pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Trendelenburg Maneuver Versus Passive Leg Raising Test for Fluid Responsiveness in High-Risk Surgical Patients
Status: RECRUITING
Conditions: Trendelenburg Maneuver|Passive Leg Raising|High-Risk Surgical Patients
Interventions: DIAGNOSTIC_TEST: Trendelenburg maneuver (TM)|DIAGNOSTIC_TEST: Passive leg raising test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Systane Hydration in Subjects Undergoing Cataract Surgery
Status: COMPLETED
Conditions: Dry Eye Disease|Cataract
Interventions: OTHER: Systane Hydration lubricant eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Local Infiltration Analgesia During Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Pain
Interventions: DRUG: The injectant mixture consists of 150 mg levobupivacaine mixed with 30 mg ketorolac and 0.5 mg adrenaline|OTHER: saline injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Effect of Hypnosis in Spinal Cord Injury Patients
Status: TERMINATED
Conditions: Spinal Cord Injuries
Interventions: OTHER: Coping-oriented hypnosis|OTHER: Neutral hypnosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and in Vitro Transmission Blocking Activities Study of Primaquine Compare to Methylene Blue in Healthy Volunteer Both G6PD Normal and G6PD Deficiency
Status: COMPLETED
Conditions: G6PD Normal|G6PD Deficient|Healthy
Interventions: DRUG: Regimens (Primaquine, Methylene blue)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Papillomavirus (HPV) Vaccination vs. Placebo for the Treatment of Refractory Cutaneous Warts
Status: RECRUITING
Conditions: Warts
Interventions: BIOLOGICAL: Human Papillomavirus 9-valent Vaccine, Recombinant|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Strain vs. Left Ventricular Ejection Fraction-based Cardiotoxicity Prevention in Breast Cancer
Status: UNKNOWN
Conditions: Cardiotoxicity|Breast Cancer|Prevention|Adjuvant|Trastuzumab
Interventions: DRUG: Candesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination of Trametinib (MEK Inhibitor) and Hydroxychloroquine (HCQ) (Autophagy Inhibitor) in Patients With KRAS Mutation Refractory Bile Tract Carcinoma (BTC).
Status: TERMINATED
Conditions: Bile Duct Cancer|Biliary Cancer|Biliary Tract Neoplasms|Cholangiocarcinoma
Interventions: DRUG: Trametinib|DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduction of Pain Following Laparoscopic Surgery: A Double Blind Prospective Randomized Controlled Trial
Status: COMPLETED
Conditions: Post-operative Pain
Interventions: PROCEDURE: intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Supplemental Oxygen on Maximal Oxygen Consumption in Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Fractional inspired oxygen (FiO2) 0.21|OTHER: Fractional inspired oxygen 0.28
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Phase 1b/II Trial of Pembrolizumab Plus IMRT in Stage III/IV Carcinoma of Anus
Status: UNKNOWN
Conditions: Anal Cancer Stage III A|Anal Cancer Stage III B
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Plasmapheresis or Human Immunoglobulin Infusion in Childhood Guillain-Barre Syndrome
Status: TERMINATED
Conditions: Guillain-Barre Syndrome
Interventions: DRUG: Immune globulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Extension Study to Evaluate the Post-Treatment Safety and Duration of Clinical Effect of LIPO-202
Status: TERMINATED
Conditions: Central Abdominal Bulging
Interventions: DRUG: LIPO-202|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinical Impact of Rapid Identification of Positive Blood Cultures vs. Internal Laboratory Standard
Status: COMPLETED
Conditions: Bloodstream Infections
Interventions: DIAGNOSTIC_TEST: conventional identification method: biochemical profiling or MALDI-TOF MS|DIAGNOSTIC_TEST: new identification method: Biofire FilmArray© BCID panel|DIAGNOSTIC_TEST: new identification method: metagenomic WGS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study of Non-Myeloablative, HLA-Matched Allogeneic Stem Cell Transplantation for Pediatric Hematopoietic Malignancies
Status: COMPLETED
Conditions: Hodgkin Lymphoma|Lymphocytic Leukemia|Mixed Cell Leukemia|Myelodysplastic Syndrome|Non Hodgkin's Lymphoma|CML|ALL|AML|Lymphoma
Interventions: PROCEDURE: Stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Intervention Study to Improve Therapeutic Compliance in Adult Patients With Eosinophilic Esophagitis.
Status: RECRUITING
Conditions: Eosinophilic Esophagitis
Interventions: BEHAVIORAL: Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Efficacy and Safety of Vardenafil Flexible Dose Versus Placebo in Males With Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Levitra (Vardenafil, BAY38-9456)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Erbium-YAG Laser Versus Platelet Rich Plasma in the Treatment of Atrophic Acne Scars
Status: COMPLETED
Conditions: Acne Vulgaris|Scars
Interventions: DEVICE: Fractional Erbium Yağ Laser|PROCEDURE: Platelet Rich Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Estrogen Replacement in Anorexia Nervosa
Status: TERMINATED
Conditions: Anorexia Nervosa
Interventions: DRUG: ethinyl estradiol 0.03mg and dienogest 2 mg (combination)|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Radiographic Outcomes of TLIF w/3D Printed Cellular Implant
Status: RECRUITING
Conditions: Foraminal Stenosis|Degenerative Disc Disease|Lumbar Spondylolisthesis|Lumbar Spinal Stenosis
Interventions: DEVICE: CONDUIT™ Interbody Platform composed of the EIT (Emerging Implant Technologies) Cellular Titanium®
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Two Approaches of Transversus Abdominis Block (TAP ) in Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Opioid Use
Interventions: PROCEDURE: Group A|PROCEDURE: Group B|OTHER: Group C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Fractional CO2 Laser Treatment on Vaginal Symptoms and Sexual Dysfunction in Women With Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis|Vulvovaginal Signs and Symptoms|Sexual Function Disturbances
Interventions: DEVICE: CO2 Vaginal Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Oral Contraceptives or Hormone Replacement Therapy in Women With Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: estradiol|DRUG: ethinyl estradiol|DRUG: medroxyprogesterone|DRUG: norethindrone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of [11C]CPPC to Assess the Safety and Tolerability in Patients With ALS
Status: TERMINATED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: [11C]CPPC Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Temozolomide + Nivolumab in MGMT Methylated Oesophagogastric Cancer
Status: RECRUITING
Conditions: Adenocarcinoma - GEJ|Cancer of Esophagus
Interventions: DRUG: Temozolomide|DRUG: Temozolomide 50mg/m2/day|DRUG: Temozolomide 3 month|DRUG: Temozolomide 24month
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Iferanserin to Treat Hemorrhoids
Status: COMPLETED
Conditions: Hemorrhoids
Interventions: DRUG: Iferanserin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of the Detection of Hypoventilation During Deep Sedation Utilizing Nasal End Title CO@ Versus Transcutaneous CO2 Measurement Techniques
Status: COMPLETED
Conditions: Surgery|Hypoventilation
Interventions: OTHER: Arterial blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy Study of Homeopathic Potassium Dichromate to Treat Tracheal Secretions in Critically Ill Patients
Status: TERMINATED
Conditions: Ventilator Adverse Event
Interventions: DRUG: Homeopathic Potassium Dichromate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of TS-143 in Healthy Adult Male Subjects (Single-Dose Administration)
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: TS-143|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Drug-Drug Interaction of Lopinavir/Ritonavir on Pitavastatin
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Pitavastatin (NK-104)|DRUG: Lopinavir/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Grafting of Autologous Adipose Stromal Cell Trial
Status: UNKNOWN
Conditions: Micromastia
Interventions: PROCEDURE: Adipose Derived Stem Cells|PROCEDURE: SVF Enriched Autologous Fat Grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycemic Response to Low Sugar Apple Juice
Status: COMPLETED
Conditions: Impaired Fasting Glucose
Interventions: OTHER: treated apple juice with low sugar content|OTHER: un-treated apple juice with normal sugar content
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hypothermia During Intracranial Aneurysm Surgery Trial
Status: COMPLETED
Conditions: Aneurysm|Hypothermia|Subarachnoid Hemorrhage
Interventions: PROCEDURE: mild intraoperative hypothermia (33 degrees Celsius)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Anti-VEGF Treatment for Prevention of PDR/DME
Status: COMPLETED
Conditions: Diabetic Retinopathy|Diabetic Macular Edema
Interventions: PROCEDURE: Prompt Sham|DRUG: Prompt aflibercept|PROCEDURE: Deferred laser|DRUG: Deferred aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Manualized Treatment in a Seamless System
Status: COMPLETED
Conditions: Substance Abuse|Offenders|Criminal Thinking|HIV Risk Behaviors
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Blood Sample Markers of Reproductive Hormones in Assessing Ovarian Reserve in Younger Patients With Newly Diagnosed Lymphomas
Status: COMPLETED
Conditions: Anaplastic Large Cell Lymphoma|Burkitt Lymphoma|Diffuse Large B-Cell Lymphoma|Hodgkin Lymphoma|Lymphoma
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Conservative Endometrioma Surgery
Status: RECRUITING
Conditions: Endometriosis Ovary|Endometrioma
Interventions: PROCEDURE: Comparison between 2 different laparoscopic techniques in conservative surgical treatment of endometriomas (both arms are existing and accepted surgical strategies).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabetic Retinopathy Candesartan Trials
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: candesartan cilexetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Direct Anterior Approach (DAA) for Total Hip Arthroplasty (THA): Corail Prosthesis With or Without Collar Design
Status: UNKNOWN
Conditions: Coxarthritis
Interventions: DEVICE: Corail with collar.|DEVICE: Corail without collar.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Efficacy and Safety of the Morning Injection of Toujeo Versus Lantus in Patients With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: HOE901-U300 (Insulin Glargine 300 U/ml)|DRUG: Lantus (Insulin Glargine 100 U/ml)|DRUG: Mandated back ground therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxygen Concentration During Alveolar Recruitment
Status: COMPLETED
Conditions: Atelectasis, Postoperative Pulmonary
Interventions: PROCEDURE: FiO2_1.0|PROCEDURE: FiO2_0.4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Diagnostic Contributions of Nerve Ultrasound in Chronic Inflammatory Demyelinating Polyneuropathy Associating Systemic Diseases (CIDP Echo-nerf)
Status: WITHDRAWN
Conditions: Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Interventions: OTHER: None, pure observationnal study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Modified Pivotal Response Treatment for Insistence on Sameness in Autistic Youth
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Restricted Behavior|Autism
Interventions: BEHAVIORAL: Modified Pivotal Response Treatment for Insistence on Sameness in Autistic Youth
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Single Ascending Dose, Randomized, Double-Blind, Placebo and Positive Controlled Study to Evaluate the Cardiovascular Effect of Tetrodotoxin in Healthy Adult Subjects
Status: COMPLETED
Conditions: TQT Study
Interventions: DRUG: Tetrodotoxin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Using CGM for Evaluating Effects of Food on Glucose Regulation in Healthy Humans
Status: COMPLETED
Conditions: Glycemic Control|Diet, Food and Nutrition
Interventions: DIETARY_SUPPLEMENT: Drinks containing 5AA+CrPic and Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intermittent Oral Tube on Feeding Amount
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: DEVICE: Nasogastric Tube Feeding|DEVICE: Intermittent Oro-esophageal Tube Feeding|BEHAVIORAL: comprehensive rehabilitation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate SHR-1210 in Combination With Famitinib Plus Chemotherapy in Subjects With NSCLC.
Status: UNKNOWN
Conditions: Non-squamous Non-small-cell Lung Cancer
Interventions: DRUG: Camrelizumab;Pemetrexed and Carboplatin; Famitinib;|DRUG: Camrelizumab;Pemetrexed and Carboplatin;Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Cooled Haemodialysis on Cognitive Function in Patients Suffering With End-stage KD
Status: UNKNOWN
Conditions: Cognitive Impairment
Interventions: PROCEDURE: Lower Temperature Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Anti-D for Treating Thrombocytopenia in Adults Infected With Hepatitis C Virus With or Without HIV Co-Infection
Status: TERMINATED
Conditions: Thrombocytopenia|Hepatitis C|HIV Infections
Interventions: DRUG: Anti-D
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azelaic Acid as a Novel Treatment for Central Centrifugal Cicatricial Alopecia (CCCA)
Status: NOT_YET_RECRUITING
Conditions: Central Centrifugal Cicatricial Alopecia
Interventions: DRUG: azelaic acid|OTHER: usual medication for CCCA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Xeloda and Gleevec in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Colon Cancer|Colorectal Cancer
Interventions: DRUG: capecitabine, imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Assess Safety and Immunogenicity of Gam-COVID-Vac Combined Vector Vaccine for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Сov-2) Infection
Status: UNKNOWN
Conditions: COVID-19 Prevention
Interventions: BIOLOGICAL: Gam-COVID-Vac|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of a Paleolithic Based Diet Compared to MyPlate Guidelines, With and Without Exercise, in Women.
Status: COMPLETED
Conditions: Healthy
Interventions: BEHAVIORAL: MyPlate|BEHAVIORAL: MyPlate + Exercise|BEHAVIORAL: Paleolithic|BEHAVIORAL: Paleolithic + Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose:
Clinical trial: NEO- and Adjuvant Targeted Therapy in Braf-mutated Anaplastic Cancer of the Thyroid (NEO-ATACT Study)
Status: RECRUITING
Conditions: Anaplastic Thyroid Cancer
Interventions: DRUG: dabrafenib/trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Adverse Events and Change in Disease Activity of JUVÉDERM® VOLITE™ XC Injectable Gel for Change in Neck Appearance in Adult Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Neck Lines
Interventions: DEVICE: VOLITE XC|DEVICE: VOLITE XC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Detection of BRAF Mutation on FNAB From Papillary Thyroid Carcinoma
Status: COMPLETED
Conditions: Papillary Thyroid Carcinoma
Interventions: OTHER: BRAF detection on fine needle aspiration biopsy (FNAB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Use of Prokinetics During Inpatient Bowel Care for SCI Patients
Status: UNKNOWN
Conditions: Spinal Cord Injury|Neurogenic Bowel
Interventions: DRUG: Intravenous Neostigmine and Glycopyrrolate|DRUG: Transdermal Neostigmine and Glycopyrrolate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Non-surgical Periodontal Therapy on Severe Periodontitis and Hyperlipidemia
Status: UNKNOWN
Conditions: Periodontitis Chronic Generalized Severe|Hyperlipidemia|Gingival Crevicular Fluid|Serum|Biomarkers|Non-surgical Periodontal Therapy
Interventions: PROCEDURE: non-surgical periodontal therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Efficacy of Everolimus With Reduced-dose Tacrolimus Versus Reduced-dose Tacrolimus in Treatment of BK Virus Infection in Kidney Transplantation Recipient
Status: RECRUITING
Conditions: Kidney Transplant Infection|BK Virus Infection
Interventions: DRUG: Everolimus|DRUG: reduced dose tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quadriceps Strengthening With Patellar Taping in Patellofemoral Pain Syndrome Among Young Adult Male Athletes
Status: COMPLETED
Conditions: Patellofemoral Disorder|Anterior Knee Pain
Interventions: BEHAVIORAL: Electromyography biofeedback (EMG-BF)|BEHAVIORAL: Sham electromyography biofeedback (EMG-BF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A French Protocol for the Treatment of Acute Lymphoblastic Leukemia (ALL) in Children and Adolescents
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: pegaspargase 1250 IU/m2 x 2|DRUG: pegaspargase 2500 IU/m2 x 1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weight Gain in Extremely Premature Infant With Targeted Versus Adjusted Fortification
Status: COMPLETED
Conditions: Preterm|Very Low Birth Weight Infant|Feeding, Breast|Food, Fortified
Interventions: DIETARY_SUPPLEMENT: Protein supplementation based on plasma urea concentration every other week or human milk analysis on experiment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The END Perioperative Smoking Pilot Study
Status: COMPLETED
Conditions: Smoking|Nicotine Addiction|Surgery
Interventions: BEHAVIORAL: ENDD (NJOY)|DRUG: NRT (NicoDerm CQ)|BEHAVIORAL: telephone counseling|BEHAVIORAL: brief advice|BEHAVIORAL: brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glucagon Like Peptides Receptors Expression in the Stomach of Diabetes Type 2
Status: UNKNOWN
Conditions: Diabetes Mellitus Type 2
Interventions: PROCEDURE: GLP receptors expression|PROCEDURE: ESOPHAGOGASTRODUODENOSCOPY
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rate Control Efficacy in Atrial Fibrillation With Rheumatic Mitral Stenosis: Lenient vs Strict Rate Control Strategies
Status: RECRUITING
Conditions: Atrial Fibrillation|Rheumatic Mitral Stenosis|Arrhythmias, Cardiac
Interventions: OTHER: Rate control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FDG-Labeled PET Scan in Planning Chemotherapy in Treating Patients With Stage IIIB or IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Malignant Pleural Effusion|Stage IIIB Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: DRUG: carboplatin|DRUG: docetaxel|DRUG: gemcitabine hydrochloride|DRUG: paclitaxel|PROCEDURE: computed tomography|PROCEDURE: positron emission tomography|RADIATION: fludeoxyglucose F 18|OTHER: imaging biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hepatic Impairment Study for Lorlatinib in Cancer Patients
Status: TERMINATED
Conditions: Advanced Cancers
Interventions: DRUG: lorlatinib|DRUG: lorlatinib|DRUG: lorlatinib|DRUG: lorlatinib|DRUG: lorlatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Active Immunotherapy With GRNVAC1 in Patients With Acute Myelogenous Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia
Interventions: BIOLOGICAL: GRNVAC1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-VEGF in Real-world
Status: UNKNOWN
Conditions: Neovascular Age-related Macular Edema|Diabetic Macular Edema|Choroidal Neovascular Membrane|Non-proliferative Diabetic Retinopathy|Retinal Vein Occlusion|Proliferative Diabetic Retinopathy
Interventions: DRUG: Ranibizumab|DRUG: Aflibercept|DRUG: Conbercept
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Effect of Elix Cycle Balance and Daily Harmony on Polycystic Ovary Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Polycystic Ovary Syndrome
Interventions: OTHER: Elix Daily Harmony|OTHER: Elix Cycle Balance
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy Study Evaluating TRx0237 in Subjects With Mild Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: TRx0237 200 mg/day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Serplulimab Combined With Anti-VEGF Antibody in Advanced Lung Adenocarcinoma
Status: NOT_YET_RECRUITING
Conditions: Lung Adenocarcinoma|Stage IV Non-small Cell Lung Cancer|PD-1 Inhibitor|VEGF
Interventions: DRUG: Serplulimab and Bevacizumab injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Advises Sent Via Email in Attempt of Improving A1C in DM2 Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: web-based DM2 information pages
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ASSESSMENT OF SOFT TISSUE HEALING OVER IMMEDIATELY PLACED IMPLANT SEALED WITH PLATELETS RICH FIBRIN (PRF) VERSUS DIODE LASER
Status: COMPLETED
Conditions: Immediate Implant Soft Tissue Healing
Interventions: BIOLOGICAL: Platelet Rich Fibrin|DEVICE: Diode laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nd:YAG Laser and Radiofrequency in Treatment of Fingernail Psoriasis
Status: NOT_YET_RECRUITING
Conditions: Nail Psoriasis
Interventions: DEVICE: Radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Processing Speed and Executive Functioning in Depressed Older Adults With Computerized Cognitive Training
Status: WITHDRAWN
Conditions: Depression in Old Age|Depression
Interventions: OTHER: Experimental: Computerized Cognitive Training|DRUG: Experimental: Open-label antidepressant treatment|OTHER: Active Comparator: Solitaire Training|OTHER: Placebo Comparator: Placebo-controlled antidepressant treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Dose Morphine to Relieve Dyspnea in Acute Respiratory Failure (OPIDYS)
Status: COMPLETED
Conditions: Acute Respiratory Failure
Interventions: DRUG: Chlorhydrate de morphine|DRUG: NaCl 0,9%,
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Safety, Tolerability and Pharmacokinetics of Single Doses of AZD8566.
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: AZD8566|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: EU SolidAct: An Adaptive Pandemic and Emerging Infection Platform Trial
Status: TERMINATED
Conditions: COVID-19|Emerging Infectious Disease
Interventions: DRUG: Baricitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Collagen-Silver Versus Standard Care Following Removal of Ingrown Nails
Status: UNKNOWN
Conditions: Ingrown Nail
Interventions: DEVICE: oxidized regenerated cellulose collagen-silver|DRUG: topical silver sulfadiazine cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Studies of Gemcitabine-Oxaliplatin
Status: COMPLETED
Conditions: Medulloblastoma|Central Nervous System Tumors|Neuroblastoma|Osteosarcoma
Interventions: DRUG: Gemcitabine (Gemzar®), Oxaliplatin (Eloxatin®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Valve Hemodynamic Optimization Based on Doppler-Echocardiography vs Catheterization Measurements Following ViV TAVR
Status: RECRUITING
Conditions: Aortic Valve Stenosis|Aortic Valve Regurgitation|Prosthesis Failure
Interventions: PROCEDURE: Doppler-echocardiography|PROCEDURE: Invasive hemodynamic measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Total Shoulder Arthroplasty Preoperative Pain Threshold and Association With Postoperative Opioid Consumption
Status: ENROLLING_BY_INVITATION
Conditions: Total Shoulder Arthroplasty|Postoperative Pain|Opioid Use
Interventions: DEVICE: Pain Threshold using algometer/dolorimeter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Integrated Treatment to Persons With Mental Disorders and Co-occurring Substance Use Disorders
Status: COMPLETED
Conditions: Anxiety Disorders|Mood Disorders|Substance Use Disorders
Interventions: BEHAVIORAL: Integrated mental health and substance use treatment|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiorespiratory Responses to a Pilates Training Session and Treadmill Walking in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: BEHAVIORAL: Pilates exercise session|BEHAVIORAL: Treadmill walking at 3.2 kph|BEHAVIORAL: Treadmill walking at 4.8 kph
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of MCT Oil for Enhancement of Weight Loss and Glycemic Control in Obese Diabetic Patients
Status: COMPLETED
Conditions: Obesity|Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: MCT oil hypocaloric liquid diet|BEHAVIORAL: LCT hypocaloric liquid diet|PROCEDURE: Subcutaneous abdominal adipose tissue biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-arterial Gemcitabine vs. IV Gemcitabine and Nab-Paclitaxel Following Radiotherapy for LAPC
Status: RECRUITING
Conditions: Locally Advanced Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: nab-paclitaxel|DEVICE: RenovoCath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetics (PK) Study in Lice Infested Children 6 Months to 3 Years of Age
Status: COMPLETED
Conditions: Head Lice
Interventions: DRUG: 0.5% Ivermectin Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation Study of mHealth Technology in HIV to Improve Empowerment and Healthcare Utilisation: Research and Innovation to Generate Evidence for Personalised Care (EmERGE)
Status: UNKNOWN
Conditions: HIV Infections
Interventions: OTHER: mHealth platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Exploration of Allograft Humoral Rejection in Chronic Histiocytic Intervillositis
Status: NOT_YET_RECRUITING
Conditions: Chronic Histiocytic Intervillositis|Intrauterine Growth Retardation|Fetal Death in Utero|Miscarriage
Interventions: PROCEDURE: Biological collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Post Market Clinical Follow up Evaluating the Performance and Safety of Juläine(TM) on Nasolabial Fold Wrinkles
Status: RECRUITING
Conditions: Nasolabial Fold
Interventions: DEVICE: Juläine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Novel Posttraumatic Stress Disorder Treatment for Veterans With Moral Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Moral Injury
Interventions: BEHAVIORAL: Impact of Killing (IOK)|BEHAVIORAL: Present Centered Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Impact of the Early and Systematic Hormonal Replacement After Radio-isotopic Ablation of Graves'hyperthyroïdism on Quality of Life, Efficiency and Tolerance
Status: COMPLETED
Conditions: Graves Disease (Basedow's Disease)
Interventions: DRUG: the early prophylactic introduction of low dose of LT4 (50 µg/d) at 15 days post-ablation|DRUG: The initiation of LT4 as soon as the first biological signs of hypothyroidism.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prospective Randomized Trial of Irritative Symptoms Severity Assessment After (HoLEP) Versus ThuFLEP
Status: UNKNOWN
Conditions: BPH|Prostate Obstruction
Interventions: PROCEDURE: Thulium fiber laser enucleation of the prostate|PROCEDURE: Holmium laser enucleation of the prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Optimal Management of Malignant Dysphagia
Status: TERMINATED
Conditions: Malignant Dysphagia|Esophageal Cancer
Interventions: RADIATION: Brachytherapy|PROCEDURE: Stent insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acute Effects of Beet Extract on Autonomic and Cardiovascular Recovery After Exercise
Status: COMPLETED
Conditions: Cardiovascular Diseases|Prevention
Interventions: DIETARY_SUPPLEMENT: Beetroot extract|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Sildenafil Administration to Treat Neonatal Encephalopathy
Status: COMPLETED
Conditions: Neonatal Encephalopathy
Interventions: DRUG: Sildenafil|DRUG: Ora-Blend
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Plus Bevacizumab in Locally Recurrent or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Locally Advanced Breast Cancer
Interventions: DRUG: Gemcitabine|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Boost rTMS for Auditory Verbal Hallucinations
Status: TERMINATED
Conditions: Schizophrenia|Auditory Hallucination
Interventions: DEVICE: transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implant-based Breast Reconstruction and Mastectomy With Fat Grafting After Breast Conserving Surgery and Radiotherapy
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: Immediate tissue expander and lipofilling after mastectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, PK, Anti-Tumor Activity of STP705 in Subjects With Advanced/Metastatic or Surgically Unresectable Solid Tumors Who Are Refractory to Standard Therapy
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Liver Metastases|Cholangiocarcinoma
Interventions: DRUG: STP705
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Intra-articular Corticosteroid Injection to Treat Osteoarthritis of the Carpometacarpal Joint
Status: RECRUITING
Conditions: Osteoarthritis of the Carpometacarpal Joint|Thumb Osteoarthritis
Interventions: DRUG: Depo-Medrol Injectable Product|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Local Anesthesia Versus Combined Local Anesthesia With Single Dose Analgesia on Pain Control During Thoracic Ultrasound Guided Procedures
Status: UNKNOWN
Conditions: Pleural Neoplasms|Aspiration, Respiratory|Pleural Effusion|Lung Neoplasms|Pneumothorax|Pyothorax
Interventions: DRUG: Diclofenac|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Remifentanil in Deep vs Moderate Neuromuscular Blocks During Surgical Pleth Index-guided Anesthesia for Laparoscopic Herniorrhaphy
Status: COMPLETED
Conditions: Hernia Abdominal Wall
Interventions: DRUG: Moderate neuromuscular block|DRUG: Deep neuromuscular block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CD7 CAR-T in the Treatment of CD7 Positive Refractory Relapsed Acute Leukemia
Status: UNKNOWN
Conditions: T-ALL
Interventions: DRUG: T cell injection targeting CD7 chimeric antigen receptor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral Lactobacillus Plantarum GUANKE (CGMCC NO.21720) in Enhancement of Antibody Level After SARS-CoV-2 Vaccination (Trial 1)
Status: COMPLETED
Conditions: SARS-CoV-2
Interventions: DIETARY_SUPPLEMENT: Probiotics daily|DIETARY_SUPPLEMENT: Placebo daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Gynostemma Pentaphyllum(Dungkulcha) Extract on Alleviation of Chronic Stress-induced Strain
Status: COMPLETED
Conditions: Chronic Stress-Induced Strain
Interventions: DIETARY_SUPPLEMENT: Gynostemma Pentaphyllum(Dungkulcha) Extract(400mg/day)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety and Efficacy of CBP-201 in Chinese Adult Subjects With Moderate to Severe AD
Status: ACTIVE_NOT_RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: CBP-201
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Saquinavir and Zalcitabine, Used Alone and Together, in the Treatment of Advanced HIV Infection in Patients Who Stopped Taking or Who Cannot Take Zidovudine
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Saquinavir|DRUG: Zalcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Transarterial Chemoembolization for the Treatment of Uveal Melanoma With Liver Metastases
Status: RECRUITING
Conditions: Metastatic Malignant Neoplasm in the Liver|Metastatic Uveal Melanoma|Stage IV Choroidal and Ciliary Body Melanoma AJCC V8
Interventions: DRUG: Carmustine|DRUG: Ethiodized Oil|PROCEDURE: Transarterial Chemoembolization|OTHER: Medical Device Usage and Evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Need for Breathing Retraining: the Elephant in the Cardiac Rehabilitation Room
Status: COMPLETED
Conditions: Chronic Heart Failure
Interventions: BEHAVIORAL: Cardiac rehabilitation with breathing retraining|BEHAVIORAL: Cardiac rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Allopurinol and Febuxostat on Urinary 2,8-Dihydroxyadenine Excretion
Status: COMPLETED
Conditions: Adenine Phosphoribosyltransferase Deficiency
Interventions: DRUG: Allopurinol|DRUG: Febuxostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Trial of Oxytocin in Adolescents With Autism Spectrum Disorders
Status: COMPLETED
Conditions: Autism Spectrum Disorders|Pervasive Developmental Disorders|ASD|PDD
Interventions: DRUG: Intranasal Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Gemzar®, Taxotere®, and Xeloda® (GTX) in Patients With Metastatic Pancreatic Cancer (Stage IVB)
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Gemcitabine, Docetaxel, Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Protein Diet on Transcriptomic, Metabolomics, Hepatic and Pancreatic Fat Anatomy and Physiology in Asian Indians With Pre-diabetes
Status: NOT_YET_RECRUITING
Conditions: Pre-diabetes
Interventions: OTHER: Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: CSF1R PET Probe [18F]CSF-23 in Alzheimer's Disease Brain Imaging
Status: RECRUITING
Conditions: Positron Emission Tomography|Alzheimer Disease|Neurodegenerative Diseases
Interventions: RADIATION: [18F]CSF-23
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase 2 to Assess Efficacy and Safety in AR882 Alone or in Combination With Allopurinol in Patients With Tophaceous Gout
Status: ACTIVE_NOT_RECRUITING
Conditions: Gout|Arthritis, Gouty|Hyperuricemia|Gout Chronic
Interventions: DRUG: AR882 Dose 1|DRUG: AR882 Dose 2|DRUG: Allopurinol Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture in the Emergency Department for Pain Management
Status: ACTIVE_NOT_RECRUITING
Conditions: Acupuncture|Pain Management|Emergency Department|Acute Pain
Interventions: PROCEDURE: Acupuncture for pain management|OTHER: Usual care for pain management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER