pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: S1702 Isatuximab in Treating Patients With Relapsed or Refractory Primary Amyloidosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Amorphous, Eosinophilic, and Acellular Deposit|Constipation|Diarrhea|Early Satiety|Gastrointestinal Hemorrhage|Hepatomegaly|Lymphadenopathy|Macroglossia|Nausea|Primary Systemic Amyloidosis|Purpura|Recurrent Primary Amyloidosis|Refractory Primary Amyloidosis
Interventions: BIOLOGICAL: Isatuximab|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of HILT in Shoulder Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis of the Shoulder
Interventions: DEVICE: HIRO® 3.0|DEVICE: Sham laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Facilitating Associative Memory Via Deep Transcranial Magnetic Stimulation to the Medial Temporal Lobe
Status: WITHDRAWN
Conditions: Effect of Deep Transcranial Magnetic Stimulation on Memory
Interventions: DEVICE: TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Partially Hydrolyzed, Whey-based Infant Formulas on Growth and Tolerability in Healthy Term Infants
Status: RECRUITING
Conditions: Infant Nutritional Physiological Phenomena|Infant Formula|Infant Health|Infant Development|Growth and Development
Interventions: OTHER: Control Formula|OTHER: Experimental Formula 1|OTHER: Experimental Formula 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of Antiretroviral Therapy to Prevent HBV Intrauterine Infection
Status: UNKNOWN
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Tenofovir1|DRUG: Tenofovir2|DRUG: Tenofovir3|DRUG: Tenofovir4
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Tiotropium 2.5 and 5 mcg Once Daily Delivered Via the Respimat® Inhaler Compared to Placebo and Salmeterol HydroFluoroAlkane (HFA) Metered Dose Inhaler (MDI) (50 mcg Twice Daily) in Patient With Moderate Persistent Asthma I
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Placebo|DRUG: tiotropium Respimat® low dose|DRUG: Placebo|DRUG: Placebo|DRUG: tiotropium Respimat® high dose|DRUG: 50 mcg salmeterol HFA MDI|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Pulmonic Valve REplacement Multi-discIpline EMEA Registry
Status: COMPLETED
Conditions: Pulmonary Regurgitation|Pulmonary Insufficiency|Pulmonary Stenosis
Interventions: DEVICE: Transcatheter Pulmonic Valve Replacement (TPVR) (Edwards SAPIEN™ THV)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Trial to Assess the Safety of Oral SRT2104 and Its Effects on Vascular Dysfunction in Otherwise Healthy Cigarette Smokers and Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo|DRUG: SRT2104
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: COVID-19: A Pilot Study of Adaptive Immunity and Anti-PD1
Status: UNKNOWN
Conditions: COVID-19|SARS-CoV-2|2019-nCoV|Pneumonia, Viral
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Botulinum Toxin Versus Lidocaine in Treating Masticatory Myofascial Face Pain Using Ultrasound and EMG Guided Techniques
Status: TERMINATED
Conditions: Face Pain
Interventions: DRUG: lidocaine|DRUG: chemodenervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of FCN-338 in Patients With Chronic CLL/SLL
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: FCN-338
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Integrase Study
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Stribild® (Tenofovir Disoproxil Fumarate, Elvitegravir, Cobicistat)|DRUG: Isentress® (Raltegravir 400 mg)1 tablet twice a day + Truvada® (FTC & Tenofovir) 1 tablet|DRUG: Tivicay® (Dolutegravir 50 mg) 1 tablet once a day + Truvada® (FTC & Tenofovir)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of SGI-1776, a PIM Kinase Inhibitor, in Subjects With Relapsed/Refractory Leukemias
Status: WITHDRAWN
Conditions: Relapsed/Refractory Leukemias
Interventions: DRUG: SGI-1776
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compassion and Metacognition in Schizotypal Personality
Status: COMPLETED
Conditions: Schizotypal Personality Disorder
Interventions: BEHAVIORAL: Compassion and Metacognition Based Therapy|BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Study of Doxil in a Dose Dense, 14 Day CDOP/Rituximab Regimen for Patients With Diffuse Large B-Cell Non-Hodgkin Lymphoma (NHL)> 60 Years or With Compromised Cardiac Status.
Status: UNKNOWN
Conditions: Diffuse Large B Cell Lymphoma|Lymphoma, Non-Hodgkin
Interventions: DRUG: Doxil|DRUG: Cyclophosphamide|DRUG: Vincristine|DRUG: Prednisone|DRUG: Rituximab|DRUG: Pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: sAfety PerfoRmance chitOsan osteOarthritis ViscosupplEmentation
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Investigational device coded KIO014|DEVICE: Durolane(r) as control device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Postoperative Postures on Persistent Sub-foveal Fluid After Scleral Buckle Surgery
Status: UNKNOWN
Conditions: Retinal Detachment
Interventions: BEHAVIORAL: postoperative postures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesia-Based Sedation During Mechanical Ventilation
Status: UNKNOWN
Conditions: Ventilation, Mechanical|Respiratory Insufficiency|Critical Illness
Interventions: PROCEDURE: Analgesia based sedation in ICU patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Volatile Anesthesia and Total Intravenous Anesthesia on Shedding of the Endothelial Glycocalyx in Patients Undergoing Mastectomy and Breast Reconstruction Using Deep Inferior Epigastric Artery Perforator Free Flap
Status: COMPLETED
Conditions: Deep Inferior Epigastric Artery Perforator Flap Breast Reconstruction
Interventions: DRUG: Propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Platform Trial of Novel Regimens Versus Standard of Care (SoC) in Participants With Non-small Cell Lung Cancer (NSCLC) - Sub-study 1
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Docetaxel|DRUG: Feladilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Efficacy and Safety of PT009 Compared to PT005, PT008, and Symbicort® Turbuhaler® on Lung Function Over 24-Weeks in Subjects With Moderate to Very Severe COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disorder
Interventions: DRUG: BFF MDI 320/9.6 μg|DRUG: BFF MDI 160/9.6 μg|DRUG: FF MDI 9.6 μg|DRUG: BD MDI 320 μg|DRUG: Symbicort® TBH 400/12 μg BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Cannabinoid Agonist on Gastrointestinal and Colonic Motor Functions in Patients With Irritable Bowel Syndrome (IBS)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Dronabinol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Effect of Piezoelectric Alveolar Decortication on Post-Orthodontic Lower Incisors Stability: A Randomized Clinical Trial
Status: COMPLETED
Conditions: Retention
Interventions: PROCEDURE: Piezoelectric Alveolar Decortication, fibrotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Flaxseed in Controlling Blood Pressure of Patients
Status: UNKNOWN
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Flax Oil Capsule|DIETARY_SUPPLEMENT: Placebo Soya Oil Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Hyaluronic Acid Injectable Gel (VYC-25L) for Restoration and Creation of Facial Volume in the Chin and Jaw
Status: COMPLETED
Conditions: Chin Retrusion
Interventions: DEVICE: Hyaluronic Acid Injectable Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of EMDR in Borderline Personality Disorder: a RCT Single-blind Study in a Real-world Care Setting
Status: NOT_YET_RECRUITING
Conditions: Borderline Personality Disorder
Interventions: OTHER: Trauma focused psychotherapy: EMDR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of an Immune-guided Cytomegalovirus Infection Preventive Strategy Compared to a Universal Prophylactic Strategy in Renal Transplant Patients
Status: NOT_YET_RECRUITING
Conditions: Kidney Transplant Infection
Interventions: DRUG: ROVALCYTE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Phase Ib Study of TQB2450 Combined With Anlotinib in Patients With Limited Stage Small Cell Lung Cancer After First-line Radiotherapy and Chemotherapy
Status: RECRUITING
Conditions: Limited Stage Small Cell Lung Cancer|Not Progressed After First-line Chemoradiotherapy
Interventions: DRUG: TQB2450 Injection + Anlotinib Hydrochloride Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Treatment Program "Dr. Fedon Lindbergs Vektcoach" on Body Weight and Composition and Hormonal Profile
Status: COMPLETED
Conditions: Overweight|Obesity|Metabolic Syndrome
Interventions: OTHER: The "Dr. Fedon Lindbergs Vektcoach" Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MK-8150 (MK-8150-002)
Status: COMPLETED
Conditions: Hypertension|Isolated Systolic Hypertension
Interventions: DRUG: MK-8150|DRUG: Placebo for MK-8150
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bacille Calmette-Guerin (BCG) Vaccine for Immune Protection Against Infections
Status: COMPLETED
Conditions: Cystic Fibrosis|Bronchiectasis Adult|Non-Tuberculous Mycobacteria
Interventions: BIOLOGICAL: BCG TICE Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Liraglutide Combined With Short-term CSII on Long-term Glycemic Remission and β Cell Function
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: CSII|DRUG: Liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Microalga Phaeodactylum Tricornutum a Potential Fish Substitute?- Pharmacokinetic Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Pharmacokinetic Parameters
Interventions: DIETARY_SUPPLEMENT: Dried Microalgae biomass
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Do Nanobubbles Improve Joint Hypoxia?
Status: WITHDRAWN
Conditions: Rheumatoid Arthritis|Psoriatic Arthritis
Interventions: DIETARY_SUPPLEMENT: Nanobubble drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of AK104 Plus Axitinib in Advanced/Metastatic Special Pathological Subtypes of Renal Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Renal Cell Carcinoma|First-line Treatment|Non Clear Cell Renal Cell Carcinoma|Sarcomatoid Renal Cell Carcinoma
Interventions: DRUG: AK104|DRUG: Axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: sargramostim|DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: fludarabine phosphate|DRUG: melphalan|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bi Treatment With Hydralazine/Nitrates Versus Placebo in Africans Admitted With Acute Heart Failure
Status: UNKNOWN
Conditions: Acute Heart Failure|Left Ventricular Dysfunction
Interventions: DRUG: Hydralazine|DRUG: Isosorbide Dinitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gingival Recession Treatment Using Two Different Surgical Techniques
Status: COMPLETED
Conditions: Gingival Recession|Root Planing
Interventions: PROCEDURE: xenogeneic collagen matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Disulfiram for Treating Cocaine Dependence in Individuals Maintained on Methadone
Status: COMPLETED
Conditions: Cocaine-Related Disorders|Opioid-Related Disorders
Interventions: DRUG: Disulfiram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Prevalence, Molecular and Genetic Backgrounds of Calcium-Based Stones Among Patients With Renal Calcular Disease in Mansoura Urology and Nephrology Center
Status: COMPLETED
Conditions: Renal Calculi
Interventions: PROCEDURE: percutaneous nephrlolithotomy|GENETIC: VDR gene, CASR gene
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase IIb Study of Intranasal Glutathione in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Reduced Glutathione 100mg|DRUG: Reduced Glutathione 200mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diastology-Guided Management of Decompensated Heart Failure
Status: NOT_YET_RECRUITING
Conditions: Heart Failure|Diastolic Dysfunction
Interventions: DIAGNOSTIC_TEST: Diastology|BEHAVIORAL: Diastology-Guided Diuresis|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Game-Based Foot & Ankle Exercise for Those With Lower Extremity Edema
Status: COMPLETED
Conditions: Lower Extremity Swelling|Lower Extremity Edema|Venous Insufficiency of Leg
Interventions: OTHER: Game-based exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial of High Dose Lenalidomide in Patients With MDS and AML With Trilineage Dysplasia
Status: TERMINATED
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: Lenalidomide 50 mg|DRUG: Lenalidomide 15 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety and Efficacy of Glofitamab or Mosunetuzumab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma and High-Grade Large B-Cell Lymphoma
Status: COMPLETED
Conditions: B-cell Lymphoma
Interventions: DRUG: Glofitamab|DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Mosunetuzumab|DRUG: Obinutuzumab|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Warm Packs, Perineal Massage and Hands Off During Labour in the Perineal Outcomes.
Status: UNKNOWN
Conditions: Perineal Tear
Interventions: PROCEDURE: Warm packs|PROCEDURE: Perineal massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Chlorambucil in Treating Patients With Advanced Chronic Lymphocytic Leukemia
Status: UNKNOWN
Conditions: Leukemia
Interventions: DRUG: chlorambucil|DRUG: cyclophosphamide|DRUG: fludarabine phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Dendritic Cell Vaccination During Lymphoid Reconstruction
Status: COMPLETED
Conditions: Intraocular Melanoma|Melanoma (Skin)
Interventions: BIOLOGICAL: Autologous Dendritic Cells (DC)|DRUG: Fludarabine|BIOLOGICAL: Autologous Lymphocyte Infusion (ALI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BnH-015B Clinical Trial in Moderate Alzheimer's Disease
Status: NOT_YET_RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: BnH-015B 5 mg|DRUG: BnH-015B 10 mg|DRUG: BnH-015B 20 mg|DRUG: BnH-015B 40 mg (Dietary impact)|DRUG: BnH-015B 40 mg|DRUG: BnH-015B 80 mg|DRUG: BnH-015B 160 mg|DRUG: BnH-015B 40 mg (MAD)|DRUG: BnH-015B 80 mg (MAD)|DRUG: BnH-015B 40 mg (Part II)|DRUG: BnH-015B 80 mg (Part II)|DRUG: BnH-015B Placebo (Part II)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-center Phase II Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution in Subjects With Primary Open-angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-angle Glaucoma|Ocular Hypertension
Interventions: DRUG: DE-117 Low Dose ophthalmic solution|DRUG: DE-117 Low/Middle Dose ophthalmic solution|DRUG: DE-117 Middle Dose ophthalmic solution|DRUG: DE-117 Middle/High Dose ophthalmic solution|DRUG: DE-117 High Dose ophthalmic solution|DRUG: latanoprost ophthalmic solution 0.005%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Predictable MR Index for Nonalcoholic Steatohepatitis (NASH)
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis
Interventions: DIAGNOSTIC_TEST: Imaging diagnostic and biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Haloperidol Prophylaxis in Older Emergency Department Patients
Status: COMPLETED
Conditions: Delirium
Interventions: DRUG: Haloperidol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CTSI Pilot: Improving Adherence to Diabetic Diet
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Diet, Healthy|Pre-diabetes
Interventions: BEHAVIORAL: Online - use of online grocery shopping platform|BEHAVIORAL: Default - use of online grocery shopping platform with default shopping carts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparative Effects of Metformin and Insulin on Stereological Studies and Immunohistochemistry of Placenta
Status: COMPLETED
Conditions: Diabetes Mellitus Arising in Pregnancy, Insulin-Requiring|Diabetes Mellitus in Pregnancy
Interventions: DRUG: Metformin|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics of AZD7295 Capsules
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD7295|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Buparlisib and Ofatumumab or Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia
Status: TERMINATED
Conditions: Recurrent Chronic Lymphocytic Leukemia|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Small Lymphocytic Lymphoma
Interventions: DRUG: Buparlisib|DRUG: Ibrutinib|BIOLOGICAL: Ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low -Dose-bevacizumab and Pemetrexed Versus TPC in Metastatic HER2-negative Breast Cancer Patients
Status: UNKNOWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: low-dose-bevacizumab/pemetrexed|DRUG: Treatment of physician's choice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Therapeutic Strategy in ALS Based on Metabolic Status and Associated Metabolic Pathways.
Status: ACTIVE_NOT_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: OTHER: Samples|OTHER: Indirect calorimetry|OTHER: Electrical bioimpedance
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Sleep Apnea Related Inflammation With CRP, ESR and Neutrophil toLymphocyte Ratio
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: OTHER: Evaluation of Sleep Apnea Related Inflammation with CRP, ESR and Neutrophil toLymphocyte Ratio
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The SOS (Stenting Of Saphenous Vein Grafts) Trial
Status: COMPLETED
Conditions: Coronary Artery Bypass|Arteriosclerosis
Interventions: DEVICE: Taxus polymer-based paclitaxel-eluting stent|DEVICE: Express 2 bare metal stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Wheat Breads on Symptoms of IBS, a Pilot Study
Status: COMPLETED
Conditions: Irritable Bowel Syndrome|Wheat Sensitivity
Interventions: OTHER: Sourdough wheat bread|OTHER: Regular yeast baked toast bread|OTHER: Gluten-free diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study Evaluating The Efficacy and Safety of HSK3486 for Sedation or Anesthesia
Status: COMPLETED
Conditions: Sedation or Anesthesia
Interventions: DRUG: HSK3486|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vorinostat and Combination Chemotherapy Before Donor Stem Cell Transplantation for the Treatment of Relapsed Aggressive B-cell or T-cell Non-Hodgkin Lymphoma
Status: WITHDRAWN
Conditions: Recurrent Aggressive Non-Hodgkin Lymphoma|Recurrent B-Cell Non-Hodgkin Lymphoma|Recurrent Burkitt Lymphoma|Recurrent Diffuse Large B-Cell Lymphoma|Recurrent High Grade B-Cell Lymphoma|Recurrent T-Cell Non-Hodgkin Lymphoma|Recurrent Transformed B-Cell Non-Hodgkin Lymphoma
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Busulfan|DRUG: Clofarabine|DRUG: Cyclophosphamide|DRUG: Gemcitabine|DRUG: Mycophenolate Mofetil|BIOLOGICAL: Rituximab|DRUG: Tacrolimus|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vemurafenib Plus Cobimetinib in Advanced or Metastatic Melanoma Patients
Status: TERMINATED
Conditions: Melanoma|Melanoma (Skin)|Melanoma Stage
Interventions: DRUG: Vemurafenib|DRUG: Cobimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cisplatin Based Chemoradiation v.s Radiotherapy for Cervical Cancer and With Clinically Defined Good Prognosis
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A PROspective Faecal MIcrobiota tranSplantation Trial to Improve outcomEs in Patients With Cirrhosis
Status: RECRUITING
Conditions: Liver Cirrhosis
Interventions: DRUG: Encapsulated FMT|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Efficacy and Safety of Ginger Extract Compared With Loratadine for Treatment of Allergic Rhinitis
Status: COMPLETED
Conditions: Rhinitis,Allergic
Interventions: DRUG: Ginger extract|DRUG: Loratadine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Alternative Treatments To Prevent Cognitive Decline in Older Adults With Depression and Anxiety
Status: SUSPENDED
Conditions: Depression Anxiety Disorder
Interventions: OTHER: Mindfulness-Based Cognitive Therapy (MBCT)|OTHER: Health Enhancement Program (HEP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Viral Immunity in Solid Organ Transplant Recipients: Monitoring Of The Response To Hepatitis B Booster Vaccination
Status: NOT_YET_RECRUITING
Conditions: HBV|Kidney Transplantation|Liver Transplantation
Interventions: DRUG: Tacrolimus|DRUG: Belatacept
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination of Nivolumab Plus Relatlimab in Patients With Advanced or Metastatic Soft-tissue Sarcoma: a Proof-of-concept Randomized Phase II Study
Status: RECRUITING
Conditions: Soft Tissue Sarcoma Adult|Advanced Cancer
Interventions: DRUG: Association of Nivolumab + Relatlimab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of SNAGS With and Without Pilates in Lumbar Disc Bulge Patients
Status: RECRUITING
Conditions: Lumbar Disc Herniation|Lumbar Radiculopathy
Interventions: OTHER: SNAGS with Pilates|OTHER: SNAGS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Functional Ingredients in an Acute Metabolic Challenge Context
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: OTHER: Reference breakfast|OTHER: Active Ingredient 1|OTHER: Active Ingredient 2|OTHER: Active Ingredient 3|OTHER: Active Ingredient 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mindfulness and Compassive Acceptance for Chronic Insomnia in Comparison With CBT
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Insomnia|CBT
Interventions: BEHAVIORAL: ACTCOM-I Intervention|BEHAVIORAL: Standard CBT-I Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bilberry-containing Capsules for Dry Eye Mitigation
Status: RECRUITING
Conditions: Dry Eye
Interventions: DIETARY_SUPPLEMENT: Bilberry capsule product|DIETARY_SUPPLEMENT: Placebo(starch)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Early Stereotactic Gamma Knife Radiosurgery to Residual Tumor After Surgery of Newly Diagnosed Glioblastoma
Status: SUSPENDED
Conditions: Glioblastoma
Interventions: RADIATION: gamma knife radiosurgery (15 Gy to 50% isodose)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Left Ventricular Function After Primary Percutaneous Coronary Intervention: Role of Speckle Echocardiography
Status: UNKNOWN
Conditions: Myocardial Infarction|Echocardiography 2D|Left Ventricular Dysfunction
Interventions: DIAGNOSTIC_TEST: Speckle tracking echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rajavtihi Neuronal Adult Stem Cells Project
Status: WITHDRAWN
Conditions: Alzheimer's Disease|Parkinson's Disease|Multiple Sclerosis
Interventions: OTHER: Progenitor Stem Cell Culture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lateral Episiotomy or Not in Vacuum Assisted Delivery in Non-parous Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Pelvic Floor Disorders|Fecal Incontinence|Dystocia|Fetal Hypoxia
Interventions: PROCEDURE: Lateral episiotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Continuous Preperitoneal Infusion of Ropivacaine After Open Liver Resection: Effect on Post-operative Recovery and Morbidity.
Status: TERMINATED
Conditions: Laparotomy|Hepatic Resection
Interventions: DRUG: wound infusion ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multiple Ascending Dose Phase I Study of SB 9200 in Treatment Naïve Adults With Chronic Hepatitis C Infection
Status: COMPLETED
Conditions: Hepatitis C Infection
Interventions: DRUG: SB9200|DRUG: SB9200|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Artesunate Plus Sulfadoxine-pyrimethamine Pharmacokinetics, Efficacy, Gametocytes Carriage and Birth Outcomes in Pregnant Women With Malaria
Status: TERMINATED
Conditions: Malaria
Interventions: DRUG: Artesunate plus sulfadoxine-pyrimethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Tolerability Study of Doripenem Compared With Cefepime in Children Hospitalized With Complicated Urinary Tract Infections
Status: TERMINATED
Conditions: Complicated Urinary Tract Infections or Pyelonephritis
Interventions: DRUG: Doripenem|DRUG: Doripenem placebo|DRUG: Cefepime|DRUG: Cefepime placebo|DRUG: Amoxicillin/clavulanate potassium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for Treatment of Frozen Shoulder Syndrome
Status: UNKNOWN
Conditions: Adhesive Capsulitis
Interventions: OTHER: Electroacupuncture and physical therapy|OTHER: Sham-electroacupuncture and physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mepolizumab Steroid-Sparing Study in Subjects With Severe Refractory Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Mepolizumab|DRUG: Placebo|DRUG: OCS (prednisone/prednisolone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Videomicroscopy for the Prediction of Bleeding in Constitutional Haemorrhagic Diseases
Status: RECRUITING
Conditions: Von Willebrand Diseases|Glanzmann Thrombasthenia
Interventions: DEVICE: Sublingual videomicroscopy|BIOLOGICAL: blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety & Efficacy of Canakinumab (ACZ885) in Patients With Frequent Flares for Whom Nonsterodial Anti-Inflammatory Drug (NSAIDs) and/ or Colchicine Are Contraindicated, Not Tolerated or Ineffective
Status: TERMINATED
Conditions: Gouty Arthritis
Interventions: DRUG: Canakinumab, ACZ885|DRUG: Triamcinolone acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Sleep Duration: Effects on Children's Eating and Activity Behaviors-Renewal
Status: COMPLETED
Conditions: Obesity|Sleep
Interventions: BEHAVIORAL: Optimize Sleep (OS)|BEHAVIORAL: Optimize Sleep-Plus (OS-Plus)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of a Hand-held Digital Cognitive Aid to Anticipated a Simulated Crisis Situation for Resident
Status: ENROLLING_BY_INVITATION
Conditions: Healthy
Interventions: OTHER: Use of a digital cognitive aid in order to anticipate a critical situation|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Analgesic Efficacy and Safety of Hydrocodone Bitartrate/Acetaminophen Immediate-Release Tablets in Participants With Moderate to Severe Pain Following Bunionectomy
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: TV-46763|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Isotonic Versus Hypotonic Fluids in Neonates for Maintenance Fluid Therapy After Surgery
Status: COMPLETED
Conditions: Hyponatremia|Hypernatremia|Postoperative Care in Neonates|Edema
Interventions: DRUG: Isotonic Saline with Dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
Status: NOT_YET_RECRUITING
Conditions: Obstructive Sleep Apnea of Adult|Hypoxia, Brain|Sleep Apnea|Sleep Disorder|Stroke|Blood Pressure|Endothelial Dysfunction|Oxidative Stress
Interventions: DRUG: Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep|DRUG: Drug Lowering CBF and Intermittent Hypoxia Sleep|DRUG: Placebo and Normoxia Sleep|DRUG: Placebo and Intermittent Hypoxia Sleep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Whole Body Magnetic Resonance Angiography in Ischemic Patients
Status: UNKNOWN
Conditions: Atherosclerosis|Intermittent Claudication
Interventions: PROCEDURE: Whole body magnetic resonance angiography (dotarem)|DEVICE: Whole body magnetic resonance angiography (vasovist)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of rSO2 Between Frontal Lesion Area and Normal Area of Brain by NIRSITX Using NIRS in Acute Ischemic Stroke Patients.
Status: NOT_YET_RECRUITING
Conditions: Acute Ischemic Stroke Patients
Interventions: DEVICE: Pulse oximeter, NIRSITX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Comparison of Ultrasound-guided and Palpation-inserted Peripheral Venous Cannula
Status: NOT_YET_RECRUITING
Conditions: Vascular Access Complication|Vascular Access Site Bruising
Interventions: OTHER: Ultrasound-guided vascular access
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: To Compare the Efficacy and Safety of INS068 and Insulin Glargine in Subjects With Type 2 Diabetes Mellitus Not Adequately Controlled With Oral Antidiabetic Drugs
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: INS068 injection|DRUG: Insulin Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Indacaterol and Tiotropium on Inspiratory Capacity
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Indacaterol 150 μg|DRUG: Tiotropium 18 μg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PD-1 Antibody Combined Neoadjuvant Chemotherapy for Ovarian Cancer
Status: RECRUITING
Conditions: Ovarian Cancer|Neoadjuvant Chemotherapy|Anti-PD-1|Neoadjuvant Immunotherapy
Interventions: DRUG: BGB-A317|DRUG: albumin-bound paclitaxel 260mg/m2 , Carboplatin AUC 5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ventral Tegmental Area (VTA) Self-Activation in Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: ADHD
Interventions: OTHER: Real-Time functional Magnetic Resonance Imaging Feedback (RTFF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Targeted Gown and Glove Intervention in Nursing Homes
Status: TERMINATED
Conditions: Staphylococcus Aureus|Carbapenem Resistant Gram Negative Bacteria
Interventions: OTHER: Targeted gown and gloves use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Modulation of Heme Oxygenase 1 by Nizatidine and Lisinopril in Healthy Subjects
Status: COMPLETED
Conditions: Gastroparesis
Interventions: DRUG: Nizatidine|DRUG: Lisinopril|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Autologous Adipose Derived Mesenchymal Stem Cells (AMSC) in Reducing Hemodialysis Arteriovenous Fistula Failure
Status: ACTIVE_NOT_RECRUITING
Conditions: End Stage Renal Disease (ESRD)|Vascular Access Complication
Interventions: BIOLOGICAL: Single Application of Adipose Derived Mesenchymal Stem Cells (AMSC)|DRUG: Placebo|BIOLOGICAL: Two Applications of Adipose Derived Mesenchymal Stem Cells (AMSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial
Status: NOT_YET_RECRUITING
Conditions: Infection, Surgical Site
Interventions: DRUG: Cefazolin|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CoEnzyme Q10 in Statin Myopathy
Status: UNKNOWN
Conditions: Statin Myopathy
Interventions: DRUG: CoEnzyme Q10|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Virtual Reality for Osteoarthritis Knee Pain Pilot
Status: TERMINATED
Conditions: Osteoarthritis of the Knee
Interventions: PROCEDURE: Virtual Reality Training Session|DEVICE: 3D viewer with iPod Touch/iPhone (or similar smartphone)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Safety and Efficacy Study of LJP 394 (Abetimus Sodium) to Treat Lupus Kidney Disease
Status: COMPLETED
Conditions: Immunologic Diseases|Autoimmune Diseases|Systemic Lupus Erythematosus|Lupus Nephritis|Lupus Glomerulonephritis
Interventions: DRUG: Abetimus sodium (LJP 394)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Cytoprotective Agent and Peptic Ulcer in Dual Antiplatelet :RCT
Status: COMPLETED
Conditions: Gastric Ulcer Induced by Anti-platelet Agent|Duodenal Ulcer Induced by Anti-platelet Agent
Interventions: DRUG: Repamipide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Maintenance Belantamab Mafodotin (Blenrep®) After B-cell Maturation Antigen-Directed Chimeric Antigen Receptor T-cell Therapy in Patients With Relapsed and/or Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Refractory Multiple Myeloma|Relapse Multiple Myeloma
Interventions: DRUG: Belantamab mafodotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) and Diagnostic Bronchoscopy
Status: COMPLETED
Conditions: Bronchoscopy
Interventions: DEVICE: THRIVE|DEVICE: Endotracheal tube or Supraglottic airway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Patient Decision Aid for Method of Early Abortion: A Randomized Control Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Abortion in First Trimester|Abortion Early|Decision Aid|Clinical Decision-making|Abortion, Therapeutic
Interventions: OTHER: Decision aid|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A 1/2 Phase Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of ASKB589 in Patients With Locally Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Malignant Solid Tumor
Interventions: DRUG: ASKB589 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Late-Course Accelerated Hyperfractionated IMRT for Locoregionally Advanced Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma
Interventions: RADIATION: Late-course accelerated hyperfractionated IMRT|DRUG: Concomitant cisplatin chemotherapy|RADIATION: Conventionally fractionated IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Piezoelectric Vibrations and Tissue, Cellular and Molecular Mechanisms of Oral Wound Healing After Third Molar Surgery
Status: COMPLETED
Conditions: Tooth, Impacted
Interventions: PROCEDURE: piezo surgery|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of the SNaP Wound Care System in Promoting Healing in Chronic Wounds
Status: WITHDRAWN
Conditions: Lower Extremity Diabetic Leg Wounds|Lower Extremity Venous Leg Wounds|Lower Extremity Mixed Aetiology Leg Wounds
Interventions: DEVICE: SNaP® Wound Care System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Improvement of Transient Elastography Applicability and Diagnostic Accuracy to Identify Significant Fibrosis by Experienced Operators Using the M and XL Probe.
Status: COMPLETED
Conditions: Chronic Liver Diseases (CLD)
Interventions: DEVICE: Trained operator with M probe.|DEVICE: Experienced operator with M probe.|DEVICE: Experienced operator with XL probe.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Robotic Natural Orifice Specimen Extraction Surgery Versus Robotic Transabdominal Specimen Extraction Surgery for Early-Stage Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer|Robotic Surgery|Natural Orifice Specimen Extraction Surgery
Interventions: PROCEDURE: R-NOSES group|PROCEDURE: R-TSES group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p