pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparing Efficacy and Safety Between Pertuzumab® and Perjeta® in Neoadjuvant Treatment of HER2+ Breast Cancer
Status: COMPLETED
Conditions: HER2-positive Breast Cancer
Interventions: DRUG: Trastuzumab|DRUG: Pertuzumab|DRUG: Carboplatin|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sleep Apnea in Head and Neck Cancer Patients at the University of Colorado
Status: WITHDRAWN
Conditions: Obstructive Sleep Apnea|Squamous Cell Carcinoma of Head and Neck
Interventions: DIAGNOSTIC_TEST: Obstructive sleep apnea testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Effects of Efalizumab on Immune Responses in Subjects With Moderate Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Raptiva (efalizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Compression Hosiery to Avoid Post-Thrombotic Syndrome
Status: TERMINATED
Conditions: Deep Vein Thrombosis|Deep Vein Thrombosis Leg|Post Thrombotic Syndrome
Interventions: DEVICE: Graduated compression stocking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Use of Thymoglobulin, Sirolimus, and Donor Bone Marrow With Kidney Transplantation Patients
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: Allogeneic Bone Marrow, Anti-Thymocyte Globulin (Sangstat) & Sirolimus (Wyeth-Ay
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Regional Anesthesia in Breast Surgery
Status: COMPLETED
Conditions: Breast Neoplasms|Pain|Analgesia|Regional Anesthesia
Interventions: PROCEDURE: Regional anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Caval-aorta Index and Perfusion Index on Predict Hypotension After Spinal Anaesthesia in Elderly
Status: RECRUITING
Conditions: Anesthesia, Spinal
Interventions: DEVICE: ultrasonography to measure the index of the caval aorta and non-invasive pulse oximetry for perfusion index
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparing Press and Filiform Needle Acupuncture Effectiveness for Improving Insomnia in COVID-19 Healthcare Workers
Status: COMPLETED
Conditions: Insomnia
Interventions: PROCEDURE: Press needles|PROCEDURE: Filiform Needles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Surgical Technique on PDC
Status: ACTIVE_NOT_RECRUITING
Conditions: Embedded and Impacted Teeth
Interventions: PROCEDURE: Open Surgical Exposure Technique|PROCEDURE: Closed Surgical Exposure Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block Versus Classic Epidural Analgesia in Labor
Status: UNKNOWN
Conditions: Analgesia in Labor
Interventions: PROCEDURE: ESP Block With Bupivacain|PROCEDURE: Epidural Analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Calisthenic Exercise Training Combined With Aerobic Exercise in Patients With Dyslipidemia
Status: RECRUITING
Conditions: Dyslipidemias
Interventions: OTHER: Calisthenic Exercises|OTHER: Aerobic Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Segmentectomy and Lobectomy in Small (2 cm or Less 0.5<CTR<1) Non-small Cell Lung Cancer: a Prospective, Multicenter Randomized Controlled Study
Status: ENROLLING_BY_INVITATION
Conditions: NSCLC, Stage I
Interventions: PROCEDURE: Segmentectomy|PROCEDURE: Lobectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2, Randomized, Double Blind, Placebo Controlled Multicenter Study of Autologous MSC-NTF Cells in Patients With ALS
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis (ALS)
Interventions: BIOLOGICAL: Nurown MSC-NTF cells|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Atezolizumab Combined With Platinum-based Chemotherapy as Neoadjuvant Therapy for Patients With Resectable Stage II-IIIB
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel-Coated Balloon Versus Zotarolimus-Eluting Stent for Treatment of De Novo Coronary Artery Lesions
Status: ACTIVE_NOT_RECRUITING
Conditions: De Novo Stenosis|Coronary Artery Disease|Percutaneous Coronary Intervention
Interventions: DEVICE: Lepu Paclitaxel coated balloon|DEVICE: Resolute Integrity Zotarolimus eluting stents|DRUG: Aspirin|DRUG: Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Pneumoperitoneum and Neuromuscular Block on Renal Function in Diabetes Patients
Status: UNKNOWN
Conditions: Diabetes Mellitus|Acute Kidney Injury|Laparoscopic Surgical Procedure|Neuromuscular Blockade
Interventions: PROCEDURE: high pressure|DRUG: deep neuromuscular block|PROCEDURE: low pressure|DRUG: moderate neuromuscular block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Linagliptin + Metformin vs Metformin Alone in Patients With Prediabetes
Status: COMPLETED
Conditions: Prediabetic State|Insulin Resistance
Interventions: COMBINATION_PRODUCT: Linagliptin + metformin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate AZP531 in Healthy Volunteers, Overweight/Obese Volunteers and Patients With Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: AZP-531|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blood Flow Restriction Training After Patellar INStability
Status: RECRUITING
Conditions: Patellar Dislocation|Knee Injuries|Leg Injury|Wounds and Injuries
Interventions: DEVICE: Blood Flow Restriction Training|DEVICE: Sham Blood Flow Restriction Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Controlled Investigation to Evaluate Impact of dCBT on Psychological Symptom Burden in Adult Subjects With PF
Status: ACTIVE_NOT_RECRUITING
Conditions: Generalized Anxiety Disorder|Pulmonary Fibrosis
Interventions: DEVICE: Digital cognitive behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deep Brain Stimulation for Autonomic and Gait Symptoms in Multiple System Atrophy
Status: COMPLETED
Conditions: Multiple System Atrophy|Autonomic Failure|Postural Hypotension|Bladder, Neurogenic|Gait Disorders, Neurologic
Interventions: PROCEDURE: Deep brain stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BreAst Cancer and Cardiotoxicity Induced by RAdioTherapy: the BACCARAT Study
Status: COMPLETED
Conditions: Breast Cancer|Cardiac Toxicity
Interventions: OTHER: Subclinical cardiac lesions and biomarkers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Pharmacokinetic Study of ENVARSUS in Adult De-novo Kidney Transplant Patients
Status: COMPLETED
Conditions: Organ or Tissue Transplant; Complications
Interventions: DRUG: ENVARSUS®|DRUG: ADVAGRAF®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Vildagliptin Compared to Placebo in Patients With Type 2 Diabetes and Mild Hyperglycemia
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: vildagliptin|DRUG: Vildagliptin Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Exercise Trial for Wheelchair Users
Status: COMPLETED
Conditions: Spinal Cord Injury|Multiple Sclerosis|Muscular Dystrophy|Cerebral Palsy|Spina Bifida|Amputation|Arthritis|Stroke
Interventions: OTHER: Educational session to promote physical activity|OTHER: Minimal contact
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy of Luteinizing Hormone (LH) Activity in Low Responder Patients With Transdermal Testosterone
Status: UNKNOWN
Conditions: Other Complications Associated With Artificial Fertilization
Interventions: DRUG: Testosterone and FSHr-LHr|DRUG: testosterone and FSHr alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Motivational Interviewing Tailored Programme for Promoting Advance Care Planning Behaviours
Status: COMPLETED
Conditions: End Stage Disease
Interventions: BEHAVIORAL: Motivational Interviewing tailored Advance Care Planning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study on the Significance of Joint Evaluation of Gastrointestinal Ultrasound Results and Renal Artery Resistance Index for Assessing the Intestinal-renal Syndrome in Sepsis Patients
Status: RECRUITING
Conditions: Superior Mesenteric Artery Resistance Index|Renal Artery Resistance Index
Interventions: DIAGNOSTIC_TEST: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Early Diagnosis of the GLUT1 Deficiency Syndrome With a Blood Based Test
Status: COMPLETED
Conditions: Glut1 Deficiency Syndrome|De Vivo Disease|Seizures|Movement Disorders|Intellectual Disability|Ataxia
Interventions: DIAGNOSTIC_TEST: METAglut1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Mitigation Treatments on Bruising of CCH-aaes Treatment of Buttock Cellulite
Status: COMPLETED
Conditions: Edematous Fibrosclerotic Panniculopathy (EFP)|Cellulite
Interventions: DRUG: CCH-aaes|OTHER: Compression|OTHER: Cold Packs|DRUG: Arnica Gel|DRUG: INhance®|OTHER: PDL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase I, Open-Label, Multicentre Study to Evaluate the Safety, Tolerability and Pharmacokinetics of MEDI4736 in Patients With Advanced Solid Tumours
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: MEDI4736|DRUG: tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Family Intervention for Black Teens With Type 1 Diabetes
Status: RECRUITING
Conditions: Type 1 Diabetes|Family Relations
Interventions: BEHAVIORAL: The 3Ms 2.0 Intervention|BEHAVIORAL: Educational Attention Control (EAC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of ONTAK (Denileukin Diftitox) in Previously Treated Cutaneous T-Cell Lymphoma Patients
Status: COMPLETED
Conditions: Lymphoma, T-Cell, Cutaneous|Mycosis Fungoides|Sezary Syndrome
Interventions: DRUG: ONTAK
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testosterone in Metastatic Renal Cell Carcinoma Patients
Status: COMPLETED
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: Testosterone undecanoate and sunitinib or pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV)
Status: COMPLETED
Conditions: Respiratory Insufficiency of Prematurity
Interventions: DEVICE: nCPAP|DEVICE: NIPPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety of and Immune Response to a Human Parainfluenza Virus Vaccine (rHPIV3cp45) in Healthy Infants
Status: COMPLETED
Conditions: Paramyxoviridae Infections|Virus Diseases
Interventions: BIOLOGICAL: rHPIV3cp45|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Adaptive Music Therapy for Psychosocial and Cognitive Functions of Older Adults
Status: RECRUITING
Conditions: Stress, Psychological|Executive Functions|Loneliness|Emotion Regulation|Functional Abilities|Well Being
Interventions: OTHER: Adaptive Music Intervention|OTHER: Traditional Music Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Optimal Method of Pain Management in Patients With Multiple Rib Fractures
Status: UNKNOWN
Conditions: 3 or More Rib Fractures
Interventions: PROCEDURE: ON-Q® Pain Relief System|PROCEDURE: Thoracic epidural catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Intravenous TAD® 600 mg/4 mL Solution for Injection to Evaluate Efficacy and Safety in Preventing Myocardial Injury in Patients With Pneumonia.
Status: RECRUITING
Conditions: Pneumonia|Myocardial Injury
Interventions: DRUG: TAD® 600 mg/4 mL powder and solvent for solution for injection|DRUG: Saline solution 0.9% of sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: EASE Trial: Exhale Airway Stents for Emphysema
Status: UNKNOWN
Conditions: Emphysema
Interventions: DEVICE: Exhale® Drug-Eluting Stent|DEVICE: Sham control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telemedicine Program in Parkinson's Disease (TELEPARK)
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: OTHER: Comprehensive evaluation|OTHER: Physical Intervention at home|OTHER: Home-Based telemedicine program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Randomized Controlled Trial of the Effectiveness of Perineal Pain and Security of the Suture Led by the Result of Hemostasis Versus Manual Compression Routine Suture Perineal Tears of First Degree During Childbirth
Status: COMPLETED
Conditions: Parturition|Delivery, Obstetric
Interventions: PROCEDURE: Suture of perineum|PROCEDURE: hemostatis by digital compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3015014 in Healthy Participants With Elevated Low Density Lipoprotein Cholesterol
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DRUG: LY3015014 IV|DRUG: Placebo IV|DRUG: LY3015014 SC|DRUG: Placebo SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Stimulation of Gastric Slow Waves With Acupuncture at St36 and Pe6 - a Randomized Single-blind Controlled Trial
Status: COMPLETED
Conditions: Acupuncture
Interventions: PROCEDURE: verum acupuncture|PROCEDURE: sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Correction of Farsightedness in Children Study
Status: COMPLETED
Conditions: Hyperopia|Farsightedness
Interventions: DEVICE: Spectacles|DEVICE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Doxorubicin and Cisplatin With or Without Paclitaxel in Treating Patients With Locally Advanced, Metastatic, and/or Relapsed Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Cancer
Interventions: DRUG: cisplatin|DRUG: doxorubicin hydrochloride|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study of ISB 1442 in Relapsed/Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Relapsed/Refractory Multiple Myeloma
Interventions: DRUG: ISB 1442 SC injection escalating doses|DRUG: ISB 1442 SC injection at RP2D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Physical Activity and Joint Health in Severe Haemophilia A Patients ≥12 Years Treated Once Weekly With Efanesoctocog Alfa
Status: ACTIVE_NOT_RECRUITING
Conditions: Hemophilia A, Severe
Interventions: DRUG: Efanesoctocog alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Mesh Integration and Mesh Contraction After Open Preperitoneal Inguinal Hernia Repair Using a Memory Ring Containing Device
Status: COMPLETED
Conditions: Unilateral Inguinal Hernia
Interventions: DEVICE: Rebound HRD Mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin E Treatment for Long-Chain 3-Hydroxyacyl Coenzyme A (CoA) Dehydrogenase (LCHAD) Associated Neuropathy
Status: TERMINATED
Conditions: Peripheral Neuropathy|Mitochondrial Trifunctional Protein Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin E supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of an Autologous Microbiome Transplant in Adult Atopic Dermatitis Patients
Status: COMPLETED
Conditions: Atopic Dermatitis Eczema
Interventions: BIOLOGICAL: Autologous Microbial Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acid Production in Dental Plaque After Exposure to Probiotic Bacteria
Status: COMPLETED
Conditions: Caries
Interventions: DIETARY_SUPPLEMENT: Probiotic Lactobacilli reuteri|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence Study of Two Formulations of 10 mg Lisinopril Tablet Under Fasting Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lisinopril 10 mg tablets of PT Dexa Medica|DRUG: Lisinopril 10 mg tablets of PT Boehringer Ingelheim Indonesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Tolvaptan vs Fluid Restriction in Hospitalized Subjects With Dilutional Hyponatremia
Status: TERMINATED
Conditions: Hyponatremia|Dilutional Hyponatremia|Inappropriate ADH Syndrome
Interventions: DRUG: tolvaptan|OTHER: Fluid Restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Focused Shock Waves Combined With Adjuvant Therapy With Tendon Supplement
Status: COMPLETED
Conditions: Fasciitis, Plantar
Interventions: DIETARY_SUPPLEMENT: Tendisulfur Pro|DEVICE: Focused shock wave
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of mHealth Post-discharge Intervention for Patients With Severe Mental Illness
Status: ENROLLING_BY_INVITATION
Conditions: Bipolar Disorder|Major Depression|Schizophrenia
Interventions: BEHAVIORAL: Transition-FOCUS mHealth Intervention|BEHAVIORAL: Check-In
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Chinese Prescription Weiqi Decoction on Chronic Atrophic Gastritis
Status: COMPLETED
Conditions: Gastritis
Interventions: DRUG: Weiqi decotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ALXN1840 (Coated and Non-coated) Administered With And Without Omeprazole In Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ALXN1840 Enteric-coated Tablet|DRUG: ALXN1840 Non-coated Capsule|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Open Label Continuation Study of TRC105 for Patients Who Have Completed a Prior TRC105 Trial
Status: NO_LONGER_AVAILABLE
Conditions: Solid Tumors
Interventions: DRUG: TRC105|DRUG: Bevacizumab|DRUG: Axitinib|DRUG: Pazopanib|DRUG: Capecitabine
Study Type: EXPANDED_ACCESS
Clinical trial: Effect of BrainPhyt, a Microalgae Based Ingredient on Cognitive Function in Healthy Older Subjects
Status: COMPLETED
Conditions: Healthy Aging|Dietary Supplement|Fucoxanthin|Cognitive Impairment|Neuroprotection|Mood|Stress|Sleep
Interventions: DIETARY_SUPPLEMENT: BrainPhyt|DIETARY_SUPPLEMENT: 100 % Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Medial Flap Coblation Turbinoplasty Versus Submucous Resection
Status: COMPLETED
Conditions: Inferior Turbinate Hypertrophy
Interventions: PROCEDURE: Medial Flap Coblation Turbinoplasty|PROCEDURE: Submucous Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Driver Ablation of Persistent Atrial Fibrillation With Severe Atrial Fibrosis.
Status: NOT_YET_RECRUITING
Conditions: Persistent Atrial Fibrillation
Interventions: PROCEDURE: Circumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + driver ablation|PROCEDURE: Circumferential pulmonary vein isolation + linear ablation + posterior wall box isolation|PROCEDURE: Circumferential pulmonary vein isolation + linear ablation + vein of Marshall ethanol infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Ertapenem Versus Another Antibiotic in the Treatment of Diabetic Foot Infections in Adults (0826-034)
Status: COMPLETED
Conditions: Foot Infections in Diabetic Patients
Interventions: DRUG: MK0826, ertapenem sodium / Duration of Treatment - 24 weeks|DRUG: Comparator: Piperacillin/Tazobactam / Duration of Treatment - 24 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Orthostatic Hypotension in Children With Acute Febrile Illness
Status: UNKNOWN
Conditions: Fever|Orthostatic Hypotension
Interventions: PROCEDURE: All subjects will have their blood pressure measured in supine position (after 5 minute of rest) and after 3 minute of standing.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized Clinical Trial Evaluating the Efficacy of Topical Imiquimod in High Grade Cervical Intraepithelial Lesions
Status: COMPLETED
Conditions: High Grade Intraepithelial Neoplasia|Cervix Cancer
Interventions: PROCEDURE: Control|DRUG: Imiquimod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of a Biodegradable Balloon for the Treatment of Prostate Cancer by Intensity Modulated Radiotherapy (BioPro-RCMI)
Status: SUSPENDED
Conditions: Prostate Cancer
Interventions: DEVICE: Biodegradable balloon implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3D Ballistocardiography in Microgravity
Status: UNKNOWN
Conditions: Healthy
Interventions: OTHER: Parabolic flight|OTHER: Cardiovascular parameters measurements|DEVICE: 3D-BCG sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prevention of Renal Complications of Diabetes With Thiamine
Status: UNKNOWN
Conditions: Diabetic Nephropathy
Interventions: DIETARY_SUPPLEMENT: Thiamine 300mg PO once daily|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MR-spectroscopy in Post-covid Condition Prior to and Following a Yoga Breathing Intervention
Status: RECRUITING
Conditions: Post COVID-19 Condition|Somatic Symptom Disorder
Interventions: BEHAVIORAL: yoga|BEHAVIORAL: social contact
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: First in Human Study of EI-001 Monoclonal Antibody in Healthy Volunteers
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: EI-001|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide in HIV-1 Infected Adolescents
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: E/C/F/TAF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanistic Effects of Colchicine in Patients With Myocardial Infarction
Status: WITHDRAWN
Conditions: Myocardial Infarction
Interventions: DRUG: Colchicine 0.6 mg tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Norovirus GI.1/GII.4 Bivalent Virus-Like Particle (VLP) Vaccine in Children
Status: COMPLETED
Conditions: Norovirus
Interventions: BIOLOGICAL: GI.1/GII.4 (15/15)|BIOLOGICAL: GI.1/GII.4 (15/50)|BIOLOGICAL: GI.1/GII.4 (50/50)|BIOLOGICAL: GI.1/GII.4 (50/150)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MS Study Evaluating Safety and Efficacy of Two Doses of Fingolimod Versus Copaxone
Status: TERMINATED
Conditions: Relapsing-remitting Multiple Sclerosis (RRMS)
Interventions: DRUG: fingolimod|DRUG: glatiramer acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-thyroidectomy Vocal Cord Paralysis Along With Hypocalcemia: STROBE - Guided Prospective Cohort
Status: UNKNOWN
Conditions: Iatrogenic Hypocalcemia|Iatrogenic Hypoparathyroidism|Vocal Cord Paralysis|Vocal Cord Paresis|Vocal Cord; Injury, Superficial|Thyroid Cancer, Papillary|Thyroid Cancer|Multinodular Goiter|Thyroid Neoplasms|Thyroid Nodule|Calcium Deficiency|PTH
Interventions: PROCEDURE: Total thyroidectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Does Flaxseed Supplementation Improve Glycemic Control in Individuals With Pre-diabetes?
Status: COMPLETED
Conditions: PreDiabetes
Interventions: DIETARY_SUPPLEMENT: Flaxseed High Dose|DIETARY_SUPPLEMENT: Flaxseed Low Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Randomized Trial On Radiation Dose Estimates Of CT Angiography In Patients Applying Iterative Image Reconstruction Techniques - The PROTECTION V Study -
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: RADIATION: Control group|RADIATION: Intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of NIDO-361 in Patients With SBMA
Status: RECRUITING
Conditions: Spinal and Bulbar Muscular Atrophy|Kennedy's Disease
Interventions: DRUG: NIDO-361|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Soy Isoflavone in Combination With Radiation Therapy and Cisplatin in SCC of the Head and Neck
Status: COMPLETED
Conditions: Cancer of Head and Neck
Interventions: DRUG: Soy isoflavone|RADIATION: Radiation|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Efficacy of EN001 in Patients With Charcot-Marie-Tooth Disease Type 1A
Status: RECRUITING
Conditions: Charcot-Marie-Tooth Disease Type 1A
Interventions: DRUG: EN001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Capsaicin Effect on Cytokines Profile in Dyslipidemia
Status: UNKNOWN
Conditions: Dyslipidemia|Overweight or Obesity
Interventions: DRUG: Capsaicin|DRUG: Magnesia calcinada
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial With Clobetasol and Dexamethasone for Topical Treatment of Oral Lesions of Chronic Graft-versus-host Disease
Status: COMPLETED
Conditions: Graft vs Host Disease|Oral Manifestations
Interventions: DRUG: Clobetasol|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 12-week Study to Compare the Efficacy and Safety of Fixed Combinations of Fenofibrate/Simvastatin 145/20mg and Fenofibrate/Simvastatin 145/40mg Tablets Versus Fenofibrate or Simvastatin Monotherapies in Subjects With Abnormal Blood Levels of Fats (Lipids) and at High Risk of Cardiovascular Disease
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: Fixed Combination of Fenofibrate/simvastatin 145/20 mg|DRUG: Simvastatin 20 mg|DRUG: Fenofibrate 145 mg|DRUG: Fixed Combination of Fenofibrate/simvastatin 145/40 mg|DRUG: Simvastatin 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Tetrahydrobiopterin (BH4) on Leg Blood Flow and Exercise Capacity in Patients With Peripheral Artery Disease
Status: WITHDRAWN
Conditions: Peripheral Artery Disease|Peripheral Arterial Disease
Interventions: DRUG: Sapropterin Dihydrochloride (BH4, tetrahydrobiopterin)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: En Bloc TURBT With Collins Loop vs Conventional TURBT
Status: UNKNOWN
Conditions: Bladder Cancer|Bladder Neoplasm|Bladder Urothelial Carcinoma|Bladder Cancer Stage|Urothelial Carcinoma Recurrent
Interventions: DEVICE: En bloc TURBT Collins Loop|DEVICE: Conventional TURBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Adjunctive Neurofeedback Training Program to Enhance Wellness Among Trauma-Exposed Postpartum Mothers
Status: RECRUITING
Conditions: Well-Being, Psychological|Dissociation|Maternal Care Patterns|Maternal Behavior|Maternal Distress|Mood Disturbance|Emotional Regulation|Post Traumatic Stress Disorder
Interventions: DEVICE: Neuroptimal (Zengar, Inc.) Neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: High-Dose Chemotherapy Given Together With Peripheral Blood Stem Cell Transplant in Treating Patients With Intestinal T-Cell Lymphoma
Status: UNKNOWN
Conditions: Lymphoma|Small Intestine Cancer
Interventions: DRUG: carmustine|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: doxorubicin hydrochloride|DRUG: epirubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: melphalan|DRUG: methotrexate|DRUG: prednisolone|DRUG: vincristine sulfate|PROCEDURE: autologous hematopoietic stem cell transplantation|PROCEDURE: biopsy|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of the Quotient® ADHD Assessment in a System of Care
Status: TERMINATED
Conditions: Attention Deficit and Disruptive Behavior Disorders|Attention Deficit Disorder With Hyperactivity
Interventions: DEVICE: Quotient®|BEHAVIORAL: Usual Clinic ADHD Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Comparison of MRI Perfusion and FDG PET/CT to Distinguish Between Radiation Injury and Tumor Progression
Status: COMPLETED
Conditions: Brain Cancer
Interventions: DIAGNOSTIC_TEST: MRI perfusion and PET/CT scans
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of BGG492 on EEG in Patients With Photosensitive Epilepsy
Status: COMPLETED
Conditions: Photosensitive Epilepsy
Interventions: DRUG: BGG492|DRUG: BGG492|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Root Canal Instruments on Removal of Endotoxins From Necrotic Root Canals
Status: COMPLETED
Conditions: Endodontic Disease
Interventions: OTHER: one shape|OTHER: protaper next
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Assess Immunegnicity & Safety of Pentavalent Meningococcal Vaccine (NmCV-5)
Status: COMPLETED
Conditions: Meningococcal Meningitis
Interventions: BIOLOGICAL: NmCV-5|BIOLOGICAL: Menactra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multi-level Approach of Brain Activity Using Intracranial Electrodes in Epileptic Patients
Status: NOT_YET_RECRUITING
Conditions: Focal Epilepsy|Electrodes, Implanted|Cognitive Function|Neurophysiology
Interventions: DEVICE: Intracranial macro-microelectrode recording
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bioavailability Study of Pregabalin Extended Release Formulation With Various Release Rates in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pregabalin ER|DRUG: Pregabalin ER|DRUG: Pregabalin ER|DRUG: Pregabalin ER|DRUG: Pregabalin ER|DRUG: Pregabalin ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Trial of Efficacy and Safety of Anaferon in the Treatment of Acute Respiratory Viral Infections
Status: COMPLETED
Conditions: Acute Respiratory Viral Infections
Interventions: DRUG: Anaferon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel, Carboplatin, and Gefitinib in Treating Patients With Advanced Non-Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: gefitinib|DRUG: paclitaxel|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IDH2 Inhibition Using Enasidenib as Maintenance Therapy for IDH2-mutant Myeloid Neoplasms Following Allogeneic Stem Cell Transplantation
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Chronic Myelomonocytic Leukemia
Interventions: DRUG: Enasidenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Pantoprazole Sodium Enteric-Coated Spheroid Suspension In Infants With Presumed GERD
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: pantoprazole sodium enteric-coated spheroid suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Partially Hydrolysed Protein Infant Formula on Trans-epidermal Water Loss (TEWL)
Status: RECRUITING
Conditions: Atopic Dermatitis|Skin Condition
Interventions: DIETARY_SUPPLEMENT: Intact Cow's Milk Protein Formula|DIETARY_SUPPLEMENT: Partially Hydrolysed Whey Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Tolerability of Lactoferrin/FOS in Very Low Birth Weight Infants
Status: UNKNOWN
Conditions: Safety Issues|Tolerance|Very Low Birth Weight Infant
Interventions: DIETARY_SUPPLEMENT: Lactoferrin/FOS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Dose Escalation of Oral BAY1161909 in Combination With Intravenous Paclitaxel
Status: TERMINATED
Conditions: Medical Oncology
Interventions: DRUG: BAY1161909|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of BIO-K+ CL1285® Prophylaxis in the Prevention of Traveler's Diarrhea in Adults
Status: COMPLETED
Conditions: Diarrhea
Interventions: OTHER: Probiotic: Bio-K+ CL1285|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Transcutaneous Electrical Nerve Stimulation for in the Treatment of Premature Ejaculation
Status: COMPLETED
Conditions: Transcutaneous Electrical Nerve Stimulation|Premature Ejaculation
Interventions: DEVICE: transcutaneous posterior tibial nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Intetumumab, Alone and in Combination With Dacarbazine, in Participants With Stage 4 Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Intetumumab|DRUG: Dacarbazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 12-Week Safety and Pharmacodynamic Study of AT1001 (Migalastat Hydrochloride) in Female Participants With Fabry Disease
Status: COMPLETED
Conditions: Fabry Disease
Interventions: DRUG: migalastat HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intergenerational Strengths-Based Program for American Indian Girls as They Transition to Adulthood
Status: COMPLETED
Conditions: Sexual Activity|Sex|Alcohol Use|Pregnancy|Drug Use
Interventions: BEHAVIORAL: Asdzaan Be'eena' Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Inpatient Diabetes Mellitus (DM) Management With Continuous Glucose Monitoring Devices, a Pilot Study.
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: Continuous glucose Monitoring (CGM) device and Point of Care (POC) blood glucose|OTHER: Point of Care (POC) blood glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cooling Plus Best Medical Treatment Versus Best Medical Treatment Alone for Acute Ischaemic Stroke
Status: TERMINATED
Conditions: Acute Ischemic Stroke
Interventions: DEVICE: Hypothermia|DRUG: Buspirone|DRUG: Pethidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study on the Efficacy and Safety of 2 Week or 3 Week Xelox Regimen for Adjuvant Chemotherapy in CRC
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Capecitabine Oral Tablet [Xeloda]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Coagulopathy in Cirrhotic Patients Undergoing Invasive Procedures
Status: UNKNOWN
Conditions: Liver Cirrhosis|Coagulopathy
Interventions: OTHER: Thromboelastography based protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oropharyngeal Dysphagia in Patients With COVID-19
Status: COMPLETED
Conditions: Oropharyngeal Dysphagia|COVID-19|Sars-CoV2|Nutrition
Interventions: DIAGNOSTIC_TEST: Swallowing evaluation with the EAT-10 and the volume-viscosity swallowing test (V-VST)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Essential Fatty Acids for Major Depression
Status: COMPLETED
Conditions: Major Depression
Interventions: DRUG: Eicosapentaenoic acid (EPA) 0.7 grams/day or 1.5 grams/day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Combination of the Best Supportive Care Plus E7080 Versus Best Supportive Care Alone, in Patients With Advanced Lung Cancer or Lung Cancer That Has Spread, Who Have Been Previously Treated, Unsuccessfully, With at Least 2 Different Treatments
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Lenvatinib|DRUG: Lenvatinib matched placebo|DRUG: BSC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of BI 409306 Tablets in Healthy Asian Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Placebo|DRUG: BI-409306 25 milligram (mg) SD|DRUG: BI-409306 50 mg SD|DRUG: BI-409306 100 mg SD|DRUG: BI-409306 100 mg MD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Developing an Intervention to Prevent Visceral Adipose Tissue Accumulation
Status: COMPLETED
Conditions: Menopause|Visceral Adipose Tissue Accumulation|Abdominal Obesity|Obesity|Overweight
Interventions: BEHAVIORAL: Multi-level intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Circulating Tumor Cells (CTC) Before and After Thoracic Resection With and Without Intraoperative Use of ExtraCorporeal Membrane Oxygenator(ECMO) or Cardio Pulmonary By Pass (CPB)
Status: RECRUITING
Conditions: Thoracic Surgery|Cardiopulmonary Bypass
Interventions: PROCEDURE: Resection with intraoperative use of ECMO/CPB|PROCEDURE: Resection without intraoperative use of ECMO/CPB
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of Bezafibrate in Patients With Primary Biliary Cirrhosis to Archive Complete Biochemical Response in Non-responders
Status: UNKNOWN
Conditions: Primary Biliary Cirrhosis
Interventions: DRUG: Bezafibrate|DRUG: Ursodeoxycholic Acid|DRUG: Placebo (for Bezafibrate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT