pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Development and Evaluation of a Single Session Intervention for Parent Distress Tolerance
Status: ENROLLING_BY_INVITATION
Conditions: Parents|Mental Health Issue|Distress, Emotional
Interventions: BEHAVIORAL: Parents THRIVE|BEHAVIORAL: Sharing Feelings Project
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacist Interventions in Rural Elderly Warfarin Patients
Status: COMPLETED
Conditions: Atrial Fibrillation|Thrombosis|Cardiac Failure|Hemorrhage
Interventions: OTHER: anticoagulation care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cream Containing Sericin and Turmeric in Psoriasis Patients
Status: NOT_YET_RECRUITING
Conditions: Psoriasis
Interventions: DRUG: Sericin extract and turmeric extract cream|DRUG: Triamcinolone acetonide 1% Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Substance Abuse Treatment to HIV Care (SAT2HIV): The Implementation & Sustainment Facilitation Experiment
Status: COMPLETED
Conditions: Substance Use
Interventions: BEHAVIORAL: ATTC strategy|BEHAVIORAL: ISF strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Randomized-Controlled Trial of Inhaled Hypertonic Saline (7%) to Evaluate the Lung Clearance Index
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Hypertonic Saline 7%|DRUG: Isotonic Saline 0.9% (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exploration of the Potential Mechanisms of n-3 Fatty Acids Supplementation in Depression and Cognitive Function in Patients With Late-life Depression
Status: COMPLETED
Conditions: Late Life Depression
Interventions: OTHER: Omega-3 fatty acids|OTHER: Soybean oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: XmAb23104 (PD1 X ICOS) and XmAb22841 (CTLA-4 X LAG3) in Treating Melanoma Prior Immune Checkpoint Inhibitor Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Melanoma|Advanced Melanoma
Interventions: DRUG: XmAb22841|DRUG: XmAb23104
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Efficacy of Different Dosages of Lercanidipine to Reduce Hypertensive Blood Pressure in Normal Weight and Obese Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Lercanidipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: The Use of Statins Following a Left Atrial Catheter Ablation Procedure to Prevent Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation|Arrhythmia|Inflammation|Endothelial Dysfunction
Interventions: DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Magnetic Resonance Imaging in Patients With Non-Hodgkin Lymphoma or Hodgkin Lymphoma Receiving Doxorubicin
Status: COMPLETED
Conditions: Cardiac Toxicity|Chemotherapeutic Agent Toxicity|Lymphoma
Interventions: PROCEDURE: contrast-enhanced magnetic resonance imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Simple Walking Program to Enhance Concurrent Chemoradiotherapy Delivery
Status: COMPLETED
Conditions: Brain Cancer|Head and Neck Cancer|Lung Cancer|Gastrointestinal Cancer|Cervical Cancer
Interventions: BEHAVIORAL: Pedometer-based Walking Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Immunoadsorption Study Mainz in Adults With Post-COVID Syndrome
Status: RECRUITING
Conditions: Post-COVID-19 Syndrome|Post-COVID Syndrome|Post COVID-19 Condition
Interventions: DEVICE: Immunoadsorption|DEVICE: Sham-apheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Health Evaluation of Mushrooms withVitamin D2
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Pleurotus citrinopileatus after bio-optics (10 ug group)|DIETARY_SUPPLEMENT: Pleurotus citrinopileatus after bio-optics (100 ug group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Adjuvant Post-radical Cystectomy Treatment for Bladder Cancer
Status: COMPLETED
Conditions: Locally Advanced Bladder Cancer
Interventions: RADIATION: Radiation|DRUG: gemcitabine and cisplatin|OTHER: Radiotherapy and Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Outcomes Following Intralesional Corticosteroid Injections
Status: COMPLETED
Conditions: Keloid|Alopecia Areata|Acne|Hypertrophic Scar|Epidermal Inclusion Cyst|Frontal Fibrosing Alopecia|Lichen Plano-Pilaris|Keratoacanthoma|Plaque Psoriasis|Lichen Simplex Chronicus|Prurigo Nodularis|Nummular Eczema|Granuloma Annulare|Morphea|Lichen Planus
Interventions: DRUG: Corticosteroid with lidocaine|DRUG: Corticosteroid with normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BETH Study: Treatment of HER2 Positive Breast Cancer With Chemotherapy Plus Trastuzumab vs Chemotherapy Plus Trastuzumab Plus Bevacizumab
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: Trastuzumab|DRUG: Carboplatin|DRUG: Bevacizumab|DRUG: 5-Fluorouracil|DRUG: Epirubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare the Efficacy of Different Laryngeal Mask Size Selection Methods in General Anesthesia in Children
Status: COMPLETED
Conditions: Airway Management
Interventions: PROCEDURE: use the three-finger method|PROCEDURE: use the weight-related method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Furosemide in Premature Infants at Risk of Bronchopulmonary Dysplasia (BPD)
Status: COMPLETED
Conditions: Bronchopulmonary Dysplasia
Interventions: DRUG: Furosemide Cohort 1|DRUG: Furosemide Cohort 2|DRUG: Furosemide Cohort 3|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Ankle Manual Therapy for Ankle Sprains
Status: SUSPENDED
Conditions: Sprains and Strains
Interventions: OTHER: Passive Positioning|OTHER: High-Velocity, Low-Amplitude Stretch|OTHER: Slow, Mobilization Stretch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physiologic Growth Hormone Effects in HIV Lipodystrophy
Status: COMPLETED
Conditions: AIDS|HIV Infections
Interventions: DRUG: recombinant human growth hormone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Restoration of Cutaneous Sensorum in Patients With Diabetic Peripheral Neuropathy (DPN) Via Metanx®
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathy
Interventions: OTHER: Metanx® (Oral L-methylfolate, Methylcobalamin and Pyridoxal 5'-phosphate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Mosquito-Lethal Effects of Ivermectin (IVM), Primaquine (PQ), Dihydroartemisinin-Piperaquine (DHA-PQP) and Albendazole (ABZ) in Healthy Subjects
Status: COMPLETED
Conditions: Drug Combination|Pharmacokinetics|Healthy
Interventions: DRUG: IVM, IVM and PQ, IVM and DHA-PQP, IVM and DHA-PQP and PQ|DRUG: PQ and DHA-PQP and PQ|DRUG: DHA-PQP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of The Pregnant Follow-Up Conducted With Home Visits on The Perinatal Outcomes
Status: UNKNOWN
Conditions: Pregnancy Related|Prenatal Care Late
Interventions: BEHAVIORAL: Antenatal care and prenatal education with a home visit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Opt-IVF Multi-center Trial 2 Including All Protocols
Status: COMPLETED
Conditions: IVF
Interventions: DEVICE: OPTIVF dosage|DEVICE: traditional Dosage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Textured Insoles and Foot Massage in Individuals Diagnosed With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: OTHER: plantar massage|OTHER: textured insoles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Midazolam for Pediatric Pre-procedural Sedation and Pre-procedural Anti-anxiety Using sipNose Device - a Randomized Controlled Study
Status: UNKNOWN
Conditions: Procedural Sedation|Intra-nasal Delevery Device
Interventions: DEVICE: Sipnose device|DEVICE: MAD (Mucosal Atomization Device)|DRUG: midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validity of a Supersimplified Device for Diagnosis of Patients With Suspected Obstructive Sleep Apnoea-hypopnoea (OSAH)
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea
Interventions: PROCEDURE: PSG|PROCEDURE: MicroMESAM system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmaco-Scintigraphic Study to Evaluate the Release Profile of Metronidazole Benzoate Capsules
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Metronidazole Benzoate gastro-resistant capsule with radio-labelled mucoadhesive formulation|DRUG: Metronidazole Benzoate gastro-resistant capsule with radio-labelled non-mucoadhesive formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PK/PD Properties and Safety of Remazolam Besylate for Injection in ICU Patients With Impaired Renal Function
Status: RECRUITING
Conditions: Mechanically Ventilated Patients
Interventions: DRUG: Remimazolam besylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Locally Delivered Whey Protein Nanoparticles Gel in Stage II Grade B Periodontitis
Status: RECRUITING
Conditions: Periodontitis Chronic Localized Slight
Interventions: DRUG: placebo gel|DRUG: CWP gel|DRUG: NCWP gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2a Study of ABT-263 in Subjects With Small Cell Lung Cancer (SCLC) or Other Non-Hematological Malignancies
Status: COMPLETED
Conditions: Small Cell Lung Cancer|Small Cell Lung Carcinoma
Interventions: DRUG: ABT-263
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Adjuvant Atezolizumab or Atezolizumab Plus Tiragolumab in Solid Tumors With Resectable Disease With Intermediate-High Risk of Recurrence and High Tumor Mutational Burden (TMB-H) or Microsatellite Instability (MSI-H)
Status: RECRUITING
Conditions: Solid Tumors
Interventions: DRUG: Atezolizumab|DRUG: Tiragolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non Invasive Assessment of Liver Glycogen Kinetics and ATP Synthesis in Type1 Diabetics
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: PROCEDURE: magnet resonance spectroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Acupuncture in Infantile Colic - A Randomised Trial.
Status: RECRUITING
Conditions: Infant, Newborn, Diseases|Colic, Infantile|Acupuncture
Interventions: OTHER: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: ExclUsive endocRine Therapy Or Radiation theraPy for Women Aged ≥70 Years Early Stage Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: RADIATION: Breast irradiation (RT)|DRUG: Endocrine Therapy (ET): letrozole, anastrozole, exemestane, tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bone Marrow Transplantation in Treating Patients With Hematologic Cancer
Status: COMPLETED
Conditions: Anemia|Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: anti-thymocyte globulin|BIOLOGICAL: filgrastim|DRUG: cyclophosphamide|DRUG: thiotepa|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: bone marrow ablation with stem cell support|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of Imatinib and Valproic Acid in Patients With Chronic Myelogenous Leukemia (CML)
Status: WITHDRAWN
Conditions: Chronic Myelogenous Leukemia
Interventions: DRUG: Gleevec (imatinib), valproic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study of VSA001 in Chinese Adults With Familial Chylomicronemia Syndrome
Status: NOT_YET_RECRUITING
Conditions: Familial Chylomicronemia Syndrome
Interventions: DRUG: VSA001 injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Recovery of Diaphragmatic Function After Neuromuscular Blockade and Sugammadex
Status: COMPLETED
Conditions: Diaphragmatic Dysfunction|Muscle Weakness|Muscle Fatigue
Interventions: DRUG: sugammadex 2mg/kg|DRUG: neostigmine|DRUG: sugammadex 4mg/kg|DRUG: placebo|DRUG: Single rocuronium dose|DRUG: Repeated rocuronium dose|DRUG: Continuous rocuronium infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quantifying the Benefits and Cost-effectiveness of Real-Ear Measurements (REM) for Hearing Aid Fitting
Status: RECRUITING
Conditions: Sensorineural Hearing Loss, Bilateral
Interventions: OTHER: Hearing Aid Manufacturer's Software|OTHER: REM (Real Ear Measurements)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Intracorneal Ring Segments on Posterior Corneal Tomography in Eyes With Keratoconus
Status: COMPLETED
Conditions: Keratoconus|Keratoconus Posterior
Interventions: PROCEDURE: Intracorneal ring segment implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Onset and Duration of Action of Bepotastine Besilate Ophthalmic Solution in Acute Allergic Conjunctivitis
Status: COMPLETED
Conditions: Conjunctivitis, Allergic
Interventions: DRUG: Bepreve|DRUG: Placebo|DRUG: Bepotastine Besilate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Chinese Herbal Compound Dendrobium Huoshanense Granules in NCRT for Patients With Locally Advanced Rectal Cancer
Status: UNKNOWN
Conditions: Locally Advanced Rectal Cancer
Interventions: DRUG: Dendrobium Huoshanense Granules|RADIATION: Pelvic Radiation|DRUG: Capecitabine|DRUG: Irinotecan|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Alpha Lipoic Acid in Pediatrics on Hemodialysis
Status: NOT_YET_RECRUITING
Conditions: Hemodialysis Complication|Pediatric Kidney Disease|Cardiovascular Complication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of Use of Paravertebral Blocks for Pain Relief in Video Assisted Lung Surgery
Status: COMPLETED
Conditions: Lung Tumour|Lung Metastases
Interventions: PROCEDURE: Early paravertebral block|PROCEDURE: Late Paravertebral block.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Degenerative Arthritis
Status: COMPLETED
Conditions: Degenerative Arthritis
Interventions: PROCEDURE: Autologous Adipose Tissue derived MSCs Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biological Effects of LEO 43204 in Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: LEO 43204 Gel, 0.037%|DRUG: LEO 43204 Gel, 0.037%
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Levomilnacipran ER vs. Adjunctive Quetiapine for Adults With Inadequate Relief With SSRIs in MDD
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Levomilnacipran|DRUG: Quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First-in-human Study of Oral TP-0903 (a Novel Inhibitor of AXL Kinase) in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors|EGFR Positive Non-small Cell Lung Cancer|Colorectal Carcinoma|Recurrent Ovarian Carcinoma|BRAF-Mutated Melanoma
Interventions: DRUG: TP-0903
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioenergetic Effect of Pioglitazone in CLD-PH
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Hypertension|Pulmonary Hypertension Due to Lung Diseases
Interventions: DRUG: Pioglitazone 30mg|DRUG: Placebo|DIAGNOSTIC_TEST: Labs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I, Multicenter, Open-label, Dose-escalation Study to Assess the Safety of Lenalidomide in Patients With Advanced Adult T-cell Leukemia-lymphoma and Peripheral T-cell Lymphomaperipheral T-cell Lymphoma
Status: COMPLETED
Conditions: Adult T-cell Leukemia-Lymphoma|Peripheral T-cell Lymphoma
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glaucoma Exercise as Medicine Study (GEMS).
Status: NOT_YET_RECRUITING
Conditions: Glaucoma
Interventions: BEHAVIORAL: Exercise, Bike exercise and muscle strength exercise.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Methotrexate or Pentostatin for Graft-versus-host Disease Prophylaxis in Risk-adapted Allogeneic Bone Marrow Transplantation for Hematologic Malignancies
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Acute Myelocytic Leukemia|Chronic Myelocytic Leukemia|Hodgkin's Disease|Myelodysplastic Syndrome
Interventions: DRUG: Methotrexate|DRUG: Pentostatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief Alcohol Interventions With Mobile Phone Applications for University Students: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Problematic Alcohol Use
Interventions: BEHAVIORAL: Promillekoll|BEHAVIORAL: PartyPlanner
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GA vs. CS for Endovascular Stroke Therapy
Status: UNKNOWN
Conditions: Stroke|Endovascular Repair|Anesthesia
Interventions: DRUG: General Anesthesia|DRUG: Conscious Sedation with Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Approach to Hiatal Hernia Repair Based on Collagen Study
Status: COMPLETED
Conditions: Hiatal Hernia|Gastroesophageal Reflux Disease
Interventions: PROCEDURE: Laparoscopic hiatal hernia repair with ProGrip™ mesh|PROCEDURE: Laparoscopic primary posterior crural repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Feasibility Trial of AccuCath 2.25" Blood Control (BC) Placed in Difficult Access Patients in the Emergency Department
Status: COMPLETED
Conditions: Vascular Access Complication
Interventions: DEVICE: AccuCath 2.25" BC Intravascular Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor Natural Killer Cells and Donor Stem Cell Transplant in Treating Patients With High Risk Myeloid Malignancies
Status: COMPLETED
Conditions: Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Acute Erythroid Leukemia|Acute Megakaryoblastic Leukemia|Acute Myeloid Leukemia|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Acute Myeloid Leukemia in Remission|Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Blasts Under 20 Percent of Bone Marrow Nucleated Cells|Blasts Under 20 Percent of Peripheral Blood White Cells|Chronic Myelomonocytic Leukemia|High Risk Myelodysplastic Syndrome|Myelodysplastic Syndrome|Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Therapy-Related Acute Myeloid Leukemia|Therapy-Related Myelodysplastic Syndrome
Interventions: BIOLOGICAL: Aldesleukin|BIOLOGICAL: Allogeneic CD56-positive CD3-negative Natural Killer Cells|PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Busulfan|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Peripheral Blood Stem Cell Transplantation|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parasite Clearance and Protection From Infection (PCPI) in Zambia
Status: RECRUITING
Conditions: Malaria
Interventions: DRUG: SP (Macleods Pharmaceuticals Ltd)|DRUG: AS (Guilin Pharmaceuticals)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Abiraterone Acetate in Asymptomatic or Mildly Symptomatic Patients With Metastatic Castration-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Abiraterone acetate|DRUG: Placebo|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Establishing a Dose-response Relationship With Accelerated Transcranial Magnetic Stimulation
Status: RECRUITING
Conditions: Treatment Resistant Depression
Interventions: DEVICE: Active TBS-DLPFC|DEVICE: Sham TBS-DLPFC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Combination With Ibrutinib for Advanced, Refractory Colorectal Cancers
Status: COMPLETED
Conditions: Colon Cancer|Colorectal Cancer|Colorectal Carcinoma|Colon Disease
Interventions: DRUG: Pembrolizumab|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years)
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Dexamethasona, Idarubicine, ARA-C, Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Methadone for Postoperative Pain Control After Thoracic Surgery
Status: TERMINATED
Conditions: Postoperative Pain
Interventions: DRUG: Methadone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate OP-101 (Dendrimer N-acetyl-cysteine) in Severe Coronavirus Disease 2019 (COVID-19) Patients
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: OP-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Working Through Outreach, Navigation and Digital Enabled Referral and Recruitment Strategies (ACT WONDER²S)
Status: NOT_YET_RECRUITING
Conditions: Cancer
Interventions: BEHAVIORAL: Continuing Medical Education Events (CME)|BEHAVIORAL: Trial Connect Portal|BEHAVIORAL: Clinical Trial Newsletters|BEHAVIORAL: Implicit Bias Training|BEHAVIORAL: Recruitment Dashboard|BEHAVIORAL: Portfolio Profiler|BEHAVIORAL: Eligibility Calculator|BEHAVIORAL: Clinical Trial Education Sessions (Community Residents Only)|BEHAVIORAL: ACT WONDER²S Phone-line/Email (Community Residents and Moffitt Patients)|BEHAVIORAL: New Patient Information (Moffitt Patients Only)|OTHER: No Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Evaluation of Outcomes Following Wavefront Optimized or Wavefront Guided Lasik Procedure in Low to Moderate Myopic Patients
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: WAVEFRONT Optimized LASIK|DEVICE: WAVEFRONT GUIDED LASIK
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Single-center Observational Clinical Trial of Stereotactic Radiotherapy on Metastatic Spinal Tumors Using TomoTherapy
Status: NOT_YET_RECRUITING
Conditions: Spinal Bone Metastases|Radiation Therapy
Interventions: RADIATION: Stereotactic body radiotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SPEARHEAD 2 Study in Subjects With Recurrent or Metastatic Head and Neck Cancer
Status: WITHDRAWN
Conditions: Head and Neck Cancer
Interventions: GENETIC: ADP-A2M4 in combination with pembrolizumab.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parent Acceptance and Commitment Therapy (PACT) for Parents of Children With Pediatric Feeding Disorder
Status: ACTIVE_NOT_RECRUITING
Conditions: Pediatric Feeding Disorder, Chronic|Pediatric Feeding Dysfunction, Acute
Interventions: BEHAVIORAL: Parent Acceptance and Commitment Therapy (PACT)|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Yoga Practice in Multiple Sclerosis Patients: a Multidimensional Approach
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Iyengar Yoga|BEHAVIORAL: Yoga app
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: REPLACE: Can Exercise Replace Inhaled Corticosteroid Treatment in Asthma? A RCT
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: High Intensity Interval Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing GDC 695 and Diclofenac Sodium Gel, 3% in Subjects With Actinic Keratoses
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: GDC 695|DRUG: Diclofenac Sodium Gel, 3%|DRUG: Vehicle gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Palonosetron, Ondansetron and Dexamethasone in the Prevention of Postoperative Nausea and Vomiting
Status: UNKNOWN
Conditions: Laparoscopic Surgery|Pediatrics|Nausea and Vomiting, Postoperative|Antiemetics|Therapeutic Use
Interventions: DRUG: Ondansetron+Dexamethasone|DRUG: Palonosetron+Dexamethasone|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Control of Hypertension by Non-Pharmacologic Means
Status: COMPLETED
Conditions: Cardiovascular Diseases|Heart Diseases|Hypertension|Vascular Diseases
Interventions: BEHAVIORAL: diet, sodium-restricted|BEHAVIORAL: diet, reducing|BEHAVIORAL: alcohol restriction|DRUG: antihypertensive agents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Montelukast Sodium Oral Thin Film and Chewable Tablet in Fasted Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Montelukast sodium oral thin films without water (A)|DRUG: Montelukast sodium oral thin films with water (B)|DRUG: Montelukast sodium chewable tablets with water (C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Longitudinal, Multi-Center Safety Study of Autologous Adult Adipose-Derived Regenerative Cell Injection Into Chronic Partial-Thickness Rotator Cuff Tears
Status: ENROLLING_BY_INVITATION
Conditions: Partial Thickness Rotator Cuff Tear
Interventions: DEVICE: Adipose Derived Regenerative Cells|DEVICE: Corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Volitional Pursed-lips Breathing
Status: COMPLETED
Conditions: COPD
Interventions: OTHER: Baseline|OTHER: MESH-Resistor 5|OTHER: MESH-Resistor 10|OTHER: Perforated Resistor 7|OTHER: Perforated Resistor 11
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improved Modified Care Meals to Improving the Quality Of Life of the Pre-Frailty Chewing Disorders of the Older Adult
Status: RECRUITING
Conditions: Food Selection|Quality of Life|Chewing Disease|Satisfaction
Interventions: OTHER: Texture Modified Foods Manual for chewing dysfunctions in older adult
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Opevesostat (MK-5684) in China Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (MK-5684-001)
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostatic Neoplasms|Metastatic Castration-Resistant Prostate Cancer
Interventions: DRUG: Opevesostat|DRUG: Dexamethasone|DRUG: Fludrocortisone|DRUG: Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zinc and Bone Turnover Study in Adolescent Females
Status: COMPLETED
Conditions: Bone|Growth|Osteoporosis
Interventions: DIETARY_SUPPLEMENT: Zinc Sulfate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cisplatin in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer or Lung Metastasis
Status: COMPLETED
Conditions: Metastatic Malignant Neoplasm in the Lung|Stage IIIB Non-Small Cell Lung Cancer|Stage IV Adult Soft Tissue Sarcoma|Stage IV Non-Small Cell Lung Cancer
Interventions: DRUG: Cisplatin|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing the Duration of Untreated Psychosis in the United States: The Impact of Screening and Systematic Communication
Status: ENROLLING_BY_INVITATION
Conditions: First Episode Psychosis (FEP)|Clinical High Risk for Psychosis (CHR)
Interventions: BEHAVIORAL: Screening Method (SM)|BEHAVIORAL: Screening and Communication Method (SCM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bioequivalence of Two Commercial Amoxicillin Suspensions
Status: COMPLETED
Conditions: Bioequivalence of Amoxicillin
Interventions: DRUG: amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Intrathecal SHP611 in Children With Metachromatic Leukodystrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: Metachromatic Leukodystrophy (MLD)
Interventions: DRUG: SHP611
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Inituomab, Pyrrolidone and Nab-paclitaxel for HER2+Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Intuzumab, pyrrolidone, nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Recovery Strategies at Work, Based on Mindfulness and Physical Exercise, on Levels of Job Stress
Status: COMPLETED
Conditions: Mental Health Wellness
Interventions: BEHAVIORAL: Mindfulness-based intervention|BEHAVIORAL: Physical exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erythropoietin and Pediatric Cardiac Surgery
Status: TERMINATED
Conditions: Congenital Heart Defect
Interventions: DRUG: acyanotic erythropoietin|DRUG: acyanotic placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Cetuximab and Bevacizumab in Cancer of the Esophagus After Failure of Patient's First Therapy
Status: WITHDRAWN
Conditions: Esophageal Carcinoma
Interventions: DRUG: Bevacizumab, cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Hamstring Stretching According to the Neural or Muscle Tissue Involvement
Status: COMPLETED
Conditions: Muscle Stretching
Interventions: OTHER: Straight-leg-raise (SLR)|OTHER: Passive Knee extension test (PKE)|OTHER: Maximum hip flexion (MHF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anecortave Acetate Risk-Reduction Trial (AART)
Status: TERMINATED
Conditions: Dry AMD
Interventions: DRUG: Anecortave Acetate (AL-3789) sterile suspension, 15 mg or 30 mg|OTHER: Anecortave Acetate Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Copanlisib and Nivolumab in Treating Patients With Richter's Transformation or Transformed Indolent Non-Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Diffuse Large B-Cell Lymphoma|Follicular Lymphoma|Indolent Non-Hodgkin Lymphoma|Lymphoplasmacytic Lymphoma|Marginal Zone Lymphoma|Richter Syndrome
Interventions: DRUG: Copanlisib|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Non-invasive Ventilation During Surgical Procedure in Rhythmology
Status: COMPLETED
Conditions: Cardiac Electrophysiology|Anesthesia|Acute Respiratory Failure
Interventions: OTHER: non invasive ventilation|OTHER: Standard oxygen therapy with facial mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Comparing Patient Function and Satisfaction With Arthroscopic Subacromial Decompression Before and After Repair of Complete Rotator Cuff Tears
Status: UNKNOWN
Conditions: Rotator Cuff Tear|Acromial Spur
Interventions: PROCEDURE: Rotator Cuff Repair and Subacromial Decompression|OTHER: Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Effects of Pulse Consumption on Biomarkers in Adults With Type 2 Diabetes or Met Syn
Status: COMPLETED
Conditions: Type2 Diabetes Mellitus|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Glucola|DIETARY_SUPPLEMENT: Whole pea meal|DIETARY_SUPPLEMENT: Pea flour meal|DIETARY_SUPPLEMENT: Whole lentils|DIETARY_SUPPLEMENT: Lentil flour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Memantine and Intensive Speech-Language Therapy in Aphasia
Status: COMPLETED
Conditions: Aphasia|Stroke
Interventions: DRUG: memantine|BEHAVIORAL: constraint-induced language therapy (CIAT)|DRUG: memantine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Cold Spray and Ice Applied During Intravenous Access on Pain and Fear i in Pediatric Emergency Unit
Status: COMPLETED
Conditions: Children, Only|Pain|Emergencies
Interventions: OTHER: Cold spray|OTHER: Refrigerated gel ice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety for 24 Weeks Intake of Korean Red Ginseng in Adults
Status: COMPLETED
Conditions: Healthy|Diabetes|Hypertension|Hyperlipidemia
Interventions: DIETARY_SUPPLEMENT: Korean Red Ginseng|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Barley and Oat Breads on Appetite
Status: COMPLETED
Conditions: Healthy|Appetitive Behavior
Interventions: OTHER: White Bread|OTHER: Whole Wheat Bread|OTHER: Barley Bread|OTHER: Oat Bread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Safety, Tolerability and Pharmacokinetics of SBC-102 (Sebelipase Alfa) in Adult Participants With Lysosomal Acid Lipase Deficiency
Status: COMPLETED
Conditions: Cholesterol Ester Storage Disease(CESD)|Lysosomal Acid Lipase Deficiency|LAL-Deficiency
Interventions: DRUG: Sebelipase alfa 0.35 mg/kg|DRUG: Sebelipase alfa 1 mg/kg|DRUG: Sebelipase alfa 3 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fascial Manipulation on the Treatment of Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: PROCEDURE: Fascial Manipulation|PROCEDURE: Sham Fascial Manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of Radium Therapy (Radium-223 Dichloride) to the Usual Chemotherapy Treatment (Paclitaxel) for Advanced Breast Cancer That Has Spread to the Bones
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic HER2-Negative Breast Carcinoma|Metastatic Malignant Neoplasm in the Bone
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|OTHER: Electronic Health Record Review|PROCEDURE: Magnetic Resonance Imaging|DRUG: Paclitaxel|RADIATION: Radium Ra 223 Dichloride|PROCEDURE: Single Photon Emission Computed Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Plate Size on Food Consumption and Satiety
Status: UNKNOWN
Conditions: Satiety|Food Consumption
Interventions: BEHAVIORAL: Food consumption using plates with a diameter of 23 cm.|BEHAVIORAL: Washout period|BEHAVIORAL: Food consumption using plates with a diameter of 31 cm.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Promoting Asylum-seeking and Refugee Children's Coping With Trauma
Status: COMPLETED
Conditions: Mental Health Disorder|Post-Traumatic Stress Disorder in Adolescence|Depression|Social Anxiety
Interventions: BEHAVIORAL: Teaching Recovery Techniques, TRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drain-Less Abdominally Based Breast Reconstruction Using Lysine-Derived Urethane Adhesive
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DEVICE: Tissue Glu|DEVICE: Drain|OTHER: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of DSLT and SLT on the Corneal Endothelium: A GLAUrious Trial Sub-Study
Status: COMPLETED
Conditions: Open Angle Glaucoma
Interventions: DEVICE: Direct Selective Laser Trabeculoplasty (DSLT)|DEVICE: Selective Laser Trabeculoplasty (SLT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetics of Two Different Persantin® Sugar Coated Tablets in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Persantin® new formulation|DRUG: Persantin® commercial formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vorinostat With or Without Bortezomib in Treating Patients With Refractory or Recurrent Stage IIB, Stage III, or Stage IV Cutaneous T-Cell Lymphoma
Status: WITHDRAWN
Conditions: Lymphoma
Interventions: DRUG: bortezomib|DRUG: vorinostat|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Etigilimab and Nivolumab in Subjects With Locally Advanced or Metastatic Tumors.
Status: COMPLETED
Conditions: Solid Tumor, Adult|Advanced Solid Tumor|Metastatic Solid Tumor
Interventions: DRUG: Etigilimab dosing|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: add-on Low Dose Memantine in Middle-to-old Aged Bipolar II Disorder Patients
Status: UNKNOWN
Conditions: Bipolar II Disorder
Interventions: DRUG: Memantine or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nasal Prep for Nasendoscopy in Children
Status: COMPLETED
Conditions: Flexible Nasendoscopy
Interventions: DRUG: 0.05% xylometazoline hydrochloride with 1% lidocaine hydrochloride|DRUG: 0.05% xylometazoline hydrochloride|DRUG: Isotonic normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Hutchison MediPharma Limited(HMPL)-523 in Patients With Relapsed or Refractory Mature B-cell Neoplasms
Status: COMPLETED
Conditions: Mature B-cell Neoplasms
Interventions: DRUG: HMPL-523
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT