of Single and Multiple Ascending Doses of ASP1707 in Healthy Male and Pre-menopausal Female Subjects, Including a Comparison of the Effects Under Fasted and Fed Conditions in Healthy Young Male Subjects
Status: COMPLETED
Conditions: Pharmacokinetics of ASP1707|Pharmacodynamics of ASP1707
Interventions: DRUG: ASP1707 single dose of dose levels 1 -7|DRUG: Placebo single dose of dose levels 1-7|DRUG: ASP1707 single dose fasted|DRUG: ASP1707 single dose fed|DRUG: ASP1707 multiple dose of dose levels 1-4|DRUG: Placebo multiple dose of dose levels 1-4|DRUG: ASP1707 multiple dose of dose levels 1-2|DRUG: Placebo multiple dose of dose levels 1-2|DRUG: ASP1707 parallel multiple dose of dose levels 1-3|DRUG: Placebo parallel multiple dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery
Status: COMPLETED
Conditions: Analgesia, Obstetrical|Postpartum Hemorrhage|Opioid Use|Nonsteroidals (NSAIDs)Toxicity|Coagulation Defect; Postpartum|Postoperative Pain|Ketorolac Adverse Reaction|Blood Loss, Postoperative
Interventions: DRUG: Ketorolac|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerance and Effectiveness of Cell Therapy by Autologous Apoptotic Cells in the Treatment of Rheumatoid Arthritis
Status: NOT_YET_RECRUITING
Conditions: Arthritis, Rheumatoid
Interventions: BIOLOGICAL: Autologous apoptotic cells injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Oleic Acid on Inflammation Markers and Blood Lipid Metabolites: A Randomised, Double-Blind, Crossover Study
Status: COMPLETED
Conditions: Inflammation
Interventions: OTHER: Novel Olein|OTHER: Novel Olein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison Trial for Chloraprep Versus Aqueous Chlorhexidine (2%) for the Prevention of Catheter-related Bacteremia
Status: WITHDRAWN
Conditions: Sepsis Affecting Skin|Central Venous Catheter Related Bacteremia
Interventions: DRUG: A (Chloraprep)|DRUG: B (Clorhexidine 2%)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Physical Activity to Improve Patient Reported Outcomes for Adults With Acute Leukemia
Status: COMPLETED
Conditions: Physical Activity|Exercise|Acute Leukemia|Consolidation|Maintenance Therapy
Interventions: BEHAVIORAL: Build Stamina Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Topical Application of AS101 for the Treatment of Atopic Dermatitis
Status: TERMINATED
Conditions: Atopic Dermatitis
Interventions: DRUG: AS101 ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bortezomib, Rituximab and Dexamethasone (BORID) for Relapsed/Refractory Mantle Cell Lymphoma
Status: UNKNOWN
Conditions: Lymphoma, Mantle-Cell
Interventions: DRUG: bortezomib|DRUG: rituximab|DRUG: dexamethasone|PROCEDURE: treatment protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Novel Care Pathway in Women With "Low-risk" Gestational Diabetes Mellitus
Status: RECRUITING
Conditions: Gestational Diabetes Mellitus in Pregnancy
Interventions: OTHER: New Care Pathway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Radiation Therapy, Chemotherapy, and Cetuximab Followed by Surgery, Chemotherapy, and Cetuximab in Treating Patients With Locally Advanced or Metastatic Rectal Cancer That Can Be Removed by Surgery
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: capecitabine|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bicalutamide in Treatment of Androgen Receptor (AR) Positive Metastatic Triple Negative Breast Cancer
Status: TERMINATED
Conditions: Metastatic Triple Negative Breast Cancer
Interventions: DRUG: TPC|DRUG: Bicalutamide 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Initial Positioning of Left Sided Double Lumen Endobronchial Tubes Using Peak Inspiratory Pressures Difference Between Two Lungs
Status: COMPLETED
Conditions: Thoracic Surgery
Interventions: PROCEDURE: Pressure difference
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Role of the Immune Environment in Response to Therapy in Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|ER Positive Breast Cancer|HER2-negative Breast Cancer|TNBC - Triple-Negative Breast Cancer
Interventions: OTHER: Collection of personal health information from women treated at the University of Pennsylvania under an approved HIPAA waiver.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Relationship Between Pes Planus, Diaphragm, Postural Control, and Plantar Pressure
Status: RECRUITING
Conditions: Pes Planus|Diaphragm Issues|Plantar Pressure|Postural Control
Interventions: DIAGNOSTIC_TEST: Determination of Foot Deformity Level|DIAGNOSTIC_TEST: Foot Function Index|DIAGNOSTIC_TEST: UFAA-International Physical Activity Questionnaire|DIAGNOSTIC_TEST: Diaphragm ultrasound measurements|DIAGNOSTIC_TEST: NeuruCom Balance Master Balnce and Performans Test|DIAGNOSTIC_TEST: Plantar Pressure Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Remote Ischaemic Conditioning After Stroke Trial (ReCAST-2)
Status: COMPLETED
Conditions: Stroke
Interventions: PROCEDURE: Remote ischaemic conditioning|PROCEDURE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Hyaluronic Acid in Causing Cancer Stem Cell Growth in the Bones of Patients With Breast Cancer
Status: WITHDRAWN
Conditions: Breast Carcinoma Metastatic to the Bone|Stage IV Breast Cancer
Interventions: OTHER: Cytology Specimen Collection Procedure|OTHER: Laboratory Biomarker Analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Effectiveness of the CustomFlex Artificial Iris Prosthesis for the Treatment of Iris Defects
Status: RECRUITING
Conditions: Full Aniridia|Partial Aniridia
Interventions: DEVICE: Artificial Iris (CustomFlex)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Patient Outcomes and Safety and Effectiveness of Robotic Assisted Unicompartmental Knee Replacements Versus Conventional Unicompartmental Knee for Subjects With Primary Arthritis of the Knee Joint Involving One (UKA) Compartment (Medial or Lateral)
Status: SUSPENDED
Conditions: Arthroplasty, Replacement, Knee|Unicompartmental Knee Arthroplasty
Interventions: DEVICE: Robotic System|DEVICE: Conventional
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study of Mindfulness Training Transcranial Direct Current Stimulation (tDCS) in Adults With Overweight and Obesity
Status: NOT_YET_RECRUITING
Conditions: Adults With Overweight and Obesity
Interventions: COMBINATION_PRODUCT: Mindfulness training + real tDCS|COMBINATION_PRODUCT: Mindfulness training + sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Platinum-Based Chemotherapy With/Without INCMGA00012, an Anti-PD-1 Antibody, in Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Squamous Non-Small Cell Lung Cancer|Metastatic Nonsquamous Non-Small Cell Lung Cancer
Interventions: DRUG: Retifanlimab|DRUG: Placebo|DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: nab-Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a New Ebola Vaccine Using a Short-interval Prime-boost Vaccination
Status: COMPLETED
Conditions: Ebola Virus Disease
Interventions: BIOLOGICAL: ChAd3-EBO Z|BIOLOGICAL: MVA-EBO Z
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of the Herbst Appliance With Different Anchorages and Twin-Block Appliance in Class II Malocclusion
Status: RECRUITING
Conditions: Malocclusion, Angle Class II
Interventions: DEVICE: Herbst appliance with skeletal anchorage|DEVICE: Herbst appliance with dental anchorage|DEVICE: Twin-Block appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Promoting Safer Sex in HIV+ Homosexual and Bisexual Men Who Use Methamphetamine
Status: COMPLETED
Conditions: HIV Infections|STDs|Methamphetamine Abuse
Interventions: BEHAVIORAL: Theory-based counseling program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Investigation of the Effectiveness and Safety of MRZF111 in the Treatment of Décolleté Wrinkles
Status: COMPLETED
Conditions: Décolleté Wrinkles
Interventions: DEVICE: MRZF111
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Adrenergic Drugs on the Fluid Balance During Surgery
Status: COMPLETED
Conditions: Ovarian Cyst
Interventions: DRUG: Esmolol administration|DRUG: Phenylephrine infusion|DRUG: Lactated Ringer´s solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis in Non-pregnant Women
Status: UNKNOWN
Conditions: Syphilis Female
Interventions: DRUG: Cefixime|DRUG: Benzathine penicillin 2.4 million units
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Tolerability of Saracatinib in Subjects With Lymphangioleiomyomatosis (LAM) (SLAM-1)
Status: COMPLETED
Conditions: Pulmonary Lymphangioleiomyomatosis
Interventions: DRUG: Saracatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Nutrition Education Alone or With Acupuncture for Weight Loss in Breast Cancer Patients Post-Chemotherapy
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Nutrition Education|PROCEDURE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Estimate the Efficiency of the Association of an Injection of Ketamine and the Venlafaxine in the Severe Major Depressive Disorder for Six Weeks
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: ketamine venlafaxine|DRUG: Venlafaxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of High-dose Radiation Therapy Plus Chemotherapy to Improve the Likelihood of Surgical Treatment in Patients With Locally Advanced Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer
Interventions: RADIATION: Hypofractionated ablative IMRT (HFA-IMRT)|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of PB-119 Injection in Chinese Obese Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: DRUG: PB-119|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: (CB-01-02/06) Oral Budesonide-Multi-Matrix System (MMX) 9mg Extended Release Tablets
Status: COMPLETED
Conditions: Colitis, Ulcerative
Interventions: DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measuring Adherence in Subjects With Acne Vulgaris in a Clinic Population Subtitle: Topical Benzoyl Peroxide for Acne
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Benzoyl Peroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing Cancer Treatment Response to Therapy Using 18F-FSPG PET
Status: NOT_YET_RECRUITING
Conditions: Cancer|Diagnosis|Resistant Cancer|Response, Acute Phase
Interventions: DIAGNOSTIC_TEST: 18F-FSPG PET/CT in NSCLC|DIAGNOSTIC_TEST: 18F-FSPG PET/CT in HNSCC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PH 1 Study to Evaluate Safety and Tolerability of XmAb14045 in Patients With CD123-expressing Hematologic Malignancies
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|B-cell Acute Lymphoblastic Leukemia|Blastic Plasmacytoid Dendritic Cell Neoplasm|Chronic Myeloid Leukemia, Blast Crisis
Interventions: BIOLOGICAL: XmAb14045
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Metformin on Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fresh Corneal Lenticule Implantation and Autologous Serum - Case Report
Status: ACTIVE_NOT_RECRUITING
Conditions: Keratoconus|Keratoconus of Right Eye|Keratoconus, Unstable, Right Eye
Interventions: OTHER: Fresh corneal lenticule and autologous serum in advanced keratoconus using ReLex Smile surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Utilization and Safety of the Mk II Inserter and the Safety of the FAI Insert in Non-Infectious Uveitis
Status: COMPLETED
Conditions: Non-Infectious Uveitis
Interventions: DRUG: FAI Insert administered using the Mk II inserter|DRUG: FAI Insert administered using the Mk I inserter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Patients With Stage III-IVa Nasopharyngeal Carcinoma With or Without a Mobile Medical Platform Full-course Nutritional Intervention
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DEVICE: mobile platform or not mobile platform
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Improving Equitable Access to Naloxone to Prevent Opioid Overdose Deaths Within Syringe Service Programs (SAIA-Naloxone)
Status: RECRUITING
Conditions: Overdose|Implementation as Usual
Interventions: OTHER: Naloxone|OTHER: Usual intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of (Interleukin-12) IL-12 in Patients With Acute Myelogenous Leukemia (AML)
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: IL-12
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of the Vasodilator Test With Revatio, Made in Patients With Acute Pulmonary Hypertension
Status: UNKNOWN
Conditions: Pulmonary Hypertension
Interventions: DRUG: Sildenafil 20mg oral vs Sildenafil 10mg intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Fluorouracil and Irinotecan With or Without Leucovorin Compared With Observation in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: FOLFIRI regimen|DRUG: fluorouracil|DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Serum and Tissue Cefazolin Concentrations in Normal Weight Patients Undergoing Cesarean Delivery.
Status: WITHDRAWN
Conditions: Infection|Cesarean Delivery|Antibiotic Prophylaxis
Interventions: DRUG: Cefazolin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pooled Analysis of Methodologically Harmonized Pragmatic Randomized Trials of High-Dose vs. Standard-Dose Influenza Vaccine Against Severe Clinical Outcomes
Status: NOT_YET_RECRUITING
Conditions: Influenza
Interventions: BIOLOGICAL: High-Dose Influenza Vaccine|BIOLOGICAL: Standard-Dose Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab Deruxtecan (T-DXd): Tailoring Treatment and Companion Diagnostics (CDx) by Liquid Biopsy
Status: RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DIAGNOSTIC_TEST: HER2-D is the use of a non-invasive liquid biopsy method to non-invasively and objectively assess HER2 status at recruitment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Window of Opportunity Trial of Intratumoral Injection of Copaxone® in Patients With Percutaneously Accessible Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Cutaneous Squamous Cell Carcinoma|Squamous Cell Carcinoma|Basal Cell Carcinoma
Interventions: DRUG: Copaxone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Anesthesia on High- Grade Glioma Patients
Status: UNKNOWN
Conditions: Anesthesia, Outcome, High-grade Glioma
Interventions: OTHER: IV Anesthesia|OTHER: IH anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tailored Mobile Text Messaging to Reduce Problem Drinking
Status: COMPLETED
Conditions: Alcohol-Related Disorders|Alcohol Use Disorders|Alcohol Drinking|Alcoholism|Alcohol Abuse
Interventions: BEHAVIORAL: Adaptive Tailored Intervention|BEHAVIORAL: Consequence-based Intervention|BEHAVIORAL: Tailored, not adaptive, based Intervention|OTHER: Assessment only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lumbar Epidural Analgesia With Bilateral Erector Spinae Block for Pain Management in Lumbar Spine Surgery
Status: COMPLETED
Conditions: Perioperative Pain
Interventions: PROCEDURE: lumber epidural analgesia|PROCEDURE: erector spinae analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 35 kDa Hyaluronan Fragment (HA35) Reduces Chronic Inflammation of Skin
Status: RECRUITING
Conditions: Skin Inflammation|Cosmetic Skin
Interventions: DRUG: 35 kDa hyaluronan fragment HA35 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Reducing Dietary Intake of Red and Processed Meat Intake on Fasting Lipemia in Healthy Participants
Status: COMPLETED
Conditions: Lipidemia
Interventions: BEHAVIORAL: Meat reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cabozantinib and Abiraterone With Checkpoint Inhibitor Immunotherapy in Metastatic Hormone Sensitive Prostate Cancer (CABIOS Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Hormone Refractory Prostate Cancer
Interventions: DRUG: Cabozantinib|DRUG: Nivolumab|DRUG: Abiraterone acetate|DRUG: Prednisone|PROCEDURE: Peripheral blood collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Hemodynamic Effects, Safety and Tolerability of Chimeric Natriuretic Peptide (CD-NP) in Patients With Stabilized Acute Heart Failure (AHF)
Status: COMPLETED
Conditions: Acute Decompensated Heart Failure
Interventions: DRUG: CD-NP (Chimeric natriuretic peptide)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Plus Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: etoposide|DRUG: paclitaxel|DRUG: topotecan hydrochloride|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antimicrobial Solution or Saline Solution in Maintaining Catheter Patency and Preventing Catheter-Related Blood Infections in Patients With Malignancies
Status: WITHDRAWN
Conditions: Chronic Myeloproliferative Disorders|Infection|Leukemia|Lymphoma|Lymphoproliferative Disorder|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: Edetate Calcium Disodium|DRUG: Ethanol|DRUG: Trimethoprim-sulfamethoxazole|OTHER: Hypertonic Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of the Effects of Oral Prednisone in Patients With Rheumatoid Arthritis (MK0000-088)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Prednisone 15 mg|DRUG: Placebo Tablets|DRUG: Prednisone 7.5 mg|DRUG: Placebo Over-Encapsulated Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Follow-up of Patients Treated With Genetically Modified Autologous T Cells
Status: ENROLLING_BY_INVITATION
Conditions: Patients Followed for up to 15 Years Following Their First Dose of AUTO CAR T Cell Therapy|Multiple Myeloma|DLBCL|ALL, Adult and Pediatric|T Cell Lymphoma
Interventions: BIOLOGICAL: AUTO CAR T cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety Study of Enzalutamide in Combination With Exemestane in Patients With Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Enzalutamide|DRUG: exemestane|DRUG: Placebo (for enzalutamide)|DRUG: exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prephase Treatment With Prednisone +/- Vitamin D Supplementation Followed by Immunochemotherapy
Status: RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma|Elderly Patients
Interventions: DRUG: Vitamin D3 (Cholecalciferol)|DRUG: RCHOP o R-miniCHOP at standard doses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Malignant and Premalignant Lesions in the Head & Neck in Patients With Chronic Obstructive Pulmonary Disease
Status: UNKNOWN
Conditions: COPD, HEAD&NECK CANCER,SCREENING
Interventions: OTHER: Stroboscopic nasopharyngeal laryngoscopy|OTHER: Stroboscopic nasopharyngeal laryngoscopy|OTHER: Stroboscopic nasopharyngeal laryngoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preoperative Nab-paclitaxel, Cisplatin, and Gemcitabine Chemotherapy With or Without Infigratinib Targeted Therapy for the Treatment of Resectable Intrahepatic Cholangiocarcinoma, The OPTIC Trial
Status: WITHDRAWN
Conditions: Resectable Intrahepatic Cholangiocarcinoma|Stage 0 Intrahepatic Cholangiocarcinoma AJCC v8|Stage I Intrahepatic Cholangiocarcinoma AJCC v8|Stage II Intrahepatic Cholangiocarcinoma AJCC v8|Stage III Intrahepatic Cholangiocarcinoma AJCC v8
Interventions: DRUG: Cisplatin|DRUG: Gemcitabine Hydrochloride|DRUG: Infigratinib Phosphate|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: : Pharmacokinetics of Enoxaparin After Coronary Artery Bypass Graft Surgery
Status: COMPLETED
Conditions: Venous Thromboembolism|Pulmonary Embolism|Thromboprophylaxis
Interventions: DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Perioperative Lignocaine and Sleep Disturbance
Status: UNKNOWN
Conditions: Sleep Disturbance
Interventions: DRUG: Lidocaïne 2%|DRUG: Placebo (for Lidocaïne)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cediranib as Palliative Treatment in Patients With Symptomatic Malignant Ascites or Pleural Effusion
Status: TERMINATED
Conditions: Malignant Ascites|Malignant Pleural Effusion
Interventions: DRUG: immediate cediranib|DRUG: Start cediranib after 28 days Best Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancement of Behavioral and Cognitive Outcomes in Autism Spectrum Disorder Via Neurostimulation
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DEVICE: Trans Cranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An International Double Cohort Study to Compare Laparoscopic Ventral Rectopexy With Laparoscopic Resection Rectopexy
Status: TERMINATED
Conditions: Rectal Prolapse|Procidentia
Interventions: PROCEDURE: Laparoscopic Resection Rectopexy|PROCEDURE: Laparoscopic Ventral Rectopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PS-341 in Combination With Herceptin in Advanced Breast Cancer That Overexpresses HER-2
Status: COMPLETED
Conditions: Carcinoma Breast Stage IV
Interventions: DRUG: Combination of trastuzumab and PS-341
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Untreated B-Cell Non-Hodgkin Lymphoproliferative Diseases
Status: ACTIVE_NOT_RECRUITING
Conditions: Follicular Lymphoma|Indolent B-Cell Non-Hodgkin Lymphoma|Marginal Zone Lymphoma
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Safety and Tolerability of Vabicaserin in Patients With Sudden Worsening of Schizophrenia
Status: WITHDRAWN
Conditions: Schizophrenia
Interventions: DRUG: SCA-136 50mg/day|DRUG: SCA-136 150 mg/day|DRUG: SCA-136 300mg/day|DRUG: Risperidone 4mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Blood Glucose and Body Fat Regulatory Effect of Peanut Skin Extract
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Sugarlock®|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Safety and Efficacy of PT010, PT003, and PT009 in Japanese Subjects With COPD Compared With Symbicort® Turbohaler®
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: BGF MDI (PT010)|DRUG: GFF MDI (PT003)|DRUG: BFF MDI (PT009)|DRUG: Symbicort® Turbohaler® Inhalation Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sevoflurane vs. Isoflurane for Low-Flow General Anaesthesia for Abdominal Surgery
Status: COMPLETED
Conditions: Anaesthesia
Interventions: DRUG: sevoflurane|DRUG: isoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Minimal Clinical Important Change of the Turkish Versions of the FABQ TKS, and PCS in Patients With Chronic Neck Pain
Status: NOT_YET_RECRUITING
Conditions: Neck Pain|Kinesiophobia|Fear of Movement
Interventions: OTHER: Pain Catastrophizing scale
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Preemptive Analgesic Effects of Dexketoprofen Versus Dexmedetomidine on Abdominal Hysterectomy Patients
Status: UNKNOWN
Conditions: Pain
Interventions: DRUG: dexketoprofen trometamol|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Milk Fat Globule Membrane (MFGM) on Gut Barrier Protection in Runners
Status: COMPLETED
Conditions: Inflammation
Interventions: DIETARY_SUPPLEMENT: Milk fat globule membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Impact of Quetiapine on the Drug Abuse Patterns of Addicted Schizophrenic Patients
Status: COMPLETED
Conditions: Schizophrenia|Substance Use Disorders
Interventions: DRUG: quetiapine (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Exercise, Brain, Cognition, OMICs, Molecular Markers and Functionality in People at Risk of Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Alzheimer Dementia
Interventions: BEHAVIORAL: Supervised Exercise Programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Seroprevalence Study of CoV-2-SARS (COVID-19) Infection in Patients With Chronic Inflammatory Rheumatic Diseases
Status: COMPLETED
Conditions: COVID-19|SARS-CoV Infection|Rheumatoid Arthritis|Spondyloarthritis|Ankylosing Spondylitis|Psoriatic Arthritis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multi-Level Stigma Intervention for Mental Health Services
Status: ACTIVE_NOT_RECRUITING
Conditions: Social Stigma|Substance Use Disorders|Mental Disorder
Interventions: BEHAVIORAL: Multi-level stigma reduction intervention: educational training plus controlled substance agreement policy change|BEHAVIORAL: Single-level stigma reduction intervention: educational training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study Evaluating Pharmacokinetics and Mass Balance of [14C]-CTP-543 in Healthy Adult Male Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: [14C]-CTP-543
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized and Multicenter Study to Evaluate a Customizable Support Breast Cancer Material
Status: COMPLETED
Conditions: Breast Cancer|Knowledge, Attitudes, Practice|Patient Empowerment|Patient Satisfaction
Interventions: OTHER: Customizable support material|OTHER: Non-customizable support material
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Vitamin D Supplementation and Improvement of PCOS Therapy and IVF Outcomes in Infertile Saudi Women
Status: UNKNOWN
Conditions: Female Infertility|Polycystic Ovary Syndrome|Pathologic Processes|Vitamin D Deficiency|IVF|Vitamin D Supplement
Interventions: DRUG: Vitamin D3|DRUG: Clomiphene Citrate|DRUG: Letrozole|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EUS-RFA Versus Surgery for Pancreatic Insulinoma (ERASIN-RCT)
Status: RECRUITING
Conditions: Pancreatic Insulinoma
Interventions: PROCEDURE: Endoscopic ultrasound-guided radio frequency ablation|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Goal Directed Therapy Using a Physiological Holistic View. The ANDROMEDA-SHOCK Study
Status: COMPLETED
Conditions: Septic Shock|Hyperlactatemia|Peripheral Perfusion
Interventions: OTHER: Peripheral Perfusion guided resuscitation|OTHER: Lactate guided resuscitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alternate Dosing Study of MK-6024 in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (MK-6024-016)
Status: RECRUITING
Conditions: Metabolic Dysfunction-Associated Steatotic Liver Disease|Non-alcoholic Fatty Liver Disease|Nonalcoholic Fatty Liver Disease|Liver Disease
Interventions: DRUG: Efinopegdutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transdiagnostic Group Behavioral Activation for Autistic Adults
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Depression, Anxiety|Anxiety|Anger
Interventions: BEHAVIORAL: Group Behavioral Activation Therapy for Autism Spectrum Disorder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study of AGA111 in Patients With Degenerative Disc Disease Undergoing Lumbar Interbody Fusion
Status: RECRUITING
Conditions: Degenerative Disc Disease
Interventions: DRUG: AGA111|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Immunoradiotherapy in Head & Neck Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Nivolumab|PROCEDURE: Surgical Resection|RADIATION: Radiation (5 days)|RADIATION: Radiation (3 days)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET Patterns, Biomarkers and Outcome in Burst SCS Treated FBSS Patients
Status: UNKNOWN
Conditions: FBSS|Pain, Intractable|Low Back Pain|Radicular; Neuropathic, Lumbar, Lumbosacral
Interventions: DEVICE: Proclaim™ Elite 5: Burst - Washout - Sham|DEVICE: Proclaim™ Elite 5: Sham - Washout - Burst
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intra-cortical Inhibition and Cognitive Deficits in Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia
Interventions: DEVICE: Transcranial Magenetic Stimulation|DEVICE: Sham Transcranial Magenetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Healthcare Economic OutcoMes From ReAl-worlD Use in Europe of an AI Software During AF Ablation
Status: RECRUITING
Conditions: Atrial Fibrillation|Atrial Arrhythmia|Arrhythmias, Cardiac
Interventions: DEVICE: Cardiac mapping
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Localized Resectable Neuroblastoma|Localized Unresectable Neuroblastoma|Recurrent Neuroblastoma|Regional Neuroblastoma|Stage 4 Neuroblastoma|Stage 4S Neuroblastoma
Interventions: BIOLOGICAL: Aldesleukin|BIOLOGICAL: Dinutuximab|DRUG: Isotretinoin|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|OTHER: Quality-of-Life Assessment|BIOLOGICAL: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of the Duration of the Dual Antiplatelet Therapy by the Degree of the Coverage of The Struts on Optical Coherence Tomography From the Randomized Comparison Between Everolimus-eluting Stents Versus Biolimus A9-eluting Stents
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy Study of a Device Allowing Broadcasting Maternal Voice and Heartbeat in Preterm Newborn (CALIPREM)
Status: UNKNOWN
Conditions: Preterm Newborn
Interventions: DEVICE: calinange
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Efficacy of Angulated Screw-retained and Cemented Single Implant Crowns in Esthetic Region
Status: COMPLETED
Conditions: Angulated Screw-retained|Esthetics
Interventions: DEVICE: angulated screw retained crown|DEVICE: cemented crown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Analgesic Efficacy of PENB Block With FICB in Post Operative Hip Fracture Patients
Status: COMPLETED
Conditions: Post-operative Pain Management|Hip Fracture Surgery
Interventions: DRUG: PENG block|DRUG: FICB Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Scar Appearance After Postoperative Hydrocolloid Dressing Versus Standard Petrolatum Ointment
Status: COMPLETED
Conditions: Scar|Skin Scarring|Skin Cancer|Wound Heal|Wound of Skin|Surgical Wound|Patient Satisfaction|Patient Preference|Surgical Incision
Interventions: DEVICE: Hydrocolloid dressing|OTHER: Petrolatum jelly dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Initial Volume Status in Patients With Acute Brain Injury is Associated With Neurological Prognosis
Status: COMPLETED
Conditions: Acute Brain Injury|Paroxysmal Sympathetic Hyperactivity|Volume Status|Right Heart Function|Right Cardiogenic Pulmonary Edema|Glasgow Outcome Scale Extended
Interventions: OTHER: Ultrasound evaluation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase I Study of SHR -2001 in Healthy Subjects
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: SHR-2001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Photobiomodulation Therapy Combined With Static Magnetic Field in Patients With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: Active PBMT|DEVICE: Placebo PBMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short Course Intermittent Regimens for the Treatment of HIV-Associated Tuberculosis
Status: UNKNOWN
Conditions: Tuberculosis|Human Immunodeficiency Virus Infections
Interventions: DRUG: Anti-TB drugs (Ethambutol, Isoniazid, Rifampicin and Pyrazinamide)|DRUG: Anti-TB drugs (Ethambutol, Isoniazid, Rifampicin and Pyrazinamide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of CJ-12420 in Patients With Gastric Ulcer
Status: COMPLETED
Conditions: Gastric Ulcer
Interventions: DRUG: CJ-12420 50 mg QD|DRUG: CJ-12420 100 mg QD|DRUG: Lansoprazole 30 mg QD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endolaserless Vitrectomy With Intravitreal IAI for PDR-Related VH
Status: UNKNOWN
Conditions: Proliferative Diabetic Retinopathy
Interventions: DRUG: Aflibercept|PROCEDURE: Endolaserless Vitrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Oxybutynin for Treating Hyperhidrosis: A Placebo-control Study
Status: COMPLETED
Conditions: Hyperhidrosis
Interventions: DRUG: Oxybutynin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Alberta FYBER (Feed Your Gut Bacteria morE fibeR) Study
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: OTHER: Microcrystalline Cellulose Supplementation|OTHER: Acacia Gum Supplementation|OTHER: Resistant Starch Type 4 Supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Pilot Study of Aerosol Interferon-gamma for Treatment of Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Pulmonary Fibrosis
Interventions: DRUG: aerosol interferon-gamma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy, Safety, and Tolerability Study for TA-7284 in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: TA-7284-Low|DRUG: TA-7284-Low-middle|DRUG: TA-7284-High-middle|DRUG: TA-7284-High|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ETA and AT1 Antagonism in ANCA-vasculitis (SPARVASC)
Status: ACTIVE_NOT_RECRUITING
Conditions: ANCA Associated Vasculitis|Cardiovascular Diseases|Kidney Diseases
Interventions: DRUG: Sparsentan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Placebo Controlled Trial Evaluating the Impact of Nystatin on the Development of Oral Irritation in Patients Receiving High Dose Intravenous Interleukin-2
Status: COMPLETED
Conditions: Candidiasis, Oral|Gastrointestinal Diseases|Stomatitis
Interventions: DRUG: Nystatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT