pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Flecainide Versus Amiodarone in the Cardioversion of Paroxysmal Atrial Fibrillation at the Emergency Department, in Patients With Coronary Artery Disease Without Residual Ischemia
Status: RECRUITING
Conditions: Atrial Fibrillation Paroxysmal|Coronary Artery Disease Without Residual Ischemia
Interventions: DRUG: Flecainide Injectable Solution|DRUG: Amiodarone Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Intermediate and Long-term Follow up of Home Based Pelvic Muscle Training
Status: RECRUITING
Conditions: Pelvic Floor Disorders|Pelvic Organ Prolapse|Stress Urinary Incontinence
Interventions: DEVICE: Home-based pelvic muscle training devices or traditional PFMT at hospital
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Unsedated Colonoscopy for Colorectal Cancer Screening and Surveillance
Status: COMPLETED
Conditions: Colon Polyp
Interventions: PROCEDURE: Water infusion in lieu of air insufflation|PROCEDURE: Air method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Abdominal Regional Perfusion in Donation After Cardiac Death for Multi-Organ Transplantation
Status: NOT_YET_RECRUITING
Conditions: Liver Transplant; Complications|Ischemia Reperfusion Injury|Cirrhosis|Liver Cancer|Liver Metastases|End Stage Liver Disease
Interventions: DEVICE: Abdominal Regional Perfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Atorvastatin in Preventing Cerebrovascular Events After Flow Diverter Implantation
Status: NOT_YET_RECRUITING
Conditions: Efficacy Endpoint: no New Cerebrovascular Adverse Events Within 1 Year|Safety Endpoint: no New Moderate or Serious Adverse Events Within 1 Year|All-cause Mortality Events (Within 1 Year)|Incident Ischemic Stroke Events (Within 1 Year)|New Hemorrhagic Stroke Events (Within 1 Year)|New Stent Thrombosis Events (Within 1 Year)|New Symptomatic Stenosis Events (Within 1 Year)|Occurrence of In-stent Stenosis 12th ±1 Month Annual Angiographic Follow-up|Degree of In-stent Stenosis (as Measured by WASID Method) at the 12th ±1 Month Annual Angiographic Follow-up|Target Aneurysm Embolization Rate at 12±1 Month Annual Angiographic Follow-up (Raymond and OKM Classification)
Interventions: DRUG: Atorvastatin 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of the Effect of n-3(Omega 3) Fortified Egg in Healthy Subjects
Status: UNKNOWN
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: eggs enriched Omega-3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigate New Surgical Techniques to Improve Esthetics and Patient Satisfaction at Implant Sites
Status: UNKNOWN
Conditions: Fractured Tooth
Interventions: PROCEDURE: socket shield technique with xenophobic graft particulate and without the use of graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proton Pump Inhibitors and Risk of Community-acquired Pneumonia
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease (GERD)|Community-acquired Pneumonia
Interventions: DRUG: esomeprazole|DRUG: omeprazole|DRUG: pantoprazole|DRUG: lansoprazole|DRUG: rabeprazole|DRUG: cimetidine|DRUG: ranitidine|DRUG: famotidine|DRUG: nizatidine|DRUG: niperotidine|DRUG: roxatidine|DRUG: ranitidine bismuth citrate|DRUG: lafutidine|DRUG: cimetidine combinations|DRUG: famotidine combinations
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rituximab & Combination Chemotherapy Followed by Transplantation in Relapsed or Refractory Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: carmustine|DRUG: cytarabine|DRUG: etoposide|DRUG: melphalan|PROCEDURE: autologous hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenomic Study in Myeloma Patients Treated With Melphalan-prednisone-thalidomide or Lenalidomide-dexamethasone
Status: COMPLETED
Conditions: Myeloma
Interventions: DRUG: melphalan-prednisone-thalidomide|DRUG: lenalidomide-dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of Two Types of Botulinum Toxin Type A For the Treatment of Glabellar Lines
Status: COMPLETED
Conditions: Glabellar Lines
Interventions: BIOLOGICAL: botulinum toxin type A|BIOLOGICAL: botulinum toxin type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pure Prone Positioning Therapy for the Patients With Mild to Moderate Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Pure prone positioning
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hand Hygiene Intervention Program on Primary School Students' Health Outcomes and Absenteeism in School
Status: COMPLETED
Conditions: Respiratory Tract; Infection, Upper (Acute)|Hand Hygiene|Absenteeism
Interventions: BEHAVIORAL: Hand hygiene intervention program developed according to planned behavior theory|BEHAVIORAL: Classical hand hygiene education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Reducing Anxiety Levels Through the Dharma Life App-Based and Mentor-Based Program Targeting Personality Characteristics: A Randomized Control Trial
Status: COMPLETED
Conditions: Anxiety
Interventions: BEHAVIORAL: App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Remote Activity Monitored by Fitbit Charge 3 in Investigating Daily Step and Sleep Data in Participants With Head and Neck Cancer Undergoing Radiation Therapy
Status: COMPLETED
Conditions: Head and Neck Carcinoma
Interventions: DEVICE: Monitoring Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Low-Level Laser Stimulation With and Without Fear Extinction Training
Status: COMPLETED
Conditions: Phobias|Claustrophobia|Social Phobia
Interventions: BEHAVIORAL: Extinction Training|DEVICE: Low-Level Laser Therapy|DEVICE: Sham Low-Level Laser Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Compare Raltegravir Versus Nevirapine as Anchor Drug for HIV+ Chinese IDUs on Methadone Maintenance
Status: UNKNOWN
Conditions: HIV|HIV Infections
Interventions: DRUG: Raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiology Optimized Versus Angio-guided PCI
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease|Percutaneous Coronary Intervention
Interventions: OTHER: Microcatheter-derived FFR|OTHER: Angiography-derived FFR|OTHER: Angiography-guided PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lidocaine, Esmolol, or Placebo to Relieve IV Propofol Pain
Status: TERMINATED
Conditions: Injection Site Irritation|Pain
Interventions: DRUG: Lidocaine|DRUG: Esmolol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Amifostine in Treating Patients With Cancer Who Have Neurological Changes Caused by Chemotherapy
Status: COMPLETED
Conditions: Drug/Agent Toxicity by Tissue/Organ|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: amifostine trihydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Juvidex (Mannose-6-Phosphate) in Accelerating the Healing of Split Thickness Skin Graft Donor Sites
Status: COMPLETED
Conditions: Wound
Interventions: DRUG: Mannose-6-Phosphate (Juvidex)|DRUG: Mannose-6-Phosphate (Juvidex)|DRUG: Mannose-6-Phosphate (Juvidex)|DRUG: Mannose-6-Phophate (Juvidex)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the PK, Safety, and Tolerability of Sotrovimab vs Placebo Administered IV or IM in Japanese and Caucasian Participants
Status: COMPLETED
Conditions: Covid19
Interventions: BIOLOGICAL: sotrovimab|OTHER: Placebo to Biologic|BIOLOGICAL: sotrovimab|OTHER: Placebo to Biologic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Therapeutic Exercises and Educational Sessions After Microdiscectomy for Disc Herniation
Status: COMPLETED
Conditions: Minimally Invasive Surgical Procedures|Disk, Herniated
Interventions: OTHER: Patient Education Session|OTHER: Therapeutic Exercise plus educational session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Ampakine Added to Clozapine, Olanzapine or Risperidone in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: CX516 (Ampakine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pegs for Osteofixation of Proximal Humeral Fractures
Status: COMPLETED
Conditions: Implant Complication|Proximal Humeral Fracture|Avascular Necrosis of Humerus
Interventions: DEVICE: Open reduction internal fixation (ORIF) with an angular stable plate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy, Feasibility, and Acceptability of the DeST-ACT: Trauma-Focused Acceptance and Commitment Therapy Program
Status: NOT_YET_RECRUITING
Conditions: Trauma and Stressor Related Disorders
Interventions: BEHAVIORAL: The DeST-ACT Trauma-Focused Acceptance and Commitment Therapy Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Family Engagement, Cross-System Linkage to Substance Use Treatment for Juvenile Probationers -- Phase 3
Status: COMPLETED
Conditions: Substance Use|Substance Abuse|Substance Use Disorders|Substance-Related Disorders|Substance Dependence|Substance Related Problem
Interventions: BEHAVIORAL: Family CONNECT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Adalimumab to Treat Sarcoidosis of the Skin
Status: COMPLETED
Conditions: Sarcoidosis
Interventions: DRUG: adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Absorption, Metabolism, Excretion, and the Determination of Absolute Bioavailability of Niraparib in Subjects With Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Niraparib Oral Capsules (Labeled)|DRUG: Niraparib IV (Labeled)|DRUG: Niraparib Oral Capsules (Unlabeled)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PrEP Optimization Among Women to Enhance Retention and Uptake
Status: RECRUITING
Conditions: PrEP Uptake
Interventions: BEHAVIORAL: PrEP Education|BEHAVIORAL: Provider training|OTHER: EMR Optimization|OTHER: PrEP Navigation|OTHER: Provider Audit and Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of IGIV-C in Symptomatic Subjects With Generalized Myasthenia Gravis
Status: COMPLETED
Conditions: Myasthenia Gravis, Generalized
Interventions: DRUG: IGIV-C|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Microneedling and Topical Pentoxifylline Vesrus Intalesional Pentoxifylline in Treatment of Alopecia Areata: Intra-indiviual Comparative Study
Status: UNKNOWN
Conditions: Alopecia Areata
Interventions: DRUG: Pentoxifylline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FT536 Monotherapy and in Combination With Monoclonal Antibodies in Advanced Solid Tumors
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer|Colorectal Cancer|Breast Cancer|Ovarian Cancer|Pancreatic Cancer|Head and Neck Cancer|GastroEsophageal Cancer
Interventions: DRUG: FT536|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: IL-2|COMBINATION_PRODUCT: Avelumab|COMBINATION_PRODUCT: Pembrolizumab|COMBINATION_PRODUCT: Nivolumab|COMBINATION_PRODUCT: Atezolizumab|COMBINATION_PRODUCT: Trastuzumab|COMBINATION_PRODUCT: Cetuximab|COMBINATION_PRODUCT: Amivantamab|DRUG: IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Brain AVMs (TOBAS) Study
Status: RECRUITING
Conditions: Unruptured Brain Arteriovenous Malformation|Ruptured Brain Arteriovenous Malformation|Arteriovenous Malformations|AVM|BAVM
Interventions: PROCEDURE: Neurosurgery|RADIATION: Radiation therapy|PROCEDURE: Embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dosimetric Planning Study Comparing Intensity Modulated Radiotherapy (IMRT) and 4-field Radiotherapy for Definitive Treatment of Cancer of the Cervix
Status: COMPLETED
Conditions: Cervix Cancer
Interventions: RADIATION: IMRT planning|RADIATION: 4-Field Radiation Planning
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess the Safety and Efficacy of SP-002 With Vismodegib for the Treatment of Locally Advanced Basal Cell Carcinoma
Status: RECRUITING
Conditions: Basal Cell Carcinoma
Interventions: DRUG: SP-002|DRUG: Vismodegib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Potassium-titanyl Phosphate (KTP) Laser vs KTP Laser and Ivermectin Cream for Facial Rosacea
Status: ACTIVE_NOT_RECRUITING
Conditions: Rosacea
Interventions: DEVICE: KTP laser|DRUG: Ivermectin 1% cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First-in-human Study of BAY2287411 Injection, a Thorium-227 Labeled Antibody-chelator Conjugate, in Patients With Tumors Known to Express Mesothelin
Status: COMPLETED
Conditions: Advanced Recurrent Malignant Pleural Epithelioid Mesothelioma|Advanced Recurrent Malignant Peritoneal Epithelioid Mesothelioma|Advanced Recurrent Serous Ovarian Cancer|Advanced Pancreatic Ductal Adenocarcinoma (Optional, Dose Expansion, Not Initiated)
Interventions: DRUG: BAY2287411|DRUG: BAY2287411
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Community-Driven Cervical Cancer Prevention in Western Kenya
Status: COMPLETED
Conditions: Human Papilloma Virus Infection|Carcinoma in Situ of Uterine Cervix
Interventions: BEHAVIORAL: Community-based testing with standard linkage to care|BEHAVIORAL: Community-based HPV testing with enhanced linkage to care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Trial of YY1201 for Treatment of Osteoarthritis of the Knee
Status: WITHDRAWN
Conditions: Osteoarthritis, Knee
Interventions: DRUG: YY1201 2ml|DRUG: Placebo 2ml|DRUG: YY1201 3ml|DRUG: Placebo 3ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Status: RECRUITING
Conditions: Pain, Postoperative|Pain, Chronic|Pain, Acute|Surgical Injury|Surgical Wound|Cornea Injury|Cornea|Keratoconus
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Costs, Cognitive Abilities and Quality of Life After Transcatheter Aortic Valve Implantation and Surgical Aortic Valve Replacement
Status: COMPLETED
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: transcatheter aortic valve implantation|PROCEDURE: Aortic Valve Replacement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigate the Safety Tolerability and Pharmacokinetics of Multiple Doses of AZD1236
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: AZD1236|DRUG: Placebo|DRUG: AZD1236|DRUG: AZD1236
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Choose2Quit: Improving Equity in Smoking Cessation for Low Income Adults
Status: NOT_YET_RECRUITING
Conditions: Tobacco Use
Interventions: OTHER: Referral to Quitline|OTHER: Choose2Quit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Safety, Tolerability and Pharmacokinetic Study of RAY1225
Status: COMPLETED
Conditions: Obese|Healthy
Interventions: DRUG: RAY1225|DRUG: Placebo|DRUG: RAY1225|DRUG: Placebo|DRUG: RAY1225|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Efficacy and Safety of MNK-1411 in Duchenne Muscular Dystrophy
Status: TERMINATED
Conditions: Muscular Dystrophy, Duchenne
Interventions: DRUG: MNK-1411|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Real-time Adaptation to Changes in Insulin Sensitivity
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: The Fading Memory Proportional Derivative/Adaptive Proportional Derivative Algorithm|DEVICE: The Adaptive Proportional Derivative Algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: INSTI's For The Management of HIV-associated TB
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV/AIDS|Tuberculosis, Pulmonary
Interventions: COMBINATION_PRODUCT: Biktarvy®|COMBINATION_PRODUCT: TLD- fixed-drug combination single tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nurses' Health Study (Cardiovascular Component)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases|Diabetes Mellitus|Coronary Disease|Heart Diseases|Cerebrovascular Accident|Pulmonary Embolism|Angina Pectoris|Myocardial Infarction|Menopause|Postmenopause
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Multicomponent Clinic-based Intervention to Promote COVID-19 Vaccine Intention and Uptake Among Diverse Youth and Adolescents
Status: RECRUITING
Conditions: COVID-19 Vaccination
Interventions: BEHAVIORAL: CONFIDENCE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: STYLE -- A Trial of Cell Enriched Adipose For Androgenetic Alopecia
Status: COMPLETED
Conditions: Alopecia, Androgenetic
Interventions: DEVICE: Puregraft System|DEVICE: Celution System|PROCEDURE: Kerastem Therapy|PROCEDURE: Liposuction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: KP415 Classroom Study in Children (6-12 Years of Age) With ADHD
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: KP415 oral capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of CBP-201 in Adult Subjects With Moderate to Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Moderate-to-severe Atopic Dermatitis
Interventions: DRUG: CBP-201|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of YL202 in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer and Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer|Breast Cancer
Interventions: DRUG: YL202
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-blind, Placebo-controlled Trial of the Efficacy and Safety of Tianeptine in the Treatment of Covid Fog Symptoms in Patients After COVID-19.
Status: RECRUITING
Conditions: Nervous System Diseases
Interventions: DRUG: Tianeptine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Growth, Safety and Efficacy of a Probiotic Supplement
Status: COMPLETED
Conditions: Probiotic Supplement
Interventions: OTHER: High dose probiotic supplement|OTHER: Low dose probiotic supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Reverse Transcriptase Inhibitors in AGS
Status: COMPLETED
Conditions: Aicardi-Goutières Syndrome (AGS)
Interventions: DRUG: Reverse transcriptase inhibitors: Zidovudine, Lamivudine, Abacavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Advanced Glycation End Products Are Associated With Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema|Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Dietary habits and intake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Bioequivalence Study of Klaribact 125mg/5ml, Suspension
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Klaribact 125mg/5ml Suspension|DRUG: Klaricid 125mg/5ml Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study Evaluating The Efficacy And Safety Of SBI-087 In Seropositive Subjects With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Active Rheumatoid Arthritis
Interventions: DRUG: SBI-087|DRUG: SBI-087|DRUG: SBI-087|DRUG: SBI-087|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of a Multifaceted Intervention of Environment Control in the ICU to Optimize Quantity and Quality of Sleep
Status: RECRUITING
Conditions: Sleep Disturbance
Interventions: BEHAVIORAL: Multifaceted Intervention of environment control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Alemtuzumab on Microglial Activation Positron Emission Tomography (PET) in Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: DRUG: [F-18]PBR06
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase 1 Study of Iobenguane (MIBG) I 131 in Patients With Malignant Pheochromocytoma/Paraganglioma
Status: COMPLETED
Conditions: Pheochromocytoma|Paraganglioma
Interventions: DRUG: Ultratrace Iobenguane (MIBG) I 131
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Stroke by Left Atrial Appendage Closure in Atrial Fibrillation Patients After Intracerebral Hemorrhage
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation|Stroke|Intracerebral Hemorrhage
Interventions: DEVICE: LAAO|DRUG: Medical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II PAP Plus GM-CSF Versus GM-CSF Alone for Non-metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: pTVG-HP|BIOLOGICAL: rhGM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of Brolucizumab 6mg Compared to Aflibercept 2 mg in a Treat-to-control Regimen (TALON)
Status: COMPLETED
Conditions: Age-related Macular Degeneration
Interventions: BIOLOGICAL: Brolucizumab 6 mg|BIOLOGICAL: Aflibercept 2 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of TDF/FTC + Raltegravir Versus TDF/FTC + Efavirenz in HIV-1-Infected Women
Status: WITHDRAWN
Conditions: HIV-1 Infections
Interventions: DRUG: TDF/FTC Once-Daily + Raltegravir 400 mg Orally Twice-Daily|DRUG: TDF/FTC + Efavirenz (Atripla) Once-Daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Swaddle Blanket on Gastroesophageal Reflux
Status: UNKNOWN
Conditions: Gastroesophageal Reflux|Apnea|Bradycardia|Oxygen Desaturations
Interventions: OTHER: Swaddle Blanket
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia Treatment of Patients With Bipolar Depression
Status: RECRUITING
Conditions: Anhedonia
Interventions: DEVICE: active tDCS|DEVICE: sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction Study of VCH-222 and Telaprevir in Healthy Subjects
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: VCH-222|DRUG: VCH-222|DRUG: VCH-222|DRUG: telaprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Spinal Anesthesia Related Hypotension in SARS-CoV-2 (COVID-19) Pregnant Patients
Status: COMPLETED
Conditions: Hypotension|Regional Anesthesia Morbidity|SARS-CoV2 Infection
Interventions: PROCEDURE: spinal anesthesia induced hypotension in SARS-CoV-2 patients.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the Response and Cardiorespiratory Endurance in Early RA Patients Treated With Tocilizumab or Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tocilizumab|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Surgery With or Without Chemotherapy in Treating Patients With Stage I Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Lung|Adenosquamous Cell Lung Cancer|Bronchoalveolar Cell Lung Cancer|Large Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IB Non-small Cell Lung Cancer
Interventions: DRUG: paclitaxel|DRUG: carboplatin|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects Of Music In Endoscopic Retrograde Cholangiopancreatography Procedure
Status: COMPLETED
Conditions: Endoscopic Retrograde Cholangio-Pancreatography|Anxiety|Pain
Interventions: OTHER: Music listening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Microwave Ablation vs Radiofrequency Ablation in the Management of Complicated Monochorionic Pregnancies：A RCT Study
Status: UNKNOWN
Conditions: Twin; Complicating Pregnancy|Microwave Ablation
Interventions: PROCEDURE: Microwave ablation|PROCEDURE: Radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colon Cleansing Quality of Polyethylene Glycol Compared With Polyethylene Glycol Plus Ascorbic Acid.
Status: COMPLETED
Conditions: Colonoscopy Preparation
Interventions: DRUG: Polyethylene glycol 4000|DRUG: Macrogol 3350 plus ascorbic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Superficial Dry Needling Versus Deep Dry Needling on the Upper Trapezius
Status: COMPLETED
Conditions: Neck Pain
Interventions: PROCEDURE: Experimental: Deep dry needling|PROCEDURE: Experimental: Superficial dry needling|PROCEDURE: Placebo Comparator: Placebo Gastrocnemius dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rechallenge of Imatinib in GIST Having no Effective Treatment: RIGHT
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumors
Interventions: DRUG: Imatinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness Meditation Neuroimaging Study for Undergraduates
Status: COMPLETED
Conditions: Inflammation|Psychosocial Functioning|Depression, Anxiety
Interventions: BEHAVIORAL: Mindfulness Meditation classes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of Endogenous Oxalate Synthesis
Status: RECRUITING
Conditions: Healthy|Kidney Stone|Obesity
Interventions: DIETARY_SUPPLEMENT: Low-oxalate controlled diet|OTHER: Primed, continuous intravenous infusion of 13C2-oxalate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: AMG 176 With Azacitidine in Subjects With Myelodysplastic Syndrome /Chronic Myelomonocytic Leukemia
Status: COMPLETED
Conditions: Higher Risk Myelodysplastic Syndrome|Chronic Myelomonocytic Leukemia
Interventions: DRUG: AMG 176|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Older Adults With Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Prednisone|DRUG: Vincristine|DRUG: Doxorubicin|DRUG: PEG-asparaginase|DRUG: Cytarabine|DRUG: Methotrexate|DRUG: Imatinib|DRUG: Clofarabine|DRUG: 6 Mercaptopurine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reversal of General Anesthesia With Methylphenidate
Status: COMPLETED
Conditions: Post Operative Cognitive Dysfunction|Emergence From Anesthesia
Interventions: DRUG: Methylphenidate|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Exploiting the Potential of Neural Attentional Control to Overcome Hearing Impairment
Status: RECRUITING
Conditions: Hearing Loss|Attention Impaired|Tinnitus
Interventions: DEVICE: tACS - transcranial alternating current stimulation|DEVICE: sham - transcranial alternating current stimulation|DEVICE: NF - Neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Letrozole Versus Chinese Herbal Medicine on Polycystic Ovary Syndrome (PCOS)
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Letrozole|DRUG: Chinese herbal medicine granules or Chinese herbal medicine granules placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Of Bacterial Lysate In Children With Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Ismigen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CAE for Poorly Adherent Individuals With Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Customized Adherence Enhancement for Schizophrenia (CAE-S)|OTHER: Enhanced Treatment as Usual (eTAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of TU7710 in Warfarin Anti-coagulated Healthy Male Subjects
Status: RECRUITING
Conditions: Hemophilia A|Hemophilia B|Blood Coagulation Disorders
Interventions: DRUG: TU7710|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bipolar Electrosurgery Versus Thermocautery in Circumcision With Safe Anesthetic Techniques
Status: COMPLETED
Conditions: Circumcision
Interventions: DEVICE: Bipolar Electrosurgery|DEVICE: Thermocautery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Anesthesia Standard Operating Procedure During On-pump Coronary Artery Bypass Grafting
Status: UNKNOWN
Conditions: Coronary Artery Disease|Low Cardiac Output Syndrome|Atrial Fibrillation|Postoperative Complications
Interventions: DRUG: Low opioid anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weekly Docetaxel and Four Weekly Carboplatin in Non-small Cell Lung Cancer Carbo-Tax
Status: COMPLETED
Conditions: Lung Neoplasms
Interventions: DRUG: docetaxel and carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug-Drug Interaction Study of Losartan and PA21
Status: COMPLETED
Conditions: Drug Interaction Potentiation
Interventions: DRUG: PA21 and Losartan with Food|DRUG: No PA21; Losartan with food|DRUG: PA21 with food and Losartan 2 hours later
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Abiraterone Acetate in Patients With Relapsed and/or Metastatic Salivary Gland Cancers
Status: COMPLETED
Conditions: Salivary Glands Tumors
Interventions: DRUG: Abiraterone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Extragonadal Germ Cell Tumor|Ovarian Cancer|Teratoma|Testicular Germ Cell Tumor
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: ifosfamide|DRUG: paclitaxel|PROCEDURE: autologous hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of K201 Injection on Restoration of Sinus Rhythm in Subjects Who Are in Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: K201 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-Interventional Study (NIS) of Nivolumab With or Without Ipilimumab in Participants With Advanced Kidney Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma|Renal Cell Cancer|Adenocarcinoma Of Kidney|Adenocarcinoma, Renal Cell|Kidney Cancer|Cancer of the Kidney
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study to Assess the Effect of a Probiotic Blend on Moderate Self-reported Anxiety.
Status: COMPLETED
Conditions: Anxiety
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MRD-Guided Consolidation Therapy Following Definitive Radiotherapy in Esophageal Cancer
Status: RECRUITING
Conditions: Esophageal Cancer
Interventions: DRUG: PD-1 monoclonal antibody consolidation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of NK012 and Carboplatin in Solid Tumors With Dose Expansion in Triple Negative Breast Cancer
Status: COMPLETED
Conditions: Advanced Solid Tumors|Metastatic Triple Negative Breast Cancer
Interventions: DRUG: NK012 and carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Unilateral Neck Irradiation in Patients With SCC of the Head and Neck
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: RADIATION: Radiation therapy|RADIATION: definitive external beam radiation in the ipsilateral neck
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fasting Study of Zonisamide Capsules 100 mg and Zonegran® Capsules 100 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Zonisamide Capsules 100 mg|DRUG: Zonegran® Capsules 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) Study of G-Pen(TM) (Glucagon Injection) to Treat Severe Hypoglycemia
Status: COMPLETED
Conditions: Hypoglycemia
Interventions: DRUG: G-Pen(TM) 1 mg|DRUG: Lilly Glucagon(TM) 1 mg|DRUG: G-Pen(TM) 0.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Effects of DVS SR and Duloxetine on the Pharmacokinetics of Desipramine in Healthy Subjects
Status: COMPLETED
Conditions: Depression|Depressive Disorder|Depressive Disorder, Major
Interventions: DRUG: desvenlafaxine SR|DRUG: desipramine|DRUG: duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Radiation Therapy for HE2-positive Oligometastatic Breast Cancer
Status: RECRUITING
Conditions: HER2-positive Metastatic Breast Cancer|Oligometastatic Disease
Interventions: DRUG: Trastuzumab emtansine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of PGDM1400LS Alone and in Combination With VRC07-523LS and PGT121.414.LS in Healthy, HIV-uninfected Adult Participants
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: PGDM1400LS (5mg/kg, IV)|DRUG: PGDM1400LS (20mg/kg, IV)|DRUG: PGDM1400LS (20mg/kg, SC)|DRUG: PGDM1400LS (40mg/kg, IV)|DRUG: PGDM1400LS (40mg/kg, SC)|DRUG: PGDM1400LS (1.4g, IV)|DRUG: PGDM1400LS (1.4g, SC)|DRUG: VRC07-523LS (20mg/kg, IV)|DRUG: VRC07-523LS (20mg/kg, SC)|DRUG: VRC07-523LS (1.4g, IV)|DRUG: VRC07-523LS (1.4g, SC)|DRUG: VRC07-523LS (40mg/kg, IV)|DRUG: PGT121.414.LS (20mg/kg, IV)|DRUG: PGT121.414.LS (20mg/kg, SC)|DRUG: PGT121.414.LS (1.4g, IV)|DRUG: PGT121.414.LS (1.4g, SC)|DRUG: PGT121.414.LS (40mg/kg, IV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 2 Study of RTA 901 (BIIB143) in Participants With Diabetic Peripheral Neuropathic Pain (CYPRESS)
Status: RECRUITING
Conditions: Diabetic Peripheral Neuropathic Pain
Interventions: DRUG: RTA 901|DRUG: RTA 901-Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Effects of Sheffield Support Snood in MND Patients
Status: COMPLETED
Conditions: Motor Neurone Disease
Interventions: BEHAVIORAL: Head movements|BEHAVIORAL: Activities of daily living (drinking, washing hand and eating)|DEVICE: Sheffield Support Snood|DEVICE: sEMG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...
Status: RECRUITING
Conditions: Neurofibroma, Plexiform|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Leukemia, Promyelocytic, Acute|Sarcoma
Interventions: DRUG: TURALIO(R)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Unilateral, Bilateral and Combined Resistance Training on the Speed and Accuracy of the Serve in Youth Tennis Players
Status: ENROLLING_BY_INVITATION
Conditions: Exercise Training
Interventions: OTHER: Unilateral resistance training programme|OTHER: Bilateral resistance training programme|OTHER: Combined（UL+BL） resistance training programme
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficiency Study of Mesenchymal Stem Cell (19#iSCLife®-POI) in Premature Ovarian Insufficiency
Status: SUSPENDED
Conditions: Premature Ovarian Failure
Interventions: BIOLOGICAL: hucMSCs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ambrisentan for the Improvement in Right Ventricular Strain in Scleroderma Associated Pulmonary Arterial Hypertension
Status: TERMINATED
Conditions: Pre-Pulmonary Atrial Hypertension
Interventions: DRUG: Ambrisentan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Split-course Hypofractionated Radiotherapy With Concurrent Chemotherapy in Locally Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: RADIATION: split-course radiotherapy|DRUG: concurrent chemotherapy|DRUG: consolidation immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Oral Acyclovir Usage to Prevent Herpes Zoster Virus Infection After Bone Marrow Transplant
Status: COMPLETED
Conditions: VZV Infection After Bone Marrow Transplantation
Interventions: DRUG: Acyclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: INDV-2000 First in Human
Status: COMPLETED
Conditions: Opioid Dependence
Interventions: DRUG: INDV-2000|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT