pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Atazanavir/Ritonavir, Once Daily + Raltegravir, Twice Daily, Switch Study in HIV-1-Infected Patients
Status: COMPLETED
Conditions: HIV, Combination Therapy
Interventions: DRUG: Atazanavir|DRUG: Ritonavir (heat-stable)|DRUG: Raltegravir|DRUG: Tenofovir/Emtricitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strategy of Crossing Two Ablation Techniques (Cryoballoon and Radiofrequency) After the Recurrence of Paroxysmal AF and the Need for a New Procedure
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ia/Ib Study of IBI315 in Patients With HER2-expressing Advanced Solid Tumor
Status: COMPLETED
Conditions: Advanced Solid Tumor
Interventions: DRUG: IBI315|DRUG: IBI315
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benefit/Risk in Real Life of New Oral Anticoagulants and Vitamin K Antagonists in Patients Aged 75 Years and Over Suffering From Non Valvular Atrial Fibrillation (nv AF)
Status: UNKNOWN
Conditions: Non Valvular Atrial Fibrillation (nv AF)
Interventions: DRUG: Non-exposed group|DRUG: Exposed group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial to Compare Efficacy and Safety of Chemotherapy/Quizartinib vs Chemotherapy/Placebo in Adults FMS-like Tyrosine Kinase 3 (FLT3) Wild-type Acute Myeloid Leukemia (AML)
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Quizartinib|DRUG: Placebo oral tablet|DRUG: Cytarabine|DRUG: Idarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Aplindore in Patients With Restless Legs Syndrome
Status: TERMINATED
Conditions: Restless Legs Syndrome
Interventions: DRUG: aplindore MR tablets or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TIPS Versus Portacaval Shunt for Acute Bleeding Varices in Cirrhosis
Status: COMPLETED
Conditions: Bleeding
Interventions: PROCEDURE: Emergency portacaval shunt|OTHER: Emergency TIPS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Two Doses of Oral Melatonin as Premedication in Children Undergoing Surgery
Status: RECRUITING
Conditions: Preoperative Anxiety
Interventions: DRUG: melatonin (Circadin ®) 0.2 mg/kg|DRUG: melatonin (Circadin ®) 0.4 mg/kg|DRUG: placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: PRostate Evaluation for Clinically Important Disease: Sampling Using Image-guidance Or Not?
Status: COMPLETED
Conditions: Prostate Neoplasm
Interventions: DEVICE: MRI|PROCEDURE: MRI-targeted biopsy|PROCEDURE: TRUS-biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Treatment of Opioid/Heroin Dependence: Comparison of Three Medication Dosing Regimens
Status: COMPLETED
Conditions: Heroin Dependence|Opioid-Related Disorders
Interventions: DRUG: Levoacetyl Methadol|DRUG: Levoacetyl Methadol|DRUG: Levoacetyl Methadol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of a Manufacturing Process for a Frequent Replacement Silicone Hydrogel Multifocal Contact Lens
Status: COMPLETED
Conditions: Refractive Ametropia
Interventions: DEVICE: Lehfilcon A multifocal contact lenses|DEVICE: Lotrafilcon B multifocal contact lenses|DEVICE: Hydrogen peroxide-based cleaning and disinfection system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Drug Reactions Sampling (COLLECTIONTOXIDERMIES)
Status: RECRUITING
Conditions: Stevens-Johnson Syndrome|Lyell Syndrome|Drug Reactions|AGEP|DRESS|Bullous Dermatosis Caused by Drug Treatment (Disorder)|Maculopapular Exanthem|Erythema Multiforme
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy Of Pulsed Electromagnetic Field Therapy On Neurogenic Bladder in Children With Myelomeningocele
Status: COMPLETED
Conditions: Neurogenic Bladder
Interventions: DEVICE: pulsed electromagnetic field therapy device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Oat Beta Glucan in Managing Blood Pressure
Status: COMPLETED
Conditions: Elevated Blood Pressure
Interventions: OTHER: High molecular weight β-glucan oat cookies|OTHER: Control wheat based cookies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vasopressin Effects on Human Social Communication
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Vasopressin, Arginine, ADH|DRUG: Placebo; Sterile Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Birth Defects Associated With Exposure to Lamotrigine in Pregnancy (EUROCAT)
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Lamotrigine monotherapy|DRUG: No anti-epileptic drug exposure|DRUG: Non lamotrigine anti-epileptic drug monotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: N-Acetylcysteine for Neuroprotection in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: N-acetylcysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Avastin (Bevacizumab) in Combination With Taxane-based Chemotherapy as First Line Treatment in Patients With HER-2 Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Bevacizumab|DRUG: Paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Specific Immunotherapy With an Aluminium Hydroxide-adsorbed Allergoid Preparation of Birch Pollen Allergens
Status: COMPLETED
Conditions: Pollen Allergy
Interventions: BIOLOGICAL: Birch pollen allergoid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study For Patients Receiving Radiation Therapy for Liver Cancer
Status: NOT_YET_RECRUITING
Conditions: Cancer, Hepatocellular|Radiotherapy Side Effect
Interventions: DEVICE: Multiparametric MRI scans|DEVICE: Multiparametric MRI scans + HepQuantShunt Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Condrosulf vs Celebrex vs Placebo in the Treatment of Knee OA
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: chondroitin sulfate|DRUG: celecoxib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Aromatherapy on Patients Undergoing Chemotherapy for Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Sleep Quality|Anxiety
Interventions: OTHER: Aromatherapy|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Ranibizumab (Lucentis®) in the Treatment of Non-leaking Macular Cysts in Retinal Dystrophy
Status: COMPLETED
Conditions: Retinal Dystrophies
Interventions: DRUG: Intravitreal ranibizumab (IVR) injection|DRUG: Carbonic Anhydrase Inhibitor (CAI) therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Cholesterol Lowering Drugs Influence Circulating Omega-3 Fatty Acid Levels
Status: COMPLETED
Conditions: Hypercholesterolemia|Hyperlipidemia
Interventions: DIETARY_SUPPLEMENT: Flax seed oil (ALA)|DRUG: Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Pilot Study 1: Efficacy and Safety of Sublingual Dexmedetomidine (BXCL501) for the Treatment of Agitation in the Emergency Department
Status: NOT_YET_RECRUITING
Conditions: Agitation|Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorders|Bipolar Disorder
Interventions: DRUG: Sublingual film containing dexmedetomidine (BXCL501)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial, Open, Multicenter Parallel, no Suspension Inferiority Prophylactic Treatment With Valganciclovir in Kidney Transplant CMV-seropositive Cellular Immunity to Develop CD8 + CMV-specific Treatment After Induction Thymoglobulin.
Status: COMPLETED
Conditions: Kidney Transplant Infection
Interventions: DRUG: New profilaxis|DRUG: Profilaxis recommended
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluid Responsiveness in Septic Shock Evaluated by Caval Ultrasound Doppler Examination
Status: UNKNOWN
Conditions: Septic Shock|Vein Collapsibility|Intravascular Doppler|Volume Responsiveness in Septic Shock
Interventions: PROCEDURE: passive leg raising
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Acute Exercise on Various Parameters in Individuals With Alcohol Use Disorders
Status: COMPLETED
Conditions: Heavy Drinking|Alcohol Abuse|Alcohol Dependence|Alcohol Use Disorder
Interventions: BEHAVIORAL: The effects of acute exercise in heavy drinkers|BEHAVIORAL: The effects of acute exercise in alcoholic patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Siltuximab (CNTO 328) in Male Subjects With Metastatic Hormone-Refractory Prostate Cancer (HRPC)
Status: TERMINATED
Conditions: Cancer, Prostate
Interventions: DRUG: Mitoxantrone|DRUG: Siltuximab|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Consumption of a Spinach Extract on Muscle Function in Subjects Over 50 Years of Age
Status: COMPLETED
Conditions: Sarcopenia|Physical Exercise
Interventions: DIETARY_SUPPLEMENT: Dietary supplement consumption and physical exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FOODS: Food shOppers' sOcial meDia Study
Status: COMPLETED
Conditions: Eating Behaviour of Discretionary Foods|Cognitive Restraint of Eating|Physical Activity|Body Weight
Interventions: BEHAVIORAL: PACE plus calorie labelling information|BEHAVIORAL: Calorie-only labelling information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Corticoid Infiltration in Quadratus Lumborum Syndrome
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: DRUG: Quadratus triamcinolone|DRUG: Gluteus triamcinolone|DRUG: quadratus without triamcinolone.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Safety, Pharmacokinetics, and Pharmacodynamics of Single Ascending Intravenous Doses of UCB0107 in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Male Volunteers
Interventions: DRUG: UCB0107|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: MethOxyflUraNe at moderaTe High AltItudes for PAIN Management
Status: UNKNOWN
Conditions: Pain
Interventions: DRUG: Methoxyflurane|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radicle Energy2: A Study of Health and Wellness Products on Fatigue and Other Health Outcomes
Status: COMPLETED
Conditions: Fatigue|Energy
Interventions: DIETARY_SUPPLEMENT: Energy Placebo Control Form 1|DIETARY_SUPPLEMENT: Energy Active Study Product 1.1 Usage|DIETARY_SUPPLEMENT: Energy Active Study Product 1.2 Usage|DIETARY_SUPPLEMENT: Energy Active Study Product 1.3 Usage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of PMZ-2010 (Centhaquine) a Resuscitative Agent for Hypovolemic Shock
Status: COMPLETED
Conditions: Hypovolemic Shock
Interventions: DRUG: Normal saline + Standard Treatment|DRUG: Centhaquine + Standard Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Hepatic Rigidity by Ultrasonic Impulse Elastography in Liver Transplant Patients
Status: COMPLETED
Conditions: Hepatic Transplantation
Interventions: DIAGNOSTIC_TEST: Hepatic Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Aspirin in Treating Patients With Colorectal Cancer That Has Been Surgically Removed
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: aspirin|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Internet Based Exercise Training in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: OTHER: Internet based exercise training|OTHER: group exercise training|OTHER: Physical activity counselling via a brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Sacituzumab Govitecan in Participants With Metastatic Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Solid Tumor
Interventions: DRUG: Sacituzumab Govitecan-hziy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Reduction Using Two Cold Irrigating Protocols in Teeth With Vital Pulps.
Status: COMPLETED
Conditions: Post Operative Pain
Interventions: PROCEDURE: For the Group A. Applied Cryotherapy at 6 oC|PROCEDURE: For the Group B. Applied Cryotherapy at 2.5 oC|PROCEDURE: Control Group (CG). Applied irrigant at room temperature
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sunitinib and Radiation in Patients With Resectable Soft-tissue Sarcoma
Status: UNKNOWN
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: Sunitinib malate|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hormonal Influences on Inflammatory Bowel Diseases
Status: NOT_YET_RECRUITING
Conditions: Inflammatory Bowel Diseases|Contraception|Menstrual Problem
Interventions: OTHER: Proposed study design and randomization scenarios|OTHER: Repeated measures of validated Inflammatory Bowel Disease Patient Reported Outcome Instruments|OTHER: Inflammatory marker collection and assessment for correlation with PRO responses and menstrual timing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Tongguan Capsule for MicroRNA Profiles in Coronary Heart Disease Patients
Status: UNKNOWN
Conditions: Coronary Heart Disease|Acute Myocardial Infarction
Interventions: DRUG: Tongguan capsule|DRUG: placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Goldmann Applanation Tonometry, Dynamic Contour Tonometry, and Corvis ST Tonometer
Status: COMPLETED
Conditions: Glaucoma
Interventions: DEVICE: Measurement of intraocular pressure (IOP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Lapaquistat Acetate Combined With Fenofibrate on Blood Cholesterol Levels
Status: COMPLETED
Conditions: Hyperlipidemias
Interventions: DRUG: Lapaquistat acetate and fenofibrate|DRUG: Fenofibrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of E7777 in Persistent and Recurrent Cutaneous T-Cell Lymphoma
Status: COMPLETED
Conditions: Persistent or Recurrent Cutaneous T-Cell Lymphoma
Interventions: DRUG: E7777 9 mcg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Xalacom® (Latanoprost/Timolol) and Combigan® (Brimonidine/Timolol) Fixed Combination on Intraocular Pressure and Ocular Blood Flow in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Retina|Ocular Physiology
Interventions: DRUG: latanoprost 0.005% + timolol 0,5% fixed combination|DRUG: brimonidine 0,2% + timolol 0,5% fixed combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Computer Program in Improving Communication Between Doctors and Patients With Stage IV Cancer
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BEHAVIORAL: communication lecture|BEHAVIORAL: lecture plus CD-ROM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparing Pain and Swelling After Surgical Extraction of Mandibular Third Molar in Dexamethasone Injection and Without Corticosteroid Methods
Status: UNKNOWN
Conditions: Oral Health|Molar, Third
Interventions: DRUG: 21-benzyloxy-9alpha-fluoro-16alpha-methylpregna-1,4-dien-11beta,17alpha-diol-3,20-dione
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: DPP-4 Inhibitor and Serum BNP Level of Diabetic Patients With Congestive Heart Failure
Status: COMPLETED
Conditions: Heart Failure|Diabetes Mellitus
Interventions: DRUG: Suspending DPP-4 inhibitor, in outpatient service|DRUG: Starting DPP-4 inhibitor after treatment of heart failure|DRUG: Suspending DPP-4 inhibitor after treatment of heart failure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Combination of Plant Extracts (BSL_EP025) in Cardiovascular Health
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: Combination of Plant Extracts (BSL_EP025)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Pilot Study of Tumor Cell Vaccine for High-risk Solid Tumor Patients Following Stem Cell Transplantation
Status: COMPLETED
Conditions: Sarcoma|Neuroblastoma|Wilm's Tumor
Interventions: BIOLOGICAL: Tumor lysate-pulsed dendritic cell (DC) vaccine|OTHER: Hematopoietic stem cell transplantation (HSCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Oral Clofarabine Administered Daily for 5 Days in Adult Patients With Refractory Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: clofarabine (oral formulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a Quadrivalent Meningococcal Conjugate Vaccine in Subjects Aged 56 and Older
Status: COMPLETED
Conditions: Meningitis|Meningococcal Meningitis|Meningococcal Infections|Invasive Meningococcal Disease
Interventions: BIOLOGICAL: Meningococcal Polysaccharide (A, C, Y, and W 135) Tetanus Protein Conjugate Vaccine|BIOLOGICAL: Meningococcal Polysaccharide Vaccine, Groups A, C, Y, W 135 Combined
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating Abemaciclib + Aromatase Inhibitors in HR+, HER2- Advanced Breast Cancer Patients (HERMIONE-7)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Breast Cancer
Interventions: DRUG: Abemaciclib|DRUG: Aromatase Inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of Different Formulations of GlaxoSmithKline (GSK) Biologicals H7N1 Influenza Vaccine Administered to Adults 21 to 64 Years of Age
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Investigational H7N1 vaccine GSK2789869A|BIOLOGICAL: Investigational H7N1 vaccine GSK2789868A|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Early Versus Late Monitoring Among Pregnant Women With a History of Gestational Diabetes
Status: RECRUITING
Conditions: Pregnancy Complications|Gestational Diabetes
Interventions: DEVICE: continuous blood glucose monitoring in a subset of women (n=25) in the early monitoring group.|OTHER: Collection of urine, maternal blood at baseline and 28 weeks in a subset of women (n=25)|OTHER: Collection of umbilical cord blood, placental samples and cord tissue in a subset of women (n=25)|OTHER: Maternal and neonatal outcome data collection for all women in the study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Single Dose Escalation Study of 131I-Sibrotuzumab in Patients With Advanced or Metastatic Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: 131I-Sibrotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT With 3 Different Biomaterials for Maxillary Sinus Lift
Status: COMPLETED
Conditions: Alveolar Bone Atrophy
Interventions: PROCEDURE: Maxillary Sinus Augmentation|DEVICE: Maxillary Sinus Graft with ABBM|DEVICE: Maxillary Sinus Graft with TCP|DEVICE: Maxillary Sinus Graft with TCP + HA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Integrating the Fundamentals of Care Framework Into Italian Nursing Education
Status: UNKNOWN
Conditions: Nursing Students
Interventions: OTHER: Theoretical and classroom learning interventions|OTHER: Simulation interventions|OTHER: Internship interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Analysis of Natural Killer Cell Activity (NKA) in Whole Blood in High Risk Subjects Undergoing Colonoscopy
Status: TERMINATED
Conditions: Immunity, Innate|Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: IVDD for NK cell activity in whole blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Comparison Of Outcome Of Treatment OF Topical 15%TCA VS Topical 0.05% Tretinoin In Treatment Of Acanthosis Nigricans
Status: COMPLETED
Conditions: Acanthosis Nigricans
Interventions: DRUG: Topical 15% Trichloroacetic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Randomized, Double-Blind, Double-Dummy Trial of Azithromycin SR Compared With Clarithromycin Extended Release for the Treatment of Pneumonia in Adult Patients
Status: COMPLETED
Conditions: Pneumonia
Interventions: DRUG: clarithromycin extended release (ER)|DRUG: azithromycin SR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Anesthesia for Cesarean Delivery: Bupivacaine With or Without Fentanyl
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Bupivacaine|DRUG: Bupivacaine, fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine for Bilateral Superficial Cervical Plexus Block for Reconstructive Tracheal Surgery
Status: COMPLETED
Conditions: Tracheal Reconstruction
Interventions: DRUG: Levobupivacaine|DRUG: Levobupivacaine-Dexmedetomidine|OTHER: General Anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Feasibility of SOLAR Group Program Among MHPSS Workers After the Earthquake
Status: NOT_YET_RECRUITING
Conditions: Psychological Distress|Secondary Trauma|Depression|Anxiety
Interventions: BEHAVIORAL: The Skills for Life Adjustment and Resilience (SOLAR) program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of ZG005 Combined With Bevacizumab Versus Sintilimab Combined With Bevacizumab in Advanced Hepatocellular Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: ZG005 for Injection|BIOLOGICAL: Bevacizumab|BIOLOGICAL: Sintilimab|BIOLOGICAL: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dropout Factors in Chronic Pain Management
Status: COMPLETED
Conditions: Chronic Pain
Interventions: BEHAVIORAL: Self-hypnosis/self-care group|BEHAVIORAL: Music/self-care|BEHAVIORAL: Self-care|BEHAVIORAL: Psycho-education|BEHAVIORAL: Self-hypnosis/self-care motivation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cannabinoids and Traumatic Brain Injury: A Randomized, Placebo Controlled Trial
Status: RECRUITING
Conditions: Brain Injuries, Traumatic
Interventions: DRUG: Cannabidiol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of SYNT001 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: SYNT001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Steroid Sparing Effect of Nasal Corticosteroid In Asthma And Rhinitis
Status: COMPLETED
Conditions: Asthma|Allergic Rhinitis
Interventions: DRUG: Fluticasone Evohaler pMDI|DRUG: Placebo|DRUG: Fluticasone Evohaler|DRUG: Placebo intranasal spray|DRUG: fluticasone propionate (Flixonase®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Heart Rate Variability (HRV)-Guided Transcranial Direct Current Stimulation (tDCS)
Status: NOT_YET_RECRUITING
Conditions: Depression
Interventions: DEVICE: Active Transcranial Direct Current Stimulation (tDCS)|DEVICE: Sham Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Diode Laser With Periodontal Flap Surgery in Periodontitis
Status: COMPLETED
Conditions: Periodontitis, Aggressive|Diode Laser Therapy|Periodontal Diseases
Interventions: DEVICE: Diode Laser|PROCEDURE: Modified Widman Flap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bendamustine, Mitoxantrone, and Rituximab (BMR) for Patients With Untreated High Risk Follicular Lymphoma
Status: TERMINATED
Conditions: Follicular Lymphoma
Interventions: DRUG: Bendamustine|DRUG: Mitoxantrone|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiotherapist Approach to Shoulder's Diseases, Differences Between Fascial Manipulation and Standard Exercises
Status: COMPLETED
Conditions: Shoulder Pain|Manual Therapy
Interventions: OTHER: Fascial Manipulation|OTHER: Standard exercises protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single-Dose Local Radiation Therapy Compared With Ibandronate in Treating Patients With Localized Metastatic Bone Pain
Status: COMPLETED
Conditions: Metastatic Cancer|Pain|Prostate Cancer
Interventions: DRUG: ibandronate sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Two Active Lactobacilli for the Maintenance of Gingival Health
Status: WITHDRAWN
Conditions: Gingivitis
Interventions: DIETARY_SUPPLEMENT: Probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Efficacy and Safety of QL0911 in Chemotherapy- Induced Thrombocytopenia
Status: COMPLETED
Conditions: Chemotherapy-induced Thrombocytopenia
Interventions: DRUG: QL0911
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Homeopathic Treatment for Hot Flashes in Non Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: BRN01|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Muscarinic Receptor Antagonists as a Therapy for Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetic; Neuropathic, Polyneuropathy (Manifestation)
Interventions: DRUG: 3% oxybutynin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Zoliflodacin in Uncomplicated Gonorrhoea
Status: COMPLETED
Conditions: Gonorrhea
Interventions: DRUG: zoliflodacin|DRUG: ceftriaxone|DRUG: azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Two Different Dosages of Remifentanil During Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: Remifentanil|DRUG: Remifentanil|DRUG: Meperidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Efficacy and Safety of QVM149 (Indacaterol Acetate / Glycopyrronium Bromide / Mometasone Furoate) Versus Salmeterol Xinafoate/Fluticasone Propionate in Children From 12 Years to Less Than 18 Years of Age With Asthma.
Status: NOT_YET_RECRUITING
Conditions: Asthma
Interventions: DRUG: QVM149|DRUG: Salmeterol Xinafoate / Fluticasone Propionate|DRUG: Placebo to QVM149|DRUG: Placebo to Salmeterol Xinafoate / Fluticasone Propionate|DRUG: Run-In Medication|DRUG: Rescue Medication|DEVICE: Concept 1 Device|DEVICE: Girohaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sleep in SNOO Smart Sleeper Bassinet in Preterm Infants
Status: RECRUITING
Conditions: Prematurity|Very Preterm Maturity of Infant
Interventions: DEVICE: SNOO Smart Sleeper|DEVICE: Traditional bassinet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Study of the Efficacy of Laser Acupuncture on Osteoarthritis Knees by Using Magnetic Resonance Imaging, Clinical Evaluation, and Movement Analysis
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: LA-400 laser acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mantram Repetition to Manage PTSD in Veterans
Status: COMPLETED
Conditions: Stress Disorders, Post Traumatic
Interventions: BEHAVIORAL: Mantram Repetition Program (MRP) plus Usual Care|OTHER: Usual care consisting of medication and case management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Amoxicillin Plus Metronidazole in Periodontal Maintenance
Status: ENROLLING_BY_INVITATION
Conditions: Periodontitis|Periodontal Pocket
Interventions: DRUG: Amoxicillin 500 milligrams capsules plus metronidazole 400 milligrams|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Disease
Status: COMPLETED
Conditions: Cardiac Toxicity|Lymphoma
Interventions: BIOLOGICAL: bleomycin sulfate|BIOLOGICAL: filgrastim|DRUG: dexrazoxane hydrochloride|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: vincristine sulfate|RADIATION: low-LET cobalt-60 gamma ray therapy|RADIATION: low-LET electron therapy|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Change in Skin Surface Temperature at the Knee Area on Both Sides When Using Mild Moxibustion Manipulation at Mingmen Acupoint With Moxa Stick
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: PROCEDURE: Mild moxibustion with moxa stick
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ablative Radiosurgery vs Stereotactic RT in 5 Fractions With SIB for Oligometastatic Bone Lesions
Status: RECRUITING
Conditions: Oligometastatic Disease
Interventions: RADIATION: radiosurgery and stereotactic ablative radiotherapy with simultaneous integrated boost, respectively
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glucagon Counterregulation in Type 1 Diabetes
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus
Interventions: OTHER: Basal insulin alone|OTHER: Basal pramlintide and reduced basal insulin|OTHER: CGM|OTHER: Acetaminophen test|OTHER: Insulin-induced hypoglycemia|OTHER: Exercise-induced hypoglycemia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Randomized Amifostine For SCCHN
Status: COMPLETED
Conditions: Chemotherapeutic Agent Toxicity|Head and Neck Cancer|Mucositis|Radiation Toxicity|Xerostomia
Interventions: DRUG: Amifostine|DRUG: Carboplatin|DRUG: Paclitaxel|RADIATION: radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Nasogallbladder Drainage Versus Gallbladder Stenting Before Cholecystecomy
Status: COMPLETED
Conditions: Cholecystitis, Acute|Common Bile Duct Calculi
Interventions: DEVICE: 7-Fr Pigtail type naso-cholecystic drainage tube (Liguory nasal biliary drainage set; Wilson-Cook Medical, Salem, NC, USA)|DEVICE: 7-Fr double pigtail plastic stent (Zimmon; Wilson-Cook Medical, Salem, NC, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virus-specific ImmunoTherapy Following Allogeneic Stem Cell Transplantation
Status: WITHDRAWN
Conditions: Cytomegalovirus Infection|Adenovirus Infection
Interventions: BIOLOGICAL: virus-specific T-Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Response to Different Lymphoedema Compression Programs Using a Pneumatic Compression Device
Status: COMPLETED
Conditions: Lower Extremity Lymphoedema|Leg Lymphoedema
Interventions: DEVICE: pneumatic compression - 1 hour per day|DEVICE: pneumatic compression - 2 hours per day|DEVICE: pneumatic compression - 4 hours per day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Probiotics on Radiation Enteritis Stage Ⅱ Induced by Pelvic Concurrent Chemoradiotherapy
Status: RECRUITING
Conditions: Pelvic Cancer, Enteritis, Probiotics,Chemoradiotherapy
Interventions: OTHER: probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of EPI-7386 in Combination With Abiraterone Acetate Plus Prednisone, or Apalutamide in Metastatic Castration-resistant Prostate Cancer (mCRPC)
Status: TERMINATED
Conditions: Prostatic Neoplasms
Interventions: DRUG: EPI-7386|DRUG: Abiraterone Acetate|DRUG: Prednisone or Prednisolone|DRUG: Apalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Conventional and CAD/CAM Dental Restorations
Status: UNKNOWN
Conditions: Dental Caries|Tooth Fractures|Tooth Resorption
Interventions: DEVICE: CAD/CAM manufactured fixed unitary dental prostheses|DEVICE: Conventionally manufactured unitary dental prostheses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of In-vivo Wear Between 28 mm and 40 mm Metal Heads
Status: TERMINATED
Conditions: Arthroplasty, Replacement, Hip
Interventions: DEVICE: Trident cup, X3 inserts, 28 mm head|DEVICE: Trident cup, X3 inserts, 40 mm head|DEVICE: Symax stem|DEVICE: Accolade TMZF stem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ferritin Screening And IRon Treatment for Maternal Anemia and FGR Prevention Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Iron Deficiency (Without Anemia)|Pregnancy Related
Interventions: DRUG: Parentral Iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Dexmedetomidine and Coronary Artery Bypass Graft Surgery
Status: RECRUITING
Conditions: Acute Kidney Injury
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial to Study the Effects of Dietary Flax Beverage on Memory and Cognition
Status: ACTIVE_NOT_RECRUITING
Conditions: Memory; Disturbance, Mild
Interventions: DIETARY_SUPPLEMENT: flaxseed beverage|DIETARY_SUPPLEMENT: control beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Microcurrent and Aerobic Exercise Effects in Abdominal Fat
Status: COMPLETED
Conditions: Obesity, Abdominal
Interventions: DEVICE: Transcutaneous microcurrent|DEVICE: Aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial of Fluticasone Versus Placebo at the Onset of a Cold for Children With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: inhaled fluticasone 750 mcg/day twice daily until 2 days without symptoms (maximum 15 consecutive days)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Study of Nasonex in Patients With Moderate to Severe Persistent Allergic Rhinitis and Intermittent Asthma
Status: COMPLETED
Conditions: Allergic Rhinitis|Asthma
Interventions: DRUG: Mometasone furoate nasal spray (MFNS)|DRUG: Placebo nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determine the Safety of a Sublingual Tablet Formulation of Buprenorphine and Naloxone by Extending the Combination Tablet Availability to Physicians in Office-Based Practice
Status: COMPLETED
Conditions: Opiate Dependence
Interventions: DRUG: naloxone|DRUG: buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REcovery From DEXmedetomidine-induced Unconsciousness
Status: NOT_YET_RECRUITING
Conditions: Anesthesia|Healthy|Consciousness, Level Altered
Interventions: DEVICE: Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Overnight Low Oxygen Exposure on Energy Balance
Status: COMPLETED
Conditions: Resting Metabolic Rate|Appetite|Heart Rate Variability
Interventions: DEVICE: Normobaric Hypoxia|DEVICE: Normobaric Normoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hand Hygiene Randomized Cluster Intervention to Reduce Infections
Status: COMPLETED
Conditions: Respiratory Tract Infections|Gastrointestinal Infections
Interventions: BEHAVIORAL: Hand Hygiene Improvement Intervention|BEHAVIORAL: Ask Me 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Perioperative UtiLisation of SupplEmental Oxygen
Status: ACTIVE_NOT_RECRUITING
Conditions: Anesthesia
Interventions: DRUG: Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: e-Health Program to Prevent Exacerbations in the Cystic Fibrosis Population
Status: NOT_YET_RECRUITING
Conditions: Cystic Fibrosis
Interventions: BEHAVIORAL: Exercise plus Monitoring Group (TG-2)|BEHAVIORAL: Exercise plus monitoring and follow-up group (TGF-3)|BEHAVIORAL: Exercise Group (CG-1)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety & Efficacy of Adipose-Derived Regenerative Cells in the Treatment of Chronic Myocardial Ischemia (ATHENA II)
Status: COMPLETED
Conditions: Myocardial Ischemia
Interventions: DEVICE: Celution System|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Single Versus Double Foley's Catheter in Pre-induction Cervical Ripening
Status: UNKNOWN
Conditions: Post Date|Induction of Labor
Interventions: DEVICE: single versus double Foley's catheter in pre-induction cervical ripening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparing Immune Response of 2 vs 3 HPV Doses (27-45 Years Old)
Status: RECRUITING
Conditions: Immunization|HPV Infection|Human Papillomavirus
Interventions: BIOLOGICAL: 9-valent HPV vaccine, 2 doses alternate timing|BIOLOGICAL: 9-valent HPV vaccine, 3 doses standard timing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION