pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparing Nano Hybrid Composite Blocks With Ceramic Blocks in Indirect Restorations 2. Protocol Registration:
Status: UNKNOWN
Conditions: the Clinical Performance of Indirect Restoration Fabricated From Nanohybrid Cad Cam Composite Blocks and Ceramic Blocks
Interventions: OTHER: grandio blocks|OTHER: emax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics Study of Oral IXAZOMIB in Participants With Advanced Nonhematologic Malignancies or Lymphoma
Status: COMPLETED
Conditions: Nonhematologic Malignancies|Lymphoma
Interventions: DRUG: Ixazomib 2.5 mg|DRUG: Ixazomib 4 mg Capsule A|DRUG: Ixazomib 4 mg Capsule B|DRUG: Ketoconazole|DRUG: Rifampin|DRUG: Clarithromycin|DRUG: Ixazomib 4 mg Capsule B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tenecteplase for Restoration of Function in Dysfunctional Central Venous Catheters
Status: COMPLETED
Conditions: Dysfunctional Central Venous Access Catheters
Interventions: DRUG: placebo|DRUG: tenecteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Safe Drinking Water in Treatment of Severe Acute Malnutrition (Pakistan)
Status: UNKNOWN
Conditions: Marasmus
Interventions: OTHER: Point of Use (PoU) water treatment flocculent disinfectant.|OTHER: Point of Use (PoU) water treatment chlorine disinfectant|DEVICE: Point of Use (PoU) ceramic water filter|OTHER: Standard Severe Acute Malnutrition Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Urological and Renal Disease Engaging Adolescents in Adherence Collaborative Trial
Status: COMPLETED
Conditions: Spina Bifida|Kidney Transplant
Interventions: BEHAVIORAL: Behavioral Feedback and Economic Incentives: Arm 1|BEHAVIORAL: Behavioral Feedback and Economic Incentives: Arm 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Buffered Numbing Solution on Patients With Toothaches
Status: COMPLETED
Conditions: Irreversible Pulpitis (Toothache)
Interventions: DRUG: buffered lidocaine|DRUG: nonbuffered lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Value of Systematic Biopsies During Vertebroplasty for the Treatment of Osteoporotic Vertebral Fractures
Status: COMPLETED
Conditions: Vertebral Compression Fracture|Myeloma|Bone Metastases|Malignant Bone Tumour|Lymphoma|Plasmocytoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of GS-4774 in Combination With Tenofovir Disoproxil Fumarate (TDF) for the Treatment of Participants With Chronic Hepatitis B (CHB) and Who Are Currently Not on Treatment
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Tenofovir disoproxil fumarate|BIOLOGICAL: GS-4774
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azithromycin Plus Chloroquine Versus Mefloquine for the Treatment of Uncomplicated Malaria in Africa
Status: COMPLETED
Conditions: Malaria, Falciparum
Interventions: DRUG: Azithromycin/Chloroquine|DRUG: Mefloquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Autologous Bone Marrow Stem Cells in Pressure Ulcer Treatment
Status: COMPLETED
Conditions: Type IV Pressure Ulcers|Chronic Wounds|Spinal Cord Injury
Interventions: PROCEDURE: Infusion of autologous bone marrow stem cells after wound debridement.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial of Economic Incentives to Promote Walking Among Full Time Employees
Status: COMPLETED
Conditions: Physical Activity
Interventions: DEVICE: Fitbit|BEHAVIORAL: Cash Incentives|BEHAVIORAL: Charitable Incentives|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose:
Clinical trial: Bioequivalence Study of PF-06651600 Capsules Relative to Tablets and Estimation of Food Effect on Capsules.
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: PF-06651600
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Telotristat Ethyl for Reducing Intraoperative Carcinoid Crisis in Patients With Neuroendocrine Tumors
Status: WITHDRAWN
Conditions: Neuroendocrine Tumors
Interventions: DRUG: Telotristat Ethyl Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability and Efficacy Study in Chronic Obstructive Pulmonary Disease (COPD) Patients With QBM076.
Status: TERMINATED
Conditions: COPD
Interventions: DRUG: QBM076|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cyclophosphamide in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Fanconi's Anemia
Status: COMPLETED
Conditions: Fanconi Anemia
Interventions: DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: methotrexate|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: nonmyeloablative allogeneic hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Proof the Clinical and Bacteriological Non-inferiority of Ampicillin/Amoxicillin Versus Moxifloxacin in Hospitalized Patients With Non-severe Community-acquired Pneumonia
Status: TERMINATED
Conditions: Community Acquired Pneumonia
Interventions: DRUG: Moxifloxacin|DRUG: Ampicillin;Amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeted Steroids for ARDS Due to COVID-19 Pneumonia: A Pilot Randomized Clinical Trial
Status: WITHDRAWN
Conditions: COVID-19|ARDS
Interventions: DRUG: Dexamethasone injection|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Meningococcal Conjugate Vaccine (GSK134612) When Co-administered With Boostrix® in Subjects Between 11 and 25 Years of Age
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: Meningococcal vaccine GSK134612|BIOLOGICAL: Boostrix®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Amifostine, Chemotherapy, and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Drug/Agent Toxicity by Tissue/Organ|Lung Cancer|Radiation Toxicity
Interventions: DRUG: amifostine trihydrate|DRUG: cisplatin|DRUG: etoposide|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Physical Activity and Sedentary Lifestyle During Pregnancy: Feasibility and Impact Study on Sedentary Behavior
Status: COMPLETED
Conditions: Sedentary Behavior|Pregnancy Related|Perinatal Problems|Sedentary Time|Morbidity;Perinatal
Interventions: OTHER: Physical activity sessions for pregnant women
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase III Study to Evaluate the Efficacy and Safety of AD-209
Status: RECRUITING
Conditions: Hypertension,Essential
Interventions: DRUG: AD-209|DRUG: AD-2091|DRUG: AD-209 Placebo|DRUG: AD-2091 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The IRESSA Novel Head and Neck Chemotherapy Evaluation Study
Status: COMPLETED
Conditions: Squamous Cell Cancer|Cancer of Head and Neck
Interventions: DRUG: gefitinib|DRUG: cisplatin|DRUG: 5-flourouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Glucose on Bone - Direct og Indirect?
Status: UNKNOWN
Conditions: Glucose Infusion|Bone Markers|Inflammatory Markers
Interventions: OTHER: Oral Glucose Tolerance Test (OGTT)|OTHER: Intravenous Glucose Tolerance Test (IVGTT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Radiofrequency Ablation in Treating Patients With Stage I Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: PROCEDURE: Computed Tomography-Guided Optical Sensor-Guided Radiofrequency Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Helicobacter Pylori Eradication in Children With Chronic Immune Thrombocytopenic Purpura
Status: UNKNOWN
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Amoxicillin 50 mg/kg/day in 2 divided doses for 14 days.|DRUG: Clarithromycin 15 mg/kg/day in 2 divided doses for 14 days.|DRUG: Proton pump inhibitor 1 mg/kg/day in 2 divided doses 1 month
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Pharmacokinetics, Pharmacodynamics, and Safety of Canagliflozin (JNJ-28431754) in Volunteers With Varying Degrees of Kidney Function
Status: COMPLETED
Conditions: Renal Insufficiency|Healthy
Interventions: DRUG: Canagliflozin (JNJ-28431754)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ivermectin-albendazole vs Albendazole Alone in School-aged Children Infected With Trichuris Trichiura
Status: COMPLETED
Conditions: Trichuriasis
Interventions: DRUG: IVM (200 µg/kg) + ALB (400 mg)|DRUG: ALB (400mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Yoga for Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BEHAVIORAL: Yoga program|BEHAVIORAL: Arthritis-education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Response of the Immune System of Patients With End Stage Kidney Disease on Dialysis and Kidney Transplant Recipients Vaccinated for COVID-19
Status: UNKNOWN
Conditions: End Stage Kidney Disease|Kidney Transplantion|Covid19|Vaccination
Interventions: BIOLOGICAL: SARS - COV 2 VACCINE
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exparel vs. Standard Bupivicaine for Abdominoplasty
Status: TERMINATED
Conditions: Pain, Postoperative
Interventions: DRUG: Liposomal Injection Bupivacaine (Exparel)|DRUG: Standard bupivicaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: BK With VST for Kidney Transplant Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Transplant Infection|BK Virus Infection
Interventions: DRUG: BK-specific T cells from Donor Lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: H5N1 With or Without Topical Aldara in Healthy Adults
Status: COMPLETED
Conditions: Avian Influenza|Influenza Immunisation
Interventions: OTHER: Aqueous Cream B.P.|DRUG: Imiquimod|BIOLOGICAL: Influenza Virus Vaccine, Monovalent A/H5N1 A/Vietnam/1203/04
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of m-RESIST, an m-Health Program for Treatment-resistant Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DEVICE: m-RESIST Patients|DEVICE: m-RESIST Caregivers
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ctDNA Methylation for Detecting Ovarian Cancer
Status: RECRUITING
Conditions: Epithelial Ovarian Cancer|Circulating Tumor DNA|DNA Methylation|Non-invasive Diagnosis|CA125|Human Epididymis Protein 4|ROMA Index|Imaging Evaluation|Survival Prognosis
Interventions: DIAGNOSTIC_TEST: Methylation assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Effectiveness Study of Imiquimod Creams for Treatment of Actinic Keratoses (AKs)
Status: COMPLETED
Conditions: Actinic Keratoses
Interventions: DRUG: imiquimod cream|DRUG: imiquimod cream|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Audiovisuell Distraction Via 2d Videoglasses During Catheter Ablation Procedures in Cardiac Rhythm Disorders.
Status: COMPLETED
Conditions: Rhythm; Disorder
Interventions: DEVICE: Audiovisual distraction using 2d video glasses from HappyMed GmbH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of 28 or 56 Day Treatment for Pseudomonas Aeruginosa in Children With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Tobramycin solution for inhalation 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Focal Implant Used for Lower Extremity Post-angioplasty Dissection
Status: NOT_YET_RECRUITING
Conditions: Peripheral Artery Disease
Interventions: DEVICE: the spot stent(ZENFLEX ® Pinto) system|DEVICE: the bare stent( Everflex) system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Epigenetic Effects Elicited By Lactobacillus GG In Children With Cow's Milk Allergy
Status: UNKNOWN
Conditions: Cow's Milk Allergy
Interventions: DIETARY_SUPPLEMENT: Lactobacillus GG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Pulmonary Vein Isolation Versus AV Nodal Ablation With Biventricular Pacing for Patients With Atrial Fibrillation With Congestive Heart Failure (PABA CHF)
Status: COMPLETED
Conditions: Atrial Fibrillation|Congestive Heart Failure
Interventions: PROCEDURE: Pulmonary vein isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In Vivo Quantification of Short Chain Fatty Acids Production in the Human Colon
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Arabinoxylan oligosaccharides|DIETARY_SUPPLEMENT: Dietary fiber enriched bran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Metformin+Cytarabine for the Treatment of Relapsed/Refractory AML
Status: TERMINATED
Conditions: Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Blastic Phase Chronic Myelogenous Leukemia|Recurrent Adult Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: metformin hydrochloride|DRUG: cytarabine|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-Assembled Modified Macintosh Videolaryngoscope Versus McGrath Macintosh (MAC®) Videolaryngoscope: Which is Better?
Status: COMPLETED
Conditions: Airway Management
Interventions: DEVICE: Endotracheal intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Association Between Fluid Administration, Oxytocin Administration, and Fetal Heart Rate Changes
Status: TERMINATED
Conditions: Pregnancy|Labor Pain
Interventions: DRUG: Group A Intravenous bolus of 1000 ml lactated ringers solution|DRUG: Group B Intravenous bolus bolus 1000 ml lactated ringers solution oxytocin decrease to 1/2 current rate|DRUG: Group C 125 mL/hr of lactated ringers|DRUG: Group D 125 mL/hr lactated ringers oxytocin decreased to 1/2 current rate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Artificial Cycle With or Without GnRH Agonist Pre-treatment for Frozen Embryo Transfer in Adenomyosis Patients
Status: RECRUITING
Conditions: Adenomyosis|IVF|Frozen Embryo Transfer
Interventions: PROCEDURE: GnRHa+AI - AC|PROCEDURE: Artificial cycle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Stable Epilepsy Patients Comparing Brand and Generic Divalproex Sodium Extended Release Tablets
Status: UNKNOWN
Conditions: Epilepsy
Interventions: DRUG: Divalproex Sodium Extended-release 250mg|DRUG: DEPAKOTE 250mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Multi-Site Study of the Zyga GlyDer Facet Restoration Device In Subjects With LUmbar FacET Pain Syndrome - DUET
Status: TERMINATED
Conditions: Facet Joint Pain
Interventions: DEVICE: Glyder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CTT1057, a Small Molecular Inhibitor of PSMA, as a Novel Imaging Agent of Neovascularization in Renal Cell Carcinoma
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: CTT1057
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Non Inferiority Study of a Reduced Dose of Activated Charcoal on Rivaroxaban Pharmacokinetics.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rivaroxaban|DRUG: Activated charcoal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Hypolipemic Treatment on Adipokines
Status: COMPLETED
Conditions: Hyperlipidemia|Impaired Fasting Glycemia
Interventions: DRUG: To compare monotherapies and combined therapy with each other
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Biomarker Approach to Screening for the Early Detection of HPV-related Oropharyngeal Cancer (BASH OPC)
Status: RECRUITING
Conditions: Oropharyngeal Cancer|HPV-Related Carcinoma
Interventions: DIAGNOSTIC_TEST: combined HPV 16 DNA and host gene methylation oral biomarker panel
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pulmonary Function, Chronic Obstructive Pulmonary Disease (COPD) Prevalence, and Systemic Inflammation in Chronic Heart Failure With or Without COPD
Status: COMPLETED
Conditions: Heart Failure|Pulmonary Disease, Chronic Obstructive|Inflammation
Interventions: OTHER: Pulmonary function tests|OTHER: Blood tests|OTHER: Questionnaires|OTHER: Chest radiograph
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Neurogenic Overactive Bladder
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: BIOLOGICAL: botulinum toxin Type A (200U)|BIOLOGICAL: botulinum toxin Type A (300U)|OTHER: Normal Saline (Placebo); botulinum toxin Type A (200U)|OTHER: Normal Saline (Placebo); botulinum toxin Type A (300U)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Bioavailability Study of Omexa Sumatriptan vs. Imitrex® in Healthy Volunteers
Status: UNKNOWN
Conditions: Migraine
Interventions: DRUG: Omexa Sublingual Sumatriptan tablet|DRUG: Imitrex Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risedronate 75mg Dosed on 2 Consecutive Days Monthly in the Treatment of Osteoporosis in Postmenopausal Women
Status: COMPLETED
Conditions: Osteoporosis Postmenopausal
Interventions: DRUG: Risedronate (HMR4003)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Predict Fluid Responsiveness in Spinal Anesthesia
Status: COMPLETED
Conditions: Hypotension and Shock|Excessive Amount of Blood / Fluid Infusion
Interventions: PROCEDURE: Trans-thoracic echocardiography|PROCEDURE: Passive Leg Raising Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: EEG Studies of IV Methylphenidate-Induced Emergence From Anesthesia
Status: WITHDRAWN
Conditions: Active Emergence From General Anesthesia
Interventions: DRUG: IV methylphenidate|DRUG: Placebo|DRUG: Sevoflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Safety and Immunogenicity of Non-live, Recombinant Subunit Herpes Zoster Vaccine Before and After Lung Transplantation
Status: UNKNOWN
Conditions: Varicella Zoster Vaccine
Interventions: BIOLOGICAL: VZV subunit vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Inhaled Nitric Oxide (iNO) for Congenital Diaphragmatic Hernia (CDH) - The "NoNO Trial" - a Multi-center, De-implementation, Stepped-wedge, Cluster-randomized Trial Within an Established Collaborative
Status: NOT_YET_RECRUITING
Conditions: Congenital Diaphragmatic Hernia
Interventions: DRUG: Inhaled Nitric Oxide (iNO) use|OTHER: De-implementation of Inhaled Nitric Oxide (iNO) use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spectroscopic and Diffusion Weighted Analysis of the Effects of Dexamethasone on High Altitude Cerebral Oedema (HACE)
Status: COMPLETED
Conditions: High Altitude Cerebral Edema
Interventions: DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PCORI-1310-06998 Trial of a Decision Support Intervention for Patients and Caregivers Offered Destination Therapy Heart Assist Device
Status: COMPLETED
Conditions: Heart Failure|Heart-assist Devices
Interventions: BEHAVIORAL: DT LVAD Decision Support Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bilateral Erector Spinae Plane Block for Management of Acute Postoperative Pain After Pediatric Cardiac Surgeries Through a Midline Sternotomy
Status: UNKNOWN
Conditions: Cardiac Surgery
Interventions: OTHER: Erector spinae catheters insertion|DRUG: Postoperative pain management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: a Pilot Study of Lidocaine Infusion for Postoperative Analgesia in Elderly Patients With Colorectal Cancer Surgery
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Lidocaine Hydrochloride 2% Injection Solution|DRUG: 0.9% NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Obesity, Inflammation and Oxidative Stress
Status: COMPLETED
Conditions: C-reactive Protein|Inflammation|Obesity|Oxidative Stress
Interventions: DIETARY_SUPPLEMENT: Vitamin C (ascorbic acid)|DIETARY_SUPPLEMENT: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Sleep Restrictions on Maximal Strength, Muscle Power, and Strength Endurance in Resistance-trained Women.
Status: ENROLLING_BY_INVITATION
Conditions: Sleep Restriction|Sleep
Interventions: PROCEDURE: Sleep restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase 1&2 Study to Evaluate the Safety & Efficacy of Inhaled IBIO123 in Severe COVID-19 Illness
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: IBIO123|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Residual Symptoms and the Quality of Life in Individuals Recovered From COVID-19 Infection: A Survey From Pakistan
Status: COMPLETED
Conditions: COVID-19 Pandemic|COVID-19 Respiratory Infection|COVID-19 Lower Respiratory Infection
Interventions: OTHER: Residual Symptoms and the Quality of Life in Individuals Recovered from COVID-19 Infection: A Survey from Pakistan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Decitabine and Selinexor in Combination to Reverse Drug Resistance With Standard Chemotherapy in Ovarian Cancer
Status: RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: Decitabine|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug-drug Interaction Study of Avapritinib and Midazolam
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastrointestinal Stromal Tumors|GIST|Non-resectable Advanced Solid Tumors|Recurrent or Unresectable Central Nervous System (CNS) Tumors
Interventions: DRUG: Avapritinib|DRUG: midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Adjuvant Versus Progression-Triggered Gemcitabine Monotherapy for Locally Advanced Bladder Cancer
Status: UNKNOWN
Conditions: Bladder Cancer|Carcinoma, Transitional Cell
Interventions: DRUG: gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of C1-esterase Inhibitor on Systemic Inflammation in Trauma Patients With a Femur or Pelvic Fracture
Status: TERMINATED
Conditions: Trauma|Inflammation|Sepsis|Multiple Organ Dysfunction Syndrome
Interventions: DRUG: C1-esterase inhibitor|OTHER: Saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Supplementation of Brown Seaweed on Insulin Resistance of NAFLD Patients With Pre- or Type 2-Diabetes
Status: UNKNOWN
Conditions: Type II Diabetes
Interventions: DIETARY_SUPPLEMENT: Brown seaweed|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase III Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine for Tourette Syndrome and Attention Deficit Hyperactivity Disorder
Status: COMPLETED
Conditions: Tourette Syndrome
Interventions: DRUG: guanfacine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Improving Maximal Strength in the Initial Postoperative Phase After Anterior Cruciate Ligament Reconstruction Surgery: Randomized Controlled Trial of an App-Based Serious Gaming Approac
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Rupture
Interventions: DEVICE: App based Serious Gaming with the Genu Sport knee trainer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation in Children With Sickle Cell Disease
Status: UNKNOWN
Conditions: Children With Sickle Cell Disease at Mulago Hospital
Interventions: DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Daily Single Dose Triple and Conventional Triple Therapies for Helicobacter Pylori Infection
Status: COMPLETED
Conditions: Helicobacter Infection
Interventions: DRUG: Nexium|DRUG: Tinafas|DRUG: Tavanex|DRUG: Lanzol|DRUG: Klacid|DRUG: Iramox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Clinical Trial to Evaluate Safety and Effectiveness of CAF + Mucograft® Compared to CAF Alone in Patients With Gingival Recessions
Status: COMPLETED
Conditions: Gingival Recession
Interventions: DEVICE: Mucograft|PROCEDURE: Coronally advanced flap (CAF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamics and Non-Clinical Inferiority of Heparin Sodium (Cristália) Compared With the Product Liquemine (Roche) in Chronic Renal Failure
Status: COMPLETED
Conditions: Chronic Renal Failure
Interventions: BIOLOGICAL: Heparin sodic - Cristália|BIOLOGICAL: heparin - Liquemine (Roche)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment and Prevention of Middle Ear Morbidity in Head and Neck Cancer Patients Following Radiotherapy
Status: COMPLETED
Conditions: Otitis Media With Effusion|Chronic Otitis Media|Hearing Loss
Interventions: DEVICE: Otovent®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 1 Study for Safety and Tolerability of IL-1-Ra Topically Administered to Eyes of Healthy Adult Subjects
Status: UNKNOWN
Conditions: Blepharokeratoconjunctivitis
Interventions: DRUG: IL-1Ra
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lumateperone Monotherapy for the Treatment of Bipolar Depression Conducted Globally
Status: COMPLETED
Conditions: Bipolar Depression
Interventions: DRUG: Lumateperone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-blind Study to Evaluate the Clinical Effect and Safety of Fucoidan in Patients With Squamous Cell Carcinomas of the Head and Neck
Status: RECRUITING
Conditions: Squamous Cell Carcinomas of the Head and Neck
Interventions: DIETARY_SUPPLEMENT: Fucoidan|OTHER: Placebo( Potato starch)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Futibatinib in Patients With Advanced Cholangiocarcinoma With FGFR2 Fusion or Rearrangement
Status: RECRUITING
Conditions: Advanced Cholangiocarcinoma|FGFR2 Fusions|Gene Rearrangement
Interventions: DRUG: TAS-120
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HistScanning- Based PDR Brachytherapy in Prostate Cancer HistoScanning- Based Interstitial PDR Brachytherapy
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: RADIATION: brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TNS for Major Depressive Disorder: a Phase II Randomized Controlled Trial
Status: UNKNOWN
Conditions: Depressive Symptoms
Interventions: DEVICE: Trigeminal Nerve Stimulation (TNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Monoclonal Antibody Therapy, Paclitaxel, and Cyclosporine in Treating Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: BIOLOGICAL: monoclonal antibody Lym-1|DRUG: cyclosporine|DRUG: paclitaxel|RADIATION: indium In 111 monoclonal antibody Lym-1|RADIATION: yttrium Y 90 monoclonal antibody Lym-1
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Translational Neuroscience Optimization of GlyT1 Inhibitor
Status: COMPLETED
Conditions: Cognitive Impairments Associated With Schizophrenia
Interventions: DRUG: PF-03463275|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Cardiopulmonary Bypass (CPB)-Leukocyte Filtration on Interleukins Serum Levels and Pulmonary Function
Status: COMPLETED
Conditions: Systemic Inflammatory Response Syndrome (SIRS)|Leukocyte Disorders|Complications Due to Coronary Artery Bypass Graft
Interventions: DEVICE: Filtering group LG-6, Pall Biomedical Products
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety and Efficacy of CB-03-01 Cream, 1% in Subjects With Facial Acne Vulgaris (26)
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: CB-03-01 cream, 1%|DRUG: Vehicle cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cixutumumab, Everolimus, and Octreotide Acetate in Treating Patients With Advanced Low to Intermediate Grade Neuroendocrine Carcinoma
Status: COMPLETED
Conditions: Gastrin-Producing Neuroendocrine Tumor|Lung Carcinoid Tumor|Metastatic Digestive System Neuroendocrine Tumor G1|Pancreatic Glucagonoma|Pancreatic Insulinoma|Pancreatic Polypeptide Tumor|Paraganglioma|Recurrent Digestive System Neuroendocrine Tumor G1|Recurrent Merkel Cell Carcinoma|Recurrent Pancreatic Neuroendocrine Carcinoma|Regional Digestive System Neuroendocrine Tumor G1|Somatostatin-Producing Neuroendocrine Tumor|Stage III Merkel Cell Carcinoma|Stage IV Merkel Cell Carcinoma|Thyroid Gland Medullary Carcinoma
Interventions: BIOLOGICAL: Cixutumumab|DRUG: Everolimus|OTHER: Laboratory Biomarker Analysis|DRUG: Octreotide Acetate|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Behavioral Exposure for Introceptive Tolerance RCT
Status: RECRUITING
Conditions: Exercise Sensitivity|Introceptive Exposure|Anxiety|Cardiac Rehabilitation
Interventions: BEHAVIORAL: Behavioral Exposure For Introceptive Tolerance|BEHAVIORAL: Health Education Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness and Cost-effectiveness of Integrated Model for Malaria and Helminth Control
Status: NOT_YET_RECRUITING
Conditions: Malaria|Soil Transmitted Helminths|Schistosomiasis|Seasonal Malaria Chemoprevention|Mass Drug Administration With Anthelminthic Drugs
Interventions: DRUG: Sulphadoxine-pyrimethamine and Amodiaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Human Immune Responses Vaccination in Patients With Lymphoma
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Diffuse Large B-Cell Lymphoma|Follicular Lymphoma|Mantle Cell Lymphoma|Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: Inactivated Influenza Vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study in Healthy People to Test if Taking Different Formulations of BI 425809 Tablets Influences the Amount of BI 425809 in the Blood
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 425809 (Treatment T1)|DRUG: BI 425809 (Treatment T2)|DRUG: BI 425809 (Treatment R)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: bTAE-HAIC Combined With System Therapy for Intermediate-advanced Huge HCC
Status: RECRUITING
Conditions: Liver Diseases|Hepatocellular Carcinoma|Immunotherapy|Camrelizumab|Lenvatinib
Interventions: PROCEDURE: bTAE-HAIC|DRUG: Lenvatinib|DRUG: Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Remote Monitoring to Address Health Disparities in Type 2 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: Blood glucose monitor with Digital Platform and Health Coaching|DEVICE: Continuous glucose monitor|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Olaparib Before Surgery in Treating Participants With Localized Prostate Cancer
Status: TERMINATED
Conditions: Prostate Adenocarcinoma Without Neuroendocrine Differentiation|Stage I Prostate Cancer AJCC v8|Stage II Prostate Cancer AJCC v8|Stage IIA Prostate Cancer AJCC v8|Stage IIB Prostate Cancer AJCC v8|Stage IIC Prostate Cancer AJCC v8
Interventions: DRUG: Olaparib|PROCEDURE: Radical Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online Peri-operative Education Program for Patients Undergoing Major Head & Neck Surgery
Status: RECRUITING
Conditions: Head and Neck Cancer|Head and Neck Neoplasms
Interventions: OTHER: CareOrbit
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessing Exercise Capacity After PulseHaler™ Treatment in GOLD II-IV COPD Patients
Status: UNKNOWN
Conditions: COPD
Interventions: DEVICE: PulseHaler|DEVICE: Sham - control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intrapartum Sildenafil Citrate to Prevent Non Reassuring Foetal Status Among Parturients Delivering at Term
Status: UNKNOWN
Conditions: Foetal Hypoxia
Interventions: DRUG: Sildenafil citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: BIBW 2992 After Administration of Docetaxel in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Docetaxel|DRUG: BIBW 2992
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ad26.COV2.S in Adults (COVID-19)
Status: COMPLETED
Conditions: Covid-19 Prevention
Interventions: BIOLOGICAL: Ad26.COV2.S|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Adjuvant Treatment With 177Lu-DOTATATE to Best Supportive Care in Patients After Resection of Neuroendocrine Liver Metastases
Status: RECRUITING
Conditions: Neuroendocrine Tumor G1 (NET G1)/Carcinoid|Neuroendocrine Tumor Grade 2|Neuroendocrine Tumors|Liver Metastases|Gastroenteropancreatic Neuroendocrine Tumor|Gastroenteropancreatic Neuroendocrine Neoplasm
Interventions: DRUG: Lutathera
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Product Surveillance Registry
Status: RECRUITING
Conditions: Cardiac Rhythm Disorders|Urological Disorders|Neurological Disorders|Cardiovascular Disorders|Digestive Disorders|Intracranial Aneurysm|Mechanical Circulatory Support|Respiratory Therapy|Aortic, Peripheral Vascular and Venous Disorders|Minimally Invasive Surgical Procedures|Diagnostic Techniques and Procedures|Surgical Procedures, Operative|Renal Insufficiency|Neurovascular|Coronary Artery Disease|Ear, Nose and Throat Disorder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Sorafenib With or Without VT-122 in Patients With Hepatocellular Carcinoma (HCC)
Status: UNKNOWN
Conditions: HCC
Interventions: DRUG: Sorafenib|DRUG: VT-122 (propranolol plus etodolac)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Diabetes on Short İmplants in One- and Two-Stage Surgeries
Status: NOT_YET_RECRUITING
Conditions: Dental Implant Surgical Techniques|Diabetes Mellitus|Short Dental Implants
Interventions: PROCEDURE: One stage implant surgery|PROCEDURE: Two stage implant surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Houston Emergency Opioid Engagement System
Status: ENROLLING_BY_INVITATION
Conditions: Opioid Use Disorder
Interventions: DRUG: Suboxone|BEHAVIORAL: Brief counseling in the ED|BEHAVIORAL: Referral to outpatient treatment|BEHAVIORAL: Follow-up coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ActivityChoice: Implementing Clinic-Based Physical Activity Program Choices for Cancer Survivors
Status: ENROLLING_BY_INVITATION
Conditions: Cancer|Cardiovascular Diseases|Physical Inactivity
Interventions: BEHAVIORAL: Enhanced Referral|BEHAVIORAL: Standard Referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: EUS-guided Intra-tumour Injection of OncoSil for Locally Advanced Pancreatic Carcinoma.
Status: RECRUITING
Conditions: Pancreatic Cancer|Endoscopic Ultrasound
Interventions: DEVICE: EUS-guided oncosil injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Metastatic, Recurrent or Primary Unresectable Pheochromocytoma/Paraganglioma
Status: COMPLETED
Conditions: Pheochromocytoma|Paraganglioma
Interventions: DRUG: Axitinib (AG-013736)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Assessment of POCD After TURBT Under Spinal Anesthesia
Status: UNKNOWN
Conditions: Bladder Tumor|Postoperative Cognitive Dysfunction
Interventions: DRUG: benzodiazepines|DRUG: opioid|PROCEDURE: spinal anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Ibrutinib, Lenalidomide and Rituximab for Patients With Relapsed/Refractory Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Relapsed/Refractory Mantle Cell Lymphoma
Interventions: DRUG: Lenalidomide|DRUG: Ibrutinib|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Podofilox Topical Gel 0.5% and Allergan's Condylox® Gel 0.5% for External Anogenital Warts
Status: COMPLETED
Conditions: External Anogenital Warts
Interventions: DRUG: Podofilox Gel 0.5%|DRUG: Condylox Topical Gel 0.5%|DRUG: Placebo Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Short-Term Prednisone Therapy on C-Reactive Protein Change in Emergency Department Patients With Acute Heart Failure and Elevated Inflammatory Markers ( CORTAHF )
Status: RECRUITING
Conditions: Acute Heart Failure
Interventions: DRUG: Prednisone arm|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT