pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of SP306 Given Intramuscularly Compared to DT Given Subcutaneously in Japanese Adolescents 11 - 12 Years Old
Status: COMPLETED
Conditions: Tetanus|Diphtheria|Pertussis
Interventions: BIOLOGICAL: Tdap: Tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine adsorbed|BIOLOGICAL: Diphtheria and Tetanus toxoids adsorbed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Learn How the Body Processes the Study Medicine Called Osivelotor (PF-07940367) in People With Loss of Liver Function
Status: RECRUITING
Conditions: Liver Diseases
Interventions: DRUG: Osivelotor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Crossover Study to Evaluate the Effect of Lemborexant Versus Placebo and Zolpidem on Postural Stability, Auditory Awakening Threshold, and Cognitive Performance in Healthy Subjects 55 Years and Older
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: LEM5|DRUG: LEM10|DRUG: ZOL|DRUG: PBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: "TRAcheostomy With Single Use Bronchoscopes vs. Conventional Bronchoscopes"
Status: COMPLETED
Conditions: Respiratory Insufficiency
Interventions: DEVICE: Single Use Bronchoscopy for PDT|DEVICE: Conventional Multi Use Bronchoscopy for PDT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib Plus Vitamin K1 Versus Sorafenib in Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Sorafenib 400mg twice daily + intravenous infusion ofVit K1|DRUG: Sorafenib 400 mg twice daily + Intravenousinfusion of placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Higher Protein Dosing in Critically Ill Patients
Status: COMPLETED
Conditions: Critical Illness|Malnutrition
Interventions: OTHER: Usual Protein/Amino Acid Group|OTHER: Higher Protein/Amino Acid Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: IA Injection of Rejoint Gel and PRP in Patients With Unilateral Knee OA
Status: UNKNOWN
Conditions: PRP|Knee Osteoarthritis
Interventions: BIOLOGICAL: PRP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Eltrombopag at Escalated Doses
Status: COMPLETED
Conditions: Immune Thrombocytopenia|Platelet Disorder
Interventions: DRUG: Eltrombopag|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognition in Allogeneic Stem Cell Transplanted Patients and Sports
Status: UNKNOWN
Conditions: Allogeneic Stem Cell Transplantation|Exercise Intervention
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Short Treatment Study of Aripiprazole in Pediatric Patients With Autistic Disorder
Status: COMPLETED
Conditions: Autistic Disorder
Interventions: DRUG: Placebo of Aripiprazole|DRUG: Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Arthroscopic Supraspinatus Tendon Tear Repair in Patients Over 60 Years With and Without Patch Augmentation.
Status: WITHDRAWN
Conditions: Rotator Cuff Tears
Interventions: DEVICE: Pitch Patch|DEVICE: ArthroFlex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of YH1177 in Patients With Otitis Media and Otorrhea
Status: TERMINATED
Conditions: Otitis Media|Otorrhea
Interventions: DRUG: piperacillin 4% + tazobactam 0.5% + dexamethasone 0.1%|DRUG: piperacillin 8% + tazobactam 1.0% + dexamethasone 0.1%|DRUG: piperacillin 2% + tazobactam 0.25%|DRUG: piperacillin 4% + tazobactam 0.5%|DRUG: piperacillin 8% + tazobactam 1.0%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Idarubicin at Different Dosages as Induction Therapy for Newly Diagnosed Acute Myeloid Leukaemia
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Idarubicin(8mg/m2) and cytosine arabinoside|DRUG: Idarubicin(10mg/m2), cytosine arabinoside
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability and Effect of Food on TAK-385 Tablet Formulations in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: TAK-385 T2 Formulation|DRUG: TAK-385 T4 Formulation B|DRUG: TAK-385 T4 Formulation C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HCG (Human Chorionic Gonadotropin) Priming for Thin Endometrium in IVF (in Vitro Fertilization)
Status: UNKNOWN
Conditions: Endometrial Thickness|Pregnancy Outcome
Interventions: DRUG: HCG (human chorionic gonadotropin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Five Fraction SABR Dose Escalation for Early Stage Squamous Cell Carcinoma of the Lung
Status: TERMINATED
Conditions: Lung Cancer
Interventions: RADIATION: Stereotactic Ablative Body Radiation (SABR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pomegranate Peel, German Chamomile or Their Combination on Gingivitis
Status: NOT_YET_RECRUITING
Conditions: Gingivitis
Interventions: DRUG: Chamomile extract mouthwash|DRUG: Pomegranate peel extract mouth wash|DRUG: Combination of 5% chamomile extract and pomegranate peel extract mouthwash|PROCEDURE: Scaling|DRUG: Scaling and Chlorohexidine mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Assessing Patient Confidence in Biologic Medications
Status: ACTIVE_NOT_RECRUITING
Conditions: Psoriasis
Interventions: BEHAVIORAL: Anecdotal Evidence|BEHAVIORAL: Research Study Evidence|BEHAVIORAL: Anecdotal + Research Study Evidence|BEHAVIORAL: No Evidence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of INS37217 Inhalation Solution in Mild to Moderate Cystic Fibrosis Lung Disease
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: denufosol tetrasodium (INS37217)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Mosapride on Gut Transit in Patients With Chronic Constipation or Constipated Irritable Bowel Syndrome and Healthy Subjects
Status: UNKNOWN
Conditions: Constipated Irritable Bowel Syndrome|Chronic Constipation|Healthy
Interventions: DRUG: Mosapride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of a Smart-Phone App for Patients With Advanced Renal Cell Carcinoma Undergoing Combination Immunotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma Stage IV
Interventions: OTHER: mHealth Smart Phone Application|BEHAVIORAL: eHEALS digital literacy test|BEHAVIORAL: Weekly Quiz|BEHAVIORAL: European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire|BEHAVIORAL: Patient Post Intervention Survey
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Crestal Bone Expansion Obtained With the Magnetic Mallet® During the Preparation of the Implant Site
Status: COMPLETED
Conditions: Edentulous Alveolar Ridge
Interventions: PROCEDURE: Crestal Bone Expansion obtained with the Magnetic Mallet®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of CM310 in Patients With Uncontrolled Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: BIOLOGICAL: Interleukin-4 receptor responders 1|BIOLOGICAL: Interleukin-4 receptor responders 2|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimising Newborn Nutrition During Therapeutic Hypothermia.
Status: COMPLETED
Conditions: Infant, Newborn|Asphyxia Neonatorum|Hypothermia, Induced|Parenteral Nutrition|Infant Nutrition|Necrotizing Enterocolitis|Neonatal Sepsis
Interventions: DIETARY_SUPPLEMENT: Received enteral (milk) feeds during therapeutic hypothermia|DIETARY_SUPPLEMENT: Enteral (milk) feeds withheld during therapeutic hypothermia|DIETARY_SUPPLEMENT: Received parenteral nutrition during therapeutic hypothermia|DIETARY_SUPPLEMENT: Did not receive parenteral nutrition during therapeutic hypothermia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Boosting Executive Function With Brain Exercise
Status: NOT_YET_RECRUITING
Conditions: Sedentary Behavior
Interventions: BEHAVIORAL: Moderate-intensity cycling|BEHAVIORAL: Vigorous-intensity cycling|BEHAVIORAL: Uninterrupted sitting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: CF41102 5-year Clinical Evaluation of Conelog® Implant With 7 mm Length
Status: UNKNOWN
Conditions: Dental Implants|Partial Edentulism
Interventions: DEVICE: short implants with splinted crowns|DEVICE: short implants with non-splinted crowns
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TAK-659 in Combination With Nivolumab in Participants With Advanced Solid Tumors
Status: TERMINATED
Conditions: Triple-Negative Breast Neoplasms|Carcinoma, Non-Small-Cell Lung|Head and Neck Carcinoma, Squamous Cell|Advanced Solid Tumors
Interventions: DRUG: TAK-659|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase II Randomized, Double-Blind, Placebo-Controlled Study of BMS-188667 (CTLA4Ig) in Patients With Psoriasis Vulgaris
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: CTLA4Ig / Abatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of HLX07 + HLX10 With or Without Chemotherapy Versus HLX10 With Chemotherapy in First Line sqNSCLC
Status: RECRUITING
Conditions: Squamous Non-small-cell Lung Cancer
Interventions: DRUG: HLX10+chemo|DRUG: HLX10+HLX07+chemo|DRUG: HLX10+HLX07
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of T-cell Repertoire in Patients With Acute Myeloid Leukemia Undergoing Donor Stem Cell Transplant
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Laboratory Biomarker Analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Single-centre Study to Investigate Safety and Efficacy of Tri-Solfen in Wound Debridement
Status: UNKNOWN
Conditions: Wounds Injuries|Anesthesia, Local
Interventions: DRUG: Tri-Solfen Gel (Lidocaine HCl, Bupivacaine HCl, Adrenaline Acid Tartrate /Cetrimide)|DRUG: EMLA cream|DRUG: Post Operative Analgesia (Paracetamol, Ibuprofen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Race on How a Single Dose of ASP3652 is Taken up, Metabolized and Distributed Through the Bodies of Young, Healthy Male and Female Subjects, and Its Safety and Tolerability
Status: COMPLETED
Conditions: Pharmacokinetics|Pharmacodynamics|Healthy Subjects|Effect of Race
Interventions: DRUG: ASP3652
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial to Determine the Efficacy and Safety of Presendin in IIH
Status: TERMINATED
Conditions: Idiopathic Intracranial Hypertension
Interventions: DRUG: Presendin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Spacing of Anti-TNF Drugs in Ankylosing Spondylitis With Low Disease Activity
Status: COMPLETED
Conditions: Spondyloarthritis
Interventions: DRUG: Adalimumab, Etanercept, Golimumab or infliximab|DRUG: Adalimumab, Etanercept, Golimumab or infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tamoxifen +/- GnRH Analogue vs Aromatase Inhibitor + GnRH Analogue in Male Breast Cancer Patients
Status: COMPLETED
Conditions: Male Breast Cancer
Interventions: DRUG: Tamoxifen|DRUG: Tamoxifen and GnRH analogue|DRUG: Exemestane and GnRH analogue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of a PN Regimen Containing n-3 Fatty Acid in Patients Considered After GI Surgery
Status: COMPLETED
Conditions: GI Cancer
Interventions: DRUG: MLF 541|DRUG: Lipofundin MCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Study of Isavuconazole and Tacrolimus
Status: COMPLETED
Conditions: Pharmacokinetics of Isavuconazole|Pharmacokinetics of Tacrolimus|Healthy Volunteers
Interventions: DRUG: isavuconazole|DRUG: tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Reducing Concurrent Opioid-Benzodiazepine Prescriptions
Status: UNKNOWN
Conditions: Adverse Drug Effect of Opioids|Adverse Drug Effect of Benzodiazepines
Interventions: BEHAVIORAL: E-mail Alert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Immunotherapy for Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Blast Phase Chronic Myelogenous Leukemia (BP CML), and Myelodysplastic Syndrome (MDS) Relapse After Allogeneic Transplantation
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: GM-CSF|BIOLOGICAL: Interferon-α-2b
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Post-Market Clinical Trial for Access and Visualization of the Oropharynx, Hypopharynx and Larynx During Transoral Procedures
Status: COMPLETED
Conditions: OSA|Oral Disease|Oropharyngeal Neoplasms|Hypopharyngeal Neoplasms
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dabigatran Etexilate in Patients With Mechanical Heart Valves
Status: TERMINATED
Conditions: Heart Valve Diseases
Interventions: DRUG: warfarin 1mg|DRUG: dabigatran etexilate intermediate dose|DRUG: dabigatran etexilate low dose|DRUG: warfarin 5mg|DRUG: dabigatran etexilate high dose|DRUG: warfarin 3mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Oropharyngeal Cancer
Interventions: DRUG: Cisplatin|DRUG: Durvalumab|PROCEDURE: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The PENTO Protocol in Medication-related Osteonecrosis of the Jaw
Status: RECRUITING
Conditions: Medication-related Osteonecrosis of the Jaw (MRONJ)
Interventions: DRUG: Pentoxifylline+Tocopherol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Nasal Continuous Positive Airway Pressure (N-CPAP) on Arterial pCO2 During Spinal Anesthesia
Status: COMPLETED
Conditions: Knee Replacement Surgery
Interventions: OTHER: Nasal Continuous Positive Airway Pressure (NCPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Interest of the Dosage of Adalimumab Serum Levels in Crohn's Disease Patients for Prevention of Postoperative Recurrence
Status: RECRUITING
Conditions: Crohn Disease
Interventions: OTHER: Immunomonitoring-based follow-up|OTHER: Standard follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluate the Role of Adding Amaryl to Non-Insulin Dependent Diabetes Mellitus Patients Unresponsive to Maximum Dose Metformin & Thiazolidinedione
Status: COMPLETED
Conditions: Diabetes Mellitus, Non-Insulin-Dependent
Interventions: DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis & Death
Status: COMPLETED
Conditions: Neonatal SEPSIS
Interventions: DRUG: Azithromycin|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence Study of 4 mg Glimepiride Tablet
Status: COMPLETED
Conditions: Glimepiride BE Study in Healthy Volunteers Under Fasting Condition
Interventions: DRUG: Group I (Test) : Glimepiride 4 mg tablet of PT Dexa Medica|DRUG: Group II (Reference) : glimepiride (Amaryl) 4 mg tablet of PT Sanofi Aventis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: HEME Home Transfusion Program
Status: NOT_YET_RECRUITING
Conditions: Leukemia|Myeloma|Myelodysplastic Syndromes|Hematologic Malignancy|Hematologic Diseases|Lymphoma
Interventions: BEHAVIORAL: HEME-Hospice Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chemotherapy and Bone Marrow Transplantation in Treating Patients Acute Myeloid With Leukemia or Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: busulfan|DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: cytarabine|DRUG: methotrexate|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: syngeneic bone marrow transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Traumatic Optic Neuropathy Treatment Trial (TONTT)
Status: COMPLETED
Conditions: Traumatic Optic Neuropathy
Interventions: DRUG: Recombinant human erythropoietin (EPO)|OTHER: Observation|DRUG: Methyl prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Monocultivar Coratina Extra Virgin Olive Oil in UC Patients
Status: UNKNOWN
Conditions: Ulcerative Colitis Chronic Mild
Interventions: COMBINATION_PRODUCT: Beclomethasone dipropionate in addition to MC-EVOO|COMBINATION_PRODUCT: Beclomethasone dipropionate in addition to refined oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chemo-immunotherapy Plus Thoracic Radiotherapy in Extensive Stage Small-cell Lung Cancer
Status: RECRUITING
Conditions: Small-cell Lung Cancer
Interventions: PROCEDURE: Thoracic radiotherapy|DRUG: Chemo-immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of SF1126 in Combination With Nivolumab in Patients With Advanced Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DRUG: SF1126|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Obinutuzumab (GA101; RO5072759) in Combination With Chemotherapy in Participants With Previously Untreated Chronic Lymphocytic Leukemia (CLL) (GALTON)
Status: COMPLETED
Conditions: Lymphocytic Leukemia, Chronic
Interventions: DRUG: Fludarabine|DRUG: Obinutuzumab|DRUG: Bendamustine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Bile Acids on GLP-1 Secretion After Roux-en-Y Gastric Bypass
Status: COMPLETED
Conditions: Severe Obesity
Interventions: OTHER: Water|DRUG: Ursodeoxycholic Acid|DRUG: Chenodeoxycholic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: MSB11022 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: MSB11022|DRUG: US-licensed Humira|DRUG: EU-approved Humira
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety, Reactogenicity, and Immunogenicity Study of a Self-Amplifying mRNA Influenza Vaccine in Healthy Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Influenza, Human
Interventions: BIOLOGICAL: sa-mRNA vaccine Dose 1|BIOLOGICAL: sa-mRNA vaccine Dose 2|BIOLOGICAL: sa-mRNA vaccine Dose 3|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Influence of Extracorporeal Circulation on Platelet Function of Patients Undergoing Cardiac Surgery
Status: COMPLETED
Conditions: Acquired Platelet Function Disorder
Interventions: DEVICE: Multiple electrode aggregometry analyses (Multiple Electrode Aggregometry, Multiplate(R), Verum Diagnostica, Munich, Germany)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hepcidin and Glucose Metabolism
Status: RECRUITING
Conditions: Iron Deficiency Anemia of Pregnancy|Iron Metabolism Disorders|Glucose Intolerance|Gestational Diabetes
Interventions: DIETARY_SUPPLEMENT: 100mg iron fumarate|DIETARY_SUPPLEMENT: Burgerstein Schwangerschaft & Stillzeit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Influenze of Approach in Reversed Shoulder Prosthesis
Status: COMPLETED
Conditions: Outcomes Assessments, Patients|Rotator Cuff Arthropathy
Interventions: PROCEDURE: Reverse Shoulder Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Muscle Training in Wheelchair Basketball Players
Status: COMPLETED
Conditions: Respiratory Muscles|Breathing Exercises|Athletic Performance|Athletes|Aerobic Capacity
Interventions: DEVICE: Inspiratory pressure-threshold muscle training device.|DEVICE: nspiratory pressure-threshold muscle training device.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Single Dose of Intravenous rhTNF-α and Liposomal Doxorubicin in Patients With Advanced Solid Tumors or Lymphomas
Status: WITHDRAWN
Conditions: Solid Tumors|Lymphomas
Interventions: DRUG: Recombinant human TNF-α|DRUG: Liposomal doxorubicin|DRUG: Caelyx|DRUG: Recombinant human TNF-α
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SirolimUs CoaTed Balloon for The TrEatment of Below The Knee Arterial Disease
Status: RECRUITING
Conditions: Peripheral Artery Disease|Atherosclerosis|Arterial Disease of Legs
Interventions: DEVICE: MagicTouch PTA Sirolimus drug coated balloon|DEVICE: POBA balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-Frequency REpetitive TRanscranial Magnetic Stimulation Combined With Endovascular Treatment in ACute Ischemic StrokE
Status: NOT_YET_RECRUITING
Conditions: Stroke, Acute Ischemic
Interventions: DEVICE: LF-rTMS|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Apical Enlargement to Different Preparation Sizes and Tapers on Pain and Bacterial Reduction in Necrotic Pulp
Status: NOT_YET_RECRUITING
Conditions: Necrotic Pulp
Interventions: OTHER: Root canal instrumentation EdgeFile X7 to size #35/0.06|OTHER: Root canal instrumentation EdgeFile X7 to size #45/0.04|OTHER: Root canal instrumentation EdgeFile X7 to size #45/0.06|OTHER: Root canal instrumentation EdgeFile X7 to size #35/0.04
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Human Milk-derived Fortification in Preterm Infants
Status: NOT_YET_RECRUITING
Conditions: Postnatal Growth Restriction|Necrotizing Enterocolitis
Interventions: DIETARY_SUPPLEMENT: Human milk-derived HMF|DIETARY_SUPPLEMENT: bovine milk-derived HMF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Ixazomib on the Latent HIV Reservoir
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV)
Interventions: DRUG: Ixazomib 1 MG|DRUG: Ixazomib 2 MG|DRUG: Ixazomib 3 MG|DRUG: Ixazomib 4 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DELPHI in Subjects at Risk for Stroke and Dementia
Status: COMPLETED
Conditions: Stroke|Hypertension|Diabete Mellitus|Dyslipidemias|Sleep Disorder|Smoking|Overweight and Obesity|Familial Alzheimer Disease|Atrial Fibrillation|Cardiac Disease|Cognitive Impairment|Transient Ischemic Attack
Interventions: DEVICE: DELPhI system
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tai Chi/Qigong for Subsyndromal Depression and Cognition in Older Age Bipolar Disorder
Status: UNKNOWN
Conditions: Bipolar Disorder
Interventions: BEHAVIORAL: Tai Chi/Qigong vs. Walking/Stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Deep Neuromuscular Block (NMB), Inhalation or TIVA on Pneumoperitoneum.
Status: COMPLETED
Conditions: Muscle Relaxation
Interventions: DRUG: rocuronium|DRUG: Sevoflurane|DRUG: remifentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men to Compare Two Different Oral Formulations of BI 1810631 and to Test How Food or Rabeprazole Influence the Amount of BI 1810631 in the Blood
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1810631 - trial formulation 1 (TF1)|DRUG: BI 1810631 - new formulation (NF)|DRUG: Rabeprazole sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcome of Surgery for Lumbar Spinal Stenosis - a Comparison of Data From Three National Quality Registries
Status: COMPLETED
Conditions: Spinal Stenosis|Intermittent Claudication
Interventions: PROCEDURE: Surgery for lumbar spinal stenosis in Norway|PROCEDURE: Surgery for lumbar spinal stenosis in Sweden|PROCEDURE: Surgery for lumbar spinal stenosis in Denmark
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Radial Artery Versus No-touch Saphenous Vein
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: No-touch vein graft|PROCEDURE: Radial artery graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LDL-Cholesterol Lowering Effect of KB2115 as Add on to Statin
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: KB2115
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Laser Acupuncture on Insulin Resistance in Obese Women With Polycystic Ovarian Syndrome
Status: NOT_YET_RECRUITING
Conditions: Polycystic Ovary Syndrome
Interventions: OTHER: low caloric diet|OTHER: Placebo laser acupoint stimulation|OTHER: Laser Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pooled Analysis of the Safety and Efficacy of MK-0431A and MK-0431A XR in Pediatric Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin Therapy (Alone or in Combination With Insulin) (MK-0431A-170/MK-0431A-289)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin plus metformin|DRUG: Placebo to metformin|DRUG: Metformin|DRUG: Placebo to sitagliptin plus metformin|DRUG: Sitagliptin plus metformin XR|DRUG: Placebo to metformin XR|DRUG: Insulin|DRUG: Placebo to sitagliptin plus metformin XR|DRUG: Metformin XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Financial Incentives to Promote Stimulant Abstinence in a Community-Based Syringe Exchange Program
Status: RECRUITING
Conditions: Stimulant Use
Interventions: BEHAVIORAL: Incentives for Abstinence|BEHAVIORAL: Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I, Exploratory, Intra-patient Dose Escalation Study to Investigate the Preliminary Safety, Pharmacokinetics, and Anti-tumor Activity of Pasireotide (SOM230) s.c.Followed by Pasireotide LAR in Patients With Metastaticmelanoma or Metastatic Merkel Cell Carcinoma
Status: COMPLETED
Conditions: Metastatic Melanoma and Merkel Cell Carcinoma
Interventions: DRUG: Pasireotide sub-cutaneous formulation|DRUG: Pasireotide lon acting release formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Concierge Model of CAE Plus LAI in Individuals With Schizophrenia at Risk for Treatment Non-adherence and Homelessness
Status: COMPLETED
Conditions: Psychotic Disorders|Schizophrenia|Schizoaffective Disorder|Medication Adherence|Medication Non-Adherence
Interventions: BEHAVIORAL: CAE-L
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study of Platelet-rich Plasma Promoting Tendon-bone Healing in Anterior Cruciate Ligament Reconstruction
Status: UNKNOWN
Conditions: Sports Injury
Interventions: DRUG: Platelet-Rich Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Novel Protein Ingredient Combined With Oral Nutritional Supplement on Appetite in Older Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Aging|Appetite Loss|Undernutrition
Interventions: DIETARY_SUPPLEMENT: Oral Nutritional Supplement|DIETARY_SUPPLEMENT: Oral Nutritional Supplement + Whey Protein Hydrolysate|DIETARY_SUPPLEMENT: Whey Protein Hydrolysate + still water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers for Intestinal Permeability in Patients With Constipation
Status: COMPLETED
Conditions: Intestinal Diseases|Irritable Bowel Syndrome|Constipation
Interventions: DIAGNOSTIC_TEST: Permeability measurement|PROCEDURE: Esophagogastroduodenoscopy|PROCEDURE: Flexible sigmoidoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 1b Master Trial to Investigate CPX-351 in Subjects With Previously Untreated Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: CPX-351|DRUG: Venetoclax|DRUG: Midostaurin|DRUG: Enasidenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Applied Four Times Daily in Subjects With Acute Blunt Trauma Injuries
Status: COMPLETED
Conditions: Acute Blunt Soft Tissue Injuries/Contusions
Interventions: DRUG: Diclofenac sodium|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketamine and Glutamate After Brain Injury : a Microdialysis Study
Status: UNKNOWN
Conditions: Head Trauma
Interventions: DRUG: Ketamine|DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Nicotine on Cognition in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: transdermal nicotine patch|DRUG: Transdermal Nicotine Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Expectorant Activity of Oral N-acetylcystein (NAC) in Patients With Stable Chronic Bronchitis
Status: COMPLETED
Conditions: Chronic Bronchitis
Interventions: DRUG: Oral N-acetycystein (NAC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Wound Infections in Breast Cancer Surgery After Preoperative Skin Preparation With Chlorhexidine vs. Povidone-iodine
Status: COMPLETED
Conditions: Wound Infection|Breast Neoplasms
Interventions: DRUG: Chlorhexidine|DRUG: Povidone-Iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Pharmacokinetics of Single Intravenous Doses of Peginesatide in Healthy Volunteers
Status: COMPLETED
Conditions: Anemia|Chronic Kidney Disease|Chronic Renal Failure|Cancer
Interventions: DRUG: Placebo|DRUG: peginesatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Patient-Derived Xenografts in Personalizing Treatment for Patients With Relapsed/Refractory Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Recurrent Mantle Cell Lymphoma|Refractory Mantle Cell Lymphoma
Interventions: OTHER: Best Practice|DRUG: Ibrutinib|OTHER: Patient Derived Xenograft|OTHER: Personalized Medicine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Low Energy Shock Wave Plus BotulinumToxin A in Treating Patients With Interstitial Cystitis
Status: UNKNOWN
Conditions: Interstitial Cystitis
Interventions: DRUG: BOTOX 100U in normal saline|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A SAD and MAD Study of the Safety, Tolerability, and Pharmacokinetics of ATH-1105
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: ATH-1105|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Risk Assessment and Management Program (RAMP) on Knee Osteoarthritis in Primary Care
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: BEHAVIORAL: Risk assessment and Management Programme - Knee Osteoarthritis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Open-label, Multiple-dose, Phase III Study of the Population Pharmacokinetics of I.V. Synercid in 75 Pediatric Patients
Status: TERMINATED
Conditions: Gram-Positive Bacterial Infections
Interventions: DRUG: Synercid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Major Depressive Disorder With Bilateral Theta Burst Stimulation
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DEVICE: Transcranial Magnetic Stimulation|DEVICE: Sham Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Temozolomide, Nedaplatin, Vincristine, and Radiotherapy as First-line Treatment in Newly Diagnosed Primary CNS Lymphoma
Status: UNKNOWN
Conditions: Central Nervous System Tumors
Interventions: RADIATION: Radiotherapy|DRUG: nedaplatin|DRUG: vincristine|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Early Enteral vs. Parenteral Nutrition on Risk of Gastric-Content Aspiration in Patients Requiring Mechanical Ventilation and Catecholamines
Status: TERMINATED
Conditions: Acute Respiratory Failure|Shock
Interventions: OTHER: Parenteral nutrition|OTHER: Enteral nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Neoadjuvant Carboplatin, Eribulin and Trastuzumab for Operable HER2 Positive Breast Cancer
Status: TERMINATED
Conditions: HER-2 Positive Breast Cancer
Interventions: DRUG: eribulin|DRUG: carboplatin|DRUG: trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Burn Healing and Analgesia With Propranolol
Status: COMPLETED
Conditions: Burns|Pain
Interventions: DRUG: Propranolol|DRUG: Placebo|DRUG: Propanolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Doses of HER-096 in Healthy Subjects
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: HER-096|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Parkinson's Disease Monotherapy With CVN424
Status: RECRUITING
Conditions: Parkinson's Disease
Interventions: DRUG: CVN424 150 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Niraparib in BAP1 and Other DNA Damage Response (DDR) Deficient Neoplasms (UF-STO-ETI-001)
Status: COMPLETED
Conditions: Mesothelioma|Uveal Melanoma|Renal Cell Carcinoma|Cholangiocarcinoma
Interventions: DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smoking Cessation Intervention: Effectiveness in Primary Care
Status: COMPLETED
Conditions: Tobacco Dependence
Interventions: DRUG: nicotine patch|DRUG: nicotine patch|DRUG: nicotine lozenge|DRUG: bupropion|DRUG: patch + lozenge|DRUG: bupropion + lozenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinial Application of Park et al.(The Knee 27 (2020) 1577-1584)'s Study
Status: WITHDRAWN
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: pulsed radiofrequency ablation to modifined points group|PROCEDURE: pulsed radiofrequency ablation to conventional points group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: the Effect of White Noise on Sucking and Baby Comfort
Status: UNKNOWN
Conditions: Sucking Behavior
Interventions: OTHER: Orhan OSMAN's track "Don't Let Your Baby Cry" in the "Kolik" album will be played on the music player.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study With Neoadjuvant mFOLFOX7 Plus Cetuximab to Determine the Surgical Conversion Rate for Unresectable Colorectal Cancer With Metastases Confined to the Liver
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: 5-FU|DRUG: oxaliplatin|DRUG: leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a CT-100 DiNaMo Component on Cognitive Functioning and Mood Symptoms
Status: COMPLETED
Conditions: Multiple Sclerosis|Mild Cognitive Impairment|Cancer
Interventions: OTHER: CT-100 DiNaMo|OTHER: Care-as-Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Autologous Platelet Rich Plasma on Low Back Pain
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: OTHER: PRP Treatment(P)|DRUG: Medication Treatment(Loxoprofen Sodium tablets,M)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Correlating Probiotic Dietary Supplements During Pregnancy With Maternal Microbiome Profiles
Status: COMPLETED
Conditions: Pregnancy Related
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long-term Treatment Study of MRA for Rheumatoid Arthritis (RA) From Study MRA012JP
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: MRA(Tocilizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bupivacaine Versus Lidocaine Local Anesthesia
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome|Trigger Finger
Interventions: DRUG: Bupivacaine|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors
Status: RECRUITING
Conditions: Advanced Gastrointestinal Stromal Tumors|Metastatic Cancer
Interventions: DRUG: CGT9486 plus sunitinib|DRUG: CGT9486|DRUG: Sunitinib|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flourish HEC to Prevent Recurrence of BV
Status: COMPLETED
Conditions: Bacterial Vaginosis
Interventions: DEVICE: Flourish HEC Vaginal Care System (contains a class II medical device plus other unregulated components)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Performance of BonyPid-1000™ in the Treatment of Gustilo I, II, IIIA and IIIB Tibial Open Fractures
Status: COMPLETED
Conditions: Tibial Fractures|Open Fractures
Interventions: DEVICE: BonyPid-1000|OTHER: Standard of Care (SOC) treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Albumin-bound Paclitaxel Combination With Capecitabine Versus Capecitabine Monotherapy in Paclitaxel/Docetaxel-resistant Advanced Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Albumin-bound paclitaxel plus capecitabine|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT