pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of Belimumab Administered Subcutaneously in Subjects With Systemic Lupus Erythematosus (SLE)
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: Belimumab 200 mg SC|DRUG: Standard therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer
Status: RECRUITING
Conditions: Ependymoma|Medulloblastoma|Glioblastoma|Primary Brain Tumor
Interventions: DRUG: Ibrutinib|DRUG: Indoximod|DRUG: Cyclophosphamide|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Cognitive and Physical Intervention to Reduce Head and Muscle Pain in Working Communities
Status: COMPLETED
Conditions: Headache Disorders|Headache|Neck Pain|Shoulder Pain
Interventions: BEHAVIORAL: Cognitive, behavioral, exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine and Propofol As Sole Sedative Agent for Patients Undergoing Arteriovenous Fistula Surgery
Status: UNKNOWN
Conditions: Arteriovenous Fistula
Interventions: DRUG: Propofol|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer
Status: TERMINATED
Conditions: Childhood Choroid Plexus Tumor|Childhood Medulloblastoma|Childhood Pineoblastoma|Childhood Soft Tissue Sarcoma|Childhood Supratentorial Primitive Neuroectodermal Tumor|Neuroblastoma|Osteosarcoma|Retinoblastoma|Wilms Tumor and Other Childhood Kidney Tumors|Recurrent/Refractory Childhood Hodgkin Lymphoma|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hydrogel Injection to Assist Endoscopic Submucosal Dissection
Status: COMPLETED
Conditions: Submucosal Tumor of Gastrointestinal Tract
Interventions: DEVICE: sodium alginate mixed with calcium lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in Healthy Volunteers to Investigate the Effects of Ketoconazole on the Pharmacokinetics of NKTR-118
Status: COMPLETED
Conditions: Bioavailability|Healthy Volunteers|Drug- Drug Interactions
Interventions: DRUG: NKTR-118|DRUG: Ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Aspiration in Acute Respiratory Failure Survivors 2
Status: RECRUITING
Conditions: Dysphagia|Aspiration
Interventions: DIAGNOSTIC_TEST: 3-Screenings Protocol|DIAGNOSTIC_TEST: FEES|DIAGNOSTIC_TEST: Tracheal Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase I Trial to Establish the Safety and Maximum Tolerated Dose of High-affinity Autologous BCMA-targeting Chimeric Antigen Receptor (CAR) T-cells in Patients With Relapsed and Refractory B-cell Malignancies
Status: RECRUITING
Conditions: Neoplasms|Relapsed Diffuse Large B-cell Lymphoma (DLBCL)|Refractory Diffuse Large B-cell Lymphoma (DLBCL)|Multiple Myeloma, Refractory|Multiple Myeloma in Relapse
Interventions: GENETIC: MDC-CAR-BCMA001 (BCMA directed CAR T-cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 2-level Cervical Disc Replacement Comparing Prodisc C SK & Vivo to Mobi-C
Status: RECRUITING
Conditions: Symptomatic Cervical Disc Disease
Interventions: DEVICE: prodisc C SK and/or Vivo|DEVICE: Mobi-C Cervical Disc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cholecalciferol Supplementation in Hemodialysis Patients
Status: COMPLETED
Conditions: Anemia|Hemodialysis Complication|Vitamin D Deficiency
Interventions: DRUG: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Standardized Home Exercise Prescription Education
Status: WITHDRAWN
Conditions: Behavior|Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: Musculoskeletal (MSK) Prescription Didactic Lectures|OTHER: Musculoskeletal (MSK) home exercise hand-outs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Testing MLN0128 (TAK-228) as Potentially Targeted Treatment in Cancers With mTOR Genetic Changes (MATCH - Subprotocol L)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Multiple Myeloma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Sapanisertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of Sunitinib With S-1 And Cisplatin For Gastric Cancer
Status: COMPLETED
Conditions: Stomach Neoplasms
Interventions: DRUG: Cisplatin|DRUG: S-1|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety, and Pharmacokinetics of Parscaclisib in Participants With Normal Renal Function and Renal Impairment.
Status: COMPLETED
Conditions: Advanced Malignancies
Interventions: DRUG: parsaclisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Swept-Source Optical Coherence Tomography for Noninvasive Retinal Vascular Imaging
Status: TERMINATED
Conditions: Retinal Vascular Disease
Interventions: DEVICE: Swept-Source Optical Coherence Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study to Compare Two Formulations of Mirikizumab (LY3074828) in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Mirikizumab Prefilled Syringe|DRUG: Mirikizumab Autoinjector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Yersinia Pestis Lateral Flow Immunoassay for Blood Samples
Status: UNKNOWN
Conditions: Plague|Plague, Bubonic|Plague, Pneumonic|Yersinia Pestis Plague|Yersinia Pestis; Bubo|Yersinia Pestis; Pneumonia|Yersinia Sepsis|Yersinia Pestis Infection|Bubo; Yersinia Pestis|Bubonic; Plague, Skin|Pneumonic Plague
Interventions: DIAGNOSTIC_TEST: Lateral Flow Assay for Pathogens of the Plague
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: THE EFFECT OF VITAMIN C ON POST-ORTHODONTIC TREATMENT RELAPSE
Status: RECRUITING
Conditions: Orthodontic Relapse
Interventions: BIOLOGICAL: Local Vitamin C injection|BIOLOGICAL: Oral Vitamin C supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Long-term Extension Trial of Asenapine in Subjects With Schizophrenia (Study P06125)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Asenapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Saccharomyces Cerevisiae on Improving the Effectiveness of Conventional Treatment of Vulvo-vaginal Candidiasis
Status: TERMINATED
Conditions: Vulvo-vaginal Candidiasis
Interventions: DIETARY_SUPPLEMENT: Saccharomyces cerevisiae|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacological Reduction of Right Ventricular Enlargement
Status: RECRUITING
Conditions: Tricuspid Regurgitation|Right Ventricular Dilatation
Interventions: DRUG: Carvedilol+Empagliflozin|DRUG: Carvedilol|DRUG: Empagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Remifentanil Plus Morphine or Morphine Alone for Postthoracotomy Pain
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Remifentanil+morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Immunogenicity and Safety of MVC-COV1901 Compared With AZD1222 in Adults Aged 18 Years and Above
Status: COMPLETED
Conditions: COVID-19 Vaccine
Interventions: BIOLOGICAL: MVC-COV1901|BIOLOGICAL: AZD1222
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The COMBINED Study to Integrate Health Behaviour Change for People With a Rotator Cuff Disorder
Status: COMPLETED
Conditions: Physiotherapy|Rotator Cuff Syndrome|Rotator Cuff Impingement Syndrome
Interventions: OTHER: The COMBINED approach
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Confirmatory Trial of SK-PC-B70M in Mild to Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: SK-PC-B70M
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety Study of ME1111 in Moderate to Severe Onychomycosis Patients
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: ME1111 solution|DRUG: Vehicle Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate and Gemcitabine in Treating Patients With Locally Advanced, Metastatic, or Recurrent Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of an Electronic System to Support Clinical Decisions in Adults With Type 2 Diabetes Mellitus.
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Clinical Decision Support System|OTHER: Usual care based on clinical practice guideline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Addressing Health Disparities in Engagement, Retention, and Utilization of PrEP Among South Florida Women of Color
Status: COMPLETED
Conditions: HIV Prevention|PrEP Adherence
Interventions: BEHAVIORAL: iENGAGE for PrEP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ablation of Perimitral Flutter Following Catheter Ablation of Atrial Fibrillation: Impact on Outcomes
Status: COMPLETED
Conditions: Atrial Fibrillation|Perimitral Flutter
Interventions: PROCEDURE: catheter ablation|PROCEDURE: catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Varying Methods of ALV003 Administration for the Treatment of Celiac Disease
Status: COMPLETED
Conditions: Celiac Disease
Interventions: BIOLOGICAL: ALV003|BIOLOGICAL: ALV003 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Effectiveness of 5 Different Mouthwashes in the Treatment of Generalised Gingivitis
Status: COMPLETED
Conditions: Gingivitis
Interventions: DRUG: Essential oils|DRUG: Essential oils in combination with chlorhexidine 0,12%|DRUG: Placebo mouthwash|DRUG: Chlorhexidine 0,20 % in combination with aroma oils|DRUG: Prebiotic|DRUG: Hydrogen peroxide 0,8 %
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Afternoon and Evening Light on Teenagers' Melatonin Levels, Alertness, Sleepiness and Sleep
Status: COMPLETED
Conditions: Healthy|Teenager|Healthy Lifestyle
Interventions: OTHER: Low light condition|OTHER: Moderate light condition|OTHER: High light condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bucillamine for the Treatment of Acute Gout Flare in Subjects With Moderate to Severe Gout
Status: COMPLETED
Conditions: Gout
Interventions: DRUG: Bucillamine|DRUG: Colchicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficay & Safety of Galcanezumab in the Prevention of Episodic Migraine- the EVOLVE-2 Study
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Galcanezumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: APG-115 in Combination With PD-1 Inhibitor in Patients With Advanced Liposarcoma or Advanced Solid Tumors
Status: RECRUITING
Conditions: Liposarcoma|Advanced Solid Tumor
Interventions: DRUG: APG-115|DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VAC071: A Study to Assess Efficacy of the ChAd63/MVA PvDBP Vaccines
Status: COMPLETED
Conditions: Malaria, Vivax
Interventions: BIOLOGICAL: ChAd63 PvDBP and MVA PvDBP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Nano-crystalline Hydroxyapatite Silica Gel in Management of Periodontal Intrabony Defects
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: BIOLOGICAL: Nano-crystalline hydroxyapatite silica gel|PROCEDURE: open flap debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemopreventive Therapy for Malaria in Ugandan Children
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: trimethoprim-sulfamethoxazole (TS; TMP/SMX)|DRUG: sulfadoxine-pyrimethamine (SP)|DRUG: dihydroartemisinin-piperaquine (DP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cycled Phototherapy: A Safer Effective Treatment for Small Premature Infants?
Status: UNKNOWN
Conditions: Hyperbilirubinemia|Premature Newborns|Extremely Low Birth Weight
Interventions: OTHER: phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase II Study to Evaluate the Efficacy and Safety of SHR-1314 in Lupus Nephritis
Status: UNKNOWN
Conditions: Lupus Nephritis
Interventions: DRUG: SHR-1314|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ruxolitinib and Methylprednisolone as a First-line Treatment for Macrophage Activation Syndrome
Status: UNKNOWN
Conditions: Macrophage Activation Syndrome
Interventions: DRUG: Ruxolitinib|DRUG: methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Refractory/Relapsed Non-Hodgkin Lymphoma With CD19-TriCART Cell Therapy
Status: UNKNOWN
Conditions: Non-hodgkin Lymphoma,B Cell
Interventions: BIOLOGICAL: CD19-TriCAR-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chidamide Plus DICE Regimen for Patients With Relapse or Refractory B-cell Non-Hodgkin's Lymphoma (NHL)
Status: UNKNOWN
Conditions: B-cell Non-Hodgkin's Lymphoma
Interventions: DRUG: Chidamide plus DICE Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: M-CHOP in Richter´s Syndrome
Status: RECRUITING
Conditions: Richter Syndrome|Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: Mosunetuzumab|DRUG: CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial of Exparel vs Saline in Opioid Reduction of Pain Management Following Lumbar Spine Surgeries.
Status: COMPLETED
Conditions: Lumbar Spine Degeneration
Interventions: DRUG: saline 0.9%|DRUG: Liposomal bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Generating Evidence on NonEpileptic, Stereotypical and Intermittent Symptoms (NESIS) in Chronic Subdural Hematomas
Status: RECRUITING
Conditions: Chronic Subdural Hematoma|Epilepsy; Seizure|Cortical Depression; Cortical Depolarization|Nonepileptic, Stereotypical and Intermittent Symptoms|NESIS
Interventions: DRUG: Topamax|DRUG: Levetiracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Amyloid Prediction in Early Stage Alzheimer's Disease From Acoustic and Linguistic Patterns of Speech - PAST Extension
Status: UNKNOWN
Conditions: Alzheimer Disease|Preclinical Alzheimer's Disease|Prodromal Alzheimer's Disease|Alzheimer's Disease (Incl Subtypes)|Mild Cognitive Impairment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluate the Efficacy and Safety of Orelabrutinib in Adult Patients With Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus, SLE
Interventions: DRUG: Orelabrutinib (Low Dose)|DRUG: Orelabrutinib (High Dose)|DRUG: Orelabrutinib Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exosomes and Immunotherapy in Non-Hodgkin B-cell Lymphomas
Status: RECRUITING
Conditions: Lymphoma, B-cell, Aggressive Non-Hodgkin (B-NHL)
Interventions: OTHER: blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Transcutaneous Electrical Nerve Stimulation (TENS) and Kinesio Taping in Patients With Lateral Epicondylitis
Status: COMPLETED
Conditions: Pain in Arm, Unspecified|Tenosynovitis Elbow|Lateral Epicondylitis (Tennis Elbow) Bilateral
Interventions: OTHER: Transcutaneous Electrical Nerve Stimulation (TENS)|OTHER: Sham Transcutaneous Electrical Nerve Stimulation (TENS)|OTHER: Kinesio Taping|OTHER: Sham Kinesio Taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gene Testing to Help in the Diagnosis and Treatment of Childhood Brain Tumors
Status: COMPLETED
Conditions: Brain Tumors|Central Nervous System Tumors
Interventions: GENETIC: DNA ploidy analysis|GENETIC: comparative genomic hybridization|GENETIC: cytogenetic analysis|GENETIC: fluorescence in situ hybridization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ofatumumab/Methylprednisolone and Ofatumumab/Lenalidomide for Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: High Dose Methylprednisolone (HDMP)|DRUG: Ofatumumab|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biodegradable Stent Implantation in Biliary Benign Strictures.
Status: COMPLETED
Conditions: Biliary Tract|Biliary Tract Diseases|Stenosis|Follow-Up Studies|Stents
Interventions: DEVICE: Percutaneous placement of biodegradable biliary stents
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Pharmacodynamic Interaction Between Gabapentin and Ethanol in Healthy Subjects
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: Placebo ethanol|DRUG: Ethanol|DRUG: Placebo|DRUG: Gabapentin|DRUG: Ethanol|DRUG: Placebo|DRUG: Gabapentin|DRUG: Placebo ethanol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Presence of Anti-RACH Antibodies and Neurocognitive Disorder in Myasthenic or Alzheimers's Patients.
Status: NOT_YET_RECRUITING
Conditions: Alzheimer Disease|Myasthenia
Interventions: PROCEDURE: Adults with Alzheimer's disease|PROCEDURE: Adults with Myasthenia|OTHER: Healhty controls
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Research Study for Latina Women With Breast Cancer
Status: COMPLETED
Conditions: Cancer, Breast|Cancer-related Problem/Condition|Quality of Life|Hormone Dependent Neoplasms|Adherence, Medication
Interventions: BEHAVIORAL: "My Guide" (psychoeducation & self-management program)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioequivalence Study Between GSK3542503 Hydrochlorothiazide + Amiloride Hydrochloride 50 mg: 5 mg Tablets and Reference Product in Healthy Adult Participants Under Fasting Conditions
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: GSK3542503 (HCTZ 50mg/Amiloride HCl 5mg tablets)|DRUG: Moduretic (HCTZ 50mg/Amiloride HCl 5mg tablets)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Using Pregnenolone to Treat Bipolar Depression
Status: COMPLETED
Conditions: Bipolar Disorder|Major Depressive Disorder
Interventions: DRUG: Pregnenolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Proprioceptive Neuromuscular Training on Sensory and Motor Function in Guillain Barre Syndrome
Status: COMPLETED
Conditions: Guillain-Barre Syndrome
Interventions: OTHER: Proprioceptive Neuromuscular Training|OTHER: Conventional Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monday-Focused Tailored Rapid Interactive Mobile Messaging for Weight Management 2
Status: COMPLETED
Conditions: Obesity|Weight Loss|mHealth|Healthy Diet
Interventions: BEHAVIORAL: Monday-Focused Tailored Rapid Interactive Mobile Messaging for Weight Management|BEHAVIORAL: Monday-Focused Written Messages for Weight Management|BEHAVIORAL: Educational Materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics Against Low Grade Inflammation and Increased Intestinal Permeability in the Elderly
Status: COMPLETED
Conditions: Low-grade Inflammation|Increased Intestinal Permeability
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Active, only probiotics|DIETARY_SUPPLEMENT: Active, blend of berries and probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pathophysiology and Prevention of Perioperative Myocardial Injury: A Prospective Randomized Controlled Trial
Status: UNKNOWN
Conditions: Coronary Artery Disease,
Interventions: DRUG: Ranolazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prevention of Caries in Head and Neck Cancer Survivors Who Underwent Radiotherapy
Status: RECRUITING
Conditions: Caries,Dental|Head and Neck Cancer|Radiotherapy; Complications
Interventions: OTHER: Application of CaP dental mousse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial in Healthy, HIV-1-Uninfected Adult Participants to Compare the Safety, Tolerability and Immunogenicity of CH505TF gp120 Produced From Stably Transfected Cells to CH505TF gp120 Produced From Transiently Transfected Cells
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: Stable CH505TF gp120|BIOLOGICAL: Transient CH505TF gp120|BIOLOGICAL: Glucopyranosyl Lipid Adjuvant-Stable Emulsion (GLA-SE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Observational Follow-up of Participants From Clinical Trial 64,185-202 (NCT00850993)
Status: COMPLETED
Conditions: Jaundice|Neonatal Hyperbilirubinemia
Interventions: DRUG: Stannsoporfin|DRUG: Placebo Control|OTHER: Phototherapy (as needed)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CBT Insomnia Teens: Augmenting SSRIs to Improve Youth Depression
Status: COMPLETED
Conditions: Insomnia|Depression
Interventions: BEHAVIORAL: CBT for Insomnia (CBT-I)|BEHAVIORAL: Sleep Hygiene (SH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Immune Response of an Investigational mRNA Vaccine for the Prevention of Respiratory Syncytial Virus and/or Human Metapneumovirus in Participants Aged 18 to 49 Years and 60 Years and Older
Status: ACTIVE_NOT_RECRUITING
Conditions: Respiratory Syncytial Virus Infection|Healthy Volunteers|Metapneumovirus Infection
Interventions: BIOLOGICAL: RSV/hMPV mRNA LNP 1|BIOLOGICAL: RSV/hMPV mRNA LNP 2|BIOLOGICAL: RSV mRNA LNP 1|BIOLOGICAL: hMPV mRNA LNP 1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: An Open-label Study of GSK1120212 Compared With Docetaxel in Stage IV KRAS-mutant Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer, Non-Small Cell
Interventions: DRUG: GSK1120212|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing Drug Sensitivity of Ovarian, Fallopian and Primary Peritoneal Adenocarcinomas
Status: COMPLETED
Conditions: Adenocarcinoma|Ovarian Neoplasms|Fallopian Tube Neoplasms|Peritoneal Neoplasms
Interventions: PROCEDURE: MiCK Assay
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Orange Juice Supplementation in Soccer Players
Status: COMPLETED
Conditions: Healthy Athletes
Interventions: DIETARY_SUPPLEMENT: Orange juice (1L/d)|DIETARY_SUPPLEMENT: Control drink (1L/d)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vitamin D Augmentation of Tekturna (Aliskiren) in Hypertension
Status: UNKNOWN
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Vitamin D (cholecalciferol)|DRUG: Tekturna(Aliskiren) plus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Recombinant Anti-tumor and Anti-virus Protein for Injection to Treat Advanced Neuroendocrine Tumors
Status: UNKNOWN
Conditions: Neuroendocrine Tumors
Interventions: DRUG: Recombinant anti-tumor and anti-virus protein for injection (Novaferon)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Skin-to-skin Contact on Placental Separation Time, Type, Postpartum Hemorrhage and Comfort
Status: COMPLETED
Conditions: Patient Comfort|Postpartum Hemorrhage|Midwifery|Placenta
Interventions: OTHER: skin-to-skin contact and delayed cord clamping|OTHER: avoiding skin-to-skin contact and early cord clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Building and Sustaining Interventions for Children: Task-sharing Mental Health Care in Low-resource Settings
Status: COMPLETED
Conditions: Grief|Post Traumatic Stress Disorder|Depression
Interventions: BEHAVIORAL: Trauma-Focused Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ex-Vivo Depletion of Myeloma Cells From Peripheral Blood Progenitor Cell Grafts
Status: WITHDRAWN
Conditions: Multiple Myeloma
Interventions: PROCEDURE: Apheresis|PROCEDURE: Stem Cell Transplantation|DRUG: Melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic and Pharmacokinetic Analysis of Oxymetazoline Absorption
Status: WITHDRAWN
Conditions: Dental Anesthesia|Nasal Surgical Procedures|Intranasal Drug Administration
Interventions: DRUG: Oxymetazoline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smart-phone Application Versus Conventional Paper for the Documentation of Voiding Dysfunction in Children
Status: NOT_YET_RECRUITING
Conditions: Voiding Dysfunction|Children
Interventions: DEVICE: Smart-phone Voiding Diary|DIAGNOSTIC_TEST: Paper voiding diary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Response of Haemodialysis Patients to BNT162b2 mRNA Cov-19 Vaccine
Status: COMPLETED
Conditions: COVID-19 Vaccines|Hemodialysis Complication
Interventions: BIOLOGICAL: Evaluation of the immunogenicity of the vaccine in haemodialysis patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Depakote (Divalproex Sodium) for Children With Temper Dysregulation and Severe Mood Swings
Status: COMPLETED
Conditions: Irritable Aggression
Interventions: DRUG: Divalproex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assess Feasibility of an Acellular Pertussis Vaccine (Pa) Given Soon After Birth, Followed by 3-dose Primary Vaccination With the DTPa-HBV-IPV/Hib Vaccine
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: DTPa-HBV-IPV/Hib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: 5-azacytidine Valproic Acid and ATRA in AML and High Risk MDS
Status: COMPLETED
Conditions: Acute Myelogenous Leukaemia (AML)|Myelodysplastic Syndrome (MDS)
Interventions: DRUG: 5 azacytidine - VALPROIC acid- Retinoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Survival Rate and Cost-effectiveness of Conventional vs ART Restorations in a School Setting
Status: NOT_YET_RECRUITING
Conditions: Dental Caries
Interventions: PROCEDURE: Atraumatic Restorative Treatment (ART)|PROCEDURE: Conventional Cavity Preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Retosiban (GSK221149) When Dosed With Efavirenz (EFZ)
Status: COMPLETED
Conditions: Obstetric Labour, Premature
Interventions: DRUG: Retosiban|DRUG: EFZ 600 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Post-Tonsillectomy Pain in Pediatric Patients
Status: COMPLETED
Conditions: Pain, Postoperative|Tonsillar Hypertrophy|Tonsillitis
Interventions: DRUG: Alternating Acetaminophen and Ibuprofen|DRUG: Combined Acetaminophen and Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
Status: SUSPENDED
Conditions: Clinical Stage III Cutaneous Melanoma AJCC v8|Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Clinical Stage IV Cutaneous Melanoma AJCC v8|Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Head and Neck Squamous Cell Carcinoma|Hypopharyngeal Squamous Cell Carcinoma|Laryngeal Squamous Cell Carcinoma|Lip and Oral Cavity Squamous Cell Carcinoma|Melanoma|Oropharyngeal Squamous Cell Carcinoma|Stage III Hypopharyngeal Carcinoma AJCC v8|Stage III Laryngeal Cancer AJCC v8|Stage III Lip and Oral Cavity Cancer AJCC v8|Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IV Hypopharyngeal Carcinoma AJCC v8|Stage IV Laryngeal Cancer AJCC v8|Stage IV Lip and Oral Cavity Cancer AJCC v8|Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Cabozantinib S-malate|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: DRUG: Cagrilintide|DRUG: Semaglutide|DRUG: Placebo cagrilintide|DRUG: Placebo semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bexagliflozin Efficacy and Safety Trial
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Bexagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Blood Pressure Reduction, Safety, and Tolerability of Canagliflozin in Patients With Hypertension and Type 2 Diabetes Mellitus on Stable Doses of Anti-hyperglycemic and Anti-hypertensive Agents
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Hypertension
Interventions: DRUG: Canagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Epinephrine in Irrigation Fluid for Visualization During Ankle Surgery
Status: NOT_YET_RECRUITING
Conditions: Intraoperative Bleeding
Interventions: DRUG: Epinephrine|PROCEDURE: Normal Saline irrigation fluid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Health Apps for Post-Pandemic Years for People With Physiological and Psychosocial Distress
Status: RECRUITING
Conditions: Physiological Stress|Psychological Distress|COVID-19 Stress Syndrome
Interventions: BEHAVIORAL: Physical Activity Training|OTHER: Mindfulness-based Intervention|OTHER: Energy Conservation Techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Insulin Glulisine Administered Pre-meal Versus Post-meal in Adult Subjects With Type 2 Diabetes Mellitus Receiving Insulin Glargine as Basal Insulin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: insulin glulisine|DRUG: insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Toolkit for Optimal Recovery After Orthopedic Injury
Status: COMPLETED
Conditions: Acute Orthopedic Injury
Interventions: BEHAVIORAL: Toolkit for Optimal Recovery after Orthopedic Injury|OTHER: Minimally Enhanced Usual Care (MEUC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fosrenol and Phosphorus Balance - Lanthanum Carbonate
Status: COMPLETED
Conditions: Chronic Kidney Failure|End-stage Renal Disease|Disorders Associated With Peritoneal Dialysis
Interventions: DRUG: lanthanum carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Laryngeal Preservation Comparing Induced CT Followed by RT vs CT Concomitant to RT
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Docetaxel|DRUG: Cisplatin|DRUG: Fluorouracil|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eylea to Treat Retinal Pigment Epithelial Detachment (RPED) Secondary to Wet Age-Related Macular Degeneration (wAMD)
Status: COMPLETED
Conditions: Retinal Pigment Epithelial Detachment Secondary to Age-related Macular Degeneration
Interventions: DRUG: Eylea
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypercortisolism and Epicardial Adipose Tissue
Status: COMPLETED
Conditions: Hypercortisolism
Interventions: BIOLOGICAL: Blood samples for measuring adiponectin, leptin and omentin plasma|DEVICE: MRI at 3 Tesla
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Predictors of Cognitive Outcomes in Geriatric Depression
Status: RECRUITING
Conditions: Major Depressive Disorder|Neuroticism|Cognitive Change|Stress
Interventions: DRUG: Sertraline, bupropion, desvenlafaxine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase 3 Study of YM060 in Patients With Diarrhea-predominant Irritable Bowel Syndrome (d-IBS)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: YM060
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Opening Wedge High Tibial Osteotomy
Status: TERMINATED
Conditions: Osteoarthrosis of Knee|Osteoarthritis, Knee
Interventions: PROCEDURE: HTO|OTHER: Supervised physiotherapeutic program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Intravitreal Bevacizumab in Pars Plana Vitrectomy for Vitreous Hemorrhage
Status: UNKNOWN
Conditions: Vitreous Hemorrhage Secondary to PDR
Interventions: DRUG: Bevacizumab|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acupuncture, Chinese Traditional Medicine, in Embryo Transfer
Status: COMPLETED
Conditions: Pregnancy
Interventions: OTHER: Bed Rest|PROCEDURE: Acupuncture|PROCEDURE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ASN-002 to Treat Basal Cell Carcinomas (BCCs) in Individuals With Basal Cell Nevus Syndrome (BCNS)
Status: SUSPENDED
Conditions: Basal Cell Carcinoma in Basal Cell Nevus Syndrome
Interventions: BIOLOGICAL: ASN-002
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Unified Cognitive-Behavioral Therapy (CBT) vs. Combined CBT and Dance/Movement Therapy (DMT) for Anxiety Disorders
Status: UNKNOWN
Conditions: Anxiety Disorders
Interventions: BEHAVIORAL: Unified Cognitive-Behavioral Therapy|BEHAVIORAL: Combined Cognitive-Behavioral and Dance/Movement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of Different Toothbrushes in Children
Status: RECRUITING
Conditions: Dental Plaque|Plaque, Dental|Oral Hygiene|Gingivitis|Periodontal Indexes
Interventions: DEVICE: standart manual toothbrush|DEVICE: 360 degree toothbrush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effectiveness of Electroacupuncture and Standard Therapy Compared to Standard Therapy in Gynecological Cancer Pain
Status: COMPLETED
Conditions: Gynecologic Cancer|Cancer Related Pain|Cancer Pain
Interventions: OTHER: Electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pilot Study of Preoperative Tarceva (Erlotinib) for Stages I/II Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-small Cell Lung
Interventions: DRUG: Tarceva (Erlotinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of GZR/EBR in Early Chronic Hepatitis C in HIV/HCV Co-infected Patients
Status: UNKNOWN
Conditions: Hepatitis C|HIV
Interventions: DRUG: Grazoprevir 100 mg/d 8 weeks|DRUG: Elbasvir 50 mg/d 8 weeks|DRUG: Grazoprevir 100 mg/d 12 weeks|DRUG: Elbasvir 50 mg/d 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Reactogenicity, and Immunogenicity Study of a Lyophilized COVID-19 mRNA Vaccine
Status: WITHDRAWN
Conditions: COVID-19 Pandemic
Interventions: BIOLOGICAL: A Lyophilized COVID-19 mRNA Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 99mTc/68Ga Labeled Anti-PD-L1 sdAb in Assessment of PD-L1 Expression in NSCLC
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: PROCEDURE: Injection of 99mTc-NM-01|PROCEDURE: Injection of 68Ga-NM-01
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Extragonadal Germ Cell Tumor|Ovarian Cancer|Testicular Germ Cell Tumor
Interventions: DRUG: ixabepilone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sample Collection Study to Evaluate DNA Markers in Subjects With Inflammatory Bowel Disease (IBD)
Status: COMPLETED
Conditions: Inflammatory Bowel Disease|Colorectal Neoplasms|Digestive System Diseases|Colonic Diseases|Colorectal Cancer
Interventions: DEVICE: Stool Collection Kit
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Home-based Exercise Intervention for Patients With Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Castration-resistant Prostate Cancer|Androgen Deprivation Therapy
Interventions: BEHAVIORAL: Home-based exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Advanced Non-Small Cell Lung Cancer|Squamous Cell Carcinoma|Advanced NSCLC|Adenosquamous Carcinoma|Adenocarcinoma
Interventions: DRUG: Aldesleukin|DRUG: Fludarabine|DRUG: Cyclophosphamide|BIOLOGICAL: Young TIL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Permanency in Children and Families
Status: COMPLETED
Conditions: Substance Abuse|Substance Use|Child Abuse|Neglect, Child
Interventions: BEHAVIORAL: Peer Recovery Support|BEHAVIORAL: Family Treatment Drug Court with Medications for Opioid Use Disorders (MOUD)|BEHAVIORAL: Relational Skill Building based on the Nurturing Parenting Program (NPP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT