pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Brainstem and Prematurity
Status: COMPLETED
Conditions: Very Premature Infants
Interventions: OTHER: 5-HT measurement|OTHER: cerebral MRI|OTHER: Video recording|OTHER: EEG|OTHER: growth curves|OTHER: ASQ questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Natalizumab De-escalation to Interferon-beta-1b in Patients With Relapsing-remitting Multiple Sclerosis
Status: TERMINATED
Conditions: Relapsing-remitting Multiple Sclerosis
Interventions: DRUG: Interferon beta-1b
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Comparison of Effectivity Therapy by HILT and TRT in Muscle Hypertonus
Status: ENROLLING_BY_INVITATION
Conditions: Muscle Tone Abnormalities|Muscle Spasm
Interventions: DEVICE: HILT laserotherapy|DEVICE: TRT therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study on Pembrolizumab in Recurrent, Platinum Resistant, CPS >1 Positive Ovarian, Fallopian Tube and Primary Peritoneal Cancer Patients
Status: RECRUITING
Conditions: Ovarian Cancer|Primary Peritoneal Carcinoma|Fallopian Tube Cancer
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of Various Sleep Assessment Tools in SICU
Status: COMPLETED
Conditions: Sleep|Sleep Disturbance|Sleep Deprivation|Polysomnography|Surveys and Questionnaires|Intensive Care Unit|Adult
Interventions: DIAGNOSTIC_TEST: Sleep measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Tranexamic Acid Injection With Different Drainage Clamping Time After Anterior Cruciate Ligament Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Reconstruction|Tranexamic Acid|Hemarthrosis, Knee
Interventions: DRUG: Tranexamic Acid Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of GERDOFF Efficacy in Combination With Proton Pump Inhibitor
Status: COMPLETED
Conditions: Gastro-oesophageal Reflux Disease
Interventions: DEVICE: GERDOFF® + Omeprazole|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mostafa Maged Maneuver in Comparison With Bimanual Uterine Compression to Control Post-partum Hemorrhage
Status: COMPLETED
Conditions: Post-partum Hemorrhage
Interventions: PROCEDURE: Mostafa Maged maneuver|PROCEDURE: Bimanual uterine compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Optimal Dose of Mannitol for Intraoperative Brain Relaxation During the Operation of Aneurysmal Subarachnoid Hemorrhage
Status: ACTIVE_NOT_RECRUITING
Conditions: Aneurysmal Subarachnoid Hemorrhage
Interventions: DRUG: Mannitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK1278863A in Healthy Subjects
Status: COMPLETED
Conditions: Anaemia
Interventions: DRUG: GSK1278863A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy in Combination With Brachytherapy for Clinically Localized, Intermediate Risk Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: RADIATION: external beam radiation therapy|RADIATION: brachytherapy|BEHAVIORAL: questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Anthelmintic Treatment on the Incidence of Diarrheal Disease in Vietnamese School Children
Status: WITHDRAWN
Conditions: Intestinal Helminthiasis|Diarrhea
Interventions: DRUG: Albendazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Administration of Prothrombin Complex Concentrate vs. Standard Transfusion During/After Heart Transplantation
Status: RECRUITING
Conditions: Heart Disease End Stage|Heart Failure，Congestive
Interventions: DRUG: Kcentra|DRUG: Frozen Plasma Product, Human
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Plaque Photoablation Using an Excimer Laser in Patients With Lower Extremity Vascular Disease
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: RA-308 Excimer Laser and DABRA Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketones in Heart Failure - Effects on Cardiac Efficiency
Status: COMPLETED
Conditions: Heart Failure, Systolic|Ketonemia
Interventions: BIOLOGICAL: Infusion of 3-OHB|BIOLOGICAL: Infusion of placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ETDRS PRP With IVR Versus Retinal Photocoagulation Targeted to Ischemic Retina With IVR for the Treatment of PDR
Status: COMPLETED
Conditions: Diabetic Retinopathy
Interventions: PROCEDURE: ISQ-RP|PROCEDURE: ETDRS-PRP group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Lubricant Versus Lidocaine Gel for Pain Control During Urodynamics
Status: COMPLETED
Conditions: Pelvic Floor Disorders
Interventions: DRUG: 2% lidocaine gel|DRUG: Water based lubricant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Mouth-rinse With Chlorhexidine for the Prevention of Ventilator-associated Infections in Intensive Care Unit
Status: UNKNOWN
Conditions: Infections Associated With Mechanical Ventilation|Pneumonia Associated With Mechanical Ventilation
Interventions: PROCEDURE: Mouth-rinse with 0.12% clorhexidine|PROCEDURE: Mouth-rinse with isotonic solution with 1.5% sodium bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Parsaclisib With or Without Polatuzumab Vedotin Plus the Standard Drug Therapy in Patients With Newly Diagnosed, High Risk Diffuse Large B-cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Ann Arbor Stage II Diffuse Large B-Cell Lymphoma|Ann Arbor Stage II Follicular Lymphoma|Ann Arbor Stage II Marginal Zone Lymphoma|Ann Arbor Stage III Diffuse Large B-Cell Lymphoma|Ann Arbor Stage III Follicular Lymphoma|Ann Arbor Stage III Marginal Zone Lymphoma|Ann Arbor Stage IV Diffuse Large B-Cell Lymphoma|Ann Arbor Stage IV Follicular Lymphoma|Ann Arbor Stage IV Marginal Zone Lymphoma|Diffuse Large B-Cell Lymphoma|High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements|High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements|High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements|Indolent Non-Hodgkin Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Doxorubicin Hydrochloride|DRUG: Parsaclisib|BIOLOGICAL: Pegfilgrastim|DRUG: Polatuzumab Vedotin|DRUG: Prednisone|BIOLOGICAL: Rituximab|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Jet Injection of 1% Buffered Lidocaine Versus Topical ELA-Max for Anesthesia Prior to Intravenous (IV) Catheterization in Children
Status: COMPLETED
Conditions: Pain
Interventions: PROCEDURE: J-tip jet injection of 1% buffered lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Phase I Trial of a Recombinant SARS-CoV-2 Vaccine (Sf9 Cell)
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Two doses of middle-dose recombinant SARS-CoV-2 vaccine (Sf9 Cell) at the schedule of day 0, 28|BIOLOGICAL: Two doses of high-dose recombinant SARS-CoV-2 vaccine (Sf9 Cell) at the schedule of day 0, 28|BIOLOGICAL: Three doses of high-dose recombinant SARS-CoV-2 vaccine (Sf9 Cell) at the schedule of day 0, 14, 28|BIOLOGICAL: Two doses of placebo at the schedule of day 0, 28（middle-dose group）|BIOLOGICAL: Two doses of placebo at the schedule of day 0, 28（high-dose group）|BIOLOGICAL: Three doses of placebo at the schedule of day 0, 14, 28（high-dose group）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Biological Therapy in Treating Patients With Advanced Cancer
Status: COMPLETED
Conditions: Breast Cancer|Gastric Cancer|Ovarian Cancer
Interventions: BIOLOGICAL: HER-2/neu intracellular domain protein|BIOLOGICAL: therapeutic autologous dendritic cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate Combined With Intravitreal Ranibizumab in the Treatment of Choroidal Neovascularization Secondary to Age-Related Macular Degeneration
Status: WITHDRAWN
Conditions: Choroidal Neovascularization
Interventions: DRUG: Imatinib Mesylate /Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Light Reduction on Retinopathy of Prematurity (Light-ROP)
Status: COMPLETED
Conditions: Retinopathy of Prematurity
Interventions: DEVICE: Goggles|PROCEDURE: Ambient Light Reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Adding Sufentanil to Epidural Ropivacaine on Perioperative Metabolic and Stress Responses in Combined General/Epidural Anaesthesia for Geriatric Radical Retropubic Prostatectomy
Status: COMPLETED
Conditions: Prostatic Cancer
Interventions: DRUG: epidural infusion of saline, ropivecaine, or ropivacaine and sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: Is Pleth Variability Index (PVI) a Surrogate for Pulse Pressure Variations (PPV) in Pediatric Spine Fusion (SF) Surgery?
Status: COMPLETED
Conditions: Scoliosis|Spinal Fusion
Interventions: DEVICE: Masimo multi-wavelength pulse co-oximeter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomised Controlled Clinical Trial of Cognitive Rehabilitation in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Cognitive Rehabilitation
Interventions: BEHAVIORAL: specific cognitive rehabilitation|BEHAVIORAL: non specific cognitive rehabilitation|OTHER: no intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Neurontin on Pain Management in the Acutely Burned Patient
Status: COMPLETED
Conditions: Pain|Burn Injury
Interventions: DRUG: Gabapentin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Combining FOLFOX or FOLFIRI With AG-013736 or Bevacizumab (Avastin) in Patients With Metastatic Colorectal Cancer After Failure Of One First Line Regimen
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: DRUG: Bevacizumab (avastin)|DRUG: FOLFIRI (Irinotecan, leucovorin, 5-fluorouracil [5FU])|DRUG: AG-013736 (axitinib)|DRUG: FOLFOX (oxaliplatin, leucovorin, 5-fluorouracil [5FU])|DRUG: AG-013736 (axitinib)|DRUG: FOLFIRI (irinotecan, leucovorin, 5-fluorouracil [5FU])|DRUG: Bevacizumab (avastin)|DRUG: FOLFOX (oxaliplatin, leucovorin, 5-fluorouracil [5FU])
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-market Surveillance Study of an Infant Formula Containing Moderately Hydrolyzed Protein and Low Lactose
Status: UNKNOWN
Conditions: Infant Nutrition Disorders|Gastrointestinal Dysfunction
Interventions: DIETARY_SUPPLEMENT: Drink the study formula (NAN Comfort producted by Nestle Deutschland AG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Flax, Poppy, Sesame & Salba on Postprandial Blood Glucose Response, Vascular, Appetite & Sensory Parameters
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DIETARY_SUPPLEMENT: Salba|DIETARY_SUPPLEMENT: Poppy|DIETARY_SUPPLEMENT: Flaxseed|DIETARY_SUPPLEMENT: Sesame|DIETARY_SUPPLEMENT: Wheat Bran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Silk Protein Microparticle-based Filler for Injection Augmentation
Status: COMPLETED
Conditions: Vocal Cord Paralysis Unilateral|Dysphonia|Dysphagia, Oropharyngeal
Interventions: PROCEDURE: Silk Microparticle Filler Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Closed-loop TIVA Propofol, Sufentanil and Ketamine Guided by BIS Monitor
Status: COMPLETED
Conditions: Acute Cholecystitis|Chronic Cholecystitis
Interventions: PROCEDURE: TIVA - Hypotension|PROCEDURE: TIVA - Hypertension|PROCEDURE: TIVA - Bradycardia|PROCEDURE: TIVA - Tachycardia|PROCEDURE: INH - Hypotension|PROCEDURE: INH - Hypertension|PROCEDURE: INH - Bradycardia|PROCEDURE: INH - Tachycardia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Apatinib and Etoposide in Patients With Platinum Resistant or Refractory Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Apatinib|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pediatric Exploratory Research Study of EGCG Use and Safety (PERSEUS)
Status: COMPLETED
Conditions: Down Syndrome|Fragile X Syndrome
Interventions: DIETARY_SUPPLEMENT: EGCG FontUp|OTHER: Placebo FontUp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Mitomycin-c/ Capecitabine ChemoRadiotherapy Combined With Nivolumab Monotherapy or Ipilumimab and Nivolumab, as Bladder Sparing Curative Treatment for Muscle Invasive Bladder Cancer: the CRIMI Study
Status: RECRUITING
Conditions: Urinary Bladder Cancer|Invasive Bladder Cancer
Interventions: COMBINATION_PRODUCT: nivolumab 480mg|COMBINATION_PRODUCT: nivolumab 3mg/kg, ipilimumab 1mg/kg|COMBINATION_PRODUCT: nivolumab 1mg/kg, ipilimumab 3mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NUTRI-HAB - Posttreatment Rehabilitation of Nutrition Impact Symptoms in Head and Neck Cancer Survivors
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: OTHER: NUTRI-HAB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Amniotic Membrane as an Adjunct Treatment for Hallux Rigidus
Status: COMPLETED
Conditions: Hallux Rigidus
Interventions: PROCEDURE: Dorsal Cheilectomy without Amniotic Membrane Tissue Implantation|PROCEDURE: Dorsal Cheilectomy with Amniotic Membrane Tissue Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Pregabalin, Duloxetine & Amitriptyline on Pain & Sleep
Status: COMPLETED
Conditions: Diabetes Mellitus|Peripheral Neuropathies
Interventions: DRUG: Pregabalin|DRUG: Duloxetine|DRUG: Amitriptyline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Reyataz in HIV-infected Patients With Lipodystrophy Syndrome
Status: COMPLETED
Conditions: HIV-Associated Lipodystrophy Syndrome
Interventions: DRUG: Atazanavir (ATV) + ritonavir (RTV), continuation of backbone 2 nucleoside reverse transcriptase inhibitor (NRTIs)|DRUG: continuation of current HAART (boosted protease inhibitor [PI] combination + 2 NRTIs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep and Pain Interventions in Women With Fibromyalgia
Status: RECRUITING
Conditions: Fibromyalgia|Insomnia|Chronic Widespread Pain
Interventions: BEHAVIORAL: Cognitive Behavioral Treatment-Insomnia|BEHAVIORAL: Sleep Hygiene Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Cetuximab in Combination With Encorafenib Plus Binimetinib as Induction Treatment in BRAF V600E Mutated MSS Initially Resectable or Potentially Resectable Advanced Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: EBC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Palonosetron for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Participants Who Have Experienced CINV(Chemotherapy-Induced Nausea and Vomiting) During the Previous Cycle of Low Emetogenic Chemotherapy (LEC)
Status: COMPLETED
Conditions: Patients With Confirmed Malignant Disease to Receive Low Emetogenic Chemotherapy (LEC) or Who Experienced at Least Nausea and Vomiting During Last Cycle of LEC
Interventions: DRUG: palonesetron
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Randomized, Open-Label, Crossover, Multicenter, Single Dose Comparator Study Evaluating Onset Of Penile Rigidity In Men With Erectile Dysfunction Who Are Treated With Sildenafil And Tadalafil
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: tadalafil|DRUG: sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of BIA 6-512 at Steady-state on the Levodopa Pharmacokinetics
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Placebo|DRUG: BIA 6-512|DRUG: Madopar® 250|DRUG: Comtan®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fiber Metabolism in Chronic Obstructive Pulmonary Disease
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease|Aging
Interventions: DIETARY_SUPPLEMENT: Fiber Inulin|DIETARY_SUPPLEMENT: Placebo Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study To Assess ZD6474 (ZACTIMA™) Monotherapy In Locally Advanced or Metastatic Hereditary Medullary Thyroid Cancer
Status: COMPLETED
Conditions: Thyroid Cancer
Interventions: DRUG: ZD6474 (vandetanib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual-Reality and Cold-Vibration Device on Procedure-Related Fear, Anxiety and Pain During Pediatric IV Line Placement
Status: COMPLETED
Conditions: Pain|Fear|Anxiety|Child, Only
Interventions: DEVICE: virtual reality|DEVICE: Cold vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetics, Safety, Tolerability of Dolutegravir/Rilpivirine in Pediatrics
Status: RECRUITING
Conditions: HIV Infections
Interventions: DRUG: Dolutegravir/Rilpivirine FDC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Spinal Anesthesia Versus Epidural Anesthesia in Geriatric
Status: COMPLETED
Conditions: Epidural Catheter
Interventions: OTHER: Continuous spinal anesthesia|OTHER: Continuous epidural anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Linking Cognitive Functioning to Multimodal Imaging in Multiple Sclerosis (MS)
Status: TERMINATED
Conditions: Multiple Sclerosis|Cognition Disorders
Interventions: DIAGNOSTIC_TEST: Siemens Biograph mMR (molecular MR)|DIAGNOSTIC_TEST: fMRI|DIAGNOSTIC_TEST: Diffusion Spectrum Imaging (DSI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Efficacy of LGIT and MAD Among Children With Drug Resistant Epilepsy
Status: UNKNOWN
Conditions: Drug Resistant Epilepsy|Ketogenic Dieting
Interventions: OTHER: Low glycemic Index Therapy (LGIT)|OTHER: Modified Atkins Diet (MAD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Synergistic Effect of Ibuprofen and Hydromorphone for Postoperative Pain
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Ibuprofen|DRUG: Hydromorphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Understanding Cerebral Blood Flow Dynamics for Alzheimer's Disease Prevention Through Exercise
Status: NOT_YET_RECRUITING
Conditions: Healthy Aging|Cognitive Function 1, Social|Cerebrovascular Circulation|Blood Flow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of IMC-RON8 in Advanced Solid Tumors
Status: COMPLETED
Conditions: Cancer
Interventions: BIOLOGICAL: IMC-RON8|BIOLOGICAL: IMC-RON8|BIOLOGICAL: IMC-RON8|BIOLOGICAL: IMC-RON8|BIOLOGICAL: IMC-RON8|BIOLOGICAL: IMC-RON8|BIOLOGICAL: IMC-RON8|BIOLOGICAL: IMC-RON8
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-operative Treatment Versus Volar Locking Plate in Treatment of Distal Radius Fracture in Patients Over 65 Years
Status: COMPLETED
Conditions: Distal Radius Fracture
Interventions: PROCEDURE: non-operative treatment|PROCEDURE: operative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II, Open Label Study to Evaluate the Antiviral Potential of Combination Zidovudine and 2' 3'-Dideoxyinosine (Didanosine) in Patients With Asymptomatic HIV Disease
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zidovudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Mechanistic Study of GSK3228836 With Fine Needle Aspiration (FNA) in Participants With Chronic Hepatitis B
Status: COMPLETED
Conditions: Hepatitis B
Interventions: DRUG: GSK3228836|DRUG: Nucleos(t)ide therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Axatilimab With or Without Azacitidine for the Treatment of Patients With Advanced Phase Myeloproliferative Neoplasms, Myeloproliferative Neoplasm/Myelodysplastic Syndrome Overlap or High Risk Chronic Myelomonocytic Leukemia
Status: NOT_YET_RECRUITING
Conditions: Atypical Chronic Myeloid Leukemia|Chronic Myelomonocytic Leukemia|Myelodysplastic/Myeloproliferative Neoplasm|Recurrent Myelodysplastic/Myeloproliferative Neoplasm|Recurrent Myeloproliferative Neoplasm|Refractory Chronic Myelomonocytic Leukemia|Refractory Myelodysplastic/Myeloproliferative Neoplasm|Refractory Myeloproliferative Neoplasm
Interventions: BIOLOGICAL: Axatilimab|DRUG: Azacitidine|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration and Biopsy|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iberoamerican Protocol With Thalidomide in Patients With Symptomatic Newly Diagnosed Multiple Myeloma Over 65 Years
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Thalidomide, Cyclophosphamide, Dexamethasone|DRUG: Thalidomide, Dexamethasone|DRUG: Thalidomide, Melphalan, Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zolmitriptane as Prophylaxis for Chilhood Migraine
Status: RECRUITING
Conditions: Migraine
Interventions: DRUG: zolmitriptanee|DRUG: topiramate|DRUG: Valproate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treating Parents With ADHD and Their Young Children Via Telehealth: A Hybrid Type I Effectiveness-Implementation Trial
Status: RECRUITING
Conditions: ADHD|Parenting
Interventions: BEHAVIORAL: Behavioral Parent Training|DRUG: Extended release mixed amphetamine salts (MAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Immunogenicity of MenABCWY Administered on Different Dosing Schedules in Healthy Adolescents
Status: ACTIVE_NOT_RECRUITING
Conditions: Meningitis, Meningococcal
Interventions: COMBINATION_PRODUCT: MenABCWY vaccine|COMBINATION_PRODUCT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cabozantinib in Combination With Avelumab in Patients Refractory to Standard Chemotherapy With Advanced Neuroendocrine Neoplasias G3 (NEN G3)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer
Interventions: DRUG: combination of Avelumab and Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Different Doses of BI 3011441 in Japanese People With Different Types of Advanced Cancer (NRAS/KRAS Mutation Positive)
Status: COMPLETED
Conditions: Solid Tumors, KRAS Mutation
Interventions: DRUG: BI 3011441
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM)
Status: COMPLETED
Conditions: Arrhythmia|Atrial Fibrillation|Cardiovascular Diseases|Heart Diseases
Interventions: DRUG: amiodarone|DRUG: sotalol|DRUG: propafenone|DRUG: flecainide|DRUG: quinidine|DRUG: moricizine|DRUG: disopyramide|DRUG: procainamide|DRUG: adrenergic beta antagonists|DRUG: verapamil|DRUG: diltiazem|DRUG: digoxin|PROCEDURE: catheter ablation|DEVICE: pacemaker, artificial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Omega-3 Fatty Acids in Bariatric Gastric Bypass Surgery: Effect on Liver Volume, Immune Response and Erythrocyte Function
Status: COMPLETED
Conditions: Morbid Obesity
Interventions: DRUG: Omega-3 fatty acid capsules|BEHAVIORAL: Low calorie diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RIvoraxaban in Mitral Stenosis
Status: TERMINATED
Conditions: Mitral Stenosis|Rheumatic Heart Disease|Atrial Fibrillation|Anticoagulant Adverse Reaction
Interventions: DRUG: Rivaroxaban|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Conditions of Realization of the Echocardiography in Newborns
Status: COMPLETED
Conditions: Premature Newborn
Interventions: PROCEDURE: echocardiography with postural support|PROCEDURE: echocardiography with standard condition (usual)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment Efficacy of Mindfulness-based Cognitive Therapy for Distress in Advanced Cancer Patients
Status: ENROLLING_BY_INVITATION
Conditions: Cancer Pain|Cancer|Distress, Emotional|Therapy-Associated Cancer|Psychiatric or Mood Diseases or Conditions|Psychological Distress
Interventions: BEHAVIORAL: Mindfulness-Based Cognitive-behavioral Therapy for Distress
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-oxygenation Methods in Bariatric Patients
Status: COMPLETED
Conditions: Obesity|Anesthesia|Bariatric Surgery Candidate
Interventions: DEVICE: Optiflow and THRIVE technique|DEVICE: Standard anaesthetic face mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iron Dosing Pilot Study Using Model Predictive Control
Status: COMPLETED
Conditions: Renal Insufficiency, Chronic|Anemia, Iron Deficiency|Anemia of Chronic Kidney Disease
Interventions: DEVICE: Model predictive control|DEVICE: Model Predictive Control of Iron Dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: GSK189075, GW869682 Or Placebo In Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Non-Insulin-Dependent Diabetes Mellitus
Interventions: DRUG: GSK189075 oral tablets|DRUG: GW869682 oral tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: T3011 in Combination With Cobimetinib in Patients With Advanced Melanoma
Status: SUSPENDED
Conditions: Melanoma|Malignant Melanoma
Interventions: COMBINATION_PRODUCT: T3011 + Cobimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gefitinib in Treating Patients With Cervical Cancer
Status: COMPLETED
Conditions: Cervical Cancer|Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: gefitinib|OTHER: immunohistochemistry staining method|OTHER: surface-enhanced laser desorption/ionization-time of flight mass spectrometry|PROCEDURE: biopsy|PROCEDURE: sentinel lymph node biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Tibial Tubercle Distalisation and Accelerated Rehabilitation
Status: NOT_YET_RECRUITING
Conditions: Patella Alta|Tibial Tubercle Distalisation Osteotomy|Rehabilitation
Interventions: PROCEDURE: Accelerated rehabilitation protocol|PROCEDURE: Conservative rehabilitation protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hand Dynamometer and Clinical Tests to Evaluate Neuromuscular Recovery in Atracurium vs Rocuronium
Status: RECRUITING
Conditions: Neuromuscular Block Prolonged
Interventions: DEVICE: Randomize clinical trial using hand dynamometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Aerobic Physical Training and Heart Rate Variability in Hypertersion
Status: COMPLETED
Conditions: Autonomic Nervous System Diseases
Interventions: BEHAVIORAL: Physical training program|BEHAVIORAL: Physical training program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Safety and Tolerability Trial With Nab-Paclitaxel Plus Carboplatin Followed by Nab-Paclitaxel for First Line Treatment of NSCLC Subjects With ECOG PS 2
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: nab-Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: Sotorasib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Assess the Efficacy of a Plant-based Energy Shot on Focus and ADHD-like Symptoms
Status: COMPLETED
Conditions: ADHD|Attention Difficulties|Mood|Anxiety|Caffeine
Interventions: OTHER: Proper Wild energy shot
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Use Modular Medical Equipment Vehicle in Mobilization of Patient With Chest Tube
Status: COMPLETED
Conditions: Mobility Limitation|Sleep Quality|Pain|Comfort|Time of the Removal Chest Tube
Interventions: OTHER: mobilization with moduler medical equipment carring vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Validation of an Environmental Exposure Chamber for Inhalation Studies With House Dust Mite Allergen in Patients With Allergic Rhinitis
Status: COMPLETED
Conditions: Allergy to House Dust Mite
Interventions: PROCEDURE: Exposure to house dust mite
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Post Covid-19 Dysautonomia Rehabilitation Randomized Controlled Trial
Status: RECRUITING
Conditions: Post-Acute COVID-19 Syndrome|Dysautonomia
Interventions: PROCEDURE: Rehabilitation|PROCEDURE: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Wound Closure (Allgower) Versus Secondary Open Wound Healing After Removal of the External Fixator
Status: COMPLETED
Conditions: Infection Rates Between Primary Wound-closure (Allgower) and Secondary Wound Healing After Removal of an External Fixator
Interventions: PROCEDURE: Primary wound closure in Allgower Technique vs. secondary open wound healing of pin-sides after removal of the fixated-externe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke With Mild Symptoms
Status: COMPLETED
Conditions: Ischemic Stroke|Acute Stroke
Interventions: PROCEDURE: Mechanical Thrombectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lumbar Manipulation for Hip and Muscle Strength
Status: COMPLETED
Conditions: Patellofemoral Pain Syndrome|Anterior Knee Pain Syndrome
Interventions: PROCEDURE: Lumbar Spine Manipulation|PROCEDURE: Lumbar Spine Manipulation Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CorPath® GRX Neuro Study
Status: COMPLETED
Conditions: Intracranial Aneurysm|Subarachnoid Hemorrhage|Headache
Interventions: DEVICE: Robotic Endovascular Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proactive Management of Endoperitoneal Spread in Colonic Cancer
Status: NOT_YET_RECRUITING
Conditions: Colon Cancer|Intraperitoneal Rectal Cancer
Interventions: PROCEDURE: Standard surgical treatment|PROCEDURE: Proactive management|DRUG: Standard adjuvant systemic chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Safety and Effectiveness Study of a New Contact Lens Cleaning and Disinfecting Solution
Status: COMPLETED
Conditions: Contact Lens Wear
Interventions: DEVICE: Complete MPS|DEVICE: NNR06
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study With Dendritic Cell Immunotherapy in Resected Hepatic Metastasis of Colorectal Carcinoma
Status: UNKNOWN
Conditions: Colorectal Carcinoma|Hepatic Metastasis
Interventions: DRUG: Dendritic cells vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Hippocampal Hyperactivity and Improving Cognition in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Levetiracetam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Telehealth & Remote Measurement Technologies to Improve Medication Adherence in Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: Computer Controlled Telephone Counseling|OTHER: Physician information and management recommendations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase IIIB-IV Long-Term Follow-up Study for Patients Who Participated in CAMMS03409
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: alemtuzumab GZ402673
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irinotecan and Cetuximab for Colorectal Cancer as Second Line Therapy
Status: COMPLETED
Conditions: Colon Cancer|Rectum Cancer
Interventions: DRUG: Cetuximab|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Colony Stimulating Factor on Implantation and Pregnancy Rates Following IVF (in Vitro Fertilization)
Status: COMPLETED
Conditions: Infertility, Female
Interventions: DRUG: G-CSF|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of Alefacept in Psoriasis Patients for Whom Conventional Treatment is Ineffective or Inappropriate
Status: COMPLETED
Conditions: Chronic Plaque Psoriasis
Interventions: DRUG: alefacept|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Feasibility of Reduced Port Robotic Distal Gastrectomy Using Single-site for Surgical Treatment of Early Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: PROCEDURE: Reduced port robotic distal gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Complete Endoscopic Mucosal Resection (EMR) of Colorectal Neoplasia
Status: COMPLETED
Conditions: Neoplasms|Gastric Cancer
Interventions: PROCEDURE: Standard of Care Procedure as described in ARM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sciatic Nerve Slider Technique in Different Positions in Low Back Pain Patients
Status: COMPLETED
Conditions: Low Back Pain|Sciatica
Interventions: OTHER: sciatic nerve slider technique in slump lying position|OTHER: sciatic nerve slider technique in supine position|OTHER: Conventional physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The RolE oF Androgen Excess in MUscle Energy MetaboLism in Women With PolyCystic Ovary Syndrome (REFUEL PCOS) Study 2
Status: NOT_YET_RECRUITING
Conditions: Polycystic Ovary Syndrome|Androgen Excess|Metabolic Disease
Interventions: DRUG: Bicalutamide 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: BEOVU Versus Eylea in the Treatment of Age-related Macular Neovascular Degeneration
Status: UNKNOWN
Conditions: Macula Lutea Degeneration
Interventions: DRUG: intravitreal injection|DRUG: intravitreal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Long-term Follow-up Durability (Efficacy) Study of EN3835 for the Treatment of AC of the Shoulder (Frozen Shoulder)
Status: TERMINATED
Conditions: Adhesive Capsulitis|Frozen Shoulder
Interventions: DRUG: Previously treated with EN3835 up to 1.74 mg or Placebo in EN3835-210 or the pivotal phase 3 studies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cancer Rehab Program for Allogenic Bone and Marrow Transplant Patients - CaRE-4-alloBMT
Status: COMPLETED
Conditions: Allogeneic Disease|Hematologic Cancer|Cancer Rehabilitation
Interventions: BEHAVIORAL: CaRE-4-alloBMT plus usual care group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Indirect Laryngoscopy for Nasal Intubation
Status: COMPLETED
Conditions: Intubation, Intratracheal
Interventions: DEVICE: Airtraq laryngoscope|DEVICE: Glidescope laryngoscope|DEVICE: Macintosh laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Safety and Efficacy of a Vascular Prosthesis for Hemodialysis Access in Patients With End-Stage Renal Disease
Status: COMPLETED
Conditions: End-stage Renal Disease|Kidney Failure, Chronic
Interventions: BIOLOGICAL: HAVG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Impact of Mesh Pore Size on Chronic Pain After Lichtenstein Hernioplasty
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: DEVICE: Optilene LP mesh|DEVICE: Ultrapro mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Transdiagnostic Cognitive Behavioral Treatment for Anxiety
Status: COMPLETED
Conditions: Anxiety Disorders
Interventions: BEHAVIORAL: Intensive Cognitive Behavior Therapy (iCBT)|BEHAVIORAL: Standard Cognitive Behavior Therapy (sCBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sinquanon for Prevention of Antibiotic-associated Diarrhea in Adults
Status: COMPLETED
Conditions: Antibiotic-associated Diarrhea
Interventions: DIETARY_SUPPLEMENT: Sinquanon|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Antenatal Chlamydia Infection
Status: COMPLETED
Conditions: Chlamydia Trachomatis Infection in Pregnancy
Interventions: DRUG: Amoxicillin|DRUG: Erythromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Cholecystectomy With Retro-infundibular Approach
Status: COMPLETED
Conditions: Gallstones
Interventions: PROCEDURE: standard laparoscopic cholecystectomy|PROCEDURE: RI approach
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3-point vs 6-point GNRFA for Chronic KOA
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis, Knee|Chronic Pain
Interventions: PROCEDURE: Radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Diagnostic Assessment and Intervention Study of Amphetamine Type Stimulus
Status: COMPLETED
Conditions: Amphetamine Addiction
Interventions: BEHAVIORAL: psychological rehabilitation training|BEHAVIORAL: physical and neurological rehabilitation training|RADIATION: rTMS 10HZ high frequency stimulation|RADIATION: fake rTMS 10HZ high frequency stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Four Arm Food Effect Study of Fenofibric Acid Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Fenofibric Acid 105 mg Tablet|DRUG: Fenofibric Acid 105 mg Tablet|DRUG: Fenofibric Acid 105 mg Tablet|DRUG: Fenofibric Acid 105 mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE