pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: In Vivo Liquid Biopsy of Melanoma (Cytophone)
Status: NOT_YET_RECRUITING
Conditions: Melanoma|Circulating Tumor Cells|Metastatic Melanoma|Diagnosis
Interventions: DEVICE: Cytophone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Impact of a Nutritional Supplement Made of Vegetable Oils in People at Risk of Diabetes
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: Full dose supplement|DIETARY_SUPPLEMENT: Low dose Supplement|OTHER: Control Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of HIIT on Bone Metabolism in Individuals With Chronic Stroke
Status: NOT_YET_RECRUITING
Conditions: Stroke|Bone Loss
Interventions: OTHER: High-intensity interval training group|OTHER: Moderate-intensity continuous training group|OTHER: Stretching group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Homeopathy Assessment in Terms of the Consumption of Analgesics After Knee Ligamentoplasty
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: Arnica montana, 5 CH|DRUG: Bryonia alba, 5 CH|DRUG: Hypericum perforatum, 5 CH|DRUG: Ruta graveolens, 3 DH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Photobiomodulation in Oral Lesions Resulting From Anti-neoplastic Prevention
Status: COMPLETED
Conditions: Oral Mucositis|Osteoradionecrosis|Osteonecroses, Bisphosphonate|Osteonecrosis Due to Drugs, Jaw|Hyposalivation|Head and Neck Cancer|Oral Cancer
Interventions: DEVICE: Preventive, LLL Phototherapy and topical Vit E|DEVICE: Curative, LLL Phototherapy and topical Vit E|DEVICE: Preventive, LLL Phototherapy and LPRF|DEVICE: Curative, LLL Phototherapy and LPRF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SDF Modified Hall Technique Vs. Conventional Pulpotomy for Management of Carious Primary Molars
Status: UNKNOWN
Conditions: Deep Carious Lesions
Interventions: DEVICE: SDF modified Hall technique|DEVICE: Conventional pulpotomy and stainless steel crown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Management After Cardiac Surgery - Opioids or NSAID
Status: COMPLETED
Conditions: Postoperative Pain|Renal Insufficiency|Myocardial Infarction
Interventions: DRUG: Ibuprofene|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Therapy on Phrenic Nerve Function
Status: RECRUITING
Conditions: Pulmonary Function Test|Phrenic Nerve Irritation|Cervical Disc Lesion
Interventions: DEVICE: Ultrasound (Phyaction 190 I); with a frequency of 3 MHz was used
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Behavioral Activation + Occupational Therapy: An Innovative Intervention for Empowered Self-Management of Multiple Chronic Conditions
Status: RECRUITING
Conditions: Multiple Chronic Conditions|Disability Physical
Interventions: BEHAVIORAL: Behavioral Activation + Occupational Therapy|BEHAVIORAL: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Oral Boldo in Women With Overactive Bladder
Status: ENROLLING_BY_INVITATION
Conditions: Urinary Bladder, Overactive
Interventions: DRUG: Oxybutynin Pill|DIETARY_SUPPLEMENT: Boldo supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of an Infant Formula Supplemented With Galacto-oligosaccharides, Beta-palmitate and Acidified Milk
Status: COMPLETED
Conditions: Formula Feeding of Healthy Full Term Infants
Interventions: OTHER: Infant formula with GOS, beta-palmitate, acidified milk|OTHER: Standard infant formula without functional ingredients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Six Sessions CBT for Adolescents With Emotional Problems in Community Clinics
Status: COMPLETED
Conditions: Generalized Anxiety Disorder|Social Phobia|Agoraphobia|Depression|Panic Disorder
Interventions: BEHAVIORAL: SMART manual cognitive behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Turquoise and Blue Light in Treatment of Neonatal Jaundice Using Light Emission Diodes
Status: COMPLETED
Conditions: Uncomplicated Neonatal Hyperbilirubinemia
Interventions: OTHER: Phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stress and Inflammation in Late-Life Depression
Status: COMPLETED
Conditions: Depression|Inflammation
Interventions: DRUG: Escitalopram + Celecoxib|DRUG: Escitalopram + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 2D Versus 3D Radical Laparoscopic Hysterectomy for Endometrial Cancer: a Prospective Randomized Trial
Status: COMPLETED
Conditions: Endometrial Cancer
Interventions: PROCEDURE: 3D Laparoscopy|PROCEDURE: Standard Laparoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccination Education Through Pharmacists and Senior Centers (VEPSC)
Status: COMPLETED
Conditions: Infectious Disease|Pneumonia, Bacterial|Influenza|Zoster; Herpes
Interventions: BEHAVIORAL: Pharmacist-led Intervention (PHARM)|BEHAVIORAL: Peer-led Intervention (PEER)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of an Integrative Day-care Clinic Program for Breast Cancer Patients During Chemotherapy
Status: COMPLETED
Conditions: Breast Cancer|Chemotherapy|Mind-Body-Medicine|Acupuncture|Quality of Life
Interventions: BEHAVIORAL: Integrative mind-body-medicine group program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Vitamin D Supplementation on COVID-19 Vaccine Response and IgG Antibodies in Deficient Women.
Status: COMPLETED
Conditions: COVID-19 Pandemic|D Vitamin Deficiency|Antibody Hypersensitivity
Interventions: DIETARY_SUPPLEMENT: Vitamin D supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Establishing 18F PMPBB3 (APN 1607) PET Imaging Markers for Diagnosis of Tauopathy Parkinsonism Syndromes
Status: UNKNOWN
Conditions: Tau Distributions in Patients With Tauopathy Using APN-1607 PET Scan
Interventions: DIAGNOSTIC_TEST: 18F-PMPBB3 (APN-1607) PET imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine
Status: RECRUITING
Conditions: Acute Disease|Sepsis|Pneumonia|Frailty|Complication of Treatment|Pulmonary Embolism|Thrombosis|Acute Kidney Injury|Electrolyte Disturbance|Hemorrhage|Shock|Polypharmacy|Intoxication by Drug|Emergencies|Urinary Tract Infections|Skin Infection|Syncope|Anaphylaxis|Dyspnea
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Analgesia After Laparoscopic Cholecystectomy
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: USG-STAP with bupivacaine and dexmedetomidine|DRUG: IP bupivacaine and dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Role of the Interaction Between Advanced Glycation End Products and Their Receptor RAGE in the Development and the Progression of the Uremic Vasculopathy of Hemodialyzed Patients
Status: COMPLETED
Conditions: Hemodialyzed Patients
Interventions: OTHER: Vascular calcifications by Xray|OTHER: Vascular calcifications by tomodentimetry|BIOLOGICAL: Blood sample withdrawn
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Appropriate Inhaler Use of Tiotropium as add-on Therapy in Symptomatic Asthma
Status: UNKNOWN
Conditions: Asthma
Interventions: OTHER: Correct/recheck strategy|OTHER: Usual verbal instruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Revised Hypertrophic Scars
Status: UNKNOWN
Conditions: Hypertrophic Scar
Interventions: DRUG: RXI-109
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharyngeal Muscle Control Mechanisms of Atomoxetine-plus-oxybutynin in Obstructive Sleep Apnea
Status: NOT_YET_RECRUITING
Conditions: OSA
Interventions: DRUG: Atomoxetine 80 mg plus Oxybutynin 5 mg|DRUG: Atomoxetine 80 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: European Nutrition in Glaucoma Management Trial
Status: COMPLETED
Conditions: Glaucoma, Open-Angle
Interventions: DIETARY_SUPPLEMENT: 10 mg Lutein, 2 mg zeaxanthin, 10 mg meso-zeaxanthin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Efficacy and Dose-response of GSK2831781 in Ulcerative Colitis
Status: TERMINATED
Conditions: Colitis, Ulcerative
Interventions: DRUG: GSK2831781 - Double Blind Phase|DRUG: Placebo|DRUG: GSK2831781 - Open Label phase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Combination Therapy of Microneedling and Minoxidil in Androgenetic Alopecia of Indonesian Men
Status: COMPLETED
Conditions: Androgenetic Alopecia
Interventions: DRUG: Minoxidil 5% Topical Solution|DEVICE: microneedling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NBP in Adult Patients With Acute Ischemic Stroke (AIS)
Status: COMPLETED
Conditions: AIS
Interventions: DRUG: NBP Softgel Capsules|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Glaucoma Rehabilitation With Action viDeo Games and Exercise - GRADE
Status: RECRUITING
Conditions: Glaucoma|Visual Impairment
Interventions: BEHAVIORAL: Action video game training|BEHAVIORAL: Conventional physical training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Gait-Training Using Wearable Sensors
Status: COMPLETED
Conditions: Shin Splint|Running-related Injury
Interventions: BEHAVIORAL: In-Field Gait-Training|BEHAVIORAL: Home Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Interventricular Septal Puncture for Cardiac Resynchronization Therapy to Treat Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: PROCEDURE: Trans-ventricular-septal placement of LV pacing lead|OTHER: Pre-procedure speckle-tracking echocardiography|OTHER: Acute response assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Preferential Left Ventricular Pacing on Ventriculoarterial Coupling and Clinical Course of Heart Failure
Status: NOT_YET_RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: DEVICE: Preferential left ventricular pacing|DEVICE: Biventricular pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-Steroidal Anti-inflammatory Drugs in Axial Spondyloarthritis
Status: TERMINATED
Conditions: Ankylosing Spondylitis|Axial Spondyloarthritis
Interventions: DRUG: Indomethacin|DRUG: Diclofenac|DRUG: Meloxicam|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double Blind Trial of LdT (Telbivudine) Versus Lamivudine in Adults With Compensated Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: telbivudine or lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Low Dose Infliximab in Ankylosing Spondylitis (Study P04352)
Status: COMPLETED
Conditions: Spondylitis, Ankylosing
Interventions: BIOLOGICAL: infliximab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Comparison of Cold Polypectomy and Conventional Polypectomy for Small Colorectal Polyps in Patients Taking Antithrombotic Agents
Status: COMPLETED
Conditions: Colorectal Polyps
Interventions: PROCEDURE: Cold polypectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Treatment for Vitamin D Deficiency on Thyroid Function and Autoimmunity in Hashimoto's Thyroiditis.
Status: UNKNOWN
Conditions: Hashimoto Disease|Treatment Levothyroxine|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D-correction|DIETARY_SUPPLEMENT: Vitamin D-RDA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Salbutamol in the Pediatric Emergencies: Nebulization Estimated Via AerogeN or Jet
Status: UNKNOWN
Conditions: Asthma
Interventions: DEVICE: vibrating Mesh nebulizer|DEVICE: jet nebulizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Bone Marrow Transplantation vs Standard of Care in Patients With Severe Sickle Cell Disease (BMT CTN 1503)
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: Busulfan|DRUG: Fludarabine|DRUG: r-ATG|PROCEDURE: Hematopoietic Cell Transplant|DRUG: Tacrolimus|DRUG: Methotrexate|PROCEDURE: Standard of Care|DRUG: Alemtuzumab|DRUG: Total Body Irradiation (TBI)|DRUG: Sirolimus|DRUG: Melphalan|DRUG: G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Circulating Tumor DNA Methylation Guided Postoperative Follow-up Strategy for Non-metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Non-metastatic Colorectal Cancer|Circulating Tumor DNA Methylation
Interventions: DIAGNOSTIC_TEST: ctDNA methylation dynamic monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate a Potential PET Radioligand for Imaging Alpha-synuclein Deposits in the Brain
Status: ACTIVE_NOT_RECRUITING
Conditions: Alpha-Synucleinopathy|Parkinson's Disease|Dementia With Lewy Bodies|Multisystem Atrophy
Interventions: DRUG: [18F]MNI-1216
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Health Information Package Program on Knowledge and Compliance Among Pregnant Women With Anemia
Status: COMPLETED
Conditions: Knowledge|Anemia|Pregnant Women
Interventions: OTHER: Health Information Package Program (HIP program )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Objective Confirmation of thе Anti-ischemic Effectiveness of Trimetazidine 80mg Once Daily in Patients With Stable Angina Who Had a History of Myocardial Infarction (METHOD)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: OTHER: speckle tracking mode of the stress ECHO test with dobutamine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: External-Beam Radiation Therapy Plus Implanted Radiation Therapy in Treating Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: RADIATION: brachytherapy|RADIATION: iodine I 125|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Aquamantys for Reducing Transfusions With Anterior Supine Intermuscular Approach Total Hip Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis, Hip|Joint Deformities, Acquired|Hip Dislocation, Congenital|Osteonecrosis|Arthritis, Rheumatoid
Interventions: DEVICE: Aquamantys|DEVICE: standard electrocautery (Bovie)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stretta In Reflux Uncontrolled by IPP
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: OTHER: Stretta procedure|OTHER: Sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Transplant Following Low-Intensity Chemotherapy to Treat Chronic Granulomatous Disease
Status: COMPLETED
Conditions: Chronic Granulomatous Disease
Interventions: DEVICE: Nexell Isolex with T-cell Depletion|DEVICE: Baxter isolex 300i
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Patients With Zollinger-Ellison Syndrome and Tumors of the Pancreas
Status: COMPLETED
Conditions: Islet Cell Adenoma|Neoplasm Metastasis|Zollinger Ellison Syndrome
Interventions: DRUG: combined chemotherapy with streptozotocin, 5-fluorouracil, and doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Gemcitabine With or Without WX-671 in Treating Patients With Locally Advanced Pancreatic Cancer That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: Serine Proteinase Inhibitor WX-671|DRUG: Serine Proteinase Inhibitor WX-671
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dynamic Contrast Enhancement Computed Tomography Based Technic to Assess Gastro Intestinal Wall Perfusion : Feasibility Study
Status: COMPLETED
Conditions: Mesenteric Ischemia|Permeability CT Technics
Interventions: RADIATION: Dynamic contrast enhanced computerised tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Nutritional Products for People With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: enteral nutritional formula|OTHER: Diabetes specific enteral product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diuretics and Angiotensin-Receptor Blocker Agents in Patients With Stage I Hypertension
Status: COMPLETED
Conditions: Hypertension|Cardiovascular Disease
Interventions: DRUG: losartan|DRUG: Chlorthalidone plus amiloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-Eluting Balloons vs Mimetic Stents for Popliteal Artery Disease
Status: RECRUITING
Conditions: Popliteal Arterial Stenosis
Interventions: DEVICE: Pharmacoactive balloon angioplasty. Lutonix®|DEVICE: Mimetic stent.Supera®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin Extended Release Versus Metformin Immediate Release in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Metformin IR|DRUG: Metformin XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Features and Pathways in Predicting Drug Resistance in Patients With Metastatic Castration-Resistant Prostate Cancer Receiving Enzalutamide
Status: COMPLETED
Conditions: Castration Levels of Testosterone|Castration-Resistant Prostate Carcinoma|Prostate Adenocarcinoma|PSA Progression|Recurrent Prostate Carcinoma|Stage IV Prostate Cancer
Interventions: OTHER: Cytology Specimen Collection Procedure|DRUG: Enzalutamide|OTHER: Laboratory Biomarker Analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Motor Activity, Cardiopulmonary Performance Capacity and Quality of Life in Patients Born With a Congenital Abdominal Wall Defect
Status: COMPLETED
Conditions: Abdominal Wall Defect
Interventions: DIAGNOSTIC_TEST: CombynTM Function & Spaces ECG|DIAGNOSTIC_TEST: Blood Taking|DIAGNOSTIC_TEST: Spiroergometry|DIAGNOSTIC_TEST: Dordel Koch Test (DKT)|DIAGNOSTIC_TEST: Ultrasound|DIAGNOSTIC_TEST: Stance and gait analyses
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lanreotide Combined With Telotristat Ethyl or Placebo for the First-line Treatment in Patients With Advanced Well Differentiated Small Intestinal Neuroendocrine Tumours (siNET) With Highly-functioning Carcinoid Syndrome
Status: WITHDRAWN
Conditions: Small Intestinal NET|Carcinoid Heart Disease
Interventions: DRUG: Telotristat Ethyl|DRUG: Lanreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Omentopexy on Gastro-oesophageal Reflux Following Sleeve Gastrectomy
Status: RECRUITING
Conditions: Obesity
Interventions: PROCEDURE: sleeve gastrectomy|PROCEDURE: sleeve gastrectomy with omentopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Understand the Treatment Patterns in Patients With Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension During a Switch of Treatment to Adempas in Real-life Clinical Practice
Status: COMPLETED
Conditions: Hypertension, Pulmonary
Interventions: DRUG: Riociguat (Adempas, BAY63-2521)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: OPALINE : A Study Of Morbidity And Mortality At 2 Years
Status: COMPLETED
Conditions: Pancreatic Neuroendocrine Tumor, Well Differentiated and Progressive
Interventions: DRUG: sunitinib|DRUG: everolimus|DRUG: chemotherapies recommended in france
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sodium Pyruvate Nasal Spray Treatment of COVID-19 Infection
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Sodium Pyruvate|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Application of Transversus Abdominis Plane Block Plus Rectus Sheath Block in Clinical Anesthesia
Status: UNKNOWN
Conditions: Postoperative Nausea and Vomiting|Surgery|Anesthesia|Peritoneal Dialysis|Rectus Sheath Block
Interventions: DRUG: Sulfentanyl|DRUG: Nalbuphine|DRUG: flubiprofen axetil|PROCEDURE: rectus sheath block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Avastin (Bevacizumab) Plus Adriamycin, Bleomycin, Vinblastine and Dacarbazine (ABVD) for Advanced Stage Hodgkin Lymphoma
Status: TERMINATED
Conditions: Hodgkin Lymphoma
Interventions: DRUG: Avastin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Immunoglobulins in Complex-regional Pain Syndrome
Status: WITHDRAWN
Conditions: Complex Regional Pain Syndrome Type 1
Interventions: BIOLOGICAL: intravenous immunoglobulins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Umbilical Cord Mesenchymal Stem Cells Infusion for Initial Type 1 Diabetes Mellitus
Status: UNKNOWN
Conditions: Diabetes Mellitus|Diabetes Mellitus, Type 1|Mesenchymal Stem Cells|Umbilical Cord
Interventions: BIOLOGICAL: umbilical cord mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Venous Thromboembolism in Patients With Acute Primary Intracerebral Hemorrhage
Status: UNKNOWN
Conditions: Intracerebral Hemorrhage
Interventions: DRUG: enoxaparin|DRUG: enoxaparin placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Three Lifestyle Interventions on Endothelial Function and Cardiometabolic Risk in Obese Patients With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome|Obesity
Interventions: BEHAVIORAL: hypocaloric diet|BEHAVIORAL: Exercise recommendations|BEHAVIORAL: Pragmatic diet|BEHAVIORAL: Pedometer-based fitness (10,000 steps)|BEHAVIORAL: Structured assisted exercise (fitness)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Cord Blood Derived Mesenchymal Stem Cells for Treatment of Moderate, Severe or Critical Pneumonia
Status: RECRUITING
Conditions: COVID-19 Infection|COVID-19-Associated Acute Respiratory Distress Syndrome|Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm|Symptomatic COVID-19 Infection Laboratory-Confirmed
Interventions: OTHER: Best Practice|BIOLOGICAL: Mesenchymal Stem Cell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3, Randomized Study of Apremilast in Japanese Participants With Palmoplantar Pustulosis (PPP)
Status: COMPLETED
Conditions: Palmoplantar Pustulosis
Interventions: DRUG: Apremilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy With IFx-Hu2.0 Vaccine for Advanced Non-melanoma Skin Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Merkel Cell Carcinoma|Cutaneous Squamous Cell Carcinoma|Non-Melanoma Skin Cancers
Interventions: BIOLOGICAL: IFx-Hu2.0
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ARIADE : Augmented Reality for Improving Autonomy in Dementia
Status: COMPLETED
Conditions: Alzheimer or Mild Cognitive Impairment
Interventions: OTHER: Augmented reality technological assistance for the movements of people with Alzheimer's disease or MCI in a controlled environment.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Peripheral Immune System in Individuals With Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia|Schizo Affective Disorder|Schizophreniform Disorders
Interventions: DIAGNOSTIC_TEST: SCID (Standardized Clinical Interview for DSM-V)|DIAGNOSTIC_TEST: PSS (Perceived Stress Score)|DIAGNOSTIC_TEST: Urine Toxicology Screen|DIAGNOSTIC_TEST: Vitals|DIAGNOSTIC_TEST: Blood Work|DIAGNOSTIC_TEST: PQ-B|DIAGNOSTIC_TEST: COVID Screening|DIAGNOSTIC_TEST: Positive and Negative Syndrome Scale (PANSS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of BDTX-189, an Orally Available Allosteric ErbB Inhibitor, in Patients With Advanced Solid Tumors.
Status: TERMINATED
Conditions: Solid Tumor
Interventions: DRUG: BDTX-189
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Analgesia Nociception Index and Videopupillometry to Predict a Child's Post-tonsillectomy Morphine Prescription
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: OTHER: Nerve stimulation of the ulnar nerve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Childhood Trauma, Exercise, and Cognition
Status: RECRUITING
Conditions: Adverse Childhood Experiences
Interventions: BEHAVIORAL: Moderate Intensity Exercise (one day)|BEHAVIORAL: Placebo - Light Intensity Exercise (one day)|BEHAVIORAL: Moderate Intensity Exercise (9 wks)|OTHER: Day 1 Assessments|OTHER: Symptom Measures and Neuropsychological Tests|OTHER: Day 36 Assessments|OTHER: Day 57 Assessments|OTHER: Day 78 Assessments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Reattachment of the SPR Versus the Bone Block Procedure for Recurrent Peroneal Tendon Dislocation
Status: COMPLETED
Conditions: Recurrent Peroneal Tendon Dislocation
Interventions: PROCEDURE: bone block procedure|PROCEDURE: Reattachment of the superior peroneal retinaculum
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of CSE and ISE on Pain, Strength, Flexibility, Disability and QoL in Patients With CDH
Status: COMPLETED
Conditions: Cervical Disc Herniation
Interventions: OTHER: segmental cervical stabilization exercises|OTHER: cervical isometric exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of PD-1 Antibody Combined With Chemoradiotherapy in Oligometastatic Esophageal Cancer
Status: UNKNOWN
Conditions: Esophagus Cancer|Chemoradiotherapy|Oligometastatic Disease|Immunotherapy
Interventions: DRUG: PD-1 antibody|RADIATION: Chemoradiation|DRUG: Albumin-Bound Paclitaxel|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study of MM-398 Plus Irinotecan in Patients With Unresectable Advanced Cancer
Status: COMPLETED
Conditions: Unresectable Advanced Cancer
Interventions: DRUG: MM-398|DRUG: Irinotecan|DRUG: Leucovorin (LV)|DRUG: 5-fluorouracile (5-FU)|DRUG: bevacizumab|DRUG: MM-398
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Hawthorn on Lipoprotein Cholesterol Ratio in Schizophrenics With Antipsychotics
Status: COMPLETED
Conditions: Schizophrenia
Interventions: OTHER: Hawthorn|DRUG: SGAs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Partially Hydrolyzed Guar Gum in Improving Fecal Characteristics in Long Term Care Facility Residents
Status: UNKNOWN
Conditions: Constipation
Interventions: DIETARY_SUPPLEMENT: Partially hydrolyzed guar gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Betalactam Antibiotics in Prolonged Infusion Compared to Intermittent in Pediatric Patients With Sepsis
Status: COMPLETED
Conditions: Sepsis
Interventions: DRUG: Intermittent Piperacillin/tazobactam|DRUG: Continuous Piperacillin/tazobactam|DRUG: Intermittent Imipenem|DRUG: Extended Imipenem|DRUG: Intermittent Meropenem|DRUG: Extended Meropenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Chiron's Investigational H. Pylori Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Helicobacter Pylori|Gastritis|Gastric Cancer|Gastroduodenal Ulcers|Lymphoma
Interventions: BIOLOGICAL: helicobacter pylori vaccine|BIOLOGICAL: helicobacter pylori vaccine|BIOLOGICAL: helicobacter pylori vaccine|BIOLOGICAL: helicobacter pylori vaccine|BIOLOGICAL: Placebo|BIOLOGICAL: helicobacter pylori vaccine|BIOLOGICAL: helicobacter pylori vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Double-blind Study to Assess effectIveness of Pectoral Nerves Block After Breast Surgery on Piritramide Consumption
Status: COMPLETED
Conditions: Locoregional Analgesia in Breast Surgery
Interventions: DRUG: Ropivacaine|DRUG: Clonidine|DRUG: Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EMEPIC : Value of a Mobile Team of Cardiologist Using Echocardiography for Managing Patients With Acute Heart Failure
Status: COMPLETED
Conditions: Acute Heart Failure|Congestive Edema|Cardiac Disease
Interventions: PROCEDURE: Mobile team|PROCEDURE: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of a New Thermo Stable Formulation of Epoprostenol Sodium to Treat Pulmonary Arterial Hypertension (PAH)
Status: COMPLETED
Conditions: Hypertension, Pulmonary
Interventions: DRUG: current marketed FLOLAN (epoprostenol sodium)|DRUG: new thermo stable formulation of epoprostenol sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Intrauterine Infusion of hCG at the Time of Embryo Transfer
Status: UNKNOWN
Conditions: Infertility
Interventions: PROCEDURE: Intrauterine hCG (pregnyl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Real-world Study of Adebrelimab Combined With Chemotherapy±Chest Radiotherapy in Patients With Extensive Stage Small Cell Lung Cancer
Status: RECRUITING
Conditions: Extensive Stage Small Cell Lung Cancer
Interventions: DRUG: Adebrelimab + chemotherapy|RADIATION: ±chest radiotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Motility of the Check-cap's MD1 Colon Capsule in Subjects Following Colon Rectal Cancer Screening by Colonoscopy
Status: COMPLETED
Conditions: Colo-rectal Cancer
Interventions: DEVICE: MDI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Feasibility of Ectoin® Inhalation Solution in Inflammatory Obstruction and Ageing of the Lung
Status: COMPLETED
Conditions: COPD|Particulate Matter Induced Inflammation of the Lung
Interventions: DEVICE: Ectoin Inhalation Solution|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative VR for Recovery After Bariatric Surgery
Status: RECRUITING
Conditions: Bariatric Surgery Candidate|Postoperative Pain|Postoperative Complications
Interventions: OTHER: Virtual Reality Immersive Relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of AFQ056 When Combined With Increased Doses of L-dopa in Parkinson's Disease Patients With Moderate-severe L-dopa Induced Dyskinesia
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: AFQ056 with L-dopa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allo Transplant Followed by Lenalidomide and Sirolimus Maintenance in High-Risk Multiple Myeloma (MM)
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Sirolimus|DRUG: Tacrolimus|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Monitoring Continuous Glucose Levels and Physical Activity Via Wearables on Cardiovascular Risk Factors
Status: RECRUITING
Conditions: Coronary Heart Disease|Physical Activity|Cardiovascular Risk Factors
Interventions: DEVICE: Fitbit Inspire 2|DEVICE: Abbott Freestyle Libre 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Single-Session Psychotherapy for Young Kids Through Patient Engagement Techniques
Status: ACTIVE_NOT_RECRUITING
Conditions: Mental Health Issue|Family Dynamics|Stress, Psychological|Stress, Emotional|Child Development
Interventions: BEHAVIORAL: SPYKids|OTHER: Services as Usual (SAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Study to Evaluate the Clinical and Economic Benefits of I-Ray in Patients With Choroidal Neovascularization Secondary to Age-related Macular Degeneration
Status: UNKNOWN
Conditions: Age-Related Macular Degeneration|Wet Macular Degeneration|Macular Degeneration|Eye Diseases|Retinal Diseases
Interventions: DEVICE: IRay
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Rising Oral Doses of BI 1356 BS Administered to Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1356 BS - Powder in bottle (PIB)|DRUG: BI 1356 BS - Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Interaction Between AZD3480 and Donepezil
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: AZD3480|DRUG: Donepezil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dose-Finding Study of Batefenterol (GSK961081) Via Dry Powder Inhaler in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Batefenterol|DRUG: Umeclidinium/ Vilanterol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Carotid Plaque Screening Trial in Smokers
Status: COMPLETED
Conditions: Smoking
Interventions: DEVICE: Carotid ultrasound for plaque screening|BEHAVIORAL: Brief advice for smoking cessation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Efficacy of Interferential Therapy in Chronic Constipation (CON-COUR)
Status: UNKNOWN
Conditions: Chronic Constipation Symptoms
Interventions: DEVICE: Flexstim IF|DEVICE: Flexstim IF faked
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Telemedicine for Improvement of Care for Older Adults With Cancer in the Underserved Community, The GAIN-S Trial
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid System Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Best Practice|OTHER: Comprehensive Geriatric Assessment|OTHER: Electronic Health Record Review|OTHER: Questionnaire Administration|OTHER: Supportive Care|OTHER: Telemedicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Longitudinal Cohort Study to Evaluate Cardiovascular Risk Factors and Disease in Haiti
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension|Diabetes|Obesity|Kidney Diseases|Dyslipidemias|Smoking|Alcohol Use, Unspecified|Physical Inactivity|Poor Diet|Inflammation|Myocardial Infarction|Heart Failure|Stroke|Cardiac Death
Interventions: OTHER: Observational Study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 8 Weeks Versus 12 Weeks of Elbasvir/Grazoprevir in Treatment-naïve CHC With Mild Fibrosis
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Zepatier Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of NAD Supplementation on Brain Vascular Health in Aging
Status: RECRUITING
Conditions: Aging
Interventions: DRUG: Nicotinamide riboside|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Incidence and Severity of Postoperative Sore Throat And Intubation Response by Using Different Devices for Endotracheal Intubation
Status: COMPLETED
Conditions: Pharyngitis|Endotracheal Intubation|Pain
Interventions: DEVICE: Endotracheal intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Moxonidine + Perindopril in Hypertensive Patients With Metabolic Syndrome
Status: UNKNOWN
Conditions: Arterial Hypertension|Metabolic Syndrome
Interventions: DRUG: perindopril + moxonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Profibrosing Role of B Lymphocytes in Patients With Systemic Sclerosis.
Status: RECRUITING
Conditions: Scleroderma, Systemic
Interventions: PROCEDURE: skin biopsy|OTHER: Blood punction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of Diagnostic Accuracy and Performance of Digital Breast Tomosynthesis Compared to Mammography
Status: COMPLETED
Conditions: Breast Cancer|Tumors, Breast|Cancer Screening
Interventions: DEVICE: FFDM|DEVICE: DBT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Neoadjuvant Pembrolizumab + Epacadostat Prior to Curative Surgical Care for Squamous Cell Carcinoma of the Head and Neck
Status: WITHDRAWN
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Pembrolizumab|DRUG: Epacadostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) and an Opioid on Ventilation
Status: COMPLETED
Conditions: Hypercapnia|Ventilatory Depression
Interventions: DRUG: Placebo and Oxycodone|DRUG: Paroxetine and Oxycodone|DRUG: Escitalopram and Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: ECG-I Targeted Ablation for Persistent AF Not Responding to Pulmonary Vein Isolation Results of a Two Staged Strategy.
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DEVICE: ECG-I Mapping of Atrial Fibrillation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: API-CAT STUDY for APIxaban Cancer Associated Thrombosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer-associated Thrombosis
Interventions: DRUG: Apixaban 5 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Perifoveal Vascular Network Assessed by OCT-Angiography in Type I Diabetes Mellitus
Status: UNKNOWN
Conditions: Retinal Vascular|Retinal Disease|Retinal Ischemia|Retinal Ischaemia Due to Type 1 Diabetes Mellitus|Diabetes Mellitus|Diabetic Retinopathy|Diabetes Mellitus, Type 1|Vessels; Retina, Tortuous
Interventions: DIAGNOSTIC_TEST: Optical Coherence Tomography Angiography|DIAGNOSTIC_TEST: Blood test|DIAGNOSTIC_TEST: Urine test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC