pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Enteral Nutrition in Congestive Heart Failure and Cardiac Cachexia
Status: COMPLETED
Conditions: Chronic Heart Failure|Cardiac Cachexia
Interventions: DIETARY_SUPPLEMENT: NutriDrink|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decompressive Hemicraniectomy in Intracerebral Hemorrhage
Status: ACTIVE_NOT_RECRUITING
Conditions: Cerebral Hemorrhage
Interventions: PROCEDURE: Decompressive craniectomy (DC) and best medical treatment|PROCEDURE: Best medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study to Treat Subjects With Advanced Renal Cell Carcinoma
Status: COMPLETED
Conditions: Advanced Renal Cell Carcinoma
Interventions: DRUG: AMG 102 at 10 mg/kg|DRUG: AMG 102 at 20 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Knotless Suture in Revision Total Joint Arthroplasty
Status: COMPLETED
Conditions: Arthroplasty
Interventions: DEVICE: Conventional Closure: Knee|DEVICE: Barbed suture closure: Knee|DEVICE: Conventional Closure: Hip|DEVICE: Barbed suture closure: Hip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of the Efficacy, Safety and Tolerability of Oral CEP-701 in Patients With Severe Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: CEP-701 20mg|DRUG: CEP-701 40mg|DRUG: CEP-701 60mg|DRUG: CEP-701 80mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of AZD0466 Monotherapy or in Combination in Patients With Advanced Haematological Malignancies
Status: TERMINATED
Conditions: Haematological Malignancies
Interventions: DRUG: AZD0466|DRUG: Voriconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Oral Carbohydrate Loading in Gynecologic Surgery
Status: COMPLETED
Conditions: Postoperative Recovery
Interventions: DIETARY_SUPPLEMENT: NO-NPO (Daesang WelLife Co., Ltd., Korea)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Buprenorphine Plus Baclofen to Increase Analgesia in Healthy Volunteers
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Pain|Analgesia
Interventions: DRUG: Placebos|DRUG: Baclofen 5 mg|DRUG: Baclofen 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Technical Performance Assessment of Tc-99m Tetrofosmin for Differentiation of Recurrence vs Radiation Necrosis in Patients With Glioma
Status: COMPLETED
Conditions: Glioma (Diagnosis)
Interventions: DEVICE: Tc-99M-Tetrofosmin SPECT|DEVICE: F-18 FDG PET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Pes Planus on Quality of Life
Status: NOT_YET_RECRUITING
Conditions: Pes Planus
Interventions: OTHER: Survey Navicular Drop test, International Physical Activity Questionnaire (IPAQ) Short Form, 6-minute walk test, Foot Function Index (AFI), SF-36 quality of life questionnaire, Modified borg scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Personalized Dietary Advice on Health Status of Diabetes Type 2 Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Personalized Dietary Advice Services|BEHAVIORAL: Regular care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy for the Treatment of Chronic Rhinosinusitis
Status: UNKNOWN
Conditions: Chronic Sinusitis
Interventions: DEVICE: Photodisinfection (antimicrobial photodynamic therapy, aPDT)|DEVICE: Saline irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contrast-Enhanced Digital Mammography (CEDM) for Identifying a Change in Management of Women With Newly Diagnosed Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DEVICE: CE-BMRI|DEVICE: DE-CEDM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of an Investigational Drug for the Prevention of Thrombosis-related Events Following Hip Replacement Surgery (ADVANCE-3)
Status: COMPLETED
Conditions: Deep Vein Thrombosis|Pulmonary Embolism
Interventions: DRUG: Enoxaparin|DRUG: Apixaban|DRUG: Enoxaparin-matching placebo|DRUG: Apixaban-matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Oral Treatment With BIBF 1120 Together With Docetaxel and Prednisone in Patients With Hormone Refractory Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: BIBF 1120
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dried Plums Prevent Inflammation And Improve Bone Health in Osteopenic Men
Status: COMPLETED
Conditions: Osteoporosis, Osteopenia
Interventions: DIETARY_SUPPLEMENT: Dried Plum|DIETARY_SUPPLEMENT: 800 IU vitamin D and 450mg elemental calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Newly Diagnosed Ovarian Cancer With Antioxidants
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DIETARY_SUPPLEMENT: Oral Ascorbic Acid|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Sodium Ascorbate|DIETARY_SUPPLEMENT: Oral Mixed natural Carotenoids with Vitamin A|DIETARY_SUPPLEMENT: Vitamin E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Durvalumab (MEDI4736) Plus Total Neoadjuvant Therapy (TNT) in Locally Advanced Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: DRUG: Durvalumab (MEDI4736)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cervical Ripening Before Endometrial Biopsy in Abnormal Uterine Bleeding Using Sublingual Misoprostol
Status: UNKNOWN
Conditions: Abnormal Uterine Bleeding Unrelated to Menstrual Cycle
Interventions: DRUG: Misoprostol|DRUG: Vitamin B6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Study for the Outpatient Treatment of Patients With Very Low Risk Acute Symptomatic Pulmonary Embolism.
Status: RECRUITING
Conditions: Acute Pulmonary Embolism|Outpatient Treatment
Interventions: OTHER: Outpatient treatment with standard anticoagulant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Real-world Research on the Prevention and Treatment of Peritoneal Metastasis and Malignant Ascites by Intraperitoneal Infusion of rmhTNF in Gastric and Colorectal Malignant Tumors
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Recombinant Mutant Human Tumor Necrosis Factor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Medical Clowns and Topical Anesthetic Cream on Pain and Anxiety in Children Undergoing Allergy Skin Tests
Status: COMPLETED
Conditions: Anxiety Disorder|Allergic Skin Reaction
Interventions: BIOLOGICAL: Cream of Macrogol cetostearyl ethers|DRUG: Cream of Lidocaine 2.5 %.and Prilocaine 2.5 %|BEHAVIORAL: Care and treatment from a medical clown|BEHAVIORAL: Care and treatment from a medical clown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Precursors of Binge Eating Disorder in a Clinical Sample of Adolescents With Obesity
Status: RECRUITING
Conditions: Binge-Eating Disorder|Obesity|Eating Disorders|BED|Other Specified Feeding or Eating Disorder|Eating Disorder Nos|Emotion Regulation|Food Addiction
Interventions: DIAGNOSTIC_TEST: Magnetic resonance imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: GA YAZ ACNE in China Phase III
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: EE20/Drospirenone (YAZ, BAY86-5300)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Role of Pictorial Asthma Action Plans to Promote Self-management in Rural Youth With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Pictorial Asthma Action Plan|BEHAVIORAL: Written Asthma Action Plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Aloe Vera in the Inflammation of Patients With Mild Ulcerative Colitis
Status: UNKNOWN
Conditions: Ulcerative Colitis
Interventions: DIETARY_SUPPLEMENT: Aloe Barbadensis Miller|DIETARY_SUPPLEMENT: placebo water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Vismodegib in Patients With Advanced Solid Malignancies Including Hepatocellular Carcinoma With Varying Degrees of Renal or Hepatic Function
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Vismodegib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain, Anxiety During Interventional Spine Procedures
Status: COMPLETED
Conditions: Pain|Low Back Pain|Procedural Pain|Procedural Anxiety
Interventions: OTHER: Lavender oil|OTHER: Almond oil|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety Study Of N-Acetylcysteine For Prevention Of Contrast Induced Nephropathy In Patients w/Stage 3 Renal Failure
Status: TERMINATED
Conditions: Contrast Induced Nephropathy
Interventions: DRUG: N-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effects of Treatment With Aprepitant (Emend®) in HIV Infected Individuals
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Placebo|DRUG: Aprepitant|DRUG: Aprepitant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DEC-205/NY-ESO-1 Fusion Protein CDX-1401, Poly ICLC, Decitabine, and Nivolumab in Treating Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Blasts 30 Percent or Less of Bone Marrow Nucleated Cells|Chronic Myelomonocytic Leukemia|High Risk Myelodysplastic Syndrome|Myelodysplastic Syndrome|Refractory Anemia
Interventions: BIOLOGICAL: DEC-205/NY-ESO-1 Fusion Protein CDX-1401|DRUG: Decitabine|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab|DRUG: Poly ICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treat & Extend Versus Fixed Dosing With Faricimab for Management of Diabetic Macular Edema: A Pragmatic, Multi-center, Open-label, Randomized, Controlled Trial
Status: RECRUITING
Conditions: Diabetic Macular Edema
Interventions: DRUG: Faricimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of a Probiotic Food Supplement Containing B. Infantis (EVC001) in Healthy Breastfed Infants at Risk of Developing Atopic Dermatitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: OTHER: B. infantis|OTHER: Lactose Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Safety and Efficacy of Sirolimus for Injection (Albumin-bound) in Patients With Advanced Malignant Perivascular Epithelioid Cell Tumor (PEComa)
Status: RECRUITING
Conditions: Advanced Malignant Perivascular Epithelioid Cell Tumor (PEComa)
Interventions: DRUG: Sirolimus for Injection (Albumin Bound)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of the Renin Angiotensin Aldosterone System in the Mechanisms of Transition to Heart Failure in Abdominal Obesity
Status: COMPLETED
Conditions: Obesity, Abdominal
Interventions: OTHER: Urine sample|OTHER: Blood sample|OTHER: Assessment of sleep apnea syndrome|OTHER: Electrocardiogram|OTHER: Glucose tolerance test|OTHER: Echocardiography|OTHER: cardiac and abdominal magnetic resonance imaging|OTHER: Ambulatory blood pressure monitoring|OTHER: Echotracking|OTHER: Pulse wave velocity|OTHER: Composition of body mass by Dual x-ray absorptiometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy of Delayed Enhancement MRI-Guided Ablation vs Conventional Catheter Ablation of Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation|Fibrosis
Interventions: PROCEDURE: MRI-Guided Ablation|PROCEDURE: Conventional Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of VIIT in Adults With NASH
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis (NASH)|Nonalcoholic Fatty Liver|Nonalcoholic Steatohepatitis|Liver Diseases
Interventions: BEHAVIORAL: Vigorous-intensity interval training (VIIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Do Pharyngeal Packs During Orthognathic Surgery Reduce Postoperative Nausea and Vomiting
Status: UNKNOWN
Conditions: Nausea|Vomiting
Interventions: DEVICE: pharyngeal pack
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Etripamil for the Termination of Spontaneous Paroxysmal Supraventricular Tachycardia (PSVT).
Status: TERMINATED
Conditions: Paroxysmal Supraventricular Tachycardia
Interventions: DRUG: Etripamil|DRUG: Placebo|DRUG: Etripamil Test Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BVA-200 vs BVA-100 Validation Study
Status: COMPLETED
Conditions: Heart Failure|High Blood Pressure|High Cholesterol|Anemia|Diabetes|Thyroid Diseases|Kidney Diseases|Clotting Disorder|Trauma|Other Disease
Interventions: DIAGNOSTIC_TEST: BVA-200
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MG4101 Plus Rituximab Including Lymphodepletion in Patient With r/r NHL B-cell Origin
Status: UNKNOWN
Conditions: Relapsed Non Hodgkin Lymphoma|Refractory Non-Hodgkin Lymphoma
Interventions: DRUG: Rituximab|DRUG: Fludarabine|DRUG: Cyclophosphamide|BIOLOGICAL: MG4101(allogeneic Natural Killer cell)|DRUG: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The MentalPlus® for Assessment and Rehabilitation of Cognitive Function After Remission of the Symptoms of COVID-19
Status: COMPLETED
Conditions: Cognitive Impairment|Covid19|Cognitive Dysfunction|Depression, Anxiety|Quality of Life
Interventions: DEVICE: The use of the MentalPlus® digital game for assessment and rehabilitation of cognitive function after remission of the symptoms of COVID-19
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Hypothermia Plus Magnesium Sulphate(MgSO4) in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy
Status: UNKNOWN
Conditions: Severe Hypoxic Ischemic Encephalopathy|Moderate Hypoxic Ischemic Encephalopathy
Interventions: DRUG: Magnesium Sulphate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess Analgesic Efficacy of Intravenous Lignocaine
Status: COMPLETED
Conditions: Postoperative Pain|Postoperative Nausea and Vomiting|Postoperative Ileus
Interventions: DRUG: Intravenous lignocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept Study of EMBalance Decision Support System to Evaluate Balance Disorders
Status: COMPLETED
Conditions: Dizziness|Vertigo
Interventions: OTHER: Decision Support System (DSS)|OTHER: Specialist Audiovestibular Consultation|OTHER: DSS Customised Vestibular Physiotherapy|OTHER: Standard Physiotherapy Practice|OTHER: Follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy Study of LIPO-202 for the Reduction of Central Abdominal Bulging in Obese Subjects
Status: COMPLETED
Conditions: Central Abdominal Bulging
Interventions: DRUG: LIPO-202|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Raloxifene Hydrochloride and Placebo in the Treatment of Postmenopausal Women With Osteoporosis
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal
Interventions: DRUG: Raloxifene HCL|DRUG: Raloxifene HCL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Assess the PK/PD of YYD601 20mg After Oral Administration if Healthy Adult Subjects (Phase1)
Status: COMPLETED
Conditions: GERD
Interventions: DRUG: YYD601 20mg|DRUG: Nexium tab 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peer Support for Patients With Diabetic Foot Ulcers
Status: RECRUITING
Conditions: Diabetic Foot Ulcer|Diabetic Wound|Diabetes Mellitus, Type 2|Diabetic Foot|Diabetes Complications|Peripheral Neuropathy
Interventions: BEHAVIORAL: Peer counseling group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pilot Study of Ruxolitinib in Relapsed or Refractory Hodgkin Lymphoma and Primary Mediastinal Large B-cell Lymphoma
Status: COMPLETED
Conditions: Relapsed or Refractory Hodgkin Lymphoma|Primary Mediastinal Large B-cell Lymphoma
Interventions: DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Analysis of Intravenous Rapid Infusion of Obinutuzumab in Patients With B-cell Non-Hodgkin's Lymphoma in China
Status: UNKNOWN
Conditions: Obinutuzumab|Rapid Infusion|Intravenous Infusion Reaction
Interventions: DRUG: intravenous rapid infusion of obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: POLish Bifurcation Optimal Treatment Strategy Study for Left Main Bifurcation Percutaneous Coronary Intervention (PCI)
Status: TERMINATED
Conditions: Coronary Stenosis
Interventions: DEVICE: BiOSS LIM C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Music Therapy to Restore Motor Deficits After Stroke
Status: UNKNOWN
Conditions: Stroke|Paresis
Interventions: BEHAVIORAL: Music-supported Therapy|BEHAVIORAL: home-based Music-supported Therapy|BEHAVIORAL: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of GBS Colonization Via Immunity
Status: COMPLETED
Conditions: Beta Haemolytic Streptococcal Infection
Interventions: BIOLOGICAL: GBS III-TT|BIOLOGICAL: Tetanus and diptheria toxoids vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Use of Stromal Vascular Fraction in Multiple Sclerosis
Status: SUSPENDED
Conditions: Multiple Sclerosis|Autoimmune
Interventions: PROCEDURE: Microcannula Harvest Adipose Stroma|DEVICE: Centricyte 1000|PROCEDURE: Sterile Normal Saline IV Deployment of cSVF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Concordance of Detecting EGFR (Epidermal Growth Factor Receptor) Mutation by Circulating Tumour Free DNA Versus Tissues Biopsy in NSCLC (Non-small Cell Lung Cancer).
Status: COMPLETED
Conditions: NSCLC (Non-small Cell Lung Cancer)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Pharmacokinetic Drug Interaction Between Rosuvastatin and Telmisartan/Amlodipine
Status: COMPLETED
Conditions: Hypertension|Hyperlipidemia
Interventions: DRUG: Rosuvastatin|DRUG: Telmisartan/Amlodipine|DRUG: Rosuvastatin and Telmisartan/Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous (IV) Pantoprazole for Gastroesophageal Reflux Disease (GERD) in Neonates and Infants
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: pantoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Value of Bronchoscopic and Thoracoscopic Frozen Section Biopsies in Patients With Pleuropulmonary Tumors
Status: UNKNOWN
Conditions: Event of Undetermined Intent (Y21-Y33)
Interventions: DIAGNOSTIC_TEST: Bronchoscopic and thoracoscopic frozen section biopsies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Oral Budesonide in the Treatment of Patients With Primary Biliary Cirrhosis and Overlap Features of Autoimmune Hepatitis
Status: WITHDRAWN
Conditions: Primary Biliary Cirrhosis|Autoimmune Hepatitis
Interventions: DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ribavirin/Pegasys Treatment of Recurrent Hepatitis C After Liver Transplant
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Ribavirin|DRUG: Pegylated interferon alpha2a
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance (MR) Guided, Dose-Escalated Radiation Therapy (RT) + Chemotherapy in Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Unresectable Pancreatic Cancer
Interventions: RADIATION: Radiation Therapy|DRUG: Concurrent chemotherapy (Gemcitabine, Capecitabine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LEE001 and Chemoembolization In Patients With Advanced Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: LEE011|PROCEDURE: Chemoembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy in Treating Post-Menopausal Women With Early Stage Breast Cancer Undergoing Surgery
Status: TERMINATED
Conditions: Ductal Breast Carcinoma In Situ|Estrogen Receptor Negative|Estrogen Receptor Positive|HER2/Neu Negative|Invasive Cribriform Breast Carcinoma|Invasive Ductal Carcinoma, Not Otherwise Specified|Lobular Breast Carcinoma In Situ|Mucinous Breast Carcinoma|Papillary Breast Carcinoma|Progesterone Receptor Positive|Stage I Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIC Breast Cancer|Tubular Breast Carcinoma
Interventions: PROCEDURE: Therapeutic Conventional Surgery|RADIATION: Radiation Therapy|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Assessing the Safety and Efficacy of Adding Ipatasertib to Paclitaxel Treatment in Participants With Breast Cancer That Has Spread Beyond the Initial Site, and the Cancer Does Not Have Certain Hormonal Receptors
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Ipatasertib|DRUG: Paclitaxel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Efficacy of the Mediterranean Diet to the Low- Fermentable, Oligosaccharides, Disaccharides, Monosaccharides, and Polyols (FODMAP) Diet in Treating Irritable Bowel Syndrome(IBS)
Status: RECRUITING
Conditions: Irritable Bowel Syndrome
Interventions: OTHER: Diet low in all FODMAP groups|OTHER: Diet - Mediterranean
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of GLS-010 Plus Platinum-containing Chemotherapy±Bevacizumab as First-line Treatment for Persistent, Recurrent, or Metastatic Cervical Cancer
Status: NOT_YET_RECRUITING
Conditions: Persistent, Recurrent, or Metastatic Cervical Cancer
Interventions: DRUG: GLS-010|DRUG: Placebo|DRUG: paclitaxel|DRUG: cisplatin|DRUG: carboplatin|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of SC-003 Alone and in Combination With ABBV-181 in Subjects With Platinum-Resistant/Refractory Ovarian Cancer
Status: TERMINATED
Conditions: Ovarian Cancer
Interventions: DRUG: SC-003|DRUG: SC-003 in combination with ABBV-181
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azathioprine or Mycophenolate Mofetil for Bullous Pemphigoid
Status: COMPLETED
Conditions: Bullous Pemphigoid
Interventions: DRUG: Azathioprine or Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development Of a Virtual Stress Inoculation Training (SIT) Platform and Mobile Health App
Status: RECRUITING
Conditions: PTSD|Trauma and Stressor Related Disorders|Traumatic Brain Injury
Interventions: BEHAVIORAL: Stress NAVIGATOR (Mobile Health Application)|BEHAVIORAL: SIT NAVIGATOR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ideal Time of Oxytocin Infusion During Cesarean Section
Status: TERMINATED
Conditions: Blood Loss, Surgical|Postpartum Hemorrhage|Bleed Pregnancy|Pregnancy Related|Cesarean Section Complications
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Outcome and Tunnel Widening After ACL Reconstruction: Comparison of Aperture and Cortical Fixation
Status: UNKNOWN
Conditions: ACL Anterior Cruciate Ligament Injury|Outcome
Interventions: DEVICE: Biocomposite interference screw|DEVICE: Extracortical ACL Tightrope fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combining HIIT and n-3 PUFA to Reduce Inflammation and Improve Metabolic Health
Status: UNKNOWN
Conditions: Obesity|Inflammation|Human Microbiome|Insulin Resistance|Dyslipidemias
Interventions: DIETARY_SUPPLEMENT: Omega-3 polyunsaturated fatty acid|BEHAVIORAL: High-Intensity Interval Training|DIETARY_SUPPLEMENT: Safflower oil|BEHAVIORAL: Flexibility training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate GSK1325760A - a Long-Term Extension Study
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension|Hypertension, Pulmonary
Interventions: DRUG: GSK1325760A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Bioavailability of 3 New Formulations of Premarin/MPA With Premarin/MPA (PREMPRO) Reference Formulation
Status: COMPLETED
Conditions: Estrogen Replacement Therapy
Interventions: DRUG: conjugated estrogens/progestin (MPA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Whole-Virion Inactivated SARS-CoV-2 Vaccine (BBV152) for COVID-19 in Healthy Volunteers
Status: COMPLETED
Conditions: COVID-19|SARS-CoV-2 Infection
Interventions: BIOLOGICAL: BBV152A - Phase I|BIOLOGICAL: BBV152B - Phase I|BIOLOGICAL: BBV152C - Phase I|BIOLOGICAL: Placebo - Phase I|BIOLOGICAL: BBV152A - Phase II|BIOLOGICAL: BBV152B - Phase II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cognitive Behavioural Therapy for Persons With MCI or Mild Dementia
Status: UNKNOWN
Conditions: Alzheimers' Disease
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating Autologous Endometrial Co-Culture Versus Conventional Medium in the Treatment of Infertility
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: Endometrial biopsy|OTHER: Autologous Endometrial Co-Culture|OTHER: Conventional media culture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety/Efficacy of Bromfenac Ophthalmic Solution for Ocular Inflammation and Pain Associated With Cataract Surgery
Status: COMPLETED
Conditions: Pain|Inflammation
Interventions: DRUG: bromfenac ophthalmic solution|DRUG: placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Immune Nephritis
Status: RECRUITING
Conditions: Immune Nephritis|Autoimmune Diseases|Lupus Nephritis
Interventions: BIOLOGICAL: Assigned Interventions CD19/BCMA CAR T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Botulinum Toxin Injection Combined With rESWT in Lower Extremity Spasticity in Children With Cerebral Palsy
Status: RECRUITING
Conditions: Cerebral Palsy, Spastic
Interventions: DEVICE: Radial Extracorporeal Shockwave Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effect of Chang'an I Recipe on Irritable Bowel Syndrome With Diarrhea
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Diarrhea
Interventions: DRUG: Chang'an I Recipe|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Food Effect of SYHA1402 in Healthy Subjects
Status: UNKNOWN
Conditions: Diabetic Peripheral Neuropathy
Interventions: DRUG: FE-SYHA1402 100mg|DRUG: SYHA1402-25mg|DRUG: Placebo-25mg|DRUG: SYHA1402-50mg|DRUG: Placebo-50mg|DRUG: SYHA1402-150mg|DRUG: Placebo-150mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CAR-T Cells in Systemic B Cell Mediated Autoimmune Disease
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus|Systemic Sclerosis|Dermatomyositis|Polymyositis
Interventions: DRUG: anti-CD19 CAR T cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STOP HCC: Mailed HCV Treatment Outreach Program for HCC Prevention for Elevated LFTs
Status: WITHDRAWN
Conditions: Hepatitis C|Hepatocellular Carcinoma
Interventions: BEHAVIORAL: Mailed Outreach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Post Market Clinical Follow-up Study for the Amvia/Solvia Pacemaker Family
Status: ACTIVE_NOT_RECRUITING
Conditions: Bradycardia|Heart Failure
Interventions: DEVICE: Amvia/Solvia pacemaker family
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Market Study Evaluating the Safety and Effectiveness of NuNec® Cervical Arthroplasty System
Status: TERMINATED
Conditions: Cervical Intervertebral Disc Degeneration
Interventions: DEVICE: NuNec Cervical Disc
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Silymarin (Milk Thistle Extract) in Treating Patients With Acute Lymphoblastic Leukemia Who Are Receiving Chemotherapy
Status: COMPLETED
Conditions: Drug/Agent Toxicity by Tissue/Organ|Leukemia
Interventions: DIETARY_SUPPLEMENT: silymarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for High Risk Stage II or Stage III Colon Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Capecitabine|DRUG: 5-Fluorouracil (5-FU)|DRUG: Leucovorin calcium|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Blockade of the Lumbar Plexus - the Supra Sacral Parallel Shift
Status: COMPLETED
Conditions: Hip Fracture
Interventions: PROCEDURE: Lumbar plexus block using LUT technique|PROCEDURE: Lumbar plexus block using SSPS technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Resynchronization Therapy Efficacy Enhancements
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Conducted AF Response (CAFR)|DEVICE: Conducted AF Response Plus (CAFRPlus)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Thymosin Beta 4 in Patients With Acute Myocardial Infarction.Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Low Dose|DRUG: Middle Dose|DRUG: High Dose|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fludrocortisone in Healthy Volunteers (AFLUCO4)
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Fludrocortisone 100 μg|DRUG: Fludrocortisone 200 μg|DRUG: Fludrocortisone 400 μg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Rintatolimod and IFN Alpha-2b for the Treatment of COVID-19 in Cancer Patients
Status: SUSPENDED
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm|Symptomatic COVID-19 Infection Laboratory-Confirmed
Interventions: OTHER: Best Practice|BIOLOGICAL: Recombinant Interferon Alfa-2b|DRUG: Rintatolimod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Study to Assess the Safety, Tolerability and Pharmacokinetics of NGM621 in Healthy Subjects, and to Assess the Safety, PK and Efficacy in Subjects With Moderate to Severe ARDS Caused by COVID-19
Status: TERMINATED
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: NGM621|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of Asthma Treatment Through Exhaled NO for Increased Asthma-Related Quality of Life (NOAK)
Status: COMPLETED
Conditions: Allergic Asthma
Interventions: DRUG: Single corticosteroid inhalers and Singulair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Collaborative Palliative and Leukemia Care Model for Patients With AML and MDS Receiving Non-Intensive Therapy
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: OTHER: Palliative Care|OTHER: Standard Leukemia care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Qi Gong as a Method of Craving Reduction in Severe Addict Patients
Status: UNKNOWN
Conditions: Alcohol Addiction|Alcohol Dependence
Interventions: OTHER: Qi Gong sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of MEK Inhibitor and PI3K/mTOR Inhibitor in Subjects With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Locally Advanced Solid Tumor|Metastatic Solid Tumor|Breast Cancer|Non Small Cell Lung Cancer|Melanoma|Colorectal Cancer
Interventions: DRUG: MSC1936369B (pimasertib)|DRUG: SAR245409 (PI3K and mTOR inhibitor)|DRUG: MSC1936369B (pimasertib)|DRUG: SAR245409 (PI3K and mTOR inhibitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Open Label Multicenter Study For Age Related Macular Degeneration Comparing PF-04523655 Versus Lucentis In The Treatment Of Subjects With CNV (MONET Study).
Status: COMPLETED
Conditions: Age Related Macular Degeneration
Interventions: DRUG: 0.5 mg ranibizumab|DRUG: 3 mg PF-04523655|DRUG: 1 mg PF-04523655
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot 3D Contrast-Enhanced Ultrasound Imaging to Predict Treatment Response in Liver Metastases
Status: COMPLETED
Conditions: Liver Metastases|Colon Cancer
Interventions: PROCEDURE: Dynamic contrast-enhanced ultrasound imaging|DEVICE: Optical Tracking Device|DEVICE: Electromagnetic Tracking Device|DRUG: Perflutren
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Modafinil and Naltrexone to Reduce Cocaine and Alcohol Dependence
Status: COMPLETED
Conditions: Alcohol-Related Disorders|Alcoholism|Cocaine-Related Disorders
Interventions: DRUG: Naltrexone|DRUG: Modafinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of iPS Cell-derived Cardiomyocyte Spheroids (HS-001) in Patients With Heart Failure (LAPiS Study)
Status: RECRUITING
Conditions: Heart Failure|Ischemic Heart Disease
Interventions: BIOLOGICAL: HS-001 CS|DEVICE: HS-001-D needle, HS-001-D Adaptor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Rituximab in Treating Patients With Newly Diagnosed AIDS-Related B-Cell Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: pegfilgrastim|BIOLOGICAL: rituximab|BIOLOGICAL: sargramostim|DRUG: cyclophosphamide|DRUG: pegylated liposomal doxorubicin hydrochloride|DRUG: prednisone|DRUG: vincristine sulfate|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relationship Between the Depth of Anesthesia and Auditory Evoked Potentials (P3a)
Status: RECRUITING
Conditions: General Anesthesia
Interventions: DEVICE: Electroencephalogram recording|OTHER: Auditory stimulation|DEVICE: Transcranial Doppler|DEVICE: Near-infrared spectroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Male Fertility Preservation Using Cryopreservation of Testicular Tissue Before Highly Gonadotoxic Cancer Treatment
Status: RECRUITING
Conditions: Childhood Cancer|Fertility Disorders
Interventions: PROCEDURE: testicular tissue biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Japanese Bridging Study of Autologous Muscle Derived Cells Compared to Placebo for Female Urinary Sphincter Repair(JPN1)
Status: WITHDRAWN
Conditions: Stress Urinary Incontinence
Interventions: BIOLOGICAL: AMDC-USR|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicentre, Open Label Phase IIIb/IV Study of Subcutaneously Administered Raptiva in the Treatment of Adult Subjects With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Candidates for Systemic Therapy for Psoriasis|Psoriasis
Interventions: DRUG: Efalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aflibercept Intravitreal Injection for Myopic Choroidal Neovascularization
Status: UNKNOWN
Conditions: Choroidal Retinal Neovascularization
Interventions: DRUG: Aflibercept Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Laser Application in Pain Management Following the Use of Orthodontic Elastomeric Separators
Status: COMPLETED
Conditions: Orthodontic Treatment
Interventions: RADIATION: Laser Irradiation One dose|RADIATION: Laser Irradiation Two doses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Logan Basic and Dysmenorrhea
Status: UNKNOWN
Conditions: Menstrual Distress (Dysmenorrhea)
Interventions: OTHER: No Intervention|PROCEDURE: Sham Logan Basic Adjustment|PROCEDURE: Logan Basic adjustment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy Followed by Stem Cell Transplant and Isotretinoin in Treating Young Patients With High-Risk Neuroblastoma
Status: UNKNOWN
Conditions: Neuroblastoma
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: dacarbazine|DRUG: doxorubicin hydrochloride|DRUG: etoposide phosphate|DRUG: ifosfamide|DRUG: isotretinoin|DRUG: melphalan|DRUG: topotecan hydrochloride|DRUG: vincristine sulfate|DRUG: vindesine|PROCEDURE: autologous hematopoietic stem cell transplantation|RADIATION: iobenguane I 131|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of Intrathecal Idursulfase-IT Administered in Conjunction With Elaprase® in Pediatric Patients With Hunter Syndrome and Early Cognitive Impairment
Status: COMPLETED
Conditions: Hunter Syndrome
Interventions: BIOLOGICAL: idursulfase-IT|OTHER: No IT treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Medical Clowning on Pain and Stress Level in Pediatric Patients Undergoing Hernia Repair Surgery LAUGH Study.
Status: COMPLETED
Conditions: Umbilical Hernia|Inguinal Hernia
Interventions: BEHAVIORAL: Medical Clown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION