pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study Evaluating the Efficacy and Safety of HSK3486 for Sedation
Status: COMPLETED
Conditions: Sedation
Interventions: DRUG: HSK3486 0.1-0.2 /0.3 mg / kg group|DRUG: Propofol 0.5-1.0/1.5 mg/kg group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Evaluate the Safety and Efficacy of RM-131 in Patients With Parkinson's Disease & Chronic Constipation
Status: TERMINATED
Conditions: Parkinson's Disease
Interventions: DRUG: RM-131|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: coMparison Between invAsive and Non-invasive assessmenT on Blood Pressure and Cardiac Function in HealthY Participants
Status: UNKNOWN
Conditions: Healthy Volunteer
Interventions: DIAGNOSTIC_TEST: Invasive left ventricular diastolic function assessment|DIAGNOSTIC_TEST: Invasive aortic blood pressure measurement|DIAGNOSTIC_TEST: Non-Invasive left ventricular diastolic function assessment|DIAGNOSTIC_TEST: Non-Invasive aortic blood pressure measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Continuous Nerve Block Block vs Combination of Single Block Plus Intravenous Lidocaine for Postoperative Pain.
Status: TERMINATED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Continuous Erector Spinae Plane Nerve Block|PROCEDURE: Continuous Quadratus Lumborum Nerve Block|PROCEDURE: Single Erector Spinae Plane Nerve Block|PROCEDURE: Single Quadratus Lumborum Nerve Block|DRUG: Lidocaine IV|DRUG: Ropivacaine 0.5% Injectable Solution|DRUG: Dexamethasone|DRUG: Dexmedetomidine|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Castration Resistant Prostate Cancer Using Multi-Targeted Recombinant Ad5 PSA/MUC1/Brachyury Based Immunotherapy Vaccines
Status: COMPLETED
Conditions: Prostatic Neoplasms|Prostatic Cancer
Interventions: BIOLOGICAL: ETBX-071; adenoviral PSA vaccine|BIOLOGICAL: ETBX-061; adenoviral MUC1 vaccine|BIOLOGICAL: ETBX-051; adenoviral brachyury vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spectroscopy of Breast Tissue
Status: COMPLETED
Conditions: Breast Cancer
Interventions: GENETIC: fluorescence in situ hybridization|OTHER: immunohistochemistry staining method|OTHER: medical chart review|PROCEDURE: fluorescence spectroscopy|PROCEDURE: histopathologic examination|PROCEDURE: light-scattering spectroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PROPEL-2: Prophylactic Negative Pressure Wound Therapy in Laparotomy Wounds
Status: RECRUITING
Conditions: Wound Surgical|Wound Infection|Cosmesis
Interventions: DEVICE: Negative Pressure Wound Therapy|OTHER: Standard wound dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Three Experimental HIV Vaccines in Healthy Adults.
Status: UNKNOWN
Conditions: HIV-1-infection
Interventions: BIOLOGICAL: Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Indocyanine Green Fluorescence Uptake in Human Carotid Artery Plaque
Status: COMPLETED
Conditions: Atherosclerosis|Atherosclerotic Plaque|Carotid Stenosis
Interventions: DRUG: Indocyanine green
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Fatty Flap Taken From the Double Chin for Chin Enhancement: a New Surgical Technique
Status: COMPLETED
Conditions: Adiposity|Micrognathism
Interventions: PROCEDURE: chin enhancement with a fatty flap sculpted from the double chin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplementation of Phosphatidylserine (PS) and n-3 Long Chain Fatty Acids (EPA, DHA) in Children With ADHD
Status: COMPLETED
Conditions: Attention-Deficit/Hyperactivity Disorder
Interventions: DRUG: Phosphatidylserine-Omega3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Marine Oils and Arthritis
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DIETARY_SUPPLEMENT: Whale blubber oil|DIETARY_SUPPLEMENT: Cod liver oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Visceral Analgesic Effect of Erector Spinae Plane Block in Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Visceral Pain, Postoperative
Interventions: DRUG: Ultrasound guided Rectus sheath block|DRUG: Ultrasound erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety of RotigotiNe in Patients With Autosomal Dominant Polycystic Kidney Disease
Status: NOT_YET_RECRUITING
Conditions: Kidney Diseases
Interventions: DRUG: standard care + rotigotine at 4 mg/24h for 24 months.|DRUG: standard care for 24 months.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: General Versus Regional Anaesthesia in Peripheral Arterial Surgery: Incidence of Postoperative Pulmonary Complications.
Status: UNKNOWN
Conditions: Peripheral Vascular Diseases
Interventions: PROCEDURE: Regional anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Impact of Physical Reconditioning Associated With Specific Nutritional Supplementation in Obese Patients Suffering From Metabolic Syndrome
Status: COMPLETED
Conditions: Obesity|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: L-Leucine and L-arginine|OTHER: Physical Reconditioning by a trainer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Arginine on Microcirculation in Patients With Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: L-arginine|DIETARY_SUPPLEMENT: Placebo Lactose powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Newly Designed Fully Covered Metal Stent for the Benign Biliary Stricture
Status: COMPLETED
Conditions: Bile Duct Disease
Interventions: DEVICE: Bona stent® (Flared end FCSEMS)|DEVICE: Hanarostent® (Anchoring FCSEMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Mesenchymal Stem Cells For Moderate and Severe Bronchopulmonary Dysplasia
Status: UNKNOWN
Conditions: Bronchopulmonary Dysplasia
Interventions: DRUG: Transplantation of mesenchymal stem cell|DRUG: No Transplantation of Mesenchymal Stem Cell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Growth Hormone Treatment in Subjects With Metabolic Syndrome.
Status: WITHDRAWN
Conditions: Metabolic Syndrome
Interventions: DRUG: Norditropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Study of Cefazolin Versus Cefazolin Plus Azithromycin Prophylaxis in Post-Cesarean Endometritis
Status: WITHDRAWN
Conditions: Endometritis
Interventions: DRUG: Azithromycin|DRUG: Cefazolin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of Fosmetpantotenate (RE-024) in PKAN Participants
Status: TERMINATED
Conditions: Pantothenate Kinase-Associated Neurodegeneration
Interventions: DRUG: Fosmetpantotenate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Decision Tool to Select Women for Gynecologic Sparing Radical Cystectomy
Status: RECRUITING
Conditions: Urothelial Carcinoma Bladder
Interventions: PROCEDURE: Reproductive organ sparing radical cystectomy|PROCEDURE: Radical cystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Interleukin (IL)-17A Inhibition on Idiopathic Subglottic Stenosis
Status: NOT_YET_RECRUITING
Conditions: Idiopathic Subglottic Stenosis
Interventions: DRUG: Taltz
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Dichoptic Therapy to Treat Intermittent Exotropia
Status: RECRUITING
Conditions: Exotropia Intermittent
Interventions: DEVICE: Luminopia, a virtual reality headset|OTHER: Paper pre- survey|OTHER: Paper Survey
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effect of Colla Corii Asini on Improving Anemia and Hemoglobin Composition in Pregnant Women With Thalassemia
Status: UNKNOWN
Conditions: Thalassemia
Interventions: DRUG: Colla corii asini
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Perineural Dexamethasone on the Duration of Popliteal Nerve Block for Anesthesia After Ankle Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Nerve Block
Interventions: DRUG: Dexamethasone Sodium Phosphate|DRUG: Ropivacaine Hydrochloride Inj 2 mg/ml|DRUG: Sodium Chloride 9mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient-ventilator Asynchrony in Conventional Ventilation Modes During Short-term Mechanical Ventilation After Cardiac Surgery
Status: COMPLETED
Conditions: Thoracic Surgery
Interventions: DEVICE: VCV+PSV|DEVICE: PCV+PSV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of New Biomarkers on Maintenance of Sinus Rhythm After Cardioversion or Ablation of Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Ablation of atrial fibrillation|PROCEDURE: Cardioversion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of the Safety, Tolerability and Prelinminary Efficacy of BD111 in Herpes Simplex Virus Type I Stromal Keratitis
Status: RECRUITING
Conditions: Herpes Simplex Virus Type I Stromal Keratitis
Interventions: GENETIC: BD111 Injection (Investigative New Drug)|COMBINATION_PRODUCT: Triple-drugs therapy of HSV-1 stromal keratitis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Semaglutide Ingection in Subjects With Type 2 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: Semaglutide|DRUG: Semaglutide Pen Injector [Ozempic]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Formula PTX Renal Stent Clinical Study
Status: COMPLETED
Conditions: Renal Artery Stenosis
Interventions: DEVICE: Formula PTX Stent - Dose 1|DEVICE: Formula PTX Stent - Dose 2|DEVICE: Formula PTX Stent - Dose 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DIETARY_SUPPLEMENT: Lactobacillus rhamnosus GG|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: ET-01 in Subjects With Lateral Canthal Lines, LCL-210
Status: ACTIVE_NOT_RECRUITING
Conditions: Lateral Canthal Lines, LCL|Crow's Feet
Interventions: BIOLOGICAL: Vehicle|BIOLOGICAL: botulinum toxin, Type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sleep Respiratory Disorders in Patients With Moderate to Severe Persistent Rhinitis
Status: RECRUITING
Conditions: Rhinitis
Interventions: DEVICE: Measure of mandibular movement using a mid-sagittal magnetic sensor (Brizzy, Jawac©) Nomics, Liege, Belgium)|DEVICE: Gold standard: polysomnography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Euclid Phoenix Lens Design Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Myopia|Cornea
Interventions: DEVICE: Euclid orthokeratology MAX (current design)|DEVICE: Euclid orthokeratology MAX Phoenix (new design)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of CS-7017 in Combination With FOLFIRI in Subjects With Metastatic Colorectal Cancer Who Failed First-Line Therapy
Status: COMPLETED
Conditions: Colorectal Cancer|Neoplasms, Colorectal
Interventions: DRUG: CS7017|DRUG: irinotecan, leucovorin, and 5-fluorouracil (5-FU) (FOLFIRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study Between "DA-5209 Tab" and "Lixiana Tab"
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DA-5209 60mg Tab|DRUG: DA-5209 60mg Tab|DRUG: Lixiana 60mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Transpulmonary Pressure - Guided Mechanical Ventilation in Morbidly Obese ARDS Patients: a Feasibility Study.
Status: RECRUITING
Conditions: ARDS, Human|Obesity, Morbid
Interventions: OTHER: Esophageal pressure-guided strategy,
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pemetrexed in Patients With Chemosensitive and Chemoresistant Relapsed Small Cell Lung Cancer
Status: TERMINATED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Anatomically Aligned and Conventional Total Knee Arthroplasty in the Same Patients
Status: UNKNOWN
Conditions: Knee Osteoarthritis|Anatomically Aligned Total Knee Arthroplasty
Interventions: DEVICE: Anatomically aligned total knee arthroplasty implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clarithromycin 500 mg Extended Release Tablets Under Non-Fasting Conditions.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Clarithromycin ER 500 mg tablets|DRUG: BIAXIN® XL 500 mg tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Post-PACU Pain Management in Pediatric Surgery
Status: RECRUITING
Conditions: Pain
Interventions: OTHER: Additional face-to-face education|OTHER: Standard of care management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Renal Autologous Cell Therapy (REACT) in Subjects With Type 1 or 2 Diabetes and Chronic Kidney Disease (REGEN-007)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Kidney Diseases|Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus
Interventions: BIOLOGICAL: Renal Autologous Cell Therapy (REACT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of SGN-40 in Patients With Refractory or Recurrent Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: SGN-40 (anti-huCD40 mAb)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Warfarin Patient Self-management Implementation in the US Healthcare System
Status: RECRUITING
Conditions: Atrial Fibrillation|Venous Thromboembolism|Heart Valve Diseases
Interventions: OTHER: Patient self-management|OTHER: Usual care provided by anticoagulation providers
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Three-Dose Regimen of MRKAd5+6 Trigene (V526) in Healthy Adults (V526-001)(COMPLETED)
Status: COMPLETED
Conditions: HIV|HIV Infections
Interventions: BIOLOGICAL: V526|BIOLOGICAL: Comparator: Placebo to V526
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Anti-craving Efficacy of Right and Left Prefrontal High Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) in Alcohol Dependence
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DEVICE: Magstim Rapid® (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Value of Non-invasive Dual-Pet Information in Subtype of Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: PROCEDURE: biopsy or surgical pathology in metastases|DRUG: 68Ga-HER2 affibody,18F-FDG, 18F-FES
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phamacokinetics and Safety Profiles of DA-1229_01 5/1000mg in Healthy Subjects at Fed State
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DRUG: DA-1229_01 5/1000mg (Before)|DRUG: DA-1229_01 5/1000mg (After)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Energy Consumption and Cardiorespiratory Load During Robot-Assisted Gait Training in Non-Ambulatory Stroke Patients
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Regular therapy settings|DEVICE: 100% guidance force|DEVICE: 60% guidance force
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Milk as a Recovery Beverage After Exercise for Improving Metabolic Health
Status: COMPLETED
Conditions: Hyperlipemia, Carbohydrate Inducible
Interventions: BEHAVIORAL: Exercise|OTHER: Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Investigate the Potential Drug-Drug Interaction Between VH4524184 and Oral Contraceptive (Loestrin) in Healthy Adult Female Participants
Status: RECRUITING
Conditions: HIV Infections
Interventions: DRUG: VH4524184|DRUG: Loestrin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Treatment With Palbociclib and Exemestane Plus Trastuzumab and Pyrotinib in Estrogen Receptor (ER)-Positive, HER2-positive Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Neoadjuvant Treatment for HER2-positive, ER-positive Breast Cancer
Interventions: DRUG: palbociclib and exemestane plus trastuzumab and pyrotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate The Safety and Initial Efficacy of STSA-1002 Injection in Patients With Acute Respiratory Distress Syndrome
Status: RECRUITING
Conditions: Acute Respiratory Distress Syndrome
Interventions: DRUG: STSA-1002 Injection Placebo|DRUG: STSA-1002 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Safety & Efficacy Study Evaluating The Effect of A4250 in Children With PFIC
Status: ACTIVE_NOT_RECRUITING
Conditions: Progressive Familial Intrahepatic Cholestasis
Interventions: DRUG: A4250 (odevixibat)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3015014 in Otherwise Healthy Participants With High Low-density Lipoprotein (LDL) Cholesterol
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: LY3015014|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Endocrowns vs.Ceramic Onlays Used in Endodontically Treated Teeth- Randomized Clinical Study
Status: COMPLETED
Conditions: Ceramic Restorations in Endodontically Treated Teeth
Interventions: PROCEDURE: Endocrown|PROCEDURE: Onlay and fiber pin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glucagon-like Peptide 1 Agonist Exenatide for Improved Glucose Control and Cardiac Function in Patients With Aortocoronary Bypass
Status: COMPLETED
Conditions: Coronary Artery Disease|Decreased Left Ventricular Function
Interventions: DRUG: Exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: High-dose Vitamin D Supplement for the Prevention of Acute Asthma-like Symptoms in Preschool Children
Status: RECRUITING
Conditions: Asthma in Children
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol D3|OTHER: Oral placebo suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: "Unifuzol®" in Patients With Peripheral Arterial Disease
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DRUG: L-arginine 1.4% 500 ml|DRUG: L-arginine 1.4% 250 ml + placebo 250 ml|DRUG: Placebo solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALN-TTRSC04 in Healthy Subjects
Status: RECRUITING
Conditions: Transthyretin-Mediated Amyloidosis
Interventions: DRUG: ALN-TTRSC04|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: New Treatment for Donor Sites
Status: WITHDRAWN
Conditions: Burn
Interventions: DRUG: Application of donor site dressing [scarlet red, Microbial Nanocellulose (NC), or hyaluronan and thrombin (HT)]|PROCEDURE: Blood sample|PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety, Tolerability and Efficacy of Garetosmab Versus Placebo Administered Intravenously (IV) in Adult Participants With Fibrodysplasia Ossificans Progressiva (FOP)
Status: ACTIVE_NOT_RECRUITING
Conditions: Fibrodysplasia Ossificans Progressiva
Interventions: DRUG: Garetosmab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Diagnostic Tests in Patients With Suspected Invasive Candidiasis in Internal Medicine Wards and Who Are Currently Timely Treated With Micafungin
Status: TERMINATED
Conditions: Invasive Candidiasis
Interventions: DIAGNOSTIC_TEST: 1,3-β-D-glucan quantification|DRUG: Micafungin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immuno-Virological Efficacy of Combination With Trizivir +Tenofovir in Multiresistant HIV Patients
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: Trizivir (AZT+3HT+Abacavir) twice daily|DRUG: Viread (300 mg Tenofovir disoproxil fumarate) once daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 6-Week Study To Determine The Safety And Effect Of An Investigational Drug Given With Canagliflozin In Adults With Type 2 Diabetes Mellitus Taking Metformin
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: PF-05175157|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess the Efficacy & Safety of KHK4951 in Patients With Diabetic Macular Edema
Status: RECRUITING
Conditions: Diabetic Macular Edema (DME)
Interventions: DRUG: KHK4951|DRUG: Aflibercept Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Effectiveness of a Brief Intervention for Substances Consumption Linked to the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST): A Randomized Control Trial in Chilean Primary Care."
Status: COMPLETED
Conditions: Alcohol-Related Disorders|Substance-Related Disorders|Substance Abuse
Interventions: OTHER: ASSIST-linked brief intervention for hazardous and harmful substance use.|OTHER: Observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Periodic Limb Movements Among Dialysis and Non-dialysis Chronic Kidney Disease Patients
Status: COMPLETED
Conditions: The Aim of the Study Was to Screen Prevalence of Periodic Limb Movements Among Chronic Kidney Disease Patients
Interventions: DIAGNOSTIC_TEST: Polysomnography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Biomatrix Versus Gazelle in ST-Elevation Myocardial Infarction (STEMI)
Status: COMPLETED
Conditions: ST-elevation Myocardial Infarction
Interventions: DEVICE: Biolimus eluted from an erodable stent coating (Biomatrix)|DEVICE: bare-metal stent (Gazelle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Concentrated Pomegranate Juice Consumption on Lipid Profile and Inflammatory Factors in Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: OTHER: 50 gr concentrated pomegranate juice
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of Non-invasive Hemoglobin (SpHb) Measurement in Children
Status: COMPLETED
Conditions: Non-invasive Hb Measurement in Children
Interventions: DEVICE: non-invasive measurement of Hb|PROCEDURE: taking blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hospital- and Home-based Supervised Exercise Versus UNsupervised Walk Advice For Patients With InTermittent Claudication
Status: UNKNOWN
Conditions: Intermittent Claudication
Interventions: PROCEDURE: WA|PROCEDURE: SET|PROCEDURE: HET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multifocal Lens Design Evaluation
Status: COMPLETED
Conditions: Refractive Error|Presbyopia
Interventions: DEVICE: Delefilcon A multifocal contact lens|DEVICE: Lotrafilcon B multifocal contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Effect of Individualized Training Versus Non-individualized Training to Improve Quality of Life of Sedentary Employees
Status: TERMINATED
Conditions: Exercise|Healthy Volunteers|Health|Quality of Life
Interventions: OTHER: Performing following WHO (World Health Organization)|OTHER: Performing on their needs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Post-market Surveillance Study of the BD® WavelinQ™ EndoAVF System
Status: RECRUITING
Conditions: Kidney Disease, End-Stage|End-stage Renal Disease|Arteriovenous Fistula
Interventions: DEVICE: EndoAVF Creation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics/Pharmacodynamics (PK/PD) Characteristics of Tolvaptan Tablet in Korean Healthy Male
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tolvaptan 15mg or 30mg or 60mg or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Tofacitinib in Subjects With Active Ankylosing Spondylitis (AS)
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: DRUG: Tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pediatric Intubation by Nurses
Status: UNKNOWN
Conditions: Intubation|Cardiac Arrest
Interventions: DEVICE: AWS|DEVICE: Intubrite|DEVICE: AirTraq|DEVICE: MIL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Dysrhythmias on the Cardiac Intensive Care Unit - Does Maintenance of High-normal Serum Potassium Levels Matter
Status: COMPLETED
Conditions: Arrhythmias, Cardiac
Interventions: DRUG: Potassium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study of Bradanicline in Refractory Chronic Cough
Status: COMPLETED
Conditions: Chronic Cough
Interventions: DRUG: Bradanicline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Advanced Sperm Selection Techniques and Their Contribution to Blastocyst Euploidy Rates
Status: COMPLETED
Conditions: Sperm DNA Fragmentation|Infertility
Interventions: OTHER: PICSI|OTHER: MACS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: POL6326 (Balixafortide) Plus Nab-paclitaxel or Eribulin in Patients With HER2-negative Advanced Breast Cancer
Status: WITHDRAWN
Conditions: Advanced Breast Cancer
Interventions: DRUG: POL6326|DRUG: Eribulin|DRUG: Nab paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Urology San Antonio MRI/MicroUS Comparison
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: Micro-ultrasound targeted biopsy|DIAGNOSTIC_TEST: mpMRI targeted biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Bringing Relief to Adolescents Naturally Using Melatonin for Migraine
Status: COMPLETED
Conditions: Migraine in Adolescents
Interventions: DRUG: Melatonin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Vasovagal Syncope
Status: UNKNOWN
Conditions: Vasovagal Syncope|Postural Tachycardia Syndrome
Interventions: DRUG: Phenylephrine|DRUG: L-Ng-monomethyl Arginine (L-NMMA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nasal Muco-ciliary Clearance Study With and Without Salt Inhalation
Status: UNKNOWN
Conditions: Obstructive Airway Diseases
Interventions: DEVICE: Inhalation from a salt particle inhaler with or without content
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Optic Neuropathy in 10 Patients With Glioblastoma Receiving Bevacizumab
Status: WITHDRAWN
Conditions: Glioblastoma|Optic Neuropathy
Interventions: DRUG: Bevacizumab (Avastin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SLV308 for Treatment of Patients With Early Parkinson's Disease
Status: COMPLETED
Conditions: Early Stage Parkinson's Disease
Interventions: DRUG: pardoprunox|DRUG: Pardoprunox|DRUG: Pardoprunox|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RTA 408 Lotion in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: RTA 408 Lotion 0.5%, 1%, 3%|DRUG: Lotion vehicle/placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Risk Factors for the Occurrence and Severity of Exertional Heatstroke in the Military Environment
Status: RECRUITING
Conditions: Heat Stroke
Interventions: OTHER: Saliva collection|BEHAVIORAL: Questionnaires|OTHER: Ingestible core temperature capsule intake|OTHER: Physical exercise|OTHER: Heart rate monitoring|OTHER: Core temperature monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Vitamin D3 on Cardiovascular Risk Factors
Status: COMPLETED
Conditions: Hypertensive Disease|Deficiency of Vitamin D3
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound for Rectus Femoris Measurement
Status: WITHDRAWN
Conditions: Muscle Atrophy, Proximal|Muscle Atrophy|ACL Tear|Quadriceps Muscle Atrophy
Interventions: DEVICE: 892.1550 Ultrasonic pulsed doppler imaging system|DIAGNOSTIC_TEST: Thigh circumference measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Saline Irrigation at Different Temperatures on Pain, Edema, and Trismus After Impacted Third Molar Surgery
Status: COMPLETED
Conditions: Impacted Third Molar Tooth
Interventions: PROCEDURE: 4 °C colled saline irrigation|PROCEDURE: 10 °C cooled saline irrigation|PROCEDURE: Room temperature saline irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combining Varenicline and Guanfacine for Smoking Cessation
Status: RECRUITING
Conditions: Smoking Cessation
Interventions: DRUG: Varenicline|DRUG: Guanfacine ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Different Approaches for Delivery of IPT in Pregnancy in Burkina Faso
Status: COMPLETED
Conditions: Malaria Parasitaemia|Birth Weight|Anaemia
Interventions: OTHER: delivery approaches of malaria intermittent preventive treatment in pregnancy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability Study With Single Ascending Doses of ORM-12741
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ORM-12741
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Bioavailability of Three Hesperidin Extracts.
Status: COMPLETED
Conditions: Biological Availability
Interventions: DIETARY_SUPPLEMENT: Hesperidin Pharma|DIETARY_SUPPLEMENT: Hesperidin Pharma_M|DIETARY_SUPPLEMENT: Cardiose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Cognitive-Behavioral Conjoint Therapy (CBCT) Project
Status: COMPLETED
Conditions: Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: CBCT-Home Based (CBCT-HB)|BEHAVIORAL: CBCT-Office Based (CBCT-OB)|BEHAVIORAL: PTSD Family Education (PFE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy, Safety, and Tolerability of Oral NORA520 in Adults With Severe Postpartum Depression
Status: RECRUITING
Conditions: Depression, Postpartum|Postpartum Depression|Post-partum Depression|Postnatal Depression|Post-Natal Depression
Interventions: DRUG: NORA520 Dose 1|DRUG: NORA520 Dose 2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Grazoprevir (MK-5172) and Elbasvir (MK-8742) Combination for Chronic Hepatitis C Virus (HCV) Genotypes 1, 4, and 6 (MK-5172-065)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Grazoprevir + Elbasvir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Cohort Study for the Real - Life Effectiveness Evaluation of GlycOpyrronium With IndacatERol Combination in the Management of COPD in Canada (POWER Study)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Glycopyrronium /Indacaterol maleate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Booster Vaccine in Autoimmune Disease Non-Responders
Status: COMPLETED
Conditions: Rheumatoid Arthritis (RA)|Systemic Lupus Erythematosus (SLE)|Pemphigus Vulgaris|Multiple Sclerosis (MS)|Systemic Sclerosis (SSc)|Pediatric SLE|Juvenile Idiopathic Arthritis (JIA)|Juvenile Dermatomyositis (JDM)|Pediatric-Onset Multiple Sclerosis (POMS)
Interventions: BIOLOGICAL: Moderna mRNA-1273|BIOLOGICAL: BNT162b2|BIOLOGICAL: Ad26.COV2.S|DRUG: Continue IS (MMF or MPA)|DRUG: Continue IS (MTX)|BIOLOGICAL: Continue IS (B cell depletion therapy)|BIOLOGICAL: Monovalent [B.1.351] CoV2 preS dTM-AS03|DRUG: Withhold IS (MMF or MPA)|DRUG: Withhold IS (MTX)|DRUG: Withhold IS (B cell depletion therapy)|BIOLOGICAL: Moderna mRNA-1273, Bivalent|BIOLOGICAL: BNT162b2, Bivalent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Leptin for Abnormal Lipid Kinetics in HIV Lipodystrophy Syndrome
Status: COMPLETED
Conditions: HIV Lipodystrophy
Interventions: DRUG: Human recombinant leptin ("metreleptin")|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Label Phase I Dose Escalation Trial of Intravenous BI 6727 (Volasertib)in Combination With Oral BIBW 2992 (Afatinib) in Patients With Advanced Solid Tumours
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: BI 6727 + BIBW 2992
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Compare the Safety and Pharmacokinetics of YHP1604 in Comparison to the Co-administration of Telmisartan/Amlodipine and Rosuvastatin
Status: COMPLETED
Conditions: Hypertension|Hyperlipidemia
Interventions: DRUG: Temisartan/Amlodipine+Rosuvastatin|DRUG: YHP1604
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nurse Initiated Acupressure for Pain Management
Status: COMPLETED
Conditions: Pain, Postoperative|Pain, Acute
Interventions: DEVICE: Auricular acupressure|OTHER: Standard of care pain management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Epoprostenol for Injection (EFI/ACT-385781A) - Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: EFI/ACT-385781A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predicting Endoleaks Following Endovascular Aortic Aneurysm Repair Using 18F-Sodium Fluoride
Status: ACTIVE_NOT_RECRUITING
Conditions: Abdominal Aortic Aneurysm|Endoleak|Stent-Graft Endoleak
Interventions: DIAGNOSTIC_TEST: 18F Sodium Fluoride Positron Emission Tomography / Computed Tomography|DIAGNOSTIC_TEST: CT Aortic Angiogram|DIAGNOSTIC_TEST: 12-month CT Aortic Angiogram|OTHER: 24-month review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Prazosin in Preventing Post-traumatic Stress Disorder
Status: COMPLETED
Conditions: Acute Stress Disorder
Interventions: DRUG: Prazosin, ALPRESS® LP 2,5 et 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Safety and Effectiveness of Dupilumab for Treatment of Atopic Dermatitis (AD)
Status: COMPLETED
Conditions: Atopic Dermatitis (AD)
Interventions: DRUG: Dupilumab|DRUG: Placebo|OTHER: Background treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab and Ibrutinib in Treating Patients With Relapsed or Refractory Central Nervous System Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Central Nervous System B-Cell Non-Hodgkin Lymphoma|Recurrent Central Nervous System Lymphoma|Refractory Central Nervous System Lymphoma
Interventions: DRUG: Ibrutinib|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Progression of Myopia in Children Treated With Vitamin B2 and Outdoor Sunlight Exposure
Status: SUSPENDED
Conditions: Axial Myopia|Refractive Errors
Interventions: DRUG: Oral Riboflavin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Surgical Nivolumab And Ipilimumab For Recurrent GBM
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma|GBM|Glioblastoma Multiforme|Grade IV Astrocytoma
Interventions: DRUG: Nivolumab-Placebo|DRUG: Nivolumab|DRUG: Ipilimumab-Placebo|DRUG: Ipilimumab|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of OncoSil™ Given to Patients With Pancreatic Cancer Treated With Gemcitabine +/- Nab-paclitaxel.
Status: COMPLETED
Conditions: Unresectable Locally Advanced Pancreatic Carcinoma
Interventions: DEVICE: OncoSil™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Melatonin for Neuroprotection in Asphyxiated Newborns
Status: UNKNOWN
Conditions: Hypoxic-Ischemic Encephalopathy|Cell Damage|Asphyxia Perinatal
Interventions: DIETARY_SUPPLEMENT: Melatonin|OTHER: PLACEBO group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Milk Polar Lipids in Dyslipidemic Adults With Abdominal Obesity
Status: RECRUITING
Conditions: Dyslipidemias|Obesity
Interventions: DRUG: Milk Polar Lipid-Rich Dairy Powder|DIETARY_SUPPLEMENT: Dairy Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Post-Operative Analgesia After Percutaneous Nephrolithotomy.
Status: COMPLETED
Conditions: Pain|Postoperative Pain
Interventions: DRUG: Bupivacaine Hydrochloride 0.25% Injection. Paracetamol 650mg. Orphenadrine 50mg.|DRUG: paracetamol 1000mg. Tramadol 50mg. Dimenhydrinate 50mg.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT