pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Selective Image Guided Resection of Axillary Lymph Nodes
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: Fine Needle Aspiration (FNA)|PROCEDURE: Ultrasound|PROCEDURE: Breast Surgery + Lymph Node Removal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rapid HIV Testing and Counseling in Drug Abuse Treatment
Status: COMPLETED
Conditions: Substance-Related Disorders
Interventions: BEHAVIORAL: On-site HIV rapid test and brief, prevention counseling|BEHAVIORAL: On- site HIV rapid test & information|BEHAVIORAL: Referral for off-site HIV testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Saline Injection Therapy in Atrophic Acne Scars
Status: COMPLETED
Conditions: Atrophic|Scars
Interventions: DRUG: saline injection therapy in post-acne atrophic scars
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindfulness: a Novel Approach for the Management of Diabetes-related Distress
Status: COMPLETED
Conditions: Emotional Distress|Type 2 Diabetes|Stress
Interventions: BEHAVIORAL: Mindfulness Based Stress Reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of All-trans Retinoic Acid With Chemotherapy Based in Paclitaxel and Cisplatin as First Line Treatment of Patients With Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small-Cell Lung Carcinoma
Interventions: DRUG: ATRA|OTHER: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of CD70-targeted CAR-T in the Treatment of CD70-positive Advanced/Metastatic Solid Tumors
Status: RECRUITING
Conditions: Metastatic Tumor|Advanced Solid Tumor|Renal Cell Carcinoma|Ovarian Cancer|Cervix Cancer
Interventions: BIOLOGICAL: CD70 CAR-T cells|BIOLOGICAL: CD70 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRI-Mapped Dose-Escalated Salvage Radiotherapy Post-Prostatectomy: The MAPS Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer|Prostate Adenocarcinoma
Interventions: RADIATION: Standard Salvage Radiation Treatment (SSRT)|RADIATION: Mapped Tumor Salvage RT (MTSRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial of Eculizumab in AQP4 Antibody-positive Participants With NMO (PREVENT Study)
Status: TERMINATED
Conditions: Neuromyelitis Optica|Neuromyelitis Optica Spectrum Disorder
Interventions: DRUG: Eculizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Clinical Study of the Efficacy and Safety of a Disposable Intravaginal Device for Stress Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: pessary (disposable intra-vaginal device)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: Placebo|DRUG: Guselkumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pain Control Following Vitreoretinal Surgery
Status: COMPLETED
Conditions: Retinal Detachment|Proliferative Vitreoretinopathy|Retinoschisis
Interventions: DRUG: Triamcinolone|DRUG: Bupivicaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study for Safety and Tolerability of TOP1288 Administered Rectally in Healthy and Ulcerative Colitis Subjects
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: TOP1288
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BetaPlus Survey - Observational Study to Assess Drug Adherence in Patients With Multiple Sclerosis After Conversion to Betaferon® by Using Elements of the BetaPlus Program
Status: COMPLETED
Conditions: Relapsing Remitting MS (RRMS)|Secondary Progressive MS (SPMS)
Interventions: DRUG: Interferon beta-1b (Betaseron, BAY86-5046)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Renal Sympathetic Denervation From The Adventitia on Hypertension
Status: COMPLETED
Conditions: Primary Aldosteronism Due to Aldosterone Producing Adenoma
Interventions: DEVICE: Renal Sympathetic Denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study To Establish The Effects Of PF-04457845 On Sleep In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy|Sleep
Interventions: DRUG: PF-04457845 / matched placebo|DRUG: PF-04457845 / matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Placenta Accreta Spectrum Management: Uterine Preservation Using JSICA Technique - Retrospective Cross-Sectional Study
Status: COMPLETED
Conditions: Placenta Accreta
Interventions: PROCEDURE: Jakarta Surgical Uterine Conservation (JSICA) Technique|PROCEDURE: Standard Hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Exercise Therapy Vs Mobilization With Movement Among Patients With Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DIAGNOSTIC_TEST: Movement With Mobilization|DIAGNOSTIC_TEST: Exercise Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of SIMPONI® to Arrest Beta-cell Loss in Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: BIOLOGICAL: Golimumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sleep-disordered Breathing and Perioperative Atrial Fibrillation in Cardiac Surgery
Status: UNKNOWN
Conditions: Elective Coronary Artery Bypass Grafting (CABG) Surgery|Coronary Artery Disease|Sleep-disordered Breathing (SDB)|Atrial Fibrillation
Interventions: OTHER: Stratification, no intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy, Safety, and Tolerability of Dihydroartemisinin-piperaquine + Mefloquine Compared to Dihydroartemisinin-piperaquine or Artesunate-mefloquine in Patients With Uncomplicated Falciparum Malaria in Cambodia
Status: COMPLETED
Conditions: Acute Falciparum Malaria
Interventions: DRUG: Dihydroartemisinin-piperaquine (DHA-PPQ)|DRUG: Mefloquine (MQ)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Tolerability of Different Doses of PF-05402536 and PF-06413367 in Healthy Adult Smokers.
Status: COMPLETED
Conditions: Smoking|Vaccines
Interventions: BIOLOGICAL: NIC7-001|BIOLOGICAL: NIC7-003|BIOLOGICAL: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploratory Single-arm, Single-center Adjuvant Treatment of Stage IIIB-IIIC Gastric Cancer With Combination of Palizumab and SOX Regimen
Status: RECRUITING
Conditions: Gastric Cancer Stage IIIB-IIIC
Interventions: DRUG: Pembrolizumab + SOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TRial to EvaluAte Tranexamic Acid Therapy in Thrombocytopenia
Status: COMPLETED
Conditions: Hematologic Neoplasms|Hemorrhage|Hematopoietic Stem Cell Transplantation
Interventions: DRUG: Tranexamic acid (TXA).|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Post-treatment Novmalized Urodynamiz Findings as the Golden Standard of Objective Cure for Female Overactive Bladder Patients Receiving Antimuscarinic Drug
Status: UNKNOWN
Conditions: Overactive Bladder Syndrome
Interventions: DRUG: Solifenacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Virtual Reality-based Medical Device for Patients With Depressive Disorder
Status: ENROLLING_BY_INVITATION
Conditions: Depressive Disorder|Major Depressive Disorder|Depressive Episode
Interventions: DEVICE: OMNIFIT DTx-MDD|OTHER: standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Retrospective Multicenter Investigation of the Use of the da Vinci® Surgical System in Non-Tumor Based TORS Procedures
Status: COMPLETED
Conditions: Subjects Who Have Undergone Benign Non-tumor TORS Procedures Using the da Vinci Surgical System
Interventions: DEVICE: robotic surgery using the da Vinci Surgical System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatments for Recovery of Hand Function in Acute Stroke Survivors
Status: COMPLETED
Conditions: Stroke, Acute|Stroke|Hemiparesis|Hemiplegia
Interventions: DEVICE: Neuromuscular electrical stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: One vs Two Visits Root Canal Treatments in Infected Teeth
Status: RECRUITING
Conditions: Apical Periodontitis|Pain|Tooth Loss|Dental Pulp Necrosis
Interventions: PROCEDURE: 1 visit root canal treatment (endodontics)|PROCEDURE: 2 visits root canal treatment (endodontics)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D and Calcium on Genes in the Colon
Status: COMPLETED
Conditions: Colorectal Polyps|Colorectal Adenoma|Adenocarcinoma
Interventions: DRUG: placebo and Calcitriol|DRUG: Calcium and Calcitriol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Different Ventilatory Strategy on Intraoperative Atelectasis During Bronchoscopy Under General Anesthesia.
Status: NOT_YET_RECRUITING
Conditions: Lung Disorder
Interventions: PROCEDURE: VESPA|PROCEDURE: conventional mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Propfol Versus Sevoflurane on Auditory and Cognitive Function
Status: COMPLETED
Conditions: Cognitive Dysfunction|Auditory Dysfunction, Central
Interventions: DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Preliminary Study Concerning the Validity of Parathyroid Exploration on a CZT Camera
Status: UNKNOWN
Conditions: Primary Hyperparathyroidism
Interventions: DEVICE: Tomoscintigraphic parathyroid imaging on a CZT camera
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Skin Dressings Versus Lubrication to Prevent Pressure Ulcers: A Randomized Trial
Status: TERMINATED
Conditions: Pressure Ulcer
Interventions: COMBINATION_PRODUCT: Skin dressing|OTHER: Moisturizing cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sorafenib and Micro-therapy Guided by Primovist Enhanced MRI in Patients With Inoperable Liver Cancer
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: RFA|PROCEDURE: Radioembolization (SIRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-Reader Retrospective Study Examining Carebot AI CXR 2.0.21-v2.01 Implementation in Everyday Radiology Clinical Practice
Status: COMPLETED
Conditions: Pneumothorax|Pulmonary Nodule, Solitary|Atelectasis|Subcutaneous Emphysema|Cardiomegaly|Consolidation|Pleural Effusion
Interventions: DEVICE: Carebot AI CXR
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Targeted Plasticity Therapy for Upper Limb Rehabilitation in Spinal Cord Injuries
Status: RECRUITING
Conditions: Spinal Cord Injuries|Upper Extremity Paresis
Interventions: DEVICE: Active Vagus Nerve Stimulation|DEVICE: Placebo Vagus Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Evaluating the Safety and the Biological Effects of Intratumoral Interferon Gamma and a Peptide-Based Vaccine in Patients With Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: BIOLOGICAL: A combination of intratumoral IFN-gamma plus systemic vaccination with MELITAC 12.1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Altitude Sickness Prevention With Ibuprofen Relative to Acetazolamide and Treatment Efficacy
Status: COMPLETED
Conditions: Acute Mountain Sickness
Interventions: DRUG: Ibuprofen|DRUG: Acetazolamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Group-based Treatment for Self-stigma in People With Mental Disorders in North-east Italy
Status: NOT_YET_RECRUITING
Conditions: Stigma|Mental Disorders|Self-stigma
Interventions: BEHAVIORAL: Narrative Enhancement Cognitive Therapy (NECT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Utility of an Amniotic Membrane Allograft for Diabetic Foot Ulcer Wound Management
Status: NOT_YET_RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: Orion TM Amniotic Membrane Allograft|PROCEDURE: Standard of Care (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Helicobacter Pylori Treatment on Idiopathic Central Serous Chorioretinopathy (ICSCR)
Status: COMPLETED
Conditions: Central Serous Chorioretinopathy
Interventions: DRUG: omeprazole, Amoxicillin, metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Reuteri DSM 17938 in Functional Constipation
Status: COMPLETED
Conditions: Functional Constipation
Interventions: DIETARY_SUPPLEMENT: L. reuteri DSM 17938|OTHER: Placebo Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ph II Trial of a Novel Anti-angiogenic Agent in Combination With Chemotherapy for the Second-line Treatment of Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer (CRC)
Interventions: DRUG: Irinotecan|DRUG: 5-Fluorouracil (bolus)|DRUG: 5-Fluorouracil (infusional)|DRUG: Leucovorin calcium|DRUG: CT-322|DRUG: Bevacizumab|DRUG: Bevacizumab Placebo (saline solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Social Skills Training for Patients With Late-Life Schizophrenia: a Pilot Study
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: CBSST plus treatment as usual|BEHAVIORAL: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of BCMA-targeted CAR-T Cells Therapy for Refractory/Relapsed Multiple Myeloma
Status: RECRUITING
Conditions: Relapse Multiple Myeloma|Refractory Multiple Myeloma
Interventions: BIOLOGICAL: BCMA Targeted CAR T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Calcium Channel Blocker on the Serum Fibrobalst Growth Factor-23 (FGF-23) Levels in Type-2 Diabetic Patients With Proteinuria Purpose
Status: COMPLETED
Conditions: We Searched for the Effects of Calcium Channel Blocker Amlodipine on the Clinical and Laboratory Parameters of Diabetic Patients With Proteinuria.
Interventions: DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study to Investigate the Effect of the A1 Agonist Capadenoson on Ventricular HR in Patients With Persistent or Permanent Atrial Fibrillation.
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Capadenoson (BAY68-4986)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Notch Signalling Pathway Inhibitor for Patients With Advanced Breast Cancer (0752-014)
Status: COMPLETED
Conditions: Advanced Breast Cancer|Other Solid Tumors
Interventions: DRUG: Comparator: MK0752, Notch Inhibitor|DRUG: Comparator: MK0752, Notch Inhibitor - 450 mg|DRUG: Comparator: MK0752, Notch Inhibitor - 3 days on, 4 off|DRUG: Comparator: MK0752, Notch Inhibitor - 1 day on, 6 off|DRUG: Comparator: MK0752, Notch Inhibitor - 3 days on, 4 off 350 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Sufentanil NanoTab for Management of Acute Pain Following Bunionectomy
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: Sufentanil NanoTab 20 mcg|DRUG: Sufentanil NanoTab 30 mcg|DRUG: Placebo NanoTab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nonmyeloablative Allo Stem Cell Transplant for Severe Autoimmune Diseases
Status: TERMINATED
Conditions: Systemic Lupus Erythematosus|Systemic Sclerosis
Interventions: PROCEDURE: Nonmyeloablative allogeneic stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incidence of Intraoperative Awareness in Indian Patient Population
Status: SUSPENDED
Conditions: Intraoperative Awareness
Interventions: DEVICE: Bi-spectral Index (BIS QUATRO REF #186-0106)|DEVICE: End tidal anaesthesia gas concentration (ETAG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neurorehabilitation Impact on Neurocognitive Impairments in Cerebellar Lesions
Status: NOT_YET_RECRUITING
Conditions: Cerebellum; Injury
Interventions: OTHER: Neurorehabilitation cerebellar cognitive disorder
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abundance of a Natural Odour in Human Cerebrospinal Fluid After Olfactory Exposure
Status: NOT_YET_RECRUITING
Conditions: Overweight and Obesity
Interventions: COMBINATION_PRODUCT: Inhalation - Natural Odour|COMBINATION_PRODUCT: Inhalation - Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone Inhibition
Status: TERMINATED
Conditions: Hyperandrogenemia|Polycystic Ovary Syndrome
Interventions: DRUG: Progesterone|DRUG: Estrace (estrogen)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: EaRly impAct theraPy With Ceftazidime-avibactam Via rapID Diagnostics
Status: RECRUITING
Conditions: Blood Stream Infections|Ventilator Associated Pneumonia|Healthcare Associated Infection|Carbapenem-Resistant Enterobacteriaceae Infection|Hospital-acquired Pneumonia
Interventions: DIAGNOSTIC_TEST: Rapid Diagnostics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Effectiveness and Safety of YVOIRE Y-Solution 720 Injected Into the Mid-Face
Status: COMPLETED
Conditions: Volume Defects in the Mid-face
Interventions: DEVICE: YVOIRE Y-Solution 720
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Health and Functional Status in Patients With Chronic Obstructive Pulmonary Disease During Therapy With Spiolto® Respimat® (AERIAL®)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Spiolto® Respimat®
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adjunctive Allogeneic Mesenchymal Stem Cells for Treatment-resistant Bipolar Depression
Status: RECRUITING
Conditions: Treatment-resistant Bipolar Depression
Interventions: BIOLOGICAL: Allogeneic Bone Marrow Derived Multipotent Mesenchymal Stromal Cells (MSCs)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Low-dose Ketamine in Pediatric Sickle Cell Vaso-occlusive Crisis
Status: COMPLETED
Conditions: Sickle Cell Disease|Vaso-Occlusive Crisis
Interventions: DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effectiveness of a Community Exercise Program to Reduce the Risk of Metabolic Syndrome Among Black Americans
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: BEHAVIORAL: Community-Based Exercise Program (C-FIT)|BEHAVIORAL: Self-Help Exercise Program (HOME)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy and Safety of Omacor, Co-Administered With Atorvastatin, in Subjects With Hypertriglyceridemia
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DRUG: Lovaza (omega-3-acid ethyl esters) [formerly known as Omacor] plus atorvastatin|DRUG: atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ramucirumab (LY3009806) or Necitumumab (LY3012211) Plus Osimertinib in Participants With Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Ramucirumab|DRUG: Necitumumab|DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Analysis of BRCAness
Status: UNKNOWN
Conditions: Ovarian Neoplasm Epithelial|Homologous Recombination Deficiency|BRCA1 Mutation|BRCA2 Mutation
Interventions: DIAGNOSTIC_TEST: Functional RAD51 assay|DRUG: Olaparib Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Exploratory Study of Perioperative Venous Access in Obese Patients
Status: NOT_YET_RECRUITING
Conditions: Catheter Complications
Interventions: OTHER: Long peripheral venous catheters for use|OTHER: Midline catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: DilAtation Versus Endoscopic Laser Resection in Simple Benign trAcheal sTEnosis
Status: RECRUITING
Conditions: Tracheal Stenosis
Interventions: PROCEDURE: Endoscopic laser resection|PROCEDURE: Dilatation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Study Between EDP-305, Fluconazole and Quinidine in Healthy Volunteers
Status: COMPLETED
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: DRUG: Fluconazole|DRUG: Quinidine|DRUG: EDP-305|DRUG: EDP-305
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of Dapagliflozin Effect on Diabetic Endothelial Dysfunction of Brachial Artery
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Coronary Artery Disease|Carotid Artery Diseases
Interventions: DRUG: Dapagliflozin 10 mg|DRUG: Glibenclamide 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Chemoradiotherapy With or Without Pembrolizumab (MK-3475) For The Treatment of Locally Advanced Cervical Cancer (MK-3475-A18/KEYNOTE-A18/ENGOT-cx11/GOG-3047)
Status: ACTIVE_NOT_RECRUITING
Conditions: Uterine Cervical Neoplasms
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Placebo for pembrolizumab|DRUG: Cisplatin|RADIATION: External Beam Radiotherapy (EBRT)|RADIATION: Brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Ultrasound Via Sonolucent Cranioplasty
Status: RECRUITING
Conditions: Cranioplasty|Sonolucent Cranioplasty|Reconstructive Cranioplasty
Interventions: DIAGNOSTIC_TEST: Transcranial Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 1 Study to Investigate the Safety and Pharmacokinetics of ABBV-CLS-7262 in Patients With Amyotrophic Lateral Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: ALS|Amyotrophic Lateral Sclerosis
Interventions: DRUG: ABBV-CLS-7262|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Prabotulinum and Onabotulinum Toxin-A for Facial Wrinkles
Status: COMPLETED
Conditions: Face|Skin Fold|Rejuvenation
Interventions: DRUG: Onabotulinum toxin A|DRUG: Prabotulinumtoxin A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I MAD, Fed-Fasted, CSF Study of UE2343 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: UE2343|DRUG: Placebo|DRUG: Placebo|DRUG: UE2343|DRUG: UE2343
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral Dexmedetomidine, Ketamine, Or Midazolam as Preioperative Medications.
Status: RECRUITING
Conditions: Anesthesia
Interventions: DRUG: oral Dexmedetomidine|DRUG: oral ketamine|DRUG: oral Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: RAGE Inhibition to Decrease Cardiotoxicity in Women With Early Breast Cancer
Status: RECRUITING
Conditions: Cancer Related Cognitive Decline|Non-metastatic Breast Cancer
Interventions: DRUG: TTP488|DRUG: ddAC/ddT|DRUG: TC|DRUG: TCHP|DRUG: Chemotherapy regimen that includes ddAC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Ketamine on the WAVCNS Index During General Anesthesia: A Feasibility Study
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Ketamine|DEVICE: NeuroSENSE monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Imaging-Transrectal Ultrasound Fusion Image-Guided Prostate Biopsy Following Radical Prostatectomy in Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: therapeutic conventional surgery|PROCEDURE: ultrasound-guided prostate biopsy|PROCEDURE: magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ImmunoTEP With 68-Ga in Metastatic Colo Rectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: TF2 antibody/68Ga-IMP-288
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of REduction And DIscontinuation Treatment of TKI (Imatinib, Nilotinib, Dasatinib and Bosutinib)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Myeloid Leukemia|Chronic Myeloid Leukemia in Remission|BCR-ABL Positive Chronic Myelogenous Leukemia
Interventions: DRUG: Imatinib|DRUG: Nilotinib|DRUG: Dasatinib|DRUG: Bosutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing One Intraarticular Injection of a Novel HYAJOINT Plus With Synvisc-One for the Treatment of Knee OA
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: HYAJOINT Plus|DEVICE: Synvisc-One
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Partial-thickness/Non-advanced vs. Full-thickness/MCAT Tunnelling for the Treatment of Multiple Gingival Recessions
Status: RECRUITING
Conditions: Gingival Recession
Interventions: PROCEDURE: Split-thickness non-advanced tunnel (Zabalegui et al. 1999)|PROCEDURE: Full-thickness coronally-advanced tunnel (Aroca et al. 2010)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of C. Difficile Infection With Fecal Microbiota Transplantation (FMT)
Status: WITHDRAWN
Conditions: Clostridium Difficile Infection
Interventions: OTHER: Fecal microbiota
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identifying Prognostic Variables for Persistent UL Dysfunctions After Breast Cancer Treatment -Reliability and Validity
Status: RECRUITING
Conditions: Breast Cancer
Interventions: OTHER: assessment for upper limb dysfunction|OTHER: retest assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: AEG35156 and Docetaxel in Treating Patients With Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: AEG35156|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Inappropriate Secretion of FGF23 in Patients Followed in Hospital in a Context of Hypophosphatemia
Status: COMPLETED
Conditions: Hypophosphatemia Without Immediate Anteriority|Unexplained Hypophosphatemia
Interventions: BEHAVIORAL: unexplained hypophoshatemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of BMD Measurement by DEXA to BeamMed Speed-of-Sound Measurement at Forearm in Patients With Gaucher Disease
Status: COMPLETED
Conditions: Gaucher Disease Type 1
Interventions: DEVICE: BeamMed Speed-of-Sound bone strength test at forearm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Clinical Study of Pyrotinib in Neoadjuvant Therapy of HR-positive and HER2-positive Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: COMBINATION_PRODUCT: Neoadjuvant therapy: TCbHPy|COMBINATION_PRODUCT: Neoadjuvant therapy: TCbHP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interferon Alpha Lozenges in the Prevention of Winter Colds and Flu
Status: COMPLETED
Conditions: Upper Respiratory Tract Infections
Interventions: DRUG: interferon-alpha|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective Randomized Multi-center Study for Efficacy of Metallic Biliary Stent Compared to Plastic Stent in Patients Receiving Neoadjuvant Chemotherapy for Resectable Pancreatic Cancer
Status: UNKNOWN
Conditions: Resectable Pancreatic Cancer With Biliary Obstruction
Interventions: DEVICE: ERCP using plastic stent|DEVICE: ERCP using metal stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Occupational Therapy-Delivered Cognitive Behavioral Therapy for Symptomatic Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: BEHAVIORAL: ENGAGE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of SGN-40, Lenalidomide, and Dexamethasone in Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: SGN-40|DRUG: lenalidomide|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of Topiramate in the Treatment of Patients With Epilepsy.
Status: COMPLETED
Conditions: Epilepsy|Epilepsies, Partial|Seizures
Interventions: DRUG: topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: An Intervention Program to Reduce to the Risk of Persistent Symptoms After Concussion
Status: COMPLETED
Conditions: Mild Traumatic Brain Injury
Interventions: BEHAVIORAL: Treatment as usual|BEHAVIORAL: Cognitive-behavioural therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Phase IV Trial to Evaluate Breast Brachytherapy Using the Mammosite-Ml®
Status: COMPLETED
Conditions: Breast Cancer|Ductal Carcinoma in Situ
Interventions: DEVICE: Mammosite ML|DEVICE: Mammosite ML
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tailored Health Self-Management Interventions for Highly Distressed Caregivers: Family Members of Persons With Dementia
Status: COMPLETED
Conditions: Stress|Carer Stress Syndrome|Dementia|Alzheimer Disease
Interventions: BEHAVIORAL: Biofeedback Training|OTHER: Dementia Education|BEHAVIORAL: Resourcefulness Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of The Effect of Altitude on Mircera (Methoxy Polyethylene Glycol-Epoetin Beta) Dose Requirements in Participants With Chronic Renal Anemia in Pre-Dialysis or Dialysis
Status: COMPLETED
Conditions: Anemia, Kidney Disease, Chronic
Interventions: DRUG: Methoxy polyethylene glycol-epoetin beta
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chiron Corp HCV E1/E2 Vaccine
Status: COMPLETED
Conditions: Hepatitis C
Interventions: BIOLOGICAL: HCV E1E2/MF59|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Experimental Neck Pain in Healthy Participants
Status: UNKNOWN
Conditions: Healthy|Neck Pain
Interventions: OTHER: Injection of Isotonic saline|OTHER: Injection of NGF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study to Evauate the Pharmacokinetic Profiles and Safety of CKD-348 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CKD-828, D097, D337, CKD-348 T1, CKD-348 T2|DRUG: CKD-348 T1, CKD-348 T2, CKD-828, D097, D337,|DRUG: CKD-348 T2, CKD-348 T1, CKD-828, D097, D337
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgery and Radiation Therapy With or Without Chemotherapy in Treating Patients With Mouth Cancer
Status: UNKNOWN
Conditions: Head and Neck Cancer
Interventions: DRUG: cisplatin|DRUG: fluorouracil|PROCEDURE: conventional surgery|RADIATION: low-LET cobalt-60 gamma ray therapy|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Inference-Based Cognitive Therapy Versus Exposure and Response Prevention for Obsessive-Compulsive Disorder
Status: RECRUITING
Conditions: Obsessive-compulsive Disorders and Symptoms|Obsessive-Compulsive Disorder
Interventions: BEHAVIORAL: Exposure and response prevention|OTHER: Inference-based cognitive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunization With a Pentavalent Vaccine Composed of KLH-conjugates of GD2L, GD3L, Globo H, Fucosyl GM1, and N-Propionylated Polysialic Acid
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: vaccine comprised of KLH conjugates of GD2L, GD3L, Globo H, fucosyl GM1, and N-propionylated polysialic acid plus OPT-821 adjuvant|BIOLOGICAL: Biological/Vaccine: vaccine comprised of KLH conjugates of GD2L, GD3L, Globo H, fucosyl GM1, and N-propionylated polysialic acid plus OPT-821 adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glofitamab Combination With Chidamide in Patients With Recurrent/Refractory DLBCL
Status: NOT_YET_RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma-Recurrent|Diffuse Large B-Cell Lymphoma-Refractory
Interventions: DRUG: Glofitamab|DRUG: Chidamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing Optimal Inhaler Strategies During Acute Exacerbations of COPD (AECOPDs) Using Oscillometry
Status: RECRUITING
Conditions: COPD|COPD Exacerbation Acute
Interventions: DRUG: Long-acting bronchodilator therapy (LABD)|DRUG: Short-acting bronchodilator therapy (SABD)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Paracetamol, Pregabalin and Dexamethasone on Pain and Opioid Requirements in Patients Having a Tonsillectomy
Status: TERMINATED
Conditions: Pain, Postoperative
Interventions: DRUG: paracetamol + placebo + placebo|DRUG: paracetamol + pregabalin + placebo|DRUG: paracetamol + pregabalin + dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sitafloxacin and Ertapenem Treatment for Acute Pyelonephritis Caused by Escherichia Coli
Status: UNKNOWN
Conditions: Infection Due to Escherichia Coli|Acute Pyelonephritis
Interventions: DRUG: Sitafloxacin|DRUG: Ertapenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Quality and Mechanisms of Cardiovascular Risks in Adults With Hypertension
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension|Insomnia
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia (CBT-I)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Fluoroscopic Anterior Approach Versus Ultrasound Guided Superior Hypogastric Plexus Neurolysis in Cancer Pelvic Pain
Status: UNKNOWN
Conditions: Pain Cancer
Interventions: OTHER: Group US-guided|OTHER: Group fluoroscopy-guided
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lithium Versus Cariprazine in the Acute Phase Treatment of Bipolar Depression (DUAG9)
Status: RECRUITING
Conditions: Depression, Bipolar
Interventions: DRUG: Lithium|DRUG: Cariprazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of MONTAGE in Adults With Spinal Deformity Undergoing Pedicle Subtraction Osteotomy
Status: TERMINATED
Conditions: Fused Vertebrae|Ankylosing Spondylitis|Sagittal Deformities|Thoracolumbar Kyphosis
Interventions: DEVICE: Experimental: Montage Bone Hemostat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of Inactivated Vaccine for Prevention of COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Two doses of low dosage inactivated SARS-CoV-2 vaccine at the schedule of day 0,28|BIOLOGICAL: Two doses of medium dosage inactivated SARS-CoV-2 vaccine at the schedule of day 0,28|OTHER: Two doses of placebo at the schedule of day 0,28
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Actifuse ABX and Local Bone in Spinal Surgery
Status: TERMINATED
Conditions: Scoliosis|Kyphosis|Lordosis
Interventions: PROCEDURE: Multilevel Spinal fusion with Actifuse ABX®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Whole Blood Bactericidal Activity Against Mycobacterium Tuberculosis of Pyrazinamide Plus Allopurinol in Healthy Volunteers
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: Pyrazinamide|DRUG: Allopurinol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Satisfaction Of Adult Patients With Gummy Smile Treated By Botulinum Toxin A Injection
Status: UNKNOWN
Conditions: Gummy Smile Due to Hypermobile Upper Lip
Interventions: DRUG: Botulinum Toxin A Injection|PROCEDURE: Modified Lip Repositioning Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Darxicilib Combined With Abiraterone Acetate Tablets (II) for the Treatment of Advanced Metastatic Castration-resistant Prostate Cancer.
Status: NOT_YET_RECRUITING
Conditions: The Efficacy of Abiraterone Acetate Combined With Dalpicilib in the Treatment of Patients With Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: Dalpicilib|DRUG: Abiraterone Acetate (II)|DRUG: Androgen Deprivation Therapy|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: F-18 3F4AP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Evaluation of an Investigational Soft Contact Lens
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Delefilcon A contact lens|DEVICE: Lotrafilcon B contact lens (O2 OPTIX, AIR OPTIX)|DEVICE: Nelfilcon A contact lens (DAILIES AquaComfort Plus)|DEVICE: Narafilcon A contact lens (1-DAY ACUVUE TRUEYE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Standard Treatment Versus Standard Treatment Plus Extracorporeal Life Support (ECLS) in Myocardial Infarction Complicated With Cardiogenic Shock
Status: TERMINATED
Conditions: Myocardial Infarction|Shock, Cardiogenic
Interventions: DEVICE: Extra-Corporeal Life Support -Impella 2.5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT