pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Cobimetinib for BRAF-wild-type or Mutated Histiocytoses
Status: COMPLETED
Conditions: Disease or R Group Histiocytoses
Interventions: DRUG: Cobimetinib|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cone Beam Computed Tomography (CT) (CBCT) With and Without a Customized Vacuum Immobilization Device (CVID)
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DEVICE: prone pillow and simple ankle fixation device|DEVICE: Customized Vacuum Immobilization Device (CVID)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnesium and Ketamine in Postoperative Analgesia
Status: COMPLETED
Conditions: Postoperative Analgesia
Interventions: DRUG: Ketamine|DRUG: ketamine and magnesium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Extended Therapy of PEGASYS (Peginterferon Alfa-2a) in Combination With COPEGUS (Ribavirin) in Patients With Chronic Hepatitis C and Slow Response
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: COPEGUS|DRUG: peginterferon alfa-2a [Pegasys]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving the Quality of Radiotherapy by Multi-Institution Knowledge-Based Planning Optimization Models (Acronym: MIKAPOCo, Multi-Institutional Knowledge-based Approach in Plan Optimization for the Community)
Status: ENROLLING_BY_INVITATION
Conditions: Breast Cancer|Prostate Cancer
Interventions: OTHER: treatment plan comparison
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: WALANT Procedure in Carpal Tunnel Release
Status: COMPLETED
Conditions: Carpal Tunnel|Median Nerve Neuralgia|Anesthesia, Local
Interventions: PROCEDURE: Experimental: WALANT procedure|PROCEDURE: Active Comparator: Axial ALR|PROCEDURE: Active Comparator: Truncal ALR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Aerobic Cycling Training in Patients With Gynecologic Cancer-related Lower Extremity Lymphedema
Status: COMPLETED
Conditions: Lymphedema|Lymphedema, Lower Limb|Gynecologic Cancer
Interventions: OTHER: Aerobic Exercise|OTHER: Complete Decongestive Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of 23-Valent Pneumococcal Polysaccharide Vaccine in Healthy Volunteers Aged 2 Years and Above
Status: COMPLETED
Conditions: Pneumonia, Pneumococcal
Interventions: BIOLOGICAL: 23-Valent Pneumococcal Polysaccharide Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Pharmacist Intervention on Disease Knowledge, Rehabilitation and Medication Adherence, Treatment Induced Direct Cost, Health-related Quality of Life and Satisfaction in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Pharmaceutical Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Palliative Management of Inoperable Malignant Bowel Obstruction
Status: TERMINATED
Conditions: Malignant Bowel Obstruction
Interventions: DRUG: Dexamethasone|DRUG: Metoclopramide|DRUG: Octreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Taper-shaped Cuff Endotracheal Tube Against Respiratory Infections
Status: COMPLETED
Conditions: Postoperative Pneumonia
Interventions: DEVICE: Endotracheal tube TaperGuard|DEVICE: Endotracheal tube Hi-Contour Brandt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of Low-Dose Ondansetron For Adjunctive Therapy In Adult Patients With Obsessive-Compulsive Disorder
Status: TERMINATED
Conditions: Obsessive-compulsive Disorder
Interventions: DRUG: Ondansetron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Infusion Versus Bolus Dosing for Pain Control After Pediatric Cardiothoracic Surgery
Status: COMPLETED
Conditions: Congenital Heart Disease
Interventions: DRUG: continuous infusion|DRUG: as needed dosing|DRUG: Acetaminophen|DRUG: ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Soquelitinib vs Standard of Care in Participants With Relapsed/Refractory Peripheral T-cell Lymphoma Not Otherwise Specified, Follicular Helper T-cell Lymphomas, or Systemic Anaplastic Large-cell Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Peripheral T-Cell Lymphoma, Not Otherwise Specified|Angioimmunoblastic T-cell Lymphoma|Follicular T-Cell Lymphoma|Nodal Peripheral T-Cell Lymphoma With TFH Phenotype|Systemic Anaplastic Large Cell Lymphoma|Lymphoma, T-Cell, Peripheral|Lymphoma, T-Cell
Interventions: DRUG: Soquelitinib|DRUG: Belinostat|DRUG: Pralatrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of TRM-1 (TRAIL-R1 Monoclonal Antibody) in Subjects With Relapsed or Refractory Non-Hodgkin's Lymphoma (NHL)
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: TRAIL-R1 mAb (TRM-1; HGS-ETR1)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic-pharmacodynamic Dose Comparison Study of 8 mg/kg of Inhaled or Parenteral Gentamicin in 12 Mechanically Ventilated Critically Ill Patients Treated for Ventilator-associated Pneumonia
Status: COMPLETED
Conditions: Ventilator-associated Pneumonia
Interventions: DRUG: gentamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label, Prospective, Multicenter Study to Evaluate the Cutera Excel V™ Laser and a Micro-Lens Array Attachment
Status: COMPLETED
Conditions: Scarring|Skin Aging
Interventions: DEVICE: Excel V™ Laser & Micro-Lens Array Attach
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Physical Activity and Fibrosing Interstitial Lung Disease
Status: NOT_YET_RECRUITING
Conditions: Fibrotic Interstitial Lungs Diseases
Interventions: OTHER: Training on eccentric ergocycle|OTHER: Training on concentric ergocycle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Usefulness to Doctors of the Risperdal Consta Treatment Guidebook Over a Three-month Period During Which Adult Patients With Schizophrenia or Schizoaffective Disorder Are Switching From Daily Doses or Risperidone Tablets to Long-acting Risperidone by Injection
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders
Interventions: DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UHCDS a-tDCS + TE in Fibromyalgia Patients
Status: NOT_YET_RECRUITING
Conditions: Fibromyalgia
Interventions: DEVICE: Real UHCDS a-tDCS|DEVICE: Sham UHCDS a-tDCS|DEVICE: Therapeutic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rate of Tranexamic Acid Administration on Blood Pressure (RateTXA) Study.
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: Tranexamic Acid (TXA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Endoscopic Resection of Early Esophageal Tumors in the Context of Cirrhosis or Portal Hypertension
Status: COMPLETED
Conditions: Esophageal Neoplasms|Cirrhosis|Portal Hypertension
Interventions: PROCEDURE: Endosocpic resection of early esophageal tumor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Plexin B2 Gene Expression and Polymorphisms in Psoriasis
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: RADIATION: Narrow band Ultraviolet B phototherapy group|DRUG: Acitretin group|COMBINATION_PRODUCT: Acitretin plus Narrow band Ultraviolet B phototherapy group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Biobehavioral Physical Therapy Strategies Based on Therapeutic Exercise Applied to Chronic Migraine Patients
Status: COMPLETED
Conditions: Chronic Migraine|Chronic Headache
Interventions: BEHAVIORAL: Therapeutic patient education|OTHER: Therapeutic exercise|OTHER: No intervention|OTHER: Manual Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Sugemalimab (or Placebo) Plus PGemOx Regimen in Participants With Extranodal NK/T-Cell Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Extranodal NK/T-cell Lymphoma
Interventions: BIOLOGICAL: Sugemalimab|DRUG: Placebo|DRUG: Pegaspargase|DRUG: Gemcitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Jaktinib on QT/QTc Interval in Healthy Participants
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: Jaktinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of Emicizumab in Participants With Mild or Moderate Hemophilia A Without FVIII Inhibitors
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild Hereditary Factor VIII Deficiency Disease Without Inhibitor|Moderate Hereditary Factor VIII Deficiency Disease Without Inhibitor|Hemophilia A
Interventions: DRUG: Emicizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of SKLB1028 in Subjects With Relapsed/Refractory Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: SKLB1028
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comorbidity Screening and Referral by Prosthetists
Status: COMPLETED
Conditions: Limb Ischemia|Low Back Pain|Depression|Neuropathy;Peripheral|Amputation
Interventions: OTHER: Standard-of-Care|OTHER: Clinical Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Sequential Treatment With Ponatinib and Blinatumomab vs Chemotherapy and Imatinib in Newly Diagnosed Adult Ph+ ALL
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia (Philadelphia Chromosome Positive)|ALL, Adult|Philadelphia-Positive ALL
Interventions: DRUG: Ponatinib + Blinatumomab|DRUG: Chemotherapy + Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Graptopetalum Paraguayense E. Walther on the Oxidative Stress, Antioxidant Enzyme Activity and Inflammation in Subjects With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: OTHER: Graptopetalum paraguayense E. Walther|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial to Evaluate Drug-drug Interactions Between Darunavir/Cobicistat and Etravirine in Hiv- Infected Patients
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: darunavir/cobicistat|DRUG: etravirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacokinetic, Safety, and Tolerability Study of Intranasally Administered Esketamine in Elderly and and Healthy Younger Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Esketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Direct Antiviral Therapy on Hepatitis c Virus-related Thrombocytopenia
Status: UNKNOWN
Conditions: Hepatitis C
Interventions: DRUG: sofosbuvir daclatasvir|DRUG: Ledipasvir/sofosbuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of the Cytrellis Micro-Coring Device for the Treatment of Moderate to Severe Facial Wrinkles
Status: UNKNOWN
Conditions: Wrinkle
Interventions: DEVICE: MCD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of HMPL-523+Azacitidine in Elderly Patients With Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: HMPL-523|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Dose Optimization of Amikacin Guided by Pharmacokinetic Modeling Software in Patients With Septic Shock
Status: COMPLETED
Conditions: Shock, Septic
Interventions: OTHER: Amikacin dose optimization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate How Tamsulosin (at 1 Dose) and Solifenacin (at 2 Different Doses) Are Taken up From the Intestine, Distributed Through the Body and Eliminated From the Body When Administered in Combination as a Single Tablet (Called EC905)
Status: COMPLETED
Conditions: EC905|Pharmacokinetics|Multiple Dose|Healthy Subjects
Interventions: DRUG: EC905
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gemcitabine and Split-dose Cisplatin (GC) Plus Sorafenib in Chemotherapy-naïve Patients With Locally Advanced or Metastatic Urothelial Carcinoma
Status: TERMINATED
Conditions: Bladder Cancer|URINARY BLADDER
Interventions: DRUG: gemcitabine and cisplatin plus sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TIMING of Oral Anticoagulant Therapy in Acute Ischemic Stroke With Atrial Fibrillation
Status: COMPLETED
Conditions: Ischemic Stroke|Atrial Fibrillation
Interventions: OTHER: Early start of NOAC|OTHER: Late start of NOAC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Predictive Factors of Obesity-hypoventilation Syndrome (OHS) Among Obese Subjects- ETUDE COHYPOB -
Status: TERMINATED
Conditions: Obesity-hypoventilation Syndrome|Nocturnal Alveolar Hypoventilation
Interventions: OTHER: Annual visits among 3 years. During each visit different testings are performed in order to detect an obesity-hypoventilation syndrome (OHS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: NY-ESO-1-redirected CRISPR (TCRendo and PD1) Edited T Cells (NYCE T Cells)
Status: TERMINATED
Conditions: Multiple Myeloma|Melanoma|Synovial Sarcoma|Myxoid/Round Cell Liposarcoma
Interventions: BIOLOGICAL: NY-ESO-1 redirected autologous T cells with CRISPR edited endogenous TCR and PD-1|DRUG: Cyclophosphamide|DRUG: Fludarabine|DEVICE: NY-ESO-1 expression testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Probiotic Therapy in the Treatment of Periodontitis.
Status: COMPLETED
Conditions: Periodontitis|Probiotics
Interventions: PROCEDURE: Scaling root planning|DIETARY_SUPPLEMENT: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: SREBF1 Polymorphism and Egg Yolk on Cardiovascular Disease Risk in Healthy Young Adults: a Randomised, Two-period, Single Blinded, Crossover Trial
Status: SUSPENDED
Conditions: Healthy|GEN1 Gene Mutation
Interventions: DIETARY_SUPPLEMENT: Egg yolks|DIETARY_SUPPLEMENT: Macronutrients equivalent control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial to Evaluate Efficacy and Safety of the Combination Therapy of Genexol®-PM Plus Carboplatin® Compared to Genexol® Plus Carboplatin® as a Firstline Treatment in Subjects With Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Genexol®-PM 260mg/m2 plus Carboplatin 5 AUC|DRUG: Genexol® 175mg/m2 plus Carboplatin 5 AUC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Conversion Treatment of HAIC Combined With Camrelizumab and Apatinib for Unresected Hepatocellular Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of the MiStent Drug Eluting Stent (DES) in Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: MiStent DES|DEVICE: Endeavor DES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mini-PCNL Versus Standard-PCNL For The Management of 20-40 mm Size Kidney Stones
Status: COMPLETED
Conditions: Kidney Calculi
Interventions: PROCEDURE: Mini Percutaneous Nephrolithotomy|PROCEDURE: Percutaneous Nephrolithotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Of Impetigo With Topical SB-275833 Ointment, 1% Versus Topical Placebo Ointment
Status: COMPLETED
Conditions: Impetigo
Interventions: DRUG: SB-275833 ointment, 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Role of Stress Neuromodulators in Decision Making Under Risk (Part II)
Status: COMPLETED
Conditions: Stress
Interventions: DRUG: Clonidin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lintuzumab-Ac225 in Combination With Cladribine + Cytarabine + Filgastrim + Mitoxantrone (CLAG-M) for Relapsed/Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Lintuzumab-Ac-225 (Dose 1: 0.25 μCi/kg Ac-225 with 1.6 μg/kg lintuzumab)|DRUG: Cladribine|DRUG: Cytarabine|DRUG: Mitoxantrone|DRUG: G-CSF|BIOLOGICAL: Lintuzumab-Ac-225 (Dose 2: 0.50 μCi/kg Ac-225 with 3.2 μg/kg lintuzumab)|BIOLOGICAL: Lintuzumab-Ac-225 (Dose 3: 0.75 μCi/kg with 4.7μg/kg lintuzumab)|BIOLOGICAL: Lintuzumab-Ac-225 (Dose 4: 1.00 μCi/kg with 6.4 μg/kg lintuzumab)|BIOLOGICAL: Lintuzumab-Ac-225 (Dose 5: 1.25 μCi/kg with 8.0 μg/kg lintuzumab)|BIOLOGICAL: Lintuzumab-Ac-225 (Recommended Phase 2 Dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of a Thyme and Honey Spray for Oral Toxicities
Status: UNKNOWN
Conditions: Cancer of the Head and Neck|Xerostomia|Oral Mucositis|Radiation Toxicity
Interventions: DIETARY_SUPPLEMENT: Thyme and Honey-based oral spray|DIETARY_SUPPLEMENT: Placebo oral spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Conditioned Open-label Placebo (COLP) for Peri-operative Pain Management in Patients With Head and Neck Cancer
Status: COMPLETED
Conditions: Postoperative Pain|Opioid Use
Interventions: BEHAVIORAL: Conditioned open-label placebo (COLP)|BEHAVIORAL: Surveys about pain, opioid use and depression symptoms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Maternal Scent and Preterm Infant Nutrition
Status: UNKNOWN
Conditions: Behavior, Infant|Development, Infant|Development, Child
Interventions: OTHER: Maternal scent cloth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Urinary Prostaglandin E Metabolite (PGE-M), A Metabolite of Prostaglandin E2 (PGE2): A Novel Biomarker of Crohn's Disease Activity
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: PROCEDURE: Fecal calprotectin|PROCEDURE: Urinary PGE-M Level
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pilot Studies of Novel Therapies to Treat Resistant Focal Segmental Glomerulosclerosis (FSGS)
Status: COMPLETED
Conditions: Focal Glomerulosclerosis
Interventions: DRUG: Rosiglitazone (Avandia)|DRUG: Adalimumab (Humira)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An RCT of 19G EBUS-TBNA Needle in Suspected Sarcoidosis
Status: COMPLETED
Conditions: Sarcoidosis
Interventions: DEVICE: 19 gauge needle|DEVICE: 22 gauge needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Extended-release, Once Daily Tramadol for Post Operative Analgesia in Shoulder Arthroscopy
Status: TERMINATED
Conditions: Pain|Vertigo|Nausea|Pruritus
Interventions: DRUG: tramadol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Argon Plasma Coagulation for Barrett's Esophagus
Status: COMPLETED
Conditions: Barretts Esophagus With Low Grade Dysplasia
Interventions: DEVICE: Argon Plasma Coagulation 90W power|DEVICE: Argon Plasma Coagulation 60W power|DRUG: Omeprazole 120 mg|DRUG: Omeprazole 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Comparative, Prospective Study of Daily Trimethoprim / Sulfamethoxazole (TMS) and Thrice-Weekly TMS for Prophylaxis Against PCP in HIV-Infected Patients
Status: COMPLETED
Conditions: Pneumonia, Pneumocystis Carinii|HIV Infections
Interventions: DRUG: Sulfamethoxazole-Trimethoprim
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Immunogenicity of GSK Meningococcal Group B Vaccine When Administered Concomitantly With GSK Meningococcal MenACWY Conjugate Vaccine in Healthy Subjects of 16-18 Years of Age
Status: ACTIVE_NOT_RECRUITING
Conditions: Infections, Meningococcal
Interventions: COMBINATION_PRODUCT: Meningococcal Group B Vaccine (GSK3536829A) (rMenB+OMV NZ)|BIOLOGICAL: Meningococcal MenACWY Conjugate Vaccine (GSK3536820A) (MenA lyo + MenCWY liquid)|COMBINATION_PRODUCT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of MT10109L in the Treatment of Glabella Line(Including a Preliminary Study to Evaluate Safety of MT10109L)
Status: COMPLETED
Conditions: Glabella Line Severity
Interventions: DRUG: Botulinum Toxin Type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib, Paclitaxel, and Carboplatin Combined With Radiation Therapy for Stage III Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: Erlotinib|DRUG: paclitaxel|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irinotecan Hydrochloride Liposome Combined With Capecitabine and Lenvatinib in Patients With Biliary Tract Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Biliary Tract Carcinoma
Interventions: DRUG: irinotecan hydrochloride liposome injection|DRUG: Capecitabine|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study for the Treatment of Breast Cancer: the Patient Will Receive Afatinib Plus Letrozole or Letrozole Alone
Status: TERMINATED
Conditions: Breast Neoplasms
Interventions: DRUG: Letrozole|DRUG: Afatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quetiapine for the Reduction of Cocaine Use
Status: COMPLETED
Conditions: Cocaine Dependence|Cocaine Abuse|Cocaine Addiction|Drug Abuse|Substance Abuse
Interventions: DRUG: quetiapine fumarate|DRUG: Matched Placebo|BEHAVIORAL: Cognitive-behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Substance Use Treatment and Recovery Team (START)
Status: COMPLETED
Conditions: Opioid-use Disorder|Opioid-Related Disorders|Alcohol Use Disorder|Alcohol-Related Disorders
Interventions: BEHAVIORAL: Substance Use Treatment and Recovery Team (START)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation of Desmoteplase in Acute Ischemic Stroke (DEDAS)
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: Desmoteplase|DRUG: Desmoteplase|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radiofrquency Ablation Combined With Cytokine-induced Killer Cells for the Patients With Cervical Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Cancer
Interventions: PROCEDURE: Radiofrequency ablation|BIOLOGICAL: Cytokine-induced killer cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Observation of Ningmitai Capsule in Treating Chronic Pelvic Pain Syndrome With Erectile Dysfunction
Status: COMPLETED
Conditions: Chronic Prostatitis With Chronic Pelvic Pain Syndrome|Erectile Dysfunction
Interventions: DRUG: Sildenafil|DRUG: Ningmitai capsule|DRUG: Ningbitai capsule + sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sex Differences in Sympathetic Activity and Vascular Reactivity During Acute and Chronic Hypoxia.
Status: COMPLETED
Conditions: Vasodilation|Vasoconstriction
Interventions: DRUG: Phenylephrine Hydrochloride|OTHER: Cold Pressor Test|OTHER: Isocapnic Acute Hypoxia|OTHER: Hyperoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Extension Trial to Assess the Safety of Re-dosing of Iron Isomaltoside/Ferric Derisomaltose (Monofer®/Monoferric®)
Status: COMPLETED
Conditions: Iron Deficiency Anemia|Iron Deficiency Anaemia
Interventions: DRUG: Iron isomaltoside/ferric derisomaltose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Low Back Pain Graded - Exposure Psychoeducation Intervention
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: BEHAVIORAL: Interactive - Psychoeducation|BEHAVIORAL: Non-interactive Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Cadonilimab and Chemoradiotherapy in Esophageal Cancer (EC-CRT-006)
Status: RECRUITING
Conditions: Esophagus Cancer
Interventions: DRUG: Cadonilimab|DRUG: Paclitaxel and cisplatin|RADIATION: intensity-modulated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OTSC vs. Angiographic Embolization in Patients With Refractory Non-variceal Upper Gastrointestinal Bleeding
Status: RECRUITING
Conditions: Upper Gastrointestinal Bleeding
Interventions: DEVICE: The OTSC® System Set|PROCEDURE: angiographic embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Regulation of Endogenous Glucose Production by Brain Insulin Action
Status: COMPLETED
Conditions: Insulin Resistance, Diabetes
Interventions: DRUG: Intranasal insulin|DRUG: Intranasal placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: CABALA Diet & Health Study
Status: UNKNOWN
Conditions: Healthy
Interventions: OTHER: Apple|OTHER: Oats|DIETARY_SUPPLEMENT: Lactobacillus reuteri NCIMB 30242|OTHER: Cornflakes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SYH2053
Status: NOT_YET_RECRUITING
Conditions: Hyperlipemia
Interventions: DRUG: SYH2053|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of Suprascapular Nerve Block in Adhesive Capsulitis
Status: NOT_YET_RECRUITING
Conditions: Adhesive Capsulitis
Interventions: DRUG: Triamcinolone Acetonide|DRUG: saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II/III Trial of CCRT With or Without JP001 for Newly Diagnosed GBM
Status: RECRUITING
Conditions: Glioblastoma
Interventions: RADIATION: CCRT|DRUG: Temozolomide|DRUG: Siroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: to Assess the Accuracy and Reliability of the Ga68-Dolacga Positron Emission Tomography Compared to Computer Tomography Volumetry and Indocyanine Green Retention Test for Measurement of Liver Reserve
Status: COMPLETED
Conditions: Hepatic Carcinoma
Interventions: DRUG: Ga68-Dolacga Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pilot Study to Evaluate the Impact of Denosumab on Disseminated Tumor Cells (DTC) in Patients With Early Stage Breast Cancer
Status: TERMINATED
Conditions: Early Stage Breast Cancer
Interventions: DRUG: Denosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Anxiety Detection in Pediatrics Using Health Information Technology
Status: COMPLETED
Conditions: Anxiety|Attention Deficit Hyperactivity Disorder|Disorder, Pediatric
Interventions: OTHER: Automated screening for pediatric anxiety|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: A School-Based Intervention to Reduce Stigma & Promote Mental-Health Service Use
Status: COMPLETED
Conditions: Stigma, Social|Mental Illness
Interventions: BEHAVIORAL: Curriculum|BEHAVIORAL: Contact|BEHAVIORAL: Materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: SORT-OUT VI - Randomized Clinical Comparison of Biomatrix Flex® and Resolute Integrity®
Status: COMPLETED
Conditions: Coronary Artery Disease|Angina Pectoris
Interventions: DEVICE: Drug eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: T Cells co- Expressing a Second Generation Glypican 3-specific Chimeric Antigen Receptor With Cytokines Interleukin-21 and 15 as Immunotherapy for Patients With Liver Cancer (TEGAR)
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma|Hepatoblastoma
Interventions: GENETIC: TEGAR T cells|DRUG: Cytoxan|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DV Combined With Cadonilimab in Subjects With HER2-expressing Gastric Cancer and Gastroesophageal Junction Adenocarcinoma After Progression on First-line Therapy
Status: RECRUITING
Conditions: Gastric Cancer|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Disitamab Vedotin Injection|DRUG: Cadonilimab Injection|DRUG: Paclitaxel Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Potassium Supplementation for Adult Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DIETARY_SUPPLEMENT: Potassium supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Efficacy and Safety of REGN3918 in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)
Status: COMPLETED
Conditions: Paroxysmal Nocturnal Hemoglobinuria (PNH)
Interventions: DRUG: REGN3918
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness Using Pegasys and Copegus in Recipients of Liver Transplantation With Hepatitis C
Status: COMPLETED
Conditions: Liver Transplant|Hepatitis C
Interventions: DRUG: Pegasys|DRUG: Copegus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Civamide Nasal Solution for Cluster Headache
Status: NOT_YET_RECRUITING
Conditions: Episodic Cluster Headache
Interventions: DRUG: Civamide nasal solution 0.01%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Self-administered tDCS for Improving Single- and Dual-task Gait in Patients With PD
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remote Pulmonary Function Testing and Nurse Coaching in ALS
Status: COMPLETED
Conditions: ALS
Interventions: DEVICE: remote pulmonary function testing|DEVICE: standard pulmonary function testing|BEHAVIORAL: Nurse Respiratory Health Coaching (NRHC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Initial Dosing of BI 655130 in Palmoplantar Pustulosis Patients
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Spesolimab (low dose)|DRUG: Placebo|DRUG: Spesolimab (high dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimized Management After Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension
Status: UNKNOWN
Conditions: Chronic Thromboembolic Pulmonary Hypertension
Interventions: PROCEDURE: telerehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nab-paclitaxel Plus Gemcitabine as First-line Therapy for Cisplatin-ineligible or Cisplatin-incurable Advanced Urothelial Carcinoma
Status: TERMINATED
Conditions: Urothelial Carcinoma|Bladder Cancer|Transitional Cell Carcinoma
Interventions: DRUG: nab-paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Fractional Bipolar Radiofrequency for the Treatment of Striae
Status: COMPLETED
Conditions: Striae
Interventions: DEVICE: bipolar radiofrequency and infrared|DEVICE: fractional bipolar radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phe for Me? The Effects of L-Phe on PKU Carriers and Non-carriers
Status: NOT_YET_RECRUITING
Conditions: Autosomal Recessive Disorder (Genetic Carriers of PKU)
Interventions: DIETARY_SUPPLEMENT: L-Phenylalanine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: High Intensity Interval Training on Cardiopulmonary Parameters With or Without Facemask in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: High Intensity Interval Training (With Face Mask)|OTHER: High Intensity Interval Training (Without Face Mask)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Remote Ischemic Conditioning on Dynamic Cerebral Autoregulation, Blood Pressure and Heart Rate Variability in Patients With Cerebral Small Vessel Disease
Status: RECRUITING
Conditions: Cerebral Small Vessel Diseases
Interventions: PROCEDURE: Remote ischemic conditioning|PROCEDURE: Sham remote ischemic conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the Fruit-based Product OPAL A for the Treatment of Chronic Venous and Pressure Ulcers
Status: SUSPENDED
Conditions: Venous Ulcer|Pressure Ulcer
Interventions: DRUG: OPAL A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exparel Infiltration in Anterior Cruciate Ligament Reconstruction
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Liposomal bupivacaine|PROCEDURE: Femoral nerve block|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating EKB-569 in Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small-Cell Lung Carcinoma|Carcinoma, Non-Small Cell Lung|Lung Neoplasms
Interventions: DRUG: EKB-569
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dose Ara-C (HDAC) and Interleukin-2 (IL-2) for Patients With Acute Myelogenous Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia
Interventions: DRUG: cytosine arabinoside (ara-C)|DRUG: daunomycin|DRUG: interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Investigate the Influence of Severe Hepatic Impairment on the Pharmacokinetics of Acalabrutinib and Its Metabolite
Status: COMPLETED
Conditions: Hepatic Impairment|Hepatic Insufficiency|Healthy Subjects
Interventions: DRUG: acalabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beetroot Extract Supplementation Associated With an Exercise Protocol for Chronic Kidney Disease Patients
Status: RECRUITING
Conditions: Chronic Kidney Diseases
Interventions: DIETARY_SUPPLEMENT: Beetroot juice|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vitamin D Supplement Study for Stage Three and Four Chronic Kidney Disease (CKD) Patients
Status: TERMINATED
Conditions: Chronic Kidney Disease Stage 3 and 4
Interventions: DRUG: Ergocalciferol|DRUG: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of BIA 2-093 on the Pharmacokinetics of a Combined Oral Contraceptive.
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: BIA 2-093|DRUG: Contraceptives, Oral, Combined
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electroencephalographic Monitoring in Patients Treated by Deep Brain Stimulation
Status: UNKNOWN
Conditions: Motor Disorders|Psychiatric Disorder
Interventions: OTHER: EEG|OTHER: DBS switched OFF and ON
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: BL22 Immunotoxin in Treating Patients Previously Treated With Cladribine for Hairy Cell Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: BL22
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Trial of Verubecestat (MK-8931) in Mild to Moderate Alzheimer's Disease (P07738)
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: Verubecestat (Part I and Part II)|DRUG: Verubecestat (Part I and Part II)|DRUG: Verubecestat (Part I and Part II)|DRUG: Placebo (Part I)|DRUG: Verubecestat (Part II)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Platelets Rich Fibrin and Nanohydroxyapatite in the Treatment of Intrabony Defects
Status: COMPLETED
Conditions: Bony Defects
Interventions: PROCEDURE: OFD alone|DRUG: Platelet rich Fibrin|DRUG: Nanohydroxyapatite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effect of Ketamine and Magnesium Sulfate Gargling With Placebo on Post-operative Sore Throat
Status: COMPLETED
Conditions: Postoperative Complications
Interventions: DRUG: Magnesium sulfate versus ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ibrutinib With or Without Bortezomib and Dexamethasone in Treating Patients With Relapsed or Refractory Immunoglobulin Light Chain Amyloidosis
Status: WITHDRAWN
Conditions: Amyloidosis|Immunoglobulin Light Chain Deposition
Interventions: DRUG: Bortezomib|DRUG: Dexamethasone|DRUG: Ibrutinib|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Doxorubicin and Interleukin-2 in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Liver Cancer
Interventions: BIOLOGICAL: aldesleukin|DRUG: doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: Treatment of Post-Operative Pain Following Orthopedic Surgery With SPRINT® Peripheral Nerve Stimulation (PNS) System
Status: COMPLETED
Conditions: Postoperative Pain|Total Knee Replacement|Total Knee Arthroplasty|Partial Knee Replacement
Interventions: DEVICE: SPRINT Peripheral Nerve Stimulation (PNS) System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Can Medical Personnel Properly Proceed in the Case of a Patient With Bradycardia?
Status: UNKNOWN
Conditions: Bradycardia
Interventions: DEVICE: electrostimulation|DEVICE: cardiopulmonary resuscitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT