pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Propranolol to Decrease Gene Expression of Stress-Mediated Beta-Adrenergic Pathways in HCT Recipients
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Propranolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Viral Response to Triple Therapy in Hepatitis C Virus-Infected Participants With Insulin Resistance Who Failed Dual Therapy (MK-3034-113)
Status: WITHDRAWN
Conditions: Hepatitis C
Interventions: DRUG: boceprevir|BIOLOGICAL: PegIFN-2b|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-operative Complications and Graft Survival With Conventional Versus Continuous Glucose Monitoring in Patients With Diabetes Mellitus Undergoing Renal Transplantation
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: Continuous Glucose Monitor Application|DIAGNOSTIC_TEST: Finger Stick Glucose Measurement|DRUG: Insulin|DEVICE: Continuous Glucose Monitor Placebo Applied
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A New Intervention to Improve Function in Veterans With Anxiety and Depression
Status: NOT_YET_RECRUITING
Conditions: Anxiety and Depression
Interventions: DRUG: Pregnenolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Abbreviated MRI for HCC Surveillance
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma|Liver Cirrhosis|Chronic Hepatitis
Interventions: DIAGNOSTIC_TEST: Biannual ultrasonography|DIAGNOSTIC_TEST: Annual abbreviated liver MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Randomized Trial of Narcotic vs Non-Narcotic Pain Modulation After Labrum Repair
Status: ENROLLING_BY_INVITATION
Conditions: Postoperative Pain, Acute|Opioid Use|Labral Tear, Glenoid
Interventions: DRUG: Tylenol, Ibuprofen, and Oxycodone|DRUG: Tylenol and Ibuprofen only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Patient-Centered Decision App on TOLAC
Status: COMPLETED
Conditions: Pregnancy|Repeat Cesarean Section|Vaginal Births After Cesarean
Interventions: BEHAVIORAL: Prior CD Decision App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact of CCR5 Blockade in HIV+ Kidney Transplant Recipients
Status: COMPLETED
Conditions: HIV Infections|Kidney Diseases
Interventions: DRUG: Maraviroc|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluorescence Imaging of Adalimumab-680LT in Inflammatory Bowel Disease
Status: RECRUITING
Conditions: Crohn Disease|Ulcerative Colitis
Interventions: DRUG: Adalimumab-680LT|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase IV Study to Assess the Impact of the Change of Antiretroviral Treatment From Dual Therapy to Triple Therapy on Inflammation in Patients With HIV Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Dual Therapy|DRUG: Triple therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patients With Metastatic Colorectal Cancer Treated With Regorafenib or Placebo After Failure of Standard Therapy
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Regorafenib (Stivarga, BAY73-4506)|DRUG: Placebo|OTHER: Best Supportive Care (BSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Prolonged Postoperative Antibiotics Administration on Rate of Infection in Patients Undergoing Posterior Spine Surgery Requiring a Hemovac Drain
Status: COMPLETED
Conditions: Postoperative Infection
Interventions: DRUG: Antibiotic|DRUG: Antibiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: IMPACT (Improving Plasma Collection) Clinical Trial
Status: COMPLETED
Conditions: Apheresis Related Hypotension
Interventions: DEVICE: Updated Plasma Collection Feature|DEVICE: Current Plasma Collection Approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparative Effect of MEP With or Without Current Emission in the Treatment of Cervical Pain in MTrPs of the Trapezius
Status: COMPLETED
Conditions: Neck Pain, Posterior|Myofascial Pain Syndromes
Interventions: OTHER: percutaneous microelectrolysis in myofascial trigger points of the trapezius
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: MDCO-216 Infusions Leading to Changes in Atherosclerosis: A Novel Therapy in Development to Improve Cardiovascular Outcomes - Proof of Concept Intravascular Ultrasound (IVUS), Lipids, and Other Surrogate Biomarkers Trial
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: MDCO-216|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Breathwork Practice (SKY) on Well-Being of Individuals With Parkinson's Disease (iPD) and Care Partners
Status: NOT_YET_RECRUITING
Conditions: Parkinson's Disease
Interventions: BEHAVIORAL: SKY Breath and Meditation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluate the Efficacy and Safety of Large-Scale Field-Directed Topical Therapy of Actinic Keratosis of the Chest w/Ingenol Mebutate 0.015%
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Inggenol Mebutate 0.015%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: XELOX Combined With Fruquintinib and Sintilimab Regimen Conversion Therapy for Gastric Cancer/Gastroesophageal Junction Adenocarcinoma Only With Liver and/or Retroperitoneal Lymph Node Metastasis, a Prospective Single-arm, Multicenter Study
Status: RECRUITING
Conditions: Gastric Cancer/Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: XELOX combined with Fruquintinib and Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expiratory Flow Limitation and Mechanical Ventilation During Cardiopulmonary Bypass in Cardiac Surgery
Status: UNKNOWN
Conditions: Mitral Regurgitation|Aortic Regurgitation
Interventions: PROCEDURE: Use of PEEP before and after CPB|PROCEDURE: No use of PEEP before and after CPB(ZEEP)|PROCEDURE: Ventilation with CPAP during CPB|PROCEDURE: No ventilation during CPB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Intravitreal Methotrexate and R2(Rituximab & Lenalidomide) Regimen in Newly-diagnosed Primary Vitreoretinal Lymphoma
Status: RECRUITING
Conditions: Primary Intraocular Lymphoma
Interventions: DRUG: Methotrexate|DRUG: Rituximab|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Umbilical Cord-Mesenchymal Stem Cells for Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: hUC-MSC + DMARDs|DRUG: DMARDs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BAriaTric Surgery After Breast Cancer Treatment (BATS)
Status: NOT_YET_RECRUITING
Conditions: Early-stage Breast Cancer|Obesity
Interventions: PROCEDURE: Bariatric Surgery with Sleeve Gastrectomy|BEHAVIORAL: Lifestyle Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Surgical Education Culture Optimization Through Targeted Interventions Based on National Comparative Data - "The SECOND Trial"
Status: ACTIVE_NOT_RECRUITING
Conditions: Surgical Residency|Workplace Culture|Mistreatment|Burnout
Interventions: OTHER: Resource allocation to improve surgical learning environments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Chinese Herbal Medicine as an Adjuvant Therapy in the Treatment of Traumatic Anosmia
Status: COMPLETED
Conditions: Traumatic Anosmia
Interventions: DRUG: tailored Guizhi decoction|BEHAVIORAL: Olfactory training (OT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Muscle Relaxation in Myopathies With Positive Muscle Phenomena
Status: UNKNOWN
Conditions: Nemaline Myopathy Type 6|Myotonic Dystrophy Type 2|McArdle Disease
Interventions: DIAGNOSTIC_TEST: Transcranial magnetic stimulation (TMS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Post-traumatic Occipital Neuralgia - Surgical Versus Medical Management
Status: WITHDRAWN
Conditions: Post-Traumatic Neuralgia|Occipital Neuralgia
Interventions: PROCEDURE: Occipital neurolysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of CBTi and Usual Treatment for Tinnitus Related Insomnia
Status: UNKNOWN
Conditions: Tinnitus|Insomnia
Interventions: BEHAVIORAL: Cognitive Behaviour Therapy for Insomnia|BEHAVIORAL: Standard Audiological Care|BEHAVIORAL: Sleep Support Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The SleepWell Study - Chronotherapeutic Intervention to Improve Sleep Following ACS
Status: COMPLETED
Conditions: Sleep Disturbance|Insomnia|Acute Coronary Syndrome
Interventions: BEHAVIORAL: BLT Intervention|BEHAVIORAL: BLB Intervention|BEHAVIORAL: Sleep Hygiene Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Curcumin and Cholecalciferol in Treating Patients With Previously Untreated Stage 0-II Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Contiguous Stage II Small Lymphocytic Lymphoma|Noncontiguous Stage II Small Lymphocytic Lymphoma|Stage 0 Chronic Lymphocytic Leukemia|Stage I Chronic Lymphocytic Leukemia|Stage I Small Lymphocytic Lymphoma|Stage II Chronic Lymphocytic Leukemia
Interventions: DRUG: curcumin|DIETARY_SUPPLEMENT: cholecalciferol|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expanded Cord Blood Cell Infusion Following Combination Chemotherapy in Younger Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Leukemia of Ambiguous Lineage|Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Ex-Vivo Expanded Cord Blood Progenitor Cell Infusion|DRUG: Cytarabine|DRUG: Filgrastim|DRUG: Fludarabine Phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Combined ACT+ App Intervention to Improve Psychological Flexibility and Associated Symptoms in Cancer Patients
Status: RECRUITING
Conditions: Cancer
Interventions: BEHAVIORAL: Acceptance and commitment therapy + app|BEHAVIORAL: Acceptance and commitment therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Atorvastatin Calcium Tablets, 80 mg of Dr. Reddy's Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Atorvastatin Calcium Tablets, 80 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Immunogenicity of UB-221 in Healthy Volunteers
Status: NOT_YET_RECRUITING
Conditions: Chronic Spontaneous Urticaria
Interventions: BIOLOGICAL: UB-221
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Snail Slime and Natural Extracts for Healing in Diabetic Foot Ulcers
Status: UNKNOWN
Conditions: Diabetic Foot Ulcer
Interventions: DRUG: MU001 patches (Investigational)|DEVICE: Conventional patches (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sustained Lung Inflation With CPAP in Preterm Neonates (SI-CPAP)
Status: COMPLETED
Conditions: RDS of Prematurity
Interventions: PROCEDURE: Sustained lung inflation|PROCEDURE: Continuous positive airway pressure (CPAP)|PROCEDURE: Mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer
Status: RECRUITING
Conditions: Head and Neck Cancer|Head Cancer|Head Cancer Neck|Neck Cancer|Head and Neck Squamous Cell Carcinoma|HNSCC
Interventions: DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Docetaxel|DRUG: Cetuximab|DRUG: Cemiplimab|PROCEDURE: Surgical Resection of Primary +/- Neck Dissection|RADIATION: Post-operative radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Combination Therapies With Oseltamivir & Zanamivir or Oseltamivir & Amantadine Versus Oseltamivir Monotherapy in the Treatment of Seasonal Influenza A Infection
Status: TERMINATED
Conditions: Influenza A Infection
Interventions: DRUG: oseltamivir + zanamivir|DRUG: oseltamivir+ amantadine|DRUG: oseltamivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conception of a Decisional Tool Using a Pre-Anesthesic Numerical Evaluation (PANE) During the 8th Month of Pregnancy
Status: UNKNOWN
Conditions: Pregnancy Related
Interventions: OTHER: Pre-Anesthesic Consultation|OTHER: Pre-Anesthesic Numerical Evaluation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Avelumab in Third-Line Gastric Cancer (JAVELIN Gastric 300)
Status: COMPLETED
Conditions: Unresectable, Recurrent, Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma|Gastric Cancer Third Line
Interventions: DRUG: Avelumab|DRUG: Irinotecan|DRUG: Paclitaxel|OTHER: Best Supportive Care (BSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety Study of Open-label Pramipexole Extended Release (ER) in Patients With Early Parkinson´s Disease (PD).
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Placebo|DRUG: Pramipexole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trametinib With or Without GSK2141795 in Treating Patients With Metastatic Uveal Melanoma
Status: COMPLETED
Conditions: Recurrent Uveal Melanoma|Stage IV Uveal Melanoma AJCC v7
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Trametinib|DRUG: Uprosertib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Antithrombotic TherApy in Patients With Atrial Fibrillation or DevelOping AtRial Fibrillation During Hospitalization for PCI
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Atrial Fibrillation
Interventions: OTHER: Acute coronary syndrome and PCI and AF
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intrathecal Transplantation of UC-MSC in Patients With Early Stage of Chronic Spinal Cord Injury
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: DRUG: Umbilical Cord Mesenchymal Stem Cells|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Saline Irrigation After Surgery in Patients With Chronic Sinusitis
Status: COMPLETED
Conditions: Chronic Rhinosinusitis
Interventions: DEVICE: NeilMed sinus rinse|DEVICE: Salinex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Genetic Analysis in Diagnosing Thyroid Cancer in Patients With Thyroid Nodules
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: GENETIC: gene expression analysis|GENETIC: polymerase chain reaction|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: diagnostic laboratory biomarker analysis|OTHER: immunohistochemistry staining method|PROCEDURE: needle biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cryoablation+Ipilimumab+Nivolumab in Melanoma
Status: RECRUITING
Conditions: Metastatic Melanoma|Skin Cancer
Interventions: DRUG: Ipilimumab|DRUG: Nivolumab|PROCEDURE: Cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicentre Clinical Study to Evaluate the Effect of Personalized Therapy on Patients With Immunoglobulin A Nephropathy.
Status: RECRUITING
Conditions: Glomerulonephritis|Immunoglobulin A Nephropathy
Interventions: DRUG: Corticosteroid|DRUG: Renin-angiotensin sytem blockers|DRUG: Sodium-glucose cotransporter 2 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detecting Neonatal Hypoglycemia Using Real-Time Continuous Glucose Monitoring (CGM)
Status: COMPLETED
Conditions: Neonatal Hypoglycemia
Interventions: DIAGNOSTIC_TEST: Standard of care glucose test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: High-Flow Needleless Valve and DualCap Disinfection Devices Associate With Catheter-related Bloodstream Infection
Status: UNKNOWN
Conditions: Catheter-related Bloodstream Infection
Interventions: DEVICE: High-Flow Needleless Valve|DEVICE: DualCap Disinfection Devices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial Evaluating the Combination of Vandetanib and Dasatinib During and After Radiation Therapy (RT) in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG)
Status: COMPLETED
Conditions: Diffuse Intrinsic Pontine Glioma
Interventions: DRUG: vandetanib and dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MK-3655 in Individuals With Pre-cirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-3655-001)
Status: TERMINATED
Conditions: Nonalcoholic Steatohepatitis
Interventions: DRUG: MK-3655|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability, and Dermal Reactogenicity Study of PDC-APB
Status: UNKNOWN
Conditions: Contact Dermatitis
Interventions: DRUG: PDC-APB|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of LEO 80185 Gel in Adolescent Subjects (Aged 12 to 17) With Scalp Psoriasis
Status: COMPLETED
Conditions: Scalp Psoriasis
Interventions: DRUG: LEO 80185 (Xamiol® gel/Taclonex® Scalp topical suspension)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Peptide Receptor Radionuclide Therapy With PARP Inhibitors
Status: RECRUITING
Conditions: Neuroendocrine Tumors|Peptide Receptor Radionuclide Therapy
Interventions: DRUG: olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dabrafenib and Lapatinib in Treating Patients With Refractory Thyroid Cancer That Cannot Be Removed by Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Thyroid Gland Carcinoma|Unresectable Thyroid Gland Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Dabrafenib|DRUG: Dabrafenib Mesylate|PROCEDURE: Echocardiography|DRUG: Lapatinib|DRUG: Lapatinib Ditosylate|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Multigated Acquisition Scan|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Negative Ion Generation Versus Light-Emitting Diode Phototherapy for Seasonal Affective Disorder (SAD)
Status: COMPLETED
Conditions: Seasonal Affective Disorder
Interventions: DEVICE: Negative Ion Generator|DEVICE: Light-emitting Photodiode light treatment device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LVIS™ Evo™ and HydroCoil® Embolic System for Intracranial Aneurysm Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Intracranial Aneurysm
Interventions: DEVICE: LVIS EVO and HydroCoil Embolic System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety Study of Oral Pirfenidone in Patients With Pulmonary Fibrosis/Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis|Pulmonary Fibrosis
Interventions: DRUG: Pirfenidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Functional Outcomes Following Ankle Fracture Fixation With or Without Ankle Arthroscopy
Status: NOT_YET_RECRUITING
Conditions: Ankle Fractures|Ankle Injuries|Arthroscopic Surgery
Interventions: PROCEDURE: ankle arthroscopy with ORIF|PROCEDURE: fracture ankle fixation without ankle arthroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peri Tonsillar Infiltration of Ketamine or Bupivacaine for Post Tonsillectomy Analgesia
Status: COMPLETED
Conditions: Post Operative Pain
Interventions: DRUG: Ketamine.|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Investigating the Effect of Floradapt Mature Immune Defense on Nutrient Uptake and Digestive Health in a Healthy Elderly Population
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Floradapt Mature Immune Defense + Multivitamin|DIETARY_SUPPLEMENT: Placebo + Multivitamin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Randomized, Double-blinded, Self-controlled Clinical Study of Intralesional Injection of 5-fluorouracil Plus Triamcinolone for the Treatment of Refractory Nodular Prurigo
Status: NOT_YET_RECRUITING
Conditions: Nodular Prurigo
Interventions: DRUG: 5-fluorouracil Injection|DRUG: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Satisfaction and Retention in Implant Supported Telescopic Overdenture With Different Copings
Status: UNKNOWN
Conditions: Implant Supported Telescopic Overdenture
Interventions: PROCEDURE: Implant placemet in the mandibular canine regions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Training the Arm and Hand After Stroke Using Auditory Rhythm Cues
Status: COMPLETED
Conditions: Stroke|Hemiplegia
Interventions: BEHAVIORAL: Constraint-Induced Movement Therapy + auditory rhythm cues|BEHAVIORAL: Constraint-Induced Movement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Efficacy of Lacosamide Versus Placebo (a Pill Without Active Medication) in Patients With Idiopathic Generalised Epilepsy Who Are Already Taking Anti-epileptic Medications
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Lacosamide Tablet|DRUG: Lasosamide Oral Solution|OTHER: Placebo Tablet|OTHER: Placebo Oral Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Digitalized Differential Diagnosis Broadening in Emergency Rooms
Status: COMPLETED
Conditions: Emergencies|Diagnoses Disease
Interventions: DEVICE: Isabel Pro - The DDx generator (CDDS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Double Blind Placebo Controlled Study on the Effect of Extracorporal Shock Wave Therapy on Erectile Dysfunction in PDE5i Responders
Status: UNKNOWN
Conditions: Erectile Dysfunction
Interventions: DEVICE: "MEDISPEC" treatment probe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tobacco Assessment and Intervention With Low-Income Persons Living With HIV-AIDS (PLWHA) in Community-Based AIDS Service Organizations
Status: COMPLETED
Conditions: Tobacco Cessation|HIV|AIDS
Interventions: BEHAVIORAL: Treatment as usual|BEHAVIORAL: AIR (Aspirations, Inspiration, Respiration)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate The Effect Of Sertraline on the Cardiac Repolarization in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Sertraline|DRUG: Moxifloxacin|DRUG: Drug - Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: MASLD in Primary Hypothyroidism and Efficacy of Dapaglifozin
Status: NOT_YET_RECRUITING
Conditions: Hepatic Steato-Fibrosis|Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: Dapagliflozin 10mg Tab|DRUG: Placebo|DRUG: Levothyroxine Replacement daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Shock Wave Therapy: Do the External Appearance of the Device Influence Clinical Outcomes?
Status: COMPLETED
Conditions: Plantar Fasciitis|Pain
Interventions: DEVICE: Standard shock waves device|DEVICE: Austere shock waves device|DEVICE: Sophisticated shock waves device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nicotine and Pavlovian Bias
Status: RECRUITING
Conditions: Nicotine Vaping|Nicotine Dependence
Interventions: DRUG: Nicotine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: SurgiMend® vs. Strattice™ in Direct to Implant Breast Reconstruction- A Prospective Randomized Trial
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DEVICE: SurgiMend® Acellular Dermal Matrix|DEVICE: Strattice™ Acellular Dermal Matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Safety and Pharmacokinetics of Emapalumab in Adult Patients With HLH
Status: TERMINATED
Conditions: Hemophagocytic Lymphohistiocytoses
Interventions: DRUG: Emapalumab-Lzsg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarker Rule in/Out in Patients With Acute Diseases for Validation of AKI (BRAVA) Acute Kidney Injury
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: DIAGNOSTIC_TEST: Urine-TIMP-IGFBP7 biomarker for AKI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Autologous Conditioned Plasma (ACP) for Patients With Plantar Fasciitis
Status: UNKNOWN
Conditions: Chronic Plantar Fasciitis
Interventions: PROCEDURE: ACP|DRUG: Corticosteroid (celestone) injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Reduction During Intrauterine Device (IUD) Insertion in Outpatient Gynecology
Status: RECRUITING
Conditions: IUD Insertion Pain
Interventions: DEVICE: Transcutaneous electrical nerve stimulation (TENS)|DEVICE: Placebo Transcutaneous electrical nerve stimulation (TENS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Bepotastine Besilate Ophthalmic Solution in Seasonal Allergic Conjunctivitis Patients
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: bepotastine besilate ophthalmic solution|DRUG: placebo comparator ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Socio-ecological Cardiovascular Disease Prevention Intervention for Ultra-Orthodox Jewish Hasidic Women
Status: ENROLLING_BY_INVITATION
Conditions: Cardiovascular Diseases|Health Behavior
Interventions: OTHER: Socio-ecologial, community-based intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Implementing Geriatric Assessment for Dose Optimization of Cyclin-dependent Kinase (CDK) 4/6-inhibitors in Older Breast Cancer Patients
Status: RECRUITING
Conditions: Metastatic Breast Cancer|Advanced Breast Cancer|Quality of Life|Toxicity|Older Patients
Interventions: DRUG: CDK 4/6 inhibitors|DRUG: Endocrine therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesia Nociception Index Guided Remifentanil Administration During Propofol Anesthesia for Laparoscopic Surgery
Status: TERMINATED
Conditions: General Anesthesia
Interventions: PROCEDURE: ANI guided remifentanil|PROCEDURE: ANI blind arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: An Efficacy and Safety Study of a Combination of JNJ-73763989, Nucleos(t)Ide Analogs (NA), and a Programmed Cell Death Protein Receptor-1 (PD-1) Inhibitor in Chronic Hepatitis B Participants
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: JNJ-73763989|DRUG: PD-1 inhibitor|DRUG: Tenofovir Disoproxil|DRUG: Tenofovir Alafenamide|DRUG: Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fracture Risk With Thiazolidinediones
Status: COMPLETED
Conditions: Fractures, Bone|Type II Diabetes
Interventions: DRUG: TZD only (RSG or PIO or troglitazone)|DRUG: TZD + spironolactone|DRUG: TZD + amiloride
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Does Co-registration of OCT and Angiography Reduce Geographic Miss of Stent Implantation?
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Coronary PCI with OCT with Co Registration|PROCEDURE: Coronary PCI with OCT without Co Registration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Immunogenicity Following Recombinant Hepatitis B (Bio Farma) Vaccine in Adults & Children
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Recombinant Hepatitis B (Bio Farma) Vaccine|BIOLOGICAL: Recombinant Hepatitis B (Bio Farma) Vaccine®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Core Stabilization Exercises on Balance, Trunk Muscle Endurance and Posture on Sedentary Individuals
Status: ACTIVE_NOT_RECRUITING
Conditions: Core Stabilization|Sedentary Behavior
Interventions: OTHER: Core Stabilization Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the Penumbra™ System in Acute Middle Cerebral Artery (MCA) Stroke
Status: WITHDRAWN
Conditions: Stroke
Interventions: DEVICE: Penumbra™ System|DRUG: Recombinant tissue plasminogen activator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epileptiform EEG Patterns During Induction of General Anaesthesia With Sevoflurane Compared to Those With Propofol
Status: COMPLETED
Conditions: General Anaesthesia|Depth of Anaesthesia|Intraoperative Awareness|Seizures|Electroencephalography
Interventions: DEVICE: electroencephalography (EEG)|DEVICE: bispectral index (BIS)|DEVICE: response and state entropy (RE and SE)|DEVICE: middle latency auditory evoked potentials (MLAEP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Use of a Single Dose of Oral Prednisone in the Treatment of Cellulitis
Status: COMPLETED
Conditions: Cellulitis
Interventions: DRUG: Prednisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 2b Study of Zagociguat in Patients With MELAS
Status: NOT_YET_RECRUITING
Conditions: Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)
Interventions: DRUG: zagociguat 15mg|DRUG: zagociguat 30mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Dienogest and Dienogest Plus Estradiol Valerate in Ovarian Endometrioma
Status: UNKNOWN
Conditions: Ovarian Reserve
Interventions: DRUG: Estradiol valerate/dienogest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thoracoscopic Sentinel Lymph Node Biopsy in Patients With Stage I or Stage II Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Isosulfan blue|PROCEDURE: Axillary Lymph Node Dissection|PROCEDURE: Surgery|PROCEDURE: Sentinel Lymph Node Biopsy|PROCEDURE: Thoracoscopic Surgery|RADIATION: Technetium Tc 99m Sulfur Colloid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Integrated Intervention of Computerized Cognitive Training and Physical Exercise in Virtual Reality for People With Alzheimer's Disease (JDome)
Status: WITHDRAWN
Conditions: Alzheimer Disease
Interventions: DEVICE: Computerized cognitive training plus aerobic exercise with the JDome System|DEVICE: Computerized cognitive training plus aerobic exercise with standard exercise bike
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of 18-Months of Antidepressive Medication Plus CBT or Dynamic or Supportive Psychotherapy for Recurrent Major Depression
Status: UNKNOWN
Conditions: Major Depression
Interventions: DRUG: antidepressant medications, flexible drug choice|BEHAVIORAL: CBT, Psychodynamic or Supportive Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Clinical Experience on the Quality of Obturation and Periapical Changes of Teeth Treated With Matched Cones in Combination With Bioceramic Sealer
Status: RECRUITING
Conditions: Obturation
Interventions: PROCEDURE: Experienced dentist using lateral compaction with bioceramic sealer.|PROCEDURE: Unexperienced dentist using lateral compaction with bioceramic sealer.|PROCEDURE: Experienced dentist using Single cone with bioceramic sealer.|PROCEDURE: Unexperienced dentist using Single cone with bioceramic sealer.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Prospective Clinical Study of Endoscopic Foam Sclerotherapy for Internal Hemorrhoids
Status: UNKNOWN
Conditions: Grade/Stage I Hemorrhoids|Prolapsed Grade II Internal Haemorrhoid|Prolapsed Grade III Internal Haemorrhoid
Interventions: DRUG: Sclerosing foam of Lauromacrogol|DRUG: Sclersing liqiud of Lauromacrogol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Clinical Pharmacology and Safety of C1-esterase Inhibitor Administered by the Subcutaneous Route
Status: COMPLETED
Conditions: Hereditary Angioedema Types I and II
Interventions: BIOLOGICAL: C1-esterase inhibitor - single intravenous dose|BIOLOGICAL: C1-esterase inhibitor - subcutaneous low dose|BIOLOGICAL: C1-esterase inhibitor - subcutaneous medium dose|BIOLOGICAL: C1-esterase inhibitor - subcutaneous high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Exploring the Nature, Assessment and Treatment of Stuttering
Status: RECRUITING
Conditions: Stuttering|Stuttering, Adult|Stuttering, Childhood|Stuttering, Developmental
Interventions: BEHAVIORAL: The Blank Center CARE Model(TM) for Individuals who Stutter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stress, Emotion Regulation, and Alcohol in Women Veterans
Status: RECRUITING
Conditions: Alcohol Use Disorder|Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: Cognitive Reappraisal|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy Evaluation of the Robotic Enhanced Error Training of Upper Limb Function in Post-stroke and Post TBI Participants
Status: RECRUITING
Conditions: Stroke|Brain Injuries|Paresis|Cerebrovascular Disorders|Brain Diseases|Central Nervous System Diseases
Interventions: DEVICE: PlaXtreme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Double-Blind, Multiple Ascending Dose Study to Assess Safety, Tolerability and Pharmacokinetics of DX-2930 in Hereditary Angioedema Participants
Status: COMPLETED
Conditions: Hereditary Angioedema (HAE)
Interventions: DRUG: DX-2930|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bortezomib and Rituximab in Treating Patients With Post-Transplant Lymphoproliferative Disorders
Status: TERMINATED
Conditions: Lymphoproliferative Disorder
Interventions: BIOLOGICAL: rituximab|DRUG: bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About the Safety, Effects and Pharmacokinetics of Study Medication (PF-07054894) for the Treatment of Ulcerative Colitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: PF-07054894|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lateral Pedicled Nasoseptal Flaps for Endoscopic Draf III Procedure in Patients With Frontal Sinus Inverted Papilloma
Status: UNKNOWN
Conditions: Draf III Procedure|Naso-septal Flap|Inverted Papilloma
Interventions: PROCEDURE: Draf III procedure with lateral pedicled nasoseptal flaps applied|PROCEDURE: Draf III procedure without any flap applied
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Pharmacokinetics, Safety and Tolerability of Repeat Oral Doses of Darapladib (SB-480848) in Subjects With Severe Renal Impairment
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DRUG: Darapladib 160 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact Factors to Success Without Posterior Wall Puncture Using Dynamic Approach
Status: COMPLETED
Conditions: Radial Artery Catheterization|Ultrasound or Ultrasonography|Ultrasound-guided Short-axis Out-of-plane Dynamic Approach
Interventions: PROCEDURE: improvement of arterial depth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CHInese Medicine NeuroAid Efficacy on Stroke Recovery
Status: COMPLETED
Conditions: Cerebral Infarction|Stroke
Interventions: DRUG: NeuroAid|DRUG: NeuroAid matched Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Medications for Stopping Cocaine Dependence and Preventing Relapse
Status: COMPLETED
Conditions: Cocaine Abuse|Cocaine-Related Disorders
Interventions: DRUG: Modafinil|DRUG: Levodopa/Carbidopa|DRUG: Naltrexone HCl|DRUG: Placebo|BEHAVIORAL: Motivational Interviewing (MI)|BEHAVIORAL: Contingency management (CM)|BEHAVIORAL: Cognitive-Behavioral Therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prasugrel Versus Placebo in Adult Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Anemia
Interventions: DRUG: Prasugrel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Standard Tubal Ligation Versus Salpingectomy for Sterilization at the Time of Cesarean Delivery
Status: COMPLETED
Conditions: Method of Tubal Ligation at the Time of Cesarean Section
Interventions: PROCEDURE: Salpingectomy|PROCEDURE: Tubal ligation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Myofascial Release With and Without EMMETT Technique in Iliotibial Band Syndrome
Status: COMPLETED
Conditions: Iliotibial Band Syndrome
Interventions: OTHER: Manual myofascial release|OTHER: Emmett intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Metformin and Pioglitazone in Regulating Menstrual Irregularities and Hyperandrogenism
Status: UNKNOWN
Conditions: Menstrual Irregularities|Hyperandrogenism
Interventions: DRUG: TAB METFORMIN|DRUG: TAB PIOGLITAZONE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transfemoral Replacement of Aortic Valve With HLT MeriDIAN Valve Early Feasibility Trial
Status: TERMINATED
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: HLT Transcatheter Aortic Valve System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT