pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Erlotinib, Celecoxib and Reirradiation for Recurrent Head and Neck Cancer
Status: COMPLETED
Conditions: Cancer of the Pharynx|Cancer of the Larynx|Cancer of the Neck|Paranasal Sinus Neoplasms|Cancer of the Head
Interventions: DRUG: erlotinib + celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment and Outcome of Early Onset Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Lithium|DRUG: Olanzapine|DRUG: Divalproex|DRUG: Risperidone|DRUG: Quetiapine|DRUG: Ziprasidone|DRUG: Aripriprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The ACTonHEART Study: Design of a Randomized Controlled Clinical Trial of Acceptance and Commitment Therapy for Cardiac Patients
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: BEHAVIORAL: ACT-based intervention|BEHAVIORAL: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Liquid Certolizumab Pegol as Additional Medication to Methotrexate in the Treatment of Signs and Symptoms of Rheumatoid Arthritis and in Prevention of Joint Damage in Patients With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Certolizumab Pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Tandutinib in Treating Patients Who Have Undergone Surgery for Metastatic Kidney Cancer
Status: COMPLETED
Conditions: Clear Cell Renal Cell Carcinoma|Recurrent Renal Cell Cancer|Stage IV Renal Cell Cancer
Interventions: DRUG: tandutinib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of Stenosis Assessment by Coronary Artery Computed Tomography Against Invasive Measurements of Fractional Flow Reserve in Patients With Significant Coronary Artery Stenoses
Status: COMPLETED
Conditions: Coronary Artery Stenosis
Interventions: PROCEDURE: FFR, IVUS, VH, or combination of the three
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparisons Of The Bioavailability And Pharmacodynamics Of Various Formulations Of MOA-728 In Subjects On Methadone
Status: COMPLETED
Conditions: Metahdone-maintenance Subjects
Interventions: DRUG: MOA-728
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Early Abuse on Adult Intimate Relationships
Status: COMPLETED
Conditions: Hypoactive Sexual Desire Disorder|Female Sexual Arousal Disorder|Female Orgasmic Disorder|Major Depressive Disorder|Post-traumatic Stress Disorder
Interventions: BEHAVIORAL: Expressive writing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a One Time Dose of Cholecalciferol on Serum Concentration of 25-Hydroxyvitamin D and Macrophages
Status: COMPLETED
Conditions: Inflammation
Interventions: DIETARY_SUPPLEMENT: Arm 2: cholecalciferol 50,000 IU|DIETARY_SUPPLEMENT: Arm 3: cholecalciferol 100,000 IU|DIETARY_SUPPLEMENT: Arm 4: cholecalciferol 200,000 IU|OTHER: Arm 1: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Dose Escalation Study of Intravenous VCN-01 With or Without Gemcitabine and Abraxane® in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Locally Advanced Solid Tumors|Metastatic Solid Tumors|Pancreatic Adenocarcinoma
Interventions: GENETIC: VCN-01|DRUG: Gemcitabine|DRUG: Abraxane®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sonication-based OCD Neurosurgical Intervention Via Capsulotomy
Status: NOT_YET_RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: ExAblate MR-guided Focused Ultrasound Bilateral Anterior Capsulotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First in hUman Study for Resistant Epilepsy With the Vagus Nerve stimulatiOn Device by syneRgia medicAl
Status: NOT_YET_RECRUITING
Conditions: Drug Resistant Epilepsy
Interventions: DEVICE: VNS Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety Study of QAW039 in the Treatment of Patients With Moderate to Severe Atopic Dermatitis.
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: QAW039|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Shaolin Dan Tian Breathing Fosters Relaxed and Attentive Mind
Status: UNKNOWN
Conditions: Attention|Electroencephalography
Interventions: BEHAVIORAL: Dan Tian Breathing|BEHAVIORAL: Progressive muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Physical Therapy and Dalfampridine on Functional Mobility in Non Ambulatory Persons With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Dalfampridine Pill|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: BEYOND: Betaferon/Betaseron Efficacy Yielding Outcomes of a New Dose in Multiple Sclerosis (MS) Patients
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Interferon beta-1b (Betaferon/Betaseron, BAY86-5046)|DRUG: Interferon beta-1b (Betaferon/Betaseron, BAY86-5046)|DRUG: Copaxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Once Daily Dosing to Improve Medication Adherence and Patient Satisfaction in Kidney Transplant Recipients
Status: ACTIVE_NOT_RECRUITING
Conditions: End-Stage Renal Disease
Interventions: DRUG: Conversion to Advagraf|DRUG: conversion of non-immunosuppressant drugs to once daily|DRUG: Conversion to once daily MPA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Training and Follow-up Given According to the Health Promotion Model on Relactation Success
Status: COMPLETED
Conditions: Breastfeeding
Interventions: BEHAVIORAL: Education|BEHAVIORAL: Follow-up|BEHAVIORAL: Referral to Lactation and Relactation Polyclinic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Evaluation of PROPEL® Contour Sinus Implant
Status: COMPLETED
Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: DEVICE: PROPEL Contour Sinus Implant|PROCEDURE: Balloon Sinus Dilation Alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MAX-40279combined With KN046 in Patients With Advanced / Metastatic Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced / Metastatic Solid Tumors
Interventions: DRUG: MAX-40279-01: 50mg/70mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DOAC in Unusual Site Venous Thrombosis
Status: RECRUITING
Conditions: Splanchnic Vein Thrombosis|Cerebral Vein Thrombosis|Ovarian Vein Thrombosis|Renal Vein Thrombosis|Retinal Vein Thrombosis
Interventions: DRUG: Direct Oral Anticoagulants
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Dexlansoprazole Delayed-Release Capsules in Treating Symptomatic Non-Erosive Gastroesophageal Reflux Disease in Adolescents
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: Dexlansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRI With Gadoxetate Disodium in Measuring Tumors in Patients With Liver Cancer
Status: COMPLETED
Conditions: Adult Hepatocellular Carcinoma|Advanced Adult Hepatocellular Carcinoma|BCLC Stage 0 Adult Hepatocellular Carcinoma|BCLC Stage A Adult Hepatocellular Carcinoma|BCLC Stage B Adult Hepatocellular Carcinoma|BCLC Stage C Adult Hepatocellular Carcinoma|BCLC Stage D Adult Hepatocellular Carcinoma|Localized Non-Resectable Adult Liver Carcinoma|Localized Resectable Adult Liver Carcinoma
Interventions: DRUG: Gadoxetate Disodium|DEVICE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluate the Safety and Performance of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial Surgery
Status: COMPLETED
Conditions: Cerebrospinal Fluid Leak
Interventions: DEVICE: Dura Sealant Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial Comparing ERCP vs ERCP and Transmural Gall Bladder Drainage
Status: RECRUITING
Conditions: Bile Duct; Obstruction, With Calculus|Choledocholithiasis
Interventions: PROCEDURE: Gall bladder transmural drainage with LAMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Proof of Concept Study to Assess Effect of Fluticasone Furoate (FF)/Levocabastine Fixed Dose Combination (FDC) Compared With Levocabastine and FF Alone in Subjects With Allergic Rhinitis (AR)
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial and Seasonal
Interventions: DRUG: FF/levocabastine|DRUG: FF|DRUG: levocabastine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Low-dose Colchicine With or Without Stepwise Dose Titration of Febuxostat for Flare Prophylaxis in Gout
Status: TERMINATED
Conditions: Gout
Interventions: DRUG: Stepwise dose titration of febuxostat and low-dose colchicine|DRUG: Fixed dose febuxostat and low-dose colchicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease
Status: NOT_YET_RECRUITING
Conditions: Diabetic Nephropathies|Kidney Failure, Chronic|Diabetes Mellitus Type 1|Heart Failure
Interventions: DRUG: Sotagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Diameter of the Middle Cerebral Artery Measured With Magnetic Resonance Angiography
Status: COMPLETED
Conditions: Headache|Migraine|MR-Angiography|Healthy Volunteers|GTN|Middle Cerebral Artery
Interventions: DEVICE: MR-angiography, GTN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dose Escalation of Clofarabine in Combination With Cytarabine and Idarubicin as Induction Therapy in High Risk AML
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: clofarabine, cytarabine, idarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraocular Pressure and Optic Nerve Sheath Diameter Changes at Different PEEP Levels
Status: TERMINATED
Conditions: Intraocular Pressure|Intracranial Pressure|Positive End-expiratory Pressure
Interventions: OTHER: Positive end-expiratory pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Tolerability and Pharmacokinetics of Lumateperone in Pediatric Patients With Autism Spectrum Disorder
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Lumateperone 10.5 mg capsule|DRUG: Lumateperone 21 mg capsule|DRUG: Lumateperone 5 mg ODT|DRUG: Lumateperone 10.5 mg ODT|DRUG: Lumateperone 15.5 mg ODT|DRUG: Lumateperone 21 mg ODT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploration of Therapeutic Strategies for NeoRAS Wild-type Metastatic Colorectal Cancer Based on Circulating Tumor DNA
Status: RECRUITING
Conditions: Colorectal Cancer Metastatic
Interventions: DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Icrucumab (IMC-18F1) or Ramucirumab Drug Product (DP) in Combination With Capecitabine or Capecitabine on Previously Treated Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: Ramucirumab DP|BIOLOGICAL: IMC-18F1|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-Florbetaben PET Amyloid Imaging in Case of Intermediate CSF Biology for the Diagnosis of Alzheimer's Disease : a Pilot Study
Status: COMPLETED
Conditions: Amyloid PET Imaging
Interventions: DEVICE: 18F-Florbetaben PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Suberoylanilide Hydroxamic Acid (Vorinostat, MK-0683) Versus Placebo in Advanced Malignant Pleural Mesothelioma (MK-0683-014)
Status: COMPLETED
Conditions: Mesothelioma|Lung Cancer
Interventions: DRUG: Vorinostat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of a Serious Game Targeting Interpersonal Emotion Regulation in Early Adolescents
Status: UNKNOWN
Conditions: Interpersonal Relations
Interventions: DEVICE: IER AG|DEVICE: BubbleShooter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Investigate Safety, Tolerability, PK and PD Response of SLN360 in Subjects With Elevated Lipoprotein(a)
Status: COMPLETED
Conditions: Hyperlipidemias|Dyslipidemias|Elevated Lp(a)
Interventions: DRUG: SLN360|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Standard Ultrasound Guidance vs. New Needle-steering Device in Subclavian Venous Catheterization
Status: RECRUITING
Conditions: Ultrasound Guidance|Central Venous Catheterization
Interventions: DEVICE: Subclavian venipuncture for catheter placement using the needle-steering device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety Of Spil's Estradiol Vaginal Tablet
Status: TERMINATED
Conditions: Vulvar Atrophy|Vaginal Atrophy
Interventions: DRUG: Estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Suberoylanilide Hydroxamic Acid in Treating Patients With Progressive Stage IV Breast Cancer
Status: TERMINATED
Conditions: Male Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: vorinostat|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Nitric Oxide After Out-of-Hospital Cardiac Arrest
Status: TERMINATED
Conditions: Heart Arrest, Out-Of-Hospital
Interventions: DRUG: Nitric Oxide|DRUG: Nitrogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HAIC Combined With Sintilimab and Bevacizumab for Unresectable Intrahepatic Cholangiocarcinoma
Status: RECRUITING
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DRUG: HAIC Combined with Tislelizumab and Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digoxin Dosing in Heart Failure: A Simplified Nomogram Versus Standard Care
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: Digoxin Dosing per Nomogram|DRUG: Digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Biobehavioral Stress Reduction Intervention in Patients With Triple Negative Breast Cancer
Status: RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|HER2-Negative Breast Carcinoma|Hormone Receptor-Negative Breast Carcinoma|Triple-Negative Breast Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Medical Chart Review|PROCEDURE: Stress Management Therapy|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD2066 in Young and Elderly Healthy Subjects
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: AZD2066|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Beta-Blockers and Aspirin on Hemostasis and Endothelial Function After Acute Mental Stress
Status: UNKNOWN
Conditions: Arteriosclerosis|Stress, Psychological
Interventions: DRUG: inderal (drug), acetylsalicylic acid (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Omega Galil Hazelnut Chocolate Spread "O'Sweet Spread" With 80% Reduced Sucrose on Glucose Response of People With TID
Status: RECRUITING
Conditions: Type1diabetes
Interventions: OTHER: Omega Galil Hazelnut Chocolate Spread "O'Sweet Spread"|OTHER: Active Control-Nutella hazelnut cocoa spread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Topical ASP-1001 (Contrast Media Formulation) and the Acute Response to Nasal Allergen Challenge (NAC)
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: ASP-1001 nasal spray|DRUG: Placebo for ASP-1001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of Hydrogel vs. Silicone Hydrogel Contact Lenses
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: ocufilcon D|DEVICE: omafilcon A|DEVICE: methafilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Tranexamic Acid 5%,5ml/amp|DRUG: Tranexamic Acid 5%,5ml/amp|DRUG: rivaroxaban (10mg)|DRUG: 0.9% Normal Saline|DRUG: 0.9% Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intraoperative Dexamethasone Implant Improves Outcome of Cataract Surgery With Diabetic Macular Edema
Status: COMPLETED
Conditions: Macular Edema, Cystoid|Vision Disorders|Diabetic Macular Edema|Cystoid Macular Edema Following Cataract Surgery|Cataract
Interventions: DRUG: Dexamethasone Drug delivery system (Ozurdex)|PROCEDURE: Cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An International, Multicentric, Prospective, Observational Study to Evaluate Monosyn® Suture Material for Anastomoses in the Gastrointestinal Tract
Status: TERMINATED
Conditions: C.Surgical Procedure; Digestive System|Symptomatic Disorders of the Gastrointestinal Tract|Gastric Anastomosis (Site)|Gastrointestinal Neoplasms
Interventions: DEVICE: Monosyn
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Educational Intervention to Reduce Outpatient Inappropriate Transthoracic Echocardiograms
Status: COMPLETED
Conditions: Inappropriate Use of Echocardiography
Interventions: BEHAVIORAL: Educational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Shoulder Impingement Syndrome and Graded Motor Imagery
Status: RECRUITING
Conditions: Shoulder Pain|Shoulder Impingement Syndrome
Interventions: OTHER: Graded Motor Imagery|OTHER: Traditional Physiotherapy Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Anatomical Factors Upon Root Coverage
Status: COMPLETED
Conditions: Gingival Recession|Gingival Diseases|Periodontal Attachment Loss
Interventions: PROCEDURE: Coronally advanced flap and connective tissue graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Therapeutic Equivalence of SYN008 Versus Xolair® in the Treatment of Patients With Refractory Chronic Spontaneous Urticaria
Status: UNKNOWN
Conditions: Chronic Spontaneous Urticaria
Interventions: BIOLOGICAL: SYN008|BIOLOGICAL: Omalizumab for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Bulk-fill vs Layered Composite Resin in Class I and II Posterior Restorations
Status: UNKNOWN
Conditions: Dental Caries Class I (Disorder)|Dental Caries Class II
Interventions: DEVICE: Filtek Bulk Fill Posterior Restorative|DEVICE: Filtek Z350 XT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fenofibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cholangitis
Status: RECRUITING
Conditions: Primary Biliary Cholangitis
Interventions: DRUG: Fenofibrate|DRUG: Placebo|DRUG: UDCA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First-in-Human Single and Multiple Dose of GLPG1690
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG1690 single ascending doses|DRUG: Placebo single ascending doses|DRUG: GLPG1690, multiple ascending doses, oral suspension|DRUG: Placebo, multiple ascending doses, oral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate if Multiple Doses of Rifampicin Change the Blood Concentration of YM150 (Darexaban)
Status: COMPLETED
Conditions: Pharmacokinetics of Darexaban and Metabolites|Healthy Subjects
Interventions: DRUG: darexaban|DRUG: Rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Yellow Fever Vaccine on Statin/ Non Statin Subjects
Status: COMPLETED
Conditions: Yellow Fever Vaccine|Yellow Fever
Interventions: DRUG: Stamaril (live attenuated yellow fever vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Interpersonal Psychotherapy for Depressed Adolescents Engaging in Non-suicidal Self-injury
Status: COMPLETED
Conditions: Depression|Self-injurious Behavior
Interventions: BEHAVIORAL: Interpersonal Psychotherapy for Depressed Adolescents
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PED/PEA-15 Protein, PCOS, Obesity, Insulin Sensitivity Indexes, Metformin, Oral Contraceptives
Status: COMPLETED
Conditions: Polycystic Ovarian Syndrome|Insulin Sensitivity
Interventions: DRUG: Metformin|DRUG: oral contraceptive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Nicardipine to Treat Cerebral Vasospasm
Status: TERMINATED
Conditions: Cerebral Vasospasm
Interventions: DRUG: Nicardipine hydrochloride|DRUG: Preservative-free normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of CANnabidiol on Anxiety and GABAergic Function in Individuals With Fragile-X Syndrome
Status: NOT_YET_RECRUITING
Conditions: Fragile X Syndrome
Interventions: DRUG: CBD Oral Solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Aromatherapy in Laparoscopic Cholecystectomy Patients
Status: COMPLETED
Conditions: Cholecystectomy|Aromatherapy
Interventions: OTHER: Intervention group Lavender|OTHER: Intervention group Geranium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cabozantinib or Sunitinib Malate in Treating Participants With Metastatic Variant Histology Renal Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Neoplasms of Urinary Tract|Renal Cell Carcinoma|Chromophobe Renal Cell Carcinoma|Metastatic Renal Cell Carcinoma|Papillary Renal Cell Carcinoma|Renal Cell Carcinoma Associated With Xp11.2 Translocations/TFE3 Gene Fusions|Sarcomatoid Renal Cell Carcinoma|Stage IV Renal Cell Cancer AJCC v8|Unclassified Renal Cell Carcinoma
Interventions: DRUG: Cabozantinib|DRUG: Sunitinib Malate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Prophylactic Treatment With Antibiotics During Concomitant Chemoradiotherapy in Patients With Head and Neck Cancer to Prevent Aspiration Pneumonia
Status: UNKNOWN
Conditions: Head and Neck Cancer
Interventions: DRUG: amoxicillin/clavulanic acid suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Anesthesia on Quality of Recovery in Patients Undergoing Correctional Tibial Osteotomy - A Randomized Controlled Trial
Status: COMPLETED
Conditions: Short Stature|Osteoarthritis
Interventions: DRUG: propofol and remifentanil|DRUG: desflurane and remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: HLA-Identical Sibling Donor Bone Marrow Transplantation for Individuals With Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen
Status: UNKNOWN
Conditions: Sickle Cell Disease
Interventions: DRUG: Fludarabine monophosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Deep TMS H-Coil in the Treatment of Major Depression- Augmentation of Antidepressant Medication
Status: COMPLETED
Conditions: Major Depression
Interventions: DEVICE: Transcranial Magnetic Stimulation (TMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Differences in the Effectiveness of Electromagnetic Stimulation Therapy and Kegel Exercises Based on Compliance, Subjective - Objective Symptoms and Pelvic Floor Muscle Strength in Postpartum Stress Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence|Postpartum
Interventions: PROCEDURE: NOVAMAG NT-60|BEHAVIORAL: Kegel Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study the Safety and Effectiveness of Tadalafil on High Blood Pressure in the Blood Vessel Going From the Heart to the Lungs
Status: COMPLETED
Conditions: Hypertension, Pulmonary
Interventions: DRUG: tadalafil|DRUG: tadalafil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Compare Nebulized Amphotericin B and Nebulized Normal Saline as Maintenance in Patients With Chronic Pulmonary Aspergillosis
Status: RECRUITING
Conditions: Chronic Pulmonary Aspergillosis|CPA|Aspergilloma
Interventions: DRUG: Normal saline|DRUG: Amphotericin B deoxycholate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Antacids and Multivitamins on Raltegravir
Status: COMPLETED
Conditions: HIV
Interventions: DIETARY_SUPPLEMENT: Multivitamins|DIETARY_SUPPLEMENT: Sodium bicarbonate|DRUG: Maalox Plus extra|DRUG: Raltegravir 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Anti-SARS-CoV-2 Equine Antibody F(ab')2 Fragments (INOSARS) for Adult Patients With Mild COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Placebo|DRUG: Anti-SARS-CoV-2 equine immunoglobulin F(ab')2 fragments (INOSARS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Hypocaloric Diet Associated With tDCS on Weight Loss and Metabolic Profile
Status: UNKNOWN
Conditions: Prediabetes|Obesity|Weight Loss|Diabetes|Overweight
Interventions: DEVICE: Active tDCS|BEHAVIORAL: Hypocaloric diet|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Auricular Acupressure Relieves Constipation for Patients With Heart Failure in Hospital
Status: COMPLETED
Conditions: Heart Failure|Auricular Acupressure|Constipation|Quality of Life|Depression, Anxiety
Interventions: OTHER: auricular acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase IV Study to Evaluate Safety, Tolerability and Effectiveness of Rivastigmine Patch 15cm2 in Patients With Severe Dementia of the Alzheimer's Type.
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Rivastigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visual Health Evaluation of Natural Color Display Technology
Status: COMPLETED
Conditions: Chromatic Adaptation
Interventions: OTHER: The automatic color temperature adjustment mode equipped on terminal display devices can reduce the discrepancy between the color temperature of the device and the ambient light.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Thalidomide in Combination With Capecitabine in Patients With Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Thalidomide|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness, Immunogenicity and Safety of the Second Booster Dose of the Vaccine Against COVID-19 in the Elderly
Status: UNKNOWN
Conditions: COVID-19|Vaccine Adverse Reaction|Vaccine-Preventable Diseases
Interventions: BIOLOGICAL: ChAdOx1 nCoV-19 or Comirnaty or Janssen COVID-19 Vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Velcade, Nipent, Rituxan (VNR) in Subjects With Relapsed Follicular, Marginal Zone, and Mantle Cell Lymphoma
Status: WITHDRAWN
Conditions: Follicular Lymphoma|Marginal Zone Lymphoma|Mantle Cell Lymphoma
Interventions: DRUG: MTD of Velcade, Nipent and Rituxan established in Part 1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Structural Description of Skin Biopsies With Dynamic Full-field Optical Coherence Tomography on Suspected Basal Cell Carcinoma Lesions, a Pilot Study (DOCTOBA)
Status: COMPLETED
Conditions: Basal Cell Carcinoma|Tomography, Optical Coherence
Interventions: OTHER: Dynamic full-field optical coherence tomography analysis of skin biopsy or resection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized Comparison of Endocardial Versus Epicardial - From the Coronary Sinus - Left Ventricular Pacing for Resynchronization in Heart Failure.
Status: COMPLETED
Conditions: Heart Failure|Cardiomyopathy, Dilated|Coronary Disease
Interventions: DEVICE: Resynchronization using a transeptal approach|DEVICE: Resynchronization using a coronary sinus approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Low and Standard-dose Ticagrelor After Intervention for ACS Patients
Status: RECRUITING
Conditions: Acute Coronary Syndrome|Coronary Stent Implantation
Interventions: DRUG: Ticagrelor 60mg|DRUG: Ticagrelor 90mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COMPLEX Registry - A Prospective COhort Study to Describe the Management and Outcomes of Patients Presenting With compLEX and Calcified Coronary Artery Disease
Status: RECRUITING
Conditions: Coronary Disease|Coronary Artery Disease|Coronary Restenosis|Coronary Arteriosclerosis|Coronary Artery Calcification|Stable Chronic Angina|Angina Pectoris|Angina, Stable|Angina, Unstable|Stent Thrombosis
Interventions: DEVICE: Impact of current PCI techniques/ devices in complex coronary artery lesions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Panobinostat in Combination With Daratumumab, Bortezomib and Dexamethasone for the Treatment of Relapsed/Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: DRUG: Bortezomib|DRUG: Daratumumab and Hyaluronidase-fihj|DRUG: Dexamethasone|DRUG: Panobinostat Lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Life Interventions for Childhood Growth and Development In Tanzania
Status: COMPLETED
Conditions: Malnutrition|Stunting|Cognitive Development|Enteric Pathogens
Interventions: DRUG: Azithromycin Oral Liquid Product|DRUG: Nitazoxanide Oral Suspension|DIETARY_SUPPLEMENT: Nicotinamide|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Bioavailability Study of MELT-100 (Midazolam and Ketamine Sublingual) and IV Midazolam or Ketamine
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Midazolam injection|DRUG: Ketamine Injectable Product|DRUG: MELT-100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Study Of Celecoxib Or Diclofenac And Omeprazole For Gastrointestinal (GI) Safety In High GI Risk Patients With Arthritis
Status: COMPLETED
Conditions: Osteoarthritis|Arthritis, Rheumatoid
Interventions: DRUG: Celecoxib|DRUG: Diclofenac + Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiopulmonary Testing for Potential Pancreas Transplant Candidates
Status: ENROLLING_BY_INVITATION
Conditions: Cardiovascular Risk Factor|Diabetes Mellitus, Type 1|Pancreas Transplant; Complications
Interventions: DIAGNOSTIC_TEST: Cardiopulmonary exercise test (CPET)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A First-in-human (FIH) Combination Treatment Study With a Single Dose Level of BMC128
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer|Melanoma|Renal Cell Carcinoma
Interventions: DRUG: BMC128|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RAL+ATV/r in Comparison With TDF/FTC (or 3TC) +ATV/r in HIV Infected Patients
Status: UNKNOWN
Conditions: Chronic Infection With HIV
Interventions: DRUG: Ritonavir boosted Atazanavir|DRUG: Raltegravir|DRUG: TDF/FTC (or 3TC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subacromial Methylprednisolone Versus Ketorolac for Shoulder Impingement
Status: TERMINATED
Conditions: Subacromial Impingement|Subacromial Impingement Syndrome
Interventions: DRUG: Ketorolac Tromethamine|DRUG: Methylprednisolone Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pectoral Nerve Block During Mastectomy
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer Female|Pain, Postoperative
Interventions: PROCEDURE: PECs block during mastectomy|PROCEDURE: Sham block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PReventing the EffectS of Intubation on DEglutition
Status: TERMINATED
Conditions: Deglutition Disorders|Mechanical Ventilation Complication|Complication of Ventilation Therapy
Interventions: BEHAVIORAL: Exercise and sensory stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metabolic Therapy in Patients With Osteoporosis After Hip Fracture by an Orthopedic-rehabilitation-metabolic Team
Status: UNKNOWN
Conditions: Hip Fracture
Interventions: OTHER: matching an appropriate drug therapy to patients with osteoporotic hip fractures
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy, Temozolomide, and Lomustine in Treating Young Patients With Newly Diagnosed Gliomas
Status: COMPLETED
Conditions: Anaplastic Astrocytoma|Central Nervous System Neoplasm|Glioblastoma|Gliosarcoma|Spinal Cord Neoplasm
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Lomustine|RADIATION: Radiation Therapy|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Trial of PED-1 and PED-2 in Male Patients With Premature Ejaculation
Status: COMPLETED
Conditions: Premature Ejaculation
Interventions: DRUG: Clomipramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CPAP to Improve Swallow Function Post Total Laryngectomy
Status: COMPLETED
Conditions: Oropharyngeal Dysphagia|Laryngectomy; Status
Interventions: DEVICE: Continuous Positive Airway Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate Safety, Tolerability and PK of C-10355 and C-10358 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: C-10355|DRUG: C-10358|DRUG: Kalydeco
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 2b/3, Randomized, Observer-Blinded, Placebo-Controlled, Multicenter Clinical Study Evaluating the Efficacy and Safety of Investigational SARS-CoV-2 mRNA Vaccine CVnCoV in Adults 18 Years of Age and Older
Status: COMPLETED
Conditions: Covid19|SARS-CoV-2
Interventions: BIOLOGICAL: CVnCoV|BIOLOGICAL: Placebo|BIOLOGICAL: Authorized/licensed vaccines for preventing COVID-19 (AV) as standard of care through their national vaccination program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety, Tolerability and How YH002 Enters, Moves Through and Exits the Body in Subjects With Advanced Solid Malignancies
Status: COMPLETED
Conditions: Advanced Solid Malignancies
Interventions: DRUG: YH002
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Study in Healthy Males Investigating Safety, Pharmacokinetics and Pharmacodynamics of NNC126-0083 Compared to Norditropin® SimpleXx®
Status: COMPLETED
Conditions: Growth Hormone Disorder|Healthy
Interventions: DRUG: NNC126-0083|DRUG: Norditropin® SimpleXx®|DRUG: placebo|DRUG: NNC126-0083|DRUG: Norditropin® SimpleXx®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3437943 in Participants With Type 2 Diabetes Mellitus (T2DM)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: LY3437943|DRUG: Dulaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sirolimus in Treating Young Patients With Relapsed or Refractory Acute Leukemia or Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Leukemia|Lymphoma
Interventions: DRUG: sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of 3 Years of Exercise on Development of Atrial Fibrillation
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: BEHAVIORAL: High intensity exercise|BEHAVIORAL: Moderate intensity exercise|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Investigate Single Ascending Oral Doses of AZD5213 in Healthy Male and Non Fertile Female Subjects
Status: COMPLETED
Conditions: Tolerability
Interventions: DRUG: AZD5213|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Randomized Clinical Trial Assessing the Short Term Clinical Impact of Continuous vs Flash Glucose Monitoring in Children, Adolescents and Young Adults With Type 1 Diabetes
Status: UNKNOWN
Conditions: Type 1 Diabetes
Interventions: DEVICE: Guardian Connect, Medtronic|DEVICE: Abbott Diabetes Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Randomized Study of Intraocular Caliper-assisted Capsulotomy for Age-related Cataract Patients With Corneal Limbus Opacity
Status: UNKNOWN
Conditions: Cataract Extraction
Interventions: PROCEDURE: Intraocular caliper-assisted capsulotomy|PROCEDURE: Verion navigation system-assisted capsulotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Botensilimab Plus Balstilimab and Fasting Mimicking Diet Plus Vitamin C for Patients With KRAS-Mutant Metastatic Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastatic Colorectal Adenocarcinoma|Stage IV Colorectal Cancer AJCC v8
Interventions: BIOLOGICAL: Balstilimab|PROCEDURE: Biospecimen Collection|BIOLOGICAL: Botensilimab|PROCEDURE: Computed Tomography|OTHER: Dietary Intervention|PROCEDURE: Magnetic Resonance Imaging|DIETARY_SUPPLEMENT: Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT