pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Microvesicles and Exosomes Therapy on β-cell Mass in Type I Diabetes Mellitus (T1DM)
Status: UNKNOWN
Conditions: Diabetes Mellitus Type 1
Interventions: BIOLOGICAL: MSC exosomes.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chidamide Combined With Clad/Gem/Bu With AutoSCT in High Risk Hodgkin & Non-Hodgkin Lymphoma
Status: UNKNOWN
Conditions: Hodgkin Lymphoma|Non-hodgkin Lymphoma
Interventions: DRUG: Chidamide|DRUG: Cladribine|DRUG: gemcitabine|DRUG: Busulfan|PROCEDURE: Autologous hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flavopiridol in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Chronic Myelogenous Leukemia
Status: TERMINATED
Conditions: Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Blastic Phase Chronic Myelogenous Leukemia|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Relapsing Chronic Myelogenous Leukemia
Interventions: DRUG: alvocidib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anlotinib Plus Everolimus as First-line Treatment for Advanced Non Clear Cell Renal Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Anlotinib hydrochloride|DRUG: everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Vivomixx on Behaviour and Gut Function in Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DIETARY_SUPPLEMENT: Vivomixx|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lung and Bone Marrow Transplantation for Lung and Bone Marrow Failure
Status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis|Emphysema or COPD
Interventions: BIOLOGICAL: CD3/CD19 negative hematopoietic stem cells|DRUG: Rituximab|DRUG: Alemtuzumab|DRUG: Fludarabine|DRUG: Thiotepa|DRUG: G-CSF|DRUG: Hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Physical Activity on the Brain in Impaired Glucose Tolerance (IGT)
Status: COMPLETED
Conditions: Impaired Glucose Tolerance
Interventions: BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study With Immunotherapy Combinations in Participants With Metastatic Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Advanced Non-Small Cell Lung Cancer
Interventions: DRUG: Domvanalimab|DRUG: Quemliclustat|DRUG: Zimberelimab|DRUG: Docetaxel|DRUG: Platinum-Based Doublet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EMBOSS A Person-centred Integrated-care for Chronic Diseases in Patients of Low Socio Economic Status
Status: RECRUITING
Conditions: Chronic Condition|Chronic Conditions, Multiple
Interventions: BEHAVIORAL: Person-centred integrated care intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Long-term Safety Extension Study of Tocilizumab in Brazilian Participants With Rheumatoid Arthritis (RA) Who Completed the Studies ML21530 and MA21488
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: DMARDs|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Investigate the Efficacy and the Safety of DA-9501 in Sedation During the Surgery or Medical Procedure Without Intubation
Status: COMPLETED
Conditions: Sedation
Interventions: DRUG: DA-9501|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TKIs vs. Pertuzumab in HER2+ Breast Cancer Patients With Active Brain Metastases (HER2BRAIN)
Status: NOT_YET_RECRUITING
Conditions: HER2-positive Breast Cancer|Brain Metastases
Interventions: DRUG: Trastuzumab|DRUG: Taxanes|DRUG: Pertuzumab|DRUG: Tyrosine kinase inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine Whether EGFR Status by FISH Can Predict Results in Non Small Cell Lung Cancer (NSCLC) Patients Treated With Cetuximab, Carboplatin and Paclitaxel
Status: WITHDRAWN
Conditions: Lung Neoplasms|Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Cetuximab|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Bupropion on Smoking Behavior in Smokers With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Tobacco Use Disorder
Interventions: DRUG: 300 mg/day bupropion-sr|DRUG: 0 mg/day bupropion-sr
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: N-Butyl-2-Cyanoacrylate Injection Versus Band Ligation for Gastric Variceal Hemorrhage
Status: COMPLETED
Conditions: Gastric Variceal Hemorrhage
Interventions: PROCEDURE: cyanoacrylate injection to treat gastric variceal hemorrhage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SPIRIT 2: Efficacy and Safety Study of Relugolix in Women With Endometriosis-Associated Pain
Status: COMPLETED
Conditions: Endometriosis Related Pain
Interventions: DRUG: Relugolix|DRUG: Estradiol/norethindrone acetate|DRUG: Estradiol/norethindrone acetate placebo|DRUG: Relugolix placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RESIST! Blood-flow Restriction Resistance Training for Improving Insulin Sensitivity in Type 2 Diabetes
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: OTHER: Blood-flow restriction resistance training|OTHER: Classical resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Switching From Racemic Methadone to R-methadone on QTc Intervals
Status: ACTIVE_NOT_RECRUITING
Conditions: Adverse Drug Effect|Drug Effect|Heart Arrhythmia
Interventions: DRUG: Same individuals treated with racemic methadone and switched to levomethadone (R-methadone)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Noninvasive Hemoglobin Disposable Sensors
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Rainbow adhesive adult/pediatric sensor|DEVICE: Rainbow adhesive adult/neonatal sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Capecitabine, Oxaliplatin, and Radiation Therapy in Treating Patients Who Are Undergoing Surgery for Stage I Rectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: capecitabine|DRUG: oxaliplatin|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Telephone-Assisted Smoking Cessation Program in Patients Diagnosed With Non-Muscle Invasive Bladder Cancer
Status: NOT_YET_RECRUITING
Conditions: Non-Muscle Invasive Bladder Cancer|Self Efficacy|Smoking Behaviors|Tumor Recurrence|Progression, Disease
Interventions: BEHAVIORAL: Behavioral: Motivational Interviewing with WhatsApp video call
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preoperative Ondansetron Lozenge for Prevention of Postoperative Nausea and Vomiting in Caesarean Section
Status: RECRUITING
Conditions: Ondansetron Lozenge|Postoperative Nausea and Vomiting|Caesarean Section
Interventions: DRUG: Ondansetron lozenge (Ondalenz ©)|DRUG: Ondansetron IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: sPERMIdine supplemenTation on Metabolic, Neuronal and Cardiovascular Response to Exercise TRAINING
Status: UNKNOWN
Conditions: Heart Failure, Diastolic
Interventions: DIETARY_SUPPLEMENT: spermidineLife|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Apatinib Combined With Capecitabine Second-line Treatment of Advanced Gastric Cancer: a Single-arm Exploratory Clinical Pilot Trial
Status: UNKNOWN
Conditions: Progression-free Survival;Progression-free Survival;Disease Control Rate; Safety
Interventions: DRUG: Apatinib/Capecitatine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pancreatic Head and Peri-ampullary Cancer Laparoscopic vs Open Surgical Treatment Trial (PLOT)
Status: COMPLETED
Conditions: Adenocarcinoma of Head of Pancreas|Cholangio Carcinoma|Duodenal Adenocarcinoma|Carcinoma of Ampulla of Vater
Interventions: PROCEDURE: Open surgery|PROCEDURE: Laparoscopic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity
Status: RECRUITING
Conditions: Obesity|Healthy|Vasoconstriction|Vasodilation
Interventions: OTHER: Hypoxia Exposure|DRUG: Phenylephrine|DRUG: Dexmedetomidine|DRUG: Phentolamine|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Dapagliflozin on Myocardial and Renal Function Following Aortic Valve Stenosis Intervention
Status: UNKNOWN
Conditions: Aortic Stenosis|Left Ventricle Hypertrophied
Interventions: DRUG: SGLT2 inhibitor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance and Safety Comparison of Stay Safe Link® With Stay Safe® in Patient on CAPD (CAPD-3)
Status: COMPLETED
Conditions: Continuous Ambulatory Peritoneal Dialysis
Interventions: DEVICE: Stay Safe Link (SSL)|DEVICE: Stay Safe (STS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study With Amitriptylin to Evaluate the Efficacy of Melatonin in Treatment of Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Amitriptyline|DRUG: Melatonin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Feedback on Physical Activity and Health-related Outcomes During Pulmonary Rehabilitation in COPD
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: BEHAVIORAL: Pulmonary rehabilitation (PR) plus PA-focused intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness and Cost-effectiveness of a VCoP to Empowerment of Patients With Ischaemic Heart Disease in PHC: Cluster-RCT
Status: COMPLETED
Conditions: Ischemic Heart Disease Chronic
Interventions: BEHAVIORAL: Virtual Communities of practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Internet Based Cognitive Behavioral Therapy in Pediatric Chronic Pancreatitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Pancreatitis|Acute Recurrent Pancreatitis
Interventions: BEHAVIORAL: Web-based CBT|BEHAVIORAL: Pain Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effectiveness of a Biopsychosocial-Based Exercise Model in Rheumatic Diseases: A Mixed Methods Research With Patients' Perspectives
Status: COMPLETED
Conditions: Rheumatic Diseases
Interventions: OTHER: Bilişsel Egzersiz Terapi Yaklaşımı (BETY, Cognitive Exercise Therapy Approach)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Plasmajet in Achieving Complete Cytoreduction of Advanced EOC- Initial Feasibility Study
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer
Interventions: DEVICE: Surgery for EOC with trial (PJ) device (PlasmaJet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation of Bivatuzumab Mertansine in Female Patients With CD44v6 Positive Recurrent or Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Neoplasms
Interventions: DRUG: bivatuzumab mertansine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Subcutaneous Implantable Cardiac Defibrillators (ICDs) Following Extraction of Conventional ICDs
Status: UNKNOWN
Conditions: Use of Subcutaneous ICDs Following Infection
Interventions: DEVICE: Cameron Health S-ICD SQ-RX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BPI-1178 in Patients With Advanced Solid Tumor and HR+/HER2- Breast Cancer
Status: RECRUITING
Conditions: Advanced Solid Tumor|HR+/HER2- Breast Cancer
Interventions: DRUG: BPI-1178|DRUG: Fulvestrant|DRUG: Letrozole|DRUG: BPI-1178
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A MolEcularly Guided Anti-Cancer Drug Off-Label Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: Atezolizumab|DRUG: Everolimus|DRUG: Cobimetinib|DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Pembrolizumab With Methotrexate in Elderly, Frail or Cisplatin-ineligible Patients With Head and Neck Cancers
Status: TERMINATED
Conditions: Cancer of Head and Neck
Interventions: DRUG: Pembrolizumab Injection|DRUG: Methotrexate Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Vildagliptin in Combination With Insulin in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Artemisinin Combination Therapies for the Treatment of Uncomplicated P. Falciparum in Pregnancy in Brazil
Status: TERMINATED
Conditions: Malaria
Interventions: DRUG: Artemether-Lumefantrine|DRUG: Mefloquine- Artesunate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin Type A for Cold Intolerance Secondary to Digital Amputations and Replantations: A Pilot Study
Status: UNKNOWN
Conditions: Cold Intolerance
Interventions: DRUG: Botulinum toxin type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colorectal Cancer Screening Using Stool DNA-based SDC2 Methylation Test
Status: COMPLETED
Conditions: Colorectal Cancer|Colon Polyp|Healthy
Interventions: DIAGNOSTIC_TEST: Earlytect Colon Cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Efficacy, Safety and Dose Finding Trial of Topical Jaungo Application in Atopic Dermatitis Patients
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: Jaungo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Dietary Supplement Containing L-Arabinose and Trivalent Patented Food-source of Chromium on Blood Glucose and Insulin
Status: COMPLETED
Conditions: Pre-diabetes
Interventions: DIETARY_SUPPLEMENT: L-Arabinose and Chromium|DIETARY_SUPPLEMENT: Sucrose without dietary Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Single Center Pilot Study of Corticosteroid Discontinuation in Liver Transplant Recipients
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: DRUG: tacrolimus|DRUG: mycophenolate mofetil|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tube Feeding in Children Having a Bone Marrow Transplant
Status: COMPLETED
Conditions: Bone Marrow Disease|Stem Cell Transplant Complications|Enteral Feeding Intolerance|Gastrostomy|Gastrostomy Complications|Experiences, Life
Interventions: DEVICE: Enteral feeding tubes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Protocol for a Feasibility Study of a Novel ACT-based eHealth Psychoeducational Intervention for Students With Mental Distress
Status: COMPLETED
Conditions: A Bite of ACT' (BOA) Acceptance and Commitment Therapy Online Psychoeducation Course|A Wait-list Control
Interventions: OTHER: 'A Bite of ACT' (BOA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study on Quality of Life Criteria of a Digital Application on Any Cellphone (OnKO-Tips&Tricks) for Adolescents and Young Adults Diagnosed With Cancer
Status: RECRUITING
Conditions: Cancer
Interventions: OTHER: OnKO-Tips&Tricks digital phone application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Paliperidone and Lithium in the Treatment of Suicidality - Treatment Indication and Epigenetic Regulation
Status: COMPLETED
Conditions: Major Depressive Disorder|Suicidal Ideation
Interventions: DRUG: paliperidone|DRUG: lithium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Pilates Exercises Training Volume on Metabolic Outcomes in Dyslipidemic Women.
Status: COMPLETED
Conditions: Dyslipidemias
Interventions: OTHER: High Volume Group|OTHER: Low Volume Group|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of SGM-1019 in Patients With Nonalcoholic Steatohepatitis (NASH)
Status: TERMINATED
Conditions: Nonalcoholic Steatohepatitis
Interventions: DRUG: SGM-1019|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Versus Intravenous Hydration to Prevent Contrast Induced Nephropathy
Status: WITHDRAWN
Conditions: Contrast Induced Nephropathy
Interventions: OTHER: Oral hydration|DRUG: Oral sodium bicarbonate|OTHER: Intravenous Hydration|DRUG: Intravenous sodium bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mapping Approaches to Prepare for Implementation Transfer (MAP-IT)
Status: UNKNOWN
Conditions: Mapping Approaches to Prepare for Implementation Transfer|Treatment Readiness and Induction Program
Interventions: BEHAVIORAL: Mapping Enhanced Counseling (MEC)|OTHER: Mapping Approaches to Prepare for Implementation Transfer (MAP-IT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis
Status: RECRUITING
Conditions: Platelets-rich Plasma|Osteoarthritis Knees Both|Meniscus Disorder|Cartilage Injury
Interventions: DRUG: Sodium hyaluronate injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Cardiac Rehabilitation on High Mobility Group Box-1 Levels After Acute Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: OTHER: Exercise-based Cardiac Rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Two Local Anesthetics on Quality of Life After Endodontic Treatment
Status: SUSPENDED
Conditions: Pain, Postoperative|Quality of Life
Interventions: DRUG: Bupivacaine Local Anesthetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Relationship Between Plasma Concentration of Hydroxyprogesterone Caproate (17-OHPC) and Preterm Birth
Status: TERMINATED
Conditions: Preterm Birth
Interventions: DRUG: 17-Hydroxyprogesterone caproate 250mg or 500 mg.|DRUG: Safety study of 500 mg dose.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy Study of the Combination Daclatasvir (60 mg), Sofosbuvir (400 mg) and Ribavirin (Weight-based Dosing) for 12 or 16 Weeks in Subjects With Genotype 3 Chronic HCV Infection With or Without Prior Treatment Experience and Advanced Fibrosis or Compensated Cirrhosis
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Daclatasvir|DRUG: Sofosbuvir|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Haploidentical Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major
Status: UNKNOWN
Conditions: Thalassemia Major
Interventions: DRUG: Busulfan|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Mycophenolate mofetil|DRUG: Tacrolimus|DRUG: Methotrexate|DRUG: Thymoglobulin|DRUG: Basiliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Giant Cell Arteritis and Anakinra Trial
Status: UNKNOWN
Conditions: Giant Cell Arteritis
Interventions: DRUG: PLACEBO|DRUG: ANAKINRA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Treating Sleep Disorder Breathing in Patients With Resistant Hypertension
Status: WITHDRAWN
Conditions: Sleep Apnea|Hypertension
Interventions: DEVICE: Autotitrating Positive Airway Pressure (APAP)|DEVICE: Traditional Split Titration Polysomnogram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Cisatracurium Versus Atracurium on Intraocular Pressure in Patients Underwent General Anesthesia
Status: COMPLETED
Conditions: Intraocular Pressure
Interventions: DRUG: atracurium|DRUG: cisatracurium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Voice Therapy With a Semi-occluded Vocal Tract
Status: COMPLETED
Conditions: Voice Disorders
Interventions: BEHAVIORAL: Straw phonation in air|BEHAVIORAL: straw phonation in water|BEHAVIORAL: /u/ phonation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Probiotic Treatment as a Supportive Therapy in Eradication of H. Pylori
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DIETARY_SUPPLEMENT: Normia|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the QBX Peripheral Balloon Expandable Stent System in Peripheral Artery Disease (PAD)
Status: NOT_YET_RECRUITING
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: QBX (5F/6F) Peripheral Balloon Expandable Stent System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vitamin B12 Supplementation During Pregnancy
Status: COMPLETED
Conditions: Nutritional Anemia in Mothers.|Nutritional Anemia in Infants.
Interventions: DIETARY_SUPPLEMENT: Vitamin B12|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Correlation of VEGF-A and Fluid Balance in Septic Shock
Status: UNKNOWN
Conditions: Septic Shock
Interventions: OTHER: Evaluation of VEGF-A levels in patients with septic shock is positively correlated with a positive fluid balance.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy Study of IL-10 (Tenovil TM) in the Prevention of Post-ERCP Acute Pancreatitis (Study P02580)(TERMINATED)
Status: TERMINATED
Conditions: Bile Duct Diseases|Biliary Tract Diseases|Gallbladder Diseases|Pancreatitis|Pancreatic Diseases
Interventions: DRUG: IL-10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Study Of Pharmacokinetics, Whole Body And Organ Dosimetry, And Biodistribution Of Fission-Derived Iodine I 131 Tositumomab (BEXXAR®) For Patients With Previously Untreated Or Relapsed Follicular Or Transformed Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Follicular
Interventions: BIOLOGICAL: Follicular Lymphoma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Proton and Photon Radiotherapy of Brain Tumors (ProtoChoice-Hirn)
Status: RECRUITING
Conditions: Brain Tumors
Interventions: RADIATION: Radiation with protons|RADIATION: Radiation with photons
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Pilot Study of Mixed Chimerism to Treat Hemoglobinopathies
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: BIOLOGICAL: Enriched Hematopoetic Stem Cell Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Co-infections of HIV-1 and Schistosoma Mansoni and Its Impact on Praziquantel Treatment Outcomes
Status: UNKNOWN
Conditions: Anemia|Intestinal Helminthiasis|Intestinal Schistosomiasis|Human Immunodeficiency Virus I Infection|Hematologic Diseases|Opportunistic Infections
Interventions: DRUG: Praziquantel and Albendazole|DRUG: Praziquantel and Albendazole|DRUG: Praziquantel and Albendazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Modified Constraint Induced Movement Therapy in Children With Obstetric Brachial Plexus Injury
Status: COMPLETED
Conditions: Obstetric; Injury
Interventions: OTHER: Conventional physical therapy treatment|OTHER: Constraint induced movement therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adaptive SCS for Treatment of Gait Disturbance in PD
Status: UNKNOWN
Conditions: Gait Disorders, Neurologic|Parkinson Disease
Interventions: DEVICE: sensor-driven position-adaptive SCS|DEVICE: conventional SCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Adaptive Randomized Trial of Bevacizumab Versus Bevacizumab Plus Vorinostat in Adults With Recurrent Glioblastoma
Status: COMPLETED
Conditions: Malignant Glioma|Recurrent Glioblastoma
Interventions: DRUG: vorinostat|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrauterine Tamponade With a Belfort-Dildy Balloon in the Treatment of Immediate Postpartum Hemorrhage
Status: COMPLETED
Conditions: Immediate Postpartum Hemorrhage
Interventions: DEVICE: Early Belfort-Dildy Balloon|DEVICE: Late Belfort-Dildy balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sowing the Seeds of Confidence: Brief Online Group Parenting Programme for Anxious Parents of 1-3 Year Olds
Status: COMPLETED
Conditions: Anxiety|Parenting
Interventions: BEHAVIORAL: Parenting programme (cognitive behavioural) aimed at reducing generational transmission of anxiety
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intracerebral EGFR-vIII CAR-T Cells for Recurrent GBM
Status: TERMINATED
Conditions: Recurrent Glioblastoma|Recurrent Gliosarcoma
Interventions: BIOLOGICAL: EGFRvIII-CARs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crossover Study to Evaluate the Comparative Bioavailability of Two Fixed Dose Combination Tablet Formulations of Amlodipine and Losartan in Health Volunteers
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Reference Treatment: 1 x 5mg amlodipine tablet and 1 x 100mg losartan tablet administered in fasted state|DRUG: Fixed Dose Combination 1: 1 x 5mg amlodipine / 100mg losartan tablet administered in fasted state|DRUG: Fixed Dose Combination 2: 1 x 5mg amlodipine / 100mg losartan tablet administered in fasted state
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melatonin and Sleep in Preventing Delirium in the Hospital
Status: COMPLETED
Conditions: Delirium
Interventions: DIETARY_SUPPLEMENT: Melatonin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate IBI112 in the Treatment of Subjects With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: IBI112 dose 2|DRUG: IBI112 dose 4|DRUG: IBI112 dose 1|DRUG: IBI112 dose 3|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Functional Roles of Dorsolateral Prefrontal Cortex
Status: UNKNOWN
Conditions: Healthy Participants
Interventions: OTHER: Theta Burst Transcranial Magnetic Stimulation|OTHER: Focused Ultrasound|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Preoperative Topical Gatifloxacin on Anterior Chamber Cultures After Cataract Surgery
Status: WITHDRAWN
Conditions: Endophthalmitis
Interventions: DRUG: gatifloxacin ophthalmic (ZYMAR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Optimizing Antitumor Immunity Using Plasmid Electroporation, Pembrolizumab, and Epacadostat
Status: TERMINATED
Conditions: Metastatic Head and Neck Squamous Cell Carcinoma|Recurrent Head and Neck Squamous Cell Carcinoma|Unresectable Head and Neck Squamous Cell Carcinoma
Interventions: DEVICE: ImmunoPulse|DRUG: Epacadostat|DRUG: Pembrolizumab|BIOLOGICAL: CORVax|DRUG: Tavokinogene telseplasmid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Immunogenicity, Reactogenicity and Safety of HBV-MPL Vaccine vs Engerix™-B, in Haemodialysis Patients
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: HBV-MPL vaccine 208129|BIOLOGICAL: Engerix™-B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Redox Status and Immune Function
Status: COMPLETED
Conditions: Skeletal Muscle Damage|Aseptic Inflammation|Skeletal Muscle Function
Interventions: DIETARY_SUPPLEMENT: n-acetylcysteine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: ANTERO-4: VIPUN Gastric Monitoring System in an Erythromycin Model
Status: TERMINATED
Conditions: Gastric Motility
Interventions: DEVICE: VIPUN GMS|DRUG: Erythromycin Lactobionate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immunogenicity and Safety Study of Adjuvanted SARS-CoV-2 (SCB-2019) Vaccine in Adultsin China
Status: UNKNOWN
Conditions: COVID-19
Interventions: BIOLOGICAL: Candidate Vaccine, SCB-2019|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Extended Release Exenatide Versus Placebo In Diabetic Patients With Type 4 Cardiorenal Syndrome
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Chronic Kidney Disease|Left Ventricular Diastolic Dysfunction
Interventions: DRUG: BYDUREON|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aging Intervention for MCI Population: The AIM Pilot Study
Status: RECRUITING
Conditions: Cognitive Impairment|Cognitive Decline
Interventions: DEVICE: Active tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of MND-2119 in Participants With Hypertriglyceridemia
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DRUG: Icosapent (MND-2119)|DRUG: Icosapent (EPADEL CAPSULES 300)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glucose Tolerance in Healthy Overweight Adults
Status: COMPLETED
Conditions: Overweight
Interventions: OTHER: Amino Acid Drink Mixture|OTHER: Glucose drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of APRV vs. LTV on Right Heart Function in ARDS Patients: a Single-center Randomized Controlled Study
Status: UNKNOWN
Conditions: Right Heart Failure|Mechanical Ventilation|Acute Respiratory Distress Syndrome
Interventions: PROCEDURE: Airway pressure release ventilation|PROCEDURE: low tidal volume
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Designed to Evaluate the Safety and Pharmacokinetics of Intravenously Administered Superoxide Dismutase Mimetic GC4711 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GC4711 30mg|DRUG: GC4711 60mg|DRUG: GC4711 90mg|DRUG: GC4711 120mg|DRUG: Placebo|DRUG: GC4711 75mg|DRUG: GC4711 105mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Stepped-care Metacognition-based Intervention on Managing Fear of Cancer Recurrence
Status: NOT_YET_RECRUITING
Conditions: Cancer|Fear of Cancer Recurrence
Interventions: BEHAVIORAL: eConquerFear|BEHAVIORAL: eHealthMaintenance|BEHAVIORAL: ConquerFear|BEHAVIORAL: eConquerFear+eHealthMaintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety and Efficacy of ABP 501 in Subjects With Moderate to Severe Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: BIOLOGICAL: ABP 501
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sodium Stibogluconate in the MDS/AML With One of the 65 Defined p53 Mutations
Status: UNKNOWN
Conditions: Myelodysplastic Syndromes|Acute Myeloid Leukemia|Myeloid Malignancy|Temperature-Sensitive p53 Mutation|Sodium Stibogluconate|P53 Mutation
Interventions: DRUG: Sodium stibogluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of Decision Support Strategies for Joint Replacement Surgery
Status: COMPLETED
Conditions: Hip Osteoarthritis|Knee Osteoarthritis
Interventions: BEHAVIORAL: Interactive decision aid|BEHAVIORAL: Video decision aid|BEHAVIORAL: Provider Report
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: EF5 to Detect Tumor Hypoxia in Patients With Stage IIB, Stage IIIB, or Stage IVA Cervical Cancer
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: DRUG: EF5|OTHER: immunohistochemistry staining method|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Oxycodone to the Placental Circulation at Early Labour
Status: ACTIVE_NOT_RECRUITING
Conditions: Labor Pain
Interventions: DRUG: Oxycodone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study to Assess Whether Proinsulin Peptide Injections Can Slow or Stop the Body Damaging Its Own Insulin-making Cells in the Pancreas in Patients Newly Diagnosed With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Pro insulin peptide|DRUG: Pro insulin peptide|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zero Degree Knee Positioner for Improved Earley Knee Extension Following Total Knee Arthroplasty
Status: ENROLLING_BY_INVITATION
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Zero Degree Knee Positioner
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The SEPIA-PCI Trial: Otamixaban in Comparison to Heparin in Subjects Undergoing Non-Urgent Percutaneous Coronary Intervention
Status: COMPLETED
Conditions: Angioplasty, Transluminal, Percutaneous Coronary
Interventions: DRUG: Otamixaban (XRP0673)|DRUG: Unfractionated Heparin|PROCEDURE: Percutaneous Coronary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Live Oral Cholera Vaccine, PXVX200 in Healthy Older Adults
Status: COMPLETED
Conditions: Cholera
Interventions: BIOLOGICAL: PXVX0200|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Feasibility and Efficacy Study of the CardioPulmonary Management (CPM) System in Patients With Chronic Heart Failure ( BETA )
Status: RECRUITING
Conditions: Heart Failure
Interventions: DEVICE: CardioPumlonary Management System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multicenter Randomized Trial of Non-inferiority Between Glyburide and Insulin for the Treatment of Gestational Diabetes
Status: COMPLETED
Conditions: Diabetes|Gestational
Interventions: OTHER: Insulin|DRUG: Glyburide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HEMolysis in a Percutaneous Axial Flow LVAD, Effects of Pentoxifylline in a Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Hemolysis Intravascular|Acute Decompensated Heart Failure
Interventions: DRUG: Pentoxifylline Oral Product|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetes Islet Preservation Immune Treatment
Status: WITHDRAWN
Conditions: Diabetes Mellitus, Type 1|Hypoglycemia|Autoimmune Diseases|Diabetes Mellitus
Interventions: DRUG: Anti-Thymocyte Globulin (ATG)|DRUG: Interleukin 2|DRUG: Exenatide|DRUG: Adalimumab|OTHER: ATG Placebo|OTHER: IL-2 Placebo|OTHER: Adalimumab Placebo|OTHER: Exenatide Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postpartum Levonorgestrel-releasing Intrauterine System and Breastfeeding
Status: COMPLETED
Conditions: Postpartum Contraception
Interventions: DRUG: Levonorgestrel-releasing intrauterine system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Surgical Treatment of Peri-implantitis With and Without an Initial Non-surgical Approach
Status: COMPLETED
Conditions: Peri-Implantitis
Interventions: PROCEDURE: Surgery with a previous non-surgical approach|PROCEDURE: Surgery without a previous non-surgical approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous Indwelling of Vacuum Drainage in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Total Knee Arthroplasty
Interventions: PROCEDURE: subcutaneous indwelling|PROCEDURE: intraarticular indwelling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of The Five-Session Dual-tDCS On Lower-Limb Performance in Sub-Acute Stroke
Status: COMPLETED
Conditions: Stroke, Ischemic
Interventions: DEVICE: Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in the Ankle Range of Motion Following Subtalar Joint Manipulation
Status: TERMINATED
Conditions: Ankle Inversion Sprain
Interventions: PROCEDURE: Subtalar joint manipulation|PROCEDURE: Sham subtalar joint manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Combination of Panobinostat & Carfilzomib in Patients With Relapsed &/or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Panobinostat|DRUG: Carfilzomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT