pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Tolerability of Azilsartan Medoxomil Plus Chlorthalidone Compared to Olmesartan Medoxomil Plus Hydrochlorothiazide in Participants With Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Azilsartan medoxomil and chlorthalidone|DRUG: Olmesartan medoxomil and hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetic Study of Pregabalin in Pediatric Patients With Partial Onset Seizures
Status: COMPLETED
Conditions: Epilepsies, Partial
Interventions: DRUG: Placebo|DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Genakumab for Injection in Patients With Gout Initiating Urico-lowering Therapy
Status: NOT_YET_RECRUITING
Conditions: Acute Gout|Gout Initiating Urico-lowering Therapy
Interventions: DRUG: Genakumab for injection|DRUG: Etoricorxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Analgesic Efficacy of the Pectoral Block After Mastectomy
Status: COMPLETED
Conditions: Analgesia
Interventions: PROCEDURE: PEC block + General anaesthesia|PROCEDURE: General anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of Traveler's Diarrhea Vaccine Patch
Status: COMPLETED
Conditions: Diarrhea
Interventions: BIOLOGICAL: Heat-Labile Enterotoxin of E. coli (LT)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Salvage HIFU for Local Recurrence in the Prostatic Bed After Prostatectomy and External Beam Radiation Therapy : Preliminary Results
Status: COMPLETED
Conditions: Prostatic Cancer
Interventions: OTHER: Retrospectively review of medical data in patients treated by Salvage HIFU for isolated macroscopic recurrence in the prostatic bed after radical prostatectomy and salvage or adjuvant EBRT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Oral Ladarixin in Recent Onset Type 1 Diabetes and a Low Residual β-cell Function
Status: ACTIVE_NOT_RECRUITING
Conditions: New-onset type1 Diabetes
Interventions: DRUG: Ladarixin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Colorectal Surgery Using Low-pressure Combined With Warm and Humidified Carbon Dioxide Insufflation
Status: RECRUITING
Conditions: Colorectal Surgery|Benign or Malignant Rectal or Colon Tumors
Interventions: PROCEDURE: Laparoscopic surgery under low pressure and warm and humidified CO2 Insufflation|PROCEDURE: Laparoscopic surgery under low pressure and conventional Insufflation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Terbogrel in Patients With Primary Pulmonary Hypertension
Status: COMPLETED
Conditions: Hypertension, Pulmonary
Interventions: DRUG: Terbogrel low dose|DRUG: Terbogrel high dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Localized Body Cooling Technology on Sleep and Metabolism in African, American With Overweight and Obesity
Status: RECRUITING
Conditions: Overweight or Obesity
Interventions: DEVICE: Moona Device|DEVICE: Inactive Moona Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of Brigatinib Plus Chemotherapy or Brigatinib Only in Advanced ALK-Positive Lung Cancer (MASTERPROTOCOL ALK)
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer|ALK Gene Mutation
Interventions: DRUG: Brigatinib 180 MG|DRUG: Carboplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomised Trial in Waldenstrom's Macroglobulinaemia
Status: COMPLETED
Conditions: Waldenstrom's Macroglobulinaemia
Interventions: DRUG: Bortezomib|DRUG: Cyclophosphamide|BIOLOGICAL: Rituximab|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Olanzapine on Opioid Craving and Misuse Among Patients Receiving Opioids for Cancer-related Pain: A Pilot Double-Blind, Randomized Control Trial
Status: RECRUITING
Conditions: Misuse, Opioid
Interventions: DRUG: Olanzapine|DRUG: Olanzapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Impact of Sucrose Ingestion Post-Exercise on Liver and Muscle Glycogen Repletion.
Status: COMPLETED
Conditions: Liver and Muscle Glycogen Replenishment Post-exercise
Interventions: DIETARY_SUPPLEMENT: Sucrose|DIETARY_SUPPLEMENT: Glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Glucosanol™ in Reducing Post-prandial Glucose Levels in Overweight Subjects
Status: COMPLETED
Conditions: Hyperglycemia, Postprandial
Interventions: DIETARY_SUPPLEMENT: Glucosanol 500mg|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Examining the Feasibility and Acceptability of Good Quality Intensive CBT for OCD and Good Quality Weekly CBT for OCD
Status: UNKNOWN
Conditions: Obsessive Compulsive Disorder (OCD)
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Anticancer Therapy of Paclitaxel and Everolimus for Relapsed or Refractory Small Cell Lung Cancer
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: taxol plus everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microdissection Testicular Sperm Extraction (MicroTESE) and IVF-ICSI Outcome in Non-Obstructive Azoospermia (NOA)
Status: COMPLETED
Conditions: Azoospermia|Infertility
Interventions: PROCEDURE: Microdissection Testicular Sperm Extraction|PROCEDURE: ICSI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effects of rTMS in Peripheral Neuropathic Pain
Status: COMPLETED
Conditions: Neuropathic Pain
Interventions: DEVICE: rTMS of prefrontal or motor cortex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Tisleizumab(BGB-A317) for dMMR/MSI-H Non-late Stage CRC Patients Before Surgery
Status: RECRUITING
Conditions: DMMR Colorectal Cancer|Anti PD-1|Immunotherapy
Interventions: DRUG: Tisleizumab(BGB-A317)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effects of Spironolactone With Chlortalidone on LV Mass in Patients With CKD
Status: UNKNOWN
Conditions: Renal Insufficiency, Chronic|Cardio-Renal Syndrome
Interventions: DRUG: Spironolactone|DRUG: Chlortalidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dedicated Lactation Support in Infants With Tongue - Tie; a Randomised Control Trial
Status: WITHDRAWN
Conditions: Ankyloglossia|Breast Feeding, Exclusive|Lactation Failure|Tongue-tie
Interventions: PROCEDURE: phrenectomy|OTHER: Increased lactation support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Randomized Sham-Controlled Study of H-Coil Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Late-Life Depression
Status: UNKNOWN
Conditions: Depression
Interventions: DEVICE: H- Coil DTMS|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Mycophenolate Mofetil Combined With Tacrolimus for Steroid Tapering in Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus|Lupus Nephritis
Interventions: DRUG: Mycophenolate Mofetil|DRUG: Tacrolimus|DRUG: Glucocorticoid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implications of Maternal 45,X Mosaicism as a Secondary Genomic Finding Following Cell-Free DNA Sequencing During Pregnancy: A Deep Phenotype Study
Status: NOT_YET_RECRUITING
Conditions: Cardiovascular Phenotype|Metabolic Phenotype|Hypertensive Disease|Psychological Phenotype|Audio
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intermittent Negative Pressure; Impact on Peripheral Artery Disease and Intermittent Claudication
Status: TERMINATED
Conditions: Peripheral Vascular Disease|Intermittent Claudication|Walking, Difficulty|Critical Limb Ischemia|Ischemia Limb
Interventions: DEVICE: Active FlowOx™|DEVICE: Sham FlowOx™ (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Heterogeneity in ASD: Biological Mechanisms, Trajectories, and Treatment Response
Status: ACTIVE_NOT_RECRUITING
Conditions: Children With Autism
Interventions: BEHAVIORAL: PARENT focused intervention|BEHAVIORAL: CHILD focused intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Genetic Education for Men Trial: Web-Based Education vs. Standard Care
Status: COMPLETED
Conditions: Prostate Carcinoma|Breast Neoplasm|Pancreatic Cancer|BRCA1 Mutation|BRCA2 Mutation
Interventions: BEHAVIORAL: Web-based Counseling|BEHAVIORAL: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of AN777 on Elderly Subjects During Bed Rest and Recovery
Status: COMPLETED
Conditions: Aged
Interventions: OTHER: Experimental Nutritional Powder Formula|OTHER: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of G-202 in Patients With Chemotherapy-Naïve Metastatic Castrate-Resistant Prostate Cancer
Status: WITHDRAWN
Conditions: Prostate Cancer.
Interventions: DRUG: G-202
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing Two Interventions to Improve Health Outcomes and Quality of Life Among Rural Older Adults Living With HIV
Status: RECRUITING
Conditions: HIV
Interventions: BEHAVIORAL: Supportive-Expressive Peer Social Support Group Intervention|BEHAVIORAL: Individual Strengths-Based Case Management Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Osteoporosis Choice Decision Aid for Use of Bisphosphonates in Postmenopausal Women
Status: COMPLETED
Conditions: Osteoporosis|Bone Loss, Age Related|Postmenopausal Bone Loss|Postmenopausal Osteoporosis
Interventions: BEHAVIORAL: Osteoporosis Choice Decision Aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Impact of Time on Sexual Function (FSFI® Score) After Hysterectomy
Status: NOT_YET_RECRUITING
Conditions: Time Between Hysterectomy and Resumption of Sexual Relations|Sexual Function
Interventions: OTHER: Recommended time after hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Analysis Of Intracranial Artery Lesions Using 2-D/3D Phase Contrast MR
Status: WITHDRAWN
Conditions: Intracranial Arterial Aneurysm
Interventions: RADIATION: Additional scan time on standard MR angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Examination of the Effect of Early Mobilization on Postoperative Recovery, Pain, Quality of Life and Complication Development in Elective Minimally Invasive Spine Surgery
Status: SUSPENDED
Conditions: Spine Fusion|Lumbar Disc Herniation|Cervical Disc Disease
Interventions: OTHER: intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial Comparing Oral Pilocarpine (Salagen) Versus Submandibular Salivary Gland Transfer Protocol, For the Prevention of Radiation (XRT) Induced Xerostomia in Head and Neck Cancer Patients
Status: COMPLETED
Conditions: Cancer|Head and Neck Cancer
Interventions: PROCEDURE: Submandibular gland Transfer|DRUG: Salagen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Different PEG-interferon and Ribavirin Schedules for Chronic Hepatitis C in the Real Clinical Practice.
Status: COMPLETED
Conditions: Hepatitis C Virus|Chronic Liver Disease|Viral Hepatitis|Therapeutic Uses|Antiviral Agents
Interventions: DRUG: peginterferon plus ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pivotal Study of HQP1351 in Patients With Chronic Myeloid Leukemia in Chronic Phase
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Myeloid Leukemia, Chronic Phase
Interventions: DRUG: HQP1351|DRUG: Hydroxyurea or Interferon-based therapy|DRUG: Homoharringtonine|DRUG: Imatinib, Dasatinib or Nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Function Following Thumb MP Fusion and IP Fusion
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DIAGNOSTIC_TEST: Jebsen Taylor Hand function test|DIAGNOSTIC_TEST: Pinch strength|DIAGNOSTIC_TEST: Grooved pegboard test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Inspiratory and Expiratory Pressure Training Methods in Patients With Chronic Obstructive Pulmonary Disease
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease(COPD)
Interventions: DEVICE: inspiratory pressure training group|DEVICE: mixed training group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotics and Prebiotics in Renal Function in Septic Acute Kidney Injury Patients
Status: UNKNOWN
Conditions: Acute Kidney Injury|Probiotics|Sepsis
Interventions: BIOLOGICAL: Probiotics|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Myocardial Iron After Iron Administration
Status: COMPLETED
Conditions: Heart Failure|Iron-deficiency
Interventions: DRUG: Ferric carboymaltose|DRUG: Placebo (Normal saline)|DIAGNOSTIC_TEST: Cardiac magnetic resonance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Clinical Trial of an Investigational COVID-19 Vaccine (BBV152) in Adult Volunteers
Status: UNKNOWN
Conditions: Covid19|SARS-CoV Infection
Interventions: BIOLOGICAL: BBV152|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Stress Ball Use on Anxiety Level During Endometrial Biopsy Procedure
Status: NOT_YET_RECRUITING
Conditions: Biopsy Wound|Endometrial Hyperplasia|Endometrial Neoplasms
Interventions: OTHER: stress ball|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Photobiomodulation and Manual Therapy Alone or Combined in TMD Patients
Status: COMPLETED
Conditions: Temporomandibular Disorder
Interventions: PROCEDURE: Photobiomodulation|PROCEDURE: Manual Therapy (MT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: WATER III: Aquablation vs. Transurethral Laser Enucleation of Large Prostates (80 - 180mL) in Benign Prostatic Hyperplasia
Status: RECRUITING
Conditions: BPH With Urinary Obstruction With Other Lower Urinary Tract Symptoms
Interventions: PROCEDURE: Aquablation therapy|PROCEDURE: Transurethral laser enucleation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Telatinib in Combination With Keytruda in Subjects With Advanced Stomach and Gastroesophageal Junction Cancers or Hepatocellular Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Cancer|Hepatocellular Carcinoma
Interventions: DRUG: Telatinib|DRUG: Keytruda
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial of Delayed Radiotherapy in Patients Low-grade Oligodendrogliomas Requiring a Treatment Other Than Surgery
Status: RECRUITING
Conditions: Oligodendroglioma|Low-grade Oligodendroglioma|1p19q Codeletion
Interventions: DRUG: PCV chemotherapy|DRUG: Radiotherapy and PCV chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The BASE Study: Bicarbonate Administration to Stabilize Estimated Glomerular Filtration Rate (eGFR)
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Lower Dose Sodium Bicarbonate|DRUG: Higher Dose Sodium Bicarbonate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Non Surgical Protocol for Treatment of Peri-implantitis
Status: UNKNOWN
Conditions: Peri-Implantitis
Interventions: PROCEDURE: mechanical debridement and chemical decontamination|PROCEDURE: Er:YAG laser|PROCEDURE: Air Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Examining the Cosmetic Results, Quality of Life and Patient Satisfaction Achieved With Skin Reducing Nipple Sparing Mastectomy and Implant Based Breast Reconstruction, and Comparing it to Classic Skin- Sparing Mastectomy and Implant- Based Breast Reconstructive Surgeries
Status: RECRUITING
Conditions: Breast Cancer|Mastectomy; Lymphedema|Quality of Life|Patient Satisfaction
Interventions: PROCEDURE: Skin Reducing Nipple Sparing Mastectomy and Implant Based Breast Reconstruction|PROCEDURE: Skin- Sparing Mastectomy and Implant- Based Breast Reconstructive Surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MAGE-A3/12 Metastatic Cancer Treatment With Anti-MAGE-A3/12 TCR-Gene Engineered Lymphocytes
Status: TERMINATED
Conditions: Metastatic Cancer|Metastatic Renal Cancer|Metastatic Melanoma
Interventions: BIOLOGICAL: PG13-MAGE-A3 TCR9W11 (anti-MAGE-A3/12 TCR) Transduced Autologous Peripheral Blood Lymphocytes|DRUG: Aldesleukin|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of ICG in Lymph Node Dissection During Radical Resection of Rectal Cancer With Preserved Autonomic Nerves Around LCA and IMA
Status: COMPLETED
Conditions: Indocyanine Green
Interventions: OTHER: non-ICG|DRUG: ICG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Mycobiome Supplementation on Gastrointestinal Symptoms in IBD Patients
Status: UNKNOWN
Conditions: Ulcerative Colitis|Crohn Disease|Inflammatory Bowel Diseases
Interventions: DIETARY_SUPPLEMENT: Mycodigest supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial)
Status: COMPLETED
Conditions: Small Abdominal Aortic Aneurysm
Interventions: DRUG: Beta-blocker-Atenolol 50mg, PO(peroral), Once daily|DRUG: Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ICE Study: Combination of Irinotecan Plus Cetuximab and Envafolimab as a Rechallenge Regimen in mCRC
Status: RECRUITING
Conditions: RAS Mutation|Metastatic Colorectal Cancer|MSS
Interventions: DRUG: irinotecan, cetuximab, envafolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 16-Week Study to Evaluate the Efficacy, Safety, and Tolerability of GLY-200 in Participants With Obesity
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: DRUG: GLY-200|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Factor Xa Inhibitor Versus Standard of Care Heparin in Hospitalized Patients With COVID-19 (XACT)
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Enoxaparin|DRUG: Rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: B-cell Immunity to Influenza (SLVP017)- Year 1, 2009
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluzone® 2009-2010 Formula|BIOLOGICAL: FluMist® 2009-2010 Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ultrasound-guided Inguinal Field Block (Genitofemoral, Iliohypogastric and Ilioinguinal Nerve Block) for Inguinal Hernia Surgery
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: OTHER: Triple inguinal nerve block.|OTHER: Unilateral subarachnoid anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anterior Open Bite Treatment With Bonded Spurs Associated With Build-ups Versus Conventional Bonded Spurs
Status: COMPLETED
Conditions: Malocclusion|Open Bite
Interventions: DEVICE: Bonded Spurs associated with posterior build-ups|DEVICE: Conventional bonded spurs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ex-vivo Expanded γδ T Lymphocytes in Patients With Refractory/Relapsed Acute Myeloid Leukaemia
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Ex-vivo Expanded γδ T Lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Modulation of Gene Expression and Metabolic Pathways in Glucose Metabolism
Status: COMPLETED
Conditions: Metabolic Syndrome|Obesity|Impaired Glucose Tolerance|Impaired Fasting Glucose
Interventions: DIETARY_SUPPLEMENT: Diet with increased intake of rye bread, berries and fish|DIETARY_SUPPLEMENT: Increased intake of whole grain and rye bread|DIETARY_SUPPLEMENT: Control diet with decreased intake of rye bread, berries and fish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalency Study of Ensartinib Capsules in Healthy Volunteers
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: ensartinib capsules (test product)|DRUG: ensartinib capsules (reference product)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prognostic Value of Circulating Tumoral Free DNA Versus Circulating Tumoral Cells in Patients With Colorectal Cancer Stage II-III
Status: UNKNOWN
Conditions: Colorectal Neoplasms
Interventions: BIOLOGICAL: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase II Trial of Lapatinib (TYKERB) + Pemetrexed (ALIMTA) in Advanced Non Small Cell Lung Cancer With an Initial Dose Finding Phase
Status: COMPLETED
Conditions: Lung Cancer, Non-Small Cell
Interventions: DRUG: Lapatinib|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EXperimental Paradigm to Investigate Expectation Change in Depression 4
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: BEHAVIORAL: Expectation confirmation|BEHAVIORAL: Expectation disconfirmation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Photodynamic Therapy in Treating Patients With Premalignant or Early Stage Head and Neck Tumors
Status: COMPLETED
Conditions: Head and Neck Cancer|Precancerous Condition
Interventions: DRUG: aminolevulinic acid hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of XmAb18087 ± Pembrolizumab in Advanced Merkel Cell Carcinoma or Extensive-stage Small Cell Lung Cancer
Status: TERMINATED
Conditions: Merkel Cell Carcinoma|Small Cell Lung Cancer
Interventions: BIOLOGICAL: XmAb18087|DRUG: XmAb18087 ± Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Navigation-Assisted TKA Using Mechanical vs. Restricted Kinematic Alignment
Status: RECRUITING
Conditions: Knee Arthroplasty, Total
Interventions: DEVICE: Optetrak Logic CR Knee System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of C105 on Cognitive Dysfunction in Persons With Multiple Sclerosis
Status: COMPLETED
Conditions: Cognition Disorders|Multiple Sclerosis
Interventions: DRUG: C105
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Oestradiol Suppression, Clinical Efficacy and Safety of Two Formulations of Triptorelin (Triptorelin Pamoate PR 3-month and Triptorelin Acetate PR 1-month) in Chinese Subjects With Endometriosis
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: Triptorelin Pamoate PR 3-month|DRUG: Triptorelin Acetate PR 1-month
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Fluzoparib Given in Combination With Apatinib and Paclitaxel in Gastric Cancer Patients
Status: UNKNOWN
Conditions: Recurrent and Metastatic Gastric Cancer
Interventions: DRUG: Fluzoparib|DRUG: Apatinib|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Curodont Repair or Placebo on the Remineralisation in Patients With Class 5 Carious Lesions
Status: COMPLETED
Conditions: Dental Caries
Interventions: DEVICE: Curodont Repair|OTHER: Placebo|DEVICE: Fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Lysozyme Goat Milk in Treating Patients With Blood Cancer Undergoing Donor Stem Cell Transplant
Status: WITHDRAWN
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Hematopoietic Cell Transplantation Recipient
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Cyclophosphamide|DRUG: Etoposide|DRUG: Goat Milk|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Palifermin|DRUG: Sirolimus|DRUG: Tacrolimus|RADIATION: Total-Body Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness and Safety of Campath in Combination With Tacrolimus Monotherapy to Prevent Kidney Graft Rejection
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: Alemtuzumab|DRUG: Tacrolimus|DRUG: Alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Polyester Implants for the Treatment of External Nasal Valve Collapse (NVC)
Status: TERMINATED
Conditions: Nasal Alar Collapse, Bilateral
Interventions: DEVICE: Polyester Implants
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rational EpigenetiC Immunotherapy for SEcond Line Therapy in Patients With NSCLC: PRECISE Trial
Status: COMPLETED
Conditions: Lung Cancer|Non-small Cell Lung Cancer
Interventions: DRUG: Nivolumab|DRUG: oral decitabine|DRUG: Tetrahydrouridine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study
Status: UNKNOWN
Conditions: Stage D Heart Failure
Interventions: DRUG: Sacubitril-Valsartan|DRUG: Usual care (standard-of-care) arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Forms of Oxcarbazepine for the Treatment of Bipolar Depression
Status: UNKNOWN
Conditions: Bipolar Depression|Treatment Effectiveness|Measure-based Guidance
Interventions: DRUG: Extended release oxcarbazepine vs Immediate release oxcarbazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Social, Emotional, Behavioral, and Academic Functioning
Status: ENROLLING_BY_INVITATION
Conditions: Depression, Anxiety|Disruptive Behavior Disorder|Trauma, Psychological
Interventions: BEHAVIORAL: Enhanced version of Interconnected Systems Framework|BEHAVIORAL: Positive Behavioral Interventions and Supports with Co-located School Mental Health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Etanercept Treatment in the Early Course of Polymyalgia Rheumatica
Status: COMPLETED
Conditions: Polymyalgia Rheumatica
Interventions: DRUG: Etanercept (Enbrel)|DRUG: Sodium chloride (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Customized Crosslinking: Safety and Efficacy in an Epithelium-off Accelerated-pulsated Protocol for Thin Keratoconus
Status: RECRUITING
Conditions: Keratoconus
Interventions: PROCEDURE: Corneal Cross Linking
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Screening for Colorectal Cancer in Older Patients (PLCO Screening Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Colon Carcinoma|Rectal Carcinoma
Interventions: OTHER: Screening Questionnaire Administration|PROCEDURE: Sigmoidoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: The Programmed Intermittent Epidural Bolus Adrenaline Study
Status: COMPLETED
Conditions: Labor Pain
Interventions: OTHER: Continuous epidural infusion|OTHER: Intermittent epidural bolus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Michigan Men's Diabetes Project 2
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Peer Led Diabetes Self-Management Support|BEHAVIORAL: Diabetes Self-Management Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Testosterone Topical Solution (LY900011) in Hypogonadal Men With Suboptimal Response to a Topical Testosterone Gel
Status: COMPLETED
Conditions: Hypogonadism
Interventions: DRUG: Topical Testosterone Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Effect of 24 Weeks of Treatment With Vildagliptin in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Vildagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Automatic Chlorination and Child Health in Urban Bangladesh
Status: COMPLETED
Conditions: Diarrhea|Communicable Diseases
Interventions: DEVICE: Water chlorination by the Flogenic|DEVICE: Active control, vitamin C dosing into water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: EndoACAB vs PCI for LAD Revascularization
Status: UNKNOWN
Conditions: Coronary Artery Disease|Cardiovascular Diseases|Myocardial Ischemia
Interventions: PROCEDURE: Endoscopic coronary arterial bypass|PROCEDURE: Percutaneous Coronary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study for an Oral Contraceptive Containing Folate
Status: COMPLETED
Conditions: Neural Tube Defects|Contraception|Oral Contraceptives (OC)
Interventions: DRUG: Drospirenone/Ethinylestradiol/Methyltetrahydrofolate|DRUG: Drospirenone/Ethinylestradiol (Yaz)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Traveling-wave Transcranial Electric Stimulation
Status: RECRUITING
Conditions: Working Memory
Interventions: DEVICE: Transcranial alternating current stimulation (tACS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective, Multicenter, Randomized, Open-label Study of 12 Week Duration to Evaluate the Effect of VILDagliptin Added to Insulin on Glycaemic Control in haemoDIALyzed Patients With Type 2 Diabetes: Probe Analysis of CGM
Status: COMPLETED
Conditions: Haemodialyzed, Type 2 Diabetes
Interventions: DRUG: Vildagliptin (Galvus)|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Phenotyping in Patients With Neuropathic Pain After Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries|Pain, Neuropathic|Nociceptive Pain|Neuropathy
Interventions: DIAGNOSTIC_TEST: Neurophysiology|DIAGNOSTIC_TEST: Cardiovascular test|DIAGNOSTIC_TEST: Experimental pain paradigms|DIAGNOSTIC_TEST: Quantitative sensory testing|DIAGNOSTIC_TEST: Clinical pain phenotype
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study: Geniculate Artery Embolization in Knee Osteoarthrosis.
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: Geniculate Artery Embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Web-Based Module on Nursing Students' Knowledge, Practice and Attitude Regarding Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: PCOS
Interventions: OTHER: Web-Based Learning Module (WBL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Prolene Thread Seton Vs Silk Thread Seton for the Treatment of Perianal Fistula
Status: COMPLETED
Conditions: Perianal Fistula
Interventions: PROCEDURE: prolene seton treatment|PROCEDURE: silk seton treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intermittent Oro-esophageal Tube Feeding on Severe Traumatic Brain Injury Patient
Status: WITHDRAWN
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: Rehabilitation therapy|DEVICE: Intermittent Oro-esophageal Tube Feeding|DEVICE: Nasogastric tube feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Early Left Bundle Branch Pacing for Cardiac Resynchronization Therapy
Status: RECRUITING
Conditions: Heart Failure|Left Bundle Branch Pacing
Interventions: DEVICE: LBBP+GDMT|DRUG: GDMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flutamide, Suramin, and Hydrocortisone in Treating Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: flutamide|DRUG: goserelin acetate|DRUG: leuprolide acetate|DRUG: suramin|DRUG: therapeutic hydrocortisone|PROCEDURE: orchiectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effect of the Use of Washing Solutions at Different Temperatures Used in Intra-arterial Cannulation
Status: NOT_YET_RECRUITING
Conditions: Intrarterial Catheterization
Interventions: OTHER: intra-arterial flushing|OTHER: intra-arterial flushing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Double-blind, Randomized Conversion to Monotherapy Study to Evaluate the Efficacy and Safety of Brivaracetam in Subjects (≥ 16 to 75 Years Old) With Partial Onset Seizures
Status: TERMINATED
Conditions: Epilepsy
Interventions: DRUG: Brivaracetam|DRUG: Brivaracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Value of 18F-FAZA PET Imaging in Patients With Breast Cancer
Status: TERMINATED
Conditions: Breast Neoplasm
Interventions: DRUG: 18F-FAZA PET scan|DRUG: FluGlucoScan Injection (18F-FDB) PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pain and Neck Dysfunction Following Dry Needling With and Without Intramuscular Electrical Stimulus.
Status: COMPLETED
Conditions: Neck Pain|Shoulder Pain|Myofascial Pain
Interventions: PROCEDURE: Dry Needling (DN)|PROCEDURE: Dry needling with Intramuscular electrical stimulation (DNES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Pneumatic Versus Ultra-sonic Percutaneous Nephrolithotomy in Large Kidney Stones
Status: COMPLETED
Conditions: Kidney Stone
Interventions: PROCEDURE: Pneumatic percutaneous nephrolithotomy|PROCEDURE: Ultra-sonic percutaneous nephrolithotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Clobetasol Propionate 0.05% E Foam in Alopecia
Status: UNKNOWN
Conditions: Alopecia
Interventions: DRUG: Clobetasol Propionate 0.05% Emollient Foam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dydrogesterone-Primed Ovarian Stimulation Protocol Versus Gonadotropin Releasing Hormone Antagonist Protocol in ICSI
Status: RECRUITING
Conditions: Ovary Cyst|Fertility Issues
Interventions: OTHER: progestin primed ovarian stimulation protocol|DRUG: dydrogesterone (Duphaston, Abbott)|DRUG: Cetrotide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Rosiglitazone on the Vascular Biology of Human Fat Tissue
Status: COMPLETED
Conditions: Metabolic Syndrome|Insulin Resistance
Interventions: DRUG: Rosiglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Autologous Cartilage Implantation vs Arthroscopic Debridement
Status: UNKNOWN
Conditions: Knee Injury|Cartilage Injury
Interventions: PROCEDURE: Autologous Chondrocyte Implantation|PROCEDURE: Arthroscopic Debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of IntraVascular UltraSound Guidance on Outcomes of Xience Prime Stents in Long Lesions (IVUS-XPL Study)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: PCI with IVUS guidance|PROCEDURE: PCI without IVUS guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stress-Echography in Hereditary Haemorrhagic Telangiectasia Patient With Hepatic Involvement
Status: RECRUITING
Conditions: Hereditary Hemorrhagic Telangiectasia|Rendu Osler Disease
Interventions: OTHER: Stress echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cabozantinib and Pembrolizumab for the First-Line Treatment of Advanced Liver Cancer
Status: TERMINATED
Conditions: Advanced Hepatocellular Carcinoma|BCLC Stage B Hepatocellular Carcinoma|BCLC Stage C Hepatocellular Carcinoma
Interventions: DRUG: Cabozantinib S-malate|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Venetoclax in Combination With Azacytidine in AML Patients Selected Using Ex Vivo Drug Sensitivity Screening
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk of Post-polypectomy Bleeding With Prophylactic Hemoclipping
Status: COMPLETED
Conditions: Post-polypectomy Bleeding|Polypectomy|Elective Colonoscopy
Interventions: DEVICE: Hemoclip Placement|DEVICE: NO hemoclip placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neuromuscular Electrical Stimulation and Strength Training in Patients With Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: OTHER: Neuromuscular Electrical Stimulation|OTHER: ECR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anastrozole 1 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Anastrozole (Teva Pharmaceuticals USA)|DRUG: Anastrozole (Arimidex®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Effect of BIBT 986 Followed by BIBT 986 Given as IV Infusion on Tissue Factor Triggered Coagulation in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Low dose of BIBT 986 CL, per i.v. infusion|DRUG: Medium dose of BIBT 986 CL, per i.v. infusion|DRUG: High dose of BIBT 986 CL, per i.v. infusion|DRUG: Placebo|DRUG: Lipopolysaccharide (LPS), single i.v. bolus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT