pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety/Tolerability Study of Alcohol Injection for Treatment of BPH (Enlarged Prostate)
Status: COMPLETED
Conditions: Prostate Disease|BPH|Benign Prostatic Hyperplasia|Benign Prostatic Hypertrophy
Interventions: DRUG: dehydrated alcohol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: A Product Performance Evaluation of a Novel Contact Lens for Daily Disposable Use
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Novel Bausch & Lomb daily disposable contact lenses|DEVICE: Bausch & Lomb SofLens daily disposable contact lenses.|DEVICE: Johnson and Johnson 1-Day Acuvue Moist contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Functional and Phenotypic Characterization of Monocytes in Myeloproliferative Syndromes
Status: RECRUITING
Conditions: Myeloproliferative Neoplasm|Polycythemia Vera|Essential Thrombocythemia|Primary Myelofibrosis
Interventions: DIAGNOSTIC_TEST: Monocytes signatures in myeloproliferative neoplasms at diagnosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ramucirumab in Treating Patients With Advanced or Metastatic, Previously Treated Biliary Cancers That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Cholangiocarcinoma|Liver and Intrahepatic Bile Duct Carcinoma|Stage III Gallbladder Cancer AJCC v7|Stage III Intrahepatic Cholangiocarcinoma AJCC v7|Stage IIIA Gallbladder Cancer AJCC v7|Stage IIIB Gallbladder Cancer AJCC v7|Stage IV Gallbladder Cancer AJCC v7|Stage IVA Gallbladder Cancer AJCC v7|Stage IVA Intrahepatic Cholangiocarcinoma AJCC v7|Stage IVB Gallbladder Cancer AJCC v7|Stage IVB Intrahepatic Cholangiocarcinoma AJCC v7|Unresectable Gallbladder Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Ramucirumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Colon Neoadjuvant FOLFOXIRI Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Rectal Cancer
Interventions: DRUG: neoadjuvant FOLFOXIRI|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Adenoviral Conjunctivitis With SHP640 Compared to Povidone-iodine (PVP-I) and Placebo
Status: TERMINATED
Conditions: Adenoviral Conjunctivitis
Interventions: DRUG: SHP640|DRUG: PVP-I 0.6%|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability and Pharmacokinetics of SUVN-G3031 in Healthy Subjects
Status: COMPLETED
Conditions: Cognitive Disorders
Interventions: DRUG: SUVN-G3031|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MsFLASH-04: Pilot Trial: Telephone Behavioral Therapy for Menopause-related Sleep Disturbance
Status: COMPLETED
Conditions: Hot Flashes|Menopause|Vasomotor Disturbance|Sleep
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy-Insomnia (CBT-I)|BEHAVIORAL: Menopause Education Control (MEC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Polyphenols and Insulin Resistance
Status: COMPLETED
Conditions: Healthy Volunteers|Insulin Resistance|Type 2 Diabetes (T2D)
Interventions: DRUG: polyphenol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Role of Endobronchial Needle Aspiration With Rapid On-site Evaluation in the Diagnosis of Central Malignant Lesions
Status: COMPLETED
Conditions: Lung Cancer
Interventions: PROCEDURE: EBNA with ROSE|PROCEDURE: standard EBNA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Clinical Study to Investigate if Transfusion of Patients Own Shed Blood Improves the Immunological Status in Comparison to Transfusion of Donor Blood ("Bank Blood")
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee|Blood Transfusion, Autologous|Blood Transfusion
Interventions: DEVICE: Bellovac ABT|PROCEDURE: Allogenic Blood Transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quality Improvement of Person-Centered Care for Maternal Health in Public Facilities in India, Phase 2
Status: COMPLETED
Conditions: Reproductive Health
Interventions: BEHAVIORAL: Person-Centered Care Quality Improvement Collaborative Sustain|BEHAVIORAL: Person-Centered Care Quality Improvement Collaborative Spread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nimotuzumab Combined With Chemoradiotherapy for Unresectable Locally Advanced Squamous Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small-cell Lung Cancer
Interventions: DRUG: Nimotuzumab|DRUG: docetaxel and cisplatin|RADIATION: daily RT to the chest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib/II Study Investigating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With CHOP or CHP-Polatuzumab Vedotin in Participants With B-Cell Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: B-cell Non-Hodgkin Lymphoma
Interventions: DRUG: Mosunetuzumab|DRUG: Polatuzumab Vedotin|DRUG: Rituxumab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-Fluciclovine PET-MRI in High-grade Glioma
Status: RECRUITING
Conditions: Glioma|High Grade Glioma|Glioma, Malignant|Glioma Intracranial|Diffuse Glioma
Interventions: DRUG: 18F-Fluciclovine PET-MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: S0225 Capecitabine in Treating Patients Who Have Undergone Surgery for Locally Recurrent or Persistent Head and Neck Cancer
Status: WITHDRAWN
Conditions: Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity|Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Recurrent Squamous Cell Carcinoma of the Hypopharynx|Recurrent Squamous Cell Carcinoma of the Larynx|Recurrent Squamous Cell Carcinoma of the Oropharynx
Interventions: DRUG: capecitabine|PROCEDURE: adjuvant therapy|PROCEDURE: chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Ciclesonide Nasal Aerosol in Subjects 6-11 Years With Perennial Allergic Rhinitis (PAR).
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis|PAR
Interventions: DRUG: Ciclesonide nasal aerosol 37 mcg|DRUG: ciclesonide nasal aerosol 74 mcg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Diabetes Retinopathy Among Type 2 Diabetic Patients Treated With Different Regimens
Status: RECRUITING
Conditions: Diabetic Retinopathy
Interventions: DRUG: Metformin|DRUG: Lantus|DRUG: Novomix30
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase III Study of ASP2151 in Herpes Zoster Patients
Status: COMPLETED
Conditions: Herpes Zoster
Interventions: DRUG: ASP2151|DRUG: valaciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of BL-B01D1, SI-B003 and BL-B01D1+SI-B003 in Patients With Extensive Stage Small Cell Lung Cancer
Status: RECRUITING
Conditions: Small Cell Lung Cancer
Interventions: DRUG: BL-B01D1|DRUG: SI-B003
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Everolimus Versus Mycophenolate Mofetil in Liver Transplant Recipients.
Status: UNKNOWN
Conditions: Liver Transplant
Interventions: DRUG: Everolimus Tab.|DRUG: Mycophenolate mofetil Tab./Cap.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BM-MNC and UCMSC for Type 2 Diabetes Mellitus Patients
Status: UNKNOWN
Conditions: T2D
Interventions: BIOLOGICAL: Bone-marrow aspiration, Intra-pancreatic Catheterisation of BM-MNC|BIOLOGICAL: Intravenous Infusion of UC-MSC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Hypnosis During Insemination or Embryotransfer
Status: UNKNOWN
Conditions: Reproduction Dysfunction
Interventions: OTHER: clinical hypnosis or relaxation music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Clinical Trial to Investigate the Efficacy and Safety of Evogliptin
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: evogliptin 5mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Psilocybin Therapy for Chronic Low Back Pain
Status: RECRUITING
Conditions: Chronic Low-back Pain
Interventions: DRUG: Psilocybin therapy with Zolpidem and Modafinil|DRUG: Psilocybin therapy with Zolpidem|DRUG: Psilocybin therapy with Modafinil|DRUG: Psilocybin therapy with Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sensation and Skin Pressures Under Blood-Draw Tourniquets
Status: COMPLETED
Conditions: Skin Pressures Under Blood Draw-tourniquets
Interventions: OTHER: Sensation and Skin Surface Pressures Under Blood-Draw Tourniquets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: CD79b CAR-T Cell Therapy for Patients With Relapsed and/or Refractory Acute Lymphoblastic Leukemia and B-cell Non-Hodgkin's Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Relapsed and/or Refractory Acute Lymphoblastic Leukemia|Relapsed and/or Refractory B-cell Non-Hodgkin's Lymphoma
Interventions: DRUG: CD79b CAR-T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Trial of ZD1694 (TOMUDEX), an Inhibitor of Thymidylate Synthase, in Pediatric Patients With Advanced Neoplastic Disease
Status: COMPLETED
Conditions: Neoplasm
Interventions: DRUG: ZD1694 (TOMUDEX)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Methylphenidate in KBG Syndrome: N-of-1 Series
Status: NOT_YET_RECRUITING
Conditions: Kbg Syndrome|ADHD - Combined Type
Interventions: DRUG: Methylphenidate Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Fludarabine With Pegylated Liposomal Doxorubicin Versus Pegylated Liposomal Doxorubicin Alone In Patients With Platinum Resistant/Refractory Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: DRUG: Fludarabine and Pegylated liposomal doxorubicin|DRUG: Pegylated liposomal doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Little ACF (Lilla ABC): Evaluation of a Parental Support Program for Parents of Children Aged 1-2 Years
Status: RECRUITING
Conditions: Parental Support|Emotion Regulation|Coping Behavior|Stress, Emotional|Coparenting
Interventions: BEHAVIORAL: Little ACF [in Swedish: Lilla ABC]|BEHAVIORAL: Lectures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Trastuzumab Biosimilar (Herzuma®) Plus Treatment of Physician's Choice (TPC) in Patients With HER-2 Positive Metastatic Breast Cancer
Status: UNKNOWN
Conditions: HER2-positive Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: Herzuma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arterial Spin Labeling MRI for Assessing Blood Perfusion in the Human Eye Repeatability Study and Clinical Application
Status: RECRUITING
Conditions: Retinal Diseases
Interventions: DIAGNOSTIC_TEST: MRI perfusion imaging using ASL's non-invasive technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Soy Isoflavones in Treating Patients With Recurrent Prostate Cancer or Rising Prostate-Specific Antigen
Status: COMPLETED
Conditions: Recurrent Prostate Cancer|Stage IV Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: Arm I Soy Bread|DIETARY_SUPPLEMENT: Arm II Soy-Almond Bread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: New Imaging Procedure for the Localisation of Insulinoma
Status: COMPLETED
Conditions: Endogenous Hyperinsulinaemic Hypoglycaemia
Interventions: OTHER: Ga -exendin PET/CT, In- exendin SPECT/CT, MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Assistive Device on ADL Function in Patients With Nerve Injury
Status: COMPLETED
Conditions: Nerve Injury
Interventions: BEHAVIORAL: Wear 3D printing assistive device|BEHAVIORAL: Wear universal cuff device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: T-mult: Exploring the Impact of TMS Induced Virtual Lesions on the Multimodal Brain Network and Cognition
Status: RECRUITING
Conditions: Healthy Cognition
Interventions: DEVICE: repetitive transcranial magnetic stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Pilot Study to Evaluate the Use of OroScience Topical Oral Wound Emulsion in Post Operative Wound Healing
Status: COMPLETED
Conditions: Oral Surgical Procedures|Pain
Interventions: DEVICE: OroScience Topical Oral Wound Emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Muscle Relaxation for Short Procedures
Status: COMPLETED
Conditions: Intubating Conditions|Fasciculations|Postoperative Myalgia|Patient Satisfaction|Sore Throat
Interventions: DRUG: Succinylcholine|DRUG: Rocuronium/Sugammadex|DRUG: Rocuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Minimum Concentration of Tranexamic Acid Required to Inhibit Fibrinolysis in a Population of Pregnant Women at Term.
Status: COMPLETED
Conditions: Hyperfibrinolysis
Interventions: PROCEDURE: Blood sampling (pregnant)|PROCEDURE: Blood sampling (non pregnant)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Dalcetrapib in Patients With Stable Coronary Heart Disease, With Coronary Heart Disease Risk Equivalents or at Elevated Risk for Cardiovascular Disease
Status: COMPLETED
Conditions: Cardiovascular Disease, Coronary Heart Disease, Dyslipidemia, Peripheral Arterial Disease (PAD)
Interventions: OTHER: Background care|DRUG: Placebo|DRUG: dalcetrapib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Senofilcon A Contact Lenses Using a Novel Manufacturing Technology
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: ACUVUE® OASYS 1-DAY|DEVICE: ACUVUE® OASYS 1-DAY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Negative Pressure Vs. Compression in Venous Ulcers
Status: COMPLETED
Conditions: Varicose Ulcer
Interventions: DEVICE: Bridged V.A.C.® with compression therapy|DEVICE: Conventional Compression Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preservative-free Topical Anesthetics for Post-PRK Pain
Status: COMPLETED
Conditions: Myopia
Interventions: DRUG: Preservative-free Benoxinate hydrochloride 0.4% (Benoxidia unit-dose vials [UD], Orchidia pharmaceutical Ind., Egypt)|DRUG: Preservative-free Sodium hyaluronate 0.2% (Polyfresh unit-dose vials [UD], Orchidia pharmaceutical Ind., Egypt).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhanced Care for Patients With Complex Multimorbidity in Primary Care
Status: NOT_YET_RECRUITING
Conditions: Multimorbidity
Interventions: OTHER: Complex intervention to enhance care for patients with multimorbidity in general practice consisting of an extended overview consultation and supporting elements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A First-in-human Study of GENA-104A16 in Patients With Advanced Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: GENA-104A16
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Carcinoma|Metastatic Colon Adenocarcinoma|Metastatic Rectal Adenocarcinoma|Stage III Colon Cancer AJCC v8|Stage III Rectal Cancer AJCC v8|Stage IIIA Colon Cancer AJCC v8|Stage IIIA Rectal Cancer AJCC v8|Stage IIIB Colon Cancer AJCC v8|Stage IIIB Rectal Cancer AJCC v8|Stage IIIC Colon Cancer AJCC v8|Stage IIIC Rectal Cancer AJCC v8|Stage IV Colon Cancer AJCC v8|Stage IV Rectal Cancer AJCC v8|Stage IVA Colon Cancer AJCC v8|Stage IVA Rectal Cancer AJCC v8|Stage IVB Colon Cancer AJCC v8|Stage IVB Rectal Cancer AJCC v8|Stage IVC Colon Cancer AJCC v8|Stage IVC Rectal Cancer AJCC v8|Unresectable Colon Adenocarcinoma|Unresectable Rectal Adenocarcinoma
Interventions: DRUG: Savolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic Meniscus Surgery
Status: COMPLETED
Conditions: Meniscus Tear, Tibial|Pain, Postoperative|Postoperative Complications|Ketorolac Adverse Reaction|Opioid Use
Interventions: DRUG: Ketorolac|DRUG: Oxycodone-Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel and Cyclophosphamide Compared to Anthracycline-Based Chemotherapy in Treating Women With HER2-Negative Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Docetaxel|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of SG001 in Combination With Nab-Paclitaxel in Patients With Advanced Triple-Negative Breast Cancer (TNBC)
Status: UNKNOWN
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: SG001|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relmacabtagene Autoleucel as Second-Line Therapy in Adult Patients With Aggressive B-cell NHL
Status: NOT_YET_RECRUITING
Conditions: Lymphoma, Large B-Cell, Diffuse|Follicular Lymphoma Grade 3B|High-grade B-cell Lymphoma|Mediastinal B-Cell Diffuse Large Cell Lymphoma
Interventions: BIOLOGICAL: Relmacabtagene Autoleucel|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Treatments for Fungal Infections of the Mouth and Throat in HIV-Infected Patients Who Have Had Success With Itraconazole But Not With Fluconazole
Status: COMPLETED
Conditions: Candidiasis, Oral|HIV Infections
Interventions: DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Safety, Tolerability, Pharmacokinetics of PF-06305591 in Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06305591|DRUG: Placebo|DRUG: PF-06305591|DRUG: Placebo|DRUG: PF-06305591|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multidimensional Rehabilitation Programs for Cognitive Impairment in Comorbid Outpatients: a Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Cognitive Impairment|Dementia|Comorbidities and Coexisting Conditions|Vascular Dementia|Dementia, Mixed
Interventions: OTHER: Motor rehabilitation alone|OTHER: Motor rehabilitation and Cognitive rehabilitation (paper-based)|OTHER: Motor rehabilitation and cognitive rehabilitation (digital-based)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Transcutaneous Nerve Stimulation on Primary Motor Cortex to Modulate Cortical Excitability and Hemodynamic Response During Implicit Motor Learning: A TMS and NIRS Study
Status: UNKNOWN
Conditions: Transcutaneous Nerve Stimulation
Interventions: DEVICE: "Enraf-Nonius" Muscle stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Bronchodilators on the Exercise Capacity of Bronchiectasis Patients
Status: ENROLLING_BY_INVITATION
Conditions: Bronchiectasis Adult
Interventions: DRUG: Bronchodilator (Ipratropium and Fenoterol)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Concordance Between Sonography Amd MRI for Presurgical Diagnosis of Uterine Mesenchymal Malignant Tumors
Status: TERMINATED
Conditions: Leiomyoma|Leiomyosarcoma
Interventions: PROCEDURE: Pre-surgical diagnosis of uterine malignant tumors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Meditation and Biofeedback to Improve Anxiety, Depression and Quality of Life in Inpatients After Stroke
Status: RECRUITING
Conditions: Stroke
Interventions: BEHAVIORAL: Technology Supported Meditation and Biofeedback|OTHER: Standard Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of the Benefit of a Nurse (IDE) Pre and Post-operative Framework in Proctology Outpatient Surgery
Status: WITHDRAWN
Conditions: Proctology|Surgery
Interventions: PROCEDURE: Enhanced support|PROCEDURE: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Tarloxotinib in Pts With NSCLC (EGFR Exon 20 Insertion, HER2-activating Mutations) & Other Solid Tumors With NRG1/ERBB Gene Fusions
Status: TERMINATED
Conditions: NSCLC, Stage IV|NSCLC Stage IIIB|NSCLC, Stage IIIC|NSCLC, Recurrent|EGFR Exon 20 Insertion Mutation|HER2-activating Mutation|ERBB Fusion|NRG1 Fusion
Interventions: DRUG: tarloxotinib bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accuracy of Two Methods of Making Impressions for Complete-arch Implant Supported Fixed Prosthesis
Status: NOT_YET_RECRUITING
Conditions: Edentulous Jaw
Interventions: DEVICE: intraoral scan|DEVICE: open tray impression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Blood Flow Restriction-based Abdominal draw-in Maneuver on Activation of Abdominal Core Muscles in Patients With Non-specific Low Back Pain
Status: RECRUITING
Conditions: Non-specific Low Back Pain
Interventions: DEVICE: blood flow restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Mediclore as an Anti-adhesion Agent and Safety in Full-endoscopic Spine Surgery: a Preliminary Study
Status: NOT_YET_RECRUITING
Conditions: Lumbar Disc Disease|Epidural Fibrosis|Failed Back Surgery Syndrome
Interventions: DRUG: Mediclore|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Intravesical PPM Therapy for NMIBC
Status: RECRUITING
Conditions: Non-muscle-invasive Bladder Cancer
Interventions: DRUG: PLZ4-coated paclitaxel-loaded micelles (PPM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Pilot Study of the Efficacy of Polymyxin-B Hemoperfusion in Critically Ill Patients With Severe Sepsis
Status: COMPLETED
Conditions: Severe Sepsis
Interventions: PROCEDURE: Polymyxin-B Hemoperfusion|PROCEDURE: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: One Year Clinical Evaluation of White Spot Lesions Treated With Newly Introduced Resin Modified Glass Ionomer in Comparison to Resin Infiltration in Anterior Teeth Split Mouth Technique
Status: UNKNOWN
Conditions: White Spot Lesions
Interventions: DRUG: Vanish xt Extended Contact Varnish|DRUG: resin infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Learn if the Combination of Fianlimab, Cemiplimab, and Chemotherapy is Safe and Works Better Than the Combination of Cemiplimab and Chemotherapy in Adult Patients With Non-Small Cell Lung Cancer That Can be Treated With Surgery
Status: RECRUITING
Conditions: Resectable Non-small Cell Lung Cancer
Interventions: DRUG: Fianlimab|DRUG: Cemiplimab|DRUG: Pemetrexed|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coronary CT Angiography in Non ST-elevation Myocardial Infarction
Status: RECRUITING
Conditions: Non-ST Elevated Myocardial Infarction
Interventions: PROCEDURE: Coronary CT angiography|PROCEDURE: Invasive coronary angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dose-escalation Study of Oral Administration of S 055746 in Patients With Acute Myeloid Leukaemia or Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Acute Myeloid Leukaemia (AML)|Myelodysplastic Syndrome (MDS)
Interventions: DRUG: S 055746
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes Of Mega-dosage Supplementations Of Cholecalciferol In Critically Ill Patients With Sepsis
Status: NOT_YET_RECRUITING
Conditions: Critically Ill|Sepsis|Mortality Rate|Critical Care
Interventions: OTHER: Placebo|OTHER: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Controlled, Double-masked, Investigator-initiated Trial to Evaluate Tear Film Quality and Stability in Subjects With Dry Eye Disease Using OC-01 (Varenicline Solution) Nasal Spray 0.03 mg as Compared to Vehicle Control Nasal Spray
Status: UNKNOWN
Conditions: Dry Eye Disease
Interventions: DRUG: Varenicline solution|DRUG: Placebo nasal spray (OC-01 Vehicle Nasal Spray)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1a/b Dose Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of OMP-131R10
Status: COMPLETED
Conditions: Advanced Relapsed Tumors|Refractory Solid Tumors
Interventions: DRUG: OMP-131R10|DRUG: FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Farber Disease Natural History Study
Status: COMPLETED
Conditions: Farber Disease|Farber's Disease|Farber Lipogranulomatosis|Acid Ceramidase Deficiency|Ceramidase Deficiency|N-Laurylsphingosine Deacylase Deficiency|ASAH1 Mutation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vascular Function Improvements After Chronic Passive Stretching
Status: COMPLETED
Conditions: Vasodilation|Vasoconstriction|Stretch|Sympathetic; Imbalance
Interventions: OTHER: Passive stretching (PS) training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a pd vWF/FVIII, Biostate®, in Subjects With Haemophilia A
Status: COMPLETED
Conditions: Hemophilia A
Interventions: BIOLOGICAL: Biostate® [SP]|BIOLOGICAL: Biostate® [SP]|BIOLOGICAL: Biostate® [RP]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Open-Label Treatment Protocol to Observe the Safety of Replagal (Agalsidase Alfa) Enzyme Replacement Therapy in Canadian Patients With Fabry Disease
Status: COMPLETED
Conditions: Fabry Disease
Interventions: BIOLOGICAL: agalsidase alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Intravenous IDOV-SAFETM in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Neoplasms
Interventions: BIOLOGICAL: Oncolytic Virus injection(IDOV-SAFETM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT of Carvedilol Versus Variceal Band Ligation in the Primary Prophylaxis of Oesophageal Variceal Haemorrhage
Status: UNKNOWN
Conditions: Portal Hypertension
Interventions: DRUG: Carvedilol|PROCEDURE: Esophageal variceal band ligation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Multicenter Prospective Randomized Control Study on Persona Total Knee System vs NexGen
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Persona total knee system|DEVICE: Nexgen total knee system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Fentanyl for Pain Control During First-Trimester Uterine Aspiration
Status: COMPLETED
Conditions: Pain Uterus
Interventions: DRUG: Fentanyl|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effects of Exercise on Patients With Chiari Malformation
Status: COMPLETED
Conditions: Chiari Malformation Type I|Proprioceptive Disorders|Coordination and Balance Disturbances|Syringomyelia|Basilar Invagination|Exercise Addiction|Atlanto-Axial Subluxation
Interventions: BEHAVIORAL: Motor learning based exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Specific Enteral Nutrition in Malnourished, Dialysis Patients With Chronic Kidney Disease. Efficacy, Safety, Quality of Life
Status: WITHDRAWN
Conditions: Chronic Kidney Disease|Renal Failure Chronic Requiring Hemodialysis|Severe Malnutrition|Tolerance|Quality of Life|Activity|Appetite and General Nutritional Disorders
Interventions: DIETARY_SUPPLEMENT: RealDiet®Renal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Body Weight Adjusted Clopidogrel Treatment in Patients With CORonary Artery Disease
Status: RECRUITING
Conditions: Coronary Artery Disease|Platelet Reactivity
Interventions: DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Non-Myeloablative Haplo-identical Haematopoietic Stem Cell Transplantation in Patients With Haematological Malignancies or Acquired Aplastic Anaemia
Status: UNKNOWN
Conditions: Haematological Malignancies|Acquired Aplastic Anaemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ultra-brief Online Mindfulness-based Intervention During COVID-19 Movement Control Order
Status: COMPLETED
Conditions: Mental Health Wellness|Psychological Security|Psychological Distress
Interventions: BEHAVIORAL: Ultra Brief Online Mindfulness-based Intervention|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Joint Thoracic Oncology Research Unit of LYon: Lung cancerS DatabaSE (ULYSSE)
Status: RECRUITING
Conditions: Lung Cancer
Interventions: OTHER: Quality of life questionnaire|BIOLOGICAL: Blood sample|OTHER: Quality of life questionnaire|OTHER: Quality of life questionnaire|OTHER: Quality of life questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Drug-Drug Interaction Study Between EDP-938, Tacrolimus, Dabigatran, Rosuvastatin and Midazolam in Healthy Subjects
Status: COMPLETED
Conditions: RSV Infection
Interventions: DRUG: EDP-938|DRUG: EDP-938|DRUG: EDP-938|DRUG: Tacrolimus|DRUG: Dabigatran|DRUG: Rosuvastatin|DRUG: EDP-938|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Endometrial Cancer|Kidney Cancer|Ovarian Cancer|Pheochromocytoma|Sarcoma
Interventions: BIOLOGICAL: filgrastim|DRUG: doxorubicin hydrochloride|DRUG: ifosfamide|DRUG: isolated perfusion|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Phase III Randomized Study of Anti-Tumor Necrosis Factor Chimeric Monoclonal Antibody (cA2) for Patients With Enterocutaneous Fistulae as a Complication of Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: monoclonal antibody cA2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Early Discharge in Patients Undergoing Elbow Arthroscopy
Status: COMPLETED
Conditions: Elbow Arthroscopy Surgery
Interventions: PROCEDURE: Elbow arthroscopy with infraclavicular nerve block and continuous local anesthetic infusion to day 3 post op.|OTHER: Early Discharge|OTHER: Normal Discharge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Safety and Tolerability Study of Andes-1537 for Injection in Patients With Advanced Unresectable Solid Tumors
Status: TERMINATED
Conditions: Advanced Unresectable Solid Tumors
Interventions: DRUG: Andes-1537 for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study Comparing Tiotropium Easyhaler and Spiriva Handihaler
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Tiotropium Bromide Monohydrate|DRUG: Tiotropium Bromide Monohydrate|DRUG: Tiotropium Bromide Monohydrate|DRUG: Tiotropium Bromide Monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of RIV4 Versus IIV4 in Pregnant Women
Status: COMPLETED
Conditions: Safety|Adverse Event Following Immunisation|Birth Outcomes
Interventions: BIOLOGICAL: Quadrivalent Recombinant Influenza Vaccine|BIOLOGICAL: Quadrivalent Inactivated Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Pain Relief Post Knee Arthroscopy Using IPACK + Adductor Canal Block Vs. Adductor Canal Block Alone
Status: RECRUITING
Conditions: Postoperative Pain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Exogenous Melatonin in Intensive Care Unit Chronodisruption
Status: RECRUITING
Conditions: Sleep Deprivation|Intensive Care Psychosis
Interventions: DRUG: Melatonin 5 mg|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Functional Evaluation After Breast Reconstruction With a Minimally Invasive Latissimus Dorsi Flap Following Radical Surgery for Breast Cancer.
Status: RECRUITING
Conditions: Breast Cancer
Interventions: PROCEDURE: Surgery for unilateral breast reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adult (18-40 Years Old)
Status: COMPLETED
Conditions: Typhoid Fever
Interventions: BIOLOGICAL: Typherix|BIOLOGICAL: NVGH Vi-CRM197
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Gamma Light and Sound Stimulation to Prevent Dementia in Cognitively Normal People at Risk for Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease|Family Members
Interventions: DEVICE: GENUS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multisensory Body and Space Representations (BASES-EXTINCTION)
Status: UNKNOWN
Conditions: Healthy|Blindness
Interventions: OTHER: Electrooculogram (EOG)|OTHER: Surface Electromyography (EMG)|OTHER: Electrodermal response|OTHER: Changes in skin temperature|OTHER: MRI|OTHER: MEG|OTHER: Transcranial magnetic stimulation (TMS)|OTHER: Transcranial electrical stimulation in direct current (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Aromatherapy for Chemotherapy-induced Symptoms
Status: TERMINATED
Conditions: Chemotherapy Symptoms
Interventions: DRUG: Ginger|DRUG: Lavender|DRUG: Orange|DRUG: Jojoba
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Use of TIPSS in Patients With Cirrhosis and Variceal Bleeding
Status: COMPLETED
Conditions: Liver Cirrhosis|Variceal Haemorrhage
Interventions: PROCEDURE: Endoscopic Variceal Band Ligation|PROCEDURE: Transjugular Intrahepatic Porto-Systemic Stent Shunt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Impact of a Coenzyme Q10 Supplementation on the Skin
Status: COMPLETED
Conditions: Wrinkles|Ageing|Photoprotection
Interventions: DIETARY_SUPPLEMENT: Placebo group|DIETARY_SUPPLEMENT: Quvital LD group|DIETARY_SUPPLEMENT: Quvital HD group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Comparison Study Between Ketamine Versus Tramadol for Pain Management After Major Upper Abdominal Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Tramadol|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of NGR-hTNF in Combination With Doxorubicin in Patients Affected by Soft Tissue Sarcomas.
Status: COMPLETED
Conditions: Metastatic Adult Soft Tissue Sarcoma
Interventions: DRUG: low-dose NGR-hTNF|DRUG: high-dose NGR-hTNF|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Letermovir for the Prevention of Cytomegalovirus Reactivation in Patients With Hematological Malignancies Treated With Alemtuzumab
Status: ACTIVE_NOT_RECRUITING
Conditions: B-Cell Prolymphocytic Leukemia|Chronic Lymphocytic Leukemia|Peripheral T-Cell Lymphoma|Primary Cutaneous T-Cell Non-Hodgkin Lymphoma|Sezary Syndrome|T-Cell Prolymphocytic Leukemia
Interventions: DRUG: Letermovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Amniotic Versus Synthetic Membrane as a Transient Skin Cover for Pediatric Burns
Status: UNKNOWN
Conditions: Burns
Interventions: BIOLOGICAL: Amniotic Membrane Dressing|DEVICE: Synthetic Dressing|PROCEDURE: Standard Wound Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy and Safety of Yoni.Fit in Women With Stress Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: DEVICE: Yōni.Fit Test Device|DEVICE: Yōni.Fit Comparator Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Modulation of GABA-A Receptors in Parkinson Disease-Flumazenil Arm
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Flumazenil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Treatment Response Adapted Hybrid Radiotherapy in Metastatic Non-small Cell Lung Cancer Receiving First-line Immunotherapy
Status: RECRUITING
Conditions: NSCLC Stage IV
Interventions: RADIATION: SBRT or LDRT|DRUG: PD-1/PD-L1 inhibitor combined with platinum-based chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melatonin for Delirium Prophylaxis
Status: WITHDRAWN
Conditions: Delirium
Interventions: DRUG: Melatonin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Investigate the Relationship Between Exercise Training and Recovery Ratio to Improve Physical Performance and Health Status
Status: RECRUITING
Conditions: Exercise|Recovery
Interventions: BEHAVIORAL: A regular training volume|BEHAVIORAL: A lower exercise volume group|BEHAVIORAL: A longer rest group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of DBT Compared to Drug Counseling for Opiate Addicts
Status: COMPLETED
Conditions: Opiate Addiction|Borderline Personality Disorder
Interventions: BEHAVIORAL: Dialectical Behavior Therapy|BEHAVIORAL: Drug Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bortezomib, Paclitaxel, and Carboplatin in Treating Patients With Unresectable, Metastatic Cancer of the Esophagus or Gastroesophageal Junction
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: bortezomib|DRUG: carboplatin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT