pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Cape Town Young Women's Health CoOp
Status: COMPLETED
Conditions: Condomless Sex|Human Immunodeficiency Virus (HIV)|Sexually Transmitted Infections (STIs)|Alcohol and Drug Use|Violence and Victimization|Access and Linkage to Healthcare|Education Advancement
Interventions: BEHAVIORAL: Young Women's Health CoOp (YWHC)|BEHAVIORAL: Standard HTC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trifluridine/Tipiracil in Combination With Capecitabine and Bevacizumab in Metastatic Colorectal Cancer Patients.
Status: RECRUITING
Conditions: Colorectal Cancer Metastatic
Interventions: DRUG: Capecitabine|DRUG: Bevacizumab|DRUG: Trifluridine/Tipiracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stromal Cells for the Treatment of Patients With COVID-19.
Status: WITHDRAWN
Conditions: COVID-19 Pneumonia|COVID-19
Interventions: BIOLOGICAL: Mesenchymal stem cell|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Pregabalin on Shoulder Pain in Patients With Central Sensitization After Arthroscopic Rotator Cuff Repair
Status: NOT_YET_RECRUITING
Conditions: Rotator Cuff Tears|Central Sensitisation|Neuropathic Pain
Interventions: DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Assessment Of Myocardial Viability Based On CTA/MRI Hybrid Models
Status: COMPLETED
Conditions: Acute Myocardial Infarction|Myocardial Viability|Vulnerable Coronary Plaques|Coronary Stenosis|Myocardial Fibrosis
Interventions: DIAGNOSTIC_TEST: Speckle Tracking echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Study Evaluating the Performance of HEMOBLAST Bellows Compared to FLOSEAL Hemostatic Matrix in Cardiothoracic Operations
Status: COMPLETED
Conditions: Cardiothoracic Surgery
Interventions: DEVICE: HEMOBLAST Bellows|DEVICE: FLOSEAL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Early COVID-19 Convalescent Plasma in Patients Admitted for COVID-19 Infection
Status: COMPLETED
Conditions: Severe Acute Respiratory Syndrome Coronavirus 2
Interventions: BIOLOGICAL: COVID-19 convalescent plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Ventriloquist Puppet Method for Children Under The Inhaler Treatment
Status: RECRUITING
Conditions: Hospitalism in Children
Interventions: OTHER: Ventriloquist Puppet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Optimization of the Time and Dosage of Vemurafenib in BRAF Positive Juvenile Patients With Refractory Histiocytosis
Status: RECRUITING
Conditions: Histiocytosis
Interventions: DRUG: Vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Different Universal Adhesive Systems in Non-carious Cervical Lesions.
Status: UNKNOWN
Conditions: Non-carious Cervical Lesions
Interventions: DEVICE: Single Bond Universal|DEVICE: G-Premio Bond
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: QUILT-3.011 Phase 2 Yeast-Brachyury Vaccine Chordoma
Status: COMPLETED
Conditions: Chordoma
Interventions: OTHER: Placebo|BIOLOGICAL: GI-6301 Vaccine (Yeast- Brachyury)|RADIATION: Radiotherapy|DEVICE: wGT3X-BT Actigraph
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Involving Community-dwelling Older Adults in Activities in Relation to Meals
Status: COMPLETED
Conditions: Frail Older Adults
Interventions: BEHAVIORAL: A rehabilitation process involving collaborative goal setting with a case manager about managing own food and meals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy of Gaseous Nitric Oxide on Venous Stasis Leg Ulcers
Status: TERMINATED
Conditions: Venous Ulcers
Interventions: DRUG: Nitric Oxide - same dose 6 wks|DRUG: Nitric Oxide modified treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endotracheal Intubation Using Macintosh Laryngoscope, Glidescope, Airwayscope During Chest Compression With Adjustment Height of a Bed
Status: COMPLETED
Conditions: Tracheal Intubation|Cardiac Arrest
Interventions: DEVICE: Macintosh laryngoscope|DEVICE: Glidescope|DEVICE: Airwayscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Confirmatory Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)
Status: COMPLETED
Conditions: Spinocerebellar Degeneration
Interventions: DRUG: KPS-0373, High dose|DRUG: KPS-0373, Low dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality for Anxiety and Pain Management During Oocyte Retrieval in IVF/ICSI Treatment
Status: NOT_YET_RECRUITING
Conditions: IVF|Procedural Pain|Procedural Anxiety
Interventions: DEVICE: Virtual Reality glasses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Study to Assess the Efficacy and Safety of Vildagliptin in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tocilizumab in Combination With an Oral Contraceptive in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tocilizumab|DRUG: Ortho-Novum® 1/35
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Clinical Significance of Intravascular OCT-NIRAF
Status: NOT_YET_RECRUITING
Conditions: Cardiovascular Diseases|Coronary Artery Disease
Interventions: DEVICE: OCT-NIRAF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of SHR6390 in Combination With Letrozole or Anastrozole in Patients With HR Positive and HER2 Negative Advanced Breast Cancer
Status: UNKNOWN
Conditions: Advanced Breast Cancer
Interventions: DRUG: SHR6390 Tablets|DRUG: Placebo Tablets|DRUG: Letrozole or Anastrozole Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of an Alternate Mode of Providing Artificial Breaths to Children With Very Severe Pneumonia
Status: TERMINATED
Conditions: Acute Respiratory Distress Syndrome (ARDS)
Interventions: DEVICE: Airway Pressure Release Ventilation (APRV)|OTHER: Low-tidal volume ventilation|DRUG: Methylprednisolone|OTHER: Restrictive fluid therapy|DRUG: sedo-analgesia titration|OTHER: Protocolized early enteral nutrition|OTHER: Protocolized supportive care|OTHER: Biomarker Assay
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Cerebral-Respiratory Interaction During Spontaneous Breathing Ventilation in Neurosurgical Patients (CeRes-SB)
Status: UNKNOWN
Conditions: Mechanical Ventilation Complication|Neurological Complication|Respiratory Complication
Interventions: OTHER: Mechanically ventilated neurosurgical patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Fluid Resuscitation Protocol on the Incidence of Reoperation for Bleeding After Emergency Cardiopulmonary Bypass Grafting
Status: ACTIVE_NOT_RECRUITING
Conditions: Resternotomy
Interventions: OTHER: Assessment of reason for resternotomy|OTHER: Assessment of reason for avoidance of resternotomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: IDEntification of New Predisposition Genes in Differentiated THYroid Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Differentiated Thyroid Cancer|Thyroid Cancer, Nonmedullary
Interventions: GENETIC: WGS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Carboxymetyl Starch (Oozfix) on Preventing Postoperative Complication After Gastrectomy
Status: RECRUITING
Conditions: Stomach Neoplasm
Interventions: DRUG: Oozfix|DRUG: Greenplast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Pilot Therapeutic Trial Using Hydroxyurea in Type I Spinal Muscular Atrophy Patients
Status: COMPLETED
Conditions: Muscular Atrophy, Spinal
Interventions: DRUG: Hydroxyurea|DRUG: Placebo to match hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Long Term Study of Safety for Long Acting Injectable Risperidone in Patients With Schizophrenia or Schizoaffective Disorder.
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK, PD and Safety of Multiple Doses of V1512 Tablets in PD Patients Compared to Standard Levodopa/Carbidopa Oral Tablets
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: V1512|DRUG: V1512|DRUG: V1512 and Entacapone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of SAB-176 in Healthy Adult Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Influenza A H1N1
Interventions: BIOLOGICAL: SAB-176|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials
Status: RECRUITING
Conditions: Breast Cancer, NOS|CNS Primary Tumor, NOS|Cervical Cancer, NOS|Colorectal Cancer, NOS|Leukemia, NOS|Lymphoma, NOS|Miscellaneous Neoplasm, NOS|Non-Rhabdomyosarcoma Soft Tissue Sarcoma, NOS|Testicular Nonseminomatous Germ Cell Tumor, NOS|Thyroid Cancer, NOS|Melanoma|Bone Cancer, NOS
Interventions: OTHER: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Diabetic Patients With De Novo Native Coronary Artery Lesions
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: CYPHER sirolimus-eluting stent|DEVICE: uncoated Bx VELOCITY balloon-expandable stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endo-GIA Versus Endowrist Stapler in Intracorporeal Urinary Diversion in Robotic Assisted Radical Cystectomy
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: PROCEDURE: Endowrist|PROCEDURE: Endo-GIA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: B-lines Lung Ultrasound Guided ED Management of Acute Heart Failure Pilot Trial
Status: COMPLETED
Conditions: Heart Failure|Heart Failure Acute|Acute Cardiac Pulmonary Edema|Acute Cardiac Failure
Interventions: OTHER: LUS-guided strategy-of-care|OTHER: Usual Care|DRUG: Intravenous Loop Diuretic|DRUG: Vasodilator|DEVICE: Non invasive Ventilation (NIV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hyaluronic Acid and Amino Acid Gel Applied to the Alveolar Socket After Mandibular Third Molar Extraction
Status: COMPLETED
Conditions: Pain|Oral Surgery|Third Molar Extraction
Interventions: DEVICE: Aminogam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Three Different Aflibercept Regimens in Subjects With Diabetic Macular Edema (DME)
Status: COMPLETED
Conditions: Macular Edema
Interventions: DRUG: Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improved Ability to Cope With Everyday Life Through a Person-centered Training Program in Elderly Patients With Rheumatoid Arthritis - PEP-walk Study
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BEHAVIORAL: Person-centered high-intense training under supervision|BEHAVIORAL: Personalized exercise program to perform at home
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Ankle Proprioception Training in Type 2 Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathies
Interventions: OTHER: Proprioceptive neuromuscular facilitation|OTHER: conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Air Pollution and Climate Changes on the Epidemiology of Cardiovascular Disease
Status: COMPLETED
Conditions: Pollution; Exposure|Acute Coronary Syndrome|Chronic Coronary Insufficiency|Particulate Matter Inhalation Injury|Cardiovascular Diseases|Cardiovascular Risk Factor
Interventions: OTHER: Impact of air pollution and climate changes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate Reactogenicity and Immunogenicity of Revaccination With Adjuvanted Influenza Vaccine in Elderly Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluarix|BIOLOGICAL: adjuvanted influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Neuro RX Gamma for Amnestic Mild Cognitive Impairment (aMCI)
Status: RECRUITING
Conditions: MCI|Amnestic Mild Cognitive Disorder
Interventions: DEVICE: Neuro RX Gamma device|DEVICE: Sham Neuro RX Gamma device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Rollover Study for Zerit (Stavudine) ER Studies (-096, -099)
Status: COMPLETED
Conditions: HIV Infections|AIDS
Interventions: DRUG: stavudine, efavirenz, lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nimotuzumab in Combination With Cisplatin and Docetaxel for Patients With Advanced Non-small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Nimotuzumab and chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Investigate the Efficacy and Safety of Orally Administered SA001 in Patients With Dry Eye Syndrome.
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: SA001 Low dose|DRUG: SA001 Mid dose|DRUG: SA001 High dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of Armodafinil Treatment in Healthy Subjects With Excessive Sleepiness Associated With Jet Lag Disorder
Status: COMPLETED
Conditions: Excessive Sleepiness
Interventions: DRUG: armodafinil|DRUG: armodafinil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cannula-based Versus Needle-based Subcision for Posttraumatic Atrophic Facial Scars
Status: COMPLETED
Conditions: Scar; Atrophy
Interventions: PROCEDURE: cannula- based subcision|PROCEDURE: common- needle based subcision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Interest of the ANI in the Monitoring of Peroperative Analgesia in Bariatric Surgery
Status: COMPLETED
Conditions: Surgery|Obese
Interventions: DEVICE: To demonstrate the monitoring of perioperative analgesia|OTHER: Standard preoperative evaluation of analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of CKD-391
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DRUG: Atorvastatin10mg, Ezetimibe10mg|DRUG: Atorvastatin10mg, Ezetimibe placebo|DRUG: Atorvastatin20mg, Ezetimibe10mg|DRUG: Atorvastatin20mg, Ezetimibe placebo|DRUG: Atorvastatin40mg, Ezetimibe10mg|DRUG: Atorvastatin40mg, Ezetimibe placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reduction of Claustrophobia and Patient Motion After Training of MRI Personnel in Comfort TalkTM
Status: COMPLETED
Conditions: Claustrophobia|Complication of Diagnostic Procedure
Interventions: BEHAVIORAL: Comfort Talk®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bioavailability of Vitamin B12 in Bread Using Fermented Faba Bean as B12 Source in Healthy Volunteers (BeanBread)
Status: NOT_YET_RECRUITING
Conditions: Vitamin B12 Absorption
Interventions: OTHER: Vitamin B12 bread|OTHER: Control bread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics of BIBB 515 BS and Effect of Food After Oral Administration in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIBB 515 BS|OTHER: Standard breakfast (40 g fat)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) as Monotherapy in Participants With Previously-Treated Locally Advanced Unresectable or Metastatic Colorectal Cancer (MK-3475-164/KEYNOTE-164)
Status: COMPLETED
Conditions: Colorectal Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Carboxypeptidase-G2 (CPDG2) and Thymidine for the Management of Patients With Methotrexate Toxicity and Renal Dysfunction
Status: COMPLETED
Conditions: Kidney Diseases
Interventions: DRUG: carboxypeptidase-G2
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Connecting Emergency Departments With Community Services to Prevent Mobility Losses in Pre-frail & Frail Seniors
Status: UNKNOWN
Conditions: Elderly|Functional Status
Interventions: OTHER: Exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An OBServational Clinical Trial (SARA-OBS) in Sarcopenia and Sarcopenic Obesity in Patients Aged 65 Years and Over
Status: COMPLETED
Conditions: Sarcopenia|Gait Disorders in Old Age|Muscle Weakness
Interventions: OTHER: No Drug and no aspecific intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of CIK for Patients With Refractory Non-Hodgkin Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Lymphoma, Non-Hodgkin
Interventions: BIOLOGICAL: Cytokine-induced killer cells (CIK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EIS-12656 as Single Agent and in Combination in Patients With Specified Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Homologous Recombination Deficiency|HRR Deficiency
Interventions: DRUG: EIS-12656|DRUG: Olaparib|DRUG: Trastuzumab deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension Study of AG-348 in Adult Participants With Pyruvate Kinase Deficiency Previously Enrolled in AG-348-006 or AG348-C-007
Status: COMPLETED
Conditions: Pyruvate Kinase Deficiency
Interventions: DRUG: AG-348
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extension Study of Tocilizumab (Myeloma Receptor Antibody [MRA]) in Patients Completing Treatment in Tocilizumab Core Studies
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tocilizumab|DRUG: Disease-modifying anti-rheumatic drugs|DRUG: Non-steroidal anti-inflammatory drugs|DRUG: Oral corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Irinotecan With TAS102 and Bevacizumab for Patients With Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Liposomal irinotecan|DRUG: TAS102|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dexamethasone and Methylprednisolone on Pain, Swelling and Trismus After Third Molar Surgery
Status: COMPLETED
Conditions: Pain,|Edema,|Trismus
Interventions: DRUG: Dexamethasone|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Physical Exercise on Glucose Control in People With Prediabetes
Status: NOT_YET_RECRUITING
Conditions: PreDiabetes
Interventions: BEHAVIORAL: Aerobic training|BEHAVIORAL: Aerobic training plus resistance training|BEHAVIORAL: High intensive interval training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RDEA3170 Monotherapy in Subjects With Gout
Status: COMPLETED
Conditions: Gout
Interventions: DRUG: Placebo|DRUG: RDEA3170 5 mg|DRUG: RDEA3170 10 mg|DRUG: RDEA3170 12.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Long Term Treatment With Testosterone Undecanoate in Males With Hypogonadism
Status: COMPLETED
Conditions: Hypogonadism
Interventions: DRUG: Testosterone undecanoate (TU) - NebidoTM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of SR58611A in the Prevention of Depression Relapse in Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder|Major Depression
Interventions: DRUG: SR58611A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Conducting Annual Asthma Reviews Using Telehealthcare: Comparison With Standard Care (Face-to-face Consultations)
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: Telehealthcare
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Ixekizumab (LY2439821) in TNF Inhibitor Experienced Participants With Radiographic Axial Spondyloarthritis
Status: COMPLETED
Conditions: Spondyloarthritis
Interventions: DRUG: Ixekizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Descemet Membrane Endothelial Keratoplasty (DMEK)
Status: COMPLETED
Conditions: Corneal Dystrophies, Hereditary
Interventions: PROCEDURE: Descemet Membrane Endothelial Keratoplasty (DMEK)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-based Treatment for Patients Suffering From Severe Functional Somatic Disorders
Status: RECRUITING
Conditions: Bodily Distress Disorder Moderate|Bodily Distress Disorder Severe|Fibromyalgia|Chronic Fatigue Syndrome|Irritable Bowel Syndrome|Somatization
Interventions: BEHAVIORAL: "One step at a time"|BEHAVIORAL: "Get started"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pentoxifylline and Progression of Chronic Kidney Disease in Moderate-to-high Risk Patients
Status: COMPLETED
Conditions: Kidney Failure, Chronic
Interventions: DRUG: Pentoxifylline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Autogenous Demineralized Tooth Graft Versus Autogenous Bone Graft During Immediate Implant Placement in the Esthetic Zone.
Status: UNKNOWN
Conditions: Estetic Zone|Autogenous Tooth Graft|Autogenous Bone Graft|Immediate Implant|Jumping Gap|Crestal Bone Level
Interventions: PROCEDURE: the use of demineralized autogenous tooth graft in the jumping gap during immediate implant placement|PROCEDURE: the use of autogenous bone graft in the jumping gap during immediate implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Provincial Scale-up of Choose to Move (CTM) Phase 4
Status: ENROLLING_BY_INVITATION
Conditions: Aging|Physical Inactivity|Mobility Limitation|Loneliness|Social Isolation
Interventions: BEHAVIORAL: Choose to Move
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Spironolactone for Paroxysmal Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DRUG: Spironolactone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relaxing Environment to Lower Anxiety During Onabotulinum Toxin Chemodenervation of the Bladder
Status: RECRUITING
Conditions: Anxiety|Pain|Burnout, Professional
Interventions: BEHAVIORAL: Lavender aromatherapy sticker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of the Tolerance and Efficacy of Combined Use of Didanosine (2',3'-Dideoxyinosine; ddI) and Lentinan in HIV-Positive Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Lentinan|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effects of Atorvastatin on the Nitric Oxide-system in Patients With Non-diabetic Nephropathy
Status: COMPLETED
Conditions: Nephropathy|Cardiovascular Diseases
Interventions: DRUG: Atorvastatin|DRUG: Unikalk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Life Enhancing Activities for Family Caregivers (LEAF 2.0)
Status: ACTIVE_NOT_RECRUITING
Conditions: Caregivers
Interventions: BEHAVIORAL: LEAF Positive Emotion Intervention|OTHER: Emotion Reporting Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Community Interventions to Improve Iron and Iodine Status in Mother and Child Dyads in Northern Ghana
Status: COMPLETED
Conditions: Iron Deficiency (ID)|General Anemia|Iron Deficiency Anemia (IDA)
Interventions: BEHAVIORAL: Intervention Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: New Method of IUD Insertion During Cesarian Section
Status: RECRUITING
Conditions: Postpartum Contraception
Interventions: DEVICE: Copper T380 IUD ( Paragard 380 A ,CooperSurgical, Inc. © 2022) (classic technique)|DEVICE: Copper T380 IUD ( Paragard 380 A ,CooperSurgical, Inc. © 2022) ( New technique)|PROCEDURE: cesarian section
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Progrip Versus ProFlor: Two Fixation Free Devices for Laparoscopic Inguinal Hernia Repair
Status: ENROLLING_BY_INVITATION
Conditions: Hernia, Inguinal|Laparoscopic Surgery
Interventions: PROCEDURE: Proflor group|PROCEDURE: Progrip group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mapping Sound Propagation Through the Human Lung for Better Diagnosis
Status: TERMINATED
Conditions: Bronchomalacia|Asthma|Lung Neoplasms|Lung Diseases, Interstitial|Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: Lung sound transmission measurement|OTHER: Lung sound recording
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: BAY73-4506 Probe Substrate Study
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Regorafenib (Stivarga, BAY73-4506)|DRUG: Warfarin|DRUG: Omeprazole|DRUG: Midazolam|DRUG: Rosiglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-Operative Single Shot Rectus Sheath Block
Status: COMPLETED
Conditions: Bladder Neoplasm|Prostate Neoplasm|Pelvic Neoplasm|Urologic Neoplasms|Opioid Use|Anesthesia, Local|Pain, Postoperative
Interventions: PROCEDURE: Rectus sheath block|PROCEDURE: Bilateral rectus sheath catheter|DRUG: Patient controlled opioid analgesia (PCA)|PROCEDURE: Subcutaneous injection saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Symptom Management for Rural-Urban Cancer Survivors and Caregivers
Status: RECRUITING
Conditions: Cancer|Cancer Survivors|Informal Caregivers|Psychological Distress
Interventions: BEHAVIORAL: Adaptive Symptom Management and Survivorship Handbook (SMSH) and Telephone Interpersonal Counseling (TIP-C)|BEHAVIORAL: NCI Brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Computer Stop Order Alert to Prevent Concurrent Prescribing of Trimethoprim/Sulfamethoxazole and Warfarin
Status: TERMINATED
Conditions: Prescribers' Drug Orders
Interventions: DRUG: Trimethoprim/Sulfamethoxazole and Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Dexmedetomidine Versus Gabapentin Premedication on the Emergence Agitation After Rhinoplasty
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Dexmedetomidine|DRUG: Gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ranibizumab 0.5mg and 2.0mg to Treat Diabetic Macular Edema in Patients With Poor Response to Bevacizumab
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stand Down-Think Before You Drink: An RCT of a Mobile App for Hazardous Drinking With Peer Phone Support
Status: RECRUITING
Conditions: Alcoholism
Interventions: BEHAVIORAL: Stand Down app|BEHAVIORAL: Peer-Supported Stand Down|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Rising Dose Study of MK-6194 in Participants With Atopic Dermatitis (MK-6194-008)
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: BIOLOGICAL: MK-6194|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability and Immunogenicity of Recombinant Botulinum Vaccine A/B in Healthy Adults
Status: COMPLETED
Conditions: RECOMBINANT BOTULINUM VACCINE A/B
Interventions: BIOLOGICAL: rBV A/B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Prospective Evaluation of Glaucoma Subjects Treated With Two Second Generation iStents and One iStent Supra
Status: TERMINATED
Conditions: Glaucoma, Open-Angle
Interventions: DEVICE: G2 and G3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Community-based Resilience Program of Only-child Loss Parents
Status: TERMINATED
Conditions: Resilience,Psychological|Bereavement|Happiness
Interventions: BEHAVIORAL: Positive psychology therapy group|BEHAVIORAL: Resilience promotion therapy group|OTHER: Controlled routine activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of Exenatide on Sleep in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes|Sleep Disordered Breathing
Interventions: DRUG: Exenatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Glycopyrrolate for Moderate-to-severe Sialorrhea in Parkinson's Disease
Status: UNKNOWN
Conditions: Sialorrhea|Parkinson's Disease
Interventions: DRUG: Glycopyrrolate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Immunotherapy in Combination With Chemotherapy in HER2-negative Inflammatory Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Inflammatory Breast Cancer
Interventions: DRUG: Pembrolizumab Injection|DRUG: neoadjuvant EC-paclitaxel chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lurasidone HCl - A Long Term Phase 3 Study of Patients With Chronic Schizophrenia
Status: COMPLETED
Conditions: Chronic Schizophrenia
Interventions: DRUG: Lurasidone HC1|DRUG: Quetiapine XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: REdo Transcatheter Aortic VALVE Implantation for the Management of Transcatheter Aortic Valve Failure
Status: NOT_YET_RECRUITING
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: Any commercially available transcatheter aortic valve|PROCEDURE: Surgical explantation and aortic valve replacement|OTHER: Conservative management
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Evaluation of Alirocumab in Patients With Heterozygous Familial Hypercholesterolemia or High Cardiovascular Risk Patients With Hypercholesterolemia on Lipid Modifying Therapy (ODYSSEY JAPAN)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Placebo (for alirocumab)|DRUG: Alirocumab|DRUG: Lipid-Modifying Therapy (LMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of TPI ASM8 During a 14-Day Allergen Challenge
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: TPI ASM8|DRUG: TPI ASM8|DRUG: TPI ASM8
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Efficacy of Platelet Rich Plasma and Dry Needling in Management of Anterior Disc Displacement of Temporomandibular Joint
Status: UNKNOWN
Conditions: Temporomandibular Joint Disc Displacement
Interventions: PROCEDURE: Dry Needling|PROCEDURE: PRP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study to Evaluate the Safety and Immunogenicity of a Revaccination Dose of the RSVPreF3 OA Investigational Vaccine in Adults 60 Years and Older Who Participated in the RSV OA=ADJ-002 Study
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: RSVPreF3 OA investigational vaccine (GSK3844766A)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of A Hemodynamic-Guided Treatment Strategy to Improve Blood Pressure Control
Status: COMPLETED
Conditions: Hypertension
Interventions: OTHER: ICG-guided drug selection|OTHER: empirical drug selection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeted Silica Nanoparticles for Real-Time Image-Guided Intraoperative Mapping of Nodal Metastases
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Melanoma
Interventions: DRUG: fluorescent cRGDY-PEG-Cy5.5-C dots
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Proximal Contacts and Contours in Class II Composite Restoration With Pre-cured Composite Inserts Versus Contact Making Instrument Technique. A Randomized Control Clinical Trial.
Status: UNKNOWN
Conditions: Class 2 Dental Cavity
Interventions: PROCEDURE: precured composite insert technique|PROCEDURE: Contact making instrument|PROCEDURE: Incremental composite layering technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antibiotics and Gut Microbiota Among Newborn Infants
Status: COMPLETED
Conditions: Surgical Wound Infection|Infection; Cesarean Section|Complications; Cesarean Section
Interventions: DRUG: Cefuroxime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low or High Dose of Dexamethasone in Patients With Respiratory Failure by COVID-19
Status: COMPLETED
Conditions: Covid19|Corticosteroids
Interventions: DRUG: Dexamethasone high dose|DRUG: Dexamethasone low dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects and Safety of OPK-88004 Doses in Men With Signs and Symptoms of Benign Prostatic Hyperplasia (BPH)
Status: TERMINATED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: Group-1 (15mg, OPK-88004)|DRUG: Group-2 (25 mg,OPK-88004)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: In-School Evaluation of Bystander: A Game-Based Intervention for Sexual Violence Prevention
Status: COMPLETED
Conditions: Bystander Behavioral Intentions
Interventions: BEHAVIORAL: Bystander, a game-based bystander intervention program|BEHAVIORAL: Infection City, a game-based program about meningitis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Biomarkers in Predicting Response in Patients With Advanced Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer Treated on GOG-0172 or GOG-0182
Status: UNKNOWN
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Peritoneal Cavity Cancer
Interventions: GENETIC: gene expression analysis|GENETIC: polymorphism analysis|GENETIC: protein expression analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mannitol-induced Release of Copeptin in Healthy Adults and Patients With Polyuria-Polydipsia Syndrome (MARS Study)
Status: NOT_YET_RECRUITING
Conditions: Polyuria-polydipsia Syndrome|Arginine Vasopressin Deficiency|Primary Polydipsia
Interventions: DIAGNOSTIC_TEST: Mannitol Infusion (blinded)|DIAGNOSTIC_TEST: Placebo Infusion (blinded)|DIAGNOSTIC_TEST: Mannitol Infusion (open label)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vacuum Assisted Closure as a Treatment for Soft Tissue Injuries
Status: COMPLETED
Conditions: Fracture of Calcaneus, Pilon or Tibial Plateau
Interventions: PROCEDURE: Standard Wound Dressing|DEVICE: Vacuum Assisted Closure Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravascular Ultrasound-derived Assessment of Hemodynamically Negative Lesions in NSTEACS Patients
Status: RECRUITING
Conditions: Non-ST-segment Acute Coronary Syndrome
Interventions: PROCEDURE: FFR-guided PCI|DIAGNOSTIC_TEST: Intravascular ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Oxaliplatin and Xeloda and Cetuximab as First Line Treatment for Metastatic or Unresectable Gastric or Gastroesophageal Junction Cancer
Status: UNKNOWN
Conditions: Gastric Cancer|Esophageal Cancer
Interventions: DRUG: oxaliplatin, capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Transcranial Direct Current Stimulation (tDCS) in Accelerating Learning in a Healthy Older Population
Status: COMPLETED
Conditions: Associative Memory in Healthy Subjects
Interventions: DEVICE: Active tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Roux-En-Y Pouch Reconstruction Compared With Conventional Roux-En-Y Reconstruction on Health-Related Quality of Life in Patients Undergoing Total Gastrectomy for Adenocarcinoma
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: PROCEDURE: Roux-en-Y pouch reconstruction (RYP)|PROCEDURE: conventional Roux-en-Y reconstruction (RYC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DEVICE: TMS: single session intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal target in individuals with major depressive disorder, via MagVenture MagPro R30 device / Cool-DB80 A/P coil|DEVICE: SHAM (inactive) TMS stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluating Acid Reflux After Oesophageal Stenting Using Anti-reflux Stents
Status: RECRUITING
Conditions: Esophageal Cancer|Reflux, Gastroesophageal
Interventions: DEVICE: Anti-reflux oesophageal stent|DEVICE: Conventional oesophageal stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: iMagemHTT: FIH Evaluation of Novel Mutant Huntingtin PET Radioligands [¹¹C]CHDI-00485180-R and [¹¹C]CHDI-00485626
Status: TERMINATED
Conditions: Huntington Disease
Interventions: RADIATION: Radioligand [¹¹C]CHDI-00485180-R|RADIATION: Radioligand [¹¹C]CHDI-00485626
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Assess Drug Levels and Safety of BMS-986278 in Healthy Participants and Participants With Different Degrees of Hepatic Impairment
Status: RECRUITING
Conditions: Hepatic Impairment|Healthy Participants
Interventions: DRUG: BMS-986278
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT