pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Inflammation and Coronary Endothelial Function
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Methotrexate|DRUG: Colchicine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate Insulin in the Blood After Inhalation of a Dry Powder Insulin Formulation (Called Technosphere®/Insulin) in Non-diabetic Patients With & Without Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Technosphere®/Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of Docetaxel Vs Vinorelbine in Elderly Patients With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Patients were randomized to receive either docetaxel 60 mg/m2 on day 1 or vinorelbine 25 mg/m2 on days 1and 8, repeated every 21 days over four cycles.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ferric Carboxymaltose With or Without EPO Reducing Red-cell Transfusion Packs in Hip Fracture Perioperative Period
Status: COMPLETED
Conditions: Hip Fractures
Interventions: DRUG: Ferric carboxymaltose|DRUG: Erythropoietin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Canagliflozin on Renal and Cardiovascular Outcomes in Participants With Diabetic Nephropathy
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Diabetic Nephropathy
Interventions: DRUG: Canagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Efficacy and Safety of YVOIRE Classic Plus Versus YVOIRE Classic in Nasolabial Fold Injection
Status: COMPLETED
Conditions: Wrinkles
Interventions: DEVICE: HA IDF plus|DEVICE: HA IDF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Surfactants on the Skin Microbiome
Status: COMPLETED
Conditions: Healthy Skin
Interventions: OTHER: Control Hand Soap|OTHER: Benzalkonium Chloride Soap|OTHER: Triclocarban Soap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Metformin in Women With Type 2 Diabetes in Pregnancy Trial
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Metformin|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Chemo-mechanical Caries Removal Agent (BRIX3000®) in Primary Molars
Status: COMPLETED
Conditions: Dental Caries
Interventions: PROCEDURE: The chemomechanical caries removal agent "BRIX3000®" in group (1A)|PROCEDURE: The traditional surgical treatment in group (1C)|PROCEDURE: The chemomechanical caries removal agent "Carie-CareTM" in group (2B)|PROCEDURE: The traditional surgical treatment in group (2C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postprandial Inflammatory Response in Healthy Men: Effect of Dietary Fat Source, Obesity and Age
Status: COMPLETED
Conditions: Healthy|Obesity
Interventions: OTHER: Mashed potatoes|OTHER: Mashed potatoes + Oleic acid|OTHER: mashed potatoes + Palmitic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Efficacy and Safety of Arbidol in Reducing the Frequency of AECOPD.
Status: ENROLLING_BY_INVITATION
Conditions: COPD Patients
Interventions: DRUG: Arbidol|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pediatric Taste Test Study of Cefdinir (Omnicef) Versus Amoxicillin Antibiotic Suspension Medications
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: cefdinir (Omnicef)|DRUG: amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Increased Peri-implant Keratinized Mucosal Thickness at Different Operative Times
Status: UNKNOWN
Conditions: Dental Implants|Peri-Implantitis
Interventions: PROCEDURE: Subepithelial connective tissue graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemoradiotherapy Plus Anti-PD1 in Recurrent NPC: A Multicenter, Open-label, Randomised, Controlled, Phase III Trial
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Toripalimab|DRUG: Chemotherapy|RADIATION: Intensity modulated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief Psychotherapies for Emotional Disorders in Primary and Secondary Care
Status: COMPLETED
Conditions: Emotional Disorder
Interventions: BEHAVIORAL: Brief transdiagnostic cognitive-behavioral therapy|DRUG: Pharmacological treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of the Antihistamine Injection to Prevent Paradoxical Reaction During Sedative Endoscopy
Status: UNKNOWN
Conditions: Endoscopy
Interventions: DRUG: Chlorpheniramine and midazolam|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of QL1706 Combined With Platinum-containing Chemotherapy in Adjuvant Treatment of Stage II-IIIB Non-small Cell Lung Cancer After Complete Surgical Resection.
Status: NOT_YET_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: QL1706 injection|DRUG: Vinorelbine Tartrate|DRUG: Paclitaxel|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Pemetrexed|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigate the Effect of AZD1656 on the Pharmacokinetics of Sitagliptin in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: AZD1656|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Awake Intraoperative Language Mapping and Chinese Probabilistic Map Construction
Status: UNKNOWN
Conditions: Glioma
Interventions: PROCEDURE: Intraoperative direct cortical electrical stimulation|PROCEDURE: Intraoperative direct subcortical electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Thinking Healthy Program-Technology Assisted (THP-TA)
Status: ACTIVE_NOT_RECRUITING
Conditions: Perinatal Depression|Depression, Postpartum
Interventions: BEHAVIORAL: Technology assisted Thinking Healthy Program (THP-TA)|BEHAVIORAL: Standard Thinking Healthy Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Epcoritamab in Previously Treated WM
Status: NOT_YET_RECRUITING
Conditions: Waldenstrom Macroglobulinemia|B-Cell Lymphoproliferative Disorder
Interventions: DRUG: Epcoritamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Electroacupuncture for Gastrointestinal Motility Disorders
Status: TERMINATED
Conditions: Gastroparesis
Interventions: DEVICE: Transcutaneous Electroacupuncture|DEVICE: Sham TEA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cabazitaxel Versus the Switch to Alternative AR-targeted Agent (Enzalutamide or Abiraterone) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Patients Previously Treated With Docetaxel and Who Rapidly Failed a Prior AR-targeted Agent
Status: COMPLETED
Conditions: Prostate Cancer Metastatic
Interventions: DRUG: cabazitaxel XRP6258|DRUG: enzalutamide|DRUG: abiraterone acetate|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cholesterol Lowering Treatment With Psyllium Husks and Isolated Soy Protein in Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Psyllium husks|DIETARY_SUPPLEMENT: Isolated soy protein|DIETARY_SUPPLEMENT: Isolated whey protein|OTHER: Microcrystalline cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Deferoxamine In the Treatment of Aneurysmal Subarachnoid Hemorrhage (aSAH)
Status: RECRUITING
Conditions: Aneurysmal Subarachnoid Hemorrhage
Interventions: DRUG: Deferoxamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: How do You Take Your Coffee Before Anesthesia
Status: COMPLETED
Conditions: Anesthesia|Aspiration|Fasting
Interventions: OTHER: Addition of half and half to coffee|OTHER: Addition of non-dairy creamer to coffee|OTHER: Black
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy Study of T2 Versus AZA to Maintain Clinical and Endoscopic Remission in Postoperative Crohn's Disease
Status: UNKNOWN
Conditions: Crohn's Disease
Interventions: DRUG: T2|DRUG: Azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Combined Modified RNA Vaccine Candidate Against COVID-19 and Influenza.
Status: ACTIVE_NOT_RECRUITING
Conditions: Influenza|COVID-19
Interventions: BIOLOGICAL: Influenza and COVID-19 Combination A|BIOLOGICAL: Licensed influenza vaccine|BIOLOGICAL: COVID-19 Vaccine|BIOLOGICAL: Influenza and COVID-19 Combination B|BIOLOGICAL: Placebo|BIOLOGICAL: Investigational influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Combination of Adebrelimab and TP Regimen for Neoadjuvant Therapy in Patients With Stage IVB Oral Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Clinical IVb Stage Oral Squamous Cell Carcinomas Patients
Interventions: DRUG: Adebrelimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Functional Outcome After Lateral Trochlear Lengthening Osteotomy Lateral Trochlear Lengthening Osteotomy
Status: COMPLETED
Conditions: Patellar Instability
Interventions: OTHER: Collection of clinical measurements|OTHER: Collection of data for muscle strength|OTHER: Collection of EMG Data|OTHER: Collection of Clinical Scores|OTHER: Collection of Imaging Data - Radiological measurements
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: NACOS - The Effect of N-acetylcystein for Depressive Symptoms in Patients Suffering From Bipolar Depression
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: N-acetylcysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab Combined With Chemotherapy Neoadjuvant Therapy of Biliary Tract Cancer
Status: RECRUITING
Conditions: Resectable Biliary Tract Cancer
Interventions: DRUG: Cisplatin|DRUG: Gemcitabine|DRUG: Nab-paclitaxel|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ORIC-I: Optimizing Recovery From Intensive Care: Mechanical Ventilation and Delirium
Status: TERMINATED
Conditions: Delirium
Interventions: DRUG: haloperidol|OTHER: Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine With or Without Imatinib Mesylate in Treating Patients With Metastatic or Unresectable Kidney Cancer
Status: TERMINATED
Conditions: Kidney Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: imatinib mesylate|GENETIC: gene expression analysis|GENETIC: protein expression analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Modifications of Heart Murmurs and Cardiac Output During Fever
Status: UNKNOWN
Conditions: Heart Murmurs|Fever
Interventions: DEVICE: Auscultation using an electronic stethoscope (EKO CORE 4)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM)
Status: NOT_YET_RECRUITING
Conditions: Recurrent Glioblastoma
Interventions: BIOLOGICAL: pp65 RNA loaded lipid particles, pp65 RNA-LPs (Drug Product 1 or DP1)|BIOLOGICAL: RNA loaded lipid particles, RNA-LPs (Drug Product 2 or DP2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Piroxicam as a Perioperative Analgesic for Patients Undergoing Fixation of Maxillofacial Fractures
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Piroxicam group|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Epoprostenol for Injection in Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: ACT-385781A (Actelion Epoprostenol)|DRUG: Flolan®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogenic Adipose-Derived Mesenchymal Progenitor Cells for the Treatment of Knee Osteoarthritis
Status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DRUG: Mesenchymal progenitor cells|DRUG: Sodium Hyaluronate Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Modulation of Gut Microbiota in End-stage Renal Disease
Status: WITHDRAWN
Conditions: End-stage Renal Disease
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of MiniMed™ 640G Insulin Pump With SmartGuard™ in Prevention of Low Glucose Events in Adults With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: MiniMed™640G and Suspend before low|DEVICE: MiniMed™640G
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nirvana Super Pro Supplementation in Orthopedic Surgery Patients
Status: RECRUITING
Conditions: Arthropathy of Knee|Arthropathy of Hip
Interventions: DIETARY_SUPPLEMENT: Supplementation with Nirvana Super Pro Liquid Supplements|DIETARY_SUPPLEMENT: Non-Supplementation Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Effectiveness of Pregnancy Failure Management Regimens
Status: COMPLETED
Conditions: Spontaneous Abortion
Interventions: DRUG: Misoprostol|DRUG: Mifepristone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Exercise and Insole on Foot Posture, Plantar Force Distribution, and Balance in Individuals With Pes Planus
Status: COMPLETED
Conditions: Pes Planus
Interventions: OTHER: Exercise|OTHER: Orthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Surgery for Patients With Asymptomatic Aortic Stenosis
Status: UNKNOWN
Conditions: Aortic Valve Stenosis|Aortic Valve Surgery
Interventions: OTHER: Early surgical aortic valve replacement|OTHER: Delayed Surgical aortic valve replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Salvage Therapy to Treat Patients With Granulomatosis With Polyangiitis
Status: NOT_YET_RECRUITING
Conditions: Granulomatosis With Polyangiitis|Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis
Interventions: DRUG: Rituximab|DRUG: Tocilizumab|DRUG: Abatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study Adding Ascorbate to Chemotherapy and Radiation Therapy for NSCLC
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung|Non-Small Cell Lung Cancer|Nonsmall Cell Lung Cancer|Non-Small-Cell Lung Carcinoma|NSCLC
Interventions: DRUG: Radiation Therapy|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Ascorbic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extra Short Implants Brånemark System® RP Ø4.5x4.5 mm Implants
Status: UNKNOWN
Conditions: Healthy Volunteers With Severely Resorbed Jaws in Need of an Implant Supported Restoration
Interventions: DEVICE: extra short implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Controlled, Blinded Study to Validate the Diagnostic Accuracy and Assess the Clinical Utility of a Host-response Based Diagnostic Tool for Distinguishing Between Bacterial and Viral Etiologies in Pediatric Patients Presenting to the ED With Suspicion of Acute Infection
Status: UNKNOWN
Conditions: Viral Infection|Bacterial Infections|Antibiotic Misuse|Host Response Diagnostics
Interventions: DIAGNOSTIC_TEST: ImmunoXpert™
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sintilimab (One Anti-PD-1 Antibody) Plus Low-dose Bevacizumab for ctDNA-level-relapse and Clinical-relapse Glioblastoma
Status: NOT_YET_RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: Tislelizumab plus Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of the Effect of Epidural Dexmedetomidine Versus Fentanyl Added to Ropivacaine in Pediatric Orthopedic Surgery
Status: COMPLETED
Conditions: Congenital Skelectal Anomaly
Interventions: DRUG: fentanyl|DRUG: dexmedetomidine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vestibular Therapy in Alzheimer's Disease
Status: RECRUITING
Conditions: Vestibular Diseases|Vestibular Disorder|Alzheimer Disease
Interventions: BEHAVIORAL: Vestibular physical therapy|BEHAVIORAL: Active control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tiotropium on Airway Diameter in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium inhalation powder capsules|DRUG: Placebo inhalation powder capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Nonmyeloablative Haploidentical Transplant Followed by MLN9708
Status: COMPLETED
Conditions: Acute Leukemia|Chronic Leukemia|Myelodysplastic Syndrome|Lymphomas|Multiple Myeloma
Interventions: DRUG: MLN9708
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: WILL lOWer Dose Aspirin be Better With Rivaroxaban in Patients With Chronic Coronary Syndromes?
Status: COMPLETED
Conditions: Coronary Syndrome
Interventions: DRUG: Aspirin 75mg|DRUG: Aspirin 20mg|DRUG: Rivaroxaban 2.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Turmeric and Curcumin on Sebum Production
Status: COMPLETED
Conditions: Inflammation; Skin
Interventions: DIETARY_SUPPLEMENT: Turmeric tablets|DIETARY_SUPPLEMENT: Curcumin and Bioperine tablets|DIETARY_SUPPLEMENT: Placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ultrasonography Versus Palpation for Identification of the Cricothyroid Membrane
Status: UNKNOWN
Conditions: Airway Obstruction
Interventions: OTHER: Marking the cricothyroid membrane after ultrasound|PROCEDURE: Marking of the cricothyroid membrane after Palpation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Minocycline to Prevent Acute Kidney Injury After Cardiac Surgery
Status: COMPLETED
Conditions: Kidney Failure, Acute|Acute Kidney Insufficiency
Interventions: DRUG: minocycline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Metoclopramide Versus Erythromycin on on Gastric Residual Volume
Status: COMPLETED
Conditions: Gastric Residual Volume
Interventions: DRUG: Erythromycin (400mg)|DRUG: metoclopramide (10mg)|DIETARY_SUPPLEMENT: naturally flavored water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1, Safety and Tolerability Study of XmAb®541 in Advanced Solid Tumors
Status: RECRUITING
Conditions: Ovarian Cancer|Endometrial Cancer|Germ Cell Tumor|Testicular Germ Cell Tumor|Ovarian Germ Cell Tumor
Interventions: BIOLOGICAL: XmAb541
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maturation of Follicles After Transplantation of Ovarian Tissue Into the Pelvic Wall and the Ovary
Status: TERMINATED
Conditions: Infertility|Ovarian Failure, Premature
Interventions: OTHER: Transplantation into pelvic wall|OTHER: Transplantation into the ovary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Steroid Avoidance and Low-dose CNI by ATG-induction in Renal Transplantation
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Steroid-free low TAC-arm: Thymoglobulin Standard low-TAC arm: Simulect, prednisolon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of KB004 in Subjects With Hematologic Malignancies (Myelodysplastic Syndrome, MDS, Myelofibrosis, MF)
Status: SUSPENDED
Conditions: Myelodysplastic Syndrome (MDS)|Myelofibrosis (MF)
Interventions: DRUG: KB004, Monoclonal Antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional and Physiological Changes Induced by Pinhole Glasses in Presbyopia
Status: UNKNOWN
Conditions: Pinhole
Interventions: DEVICE: Trayner Pinhole Glasses (Trayner Glasses, Ivybridge Devon, U.K.)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Age Related Effects Consuming Phaeodactylum Tricornutum
Status: UNKNOWN
Conditions: Aging|Well Aging
Interventions: DIETARY_SUPPLEMENT: Placebo vegetable bouillon|DIETARY_SUPPLEMENT: microalgae phaeodactylum|DIETARY_SUPPLEMENT: From the Microalgae phaeodactylum the extracted beta-Glucan (especially chrysolaminarin)|DIETARY_SUPPLEMENT: A combination of the vegetable bouillon, the microalgae and the beta-Glucan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Home Blood Pressure Monitoring (MONITOR Study)
Status: COMPLETED
Conditions: Hypertension
Interventions: DEVICE: HBPM|DEVICE: HBPM and Pharmaceutical care|BEHAVIORAL: Pharmaceutical care|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Lenalidomide and Docetaxel in Subjects With Androgen Independent Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Lenalidomide|DRUG: Docetaxel|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Ultrasound Guided Combined Interscalene and Supraclavicular Brachial Plexus Block Versus General Anesthesia for Brachioaxillary Surgery in Renal Failure Patient
Status: COMPLETED
Conditions: Anesthesia
Interventions: DEVICE: combined supraclavicular and interscalene block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Feasibility and Potential Impact of an Individualized Exercise Program Via a Telerehabilitation Device in Chronic Patients: A Pilot Study
Status: NOT_YET_RECRUITING
Conditions: Chronic Disease|Chronic Condition|Stroke Sequelae|Age Problem|Parkinson Disease
Interventions: DEVICE: Telerehabilitation intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Levocetirizine and Fexofenadine
Status: COMPLETED
Conditions: Pruritus|Chronic Urticaria|Allergic Rhinitis
Interventions: DRUG: Levocetirizine Oral Tablet|DRUG: Fexofenadine 60 Mg Oral Tablet|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Study of Pyrotinib in Combination With Trastuzumab in Patients With HER2 Positive Breast Cancer
Status: UNKNOWN
Conditions: HER2-positive Breast Cancer
Interventions: DRUG: Pyrotinib|DRUG: Placebo Oral Tablet|DRUG: Trastuzumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Faecal Microbiota Transplantation in the Treatment of Chronic Pouchitis
Status: TERMINATED
Conditions: Pouchitis|Inflammatory Bowel Diseases|Ulcerative Colitis
Interventions: OTHER: Faecal microbiota transplantation|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of SMS in Improving Antiretroviral Medication Adherence Among Adolescents Living With HIV in Nigeria
Status: COMPLETED
Conditions: HIV Infections
Interventions: BEHAVIORAL: Daily ART-adherence SMS reminder|BEHAVIORAL: Standard Adherence Counselling/Patient experience group chat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Strategies for Coping With Negative Thoughts
Status: COMPLETED
Conditions: Depressive Symptoms|Anxiety|Negative Thinking
Interventions: OTHER: Positive thinking|OTHER: Positive thinking + Mood induction|OTHER: Thought reevaluation|OTHER: Thought reevaluation + Mood induction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypothalamic-pituitary Dysfunction in Diabetes
Status: COMPLETED
Conditions: Diabete Mellitus|Hypogonadism|Hypogonadotropic Hypogonadism|Hypergonadotropic Hypogonadism|Central Hypothyroidism
Interventions: DIAGNOSTIC_TEST: Diagnostic testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Soluble Guanylate Cyclase (sGC) Stimulator IW-1973 in Diabetic Nephropathy / Diabetic Kidney Disease as Measured by Albuminuria
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus With Diabetic Nephropathy
Interventions: DRUG: IW-1973|DRUG: IW-1973|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extension to Study on Efficacy and Safety of Linzagolix for the Treatment of Endometriosis-associated Pain (EDELWEISS 6)
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: 75 mg linzagolix tablet|DRUG: 200 mg linzagolix tablet|DRUG: Placebo tablet to match 75 mg linzagolix tablet|DRUG: Placebo tablet to match 200 mg linzagolix tablet|DRUG: Add-back capsule (E2 1 mg / NETA 0.5 mg)|DRUG: Placebo capsule to match Add-back capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cell Therapy With Treg Cells Obtained From Thymic Tissue (thyTreg) to Prevent Rejection in Heart Transplant Children
Status: RECRUITING
Conditions: Heart Transplantation
Interventions: BIOLOGICAL: Autologous thyTreg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: In Vitro Analysis of Effluent Dialysate Solution From Patients on Peritoneal Dialysis, With the CloudCath Device
Status: SUSPENDED
Conditions: Peritoneal Dialysis-associated Peritonitis|End Stage Renal Disease
Interventions: DIAGNOSTIC_TEST: Effluent dialysate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Guided Digital Self-Hypnosis Solution for Managing Hot Flashes in Patients Undergoing Anti-Aromatase Hormone Therapy
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer Female
Interventions: OTHER: self-hypnosis sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Advancing Understanding of Transportation Options
Status: COMPLETED
Conditions: Diabetic Retinopathy|Macular Degeneration|Glaucoma|Retinitis Pigmentosa|Vision Disorders|Acute Coronary Syndrome|Implantable Defibrillator User|Congestive Heart Failure|Hypertrophic Obstructive Cardiomyopathy|Orthostatic Hypotension|Syncope|Presyncope|Narcolepsy|Dementia|Multiple Sclerosis|Parkinson Disease|Brain Injuries|Spinal Cord Injuries|Stroke|Vertigo|Dizziness|Seizures|Substance Use|Insulin Dependent Diabetes Mellitus|Arthritis|Foot--Abnormalities|Chronic Obstructive Pulmonary Disease|Obstructive Sleep Apnea|End Stage Renal Disease|Sleep Apnea|Insomnia|Restless Legs Syndrome
Interventions: BEHAVIORAL: Driving Decision Aid|BEHAVIORAL: Older Drivers Website
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase I Trial of Intranasal Peptide T: Safety, Toxicity, and Pharmacokinetics in Human Immunodeficiency Virus-1 (HIV-1) Infected Patients.
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Peptide T
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Methods of Bowel Preparation for Colonoscopy in Hospitalized Patients
Status: COMPLETED
Conditions: Bowel Preparation for Colonoscopy
Interventions: OTHER: Split-dose polyethylene glycol|OTHER: Morning-only polyethylene glycol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Additional Anti-emetic Effect of Ramosetron Prophylaxis After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Ramosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PROFRUVE Program to Promote Fruit and Vegetables Intake Among Children.
Status: COMPLETED
Conditions: Eating Behavior|Healthy Diet|Fruit and Vegetable Intake|Childhood Obesity
Interventions: BEHAVIORAL: Program based on the theory of planned behaviour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Dressing Wear Time After Reduction Mammaplasty
Status: COMPLETED
Conditions: Surgical Site Infection|Skin Colonization
Interventions: PROCEDURE: reduction mammaplasty|PROCEDURE: reduction mammaplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Auditory Hallucinations in Schizophrenia With Bilateral Theta Burst Stimulation
Status: COMPLETED
Conditions: Auditory Hallucinations|Schizophrenia
Interventions: DEVICE: MagPro Cool-B65A/P, Magventure|DEVICE: MagPro Cool-B65A/P, Magventure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HIPEC Using High Intra-abdominal Pressure
Status: COMPLETED
Conditions: Pseudomyxoma Peritonei|Colorectal Cancer
Interventions: PROCEDURE: Cytoreductive surgery|OTHER: Low Intra abdominal pressure HIPEC|OTHER: High Intra abdominal pressure HIPEC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Pre-Emptive Administration Of Ketamine for Controlling Post-thoracotomy Pain
Status: COMPLETED
Conditions: Post Thoracotomy Pain
Interventions: DRUG: Ketamine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Detemir and Sitagliptin on Blood Glucose Control in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir|DRUG: sitagliptin|DRUG: metformin|DRUG: sulphonylurea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Citalopram on Reflux Episodes in Healthy Volunteers
Status: COMPLETED
Conditions: Gastro Esophageal Reflux
Interventions: DRUG: Citalopram HCl|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DYmista NAsal Spray in CHInese Patients
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Azelastine Hydrochl./Fluticasone Prop. 0.137/0.05 MG/ACTUAT|DRUG: Azelastine Hydrochloride 0.137 MG/ACTUAT|DRUG: Fluticasone Propionate 0.05 MG/ACTUAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective, Multi Centric, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of KSM-66 Ashwagandha (Withania Somnifera) in Adults Experiencing High Stress and/or Anxiety
Status: ACTIVE_NOT_RECRUITING
Conditions: Anxiety|Stress
Interventions: DIETARY_SUPPLEMENT: KMS-66 Ashwagandha 300mg|DIETARY_SUPPLEMENT: placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cells Transplantation for Refractory Systemic Lupus Erythematosus (SLE)
Status: UNKNOWN
Conditions: Refractory Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: Allogeneic MSC (AlloMSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Tonabersat for DME
Status: RECRUITING
Conditions: Diabetic Macular Edema
Interventions: DRUG: Tonabersat|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Intravenous Lidocaine on ED50, ED95 and NTI Values of Propofol Induced Unconsciousness
Status: NOT_YET_RECRUITING
Conditions: General Anesthesia
Interventions: DRUG: Lidocaine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment Algorithm for Nausea and Vomiting in the Palliative Phase
Status: UNKNOWN
Conditions: Nausea|Vomiting|Cancer
Interventions: DRUG: metoclopramide|DRUG: granisetron|DRUG: Dexamethasone|DRUG: Granisetron 2Mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bacteremia From Periodontal Treatment to Elucidate the Underpinnings of Sepsis
Status: RECRUITING
Conditions: Bacteremia|Periodontal Diseases|Sepsis|Heart Diseases
Interventions: PROCEDURE: Non-surgical periodontal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quality Control of CE-Certified Phonak Hearing Aids - Sonova2018_05
Status: COMPLETED
Conditions: Hearing Loss, Sensorineural
Interventions: DEVICE: Phonak Audéo B90-Direct|DEVICE: HearingAid_A|DEVICE: HearingAid_B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of GH001 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: 5 Methoxy N,N Dimethyltryptamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Clinical Performance and Usability of iStatis COVID-19 Ag Rapid Test at POC
Status: COMPLETED
Conditions: COVID-19 Virus Infection|COVID-19|Coronavirus Disease-19|COVID-19 Pandemic|SARS-CoV-2 Infection
Interventions: DIAGNOSTIC_TEST: iStatis COVID-19 Ag Rapid Test|DIAGNOSTIC_TEST: "COVID-19 RT-PCR Test EUA Number: EUA200011, Company: Laboratory Corporation of America ("Labcorp")
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Executive Control Training for Adolescents With ADHD: A Randomized Controlled Effectiveness Trial
Status: RECRUITING
Conditions: Attention Deficit Hyperactivity Disorder|Executive Dysfunction
Interventions: BEHAVIORAL: Goal Management training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Complementary Vaccination With Dendritic Cells Pulsed With Autologous Tumor Lysate in Resected Stage III and IV Melanoma Patients.
Status: TERMINATED
Conditions: Malignant Melanoma|Adjuvant Drug Therapy|Vaccin Therapy
Interventions: BIOLOGICAL: Autologous Dendritic Cell vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contrast-enhanced MRI in Children 2 Months to <2 Years
Status: COMPLETED
Conditions: Magnetic Resonance Imaging
Interventions: DRUG: Gadopentetate dimeglumine (Magnevist, BAY86-6661)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Topiramate in Treating Cocaine Dependent Individuals - 1
Status: UNKNOWN
Conditions: Cocaine-Related Disorders
Interventions: DRUG: Topiramate + Cognitive Behavioral Therapy|DRUG: Placebo + Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Immunosuppression Adjustment on COVID-19 Vaccination Response in Kidney Transplant Recipients
Status: RECRUITING
Conditions: COVID-19|Immunosuppression|Vaccine Response Impaired
Interventions: DRUG: Reduction in antimetabolite immunosuppression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Impact of Positive, Neutral and Negative Expectation Speech on Manipulative Therapy Effects
Status: NOT_YET_RECRUITING
Conditions: Chronic Low-back Pain
Interventions: OTHER: Positive expectation speech regarding spinal manipulative therapy|OTHER: Neutral expectation speech regarding spinal manipulative therapy|OTHER: Negative expectation speech regarding spinal manipulative therapy|PROCEDURE: Spinal Manipulative Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Nature and Forest Therapy in Patients With Metabolic Syndrome and Cardiovascular Risk Factors
Status: RECRUITING
Conditions: Metabolic Syndrome, Protection Against
Interventions: BEHAVIORAL: Forest Therapy (Düppeler Forst - Berlin-Wannsee)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Perioperative Coagulopathy With Thromboelastometry (ROTEM) in Liver Transplant
Status: UNKNOWN
Conditions: Blood Coagulation Disorders|Evidence of Liver Transplantation|Liver Cirrhosis
Interventions: PROCEDURE: Thromboelastometry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemoradiotherapy and Consolidation Chemotherapy for Rectal Cancer: A Randomized Controlled Trial
Status: RECRUITING
Conditions: Rectal Neoplasms
Interventions: RADIATION: Neoadjuvant Chemoradiotherapy|DRUG: Adjuvant Chemotherapy|DRUG: Consolidation Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Fixed-dose Combinations and Coadministered Individual Tablets of Saxagliptin/Metformin-Brazil
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Saxagliptin/metformin fixed-dose combination (FDC)|DRUG: Saxagliptin|DRUG: Metformin extended-release (XR)|DRUG: Saxagliptin/Metformin FDC|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Trial Comparing the Safety and Efficacy of Semaglutide Once Weekly Versus Sitagliptin Once Daily in Japanese Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: semaglutide|DRUG: semaglutide|DRUG: sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploring the Impact of Perioperative Galacto-Oligosaccharides (GOS) on Stress, Anxiety and Cognition
Status: WITHDRAWN
Conditions: Anxiety|Pain|Surgery
Interventions: DRUG: Galacto-Oligosaccharide|DRUG: Maltodextrin (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: IMM2902, a HER2/SIRPα Bispecific mAb-Trap Antibody-receptor Fusion Protein, in Patients With HER2-expressing Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Advanced Breast Cancer|Advanced Gastric Cancer
Interventions: DRUG: IMM2902
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT