pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of a Lifestyle and Sleep Intervention in Non-exercising Adults
Status: RECRUITING
Conditions: Inactivity, Physical|Lifestyle Risk Reduction
Interventions: BEHAVIORAL: Lifestyle intervention (physical activity and diet)|BEHAVIORAL: Lifestyle (physical activity and diet) and Sleep intervention|BEHAVIORAL: Health education intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety Study of Inhaled Insulin: An Up to Four-Year Extension of Therapy in Subjects With Type 1 or Type 2 Diabetes Mellitus
Status: TERMINATED
Conditions: Diabetes Mellitus
Interventions: DRUG: Exubera® (inhaled insulin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality (VR) Self-Hypnosis Software
Status: NOT_YET_RECRUITING
Conditions: Musculoskeletal Pain|Neuropathic Pain|Neuralgia
Interventions: DEVICE: Virtual Reality headset
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Postbiotic as Adjunct Treatment for Vaginal Candidiasis
Status: RECRUITING
Conditions: Vaginal Candidiasis
Interventions: DEVICE: Postbiotic|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pulmozyme for Sjogren's Associated Cough
Status: WITHDRAWN
Conditions: Sjogren's Syndrome|Cough
Interventions: DRUG: Dornase alfa|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Autologous Stem Cell Transplant (ASCT) With Intravenous Busulfan and Melphalan as Conditioning Regimen
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Intravenous busulfan and melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Recruitment Maneuver During Intraoperative Period
Status: COMPLETED
Conditions: Laparoscopic Hysterectomy
Interventions: PROCEDURE: Alveolar Recruitment maneuver (ARM) +PEEP|PROCEDURE: PEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Diaphragmatic Ultrasound Associated With RSBI Predict Weaning Issue: the Rapid Shallow Diaphragmatic Index (RSDI)
Status: COMPLETED
Conditions: Mechanical Ventilation|Mechanical Ventilator Weaning|Extubation|Diaphragm Ultrasound
Interventions: DIAGNOSTIC_TEST: assess diaphragmatic displacement (DD) using ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Leukotriene Receptor Antagonist Montelukast in the Treatment of Non-alcoholic Steatohepatitis
Status: COMPLETED
Conditions: Steatohepatitis, Nonalcoholic
Interventions: DRUG: Control group|DRUG: Montelukast group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Spirulina on Serum Hyaluronic Acid in Beta Thalassemic Children With Hepatitis C
Status: COMPLETED
Conditions: Beta Thalassemia Major
Interventions: DIETARY_SUPPLEMENT: Spirulina
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Spectral Domain Optical Coherence Tomography Imaging of the Eyes of Neonates
Status: COMPLETED
Conditions: Retinal Diseases|Optic Nerve Diseases
Interventions: OTHER: Observational: to better characterize the retina and optic nerve in newborns using spectral domain optical coherence tomography (s-oct).|PROCEDURE: OCT imaging.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Sativex® and Gentamicin for Optimized Pharmagological Treatment in Older Patients (CanPan)
Status: UNKNOWN
Conditions: Malnutrition|Anorexia|Cannabis|Aging|Emergency Service, Hospital|Renal Function|Pharmacokinetics
Interventions: DRUG: Sativex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Influence of the Expression of the Calcium-sensitive Receptor (CaSR) by Monocytes in the Synovial Liquid on Structural Alterations in Patients Diagnosed With Rheumatoid Arthritis in the Previous Two Years
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: BIOLOGICAL: blood
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Cerebral Vascular Reserve Using Pharmacological Testing With Acetazolamide: A Non-Inferiority Study of PET Method Compared to Conventional Reference Scintigraphy
Status: NOT_YET_RECRUITING
Conditions: Cerebrovascular Circulation
Interventions: DIAGNOSTIC_TEST: PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Zirconia-based Primary Anterior Crowns With Retention Grooves Versus Without Retention Grooves
Status: RECRUITING
Conditions: Dental Caries|Tooth Decay
Interventions: PROCEDURE: Zirconia-based primary anterior crowns with retention grooves|PROCEDURE: Zirconia-based primary anterior crowns without retention grooves
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Autologous Peripheral Blood Stem Cell Mobilization for PEG-G-CSF
Status: NOT_YET_RECRUITING
Conditions: Granulocyte Colony-stimulating Factor|Stem Cell Mobilization
Interventions: DRUG: PEG-rhG-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Parallel-Arm, Placebo and Active Controlled Dose-Ranging Study of the Efficacy and Safety of Multiple Doses of Tapentadol IR for Postoperative Pain Following Bunionectomy Surgery
Status: COMPLETED
Conditions: Pain|Postoperative Pain
Interventions: DRUG: tapentadol HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b Study Evaluating RESTEN-MP in Subjects With Focal de Novo Stenosis
Status: TERMINATED
Conditions: Coronary Artery Disease|Coronary Stent Restenosis
Interventions: DRUG: RESTEN-MP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Application of mRNA Immunotherapy Technology in Hepatitis B Virus-related Refractory Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Liver Cancer|Hepatocellular Carcinoma
Interventions: BIOLOGICAL: HBV mRNA vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of an α2-Adrenoceptor Antagonist (Yohimbine) on Dynamic Autoregulation in the Human Middle Cerebral Artery and Ophthalmic Artery
Status: COMPLETED
Conditions: Blood Flow Velocity|Autoregulation|Ocular Physiology
Interventions: DRUG: Yohimbine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: High-intensity Inspiratory Muscle Training as a Pre-cardiac Rehabilitation in Heart Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Bypass Graft|CABG
Interventions: DEVICE: IMT|DEVICE: Sham-IMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PEACe: Ivy, Thyme and Cisti Extract (Phytus) Efficacy in Acute Cough
Status: COMPLETED
Conditions: Cough|Common Cold
Interventions: DRUG: Phytus (Cisti, Thyme and Ivy Leaves)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Checkpoint Inhibitor Combinations Therapy as First Line for Inoperable Lung Cancer Via IT
Status: RECRUITING
Conditions: Lung Cancer|Inoperable Disease
Interventions: DRUG: ipilimumab+pembrolizumab or ipilimumab+durvalumab, idarubicin, bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of BIS Monitorization to Intraoperative Anesthetic Consumption During Coronary Artery Surgery
Status: COMPLETED
Conditions: Unconscious State
Interventions: DEVICE: BIS|DRUG: Desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Depletion of Myeloid Derived Suppressor Cells to Enhance Anti PD-1 Therapy
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer Stage IIIB
Interventions: BIOLOGICAL: Nivolumab|DRUG: Nivolumab+Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Innovative Teaching Solutions to Improve the Outcomes of Home Caregivers
Status: ENROLLING_BY_INVITATION
Conditions: Medication Errors and Other Product Use Errors and Issues
Interventions: OTHER: 360 videos|OTHER: VR|OTHER: AR|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Attitudes Toward Food During a Weight Loss Intervention
Status: COMPLETED
Conditions: Obesity|Weight Loss|Overweight and Obesity|Overweight or Obesity|Eating Behavior|Food Habits|Eating Disorder Symptom
Interventions: BEHAVIORAL: Noom Healthy Weight; mobile behavior change program for weight loss.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Normative Biomechanical Measures of Reaching in Able-Bodied Adults
Status: COMPLETED
Conditions: Individuals With Functional Limitations Which May Impact Their Forward Reach
Interventions: OTHER: Modified Functional Reach and Functional Reach
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Immunogenicity and Reactogenicity of INFANRIX™ HEXA and HEXAVAC™ Vaccines as a Primary Vaccination Course
Status: COMPLETED
Conditions: Hepatitis B|Poliomyelitis|Diphtheria|Acellular Pertussis|Tetanus|Haemophilus Influenzae Type b
Interventions: BIOLOGICAL: DTPa-HBV-IPV/Hib Vaccine (INFANRIX™ HEXA)|BIOLOGICAL: DTPa-HBV-IPV-Hib vaccine (HEXAVAC™)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Trial to Find the Safe Dose for BI 905681 in Patients With Incurable Tumours or Tumours That Have Spread
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: BI 905681
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RAMPS VS SRPS for Pancreatic Body and Tail Adenocarcinoma
Status: NOT_YET_RECRUITING
Conditions: Radical Antegrade Modular Pancreatosplenectomy
Interventions: PROCEDURE: Radical antegrade modular pancreatosplenectomy|PROCEDURE: Standard retrograde pancreatosplenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: GATT Versus Canaloplasty (GVC)
Status: NOT_YET_RECRUITING
Conditions: Glaucoma, Open-Angle
Interventions: PROCEDURE: canaloplasty|PROCEDURE: Gonioscopy-assisted Transluminal Trabeculotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Pharmacogenetics of Optimal Warfarin Therapy in Chinese Patients After Heart Valve Replacement.
Status: UNKNOWN
Conditions: Heart Valve Disease|Older Than 18-years-old|Without Any Liver or Kidney Diseases
Interventions: GENETIC: CYP2C9;VKORC1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Tolerability and Early Efficacy of hLF1-11 in Patients With Bacteremia Due to S. Epidermidis
Status: WITHDRAWN
Conditions: Staphylococcal Infections|Bacteremia
Interventions: DRUG: human lactoferrin peptide 1-11
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does Routine Submucosal Injection Improve Complete Resection of 4-20 mm Neoplastic Colorectal Polyps?
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: PROCEDURE: Cold snare polypectomy in conjunction with a submucosal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Investigation of the Effectiveness of Wii-Based Exercise Play Therapy in Knee Osteoarthritis Rehabilitation
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Structured Proprioception and Closed Kinetic Chain Exercises Group|OTHER: Wii Based Balance Training Program Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of Attention and Its Relationship With Emotions in Children and Adolescents
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DEVICE: a serious mobile device-based game prototype (Save the Muse Home)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Study Using Trastuzumab or Trastuzumab With Pertuzumab in Gastric or Gastroesophageal Junction Adenocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Neoplasm of Stomach|Malignant Neoplasm of Cardio-esophageal Junction of Stomach|Epidermal Growth Factor Receptor (EGFR) Protein Overexpression
Interventions: DRUG: Cisplatin|DRUG: 5-fluorouracil or Capecitabine|DRUG: Trastuzumab|DRUG: Pertuzumab|PROCEDURE: gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: One-time Abutment Placement Versus 4 Times Abutment Removal Around Dental Implants
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Implant|Prosthetic Abutment
Interventions: PROCEDURE: Abutment removal|PROCEDURE: Placement of definitive abutment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Long-term Administration Trial of Brexpiprazole Once-weekly (QW) Formulation in Patients With Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: OPC-34712FUM/ Brexpiprazole fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fasting Study of Terbinafine Hydrochloride Tablets 250 mg and Lamisil® Tablets 250 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Terbinafine Hydrochloride Tablets 250 mg|DRUG: Lamisil® Tablets 250 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: 177Lu-DOTA-TLX591 Safety, Biodistribution and Dosimetry Study
Status: COMPLETED
Conditions: Metastatic Prostate Cancer
Interventions: BIOLOGICAL: 177Lu-DOTA-TLX591
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Flamboyant 200/12 Association in the Treatment of Adults With Severe Asthma
Status: UNKNOWN
Conditions: Asthma
Interventions: DRUG: Flamboyant 200/12|DRUG: Budesonide / Formoterol 400/12|OTHER: Flamboyant 200/12 Placebo|OTHER: Budesonide / Formoterol 400/12 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Altitudes for Caregivers
Status: RECRUITING
Conditions: Care Burden|Care Giving Burden|Caregiver Burnout|Caregiver Stress|Caregiver Wellbeing|Support, Family
Interventions: DEVICE: Altitudes USA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD)
Status: COMPLETED
Conditions: Chronic Beryllium Disease (CBD)|Beryllium Sensitization (BeS)
Interventions: PROCEDURE: Blood draw|PROCEDURE: bronchoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Factors Affecting the Results of Treatment of Patients With Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer|Colon Cancer|Rectal Cancer|Colorectal Adenocarcinoma|Colorectal Neoplasms Malignant|Rectal Adenocarcinoma
Interventions: PROCEDURE: Right hemicolectomy|PROCEDURE: Left hemicolectomy|PROCEDURE: Sigmoid colon resection|PROCEDURE: Anterior resection of the rectum|PROCEDURE: Low anterior resection of the rectum|PROCEDURE: Abdominoperineal resection|PROCEDURE: Total Colectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combined Qigong and Acupressure for Improving Chemotherapy-induced Peripheral Neuropathy
Status: RECRUITING
Conditions: Cancer|Chemotherapy-induced Peripheral Neuropathy
Interventions: BEHAVIORAL: Combined qigong Baduanjin and self-administered acupressure|BEHAVIORAL: Wait-list Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Collection of Tissue & Blood From Patients w/ Benign & Malignant Tumors of the Soft Tissue & Gastrointestinal Tract
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Cancer|Bile Duct Neoplasms|Gastric Cancer|Liver Cancer|Melanoma|Pancreatic Cancer|Sarcoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Continuous Soluble Ferric Pyrophosphate (SFP) Iron Delivery Via Dialysate in Hemodialysis Patients (CRUISE 2)
Status: COMPLETED
Conditions: Renal Failure Chronic Requiring Hemodialysis
Interventions: DRUG: Soluble Ferric Pyrophosphate (SFP)|DEVICE: Standard dialysate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effectiveness of Exercise and Vagus Therapy in Healthy Individuals
Status: UNKNOWN
Conditions: Healthy|Activity, Motor|Sleep|Stress, Physiological|Fatigue
Interventions: OTHER: Exercise|OTHER: Vagus Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tracking Mood: The Effects of Daily Mood Tracking VAS on Alcohol Consumption in Adult Heavy Drinkers
Status: NOT_YET_RECRUITING
Conditions: Alcohol Abuse|Alcohol Drinking|Alcohol Use Disorder|Alcohol Dependence|Alcohol Intoxication
Interventions: BEHAVIORAL: Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Outcomes of Biceps Tenodesis or Labral Repair for Treatment of Type 2 Superior Labrum Anterior and Posterior Lesions
Status: COMPLETED
Conditions: Type 2 SLAP Lesions
Interventions: PROCEDURE: Biceps tenodesis|PROCEDURE: Labral repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigational Study to Evaluate Experimental Medication SYHX1901 Tablets With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Effects, Drug Side
Interventions: DRUG: Placebo|DRUG: SYHX1901
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Male Hormonal Contraceptive Development-ACY-5
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Acyline|DRUG: Testosterone Gel|DRUG: Depo-Medroxyprogesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: S-1 or Tegafur-Uracil in Treating Patients With Previously Treated Stage III or Stage IV Head and Neck Cancer
Status: UNKNOWN
Conditions: Head and Neck Cancer
Interventions: DRUG: tegafur-gimeracil-oteracil potassium|DRUG: tegafur-uracil|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Lenvatinib Plus PD-1 Antibody Versus Lenvtinib Alone for Advanced HCC
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Lenvatinib|DRUG: PD-1 antibody|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Oral Cold Water Spray Application on Thirst Severity in Patients Undergoing Spinal Surgery
Status: RECRUITING
Conditions: Thirst
Interventions: OTHER: Oral cold spray (tap water)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Comparative Study Between Mechanical and a Viscoelastic Disc Prosthesis in the Lumbar Spine
Status: UNKNOWN
Conditions: Degenerative Disc Disease|Discogenic Low Back Pain
Interventions: PROCEDURE: Device: ZACK|PROCEDURE: Device: ORBIT|PROCEDURE: Device: SASCA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pocket Versus Tunnel ICRS for Treatment of Keratoconus
Status: COMPLETED
Conditions: Keratoconus
Interventions: PROCEDURE: Intrastromal corneal ring segment implantation (Pocket)|PROCEDURE: Intrastromal corneal ring segment implantation (Tunnel)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endometrial Cancer Patientes MMR Deficient Comparing Chemotherapy vs Dostarlimab in First Line
Status: RECRUITING
Conditions: Endometrial Cancer
Interventions: DRUG: Carboplatin-Paclitaxel|DRUG: Dostarlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PEG-ASP+Gemoxd vs. PEG-ASP+CHOP as First-line Chemotherapy to Treatment NK/T-cell Lymphoma With Early Stage
Status: UNKNOWN
Conditions: Lymphoma
Interventions: DRUG: pegaspargase|DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Dexamethasone|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone|RADIATION: IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of C-TIL052A Cell Therapy in Advanced Cervical Cancer
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: BIOLOGICAL: Autologous Tumor Infiltrating Lymphocytes (C-TIL052A) Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Heavy Levobupivacaine With Enantiomeric Excess of 50% and Heavy Racemic Bupivacaine.
Status: WITHDRAWN
Conditions: Fracture of Lower Limb
Interventions: DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Exploratory Study of the Efficacy and Safety of Juvista 250ng When Administered Following Excision of Ear Lobe Keloids
Status: COMPLETED
Conditions: Keloid
Interventions: DRUG: Avotermin (Juvista)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Mechanism of NIV in Relieving Dyspnea After Exercise in Patients With Stable Severe COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Dyspnea
Interventions: DEVICE: noninvasive ventilation|DEVICE: oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acceptable Hemodynamic Changes in Dexmedetomidine for Single Intravenous Bolus Injection
Status: UNKNOWN
Conditions: Delirium|Postoperative Complications|Pathologic Processes|Neurocognitive Disorders|Mental Disorders|Dexmedetomidine|Hypnotics and Sedatives|Physiological Effects of Drugs|Analgesics|Molecular Mechanisms of Pharmacological Action
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Skin Care Applied With Two Different Oils on Skin Integrity and Growth Parameters in Premature Babies
Status: UNKNOWN
Conditions: Premature Birth|Skin Care
Interventions: OTHER: skin care with sunflower oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioequivalence Study to Compare Metformin / Vildagliptin (850 mg/50 mg) Versus Galvumet®
Status: COMPLETED
Conditions: Fed Conditions
Interventions: DRUG: Metformin / Vildagliptin Film Coated Tablets (850 mg / 50 mg)|DRUG: Galvumet® Film Coated Tablets (850 mg / 50 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluate and Understand Preferences and Representations in Families of Patients With Regard to High-throughput Sequencing Technology for Diagnostic Purposes
Status: COMPLETED
Conditions: Rare Diseases
Interventions: OTHER: quantitive study: 500 patients likely to be candidates for HTS|OTHER: qualitative study: 30 patients who have benefited from HTS
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Negative Valence Brain Targets and Predictors of Anxiety and Depression Treatment
Status: COMPLETED
Conditions: Internalizing Psychopathologies (IPs) Depression and Anxiety
Interventions: DRUG: SSRI|BEHAVIORAL: CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-030)
Status: COMPLETED
Conditions: Chronic Cough
Interventions: DRUG: Placebo|DRUG: Gefapixant 15 mg BID|DRUG: Gefapixant 45 mg BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Systemic Exposure, Systemic Pharmacodynamics and Safety and Tolerability of FluticasoneFuroate, Umeclidinium and Vilanterol in Healthy Subjects
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: UMEC /VI|DRUG: UMEC|DRUG: VI|DRUG: FF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Efficacy of a Functional Meta-Cognitive Intervention to Improve Human Factors of Professional Drivers
Status: COMPLETED
Conditions: Human Risk Factors|Driving Behavior|Meta-cognition
Interventions: BEHAVIORAL: Functional Meta-Cognitive Intervention|BEHAVIORAL: The employer's training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Light in Frail Elderly - the Effect of a Dynamic Light for Sleep and Circadian Rhythm
Status: SUSPENDED
Conditions: Aged|Circadian Rhythm|Cognition|Fatigue|Humans|Light|Melatonin|Sleep|Biocentric|Frailty|Karolinska Sleepiness Score|Inflammation
Interventions: OTHER: Biocentric light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Pimavanserin for the Treatment of Agitation and Aggression in Subjects With Alzheimer's Disease
Status: COMPLETED
Conditions: Agitation and Aggression in Alzheimer's Disease
Interventions: DRUG: Pimavanserin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The JenaValve ALIGN-AR Pivotal Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Regurgitation|Aortic Valve Insufficiency|Aortic Insufficiency|Aortic Valve Disease
Interventions: DEVICE: JenaValve Trilogy Heart Valve System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BBI503 in Combination With Selected Anti-Cancer Therapeutics in Adult Patients With Advanced Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: BBI503|DRUG: Capecitabine|DRUG: Doxorubicin|DRUG: Nivolumab|DRUG: Pembrolizumab|DRUG: Paclitaxel|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess Safety/Efficacy of ELAD in Subjects w/ Severe Acute Alcoholic Hepatitis (sAAH) and Lille Score Failure
Status: TERMINATED
Conditions: Severe Acute Alcoholic Hepatitis
Interventions: BIOLOGICAL: ELAD|OTHER: Standard of Care treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observation of Atelectasis Using Lung Ultrasonography in Children Undergoing General Anesthesia: the Cohort Study for Evaluation of the Relationship Between the Incidence and Severity of Upper Respiratory Tract Infection and the Magnitude of Anesthesia-induced Atelectasis
Status: COMPLETED
Conditions: Surgery
Interventions: OTHER: questionnaire about the severity of their symptoms of upper respiratory tract infection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Therapeutic Effect of Dau-Di-Wu-Gong in Patient With Ankle Fracture
Status: COMPLETED
Conditions: Ankle Fractures
Interventions: DRUG: Helminthostachys zeylanica(L.)Hook|DRUG: Starch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Drug-drug Interaction Study of Dovitinib (TKI258) in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors, Excluding Breast Cancer
Interventions: DRUG: caffeine|DRUG: diclofenac|DRUG: omeprazole|DRUG: midazolam|DRUG: TKI258
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vebreltinib Plus PLB1004 as the First-line Therapy for Patients With EGFRm+/MET+ Locally Advanced or Metastatic NSCLC.
Status: RECRUITING
Conditions: Non-Small-Cell Lung Cancer
Interventions: DRUG: Vebreltinib|DRUG: Osimertinib|DRUG: PLB1004
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Steroid-free Treatment for Standard-Risk aGVHD (BMT CTN 1501)
Status: COMPLETED
Conditions: Acute GVHD
Interventions: DRUG: Sirolimus|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2, Open-label Trial of Consolidation Nivolumab After Concurrent Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Nasopharyngeal Carcinoma
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tzanck Smear With Methylene Blue Stain for Herpes
Status: UNKNOWN
Conditions: Herpes Simplex|Herpes Zoster|Varicella Zoster
Interventions: DIAGNOSTIC_TEST: Methylene blue|DIAGNOSTIC_TEST: Giemsa stain
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Robotic TruST-Postural Intervention for Children With Cerebral Palsy
Status: RECRUITING
Conditions: Cerebral Palsy
Interventions: DEVICE: Robotic Trunk-Support-Trainer (TruST)|DEVICE: Static Trunk Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasonographic Assessement Of Diaphragm In Neuromuscular Diseases In Pediatric Patients
Status: UNKNOWN
Conditions: Ultrasonographic Assessement Of Diaphragm In Neuromuscular Diseases In Pediatric Patients
Interventions: DEVICE: ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Motivation to Exercise
Status: COMPLETED
Conditions: Overweight|Obesity|Physical Activity
Interventions: OTHER: High Dose Exercise (300 kcal)|OTHER: Low Dose Exercise (150 kcal)|OTHER: No Exercise (0 kcal)|OTHER: Sedentary Option
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of LIV001 in Healthy Subjects and Those With Mild-to-Moderate Active Ulcerative Colitis (UC)
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: LIV001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Clinical Safety and Performance of the CorNeat KPro for Treatment of Corneal Blindness
Status: RECRUITING
Conditions: Corneal Disease|Corneal Opacity|Corneal Injuries
Interventions: DEVICE: CorNeat KPro
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Safety and Efficacy Trial of Beclomethasone Dipropionate - Hydrofluoroalkane (BDP-HFA) 320 mcg in Allergic Rhinitis
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial
Interventions: DRUG: Beclomethasone dipropionate|DRUG: Placebo Nasal Aerosol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Practice Guideline for Neonatal Extravasation Injury
Status: COMPLETED
Conditions: Extravasation Injury
Interventions: OTHER: Clinical practice guideline for prevention and management of extravasation injury
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Macular Buckle Versus Vitrectomy on Macular Hole and Macular Detachment in Highly Myopic Eyes
Status: COMPLETED
Conditions: Macular Holes|High Myopia|Macular Detachment
Interventions: PROCEDURE: Buckle|PROCEDURE: Vitrectomy|OTHER: Limbal paracentesis|OTHER: Gas injection|OTHER: Peeling internal limiting membrane|OTHER: Gas tamponade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Suprapubic Versus Transurethral Catheterization After Rectal Resection With Low Anastomosis for Cancer in Males
Status: COMPLETED
Conditions: Infection|Cancer
Interventions: DEVICE: suprapubic catheterization|DEVICE: transurethral catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Proficiency Based Robotics Training Curriculum: Skill Acquisition & Transferability of Skills to Live Porcine Models
Status: COMPLETED
Conditions: Medical Students Naive to Surgical Robotics
Interventions: BEHAVIORAL: Surgical Simulation Practice Modules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Identification of Host Factors of Norovirus Infections in Mini-Gut Model
Status: UNKNOWN
Conditions: Gastrointestinal Infection
Interventions: PROCEDURE: Duodenal biopsy|PROCEDURE: Saliva
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bone Marrow Aspirate Concentration in Posterior Cervical Fusion
Status: TERMINATED
Conditions: Cervical Myelopathy|Radiculopathy
Interventions: BIOLOGICAL: locally harvested autograft, demineralized bone matrix, and cadaveric allograft|BIOLOGICAL: Bone Marrow Aspirate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Clinical Trial Comparing Open to Mini-Open Rotator Cuff Repair for Full-Thickness Rotator Cuff Tears.
Status: COMPLETED
Conditions: Rotator Cuff Tear
Interventions: PROCEDURE: Open acromioplasty with rotator cuff repair|PROCEDURE: Arthroscopic acromioplasty with mini-open repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ECPR for Refractory Out-Of-Hospital Cardiac Arrest
Status: COMPLETED
Conditions: Cardiac Arrest|Heart Arrest|Sudden Cardiac Arrest|Cardiopulmonary Arrest|Death, Sudden, Cardiac|Cardiopulmonary Resuscitation|CPR|Extracorporeal Cardiopulmonary Resuscitation|Extracorporeal Membrane Oxygenation
Interventions: DEVICE: Expedited Transport With Mechanical CPR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comprehensive Genomic Profiling and Next Generation Functional Drug Screening for Patients With Aggressive Haematological Malignancies
Status: RECRUITING
Conditions: Advanced Lymphoma|Refractory Lymphoma|Refractory Leukemia|Refractory Acute Myeloid Leukemia|Refractory T-Cell Lymphoma
Interventions: DIAGNOSTIC_TEST: Next generation functional drug screening|DIAGNOSTIC_TEST: Comprehensive genomic profiling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Renal Considerations in the Heat Stress Recommendations
Status: COMPLETED
Conditions: Hot Weather; Adverse Effect|Kidney Dysfunction|Kidney Injury|Hyperthermia|Dehydration
Interventions: OTHER: 23.0°C WBGT - Fixed Work Rate|OTHER: 25.5°C WBGT - Fixed Work Rate|OTHER: 27.5°C WBGT - Fixed Work Rate|OTHER: 28.5°C WBGT - Fixed Work Rate|OTHER: 35.5°C WBGT - Fixed Work Rate|OTHER: 26.0°C WBGT - Fixed work-to-rest ratio|OTHER: 30.5°C WBGT - Fixed work-to-rest ratio|OTHER: 30.5°C WBGT - Fixed work-to-rest ratio (high intensity)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: AVN of Weight-Bearing Joints In Patients With Hematologic Malignancies Treated With Dexamethasone Or Prednisone
Status: COMPLETED
Conditions: Avascular Necrosis|Acute Lymphoblastic Leukemia
Interventions: PROCEDURE: MRI|OTHER: Functional Status and Symptom Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the IGF-1R Inhibitor AXL1717 in Combination With Gemcitabine HCL and Carboplatin to Treat Non-small-cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: AXL1717
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conventional Radiofrequency, Pulse Radiofrequency, and TENS for Lumbar Facet Joint Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DEVICE: TENS|PROCEDURE: Conventional or Pulse Radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Learning Effect in the Measurement of Circulation in Calf Muscle Using MSOT
Status: RECRUITING
Conditions: Multispectral Optoacoustic Tomography|Learning Curve|Image Interpretation, Computer-Assisted|Structural Similarity Index Measure
Interventions: DEVICE: MSOT measurements
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety and Tolerability Study of an Investigational Drug, ALN-TTRSC02, in Healthy Subjects
Status: COMPLETED
Conditions: Transthyretin-mediated Amyloidosis (ATTR Amyloidosis)
Interventions: DRUG: ALN-TTRSC02|DRUG: Sterile Normal Saline (0.9% NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: BI 6727 (Volasertib) Monotherapy Phase I Trial in Japanese Patients With Advanced Solid Tumours
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Volasertib, low dose, d1q3w|DRUG: Volasertib, middle dose, d1q3w|DRUG: Volasertib, high dose, d1q3w
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Tele-Taking Charge After Stroke Randomized Controlled Feasibility Trial
Status: NOT_YET_RECRUITING
Conditions: Stroke/Brain Attack
Interventions: OTHER: Take Charge session|OTHER: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Early Treatment of PC945 on Aspergillus Fumigatus Lung Infection in Lung Transplant Patients.
Status: TERMINATED
Conditions: Aspergillosis|Lung Transplant Infection
Interventions: DRUG: PC945|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venous Injection Compared To intraOsseous Injection During Resuscitation of Patients With Out-of-hospital Cardiac Arrest
Status: COMPLETED
Conditions: Emergency Medical Service|Out-of-Hospital Cardiac Arrest|Vascular Access|Intraosseous Access|Intravenous Access
Interventions: DEVICE: intra-osseous access vs. intra-venous access
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Recurrent Clostridium Difficile Infection (CDI) in Patients With Inflammatory Bowel Disease (IBD).
Status: TERMINATED
Conditions: Inflammatory Bowel Diseases|Ulcerative Colitis|Crohn Disease|C. Diff. Infections
Interventions: BIOLOGICAL: Bezlotoxumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety Study of RPE65 Gene Therapy to Treat Leber Congenital Amaurosis
Status: COMPLETED
Conditions: Retinal Degeneration
Interventions: BIOLOGICAL: tgAAG76 (rAAV 2/2.hRPE65p.hRPE65)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Restore Motor Function Through Robotic Arm Exoskeleton and Brain Computer Interface
Status: UNKNOWN
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DEVICE: REMAP EEG based BCI and SEM-Glove BioServo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Classic Yin and Yang Tonic Formula for Osteopenia
Status: UNKNOWN
Conditions: Osteopenia
Interventions: DRUG: Yin and Yang tonic granules|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of BIA 2-093 in Combination With Other Anti-Epileptic Drugs to Treat Partial Epilepsy
Status: COMPLETED
Conditions: Partial Epilepsy
Interventions: DRUG: eslicarbazepine acetate|DRUG: placebo|DRUG: ESL - Part II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Pentoxifylline as an Adjuvant Therapy for Adult Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Escitalopram 20 mg tablet plus Pentoxifylline 400Mg Tablet|DRUG: Escitalopram 20 mg tablet + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effective Mechanisms of Wu-Chu-Yu Tang on Gastroesophageal Disorder
Status: UNKNOWN
Conditions: Wu-Chu-Yu Tang|Gastroesophageal Reflux Disorder|24 Hours Esophageal PH and Multichannel Intraluminal Impedance Testing
Interventions: DRUG: Wu-Chu-Yu tang
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Abiraterone in Combination With SHR3162 in the Treatment of mCRPC
Status: UNKNOWN
Conditions: Prostate Cancer Castration-resistant Prostate Cancer
Interventions: DRUG: Abiraterone+SHR3162
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nebulized Procaterol Versus Nebule Salbutamol for the Treatment of Moderate Acute Asthma
Status: COMPLETED
Conditions: Moderate Acute Asthma
Interventions: DRUG: Procaterol, Salbultamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT