pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy of Lactobacillus Reuteri Protectis on Functional Abdominal Pain (FAP) in Children 8-14 Years Old
Status: TERMINATED
Conditions: Abdominal Pain
Interventions: DIETARY_SUPPLEMENT: L. reuteri protectis|DIETARY_SUPPLEMENT: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Real-world Comparison of FNB and FNA in IHC-required Lesions.
Status: COMPLETED
Conditions: Neuroendocrine Tumors|Autoimmune Pancreatitis|Gastrointestinal Stromal Tumors
Interventions: DEVICE: FNB group|DEVICE: FNA group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Best Treatment in Terms of Quality of Life for Patients Having a Brain Metastasis
Status: UNKNOWN
Conditions: Quality of Life|Brain Metastases
Interventions: PROCEDURE: surgery and focal radiosurgery of the surgical bed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Combination of Buffered Anesthetic to Treat Mandibular Molars
Status: RECRUITING
Conditions: Symptomatic Irreversible Pulpitis
Interventions: DRUG: Sodium bicarbonate|DRUG: Lidocaine w/ epi|DRUG: Articaine w/ epi|DRUG: Mepivacaine plain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Golimumab in Ulcerative Colitis (UC) Patients With Loss of Response (LOR) Followed by Dose Optimization
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Golimumab (Optimization)|DIAGNOSTIC_TEST: Rectosigmoidoscopy|BIOLOGICAL: Blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cold Water Immersion and Atherosclerosis, Inflammation, Fat Accumulation and Lipid Profile Parameters
Status: SUSPENDED
Conditions: Cardiovascular Risk Factor|Metabolic Complication|Endocrine; Complications|Immune System Diseases
Interventions: OTHER: Cold water immersion|OTHER: No cold water immersion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Contrast Ultrasound Perfusion Imaging in PAD With Sonazoid
Status: UNKNOWN
Conditions: Peripheral Artery Disease
Interventions: DRUG: Contrast ultrasound of leg muscle with Sonazoid (Contrast ultrasound microvascular perfusion imaging)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Repetitive Brake Activation
Status: COMPLETED
Conditions: Eating|Obesity|Ileal Brake
Interventions: OTHER: Ileal infusion of casein|OTHER: Ileal infusion of tap water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective Study of Apatinib Plus Concurrent Neoadjuvant Chemoradiotherapy for Siewert II ，III of Locally Advanced HER-2 Negative Adenocarcinoma at Gastroesophageal Junction
Status: UNKNOWN
Conditions: Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: apatinib|DRUG: Capecitabine|DRUG: Oxaliplatin|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Mass Balance of [14C] ABBV-903 in Healthy Male Participants Following Single Oral Dose Administration
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: ABBV-903
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Double-Blind Study to Evaluate the Efficacy and Safety of BMN 110 in Patients With Mucopolysaccharidosis IVA (Morquio A Syndrome)
Status: COMPLETED
Conditions: MPS IV A
Interventions: DRUG: BMN 110 Weekly|DRUG: Placebo|DRUG: BMN 110 Every Other Week
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Experiential Learning on Vegetable Intake in Preschool Children
Status: COMPLETED
Conditions: Food Habits|Food Preferences|Health Behavior|Diet Habit|Child Behavior
Interventions: BEHAVIORAL: Narrative|BEHAVIORAL: Experiential
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: In Vivo Persistence of Adoptively-Transferred TIL Cultured With Akti in People With Metastatic Melanoma
Status: WITHDRAWN
Conditions: Metastatic Melanoma
Interventions: BIOLOGICAL: AKTi-treated TIL|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Dark vs. White Chocolate on the Postprandial Increase in Portal Pressure in Cirrhosis
Status: COMPLETED
Conditions: Cirrhosis|Portal Hypertension
Interventions: DIETARY_SUPPLEMENT: DarkChocolate|DIETARY_SUPPLEMENT: WhiteChocolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of an Anti-inflammatory Diet With or Without Curcumin Supplementation on Anthropometric Measurements, Concentrations of Thyroid Hormones, Anti-TPO, and Systemic Inflammation in Plasma and NFK-B in Peripheral Blood Mononuclear Cells in Patients With Hashimato
Status: NOT_YET_RECRUITING
Conditions: Thyroid Diseases|Hypothyroidism|Hashimoto Disease
Interventions: DIETARY_SUPPLEMENT: curcumin|BEHAVIORAL: Anti-inflammatory diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Eyetracking and Neurovision Rehabilitation of Oculomotor Dysfunction in Mild Traumatic Brain Injury
Status: COMPLETED
Conditions: Mild Traumatic Brain Injury|Brain Concussion|Convergence Insufficiency|Accommodative Insufficiency|Saccadic Eye Movement Deficiency|Oculomotor Dysfunction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adapting a Betel Quid Cessation Program for a High-risk Community in Malaysia and Evaluating Its Effectiveness
Status: NOT_YET_RECRUITING
Conditions: Betel Nut Chewer|Tobacco Cessation
Interventions: BEHAVIORAL: Betel Quid Educational Booklet|BEHAVIORAL: Betel Quid Cessation Intervention Module
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Retrolaminar Block as Opioid Free Anesthesia After Posterior Lumber Spine Discectomy
Status: COMPLETED
Conditions: Opioid Free Anesthesia
Interventions: PROCEDURE: Standard analgesia (paracetamol +fentanyl)|PROCEDURE: Retrolaminar block with bupivacaine + magnesium sulfate + dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Intrathecal Normal Saline for Prevention of Post Dural Puncture Headache in Women Undergoing Cesarean Section Under Spinal Anesthesia
Status: COMPLETED
Conditions: PDPH
Interventions: DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intramyocardial Injection of Autologous Aldehyde Dehydrogenase-Bright Stem Cells for Therapeutic Angiogenesis (FOCUS Br)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: BIOLOGICAL: Stem Cell Therapy|OTHER: Control (plasma)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effect of Osteopathic Manipulative Medicine (OMM) Versus Counseling in the Treatment of Concussion
Status: COMPLETED
Conditions: Post-Concussion Symptoms|Distorted; Balance
Interventions: PROCEDURE: Osteopathic Manipulative Treatment|OTHER: Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Emergency Diabetes Care for Older African Americans
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: BEHAVIORAL: PREVENT|BEHAVIORAL: EUC (Enhanced Usual Care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Erlotinib and Radiation Therapy With or Without Cisplatin in Treating Patients With Mouth or Throat Cancer
Status: COMPLETED
Conditions: Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage II Squamous Cell Carcinoma of the Oropharynx|Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage III Squamous Cell Carcinoma of the Oropharynx|Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IV Squamous Cell Carcinoma of the Oropharynx
Interventions: DRUG: erlotinib hydrochloride|DRUG: cisplatin|RADIATION: intensity-modulated radiation therapy|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recollection Training in Healthy Older Adults and Older Adults With Amnestic Mild Cognitive Impairment
Status: COMPLETED
Conditions: Amnestic Mild Cognitive Impairment|Aging
Interventions: BEHAVIORAL: Recollection Training|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hybrid Persistent Atrial Fibrillation Ablation in Heart Failure
Status: WITHDRAWN
Conditions: Atrial Fibrillation|Heart Failure
Interventions: PROCEDURE: Convergent ablation|PROCEDURE: Catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab, Cisplatin, and Pemetrexed Disodium or Gemcitabine Hydrochloride in Treating Patients With Stage I-IIIA Non-small Cell Lung Cancer That Can Be Removed by Surgery
Status: COMPLETED
Conditions: Non-Squamous Non-Small Cell Lung Carcinoma|Stage I Non-Small Cell Lung Cancer|Stage IA Non-Small Cell Lung Carcinoma|Stage IB Non-Small Cell Lung Carcinoma|Stage II Non-Small Cell Lung Cancer|Stage IIA Non-Small Cell Lung Carcinoma|Stage IIB Non-Small Cell Lung Carcinoma|Stage IIIA Non-Small Cell Lung Cancer
Interventions: BIOLOGICAL: Nivolumab|DRUG: Cisplatin|DRUG: Pemetrexed Disodium|DRUG: Gemcitabine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Gather Information About Rivaroxaban in Patients in the United Kingdom Who Have Cancer and Thrombosis (OSCAR-UK)
Status: COMPLETED
Conditions: Treatment of Venous Thromboembolism in Cancer Patients
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)|DRUG: other DOACs|DRUG: LMWH
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 0/1 Local Application of the Monoclonal Antibody (Mab) sB24M in Patients With Purulent Pyoderma
Status: COMPLETED
Conditions: Pyoderma|Pyoderma Gangrenosum|Pyoderma Vegetans|Pyoderma Gangrenosum Surrounding Surgical Stoma
Interventions: BIOLOGICAL: Monoclonal antibody (Mab) sB24M
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weight Control Programs in Women Who Have Undergone Surgery for Early Stage Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Weight Changes
Interventions: BEHAVIORAL: behavioral dietary intervention|BEHAVIORAL: exercise intervention|OTHER: counseling intervention|OTHER: educational intervention|OTHER: laboratory biomarker analysis|OTHER: questionnaire administration|PROCEDURE: quality-of-life assessment|PROCEDURE: support group therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of a Synbiotic Containing Fructo-oligosaccharides and Bifidobacteria in Middle-aged Adults
Status: COMPLETED
Conditions: Constipation
Interventions: DIETARY_SUPPLEMENT: Synbiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Efficacy and Safety of Kolofort in Functional Dyspepsia Patients
Status: COMPLETED
Conditions: Dyspepsia
Interventions: DRUG: Kolofort|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-Based Eating in Patients With Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Abdominal Pain|Irritable Bowel Syndrome|IBS
Interventions: DIETARY_SUPPLEMENT: Dietary intervention|BEHAVIORAL: Irritable Bowel Syndrome eating awareness training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BIIB014 Effects on the Pharmacokinetics (PK) of Rosiglitazone, Warfarin, and Midazolam
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIIB014|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of Maprotiline in Combination With Tamoxifen and Temozolomide for Recurrent Glioblastoma
Status: WITHDRAWN
Conditions: Glioblastoma|Brain Tumor
Interventions: DRUG: Temozolomide, Tamoxifen, Maprotiline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Evaluation of HORIZANT in Adolescents With Moderate-to-Severe Primary RLS
Status: UNKNOWN
Conditions: RLS
Interventions: DRUG: HORIZANT 300 mg|DRUG: HORIZANT 600 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose Study of WAL0921 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: WAL0921|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pilot Randomized Controlled Trial of Intravenous N-acetyl Cysteine in STEMI
Status: COMPLETED
Conditions: STEMI
Interventions: DRUG: Intravenous N-Acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Defining the Optimal Cryoballoon Duration Therapy for Treatment of Atrial Fibrillation: Defining the Optimal Cryoballoon Duration Therapy for Treatment of Atrial Fibrillation: The 1-2-3 Study
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: OTHER: Cryoballoon ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Recovery Characteristics Between Remimazolam Anesthesia With Flumazenil and Desflurane Anesthesia for Closed Reduction of Nasal Bone Fracture
Status: RECRUITING
Conditions: Anesthesia
Interventions: DRUG: Remimazolam|DRUG: Desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Stereotactic Ablation for Oligometastatic Breast Neoplasia in Combination With the Anti-PD-1 Antibody MK-3475
Status: COMPLETED
Conditions: Breast Neoplasms|Bone Neoplasms
Interventions: RADIATION: Stereotactic Ablative Body Radiosurgery (SABR)|DRUG: MK-3475
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Vortioxetine on Cognitive Dysfunction in Working Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Vortioxetine 10 mg|DRUG: Paroxetine 20 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Induction Chemotherapy Sequential Sintilimab Combined With Dual Epigenetic Drugs for ENKTL-HLH
Status: UNKNOWN
Conditions: Safety and Efficacy
Interventions: DRUG: Sintilimab|DRUG: Chidamide|DRUG: Azacitidine|DRUG: L-DEP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxyapatite-toothpaste and Enamel Caries in the Primary Dentition
Status: COMPLETED
Conditions: Tooth Decay|Hydroxyapatite|Tooth Demineralization|Tooth Diseases
Interventions: PROCEDURE: Prophylactic|PROCEDURE: Cleaning teeth|DEVICE: Restorative dentistry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase III, Open-label, First-line Study of Dato-DXd in Combination With Durvalumab and Carboplatin for Advanced NSCLC Without Actionable Genomic Alterations
Status: RECRUITING
Conditions: NSCLC
Interventions: DRUG: Datopotamab deruxtecan|DRUG: Durvalumab|DRUG: Carboplatin|DRUG: Pembrolizumab|DRUG: Cisplatin|DRUG: Pemetrexed|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EU: A Multicenter Compassionate Use Program of Daclatasvir (BMS-790052) in Combination With Sofosbuvir With or Without Ribavirin for the Treatment of Subjects With Chronic Hepatitis C
Status: NO_LONGER_AVAILABLE
Conditions: Chronic Hepatitis C
Interventions: DRUG: Daclatasvir|DRUG: Sofosbuvir|DRUG: Ribavirin
Study Type: EXPANDED_ACCESS
Clinical trial: Effect of Auricular Vagus Stimulating in Non Specific Chronic Neck Pain
Status: COMPLETED
Conditions: Neck Pain|Vagus|Autonomic Nervous System
Interventions: OTHER: Vagus stimulation|OTHER: Consevative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Abatacept With Methotrexate- Phase IIB
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Abatacept (BMS-188667)|DRUG: Abatacept (BMS-188667)|DRUG: Abatacept (BMS-188667)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nano-curcumin Supplementation in Acute Pancreatitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Pancreatitis
Interventions: DIETARY_SUPPLEMENT: Nano-curcumin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Acute Effects of Myofascial Trigger Point Release in Women With Chronic Pelvic Pain
Status: COMPLETED
Conditions: Pelvic Pain|Pelvic Floor; Relaxation|Myofascial Trigger Point Pain
Interventions: OTHER: Internal myofascial release|OTHER: External myofascial release|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prevalence and Factors Associated With Pancreatic Enzyme Elevations Among Diabetic Children
Status: UNKNOWN
Conditions: Diabetic Children
Interventions: DIAGNOSTIC_TEST: blood glucose, blood gases, serum electrolytes, HbA1c, complete blood count and serum creatinine. Serum calcium, serum amylase, serum lipase and serum triglycerides , abdominal ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ascorbic Acid Levels in MDS, AML, and CMML Patients
Status: COMPLETED
Conditions: Myelodysplastic Syndromes|Acute Myeloid Leukemia|Chronic Myelomonocytic Leukemia|MDS|AML|CMML
Interventions: OTHER: Peripheral blood collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cilostazol Dexborneol Versus Placebo for Microcirculation Dysfunction After Reperfusion Therapy in Patients With Acute Ischemic Stroke With Large Vessel Occlusion
Status: RECRUITING
Conditions: Acute Ischemic Stroke|Reperfusion|Large Vessel Occlusion
Interventions: DRUG: Y-6 sublingual tablets|DRUG: Placebo tablets of Y-6 sublingual tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Amifostine in Treating Patients With Ovarian Epithelial Cancer Who Are Receiving Chemotherapy
Status: COMPLETED
Conditions: Ovarian Cancer|Quality of Life
Interventions: DRUG: amifostine trihydrate|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison Between Arthroscopic Debridement and Repair for Partial-thickness Rotator Cuff Tears
Status: COMPLETED
Conditions: Rotator Cuff Tears
Interventions: PROCEDURE: arthroscopic debridement|PROCEDURE: arthroscopic repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vasopressin Versus Catecholamines for Cerebral Perfusion Pressure Control in Brain Injured Trauma Patients
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: DRUG: arginine vasopressin|DRUG: Standard catecholamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accuracy of Sentinel Lymph Node Biopsy in Nodal Staging of High Risk Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Cancer|Sentinel Lymph Node|Indocyanine Green
Interventions: BIOLOGICAL: Indocyanine Green (ICG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: PV-Isolation With the Cryoballoon Versus RF:a Randomized Controlled Prospective Non-inferiority Trial (FreezeAF)
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: PV-Isolation RF|PROCEDURE: PV-Isolation Cryo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of a Novel Implantable Device for the Treatment of Erectile Dysfunction
Status: RECRUITING
Conditions: Erectile Dysfunction Following Radical Prostatectomy
Interventions: DEVICE: Activation of pro-erectile nerves within the pelvic plexus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PReclude Infection EVEnts With No Prophylaxis Transperineal Biopsy
Status: COMPLETED
Conditions: Infection
Interventions: PROCEDURE: Transperineal MRI-guided prostate biopsy|PROCEDURE: Transrectal MRI-guided prostate biopsy|DRUG: Antibiotic (prophylaxis)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Does Caffeine Affect the Sensitivity of Adenosine Perfusion Scans?
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Cardiac SPECT imaging Rest and Stress|DRUG: Caffeine|DRUG: Caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Liposomal Bupivacaine Nerve Block (Exparel) in Rotator Cuff Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Rotator Cuff Tears|Postoperative Pain|Opioid Use
Interventions: DRUG: Exparel Injectable Solution|DRUG: Bupivacaine Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of BM-MSCs on Early Graft Function Recovery After DCD Kidney Transplant.
Status: UNKNOWN
Conditions: Kidney Transplantation|Acute Kidney Tubular Necrosis
Interventions: OTHER: BM-MSCs|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Exploratory fMRI Study on the Treatment for Impulsive Aggression in Children With Attention-Deficit/Hyperactivity Disorder
Status: TERMINATED
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)|Impulsive Aggression
Interventions: DIAGNOSTIC_TEST: Functional Magnetic Resonance Imaging (fMRI)|DIAGNOSTIC_TEST: Magnetic Resonance Spectroscopy (MRS)|BEHAVIORAL: Point Subtraction Aggression Paradigm (PSAP) Task|DRUG: SPN-810|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Alpha-Defensin and Synovial Proteins to Improve Detection of Pediatric Septic Arthritis
Status: RECRUITING
Conditions: Joint Infection|Infection of Hip Joint (Disorder)|Infection of Shoulder Joint|Septic Arthritis
Interventions: DIAGNOSTIC_TEST: Synovial Alpha-defensin assay|DIAGNOSTIC_TEST: Synovial Neutrophil elastase assay|DIAGNOSTIC_TEST: Synovial lactate assay|DIAGNOSTIC_TEST: Synovial C-reactive Protein (CRP)|DIAGNOSTIC_TEST: Synovial Staphylococcus spp antigen panel|DIAGNOSTIC_TEST: Synovial Candida spp antigen panel|DIAGNOSTIC_TEST: Synovial Enterococcus faecalis assay|DIAGNOSTIC_TEST: Synovial bacterial culture by BacT/Alert|DIAGNOSTIC_TEST: Synovial Cell count + differential (CBC)|DIAGNOSTIC_TEST: Synovial Gram Stain|DIAGNOSTIC_TEST: Synovial Leukocyte Esterase Test Strips|DIAGNOSTIC_TEST: Synovial PCR for Kingella kingae|DIAGNOSTIC_TEST: Serum Cell count + differential (CBC)|DIAGNOSTIC_TEST: Serum erythrocyte sedimentation rate (ESR)|DIAGNOSTIC_TEST: Serum C-reactive Protein (CRP)|DIAGNOSTIC_TEST: Serum D-dimer|DIAGNOSTIC_TEST: Serum Procalcitonin|DIAGNOSTIC_TEST: Blood Cultures|DIAGNOSTIC_TEST: Optional blood testing per standard of care (ASO, anti-strep, ANA, anti-DS-DNA, HLA-B27, RF, Lyme and other inflammatory/ rheumatologic markers )
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: TSN2898-201 Safety and Efficacy of TSN2898 in the Treatment of Acne Vulgaris
Status: WITHDRAWN
Conditions: Acne Vulgaris
Interventions: DRUG: Vehicle|DRUG: TSN2898|DRUG: TSN2898|DRUG: TSN2898
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Trial to Evaluate the Efficacy, Safety and Tolerability of HZN-825 in Subjects With Idiopathic Pulmonary Fibrosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: HZN-825|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Behavioral Economics-Based Telehealth Intervention to Improve Post-MI Medication Adherence
Status: COMPLETED
Conditions: Myocardial Infarction, Acute|Myocardial Infarction
Interventions: BEHAVIORAL: Financial Incentive and Mobile Phone App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Iron Treatment for Young Children With Non-anemic Iron Deficiency
Status: COMPLETED
Conditions: Non-anemic Iron Deficiency
Interventions: DIETARY_SUPPLEMENT: Ferrous Sulfate|DIETARY_SUPPLEMENT: Placebo|BEHAVIORAL: Dietary counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of CYP450 Activities in Diabetic Patients vs. Non-diabetic Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: CRCHUM-MT cocktail
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: suPAR-guided Anakinra Treatment for Validation of the Risk and Management of Respiratory Failure by COVID-19 (SAVE)
Status: COMPLETED
Conditions: COVID-19|Virus Diseases|Corona Virus Infection|Lower Respiratory Tract Infection Viral
Interventions: DRUG: Anakinra
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Metabolic Effects of Natriuretic Peptide Hormones
Status: TERMINATED
Conditions: Obesity|Cardiovascular Physiological Phenomena|Metabolism
Interventions: DRUG: recombinant human BNP(1-32)|DRUG: placebo (control, normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Clinical Trial for Self-Injurious Behavior
Status: ENROLLING_BY_INVITATION
Conditions: Self-Injurious Behavior
Interventions: BEHAVIORAL: Noncontingent Reinforcement (NCR)|BEHAVIORAL: Combination Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DCVAC/OvCa After Standard-of-care Chemotherapy in Women With Relapse of Platinum-sensitive Epithelial Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer Recurrent
Interventions: BIOLOGICAL: DCVAC/OvCa|DRUG: Standard of Care Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: QUILT-3.049: NANT Triple Negative Breast Cancer (TNBC) Vaccine: Combination Immunotherapy in Subjects With TNBC Who Have Progressed on or After Anthracycline-based Chemotherapy
Status: WITHDRAWN
Conditions: Triple Negative Breast Cancer
Interventions: BIOLOGICAL: avelumab|BIOLOGICAL: bevacizumab|DRUG: capecitabine|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: 5-Fluorouracil|DRUG: Leucovorin|DRUG: nab-paclitaxel|DRUG: Lovaza|RADIATION: Stereotactic Body Radiation Therapy|BIOLOGICAL: ALT-803|BIOLOGICAL: ETBX-011|BIOLOGICAL: ETBX-051|BIOLOGICAL: ETBX-061|BIOLOGICAL: GI-4000|BIOLOGICAL: GI-6207|BIOLOGICAL: GI-6301|BIOLOGICAL: haNK
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Self-Care of Behavioral Variant Frontotemporal Dementia Caregivers
Status: COMPLETED
Conditions: Behavioral Variant of Frontotemporal Dementia|Caregiver Stress Syndrome
Interventions: BEHAVIORAL: Health Information + Health Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylaxis Versus on Demand Treatment for Children With Hemophilia A
Status: COMPLETED
Conditions: Hemophilia A
Interventions: BIOLOGICAL: Recombinant Factor VIII (Kogenate FS, BAY14-2222)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robot-based Rehabilitation of Upper Limb Impairment in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DEVICE: Physioassistant: Haptic training|DEVICE: Physioassistant: Sensorimotor training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Hydrochloride, Cisplatin, and Temsirolimus as First-Line Therapy in Treating Patients With Locally Advanced and/or Metastatic Transitional Cell Cancer of the Urothelium
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter|Urethral Cancer
Interventions: DRUG: cisplatin|DRUG: gemcitabine hydrochloride|DRUG: temsirolimus|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Traditional Mat Exercises Versus Reformer Pilates and Hammock Yoga on Chronic Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Reformer Pilates|OTHER: Hammock Yoga|OTHER: Traditional mat exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Right Care, for the Right Patient, at the Right Time, by the Right Provider: A Value-based Comparison of the Management of Ambulatory Patients With Acute Health Concerns in walk-in Clinics, Primary Care Physician Practices and Emergency Departments
Status: RECRUITING
Conditions: Ambulatory Care|Emergency Services, Hospital|Quality of Care|Costs
Interventions: OTHER: On-site recruitment (information and consent) following a random sampling recruitment schedule|OTHER: First phone call 1-3 days after the initial visit|OTHER: Second phone call 8-14 days after the initial visit
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Probiotics on the Preterm Delivery Rate in Pregnant Women at High Risk for Preterm Birth
Status: COMPLETED
Conditions: Preterm Birth
Interventions: DIETARY_SUPPLEMENT: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness Study of Tumor Cell-derived Microparticles to Treat Malignant Ascites and Pleural Effusion
Status: UNKNOWN
Conditions: Malignant Pleural Effusion,|Malignant Ascites
Interventions: OTHER: Drug-packaging microparticles
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III, Randomised, Double-blind, Placebo-controlled, Parallel Group Study of Six Months Treatment With Ropinirole PR as Adjunctive Therapy in Patients With Parkinson's Disease Who Are Not Optimally Controlled on L-Dopa
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: ReQuip PR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RT-PCR on Conjunctival Sample for the Detection of SARS-CoV-2 in Patients With Covid-19
Status: UNKNOWN
Conditions: SARS-CoV Infection|Pinkeye
Interventions: DIAGNOSTIC_TEST: conjunctival RT PCR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study Evaluating the Safety, Tolerability, and Activity of ICM-203 in Subjects With Knee Osteoarthritis.
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: GENETIC: ICM-203
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Bipolar Versus Ultrasonic Hemostasis Techniques in Thyroidectomy
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: PROCEDURE: Bipolar Versus Ultrasonic Hemostasis Techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The GUARD Trial - Part 1: A Phase 3 Clinical Trial for Prevention of Proliferative Vitreoretinopathy
Status: COMPLETED
Conditions: Proliferative Vitreoretinopathy
Interventions: DRUG: ADX-2191 (intravitreal methotrexate 0.8%)|OTHER: Standard surgical care procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Gemcitabine-Cisplatin Chemotherapy Plus Necitumumab in the First-Line Treatment of Participants With Squamous Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Necitumumab|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of PuraSinus Versus Bioresorbable Nasal Dressings
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Sinus Disease|Surgery
Interventions: DEVICE: PuraSinus|DEVICE: Bioresorbable Nasal Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis
Status: RECRUITING
Conditions: Takayasu's Arteritis|Giant Cell Arteritis|Polyarteritis Nodosa|Relapsing Polychondritis|ANCA-Associated Vasculitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Novel Neoadjuvant and Adjuvant Strategy for Germline BRCA 1/2 Mutated Triple Negative Breast Cancer
Status: RECRUITING
Conditions: Triple Negative Breast Neoplasms|Triple Negative Breast Cancer|Breast Neoplasms|Breast Cancer|BRCA1 Mutation|BRCA2 Mutation|BRCA Mutation|BRCA-Associated Breast Carcinoma
Interventions: DRUG: Pembrolizumab|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Olaparib|PROCEDURE: Definitive Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Synthetic MVA-based SARS-CoV-2 Vaccine, GEO-CM04S1, for the Prevention of COVID-19 Infection
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19 Infection
Interventions: DRUG: Placebo Administration|BIOLOGICAL: Synthetic MVA-based SARS-CoV-2 Vaccine COH04S1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Upper Back Strengthening and Postural Correction in Pregnant Females With Costal Rib Pain
Status: COMPLETED
Conditions: Chest Pain
Interventions: OTHER: Upper back strengthening and Postural correction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Nimotuzumab,Capecitabine and Radiotherapy for Inoperable or Recurrent Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer|Concurrent Chemoradiotherapy
Interventions: DRUG: nimotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: South Danish Diabetes Study: Evaluation of the Antidiabetic Treatment of Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Insulin Aspart|DRUG: Insulin NPH|DRUG: Metformin|DRUG: Rosiglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Inflammatory Markers (VNN1) in Crohn Disease and Ulcerative Colitis.
Status: UNKNOWN
Conditions: Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis)
Interventions: PROCEDURE: Colonoscopy for biopsies samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: I-124 PET/CT Imaging and Dosimetry for RAI-Naïve or Refractory Thyroid Cancer
Status: RECRUITING
Conditions: Thyroid Cancer|RAI-Refractory Thyroid Cancer
Interventions: DIAGNOSTIC_TEST: Disease status detection|DIAGNOSTIC_TEST: Theranostic dosimetry|DRUG: I-124 PET/CT imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Diclofenac Patch for Treatment of Acute Pain Due to Mild to Moderate Soft Tissue Injuries (TAPED)
Status: COMPLETED
Conditions: Acute Pain|Soft Tissue Injury
Interventions: DRUG: Diclofenac Sodium|DRUG: Matching Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: International Study of Inflammation in COVID-19
Status: COMPLETED
Conditions: Covid19|Outcome, Fatal|Respiratory Failure|Acute Kidney Injury|Inflammation
Interventions: DIAGNOSTIC_TEST: SuPAR, C-reactive protein, Ferritin, D-Dimer, Procalcitonin, Interleukin-6, Lactate Dehydrogenase
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of SRX246 on an Experimental Model of Fear and Anxiety in Humans
Status: UNKNOWN
Conditions: Fear|Anxiety
Interventions: DRUG: SRX246|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Salvage Brachytherapy and Interstitial Hyperthermia for Locally Recurrent Prostate Carcinoma Following Radiation Therapy
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: RADIATION: Brachytherapy|OTHER: Hyperthermia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digital Versus Telephone Symptom Assessment and Triage in Primary Care
Status: RECRUITING
Conditions: Infections|Injuries|Psychiatric Disorder|Gastro-Intestinal Disorder|Skin Diseases
Interventions: BEHAVIORAL: Digital triage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Collection of Blood Samples for New Diagnostic Devices 2
Status: RECRUITING
Conditions: Embolism and Thrombosis|Cardiovascular|Renal|Inflammation|Infections
Interventions: DIAGNOSTIC_TEST: Venous blood draw|DIAGNOSTIC_TEST: Fingerstick
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: COMP.ACT for Chronic Pain Exercises in an ACT Group Intervention for Chronic Pain
Status: UNKNOWN
Conditions: Chronic Pain
Interventions: BEHAVIORAL: Acceptance & Commitment Therapy + Compassion (COMP.ACT)|BEHAVIORAL: Acceptance and Commitment Therapy (ACT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Six Months Evaluation of Next Science Acne Creams on Facial Acne in Adult Females.
Status: TERMINATED
Conditions: Acne Vulgaris
Interventions: DRUG: Acne cream 2X|DRUG: Acne cream 1X
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pectoral Blocks on Perioperative Pain in Gender Affirmation Top Surgery
Status: COMPLETED
Conditions: Gender Dysphoria|Opioid Use|Pain, Postoperative
Interventions: DRUG: Ropivacaine 0.2% Injectable Solution|OTHER: Saline (0.9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Motivational Interviewing to Enhance Behavioral Change in Older Adults With Hoarding Disorder
Status: RECRUITING
Conditions: Hoarding Disorder
Interventions: BEHAVIORAL: RECLAIM: Reducing Clutter and Increasing Meaning|BEHAVIORAL: Sorting Practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Novel Prescription Digital Therapeutic Supporting Unobserved Buprenorphine Initiation & Adherence
Status: COMPLETED
Conditions: Opioid Use Disorder
Interventions: DEVICE: PEAR-002B|DEVICE: reSET-O
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sham-Controlled RCT on 10kHz High-Frequency Spinal Cord Stimulation for Chronic Neuropathic Low Back Pain (Modulate-LBP)
Status: TERMINATED
Conditions: Chronic Low Back Pain|Neuropathic Pain|Refractory Pain
Interventions: DEVICE: Nevro Senza System (HF10 Therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Recombinant Human Tumor Necrosis Factor-α Receptor Ⅱ Fusion Protein in the Treatment of Acute Gout
Status: NOT_YET_RECRUITING
Conditions: Acute Gout
Interventions: DRUG: rhTNFR-Fc|DRUG: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MK-0893 on Glucagon-Induced Glycemic Excursion in Healthy Male Participants Following Intravenous Administration of Glucagon, Sandostatine® and Insulin (MK-0893-002)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: MK-0893 10 mg|DRUG: MK-0893 40 mg|DRUG: MK-0893 200 mg|DRUG: MK-0893 1000 mg|DRUG: Placebo|BIOLOGICAL: Sandostatine®|BIOLOGICAL: Insulin|BIOLOGICAL: Glucagon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Insomnia in Patients With Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Insomnia
Interventions: OTHER: Tilia tomentosa Concentrated - Glycerine macerate (C-GM) vs Placebo (1 gtt/10 kg/day before bedtime for 15 days)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT