pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A DDI Study to Investigate PK and Safety of Cefiderocol in Combination With Xeruborbactam in Healthy Adult Participants
Status: NOT_YET_RECRUITING
Conditions: Bacterial Infections
Interventions: DRUG: Xeruborbactam|DRUG: Cefiderocol|DRUG: Xeruborbactam/Cefiderocol|DRUG: Dextrose 5% in water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Resveratrol on Brain Function and Structure
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: resveratrol supplementation|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dentoskeletal Changes In The Transverse Dimension Using Tooth Bone-Borne Vs. Bone-Borne Expansion Appliances
Status: COMPLETED
Conditions: Transverse Maxillary Deficiency
Interventions: DEVICE: skeletal anchorage and rapid palatal expansion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Antimicrobial Overuse Through Targeted Therapy for Patients With Community-Acquired Pneumonia
Status: RECRUITING
Conditions: Community-Acquired Pneumonia|Antimicrobial Stewardship|Point-of-Care Testing
Interventions: DIAGNOSTIC_TEST: Rapid Diagnostic Testing|OTHER: Pharmacist-led de-escalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study Evaluating the Safety and Efficacy of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab, With or Without Platinum-Based Chemotherapy, in Participants With Previously Untreated Locally Advanced Resectable Stage II, IIIA, or Select IIIB Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: Atezolizumab|DRUG: Tiragolumab|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Pemetrexed|DRUG: Gemcitabine|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Effects of ACBT and AUTOGENIC DRAINAGE in Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Active cycle of breathing technique|OTHER: Autogenic drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: NSAIDS Versus Opioids in Acute SER II Ankle Fractures
Status: COMPLETED
Conditions: Ankle Fracture
Interventions: DRUG: Ibuprofen|DRUG: Acetaminophen/hydrocodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Upper Airway Collapsibility Evaluation in Different Sedative Levels by Sleep Endoscopy
Status: UNKNOWN
Conditions: Bronchoscopy|Obstructive Sleep Apnea|Conscious Sedation
Interventions: DEVICE: Sleep endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hemodynamic Effects of Two Modalities of Alveolar Recruitment Maneuvers - ICU Patients
Status: UNKNOWN
Conditions: Cardiac Output|Hemodynamic Optimization|Monitoring Blood Pressure|Stroke Volume|Mechanical Ventilation|Acute Respiratory Distress Syndrome
Interventions: PROCEDURE: Alveolar Recruitment Maneuver (ARM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetic Study of Clarithromycin in Very Low Birth Weight (VLBW)
Status: TERMINATED
Conditions: Very Low Birth Weight Infant|Ureaplasma/Mycoplasma Positive
Interventions: DRUG: Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Heidelberg Edge Perimetry (HEP) Detecting Glaucomatous Visual Field Defects
Status: COMPLETED
Conditions: Glaucoma
Interventions: DIAGNOSTIC_TEST: Heidelberg Edge Perimeter|DIAGNOSTIC_TEST: Octopus Visual Field|DIAGNOSTIC_TEST: Optical Coherence Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation the Pharmacokinetics,Safety,Tolerability of Single Intravitreal Injection RC28-E in Subjects With Wet Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: BIOLOGICAL: RC28-E
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Exposure Therapy for Speech Anxiety Using Commercial Hardware and Software
Status: COMPLETED
Conditions: Social Phobia|Anxiety|Behavior Therapy
Interventions: BEHAVIORAL: Face-to-face Virtual Reality Exposure Therapy|BEHAVIORAL: Internet-administered Virtual Reality Exposure Therapy|OTHER: Waiting-list
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Treatment Effect of Chinese Medicine and Western Medicine on Depression in China and America
Status: UNKNOWN
Conditions: Depression
Interventions: DRUG: Chinese herbs|PROCEDURE: acupuncture|OTHER: Psychotherapy|DEVICE: Transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PCT REveals Good Recovery After Acute Diverticulitis: the PREGRAD Study
Status: UNKNOWN
Conditions: Acute Diverticulitis
Interventions: PROCEDURE: Measure PCT, CRP and WBC at admission|PROCEDURE: Measure PCT, CRP and WBC 1 day after admission|PROCEDURE: Measure PCT, CRP and WBC 2 days after admission
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Oral Sildenafil Citrate to Improve Maternal and Neonatal Outcomes in Low-resource Settings
Status: NOT_YET_RECRUITING
Conditions: Intrapartum Fetal Distress|Neonatal Asphyxia|Intrapartum Asphyxia|Instrumental Delivery; Affecting Fetus
Interventions: DRUG: Sildenafil 50 mg Oral Tablet|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treg Cell Therapy in Liver and Kidney Transplantation - Preclinical Validation of Batches of Treg Cells Amplified in Vitro
Status: NOT_YET_RECRUITING
Conditions: Kidney Transplantation|Liver Transplantation
Interventions: OTHER: Lymphapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Morphine, Tramadol, and Ketorolac on Postoperative Stress and Immune Responses
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Intravenous morphine sulphate|DRUG: Intravenous tramadol HCL|DRUG: Intravenous ketorolac tromethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: An Investigational Device (Millar Mikro-Tip Catheter) and Imaging Scan (Shear Wave Elastography) in Measuring Tumor Pressure and Stiffness in Patients With Solid Tumors Undergoing Ultrasound-Guided Biopsy
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Neoplasm
Interventions: DEVICE: Shear Wave Elastography|PROCEDURE: Tumor Interstitial Fluid Pressure Measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Community Care Intervention to Decrease COVID-19 Vaccination Inequities
Status: RECRUITING
Conditions: COVID-19 Vaccination
Interventions: BEHAVIORAL: Community Health Worker Intervention to Enhance Vaccination Behavior (CHW-VB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Unstimulated Whole Saliva Flow During and After Radiotherapy, With the Use HcT20
Status: COMPLETED
Conditions: Abnormalities, Radiation-Induced
Interventions: OTHER: Mouthrinse with HcT20
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study With QR-504a to Evaluate Safety, Tolerability & Corneal Endothelium Molecular Biomarker(s) in Subjects With FECD3
Status: WITHDRAWN
Conditions: Fuchs Endothelial Corneal Dystrophy|FECD3|Corneal Diseases|LRS|Descemet's Membrane Disorder
Interventions: DRUG: QR-504a
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effects of Canagliflozin (JNJ-28431754) on Renal Endpoints in Adult Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Albuminuria
Interventions: DRUG: Placebo|DRUG: Canagliflozin, 100 mg|DRUG: Canagliflozin, 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the of OPC-34712 in Subjects With Normal Hepatic Function and Hepatically Impaired Subjects
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: OPC-34712
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Prevent Cartilage Damage Following Acute Knee Injury.
Status: COMPLETED
Conditions: Knee Injury
Interventions: DRUG: Anakinra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Therapy for Chronic Neck Pain.
Status: UNKNOWN
Conditions: Neck Pain, Posterior
Interventions: OTHER: Capacitive and Resistive Radiofrequency therapy|OTHER: Exercise therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Spinal Sealant System During Spinal Surgery
Status: COMPLETED
Conditions: Spine Surgery|Excessive Repair|Spinal Cord Injuries|Complication of Surgical Procedure
Interventions: DEVICE: Spinal Sealant|PROCEDURE: Standard Methods of Closing of the Dura
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Treating HCV at a Psychiatrist-staffed Outpatient Addiction Clinic
Status: COMPLETED
Conditions: Hepatitis C, Chronic|Hepatitis C|Opiate Dependence
Interventions: DRUG: sofosbuvir/velpatasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Community Intervention for HIV Testing & Care Linkage Among Young MSM in Bulgaria
Status: ACTIVE_NOT_RECRUITING
Conditions: Acquired Immunodeficiency Syndrome|HIV
Interventions: BEHAVIORAL: Social Network Leader Endorsement|BEHAVIORAL: HIV Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Children
Status: COMPLETED
Conditions: Pandemic H5N1 Influenza
Interventions: BIOLOGICAL: Adjuvanted H5N1 pandemic influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Lipid Infusion in Dialysis Patients With Endotoxemia
Status: COMPLETED
Conditions: Fatigue|End Stage Renal Disease (ESRD)
Interventions: DRUG: Lipidose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Melatonin and Vaccine Response, Immunity, and Chronobiology Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Vaccine Response|Sleep|Circadian Rhythm Disorders
Interventions: DIETARY_SUPPLEMENT: Melatonin|DEVICE: Phillips Actiwatch Spectrum Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Caries Prevention Potential of Pearl Powder Versus CPP-ACP on Enamel White Spot Lesions
Status: UNKNOWN
Conditions: White Spot Lesion of Tooth
Interventions: OTHER: pearl powder|DRUG: CPP-ACP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Aspirin Statins Or Both For The Reduction Of Thrombin Generation In Diabetic People
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Aspirin|DRUG: Atorvastatin|DRUG: Aspirin + Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prognostic Study of Sentinel Lymph Node and Bone Marrow Metastases in Women With Stage I or Stage IIA Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: immunohistochemistry staining method|PROCEDURE: lymphangiography|PROCEDURE: sentinel lymph node biopsy|PROCEDURE: therapeutic conventional surgery|RADIATION: whole breast irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Benefits of Enhanced Recovery After Surgery (ERAS) Protocol in Pelvic Prolapse
Status: COMPLETED
Conditions: Urinary Incontinence|Pelvic Organ Prolapse
Interventions: BEHAVIORAL: ERAS Protocol|BEHAVIORAL: Conventional care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Three Vision Therapy Approaches for Convergence Insufficiency
Status: UNKNOWN
Conditions: Comparison of Three Vision Therapy Approaches for Convergence Insufficiency
Interventions: PROCEDURE: trained to do the pencil push-ups procedure|PROCEDURE: using a major amblyoscope twice weekly with additional home orthoptic therapy|PROCEDURE: using three diopter over-minus lenses and a base out prism
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study to Evaluate the Microbiology and Safety of C16G2 Administered to Adult and Adolescent Dental Subjects
Status: COMPLETED
Conditions: Dental Caries
Interventions: DRUG: C16G2 Gel|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Instrumentation Technique on Endodontic Outcome
Status: COMPLETED
Conditions: Apical Periodontitis
Interventions: OTHER: Root Canal Treatment with hand instruments|OTHER: Root canal treatment with Protaper instruments|OTHER: Root canal treatment with hybrid instrumentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1, Healthy Subject, Safety, Tolerability and Pharmacokinetic Study of mGlu5 NAM HTL0014242
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HTL0014242|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Self-monitoring and Reminder Texts to Increase Physical Activity After Cancer: a Pilot Randomized Controlled Trial
Status: COMPLETED
Conditions: Colon Cancer|Rectum Cancer
Interventions: BEHAVIORAL: Digital Health Physical Activity Intervention Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Retinal Vein Occlusion (RVO) With Open-Label Anecortave Acetate (15mg.)
Status: WITHDRAWN
Conditions: Retinal Vein Occlusion
Interventions: DRUG: Anecortave Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability, and Efficacy Study of VC-01™ Combination Product in Subjects With Type I Diabetes Mellitus
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus
Interventions: COMBINATION_PRODUCT: VC-01™ Combination Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase 1b Study of Demcizumab Plus Pembrolizumab in Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Locally Advanced or Metastatic Solid Tumors
Interventions: DRUG: Demcizumab|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness, Safety and Perceptions With the Use of One LED Blanket Device in the Ambulatory Treatment of Jaundice
Status: COMPLETED
Conditions: Jaundice, Neonatal|Phototherapy
Interventions: DEVICE: Neomedlight Phototherapy Blanket|DEVICE: Ohmeda-Fiber Optic Phototherapy Blanket
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Safety Study of SyB L-1101 in Patients With Recurrent/Relapsed or Refractory Myelodysplastic Syndrome (MDS) - Extension Study
Status: COMPLETED
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: SyB L-1101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Investigate the Effects of Creatine Supplementation on Muscle Energetics and Cognitive Function in Young Healthy Male Athletes and an Ageing Population
Status: COMPLETED
Conditions: Nutritional Status
Interventions: DRUG: Creatine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Trial on Remote Ischemic Conditioning and Hypertension（HOPE）
Status: UNKNOWN
Conditions: Essential Hypertension
Interventions: DEVICE: remote ischemic conditioning|DEVICE: ambulatory blood pressure monitoring|DEVICE: Sham remote ischemic conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Study Evaluating the Efficacy of Noradrenaline in the Prevention of Hypotension Related to Intubation for Cardiac or Thoracic Surgery
Status: COMPLETED
Conditions: Cardiac Disorder|Hypotension
Interventions: DRUG: noradrenaline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Personalized Phage Treatment in Covid-19 Patients With Bacterial Co-Infections Microbials for Pneumonia or Bacteremia/Septicemia
Status: NO_LONGER_AVAILABLE
Conditions: Covid19|Bacteremia|Septicemia|Acinetobacter Baumannii Infection|Pseudomonas Aeruginosa Infection|Staph Aureus Infection
Interventions: OTHER: Phage Therapy
Study Type: EXPANDED_ACCESS
Clinical trial: A Study of Vedolizumab Intravenous (IV) and Adalimumab or Vedolizumab and Ustekinumab in Adults With Crohn's Disease
Status: RECRUITING
Conditions: Crohn's Disease
Interventions: DRUG: Vedolizumab|DRUG: Adalimumab|DRUG: Ustekinumab|DRUG: Ustekinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety,Tolerability and Immunogenicity of Vaccination With Rotateq in Healthy Infants in India (V260-021)
Status: COMPLETED
Conditions: Gastroenteritis|Rotavirus
Interventions: BIOLOGICAL: Rotavirus Vaccine, Live, Oral, Pentavalent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: MicroPulse TLT - UK Study
Status: NOT_YET_RECRUITING
Conditions: Glaucoma|Glaucoma Eye|Glaucoma, Open-Angle|Glaucoma Secondary|Glaucoma, Angle-Closure|Glaucoma, Neovascular|Glaucoma Traumatic|Glaucoma Uveitic
Interventions: DEVICE: Micropulse Transscleral laser therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Long-term Extension Study of JNJ-77242113 in Participants With Moderate-to-Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: JNJ-77242113
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Caring Universities Project: EsteemUp RCT
Status: ENROLLING_BY_INVITATION
Conditions: Self Esteem
Interventions: BEHAVIORAL: EsteemUp|BEHAVIORAL: EsteemUp-G
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Darwish Hysteroscopic Test (Hysteroscopic Bubble Suction and Tubal Peristalsis of Darwish Triad) in Myomatous Uterus
Status: RECRUITING
Conditions: Tubal Patency and Peristalsis During Hysteroscopy
Interventions: DIAGNOSTIC_TEST: Darwish test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dose Escalation and Expansion Study of SAR443216 in Participants With Relapsed/Refractory HER2 Expressing Solid Tumors
Status: TERMINATED
Conditions: Neoplasm Malignant|Breast Cancer|Lung Neoplasm Malignant|Gastric Cancer|Neoplasm
Interventions: DRUG: SAR443216 IV|DRUG: SAR443216 SC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Foley Bulb With Low Dose Pitocin Versus Foley Bulb With a Standard Incremental Infusion Protocol for the Induction of Labor
Status: COMPLETED
Conditions: Induction of Labor
Interventions: DRUG: pitocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effect of Distance Learning Vocational Rehabilitation on Employment Outcomes of Veterans With Psychiatric Illness and Histories of Legal Convictions
Status: COMPLETED
Conditions: Unemployment|Mental Illness|Substance Use Disorder|Legal History
Interventions: BEHAVIORAL: Distant vocational learning|OTHER: Basic vocational services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of the Evaluation of the Adrenal Function After Discontinuation of a Prolonged Therapy With Corticosteroids
Status: TERMINATED
Conditions: Adrenocortical Insufficiency
Interventions: BIOLOGICAL: "long" synacthen stimulation test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Reactivating NK Cells in Treating Refractory Head and Neck Cancer
Status: UNKNOWN
Conditions: Nasopharyngeal Cancer|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Cetuximab + NK cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Toripalimab Combined With Radiotherapy and Chemotherapy in the Treatment of SNMM After Endoscopic Surgery
Status: RECRUITING
Conditions: Malignant Melanoma|Sinonasal Melanoma
Interventions: PROCEDURE: endoscopic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CysLT1-r Expression Following Allergen Exposure in Asthma and Allergic Rhinitis
Status: UNKNOWN
Conditions: Asthma|Allergic Rhinitis
Interventions: PROCEDURE: Allergen challenge|PROCEDURE: Allergen challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Usability of a Robotic Gait Device for Children and Adolescents With Neurological or Neuromuscular Disease in Their Natural Environment
Status: RECRUITING
Conditions: Cerebral Palsy|Acquired Brain Injury|Spinal Muscular Atrophy
Interventions: DEVICE: EXPLORER
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Exercise on Metabolic Parameters, Anthropometric Measurement Values and Quality of Life
Status: RECRUITING
Conditions: Type1diabetes|Metabolic Syndrome|Nursing Caries
Interventions: OTHER: Exercise with augmented reality glasses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Granulocyte Colony Stimulating Factor Versus Human Chorionic Gonadotropin in Females With a History of RIF
Status: UNKNOWN
Conditions: Fertility Disorders
Interventions: DRUG: Granulocyte Colony Stimulated Factor|DRUG: Human Chorionic Gonadotropins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BAY38-9456, 5/10/20mg, vs.Placebo in Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Levitra (Vardenafil, BAY38-9456)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 28-day Repeat Dose and Drug Interaction Study With Orvepitant (GW823296)
Status: COMPLETED
Conditions: Depressive Disorder
Interventions: DRUG: GW823296 tablet|DRUG: GW823296 matching placebo|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Role Of Lactobacillus Reuteri DSM 17938 In The Non-Complicated Diverticular Disease
Status: UNKNOWN
Conditions: Diverticulosis|Diverticulitis
Interventions: DIETARY_SUPPLEMENT: Lactobacillus Reuterii|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relapse of Ankylosing Spondylitis Patients Withdrawal Etanercept After Clinical Remission: a Following-up Study
Status: COMPLETED
Conditions: Spondylitis, Ankylosing|Recurrence
Interventions: DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase III Open-Label, Multi-Center, Long-Term Extension Study of Depakote ER in Subjects Who Either Completed or Prematurely Discontinued Due to Ineffectiveness From Study M02-488.
Status: COMPLETED
Conditions: Migraines
Interventions: DRUG: divalproex sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Dose Radiotherapy Following High Dose Chemotherapy in Intracranial Non-germinomatous Germ Cell Tumor
Status: UNKNOWN
Conditions: Intracranial Non-germinomatous Germ Cell Tumor
Interventions: DRUG: Carboplatin|DRUG: Etoposide|DRUG: Cyclophosphamide|DRUG: Bleomycin|DRUG: Thiotepa|DRUG: Melphalan|RADIATION: Reduced dose radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of QGE031versus Placebo and Omalizumab in Patients Aged 18-75 Years With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: QGE031|DRUG: Omalizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Physical and Virtual Sensory Room in an Inpatient Setting
Status: COMPLETED
Conditions: Anxiety State|Depression|Bipolar Depression
Interventions: DEVICE: Virtual sensory room|OTHER: Sensory room
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation
Status: RECRUITING
Conditions: Cardiac Arrest With Successful Resuscitation|Hypoxia, Brain
Interventions: DEVICE: Feedback-controlled temperature device|OTHER: High MAP|OTHER: Deep sedation|OTHER: Fever control without a device|OTHER: Low MAP|OTHER: Minimal sedation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Confocal Laser Endomicroscopy Based Diet in Functional Dyspepsia
Status: RECRUITING
Conditions: Functional Dyspepsia
Interventions: OTHER: Real diet|OTHER: Sham diet|OTHER: Wheat exclusion diet|OTHER: Soy exclusion diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study To Evaluate The Safety and Efficacy of Hemoglobin Raffimer in Patients Undergoing First Time CABG Surgery
Status: SUSPENDED
Conditions: Cardiovascular Disease
Interventions: DRUG: Hemolink (hemoglobin raffimer IV solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Protective Efficacy of a Spatial Repellent to Reduce Malaria Prevalence in Uganda
Status: RECRUITING
Conditions: Malaria|Mosquito-Borne Disease
Interventions: DEVICE: Mossie-Go containing treated transfluthrin disc|DEVICE: Mossie-Go containing untreated blank disc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Broncho-Vaxom (OM 85 BV) in Children Suffering From Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Broncho-Vaxom|DRUG: Placebo - Cap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Tolerance Evaluation of an Anti-age Food Supplement
Status: COMPLETED
Conditions: Moderate-severe Skin Aging/Photoaging
Interventions: DIETARY_SUPPLEMENT: Pre-Hyaluron 465 Innēov
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Normal Saline Versus Plasmalyte in Initial Resuscitation of Trauma Patients
Status: COMPLETED
Conditions: Wounds and Injuries|Multiple Trauma|Disorder of Fluid Balance
Interventions: OTHER: Plasmalyte A|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Nasal and Oral Airway Use on Gastric Insufflation
Status: COMPLETED
Conditions: Gastric Insufflation|Difficult Mask Ventilation
Interventions: DEVICE: nasal airway|DEVICE: oral airway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pain Relief Results After Anterior Cruciate Ligament (ACL) Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Rupture
Interventions: PROCEDURE: Single-injection femoral nerve block|PROCEDURE: Femoral nerve block 60-hour continuous injection|PROCEDURE: Saline (control) injection into femoral nerve envelope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy Before Surgery in Treating Patients With Hormone Receptor Positive, HER2 Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Estrogen Receptor Positive|HER2/Neu Negative|Invasive Breast Carcinoma|Progesterone Receptor Positive
Interventions: RADIATION: Radiation Therapy|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial to Compare a Regimen of Trimethoprim-sulfamethoxazole Plus Rifampicin With a Regimen of Linezolid in the Treatment of Methicillin-Resistant Staphylococcus Aureus (MRSA) Infection
Status: COMPLETED
Conditions: MRSA Infection
Interventions: DRUG: trimethoprim-sulfamethoxazole (TMP-SMX)|DRUG: Linezolid|DRUG: Rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PATH 2 Purpose: Primary Care and Community-Based Prevention of Mental Disorders in Adolescents
Status: UNKNOWN
Conditions: Depression
Interventions: BEHAVIORAL: CATCH-IT|BEHAVIORAL: TEAMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Defining the Optimal Duration of Treatment for "Low-Risk" Peritoneal Dialysis-Related Peritonitis
Status: WITHDRAWN
Conditions: Peritoneal Dialysis-associated Peritonitis
Interventions: DRUG: Cefazolin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decreased Neuraxial Morphine After Cesarean Delivery
Status: ACTIVE_NOT_RECRUITING
Conditions: Anesthesia
Interventions: DRUG: Morphine Sulfate 150 mcg|DRUG: Morphine Sulfate 50mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First-in-Man Study of the Firesorb BVS (FUTURE-I)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Sirolimus Target Eluting Bioresorbable Vascular Scaffold
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of B001 Injection in the Treatment of Neuromyelitis Optica Spectrum Disorders(NMOSD)
Status: RECRUITING
Conditions: Neuromyelitis Optica Spectrum Disorders
Interventions: DRUG: B001|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma
Status: NOT_YET_RECRUITING
Conditions: Leiomyosarcoma|Liposarcoma|Synovial Sarcoma|Angiosarcoma|Undifferentiated Pleomorphic Sarcoma|Epithelioid Sarcoma|Malignant Peripheral Nerve Sheath Tumors|Fibrosarcoma|Pleomorphic Rhabdomyosarcoma|Endometrial Stromal Sarcoma|Desmoplastic Small Round Cell Tumor
Interventions: BIOLOGICAL: MASCT-I|DRUG: Doxorubicin|DRUG: Ifosfamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Three Techniques for Ultrasound-guided Internal Jugular Cannulation
Status: COMPLETED
Conditions: Ultrasound-guided Internal Jugular Cannulation|Central Venous Access Complications
Interventions: PROCEDURE: Ultrasound-guided Internal jugular venous approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of a Training Program in Improving Coping Skills in People With Arthritis Pain
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: BEHAVIORAL: Coping skills training (CST) for chronic pain|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Postoperative Pain After Vessel Sealing Device Versus Conventional Suturing Methods for Vaginal Hysterectomy and Pelvic Reconstructive Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Pelvic Organ Prolapse
Interventions: DEVICE: LigaSureTM vessel sealing device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers in High Risk Subjects Compared to Arthrotec
Status: TERMINATED
Conditions: Gastric Ulcer
Interventions: DRUG: PN400 (VIMOVO)|DRUG: Diclofenac/Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Ritonavir on the Single-Dose Pharmacokinetics of JNJ-61393215 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-61393215|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Propofol to Reduce the Incidence of Postanesthetic Emergence Agitation in Pediatric Patients Under General Anesthesia
Status: COMPLETED
Conditions: Pediatric ALL
Interventions: DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fluoride in Saliva After Use of Fluoride Toothpastes Followed by Fluoride Mouthrinses
Status: ENROLLING_BY_INVITATION
Conditions: Dental Caries
Interventions: DRUG: Crest Cavity Protection toothpaste|DRUG: Crest Cavity Protection toothpaste followed by Act Mint Fluoride Rinse|DRUG: Colgate PreviDent 5000+ toothpaste|DRUG: Colgate PreviDent 5000+ toothpaste followed by Act Mint Fluoride Rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Salvage Surgery Following Downstaging of Advanced Non-small Cell Lung Cancer by Targeted Therapy (SDANT)
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Osimertinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare Subperiosteal and Loco-Regional Anesthesia in Posterior Mandible Dental Implant Installation
Status: UNKNOWN
Conditions: Surgical Complications From Local Anesthesia|Dental Implant Failed|Anesthesia Complications|Anesthesia Morbidity
Interventions: DEVICE: Dental Implants in Posterior Mandible|DRUG: Subperiosteal 1:100.000 Articaine 4% epinephrine|DRUG: Loco-regional 1:100.000 Articaine 4% epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intervention to Address Psychosocial Needs Among Socially Disadvantaged Older Adults With Cancer
Status: TERMINATED
Conditions: Hematological Disorder
Interventions: BEHAVIORAL: Focus Group Discussions and Semi-structured Interviews|BEHAVIORAL: Training community lay navigators
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Different Up-dosing Schedules With Osiris
Status: TERMINATED
Conditions: Allergic Rhinitis
Interventions: DRUG: OSIRIS|DRUG: OSIRIS other concentration 1|DRUG: OSIRIS other concentration 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Lokomat and Aquatic Exercise for Individuals With Chronic Incomplete Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: DEVICE: Lokomat treadmill training|OTHER: Aquatic exercise therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Raltegravir (MK0518) in HIV-Infected Patients Failing Current Antiretroviral Therapies (0518-019)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: raltegravir potassium|DRUG: Comparator: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized，Controlled and Open-label Study of Buspirone add-on Treatment in Patients With Major Depression Disorder
Status: UNKNOWN
Conditions: Major Depression Disorder
Interventions: DRUG: Buspirone|DRUG: Paroxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microsphere Localization Using PET/MRI or PET/CT in Patients Following Radioembolization
Status: TERMINATED
Conditions: Liver Neoplasms
Interventions: DEVICE: PET/MR|DEVICE: PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Carfilzomib and Lenalidomide With Dexamethasone Combination in Newly Diagnosed, Previously Untreated Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: carfilzomib, lenalidomide plus dexamethasone|DRUG: carfilzomib, lenalidomide plus dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluating the Adherence Improving Self-Management Strategy Intervention in Chronic Heart Failure Patients
Status: COMPLETED
Conditions: Chronic Heart Failure|Heart Decompensation|Myocardial Failure|Preserved Ejection Fraction|Reduced Ejection Fraction
Interventions: BEHAVIORAL: Adherence Improving self-Management Strategy|OTHER: Treatment-as-usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Capsule Endoscopy vs Standard of Care for Obscure Intestinal Bleeding
Status: COMPLETED
Conditions: Iron Deficiency Anemia
Interventions: DEVICE: Diagnostic Test - Given Imaging Pillcam|OTHER: Diagnostics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ultrasound-guided Percutaneous Dilatation Tracheostomy: Does it Have a Role in Obese Patients?
Status: UNKNOWN
Conditions: Tracheostomy Techniques
Interventions: PROCEDURE: tracheostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effect of Antibiotic Choice On ReNal Outcomes (ACORN)
Status: COMPLETED
Conditions: Sepsis|AKI|Neurotoxicity
Interventions: DRUG: anti-pseudomonal cephalosporin|DRUG: anti-pseudomonal penicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Amplification of Positivity for Alcohol Use
Status: RECRUITING
Conditions: Alcohol Use Disorder|Anxiety|Depression
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Amplification of Positivity Therapy|BEHAVIORAL: Surveys and Interviews
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Tadalafil (LY450190) in Participants With Lower Urinary Tract Symptoms (LUTS) Suggestive of Benign Prostatic Hyperplasia LUTS (BPH-LUTS).
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: Tadalafil|DRUG: Placebo|DRUG: Alpha1 Blocker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Laser Treatment of Reticular Leg Veins vs. Sclerotherapy
Status: RECRUITING
Conditions: Reticular Leg Veins
Interventions: PROCEDURE: Laser ablation|PROCEDURE: Laser with Sclerotherapy|PROCEDURE: Sclerotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab for the Treatment of Locally Advanced and/or Recurrent Orbital or Periocular Cutaneous Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck|Recurrent Cutaneous Squamous Cell Carcinoma of the Head and Neck|Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8
Interventions: PROCEDURE: Computed Tomography|OTHER: Digital Photography|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pediatric Pharmacokinetic (PK) Study of EXE844 Otic Suspension in Otitis Media at the Time of Tympanostomy Tube Insertion (OMTT)
Status: COMPLETED
Conditions: Otitis Media With Effusion in Children|Otitis Media Recurrent
Interventions: DRUG: EXE844 Sterile Otic Suspension, 0.3%|PROCEDURE: Tympanostomy Tube Insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER