pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Single Dose Study To Test Two Pediatric Forms Of Ritlecitinib Compared With Adult Ritlecitinib In Healthy Adults
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: ritlecitinib|DRUG: ritlecitinib|DRUG: ritlecitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Chronic Leg Ulcer in Outpatient's Department and i Primary Care - Wound Size and Inflammation
Status: UNKNOWN
Conditions: Treatment of Leg Ulcer|Sharp Debridement|Proinflammatory Cytokines
Interventions: PROCEDURE: Sharp debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GD2-CAR T Cells for Pediatric Brain Tumours
Status: RECRUITING
Conditions: Brain Tumor, Pediatric|Medulloblastoma, Childhood|Embryonal Tumor|High Grade Glioma|Diffuse Midline Glioma|Diffuse Intrinsic Pontine Glioma|Brain Tumor Adult
Interventions: BIOLOGICAL: GD2-CART01 (iC9-GD2-CAR T-cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SEGATROM: Sensory and Gastrointestinal Impact of Taste Receptor Variants on Human Metabolism and Nutrition
Status: COMPLETED
Conditions: Disorder of Glucose Regulation
Interventions: DIETARY_SUPPLEMENT: sweet block|DIETARY_SUPPLEMENT: bitter block|DIETARY_SUPPLEMENT: umami-block|OTHER: gastroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Perineural Low-dose Dexamethasone Added to Infraclavicular Block Anesthesia
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Dexamethasone|DRUG: Ropivacaine|DRUG: Paracetamol|DRUG: Morphine|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prehabilitation Exercise Plus Perioperative Optimization of Senior Health
Status: TERMINATED
Conditions: Cognitive Decline|Age-Related Memory Disorders|Postoperative Complications|Age-Related Atrophy|Postoperative Cognitive Dysfunction
Interventions: OTHER: Exercise Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Abatacept Costimulatory Blockade in the Treatment of Alopecia Totalis/Universalis
Status: WITHDRAWN
Conditions: Alopecia Totalis/Universalis
Interventions: DRUG: Abatacept|DRUG: Inactive infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of AMG 557 in Subjects With Subacute Cutaneous Lupus Erythematosus
Status: TERMINATED
Conditions: Cutaneous Lupus|Lupus
Interventions: DRUG: AMG 557|DRUG: AMG 557 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Online Training Program Model for Effective Management of Nursing Services in Times of Crisis Such as Pandemic
Status: COMPLETED
Conditions: Pandemics|Crisis State|Nursing|Education
Interventions: OTHER: Structured online training program for effective management of nursing services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy of PegIntron and Rebetol Combination Therapy in Patients With Chronic Hepatitis C in Japan (Study P04505)
Status: COMPLETED
Conditions: Hepatitis C, Chronic|Hepatitis C
Interventions: DRUG: peginterferon alfa-2b|DRUG: ribavirin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunogenicity and Reactogenicity of a Meningococcal B Outer Membrane Vesicle Vaccine Given in a 0,6,12 Month Schedule to Health UK Adults
Status: COMPLETED
Conditions: Neisseria Meningitidis
Interventions: BIOLOGICAL: Meningococcal outer membrane vesicle vaccine "MenBVac"
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of SR-T100 Gel in Common Warts (CW) Patients
Status: SUSPENDED
Conditions: Common Wart
Interventions: DRUG: Vehicle gel|DRUG: SR-T100 gel with 1.0% of SM|DRUG: SR-T100 gel with 2.3% of SM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Patient Protocol for an NRG1 Fusion Positive Metastatic Pancreatic Cancer Patient Using Seribantumab
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Seribantumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Ultrasound-guided Drainage of Walled Off Necrosis (WON)
Status: UNKNOWN
Conditions: Pancreatic Pseudocyst
Interventions: DEVICE: Lumen-apposing metal stent (LAMS)|DEVICE: Double pigtail plastic stent (DPPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anticipation Effect on Painful Phenomenons Linked to Rectal Distension for Patients With a Crohn's Disease in Remission
Status: UNKNOWN
Conditions: Crohn's Disease
Interventions: BEHAVIORAL: Psychological tests|DEVICE: Magnetic Resonance Imaging|BEHAVIORAL: Heart Rate Variability
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Contribution of Musculoskeletal Ultrasound to the General Practitioner's Overall Decision-making Strategy
Status: NOT_YET_RECRUITING
Conditions: Musculoskeletal; Anomaly
Interventions: OTHER: musculoskeletal ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neoadjuvant With Trastuzumab, Pyrotinib Plus Palbociclib and Fulvestrant in HER2-positive, ER-positive Breast Cancer
Status: RECRUITING
Conditions: Estrogen Receptor-positive Breast Cancer|HER2-positive Breast Cancer
Interventions: DRUG: Palbociclib|DRUG: trastuzumab|DRUG: pyrotinib|DRUG: fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Establish the Efficacy of QBX258 in Patients With Moderate to Severe Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: QBX258|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implicit Versus Explicit Motor Training for Upper Extremity Rehabilitation in Chronic Stroke Patients
Status: RECRUITING
Conditions: CVA (Cerebrovascular Accident)
Interventions: OTHER: Implicit motor training program|OTHER: Explicit motor training program|OTHER: Selected physical therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Uterus Transplantation From a Multi-organ Donor
Status: RECRUITING
Conditions: Infertility, Female|Mayer Rokitansky Kuster Hauser Syndrome
Interventions: PROCEDURE: uterus transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Baclofen on Marijuana Withdrawal and Relapse
Status: COMPLETED
Conditions: Marijuana Dependence
Interventions: DRUG: Baclofen|DRUG: Marijuana|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Abatacept in Subjects With Chronic Urticaria Who Have Had an Inadequate Response to Anti-histamine Therapy
Status: COMPLETED
Conditions: Urticaria
Interventions: DRUG: abatacept (Orencia ®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dysport ® as an Adjunctive Treatment to Bracing in the Management of Adolescent Idiopathic Scoliosis
Status: RECRUITING
Conditions: Adolescent Idiopathic Scoliosis
Interventions: DRUG: AbobotulinumtoxinA|DRUG: Placebos|DEVICE: Custom Thoracolumbosacral Orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Acalabrutinib and Tafasitamab in MZL Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Marginal Zone Lymphoma
Interventions: DRUG: Tafasitamab|DRUG: Acalabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REBT Intervention Program for Career Decision-making Difficulties in High School Pupils
Status: COMPLETED
Conditions: Career Decision-making Difficulties|Worry|Psychological Distress
Interventions: BEHAVIORAL: REBT Career Intervention|BEHAVIORAL: Regular Career Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1a/1b Study of TPST-1495 as a Single Agent and in Combination With Pembrolizumab in Subjects With Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor|Colorectal Cancer|Non Small Cell Lung Cancer|Squamous Cell Carcinoma of Head and Neck|Urothelial Carcinoma|Endometrial Cancer|Gastroesophageal Junction Adenocarcinoma|Gastric Adenocarcinoma|Solid Tumors With PIK3Ca Mutation
Interventions: DRUG: TPST-1495 twice daily|DRUG: TPST-1495 once daily or on intermittent schedule|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insertion Distance of Thoracic Epidural Catheters in the Context of Thoracotomy Procedures.
Status: COMPLETED
Conditions: Pain
Interventions: OTHER: Thoracic epidural catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Anabolic Properties of Fortified Plant-based Protein in Older People
Status: RECRUITING
Conditions: Muscle Protein Synthesis|Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Fortified plant-based protein blend|DIETARY_SUPPLEMENT: Plant-based protein blend|DIETARY_SUPPLEMENT: Whey protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of High Doses of Radiation on Bone Structure and Metabolism
Status: COMPLETED
Conditions: Malignant Bone Tumors
Interventions: RADIATION: Radiation (Surgical Arm)|RADIATION: Radiation (Non-surgical Arm)|PROCEDURE: Malignant Tumor Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: VertebrOpLasty Versus Conservative Treatment in Acute Non Osteoporotic Vertebral Fractures
Status: COMPLETED
Conditions: Vertebral Compression Fracture|Spinal Trauma
Interventions: OTHER: vertebroplasty|OTHER: conservative therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of 15% Eflornithine Hydrochloride Cream on African-American Males With Pseudofolliculitis Barbae
Status: COMPLETED
Conditions: Pseudofolliculitis Barbae
Interventions: DRUG: 15% Eflornithine Hdyrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: ECT
Clinical trial: Study of the Safety of Trogarzo™ Administered as an Undiluted "IV Push" or an Intramuscular Injection
Status: COMPLETED
Conditions: HIV-1-infection
Interventions: DRUG: ibalizumab-uiyk
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: realMIND: Observational Study on Safety and Effectiveness of Tafasitamab in Combination With Lenalidomide in Patients With Relapsed or Refractory DLBCL
Status: RECRUITING
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: Tafasitamab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Triple Immune Checkpoint Inhibition for Advanced or Metastatic PD-(L)1 Refractory Merkel Cell Carcinoma
Status: RECRUITING
Conditions: Unresectable Clinical Stage III Merkel Cell Carcinoma AJCC v8|Clinical Stage IV Merkel Cell Carcinoma AJCC v8|Merkel Cell Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Retifanlimab|DRUG: Tuparstobart|DRUG: Verzistobart
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for Hospitalized Adult Patients With COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: REGN10933+REGN10987 combination therapy|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Inclination of the Proximal Tibiofibular Joint Surface and Medial Compartment Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DIAGNOSTIC_TEST: Standing anteroposterior knee radiographs and special proximal tibiofibular joint radiograph.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study With Wee-1 Inhibitor AZD1775 (MK-1775) and Carboplatin to Treat p53 Mutated Refractory and Resistant Ovarian Cancer
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer
Interventions: DRUG: MK-1775 and carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study to Evaluate the Effectiveness of EVT 302 in Smoking Cessation.
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: EVT 302|DRUG: Placebo|DRUG: EVT 302 plus open label Nicotine replacement|DRUG: Placebo plus open label Nicotine Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Clinical and Radiological Success of Vital Amputation Treatment
Status: UNKNOWN
Conditions: Endodontic Inflammation|Pulp Disease, Dental
Interventions: PROCEDURE: Control|PROCEDURE: NeoMTA Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Improving Treatment of Major Depressive Disorder by Reducing Negative Future-Oriented Mental Imagery
Status: RECRUITING
Conditions: Major Depressive Disorder|Mental Imagery|Cognitive Behavioral Therapy
Interventions: BEHAVIORAL: Future-oriented imagery rescripting|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Gemcitabine as Chemoradiotherapy in Patients With Locally Advanced Carcinoma of Cervix and Renal Disease
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic-pharmacodynamic Interaction Between Three Different Single Doses of BIA 9-1067 and a Single-dose of Immediate-release Levodopa/Benserazide
Status: COMPLETED
Conditions: Parkinson's Disease (PD)
Interventions: DRUG: BIA 9-1067|DRUG: Placebo|DRUG: Prolopa®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Apatinib and Etoposide Capsule Versus Weekly Paclitaxel in Patients With Platinum Resistant Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: DRUG: Apatinib|DRUG: Etoposide|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Navigation to Increase Participation and Diversity in Cancer Clinical Trials
Status: RECRUITING
Conditions: Breast Carcinoma|Digestive System Carcinoma|Genitourinary System Carcinoma
Interventions: OTHER: Best Practice|BEHAVIORAL: Patient Navigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Validation of Diagnostics to Identify Glucose-6-phosphate Dehydrogenase Activity in the US
Status: COMPLETED
Conditions: G6PD Deficiency
Interventions: DIAGNOSTIC_TEST: SD Biosensor G6PD Analyzer|DIAGNOSTIC_TEST: Pointe Scientific Test Kit|DIAGNOSTIC_TEST: HemoCue System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Safety and Efficacy of Needle-Free Injector and Insulin Pen in Patients With T2DM
Status: UNKNOWN
Conditions: T2DM (Type 2 Diabetes Mellitus)|Needle-free Injector|Time in Range
Interventions: DEVICE: Needle-free injector|DEVICE: Insulin pen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 177Lu-EB-PSMA617 in Patients With Metastatic Castration-resistant Prostate Cancer
Status: UNKNOWN
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: 177Lu-EB-PSMA-617
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SSAT064: Pharmacokinetics of Abacavir/Lamivudine/Dolutegravir in HIV Patients of 60 Years and Over
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Triumeq
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Adjuvant Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab for Resected High-Risk Melanoma in Participants With High-Risk Stage II-IV Melanoma (MK-7684A-010/KEYVIBE-010)
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: BIOLOGICAL: Pembrolizumab/Vibostolimab|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Initial Assessment of the Feasibility and Efficacy of a Scalable Digital CBT for Generalized Anxiety and Associated Health Behaviors in a Cardiovascular Disease Population
Status: RECRUITING
Conditions: Anxiety Disorders|Cardiovascular Diseases|Anxiety|Health Behavior
Interventions: BEHAVIORAL: Daylight dCBT Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis)
Status: RECRUITING
Conditions: Complicated Acute Appendicitis
Interventions: OTHER: No antibiotics|DRUG: Antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Study the Safety and Efficacy of SM-020 Gel 1.0% in Subjects With Seborrheic Keratoses and Non-Melanoma Skin Cancers
Status: RECRUITING
Conditions: Non-Melanoma Skin Cancers
Interventions: DRUG: SM-020 1% Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SRS (Stereotactic Radiosurgery) Plus Ipilimumab
Status: TERMINATED
Conditions: Newly Diagnosed Melanoma Metastases in the Brain and Spine
Interventions: PROCEDURE: Stereotactic Radiosurgery (SRS)|BIOLOGICAL: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erlotinib in Treating Patients With Advanced Non-Small Cell Lung Cancer, Ovarian Cancer, or Squamous Cell Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Recurrent Non-small Cell Lung Cancer|Recurrent Ovarian Epithelial Cancer|Recurrent Squamous Cell Carcinoma of the Hypopharynx|Recurrent Squamous Cell Carcinoma of the Larynx|Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity|Recurrent Squamous Cell Carcinoma of the Nasopharynx|Recurrent Squamous Cell Carcinoma of the Oropharynx|Stage III Squamous Cell Carcinoma of the Hypopharynx|Stage III Squamous Cell Carcinoma of the Larynx|Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage III Squamous Cell Carcinoma of the Nasopharynx|Stage III Squamous Cell Carcinoma of the Oropharynx|Stage IIIA Non-small Cell Lung Cancer|Stage IIIA Ovarian Epithelial Cancer|Stage IIIB Non-small Cell Lung Cancer|Stage IIIB Ovarian Epithelial Cancer|Stage IIIC Ovarian Epithelial Cancer|Stage IV Non-small Cell Lung Cancer|Stage IV Ovarian Epithelial Cancer|Stage IV Squamous Cell Carcinoma of the Hypopharynx|Stage IV Squamous Cell Carcinoma of the Nasopharynx|Stage IVA Squamous Cell Carcinoma of the Larynx|Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVA Squamous Cell Carcinoma of the Oropharynx|Stage IVB Squamous Cell Carcinoma of the Larynx|Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVB Squamous Cell Carcinoma of the Oropharynx|Stage IVC Squamous Cell Carcinoma of the Larynx|Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVC Squamous Cell Carcinoma of the Oropharynx
Interventions: DRUG: erlotinib hydrochloride|OTHER: pharmacological study|OTHER: pharmacogenomic studies|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ankle Syndesmosis Fixation by Antibiotic Releasing Bioabsorbable Screw
Status: COMPLETED
Conditions: Ankle Fracture
Interventions: PROCEDURE: A ciprofloxacin containing bioabsorbable PLGA bone screw
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Virtual Reality Platform Simulating Visual Impairment for Testing of Electronic Travel Aids and Performing Orientation and Mobility Training
Status: COMPLETED
Conditions: Visual Impairment|Age-Related Macular Degeneration|Diabetic Retinopathy|Glaucoma
Interventions: OTHER: In-House Developed VR Platform - AMD, DR, Glaucoma|OTHER: In-House Developed VR Platform - Glaucoma
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study of the Safety and Effectiveness of Ustekinumab (Stelara) in Chinese Patients With Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: placebo|DRUG: ustekinumab|DRUG: placebo|DRUG: ustekinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Left Celiac Plexus Resection for Pancreatic Cancer at the Body and Tail
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: PROCEDURE: Celiac plexus resection|PROCEDURE: Pancreatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Conventional With Stereotactic Radiotherapy for Pain Reduction and Quality of Life in Spinal Metastases
Status: TERMINATED
Conditions: Spinal Metastases
Interventions: RADIATION: conventional radiotherapy|RADIATION: stereotactic radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Stellate Ganglion Block in Control of Arrhythmia in Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Arrythmia|Pain, Acute
Interventions: PROCEDURE: right stellate ganglion block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Robotic-assisted Versus Conventional Laparoscopic Surgery in Obese Patients With Early Endometrial Cancer
Status: NOT_YET_RECRUITING
Conditions: Endometrial Cancer|Endometrial Neoplasms|Obesity, Morbid|Gynecologic Cancer|Gynecologic Disease
Interventions: PROCEDURE: Robot-assisted surgery|PROCEDURE: Laparoscopic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intrathecal Morphine on Chronic Pain After Elective Caesarean Section
Status: COMPLETED
Conditions: Chronic Pain Post-Procedural
Interventions: DRUG: Morphine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Osteopathic Manipulative Treatment (OMT) on the Golf Swing
Status: COMPLETED
Conditions: Manipulation, Osteopathic
Interventions: PROCEDURE: OMT (Osteopathic Manipulative Treatment)|PROCEDURE: Sham intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Omega 3 Fatty Acids and Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DIETARY_SUPPLEMENT: Hiomega-3 supplement of Naturalis® company -
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of Filgotinib on Semen Parameters in Adult Males With Active Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, or Non-radiographic Axial Spondyloarthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Psoriatic Arthritis|Ankylosing Spondylitis|Non-Radiographical Axial Spondyloarthritis
Interventions: DRUG: Filgotinib|DRUG: Placebo|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Gastric Cancer
Status: WITHDRAWN
Conditions: Advanced Gastric Cancer
Interventions: BIOLOGICAL: Activated CIK and CD3-MUC1 Bispecific Antibody in Treating Gastric cancer|PROCEDURE: Cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Gut Microbiome in FLT3- AL Undergoing Allo-HSCT With Or Without Sorafenib Maintenance
Status: RECRUITING
Conditions: Acute Leukemia|Allogeneic Hematopoietic Stem Cell Transplantation
Interventions: DRUG: Sorafenib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Study to Investigate the Potential Interactions Between Food and ACT-541468 and Between ACT-541468 and Midazolam
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Midazolam|DRUG: ACT-541468
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: VectorFlow Tunneled Dialysis Catheter (TDC) Versus Palindrome TDC
Status: COMPLETED
Conditions: Renal Failure Chronic Requiring Hemodialysis|Chronic Renal Insufficiency
Interventions: DEVICE: VectorFlow TDC|DEVICE: Palindrome TDC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of TET Enema in the Treatment of UC
Status: UNKNOWN
Conditions: Ulcerative Colitis Chronic Mild|Ulcerative Colitis Chronic Moderate
Interventions: DEVICE: The Colonic Transendoscopic enteral Tubing.|DRUG: Glutamine|DRUG: Mesalazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Study of the Feasibility of Early Lung Ultrasound in Neonatal Respiratory Distress in Premature Newborns Born Between 32 Weeks of Amenorrhea and 36 Weeks Plus 6 Days of Amenorrhea, Hospitalized in the Neonatal Pediatrics and Intensive Care Units of the Dijon University Hospital
Status: RECRUITING
Conditions: Neonatal Respiratory Distress|Preterm Birth
Interventions: PROCEDURE: Pulmonary ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Wellbutrin XL, Major Depressive Disorder and Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Major Depressive Disorder
Interventions: DRUG: bupropion extended release (Wellbutrin XL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bicycle Ergometer Training in Duchenne Muscular Dystrophy
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: OTHER: Bicycle Ergometer Training|OTHER: Home-based exercise group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare if the Uptake of Ticagrelor in the Body Differs When Different Tablets Are Administered
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: Ticagrelor granule|DRUG: Ticagrelor pediatric tablets|DRUG: Ticagrelor pediatric tablets suspended in water|DRUG: Ticagrelor immediate release (IR) tablets (Commercial tablet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Colposcopy Versus HPV Testing to Identify Persistent Cervical Precancers
Status: ACTIVE_NOT_RECRUITING
Conditions: High Grade Cervical Intra-epithelial Neoplasia
Interventions: OTHER: high risk HPV DNA testing|OTHER: Active comparator: Routine colposcopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Extension Study of Secukinumab Prefilled Syringes in Subjects With Moderate to Severe Chronic Plaque-type Psoriasis Completing Preceding Psoriasis Phase III Studies With Secukinumab
Status: COMPLETED
Conditions: Moderate to Severe Plaque-type Psoriasis
Interventions: DRUG: Secukinumab (AIN457)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Health-related Quality of Life in Rare Kidney Stone
Status: COMPLETED
Conditions: Primary Hyperoxaluria|Cystinuria|Adenine Phosphoribosyl Transferase Deficiency|Dent Disease
Interventions: OTHER: Health-related Quality of Life in Rare Kidney Stone Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics (PK) Study of Once Daily Darunavir/Ritonavir and Twice and Once Daily Raltegravir in HIV-infected Subjects
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Raltegravir plus Darunavir/ritonavir|DRUG: Raltegravir plus Darunavir/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rosiglitazone and Metformin: Outcomes Trial in Nondiabetic Patients With Stable Coronary Syndromes (Romance) Pilot Study
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: DRUG: AVANDAMET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Quadratus Lumborum and Transverse Abdominis Plane Blocks With Intravenous Analgesic in Gallbladder Surgery
Status: RECRUITING
Conditions: Cholecystectomy
Interventions: PROCEDURE: Quadratus lumborum plane block|PROCEDURE: Transverse abdominis plane block|PROCEDURE: Intravenous analgesia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Liposomal Doxorubicin, Vincristine, & Dexamethasone Plus Arsenic Trioxide in Untreated Symptomatic Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Doxil®|DRUG: Vincristine|DRUG: Dexamethasone|DRUG: Arsenic Trioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BAY 43-9006 Plus Cetuximab to Treat Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Cetuximab|DRUG: BAY 43-9006
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Metabolic Control at Onset of Diabetes on Progression of Type 1 Diabetes
Status: TERMINATED
Conditions: Type 1 Diabetes
Interventions: DEVICE: Closed loop|DEVICE: Home glucose monitoring|DEVICE: Insulin pump|DEVICE: Continuous glucose monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interleukin-2 (IL-2), Interleukin-5 (IL-5) and Interleukin-17 (IL-17) Levels of Patients With Stainless Steel Crowns
Status: RECRUITING
Conditions: Saliva|Dental Crown
Interventions: GENETIC: Salivary Collection|DIAGNOSTIC_TEST: Ph and ion level measurement of saliva
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Shoe Orthotics for Improvement of Biomechanics and Symptoms of Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Lateral wedge|DEVICE: Lateral wedge plus medial arch support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Iphone Technology in Diabetes Treatment
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: BG Star Meter (Conventional) Internet Blood Glucose Reporting|OTHER: iBG Star (iphone) Internet Blood Glucose Method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Efficacy of a Cephalic Mask for Noninvasive Ventilation During Acute Hypercapnic Respiratory Failure
Status: TERMINATED
Conditions: Acute Hypercapnic Respiratory Failure
Interventions: DEVICE: Interface for noninvasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Convection-Enhanced Delivery (CED) of MDNA55 in Adults With Recurrent or Progressive Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma|Grade IV Astrocytoma|Glioblastoma Multiforme|Grade IV Glioma
Interventions: DRUG: MDNA55
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Abdominal Massage on Functional (Primary) Chronic Constipation
Status: COMPLETED
Conditions: Constipation
Interventions: OTHER: Standard bowel management|OTHER: Abdominal massage|OTHER: Placebo Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Guided Imagery in the Perioperative Period in Gynecologic Oncology Patients
Status: COMPLETED
Conditions: Uterine Cervical Neoplasms|Uterine Neoplasms|Ovarian Neoplasms|Urogenital Neoplasms|Fallopian Tube Neoplasms
Interventions: BEHAVIORAL: Guided Imagery With Audio Media
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Exercise Program in Patients With Nontuberculous Mycobacterial Pulmonary Disease
Status: NOT_YET_RECRUITING
Conditions: Nontuberculous Mycobacterial Pulmonary Disease
Interventions: BEHAVIORAL: Exercise Program|BEHAVIORAL: Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effectiveness of Bottle-PEP in Chronic Obstructive Pulmonary Disease
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: BottlePEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical and Radiographic Evaluation of Advanced Platelet Rich Fibrin in the Preservation of Alveolar Ridge Following Atraumatic Tooth Extraction
Status: UNKNOWN
Conditions: Socket Preservation
Interventions: PROCEDURE: Socket preservation with APRF|PROCEDURE: natural healing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sufentanil Infusion vs Sufentanil Bolus
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Sufentanil Infusion|DRUG: Sufentanil Bolus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pain Management Following Total Hip Arthroplasty
Status: COMPLETED
Conditions: Postoperative Pain Intensity|Rescue Pain Requirements
Interventions: DRUG: ropivacaine + ketorolac + adrenaline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Grazoprevir (MK-5172) With Peg-Interferon and Ribavirin in Participants With Chronic Genotype 2 or 3 Hepatitis C (MK-5172-012)
Status: TERMINATED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Grazoprevir|DRUG: Placebo to Grazoprevir|DRUG: Peginterferon alfa-2b (Peg-IFN)|DRUG: Ribavirin (RBV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of a Botanical Drug Product Containing East Indian Sandalwood Oil (EISO) For Treatment of Atopic Dermatitis
Status: WITHDRAWN
Conditions: Atopic Dermatitis
Interventions: DRUG: SAN007 Cream|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tenofovir in HIV/HBV Coinfection
Status: COMPLETED
Conditions: HIV Infection|Hepatitis B Coinfection
Interventions: DRUG: Tenofovir|DRUG: Zidovudine (AZT), lamivudine (LAM), efavirenz (EFV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monoclonal Antibody Therapy, Combination Chemotherapy, and Peripheral Stem Cell Transplant in Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: carmustine|DRUG: cytarabine|DRUG: etoposide|DRUG: melphalan|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: tositumomab and iodine I 131 tositumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)
Status: RECRUITING
Conditions: Advanced Solid Neoplasms
Interventions: DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tandem OnabotulinumtoxinA Galcanezumab Emerging Therapeutic Headache Elimination Research Study
Status: TERMINATED
Conditions: Migraine
Interventions: DRUG: Galcanezumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of High-intensity Laser Therapy in Patients With Carpal Tunnel Syndrome.
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: DEVICE: high-intensity laser therapy|DEVICE: sham high-intensity laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers
Status: RECRUITING
Conditions: Alcohol Consumption|Heavy Drinker|Alcohol Use Disorder (AUD)
Interventions: DRUG: Mavoglurant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment of Oral Lactoferrin as a Safe Antiviral and Immunoregulatory in Treating COVID-19 Disease
Status: UNKNOWN
Conditions: Corona Virus Infection|Middle East Respiratory Syndrome (MERS)|Acute Respiratory Distress Syndrome|Coronavirus Infection|COVID-19|SARS-CoV 2
Interventions: DIETARY_SUPPLEMENT: Lactoferrin (Apolactoferrin)|DRUG: Placebo of excipient(s) will be administered
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 3D -Printed Single Implant Overdentures
Status: COMPLETED
Conditions: Edentulous Mouth
Interventions: OTHER: conventional single implant overdenture|OTHER: 3d printed single implant overdenture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COMPARING TWO PROTOCOLS FOR FINAL OOCYTE MATURATION IN POOR RESPONDERS UNDERGOING GnRH-ANTAGONIST ICSI CYCLES
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: 10000 IU hCG (Choriomon5000 IU; IBSA)|DRUG: Triptorelin 0.2 mg (Decapeptyl 0.1 mg; Ferring)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in First-Line Treatment of Advanced-Stage Classical Hodgkin Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Effectiveness of Tonic, High Frequency and Burst Spinal Cord Stimulation in Chronic Pain Syndromes
Status: UNKNOWN
Conditions: Failed Back Surgery Syndrome|CRPS (Complex Regional Pain Syndromes)
Interventions: DEVICE: Device: Precision Novi™ system Neurostimulation procedures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III, Multicentre, Randomised Study of Fludarabine/Cyclophosphamide Combination With or Without Rituximab in Patients With Untreated Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Control Trial of Sun Protection Interventions for Operating Engineers
Status: COMPLETED
Conditions: Skin Cancer Prevention
Interventions: OTHER: Sunscreen|BEHAVIORAL: Text-Message Reminders|OTHER: Sunscreen and Text Message Reminders|BEHAVIORAL: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Buprenorphine Transdermal System (BTDS) in Subjects With Chronic Nonmalignant Pain
Status: COMPLETED
Conditions: Chronic Non-malignant Pain
Interventions: DRUG: Buprenorphine transdermal patch|DRUG: Placebo to match BTDS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BGS Neonatal Pilot Study
Status: COMPLETED
Conditions: Pain From Heel Sticks
Interventions: DEVICE: BabyGentleStick|DEVICE: Standard Lancing Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Study of Purified Vero Rabies Vaccine and Rabies Human Diploid Cell Vaccine in a Simulated Rabies Post-exposure Regimen
Status: COMPLETED
Conditions: Rabies
Interventions: BIOLOGICAL: Purified Vero Rabies Vaccine (VRVg)|BIOLOGICAL: Imovax® Rabies: inactivated rabies vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Coronally Advanced Flap With Connective Tissue Graft and PRF for Recession Coverage
Status: COMPLETED
Conditions: Gingival Recession
Interventions: PROCEDURE: CAF with Platelet rich fibrin|PROCEDURE: CAF with connective tissue graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: COmplex BifuRcation Lesions: a Comparison Between the AXXESS Device and Culotte Stenting: an Optical Coherence Tomography (OCT) Study
Status: UNKNOWN
Conditions: True Coronary Bifurcation Lesions
Interventions: DEVICE: AXXESS + Biomatrix Biolimus Eluting stent|DEVICE: Culotte technique with Xience V or Xience Prime stents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT