pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Tazemetostat and Mosunetuzumab in Untreated Follicular Lymphoma
Status: RECRUITING
Conditions: Follicular Lymphoma
Interventions: DRUG: Mosunetuzumab|DRUG: Tazemetostat Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hybrid Operating Treatment of Coexistence of Intracranial Aneurysms and Cerebrovascular Stenosis
Status: UNKNOWN
Conditions: Intracranial Aneurysm|Cerebrovascular Stenosis|Atheroscleroses, Cerebral
Interventions: PROCEDURE: Microsurgical aneurysmal operating techniques|PROCEDURE: endovascular techniques for cerebrovascular stenosis|PROCEDURE: endovascular techniques for intracranial aneurysms|PROCEDURE: carotid endarterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ARRY-371797 in Subjects Undergoing Third Molar Extraction
Status: COMPLETED
Conditions: Dental Pain
Interventions: DRUG: ARRY-371797, p38 inhibitor; oral|DRUG: Placebo; oral|DRUG: Placebo; oral|DRUG: ARRY-371797, p38 inhibitor; oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oriental Intervention for Enhanced Neurocognitive Health (Orient) Diet in Populations With High Risk of Stroke (ENDS)
Status: RECRUITING
Conditions: High Risk of Stroke
Interventions: BEHAVIORAL: Usual Diet advice|BEHAVIORAL: ORIENT diet intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fluorouracil, Cisplatin, and Radiation Therapy or Gemcitabine and Oxaliplatin in Treating Patients With Nonmetastatic Biliary Tract Cancer That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Extrahepatic Bile Duct Cancer|Gallbladder Cancer|Liver Cancer
Interventions: DRUG: cisplatin|DRUG: gemcitabine hydrochloride|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venetoclax and ASTX727 for the Treatment of Relapsed, Refractory, or Newly Diagnosed Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Decitabine and Cedazuridine|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Performance of Needle Placements for Neuraxial Procedures Using Tactile Imaging vs Control
Status: COMPLETED
Conditions: Central Nervous System Infections|Pseudotumor Cerebri|Neurological Disorder|Cancer|Obstetric Procedure Pain|Orthopedic Procedure Pain|Post-Dural Puncture Headache
Interventions: DEVICE: Tactile Imaging (VerTouch)|OTHER: Control (palpation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cobalt Chromium Stent With Antiproliferative for Restenosis II Trial (COSTAR II)
Status: COMPLETED
Conditions: Coronary Disease
Interventions: DEVICE: CoStar Paclitaxel Drug Eluting Coronary Stent System|DEVICE: TAXUS™ Express2™ Paclitaxel-Eluting Coronary Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Monthly Versus Biweekly Endoscopic Variceal Ligation for the Prevention of Esophageal Variceal Rebleeding
Status: COMPLETED
Conditions: Variceal Bleeding, Endoscopic Variceal Ligation
Interventions: DEVICE: Wilson-Cook four shooter saeed multi-band ligator|DEVICE: Wilson-Cook four shooter saeed multi-band ligator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acupuncture for the Treatment of Medication-Dependent Hypotension in Heart Failure
Status: UNKNOWN
Conditions: Congestive Heart Failure|Hypotension
Interventions: PROCEDURE: True Acupuncture|PROCEDURE: Sham Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pressure Ulcer Prevention: Turning for Ulcer Reduction
Status: COMPLETED
Conditions: Pressure Ulcers
Interventions: PROCEDURE: Turning or repositioning schedule|PROCEDURE: Turning or repositioning schedule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Internet Therapy for Depression Trial
Status: COMPLETED
Conditions: Chronic Pain|Major Depressive Disorder
Interventions: BEHAVIORAL: internet delivered cognitive behavioural therapy (iCBT)|BEHAVIORAL: online delivered acceptance and commitment therapy (iACT)|OTHER: Attention Control (AC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Evaluation of the Safety and Effectiveness of a Novel Gel-type Sodium Hyaluronate for the Correction of Aging Mid-face
Status: COMPLETED
Conditions: Dermal Filler|Hyaluronic Acid|Lidocaine|Aging Mid-Face
Interventions: DEVICE: 2% HA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Study That Measures the Safety and Efficacy of Deucravacitinib (BMS-986165) in Participants With Psoriasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Psoriasis
Interventions: DRUG: BMS-986165
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Preschool Children With Upper Respiratory Tract Illnesses Using Azythromycin and Lower Respiratory Tract Symptoms Using Oral Corticosteroids.
Status: COMPLETED
Conditions: Asthma|Wheezing
Interventions: DRUG: Azithromycin|DRUG: Prednisolone|OTHER: Placebo Azithromycin|DRUG: Placebo Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Rehabilitation Program in Improving Quality of Life in Patients With Esophageal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Cancer
Interventions: OTHER: exercise and dietary education|OTHER: weekly telephone consultations concerning exercise and diet.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase III Study Comparing Two Methods of Cardioplegia in Coronary Artery Bypass Surgery
Status: COMPLETED
Conditions: Coronary Artery Disease (CAD)
Interventions: DRUG: Custodiol-N|DRUG: Custodiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Transitions Clinic: A Post-Release Clinic for Recently Released Parolees With Chronic Medical Conditions
Status: COMPLETED
Conditions: Health Services Research, Prisons, Delivery of Health Care, Vulnerable Populations, Community Health Aides
Interventions: OTHER: Transitions Clinic - parolee-targeted care|OTHER: Expedited Primary Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Gemcitabine, Irinotecan and Panitumumab in Patients With Advanced and Metastatic Biliary Tract Adenocarcinoma
Status: COMPLETED
Conditions: Biliary Cancer|Cholangiocarcinoma
Interventions: DRUG: Gemcitabine, Irinotecan, Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Harvoni on Proteinuria and eGFR in Hepatitis C Virus Associated Chronic Kidney Disease (CKD)
Status: TERMINATED
Conditions: Hepatitis C|Chronic Kidney Disease
Interventions: DRUG: Sofosbuvir/Ledipasvir FDC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtue-Based vs. Cognitive-Behavioral Interventions in Patients With Chronic Medical Disease
Status: NOT_YET_RECRUITING
Conditions: Well-Being, Psychological
Interventions: BEHAVIORAL: Cognitive-Behavioral Therapy (CBT)|BEHAVIORAL: Virtue-Based Intervention (VBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Dose Finding Study of TKM-080301 Infusion in Neuroendocrine Tumors (NET) and Adrenocortical Carcinoma (ACC) Patients
Status: COMPLETED
Conditions: Cancer|Neuroendocrine Tumors|NET|Adrenocortical Carcinoma|ACC
Interventions: DRUG: TKM-080301
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Prolonged Inspiratory Time on Gas Exchange During Robot-assisted Laparoscopic Surgery With Steep Trendelenburg Position : A Crossover Randomized Clinical Trial
Status: COMPLETED
Conditions: Prostatic Neoplasm|Urinary Bladder Neoplasm
Interventions: DEVICE: Adjustment of Mechanical Ventilator Inspiratory to expiratory time ratio (1:2 to 1:1)|DEVICE: Adjustment of Mechanical Ventilator Inspiratory to expiratory time ratio (1:1 to 1:2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preference for a Prefilled Syringe or Smartject™ Device for Delivering Golimumab in Participants Suffering From Moderate-to-severe Ulcerative Colitis (MK-8259-027)
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Prefilled Syringe delivery of Golimumab|DRUG: Smartject Device delivery of Golimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Vytorin Versus Standard Treatment of Other Statins in Moderate, Moderately High and High Risk Participants (MK-0653A-406)
Status: WITHDRAWN
Conditions: Dyslipidemia
Interventions: DRUG: Ezetimibe/simvastatin|DRUG: Other Statin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Matured Dendritic Cells and Montanide® in Study Subjects With High Risk of Melanoma Recurrence
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: DC Vaccine|BIOLOGICAL: Montanide Vaccine|BIOLOGICAL: Poly-ICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET/MRI, 18F-FDG PET/CT and Whole Body MRI in Finding Extramedullary Myeloid Leukemia in Patients With Newly Diagnosed Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Acute Promyelocytic Leukemia With PML-RARA
Interventions: PROCEDURE: Computed Tomography|PROCEDURE: Diffusion Weighted Imaging|RADIATION: Fludeoxyglucose F-18|DRUG: Gadolinium|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|PROCEDURE: Three-Dimensional Spoiled Gradient MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Supra-early Post-Surgery Chemotherapy in the Treatment on GBM Patients
Status: UNKNOWN
Conditions: Glioblastoma
Interventions: DRUG: supra-early TEMODAL® chemotherapy|DRUG: standard TEMODAL® chemotherapy|RADIATION: Radiotherapy 60Gy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose Escalation Trial of Neoadjuvant Sorafenib and Concurrent Sorafenib, Cisplatin and Radiation in Locally Advanced Squamous Cell Carcinomas of the Head and Neck (SCCHN)
Status: WITHDRAWN
Conditions: Locally Advanced Squamous Cell Carcinomas of the Head and Neck (SCCHN)
Interventions: DRUG: sorafenib|DRUG: sorafenib|DRUG: sorafenib and cisplatin|DRUG: sorafenib and cisplatin|DRUG: sorafenib and cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Neoadjuvant Combination Therapy of Lenvatinib and TACE for Transplant-Eligible Large Hepatocellular Carcinoma Patients
Status: ENROLLING_BY_INVITATION
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Lenvatinib|PROCEDURE: Transcatheter Arterial Chemoembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Crovalimab in Healthy Volunteers and Participants With Paroxysmal Nocturnal Hemoglobinuria
Status: ACTIVE_NOT_RECRUITING
Conditions: Paroxysmal Hemoglobinuria, Nocturnal
Interventions: DRUG: Crovalimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Moderate Vein Graft Lesions With Paclitaxel Drug Eluting Stents: The VELETI Trial
Status: COMPLETED
Conditions: Coronary Artery Bypass Grafting
Interventions: DEVICE: Paclitaxel eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Real World Study of the Effect of Early PEG-rhGH Therapy on Cognitive Development of SGA Infants
Status: RECRUITING
Conditions: Small for Gestational Age Infant|Growth Hormone Treatment|Cognitive Developmental Disorder
Interventions: DRUG: PEG-rhGH
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effects of MBX-8025 in Patients With HoFH
Status: COMPLETED
Conditions: Homozygous Familial Hypercholesterolemia
Interventions: OTHER: Run-In Period: Placebo|DRUG: MBX-8025 50 mg (Dose Escalation Period 1)|DRUG: MBX-8025 50 mg or 100 mg (Dose Escalation Period 2)|DRUG: MBX-8025 50 mg, 100 mg or 200 mg (Dose Escalation Period 3)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TBTC Study 22: Efficacy of Once-Weekly Rifapentine and Isoniazid in Treatment of Tuberculosis
Status: COMPLETED
Conditions: Pulmonary Tuberculosis
Interventions: DRUG: Rifapentine|DRUG: Isoniazid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Motesanib With or Without Carboplatin/Paclitaxel or Panitumumab in the Treatment of Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Lung Cancer|Non-Small Cell Lung Cancer
Interventions: BIOLOGICAL: Panitumumab|DRUG: Motesanib diphosphate|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EFFICACY AND SAFETY OF OVA AND LAVAGE MEDICAL DEVICES IN THE TREATMENT OF NON-SPECIFIC VULVOVAGINITIS
Status: COMPLETED
Conditions: Vaginosis, Bacterial
Interventions: DEVICE: Logusgyn ovules|DEVICE: Logusgyn Lavander|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fed Study of Azithromycin Tablets 600 mg to Zithromax® Tablets 600 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Azithromycin Tablets 600 mg|DRUG: Zithromax® Tablets 600 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Retinoblastoma
Interventions: DRUG: vincristine|DRUG: topotecan|DRUG: filgrastim|DRUG: PEG-filgrastim|DRUG: carboplatin|OTHER: focal therapy|DRUG: etoposide|DRUG: cyclophosphamide|DRUG: MESNA|DRUG: doxorubicin|PROCEDURE: enucleation|RADIATION: external beam radiation or proton beam radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Glycine for Obsessive Compulsive Disorder
Status: COMPLETED
Conditions: Obsessive Compulsive Disorder
Interventions: DRUG: glycine|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modulating Energy Density in Time-Restricted Eating
Status: RECRUITING
Conditions: Insulin Resistance|Body Weight
Interventions: BEHAVIORAL: Low-energy dense diet|BEHAVIORAL: Usual diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Orchiopexy Repair
Status: COMPLETED
Conditions: Testicle Undescended|Pain, Postoperative
Interventions: PROCEDURE: Ilioinguinal/iliohypogastric nerve block|PROCEDURE: Caudal-epidural nerve block|DRUG: Acetaminophen|DRUG: Sevoflurane|DRUG: Remifentanil|DRUG: Propofol|DRUG: Morphine|DRUG: Ondansetron|DRUG: Dexamethasone|DRUG: Ketorolac|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Subcutaneous Secukinumab in Adults With Moderate to Severe Scalp Psoriasis
Status: COMPLETED
Conditions: Chronic Scalp Psoriasis
Interventions: BIOLOGICAL: Secukinumab 300 mg|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mix and Match of the COVID-19 Vaccine for Safety and Immunogenicity
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: mRNA-1273 SARS-CoV-2 vaccine|BIOLOGICAL: BNT162b2|BIOLOGICAL: ChAdOx1-S [recombinant]|OTHER: 0, 28 day schedule|OTHER: 0, 112 day schedule|BIOLOGICAL: Covifenz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Alcohol Screening and Preoperative Intervention Research Study - 2
Status: RECRUITING
Conditions: Alcohol Drinking
Interventions: BEHAVIORAL: Enhanced Usual Care (pre-operative)|BEHAVIORAL: Preoperative Virtual Health Coaching|BEHAVIORAL: Usual surgical care (post-operative)|BEHAVIORAL: Postoperative Virtual Health Coaching|BEHAVIORAL: On-Track (Post-operative)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Removal of Protein Bound Uremic Toxins by Modified Plasma Separation and Adsorption Combined With Hemodialysis
Status: UNKNOWN
Conditions: Uremia
Interventions: PROCEDURE: mFPSA treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Proprioceptive Neuromuscular Facilitation Techniques in Proximal Humerus Fractures
Status: NOT_YET_RECRUITING
Conditions: Proximal Humeral Fracture
Interventions: OTHER: Proprioceptive Neuromuscular Facilitation|OTHER: Control Group Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Monocentric Pilot Study Investigating the Metabolic Activity of Melanoma in Vivo During Sorafenib and Dacarbazine
Status: COMPLETED
Conditions: Melanoma Stage III or IV|No Prior Chemotherapy
Interventions: DRUG: Sorafenib (Nexavar), Dacarbazine (DTIC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of JT001 (VV116) Compared With Favipiravir
Status: TERMINATED
Conditions: Moderate to Severe COVID-19
Interventions: DRUG: JT001|DRUG: JT001 placebo|DRUG: Favipiravir|DRUG: Favipiravir placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Morbidly Obese Adolescent With a Duodena-jejunal Liner
Status: COMPLETED
Conditions: Obesity|Diabetes|Metabolic Syndrome
Interventions: DEVICE: Duodena-jejunal liner
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Group Treatment for Depression: A Study of Metacognitive Therapy, Mindfulness and Support Groups
Status: UNKNOWN
Conditions: Depression
Interventions: BEHAVIORAL: Metacognitive therapy|BEHAVIORAL: Mindfulness based cognitive therapy, group|BEHAVIORAL: Support groups
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MB-CART20.1 Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma|B-cell Lymphoma Refractory|B-cell Lymphoma Recurrent
Interventions: BIOLOGICAL: MB-CART20.1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polycystic Ovary Syndrome, Mitochondrial Dysfunction, Obesity, Insulin Resistance Infertility (POMODORI) Cohort
Status: RECRUITING
Conditions: Infertility, Female|Polycystic Ovary Syndrome|Insulin Resistance|Primary Ovarian Insufficiency|Mitochondrial Alteration|Obesity
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Autologous Memory-like NK Cell Therapy With BHV-1100 (Formerly KP1237), Low Dose IL-2 in Multiple Myeloma Patients
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: COMBINATION_PRODUCT: CIML NK Cells plus KP1237 and low dose IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robotic Assisted Transanal Total Mesorectal Excision Surgery for Rectal Cancer in Low Site
Status: UNKNOWN
Conditions: Rectal Neoplasms
Interventions: PROCEDURE: R-TME|PROCEDURE: R-TaTME
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Body Position on Hemodynamics in Patients With Acute Ischemic Stroke Undergoing Ultra-early Reperfusion Therapy
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DEVICE: Transcranial Doppler.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Auditory Processes and Emotional Perception in Schizophrenia
Status: UNKNOWN
Conditions: Basic Auditory Processes|Emotional Perception|Source Monitoring Deficits
Interventions: BEHAVIORAL: cognitive experiments' session
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reduction of Corticosteroid Use in Outpatient Treatment of Exacerbated COPD
Status: RECRUITING
Conditions: Pulmonary Disease, Chronic Obstructive|Adverse Effect of Glucocorticoids and Synthetic Analogues|Disease Exacerbation
Interventions: DRUG: Placebo|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anterior Defect Correction With Mesh Plus Treatment of Stress Incontinence With Transobturator or Transvaginal Approach
Status: TERMINATED
Conditions: Cystocele|Stress Urinary Incontinence
Interventions: PROCEDURE: Transobturatory correction of anterior defect plus TOT|PROCEDURE: Transobturatory correction of anterior defect plus TVT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Venous Air Plethysmography Assessment of Venous Hemodynamics in Patients Suspected Deep Venous Obstruction Used in Conjunction With Intermittent Pneumatic Compression.
Status: NOT_YET_RECRUITING
Conditions: Deep Vein Thrombosis
Interventions: DEVICE: Mayo Dopplex ABIlity|DEVICE: Intermittent Pneumatic Compression (IPC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours
Status: RECRUITING
Conditions: Pancreatic Cancer|Colorectal Cancer|Non-small Cell Lung Cancer|Head and Neck Cancer|Cancer of Unknown Primary Site|Ovarian Cancer|Breast Cancer|Soft Tissue Sarcoma|Bladder Cancer|Oesophageal Cancer|Prostate Cancer|Biliary Tract Cancer
Interventions: DRUG: AVA6000
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Akt Inhibitor MK2206 in the Treatment of Recurrent Platinum-Resistant Ovarian, Fallopian Tube, or Peritoneal Cancer
Status: COMPLETED
Conditions: Ovarian Sarcoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma
Interventions: DRUG: Akt Inhibitor MK2206|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of an Intrastromal Transform™ Corneal Allograft (TCA) for Presbyopia Correction
Status: TERMINATED
Conditions: Presbyopia
Interventions: OTHER: TCA Intrastromal Inlay
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrated Traditional Chinese and Western Medicine to Care for the Late Stage of Mild to Moderate Burns and Scalds
Status: RECRUITING
Conditions: Burns and Scalds
Interventions: OTHER: Chinese medicine for internal or external use、Acupuncture or Laser acupuncture pen treatment、Acupoint Tuina massage、Acupoint application of traditional Chinese herbal medicinal cake|OTHER: Western medicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CBM588 in Improving Clinical Outcomes in Patients Who Have Undergone Donor Hematopoietic Stem Cell Transplant
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm
Interventions: OTHER: Best Practice|DRUG: Clostridium butyricum CBM 588 Probiotic Strain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study in Healthy Male Volunteers to Investigate the Safety and Tolerability of a Single Dose of Neosaxitoxin Alone and in Combination With Bupivacaine (With and Without Epinephrine) for Brachial Plexus Blockade
Status: TERMINATED
Conditions: Anesthesia|Anesthesia, Local|Analgesia
Interventions: COMBINATION_PRODUCT: Neosaxitoxin combined with bupivacaine low and epinephrine (T1)|COMBINATION_PRODUCT: Bupivacaine low combined with epinephrine (C1)|COMBINATION_PRODUCT: Bupivacaine high combined with epinephrine (C2)|COMBINATION_PRODUCT: Neosaxitoxin combined with bupivacaine low (T2)|DRUG: Bupivacaine low (C3)|DRUG: Bupivacaine high (C4)|DRUG: Neosaxitoxin (T3)|COMBINATION_PRODUCT: Neosaxitoxin combined with epinephrine (T4)|COMBINATION_PRODUCT: Neosaxitoxin combined with bupivacaine low and epinephrine|COMBINATION_PRODUCT: Neosaxitoxin combined with bupivacaine low
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety of RUTI® Vaccination in MDR-TB Patients
Status: TERMINATED
Conditions: Tuberculosis, Multidrug Resistant
Interventions: BIOLOGICAL: RUTI® Therapeutic vaccine|BIOLOGICAL: Matching RUTI® Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Efficacy Study of Titratable Versus Active Mandibular Advancement Splint in Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Somnyx ®|DEVICE: Narval ORM ® or SomnoDent ®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Study of EZYPRO® in Atrial Fibrillation Detection on ESUS Patients
Status: UNKNOWN
Conditions: Atrial Fibrillation|Embolic Stroke of Undetermined Source
Interventions: DEVICE: EZYPRO® ECG Recorder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: HOME Study: a Combination Support Package to Increase Uptake of PrEP and HIV/STI Testing
Status: COMPLETED
Conditions: HIV Prevention|Sexually Transmitted Diseases|Pre-Exposure Prophylaxis
Interventions: BEHAVIORAL: HOME Study intervention|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Validation of Ultrasound "Angle of Progression" Measurement to Decrease the Cesarean Rate
Status: RECRUITING
Conditions: Prolonged Second Stage of Labor
Interventions: DIAGNOSTIC_TEST: Transperineal ultrasound measurements of AOP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cost Effectiveness of Glargine Insulin Versus NPH Insulin
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: insulin glargine|DRUG: Insulin NPH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase II Trial of ART + Dual bNAbs vs. ART + Placebo During Primary HIV-1 Infection-impact on Post-ART Control
Status: RECRUITING
Conditions: HIV/AIDS and Infections
Interventions: DRUG: Recombinant human monoclonal antibody (bNAbs)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treating Locally Advanced Head and Neck Malignant Tumor With Anlotinib and Chemoradiotherapy
Status: UNKNOWN
Conditions: Head and Neck Cancer
Interventions: DRUG: Anlotinib hydrochloride capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deprescribing: a Portrait and Out-comes of the Reduction of Polypharmacy in Portugal
Status: UNKNOWN
Conditions: Polypharmacy|Deprescriptions
Interventions: BEHAVIORAL: Elderly Enablement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of an Oligomeric Diet in Intestinal Absorption and Inflammatory Markers in Patients With Crohn Disease
Status: UNKNOWN
Conditions: Crohn Disease|Absorption; Disorder, Protein|Absorption; Disorder|Absorption; Disorder, Fat|Absorption; Disorder, Carbohydrate|Malnutrition
Interventions: DIETARY_SUPPLEMENT: Peptidic+Probiotic|DIETARY_SUPPLEMENT: Peptidic+Placebo|DIETARY_SUPPLEMENT: Polymeric+Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The OBstetric Lidocaine Patch (OBLido) Trial
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Transdermal Lidocaine Patch|DRUG: Transdermal Hydrocolloid Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of IV Gamma Globulin As a Method to Improve Kidney Transplant Survival in Patients With End-Stage Renal Disease Who Are Highly Sensitized to Transplant Antigens
Status: COMPLETED
Conditions: End-Stage Renal Disease|Kidney Transplantation
Interventions: BIOLOGICAL: Intravenous immune globulin (IVIG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Postoperative Pain With Preemptive Analgesia in Cesarean Section
Status: UNKNOWN
Conditions: Labor Pain
Interventions: DRUG: Bupivacaine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fulvestrant 500mg With Exemestane Endocrine Therapy for Postmenopausal Advanced Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Fulvestrant 500 mg|DRUG: Exemestane 25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Macrophage Phenotype in Type 2 Diabetics After Myocardial Infarction and the Potential Role of miRNAs Secreted
Status: COMPLETED
Conditions: DIABETES|MYOCARD INFARCTUS
Interventions: PROCEDURE: blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain Irradiation
Status: ACTIVE_NOT_RECRUITING
Conditions: Brain Tumor|Low Grade Glioma|Astrocytoma|Ependymoma|Ganglioglioma
Interventions: RADIATION: Proton radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of NIVOLUMAB/IPILIMUMAB Maintenance in Unresectable Locally Advanced or Metastatic Urothelial Cancer
Status: RECRUITING
Conditions: Urothelial Cancer
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Topical and Systemic Tranexemic Acid on Bleeding During Ear Exploration Surgery
Status: UNKNOWN
Conditions: Intraoperative Bleeding
Interventions: DRUG: Tranexamic Acid|DRUG: Tranexamic Acid|DRUG: Adrenalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Atrial Cardiomyopathy Using MRI as a Predictor of Cardiac Post-Operative Atrial Fibrillation After Cardiac Surgery.
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Bypass Grafting
Interventions: DEVICE: cardiac Magnetic Resonance Imaging (MRI)|BIOLOGICAL: Blood sample|PROCEDURE: Cardiac muscle biopsy|DEVICE: Holter-electrocardiogram (ECG)|OTHER: medical examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Stabilization Exercises and Pelvic Floor Muscle Training in Women With Stress Urinary Incontinence
Status: UNKNOWN
Conditions: Stress Urinary Incontinence
Interventions: OTHER: Pelvic floor exercises|OTHER: Stabilization exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Normative Values for Cognitive Testing and Alzheimer's Imaging Biomarkers in Young Adults
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: F-18 FDG|DRUG: C-11 PiB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Preemptive Acetaminophen for Postoperative Pain Control Following Minimally Invasive Hysterectomy
Status: WITHDRAWN
Conditions: Post Operative Pain
Interventions: DRUG: Acetaminophen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Foot and Abdominal Massage Applied to After Colonoscopy
Status: COMPLETED
Conditions: Abdominal Pain|Distention|Satisfaction, Patient
Interventions: OTHER: foot massage|OTHER: abdominal massage|OTHER: foot and abdominal massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Human Challenge Study to Evaluate the Efficacy of MV-012-968 Vaccine
Status: COMPLETED
Conditions: RSV Infection
Interventions: BIOLOGICAL: MV-012-968|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial of Intravitreal Injection of Autologous Bone Marrow Stem Cells in Patients With Retinitis Pigmentosa
Status: COMPLETED
Conditions: Retinitis Pigmentosa
Interventions: BIOLOGICAL: Intravitreal injection of Autologous bone marrow Stem Cell|OTHER: Subconjunctival injection of saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Goal Directed Numeric Coaching as a Means of Preoxygenation
Status: COMPLETED
Conditions: Pre-oxygenation
Interventions: BEHAVIORAL: Group A Standard 4 deep breaths measured in milliliters from the ventilator.|BEHAVIORAL: Group B Coached 4 deep breaths measured in milliliters from the ventilator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pediatric-Inspired Chemotherapy Plus Tyrosine Kinase Inhibitor in Adult Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
Status: WITHDRAWN
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Dasatinib|DRUG: Ponatinib|DRUG: Berlin-Frankfurt-Münster Chemotherapy|DRUG: Methotrexate and Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of Burfiralimab(hzVSF-v13) and OAD (Oral Antiviral Drug)
Status: RECRUITING
Conditions: Chronic Hepatitis B
Interventions: DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Staphylococcus Aureus Toxoids Phase 1-2 Vaccine Trial
Status: COMPLETED
Conditions: Staphylococcus Aureus
Interventions: BIOLOGICAL: Monovalent rAT|BIOLOGICAL: Monovalent rLukS-PV|BIOLOGICAL: Bivalent rLukS-PV / rAT|BIOLOGICAL: Placebo with adjuvant|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy, Safety and Response Predictors of Adjuvant Astragalus Therapy for Diabetic Kidney Disease
Status: UNKNOWN
Conditions: Diabetic Nephropathies|Diabetic Kidney Disease
Interventions: DRUG: Astragalus Powder|OTHER: Routine medical care (active comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Mometasone Furoate/Formoterol Combination Versus Formoterol and Mometasone Furoate Alone in COPD (Study P04229AM4)(COMPLETED)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Mometasone furoate/formoterol (MF/F) combination|DRUG: Mometasone furoate/formoterol (MF/F) combination|DRUG: Mometasone furoate MDI (MF MDI)|DRUG: Formoterol MDI|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Imaging-Portfolio Diet Study #7
Status: WITHDRAWN
Conditions: Cardiovascular Diseases|Hypercholesterolemia|Diabetes|Metabolic Syndrome|Obesity
Interventions: BEHAVIORAL: Portfolio Plus Diet|BEHAVIORAL: DASH-like (high fibre) dietary advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Antidepressants on the Treatment for Korean Major Depressive Disorder Patients
Status: TERMINATED
Conditions: Major Depressive Disorder
Interventions: DRUG: paroxetine|DRUG: Escitalopram|DRUG: Venlafaxine XR|DRUG: Paroxetine+Bupropion|DRUG: Paroxetine+Lamotrigine|DRUG: Paroxetine+Lithium|DRUG: Escitalopram+Mirtazapine|DRUG: Escitalopram+Aripiprazole|DRUG: Paroxetine + Venlafaxine XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GEM05 for Patients With Multiple Myeloma More Than 65 Years Old
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Melphalan/Prednisone/Velcade|DRUG: Thalidomide/Prednisone/Velcade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Different Electrical Stimulation Placement in Patients With Overactive Bladder Syndrome
Status: UNKNOWN
Conditions: Overactive Bladder Syndrome
Interventions: DEVICE: Parasacral transcutaneous electrical stimulation|DEVICE: Intravaginal electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase 1, Open-label, Drug-drug Interaction Study With Octreotide Acetate Injection and Telotristat Etiprate in Healthy Subjects
Status: COMPLETED
Conditions: Drug Interactions
Interventions: DRUG: Telotristat etiprate|DRUG: Octreotide acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Automated Postoperative Sedation After Cardiac Surgery
Status: TERMINATED
Conditions: Anesthesia|Sedation|Surgery, Cardiac
Interventions: DEVICE: EasyTiva (algorithm is the property of Medsteer SAS)|DRUG: Propofol|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: "Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients"
Status: COMPLETED
Conditions: Breast Cancer Female|Peripheral Neuropathy
Interventions: DRUG: Pentoxifylline|DRUG: Paclitaxel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Phase II Double Blind Comparative Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)
Status: COMPLETED
Conditions: SCD
Interventions: DRUG: KPS-0373|DRUG: KPS-0373|DRUG: KPS-0373|DRUG: KPS-0373|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of NX-1207 for the Treatment of Benign Prostatic Hyperplasia (BPH) (Enlarged Prostate)
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia (BPH)|Enlarged Prostate
Interventions: DRUG: 2.5 mg NX-1207|DRUG: 0.125 mg NX-1207|DRUG: finasteride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Melatonin on Coronary Artery Calcification
Status: UNKNOWN
Conditions: Coronary Artery Calcification
Interventions: DRUG: Melatonin 3 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: LUNG-05: Investigating Chemotherapy Effectiveness for Non-Small Cell Lung Cancer (NSCLC) Metastatic Patients
Status: NOT_YET_RECRUITING
Conditions: NSCLC
Interventions: DRUG: Docetaxel|DRUG: Paclitaxel|DRUG: Gemcitabine|DRUG: Pemetrexed|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy for Recurrent Cervical Cancer Refractory to Platinum-based Chemotherapy: Multi-Center Trial
Status: UNKNOWN
Conditions: Recurrent Cervical Carcinoma|Persistent Advanced Cervical Carcinoma|Chemotherapy|Immune Checkpoint Inhibitors|Anti-PD-1 Antibody|Albumin-bound Paclitaxel
Interventions: DRUG: Anti-PD-1 antibody camrelizumab|DRUG: Albumin-bound paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tislelizumab Combined With Fruquintinib for Metastatic pMMR/MSS Colorectal Cancer
Status: WITHDRAWN
Conditions: Metastatic Colorectal Cancer|mCRC
Interventions: DRUG: Tislelizumab & Fruquintinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2b Study to Investigate the Safety and Efficacy of TIN816 in Sepsis-associated Acute Kidney Injury (SA-AKI)
Status: RECRUITING
Conditions: Acute Kidney Injury Due to Sepsis
Interventions: BIOLOGICAL: TIN816 70 mg lyophilisate powder|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Tributyrin Supplementation in Acute Pancreatitis
Status: RECRUITING
Conditions: Acute Pancreatitis
Interventions: DIETARY_SUPPLEMENT: Micro-encapsulated granules of tributyrin (intervention)|DIETARY_SUPPLEMENT: Micro-encapsulated granules of sunflower oil (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT