pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparison of Preoperative and Postoperative Radiotherapy and Capecitabine in Locally Advanced Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: RADIATION: Preoperative chemoradiotherapy|RADIATION: Postoperative chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Ventilator Mode During the Night: New Strategy of Mechanical Ventilation Weaning
Status: COMPLETED
Conditions: Weaning Failure|COPD Exacerbation
Interventions: OTHER: pressure support ventilation|OTHER: Pressure controlled ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Gene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids
Status: COMPLETED
Conditions: Healthy|Modeling Psychosis
Interventions: DRUG: delta-9-tetrahydrocannabinol|DRUG: Cannabidiol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pilot Study of Mirabegron and Behavioral Modification Including Pelvic Floor Exercise for Overactive Bladder in Parkinson's Disease (MAESTRO)
Status: COMPLETED
Conditions: Parkinsons Disease
Interventions: DRUG: Mirabegron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Shared Decision Making Between Patients and GPs in the Treatment of Type 2 Diabetes in Primary Care.
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Shared decision making
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aromatase Inhibitors or GnRH-a for Uterine Adenomyosis
Status: COMPLETED
Conditions: the Efficacy of Aromatase Inhibitor vs. Gonadotrpins Releasing Hormone Agonists in Treating Premenopausal Women With Uterine Adenomyosis
Interventions: DRUG: received oral letrozole (2.5 mg/day)and goserelin subcutaneosly (3.6 mg/month)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a Novel Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 14 Years in Asia
Status: COMPLETED
Conditions: Dengue|Dengue Fever|Dengue Hemorrhagic Fever
Interventions: BIOLOGICAL: Live, attenuated, dengue serotype 1, 2, 3, 4 virus|BIOLOGICAL: Placebo: Sodium chloride (NaCl) 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intralesional Treatment With Interleukin-2 (Proleukin) in Soft Tissue Melanoma Metastases
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Interleukin-2 (Proleukin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Tailored Electronic Reminders on Compliance With Removable Orthodontic Retention
Status: COMPLETED
Conditions: Retention|Compliance|Orthodontic|Periodontal Health
Interventions: OTHER: Electronic reminder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MORbidity PRevalence Estimate In StrokE
Status: UNKNOWN
Conditions: Stroke|CVA (Cerebrovascular Accident)|CVA; Sequelae|Stroke, Ischemic|Stroke Hemorrhagic|Hemianopia|Hemiplegia|Hemiparesis|Aphasia|Cerebral Infarction|Intracerebral Hemorrhage|Anxiety|Depression|Dysphagia|Dysarthria|Hemispatial Neglect|Mild Cognitive Impairment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Amoxicillin-clavulanate in Treating Acute Otitis Media Evaluated by Daily Tympanometry
Status: COMPLETED
Conditions: Otitis Media, Suppurative
Interventions: DRUG: Amoxicillin-clavulanate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The KetoGlioma (Ketogenic Glioma) Study
Status: WITHDRAWN
Conditions: Glioma
Interventions: DIETARY_SUPPLEMENT: Supplemental High Fat Low Carbohydrate (sHFLC) + KetoPhyt
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phototherapy and Mogamulizumab in Early Stage MF (PLIGHT)
Status: RECRUITING
Conditions: Mycosis Fungoides
Interventions: DRUG: Mogamulizumab-Kpkc|DEVICE: Phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analysis of Change of Optic Nerve Sheath Diameter in Robot Assisted Laparoscopic Radical Prostatectomy
Status: COMPLETED
Conditions: Optic Nerve Sheath Diameter|Robot Assisted Laparoscopic Radical Prostatectomy
Interventions: DRUG: Desflurane|DRUG: propofol|DRUG: remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab (BMS-936558; MDX-1106) in Combination With Sunitinib, Pazopanib, or Ipilimumab in Subjects With Metastatic Renal Cell Carcinoma (RCC) (CheckMate 016)
Status: COMPLETED
Conditions: Renal Cell Carcinoma|Clear-cell Metastatic Renal Cell Carcinoma
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: Pazopanib|DRUG: Sunitinib|BIOLOGICAL: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations Original Study
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DEVICE: Magstim Rapid 2 system triggering Magstim Super Rapid system|DEVICE: Magstim Rapid-2 system triggering Magstim Super Rapid system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Metastatic Advanced Pancreas Sorafenib
Status: UNKNOWN
Conditions: Locally Advanced Pancreatic Cancer
Interventions: DRUG: Sorafenib 400 mg po bid, continuously|DRUG: Gemcitabina, Cisplatino
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pneumoperitoneum Management With Low vs. Higher Pressure
Status: WITHDRAWN
Conditions: Malignant Neoplasms of Female Genital Organs
Interventions: BEHAVIORAL: Questionnaires|DEVICE: Conventional Insufflation System (CIS)|DEVICE: ConMed AirSeal Insufflation System (AIS) at Low Pressure|DEVICE: ConMed AirSeal Insufflation System (AIS) at Higher Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Linsitinib or Topotecan Hydrochloride in Treating Patients With Relapsed Small Cell Lung Cancer
Status: COMPLETED
Conditions: Recurrent Small Cell Lung Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Linsitinib|OTHER: Pharmacological Study|DRUG: Topotecan Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Evolocumab on Platelet Reactivity in Patients With Diabetes Mellitus
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2|Dyslipidemia Associated With Type II Diabetes Mellitus|Percutaneous Coronary Intervention
Interventions: DRUG: Evolocumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Randomized-controlled Trial of the Effectiveness of COVID-19 Early Treatment in Community
Status: COMPLETED
Conditions: Treatment Efficacy
Interventions: DRUG: FluvoxaMINE Maleate 50 MG|COMBINATION_PRODUCT: Fluvoxamine, Bromhexine|COMBINATION_PRODUCT: Fluvoxamine, Cyproheptadine|DRUG: Niclosamide Pill|COMBINATION_PRODUCT: Niclosamide, Bromhexine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects on Lipid Metabolism of Olive Extracts Rich in Polyphenols
Status: UNKNOWN
Conditions: Cholesterol; Metabolic Disorder|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Olive polyphenols|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2, Multi-center, Open-label, Dose-finding Trial to Investigate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of OPC-41061 in Patients With Chronic Renal Failure Undergoing Hemodialysis or Hemodiafiltration
Status: COMPLETED
Conditions: Chronic Renal Failure
Interventions: DRUG: OPC-41061
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: D-Cycloserine Enhancement of Exposure-Based CBT for Smoking Cessation (DCSSmoking)
Status: WITHDRAWN
Conditions: Smokers
Interventions: DRUG: D-cycloserine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Erector Spinae Plane Block and Intravenous Patient-controlled Analgesia in Percutaneous Nephrolithotomy
Status: COMPLETED
Conditions: Nephrolithiasis|Percutaneous|Analgesia|PCA
Interventions: PROCEDURE: Bupivakain + deksametazon Adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Prophylactic Effect Between Acupuncture and Acupressure on Menstrual Migraine
Status: UNKNOWN
Conditions: Menstrual Migraine
Interventions: PROCEDURE: verum acupuncture|PROCEDURE: acupressure|PROCEDURE: control acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Acute Effects of an Isometric Loading Intervention on Lower Extremity Landing Biomechanics in Individuals With Patellar Tendinopathy
Status: COMPLETED
Conditions: Tendinopathy
Interventions: OTHER: Isometric Exercise|OTHER: Sham Transcutaneous Electrical Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Participants Investigating the Effect of TMC435 on the Pharmacokinetics of Immunosuppressants Cyclosporine and Tacrolimus
Status: COMPLETED
Conditions: Hepatitis C Virus
Interventions: DRUG: tacrolimus|DRUG: TMC435|DRUG: cyclosporine|DRUG: TMC435
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of 360 Video and MAPS on Enrollment in the DPP
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|PreDiabetes
Interventions: BEHAVIORAL: Mobile 360° Video intervention|BEHAVIORAL: Motivation and Problem Solving (MAPS)|BEHAVIORAL: Risk notification/education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Microcurrents Therapy in Pressure Ulcers in Elderly People
Status: COMPLETED
Conditions: Electric Stimulation Therapy
Interventions: DEVICE: Care protocol plus microcurrents|DEVICE: Care protocol plus placebo microcurrents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compassion Meditation for Cancer Survivor-Caregiver Dyads
Status: COMPLETED
Conditions: Cancer Survivors|Informal Cancer Caregivers (Family and Friends of Cancer Survivors)
Interventions: BEHAVIORAL: Cognitively-Based Compassion Training|BEHAVIORAL: CHE (Cancer Health Education)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Adaptive CRT Effect on Electrical Dyssynchrony
Status: COMPLETED
Conditions: Cardiomyopathy|Heart Failure|Left Bundle Branch Block
Interventions: DEVICE: Adaptive cardiac resynchronization therapy|DEVICE: Conventional Cardiac Resynchronization Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of RAD001 and Bevacizumab in Recurrent Ovarian, Peritoneal, and Fallopian Tube Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Carcinoma
Interventions: DRUG: RAD001|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A-dmDT390-bisFv(UCHT1) Fusion Protein in Combination With Ionizing Radiation for Treatment of Stage IV Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: A-dmDT390-bisFv(UCHT1) (Resimmune®)|RADIATION: Ionizing Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of the Effects of a SWalker II and VR for Hip Fracture Rehabilitation in the Elderly
Status: ENROLLING_BY_INVITATION
Conditions: Hip Fractures|Gait Disorders in Old Age
Interventions: OTHER: Preliminary Phase|OTHER: Phase I - Early gait rehabilitation|OTHER: Phase II - Maintenance gait function ( with VR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Narrative Intervention for Chronic Illness- Heart Failure Trial (NICI-HF)
Status: NOT_YET_RECRUITING
Conditions: Heart Failure|Heart Failure NYHA Class III|Heart Failure NYHA Class IV
Interventions: BEHAVIORAL: Narrative Intervention for Chronic Illness-Heart Failure|OTHER: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultrasound-Guided Landmark and Epidural Site Pain
Status: COMPLETED
Conditions: Back Pain|Epidural Analgesia, Obstetric
Interventions: PROCEDURE: US-epidural SVD|PROCEDURE: US sham- epidural SVD|PROCEDURE: Spontaneous vaginal delivery without an Epidural
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Bevacizumab and Irinotecan or Temozolomide in Treating Patients With Recurrent or Refractory Glioblastoma Multiforme or Gliosarcoma
Status: COMPLETED
Conditions: Adult Glioblastoma|Adult Gliosarcoma|Recurrent Adult Brain Neoplasm
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Irinotecan Hydrochloride|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer
Status: RECRUITING
Conditions: Low Grade Serous Ovarian Cancer
Interventions: DRUG: avutometinib|DRUG: Defactinib|DRUG: Pegylated liposomal doxorubicin|DRUG: Paclitaxel|DRUG: Topotecan|DRUG: Letrozole|DRUG: Anastrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: FOLFIRI regimen|DRUG: fluorouracil|DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium|DRUG: semaxanib
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Irreparable Rotator Cuff Tears Treatment. Comparison of Two Methods: With and Without Biceps Tendon Augmentation
Status: UNKNOWN
Conditions: Massive Rotator Cuff Tears|Rotator Cuff Injuries|Shoulder Pain Chronic
Interventions: PROCEDURE: Arthroscopic partial repair of massive rotator cuff tear|PROCEDURE: Arthroscopic partial repair of rotator cuff with biceps augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Examine the Safety and Efficacy of a New Drug in Patients With Symptoms of Overactive Bladder (OAB)
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: vibegron|DRUG: Vibegron placebo|DRUG: Tolterodine Tartrate ER|DRUG: Tolterodine placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of LX9211 in Participants With Postherpetic Neuralgia
Status: COMPLETED
Conditions: Postherpetic Neuralgia
Interventions: DRUG: Placebo|DRUG: LX9211
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Vitamin D in Neuroinflammatory on Drug Resistant Epilepsy
Status: RECRUITING
Conditions: Drug Resistant Epilepsy
Interventions: DRUG: Cholecalciferol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of the Efficacy and Safety of Raphamin in Combined Treatment of Community-acquired Pneumonia
Status: RECRUITING
Conditions: Community-acquired Pneumonia|Pneumonia
Interventions: DRUG: Raphamin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Ultrasound Images in Brain Tumour Surgery With the Use of an Acoustic Coupling Fluid Mimicking Brain Tissue.
Status: TERMINATED
Conditions: Brain Neoplasms|Glioma
Interventions: BIOLOGICAL: acoustic coupling fluid|BIOLOGICAL: Ringer's acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Cefprozil 500 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cefzil® 500 mg tablets|DRUG: Cefprozil 500 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Exosome-based Nanoplatform for Ldlr mRNA Delivery in FH
Status: NOT_YET_RECRUITING
Conditions: Familial Hypercholesterolemia
Interventions: BIOLOGICAL: Low Density Lipoprotein Receptor mRNA Exosomes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Intensity Interval Training or Strength Training in Women With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: BEHAVIORAL: strength training|BEHAVIORAL: interval training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate Efficacy and Safety of Nitazoxanide in the Treatment of Colds Due to Enterovirus/Rhinovirus Infection
Status: RECRUITING
Conditions: Enterovirus|Rhinovirus
Interventions: DRUG: Nitazoxanide|DRUG: Placebo|DIETARY_SUPPLEMENT: Vitamin Super B-Complex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Relamorelin in Diabetic Gastroparesis Study 03
Status: TERMINATED
Conditions: Gastroparesis|Diabetes Mellitus
Interventions: DRUG: Placebo|DRUG: Relamorelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chronic Pulmonary Aspergillosis and Ambisome Aerosol With Itraconazole
Status: RECRUITING
Conditions: Chronic Pulmonary Aspergillosis
Interventions: DRUG: inhaled Ambisome®|DRUG: inhaled placebo|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Apathy in Dementia Methylphenidate Trial (ADMET)
Status: COMPLETED
Conditions: Apathy|Alzheimer's Disease
Interventions: DRUG: Methylphenidate|DRUG: placebo|OTHER: Psychosocial intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fasting Bioequivalence Study of 2 Metformin 1000 mg Prolonged Release Tablets in 28 Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Metformin 1000 mg Prolonged Release Tablets (JSC Farmak, Ukraine)|DRUG: Glucophage® XR 1000 mg Prolonged Release Tablets (Merck Serono Ltd, UK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Biomarkers in Tissue Samples From Young Patients With Liver Cancer
Status: COMPLETED
Conditions: Childhood Hepatoblastoma|Stage I Childhood Liver Cancer|Stage II Childhood Liver Cancer|Stage III Childhood Liver Cancer|Stage IV Childhood Liver Cancer
Interventions: GENETIC: RNA analysis|GENETIC: gene expression analysis|GENETIC: microarray analysis|GENETIC: nucleic acid sequencing|OTHER: diagnostic laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Compare the Effects of Exenatide and Sitagliptin on Postprandial Glucose in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: exenatide|DRUG: sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Selpercatinib (LY3527723) in Participants With Advanced Solid Tumors Including RET Fusion-positive Solid Tumors, Medullary Thyroid Cancer and Other Tumors With RET Activation
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor|Medullary Thyroid Cancer
Interventions: DRUG: Selpercatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Erlotinib in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor Mutations
Status: COMPLETED
Conditions: Non-Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Education Bundle to Decrease Patient Refusal of VTE Prophylaxis
Status: COMPLETED
Conditions: Venous Thromboembolism|Deep Venous Thrombosis|Pulmonary Embolism
Interventions: BEHAVIORAL: Patient-centered education bundle
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Efficacy of Self-directed & Therapist-assisted Telehealth Parent Training Intervention for Children With ASD
Status: TERMINATED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: ImPACT Online
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Effectiveness and Safety Study of CONCERTA* vs. Immediate Release Methylphenidate (IR MPH) in Attention Deficit Hyperactivity Disorder Children
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: OROS*-Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of "O" Shaped- Endotracheal Tube During Intubation for General Anesthesia: Prospective Randomized Trial
Status: UNKNOWN
Conditions: Endotracheal Intubation
Interventions: OTHER: group "O"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Luteal Phase Support With Estradiol In Poor Responders Undergoing In Vitro Fertilization
Status: UNKNOWN
Conditions: ICSI
Interventions: DRUG: Estradiol Valerate|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Confirmatory Study of K-877 (Pemafibrate) in Patients With Hypercholesterolemia and Statin Intolerance
Status: RECRUITING
Conditions: Hypercholesterolemia
Interventions: DRUG: K-877 0.2 mg/day (once daily)|DRUG: K-877 0.4 mg/day (once daily)|DRUG: Placebo (once daily)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Scar Mobilization Techniques vs Core Stability Exercises on Scar Tissue and Lumbopelvic Pain
Status: COMPLETED
Conditions: Scar Tissue|Back Pain
Interventions: OTHER: Scar mobilization techniques|OTHER: Core stabilization exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Creatine and Tamoxifen in Volunteers With Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: creatine|DRUG: tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Safety and Therapeutic Activity of THOR-707 in Adult Subjects With Advanced or Metastatic Solid Tumors (THOR-707-101)
Status: RECRUITING
Conditions: Metastasis
Interventions: DRUG: THOR-707|DRUG: Checkpoint inhibitor|DRUG: anti-EGFR antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography/Magnetic Resonance Imaging in Patients
Status: TERMINATED
Conditions: Colon Cancer|Head and Neck Cancer|Lung Cancer|Lymphoma|Malignant Neoplasm|Melanoma|Unspecified Adult Solid Tumor, Protocol Specific|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DEVICE: magnetic resonance imaging with positron emission tomography scanning
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Trial of the Use of Anakinra in Cytokine Storm Syndrome Secondary to Covid-19 (ANA-COVID-GEAS)
Status: COMPLETED
Conditions: COVID-19 Pnemonia
Interventions: DRUG: Anakinra 149 MG/ML Prefilled Syringe [Kineret]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Questionnaires and Feedback on the Patient Compliance for Endoscopic Surveillance After ESD
Status: RECRUITING
Conditions: Patient Compliance
Interventions: BEHAVIORAL: Questionnaire|BEHAVIORAL: Questionnaire without compliance-related education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Camrelizumab Plus Apatinib and Temozolomide as Neoadjuvant in High Risk Acral Melanoma
Status: RECRUITING
Conditions: Melanoma|Acral Melanoma|Temozolomide|Apatinib|Camrelizumab|Neoadjuvant|Pathological Response
Interventions: DRUG: Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Supplementation of a Probiotic, B. Longum, on BMI and Anthropometric Outcomes in Overweight/Obese Adults.
Status: UNKNOWN
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Bifidobacterium longum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Roflumilast in Prevention of Peripheral Neuropathy
Status: NOT_YET_RECRUITING
Conditions: Peripheral Neuropathy
Interventions: DRUG: Roflumilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Benefit of Expanded Surveillance of Nursing Homes During the COVID-19 Pandemic
Status: COMPLETED
Conditions: COVID-19 Respiratory Infection|SARS-CoV-2 Infection
Interventions: DIAGNOSTIC_TEST: Nasopharyngeal swab for SARS-CoV-2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevention of Post-Operative Nausea and Vomiting With Propofol Infusion
Status: RECRUITING
Conditions: Post-operative Nausea and Vomiting
Interventions: DRUG: Propofol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Cluster Randomized Trial to Evaluate Long Lasting Insecticidal Hammocks to Prevent Forest Malaria in Vietnam
Status: COMPLETED
Conditions: Malaria
Interventions: OTHER: Hammocks with LLIN|OTHER: Standard vector control measures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Management of Narrow Alveolar Ridges Via Densah-bur Versus Piezoelectric
Status: COMPLETED
Conditions: Knife Edge Alveolar Ridge
Interventions: PROCEDURE: Ridge expansion by osseodensifcation/Ridge expansion by ridge splitting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Empagliflozin Tablet in Healthy Participants.
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Empagliflozin Tablets|DRUG: Empagliflozin Tab 25 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy Study for Surgically Resected Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: HyperAcute-Pancreas Immunotherapy|DRUG: Gemcitabine|RADIATION: 5FU Chemoradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The OPTIMA-5 Trail
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Recombinant Staphylokinase|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetic First in Human (FIH) Study of Intravenous (IV) TKM-100201 Infusion
Status: TERMINATED
Conditions: Ebola Virus Infection
Interventions: DRUG: TKM-100201|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Optimal Time Delay of Epinephrine Injection With "One-per-mil" Tumescent Solution
Status: UNKNOWN
Conditions: Ischemia
Interventions: PROCEDURE: "One-per-mil" Tumescent Solution Injection|PROCEDURE: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemoprevention of Colorectal Cancer: the Role of Non-digestible Carbohydrates
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: Maltodextrin and Amioca starch|DIETARY_SUPPLEMENT: Hi-maize 260|DIETARY_SUPPLEMENT: Polydextrose|DIETARY_SUPPLEMENT: Hi-maize 260 and polydextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Long-Term Extension Study of WA19926 on the Safety of Tocilizumab (RoActemra/Actemra) in Participants With Early Moderate to Severe Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of the Combination Immunotherapy Regimen: SX-682, TriAdeno Vaccine, Retifanlimab and IL-15 Agonist N-803 (STAR15) for Metastatic Colorectal Cancer (mCRC)
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Retifanlimab|BIOLOGICAL: Therapeutic CEA, Brachyury and MUC1 TriAdeno Vaccine Platform|DRUG: N-803|DRUG: SX-682
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sofosbuvir Containing Regimens for the Treatment of Chronic HCV Infection in Participants With Chronic Genotype 1, 2, 3, or 6 HCV Infection
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: LDV/SOF|DRUG: SOF|DRUG: RBV|DRUG: Peg-IFN|DRUG: GS-9669|DRUG: VEL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Pharmacokinetic and Safety Profiles of Different Formulations of SHR-1314 After Subcutaneous Injection in Healthy Subjects
Status: UNKNOWN
Conditions: Pharmacokinetic
Interventions: DRUG: SHR-1314
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Different Remineralization Agents on Molar Incisor Hypomineralization Defects: a Randomized Clinical Study
Status: RECRUITING
Conditions: Molar Incisor Hypomineralization
Interventions: OTHER: Fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Pharmacokinetics of C3G and to Estimate Antioxidative Markers After Repeated Administration of Black Bean Seed Coat Extract
Status: COMPLETED
Conditions: Oxidative Stress
Interventions: OTHER: Black bean seed coat extract
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Study in Healthy Adults to Evaluate Pharmacokinetics, Safety and Tolerability of ABT-450 With Ritonavir
Status: COMPLETED
Conditions: HCV Infection
Interventions: DRUG: ABT-450|DRUG: ritonavir|DRUG: Placebo for ABT-450|DRUG: Placebo for ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Local Registration Trial in China Humalog Mix 50
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DRUG: Humalog Mix 50|DRUG: Human Insulin Mix 50:50
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Efficacy of Botulinum Toxin Type A in Patients With Cervical Dystonia
Status: COMPLETED
Conditions: Cervical Dystonia
Interventions: BIOLOGICAL: botulinum toxin type A|BIOLOGICAL: botulinum toxin type A Formulation 2|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aesthetic Outcome of Intra-dermal Versus Transcutaneous Purse-string Closure
Status: ENROLLING_BY_INVITATION
Conditions: Scarring
Interventions: PROCEDURE: Intra-dermal purse-string closure|PROCEDURE: Transcutaneous purse-string closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: MSOT Using Cetuximab-800CW for Detection of Cervical Lymph Node Metastases
Status: UNKNOWN
Conditions: Oral Cancer|Lymph Node Metastases
Interventions: DEVICE: MSOT Acuity Echo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Biomarkers of Theta Burst Stimulation in Major Depressive Disorder
Status: UNKNOWN
Conditions: Depressive Disorder, Treatment-Resistant
Interventions: DEVICE: Theta Burst Stimulation ( Transcranial Magnetic Stimulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Cryopreserved vs. Liquid Platelets Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Surgical Blood Loss|Hemorrhage
Interventions: BIOLOGICAL: Cryopreserved platelets|BIOLOGICAL: Liquid-stored platelets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Anthocyanin Mouthrinse for Oral Anti-inflammation From Orthodontic Treatment
Status: COMPLETED
Conditions: Inflammation of Mouth|Acute Mucous Inflammation
Interventions: DRUG: Anthocyanin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fixation of Displaced Distal Ulna Fractures in Adults by Flexible Intramedullary Nail
Status: UNKNOWN
Conditions: Fixation of Displaced Distal Ulna Fractures in Adults by Flexible Intramedullary Nail
Interventions: DEVICE: Flexible intramedullary nail
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Suprachoroidal Hemorrhage Associated With Pars Plana Vitrectomy
Status: COMPLETED
Conditions: Suprachoroidal Hemorrhage (Diagnosis)|Pars Plana Vitrectomy
Interventions: PROCEDURE: Suprachoroidal hemorrhage associated with pars plana vitrectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics, Safety, and Efficacy of ASTX727 in Combination With Venetoclax in Acute Myeloid Leukemia (AML)
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Decitabine and Cedazuridine (ASTX727)|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Tisotumab Vedotin Monotherapy & in Combination With Other Cancer Agents in Subjects With Cervical Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: Tisotumab Vedotin|DRUG: Bevacizumab|DRUG: Pembrolizumab|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: National Ophthalmic Genotyping and Phenotyping Network (eyeGENE(R)), Stage 3-Expansion of DNA and Data Repositories for Rare Inherited Ophthalmic Diseases
Status: NOT_YET_RECRUITING
Conditions: Adrenocortical Carcinoma (ACC)|Recurrent Adrenocortical Carcinoma (ACC)|Recurrent Abdominal Adrenocortical Carcinoma (ACC)|Carcinoma, Adrenocortical|Carcinoma, Adrenal Cortical
Interventions: RADIATION: Preoperative external beam radiation therapy (EBRT)|PROCEDURE: Surgical resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study About the Evolution of Severe Late Onset Pompe Disease Patient With Pulmonary Dysfunction and Receiving Myozyme®
Status: COMPLETED
Conditions: Pompe Disease (Late-Onset)|Glycogen Storage Disease Type II (GSD II)|Glycogenesis 2 Acid Maltase Deficiency
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Inspiratory Muscle Training in Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Respiration; Decreased
Interventions: DEVICE: Threshold (IMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Engineering Immune Organoids to Study Pediatric Cancer
Status: RECRUITING
Conditions: Brain Tumor|Kidney Tumor|Neuroblastoma|Sarcoma
Interventions: PROCEDURE: Skin biopsy|PROCEDURE: Fresh tumor sample|BIOLOGICAL: Blood sample|PROCEDURE: Healthy tissue from the tumor|PROCEDURE: Spinal cerebrospinal fluid (SCF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety Study of Squalamine Ophthalmic Solution in Subjects With Neovascular AMD
Status: UNKNOWN
Conditions: Age-related Macular Degeneration
Interventions: DRUG: Squalamine lactate ophthalmic solution, 0.2%|DRUG: Placebo Ophthalmic solution|DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of LVGN6051 (CD137 Agonist Antibody) in Advanced or Metastatic Malignancy
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: LVGN6051|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selinexor as Single Agent and With Imatinib in Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (SeliGIST)
Status: ACTIVE_NOT_RECRUITING
Conditions: Maximum Tolerated Dose|GIST|Metastatic Adult Soft Tissue Sarcoma|Drug Toxicity|Drug Use
Interventions: DRUG: Selinexor|DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccination Against Influenza H1N1 in Rheumatic Diseases
Status: UNKNOWN
Conditions: Influenza|Rheumatic Diseases
Interventions: BIOLOGICAL: Focetria (Monovalent MF59-Adjuvanted vaccine)|BIOLOGICAL: Focetria (Monovalent MF59-Adjuvanted vaccine)|BIOLOGICAL: Focetria (Monovalent MF59-Adjuvanted vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Career Management to Improve Education, Employment and Retention for People With Anxiety and Depression
Status: COMPLETED
Conditions: Anxiety|Depression
Interventions: BEHAVIORAL: Individual Career Management (ICM)|BEHAVIORAL: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Ridge Expansion by Osseodensification Simultaneously With Implant Placement in Narrow Alveolar Ridges
Status: UNKNOWN
Conditions: Alveolar Ridge Augmentation
Interventions: PROCEDURE: Ridge Expansion by ossedensification|PROCEDURE: ridge expansion by ridge splitting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Brain and Heart Glucose Metabolism in Alcohol Use Disorder
Status: ENROLLING_BY_INVITATION
Conditions: Alcohol Use Disorder (AUD)|Alcohol Drinking
Interventions: DIETARY_SUPPLEMENT: Ketone Ester "(R)-3-hydroxybutyl (R)-3-hydroxybutyrate"|DRUG: FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Impact of the "PROactive Telecoaching Program" on Physical Activity in Patients With COPD.
Status: WITHDRAWN
Conditions: COPD
Interventions: DEVICE: Automated telehealth system|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of Patient-reported Goal Attainment in the Treatment of Female Overactive Bladder
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: Tolterodine extended-release (ER) 4mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Shengdi Dahuang Decoction in the Treatment of Acute Hemorrhagic Stroke
Status: UNKNOWN
Conditions: Hemorrhagic Stroke
Interventions: DRUG: Granules of Shengdi Dahuang Decoction|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Access Program (EAP) of Gilteritinib (ASP2215) in Patients With FMS-like Tyrosine Kinase 3 (FLT3) Mutated Relapsed or Refractory Acute Myeloid Leukemia (AML) or With FLT3-Mutated AML in Complete Remission (CR) With Minimal Residual Disease (MRD)
Status: NO_LONGER_AVAILABLE
Conditions: Acute Myeloid Leukemia (AML)|FMS-like Tyrosine Kinase-3 (FLT3) Mutations
Interventions: DRUG: gilteritinib
Study Type: EXPANDED_ACCESS