pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Combined Effect of Acitretin and Narrow Band Ultraviolet B on Vitiligo Repigmentation
Status: UNKNOWN
Conditions: Hyperlipidemias|Xerosis|Depression|Liver Diseases
Interventions: DRUG: Acitretin|OTHER: Narrow band ultraviolet B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is Regional Anesthesia of the Hip Preferable Over Traditional Analgesia in the Acute Stage of the Management of Patients With a Fracture of the Hip
Status: TERMINATED
Conditions: Hip Fractures
Interventions: DRUG: Ropivacaine|DRUG: Natrium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Plant Sterols and Plant Stanols and Liver Inflammation
Status: UNKNOWN
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: DIETARY_SUPPLEMENT: Plant sterol-enriched margarine|DIETARY_SUPPLEMENT: Plant stanol-enriched margarine|DIETARY_SUPPLEMENT: Control margarine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin K2 Effect on Vascular Stiffening in Subjects With a Poor Vitamin K-status
Status: UNKNOWN
Conditions: Vascular Stiffness
Interventions: DIETARY_SUPPLEMENT: Menaquinone-7|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Tolerance Evaluation in FOLFIRINOX Dose Adjusted in Elderly Patients With a Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Metastatic Cancer|Toxicity
Interventions: DRUG: Oxaliplatine|DRUG: Folinic acid|DRUG: Irinotecan|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance-Guided Hypofractionated Adaptive Radiation Therapy With Concurrent Chemotherapy and Consolidation Durvalumab for Inoperable Stage IIB, IIIA, and Select IIIB and IIIC Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage IIB Non-Small Cell Lung Cancer|Stage IIIA Non-small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer|Stage IIIC Non-Small Cell Lung Cancer
Interventions: DEVICE: ViewRay MR-Linear Accelerator|RADIATION: Radiation therapy|DRUG: Paclitaxel|DRUG: Carboplatin AUC|BIOLOGICAL: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nimotuzumab Combined With Radiotherapy in High-risk Patients With HNSCC Not Suitable for Cisplatin After Surgery
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Nimotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of CD70-targeted CAR-T Therapy for Advanced/Advanced Renal Cancer
Status: RECRUITING
Conditions: Metastatic Tumor|Renal Cell Carcinoma|Advanced Cancer
Interventions: BIOLOGICAL: CD70 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumabe or Triamcinolone for Persistent Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Bevacizumab Injection [Avastin] (IVB-I)|DRUG: Triamcinolone Acetonide 10mg/mL (IVT-II)|DRUG: Bevacizumab Injection [Avastin] (IVB-III)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 24-Week Study to Assess the PD, Safety, Tolerability, and PK of GLM101 in Participants With PMM2-CDG
Status: RECRUITING
Conditions: Pmm2-CDG
Interventions: DRUG: GLM101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PriMatrix for the Management of Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: PriMatrix Dermal Repair Scaffold|DEVICE: Secondary Dressings|DEVICE: Offloading device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1, Multiple Ascending Dose Study of Anti-HER2 FCAB FS102 in HER2 Positive Solid Tumors (Anti HER2 Fcab)
Status: COMPLETED
Conditions: Solid Tumors That Overexpress HER2 (HER2 Positive)
Interventions: DRUG: FS102
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture Combined With Mirabegron in the Treatment of OAB
Status: ACTIVE_NOT_RECRUITING
Conditions: Overactive Bladder
Interventions: DRUG: 50 mg of mirabegron|COMBINATION_PRODUCT: acupuncture combined with mirabegron.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Atypical Antipsychotic Agents in Augmenting SSRI-Refractory Obsessive-Compulsive Disorder
Status: COMPLETED
Conditions: SSRI-Refractory Obsessive-Compulsive Disorder
Interventions: DRUG: atypical antipsychotic drug|BEHAVIORAL: exposure response prevention
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: A Randomized Comparison of Intraoperative Warming With the LMA PerfecTemp and Forced-air
Status: COMPLETED
Conditions: Warming Systems During Surgery
Interventions: DEVICE: heated blanket|DEVICE: heated pad
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing Efficacy and Safety of CinnaGen-liraglutide Versus Victoza® in Patients With Type II Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Liraglutide 6 MG/ML Pen Injector|DRUG: Metformin|DRUG: Sulfonylurea/non-sulfonylurea insulin secretagogues
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide, Antithymocyte Globulin, and Total-Body Irradiation in Treating Patients With Severe Aplastic Anemia Undergoing Umbilical Cord Blood Transplant
Status: TERMINATED
Conditions: Aplastic Anemia
Interventions: RADIATION: total-body irradiation|DRUG: cyclophosphamide|BIOLOGICAL: anti-thymocyte globulin|DRUG: cyclosporine|PROCEDURE: umbilical cord blood transplantation|DRUG: mycophenolate mofetil|PROCEDURE: bone marrow aspiration|GENETIC: DNA analysis|BIOLOGICAL: filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Various Combinations of Anti-HIV Medications to Treat Early HIV Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Lamivudine/Zidovudine|DRUG: Ritonavir|DRUG: Hydroxyurea|DRUG: Abacavir sulfate|DRUG: Amprenavir|DRUG: Nelfinavir mesylate|DRUG: Efavirenz|DRUG: Lamivudine|DRUG: Stavudine|DRUG: Zidovudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Smart Home Technologies for Assessing and Monitoring Frailty in Older Adults
Status: COMPLETED
Conditions: Frailty|Frailty Syndrome|Frail Elderly Syndrome|Pre-Frailty|Healthy|Healthy Aging|Aging Problems|Aging Disorder
Interventions: DEVICE: Smart-Home Monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prompt Or Watchful Monitoring for Hepatitis B Virus Related Hepatocellular Carcinoma Without Elevated viRal Load
Status: UNKNOWN
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Tenofovir disoproxil fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Wolbachia Deployment on Arboviral Disease Incidence in Medellin and Bello, Colombia
Status: COMPLETED
Conditions: Dengue|Chikungunya Virus Infection|Zika Virus Infection
Interventions: BIOLOGICAL: Wolbachia-carrying Ae.aegypti mosquitoes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vinblastine and Methotrexate in Treating Children With Desmoid Tumors
Status: COMPLETED
Conditions: Desmoid Tumor
Interventions: DRUG: methotrexate|DRUG: vinblastine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Brief Cognitive and Behavioral Skills Program on Stage Transitions for Chronic Ketamine Abusers
Status: COMPLETED
Conditions: Substance Use Disorders
Interventions: BEHAVIORAL: Cognitive behavioral skills training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Upper Extremity Functional Skills on Quality of Life and Participation of the Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Diplegia|Upper Extremity Dysfunction|Quality of Life|Participation, Patient
Interventions: OTHER: All assessments of children (Demographic information, upper extremity skills, quality of life and participation levels)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tapping Test and the Archimedean Spiral for the Differential Diagnosis of Tremor. Machine Learning Approach
Status: RECRUITING
Conditions: Tremor|Essential Tremor|Parkinson Disease
Interventions: DIAGNOSTIC_TEST: Tapping Test|DIAGNOSTIC_TEST: Archimedes Spiral
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose-finding of PB-119 Administered Subcutaneously Once Weekly Versus Placebo in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus (T2DM)
Interventions: DRUG: PB-119 100 μg+ Glucophage®|DRUG: PB-119 150 μg+ Glucophage®|DRUG: PB-119 200 μg+ Glucophage®|DRUG: PB-119 placebo + Glucophage®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Delanzomib (CEP-18770) in Combination With Lenalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: CEP-18770|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CT-P13 (Infliximab) Subcutaneous Administration in Patients With Moderately to Severely Active Crohn's Disease (LIBERTY-CD)
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: CT-P13 SC (Infliximab)|OTHER: Placebo SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a Latanoprost Ocular Implant for Treatment of Open Angle Glaucoma or Ocular Hypertension.
Status: COMPLETED
Conditions: Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: 100ng/day PA5346 Latanoprost FA SR Ocular Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Phase III Comparison of Superiority, Open With Blind Appraiser, to Evaluate the Efficacy and Safety of Barium Sulphate 66.7% With V (OPTI-BAR) Compared to Proceedings in Inert Radiological Examinations for the Diagnosis of Diseases for Image the Tratogastrointstinal
Status: UNKNOWN
Conditions: X-ray Examinations of the Gastrointestinal Tract
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Supporting At-Risk Mothers Across Perinatal Period
Status: RECRUITING
Conditions: Perinatal Depression|Parents|Anxiety|Self Efficacy|Stress|Infant Development
Interventions: BEHAVIORAL: Supporting at-risk Mothers Across perinatal period: a Randomized controlled Trial (SMART) mobile application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cognitive Control Training as an Adjunct to Behavioral Activation Therapy in the Treatment of Depression
Status: UNKNOWN
Conditions: Depression
Interventions: BEHAVIORAL: Brief Behavioral Activation Treatment for Depression|BEHAVIORAL: Cognitive Control Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dabigatran in an Interaction Probe Drug Cocktail
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Caffeine|DRUG: Diclofenac|DRUG: Esomeprazole|DRUG: Metoprolol|DRUG: Midazolam|DRUG: Dabigatran|DRUG: Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 3 Study Evaluating Safety and Efficacy of OTX-DP for Treatment of Ocular Inflammation and Pain After Cataract Surgery
Status: COMPLETED
Conditions: Post Ocular Surgical Inflammation and Pain
Interventions: DRUG: Dexamethasone|DRUG: Punctum Plug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of H. Pylori Eradication on the Gastric Preneoplastic Lesion and Neoplasm After ESD
Status: ACTIVE_NOT_RECRUITING
Conditions: Helicobacter Pylori Infection|Early Gastric Cancer|Endoscopic Resection
Interventions: DRUG: 7 day H.pylori eradication Omeprazole or Rabeprazole, Clarithromycin, Amoxicillin|DRUG: Placebo, Omeprazole or Rabeprazole, Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SLND or Not in cT1 GGO Invasive Lung Adenocarcinoma (ECTOP-1009)
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: PROCEDURE: Systematically mediastinal lymph node dissection|PROCEDURE: No mediastinal lymph node dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-blind, Active-controlled, Study of Rivoglitazone in Type 2 Diabetes Mellitus
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Rivoglitazone HCl|DRUG: rivoglitazone HCl|DRUG: rivoglitazone HCl|DRUG: placebo|DRUG: pioglitazone HCl|DRUG: pioglitazone HCl|DRUG: pioglitazone HCl 45 mg|DRUG: placebo|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose Study of MHS552 in Adults Participants With Systemic Lupus Erythematosus (SLE)
Status: TERMINATED
Conditions: Lupus Erythematosus, Systemic
Interventions: DRUG: MHS552|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Guided Focused Ultrasound for Uterine Fibroids
Status: COMPLETED
Conditions: Uterine Fibroids
Interventions: PROCEDURE: MR Guided Focused Ultrasound|PROCEDURE: Placebo MR Guided Focused Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endothelial Cell Loss After Phacoemulsification Intra and Supracapsular
Status: COMPLETED
Conditions: Cataracts
Interventions: PROCEDURE: Subluxation|PROCEDURE: Divide and Conquer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Influence of Pantoprazole on the Pharmacokinetics of Fradafiban After Multiple Oral Doses of Lefradafiban in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lefradafiban tablet|DRUG: Pantoprazole tablet|DEVICE: Lefradafiban double chamber sachet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing SUBA™-Itraconazole With SPORANOX® (Itraconazole) in the Treatment of Onychomycosis
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: SUBA-itraconazole|DRUG: Itraconazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Chiropractic Application for Acute Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain, Mechanical
Interventions: DRUG: diclophenac sodium (75 mg, IM) and thiocolchicoside (4 mg, IM)|OTHER: Chiropractic Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CAR-T CD19/CD20 for Patients With Advanced CD19/CD20+ B Cell Line Recurrent or Refractory Hematological Malignancies
Status: UNKNOWN
Conditions: CAR
Interventions: DRUG: CD19/CD20 CAR-T cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Light Therapy in Disorders of Consciousness: Behavioral, Neuroimaging and (Neuro)Physiological Assessments.
Status: UNKNOWN
Conditions: Disorder of Consciousness
Interventions: DEVICE: Light therapy - active|DEVICE: Placebo light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tinengotinib (TT-00420) in Combination With Standard Treatments in People With Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Tinengotinib|DRUG: abiraterone acetate|DRUG: Prednisone or Enzalutamide|DRUG: Tinengotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Post-Transplant Cyclophosphamide as GVHD Prophylaxis to Standard of Care for Acute Leukemia Patients
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia (ALL) in Complete Remission|Acute Myeloid Leukemia (AML) in Remission
Interventions: DRUG: Cyclophosphamide 50mg|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Postpartum Weight Loss for Women at Elevated Cardiovascular Risk
Status: COMPLETED
Conditions: Weight Loss|Postpartum Weight Retention|Hypertension in Pregnancy|Diabetes Mellitus in Pregnancy|Preeclampsia|Recruitment
Interventions: BEHAVIORAL: Online Behavioral Weight Loss Program|BEHAVIORAL: Virtual weigh-in
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Work, Weight, and Wellness Program: The 3W Program
Status: COMPLETED
Conditions: Cardiovascular Diseases|Heart Diseases|Obesity
Interventions: BEHAVIORAL: Exercise and diet|BEHAVIORAL: Diet, Weight Reducing|BEHAVIORAL: Level 1|BEHAVIORAL: Level 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Role of Oral Glutathione on Growth Parameters in Children With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Oral Glutathione|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE)
Status: COMPLETED
Conditions: Heart Diseases|Heart Failure, Congestive|Heart Failure
Interventions: PROCEDURE: catheterization, Swan-Ganz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Atrial Natriuretic Peptide in Assessing Fluid Status
Status: COMPLETED
Conditions: Fluid Overload|Fluid Loss|Volume Overload|Cardiac Disease|Cardiac Output, Low|Cardiac Output, High
Interventions: DIAGNOSTIC_TEST: pro-ANP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Preliminary Evaluation of the Safety and Tolerability of SPOT-mRNA01 Subcutaneously Administered in Healthy Subjects
Status: NOT_YET_RECRUITING
Conditions: Skin Aging
Interventions: BIOLOGICAL: SPOT-mRNA01|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Somatotopic Configuration of Distal Residual Limb Tissues in Lower Extremity Amputations
Status: ACTIVE_NOT_RECRUITING
Conditions: Amputation
Interventions: PROCEDURE: Modified amputation procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Complications and Recurrences After Mohs Micrographic Surgery and Slow Mohs
Status: RECRUITING
Conditions: Skin Cancer|Complication|Complication of Surgical Procedure|Complication,Postoperative|Recurrence|Recurrent Disease|Cutaneous Squamous Cell Carcinoma|Basal Cell Carcinoma|Lentigo Maligna|Lentigo Maligna Melanoma
Interventions: PROCEDURE: Mohs surgery|PROCEDURE: Slow Mohs surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Clinical Trial of the Anti Hepatitis B Placenta Transfer Factor Injection
Status: UNKNOWN
Conditions: HBeAg Positive Chronic Hepatitis B
Interventions: DRUG: Anti-HBV placenta transfer factor injection|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Malezi Na Kilimo Bora - Skilful Parenting and Agribusiness Child Abuse Prevention Study
Status: COMPLETED
Conditions: Child Abuse|Parenting
Interventions: BEHAVIORAL: Skilful Parenting|OTHER: Agrics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Sensor Randomized Controlled Trial: Setting Expectations to Increase Satisfactory Outcomes After Total Knee Replacement
Status: ACTIVE_NOT_RECRUITING
Conditions: Patient Satisfaction
Interventions: OTHER: Patient-Specific Prediction of Functional Outcome|OTHER: Standard Pre-Operative Total Knee Arthroplasty Information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: S-1, Gemcitabine and Erlotinib for Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreas Neoplasms
Interventions: DRUG: GES (Gemcitabine, Erlotinib, S-1)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic and Translational Values of Point-of-care Blood Eosinophils and Exhaled Nitric Oxide (FeNO) in People Referred by Primary Care for Suspected Asthma
Status: RECRUITING
Conditions: Asthma|Asthma in Children|Diagnosis|Inflammation
Interventions: DIAGNOSTIC_TEST: ¸FeNO
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility Study of 68Ga-PSMA PET-CT and 18F-FDOPA PET-CT in Glioblastoma's Patients
Status: UNKNOWN
Conditions: Glioblastomas
Interventions: DIAGNOSTIC_TEST: Feasibility study for the realization of 68Ga-PSMA PET-CT and 18F-FDOPA PET-CT for identification of early recurrence in patients treated with radiotherapy for glioblastoma.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Video-Based Gaming Therapy in Pes Planus Rehabilitation
Status: RECRUITING
Conditions: Serious Game|Videogames|Pes Planus|Virtual Reality|Exergame
Interventions: PROCEDURE: Structured Pes Planus Exercises|PROCEDURE: Wii Based Exergame|PROCEDURE: Wii Based Serious Game
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Levosimendan in CABG Patients With Poor LV Function
Status: COMPLETED
Conditions: Coronary Artery Bypass Grafting|Left Ventricular Dysfonction
Interventions: DRUG: levosimendan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial of Telbivudine Combination Therapy vs. Continued Adefovir Monotherapy
Status: WITHDRAWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: Telbivudine|DRUG: Adefovir|DRUG: Tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Whole Genome Sequencing for Blood Group Genotyping and Definition as Exemplified on U- and St(a)+.
Status: UNKNOWN
Conditions: Genetic Blood Group (bg) Polymorphism in U Negativity and St(a) of MNSs
Interventions: OTHER: Whole Genome Sequencing (WGS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ventilator Associated Pneumonia Care Bundle Prevention on Internship Students' Knowledge and Clinical Performance
Status: COMPLETED
Conditions: Ventilator Associated Pneumonia
Interventions: BEHAVIORAL: Routine PICU nursing care for children on mechanical ventilator.|BEHAVIORAL: Self-instructional module for VAP care bundle prevention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Familial Hypercholesterolemia Interpretive Comment - Nudging to Detection.
Status: NOT_YET_RECRUITING
Conditions: Familial Hypercholesterolemia
Interventions: OTHER: Biochemistry interpretive comment on elevated LDL-C levels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: In Person and Mobile Health Coping Skills Training for Improving Symptom Management and Daily Steps in Hematopoietic Stem Cell Transplant Patients
Status: COMPLETED
Conditions: Hematopoietic Neoplasms (Leukemia, Lymphoma, Multiple Myeloma)
Interventions: BEHAVIORAL: coping skills training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Attention Deficit/Hyperactivity Disorder and Substance Use Disorder on Motorcycle Traffic Accidents
Status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Methylphenidate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: MOrphometric MRI Analysis of Cortical Sulci: Development of NEurodevelopmental Biomarkers of Bipolar Disorder.
Status: NOT_YET_RECRUITING
Conditions: Bipolar Disorder
Interventions: OTHER: MRI exam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Inhibition of Aldosterone to Reduce Myocardial Diffuse Fibrosis in Patients With Paroxysmal and Persistent Atrial Fibrillation in Preventing Recurrent Episodes of Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DRUG: Spironolactone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Breast Cancer With Trastuzumab + HS627/ Pertuzumab + Docetaxel
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: HS627|DRUG: Pertuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bremelanotide in Premenopausal Women With Female Sexual Arousal Disorder and/or Hypoactive Sexual Desire Disorder
Status: COMPLETED
Conditions: Female Sexual Arousal Disorder|Hypoactive Sexual Desire Disorder
Interventions: DRUG: bremelanotide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Impact of Using Wearable Devices in Addition to Standard Clinical Practice on Parkinson´s Subject Symptoms Management
Status: COMPLETED
Conditions: Parkinson´s Disease
Interventions: DEVICE: Kinesia-ONE™|DEVICE: Kinesia-360™|DRUG: Rotigotine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Irinotecan Plus 5-FU / LV Combined With Paricalcitol in Patients With Advanced Pancreatic Cancer Progressed on Gemcitabine-based Therapy
Status: COMPLETED
Conditions: Pancreatic Cancer|Pancreas Cancer|Cancer of the Pancreas
Interventions: DRUG: 5-FU|DRUG: Leucovorin|DRUG: Liposomal Irinotecan|DRUG: Paricalcitol|PROCEDURE: Serum and plasma blood samples|PROCEDURE: Tumor biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pediatric Eosinophilic Esophagitis (pedEoE): Effect of Allergen Heat Denaturation on EoE Remission: a Pilot Trial
Status: RECRUITING
Conditions: Eosinophilic Esophagitis
Interventions: OTHER: Implementation of cow's milk in decreasingly heated forms|OTHER: Implementation of hen's egg in decreasingly heated forms
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Examine the Efficacy and Safety of Movicol in the Treatment of Chronic Constipation in Children
Status: COMPLETED
Conditions: Chronic Constipation
Interventions: DRUG: Polyethylene glycol 3350 Na bicarbonate NaCl KCl (Movicol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: PET Scans in Patients With Diffuse Large B-Cell Lymphoma Receiving Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: prednisone|DRUG: vincristine sulfate|PROCEDURE: positron emission tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effects of Low-dose S-ketamine in Major Spine Fusion Surgery
Status: RECRUITING
Conditions: S-ketamine|Postoperative Analgesia|Spine Fusion
Interventions: DRUG: S-ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)
Status: RECRUITING
Conditions: X-linked Severe Combined Immunodeficiency (XSCID)
Interventions: BIOLOGICAL: Ex vivo culture and transduction of the patient's autologous CD34+ HSC with lentivirus vector VSV-G pseudotyped CL20- 4i-EF1alpha-hgammac-OPT vector|DRUG: Busulfan|DRUG: Palifermin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety of Compressive Socks to Treat Venous Insufficiency in Patients With Peripheral Arterial Disease
Status: COMPLETED
Conditions: Peripheral Arterial Disease|Venous Insufficiency
Interventions: DEVICE: contention socks
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of the Safety and Efficacy of STI-6643 in Subjects With Advanced Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor|Relapsed Solid Neoplasm|Refractory Tumor
Interventions: BIOLOGICAL: STI-6643
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antiresorptive Effect of Treatment With Risedronate and Vitamin D in Postmenopausal Patients
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis|Hypovitaminosis D|Hyperparathyroidism
Interventions: DRUG: Risedronate|DRUG: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Manta™ Versus Suture-based Closure After Transcatheter Aortic Valve Implantation Trial
Status: COMPLETED
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: MANTA vascular closure device|DEVICE: Suture based vascular closure device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Analgesia on Postoperative Opioid Usage and Pain Control in H&N Cancer Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Postoperative Pain Control|Opioid Consumption
Interventions: DRUG: Ketamine|DRUG: Placebo Ketamine|DRUG: Lidocaine|DRUG: Placebo Lidocaine|DRUG: Acetaminophen|DRUG: Placebo Acetaminophen|DRUG: Gabapentin|DRUG: Placebo Gabapentin|DRUG: Celecoxib|DRUG: Placebo Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Metabolic and Cardiovascular Effects of Dipeptidyl Peptidase-4 (DPP-4) or Sodium-glucose Co-transporter Type 2 (SGLT2) Inhibitors
Status: UNKNOWN
Conditions: Effects of the DPP-4 Inhibitors or SGLT2 Inhibitors on the Protective Actions for Diabetic Complications
Interventions: DRUG: DPP-4 inhibiotors|DRUG: SGLT2 inhibitors|DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Parallel Group Study to Compare the Gastroprotective Effects of PA 325 Versus 81 mg Enteric Coated Aspirin
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: aspirin|DRUG: omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two-Lumen Catheterization For Lung Wedge Resection
Status: UNKNOWN
Conditions: Thoracic Surgery, Video-Assisted
Interventions: PROCEDURE: chest tube|PROCEDURE: two-lumen catheterization|DEVICE: two-lumen catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Electronic Written Communication in Aphasia
Status: COMPLETED
Conditions: Aphasia
Interventions: BEHAVIORAL: Texting Intervention (T-WRITE)|BEHAVIORAL: HandWriting Intervention (ORLA+WTG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nab-paclitaxel and S-1 in Patients With Locally Advanced Pancreatic Cancer
Status: UNKNOWN
Conditions: Locally Advanced Pancreatic Cancer
Interventions: DRUG: Nab-paclitaxel and S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Three Different Cardiopulmonary Resuscitation (CPR) Training Methods
Status: COMPLETED
Conditions: Cardiopulmonary Resuscitation
Interventions: PROCEDURE: Feedback During CPR Training and Testing|PROCEDURE: No Feedback Group|PROCEDURE: Feedback during CPR Training Not Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intervention on Caregivers Caring for Patients Poststroke With Upper Limb Apraxia
Status: COMPLETED
Conditions: Performance Anxiety|Emotional Stress
Interventions: OTHER: Program on specific prevention of health|OTHER: Program on general prevention of health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immune Checkpoint Inhibitors With or Without Propranolol Hydrochloride In Patients With Urothelial Carcinoma
Status: RECRUITING
Conditions: Locally Advanced Bladder Urothelial Carcinoma|Locally Advanced Renal Pelvis Urothelial Carcinoma|Locally Advanced Ureter Urothelial Carcinoma|Locally Advanced Urethral Urothelial Carcinoma|Locally Advanced Urothelial Carcinoma|Metastatic Bladder Urothelial Carcinoma|Metastatic Renal Pelvis Urothelial Carcinoma|Metastatic Ureter Urothelial Carcinoma|Metastatic Urethral Urothelial Carcinoma|Metastatic Urothelial Carcinoma|Stage IV Bladder Cancer AJCC v8|Stage IV Renal Pelvis Cancer AJCC v8|Stage IV Ureter Cancer AJCC v8|Stage IV Urethral Cancer AJCC v8
Interventions: DRUG: Pembrolizumab|DRUG: Propranolol Hydrochloride|DRUG: Nivolumab|DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of and Immune Response to an HIV Vaccine (SF-2 gp120) With or Without MTP-PE/MF59 Adjuvant
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: rgp120/HIV-1 SF-2|BIOLOGICAL: MTP-PE/MF59
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Studying DNA and Outcome in Patients With Advanced Colorectal Cancer Treated With Fluorouracil and Oxaliplatin With or Without Bevacizumab on Clinial Trial E-3200
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: GENETIC: DNA methylation analysis|GENETIC: loss of heterozygosity analysis|GENETIC: microsatellite instability analysis|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Adolescent Surgery Experience: A Mixed Methods Analysis
Status: COMPLETED
Conditions: Pain, Postoperative|Pain|Pain, Acute|Pain, Chronic|Adolescent Behavior|Opioid Use
Interventions: BEHAVIORAL: Baseline Survey|BEHAVIORAL: Post Operative Surveys|BEHAVIORAL: Qualitative Interviews
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pembrolizumab Plus Lenvatinib for First-line Advanced/Metastatic Non-clear Cell Renal Cell Carcinoma (1L nccRCC) (MK-3475-B61)
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Milk-induced Gastrointestinal Symptoms in Infants
Status: COMPLETED
Conditions: Gastrointestinal Symptoms in Young Infants
Interventions: DIETARY_SUPPLEMENT: Formula milk free of cow's milk protein|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessments of Dynamic Variables of Fluid Responsiveness to Predict Desufflation-induced Hypotension in Urologic Patients Undergoing Laparoscopic Surgery
Status: UNKNOWN
Conditions: Deflation Induced Hypotension|Laparoscopic Surgery
Interventions: DEVICE: Patient monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: FoodRx for Obesity Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Food Insecurity
Interventions: BEHAVIORAL: BWL+VOUCHER|BEHAVIORAL: BWL+HOME|BEHAVIORAL: Behavioral weight loss counseling (BWL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nab-paclitaxel Plus Carboplatin Versus Nab-paclitaxel Plus Epirubicin in the Neoadjuvant Therapy for Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer|Triple-negative Breast Cancer|Nab-paclitaxel
Interventions: DRUG: Nab-paclitaxel + Carboplatin|DRUG: Nab-paclitaxel + Epirubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liraglutide Efficacy and Action in Non-Alcoholic Steatohepatitis
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis
Interventions: DRUG: Liraglutide|OTHER: Liraglutide-placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prostate Medication, Metabolism and Gut Microbiota
Status: RECRUITING
Conditions: Prostatic Hyperplasia|Prostate Cancer
Interventions: DRUG: Prostate hyperplasia medication|DRUG: LhRH-antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Randomized Study for Effectiveness and Safety Evaluation of Dexamethasone 0.5 mg + Fumarate Clemastine 1 mg Compared to Dexamethasone 0.5 mg in Patients With Allergic Dermatitis
Status: UNKNOWN
Conditions: Allergy|Dermatitis
Interventions: DRUG: Dexamethasone + clemastine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remembered Meal Satisfaction, Satiety and Later Snack Food Intake
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: BEHAVIORAL: Satisfying rehearsal task|BEHAVIORAL: Dissatisfying rehearsal task|BEHAVIORAL: Neutral rehearsal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Treatment of Acute Spinal Cord Injury by Near Infrared Light Irradiation
Status: UNKNOWN
Conditions: Spinal Cord Injuries|Photobiology|Neurological Rehabilitation|Near Infrared Light Irradiation
Interventions: PROCEDURE: Laminectomy|DEVICE: Spinal nerve laser therapeutic apparatus（Composed of 808-band fully automatic control laser device and implantable 360° scattering medical fiber）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Find The Best Dose Of SU011248 When Given With Pemetrexed, Pemetrexed And Cisplatin Or Pemetrexed And Carboplatin In Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Sunitinib, Pemetrexed, Cisplatin, Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Propafenone Versus Dronedarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Propafenone|DRUG: Dronedarone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Healing Process and Blood Sugar Level Following Local Anesthetic Infiltration With and Without Vasoconstrictor
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes|Anesthesia, Local
Interventions: DRUG: Local anaesthesia with vasocontrictor (Mepivacaine hydrochloride 20 mg (2%) + Levonordefrin hydrochloride 0.06 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Consistency Study for Three Commercial Lots of Inactivated Poliomyelitis Vaccine Made From Sabin Strain
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: sIPV batch 1|BIOLOGICAL: sIPV batch 2|BIOLOGICAL: sIPV batch 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of MRG003 in Patients With Recurrent Metastatic Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Recurrent or Metastatic Nasopharyngeal Carcinoma
Interventions: DRUG: MRG003|DRUG: Capecitabine tablets|DRUG: Docetaxel injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness, Safety and Tolerability Study of RP-G28 for Symptoms Associated With Lactose Intolerance
Status: COMPLETED
Conditions: Lactose Intolerance
Interventions: DRUG: RP-G28 or placebo|DRUG: RP-G28 or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation
Status: ACTIVE_NOT_RECRUITING
Conditions: NSCLC|EGFR Activating Mutation|Brain Metastases|Leptomeningeal Metastasis
Interventions: DRUG: TY-9591 Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing LY900014 to Insulin Lispro (Humalog) in Children and Adolescents With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: LY900014|DRUG: Insulin Lispro|DRUG: Insulin Glargine|DRUG: Insulin Degludec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT