pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Proof of Concept Pilot Trial of Alpha-1-Antitrypsin for Pre-Emption Of Steroid-Refractory Acute GVHD
Status: COMPLETED
Conditions: Graft-versus-host-disease|GVHD
Interventions: DRUG: Alpha 1-Antitrypsin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Association Between the Intraoperative Blood Pressure Changes and Whole Exome Genome
Status: NOT_YET_RECRUITING
Conditions: the Association Between the Arterial Stiffness, Intraoperative Blood Pressure Changes and Genetic Effect
Interventions: OTHER: this study did not involve interventions; it only observational study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Temozolomide and Procarbazine With Cilengitide for Patients With Glioblastoma Multiforme Without Methylation of the MGMT Promoter Gene
Status: UNKNOWN
Conditions: Newly Diagnosed Non Methylated Glioblastoma Multiforme Grade 4
Interventions: DRUG: Cilengitide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pomegranate and Hemodialysis Pilot Trial
Status: COMPLETED
Conditions: End Stage Renal Disease|Cardiovascular Disease|Inflammation
Interventions: OTHER: Pomegranate juice|OTHER: Pomegranate fruit extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: GnRH Agonist for Dual Trigger in IVF and for Luteal Phase Support in FET
Status: RECRUITING
Conditions: Subfertility
Interventions: DRUG: IVF: Decapeptyl and hCG|DRUG: FET: Decapeptyl|DRUG: IVF: hCG and normal saline|DRUG: FET: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Endovascular Plus GENe Therapy Versus Only EndoVascular Therapy for Severe Limb ischaemiA Trial
Status: RECRUITING
Conditions: Severe Lower Limb Ischemia
Interventions: DRUG: Deoxyribonucleic acid supercoiled plasmid pCMV-VEGF165 (Neovasculgen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab Plus Epacadostat vs Pembrolizumab Plus Placebo in Metastatic Non-Small Cell Lung Cancer (KEYNOTE-654-05/ECHO-305-05)
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Epacadostat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of D9421-C 9 mg in Patients With Active Crohn's Disease in Japan
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: D9421-C capsule 3 mg|DRUG: Mesalazine tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Understanding Perspectives of Frequently-Admitted Hospital Patients
Status: COMPLETED
Conditions: Continuity of Patient Care|High Utilizers of Hospital Care|Patient-Centered Care
Interventions: OTHER: CHAMP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Success of Indirect Pulp Capping: 1-Year Follow-Up
Status: COMPLETED
Conditions: Dentin, Carious|Indirect Pulp Capping
Interventions: PROCEDURE: indirect pulp capping with theracal pt|PROCEDURE: indirect pulp capping with therabase|PROCEDURE: indirect pulp capping with biodentine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Everolimus and Bevacizumab in Children With Recurrent Solid Tumors
Status: COMPLETED
Conditions: Recurrent or Refractory Solid Tumors|CNS Malignancies
Interventions: DRUG: Bevacizumab|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Brain Network by Simultaneous Dual-mode Stimulation in Subacute Stroke Patients
Status: COMPLETED
Conditions: Stroke|Motor Disorder
Interventions: DEVICE: rTMS on ipsilesional M1|DEVICE: tDCS on contralesional M1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Innovation Oncological Rehabilitation: Applicability of the Different Techniques Physiotherapeutic Post Breast Cancer
Status: UNKNOWN
Conditions: Lymphedema|Pain
Interventions: OTHER: Virtual reality|OTHER: Vibration therapy|OTHER: Hand cycling|OTHER: Canoeing|OTHER: Robotic rehabilitation|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetic Study of IT-141 in Monotherapy in Patients With Advanced Cancer
Status: TERMINATED
Conditions: Cancer|Neoplasms|Tumors|Refractory Solid Tumors|Recurrent Solid Tumors
Interventions: DRUG: IT-141
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strategy for Cardiovascular Disease Prevention Through Tailored Health Management in Individuals With Elevated Risk
Status: COMPLETED
Conditions: Cardiovascular Diseases|Risk Reduction|Primary Prevention
Interventions: COMBINATION_PRODUCT: Village doctor-led tailored health management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Early Regenerative Intervention for Post-Traumatic Osteoarthritis
Status: UNKNOWN
Conditions: Post-Traumatic Osteoarthritis of Knee
Interventions: COMBINATION_PRODUCT: ERIPTO Protocol|BIOLOGICAL: BMAC Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sutured Versus Cyanoacrylate Glue Mesh Fixation for Inguinal Hernia Repair
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: PROCEDURE: Cyanoacryale|PROCEDURE: Suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Serial Evaluation of Drug-Eluting Stents Using OCT (STRUT-OCT)
Status: TERMINATED
Conditions: Drug Eluting Stents (DES)|Percutaneous Coronary Intervention (PCI)|Uncovered and Malapposed Stent Struts|Optical Coherence Tomography (OCT)
Interventions: DEVICE: Drug-eluting stent implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Application of Standardized Cleaning and Disinfection Mode of HFT Surface in Hospital Infection Prevention and Control
Status: UNKNOWN
Conditions: Hospital Infection
Interventions: BEHAVIORAL: cleaning and disinfection mode for surfaces with high frequency contact|BEHAVIORAL: Routine procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trans-drain Occlusion for Postoperative Pancreatic Fistula- A Double Blind Randomized Clinical Trial
Status: COMPLETED
Conditions: Pancreatic Fistula
Interventions: PROCEDURE: Fistulography and trans-drain occlusion|PROCEDURE: Fistulography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Imaging to Assess Changes in Meniscus Vascularity
Status: UNKNOWN
Conditions: Meniscus Tears
Interventions: OTHER: Will undergo a single MRI assessment with intravenous dye|OTHER: pre and post surgery MRI scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Mobile Health Intervention for Family Smoking Cessation in Romania
Status: COMPLETED
Conditions: Telemedicine: Smoking Cessation App Only|Telemedicine: Smoking Cessation Counseling|Telemedicine: App + Counseling|Usual Care
Interventions: BEHAVIORAL: Smoke Free Together - App-only|BEHAVIORAL: Smoke Free Together - Telemedicine counseling only|BEHAVIORAL: Smoke Free Together - app + telemedicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pioglitazone and Insulin in Treating Subjects With Type 2 Diabetes Mellitus and Renal Failure.
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Pioglitazone and insulin|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ICVT in HPV-induced Genital Lesions of Immunocompromised and Immunocompetent Patients
Status: TERMINATED
Conditions: HPV-Induced Genital Lesions
Interventions: DRUG: CLS003|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotic Supplementation in Children Affected by Upper Respiratory Infections
Status: ACTIVE_NOT_RECRUITING
Conditions: Upper Respiratory Tract Infection
Interventions: DIETARY_SUPPLEMENT: Probiotic supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aromatherapy for Prevention of Intrathecal Morphine Induced Nausea and Vomiting
Status: COMPLETED
Conditions: Post Operative Nausea and Vomiting
Interventions: BIOLOGICAL: Peppermint essential oil|DRUG: Granisetron|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: AMIStem Primary Hip System Prospective Post-marketing Multi-centre Surveillance Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis|Arthritis|Avascular Necrosis|Fracture of the Femoral Neck or Head|Congenital Hip Dysplasia
Interventions: DEVICE: AMIStem Hip System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OCP vs Metformin on Ovarian Stromal Blood Flow in PCOS
Status: COMPLETED
Conditions: PCOS
Interventions: DRUG: Ethinyl Estradiol-cyprosterone acetate|DRUG: Metformin Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induced-T Cell Like NK Cellular Immunotherapy for Cancer Lack of MHC-I
Status: RECRUITING
Conditions: Anti-cancer Cell Immunotherapy|T Cell and NK Cell
Interventions: BIOLOGICAL: ITNK cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Copanlisib and Rituximab in Relapsed Indolent B-cell Non-Hodgkin's Lymphoma (iNHL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma,Non-Hodgkin
Interventions: DRUG: Copanlisib (Aliqopa, BAY80-6946)|DRUG: Placebo|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Transmission of Bacteria That Cause Cavities From Mothers to Their Children
Status: COMPLETED
Conditions: Caries, Dental
Interventions: DRUG: Cervitec chlorhexidine varnish|DRUG: Duraphat fluoride varnish|DRUG: xylitol gum from Fennobon, Finland
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Selective Effect of Foam Rolling and Manual Massage
Status: COMPLETED
Conditions: Health Behavior|Health, Subjective|Health Knowledge, Attitudes, Practice
Interventions: OTHER: Psychometric ratings (Likert-scale)|BEHAVIORAL: Range of motion measures|BEHAVIORAL: Mental calculation task|DEVICE: Resting-state electroencephalography|DEVICE: Resting-state galvanic skin resistance measures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Safety, Tolerability and Pharmacodynamics Study of ACE-011 (ActRIIA-IgG1) in Healthy Postmenopausal Women
Status: COMPLETED
Conditions: Osteoporosis
Interventions: BIOLOGICAL: ACE-011 or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Corticosteroids Alone Versus Corticosteroids and Extracorporal Photopheresis (ECP) as First-line Treatment of Standard II Acute Graft-versus-host Disease
Status: UNKNOWN
Conditions: Acute-graft-versus-host Disease
Interventions: COMBINATION_PRODUCT: Methoxsalen + ECP device|DRUG: Corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Food With Mirabegron in Healthy Chinese Participants
Status: COMPLETED
Conditions: Pharmacokinetics of Mirabegron|Food Effect|Healthy Chinese Subjects
Interventions: DRUG: mirabegron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: MULTIple Doses of IPTi Proposal: a Lifesaving High Yield Intervention
Status: RECRUITING
Conditions: Malaria
Interventions: DRUG: Intermittent preventive treatment of malaria in infants (IPTi) with sulfadoxine-pyrimethamine (SP)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Magnetic Resonance Imaging Study of Lisdexamfetamine for Bipolar Depression
Status: TERMINATED
Conditions: Bipolar Depression
Interventions: DRUG: Lisdexamfetamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effectiveness of 5-Azacitidine and Bevacizumab in Advanced Renal Cell Carcinoma
Status: TERMINATED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Bevacizumab|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata
Status: RECRUITING
Conditions: Alopecia Areata
Interventions: DRUG: Upadacitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Geniculate Nerve Ablation vs Geniculate Artery Embolization vs Sham for Knee Osteoarthritic Pain
Status: WITHDRAWN
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: Geniculate artery embolization|PROCEDURE: Geniculate nerve ablation|PROCEDURE: Skin infiltration of local anesthetic at groin and knee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Concurrent vs. Sequential Cessation of Dual Cigarette and E-cigarette Use
Status: RECRUITING
Conditions: Cigarette Smoking|E-Cigarette Use|Smoking Cessation
Interventions: DRUG: Varenicline|BEHAVIORAL: Counseling|BEHAVIORAL: Guided Self-Change Booklets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase II Trial of EVEROLIMUS ± Trastuzumab in Hormone-Refractory Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Everolimus|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study on HIV-related Hodgkin Lymphoma
Status: UNKNOWN
Conditions: HIV-associated Hodgkin Lymphoma
Interventions: DRUG: Doxorubicin|DRUG: Bleomycin|DRUG: Vinblastine|DRUG: Dacarbazine|DRUG: Etoposide|DRUG: Cyclophosphamide|DRUG: Vincristine|DRUG: Procarbazine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exosomal microRNAs as a Biomarker in Panic Disorder and in Response to CBT
Status: UNKNOWN
Conditions: Panic Disorder
Interventions: BEHAVIORAL: CBT- both internet and face to face|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Administration of Hydroxychloroquine (Plaquenil) to African Americans and Hispanics for the Treatment of Mild to Severe Ulcerative Colitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Ulcerative Colitis (Disorder)
Interventions: DRUG: Hydroxychloroquine|DRUG: Mesalamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Iron-deficiency Anaemia and Its Impact on Recovery After Colorectal Cancer Surgery
Status: NOT_YET_RECRUITING
Conditions: Iron Deficiencies|Iron Deficiency Anaemia|Postoperative Complications|Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: Laboratory analyses for the detection of iron deficiency anaemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pictorial Warning Labels and Memory for Cigarette Health-risk Information Over Time
Status: COMPLETED
Conditions: Smoking Cessation|Smoking, Cigarette
Interventions: BEHAVIORAL: Text-only PWL|BEHAVIORAL: Low-emot PWL|BEHAVIORAL: High-emot PWL|BEHAVIORAL: Immediate posttest|BEHAVIORAL: delay posttest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: |Primary Purpose: PREVENTION
Clinical trial: Pilates-based Cardiopulmonary Physical Therapy for In-Patients After Cardiac Surgery
Status: UNKNOWN
Conditions: Other Functional Disturbances Following Cardiac Surgery
Interventions: BEHAVIORAL: Pilates-based CPT|BEHAVIORAL: Traditional CPT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Turning Dexmedetomidine Into a Powerful Anesthetic That Can be Rapidly and Completely Reversed
Status: WITHDRAWN
Conditions: Emergence From Anesthesia
Interventions: DRUG: Atipamezole & Caffeine|DRUG: Dexmedetomidine Hydrochloride & Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
Status: RECRUITING
Conditions: Mitochondrial Disorders|Mitochondrial Genetic Disorders|Mitochondrial Diseases|Disorder of Mitochondrial Respiratory Chain Complexes|Deletion and Duplication of Mitochondrial DNA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Post Extraction Changes Following Ridge Preservation Using Partially Demineralized Dentin Block Versus Xenograft
Status: RECRUITING
Conditions: Socket Preservation
Interventions: BIOLOGICAL: Partially Demineralized Dentin Block|BIOLOGICAL: Xenograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of 7 Days Versus 14 Days of Antibiotic Therapy for Acute Pyelonephritis in Kidney Transplant Recipients, a Multicentre Randomized Non-inferiority Trial.
Status: RECRUITING
Conditions: Pyelonephritis Acute|Kidney Transplant Infection
Interventions: DRUG: Short antibiotic treatment|DRUG: Usual antibiotic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cisplatin, Etoposide, and Bevacizumab in Treating Patients With Previously Untreated Extensive Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Extensive Stage Small Cell Lung Cancer
Interventions: DRUG: cisplatin|DRUG: etoposide|BIOLOGICAL: bevacizumab|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous T Cells With or Without Cyclophosphamide and Fludarabine in Treating Patients With Recurrent or Persistent Advanced Ovarian Epithelial Cancer, Primary Peritoneal Cavity Cancer, or Fallopian Tube Cancer (Fludarabine Treatment Closed as of 12/01/2009)
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: therapeutic autologous lymphocytes|DRUG: cyclophosphamide|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA
Status: COMPLETED
Conditions: Sciatica Acute|Sciatica
Interventions: DRUG: Lacosamide 50 MG Oral Tablet [Vimpat]|DRUG: Codeine Phosphate|DRUG: Diclofenac Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Glucose Oxidase as Treatment Against Common Cold
Status: COMPLETED
Conditions: Common Cold
Interventions: DRUG: Glucose oxidase + glucose|DRUG: Saline+glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Sasanlimab With Radiation as an in Situ Vaccine for Cisplatin-ineligible Muscle Invasive Bladder Cancer
Status: RECRUITING
Conditions: Urothelial Carcinoma Bladder
Interventions: DRUG: Sasanlimab|RADIATION: Stereotactic Body Radiation Therapy|PROCEDURE: Radical Cystectomy + pelvic lymph node dissection + urinary diversion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Multicomponent Exercise Program on Functional Capacity in Frail Aged Participants With Cognitive Decline
Status: UNKNOWN
Conditions: Frail Elderly Syndrome|Cognitive Impairment
Interventions: BEHAVIORAL: VIVIFRAIL multicomponent exercise training program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Right Atrial Ectopy Triggering Ganglionated Plexuses in AF
Status: RECRUITING
Conditions: Cardiac Arrhythmia|Atrial Fibrillation
Interventions: PROCEDURE: Right Atrial ganglionated plexus ablation|DIAGNOSTIC_TEST: Holter Monitor|PROCEDURE: Pulmonary vein isolation|PROCEDURE: Right cavo-tricuspid and left roof linear ablation|DIAGNOSTIC_TEST: Personal ECG recordings|OTHER: Quality of life questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Estimation of the Effect of Multiple Dose Ritlecitinib (PF-06651600) on the Pharmacokinetics of a Single Dose of Caffeine in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Caffeine|OTHER: Ritlecitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bovine Milk Oligosaccharide Study
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Bovine Milk Oligosaccharide|DIETARY_SUPPLEMENT: Placebo Glucose Polymer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treatment Strategy in Patients With High-risk of Postextubation Distress in ICU Based on a Lung Ultrasound Score Versus Standard Strategy
Status: COMPLETED
Conditions: Adult Patients Ventilated More Than 48 h
Interventions: DEVICE: lung ultrasound score
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Complex Decongestive Therapy (CDT) in Patients With Venous Insufficiency: a Experimental Study
Status: RECRUITING
Conditions: Lymphatic Edema|Cellulitis of Leg|Vein Disease
Interventions: OTHER: Complex Decongestive Therapy (CDT) in venous insufficiency,
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Veliparib With or Without Mitomycin C in Treating Patients With Metastatic, Unresectable, or Recurrent Solid Tumors
Status: COMPLETED
Conditions: Solid Neoplasm
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Mitomycin|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PNU-100480 In Newly Diagnosed, Drug Sensitive Patients With Pulmonary TB; Early Bactericidal Activity; Whole Blood Assay
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: PNU-100480|DRUG: PNU-100480|DRUG: RHZE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Finding Study Of Oral Eltrombopag In Patients With Sarcoma Receiving Adriamycin And Ifosfamide
Status: COMPLETED
Conditions: Thrombocytopaenia
Interventions: DRUG: eltrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Efficacy and Safety of Erenumab (AMG 334) in Migraine Prevention
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Erenumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: mHealth Physical Activity Trial for Older HIV-infected Adults (mFIT)
Status: COMPLETED
Conditions: HIV
Interventions: OTHER: Digital Activity Tracker|OTHER: Smart Text Messaging|OTHER: Physical Activity Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vedolizumab, Anti-CD25 Antibody, Rapid Reduction of Glucocorticoids for SR-aGVHD With Gastrointestinal Involvement
Status: RECRUITING
Conditions: Safety and Efficacy
Interventions: DRUG: Basiliximab|DRUG: Vedolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin for Pulmonary Hypertension HFpEF
Status: RECRUITING
Conditions: Pulmonary Hypertension|Heart Failure
Interventions: DRUG: Metformin|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Early Enteral vs. Parenteral Nutrition on Preservation of Gut Mucosa Integrity in Patients Requiring Mechanical Ventilation and Catecholamine
Status: TERMINATED
Conditions: Acute Respiratory Failure|Shock
Interventions: OTHER: Parenteral nutrition|OTHER: Enteral Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Enteral Feeding in Discharged Patients
Status: TERMINATED
Conditions: Surgical Resection of an Upper Gastrointestinal Malignancy|Nutritional Supplementation Via a Jejunostomy Post Discharge From Hospital
Interventions: DIETARY_SUPPLEMENT: Jejunal feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of a Needle-free Injection Method With a Needle-syringe Injection Method
Status: COMPLETED
Conditions: Growth Hormone Deficiency
Interventions: DEVICE: T-jet® containing TevTropin®|PROCEDURE: TevTropin® needle-syringe injection method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the MAGNITUDE® Bioresorbable Drug-Eluting Scaffold in the Treatment of Patients With Below the Knee Disease in Australia
Status: RECRUITING
Conditions: Critical Limb-Threatening Ischemia|Critical Limb Ischemia|Critical Lower Limb Ischemia
Interventions: DEVICE: MAGNITUDE BRS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Food Study of Midodrine HCl Tablets 5 mg and ProAmatine® Tablets 5 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Midodrine HCl Tablets 5 mg|DRUG: ProAmatine® Tablets 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical and Biological Effects of Anti-IgE (Omalizumab) in Patients With Bilateral Nasal Polyposis and Asthma
Status: COMPLETED
Conditions: Nasal Polyposis|Asthma
Interventions: DRUG: Omalizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin A in the Treatment of Hemifacial Spasm
Status: UNKNOWN
Conditions: Hemifacial Spasm
Interventions: DRUG: Botulinum Toxin Type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Intravenous Infusion Plasma in Amyotrophic Lateral Sclerosis
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: BIOLOGICAL: Plasma from healthy young people treatment + Riluzole|DRUG: Riluzole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy, Safety, and Tolerability of IMU-838 in Patients With Progressive Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: IMU-838|DRUG: Placebo matching IMU-838
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Single Administration Post-exposure Prophylaxis Treatment for Marburg Virus
Status: COMPLETED
Conditions: Marburg Hemorrhagic Fever
Interventions: DRUG: AVI-6003|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The LEAD COVID-19 Trial: Low-risk, Early Aspirin and Vitamin D to Reduce COVID-19 Hospitalizations
Status: WITHDRAWN
Conditions: COVID|Vitamin D Deficiency|Coagulopathy|Disseminated Intravascular Coagulation
Interventions: DRUG: Aspirin 81 mg|DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Index of Microcirculatory Resistance to Evaluate Myocardial Protection After Ischemic Adaptation
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: PROCEDURE: IPC+PCI|PROCEDURE: No IPC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Influence of Menstrual Cycle Stages on Female Athletes
Status: COMPLETED
Conditions: Menstrual Cycle|Sports
Interventions: PROCEDURE: Determination of hormone level concentrations|PROCEDURE: Jump height determination|PROCEDURE: Grip strength determination|PROCEDURE: Flexibility determination|PROCEDURE: Indirect maximum oxygen consumption determination|DEVICE: Sensory and pain threshold determination|OTHER: Physical and mental symptoms associated with the menstrual cycle|DEVICE: Daily activity|PROCEDURE: Biochemical parameters determination|PROCEDURE: Blood count determination|PROCEDURE: Body composition parameters determination|PROCEDURE: Vital signs|OTHER: Checking for correct use of contraceptive methods|PROCEDURE: Urinary LH determination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cyclosporine Eye Drops in Preventing Graft-Versus-Host Disease of the Eye in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer or Bone Marrow Failure Disorder
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: DRUG: cyclosporine ophthalmic emulsion|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: First- Line Treatment With Durvalumab Plus XELOX Chemotherapy in Advanced Gastrointestinal Neuroendocrine Carcinoma
Status: RECRUITING
Conditions: Gastrointestinal Neuroendocrine Carcinoma
Interventions: DRUG: Durvalumab and Chemotherapy(oxaliplatin and capecitabine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vascular Benefits of Adding CarvedilolCR to Type2 Diabetic Patients on ACEI.
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2|Hypertension
Interventions: DRUG: Carvedilol Controlled Release (CR)|DRUG: lisinopril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Salpingectomy Versus Aspiration of Hydrosalpingeal Fluid Prior to IVF-ET
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: Needle aspiration of hydrosalpinx|PROCEDURE: Salpingectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Placebo Controlled Trial of Dalfampridine ER for Ambulatory Activity in People With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: dalfampridine ER|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoantigen DNA Vaccine Alone vs. Neoantigen DNA Vaccine Plus Durvalumab in Triple Negative Breast Cancer Patients Following Standard of Care Therapy
Status: TERMINATED
Conditions: Triple Negative Breast Cancer|Triple Negative Breast Neoplasms|TNBC - Triple-Negative Breast Cancer|Triple-negative Breast Carcinoma
Interventions: DRUG: Durvalumab|BIOLOGICAL: Neoantigen DNA vaccine|DEVICE: TDS-IM system (Inchor Medical Systems)|PROCEDURE: Peripheral blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Finding Study of KRN321(Darbepoetin Alfa) for the Treatment of Anemia in Subjects With Solid Tumor
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Telerehabilitation Modalities in Physical Therapy in the Management of Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: telerehabilitation and physical therapy|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ORBITAL: Open-Label Primary Care Study: Rosuvastatin Based Compliance Initiatives Linked To Achievement Of LDL Goals
Status: WITHDRAWN
Conditions: Primary Hypercholesterolaemia
Interventions: DRUG: Rosuvastatin|PROCEDURE: Initiatives to improve compliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anchorsure Versus Capio for Sacrospinous Ligament Fixation
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DEVICE: Capio Slim Device|DEVICE: Anchorsure Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Camrelizumab Plus R-CHOP Regimen in Untreated Primary Extranodal DLBCL
Status: NOT_YET_RECRUITING
Conditions: Primary Extranodal Lymphoma|DLBCL
Interventions: DRUG: Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Antacid on Bioavailability of Febuxostat After Administration of a Febuxostat 80 mg Extended-Release Capsule
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Febuxostat XR|DRUG: Maalox Advance Regular Strength liquid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of 2 Different Vaccination Schedules of Rabies and Japanese Encephalitis Vaccines in Healthy Adult Subjects
Status: COMPLETED
Conditions: Rabies|Japanese Encephalitis
Interventions: BIOLOGICAL: Rabies|BIOLOGICAL: Japanese Encephalitis|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Investigation of the 24 Hour Forced Expiratory Flow in 1 Second (FEV1) Profile of a Single Dose of Indacaterol/Mometasone Delivered Via the TWISTHALER® Device in Adult Patients With Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: fluticasone propionate/salmeterol|DRUG: indacaterol maleate / mometasone furoate|DRUG: placebo to indacaterol/mometasone|DRUG: placebo to fluticasone propionate/salmeterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Adjunctive Pimavanserin in Major Depressive Disorder (CLARITY)
Status: COMPLETED
Conditions: Adjunctive Treatment of Major Depressive Disorder
Interventions: DRUG: Pimavanserin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Falls Prevention Through Physical And Cognitive Training in Mild Cognitive Impairment
Status: UNKNOWN
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Physical and Cognitive Training|BEHAVIORAL: Physical Training|BEHAVIORAL: Cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Repurposing alpha1 Noradrenergic Antagonists for Alcoholism Treatment
Status: COMPLETED
Conditions: Alcoholism
Interventions: DRUG: Prazosin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Continuation Study With Budesonide Oral Suspension (BOS) for Adolescent and Adult Participants With Eosinophilic Esophagitis (EoE)
Status: TERMINATED
Conditions: Eosinophilic Esophagitis (EoE)
Interventions: DRUG: Budesonide oral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Motorized Spiral Enteroscopy Vs Single Balloon Enteroscopy In Patients With Small Bowel Disorders- A RCT
Status: COMPLETED
Conditions: Small Bowel Disease
Interventions: DEVICE: Novel Motorized Spiral Enteroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: PFA for Paroxysmal Atrial Fibrillation
Status: ACTIVE_NOT_RECRUITING
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: Pulsed electric field ablation device;Cardiac Pulsed Electric Field Ablation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Automated Graduated CPAP (AGPAP) for Improved Adherence in Newly Diagnosed Obstructive Sleep Apnea (OSA) Patients
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: REMstar Auto A-Flex|DEVICE: modified REMstar Auto A-Flex with AGPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Hemodynamic Changes by Using the Videolaryngoscope and the Macintosh Laryngoscope
Status: COMPLETED
Conditions: Anesthesia Intubation Complication
Interventions: DEVICE: videolaryngoscope|DEVICE: Macintosh laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The PK Characteristics of the Co-administration of Rosuvastatin and Telmisartan/Amlodipine and JLP-1401 in Healthy Male Volunteers Volunteers
Status: COMPLETED
Conditions: Hypertension With Dyslipidemia
Interventions: DRUG: JLP-1401|DRUG: Telmisartan/Amlodipine, Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Immunogenicity of an Inactivated Whole-cell Pneumococcal Vaccine Gamma-PN3.
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: Gamma-PN3|BIOLOGICAL: Prevenar-13|BIOLOGICAL: Pneumovax-23|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Aclidinium Bromide/Formoterol Fumarate Compared With Formoterol Fumarate in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Aclidinium Bromide/Formoterol Fumarate|DRUG: Formoterol Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Functional Foods on Gut Microbiota in Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: DP|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RESILIENCE Trial: Evaluation of the Durability of Aortic Bioprostheses/Valves With RESILIA Tissue in Subjects Under 65
Status: TERMINATED
Conditions: Aortic Valve Replacement
Interventions: DIAGNOSTIC_TEST: Subjects previously implanted with a RESILIA aortic tissue valve.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tafasitamab and Rituximab for Front-Line Treatment of Post-Transplant Lymphoproliferative Disorder
Status: RECRUITING
Conditions: Monomorphic B-Cell Post-Transplant Lymphoproliferative Disorder|Polymorphic Post-Transplant Lymphoproliferative Disorder
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Positron Emission Tomography|BIOLOGICAL: Rituximab|BIOLOGICAL: Tafasitamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Financial Navigation Program for Improving Financial Toxicity Among Breast Cancer in China
Status: RECRUITING
Conditions: Breast Neoplasm Female|Financial Toxicity|Financial Navigation
Interventions: BEHAVIORAL: Financial Navigation|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Decreased Empathy and Emotion Recognition in Patients With Neurodegenerative Disease
Status: UNKNOWN
Conditions: Neuro-Degenerative Disease|Dementia|Caregiver Burnout|Alzheimer Disease|Frontotemporal Lobar Degeneration|Parkinson Disease|Vascular Dementia
Interventions: BEHAVIORAL: Educational Brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Standard Therapy Given With or Without Combination Chemotherapy in Treating Patients With Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: ifosfamide|DRUG: mitomycin C|DRUG: vinblastine sulfate|DRUG: vindesine|DRUG: vinorelbine tartrate|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Atrial Fibrillation in Relationship to Sleep Quality and Plasma Biomarkers
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DIAGNOSTIC_TEST: ECHOcardiography|DIAGNOSTIC_TEST: Peripheral blood samples for plasmatic biomarkers|DIAGNOSTIC_TEST: Athens insomnia scale questionnaire|DIAGNOSTIC_TEST: ECG Holter monitor|DIAGNOSTIC_TEST: ECG event recorder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p