pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Subchondral and Intra-articular Application of Bone Marrow Concentrate for Knee Unicompartmental OA
Status: UNKNOWN
Conditions: Osteoarthritis, Knee|Cartilage Degeneration
Interventions: BIOLOGICAL: Subchondral and intra-articular injection of BMC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: E6201 Plus Dabrafenib for the Treatment of Metastatic Melanoma Central Nervous System Metastases (CNS)
Status: TERMINATED
Conditions: Malignant Melanoma|Brain Metastases
Interventions: DRUG: E6201|DRUG: E6201 plus dabrafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recovery Profiles After c Spine Surgery: With or Without Dexmedetomidine as an Anesthetic Adjuvant
Status: UNKNOWN
Conditions: Cervical Spondylosis
Interventions: DRUG: Dexmedetomidine|OTHER: NSS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Sublingual Cannabis Based Medicine Extracts With Placebo to Treat Brachial Plexus Injury Pain
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: GW-1000-02|DRUG: GW-2000-02|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Specific 3-Dimensional And 2-Dimensional Lumbar Traction In Patients With Lumbar Radiculopathy
Status: UNKNOWN
Conditions: Lumbar Radiculopathy|Radiculopathy
Interventions: OTHER: mechanical traction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Steroid Sparing Treatment With in Newly Diagnosed Transplant Ineligible Patients With Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Daratumumab|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of LDK378 in ROS1 and /or ALK Over-expressed Advanced Intrahepatic or Hilar Cholangiocarcinoma
Status: TERMINATED
Conditions: Cholangiocarcinoma
Interventions: DRUG: LDK378
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient Satisfaction and Crestal Bone Loss of Polymer Infiltrated Ceramic Network Versus Lithium Disilicate Implant Hybrid Abutment Crowns in Esthetic Zone
Status: UNKNOWN
Conditions: Hybrid Crowns on Single Implants in Esthetic Zone
Interventions: OTHER: Vita Enamic hybrid crown|OTHER: emax hybrid crown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Short-term Atorvastatin Treatment on Immune Responses to Pneumovax 23
Status: COMPLETED
Conditions: Healthy Controls
Interventions: DRUG: Atorvastatin|DRUG: Pneumovax 23|OTHER: Placebo (lactose pill)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Studying Gene Expression and Location in Samples From Patients With Brain Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: GENETIC: gene expression analysis|GENETIC: genetic linkage analysis|GENETIC: microarray analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Evaluation of Delefilcon A and Verofilcon A Daily Disposable Toric Soft Contact Lenses Over One Week of Wear
Status: COMPLETED
Conditions: Ocular Physiology
Interventions: DEVICE: TEST LENS|DEVICE: CONTROL LENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Self-expandable Metal Stent (SEMS) Endoscopic Placement for Malignant Colonic Obstruction Therapy
Status: RECRUITING
Conditions: Neoplasms,Colorectal
Interventions: PROCEDURE: Stoma formation|PROCEDURE: Endoscopic self-expandable metal stent placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Convalescent Antibodies Infusion in Critically Ill COVID 19 Patients
Status: TERMINATED
Conditions: Pneumonia, Ventilator-Associated|Coronavirus Infection
Interventions: BIOLOGICAL: Anti-coronavirus antibodies (immunoglobulins)obtained with DFPP from convalescent patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Therapeutic Neuromodulation for Anhedonic Depression
Status: RECRUITING
Conditions: Treatment Resistant Depression
Interventions: DEVICE: Active TBS-DLPFC|DEVICE: Active TBS-DMPFC|DEVICE: Sham TBS-DLPFC or DMPFC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Belinostat and Isotretinoin in Treating Patients With Solid Tumors That Are Metastatic or That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Adult Solid Neoplasm
Interventions: DRUG: Belinostat|DRUG: Isotretinoin|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate AB308 in Combination With AB122 in Participants With Advanced Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumor|Non Small Cell Lung Cancer (NSCLC)|Melanoma|Cervical Cancer|Multiple Myeloma|Lymphoma, Non-Hodgkin|Diffuse Large B Cell Lymphoma (DLBCL)|Gastric Cancer|Gastroesophageal Junction Adenocarcinoma|Esophageal Cancer
Interventions: DRUG: AB308|DRUG: Zimberelimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of VX-121 in Healthy Subjects and in Subjects With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Placebo (matched to VX-121 suspension)|DRUG: VX-121 (Suspension)|DRUG: TEZ/IVA|DRUG: IVA|DRUG: Placebo (matched to TEZ/IVA)|DRUG: Placebo (matched to IVA)|DRUG: VX-121 (Tablet)|DRUG: Placebo (matched to VX-121 tablet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fructose-induced Intestinal de Novo Lipogenesis
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: fat+protein meal|OTHER: Fat + protein + 13C fructose meal|OTHER: Fat+protein+13C fructose+glucose meal|OTHER: 13C Fat + whey protein|OTHER: 13C Fat + whey protein + glucose+ glucose meal
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Momelotinib Combined With Capecitabine and Oxaliplatin in Adults With Relapsed/Refractory Metastatic Pancreatic Ductal Adenocarcinoma
Status: TERMINATED
Conditions: Relapsed/Refractory Metastatic Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: Momelotinib (MMB)|DRUG: Capecitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Hepatic Arterial Infusion Combined With Apatinib and Camrelizumab for C-staged Hepatocellular Carcinoma in BCLC Classification
Status: RECRUITING
Conditions: C-staged Hepatocellular Carcinoma in BCLC Classification
Interventions: COMBINATION_PRODUCT: Hepatic Arterial Infusion combined with Apatinib and Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Actifuse ABX Versus INFUSE in Posterolateral Instrumented Lumbar Fusion (PLIF) With Interbody Fusion
Status: COMPLETED
Conditions: Degenerative Disc Disease
Interventions: PROCEDURE: Actifuse ABX|PROCEDURE: INFUSE, plus master granules (MGG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Camrelizumab in Combination With Docetaxel +S-1 as Adjuvant Treatment Therapy in Stage III Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer Stage III
Interventions: DRUG: Camrelizumab|DRUG: S-1|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chidamide With CHOP Regimen for de Novo PTCL Patients (CHOP: Cyclophosphamide, Etoposide, Vincristine and Prednisone; PTCL: Peripheral T Cell Lymphoma)
Status: UNKNOWN
Conditions: Peripheral T Cell Lymphoma
Interventions: DRUG: Chidamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paravertebral Block, an Adjunct to General Anaesthesia for Breast Surgery?
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: standard anaesthesia (bupivacaine)|DRUG: additional pvb (ropivacaine) and elastomeric disposable infusion pump|DRUG: additional pvb (ropivacaine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenously Administered Liposomal PROMITIL in Combination With External Beam Radiotherapy in Cancer Patients
Status: COMPLETED
Conditions: Cancer|Solid Tumor|Metastatic Disease
Interventions: DRUG: Promitil|RADIATION: EBR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Jules Bordet Institute Molecular Profiling Program Feasibility Trial
Status: COMPLETED
Conditions: Colorectal Cancer Metastatic|Metastatic Melanoma|Metastatic Non-Small Cell Lung Carcinoma
Interventions: PROCEDURE: Biopsy of a metastatic lesion.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Investigate the Safety and Efficacy of Lithium in Volunteers With Amyotrophic Lateral Sclerosis (ALS)
Status: TERMINATED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Lithium Carbonate|DRUG: Riluzole|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The ESTxENDS Trial- Electronic Nicotine Delivery Systems (ENDS/Vaporizer/E-cigarette) as an Aid for Smoking Cessation.
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: OTHER: ENDS (vaporizer/e-cig) and smoking cessation counseling|OTHER: Smoking cessation counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase III Clinical Study Comparing JS004 Plus Toripalimab With Investigator-Selected Chemotherapy in Patients With PD-(L)1monoclonal Antibody Refractory Classic Hodgkin Lymphoma (cHL)
Status: RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: BIOLOGICAL: JS004 in combination with Toripalimab|DRUG: Bendamustine or gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immune Response to Yellow Fever Vaccination in Adults With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: Live Yellow Fever Vaccine (YFV-17D)|DRUG: YFV-17D Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effectiveness of Stretching and Orthoses in Individuals With Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: DEVICE: Prefabricated Orthoses|OTHER: general and lumbrical muscle stretching|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Far Infrared Reflecting Sleepwear on Recovery and Sleep
Status: COMPLETED
Conditions: Exercise Induced Muscle Damage
Interventions: DEVICE: Far infrared reflecting sleepwear|DEVICE: Placebo sleepwear
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Tozorakimab|DRUG: Tozorakimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Study to Assess the Effect of Co-Administered Miravirsen and Telaprevir in Healthy Subjects
Status: COMPLETED
Conditions: Hepatitis C|Chronic Hepatitis C
Interventions: DRUG: Miravirsen sodium|DRUG: Telaprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Blood Sampling Site for Point of Care Lactate Assessment
Status: COMPLETED
Conditions: Blood Lactic Acid Increased|Hip Fractures
Interventions: DEVICE: Optimal Blood Sampling Site for Point of Care Lactate Assessment using the handled Lactate-Pro 2 device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pre-Study of Wild Type Enterotoxigenic E. Coli (ETEC) Strain for Verification of a Planned Challenge Dose
Status: RECRUITING
Conditions: ETEC Diarrhea
Interventions: OTHER: Enterotoxigenic E. coli (ETEC) strain
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Immediate Detection of Helicobacter Infection With a New Electrochemical System.
Status: COMPLETED
Conditions: H. Pylori Infection
Interventions: DEVICE: Electrochemical H. pylori detection method|DEVICE: IHC|DEVICE: C13-urea breath test|DEVICE: HUT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intra-monocyte Imiglucerase Kinetics in Gaucher Disease
Status: UNKNOWN
Conditions: Gaucher Disease
Interventions: DRUG: Imiglucérase (drug) pharmacokinetics
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dates on Plasma Lipids, Oxidative Stress and the Atherogenicity of Serum in Healthy Adults
Status: UNKNOWN
Conditions: Atherosclerosis
Interventions: DIETARY_SUPPLEMENT: dates
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intermittent Cefoxitin Administration Versus Loading Bolus Followed by Continuous Infusion for the Prevention of Surgical Site Infection in Colorectal Surgery
Status: RECRUITING
Conditions: Antibiotic Prophylaxis|Colorectal Surgery
Interventions: DRUG: Loading bolus of cefoxitin|DRUG: Intermittent cefoxitin|DRUG: Continuous infusion of placebo|DRUG: Continuous infusion of cefoxitin|DRUG: Intermittent placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of PET Tracers to Evaluate T Cell Change and Activation in Relation to Immunotherapy Treatment Response in Non-Small Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: NSCLC
Interventions: DRUG: [18F]F-AraG PET imaging|DRUG: [89Zr]Zr-Df-Crefmirlimab PET imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Assess the Safety and Efficacy of a Sunscreen on Acne-Prone Skin With Inflammatory and Non-Inflammatory Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: OTHER: Sunscreen SPF 70
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma|Glioblastoma Multiforme|GBM|Brain Cancer
Interventions: PROCEDURE: Tissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap to bypass the blood brain barrier (BBB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Multiple Dose Study of RZ358 in Patients With Congenital Hyperinsulinism
Status: COMPLETED
Conditions: Congenital Hyperinsulinism
Interventions: DRUG: RZ358 Sequential Group Cohort 1|DRUG: RZ358 Sequential Group Cohort 2|DRUG: RZ358 Sequential Group Cohort 3|DRUG: RZ358 Sequential Group Cohort 4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychosocial Support for African-American, Latina-American, or European-American Cervical Cancer Survivors
Status: COMPLETED
Conditions: Cancer Survivor|Cervical Cancer|Psychosocial Effects of Cancer and Its Treatment
Interventions: BEHAVIORAL: telephone-based intervention|OTHER: counseling intervention|OTHER: questionnaire administration|OTHER: study of socioeconomic and demographic variables|PROCEDURE: psychosocial assessment and care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oral ISL QM as PrEP in Cisgender Women at High Risk for HIV-1 Infection (MK-8591-022)
Status: TERMINATED
Conditions: HIV-I|Human Immunodeficiency Virus Type 1|Prophylaxis
Interventions: DRUG: Islatravir|DRUG: Placebo to FTC/TDF|DRUG: FTC/TDF|DRUG: Placebo to ISL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Sodium Lactate Versus Hypertonic Saline Solution in the Treatment of Intracranial Hypertensive Episodes in Severe Brain Injured Patients
Status: NOT_YET_RECRUITING
Conditions: Intra Cerebral Hypertension|Lactate Sodium Solution
Interventions: DRUG: Lactate, Sodium|DRUG: Hypertonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Inhaled PGE1 in Neonatal Hypoxemic Respiratory Failure
Status: WITHDRAWN
Conditions: Infant, Newborn|Respiratory Insufficiency|Pulmonary Hypertension|Respiratory Distress Syndrome, Newborn|Streptococcal Infections
Interventions: DRUG: Inhaled Prostaglandin E1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Blind Study of Ergoloid Mesylates, 5-HTP and the Combination in Adult Males With Fragile X Syndrome
Status: COMPLETED
Conditions: Fragile X Syndrome
Interventions: DIETARY_SUPPLEMENT: 5-Hydroxytryptophan / Vitamin B6|DRUG: Ergoloid Mesylate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of a New Antiviral Drug to Prevent Cytomegalovirus Reactivation in Bone Marrow Transplanted Patients
Status: COMPLETED
Conditions: HCMV Reactivation or HCMV End-Organ Disease
Interventions: DRUG: 60 mg AIC246|DRUG: 120 mg AIC246|DRUG: 240 mg AIC246|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Randomized Comparison of CLOpidogrel Monotherapy Versus Extended Dual-antiplatelet Therapy Beyond 12 Months After Implantation of Drug-eluting StEnts in High-risk Lesions or Patients; A-CLOSE Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease|DES
Interventions: DRUG: Clopidogrel mono-therapy|DRUG: Dual-antiplatelet therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thymoglobulin and Total Lymphoid Irradiation for Hematologic Malignancies
Status: COMPLETED
Conditions: Lymphoma|Leukemia
Interventions: DRUG: Thymoglobulin|RADIATION: Total Lymphoid Irradiation|PROCEDURE: Peripheral Blood Stem Cell Infusion|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of the Potential Inhibitory Effects of Ciclesonide Nasal Aerosol on the Hypothalamic-Pituitary-Adrenal Axis in Subjects 6-11 Years With Perennial Allergic Rhinitis
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis|PAR
Interventions: DRUG: ciclesonide nasal aerosol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sumamos Excelencia Project: Implementation of Best Practices in Clinical Practice (Thrid Edition)
Status: RECRUITING
Conditions: Pain|Obesity, Childhood|Breast Feeding|Incontinence, Urinary|Smoking Cessation|Pressure Injury|Fall
Interventions: OTHER: Multifaceted implementation strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Depressive and Anxiety Disorders in Patients With Chronic Liver Diseases
Status: NOT_YET_RECRUITING
Conditions: Depression, Anxiety
Interventions: DIAGNOSTIC_TEST: The Hamilton Rating Scale for Anxiety|DIAGNOSTIC_TEST: The Beck Depression inventory|DIAGNOSTIC_TEST: Rand SF-36 Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pegvisomant And Sandostatin LAR Combination Study
Status: COMPLETED
Conditions: Acromegaly
Interventions: DRUG: Pegvisomant/ Sandostatin LAR|DRUG: Sandostatin LAR|DRUG: Pegvisomant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brentuximab Vedotin After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies
Status: WITHDRAWN
Conditions: Hematopoietic/Lymphoid Cancer
Interventions: DRUG: brentuximab vedotin|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO
Status: COMPLETED
Conditions: Febrile Neutropenia|Hematological Malignancy
Interventions: DRUG: Discontinuation of imipenem-cilastatin or meropenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Neural Responses Induced by Antidepressant Effects
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Escitalopram|DRUG: Placebo|BEHAVIORAL: Real-time Neurofeedback fMRI task pre- and post-RCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Therapeutic Action of Tamsulosin and Finasteride in Symptomatic Benign Prostatic Hyperplasia (BPH) Patients
Status: COMPLETED
Conditions: Prostatic Hyperplasia
Interventions: DRUG: Tamsulosin|DRUG: Finasteride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Effects of Low-dose Rivaroxaban With Antiplatelet Therapies
Status: COMPLETED
Conditions: Coronary Artery Disease|Peripheral Arterial Disease|Atrial Fibrillation
Interventions: DRUG: Rivaroxaban 2.5 mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3D-printed Implant Overdentures
Status: COMPLETED
Conditions: Edentulous Mouth
Interventions: OTHER: (DLP)-printed photo-polymerizable PMMA Nextdent mandibular implant overdenture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of the "Spinomed Active" Orthosis on Chronic Back Pain in Women With Vertebral Fractures.
Status: COMPLETED
Conditions: Osteopenia|Kyphosis
Interventions: OTHER: Spinomed active
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparing the Efficacy of VHAG and Traditional Chemotherapy Regimens in Newly Diagnosed ETP-ALL
Status: RECRUITING
Conditions: ETP-ALL
Interventions: DRUG: Homoharringtonine|DRUG: venetoclax|DRUG: Cytarabine|DRUG: G-CSF|DRUG: Vindesine|DRUG: Daunorubicin|DRUG: cyclophosphamide|DRUG: Dexamethasone|DRUG: L-ASP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Use of Noninvasive Positive Pressure Ventilation for Intro-pulmonary Acute Lung Injury
Status: COMPLETED
Conditions: Acute Lung Injury
Interventions: PROCEDURE: noninvasive positive pressure ventilation|PROCEDURE: oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vancomycin Study in Multiple Sclerosis (MS)
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: Vancomycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Surgical Treatment Options for Primary Congenital and Developmental Glaucomas
Status: WITHDRAWN
Conditions: Primary Congenital Glaucoma|Developmental Glaucoma
Interventions: DEVICE: Santen PRESERFLO MicroShunt|PROCEDURE: Trabeculectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parasternal Block and TENS for Cardiac Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: parasternal block|DEVICE: TENS group|DEVICE: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Caudal Epidural With Non Opioid Adjuvants in Lumbosacral Spine Surgery
Status: COMPLETED
Conditions: Caudal Analgesia for Lumosacral Spine Surgeries
Interventions: DRUG: Bupivacaine|DRUG: Dexamethasone|DRUG: Dexmedetomidine|DRUG: Hyalouridinase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Efficacy of Music Therapy and Intravenous Midazolam 0.02 mg/kgBW in Reducing Preoperative Anxiety
Status: COMPLETED
Conditions: Cancer
Interventions: OTHER: Music therapy|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Role of Migraine Prophylaxis Agent Topiramate in Treating Patients With Sudden Sensorineural Hearing Loss
Status: RECRUITING
Conditions: Sudden Deafness|Sudden Sensorineural Hearing Loss
Interventions: DRUG: Topiramate|DRUG: Systemic Steroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypertension With Unsatisfactory Sleep Health
Status: COMPLETED
Conditions: Insomnia|Hypertension
Interventions: BEHAVIORAL: Brief Behavioral Treatment for Insomnia|BEHAVIORAL: Sleep Healthy Using the Internet|BEHAVIORAL: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1-2 of Azacitidine + Lenalidomide for Previously Untreated Elderly Patients With Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)|Adult Acute Myeloblastic Leukemia
Interventions: DRUG: Lenalidomide|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Trial of Irbesartan Tablets（0.15g） in Healthy Chinese Subjects
Status: UNKNOWN
Conditions: Irbesartan Tablets (0.15g/Tablet)|Under Fasted Condition|Under Fed Condition|Bioequivalence
Interventions: DRUG: Irbesartan Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antibiotics and the Prolongation of Pregnancy in Preterm Labor With an Advanced Cervical Exam
Status: TERMINATED
Conditions: Length of Pregnancy Prolongation in Hours
Interventions: DRUG: erythromycin and metronidazole (antibiotics)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of Left Atrial Mechanical Function With a True 3D Ultrasouns Arry and Comparison With the Transthoracic and Transesophageal Echocardiography
Status: UNKNOWN
Conditions: Comparison of 3D Monitored Changes of Left Atrial Volume Before and After Ablation With Conventional Transesophageal Echocardiography
Interventions: DEVICE: transesophageal investigation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 1 Study to Evaluate the Safety and Tolerability of EO1404 in the Treatment of Corneal Edema
Status: UNKNOWN
Conditions: Corneal Edema|Fuchs Dystrophy|Fuchs' Endothelial Dystrophy|Pseudophakic Bullous Keratopathy|Corneal Endothelial Dystrophy|Corneal Transplant Failure
Interventions: COMBINATION_PRODUCT: EO1404|PROCEDURE: Endothelial brushing or Descemet stripping
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Telmisartan Film-coated Tablet Compared With Two Tablets of the Conventional Telmisartan Tablet in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Telmisartan film-coated tablet|DRUG: Telmisartan uncoated tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Awake Transnasal Laser-assisted Surgery (TNLS) and Microlaryngeal Surgery for Benign Laryngeal Lesions
Status: COMPLETED
Conditions: Awake Laser|Microlaryngeal Surgery|Benign Laryngeal Lesion|Transnasal Laser Surgery
Interventions: PROCEDURE: Awake transnasal laser-assisted surgery (TNLS)|PROCEDURE: Microlaryngeal surgery (MLS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Kitasato PCI Registry
Status: RECRUITING
Conditions: Acute Coronary Syndrome|STEMI - ST-segment Elevation Myocardial Infarction|NSTEMI - Non-ST-Segment Elevation Myocardial Infarction|Atherosclerosis|Coronary; Ischemic|Stable Angina
Interventions: DEVICE: Intra-coronary imaging device|BEHAVIORAL: PCI procedural characteristics
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bone in CKD Alkali Response (BICARb Pilot Trial)
Status: RECRUITING
Conditions: Chronic Kidney Diseases|Bone Loss
Interventions: DRUG: Potassium citrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of a Rapid Diagnostic Test for Antibiotic De-escalation in Severe Community Acquired Pneumonia
Status: WITHDRAWN
Conditions: Community-acquired Pneumonia
Interventions: DIAGNOSTIC_TEST: BioFire Pneumonia Panel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Use of Fosfomycin as a Single Dose Oral Treatment of Asymptomatic Bacteriuria
Status: UNKNOWN
Conditions: Urinary Tract Infection
Interventions: DRUG: phosphomycin|DRUG: Culture specific antibiotic therapy|DIAGNOSTIC_TEST: Pre-treatment Urine Culture|DIAGNOSTIC_TEST: Antimicrobial sensitivity testing|DIAGNOSTIC_TEST: Post-treatment urine culture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Asynchronous Techniques for the Delivery of Empirically Supported Psychotherapies
Status: COMPLETED
Conditions: Depressive Symptoms|Anxiety|Stress|Impairment
Interventions: BEHAVIORAL: e-Health Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Cinobufacini Injection Combined With Oxaliplatin Regimen on Gastrointestine Carcinoma
Status: UNKNOWN
Conditions: Gastrointestinal Neoplasms
Interventions: DRUG: Cinobufacini injection|DRUG: chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ESSENCE 2: CyclASol for the Treatment of Signs and Symptoms of Dry Eye Disease (DED)
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: CyclASol topical ocular, eye drops|DRUG: Vehicle topical ocular, eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pegylated Interferon-alpha-2a in Patients With Malignant Melanoma Stage IIA-IIIB
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: pegylated interferon-alpha-2a|DRUG: interferon-alpha-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Telerehabilitation Use in the Treatment of Non-specific Chronic Low Back Pain in the Brazilian Afrodescendants
Status: ENROLLING_BY_INVITATION
Conditions: Telerehabilitation|Low Back Pain
Interventions: BEHAVIORAL: Graded Activity based in exercises and educational approach|OTHER: Educational Approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Brief Mindfulness and Relaxation Inductions on Anxiety, Affect and Brain Activation in Athletes
Status: COMPLETED
Conditions: State Anxiety|Affect|Electroencephalography
Interventions: BEHAVIORAL: Mindfulness induction (MI)|BEHAVIORAL: Relaxation (RI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective, Randomized, Multicentre, Open-label, Phase II / III Study to Assess Efficacy and Safety of Ranibizumab 0.5 mg Intravitreal Injections Plus Panretinal Photocoagulation (PRP) Versus PRP in Monotherapy in the Treatment of Subjects With High Risk Proliferative Diabetic Retinopathy.
Status: COMPLETED
Conditions: High Risk Proliferative Diabetic Retinopathy
Interventions: PROCEDURE: Panretinal Photocoagulation (PRP)|DRUG: Intravitreous injection of ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Diagnostic Accuracy Before or After Stricture Dilation in Biliary Stricture
Status: UNKNOWN
Conditions: Biliary Strictures
Interventions: PROCEDURE: Multimodal tissue-sampling methods before and after stricture dilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Methylprednisolone on Endothelial Function in Patients Undergoing Total Knee-arthroplasty
Status: COMPLETED
Conditions: Osteoarthrosis
Interventions: DRUG: Methylprednisolone|DRUG: Isotonic Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Evaluation of Safety and Efficacy of PDP-716
Status: COMPLETED
Conditions: Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Brimonidine Tartrate Ophthalmic Suspension|DRUG: Brimonidine Tartrate Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Effectiveness and Differential Usability of the UP in Spanish University Students
Status: NOT_YET_RECRUITING
Conditions: Emotional Disorder|Depression, Anxiety|Emotion Regulation
Interventions: BEHAVIORAL: Unified Protocol for the transdiagnostic treatment of emotional disorders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Insulin Therapy for the Prevention of New Onset Diabetes After Transplantation Prospective Study in Non-Diabetic De Novo Kidney Transplant Recipients
Status: COMPLETED
Conditions: Hyperglycemia
Interventions: DRUG: Human insulin isophane, Humulin N (Eli Lilly)|DRUG: Standard of care|DRUG: Insulin lispro, Humalog (Eli Lilly) in insulin pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Metastatic Melanoma Who Are Undergoing Surgery for Lymph Node and Tumor Removal
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: gp100 antigen|BIOLOGICAL: tyrosinase peptide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Comparison of Etomidate and Ketamine for Anesthesia Induction in Coronary Artery Bypass Graft Surgery
Status: UNKNOWN
Conditions: Coronary Artery Bypass Surgery
Interventions: DRUG: Ketamine|DRUG: Etomidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of the VytronUS Ablation System for Treatment of Symptomatic Drug-refractory Paroxysmal Atrial Fibrillation
Status: UNKNOWN
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: VytronUS Ablation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of a New Formulation of Insulin Glargine With Lantus® in Japanese Patients With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Insulin glargine new formulation (HOE901)|DRUG: Insulin glargine (HOE901) (Lantus)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Eslicarbazepine Acetate (BIA 2-093) as Adjunctive Therapy for Refractory Partial Seizures
Status: COMPLETED
Conditions: Partial Epilepsy
Interventions: DRUG: 800 mg QD Eslicarbazepine acetate|DRUG: 1200 mg QD Eslicarbazepine acetate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan, Carboplatin, Bevacizumab, and Radiation Therapy in the Treatment of Limited Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Small Cell Lung|Lung Cancer
Interventions: DRUG: irinotecan|DRUG: carboplatin|DRUG: bevacizumab|PROCEDURE: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ERC Via Double-Balloon-Enteroscopy in Patients With Biliodigestive Anastomosis
Status: UNKNOWN
Conditions: Cholangiography
Interventions: PROCEDURE: cholangiography via double-balloon enteroscopy|PROCEDURE: MR cholangiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: MK0518 in the Treatment of HIV-Infected Patients Switched From a Protease Inhibitor Regimen (0518-033)(TERMINATED)
Status: TERMINATED
Conditions: HIV Infection
Interventions: DRUG: Comparator: raltegravir|DRUG: Comparator: placebo|DRUG: Comparator: lopinavir (+) ritonavir|DRUG: Comparator: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Management With Medication Abortion Through 70 Days' Gestation
Status: COMPLETED
Conditions: Abortion in First Trimester
Interventions: DEVICE: high frequency TENS treatment|DEVICE: Sham TENS treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Frameless Fractionated Stereotactic Radiation in Treating Patients With Brain Metastases
Status: COMPLETED
Conditions: Metastatic Malignant Neoplasm in the Brain
Interventions: RADIATION: Frameless Fractionated Stereotactic Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pronator Quadratus Repair After Volar Plating of Distal Radius Fractures
Status: COMPLETED
Conditions: Forearm Pronation Strength Recovery
Interventions: PROCEDURE: Pronator quadratus repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Intervention for the Reduction of Prostate Cancer Disparities Among African Americans
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer Survivor|Partner|Spouse|Stage I Prostate Cancer AJCC v8|Stage II Prostate Cancer AJCC v8|Stage IIA Prostate Cancer AJCC v8|Stage IIB Prostate Cancer AJCC v8|Stage IIC Prostate Cancer AJCC v8|Stage III Prostate Cancer AJCC v8|Stage IIIA Prostate Cancer AJCC v8|Stage IIIB Prostate Cancer AJCC v8|Stage IIIC Prostate Cancer AJCC v8
Interventions: BEHAVIORAL: Exercise Intervention|OTHER: Informational Intervention|OTHER: Informational Intervention|OTHER: Interview|OTHER: Nutritional Assessment|OTHER: Questionnaire Administration|BEHAVIORAL: Telephone-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase IIb One Year Efficacy and Safety Study of S-2367 in Obese Subjects With Reduced Calorie Diet
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: S-2367 Placebo|DRUG: S-2367 800 mg|DRUG: S-2367 1600 mg|OTHER: Reduced Calorie Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Cytotoxicity, Leaching, and Structural Conformation of Clear Aligners
Status: NOT_YET_RECRUITING
Conditions: Malocclusion|Cytotoxicity
Interventions: DEVICE: Invisalign Cleaning Crystals|DEVICE: Fittey Dent Cleaning Tablet|DRUG: Listeren Mouthwash|DEVICE: Toothbrush and Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of a Probiotic Supplement
Status: COMPLETED
Conditions: Gastrointestinal Discomfort
Interventions: DIETARY_SUPPLEMENT: I3.1|DIETARY_SUPPLEMENT: Placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Multicenter Trial of PLA vs. Surgery for Treating PTMC
Status: UNKNOWN
Conditions: Thyroid Cancer|Treatment Related Cancer
Interventions: PROCEDURE: PLA|PROCEDURE: Thyroid Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dupilumab for the Treatment of Chronic Inducible Cold Urticaria in Patients Who Remain Symptomatic Despite the Use of H1-antihistamine (LIBERTY-CINDU CUrIADS)
Status: COMPLETED
Conditions: Cold Urticaria
Interventions: DRUG: Dupilumab SAR231893|DRUG: Placebo|DRUG: Non sedating H1-antihistamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First-in-human Study of DB-1305/BNT325 for Advanced/Metastatic Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: DB-1305/BNT325|COMBINATION_PRODUCT: Pembrolizumab|DRUG: BNT327
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT