pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Assessment of the Glycemic Responses to Nutritional Products
Status: COMPLETED
Conditions: Glycemic Response
Interventions: DIETARY_SUPPLEMENT: First Reference product (dextrose, containing 25 g of carbohydrates)|DIETARY_SUPPLEMENT: Second Reference product (dextrose, containing 25 g of carbohydrates)|DIETARY_SUPPLEMENT: Third Reference product (dextrose, containing 25 g of carbohydrates)|DIETARY_SUPPLEMENT: High protein tube feed|DIETARY_SUPPLEMENT: High-protein tube feed with additional amino acid|DIETARY_SUPPLEMENT: Oral Nutritional Supplement for diabetes patients|DIETARY_SUPPLEMENT: Oral Nutritional Supplement for diabetes patients (new formula)|DIETARY_SUPPLEMENT: ONS for disease related malnutrition|DIETARY_SUPPLEMENT: Plantbased ONS for disease related malnutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Pharmacokinetic Interaction Between CKD-501 and Sulfonylurea
Status: COMPLETED
Conditions: Healthy Male Volunteer
Interventions: DRUG: CKD-501 0.5 mg tablet, Glimepiride 4 mg tablet|DRUG: CKD-501 placebo tablet, Glimepiride 4 mg tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: BNC105P in Combination With Everolimus/Following Everolimus For Progressive Metastatic Clear Cell Renal Cell Carcinoma
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Everolimus|DRUG: BNC105P
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BMS-986449 With and Without Nivolumab in Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: BMS-986449|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycemic Control and Treatment Satisfaction Using Finesse Versus Pen for Initiating Bolus Insulin Dosing in Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: Bolus Insulin Patch (Calibra Finesse)|DEVICE: Insulin Pen (Novo-Nordisk FlexPen®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Intervention for Diabetes and Weight Management in Psychosis
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder|Bipolar I Disorder|Substance-induced Psychosis|Psychotic Disorders|Major Depressive Disorder
Interventions: BEHAVIORAL: Lifestyle Intervention|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prebiotics as a Means to Modulate Gut Fermentation, Metabolism, Appetite and Cognition
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: OTHER: test meal|OTHER: reference meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Clinical Trial to Evaluate the Safety and Efficacy of 20 ml Cerebrolysin in Patients With Vascular Dementia
Status: COMPLETED
Conditions: Vascular Dementia
Interventions: DRUG: Cerebrolysin|DRUG: 0.9% Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Testing Buzzy Bee vs Vapocoolant During IV Placement
Status: COMPLETED
Conditions: Intravenous Administration
Interventions: DEVICE: Buzzy Bee|DRUG: Vapocoolent|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy Study for Geko Device in VLU Patients
Status: COMPLETED
Conditions: Venous Leg Ulcer|Leg Ulcers Venous|Leg Ulcer|Wound Leg|Wound
Interventions: DEVICE: geko™ medical device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of OPC-8212 (Vesnarinone) in Persons With AIDS-Related Kaposi's Sarcoma
Status: COMPLETED
Conditions: Sarcoma, Kaposi|HIV Infections
Interventions: DRUG: Vesnarinone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proton Beam Radiation Therapy and Chemotherapy in Treating Patients With Stage III Non-Small Cell Lung Cancer That Can Be Removed By Surgery
Status: COMPLETED
Conditions: Stage IIIA Non-small Cell Lung Cancer
Interventions: RADIATION: proton beam radiation therapy|DRUG: cisplatin|DRUG: etoposide|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate ONCOS-102 in Combination With Durvalumab in Subjects With Advanced Peritoneal Malignancies
Status: COMPLETED
Conditions: Colorectal Cancer|Ovarian Cancer|Appendiceal Cancer
Interventions: BIOLOGICAL: ONCOS-102|DRUG: Durvalumab|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Become of Patients From the Permanent Access to Care (PASS) in Cayenne, French Guyana, Suffering From a Chronic Disease (High Blood Pressure - Diabetes) in the Common Law Schemes
Status: COMPLETED
Conditions: Access to Health Services|Health Disparity, Minority and Vulnerable Populations|Chronic Disease|Social Security
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Analgesic Effects of Intravenous Paracetamol on Labor Pain
Status: COMPLETED
Conditions: Labor Pain
Interventions: DRUG: Acetaminophen|DRUG: Meperidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Insulin Glargine Versus. Neutral Protamine Hagedorn (NPH) Insulin in Children With Type 1 Diabetes Above 6 Years Old.
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Insulin glargine (HOE901)|DRUG: NPH insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Ibrutinib in Patients With Relapsed or Refractory Marginal Zone Lymphoma
Status: TERMINATED
Conditions: Lymphoma, B-Cell, Marginal Zone
Interventions: DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Specific Aquaporin-1 Inhibitor on Vascular Oxidative Stress in Healthy Volunteers
Status: COMPLETED
Conditions: Oxidative Stress|Cardiovascular Diseases|Bacopaside II|Bacopa Monnieri|Endothelial Dysfunction|Aquaporin 1|AQP1
Interventions: OTHER: KeenMind|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Long-term Treatment Effect of Intravitreal Ant-VEGF in Branch Retinal Vein Occlusion
Status: COMPLETED
Conditions: Branch Retinal Vein Occlusion
Interventions: DRUG: Lucentis intravitreal injection|DRUG: Avastin intravitreal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation to Enhance Cognition in Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: DEVICE: Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Contraceptive Efficacy & Safety of Phexxi™ (Previously Known as Amphora) Gel Compared to Conceptrol Vaginal Gel
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Conceptrol|DRUG: Amphora
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of High-dose IL-2 and High-dose IL-2 With Radiation Therapy in Patients With Metastatic Melanoma.
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Melanoma
Interventions: OTHER: Radiation therapy and high-dose IL-2|DRUG: High-dose IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Complete Revascularization Versus Culprit Lesion Only PCI in NSTEMI
Status: RECRUITING
Conditions: Non-ST-elevation Myocardial Infarction|Multivessel Coronary Artery Disease
Interventions: PROCEDURE: Culprit-lesion revascularization|PROCEDURE: Non-culprit-lesion revascularization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gene Expression Correlates of Post-Traumatic Stress Disorder (PTSD) Symptom Change After EFT (Emotional Freedom Techniques)
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic
Interventions: BEHAVIORAL: EFT (Emotional Freedom Techniques)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Biomechanical Determinants and Patterns Associated to the Pathophysiological Cascade of Ankle Arthropathy in Children With Haemophilia: Non-invasive In-vivo Measurement of Foot Joints in Children With Haemophilia During Gait.
Status: COMPLETED
Conditions: Haemophilia|Arthropathy
Interventions: OTHER: Gait analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Investigate the Absorption, Metabolism, and Excretion of Canagliflozin (JNJ-28431754) in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Radiolabelled 14C-canagliflozin (14C-JNJ-28431754)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effects of Single Ascending Oral Doses of ACD856 on Safety, Tolerability and Pharmacokinetics
Status: COMPLETED
Conditions: Alzheimer Disease|Cognition Disorder
Interventions: DRUG: ACD856|DRUG: Placebo|DRUG: ACD856 (fed cohort)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Scorpio Posterior Stabilised (PS) vs Scorpio NRG ("Energize") PS - Total Knee Arthroplasty
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee
Interventions: DEVICE: Scorpio PS (posterior stable)|DEVICE: Scorpio NRG PS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Botanical Oils Study to Determine Genetic Differences in the Way Your Body Processes Fats in Edible Oils
Status: COMPLETED
Conditions: Genetic Differences of Lipid Metabolism/Healthy Subjects
Interventions: DIETARY_SUPPLEMENT: soybean oil and borage oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Needle-Free Jet Injection of Lidocaine During Lumbar Puncture
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Buffered Lidocaine J-tip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of Muscle Energy Technique and Trigger Point Release in Plantar Fasciitis
Status: COMPLETED
Conditions: Plantar Fasciitis
Interventions: PROCEDURE: Muscle Energy Technique|PROCEDURE: Trigger Point Release|PROCEDURE: Self-Stretching of Calf and Plantar Fascia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Margetuximab Plus Tucatinib and Capecitabine in HER2-positive Metastatic Breast Cancer
Status: WITHDRAWN
Conditions: Metastatic Breast Cancer|Advanced Breast Cancer|HER2-positive Breast Cancer
Interventions: DRUG: Margetuximab|DRUG: Tucatinib|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IL-2 Expressing, Attenuated Salmonella Typhimurium in Unresectable Hepatic Spread
Status: COMPLETED
Conditions: Cancer of the Liver|Liver Cancer|Hepatoma|Liver Neoplasms|Biliary Cancer
Interventions: BIOLOGICAL: Salmonella typhimurium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Outcomes in the Early Use of Vasopressin in the Treatment of Septic Shock
Status: RECRUITING
Conditions: Septic Shock|Renal Function Replacement
Interventions: DRUG: vasopressin infusion when the norepinephrine dosage is equal to or greater than 0.25 mcg/kg/min|DRUG: vasopressin infusion when the norepinephrine dosage is equal to or greater than 0.5 mcg/kg/min
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Interest of Hydrophysiotherapy Care in Parkinson Disease's Motor and Non-motor Symptoms
Status: UNKNOWN
Conditions: Interest of Hydrophysiotherapy Care in Parkinson Disease's Non-motor Symptoms
Interventions: OTHER: Aquatic rehabilitation|OTHER: Land based physical activities|OTHER: Conventional rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treating Polysubstance Use Using a Novel Digital Technology
Status: RECRUITING
Conditions: Opioid Use|Opioid Use Disorder|Cocaine Use|Cocaine Use Disorder
Interventions: BEHAVIORAL: DynamiCare Health|DRUG: Methadone Treatment-As-Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Alpha-1 Antitrypsin (AAT) on the Progression of Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Type 1 Diabetes
Interventions: DRUG: Alpha 1-Antitrypsin (AAT, Aralast NP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3499446 in Participants With Advanced Solid Tumors With KRAS G12C Mutation
Status: TERMINATED
Conditions: Advanced Solid Tumor|Non-Small Cell Lung Cancer|Colorectal Cancer
Interventions: DRUG: LY3499446|DRUG: Abemaciclib|DRUG: Cetuximab|DRUG: Erlotinib|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dendritic Cell Immunotherapy for the Patients With Pancreatic Cancer
Status: COMPLETED
Conditions: Dendritic Cells|Pancreatic Neoplasms
Interventions: BIOLOGICAL: Dendritic cells pulsed with tumor lysate|BIOLOGICAL: Dendritic cells pulsed with MUC-1/WT-1 peptides
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Comparison of the Effectiveness of Two Types of Orthodontic Aligning Archwire Materials
Status: COMPLETED
Conditions: Teeth; Anomaly, Position
Interventions: PROCEDURE: Orthodontic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ezetimibe In Addition To Atorvastatin Therapy On The Plaque Composition In Patients With Acute Myocardial Infarction.
Status: COMPLETED
Conditions: ST-Segment Elevation Myocardial Infarction
Interventions: DRUG: Ezetimibe|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: [18F]-F13640 as a New Brain Radiopharmaceutical
Status: COMPLETED
Conditions: Neurological Pathology|Healthy Subjects
Interventions: DRUG: [18F]F13640|DRUG: [18F]F13640
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical, Radiographical, Histological Evaluation and Blood Flow Analysis of Alveolar Ridge Preservation
Status: RECRUITING
Conditions: Alveolar Bone Loss
Interventions: PROCEDURE: Extraction site development technique|DEVICE: autogenous tooth bone graft|PROCEDURE: Socket seal technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging Coronary Microvascular Dysfunction (CMD) Study
Status: ENROLLING_BY_INVITATION
Conditions: Angina|Non-obstructive Coronary Artery Disease
Interventions: RADIATION: PET imaging|RADIATION: Coronary CT angiogram|PROCEDURE: Functional Angiography|PROCEDURE: Treadmill exercise stress study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Pharmacokinetics (Movement of Drugs Within the Body), Safety and Tolerability of Brazikumab in Healthy Chinese and White Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Brazikumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Clinical Trial Assessing BT-001 Alone and in Combination With Pembrolizumab in Metastatic or Advanced Solid Tumors
Status: RECRUITING
Conditions: Metastatic Cancer|Soft Tissue Sarcoma|Merkel Cell Carcinoma|Melanoma|Triple Negative Breast Cancer|Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: BT-001|DRUG: Pembrolizumab [KEYTRUDA®]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study of Fertility-sparing Treatment Strategy in Patients With Early Cervical Cancer(SYSUGO-005/CSEM009)
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: Taxane|PROCEDURE: radical trachelectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pertussis Challenge Study in Adults Vaccinated With BPZE1
Status: COMPLETED
Conditions: Pertussis/Whooping Cough|Bordetella Pertussis, Whooping Cough
Interventions: BIOLOGICAL: BPZE1|BIOLOGICAL: Placebo|DRUG: Azithromycin|OTHER: Bordetella Pertussis Challenge Strain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase IIb Trial to Evaluate Longeveron Mesenchymal Stem Cells to Treat Aging Frailty
Status: COMPLETED
Conditions: Aging Frailty
Interventions: BIOLOGICAL: Longeveron Mesenchymal Stem Cells (LMSCs)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Seronegative Oligoarthritis of the Knee Study (SOKS)
Status: TERMINATED
Conditions: Spondylarthropathies
Interventions: DRUG: methylprednisolone|DRUG: Infliximab|DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetics Study for Pediatric Participants With Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Tadalafil- Tablet or Oral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EGG Test as a Predictor for an Individual Response to Treatment by Various Bariatric Procedures
Status: RECRUITING
Conditions: Bariatric Surgery|Gastric Motor Dysfunction|Gastroparesis
Interventions: DEVICE: ELECTROGASTROGRAPHY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Peony-Glycyrrhiza Decoction (PGD) for Antipsychotic-induced Hyperprolactinemia in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizophrenic Disorder|Hyperprolactinemia|Hyperprolactinaemia
Interventions: DRUG: PGD granules|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Recovery of Oxytocin Responsiveness in Pregnant Human Myometrial Explants After Oxytocin-Induced Desensitization
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sildenafil Therapy for Pulmonary Hypertension and Sickle Cell Disease
Status: TERMINATED
Conditions: Sickle Cell Disease|Pulmonary Hypertension
Interventions: DRUG: Sildenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Blood Flow Restriction Training on the Patients of Distal Radius Fracture
Status: COMPLETED
Conditions: Distal Radius Fracture
Interventions: OTHER: Traditional rehabilitation training|OTHER: Blood flow restriction combined with traditional rehabilitation training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Current Volume Under High-rate Nasal Oxygen Therapy During Acute Hypoxemic Respiratory Failure de Novo
Status: UNKNOWN
Conditions: Acute Hypoxemic Respiratory Failure
Interventions: DIAGNOSTIC_TEST: Assessment of tidal volume using Electrical Impedance Tomography (EIT) during high flow nasal canula(HFNC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Pharmaceutical Care on Primary Care Patients With Uncontrolled Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: Patient follow-up|BEHAVIORAL: Counseling|BEHAVIORAL: Drug dispensing|BEHAVIORAL: pharmacy usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Possible Role of Chloroquine to Induce a Complete Remission in the Treatment of Autoimmune Hepatitis: a Randomized Trial
Status: COMPLETED
Conditions: Autoimmune Hepatitis
Interventions: DRUG: Chloroquine diphosphate|DRUG: prednisone|DRUG: azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Lornoxicam or Ketorolac or Placebo for Post-Operative Pain After Bunionectomy
Status: COMPLETED
Conditions: Bunionectomy|Orthopedic Surgery
Interventions: DRUG: Lornoxicam 8 mg|DRUG: Lornoxicam 16 mg|DRUG: Ketorolac 30 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Immunogenicity of Chikungunya Vaccine
Status: COMPLETED
Conditions: Chikungunya
Interventions: BIOLOGICAL: Inactivated Chikungunya virus vaccine 20 mcg|BIOLOGICAL: Inactivated Chikungunya virus vaccine 30 mcg|BIOLOGICAL: Inactivated Chikungunya virus vaccine 10 mcg|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Biocellulose Sheet Containing Anti-hyperpigmentation Agent ("Biocellulose Mask", "Farhorm®") in Patients Receiving Laser Treatment
Status: COMPLETED
Conditions: Skin Pigmentation|Skin Irritation
Interventions: DEVICE: "Biocellulose Mask", Farhorm®"
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Curative Effect and Mechanism of Acupuncture on Neuropathic Pain in Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Sodium hyaluronate eye drops|OTHER: acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gait and REM Sleep Behavior Disorder
Status: TERMINATED
Conditions: Parkinson's Disease|REM Sleep Behavior Disorder
Interventions: RADIATION: FP-CIT single-photon emission computed tomography|BEHAVIORAL: neuropsychological evaluation|OTHER: Gait recording with sensors
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of EB01 Cream for the Treatment of Chronic Allergic Contact Dermatitis
Status: UNKNOWN
Conditions: Allergic Contact Dermatitis
Interventions: DRUG: EB01 Cream Placebo|DRUG: EB01 Cream 0.2%|DRUG: EB01 Cream 1.0%|DRUG: EB01 Cream 2.0%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modified White Blood Cells That Secrete IL-2 and Express a Protein That Targets the ESO-1tumor Protein for Metastatic Cancer
Status: TERMINATED
Conditions: Metastatic Cancer|Metastatic Melanoma|Metastatic Renal Cancer
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|OTHER: IL-12 &amp; Anti-NY ESO1 TCR PBL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy Dose Escalation in Locally Advanced Squamous Cell Carcinoma of the Larynx or Hypopharynx
Status: WITHDRAWN
Conditions: Advanced Squamous Cell Carcinoma
Interventions: RADIATION: Radiation Therapy|COMBINATION_PRODUCT: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measurement and Evaluation of Total Lung Capacity (TLC) in the Field of Pulmonary Functional Testing (PFT)
Status: COMPLETED
Conditions: TLC in Patients With and Without Respiratory System Disease
Interventions: DEVICE: Total Lung Capacity (TLC) testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of CD19/CD22 Dual Targeted CAR-T Cell Therapy in R/R B-Cell Acute Lymphoblastic Leukemia
Status: UNKNOWN
Conditions: CD19+ and CD 22+ B-ALL
Interventions: BIOLOGICAL: Autologous CD19/CD22 Chimeric Antigen Receptor T-cells|DRUG: Cyclophosphamide,Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-Portal vs Text-based Hypertension Monitoring Among Black Medicaid/Medicare Patients
Status: COMPLETED
Conditions: Hypertension|Cardiovascular Diseases
Interventions: BEHAVIORAL: Texting|BEHAVIORAL: Online patient portal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Influence of Anesthesia on Mechanical Efficiency of Left Ventricle in Patients Undergoing Open Heart Surgery
Status: TERMINATED
Conditions: Heart; Dysfunction Postoperative, Cardiac Surgery|Disorder; Heart, Functional, Postoperative, Cardiac Surgery
Interventions: DRUG: Isoflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Remind to Move" Treatment Versus Constraint-induced Movement Therapy for Children With Hemiplegic Cerebral Palsy
Status: COMPLETED
Conditions: Hemiplegic Cerebral Palsy|Upper Extremity Hemiplegia
Interventions: BEHAVIORAL: Remind-to-move|BEHAVIORAL: Modified constraint induced movement therapy|BEHAVIORAL: Conventional rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Stress Ball in Reducing Anxiety and Fear in 6-12 Year Old Children
Status: NOT_YET_RECRUITING
Conditions: Plaster of Paris Injury to Skin
Interventions: OTHER: Squeeze the stress ball.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of AER 001 Administered by Nebulization on Antigen Challenge in Atopic Asthmatics
Status: COMPLETED
Conditions: Allergic Asthma
Interventions: DRUG: AER 001|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan, Carboplatin, Bevacizumab in the Treatment of Patients With Extensive Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Small Cell Lung
Interventions: DRUG: irinotecan|DRUG: carboplatin|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study Using Hybrid PET/MRI to Evaluate Men With Suspected Recurrence Following Treatment for Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: OTHER: 18F-FCH PET/MRI imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Prospective Trial in Patients With Crohn's Disease in Remission and Having Irritable Bowel Syndrome-like Symptoms
Status: NOT_YET_RECRUITING
Conditions: Irritable Bowel Syndrome-like Symptoms|Crohn Disease Remission
Interventions: OTHER: BK003|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Pinloc Versus Hansson Pins in the Treatment of Femoral Neck Fractures.
Status: UNKNOWN
Conditions: Femoral Neck Fractures
Interventions: DEVICE: Pinloc|DEVICE: Hansson Pins (LIH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-blind Pilot Trial of Mirtazapine for the Treatment of Co-occurring AD/MDD.
Status: COMPLETED
Conditions: Major Depressive Disorder|Alcohol Use Disorder
Interventions: DRUG: Mirtazapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Histone-deacetylase Inhibitor ITF2357 in Refractory/Relapsed Lymphocytic Leukemia
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: ITF2357
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Healthy Female and Male Volunteers Aspirin Study
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Capsule ASA 81mg/esomeprazole 20mg|DRUG: Acetylsalicylzuur Apotex Cardio
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: EFFECTS of BEETROOT JUICE INGESTION in POSTMENOPAUSAL HYPERTENSIVE WOMEN.
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension|Menopause
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Temsirolimus, Topotecan, and Bortezomib
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DRUG: Torisel (Temsirolimus)|DRUG: Hycamtin (Topotecan)|DRUG: Velcade (Bortezomib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of VR VS Conservative Treatment in Sensorimotor Function of Upper Extremity in Chronic Stroke Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Stroke
Interventions: BEHAVIORAL: Virtual Reality (VR) Therapy|OTHER: Conservative Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase I Study of G3139 Subcutaneous in Solid Tumors
Status: COMPLETED
Conditions: Tumors
Interventions: DRUG: G3139, Oblimersen sodium, Bcl-2 antisense oligonucleotide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Cotadutide Given by Subcutaneous Injection in Adult Participants With Non-cirrhotic Non-alcoholic Steatohepatitis With Fibrosis
Status: COMPLETED
Conditions: Non-cirrhotic Non-alcoholic Steatohepatitis With Fibrosis
Interventions: DRUG: Cotadutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Biomarkers Levels in Gingival Crevicular Fluid, Saliva and Serum for Different Periodontal Diseases
Status: COMPLETED
Conditions: Mouth Diseases|Periodontal Inflammation|Periodontal Diseases
Interventions: DIAGNOSTIC_TEST: GCF obtaining|DIAGNOSTIC_TEST: Saliva Obtaining|DIAGNOSTIC_TEST: Serum obtaining
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Real-world Treatment of H. Pylori Eradication in Patients With Comorbidity
Status: COMPLETED
Conditions: Helicobacter Pylori Infection|Comorbidities and Coexisting Conditions|Real-world Outcome|Medication Adherence|Patient Compliance|Patient Dropouts
Interventions: DRUG: The sequential therapy|DRUG: The triple therapy|DRUG: The hybrid therapy|DRUG: The concomitant therapy|DRUG: Bismuth-based quadruple therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigation of the Role of 905-nm Laser Light in the Delay of Muscle Fatigue
Status: COMPLETED
Conditions: Muscle Fatigue
Interventions: DEVICE: Control|DEVICE: 800 nm laser|DEVICE: combination laser|DEVICE: 905 nm laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas
Status: RECRUITING
Conditions: Anaplastic Astrocytoma, IDH-Wildtype|Anaplastic Oligoastrocytoma|Anaplastic Oligodendroglioma|Diffuse Astrocytoma, IDH-Wildtype|Glioblastoma|Oligoastrocytoma|Oligodendroglioma|WHO Grade II Glioma|WHO Grade III Glioma
Interventions: OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Radiation Therapy|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Vaccination With Poly-ICLC and Peptide-pulsed Dendritic Cells
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: Poly ICLC|PROCEDURE: leukapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-escalation Study of Combination BMS-936558 (MDX-1106) and Ipilimumab in Subjects With Unresectable Stage III or Stage IV Malignant Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: DRUG: BMS-936558 (MDX1106-04)|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of Circulating and Tumor-infiltrating Immune Cells in Malignant Brain Tumors
Status: RECRUITING
Conditions: Brain Tumor, Primary|Brain Tumor - Metastatic
Interventions: DIAGNOSTIC_TEST: Circulating leukocytes immunophenotype|DIAGNOSTIC_TEST: Tumor sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Medico-economic Comparison Between Treatment With Panretinal Photocoagulation by Laser in 1 Session Versus 4 Sessions in Diabetic Retinopathy
Status: RECRUITING
Conditions: Diabetic Retinopathy
Interventions: PROCEDURE: monospot panretinal photocoagulation|PROCEDURE: multispot panretinal photocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Napabucasin Plus Nab-Paclitaxel With Gemcitabine in Adult Patients With Metastatic Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Carcinoma, Pancreatic Ductal
Interventions: DRUG: Napabucasin|DRUG: Nab-paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Electric 3D Versus Manual Toothbrushes in Patients With Fixed Orthodontic Appliances
Status: COMPLETED
Conditions: Gingivitis|Dental Plaque
Interventions: DEVICE: Electric3D|DEVICE: Manual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Therapy of Topical Imiquimod Plus Multipeptide Vaccination for Cutaneous Metastases of Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: MELITAC 12.1|DRUG: Imiquimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: taVNS Paired With Motor Training for Upper-extremity Rehabilitation in Stroke Patients
Status: RECRUITING
Conditions: Upper Extremity Dysfunction|Stroke
Interventions: DEVICE: paired taVNS|DEVICE: Unpaired taVNS|DEVICE: Sham taVNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Research With Diverse Families
Status: NOT_YET_RECRUITING
Conditions: Attention Deficit/Hyperactivity Disorder|Emotional Dysfunction|Irritable Mood
Interventions: DIETARY_SUPPLEMENT: Broad Spectrum Micronutrients; a 36-ingredient blend of vitamins, minerals, amino acids, and antioxidants
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Inactivated, Split-Virion Influenza Vaccine and Standard Fluzone® Vaccine in Adult and Elderly Subjects
Status: COMPLETED
Conditions: Influenza|Myxovirus Infection
Interventions: BIOLOGICAL: Split, Inactivated, Trivalent Influenza Vaccine (Intradermal Formulation 1)|BIOLOGICAL: Split, Inactivated, Trivalent Influenza Vaccine (Intradermal Formulation 2)|BIOLOGICAL: Split, Inactivated, Trivalent Influenza Vaccine (Standard dose)|BIOLOGICAL: Split, Inactivated, Trivalent Influenza Vaccine (High-dose)|BIOLOGICAL: Split, Inactivated, Trivalent Influenza Vaccine (Standard dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Degenerative Meniscus Without Osteoarthritis : Arthroscopic Partial Menisectomy Versus Platelet Rich Plasma (APM-PRP)
Status: UNKNOWN
Conditions: Meniscectomy|Platelet-Rich Plasma|Meniscus; Degeneration
Interventions: PROCEDURE: Arthroscopic Partial Meniscectomy|PROCEDURE: Platet- Rich-Plasma|OTHER: Post-intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug Drug Interaction of Empagliflozin (BI 10773) and Warfarin in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 10773 25 mg|DRUG: Warfarin 25 mg|DRUG: BI 10773 25 mg|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bendamustine and Rituximab Alternating With Cytarabine and Rituximab for Untreated Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Bendamustine|DRUG: Rituximab|DRUG: Cytarabine|DRUG: Pegfilgrastim|PROCEDURE: Leukapheresis|DRUG: Filgrastim|PROCEDURE: Autologous stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Low Level Laser Therapy on Particular Joint Points and Acupuncture Points on Knee Joints in Grade III Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Low level laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of a Training Intervention to Improve Mental Health Treatment for Gender Minority Youth
Status: ACTIVE_NOT_RECRUITING
Conditions: Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: Gender-Affirming Psychotherapy (GAP) Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Open-Label, Nonrandomized, Multicenter Extension Study to Evaluate the Long-term Safety and Efficacy of Pegcetacoplan in Participants With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis
Status: ACTIVE_NOT_RECRUITING
Conditions: C3G|IC-MPGN|C3 Glomerulopathy|C3 Glomerulonephritis|Complement 3 Glomerulopathy|Complement 3 Glomerulopathy (C3G)|Complement 3 Glomerulonephritis|Dense Deposit Disease|DDD|Membranoproliferative Glomerulonephritis|Membranoproliferative Glomerulonephritis (MPGN)|Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)
Interventions: DRUG: Pegcetacoplan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Partial Bladder Filling on Post-operative Time to Void in Minimally Invasive Gynecologic Procedures
Status: COMPLETED
Conditions: Hysterectomy|Myomectomy
Interventions: OTHER: Bladder filled with saline solution|OTHER: saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Bioequivalence of Xisimin (Loratadine) Tablets Under Fasting and Fed Conditions in Healthy Participants Compared With Clarityne Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Loratadine (Xisimin [Test Treatment])|DRUG: Loratadine (Clarityne [Reference Treatment])
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Efficacy and Safety of Rituximab and Mycophenolate Mofetil Combination in Patients With Interstitial Lung Disease Related to Systemic Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Interstitial Lung Disease With Systemic Sclerosis
Interventions: DRUG: Rituximab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Pharmacodynamic Study of Emixustat in Subjects With Geographic Atrophy Associated With Dry Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Geographic Atrophy|Age-Related Macular Degeneration
Interventions: DRUG: Emixustat HCl Tablet|OTHER: Placebo Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Family Integrated Care on Melatonin Level in Very Low Birth Weight Infants
Status: NOT_YET_RECRUITING
Conditions: Very Low Birth Weight Infant
Interventions: BEHAVIORAL: Family integrated care intervention group|BEHAVIORAL: Routine nursing care group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pharmacokinetic Study of AA4500 (XIAFLEX™, Proposed Name) in Subjects With Dupuytren's Contracture
Status: COMPLETED
Conditions: Dupuytren's Contracture
Interventions: BIOLOGICAL: collagenase clostridium histolyticum
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: MY-ENDO -- Mind Your ENDOmetriosis: a Digital Mindfulness- and Acceptance-based Endometriosis Self-management Program
Status: RECRUITING
Conditions: Endometriosis
Interventions: BEHAVIORAL: Digitally delivered mindfulness- and acceptance-based psychological intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Bolus Comparing With Continuous Drip of 3% NaCl in Patients With Severe Symptomatic Hyponatremia.
Status: UNKNOWN
Conditions: Hyponatremia|Osmotic Demyelination Syndrome
Interventions: OTHER: 3%NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iodine Impact on Thyroid Function and Psychomotor Development, Observational Study in the Portuguese Minho Region
Status: RECRUITING
Conditions: Iodine Deficiency|Thyroid|Pregnancy Related|Psychomotor Impairment|Hypothyroidism in Pregnancy|Nutrient Deficiency
Interventions: DIETARY_SUPPLEMENT: Iodine supplementation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p