pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety Study of Indacaterol Maleate/Glycopyrronium Bromide in Chronic Obstructive Pulmonary Disease (COPD) Patients.
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: QVA149|DRUG: Umeclidinium/vilanterol|DRUG: Placebo (umeclidinium/vilanterol )|DRUG: Placebo (QVA149)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tributyrin: Time Course & Efficacy to Improve Health & Performance
Status: RECRUITING
Conditions: Metabolite Concentration|Gut Permeability|Inflammation|Sleep|Performance
Interventions: DIETARY_SUPPLEMENT: CoreBiome|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: BIBF 1120 in Bevacizumab Resistant, Persistent, or Recurrent Epithelial Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Cancer
Interventions: DRUG: BIBF 1120
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Local Anesthetic Concentration for Continuous Femoral Nerve Blocks
Status: COMPLETED
Conditions: Total Knee Arthroplasty|Knee Pain
Interventions: DRUG: 0.1% and 0.4% perineural ropivicaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Energy Expenditure and Cardiovascular Health Effects From Tai Chi and Walking Exercise
Status: COMPLETED
Conditions: Physical Activity
Interventions: BEHAVIORAL: 12-week instructor-led Tai Chi training program|BEHAVIORAL: 12-week instructor-led brisk walking training program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Absorbable Sutures , Non Absorbable Sutures or Biologic Fibrin Glue for Protesic Mesh Fixing in Lichtenstein Technique for Primitive Groin Hernia Repair: a Randomized Prospective Multicentric Trial
Status: UNKNOWN
Conditions: Hernia, Inguinal
Interventions: PROCEDURE: Lichtenstein technique groin hernia repair with mesh. Use of absorbale sutures for mesh fixation|PROCEDURE: Lichtenstein technique groin hernia repair with mesh. Use of non absorbable sutures for mesh fixation|PROCEDURE: Lichtenstein technique groin hernia repair with mesh. Use of fibrin biological glue for mesh fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Avastin (Bevacizumab) in Combination With Xelox and Tarceva in Patients With Metastatic Colorectal Cancer.
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: bevacizumab [Avastin]|DRUG: eloxatin|DRUG: capecitabine [Xeloda]|DRUG: erlotinib [Tarceva]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quality of Life After Primary TORS vs IMRT for Patients With Early-stage Oropharyngeal Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Oropharynx Cancer|Oropharynx Squamous Cell Carcinoma|Carcinoma, Squamous Cell|Carcinoma|Oropharyngeal Neoplasms|Neoplasms, Squamous Cell|Neoplasms, Glandular and Epithelial|Neoplasms by Histologic Type|Pharyngeal Neoplasms Malignant and Unspecified|Otorhinolaryngologic Neoplasms|Head and Neck Neoplasms|Neoplasms by Site|Otorhinolaryngologic Diseases|Pharyngeal Diseases|Papillomavirus Infections|Virus Diseases|DNA Virus Infections|Tumor Virus Infections|Quality of Life
Interventions: RADIATION: Intensity-Modulated Radiation Therapy (IMRT)|DRUG: Cisplatin|DRUG: Nimorazole.|PROCEDURE: Transoral Robotic Surgery (TORS) with neck dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine in Treating Patients With Recurrent or Persistent Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Adenocarcinoma|Endometrial Adenosquamous Carcinoma|Endometrial Clear Cell Adenocarcinoma|Recurrent Uterine Corpus Carcinoma
Interventions: DRUG: Gemcitabine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes
Status: RECRUITING
Conditions: Prediabetic State|Atherosclerosis|Metformin
Interventions: DRUG: Metformin XR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Postoperative Immobilization on Healing After Rotator Cuff Arthroscopic Repair
Status: UNKNOWN
Conditions: Rotator Cuff Tear
Interventions: PROCEDURE: Postoperative early passive motion|OTHER: Sling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preliminary Clinical Study of UTAA09 Injection in the Treatment of Relapsed/Refractory Autoimmune Diseases
Status: NOT_YET_RECRUITING
Conditions: Systemic Lupus Erythematosus|Idiopathic Inflammatory Myopathies|Systemic Sclerosis|Sjogren's Syndrome|Rheumatoid Arthritis|Immune Thrombocytopenia|Primary Biliary Cholangitis
Interventions: BIOLOGICAL: T cell injection targeting CD19 chimeric antigen receptor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Effect of a Combination of Cetirizine With Pseudoephedrine Versus Cetirizine Alone on Symptoms in Patients With Allergic Rhinitis
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Cetirizine|DRUG: Pseudoephedrine|DRUG: Cetirizine with Pseudoephedrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Value of Heart-Fatty Acid Binding Protein and Ischemia Modified Albumin as Biochemical Markers on Non ST Segment Elevation Acute Coronary Syndrome at the Emergency Room.
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: OTHER: Measure of Initial heart fatty acid binding protein and ischemia modified albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Diaphragmatic Dysfunction After Ultrasound-guided Supraclavicular Block With Single or Double Injection Technique
Status: WITHDRAWN
Conditions: Anesthesia
Interventions: PROCEDURE: Single injection supraclavicular nerve block|PROCEDURE: Double injection supraclavicular nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect Of Itraconazole On The Pharmacokinetics Of Palbociclib
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Palbociclib Alone|DRUG: Palbociclib plus itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Study of Dendritic Cell Vaccine With and Without Cyclophosphamide to Treat Stage IV Melanoma Patients
Status: TERMINATED
Conditions: Malignant Melanoma Stage IV
Interventions: BIOLOGICAL: DC Vaccine & Cyclophosphamide|BIOLOGICAL: DC Vaccine & Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Magnesium NOVAMag® Membrane vs. Collagen Jason® Membrane in Patients Requiring Guided Bone Regeneration
Status: RECRUITING
Conditions: Guided Bone Regeneration (GBR)|Ridge Augmentation|Periodontal Bone Defect
Interventions: DEVICE: GBR surgery including membrane placement|PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investıgatıon Of The Effect Of Traınıng And Counselıng Provıded By Tele Nursing
Status: NOT_YET_RECRUITING
Conditions: Musculoskeletal Diseases
Interventions: OTHER: control group|OTHER: experimental group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acute Meat and Alternative Intake (PRotEin DIet SatisfacTION Trial 3)
Status: COMPLETED
Conditions: Diet, Healthy|Protein; Disease
Interventions: OTHER: Food. Beef, Pasture-raised|OTHER: Food. Beef, Grain-fed|OTHER: Food. Meat alternative|OTHER: Food, Lamb
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial of Leptin Replacement Therapy in Patients With Lipodystrophy
Status: COMPLETED
Conditions: Hypoleptinemia|Generalized Lipodystrophy|Partial Lipodystrophy|Insulin Resistance
Interventions: DRUG: Leptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness and Mechanisms of Pain Processing in Adults With Migraines
Status: COMPLETED
Conditions: Migraine
Interventions: OTHER: Mindfulness Based Stress Reduction|OTHER: Migraine/stress Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Defining the Conjunctival Staining Method: Instillation Volume and Time Course to Assess Staining With Lissamine Green
Status: COMPLETED
Conditions: Conjunctival Staining
Interventions: OTHER: 2.5/5.0/10.0 ÂµL lissamine green
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acute Uncomplicated Diverticulitis and Conservative Treatment: Accuracy of Inflammatory Indexes for Failure Prediction: Observational Prospective Cohort Study. (AUDRIP Trial)
Status: NOT_YET_RECRUITING
Conditions: Acute Uncomplicated Diverticulitis
Interventions: DIAGNOSTIC_TEST: Elevation of NLR
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Osteopathic Manipulative Treatment of Fascial Restrictions on Body Awareness, Mood, and Proprioception
Status: COMPLETED
Conditions: Segmental and Somatic Dysfunction of Other Regions (M99.09)
Interventions: OTHER: OMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety of Buprenorphine Transdermal Systems in Subjects With Chronic Nonmalignant Pain - a 28-week Extension Study
Status: COMPLETED
Conditions: Chronic Nonmalignant Pain
Interventions: DRUG: Buprenorphine transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture in Pediatrics and Adolescents With Chronic Inflammatory Bowel Diseases
Status: RECRUITING
Conditions: Morbus Crohn|Colitis, Ulcerative
Interventions: OTHER: Acupuncture|OTHER: Placebo-Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Left Ventricular Assist Device (LVAD) Specialized Centers of Clinically Orientated Research (SCCOR) Coagulation - Acute Intrinsic Pathway Antagonist (IPA)
Status: TERMINATED
Conditions: Coagulation
Interventions: DRUG: TTP889|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Comparison Between an Individual Low Tourniquet Pressure Versus a Standard Pressure During Total Knee Arthroplasty
Status: COMPLETED
Conditions: Complications; Arthroplasty
Interventions: PROCEDURE: Limb occlusion pressure (LOP)|PROCEDURE: conventional measurement method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Clinical Effect of Danirixin in Adults With Influenza
Status: COMPLETED
Conditions: Virus Diseases
Interventions: DRUG: GSK1325756 (Danirixin)|DRUG: Placebo To Match GSK1325756|DRUG: Oseltamivir Phosphate|DRUG: Placebo To Match Oseltamivir Phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Subcutaneous Infusions of ABBV-951 in Subjects With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease (PD)
Interventions: DRUG: ABBV-951
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Department of Defense Funded Pragmatic Clinical Trial
Status: ENROLLING_BY_INVITATION
Conditions: Rotator Cuff Repair|Ankle Arthroplasty or Arthrodesis|Hallux Valgus (Bunion) Resection
Interventions: DEVICE: Peripheral Nerve Stimulation|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Norepinephrine and Phenylephrine Infusion for Hemodynamic Effects in Patients With Preeclampsia
Status: RECRUITING
Conditions: Hemodynamic Instability
Interventions: DRUG: Phenylephrine|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Erector Spinae Plane Block for Percutaneous Arthrodesis of Spinal Fractures
Status: RECRUITING
Conditions: SPINAL Fracture|Pain, Postoperative
Interventions: PROCEDURE: Erector spinae plane block with naropeine [3,75 mg/mL]|PROCEDURE: ESPB with saline 0,9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine and Outcomes of Elderly Admitted to ICU After Surgery
Status: RECRUITING
Conditions: Elderly|Surgery|Intensive Care Unit|Dexmedetomidine|Overall Survival
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Analgesia Efficacy of Transversus Abdominis Plane Block and Posterior Approach Quadratus Lumborum Block
Status: COMPLETED
Conditions: Acute Post-operative Pain|Nerve Block|Prostate Cancer
Interventions: PROCEDURE: transversus abdominis plane block,
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multicenter, Randomized Study Evaluating the Value of Antitubercular Treatment During Recurent Anterior Uveitis (URBA)
Status: UNKNOWN
Conditions: Uveitis, Anterior
Interventions: DRUG: Antitubercular treatment (RIFATER ©)|DRUG: Ethambutol|DRUG: RIFINAH ©
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Renal SympAthetic DenerVation on Chronic HypErtension
Status: TERMINATED
Conditions: Uncontrolled Hypertension
Interventions: DEVICE: Celcius Thermacool Catheter or Chilli II Cooled Ablation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nilotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Nilotinib+mVPD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomedine and Ketamine in Erector Spinae Block for Postoperative Analgesia Following Mastectomy.
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Bupivacaine Hydrochloride|DRUG: Bupivacaine Hydrochloride and dexmedetomedine|DRUG: Bupivacaine Hydrochloride and ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The SeaSHeL National Prospective Cohort Study
Status: UNKNOWN
Conditions: Sensory Hearing Loss|Sensorineural Hearing Loss|Sensorineural Hearing Loss in Left Ear|Sensorineural Hearing Loss in Right Ear|Sensorineural Hearing
Interventions: OTHER: Quality of life questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neoadjuvant Chemoradiation Plus Pembrolizumab Followed By Consolidation Pembrolizumab in NSCLC
Status: TERMINATED
Conditions: Stage IIIA Non-Small Cell Lung Cancer
Interventions: DRUG: Cisplatin|DRUG: Etoposide|DRUG: Pembrolizumab|DRUG: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Thyroid Hormones in Prematures
Status: WITHDRAWN
Conditions: Transient Hypothyroxinemia of Prematurity (THOP)
Interventions: DRUG: thryoid hormone T4 + oral potassium iodide (KI) for 42 days|DRUG: D5W - 5% dextrose water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjustable Compression Wrap Versus Compression Bandage Reduce to Breast Cancer-related Lymphedema
Status: RECRUITING
Conditions: Breast Cancer Related Lymphedema|Lymphedema, Secondary|Lymphedema of Upper Arm|Breast Neoplasms
Interventions: DEVICE: Adjustable Compression Wrap|DEVICE: Compression Bandage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Islet Cell Transplantation Alone in Patients With Type 1 Diabetes Mellitus: Steroid-Free Immunosuppression
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type I
Interventions: DRUG: islets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carvedilol With Chemotherapy in Second Line Glioblastoma and Response of Circulating Tumor Cells
Status: TERMINATED
Conditions: Glioblastoma Multiforme|Glioblastoma
Interventions: DRUG: Carvedilol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating aCute heArt failuRe Decongestion Guided by Lung UltraSonography
Status: NOT_YET_RECRUITING
Conditions: Acute Heart Failure
Interventions: PROCEDURE: LUS decongestive strategy|PROCEDURE: PE decongestive strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nuclectomy
Status: UNKNOWN
Conditions: Degenerative Disc Disease|Chronic Low-back Pain
Interventions: DEVICE: All patients that meet the inclusion/exclusion criteria will receive the PerQdisc® Nucleus Replacement Device.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bifurcation ABSORB OCT Trial
Status: UNKNOWN
Conditions: Myocardial Ischemia|Ischemia|Coronary Disease|Heart Diseases|Cardiovascular Diseases|Coronary Bifurcation Lesions|Arterial Occlusive Lesions|Infarction|Myocardial Infarction|Arteriosclerosis
Interventions: DEVICE: ABSORB BVS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Esophageal Varices by Beta-Adrenergic Blockers
Status: COMPLETED
Conditions: Esophageal and Gastric Varices|Liver Cirrhosis|Portal Hypertension
Interventions: DRUG: Timolol Maleate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Routine Versus on Demand Removal of the Syndesmotic Screw
Status: COMPLETED
Conditions: Anke Fracture|Syndesmotic Injury
Interventions: PROCEDURE: Removal on demand of the syndesmotic screw|PROCEDURE: Routine removal of fhe syndesmotic screw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addressing Drug Use Stigma in Human Immunodeficiency Virus (HIV) Care and Treatment Clinics in Tanzania
Status: COMPLETED
Conditions: Drug Use Stigma in HIV Treatment Clinics
Interventions: BEHAVIORAL: Drug-use stigma reduction intervention for HIV care and treatment clinic staff
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Patients With Implantable Cardiac Devices Requiring a Nuclear Magnetic Resonance
Status: UNKNOWN
Conditions: Implantable Cardiac Device. Patients With a NMR Indication
Interventions: DEVICE: Biotronik peacemakers, implantable cardioverter-defibrillators and cardiac resynchronizers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Drotaverine Hydrochloride Versus Hyoscine-N-butylbromide for Duodenal Antimotility During Endoscopic Retrograde Cholangiopancreatography (ERCP)
Status: COMPLETED
Conditions: ERCP|Pancreatic Diseases|Bile Duct Diseases
Interventions: DRUG: Drotaverine hydrochloride|DRUG: Hyoscine-N-butylbromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial to Assess the Pharmacokinetic Characteristics of Lodivikar Tab. 5/40 mg in Healthy Adult Male Subjects
Status: COMPLETED
Conditions: Healthy Male Subjects
Interventions: DRUG: Sevikar tab. 10/40mg|DRUG: Lodivikar tab. 5/40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Peri-capsular Nerve Group (PENG) Block and Quadratus Lumborum Block for Hip Arthroplasty
Status: COMPLETED
Conditions: Post Operative Pain
Interventions: PROCEDURE: Hip surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EMD and/or Bone Substitute for the Treatment of Class II Furcations
Status: COMPLETED
Conditions: Periodontal Disease
Interventions: DRUG: EMD|DEVICE: βTCP/HA|PROCEDURE: Flap access surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First in Human Study of EMB-07 in Locally Advanced/Metastatic Solid Tumors or Relapse/Refractory Lymphoma
Status: RECRUITING
Conditions: Advanced/Metastatic Solid Tumors|Relapse/Refractory Lymphoma
Interventions: DRUG: EMB07
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CEUS For Intraoperative Spinal Cord Injury
Status: RECRUITING
Conditions: Spine Disease|Spinal Stenosis|Spinal Injury|Spinal Cord Diseases|Spinal Cord Injuries|Spinal Cord Compression|Spine Degeneration
Interventions: DEVICE: Definity Perflutren Lipid Microsphere Ultrasound Contrast
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of Novel Oral Polio Vaccine
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: nOPV2 (monovalent oral polio vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Changing Physical Activity Behavior in Individuals With Type 2 Diabetes Using Counceling and Information From Continuous Glucose Monitoring
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Effect of Physical Activity on Type II Diabetes Mellitus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Subclinical DVT Screening in Locally Advanced Bladder Cancer Patients Candidate for Radical Cystectomy.
Status: UNKNOWN
Conditions: Bladder Cancer Patients Candidate for Radical Cystectomy
Interventions: DIAGNOSTIC_TEST: Lower limb duplex & doppler
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Busulfan, Melphalan, and Fludarabine With Peri-transplant Palifermin, Followed by a T-Cell Depleted Hematopoietic Stem Cell Transplant From HLA Matched or Mismatched Related or Unrelated Donors in Patients With Advanced Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Advanced Myelodysplastic Syndromes
Interventions: DRUG: Busulfan, Melphalan, Fludarabine, Anti-Thymocyte Globulin, Palifermin, Stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Gait Training With a Walking Assist Robot on Gait Function and Balance in Elderly Adults
Status: COMPLETED
Conditions: Gait, Unsteady|Healthy
Interventions: DEVICE: Samsung Hip Assist v1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: European Trial About Effect of RimoNabant on Abdominal Obese Patients With dysLipidemia
Status: TERMINATED
Conditions: Obesity|Dyslipidemias
Interventions: DRUG: rimonabant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Microvascular Changes in OCT-angiography in Type 1 Diabetes Mellitus at the Onset of the Disease and After Optimization of Glycemic Control.
Status: RECRUITING
Conditions: Type 1 Diabetes|Diabetic Retinopathy
Interventions: DIAGNOSTIC_TEST: Optical Coherence Tomography (OCT) Angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor
Status: COMPLETED
Conditions: Brain Tumor|Central Nervous System Tumor
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: etoposide|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Talking Mats as Decision Aid for Older People Living With Mild to Moderate Dementia
Status: RECRUITING
Conditions: Mild to Moderate Dementia
Interventions: DEVICE: TalkingMats|OTHER: Usual conversation method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Debridement Invasiveness on Attachment Gain After Antiinfective Periodontal Therapy
Status: UNKNOWN
Conditions: Periodontitis|Periodontal Attachment Loss|Periodontal; Lesion
Interventions: PROCEDURE: Subgingival Debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Women With Advanced Breast Cancer Receiving Palbociclib With AI or Fulvestrant
Status: COMPLETED
Conditions: Breast Cancer|Hormone Receptor Positive Tumor|Human Epidermal Growth Factor 2 Negative Carcinoma of Breast
Interventions: DRUG: Palbociclib|DRUG: Letrozole|DRUG: Anastrozole|DRUG: Exemestane|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TACE-HAIC Combined With TKIs and Immunotherapy Versus TACE Alone for Hepatocellular Carcinoma With PVTT
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: TACE-HAIC|PROCEDURE: TACE|DRUG: Targeted therapy|DRUG: PD-1 inhibitors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Evaluation of MDT-2111 in Subjects With Symptomatic Severe Aortic Stenosis
Status: COMPLETED
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: MDT-2111 CoreValve for TAVI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benefit From the Chin Down Maneuver in the Swallowing Performance and Self-perception of Parkinson's Disease Patients
Status: COMPLETED
Conditions: Dysphagia, Oropharyngeal|Parkinson Disease|Speech Therapy|Orientation
Interventions: OTHER: chin-down posture maneuver|OTHER: Orientations about swallowing|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NEM® + KD PUR® Fish Oil Versus Placebo in Exercised-induced Joint Pain, Stiffness, & Cartilage Turnover in Healthy Men & Women
Status: COMPLETED
Conditions: Exercise-induced Joint Pain|Exercise-induced Joint Stiffness|Exercise-induced Joint Cartilage Turnover
Interventions: DIETARY_SUPPLEMENT: Move3™ (NEM® brand eggshell membrane + KD PUR® brand fish oil)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Efpeglenatide on Cardiovascular Outcomes
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Efpeglenatide (SAR439977)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of 4% Articaine Versus 0.5%Bupivacaine for Ambulatory Surgery Under Supraclavicular Block
Status: COMPLETED
Conditions: Upper Limb Surgery|Hand Surgery
Interventions: DRUG: Articaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy of IPL Treatment of Dry Eye and Ocular Rosacea
Status: COMPLETED
Conditions: Ocular Rosacea|Dry Eye
Interventions: DEVICE: Intense Pulsed Light Treatment (IPL)|PROCEDURE: Meibomian Gland Expression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Hydromorphone Hydrochloride Extended-Release Compared to Placebo in Subjects With Persistent Pain
Status: TERMINATED
Conditions: Chronic Non-Malignant Pain
Interventions: DRUG: Hydromorphone Hydrochloride Extended-Release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Dasatinib Followed by Stem Cell Transplant in Treating Older Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1
Interventions: BIOLOGICAL: Alemtuzumab|PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Dasatinib|DRUG: Daunorubicin Hydrochloride|DRUG: Dexamethasone|DRUG: Etoposide Phosphate|BIOLOGICAL: Filgrastim|DRUG: Fludarabine Phosphate|PROCEDURE: In Vitro-Treated Peripheral Blood Stem Cell Transplantation|OTHER: Laboratory Biomarker Analysis|DRUG: Leucovorin Calcium|DRUG: Melphalan|DRUG: Mercaptopurine|DRUG: Methotrexate|BIOLOGICAL: Pegfilgrastim|OTHER: Pharmacological Study|DRUG: Tacrolimus|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Axicabtagene Ciloleucel in Combination With Utomilumab in Adults With Refractory Large B-cell Lymphoma
Status: TERMINATED
Conditions: Relapsed/Refractory Large B-cell Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|BIOLOGICAL: Axicabtagene Ciloleucel|BIOLOGICAL: Utomilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Heart Failure With Preserved Ejection Fraction - COngestion eValuation
Status: RECRUITING
Conditions: Chronic Heart Failure|Preserved Ejection Fraction
Interventions: PROCEDURE: Clinical examination centered on congestion|PROCEDURE: Cardiac, pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography|PROCEDURE: Blood and urine sample retrieved for biological assessment and biobanking|OTHER: Telephone follow-up|BEHAVIORAL: Kansas City Cardiomyopathy Questionnaire (KCCQ)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Feasibility and Reproducibility of Barostat Assessments of Colorectal Sensation During Colorectal Distention and Its Pharmacological Modulation Using Octreotide
Status: COMPLETED
Conditions: Irritable Bowel Syndrome (IBS)
Interventions: DRUG: SMS995|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Comparative Efficacy of Two Different Dual-task Balance Interventions
Status: COMPLETED
Conditions: Stroke|Healthy Older Adults
Interventions: DEVICE: motor-cognitive dual-task training|DEVICE: cognitive dual-task training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Unblinded Study of TAK-438 (20 mg) for Prevention of Recurrence of Gastric or Duodenal Ulcer During Long-Term Low-Dose Aspirin Therapy
Status: COMPLETED
Conditions: Gastric Ulcer|Duodenal Ulcer
Interventions: DRUG: TAK-438
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Health Economic Evaluation of Using N-Terminal Pro Brain Natriuretic Peptide (NT-Pro BNP) in Acute Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DIAGNOSTIC_TEST: NT-Pro BNP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase IIb Study Evaluating Immunogenic Chemotherapy Combined With Ipilimumab and Nivolumab in Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Hormone Receptor Positive Tumor|Metastatic Breast Cancer
Interventions: DRUG: Ipilimumab|DRUG: Nivolumab|DRUG: Pegylated liposomal doxorubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Health and Reducing Disability of Depressed Elderly With Chronic Conditions Through Qigong Exercise
Status: COMPLETED
Conditions: Chronic Disease|Depressive Symptoms
Interventions: BEHAVIORAL: Qigong Training|BEHAVIORAL: Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CAR T Cells in Mesothelin Expressing Cancers
Status: COMPLETED
Conditions: Lung Adenocarcinoma|Ovarian Cancer|Peritoneal Carcinoma|Fallopian Tube Cancer|Mesotheliomas Pleural|Mesothelioma Peritoneum
Interventions: BIOLOGICAL: huCART-meso cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of the Tablet Formulation of Lopinavir/r as Standard and Increased Dosage During Pregnancy
Status: COMPLETED
Conditions: HIV Infections|Pregnancy
Interventions: DRUG: Lopinavir / ritonavir|DRUG: Lopinavir/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Clinical Evaluation of the MINI TREK RX 1.20 mm Coronary Dilatation Catheter in Stenotic Lesions
Status: COMPLETED
Conditions: Ischemic Heart Disease|Coronary Artery Stenosis|Chronic Coronary Total Occlusion|Coronary Bypass Graft Stenosis
Interventions: DEVICE: MINI TREK RX 1.20 mm Coronary Dilatation Catheter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: High-dose Dual Therapy and Minocycline-cotaining Quadruple Therapy for Helicobacter Pylori Infection
Status: RECRUITING
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Vonoprazan|DRUG: Amoxicillin|DRUG: Bismuth Potassium Citrate|DRUG: Minocycline,Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preeclampsia Intervention Netherlands
Status: NOT_YET_RECRUITING
Conditions: Pre-Eclampsia Onset Less Than 37 Weeks|Pre-Eclampsia|Pre-Eclampsia; Complicating Pregnancy|Pre-Eclampsia as Antepartum Condition|Pre-eclampsia or Eclampsia With Pre-existing Hypertension|Pre-Eclampsia; Affecting Fetus|HELLP Syndrome Complicating Pregnancy|HELLP Syndrome|HELLP
Interventions: DRUG: Metformin Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Incentives for Stressful Medical Procedures
Status: RECRUITING
Conditions: Healthy
Interventions: BEHAVIORAL: Child life standard of care|BEHAVIORAL: Child life standard of care + incentives provided with conditional agreement.|BEHAVIORAL: Child life standard of care + incentive provided unconditionally.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Evaluation of Monolithic Zirconia FPDs
Status: COMPLETED
Conditions: Dental Materials
Interventions: DRUG: Monolithic zirconia|OTHER: Veneered zirconia|OTHER: Metal-ceramic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Broad Spectrum HPV (Human Papillomavirus) Vaccine in 16 to 26 Year Old Women (V505-001)
Status: COMPLETED
Conditions: Cervical Cancer|Vulvar Cancer|Vaginal Cancer|Genital Warts|Human Papillomavirus Infection
Interventions: BIOLOGICAL: Comparator: V505 formulation 1|DRUG: Comparator: V505 formulation 2|DRUG: Comparator: V505 formulation 2|BIOLOGICAL: Comparator: V505 formulation 3|BIOLOGICAL: Comparator: Quadrivalent Human Papillomavirus (Types 6, 11, 16, 18) Recombinant|BIOLOGICAL: Comparator: Placebo (unspecified)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of Clemastine Fumarate as a Remyelinating Agent in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Clemastine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Preventive Effect of Escitalopram on Depression and Related Emotional Disorders in Acute Stroke Patients
Status: UNKNOWN
Conditions: Depression
Interventions: DRUG: Escitalopram|DRUG: sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Improving Osteoporosis Care in High-Risk Home Health Patients
Status: COMPLETED
Conditions: Patient Compliance|Communication|Osteoporosis|Fractures, Bone
Interventions: BEHAVIORAL: nurse-patient communication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy in Treating Patients With Colorectal Cancer and Resectable Metastases
Status: COMPLETED
Conditions: Colorectal Cancer|Metastatic Cancer|Chemotherapy
Interventions: DRUG: oxaliplatin, folinic acid, fluorouracil|DRUG: oxaliplatin, irinotecan, folinic acid, fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study of Bevacizumab and Paclitaxel in Combination With Atezolizumab as a Treatment for Locally Advanced Unresectable or Metastatic Hormone Receptor-positive HER2 Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Paclitaxel + bevacizumab therapy|DRUG: Paclitaxel + bevacizumab + atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D for COVID-19 Trial
Status: COMPLETED
Conditions: COVID-19
Interventions: DIETARY_SUPPLEMENT: vitamin D|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, RCT Study of the Clinical Efficacy of Robotic and Laparoscopic Gastrectomy in Neoadjuvant Gastric Cancer
Status: RECRUITING
Conditions: Gastric Cancer Stage II|Gastric Cancer Stage III
Interventions: PROCEDURE: Robotic radical gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Dietary Inflammatory Potential on Breast Cancer Risk
Status: NOT_YET_RECRUITING
Conditions: Breast Atypical Ductal Hyperplasia|Breast Atypical Lobular Hyperplasia|Breast Carcinoma|Breast Lobular Carcinoma In Situ|Breast Sclerosing Adenosis
Interventions: PROCEDURE: Follow-Up|PROCEDURE: Physical Examination|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose-finding and Dose Expansion Study of OSE-279 in Subjects With Advanced Solid Tumors or Lymphomas
Status: RECRUITING
Conditions: Solid Advanced Tumor|Lymphoma
Interventions: DRUG: OSE-279 100mg|DRUG: OSE-279 300mg|DRUG: OSE-279 500mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addressing Asymptomatic Plasmodium Reservoirs to Accelerate Malaria Elimination and Eradication in Rwanda.
Status: NOT_YET_RECRUITING
Conditions: Malaria,Falciparum
Interventions: DIETARY_SUPPLEMENT: Artemisia afra or Annua 10g oral infusion/tea per day for 14 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Dose-response Effects of a Defined Volume of Physical Exercise on the Change of Peripheral Biomarkers, Clinical Response and Brain Connectivity in Parkinson's Disease: a Prospective, Observational, Cohort Pilot Study
Status: ENROLLING_BY_INVITATION
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: Aerobic exercise
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: eHealth Diet and Physical Activity Program for the Improvement of Health in Rural Latino Cancer Survivors
Status: TERMINATED
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: BEHAVIORAL: Health Education|OTHER: Physical Activity|OTHER: Health Promotion and Education: Text Messages|OTHER: Health Promotion and Education: Web Site|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Randomized Controlled Trial to Assess Effects of Lacosamide on Sleep and Wake in Adults With Focal Epilepsy
Status: COMPLETED
Conditions: Partial Epilepsy
Interventions: DRUG: Lacosamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence of Headache Following an Unintentional Dural Puncture
Status: COMPLETED
Conditions: Postdural Puncture Headache|Post-Lumbar Puncture Headache|Cerebrospinal Fluid Leaks
Interventions: DRUG: Morphine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of LCZ696 in Comparison to Olmesartan in Elderly Patients With Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Olmesartan|DRUG: Placebo|DRUG: LCZ696
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Protocol for the Evaluation of Dario™ BGMS Performance at Elevated Altitude
Status: COMPLETED
Conditions: Diabetes
Interventions: DEVICE: Dario Blood Glucose Monitoring System|DEVICE: YSI Analyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER