pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Systems Support Mapping in Guiding Self-Management in Stage I-III Colorectal Cancer Survivors
Status: COMPLETED
Conditions: Cancer Survivor|Stage I Colorectal Cancer AJCC v8|Stage II Colorectal Cancer AJCC v8|Stage IIA Colorectal Cancer AJCC v8|Stage IIB Colorectal Cancer AJCC v8|Stage IIC Colorectal Cancer AJCC v8|Stage III Colorectal Cancer AJCC v8|Stage IIIA Colorectal Cancer AJCC v8|Stage IIIB Colorectal Cancer AJCC v8|Stage IIIC Colorectal Cancer AJCC v8
Interventions: OTHER: Interview|OTHER: Questionnaire Administration|BEHAVIORAL: System Support Mapping
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Polyprev: Study to Compare Fecal Immunochemical Test With Endoscopic Surveillance After Advanced Adenoma Resection in Fecal Immunochemical Test Colorectal Cancer Screening Programs.
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: Annual FIT|PROCEDURE: Endoscopic surveillance.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Effect of Exercise on Cognitive Function and Mental Health in Heroin Addicts
Status: COMPLETED
Conditions: Unspecified Symptoms and Signs Involving Cognitive Functions Following Unspecified Cerebrovascular Disease|Heroin Addicts|Executive Function|Negative Thinking/Affect
Interventions: BEHAVIORAL: Aerobic exercise; Resistance exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate [18F]-FDG PET (Fluorodeoxyglucose-positron) in Patients With Pancreatic Cancer (MK-0000-144)
Status: TERMINATED
Conditions: Advanced Pancreatic Adenocarcinoma
Interventions: PROCEDURE: Comparator: [18F]-FDG PET/CT and Volumetric CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Zoledronic Acid Administered Monthly Versus Every 3 Months in Multiple Myeloma and Breast Cancer Patients Who Were Treated With Zoledronic Acid the Prior Year
Status: COMPLETED
Conditions: Multiple Myeloma|Breast Cancer
Interventions: DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RF and PEMF for Treatment of Vaginal Laxity and Mons Pubis and Labia for Improvement of Skin Laxity
Status: COMPLETED
Conditions: Vulvovaginal Atrophy|Menopause|Menopause Surgical
Interventions: DEVICE: Vulvovaginal Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: CD19-targeted CAR T Cells for Relapsed and Refractory (R/R) Mantle Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: BIOLOGICAL: CD19-targeted Chimeric Antigen Receptor (CAR) T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Warfarin and Antiplatelet Therapy in Chronic Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Warfarin titrated to an INR of 2.5-3.0|DRUG: Aspirin|DRUG: Clopidogrel 75
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Standard Noninvasive Positive Pressure Ventilation (NIPPV) and Low Expiratory Pressure NIPPV in ALS Patients
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DEVICE: Viasys® Healthcare, Pulmonetic Systems, lap-top ventilator (LTV machine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Renin-Angiotensin System in Essential Hypertension
Status: TERMINATED
Conditions: Hypertension
Interventions: DRUG: Enalapril 20 mg bd|DRUG: Candesartan 8 mg bd
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Treatment of Patients With Major Depressive Disorder With MK0869 (0869-066)(COMPLETED)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: aprepitant|DRUG: Comparator: paroxetine HCL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quality of Life in Patients Who Are Receiving Either Vinorelbine, Gemcitabine, and Docetaxel or Paclitaxel and Carboplatin for Advanced Non-Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: PROCEDURE: quality-of-life assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: BioHPP Hybrid Prosthesis Versus BioHPP Bar Implant Supported and Retained Overdenture Rehabilitating Edentulous Mandible
Status: COMPLETED
Conditions: Marginal Bone Loss|Patient Satisfaction
Interventions: PROCEDURE: surgical ( implants placement)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Fish Oils With Dairy or Plant Based Lipids on Mitochondrial and Physical, and Cognitive Function, in Elderly Humans
Status: TERMINATED
Conditions: Ageing|Mitochondrial Function|Physical Function|Cognitive Function
Interventions: DIETARY_SUPPLEMENT: Fish oils and dairy fat|DIETARY_SUPPLEMENT: Fish oils and plant fat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nasal Intermittent Positive Pressure Ventilation During Neonatal Intubation
Status: COMPLETED
Conditions: Respiratory Distress Syndrome|Intubation; Difficult or Failed|Newborn Morbidity|Desaturation of Blood|Ventilator Lung; Newborn
Interventions: DEVICE: Nasal intermittent positive pressure ventilation (NIPPV) via binasal cannula during neonatal intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nab-Paclitaxel Combined With Gemcitabine Adjuvant Chemotherapy After Radical Resection of Intrahepatic Cholangiocarcinoma
Status: UNKNOWN
Conditions: Cholangiocarcinoma, Intrahepatic
Interventions: DRUG: combined therapy using nab-paclitaxel and gemcitabine chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Noninvasive High Frequency Oscillatory Ventilation on Improving Carbon Dioxide Clearance in AECOPD Patients
Status: UNKNOWN
Conditions: COPD|Non-invasive Ventilation
Interventions: DEVICE: Non-invasive high-frequency oscillatory ventilation|DEVICE: Noninvasive Bilevel Positive Pressure Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study for p16+ Oropharyngeal Cancer PerSonalized De-escalation Treatment at University of MIchigan (CuSToMIze)
Status: RECRUITING
Conditions: Oropharyngeal Cancer|Squamous Cell Carcinoma of the Oropharynx
Interventions: PROCEDURE: Surgery|COMBINATION_PRODUCT: Chemoradiation|OTHER: Observation|RADIATION: Post-operative radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study of Sevoflurane Inhalation in Burn ICU Patients
Status: COMPLETED
Conditions: ICU Patients With Indication of Sedation
Interventions: DRUG: Short term sedation with sevoflurane in ICU
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of ALX-0081 Versus GPIIb/IIIa Inhibitor in High Risk Percutaneous Coronary Intervention (PCI) Patients
Status: COMPLETED
Conditions: Unstable Angina|Non ST Segment Elevation Myocardial Infarction (NSTEMI)|Stable Angina (Associated With High Risk PCI)
Interventions: DRUG: ALX-0081|DRUG: ReoPro®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Partner-Specific HIV Risk Reduction Intervention for Drug-Using Adolescents
Status: COMPLETED
Conditions: Sexually Transmitted Diseases|Substance-Related Disorders
Interventions: BEHAVIORAL: Partner-Specific IMB-based HIV risk reduction intervention|BEHAVIORAL: Healthy Lifestyle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neutralizing Power of Anti-SARS-CoV-2 (Anti-COVID-19) Serum Antibodies
Status: RECRUITING
Conditions: COVID-19|SARS CoV 2 Infection
Interventions: OTHER: Collection of biological samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Repotrectinib in Combination With Other Anticancer Therapies for the Treatment of Subjects With KRAS-Mutant Solid Tumors
Status: TERMINATED
Conditions: KRAS Mutation-Related Tumors|Metastatic Solid Tumor|Advanced Solid Tumor
Interventions: DRUG: TPX-0005|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serplulimab for Patients With Non-small Cell Lung Cancer (NSCLC) With TPS ≥ 50%: a Prospective, Single-center, Single-arm Phase 2 Study.
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer|PDL1 Gene Mutation
Interventions: DRUG: Serplulimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Low-Level Tragus Stimulation on Heart Rate Variability, Neutrophil-Lymphocyte Ratio, and Major Adverse Cardiovascular Events in Patients With ST-Segment Elevation Myocardial Infarction (TESLA-STEMI)
Status: RECRUITING
Conditions: ST Elevation Myocardial Infarction
Interventions: DEVICE: Parasym Neuromodulation Device (Treatment Group)|DEVICE: Parasym Neuromodulation Device (Sham Group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Eprotirome in HeFH Patients Who Are on Optimal Standard of Care
Status: TERMINATED
Conditions: Heterozygous Familial Hypercholesterolaemia
Interventions: DRUG: Placebo|DRUG: Eprotirome|DRUG: Eprotirome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing Docetaxel Plus Fulvestrant With Docetaxel in Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Stem Cell Transplant Followed By Maintenance Therapy in Treating Elderly Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Extramedullary Plasmacytoma|Isolated Plasmacytoma of Bone|Light Chain Deposition Disease|Primary Systemic Amyloidosis|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma
Interventions: DRUG: dexamethasone|DRUG: cisplatin|DRUG: doxorubicin|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: bortezomib|DRUG: thalidomide|DRUG: melphalan|PROCEDURE: autologous stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of the Effectiveness of e-IMCI Implementation in Primary Health Care Clinics in South Africa.
Status: COMPLETED
Conditions: Child Health|Clinical Practice Guidelines|Primary Health Care
Interventions: BEHAVIORAL: electronic IMCI|BEHAVIORAL: paper IMCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnesium Sulfate in Adductor Canal Blocks
Status: COMPLETED
Conditions: Knee Arthroplasty
Interventions: DRUG: Magnesium Sulfate|DRUG: Ropivacaine|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Levocetirizine Oral Solution
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial and Seasonal
Interventions: DRUG: Levocetirizine|DRUG: Cetirizine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: High Resolution Virtual Chromoendoscopy Versus Seattle Protocol for the Surveillance of Barrett's Esophagus
Status: RECRUITING
Conditions: Barrett Esophagus
Interventions: PROCEDURE: Electronic chromoendoscopy|PROCEDURE: White light endoscopy with Seattle protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pilot Study of the Thrombopoietin-Receptor Agonist Eltrombopag in Refractory Aplastic Anemia Patients
Status: COMPLETED
Conditions: Anemia, Aplastic|Anemia, Hypoplastic|Thrombocytopenia
Interventions: DRUG: Eltrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Relationship Between Magnetic Resonance Imaging (MRI) Scores and Sensory Testing in Axial Spondyloarthritis
Status: COMPLETED
Conditions: Central Sensitisation|Axial Spondyloarthritis|Inflammation
Interventions: DIAGNOSTIC_TEST: Pressure pain threshold|DIAGNOSTIC_TEST: Central Sensitization Inventory|OTHER: Spondyloarthritis Research Consortium of Canada scoring system|DIAGNOSTIC_TEST: Temporal Summation|DIAGNOSTIC_TEST: Conditioned pain modulation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Long-term Open-label Study of Botulinumtoxin Type A to Treat Spasticity of Leg(s) or Leg(s) and Arm in Cerebral Palsy
Status: COMPLETED
Conditions: Lower Limb and Combined Lower Limb and Upper Limb Spasticity Due to Cerebral Palsy
Interventions: DRUG: IncobotulinumtoxinA (16-20 Units per kg body weight)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between Micro Plate Fixation and Blocking k.Wire in Management of Acute Bony Mallet Finger : Randomized Controlled Clinical Trial Study
Status: RECRUITING
Conditions: Acute Bony Mallet Finger
Interventions: PROCEDURE: surgical fixation of acute bony mallet finger
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety From a Recombinant Folding Variant of Bet v 1
Status: COMPLETED
Conditions: Allergy
Interventions: BIOLOGICAL: recombinant birch pollen allergen|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BEhavioral Health Stratified Treatment (BEST) Study for Youth With Intellectual and/or Developmental Disabilities (IDD)
Status: ENROLLING_BY_INVITATION
Conditions: Depression|Anxiety|Transition
Interventions: BEHAVIORAL: Adapted Teens Achieving Mastery over Stress (TEAMS) Treatment|BEHAVIORAL: Adapted Teens Achieving Mastery over Stress (TEAMS) Prevention|BEHAVIORAL: Adapted Competent Adulthood Transition with Cognitive-behavioral & Interpersonal Training (CATCH-IT)|OTHER: Strengthening Families|OTHER: Virtual psycho-educational discussion groups for caregivers and participants|OTHER: Maternal Child Health Bureau (MCHB) Care Coordination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Predictive Signature of Benralizumab Response
Status: RECRUITING
Conditions: Asthma; Eosinophilic|Severe Asthma
Interventions: DRUG: Benralizumab Prefilled Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Safety, Biodistribution, Radiation Dosimetry and Tumor Imaging Potential of [131I]-SGMIB Anti-HER2 VHH1 in Healthy Volunteers and Breast Cancer Patients
Status: COMPLETED
Conditions: Healthy Volunteers|Breast Cancer
Interventions: BIOLOGICAL: [131I]-SGMIB Anti-HER2 VHH1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Patient-centered Nutrition Care II: An E-health Supported Symptom Based Nutrition Intervention
Status: UNKNOWN
Conditions: Nutritional Status|Psychological Distress|Quality of Life|Weight Change, Body
Interventions: BEHAVIORAL: Intervention Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Role of Micro Nutrient Supplement in Improvement of the Sperm DNA Fragmentation
Status: COMPLETED
Conditions: Infertility, Male
Interventions: DIETARY_SUPPLEMENT: PROFortil|OTHER: Vitamin E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine if Pre- and Post- Operative TAP Catheters With Ropivacaine Versus Placebo Affects Anesthetic, Narcotic Dosing, and Pain Scores
Status: UNKNOWN
Conditions: Pain, Postoperative|Delirium|Anesthesia, Local
Interventions: DRUG: Ropivacaine HCL|DRUG: sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Medico-economic Evaluation of Strategies for the Lead Extraction of Implantable Defibrillator and Pacemakers
Status: UNKNOWN
Conditions: Prosthesis-Related Infections|Equipment Failure|Heart Failure|Arrhythmias|Thrombosis
Interventions: DEVICE: Laser sheath|BEHAVIORAL: Implantable Cardiac Device lead extraction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of Intraoperative Tranexamic Acid on Perioperative Bleeding In Craniotomies
Status: RECRUITING
Conditions: Brain Tumor|Bleeding
Interventions: DRUG: TRANEXAMIC ACID 1 G in 10 mL INTRAVENOUS INJECTION, SOLUTION|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Simplification From Protease Inhibitors to Raltegravir
Status: UNKNOWN
Conditions: HIV Infections
Interventions: DRUG: Raltegravir (Use RAL as a simplification strategy)|DRUG: Raltegravir (Use RAL as a simplification strategy)|DRUG: Raltegravir (Use RAL as a simplification strategy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Versus Interrupted Abdominal Wall Closure After Emergency Midline Laparotomy
Status: UNKNOWN
Conditions: Laparotomy|Hernia
Interventions: PROCEDURE: Interrupted sutures|PROCEDURE: Continuous sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determining the Glycemic Effects of Three Types of Spaghetti
Status: COMPLETED
Conditions: Potential Abnormality of Glucose Tolerance|Appetitive Behavior
Interventions: OTHER: Glucose as reference food|OTHER: White bread|OTHER: Regular spaghetti|OTHER: Whole wheat spaghetti|OTHER: High fibre - low carbohydrates spaghetti
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Longitudinal Incision Versus Cruciate Incision in the Construction of an End Colostomy
Status: UNKNOWN
Conditions: Colorectal Neoplasms|Parastomal Hernia|Colostomy Stoma
Interventions: PROCEDURE: construction of an end colostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PROmOting Gynecologic Cancer Patients With Frailty to Achieve Functional Recovery
Status: RECRUITING
Conditions: Malignant Female Reproductive System Neoplasm|Gynecologic Cancer|Gynecologic Neoplasm
Interventions: OTHER: Physical function assessment|OTHER: Self-reported Assessments and Questionnaires|PROCEDURE: Surgery (Standard of Care, Non-Interventional)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Galcanezumab in the Prevention of Episodic Migraine- the EVOLVE-1 Study
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Galcanezumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Real-World Assessment of Clinical Outcomes in Metastatic NSCLC Patients With MET Exon 14 Skipping Mutation and Brain Metastases Treated With Capmatinib
Status: COMPLETED
Conditions: Metastatic Non-Small Cell Lung Cancer
Interventions: DRUG: Capmatinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Atengenal and Astugenal in Diffuse, Intrinsic Pontine Glioma (DIPG)
Status: SUSPENDED
Conditions: Diffuse, Intrinsic Pontine Glioma
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy of ASP1128 (MA-0217) in Subjects at Risk for Acute Kidney Injury (AKI) Following Coronary Artery Bypass Graft (CABG) and/or Valve Surgery
Status: COMPLETED
Conditions: Acute Kidney Injury (AKI)
Interventions: DRUG: ASP1128|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY)
Status: COMPLETED
Conditions: Infection|Bone Neoplasms
Interventions: DRUG: 24-Hour Prophylactic Cefazolin* Antibiotic Regimen|DRUG: 5-Days Prophylactic Cefazolin* Antibiotic Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity and Safety of the Seasonal Flu Vaccine in Elderly and in SOT Recipients
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Single dose MUTAGRIP® influenza vaccine|DRUG: Double dose of MUTAGRIP® influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Diaphragmatic Ultrasound in Acute Hypoxic - Hypercapnic Respiratory Failure (ARF)
Status: COMPLETED
Conditions: Acute Hypoxic - Hypercapnic Respiratory Failure (ARF)
Interventions: DIAGNOSTIC_TEST: D-US ARF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Isolation of Human Recombinant Therapeutic Monoclonal Anti-Pseudomonas Antibodies
Status: RECRUITING
Conditions: Pseudomonas Aeruginosa|Multi-antibiotic Resistance
Interventions: BIOLOGICAL: Isolation of anti-Pseudomonas antibodies from type B lymphocytes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects and Mechanisms of Brief Mindfulness Meditation and Hypnosis for Pain
Status: RECRUITING
Conditions: Pain|Chronic Pain
Interventions: BEHAVIORAL: Mindfulness Meditation|BEHAVIORAL: Self-hypnosis|OTHER: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of a Testosterone Eye Drop for the Treatment of Meibomian Gland Dysfunction
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction
Interventions: DRUG: testosterone ophthalmic solution|DRUG: vehicle of testosterone ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Study in Healthy Male Volunteers Following the Administration of Pantoprazole and Rosuvastatin
Status: COMPLETED
Conditions: Drug Interaction Potentiation
Interventions: DRUG: Rosuvastatin, Pantoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Systemic and Topical Treatments for Rash Secondary to Erlotinib in Lung Cancer
Status: COMPLETED
Conditions: Rash
Interventions: DRUG: Minocycline|DRUG: Clindamycin 2% in hydrocortisone 1% lotion|DRUG: Erlotinib|DRUG: Topical clindamycin 2%, triamcinolone acetonide 0.1% soln
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Toxicity On Quality of Life in Older Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer
Status: UNKNOWN
Conditions: Stage I Ovarian Cancer AJCC v6 and v7|Stage IA Fallopian Tube Cancer AJCC v6 and v7|Stage IB Fallopian Tube Cancer AJCC v6 and v7|Stage IC Fallopian Tube Cancer AJCC v6 and v7|Stage II Ovarian Cancer AJCC v6 and v7|Stage IIA Fallopian Tube Cancer AJCC v6 and v7|Stage IIB Fallopian Tube Cancer AJCC v6 and v7|Stage IIC Fallopian Tube Cancer AJCC v6 and v7|Stage III Ovarian Cancer AJCC v6 and v7|Stage III Primary Peritoneal Cancer AJCC v7|Stage IIIA Fallopian Tube Cancer AJCC v7|Stage IIIB Fallopian Tube Cancer AJCC v7|Stage IIIC Fallopian Tube Cancer AJCC v7|Stage IV Fallopian Tube Cancer AJCC v6 and v7|Stage IV Ovarian Cancer AJCC v6 and v7|Stage IV Primary Peritoneal Cancer AJCC v7
Interventions: PROCEDURE: Assessment of Therapy Complications|DRUG: Carboplatin|BIOLOGICAL: Filgrastim|DRUG: Paclitaxel|OTHER: Pharmacological Study|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating the Safety and Efficacy of the Maurora® DES in ICAS
Status: RECRUITING
Conditions: Intracranial Arteriosclerosis|Stroke (CVA) or TIA
Interventions: DEVICE: Maurora® Sirolimus Eluting Stent System|DEVICE: APOLLO™ Intracranial Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Naloxone Hydrochloride Study for Relief of Pruritus in Patients With MF or SS Forms of CTCL
Status: TERMINATED
Conditions: Mycosis Fungoides|Lymphoma, T-Cell, Cutaneous|Sézary Syndrome
Interventions: DRUG: Naloxone Hydrochloride Lotion, 0.5%|DRUG: Placebo Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Melatonin and Zinc Administration on Cardinal Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Status: RECRUITING
Conditions: Chronic Fatigue Syndrome|Myalgic Encephalomyelitis
Interventions: DIETARY_SUPPLEMENT: melatonin plus zinc|OTHER: isomaltose and magnesium stearate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of IMC-1121B in Patients With Advanced Solid Tumors Not Responding To Standard Therapy
Status: COMPLETED
Conditions: Cancer
Interventions: BIOLOGICAL: IMC-1121B|BIOLOGICAL: 1121B|BIOLOGICAL: 1121B|BIOLOGICAL: 1121B|BIOLOGICAL: 1121B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atrial Fibrillation Ablation Versus Atrioventricular Nodal Ablation With Conduction System Pacing in Heart Failure
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation, Persistent|Heart Failure
Interventions: DEVICE: Conduction system pacing|PROCEDURE: Atrioventricular nodal ablation|PROCEDURE: Atrial fibrillation ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Power Toothbrush Use in Nursing Homes to Eliminate Mouth and Body Inflammation
Status: COMPLETED
Conditions: Periodontal Disease
Interventions: DEVICE: Rotating-oscillating Power Toothbrush|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Color Change of the Laser and Chemical Vital Whitening Method in the Teeth
Status: COMPLETED
Conditions: Color; Change Teeth, Posteruptive
Interventions: PROCEDURE: Laser Bleaching|PROCEDURE: Chemical Bleaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Transanal Versus Laparoscopic Total Mesorectal Excision For Rectal Cancer
Status: RECRUITING
Conditions: Rectal Neoplasms Malignant|Surgery
Interventions: PROCEDURE: TaTME|PROCEDURE: LpTME
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genicular Nerve and Intra-articular Radiofrequency Versus Platelet Rich Plasma Injection for Knee Osteoarthritis
Status: UNKNOWN
Conditions: Chronic Knee Osteoarthritis
Interventions: PROCEDURE: Pulsed radiofrequency (P-RF)|PROCEDURE: Platelet rich plasma (PRP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 5-HTP and Creatine for Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: 5-Hydroxytryptophan 100 MG|DRUG: Creatine monohydrate|DRUG: placebo matched to 5-HTP|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open-Label Extension Study to Evaluate the Safety of SD-101 Cream in Participants With Epidermolysis Bullosa
Status: TERMINATED
Conditions: Epidermolysis Bullosa
Interventions: DRUG: SD-101 dermal cream (6%)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgery With or Without Combination Chemotherapy in Treating Patients With Cancer of the Esophagus
Status: COMPLETED
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: DRUG: cisplatin|DRUG: fluorouracil|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Dietary Fiber on Glucose & Lipids in Non Insulin Dependent Diabetes Mellitus (NIDDM)
Status: COMPLETED
Conditions: Non-Insulin-Dependent Diabetes Mellitus
Interventions: OTHER: High Fiber and Moderate Fiber Diets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iscador® P (Mistletoe) Immunotherapy for Recurrent Osteogenic Sarcoma
Status: RECRUITING
Conditions: Osteogenic Sarcoma Recurrent
Interventions: DRUG: Iscador*P
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|Crohn Disease|Colitis, Ulcerative
Interventions: BIOLOGICAL: 13-valent pneumococcal conjugated vaccine (PCV13)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of a Primary Care Clinical Ultrasound Classroom
Status: COMPLETED
Conditions: ULTRASONOGRAPHY|PRIMARY CARE
Interventions: OTHER: Primary Care Clinical Ultrasound Classroom (AECAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Study on Dry Needling for Primary Dysmenorrhea and Its Preliminary Correlation With Acupoints
Status: RECRUITING
Conditions: Trigger Point Pain, Myofascial|Acupuncture|Primary Dysmenorrhea
Interventions: OTHER: TrP-DN and Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Smart Phone Technology to Support PrEP Uptake and Adherence
Status: COMPLETED
Conditions: HIV Prevention|PrEP|Adherence, Medication
Interventions: BEHAVIORAL: Use of smart phone technology to support medication adherence and uptake
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Tupler's Technique on Postpartum Diastasis Recti and Strength Recovery of Abdominal Muscles
Status: COMPLETED
Conditions: Diastasis Recti
Interventions: OTHER: Tupler technique|OTHER: conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: InSpace™ System in Comparison to Best Repair of Massive Rotator Cuff Tear
Status: TERMINATED
Conditions: Rotator Cuff Tear
Interventions: PROCEDURE: Best Repair of torn Rotator Cuff|DEVICE: InSpace™ system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ipilimumab in Treating Patients With Metastatic or Recurrent Human Papilloma Virus-Related Cervical Cancer
Status: COMPLETED
Conditions: Cervical Adenocarcinoma|Cervical Squamous Cell Carcinoma|Human Papillomavirus Infection|Recurrent Cervical Carcinoma|Stage IVA Cervical Cancer AJCC v6 and v7|Stage IVB Cervical Cancer AJCC v6 and v7
Interventions: BIOLOGICAL: Ipilimumab|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 12-Week Study to Assess the Efficacy Safety and Tolerability of Gemcabene in Subjects With Severe Hypertriglyceridemia
Status: COMPLETED
Conditions: Severe Hypertriglyceridemia|Mixed Dyslipidaemia
Interventions: DRUG: Gemcabene|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ranibizumab Intravitreal Injections Versus Dexamethasone Intravitreal Implant in Patients With Central Retinal Vein Occlusion (CRVO)
Status: COMPLETED
Conditions: Visual Impairment|Macular Edema|Central Retinal Vein Occlusion
Interventions: DRUG: Ranibizumab|DRUG: Dexamethasone implant and sham injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Tivozanib (AV-951) to Sorafenib in Subjects With Advanced Renal Cell Carcinoma
Status: COMPLETED
Conditions: Advanced Renal Cell Carcinoma
Interventions: DRUG: tivozanib (AV-951)|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testosterone and Growth Hormone for Bone Loss in Men
Status: COMPLETED
Conditions: Hypopituitarism|Hypogonadism|Growth Hormone Deficiency
Interventions: DRUG: Testosterone plus somatropin|DRUG: testosterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of PPI in Preventing Gastroesophageal Reflux Disease of Seafarers
Status: UNKNOWN
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: Esomeprazole Magnesium Enteric-coated Tablets|BEHAVIORAL: Lifestyle adjustment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Use of Positron Emission Tomography/Computed Tomography (PET/CT) to Assess Tumor Response to Neoadjuvant Treatment for Distal Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: DEVICE: PET/CT with FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Conivaptan for the Reduction of Cerebral Edema in Intracerebral Hemorrhage- A Safety and Tolerability Study
Status: COMPLETED
Conditions: Cerebral Hemorrhage|Cerebral Edema|Intracerebral Hemorrhage|Stroke
Interventions: DRUG: Conivaptan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cytochlor, Tetrahydrouridine, and External-Beam Radiation Therapy in Treating Patients With Cancer That Has Spread to the Brain
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: Cytochlor|DRUG: Tetrahydrouridine|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Caffeine, With and Without Biperiden, as a Maintenance Treatment for Cocaine Dependence
Status: UNKNOWN
Conditions: Cocaine Dependence
Interventions: DRUG: caffeine|DRUG: Biperiden|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pirtobrutinib (LY3527727 [LOXO-305]) Versus Placebo in Participants With Relapsing Multiple Sclerosis
Status: WITHDRAWN
Conditions: Relapsing Multiple Sclerosis|Multiple Sclerosis
Interventions: DRUG: Placebo|DRUG: Pirtobrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Inactivated, Split-Virion Influenza Vaccine Compared With Standard Fluzone Vaccine in Elderly Subjects
Status: COMPLETED
Conditions: Orthomyxoviridae Infection|Influenza|Myxovirus Infection
Interventions: BIOLOGICAL: Split, Inactivated, Trivalent Influenza Vaccine|BIOLOGICAL: Split, Inactivated, Trivalent Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bivalirudin PCI Registry in Heparin Induced Thrombocytopenia/Heparin Induced Thrombocytopenia and Thrombosis Syndrome (HIT/HITTS) Patients
Status: WITHDRAWN
Conditions: Heparin-Induced Thrombocytopenia|Heparin-induced Thrombocytopenia and Thrombosis Syndrome
Interventions: DRUG: bivalirudin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Early Preparation With Gonadotropin- Releasing Hormon (GnRh) Agonists Injection With Frozen-Thawed Embryo Transfer?
Status: UNKNOWN
Conditions: Infertility, Female
Interventions: DRUG: Triptorelin SR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tailored Internet-delivered Cognitive Behaviour Therapy for Symptoms of Depression and Comorbid Problems
Status: COMPLETED
Conditions: Depression|Anxiety Disorders
Interventions: BEHAVIORAL: Tailored Internet-delivered CBT|BEHAVIORAL: Non-tailored Internet-delivered CBT|BEHAVIORAL: Online discussion group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Myofascial Releasing on Neck Pain in Patients With Trigger Points
Status: COMPLETED
Conditions: Trigger Point Pain, Myofascial|Neck Pain
Interventions: OTHER: Myofascial Group|OTHER: Sham Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Long-term and Short-term Efficacy and Safety of Transplantation Autologous Bone Marrow Cells (BMCs) in Patients With the First STEMI (ST Segment Elevation Myocardial Infarction)
Status: UNKNOWN
Conditions: Vascular Diseases|Cardiovascular Diseases|Acute Myocardial Infarction
Interventions: PROCEDURE: Transplantation of BMMCs|PROCEDURE: Transplantation of CD 133+ cells|PROCEDURE: stenting of IRA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dextrose Containing Fluid and the Postoperative Nausea and Vomiting in the Gynecologic Laparoscopic Surgery
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: OTHER: dextrose solution|OTHER: saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel, Cyclophosphamide & Doxorubicin, Autologous Dendritic Cells & Surgery in Stage II/III Breast Cancer (Women)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: therapeutic autologous dendritic cells|DRUG: aromatase inhibition therapy|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: paclitaxel|DRUG: tamoxifen citrate|GENETIC: gene expression analysis|GENETIC: protein expression analysis|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: immunoenzyme technique|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|PROCEDURE: adjuvant therapy|PROCEDURE: biopsy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Carvedilol on Cardiotoxicity in Cancer Patients Submitted to Anthracycline Therapy
Status: RECRUITING
Conditions: Cancer
Interventions: DRUG: Carvedilol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence Study of Fexofenadine HCl 180 mg + Pseudoephedrine HCl 240 mg ER Tablets of Dr.Reddy's Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Fexofenadine HCl + Pseudoephedrine HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Binimetinib for People With Relapsed/Refractory BRAF Wild Type Hairy Cell Leukemia and Variant
Status: RECRUITING
Conditions: Hairy Cell Leukemia
Interventions: DRUG: binimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NeoVax + CDX-301 and Nivolumab or Pembrolizumab in Melanoma
Status: RECRUITING
Conditions: Melanoma|Metastatic Melanoma
Interventions: DRUG: CDX-301|BIOLOGICAL: NEOVAX|DRUG: Nivolumab|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of an Oral Contraceptive in Healthy Females
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: EV/DNG (Qlaira, BAY86-5027, SH T00658ID)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Adjuvant PD-1 Blockade for High-risk Stage-II dMMR/MSI-H Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer|Microsatellite Instability High
Interventions: DRUG: Tislelizumab|DRUG: Adjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Blood Levels of Albaconazole in Healthy Subjects Who Have Received a Single Dose of 400 mg Albaconazole as a Tablet Versus Albaconazole as a Capsule
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: Albaconazole tablet 400mg|DRUG: Albaconazole 100mg capsules, then albaconazole 400mg tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Modifications of Nutritional Intake Upon Reproductive Hormones in Normal Women
Status: COMPLETED
Conditions: Female Reproductive System Disorder
Interventions: OTHER: Clamp|OTHER: Hypercaloric diet|OTHER: Basal|OTHER: Isocaloric diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Education to Improve Pneumococcal Vaccine Uptake Among Older Adults
Status: NOT_YET_RECRUITING
Conditions: Pneumococcal Vaccine Uptake|Vaccination Willingness|Pneumococcal Vaccine Knowledge|Pneumococcal Vaccine Attitude
Interventions: OTHER: Web-based educational video on pneumococcal vaccination|OTHER: Reminder email to be vaccinated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Cardiovascular Magnetic Resonance for the Occluded Infarct-Related Artery Treatment
Status: TERMINATED
Conditions: Cardiovascular Diseases|Heart Diseases|Myocardial Infarction|Heart Failure
Interventions: DRUG: Beta adrenergic blockers|DRUG: Platelet inhibitors|DRUG: Statins|DRUG: ACE inhibitors and/or ARB and/or AA|PROCEDURE: PCI with stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT