pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to Corticosteroids Intrabursal Injection
Status: COMPLETED
Conditions: Tendinopathy|Adrenal Insufficiency
Interventions: DRUG: methylprednisolone acetate|DRUG: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: FibroTouch Non-invasive Evaluation of Liver Fibrosis and Cirrhosis
Status: UNKNOWN
Conditions: Liver Fibrosis|Cirrhosis|Chronic Hepatitis B
Interventions: DEVICE: FibroTouch Examination|DEVICE: FibroScan Examination|DEVICE: Ultrasonic B Examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of AcrySof IQ Vivity Extended Vision Intraocular Lenses
Status: NOT_YET_RECRUITING
Conditions: Aphakia|Presbyopia|Residual Refractive Cylinder
Interventions: DEVICE: AcrySof IQ Vivity Extended Vision IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Energy Value of Macronutrients From Pistachio Nuts and Mechanisms of Nutrient Action
Status: COMPLETED
Conditions: Energy|Cardiovascular Disease|Cancer
Interventions: OTHER: 1.5PD|OTHER: 3.0PD|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Phase I Study of Irinotecan (CPT-11) Administered as a Prolonged Infusion in Adult Patients With Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: irinotecan (CPT-11)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Provider Awareness and Cultural Dexterity Toolkit for Surgeons Trial
Status: COMPLETED
Conditions: Resident Knowledge and Attitudes Regarding Cross-cultural Care|Interpersonal and Communication Skills in Patient-clinician Encounters|Patient-reported Satisfaction With Resident Physicians Involved in Their Care|Patients' Clinical Health Outcomes After Surgery
Interventions: OTHER: PACTS curriculum|OTHER: Standard Residency Curriculum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Neoadjuvant Therapy for Ovarian Cancer
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer|Primary Peritoneal Cancer|Fallopian Tube Cancer
Interventions: DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testosterone for Treating Cachexia in Patients With Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Cachexia|Squamous Cell Carcinoma
Interventions: DRUG: Placebo Testosterone|DRUG: Testosterone Enanthate 100 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial Evaluating the Interest of Noninvasive Ventilation in NAVA Mode in Respiratory Decompensations Children With Infantile Spinal Muscular Atrophy Type II
Status: COMPLETED
Conditions: Infantile Spinal Muscular Atrophy
Interventions: DEVICE: NAVA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The PhINEST Study - Pharyngeal ICU Novel Electrical Stimulation Therapy
Status: RECRUITING
Conditions: Dysphagia
Interventions: DEVICE: Pharyngeal Electrical Stimulation (PES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 11C-methionine in Diagnostics and Management of Glioblastoma Multiforme Patients (GlioMET)
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma Multiforme
Interventions: DRUG: 11C-Methionine PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of AVE1642 Anti-IGF1R Monoclonal Antibody in Patients With Advanced Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: AVE1642|DRUG: Velcade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Severe Heart Failure and Homebased Rehabilitation - An Intersectoral Randomized Controlled Trial
Status: UNKNOWN
Conditions: Chronic Heart Failure|Heart Failure NYHA Class II|Heart Failure NYHA Class III|Heart Failure NYHA Class IV
Interventions: OTHER: Early homebased rehabilitation after hospital admission|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Open-label Interventional Study of Intravenous Recombinant Coagulation Factor VIII Fc-von Willebrand Factor-XTEN Fusion Protein, Efanesoctocog Alfa (BIVV001), in Patients With Severe Hemophilia A
Status: COMPLETED
Conditions: Factor VIII Deficiency
Interventions: BIOLOGICAL: efanesoctocog alfa (BIVV001)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Paxman Scalp Cooling to Prevent Chemo Induced Alopecia in Black Patients With Breast or GYN Cancers
Status: COMPLETED
Conditions: Breast Cancer|Ovarian Cancer|Gynecologic Neoplasm|Endometrial Cancer
Interventions: DEVICE: Paxman Scalp Cooling Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of the Fully Immersive Leisure-based Virtual Reality Cognitive Training for Community-dwelling Elderly
Status: UNKNOWN
Conditions: Community-dwelling Elderly|Virtual Reality
Interventions: BEHAVIORAL: VR cognitive training|BEHAVIORAL: Traditional cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sternal Block With Liposomal Bupivacaine vs. Saline Prior to Incision in Cardiac Surgery
Status: RECRUITING
Conditions: Cardiovascular Surgery|Pain, Postoperative|Block
Interventions: DRUG: Liposomal bupivacaine|DRUG: Normal Saline Flush, 0.9% Injectable Solution_#1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Specialised Physical Education in Volleyball on Middle School Students' Physical Fitness and Performance
Status: RECRUITING
Conditions: Physical Fitness|Performance
Interventions: BEHAVIORAL: Volleyball|BEHAVIORAL: Traditional Physical Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacokinetics, Biodistribution, Radiation Dose and Safety Study of 68Ga-NYM032 in Patients
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: 68Ga-NYM032 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Pharmacokinetics Study of Human Monoclonal Antibody (AVP-21D9)
Status: COMPLETED
Conditions: Anthrax
Interventions: DRUG: AVP-21D9|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Pharmacokinetic Profiles and Safety of CKD-386 in Healthy Volunteers Under Fasting Conditions
Status: COMPLETED
Conditions: Hypertension and Dyslipidemia
Interventions: DRUG: CKD-386(4) F1|DRUG: CKD-386(4) F2|DRUG: D013, D326, D337
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NBMI Treatment in Patients With Mercury Toxicity
Status: RECRUITING
Conditions: Mercury Poisoning
Interventions: DRUG: (N1, N3-bis(2- mercaptoethyl)isophthalamide)|OTHER: Excipients microcrystalline cellulose, silica and magnesium stearate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Physiological Evaluation of an Investigational Mask With Expiratory Washout.
Status: NOT_YET_RECRUITING
Conditions: Acute Hypercapnic Respiratory Failure|Acute Hypoxemic Respiratory Failure
Interventions: DEVICE: Investigational full-face mask with expiratory washout|DEVICE: Conventional full-face mask - single-limb|DEVICE: Conventional full-face mask - dual-limb
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Natural Senolytic Agents & NLRP3 Inhibitors on Osteoarthritis
Status: SUSPENDED
Conditions: Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: Quercetin and Fisetin tab.|DIETARY_SUPPLEMENT: Quercetin Cap/Tab,Fisetin Cap/tab and Glycyrrhizin capsules|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evidence of Spreading Vasodilation in Human Gingiva
Status: COMPLETED
Conditions: Nitric Oxide|Vasodilation|Oral Soft Tissue Conditions
Interventions: DRUG: nitroglycerin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Ambervin® and Standard Therapy in Hospitalized Patients With COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Tyrosyl-D-alanyl-glycyl-phenylalanyl-leucyl-arginine succinate intramuscularly|DRUG: Tyrosyl-D-alanyl-glycyl-phenylalanyl-leucyl-arginine succinate inhaled|DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Migalastat Food Effect Study
Status: COMPLETED
Conditions: Fabry Disease
Interventions: DRUG: A (migalastat)|DRUG: B (migalastat)|DRUG: C (migalastat)|DRUG: D (migalastat)|DRUG: E (migalastat)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retrospective Analysis of Treatment Outcomes in Patients With Bacterial Overgrowth Syndrome Diagnosed by D-Xylose Breath Testing
Status: COMPLETED
Conditions: Small Intestinal Bacterial Overgrowth Syndrome (SIBO)|Small Bowel Bacterial Overgrowth Syndrome (SBBOS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Biomarkers in Patients With Advanced Rhabdomyosarcoma
Status: COMPLETED
Conditions: Adult Rhabdomyosarcoma|Childhood Alveolar Rhabdomyosarcoma|Childhood Embryonal Rhabdomyosarcoma|Previously Treated Childhood Rhabdomyosarcoma|Recurrent Adult Soft Tissue Sarcoma|Recurrent Childhood Rhabdomyosarcoma|Stage III Adult Soft Tissue Sarcoma|Stage IV Adult Soft Tissue Sarcoma
Interventions: OTHER: Laboratory Biomarker Analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Open Label SLV308 Safety Extension to Study S308.3.002 in Patients With Parkinson's Disease Experiencing Motor Fluctuations.
Status: COMPLETED
Conditions: Advanced Stage Parkinson's Disease
Interventions: DRUG: Pardoprunox
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Follow-Up Study Evaluating The Long Term Safety and Efficacy of BST-CarGel and Microfracture Repair of the Knee
Status: COMPLETED
Conditions: Knee Injuries
Interventions: DEVICE: Microfracture with BST-CarGel|DEVICE: Microfracture without BST-CarGel
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluate Initial Safety of the HemiBridge™ System in Guided Spinal Growth Treatment of Progressive Idiopathic Scoliosis
Status: COMPLETED
Conditions: Scoliosis
Interventions: DEVICE: Mechanical hemiepiphysiodesis using the HemiBridge System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Knee Injuries in Adolescent Female Football Players
Status: COMPLETED
Conditions: Knee Injury
Interventions: BEHAVIORAL: Knäkontroll, SISU Idrottsböcker©, Sweden, 2005
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Music Beat on Motor Function in Individuals at Risk for Psychotic Onset and Schizophrenia Patients
Status: RECRUITING
Conditions: Schizophrenia|Psychosis|Parkinsonism|Dyskinesias
Interventions: BEHAVIORAL: Rhythmic auditory stimulation (RAS)|BEHAVIORAL: no RAS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dental Age Estimation by Different Methods in Patients With Cleft Lip and Palate
Status: RECRUITING
Conditions: Dental Age Estimation|Cleft Lip and Palate
Interventions: OTHER: Diagnostic Test: Willems method|OTHER: Diagnostic Test: Cameriere method|OTHER: Diagnostic Test: London Atlas method
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acute Dose-dependent Effects of DMT-bolus Applications in Healthy Subjects (DMT BDR-Study)
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DRUG: N,N-Dimethyltryptamine (5mg)|DRUG: N,N-Dimethyltryptamine (10mg)|DRUG: N,N-Dimethyltryptamine (15mg)|DRUG: N,N-Dimethyltryptamine (20mg)|DRUG: N,N-Dimethyltryptamine (25mg)|DRUG: Placebo (saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Four-Week Study Comparing Acetaminophen Extended Release and Rofecoxib in the Treatment of Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: acetaminophen|DRUG: Rofecoxib|DRUG: Rofecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adipose Tissue Imaging in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: RADIATION: 18F-FDG PET/CT|DEVICE: euglycemic clamp|DEVICE: hypoglycemic clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of PreforPro® on Urinary and Vaginal Health
Status: NOT_YET_RECRUITING
Conditions: Bacterial Vaginosis|Bacterial Infections|Bacterial Vaginosis &#X7C; Vaginal &#X7C; Microbiology|Vaginal Infection
Interventions: DRUG: Preforpro|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Gut Microbiota in Regulating Nutrient Absorption in Humans
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Vancomycin|DRUG: Placebo oral tablet|OTHER: Overfeeding diet (OF)|OTHER: Underfeeding diet (UF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MAKO-Uni-Knee Arthroplasty Clinical Outcomes and Function
Status: COMPLETED
Conditions: Clinical Outcomes
Interventions: PROCEDURE: Unicompartmental knee arthroplasty with the Mako Robotic Arm-assisted system.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Carfilzomib Weekly Plus Melphalan and Prednisone in Untreated Symptomatic Elderly Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Carfilzomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bicarbonate v Saline to Prevent Contrast Nephropathy
Status: TERMINATED
Conditions: Kidney Failure, Acute|Contrast Media
Interventions: DRUG: 0.9% (154 mEq/L) IV Sodium Chloride|DRUG: 1/6 M (166 mEq/L) IV Sodium Bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial of Subretinal Injection of (rAAV2-VMD2-hMERTK)
Status: COMPLETED
Conditions: Retinal Disease|Retinitis Pigmentosa
Interventions: BIOLOGICAL: Subretinal administration of rAAV2-VMD2-hMERTKRecombinant Adeno-Associated Virus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin K and Bone Turnover in Postmenopausal Women
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: phylloquinone (K1)|DRUG: menatetranone (MK4)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Nasoalveolar Molding for Egyptian Cleft Lip Palate Infants
Status: COMPLETED
Conditions: Cleft Lip Palate|Cleft Lip, Unilateral, Complete
Interventions: DEVICE: Nasoalveolar molding therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Of A Recombinant H5N1 Vaccine In Adults
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: HAI-05 Influenza Vaccine|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: S0400, FR901228 in Treating Patients With Advanced Cancer of the Urothelium
Status: TERMINATED
Conditions: Bladder Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter|Urethral Cancer
Interventions: DRUG: Depsipeptide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-48816274
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-48816274|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous Treatment With Icatibant for Acute Attacks of Hereditary Angioedema
Status: COMPLETED
Conditions: Angioedema
Interventions: DRUG: Icatibant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous Median Nerve Neuromodulation For Drug-Treatment Resistant Hypertension.
Status: WITHDRAWN
Conditions: Resistant Hypertension
Interventions: DEVICE: eCoin System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating the Efficacy and Tolerability of SSR125543 in Outpatients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depression
Interventions: DRUG: SSR125543|DRUG: escitalopram|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cost-utility and Physiological Effects of LDN in Patients With Fibromyalgia
Status: ACTIVE_NOT_RECRUITING
Conditions: Randomized Controlled Trial
Interventions: DRUG: Low-dose naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect on Lung Function of an Approved COPD Treatment (BGF, With HFA Propellant) Compared to BGF Formulated With a New Propellant (HFO) in Participants 40 to 80 Years of Age With COPD
Status: RECRUITING
Conditions: COPD (Chronic Obstructive Pulmonary Disease)
Interventions: DRUG: BGF MDI HFO 320/14.4/9.6μg|DRUG: BGF MDI HFA 320/14.4/9.6 μg|DRUG: Placebo MDI HFA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-operative Electrical Muscle Stimulation to Stimulate Muscle Protein Synthesis in Humans
Status: ACTIVE_NOT_RECRUITING
Conditions: Skeletal Muscle Atrophy
Interventions: OTHER: Neuromuscular electrical stimulation (NMES/0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Phase II Study of Epirubicin vs Caelyx in Pretreated Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Pegylated liposomal doxorubicin (Caelyx)|DRUG: Epirubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Potassium From Potatoes and Potassium Gluconate
Status: COMPLETED
Conditions: Potassium Bioavailability|Blood Pressure
Interventions: DIETARY_SUPPLEMENT: Placebo control|DIETARY_SUPPLEMENT: Low dose potassium gluconate|DIETARY_SUPPLEMENT: Medium dose potassium gluconate|DIETARY_SUPPLEMENT: High dose potassium gluconate|DIETARY_SUPPLEMENT: Low dose potato|DIETARY_SUPPLEMENT: Medium dose potato|DIETARY_SUPPLEMENT: High dose potato|DIETARY_SUPPLEMENT: High dose French fries|DIETARY_SUPPLEMENT: Basal diet control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Randomized, Double-Blind, Comparator- and Placebo-Controlled, Multiple-Dose Study to Evaluate the Safety, Tolerability and Efficacy of Three Dose Levels of MSDC-0602 in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo|DRUG: MSDC-0602 100 mg|DRUG: MSDC-0602 250 mg|DRUG: MSDC-0602 250 mg|DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of a Physical Therapy-yoga-patient Educational Program for Breast Cancer Patients With Pain Due to Hormonal Therapy Treatment.
Status: RECRUITING
Conditions: Breast Cancer
Interventions: BEHAVIORAL: educational yoga program|OTHER: no intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study of Customized Adjustable Oral in Treatment of Patients With Obstructive Sleep Apnea Syndrome
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea Syndrome
Interventions: DEVICE: Adjustable Oral Appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Stimulation in the Elderly: Individual Intervention on Cognitive Frailty
Status: UNKNOWN
Conditions: Neurocognitive Disorders|Dementia
Interventions: OTHER: Individual Cognitive Stimulation Therapy Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy Study of Co-transfering of Mesenchymal Stem Cell and Regulatory T Cells in Treating End-stage Liver Disease
Status: NOT_YET_RECRUITING
Conditions: Liver Cirrhosis
Interventions: BIOLOGICAL: MSC and Tregs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone Dose in Low Volume Bupivacaine USG Supraclavicular Block
Status: UNKNOWN
Conditions: Dexamethasone|Supraclavicular Brachial Plexus Block
Interventions: PROCEDURE: Ultrasound guided supraclavicular brachial plexus block|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Two Formulations of Erythropoietin
Status: COMPLETED
Conditions: Comparison of the Efficacy of Two Formulations of Epoetin in Patients Undergoing Hemodialysis
Interventions: DRUG: Epoetin Alfa-BioManguinhos|DRUG: Epoetin Alfa-BioSimilar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Chronic Treatment by β1-adrenergic Antagonists on Nociceptive-Level (NOL) Index Variation After a Standardized Noxious Stimulus Under General Anesthesia
Status: COMPLETED
Conditions: Nociception During Anesthesia in Patients Taking β1-adrenergic Antagonist Chronic Treatment
Interventions: PROCEDURE: standardized noxious stimulus under general anesthesia.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Auriculotherapy on Older People With Insomnia
Status: COMPLETED
Conditions: Insomnia
Interventions: DEVICE: magneto-auriculotherapy (MAT)|DEVICE: Laser auriculotherapy (LAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bronchiectasis in Chronic Obstructive Pulmonary Disease (COPD) Patients: Role of Prophylaxis
Status: TERMINATED
Conditions: Bronchiectasis|Pulmonary Disease|Chronic Bronchitis
Interventions: DRUG: azithromycin and fluticasone|DRUG: fluticasone and azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Lenalidomide With Rituximab in Refractory or Relapse of Primary Central Nervous System Lymphoma
Status: COMPLETED
Conditions: Lymphoma|Relapse
Interventions: DRUG: Lenalidomide|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of PLT Health Solutions zümXR Extended-Release Caffeine
Status: RECRUITING
Conditions: Caffeine|Cognitive Change|Mood|Mood Change
Interventions: DIETARY_SUPPLEMENT: xumXR extended release caffeine|DIETARY_SUPPLEMENT: immediate release caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Establish the PK of Belinostat in Patients With Wild-type, Heterozygous, and Homozygous UGT1A1*28 Genotypes
Status: COMPLETED
Conditions: Solid Tumors|Hematological Malignancies
Interventions: DRUG: Belinostat IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project Power: An HIV Risk Reduction Intervention for Black Men Who Have Sex With Men and Women (BMSM/W)
Status: COMPLETED
Conditions: Unsafe Sex|Risk Reduction
Interventions: BEHAVIORAL: PROJECT POWER|BEHAVIORAL: Power Health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Metastasis Directed Stereotactic Body Radiotherapy for Oligo Metastatic Hormone Sensitive Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer Metastatic|Radiation Therapy|Positron-Emission Tomography
Interventions: RADIATION: stereotactic body radiotherapy|DRUG: androgen deprivation therapy|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Assessing Esophageal Function and Remodeling With Dupilumab Compared With Placebo for 24 Weeks Followed by 104 Weeks Open Label in Adult Participants With EoE (REMOdeling With Dupilumab in Eosinophilic Esophagitis Long-term Trial)
Status: RECRUITING
Conditions: Eosinophilic Oesophagitis
Interventions: DRUG: Dupilumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Therapy for Localized Rectal Adenocarcinoma
Status: WITHDRAWN
Conditions: Rectal Adenocarcinoma
Interventions: OTHER: Chemoradiation|RADIATION: short course radiation therapy|DRUG: mFOLFOX6|DRUG: CAPOX|DRUG: fluoropyrimidine +/- oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Hydrogen-Rich Celsior Solution Applied in Aging DBD Liver/Kidney Transplantation
Status: UNKNOWN
Conditions: Evidence of Liver Transplantation
Interventions: DRUG: Hydrogen-Rich Celsior Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Promoting Female Empowerment at the Household Level Among Couples in Ibadan, Nigeria
Status: COMPLETED
Conditions: Gender Role|Woman's Role|Couples|Literacy|Family Size
Interventions: BEHAVIORAL: Gender Socialization Training workshop|BEHAVIORAL: Financial Literacy Training Intervention|BEHAVIORAL: Family Planning Counseling and Services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of Combined Pharmacotherapy Versus Solifenacin With Vaginal Estrogen Cream for Women With Detrusor Overactivity
Status: RECRUITING
Conditions: Urinary Bladder, Overactive|Effect of Drug
Interventions: DRUG: Solifenacin with vaginal estrogen cream|DRUG: Combination pharmacotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Computer Aided Diagnosis (CADx) for Colorectal Polyps Resect-and-Discard Strategy
Status: RECRUITING
Conditions: Colonic Polyp
Interventions: PROCEDURE: AI-powered computer-aided diagnosis (CADx)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Unique Regimen for Treatment of Helicobacter Pylori Infection
Status: UNKNOWN
Conditions: Helicobacter Infections
Interventions: DRUG: Quadruple therapy|DRUG: Classic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Kinesotaping on Management of Supraspinatus Tendinitis
Status: COMPLETED
Conditions: Supraspinatus Tendinitis
Interventions: OTHER: Group I Experimental Kinesotaping|OTHER: Group II conventional training group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prehospital Laryngeal Tube vs. Bag-Valve Mask Ventilation Used by Paramedics During CPR
Status: TERMINATED
Conditions: Cardiac Arrest During and/or Resulting From A Procedure
Interventions: DEVICE: Bag-valve mask or laryngeal tube ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Nesiritide on Early Postoperative Recovery After Total Cavo-Pulmonary Connection Surgery in Children
Status: UNKNOWN
Conditions: Congenital Heart Disease|Total Cavo-pulmonary Connection
Interventions: DRUG: Nesiritide|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Nurse-led Integrative Health and Wellness Programme Among Newly Diagnosed Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Nurse-led Integrative health and wellness programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Everolimus in Combination With Trastuzumab and Paclitaxel in the Treatment of HER2 Positive Locally Advanced or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Everolimus|DRUG: Placebo|DRUG: Trastuzumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Relugolix in Men With Advanced Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Relugolix|DRUG: Leuprolide Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effect of Low Torque and Speed on Post-Operative Pain After Root Canal Treatment
Status: NOT_YET_RECRUITING
Conditions: Dental Pulp Necrosis
Interventions: DEVICE: use of VDW Silver Endodontic motor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Deep Brain Stimulation of Nucleus Accumbens to Treat Severe Anorexia Nervosa
Status: UNKNOWN
Conditions: Anorexia Nervosa
Interventions: PROCEDURE: Deep brain stimulation|OTHER: Fluoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RIvaroxaban for Valvular Heart diseasE and atRial Fibrillation Trial -RIVER Trial
Status: COMPLETED
Conditions: Valvular Heart Disease
Interventions: DRUG: Rivaroxaban|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Adherence to Smoking Cessation Medication Among PLWHA
Status: COMPLETED
Conditions: Tobacco Use Cessation
Interventions: DRUG: Varenicline|BEHAVIORAL: Text Message|BEHAVIORAL: Adherence Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methylphenidate Treatment of Attention Deficits in Epilepsy
Status: COMPLETED
Conditions: Epilepsy|Cognitive Deficits|Attention Deficits
Interventions: DRUG: Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transjugular Intrahepatic Portosystemic Shunt With 8- or 10-mm Covered Stents
Status: TERMINATED
Conditions: Cirrhosis
Interventions: DEVICE: TIPS created with 8 or 10 mm covered stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Median Nerve Hydrodissection by Hyalase Versus Midazolam in the Treatment of Carpal Tunnel Syndrome:
Status: UNKNOWN
Conditions: Pain, Neuropathic
Interventions: DRUG: hyalase group|DRUG: midazolam group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of an Antibody Against Zika Virus (Tyzivumab) in ZIKV Infected Patients
Status: WITHDRAWN
Conditions: Treatment of Acute Zika Virus Infection
Interventions: BIOLOGICAL: Tyzivumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Open Label Phase I Study To Evaluate the Safety of Combination Therapy With AZT and Interferon-Beta in Patients With AIDS Related Kaposi's Sarcoma
Status: COMPLETED
Conditions: Sarcoma, Kaposi|HIV Infections
Interventions: DRUG: Interferon beta-1b|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotics and Infections in Conscripts in Military Service
Status: COMPLETED
Conditions: Respiratory Tract Infections|Gastrointestinal Diseases|Asthma Exacerbations
Interventions: DIETARY_SUPPLEMENT: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Renin-angiotensin-system Blockade on Urinary Free Light Chains in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes|Hypertension
Interventions: DRUG: amlodipine, hydralazine, terazosin or hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder
Status: COMPLETED
Conditions: Bipolar I Depression
Interventions: DRUG: Armodafinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics of Jaktinib in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Jaktinib Hydrochloride Tablets|DRUG: Itraconazole capsule|DRUG: Rifampicin Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Faecal Microbiota Transplantation Against Chronic Diarrhea in Patients With Systemic Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Diarrhea|Systemic Sclerosis
Interventions: PROCEDURE: Faecal Microbiota Transplantation (FMT)|PROCEDURE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AccuCath™ Intravenous (IV) Device Used by Vascular Access Team (VAT)
Status: COMPLETED
Conditions: Vascular Access Complication
Interventions: DEVICE: AccuCath Intravenous Catheter System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Naltrexone and Clonidine Combination (ATNC05) in the Treatment of Chronic Back Pain
Status: COMPLETED
Conditions: Back Pain|Lower Back Pain|Cervical Pain
Interventions: DRUG: Naltrexone and Clonidine Combination|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fludarabine, Cytarabine, and Pegcrisantaspase for the Treament of Relapsed or Refractory Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Recurrent Acute Biphenotypic Leukemia|Recurrent Acute Lymphoblastic Leukemia|Recurrent Acute Myeloid Leukemia|Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Recurrent T-Cell Prolymphocytic Leukemia|Refractory Acute Biphenotypic Leukemia|Refractory Acute Lymphoblastic Leukemia|Refractory Acute Myeloid Leukemia|Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Refractory T-Cell Prolymphocytic Leukemia
Interventions: DRUG: Cytarabine|DRUG: Fludarabine|DRUG: Pegcrisantaspase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Analysis of the Efficacy of Instructional Videos and Live Demonstrations in Crown Preparation Training for Preclinical Dental Students
Status: COMPLETED
Conditions: Medical Education|Dental|Dental Crown Preparation|Instructional Methods|Training Effectiveness
Interventions: BEHAVIORAL: Group A (instructional video),|BEHAVIORAL: Group B (live demonstration)|BEHAVIORAL: Group C (hybrid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Determine the Safety, Tolerability, and Pharmacokinetic Profile of HPN-07 and HPN-07 Plus NAC
Status: COMPLETED
Conditions: Hearing Loss|Sensorineural Hearing Loss|Noise-Induced Hearing Loss
Interventions: DRUG: HPN-07|DRUG: NAC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ingenol Mebutate Gel 0.015% for Treatment of AK on the Face in Solid Organ Transplant Recipients
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: ingenol mebutate gel 0.015%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Transplantation From HLA Partially-Matched Related Donors for Patients With Hematologic Malignancies
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Acute Myelogenous Leukemia|Myelodysplastic Syndrome|Chronic Myelogenous Leukemia|Non-Hodgkin Lymphoma|Hodgkin Lymphoma
Interventions: RADIATION: Radiation|DRUG: Cyclophosphamide|BIOLOGICAL: Donor Lymphocyte Infusion (DLI)|BIOLOGICAL: Haploidentical Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Arterial Pressure Response During Exercise
Status: UNKNOWN
Conditions: COPD Patients|Healthy Subjects|Semi-supine Echo (SSE)|Flow-mediated Vasodilatation (FMD)|High Sensitive C-reactive Protein (hsCRP)
Interventions: OTHER: Measure pulmonary artery pressure change during exercise|OTHER: Pulmonary pressure response during exercise
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PP100-01 (Calmangafodipir) for Overdose of Paracetamol
Status: COMPLETED
Conditions: Paracetamol Overdose
Interventions: DRUG: PP100-01 (calmangafodipir)|DRUG: Acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Hematopoietic Cell Transplantation for Severe Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Scleroderma|Severe Systemic Sclerosis
Interventions: DRUG: fludarabine phosphate|DRUG: Mycophenolic Acid|DRUG: tacrolimus|RADIATION: total-body irradiation|PROCEDURE: bone marrow transplantation|PROCEDURE: reduced intensity allogeneic hematopoietic stem cell transplantation|PROCEDURE: quality-of-life assessment|OTHER: laboratory biomarker analysis|OTHER: flow cytometry|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety and Response of Fosbretabulin in Asian Patients With Polypoidal Choroidal Vasculopathy (PCV)
Status: COMPLETED
Conditions: Polypoidal Choroidal Vasculopathy
Interventions: DRUG: fosbretabulin|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Probiotics on Prevention of Atopy, Atopic Disease and Immunological Responses
Status: COMPLETED
Conditions: Eczema|Asthma|Allergic Rhinitis
Interventions: DIETARY_SUPPLEMENT: Probiotics|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of IV Tranexamic Acid on the Thromboelastogram in Patients Undergoing Total Hip or Knee Arthroplasty
Status: COMPLETED
Conditions: Status Post Total Hip and Knee Arthroplasty
Interventions: PROCEDURE: Effects of IV TXA on TEG in patients undergoing THA or TKA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Antioxidant Agents on the Number of DNA Double-strand Breaks After Radiation-based Cardiac Examinations
Status: COMPLETED
Conditions: Focus of the Study: DNA Damage Due to Medical Diagnostic X-ray
Interventions: RADIATION: Low-dose radiation exposure|RADIATION: High-dose radiation exposure|OTHER: No radiation exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of VAY736 in Patients With Primary Sjogren's Syndrome (pSS)
Status: COMPLETED
Conditions: Primary Sjogren Syndrome
Interventions: BIOLOGICAL: VAY736|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Combined Pressure and Silicone Intervention for Hypertrophic Scar Treatment
Status: UNKNOWN
Conditions: Cicatrix, Hypertrophic|Rehabilitation
Interventions: DEVICE: compression|DEVICE: occlusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Palonosetron IV to Prevent Postoperative Nausea and Vomiting in Pediatric Patients
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: palonosetron|DRUG: palonosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION