pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: MONITOR-OA: Using Wearable Activity Trackers to Improve Physical Activity in Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis|Joint Diseases
Interventions: BEHAVIORAL: Education session, Fitbit Flex, and remote coaching by a PT|BEHAVIORAL: Same intervention with a 2 month delay
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Transanal Resection of Rectal Lesions With the ColubrisMX ELS System
Status: ACTIVE_NOT_RECRUITING
Conditions: Rectal Adenoma|Rectal Polyp|Rectal Lesion
Interventions: DEVICE: ColubrisMX Endoluminal Surgical (ELS) System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ANTIBODY BASED TESTS FOR SARSCoV-2 COVID-19) - Evaluation of Patients and Healthcare Providers in the Confines of Healthcare Settings
Status: UNKNOWN
Conditions: Covid19
Interventions: DIAGNOSTIC_TEST: CoronaCideTM COVID-19 IgM/IgG Rapid Test and Premier Biotech COVID-19 IgM/IgG Rapid Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Innovative Technologies for Salvage Procedures of Failed Treatments of Osteoarthritis: Biomimetics Solutions (CustomPN)
Status: NOT_YET_RECRUITING
Conditions: Bone Loss|Hip Prosthesis Infection|Arthroplasty Complications
Interventions: DEVICE: custom-made acetabular implant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment Results After Acute Rupture of the Achilles Tendon.
Status: COMPLETED
Conditions: Rupture of Achilles Tendon
Interventions: PROCEDURE: Non-operative treatment|PROCEDURE: Open surgery|PROCEDURE: Mini-invasive surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Tibolone Versus Transdermal E2/NETA on Sexual Function in Naturally Postmenopausal Women (P06089)
Status: COMPLETED
Conditions: Sexual Dysfunction
Interventions: DRUG: tibolone|DRUG: estradiol-norethisterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Early Interventions on Neurocognitive Profile of Children With Autism Spectrum Disorder
Status: TERMINATED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Early Start Denver Model|BEHAVIORAL: 'as-usual' intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aurinia Renal Assessments 2: Aurinia Renal Response in Lupus With Voclosporin
Status: COMPLETED
Conditions: Lupus Nephritis
Interventions: DRUG: Voclosporin|DRUG: Placebo Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Vaginal Estrogen for Postpartum Obstetric Anal Sphincter Injury Recovery
Status: RECRUITING
Conditions: Obstetric; Injury Pelvic Floor|Sexual Dysfunction|Anal Incontinence|Urinary Incontinence
Interventions: DRUG: Estradiol 0.01% Vag Cream|DRUG: Placebo vaginal cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Udenafil to Treat Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: DA-8159 (Udenafil)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3473329 in Participants With Impaired and Normal Renal Function
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Insufficiency
Interventions: DRUG: LY3473329
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Use of the 25 (OH) D Saliva Test as a Substitute for the 25 (OH) D Serum Test in Healthy People
Status: COMPLETED
Conditions: Nutritional Deficiency
Interventions: DIAGNOSTIC_TEST: not currently consumed vitamin D supplements regularly|DIAGNOSTIC_TEST: consumed vitamin D supplements regularly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: GastroBot: Artificial Intelligence Applied to Bowel Preparation
Status: NOT_YET_RECRUITING
Conditions: Colonic Polyp|Colonic Neoplasms|Colonic Disease|Colonic Adenoma
Interventions: DEVICE: GastroBot|OTHER: Conventional explanation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Prolonged Exposure (PE) for Post Traumatic Stress Disorder (PTSD): Telemedicine Versus In Person
Status: COMPLETED
Conditions: PTSD
Interventions: BEHAVIORAL: Telemedicine|BEHAVIORAL: In Person
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Iron Depletion by Phlebotomy Plus Lifestyle Changes vs. Lifestyle Changes Alone on Liver Damage in Patients With Nonalcoholic Fatty Liver Disease With Increased Iron Stores
Status: UNKNOWN
Conditions: Nonalcoholic Fatty Liver Disease
Interventions: OTHER: Iron depletion treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Secondary Prophylaxis After Variceal Bleeding in Non-Responders
Status: COMPLETED
Conditions: Gastrointestinal Hemorrhage|Portal Hypertension|Cirrhosis
Interventions: PROCEDURE: esofagic varices ligation|DRUG: Nadolol|DRUG: Isosorbide mononitrate|DRUG: Prazosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Post-Stroke Aphasia and Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment Study
Status: COMPLETED
Conditions: Aphasia|Stroke
Interventions: DEVICE: Magstim SuperRapid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vorinostat in Combination With Azacitidine in Patients With Newly-Diagnosed Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndrome (MDS)
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Vorinostat|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diaphragmatic Breathing as an Adjunctive Therapy in the Management of Children With Bladder and Bowel Disorders
Status: COMPLETED
Conditions: Bladder and Bowel Disorder, Pediatric
Interventions: BEHAVIORAL: Diaphragmatic Breathing|BEHAVIORAL: Standard Urotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-Centre, Randomised, Controlled, Masked Phase 2 Study of the Safety and Efficacy of KIO-101 Ophthalmic Solution, Versus Vehicle Control in the Treatment of Dry Eye Disease in Patients With Autoimmune Disease
Status: TERMINATED
Conditions: Dry Eye Disease
Interventions: DRUG: KIO-101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of 12-week SOF/VEL Regimen Combined With Prophylactic Use of TAF for Treatment-naïve Genotype 1-6 HCV/HBV Co-infection Adult Patients With or Without Compensated Cirrhosis in China
Status: UNKNOWN
Conditions: Chronic Hepatitis C|Chronic Hepatitis B
Interventions: DRUG: Tenofovir Alafenamide 25 MG|DRUG: Sofosbuvir / Velpatasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief Intervention by Community Health Workers for Unhealthy Drinking in Latinos
Status: COMPLETED
Conditions: Drinking Heavy|Drinking Behavior|Drinking Excessive
Interventions: BEHAVIORAL: Motivational Enhancement Therapy and Strengths Based Case Management (MET/SBCM)|OTHER: Alcohol education brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation and Gamified Rehabilitation for Upper Limb Function in Pediatric Brain Damage
Status: NOT_YET_RECRUITING
Conditions: Paediatric Brain Damage|Cerebral Palsy|Paediatric Stroke|Paediatric Traumatic Brain Injury|Paediatric Acquired Brain Injury
Interventions: DEVICE: Active Transcranial Direct Current Stimulation|DEVICE: Sham Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: KW-0761 or Investigator's Choice in Subjects With Previously Treated Adult T-cell Leukemia-Lymphoma (ATL)
Status: COMPLETED
Conditions: Adult T-cell Leukemia-Lymphoma
Interventions: BIOLOGICAL: KW-0761|DRUG: Pralatrexate|DRUG: gemcitabine plus oxaliplatin|DRUG: DHAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypocaloric vs. Full Energy Enteral Feeding in Critically Ill Patients
Status: UNKNOWN
Conditions: Enteral Feeding
Interventions: OTHER: Hypocaloric feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High- Versus Low-calcium Water for Bone Health
Status: RECRUITING
Conditions: Orthopedic Disorder|Calcium Metabolism Disorders|Bone Resorption|Water-Electrolyte Imbalance|Eating, Healthy
Interventions: OTHER: Loading of low-calcium water first, then high-calcium water
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: TRAIN-BW: Backward Walking Training in Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis|Gait Disorders, Neurologic|Accidental Fall
Interventions: BEHAVIORAL: Backward Walking Training|BEHAVIORAL: Forward Walking Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study on the Efficacy of Agomelatine Combined With Antipsychotics to Treat Negative Symptoms in Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia|Negative Symptoms in Schizophrenia
Interventions: DRUG: Agomelatine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT Comparing Conventional Haemorrhoidectomy With Laser Haemorrhoidoplasty
Status: RECRUITING
Conditions: Hemorrhoids
Interventions: COMBINATION_PRODUCT: Laser Haemorrhoidoplasty (LAH)|PROCEDURE: Open milligan-morgan conventional haemorrhoidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy
Status: TERMINATED
Conditions: Lung Cancer|Pulmonary Complications|Radiation Fibrosis
Interventions: DRUG: captopril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Non-operative Treatment of Acute Achilles Tendon Rupture: Early Controlled Mobilization Compared With Immobilization
Status: COMPLETED
Conditions: Achilles Tendon Rupture|Deep Vein Thrombosis
Interventions: PROCEDURE: Controlled early mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-Based Stress Reduction (MBSR) and Transcranial Direct Current Stimulation (tDCS)
Status: COMPLETED
Conditions: Anxiety Disorders|Mood Disorders|Transcranial Direct Current Stimulation|tDCS|Stress Reduction
Interventions: DEVICE: Active tDCS|OTHER: sham tDCS|BEHAVIORAL: MBSR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Docetaxol Plus Cisplatin Versus 5-Fu Plus Cisplatin as 1st-line Chemotherapy in Advanced ESCC Patients
Status: UNKNOWN
Conditions: Esophagus Cancer|Chemotherapy Effects
Interventions: DRUG: Docetaxel|DRUG: Fluorouracil|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palliative Pancreatic Duct Stenting in Patients With Inoperable Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer|Pancreatic Duct Stricture
Interventions: PROCEDURE: ERCP|DEVICE: Covered Self-expandable Metal Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: INCB039110 in Combination With Dabrafenib and Trametinib in Patients With BRAF-mutant Melanoma and Other Solid Tumors.
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: Trametinib|DRUG: Dabrafenib|DRUG: INCB039110
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sulforaphane to Reduce Symptoms of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Sulforaphane Nutraceutical|DRUG: Identical-appearing Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Increased Lactic Acid and Abnormal Fat Distribution in HIV-Positive Patients
Status: COMPLETED
Conditions: HIV Infections|Lipodystrophy
Interventions: DRUG: Lamivudine/Zidovudine|DRUG: Abacavir sulfate|DRUG: Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Tampa Associating Microwave Liver Ablation With Portal Vein Ligation for Staged Hepatectomy (TAMLAPS)
Status: ENROLLING_BY_INVITATION
Conditions: Liver Cancer|Liver Tumor|Hepatocellular Carcinoma|Hilar Cholangiocarcinoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Patient Education Bundle vs. Nurses Feedback and Coaching to Prevent Missed Doses of VTE Prophylaxis
Status: COMPLETED
Conditions: Venous Thrombosis (Disorder)
Interventions: BEHAVIORAL: Patient education bundle (PEB),|BEHAVIORAL: Nurse feedback and coaching (NFC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Open Label Study to Assess the Predictability of Early Response to Certolizumab Pegol in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Certolizumab pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Trial Of Oral PF-00299804 By Continuous Dosing In Patients With Recurrent Or Metastatic Head And Neck Squamous Cell Cancer
Status: COMPLETED
Conditions: Head and Neck Neoplasms
Interventions: DRUG: PF-00299804
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficiency of a Guiding Device for Inferior Alveolar Nerve Block, EZ-Block®, Compared to a Conventional Freehand Administration.
Status: RECRUITING
Conditions: Tooth Avulsion
Interventions: PROCEDURE: Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: CMAP Plus Trauma-focused Cognitive Behavior Therapy for Suicidal Ideation Among Burn Survivors
Status: NOT_YET_RECRUITING
Conditions: Suicidal Ideation|Trauma, Psychological
Interventions: BEHAVIORAL: CMAP Plus TFCBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outcome of TKA Using Customized Cutting Block Compared With Conventional Intramedullary Cutting Guide
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Patient specific cutting guides|PROCEDURE: Standard knee cutting guides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BOW015 (Infliximab-EPIRUS) and Infliximab in Patients With Active Rheumatoid Arthritis: The UNIFORM Study
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: BOW015|DRUG: Remicade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effects of Acid Reducing Agents on Pharmacokinetics of PC14586 in Healthy Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: PC14586|DRUG: Rabeprazole|DRUG: Famotidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Helmet Continuous Positive Airway Pressure Versus Oxygen Venturi in Acute Respiratory Failure in CAP: CAPOVeRSO
Status: TERMINATED
Conditions: Pneumonia|Community-Acquired Infections|Respiratory Insufficiency|Acute Lung Injury
Interventions: PROCEDURE: Castar Starmed (CPAP) delivered by a helmet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose, Safety and Pathogenicity of SARS-CoV-2 Omicron Virus (BA.5)
Status: NOT_YET_RECRUITING
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: SARS-CoV-2 omicron virus dose arm 1|BIOLOGICAL: SARS-CoV-2 omicron virus dose arm 2|BIOLOGICAL: SARS-CoV-2 omicron virus dose arm 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Strength Training in Hypoxia to Improve Bone and Cardiovascular Health of Elderly
Status: COMPLETED
Conditions: Aging Well
Interventions: BEHAVIORAL: Passive Hypoxia|BEHAVIORAL: Normoxia Circuit Training with Elastic Bands|BEHAVIORAL: Hypoxia Circuit Training with Elastic Bands|BEHAVIORAL: Normoxia Vibration|BEHAVIORAL: Hypoxia Vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Biatain Ag vs Biatain in the Treament of Leg Ulcers
Status: COMPLETED
Conditions: Leg Ulcers
Interventions: DEVICE: Biatain Ag|DEVICE: Biatain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intra-articular Lopain (MTX-071) Phase I/IIa Study in Chronic Osteoarthritic Knee Joint Pain
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Lopain
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study in Metastatic Cancer and Advanced or Metastatic Unresectable Pancreatic Cancer
Status: COMPLETED
Conditions: Neoplasms|Neoplasm Metastasis|Pancreatic Cancer
Interventions: DRUG: Galunisertib|DRUG: Gemcitabine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Veno-venous Hemodialysis and Continuous Veno-venous Hemodiafiltration on Urea Reduction Rate in Intensive Care Patient
Status: NOT_YET_RECRUITING
Conditions: Acute Kidney Injury|Continuous Renal Replacement Therapy|Intensive Care Unit
Interventions: OTHER: CVVHD Dialysis parameters|OTHER: CVVHDF Dialysis parameters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Brain Neurotransmitter Levels in Adults With ADHD, Before and After Stimulant Treatment
Status: TERMINATED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: OTHER: Neurotransmitters evaluation by MRS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 3 Study of KHK7580 for the Treatment of Hypercalcemia in Patients With Parathyroid Carcinoma or Primary Hyperparathyroidism
Status: COMPLETED
Conditions: Parathyroid Carcinoma|Primary Hyperparathyroidism
Interventions: DRUG: KHK7580
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Indocyanine Green During Primary Repair of Oesophageal Atresia and Distal Tracheo-oesophageal Fistula
Status: NOT_YET_RECRUITING
Conditions: Tracheo-Esophageal Fistula With Atresia of Esophagus
Interventions: DRUG: Indocyanine green
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: FLudrocortisone Administration in Aneurysmal Subarachnoid Haemorrhage
Status: NOT_YET_RECRUITING
Conditions: Aneurysmal Subarachnoid Hemorrhage
Interventions: DRUG: Fludrocortisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sequent Please Drug Coated Balloons Versus Primary Stent Application in Long SFA Lesions
Status: COMPLETED
Conditions: Stenosis|Occlusion|Restenosis
Interventions: DEVICE: SeQuent Please OTW|DEVICE: Eluvia Vascular Stent System|DEVICE: Nitinol stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of VG161 in Subjects With Advanced Primary Liver Cancer
Status: UNKNOWN
Conditions: Primary Liver Cancer
Interventions: DRUG: Recombinant Human IL12/15-PDL1B Oncolytic HSV-1 Injection (Vero Cell))
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: iMEA : Comparison of Micro-innervation and Muscle Microstructure of the Anal Levator Muscle Between Patients With Urogenital Prolapse and Those Who Are Asymptomatic
Status: RECRUITING
Conditions: Prolapse Genital
Interventions: OTHER: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: VEGF Trap-Eye in Choroidal Neovascularization Secondary to Pathologic Myopia (mCNV)
Status: COMPLETED
Conditions: Myopia, Pathological
Interventions: BIOLOGICAL: VEGF Trap-Eye (BAY86-5321)|PROCEDURE: No Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pitolisant in Patients With Prader-Willi Syndrome
Status: RECRUITING
Conditions: Prader-Willi Syndrome
Interventions: DRUG: Pitolisant tablet|OTHER: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neural Correlates of Stress Hormones
Status: COMPLETED
Conditions: Borderline Personality Disorder|PTSD
Interventions: DRUG: Hydrocortisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Tolerability Study for T-1101 (Tosylate) to Treat Advanced Refractory Solid Tumors
Status: TERMINATED
Conditions: Advanced Refractory Solid Tumors
Interventions: DRUG: T-1101 (Tosylate)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept Study of RHB-104 as Add-On Therapy to Interferon Beta-1a in Relapsing Remitting Multiple Sclerosis (RRMS)
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: RHB-104
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Denosumab and Screw Fixation for Osteoporotic Compression Fracture
Status: WITHDRAWN
Conditions: Denosumab Allergy
Interventions: DRUG: Denosumab Only Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Intravenous Progesterone in Patients With Severe Traumatic Brain Injury
Status: COMPLETED
Conditions: Brain Injuries
Interventions: DRUG: Progesterone|DRUG: Lipid emulsion without progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Etoposide-carboplatin in Combination With Pembrolizumab and Lenvatinib Maintenance in HG-NETs
Status: NOT_YET_RECRUITING
Conditions: Neuroendocrine Tumors
Interventions: COMBINATION_PRODUCT: Pembrolizumab in combination with carboplatin and etoposide chemotherapy followed by pembrolizumab and lenvatinib maintenance therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Sotatercept in Adults With Transfusion Dependent Diamond Blackfan Anemia
Status: TERMINATED
Conditions: Diamond Blackfan Anemia
Interventions: DRUG: Sotatercept|DRUG: Sotatercept with prednisone boost
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Paclitaxel, Carboplatin and Temozolomide
Status: COMPLETED
Conditions: Lung Diseases|Cancer
Interventions: DRUG: Combination Treatment - Cohort 1|DRUG: Combination Treatment - Cohort 2|DRUG: Combination Treatment - Cohort 3|DRUG: Combination Treatment - Cohort 4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Effects of Sacral Neuromodulation
Status: COMPLETED
Conditions: Urinary Tract Disease
Interventions: RADIATION: Baseline neuroimaging|RADIATION: Neuroimaging during sacral neuromodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Efficacy and Safety of Azeliragon (TTP488) in Patients With Mild Alzheimer's Disease
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: Azeliragon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intense Therapeutic Ultrasound (ITU) to Treat Plantar Fasciitis
Status: UNKNOWN
Conditions: Plantar Fasciitis|Plantar Fasciitis, Chronic|Ultrasound Therapy
Interventions: DEVICE: Intense Therapeutic Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home-Based Exercise Training in Older Adults During the COVID-19 Pandemic
Status: COMPLETED
Conditions: Physical Inactivity|Aging|COVID-19 Pandemic
Interventions: OTHER: Supervised Home Based Exercise Training|OTHER: Unsupervised stretching and breathing exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Association Between Skeletal Muscle Mass and Severity of Polycystic Liver Disease and Polycystic Kidney Disease
Status: UNKNOWN
Conditions: Polycystic Kidney Diseases|Polycystic Liver Disease|Muscle Loss
Interventions: PROCEDURE: Renal artery embolization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial Comparing Three Anterior Cruciate Ligament Reconstructive Procedures
Status: COMPLETED
Conditions: Knee Injuries
Interventions: PROCEDURE: Single bundle hamstring|PROCEDURE: Double bundle hamstring|PROCEDURE: Bone patellar tendon bone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Metronomic Capecitabine and Oxaliplatin Versus XELOX in Egyptian Metastatic Colorectal Cancer Patients
Status: COMPLETED
Conditions: Clinical Response|Toxicity|Survival
Interventions: DRUG: metronomic XELOX|DRUG: Classic XELOX|OTHER: Blood samples for pharmacological studies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Adapted Safe Childbirth Checklist in Chiapas, Mexico
Status: COMPLETED
Conditions: Pregnancy|Childbirth|Quality of Care|Puerperium
Interventions: BEHAVIORAL: Adapted Safe Childbirth Checklist
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety Study of Seroquel SR in the Treatment of Generalised Anxiety Disorder
Status: COMPLETED
Conditions: Anxiety Disorders
Interventions: DRUG: Quetiapine XR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protocol Based Selective Imaging Versus Routine Computed Tomography or Ultrasound in Suspected Appendicitis
Status: RECRUITING
Conditions: Appendicitis
Interventions: DIAGNOSTIC_TEST: Abdominal imaging|OTHER: Score based selective abdominal imaging|OTHER: Score based selective observation combined with selective abdominal imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Beta-Agonist Versus OnabotulinumtoxinA Trial for Urgency Urinary Incontinence
Status: RECRUITING
Conditions: Urgency Urinary Incontinence
Interventions: DRUG: Beta3-Agonists, Adrenergic [Mirabegron/Vibegron]|DRUG: OnabotulinumtoxinA 100 UNT [Botox]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety on Blood Pressure In Patients With Hypertension Diagnosed Congestive Heart Failure
Status: COMPLETED
Conditions: Hypertension|Congestive Heart Failure
Interventions: DRUG: Candemore tablet|DRUG: Atacand tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apremilast for Chronic Plaque Psoriasis (CPP) Patients Who Have Failed One Course of Biologic Therapy
Status: WITHDRAWN
Conditions: Chronic Plaque Psoriasis
Interventions: DRUG: apremilast
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Phenoptin in Subjects With Hyperphenylalaninemia Due to BH4 Deficiency
Status: COMPLETED
Conditions: Tetrahydrobiopterin Deficiencies|Hyperphenylalaninemia, Non-Phenylketonuric
Interventions: DRUG: Phenoptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Endostar Combined With Chemotherapy and Immunotherapy in Lung Squamous Cell Carcinom
Status: RECRUITING
Conditions: Lung Squamous Cell Carcinoma
Interventions: DRUG: To explore the efficacy and safety of immune checkpoint inhibitor combined with endostar and chemotherapy in the treatment of advanced lung squamous cell carcinoma (stage IIIB-IV).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid Maxillary Expansion for Residual Pediatric
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: PROCEDURE: Standard clinical practice|DEVICE: Standard clinical practice + Rapid Maxillary Expansion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Gut Peptides on Bone Remodeling
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Glucagon-Like Peptide-2 (GLP-2)|OTHER: Glucose-dependent insulinotropic polypeptide (GIP)|OTHER: GLP-2+GIP|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Yoga, Survivorship Health Education, and Cognitive Behavioral Therapy in Reducing Insomnia in Cancer Survivors
Status: COMPLETED
Conditions: Cancer Survivor|Insomnia|Malignant Neoplasm
Interventions: BEHAVIORAL: Behavioral Intervention|OTHER: Cognitive Intervention|OTHER: Educational Intervention|OTHER: Laboratory Biomarker Analysis|DEVICE: Monitoring Device|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Efficacy and Safety Study of Theraflu Night Powder as Oral Solution for Cold and Flu
Status: WITHDRAWN
Conditions: Infections, Respiratory Tract
Interventions: DRUG: Paracetamol, phenylephrine HCl, pheniramine maleate, and vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GAG-therapy Efficacy Trial Solution for Bladder Pain Syndrome/ Interstitial Cystitis (GETSBI Study)
Status: RECRUITING
Conditions: Bladder Pain Syndrome
Interventions: DEVICE: IALURIL Prefill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study Of GSK1358820 In Patients With Post-Stroke Upper Limb Spasticity
Status: COMPLETED
Conditions: Post-Stroke Spasticity|Cerebrovascular Accident
Interventions: DRUG: GSK1358820|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Reparel Knee Sleeve With Knee Injection
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Reparel knee sleeve|DRUG: Corticosteroid injection|DEVICE: Placebo knee sleeve
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Smoking, Benzodiazepine (BZD) Use and Obesity on Severe Obstructive Sleep Apnea (sOSA)
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Obesity|Smoking
Interventions: OTHER: Smoking|OTHER: Obesity|OTHER: Benzodiazepine use
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Single Dose-escalation Study to Evaluate the Safety and Pharmacokinetics of RBD1016
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: RBD1016|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pregnancy Outcomes in Women With Unexplained Recurrent Pregnancy Loss Treated With Low Dose Aspirin and Unfractionated Heparin
Status: UNKNOWN
Conditions: Recurrent Pregnancy Loss
Interventions: DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Phase I Trial of a Novel Synthetic Polymer Nerve Conduit 'Polynerve' in Participants With Sensory Digital Nerve Injury
Status: COMPLETED
Conditions: Injury of Nerves at Wrist and Hand Level
Interventions: DEVICE: Polynerve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HAIC Combined With Camrelizumab and TKI for Unresectable Hepatocellular Carcinoma After TACE Failure
Status: RECRUITING
Conditions: Unresectable Hepatocellular Carcinoma
Interventions: DRUG: Camrelizumab|DRUG: HAIC|DRUG: TKI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pelvic Fractures in Polytraumatized Patients With Hemodynamic Instability: Angioembolization vs Preperitoneal Packing
Status: WITHDRAWN
Conditions: Trauma|Pelvic Fracture|Hemodynamic Instability
Interventions: PROCEDURE: Angioembolization|PROCEDURE: Preperitoneal Pelvic Packing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption in GBM Patients
Status: UNKNOWN
Conditions: Glioma, Malignant|Glioblastoma
Interventions: DEVICE: Magnetic Resonance guided Focused ultrasound (MRgFUS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase II Combination Stem Cell Therapy for the Treatment of Severe Coronary Ischemia(CI)
Status: SUSPENDED
Conditions: Heart Disease|Blocked Arteries|Coronary Ischemia|Coronary Disease|Coronary Artery Disease|Coronary Atherosclerosis
Interventions: BIOLOGICAL: MESENDO|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sense to Act: An Interoceptive Sensibility Intervention for Musculoskeletal Pain
Status: RECRUITING
Conditions: Musculoskeletal Pain|Chronic Pain
Interventions: BEHAVIORAL: Interoception-based intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Radiation Therapy and Peripheral Stem Cell Transplant in Treating Children With Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: BIOLOGICAL: bleomycin sulfate|DRUG: chlorambucil|DRUG: cisplatin|DRUG: dacarbazine|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: melphalan|DRUG: prednisolone|DRUG: procarbazine hydrochloride|DRUG: vinblastine sulfate|DRUG: vincristine sulfate|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: FST-100 in the Treatment of Acute Adenoviral Conjunctivitis
Status: COMPLETED
Conditions: Acute Adenoviral Conjunctivitis
Interventions: DRUG: FST-100|DRUG: FST-100 (Component #1)|DRUG: FST-100 Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I- Sequential Cohort Dosing to Determine Maximum Tolerated Dose in Healthy Male Volunteers.
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: NW-3509a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Selumetinib and Cyclosporine in Treating Patients With Advanced Solid Tumors or Advanced or Metastatic Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Colorectal Carcinoma|Solid Neoplasm|Stage IIIA Colorectal Cancer AJCC v7|Stage IIIB Colorectal Cancer AJCC v7|Stage IIIC Colorectal Cancer AJCC v7|Stage IVA Colorectal Cancer AJCC v7|Stage IVB Colorectal Cancer AJCC v7
Interventions: DRUG: Cyclosporine|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Selumetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Risk Factor Intervention Trial in Breast Cancer Survivors
Status: NOT_YET_RECRUITING
Conditions: Metabolic Disturbance|Sedentary Behavior|Breast Cancer Female
Interventions: BEHAVIORAL: Guidelines-based healthy eating|BEHAVIORAL: Guidelines-based physical activity|BEHAVIORAL: Stretching exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Restrictive Versus Liberal Rate of Extracorporeal Volume Removal Evaluation in Acute Kidney Injury
Status: COMPLETED
Conditions: Acute Kidney Injury|Fluid Overload|Hypotension|Dialysis; Complications|Critical Illness
Interventions: PROCEDURE: Restrictive UFnet Rate Strategy|PROCEDURE: Liberal UFnet Rate Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of Brolucizumab 6 mg Dosed Every 4 Weeks Compared to Aflibercept 2 mg Dosed Every 4 Weeks in Patients With Retinal Fluid Despite Frequent Anti-VEGF Injections
Status: TERMINATED
Conditions: Age-Related Macular Degeneration
Interventions: BIOLOGICAL: Brolucizumab|BIOLOGICAL: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Astrocytoma / Desmoplastic Gamliogliomes (DIA / DIG) - Study of the French Cohort of the Last 20 Years : Clinical, Anatomopathological, Molecular and Radiological Charactersics
Status: UNKNOWN
Conditions: Astrocytoma|Ganglioglioma Desmoplastics and Infantile
Interventions: OTHER: To study the characteristics of patients with DIA / DIG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Role of Eicosanoids in the Cardiovascular Actions of Inhaled Nanoparticles
Status: COMPLETED
Conditions: Blood Biomarkers|Vasodilation|Blood Clotting|Lung Function|Healthy Volunteers
Interventions: OTHER: diesel exhaust particulate|OTHER: carbon nanoparticles|OTHER: small graphene oxide|OTHER: ultrasmall graphene oxide|OTHER: filtered air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of CA-008 (Vocacapsaicin) in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Postsurgical Pain
Interventions: DRUG: CA-008|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TElemedicine to Replace Face-to-face Physician Consultation in Patients With HyperTension : a Pilot Randomized-controlled Trial
Status: COMPLETED
Conditions: Hypertension
Interventions: DEVICE: telemedicine|OTHER: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study About the Validity of MRS-guided Resection on Prognosis High-grade Glioma Gliomas
Status: UNKNOWN
Conditions: Glioma|Anaplastic Oligoastrocytoma|Glioblastomas (GBM)
Interventions: PROCEDURE: Structural Image Guidance|PROCEDURE: Metabolic Image Guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Will Assess the Safety, Neutralizing Activity and Efficacy of AZD3152 in Adults With Conditions Increasing Risk of Inadequate Protective Immune Response After Vaccination and Thus Are at High Risk of Developing Severe COVID-19
Status: COMPLETED
Conditions: COVID-19, SARS-CoV-2
Interventions: BIOLOGICAL: Biological: AZD3152|BIOLOGICAL: Biological: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ShuntCheck Versus Radionuclide in Evaluating Shunt Function in Symptomatic NPH Patients
Status: COMPLETED
Conditions: Hydrocephalus
Interventions: DEVICE: ShuntCheck test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Nivolumab + Cabiralizumab + Gemcitabine in Patients With Stage IV Pancreatic Cancer Achieving Disease Control in Response to First-line Chemotherapy (GemCaN Trial).
Status: SUSPENDED
Conditions: Pancreatic Cancer Stage IV
Interventions: DRUG: Gemcitabine|DRUG: Nivolumab 10 MG/ML Intravenous Solution [OPDIVO]|DRUG: Cabiralizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Prognosis Effect of Indocyanine Green (ICG) Fluorescence Guided Surgery on Disease-free Survival (DFS) of Stage III Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer Stage III
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Phase 2 Trial of Axitinib and TRC105 Versus Axitinib Alone in Patients Renal Cell Carcinoma
Status: TERMINATED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: TRC105 and Axitinib|DRUG: Axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT