pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Does Higher OT Temperature and IV Ondansetron Reduce Incidence of PSS in Parturients?
Status: UNKNOWN
Conditions: Temperature Change, Body|Chills|Tremor|Nausea, Postoperative|Vomiting, Postoperative|Postoperative Shivering
Interventions: DRUG: IV Ondansetron 4mg|OTHER: Higher OT temperature range|DRUG: Placebo|OTHER: Lower OT temperature Range
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Whole Versus Partial Vertebral Body IMRT for Spinal Metastases
Status: UNKNOWN
Conditions: Pain
Interventions: RADIATION: 10x(3-5) Gy IMRT|RADIATION: 10x3 Gy IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Programs of Coordinated Care and Disease Management
Status: UNKNOWN
Conditions: Congestive Heart Failure|Diabetes|Coronary Artery Disease|Chronic Obstructive Pulmonary Disease|Cancer|Cerebrovascular Disease|Alzheimer's Disease|Psychotic Disorder|Major Depression
Interventions: BEHAVIORAL: Care Coordination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Gingival Health and Malocclusion Among Type 1 Diabetic Children and Adolescents
Status: ACTIVE_NOT_RECRUITING
Conditions: Gingivitis|Periodontal Diseases|Diabetes|Diabetes Mellitus, Type 1|Malocclusion|Malocclusion in Children
Interventions: PROCEDURE: Periodontal therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Oral Nutrition Supplements in Children With Disease Associated Underweight
Status: COMPLETED
Conditions: Disease Associated Underweight
Interventions: DIETARY_SUPPLEMENT: The ONS provided to the children intervention group will be a ready to drink age adapted oral nutrition supplement providing 1,5 kcal/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Cryotherapy on Taxane-Induced Neuropathy in Patients With Breast Cancer
Status: RECRUITING
Conditions: CIPN - Chemotherapy-Induced Peripheral Neuropathy|Breast Cancer
Interventions: DEVICE: Elasto-Gel™ mitts for hands: TM7008, and slippers for feet: SL3000; Southwest Technologies, Inc., North Kansas City, MO, USA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Hypoxia During Gastroenterological Endoscope Procedures Sedated With Ciprofol In Overweight Or Obesity Patients
Status: COMPLETED
Conditions: Gastric Ulcer|Gastric Cancer|Gastrointestinal Polyp
Interventions: DRUG: Ciprofol|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Penicillin Allergy Clinical Decision Rule to Enable Direct Oral Penicillin Challenge
Status: COMPLETED
Conditions: Hypersensitivity, Immediate|Hypersensitivity, Delayed|Hypersensitivity Response
Interventions: OTHER: Direct oral penicillin challenge|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Enhanced Recovery After Surgery (ERAS) on C-reactive and Visceral Proteins
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: PROCEDURE: ERAS protocols|PROCEDURE: ERAS protocols|PROCEDURE: ERAS protocols|PROCEDURE: ERAS protocols|PROCEDURE: ERAS protocols|PROCEDURE: ERAS protocols|PROCEDURE: ERAS protocols|PROCEDURE: ERAS protocols|PROCEDURE: ERAS protocols|PROCEDURE: ERAS protocols|PROCEDURE: ERAS protocols|PROCEDURE: conventional pathway group|PROCEDURE: conventional pathway group|PROCEDURE: conventional pathway group|PROCEDURE: conventional pathway group|PROCEDURE: conventional pathway group|PROCEDURE: conventional pathway group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Genetically Engineered Natural Killer (NK) Cells With or Without Atezolizumab for the Treatment of Non-small Cell Lung Cancer Previously Treated With PD-1 and/or PD-L1 Immune Checkpoint Inhibitors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lung Non-Small Cell Carcinoma|Metastatic Lung Non-Small Cell Carcinoma|Recurrent Lung Non-Small Cell Carcinoma|Refractory Lung Non-Small Cell Carcinoma|Stage III Lung Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|Stage IIIC Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: BIOLOGICAL: Antineoplastic Immune Cell|BIOLOGICAL: Atezolizumab|PROCEDURE: Biospecimen Collection|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Idiopathic Granulomatous Mastitis Combination Therapy
Status: UNKNOWN
Conditions: Idiopathic Granulomatous Mastitis
Interventions: PROCEDURE: Intralesional steroid administration|PROCEDURE: Intraoperative cavity steroid administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nimotuzumab Combined With GX as Postoperative Adjuvant Therapy in Pancreatic Cancer
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Nimotuzumab|DRUG: GX|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comprehensive Geriatric Assessment in the Monitoring of Functional Improvement
Status: COMPLETED
Conditions: Aging|Vestibular Disorder|Physiotherapy|Physical Activity
Interventions: OTHER: multi component exercise in the clinic|OTHER: vestibular exercise in the clinic|OTHER: vestibular exercise at home telerehabilitation|OTHER: multi component exercise at home telerehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Two Different Starting Doses of Methotrexate When Starting Treatment in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cerclage On LOw Risk Singletons: Cervical Cerclage for Prevention of Spontaneous Preterm Birth in Low Risk Singleton Pregnancies With Short Cervix
Status: COMPLETED
Conditions: Premature Birth
Interventions: PROCEDURE: Cervical cerclage|DRUG: Vaginal progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antihypertensive Efficacy and Safety of Candesartan/HCT 32/12.5 and 32/25 mg in Comparison With Candesartan 32 mg
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Candesartan cilexetil|DRUG: Hydrochlorothiazide|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Examining the Effect of a Scripted Debriefing on Resuscitation Performance in Pediatrics
Status: COMPLETED
Conditions: Pediatric Cardiac Arrest (Simulated)
Interventions: OTHER: Debriefing Script|OTHER: High Physical Realism Simulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Effect of mCPP on Cognitive Control, Appetite, and Neural Responses
Status: TERMINATED
Conditions: Eating Behavior|Obesity
Interventions: DRUG: mCPP|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fractional CO2 Laser Fenestration and Steroid Delivery in HS Lesions
Status: NOT_YET_RECRUITING
Conditions: Scar|Hidradenitis Suppurativa
Interventions: DEVICE: Triamcinolone Topical|PROCEDURE: Fractional Ablative CO2 Therapy|DRUG: EMLA 5% cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of Pharmacogenomics for Treatment of Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: OTHER: GeneSight Psychotropic test|OTHER: Canadian Network for Mood and Anxiety Treatment (CANMAT) Best Practice Guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effects of CBP-307 on the Heart Rate-corrected QT Interval (QTc) in Healthy Subjects
Status: COMPLETED
Conditions: Autoimmune Diseases
Interventions: DRUG: CBP-307|DRUG: Placebo-matched CBP-307|DRUG: Moxifloxacin (Avelox)|DRUG: Placebo-matched Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Colchicine Protective Effect in Patients Undergoing Percutaneous Coronary Intervention (COLCHICINE-PROTECT)
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DRUG: Colchicine 0.5 MG Oral Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment Frequency Reduction in Pompe Disease
Status: NOT_YET_RECRUITING
Conditions: Pompe Disease (Late-onset)|GAA Deficiency|Glycogen Storage Disease Type II|Acid Maltase Deficiency
Interventions: DRUG: Algucosidase alfa 20 mg/kg once every 4 weeks instead of once every 2 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Immunosuppression Minimization in Children and Adolescents After Kidney Transplantation
Status: COMPLETED
Conditions: Kidney Failure, Chronic|Kidney Transplantation|Immunosuppression
Interventions: DRUG: Sirolimus|DRUG: MMF or Azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of an Oxygen-nitrous Oxide Mixture During Physical Therapy for Frozen Shoulder
Status: COMPLETED
Conditions: Adhesive Capsulitis
Interventions: DRUG: equimolar oxygen-nitrous oxide mixture|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: P1101 in Treating Patients With Myelofibrosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Myelofibrosis|Secondary Myelofibrosis
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|BIOLOGICAL: Ropeginterferon Alfa-2B
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Trial to Assess the Efficacy and Toxicity of ASTX727 (Oral Decitabine/Cedazuridine) for the Treatment of Hematological Neoplasms After Allogeneic Stem Cell Transplantation
Status: WITHDRAWN
Conditions: Allogeneic Stem Cell Transplantation
Interventions: DRUG: ASTX727|DRUG: Donor Lymphocyte Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phamacokinetic and Pharmacodynamic Study of Ramosetron in Chemotherapy Induced Nasea and Vomiting
Status: COMPLETED
Conditions: Colon Cancer
Interventions: DRUG: Ramosetron 0.3mg|DRUG: Ramosetron 0.45mg|DRUG: Ramosetron 0.6mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer
Status: COMPLETED
Conditions: Stage-Ⅱ Colorectal Cancer
Interventions: DRUG: Orectalip
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Levoﬂoxacin and Bismuth-containing Therapy Versus Quadruple Therapy as Second-line Treatment of Resistant Helicobacter Pylori Infection
Status: COMPLETED
Conditions: Cure Rate of Helicobacter Pylori Infection
Interventions: DRUG: Proton pump inhibitor|DRUG: Bismuth subsalicylate|DRUG: Metronidazole|DRUG: Tetracycline|DRUG: Amoxicillin|DRUG: Levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NexGen Gender Fixed Bearing Knee Versus NexGen Legacy Knee Posterior Stabilized (LPS) - Flex Fixed Bearing Knee: A Study Comparing Two Different Knee Prostheses
Status: UNKNOWN
Conditions: Total Knee Arthroplasty
Interventions: DEVICE: NexGen Gender Fixed Bearing Knee prosthesis|DEVICE: NexGen LPS-Flex Fixed Bearing Knee prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Jinsang Liyan Capsules Combined With PPI in the Treatment of LPRD
Status: RECRUITING
Conditions: Laryngopharyngeal Reflux
Interventions: DRUG: Jinsang Liyan Capsule; Rabeprazole enteric-coated tablets.|DRUG: Jinsang Liyan Capsule placebo; Rabeprazole enteric-coated tablets.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Losartan Versus Amlodipine-based Therapy in Ischemic Stroke (0954-338)(COMPLETED)
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: losartan|DRUG: amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of N-acetylcysteine Infusion and Intralipid Infusion on Myocardial Injury in Aluminum Phosphide Toxicity
Status: NOT_YET_RECRUITING
Conditions: Myocardial Injury
Interventions: DRUG: N-acetyl cysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intensity-Modulated Radiation Therapy, Cisplatin, and Bevacizumab Followed by Carboplatin and Paclitaxel in Treating Patients Who Have Undergone Surgery for Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Adenocarcinoma|Endometrial Adenosquamous Carcinoma|Endometrial Clear Cell Adenocarcinoma|Endometrial Serous Adenocarcinoma|Stage IA Uterine Corpus Cancer AJCC v7|Stage IB Uterine Corpus Cancer AJCC v7|Stage II Uterine Corpus Cancer AJCC v7|Stage IIIA Uterine Corpus Cancer AJCC v7|Stage IIIB Uterine Corpus Cancer AJCC v7|Stage IIIC Uterine Corpus Cancer AJCC v7|Stage IVA Uterine Corpus Cancer AJCC v7|Stage IVB Uterine Corpus Cancer AJCC v7
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Carboplatin|DRUG: Cisplatin|RADIATION: Intensity-Modulated Radiation Therapy|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Residual Capacity Under Apnoeic Oxygenation With Different Flow Rates in Children
Status: COMPLETED
Conditions: Apnea|Anesthesia|Intubation Complication|Children, Only|Apnea Infant|Atelectasis|Ventilation Therapy; Complications
Interventions: OTHER: 0.2 L/kg/min, FiO2 1.0 + continuous jaw thrust|OTHER: 2 L/kg/min, FiO2 1.0 + continuous jaw thrust|OTHER: 4 L/kg/min, FiO2 1.0 + continuous jaw thrust|OTHER: 2 L/kg/min using OptiFlow-Switch system, FiO2 1.0 + continuous jaw thrust
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Haploinsufficiency of the RBM22 and SLU7 Genes in Del(5q) Myelodysplastic Syndromes
Status: UNKNOWN
Conditions: Myelodysplastic Syndromes|Myelodysplastic Syndrome With Isolated Del(5Q)|Myelodysplastic Syndrome With Del(5Q)
Interventions: GENETIC: somatic cytogenetic and genetic characterization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Compare the Efficacy and Safety of HRS9531 and Placebo in Subjects With Overweight or Obese
Status: RECRUITING
Conditions: Overweight or Obesity
Interventions: DRUG: HRS9531 injection|DRUG: HRS9531 injection|DRUG: HRS9531 injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Potential of Brillouin Microscopy for Biomechanical Properties Measurements in Human Cornea
Status: COMPLETED
Conditions: Pellucid Marginal Corneal Degeneration|Keratoconus|Keratectasia
Interventions: DEVICE: Brillouin Ocular Scanner
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Ocular Penetration of Topically Administered Fluoroquinolones
Status: COMPLETED
Conditions: Cataract Extraction
Interventions: DRUG: Moxifloxacin 0.5% ophthalmic solution|DRUG: Besifloxacin 0.6% ophthalmic suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Dose-Range Finding Study of SUN-101 in Subjects With Moderate to Severe COPD
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Placebo|DRUG: SUN101 3 mcg|DRUG: SUN-101 6.25 mcg|DRUG: SUN-101 12.5 mcg|DRUG: SUN-101 50 mcg|DRUG: Aclidinium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Different Ventilation Modes on Patients With Pulmonary Lobe Resection
Status: RECRUITING
Conditions: Lung Injury|Lung Inflammation
Interventions: PROCEDURE: Adopting different ventilation modes during the operation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Rhabdoid Tumor|Atypical Teratoid Rhabdoid Tumor
Interventions: DRUG: alisertib|DRUG: methotrexate|DRUG: cisplatin|DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: topotecan|DRUG: vincristine|PROCEDURE: Surgical resection|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Trans Sodium Crocetinate (TSC) for Treatment of Suspected Stroke
Status: TERMINATED
Conditions: Stroke, Acute
Interventions: DRUG: Trans-Sodium Crocetinate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Testosterone Replacement on Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Hypogonadotrophic Hypogonadism
Status: COMPLETED
Conditions: Hypogonadotrophic Hypogonadism
Interventions: DRUG: Testogel 50 mg transdermal gel|DRUG: Testosterone 250mg injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 4 mg Nicotine Polacrilex Gum and Swedish Portion Snus
Status: COMPLETED
Conditions: Healthy Subjects|Smokers
Interventions: DRUG: Nicotine|DRUG: Nicotine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Drug-drug Interaction (DDI) Study of Spironolactone (Perpetrator) and Digoxin (Substrate Drug)
Status: COMPLETED
Conditions: Drug Drug Interaction
Interventions: DRUG: Digoxin 250 MCG Oral Tablet|DRUG: Spironolactone 25 mg/ 5 mL S/F Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Ratio of Hypnotic to Analgesic Potency of Volatile Anesthetics
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Sevoflurane|DRUG: Isoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Double-blind, Placebo-randomized Controlled Clinical Study on the Treatment of Non-alcoholic Steatohepatitis With Tibetan Drug Langqing Atar
Status: RECRUITING
Conditions: NASH
Interventions: DRUG: Lang Qingata|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Prospective Post-registration Study of Empegfilgrastim to Evaluate Safety and Efficacy in Special Cancer Populations
Status: UNKNOWN
Conditions: Solid Tumor|High-Risk Cancer|Breast Cancer|Gastrointestinal Cancer|Gynecological Malignancies|Myelosuppression
Interventions: DRUG: Empegfilgrastim
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of the Safety, Tolerability, and Effectiveness of Rifapentine Given Daily for LTBI
Status: RECRUITING
Conditions: Latent Tuberculosis
Interventions: DRUG: Rifapentine daily for 6 weeks|DRUG: Rifapentine and Isoniazid weekly for 12 weeks|DRUG: Rifampin and Isoniazid daily for 12 weeks|DRUG: Rifampin daily for 16 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Three Treatments for Advanced HIV Disease in Patients Who Have Received Nucleoside Therapy in the Past
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zidovudine|DRUG: Zalcitabine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Treadmill With Ankle Weights on Balance in Spastic Cerebral Palsied Children
Status: UNKNOWN
Conditions: Cerebral Palsy
Interventions: OTHER: Physical therapy program with treadmill training without using of ankle weights.|OTHER: Physical therapy program with treadmill training with using of ankle weights.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Eltrombopag for Promoting Thrombopoiesis After Total Body Irradiation
Status: COMPLETED
Conditions: Thrombocytopenia|Acute Radiation Syndrome
Interventions: DRUG: Eltrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of Tanezumab as Add-On Therapy to Opioid Medication In Patients With Pain Due To Cancer That Has Spread To Bone
Status: COMPLETED
Conditions: Neoplasm Metastasis|Palliative Care
Interventions: DRUG: Tanezumab 10 mg IV|DRUG: IV Placebo for tanezumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing BL-B01D1 With Docetaxel in Patients With Unresectable Locally Advanced or Metastatic EGFR Wild-type Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: BL-B01D1|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interferon-Beta-1a (FP-1201) to Prevent Toxicities After CD19-Directed CAR T-Cell Therapy
Status: WITHDRAWN
Conditions: Recurrent B Acute Lymphoblastic Leukemia|Recurrent B-Cell Non-Hodgkin Lymphoma|Refractory B Acute Lymphoblastic Leukemia|Refractory B-Cell Non-Hodgkin Lymphoma|Recurrent Mantle Cell Lymphoma|Refractory Mantle Cell Lymphoma
Interventions: BIOLOGICAL: Interferon Beta-1A|PROCEDURE: X-Ray Imaging|PROCEDURE: Echocardiography|PROCEDURE: Multigated Acquisition Scan|PROCEDURE: Computed Tomography|PROCEDURE: Positron Emission Tomography|PROCEDURE: Lumbar Puncture|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Prophylactic Medical Compression Therapy on the Reduction of Breast Cancer-related Lymphedema in Patients With Adjuvant Docetaxel Chemotherapy: a Randomized Controlled Study
Status: RECRUITING
Conditions: Breast Cancer Lymphedema
Interventions: DEVICE: Medical compression stocking (medical device name: mediven Harmony 734 (compression class1 AG armsleeve or with wide(735))
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Transcutaneous Bilirubinometry and Phototherapy
Status: NOT_YET_RECRUITING
Conditions: Neonatal Hyperbilirubinemia
Interventions: DIAGNOSTIC_TEST: Transcutaneous bilirubinometry|DIAGNOSTIC_TEST: Serum bilirubin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Pre-emptive Quadratus Lumborum Block for Laparoscopic Bariatric Surgery
Status: COMPLETED
Conditions: Pain|Postoperative
Interventions: PROCEDURE: US-guided Quadratus lumborum block.|DRUG: Bupivacaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Comparing the Efficacy and Safety of Etrolizumab With Adalimumab and Placebo in Participants With Moderate to Severe Ulcerative Colitis (UC) in Participants Naive to Tumor Necrosis Factor (TNF) Inhibitors
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Adalimumab|OTHER: Adalimumab Placebo|DRUG: Etrolizumab|OTHER: Etrolizumab Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pomalidomide (CC-4047) to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Effectiveness for Patients With Systemic Sclerosis With Interstitial Lung Disease
Status: TERMINATED
Conditions: Scleroderma, Systemic|Sclerosis, Systemic|Systemic Scleroderma|Systemic Sclerosis|Interstitial Lung Disease
Interventions: DRUG: Pomalidomide (CC-4047)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: M-Tapa Block for Laparoscopic Cholesistectomy
Status: COMPLETED
Conditions: Cholecystitis|Cholecystitis, Acute|Cholecystitis, Chronic
Interventions: DRUG: M TAPA block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Alternating Current Stimulation (tACS) to Improve Motor Skill Acquisition in Stroke Patients
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: TGP-tACS|DEVICE: Sham-tACS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Oral Bicarbonate as Adjuvant for Pain Reduction in Patients With Tumor Related Pain
Status: TERMINATED
Conditions: Tumor|Cancer|Pain|Malignant Solid Tumor|Unresectable Malignant Neoplasm|Hematologic Malignancy|Multiple Myeloma|Lymphoma|Neoplasm Metastasis
Interventions: DRUG: Sodium Bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Anterior Lamellar Recession vs Bilamellar Tarsal Rotation in Upper Lid Cicatricial Trichiasis
Status: COMPLETED
Conditions: Cicatricial Trichiasis
Interventions: PROCEDURE: Anterior Lamellar Recession|PROCEDURE: Bilamellar Tarsal Rotation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pediatric Long-Term Follow-up and Rollover Study
Status: RECRUITING
Conditions: Diffuse Astrocytoma|Anaplastic Astrocytoma|Astrocytoma|Oligodendroglioma, Childhood|Anaplastic Oligodendroglioma|Glioblastoma|Pilocytic Astrocytoma|Giant Cell Astrocytoma|Pleomorphic Xanthoastrocytoma|Anaplastic Pleomorphic Xanthoastrocytoma|Angiocentric Glioma|Chordoid Glioma of Third Ventricle|Gangliocytoma|Ganglioglioma|Anaplastic Ganglioglioma|Dysplastic Gangliocytoma of Cerebrellum|Desmoplastic Infantile Astrocytoma and Ganglioglioma|Papillary Glioneuronal Tumor|Rosette-forming Glioneurona Tumor|Central Neurocytoma|Extraventricular Neurocytoma|Cerebellar Liponeurocytoma|Neurofibromatosis Type 1
Interventions: DRUG: dabrafenib|DRUG: trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine Final Geriatric Assessment in Haematology (GAH) Score as a Tool for Predicting Tolerance to Treatment in Elderly Patients (≥ 65 Years) With Haematologic Neoplasms
Status: COMPLETED
Conditions: Myelodysplastic Syndromes|Leukemia Myeloid Acute|Multiple Myeloma|Leukemia, Lymphocytic, Chronic, B-Cell
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tolerability and Lipid Lowering Effect of Weekly/Biweekly Crestor in Statin Intolerant Patients Treated With Zetia
Status: UNKNOWN
Conditions: Hypercholesterolemia
Interventions: DRUG: Rosuvastatin|DRUG: Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Sequential Therapy in Multiple Myeloma Guided by MRD Assessments
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Dara-VRd intensification, Dara-R maintenance|DRUG: AHCT intensification, Dara-R maintenance|DRUG: AHCT intensification, Tec-Dara consolidation, Tec-Dara maintenance|DRUG: AHCT intensification, Dara-R consolidation, Dara-R maintenance|DRUG: Dara-VRd induction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Post-Vaccination Presyncope and Syncope in Adolescents Using Simple, Clinic-based Interventions: A Pilot Study
Status: COMPLETED
Conditions: Syncope, Vasovagal
Interventions: DEVICE: Buzzy®|BEHAVIORAL: Music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Pharmacokinetic Study for PCA Derivate Formulations
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PCA|DRUG: PCA|DRUG: PCA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Cetrorelix and Ganirelix Flexible Protocol for (IVF)
Status: UNKNOWN
Conditions: Infertility/Sterility
Interventions: DRUG: Ganirelix Acetate|DRUG: Cetrorelix Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fraction
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Omecamtiv Mecarbil|DRUG: Placebo|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pregnyl as Adjunct Therapy for High-Risk or Refractory Acute GVHD
Status: COMPLETED
Conditions: Graft vs Host Disease
Interventions: DRUG: Pregnyl®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hypertonic Saline to Reduce Hospital Admissions in Bronchiolitis
Status: COMPLETED
Conditions: Viral Bronchiolitis
Interventions: DRUG: solution contains 1 mg salbutamol plus 3% hypertonic saline|DRUG: solution contains 1 mg salbutamol plus 0.9% saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reacto & Immunogenicity of TF Formulation of Influsplit SSW® 2002/03 v/s Std Formulation of Influsplit SSW® 2002/03
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Thiomersal free trivalent influenza split vaccine 2002/2003|BIOLOGICAL: GlaxoSmithKline Biologicals' Influsplit SSW®/Fluarix™ 2002/2003
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Developing School Health Champions to Increase Health Literacy Both in School Adolescents and Community People Through Providing Health Education by the School Nurses in Bangladesh: Community-based Pre- and Post-experimental Design
Status: RECRUITING
Conditions: Health Literacy
Interventions: OTHER: pre and post test (health educational intervention)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Myocardial Fibrosis and Inflammation in Liver Cirrhosis
Status: COMPLETED
Conditions: Cirrhosis, Liver|Cardiomyopathies|Portal Hypertension
Interventions: PROCEDURE: Transjugular intrahepatic portosystemic shunt implantation|DIAGNOSTIC_TEST: Magnetic resonance imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Probiotic Formula on Reducing the Risk for Antibiotic-associated Diarrhoea
Status: TERMINATED
Conditions: Antibiotic-associated Diarrhoea
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy and Filgrastim or Pegfilgrastim in Treating Patients With Recurrent or Persistent Cancer of the Uterus
Status: COMPLETED
Conditions: Recurrent Uterine Corpus Sarcoma|Uterine Corpus Leiomyosarcoma
Interventions: DRUG: Docetaxel|BIOLOGICAL: Filgrastim|DRUG: Gemcitabine Hydrochloride|BIOLOGICAL: Pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vanguard TKA With KneeAlign 2 and Without KneeAlign 2
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: KneeAlign 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study Comparing Full-dose Radiotherapy Versus Reduced Dose in the Management of Bone Metastasis in Patients With Breast Cancer Receiving Zoledronic Acid
Status: COMPLETED
Conditions: Breast Cancer With Metastatic Bone Disease
Interventions: DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patients With ES-SCLC and ECOG PS=2 Receiving Atezolizumab-Carboplatin-Etoposide
Status: ACTIVE_NOT_RECRUITING
Conditions: SCLC, Extensive Stage
Interventions: DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REDucing Hot FLASHes in Women Using Endocrine Therapy.
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Hot Flash Due to Medication
Interventions: DRUG: Oxybutynin|DRUG: Venlafaxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Performance of a New 1-piece Ostomy Product Compared to Standard Care Ostomy Products in Subjects Ileostomy
Status: WITHDRAWN
Conditions: Leakage|Skin Condition
Interventions: DEVICE: Standard Care|DEVICE: River
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory RCT of a Psychosocial Group Intervention for Epilepsy
Status: UNKNOWN
Conditions: Epilepsy
Interventions: BEHAVIORAL: Psychosocial Intervention Group|OTHER: Waiting list control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of SPI (Surgical Pleth Index) - Guided Anaesthesia on Opioid Consumption in Gastric Sleeve Surgery
Status: RECRUITING
Conditions: Intraoperative Monitoring
Interventions: OTHER: Intra-operative analgesia guided by SPI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study for Pre-diabetic Patients With Cholesterol Lowering Drugs
Status: COMPLETED
Conditions: Pre-diabetes
Interventions: DRUG: Rosiglitazone|DRUG: Placebo Rosiglitazone|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Prospective, Randomized, Multicenter, Open Label, Phase II Study to Access Efficacy and Safety of Lucentis® Monotherapy Compared With Lucentis® Plus Panretinal Photocoagulation (PRP) and PRP in the Treatment of Patients With High Risk Proliferative Diabetic Retinopathy
Status: COMPLETED
Conditions: High Risk Proliferative Diabetic Retinopathy
Interventions: PROCEDURE: Panretinal Photocoagulation (PRP)|DRUG: Intravitreous injection of ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibrutinib in Treating Patients With Relapsed or Refractory Classical Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Classical Hodgkin Lymphoma|Recurrent Hodgkin Lymphoma|Refractory Hodgkin Lymphoma
Interventions: DRUG: Ibrutinib|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Relative Bioavailability of Two Risankizumab Drug Product Presentations in Healthy Volunteers.
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Risankizumab Dose A|DRUG: Risankizumab Dose B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Effectiveness of Adding Saquinavir (FORTOVASE) in Soft Gel Capsule Form to an Anti-HIV Drug Combination in HIV-Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Saquinavir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-nasal vs. Intra-venous Ketamine Administration
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Placebo|DRUG: Ketamine (1st phase)|DRUG: Ketamine (2st phase)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Incidence of Caries in Pits and Fissures Sealed With Bioactive Sealant Compared to Fluoride Releasing Resin Based Pit and Fissure Sealant
Status: UNKNOWN
Conditions: Pit and Fissure Caries
Interventions: OTHER: Embrace™ WetBond™ Pit & Fissure Sealant|OTHER: Seal-Rite™ Pit & Fissure Sealant, Pulpdent Corportation, USA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Global Study Looking at the Combination of RAD001 Plus Best Supportive Care (BSC) and Placebo Plus BSC to Treat Patients With Advanced Hepatocellular Carcinoma.
Status: COMPLETED
Conditions: Carcinoma
Interventions: DRUG: Everolimus|DRUG: Everolimus Placebo|OTHER: Best Supportive Care (BSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Stimulation for Essential Tremor
Status: TERMINATED
Conditions: Essential Tremor
Interventions: DEVICE: Transcranial Magnetic Stimulation|DEVICE: Sham Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: INO-4201 as Booster in Healthy VSV-ZEBOV Vaccinees
Status: COMPLETED
Conditions: Ebola Virus Disease
Interventions: BIOLOGICAL: INO-4201|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Complete Nerve-Sparing Radical Hysterectomy for Cervical Cancer
Status: COMPLETED
Conditions: Cervical Squamous Cell Carcinoma|Cervical Adenocarcinoma|Malignant Neoplasm of Cervix Stage IB1|Stage IIA1 Cervical Cancer
Interventions: PROCEDURE: Nerve-Sparing Radical Hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shear Wave Elastography for Carotid Atherosclerotic Plaques
Status: RECRUITING
Conditions: Carotid Atherosclerosis
Interventions: DIAGNOSTIC_TEST: Vascular Ultrasound|DIAGNOSTIC_TEST: Shear Wave Elastography|DIAGNOSTIC_TEST: Greyscale Median|DIAGNOSTIC_TEST: Magnetic Resonance Imaging|DIAGNOSTIC_TEST: Histopathology
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Time-Restricted Eating for Type II Diabetes: TRE-T2D
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Time Restricted Feeding|Diabetes type2
Interventions: BEHAVIORAL: Time-Restricted Eating|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Renal Function of Young (18-45 Years) and Ageing (55 Years and Above) Kidney Donors
Status: COMPLETED
Conditions: Kidney Diseases
Interventions: PROCEDURE: CT angiogram of the remaining kidney.|PROCEDURE: Kidney Function study using Iothalamate & PAH as clearance markers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An mHealth Strategy to Reduce Pre-Eclampsia and Infant Death in Tanzania
Status: COMPLETED
Conditions: Pre-Eclampsia|Eclampsia|Hypertension, Pregnancy-Induced
Interventions: OTHER: Community-based Pre-eclampsia/Eclampsia Detection and Management|OTHER: Strengthened Referral Network from Community to Referral hospital levels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Hepatocellular Carcinoma Treated With Iodine-125 Implantation
Status: COMPLETED
Conditions: Liver Carcinoma
Interventions: PROCEDURE: Radiofrequency Ablation|RADIATION: iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DuraGen Plus® Adhesion Barrier for Use in Spinal Surgery
Status: TERMINATED
Conditions: Spinal Injuries|Adhesions
Interventions: DEVICE: DuraGen Plus Adhesion Barrier Matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Chronic Kidney Disease (CKD) Not on Dialysis
Status: COMPLETED
Conditions: Hyperphosphatemia
Interventions: DRUG: Fosrenol (Lanthanum Carbonate, BAY77-1931)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Macroglobulinemic Lymphoma With 2CdA, Cyclophosphamide and Rituximab
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: 2CdA|DRUG: Cyclophosphamide|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Botulinum Toxin Type A for the Treatment of Focal Upper Limb Poststroke Spasticity
Status: COMPLETED
Conditions: Stroke|Muscle Spasticity
Interventions: BIOLOGICAL: Botulinum Toxin Type A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: tDCS and Speech Therapy for Motor Speech Disorders Caused by FTLD Syndromes: a Feasibility Study
Status: WITHDRAWN
Conditions: Nonfluent Aphasia, Progressive|Primary Progressive Nonfluent Aphasia|Primary Progressive Non Fluent Aphasia|Progressive Supranuclear Palsy|Corticobasal Degeneration|Behavioral Variant of Frontotemporal Dementia
Interventions: DEVICE: Halo Neuroscience Neurostimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Prospective Multi-dose Study of Apixaban in Subjects With Nephrotic Syndrome
Status: COMPLETED
Conditions: Nephrotic Syndrome|Membranous Nephropathy
Interventions: DRUG: Apixaban 5 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT