pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Gene Therapy and Combination Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: AIDS-Related Burkitt Lymphoma|AIDS-Related Diffuse Large B-cell Lymphoma|AIDS-Related Plasmablastic Lymphoma|AIDS-Related Primary Effusion Lymphoma|HIV Infection|AIDS Related Non-Hodgkin Lymphoma
Interventions: DRUG: Prednisone|BIOLOGICAL: Rituximab|DRUG: Etoposide|DRUG: Doxorubicin Hydrochloride|DRUG: Vincristine Sulfate|DRUG: Cyclophosphamide|BIOLOGICAL: Filgrastim|BIOLOGICAL: Lentivirus Vector rHIV7-shI-TAR-CCR5RZ-transduced Hematopoietic Stem/Progenitor Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent Colorectal Cancer
Status: TERMINATED
Conditions: Adenocarcinoma of the Colon|Adenocarcinoma of the Rectum|Mucinous Adenocarcinoma of the Colon|Mucinous Adenocarcinoma of the Rectum|Recurrent Colon Cancer|Recurrent Rectal Cancer|Signet Ring Adenocarcinoma of the Colon|Signet Ring Adenocarcinoma of the Rectum|Stage IV Colon Cancer|Stage IV Rectal Cancer
Interventions: DRUG: irinotecan hydrochloride|DRUG: gefitinib|DRUG: leucovorin calcium|DRUG: fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyaluronic Acid 0.2% Application Enhanced Chronic Periodontitis Treatment in Non-surgical Phase
Status: COMPLETED
Conditions: Chronic Periodontitis, Hyaluronic Acid
Interventions: DRUG: 0.2% hyaluronic acid gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Vildagliptin on the Maximum Insulin Secretion in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Open-label Safety and Pharmacokinetic Study of DUEXIS® (Ibuprofen and Famotidine) Tablets in Juvenile Idiopathic Arthritis
Status: COMPLETED
Conditions: Juvenile Idiopathic Arthritis
Interventions: DRUG: 800 mg ibuprofen/26.6 mg famotidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Electronic Cigarette Use on the Lungs
Status: COMPLETED
Conditions: Current Smoker|Never Smoker|Tobacco Use Disorder|Former Smoker|E-cig User
Interventions: PROCEDURE: Bronchoscopy|OTHER: Electronic Cigarette|OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Photodynamic Therapy Using Topical Aminolevulinic Acid in Treating Patients With Actinic Keratosis
Status: TERMINATED
Conditions: Precancerous/Nonmalignant Condition
Interventions: DRUG: aminolevulinic acid|PROCEDURE: laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study to Compare the Systemic Exposure of Differin® Gel, 0.3% or Differin® Gel, 0.1%
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Adapalene|DRUG: Adapalene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Investigate the Efficacy and Safety of Ondansetron (Danset - Adwia) Versus Placebo Plus the Standard of Care in the Treatment of Nausea and Vomiting in Adult Patients With Acute Gastroenteritis
Status: NOT_YET_RECRUITING
Conditions: Gastroenteritis
Interventions: DRUG: Ondansetron 8 mg ampoule|DRUG: Metoclopramide 10 mg ampoule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Frailty, a Prevalent Syndrome in the Senior Population, Manifests as a Decline in Oral Functions, Often Coupled With Diminished Cognitive and Physical Capabilities.
Status: NOT_YET_RECRUITING
Conditions: Frailty
Interventions: BEHAVIORAL: Oral Health Intervention|BEHAVIORAL: SMS intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-Operative Dural Brachytherapy With Yttrium-90 Plaque Applicators
Status: TERMINATED
Conditions: Spinal Neoplasms
Interventions: DEVICE: Yttrium-90 Plaque Applicator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot of Lifestyle Behavior Intervention for Non-Alcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: BEHAVIORAL: Healthy Liver/Hígado Sano program|BEHAVIORAL: Usual standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Smoking Cessation CM for Veterans With or at Risk for Cancer
Status: NOT_YET_RECRUITING
Conditions: Tobacco Use Disorder|Substance Use Disorder
Interventions: BEHAVIORAL: Focus Group|BEHAVIORAL: Contingency Management|BEHAVIORAL: Behavioral Counseling (Cognitive Behavioral Therapy, CBT)|BEHAVIORAL: TUD Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Commercial "Sleep Lotion" on Salivary Melatonin Levels and Sleep Quality in Undergraduates
Status: COMPLETED
Conditions: Sleep
Interventions: OTHER: Melatonin sleep lotion|OTHER: Placebo control lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: ExAblate Transcranial MRgFUS of the Globus Pallidum for Treatment of Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DEVICE: ExAblate Transcranial System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stroke Prevention Rehabilitation Intervention Trial of Exercise (SPRITE)
Status: COMPLETED
Conditions: Cerebrovascular Disorders
Interventions: OTHER: 'The Healthy Brain Rehabilitation Manual'|DEVICE: Pedometer|PROCEDURE: Usual care|BEHAVIORAL: Telephone follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Lisdexamfetamine Dimesylate for Promoting Occupational Success in Young Adults With ADHD
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: Lisdexamfetamine Dimesylate 40 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Listening to Relatives' Voice Recordings on Chest Pain, Anxiety, and Depression in Coronary ICU Patients
Status: COMPLETED
Conditions: Acute Myocardial Infarction|Intensive Care Unit Syndrome
Interventions: OTHER: Relatives vioce record
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetic a Single Day of Dosing With GSK1614235.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: GSK2330672|DRUG: Placebo|DRUG: GSK1614235
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Real-time Early Detection of Nephrotoxicity by Urinary Biomarker Analysis With SeroFlow Technology
Status: RECRUITING
Conditions: Acute Kidney Injury
Interventions: DIAGNOSTIC_TEST: AKI risk screening using RenaFAST POCT test kits
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Groin Complications in Open vs. Percutaneous Peripheral Cannulation in Minimally Invasive Cardiac Surgery
Status: NOT_YET_RECRUITING
Conditions: Cardiovascular Diseases
Interventions: PROCEDURE: Open cannulation|PROCEDURE: Percutaneous cannulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS)
Status: NOT_YET_RECRUITING
Conditions: Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome
Interventions: DRUG: ION440|PROCEDURE: Sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Healthy Recovery After Trauma Study
Status: RECRUITING
Conditions: Stress Disorders, Post-Traumatic|Shame|Guilt|Sexual Assault and Rape
Interventions: BEHAVIORAL: Cognitive Processing Therapy|BEHAVIORAL: Self-Compassion Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Generalized Seizure Detection And Alerting In The EMU With The Empatica Embrace Watch And Smartphone-Based Alert System
Status: UNKNOWN
Conditions: Epilepsy
Interventions: DEVICE: Additional Seizure Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 2a Dose Escalation Study With SLV334 in Patients With Traumatic Brain Injury.
Status: TERMINATED
Conditions: Traumatic Brain Injury
Interventions: DRUG: SLV334|DRUG: SLV334|DRUG: SLV334|DRUG: SLV334|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nalbuphine as an Adjuvant to Intravenous Regional Anesthesia
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Nalbuphine|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Computer-Guided Glucose Management Systems in Treating Patients With Hyperglycemia Who Have Undergone Blood and Bone Marrow Transplant
Status: COMPLETED
Conditions: Hyperglycemia|Malignant Neoplasm
Interventions: OTHER: computer-assisted intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Postoperative Pain Relief After Major Abdominal Gynecological Surgery
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: PROCEDURE: lumbar epidural analgesia with bupivacaine|PROCEDURE: transversus abdominis plane block with bupivacaine|PROCEDURE: wound infiltration with bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MoveStrong at Home: A Feasibility Study of a Model for Remote Delivery of Functional Strength and Balance Training Combined With Nutrition Education for Older Pre-frail Adults.
Status: COMPLETED
Conditions: Arthritis|Cancer|Cardiovascular Diseases|Chronic Lung Disease|Congestive Heart Failure|Diabetes|Hypertension|Kidney Diseases|Obesity|Osteoporosis|Stroke|Frailty
Interventions: OTHER: Exercise program|OTHER: Nutrition education
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Association of L-asparaginase-Methotrexate-Dexamethasone for Nasal and Nasal-type Natural Killer (NK)-T-cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: Kidrolase|DRUG: Methotrexate|DRUG: Dexamethasone|DRUG: Erwinase
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 24-Hour Pharmacokinetic Determination of BG00012 After Single-Day Oral Administration in Subjects With MS
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: BG00012|DRUG: BG00012
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: NeuroSeq: A Prospective Trial to Evaluate the Diagnostic Yield of Whole Genome Sequencing (WGS) in Adult Neurology
Status: COMPLETED
Conditions: Neurologic Deficits|Neurologic Disorder|Neurologic Abnormalities
Interventions: OTHER: clinical Whole Genome Sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: In Situ Vaccine for Low-Grade Lymphoma: Combination of Intratumoral Flt3L and Poly-ICLC With Low-Dose Radiotherapy
Status: COMPLETED
Conditions: Low-Grade B-cell Lymphoma
Interventions: DRUG: rhuFlt3L/CDX-301|DRUG: Poly-ICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Indocyanine Green or Trypan Blue for Delamination of the Internal Limiting Membrane in Macular Hole Surgery
Status: COMPLETED
Conditions: Idiopathic Macular Hole
Interventions: PROCEDURE: Delamination of the Internal limiting membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Microwave Thermotherapy Before Surgery in Treating Women With Locally Advanced Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|PROCEDURE: thermal ablation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Specific T Cell Derived Exosomes (CSTC-Exo)
Status: UNKNOWN
Conditions: Corona Virus Infection|Pneumonia
Interventions: BIOLOGICAL: COVID-19 Specific T Cell derived exosomes (CSTC-Exo)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 1 Study to Evaluate the Pharmacokinetics of GS-5816 in Subjects With Normal Hepatic Function and Moderate or Severe Hepatic Impairment
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: GS-5816
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Greater Occipital and Supraorbital Nerve Blockade in Migraine Patients
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: PROCEDURE: Lidocaine injections|PROCEDURE: Saline injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of VIR-2218, VIR-3434, and/or PEG-IFNα in Subjects With Chronic Hepatitis B Virus Infection
Status: RECRUITING
Conditions: Hepatitis B, Chronic
Interventions: DRUG: VIR-2218|DRUG: VIR-3434|DRUG: PEG-IFNα
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The First Therapeutic Intervention in Malignant Pleural Effusion Trial
Status: COMPLETED
Conditions: Malignant Pleural Effusion|Pleural Effusion
Interventions: OTHER: Large bore chest drain + NSAID based analgesic regimen|OTHER: Small bore chest drain + NSAID based analgesic regimen|OTHER: Large bore chest drain + opiate based analgesic regimen|OTHER: Small bore chest drain + opiate based analgesic regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of the Mind/Body Program for Fertility, Hungarian Version, on Well-Being and Assisted Reproduction Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Infertility, Female
Interventions: BEHAVIORAL: Mind/Body Program for Fertility (Domar et al., 2011)|BEHAVIORAL: Fertility Support Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Testing the Ability of JNJ-18038683 to Improve Cognition and Reduce Depressive Symptoms in Stable Bipolar Patients
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: JNJ-18038683|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Decline in Non-demented PD
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Strattera|DRUG: Exelon|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Imaging or Ultrasound in Soft Tissue Tumors (MUSTT)
Status: UNKNOWN
Conditions: Sarcoma|Soft Tissue Tumors|Ultrasound|Magnetic Resonance Imaging|Diagnostic Accuracy|Sensitivity|Specificity|Follow-up
Interventions: OTHER: Ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: High Resolution Optical Coherence Tomography
Status: RECRUITING
Conditions: Retinal Disease|Retinal Detachment|Retinal Vein Occlusion|Retinal Dystrophy|Retinal Artery Occlusion|Retinal Edema|Retinal Neovascularization|Uveitis|Diabetic Retinopathy|Diabetic Macular Edema|Macular Edema|Macular Degeneration|Macular Disease|Glaucoma|Optic Nerve Diseases|Hypertensive Retinopathy
Interventions: DEVICE: High-resolution optical coherence tomography (High-Res-OCT)|DEVICE: Standard spectral domain OCT (SD-OCT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PXD101 and 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Metastatic or Unresectable Solid Tumors or Lymphoma
Status: TERMINATED
Conditions: Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Post-transplant Lymphoproliferative Disorder|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Adult T-cell Leukemia/Lymphoma|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Mycosis Fungoides/Sezary Syndrome|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Adult T-cell Leukemia/Lymphoma|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Mycosis Fungoides/Sezary Syndrome|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific|Waldenström Macroglobulinemia
Interventions: DRUG: tanespimycin|DRUG: belinostat|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduction of Drug Use and HIV Risk Among Out-of-Treatment Methamphetamine Users
Status: COMPLETED
Conditions: HIV Infections
Interventions: BEHAVIORAL: HIV Testing and Counseling|BEHAVIORAL: Contingency Management|BEHAVIORAL: Strengths-based case management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Olanzapine Versus Placebo in Treating Outpatients With Anorexia Nervosa
Status: COMPLETED
Conditions: Eating Disorders
Interventions: DRUG: Olanzapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PET and MRI Imaging With Scopolamine at the Muscarinic M1 Receptor
Status: NOT_YET_RECRUITING
Conditions: Muscarinic Receptor Occupancy
Interventions: DRUG: Scopolamine|RADIATION: [11C]EMO ([11C]LSN3172176)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Investigate the Pharmacokinetics and Safety of Fluticasone Furoate (FF)/ Umeclidinium (UMEC) Combination Compared With FF and UMEC Monotherapies in Adult Healthy Volunteers Using a Dry Powder Inhaler (DPI)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: FF 400 mcg|DRUG: UMEC 500 mcg|DRUG: FF/UMEC 400/500 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine INO-3112 and Durvalumab in Treating Patients With Recurrent or Metastatic Human Papillomavirus Associated Cancers
Status: TERMINATED
Conditions: Human Papillomavirus-16 Positive|Human Papillomavirus-18 Positive|Metastatic Malignant Neoplasm|Recurrent Anal Canal Carcinoma|Recurrent Cervical Carcinoma|Recurrent Malignant Neoplasm|Recurrent Penile Carcinoma|Recurrent Vaginal Carcinoma|Recurrent Vulvar Carcinoma|Refractory Malignant Neoplasm|Stage IV Anal Cancer AJCC v8|Stage IV Cervical Cancer AJCC v8|Stage IV Penile Cancer AJCC v8|Stage IV Vaginal Cancer AJCC v8|Stage IV Vulvar Cancer AJCC v8|Stage IVA Cervical Cancer AJCC v8|Stage IVA Vaginal Cancer AJCC v8|Stage IVA Vulvar Cancer AJCC v8|Stage IVB Cervical Cancer AJCC v8|Stage IVB Vaginal Cancer AJCC v8|Stage IVB Vulvar Cancer AJCC v8
Interventions: BIOLOGICAL: DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine MEDI0457|BIOLOGICAL: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LGG/BB12-pastille Study
Status: COMPLETED
Conditions: Probiotics
Interventions: DIETARY_SUPPLEMENT: Probiotics in an pastille|DIETARY_SUPPLEMENT: Control pastille
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Situational Problem Solving in Adolescents With Type 2 Diabetes: Enhancing a Randomized Controlled Trial (RCT)
Status: COMPLETED
Conditions: Adolescents With Type 2 Diabetes
Interventions: BEHAVIORAL: Comprehensive intervention (disease management program)|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Open Labeled Placebo in Reducing Cancer Related Fatigue in Patients With Advanced Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm|Recurrent Malignant Solid Neoplasm
Interventions: OTHER: Placebo Administration|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|OTHER: Waiting List
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nebulized 3% Hypertonic Saline Solution Treatment of Bronchiolitis in Infants
Status: COMPLETED
Conditions: Bronchiolitis|Wheezing
Interventions: DRUG: 0.9% Sodium Chloride|DRUG: 3% Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3209590 in Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: LY3209590|DRUG: Insulin Degludec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of PG201 Tablet in Patients With Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: OTHER: PG201|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer
Status: RECRUITING
Conditions: NSCLC|Low Dose Radiotherapy|PD-1 Inhibitor|Leptomeningeal Metastasis
Interventions: RADIATION: Whole Brain Low Dose Radiotherapy|DRUG: Pemetrexed|DRUG: Sintilimab|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of CAELYX in Patients With Metastatic Breast Cancer Previously Treated With Anthracyclines (Study P04057)(TERMINATED)
Status: TERMINATED
Conditions: Breast Neoplasm
Interventions: DRUG: Pegylated Liposomal Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Single Rising Doses of BI 705564 and Food Effect on BI 705564 in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Placebo|DRUG: BI 705564 (Test)|DRUG: BI 705564 (Reference)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: BI 705564 in Patients With Systemic Lupus Erythematosus (SLE)
Status: WITHDRAWN
Conditions: Lupus Erythematosus, Systemic
Interventions: DRUG: BI 705564|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone Treatment of Congenital Adrenal Hyperplasia
Status: COMPLETED
Conditions: Adrenal Hyperplasia, Congenital
Interventions: DRUG: dexamethasone|DRUG: Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Magnetic Resonance-Guided Radiofrequency-Ablation for Atrial Flutter II
Status: COMPLETED
Conditions: Atrial Flutter
Interventions: PROCEDURE: ablation for typical atrial flutter|DEVICE: catheter ablation with study device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contribution Of Nuclear Magnetic Resonance Imaging In The Study Of Diabetic Cardiomyopathy
Status: UNKNOWN
Conditions: Diabetic|Cardiomyopathy
Interventions: OTHER: NUCLEAR MAGNETIC RESONANCE IMAGING|OTHER: NUCLEAR MAGNETIC RESONANCE IMAGING
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of M200 (Volociximab) in Patients With Metastatic Renal Cell Carcinoma (RCC)
Status: TERMINATED
Conditions: Renal Cell Carcinoma|Metastases
Interventions: DRUG: Volociximab (anti-α5β1 integrin monoclonal antibody)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Extension Study of Ontamalimab in Participants With Moderate to Severe Ulcerative Colitis or Crohn's Disease (AIDA)
Status: COMPLETED
Conditions: Crohn's Disease|Ulcerative Colitis
Interventions: DRUG: 25 mg Ontamalimab|DRUG: 75 mg Ontamalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Skin Cancer Prevention With Nicotinamide in Transplant Recipients - Pilot Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-melanoma Skin Cancer|Carcinoma, Squamous Cell|Carcinoma, Basal Cell
Interventions: DRUG: Nicotinamide|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Incidence of HIV Infection in Screening Indian Men Who Have Sex With Men
Status: NOT_YET_RECRUITING
Conditions: HIV Infection
Interventions: OTHER: Cytology Specimen Collection Procedure|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Medical Examination|PROCEDURE: Physical Examination|PROCEDURE: Proctoscopy with Biopsy|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Atezolizumab Compared With Docetaxel in Non-Small Cell Lung Cancer (NSCLC) After Failure With Platinum-Containing Chemotherapy
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Atezolizumab (MPDL3280A), an engineered anti-PD-L1 antibody|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Self-thoracic Spine Mobilization on Improving Sleep Quality in Patients Who Have Shoulder Pain
Status: COMPLETED
Conditions: Shoulder Pain Chronic
Interventions: PROCEDURE: Self-mobilization|PROCEDURE: Sleep Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Immunological Long-term Persistence of Antibodies (Abs) 2 Years After GlaxoSmithKline (GSK) Meningococcal ABCWY Vaccination in the V102_15 (NCT02212457) and Response to a Booster in Adolescents
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: Meningococcal ABCWY Vaccine|BIOLOGICAL: Meningococcal B Recombinant vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of the CRRT Management Protocol on Prognostic Outcome in Patients With Septic Acute Kidney Injury
Status: COMPLETED
Conditions: To Explore the Influence of CRRT Nursing Team Management Plan on the Prognosis of SAKI Patients
Interventions: OTHER: Implement the CRRT specialist nursing group management program on the basis of routine care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of a 3-Part Skin Care Regimen on Facial Wrinkles and Biophysical Attributes
Status: ACTIVE_NOT_RECRUITING
Conditions: Wrinkle
Interventions: OTHER: Cleansing Balm|OTHER: Facial Serum|OTHER: Moisturizer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 4 COPD and Suboptimal Inspiratory Flow Rate
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Revefenacin|DRUG: Tiotropium|DRUG: Revefenacin Placebo|DRUG: Tiotropium Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Atezolizumab With or Without Tiragolumab Consolidation in Limited Stage Small Cell Lung Cancer
Status: TERMINATED
Conditions: Carcinoma, Small Cell Lung
Interventions: DRUG: Atezolizumab|DRUG: Tiragolumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Laminoplasty for Multilevel Cervical Spondylotic Myelopathy Guided by Modified K-line and Modified SC-line in MRI
Status: RECRUITING
Conditions: Modified K-line and Modified SC-line in MRI
Interventions: DIAGNOSTIC_TEST: No Intervention: MCSM
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of Print Messages to Support the Role of Partners in Promoting Provider Discussions About Prostate Cancer Screening Among AA Men
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BEHAVIORAL: Partner and CDC brochure condition|BEHAVIORAL: CDC brochure only condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 1 Study of CC-486 as a Single Agent and in Combination With Carboplatin or ABI-007 in Subjects With Relapsed or Refractory Solid Tumors
Status: COMPLETED
Conditions: Urinary Bladder Neoplasms|Carcinoma, Transitional Cell|Ovarian Neoplasms|Fallopian Tube Neoplasms|Peritoneal Neoplasms|Carcinoma, Non-Small-Cell Lung|Carcinoma, Pancreatic Ductal|Tumor Virus Infections
Interventions: DRUG: CC-486|DRUG: Carboplatin|DRUG: ABI-007
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accuracy of Static Computer-assisted Implant Surgery in Distal Free-end Scenarios
Status: COMPLETED
Conditions: Dental Implant|Computer-assisted
Interventions: PROCEDURE: Static computer-assisted guided surgery with analogic guide|PROCEDURE: Static computer-assisted guided surgery with CAD-CAM surgical guide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Transfer of FRozen Encapsulated Multidonor Stool Filtrate for Active Ulcerative COlitis
Status: RECRUITING
Conditions: Ulcerative Colitis|Inflammatory Bowel Diseases
Interventions: DRUG: encapsulated faecal microbiota filtrate|DRUG: encapsulated faecal microbiota|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Muscle Effects of BYM338 in Mechanically Ventilated Patients
Status: WITHDRAWN
Conditions: Mechanical Ventilation
Interventions: DRUG: BYM338|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study of the Pharmacokinetics, Pharmacodynamics, and Safety of ARC1779 Injection in Patients With Von Willebrand Disease Type 2B
Status: WITHDRAWN
Conditions: Von Willebrand Disease
Interventions: DRUG: ARC1779|DRUG: ARC1779|DRUG: ARC1779|DRUG: ARC1779
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of Ondansetron 16 mg Orally Disintegrating Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ondansetron|DRUG: Zofran ODT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Switching Regimen in Treating Cirrhotic HCV GT1b Subjects
Status: UNKNOWN
Conditions: Chronic Hepatitis C Infection
Interventions: DRUG: PR4 + LDV/SOF + ASV 4 wk|DRUG: PR4 + LDV/SOF + SMV 4 wk|DRUG: PR4 + LDV/SOF + ASV 6 wk|DRUG: PR4 + LDV/SOF + SMV 6 wk|DRUG: PR4 + LDV/SOF + ASV 8 wk|DRUG: PR4 + LDV/SOF + SMV 8 wk|DRUG: PR4 + LDV/SOF + ASV 12 wk|DRUG: PR4 + LDV/SOF + SMV 12 wk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Randomized Study Comparing Renal Artery Stenting (RESIST)With/Without Distal Protection
Status: COMPLETED
Conditions: Renal Artery Stenosis
Interventions: DEVICE: Renal Artery Stent with Protective Device/Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Albumin Replacement Therapy in Septic Shock
Status: UNKNOWN
Conditions: Septic Shock
Interventions: DRUG: Albutein® 200 g/L or Plasbumin® 20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Blood Pressure in Patients With High Cardiovascular Risk in the Safety-Net
Status: RECRUITING
Conditions: Myocardial Infarction|Hypertension|Stroke
Interventions: BEHAVIORAL: BP REACH Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assess the Feasibility and Safety of Granulocyte Colony Stimulating Factor (GCSF) Mobilization of CD34+ Hematopoietic Progenitor Cells in Patients With Betathalassemia Major
Status: COMPLETED
Conditions: Beta Thalassemia Major|Congenital Anemias
Interventions: GENETIC: GCSF, Central venous line placement, Stem cell Collection (leukapheresis)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medicine Adherence and Effects on Transplants With Pilloxa's Electronic Pillbox
Status: TERMINATED
Conditions: Kidney Transplant; Complications|Liver Transplant; Complications
Interventions: DEVICE: Pilloxa Pillbox|OTHER: Non active Pilloxa Pillbox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Access the Relative Bioavailability of Subcutaneous Dose of Nemolizumab When Administered Via Auto-Injector Versus Dual-Chamber Syringe
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Nemolizumab|DRUG: Nemolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dose Influenza in Immunosuppressed Subjects
Status: WITHDRAWN
Conditions: Influenza
Interventions: BIOLOGICAL: Trivalent inactivated influenza vaccine|BIOLOGICAL: Trivalent Baculovirus-expressed Influenza HA vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Mobile Phone Based Pilot Intervention to Prevent Obesity in Latino Preschool Children
Status: UNKNOWN
Conditions: Childhood Obesity|Parenting|Mobile Phone Use
Interventions: BEHAVIORAL: healthy weight behaviors supported by web-based mobile phone application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Pitavastatin on Erythrocyte Membrane Fatty Acid Contents in Patients With Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Pitavastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for Lumbar Pain
Status: RECRUITING
Conditions: Low Back Pain
Interventions: BIOLOGICAL: Lumbar Injections with 10cc's of Wharton's Jelly Allograft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of an Eye-Cervical Re-education Program in Chronic Neck Pain
Status: COMPLETED
Conditions: Neck Pain|Eye Strain
Interventions: OTHER: EYE-CERVICAL RE-EDUCATION PROGRAM|OTHER: Combined Physiotherapy Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Optimal Dose of Org 36286 to Induce Monofollicular Ovulation in Women With WHO Group II Anovulatory Infertility (P07016)
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Org 36286|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Diazepam After Whiplash : A Randomized Controlled Study
Status: COMPLETED
Conditions: Whiplash Injuries|Whiplash Injury of Cervical Spine
Interventions: DRUG: Diazepam Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Safety, Tolerability and Immune Response of Meningococcal Combined ABCWY Vaccine in Healthy Infants
Status: ACTIVE_NOT_RECRUITING
Conditions: Infections, Meningococcal
Interventions: COMBINATION_PRODUCT: MenABCWY-2Gen low dose vaccine|COMBINATION_PRODUCT: MenABCWY-2Gen high dose vaccine|COMBINATION_PRODUCT: MenABCWY-1Gen vaccine|COMBINATION_PRODUCT: MenB vaccine|COMBINATION_PRODUCT: MenACWY-TT vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: TrueRelief Efficacy for Supraspinatus Tendonitis
Status: WITHDRAWN
Conditions: Supraspinatus Tendinitis|Shoulder Pain
Interventions: DEVICE: TrueRelief device|DEVICE: Sham TrueRelief device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Anti-tumor Necrosis Factor Therapy in Patients With Takayasu Arteritis
Status: UNKNOWN
Conditions: Takayasu's Arteritis
Interventions: DRUG: remicade (anti tumor necrosis factor inhibitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Midodrine for Prophylaxis Against Post Spinal Hypotension in Elderly Population
Status: COMPLETED
Conditions: Hypotension|Spinal Anesthesia|Elderly
Interventions: DRUG: Midodrine Oral Tablet|DRUG: Metoclopramide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: African American Preference for Knee Replacement: A Patient-Centered Intervention
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: BEHAVIORAL: Decision Aid (DA) Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Identification of Gluten Sensitivity in Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Non-celiac Gluten Sensitivity|Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: diet containing gluten|DIETARY_SUPPLEMENT: Diet containing placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Topic Trial - Study to Determine the Safety and Efficacy of Ivacaftor
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Chronic Bronchitis
Interventions: DRUG: Ivacaftor 150 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lutronic PicoPlus Exploratory Clinical Trial
Status: TERMINATED
Conditions: Tattoo; Pigmentation|Melasma|Benign Pigmented Lesion
Interventions: DEVICE: PicoPlus laser system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a New Combination of Nutraceuticals (AkP06) Without Monacolin K on Plasma Lipids and Glucose
Status: COMPLETED
Conditions: Cardiovascular Risk Factor
Interventions: DIETARY_SUPPLEMENT: AkP06|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safer Aging With Diabetes Monitoring
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Hypoglycemia
Interventions: BEHAVIORAL: SAGE Group Sessions|BEHAVIORAL: SAGE Group Sessions + Diabetes Pharmacist|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Evaluating the Safety, Tolerability, and Initial Efficacy of IBI110 in Subjects With Advanced Malignant Tumors
Status: UNKNOWN
Conditions: Advanced Malignancies
Interventions: DRUG: IBI110|DRUG: IBI110|DRUG: IBI110+ Sintilimab|DRUG: IBI110+ Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT