pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of Varespladib Infusion in Subjects With Sickle Cell Disease.
Status: TERMINATED
Conditions: Sickle Cell Disease|Vaso-occlusive Crisis
Interventions: DRUG: Varespladib|OTHER: Placebo (Normal Saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study in Subjects With Mild-to-Moderate Alzheimer's Dementia
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer Disease
Interventions: BIOLOGICAL: ALZN002 (autologous DCs pulsed with E22W mutant peptide).|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Cinacalcet to Improve Achievement of National Kidney Foundation Kidney Disease Outcomes Quality Initiative (K/DOQI) Targets in Patients With End Stage Renal Disease (ESRD)
Status: COMPLETED
Conditions: Anemia|Secondary Hyperparathyroidism
Interventions: DRUG: Cinacalcet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Loco-Regional Liposomal Bupivacaine Injection
Status: RECRUITING
Conditions: Peripheral Arterial Disease
Interventions: DRUG: Bupivacaine liposome|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Inspiratory Muscle Training on Postural Stability, Posture Perception and Trunk Rotation in Children With Adolescent Idiopathic Scoliosis.
Status: COMPLETED
Conditions: Adolescent Scoliosis
Interventions: OTHER: Conventional Scoliosis Exercise Program|OTHER: Inspiratory Muscle Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Continuous Egg Supplement on Personalized Nutri-omics in Primary School Children (SI-EGG STUDY)
Status: COMPLETED
Conditions: Malnutrition, Child
Interventions: DIETARY_SUPPLEMENT: whole eggs|DIETARY_SUPPLEMENT: yolk-free egg substitutes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The ENERGY Study: Evaluation of Safety and Tolerability of INZ-701 in Infants With ENPP1 Deficiency or ABCC6 Deficiency
Status: RECRUITING
Conditions: Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency|Autosomal Recessive Hypophosphatemic Rickets|Generalized Arterial Calcification of Infancy|ATP-Binding Cassette Subfamily C Member 6 Deficiency|Pseudoxanthoma Elasticum
Interventions: DRUG: INZ-701
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Normative Metrics of High-Resolution Anorectal Manometry With the Use of Water-perfused System in a Healthy Russian Cohort
Status: UNKNOWN
Conditions: Healthy Subjects
Interventions: DIAGNOSTIC_TEST: High resolution anorectal manometry, water perfused catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Telehealth-Enabled Versus In-Person Parent-Mediated Behavioral Treatment for Challenging Behaviors in Children With ASD
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Behavior therapy|OTHER: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Fixed Combination Therapy of Vildagliptin and Metformin Compared to the Individual Monotherapy Components in Drug Naive Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Vildagliptin|DRUG: Metformin|DRUG: Vildagliptin + Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Bomedemstat (MK-3543) in Participants With Polycythemia Vera (MK-3543-004)
Status: ACTIVE_NOT_RECRUITING
Conditions: Polycythemia Vera
Interventions: DRUG: Bomedemstat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Investigation of Effect on Blood Lipid Parameters With Walnut Addition of Diet
Status: COMPLETED
Conditions: Cardiovascular Risk Factor
Interventions: DIETARY_SUPPLEMENT: The Investigation of effect on Blood Lipid parameters with walnut addition of Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: High Versus Free Humidity Incubators; A Randomized Clinical Trial
Status: COMPLETED
Conditions: Ongoing Pregnancy Rate
Interventions: OTHER: The Embryos will be cultured on a humidity free incubator|OTHER: The Embryos will be cultured on a >95% humidity incubator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Closure Of Patent Ductus Arteriosus With the AMPLATZER Duct Occluder the AMPLATZER® Duct Occluder
Status: COMPLETED
Conditions: Patent Ductus Arteriosus (PDA)
Interventions: DEVICE: Device closure with AMPLATZER Duct Occluder|OTHER: Objective Performance Criteria
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Unselected Hematopoietic Stem Cell Transplantation for Refractory Crohn's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn's Disease|Inflammatory Bowel Diseases|Gastroenteritis
Interventions: PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetic Testing in Guiding Treatment for Patients With Brain Metastases
Status: RECRUITING
Conditions: CDK Gene Mutation|Metastatic Malignant Neoplasm in the Brain|Metastatic Malignant Solid Neoplasm|NTRK Family Gene Mutation|PI3K Gene Mutation|ROS1 Gene Mutation|KRAS G12C Mutation
Interventions: DRUG: Abemaciclib|DRUG: PI3K Inhibitor paxalisib|DRUG: Entrectinib|DRUG: Adagrasib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correlation and Comparison of the HepQuant® Disease Severity Index (DSI) With Hepatic Venous Pressure Gradient (HVPG)
Status: COMPLETED
Conditions: Liver Disease
Interventions: DRUG: HepQuant-SHUNT (Drug and Device) #65,123 (4D-cholate) and IND #65,121 (13C-cholate)|DEVICE: Hepatic Venous Pressure Gradient (HVPG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Decontaminant Agent in the Treatment of Chronic Periodontitis
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: PROCEDURE: Hybenx treatment (device)|PROCEDURE: Scaling and Root Planing (SRP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: NovoTTF-200A Device in Treating Patients With Newly Diagnosed High Risk Oligodendroglioma
Status: WITHDRAWN
Conditions: Anaplastic Oligodendroglioma|Oligoastrocytoma|Oligodendroglioma
Interventions: DEVICE: Wear novoTTF-200A|PROCEDURE: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laryngeal Allograft Transplantation
Status: ENROLLING_BY_INVITATION
Conditions: Larynx Stenosis|Larynx Disease|Laryngectomy|Larynx|Larynx Fracture
Interventions: PROCEDURE: Larynx Allograft Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Echocardiography Guided Cardiac Resynchronization Therapy (EchoCRT)
Status: TERMINATED
Conditions: Heart Failure|Ventricular Dyssynchrony
Interventions: DEVICE: Implantable Cardioverter Defibrillator with Cardiac Resynchronization Therapy (BIOTRONIK Lumax HF-T CRT-D)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Drinks Containing Fruit Polyphenol Extracts and Fibre on Postprandial Glycaemia. (Glu-MIX)
Status: COMPLETED
Conditions: Postprandial Period
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Polyphenol and fibre|DIETARY_SUPPLEMENT: Fibre
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Ferumoxytol for Magnetic Resonance Imaging of Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: OTHER: Ferumoxytol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of CryoCor™ Cryoablation for PAF
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Cardiac CryoCor Cryoablation System|DRUG: Medical management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Spanish Language Homes
Status: COMPLETED
Conditions: Dementia|Mild Cognitive Impairment|Alzheimer Disease
Interventions: DEVICE: In-Home Technology System|DEVICE: Limited In-Home Technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Decreasing Severity of Acne Vulgaris After the Use of a Combination of Anti-Acne Cream
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Anti-Acne Preparations for Topical Use
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BOTOX® Versus Zanaflex® for the Treatment of Post-Stroke or Traumatic Brain Injury Upper Limb Spasticity
Status: COMPLETED
Conditions: Upper Limb Spasticity
Interventions: DRUG: BOTOX®|DRUG: Zanaflex®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of a Diabetes Specialist Nurse-led Smoking Cessation Intervention
Status: RECRUITING
Conditions: Diabetes Mellitus|Tobacco Use Cessation
Interventions: OTHER: Diabetes specialist nurse-led multi-component smoking cessation intervention|BEHAVIORAL: Health Promotion and Disease Prevention Directorate's one-to-one smoking cessation service (standard care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Randomized Trial of a Comprehensive Transitional Care Program for Colorectal Cancer Patients
Status: WITHDRAWN
Conditions: Colorectal Cancer|Comprehensive Transitional Care Program
Interventions: OTHER: Patient education: One-on-one visit|OTHER: Discharge planning: Assessment of barriers to discharge|OTHER: Medication reconciliation: Patient medication review|OTHER: Appointment before discharge: Additional measure to ensure awareness of next clinic visit|OTHER: Transition coach|OTHER: Patient-centered discharge instructions: Enhanced|OTHER: Provider continuity: Specific surgeons responsible for coordinating care with medical/radiation oncology|OTHER: Timely follow-up: Barriers to clinic follow-up visits will be discussed|OTHER: Timely PCP communication|OTHER: Follow-up telephone call|OTHER: Patient hotline: 24 hour follow-up following call to Ask My Nurse number
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose:
Clinical trial: Efficacy of Anterior Wall PVI With QDOT Catheter - Intraprocedural Comparison Between vHPSD and HPSD Ablation.
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: QMODE +|DEVICE: QMODE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correlation Between Tissue and Plasmatic EGFR in CBNPC With EGFR Mutation or Predictive Factor of EGFR Mutation
Status: TERMINATED
Conditions: Nsclc
Interventions: PROCEDURE: Clinical exam|PROCEDURE: Liquid biopsy|PROCEDURE: Diagnostic exam|DRUG: 1st line treatment|PROCEDURE: tumor evaluation|BIOLOGICAL: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Irinotecan and Bortezomib in Children With Recurrent/Refractory Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: DRUG: Irinotecan and Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fulvestrant, Palbociclib and Erdafitinib in ER+/HER2-/FGFR-amplified Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Erdafitinib|DRUG: Palbociclib|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SM-88 Maintenance Therapy for Advanced Ewing's Sarcoma and as Salvage Therapy for Sarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcoma, Ewing|Sarcoma
Interventions: DRUG: Combination metyrosine-derivative, low-dose methoxsalen, phenytoin and sirolimus (MPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Kinesiotaping on Activation of Abdominal Muscles in Female Patients With Stress Urinary Incontinence
Status: NOT_YET_RECRUITING
Conditions: Stress Urinary Incontinence
Interventions: OTHER: Kinesio taping|OTHER: Pelvic floor exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ropivacaine Use in Interscalene Block; What is the Minimal Effective Analgesic Concentration (MEAC 90)
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment of Acupuncture for the Treatment of Chronic Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: Verum acupuncture|DEVICE: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Noninferiority Study of Alglucosidase Alfa Manufactured at the 160 L and 4000 L Scales in Treatment Naïve Patients With Infantile-Onset Pompe Disease
Status: TERMINATED
Conditions: Pompe Disease (Infantile-Onset)|Glycogen Storage Disease Type II (GSD II)|Glycogenosis 2|Acid Maltase Deficiency
Interventions: BIOLOGICAL: alglucosidase alfa|BIOLOGICAL: alglucosidase alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Validation of Nutritional Supplements Developed for Pancreaticobiliary Cancer Patients
Status: COMPLETED
Conditions: Pancreaticobiliary Cancer
Interventions: DIETARY_SUPPLEMENT: Routine care + Nutritional product|OTHER: Routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lenalidomide and Dexamethasone Versus Melphalan Prednisone and Lenalidomide Versus Cyclophosphamide, Prednisone and Lenalidomide in Elderly Multiple Myeloma Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Melphalan, Prednisone, Lenalidomide|DRUG: Cyclophosphamide, Prednisone, Lenalidomide|DRUG: Lenalidomide, dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS)
Status: RECRUITING
Conditions: Acute Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: RADIATION: Total-Body Irradiation|DRUG: Thiotepa|DRUG: Fludarabine|DRUG: Tacrolimus|BIOLOGICAL: Allogeneic CD34+-enriched and CD45RA-depleted PBSCs|DRUG: Methotrexate|DRUG: Cyclophosphamide|BIOLOGICAL: Peripheral Blood Stem Cell|DRUG: Cyclosporine|DRUG: Sirolimus|DRUG: Busulfan|PROCEDURE: Bone Marrow Aspiration and Biopsy|PROCEDURE: Echocardiography|PROCEDURE: Multigated Acquisition Scan|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Taping on Anastomotic Regions in Patients With Breast Cancer-Related Lymphoedema
Status: COMPLETED
Conditions: Breast Cancer Lymphedema|Compression Bandages|Manual Lymphatic Drainage
Interventions: OTHER: Decongestive Physiotherapy|OTHER: Decongestive Physiotherapy plus taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of the Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 Origins
Status: RECRUITING
Conditions: Hyperpigmentation
Interventions: OTHER: serum formula 2039125 03
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of Platelet Rich Plasma Injections in Patients With Adhesive Capsulitis of the Shoulder
Status: COMPLETED
Conditions: Adhesive Capsulitis of Shoulder|Adhesive Capsulitis|Frozen Shoulder
Interventions: BIOLOGICAL: PRP|OTHER: Saline injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-142886)
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Breast Neoplasms|Colon Cancer|Colonic Cancer|Colon Neoplasms|Lung Cancer|Melanoma|Kidney Cancer
Interventions: DRUG: AZD6244|DRUG: Dacarbazine|DRUG: Erlotinib|DRUG: Docetaxel|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Prospective Study of Diarrhea Tolerance of Pyrotinib Combined With Trastumab and Taxane in the First-line Treatment of HER2-positive Advanced Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab+pyrotinib+taxene
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dry Run of the ScreenUrSelf Trial
Status: COMPLETED
Conditions: Cervical Cancer|Cervical Intraepithelial Neoplasia|Human Papilloma Virus|HPV-Related Cervical Carcinoma
Interventions: DEVICE: Colli-Pee Small Volumes|DEVICE: Evalyn Brush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect Of PF-03654764 +/- Allegra On Symptoms Of Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: PF-03654764|DRUG: Allegra|DRUG: PF-03654764|DRUG: Allegra-D|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of a Tenofovir-containing Drug Regimen for the Prevention of Mother-to-child Transmission of HIV and HBV
Status: COMPLETED
Conditions: HIV|Hepatitis B
Interventions: DRUG: Tenofovir/lamivudine/lopinavir-ritonavir|DRUG: Zidovudine/lamivudine/lopinavir-ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Electro-Hyperthermia in Preoperative Radiotherapy for Locally Advanced Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Cancer|Hyperthermia
Interventions: DEVICE: Electro-hyperthermia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clear Me: Interception Trial to Detect and Clear Molecular Residual Disease in Patients With High-risk Melanoma
Status: RECRUITING
Conditions: Cutaneous Melanoma|Melanoma Stage IV|Mucosal Melanoma
Interventions: DRUG: Opdualag|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Addition of Magnesium Sulfate in Spinal Anesthesia on Sensory-Motor Blocks and Postoperative Pain in Lumbar Disk Herniation Surgery
Status: COMPLETED
Conditions: Lumbar Spine Disc Herniation
Interventions: DRUG: Magnesium Sulfate|PROCEDURE: Spinal Anesthesia|DRUG: Bupivacaine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Varying Doses of Amino Acids on Exercise, Muscular and Mental Performance
Status: COMPLETED
Conditions: Psychological Phenomena: Central Fatigue
Interventions: DIETARY_SUPPLEMENT: AminoVital Amino Acid formulation|DIETARY_SUPPLEMENT: Amino Vital Amino Acid formulation|DIETARY_SUPPLEMENT: Amino Vital Amino Acid formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AlloCare - Support and Management of Late Effects After Allogeneic Hematopoietic Stem Cell Transplantation
Status: NOT_YET_RECRUITING
Conditions: Hematological Diseases
Interventions: BEHAVIORAL: AlloCare
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Ketalar or Dexmedetomidine on Increased Sensitivity to Pain Following Treatment With Remifentanil
Status: RECRUITING
Conditions: Cholecystectomy
Interventions: DRUG: Ketalar|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Safety and Tolerability of AZD0530 in Combination With Carboplatin and Paclitaxel
Status: WITHDRAWN
Conditions: Cancer|Non Small Cell Lung Cancer|Epithelial Ovarian Cancer
Interventions: DRUG: AZD0530|DRUG: Carboplatin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bellomic PCA in Laparoscopic Gynecologic Surgery
Status: COMPLETED
Conditions: Laparoscopic Gynecological Surgery
Interventions: DRUG: Fentanyl selector|DRUG: Fentanyl continuous|DRUG: Ketorolac continuous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Evaluation of the Effect of Riboflavin Supplementation on Blood Pressure and Possible Effect Modification by the MTHFR C677T Genotype
Status: TERMINATED
Conditions: High Blood Pressure|MTHFR C677T Genotype
Interventions: DIETARY_SUPPLEMENT: Riboflavin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A fMRI Study of the Treatment of Danish Veterans With PTSD With Prolonged Exposure Therapy
Status: UNKNOWN
Conditions: Stress Disorders, Post-Traumatic
Interventions: BEHAVIORAL: Prolonged Exposure Therapy|BEHAVIORAL: Observation|DEVICE: fMRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Culturally Adapted Psychoeducation (CaPE) for Bipolar Disorders in Nigeria
Status: NOT_YET_RECRUITING
Conditions: Bipolar Disorder
Interventions: BEHAVIORAL: Culturally adapted Psychoeducation (CaPE)|DRUG: Treatment as Usual (TaU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Single-Arm Phase 2 Study With Optimized Standard Protocol for Severe Aplastic Anemia
Status: UNKNOWN
Conditions: Aplastic Anemia
Interventions: DRUG: rabbit ATG, Cyclosporine, Levamisole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Efficacy Evaluation of Integrated Chronic Care and Health Promotion Model for Patients With Coronary Artery Disease in Taiwan
Status: UNKNOWN
Conditions: Acute Myocardial Infarction|Stable Angina
Interventions: BEHAVIORAL: Integrated health care team|OTHER: Traditional group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study Evaluating Chemotherapy in Combination With Inotuzumab Ozogamicin In Subjects With Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma, B-Cell
Interventions: DRUG: inotuzumab ozogamicin+rituximab +cyclophosphamide+vincristine+prednisone|DRUG: inotuzumab ozogamicin+rituximab+gemcitabine+cisplatinum+dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Community-based Study Comparing Extended-release Methylphenidate and Atomoxetine in Children With Attention-deficit Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Methylphenidate extended-release; Atomoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smoking Relapse Prevention Via Just-in-Time-Adaptive Interventions
Status: UNKNOWN
Conditions: Smoking Cessation
Interventions: OTHER: NRT + QuitBuddy|OTHER: NRT + QuitBuddy-Recall|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of SennaS for Prevention of Post-operative Constipation After Urogynecologic Surgery
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: Senna+ docusate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Resection vs. Best Supportive Care for Hepatocellular Carcinoma (HCC) With Portal Venous Thrombus
Status: TERMINATED
Conditions: Hepatocellular Carcinoma With Portal Vein Tumor Thrombus
Interventions: PROCEDURE: Liver resection plus Thrombectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone Therapy for Low Back Pain
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: DRUG: IV Dexamethasone Therapy|OTHER: IV Normal Saline (NaCl 0.9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of Polyethylene Glycol Loxenatide in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: PEX168
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Initial Effectiveness of Transcranial MR Guided Focused Ultrasound for the Treatment of Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: DEVICE: ExAblate Neuro Thalamotomy Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Vedolizumab Combined With Upadacitinib in Patients With Ulcerative Colitis
Status: RECRUITING
Conditions: Crohn Disease
Interventions: DRUG: Upadacitinib|DRUG: Vedolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicentre ObseRvational Study in Posterior mecHanical thrombEctomy: conscioUs Sedation vs General aneSthesia
Status: COMPLETED
Conditions: Mechanical Thrombectomy|General Anesthesia|Conscious Sedation|Posterior Circulation
Interventions: PROCEDURE: Type of anesthesia choice
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 1, Open-label Study to Investigate the Pharmacokinetics of Tralokinumab (CAT-354) in Adolescents With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: Tralokinumab 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SB939 in Treating Patients With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: HDAC inhibitor SB939|OTHER: immunoenzyme technique|OTHER: immunohistochemistry staining method|OTHER: immunologic technique|OTHER: laboratory biomarker analysis|OTHER: liquid chromatography|OTHER: mass spectrometry|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Study Different Levels of MK0493 for Safety, Efficacy, and Tolerability in Obese Patients (0493-017)(COMPLETED)
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: MK0493
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Equivalence of the Test and Reference Metered Dose Inhalers (MDIs) Containing Albuterol Sulfate in Adult Patients With Stable Mild Asthma
Status: RECRUITING
Conditions: Mild Asthma
Interventions: DRUG: Albuterol Sulfate inhalation aerosol 108 mcg per actuation|DRUG: Proair HFA (Albuterol Sulfate) or FDA authorized generic: Albuterol Sulfate HFA (Teva Pharmaceutical USA, Inc.) Inhalation Aerosol 108 mcg per actuation|OTHER: Proair HFA or FDA authorized generic: Albuterol Sulfate HFA Inhalation Placebo|OTHER: Albuterol Sulfate inhalation Placebo|OTHER: Methacholine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Electrical Stimulation and Chemotherapy Induced Peripheral Neuropathy
Status: UNKNOWN
Conditions: Chemotherapy Induced Peripheral Neuropathy (CIPN)
Interventions: DEVICE: longwave diathermy on high power and interferential therapy|DEVICE: longwave diathermy on low power
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Open, Non-controlled Clinical Investigation to Evaluate a New Negative Pressure Wound Therapy (NPWT) System to be Used in the Treatment of Acute Non-infected Wounds and Post Surgical Infected Wounds
Status: COMPLETED
Conditions: Acute Non Infected Wounds|Non Infected Post Surgical Wounds
Interventions: DEVICE: New NPWT system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concurrent Oxytocin With Membrane Sweeping Versus Dinoprostone Pessary in Labor Induction of Multiparous Women at Term
Status: COMPLETED
Conditions: Failed Induction of Labor
Interventions: DRUG: Oxytocin|DRUG: Dinoprostone|PROCEDURE: Membrane sweeping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Sargramostim in Treating Patients With Mild Cognitive Impairment Due to Alzheimer's Disease
Status: WITHDRAWN
Conditions: Dementia Alzheimer's Type
Interventions: DRUG: Sargramostim GZ402664|DRUG: Placebo|DRUG: Florbetapir F18
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Classification of Comprehensive Treatment Effect of Hepatocellular Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma|Immunotherapy
Interventions: PROCEDURE: Immunotherapy combined with targeted therapy|OTHER: Standard treatment plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Structural Stability of Carotid Plaque and Symptomatology
Status: COMPLETED
Conditions: Carotid Stenosis|Stroke|Carotid Artery Plaque|Transient Ischemic Attack|Cerebrovascular Accident|Carotid Artery Stenosis
Interventions: PROCEDURE: Carotid Endarterectomy or Stenting
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Identification of Neuromotor Signs in Preschool Children Suspected of Developmental Coordination Disorder
Status: COMPLETED
Conditions: Motor Skills Disorders|Child Development|Child, Preschool
Interventions: DIAGNOSTIC_TEST: Little Developmental Coordination Disorder Questionnaire (LDCDQ)|DIAGNOSTIC_TEST: Bruininks- Oseretsky Test of Motor Proficiency 2nd Edition (BOT-2)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and TDM of Continuous Infusion Vancomycin Through Continuous Renal Replacement Therapy Solution
Status: UNKNOWN
Conditions: Pediatric Continuous Renal Replacement Therapy|Dialysis|Renal Failure
Interventions: DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety/Efficacy Of Daratumumab With Belatacept In Highly HLA-Sensitized Patients Awaiting Kidney Transplantation
Status: RECRUITING
Conditions: Sensitisation|Highly Sensitised Dialysis Patients
Interventions: COMBINATION_PRODUCT: Each patient will undergo in the first step of the study belatacept treatment and in the second apheresis and daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Safety Study of Enteric-Coated Spheroid Suspension in Infants Aged Less Than 12 Months With Presumed Gastroesophageal Reflux Disease (GERD)
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: pantoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Survey About Diet in Chronic Inflammatory Rheumatic Diseases
Status: UNKNOWN
Conditions: Rheumatic Disease|Rheumatic Disorder|Inflammatory Rheumatism|Rheumatoid Arthritis|Psoriatic Arthritis|Spondyloarthritis|Spondylitis, Ankylosing|Diet Habit|Feeding Behavior
Interventions: OTHER: Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics and Safety of Roledumab in RhD-negative Pregnant Women Carrying an RhD-positive Foetus
Status: COMPLETED
Conditions: Rh Disease
Interventions: DRUG: ROLEDUMAB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: LUCHAR - Latinos Using Counseling for Help With Asthma and Anxiety Reduction
Status: COMPLETED
Conditions: Asthma|Panic Disorder
Interventions: BEHAVIORAL: Music Relaxation Therapy (MRT)|BEHAVIORAL: CBT and HRVB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Antibiotics on Gut Microbiome and Plasma Metabolome
Status: COMPLETED
Conditions: Microbial Colonization
Interventions: DRUG: Amoxicillin|DRUG: Azithromycin|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement
Status: RECRUITING
Conditions: Tooth Mobility|Injectable Platelet-rich Fibrin
Interventions: DEVICE: injectable form of PRF|BEHAVIORAL: Placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose Study To Assess Safety, Tolerability And Pharmacokinetics Of PF-05212377 (SAM-760)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-05212377 (SAM-760)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Total Knee Arthroplasty: Fast Track Protocol is the Future?
Status: RECRUITING
Conditions: Osteoarthritis, Knee|Arthropathy of Knee
Interventions: PROCEDURE: fast track care protocol|PROCEDURE: standard care protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Surgical Site Infection in Caesarean Section Using Alexis O Compared to Metal Retractors
Status: COMPLETED
Conditions: Surgical Site Infection
Interventions: DEVICE: Alexis O Retractor|DEVICE: Metal Retractor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of ARB-001467 in Subjects With Chronic HBV Infection Receiving Nucleos(t)Ide Analogue Therapy
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: ARB-001467|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Investigating Stimulation Parameter and Electrode Mode Changes on Speech Perception in Experienced Adult Cochlear Implant Recipients
Status: RECRUITING
Conditions: Hearing Loss, Sensorineural
Interventions: DEVICE: Program using default MAP|DEVICE: Program using low-power 1 (LP1) MAP|DEVICE: Program using low-power 2 (LP2) MAP|DEVICE: Program using low-power 3 (LP3) MAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Determine How Effective Duloxetine is in Treating Women 65 Years and Older With Symptoms of Stress Urinary Incontinence, or With a Combination of Stress Urinary Incontinence and Urge Urinary Incontinence Symptoms
Status: COMPLETED
Conditions: Urinary Incontinence, Stress
Interventions: DRUG: Duloxetine hydrochloride|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Neoadjuvant PEMbrolizumab Before Radical PROstatectomy in High-risk Prostate Cancer Patients
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Menactra® in Healthy Subjects at 9 Months and Concomitantly With Pentacel® at 15 to 18 Months of Age
Status: COMPLETED
Conditions: Meningitis|Meningococcal Infection|Diphtheria|Tetanus|Pertussis|Haemophilus Influenzae Serotype b (Hib)
Interventions: BIOLOGICAL: Meningococcal polysaccharide diphtheria toxoid conjugate|BIOLOGICAL: Meningococcal polysaccharide diphtheria toxoid conjugate + Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed|BIOLOGICAL: Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Pembrolizumab in Subjects With Advanced Gastric or Gastroesophageal Junction Adenocarcinoma Who Progressed After First-Line Therapy With Platinum and Fluoropyrimidine: Integration of Molecular Subtypes Through Integrative Genomic Analysis
Status: COMPLETED
Conditions: Gastric Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of Ampicillin/Sulbactam Versus Moxifloxacin in the Treatment of Complicated Intra-abdominal Infections
Status: COMPLETED
Conditions: Intra-abdominal Infection
Interventions: DRUG: moxifloxacin|DRUG: ampicillin/sulbactam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Cost of Walking With Passive vs. Powered Prosthetic Knees Among Persons With Limb Loss
Status: RECRUITING
Conditions: Transfemoral Amputation
Interventions: OTHER: Powered Microprocessor-controlled Knee (PMPK)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bilateral Retromuscular Rectus Sheath Block Catheters Usage for Early Postoperative Analgesia After Laparotomic Gastrectomy.
Status: ACTIVE_NOT_RECRUITING
Conditions: Postoperative Pain
Interventions: PROCEDURE: Bilateral retromuscular rectus sheath block catheters usage for early postoperative analgesia after laparotomic gastrectomy.|DEVICE: Catheter insertion technique by using special tube t|PROCEDURE: Connection of catheters bilateraly to "easy pump" system,|DIAGNOSTIC_TEST: VAS scale for pain control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ribociclib and Aromatase Inhibitor in Treating Older Participants With Hormone Receptor Positive Metastatic Breast Cancer
Status: COMPLETED
Conditions: Estrogen Receptor and/or Progesterone Receptor Positive|HER2/Neu Negative|Stage IV Breast Cancer AJCC v6 and v7
Interventions: DRUG: Aromatase Inhibitor|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacokinetic Study|OTHER: Questionnaire Administration|DRUG: Ribociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Emotional Freedom Techniques (EFT) in Smokers Failing a Smoking Cessation Program
Status: RECRUITING
Conditions: Smoking
Interventions: BEHAVIORAL: EFT (Emotional Freedom Techniques)|BEHAVIORAL: CBT (Cognitive Behavioral Therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Efficacy of Vardenafil, Influence on Self-esteem and Self-confidence in Subjects With Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Levitra (Vardenafil, BAY38-9456)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Differentiation Therapy With Decitabine in Treating Patients With Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndromes|Myelodysplastic Syndromes|Refractory Anemia|Refractory Anemia With Excess Blasts|Refractory Anemia With Ringed Sideroblasts|Refractory Cytopenia With Multilineage Dysplasia|Thrombocytopenia
Interventions: OTHER: flow cytometry|OTHER: DNA methylation analysis|OTHER: cytogenetic analysis|DRUG: decitabine|GENETIC: microarray analysis|GENETIC: gene expression analysis|OTHER: pharmacological study|GENETIC: polymorphism analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carcinogenicity Study of Bupropion
Status: COMPLETED
Conditions: Depressive Disorder|Cancer
Interventions: DRUG: Regular bupropion use|DRUG: Regular SSRI (Selective serotonin reuptake inhibitors) use|DRUG: Regular TCA (Tricyclic antidepressants) use|DRUG: Regular use of any other antidepressant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of Emotion Regulation for Inappropriate Anger Expression
Status: COMPLETED
Conditions: Inappropriate Anger Expression
Interventions: BEHAVIORAL: Internet-delivered emotional awareness training|BEHAVIORAL: Internet-delivered Cognitive reappraisal training|BEHAVIORAL: Internet-delivered awareness and reappraisal training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser and Therapeutic Ultrasound in the Management of the Chronic Non-specific Low Back Pain
Status: UNKNOWN
Conditions: Chronic Low Back Pain
Interventions: OTHER: continuous ultrasound group|OTHER: pulsed ultrasound group|OTHER: low level laser therapy group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Education and Relaxation Program on Migraine Related Disability in Patients Attending Headache Clinic
Status: UNKNOWN
Conditions: Migraine Headache
Interventions: BEHAVIORAL: education and relaxation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE