pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With a Novel Form of Anaplerosis
Status: COMPLETED
Conditions: Ataxia Telangiectasia
Interventions: DIETARY_SUPPLEMENT: Triheptanoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Pharmacokinetic Study of Omaveloxolone in Subjects With Hepatic Impairment and Normal Hepatic Function
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: Omaveloxolone 50 mg capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Treatment of Triple Negative Breast Cancer Patients With Docetaxel and Carboplatin to Assess Anti-tumor Activity
Status: TERMINATED
Conditions: Triple Negative Breast Neoplasms
Interventions: DRUG: Docetaxel|DRUG: Carboplatin|PROCEDURE: FDG-PET/MR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Simplification by Darunavir/Ritonavir 800/100 mg Once a Day Versus a Triple Combination Therapy With Darunavir/Ritonavir
Status: COMPLETED
Conditions: HIV Infections|AIDS Virus|Human Immunodeficiency Virus|Acquired Immunodeficiency Syndrome Virus
Interventions: DRUG: darunavir (DRV, TMC114)|DRUG: darunavir (DRV, TMC114)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Linagliptin in Type-2-diabetes Mellitus Patients With Moderate to Severe Renal Impairment
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Glimepiride|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Linagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury
Status: COMPLETED
Conditions: Critically Ill|Acute Kidney Injury
Interventions: DRUG: Calcifediol|DRUG: Calcitriol|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Carfilzomib/SAHA Combined With High-Dose Gemcitabine/Busulfan/Melphalan With Autologous Stem Cell Transplant in Myeloma
Status: WITHDRAWN
Conditions: Myeloma
Interventions: DRUG: Carfilzomib|DRUG: SAHA|DRUG: Gemcitabine|DRUG: Busulfan|DRUG: Melphalan|PROCEDURE: Stem Cell Transplant (SCT)|DRUG: Palifermin|DRUG: Dexamethasone|DRUG: Caphosol|DRUG: Glutamine|DRUG: Pyridoxine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Self- and Family Management of Diabetic Foot Ulcers Programs on Health Outcomes
Status: COMPLETED
Conditions: Diabete Mellitus|Diabetic Foot
Interventions: BEHAVIORAL: Self-and family management of diabetic foot ulcers programs|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness and Safety of Early Intramuscular Botulinum Toxin Injections to Prevent Shoulder Deformity in Babies With Obstetrical Brachial Plexus Palsy
Status: RECRUITING
Conditions: Obstetrical Brachial Plexus Palsy
Interventions: DRUG: Botulinum toxin type A injection|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Olaparib and Pembrolizumab in Advanced Melanoma With Homologous Recombination (HR) Mutation
Status: RECRUITING
Conditions: Metastatic Melanoma
Interventions: DRUG: Olaparib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Community-Acquired Pneumonia Diagnosis Using Lung Ultrasound in Emergency Room Adults
Status: UNKNOWN
Conditions: Community-acquired Pneumonia
Interventions: DIAGNOSTIC_TEST: Lung Ultrasound (LUS)|DIAGNOSTIC_TEST: Chest radiography (CR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of a Supervised Exercise Program and a Home Exercise Program in Patients With Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis|Home Exercise|Aerobic Exercise
Interventions: OTHER: supervised Exercise training|OTHER: home exercise trainig
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Treatment and Prevalence of P. Acnes
Status: COMPLETED
Conditions: Surgical Site Infection
Interventions: DRUG: Clindamycin 1% Gel|DRUG: Benzoyl peroxide 5% gel|DRUG: BenzaClin 5%-1% Topical Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Innovative Chinese Herbal Formula for Macular Edema
Status: RECRUITING
Conditions: Macula Edema
Interventions: DRUG: modified Shenling Baizhu San|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of [6R] 5,10-methylenetetrahydrofolate (Arfolitixorin) as Rescue Therapy for Osteosarcoma Patients Treated With HDMTX.
Status: COMPLETED
Conditions: Osteosarcoma
Interventions: DRUG: Calcium Folinate|DRUG: [6R] 5,10-methylenetetrahydrofolate (arfolitixorin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sodium Glucose co Transporter 2 Inhibitor ( SGLT2) on Proteinuria in Diabetic Patients
Status: UNKNOWN
Conditions: Diabetic Nephropathies
Interventions: DRUG: SGLT2 inhibitor|DRUG: ACE inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metal-ions in Patients With the PEEK HD Coupling Mechanism of the Knee
Status: NOT_YET_RECRUITING
Conditions: Mutars|Modular Universal Tumor And Revision System|Metal-ions|Tumor Prosthesis|Megaprosthesis|PEEK-HD Coupling Mechanism|Knee Endoprosthesis
Interventions: OTHER: Blood sample analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 3D Guided Internal Jugular Vein Catheterization
Status: COMPLETED
Conditions: Catheter Related Complication|Ultrasound; Complications
Interventions: DEVICE: 3DUS biplanar catheterization|DEVICE: 2D US catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Post Operative Pain After Laparoscopic Hysterectomy Using Airseal® Versus Standard Insufflation System
Status: COMPLETED
Conditions: Laparoscopic Hysterectomy
Interventions: DEVICE: Airseal®|DEVICE: Standard insufflator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shuxuening Injection in the Treatment With Intravenous Thrombolysis in Patients With Ischemic Stroke (SHINY)
Status: RECRUITING
Conditions: Ischemic Stroke, Acute
Interventions: DRUG: Shuxuening Injection|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Accelerated Intermittent Theta-Burst Stimulation (aiTBS) in Treatment-Resistant Depression of Bipolar II Disorder
Status: RECRUITING
Conditions: Bipolar II Disorder, Most Recent Episode Major Depressive|Current Depressive Episode|Treatment Resistant Depression
Interventions: DEVICE: Active Comparator: Active aiTBS|DEVICE: Sham Comparator: Sham aiTBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treatment With Human Umbilical Cord-derived Mesenchymal Stem Cells for Severe Corona Virus Disease 2019 (COVID-19)
Status: COMPLETED
Conditions: Corona Virus Disease 2019(COVID-19)
Interventions: BIOLOGICAL: UC-MSCs|BIOLOGICAL: Saline containing 1% Human serum albumin（solution without UC-MSCs）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pembrolizumab (MK-3475) in Combination With Standard of Care Treatments in Participants With Multiple Myeloma (MK-3475-023/KEYNOTE-023)
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: Carfilzomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketone Monoester and Blood Pressure
Status: NOT_YET_RECRUITING
Conditions: Blood Pressure
Interventions: DIETARY_SUPPLEMENT: BHB supplement|OTHER: Placebo solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Oral Effects of Heated Tobacco Products
Status: COMPLETED
Conditions: Nicotine Dependence, Cigarettes
Interventions: DEVICE: IQOS 3.0 DOU with bland taste unit (Heated Tobacco Product)|DEVICE: IQOS 3.0 DUO with menthol taste unit (Heated Tobacco Product)|DEVICE: Marlboro Gold (Conventional cigarette)|DEVICE: IQOS 3.0 DUO turned off with a bland taste unit
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Chemotherapy, Total-Body Irradiation, Rituximab, and Donor Stem Cell Transplant in Treating Patients With B-Cell Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: anti-thymocyte globulin|BIOLOGICAL: filgrastim|BIOLOGICAL: graft-versus-tumor induction therapy|BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: fludarabine phosphate|DRUG: mycophenolate mofetil|PROCEDURE: nonmyeloablative allogeneic hematopoietic stem cell transplantation|RADIATION: total-body irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Navigated Endoscopy for the Placement of High Dose Rate Brachytherapy Applicators in the Esophagus and Lung
Status: TERMINATED
Conditions: Esophagus Cancer|Lung Cancer
Interventions: DEVICE: Navigated Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Evaluation of a "Flash-free" Adhesive Resin for Orthodontic Bracket Bonding
Status: COMPLETED
Conditions: Malocclusion
Interventions: DEVICE: APC Flash-Free Adhesive Coated Appliance System|DEVICE: APC II Adhesive Coated Appliance System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Recombinant Factor XIII Administration in Healthy Volunteers
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Congenital FXIII Deficiency|Healthy
Interventions: DRUG: catridecacog|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Three Laryngoscopes in Difficult Laryngoscopy
Status: COMPLETED
Conditions: Intubation; Difficult
Interventions: DEVICE: Intubation- Macintosh laryngoscope|DEVICE: Intubation- MacCoy laryngoscope|DEVICE: Intubation- Airtraq laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Explore Plasma Levels of CONCERTA, Ritalin-SR and Novo-Methylphenidate ER-C in Healthy Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Ritalin-SR|DRUG: Concerta|DRUG: Novo-Methylphenidate ER-C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Event-Related Potential (ERP) Biomarkers in Subjects With Schizophrenia and Healthy Volunteer Subjects
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DEVICE: Event-Related Potentials (ERP) and Electroencephalogram (EEG) testing with the COGNISION® System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Symptomatic Severe Aortic Stenosis in High Risk and Very High Risk Subjects Who Need Aortic Valve Replacement
Status: COMPLETED
Conditions: Severe Aortic Stenosis
Interventions: DEVICE: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI)|DEVICE: Surgical Aortic Valve Replacement (SAVR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pioglitazone in Alzheimer Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Gilteritinib (ASP2215) Combined With Chemotherapy in Children, Adolescents and Young Adults With FMS-like Tyrosine Kinase 3 (FLT3)/Internal Tandem Duplication (ITD) Positive Relapsed or Refractory Acute Myeloid Leukemia (AML)
Status: RECRUITING
Conditions: Acute Myeloid Leukemia (AML)|Acute Myeloid Leukemia With FMS-like Tyrosine Kinase 3 (FLT3) Mutation / Internal Tandem Duplication (ITD)
Interventions: DRUG: gilteritinib|DRUG: fludarabine|DRUG: cytarabine|DRUG: granulocyte colony-stimulating factor (G-CSF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using VR to Assess the Efficacy of a Motivational Interviewing Intervention to Increase Bystander Behaviors
Status: COMPLETED
Conditions: Sexual Assault
Interventions: BEHAVIORAL: Motivate-The-Bystander (MTB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Segmental and Pursed Lip Breathing Exercises on Upper Cross Syndrome
Status: COMPLETED
Conditions: UPPER CROSS SYNDROME
Interventions: OTHER: Manual PT/ Conventional PT Treatment + Segmental and Pursed Lip Breathing Exercise|OTHER: Manual PT/Conventional PT Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Copper Intrauterine Device (IUD) Insertion at Cesarean Delivery
Status: COMPLETED
Conditions: Intrauterine Device Expulsion
Interventions: DEVICE: Copper IUD placement at time Cesarean Delivery (Copper T 380A)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparative Bioequivalence Study of Wockhardt's Insulin Analogue Mixture Listro Mix 75/25® and Humalog Mix75/25 ® in Healthy Subjects
Status: WITHDRAWN
Conditions: Bioequivalence in Healthy Subjects
Interventions: BIOLOGICAL: Insulin Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Yttrium Y 90 Ibritumomab Tiuxetan and Rituximab in Treating Patients With Previously Untreated Marginal Zone Lymphoma
Status: COMPLETED
Conditions: Marginal Zone Lymphoma
Interventions: DRUG: Rituximab|DRUG: Ibritumomab Tiuxetan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measuring the Impact of MANNA s Medically Tailored Meal Program in Patients With a Non-terminal Cancer Diagnosis
Status: COMPLETED
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Interview|OTHER: Survey Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ecopipam Treatment of Self-Injurious Behavior in Subjects With Lesch-Nyhan Disease
Status: TERMINATED
Conditions: Lesch-Nyhan Disease|Self-injurious Behavior
Interventions: DRUG: Ecopipam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy With Whole Body Hyperthermia to Treat Resistant Breast, Endometrial, Cervical and Ovarian Cancers
Status: UNKNOWN
Conditions: Breast Neoplasms|Endometrial Neoplasms|Cervix Neoplasms|Ovarian Neoplasms
Interventions: OTHER: thermochemotherapy (with 5-fluorouracil/interferon-a/liposomal doxorubicin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to a TNF-Blocker.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: rituximab [MabThera/Rituxan]|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Dragon Fruit Consumption on Vascular Function.
Status: COMPLETED
Conditions: Healthy Men and Women
Interventions: DIETARY_SUPPLEMENT: Dragon fruit juice drink|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Compare the Efficacy and Safety of Administration of the Fix Dose Combination of Linagliptin Plus Metformin in Drug naïve Type 2 Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: linagliptin2.5mg/metformin1000mg|DRUG: linagliptin2.5mg/metformin1000mg|DRUG: linagliptin 5mg|DRUG: Metformin 500mg|DRUG: linagliptin2.5mg/metformin500mg|DRUG: linagliptin2.5mg/metformin500mg|DRUG: linagliptin 5mg|DRUG: Metformin 1000mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Integrated Care for Inflammatory Bowel Disease Patients in the Netherlands With the Novel Telemedicine Tool myIBDcoach: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Inflammatory Bowel Disease
Interventions: OTHER: myIBDcoach|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: DEDICATE: aDvancing carE Management aDoption In Community heAlTh cEnters
Status: NOT_YET_RECRUITING
Conditions: Social Determinants of Health|Primary Care|Diabetes Mellitus, Type 2|Hypertension
Interventions: OTHER: Implementation Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Elimination of Odor and Treatment of Malodorous Recalcitrant Wounds by Using Supraz and PRP-FG Versus Standard of Care
Status: RECRUITING
Conditions: Wounds and Injuries
Interventions: DRUG: Platelet-Rich Plasma-Fibrin Glue|DRUG: Repairing Gel|DRUG: Repairing Gel and Platelet-Rich Plasma-Fibrin Glue|OTHER: Classical wound irrigation (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation the Treatment of Nonunion of Long Bone Fracture of Lower Extremities (Femur and Tibia) Using Mononuclear Stem Cells From the Iliac Wing Within a 3-D Tissue Engineered Scaffold
Status: UNKNOWN
Conditions: Nonunion of Fracture
Interventions: GENETIC: surgical treatment of non union with mesenchymal stem cells with BMP2 within a 3-D tissue engineered scaffold
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab, Combination Chemotherapy, and Radiation Therapy in Treating Patients Undergoing Surgery For Locally Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: fluorouracil|DRUG: gemcitabine hydrochloride|DRUG: oxaliplatin|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|PROCEDURE: conventional surgery|PROCEDURE: endoscopic biopsy|PROCEDURE: laparoscopy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Impracor (Ketoprofen 10% Cream) Compared With Placebo in the Treatment of Acute Pain (Flare) Associated With Osteoarthritis of the Knee
Status: WITHDRAWN
Conditions: Acute Pain (Flare) Associated With Osteoarthritis (OA) of the Knee
Interventions: DRUG: Ketoprofen 10% Cream|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Advanced Decision Support Tool, Opt-IVF for Clinical Ivf Practice
Status: COMPLETED
Conditions: Infertility
Interventions: OTHER: traditional drug treatment|OTHER: Opt-IVF predicted dosage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multimodal Analgesic Technique for Control of Post-laproscopy Abdominal Pain
Status: COMPLETED
Conditions: Decrease Post Laproscopy Shoulder and Abdominal Pain
Interventions: DRUG: Intraperitoneal lidocaine|PROCEDURE: Pulmonary Recruitment|COMBINATION_PRODUCT: Combined intraperitoneal lidocaine and pulmonary recruitment maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Telehealth Program to Prevent Cancer and Chemotherapy-related Cognitive Impairment.
Status: ENROLLING_BY_INVITATION
Conditions: Breast Neoplasms
Interventions: OTHER: e-OTCAT program|OTHER: Educational handbook and standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Adalimumab in Adult Chinese Rheumatoid Arthritis Subjects Treated With Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: Adalimumab 80 mg|BIOLOGICAL: Adalimumab 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CD-NP (Cenderitide) Therapy for the Preservation of Left Ventricular Function
Status: COMPLETED
Conditions: ST Elevation (STEMI) Myocardial Infarction of Anterior Wall
Interventions: DRUG: CD-NP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Focal Vibration and Blood Flow Restriction Within a Multicomponent Exercise Programme.
Status: UNKNOWN
Conditions: Sarcopenia|Occlusion|Vibration; Exposure|Old Age; Atrophy|Exercise Addiction
Interventions: OTHER: Focal Vibration|OTHER: Blood Flow Restriction|OTHER: Traditional Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Direct Biomarkers of Aspirin Action to Develop a Precision Chemoprevention Therapy of Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: acetylsalicylic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Copenhagen Obesity Risk Assessment Study
Status: COMPLETED
Conditions: Metabolic Syndrome|Abdominal Obesity|Heart Disease|Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Trans fat (soy bean oil)|DIETARY_SUPPLEMENT: Control fat (sunflower oil)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase I Study of Osilodrostat (LCI699) in Healthy Volunteers and Subjects With Impaired Renal Function
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: osilodrostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label, One-arm, Study to Evaluate the Hemodynamic Changes and Safety of Nesiritide for Acute Decompensated Heart Failure
Status: COMPLETED
Conditions: Heart Decompensation|Congestive Heart Failure
Interventions: DRUG: Nesiritide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Device Study in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: On-Body Delivery System (OBDS)/Multiple Bolus Injector|DEVICE: Single Auto Injector|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Thyroid Hormone Dose Adjustment in Pregnancy
Status: COMPLETED
Conditions: Pregnancy|Hypothyroidism
Interventions: DRUG: Anticipatory dose increase of levothyroxine|DRUG: levothyroxine|DRUG: levothyroxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FR901228 in Treating Patients With Refractory or Progressive Small Cell Lung Cancer or Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Extensive Stage Small Cell Lung Cancer|Stage IIIA Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer|Recurrent Small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer|Recurrent Non-small Cell Lung Cancer
Interventions: DRUG: FR901228
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Pilot CAR-T Cells Therapy for Children/Young Adults With CD19+ R/R Leukemia/Lymphoma
Status: RECRUITING
Conditions: B-cell Acute Lymphoblastic Leukemia|Lymphoblastic B-Cell Lymphoma
Interventions: BIOLOGICAL: CD19 CAR-T-cells|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cemented vs Cementless in Bilateral TKA
Status: UNKNOWN
Conditions: Osteoarthritis|Total Knee Arthroplasty
Interventions: DEVICE: Triathlon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Disease Progression and Modification Following Treatment With Paliperidone Palmitate Long-Acting Injection or Oral Antipsychotics in Participant's With Recent-onset Schizophrenia or Schizophreniform
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders
Interventions: DRUG: Aripiprazole|DRUG: Haloperidol|DRUG: Olanzapine|DRUG: Oral Paliperidone ER|DRUG: Perphenazine|DRUG: Quetiapine|DRUG: Oral Risperidone|DRUG: Paliperidone Palmitate Injection (PP1M)|DRUG: Paliperidone Palmitate Injection (PP3M)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of the Effect of Etanercept in Hemodialysis Patients
Status: TERMINATED
Conditions: End Stage Renal Disease
Interventions: DRUG: Etanercept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: L-arginine and Asymmetric Dimethylarginine (ADMA) and Lifestyle Protocols
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Obesity|Arginine|Asymmetric Dimethylarginine
Interventions: BEHAVIORAL: Acute dietary protocols and lifestyle modification
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Investigation of the Effects of Diet on the Measurement of Plasma Chromogranin in NET Patients
Status: COMPLETED
Conditions: Neuroendocrine Tumors
Interventions: OTHER: ongoing fasted state, intake of caffeine containing beverages or 5-item English breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Hyperpolarized Carbon-13 (13C) Pyruvate Imaging in Patients With Glioblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma Multiforme (GBM)
Interventions: DRUG: Hyperpolarized 13C Pyruvate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Anti-RSV Study in Chinese Patients (ASCENT)
Status: UNKNOWN
Conditions: Respiratory Syncytial Virus Infections
Interventions: DRUG: AK0529|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Effects of PEEP in ARDS
Status: UNKNOWN
Conditions: Acute Respiratory Distress Syndrome|Mechanical Ventilation|ARDS, Human
Interventions: PROCEDURE: Physiological assesment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A I in the Prediction of Clinical Performance, Marginal Fit and Fracture Resistance of Vertical Versus Horizontal Margin Designs Fabricated With 2 Ceramic Materials
Status: RECRUITING
Conditions: Artificial Intelligence
Interventions: OTHER: change in restoration material and margin design.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Continuous Epidural Fentanyl- Low Dose Bupivacaine Infusion Analgesia for Precious Single Kidney Patient.
Status: COMPLETED
Conditions: Postoperative Analgesia
Interventions: PROCEDURE: Group f : Epidural catheter insertion|DRUG: Group F: Continous epidural infusion of bupivacaine plus fentanyl|DRUG: Group LF :Continous epidural infusion of decreasing doses of fentanyl plus pubivacaine|PROCEDURE: Group L f : Epidural catheter insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Compare the Efficacy, Safety and Tolerability of FF/UMEC/VI With FF/VI in 12-17-year-olds With Asthma
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: FF/UMEC/VI|DEVICE: ELLIPTA|DRUG: FF/VI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of TaiChi on Ischemic Burden of Patients With Coronary Heart Disease Complicated With Renal Insufficiency
Status: NOT_YET_RECRUITING
Conditions: Coronary Heart Disease (CHD)|Renal Insufficiency
Interventions: BEHAVIORAL: Tai Chi Intervention Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integration of Health Information Technology and Promotion of Personhood in Family-Centered Dementia Care
Status: NOT_YET_RECRUITING
Conditions: Neurocognitive Disorders|Alzheimer Disease|Caregiver
Interventions: OTHER: CareHeroes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial for the Evaluation of the Effect of Systemic Low-dose Interleukin-2 (IL-2) on the Immunogenicity of a Vaccine Comprising Synthetic Melanoma Peptides Administered With Granulocyte-macrophage Colony-stimulating Factor (GM-CSF)-In-Adjuvant, in Patients With High Risk Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: low-dose IL-2|BIOLOGICAL: melanoma vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quinoa Effects on Glycemic Index and Satiety
Status: COMPLETED
Conditions: Overweight
Interventions: DIETARY_SUPPLEMENT: Quinoa variety 1|DIETARY_SUPPLEMENT: Quinoa variety 2|DIETARY_SUPPLEMENT: Quinoa variety 3|DIETARY_SUPPLEMENT: Quinoa variety 4|DIETARY_SUPPLEMENT: Anhydrous Glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Adjuvant Therapies for Patients With HCC and MVI
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: TACE|DRUG: Sorafenib|DRUG: TACE plus sorafenib|OTHER: empty control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Exposure Therapy for Gambling Disorder
Status: NOT_YET_RECRUITING
Conditions: Gambling Disorder
Interventions: OTHER: cognitive-behavioral therapy for gambling disorder|OTHER: imaginal exposure therapy focus on gambling cues|OTHER: virtual reality exposure therapy focus on gambling cues
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: TGRX-678 Chinese Phase II in Chronic Myelogenous Leukemia (CML) Patients
Status: NOT_YET_RECRUITING
Conditions: Chronic Myeloid Leukemia|Accelerated Phase CML
Interventions: DRUG: TGRX-678
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dapagliflozin Effect on FunctiOnal Mitral Regurgitation and Myocardial Fibrosis (DEFORM)
Status: RECRUITING
Conditions: Functional Mitral Regurgitation
Interventions: DRUG: dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Patients With Mantle Cell Lymphoma
Status: WITHDRAWN
Conditions: Contiguous Stage II Mantle Cell Lymphoma|Noncontiguous Stage II Mantle Cell Lymphoma|Stage III Mantle Cell Lymphoma|Stage IV Mantle Cell Lymphoma|Recurrent Mantle Cell Lymphoma
Interventions: DRUG: antineoplaston A10|DRUG: antineoplaston AS2-1|PROCEDURE: alternative product therapy|PROCEDURE: biological therapy|PROCEDURE: biologically based therapies|PROCEDURE: cancer prevention intervention|PROCEDURE: complementary and alternative therapy|PROCEDURE: differentiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Comparison Study Between Protopic (Tacrolimus) Ointment and Elidel (Pimecrolimus) Cream in Treating Subjects With Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: tacrolimus ointment|DRUG: pimecrolimus cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Virtual Reality on Postoperative Pain and Anxiety in Cardiac Surgery.
Status: RECRUITING
Conditions: Post Operative Pain|Post Operative Anxiety|Heart Surgery|Coronary Artery Bypass Grafting|Virtual Reality
Interventions: DEVICE: Virtual Reality distraction therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Assess the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Efficacy of AZD2014
Status: COMPLETED
Conditions: Advanced Solid Malignancies
Interventions: DRUG: AZD2014
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Using a Telemedicine Medication Delivery Unit for Older Adults
Status: WITHDRAWN
Conditions: Medication Adherence|Medication Nonadherence|Adverse Reaction to Drug
Interventions: DEVICE: Computerized medication delivery unit (Electronic Medication Management Assistant (EMMA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety Clinical Trial of Intranasal AST-726 for the Prevention of Migraine
Status: UNKNOWN
Conditions: Migraine|Migraine Headache|Migraine Disorders|Migraine With Aura|Migraine Without Aura
Interventions: DRUG: AST-726 Low dose|DRUG: AST-726 High dose|DRUG: AST-726 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dance/Movement Therapy for Bone Mineral Density in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: dance/movement therapy|BEHAVIORAL: treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Health Management Model Construction and Effect Evaluation of Hypertension Patients Based on Disease-related Health Literacy
Status: UNKNOWN
Conditions: Health Literacy|Hypertension
Interventions: BEHAVIORAL: Health education tools combined with health literacy intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dabrafenib With or Without Trametinib in Treating Patients With Recurrent Thyroid Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Follicular Thyroid Cancer|Insular Thyroid Cancer|Papillary Thyroid Cancer|Recurrent Thyroid Cancer
Interventions: DRUG: dabrafenib|DRUG: trametinib|OTHER: Correlative Studies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized,Multicentric Study to Treat Prolapse After Hysterectomy With Amreich Procedure or Total Prolift Procedure
Status: UNKNOWN
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: Vaginal fixation Amreich-Richter|PROCEDURE: Prolift total
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Specific Antimicrobials and MIC Values on the Outcome of Bloodstream Infections Due to ESBL- or Carbapenemase-producing Enterobacterales in Solid Organ Transplantation: an Observational Multinational Study.
Status: COMPLETED
Conditions: Clinically Significant Bacteremia|Organ Transplantation|Infection|Bacteremia|Bacterial Infections|Sepsis|Systemic Inflammatory Response Syndrome|Pathologic Processes|Inflammation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Lymphoma|Neuroblastoma|Retinoblastoma|Sarcoma|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: becatecarin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Transfemoral Amputees When Transitioning From a Mechanical to a Microprocessor Prosthetic Knee
Status: COMPLETED
Conditions: Amputation of Lower Limb Above Knee
Interventions: DEVICE: Own mechanical knee|DEVICE: RheoKnee microprocessor prosthetic knee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Pablizumab Combined With Apatinib and Chemotherapy in Resectable Non-small Cell Lung Cancer： A Prospective, Single Arm, Single Center Phase II Clinical Study of Neoadjuvant Therapy
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: pablizumab combined with apatinib and neoadjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Changing Intestinal Transit Time on Gut Microbial Composition and Metabolism
Status: RECRUITING
Conditions: Diet, Healthy|Metabolic Disease
Interventions: DRUG: Diet + laxative|OTHER: Diet only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Retrospective Study of Implants With Peri-implantitis Surgically Treated Using Enamel Matrix Derivative (EMD)
Status: COMPLETED
Conditions: Determination of Beneficial Effect of Using Enamel Matrix Derivative During Implant Treatment
Interventions: PROCEDURE: peri-implantitis surgery with enamel matrix derivative
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chronic Obstructive Pulmonary Diseases and Proprioceptive Neuromuscular Facilitation
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DIAGNOSTIC_TEST: MIP/MEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection Fraction (LVEF)
Status: COMPLETED
Conditions: Heart Failure|Low T3 Syndrome
Interventions: DRUG: Liothyronine|DRUG: Liothyronine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Fatty Acid Supplementation to Prevent Preterm Birth in High Risk Pregnancies
Status: COMPLETED
Conditions: Preterm Birth
Interventions: DRUG: 17 alpha-Hydroxyprogesterone Caproate and Omega-3 supplement|DRUG: 17 alpha-hydroxy progesterone caproate and Placebo supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Role of Chromoendoscopy in the Early Detection of Esophageal Cancer in Patients With Prior Head and Neck Cancers
Status: COMPLETED
Conditions: Esophageal Squamous Cell Carcinoma|Squamous Cell Carcinoma of the Head and Neck
Interventions: PROCEDURE: NBI endoscopy|PROCEDURE: Lugol chromoendoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Development and Health of Rural Chinese Children Fed Meat as a Daily Complementary Food From 6-18 Mos of Age
Status: COMPLETED
Conditions: Nutritional Deficiencies
Interventions: OTHER: Meat|OTHER: Cereal|OTHER: fortified rice cereal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of 5 Day Embryo Transfer With 2-3 Day Transfer in Patients With Previous In Vitro Fertilization Failure
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: Day 5 embryo transfer group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ad-RTS-hIL-12 With Veledimex in Subjects With Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: BIOLOGICAL: Ad-RTS-hIL-12|DRUG: Veledimex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-points and Full-thickness Biopsy in the Diagnosis of cCR After Neoadjuvant Therapy for Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer|Neoadjuvant Therapy|Complete Remission|Metastasis
Interventions: PROCEDURE: multi-points and full-thickness Biopsy|DIAGNOSTIC_TEST: traditional cCR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn's Disease
Interventions: DRUG: Placebo for Risankizumab SC|DRUG: Risankizumab IV|DRUG: Placebo for Risankizumab IV|DRUG: Risankizumab SC|DRUG: Risankizumab On-Body Injector (OBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Evaluation of Efficacy and Safety of AR882 in Gout Patients
Status: RECRUITING
Conditions: Gout|Arthritis, Gouty|Hyperuricemia|Gout Chronic
Interventions: DRUG: AR882 50 mg|DRUG: AR882 75 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Harnessing Network Science to Personalize Scalable Interventions for Adolescent Depression (TRACK to TREAT Phase 2)
Status: UNKNOWN
Conditions: Depression
Interventions: BEHAVIORAL: Supportive Therapy SSI|BEHAVIORAL: Behavioral Activation SSI|BEHAVIORAL: Growth Mindset SSI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT