pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: CIML NK Cell in Head & Neck Cancer
Status: RECRUITING
Conditions: Squamous Cell Carcinoma of the Head and Neck|Recurrent Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Interleukin-15 Superagonist (N-803)|BIOLOGICAL: CIML NK cell Infusion|DRUG: Ipilimumab|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Simultaneous Pressure Guided Revascularization Study
Status: COMPLETED
Conditions: Peripheral Vascular Diseases|Blood Pressure|Monitoring, Intraoperative|Clinical Decision-Making|Endovascular Procedures
Interventions: DIAGNOSTIC_TEST: Intraoperative Hemodynamic Pressures|DIAGNOSTIC_TEST: Contrast Flow Rate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Personal Electronic Health Records in Improving Screening Rates for Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: OTHER: educational intervention|OTHER: internet-based intervention|PROCEDURE: evaluation of cancer risk factors|PROCEDURE: fecal occult blood test|PROCEDURE: screening colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SCREENING
Clinical trial: Treating Early-stage Non-Small Cell Lung Cancer With Durvalumab and Radiation Therapy
Status: RECRUITING
Conditions: NSCLC|Non-small Cell Lung Cancer|Lung Cancer|Non-small Cell Lung Cancer Stage I|Non-small Cell Lung Cancer Stage II|Non-small Cell Lung Cancer Stage III|Non-small Cell Lung Cancer Stage IIIA|PD-L1 Gene Mutation
Interventions: DRUG: Durvalumab|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiac Contractility Modulation in Chagas Heart Disease
Status: UNKNOWN
Conditions: Chagas Cardiomyopathy|Heart Failure|Systolic Dysfunction|Right Bundle Branch Block and Left Anterior Fascicular Block|Right Bundle Branch Block and Left Posterior Fascicular Block
Interventions: DEVICE: Cardiac Contractility Modulation (CCM)|DEVICE: CRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: mulTi-Arm Therapeutic Study in Pre-ICu Patients Admitted With Covid-19 - Experimental Drugs and Mechanisms
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: EDP1815|DRUG: Dapagliflozin|DRUG: Ambrisentan|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Baricitinib for Moderate and Severe Traumatic Intracerebral Hemorrhage/Contusions
Status: NOT_YET_RECRUITING
Conditions: Traumatic Brain Injury
Interventions: DRUG: Baricitinib 4 MG|OTHER: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Type of Material in Repair of Congenital Diaphragmatic Hernia
Status: TERMINATED
Conditions: Congenital Diaphragmatic Hernia
Interventions: PROCEDURE: Repair of CDH w/SIS Gold|PROCEDURE: Repair of CDH w/Alloderm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Comparison of Hypotension Incidence Between Remimazolam and Propofol in Hypertensive Patients Undergoing Neurosurgery
Status: COMPLETED
Conditions: Patients Undergoing Neurosurgery
Interventions: DRUG: propofol|DRUG: remimazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Preemptive Analgesia Combination of Celecoxib and Pregabalin in THA
Status: UNKNOWN
Conditions: Arthroplasty Complications|Analgetic|Celecoxib|Pregabalin
Interventions: DRUG: Single dose of celecoxib 400 mg and pregabalin 150 mg|DRUG: Repeated dose of celecoxib 200 mg and pregabalin 75 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Neoadjuvant Taxotere, Cisplatin, and 5-Fluorouracil in Patients With Gastric or Gastroesophageal Junction Adenocarcinoma
Status: UNKNOWN
Conditions: Gastric Junction Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Taxotere, Cisplatin, and 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Toremifene Treatment to the Magnetic Resonance Imaging (MRI) Findings in Premenstrual Mastalgia
Status: COMPLETED
Conditions: Breast Pain
Interventions: DRUG: toremifene|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BL22 Immunotoxin in Treating Patients With Refractory Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia, or Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: DRUG: BL22 immunotoxin|PROCEDURE: antibody-drug conjugate therapy|PROCEDURE: immunotoxin therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeting Methods of Botulinum Toxin Injections for Cervical Dystonia
Status: COMPLETED
Conditions: Idiopathic Cervical Dystonia
Interventions: PROCEDURE: Clinical targeting|PROCEDURE: Ultrasonography targeting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impact of Perivascular Tissue on Endothelial Function in Coronary Artery Bypass Grafting
Status: UNKNOWN
Conditions: Myocardial Ischemia
Interventions: PROCEDURE: no-touch|PROCEDURE: conventional
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inspire® Upper Airway Stimulation (UAS) System German Post-Market Study
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Inspire® Upper Airway Stimulation (UAS) System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy Compared With Combination Chemotherapy in Treating Patients With Cancer of the Uterus
Status: COMPLETED
Conditions: Sarcoma
Interventions: DRUG: cisplatin|DRUG: ifosfamide|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Insoles in Prevention of Lower Limb Injuries
Status: COMPLETED
Conditions: Lower Limb Overuse Injuries
Interventions: DEVICE: custom-made insoles (Thermo+Camel, cost for the military 20,50 euros)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: PREVENTION
Clinical trial: Respiratory Effect of the LISA Method With Sedation by Propofol Versus Absence of Sedation.
Status: RECRUITING
Conditions: Respiratory Distress Syndrome in Premature Infant
Interventions: DRUG: Propofol-Lipuro|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Study Evaluating Modified Cup Anteversion Placement in Prevention of Postoperative Dislocation in Patients Undergoing Acetabular Tumor Resection and Reconstruction
Status: RECRUITING
Conditions: Periacetabular Tumor
Interventions: BEHAVIORAL: modified anteversion angle placement(( α-15°)±10°)|BEHAVIORAL: conventional anteversion angle placement ( α±10°)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of Antiplaque and Antigingivitis Efficacy of Ocimum Sanctum (Tulsi) Extract
Status: COMPLETED
Conditions: Periodontal Diseases|Gingivitis|Periodontitis
Interventions: OTHER: Ocimum sanctum|OTHER: Chlorhexidine Gluconate|OTHER: Propylene Glycol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Thulium Contact Laser of Laryngotracheal Stenosis
Status: COMPLETED
Conditions: Laryngeal Carcinoma|Bilateral Vocal Cord Paresis|Subglottic Stenosis
Interventions: PROCEDURE: laryngeal carcinoma|PROCEDURE: bilateral vocal cord paralysis|PROCEDURE: subglottic stenosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Glipizide|DRUG: Metformin|OTHER: Oral Glucose Tolerance Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Iberdomide, Daratumumab, Bortezomib, and Dexamethasone for Treatment of Newly Diagnosed Multiple Myeloma, IDEAL Study
Status: RECRUITING
Conditions: Plasma Cell Myeloma
Interventions: DRUG: Bortezomib|BIOLOGICAL: Daratumumab|DRUG: Dexamethasone|DRUG: Iberdomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploring the Efficacy and Safety of Herbal Medicine on Korean Obese Women With or Without Metabolic Syndrome Risk Factors - A Study Protocol for a Double-blind, Randomised, Multi-center, Placebo-controlled Clinical Trial
Status: COMPLETED
Conditions: Obesity|Metabolic Syndrome
Interventions: DRUG: GGT|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Investigating the Best Method of Treatment of Bile Duct Stones in Higher Risk Patients
Status: TERMINATED
Conditions: Choledocholithiasis|Higher Risk Patients
Interventions: PROCEDURE: Endoscopic sphincterotomy and subsequent laparoscopic cholecystectomy|PROCEDURE: Laparoscopic bile duct exploration during cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STAR Caregivers - Virtual Training and Follow-up
Status: COMPLETED
Conditions: Alzheimer Disease|Dementia|Caregiver Burnout
Interventions: BEHAVIORAL: STAR-C-VTF|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Hemopurifier Plus Pembrolizumab in Head and Neck Cancer
Status: TERMINATED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DEVICE: Hemopurifier|DRUG: Pembrolizumab 200mg IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prediction of Outcome After Chemoradiotherapy for Head and Neck Cancer Using Functional Imaging and Tumor Biology
Status: RECRUITING
Conditions: Head and Neck Cancer
Interventions: OTHER: functional MRI|OTHER: Hypoxia gene expression profile.|OTHER: Functional MRI before start of treatment.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Combination Therapy of Vildagliptin/Metformin in Patients in Type 2 Diabetes Mellitus (T2DM)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: vildagliptin/metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP Infections
Status: COMPLETED
Conditions: Urinary Tract Infection Symptomatic|Acute Pyelonephritis|Urinary Tract Infection Complicated
Interventions: DRUG: ZTI-01|DRUG: Piperacillin-tazobactam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The InterVitaminK Trial - Effects of Vitamin K Supplementation on Cardiovascular, Metabolic, and Bone Health
Status: RECRUITING
Conditions: Coronary Artery Calcification|Arterial Stiffness
Interventions: DIETARY_SUPPLEMENT: Menaquinone-7 (MK-7) tablet (333 µg)|DIETARY_SUPPLEMENT: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Interventions for Parent Caregivers of Injured Military/Veteran Personnel
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic|Brain Injuries, Traumatic
Interventions: OTHER: REACH Individual Session|OTHER: Education Webinar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Follow-up of Sequential Chemotherapy and Stimulation for Fertility Preservation in Young Patients With Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: PROCEDURE: Consultation|BIOLOGICAL: Biological Test|PROCEDURE: Pelvic Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: First Time in Human Study of Protexia
Status: COMPLETED
Conditions: Intervention for Nerve Agent Exposure
Interventions: BIOLOGICAL: Protexia|BIOLOGICAL: Protexia|BIOLOGICAL: Protexia|BIOLOGICAL: Protexia|BIOLOGICAL: Protexia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective, Multicenter Randomized Controlled Study of the Application of Preoperative FOLFOXIRI Chemotherapy Combined With Lateral Lymph Node Dissection in Low- and Medium-lying Rectal Cancer With Lateral Lymph Node Metastasis
Status: ENROLLING_BY_INVITATION
Conditions: Lymph Node Metastasis|Cancer of Rectum and Anus|Oxaliplatin|Intestinal Neoplasms|Gastrointestinal Neoplasms|Rectal Diseases|Rectal Neoplasms
Interventions: DRUG: Experimental: FOLFOXIRI and Lateral lymph node dissection|DRUG: Preoperative long-term concurrent chemoradiotherapy and Lateral lymph node dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantifying Bone and Skin Movement in the Residual Limb of Individuals With Transtibial Amputation Using Dynamic Stereo X-Ray
Status: RECRUITING
Conditions: Amputation, Lower Limb
Interventions: DEVICE: Suction Suspension First|DEVICE: Elevated Vacuum Suspension First
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cervical Epidural and Stellate Ganglion Block in Upper Limb Complex Regional Pain Syndrome
Status: RECRUITING
Conditions: Stellate Ganglion Block|Cervical Epidural|Complex Regional Pain Syndromes
Interventions: DRUG: Ultrasound guided Stellate ganglion block|DRUG: unilateral cervical epidural
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Avelumab Combined With Cetuximab and Irinotecan for Treatment Refractory Metastatic Colorectal Microsatellite Stable Cancer
Status: UNKNOWN
Conditions: Colorectal Neoplasms, Malignant
Interventions: DRUG: Avelumab|DRUG: Cetuximab Injection|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Controlled Trial to Test the Efficacy of Lipid-based Nutrient Supplements to Prevent Severe Stunting Among Infants
Status: COMPLETED
Conditions: Malnutrition|Stunting|Developmental Delay
Interventions: DIETARY_SUPPLEMENT: Milk-containing fortified spread|DIETARY_SUPPLEMENT: Soy-containing fortified spread|DIETARY_SUPPLEMENT: Maize-soy flour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Gefitinib Retreatment in Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Gefitinib retreatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Study of PRX167700 in Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: PRX167700|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture and Moxibustion for Hyperlipemia
Status: UNKNOWN
Conditions: Hyperlipidemias
Interventions: OTHER: acupuncture and moxibustion|DRUG: Simvastatin|OTHER: Therapeutic Lifestyle Change
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CONNECT Study - Clinical Evaluation Of Remote NotificatioN to rEduCe Time to Clinical Decision
Status: COMPLETED
Conditions: Arrhythmia|Tachycardia|Atrial Fibrillation|Ventricular Fibrillation
Interventions: OTHER: Remote Management|OTHER: In-Office Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Estimation of Biomechanical Aortic Wall Properties in Healthy and Aneurysmal Aortas Using Novel Imaging Techniques
Status: RECRUITING
Conditions: Abdominal Aortic Aneurysm
Interventions: DEVICE: ECHO|DEVICE: ECG-gated MRA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of TVB 2640 in Subjects With Non-Alcoholic Steatohepatitis (NASH)
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: TVB-2640|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Incremental Hemodialysis as a Starting Way of Renal Replacement Therapy
Status: COMPLETED
Conditions: Chronic Renal Failure
Interventions: PROCEDURE: Incremental hemodialysis|PROCEDURE: Conventional hemodialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for Hot Flashes in Hormone Receptor-Positive Breast Cancer, a Randomized Controlled Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DEVICE: Acupuncture|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Alveolar Echinococcosis: Parasite Viability and Innovative Markers for the Follow-up of Patients Treated With Albendazole
Status: COMPLETED
Conditions: Alveolar Echinococcosis
Interventions: DRUG: Benzimidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sweet Preference and Alcohol Craving
Status: COMPLETED
Conditions: Alcohol Dependence|Alcohol Abuse
Interventions: DRUG: Naltrexone|BEHAVIORAL: Brenda Therapy Sessions|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Active Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Patients Aged 12 to 17 Years With Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Vortioxetine 10 mg/day|DRUG: Vortioxetine 20 mg/day|DRUG: Fluoxetine 20 mg/day|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lung Cancer Prevention Screening Programme in Italy
Status: RECRUITING
Conditions: Lung Cancer|COPD (Chronic Obstructive Pulmonary Disease) With Acute Lower Respiratory Infection|Cardiovascular Diseases
Interventions: DIAGNOSTIC_TEST: early lung cancer detection|OTHER: blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of an Online Plant-Based Dietary Program on Cardiovascular Risk Factors in Persons With Type 2 Diabetes Mellitus: A Randomized Controlled Trial
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Diet, Vegetarian|Diet, Vegan|Cardiometabolic Risk Factors|Cholesterol, LDL|Blood Pressure|Glycemic Control|Diet Therapy
Interventions: BEHAVIORAL: 12-week plant-based dietary program|BEHAVIORAL: Usual Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock
Status: UNKNOWN
Conditions: Septic Shock|Cardiomyopathy
Interventions: DRUG: Norepinephrine|DRUG: Milrinone|DRUG: Levosimendan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Relationship of Epilepsy and Attention Deficit Hyperactive Disorder
Status: COMPLETED
Conditions: Attention-Deficit Hyperactivity Disorder|Epilepsy
Interventions: DIAGNOSTIC_TEST: electroencephalography|DIAGNOSTIC_TEST: psychometric scales to diagnosis psychiatric disorders|OTHER: psychometric scales for assesment socioeconomic and behaviour problems
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Cognitive Functions on Upper Extremity Functionality in Parkinson's Patients
Status: COMPLETED
Conditions: Parkinson|Cognitive Impairment|Upper Extremity Problem|Functional Disturbance
Interventions: DIAGNOSTIC_TEST: clinical assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Transforming Non-Invasive Liver Disease Detection by MRE: The Hepatogram
Status: COMPLETED
Conditions: Obesity|Fatty Liver
Interventions: PROCEDURE: Magnetic Resolution Elastography (MRE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Eslicarbazepine Acetate as Therapy for Patients With Painful Diabetic Neuropathy
Status: COMPLETED
Conditions: Painful Diabetic Neuropathy
Interventions: DRUG: Eslicarbazepine acetate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Transobturator Cystocele vs. Anterior Vaginal RepairS
Status: RECRUITING
Conditions: Pelvic Organ Prolapse|Cystocele|Cystocele and Incomplete Uterovaginal Prolapse
Interventions: PROCEDURE: Transobturator cystocele repair|PROCEDURE: Anterior colporrhaphy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contrast-enhanced MR Imaging as a Breast Cancer Screening in Women at Intermediate Risk
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: OTHER: Magnetic Resonance Imaging (MRI)|OTHER: Mammography (Mx) + ultrasonography (US)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Efficacy and Safety of Dianicline Treatment as an Aid to Smoking Cessation in Cigarette Smokers (AMERIDIAN)
Status: COMPLETED
Conditions: Smoking Cessation|Tobacco Use Cessation
Interventions: DRUG: SSR591813L (dianicline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Geko™ KM40C Hydrogel Skin Adhesion Trial (XW-3)
Status: NOT_YET_RECRUITING
Conditions: Leg Ulcer
Interventions: DEVICE: geko™ X-W3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Precision Medicine and Physical Function
Status: RECRUITING
Conditions: Frailty|Weakness, Muscle|Multiple Chronic Conditions
Interventions: DIETARY_SUPPLEMENT: Beta-hydroxymethyl butyrate supplement|DIETARY_SUPPLEMENT: Vitamin D supplement|DIETARY_SUPPLEMENT: Matching Beta-hydroxymethyl butyrate supplement without Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Single Dose Study of ANX005 in Healthy Volunteers
Status: TERMINATED
Conditions: Safety and Tolerability in Healthy Volunteers
Interventions: DRUG: ANX005|DRUG: IVIg|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Computer Aided Detection of Polyps During Colonoscopy Procedures
Status: COMPLETED
Conditions: Colo-rectal Cancer|Polyp of Colon|Adenomatous Polyps
Interventions: DEVICE: EndoVigilant CAD Software
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Safety and Efficacy of Generic Sofosbuvir and Ribavirin for Treatment-naive Genotype 2 Chronic Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C, Chronic|Hepatitis C Virus Infection, Response to Therapy of
Interventions: DRUG: Sofosbuvir|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Swedish Iodine in Pregnancy and Development in Children (SWIDDICH) Study
Status: RECRUITING
Conditions: Thyroid Gland; Node|Pregnancy|Cognitive Developmental Delay
Interventions: DIETARY_SUPPLEMENT: Iodine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Of Bosutinib With Capecitabine In Solid Tumors And Locally Advanced Or Metastatic Breast Cancer
Status: TERMINATED
Conditions: Advanced Breast Cancer (Parts 1 and 2)|Advanced Pancreatic Cancer (Part 1)|Advanced Colorectal Cancer (Part 1)|Advanced Cholangiocarcinoma (Part 1)|Advanced Glioblastoma Multiforme (Part 1)
Interventions: DRUG: Bosutinib|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Anaesthesia Depth on Oculo-cardiac Reflex
Status: COMPLETED
Conditions: Strabismus|Anesthesia, General
Interventions: DRUG: Desflurane|DEVICE: Bispectral index monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy And Safety Of Pregabalin For Pain Following Total Knee Replacement
Status: COMPLETED
Conditions: Osteoarthritis|Postoperative Pain
Interventions: DRUG: pregabalin|DRUG: pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Complimentary and Alternative Practices on Patient Wellbeing During Rehabilitation
Status: UNKNOWN
Conditions: Anxiety|Depression|Stress|Pain|Heart Rate|Blood Pressure
Interventions: OTHER: Conscious Breathing|OTHER: Heartfulness Meditation|OTHER: Emotional Freedom Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Virtual Peer Coaching in Manual Wheelchair Skills
Status: NOT_YET_RECRUITING
Conditions: Wheelchair|Paraplegia
Interventions: OTHER: Intervention A: 1-on-1 wheelchair skills training by a peer coach|OTHER: Intervention B: Training via educational videos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: TMC125-C203: Phase II Randomized (Patients Are Assigned Different Treatments Based on Chance), Placebo Controlled Dose Escalating Trial of TMC125 in HIV-1 Infected Patients
Status: COMPLETED
Conditions: Anti-Retroviral Agents|HIV-1
Interventions: DRUG: TMC125
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Erythropoietin to Improve Survival and Neurological Outcome in Hypoxic Ischemic Encephalopathy
Status: COMPLETED
Conditions: Hypoxic Ischemic Encephalopathy
Interventions: DRUG: erythropoietin Beta|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Reuteri in Treatment of Functional Abdominal Pain and Chronic Constipation in Children
Status: UNKNOWN
Conditions: Abdominal Pain|Constipation - Functional
Interventions: DIETARY_SUPPLEMENT: Administration of L.reuteri in children with abdominal pain|DIETARY_SUPPLEMENT: Administration of placebo in children with abdominal pain|DIETARY_SUPPLEMENT: Administration of L.reuteri in children with constipation|DIETARY_SUPPLEMENT: Administration of placebo in children with constipation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Food Effect Study of SHR1459 on Healthy Chinese Adult Subjects
Status: COMPLETED
Conditions: Healthy Adult Subjects
Interventions: DRUG: SHR1459 fasted in P1, high-fat diet in P2|DRUG: SHR1459 high-fat diet in P1, fasted in P2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Daratumumab Maintenance Therapy for Improving Survival in Patients With Light Chain Amyloidosis, EMILIA Trial
Status: RECRUITING
Conditions: AL Amyloidosis
Interventions: PROCEDURE: Bone Marrow Aspiration|BIOLOGICAL: Daratumumab|PROCEDURE: Echocardiography|OTHER: Questionnaire Administration|PROCEDURE: X-Ray Imaging|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Ascending Study to Evaluate the Safety of NH002 as a Contrast Agent in Cardiac Echocardiography
Status: COMPLETED
Conditions: Cardiac Disease
Interventions: DRUG: NH002 (Perflutren Lipid Microspheres) Injectable Suspension|DIAGNOSTIC_TEST: Echocardiogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bolus Calculator and Wireless Communication With Blood Glucose Meter in Management of Type 1 Diabetes Mellitus (T1DM).
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: CSII+BC+CL|DEVICE: CSII+BC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Maintaining Muscle Mass Gains
Status: UNKNOWN
Conditions: Using Imagery to Maintain Muscle Mass Gains in the Quadriceps
Interventions: BEHAVIORAL: Imagery|BEHAVIORAL: Muscle Maintenance|BEHAVIORAL: Bicep Curls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: A Drug Interaction Study of JNJ-31001074 and Ketoconazole in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy|Pharmacokinetics|Drug Interactions
Interventions: DRUG: JNJ-31001074; ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy of Hypnosis in Anxiety/Pain Reduction in Children During Pulpotomies
Status: UNKNOWN
Conditions: Dental Anxiety|Pain
Interventions: BEHAVIORAL: Hypnosis|BEHAVIORAL: Tell, show, do technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MiDeTe - microRNA Levels Under Denosumab and Teriparatide Therapy in Postmenopausal Osteoporosis
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis|Diabetes Type 2
Interventions: DRUG: Prolia, 60 Mg/mL Subcutaneous Solution|DRUG: Teriparatide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Concentration of Vasopressin During Robot-assisted Laparoscopic Myomectomy
Status: COMPLETED
Conditions: Uterine Leiomyoma
Interventions: DRUG: Vasopressin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Near Infrared Spectroscopy (NIRS) and Intravascular Ultrasound (IVUS) Combination Coronary Catheter
Status: COMPLETED
Conditions: Atherosclerosis|Coronary Artery Disease|Myocardial Ischemia|Myocardial Infarction
Interventions: DEVICE: Intravascular ultrasound and spectroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Human In Vivo Feeding Study Of The Blood Monocyte Response To Dietary Lipid Intake
Status: TERMINATED
Conditions: Atherosclerosis
Interventions: DIETARY_SUPPLEMENT: Mixed High Fat Diet|DIETARY_SUPPLEMENT: Saturated fat diet|DIETARY_SUPPLEMENT: Monounsaturated fat diet|DIETARY_SUPPLEMENT: Polyunsaturated fat diet|DIETARY_SUPPLEMENT: Triolein 13C|DIETARY_SUPPLEMENT: Low fat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety of and Immune Response to a Dengue Virus Vaccine (rDEN4delta30-4995) in Healthy Adults
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: rDEN4delta30-4995|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of ONTAK in Patients With B-Cell Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Leukemia, Lymphocytic, Chronic
Interventions: DRUG: ONTAK
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Combination Therapy on Knee Osteoarthritis Pain in Postmenopausal Women
Status: COMPLETED
Conditions: Non Specific Knee Osteoarthritis Pain
Interventions: DEVICE: Combination therapy (CT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Buprenorphine Transdermal System in Subjects With Moderate to Severe Osteoarthritis of Hip or Knee
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Buprenorphine transdermal patch|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Senolytics To slOw Progression of Sepsis (STOP-Sepsis) Trial
Status: RECRUITING
Conditions: Sepsis|Acute Infection|Organ Failure
Interventions: DRUG: Fisetin-dose 1|DRUG: Fisetin-dose 2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-Based College: Stage 1
Status: COMPLETED
Conditions: Diet Habit|Physical Activity|Sleep|Loneliness|Emotional Regulation|Alcohol Consumption, Youth|Stress, Psychological
Interventions: BEHAVIORAL: Mindfulness-Based College|BEHAVIORAL: Enhanced Usual Care Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Liposomal Bupivacaine for Pain Control After Rotator Cuff Repair
Status: COMPLETED
Conditions: Rotator Cuff Tear|Postoperative Pain
Interventions: DRUG: Liposomal bupivacaine (LB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacists' Intervention in Patients Using Novel Oral Anticoagulants：A Study on Behavioral Patterns
Status: RECRUITING
Conditions: Anticoagulants|Intention|Behavioral Symptoms
Interventions: OTHER: Pharmacists' intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: 177Lu-DTPA-Omburtamab Radioimmunotherapy for Leptomeningeal Metastasis From Solid Tumors (Breast, NSCLC, Malignant Melanoma)
Status: WITHDRAWN
Conditions: Leptomeningeal Metastasis|Solid Tumor, Adult
Interventions: BIOLOGICAL: radiolabeled DPTA-omburtamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ALKS 3831 in Adults With Acute Exacerbation of Schizophrenia (the ENLIGHTEN-1 Study)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: ALK3831|DRUG: Olanzapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metastases Directed Therapy for Oligometastatic Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Metastatic Cancer|Metastatic Breast Cancer
Interventions: RADIATION: Stereotactic Ablative Radiation Therapy|PROCEDURE: Locoregional treatment|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of High Flow Nasal Cannula on Sputum Clearance in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|COPD Exacerbation|Airflow Obstruction
Interventions: DEVICE: High Flow Nasal Cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Kineesiotaping for Patients With LCPD
Status: COMPLETED
Conditions: Legg-Calve-Perthes Disease
Interventions: OTHER: Kinesiotaping|OTHER: Sham taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: KRX-0502 (Ferric Citrate) in Subjects With NDD-CKD and IDA (The COMPASS Trial)
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Iron Deficiency Anemia
Interventions: DRUG: KRX-0502
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of a Sore Throat Lozenge Containing Lidocaine and Cetylpyridinium Chloride in Patients With Sore Throat Due to a Common Cold.
Status: COMPLETED
Conditions: Sore Throat Due to a Common Cold
Interventions: DRUG: Lidocaine 8mg + CPC 2mg|DRUG: Lidocaine 1mg + CPC 2mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Rituximab in Treating Patients With Previously Treated Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: fludarabine phosphate|DRUG: mitoxantrone hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ph 1b: Safety & Immunogenicity of Ad5 Based Oral Norovirus Vaccine
Status: COMPLETED
Conditions: Norovirus Infections
Interventions: BIOLOGICAL: VXA-GI.1.NN|BIOLOGICAL: Placebo Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Computerized Cognitive Remediation Therapy in Adolescents With a First Psychotic Episode
Status: UNKNOWN
Conditions: Early-onset Schizophrenia|Psychotic Disorders|Cognitive Remediation Therapy|Cognition
Interventions: BEHAVIORAL: Computerized Cognitive Remediation Therapy|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Simultaneous Renal Replacement Therapy on Extracorporeal Membrane Oxygenation Support for Cardiogenic Shock Patients
Status: UNKNOWN
Conditions: Cardiogenic Shock
Interventions: PROCEDURE: Simultaneous RRT|PROCEDURE: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of Golimumab (CNTO 148) in Subjects With Active Rheumatoid Arthritis Previously Treated With Biologic Anti-TNFa Agent(s)
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Placebo|BIOLOGICAL: Golimumab 50 mg|BIOLOGICAL: Golimumab 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remifentanil for Smooth Emergence in Elderly Patients
Status: COMPLETED
Conditions: Drug Usage
Interventions: DRUG: Remifentanil|DRUG: Remifentanil|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Absence of Intraoperative Bladder Catheterization in Case of Planned Cesarean Section
Status: RECRUITING
Conditions: Pregnant Women|Cesarean Section
Interventions: PROCEDURE: Spontaneous urination during the hour before caesarean section.|PROCEDURE: Systematic bladder catherization during caesarean section.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: ZoNantax - Zolendronic Acid as Neoadjuvant Therapy Plus Anthracycline and Taxane in Locally Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Breast Disease|Neoplasms|Neoplasms by Site
Interventions: DRUG: Zo-Nantax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Leap Motion Controller on the Functionality of Upper Limbs in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Upper Extremity Dysfunction|Therapy-Related MDS
Interventions: OTHER: Leap Motion Controller|OTHER: Conventional Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Healthy Volunteer Study to Evaluate the Ability of PRT064445 to Reverse the Effects of Several Blood Thinner Drugs on Laboratory Tests (Module 2 of 4)
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: COMBINATION_PRODUCT: PRT064445/Rivaroxaban|COMBINATION_PRODUCT: Placebo/Rivaroxaban|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Temozolomide With or Without Veliparib in Treating Patients With Relapsed or Refractory Small Cell Lung Cancer
Status: COMPLETED
Conditions: Recurrent Small Cell Lung Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Placebo|DRUG: Temozolomide|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Consolidation Serplulimab Following Concurrent Chemoradiotherapy for LS-SCLC Patients
Status: RECRUITING
Conditions: Limited Stage Small Cell Lung Cancer
Interventions: DRUG: HLX10|RADIATION: hypofractionated radiotherapy|RADIATION: Prophylactic Cranial Irradiation (PCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stability of Secondary Intraocular Lenses With no Capsular Support
Status: ENROLLING_BY_INVITATION
Conditions: Cataract
Interventions: DEVICE: IFIOL|DEVICE: SFIOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Retention of Metal Reinforced Polyamide Denture Base and Heat Cured Acrylic Resin Denture Base in Complete Mandibular Denture
Status: UNKNOWN
Conditions: Anodontia of Permanent Dentition
Interventions: OTHER: polyamide|OTHER: heat cured acrylic resin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ligament Reconstruction Weilby vs Simple Trapeziectomy
Status: COMPLETED
Conditions: Thumb Osteoarthritis
Interventions: PROCEDURE: Simple trapeziectomy|PROCEDURE: Weilby
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT