pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase II Trial of Efprezimod Alfa (CD24Fc, MK-7110) for the Prevention of Acute Graft-Versus-Host Disease (GVHD) Following Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) (MK-7110-002)
Status: COMPLETED
Conditions: Graft Versus Host Disease|Hematopoietic Stem Cell Transplantation|Leukemia
Interventions: DRUG: Efprezimod alfa|DRUG: Methotrexate|DRUG: Tacrolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single-dose, Comparative Bioavailability Study of Two Formulations of Sarpogrelate HCl 300mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Anpl-one SR Tab. 300mg|DRUG: Sarpodipil SR Tab. 300mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Photobiomodulation Conditioning in Impacted Third Molars
Status: COMPLETED
Conditions: Impacted Third Molar Tooth
Interventions: DEVICE: Infrared LED|DEVICE: Similar device - Infrared ED
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Video Decision Support Tool to Assist Elderly Patients in ESRD Treatment Decision-making
Status: COMPLETED
Conditions: Chronic Kidney Disease|Decision-making
Interventions: OTHER: End-stage renal disease treatment options
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Monoclonal Antibody Therapy Against Chronic Herpes Simplex Virus 2 Infection
Status: COMPLETED
Conditions: Herpes Genitalis
Interventions: BIOLOGICAL: HDIT101|DRUG: Valaciclovir|BIOLOGICAL: HDIT101 placebo|DRUG: Valaciclovir placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Epinephrine and Clonidine as Adjuvants to Lidocaine in Axillary Brachial Plexus Block.
Status: COMPLETED
Conditions: Brachial Plexus Blockade
Interventions: PROCEDURE: axillary brachial plexus block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: MSB11022 in Moderate to Severe Rheumatoid Arthritis
Status: COMPLETED
Conditions: Moderate to Severe Rheumatoid Arthritis
Interventions: DRUG: MSB11022|DRUG: EU-Humira
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: S8809-S9800-S9911TM- Biological Markers in Patients With Follicular Lymphoma Treated on Clinical Trial SWOG-8809, SWOG-9800, or SWOG-9911
Status: COMPLETED
Conditions: Lymphoma
Interventions: GENETIC: microarray analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: AGEN1884, an Anti-CTLA-4 Human Monoclonal Antibody in Subjects With Advanced or Refractory Cancer and Who Have Progressed With PD-1/PD-L1 Inhibitor as Their Most Recent Therapy
Status: COMPLETED
Conditions: Advanced Solid Cancers|Advanced Solid Cancers Refractory to PD-1
Interventions: DRUG: AGEN1884
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Co-administration of Metformin and Daclatasvir on the Pharmacokinetis and Pharmacodynamics of Metformin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Hepatitis C|Drug Interactions
Interventions: DRUG: Metformin|DRUG: Daclatasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Detecting Anal and Genital Human Papillomavirus Infection and Squamous Intraepithelial Lesions in HIV-Positive Patients Enrolled in AIDS Cancer Clinical Trials
Status: COMPLETED
Conditions: Aids-related Malignancies|Lymphoma|Precancerous Condition|Sarcoma
Interventions: GENETIC: polymerase chain reaction|OTHER: cytology specimen collection procedure|OTHER: histological technique|PROCEDURE: colposcopic biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SLeep and IMagery Correlates (SOMMEIL-IMAGERIE)
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Imagery and Sleep questionnaires|OTHER: MEG recordings (pre-test)|OTHER: Practice session|OTHER: MEG recordings (Post-test)|OTHER: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hyperoxia and Hypertonic Saline in Septic Shock
Status: TERMINATED
Conditions: Septic Shock|Adult Respiratory Distress Syndrome
Interventions: DRUG: oxygen and saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Administration of L-carnitine in Hemodialysis Patients
Status: COMPLETED
Conditions: Complication of Hemodialysis|Hyperthyroidism Treated or Under Control
Interventions: DRUG: L-Carnitine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of EPA and DHA in the Inflammation and Metabolic Disorders in DMD/DMB Patients
Status: COMPLETED
Conditions: Muscular Dystrophy, Duchenne
Interventions: DIETARY_SUPPLEMENT: EPA and DHA|DIETARY_SUPPLEMENT: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo
Status: COMPLETED
Conditions: Erysipelas|Impetigo|Herpes Zoster|Molluscum Contagiosum|Warts|Tinea|Melanoma|Actinic Keratosis|Basal Cell Carcinoma|Squamous Cell Carcinoma
Interventions: PROCEDURE: Screening|DEVICE: Tele-dermatology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Retatrutide|DRUG: Semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Early Versus Delay Reconstruction in Anterior Cruciate Ligament Tearing
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Tear
Interventions: PROCEDURE: early reconstruction|PROCEDURE: delay reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetes Interventional Assessment of Slimming or Training to Lessen Inconspicuous Cardiovascular Dysfunction
Status: RECRUITING
Conditions: Diabetes
Interventions: DIETARY_SUPPLEMENT: Cambridge Weight Plan|OTHER: Supervised Exercise Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Pharmacokinetic Profile of Prazosin and Cyproheptadine
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder
Interventions: DRUG: Prazosin + cyproheptadine|DRUG: KT110
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Access the Safety and Efficacy of CT0590 in Patients With Relapsed and/or Refractory Multiple Myeloma
Status: UNKNOWN
Conditions: Relapsed and/or Refractory Multiple Myeloma
Interventions: BIOLOGICAL: CT0590 CAR T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Study The Incidence And Outcome Of Paracentesis Induced Circulatory Dysfunction in Decompensated Cirrhotics Undergoing Less Than 5 Litres Of Ascitic Fluid Tap With Or Without Albumin Infusion.
Status: COMPLETED
Conditions: Decompensated Cirrhosis
Interventions: DRUG: Albumin|DRUG: ascitic fluid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mucociliary Clearance Techniques in Moderate Bronchiolitis
Status: COMPLETED
Conditions: Bronchiolitis
Interventions: OTHER: Assisted autogenous drainage group (DAA)|OTHER: Group prolonged slow expiration (ELPr)|OTHER: Control group (CG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Combination Chemotherapy Before Surgery in Treating Patients With Locally Advanced Esophageal or Stomach Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Esophagus|Adenocarcinoma of the Gastroesophageal Junction|Diffuse Adenocarcinoma of the Stomach|Intestinal Adenocarcinoma of the Stomach|Mixed Adenocarcinoma of the Stomach|Squamous Cell Carcinoma of the Esophagus|Stage IA Esophageal Cancer|Stage IA Gastric Cancer|Stage IB Esophageal Cancer|Stage IB Gastric Cancer|Stage IIA Esophageal Cancer|Stage IIA Gastric Cancer|Stage IIB Esophageal Cancer|Stage IIB Gastric Cancer|Stage IIIA Esophageal Cancer|Stage IIIA Gastric Cancer|Stage IIIB Esophageal Cancer|Stage IIIB Gastric Cancer|Stage IIIC Esophageal Cancer|Stage IIIC Gastric Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: oxaliplatin|DRUG: leucovorin calcium|DRUG: fluorouracil|PROCEDURE: therapeutic conventional surgery|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sense of Coherence and Empowerment at Patients With MUPS
Status: RECRUITING
Conditions: Medically Unexplained Symptoms|Sense of Coherence
Interventions: BEHAVIORAL: Metacognitive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy of Solithromycin in Adolescents and Children With Community-Acquired Bacterial Pneumonia
Status: TERMINATED
Conditions: Community-acquired Bacterial Pneumonia
Interventions: DRUG: Solithromycin|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retrieval of Sperm From Men With Azoospermia Using Ultrasound-guided Rete Testis Aspiration
Status: ACTIVE_NOT_RECRUITING
Conditions: Azoospermia, Nonobstructive|Infertility, Male
Interventions: PROCEDURE: Ultrasound-guided rete testis flushing and aspiration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Functional Training by High Intensity Intervals in Older Adults With Mild Cognitive Impairment.
Status: COMPLETED
Conditions: Quality of Life|Aging
Interventions: OTHER: HIFT Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of JANX008 in Subjects with Advanced or Metastatic Solid Tumor Malignancies
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer|Renal Cell Carcinoma|Squamous Cell Carcinoma of the Head and Neck|Colorectal Carcinoma|Small Cell Lung Cancer|Pancreatic Ductal Adenocarcinoma|Triple-negative Breast Cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determining the Effect of Breathing Exercise Applied to Children Aged 6-12 Before Enema on Anxiety, Fear and Pain
Status: COMPLETED
Conditions: Constipation|Distention|Child, Only
Interventions: BEHAVIORAL: Breathing exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Simultaneous Integrated Boost Radiotherapy and Concurrent Chemotherapy for Locally Advanced Esophageal Carcinoma
Status: COMPLETED
Conditions: Esophageal Neoplasms
Interventions: RADIATION: IMRT simultaneous integrated boost|DRUG: Paclitaxel|DRUG: Nedaplatin|PROCEDURE: Esophagectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Chemical Renal Ethanol Sympatholysis Under CT Guidance Use for the Control of Therapy-Resistant Hypertension
Status: TERMINATED
Conditions: Hypertension Resistant to Conventional Therapy|Kidney Failure, Chronic
Interventions: PROCEDURE: Renal sympathicolysis|PROCEDURE: Ambulatory Blood Pressure Monitoring|RADIATION: Magnetic Resonance Angiography|BIOLOGICAL: Blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of HC-58 in Upper Limb Hemiplegic Patients After Stroke
Status: COMPLETED
Conditions: Severe Upper Limb Hemiplegia
Interventions: DRUG: HC-58|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Whole Body Vibration Training on Body Composition
Status: WITHDRAWN
Conditions: Body Composition, Beneficial|Physical Fitness
Interventions: DEVICE: HyperVibe Whole Body Vibration training device|OTHER: Aerobic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Multidimensional Physiotherapy in Chronic Nonspecific Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain, Mechanical
Interventions: OTHER: Multidimensional physiotherapy|OTHER: Usual physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Umbilical Cord Blood Transplantation in Adult Patient With Advanced Hematopoietic Malignancies
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|Myelodysplasia|Acute Lymphoblastic Leukemia|Chronic Myelogenous Leukemia|Multiple Myeloma|Lymphoma, Large-Cell, Diffuse|Lymphoma, Mantle-Cell|Lymphoma, T-Cell, Peripheral|T-NK Cell Lymphoma|Hodgkin Disease
Interventions: OTHER: umbilical cord stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of EndoFlip as a Clinical Tool for the Prediction of Postoperative GERD After Sleeve Gastrectomy
Status: NOT_YET_RECRUITING
Conditions: Gastroesophageal Reflux|Sleeve Gastrectomy|Bariatric Surgery Complication
Interventions: PROCEDURE: sleeve gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: tDCS Intervention in Primary Progressive Aphasia
Status: COMPLETED
Conditions: Primary Progressive Aphasia|MCI|FTD
Interventions: DEVICE: Active HD-tDCS plus Speech-Language Therapy|DEVICE: Sham plus Speech-Language Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Community Singing Interventions for Postnatal Depression: a Hybrid Type II Effectiveness-implementation Trial
Status: RECRUITING
Conditions: Postnatal Depression
Interventions: BEHAVIORAL: Melodies for Mums|BEHAVIORAL: Control Community Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Innovation in Pulmonary Rehabilitation
Status: COMPLETED
Conditions: Pulmonary Disease|Pulmonary Emphysema
Interventions: BEHAVIORAL: Breathing retraining|BEHAVIORAL: Heliox|BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Promethazine for Treatment of Diabetic Gastroparesis
Status: TERMINATED
Conditions: Diabetic Gastroparesis
Interventions: DRUG: Promethazine|DRUG: Sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prednisone in Cystic Fibrosis Pulmonary Exacerbations
Status: COMPLETED
Conditions: Cystic Fibrosis Pulmonary Exacerbation
Interventions: DRUG: Prednisone|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: E-NOSE for Breath Gas Analysis Under Microgravity Conditions
Status: UNKNOWN
Conditions: Healthy Volunteers
Interventions: OTHER: measurement of the concentration of C02, CO and NH4, 3 exhaled gas with E-Nose system|OTHER: Parabolic flight
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of the T12-L1 Vertebral Manipulation on Body Temperature, Arterial Tension and Cardiac Frequency
Status: COMPLETED
Conditions: Healthy Subjects|Spinal Manipulation|Manual Therapy
Interventions: OTHER: Bilateral vertebral manipulation of the T12-L1 vertebra through manual therapy|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Secukinumab in Participants With Moderate-severe Rotator Cuff Tendinopathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Rotator Cuff Tendinopathy
Interventions: DRUG: Secukinumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Opioids for Pain Control After Cesarean Delivery: Determining the Optimal Dose
Status: COMPLETED
Conditions: Analgesia, Obstetrical|Cesarean Section
Interventions: DRUG: Morphine|DRUG: Hydromorphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Play-based Motor-Cognitive Training for Improved Reading
Status: COMPLETED
Conditions: Reading
Interventions: BEHAVIORAL: Teaching involving whole-body movements|BEHAVIORAL: Teaching involving hand movements|BEHAVIORAL: Teaching involving minimal motor movements (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Colorectal Cancer and Pre-Cancerous Adenoma Non-Invasive Detection Test Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer|Advanced Adenocarcinoma|Adenoma Colon|Polyp of Colon
Interventions: DIAGNOSTIC_TEST: Colosense Stool Sample Collection Kit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Saphenous Vein Harvesting by Endoscopic Versus Open Conventional Methods
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: Endoscopic vein harvest|OTHER: Open vein harvest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose Study in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CTP-730|DRUG: Placebo for CTP-730
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve
Status: RECRUITING
Conditions: Superficial Bladder Cancer|Non-muscle Invasive Bladder Cancer With Carcinoma in Situ
Interventions: DRUG: EG-70 (phase 1)|DRUG: EG-70 (phase 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Precision Treatment of HR+ HER2- Advanced Breast Cancer Based on SNF Molecular Subtyping
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Fluzoparib|DRUG: Everolimus|DRUG: Fulvestrant|DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of HF-LED-RL in Fitzpatrick Skin Types I to III
Status: UNKNOWN
Conditions: Skin Diseases|Keloid|Scar|Fibrosis|Hypertrophic Skin
Interventions: DEVICE: HF-LED-RL Phototherapy|DEVICE: Mock Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Post Market Clinical Follow-Up Study for EVOLUTION® BIOFOAM® Tibia and EVOLUTION® CS/CR Porous Femur
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Osteoarthritis|Traumatic Arthritis of Knee|Avascular Necrosis|Degenerative Joint Disease of Knee|Rheumatoid Arthritis of Knee|Correction of Functional Deformity
Interventions: DEVICE: Primary Knee implants
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Wrist/Hand Splints and Tendon/Nerve Gliding Exercises for Carpal Tunnel Syndrome: A RCT
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: DEVICE: Splint fabricated by an OT versus an off-the-shelf splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument Intraoperatively
Status: COMPLETED
Conditions: Disorder of Middle Ear|Otosclerosis of Middle Ear|Cholesteatoma, Middle Ear
Interventions: DEVICE: PalpEar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: ctDNA-MRD Based Adjuvant Targeted Therapy for EGFR Positive Stage I Lung Adenocarcinomas
Status: UNKNOWN
Conditions: Adenocarcinoma of Lung
Interventions: DRUG: Furmonertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOCUS (Nifedipine GITS's Effect on Central Pressure Assessed by Applanation Tonometry)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Nifedipine (Adalat, BAYA1040) and Valsartan|DRUG: Nifedipine (Adalat, BAYA1040)|DRUG: Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beans/Bran Enriching Nutritional Eating For Intestinal Health Trial
Status: COMPLETED
Conditions: Colorectal Cancer Control and Prevention
Interventions: DIETARY_SUPPLEMENT: Placebo-Control Meals and Snacks|DIETARY_SUPPLEMENT: Cooked Navy Bean Powder Meals and Snacks|DIETARY_SUPPLEMENT: Rice Bran Meals and Snacks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Cerebral Regional Tissue Oxygen Saturation to Guide Oxygen Delivery in Preterm Neonates During Immediate Transition
Status: COMPLETED
Conditions: Preterm Infant|Brain Injuries|Birth Hypoxia
Interventions: OTHER: Control group|DEVICE: Study group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Randomized Trial to Evaluate the Usefulness of Mental Health e-Learning
Status: NOT_YET_RECRUITING
Conditions: Depression|Anxiety
Interventions: OTHER: Depression e-Learning A|OTHER: Depression e-Learning B|OTHER: Anxiety e-Learning A|OTHER: Anxiety e-Learning B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Aprepitant for Prevention of Acute and Delayed Nausea and Vomiting in Patients Receiving a High-emetogenic Dose of Cyclophosphamide for Peripheral Blood Stem Cells Harvesting
Status: UNKNOWN
Conditions: Nausea|Vomiting
Interventions: DRUG: Aprepitant, Palonosetron, Dexamethasone|DRUG: Placebo, Palonosetron, Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Centella Asiatica Selected Triterpenes (CAST) for Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathy
Interventions: DRUG: Centella asiatica selected triterpenes (CAST)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Study Investigating MK-8931 in Participants With Mild and Moderate Hepatic Insufficiency (MK-8931-016)
Status: COMPLETED
Conditions: Amnestic Mild Cognitive Impairment|Alzheimer's Disease|Prodromal Alzheimer's Disease
Interventions: DRUG: MK-8931
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study of the Safety and Efficacy of NAFT-500 in Tinea Pedis
Status: COMPLETED
Conditions: Tinea Pedis|Athlete's Foot
Interventions: DRUG: NAFT-500|DRUG: Placebo 2-weeks|DRUG: Naftin 1%|DRUG: Placebo 4-weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Cardiorespiratory Performance After Interval Exercise Training Prior to Hematopoietic Cell Transplantation
Status: COMPLETED
Conditions: Stem Cell Transplantation, Hematopoietic
Interventions: BEHAVIORAL: Interval Exercise Training (IET)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of AVI-4658 to Induce Dystrophin Expression in Selected Duchenne Muscular Dystrophy Patients
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: AVI-4658 (Eteplirsen)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of AL-38583 Ophthalmic Solution 0.05%, 0.010% Versus AL-38583 Vehicle for Dry Eye
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: AL-38583 ophthalmic solution 0.05%|DRUG: AL-38583 ophthalmic solution 0.10%|DRUG: AL-38583 vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Continuing Lamivudine Versus Switching to Entecavir in Patients Who Achieved Undetectable HBV DNA
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Entecavir|DRUG: Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Broad Spectrum HPV Vaccine Dose Ranging Study (V502-001)
Status: COMPLETED
Conditions: HPV|Cervical Cancer|Premalignancy Anogenital Warts
Interventions: BIOLOGICAL: Comparator: Gardasil|BIOLOGICAL: Comparator: octavalent HPV Vaccine - dose formulation 1|BIOLOGICAL: Comparator: octavalent HPV Vaccine - dose formulation 2|BIOLOGICAL: Comparator: octavalent HPV Vaccine - dose formulation 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Dry Needling Plus Vibration on Myofascial Trigger Points in Individuals With Nonspecific Low Back Pain
Status: NOT_YET_RECRUITING
Conditions: Low Back Pain|Dry Needling|Electrolysis|Trigger Points
Interventions: OTHER: Dry Needling with Vibration|OTHER: Conventional Dry Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization Of the Intestinal Microbiome Evolution After Kidney Transplant Donation or Receipt
Status: TERMINATED
Conditions: Renal Transplant
Interventions: OTHER: Stool Specimen Collection|OTHER: Anal Swab Sampling|OTHER: Short Diet Assessment (SDA)|OTHER: NHANES Dietary Screener Questionnaire (DSQ)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Adding or Not Liposomal Transcrocetin (L-TC) With Concomitant HypoFractionated Radiation ThErapy and TEmozolomide in Newly Diagnosed GLioblastoma (GBM) Patients
Status: NOT_YET_RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: Administration of L-TC|OTHER: Radiotherapy plus Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Horner's SD After Thoracic Epidural Block
Status: COMPLETED
Conditions: Horner's Syndrome
Interventions: PROCEDURE: thoracic epidural anesthesia|PROCEDURE: mastectomy|DRUG: Ropivacaine|DRUG: Propofol|DRUG: Fentanyl
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of Cardiac Resynchronization Therapy in Patients With Wide QRS and Non-specific Intraventricular Conduction Delay: a Randomized Trial
Status: UNKNOWN
Conditions: Heart Failure
Interventions: OTHER: CRT implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Gender/Sex & CUD Remission
Status: RECRUITING
Conditions: Cannabis Use Disorder, Mild|Cannabis Use Disorder, Moderate|Cannabis Use Disorder, Severe
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy (CBT4CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Tirzepatide (LY3298176) in Adult Participants With Type 2 Diabetes Switching From Dulaglutide (SURPASS-SWITCH)
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Tirzepatide|DRUG: Dulaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Cytoreductive Nephrectomy in Metastatic Renal Cell Carcinoma in Immuno-oncology Era: SEVURO-CN Trial
Status: RECRUITING
Conditions: Kidney Cancer|Clear Cell Renal Cell Carcinoma Metastatic|Synchronous Neoplasm
Interventions: PROCEDURE: Cytoreductive nephrectomy±metastasectomy|PROCEDURE: Cytoreductive nephrectomy±metastasectomy|OTHER: Human-derived materials sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GM1 Prophylaxis for WBRT Related Cognitive Dysfunction
Status: TERMINATED
Conditions: Brain Metastases|Radiotherapy Side Effect|Cognitive Impairment|Gangliosidosis, GM1|Breast Cancer
Interventions: DRUG: Monosialotetrahexosyl ganglioside (GM1)|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Plaque Psoriasis
Status: COMPLETED
Conditions: Pruritus|Psoriasis
Interventions: DRUG: 5 mg Serlopitant Tablets|DRUG: Matching Placebo Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rectal Sensory Training - A Study of Two Techniques
Status: COMPLETED
Conditions: Rectal Hyposensitivity|Constipation
Interventions: PROCEDURE: Syringe Conditioning|PROCEDURE: Barostat Conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Time Restricted Fasting and Aerobic Exercise Interventions Among Sedentary Adults
Status: COMPLETED
Conditions: Sedentary; Aging
Interventions: BEHAVIORAL: Aerobic Exercise|BEHAVIORAL: Time Restricted Fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Laboratory Study in Predicting Tumor Response to Chemotherapy in Patients With Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
Status: UNKNOWN
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: OTHER: flow cytometry|OTHER: immunohistochemistry staining method
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Non-Invasive Cervical Cancer Radiotherapy for Stage IB-IVB
Status: WITHDRAWN
Conditions: Cervical Cancer|Cervical Cancer Stage|Cervical Cancer Stage IB2|Cervical Cancer Stage IB1|Cervical Cancer Stage I|Cervical Cancer Stage IB|Cervical Cancer Stage II|Cervical Cancer Stage IIa|Cervical Cancer, Stage IIB|Cervical Cancer, Stage III|Cervical Cancer Stage IIIB|Cervical Cancer Stage IIIA|Cervical Cancer Stage Iv|Cervical Cancer Stage IVA|Cervical Cancer Stage IVB
Interventions: RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Pharmacokinetics and the Pharmacodynamics of Different Dry Powder Inhalation Formulations of AZD3199 in Patients With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: AZD3199|DRUG: AZD3199|OTHER: AZD3199 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Functional Inspiratory Muscle Training Versus Inspiratory Muscle Training
Status: ENROLLING_BY_INVITATION
Conditions: Respiratory Muscles|Stroke
Interventions: OTHER: Functional Inspiratory Muscle Training|OTHER: Inspiratory Muscle Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Peritoneal Carcinomatosis From Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer|Peritoneal Carcinomatosis
Interventions: PROCEDURE: Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy procedure|PROCEDURE: Cytoreductive surgery alone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused ABBV-383 in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed/Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Relapsed/Refractory Multiple Myeloma
Interventions: DRUG: ABBV-383|DRUG: Dexamethasone|DRUG: Lenalidomide|DRUG: Pomalidomide|DRUG: Nirogacestat|DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Once Daily Elvucitabine Versus Lamivudine in Participants With a Documented M184V Mutation
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Elvucitabine|DRUG: Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotic Intervention for Occasional Constipation
Status: NOT_YET_RECRUITING
Conditions: Gut Function|Occasional Constipation
Interventions: DIETARY_SUPPLEMENT: Probiotics|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Psilocybin on Shared Experience
Status: NOT_YET_RECRUITING
Conditions: Disorders of Consciousness|Psychedelic Experiences
Interventions: DRUG: Psilocybin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess the Safety and Efficacy of OCU400 for Retinitis Pigmentosa and Leber Congenital Amaurosis
Status: RECRUITING
Conditions: Retinitis Pigmentosa|Leber Congenital Amaurosis
Interventions: DRUG: OCU400 Low Dose|DRUG: OCU400 Med Dose|DRUG: OCU400 High Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tracheostomized COPD Patients and Non Invasive Mechanical Ventilation
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: OTHER: WBC, biomarkers, TBA, chest X ray|OTHER: WBC, biomarkers, TBA, chest X ray
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: GSK1605786A in the Maintenance of Remission in Subjects With Crohn's Disease
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: DRUG: GSK1605786A|DRUG: Placebo|DRUG: GSK1605786A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arnica Montana and Bellis Perennis for Prevention of Seroma After Mastectomy
Status: COMPLETED
Conditions: Seroma
Interventions: DRUG: Homeopathic Medication|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effectiveness of the Care Programme for the Last Days of Life
Status: COMPLETED
Conditions: Older Patients Dying in Acute Geriatric Hospital Wards
Interventions: OTHER: Care Programme for the Last Days of Life
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of GM1 in Prevention of Taxanes Induced Neurotoxicity in Operable Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Ganglioside-monosialic acid|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Vaginal Cuff Closure in Robotic Hysterectomy
Status: COMPLETED
Conditions: Complications of Medical Care
Interventions: DEVICE: V-lock suture|DEVICE: Vicryl Suture|DEVICE: Lapra-Ty II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Potential Role of Ga-68-PSMA in Staging, Restaging and Monitoring Response in Primary Liver Cancer: Comparison With F-18-FDG
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma (HCC)
Interventions: RADIATION: Ga-68-PSMA scan, and PET -CT F-18-FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: STAND Community Trial
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: STAND (Behavior Therapy + Motivational Interviewing)|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Effects of Dextrose Solutions on the Course of Labor
Status: COMPLETED
Conditions: Labor
Interventions: DRUG: D5NS|DRUG: D10NS|DRUG: NS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Case Study of Nivolumab for Relapsed/Refractory Primary Central Nervous System Lymphoma
Status: UNKNOWN
Conditions: Refractory Central Nervous System Lymphoma|Relapsed Primary Central Nervous System Lymphoma|Primary Central Nervous System Lymphoma
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anecortave Acetate Injection to Treat Steroid-responsive Intraocular Pressure Increase in Cornea Transplant Patients
Status: TERMINATED
Conditions: Transplant|Intraocular Pressure
Interventions: DRUG: anecortave acetate|DRUG: 30 mg anecortave acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of Clinical Assessment Technique Using Multi-radiotracer PET/MR in Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer Recurrent|Stage II Prostate Carcinoma|Stage III Prostate Carcinoma
Interventions: DEVICE: PET/MR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Osteopathic Otitis Media Research Study
Status: COMPLETED
Conditions: Otitis Media With Effusion
Interventions: PROCEDURE: osteopathic manipulative medicine (OMM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Psychological Influences on Postoperative Recovery
Status: COMPLETED
Conditions: Care, Postoperative|Pain, Postoperative|Surgical Procedures, Operative|Otorhinolaryngologic Surgical Procedures|Tonsillectomy|Adenoidectomy
Interventions: BEHAVIORAL: Preoperative Preparation Program (Child Life Specialist)|DRUG: Midazolam|BEHAVIORAL: Parental Presence during Induction of Anesthesia|OTHER: PPIA preparation program PLUS Midazolam premedication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study on Using Cell-Free Tumor DNA (ctDNA) Testing to Decide When to StartRoutine Treatment in People With Human Papilloma Virus (HPV)- Associated Oropharynx Cancer (OPC)
Status: RECRUITING
Conditions: HPV|Oropharynx Cancer|HPV-Related Carcinoma|HPV-Related Malignancy|HPV Positive Oropharyngeal Squamous Cell Carcinoma
Interventions: DIAGNOSTIC_TEST: HPV ctDNA Assay|DIAGNOSTIC_TEST: MRI Studies|BEHAVIORAL: EORTC QLQ H&N 35 and C30|BEHAVIORAL: MDADI-HN|BEHAVIORAL: COST-FACIT|RADIATION: Intensity-Modulated Radiation Therapy (Arm A)|COMBINATION_PRODUCT: Chemoradiation (Arm B)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Use of the "Game-Ready" Splint for Better Recovery in Primary Total Shoulder Arthroplasty
Status: RECRUITING
Conditions: Shoulder Osteoarthritis
Interventions: DEVICE: shoulder arthroplastis|DEVICE: shoulder arthroplastis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bevacizumab and Lomustine for Recurrent GBM
Status: COMPLETED
Conditions: Glioblastoma Multiforme|Cognition Disorders|Disability Evaluation
Interventions: BIOLOGICAL: bevacizumab|DRUG: lomustine|GENETIC: DNA methylation analysis|OTHER: laboratory biomarker analysis|PROCEDURE: cognitive assessment|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alpha Radiation Emitters Device for the Treatment of Primary and Recurrent Squamous Cell Carcinoma of the Vulva (DaRT).
Status: NOT_YET_RECRUITING
Conditions: Carcinoma of the Vulva|Recurrent Carcinoma of the Vulva
Interventions: DEVICE: DaRT seeds
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trifluridine/Tipiracil Combined With Oxaliplatin and Bevacizumab Versus XELOX Plus Bevacizumab in mCRC
Status: RECRUITING
Conditions: First-line Treatment|Advanced Colorectal Cancer
Interventions: DRUG: Trifluridine/Tipiracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Vein Isolation Using Stereotactic Radiotherapy System for the Treatment of Refractory Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: RADIATION: Stereotactic Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety, Tolerability, Pharmacokinetic of Thrv-1268
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: THRV-1268|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate Safety, Tolerability, and Preliminary Effect of the GEN1053 Antibody on Malignant Solid Tumors as Monotherapy
Status: TERMINATED
Conditions: Solid Tumor, Adult
Interventions: BIOLOGICAL: GEN1053
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact IPT With Sulfadoxine-pyrimethamine or Sulfadoxine-pyrimethamine Plus Piperaquine in Schoolchildren
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Sulfadoxine-pyrimethamine|DRUG: Piperaquine|DRUG: Albendazole|DRUG: Praziquantel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION