pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Neuromodulation in Patients With Painful Chronic Pancreatitis
Status: COMPLETED
Conditions: Painful Chronic Pancreatitis|Visceral Pain|Neuropathic Pain
Interventions: DEVICE: GammaCore Device|DEVICE: Sham Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TVB 2640 for Resectable Colon Cancer Other Resectable Cancers; a Window Trial.
Status: RECRUITING
Conditions: Colon Cancer
Interventions: DRUG: TVB-2640|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Prophylactic Use of Silymarin on Hepatotoxicity Induced by Anti-tuberculosis Drugs
Status: UNKNOWN
Conditions: Tuberculosis
Interventions: DRUG: Silymarin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Blinded Randomized Trial of Anticoagulation to Prevent Ischemic Stroke and Neurocognitive Impairment in AF
Status: TERMINATED
Conditions: ATRIAL FIBRILLATION
Interventions: DRUG: Rivaroxaban|OTHER: standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optimization of Golimumab Treatment in Ulcerative Colitis
Status: UNKNOWN
Conditions: Colitis, Ulcerative
Interventions: DRUG: Golimumab 50 mg in patients <80 kg and Golimumab 100 mg in patients >80 kg|DRUG: Golimumab treatment optimization.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Ambulatory Oxygen on the Walking Test in Patients With Pulmonary Fibrosis
Status: COMPLETED
Conditions: Pulmonary Fibrosis
Interventions: DRUG: oxygen|DRUG: medical air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of Implant Fixation and SF-36 for Short Hip-Stems - A Prospective Clinical Study
Status: COMPLETED
Conditions: Primary and Secondary Coxarthrosis|Dysplasia Coxarthrosis|Post-traumatic Necrosis of the Femoral Head
Interventions: DEVICE: Total Hip Arthroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Group-based Positive Psychotherapy in Psychological Resilience of Only-Child-Lost People
Status: COMPLETED
Conditions: Resilience, Psychological|Bereavement|Mental Health
Interventions: BEHAVIORAL: Positive Psychotherapy|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Psilocybin-assisted Therapy for Treatment of Alcohol Use Disorder
Status: RECRUITING
Conditions: Alcohol Use Disorder
Interventions: DRUG: Psilocybin|DRUG: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of Multiple Doses of COR-001
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: COR-001|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bowen Technique and Post Isometric Relaxation in Knee Osteoarthritis Patients
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Bowen Technique|OTHER: Post Isometric Relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modular Cognitive Behavioral Therapy for the Treatment of Child Anxiety Disorders in Elementary School Settings
Status: COMPLETED
Conditions: Separation Anxiety Disorder|Generalized Anxiety Disorder|Social Phobia
Interventions: BEHAVIORAL: cognitive behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Clopid® (Clopidogrel) 75 mg Tablet and Plavix® 75 mg Tablet After Oral Administration to Healthy Adult Subjects Under Fasting Condition
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Clopid® 75 mg Tablet|DRUG: Plavix® 75mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Peripherally Inserted Versus Centrally Inserted Central Venous Catheters in the Neurological Intensive Care
Status: COMPLETED
Conditions: Venous Thrombosis
Interventions: PROCEDURE: Central venous catheter|PROCEDURE: Central venous catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pinaverium and Herbs for Irritable Bowel Syndrome Treatment: an Onset and Offset Study (PHIBEST)
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Pinaverium|DEVICE: Atractylodes|DEVICE: Paeonia Lactiflora|DEVICE: Tangerine Peel|DRUG: Ledebouriella Root|DRUG: Radix codonopsitis|DRUG: Radix curcumae|DRUG: Fingered citron|DRUG: Tuckahoe|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Atorvastatin v. Placebo on HCC Risk
Status: RECRUITING
Conditions: Liver Fibroses|Cirrhosis
Interventions: DRUG: Atorvastatin 20mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Muscle Afferent Feedback During Exercise in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Fentanyl|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study Comparing Two Standard of Care Adjuvant Chemotherapy Regimens for Lower Risk HER-2 Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: TC-H x Paclitaxel (P) + Trastuzumab(T)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effects of Topical Low Dose Preservative-free Hydrocortisone on Intraocular Pressure
Status: COMPLETED
Conditions: Ocular Surface Disease|Glaucoma
Interventions: DRUG: Hydrocortisone (CORTIVIS ®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) to Exclude Lesions Linked to Significant Traumatic Brain Injuries
Status: NOT_YET_RECRUITING
Conditions: Traumatic Brain Injury
Interventions: OTHER: UCH-L1 GFAP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reduction of Corneal Astigmatism With Toric Intraocular Lens Implantation in Congenital Cataract
Status: COMPLETED
Conditions: Congenital Cataract
Interventions: DEVICE: Acrysof Toric IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Polymorphisms in the Adenosine a2a Receptor Gene and AMPD2 Gene on Adenosine-Induced Vasodilation and Reactive Hyperemia
Status: COMPLETED
Conditions: Blood Flow in Healthy Volunteers
Interventions: DRUG: Intra-arterial infusion of adenosine|DRUG: intra-arterial infusion of caffeine|DRUG: intra-arterial infusion of acetylcholine|DRUG: intra-arterial infusion of sodium nitroprusside|PROCEDURE: Occlusion of arm-circulation by inflation of upper-arm cuff to 200mmHg for 2, 5 and 13 minutes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Negative Pressure Applied by the Equinox MPD for Severe Open Angle Glaucoma
Status: COMPLETED
Conditions: Glaucoma, Open-Angle
Interventions: DEVICE: Negative Pressure Treatment via the Mercury Multi-Pressure Dial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: NSAIDs in Sciatica NSAIDS IN SCIATICA
Status: COMPLETED
Conditions: Sciatica
Interventions: DRUG: Naproxen 500 Mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Patient Perceptions Undergoing Manual Cataract Surgery (MCS) vs Refractive Laser-assisted Cataract Surgery (ReLACS) in First and Second Eyes
Status: COMPLETED
Conditions: MCS vs ReLACS|Pain Perception Postoperatively First Eye vs Second Eye|Early Anesthesia vs Standard Anesthesia
Interventions: PROCEDURE: MCS|PROCEDURE: ReLACS Early|PROCEDURE: ReLACS Standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Taxane and Taxane-Induced Peripheral Neuropathy in African American Patients With Stage I-III Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Invasive Breast Carcinoma|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8
Interventions: DRUG: Docetaxel|DRUG: Paclitaxel|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of ONC201 for Refractory Meningioma
Status: NOT_YET_RECRUITING
Conditions: Meningioma|Refractory Meningioma|Relapsed Meningioma
Interventions: DRUG: ONC201
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of PF-06410293 (Adalimumab-Pfizer) And Adalimumab (Humira) In Healthy Subjects (REFLECTIONS B538-07))
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: BIOLOGICAL: PF-06410293|BIOLOGICAL: Adalimumab-US|BIOLOGICAL: Adalimumab-EU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Puesta Mesylate Combined With Pomalidomide Capsules and Low-dose Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma
Status: NOT_YET_RECRUITING
Conditions: Relapsed or Refractory Multiple Myeloma (RRMM)
Interventions: DRUG: Purinostat Mesylate 3mg/m2|DRUG: Purinostat Mesylate 4 mg/m2|DRUG: Purinostat Mesylate 6 mg/m2|DRUG: Purinostat Mesylate 8.4 mg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Methocarbamol in Ventral and Inguinal HR
Status: RECRUITING
Conditions: Ventral Hernia|Inguinal Hernia
Interventions: DRUG: Methocarbamol|DRUG: Standard Opioid|DRUG: Standard opioid plus methocarbamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers of Neuroinflammation and Anti-Inflammatory Treatments in Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Minocycline|DRUG: Placebo|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dose Finding Study of a DNA Vaccine Delivered With Intradermal Electroporation in Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: pVAXrcPSAv53l (DNA encoding rhesus PSA)|DEVICE: DERMA VAX™ intradermal DNA delivery system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multidisciplinary Team Approach: Working Together to Improve Glycemic Control in Hispanic Adults Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: OTHER: Specialized multidisciplinary diabetes team (SMDT) approach|OTHER: Traditional model of care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Cytoreductive Surgery and Hyperthermic Intrathoracic Pleural Chemotherapy (HITC) With Escalating Doses for Children and Adolescents With Unilateral Pleural Malignancy
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Cisplatin|DRUG: Amifostine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long-term Study of DE-117 Ophthalmic Solution Monotherapy and Concomitant Use of DE-117 Ophthalmic Solution With Timolol Ophthalmic Solution in Patients With OAG or OH: RENGE Study
Status: COMPLETED
Conditions: Open Angle Glaucoma or Ocular Hypertension
Interventions: DRUG: DE-117 ophthalmic solution|DRUG: Timolol ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics and Preliminary Efficacy Study of CFZ533 in Patients With Primary Sjögren's Syndrome
Status: COMPLETED
Conditions: Primary Sjögren's Syndrome
Interventions: DRUG: CFZ533 active - Cohort 1|DRUG: CFZ533 placebo- Cohort 1|DRUG: CFZ533 active - Cohort 2|DRUG: CFZ533 placebo - Cohort 2|DRUG: CFZ533 active -Cohort 3|DRUG: CFZ533 active - Cohort 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: E-training of Inmate Peer Caregivers for Enhancing Geriatric and End-of-life Care in Prisons
Status: ENROLLING_BY_INVITATION
Conditions: Aging
Interventions: BEHAVIORAL: Inmates Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Fresh Corneal Lenticule Implantation in Macular Corneal Distrophy With Relex Smile Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Macular Corneal Dystrophy
Interventions: PROCEDURE: Fresh Corneal Lenticule Implantation using Relex-Smile Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Follow-up Study of Safety of Enteric-coated Mycophenolate Sodium in Patients Who Successfully Completed Study CERL080A301
Status: COMPLETED
Conditions: Renal Transplant
Interventions: DRUG: Mycophenolate sodium (enteric coated)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Lidocaine After Major Arthroscopic Knee Surgery
Status: COMPLETED
Conditions: Fracture of Patella|Pain
Interventions: PROCEDURE: Sham operation|PROCEDURE: Knee arthroscopic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stellest Lenses and Low-concentration Atropine Myopia Control Among Children
Status: RECRUITING
Conditions: Myopia
Interventions: DEVICE: Stellest Lenses|COMBINATION_PRODUCT: Stellest Lenses+0.05% atropine|DRUG: Single vision Lenses+0.05% atropine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Inorganic Nitrite Delivery to Improve Exercise Capacity in HFpEF
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Nebulized Sodium Nitrite|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Pluripotent Stem Cell-derived Mesenchymal Stem Cell Exosome (PSC-MSC-Exo) Eye Drops Treatment for Dry Eye Diseases Post Refractive Surgery and Associated With Blepharospasm
Status: NOT_YET_RECRUITING
Conditions: Dry Eye Disease
Interventions: DRUG: Pluripotent Stem Cell-derived Mesenchymal Stem Cell Exosome (PSC-MSC-Exo) Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of QD Versus BID Silodosin With Lower Urinary Tract Symptoms Suggestive of BPH
Status: COMPLETED
Conditions: Benign Prostatic Hypertrophy
Interventions: DRUG: Silodosin|DRUG: Silodosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BMS-214662 Plus Trastuzumab in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: BMS-214662|BIOLOGICAL: trastuzumab|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HydroCoil Cerebral Aneurysm Treatment Trial
Status: TERMINATED
Conditions: Intracerebral Aneursym
Interventions: DEVICE: MicroVention Hydrogel coil|DEVICE: Non-hydrogel coils
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Followed by Stem Cell Transplant in High-risk Neuroblastoma Patients
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: DRUG: Cycles N8, N5 and N6|DRUG: Cycles N5 and N6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intensified Physical Activity for Patients With Stroke - a Combined Physical and Behavioural Approach
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: High-Intensity Functional Exercise Programmes (HIFE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Simvastatin on Breast Cancer Cell Growth in Women With Stage I-II Breast Cancer
Status: COMPLETED
Conditions: Invasive Breast Carcinoma|Stage I Breast Cancer AJCC v7|Stage IA Breast Cancer AJCC v7|Stage IB Breast Cancer AJCC v7|Stage II Breast Cancer AJCC v6 and v7|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Diaphragm and Abdominal Muscle Training on PFT and Dyspnea Among COPD Obstructive Pulmonary Disease Patients.
Status: NOT_YET_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: • Diaphragmatic breathing technique|OTHER: basic breathing technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Aggressive Versus Conservative Blood Glucose Control in Hospitalized Type 2 Diabetic Patients Using Detemir and Aspart Insulin
Status: WITHDRAWN
Conditions: Type 2 Diabetes
Interventions: DRUG: Levemir (Detemir) and Novolog (Aspart) Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/Phase 2 Open-label Study to Evaluate the Safety, Tolerability, and Efficacy of a Single Intravenous Administration of SAR444836 in Adult Participants With Phenylketonuria
Status: RECRUITING
Conditions: Phenylketonuria
Interventions: DRUG: SAR444836
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Tuberculosis in Prisons
Status: TERMINATED
Conditions: Tuberculosis, Pulmonary|Antibiotic Prophylaxis
Interventions: DRUG: Isoniazid 900 milligrams|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of CD07805/47 Gel in Rosacea Flushing
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: CD07805/47, CD07805/47+Placebo, Placebo, CD07805/47, Placebo|DRUG: Placebo, CD07805/47+Placebo, CD07805/47, CD07805/47, Placebo|DRUG: CD07805/47, CD07805/47+Placebo, Placebo, Placebo, CD07805/47|DRUG: Placebo, CD07805/47+Placebo, CD07805/47, Placebo, CD07805/47
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer
Status: RECRUITING
Conditions: Metastatic HER2-positive Breast Cancer
Interventions: DRUG: Zanidatamab|DRUG: Trastuzumab|DRUG: Eribulin|DRUG: Vinorelbine|DRUG: Gemcitabine|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The IRMI-FMT Trial
Status: TERMINATED
Conditions: Fecal Microbiota Transplantation|Malignant Melanoma Stage III|Malignant Melanoma Stage IV
Interventions: PROCEDURE: Allogenic Fecal Microbiota Transplantation|PROCEDURE: Autologous Fecal Microbiota Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Elective Lymph Node Treatment Versus Clinical Observation in the Absence of Palpable Lymph Nodes for High Risk Skin Squamous Cell Carcinoma (SCC)
Status: TERMINATED
Conditions: High Risk Cutaneous Squamous Cell Carcinoma
Interventions: PROCEDURE: elective lymph node dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Association Between Systemic Microvascular Endothelial Function and Coronary Physiology Indexes
Status: COMPLETED
Conditions: Myocardial Ischemia
Interventions: DIAGNOSTIC_TEST: Coronary angiography with physiological lesion assessment by fractional flow reserve (FFR) and contrast fractional flow reserve (cFFR).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Umbilical Cord Mesenchymal Stem Cells Therapy for Diabetic Nephropathy
Status: UNKNOWN
Conditions: Mesenchymal Stem Cells|Diabetic Nephropathy
Interventions: DRUG: Human umbilical cord mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DC-CIK In Combination With Chemotherapy ( Gio / Oxaliplatin or Cisplatin ) Versus First-line Chemotherapy for Locally Advanced Unresectable or Metastatic Gastric Adenocarcinoma Randomized Controlled Phase II Clinical Study of Treatment
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: BIOLOGICAL: autologous dendritic cells co-cultured with cytokine-induced killer cells|DRUG: Gimeracil and Oteracil Porassium Capsules|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of Ziprasidone for the Treatment of Acute Exacerbation of Schizophrenia or Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Ziprasidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Plant-based Diets in Hemodialysis Patients
Status: WITHDRAWN
Conditions: Renal Disease
Interventions: DIETARY_SUPPLEMENT: Standard Diet|DIETARY_SUPPLEMENT: Low-k|DIETARY_SUPPLEMENT: Standard
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Effect of Wismemo on Alzheimer's Dementia Patients
Status: WITHDRAWN
Conditions: Alzheimer Disease
Interventions: DIETARY_SUPPLEMENT: Wismemo|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Compare SB15 (Proposed Aflibercept Biosimilar) to Eylea in Subjects With Neovascular Age-related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: SB15 (Proposed aflibercept biosimilar)|DRUG: Eylea (Aflibercept)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cryoablation, Radiofrequency Ablation, or Microwave Ablation in Treating Patients With Metastatic Sarcoma Stable on Chemotherapy
Status: TERMINATED
Conditions: Osteosarcoma|Sarcoma
Interventions: DEVICE: Microwave ablation|DEVICE: Cryoablation|DEVICE: Radiofrequency ablation|OTHER: BPI-Short form|OTHER: FACT-G7
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide and Rituximab in Treating Patients With Recurrent and/or Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: rituximab|DRUG: lenalidomide|GENETIC: microarray analysis|OTHER: flow cytometry|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of a Hybrid Fractional Laser for the Treatment of Acne Scars in Patients With Skin of Color
Status: RECRUITING
Conditions: Acne Scars - Mixed Atrophic and Hypertrophic|Hyperpigmentation|Laser-Induced Hyperpigmentation
Interventions: DEVICE: Sciton Halo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Double-masked Study of VVN539 in Subjects With Elevated Intraocular Pressure
Status: COMPLETED
Conditions: Glaucoma, Open-Angle
Interventions: DRUG: VVN539 Ophthalmic Solution 0.02%|DRUG: VVN539 Ophthalmic Solution 0.04%|DRUG: VVN539 Ophthalmic Solution Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Preoperative Caldolor Decrease the Requirement for Postoperative Narcotics
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Intravenous Ibuprofen|OTHER: IV Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acetyl-L-Carnitine Reduces Depression and Improves Quality of Life in Patients With Minimal Hepatic Encephalopathy
Status: COMPLETED
Conditions: Minimal Hepatic Encephalopathy
Interventions: DRUG: Acetyl-L-Carnitine|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy
Status: RECRUITING
Conditions: Suicidal Ideation|Major Depressive Disorder|Schizo Affective Disorder|Bipolar Disorder
Interventions: DEVICE: Sigma-Stim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modified Hip Capsular Incision: an Easier Way to do Hip Capsulorrhaphy in Developmental Dysplasia of the Hip (DDH)
Status: RECRUITING
Conditions: Developmental Hip Dysplasia
Interventions: PROCEDURE: Modified hip capsular incision
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Glass Ionomer Cement Modified With Chlorhexidine and Titanium Dioxide in Primary Molars (RCT)
Status: COMPLETED
Conditions: Dental Caries in Children
Interventions: OTHER: glass ionomer-chlorhexidine|OTHER: glass ionomer-titanium dioxide powder|OTHER: glass ionomer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rural Smoking Cessation
Status: NOT_YET_RECRUITING
Conditions: Smoking Cessation
Interventions: DRUG: Nicoderm CQ nicotine patch|DRUG: Nicorette Nicotine Lozenges
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Successful Spinal Needle Placement Between Crossed Leg Sitting Position and Traditional Sitting Position
Status: COMPLETED
Conditions: Adult Patients With Spinal Anesthesia
Interventions: PROCEDURE: Cross leg sitting position|PROCEDURE: Traditional sitting position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Acupuncture for Lumbar Spinal Stenosis
Status: UNKNOWN
Conditions: Lumbar Spinal Stenosis|Intermittent Claudication
Interventions: OTHER: Acupuncture|OTHER: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Low Back Pain. Topical Diclofenac and Oral Ibuprofen.
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: Ibuprofen 400 mg|DRUG: Topical diclofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liver Transplantation With Two-stage Liver Resection in Unresectable Liver Cancer , Metastases or Emd-stage Liver Disease (LTLR-LC)
Status: NOT_YET_RECRUITING
Conditions: Liver Transplant Disorder|Hepatic Cancer|End-stage Liver Disease
Interventions: PROCEDURE: assisted liver transplantation combined with two-stage hepatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Chemotherapy in High Risk Stage II Colon Cancer
Status: NOT_YET_RECRUITING
Conditions: Stage II Colon Cancer|Adjuvant Chemotherapy
Interventions: DRUG: FOLFOX/XELOX/Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Telmisartan Fixed Dose Combination vs Amlodipine in Hypertensive Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan 80|DRUG: Amlodipine 10|DRUG: Amlodipine 10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Bupivacaine Alone vs Bupivacaine and Dexmed in Cesarean Deliveries
Status: UNKNOWN
Conditions: Dexmedetomidine
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Pharmacokinetics, Safety, and Efficacy of Glecaprevir/Pibrentasvir in Pediatric Subjects With Genotypes 1-6 Chronic Hepatitis C Virus (HCV) Infection
Status: COMPLETED
Conditions: Hepatitis C Virus (HCV)
Interventions: DRUG: Glecaprevir/Pibrentasvir Adult Formulation|DRUG: Glecaprevir + Pibrentasvir Pediatric Formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect at 6 Months of Renal Denervation in Chronic Heart Failure d'Insuffisance Cardiaque
Status: UNKNOWN
Conditions: Chronic Heart Failure
Interventions: DEVICE: EnligHTN™ Renal Denervation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telmisartan Versus Enalapril in Heart Failure With Reduced Ejection Fraction Patients With Moderately Impaired Kidney Functions
Status: COMPLETED
Conditions: Heart Failure With Reduced Ejection Fraction|Renal Insufficiency
Interventions: DRUG: Telmisartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zanubrutinib Combined With Tislelizumab in the Treatment of r/r PMBCL and EBV+ DLBCL
Status: UNKNOWN
Conditions: Primary Mediastinal Large B Cell Lymphoma|EBV-Positive DLBCL, Nos
Interventions: DRUG: Zanubrutinib|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IM19 CAR-T Cell Therapy in Refractory Systemic Lupus Erythematosus (SLE)
Status: NOT_YET_RECRUITING
Conditions: Refractory Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: IM19 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Clinical Study of Apatinib and SHR-1210 in Treating Advanced Hepatocellular Carcinoma or Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer|Hepatocellular Carcinoma
Interventions: DRUG: apatinib|DRUG: SHR-1210
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Unicondylar Knee Arthroplasty Versus Total Knee Arthroplasty in Patients With Anteromedial Osteoarthritis of the Knee
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis
Interventions: PROCEDURE: Total knee arthroplasty|PROCEDURE: Unicompartment knee arthroplasty|DEVICE: Persona|DEVICE: Oxford
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Informed Movement for People With Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: OTHER: pain informed movement|OTHER: standard neuromuscular exercise|OTHER: Pain Neuroscience Education (PNE)|OTHER: Standard osteoarthritis (OA) education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Polydatin Injectable (HW6) for Shock Treatment
Status: UNKNOWN
Conditions: Shock, Hemorrhagic|Shock, Traumatic|Shock, Septic
Interventions: DRUG: Polydatin Injectable
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-Inferiority Trial of TrIGR for PTSD
Status: RECRUITING
Conditions: PTSD
Interventions: BEHAVIORAL: Trauma Informed Guilt Reduction Therapy|BEHAVIORAL: Cognitive Processing Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Aclidinium Bromide 400 µg Compared to Placebo and to Tiotropium Bromide in Patients With Stable Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Aclidinium bromide|DRUG: Tiotropium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Mitoxantrone Hydrochloride Liposome Injection in Patients With Advanced Pancreatic Cancer
Status: UNKNOWN
Conditions: Advanced Pancreatic Cancer
Interventions: DRUG: Mitoxantrone Hydrochloride Liposome injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MITIGATE-NeoBOM: A Study to Evaluate 68Ga- NeoBOMB1 in Patients With Advanced TKI-treated GIST Using PET/CT
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumors
Interventions: DRUG: 68Ga-NeoBOMB1, 2-vial kit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Virtual Reality at End-of-life
Status: RECRUITING
Conditions: End of Life|Pain|Nausea|Fatigue|Well-Being, Psychological|Depression|Dyspnea|Appetite Loss|Anxiety
Interventions: BEHAVIORAL: Personalized virtual reality experience
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Y- Shaped Pegylated Interferon (YPEG-IFNα-2a) Plus Ribavirin in Egyptian Patients With Untreated Chronic Hepatitis C
Status: UNKNOWN
Conditions: Self Efficacy|Hepatitis C
Interventions: DRUG: pegylated interferon alpha 2a YPEG-IFN α-2a 180mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare the Efficacy of VItrectomy Combined With DExamethasone Implant Versus With Aflibercept in DME Patients Diagnosed by Intraoperative OCT (the VIDEO Study): Study Protocol for a Randomized Controlled Trial
Status: RECRUITING
Conditions: Diabetic Macular Edema|Pars Plana Vitrectomy|Dexamethasone Intravitreal Implant|Intraoperative Optical Coherence Tomography
Interventions: DRUG: Ozurdex|DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Co-administration of Pramlintide and Insulin Via an Automated Dual-hormone Artificial Pancreas System in Adults With Type 1 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1|Type 1 Diabetes|Postprandial Hyperglycemia
Interventions: DRUG: Rapid-Acting Insulin|DRUG: Placebo|DRUG: Pramlintide Acetate|DEVICE: Artificial Pancreas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Almonertinib Combined With Pyrotinib in the Treatment of Advanced NSCLC Patients With HER-2 Amplification/Mutation After EGFR-TKI Resistance
Status: UNKNOWN
Conditions: Safety
Interventions: DRUG: Almonertinib combine with Pyrrolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Polyphenol Supplementation on Hepatic Steatosis and Vascular Compliance
Status: RECRUITING
Conditions: Obesity, Childhood|Hepatic Steatosis|Intimal Hyperplasia
Interventions: DIETARY_SUPPLEMENT: Effect of polyphenols on hepatic steatosis and vascular elastography and intima media thickness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Non-randomized Study to Evaluate the Safety and Performance of the NovaCross™ Microcatheter in Femoropopliteal Chronic Total Occlusion (CTO).
Status: COMPLETED
Conditions: Chronic Total Occlusion
Interventions: DEVICE: NovaCross™ microcatheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: (CARE Network Trial - Treating Children to Prevent Exacerbations of Asthma (TREXA)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Beclomethasone dipropionate|DRUG: Beclomethasone dipropionate|DRUG: Albuterol sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treating PCOS With Semaglutide vs Active Lifestyle Intervention
Status: ACTIVE_NOT_RECRUITING
Conditions: PCOS|Adolescent Obesity|NAFLD
Interventions: DRUG: Semaglutide 3mg and 7mg [Rybelsus]|OTHER: Weight loss diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photo Neuro-Modulation Therapy to Adults
Status: UNKNOWN
Conditions: Photo Neuro-Modulation Therapy, Mild Cognitive Impairment
Interventions: DEVICE: Photoneuromodulation therapy|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Tetrathiomolybdate in Combination With Carboplatin/Pemetrexed in Metastatic Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Tetrathiomolybdate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BLI800-480: A Safety and Efficacy Evaluation of 2 Different Bowel Cleansing Preparations in Adult Subjects
Status: COMPLETED
Conditions: Colonoscopy|Bowel Preparation|Endoscopy
Interventions: DRUG: SUPREP Bowel Prep Kit|DRUG: FDA approved bowel preparation containing electrolytes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognition and Magnetic Resonance Imaging of Brain Inflammation in Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: PROCEDURE: Oral glucose tolerance test|BEHAVIORAL: Cognitive testing|PROCEDURE: Magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Low Remifentanil Target Controlled Infusions for Cardiac Surgery
Status: COMPLETED
Conditions: Cardiac Surgery
Interventions: DRUG: Ce 1 ng/ml|DRUG: Ce 2 ng/ml|DRUG: Ce 3 ng/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ipilimumab and Sargramostim in Treating Patients With Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Recurrent Prostate Carcinoma|Stage IV Prostate Cancer AJCC v7
Interventions: BIOLOGICAL: Ipilimumab|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|BIOLOGICAL: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabetes Risk Reduction Through Eat, Walk, Sleep and Medication Therapy Management for Depressed Cambodians
Status: COMPLETED
Conditions: Diabetes|Depression
Interventions: BEHAVIORAL: Social Services|BEHAVIORAL: Lifestyle|BEHAVIORAL: Lifestyle Plus Medication Therapy Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Liposomal Bupivacaine Versus 0.25% Bupivacaine for Laparoscopic Urologic Surgery
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Bupivacaine|DRUG: liposomal bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neural Conduction Along the Visual Pathways After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases
Status: COMPLETED
Conditions: Glaucoma|Optic Neuropathy, Ischemic|Visual Pathway Disorder|Optic Nerve|Neural Conduction
Interventions: DRUG: Citicoline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of On-line Hemodiafiltratrion on Nutritional Status and Body Composition
Status: COMPLETED
Conditions: Chronic Kidney Disease Requiring Chronic Dialysis
Interventions: DEVICE: High-flux hemodialysis|DEVICE: On line-hemodiafiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of IL-11 in DDAVP Unresponsive
Status: COMPLETED
Conditions: Hemophilia A|Von Willebrand Disease
Interventions: BIOLOGICAL: Neumega (Oprelvekin, Interleukin 11, IL-11)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Weifuchun Treatment on Precancerous Lesions of Gastric Cancer
Status: UNKNOWN
Conditions: Chronic Atrophic Gastritis With Hyperplasia (Diagnosis)
Interventions: DRUG: Weifuchun
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT