pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Percutaneous Tibial Nerve Stimulation - an Alternative Treatment Option for Chronic Therapy Resistant Anal Fissure
Status: COMPLETED
Conditions: Chronic Anal Fissure
Interventions: PROCEDURE: Percutaneous tibial nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Polymerase Chain Reaction (PCR) Analysis of Nasal Polyps for Fungal DNA
Status: COMPLETED
Conditions: Sinusitis|Nasal Polyps
Interventions: PROCEDURE: Nasal swab under endoscopic guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Use of NPH Versus Basal Bolus Insulin for Steroid Induced Hyperglycemia
Status: TERMINATED
Conditions: Hyperglycemia Steroid-induced|Insulin Resistance, Diabetes
Interventions: DRUG: NPH Insulin|DRUG: glargine|DRUG: Insulin Aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise Training, Cognition, and Mobility in Older Adults With Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Older Adults|Multiple Sclerosis|Cognitive Impairment|Walking Impairment
Interventions: BEHAVIORAL: Aerobic and Resistance Exercise Program (GEMS program)|BEHAVIORAL: Flexibility and Stretching Program (FLEX-MS program)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Lumbar Drain to Remove Clots in Patients Admitted to the Neuro-ICU After Subarachnoid Hemorrhage.
Status: UNKNOWN
Conditions: Subarachnoid Hemorrhage.
Interventions: PROCEDURE: Lumbar drain|PROCEDURE: Ventricular drain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sesame Oil Cake Extract on Improvement of Cognitive Function
Status: COMPLETED
Conditions: Cognitive Function
Interventions: DIETARY_SUPPLEMENT: Sesame Oil Cake Extract|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Chemotherapy Omission in ER+/HER2- Breast Cancer With 1-3 Positive Lymph Nodes Receiving Extended Adjuvant Abemaciclib
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: 3-year abemaciclib without chemo|DRUG: treatment of physician's choice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Hyperlipidemia Combined With Carotid Atherosclerosis With ShenJu Granules
Status: RECRUITING
Conditions: Hyperlipidemia|Carotid Atherosclerosis
Interventions: OTHER: ShenJu|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy With or Without Polysaccharide-K in Patients With Stage IV HER2 Positive Breast Cancer Receiving HER2-Targeted Monoclonal Antibody Therapy
Status: COMPLETED
Conditions: HER2/Neu Positive|Recurrent Breast Carcinoma|Stage IV Breast Cancer
Interventions: BIOLOGICAL: HER-2/neu Intracellular Domain Protein|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pertuzumab|OTHER: Placebo|BIOLOGICAL: Polysaccharide-K|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Band Ligation (EBL) Versus Endoscopic Band Ligation and Propranolol for the Prevention of Variceal Rebleeding
Status: UNKNOWN
Conditions: Cirrhosis|Variceal Bleeding
Interventions: PROCEDURE: endoscopic band ligation|PROCEDURE: EBL+Propranolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Olanzapine for the Treatment of Chronic Nausea and/or Vomiting in Advanced Cancer Patients
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DRUG: Olanzapine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lisofylline as Continuous Subcutaneous and Intravenous Administration in Subjects With Type 1 Diabetes Mellitus
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Lisofylline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study on Therapeutic Effect of Combination of Envafolimab, Lenavatinib and TACE in Advanced HCC Patients
Status: COMPLETED
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DRUG: Envafolimab|PROCEDURE: TACE|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Omega Three Fatty Acids on Vascular Function in HIV
Status: COMPLETED
Conditions: High Triglyceride Level|HIV Infection
Interventions: DRUG: Lovaza
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-significant Risk (NSR) Study of [68Ga]-PSMA-11 (Illuccix) as a BgRT BioGuide on RefleXion X1
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: PET-CT imaging subsystem of the RefleXion X1 System Device
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Study of Neoadjuvant Chemotherapy and Immunotherapy Combined With Probiotics in Patients With Potential/Resectable NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer Stage III
Interventions: DRUG: nivolumab 4.5mg/kg+Paclitaxel (albumin-bound type) 260mg / m2+ Carboplatin AUC5
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of Electrochemotherapy in the Treatment of Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma
Interventions: DEVICE: Electroporation|DRUG: gemcitabine|DRUG: nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Orelabrutinib Plus Rituximab Followed by Maintenance With Orelabrutinib for Relapsed and Refractory Follicular Lymphoma(RR FL)
Status: UNKNOWN
Conditions: Follicular Lymphoma|Relapsed and Refractory Follicular Lymphoma
Interventions: DRUG: Orelabrutinib and Rituximab|DRUG: Orelabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omarigliptin (MK-3102) Clinical Trial - Placebo- and Sitagliptin-Controlled Monotherapy Study in Japanese Patients With Type 2 Diabetes Mellitus (MK-3102-020)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Omarigliptin|DRUG: Sitagliptin|DRUG: Placebo to omarigliptin|DRUG: Placebo to sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of the Efficacy of SPR-G Barrier Coat Versus Fluoride Varnish Versus MI Paste in the Treatment of Early White Spot Lesions in Pediatric Patients
Status: UNKNOWN
Conditions: White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Interventions: DRUG: PRG Barrier Coat|DRUG: Fluoride varnish|DRUG: MI paste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Tolerability, Safety and Efficacy of the H1-coil Deep Transcranial Magnetic Stimulation in Subjects With Negative Symptoms and Cognitive Deficits of Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DEVICE: H1 deep TMS coil|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bone Turnover in Type 2 Diabetes Patients
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: Sitagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Methodology Study in Healthy Subjects to Evaluate the Effect of AZD8309 After Nasal Administration of Lipopolysaccharide (LPS)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD8309|DRUG: AZD8309
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Polypharmacy in Clozapine-resistant Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: olanzapine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-intensity Interval, Low Volume Training in Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome|Insulin Resistance
Interventions: BEHAVIORAL: HIIT-LV|BEHAVIORAL: CAE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of FMT for the Treatment of IBS-D and Mental Health Comorbidity in Young Adults
Status: NOT_YET_RECRUITING
Conditions: Irritable Bowel Syndrome With Diarrhea|Fecal Microbiota Transplantation|Mental Health Issue
Interventions: PROCEDURE: Fecal Microbiota Transplantation|PROCEDURE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diaphragm Sparing Effect of Subomohyoid Block With Infraclavicular or Subscapularis Blocks in Comparison With Interscalen Block for Postoperative Analgesia in Shoulder Surgeries
Status: RECRUITING
Conditions: Shoulder Surgeries Operations
Interventions: PROCEDURE: diaghragm affection by ultrasound before and after the blocks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Atacicept in Combination With Rituximab in Subjects With Rheumatoid Arthritis (August III)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Rituximab|DRUG: Atacicept|DRUG: Placebo matched to atacicept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selumetinib in Treating Patients With Locally Advanced or Metastatic Liver Cancer
Status: COMPLETED
Conditions: Adult Primary Hepatocellular Carcinoma|Advanced Adult Primary Liver Cancer|Localized Unresectable Adult Primary Liver Cancer|Recurrent Adult Primary Liver Cancer
Interventions: DRUG: selumetinib|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Protective Ventilation and Postoperative Pulmonary Complications
Status: COMPLETED
Conditions: Complication of Ventilation Therapy|Postoperative Respiratory Complications
Interventions: OTHER: Maximal Compliance|OTHER: Transpulmonary Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Statins for Acutely Injured Lungs From Sepsis
Status: TERMINATED
Conditions: Sepsis|Acute Lung Injury
Interventions: DRUG: Rosuvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Thoracic Paravertebral Block in the Reduction of Acute Post-surgical Pain in Patients With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: Thoracic Paravertebral Block|PROCEDURE: Surgical Wound Infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Implementation of a Mindfulness Intervention for Depressive Symptoms Among Adults in a FQHC
Status: COMPLETED
Conditions: Depressive Symptoms|Stress, Psychological|Stress, Physiological
Interventions: BEHAVIORAL: mindfulness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-frequency Electrical Muscle Stimulation vs Cycle Training During Haemodialysis
Status: COMPLETED
Conditions: Kidney Failure, Chronic
Interventions: OTHER: Intra-dialytic LF-EMS|OTHER: Intra-dialytic cycle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Combination Aliskiren/Amlodipine in Patients With Hypertension Not Adequately Responding to Amlodipine Alone
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Amlodipine 10 mg|DRUG: Aliskiren 150|DRUG: Amlodipine 300
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ablation of Oligometastasis Combined With Lenvatinib and PD-1 Inhibitor for Advanced Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Advanced Hepatocellular Carcinoma|Oligometastasis|Ablation|Anti-PD1 Antibody|Lenvatinib
Interventions: PROCEDURE: ablation of oligometastasis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact Evaluation of Agribusiness Support and Nutrition Services Projects in Upper Egypt
Status: WITHDRAWN
Conditions: Poverty, Low Income, Food Insecurity, Undernutrition
Interventions: OTHER: FAS program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Strength and Coordination Training on Biomechanics and Injury in New Runners
Status: COMPLETED
Conditions: Injuries|Patellofemoral Pain Syndrome|Iliotibial Band Syndrome
Interventions: BEHAVIORAL: Strength and Coordination Training|BEHAVIORAL: Walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness and Tolerability of LabiaStick#01 in Subjects With Symptomatic Non-hypertrophic Chronic Vulvar Dermatoses
Status: TERMINATED
Conditions: Chronic Disease of Skin
Interventions: DEVICE: LabiaStick#01
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Troriluzole or Placebo Plus Ipi Plus Nivo in Mel Brain Mets
Status: TERMINATED
Conditions: Melanoma|Metastatic Melanoma
Interventions: DRUG: Ipilimumab|DRUG: Nivolumab|DRUG: Troriluzole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of FLEXOFYTOL® Versus PLACEBO
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: FLEXOFYTOL®|OTHER: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Single-dose Ketamine for the Reduction of Pain and Depression in the Emergency Department
Status: WITHDRAWN
Conditions: Acute Pain|Depression
Interventions: DRUG: Ketamine|DRUG: Midazolam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Diabetes Distress Using Cognitive Behavioral Therapy in Young Adults With Type 1 Diabetes
Status: RECRUITING
Conditions: Type 1 Diabetes
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Diabetes Distress (CBT-DD) with Continuous Glucose Monitoring|DEVICE: Continuous Glucose Monitoring (CGM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Pegilodecakin (LY3500518) With FOLFOX Compared to FOLFOX Alone Second-line Tx in Participants With Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: Pegilodecakin|DRUG: FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apalutamide, Abiraterone Acetate, and Prednisone in Treating Participants With Metastatic Castration Resistant Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Castration-Resistant Prostate Carcinoma|Prostate Adenocarcinoma Without Neuroendocrine Differentiation|Stage IV Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8|Stage IVB Prostate Cancer AJCC v8
Interventions: DRUG: Abiraterone Acetate|DRUG: Apalutamide|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-strain Synbiotic Versus a Multi-strain Probiotic in Premature Infants
Status: WITHDRAWN
Conditions: Feeding; Difficult, Newborn|Necrotizing Enterocolitis
Interventions: DIETARY_SUPPLEMENT: Multi-strain Probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Serum Folic Acid Status, Genotyping MTHFR 677C-->T, Plasma Homocysteine, DNA Methylation of IGF2 Gene and Microbiota of the Children: Mother-Children Cohort Study
Status: COMPLETED
Conditions: Folic Acid Deficiency
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Radial Extracorporeal Shock Wave Treatment for Chronic Plantar Fasciopathy
Status: COMPLETED
Conditions: Fasciitis, Plantar
Interventions: DEVICE: ESWT|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7496353 in Combination With a Checkpoint Inhibitor With or Without Standard-of-Care Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Metastatic Solid Tumor|Non-small Cell Lung Cancer|Gastric Cancer|Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: RO7496353|DRUG: Atezolizumab|DRUG: Capecitabine|DRUG: S-1|DRUG: Nivolumab|DRUG: Oxaliplatin|DRUG: Nab-paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Morphine Analgesia vs. Continuous Epidural Analgesia vs. Systemic Analgesia in Colorectal Surgery.
Status: COMPLETED
Conditions: Analgesia, Patient-Controlled|Epidural Analgesia|Anesthesia; Spinal|Morphine|Surgery, Colorectal|Intravenous Drug Delivery Systems
Interventions: DRUG: Morphine intrathecal|DRUG: Bupivacaine + Sufentanil epidural|DRUG: Morphine intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal Ophthalmic Imaging
Status: UNKNOWN
Conditions: Retinitis Pigmentosa|Maculopathy, Age Related|Macular Dystrophy|Macular Edema|Retinal Detachment|Retinal Degeneration|Glaucoma|Vascular Inflammation|Hypertension|Stroke|Diabetes|Corneal Dystrophy|Keratoconus|Dry Eye|Trauma
Interventions: DEVICE: High-resolution retinal imaging through adaptive optics|DEVICE: High-resolution retinal imaging through holographic systems
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Group-integrated Cognitive Behavioural Therapy (Gi-CBT) to Aid Communities' Reintegration of Former Terrorists in Nigeria: A Randomised Control Trial
Status: NOT_YET_RECRUITING
Conditions: Depression|Trauma|Anxiety|Fear
Interventions: BEHAVIORAL: Gi-CBT|OTHER: Media Orientation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupoint Focused Ultrasound Versus Laserpuncture In Mechanical Neck Pain
Status: NOT_YET_RECRUITING
Conditions: Neck Pain
Interventions: OTHER: Acupoint focused ultrasound|OTHER: Laserpuncture|OTHER: conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of an Innovative Digital Therapeutic for Smoking Cessation With Biochemical Verification
Status: WITHDRAWN
Conditions: Nicotine Addiction|Drug Addiction|Drug Dependence|Substance Use Disorder|Tobacco Dependence
Interventions: DEVICE: Treatment A with device Clickotine® (Active intervention)|DEVICE: Treatment B with smoking education (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Whey and Soy Protein Supplementation in Football Players
Status: COMPLETED
Conditions: Skeletal Muscle Damage|Muscle Damage|Athletic Performance
Interventions: DIETARY_SUPPLEMENT: Whey protein|DIETARY_SUPPLEMENT: Soy protein|DIETARY_SUPPLEMENT: Placebo (maltodextrin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Investigate Atezolizumab Subcutaneous in Patients With Previously Treated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Atezolizumab|DRUG: rHuPH20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Intratumoral Ipilimumab and TLR4 Agonist GLA-SE in Combination With Systemic Nivolumab and Chemotherapy
Status: WITHDRAWN
Conditions: Colorectal Cancer Metastatic
Interventions: DRUG: FOLFOX regimen|DRUG: Nivolumab|DRUG: Ipilimumab|DRUG: GLA-SE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deep Breathing Techniques (Pranayama) in Pregnancy
Status: RECRUITING
Conditions: Pregnancy Related|Hypertension in Pregnancy|Blood Pressure
Interventions: BEHAVIORAL: Alternate Nostril Breathing|BEHAVIORAL: Bhramari Breathing|BEHAVIORAL: Sheetali Breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Vitamin D for Women at Increased Risk of Developing Ovarian, Fallopian, or Primary Peritoneal Cancer
Status: TERMINATED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Cancer
Interventions: DIETARY_SUPPLEMENT: Arm A: Vitamin D3 Group|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial of TQB2618 Injection Combined With Penpulimab Injection and Chemotherapy Versus Penpulimab Injection Combined With Chemotherapy in First-line Treatment of Relapsed/Metastatic Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Recurrent Squamous Cell Carcinoma of the Head and Neck|Metastatic Squamous Cell Carcinoma
Interventions: DRUG: TQB2618 injection, Penpulimab injection, Paclitaxel, Cisplatin or Carboplatin|DRUG: Penpulimab injection, Paclitaxel, Cisplatin or Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Investigate Effect of Macitentan on Riociguat Pharmacokinetics
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Riociguat (Adempas)|DRUG: Macitentan (Opsumit)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Early Initiation of Butylphthalide Treatment in Patients With Acute Ischemic Stroke.
Status: NOT_YET_RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: BEHAVIORAL: Butylphthalide treatment initiation time
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Internet Technology Based Life-style and Care Intervention for Risk Factors of Non Communicable Diseases（NCD）
Status: RECRUITING
Conditions: Lifestyle Intervention|Non Communicable Diseases
Interventions: BEHAVIORAL: Intensive intervention group|BEHAVIORAL: standard intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Project Frazier 3 Regulatory Clinical Evaluation
Status: COMPLETED
Conditions: Diabetes Mellitus|Healthy Volunteers
Interventions: DEVICE: Frazier 3 Verio|DEVICE: Frazier 3 UltraPlus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Chronic Total Occlusion Registry
Status: TERMINATED
Conditions: Coronary Occlusion|Coronary Artery Stenosis|Coronary Stenosis
Interventions: PROCEDURE: Percutaneous coronary intervention|PROCEDURE: Coronary Artery Bypass Grafting|DRUG: Medical treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Erector Spinae Plane (ESP) Block With 20 ml Versus 30 ml in Cardiac Surgery
Status: COMPLETED
Conditions: Cardiac Surgery|Postoperative Pain
Interventions: PROCEDURE: bilateral erector spinae plane block with 30 mL 0.25 % bupivacaine|PROCEDURE: bilateral erector spinae plane block with 20 mL 0.25 % bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lifestyle MIND- Feasibility of Wait-list Control
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes Mellitus|Serious Mental Illness|Schizophrenia|Major Depression|Bipolar Disorder
Interventions: BEHAVIORAL: Lifestyle MIND
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapy of Atrial Flutter by Afib Ablation
Status: UNKNOWN
Conditions: Atrial Fibrillation|Atrial Flutter
Interventions: DRUG: Antiarrhythmic drug|PROCEDURE: Cavo-tricuspid-isthmus-ablation|PROCEDURE: Pulmonary vein isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chiropractic and Exercise for Seniors With Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: PROCEDURE: Chiropractic Manual treatment + home exercise (procedure+behavior)|PROCEDURE: Supervised rehabilitative exercise+home exercise|BEHAVIORAL: Home exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determination of Liver Stiffness in Chronic Liver Disease Patients by Acoustic Radiation Force Imaging (ARFI) Ultrasound
Status: COMPLETED
Conditions: Chronic Liver Disease
Interventions: DEVICE: Acoustic Radiation Force Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Functional Near-Infrared Spectroscopy (fNIRS) Combined With Diffuse Correlation Spectroscopy (DCS) in Neurocognitive Disease as Compared to Healthy Neurotypical Controls
Status: RECRUITING
Conditions: Juvenile Neuronal Ceroid Lipofuscinosis|Smith-Lemli-Opitz Syndrome|Creatine Transporter Deficiency|Niemann-Pick Disease Type C1
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Abdominal Surgery Study Of GSK576428 (Fondaparinux Sodium)In Japanese Patients
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: Fondaparinux sodium|DRUG: GSK576428
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Use of FACT-GOG/NTX Questionnaire in Peripheral Neurotoxicity & Validation of a French Version of This Questionnaire
Status: COMPLETED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Neoplasms
Interventions: DRUG: Paclitaxel|DRUG: EPO
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Circulating Tumor DNA Guided Adjuvant Chemotherapy for Biliary Tract Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Biliary Tract Cancer
Interventions: DRUG: S-1(Intravenous combined with oral)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NOn-invasive Repeated THerapeutic STimulation for Aphasia Recovery
Status: COMPLETED
Conditions: Aphasia
Interventions: DEVICE: rTMS|DEVICE: tDCS|DEVICE: Sham rTMS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of AQW051 in L-dopa Induced Dyskinesias in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Dyskinesias|Drug-induced
Interventions: DRUG: AQW051|DRUG: AQW051|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of MCI-186 in Subjects With Acute Ischemic Stroke
Status: COMPLETED
Conditions: Acute Ischemic Stroke (AIS)
Interventions: DRUG: MCI-186|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Leg Elevation and Leg Wrapping in the Prevention of Propofol Induced Hypotension
Status: UNKNOWN
Conditions: Propofol Induced Hypotension
Interventions: OTHER: leg elevation|OTHER: leg wrapping|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Oral Androgens in Man-3 (ORAL T-3) Pharmacokinetics of Oral Testosterone
Status: COMPLETED
Conditions: Contraception|Hypogonadism
Interventions: DRUG: Oral Testosterone|DRUG: Leuprolide (Lupron)|DRUG: Dutasteride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Innovations in Biofeedback and Its Use in Mental Health
Status: WITHDRAWN
Conditions: Anxiety|Biofeedback, Psychology
Interventions: DEVICE: Biofeedback plus gaming (Nevermind)|DEVICE: Biofeedback only (The Pip)|BEHAVIORAL: Relaxation training|BEHAVIORAL: Gaming only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Krill Oil on Cognitive Function in Adults
Status: COMPLETED
Conditions: Subjective Memory Impairment
Interventions: DIETARY_SUPPLEMENT: Krill oil group|DIETARY_SUPPLEMENT: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of Visual Outcome of Two Extended Depth of Focus Intraocular Lenses After Cataract Surgery
Status: RECRUITING
Conditions: Visual To Compare the Visual Outcome Between AcrySof™ IQ Vivity™ and TECNIS Synergy™ Intraocular Lens (Model ZFR00V )
Interventions: DEVICE: IOL implantation|DEVICE: IOL implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Caudal Volumes on the Anatomical Spread of Caudals in Children
Status: COMPLETED
Conditions: Asa 1 and 2 Patients for Elective Surgery Requiring Caudal as Part of Their Care
Interventions: DRUG: caudal volume 1|BIOLOGICAL: caudal volume 2|DRUG: caudal volume 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of LNK01001 Capsule in Patients With Moderate to Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: LNK01001 Dose A|DRUG: LNK01001 Dose B|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating The Effect of Bosutinib (SKI-606) On Cardiac Repolarization (Rhythms Of The Heart)
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: SKI-606|DRUG: Placebo|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Value of hPG80 (Circulating Progastrin) for the Diagnosis of Neuroendocrine Tumours in Patients With an MEN1 Mutation
Status: RECRUITING
Conditions: Neuroendocrine Tumors|MEN1 Mutation
Interventions: BIOLOGICAL: blood sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetic Study Investigating the Extent of Paracetamol Absorption From a New Formulation of Paracetamol Compared With Panadol® Extend
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Marketed paracetamol|DRUG: Experimental paracetamol formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Study of Low-Magnitude, High-Frequency Vibration Treatment on Osteoporotic Hip Fracture Healing
Status: COMPLETED
Conditions: Hip Fracture
Interventions: DEVICE: Low-magnitude high - frequency vibration treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemoradiotherapy in Patients With Localised Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Carcinoma
Interventions: DRUG: Vinorelbine|RADIATION: High dose Radiotherapy|DRUG: Gemcitabine|DRUG: Cisplatin|RADIATION: High Dose Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UNITY-B A Prospective, Multicentric, Single-arm Study to Evaluate the Safety and Efficacy of the UNITY-B Biodegradable Balloon-Expandable Biliary Stent System in Subjects With Biliary Strictures
Status: RECRUITING
Conditions: Biliary Obstruction|Bile Duct Stricture|Bile Duct Diseases
Interventions: DEVICE: Biliary Duct Stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Blended Intervention for Adjustment Disorder.
Status: RECRUITING
Conditions: Adjustment Disorders
Interventions: BEHAVIORAL: • Blended treatment for AjD combining a self-applied Internet-based program (TAO) with face-to-face sessions via videoconference.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of an Evidence-based Stepped Care System for Alcohol and Other Drug Use Problems Among Congolese Refugees in Zambia
Status: ACTIVE_NOT_RECRUITING
Conditions: Alcohol and Substance-Related Mental Disorders
Interventions: BEHAVIORAL: SBIRT|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Couples-based Behavioral Psychotherapy for Male Patients With Posttraumatic Stress Disorder and Alcohol Dependence
Status: WITHDRAWN
Conditions: PTSD|Alcohol Dependence
Interventions: BEHAVIORAL: Couples-based behavioral psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outpatient Administration of R-DHAP in Relapsed/Refractory Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Relapsed Non Hodgkin Lymphoma|Refractory Non-Hodgkin Lymphoma
Interventions: DRUG: Rituximab|DRUG: Carboplatin|DRUG: Cytarabine Injection|DRUG: Dexamethasone|DRUG: Filgrastim 0.3 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Bendamustine in the Treatment of Chinese Participants With Indolent Non-Hodgkin Lymphoma Refractory to Rituximab Treatment
Status: COMPLETED
Conditions: Non-Hodgkin Lymphoma
Interventions: DRUG: Bendamustine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clear Aligner Treatment With and Without Low Level Laser Therapy for Upper Incisor Crowding
Status: COMPLETED
Conditions: Crowding of Anterior Maxillary Teeth
Interventions: PROCEDURE: Clear Aligner Treatment|PROCEDURE: Low level laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Investigate the Effectiveness of KEFPEP® on Regulating High Blood Pressure
Status: COMPLETED
Conditions: Prehypertension
Interventions: DIETARY_SUPPLEMENT: KEFPEP®|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Usefulness of Topical Non-Steroidal Anti-Inflammatory Drugs or Steroids Before Trabeculectomy and Clinical Outcomes
Status: COMPLETED
Conditions: Glaucoma|Trabeculectomy|Fibrosis|Intraocular Pressure
Interventions: DRUG: ketorolac acetate|DRUG: fluorometholone|DRUG: artificial lacrimal tears
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Randomized Controlled Study of Rolapitant for the Prevention of Nausea and Vomiting Following Surgery (Study P04937AM1)(COMPLETED)
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Rolapitant Dose 1|DRUG: Rolapitant Dose 2|DRUG: Rolapitant Dose 3|DRUG: Rolapitant Dose 4|DRUG: Ondansetron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating the Effects of Multiple Doses of NSA-789 in Subjects With Schizophrenia or Schizoaffective Disorder
Status: WITHDRAWN
Conditions: Schizophrenia
Interventions: DRUG: NSA-789|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: OTHER
Clinical trial: Effect of Propofol-Dexmedetomidine on Cerebral Oxygenation and Metabolism During Brain Tumor Resection
Status: COMPLETED
Conditions: Brain Tumor|Surgery
Interventions: DRUG: Propofol-Dexmedetomidine group|DRUG: Sevoflurane group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ACTIVE: Activity Therapy to Increase Veteran Engagement
Status: ACTIVE_NOT_RECRUITING
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: Behavioral Activation|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Myeloablative Consolidation Therapy and Tandem Autologous Stem Cell Rescue in Patients With High-Risk Neuroblastoma
Status: RECRUITING
Conditions: Neuroblastoma
Interventions: DRUG: Thiotepa|DRUG: Cyclophosphamide|DRUG: Melphalan|DRUG: Etoposide|DRUG: Carboplatin|BIOLOGICAL: Autologous Stem Cell Infusion|BIOLOGICAL: Granulocyte colony stimulating factor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Bevacizumab for Inflammatory Neovascular Membranes
Status: WITHDRAWN
Conditions: Vogt Koyanagi Harada Disease|Serpiginous Choroiditis|Multifocal Choroiditis
Interventions: DRUG: Bevacizumab|PROCEDURE: Intravitreal Injection of Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rezum for 30-80ml Patients With Moderate-severe LUTS to Study Surgical Principles for Median Lobe Enlargement
Status: RECRUITING
Conditions: Prostatic Hyperplasia of the Medial Lobe
Interventions: DEVICE: Rezum®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irinotecan and Celecoxib in Treating Patients With Unresectable or Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Diarrhea
Interventions: DRUG: celecoxib|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Merlin (Ethanol and Glycolic Acid Mixture) for the Treatment of Cold Sores
Status: COMPLETED
Conditions: Recurrent Herpes Labialis
Interventions: DRUG: ethanol/glycolic acid solution|DRUG: Placebo/Ethanol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Different Mucoactive Agents for the Care of the Intubated Patient in a Surgical Trauma Intensive Care Unit
Status: COMPLETED
Conditions: Mucus Obstruction|Intubation
Interventions: DRUG: mucomyst|DRUG: sodium chloride (saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: ACZ885 in Type 1 Diabetes Mellitus
Status: WITHDRAWN
Conditions: Diabetes Mellitus|Diabetes Type 1
Interventions: DRUG: ACZ885|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Aging|Diabetes Mellitus, Type 2|PreDiabetes|Overweight and Obesity
Interventions: DRUG: Semaglutide Injectable Product|BEHAVIORAL: Lifestyle Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess Cardiac Conduction of GSK1349572
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: GSK1349572 250 mg|DRUG: Placebo Suspension|DRUG: Moxifloxacin 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of High Protein Diet Versus GFR Based Protein Diet in Heart Failure Patients With Renal Insufficiency
Status: UNKNOWN
Conditions: Heart Failure With Reduced Ejection Fraction|Renal Insufficiency
Interventions: OTHER: protein intake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pelvic Drain After Rectal Resection for Mid-low Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: PROCEDURE: Pelvic drain|OTHER: No pelvic drain is placed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot and Feasibility of MEMI for Chronic Traumatic Brain Injury
Status: ENROLLING_BY_INVITATION
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: MEMI (Memory Ecological Momentary Intervention) Spaced Retrieval|BEHAVIORAL: Blocked Retrieval
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Geographically Clustered Mailing of Fecal Immunochemical Test (FIT) Kits
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: OTHER: Usual Care FIT Screening Strategy|OTHER: GeoMail FIT Screening Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Intestinal Permeability in Obesity
Status: TERMINATED
Conditions: Obesity|Metabolic Diseases|Nutrition Disorders|Body Weight
Interventions: PROCEDURE: Intestinal permeability|OTHER: a solution of mannitol and lactitol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Assess the Effects of PTC857 Treatment in Participants With Amyotrophic Lateral Sclerosis ALS
Status: ACTIVE_NOT_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: PTC857|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT