pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Evaluate the Effect of a Single Oral Dose of ZX-7101A on the QTc Interval in Healthy Subjects
Status: NOT_YET_RECRUITING
Conditions: Influenza, Human
Interventions: DRUG: ZX-7101A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Discharge Coordinator Intervention in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Coordinated discharge|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Ultrasound Bone Strength Device to Measure Calcaneal Bone Strength Index of Human Subjects
Status: COMPLETED
Conditions: Clinical Trial|Comparative Effectiveness Research|Equipment Safety
Interventions: DEVICE: Oste-scan 500A|DEVICE: SONOST3000
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Prazosin for Post-Concussive Headaches
Status: COMPLETED
Conditions: Post-Traumatic Headache
Interventions: DRUG: Prazosin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Colon Cancer Screening Tests
Status: TERMINATED
Conditions: Colorectal Cancer|Colon Cancer|Adenomatous Polyps
Interventions: OTHER: Fecal occult blood test|PROCEDURE: Virtual colonoscopy|PROCEDURE: Optical colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Parnaparin vs Aspirin in the Treatment of Retinal Vein Occlusion
Status: TERMINATED
Conditions: Retinal Vein Occlusion
Interventions: DRUG: parnaparin|DRUG: aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sustained Release Lidocaine for the Treatment of Postoperative Pain
Status: RECRUITING
Conditions: Postoperative Pain|Postsurgical Pain
Interventions: DRUG: ST-01|DRUG: Control (Lidocaine Hydrochloride Injection USP Xylocaine® or Bupivacaine Hydrochloride Injection USP Marcaine®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Topical Calcipotriol-assisted AFL-PDT in Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Dermatosis
Interventions: DRUG: Topical Vitamin D (Calcipotriol) application|DRUG: Placebo cream application|DRUG: lidocaine/prilocaine (5%) application|DEVICE: 2940-nm Er:YAG AFL pretreatment|DRUG: MAL application|OTHER: Measurements of the fluorescence intensity|DEVICE: irradiation with red light-emitting diode lamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindful Parenting - A Single Case Experimental Design Study
Status: RECRUITING
Conditions: Parenting|Alopecia|Skin Condition|Limb Difference|Neurofibromatoses|Craniofacial|Cleft Lip and Palate
Interventions: BEHAVIORAL: Mindful Parenting Programme
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-Operative Or Peri-Operative Dox Regimen In Patients With Locally Advanced Resectable Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer|Locally Advanced Malignant Neoplasm
Interventions: OTHER: DOX 4 cycles - Surgery|OTHER: DOX 2 cycles - Surgery - DOX 2 cycles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of Tacrolimus Capsules, 5 mg of Dr. Reddys's Laboratories Limited Under Non-Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tacrolimus Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Coronary Calcium Score as a Marker of Post-radiation Vascular Dysplasia in Adults Treated During Childhood for Cancer With Mediastinal Irradiation
Status: RECRUITING
Conditions: Childhood Cancer
Interventions: OTHER: Coronal calcium score measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination Therapy to Treat Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DRUG: Placebo pill|DRUG: Sedative|OTHER: Room air|OTHER: Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety,Tolerability and Immunogenicity of Vaccination With VARIVAX in Healthy Indian Children (V210-056)
Status: COMPLETED
Conditions: Varicella
Interventions: BIOLOGICAL: Varicella Virus Vaccine Live (Oka-Merck)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Melatonin Effect in Combination With Neoadjuvant Chemotherapy to Clinical Response in Locally Advanced Oral Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Oral Squamous Cell Carcinoma|Neoadjuvant Chemotherapy
Interventions: DRUG: Melatonin 20 MG Oral Capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Goji vs. Fiber on Macular Degeneration
Status: RECRUITING
Conditions: Age-Related Macular Degeneration
Interventions: DIETARY_SUPPLEMENT: Goji berry|DIETARY_SUPPLEMENT: Fiber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Lung Injury From COVID-19 Infection With Intravenous Sodium Nitrite
Status: WITHDRAWN
Conditions: COVID-19|Acute Respiratory Distress Syndrome|Acute Respiratory Failure
Interventions: DRUG: Sodium Nitrite|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AZD8075 Study to Assess the Safety, Tolerability and Pharmacokinetics of Multiple Ascending Oral Doses of AZD8075 in Healthy Male Volunteers
Status: WITHDRAWN
Conditions: Healthy
Interventions: DRUG: AZD8075|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Panitumumab, Chemotherapy, and External-Beam Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer That Cannot be Removed by Surgery
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: panitumumab|DRUG: capecitabine|DRUG: fluorouracil|DRUG: gemcitabine hydrochloride|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Slowing HEART diSease With Lifestyle and Omega-3 Fatty Acids
Status: COMPLETED
Conditions: Coronary Heart Disease|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Omega 3 acid ethyl esters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Target Volumes in NPC Treated With Induction Chemotherapy Followed by Concurrent Chemoradiotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Nasopharyngeal Carcinoma|Induction Chemotherapy|Radiotherapy
Interventions: RADIATION: Delineating the GTV according to the pretreatment or post-IC tumor extension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Molecular Imaging of Prostate-Specific Membrane Antigen Using Labeled Technetium-99m BQ0413
Status: ENROLLING_BY_INVITATION
Conditions: Prostate Cancer
Interventions: DRUG: Whole body study and SPECT with [99mTc]Tc-BQ0413
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Assess the Immunogenicity, Tolerability and Safety of a Malaria Vaccine and Also Its Protective Efficacy in a Malaria Challenge Model
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: Ad35.CS.01/Ad26.CS.01 low dose (1 x 10^10 vp)|BIOLOGICAL: Ad 35.CS.01/Ad 26.CS.01 high dose (5 x 10^10 vp)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of MK-1942 as an Adjunct Therapy in Participants With Mild to Moderate Alzheimer's Disease Dementia (MK-1942-008)
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: MK-1942|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Abatacept vs Placebo in RA Patients With Hepatitis B on Entecavir Background
Status: WITHDRAWN
Conditions: Rheumatoid Arthritis|Chronic Hepatitis B
Interventions: DRUG: Abatacept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Breathing and Core Stability Exercise Effects on Lumbopelvic Pain
Status: UNKNOWN
Conditions: Breathing Sound|Low Back Pain|Post-operative Pain|Pelvic Pain
Interventions: OTHER: traditional physical therapy|OTHER: core stability exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Web-Based Physical Activity Intervention in Adolescent Survivors of Childhood Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: BEHAVIORAL: Activity Monitor|BEHAVIORAL: Interactive Website|BEHAVIORAL: Educational Materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Avelox for Treatment of Elderly Patients With Community Acquired Pneumonia
Status: COMPLETED
Conditions: Pneumonia
Interventions: DRUG: Avelox (Moxifloxacin, BAY12-8039)|DRUG: Levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Belantamab Mafodotin in Combination With Kd for the Treatment of Relapsed Myeloma Patients, Refractory to Lenalidomide
Status: RECRUITING
Conditions: Relapsed Multiple Myeloma
Interventions: DRUG: Belantamab mafodotin|DRUG: Carfilzomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Cohort Study of DHA in Neurodevelopmental Disorders
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism or Autistic Traits
Interventions: DIETARY_SUPPLEMENT: Docosahexaenoic acid supplement|DIETARY_SUPPLEMENT: ASD placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combined Lumbosacral Nerve Block Versus Spinal Anesthesia for Cognitive Function After Hip Prothesis
Status: UNKNOWN
Conditions: Cognitive Decline
Interventions: OTHER: unilateral lumbosacral nerve block|OTHER: Spinal anesthesia|OTHER: Placebo at the spinal anesthesia level|OTHER: Placebo at lumbosacral level
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Non Operative Treatment for Acute Appendicitis
Status: COMPLETED
Conditions: Lower Abdominal Pain|Right Iliac Fossa Pain|Acute Appendicitis
Interventions: DRUG: Amoxicillin and Clavulanic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of a Dual-agent Local Analgesic (Bupivacaine-meloxicam) for Abdominal Incisions in Patients Undergoing Retropubic Mid-urethral Sling Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Stress Urinary Incontinence|Surgical Incision|Pain Vulva
Interventions: DRUG: Bupivacaine-Meloxicam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Health Related Lifestyle and Quality of Life in Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Quality of Life|Physical Activity|Physical Disability|Parenting|Sleep Disorder
Interventions: OTHER: interventional study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effectiveness of Brushing and Flossing Sequence on Control of Plaque and Gingival Inflammation
Status: COMPLETED
Conditions: Gingival Inflammation|Plaque|Gingival Bleeding|Plaque Control
Interventions: OTHER: Brushing first and Flossing later (BF)|OTHER: Flossing first and Brushing later (FB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The NADage Study: Nicotinamide Riboside Replenishment Therapy Against Functional Decline in Aging
Status: NOT_YET_RECRUITING
Conditions: Frailty|Frail Elderly Syndrome|Frailty Syndrome|Aging
Interventions: DIETARY_SUPPLEMENT: Nicotinamide Riboside (NR)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy and Safety of Sunitinib in Renal Cell Carcinoma Progressed to 1L Immunotherapy Treatment.
Status: COMPLETED
Conditions: Clear Cell Renal Carcinoma
Interventions: DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of a Regular Borjomi® Consumption on an Anaerobic Performance
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Regular consumption of natural mineral water Borjomi® with high bicarbonate content|OTHER: Regular consumption of processed drinking water Smart Spring®|OTHER: Regular consumption of still drinking water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Aromasin (Exemestane) in Patients With Recurrent or Refractory Stage II - IV Epithelial Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer
Status: COMPLETED
Conditions: Leukemia|Lymphoma|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases
Interventions: DRUG: busulfan|DRUG: cyclophosphamide|DRUG: cytarabine|RADIATION: radiation therapy|DRUG: Etoposide|PROCEDURE: Stem Cell Transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Selective Intra-Arterial Cooling Infusion Combined With EVT in Acute Ischemic Stroke
Status: RECRUITING
Conditions: Acute Ischemic Stroke|Hypothermia
Interventions: PROCEDURE: Selective Intra-arterial Cooling Infusion (IA-SCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of an Anti-HER3 Antibody, HMBD-001, With Docetaxel +/- Cetuximab in Advanced Squamous Non-small Cell Lung Cancers
Status: RECRUITING
Conditions: Advanced or Metastatic Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: HMBD-001|DRUG: Docetaxel|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study for Patients With Complicated Skin and Skin Structure Infections
Status: COMPLETED
Conditions: Staphylococcal Skin Infections|Wounds and Injuries|Abscess|Cellulitis|Streptococcal Infections
Interventions: DRUG: oritavancin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of FreeO2 (Version 4) in All Patients Receiving Oxygen
Status: COMPLETED
Conditions: Respiratory Disease|Respiratory Failure|COPD Exacerbation|Asthma|Pneumonia
Interventions: DEVICE: FreeO2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: PredictEndTB Signature for Individualizing Treatment in Multidrug-Resistant Tuberculosis
Status: TERMINATED
Conditions: Tuberculosis, Pulmonary|Tuberculosis, Multidrug-Resistant|Bacterial Infections|Mycobacterial Infection
Interventions: DIAGNOSTIC_TEST: Individualised treatment duration based on RNA transcriptomic model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of External Nasal Nerve Block in Prevention of Postoperative Agitation Following Nasal Surgeries
Status: COMPLETED
Conditions: Agitation States as Acute Reaction to Gross Stress
Interventions: PROCEDURE: External nasal nerve block|DRUG: saline adrenaline|DRUG: Xylocaine, adrenaline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Folate Receptor Alpha Peptide Vaccine With GM-CSF in Patients With Triple Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: Low dose FRα vaccine|DRUG: Cyclophosphamide|BIOLOGICAL: High dose FRα vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inflammatory Cytokines Profile in Individuals Subjected to Surgical Procedures Using Propofol or Isoflurane
Status: COMPLETED
Conditions: Patients in Good Health
Interventions: DRUG: Propofol and isoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Testing the Addition of an Immunotherapy Drug, Tremelimumab, to the PARP Inhibition Drug, Olaparib, for Recurrent Ovarian, Fallopian Tube or Peritoneal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Fallopian Tube Endometrioid Tumor|Fallopian Tube High Grade Serous Adenocarcinoma|Malignant Ovarian Endometrioid Tumor|Ovarian High Grade Serous Adenocarcinoma|Platinum-Sensitive Fallopian Tube Carcinoma|Platinum-Sensitive Ovarian Carcinoma|Platinum-Sensitive Primary Peritoneal Carcinoma|Primary Peritoneal High Grade Serous Adenocarcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Fallopian Tube Endometrioid Adenocarcinoma|Recurrent Ovarian Endometrioid Adenocarcinoma|Recurrent Ovarian Serous Adenocarcinoma|Recurrent Primary Peritoneal Carcinoma|Recurrent Primary Peritoneal Endometrioid Adenocarcinoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Olaparib|BIOLOGICAL: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Urate-Lowering Activity and Safety of Oral BCX4208 Administered in Subjects With Gout
Status: COMPLETED
Conditions: Gout
Interventions: DRUG: placebo|DRUG: BCX4208
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sputum Labeling Utilizing Synthetic Meso Tetra (4-Carboxyphenyl) Porphine (TCPP) for Detection of Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DEVICE: CyPath
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of MVA85A in Healthy Infants
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: MVA85A/AERAS-485|BIOLOGICAL: Candida Skin Test Antigen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sanctura Muscarinic Receptor Antagonist Resists Transport (SMART-II) Trial
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: trospium chloride|DRUG: oxybutynin IR|DRUG: oxybutynin IR placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Intravenous Immunoglobulin (IVIG) Post-Portoenterostomy in Infants With Biliary Atresia
Status: COMPLETED
Conditions: Biliary Atresia
Interventions: DRUG: Intravenous immunoglobulin (IVIG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b/2 Study of AMG 655 in Combination With Paclitaxel and Carboplatin for the First-Line Treatment of Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: AMG 655|OTHER: AMG 655 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemotherapy Versus Radiochemotherapy for Cancer of the Esophagus or Cardia
Status: COMPLETED
Conditions: Carcinoma, Squamous Cell|Adenocarcinoma of the Esophagus and Gastric Cardia
Interventions: DRUG: Chemotherapy|RADIATION: Radiochemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Standard Intensive Chemotherapy Versus Intensive Chemotherapy With CPX-351 in Adult Patients With Newly Diagnosed AML and Intermediate- or Adverse Genetics
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Cytarabine|DRUG: Daunorubicin|DRUG: CPX-351
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperthermia European Adjuvant Trial
Status: UNKNOWN
Conditions: Resected Pancreatic Adenocarcinoma
Interventions: DEVICE: Gemcitabine + Cisplatin + regional hyperthermia|DRUG: Gemcitabine + Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of LH-8 in Paediatric Alopecia Areata
Status: COMPLETED
Conditions: Alopecia Areata|Pediatric Disorder
Interventions: DRUG: LH-8|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation (tDCS) for Depression in Pregnancy: A Pilot Study
Status: COMPLETED
Conditions: Depression|Pregnancy
Interventions: DEVICE: Active tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of SCFA Supplementation in Subjects Receiving Abdominopelvic RT: A Randomized Controlled Study
Status: RECRUITING
Conditions: Toxicity|Radiation Toxicity
Interventions: DRUG: Short Chain Fatty Acid|DRUG: Tapioca Flour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Trial of Micafungin (FK463) in Combination With Liposomal Amphotericin B (AmBisome) for Aspergillosis
Status: TERMINATED
Conditions: Aspergillosis
Interventions: DRUG: Micafungin|DRUG: Liposomal Amphotericin B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Pharmacokinetics, and Antiviral Activity of ABI-5366 in Healthy Participants and Participants Seropositive for HSV-2 With Recurrent Genital Herpes
Status: RECRUITING
Conditions: Recurrent Genital Herpes Simplex Type 2
Interventions: DRUG: ABI-5366|DRUG: ABI-5366 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Research on Key Technologies for Risk Prediction and Precise Diagnosis and Treatment of AIS Based on Epigene-phenotype
Status: NOT_YET_RECRUITING
Conditions: Adolescent Idiopathic Scoliosis
Interventions: BEHAVIORAL: Low risk experimental group|BEHAVIORAL: Medium risk experimental group|GENETIC: High risk experimental group|BEHAVIORAL: Control group COBB 10-20°|BEHAVIORAL: Control group COBB 20-45°|BEHAVIORAL: Control group COBB >45°|OTHER: Experimental group (AIS group)|OTHER: Control group (healthy control)|OTHER: Controlled follow-up before and after AIS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Maximal Use Trial Evaluating the Pharmacokinetic Profile of MC2-01 Cream
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: MC2-01 Cream|DRUG: CAL/BDP combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of a Simplified Severity Score (Investigator Global Assessment: IGA) in Bullous Pemphigoid
Status: NOT_YET_RECRUITING
Conditions: Bullous Pemphigoid
Interventions: OTHER: IGA score|OTHER: BULLOUS PEMPHIGOID DISEASE AREA INDEX (BPDAI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Extension Trial of Deforolimus (Ridaforolimus, MK-8669) in Participants With Advanced Cancer (MK-8669-038)
Status: TERMINATED
Conditions: Advanced Cancers
Interventions: DRUG: Ridaforolimus Tablet|DRUG: Ridaforolimus Intravenous (IV) Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carboplatin Taxol Avastin in Ovarian Cancer (OVCA)
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Carboplatin/Paclitaxel/Cetuximab in Stage IIIB/IV Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: Cetuximab|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of the Tolvaptan Tablets in Patients With Non-hypovolemic Non-acute Hyponatremia
Status: UNKNOWN
Conditions: Non-hypovolemic Non-acute Hyponatremia
Interventions: DRUG: Tolvaptan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Association of T Gamma Delta-CD16+ Cells and Anti-CMV Immunoglobulins in the Prevention of CMV Infection
Status: RECRUITING
Conditions: Kidney Transplantation|CMV Infection
Interventions: DRUG: Cytotect
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: De-implementing Low Value Preoperative Care Wisely
Status: NOT_YET_RECRUITING
Conditions: Surgery-Complications|Anesthesia Complication
Interventions: BEHAVIORAL: De-implementation Bundle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combination of Cryosurgey and NK Immunotherapy for Recurrent Pharyngeal Cancer
Status: COMPLETED
Conditions: Recurrent Pharyngeal Cancer
Interventions: DEVICE: Cryosurgery|BIOLOGICAL: NK immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Community Intervention in the Chronic Use of Benzodiazepines: (BENZOSTOPJUNTOS)
Status: COMPLETED
Conditions: Inappropriate Prescribing
Interventions: BEHAVIORAL: Intervention for reducing benzodiazepines long-term use.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Nano+ Polymer-free Sirolimus-Eluting Stent: A Optical Coherent Tomography Study
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: Nano+ DES
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robotic-Assisted or Laparoscopic Radical Resection for Rectal Cancer With or Without Left Colic Artery Preservation
Status: COMPLETED
Conditions: Rectal Cancer|Left Colic Artery Stenosis (Diagnosis)|Robotic Assisted Laparoscopic Surgery
Interventions: PROCEDURE: with or without Left Colic Artery Preservation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Kuopio Ischaemic Heart Disease Risk Factor Study (Nutrition Component)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases|Diabetes|Metabolic Syndrome|Cancer|Inflammatory Disease|Atherosclerosis|Cognitive Decline|Liver Diseases|Death|Pain, Chronic|Depression|Infection|Chronic Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Determine the Effect of Multiple Oral Doses of SLx-2119 in Healthy Male Subjects
Status: COMPLETED
Conditions: Immune System Disorder (Healthy Volunteer)
Interventions: DRUG: Belumosudil mesylate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Erector Spinae Plane Block and Combination of Deep and Superficial Serratus Anterior Plane Block
Status: COMPLETED
Conditions: Pain, Postoperative|Thoracic Surgery, Video-Assisted|Erector Spinae Plane Block|Serratus Anterior Plane Block|Multimodal Analgesia
Interventions: PROCEDURE: Erector Spinae Plane Block|PROCEDURE: Deep and Superficial Serratus Anterior Plane Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Dose Omega-3 Fatty Acids in the Treatment of Sport Related Concussions
Status: COMPLETED
Conditions: Mild Concussion|Brain Concussion|Cerebral Concussion
Interventions: DIETARY_SUPPLEMENT: Docosahexaenoic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Avenir Müller Hip Stem Post Market Surveillance Study
Status: COMPLETED
Conditions: Osteoarthritis, Hip|Rheumatoid Arthritis|Fracture of Hip|Dislocated Hip|Osteonecrosis|Post-traumatic; Arthrosis|Subluxation Hip
Interventions: DEVICE: Patients who met the inclusion/exclusion criteria to receive the Avenir Müller stem.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open-label Study in Patients With Metastatic NSLC Treated With Cisplatin, Gemcitabine and Bevacizumab
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: gemcitabine, cisplatin and bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Durvalumab Plus "Booster" RT for Metastatic Adenocarcinoma Pancreas Cancer Post Chemotherapy (GCC 1598)
Status: WITHDRAWN
Conditions: Metastatic Pancreas Cancer
Interventions: DRUG: Durvalumab|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Vitamin D in HIV Progression, Birth Outcomes, and Child Health
Status: COMPLETED
Conditions: HIV
Interventions: DIETARY_SUPPLEMENT: Vitamin D3 (cholecalciferol)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Use of Wharton Jelly Derived Mesenchymal Stem Cells for Knee Osteoarthrosis
Status: UNKNOWN
Conditions: Knee Osteoarthrosis
Interventions: BIOLOGICAL: Wharton Jelly derived mesenchymal stem cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study A)
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: ARV-471|DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Relative Bioavailability of E7386 Following Oral Administration of Targeted Release (TR) Tablets Compared to an E7386 Immediate Release (IR) Tablet in Healthy Adult Participants
Status: WITHDRAWN
Conditions: Healthy Volunteers
Interventions: DRUG: E7386
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Improving Physical, Mental, and Spiritual Health in Faith-Based Settings Through Creating a Healthy Culture in Bronx, NY
Status: COMPLETED
Conditions: Mental Health Issue
Interventions: BEHAVIORAL: The Seven Pathways to Healing, Health and Wellness curriculum
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Using Optical Coherence Tomography (OCT) to Evaluate the Efficacy and Safety of PEGylated Interferon Beta-1a (BIIB017) in Patients With Relapsing Multiple Sclerosis
Status: WITHDRAWN
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: BIIB017
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Two-stage ORIF Vs Ex. Fix. in Complex Pilon Fractures
Status: COMPLETED
Conditions: Pilon Fracture
Interventions: PROCEDURE: Two-stage Open reduction and internal fixation ( ORIF) using plates & screws|PROCEDURE: single-stage external fixation (EX.FIX.) with minimal internal fixation using cannulated screws if needed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Vitamin D in Colorectal Cancer Chemoprevention
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Vitamin D3 (cholecalciferol)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: 64Cu-DOTATATE PET-CT-skanning and Infective Endocarditis.
Status: RECRUITING
Conditions: Endocarditis|Endocarditis;Chronic|Endocarditis Acute
Interventions: RADIATION: 64Cu-DOTATATE and 18F-FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Affective Disorders: Eliminate WArning Signs And REstore Functioning: AWARE
Status: COMPLETED
Conditions: Mood Disorders|Activities of Daily Living|Quality of Life
Interventions: COMBINATION_PRODUCT: AWARE intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First-in-human Phase I to Evaluate PEP-010 as Single Agent and in Combination With Paclitaxel or With Gemcitabine (CleverPeptide)
Status: RECRUITING
Conditions: Metastatic Solid Tumor Cancer
Interventions: COMBINATION_PRODUCT: Dose escalation, first-in-human phase I clinical trial with an Expansion phase
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anlotinib Plus Docetaxel for the Treatment of EGFR/ALK/ROS1 Mutation-negative Advanced Nonsquamous NSCLC
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Anlotinib Plus Docetaxel|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Factors Influencing Occurrence of Bile Leaks in Surgery
Status: COMPLETED
Conditions: Bile Leak|Anastomotic Leak Biliary|Biliary Tract Fistula
Interventions: OTHER: bilioenteric anastomosis i
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery
Status: COMPLETED
Conditions: Esophageal Cancer|Nutrition Disorders|Appetite Disorders|Dumping Syndrome|Delayed Gastric Emptying|Surgery
Interventions: DRUG: Octreotide Acetate|DRUG: Saline Solution|DRUG: Paracetamol|DRUG: Sulfasalazine|DIAGNOSTIC_TEST: Duodenal biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open-label Study of Nelotanserin in Lewy Body Dementia With Visual Hallucinations or REM Sleep Behavior Disorder
Status: TERMINATED
Conditions: Lewy Body Dementia|Dementia With Lewy Bodies|Parkinson's Disease Dementia|Visual Hallucinations|REM Sleep Behavior Disorder
Interventions: DRUG: Nelotanserin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effect of Compensatory Cognitive Intervention Among People With Severe Mental Illness
Status: UNKNOWN
Conditions: Mood Disorders|Schizophrenia|Schizoaffective Disorder
Interventions: BEHAVIORAL: compensatory cognitive treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, PK and PD of DISC-0974 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: DISC-0974|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of Pharmacokinetics, Safety and Tolerability After Single Dose Administration of BILR 355 (SDS) Plus Low-dose Ritonavir in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BILR 355 - D1|DRUG: BILR 355 - D2|DRUG: BILR 355 - D3|DRUG: BILR 355 - D4|DRUG: Ritonavir|OTHER: high fat breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Screening for Barrett's Esophagus in Otolaryngology Patients
Status: COMPLETED
Conditions: Extraesophageal Symptoms|Cough|Throat Clearing|Hoarseness|Difficulty Swallowing
Interventions: DIAGNOSTIC_TEST: Screening for Barrett's Esophagus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: QoL in mCRC Elderly Patients Receiving First-line Therapy Based on Simplified Geriatric Parameters.
Status: ACTIVE_NOT_RECRUITING
Conditions: Elderly Patients|Metastatic Colorectal Cancer|Quality of Life
Interventions: DRUG: OPTIMOX-bevacizumab|DRUG: Capecitabine plus bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of the Safety and Efficacy of DFD-03 for the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: DFD-03|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Eltrombopag With Immunosuppressive Therapy in East-Asian Patients With Severe Aplastic Anemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Severe Aplastic Anemia (SAA)
Interventions: DRUG: eltrombopag|DRUG: rabbit anti-thymocyte globulin (r-ATG)|DRUG: cyclosporine A (CsA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apatinib Mesylate Combined With Doxorubicin and Ifosfamide in Advanced Soft-tissue Sarcoma
Status: UNKNOWN
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: Apatinib Mesylate, doxorubicin, ifosfamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Oncoxin Plus Viusid in the Treatment of Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DIETARY_SUPPLEMENT: Oncoxin + Viusid|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient-centered Care Transitions in Heart Failure: A Pragmatic Cluster Randomized Trial
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: PACT-HF Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Stannsoporfin With Light Therapy for Newborn Babies With Jaundice
Status: COMPLETED
Conditions: Jaundice, Neonatal|Hyperbilirubinemia, Neonatal
Interventions: PROCEDURE: Phototherapy|DRUG: Stannsoporfin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Crossover Study of CNV1014802 in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy
Status: COMPLETED
Conditions: Lumbosacral Radiculopathy
Interventions: DRUG: CNV1014802|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Effectiveness of Trastuzumab Emtansine (T-DM1) as Therapy in Chinese Participants With HER2 Positive Advanced Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab emtansine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Control of Colic in Infants by Dietary Supplementation With the Probiotic Lactobacillus Reuteri
Status: UNKNOWN
Conditions: Colic
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of ISIS 325568 in Healthy Volunteers
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: ISIS 325568
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Paclitaxel in Hormone Receptor-positive, hyperMUTATted Metastatic Breast Cancer Identified by Whole exOme sequeNcing ('MUTATION2')
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Pembrolizumab 200mg +Paclitaxel 80mg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Ischemic Postconditioning During Percutaneous Coronary Interventions
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: remote ischemic postconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Associations Between Chemotherapy-Induced Nausea in Patients With Genitourinary, Sarcoma or Melanoma Cancers and Changes in Gut Microbiome: Potential for Precision Therapeutics
Status: RECRUITING
Conditions: Bladder Cancer|Prostate Cancer|Testicular Cancer|Bladder Carcinoma|Genitourinary System Carcinoma|Malignant Testicular Neoplasm|Melanoma|Prostate Carcinoma|Sarcoma
Interventions: OTHER: Blood and Tissue
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dry Needling and Kinesio Taping in the Treatment of Myofascial Pain Syndrome
Status: COMPLETED
Conditions: Myofascial Pain Syndrome of Neck
Interventions: OTHER: Kinesio Taping|OTHER: Dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT