pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Concurrent Bupropion / Varenicline for Smoking Cessation
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: DRUG: Varenicline|DRUG: Bupropion|DRUG: Nicotine patches|DRUG: Nicotine Inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Opioid vs. Opioid-free Anesthesia for Hip Arthroscopy
Status: TERMINATED
Conditions: Opioid Free Anaesthesia|Postoperative Analgesia
Interventions: DRUG: Lidocaine/ ketamine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Investigate the Effects of an Infant Formula Containing Partially Hydrolysed Proteins on Growth, Safety and Tolerance in Healthy Term Infants
Status: COMPLETED
Conditions: Growth
Interventions: OTHER: Infant Formula with prebiotics|OTHER: Standard Infant Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Platelet Rich Plasma and Perineural Injection Therapy for Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: OTHER: platelet rich plasma|OTHER: 5% dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility of Paired Vagus Nerve Stimulation With Rehabilitation for Improving Upper Extremity Function in People With Cervical Spinal Cord Injury
Status: RECRUITING
Conditions: Cervical Spinal Cord Injury
Interventions: DEVICE: Active VNS|DEVICE: Sham VNS|OTHER: Arm rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Two Paraffin Wax Chewing Gums of Different Consistency on the Stimulated Saliva Flow Rate
Status: COMPLETED
Conditions: Xerostomia
Interventions: DIAGNOSTIC_TEST: Paraffin Pellets from Aurosan GmbH|DIAGNOSTIC_TEST: Chewing wax from the Saliva-Check Buffer from GC Europe
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: HAIC Combined With Cadonilimab and Bevacizumab as First-line Therapy in Unresectable Hepatocellular Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Unrescetable Hepatocellular Carcinoma
Interventions: DRUG: HAIC+Cadonilimab+Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S-1 for 9 Months Versus 1 Year for Stage II Gastric Cancer (SMAC）
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: S-1 for 9 months|DRUG: S-1 for 1 year
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Tripterygium Wilfordii Gel for Moderate Activity Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Topical tripterygium gel|DRUG: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ME-609 and Acyclovir for Treatment of Herpes Simplex Labialis in Immunocompromised Patients
Status: COMPLETED
Conditions: Herpes Labialis
Interventions: DRUG: ME-609|DRUG: Acyclovir in ME-609 vehicle (5% acyclovir)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Mindfulness Based Elder Care (MBEC) on Psychological and Spiritual Well Being
Status: COMPLETED
Conditions: Mental Health Issue
Interventions: BEHAVIORAL: the mindfulness-based elder care (MBEC) therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intraoperative EEG Monitoring and Postoperative Delirium in Elderly Patients With Sevoflurane Anesthesia
Status: COMPLETED
Conditions: Postoperative Delirium|Sevoflurane|Electroencephalogram
Interventions: DRUG: Low MAC|DRUG: High MAC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 104 Week Clinical Trial Comparing Long Term Glycaemic Control of Insulin Degludec/Liraglutide (IDegLira) Versus Insulin Glargine Therapy in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec/liraglutide|DRUG: insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: School-based Asthma Care for Teens (SB-ACT)
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: School-Based Asthma Care for Teens (SB-ACT)|BEHAVIORAL: Directly Observed Therapy|BEHAVIORAL: Asthma Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase III Clinical Trial to Evaluate the Efficacy and Safety of DP-R208 and Each Monotherapy
Status: COMPLETED
Conditions: Hypertension|Cholesterolemia
Interventions: DRUG: DP-R208|DRUG: Candesartan32mg|DRUG: Rosuvastatin 20mg|DRUG: DP-R208 Placebo|DRUG: Candesartan32mg Placebo|DRUG: Rosuvastatin 20mg Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ancillary Procedures in Patients of Refractory Facial Palsy Patients Selection and Evaluation of the Outcomes
Status: UNKNOWN
Conditions: Facial Palsy
Interventions: PROCEDURE: Botox and brow lift|PROCEDURE: Injection|PROCEDURE: Suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Spironolactone on Calcineurin Inhibitor Induced Nephrotoxicity
Status: COMPLETED
Conditions: Disorder Related to Renal Transplantation
Interventions: DRUG: Spironolactone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety, Tolerability, and PK of Fulvestrant After IM Administration
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Fulvestrant for Injectable Suspension|DRUG: Faslodex (Reference)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Randomized Controlled Trials of the Effects of Decadron on Swallowing, Airway, and Arthrodesis
Status: UNKNOWN
Conditions: Swallowing
Interventions: DRUG: Decadron|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Decision Aid About Statin Use in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus|Dyslipidemia|Hypercholesterolemia|Cardiovascular Disease
Interventions: DEVICE: Decision Aid Statin Choice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose:
Clinical trial: Comparing the Gastric Transit of Commercial Milk and A2 Milk
Status: COMPLETED
Conditions: Lactose Intolerance, Adult Type
Interventions: OTHER: Milk containing A1 and A2 beta-casein|OTHER: Milk containing only A2 beta-casein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Assessment of Adductor Canal Blockade in Anterior Cruciate Ligament Surgery
Status: UNKNOWN
Conditions: Surgery of Arthroscopic Anterior Cruciate Ligament Repair
Interventions: DRUG: Analgesic nerve blockade (Ropivacaine)|PROCEDURE: Arthroscopic surgical repair of the anterior cruciate ligament
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multisegmented Foot Motion in Patients With Lateral Ankle Sprains and Chronic Ankle Instability
Status: UNKNOWN
Conditions: Injuries, Ankle|Sprain of Foot
Interventions: OTHER: Intrinsic Foot Strengthening|OTHER: Joint Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Cluster-randomized Cross-over Trial Evaluating the Comparative Effectiveness of Three Skin Antiseptic Interventions
Status: COMPLETED
Conditions: Bacteremia
Interventions: DRUG: Iodine tincture|DRUG: Chlorhexidine gluconate|DRUG: Povidone iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prostate Radiotherapy Comparing Moderate and Extreme Hypo-fractionation (PRIME Trial)
Status: RECRUITING
Conditions: Prostate Adenocarcinoma
Interventions: RADIATION: Moderate Hypo-fractionation|RADIATION: Extreme Hypo-fractionation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Entecavir and Pegasys Sequential Therapy Versus Pegasys for HBeAg Negative Chronic Hepatitis B
Status: UNKNOWN
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Entecavir and peginterferon (Pegasys) (52 weeks)|DRUG: Peginterferon (Pegasys) (96 weeks)|DRUG: Peginterferon (Pegasys) (48 weeks)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computer Guided Modified Ridge Splitting Versus Free Hand Technique in Horizontal Deficiency in Posterior Mandible
Status: NOT_YET_RECRUITING
Conditions: Horizontal Bone Augmentation|Horizontal Ridge Deficiency
Interventions: PROCEDURE: computer guided modified ridge splitting technique in horizontal bone deficiency in posterior mandible|PROCEDURE: free hand modified ridge splitting technique in horizontal bone deficiency in posterior mandible
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Levobupivacaine and Levobupivacaine With Dexmedetomidine in Ultrasound Guided Pectoral Nerve Block
Status: TERMINATED
Conditions: Breast Cancer|Mastectomy, Modified Radical
Interventions: DRUG: Levobupivacaine|DRUG: Levobupivacaine + Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Early Detection of Vulval CAncer Through Self-Examination (EDuCATE): Intervention Study
Status: COMPLETED
Conditions: Self-Examination|Vulvar Cancer|Vulvar Lichen Sclerosus|Vulval Intraepithelial Neoplasia|Vulval Cancer|Vulval Intraepithelial Neoplasia With Lichen Sclerosus|Lichen Planus
Interventions: BEHAVIORAL: Training in Vulval Self-Examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of ABT-267 in Treatment Naive Hepatitis C Virus (HCV) Genotype 1 Infected Subjects
Status: COMPLETED
Conditions: Chronic Hepatitis C|Hepatitis C Virus (HCV) Infection
Interventions: DRUG: ABT-267|DRUG: Pegylated interferon (pegIFN)|DRUG: Ribavirin (RBV)|OTHER: Placebo for ABT-267
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Postoperative Functional Recovery and Analgesic Efficacy of a Single Shot Sciatic Nerve Block Versus Posterior Capsule/Fat Pad Infiltration of Local Anesthetic for Total Knee Arthroplasty
Status: COMPLETED
Conditions: Total Knee Arthroplasty|Post Operative Analgesia
Interventions: PROCEDURE: Sciatic Nerve Block|PROCEDURE: Posterior capsule infiltration with local anesthetic|PROCEDURE: Sham sciatic block and sham posterior infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Placebo-Controlled Onset-of-Action Study of Flurbiprofen Utilizing the Double-Stopwatch Method
Status: COMPLETED
Conditions: Acute Pharyngitis|Sore Throat
Interventions: DRUG: flurbiprofen|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Amphetamine Extended Release Tablets and Driving Performance in Subjects With Attention Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: Amphetamine Extended Release (ER) Tablet 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of MK-0873 Following Patch Application in Healthy Participants and Psoriasis Participants (MK-0873-020)
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: MK-0873 Patch|DRUG: MK-0873 Cream|DRUG: Placebo Patch|DRUG: Placebo Cream|DRUG: Plain patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Natural Food on Gut Microbiome and Phospholipid Spectrum of Immune Cells in COVID-19 Patients
Status: RECRUITING
Conditions: COVID-19
Interventions: DIETARY_SUPPLEMENT: Freeze-dried Mare Milk (Saumal)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Optive Versus Systane Concomitant With Restasis (Cyclosporine A) for the Treatment of Dry Eye Symptoms
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Systane, Optive, Restasis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vegetarian Ketogenic Diet VS Omnivore Ketogenic Diet - Protocol of a Keto-vege Diet for Remission of Type 2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus Type 2 in Obese|Hypertension|Diabetes Mellitus Type 2 With Hyperglycemia|Inflammation|Dysbiosis
Interventions: OTHER: Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Trial to Evaluate the Effect of Diet and Exercise in Renal Transplant Recipients on Tacrolimus
Status: COMPLETED
Conditions: Renal Transplantion|Kidney Transplantion
Interventions: DRUG: Tacrolimus With Diet and Exercise Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Examining the Effectiveness of the myPlan App to Prevent Dating Violence With Adolescents
Status: COMPLETED
Conditions: Intimate Partner Violence
Interventions: BEHAVIORAL: Personalized Healthy Relationship and Safety Planning Tool|BEHAVIORAL: Usual Care Teen Relationship and Health Website
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Efficacy of Acupuncture in Refractory Irritable Bowel Syndrome
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome
Interventions: OTHER: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Heart Failure With Preserved Ejection Fraction With Qishen Granules
Status: RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: Qishen Granules|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Acupuncture and Moxibustion Treatment in Patients With Active Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease|CAM
Interventions: OTHER: Treatment Group|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Bevacizumab and Triamcinolone in Treatment or Macular Edema Secondary to CRVO
Status: TERMINATED
Conditions: Macular Edema|Central Retinal Vein Occlusion
Interventions: DRUG: bevacizumab and triamcinolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK Study of Telmisartan/Rosuvastatin FDC Compared to Combination of Telmisartan and Rosuvastatin
Status: COMPLETED
Conditions: Dyslipidemia & Hypertension
Interventions: DRUG: Crestor 20mg(Rosuvastatin 20mg), Micardis 80mg(Telmisartan 80mg) , FDC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A First in Human Study to Evaluate Safety, Tolerability, and Pharmacology of PF-06826647 in Healthy Subjects and Subjects With Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: PF-06826647 tablet|DRUG: PF-06826647 oral suspension|OTHER: Placebo oral solution/suspension|OTHER: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Eicosapentaenoic Acid on Subjects at High Risk for Colorectal Cancer
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DIETARY_SUPPLEMENT: Eicosapentaenoic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pentoxifylline as Adjunctive Therapy in Patients With Ulcerative Colitis
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases
Interventions: DRUG: Pentoxifylline 400 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: High vs. Standard Dose Flu Vaccine in Adult Stem Cell Transplant Recipients
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematopoietic Cell Transplantation
Interventions: BIOLOGICAL: Quadrivalent Inactivated Influenza Vaccine|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Trivalent Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Efficacy and Safety of Racecadotril in Children Aged 3 to 60 Months Suffering From Acute Diarrhea
Status: COMPLETED
Conditions: Diarrhea, Infantile
Interventions: DRUG: Racecadotril plus ORS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Interaction Between ACT-246475 and Clopidogrel, Prasugrel, and Ticagrelor in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ACT-246475|DRUG: Clopidogrel|DRUG: Prasugrel|DRUG: Placebo|DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Monitoring Local Tissue Oxygen Changes Using the Wireless Lumee Oxygen Platform in Correlation to TcPO2
Status: UNKNOWN
Conditions: Peripheral Artery Disease
Interventions: DEVICE: Wireless Lumee Oxygen Platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: NKG2D-based CAR T-cells Immunotherapy for Patient With r/r NKG2DL+ Solid Tumors
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma|Glioblastoma|Medulloblastoma|Colon Cancer
Interventions: BIOLOGICAL: NKG2D-based CAR T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Losartan in Patients With Nonobstructive Hypertrophic Cardiomyopathy
Status: COMPLETED
Conditions: Hypertrophic Cardiomyopathy
Interventions: DRUG: losartan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Alcohol Elimination Effect of TCI711 Probiotic (Bacillus Coagulans) on Adult Individuals
Status: COMPLETED
Conditions: Breath Alcohol Level
Interventions: DIETARY_SUPPLEMENT: Bacillus coagulans TCI711
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial of LONSURF in Recurrent/Metastatic Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Metastatic Nasopharyngeal Carcinoma|Recurrent Nasopharyngeal Carcinoma
Interventions: DRUG: TAS-102
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of L-ornithine L-aspartate and Therapeutic Plasma Exchange Versus Plasma Exchange Alone in Lowering Ammonia and Improving Outcomes in Pediatric Acute Liver Failure.
Status: NOT_YET_RECRUITING
Conditions: Liver Failure, Acute
Interventions: DRUG: L-ornithine L-Aspartate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: LCL161 in Treating Patients With Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocytosis Myelofibrosis
Status: COMPLETED
Conditions: Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase|Primary Myelofibrosis|Secondary Myelofibrosis
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration|DRUG: Smac Mimetic LCL161
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center Randomized Double-Blind Placebo-Controlled Study To Investigate the Effect of Isoprinosine in Immunodepressed Patients With Uncomplicated Generalized Lymphadenopathy
Status: COMPLETED
Conditions: Lymphatic Disease|HIV Infections
Interventions: DRUG: Inosine pranobex
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Quality of Life for Children With Zirconium Anteroir Crowns Versus Strip Composite Crowns
Status: COMPLETED
Conditions: Caries
Interventions: OTHER: Zirconium crowns|OTHER: Strip composite crowns
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pancreatic Adenocarcinoma Neoadjuvant Chemotherapy Before Surgery
Status: RECRUITING
Conditions: Pancreatic Adenocarcinoma
Interventions: DRUG: mFOLFIRINOX|DRUG: Gemcitabine / Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rosuvastatin/Ezetimibe vs Rosuvastatin in Korean Patients With Type 2 Diabetes Mellitus and Hypercholesterolemia
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Hypercholesterolemia
Interventions: DRUG: Rosuvamibe® Tab|DRUG: Monorova® Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of INS365 Ophthalmic Solution in a Controlled Adverse Environment in Patients With Dry Eye
Status: COMPLETED
Conditions: Keratoconjunctivitis Sicca
Interventions: DRUG: INS365 Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine on Prevention of Side Effects of Hemabate
Status: UNKNOWN
Conditions: Gynecological Patient
Interventions: DRUG: placebo|DRUG: low dose dexmedetomidine|DRUG: high dose dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ascending Glycan Dietary Supplementation in Healthy Adults
Status: RECRUITING
Conditions: Healthy Individuals
Interventions: DIETARY_SUPPLEMENT: Monosaccharide Powder|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cardiac Index, SVR/SVRI During Weaning From ECC- Data Obtained From Femoral and Radial Artery Transducer
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease|Aortic Valve Disease|Mitral Valve Disease
Interventions: DEVICE: CO/CI/SVR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Epidemiology and Pathophysiological Mechanisms of HTAP in SS and SC Children in Martinique and Guadeloupe.
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: OTHER: HTAP/ clinical complications in the sickle cell disease
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Triple Antigen vs Monoantigen Immunotherapy for Warts
Status: COMPLETED
Conditions: Triple Intralesional Immunotherapy Combination in Multiple Recalcitrant Warts
Interventions: BIOLOGICAL: Intralesional antigen immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nutritional Strategies After Muscle Strain Injuries
Status: ACTIVE_NOT_RECRUITING
Conditions: Muscle Strain, Multiple Sites
Interventions: DIETARY_SUPPLEMENT: Protein supplementation|DIETARY_SUPPLEMENT: Carbohydrate supplementation|PROCEDURE: Active rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of SZC and Enhanced Nutrition Advice Compared to SoC in Dialysis Patients With Hyperkalaemia
Status: TERMINATED
Conditions: Hyperkalaemia
Interventions: DRUG: Sodium Zirconium Cyclosilicate (SZC)|OTHER: Enhanced dietary advice|OTHER: Standard dietary advice including K+ restriction.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Autologous Cultivated Limbal Stem Cells Transplantation (ACLSCT) for Restoration of Corneal Epithelium in Patients With Limbal Stem Cell Deficiency
Status: COMPLETED
Conditions: Limbal Stem Cells Deficiency
Interventions: PROCEDURE: Biopsy from donor eye|PROCEDURE: Implant of Holoclar|PROCEDURE: Ophtalmologic examination|PROCEDURE: Blood sample collection|PROCEDURE: Digital pictures|PROCEDURE: ECG|BEHAVIORAL: Questionnaires|PROCEDURE: Physical examination and vital signs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Busulfan and FLAG Conditioning Regimen for Allogeneic Peripheral Blood Stem Cell Transplantation
Status: UNKNOWN
Conditions: Leukemia
Interventions: DRUG: Busulfan (Zhejiang Otsuka Pharmaceutical Co. Ltd)|DRUG: Cytarabine(Actavis Italy S.p.A)|DRUG: Fludarabine (Bayer)|DRUG: granulocyte colony-stimulating factor (KirinKunpeng)|DRUG: rabbit ATG（Sanofi/Genzyme）
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuroinflammation in Asymptomatic Carotid Artery Disease - Imaging Substudy
Status: RECRUITING
Conditions: Critical Asymptomatic Carotid Artery Disease|Non-Critical Asymptomatic Carotid Artery Disease
Interventions: DRUG: [18F]DPA-714
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: To Evaluate the Effect of Inhaled Medication Together With Exercise and Activity Training on Exercise Capacity and Daily Activities in Patients With Chronic Lung Disease With Obstruction of Airways
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: placebo to tiotropium + olodaterol|DRUG: tiotropium+olodaterol|DRUG: tiotropium +olodaterol|DRUG: tiotropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Radiotherapy and Durvalumab in DLBCL and FL
Status: COMPLETED
Conditions: Diffuse Large B Cell Lymphoma|Follicular Lymphoma
Interventions: DRUG: Durvalumab|RADIATION: Radiotherapy|RADIATION: Radiotherapy (cohort 6 only)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Exercise Training in Hypertrophic Cardiomyopathy
Status: COMPLETED
Conditions: Cardiomyopathy, Hypertrophic
Interventions: BEHAVIORAL: Exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Ozenoxacin 1% Cream Versus Placebo in the Treatment of Patients With Impetigo
Status: COMPLETED
Conditions: Impetigo
Interventions: DRUG: ozenoxacin placebo|DRUG: retapamulin 1% ointment|DRUG: ozenoxacin 1% cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Patient Education Videos on Perioperative Anxiety in Patients Undergoing Endoscopic Sinus Surgery
Status: COMPLETED
Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: OTHER: Video Education|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis
Status: RECRUITING
Conditions: Atherosclerotic Cardiovascular Disease|End Stage Kidney Disease
Interventions: DRUG: CSL300|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Aerobic and Isokinetic Exercise in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: OTHER: 'aerobic exercise'|DEVICE: 'isokinetic exercise'
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety, Tolerability, and Immunogenicity of a Clostridium Difficile Toxoid Vaccine in Healthy Elderly Volunteers
Status: COMPLETED
Conditions: Clostridium Infections
Interventions: BIOLOGICAL: Vaccine diluent buffer (Placebo)|BIOLOGICAL: C. difficile toxoid vaccine (2 µg)|BIOLOGICAL: C. difficile toxoid vaccine (10 µg)|BIOLOGICAL: C. difficile toxoid vaccine (50 µg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Tucatinib on Cardiac Repolarization in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: tucatinib|DRUG: placebo|DRUG: moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic of Mefloquine-Artesunate in Plasmodium Falciparum Malaria Infection in Pregnancy
Status: COMPLETED
Conditions: Plasmodium Falciparum Malaria
Interventions: DRUG: Mefloquine-artesunate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Posterior Ocular Changes Between Singleton Pregnancy and Multifetal Pregnancy.
Status: UNKNOWN
Conditions: Twin Pregnancy, Antepartum Condition or Complication|Retinal Vascular|Choroidal Effusion
Interventions: DEVICE: Corneal tomography, optical coherence tomography and optical coherence tomography angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Early Retinal Nerve Injury in Type 2 Diabetes Patients Without Diabetic Retinopathy
Status: UNKNOWN
Conditions: Diabetes Mellitus|Diabetic Retinopathy|Nerve Injury
Interventions: DEVICE: routine ophthalmic examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Expert Arbitration on Clinical Outcomes When Disputes Over Diagnosis Arise Between Physicians and Their Artificial Intelligence Counterparts: a Randomized, Multicenter Trial in Pediatric Outpatients
Status: UNKNOWN
Conditions: Pediatric Outpatients Encountered in Three Specialty Clinics, i.e. Respirology, Gastroenterology, and Genito-urology
Interventions: OTHER: expert arbitration over discordant diagnoses made by AI diagnostic system and human doctors, respectively
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Corneal Collagen Cross-Linking for Ectasia (CXL)
Status: COMPLETED
Conditions: Ectasia
Interventions: DRUG: riboflavin ophthalmic solution|DEVICE: UVA Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Vitamin D on Inflammation in Liver Disease
Status: UNKNOWN
Conditions: Hepatitis C Infection|Vitamin D Deficiency
Interventions: DRUG: Vitamin D|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Docetaxel in Treating Women With Locally Advanced or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Recurrent Breast Cancer|Stage IV Breast Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: docetaxel|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iowa/Nucleus 10/10 mm and Nucleus Freedom Feasibility Study
Status: COMPLETED
Conditions: Hearing Loss, Sensorineural|Hearing Loss, Bilateral
Interventions: DEVICE: Iowa/Nucleus 10/10 mm and Freedom Cochlear Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Doxorubicin and Avastin® in Sarcoma.
Status: TERMINATED
Conditions: Sarcoma|Soft Tissue Sarcoma
Interventions: DRUG: Avastin|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dacomitinib + Pemetrexed for Patients With Advanced Non-squamous Non-small Cell Lung Cancer (NSCLC)
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Dacomitinib, Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Exercise, Endocannabinoids and Ketones on Cerebral Metabolism in a Cognitive Disorders Population
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson Disease|Alzheimer Disease
Interventions: DIETARY_SUPPLEMENT: Betaquik MCT supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ibalizumab Plus Optimized Background Regimen in Treatment-Experienced Patients With Multi-Drug Resistant HIV-1
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: ibalizumab|DRUG: Optimized Background Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simvastatin + Cetuximab/Irinotecan in K-ras Mutant Colorectal Cancer (CRC)
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: cetuximab/irinotecan/simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Application of 18F-PEG3-FPN PET Imaging in Diagnosis and Staging of Malignant Melanoma
Status: UNKNOWN
Conditions: Melanoma
Interventions: DRUG: 18F-PEG3-FPN
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: FIT and Fecal Calprotectin in Patients With Chronic Lower GI Symptoms
Status: COMPLETED
Conditions: Colorectal Cancer|Colorectal Adenoma|Colitis
Interventions: DIAGNOSTIC_TEST: Fecal calprotectin|DIAGNOSTIC_TEST: Fecal immunochemical test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 3 Study of Cysteamine Bitartrate Delayed-release (RP103) Compared to Cystagon® in Patients With Cystinosis
Status: COMPLETED
Conditions: Cystinosis
Interventions: DRUG: Cystagon® (Cysteamine Bitartrate)|DRUG: Cysteamine Bitartrate Delayed-release Capsules (RP103)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of the Efficacy of TENS Versus Placebo in Isolated Primary Enuresis
Status: RECRUITING
Conditions: Enuresis, Nocturnal
Interventions: OTHER: TENS|OTHER: TENS Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Radiation Therapy, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients With Locally Advanced Squamous Cell Cancer of the Vulva
Status: UNKNOWN
Conditions: Stage III Vulvar Cancer AJCC v7|Stage IIIA Vulvar Cancer AJCC v7|Stage IIIB Vulvar Cancer AJCC v7|Stage IIIC Vulvar Cancer AJCC v7|Stage IVA Vulvar Cancer AJCC v7|Vulvar Squamous Cell Carcinoma
Interventions: DRUG: Cisplatin|DRUG: Gemcitabine Hydrochloride|RADIATION: Intensity-Modulated Radiation Therapy|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Investigate the Long-term Safety and Tolerability, Efficacy, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of ARGX-117 in Adults With Multifocal Motor Neuropathy
Status: ENROLLING_BY_INVITATION
Conditions: Multifocal Motor Neuropathy (MMN)
Interventions: BIOLOGICAL: ARGX-117|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Heart Rate Variability and Anxiety During Urinary Bladder Catheterization
Status: RECRUITING
Conditions: Spinal Cord Injuries|Urinary Bladder, Neurogenic|Anxiety State|Catheter Complications|Autonomic Dysreflexia
Interventions: PROCEDURE: Self-catheterization|PROCEDURE: Catheterization performed by urology nurse, participant blinded to time of procedure|PROCEDURE: Catheterization performed by urology nurse, participant aware of time of procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Durability and Impact of the Seasonal Influenza Vaccine on H5 Induced B Cell Response
Status: COMPLETED
Conditions: Influenza A Subtype H5N1 Infection
Interventions: BIOLOGICAL: Seasonal Influenza Vaccine|BIOLOGICAL: Seasonal Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Robotic-arm Assisted 68 Ga PSMA PET/CT Guided Prostate Biopsy Versus MR Directed TRUS Guided Prostate Biopsy
Status: UNKNOWN
Conditions: Prostate Cancer|Prostate Neoplasm
Interventions: PROCEDURE: PSMA PET guided prostate biopsy|PROCEDURE: MRI directed TRUS guided prostate biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of a Collaborative Intervention to Promote Employer Contact and RTW Among People With CMD or Chronic Pain
Status: RECRUITING
Conditions: Pain, Chronic|Mental Disorder
Interventions: OTHER: Demand and ability protocol|OTHER: Collaborative interventions as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Antiretroviral Drug Interaction Study in Volunteers With HIV
Status: COMPLETED
Conditions: HIV|PCP|Toxoplasmosis
Interventions: DRUG: Atovaquone 750 mg twice daily|DRUG: Atovaquone 1500 mg twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Improve Survival Among HIV-Exposed Infants in Botswana
Status: COMPLETED
Conditions: HIV Infections|Neutropenia|Anemia
Interventions: DRUG: cotrimoxazole prophylaxis|DRUG: cotrimoxazole placebo|BEHAVIORAL: exclusive breastfeeding until 6 months of age|BEHAVIORAL: breastfeeding for 12 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Management of Radiotherapy-related Xerostomia With Green Tea and Peppermint
Status: RECRUITING
Conditions: Radiation-induced Xerostomia
Interventions: DIETARY_SUPPLEMENT: mix of (green tea and peppermint)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Subcutaneous Nitroglycerin to Prevent Radial Artery Occlusion in Children
Status: RECRUITING
Conditions: Arterial Line|Ischemia
Interventions: DRUG: Nitroglycerin|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: BEMPEG With Pembrolizumab vs Pembrolizumab Alone in Patients With Metastatic or Recurrent HNSCC (PROPEL-36)
Status: TERMINATED
Conditions: Metastatic Head and Neck Cancer|Recurrent Head and Neck Cancer
Interventions: DRUG: Bempegaldesleukin|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aerobic Exercise for Primary Dysmenorrhea
Status: UNKNOWN
Conditions: Primary Dysmenorrhea
Interventions: BEHAVIORAL: High-intensity aerobic training|BEHAVIORAL: Wait-list control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral Lubrication on Appetite, Food Intake and Salivary Biomarkers in Protein Beverages
Status: COMPLETED
Conditions: Appetitive Behavior
Interventions: DIETARY_SUPPLEMENT: Unheated Whey Protein (UWP) beverage|DIETARY_SUPPLEMENT: Heated Whey Protein (HWP) beverage|DIETARY_SUPPLEMENT: Casein (Cas) beverage|DIETARY_SUPPLEMENT: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluation the Treatment Outcome for RFA in Patients With BCLC Stage B HCC in Comparison With TACE
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DEVICE: radiotherapy ablation|DEVICE: transarterial chemoembolization(TACE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Melatonin and Quality of Life in Dialysis Patients
Status: COMPLETED
Conditions: Sleep Problems|Haemodialysis
Interventions: DRUG: Melatonin tablet 3 mg once daily|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Single Oral Doses of HOPO 14-1 Evaluating Safety, Tolerability, Pharmacokinetics
Status: RECRUITING
Conditions: Toxicity;Chemical
Interventions: DRUG: HOPO 14-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Surgical Extrusion vs. Fibre Post Restoration for Crown-root Fractured Maxillary Incisors.
Status: UNKNOWN
Conditions: Fractured Tooth
Interventions: PROCEDURE: Surgical extrusion|DEVICE: Fibre post
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety and Clinical Effect of Nexagon® to Treat Persistent Epithelial Defects
Status: WITHDRAWN
Conditions: Persistent Epithelial Defect
Interventions: DRUG: Nexagon®|DRUG: Nexagon® vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT