pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Capecitabine or 5-FU With Pegylated Interferon Alpha-2b in Unresectable/Metastatic Cutaneous Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of Skin|Carcinoma, Squamous Cell
Interventions: DRUG: Pegylated Interferon alpha-2b|DRUG: Capecitabine|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Colchicine After Electrocardioversion for Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation|Cardiac Arrhythmia
Interventions: DRUG: Colchicine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mono vs. Dual Therapy for Pediatric Pulmonary Arterial Hypertension
Status: RECRUITING
Conditions: Pediatric Pulmonary Hypertension
Interventions: DRUG: Mono-Therapy with Sildenafil|DRUG: Duo-Therapy with Sildenafil + Bosentan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of a Fast Diet and Calorie Mimetic Supplements on Epigenetic Aging
Status: UNKNOWN
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: Peak Human Labs calorie mimetic supplement|BEHAVIORAL: Fasting Mimicking Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation (tDCS) As Treatment for Major Depression
Status: COMPLETED
Conditions: Major Depressive Disorder|Unipolar Depression|Depression
Interventions: DEVICE: Transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study Of Nearsightedness; TReatment With Orthokeratology Lenses (CONTROL)
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Orthokeratology lenses|DEVICE: Single-vision spectacles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of SLCO2B1 Genotype and Apple Juice on Pharmacokinetics of Atenolol After Oral Administration in Healthy Male Korean
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Atenolol|DRUG: Atenolol with apple juice 1200 mL|DRUG: Atenolol with apple juice 600 mL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Transplantation in Idiopathic Inflammatory Myopathy Diseases
Status: TERMINATED
Conditions: MYOPATHY
Interventions: BIOLOGICAL: Hematopoietic stem cell transplantation|DRUG: Cyclophosphamide|DRUG: Mesna|DRUG: ATG(rabbit)|DRUG: Methylprednisolone|DRUG: G-CSF|DRUG: Rituxan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Asprosin, Adropin, Irisin Levels in Periodontitis
Status: COMPLETED
Conditions: Periodontal Diseases|Gingivitis|Obesity
Interventions: DIAGNOSTIC_TEST: Clinical periodontal measuremenets|DIAGNOSTIC_TEST: ELISA test from gingival crevicular fluid (GCF)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunoablative Mini Transplant (Hematopoietic Peripheral Blood Stem Cell Transplant [HPBSC])
Status: COMPLETED
Conditions: Tumors|Malignant Melanoma|Hematological Malignancies|Myelogenous Leukemia, Chronic|Leukemia, Lymphoblastic, Acute
Interventions: PROCEDURE: Immunoablative Hematopoietic PBSC Transplant|PROCEDURE: Busulfan pharmacokinetics|RADIATION: Central Nervous System (CNS) prophylaxis radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Safety and Tolerability of MLN8237, In Combination With Erlotinib to Treat Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer Metastatic|Non-small Cell Lung Cancer Recurrent
Interventions: DRUG: MLN8237 and Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Rehabilitation Program in Peripheral Facial Paralysis
Status: TERMINATED
Conditions: Unilateral Peripheral Facial Paralysis
Interventions: OTHER: Neuromuscular Retraining and Virtual therapy|OTHER: Oro-myo-functional classical rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
Status: RECRUITING
Conditions: Bipolar Depression
Interventions: DRUG: Lumateperone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose and Multiple Ascending Dose Study in Healthy Participants and Proof of Mechanism Study in Patients With Ulcerative Colitis
Status: TERMINATED
Conditions: Healthy Volunteers|Ulcerative Colitis
Interventions: DRUG: BMS-986184|DRUG: Placebo matching BMS-986184
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Utilizing a Promotora Model for Rural Adult Hispanics Diagnosed With Metabolic Syndrome: A Clinical Trial
Status: WITHDRAWN
Conditions: Metabolic Syndrome
Interventions: BEHAVIORAL: Promotora plus standard physical screening exam , hemoglobin A1c levels, lipid panels, fasting glucose, height, weight, BMI, Complete Blood Count
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Different Levodopa/Carbidopa/Entacapone Treatment Regimens
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Carbidopa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Copaxone in the Retinal Function in Diabetic Patients After Panphotocoagulation
Status: UNKNOWN
Conditions: Diabetic Retinopathy
Interventions: DRUG: Glatiramer acetate (Copaxone)|DRUG: Mannitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Three Continuing Education Meetings for Community Pharmacists on Weight Management
Status: COMPLETED
Conditions: Continuing Pharmacy Education|Obesity
Interventions: OTHER: Didactic Lecture|OTHER: Interactive Lecture|OTHER: Lecture plus Small Group Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study Assessing Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MGTA-145 in Healthy Volunteers as a Single Agent or in Combination With Plerixafor
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: MGTA-145|BIOLOGICAL: plerixafor|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NM Balance Regulation With ULLS and Loss of Sleep
Status: RECRUITING
Conditions: Muscle Weakness|Quadriceps Muscle Atrophy|Sleep Disturbance
Interventions: BEHAVIORAL: Sleep Restriction|BEHAVIORAL: Sleep Adequate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Investigate the Pharmacokinetics of Midazolam After Repeated Doses of Camizestrant (AZD9833) and to Investigate the Pharmacokinetics of Camizestrant When Administered Alone and in Combination With Carbamazepine in Healthy Post-Menopausal Female Participants
Status: NOT_YET_RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: Midazolam|DRUG: Camizestrant|DRUG: Carbamazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of High Power-Short Duration Versus Standard Power-Long Duration Radiofrequency Ablation for Treatment of Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation|Atrial Fibrillation Paroxysmal|Atrial Fibrillation, Persistent
Interventions: PROCEDURE: Catheter ablation with Standard RF ablation settings|PROCEDURE: Catheter ablation with High Power Short Duration RF ablation settings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Physical Activity in Insurance Medicine: Effects on Patients With Psychiatric Disorders
Status: TERMINATED
Conditions: Depressive Disorder|Somatoform Disorder|Anxiety Disorder|Personality Disorder
Interventions: BEHAVIORAL: Physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Risk Factors for Intraductal Papillary Mucinous Neoplasms Degeneration at the Nancy CHRU (IPMN)
Status: UNKNOWN
Conditions: Study of Risk Factors for IPMNs Degeneration at the Nancy CHRU
Interventions: BEHAVIORAL: Sensitivity and specificity of risk factors for degeneration of IPMNs
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hypofractionated Vs Conventional Fractionated Radiotherapy After Breast Conserving Surgery
Status: RECRUITING
Conditions: Breast Cancer
Interventions: RADIATION: Hypofractionated Radiotherapy|RADIATION: Conventional fractionated Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Rovalpituzumab Tesirine to Study Cardiac Ventricular Repolarization in Subjects With Small Cell Lung Cancer
Status: COMPLETED
Conditions: Small Cell Lung Carcinoma
Interventions: DRUG: Rovalpituzumab Tesirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study With the Sirolimus-Eluting BX Velocity Balloon-Expandable Stent in the Treatment of Diabetic Patients With Native Coronary Artery Lesions
Status: TERMINATED
Conditions: Peripheral Vascular Diseases
Interventions: DEVICE: Sirolimus-Eluting BX Velocity Balloon-Expandable Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Sequential Testosterone and Enzalutamide Prevents Unfavorable Progression
Status: RECRUITING
Conditions: Castration Resistant Metastatic Prostate Cancer
Interventions: DRUG: Testosterone cypionate|DRUG: Enzalutamide|DRUG: Testosterone enanthate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of aerosolizedDornase Alfa Administration in Patients With COVID19 Induced ARDS (COVIDORNASE)
Status: TERMINATED
Conditions: COVID-19|Acute Respiratory Distress Syndrome
Interventions: DRUG: Dornase Alfa Inhalation Solution [Pulmozyme]|PROCEDURE: standard procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Imaging the Patterns of Breast Cancer Early Metastases
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DEVICE: Positron emission tomography/x-ray computed tomography|DEVICE: Magnetic resonance imaging|DEVICE: x-ray computed tomography (CT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Everolimus in Treating Patients With Advanced or Metastatic Colorectal Cancer That Did Not Respond to Previous Therapy
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: everolimus|PROCEDURE: antiangiogenesis therapy|PROCEDURE: biopsy|PROCEDURE: diagnostic procedure|PROCEDURE: gene expression analysis|PROCEDURE: immunohistochemistry staining method|PROCEDURE: laboratory biomarker analysis|PROCEDURE: mutation analysis|PROCEDURE: protein tyrosine kinase inhibitor therapy|PROCEDURE: reverse transcriptase-polymerase chain reaction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STAR and Deferred Stenting Study
Status: RECRUITING
Conditions: Coronary Occlusion|Coronary Stenosis|Coronary Restenosis
Interventions: OTHER: Stent Placement Timing - Early|OTHER: Stent Placement Timing - Late
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Routine Iron Supplementation in Children on Gastrointestinal Iron Losses
Status: COMPLETED
Conditions: Iron Deficiency Anemia|Gastro Intestinal Bleeding|Iron-deficiency
Interventions: DIETARY_SUPPLEMENT: Ferric ammonium citrate and ferrous fumarate syrup (Ranbaxy Ranferon-12 Syrup, Ranbaxy Laboratories, Gurgaon, India)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Back Pain and PostTraumaticStressDisorder. A Randomized Clinical Trial
Status: COMPLETED
Conditions: Low Back Pain|PTSD
Interventions: OTHER: Standard back pain treatment|OTHER: Standard back pain treatment + 10 psychotherapeutic sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cells (MSCs) for Steroid Refractory Acute GVHD (SR-aGVHD)
Status: WITHDRAWN
Conditions: GVHD,Acute
Interventions: BIOLOGICAL: OSSM-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Treatment With the Combination of Drospirenone Plus Ethinyl Estradiol Plus Levomefolate Calcium in Mexican Women Seeking Contraception
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: EE20/DRSP/L-5-MTHF (Beyaz, BAY98-7071)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Research on Underlying Causes of Long-term Use of Nasal Decongestants and the Structured Withdrawal of the Decongestant
Status: RECRUITING
Conditions: Rhinitis Medicamentosa
Interventions: DRUG: Mometasone Furoate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy of Intraocular Lens Optic Capture and In-the-bag Implantation Over 1 Year in Children With Congenital Cataract
Status: UNKNOWN
Conditions: Congenital Cataract|Intraocular Lens Implantation|Optic Capture
Interventions: PROCEDURE: primary or secondary intraocular lens implantation surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Safety and Pharmacology of MEGF0444A in Combination With Bevacizumab With or Without Paclitaxel in Patients With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Solid Cancers
Interventions: DRUG: MEGF0444A|DRUG: bevacizumab|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Innovative Approach to Reduce Lung Cancer Stigma
Status: COMPLETED
Conditions: Lung Cancer Stigma|Lung Cancer|Stigma, Social|Stigmatization|Acceptance Processes
Interventions: BEHAVIORAL: ACT-LCS Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pilot Study of Cabergoline for the Treatment of Cocaine Dependence
Status: COMPLETED
Conditions: Cocaine Dependence|Cocaine Abuse|Cocaine Addiction|Substance Abuse
Interventions: DRUG: Placebo|DRUG: Cabergoline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Klimadynon® in Comparison to Conjugated Oestrogens in Women Suffering From Menopausal Complaints
Status: COMPLETED
Conditions: Menopause
Interventions: DRUG: Low dose of Klimadynon®|DRUG: Medium dose of Klimadynon®|DRUG: High dose of Klimadynon®|DRUG: Oestrofeminal®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Azathioprine Suspension 10 mg/mL (Jayempi) Versus Azathioprine Tablet 50mg (Imurek®)
Status: COMPLETED
Conditions: Therapeutic Equivalency
Interventions: DRUG: Azathioprine 50Mg Tab|DRUG: Azathioprine 10mg/mL oral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: To Demonstrate the Relative Bioequivalence of Lisinopril 1 x 40 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Lisinopril 40 mg Tablet (EON Labs Manufacturing Inc, USA)|DRUG: Lisinopril 40 mg Tablet (Zestril) (Zeneca, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Placement and Stabilization of Dental Implants With Tetranite Stabilization Material in Mandibular and Maxillary Tooth Extraction Sites That Fail to Provide Adequate Primary Stability
Status: COMPLETED
Conditions: Adhesive Dental
Interventions: DEVICE: Tetranite
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Aztreonam for Inhalation in Children With Cystic Fibrosis and New Infection of the Airways by Pseudomonas Aeruginosa Bacteria
Status: TERMINATED
Conditions: Pseudomonas Aeruginosa Respiratory Tract Infection/Colonization|Cystic Fibrosis
Interventions: DRUG: AZLI|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Disitamab Vedotin Combined Therapy for Locally Advanced or Metastatic NSCLC Patients With HER2 Alterations
Status: NOT_YET_RECRUITING
Conditions: Non Small Cell Lung Cancer|ERBB2 Mutation-Related Tumors|RC48|Disitamab Vedotin
Interventions: DRUG: RC48+Tislelizumab+carboplatin|DRUG: RC48+Furmonertinib, 1L|DRUG: RC48+Furmonertinib, 2L+
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project VOICE: Vascular Outcomes Improvement Through Collection of PatiEnt Reported Data
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: BEHAVIORAL: VOICE/Fitbit|OTHER: Daily self-reported exercise adherence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: MOv19-BBz CAR T Cells in aFR Expressing Recurrent High Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Status: TERMINATED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Carcinoma
Interventions: DRUG: MOv19-BBz CAR T cells|DEVICE: Alpha Folate Receptor expression test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxygenation of the Cerebrum and Cooling During Transcatheter Aortic Valve Implantation (TAVI) Procedures - Part II
Status: UNKNOWN
Conditions: Aortic Valve Stenosis|Stroke
Interventions: DEVICE: targeted brain cooling (33°C) by RhinoChill device|DEVICE: Placebo - current clinical practice, no cooling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Performance of a Glass-ionomer Restorative System in Extended-sized Cavities
Status: UNKNOWN
Conditions: Dental Caries Class II
Interventions: OTHER: Equia Forte|OTHER: G-aenial Posterior
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Liver Disease in Urea Cycle Disorders
Status: RECRUITING
Conditions: Urea Cycle Disorder|Ornithine Transcarbamylase Deficiency|Citrullinemia 1|ARGI Deficiency|ASL Deficiency|Argininosuccinic Aciduria|ASS Deficiency|Hyperargininemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nigella Sativa for Selected Outcomes in Chronic Rhinosinusitis
Status: COMPLETED
Conditions: Chronic Rhinosinusitis
Interventions: OTHER: Nigella sativa nasal oil drops|DRUG: standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Nutrient Profiling and Bio-efficacy of Wheat-Barley Composite Flour in Type-2 Diabetes a in Randomized Control Clinical Trial
Status: UNKNOWN
Conditions: Barley/Wheat Composite Flour in Type-2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Wheat-Barley Composite flour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Time Course for Fasting-induced Autophagy in Humans
Status: WITHDRAWN
Conditions: Fasting|Autophagy|Aging Well|Ketosis, Metabolic
Interventions: BEHAVIORAL: Fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prediction of Recovery in Patients With Neck Pain
Status: UNKNOWN
Conditions: Neck Pain|Chronic Neck Pain|Cervical Radiculopathy
Interventions: OTHER: Conventional physical therapy.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography Study of Changes in [11C]AZ14132516 Uptake Following Administration of AZD7798 to Patients With Crohn's Disease.
Status: NOT_YET_RECRUITING
Conditions: Crohn Disease
Interventions: DRUG: AZD7798|DRUG: [11C]AZ14132516
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Midazolam Premedication on the Satisfaction Levels of Patients After Endoscopic Submucosal Dissection
Status: COMPLETED
Conditions: Early Gastric Cancer|Gastric Adenoma
Interventions: DRUG: midazolam 0.02mg/kg|DRUG: No premedication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: CBT for Youth With Autism and Emotional/Behavioral Needs in Community Care Settings
Status: RECRUITING
Conditions: Autism
Interventions: BEHAVIORAL: Behavioral Interventions for Anxiety in Children with Autism (BIACA)|BEHAVIORAL: Treatment-as-Usual Supplemented by Internet-Based Self-Instruction (MEYA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Foley's Catheter Balloon for Induction of Mid Trimester Abortion in Nulliparous Women With or Without Tension Applied
Status: COMPLETED
Conditions: Induction of Abortion
Interventions: OTHER: Tension group|OTHER: No tension group|OTHER: Foley catheter Balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia in Remission|Acute Myeloid Leukemia in Remission|Myelodysplastic Syndromes|Chronic Myeloid Leukemia|Hemophagocytic Lymphohistiocytoses|Primary Immunodeficiency Diseases|Hemoglobinopathies|Severe Aplastic Anemia|Cytopenia|Bone Marrow Failure Syndrome|Severe Chronic Active Epstein-Barr Virus Infection
Interventions: DEVICE: CliniMACS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib in Treating Patients With Lymphoproliferative Disorders
Status: COMPLETED
Conditions: Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma
Interventions: DRUG: bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study for Electroacupuncture for Chemotherapy- Induced Peripheral Neuropathy (CIPN)
Status: COMPLETED
Conditions: Chemotherapy-induced Peripheral Neuropathy
Interventions: DEVICE: Electroacupuncture|DEVICE: NeuroMetrix|DEVICE: Rydel-Seiffer tuning fork
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SvO2 Trigger in Transfusion Strategy After Cardiac Surgery
Status: COMPLETED
Conditions: Undergoing Nonemergent Cardiac Surgery|Central Venous Catheter on the Superior Vena Cava (to Perform ScVO2 Measure)|Anemia (<9g/dL) Requiring Blood Transfusion|Hemodynamic and Respiratory Stability|Bleeding Graded as Insignificant, Mild, Moderate of Universal Definition of Perioperative Bleeding
Interventions: OTHER: Red blood cell tranfusion|OTHER: ScvO2 measure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Interventions to Help Smoking Parents of Inpatients Reduce Exposure (INSPIRE)
Status: COMPLETED
Conditions: Tobacco Use Cessation|Second Hand Tobacco Smoke
Interventions: BEHAVIORAL: Smoking Cessation Intervention Bundle|OTHER: Control Group: Quitline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Parametric Cardiac 18F-flutemetamol PET Imaging in ATTR Cardiomyopathy
Status: RECRUITING
Conditions: Cardiomyopathies, Primary
Interventions: DRUG: (18F)Flutemetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rifaximin for Preventing Progression and Complications in Patients With Decompensated Liver Cirrhosis
Status: RECRUITING
Conditions: Decompensated Cirrhosis
Interventions: DRUG: Low-dose of Rifaximin|DRUG: Conventional dose of Rifaximin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Oxygen Delivery Methods in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease Exacerbation
Interventions: DEVICE: EzPAP®|DEVICE: Non-invasive mechanical ventilation (NIMV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Maintenance Versus Reduction of Immunosuppression for Renal Transplant Patients Hospitalized With COVID-19 Disease
Status: WITHDRAWN
Conditions: COVID|Kidney Transplant; Complications|Immunosuppression
Interventions: OTHER: Maintenance or reduction of immunosuppression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metal Ion Concentration Between Coated and Uncoated TKA
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Coated Total Knee Arthroplasty|DEVICE: Standard Total Knee Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Renal Safety in Patients With Chronic HCV Undergoing Sofosbuvir Containing Antiviral Therapy
Status: UNKNOWN
Conditions: Egyptian Patients, HCV Treatment, Kidney Function
Interventions: DRUG: Sofosbuvir Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Uterine Size and Posture on Intrauterine Contraception in Nulliparous Women
Status: COMPLETED
Conditions: Intrauterine Contraception
Interventions: OTHER: Evaluation of uterine size and posture with ultrasound, IUD insertion, one year follow-up.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mycophenolate Mofetil to Treat Wegener's Granulomatosis and Related Vascular Inflammatory Conditions
Status: COMPLETED
Conditions: Vasculitis|Wegener's Granulomatosis
Interventions: DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of Xueshuantong in Patients With AcutE IschemiC STroke
Status: UNKNOWN
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Xueshuantong lyophilized powder|DRUG: Placebo|OTHER: Guidelines-based standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sexual Absorption of Vaginal Progesterone
Status: COMPLETED
Conditions: Infertility|Pregnancy
Interventions: DRUG: Crinone vaginal progesterone gel|DRUG: Placebo vaginal gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Efficacy, Safety and PK of Intravenous Single Injection LC28-0126 Immediately Before PCI in STEMI Patients
Status: UNKNOWN
Conditions: ST-segment Elevation Myocardial Infarction
Interventions: DRUG: Placebo|DRUG: LC28-0126 Dose A|DRUG: LC28-0126 Dose B|DRUG: LC28-0126 Dose C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Baclofen ER
Status: WITHDRAWN
Conditions: Cocaine Dependence
Interventions: DRUG: Baclofen ER|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasonography Guided Pneumoperitoneum for Laparoscopic Surgery in Morbidly Obese Patients
Status: RECRUITING
Conditions: Pneumoperitoneum|Morbid Obesity|Bariatric Surgery Candidate
Interventions: PROCEDURE: Ultrasonography guided Veress needle insertion for creating pneumoperitoneum|PROCEDURE: Veress needle will be inserted blindly as a closed technique for creating pneumoperitoneum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Social Cognition in Ageing and in Frontotemporal Lobar Degeneration
Status: UNKNOWN
Conditions: Frontotemporal Lobar Degeneration|Aging
Interventions: BEHAVIORAL: Cognitive assessment|OTHER: Brain imaging examination MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Efficacy of Cesamet™ for the Treatment of Pain in Patients With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Cesamet™ (nabilone)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Intra-individual Comparison to Investigate the Efficacy and the Safety of LAS41004 Formulation in Mild to Moderate Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: LAS41004|DRUG: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography (PET) Imaging in Stage III Non-small Cell Lung Cancer (PET START Trial)
Status: COMPLETED
Conditions: Non-Small-Cell Lung Carcinoma
Interventions: PROCEDURE: PET Diagnostic Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Metal-on-conventional-polyethylene vs Ceramic-on-ceramic Articulating Surfaces in Total Hip Arthroplasty
Status: UNKNOWN
Conditions: Arthroplasty Complications
Interventions: DEVICE: Ceramic-on-ceramic uncemented hip arthroplasty|DEVICE: Metal-on-polyethylene uncemented total hip arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Surveillance Trial to Evaluate the Safety of Optison in Clinical Practice.
Status: COMPLETED
Conditions: Echocardiography
Interventions: DRUG: Perflutren Protein-Type A Microspheres Injectable Suspension, United States Pharmacopeia (USP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Prolonged Slow Expiration Technique on Blood Gases Among Pneumatic Neonates
Status: COMPLETED
Conditions: Pneumonia
Interventions: PROCEDURE: Traditional chest physiotherapy|PROCEDURE: Prolonged slow expiration technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Caudal Epidural Injection of Dextrose For Low Back Pain
Status: COMPLETED
Conditions: Back Pain Lower Back Chronic
Interventions: DRUG: Saline|DRUG: Dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicentre Randomised Controlled Trial of HELP (Heat Loss Prevention) in the Delivery Room
Status: TERMINATED
Conditions: Hypothermia in Premature Infants
Interventions: DEVICE: Polyethylene occlusive skin wrap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Food Effect on Sativex Bioavailability
Status: COMPLETED
Conditions: Food Effect
Interventions: DRUG: Sativex|DRUG: Sativex|DRUG: Sativex|DRUG: Sativex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multiparameter Optimized tES for Memory in Aging
Status: NOT_YET_RECRUITING
Conditions: Healthy Aging
Interventions: DEVICE: Transcranial electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Cytoflavin® Used in Elderly Patients for the Prevention of Cognitive Decline After Major Surgery
Status: COMPLETED
Conditions: Cognitive Dysfunction
Interventions: DRUG: Cytoflavin® solution|DRUG: Cytoflavin® enteric-coated tablet|DRUG: Placebo solution|DRUG: Placebo enteric-coated tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Bolus, Intermittent and Continuous Enteral Feeding on Blood Glucose and Feeding Intolerance in ICU Patients With Sepsis
Status: NOT_YET_RECRUITING
Conditions: Enteral Feeding Intolerance
Interventions: OTHER: enteral feeding|PROCEDURE: blood glucose measurements|PROCEDURE: Evaluation of feeding intolerance with gastric residue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Cumulative Irritation Test
Status: COMPLETED
Conditions: Tinea Pedis
Interventions: OTHER: AN2718|DRUG: AN2718|DRUG: AN2718|OTHER: AN2718|DRUG: AN2718|DRUG: AN2718|DRUG: AN2718|DRUG: AN2718|OTHER: Sodium Lauryl Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: EBV CTLs Expressing CD30 Chimeric Receptors For CD 30+ Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma
Interventions: DRUG: autologous CAR.CD30 EBV specific-CTLs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor Cord Blood T-Cell Infusion After Stem Cell Transplant in Treating Patients With Relapsed Hematological Malignancies
Status: TERMINATED
Conditions: Hematopoietic and Lymphoid Cell Neoplasm
Interventions: BIOLOGICAL: Aldesleukin|PROCEDURE: Ex Vivo-Expanded Cord Blood Progenitor Cell Infusion|BIOLOGICAL: Umbilical Cord Blood-Derived Lymphocyte Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Systemic Chemotherapy Combined With Recombinant Human Adenovirus Type 5 and Endostatin Injections for Treatment Malignant Hydrothorax in NSCLC Patients
Status: UNKNOWN
Conditions: Malignant Hydrothorax|Non Small Cell Lung Cancer
Interventions: DRUG: Gemcitabine|DRUG: Vinorelbine|DRUG: Paclitaxel|DRUG: Pemetrexed|DRUG: Oncorine|DRUG: Endostar|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Assessing the Efficacy and Safety of Adalimumab in Active Ulcer(s) of Pyoderma Gangrenosum in Participants in Japan
Status: COMPLETED
Conditions: Pyoderma Gangrenosum
Interventions: DRUG: adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addressing Unfunded Vaccines Through a Co-payment Mechanism in Pharmacies
Status: NOT_YET_RECRUITING
Conditions: Preventable Disease, Vaccine
Interventions: OTHER: Transitional Stepped Co-payment Model - Step 1|OTHER: Transitional Stepped Co-payment Model - Step 2|OTHER: Transitional Stepped Co-payment Model - Step 3|OTHER: Transitional Stepped Co-payment Model - Step 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Safety and Efficacy of ASC40 (Denifanstat) Tablets in the Treatment of Patients With Moderate to Severe Acne Vulgaris
Status: RECRUITING
Conditions: Acne
Interventions: DRUG: ASC40
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Positive Airway Pressure Use in Asthma With Moderate to Severe Obstructive Sleep Apnea Patients
Status: COMPLETED
Conditions: OSA
Interventions: PROCEDURE: CPAP group|PROCEDURE: non CPAP group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of MSC in the Treatment of Fistulas in Patients With Perianal Crohn's Disease
Status: UNKNOWN
Conditions: Crohn's Disease|Fistula
Interventions: PROCEDURE: Routine drainage surgery|BIOLOGICAL: MSC injection 01|BIOLOGICAL: MSC injection 02|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Relative Increase in Bioavailability of (Non-) Nutrients From a Mixed Salad by Adding Fat Containing Dressing
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: OTHER: Test product: Salad with a high dosage fat|OTHER: Control product: Salad with low dosage fat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles
Status: COMPLETED
Conditions: Photodamaged Skin|Wrinkles
Interventions: DRUG: Retinol|DRUG: Tretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Cerebral Correlates of Pedophilia With Neuroimaging Techniques
Status: COMPLETED
Conditions: Pedophilia
Interventions: BEHAVIORAL: Pedophiles patients|BEHAVIORAL: Healthy subjects|DEVICE: PET/MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Critical Time Intervention-Task Shifting: Randomized Controlled Trial
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorder
Interventions: BEHAVIORAL: CTI-TS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Duration and Adverse Events of Non-cuffed Catheter in Patients With Hemodialysis
Status: UNKNOWN
Conditions: Renal Failure Chronic Requiring Hemodialysis|Central Venous Catheterization|Inadequate Hemodialysis Blood Flow|Venous Stenosis|Venous Thrombosis|Infection Due to Central Venous Catheter|Central Venous Catheter Thrombosis
Interventions: DEVICE: GamCath®|PROCEDURE: Arteriovenous fistula creation|DEVICE: GamCath®|PROCEDURE: Arteriovenous fistula creation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Omega-3 LCPUFA Intervention on Learning, Cognition, Behaviour and Visual Processing.
Status: COMPLETED
Conditions: Cognitive Function|Academic Performance|Mental Health
Interventions: DIETARY_SUPPLEMENT: Krill oil capsules|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Comparing the Efficacy and Safety of ABT-874 to Etanercept and Placebo in Subjects With Moderate to Severe Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: BIOLOGICAL: ABT-874|BIOLOGICAL: etanercept|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise in Health and Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Knee-extensor exercise test|OTHER: Exercise test with restricting/releasing blood flow|OTHER: Exercise test with variable oxygen concentration and MRI|OTHER: Exercise test with oral antioxidant or placebo cocktail
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Squeaking in Ceramic-on-Ceramic Total Hip Arthroplasty Using Delta TT Cup
Status: RECRUITING
Conditions: Osteoarthritis, Hip|Osteonecrosis of Femoral Head|Femoral Neck Fractures|Rheumatoid Arthritis of Hip|Posttraumatic Arthropathy
Interventions: PROCEDURE: Total hip arthroplasty with Delta TT cup
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Skin Health and QoL in Pts Receiving Anti-PD1/PDL1/CTLA4 or CDK Inhibitors.
Status: RECRUITING
Conditions: Lung Cancer|Breast Cancer|Kidney Cancer|Bladder Cancer|Gastric Cancer|Skin Cancer|Melanoma|Head Neck Cancer
Interventions: OTHER: EQ-5D-5L questionnaire|OTHER: FACT-G (Functional Assessment of Cancer Therapy - General)|OTHER: FACT-EGFRI-18 (Functional Assessment of Cancer Therapy - Epidermal Growth Factor Inhibitors 18 Item)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Subjective/Psychomotor/ Effects of Combined Alcohol & Nitrous Oxide - 16
Status: COMPLETED
Conditions: Opioid-Related Disorders|Substance-Related Disorders
Interventions: DRUG: 30% Nitrous oxide|OTHER: 0.35 g/Kg ethanol|OTHER: 0.7 g/Kg ethanol|OTHER: 0 g/Kg ethanol
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose:
Clinical trial: Severe Chronic Respiratory Failure and Citrulline
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: ProteoCIT®|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AT9283 in Treating Young Patients With Relapsed or Refractory Acute Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: multikinase inhibitor AT9283|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Pregabalin Reduce the Frequency and Severity of Dry Eye Symptoms After Laser-assisted in Situ Keratomileusis?
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clofarabine and Daunorubicin in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: clofarabine|DRUG: daunorubicin hydrochloride|GENETIC: cytogenetic analysis|GENETIC: protein expression analysis|OTHER: immunologic technique|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT