pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pharmacometabolomics of Andrographis Paniculata And Metformin In Healthy Volunteers Under Fasting Condition
Status: UNKNOWN
Conditions: Pharmacokinetics|Molecular Mechanisms of Pharmacological Action
Interventions: DRUG: Brand name: Andrographis paniculata (Shine Hempedu Bumi) 1000mg capsules|DRUG: Brand name: Andrographis paniculata (Shine Hempedu Bumi) 2000mg|DRUG: Metformin (Glucophage) 1000mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Primary Subtalar Arthrodesis Versus Late Subtalar Arthrodesis in Sanders Type IV Calcaneal Fractures
Status: COMPLETED
Conditions: Calcaneus Fracture
Interventions: PROCEDURE: open reduction and internal fixation plus primary subtalar arthrodesis|PROCEDURE: conservative management then calcaneoplasty and subtalar arthrodesis.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a School-based Programme Aimed at Promoting Well-being in Adolescents
Status: COMPLETED
Conditions: Adolescent Well-Being|Resilience, Psychological
Interventions: BEHAVIORAL: A Lust for Life|BEHAVIORAL: Waiting list control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study for Participants With Major Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: LY2216684|DRUG: Placebo|DRUG: Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Atazanavir and Ritonavir (ATV/RTV) and an Oral Contraceptive in Healthy Females
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Ortho Tri-Cyclen (ethinyl estradiol + norgestimate)|DRUG: Ortho Tri-Cyclen LO (ethinyl estradiol + norgestimate) + Atazanavir/Ritonavir for 14 days then Ortho Tri-Cyclen for 7 days
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: InterTAN: Integrated Dual Screw Design Improve Biomechanics/Function Following Fixation Surgery
Status: NOT_YET_RECRUITING
Conditions: Fracture of Hip
Interventions: DEVICE: Synthes TFNA|DEVICE: Trigen InterTAN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Assessing The Feasibility Of Outpatient Tubeless Percutaneous Nephrolithotomy (PCNL)
Status: COMPLETED
Conditions: Renal Calculi
Interventions: PROCEDURE: Outpatient Recovery|PROCEDURE: In hospital recovery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Glycemic Control by Flash Monitoring of Glucose (MFG) in Malnourished Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Diabetes Type 2|Malnutrition
Interventions: OTHER: Fortimel energy|OTHER: Nutrision Advanced Diason Energy HP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of Self Management Program on Changes in Physical Activity Level of Knee Osteoarthritis Patients in Spa Therapy
Status: COMPLETED
Conditions: Knee Osteoarthritis|Physical Activity|Education|Self-management|Exercise
Interventions: OTHER: 5 educational workshop|OTHER: written information booklet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Yttrium Y 90 Glass Microspheres in Treating Patients With Unresectable Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Stage III Hepatocellular Carcinoma AJCC v8|Stage IIIA Hepatocellular Carcinoma AJCC v8|Stage IIIB Hepatocellular Carcinoma AJCC v8|Stage IV Hepatocellular Carcinoma AJCC v8|Stage IVA Hepatocellular Carcinoma AJCC v8|Stage IVB Hepatocellular Carcinoma AJCC v8|Unresectable Hepatocellular Carcinoma
Interventions: RADIATION: Yttrium Y 90 Glass Microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thiamine Supplementation in Heart Failure Patients Receiving Full Medical Therapy
Status: COMPLETED
Conditions: Chronic Heart Failure
Interventions: DRUG: Thiamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Automated Electronic Alert for Acute Kidney Injury on the Outcomes of Hospitalized Patients
Status: COMPLETED
Conditions: Acute Kidney Injury|Outcomes|Early Diagnosis
Interventions: DEVICE: AKI alert|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Azilect + Antidepressant Chart Review
Status: COMPLETED
Conditions: Serotonin Syndrome
Interventions: DRUG: Group R+AD Rasagiline + Antidepressant|DRUG: Group R Rasagiline|DRUG: Group AD Anti-PD + Antidepressant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Valerian on Sleep in Healthy Older Adults
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders
Interventions: DIETARY_SUPPLEMENT: Valerian root extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Nutritional Supplement on Vasomotor Symptoms in Women
Status: COMPLETED
Conditions: Menopause
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: S-equol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Parental Involvement During Venipuncture to Reduce Venipuncture Pain and Anxiety in Children With Cancer
Status: COMPLETED
Conditions: Anxiety|Cancer|Child|Nursing|Pain
Interventions: BEHAVIORAL: parent involvement application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Influence of Complex Correction of Dental and Musculoskeletal Systems on the Frequency of Relapses of Functional Disorders in Patients With Dental Pathologies.
Status: NOT_YET_RECRUITING
Conditions: Malocclusion|Musculoskeletal Disorder
Interventions: PROCEDURE: at correcting malocclusions or restoring the integrity of the dentition|PROCEDURE: comprehensive treatment, including not only dental correction of bite or restoration of the integrity of the dentition, but also correction of disorders of the musculoskeletal system.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile Mental Health Stigma Reduction Intervention Among Black Adults
Status: RECRUITING
Conditions: Anxiety|Depression|Health Knowledge, Attitudes, Practice|Stigmatization|Mobile Phone Use
Interventions: BEHAVIORAL: Video Intervention 1|BEHAVIORAL: Video Intervention 2|BEHAVIORAL: Video Intervention 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Randomized Controlled Trial Comparing Embryonic Quality in rFSH Versus hMG in IVF Protocol With GnRH Antagonist
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: rFSH|DRUG: HMG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Automatic Tourniquets for Soldiers During Wartime
Status: RECRUITING
Conditions: Trauma Injury|Hemorrhage Wound
Interventions: DEVICE: Occlusion of blood flow diagnosed by Point of Care UltraSound (POCUS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: The Role of Psychosocial and Other Quality of Life Parameters in Evaluating Functional Changes Prior to and Following Laser In-situ Keratomileusis (LASIK)Changes Laser In-situ Keratomileusis (LASIK)
Status: WITHDRAWN
Conditions: Keratomileusis, Laser In Situ
Interventions: BEHAVIORAL: Role of psychosocial and quality of life parameters prior to and following LASIK.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety Evaluation of Biatain Ibu in Painful Chronic Venous Leg Ulcers
Status: COMPLETED
Conditions: Leg Ulcers
Interventions: DEVICE: Biatain Ibu|DEVICE: Local best practice
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Effects of Agomelatine for Poststroke Depression
Status: UNKNOWN
Conditions: Depression|Acute Ischemic Stroke
Interventions: DRUG: Agomelatine|DRUG: Placebo Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Stereotactic Radiation in Vestibular Schwannoma
Status: UNKNOWN
Conditions: Vestibular Schwannoma
Interventions: RADIATION: stereotactic radiotherapy|RADIATION: stereotactic radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Claudication With a Peristaltic Pulse Pneumatic Device
Status: UNKNOWN
Conditions: Intermittent Claudication
Interventions: DEVICE: Peristaltic pulse PCD|OTHER: Exercise and lifestyle counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Fat-soluble Vitamins Supplementation on Common Complications and Neural Development in Very Low Birth Weight Infants
Status: UNKNOWN
Conditions: Vitamin A Deficiency|Vitamin D Deficiency|Vitamin E Deficiency|Very Low Birth Weight Infants|Bronchopulmonary Dysplasia|Anemia|Sepsis
Interventions: DRUG: High dose of fat-Soluble Vitamin|DRUG: Conventional dose of fat-Soluble Vitamin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Incorporating Ecological Momentary Assessment and Personalized Telephone Support Into Group-Based Exercise Intervention for Depressive Symptoms
Status: RECRUITING
Conditions: Depression
Interventions: BEHAVIORAL: Group-based exercise intervention with EMA and personalized telephone support (SUP)|BEHAVIORAL: Group-based exercise intervention (EXE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Sleep and Mood in the Peri-menopause
Status: NOT_YET_RECRUITING
Conditions: Menopause|Insomnia
Interventions: DRUG: Estrogens and Progestogens|BEHAVIORAL: Cognitive behavioral therapy for insomnia (CBTi), and circadian rhythm therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carbohydrate Restriction for Gestational Diabetes Mellitus
Status: COMPLETED
Conditions: Gestational Diabetes Mellitus (GDM)
Interventions: BEHAVIORAL: Low CHO|DIETARY_SUPPLEMENT: High CHO diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Implementing a Skills Training Evidence-Based Treatment for Posttraumatic Stress Disorder in Primary Care
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: STAIR-PC Group|BEHAVIORAL: WebSTAIR Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy/Safety of Cilnidipine Plus Valsartan Versus Valsartan in Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: valsartan 160mg, cilnidipine 10mg, cilinidipine 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metformin Use to Reduce Disparities in Newly Diagnosed Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer Stage|Insulin Resistance|Racial Bias
Interventions: DRUG: Metformin Extended Release Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cryolipolisis for Abdomen and Flank Fat Reduction
Status: COMPLETED
Conditions: Subcutaneous Fat Disorder
Interventions: DEVICE: Conventional Cryolipolysis|DEVICE: Contrast Cryolipolysis|DEVICE: Reperfusion Cryolipolysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficiency of Canine Retraction Using Different Reactivation Intervals
Status: UNKNOWN
Conditions: Class II Division 1 Malocclusion|Class III Malocclusion|Bimaxillary Protrusion|Crowding, Tooth
Interventions: PROCEDURE: Canine retraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant FOLFOX Chemotherapy for Patients With Locally Advanced Colon Cancer
Status: RECRUITING
Conditions: Colon Cancer
Interventions: DRUG: Neoadjuvant FOLFOX|DRUG: Conventional adjuvant FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of ACT-541468 (Daridorexant) in Adult and Elderly Subjects Suffering From Difficulties to Sleep
Status: COMPLETED
Conditions: Insomnia Disorder
Interventions: DRUG: Daridorexant|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Collaborative Nurse-pharmacist Counseling for Self-administered Biologics
Status: WITHDRAWN
Conditions: Medication Adherence|Medication Nonadherence|Adverse Drug Event
Interventions: BEHAVIORAL: Collaborative nurse-pharmacist counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Short-Term Exposure to Lipophilic Anti-proliferative Drugs Delivered by Angiographic Contrast Media
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Implantation of a bare metal stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Docosahexanoic Acid on Neurocognitive Impairment in HIV-infected Patients
Status: UNKNOWN
Conditions: Neurocognitive Impairment
Interventions: DRUG: Docosahexaenoic acid (DHA) capsules|DIETARY_SUPPLEMENT: Soy oil capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Options for CRAB
Status: NOT_YET_RECRUITING
Conditions: Infections, Bacterial|Sepsis Bacterial
Interventions: DRUG: Fosfomycin|DRUG: Eravacycline|DRUG: ampicillin/sulbactam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Operative Hysteroscopy and Ultrasound Guided Vacuum Aspiration Versus Blind Vacuum Aspiration for the Treatment of Missed Abortion
Status: UNKNOWN
Conditions: Missed Abortion
Interventions: DEVICE: hystroscopy|DEVICE: ultrasound|PROCEDURE: Aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Small-Volume, Patient-Specific, Balanced Hypertonic Fluid Protocol Validation
Status: WITHDRAWN
Conditions: Cerebral Edema|Saline Solution, Hypertonic
Interventions: DRUG: 3% Sodium Chloride|DRUG: 23.4% Sodium Chloride|DRUG: 8.4% Sodium Bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Statins for the Primary Prevention of Heart Failure in Patients Receiving Anthracycline Pilot Study
Status: UNKNOWN
Conditions: Cancer|Heart Failure|Cardiotoxicity
Interventions: DRUG: Atorvastatin|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety And Efficacy Of GSK233705 Plus Salmeterol Compared With 2 Active Comparators And Placebo In Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: salmeterol|DRUG: tiotropium|DRUG: GSK233705
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Safety Study of MRX-2843 in Adults With Relapsed/Refractory Advanced and/or Metastatic Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Cancer|Metastatic Cancer|Neoplasms|Neoplasm Metastasis|Neoplastic Processes|Pathologic Processes
Interventions: DRUG: MRX-2843
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bovine Colostrum as a Human Milk Fortifier for Preterm Infants
Status: COMPLETED
Conditions: Feeding Intolerance|Necrotizing Enterocolitis|Postnatal Growth|Late-Onset Neonatal Sepsis
Interventions: DIETARY_SUPPLEMENT: Bovine Colostrum|DIETARY_SUPPLEMENT: FM85
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Effectiveness of the PXL-Platinum 330 System for Cornea Crosslinking in Eyes With Cornea Thinning
Status: RECRUITING
Conditions: Keratoconus
Interventions: DEVICE: PXL Platinum 330 system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Tolerability and Pharmacokinetics of rhNGF Eye Drops in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: rhNGF 0.5 µg/mL Sentinel|DRUG: rhNGF 5 µg/mL Sentinel|DRUG: rhNGF 20 µg/mL Sentinel|DRUG: rhNGF 20 µg/mL Part A|DRUG: rhNGF 60 µg/mL Part A|DRUG: rhNGF 180 µg/mL Part A|DRUG: rhNGF 20 µg/mL Part B|DRUG: rhNGF 60 µg/mL Part B|DRUG: rhNGF 180 µg/mL Part B|DRUG: Placebo Part A|DRUG: Placebo Part B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of a Medication Disposal Program in Primary Care
Status: COMPLETED
Conditions: Opioid-Related Disorders
Interventions: BEHAVIORAL: Education|BEHAVIORAL: Education with Reminder|BEHAVIORAL: Education + Disposal Bag|BEHAVIORAL: Education + Disposal Bag with Reminder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Investigate the Management of Hypertension and Efficacy of AZD2171 in Patients With Advanced Solid Tumours
Status: COMPLETED
Conditions: Tumors
Interventions: DRUG: AZD2171
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Triamcinolone Acetonide as an Adjuvant to Pre-emptive Scalp Infiltration for Relief of Post-craniotomy Pain in Adults
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: The TR group|DRUG: The R group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ADITEC FLU 2 STUDY: Understanding the Genetics Basis for Immune Responses to Flu Vaccines in Children and Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: MF59 - ATIV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Comparative Clinical and Radiographic Study Of Collagen Based Pulpotomy in Cariously Exposed Vital Primary Molars
Status: NOT_YET_RECRUITING
Conditions: Dental Caries in Children
Interventions: OTHER: MTA based pulpotomy|OTHER: Collagen based pulpotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chronic Alcohol, Stress Inflammatory Response and Relapse Risk
Status: COMPLETED
Conditions: Alcohol Dependence|Depressive Symptomatology
Interventions: BEHAVIORAL: Personal Stress Imagery|BEHAVIORAL: Neutral Imagery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Defining the Temporal Changes in the Acute Phase Response During Graded Exercise: A Prospective Study
Status: ENROLLING_BY_INVITATION
Conditions: Acute Phase Response
Interventions: OTHER: Graded Exercise|OTHER: Marathon participation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Immunogenicity of a Trivalent Influenza Vaccine When Administered to Elderly Subjects
Status: COMPLETED
Conditions: Human Influenza
Interventions: BIOLOGICAL: Adjuvanted Trivalent Influenza Virus Vaccine (aTIV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Emricasan, an Oral Caspase Inhibitor, in Subjects With NASH Cirrhosis and Severe Portal Hypertension
Status: COMPLETED
Conditions: Cirrhosis|Portal Hypertension|Non-alcoholic Steatohepatitis
Interventions: DRUG: Emricasan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: eXalt3: Study Comparing X-396 (Ensartinib) to Crizotinib in ALK Positive Non-Small Cell Lung Cancer (NSCLC) Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: X-396 (ensartinib)|DRUG: crizotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Two Regional Techniques for Bariatric Sleeve Gastrectomy
Status: RECRUITING
Conditions: Bariatric Surgery Candidate|Weight Loss|Surgery
Interventions: PROCEDURE: Bilateral Erector Spinae Plane Block|PROCEDURE: Abdominal Wall Blocks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Dietary Supplementation on Serum Protein Glycosylation
Status: RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Monosaccharide Powder|DIETARY_SUPPLEMENT: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PEG-rhG-CSF in Elderly Patients With Small Cell Lung Cancer Receiving Chemotherapy
Status: UNKNOWN
Conditions: Small Cell Lung Cancer|PEG-rhG-CSF
Interventions: DRUG: PEG-rhG-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Open Study on the Preventive Effect of Early Mizoribine Conversion on BKV Nephropathy in Renal Transplant Recipients
Status: UNKNOWN
Conditions: Kidney Transplant Recipients|BK Virus
Interventions: DRUG: Mizoribine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of FOLFOX6 With Bevacizumab for Biliary System Carcinoma
Status: TERMINATED
Conditions: Biliary Tract Cancer
Interventions: DRUG: "Bevacizumab" in combination with "modified FOLFOX6".
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of BNC210 in Acute, As-needed Treatment of Anxiety in Social Anxiety Disorder - 1
Status: RECRUITING
Conditions: Social Anxiety Disorder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic hMSC Injection in Patients With Hypoplastic Left Heart Syndrome
Status: TERMINATED
Conditions: Hypoplastic Left Heart Syndrome
Interventions: DRUG: Allo-hMSCs|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Combination Vitamin D With Standard of Care in Egyptian Patients With Untreated Chronic Hepatitis C
Status: WITHDRAWN
Conditions: Chronic Hepatitis C
Interventions: DRUG: Vitamin D + Pegylated Interferon Alpha 2b + Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Stress on Performance of Neonatal Endotracheal Intubation
Status: COMPLETED
Conditions: Neonatal Intubation Performance
Interventions: OTHER: High stress|OTHER: Low stress|OTHER: Endotracheal intubation on mannequin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Vibration Enhances Diabetic ULCER Healing
Status: NOT_YET_RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: Low Magnitude High Frequence Vibration Platform|OTHER: Conventional Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rebeccamycin Analog in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia, or Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Blastic Phase Chronic Myelogenous Leukemia|Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndromes|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Refractory Anemia With Excess Blasts|Refractory Anemia With Excess Blasts in Transformation|Relapsing Chronic Myelogenous Leukemia|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndromes
Interventions: DRUG: becatecarin|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Horizons in the Treatment of Vitreous Floaters
Status: UNKNOWN
Conditions: Other Vitreous Opacities, Bilateral
Interventions: DEVICE: Ultra Q Reflex YAG laser (Ellex)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Percutaneous Electrolysis in the Treatment of Lateral Epicondylalgia. A Single-Blind Randomized Controlled Trial.
Status: COMPLETED
Conditions: Epicondylitis
Interventions: OTHER: Epte group|OTHER: Dry needling group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Next-Generation Sequencing for Pathogen Detection and Quantification in Children With Musculoskeletal Infections
Status: COMPLETED
Conditions: Musculoskeletal Infection|Acute Hematogenous Osteomyelitis|Septic Arthritis|Osteomyelitis|Pyomyositis
Interventions: DIAGNOSTIC_TEST: Karius Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Dose Escalation Study to Assess PK, Safety and Tolerability of INC280 When Taken With Food in cMET Dysregulated Advanced Solid Tumors.
Status: COMPLETED
Conditions: cMET Dysegulation Advanced Solid Tumors
Interventions: DRUG: INC280
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Discontinuation of TNF-alpha Inhibitors in Patients With Spondyloarthritis
Status: TERMINATED
Conditions: SPONDYLOARTHRITIS
Interventions: DRUG: Discontinuation of TNF-alpha inhibitor and re-starting it if flare-up in disease activity (etanercept or adalimumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SGLT2 Inhibition in Older Obese Adults With Pre-diabetes
Status: COMPLETED
Conditions: Aging
Interventions: DRUG: Dapagliflozin 10 mg|BEHAVIORAL: Nutritional counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of a Multi-ingredient on Visceral Adiposity and Non-alcoholic Fatty Liver Disease in Individuals With Abdominal Obesity
Status: COMPLETED
Conditions: Visceral Obesity|Non-Alcoholic Fatty Liver Disease
Interventions: DIETARY_SUPPLEMENT: Multi-ingredient of L-histidine, L-serine, L-carnosine and N-Acetylcysteine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial on Topotect® (Dexrazoxane) in the Treatment of Accidental Extravasation of Anthracyclines
Status: COMPLETED
Conditions: Extravasation
Interventions: DRUG: Dexrazoxane
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Teledermatology vs. Face-to-Face Visits in the Follow-Up of Patients With Acne
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DEVICE: Teledermatology|OTHER: Face-to-face consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Upper Extremity Aerobic Exercise Training in Patients With Interstitial Lung Disease
Status: RECRUITING
Conditions: Interstitial Lung Disease
Interventions: OTHER: Upper extremity high-intensity interval aerobic exercise training|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Rituximab in Combination With Methotrexate in Methotrexate-Naive Patients With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: folate|DRUG: methotrexate|DRUG: methylprednisolone|DRUG: placebo|DRUG: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Drinkable Yogurt Enriched in Proteins and Fibers on Satiety
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: Satiety
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans
Status: RECRUITING
Conditions: Frailty
Interventions: BEHAVIORAL: Center based attention control|BEHAVIORAL: Center based HIIT|BEHAVIORAL: Home based HIIT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety of Oka Varicella in Children Prior to Solid Organ Transplantation
Status: COMPLETED
Conditions: Organ Transplantation|Immunosuppression
Interventions: BIOLOGICAL: varicella vaccine (VARIVAX)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Post Aerobic Exercise Hot Water Immersion on Physiological and Perceptual Responses in Physically Inactive Middle-aged Adults
Status: COMPLETED
Conditions: Healthy Aging
Interventions: DEVICE: Post exercise hot water immersion|DEVICE: Exercise|DEVICE: Hot water immersion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ABI-007 and Bevacizumab in Treating Women With Recurrent or Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: paclitaxel albumin-stabilized nanoparticle formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effects of Tiotropium Bromide on Chronic Obstructive Pulmonary Disease (COPD) During Exercise
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: tiotropium bromide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Levobupivacaine Prolonged Wound Infusion for Postoperative Pain Relief After Breast Surgery
Status: UNKNOWN
Conditions: Acute Pain|Chronic Pain|Wound Infusion|Mastectomy
Interventions: DRUG: Levobupivacaine PCIA (Patient Controlled Intrawound Analgesia)|DRUG: saline|DRUG: Levobupivacaine continuous infusion|DEVICE: intrawound infusion catheter|DRUG: morphine|DRUG: Patrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lung US for PEEP Optimization in Robotic Radical Prostatectomy or Cystectomy Patients
Status: RECRUITING
Conditions: Prostate Cancer|Urinary Bladder Cancer|Surgery|Positive End Expiratory Pressure|Lung Ultrasound
Interventions: PROCEDURE: Lung Ultrasound - guided Stepwise PEEP|PROCEDURE: Standard Ventilation Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Paliperidone Palmitate Efficacy and Safety in Bipolar Disorder Complicated by Alcoholism
Status: WITHDRAWN
Conditions: Bipolar Disorder
Interventions: DRUG: Paliperidone Palmitate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib, Docetaxel, and Radiation Therapy in Stage III or Stage IV Squamous Cell Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: docetaxel|DRUG: erlotinib hydrochloride|GENETIC: fluorescence in situ hybridization|GENETIC: polymerase chain reaction|OTHER: immunoenzyme technique|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|OTHER: pharmacological study|PROCEDURE: therapeutic conventional surgery|RADIATION: intensity-modulated radiation therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tetrabenazine for Partial Responders
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Tetrabenazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A System of Safety (SOS)
Status: COMPLETED
Conditions: Suicide
Interventions: BEHAVIORAL: Suicide Risk Screening|BEHAVIORAL: Safety Planning|BEHAVIORAL: Care transition facilitation|BEHAVIORAL: A Lean Implementation Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Pharmacological Interaction Between Pindolol and MDMA (3,4-Methylenedioxymethamphetamine)
Status: COMPLETED
Conditions: Mood Disorder|Substance-Related Disorders|Amphetamine-Related Disorders
Interventions: DRUG: MDMA|DRUG: Pindolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nivolumab in Treating Patients With Stage IV or Recurrent Lung Cancer With High Mutation Loads
Status: WITHDRAWN
Conditions: Recurrent Non-Small Cell Lung Carcinoma|Stage IV Non-Small Cell Lung Cancer
Interventions: BIOLOGICAL: Nivolumab|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Tolerability, Safety, Pharmacokinetics and Pharmacodynamics of Alirocumab SAR236553 (REGN727)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: alirocumab SAR236553 (REGN727)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiotherapy (SBRT) Followed by Immunotherapy in Liver Cancer
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Quality of Life of Children With Cancer Through Psychosocial Screening
Status: COMPLETED
Conditions: Cancer
Interventions: OTHER: Summary of psychosocial risk factors|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy Study of CEP-1347 in the Treatment of Parkinson's Disease
Status: TERMINATED
Conditions: Parkinson Disease
Interventions: DRUG: CEP-1347 10mg|DRUG: CEP1347 25mg|DRUG: CEP-1347 50mg|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation Protocols for Isolation of Analytes From Urine for Future Oncology Applications
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Prostate Cancer|Urine|Liquid Biopsy
Interventions: DEVICE: Colli-Pee UAS devices
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression.
Status: COMPLETED
Conditions: Major Depression|Bipolar I Disorder|Bipolar II Disorder|Unipolar Depression
Interventions: DRUG: Ketamine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: DUR-928 in Subjects With SARS-CoV-2 With Acute Lung, Liver or Kidney Injury
Status: TERMINATED
Conditions: SARS-CoV-2
Interventions: DRUG: DUR-928|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity Study of Recombinant Human Papillomavirus Vaccine(6,11,16,18,31,33,45,52,58 Type)(E.Coli)
Status: COMPLETED
Conditions: Condylomata Acuminata|Cervical Cancer
Interventions: BIOLOGICAL: HPV Vaccine,270μg/1.0ml|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Sweet spoT for cArdiac Rhythm monitorinG After sTrokE
Status: NOT_YET_RECRUITING
Conditions: Stroke|Atrial Fibrillation
Interventions: DEVICE: Implantable Loop Recorder|OTHER: Quality of life survey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vaccine Therapy Plus Interleukin-2 With or Without Interferon Alfa-2b in Treating Patients With Stage III Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: liposomal interleukin-2|BIOLOGICAL: polyvalent melanoma vaccine|BIOLOGICAL: recombinant interferon alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of the Subcutaneous Injection of a Viscous Antibody Solution With Recombinant Human Hyaluronidase
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Hylenex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Reproducibility of Strength Testing and Functional Testing of the Hip for the Return to Sport of Patients Activated by a Femoroacetabular Impingement: Comparison Between a Group of Patients and a Group of Healthy Controls
Status: UNKNOWN
Conditions: Femoroacetabular Impingement
Interventions: OTHER: Functional Tests
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab
Status: COMPLETED
Conditions: Adult Acute Lymphocytic Leukemia
Interventions: DRUG: Cyclophosphamide|DRUG: Dexamethasone / Prednisolone|DRUG: Vincristine|DRUG: Daunorubicin|DRUG: Asparaginase|DRUG: Methotrexate|DRUG: Cytarabine|DRUG: Mercaptopurine|DRUG: G-CSF|DRUG: Vindesine|DRUG: VP16|DRUG: Adriamycin|DRUG: Thioguanine|DRUG: VM26|DRUG: Rituximab|PROCEDURE: CNS irradiation|PROCEDURE: Mediastinal irradiation (if residual TU)|PROCEDURE: Stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smart Lighting for Nursing Home Residents With Dementia
Status: COMPLETED
Conditions: Alzheimer's Disease and Related Dementias
Interventions: DEVICE: Smart Ambient Bright Light (SABL)|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Probiotic (L.Reuteri) Survival in Presence of Prebiotic Galacto-oligosaccharides
Status: TERMINATED
Conditions: Healthy
Interventions: OTHER: TEST1|OTHER: TEST 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Reboxetine and Methylphenidate Treatment on Attentional, Sensory and Emotional Dysregulation in Adults With PTSD
Status: RECRUITING
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: Methylphenidate|DRUG: Reboxetine|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Multicenter Registry of Patients With Sleep Disordered Breathing Treated With DreamStation BiPAP autoSV.
Status: COMPLETED
Conditions: Central Sleep Apnea|Mixed Sleep Apnea|Cheyne-Stokes Respiration|Complex Sleep Apnea
Interventions: DEVICE: DreamStation BiPAP autoSV
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Effectiveness Study of Dragonfly System for Functional Mitral Regurgitation
Status: RECRUITING
Conditions: Mitral Regurgitation Functional
Interventions: DEVICE: Dragonfly Transcatheter Mitral Valve Repair System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simplifying Hepatitis C Pathways for People Who Inject Drugs in Armenia, Georgia, and Tanzania
Status: NOT_YET_RECRUITING
Conditions: Hepatitis C|RDT
Interventions: DRUG: sofosbuvir/velpatasvir (SOF/VEL)|DIAGNOSTIC_TEST: Shortened read time of rapid diagnostic test for hepatitis C virus.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laos Out-Of-Pocket Costs: an Observational Study on the Impact of Severe Childhood Illness on the Health, Wealth and Wellbeing of Household Members in Laos
Status: COMPLETED
Conditions: Health Care Economics|Child Health|Cost of Illness|Burden of Illness
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Different Infusion Volume on Perioperative Bladder and Blood Volume in Patients Undergoing Daytime Surgery.
Status: COMPLETED
Conditions: Cholecystolithiasis and Thyroid Nodule
Interventions: DRUG: Ringer's solution acetate|DRUG: Ringer's solution acetate|DRUG: Ringer's solution acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT