pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: SPIRIT PRIME Clinical Trial
Status: COMPLETED
Conditions: Myocardial Ischemia|Coronary Artery Stenosis|Coronary Disease|Coronary Artery Disease|Coronary Restenosis
Interventions: DEVICE: Core size Xience Prime|DEVICE: Xience Prime Long Lesion (LL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Muscle Fatigue and Kinesio Taping on Shoulder Position Sense
Status: COMPLETED
Conditions: Fatigue|Proprioception
Interventions: OTHER: Kinesio taping with tension|OTHER: Kinesio taping without tension|OTHER: Fatigue protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: DRV/r + RPV QD: Efficacy and Toxicity Reduction
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: RPV + DRV/r|DRUG: continue the PI/r-containing HAART.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PD-1 Blockade Combined With De-intensification Radical Chemoradiotherapy in Nasopharyngeal Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: PD-1 blocking antibody|DRUG: Gemcitabine|DRUG: Cisplatin (80mg/m2)|DRUG: Cisplatin (100mg/m2)|RADIATION: Intensity-modulated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Counteracting Learned Non-use Through Augmented Visuomotor Feedback in Virtual Reality (RGS)
Status: COMPLETED
Conditions: Hemiparesis
Interventions: BEHAVIORAL: Reinforcement-Induced Movement Therapy (RIMT)|BEHAVIORAL: VR-based motor rehabilitation in RGS without augmented feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: tVNS in Children With Prader-Willi Syndrome
Status: WITHDRAWN
Conditions: Prader-Willi Syndrome|Social Behavior
Interventions: DEVICE: tVNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of A Lyophilized Purified Human Diploid Cell Rabies Vaccine .
Status: COMPLETED
Conditions: Adverse Effect and Immunogenicity of Vaccine
Interventions: BIOLOGICAL: Human diploid cell rabies vaccine (Minhai Biothechnology Co., Ltd)|BIOLOGICAL: Human diploid cell rabies vaccine (Minhai Biothechnology Co., Ltd)|BIOLOGICAL: Human diploid cell rabies vaccine (Chengdu Kanghua Biological Products Co., Ltd.)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the GRIP Influenza and SARS-CoV-2 POC Assays
Status: COMPLETED
Conditions: COVID-19|Influenza
Interventions: DEVICE: GRIP Electronic Diagnostic Chip|DIAGNOSTIC_TEST: Laboratory-based nucleic acid amplification tests (NAATs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cardioprotective Activities Of Whole Eggs On Vascular Endothelial Function In Prediabetic Adults
Status: COMPLETED
Conditions: Prediabetes|Cardiovascular Disease
Interventions: OTHER: Glucose (100g)|OTHER: Glucose (75g)|OTHER: Whole Eggs|OTHER: Egg Whites|OTHER: Egg Yolks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Relative Bioavailability and Safety of Different Formulations of AZD4831 in Fasted State in Healthy Volunteers.
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: AZD4831
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Followed by gp100 Lymphocytes and Aldesleukin to Treat Melanoma
Status: COMPLETED
Conditions: Skin Cancer|Metastatic Melanoma
Interventions: DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiovagal Baroreflex Deficits Impair Neurovascular Coupling and Cognition in POTS
Status: COMPLETED
Conditions: Postural Orthostatic Tachycardia Syndrome (POTS)|POTS|Orthostatic Intolerance
Interventions: DRUG: Pyridostigmine|DRUG: Digoxin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pilot Study to Evaluate Safety and Efficacy of CigRx™ in Smokers
Status: COMPLETED
Conditions: Smoking|Tobacco Use Disorder
Interventions: DIETARY_SUPPLEMENT: CigRx Lozenge|OTHER: Tobacco Lozenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy, and Patient Preference of Split-Dose Crystalline Lactulose as a Preparation for Colonoscopy in Adults
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: Crystalline Lactulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PermeaDerm® vs. Mepilex-Ag® in Promoting Healing of Partial-thickness Burn Wounds
Status: WITHDRAWN
Conditions: Partial-thickness Burn
Interventions: DEVICE: PermeaDerm|DEVICE: Mepilex Ag
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of 2 Laryngoscopes for Endotracheal Intubation in Children Younger Than 2 Years Old
Status: COMPLETED
Conditions: Endotracheal Intubation
Interventions: DEVICE: Endotracheal intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: CiPA Phase 1 ECG Biomarker Validation Study
Status: COMPLETED
Conditions: Drug-induced QT Prolongation|Pharmacokinetics|Pharmacodynamics
Interventions: DRUG: Ranolazine|DRUG: Verapamil|DRUG: Lopinavir / Ritonavir|DRUG: Chloroquine|DRUG: Placebo|DRUG: Dofetilide and Diltiazem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Empagliflozin on Cardiac Structure in Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Diabetes|Cardiovascular Disease
Interventions: DRUG: Empagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treat Oral Lichen Planus
Status: COMPLETED
Conditions: Oral Lichen Planus
Interventions: OTHER: Chamaemelum nobile 2%|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: G1T48, an Oral SERD, Alone and in Combination With Palbociclib in ER-Positive, HER2-Negative Advanced Breast Cancer
Status: COMPLETED
Conditions: Carcinoma, Ductal, Breast|Breast Cancer Female|Breast Neoplasm|Breast Cancer|Metastatic Breast Cancer|Advanced Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: G1T48|DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digital Perineal Massage and Pelvic Floor Muscle Exercise During Pregnancy for Prevention of Perineal Laceration
Status: COMPLETED
Conditions: Delivery; Injury, Maternal
Interventions: OTHER: perineal massage program|OTHER: Pelvic floor muscle exercise program|OTHER: Educational pelvic floor dysfunction prevention program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Efficacy Between Two Myopia Control Lenses
Status: ACTIVE_NOT_RECRUITING
Conditions: Myopia
Interventions: DEVICE: Myopia Control Lens-1 (MCL1)|DEVICE: Myopia Control Lens-2 (MCL2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-blinded Evaluation of Safety and Efficacy of Hylaform and Hylaform Plus Compared to Zyplast.
Status: COMPLETED
Conditions: Facial Wrinkles
Interventions: DEVICE: Hylaform, Hylaform Plus (hylan B gel)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Estradiol and Testosterone Subdermal Implants for Menopause Treatment (ESTIME)
Status: NOT_YET_RECRUITING
Conditions: Menopause|Testosterone Deficiency|Estrogen Deficiency
Interventions: DRUG: testosterone pellet (100 mg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imatinib Versus Imatinib and Peg-Interferon in Patients With Ph+ CML and Complete Cytogenetic Response After Imatinib Therapy
Status: UNKNOWN
Conditions: Leukemia, Myeloid, Philadelphia-Positive
Interventions: DRUG: Pegylated Interferon and Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Buried Intramedullary K-wire Fixation Compared With Plate and Screw Fixation for Metacarpal Fractures in Unstable Extra-Articular Metacarpal Fractures
Status: ENROLLING_BY_INVITATION
Conditions: Metacarpal Fracture
Interventions: PROCEDURE: Buried Intramedullary K-wire Fixation|PROCEDURE: Plate and Screw Fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a GLP-1 Receptor Agonist on Functional Activation and Connectivity of the Brain
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Lixisenatide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Guo's Aortic Arch Reconstruction: The First in Man Study of WeFlow-Arch Modular Embedded Branch Stent Graft System
Status: COMPLETED
Conditions: Aortic Arch; Aneurysm, Dissecting
Interventions: DEVICE: WeFlow-Ach Moduler Embedded Branch Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of the Potent Cytochrome P-450 3A4 (CYP3A4) Inhibitor Itraconazole on the Pharmacokinetics (PK) of TAK-954 in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: TAK-954|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Calcium Concentration in Bicarbonate Hemodialysis (HD)
Status: COMPLETED
Conditions: Calcium Mass Balances and Serum Calcium Profiling in hd Patients
Interventions: OTHER: Dialysate calcium concentration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Decitabine/Cedazuridine (DEC-C) in Combination With Nivolumab for Patients With Mucosal Melanoma
Status: RECRUITING
Conditions: Malignant Melanoma
Interventions: COMBINATION_PRODUCT: Oral Decitabine/Cedazuridine (DEC-C) in Combination with Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Substituting SMSs for Provider-delivered Care to Improve Alcohol Use Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Alcohol Use Disorder, Mild|Alcohol Use Disorder, Moderate
Interventions: BEHAVIORAL: mhGAP-Remote|BEHAVIORAL: mhGAP-Standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Effects of Exenatide on Body Weight in Non-Diabetic, Obese Patients
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: exenatide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Immunogenicity of an Adenovirus-based Tuberculosis Vaccine
Status: TERMINATED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: Ad5Ag85A|BIOLOGICAL: Ad5Ag85A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: LDL Cholesterol TARGETs in OLDer Patients (Age≥75 Years) With ASCVD (TARGET OLD)
Status: RECRUITING
Conditions: Atherosclerotic Cardiovascular Disease|Older Patients|LDL Cholesterol
Interventions: PROCEDURE: Achieving a Target LDL-C level of 25mg/dL≤ LDL-C<70mg/dL|PROCEDURE: Achieving a Target LDL-C level of 70mg/dL≤ LDL-C<100mg/dL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of the Effect of Different Categories of Adhesive System
Status: UNKNOWN
Conditions: Dental Caries
Interventions: PROCEDURE: Dental restoration|PROCEDURE: 3 step ER|PROCEDURE: 2 step ER|PROCEDURE: 2 step SE|PROCEDURE: 1 step SE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Anodal Transcranial Direct Current Stimulation (tDCS) Over the Right-hemisphere on Picture Naming in Chronic Aphasia
Status: COMPLETED
Conditions: Aphasia
Interventions: DEVICE: tDCS stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Gemcitabine Plus Bosutinib for Patients With Resected Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine, Bosutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Evaluate the Use of Smart Adherence Technology to Measure Lumacaftor/Ivacaftor Adherence in CF Subjects Homozygous for the F508del CFTR Mutation
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DRUG: LUM/IVA|DEVICE: activated smart device|DEVICE: de-activated smart device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of IDN-6556 in Subjects With Liver Cirrhosis
Status: COMPLETED
Conditions: Liver Cirrhosis|Hepatic Cirrhosis
Interventions: DRUG: IDN-6556|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dornase Alfa for ARDS in Patients With Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2)
Status: COMPLETED
Conditions: SARS-CoV 2|ARDS
Interventions: DRUG: Dornase Alfa Inhalation Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: IMRT Followed by Pembrolizumab in the Adjuvant Setting in Anaplastic Cancer of the Thyroid (IMPAACT): Phase II Trial Adjuvant Pembrolizumab After IMRT in ATC
Status: RECRUITING
Conditions: Thyroid
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epidural Nalbuphine Versus Dexmedetomidine as Adjuvants to Bupivacaine in Lower Limb Surgeries
Status: COMPLETED
Conditions: Lower Limb Surgeries
Interventions: DRUG: normal saline|DRUG: Dexmedetomidine|DRUG: Nalbuphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Intravenous (IV) MOA-728 for the Treatment of Postoperative Ileus (POI) in Participants After Ventral Hernia Repair
Status: COMPLETED
Conditions: Ileus
Interventions: DRUG: MOA-728|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cranberry Juice in the Prevention of Urinary Tract Infections in Children
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: BIOLOGICAL: Cranberry juice|BIOLOGICAL: Placebo juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Inclisiran for Participants With Atherosclerotic Cardiovascular Disease and Elevated Low-density Lipoprotein Cholesterol
Status: COMPLETED
Conditions: ASCVD|Elevated Cholesterol
Interventions: DRUG: Inclisiran Sodium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Narrow Band Imaging Colon Polyp Study
Status: COMPLETED
Conditions: Adenomatous Polyp|New Imaging Techniques in Colonoscopy
Interventions: PROCEDURE: standard of care colonoscopy|PROCEDURE: colonoscopy|PROCEDURE: standard of care colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A mRUS Validation Study for Nail-treated Fractures of Long Bones and a TUS Exploratory Study for Nail and Plate-treated Fractures of Long Bones
Status: COMPLETED
Conditions: Delayed Union Fracture|CT-scan|X-Ray|Bone Fracture|Fracture Healing|Validation Studies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence Study of Vildagliptin From Gliptus 50 mg Tablet (EVA Pharma, Egypt) and Galvus 50 mg Tablet (NOVARTIS PHARMA, GERMANY)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Vildagliptin|DRUG: Vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.
Status: COMPLETED
Conditions: Endovascular Repair of Aortic Aneurysm|Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities
Interventions: DRUG: Sevoflurane|DRUG: Propofol|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Remifentanil for Mechanically Ventilated Patients in ICU
Status: UNKNOWN
Conditions: Analgesia
Interventions: DRUG: Remifentanil|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Interdisciplinary Multimodal Pain Therapy on Cerebral Connectivity in Chronic Pain Patients
Status: COMPLETED
Conditions: Chronic Pain, Interdisciplinary Multimodal Pain Therapy, Electroencephalography, Functional Connectivity
Interventions: OTHER: Interdisciplinary multimodal pain therapy (IMPT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Graded Exposure in Patients With Painful Diabetic Neuropathy
Status: COMPLETED
Conditions: Painful Diabetic Neuropathy|Diabetic Neuropathies, Painful|Neuralgia, Diabetic
Interventions: BEHAVIORAL: Graded Exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of RX-10045 in the Treatment of Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: RX-10045|DRUG: Vehicle for RX-10045
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Infection Prophylaxis Prior to Shoulder Surgery
Status: NOT_YET_RECRUITING
Conditions: Arthroplasty Shoulder|Periprosthetic Joint Infection
Interventions: DRUG: Chlorhexidine Gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Mojzisova Method on Pain, Menstrual Symptom and Insomnia in PD
Status: NOT_YET_RECRUITING
Conditions: Primary Dysmenorrhea
Interventions: OTHER: Mojzisova method|OTHER: Stretching exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Psoriasis Severity and Its Psychosocial Impact Using the Simplified Psoriasis Index (SPI), as Well as Long-term Safety, Tolerability and Efficacy of Secukinumab Administered Subcutaneously in Patients With Moderate to Severe Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Secukinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Infectivity, Safety and Immunogenicity of a Recombinant Live-Attenuated Respiratory Syncytial Virus Vaccine in RSV-Seronegative Infants 6 to 24 Months of Age
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: RSV LID ΔM2-2 1030s vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Reducing Silica Exposure Among Brick Kiln Workers in Nepal
Status: COMPLETED
Conditions: Silicosis
Interventions: DEVICE: N95 Respirator|DEVICE: Protective Eyewear|OTHER: Baseline Survey|OTHER: Design of Workshop|OTHER: Training Workshop Pilot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Fractional CO2 Laser Therapy Versus 4% Topical Lidocaine Gel for Dyspareunia in Breast Cancer Survivors
Status: UNKNOWN
Conditions: Dyspareunia
Interventions: DRUG: 4% Topical Lidocaine Gel|DEVICE: CO2RE fractional laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture Pilot Study for Cancer-related Cognitive Function
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage I Breast Cancer|Stage II Breast Cancer|Stage III Breast Cancer|Stage I Colorectal Cancer|Stage II Colorectal Cancer|Stage III Colorectal Cancer|Gynecologic Cancer|Stage I Gynecologic Cancer|Stage II Gynecologic Cancer|Stage III Gynecologic Cancer|Stage I Prostate Cancer|Stage II Prostate Cancer|Stage III Prostate Cancer
Interventions: OTHER: Acupuncture|OTHER: Sham Acupuncture|OTHER: 16 week waiting period + optional Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Multi-center Study a Single IV Infusion of Allogeneic MPCs in Patients With Rheumatoid Arthritis and Incomplete Response to at Least One TNFα Inhibitor
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Allogeneic Mesenchymal Precursor Cells|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Activity and Metformin Intervention in Obese Adolescents
Status: COMPLETED
Conditions: Obesity|Type 2 Diabetes
Interventions: DRUG: Metformin and standard exercise|DRUG: Metformin Intensive exercise|BEHAVIORAL: Placebo Standard exercise|BEHAVIORAL: Intensive exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Understanding Dopamine Mechanisms in Cocaine Addiction Using AMPT and Methylphenidate With [11C]RAC/[11C]PHNO PET
Status: TERMINATED
Conditions: Cocaine Dependence
Interventions: DRUG: Methylphenidate|DRUG: Alpha Methyl Para Tyrosine (AMPT)|OTHER: [11C]PHNO|OTHER: [11C]raclopride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of the Efficacy of ESTRATEST® H.S. Tablets in Relieving Menopausal Symptoms in Estrogenized Postmenopausal Women
Status: COMPLETED
Conditions: Menopause
Interventions: DRUG: esterified estrogens 0.625 mg and methyltestosterone 1.25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Intensity Modulated Accelerated Partial Breast Irradiation Before Surgery in Treating Older Patients With Hormone Responsive Stage 0-I Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Estrogen Receptor-positive Breast Cancer|Invasive Ductal Breast Carcinoma|Invasive Ductal Breast Carcinoma With Predominant Intraductal Component|Medullary Ductal Breast Carcinoma With Lymphocytic Infiltrate|Mucinous Ductal Breast Carcinoma|Papillary Ductal Breast Carcinoma|Progesterone Receptor-positive Breast Cancer|Stage IA Breast Cancer|Stage IB Breast Cancer|Tubular Ductal Breast Carcinoma
Interventions: RADIATION: accelerated partial breast irradiation|RADIATION: intensity-modulated radiation therapy|RADIATION: image-guided radiation therapy|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effects of Hepatic Impairment on the Pharmacokinetics of Miricorilant
Status: RECRUITING
Conditions: Non-alcoholic Steatohepatitis (NASH)
Interventions: DRUG: Miricorilant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction Chemotherapy Followed by IMRT or Concurrent Chemoradiotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Gemcitabine,Cisplatin|RADIATION: Intensity-modulated radiation therapy (IMRT)|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medication Intervention in Transitional Care to Optimize Outcomes & Costs for CKD & ESRD
Status: COMPLETED
Conditions: Chronic Kidney Disease|End-Stage Renal Disease
Interventions: OTHER: Medication Information Transfer Intervention|OTHER: Usual care for hospital discharge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Safety and Tolerability of WS016 in Healthy Chinese Volunteers
Status: COMPLETED
Conditions: Hyperkalemia
Interventions: DRUG: WS016 Single Dose(6g)|DRUG: WS016 Single Dose(12g)|DRUG: WS016 Single Dose(24g)|DRUG: WS016 Single Dose(36g)|DRUG: WS016 Single Dose(48g)|DRUG: SAD matching placebo|DRUG: WS016 Multiple Dose(12g)|DRUG: WS016 Multiple Dose(24g)|DRUG: WS016 Multiple Dose(48g)|DRUG: MAD matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multifaceted Intervention for Increasing Performance of CPR by Laypersons in Out-of-hospital Cardiac Arrest
Status: COMPLETED
Conditions: Cardiac Arrest
Interventions: OTHER: Multifaceted intervention including 3 components
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Ketamine and Etomidate During Rapid Sequence Intubation in Trauma Patients
Status: TERMINATED
Conditions: Trauma|Shock, Traumatic
Interventions: DRUG: Etomidate Injection 0.2 mg/kg|DRUG: Ketamine injection 2 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Night Time Use of Thiazide Diuretics for Improved Reduction in Stone Risk in Stone Formers With Elevated Urine Calcium
Status: COMPLETED
Conditions: Kidney Stones
Interventions: DRUG: chlorthalidone|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Prospective, Multicenter, Randomized, Blinded, Sham-controlled, Feasibility Study of Renal Denervation in Patients With Chronic Heart Failure
Status: RECRUITING
Conditions: Chronic Heart Failure|Cardio-Renal Syndrome
Interventions: PROCEDURE: Renal arteriography followed by renal denervation|PROCEDURE: Sham Renal arteriography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety, Tolerability and Pharmacokinetics of 1 Mg/Eye and 3 Mg/Eye Pegaptanib Sodium in Patients With Exudative Age-Related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: pegaptanib sodium (Macugen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Implantation of Gold Beads to Relieve Discomfort From Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: Implantation of gold beads around a knee through needles|PROCEDURE: Sham implantation: Insertion of needles around a knee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Fruit Smoothie Supplementation on Psychological Distress Among People Receiving Opioid Agonist Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Substance-Related Disorders
Interventions: DIETARY_SUPPLEMENT: Fruit smoothie
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypotension Probability Index in Anesthesia
Status: COMPLETED
Conditions: Hip Disease|Hypotension|Surgery|Anesthesia
Interventions: DEVICE: Hypotension probability index (HPI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bio-equivalence Study With Clinical Endpoints in the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Clindamycin Phosphate|DRUG: Clindamycin Phosphate RLD|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Macugen for Ischaemic Diabetic Macular Oedema
Status: COMPLETED
Conditions: Diabetic Macular Oedema
Interventions: DRUG: Intravitreal injection of pegaptanib sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Advance Care Planning Activity: Feasibility Testing for a Randomized Controlled Trial
Status: COMPLETED
Conditions: Chronic Disease|Caregivers
Interventions: BEHAVIORAL: Conversation card game|BEHAVIORAL: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized Trial of Intracoronary Reopro to Improve Coronary Microvascular Function
Status: UNKNOWN
Conditions: Myocardial Infarction|Coronary Artery Disease
Interventions: DRUG: Abciximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Mometasone Furoate for Persistent Asthma Previously Treated With Low-Dose Inhaled Glucocorticosteroids (ICS) (Study P06115)
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: SCH 32088 mometasone furoate (MF) metered-dose inhaler|DRUG: Placebo metered-dose inhaler BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: External-Beam Radiation Therapy, Capecitabine, and Sorafenib in Treating Patients With Locally Advanced Rectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: capecitabine|DRUG: sorafenib tosylate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulsatility Index, Vasomotor Reactivity and Leukoencephalopathy in Fabry Patients
Status: COMPLETED
Conditions: Fabry Disease
Interventions: DIAGNOSTIC_TEST: Transcranial Doppler (TCD) and Transcranial Color-Coded Duplex (TCCD) ultrasonography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metformin in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Trial Comparing UFT+PSK to UFT+LV in Stage IIB, III Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: Tegafur-uracil (UFT)|DRUG: Calcium folinate (LV)|DRUG: Krestin (PSK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monitoring Blood Flow and Metabolic Activity in Malignant Tissue of Head and Neck Region
Status: WITHDRAWN
Conditions: Squamous Cell Carcinoma of Head and Neck
Interventions: DEVICE: Lara Scan|DIAGNOSTIC_TEST: PET/CT Scan - Pre-treatment and Post-treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Cardiopulmonary Response to Conical-PEP Breathing During Exercise in Older People.
Status: UNKNOWN
Conditions: Aging
Interventions: DEVICE: a conical positive expiratory pressure device|OTHER: Constant work load cycling test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Complete Decongestive Therapy (CDT) for Treatment of Head and Neck Lymphedema
Status: WITHDRAWN
Conditions: Lymphedema|Oropharyngeal Cancer|Head and Neck Cancer|Oral Cancer
Interventions: OTHER: Follow -Up Visits|OTHER: Full CDT|OTHER: Modified CDT Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACOART Intracranial ISR Pilot:Intracranial DCB in the Treatment of Intracranial In-stent Restenosis
Status: RECRUITING
Conditions: Intracranial Atherosclerosis|Stroke
Interventions: DEVICE: drug (paclitaxel) coated balloon|DEVICE: PTA balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging Tau Deposition in the Brain of Elderly Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild Cognitive Impairment|Healthy|Alzheimer Disease|Neurocognitive Disorders
Interventions: OTHER: 18F-AV-1451 (Tau-PET tracer)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Methylphenidate for Apathy in Veterans With Parkinson's Disease
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease|Apathy
Interventions: BEHAVIORAL: Psychosocial intervention|DRUG: Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Naloxone, Hypoglycemia and Exercise
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Naloxone then placebo|DRUG: Placebo then Naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Efficacy of Uproleselan (GMI-1271) in Combination With Chemotherapy to Treat Relapsed/Refractory Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Uproleselan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bacterial Vaginosis Screening and Treatment to Reduce Infective Complications, Abortion and Preterm Delivery
Status: UNKNOWN
Conditions: Vaginosis, Bacterial|Abortion, Spontaneous|Premature Birth
Interventions: DEVICE: VS Sense
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Blood, Muscle and Exercise Responses to Sodium Bicarbonate Supplementation
Status: UNKNOWN
Conditions: Sports Nutritional Physiological Phenomena
Interventions: DIETARY_SUPPLEMENT: Sodium bicarbonate|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Powerlink Bifurcated Stent Graft Long-Term Follow-up Study
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: DEVICE: Powerlink infrarenal bifurcated stent graft delivery system|PROCEDURE: Open Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Varied Dialysate Bicarbonate Levels on Phosphate and Potassium Removal
Status: COMPLETED
Conditions: Chronic Dialysis Patients
Interventions: DRUG: Bicarbonate hemodialysis solution (low concentration)|DRUG: Bicarbonate hemodialysis solution (high concentration)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotics Before Cesarean Section on Postoperative Recovery in Pregnant Women
Status: RECRUITING
Conditions: Microbiota|Postoperative Recovery
Interventions: DRUG: Probiotic Blend Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Use of Lactobacillus Reuteri in Functional Constipation in Children
Status: TERMINATED
Conditions: Functional Constipation
Interventions: DIETARY_SUPPLEMENT: probiotic - Lactobacillus reuteri|OTHER: placebo - with no active ingredient
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Controlled, Single-blind Exploratory Study of the Efficacy and Safety of Wrist and Ankle Acupuncture Intervention on Nausea, Vomiting and Pain After Sleeve Gastric Surgery in Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Laparoscopic Sleeve Gastrectomy|Postoperative Nausea and Vomiting
Interventions: OTHER: Wrist and ankle acupuncture
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Colostrum Bovinum Supplementation in Endurance Athletes
Status: COMPLETED
Conditions: Sports Nutrition|Biochemical Markers|Exercise Performance|Aerobic Capacity|Supplementation
Interventions: DIETARY_SUPPLEMENT: Colostrum Bovinum supplementation|OTHER: Placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FDA018-ADC vs Investigator's Choice Chemotherapy to Treat Locally Advanced, Recurrent or Metastatic Triple-negative Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: FDA018-ADC|DRUG: Eribulin|DRUG: Capecitabine|DRUG: Gemcitabine|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Financial Incentives for Smoking Cessation Treatment Engagement
Status: COMPLETED
Conditions: Quitting Smoking
Interventions: OTHER: No Financial Incentive|OTHER: Financial Incentive (100 dollars)|OTHER: Financial Incentive (50 dollars)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of the Effectiveness of an Adapted Physical Activity Program in a Dedicated Structure to a Self-program in Patients in Chronic Phase of a Stroke
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: OTHER: Adapted physical activity program|OTHER: Adapted physical activity self-program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Intranasal Budesonide Aqueous Spray for Treatment of Rhinitis During Periods of High Airborne Pollution
Status: COMPLETED
Conditions: Rhinitis
Interventions: DRUG: Budesonide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Ability of Glulisine With Lispro to Control Type 1 Diabetes Mellitus in Children and Adolescents
Status: COMPLETED
Conditions: Diabetes Mellitus, Insulin-Dependent
Interventions: DRUG: Insulin glulisine|DRUG: insulin lispro|DRUG: insulin glargine|DRUG: NPH insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rifaximin Versus Norfloxacin in Spontaneous Bacterial Peritonitis
Status: UNKNOWN
Conditions: Spontaneous Bacterial Peritonitis
Interventions: DRUG: Rifaximin|DRUG: Norfloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Outcomes in Children With Pre-operative Residual Hearing
Status: ACTIVE_NOT_RECRUITING
Conditions: High Frequency Sensorineural Hearing Impairment|Hearing Disorders in Children
Interventions: DEVICE: Electric Acoustic Speech Processor: EAS fitting|DEVICE: Electric Acoustic Speech Processor: Electric only fitting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD20
Status: COMPLETED
Conditions: Hematopoietic/Lymphoid Cancer|Adult Acute Lymphoblastic Leukemia in Remission|B-cell Adult Acute Lymphoblastic Leukemia|B-cell Chronic Lymphocytic Leukemia|Prolymphocytic Leukemia|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Refractory Chronic Lymphocytic Leukemia|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Chronic Lymphocytic Leukemia|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Chronic Lymphocytic Leukemia|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma
Interventions: BIOLOGICAL: anti-CD19/20-CAR vector-transduced T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Obinutuzumab in Combination With GDP Chemotherapy in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin's
Interventions: DRUG: Obinutuzumab|DRUG: Gemcitabine|DRUG: Dexamethasone|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and PK of PXL770 in Healthy Male Subjects
Status: COMPLETED
Conditions: Metabolic Disease
Interventions: DRUG: PXL770|DRUG: Placebo|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel With or Without Ascorbic Acid in Treating Patients With Metastatic Prostate Cancer
Status: TERMINATED
Conditions: Hormone-Resistant Prostate Cancer|Metastatic Prostate Carcinoma|Stage IV Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: Ascorbic Acid|DRUG: Docetaxel|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|OTHER: Placebo|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT