pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Aurora Kinase Inhibitor LY3295668 in Combination With Osimertinib for the Treatment of Advanced or Metastatic EGFR-Mutant Non-squamous Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lung Non-Squamous Non-Small Cell Carcinoma|Metastatic Lung Non-Squamous Non-Small Cell Carcinoma|Stage III Lung Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|Stage IIIC Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: DRUG: Aurora A Kinase Inhibitor LY3295668|DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of Polyene Phosphatidylcholine Injection (AYP-101) for the Reduction of Submental Fat
Status: COMPLETED
Conditions: Moderate or Severe Submental Fullness
Interventions: DRUG: Polyene phosphatidylcholine injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Decision Support for Medication Management and Adherence
Status: COMPLETED
Conditions: Hypertension|Diabetes Mellitus|Stroke|Myocardial Ischemia|Heart Failure|Asthma
Interventions: OTHER: Medication Management report|OTHER: Care manager email notices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Intratumoral Selicrelumab With Atezolizumab in Patients With Refractory or Relapsed B Cell Lymphoma
Status: TERMINATED
Conditions: Recurrent B-Cell Non-Hodgkin Lymphoma|Refractory B-Cell Non-Hodgkin Lymphoma
Interventions: DRUG: Selicrelumab|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Zinc on Concurrent Chemo-radiotherapy Induced Taste Alterations
Status: COMPLETED
Conditions: Taste, Altered
Interventions: DRUG: Placebo oral Zinc capsule|DRUG: Zinc Sulfate 220 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Different Targeted Antibody-drug Conjugates For HER2 Ultra-low or No Expression Advanced Breast Cancer（GALAXY）
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: SHR-A1811|DRUG: TROP2 ADC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerance Study of the Silicone Bands on Medical Compression Stockings
Status: TERMINATED
Conditions: Skin Lesions
Interventions: DEVICE: Innothera's brand Stockings|OTHER: Stockings other than Innothera's brand
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cytokine-induced Memory-like NK Cells in Combination With Chemotherapy in Pediatric Patents With Refractory or Relapsed AML
Status: WITHDRAWN
Conditions: Refractory Acute Myeloid Leukemia|Relapsed Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Cytokine induced memory-like NK cells|DRUG: Fludarabine|DRUG: Ara-C|DRUG: G-CSF|DRUG: Interleukin-2|PROCEDURE: Leukapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiological Responses to Maximal 4-s Sprint Interval Cycling
Status: COMPLETED
Conditions: Exercise, Cardiovascular Function, Fatigue, Muscular Power
Interventions: OTHER: inertial-load exercise (ILE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Chemotherapy Plus PSC 833 Followed by Interleukin-2 in Treating Patients With Acute Myelogenous Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: ara-C|DRUG: Daunorubicin|DRUG: Etoposide|DRUG: PSC-833|BIOLOGICAL: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Will the Use of Osteopathic Manipulative Treatments Help Alleviate Headache Pain
Status: UNKNOWN
Conditions: Headache
Interventions: PROCEDURE: Osteopathic Manipulative Treatment|PROCEDURE: Sham Osteopathic Manipulative Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Fecal Transplantation in Patients Colonic Diverticulitis
Status: NOT_YET_RECRUITING
Conditions: Diverticulitis, Colonic|Colon Inflamed
Interventions: OTHER: Fecal Microbiome|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Markers of Severity (CD177,S100A8 &S100A12) in Sever Acute Respiratory Syndrome Coronavirus 2(SARS-COV-2) Patients
Status: UNKNOWN
Conditions: COVID-19
Interventions: DIAGNOSTIC_TEST: real time PCR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate Safety/Duration in Stomach of Extended Release Capsules Containing Memantine Hydrochloride in Healthy Adults
Status: COMPLETED
Conditions: Alzheimer Disease|Gastric Retention|Healthy
Interventions: DRUG: LYN-057|PROCEDURE: Imaging Assessment (MRI)|PROCEDURE: Imaging Assessment (U/S)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subacromial Injection of Epinephrine Improves Visualization in Shoulder Arthroscopy
Status: COMPLETED
Conditions: Shoulder Arthroscopy
Interventions: DRUG: Bupivacaine with Epinephrine|DRUG: Bupivacaine alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of ONTAK in Previously Treated Patients With Low-grade Non-Hodgkin's Lymphoma (NHL)
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma|Lymphoma, B-cell|Lymphoma, Low-grade
Interventions: DRUG: ONTAK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Carboplatin, Abraxane, Avastin as Neoadjuvant Therapy for Her2-Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Abraxane|DRUG: Carboplatin|DRUG: Avastin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Rehabilitation in Improving Lung Function in Patients With Locally Advanced Non-Small Cell Lung Cancer Undergoing Chemoradiation
Status: WITHDRAWN
Conditions: Cachexia|Fatigue|Pulmonary Complications|Radiation Toxicity|Recurrent Non-small Cell Lung Cancer|Stage IIIA Non-small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: BEHAVIORAL: exercise intervention|PROCEDURE: pulmonary complications management/prevention|PROCEDURE: quality-of-life assessment|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Safety of Foradil in Patients With Persistent Asthma
Status: TERMINATED
Conditions: Persistent Asthma
Interventions: DRUG: Formoterol 12 mcg|DRUG: Fluticasone propionate 100 mcg|DRUG: Fluticasone propionate 250 mcg|DRUG: Fluticasone propionate 500 mcg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety Following Injection of GP0045 Compared to Restylane Lyft Lidocaine
Status: COMPLETED
Conditions: Safety
Interventions: DEVICE: GP0045|DEVICE: Restylane Lyft Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: CARINAE for Stress Relief in Perioperative Care
Status: COMPLETED
Conditions: Psychological Stress|Cardiopulmonary Bypass Surgery|Coronary Artery Bypass Surgery|Cardiac Valve Replacement|Hip Replacement|Orthognathic Surgery|Scoliosis|Knee Replacement|Prostate Cancer|Kidney Cancer|Bladder Cancer
Interventions: DEVICE: SaMD CARINAE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre- and Post-neuromusculoskeletal Injury Risk Evaluation for Return-to-Duty Enhancement
Status: RECRUITING
Conditions: Musculoskeletal Injuries
Interventions: OTHER: PREPARE Initial Clinical Assessment - Pilot (two iterations)|OTHER: PREPARE Initial Clinical Assessment - Pre-Injury (one iteration)|OTHER: PREPARE Initial Clinical Assessment - Post-Injury (up to three iterations)|OTHER: PREPARE Optimized Clinical Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Feasible Smart Upper Limb Rehabilitation Model for Patients With Stroke and Spinal Cord Injuries
Status: RECRUITING
Conditions: Stroke|Spinal Cord Injuries
Interventions: OTHER: Robot-assisted therapy|OTHER: Task-oriented training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: XL119 Versus 5-Fluorouracil (5-FU) Plus Leucovorin (LV) in Subjects With Advanced Biliary Tumors
Status: TERMINATED
Conditions: Biliary Tract Cancer
Interventions: DRUG: becatecarin|DRUG: 5-Fluorouracil Plus Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Tilapia Skin for Palate Repair and Protection After Graft Removal
Status: UNKNOWN
Conditions: Pain, Postoperative|Palate; Wound|Cicatrization
Interventions: DEVICE: Tilapia skin|DEVICE: Surgical Wound Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Psychotherapy for Young Adults With Mild-to-moderate Depression: Does Virtual Reality Increase Its Efficacy
Status: ACTIVE_NOT_RECRUITING
Conditions: Depression
Interventions: BEHAVIORAL: Cognitive-behavioral therapy|BEHAVIORAL: Personal Construct Therapy|BEHAVIORAL: Personal Construct Therapy with virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: dacarbazine|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: melphalan|DRUG: tretinoin|DRUG: vincristine sulfate|DRUG: vindesine|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: conventional surgery|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Mineral Water Rich in Magnesium and Perceived Stress in Healthy Consumers
Status: COMPLETED
Conditions: Magnesium Deficiency|Stress, Psychological
Interventions: OTHER: Mg(+)|OTHER: Mg(-)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About the Safety of BAY3283142 in People With Mild to Moderate High Blood Pressure
Status: RECRUITING
Conditions: Chronic Kidney Disease|Non-proliferative Diabetic Retinopathy|Arterial Hypertension
Interventions: DRUG: BAY3283142|DRUG: Placebo to BAY3283142
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesia With Local Infiltration After Femoral Neck Fracture
Status: COMPLETED
Conditions: Femoral Neck Fracture
Interventions: DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Association of Perceived Occupational Performance and Satisfaction, Balance, Gait, and Fear of Falling in Older Adult With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Gait|Balance|Occupational Problems
Interventions: OTHER: Canadian Occupational Performance Measure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Flaxseed Consumption, Alone and in Combination With the Mediterranean-like Diet, on Some Indicators Related to Atherosclerosis
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: OTHER: Flaxseed|OTHER: the Mediterranean-like diet|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Medication Following Bariatric Surgery for Type 2 Diabetes Mellitus
Status: RECRUITING
Conditions: Obesity|Type 2 Diabetes
Interventions: PROCEDURE: Bariatric surgery + goal directed medical therapy|PROCEDURE: Bariatric surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Prescriptive Treatment of the Hips Improve Outcomes in Patients With Low Back Pain? A Randomized Controlled Trial
Status: COMPLETED
Conditions: Low Back Pain
Interventions: PROCEDURE: Prescriptive Hip Exercises and Manual Therapy techniques|PROCEDURE: Pragmatic low back pain treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Theramine on Chronic Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: Active Theramine and Active Naproxen|OTHER: Theramine and naproxen-like placebo|DRUG: Naproxen and Theramine-like placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-inferiority Clinical Trial of Dexchlorpheniramine (Cream Versus Gel) in the Relief of Sunburn Related Symptoms
Status: UNKNOWN
Conditions: Sunburn
Interventions: DRUG: Dexchlorpheniramine 1% gel|DRUG: Dexchlorpheniramine 1% cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dutch Acute HCV in HIV Study (DAHHS-2): Grazoprevir/Elbasvir for Acute HCV
Status: COMPLETED
Conditions: Acute Hepatitis C|Human Immunodeficiency Virus|Hepatitis C
Interventions: DRUG: Grazoprevir/Elbasvir 100mg/50mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [Tc-99m]-RPI-087 as an Imaging Marker in Osteoarthritis of the Knee Compared to Healthy Volunteers
Status: UNKNOWN
Conditions: Healthy|Osteo Arthritis Knee
Interventions: DRUG: [Tc-99m]-RPI-T-087 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: MEN1309 I.v. Infusion in Pts With CD205-positive Metastatic Solid Tumors and Relapsed or Refractory NHL Ph I Study
Status: TERMINATED
Conditions: Metastatic Solid Tumors|Relapsed/Refractory Non-Hodgkin Lymphoma
Interventions: DRUG: MEN1309
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraosseous Infusion of Unrelated Cord Blood Grafts
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Chronic Myelogenous Leukemia|Myelodysplastic Syndrome
Interventions: PROCEDURE: cord blood infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation Study of a cOmputer Pharmacokinetic Tool to assIst in the Follow up Care of haeMophilia A Patients
Status: COMPLETED
Conditions: Haemophilia A
Interventions: DRUG: Recombinant Factor VIII (Kogenate FS, BAY14-2222)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Evaluating the Efficacy of Allogeneic Transplant Conditioning With Adaptive Dose Busulfan Intravenous (Busilvex®) in Patients at High Risk of Carrying Blood Diseases
Status: COMPLETED
Conditions: Hematological Diseases
Interventions: DRUG: Allogeneic transplant conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Adult B Acute Lymphoblastic Leukemia|Childhood B Acute Lymphoblastic Leukemia
Interventions: DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Daunorubicin Hydrochloride|DRUG: Dexamethasone|DRUG: Doxorubicin Hydrochloride|DRUG: Leucovorin Calcium|DRUG: Mercaptopurine|DRUG: Methotrexate|DRUG: Pegaspargase|DRUG: Prednisone|RADIATION: Radiation Therapy|DRUG: Thioguanine|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Seating System for Scoliosis in Non-ambulatory Children With Cerebral Palsy: A Pilot Randomized Controlled Trial
Status: COMPLETED
Conditions: Cerebral Palsy|Neuromuscular Scoliosis
Interventions: DEVICE: a modular adaptive seating system|OTHER: home exercise program for scoliosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of Different Dosing Schedules of Trivalent Influenza Vaccine in HIV-infected Pregnant Women
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Trivalent influenza vaccine (seasonal)|BIOLOGICAL: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Influence of Mechanical Ventilation Mode on Arterial Pressure Variations- a Pilot Study
Status: WITHDRAWN
Conditions: Blood Pressure|Critical Illness|Hypovolemia
Interventions: OTHER: Ventilator mode change|DEVICE: Monitoring of blood pressure variation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Ixekizumab Diabetes Intervention Trial (I-DIT)
Status: RECRUITING
Conditions: Type1 Diabetes Mellitus
Interventions: DRUG: Ixekizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quit Smoking Study for People Who Use E-Cigarettes
Status: ACTIVE_NOT_RECRUITING
Conditions: Nicotine Addiction|E-Cig Use|Quitting Smoking
Interventions: DRUG: Nicotine replacement therapy patch|DRUG: Nicotine replacement therapy lozenge|BEHAVIORAL: Quit electronic cigarettes|BEHAVIORAL: Continue electronic cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Nerve Blocks for Episodic Migraine
Status: RECRUITING
Conditions: Episodic Migraine
Interventions: DRUG: Bupivacaine HCl 0.5% Injectable Solution|DRUG: Methylprednisolone 40 MG Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Assessment of PFT, Safety, and PK of Zileuton Injection in Asthma Patients
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: zileuton|DRUG: placebo|DRUG: zileuton
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erythema at Exit Site & Tablet Camera
Status: COMPLETED
Conditions: CLABSI - Central Line Associated Bloodstream Infection|CRBSI - Catheter Related Bloodstream Infection|Digital Technology
Interventions: OTHER: Set of Photos
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of a Tiotropium Inhaler For Shortness of Breath in Advanced Non-Small Cell Lung Cancer
Status: UNKNOWN
Conditions: NSCLC|Dyspnea
Interventions: DRUG: Tiotropium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Defactinib, Avutometinib and Nivolumab for the Treatment of Anti-PD1 Refractory LKB1-Mutant Advanced Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Advanced Lung Adenocarcinoma|Refractory Lung Adenocarcinoma|Stage III Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8
Interventions: DRUG: Avutometinib|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Defactinib|BIOLOGICAL: Nivolumab|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Overnight Switch Trial From Pramipexole IR to Pramipexole ER in Patients With Early Parkinson Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Pramipexole Extended Release|DRUG: Pramipexole Immediate Release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Treatment of Resistant Hypertension and Atrial Fibrillation
Status: COMPLETED
Conditions: Hypertension, Resistant to Conventional Therapy|Atrial Fibrillation
Interventions: PROCEDURE: Circumferential PV isolation|PROCEDURE: Circumferential PVI+renal denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmaco-metabolomic Effects of Statins: METASTATINE
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DRUG: Atorvastatin 40mg Tablet|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Balanced Nutrition Meal Replacement Along With a Caloric Restriction on Body Weight Control
Status: COMPLETED
Conditions: Obesity|Diet Modification|Nutrient; Excess
Interventions: DIETARY_SUPPLEMENT: Meal replacement diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardio Renal Effects of SGLT2 Inhibitors Among Lupus Nephritis Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: SLE|Lupus Nephritis|SGLT2 Inhibitors
Interventions: DRUG: dapagliflozin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Reinforcing Effects of Cocaine During Phendimetrazine Maintenance
Status: COMPLETED
Conditions: Cocaine Use Disorder
Interventions: DRUG: Phendimetrazine|DRUG: Cocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: EFFECT OF HIGH INTENSITY LASER IN PATELLOFEMORAL PAIN SYNDROME
Status: UNKNOWN
Conditions: Physical Therapy|Orthopedic Disorder
Interventions: OTHER: High Intensity Laser Therapy Group|OTHER: Ultrasound and Transcutaneous Electrical Nerve Stimulation Group|OTHER: Ultrasound and Interferential Current Stimulation Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pro-rEsolving and pRo-inflammatory reSPonses to Acute exhaustIve exeRcisE in Healthy Individuals
Status: RECRUITING
Conditions: Exercise
Interventions: BEHAVIORAL: Graded-Intensity Treadmill Exercise Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Rituximab in Renal Allograft Recipients Who Develop Early De Novo Anti-HLA Alloantibodies
Status: COMPLETED
Conditions: Kidney Transplant|Kidney Transplant Recipient|Graft Function/Survival|de Novo HLA Antibodies Development
Interventions: DRUG: Rituximab plus immunosuppression|DRUG: Placebo plus immunosuppression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low vs Standard Pneumoperitoneum Pressure During Single Port Access Laparoscopic for Adnexal Pathology
Status: UNKNOWN
Conditions: Adnexal Benign Pathology
Interventions: PROCEDURE: Low pression pneumoperitoneum|PROCEDURE: Standard Pression Pneumoperitoneum|PROCEDURE: Single Port Access Laparoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ivosidenib Plus Durvalumab and Gemcitabine/Cisplatin as First-Line Therapy in Participants With Locally Advanced or Metastatic Cholangiocarcinoma With an IDH1 Mutation
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced, Unresectable or Metastatic Cholangiocarcinoma With an IDH1 Mutation
Interventions: DRUG: Ivosidenib|DRUG: Durvalumab (for the first 8, 21-day, cycles)|DRUG: Gemcitabine (for the first 8, 21-day, cycles)|DRUG: Cisplatin (for the first 8, 21-day, cycles)|DRUG: Durvalumab (starting from cycle 9)|DRUG: Ivosidenib Recommended Combination Dose (RCD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estradiol and Progesterone Levels Following Frozen Embryo Transfer
Status: ACTIVE_NOT_RECRUITING
Conditions: Infertility
Interventions: DRUG: Estradiol Tablets|DRUG: Progesterone|DRUG: Follitropin Alfa|DRUG: Chorionic Gonadotropin, Alpha
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure
Status: COMPLETED
Conditions: Acute Liver Failure|Hepatic Encephalopathy
Interventions: DRUG: N-acetylcysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Efficacy of Obinutuzumab and Bendamustine Treatment in Participants With Refractory or Relapsed Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: bendamustine|DRUG: obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Neurostimulation to Accelerate Change in Misophonia: a Pilot Study
Status: RECRUITING
Conditions: Misophonia|Emotion Dysregulation|Sensory Processing Disorder|Auditory Over Responsivity|Anxiety Disorder|Sound Sensitivity
Interventions: DEVICE: High Frequency Repetitive Transcranial Magnetic Stimulation (HF rTMS)|DEVICE: Sham Repetitive Transcranial Magnetic Stimulation (sham- rTMS)|BEHAVIORAL: Cognitive Restructuring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prostate Resection After Microwave Ablation (PRAMA)
Status: RECRUITING
Conditions: Prostate Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|DEVICE: Microwave Ablation|DEVICE: Multiparametric Magnetic Resonance Imaging|OTHER: Questionnaire Administration|PROCEDURE: Radical Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incidence of Acute Kidney Injury and Risk Factors in Newborns With Congenital Diaphragmatic Hernia
Status: RECRUITING
Conditions: Congenital Diaphragmatic Hernia|Acute Kidney Injury|Multiple Organ Failure|Pulmonary Hypertension|Hyperchloremia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open Label Extension Study Evaluating Safety and Tolerability of AAB-003 (PF-05236812) in Subject With Mild to Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: AAB-003 (PF-05236812)|DRUG: AAB-003 (PF-05236812)|DRUG: AAB-003 (PF-05236812)|DRUG: AAB-003 (PF-05236812)|DRUG: AAB-003 (PF-05236812)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial on the Effectiveness of TUMT Compared to PAE in Reducing Severe LUTS in Men With BPH
Status: RECRUITING
Conditions: Prostatic Hyperplasia|Lower Urinary Tract Symptoms
Interventions: PROCEDURE: Transurethral Microwave Thermotherapy|PROCEDURE: Prostate Artery Embolisation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Mechanistic Randomized Controlled Trial on the Cardiovascular Effect of Berberine
Status: COMPLETED
Conditions: Cardiovascular Risk Factor
Interventions: DRUG: Berberine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Cord Blood Plus Vitamin D and Omega 3s in T1D
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: BIOLOGICAL: Autologous UCB|DIETARY_SUPPLEMENT: Omega 3 FA|DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study to Evaluate the Efficacy and Safety of Metoclopramide Nasal Spray in Women With Diabetic Gastroparesis
Status: COMPLETED
Conditions: Diabetic Gastroparesis
Interventions: DRUG: Metoclopramide Nasal Spray|DRUG: Placebo Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Iloprost on Capillary Recruitment and Insulin Sensitivity in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Insulin Sensitivity/Resistance
Interventions: DRUG: Iloprost infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hatha Yoga in Improving Physical Activity, Inflammation, Fatigue, and Distress in Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer|Depression|Fatigue|Pain
Interventions: PROCEDURE: Yoga Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Treatment of High Intensity Transcranial Current Stimulation for Alzheimer's Disease
Status: NOT_YET_RECRUITING
Conditions: Alzheimer's Disease|Mild Cognitive Impairment|Dementia
Interventions: DEVICE: Transcranial alternating current stimulation(real stimulation)|DEVICE: Transcranial alternating current stimulation(sham stimulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Simulines Non-Inferiority Pivotal Study
Status: TERMINATED
Conditions: Skin Laxity
Interventions: DEVICE: Ulthera System with standard transducer|DEVICE: Ulthera System with prototype 2 simulines transducer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Insulin Detemir on Use of Energy in Type 1 Diabetes
Status: TERMINATED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin detemir|DRUG: insulin NPH|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modulating Neuropathic Pain With Transcranial Direct Current Stimulation
Status: TERMINATED
Conditions: Pain, Neuropathic|Complex Regional Pain Syndromes|Phantom Limb Pain|Spinal Cord Injuries
Interventions: DEVICE: transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Different Sequences of Cilta-cel, Talquetamab in Combination With Daratumumab and Teclistamab in Combination With Daratumumab Following Induction With Daratumumab, Bortezomib, Lenalidomide and Dexamethasone in Participants With Standard-risk Newly Diagnosed Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Cilta-cel|DRUG: Talquetamab|DRUG: Daratumumab|DRUG: Teclistamab|DRUG: Bortezomib|DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Choline Fenofibrate and Carotid Atherosclerosis in Patients With Type 2 Diabetes and Combined Dyslipidemia
Status: RECRUITING
Conditions: Dyslipidemia|Atherosclerosis|Diabetes Mellitus, Type 2
Interventions: DRUG: Choline fenofibrate|DRUG: Policosanol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Radium-223 Dichloride (Xofigo), a Treatment That Gives Off Radiation That Helps Kill Cancer Cells, Compared to a Treatment That Inactivates Hormones (New Antihormonal Therapy, NAH) in Patients With Prostate Cancer That Has Spread to the Bone Getting Worse on or After Earlier NAH
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Castrate Resistant Prostate Cancer (mCRPC)
Interventions: DRUG: Radium-223 dichloride (Xofigo, BAY88-8223)|DRUG: NAH therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of APRV and LTV on Lung Ventilation and Perfusion in Patients With Moderate-to-severe ARDS
Status: RECRUITING
Conditions: Acute Respiratory Distress Syndrome
Interventions: DEVICE: APRV|DEVICE: LTV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Menthol and Mint Experimental Tobacco Marketplace (ETM) Study
Status: COMPLETED
Conditions: Cigarette Smoking|Vaping
Interventions: BEHAVIORAL: Tobacco e-liquids|BEHAVIORAL: Menthol and Tobacco e-liquids|BEHAVIORAL: Mint, Menthol and Tobacco e-liquids|BEHAVIORAL: All e-liquid flavors
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Long Term Follow-up Study of Safety and Efficacy of Botulinum Toxin Type A for the Treatment of Patients With Idiopathic Overactive Bladder With Urinary Incontinence
Status: COMPLETED
Conditions: Overactive Bladder|Urinary Incontinence
Interventions: BIOLOGICAL: botulinum toxin Type A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Point-of-care Assessment of Thrombin Generation and Platelet Function in Children Requiring Cardiopulmonary Bypass
Status: UNKNOWN
Conditions: Platelet Function Tests|Thrombin Generation Tests|Perioperative Coagulopathy
Interventions: DEVICE: Thrombin generation and Platelet Function Testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Selective Inhibitor of Nuclear Export (SINE) Selinexor (KPT-330) in Patients With Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: selinexor (KPT-330)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Denervation in Patients With Resistant Hypertension and Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Hypertension|Obstructive Sleep Apnea
Interventions: DEVICE: Renal denervation with a catheter-based procedure (Symplicity® Catheter System)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of Ublituximab in Combination With Umbralisib and Venetoclax Compared to Ublituximab in Combination With Umbralisib in Subjects With CLL (ULTRA-V)
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Ublituximab|DRUG: Umbralisib|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Exercise for Patients Undergoing Complex Cancer Surgery
Status: UNKNOWN
Conditions: Postoperative Complications|Physical Activity|Surgery--Complications
Interventions: OTHER: Control|OTHER: Exercise - HIIT Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: COVID-19 Prevention and Treatment in Cancer; a Sequential Multiple Assignment Randomised Trial;
Status: COMPLETED
Conditions: Cancer|Covid19|Respiratory Viral Infection
Interventions: DRUG: Interferon alfa|DRUG: Selinexor|DRUG: Lenzilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a New EUS-guided Needle (ProCore) Comparing to EUS-TCB Needle (Quick-Core)
Status: COMPLETED
Conditions: GIST
Interventions: DEVICE: EUS-TCB needle (QuickCore) standard of care|DEVICE: EUS-Guided biopsy needle (ProCore)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy Of Trimrox On Body Recomposition And Weight Management (TRCAP21)
Status: UNKNOWN
Conditions: Body Weight Changes
Interventions: DIETARY_SUPPLEMENT: Anthropometric Measurement of the Chest, Upper Arm/Bicep, Hips, Thighs and Waist/ Belly in Inches|DIETARY_SUPPLEMENT: Oxygen Saturation|DIETARY_SUPPLEMENT: Total Blood Chemistry|DIETARY_SUPPLEMENT: Adverse Event Monitoring|DIETARY_SUPPLEMENT: Body Weight Monitoring|DIETARY_SUPPLEMENT: Physical well-being including mood, energy, satiety level. sugar cravings, sleep, and overall health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Retrospective Multi-Center Study to Compare Perioperative Outcomes for Robotic-assisted Lobectomy With Those Associated With VATS and Open Lobectomy for Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: PROCEDURE: Robotic-assisted lobectomy using da Vinci Surgical System|PROCEDURE: VATS (video assisted thoracic surgery)|PROCEDURE: Open lobectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: AMG 386, 20060159 Phase 2, RCC 1st Line in Combination With Sorafenib
Status: COMPLETED
Conditions: Advanced Renal Cell Carcinoma
Interventions: DRUG: AMG 386|DRUG: Sorafenib|DRUG: AMG 386 placebo IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Psychoeducational Videos and Digital Assessments for BPD
Status: RECRUITING
Conditions: Borderline Personality Disorder
Interventions: OTHER: Psychoeducational Videos|OTHER: Neuropsychological Feedback|OTHER: Non-BPD-related Educational Videos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study With Allergen Extracts of House Dust Mites for Specific Sublingual Immunotherapy
Status: UNKNOWN
Conditions: Allergic Rhinitis
Interventions: BIOLOGICAL: Allergen extract|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Potential of Florbetapir F 18 PET to Inform Clinical Diagnosis and Management of Patients With Progressive Cognitive Decline
Status: COMPLETED
Conditions: Progressive Cognitive Decline
Interventions: DRUG: florbetapir F 18
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pragmatic Randomised Study to Optimise Screening, Prevention and Care for Tuberculosis in Malawi
Status: UNKNOWN
Conditions: Tuberculosis|Hiv|Tuberculosis, Pulmonary
Interventions: OTHER: Optimised HIV screening and linkage to care|OTHER: Optimised tuberculosis screening and linkage to care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Aspirin as an Ultraviolet (UV) Protectant in Human Subjects at Risk for Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: DRUG: Aspirin 81 mg|DRUG: Aspirin 325mg|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Ph 1 Trial of ADI-PEG 20 Plus Docetaxel in Solid Tumors With Emphasis on Prostate Cancer and Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Solid Tumors|Prostate Cancer
Interventions: DRUG: ADI-PEG 20
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Inhaled Carbon Monoxide to Treat Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Respiratory Distress Syndrome|Sepsis
Interventions: DRUG: Inhaled Carbon Monoxide at CFK equation-determined personalized dose (200-500 ppm to achieve a COHb level of 6-8%)|OTHER: Inhaled Medical air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: First in Man Trial of BI 113608
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 113608|DRUG: BI 113608|DRUG: BI 113608|DRUG: BI 113608|DRUG: Placebo|DRUG: BI 113608|DRUG: BI 113608|DRUG: BI 113608|DRUG: BI 113608|DRUG: BI 113608|DRUG: BI 113608
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Remote Observed Dosing of Suboxone to Improve Clinical Practice
Status: COMPLETED
Conditions: Opioid-use Disorder|Opioid Dependence|Opiate Dependence
Interventions: BEHAVIORAL: Suboxone Remote Observed Dosing|OTHER: Suboxone Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Steroid Therapy in Acute Bronchiolitis A New Old Line of Therapy.
Status: UNKNOWN
Conditions: Bronchiolitis; Respiratory Syncytial Virus
Interventions: DRUG: Dexamethasone orally.|DRUG: Dexamethasone parenteral.|DRUG: Inhaled nebulized Budesonide.|DRUG: Inhaled nebulized salbutamol.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radioprotective Effect of Chinese Herbal Medicine on Oral Mucositis
Status: UNKNOWN
Conditions: Head and Neck Cancer|Oral Mucositis
Interventions: DRUG: Zi-Yin-Liang-Ge-San
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Reduce Sedentariness and Enhance Psychological Well-being of Office Workers With TCM-based Intervention
Status: NOT_YET_RECRUITING
Conditions: Sedentary Behavior
Interventions: BEHAVIORAL: Traditional Chinese Medicine-based program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LDX and Functional Magnetic Resonance Imaging (fMRI in Menopausal Women
Status: COMPLETED
Conditions: Menopause|Brain Activity|Cognition
Interventions: DRUG: Lisdexamfetamine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Daily Regimen of Tenofovir/Emtricitabine as Prevention for COVID-19 in Health Care Personnel in Colombia
Status: UNKNOWN
Conditions: Severe Acute Respiratory Syndrome Coronavirus 2|COVID-19
Interventions: DRUG: Tenofovir/ Emtricitabine ( 300 mg / 200 mg daily during 60 days) + Personal Protective Equipment (PPE)|OTHER: Placebo (1 tablet daily during 60 days) + Personal Protective Equipment (PPE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION