pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Phase 1, Randomized, Placebo-Controlled, Ascending Cohort, Dose Escalation Study in Normal Healthy Volunteers
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: GSK3179106|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Management After Adductor Canal Block for Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Osteoarthritis|Knee Arthritis|Knee Arthropathy|Knee Pain Chronic
Interventions: DRUG: Ropivacaine 0.2% Injectable Solution|DRUG: 0.9%sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Subconjunctival Bevacizumab in Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Subconjunctival bevacizumab (Altuzan)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Speech Effects of a Speaking Valve Versus External Positive End-expiratory Pressure (PEEP) in Tracheostomized Ventilator-Dependent Neuromuscular Patients
Status: COMPLETED
Conditions: Tracheostomy|Mechanical Ventilation
Interventions: DEVICE: Passy Muir Valve|DEVICE: Positive end expiratory pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Remotely Delivered, Culturally Tailored Weight Loss Interventions Among Latina Breast Cancer Survivors
Status: NOT_YET_RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8
Interventions: BEHAVIORAL: Behavioral Dietary Intervention|BEHAVIORAL: Behavioral Intervention|PROCEDURE: Biospecimen Collection|OTHER: Dietary Intervention|OTHER: Educational Intervention|OTHER: Exercise Intervention|OTHER: Health Promotion and Education|OTHER: Internet-Based Intervention|OTHER: Interview|BEHAVIORAL: Lifestyle Counseling|OTHER: Medical Device Usage and Evaluation|OTHER: Medical Device Usage and Evaluation|OTHER: Nutritional Intervention|OTHER: Questionnaire Administration|BEHAVIORAL: Telephone-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Medically Unexplained Physical Ailments (Somatization Disorder)
Status: COMPLETED
Conditions: Somatoform Disorders
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glembatumumab Vedotin in Treating Patients With Metastatic or Locally Recurrent Uveal Melanoma
Status: COMPLETED
Conditions: Recurrent Uveal Melanoma|Stage IV Uveal Melanoma AJCC v7
Interventions: DRUG: Glembatumumab Vedotin|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HAIC of FOLFOX Plus Sorafenib vs HAIC of FOLFIRINOX Plus Sorafenib for Advcanced HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: Hepatic arterial infusion chemotherapy|DRUG: Folfox Protocol|DRUG: Sorafenib|PROCEDURE: Hepatic arterial infusion chemotherapy|DRUG: FOLFIRINOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effects of Balance Discs With Different Surfaces Used in Balance Education in Children With Cerebral Palsy on Proprioceptive Sense and Balance.
Status: RECRUITING
Conditions: Cerebral Palsy
Interventions: OTHER: Spiky balance disc|OTHER: Pediatric neurodevelopmental therapy|OTHER: smooth balance disc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Establishing Pressures at the EGJ During Diaphragmatic Breathing Using High-resolution Esophageal Manometry
Status: RECRUITING
Conditions: Gastroesophageal Reflux|Dysphagia|Esophageal Motility Disorders
Interventions: DIAGNOSTIC_TEST: diaphragmatic breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Study of a Software With the Gold Standard
Status: WITHDRAWN
Conditions: Abdominal Aortic Aneurysm (AAA)
Interventions: OTHER: Surgeons CT scan analysis|DEVICE: PRAEVAorta CT scan analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Pembrolizumab Added to the Standard First-Line Therapy of Cyclophosphamide, Bortezomib, and Dexamethasone (CyBorD) for NDMM NTE
Status: WITHDRAWN
Conditions: Multiple Myeloma
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Red Rice Yeast in Low-density Lipoprotein (LDL) Lowering: an Efficacy Study
Status: UNKNOWN
Conditions: Dyslipidemias|LDL Hyperlipoproteinemia
Interventions: DRUG: Red Rice Yeast Extract|DRUG: Statin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of the Pharmacokinetic Goldenseal-Metformin Interaction in Diabetic Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Interaction, Adverse Herb-Drug|Diabetes Mellitus, Type 2
Interventions: DRUG: Midazolam Hcl 1Mg/Ml Inj|DIETARY_SUPPLEMENT: Goldenseal (Hydrastis canadensis)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: DY001: Safety and Effectiveness of DYME as an Agent for Selective Staining of the Anterior Capsule During Cataract Surgery
Status: COMPLETED
Conditions: Mature Cataracts
Interventions: DRUG: DYME|DRUG: DYME
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk
Status: COMPLETED
Conditions: Prodromal Schizophrenia
Interventions: DRUG: Diazepam 5 Mg Oral Tablet|DRUG: Ascorbic Acid 50 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Concurrent Immunotherapy With Postoperative Radiotherapy in Intermediate/High Risk HNSCC Patients Unfit for Cisplatin: The IMPORT Study (IMPORT)
Status: UNKNOWN
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: RADIATION: postoperative radiotherapy|DRUG: JS001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of TheraSphere® Yttrium-90 Glass Microspheres for Primary and Metastatic Liver Tumors
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular|Liver Neoplasms
Interventions: DEVICE: yttrium Y 90 microspheres (TheraSphere®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Thrombin-containing Collagen-based Hemostatic Matrix
Status: UNKNOWN
Conditions: Pancreatic Tumor
Interventions: DRUG: flowable thrombin containing collagen hemostat matrix|DRUG: thrombin coated L-dopa contained collagen patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: CD19-targeted CAR T Cells for Patients With Relapsed or Refractory in B-cell Acute Lymphoblastic Leukemia
Status: RECRUITING
Conditions: Acute Lymphocytic Leukemia
Interventions: BIOLOGICAL: CD19-targeted Chimeric Antigen Receptor (CAR) T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect on Music Therapy on Quality of Recovery After Gynecological Laparoscopy
Status: COMPLETED
Conditions: Quality of Recovery After General Anesthesia|Post Operative Pain
Interventions: OTHER: music|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transplant Antibody-Mediated Rejection: Guiding Effective Treatments
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Transplant Rejection|Antibody-mediated Rejection
Interventions: DRUG: Rituximab|DRUG: Methylprednisolone|DRUG: Intravenous Immunoglobulin|PROCEDURE: Plasma Exchange
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Masitinib in Patients With Symptomatic Mild to Moderate COVID-19
Status: RECRUITING
Conditions: Covid19|SARS-CoV2 Infection|Coronavirus Disease 2019
Interventions: DRUG: Masitinib Mesylate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase Ⅲ Study of Hemay022 in Combination With AI In Advanced Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Hemay022+AI|DRUG: Lapatinib+Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study to Evaluate the Additivity of Trabodenoson to Latanoprost in Adults With Ocular Hypertension or Primary Open-Angle Glaucoma
Status: COMPLETED
Conditions: Primary Open-Angle Glaucoma (POAG)|Ocular Hypertension (OHT)
Interventions: DRUG: Trabodenoson|DRUG: Latanoprost|DRUG: Timolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Fecal Microbiota Transplantation for Chronic Intestinal Pseudo-obstruction
Status: COMPLETED
Conditions: Chronic Intestinal Pseudo Obstruction
Interventions: PROCEDURE: fecal microbiota transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CYP2B6 Polymorphisms in Methadone Disposition
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: IV racemic methadone HCl|DRUG: Oral racemic methadone HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Pelvic Floor Training in Male Chronic Pelvic Pain, Correlation Between Subjective and Objective Outcomes
Status: RECRUITING
Conditions: Chronic Pelvic Pain Syndrome|Chronic Prostatitis With Chronic Pelvic Pain Syndrome|Chronic Prostatitis|Pelvic Floor; Relaxation
Interventions: OTHER: Pelvic floor re-education using bio-feedback and home training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Effect of ARC-AAT Injection on Circulating and Intrahepatic Alpha-1 Antitrypsin Levels
Status: WITHDRAWN
Conditions: Alpha-1 Antitrypsin Deficiency
Interventions: DRUG: ARC-AAT Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Nasal Positive End Expiratory Pressure Valve to Dental Device as an Alternative Treatment for Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Adverse Effects
Interventions: DEVICE: nasal peep valve "Provent"
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Dapsone and Trimethoprim-Sulfamethoxazole in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
Status: COMPLETED
Conditions: Pneumonia, Pneumocystis Carinii|HIV Infections
Interventions: DRUG: Trimethoprim|DRUG: Sulfamethoxazole|DRUG: Dapsone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of ACY-1215 in Combination With Lenalidomide, and Dexamethasone in Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: ACY-1215|DRUG: lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kerecis Real-World Fish Skin Graft Registry
Status: ENROLLING_BY_INVITATION
Conditions: Wounds|Pressure Ulcer|Diabetic Foot Ulcer|Venous Leg Ulcer|Surgical Wound|Soft Tissue Reinforcement
Interventions: DEVICE: Kerecis Fish Skin Graft
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of CDP-Choline on Gating and Cognitive Deficits in First Episode Schizophrenia
Status: UNKNOWN
Conditions: First Episode Schizophrenia
Interventions: DIETARY_SUPPLEMENT: CDP-Choline|DIETARY_SUPPLEMENT: Cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Effects of Risperdal Consta on Ability to Benefit From Social Skills Training in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Risperdal Consta (drug)|BEHAVIORAL: Social Skills Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate Dietary Supplements to Maintain Gut Health During Travel
Status: RECRUITING
Conditions: Diarrhea
Interventions: DIETARY_SUPPLEMENT: Travelan®|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Randomized Study Comparing the Efficacy and Safety of Varenicline Tartrate to Placebo in Smoking Cessation When Subjects Are Allowed to Set Their Own Quit Date
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: placebo|DRUG: varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Simulation-based Neonatal Echocardiography Training (SimuEchoNeo)
Status: COMPLETED
Conditions: Simulation-based Training on Residents
Interventions: DIAGNOSTIC_TEST: TTE simulation-based medical training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Short-Term Study to Examine the Effects of ATHX-105 Phosphate on Weight Loss and Safety
Status: WITHDRAWN
Conditions: Obesity
Interventions: DRUG: ATHX-105 phosphate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MOTION, Safinamide in Early IPD, as add-on to Dopamine Agonist
Status: COMPLETED
Conditions: Idiopathic Parkinson's Disease
Interventions: DRUG: Safinamide (as add-on therapy)|DRUG: Safinamide (as add-on therapy)|DRUG: Safinamide (as add-on therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gamification in the Treatment of Spider Phobia
Status: RECRUITING
Conditions: Spider Phobia
Interventions: BEHAVIORAL: 7-day exposure therapy via self-developed app according to (Haberkamp et al., submitted)|BEHAVIORAL: Therapist-guided one-session online exposure therapy according to (Öst, 1989)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of a Computer Decision Support System to Treat Depression
Status: COMPLETED
Conditions: Depressive Disorder
Interventions: OTHER: Computerized Decision Support System for Depression (CDSS-D)|OTHER: Usual Care (UC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of Ublituximab + Umbralisib With or Without Bendamustine and Umbralisib Alone in Patients With Previously Treated Non-Hodgkins Lymphoma
Status: TERMINATED
Conditions: Diffuse Large B-Cell Lymphoma|Follicular Lymphoma|Marginal Zone Lymphoma|Mantle Cell Lymphoma|Small Lymphocytic Lymphoma
Interventions: BIOLOGICAL: Ublituximab|DRUG: Umbralisib|BIOLOGICAL: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Approaches of Delivering Local Dental Anesthesia on Pain Perception in Children.
Status: UNKNOWN
Conditions: Pain|Local Anesthetics|Epinephrine|Vibration
Interventions: DRUG: Topical anesthetic|DEVICE: Avent baby bottle warmer|DRUG: Sodium bicarbonate|DEVICE: Buzzy device|DRUG: Mepivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Strengthening Families Living With HIV in Kenya
Status: ACTIVE_NOT_RECRUITING
Conditions: ART|Hiv|Trust|Depression, Anxiety|PTSD|Adherence, Medication
Interventions: BEHAVIORAL: Kuja Pamoja - HIV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Skills to Enhance Positive Affect in Suicidal Adolescents
Status: COMPLETED
Conditions: Suicidal Ideation|Suicide, Attempted
Interventions: BEHAVIORAL: Positive Affect Skills Training|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Single Doses of ABT-072 in Japanese Healthy Male Adults
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: ABT-072|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Transfusion of Plasma on Endothelial During Liver Transplantation
Status: RECRUITING
Conditions: End Stage Liver DIsease|Liver Transplantation
Interventions: BIOLOGICAL: fresh frozen plasma|DIAGNOSTIC_TEST: blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Diet on Intestinal Microbiota and Obesity Markers in Adults
Status: COMPLETED
Conditions: Intestinal Microbiota|Blood Markers
Interventions: DIETARY_SUPPLEMENT: low meat high fibre|DIETARY_SUPPLEMENT: high meat low fibre
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Studies of Immune Responses to Orally Administered Vaccines in Developing Country
Status: COMPLETED
Conditions: Cholera|Typhoid
Interventions: DRUG: Placebo|DRUG: Placebo|OTHER: Control|DRUG: Zinc Sulphate|DRUG: Albendazole and Secnidazole|OTHER: Arsenic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Lactobacillus Reuteri Plus Vitamin D3 in Children With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DIETARY_SUPPLEMENT: Reuterin D3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy With Ex Vivo Generated Polyomavirus-Specific T-Cells
Status: COMPLETED
Conditions: Progressive Multifocal Leukoencephalopathy
Interventions: BIOLOGICAL: PyVST
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Study With GLPG3970 and Sulfasalazine in Adult, Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Sulfasalazine|DRUG: GLPG3970
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: In-Home Technology for Dementia Caregivers
Status: COMPLETED
Conditions: Dementia|Alzheimer's Disease|Frontotemporal Dementia
Interventions: DEVICE: In-home technology|DEVICE: Limited in-home technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination of Hyperthermia and Concurrent Chemoradiotherapy (CCRT) for Recurrent Head and Neck Cancer
Status: UNKNOWN
Conditions: Recurrent Head and Neck Cancer
Interventions: RADIATION: Radiation|DEVICE: Hyperthermia; Thermotron RF-8|DRUG: Cisplatin|DRUG: Taxotere
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Kovacaine Nasal Spray for Dental Anesthesia
Status: COMPLETED
Conditions: Dental Anesthesia Efficacy
Interventions: DRUG: 3% tetracaine HCL with 0.05% oxymetazoline HCL|DRUG: Lidocaine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment Adherence Intervention in Patients With Type 2 Diabetes and Comorbid Depression
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Depression
Interventions: BEHAVIORAL: Telephone Intervention Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Hericium Erinaceus Mycelium in Non-motor Symptoms of Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: DIETARY_SUPPLEMENT: Hericium erinaceus mycelium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Immune Checkpoint Inhibition in Combination With Radiation Therapy in Pancreatic Cancer or Biliary Tract Cancer Patients
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer|Metastatic Biliary Tract Cancer
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Doxycycline Monohydrate Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: To Determine Bioequivalence Under Fasting Conditions
Interventions: DRUG: doxycycline monohydrate|DRUG: doxycycline monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Evaluation of the Role of Mesenchymal Stem Cells in the Treatment of Graft Versus Host Disease
Status: UNKNOWN
Conditions: Graft vs Host Disease
Interventions: DRUG: Mesenchymal Stem Cell Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strategies and Treatments for Respiratory Infections &Amp; Viral Emergencies (STRIVE): Immune Modulation Strategy Trial
Status: RECRUITING
Conditions: COVID-19
Interventions: DRUG: abatacept infusion|DRUG: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: VIDAS® TBI Real Life Performance in Subjects With Mild Traumatic Brain Injury (mTBI)
Status: RECRUITING
Conditions: Mild Traumatic Brain Injury
Interventions: DIAGNOSTIC_TEST: VIDAS® TBI Test [GFAP and UCH-L1 assays]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sequence Towards Remission in Depression
Status: UNKNOWN
Conditions: Depression
Interventions: DRUG: escitalopram 10 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Cosmetic Benefit of a Skin Cream in Healthy Females With Mild to Advanced Photo-damaged Facial Skin Who Have Undergone a Glycolic Acid Facial Peel Procedure
Status: COMPLETED
Conditions: Skin Care
Interventions: OTHER: Test Product|OTHER: Cleanser|OTHER: Sunscreen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Incisional Hernia With Mesh-suture at Umbilical Trocar Site.
Status: RECRUITING
Conditions: Incisional Hernia of Anterior Abdominal Wall|Dehiscence Wound|Wound Infection
Interventions: DEVICE: duramesh suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Induction Chemotherapy Followed By Cetuximab and Radiation in HPV-Associated Resectable Stage III/IV Oropharynx Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer|Precancerous Condition
Interventions: BIOLOGICAL: cetuximab|RADIATION: intensity-modulated radiation therapy (IMRT)|DRUG: Paclitaxel|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of R1507 in Combination With Tarceva (Erlotinib) on Progression-Free Survival in Patients With Stage IIIb/IV Non-Small Cell Lung Cancer (NSCLC) Having Received Tarceva Monotherapy.
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: RG1507|DRUG: erlotinib [Tarceva]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Assessing the Safety, Efficacy, and Optimum Dosage of K-161 in Subjects With Moderate to Severe Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: K-161|OTHER: Placebo (Vehicle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Capability of PulmoVista 500 to Continuously Monitor Changes of Ventilation Over Time
Status: COMPLETED
Conditions: Mechanical Ventilation|Single-lung Ventilation|ARDS|ALI - Acute Lung Injury|Weaning From Ventilator
Interventions: DEVICE: Lung Monitoring with EIT device (PulmoVista 500)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tenotomy of Biceps' Long Head by Mini-optics in Consultation (Hyperambulatory): What Advantage Compared to the Operating Room?
Status: RECRUITING
Conditions: Shoulder Pain|Biceps Tendon Disorder
Interventions: PROCEDURE: Hyperambulatory tenotomy|PROCEDURE: Operating room tenotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the LensGen® Juvene® Intraocular Lens
Status: NOT_YET_RECRUITING
Conditions: Cataract|Presbyopia
Interventions: DEVICE: Juvene IOL|DEVICE: Tecnis® Monofocal (ZCB00, PCB00 or DCB00)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Double Blind Placebo-controlled, Parallel Group Study to Assess the Efficacy and Safety of Frovatriptan in the Acute Treatment of Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Frovatriptan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel, Carboplatin, and Panitumumab in Treating Patients With Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer
Interventions: BIOLOGICAL: panitumumab|DRUG: paclitaxel|DRUG: carboplatin|PROCEDURE: laboratory biomarker analysis|PROCEDURE: immunohistochemistry staining method
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of Brain Function Assessment Algorithm for mTBI/Concussion
Status: COMPLETED
Conditions: Brain Injuries, Traumatic|Concussion, Mild|Concussion, Severe|Concussion, Intermediate|Concussion, Brain
Interventions: DEVICE: BrainScope Ahead 300iP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Myeloablative Allogeneic Stem Cell Transplantation Using a Naive T-Cell Depleted Peripheral Blood Stem Cell Graft
Status: TERMINATED
Conditions: ALL|ANLL|MDS|NHL
Interventions: PROCEDURE: Naive T-cell Depleted Stem Cell Transplant|PROCEDURE: Stem Cell Transplant No Manipulation|DEVICE: Isolex device from Baxter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Alogliptin Used in Combination With Sulfonylurea in Participants With Type 2 Diabetes in Japan
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Alogliptin and glimepiride|DRUG: Alogliptin and glimepiride|DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cryoablation of Intercostal Nerves for Better Control of Postoperative Pain After Thoracic and Thoracoabdominal Open Surgery
Status: SUSPENDED
Conditions: Aneurysm
Interventions: PROCEDURE: Open thoracic (TAA) and thoracoabdominal aortic aneurysms repair (TAAA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: StereoTactic Ablative RadioTherapy of Cardiac Arrhythmias (START-CA)
Status: RECRUITING
Conditions: Cardiac Arrhythmia
Interventions: RADIATION: Stereotactic Ablative Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Post-Operative Sedation for Endovascular Thrombectomy
Status: RECRUITING
Conditions: Acute Ischemic Stroke|Endovascular Thrombectomy
Interventions: PROCEDURE: post-operative sedation|PROCEDURE: routine recovery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of HFB200301 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Gastric Cancer|Renal Cell Carcinoma|Melanoma|Sarcoma|Testicular Germ Cell Tumor|Cervical Cancer|Mesothelioma|Non Small Cell Lung Cancer|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: HFB200301|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Oral Messages on the Activity of Wrist and Finger Flexor Muscles
Status: COMPLETED
Conditions: Muscle|Communication|Activity, Motor
Interventions: BEHAVIORAL: Positive message - placebo|BEHAVIORAL: Negative message - nocebo|BEHAVIORAL: Neutral message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Electrical Stimulation of the Internal Capsule for Intractable Obsessive-compulsive Disorder (OCD)
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: Medtronic Activa Deep Brain Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduction of Dentine Hypersensitivity Using 8% Arginine Based Toothpaste and 8% Strontium Acetate Based Toothpaste (DH)
Status: UNKNOWN
Conditions: Dentin Hypersensitivity
Interventions: OTHER: 8% Arginine based toothpaste|OTHER: 8% strontium acetate based toothpaste|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First-in-Man, Dose-escalation Trial of c-Met Kinase Inhibitor EMD 1204831 in Subjects With Advanced Solid Tumors
Status: TERMINATED
Conditions: Solid Tumors
Interventions: DRUG: EMD 1204831
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Use of Antibiotics in Endoscopic Injection of Tissue Adhesive in Gastric Varices
Status: UNKNOWN
Conditions: Gastric Varices|Cirrhosis
Interventions: DRUG: Cefotiam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: B-cell Mature Non-Hodgkin's Lymphoma Treatment Protocol in Children and Adolescents 2021
Status: RECRUITING
Conditions: Non-hodgkin Lymphoma,B Cell|Burkitt Lymphoma|Primary Mediastinal Lymphoma|Primary CNS Lymphoma|Diffuse Large B-cell Lymphoma
Interventions: DRUG: Cyclophosphamide, Cytarabine, Dexamethasone, Etoposide, Ifosfamide, Methotrexate|DRUG: Cyclophosphamide, Cytarabine, Dexamethasone, Etoposide, Ifosfamide, Methotrexate, Vincristine|DRUG: Cyclophosphamide, Cytarabine, Dexamethasone, Doxorubicin hydrochloride, Etoposide, Ifosfamide, Methotrexate, vincristine|DRUG: Cyclophosphamide , Cytarabine, Dexamethasone, Doxorubicin hydrochloride, Etoposide, Ifosfamide, Methotrexate, Vincristine, Сarboplatine, CCNU/ BCNU, Melphalan, Idarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cigarette Harm Reduction With Electronic Cigarette Use
Status: WITHDRAWN
Conditions: Nicotine Dependence|Tobacco Toxicity|Nicotine Dependence, Cigarettes|Cardiovascular Risk Factor|Nicotine Withdrawal
Interventions: OTHER: SREC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sildenafil Added Effect in Dapoxetine Non-responding Mono-symptomatic Premature Ejaculation (PE)
Status: UNKNOWN
Conditions: Premature Ejaculation
Interventions: DRUG: Sildenafil 50 mg Oral Tablet and Dapoxitine 3mg Oral tablet|DRUG: Placebo oral tablet and Dapoxitine 3mg Oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Exercise Volume and Beta-cell Function in T2D The DOSE-EX Randomized Trial
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Type2 Diabetes|Diabetes Mellitus, Type 2|Type2 Diabetes Mellitus
Interventions: BEHAVIORAL: Exercise and diet|BEHAVIORAL: Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Sintilimab Plus Ramucirumab as First-line Treatment for G/EGJ Adenocarcinoma (ORIENT-106)
Status: TERMINATED
Conditions: Gastric Adenocarcinoma
Interventions: DRUG: Sintilimab|DRUG: Ramucirumab|DRUG: Cisplatin|DRUG: 5-fluorouracil|DRUG: Oxaliplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cemiplimab in Treating Patients With Recurrent and Resectable Stage II-IV Head and Neck Cutaneous Squamous Cell Cancer Before Surgery
Status: RECRUITING
Conditions: Recurrent Cutaneous Squamous Cell Carcinoma of the Head and Neck|Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck|Stage II Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8|Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8|Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8
Interventions: BIOLOGICAL: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intensity-Modulated Proton Therapy (IMPT) or TransOral Robotic Surgery (TORS) for the Treatment of Low-Risk Oropharynx Squamous Cell
Status: UNKNOWN
Conditions: Cancer of the Mouth|Oropharynx Squamous Cell Carcinoma
Interventions: BEHAVIORAL: Symptom Questionnaires|BEHAVIORAL: Dysphagia Inventory Questionnaire|BEHAVIORAL: Activity Bands
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Improving New Learning and Memory in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: memory retraining exercises|BEHAVIORAL: placebo control memory exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac ARrest : Brain OXymetry Depending on HYpothermia Depth
Status: COMPLETED
Conditions: Cardiac Arrest
Interventions: PROCEDURE: therapeutic hypothermia at 32 ° C|PROCEDURE: therapeutic hypothermia at 34 ° C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparing of the Clinical Outcome of Periodontal Accelerated Osteogenic Orthodontics With Horizontal or Vertical Releasing Incisions
Status: RECRUITING
Conditions: Malocclusion
Interventions: PROCEDURE: horizontally extending incision|PROCEDURE: vertical releasing incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carbidopa/Levodopa Combined With Behavioral Therapy for the Treatment of Cocaine Dependence
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: levodopa|DRUG: Placebo|BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Contingency Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Self-sampling of HPV to Screen for Cervical Cancer
Status: COMPLETED
Conditions: Human Papilloma Virus
Interventions: DIAGNOSTIC_TEST: Swab kit (COBAS HPV 4800 Assay -Evalyn brush)|DIAGNOSTIC_TEST: Clinician-collection of cervical sample for HPV testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effects of Black Tea Intake on Serum Lipids
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: Tea Treatment Group|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Creating an Optimized Technology-Based Weight Loss Program for Cardiac Rehabilitation Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases|Obesity
Interventions: BEHAVIORAL: Online Behavioral Weight Loss Program|BEHAVIORAL: Physical Activity Intervention|BEHAVIORAL: Bite Counter|BEHAVIORAL: Virtual Reality|BEHAVIORAL: Virtual Meetings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phototoxicity Test of Dapsone Gel in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: dapsone gel|DRUG: dapsone gel vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endotracheal Tubes for Prevention of Ventilator-associated Pneumonia
Status: COMPLETED
Conditions: Ventilator-acquired Pneumonia
Interventions: DEVICE: PVC ETT|DEVICE: PUC ETT|DEVICE: PUC-CASS ETT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: High Fat/High Calorie Trial in Amyotrophic Lateral Sclerosis
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DIETARY_SUPPLEMENT: Oxepa|DIETARY_SUPPLEMENT: Jevity 1.5|DIETARY_SUPPLEMENT: Jevity 1.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Reconstructive Microsurgery on the Clinical and Functional State of Laryngeal Stenosis
Status: UNKNOWN
Conditions: Larynx Disease|Laryngeal Stenosis
Interventions: DIAGNOSTIC_TEST: spirometry|RADIATION: MRI and CT|OTHER: Laryngoscopy|OTHER: electromyography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Response to 2 Induction Courses (12 Intravesical Instillations) of Bacillus Calmette-Guérin (BCG) for High Risk Superficial Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer|High Risk Superficial
Interventions: BIOLOGICAL: Bacillus Calmette-Guérin (BCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Molecular Findings in Patients With Cervical/Supraclavicular Metastasis From Non-small-cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Lung Cancer Metastatic
Interventions: PROCEDURE: Needle or forceps biopsy of cervical and/or supraclavicular lymph nodes|PROCEDURE: Needle, forceps or surgical biopsy of any lesion other than cervical and/or supraclavicular lymph nodes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Biodiversity Interventions for Assisted Living Centers
Status: ACTIVE_NOT_RECRUITING
Conditions: Nature, Human|Microbial Colonization|Well-Being, Psychological|Immune System and Related Disorders|Autism Spectrum Disorder|Visual Impairment
Interventions: OTHER: Rewilding
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemoimmunotherapy and Radiation in Pancreatic Cancer
Status: COMPLETED
Conditions: Locally Advanced Malignant Neoplasm
Interventions: DRUG: Tadalafil|DRUG: Gemcitabine|RADIATION: Radiation|PROCEDURE: Pancreaticoduodenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Very Low Calorie Diet vs Metabolic Surgery on Weight Loss and Obesity Comorbidities
Status: UNKNOWN
Conditions: Obesity, Morbid|Obesity|Diet, Healthy|Bariatric Surgery Candidate
Interventions: BEHAVIORAL: Very low calorie diet with Fortimel (Nutricia) supplementation|PROCEDURE: Metabolic Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study With Dual Therapy Including Lamivudine (300 mg QD) Plus Raltegravir (1200 mg QD) in Virologically Suppressed HIV-1 Infected Patients Experiencing Inconvenience, Toxicity, Negative Impact on Co-morbidities or Risk of Drug-drug Interactions With Their Current Regimen
Status: UNKNOWN
Conditions: HIV Seropositivity|HIV Infections|HIV-1-infection
Interventions: DRUG: Raltegravir|DRUG: Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fixation Versus Arthroplasty for Undisplaced Intracapsular Fractures
Status: UNKNOWN
Conditions: Hip Fractures|Undisplaced Intracapsular Hip Fracture
Interventions: DEVICE: Internal fixation|DEVICE: Cemented Hemiarthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carotid With Bivalirudin Angioplasty
Status: COMPLETED
Conditions: Carotid Artery Disease
Interventions: DEVICE: RX ACCULINK™ Carotid Stent System; RX ACCUNET™ Embolic Protection System; PercuSurge GuardWire® 3-6 Temporary Occlusion and Aspiration System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Inguinal Hernia Repair on Isokinetic Muscle Strength
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: PROCEDURE: lichtenstein|PROCEDURE: Kugel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of BP1001 in Combination With With Venetoclax Plus Decitabine in AML
Status: RECRUITING
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: BP1001 in combination with Ventoclax plus decitabine|DRUG: BP1001 plus decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study on the S-1 + Paclitaxel Chemotherapy for Unresectable Gastric Cancer
Status: UNKNOWN
Conditions: Surgically-Created Resection Cavity|Drug Safety
Interventions: DRUG: S-1 + Paclitaxel Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT