pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Methotrexate in Erosive Inflammatory Hand Osteoarthritis
Status: RECRUITING
Conditions: Hand Osteoarthritis|Erosive Osteoarthritis
Interventions: DRUG: Methotrexate Tablets|DRUG: Placebo|DRUG: Folic Acid 1 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Pharmacokinetics of Guaifenesin in Adults and Adolescents
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Children's Mucinex® Grape Flavor|DRUG: Children's Mucinex® Grape Flavor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ask Questions (ASQ):Implementation of a Communication Intervention
Status: COMPLETED
Conditions: Stage II Breast Cancer|Stage III Breast Cancer|Stage IV Breast Cancer|Stage II Colorectal Cancer|Stage III Colorectal Cancer|Stage IV Colorectal Cancer|Stage II Lung Cancer|Stage III Lung Cancer|Stage IV Lung Cancer|Stage II Prostate Cancer|Stage III Prostate Cancer|Stage IV Prostate Cancer|Stage II Ovarian Cancer|Stage III Ovarian Cancer|Stage IV Ovarian Cancer|Stage II Cervical Cancer|Stage III Cervical Cancer|Stage II Bladder Cancer|Stage III Bladder Cancer|Stage IV Bladder Cancer|Stage II Kidney Cancer|Stage III Kidney Cancer|Stage IV Kidney Cancer
Interventions: BEHAVIORAL: Behavioral Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparative Trial Evaluating Safety and Immunogenicity of an Adjuvanted and a Conventional Influenza Vaccine in Elderly Subjects (> 60 Years)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: Tenotomy or Tenodesis of Long Head Biceps in Arthroscopic Rotator Cuff Repair
Status: COMPLETED
Conditions: Rotator Cuff Syndrome
Interventions: PROCEDURE: Arthroscopic rotator cuff repair|PROCEDURE: LHB Tenodesis|PROCEDURE: LHB Tenotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes of Open Wedge High Tibial Osteotomy With Autologous Bone Marrow or Adipose-derived Stem Cell Therapy
Status: UNKNOWN
Conditions: Osteoarthritis|Genu Varum
Interventions: PROCEDURE: HTO with microfracture|PROCEDURE: Transplantation of bone marrow stem cell|PROCEDURE: Transplantation of adipose derived stem cell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intracavitary Carrier-embedded Cs131 Brachytherapy for Recurrent Brain Metastases: a Randomized Phase II Study
Status: RECRUITING
Conditions: Recurrent Brain Metastases
Interventions: PROCEDURE: Craniotomy|RADIATION: Cesium-131 brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of UI05MSP015CT in Functional Dyspepsia
Status: COMPLETED
Conditions: Functional Dyspepsia
Interventions: DRUG: UI05MSP015CT|DRUG: Gasmotin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Practical Ultrasonographic Detection of Sarcopenia in Patients With Long-term Gastrectomy
Status: COMPLETED
Conditions: Sarcopenia|Gastrectomy
Interventions: DIAGNOSTIC_TEST: USG, Grip strength, Chair stand test (CST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Acupuncture and Low-Level Laser in Temporomandibular Disorders
Status: UNKNOWN
Conditions: Temporomandibular Joint Disorders
Interventions: DEVICE: Low-Level Laser Therapy+acupuncture|DEVICE: Low-Level Laser Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Feasibility of a Physiologic Biomarker to Assess Pain and Other Sensory Problems Using Pupillometry in Participants With Neurofibromatosis Type 1 (NF1)
Status: NOT_YET_RECRUITING
Conditions: Neurofibromatosis Type 1
Interventions: DEVICE: AlgometRx Nociometer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Clinical Study Evaluating the Safety and Efficacy of IDP-110 in Patients With Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: IDP-110|DRUG: Clindamycin|DRUG: Benzoyl peroxide|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Human Menstrual Blood-derived Mesenchymal Stem Cells for Patients With Liver Cirrhosis
Status: UNKNOWN
Conditions: Liver Cirrhosis|Fibrosis|Liver Disease|Digestive System Disease
Interventions: BIOLOGICAL: conventional therapy plus MenSC transplantation|DRUG: Conventional therapy plus placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Articaine Efficacy and Safety for 3 Years Old Children
Status: NOT_YET_RECRUITING
Conditions: Dental Caries in Children|Dental Diseases|Pulp Disease, Dental|Behavior, Child
Interventions: DRUG: Mepivacaine 2% with epinephrine 1:100,000|DRUG: Articaine (4%) with epinephrine 1:100,000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MRD-Directed Consolidation With Epcor-only or Epcor-R2 Post Anti-CD19 CAR TCell Therapy for Large B-Cell Lymphoma
Status: RECRUITING
Conditions: Relapsed/Refractory Large B-cell Lymphoma
Interventions: DRUG: Epcoritamab|DRUG: Epcoritamab, lenalidomide and rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Activate For Life: mHealth Intervention To Address Pain And Fatigue In Low-income Older Adults Aging In Place
Status: COMPLETED
Conditions: Pain, Chronic|Fatigue Syndrome, Chronic|Aging
Interventions: BEHAVIORAL: Otago|BEHAVIORAL: Gentle yogic breathing|BEHAVIORAL: Behavioral Activation|BEHAVIORAL: Caregiver Gentle yogic breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Everolimus, Fluorouracil, Leucovorin, Panitumumab, and Oxaliplatin in Treating Patients With Tumors That Did Not Respond to Treatment
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: panitumumab|DRUG: everolimus|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Trial of ZD4054 (Zibotentan) (Endothelin A Antagonist) in Non-metastatic Hormone Resistant Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: ZD4054|DRUG: Palcebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Long Term Study of ALKS 5461 in the Treatment of Refractory Major Depressive Disorder (MDD)
Status: TERMINATED
Conditions: Refractory Major Depressive Disorder
Interventions: DRUG: ALKS 5461
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Combination Therapy for Angina of Coronary Heart Disease With Aspirin and Salvianolate Injection
Status: UNKNOWN
Conditions: Angina
Interventions: DRUG: Salvianolate injection|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MAP-Calcification: MicroRNAs as Potential Biomarkers for Coronary Artery Calcification
Status: COMPLETED
Conditions: Coronary Artery Calcification|Coronary Artery Disease|Osteoporosis|Osteopenia
Interventions: OTHER: Venous blood sampling|OTHER: 4-day food diary|OTHER: 1 week UV dosimeter|RADIATION: Peripheral Quantitative Computed Tomography of the radius
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Investigate the Safety and Efficacy of BOL-303224 in the Treatment of Bacterial Conjunctivitis
Status: COMPLETED
Conditions: Acute Bacterial Conjunctivitis
Interventions: DRUG: Besifloxacin|DRUG: Moxifloxacin solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Artificial Intelligent Clinic and Normal Clinic
Status: COMPLETED
Conditions: Cataract
Interventions: PROCEDURE: artificial intelligent clinic|PROCEDURE: normal clinic|PROCEDURE: experts diagnose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Whole-Body Vibration and High Impact Exercises in Postmenopausal Women
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal|Exercise Therapy
Interventions: DEVICE: Whole-body vibration exercise|OTHER: High-impact exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Marketed Silicone Hydrogel Lenses
Status: COMPLETED
Conditions: Refractive Error
Interventions: DEVICE: Lotrafilcon B contact lenses|DEVICE: Samfilcon A contact lenses|DEVICE: Hydrogen peroxide solution|DEVICE: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: A Study of TQ05105 Tablets in Subjects With Hemophagocytic Lymphohistiocytosis（HLH）
Status: UNKNOWN
Conditions: Hemophagocytic Lymphohistiocytosis
Interventions: DRUG: TQ05105
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Vein (PV) -Isolation: Arrhythmogenic Vein(s) Versus All Veins
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Segmental PV-Isolation of the arrhythmogenic vein(s)|PROCEDURE: Segmental PV-Isolation of all veins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pitavastatin and PCSK9 Inhibitors in Liver Transplant Patients
Status: RECRUITING
Conditions: Dyslipidemias|Hyperlipidemias|Liver Transplant Disorder|Immunosuppression|Hydroxymethylglutaryl-CoA Reductase Inhibitors|Statins
Interventions: DRUG: Pitavastatin|DRUG: PCSK9 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extended Infant Post-exposure Prophylaxis With Antiretrovirals to Reduce Postnatal HIV Transmission
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Nevirapine|DRUG: AZT|DRUG: NVP and AZT|DRUG: NVP|DRUG: NVP+AZT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: DFF332 as a Single Agent and in Combination With Everolimus & Immuno-Oncology Agents in Advanced/Relapsed Renal Cancer & Other Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: DFF332|DRUG: RAD001|DRUG: PDR001|DRUG: NIR178
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Explore the Role of Gut Flora in Chronic Constipation
Status: UNKNOWN
Conditions: Constipation|Constipation Chronic Idiopathic|Constipation - Functional|Constipation (Excl Faecal Impaction)
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prenatal Iodine Supplementation and Early Childhood Neurodevelopment
Status: ACTIVE_NOT_RECRUITING
Conditions: Pregnancy Related|Neurodevelopmental Disorders|Nutrition Disorder, Fetal
Interventions: COMBINATION_PRODUCT: Low Iodine Supplement|COMBINATION_PRODUCT: Standard Iodine Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Long-term Safety of Tazemetostat
Status: ENROLLING_BY_INVITATION
Conditions: Diffuse Large B-cell Lymphoma (DLBCL)|Follicular Lymphoma (FL)|Synovial Sarcoma|Epitheliod Sarcoma (ES)|Mesothelioma|Advanced Solid Tumors|Renal Medullary Carcinoma|Non-Hodgkin Lymphoma (NHL)
Interventions: DRUG: Tazemetostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study on the Effects of a Plant-Strong Diet on Cardiovascular Risk Factors
Status: COMPLETED
Conditions: Hyperlipidemias|Overweight and Obesity|Diabetes
Interventions: BEHAVIORAL: TeleMOVE!|BEHAVIORAL: Culinary Rx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults
Status: RECRUITING
Conditions: Insulin Resistance|Impaired Glucose Tolerance|Obesity|Metabolic Disturbance
Interventions: BEHAVIORAL: Low Physical Activity and Added Carbohydrate Group|BEHAVIORAL: Low physical Activity Control|BEHAVIORAL: High Physical Activity and Added Carbohydrate Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Comparison of Two Total Hip Replacements: Hip Resurfacing System Versus Mallory-Head/Exeter
Status: COMPLETED
Conditions: Osteoarthrosis
Interventions: DEVICE: ReCap, Hip resurfacing system, Biomet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Personalised Modeling and Simulations for the Differential Diagnosis of Dynapenia: Study on Patients With Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DIAGNOSTIC_TEST: Personalised Musculoskeletal Modeling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Idarubicin and Cytarabine With or Without Bevacizumab in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Childhood Acute Basophilic Leukemia|Childhood Acute Eosinophilic Leukemia|Childhood Acute Erythroleukemia (M6)|Childhood Acute Megakaryocytic Leukemia (M7)|Childhood Acute Monoblastic Leukemia (M5a)|Childhood Acute Monocytic Leukemia (M5b)|Childhood Acute Myeloblastic Leukemia With Maturation (M2)|Childhood Acute Myeloblastic Leukemia Without Maturation (M1)|Childhood Acute Myelomonocytic Leukemia (M4)|Secondary Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia|Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
Interventions: DRUG: idarubicin|DRUG: cytarabine|BIOLOGICAL: bevacizumab|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microsatellite Instability in Colorectal Cancers
Status: COMPLETED
Conditions: Colorectal Cancer|Colorectal Carcinoma|Microsatellite Instability High|Microsatellite Instability Low|Microsatellite Instability-High
Interventions: DIAGNOSTIC_TEST: Microsatellite instability analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dynamo: a Tailored Lifestyle Promotion Intervention Among Pediatric Patients With Cardiometabolic Risk Factors
Status: RECRUITING
Conditions: Obese
Interventions: BEHAVIORAL: Sensor based PA intervention|BEHAVIORAL: Traditional PA counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Erdafitinib Monotherapy or in Combination With Cetrelimab in Muscle-invasive Bladder Cancer Patients With Fibroblast Growth Factor Receptor (FGFR ) Gene Alterations
Status: RECRUITING
Conditions: Muscle-invasive Bladder Cancer
Interventions: DRUG: Erdafitinib monotherapy|DRUG: Cetrelimab and Erdafitinib combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CDP323 Biomarker Study
Status: COMPLETED
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: CDP323|DRUG: CDP323|DRUG: CDP323|DRUG: CDP323|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Expanding Phase III Study of Tyroserleutide for Injection
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Gan Fu Le Tablets|DRUG: Tyroserleutide for injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Memantine Treatment in Fragile X-Associated Tremor/Ataxia Syndrome
Status: COMPLETED
Conditions: Fragile X-Associated Tremor/Ataxia Syndrome|Fragile X Premutation Carriers
Interventions: DRUG: Memantine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Precision of Complete-arch Digital Implant Impressions With Intraoral Scanning Versus Photogrammetry
Status: COMPLETED
Conditions: Edentulous Jaw
Interventions: OTHER: Digital scanning|OTHER: Photogrammetry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maternal Mental Health Trial
Status: RECRUITING
Conditions: Major Depressive Disorder|Postpartum Depression
Interventions: DRUG: Transdermal patch estradiol|DRUG: Transdermal patch placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of β-carotene Biofortified Maize in Reducing Vitamin A Deficiency Among Children
Status: COMPLETED
Conditions: Vitamin A Deficiency|Low Serum Retinol
Interventions: DIETARY_SUPPLEMENT: β-Carotene Biofortified Maize Flour|DIETARY_SUPPLEMENT: White Maize Flour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Two Point Discrimination
Status: UNKNOWN
Conditions: Ehlers-Danlos Syndrome (EDS)|Complex Regional Pain Syndrome (CRPS)|Amplified Musculoskeletal Pain Syndrome (AMPS)|Low Back Pain|Fibromyalgia|Chronic Widespread Pain
Interventions: BEHAVIORAL: Two-point discrimination training|BEHAVIORAL: One-point discrimination training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Pulse-synchronized Negative Pressure on the Dermal Microcirculation
Status: TERMINATED
Conditions: Microcirculation|Diabetes
Interventions: DEVICE: pulse-synchronized negative pressure (PSNP) device|OTHER: Control - no intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Decision Aids on the Participation of South Asian Women in Cervical Cancer Screening
Status: NOT_YET_RECRUITING
Conditions: Cervical Cancer
Interventions: BEHAVIORAL: printed screening decision aid|BEHAVIORAL: a leaftlet|BEHAVIORAL: mobile screening decision aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Vaginal Dinoprostone Administration Prior to Insertion Levonorgestrel-releasing Intrauterine System in Women With no Previous Vaginal Delivery
Status: COMPLETED
Conditions: Intrauterine Device
Interventions: DRUG: Dinoprostone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of "Operating Table Position Simulating Radiographs" on Acetabular Cup Angle During Primary Total Hip Replacement
Status: COMPLETED
Conditions: Hip Osteoarthritis
Interventions: OTHER: radiograph
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Incretin Action in Physiology and Diabetes
Status: COMPLETED
Conditions: Insulin Secretion
Interventions: DRUG: GIP infusion|DRUG: GLP-1 infusion|DRUG: Ex-9 infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in Vivo)
Status: RECRUITING
Conditions: Chronic Migraine
Interventions: DEVICE: HD-tDCS Active Protocol|DEVICE: HD-tDCS Sham Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aprepitant Versus Gabapentin Prophylaxis for Postoperative Nausea and Vomiting in Laparoscopic Gynecological Surgeries
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: dexamethasone|DRUG: Gabapentin|DRUG: Aprepitant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acupuncture vs TENS for Gag Reflex
Status: COMPLETED
Conditions: Gagging
Interventions: PROCEDURE: Acupuncture|DEVICE: TENS|DEVICE: Sham-TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of Belcesiran in Patients With AATLD
Status: TERMINATED
Conditions: Alpha 1-Antitrypsin Deficiency
Interventions: DRUG: Belcesiran|OTHER: Placebo|DRUG: Belcesiran|OTHER: Placebo|DRUG: Belcesiran|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Erector Spinae Plane Block For Postoperative Analgesia in Patients Undergoing Total Abdominal Hysterectomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Erector Spinae Plane Block|PROCEDURE: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Local Cold Application and ShotBlocker Use in Subcutaneous Injection on Injection Pain and Patient Satisfaction
Status: COMPLETED
Conditions: Pain|Satisfaction, Patient
Interventions: OTHER: shotblocker|OTHER: local cold application|OTHER: ShotBlocker placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of PolyHeme(R) in Hemorrhagic Shock Following Traumatic Injuries Beginning in the Pre-Hospital Setting
Status: UNKNOWN
Conditions: Hemorrhagic Shock
Interventions: DRUG: Poly SFH-P Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amiodarone Usage After Ischemic Ventricular Tachycardia Ablation
Status: UNKNOWN
Conditions: Ischemic Cardiomyopathy|Ventricular Tachycardia|ICD Shock
Interventions: PROCEDURE: Ventricular tachycardia ablation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MUC1-Activated T Cells for the Treatment of Relapsed and Resistant Ovarian Cancer
Status: NOT_YET_RECRUITING
Conditions: Platinum-Resistant Fallopian Tube Carcinoma|Platinum-Resistant Ovarian Carcinoma|Platinum-Resistant Primary Peritoneal Carcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Fallopian Tube Carcinosarcoma|Recurrent Female Reproductive System Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Ovarian Carcinosarcoma|Recurrent Platinum-Resistant Fallopian Tube Carcinoma|Recurrent Platinum-Resistant Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Recurrent Primary Peritoneal Carcinosarcoma|Refractory Fallopian Tube Carcinoma|Refractory Female Reproductive System Carcinoma|Refractory Ovarian Carcinoma|Refractory Primary Peritoneal Carcinoma
Interventions: BIOLOGICAL: Autologous MUC1-activated T-cells|DRUG: Bendamustine|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Cyclophosphamide|PROCEDURE: Echocardiography|PROCEDURE: Leukapheresis|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Multigated Acquisition Scan|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation for Primary Progressive Aphasia
Status: COMPLETED
Conditions: Primary Progressive Aphasia
Interventions: DEVICE: transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thymoglobulin, Sirolimus and Mycophenolate Mofetil for Prevention of Acute Graft-Versus-Host Disease (GVHD)
Status: TERMINATED
Conditions: Hematological Malignancies|Myelodysplastic Syndrome|Leukemia|Lymphoma
Interventions: DRUG: Mycophenolate Mofetil (MMF)|DRUG: Thymoglobulin|DRUG: Sirolimus|PROCEDURE: Stem Cell Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Cefepime/VNRX-5133 in Patients With Complicated Urinary Tract Infections
Status: COMPLETED
Conditions: Urinary Tract Infections|Acute Pyelonephritis
Interventions: DRUG: Cefepime/VNRX-5133 (taniborbactam)|DRUG: Meropenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Fatty Acids Supplementation in ADHD
Status: TERMINATED
Conditions: ADHD
Interventions: DIETARY_SUPPLEMENT: Omega-3 Fatty Acids Supplementation|DIETARY_SUPPLEMENT: Omega-3 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Tocilizumab + Methotrexate on Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tocilizumab [RoActemra/Actemra]|DRUG: tocilizumab [RoActemra/Actemra]|DRUG: Placebo|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Th Effect of Ketogenic Metabolic Nutritional Pattern on High-frequency Episodic Migraine (EMIKETO)
Status: UNKNOWN
Conditions: Migraine|Ketogenic Dieting|Weight Loss|Overweight|Brain Diseases
Interventions: DIETARY_SUPPLEMENT: very-low-calorie-ketogenic-diet|OTHER: hypocaloric-balanced-diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: RCT Comparing Invisalign and Traditional Orthodontic Treatment
Status: COMPLETED
Conditions: Malocclusion, Angle Class II
Interventions: OTHER: Aligners|OTHER: Clear braces
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cediranib Maleate and Olaparib in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Peritoneal Cancer or Recurrent Triple-Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Fallopian Tube Carcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian High Grade Serous Adenocarcinoma|Ovarian Serous Adenocarcinoma|Ovarian Serous Surface Papillary Adenocarcinoma|Primary Peritoneal Serous Adenocarcinoma|Triple-Negative Breast Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Cediranib Maleate|PROCEDURE: Computed Tomography|PROCEDURE: Echocardiography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Multigated Acquisition Scan|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Ocular Surface Squamous Neoplasia Surgical Excision in People Living With HIV in Sub-Saharan Africa
Status: RECRUITING
Conditions: Ocular Surface Squamous Neoplasia|HPV
Interventions: PROCEDURE: Surgical
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Gliatiline® on Post-stroke Patients With Vascular Cognitive Impairment no Dementia
Status: COMPLETED
Conditions: Cognitive Impairment|Stroke
Interventions: DRUG: choline alfoscerate|DRUG: placebo (for choline alphoscerate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficiency of Luspatercept in Chinese Adults With Transfusion Dependent β-thalassemia: a Real-world Study
Status: UNKNOWN
Conditions: Thalassemia Major|Transfusion-dependent Anemia
Interventions: DRUG: Luspatercept Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HCQ for Primary Prophylaxis Against COVID19 in Health-care Workers
Status: WITHDRAWN
Conditions: Sars-CoV2|Infection Viral|Healthcare Worker|Prophylaxis
Interventions: DRUG: Hydroxychloroquine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Virtual Phone Visits Compared to In-Person Physical Visits for Post-Operative Follow-Up at a Sports Medicine Clinic
Status: COMPLETED
Conditions: Patient Satisfaction|Sports Injury|Surgery|Orthopedic Disorder
Interventions: OTHER: virtual phone appointment visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate Fatigue in Participants With Relapsing Remitting Multiple Sclerosis When Treated With Dimethyl Fumarate
Status: WITHDRAWN
Conditions: Relapsing-Remitting Multiple Sclerosis|Multiple Sclerosis
Interventions: DRUG: dimethyl fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Fish Oil and Colesevelam (STAIR7007)
Status: UNKNOWN
Conditions: Sitosterolemia
Interventions: DRUG: Colesevelam|DIETARY_SUPPLEMENT: Fish Oil|DRUG: Combination of fish oil and colesevelam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Acceptability, Feasibility and Safety of a Yoga Program for Chronic Pain in Sickle Cell Disease
Status: TERMINATED
Conditions: Sickle Cell Disease
Interventions: BEHAVIORAL: Part A Survey|BEHAVIORAL: Part B Yoga Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Exercise Intensity on Fitness, Extracellular Vesicles, Inflammation, and Metabolism
Status: RECRUITING
Conditions: Exercise Training
Interventions: OTHER: Control Group|OTHER: Moderate Intensity Continuous Training|OTHER: Heavy Intensity Continuous Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Everolimus in de Novo Kidney Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: Everolimus|DRUG: Mycophenolate sodium|DRUG: Cyclosporine|DRUG: Steroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PROVIGIL® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy or Obstructive Sleep Apnea/Hypopnea Syndrome
Status: COMPLETED
Conditions: Narcolepsy|Sleep Apnea, Obstructive
Interventions: DRUG: Modafinil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Therapy for Voice Hearing (VR-VOICES): a Randomized Controlled Trial
Status: RECRUITING
Conditions: Hallucinations, Verbal Auditory
Interventions: BEHAVIORAL: VR-VOICES|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Melatonin Supplementation on Renal Physiology in a Habitual Sleep Restricted Population.
Status: TERMINATED
Conditions: Obesity|Prediabetic State
Interventions: DRUG: Melatonin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Docetaxel, Cisplatin, and S-1 (TPS) Induction Chemotherapy in Locally Advanced Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: S-1|DRUG: S-1|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Effectiveness of Osteopathic Manipulative Treatment in Chronic Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: OTHER: osteopathic manipulative treatment|OTHER: sham treatment|DRUG: triptans
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study and Pilot RCT Into the Use of a Novel Technology to Train Sitting Balance and Trunk Control
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: T-Chair 2.0 Prototype|OTHER: General Rehabilitation Programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute and Chronic Effects of Avena Sativa on Cognition and Stress
Status: COMPLETED
Conditions: Cognitive Change|Stress, Psychological|Mood
Interventions: DIETARY_SUPPLEMENT: Avena sativa|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Anti-Reflux Endoscopic TX Using APC (AREA) in GERD Patients: (The AREA Study)
Status: RECRUITING
Conditions: Gastro Esophageal Reflux
Interventions: PROCEDURE: ARAT|PROCEDURE: Sham intervention (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Polyetheretherketone vs Cobalt-chromium Telescopic Removable Partial Denture in Kennedy Class I Patients Regarding Oral Health Related Quality of Life
Status: UNKNOWN
Conditions: Partially Edentulous Mandible
Interventions: DEVICE: peek telescopic partial denture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NanO2 for Large Vessel Occlusion Stroke
Status: NOT_YET_RECRUITING
Conditions: Ischemic Stroke
Interventions: OTHER: Placebo|BIOLOGICAL: dodecafluoropentane emulsion (DDFPe)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ranibizumab for the Treatment of Choroidal Neovascularisation (CNV) Secondary to Pathological Myopia (PM): an Individualized Regimen
Status: COMPLETED
Conditions: Choroidal Neovascularisation
Interventions: DRUG: ranibizumab 0.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic of Everolimus and Atorvastatin Co-administration
Status: COMPLETED
Conditions: Difference of 12-hour AUC
Interventions: DRUG: Atorvastatin 20 mg|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Hand-Arm Bimanual Intensive Training (HABIT) in Children With Bilateral Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: HABIT|OTHER: Conventional Occupational Therapy (OT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Deciphering the Interactions Between Food Intake, Sleepiness, and Nighttime Sleep Quality in Patients With Type 1 Narcolepsy and Idiopathic Hypersomnia
Status: NOT_YET_RECRUITING
Conditions: Narcolepsy Type 1|Idiopathic Hypersomnia
Interventions: BEHAVIORAL: Monitoring of eating behaviors|BEHAVIORAL: Monitoring of sleep/wake rhythm|BEHAVIORAL: Measure of nocturnal sleep parameters|BEHAVIORAL: Measure of sleepiness
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multisensory Early Oral Administration of Human Milk in Preterm Infants
Status: RECRUITING
Conditions: Infant Development|Stress
Interventions: PROCEDURE: Multisensory Early Oral Administration of Human Milk (M-MILK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-blind, Controlled Study to Evaluate the Safety and Feasibility of a Intraoral Electrotherapy Device
Status: UNKNOWN
Conditions: Periodontal Diseases
Interventions: DEVICE: a noninvasive intraoral electrotherapy device|DEVICE: a sham device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Induced Hypertension for Acute Ischemic Stroke
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DRUG: intravenous saline|DRUG: intravenous phenylephrine|DRUG: intravenous levophed|DRUG: oral midodrine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cisplatin Chemoradiation With or Without Cetuximab for Locoregionally Advanced Squamous Cell Carcinomas (SCC) of the Head and Neck
Status: UNKNOWN
Conditions: Head and Neck Neoplasms|AJCC Stage III/IV
Interventions: OTHER: Chemoradiation plus Cetuximab|OTHER: Chemoradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Evaluate Ear Acupressure Effects in Treating Seasonal Allergic Rhinitis
Status: TERMINATED
Conditions: Seasonal Allergic Rhinitis
Interventions: DEVICE: acupressure pellets|DEVICE: acupressure pellets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of General and Non-general Anesthesia on Perioperative Depression or Anxiety
Status: COMPLETED
Conditions: Depression, Anxiety
Interventions: PROCEDURE: anesthesia approach (general anesthesia or non-general anesthesia)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Doxorubicin Hydrochloride Liposome Injection in Subjects With Ovarian Cancer.
Status: COMPLETED
Conditions: Ovarian Cancer Recurrent
Interventions: DRUG: Doxorubicin Hydrochloride Liposome Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Simple Hysterectomy in Low Risk Cervical Cancer
Status: NOT_YET_RECRUITING
Conditions: Cervical Cancer|Cervix Cancer
Interventions: PROCEDURE: Minimally invasive simple hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Denosumab vs Placebo in Patients With Thalassemia Major and Osteoporosis
Status: COMPLETED
Conditions: Thalassemia Major|Osteoporosis
Interventions: DRUG: Denosumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Endocrine Therapy, Palbociclib, Avelumab in Estrogen Receptor Positive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Avelumab|DRUG: Endocrine therapy|DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Keratinocyte Growth Factor to Prevent Acute GVHD
Status: COMPLETED
Conditions: Graft-vs-Host Disease
Interventions: DRUG: Recombinant Human Keratinocyte Growth Factor (rHuKGF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Validation of Universal Scale in Oral Surgery (USOS) for Patient's Psycho-emotional Status Rating
Status: COMPLETED
Conditions: Fear, Dental
Interventions: DIAGNOSTIC_TEST: Pre-operative USOS scale testing|DIAGNOSTIC_TEST: Pre-operative SDPQ, MDAS and VAS testing|DIAGNOSTIC_TEST: Post-operative doctor's reported USOS|DIAGNOSTIC_TEST: Re-testing 4-6 weeks later
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Follow-up Study of GSK Biologicals' Human Papilloma Virus (HPV) Vaccine to Prevent Cervical Infection in Young Adults
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: BIOLOGICAL: HPV 16/18 VLP AS04
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Body Weight Supported Treadmill Training On Balance In Stroke Patients
Status: COMPLETED
Conditions: Cerebrovascular Stroke|Cerebral Stroke|Cerebrovascular Accident
Interventions: OTHER: Body Weight Supported Treadmill Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Effectiveness, Safety and Quality of Life Measures With Hydromorphone HCL, Dilaudid CR (Controlled Release)
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Osteoarthritis, Hip
Interventions: DRUG: OROS hydromorphone HCL ; OxyContin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Clinical Trial of BAT4306F on Safety, Tolerability and Pharmacokinetics for Patients
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: BIOLOGICAL: 500mg BAT4306F|BIOLOGICAL: 750mg BAT4306F|BIOLOGICAL: 900mg BAT4306F|BIOLOGICAL: 1000mg BAT4306F
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Pentoxifylline on Anemia in Hemodialysis Patients
Status: NOT_YET_RECRUITING
Conditions: Hemodialysis Complication
Interventions: DRUG: pentoxifylline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Primary Birmingham Hip Resurfacing Arthroplasty Using a Metal-on-Metal Couple in the Young Active Patient
Status: COMPLETED
Conditions: Indications for a Total Hip Prosthesis
Interventions: DEVICE: Primary Birmingham hip resurfacing arthroplasty using a metal-on-metal couple
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tongue Conservation Surgery for Oral Tongue Cancer
Status: TERMINATED
Conditions: Tongue Cancer|Chemotherapy Effect|Surgery
Interventions: DRUG: Induction chemotherapy|PROCEDURE: Tongue conservation surgery|RADIATION: postoperative CCRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT