pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Sorafenib in Treating Patients With Refractory or Relapsed Acute Leukemia, Myelodysplastic Syndromes, or Blastic Phase Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Megakaryoblastic Leukemia|Adult Acute Monoblastic Leukemia|Adult Acute Monocytic Leukemia|Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With Maturation|Adult Acute Myeloid Leukemia With Minimal Differentiation|Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1|Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3-MLL|Adult Acute Myeloid Leukemia Without Maturation|Adult Acute Myelomonocytic Leukemia|Adult Acute Promyelocytic Leukemia With t(15;17)(q22;q12); PML-RARA|Adult Erythroleukemia|Adult Pure Erythroid Leukemia|Alkylating Agent-Related Acute Myeloid Leukemia|Blastic Phase|de Novo Myelodysplastic Syndrome|Previously Treated Myelodysplastic Syndrome|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndrome
Interventions: DRUG: Sorafenib Tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Hamstring Training in Different Modes on Stabilizing Knee Joints With Anterior Drawer Laxity
Status: COMPLETED
Conditions: Knee Instability
Interventions: OTHER: plate-loaded kneeling leg curl with internal rotation|OTHER: plate-loaded squat press|OTHER: plate-loaded kneeling leg curl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Extension Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis and Active Systemic Manifestations Manifestations and Response Characterization Study in Canakinumab Treatment-naïve Patients With Active SJIA With and Without Fever.
Status: COMPLETED
Conditions: Systemic Juvenile Idiopathic Arthritis
Interventions: DRUG: Canakinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Dehydroepiandrosterone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Wheelchair User Physical Activity Training Intervention to Enhance Cardiometabolic Health
Status: RECRUITING
Conditions: Physical Disability
Interventions: BEHAVIORAL: Intensity-controlled physical activity training (IPAT)|BEHAVIORAL: Education and Access (EA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First-line Therapy of Stage IV Colorectal Cancer
Status: COMPLETED
Conditions: Stage IV Colorectal Cancer
Interventions: DRUG: Oxaliplatin, Capecitabine, Bevacizumab, Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-selective Beta Blockers Versus EVL for Primary Prophylaxis of Esophageal Variceal Bleeding in Patients With Hepatocellular Carcinoma With Portal Vein Tumour Thrombosis.
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma With Portal Vein Thrombosis
Interventions: PROCEDURE: Endoscopic Variceal Ligation|DRUG: Carvedilol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Explorative Trial Evaluating the Effect of LEO 32731 Cream in Adults With Mild to Moderate Atopic Dermatitis (AD)
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: LEO 32731 cream|DRUG: LEO 32731 cream vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Tests in Supra-Esophageal Gastroesophageal Reflux Disease (SE-GERD)
Status: RECRUITING
Conditions: Gastroesophageal Reflux
Interventions: DEVICE: externally applied cricoid cartilage pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Thromboembolic Risk Screening in Patients With Cancer and COVID-19
Status: COMPLETED
Conditions: Neoplasms Malignant|Covid19|Thromboembolism
Interventions: DIAGNOSTIC_TEST: Peripheral venous ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Safety and Effectiveness of ABT-510 Plus Combination Chemotherapy in Subjects With Non-Small Cell Lung Cancer (NSCLC)
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: ABT-510/Thrombospondin-1 mimetic|DRUG: Carboplatin/Taxol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Ketoprofen Versus Placebo in Patients With Ankle Sprain
Status: COMPLETED
Conditions: Ankle Sprain
Interventions: DRUG: Ketoprofen gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Retinal Imaging in Neurodegenerative Disease
Status: RECRUITING
Conditions: Alzheimer's Disease|Mild Cognitive Impairment|Parkinson's Disease|Multiple Sclerosis|Huntington Disease|Lewy Body Dementia|Frontotemporal Dementia|Amyotrophic Lateral Sclerosis (ALS)|APOE-4 Positive|Traumatic Brain Injury|Concussion|Post-Traumatic Stress Disorder|Down Syndrome|Neuro-Degenerative Disease|Normal Cognition
Interventions: DEVICE: Retinal and Choroidal Imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparison of Sartorius Vs. Quadriceps Evoked Motor Response for Femoral Nerve to Prevent Secondary Catheter Failure
Status: UNKNOWN
Conditions: Arthroplasty, Replacement, Knee
Interventions: OTHER: Stimulation of quariceps muscle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study to Investigate the Pharmacokinetic Profiles and Safety of High-dose CKD-385 in Healthy Volunteers(Fed)
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DRUG: Reference drug|DRUG: Test drug 1|DRUG: Test drug 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma|Open-Angle Ocular Hypertension
Interventions: DRUG: Bimatoprost SR|DRUG: Sham Bimatoprost SR|PROCEDURE: Selective Laser Trabeculoplasty|PROCEDURE: Sham Selective Laser Trabeculoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploring the Impact of a Multi-modal Nutritional Intervention in Patients Undergoing Chemotherapy for Pancreatic Cancer (FEED Trial)
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DIETARY_SUPPLEMENT: Control|DIETARY_SUPPLEMENT: Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Lavender Inhalation on Sleep Quality in Individuals With Coronary Heart Disease
Status: COMPLETED
Conditions: Nursing Caries
Interventions: OTHER: THE EFFECT OF LAVENDER INHALATION ON SLEEP QUALITY IN INDIVIDUALS WITH CORONARY HEART DISEASE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety Analysis of ICIs Plus Angiogenesis Inhibitors for Treatment of Advanced NSCLC in Elderly Patients
Status: COMPLETED
Conditions: NSCLC
Interventions: DRUG: Immune checkpoint inhibitors plus angiogenesis inhibitors|DRUG: Immune checkpoint inhibitors without angiogenesis inhibitors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PAIN - Postoperative Analgesia INvestigation
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Exparel|DRUG: Bupivacaine hydrochloride|DRUG: Patient Controlled Analgesia (PCA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 99mTc-ADAPT6 SPECT-based Non-invasive Quantification of HER2-expression in Breast Cancer With Metastatic Lymph Nodes
Status: COMPLETED
Conditions: Breast Cancer|Female
Interventions: DRUG: ADAPT6-SPECT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Immunogenicity and Preliminary Clinical Activity Study of PDC*lung01 Cancer Vaccine in NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: PDC*lung01|DRUG: Keytruda Injectable Product|DRUG: Alimta Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: General Anesthesia With or Without Local Ear Block in Middle Ear Surgeries
Status: COMPLETED
Conditions: Tympanum; Perforation
Interventions: DRUG: local anaesthetic injection|DRUG: Normal Saline Flush, 0.9% Injectable Solution|DRUG: general anesthetic|DRUG: Hypotensives
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: HEalth Care Worker pROphylaxis Against COVID-19: The HERO Trial
Status: UNKNOWN
Conditions: Prophylaxis|COVID-19|Health Care Worker|Hydroxychloroquine
Interventions: DRUG: Hydroxychloroquine Pre-Exposure Prophylaxis|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Preventive Interventions for Chronic Pain Worsening
Status: NOT_YET_RECRUITING
Conditions: Chronic Non-Cancer Pain
Interventions: BEHAVIORAL: Online Mindfullness Based Stress Reduction Program|DEVICE: Virtual Reality-based Pain Self-management program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Reversing Muscle Loss With Exercise Training and Daily Consumption of Pomegranate Juice
Status: COMPLETED
Conditions: Sarcopenia|Cardiovascular Risk Factor
Interventions: OTHER: Inertial Load Cycling Training|DIETARY_SUPPLEMENT: Pomegranate Juice|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Intra-operative Ultrasound Guided Laparoscopic Ovarian Cystectomy as a Method of Fertility Preservation
Status: RECRUITING
Conditions: Benign Ovarian Cyst
Interventions: PROCEDURE: Ultrasound guided laparoscopic ovarian cystectomy|OTHER: Laparoscopic Ovarian Cystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrin β7, BCMA, CS1, CD38 and CD138 as the Single or Compound Targets for the Fourth Genenation of CAR-T Cells
Status: UNKNOWN
Conditions: RRMM
Interventions: BIOLOGICAL: CAR-T therapy in Relapsed/Refractory multiple myeloma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Progesterone Treatment of Blunt Traumatic Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: DRUG: IV Progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus in Pregnant Women and in Infants Born to Vaccinated Mothers
Status: RECRUITING
Conditions: Respiratory Syncytial Virus
Interventions: BIOLOGICAL: mRNA-1345|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Registry to Collect Data on Patients Undergoing Segmental Mandibular Defect Reconstruction Following Oral Squamous Cell Carcinoma Resection
Status: RECRUITING
Conditions: Mandibular Reconstruction|Segmental Mandibular Defects
Interventions: PROCEDURE: Surgical Resection and Reconstruction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Can (Optical Coherence Tomography) Pictures of the Retina Detect Alzheimer's Disease at Its Earliest Stages?
Status: ENROLLING_BY_INVITATION
Conditions: Alzheimer Disease|Mild Cognitive Impairment
Interventions: DIAGNOSTIC_TEST: Optical Coherence Tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety and Efficacy of MabThera (Rituximab) in Combination With Methotrexate (MTX) in Participants With Active Rheumatoid Arthritis Who Failed on Anti-Tumor Necrosis Factor Alpha Therapy
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: MabThera/Rituxan|DRUG: Methotrexate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: DIVIT Study Diet and Vitamin Supplementation in Patients With a Neuroendocrine Tumor
Status: COMPLETED
Conditions: Neuroendocrine Tumor
Interventions: DIETARY_SUPPLEMENT: Vitamin supplement;|OTHER: Diet advice
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug-Eluting Balloon in Stable and Unstable Angina
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: drug-eluting balloon (DEB)|PROCEDURE: bare-metal stent (BMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Onset and Duration of Action of RX-10045 in Allergic Conjunctivitis
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: RX-10045|DRUG: Vehicle for RX-10045 arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ACCU-CHEK® Aviva Expert Study: Does Use of a Bolus Advisor Improve Glycemic Control in Patients Not Achieving Optimal Control Using Multiple Daily Injections (MDI)?
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DEVICE: Aviva Expert blood glucose meter|DEVICE: Aviva Nano blood glucose meter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical vAlidation of a MobilE appLication ("ProRodinki") in the Assessment of the maLignant skIn neoplAsms
Status: UNKNOWN
Conditions: Melanoma (Skin)|Nevus|Nevus, Spitz|Nevus Halo|Nevus, Pigmented|Basal Cell Carcinoma|Squamous Cell Carcinoma|Bowen's Disease|Melanoma in Situ|Spot Pigmented
Interventions: OTHER: Mobile phone application "ProRodinki"
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Analgesic Effects of Transversus Thoracic Plane (TTP) Block in Cardiac Surgery
Status: UNKNOWN
Conditions: Postoperative Pain|Nerve Block|Cardiac Surgery
Interventions: PROCEDURE: Transthoracic Transversus Plane Block|DRUG: Hydromorphone Hydrochloride|DRUG: Aspirin|DRUG: Acetaminophen|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Next Generation T-cell Vaccine Against Coronavirus Disease (COVID-19)
Status: NOT_YET_RECRUITING
Conditions: Coronavirus|SARS-CoV-2 Infection|COVID-19
Interventions: BIOLOGICAL: PepGNP-COVID19 (One vaccination)|OTHER: Water for injection (One vaccination)|BIOLOGICAL: PepGNP-COVID19 (Two vaccinations)|OTHER: Water for injection (Two vaccinations)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Levamlodipine Besylate Compared to Amlodipine Maleate in Patients With Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Levamlodipine besylate|DRUG: Amlodipine maleate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of FLUTTER® VRP1 (PEP and Oscillating High Frequency).
Status: TERMINATED
Conditions: Bronchiectasis
Interventions: OTHER: control group|OTHER: Flutter group|OTHER: PEP group|OTHER: Group Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Dose Escalation Study of the Tumor-targeting Human L19-IL2 Monoclonal Antibody-cytokine Fusion Protein in Combination With Dacarbazine for Patients With Metastatic Melanoma
Status: UNKNOWN
Conditions: Metastatic Melanoma Stage IV
Interventions: DRUG: L19IL2 - Ph I|DRUG: L19IL2 at RD - Ph II|DRUG: DTIC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine and Erlotinib Before and After Surgery in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: erlotinib hydrochloride|DRUG: gemcitabine hydrochloride|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Music Breathing Therapy for Children With Attention-deficit Hyperactivity Disorder and Their Caregivers
Status: RECRUITING
Conditions: Resilience
Interventions: BEHAVIORAL: Dyadic video-assisted gamified group-based music breathing therapy|BEHAVIORAL: Online educational modules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety of an Inactivated Enterovirus Type 71 Vaccines in Healthy Children
Status: COMPLETED
Conditions: Hand-foot-mouth Disease|Infection; Viral, Enterovirus
Interventions: BIOLOGICAL: 100U inactivated Enterovirus Type 71 Vaccine|BIOLOGICAL: 200U inactivated Enterovirus Type 71 Vaccine|BIOLOGICAL: 400U inactivated Enterovirus Type 71 Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Afamelanotide as Adjunctive Therapy in Patients Undergoing Photodynamic Therapy (PDT) Utilising Porfimer Sodium
Status: COMPLETED
Conditions: Patients Undergoing Photodynamic Therapy Using Porfimer Sodium
Interventions: DRUG: Afamelanotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liraglutide Efficacy on Glucocorticoid Induced Hyperglycemia in Patients High Risk for Diabetes
Status: UNKNOWN
Conditions: Glucocorticoid Induced Hyperglycemia
Interventions: DRUG: Liraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Recompensation of Exacerbated Liver Insufficiency With Hyperbilirubinemia and/or Encephalopathy and/or Renal Failure
Status: COMPLETED
Conditions: Liver Failure
Interventions: DEVICE: MARS device|PROCEDURE: Standard medical therapy|PROCEDURE: Standard medical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Study With Combination Immuno-oncology for Primary Clear Cell Renal Cell Cancer
Status: RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Neoadjuvant nivolumab|DRUG: Neoadjuvant ipilimumab|DRUG: Neoadjuvant relatlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Percutaneous Repair of Functional Mitral Regurgitation Using the Ancora Heart, Inc. AccuCinch® Ventricular Repair System - The CINCH-2 Study
Status: COMPLETED
Conditions: Mitral Regurgitation|Mitral Valve Regurgitation|Functional Mitral Regurgitation
Interventions: DEVICE: AccuCinch® Ventriculoplasty System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Measuring Effects of Prebiotics on Human Behavior and Cognition
Status: COMPLETED
Conditions: Prebiotics and Human Behavior and Cognition
Interventions: DIETARY_SUPPLEMENT: Inulin|DIETARY_SUPPLEMENT: Placebo (maltodextrin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: EBV-Specific CTLs Following CD45 Antibody to Patients With Epstein-Barr Virus (EBV) + Nasopharyngeal Carcinoma (NPC)
Status: COMPLETED
Conditions: Nasopharyngeal Cancer|EBV Infections
Interventions: BIOLOGICAL: EBV specific CTL Infusion|BIOLOGICAL: Anti CD45 monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Hypnoanalgesia by a Radiologist Technologist in Children With Cutaneous Angioma Treated With Sclerosis in Interventional Radiology
Status: NOT_YET_RECRUITING
Conditions: Angioma
Interventions: OTHER: Hypnoanalgesia group|OTHER: Meopa Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE
Status: RECRUITING
Conditions: Ischemic Stroke, Acute
Interventions: DRUG: Riociguat|DRUG: Propylthiouracil|DRUG: Perphenazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HYHOPE: De-intensified Hypofractionated Radiation Therapy for HPV-associated Oropharynx Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Human Papillomavirus-Related Carcinoma|Oropharyngeal Cancer
Interventions: RADIATION: Hypofractionated intensity modulated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Bevacizumab Plus Docetaxel in High Risk Patients With Prostate Cancer Undergoing Radical Prostatectomy
Status: COMPLETED
Conditions: Prostate Cancer|Adenocarcinoma of the Prostate
Interventions: DRUG: Bevacizumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: T-Cell Depleted Allogeneic Stem Cell Transplantation for Patients With Hematologic Malignancies
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Lymphoid Leukemia|Chronic Myelogenous Leukemia|Malignant Lymphoma|Hodgkin's Disease|Chronic Lymphocytic Leukemia|Myeloproliferative Disorder|Anemia, Aplastic|Myelodysplastic Syndromes
Interventions: DRUG: Fludarabine|DRUG: Melphalan|DRUG: Stem cells|DRUG: Campath
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Efficacy on the 5th Day of Antibiotic Therapy for Febrile Urinary Tract Infections Among Children From 3 Months to 18 Years Old
Status: UNKNOWN
Conditions: Urinary Tract Infections|Pediatric Disorder
Interventions: OTHER: Survey
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetic / Pharmacodynamic Study Comparing MYL-1401H, EU-sourced Neulasta and US-licensed Neulasta
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: MYL-1401H|BIOLOGICAL: EU-Neulasta|BIOLOGICAL: US-Neulasta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Maintenance Niraparib and Dostarlimab in Advanced Cholangiocarcinoma
Status: WITHDRAWN
Conditions: HRD|Cholangiocarcinoma|Metastatic Cancer
Interventions: DRUG: Niraparib|DRUG: Dostarlimab|DRUG: Dostarlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Changes of Inflammatory Proteins in Aqueous Humour of Subjects Treated With Avastin vs Lucentis
Status: COMPLETED
Conditions: Proliferative Diabetic Retinopathy (PDR)
Interventions: OTHER: Injection of Avastin / Lucentis, sampling aqueous humour
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of Different Long-acting Bronchodilator Medications on Asthma Patients With Different Genetic Variations
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: tiotropium bromide|DRUG: Salmeterol|DRUG: Formoterol|DRUG: Fluticasone propionate|DRUG: budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 68 Ga-NODAGA-E[c(RGDγK)]2: Positron Emission Tomography Tracer for Imaging of Angiogenesis in Ischemic Heart Disease
Status: NOT_YET_RECRUITING
Conditions: Chronic Ischemic Heart Disease
Interventions: DRUG: 68Ga-NODAGA-E[c(RGDyK)]2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Topical Nitro or Placebo Pre-Cath
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DRUG: NitroBid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose of Dexamethasone in Femur Fractures
Status: UNKNOWN
Conditions: Fractured Neck of Femur
Interventions: DRUG: Dexamethasone acetate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Study of Conversion Surgery for Apatinib in Combination With SOX for Patients With Unresectable Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: Apatinib|DRUG: Oxaliplatin|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Letrozole in the Treatment of 1st and 2nd Line Hormone Receptor Positive Breast Cancer: Pre-therapeutic Risk Assessment
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Measurement of VItal SIgns by Lifelight® Software in comparisON to the Standard of Care - Multi-site Development
Status: COMPLETED
Conditions: Respiratory Disorder|Diabetes|Cardiovascular Diseases|Critical Care|Trauma and Emergency Care|Primary Care
Interventions: DEVICE: Lifelight Data Collect Sub-protocol 1|DEVICE: Lifelight Data Collect Sub-protocol 2|DEVICE: Lifelight Data Collect Sub-protocol 3|DEVICE: Lifelight Data Collect Sub-protocol 4
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pivotal Study of the CapsoCam Colon (CV-3) in Detecting Colonic Polyps, Using Colonoscopy as the Reference
Status: RECRUITING
Conditions: Colonic Polyp
Interventions: DEVICE: Capsule Endoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Placebo-controlled Study of Efficacy & Safety of 2 Trough-ranges of Everolimus as Adjunctive Therapy in Patients With Tuberous Sclerosis Complex (TSC) & Refractory Partial-onset Seizures
Status: COMPLETED
Conditions: Tuberous Sclerosis Complex-associated Refractory Seizures
Interventions: DRUG: RAD001|DRUG: Placebo|DRUG: Antiepileptic drug (1 to 3 only)|DRUG: open label RAD001 (only used for post-extension phase)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes
Status: RECRUITING
Conditions: Gestational Diabetes Mellitus|Pregnancy, High Risk
Interventions: DRUG: Metformin|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First Line Treatment in EGFR Mutation Positive Advanced NSCLC Patients With Central Nervous System (CNS) Metastases
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer|EGFR Gene Mutation|Brain Metastases
Interventions: DRUG: AZD3759|DRUG: Erlotinib|DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Virtual Reality Application Used During Endoscopy on Pain, Anxiety and Vital Signs: A Mixed Methods Study
Status: ENROLLING_BY_INVITATION
Conditions: Patient Relations, Nurse|Nurse's Role|Supportive Care
Interventions: OTHER: Experimental group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase-I Study to Evaluate the Safety and Immunogenicity of a Prophylactic pDNA Vaccine Candidate Against COVID-19 in Healthy Adults
Status: NOT_YET_RECRUITING
Conditions: Safety|Vaccine Reaction|Vaccine Adverse Reaction|Immunization; Infection
Interventions: DRUG: S.opt.FL COVID-19 pDNA vaccine|DRUG: S.opt.FL COVID-19 pDNA vaccine|DRUG: S.opt.FL COVID-19 pDNA vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trials for the Effects of Polygoni Multiflori Radix Complex Extract on Memory Improvement
Status: UNKNOWN
Conditions: Memory, Short-Term
Interventions: DIETARY_SUPPLEMENT: Polygoni Multiflori Radix complex extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Passive Leg Raising Test to Predict Hypotension During Induction of Anesthesia in Patients Undergoing Cardiac Surgery
Status: COMPLETED
Conditions: Ischemic Heart Disease|Cardiac Valve Disease
Interventions: PROCEDURE: passive leg raising (45 degree leg elevation for 1-2 min)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Quantification of Silicone Oil Emulsification After Pars Plana Vitrectomy
Status: UNKNOWN
Conditions: PArs Plana Vitrectomy|Retinal Detachment|Silicone Oil Droplets on Intraocular Lens
Interventions: PROCEDURE: pars plana vitrectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Anti-PD-L1 Antibody ZKAB001 Combined With Albumin-bound Paclitaxel in Advanced Urothelial Carcinoma
Status: UNKNOWN
Conditions: Advanced Urothelial Carcinoma
Interventions: DRUG: anti-PD-L1 antibody|DRUG: albumin bound paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Clinical Study of Different Intraocular Lens Implantation Designed for the Correction of Presbyopia
Status: UNKNOWN
Conditions: Presbyopia|Cataract Senile
Interventions: DEVICE: bifocal IOL|DEVICE: mix bifocal IOL|DEVICE: trifocal IOL|DEVICE: EDOF IOL|DEVICE: different IOLs|DEVICE: monofocal IOL|DEVICE: monofocal IOL
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intratumoral Vaccination With Intuvax Pre-nephrectomy Followed by Sunitinib Post-nephrectomy vs Sunitinib Post-nephrectomy in Newly Diagnosed Metastatic Renal Cell Carcinoma (mRCC)
Status: COMPLETED
Conditions: Renal Cell Carcinoma, Metastatic
Interventions: BIOLOGICAL: Intuvax (INN: ilixadencel)|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of First-void Urine as an Alternative to Cervical Sampling for Human Papillomavirus (HPV) Testing in Cervical Cancer Screening (Single-center Study).
Status: RECRUITING
Conditions: Uterine Cervical Cancer
Interventions: OTHER: Urine sample, 1st stream|OTHER: Cervico-vaginal swab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Technique on the Local Anesthetic Dose Required for Interscalene Brachial Plexus Block
Status: UNKNOWN
Conditions: Arthroscopic Shoulder Surgery
Interventions: OTHER: Ultrasound Minimum Effective Anesthetic Volume|OTHER: Nerve Stimulator Minimum Effective Anesthetic Volume
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Calcium and Vitamin D Supplementation Decreases Incidence of Stress Fractures in Female Navy Recruits
Status: COMPLETED
Conditions: Stress Fracture
Interventions: DIETARY_SUPPLEMENT: Calcium & Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Smoking Cessation on Tuberculosis Treatment Outcomes
Status: COMPLETED
Conditions: Tuberculosis, Pulmonary
Interventions: DRUG: Bupropion|BEHAVIORAL: Behavioural Change Communication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Digital Cognitive Behavioral Therapy (dCBT-I) for Maternal Insomnia
Status: UNKNOWN
Conditions: Digital Cognitive Behavioral Therapy for Insomnia (dCBT-I)
Interventions: OTHER: dCBT-I
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Oleactiv® on LDL Oxidability
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: Plant food supplement|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Compare the Accuracy of ctDNA-MRD and MVI Result in Predicting Postoperative Recurrence of Hepatocellular Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma Resectable|Surgery|Recurrence
Interventions: DIAGNOSTIC_TEST: circulating tumor cell DNA detection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TAS-117 in Patients With Advanced Solid Tumors Harboring Germline PTEN Mutations
Status: TERMINATED
Conditions: Advanced or Metastatic Solid Tumors Irrespective of Gene Alterations|Advanced or Metastatic Solid Tumors With Germline PTEN Inactivating Mutations
Interventions: DRUG: TAS-117|DRUG: TAS-117|DRUG: TAS-117|DRUG: TAS-117
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Commonly Available Food Products To Treat Food Allergy
Status: RECRUITING
Conditions: IgE-Mediated Cow Milk Allergy|Peanut Allergy
Interventions: OTHER: Peanut in common foods or supermarket-sourced cow's milk (CM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Superficial, Cervical Block in Thyroid Surgery, a Randomized Controlled Trial
Status: COMPLETED
Conditions: Thyroidectomy
Interventions: DRUG: bilateral superficial cervical block|DRUG: placebo bilateral superficial cervical block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neurodynamic of the Human Brain Underlying Animal-assisted Intervention in Healthy Adults
Status: COMPLETED
Conditions: Animal-assisted Intervention
Interventions: OTHER: Animal-assisted intervention|OTHER: Factice dog intervention|OTHER: Plant intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Radiofrequency-assisted Transection of the Pancreas vs Stapler
Status: RECRUITING
Conditions: Pancreas; Fistula
Interventions: PROCEDURE: Radiofrequency-assisted pancreas transection|PROCEDURE: Stapler assisted pancreas transection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CDP-Choline and Working Memory After TBI: A Neuroimaging Study
Status: COMPLETED
Conditions: Brain Injuries
Interventions: DRUG: CDP-Choline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optokinetic Stimulation for Hemineglect
Status: RECRUITING
Conditions: Perceptual Disorders|Unilateral Spatial Neglect
Interventions: OTHER: Optokinetic stimulation|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Phenylephrine Solution in Preventing Oral Mucosa in Bone Marrow Transplant Patients Receiving Cyclophosphamide and Total Body Radiation Therapy
Status: TERMINATED
Conditions: Neoplasm|Oral Mucosa|Transplant-Related Disorder
Interventions: DRUG: Topical Phenylephrine Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Evolocumab on Coronary Atherosclerosis
Status: COMPLETED
Conditions: Cardiovascular Disease|Hyperlipidemia
Interventions: DRUG: Evolocumab|DIAGNOSTIC_TEST: 18F-NaF PET|DIAGNOSTIC_TEST: CCTA|DRUG: Omnipaque|DRUG: Metoprolol|DRUG: Nitroglycerin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Saline-Enhanced Radiofrequency (SERF) Catheter Ablation for the Treatment of Ventricular Tachycardia
Status: COMPLETED
Conditions: Tachycardia, Ventricular
Interventions: DEVICE: Saline-Enhanced Radiofrequency Catheter and Ablation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effectiveness of e-CBTi Compared to Pharmaceutical Interventions in Treating Insomnia
Status: RECRUITING
Conditions: Insomnia
Interventions: BEHAVIORAL: e-CBTi|DRUG: Trazodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Degree of Hypofunction and Vestibular Tests in Patients With Vestibular Hypofunction
Status: RECRUITING
Conditions: Videonystagmography|Vestibular Assessment
Interventions: DIAGNOSTIC_TEST: Vestibular Hypofunction Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Radiation Therapy (Hypofractionated Proton Beam Therapy or IMRT) for the Treatment of Recurrent, Oligometastatic Prostate Cancer Following Primary Localized Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Prostate Adenocarcinoma|Oligometastatic Prostate Carcinoma|Prostate Adenocarcinoma|Recurrent Prostate Carcinoma|Stage IV Prostate Cancer AJCC v8
Interventions: RADIATION: Intensity-Modulated Radiation Therapy|RADIATION: Proton Beam Radiation Therapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of RO5217790 in Participants With High Grade Cervical Intraepithelial Neoplasia (CIN) Associated With High Risk Human Papillomavirus (HR-HPV) Infection
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia
Interventions: DRUG: Placebo|DRUG: RO5217790
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of SYN006, Pulmicort pMDI and Meptin Air in Healthy Adult.
Status: COMPLETED
Conditions: Asthma|Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Budesonide|DRUG: Procaterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Value of FEC-PET Combined With Endorectal MRI for Pre-therapeutic Staging of Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: OTHER: 18F-Ethylcholine Positron Emission Tomography (FEC-PET)|OTHER: Endorectal Magnetic Resonance Imaging (1.5Tesla) (eMRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Benefit Study of Droxidopa to Treat Patients With Intradialytic Hypotension
Status: COMPLETED
Conditions: Intradialytic Hypotension
Interventions: DRUG: Droxidopa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Overcoming Primary Resistance to Immunotherapy in Metastatic Melanoma
Status: NOT_YET_RECRUITING
Conditions: Malignant Melanoma|Metastatic Melanoma|Immunotherapy|BRAF V600E|Malignant Melanoma Stage IV
Interventions: DRUG: Pembrolizumab|DRUG: Encorafenib|DRUG: Binimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observation or Upfront Cranial RT in Oncogene Mutated NSCLC With Asymptomatic BM: A Phase III RCT
Status: RECRUITING
Conditions: Asymptomatic Brain Metastases|Driver Mutation Positive Non-small Cell Lung Cancer
Interventions: RADIATION: Stereotactic radiosurgery/whole brain radiotherapy|DRUG: Tyrosine kinase inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardioprotective Effects of Cardiopeptides for Injection in Patients With Non-severe Cardiac Disease: a Single-center Randomized Controlled Trial
Status: RECRUITING
Conditions: Myocardial Injury|ICU
Interventions: DRUG: Cardiopeptides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Efficacy and Safety of Pulp Regeneration Induced by SHED Polymerization
Status: NOT_YET_RECRUITING
Conditions: Pulp Necroses
Interventions: DRUG: Allogeneic human pulp mesenchymal stem cells mixed with hyaluronic acid polymers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Metastatic Castrate Resistant Prostate Cancer Patients According to Circulating Tumor Cells Kinetic
Status: COMPLETED
Conditions: Prostate Carcinoma|Castration-resistant Prostate Cancer|Circulating Tumor Cells|Chemotherapy
Interventions: DRUG: Cabazitaxel|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of QLF31907 in Advanced Melanoma and Urothelial Carcinoma
Status: RECRUITING
Conditions: Melanoma|Urothelial Carcinoma
Interventions: DRUG: QLF31907
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuroprotection by Cannabinoids in Huntington's Disease
Status: COMPLETED
Conditions: Huntington's Disease
Interventions: DRUG: delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Privigen in Subjects With Chronic Inflammatory Demyelinating Polyneuropathy
Status: COMPLETED
Conditions: Chronic Inflammatory Demyelinating Polyneuropathy
Interventions: BIOLOGICAL: 10% liquid formulation of human immunoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT