pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Bioequivalence Study of Sitagliptin Hydrochloride / Metformin Hydrochloride Extended-release Film Coated Tablets 100 mg /1000 mg (FDC) in Healthy Adult Male and Female Subjects Under Fed Conditions.
Status: COMPLETED
Conditions: Bioequivalence|Diabetes Mellitus, Type 2
Interventions: DRUG: Sitagliptin/Metformin HCl 100/1000 mg extended release film-coated tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Trial of Sunitinib in Patients With Type B3 Thymoma or Thymic Carcinoma in Second and Further Lines (Style Trial)
Status: UNKNOWN
Conditions: Type B3 Thymoma|Thymic Carcinoma
Interventions: DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Confirming Proper Replacement of Dislodged Gastrostomy Tubes in Pediatric Patients
Status: COMPLETED
Conditions: Gastrostomy Tube Site Complication|Gastrostomy Complications
Interventions: DIAGNOSTIC_TEST: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Asacol 4.8 g/Day Versus Asacol 2.4 g/Day (ASCEND I)
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: mesalamine|DRUG: mesalamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Serum Measurements of Molecular Biomarkers and Serum Protein Profiling Can be Used to Predict Which Patients Undergoing Prostatic Biopsy Will be Diagnosed With Cancer
Status: TERMINATED
Conditions: Prostate Cancer|Elevated Prostate Specific Antigen (PSA)
Interventions: OTHER: serum specimens obtained will be utilized for proteomic profiling comprising MALDI-TOF MS, and serum biomarker assays.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: S-Frame CT Immobilization Masks For Patients Undergoing Radiation Therapy For Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Neoplasms
Interventions: DEVICE: MedTec S-frame Immobilization Masks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-dose Chidamide Maintenance Therapy After Allo-HSCT for T-cell Acute Lymphoblastic Leukemia or T-cell Lymphomas
Status: RECRUITING
Conditions: T Lymphoblastic Leukemia/Lymphoma
Interventions: DRUG: Chidamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Atrioventricular Nodal Reentrant Tachycardia Ablation With Irrigated Catheter and Three-dimensional Electroanatomic Mapping
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrioventricular Nodal Re Entrant Tachycardia
Interventions: PROCEDURE: Transcatheter ablation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectivenes of Erector Spinae Plane Block in Percutaneous Nephrolithotomy?
Status: UNKNOWN
Conditions: Postoperative Pain|Nephrolithotomy, Percutaneous|Erector Spinae Plane Block
Interventions: PROCEDURE: erector spinae block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Immunogenicity and Safety of VARIVAX® Passage Extension 34 (PE34) Process in Children (V210-A03)
Status: COMPLETED
Conditions: Varicella
Interventions: BIOLOGICAL: VARIVAX® PE34 Process|BIOLOGICAL: VARIVAX® 2016 Commercial Process|BIOLOGICAL: M-M-R II®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Investigation Of Two Different İnterventions İn Hemiplegic Patients
Status: COMPLETED
Conditions: Stroke|Physiotherapy and Rehabilitation
Interventions: OTHER: Bobath Exercises|OTHER: Breathing Exercises,Breathing Exercises, Bobath Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Microdose Study of TTX-MC138-NODAGA-Cu64 in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumor
Interventions: DRUG: TTX-MC138-NODAGA-Cu64
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Identification of Fecal Microbiota Biomarkers of Spondyloarthritis in Patients Suffering From Crohn's Disease.
Status: RECRUITING
Conditions: Crohn Disease|Spondyloarthritis
Interventions: OTHER: Microbiota Sequencing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Interscalene and Combined Supra Scapular and Axillary Nerve Blocks in Rotator Cuff Repair
Status: COMPLETED
Conditions: Disorder of Rotator Cuff
Interventions: PROCEDURE: interscalene block|PROCEDURE: Suprascapular and Axillary nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigate Role of Metabolic Imaging in Predicting Tumor Response/Outcome After Pancreatic CA Tx
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: PROCEDURE: PET Scan|DRUG: FLT|DRUG: FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Telephone Education on Fear of Movement and Quality of Life in Patients With Lumbar Disc Herniation Surgery.
Status: RECRUITING
Conditions: Spine Disease|Spinal Deformity
Interventions: BEHAVIORAL: post-discharge rehabilitation training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trametinib in Combination With Sorafenib in Patients With Advanced Hepatocellular Cancer
Status: COMPLETED
Conditions: Hepatocellular Cancer|Liver Cancer
Interventions: DRUG: Trametinib|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste
Status: COMPLETED
Conditions: Dental Plaque|Gingivitis
Interventions: DRUG: Colgate Cavity Protection toothpaste|DRUG: Colgate Total toothpaste|DRUG: Parodontax toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of Bevacizumab Scheduling With Chemotherapy for Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Bevacizumab|DRUG: Oxaliplatin|DRUG: levo-folinic acid|DRUG: 5-fluorouracil|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Global Postural Reeducation Versus Neck Stabilization Training on Text Neck Syndrome.
Status: COMPLETED
Conditions: Neck Syndrome
Interventions: OTHER: global postural reeducation|OTHER: neck stabilization training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Blood PREssure Augmentation in Large-vessel Occlusion Stroke Study
Status: ENROLLING_BY_INVITATION
Conditions: Ischemic Stroke|Blood Pressure
Interventions: DRUG: Phenylephrine|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing School Based Interventions for Adolescents With Attention Deficit Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: BEHAVIORAL: Challenging Horizons Program (CHP) after-school model|BEHAVIORAL: Challenging Horizons Program (CHP) consultation model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Strategy of Primary PCI for Left Main Coronary Artery Occlusion Induced AMI
Status: UNKNOWN
Conditions: Acute Myocardial Infarction|Percutaneous Coronary Intervention
Interventions: DEVICE: Deferred stent implantation|DEVICE: Immediate stent implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide (Revlimid®, CC-5013) in Subjects With Relapsed or Refractory Indolent Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkins Lymphoma
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 28 Day Parallel Group Study to Assess the Effects of RDN-929
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: RDN-929 oral capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: GSK159802 In Healthy Male Subjects And Asthmatics
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK159802|DRUG: Placebo|DRUG: Salmeterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: Rasagiline 1 mg and 2 mg Added to Aricept 10 mg Daily in Patients With Mild to Moderate Alzheimer's Disease (AD)
Status: COMPLETED
Conditions: Dementia|Alzheimer's Disease
Interventions: DRUG: Rasagiline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tipping Point: Using Social Network Theory to Accelerate Scale and Impact
Status: ACTIVE_NOT_RECRUITING
Conditions: Contraception
Interventions: BEHAVIORAL: Household Visits|BEHAVIORAL: Small Groups|BEHAVIORAL: Adopt-a-Friend
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Combinations of Paracetamol, Ibuprofen, and Dexamethasone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty
Status: COMPLETED
Conditions: Pain, Acute|Hip Arthropathy|Analgesia|Postoperative Pain
Interventions: DRUG: Paracetamol|DRUG: Ibuprofen|DRUG: Dexamethasone|DRUG: Placebo oral capsules|DRUG: Placebo IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-level Laser Therapy on Inflammatory Mediators During Chemotherapy-induced Oral Mucositis
Status: COMPLETED
Conditions: Oral Mucositis
Interventions: RADIATION: Low-Level laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tripe Versus Dual Antiretroviral Therapy in HIV-infected Patients With Virological Suppression (Tridual)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Continue with triple therapy|DRUG: Switch to DTG + 3TC|DRUG: Switch to DRV/cobicistat + 3TC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vibrational Spectroscopy for Endometrial Cancer Diagnosis
Status: RECRUITING
Conditions: Endometrial Cancer|Endometrial Hyperplasia
Interventions: BEHAVIORAL: Information about clinical risk factors for endometrial cancer and endometrial hyperplasia|PROCEDURE: Blood and endometrial tissue sampling|PROCEDURE: Lymph node sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exemestane With Celecoxib as Neoadjuvant Treatment in Postmenopausal Women With Stage II, III, and IV Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Exemestane|DRUG: Celecoxib|OTHER: Correlative studies
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Infusion of Expanded Cord Blood Cells in Addition to Single Cord Blood Transplant in Treating Patients With Acute Leukemia, Chronic Myeloid Leukemia, or Myelodysplastic Syndromes
Status: RECRUITING
Conditions: Acute Biphenotypic Leukemia|Acute Lymphoblastic Leukemia|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Hematopoietic and Lymphoid Cell Neoplasm|Myelodysplastic Syndrome|Myelodysplastic Syndrome With Excess Blasts
Interventions: BIOLOGICAL: Dilanubicel|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Thiotepa|RADIATION: Total-Body Irradiation|PROCEDURE: Umbilical Cord Blood Transplantation|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspirate|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Multigated Acquisition Scan|PROCEDURE: Electrocardiography|PROCEDURE: Computed Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo Controlled Study of 3 Doses of Rifaximin-EIR Tablet to Treat Moderate, Active Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: Rifaximin-EIR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: KW-3357 Study in Patients With Early Onset Severe Preeclampsia
Status: COMPLETED
Conditions: Preeclampsia
Interventions: DRUG: Antithrombin gamma|DRUG: physiological saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Smartphone App-guided Inspiratory Muscle Strength Training for Lowering Systolic Blood Pressure
Status: NOT_YET_RECRUITING
Conditions: Blood Pressure|Vascular Function|Adherence, Treatment
Interventions: DEVICE: App-Based Inspiratory Muscle Strength Training|DEVICE: Clinic-Based Inspiratory Muscle Strength Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The International Survey of Acute Coronary Syndromes-ARCHIVES
Status: ENROLLING_BY_INVITATION
Conditions: Acute Coronary Syndrome|Unstable Angina Pectoris|Myocardial Infarction|Coronary Disease
Interventions: OTHER: Non-interventional patient registry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bortezomib and Bendamustine to Treat Relapsed/Refractory Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Bendamustine|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT on Necessity of Cholecystectomy for Patients After Clearance of Bile Duct Stones
Status: COMPLETED
Conditions: Gallbladder Stones|Complication|Cholecystectomy
Interventions: OTHER: gallbladder preserved|PROCEDURE: cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial to Compare ReJoinTM to Sodium Hyaluronate Injection for Knee Osteoarthritis Cartilage Defects
Status: UNKNOWN
Conditions: Defect of Articular Cartilage|Knee Osteoarthritis
Interventions: BIOLOGICAL: ReJoinTM|DRUG: Sodium Hyaluronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Chidamide in Combination With Abemaciclib and Endocrinotherapy（Doctor's Choice） in Breast Cancer Patients Previously Treated With Palbociclib
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Chidamide|DRUG: Abemaciclib|DRUG: endocrinotherapy（doctor's choice）
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AMAZE-lung: Amivantamab, Lazertinib and Bevacizumab in Patients With EGFR-mutant Advanced Non-small Cell Lung Cancer With Progression on Previous Third-generation EGFR-TKI
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Amivantamab|DRUG: Lazertinib|DRUG: Zirabev
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Sleep Changes in Inflammatory Bowel Diseases (IBD) Patients.
Status: RECRUITING
Conditions: Disease Bowel|Crohn Disease|Ulcerative Colitis
Interventions: OTHER: Sleep activity|OTHER: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Altitude Sickness Prevention and Efficacy of Comparative Treatments
Status: COMPLETED
Conditions: Acute Mountain Sickness
Interventions: DRUG: Budesonide|DRUG: Acetazolamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Oral PTH(1-34) PK and PD Study in Patients With Hypoparathyroidism
Status: COMPLETED
Conditions: Hypoparathyroidism
Interventions: DRUG: EB612 (EBP05)|DRUG: NATPARA/NATPAR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sensory Restoration After DIEP Flap Neurotization
Status: RECRUITING
Conditions: Breast Cancer|Breast Reconstruction|Sensory Restoration
Interventions: PROCEDURE: DIEP Flap Neurotization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of eFT226 in Subjects With Selected Advanced Solid Tumor Malignancies
Status: RECRUITING
Conditions: Solid Tumor, Adult
Interventions: DRUG: eFT226|DRUG: Sotorasib|DRUG: Fulvestrant|DRUG: Abemaciclib|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Sacrospinous Fixation and V-notes Lateral Suspension Operations
Status: RECRUITING
Conditions: Genital Prolapse, Unspecified
Interventions: DIAGNOSTIC_TEST: pre and post operative POP-Q results|BEHAVIORAL: pre and post operative PİSQ-12 results
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conduction Abnormalities With Severe Aortic Stenosis Before and After Transcatheter Aortic Valve Replacement
Status: COMPLETED
Conditions: Bradycardia
Interventions: DIAGNOSTIC_TEST: Ziopatch Pre discharge|DIAGNOSTIC_TEST: Ziopatch at Discharge|DIAGNOSTIC_TEST: Ziopatch at 2 months
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Intra-articular Fractures of the Mandibular Condyle
Status: RECRUITING
Conditions: Intra-articular Fracture of the Mandibular Condyle
Interventions: PROCEDURE: Open treatment|OTHER: Closed treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study for Capacity Building for a Multi-centre, Randomized Trial for Treatment of Kala Azar in Bangladesh
Status: COMPLETED
Conditions: Visceral Leishmaniasis
Interventions: DRUG: Randomized trial for treatment of kala azar in Bangladesh
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Dasatinib (BMS-354825) and Capecitabine for Women With Advanced Breast Cancer
Status: COMPLETED
Conditions: Advanced Breast Cancer
Interventions: DRUG: Dasatinib|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Imaging in the Diagnosis, Management and Prognosis of Possible Non-convulsive Status Epilepticus
Status: RECRUITING
Conditions: Status Epilepticus|Ictal-interictal Continuum|Positron-emission Tomography|Perfusion Weighted MRI|Perfusion CT
Interventions: DIAGNOSTIC_TEST: MRI scan including arterial spin labelling of the brain|DIAGNOSTIC_TEST: CT perfusion scan of the brain|DIAGNOSTIC_TEST: FDG-PET scan of the brain
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Single Versus Combination Medication Treatment for Children With Attention Deficit Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: Guanfacine|DRUG: Methylphenidate (MPH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Attractive 2 Trial - Pharmacokinetics of ATR-258 Oral Capsule vs. Oral Solution Formulations in Healthy Volunteers
Status: COMPLETED
Conditions: Type2diabetes
Interventions: DRUG: ATR-258 Oral solution|DRUG: ATR-258 Oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Identify Persons Who Are Susceptible to WSP-induced Inflammation and Examine the Role of GSTM1 and Other Factors in This Susceptibility
Status: RECRUITING
Conditions: Airway Inflammation|Allergic Asthma
Interventions: OTHER: Wood Smoke Particles (WSP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: CPI-006 Plus Standard of Care Versus Placebo Plus Standard of Care in Mild to Moderately Symptomatic Hospitalized Covid-19 Patients
Status: TERMINATED
Conditions: Covid-19
Interventions: DRUG: CPI-006 2 mg/kg + SOC|DRUG: CPI-006 1 mg/kg + SOC|DRUG: Placebo + SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of BR1019A and BR1019B Combination Therapy
Status: RECRUITING
Conditions: Essential Hypertension|Type 2 Diabetes Mellitus
Interventions: DRUG: BR1019A|DRUG: BR1019B|DRUG: BR1019C|DRUG: BR1019A-1|DRUG: BR1019B-1|DRUG: BR1019C-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Healthy Options: Group Psychotherapy for HIV-positive Depressed Perinatal Women.
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Task-sharing approach to group therapy|BEHAVIORAL: Enhanced standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study Exploring the Safety and Efficacy of INCAGN01949 in Combination With Immune Therapies in Advanced or Metastatic Malignancies
Status: COMPLETED
Conditions: Advanced Malignancies
Interventions: DRUG: INCAGN01949|DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibuprofen and Opioid (Morphine or Diamorphine) for Acute Pain in Sickle Cell Disease - Sickle With Ibuprofen & Morphine
Status: TERMINATED
Conditions: Sickle Cell Disease
Interventions: DRUG: Ibuprofen|DRUG: Placebo|DRUG: Diamorphine or Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anlotinib and Niraparib Dual Therapy Evaluation in Platinum-resistant Recurrent Ovarian Cancer
Status: UNKNOWN
Conditions: Platinum-resistant Ovarian Cancer
Interventions: DRUG: Niraparib|DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Hope Box - Effectiveness of a Smartphone App for Coping With Suicidal Ideation
Status: COMPLETED
Conditions: Suicidal Ideation|Thoughts of Self Harm|Coping
Interventions: BEHAVIORAL: Virtual Hope Box Smartphone App|BEHAVIORAL: Enhanced Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of TAK-186 (Also Known as MVC-101) in Adults With Advanced or Metastatic Cancer
Status: RECRUITING
Conditions: Squamous Cell Cancer of Head and Neck (SCCHN)|Non-small Cell Lung Cancer (NSCLC)|Colorectal Cancer
Interventions: DRUG: TAK-186
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Horizontal Ridge Augmentation With Demineralized Bone Allograft Layered With Xenograft - a Prospective Clinical Study
Status: RECRUITING
Conditions: Alveolar Ridge Deficiency
Interventions: DEVICE: Xenograft and allograft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Oral Immunonutrition for Patients With Pancreatic Cancer Undergoing Elective Surgery - Effect on Complications and Length of Hospital Stay
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DIETARY_SUPPLEMENT: Oral Impact, Nestlé Health Science
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Individualized Blood Glucose Control in ICU. The CONTROLING Study. A Double Blinded Multicentric Randomized Study.
Status: TERMINATED
Conditions: Critical Illness
Interventions: DRUG: Human insulin - Insulin administration to control blood glucose level.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Osteopathic Manipulative Medicine on the Autonomic Nervous System
Status: COMPLETED
Conditions: Osteopathic Manual Manipulation of Neurovascular Regulation
Interventions: OTHER: Osteopathic Manual Medicine|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Atenativ in Patients With Congenital Antithrombin Deficiency Undergoing Surgery or Delivery
Status: RECRUITING
Conditions: Congenital Antithrombin Deficiency
Interventions: DRUG: Atenativ
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Montelukast on Experimentally-Induced RV16 Infection in Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: montelukast|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Improving Cognition With Neurodegradation Countermeasure
Status: COMPLETED
Conditions: Hemodynamics|Caffeine|TeaCrine|Cognitive Change
Interventions: DIETARY_SUPPLEMENT: TeaCrine and Caffeine|DIETARY_SUPPLEMENT: Caffeine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Pharmacokinetics and the Safety of M518101 in Plaque Psoriasis Patients
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: M518101|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Investigate an Association Between Brain Activity and Tidal Volume in Humans (BATMAN)
Status: RECRUITING
Conditions: Ventilation Therapy; Complications
Interventions: DEVICE: Tidal Volume set on ventilator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Using Immersive Virtual Reality to Treat Pediatric Anxiety
Status: COMPLETED
Conditions: Specific Phobia|Specific Phobia, Situational|Specific Phobia, Animal|Specific Phobia, Natural Environment|Childhood Anxiety Disorder
Interventions: BEHAVIORAL: Virtual Reality Exposure Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addition of Magnesium Sulfate to Caudal to Prevent Postoperative Emergence Agitation.
Status: UNKNOWN
Conditions: Agitation|Pediatric Disorder
Interventions: DRUG: Magnesium Sulfate|DRUG: 0.9%normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: DHACM in Robotic Assisted Laparoscopic Prostatectomy (RALP)
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: PROCEDURE: RALP using full nerve sparing technique|OTHER: dHACM Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nicotinic Acid as Add on Therapy in Patients Receiving β Blocker for Prophylaxis of Moderate to Severe Migraine
Status: RECRUITING
Conditions: Migraine Prophylaxis
Interventions: DRUG: Nicotinic Acid 500 MG Extended Release Oral Tablet|DRUG: Nicotinic Acid 1000 MG Extended Release Oral Tablet|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating Mobility Interventions in the Real World
Status: RECRUITING
Conditions: Lower Limb Amputation|Drop Foot
Interventions: DEVICE: Lower limb prostheses|DEVICE: Orthoses for Drop-foot|DEVICE: Footwear
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pre-operative Versus Post-operative Vaginal Cleansing With Chlorhexidine Solution in Prevention Post-Cesarean Section Infection
Status: COMPLETED
Conditions: Post Cesarean Infectious Morbidity
Interventions: PROCEDURE: Chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Multichannel tDCS to Reduce Hypertonia in Patients With Prolonged DOC
Status: COMPLETED
Conditions: Vegetative State|Minimally Conscious State|Spasticity, Muscle|Disorder of Consciousness
Interventions: DEVICE: tDCS|DEVICE: sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Automate Detection of Sleep Apnea by ApneascanTM
Status: COMPLETED
Conditions: Sleep Apnea|Arrhythmias
Interventions: OTHER: Apneascan TM|DEVICE: Polysomnography/polygraphy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the NantHealth GPS Cancer Test in Patients With Advanced Cancers
Status: TERMINATED
Conditions: Pancreatic Cancer|Metastatic Breast Cancer|Metastatic Lung Cancer|Metastatic Colon Cancer|Metastatic Melanoma|Metastatic Prostate Cancer
Interventions: DIAGNOSTIC_TEST: NantHealth GPS Cancer Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Aquatic Aerobic Training, Cardiorespiratory and Metabolic Variables in Coronary Artery Disease
Status: COMPLETED
Conditions: Arteriosclerosis, Coronary
Interventions: OTHER: Exercise, Aerobic (Water based)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role Of Laserpuncture For Prevention Of Nausea And Vomiting Post Strabismus Surgery With General Anesthesia In Adult Patients
Status: RECRUITING
Conditions: Nausea and Vomiting, Postoperative
Interventions: DEVICE: Laserpuncture|DEVICE: Sham Laserpuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intratumoral INT230-6 Followed by Neoadjuvant Immuno-chemotherapy in Patients With Early TNBC. INVINCIBLE-4-SAKK
Status: NOT_YET_RECRUITING
Conditions: Triple-negative Breast Cancer|TNBC - Triple-Negative Breast Cancer
Interventions: DRUG: INT230-6|OTHER: neoadjuvant immuno-chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxygen Therapy During Acute Respiratory Failure in Immuno-compromised Patients
Status: COMPLETED
Conditions: Acute Respiratory Failure|Immunocompromised Host|High Flow Oxygen Cannula
Interventions: DEVICE: High Flow Nasal Canula (HFNC)|DEVICE: Venturi mask|DRUG: Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Clinical Study to Compare the Efficacy and Safety of HLX07 + Serplulimab +Chemotherapy Versus Placebo + Serplulimab + Chemotherapy in First-Line Treatment of Patients With Recurrent or Metastatic NPC
Status: ACTIVE_NOT_RECRUITING
Conditions: Nasopharyngeal Carcinoma by AJCC V8 Stage
Interventions: DRUG: HLX07|DRUG: HLX10|DRUG: placebo|DRUG: chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intermittent Fasting on Metabolic Disease
Status: RECRUITING
Conditions: Individuals With Metabolic Disease
Interventions: BEHAVIORAL: time-restricted fasting for 4 weeks|BEHAVIORAL: 5:2 regimen for 4 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnosis of Diaphragmatic Paralysis After Interscalene Block: Feasibility and Impact Observed
Status: COMPLETED
Conditions: Shoulder Fractures|Arm Fractures
Interventions: OTHER: Ultrasound scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Cosopt® Vs Xalacom® on Ocular Hemodynamics and Intraocular Pressure (IOP) in Primary Open-angle Glaucoma (POAG)
Status: WITHDRAWN
Conditions: Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Dorzolamide+Timolol Maleate0.5%|DRUG: Latanoprost+Timolol Maleate0.5%+Lytears
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: The LYSA (Linking You to Support and Advice) Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Survivorship|Breast Cancer|Cervical Cancer|Endometrial Cancer
Interventions: OTHER: Survivorship Clinic Assessments|OTHER: Survivorship Clinic Nurse Resource|OTHER: Survivorship Clinic Dietitian Resource
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Opioid-Free Anesthetic for Tonsillectomy
Status: RECRUITING
Conditions: Anesthesia|Opioid Use|Tonsillitis|Sleep Disorder|Surgery
Interventions: DRUG: Ketorolac|DRUG: Dexmedetomidine|DRUG: Morphine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Bevacizumab Injection in Primary Pterygium in Tunisian Patients
Status: COMPLETED
Conditions: Pterygium
Interventions: DRUG: Preoperative Intra-lesional Bevacizumab Injection in primary pterygium|PROCEDURE: pterygium surgery without adjunctive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study Evaluating Chemotherapy in Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DRUG: Cabazitaxel + Androgen deprivation therapy|DRUG: Androgen deprivation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vismodegib After Stem Cell Transplant in Treating Patients With High-Risk First Remission or Relapsed Multiple Myeloma
Status: COMPLETED
Conditions: DS Stage I Plasma Cell Myeloma|DS Stage II Plasma Cell Myeloma|DS Stage III Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: DRUG: Vismodegib|OTHER: Pharmacological Study|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Mitoxantrone Hydrochloride Liposome Injection in Advanced Recurrent or Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Advanced Recurrent or Metastatic Breast Cancer
Interventions: DRUG: Mitoxantrone Hydrochloride Liposome Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel & Cyclophosphamide With or Without Trastuzumab Before Surgery in Treating Previously Untreated Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Estrogen Receptor Negative|Estrogen Receptor Positive|HER2/Neu Negative|HER2/Neu Positive|Invasive Breast Carcinoma|Progesterone Receptor Negative|Progesterone Receptor Positive|Stage IA Breast Cancer|Stage II Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage III Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Triple-Negative Breast Carcinoma
Interventions: DRUG: Cyclophosphamide|DRUG: Doxorubicin Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel|RADIATION: Radiation Therapy|PROCEDURE: Therapeutic Conventional Surgery|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alzheimer's in Long-Term Care--Treatment for Agitation
Status: COMPLETED
Conditions: Alzheimer Disease|Psychomotor Agitation
Interventions: DRUG: prazosin|DRUG: placebo (inert substance)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of the Japanese Encephalitis Vaccine IC51 (IXIARO®) in a Pediatric Population
Status: COMPLETED
Conditions: Encephalitis
Interventions: BIOLOGICAL: IC51 Japanese Encephalitis|BIOLOGICAL: Havrix®720|BIOLOGICAL: Prevnar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment of Ovarian Reserve After Laparoscopic Cystectomy Versus Aspiration/Electrocoagulation in the Treatment of Ovarian Endometrioma
Status: UNKNOWN
Conditions: Ovarian Endometrioma|Ovarian Reserve
Interventions: PROCEDURE: laparoscopic aspiration/electrocoagulation|PROCEDURE: laparoscopic cystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sintilimab Combined Intraperitoneal and Intravenous Paclitaxel Plus Oral S-1 in Gastric Cancer Patients With Peritoneal Metastasis
Status: UNKNOWN
Conditions: Gastric Cancer Stage IV|Peritoneal Metastases
Interventions: DRUG: sintilimab, paclitaxel and S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determine Safety and Effectiveness of Tadalafil in Asian Men When Taken as Needed for Getting and Keeping an Erection
Status: COMPLETED
Conditions: Impotence
Interventions: DRUG: tadalafil|DRUG: tadalafil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Emergency Department Probiotic Treatment of Diarrheal Illness on Daycare Attendance
Status: TERMINATED
Conditions: Gastroenteritis
Interventions: DRUG: Lacidophil (experimental high dose)|DRUG: Lacidophil (experimental standard dose)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Airway Pressure Release Ventilation and Intracranial Pressure in Patients With Severe Traumatic Brain Injury
Status: TERMINATED
Conditions: Injury, Brain, Traumatic|Traumatic Brain Injury
Interventions: OTHER: Airway Pressure Release Ventilation|OTHER: Low Tidal Volume Ventilation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vaccine Therapy in Treating Patients With Metastatic Melanoma
Status: TERMINATED
Conditions: Recurrent Melanoma|Stage IV Melanoma
Interventions: BIOLOGICAL: recombinant fowlpox-TRICOM vaccine|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy, Safety and Pharmacokinetics of CT041 Autologous CAR T-cell Injection
Status: RECRUITING
Conditions: Gastric Adenocarcinoma|Pancreatic Cancer|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: CT041 autologous CAR T-cell injection|DRUG: Physician's Choice（Paclitaxel or Irinotecan or Apatinib or Anti-PD-1 antibody）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Recombinant NAPc2 to Prevent Tumor Progression and Metastases in Metastatic Colon Cancer
Status: SUSPENDED
Conditions: Colon Cancer
Interventions: DRUG: recombinant nematode anticoagulant protein c2 (rNAPc2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Short Term Feeding for Asian Patients With Liver Cirrhosis
Status: COMPLETED
Conditions: CIRRHOSIS
Interventions: DIETARY_SUPPLEMENT: Osmolite and B.C.A.A.|DIETARY_SUPPLEMENT: Normal oral intake & supplementation if necessary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label 18-Month Safety Study of Fluorouracil Cream 0.5% for the Treatment of Actinic Keratoses
Status: COMPLETED
Conditions: Actinic Keratoses
Interventions: DRUG: fluorouracil cream 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of ppROM With Erythromycin vs. Azithromycin Trial
Status: TERMINATED
Conditions: Preterm Premature Rupture of Membranes (PPROM)
Interventions: DRUG: Azithromycin|DRUG: Erythromycin|DRUG: Ampicillin|DRUG: Amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Increasing Time Spent Outdoors on Myopia Prevention in School-Aged Children in Northeast China
Status: COMPLETED
Conditions: Myopia
Interventions: BEHAVIORAL: increasing time spent outdoors
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Continuous Interscalene Block vs Liposomal Bupivacaine After Proximal Humerus Fracture Surgery
Status: UNKNOWN
Conditions: Shoulder Fractures
Interventions: DRUG: Liposomal bupivacaine|DRUG: Standard bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Disease Prevention in Clinical Practice Base on Patient Specific Physiology
Status: ENROLLING_BY_INVITATION
Conditions: PreDiabetes|Insulin Resistance|Type2 Diabetes|NASH - Nonalcoholic Steatohepatitis|Diastolic Dysfunction|Dementia|Atrial Fibrillation|Cancer|Atherosclerosis|Carotid Plaque
Interventions: OTHER: Lifestyle modification in routine care of patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Time-Restricted Eating, Exercise and Cardiometabolic Health in Obesity
Status: RECRUITING
Conditions: Time Restricted Feeding|Exercise|Hepatic Steatosis|Cardiometabolic Syndrome|Obesity
Interventions: BEHAVIORAL: Time-restricted eating intervention|BEHAVIORAL: Exercise intervention|BEHAVIORAL: Time-restricted eating plus exercise intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Plaque Removal Efficacy of a U-Shaped Sonic Power Toothbrush in Children
Status: COMPLETED
Conditions: Dental Plaque
Interventions: DEVICE: Experimental: U-shaped Power Toothbrush|DEVICE: Placebo Comparator: Soft Manual Toothbrush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT