pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Dose Finding and Pharmacokinetics/Pharmacodynamics Study of Apatinib in the Treatment of Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Apatinib|DRUG: apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritious Eating With Soul (The NEW Soul Study)
Status: COMPLETED
Conditions: Cardiovascular Disease Risk Factors|Overweight and Obesity
Interventions: BEHAVIORAL: Dietary Intervention Meetings|BEHAVIORAL: Physical Activity|BEHAVIORAL: Podcasts/Mailings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Does the Use of a Moisture Chamber Decrease the Incidence of Corneal Abrasions in Critically Ill Pediatric Patients?
Status: COMPLETED
Conditions: Eye Injuries|Critically Ill
Interventions: PROCEDURE: plastic wrap over eye & lubrication applied q6 hrs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prognostic Value of the 6-minute Stepper Test in Non-small Cell Lung Cancer Surgery
Status: COMPLETED
Conditions: Lung Neoplasm Malignant|Resectable Lung Non-Small Cell Carcinoma
Interventions: DIAGNOSTIC_TEST: Six minutes stepper test (6MST)|DIAGNOSTIC_TEST: Sit to stand test (STST)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The LOw PRESSuRE Trial: Laparoscopic Optimization With Pressure Reduction
Status: NOT_YET_RECRUITING
Conditions: Surgery|Laparoscopic|Laparoscopy|Penumoperitoneum|Post-operative Pain|Post-operative Recovery
Interventions: PROCEDURE: Low Pressure Penumoperitoneum|OTHER: Standard Pressure Group (No intervention- active comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Collaborative Model to Improve Blood Pressure (BP) Control and Minimize Racial Disparities
Status: COMPLETED
Conditions: Hypertension|Asthma
Interventions: OTHER: PPCM Asthma|OTHER: 24 Month PPCM BP|OTHER: 9 Month PPCM BP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Use and Effectiveness of COVID-19 Vaccines Using State Vaccine Registries and Insurance Claims Data
Status: RECRUITING
Conditions: SARS-CoV-2|COVID-19|Post-Acute COVID-19 Syndrome
Interventions: BIOLOGICAL: Pfizer-BioNTech COVID-19 mRNA vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Quality of Life of Adult Cancer Survivors Who Have Undergone a Previous Bone Marrow or Peripheral Stem Cell Transplant for a Childhood Hematologic Cancer
Status: COMPLETED
Conditions: Leukemia|Lymphoma|Myelodysplastic Syndromes|Quality of Life
Interventions: PROCEDURE: cognitive assessment|PROCEDURE: management of therapy complications|PROCEDURE: psychosocial assessment and care|PROCEDURE: quality-of-life assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE)
Status: TERMINATED
Conditions: Bronchopulmonary Dysplasia|Respiratory Distress Syndrome|Infant, Newborn|Infant, Low Birth Weight|Infant, Small for Gestational Age|Infant, Premature
Interventions: PROCEDURE: Minimal mechanical ventilation management|PROCEDURE: Routine mechanical ventilation management|DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Focal Vibration Within a Multicomponent Exercise Program for Older Women With Osteoporosis a Single-blind Clinical Trial
Status: UNKNOWN
Conditions: Osteoporosis|Osteoporosis, Postmenopausal
Interventions: OTHER: Focal Vibration|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Renal Impairment on JNJ-42847922 in Adult Participants
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: JNJ-42847922
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of Flash Mediation Therapy
Status: COMPLETED
Conditions: Dementia
Interventions: BEHAVIORAL: 2 months control condition - 4 months chariot-flash|BEHAVIORAL: 4 months control condition-2 months chariot flash
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Omacetaxine and Decitabine in Acute Myelogenous Leukemia (AML) and Myelodysplastic Syndrome (MDS)
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: Omacetaxine|DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of PK and Safety of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Subjects With Various Degrees Of Renal Function
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Tebipenem pivoxil hydrobromide (TBPM-PI-HBr)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impact of Exercise and Affirmations (IntenSati) on Addiction-related Cognitive and Psychosocial Deficits
Status: COMPLETED
Conditions: Drug Dependence|Alcohol Dependence
Interventions: BEHAVIORAL: IntenSati
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic ABCB5-positive Stem Cells for Treatment of Epidermolysis Bullosa
Status: COMPLETED
Conditions: Recessive Dystrophic Epidermolysis Bullosa
Interventions: BIOLOGICAL: allo-APZ2-EB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 7.5F Versus 9.2F Flexible Ureteroscopy for the Treatment of 1-2cm Renal Calculi on Postoperative Infection
Status: UNKNOWN
Conditions: Kidney Stones
Interventions: PROCEDURE: 7.5fr ultra-fine ureteroscopy|PROCEDURE: 9.2fr Ureteroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Post-dilution On-line Hemodiafiltration and Hemodialysis
Status: COMPLETED
Conditions: End-Stage Renal Disease
Interventions: PROCEDURE: post-dilution on-line hemodiafiltration|PROCEDURE: high flux hemodialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study With an Innovative Equipment to Monitor and Control SALT During Cooking
Status: UNKNOWN
Conditions: Salt; Excess|Hypertension
Interventions: DEVICE: SALT CONTROL H equipment to control and monitor salt during cooking process
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Living Donor Liver Transplantation for Intrahepatic Cholangiocarcinoma
Status: NOT_YET_RECRUITING
Conditions: Living Donor Liver Transplantation|Liver Transplantation|Neoadjuvant Therapy
Interventions: PROCEDURE: Living donor liver transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identifying Stress Urinary Incontinence in Women With Pelvic Organ Prolapse
Status: COMPLETED
Conditions: Stress Urinary Incontinence|Pelvic Organ Prolapse
Interventions: PROCEDURE: Urodynamics
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: PK of Pacritinib in Patients With Mild, Moderate, Severe Renal Impairment and ESRD Compared to Healthy Subjects
Status: COMPLETED
Conditions: Myelofibrosis
Interventions: DRUG: Pacritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical and Virological Efficacy of Pegylated Interferon Alpha in the Treatment of Rhinovirus Infection in Patients With Primary Hypogammaglobulinemia: Randomized Controlled Trial
Status: UNKNOWN
Conditions: Rhinovirus Infection
Interventions: DRUG: pegylated interferon alfa 2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DJ-927 and Capecitabine in Treating Patients With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: DJ-927|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metoclopramide in Upper Gastrointestinal Bleed
Status: RECRUITING
Conditions: Upper GI Bleeding|Bleeds Gastric|Bleed Ulcer|Hemorrhage Gastric|Hemorrhage; Ulcer
Interventions: DRUG: Metoclopramide 10mg|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors
Status: NOT_YET_RECRUITING
Conditions: Pediatric Tumor of CNS|Pediatric Tumor of Brain|Diffuse Midline Glioma, H3 K27M-Mutant|Pediatric Tumor of Brain Stem|Pineocytoma|Choroid Plexus Carcinoma, Childhood|Spinal Cord Tumor|High Grade Glioma
Interventions: DRUG: NEO100
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dismantling Exposure, Relaxation, and Rescripting Therapy
Status: RECRUITING
Conditions: Frequent Trauma-related Nightmares
Interventions: BEHAVIORAL: Exposure, Relaxation, and Rescripting Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nasal Intermittent Positive Pressure Ventilation(NIPPV) vs Continuous Positive Airway Pressure for Respiratory Distress Syndrome
Status: UNKNOWN
Conditions: Nasal Intermittent Positive Pressure Ventilation|Nasal Continuous Positive Airway Pressure
Interventions: DEVICE: NIPPV|DEVICE: NCPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 68Gallium-FAPI PET/CT Imaging in Chronic Inflammatory and Fibrotic Diseases
Status: NOT_YET_RECRUITING
Conditions: Inflammatory Disease
Interventions: DIAGNOSTIC_TEST: 68Ga-FAPI46
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Active Release Technique and Abdominal Drawing-Maneuver on Pain and Quality of Life in Patients With Chronic Low Back Pain
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: DIAGNOSTIC_TEST: Active Release Technique|DIAGNOSTIC_TEST: Abdominal Drawing-Maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Atrial Fibrillation and Congestive Heart Failure Trial
Status: COMPLETED
Conditions: Atrial Fibrillation|Congestive Heart Failure
Interventions: OTHER: Rate vs rhythm control strategies for atrial fibrillation|OTHER: Rate vs rhythm control strategies in atrial fibrillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Parenteral Nutrition (PN) Using Eurotubes® vs. 2/3-chamber Bags in Subjects With Solid Tumors Requiring PN (PEKANNUSS)
Status: TERMINATED
Conditions: Solid Tumor
Interventions: DEVICE: Parenteral Nutrition Bag Eurotube|DEVICE: Parenteral Nutrition 2/3 chamber Bag
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tunnel Attachments With Clear Aligners vs Clear Aligners
Status: UNKNOWN
Conditions: Malocclusion
Interventions: DEVICE: Tunnel attachments and light Nickel Titanium wire|DEVICE: Clear Aligner therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Burnout and Distress preventiOn With caNnabidiol in Front-line Health Care workerS deAling wIth COVID-19
Status: COMPLETED
Conditions: Covid19|Burn Out|Post Traumatic Stress Disorder
Interventions: DRUG: Cannabidiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Patient Reported Outcomes and Patient Education in Cellular Therapy Patients
Status: COMPLETED
Conditions: Stem Cell Transplant|CAR T-Cell Transplant|CAR T-Cell Therapy|Cellular Therapy|Hematopoietic Stem Cell Transplant|HSCT|Multiple Myeloma|Leukemia|Lymphoma
Interventions: BEHAVIORAL: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PREterM FOrmula Or Donor Breast Milk for Premature Babies
Status: COMPLETED
Conditions: Adiposity|Insulin Resistance|Metabolomic Profile|microRNA Profile
Interventions: OTHER: Unfortified Human donor Milk used to make up any shortfall in mother's own milk|OTHER: Fortified Human donor Milk used to make up any shortfall in mother's own milk|OTHER: Preterm Formula used when there is a shortfall in mother's own milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of the Treatment of Vascular Endothelial Growth Factor(VEGF)Signaling Pathway Inhibitor-Induced Hypertension
Status: TERMINATED
Conditions: Treatment Induced Hypertension
Interventions: DRUG: Minoxidil|DRUG: Hydralazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regorafenib Plus FOLFIRI With Irinotecan Dose Escalated in Patients With Previously Treated Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Regorafenib|GENETIC: UGT1A1 genotyping (TA6/TA6)|GENETIC: UGT1A1 genotyping (TA6/TA7)|GENETIC: UGT1A1 genotyping (TA7/TA7)|DRUG: Leucovorin and 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)
Status: RECRUITING
Conditions: Alpha 1-Antitrypsin Deficiency
Interventions: DRUG: BEAM-302
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-Based Interventions for MDD
Status: UNKNOWN
Conditions: Depression|Medication Adherence
Interventions: DRUG: antidepressant treatment|OTHER: antidepressant treatment combined with Internet-based interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stepping up to Health - for Veterans With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: BEHAVIORAL: automated internet-mediated walking program|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Brief Behavioral Treatment for Insomnia in Veterans With Posttraumatic Stress Disorder
Status: RECRUITING
Conditions: Posttraumatic Stress Disorder|Insomnia Disorder
Interventions: BEHAVIORAL: Brief Behavioral Treatment for Insomnia (BBTI)|BEHAVIORAL: Progressive Muscle Relaxation Training (PMRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ad-RTS-hIL-12 With Veledimex in Combination With Nivolumab in Subjects With Glioblastoma; a Substudy to ATI001-102
Status: COMPLETED
Conditions: Glioblastoma
Interventions: BIOLOGICAL: Ad-RTS-hIL-12|DRUG: veledimex|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First-In-Human Study With a Single Ascending Dose of UCB7858 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: UCB7858|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Novel Multimodal Pain Control Protocol for Minimally Invasive Gynecologic Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Narcotic Use|Cryotherapy Effect
Interventions: OTHER: Opioid-sparing multimodal pain management|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-Dose Intravenous Interleukin-2 in Treating Patients With Metastatic Renal Cell Carcinoma (Kidney Cancer) That Has Not Responded to Previous Low-Dose Intravenous or Subcutaneous Interleukin-2
Status: UNKNOWN
Conditions: Kidney Cancer
Interventions: BIOLOGICAL: aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Postoperation Maintenance Therapy for Resectable Liver Metastases of Colorectal Cancer Guided by ctDNA
Status: RECRUITING
Conditions: Colorectal Cancer|Liver Metastases|Circulating Tumor Cell|Cancer, Therapy-Related
Interventions: PROCEDURE: Colorectal resection surgery.|DRUG: FOLFOX chemotherapy regimen|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multiple Dose Safety And Pharmacokinetic (PK) Study Of PF-06427878 In Overweight-Obese, Otherwise Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Placebo|DRUG: PF-06427878
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 1 Study in Healthy Subjects to Evaluate the Effect of Rifampin on the Pharmacokinetics of IPI-145
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: IPI-145|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nonneoplastic Epithelial Disorders of Vulva and High Intensity Focused Ultrasound
Status: UNKNOWN
Conditions: Vulva Intraepithelial Nonneoplastic
Interventions: DEVICE: the high intensity focused ultrasound (Mianyang Sonic electronic LLC)|DRUG: Fu Tiankang disposable vaginal filling suppository, Albothyl (Policresulen Solution) , and the gynecologic medical antimicrobial dressing gel (chitosan gel).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RFR Change of Precise Segmental Versus Complete Renal Arterial Clamping During LPN for Clinical T1 RCC
Status: UNKNOWN
Conditions: Renal Cell Carcinoma
Interventions: PROCEDURE: precise segmental renal arterial clamping|PROCEDURE: laparoscopic partial nephrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Brief Transdiagnostic Group CBT for Adolescents With Internalizing Problems: A Randomized Waitlist Controlled Trial
Status: UNKNOWN
Conditions: Anxiety Disorders|Depressive Disorder|Anxiety|Depression
Interventions: BEHAVIORAL: Brief Transdiagnostic group-based Cognitive-Behavioral Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Skin Toxicity Dosing of IRESSA (Gefitinib) in Squamous Cell Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Head and Neck Neoplasms
Interventions: DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficiency Study for Acute Radiation-induced and Chemotherapy-induced Pulmonary Fibrosis With Bevasizumab
Status: RECRUITING
Conditions: Pulmonary Fibrosis
Interventions: DRUG: Bevacizumab|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Camrelizumab in Combination With Cetuximab and Chemotherapy for Relapsed/Metastatic HNSCC Patients
Status: RECRUITING
Conditions: Squamous Cell Carcinoma of Head and Neck
Interventions: DRUG: Camrelizumab+cetuximab+chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation and Comparison of Systemic Exposure to Ibuprofen After Single Oromucosal Versus Oral Administrations
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: V0498 - A mg|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enstilar® Foam in the Treatment of Chronic Plaque Psoriasis in Patients With Skin of Color
Status: COMPLETED
Conditions: Plaque Psoriasis|Psoriasis
Interventions: DRUG: Enstilar® foam|DRUG: Vehicle foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Safety, Tolerability, Pharmacokinetics and Dynamic Effects of Different Doses of the Study Drug EMD 525797 in Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Bone Metastases
Interventions: BIOLOGICAL: EMD 525797
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: US & HILT Comparative Effect on Neuropathic Pain, Strength & QOF in Diabetic Foot
Status: RECRUITING
Conditions: Diabetic Foot|Diabetic Neuropathies
Interventions: OTHER: ultrasound|OTHER: high intensity laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity and Safety of Tetanus, Diphtheria and Mono Component Acellular Pertussis (TdaP) Vaccine in Comparison to Tetanus and Diphtheria (Td) Vaccine When Given as Booster Vaccinations to Adults
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: TdaP vaccine SSI|BIOLOGICAL: Td vaccine SSI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase Ib/II Study of LY2780301 in Combination With Weekly PACLITAXEL in HER2-metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: LY2780301 + paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Melatonin on Sleep Disturbances in Patients With Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: DRUG: Melatonin(Circadin®)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: In Vivo Efficacy of Artemether-lumefantrine and Amodiaquine-artesunate in Mozambican Children (MEFI_III)
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Coartem™ (Artemether-lumefantrine combination)|DRUG: Winthrop™ (Amodiaquine-artesunate combination)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effects of Autologous Adipose-Derived Stromal Cells in Patients With Diffuse Lesions in the Brain
Status: WITHDRAWN
Conditions: Brain Lesion (General)
Interventions: PROCEDURE: harvesting and implantation of adipose derived stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anlotinib Combination With Vinorelbine in the HER2- Advanced Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: anlotinib and vinorelbine|DRUG: Vinorelbine injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rubidium-82 PET and Tc-99m-MIBI SPET: A Head to Head Comparison
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Rubidium-82|DRUG: Sestamibi. reconstitution with sodium pertechnetate (99mTc)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dapagliflozin and Measures of Cardiovascular Autonomic Function in Patients With Type 2 Diabetes (T2D)
Status: COMPLETED
Conditions: Type2 Diabetes|Cardiovascular Diseases
Interventions: DRUG: Dapagliflozin|DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Four Treatment Modalities in Prostate Cancer With Low or "Early Intermediate" Risk
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: PROCEDURE: radical prostatectomy|RADIATION: percutaneous radiation therapy|RADIATION: permanent seed implantation|PROCEDURE: Active Surveillance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iron-Biofortified Beans Intervention in Mexico
Status: COMPLETED
Conditions: Iron-deficiency|Anemia
Interventions: OTHER: Iron-biofortified beans|OTHER: Control beans
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics, Safety and Tolerability of Rising Doses of Buscopan® in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Hyoscine butylbromide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections
Status: NOT_YET_RECRUITING
Conditions: Surgical Site Infection
Interventions: DRUG: Povidone-Iodine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Abuse Potential of Istradefylline
Status: COMPLETED
Conditions: Drug Abuse
Interventions: DRUG: Istradefylline|DRUG: Phentermine 45 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pan-VEGF Blockade for the Treatment of Retinopathy of Prematurity (BLOCK-ROP)
Status: WITHDRAWN
Conditions: Retinopathy of Prematurity
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Factors Associated With an Evolution in the Quality of Life of Diabetic Patients With Chronic, Wound-free Charcot Foot
Status: RECRUITING
Conditions: Charcot Joint of Foot|Osteoarthropathy
Interventions: OTHER: Filling in the SF-36, FAAM-F, PHQ-9, PHQ-2 and the simplified version of the EPICES score questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cortical Dynamics of Inhibitory Control: A Concurrent tDCS-MEG Study
Status: COMPLETED
Conditions: Impulsive Behavior
Interventions: DEVICE: Anodal tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Attention Shaping Procedures for Improving Psychosocial Skills Among Adults With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Social skills training with attention shaping procedures|BEHAVIORAL: Social skills training without attention shaping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tofacitinib Bioequivalence Study Comparing Tablets And Capsules
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: tofacitinib 10 mg|DRUG: tofacitinib 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of the Elevate Anterior and Apical Prolapse Repair System Compared to Native Tissue Repair for Pelvic Organ Prolapse
Status: TERMINATED
Conditions: Pelvic Organ Prolapse
Interventions: DEVICE: Elevate Anterior and Apical|PROCEDURE: Native Tissue Repair for pelvic organ prolapse
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Saffron Supplementation in Stargardt's Disease
Status: UNKNOWN
Conditions: Retinal Degeneration|Genetic Disease|Single-Gene Defects|Macular Dystrophy
Interventions: DIETARY_SUPPLEMENT: Saffron supplementation|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Saxagliptin on EPCs as a Cellular Biomarker for Evaluating Endothelial Dysfunction in Early T2DM Patients
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Saxagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intranasal Insulin on LH Concentrations in Man
Status: COMPLETED
Conditions: Hypogonadotropic Hypogonadism
Interventions: DRUG: intranasal insulin|DRUG: placebo (intranasal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Advanced and Metastatic Solid Tumors With MIL97
Status: RECRUITING
Conditions: Advanced or Metastatic Solid Tumor
Interventions: DRUG: Recombinant Humanized Monoclonal Antibody MIL97 for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DAPERB 3,4-DiAminoPyridine and Electrophysiological Response in Brugada Syndrome
Status: TERMINATED
Conditions: Brugada Syndrome
Interventions: DRUG: 3,4-Di-amino-Pyridine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Bazedoxifene Acetate In Osteoporosis In Postmenopausal Women
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Bazedoxifene Acetate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis
Status: COMPLETED
Conditions: Meningitis, Cryptococcal|HIV Infections
Interventions: DRUG: Fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Musculoskeletal Ultrasound of the Ankles in Erysipelas-like Erythema of Familial Mediterranean Fever
Status: UNKNOWN
Conditions: Erysipelas
Interventions: DEVICE: Musculoskeletal ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Postoperative Opioid-Sparing Effect of a Pecto-Intercostal Fascial Block and Opioid-Free Anesthesia.
Status: UNKNOWN
Conditions: Opioid Free Anaesthesia|Opioid Anaesthesia
Interventions: PROCEDURE: Opioid Free Anesthesia|PROCEDURE: Traditional Anesthetic Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Atenolol for the Prevention of Osteoporosis (APO)
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DRUG: Atenolol 50 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of How Indinavir (an Anti-HIV Drug) and Rifabutin (a Drug Used to Treat MAC, an HIV-Associated Disease) Interact in HIV-Positive and HIV-Negative Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Rifabutin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of Multiple Rising Doses of BI 113608 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 113608 PIB bid|DRUG: Placebo to BI 113608 PIB bid|DRUG: Placebo to BI 113608 PIB bid|DRUG: Placebo to BI 113608 PIB qd|DRUG: Placebo to BI 113608 PIB bid|DRUG: BI 113608 PIB bid|DRUG: BI 113608 PIB bid|DRUG: BI 113608 PIB qd
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Safety/ Efficacy of Brivaracetam (BRV) Used as Adjunctive Treatment in Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization
Status: ENROLLING_BY_INVITATION
Conditions: Partial Seizures With or Without Secondary Generalization|Epilepsy
Interventions: DRUG: Brivaracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Propofol Versus Midazolam to Sedate Critically Brain Injury; Measurement of Cytokine Response and Assessment of Function
Status: TERMINATED
Conditions: Traumatic Brain Injury
Interventions: DRUG: Intravenous sedation using propofol|DRUG: Intravenous sedation with midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dual Inhibition of EGFR With Afatinib and Cetuximab in the Treatment of Advanced Squamous Cell Cancers of the Head and Neck
Status: RECRUITING
Conditions: Squamous Cell Cancers of the Head and Neck
Interventions: DRUG: cetuximab|DRUG: afatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrashort GnRH Agonist/Antagonist Versus GnRH Antagonist IVF
Status: UNKNOWN
Conditions: Infertility
Interventions: OTHER: ARM A- Agonist/Antagonist protocol|OTHER: ARM B- Antagonist protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting
Status: COMPLETED
Conditions: Keratoconus|Ocular Surface Disease|Pellucid Marginal Corneal Degeneration|Ectasia|Corneal Trauma|Corneal Scar|Dry Eye Syndromes|Keratoconjunctivitis Sicca|Sjogren's Syndrome
Interventions: DEVICE: Ocular surface optical coherence tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy
Status: COMPLETED
Conditions: Epiretinal Membrane|Macular Hole|Proliferative Diabetic Retinopathy
Interventions: OTHER: Dye of Lutein, Zeaxanthin and Brilliant Blue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacogenomic & Phase II Study of Gemcitabine and Pemetrexed in Non-Small-Cell Lung Cancer.
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Gemcitabine|DRUG: Pemetrexed|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of VIRAZOLE® in Hospitalized Adult Participants With Respiratory Distress Due to COVID-19
Status: WITHDRAWN
Conditions: COVID19
Interventions: DRUG: 50 mg/mL Virazole|DRUG: 100 mg/mL Virazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study on Whey Protein Supplementation in Non Alcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease|Obesity
Interventions: DIETARY_SUPPLEMENT: ProWHEY 94 CFM, SponserR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of De-escalated Adjuvant Radiation Therapy for Human Papillomavirus (HPV)-Associated Oropharynx Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Oropharynx Cancer
Interventions: RADIATION: Adjuvant Radiation Therapy|DRUG: Docetaxel|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: How Much Does Reduced Dosing of Latanoprost and Dorzolamide-timolol Affect Pressure?
Status: TERMINATED
Conditions: Glaucoma, Open-Angle|Glaucoma; Drugs
Interventions: DRUG: dorzolamide/timolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Immunology Study of a Modified Vaccinia Vaccine for HER-2(+) Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: MVA-BN-HER2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: m-Health System for Tracking Kangaroo Mother Care and Temperature in Southern India
Status: COMPLETED
Conditions: Preterm Infant|Low Birth Weight Infant|Kangaroo Mother Care|Hypothermia, Newborn|Fever
Interventions: DEVICE: Wearable device with smart mobile phone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Clinical Study of Xin'an Medicine in the Treatment of Bi Syndrome
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Xinfeng capsule|DRUG: leflunomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of NOx and Conjugated Linoleic Acid on Asthmatics
Status: COMPLETED
Conditions: Asthma
Interventions: DIETARY_SUPPLEMENT: Conjugated Linolenic Acid|DRUG: Sodium Nitrite|DRUG: Sodium Nitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Health/Outcomes: Improvements Created by Exercise and Education in SCI (CHOICES)
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: OTHER: Body Weight Supported Treadmill Training|OTHER: Arm Cycle Ergometry Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Corneal Transplantation Guided by OCT RESCAN
Status: UNKNOWN
Conditions: Cornea|Keratoconus|Bullous Keratopathy|Corneal Dystrophy
Interventions: PROCEDURE: Lumera Microscope with OCT RESCAN|PROCEDURE: Conventional Microscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ONO-7475 in Patients With Acute Leukemias
Status: TERMINATED
Conditions: Acute Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: ONO-7475 3mg once daily|DRUG: ONO-7475 6mg once daily|DRUG: ONO-7475 10mg once daily|DRUG: ONO-7475 6mg + Venetoclax (70-400mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Chronic Insomnia According to Yin Yang Theory and Its Correlation With Circadian Rhythm
Status: COMPLETED
Conditions: Chronic Insomnia|Circadian Rhythm|Traditional Chinese Medicine
Interventions: DRUG: Suanzaoren Decoction and Huanglian Wendan Decoction|DRUG: Estazolam 1Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2B/3 Double-blinded Placebo-controlled
Status: COMPLETED
Conditions: Chlamydia Trachomatis Infection
Interventions: DRUG: EVO100|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bevacizumab or Cetuximab And Gemcitabine Hydrochloride, Capecitabine, and Radiation Therapy in Treating Patients With Pacreatic Cancer That Has Been Completely Removed By Surgery
Status: COMPLETED
Conditions: Stage IA Pancreatic Cancer|Stage IB Pancreatic Cancer|Stage IIA Pancreatic Cancer|Stage IIB Pancreatic Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: gemcitabine hydrochloride|DRUG: capecitabine|RADIATION: radiation therapy|BIOLOGICAL: bevacizumab|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sodium Alginate Oral Suspension to Treat Non-erosive Gastro-esophageal Reflux Disease
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease|Heartburn
Interventions: DRUG: Sodium alginate|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Weekly PROCRIT (Epoetin Alfa) or Placebo on Anemia and Quality of Life in Children With Cancer Undergoing Chemotherapy
Status: COMPLETED
Conditions: Anemia|Hodgkin Disease|Leukemia|Lymphoma, Non-hodgkin
Interventions: DRUG: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Addressing of Efficacy and Safety of Femtosecond-laser Assisted Versus Manual Lens Fragmentation Procedure
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Femtosecond laser cataract surgery|PROCEDURE: Manual cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn More About How Well BAY 2927088 Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Human Epidermal Growth Factor Receptor 2 (HER2)
Status: RECRUITING
Conditions: Advanced Non-small Cell Lung Cancer|HER2 Mutation
Interventions: DRUG: BAY2927088|DRUG: Pembrolizumab|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caffeine/Propranolol Intervention for Acute Migraine
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: DRUG: caffeine/propranolol combination tablet|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Meat-based Versus Pesco-vegetarian Diet and Colorectal Cancer
Status: COMPLETED
Conditions: Nutrition Aspect of Cancer|Diet Modification|Cancer of Colon
Interventions: BEHAVIORAL: Meat-based diet|DIETARY_SUPPLEMENT: Meat-based diet supplemented with alpha-tocopherol (MBD-T)|BEHAVIORAL: Pesco-vegetarian diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Evaluation of the Pharmacokinetics and Pharmacodynamics of AP09004 in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: AP09004|DRUG: Carbidopa/Levodopa, immediate release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRACTECAL-PKPD Sub Study
Status: UNKNOWN
Conditions: Multi-drug Resistant Tuberculosis|Extensively Drug-Resistant Tuberculosis|Pulmonary Tuberculosis
Interventions: DRUG: Bedaquiline|DRUG: Pretomanid|DRUG: Moxifloxacin|DRUG: Linezolid|DRUG: Clofazimine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Hip Adduction Combination With Knee Extension Exercise on Morphology of Quadriceps Muscles, Pain and Functional Outcomes in Patients With PFPS
Status: UNKNOWN
Conditions: Patellofemoral Syndrome
Interventions: PROCEDURE: exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: ECT