pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Humeral Head Implants: Radiological and Clinical Evaluation
Status: ACTIVE_NOT_RECRUITING
Conditions: Idiopathic Osteoarthritis|Posttraumatic Osteoarthritis|Humeral Head Necrosis|Instability Arthritis
Interventions: PROCEDURE: Total shoulder arthroplasty (TSA)|PROCEDURE: Hemi shoulder arthroplasty (HSA)|DEVICE: Eclipse™ (Arthrex Inc., Naples, FL, USA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab as Adjunct Treatment in Prevention of Vaso-Occlusive Episodes (VOE) in Sickle Cell Disease (SCD)
Status: RECRUITING
Conditions: Sickle Cell Disease
Interventions: DRUG: Crovalimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of DWP14012 in Patients With Erosive Gastroesophageal Reflux Disease (Phase 2, Therapeutic Exploratory Study)
Status: COMPLETED
Conditions: Erosive Gastroesophageal Reflux Disease
Interventions: DRUG: DWP14012|DRUG: Esomeprazole|DRUG: DWP14012 placebo|DRUG: Esomeprazole placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screening for Colorectal Cancer With FOBT, Virtual Colonoscopy and Optical Colonoscopy. A Randomized Clinical Trial in the Florence District
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: OTHER: Invitation to screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Treating Alcohol Use In Older Adults With Depression
Status: COMPLETED
Conditions: Alcoholism|Depression
Interventions: DRUG: NALTREXONE|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HIIT + RT on Body Composition and Gut Microbiota in Postmenopausal Women (PACWOMan)
Status: COMPLETED
Conditions: Overweight|Postmenopausal Women
Interventions: OTHER: Training program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Blood Glucose Response of Novel Wild Rice Enhanced Food Products (Trial 2)
Status: NOT_YET_RECRUITING
Conditions: Blood Glucose
Interventions: OTHER: Kellogg's - rice krispies (control)|OTHER: Kellogg's - rice krispies (control) + 125ml milk|OTHER: Novel cereal (40% Canadian wild rice, 60% fava bean blend) + 125 ml milk|OTHER: Novel cereal (40% Canadian wild rice, 60% fava bean blend)|OTHER: Novel cereal (40% Canadian wild rice, 50% fava bean blend) + 10% purple powder (sweet potato)|OTHER: Novel cereal (40% Canadian wild rice, 50% fava bean blend) + 10% purple powder (sweet potato) + 125 ml milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: BPO vs Hibiclens Soap for Surgical Preparation
Status: COMPLETED
Conditions: Propionibacterium Acnes
Interventions: DRUG: Benzoyl Peroxide 10% Bar|DRUG: Chlorhexidine Gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study to Evaluate the Efficacy and Safety of Aliskiren Alone and in Combination With Hydrochlorothiazide in Patients With Essential Hypertension.
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: aliskiren
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Cilostazol in Ischemic Stroke Patients With Peripheral Arterial Disease (SPAD Study)
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: Cilostazol|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the New Candidate Rift Valley Fever Virus Vaccine in Healthy Adults
Status: COMPLETED
Conditions: RVF|Rift Valley Fever
Interventions: BIOLOGICAL: ChAdOx1 RVF|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Limb Size of Transverse Coloplasty Pouch
Status: UNKNOWN
Conditions: Colon Cancer
Interventions: PROCEDURE: Transverse coloplasty pouch (Long limb)|PROCEDURE: Transverse coloplasty pouch (Short limb)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Impact of the Routine Aminophylline Administration Following Regadenoson Stress on SPECT Myocardial Perfusion
Status: WITHDRAWN
Conditions: Coronary Artery Disease
Interventions: DRUG: ASSUAGE Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Verification Study on Lafutidine in Mild Reflux Oesophagitis - Double Blind Controlled Study With Famotidine -
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: Lafutidine|DRUG: Famotidine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Effects of Non-nutritive Sweeteners
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Sucralose|OTHER: Water|DIETARY_SUPPLEMENT: glucose load
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: ENGAGE - Meeting Mental Health Needs of Complex Comorbid Patients
Status: UNKNOWN
Conditions: Comorbidity|Substance Abuse|Personality Disorder
Interventions: BEHAVIORAL: Cognitive behavioural therapy|OTHER: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dopaminergic Enhancement of Learning and Memory in Healthy Adults and Patients With Dementia/Mild Cognitive Impairment
Status: UNKNOWN
Conditions: Alzheimer's Disease|Mild Cognitive Impairment|Healthy
Interventions: DRUG: Levodopa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Fortified Cheese and Well-being in the Institutionalized Elderly
Status: UNKNOWN
Conditions: The Focus is to Assess 25-hydroxyvitamin D Levels and Well-being
Interventions: DIETARY_SUPPLEMENT: High dose|DIETARY_SUPPLEMENT: Reference dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Optimal Human Dose for GII.2 Norovirus (Snow Mountain) Challenge Studies
Status: COMPLETED
Conditions: Gastroenteritis Norovirus
Interventions: BIOLOGICAL: Norovirus GII.2 Challenge|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Acceptability of Less Harmful Alternatives to Cigarettes
Status: COMPLETED
Conditions: Bladder Cancer|Cervical Cancer|Esophageal Cancer|Gastric Cancer|Head and Neck Cancer|Kidney Cancer|Leukemia|Liver Cancer|Lung Cancer|Pancreatic Cancer|Tobacco Use Disorder
Interventions: BEHAVIORAL: telephone-based intervention|DRUG: nicotine replacement therapy|OTHER: informational intervention|OTHER: internet-based intervention|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Phase I Clinical Study, Randomized, Single-blind, Placebo-controlled, Multiple Doses, Dose Escalation Study of the Safety, Tolerability and Pharmacokinetics of Donepezil Patch in Healthy Male Subjects.
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Donepezil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Test the Efficacy and Safety of CSL312 on Catheter-associated Blood Clot Formation in Subjects With Cancer Who Receive Chemotherapy Through a PICC Line
Status: WITHDRAWN
Conditions: PICC-associated Thrombosis
Interventions: DRUG: CSL312|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: EnCoRe MoMS: Engaging Communities to Reduce Morbidity From Maternal Sepsis
Status: ENROLLING_BY_INVITATION
Conditions: Maternal Sepsis|Infections
Interventions: BEHAVIORAL: Maternal Sepsis Safety Bundle
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Simultaneous Physiotherapy and Orthopedic Surgeon Interdisciplinary Care (SPOSIC)
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis, Knee|Arthritis
Interventions: BEHAVIORAL: Receives interdisciplinary sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Polyphenols on Endothelial Function in Obstructive Sleep Apnea
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea
Interventions: DIETARY_SUPPLEMENT: one month polyphenols supplementation (600mg)|DIETARY_SUPPLEMENT: placebo (microcrystalline cellulose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: FDA Approved Medication to Reduce Binge Eating and/or Purging
Status: COMPLETED
Conditions: Binge Eating Disorder|Bulimia Nervosa
Interventions: DRUG: Phentermine/Topiramate-First|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HAL-RAR Technique for Treating Hemorrhoids
Status: COMPLETED
Conditions: Hemorrhoidal Disease
Interventions: PROCEDURE: Hemorrhoidal Arterial Ligation (HAL) and Recto Anal Repair (RAR)|PROCEDURE: Excision of thrombosed hemorrhoid / Hemorrhoidectomy /
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Changes in Cigarette Consumption During a Switch to Very Low Nicotine Cigarettes
Status: COMPLETED
Conditions: Tobacco Use
Interventions: OTHER: Non-Menthol Very Low Nicotine Cigarettes|OTHER: Menthol Very Low Nicotine Cigarettes|OTHER: Subject's UB non-mentholated filtered cigarettes|OTHER: Subject's UB mentholated filtered cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: BI 1356 BS in Japanese Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Low dose of BI 1356 BS|DRUG: Medium dose of BI 1356 BS|DRUG: High dose of BI 1356 BS|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ-56136379 in Healthy Participants
Status: WITHDRAWN
Conditions: Healthy
Interventions: DRUG: JNJ-56136379|DRUG: Bictegravir (BIC) plus Emtricitabine (FTC) plus Tenofovir Alafenamide (TAF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of SHR2150 (TLR7 Agonist) in Combination With Chemotherapy Plus PD-1 or CD47 Antibody in Subjects With Unresectable/ Metastatic Solid Tumors
Status: UNKNOWN
Conditions: Solid Tumor
Interventions: DRUG: SHR2150|DRUG: Anti-Cancer Agent|DRUG: SHR2150
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Myofascial Release Therapy on Dysphagia in Post-stroke Patients
Status: NOT_YET_RECRUITING
Conditions: Dysphagia
Interventions: BEHAVIORAL: Rehabilitation treatment|BEHAVIORAL: Myofascial Release Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Atraumatic Bone Marrow Edema With Denosumab and Teriparatide vs Placebo
Status: SUSPENDED
Conditions: Bone Marrow Oedema Syndrome|High Turnover Bone Disease|Quality of Life
Interventions: DRUG: Denosumab|DRUG: Teriparatide|DRUG: Placebo Denosumab|DRUG: Placebo Teriparatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vorinostat and Bortezomib in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma
Interventions: DRUG: bortezomib|DRUG: vorinostat|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I of Carboplatin-Olaparib Followed by Olaparib Monotherapy in Advanced Cancer
Status: COMPLETED
Conditions: Breast Cancer|Ovarian Cancer|Advanced Cancer
Interventions: DRUG: carboplatin, olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Asymmetric Rapid Maxillary Expansion on Dentoskeletal Structures in Mixed Dentition
Status: COMPLETED
Conditions: Maxillary Anomaly|Asymmetric Maxillary Arch (Disorder)|Cross Bite
Interventions: DEVICE: A locked modified acrylic bonded rapid maxillary expansion appliance (ARME)|DEVICE: A locked modified acrylic bonded rapid maxillary expansion appliance (ARME)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eosinophilic Esophagitis: Influence of Dilation on Dysphagia and Inflammation
Status: COMPLETED
Conditions: Eosinophilic Esophagitis|Esophageal Stenosis|Esophageal Dilation|Esophageal Dilatation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Gain-framed Messages and NRT for Lung Cancer Screening Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer Screening|Smoking Cessation
Interventions: COMBINATION_PRODUCT: Gain-framed messaging plus NRT|BEHAVIORAL: Unframed messaging materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post Market Surveillance of the HeartMate 3 Left Ventricular Assist System in Korea
Status: COMPLETED
Conditions: Advanced Heart Failure
Interventions: DEVICE: HeartMate 3™ left ventricular assist system (HM3 LVAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-56022473 in Subjects With Systemic Lupus Erythematosus
Status: WITHDRAWN
Conditions: Lupus Erythematosus, Systemic
Interventions: DRUG: JNJ-56022473|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nausea in Patients Receiving Hydromorphone vs Oxycodone After Total Hip Replacement Surgery
Status: COMPLETED
Conditions: Nausea
Interventions: DRUG: Oxycodone|DRUG: Hydromorphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Local Injection of Pain Medication to Reduce Pain After Bone Marrow Procedures in Pediatric Neuroblastoma Patients
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: DEVICE: propofol|DRUG: ropivacaine|BEHAVIORAL: Wong-Baker FACES® Pain Rating Scale|BEHAVIORAL: Post-procedural quality of life (QOL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Immunogenicity of AGS-v PLUS, a Universal Mosquito-Borne Disease and Mosquito Control Vaccine
Status: COMPLETED
Conditions: Mosquito-Borne Infectious Diseases
Interventions: BIOLOGICAL: AGS-v PLUS Vaccine|BIOLOGICAL: Montanide ISA-51 Adjuvant|BIOLOGICAL: Alhydrogel® Adjuvant|BIOLOGICAL: Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Advantage of Detection of phIGFBP-1 to Reduce Hospitalization Time for Stable Patients With a Risk of Preterm Labour.
Status: COMPLETED
Conditions: Patients With a Risk of Preterm Labour
Interventions: DEVICE: Actim Partus® test|OTHER: usual procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of a New Patient Warming System Using a Polymer Conductive Warming Under-body and Upper-body Blanket With Forced Air Warming
Status: COMPLETED
Conditions: Hypothermia
Interventions: DEVICE: Patient Warming with Forced Air|DEVICE: Resistive Warming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Impact of Epidural Anesthesia in Relation to Age in Pediatric Patients.
Status: UNKNOWN
Conditions: Hemodynamic Monitoring|Anesthesia; Adverse Effect|Pediatric Major Surgery|Epidural Analgesia
Interventions: DRUG: Levobupivacaine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Banxiaxiexin Decoction Combined With Vonoprazan-Amoxicillin Dual Therapy in H.Pylori Eradication
Status: NOT_YET_RECRUITING
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Vonoprazan|DRUG: Amoxicillin|DRUG: Banxiaxiexin decotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nebivolol Versus Losartan Versus Nebivolol+Losartan Against Aortic Root Dilation in Genotyped Marfan Patients
Status: UNKNOWN
Conditions: Marfan Syndrome
Interventions: DRUG: Losartan and nebivolol|DRUG: Losartan|DRUG: Nebivolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Melatonin in Healthy Volunteers
Status: COMPLETED
Conditions: Sepsis
Interventions: DRUG: Melatonin|DRUG: Melatonin|DRUG: Melatonin|DRUG: Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phasix Mesh Use in Complex Open Ventral Hernias Study
Status: WITHDRAWN
Conditions: Ventral Hernia
Interventions: PROCEDURE: Repair of ventral hernia using biologic mesh|PROCEDURE: Repair of ventral hernia using suture repair or synthetic mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Wild Man Programme - a Nature-based Rehabilitation Enhancing Quality of Life for Men on Long-term Sick Leave
Status: UNKNOWN
Conditions: Stress|Anxiety|Depression|Cardiac Disease|Cancer|Diabetes|Copd
Interventions: OTHER: Nature-Body-Mind-Community|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Frozen Section Pathology to Guide Surgical Treatment for Lung Adenocarcinoma (ECTOP-1016)
Status: RECRUITING
Conditions: Lung Adenocarcinoma|Surgical Procedure, Unspecified|Pathology
Interventions: PROCEDURE: Surgical resection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized Controlled Trial to Investigate The Role of Adjuvant Inhalable Sodium Bicarbonate Solution 8.4% in Treatment of COVID-19
Status: UNKNOWN
Conditions: COVID-19 Pneumonia|Covid19|COVID-19 Acute Respiratory Distress Syndrome
Interventions: DRUG: Sodium Bicarbonate Solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial
Status: COMPLETED
Conditions: Heart Rate|Heart Rate Variability|Inflammation
Interventions: DRUG: methyl donor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Tackling Intrusive Traumatic Memories After a Difficult Birth
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder|Intrusive Traumatic Memories
Interventions: BEHAVIORAL: Brief behavioural procedure including a computerized visuospatial task (computer game "Tetris")
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Study of Postmenopausal Women With ER and /or PgR Positive Breast Cancer Treated With Letrozole
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers of Prednisolone Treatment (P05888)
Status: COMPLETED
Conditions: Insulin Resistance|Hyperglycemia|Glucose Intolerance
Interventions: DRUG: Placebo|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tunneled Pleural Catheters for Refractory Effusions Attributed to Congestive Heart Failure (TREAT-CHF) Trial
Status: WITHDRAWN
Conditions: Pleural Effusions, Chronic|Congestive Heart Failure|Shortness of Breath
Interventions: DEVICE: tunneled pleural catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Nutritional Supplementation on Sleep Quality and Gut Microbiome Composition in Older Adults
Status: COMPLETED
Conditions: Sleep|Gut Microbiome
Interventions: DIETARY_SUPPLEMENT: 5-HTP|OTHER: Without 5-HTP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Double-Blind, Randomized, Dose Response Study of Three Doses of Delavirdine Mesylate (U-90152S) in Combination With Zidovudine (ZDV) Versus ZDV Alone in HIV-1 Infected Individuals With CD4 Counts of 200-500mm3
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Delavirdine mesylate|DRUG: Lamivudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Acalabrutinib in Combination With ACP-319, for Treatment of Chronic Lymphocytic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: acalabrutinib|DRUG: ACP-319
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Clinical Trial Comparing the Safety, Efficacy, and Immunogenicity of Recombinant Anti-interleukin-6 Receptor Humanized Monoclonal Antibody Injection in Combination With Methotrexate and Jamelor ® in the Treatment of Moderate to Severe Rheumatoid Arthritis
Status: COMPLETED
Conditions: Moderate to Severe Active Rheumatoid Arthritis
Interventions: DRUG: HS628+MTX|DRUG: Actemra +MTX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Effects of TM30339 on Weight Loss in Obese Individuals.
Status: TERMINATED
Conditions: Obesity
Interventions: DRUG: TM30339 and/or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect Of A Controlled Daily Skin Care Regimen On Retinoic Acid Tolerance
Status: COMPLETED
Conditions: Sun-Damaged Skin|Retinoid Intolerance
Interventions: DRUG: Tazorac|DRUG: Dove Mild Cleanser|DRUG: Dove Facial Moisturizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intervention Through EMDR and CBT With Women Victim of Childhood Sexual Abuse. A Randomized Controlled Trial.
Status: UNKNOWN
Conditions: Posttraumatic Stress Disorder|Somatization|Obsessive-Compulsive Disorder|Depression|Anxiety|Hostility|Dissociative Disorder
Interventions: BEHAVIORAL: TRAUMA CENTERED EMDR-BASED TREATMENT and TRAUMA-FOCUSED CBT-BASED TREATMENT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of EP262 in Subjects With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Oral EP262|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of STP206 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: STP206 or vehicle control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Open-label Study of Tofacitinib for Moderate to Severe Skin Involvement in Young Adults With Lupus
Status: COMPLETED
Conditions: Cutaneous Lupus|Systemic Lupus Erythematosus
Interventions: DRUG: Tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Treatments for a Type of Kidney Cancer Called TFE/Translocation Renal Cell Carcinoma (tRCC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Renal Cell Carcinoma|Stage III Renal Cell Cancer AJCC v8|Stage IV Renal Cell Cancer AJCC v8|TFE3-Rearranged Renal Cell Carcinoma|Unresectable Renal Cell Carcinoma
Interventions: DRUG: Axitinib|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tabalumab (LY2127399) in Participants With Previously Treated Multiple Myeloma (MM)
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Placebo|DRUG: Dexamethasone|DRUG: Bortezomib|BIOLOGICAL: Tabalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Basal Insulin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Lixisenatide (AVE0010)|DRUG: Placebo|DRUG: Basal Insulin|DRUG: Metformin|DEVICE: Pen auto-injector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compare Pharmacokinetics and Safety of JP-1366 Between Korean and Caucasian
Status: COMPLETED
Conditions: Anti-Ulcer Agents
Interventions: DRUG: coadministration of JP-1366 and aceclofenac|DRUG: coadministration of JP-1366 and meloxicam|DRUG: coadministration of JP-1366 and naproxen|DRUG: single-dosing of JP-1366 in Korean and Caucasian
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caffeinated Gum to Prevent Post-Operative Ileus: A Prospective, Randomized, Placebo-controlled Trial
Status: WITHDRAWN
Conditions: C.Surgical Procedure; Digestive System
Interventions: DIETARY_SUPPLEMENT: Caffeine|OTHER: Gum|BEHAVIORAL: wear silicone bracelet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pilot Trial of Antibiotics Versus Surgery for Treating Acute Appendicitis
Status: COMPLETED
Conditions: Acute Uncomplicated Appendicitis
Interventions: DRUG: 1 gm IV ertapenem at enrollment|DRUG: 1 gm IV ertapenem at Day 2 and oral metronidazole and cefdinir to complete 10 days|PROCEDURE: Appendectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the "Start to Move" Protocol on Functionality, Delirium and Acquired Weakness in ICU
Status: COMPLETED
Conditions: Intensive Care Unit Acquired Weakness|Intensive Care Unit Delirium|Intensive Care Neuropathy|Intensive Care Unit Syndrome|Mechanical Ventilation Complication
Interventions: OTHER: Star to move Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The ANCA Vasculitis Questionnaire (AAV-PRO©)
Status: COMPLETED
Conditions: Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) (EGPA)|Churg-Strauss Syndrome (CSS)|Granulomatosis With Polyangiitis (Wegener's) (GPA)|Wegener Granulomatosis (WG)|Microscopic Polyangiitis (MPA)|ANCA-Associated Vasculitis (AAV)|Vasculitis
Interventions: OTHER: Online questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Self-Advocacy for Independent Life (SAIL) After TBI
Status: COMPLETED
Conditions: TBI (Traumatic Brain Injury)
Interventions: BEHAVIORAL: Self-Advocacy for Independent Life (SAIL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Immunogenicity and Safety of Enterovirus Type 71 Vaccine,Inactivated(Vero Cells) in Volunteers Aged From 6 to 71 Months
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: Enterovirus Type 71 Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of iPRF Injections in Temporomandibular Joints Degeneration Management
Status: ENROLLING_BY_INVITATION
Conditions: Temporomandibular Disorder|Temporomandibular Joint Disorders|Temporomandibular Arthritis|Temporomandibular Joint Osteoarthritis
Interventions: BIOLOGICAL: Injectable platelet-rich fibrin|BIOLOGICAL: Platelet-rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can High-flow Nasal Oxygenation Improve Oxygen Saturation During Analgo-sedation in Obese Adults?
Status: UNKNOWN
Conditions: Noninvasive Ventilation|Respiratory Insufficiency|Obesity|Deep Sedation|Hypoxia|Airway Management|Colonoscopy
Interventions: DEVICE: high-flow nasal oxygenation (HFNO)|DEVICE: low-flow nasal oxygenation (LFNO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception
Status: RECRUITING
Conditions: Histamine|Cowhage
Interventions: OTHER: Histamine|OTHER: Cowhage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Condition Vasoregulation Function Endothelium in Patients With CML Getting TKI II Generation Bosutinib
Status: RECRUITING
Conditions: Chronic Myeloid Leukaemia
Interventions: DIAGNOSTIC_TEST: taking blood for the study of biochemical parameters and the study of microcirculation using the method of laser Doppler flowmetry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Application of 3D Printing in Laparoscopic Surgery of Liver Tumors
Status: UNKNOWN
Conditions: Liver Cancer|Hepatocellular Carcinoma|Liver Metastases
Interventions: PROCEDURE: Laparoscopic liver resection|DEVICE: 3D printing model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Trigeminal Nerve Block for Typical or Atypical Facial Pain
Status: COMPLETED
Conditions: Typical Facial Pain|Atypical Facial Pain
Interventions: DRUG: Bupivacaine|DRUG: Triamcinolone|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Heart Rate Variability (HRV) in Patients With Neurogenic Detrusor Overactivity (NDO) Before and After Botulinum Neurotoxin Type A (BoNT/A) Intradetrusor Injections
Status: COMPLETED
Conditions: Bladder Disorder, Neurogenic
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Age-related Macular Degeneration by Fetal Retinal Pigment Epithelial Cells Transplantation
Status: UNKNOWN
Conditions: Age Related Macular Degeneration|Macular Degeneration|AMD
Interventions: DRUG: fRPE cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of tDCS of the Motor Cortex on Chemotherapy Induced Nausia and Vomiting
Status: UNKNOWN
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: DEVICE: tDCS|DEVICE: sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study of Tumor Polypeptide DC-CTL in the Treatment of Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Solid Tumor
Interventions: BIOLOGICAL: Tumor polypeptide pool induced DC-CTL cell injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plasmalyte Versus Saline in Trauma Patients
Status: TERMINATED
Conditions: Severe Trauma Patients|Acute Kidney Injury
Interventions: DRUG: Plasmalyte Viaflo|DRUG: NaCl 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Lebrikizumab (LY3650150) in Participants With Moderate-to-Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: Lebrikizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reflexology or Aromatherapy Massage in Relieving Symptoms in Patients With Cancer
Status: COMPLETED
Conditions: Pain|Psychosocial Effects of Cancer and Its Treatment|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: OTHER: questionnaire administration|PROCEDURE: aromatherapy and essential oils|PROCEDURE: management of therapy complications|PROCEDURE: massage therapy|PROCEDURE: psychosocial assessment and care|PROCEDURE: reflexology procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Prospective Randomized Multicenter Trial of the Guidewire for Echo-guided Interventions
Status: UNKNOWN
Conditions: Atrial Septal Defect
Interventions: DEVICE: Guidewire for echo-guided interventions|DEVICE: Cook lunderquist guidewire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Analyses of Metabolic Agents Following Brain Radiation
Status: NOT_YET_RECRUITING
Conditions: Malignant Central Nervous System Neoplasm
Interventions: DRUG: Anhydrous Enol-oxaloacetate|OTHER: Best Practice|PROCEDURE: Biospecimen Collection|PROCEDURE: Magnetic Resonance Spectroscopic Imaging|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: InterStim Basic Evaluation Lead Post-Market Clinical Follow-up Study
Status: COMPLETED
Conditions: Overactive Bladder|Urinary Urge Incontinence|Urgency-frequency Syndrome
Interventions: DEVICE: InterStim Basic Evaluation lead and foramen needle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D and Denosumab on Bone Remodelling in Women With Postmenopausal Osteoporosis
Status: COMPLETED
Conditions: Hypovitaminosis D|Osteoporosis, Postmenopausal|Menopause
Interventions: DRUG: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BG & TMZ Therapy of Glioblastoma Multiforme
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: BIOLOGICAL: MGMTP140K-encoding retroviral vector|DRUG: O6-benzylguanine|DRUG: temozolomide|OTHER: laboratory biomarker analysis|PROCEDURE: autologous hematopoietic stem cell transplantation|PROCEDURE: in vitro-treated peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Lorazepam, Clonazepam and Clonazepam + Fosphenytoin for the Treatment of Out-of-hospital Generalized Status Epilepticus
Status: COMPLETED
Conditions: Status Epilepticus|Epilepsy
Interventions: DRUG: Clonazepam|DRUG: Fosphenytoin|DRUG: Placebo|DRUG: Lorazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Austrian CoronaVirus Adaptive Clinical Trial (COVID-19)
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Chloroquine or Hydroxychloroquine|DRUG: Lopinavir/Ritonavir|OTHER: Best standard of care|DRUG: Rivaroxaban|DRUG: Thromboprophylaxis|DRUG: Candesartan|DRUG: non-RAS blocking antihypertensives|DRUG: Remdesivir|DRUG: Asunercept 400mg|DRUG: Asunercept 100mg|DRUG: Asunercept 25mg|DRUG: Pentaglobin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative RCT of Brief Internet-based Compassionate Mind Training and Cognitive-behavioral Therapy for Mothers and Their Babies
Status: COMPLETED
Conditions: Comparison of Internet-based CBT and CMT
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Compassionate Mind Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Gut Microbiota-Mediated Inflammatory Interactions Between AUD and HIV Infection
Status: RECRUITING
Conditions: Alcohol Use Disorder|Human Immunodeficiency Virus
Interventions: DIETARY_SUPPLEMENT: 10 day prebiotic consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Complementary Acupuncture Treatment of Dysphagia in Stroke
Status: RECRUITING
Conditions: Stroke
Interventions: OTHER: Verum acupuncture group|OTHER: Sham control group I|OTHER: Sham control group II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Determine the Food Effect and Bioavailability of Three Formulations of Veliparib in Subjects With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: veliparib|DRUG: veliparib|DRUG: veliparib|DRUG: veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Outpatient Symptom Management on Gynecologic Oncology Patients Receiving Chemotherapy
Status: COMPLETED
Conditions: Uterine Cervical Neoplasms|Ovarian Neoplasms|Gynecologic Neoplasms|Fallopian Tube Neoplasms|Vulvar Neoplasms|Vaginal Neoplasms|Peritoneal Neoplasms
Interventions: BEHAVIORAL: Specialized Symptom Management and Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tailoring of Vaccine-Focused Messages: Disease Salience
Status: COMPLETED
Conditions: Human Papillomavirus
Interventions: BEHAVIORAL: Baseline Survey|BEHAVIORAL: Current CDC Message|BEHAVIORAL: Cervical Cancer Message|BEHAVIORAL: Control Message|BEHAVIORAL: Post-Intervention Survey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Improving Sleep and Psychological Functioning in People With Depression and Insomnia
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders|Depression
Interventions: DRUG: Eszopiclone|DRUG: Fluoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of ZYIL1 Following Oral Administration in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ZYIL1 capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adherence and Acceptability to and Blood Levels of Tenofovir Gel and Tablets in HIV Uninfected Women
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Tenofovir disoproxil fumarate|DRUG: Tenofovir gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Anakinra to Prevent Post-infarction Remodeling
Status: COMPLETED
Conditions: ST Segment Elevation Acute Myocardial Infarction
Interventions: DRUG: Anakinra|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rivaroxaban Anticoagulation for Superficial Vein Thrombosis
Status: COMPLETED
Conditions: Symptomatic Superficial Vein Thrombosis
Interventions: DRUG: Rivaroxaban|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Altitude (HA) Residents With Pulmonary Vascular Diseseases (PVD), Pulmonary Artery Pressure (PAP) Assessed at HA (2840m) vs Sea Level (LA)
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Vascular Disease|Pulmonary Arterial Hypertension|Chronic Thromboembolic Pulmonary Hypertension
Interventions: BEHAVIORAL: Relocation from HA to LA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Changes of Skin Resistance After Midazolam and After the End of Anaesthesia
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Peg-Intron for Prevention of Disease Progress in Chronic Hepatitis C Patients With Cirrhosis (Study P02569)
Status: COMPLETED
Conditions: Chronic Hepatitis C|Cirrhosis
Interventions: BIOLOGICAL: peginterferon alfa-2b (SCH 54031)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tightrope or Screw Fixation of Acute Tibiofibular Syndesmotic Injury
Status: COMPLETED
Conditions: Syndesmotic Injury of the Ankle
Interventions: DEVICE: Tightrope Syndesmosis Repair Kit|DEVICE: Syndesmotic screw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ThoHSpEkt Thoracoscopic Ectomy of Radioactively Marked Pulmonary Nodules With Free-hand SPECT
Status: TERMINATED
Conditions: Solitary Pulmonary Nodule|Bronchial Neoplasms
Interventions: DRUG: Radioactive labelling of pulmonary nodules|DEVICE: CT guided radioactive labelling|DEVICE: Electromagnetic guided bronchoscopic radioactive labelling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Preference on the Feedback Mechanisms of Dose Delivery Confirmation With the Breezhaler® Device Compared to the Ellipta® Device in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive (COPD)
Interventions: OTHER: Patient preference questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER