pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Evaluate the Efficacy and Safety of MEDI0382 in the Treatment of Overweight and Obese Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: MEDI0382 low dose|DRUG: MEDI0382 mid dose|DRUG: MEDI0382 high dose|DRUG: Placebo|DRUG: Liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of LEE011 and Ceritinib in Patients With ALK-positive Non-small Cell Lung Cancer.
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Ribociclib|DRUG: Ceritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Combined Grape Seed Extract and L-citrulline Supplementation on Hemodynamic Responses in Young Males
Status: COMPLETED
Conditions: Dietary Supplementation
Interventions: DIETARY_SUPPLEMENT: Grape seed extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of Buprenorphine HCl Buccal Film in Subjects With Low Back Pain
Status: COMPLETED
Conditions: Pain|Low Back Pain
Interventions: DRUG: Buprenorphine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Clinical Study to Evaluate the Efficacy and Safety of HLX07+HLX10 +mFOLFOX6 or HLX07 Monotherapy in Patients With mCRC
Status: NOT_YET_RECRUITING
Conditions: CRC
Interventions: DRUG: HLX07|DRUG: HLX10|DRUG: mFOLFOX6
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Acetazolamide on Sleep Related Breathing Disturbances in Patients With Respiratory Disease at Altitude
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: ACETAZOLAMIDE oral capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)
Status: RECRUITING
Conditions: Smoking Cessation|Nicotine Addiction|Schizophrenia
Interventions: DEVICE: active F8-coil delivered rTMS|DEVICE: active H-coil delivered rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Teeth Brushing in Ventilated COVID-19 Patients.
Status: COMPLETED
Conditions: Microbial Colonization|COVID-19 Respiratory Infection|Dysbiosis|VAP - Ventilator Associated Pneumonia|HAI
Interventions: PROCEDURE: Oral Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Gemtuzumab Ozogamicin and Cyclosporine in Treating Older Patients With Relapsed Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: cyclosporine|DRUG: gemtuzumab ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Muscle Trainins Inspiratory Linked to Cardiac Rehabilitation Post-operative of CABG Surgery
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DEVICE: IMT - POWERbreathe Plus Light Resistance®, SP, BR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Contraceptive Efficacy, Tolerance and Acceptability of a Benzalkonium Chloride Spermicide Cream In Women Aged Over 40 Years of Age
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Benzalkonium Chloride Spermicide Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Bioequivalence of Mupirocin Calcium Cream, 2% and Bactroban® Cream and Compare Both to a Vehicle in Treatment of Secondarily Infected Traumatic Skin Lesions.
Status: COMPLETED
Conditions: Secondarily Infected Traumatic Skin Lesions
Interventions: DRUG: Mupirocin Calcium Cream, 2%|DRUG: Bactroban® Cream|DRUG: Cream vehicle of test product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The DARE Warfarin CER Study
Status: UNKNOWN
Conditions: Deep Venous Thrombosis|Pulmonary Embolism
Interventions: DRUG: Dabigatran: extended treatment (e.g at least 90 days)|DRUG: Dabigatran: extended treatment (e.g at least 180 days)|DRUG: Dabigatran: extended treatment (e.g at least 270 days)|DRUG: Apixaban: extended treatment (e.g at least 90 days)|DRUG: Apixaban: extended treatment (e.g at least 180 days)|DRUG: Apixaban: extended treatment (e.g at least 270 days)|DRUG: Rivaroxaban: extended treatment (e.g at least 90 days)|DRUG: Rivaroxaban: extended treatment (e.g at least 180 days)|DRUG: Rivaroxaban: extended treatment (e.g at least 270 days)|DRUG: Edoxaban: extended treatment (e.g at least 90 days)|DRUG: Edoxaban: extended treatment (e.g at least 180 days)|DRUG: Edoxaban: extended treatment (e.g at least 270 days)|DRUG: Warfarin: extended treatment (e.g at least 90 days)|DRUG: Warfarin: extended treatment (e.g at least 180 days)|DRUG: Warfarin: extended treatment (e.g at least 270 days)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Image-Guided Radiation Therapy for Bladder-Cancer Patients Undergoing Radiotherapy and Concurrent Gemcitabine Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Bladder Cancer
Interventions: OTHER: external radiation therapy with gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Korean Cancer Study Group: Translational bIomarker Driven UMbrella Project for Head and Neck (TRIUMPH), Esophageal Squamous Cell Carcinoma- Part 1 (HNSCC)]
Status: COMPLETED
Conditions: HNSCC|Head and Neck Neoplasms
Interventions: DRUG: BYL719|DRUG: Poziotinib|DRUG: Nintedanib|DRUG: Abemaciclib|DRUG: Durvalumab,Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ESP Block on Patient Outcomes in Patients With Liver Tumor Undergoing Radiofrequency Ablation
Status: UNKNOWN
Conditions: Hepatic Carcinoma
Interventions: PROCEDURE: Group ESP|OTHER: Non-blocked Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A 24-week Evaluation of GSK573719/Vilanterol (62.5/25mcg) and Components in COPD
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: 62.5/25mcg|DRUG: 62.5mcg|DRUG: 25mcg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving 24-hour Blood Pressure in Obstructive Sleep Apnea
Status: WITHDRAWN
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Continuous Positive Airway Pressure CPAP|DRUG: Telmisartan 80mg|DIETARY_SUPPLEMENT: Alpha-Lipoic Acid 600mg|OTHER: Microcrystalline Cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of 'Functional Range Conditioning' in Treating Patients With Chronic Non-specific Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: BEHAVIORAL: FRC exercise|BEHAVIORAL: Conventional Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Essential Oil Inhalation Patches on Perceived Burn-out & Stress on an Inpatient Medical-surgery Unit.
Status: ENROLLING_BY_INVITATION
Conditions: Nursing Personnel
Interventions: OTHER: Oil Inhalation Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Physical Therapy Intervention on Motor Performance in Bhutanese Preterm Infants
Status: NOT_YET_RECRUITING
Conditions: Infant, Premature
Interventions: OTHER: Supporting play exploration and early developmental intervention(SPEEDI)|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SELF-BREATHE RCT for Chronic Breathlessness
Status: COMPLETED
Conditions: Cancer|COPD|Asthma|Bronchiectasis Adult|Interstitial Lung Disease|Cystic Fibrosis|Chronic Heart Failure|Sickle Cell Disease|Renal Failure|Liver Failure|Post COVID-19|Dyspnea
Interventions: OTHER: SELF-BREATHE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Lavender Essential Oil in Patients With Chronic Heart Failure
Status: NOT_YET_RECRUITING
Conditions: Chronic Heart Failure
Interventions: OTHER: aromatherapy inhalation with lavender essential oil|OTHER: aromatherapy inhalation with coconut essential oil.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Efficacy of rhNGF Eye Drops Solution Versus Vehicle in Patients With Glaucoma
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: rhNGF|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Oral Etoposide Combined With Antirotinib and Envollizumab in Elderly Patients With Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Progression Free Survival(PFS)
Interventions: DRUG: Toposide capsules combined with anrotinib and Emvolizumab group
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of KVA12123 Treatment Alone and in Combination With Pembrolizumab In Advanced Solid Tumors (VISTA-101)
Status: RECRUITING
Conditions: Cancer|Solid Tumor|Melanoma|Carcinoma|Sarcoma|Lung Cancer|Prostate Cancer|Breast Cancer|Colo-rectal Cancer|Uterine Cancer|Pancreatic Cancer|Gastric Cancer|Esophageal Cancer|Thyroid Cancer|Ovarian Cancer|Kidney Cancer|Head and Neck Cancer
Interventions: DRUG: KVA12123 - Dose Escalation|DRUG: KVA12123 Plus Pembrolizumab - Dose Escalation|DRUG: KVA12123 - Dose Expansion|DRUG: KVA12123 Plus Pembrolizumab - Dose Expansion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Doxycycline for the Prevention of Syphilis in Men Who Have Sex With Men (DaDHS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Syphilis|Sexually Transmitted Infections
Interventions: DRUG: Doxycycline|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Menstrual Health Education's Impact on Knowledge, Attitudes and Self Care Behavior of Dysmenorrheal Adolescents
Status: UNKNOWN
Conditions: Primary Dysmenorrhea
Interventions: OTHER: Educational session and Information Pamphlet|OTHER: Information Pamphlet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Design and Implementation of a Nutritional Intervention in Patients With Oropharyngeal Dysphagia
Status: COMPLETED
Conditions: Oropharyngeal Dysphagia
Interventions: DIETARY_SUPPLEMENT: Modified consistency and volume diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Of DVS SR In Treatment Of Children And Adolescent Outpatients With MDD
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: desvenlafaxine succinate sustained release|DRUG: fluoxetine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Feasibility of the PAINReportIt Guided Relaxation Intervention-INPATIENT
Status: ACTIVE_NOT_RECRUITING
Conditions: Sickle Cell Disease|Stress|Pain
Interventions: BEHAVIORAL: Guided Relaxation video clip|BEHAVIORAL: Sickle Cell Disease Experience Discussion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: AdapTive Personalized Dietitian coacHing, Messaging and pRoduce prescrIption to improVE Healthy Dietary Behaviors
Status: RECRUITING
Conditions: Hypertension
Interventions: BEHAVIORAL: THRIVE Intervention|BEHAVIORAL: Active Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Low Against High Regimen of Proton Pump Inhibitors for Treatment of Acute Peptic Ulcer Bleeding
Status: WITHDRAWN
Conditions: Gastroduodenal Ulcer|Marginal Ulcer|Peptic Ulcer Hemorrhage
Interventions: DRUG: Omeprazole High dose|DRUG: Omeprazole Low dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Topical Lidocaine to Reduce Pain in Patients With Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathy
Interventions: PROCEDURE: Skin biopsy|DRUG: Lidocaine 5% patches
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Berries on Post-meal Blood Sugar
Status: COMPLETED
Conditions: Blood Glucose, Postprandial|Blood Insulin, Postprandial|Hyperglycemia
Interventions: OTHER: Berries|OTHER: No berries
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sorafenib Combined With Chemotherapy for Renal Collecting Duct Carcinoma
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Sorafenib|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Community Active Case Finding Strategies for Detection of Tuberculosis in Cambodia
Status: COMPLETED
Conditions: Tuberculosis
Interventions: OTHER: ACF with a seed-and-recruit model|OTHER: ACF targeting household and neighborhood contacts|OTHER: ACF targeting the older population using mobile screening units|OTHER: Passive case finding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Cochlear Implanted Listening Effort and Hearing Attention
Status: RECRUITING
Conditions: Sensorineural Hearing Loss
Interventions: OTHER: Forced choice psychoacoustic task for the evaluation of modulation detection performance and selective auditory attention. (for both arm)|OTHER: Measurement of the pupil diameter for the evaluation of listening effort during speech perception
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study Assessing the Efficacy, Safety and PK of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum
Status: RECRUITING
Conditions: PIK3CA-related Overgrowth Spectrum (PROS)
Interventions: DRUG: Alpelisib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity(DH)
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: DEVICE: Stannous Fluoride dentifice|OTHER: Sodium Monofluorophosphate dentifrice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Lymph Node Staging With EBUS-TBNA in Clinical N0 Non Small-cell Lung Cancer
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: PROCEDURE: Endobronchial ultrasound transbronchial needle aspiration lymph node staging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Investigate the Safety and Immunogenicity of a Tetravalent Chimeric Dengue Vaccine in Healthy Volunteers Between the Ages of 1.5 - 45 Years
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: TDV|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Type 1 Diabetes,Mindfulness,Yoga,Stress,Health Quality,Glycemic İndex
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes|Stress
Interventions: BEHAVIORAL: Yoga|BEHAVIORAL: Mindfulness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Ventilatory Responses to VHI in Atelectasis Patients
Status: COMPLETED
Conditions: Atelectasis
Interventions: PROCEDURE: Ventilator hyperinflation technique|PROCEDURE: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study to Evaluate the Safety, Tolerance, and Efficacy of Early Treatment With Zidovudine (AZT) in Asymptomatic Infants With HIV Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Optimising Pacemaker Therapy for Contractility
Status: COMPLETED
Conditions: Chronic Heart Failure
Interventions: DEVICE: Personalised rate-response settings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rosuvastatin Gel With 1:1 Mixture of Platelet-rich Fibrin and Bone Graft in Mandibular Degree II Furcation Defects
Status: COMPLETED
Conditions: Furcation Defects
Interventions: DRUG: Rosuvastatin|BIOLOGICAL: platelet rich fibrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Antibiotic Treatment at Home Instead of Intravenous Treatment in Hospital for Resistant Gram Positive Infections
Status: COMPLETED
Conditions: Gram-positive Bacterial Infections|Staphylococcal Infections
Interventions: DRUG: linezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Generic Tretinoin 0.04% Microsphere Gel, 0.04% Retin-A Micro® and Placebo
Status: COMPLETED
Conditions: Acne
Interventions: DRUG: Tretinoin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Efficacy of an Artificial Intelligence Real-Time Coaching SystemSystemSimulatioTraining of Medical Students
Status: COMPLETED
Conditions: Surgical Education
Interventions: BEHAVIORAL: Experimental: Experimental Group - Intelligent Continuous Expertise Monitoring System group|BEHAVIORAL: Experimental Group In-person expert-mediated instruction group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Use of Mindful Compassion and Cannabis Suppositories for Anal Pain Among Men Who Have Sex With Men
Status: COMPLETED
Conditions: Pain;Sexual Intercourse;M
Interventions: COMBINATION_PRODUCT: Cannabis suppositories and mindful-compassion for anal pain|BEHAVIORAL: Mindful-compassion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fish Protein Supplementation and Sarcopenia Outcomes in Carehomes
Status: NOT_YET_RECRUITING
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Blue Whiting Protein Hydrolysate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nutritional Status in Subacute Stroke Patients Under Rehabilitation 2.0
Status: RECRUITING
Conditions: Stroke
Interventions: DEVICE: robotic assisted intervention|DIAGNOSTIC_TEST: hematochemical analysis|DEVICE: BIA, hand grip|DIAGNOSTIC_TEST: nutritional assessment, MNA,|DIAGNOSTIC_TEST: stool sampling|DIAGNOSTIC_TEST: urine sampling|DEVICE: indirect calorimetry analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Establishing Optimal Number of Doses for HPV Vaccination in Children and Adolescents Living With HIV, OPTIMO Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infection
Interventions: BIOLOGICAL: Recombinant Human Papillomavirus Nonavalent Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity of Intramuscular and Intradermal IPV
Status: TERMINATED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: fIPV (0.1 mL) ID|BIOLOGICAL: fIPV (0.1mL) IM|BIOLOGICAL: fIPV (0.2mL) IM|BIOLOGICAL: IPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics of Mmf and Valganciclovir
Status: COMPLETED
Conditions: Kidney Transplant Recipient|Heart Transplant Recipient
Interventions: DRUG: Mycophenolate mofetil|DRUG: Valganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MFOLFIRINOX And Stereotactic Radiotherapy (SBRT) for Pancreatic Cancer With High Risk and Locally Advanced Disease
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: RADIATION: Stereotactic Radiotherapy (SBRT)|DRUG: mFOLFIRINOX|DRUG: Gemcitabine + Nab-paclitaxel|DRUG: Gemcitabine + Capecitabine|PROCEDURE: Pancreatoduodenectomy (Whipple procedure)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 4 Pharmacokinetic Study of Hectorol Injection and Zemplar Injection in CKD Subjects on Hemodialysis
Status: COMPLETED
Conditions: Secondary Hyperparathyroidism
Interventions: DRUG: Hectorol (doxercalciferol injection)|DRUG: Zemplar (Paricalcitol injection)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Morphine for Treatment of Dyspnea in Patients With COPD
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: sustained release morphine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Fiber Breakfasts on Appetite and Weight Change in Overweight Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Oatmeal|DIETARY_SUPPLEMENT: Frosted Flakes|DIETARY_SUPPLEMENT: No Breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy and Safety of Intravitreal Bevacizumab in the Treatment of Choroidal Neovascular Membranes Associated to High Myopia
Status: COMPLETED
Conditions: Myopia|Choroidal Neovascularization
Interventions: DRUG: Intravitreal Injection|DRUG: Photodynamic Therapy (Visudyne)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Clinical Trial of NPB-01 in Patients With Bullous Pemphigoid Unresponsive to Corticosteroids
Status: COMPLETED
Conditions: Bullous Pemphigoid
Interventions: DRUG: NPB-01|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metagenomic NGS for Diagnosis of Pneumonia
Status: NOT_YET_RECRUITING
Conditions: Pneumonia|Diagnosis
Interventions: DIAGNOSTIC_TEST: Metagenomic next-generation sequencing|DIAGNOSTIC_TEST: Standard work-up for pneumonia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Trial of Capecitabine (Xeloda), Oxaliplatin and Irinotecan in Combination With Bevacizumab in 1st Line Treatment of Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Capecitabine (Xeloda), Oxaliplatin, Irinotecan, Bevacizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety Study of TXA127 to Elevate CD4+ T-Lymphocyte Counts in HIV-Infected Patients on Stable HAART Therapy
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: Angiotensin 1-7
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anticholinergic Therapy for Overactive Bladder in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease|Overactive Bladder
Interventions: DRUG: Oxybutynin and darifenacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Hip Flexors Isokinetic Strengthening on Gait Capacities in Subacute Stroke Patients
Status: WITHDRAWN
Conditions: Stroke|Hemiplegia|Gait
Interventions: PROCEDURE: Isokinetic hip flexors strengthening|PROCEDURE: Conventional rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aerobic Dance During Chemotherapy in Breast Cancer Patients With Cognitive Impairment
Status: NOT_YET_RECRUITING
Conditions: Breast Neoplasms|Exercise Therapy|Chemotherapy-Related Cognitive Impairment|Cognitive Dysfunction|Dance Therapy
Interventions: OTHER: Aerobic dance|OTHER: Fast-walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Cognitive Behavioral Therapy in Individuals Exposed to Earthquakes
Status: RECRUITING
Conditions: Earthquake Victim
Interventions: BEHAVIORAL: Cognitive behavioral therapy|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Tolerability of an Intra-Nasal Testosterone Product
Status: COMPLETED
Conditions: Hypogonadism
Interventions: DRUG: Nasobol®|DRUG: Androderm® (Positive Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Capmatinib, Ceritinib, Regorafenib, or Entrectinib in Treating Patients With BRAF/NRAS Wild-Type Stage III-IV Melanoma
Status: TERMINATED
Conditions: ALK Fusion Protein Expression|BRAF wt Allele|Invasive Skin Melanoma|MET Fusion Gene Positive|NRAS wt Allele|NTRK1 Fusion Positive|NTRK2 Fusion Positive|NTRK3 Fusion Positive|RET Fusion Positive|ROS1 Fusion Positive|Stage III Cutaneous Melanoma|Stage IIIA Cutaneous Melanoma|Stage IIIB Cutaneous Melanoma|Stage IIIC Cutaneous Melanoma|Stage IV Cutaneous Melanoma
Interventions: DRUG: Capmatinib|DRUG: Ceritinib|DRUG: Entrectinib|OTHER: Laboratory Biomarker Analysis|DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of the Safety and Efficacy of Anakinra (Recombinant Human Interleukin-1 Receptor Antagonist) in Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Anakinra
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Post-Approval Study Of The Glaukos® iStent® Trabecular Micro-Bypass Stent System In Conjunction With Cataract Surgery
Status: UNKNOWN
Conditions: Primary Open Angle Glaucoma
Interventions: DEVICE: iStent|PROCEDURE: Cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy Study of Osmotic Release Oral System (OROS) Methylphenidate in Participants With Attention-Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: OROS Methylphenidate HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Imaging To Examine The Effect Of Naproxen In Hand Osteoarthritis Patients
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Naproxen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: High-Dose Fluorouracil With or Without Leucovorin Compared With Standard Fluorouracil Plus Leucovorin Following Surgery in Treating Patients With Stage III Colon Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: fluorouracil|DRUG: leucovorin calcium|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: 12 Week,Comparing Safety of HMR1964 & Insulin Aspart Used in Continuous Subcutaneous Infusion in Type 1 Diabetes.
Status: COMPLETED
Conditions: Diabetes, Type I
Interventions: DRUG: Insulin glulisine (HMR1964)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Safety and Effectiveness of The Tixel Fractional System in the Treatment of Meibomian Gland Disfunction
Status: COMPLETED
Conditions: Dry Eye Syndromes|Dry Eye|Meibomian Gland Dysfunction
Interventions: DEVICE: Tixel C|DEVICE: LipiFlow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ursodeoxycholic Acid vs Metformin in Gestational Diabetes Mellitus
Status: UNKNOWN
Conditions: Gestational Diabetes
Interventions: DRUG: Metformin|DRUG: Ursodeoxycholic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation Enhances Immune Response to Bacille-Calmette-Guerin (BCG) Vaccination in Infants
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DIETARY_SUPPLEMENT: Vitamin D3 (cholecalciferol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Melphalan, Prednisone, and Lenalidomide in Treating Patients With Newly Diagnosed Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: lenalidomide|DRUG: melphalan|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Atropine or Glycopyrrolate on the Prevention of Bradycardia During Sedation Using Dexmedetomidine in Adult Patients Undergoing Lower Extremity Surgery Under Spinal Anesthesia
Status: TERMINATED
Conditions: Spinal Anesthesia
Interventions: DRUG: Atropine|DRUG: Glycopyrrolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Modified Thoracoabdominal Nerve Block(M-TAPA) in Pediatric Laparoscopic Appendectomies
Status: ENROLLING_BY_INVITATION
Conditions: Post Operative Pain|Laparoscopic Surgery|Pediatrics|Regional Anesthesia|Local Anesthetic
Interventions: PROCEDURE: M-TAPA Block|PROCEDURE: Local anesthetic infltration to port sites
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Cricoid and Paratracheal Pressures for Occluding Esophagus
Status: COMPLETED
Conditions: Intubation Complication
Interventions: OTHER: Maneuvers for occluding esophagus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Multipeptide Vaccine Plus Toll-Like Receptor Agonists in Melanoma Patients
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: MELITAC 12.1 + Montanide ISA-51 + lipopolysaccharide (LPS)|BIOLOGICAL: MELITAC 12.1 + Montanide ISA-51 + polyICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Peripheral Nerve Blocks in Patients Undergoing Limb Orthopedic Surgery
Status: COMPLETED
Conditions: Pain, Postoperative|Change; Circulatory|Surgical Injury
Interventions: PROCEDURE: 0.25% bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Open-label Safety and Efficacy Study of Recombinant FVIII in Patients With Severe Hemophilia A
Status: COMPLETED
Conditions: Hemophilia A|Severe Hemophilia A
Interventions: BIOLOGICAL: rVIII-SingleChain
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Safety, Tolerability and Pharmacokinetics Following Multiple Doses of LX4211 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LX4211 400 mg|DRUG: LX4211 800 mg|DRUG: LX4211 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-Intensity Extracorporeal Shockwave Therapy for Penile Rehabilitation in Post-Radical Prostatectomy Patients
Status: RECRUITING
Conditions: Erectile Dysfunction Following Radical Prostatectomy
Interventions: DEVICE: Low-Intensity Extracorporeal Shockwave Therapy (LiEWST) - Active|DEVICE: Low-Intensity Extracorporeal Shockwave Therapy (LiEWST) - Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis- EXtended Antiplatelet Monotherapy (HOST-EXAM)
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DRUG: Clopidogrel|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of CErebral Endovascular PROcedures on the Systemic Immune responSe Response
Status: RECRUITING
Conditions: Cerebral Arterio-venous Malformation
Interventions: OTHER: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interferon Alfa Sensitivity in HIV/HCV Persons Before and After HIV Meds
Status: COMPLETED
Conditions: HIV Infection|Hepatitis C
Interventions: DRUG: Antiretroviral therapy (ART)|DRUG: raltegravir|DRUG: Emtricitabine and tenofovir disoproxil fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Alcohol Consumption: Norms, Identities, & Motivations
Status: RECRUITING
Conditions: Binge Drinking|Alcohol Drinking
Interventions: BEHAVIORAL: Induced hypocrisy|BEHAVIORAL: social identity mapping|BEHAVIORAL: Motivational modeling|BEHAVIORAL: motivational interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Angiotensin II for Septic Shock Treatment
Status: SUSPENDED
Conditions: Septic Shock
Interventions: DRUG: Angiotensin II|DRUG: Normal saline|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Virtual Reality on Brain Hemodynamic Activity in Chronic Pain
Status: COMPLETED
Conditions: Chronic Pain|Rheumatoid Arthritis|Virtual Reality
Interventions: OTHER: Immersive virtual reality|OTHER: Non-immersive virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-surgical Spinal Decompression in Patients With Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain|Sciatica|Lumbar Disc Herniation
Interventions: DEVICE: Spinal decompression with BTL-6000 spinal decompression system (BTL Industries Ltd.)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Temozolomide in Treating Older Patients With Newly-Diagnosed Glioblastoma Multiforme or Gliosarcoma
Status: COMPLETED
Conditions: Giant Cell Glioblastoma|Glioblastoma|Gliosarcoma
Interventions: BIOLOGICAL: bevacizumab|DRUG: temozolomide|OTHER: laboratory biomarker analysis|OTHER: immunohistochemistry staining method|GENETIC: microarray analysis|GENETIC: DNA methylation analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deep rTMS for Depression in Older Adults
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: Brainsway H4-Coil Deep TMS System|DEVICE: Brainsway H7-Coil Deep TMS System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Effect of AVE0657 on Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DRUG: AVE0657|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Scalp Acupuncture for Dyskinesia After Ischemic Stroke
Status: UNKNOWN
Conditions: Ischemic Stroke
Interventions: OTHER: Scalp acupuncture|OTHER: Conventional rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Randomized Controlled Trial for Feasibility of Administering an AR Game to Postoperative Pediatric Cancer Patients
Status: UNKNOWN
Conditions: Pediatric Cancer|Surgery
Interventions: DEVICE: ARISE with AR|DEVICE: ARISE without AR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cost-effectiveness of TPMT Pharmacogenetics
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|Crohn Disease|Ulcerative Colitis
Interventions: GENETIC: TPMT genotyping; Drug: azathioprine or 6-mercaptopurine|DRUG: azathioprine (AZA) or 6-mercaptopurine (6-MP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Closed Suction System on the Incidence of Ventilator-associated Pneumonia.
Status: COMPLETED
Conditions: Severe Traumatic Brain Injury|Pancreatic Diseases|Trauma Injury|Seizures|Encephalitis|Abdominal Sepsis
Interventions: DEVICE: Closed suction systems|DEVICE: Conventional suction system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Peripapillary and Macular Vascular Changes of Unilateral Anterior Ischemic Optic Neuropathy: An Optical Coherence Tomography Angiography Study
Status: COMPLETED
Conditions: Non-arteritic Ischemic Optic Neuropathy
Interventions: DIAGNOSTIC_TEST: Optical Coherence Tomography Angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Effect of ASP1941 in Adult Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: ipragliflozin|DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Equivalence of Diclofenac Sodium Gel 3% vs Solaraze ® in the Treatment of Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratoses
Interventions: DRUG: Diclofenac Sodium Gel|DRUG: Solaraze 3% Topical Gel|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Repeat Topical Administration of BOS-475 in Healthy Subjects and Patients With Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: BOS-475|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lima Association in the Control of Type II Diabetes Mellitus.
Status: WITHDRAWN
Conditions: Type2 Diabetes Mellitus
Interventions: DRUG: LIMA association|DRUG: Tradjenta|DRUG: Forxiga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TRANSFIX Zenith® Transection Clinical Study
Status: COMPLETED
Conditions: Thoracic Aorta|Thoracic Injuries|Blunt Injuries
Interventions: DEVICE: Zenith® TX2® Low Profile Endovascular Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Double Blind, Parallel-group Phase 2/3 Trial, to Study Raloxifene in Adult COVID-19 Patients.
Status: COMPLETED
Conditions: SARS CoV 2 Infection
Interventions: DRUG: Raloxifene|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Equilibration Rate Constant (ke0) of Propofol on the Effect Site Concentration for Loss of Consciousness
Status: COMPLETED
Conditions: General Anesthesia
Interventions: DEVICE: Diprifusor (Target-controlled infusion)|DEVICE: Orchestra (Target-controlled infusion)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Treating Persistent Post-concussion Symptoms With Exercise
Status: COMPLETED
Conditions: Brain Injuries, Traumatic|Concussion, Brain|Mild Traumatic Brain Injury|Post-Concussion Syndrome
Interventions: BEHAVIORAL: Aerobic Exercise Protocol|BEHAVIORAL: Stretching Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Perineural Dexmedetomidine in Adductor Canal Block
Status: COMPLETED
Conditions: Arthroscopic Medial Meniscectomy
Interventions: DRUG: Dexmedetomidine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Can 4 Weeks of Exercise Program Change Quadriceps Architecture in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid|Knee Osteoarthritis|Quadriceps Muscle Atrophy|Ultrasonography|Exercise
Interventions: PROCEDURE: Quadriceps femoris isometric home-based exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Olmesartan/HCTZ 40/12.5 mg Combination Therapy Versus Olmesartan Medoxomil 40 mg Monotherapy in Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: OM 40|DRUG: OM/HCTZ 40/12.5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT