pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Performances Evaluation of New FibroScan Probes Dedicated to Morbidly Obese Patients
Status: COMPLETED
Conditions: Obesity, Morbid|Liver Fibrosis
Interventions: DEVICE: For the first 60 patients: 3 XXL probe prototypes of the FibroScan 630 Research Model|DEVICE: From patient 61 to patient 120: 1 XXL probe prototype of the FibroScan 630 Research Model
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Probiotics or Berberine in Hepatic Steatosis Markers, Cardiometabolic and Microbiotic Profile in NAFL.
Status: UNKNOWN
Conditions: Non Alcoholic Fatty Liver|Obesity
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Berberine|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Probiotc and Berberine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Delirium in Elderly Patients With Trauma of the Hip
Status: TERMINATED
Conditions: Hip Fractures|Anesthesia
Interventions: DRUG: Bupivacaine|DRUG: Acetaminophen|DRUG: Diclofenac|DRUG: Ibuprofen|DRUG: Naproxen|DRUG: Dipyrone|DRUG: Fentanyl|DRUG: Morphine|DRUG: Levobupivacaine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: RCT,Double Blind, Placebo to Evaluate the Effect of Zinc and Ascorbic Acid Supplementation in COVID-19 Positive Hospitalized Patients in BSMMU
Status: UNKNOWN
Conditions: Covid19
Interventions: DIETARY_SUPPLEMENT: zinc gluconate and ascorbic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diet and Body Composition
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: Weight-loss diet strategy (+) exercise (PA)|OTHER: weight loss (-) exercise (PA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single-dose Study to Describe the Pharmacodynamics (PD) and Safety of Sarilumab (REGN88/SAR153191) and Tocilizumab in Adults With Rheumatoid Arthritis (RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Sarilumab|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Depth of Anesthesia on Implicit Memory
Status: COMPLETED
Conditions: Anesthesia, General|Memory
Interventions: COMBINATION_PRODUCT: BIS 40|COMBINATION_PRODUCT: BIS 60
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Classification of Adenocarcinoma of the Esophagogastric Junction
Status: UNKNOWN
Conditions: Oesophagus Cancer|Barrett Esophagus|Siewert Type I Adenocarcinoma of Esophagogastric Junction|Siewert Type II Adenocarcinoma of Esophagogastric Junction|Siewert Type III Adenocarcinoma of Esophagogastric Junction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Use of an Acellular Dermal Matrix in a Two-Staged Breast Reconstruction
Status: TERMINATED
Conditions: Mastectomy|Postoperative Pain|Complications
Interventions: PROCEDURE: Dermamatrix to cover lateral aspect of tissue expander|PROCEDURE: Serratus anterior to cover lateral aspect of tissue expander
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Application of an Incisional Wound Vac to Prevent Wound Complications in Obese Spine Surgery Patients
Status: UNKNOWN
Conditions: Spine Surgery|Wounds Vac
Interventions: DEVICE: Wound Vac|OTHER: Standard Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Impact of the Administration of Single Dose of Ivermectin in the Early Phase of COVID-19
Status: UNKNOWN
Conditions: To Assess the Reduction in the Viral Load of SARS-CoV-2 in Patients Receiving Ivermectin Compared to Those Receiving Standard Care
Interventions: DRUG: Ivermectin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With AIDS-Related Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: Bleomycin Sulfate|BIOLOGICAL: Filgrastim|DRUG: Cisplatin|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Doxorubicin Hydrochloride (DOX)|DRUG: Etoposide|DRUG: Fluorouracil|DRUG: Ifosfamide|DRUG: Leucovorin calcium|DRUG: Methotrexate|DRUG: Methylprednisolone|DRUG: Pentamidine|DRUG: Prednisone|DRUG: Trimethoprim-Sulfamethoxazole|DRUG: Vincristine Sulfate|DRUG: Zidovudine (AZT)|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Safety and Efficacy of Treosulfan Based Conditioning Prior to Allogeneic Haematopoietic Stem Cell Transplantation (HSCT)
Status: UNKNOWN
Conditions: Leukemia|Chronic Myeloid Leukemia|Myelodysplastic Syndrome|Diffuse Large Cell Lymphoma|Hodgkin Lymphoma|Chronic Lymphocytic Leukemia|Multiple Myeloma
Interventions: DRUG: Treosulfan IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Regorafenib in Refractory Advanced Gastro-Oesophageal Cancer
Status: UNKNOWN
Conditions: Gastro-Oesophageal Cancer
Interventions: DRUG: Regorafenib|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-eluting PTA Balloon Dilatation Catheter in the Treatment of Peripheral Artery Stenosis or Occlusion
Status: COMPLETED
Conditions: Peripheral Arterial Disease|Iliac Artery Stenosis|Femoral Artery Stenosis|Popliteal Artery Stenosis|Iliac Artery Occlusion|Femoral Artery Occlusion|Popliteal Artery Occlusion
Interventions: DEVICE: ZENFlow™ Drug-eluting PTA Balloon Dilatation Catheter|DEVICE: Peripheral Balloon Dilatation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Aflibercept and Standard Chemotherapy (R-CHOP) in First Line of Non Hodgkin B-cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Steroids Injection Versus PRP for Shoulder Pain Relief
Status: COMPLETED
Conditions: Shoulder Pain
Interventions: COMBINATION_PRODUCT: Platelet rich plasma|COMBINATION_PRODUCT: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing Lantus Algorithms to Achieve Normal Blood Glucose Targets in Subjects With Uncontrolled Blood Sugar With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atezolizumab and Bevacizumab With Photon Radiotherapy for Unresectable Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab|RADIATION: Photon radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Bariatric Surgery on Adipocyte Metabolism
Status: ACTIVE_NOT_RECRUITING
Conditions: Metabolic Syndrome|Obesity
Interventions: BEHAVIORAL: Circadian Clock Alignment|BEHAVIORAL: Circadian Clock Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: WayToServe Español: Online Responsible Beverage Service Training for Spanish-Speaking Servers
Status: COMPLETED
Conditions: Alcoholic Intoxication
Interventions: BEHAVIORAL: Implementation of WayToServe Español|BEHAVIORAL: Usual and Customary RBS Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Zirconia Implant Supported PEKK Crowns Versus Lithium Disilicate Crowns on Esthetics
Status: UNKNOWN
Conditions: Tooth Loss
Interventions: OTHER: poly ether ketone ketone|OTHER: lithium disilicate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Almonertinib With Chemotherapy in mEGFR NSCLC
Status: UNKNOWN
Conditions: Non-Small Cell Lung Cancer Metastatic
Interventions: DRUG: Almonertinib Pemetrexed/Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Dexmedetomidine During Non-Invasive Positive Pressure Ventilation
Status: COMPLETED
Conditions: Acute Respiratory Failure
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ANRS HC20 Effectiveness of an Optimized Anti HCV PegIFN-alpha2a + Ribavirin on Sustained Virological Response in Patients With HCV Genotype 1 and 4 Non Responders and Co-infected With HIV
Status: COMPLETED
Conditions: Hepatitis
Interventions: DRUG: Peg-interféron alpha 2a + ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study With Trabectedin Versus Adriamycin Plus Dacarbazine, in Patients With Advanced Solitary Fibrous Tumor
Status: ACTIVE_NOT_RECRUITING
Conditions: Solitary Fibrous Tumors
Interventions: DRUG: Trabectedin|DRUG: Adriamycin|DRUG: Dacarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgery With Botulinum Toxin A for Incisional Hernia
Status: NOT_YET_RECRUITING
Conditions: Incisional Hernia
Interventions: DRUG: BTA group|DRUG: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Parent and Family Oriented Support Interventions for the Facilitation of Weight Loss in African American Families
Status: RECRUITING
Conditions: Obesity-Related Malignant Neoplasm
Interventions: OTHER: Educational Activity|OTHER: Educational Intervention|OTHER: Informational Intervention|OTHER: Questionnaire Administration|PROCEDURE: Support Group Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of BDTX-4933 in Patients With KRAS, BRAF and Select RAS/MAPK Mutation-Positive Cancers
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer|Histiocytic Neoplasm|Histiocytosis|Melanoma|Melanoma (Skin)|BRAF Gene Mutation|BRAF V600E|BRAF V600 Mutation|BRAF Mutation-Related Tumors|BRAF|Metastatic Lung Non-Small Cell Carcinoma|Metastatic Melanoma|Metastatic Lung Cancer|Recurrent Melanoma|Recurrent Lung Cancer|Recurrent Lung Non-Small Cell Carcinoma|NSCLC|Solid Tumor|Solid Carcinoma|KRAS G12D|KRAS G12V|KRAS Mutation-Related Tumors|NRAS Gene Mutation|Thyroid Cancer|Thyroid Carcinoma|Colorectal Cancer|Colorectal Carcinoma|Recurrent Histiocytic and Dendritic Cell Neoplasm|Brain Metastases|Recurrent NSCLC|KRAS G13C|Acquired Resistance to KRAS G12C Inhibitor|KRAS G12A|KRAS G12F|KRAS G12R|KRAS G13D
Interventions: DRUG: BDTX-4933
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Active Surveillance, Post-Authorization Study to Characterize the Safety of Tofacitinib in Patients With Moderately to Severely Active Ulcerative Colitis in the Real-World Setting Using Data From the United Registries for Clinical Assessment and Research (UR-CARE) in the European Union (EU)
Status: RECRUITING
Conditions: Ulcerative Colitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Two Anti-HIV Regimens That Include One of Two Forms of Didanosine (ddI)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Nelfinavir mesylate|DRUG: Stavudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Ascending Doses of Inhaled AZD7594
Status: COMPLETED
Conditions: Safety|Pharmacokinetics|Pharmacodynamics of AZD7594
Interventions: DRUG: AZD7594|DRUG: Placebo to match
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: How Dose Coenzyme Q10 Supplementation During Infertility Treatment Effects Pregnancy Outcome
Status: TERMINATED
Conditions: Poor Ovarian Response
Interventions: DIETARY_SUPPLEMENT: Coenzyme Q10 co treatment|OTHER: Placebo Caps
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Convalescent Plasma Therapy on Critically-ill Novel Coronavirus (COVID-19) Patients
Status: COMPLETED
Conditions: IMMUNOTHERAPY
Interventions: BIOLOGICAL: Convalescent plasma|DRUG: Hydroxychloroquin with Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lack of Decision-making in Patients With Alzheimer's Disease : Functions Involved and the Daily Consequences
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DIAGNOSTIC_TEST: cognitive assessment|OTHER: Inhibition evaluation|OTHER: Assessment of mental flexibility|OTHER: Evaluation of the update|OTHER: working memory|OTHER: episodic memory
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Safety, Immunogenicity, and Efficacy of UB-612 COVID-19 Vaccine
Status: WITHDRAWN
Conditions: Covid-19|SARS-CoV-2|Coronavirus
Interventions: BIOLOGICAL: UB-612|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Iron and Chronic Obstructive Pulmonary Disease (COPD) Exercise Trial
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Ferric Carboxymaltose|DRUG: Sodium Chloride 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects-3
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DRUG: Atorvastatin|DRUG: Placebo to Atorvastatin|OTHER: Placebo to Ezetimibe|DRUG: Ezetimibe|OTHER: Placebo to Evolocumab|DRUG: Evolocumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Visual Telerehabilitation in AMD Patients
Status: TERMINATED
Conditions: Macular Degeneration
Interventions: DEVICE: Biofeedback Training|DEVICE: Immersive Virtual-Reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cell Savers and Blood Quality
Status: TERMINATED
Conditions: Coronary Artery Bypass, Off-Pump
Interventions: DEVICE: Xtra®, Sorin cellsaver|DEVICE: C.A.T.S.®, Fresenius cellsaver|DEVICE: CardioPAT®, Haemonetics, cellsaver|OTHER: no use of cell saver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Pharmacokinetic Study of CVM-1118 Extended-Release in Advanced Cancer Patients
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DRUG: CVM-1118 Extended-Release (ER) Capsules (200 mg/capsule)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Of Zoloft ODT To Jzoloft In Healthy Japanese Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JZoloft|DRUG: sertraline ODT|DRUG: sertraline ODT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Bipolar Disorder
Status: UNKNOWN
Conditions: Bipolar Depression
Interventions: BIOLOGICAL: Allogenic FMT|BIOLOGICAL: Autologous FMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Amplitude-Modulated Radiofrequency Electromagnetic Fields in Metastatic Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer|Metastatic Adenocarcinoma
Interventions: DRUG: Nab paclitaxel|DRUG: Gemcitabine|DEVICE: TheraBionic
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Additional Benefit of Cilostazol to Dual Antiplatelet Therapy After Biolimus-eluting Stent Implantation
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Cilostazol|DRUG: Aspirin|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy as an Adjuvant Therapy After Radiofrequency Ablation for Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma|Liver Cancer
Interventions: PROCEDURE: RFA|PROCEDURE: radiotherapy after RFA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Liposom With Citalopram in Elderly Patients With Major Depressive Disorder
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DRUG: Liposom Forte|DRUG: Citalopram|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TechStep: Technology-based Stepped Care to Stem Transgender Adolescent Risk Transmission
Status: COMPLETED
Conditions: HIV
Interventions: BEHAVIORAL: Text Messaging (Text+Step)|BEHAVIORAL: WebApp (App+Step)|BEHAVIORAL: Information/No Step
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05690 (Care Program) (P05710)
Status: COMPLETED
Conditions: Pregnancy|Neonates
Interventions: DRUG: Corifollitropin alfa|BIOLOGICAL: recFSH (follitropin beta)|DRUG: gonadatropin releasing hormone (GnRH) antagonist ganirelix|BIOLOGICAL: human chorion gonadotropin (hCG)|BIOLOGICAL: progesterone|DRUG: placebo-recFSH (follitropin beta)|DRUG: placebo-corifollitropin alfa|BIOLOGICAL: open-label recFSH (follitropin beta)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Antibody Responses to Pneumococcal Vaccines Among HIV-Infected Adults.
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: 7-valent pneumococcal conjugate vaccine (vaccine)|BIOLOGICAL: 23-valent pneumococcal conjugate vaccine (vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pomalidomide/Cyclophosphamide/Dexamethasone in Relapse Refractory Myeloma: Safety Profile in Mexicans
Status: UNKNOWN
Conditions: Multiple Myeloma in Relapse|Multiple Myeloma Progression|Refractory Multiple Myeloma
Interventions: DRUG: Pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TRIAD - Treatment of Insomnia and Depression
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders|Depression
Interventions: DRUG: Antidepressant|BEHAVIORAL: Desensitization Therapy for Insomnia|BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Home Blood Pressure-guided Antihypertensive Intervention for Elderly (HBP-GUIDE) Study
Status: WITHDRAWN
Conditions: Cardiovascular Disease|Vascular Disease|Hypertension
Interventions: PROCEDURE: Home blood pressure measurement|PROCEDURE: Office blood pressure measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The PK/PD Study of Single Dose of SHR3824 in Healthy Volunteers
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: SHR3824|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telehealth Delivered Home-based Walking for Vets With Peripheral Artery Disease
Status: NOT_YET_RECRUITING
Conditions: Peripheral Artery Disease
Interventions: BEHAVIORAL: Walking Program: Internet-based|BEHAVIORAL: Walking Program: Telehealth-based
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cardiovascular Outcomes and HbA1c Among Patients With Type 2 Diabetes Newly Initiating GLP1RAs vs Basal Insulin
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: GLP-1 receptor agonist|DRUG: Insulin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Insulin Glargine and NPH Human Insulin in Progression of Diabetic Retinopathy in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of High-intensity Aerobic Training on Balance, Walking Capacity, and Quality of Life in Patients With Sub-acute Stroke.
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Exercise Therapy|OTHER: conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study of a Fixed Dose Combination (FDC) Tablets of GSK587323
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: GSK587323|DRUG: FDC of candesartan cilexetil 16 mg and HCTZ 12.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nasal Outcomes Using Saline Irrigations After Endonasal Pituitary Surgery
Status: RECRUITING
Conditions: Pituitary Tumor
Interventions: OTHER: Nasal saline irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Acetazolamide on Right Heart Function During Exercise in Lowlanders Older Than 40 Years at Altitude
Status: ACTIVE_NOT_RECRUITING
Conditions: Altitude Hypoxia
Interventions: DRUG: ACETAZOLAMIDE oral capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 1/2a Study of the 2S,4R Enantiomer of Ketoconazole in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: 2S, 4R Ketoconazole (DIO-902)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Animal-Assisted Intervention
Status: NOT_YET_RECRUITING
Conditions: Animal Model|Pediatric|Emergencies|Fear|Nursing Caries
Interventions: OTHER: ANIMAL-ASSISTED INTERVENTION|OTHER: Routine Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Factors in Learning And Plasticity: Macular Degeneration
Status: RECRUITING
Conditions: Central Visual Impairment|Macular Degeneration
Interventions: BEHAVIORAL: Training visual sensitivity|BEHAVIORAL: Combination training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Nicardipine and Esmolol Applied for Controlled Hypotension
Status: COMPLETED
Conditions: Hypotension|Surgery-Complications|Oxygen Deficiency
Interventions: PROCEDURE: Controlled hypotention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Follow-Up in Women With Early Breast Cancer Three Years of More Post Primary Treatment
Status: RECRUITING
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Exercise Recall Patient Reported Outcomes|BEHAVIORAL: Health Behavior Questionnaire (HBQ)30 Patient Reported Outcomes|BEHAVIORAL: Functional Assessment of Cancer Therapy-General (FACT-G) Patient Reported Outcomes|BEHAVIORAL: Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) Patient Reported Outcomes|BEHAVIORAL: Patient Reported Outcomes PROMIS Cognitive Function (Short Form 8a)|BEHAVIORAL: Patient Reported Outcomes Functional Assessment of Cancer-Gynecology Oncology Group-Neurotoxicity (FACT/GOG-NTX-12)|BEHAVIORAL: Patient Reported Outcomes PROMIS|BEHAVIORAL: Patient Reported Outcomes FACT-Endocrine Symptoms|BEHAVIORAL: Patient Reported Outcomes Penn Arthralgia Aging Survey|BEHAVIORAL: Patient Reported Outcomes PRO-CTCAE (patient-reported CTCAE)|DIAGNOSTIC_TEST: p16 tumor suppressor gene
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tranexamic Acid in Chronic Subdural Hematomas
Status: RECRUITING
Conditions: Chronic Subdural Hematoma
Interventions: DRUG: Tranexamic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity, Safety and Tolerability of Two Doses of a Pre-pandemic Influenza Vaccine in Participants Aged 6 Months to 17 Years
Status: COMPLETED
Conditions: Prophylaxis of Avian Influenza
Interventions: BIOLOGICAL: H5N1 Influenza Vaccine|BIOLOGICAL: H5N1 Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Test Long-term Treatment With Spesolimab in People With Palmoplantar Pustulosis (PPP) Who Took Part in Previous Studies With Spesolimab
Status: TERMINATED
Conditions: Palmoplantar Pustulosis
Interventions: DRUG: Spesolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Efficacy Study of the New Medication ASK8007 to Treat Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: ASK8007|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Dendritic Cell Vaccine in Kidney Cancer
Status: RECRUITING
Conditions: Carcinoma, Renal Cell
Interventions: BIOLOGICAL: Autologous alpha-DC1/TBVA vaccine|DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment Of Vitamin D Role In The Pathogenesis Of Asthma In Vitamin D Resistent Patients
Status: COMPLETED
Conditions: Asthma|Vitamin D Resistant Rickets
Interventions: OTHER: Methacholine Challenge Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Pelvic Floor Muscle Training to Treat Urinary Incontinence After Radical Prostatectomy
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: BEHAVIORAL: Strength training of the pelvic floor muscles|BEHAVIORAL: strength training of the pelvic floor muscles with or without follow up instructions by a physiotherapist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of Postoperative Adjuvant Therapy for Cervical Cancer Based on MRD(Minimal Residual Disease)
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: Chemoradiotherapy + Adjuvant chemotherapy and Zimberelimab|DRUG: Chemoradiotherapy (small pelvic) + Zimberelimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Choice in Primary Dysmenorrhea
Status: COMPLETED
Conditions: Primary Dysmenorrhea
Interventions: DRUG: estradiol valerate/dienogest|DRUG: ethinylestradiol and drospirenone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Vorinostat Plus Melphalan and Prednisone (Zmp) in Advanced, Refractory Multiple Myeloma Patients
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Ranging Study to Evaluate the Glycemic Effects, Safety, and Tolerability of Metformin Delayed Release in Subjects With T2DM
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Met DR|DRUG: Met IR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prostate Localization During Radiotherapy Using a Ni-Ti Stent and Electronic Portal Imaging - Protocol II
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DEVICE: Radiotherapy stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Subgingivally Delivered Doxycycline Plus Ketoprofen Gel as an Adjunct to Non-surgical Periodontal Treatment
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: DRUG: 2.5%ketoprofen gel + 3 % doxycycline|DRUG: :2.5%ketoprofen gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of BRG01 in Subjects With Relapsed/Metastatic Epstein-Barr Virus (EBV)-Positive Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: EBV-positive Nasopharyngeal Carcinoma
Interventions: BIOLOGICAL: Cohort A: 3.0x10^6 CAR-T cells/kg|BIOLOGICAL: Cohort B: 9.0x10^6CAR-T cells/kg|BIOLOGICAL: Cohort C:1.5x10^7 CAR-T cells /kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liver Embolization Approaches for Tumor Management
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Cholangiocarcinoma|Metastatic Colon Cancer|Metastatic Cancer|Metastatic Gastric Cancer|Primary Liver Cancer|Metastatic Pancreatic Cancer
Interventions: PROCEDURE: Embolization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Identification of Novel Biomarkers of Cervicovaginal Mucosal Inflammation
Status: COMPLETED
Conditions: Vaginal Inflammation|Vaginal Infections
Interventions: DRUG: Imiquimod|OTHER: Placebo|DRUG: Nonoxynol-9
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Subjective Observational Study of Patients Using Medicated Footbath/Footwash Treatment in Podiatry Care
Status: UNKNOWN
Conditions: Toenail Fungal Infection|Cellulitis|Pitted Keratolysis|Diabetic Foot Ulcer|Abscess
Interventions: COMBINATION_PRODUCT: Footwash
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Open-label, Phase 2 Study of ACP-196 in Subjects With Waldenström Macroglobulinemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Waldenström Macroglobulinemia (WM)
Interventions: DRUG: Acalabrutinib (ACP-196)|DRUG: Acalabrutinib (ACP-196)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Ibrutinib Combination Therapy in Patients With Selected Gastrointestinal and Genitourinary Tumors
Status: COMPLETED
Conditions: Metastatic Renal Cell Carcinoma|Advanced Urothelial Carcinoma|Advanced Gastric Adenocarcinoma|Metastatic Colorectal Adenocarcinoma
Interventions: DRUG: ibrutinib|DRUG: everolimus|DRUG: paclitaxel|DRUG: docetaxel|DRUG: cetuximab|DRUG: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Routine Prescription Feedback and Peer Comparison to Lower Antibiotic Prescriptions in Primary Care
Status: COMPLETED
Conditions: Upper Respiratory Tract Infections|Urinary Tract Infections
Interventions: BEHAVIORAL: Antibiotic prescription feedback|BEHAVIORAL: No Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Carbon Ion Radiotherapy for the Treatment of Chinese Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: RADIATION: carbon-ion radiotherapy for tumor away from GI|RADIATION: carbon-ion radiotherapy for tumor adjacent to GI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-response Effect of Whey Protein Consumed as Pre-meal on Postprandial Lipaemia in Subjects With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: OTHER: Whey protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dissection of the Gastrointestinal-mediated Glucose Disposal and Incretin Defect in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: LY2409021|DRUG: LY2409021 placebo|PROCEDURE: OGTT|PROCEDURE: IIGI|PROCEDURE: Standardised liquid meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Tolerability of Sensoril® in Improving Immunity and Thereby Reducing Incidence of Upper Respiratory Tract Infections
Status: COMPLETED
Conditions: Immune Health
Interventions: OTHER: Aqueous extract of roots plus leaves of Withania somnifera 125 mg|OTHER: Aqueous extract of roots plus leaves of Withania somnifera 250 mg|OTHER: Microcrystalline Cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of PCSK-9 Inhibitor Treatment Prior to Undergoing Primary Percutaneous Coronary Intervention in Patients With ST-segment Elevation Myocardial Infarction
Status: RECRUITING
Conditions: STEMI
Interventions: DRUG: evolocumab|PROCEDURE: standard post-treatment for STEMI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Tirzepatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Actiponin on Antiobesity in Obese Korean Subjects.
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Actiponin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Mechanisms and Interventions to Address Cardiovascular Risk of Gender-affirming Hormone Therapy in Trans Men
Status: WITHDRAWN
Conditions: Hypertension|Hyperlipidemias
Interventions: DRUG: Atorvastatin|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: GIANT: General Practitioner Implementation in Asia of Normoglycaemic Targets
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Education of general practitioners on the IDF-WPR guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Trial to Evaluate Ultrasonic Surgical Device in Chronic Pressure Ulcer
Status: COMPLETED
Conditions: Pressure Ulcer|Wound|Necrosis
Interventions: DEVICE: ULSD-12D|DEVICE: SONOCA-180
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prescribing Opioid Pain Relievers in the Emergency Department: Understanding and Optimizing the Encounter
Status: COMPLETED
Conditions: Opioid Use, Unspecified
Interventions: BEHAVIORAL: Additional Opioid Information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: SENSE-VM: Safety and Effectiveness of a Novel Medical Device for Symptom Ease in Vestibular Migraines
Status: RECRUITING
Conditions: Vestibular Migraine|Migraine Associated Vertigo
Interventions: DEVICE: Otoband Experimental|DEVICE: Otoband Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy for Sentinel Lymph Node Policy in Intermediate-risk Endometrial Carcinomas
Status: WITHDRAWN
Conditions: Endometrial Endometrioid Adenocarcinoma
Interventions: PROCEDURE: SLN arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temozolomide Plus Lomustine Followed by Radiation Therapy in Treating Patients With High-Grade Malignant Glioma
Status: COMPLETED
Conditions: Brain Tumor|Central Nervous System Tumor
Interventions: DRUG: lomustine|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Novel Therapy for Breast Cancer Survivors With Genitourinary Syndrome of Menopause
Status: RECRUITING
Conditions: Breast Cancer|Genitourinary Syndrome of Menopause
Interventions: BIOLOGICAL: Platelet-rich plasma (PRP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acute Physiological Effects of Greek Traditional Dancing
Status: RECRUITING
Conditions: Menopause|Cardiovascular Health|Body Composition|Physical Performance|Muscle Damage
Interventions: OTHER: Slow tempo|OTHER: Moderate tempo|OTHER: Fast tempo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Conventional Free Gingival Grafts With Partially De-epithelized Free Gingival Grafts
Status: COMPLETED
Conditions: Gingival Recession
Interventions: PROCEDURE: Comparison of conventional free gingival graft versus partial free gingival graft|PROCEDURE: Comparison of conventional free gingival graft versus partial free gingival graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PrEP Affect Regulation Treatment Innovation
Status: RECRUITING
Conditions: Medication Adherence|HIV Prevention|Stimulant Use
Interventions: BEHAVIORAL: PARTI|BEHAVIORAL: Attention-Control|BEHAVIORAL: Contingency Management for PrEP Adherence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Alleviating the Metabolic Side Effects of Antipsychotic Medications
Status: WITHDRAWN
Conditions: Schizophrenia
Interventions: DRUG: Moxonidine|DRUG: Placebo|DRUG: Moxonidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Standardized Perioperative Management of Patients Operated With Acute Abdominal Surgery in a High-risk Emergency Setting
Status: ACTIVE_NOT_RECRUITING
Conditions: Laparotomy|Peritonitis|Ileus|Perforated Bowel|Acute Abdomen
Interventions: OTHER: Standardised protocol for the perioperative management in patients in need of an acute laparotomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intravitreal Ranibizumab Injection for Aggressive Versus Type 1 Prethreshold Retinopathy of Prematurity
Status: COMPLETED
Conditions: Retina Disease|Retinopathy of Prematurity|Ranibizumab
Interventions: DRUG: Ranibizumab (0.25 mg/0.025 mL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Monitoring luminAl Breast Cancer Through the Evaluation of Mutational and epiGeNEtic alteraTIons of Circulating ESR1 DNA
Status: RECRUITING
Conditions: Hormone Receptor Positive Breast Carcinoma|Breast Neoplasms|Neoplasms, Breast|Breast Diseases|Antineoplastic Agents|Aromatase Inhibitors|ESR1 Gene Mutation
Interventions: DIAGNOSTIC_TEST: Liquid biopsy and CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB133 (Dapirolizumab Pegol) in Healthy Japanese and Caucasian Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: BIIB133 (Dapirolizumab pegol)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Knee Stability Training for Knee Osteoarthritis (OA)
Status: COMPLETED
Conditions: Osteoarthritis|Joint Diseases
Interventions: OTHER: Traditional exercise therapy for knee osteoarthritis|OTHER: Knee stability training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Choline PET/CT vs. Dual Time Point FDG PET/CT in Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DEVICE: Choline PET/CT and Dual time point FDG PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Efficacy and Safety of Intracranial Stent (Tonbridge) in Endovascular Treatment of Intracranial Atherosclerotic Stenosis
Status: NOT_YET_RECRUITING
Conditions: Intracranial Atherosclerosis
Interventions: DEVICE: Intracranial Stent (Tonbridge)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peer-to-Peer Support Program in Improving Quality of Life Outcomes in Patients With Gynecologic Cancer and Their Caregivers
Status: TERMINATED
Conditions: Cervical Carcinoma|Ovarian Carcinoma|Uterine Corpus Cancer|Vaginal Carcinoma|Vulvar Carcinoma
Interventions: PROCEDURE: Supportive Care|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Performance Assessment of the SYMBOL Range of Medical Devices in Patients Underlying Total Hip Arthroplasty
Status: RECRUITING
Conditions: Degenerative Hip Joint Disease|Post-traumatic Osteoarthritis|Hip Arthritis|Femoral Neck Fractures|Avascular Necrosis of the Femoral Head|Failure of Prosthetic Joint Implant
Interventions: DEVICE: Total hip arthroplasty (primary or revision)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p