pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of Connectivity-based rTMS and State-Dependency on Amygdala Activation
Status: COMPLETED
Conditions: Amygdala Activation
Interventions: DEVICE: repetitive transcranial magnetic stimulation|DEVICE: Sham repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess Long-Term Outcomes of Trientine in Wilson Disease Patients Withdrawn From Therapy With d-Penicillamine
Status: UNKNOWN
Conditions: Wilson Disease
Interventions: DRUG: trientine dihydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Life Support in Cardiogenic Shock
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myocardial Infarction|Cardiogenic Shock
Interventions: PROCEDURE: ECLS insertion|OTHER: Revascularisation and optimal medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Spinal Oxytocin in Healthy Volunteers
Status: TERMINATED
Conditions: Healthy Volunteer Study
Interventions: DRUG: Oxytocin 15 mcg|DRUG: Oxytocin 150 mcg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Regional Versus General Anesthesia for Promoting Independence After Hip Fracture
Status: COMPLETED
Conditions: Hip Fractures
Interventions: PROCEDURE: Regional Anesthesia|PROCEDURE: General Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mindfulness-based Intervention in Police Officers - the POLICE Study
Status: COMPLETED
Conditions: Mindfulness|Police|Quality of Life|Burnout Syndrome
Interventions: BEHAVIORAL: Mindfulness-based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Study of Biodistribution and Dosimetry of 99mTc-Glycopeptide(99mTc-GP) in Patients With Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: RADIATION: Radiolabeled (99mTc) GP (Glycopeptide)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Optimized Treatment of Peginterferon Alfa 2a/2b in Treatment Experienced Patients With HBV Related Liver Fibrosis
Status: UNKNOWN
Conditions: Hepatitis B|Liver Fibrosis
Interventions: DRUG: Tenofovir Disoproxil Fumarate|DRUG: Peginterferon Alfa-2a|DRUG: Peginterferon Alfa-2b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II/III of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Healthy Children Aged 5-11
Status: ACTIVE_NOT_RECRUITING
Conditions: Epidemic Parotitis, Mumps
Interventions: BIOLOGICAL: Attenuated Mumps vaccine (KMB-17) in phase II and III|BIOLOGICAL: Placebo in phase II|BIOLOGICAL: Attenuated Mumps vaccine (KMB-17) in phase III|BIOLOGICAL: Placebo in phase III
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Long-term Safety Study of Paricalcitol Injection in Chronic Kidney Disease Patients With Hemodialysis (HD)
Status: COMPLETED
Conditions: Secondary Hyperparathyroidism|Hemodialysis
Interventions: DRUG: Paricalcitol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Evaluating the Safety of the TQB2928 Injection Combination Therapy
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: TQB2928 Injection + Azacitidine for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Adenosine-independent Index of Coronary Artery Stenosis Severity Resting Flow Reserve
Status: TERMINATED
Conditions: Coronary; Ischemic
Interventions: DEVICE: Volcano Verrata Pressure Wire|DEVICE: St. Jude Medical (SJM) Aeris Pressure Wire System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Continuous Infusion of Local Anesthetic for Optimal Post Operative Pain Control Following Hemorrhoidectomy
Status: TERMINATED
Conditions: Hemorrhoids
Interventions: DEVICE: placement of a continuous infusion pump|DEVICE: continuous infusion pump of bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension; Renewal
Status: RECRUITING
Conditions: Liver Diseases|Portal Hypertension
Interventions: DRUG: SHAPE measurement (Sonazoid ultrasoud contrast agent)|DRUG: SHAPE measurement (Definity ultrasoud contrast agent)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Alcohol Monitor Validation
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV)
Interventions: DEVICE: Skyn Monitor Lab Session 1|DEVICE: Skyn Monitor Field Test with EMA App|DEVICE: Skyn Monitor Lab Session 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prostate Cancer, Androgen Deprivation Withdrawal and Intermittent Chemotherapy
Status: UNKNOWN
Conditions: Advanced Prostate Cancer
Interventions: DRUG: Docetaxel + LH-RH analogues|DRUG: Docetaxel|DRUG: Docetaxel|DRUG: Continuous Docetaxel|DRUG: Continuous Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Biological Therapy in Treating Patients With Acute Myelogenous Leukemia
Status: WITHDRAWN
Conditions: Leukemia
Interventions: BIOLOGICAL: recombinant interferon alfa|DRUG: amifostine trihydrate|DRUG: bromodeoxyuridine|DRUG: cytarabine|DRUG: idarubicin|DRUG: idoxuridine|DRUG: isotretinoin|DRUG: mitoxantrone hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Pivotal Bioequivalence Study Between The Sildenafil Powder For Oral Suspension (10 Mg/Ml) And The Sildenafil 10 Mg Immediate Release (IR) Tablet Relative To The Revatio 20 Mg IR Tablet In Healthy Volunteers Under Fasting Conditions
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertention
Interventions: DRUG: sildenafil citrate|DRUG: Sildenafil citrate|DRUG: sildenafil citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electroencephalography-based Precise Repetitive Transcranial Magnetic Stimulation Treatment
Status: RECRUITING
Conditions: Major Depressive Disorder (MDD)
Interventions: DEVICE: Individualized alpha frequency Transcranial Magnetic Stimulation (αTMS) Treatment|DEVICE: 10Hz-frequency TMS treatment over the left dorsolateral prefrontal cortex (DLPFC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Preoperative Gabapentin and TAP Blocks in Decreasing Postoperative Pain
Status: WITHDRAWN
Conditions: Postoperative Pain
Interventions: DRUG: Gabapentin|PROCEDURE: TAP Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: SinuSurf vs. Saline Solution in Normal Subjects
Status: COMPLETED
Conditions: Rhinosinusitis
Interventions: DRUG: SinuSurf irrigation twice daily|DRUG: NeilMed Sinus rinse irrigation twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Solitary Islet Transplantation for Type 1 Diabetes Mellitus Using Steroid Sparing Immunosuppression
Status: COMPLETED
Conditions: Diabetes Mellitus Type 1
Interventions: DRUG: Islet Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Elderly CAncer Patient: Qualitative and Quantitative Factors of Inclusion Failure in Clinical Trials
Status: COMPLETED
Conditions: Elderly|Cancer|Ethnographic Interview|Social Representation of Being Aged|Reasons of Non-participation in Clinical Trials|Qualitative Method
Interventions: OTHER: Ethnographic interview
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of the Effects of Kinesio Tape and High-intensity Laser Therapy in Lateral Epicondylitis
Status: RECRUITING
Conditions: Tennis Elbow|Physical Therapy|Kinesiotaping|Laser
Interventions: OTHER: Physiotherapy program|OTHER: Kinesio Tape|OTHER: High Intensity Laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digital Detection of Dementia (D Cubed) Studies: D3
Status: RECRUITING
Conditions: Alzheimer Disease and Related Dementias (ADRD)
Interventions: OTHER: Passive Digital Marker for screening for ADRD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Opioid Analgesic Use and Disposal Following Outpatient Dental Surgery
Status: COMPLETED
Conditions: Opioid Use Disorders|Tooth Extraction Status Nos
Interventions: BEHAVIORAL: Financial|BEHAVIORAL: Educational
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Preventive Anti-inflammatory Diet to Reduce Gastro-intestinal Inflammation in FAP Patients: a Prospective Pilot Study
Status: COMPLETED
Conditions: Familial Adenomatous Polyposis (FAP)
Interventions: DIETARY_SUPPLEMENT: Anti-inflammatory Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of DX-2930 to Prevent Acute Angioedema Attacks in Patients With Type I and Type II HAE
Status: COMPLETED
Conditions: Hereditary Angioedema (HAE)
Interventions: DRUG: DX-2930 - 300mg/2wk|DRUG: DX-2930 - 300mg/4wk|DRUG: DX-2930 - 150mg/4wk|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial
Status: RECRUITING
Conditions: Respiratory Failure|Critical Illness|Respiratory Distress Syndrome, Adult|Lung Injury|Mechanical Ventilation Complication
Interventions: PROCEDURE: Titrating sedation targeting both optimal P0.1 and appropriate arousal level|DRUG: Fentanyl|DRUG: Midazolam|DRUG: Propofol|DRUG: Dexmedetomidine|DRUG: Cisatracurium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Assessment of Ambulance Medical Service Leads to Reduced Number of Transports to the Emergency Room?
Status: UNKNOWN
Conditions: Emergency Medical Service|Assessment|Registered Nurse
Interventions: OTHER: Ambulant assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: SALpingectomy for STERilization (SALSTER)
Status: ACTIVE_NOT_RECRUITING
Conditions: Sterilization Tubal|Salpingectomy|Laparoscopy|Ovarian Reserve
Interventions: PROCEDURE: Laparoscopic tubal ligation|PROCEDURE: Laparoscopic bilateral salpingectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of a Rinse Containing Sea Salt and Lysozyme on Biofilm and Gingival Health
Status: COMPLETED
Conditions: Chronic Gingivitis|Chronic Gingivitis, Plaque Induced
Interventions: OTHER: Sea Salt Mouth Rinse|OTHER: Standardized Oral Health Practices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adjuvant Capecitabine in Elderly Patients With Breast Cancer: a Phase II Study
Status: COMPLETED
Conditions: Elderly Patients|Breast Cancer
Interventions: DRUG: Adjuvant capecitabine|DRUG: capecitabine in aduvant setting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
Status: RECRUITING
Conditions: Obstructive Hypertrophic Cardiomyopathy
Interventions: DRUG: Mavacamten|DRUG: Non-mavacamten symptomatic oHCM therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Arsenic Trioxide and Pamidronate in Treating Patients With Advanced Solid Tumors or Multiple Myeloma
Status: COMPLETED
Conditions: Refractory Multiple Myeloma|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: pamidronate disodium|DRUG: arsenic trioxide|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy and Safety for Single Dose of E004 in Children With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Epinephrine HFA-MDI (E004)|DRUG: Placebo-HFA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Of AG-013736 (Axitinib) In Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Carcinoma
Interventions: DRUG: Axitinib (AG-013736)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Postoperative Recovery Between TIVA and Inhalation Agent
Status: COMPLETED
Conditions: Enhanced Recovery After Surgery
Interventions: DRUG: total intravenous anesthesia with propofol|DRUG: inhalation anesthesia with desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacodynamic Study to Evaluate the Effect of a Fixed Dose Combination Pill on Low Density Lipoprotein (LDL) Cholesterol
Status: TERMINATED
Conditions: Elevated LDL Cholesterol
Interventions: DRUG: Cardiovascular fixed dose combination pill (acetylsalicylic acid, simvastatin and ramipril),|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Photodynamic Therapy System for Patients With Refractory/Unresponsive Solid Tumors
Status: COMPLETED
Conditions: Liver Metastasis|Pelvic Cancer|Head and Neck Cancer|Sarcoma|Rectal Cancer|Breast Cancer|Colorectal Cancer|Mouth Cancer
Interventions: DRUG: LS 11(Taporfin Sodium)|DEVICE: Lumaflex Light Delivery Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Semaglutide on Intracranial Blood Flow and Brain-Barrier Permeability in Type-2 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Stroke (CVA) or Transient Ischemic Attack
Interventions: DRUG: Semaglutide Auto-Injector|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: GUD Clinical and Virologic Response to Acyclovir in HIV Negative African Women
Status: COMPLETED
Conditions: Genital Herpes
Interventions: DRUG: acyclovir|DRUG: matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase IIb One Year Efficacy and Safety Study of S-2367 in Obese Subjects With Initial 6-Week Low Calorie Diet
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: S-2367 Placebo|DRUG: S-2367 1600 mg q.d. 54 Weeks|DRUG: S-2367 1600 mg q.d. 60 weeks|OTHER: LCD (low calorie diet)|OTHER: RCD (reduced calorie diet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lanadelumab in Participants Hospitalized With COVID-19 Pneumonia
Status: WITHDRAWN
Conditions: COVID-19 Pneumonia
Interventions: DRUG: Lanadelumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Measurement of Optical Aberrations in Hyperopia by Using an Adaptive Optics Visual Simulator (AOVIS-I)
Status: TERMINATED
Conditions: Hyperopia
Interventions: DEVICE: Monocular Adaptive Optics Visual Simulator (AOVIS-I)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Beta Blocker Therapy in Moderate to Severe COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Carvedilol|DRUG: Bisoprolol|DRUG: Beclometasone/formoterol|DRUG: Tiotropium|DRUG: Beclometasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravascular Ultrasound Prediction of Myocardial Size and Coronary Computed Tomography-Derived Ischemic Burden for Coronary Lesion
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease
Interventions: OTHER: Intravascular Ultrasound, coronary computed tomography angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ulipristal Acetate for the Preoperative Management of Hypoechoic Cellular Leiomyomas
Status: UNKNOWN
Conditions: Fibroid
Interventions: DRUG: ulipristal acetate|DRUG: Leuprolide acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Extension Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis Eczema
Interventions: DRUG: ARQ-151 Cream 0.15% or ARQ-151 Cream 0.05%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CP-675,206 Versus Either Dacarbazine Or Temozolomide In Patients Without Prior Therapy
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: dacarbazine|DRUG: CP-675,206|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Clinical Trial: Efficacy, Safety of Fecal Microbiota Transplantation for Inflammatory Bowel Disease
Status: RECRUITING
Conditions: Inflammatory Bowel Disease, Ulcerative Colitis Type
Interventions: DRUG: fecal microbiota capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myelogenous Leukemia or Acute Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: recombinant interferon alfa|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: etoposide|DRUG: idarubicin|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Downstream Molecular Signals of P2Y12 Receptors in Hyporeactive Patients Under Clopidogrel Treatment A Possible Mechanism of HOTPR(High On-Treatment Platelet Reactivity)
Status: COMPLETED
Conditions: Stable Angina
Interventions: DRUG: clopidogrel|DRUG: Placebos
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy Investigation Study of Olopatadine Hydrochloride Ophthalmic Solution Using OHIO Chamber in Patients With Seasonal Allergic Rhinitis (SAR)
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: Olopatadine 0.1%|DRUG: Tranilast 0.5%|DRUG: Placebo (Olopatadine)|DRUG: Placebo (Tranilast)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prognosis of Dental Implants in Patients With Primary Sjögren's Syndrome
Status: COMPLETED
Conditions: Dental Implant|Primary Sjögren Syndrome
Interventions: PROCEDURE: Dental implants
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics Study of MK-8189 in Participants With Schizophrenia and Healthy Participants (MK-8189-011)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: MK-8189|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Patients With PROC or r/r Adenocarcinoma NSCLC
Status: RECRUITING
Conditions: Ovarian Cancer|Non-small Cell Lung Cancer
Interventions: DRUG: TUB-040
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Additional Effects of Vagus Nerve Stimulation on Motor Functions of Upper-limb in Stroke
Status: COMPLETED
Conditions: Stroke (CVA) or TIA
Interventions: OTHER: Vagus nerve stimulation with task oriented training|OTHER: Task oriented training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Telemedicine Smoking Cessation Program in Rural Primary Care Practices
Status: COMPLETED
Conditions: Smoking
Interventions: BEHAVIORAL: Telemedicine Smoking Cessation Program|BEHAVIORAL: Telephone Quitline Smoking Cessation Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of High Flow Nasal Cannula, Standard Face Mask and Standard Nasal Cannula in Morbidly Obese Patients
Status: TERMINATED
Conditions: Desaturation of Blood|Colonoscopy
Interventions: OTHER: Salter nasal cannula|OTHER: Face mask|DEVICE: High Flow Nasal Cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Maximum Tolerated Dose (MTD) Study of INNO-206 in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Malignant Solid Tumour
Interventions: DRUG: INNO-206
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ARRx in Combination With Enzalutamide in Metastatic Castration Resistant Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: ARRx|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-Center, Randomized, Double-Masked, Placebo and Active Controlled, Dose-Ranging Evaluation of the Duration of Action of Brimonidine Tartrate Ophthalmic Solution in the Control of Ocular Redness Induced by Conjunctival Allergen Challenge (CAC)
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: Vehicle|DRUG: Brimonidine Tartrate 0.01%|DRUG: Brimonidine Tartrate 0.025%|DRUG: Oxymetazoline HCl 0.025%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)
Status: RECRUITING
Conditions: Anarthria|Dysarthria|Tetraplegia|Spinal Cord Injuries|Amyotrophic Lateral Sclerosis|Brain Stem Infarctions|Locked-in Syndrome|Muscular Dystrophies
Interventions: DEVICE: BrainGate Neural Interface System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Performance of Artificial Intelligence in Colonoscopy for Right Colon Polyp Detection
Status: COMPLETED
Conditions: Colon Cancer|Colon Polyp|Colon Lesion|Colon Adenocarcinoma
Interventions: PROCEDURE: Colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I of Biologics and Chemoradiation Therapy for Advanced Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer|Parotid Gland Cancer|Thyroid Gland Cancer|Melanoma|Stage IV Head and Neck Cancer
Interventions: DRUG: Cisplatin|DRUG: Docetaxel|DRUG: Bevacizumab|DRUG: Erlotinib|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Building Wealth and Health Network: A Microfinance/TANF Demonstration Project
Status: COMPLETED
Conditions: Hunger|Child Development|Social Isolation
Interventions: BEHAVIORAL: Self Empowerment Groups|BEHAVIORAL: Financial Empowerment|BEHAVIORAL: Matched Savings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Minimal Residual Disease in DLBCL From Cell-free Circulating DNA by NGS
Status: COMPLETED
Conditions: Non Hodgkin Lymphoma
Interventions: OTHER: next generation sequencing|DEVICE: Fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG-PET)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Oxaliplatin, Capecitabine, and Cetuximab in Treating Patients With Advanced Liver Cancer
Status: COMPLETED
Conditions: Liver Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: capecitabine|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Causal Effect of Coenzyme Q10 Nutrition and Cognitive Dysfunction in the Metabolic Storm (Hyperglycemia and Sarcopenia) and Brain-derived Neurotrophic Factor
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Alzheimer Disease|Hyperglycemia|Pre-sarcopenia
Interventions: DIETARY_SUPPLEMENT: Coenzyme Q10|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Effectiveness Study of Duloxetine HCl in Women of Different Backgrounds With Stress Urinary Incontinence Who May Also Have Other Various Medical Conditions.
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: DRUG: duloxetine HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gene Therapy With Modified Autologous Hematopoietic Stem Cells for Patients With Mucopolysaccharidosis Type IIIA
Status: ACTIVE_NOT_RECRUITING
Conditions: Mucopolysaccharidosis Type IIIA
Interventions: DRUG: Autologous CD34+ cells transduced with a lentiviral vector containing the human SGSH gene
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of CARTO 3D Mapping System Versus Conventional Method in AF and VT
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DEVICE: CARTO 3D|DEVICE: Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Phenylefrine in Prevention of Hypotension During Spinal Anesthesia for Cesarean Delivery
Status: COMPLETED
Conditions: Hypotension Drug-Induced
Interventions: DRUG: Phenylephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Deep Brain Stimulation for Idiopathic Craniofacial Dystonia: GPi or STN
Status: RECRUITING
Conditions: Craniofacial Dystonia|Deep Brain Stimulation
Interventions: DEVICE: STN-DBS|DEVICE: GPi-DBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: STOPping Versus Continuing Antiplatelet Therapy During Noncardiac Surgery and Procedures After Next Generation Drug-eluting Stent Implantation
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: DRUG: Continuing aspirin|DRUG: Stopping aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Se-Methyl-Seleno-L-Cysteine, Rituximab, Ifosfamide, Carboplatin, and Etoposide in Treating Patients With Diffuse Large B-Cell Lymphoma That Has Relapsed or Not Responded to Treatment
Status: WITHDRAWN
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: rituximab|DIETARY_SUPPLEMENT: Se-methyl-seleno-L-cysteine|DRUG: carboplatin|DRUG: etoposide|DRUG: ifosfamide|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effectiveness of Nefopam in Patients Undergoing Anterior Cervical Spine Surgery
Status: UNKNOWN
Conditions: Cervical Spine Degeneration
Interventions: DRUG: Nefopam 20 mg/ml|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-centre Failed Bowel Prep RCT
Status: COMPLETED
Conditions: Colonoscopy|Bowel Preparation
Interventions: DRUG: 4L PegLyte + 15 mg bisacodyl|DRUG: 6L PegLyte + 15 mg bisacodyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Arm Study Using the Symphony -- MRI Guided Focused Ultrasound System for the Treatment of Leiomyomas
Status: COMPLETED
Conditions: Leiomyoma|Fibroid
Interventions: DEVICE: Symphony MRI guided High Intensity Focused Ultrasound (HIFU)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Intravenous Mircera in Hemodialysis Patients With Chronic Renal Anemia
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: methoxy polyethylene glycol-epoetin beta
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study Comparing Rifampicin In A Fixed-Dose Combination (Rifampicin+Isoniazid, Myrin© 2) And The Reference Drug (Rifampicin, Rimactane®)
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: Myrin© 2 (Rifampicin + Isoniazid)|DRUG: Rimactane® (Rifampicin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Two Surgical Methods of Fixation of Subscapularis During Shoulder Arthroplasty
Status: COMPLETED
Conditions: Subscapularis Peel|Morselized Osteotomy
Interventions: PROCEDURE: subscapularis peel|PROCEDURE: osteotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Immune Response to an Unadjuvanted RSV Maternal Vaccine in Healthy Non-pregnant Females From 9 to 49 Years of Age
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: COMBINATION_PRODUCT: RSV MAT vaccine|COMBINATION_PRODUCT: dTpa vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: BYL719 Plus Letrozole or Exemestane for Patients With Hormone-Receptor Positive Locally-Advanced Unresectable or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic or Locally-advanced Unresectable Breast Cancer
Interventions: DRUG: BYL719|DRUG: Letrozole|DRUG: Exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 131I-IPA and Concurrent XRT in Recurrent GBM
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: RADIATION: 4-L-[131I]iodo-phenylalanine (131I-IPA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib, Lenalidomide and Dexamethasone Combination Therapy in Patients With Newly Diagnosed Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: Lenalidomide|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Inspiratory Muscle Training During Pulmonary Rehabilitation on Balance in COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Pulmonary rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Vudalimab or Pembrolizumab in Combination With Chemotherapy as First-line Treatment in Patients With Advanced NSCLC
Status: RECRUITING
Conditions: Nonsquamous Non-small Cell Lung Cancer
Interventions: COMBINATION_PRODUCT: Vudalimab + Carboplatin + Pemetrexed|COMBINATION_PRODUCT: Pembrolizumab + Carboplatin + Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conventional SILS vs Harmonic Scalpel SILS
Status: UNKNOWN
Conditions: Gallbladde Stones
Interventions: PROCEDURE: converntional SILC|PROCEDURE: Harmonic scalpel Single incision laparoscopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Action-Based Cognitive Remediation in Patients With Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder|Cognitive Impairment
Interventions: BEHAVIORAL: Action-Based Cognitive Remediation|BEHAVIORAL: Unstructured support group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 68Ga-DOTA-TATE PET/CT Imaging in NETs
Status: RECRUITING
Conditions: Neuroendocrine Tumors
Interventions: DIAGNOSTIC_TEST: 68Ga-DOTA-TATE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Improving Blood Lipid Management in Symptomatic Intracranial Atherosclerotic Stenosis on Clinical Outcome
Status: RECRUITING
Conditions: Intracranial Artery Stenosis
Interventions: DRUG: PCSK9 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Child Health Initiative for Lifelong Eating and Exercise (CHILE)
Status: TERMINATED
Conditions: Obesity
Interventions: BEHAVIORAL: classroom curriculum|BEHAVIORAL: In-service training for Head Start teachers/aides|BEHAVIORAL: Training for Head Start food service|BEHAVIORAL: Family intervention component|BEHAVIORAL: Food source|BEHAVIORAL: Health care providers|BEHAVIORAL: CHILE Head Start Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ENACT: A Study of ENX-101 as Adjunctive Treatment in Patients With Focal Seizures
Status: WITHDRAWN
Conditions: Focal Epilepsy
Interventions: DRUG: ENX-101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Nasoseptal Flap Harvest Technique on Olfaction Following Endoscopic Transsphenoidal Pituitary Surgery
Status: UNKNOWN
Conditions: Pituitary Tumor|Surgery|Olfactory Nerve Injuries
Interventions: PROCEDURE: Electrocautery versus scalpel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Randomized Study of Gemcitabine and Nab-paclitaxel in Combination With S- 1/LV (GASL) or Oxaliplatin (GAP) as First-line Treatment for Metastatic Pancreatic Cancer
Status: RECRUITING
Conditions: Phase II, Open-label, Parallel 2-arm, Multi-center
Interventions: DRUG: Gemcitabine 1000 mg|DRUG: Nab paclitaxel|DRUG: S1|DRUG: leucovorin|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Loncastuximab Tesirine in WM
Status: RECRUITING
Conditions: Waldenstrom Macroglobulinemia
Interventions: DRUG: Loncastuximab Tesirine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Topical Oxygen Therapy (Natrox™) Improve Wound Healing in Diabetic Foot Ulcers?
Status: UNKNOWN
Conditions: Diabetic Foot
Interventions: DEVICE: Natrox™ Oxygen Delivery System (ODS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Steady-State Comparative Bioavailability Study in Prophylaxis Patients of Lozanoc® 50 mg With Sporanox® 100 mg
Status: COMPLETED
Conditions: Neutropenia
Interventions: DRUG: Sporanox|DRUG: Lozanoc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: KHK2455 (IDO Inhibitor) Plus Avelumab in Adult Subjects With Advanced Bladder Cancer
Status: TERMINATED
Conditions: Urothelial Carcinoma
Interventions: DRUG: KHK2455|DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HylaCare in the Treatment of Acute Skin Changes in Patients Undergoing Radiotherapy for Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: HylaCare|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Interaction of Herbs and Statins
Status: COMPLETED
Conditions: Drug Interaction
Interventions: DRUG: Simvastatin 20 mg (Zocor®, MSD)|DRUG: rosuvastatin 10 mg (Crestor®, Astra Zeneca)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Endothelial Function, Inflammatory Disease Activity, and Bone and Cartilage Markers in Rheumatic Patients: The Influence of Antirheumatic Treatment
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Psoriatic Arthritis|Ankylosing Spondylitis|Endothelial Dysfunction|Inflammatory Disease Activity
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess the Efficacy and Safety of Ublituximab and Umbralisib in Participants With Chronic Lymphocytic Leukemia (CLL) Currently Treated With Ibrutinib, Acalabrutinib or Venetoclax
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Ublituximab|DRUG: Umbralisib|DRUG: Ibrutinib|DRUG: Venetoclax|DRUG: Acalabrutinib Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel, Oxaliplatin and S-1 (DOS) for Advanced Gastric Cancer
Status: COMPLETED
Conditions: Stomach Neoplasms
Interventions: DRUG: DOS (Docetaxel, Oxaliplatin and S-1)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venopuncture in Pediatric Emergency Department Using Koala's Distraction Method
Status: COMPLETED
Conditions: Nursing Caries|Emergencies|Venous Puncture
Interventions: PROCEDURE: Control group: Traditional venipuncture, on the stretcher.|PROCEDURE: Intervention group: DAK method venipuncture, simulating a hug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of TY-1091 in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: RET-altered Non Small Cell Lung Cancer|Medullary Thyroid Cancer|RET-altered Papillary Thyroid Cancer|Neoplasms
Interventions: DRUG: TY-1091
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxytocin and Emotion Recognition
Status: COMPLETED
Conditions: Health
Interventions: DRUG: Syntocinon 24 IU|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Room Air Levels of Harmful and Potentially Harmful Constituents After Heated Tobacco Product Use and Cigarettes
Status: RECRUITING
Conditions: Tobacco Smoking|Tobacco Use
Interventions: OTHER: Study Product A: Ploom® Non-Menthol Flavor|OTHER: Study Product B: Usual Brand Combustible Cigarette (UBCC) Non-Menthol Flavor|OTHER: Study Product C: Ploom® Menthol Heated Tobacco Product (HTP)|OTHER: Study Product D: Usual Brand Combustible Cigarette (UBCC) Menthol Flavor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impact of Sex in the Effect of Dietary Capsaicin on Cardiovascular Health
Status: RECRUITING
Conditions: Pre Hypertension|Hypertension
Interventions: DIETARY_SUPPLEMENT: Dietary capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Duloxetine in Major Depressive Disorder (MDD) and Associated Painful Symptoms
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Duloxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BMT-06: Study of Intensity Modulated Total Marrow Irradiation (IM-TMI)
Status: RECRUITING
Conditions: Acute Leukemia|MDS
Interventions: DEVICE: Arm1|DRUG: Arm1|DRUG: Arm1|DEVICE: Arm 1|OTHER: Arm1|DRUG: Arm1|DRUG: Arm1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest of Mycophenolate for CIDP Weaning
Status: COMPLETED
Conditions: Chronic Inflammatory Demyelinating Polyradiculopathy
Interventions: DRUG: Mycophenolate Mofetil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Awareness Levels of Caregivers of Disabled Children
Status: COMPLETED
Conditions: Cerebral Palsy|Caregiver Burden|Disabilities Multiple|Muscular Dystrophy|Down Syndrome|Spina Bifida
Interventions: OTHER: All of the disabled children's caregivers will answer the Questionnaire of Disease, Physiotherapy and Sports Awareness
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adjunctive Ivermectin Mass Drug Administration for Malaria Control
Status: UNKNOWN
Conditions: Malaria,Falciparum|Neglected Tropical Diseases|Strongyloidiasis|Lymphatic Filariasis|Scabies|Hook Worm|Soil Transmitted Helminths
Interventions: DRUG: Ivermectin|DRUG: Placebo|DRUG: Dihydroartemisinin-piperaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Banded Sleeve Gastrectomy Versus Banded Ring Gastric Bypass in Morbidly Obese Patients
Status: UNKNOWN
Conditions: Obesity
Interventions: PROCEDURE: Silastic® ring sleeve gastrectomy|PROCEDURE: Silastic® ring gastric bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot to Examine Risk and Feasibility of Remote Management of BP From CKD Through ESRD
Status: SUSPENDED
Conditions: Chronic Kidney Disease|Bloodpressure|Hypertension
Interventions: OTHER: Strict blood pressure control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT