pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety Study of Regimens of Sofosbuvir, GS-0938, and Ribavirin in Patients With Chronic Hepatitis C Infection
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Sofosbuvir|DRUG: GS-0938|DRUG: RBV|DRUG: Placebo to match sofosbuvir|DRUG: Placebo to match GS-0938
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of AK104 in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer Non-Small Cell Stage IIIB/IIIC/IV
Interventions: DRUG: AK104 plus Carboplatin and Pemetrexed|DRUG: AK104 plus Carboplatin and paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Von Willebrand Factor-platelet Aggregates in Patients With Type 2B Disease
Status: UNKNOWN
Conditions: Von Willebrand Disease, Type 2B
Interventions: PROCEDURE: 3T (Tesla) Magnetic Resonance Imaging (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase II Study of Nivolumab in Patients With Genetic Alterations in DNA Damage Repair and Response Who Progressed After Standard Treatment for Metastatic Solid Cancers
Status: UNKNOWN
Conditions: DDR Gene Mutation|Metastatic Solid Tumor
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Standard Treatment for Non-specific Low Back Pain Combined With Multimodal Osteopathy Treatment on Pain Intensity and Functional Capacity
Status: RECRUITING
Conditions: Low Back Pain
Interventions: OTHER: Standard treatment|OTHER: Osteopathy treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Total Neoadjuvant Treatment Plus PD-1 in Mid-Low Locally Advanced Rectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Tislelizumab|Locally Advanced Rectal Cancer|Total Neoadjuvant Treatment|PD-1
Interventions: DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robotic Transanal Specimen Extraction Surgery Versus Robotic Transabdominal Incision Specimen Extraction Surgery for Patients With Rectal Cancer: A Multicenter Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Rectal Neoplasms|Robotic Surgery|Natural Orifice Specimen Extraction Surgery
Interventions: PROCEDURE: Transanal specimen extraction robotic surgery|PROCEDURE: Transabdominal specimen extraction robotic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravascular ULTrasound Guided Versus Conventional Angiography Guided Strategy to Deploy Zotarolimus and Everolimus Eluting Third Generation Stents in the Long Coronary Artery Lesions: ULTRA-ZET Trial
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: IVUS guided percutaneous coronary angioplasty with Resolute integrity stent insertion|DEVICE: Angiography guided percutaneous coronary angioplasty with Resolute integrity stent insertion|DEVICE: Angiography guided percutaneous coronary angioplasty with Promus element stent implantation|PROCEDURE: Angiography guided percutaneous coronary angioplasty with Promus element stent implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2a Study of MVA-BN-RSV Vaccination and RSV Challenge in Healthy Adults
Status: COMPLETED
Conditions: RSV Infection
Interventions: BIOLOGICAL: MVA-mBN294B|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cryoablation as a Minimally Invasive Alternative to Surgery for Managing Ductal Carcinoma In Situ
Status: RECRUITING
Conditions: Ductal Carcinoma in Situ
Interventions: PROCEDURE: Cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Ponesimod Versus Teriflunomide In Relapsing MUltiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: ponesimod|DRUG: teriflunomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Observational Study Called ROVER to Learn More About How Well Vericiguat Works in People Who Were Newly Treated With Vericiguat in Routine Medical Care in Germany
Status: RECRUITING
Conditions: Chronic Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: Vericiguat (Verquvo, BAY1021189)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Safety and Efficacy of EGFR-TKI EGF816 in Combination With cMET Inhibitor INC280 in Adult Patients With EGFR Mutated Non Small Cell Lung Cancer.
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Capmatinib|DRUG: Nazartinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Skin Irritation of LEO 90100 Foam (Calcipotriol Hydrate Plus Betamethasone Dipropionate) in Healthy Japanese Subjects
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: LEO 90100 foam|DRUG: Vehicle of LEO 90100 foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of the Safety and Anesthetic Effect of AG-920 Topical Ophthalmic Solution
Status: COMPLETED
Conditions: Anesthesia, Local
Interventions: DRUG: AG-920|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dasatinib (BMS-354835) Versus Imatinib Mesylate in Subjects With Chronic Myeloid Leukemia
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia|Philadelphia-Positive Myeloid Leukemia
Interventions: DRUG: Dasatinib|DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Human Serum Albumin/Interferon alpha2a Fusion Protein Phase Ib Study in Chronic Hepatitis B Patients
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: BIOLOGICAL: Human Serum ALbumin/interferon alpha2a|BIOLOGICAL: Pegasys
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Pre-Anesthesia Evaluation Via Telemedicine Versus in Person for Surgical Patients at Moffitt Cancer Center
Status: ACTIVE_NOT_RECRUITING
Conditions: Gynecologic Cancer|Prostate Cancer|Patient Satisfaction
Interventions: BEHAVIORAL: Telemedicine|BEHAVIORAL: In Person Visit
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ankle-foot Orthoses for Night Splinting in Children With CP: Impact on Passive Stiffness in Plantarflexors Muscles
Status: WITHDRAWN
Conditions: Cerebral Palsy
Interventions: PROCEDURE: Wearing of night splint ankle foot orthoses (phase A)|PROCEDURE: No wearing of night splint ankle foot orthoses (phase B)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison the Hemodynamics Effects Between Dexmedetomidine and Propofol in Major Abdominal Surgical Patients
Status: UNKNOWN
Conditions: Abdominal Tumor|Intestinal Obstruction|Cirrhosis|Intestinal Fistula|Aneurism
Interventions: DRUG: dexmedetomidine|DRUG: propofol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Oblimersen in Treating Patients With Relapsed or Refractory Waldenstrom's Macroglobulinemia
Status: COMPLETED
Conditions: Waldenström Macroglobulinemia
Interventions: BIOLOGICAL: oblimersen sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Study to Evaluate Functional Outcome After Knee Replacement
Status: TERMINATED
Conditions: Osteoarthritis
Interventions: DEVICE: Off the Shelf Total Knee Replacement|DEVICE: ConforMIS iTotal Knee Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: CAR-T Cells Combined With Peptide Specific Dendritic Cell in Relapsed/Refractory Leukemia/MDS
Status: RECRUITING
Conditions: Leukemia, Acute Lymphocytic (ALL)|Leukemia, Acute Myelogenous (AML)|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: Chimeric antigen receptor T cells|BIOLOGICAL: peptide specific dendritic cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weaning Protocol for High Flow Nasal Cannula Oxygen Therapy
Status: COMPLETED
Conditions: High Flow Nasal Cannula|Respiratory Insufficiency
Interventions: DEVICE: Flow reduction first|DEVICE: FiO2 reduction first|DEVICE: Simultaneous (flow and FiO2) reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Evaluate the Clinical Efficacy of Probiotics in Patients With the Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DIETARY_SUPPLEMENT: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of a Large Increase in Dietary Fats and Cholesterol on HDL Composition and Function in Healthy Subjects
Status: COMPLETED
Conditions: Lipids
Interventions: DIETARY_SUPPLEMENT: Low fat/cholesterol diet|DIETARY_SUPPLEMENT: High fat/cholesterol diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Tofacitinib in Systemic Sclerosis
Status: RECRUITING
Conditions: Efficacy of Tofacitinib in the Systemic Sclerosis
Interventions: DRUG: Tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Nerve Root Axial Decompression Surgery in The Treatment of Tethered Cord Syndrome
Status: UNKNOWN
Conditions: Tethered Cord Syndrome
Interventions: BEHAVIORAL: Conservative treatment|PROCEDURE: Capsule surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gait Kinematics After Primary Total Knee Arthroplasty (TKA) Versus Revision TKA
Status: COMPLETED
Conditions: Knee Arthroplasty, Total|Gait Analysis
Interventions: DEVICE: Group primary TKA|DEVICE: Group TKA revision
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Relative Bioavailability Study of Sertraline HCl 100 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Sertraline HCl 100 mg tablets, single dose|DRUG: Zoloft® 100 mg tablets, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Study of the Effects of Desloratadine on Conjunctival Allergen Challenge-induced Ocular Signs and Symptoms (Study P04209)
Status: COMPLETED
Conditions: Conjunctivitis, Allergic
Interventions: DRUG: desloratadine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-coated Balloon Versus Conventional Balloon Angioplasty in Hemodialysis Graft
Status: UNKNOWN
Conditions: Vascular Graft Anastomotic Stenosis
Interventions: DEVICE: Conventional Balloon angioplasty|DEVICE: Drug-coated Balloon angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Control Trial to Assess Early Clinical and Functional Outcome of the ROCC and LCS Total Knee Implant Designs
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: LCS Knee|DEVICE: ROCC Knee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Single Dose of Long-acting Growth Hormone (Somapacitan) Compared to Daily Dosing of Norditropin® SimpleXx® in Children With Growth Hormone Deficiency
Status: COMPLETED
Conditions: Growth Hormone Disorder|Growth Hormone Deficiency in Children
Interventions: DRUG: somapacitan|DRUG: somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic Visbiome for Inflammation and Translocation in HIV Ι
Status: TERMINATED
Conditions: HIV-1 Infection
Interventions: DRUG: Visbiome|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation in Depression
Status: TERMINATED
Conditions: Major Depressive Disorder
Interventions: DRUG: Fecal microbiota capsules|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: tDCS Immediate Effect on Cardiorespiratory Parameters in Hemiparetics Adults Patients Due to Stroke.
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: tDCS active|DEVICE: tDCS Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Exenatide Plus Dapagliflozin on 24 Hour Glucose Variability Measured by CGM. A Proof of Concept.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Exenatide 2 MG|DRUG: Dapagliflozin 10 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dual Mobility Total Joint Prosthesis (Touch) for Thumb Carpometacarpal Joint Osteoarthritis
Status: UNKNOWN
Conditions: Rhizarthrosis
Interventions: DEVICE: Touch Dual Mobility CMC I Prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy, Mitomycin, and Either Fluorouracil or Cisplatin in Treating Patients With Locally Advanced Anal Cancer
Status: TERMINATED
Conditions: Anal Cancer
Interventions: DRUG: cisplatin|DRUG: fluorouracil|DRUG: mitomycin C|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Effect of Everolimus in Progression of Graft Vascular Illness on Patients With Heart Transplant
Status: UNKNOWN
Conditions: Cardiac Transplant
Interventions: DRUG: everolimus|DRUG: azathioprine or mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Pozelimab in Combination With Cemdisiran in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pozelimab|DRUG: Cemdisiran
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HeartLight X3 Endoscopic Ablation System With Excalibur Balloon for Treatment of Symptomatic Persistent AF
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: HeartLight X3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Efficacy of Blood Flow Restricted Training in Lateral Elbow Tendinopathy
Status: RECRUITING
Conditions: Lateral Epicondylitis|Tennis Elbow|Tendonitis Elbow
Interventions: OTHER: Blood flow restriction|OTHER: Multimodal rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Immediate Implant Placement With Immediate Provisionalization Into Extraction Sockets With Labial Plate Dehiscence Defects Within the Maxillary Esthetic Zone
Status: UNKNOWN
Conditions: Badly Decayed Anterior Maxillary Teeth
Interventions: DEVICE: immediate implant in defected anterior maxillary esthetic zone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention and Treatment Of Diabetes Complications With Gastric Surgery or Intensive Medicines
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: Best medical treatment|PROCEDURE: gastric bypass|PROCEDURE: sleeve gastrectomy|DRUG: General interventions for all groups: blood presure|DRUG: General interventions for all groups: dysilipidemia|BEHAVIORAL: General interventions for all groups: lifestyle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of SYMBICORT® pMDI With Formoterol Turbuhaler® in Subjects With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Budesonide/formoterol (SYMBICORT) pMDI|DRUG: Formoterol Turbuhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Evaluate the Safety and Immunogenicity of COVID-19 Vaccine
Status: RECRUITING
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: COVID-19 Vaccine (Vero Cell) ,Inactivated|BIOLOGICAL: COVID-19 mRNA Vaccine (ZSVG-02-O) 10 μg|BIOLOGICAL: COVID-19 mRNA Vaccine (ZSVG-02-O) 30 μg|BIOLOGICAL: COVID-19 mRNA Vaccine (ZSVG-02-O) 60 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Theta Burst Stimulation in Anorexia Nervosa
Status: UNKNOWN
Conditions: Anorexia Nervosa
Interventions: DEVICE: Intermittent Theta Burst Stimulation|DEVICE: Continuous Theta Burst Stimulation|DEVICE: Sham Theta Burst Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Macitentan/Tadalafil Combination Administered a Fixed-dose Combination Formulation Compared to the Reference Free Combination of Macitentan and Tadalafil
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: FDC of macitentan/tadalafil (10 mg/20 mg)|DRUG: Macitentan 10 mg|DRUG: Tadalafil 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Double-dose Furmonertinib in the Treatment of Patients With Slow Osimertinib-resistant NSCLC
Status: NOT_YET_RECRUITING
Conditions: Non Small Cell Lung Cancer|EGFR Gene Mutation|Non Small Cell Lung Cancer Stage IIIA|Non-small Cell Lung Cancer Stage IV
Interventions: DRUG: Furmonertinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Celebrex Premedication in Teeth With Symptomatic Irreversible Pulpitis
Status: UNKNOWN
Conditions: Pulpitis
Interventions: DRUG: Celebrex premedication|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Estimated Cumulative Incidence of Zika Infection at the End of the First Epidemic in the French West Indies in a Sample of Patients Followed for HIV Infection.
Status: TERMINATED
Conditions: HIV Infections|Zika Virus Infection
Interventions: OTHER: Biological sample collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: In Vitro Optimization of Oxytocin-induced Myometrial Contractility by Propranolol
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Oxytocin|DRUG: Propranolol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy of WELT-IP in Insomnia (WCTP-I-B-02)
Status: COMPLETED
Conditions: Insomnia
Interventions: DEVICE: WELT-IP|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Combination Grazoprevir (MK-5172)/Elbasvir (MK-8742) Versus Sofosbuvir + Pegylated Interferon + Ribavirin in Hepatitis C Virus Genotype 1, 4 or 6 Infection (MK-5172-077)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Sofosbuvir|BIOLOGICAL: PegIntron|DRUG: Ribavirin|DRUG: Grazoprevir/Elbasvir (100 mg/50 mg) FDC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blood Transfusion Applications in Hip Replacements
Status: COMPLETED
Conditions: Blood Transfusion|Hip Replacement|Anesthesia Management
Interventions: PROCEDURE: Anesthesia management/Hip replacement surgery|PROCEDURE: Demographic data|PROCEDURE: Chronic diseases|PROCEDURE: Postoperative complication
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease
Status: RECRUITING
Conditions: Dry Eye Disease
Interventions: DRUG: Reproxalap ophthalmic solution (0.25%)|DRUG: Vehicle ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics & Pharmacodynamics of Toripalimab for Patients With Recurrent Malignant Lymphoma
Status: COMPLETED
Conditions: Malignant Lymphoma
Interventions: BIOLOGICAL: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Statin as Neo-Adjuvant Therapy in Postmenopausal Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Postmenopausal
Interventions: DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab and Combination Chemotherapy With or Without Bleomycin Sulfate in Treating Patients With Primary Mediastinal Large B-Cell Lymphoma
Status: WITHDRAWN
Conditions: Lymphoma
Interventions: BIOLOGICAL: bleomycin sulfate|BIOLOGICAL: rituximab|DRUG: EPOCH regimen|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: prednisone|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sirolimus-Eluting BX VELOCITYTM Balloon-Expandable Stent in a Compassionate Use Registry (SECURE)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: CYPHER Sirolimus-Eluting Coronary Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Effect of Vonoprazan on Midazolam Pharmacokinetics in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Vonoprazan|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Decannulation Time: Limitation of Decannulation Capping Trials (REDECAP)
Status: COMPLETED
Conditions: Tracheostomy|Airway Management|Respiratory Therapy
Interventions: PROCEDURE: Decannulation protocol.|DEVICE: High flow conditioned oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Long Term Immunogenicity up to 10 Years After the First Booster Immunization With Tick Borne Encephalitis Vaccine in Adults Who Received 1 of 3 Different Primary Vaccination Schedules
Status: COMPLETED
Conditions: Tick Borne Encephalitis|Virus Diseases
Interventions: OTHER: Blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Pre-acclimatization Augmented Extreme Altitude Expedition
Status: ACTIVE_NOT_RECRUITING
Conditions: Altitude Hypoxia|Perfusion; Complications
Interventions: OTHER: Nitrogen tent preacclimatization to high altitude
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Preoperative Chemoradiotherapy With Cetuximab in Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Neoplasms|Neoadjuvant Treatment
Interventions: DRUG: Cetuximab, Irinotecan, Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Maintenance DCVAC/OvCa After First-line Chemotherapy Added Standard of Care
Status: RECRUITING
Conditions: Epithelial Ovarian Carcinoma|Fallopian Tube Carcinoma|Primary Peritoneal Carcinoma
Interventions: COMBINATION_PRODUCT: DCVAC/OvCa|COMBINATION_PRODUCT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Transcranial Random Noise (tRNS) for Early Alzheimer's Disease
Status: RECRUITING
Conditions: Transcranial Random Noise|Electroencephalography|Alzheimer Disease
Interventions: DEVICE: High frequency transcranial random noise|DEVICE: Sham high frequency transcranial random noise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Deep rTMS and Varenicline for Smoking Cessation
Status: COMPLETED
Conditions: Tobacco Use Disorder|Smoking Cessation
Interventions: DEVICE: Deep Repetitive Transcranial Magnetic Stimulation (Active)|DEVICE: Deep Repetitive Transcranial Magnetic Stimulation (Sham)|DRUG: Varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nurse-led Smoking Cessation With Further Follow-up in Lifestyle Centres - a Randomized Pilot Study
Status: COMPLETED
Conditions: Smoking Cessation|Smoking Behaviors|Nurse's Role|Cardiovascular Diseases
Interventions: BEHAVIORAL: behavioural and cessation aids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Tolerability of DS-7423 in Subjects With Advanced Solid Malignant Tumors
Status: COMPLETED
Conditions: Solid Tumor|Colorectal Cancer|Endometrial Cancer
Interventions: DRUG: DS-7423
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of a Gluten Free Food Guide on Diet Quality and Adherence to the GFD in Youth With Celiac Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Celiac Disease in Children|Gluten Enteropathy|Diet; Deficiency|Adherence, Treatment
Interventions: BEHAVIORAL: Gluten-free food guide teaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Determine the Safety and Effectiveness of Antiviral Combination Therapy to Treat Hepatitis C Virus (HCV) in Patients Who Have Previously Not Received the Standard of Care
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: PSI-7977|DRUG: Daclatasvir|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FCV vs VCV in Obstructive and Asthmatic Patients
Status: NOT_YET_RECRUITING
Conditions: Obstructive Pulmonary Disease|Mechanical Ventilation Pressure High|Asthma COPD
Interventions: DEVICE: FCV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Haploidentical Stem Cell Transplantation and IL-15 NK Cell Infusion for Paediatric Refractory Solid Tumours
Status: TERMINATED
Conditions: Childhood Solid Tumor
Interventions: OTHER: HAPLOIDENTICAL IL-15 STIMULATED NK CELLS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism
Status: RECRUITING
Conditions: Hypertrophy
Interventions: DIETARY_SUPPLEMENT: Krill oil|DIETARY_SUPPLEMENT: Krill protein|DIETARY_SUPPLEMENT: Vegetable oil|DIETARY_SUPPLEMENT: Carbohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of Risperidone in the Prevention of Relapse in Children and Adolescents With Conduct and Other Disruptive Behavior Disorders
Status: COMPLETED
Conditions: Attention Deficit and Disruptive Behavior Disorders
Interventions: DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Tele-rheumatology for Delivering High Quality Rheumatology Care During the COVID-19 Crisis (EVOLVE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Rheumatic Diseases
Interventions: OTHER: Tele-rheumatology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Clinical Trial Evaluating LX109 Gene Therapy in Patients With nAMD
Status: NOT_YET_RECRUITING
Conditions: To Evaluate the Safety and Tolerability of Intravitreal Injection of LX109 in Patients With nAMD
Interventions: DRUG: LX109
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: WALANT and Spinal Anesthesia Comparison of Clinical Result in Ankle Fractures
Status: RECRUITING
Conditions: Ankle Fractures
Interventions: PROCEDURE: WALANT in Ankle Fractures (Wide-Awake Local) Anesthesia No Tourniquet) and Applied Under Spinal Anesthesia Comparison of Clinical Results of Surgical Treatment;ANT Procedure comparation|PROCEDURE: Applied Under Spinal Anesthesia of Clinical Results of Surgical Treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Progressive Resistance Training Combined With Traditional Physical Therapy in Patients With Shoulder Impingement Syndrome
Status: RECRUITING
Conditions: Shoulder Impingement Syndrome
Interventions: PROCEDURE: Progressive resistance training|PROCEDURE: Traditional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Masitinib for the Treatment of Severe Mast Cell Activation Syndrome
Status: RECRUITING
Conditions: Mast Cell Activation Syndrome
Interventions: DRUG: Masitinib 4.5 mg/kg/day|DRUG: Placebo|OTHER: Best supportive care|DRUG: Masitinib 6.0 mg/kg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bovine Lactoferrin to Prevent and Cure Iron Deficiency and Iron Deficiency Anemia in Complicated Pregnancies
Status: COMPLETED
Conditions: Pregnancy|Iron Deficiency|Iron Deficiency Anemia
Interventions: DIETARY_SUPPLEMENT: Lattoglobina (Grunenthal) containing bLf|DRUG: FerroGrad by Abbott
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Two Somatropin Products (Norditropin® Versus Genotropin®) in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Genetic Disorder|Prader-Willi Syndrome|Growth Disorder|Idiopathic Short Stature|Healthy
Interventions: DRUG: somatropin|DRUG: somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing the Safety and Efficacy of Cethromycin to Clarithromycin for the Treatment of Community-Acquired Pneumonia
Status: COMPLETED
Conditions: Pneumonia
Interventions: DRUG: Cethromycin|DRUG: Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stroke and Panorama - Analyzing Carotid Endocalcifications (SPACE)
Status: COMPLETED
Conditions: Carotid Stenoses
Interventions: OTHER: Carotid ultrasound examination|OTHER: Panorama examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial on Metoclopramide and Ketoprofen in Acute Migraine of Childhood
Status: WITHDRAWN
Conditions: Migraine
Interventions: DRUG: metoclopramide|DRUG: placebo|DRUG: ketoprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Active Prevention of MSDs (Musculoskeletal Disorders, Upper and Spine Members) in the Context of Computer Screen Work
Status: COMPLETED
Conditions: Symptomatic Musculoskeletal Diseases|Latent Musculoskeletal Diseases
Interventions: BEHAVIORAL: Computer program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Effect of a Infection Control Program on the Reduction of Bacterial Contamination on NG Tube Feeding in RCHEs
Status: UNKNOWN
Conditions: Infection, Bacterial
Interventions: OTHER: Multimodal Infection control programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of Campath in Nonmyeloablative Transplantation
Status: COMPLETED
Conditions: Lymphoma|Leukemia
Interventions: DRUG: Campath-1 H (Alemtuzumab)|DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraperitoneal RIT With 131I-8H9 for Pts With DSRCT and Other Solid Tumors Involving the Peritoneum
Status: TERMINATED
Conditions: Peritoneal Cancer
Interventions: BIOLOGICAL: 131 I-8H9
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Manual Lymphatic Drainage and Therapeutic Ultrasound on Breast Engorgement in Postpartum Women
Status: RECRUITING
Conditions: Breast Engorgement|Lactation Disorders
Interventions: OTHER: Manual Lymphatic Drainage Group|OTHER: Ultrasound therapy group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inflammation and Coronary Artery Disease: Role of AT1-Receptor Antagonism
Status: COMPLETED
Conditions: Hypertension|Coronary Arteriosclerosis
Interventions: DRUG: telmisartan 40 mg|DRUG: placebo 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Interest in Using Ultrasound Fusion in Percutaneous Interventional Radiology
Status: COMPLETED
Conditions: Tissular Lesion
Interventions: DEVICE: Ultrasound fusion guiding system - TUS A-500 (Aplio 500)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Histological Evaluation of Human Skin Bx to Assess the Effects of APR Tx as an Adjunct Procedure in Facelift Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Skin Laxity|Tissue Degeneration|Tissue Breakdown|Collagen Degeneration|Collagen Shrinkage
Interventions: DEVICE: Renuvion APR System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: US Clinical Study of the Apnex Medical Hypoglossal Nerve Stimulation (HGNS) System to Treat Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: HGNS Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sidlenafil in Combination With Oral Anticoagulants in Patients With Intermediate-high Risk of Pulmonary Embolism
Status: UNKNOWN
Conditions: Pulmonary Embolism|Intermediate-high Risk|Combination of Oral Anticoagulation Therapy and Sildenafil
Interventions: DRUG: Sildenafil/apixaban|DRUG: apixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Dietary Supplementation of Diamine Oxidase to Improve Symptoms in Patients With IBS
Status: NOT_YET_RECRUITING
Conditions: Irritable Bowel Syndrome (IBS)
Interventions: DRUG: DAO supplement|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Revlimid®, Oral Cyclophosphamide and Prednisone for Patients With Newly Diagnosed Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: lenalidomide (Revlimid®)|DRUG: Cyclophosphamide|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Galvanic Vestibular Stimulation on Cortical Excitability and Hand Dexterity in Multiple Sclerosis Patients
Status: RECRUITING
Conditions: Cortical Excitability|Multiple Sclerosis
Interventions: DEVICE: Galvanic vestibular stimulation|DEVICE: MovAlyzeR® software from Neuroscript|DEVICE: BODYFIT Mini Portable Pedal Home Exerciser (cyclic ergometer)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Wearables to Define Postpartum Blood Pressure Trajectories and Facilitate Evidence-based Monitoring Guidelines
Status: ENROLLING_BY_INVITATION
Conditions: Hypertension, Pregnancy-Induced|Hypertension|Postpartum Preeclampsia|Postpartum Complication|Postpartum Pre-Eclampsia|Cardiovascular Diseases|Cardiovascular Morbidity|Morbidity;Perinatal
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mifepristone for Breast Cancer Patients With Higher Levels of Progesterone Receptor Isoform A Than Isoform B.
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Mifepristone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RoboHear™ Device: Advanced Haptic Technology That Allows the Deaf to Understand Speech
Status: WITHDRAWN
Conditions: Hearing Impairment|Deafness
Interventions: DEVICE: RoboHear Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Vitamin D and Microbiota in Cystic Fibrosis
Status: COMPLETED
Conditions: Vitamin D Deficiency|Cystic Fibrosis
Interventions: DIETARY_SUPPLEMENT: High-Dose Vitamin D3|OTHER: Stool Sample|OTHER: Sputum Sample|OTHER: Sham Comparator|PROCEDURE: Blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Conventional Nissen Fundoplication Versus Laparoscopic Nissen Fundoplication
Status: COMPLETED
Conditions: GERD
Interventions: PROCEDURE: Laparoscopic Nissen fundoplication|PROCEDURE: Open Nissen fundoplication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lipid Lowering Effect of Plant Stanol Ester in a Spoonable Non-dairy Product
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: OTHER: Product that contains plant stanol ester|OTHER: Placebo product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antipsychotic Induced Hyperprolactinemaia as Risk Factor for Periodontitis in Schizophrenic Patients
Status: COMPLETED
Conditions: Schizophrenia Spectrum and Other Psychotic Disorders|Periodontal Diseases
Interventions: DRUG: antipsychotic drugs inducing hyperprolactinemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Giredestrant (GDC-9545) in Postmenopausal Women With Stage I-III Operable, Estrogen Receptor-Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Giredestrant|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Short Term Atorvastatin Treatment,80mg/Day on Early Regression of Carotid Artery Atherosclerotic Lesions
Status: UNKNOWN
Conditions: Atherosclerosis
Interventions: DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prostate SBRT for Locally Recurrent Prostate Cancer After Prior Radiotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer|Prostatic Neoplasm
Interventions: DRUG: 18F-DCFPyL|RADIATION: Tumor Irradiation|RADIATION: Prostate + tumor irradiation|RADIATION: Tumor Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Swedish BioFINDER - Preclinical AD Study
Status: RECRUITING
Conditions: Alzheimer Disease|Mild Cognitive Impairment|Mild Dementia
Interventions: DIAGNOSTIC_TEST: Plasma tau|DIAGNOSTIC_TEST: Plasma Ab42/Ab40|DIAGNOSTIC_TEST: Flutemetamol F18 Injection|DIAGNOSTIC_TEST: [18F]-RO6958948 Injection|DIAGNOSTIC_TEST: Magnetic resonance imaging (MRI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pharmacokinetic Study of Padsevonil in Study Participants With Either Normal or Moderately Impaired Hepatic Function
Status: TERMINATED
Conditions: Healthy Study Participants|Impaired Hepatic Function
Interventions: DRUG: Padsevonil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Open Label Extension Trial of Eculizumab in Relapsing NMO Patients
Status: COMPLETED
Conditions: Neuromyelitis Optica|Neuromyelitis Optica Spectrum Disorder
Interventions: BIOLOGICAL: eculizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tamoxifen Treatment in Patients With Motor Neuron Disease
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis|ALS Functional Ration Scale|TAR-DNA-binding Protein-43|Tamoxifen|mTOR
Interventions: DRUG: tamoxifen 40 mg daily for one year
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Abuse Liability of an Abuse-Deterrent Immediate-Release Formulation (ADAIR)
Status: COMPLETED
Conditions: ADHD|Narcolepsy
Interventions: DRUG: ADAIR 10mg IR capsules|DRUG: Crushed d-amphetamine sulfate IR tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Cutaneous Xylocaine Spray to Reduce Intravenous Cannulation Pain in Adults
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Xylocaine spray|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dose Escalation of Bivatuzumab Mertansine in Patients With Advanced Squamous Cell Carcinoma of the Head and Neck or Esophagus
Status: TERMINATED
Conditions: Carcinoma, Squamous Cell
Interventions: DRUG: bivatuzumab mertansine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computer Navigation vs Conventional Technique in Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Osteoarthritis|Rheumatoid Arthritis
Interventions: PROCEDURE: Computer navigated knee replacement|PROCEDURE: Conventional knee replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT