pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of Different Omeprazole Dosing on Gastric pH in Non-variceal Upper Gastrointestinal Bleeding
Status: COMPLETED
Conditions: Non-variceal Upper Gastrointestinal Bleeding
Interventions: DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bronchial Hyperreactivity in Atopic Dermatitis Patients - a 10 Year Follow-up
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: PROCEDURE: Histamine provocation|PROCEDURE: Skin prick tests|PROCEDURE: Serum IgE blood testing|PROCEDURE: Mantoux-testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Can the Use of Ear Plugs and Eye Masks Help to Improve Sleep Quality After Major Abdominal Surgery?
Status: COMPLETED
Conditions: Sleep|Major Abdominal Surgery|Critical Care
Interventions: OTHER: Ear plugs and eye masks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Lavender Aromatherapy on Patient Anxiety During Mohs Micrographic Surgery
Status: NOT_YET_RECRUITING
Conditions: Skin Cancer|Skin Carcinoma
Interventions: OTHER: Lavender essential oil|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Axitinib and Nivolumab for the Treatment of Mucosal Melanoma
Status: RECRUITING
Conditions: Mucosal Melanoma
Interventions: DRUG: Nivolumab and/or Ipilimumab|RADIATION: Stereotactic Body Radiation Therapy (SBRT)|DRUG: axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combining Flash Glucose Monitoring and Online Peer Support to Improve Outcomes in Hispanics With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Flash Glucose Monitoring with Online Peer Support
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Can Prophylactic Foraminotomy Prevent C5 Palsy
Status: RECRUITING
Conditions: Myelopathy, Compressive|Radiculopathy, Cervical|C5 Palsy
Interventions: PROCEDURE: Bilateral Cervical Keyhole Foraminotomy|PROCEDURE: Cervical Decompression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dehydrated Human Amnion Membrane and Standard of Care Versus Standard of Care Alone in Nonhealing Diabetic Foot Ulcers
Status: NOT_YET_RECRUITING
Conditions: Diabetic Foot|Ulcer Foot|Foot Ulcer|Diabetic Foot Ulcer
Interventions: OTHER: Standard of Care|OTHER: Axolotl DualGraft + SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Escalating and Cumulative-Dose Study of Pharmacokinetics (PK), Pharmacodynamics (PD) and Safety of A006
Status: COMPLETED
Conditions: Asthma|Bronchospasm|Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: A006|DRUG: Placebo DPI|DRUG: Proventil-HFA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autoinflation: Alternative in the Treatment of Otitis Media With Effusion
Status: UNKNOWN
Conditions: Otitis Media With Effusion|Hearing Loss
Interventions: DEVICE: autoinflation device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Enema Device for Children With Spina Bifida
Status: NOT_YET_RECRUITING
Conditions: Spina Bifida|Fecal Incontinence
Interventions: DEVICE: Use of the foley catheter assistive device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Topical Antiadhesion Therapy on Wound Healing and Postoperative Pain After Anal Surgery
Status: UNKNOWN
Conditions: Anal Wound
Interventions: DRUG: 2QR complex|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Several CAMPs in Nonhealing Diabetic Foot and Venous Leg Ulcers
Status: NOT_YET_RECRUITING
Conditions: Diabetic Foot Ulcer|Venous Leg Ulcer
Interventions: OTHER: Amnion-Intermediate-Chorion|OTHER: Amnion-Chorion-Amnion|PROCEDURE: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vasopressin Versus Tranexamic Acid for Control of Blood Loss Related to Abdominal Hysterectomy
Status: NOT_YET_RECRUITING
Conditions: Uterine Surgery
Interventions: DRUG: Vasopressin|DRUG: Tranexamic acid|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: flt3L With or Without Vaccine Therapy in Treating Patients With Metastatic Melanoma or Renal Cell Cancer
Status: COMPLETED
Conditions: Stage IV Melanoma|Stage IV Renal Cell Cancer|Recurrent Renal Cell Cancer|Recurrent Melanoma
Interventions: DRUG: flt3 ligand|DRUG: gp100 antigen|DRUG: MART-1 antigen|DRUG: Montanide ISA-51|DRUG: tyrosinase peptide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Booster Trial to 07-0019 With A/Anhui/05 With and Without MF59
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: MF-59|BIOLOGICAL: A/Anhui/05|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of the Efficiency of Two Different Methods in Managing Early Postoperative Thirst
Status: COMPLETED
Conditions: Patient Satisfaction|Nursing Caries|Post-Op Complication
Interventions: OTHER: Ice Application|OTHER: Wetted Gauze Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Imaging Immune Activation in COVID-19
Status: RECRUITING
Conditions: Covid19|SARS-CoV Infection
Interventions: DRUG: [18F]F-AraG (2'-deoxy-2'-fluoro-9-β-D-arabinofuranosylguanine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Accuracy of 3D Printed Maxillary Complete Dentures
Status: UNKNOWN
Conditions: Accuracy of 3d Printed Dentures
Interventions: PROCEDURE: conventional dentures|PROCEDURE: 3d printed denture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gefitinib and Berberine in the First-line Treatment of Lung Adenocarcinoma With EGFR Mutation
Status: UNKNOWN
Conditions: Lung Adenocarcinoma|EGFR Mutation
Interventions: DRUG: gefitinib|DRUG: Berberine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on Intraluminal Injection of FOLactis
Status: RECRUITING
Conditions: Solid Tumor|Immune Response|Pleural Effusion, Malignant|Peritoneal Effusion
Interventions: OTHER: FOLactis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Intraoperative- Postoperative Effects of Pericapsular Nerve Block and Fascia Iliaca Block in Hip Fracture
Status: COMPLETED
Conditions: Hip Fracture
Interventions: PROCEDURE: Pericapsular nerve group (PENG) block|PROCEDURE: Suprainguinal fascia iliaca plane block
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: DBT Skills Expanded With Contextual Intervention for Long Lasting Symptoms in Borderline Personality Disorder
Status: RECRUITING
Conditions: Borderline Personality Disorders|BPD
Interventions: BEHAVIORAL: Combination DBT, self-compassion and contextual-based skills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Belzutifan (MK-6482) Plus Fulvestrant for ER+/HER2- Metastatic Breast Cancer (MK-6482-029/LITESPARK-029)
Status: NOT_YET_RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Belzutifan|DRUG: Fulvestrant|DRUG: Everolimus|DRUG: Exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of a Cognitive Remediation Program for Bipolar Disorders
Status: RECRUITING
Conditions: Bipolar Disorder
Interventions: OTHER: ECo program|OTHER: CRT program|OTHER: Supportive psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Loncastuximab Tesirine for the Treatment of Relapsed or Refractory B-Cell Malignancies
Status: RECRUITING
Conditions: Post-Transplant Lymphoproliferative Disorder|Recurrent B-Cell Non-Hodgkin Lymphoma|Recurrent Diffuse Large B-Cell Lymphoma|Recurrent Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Neoplastic Post-Transplant Lymphoproliferative Disorder|Refractory B-Cell Non-Hodgkin Lymphoma|Refractory Diffuse Large B-Cell Lymphoma|Refractory Follicular Lymphoma|Refractory Mantle Cell Lymphoma|Refractory Neoplastic Post-Transplant Lymphoproliferative Disorder
Interventions: BIOLOGICAL: Loncastuximab Tesirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT to Investigate if Prostaglandin Analogue Drops Increase the Risk of Cystoid Macular Oedema After Cataract Surgery.
Status: COMPLETED
Conditions: Open Angle Glaucoma and Cataract
Interventions: DRUG: Prostaglandins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blood-sparing During Hip Prosthesis Surgery With Exacyl® in Patients Treated With Rivaroxaban
Status: COMPLETED
Conditions: Blood Loss After a Total Hip Replacement
Interventions: DRUG: Exacyl®|OTHER: Placebo of Exacyl®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Biannual Monitoring With Magnetic Resonance Imaging (MRI), X-ray, or Usual Care on Treatment for Inflammatory Arthritis
Status: UNKNOWN
Conditions: Inflammatory Arthritis
Interventions: OTHER: MRI|OTHER: Radiography|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Milk Ingredients and Resistance Against E-coli-induced GastroEnteritis (MIRAGE)
Status: COMPLETED
Conditions: Bacterial Infection|Diarrhea|Gastroenteritis
Interventions: DIETARY_SUPPLEMENT: Milk protein|DIETARY_SUPPLEMENT: Milk protein rich in phospholipids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Chronic Pelvic Pain in Women - Conservative Group Treatment Compared to Standard Conservative Treatment.
Status: COMPLETED
Conditions: Pelvis Pain Chronic
Interventions: OTHER: Multidisciplinary group treatment|OTHER: Standard physiotherapy treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Dose-Escalation Study to Evaluate the Safety and Pharmacokinetics of Orally Administered DAA-I in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DAA-I|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Anlotinib Versus Docetaxel as the Second-line Treatment in EGFR Wild Type Patients With Advanced NSCLC
Status: UNKNOWN
Conditions: Lung Cancer|Lung Cancer Metastatic
Interventions: DRUG: Anlotinib Hydrochloride|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Mindfulness Intervention on Temperament, Anxiety and Depression: the Mind the Child Study
Status: COMPLETED
Conditions: Child, Only|Temperament|Anxiety|Depression
Interventions: BEHAVIORAL: Mindfulness-based intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Preserved and Preservative-free Latanoprost 0.005% in Primary Open Angle Glaucoma and Ocular Hypertensive Patients, at Guinness Eye Centre, Lagos.
Status: RECRUITING
Conditions: Effect of Drug
Interventions: DRUG: Latanoprost 0.005% Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function
Status: COMPLETED
Conditions: Pulmonary Function; Newborn, Abnormal|Infant Wheeze|In-utero Nicotine|Second Hand Smoke
Interventions: DIETARY_SUPPLEMENT: Vitamin C +prenatal vitamin|DIETARY_SUPPLEMENT: Placebo tablet+prenatal vitamin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: GLP-1 Loading During Elective Percutaneous Coronary Intervention
Status: UNKNOWN
Conditions: Angina Pectoris|Myocardial Infarction|Reperfusion Injury|Coronary Heart Disease
Interventions: DRUG: GLP-1|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of [18F]FAPI-74 PET in Patients With Gastrointestinal Cancers
Status: RECRUITING
Conditions: Gastrointestinal Cancers|Cholangiocarcinoma|Gastric Cancer|Colorectal Cancer|Pancreatic Ductal Adenocarcinoma|Hepatocellular Carcinoma
Interventions: DRUG: [18F]FAPI-74 PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate Cardiovascular Outcomes in Patients With Type 2 Diabetes Treated With ITCA 650
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: ITCA 650|OTHER: ITCA placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: UV Exposure Assessed With Wearable Sensor and Sun Protection
Status: COMPLETED
Conditions: Sunburn, Erythema|Sun Protection
Interventions: BEHAVIORAL: Goal attainment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of PIT565 in Relapsed and/or Refractory B-cell Malignancies
Status: RECRUITING
Conditions: B-cell Non-Hodgkin Lymphoma (B-NHL)|B-cell Acute Lymphoblastic Leukemia (B-ALL)
Interventions: BIOLOGICAL: PIT565
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Switching From One Type of Anti-rejection Drug (Tacrolimus or Cyclosporine) to Another (Sirolimus) Approximately 90-180 Days After Liver Transplantation
Status: WITHDRAWN
Conditions: Side Effects of Calcineurin Inhibitors|Renal Toxicity|Hepatic Fibrosis on Biopsy|Neurotoxicity|Post Transplant Diabetes
Interventions: PROCEDURE: Liver biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fast Track Surgery With Laparoscopic-assisted Gastrectomy for Advanced Gastric Cancer: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: PROCEDURE: fast-track surgery|PROCEDURE: conventional postoperative care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Health Economic Analysis of Islet Cell Transplantation for the Stabilization of the Severe Forms of Type 1 Diabetes
Status: UNKNOWN
Conditions: Type 1 Diabetes
Interventions: PROCEDURE: Islet graft|DRUG: best medical care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Clorazepate Dipotassium 15mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Clorazepate Dipotassium 15mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Study of CXCR5 Modified EGFR Targeted CAR-T Cells for Advanced NSCLC
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: CXCR5 modified EGFR Chimeric Antigen Receptor Autologous T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessement the Reconstruction of Motor Circuits in Nerve Fiber Injuries After the Treatment of Umbilical Cord Mesenchymal Stem Cells With Blood Oxygen Level-dependent Drived Diffusion Tensor Imaging
Status: UNKNOWN
Conditions: Characterize and Evaluate Functional After Transplantation|Determine the Therapeutic Efficiency|Correlate the Imaging Results
Interventions: BIOLOGICAL: stem cell transplantation|PROCEDURE: BOLD-fMRI drived DTI scanning
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Tocilizumab in Lung Transplantation
Status: RECRUITING
Conditions: Lung Transplant
Interventions: DRUG: Tocilizumab|DRUG: Placebo for Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of High Dose-Rate Brachytherapy as Monotherapy in Low and Intermediate Risk Prostate Cancer
Status: UNKNOWN
Conditions: Carcinoma of the Prostate
Interventions: RADIATION: HDR 2 Fraction|RADIATION: HDR 1 Fraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Secondary Intraocular Lens Implantation in Pediatric Patients
Status: UNKNOWN
Conditions: Congenital Cataract
Interventions: PROCEDURE: minimal invasive surgery and secondary IOL implantation|PROCEDURE: traditional cataract surgery and secondary IOL implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Autonomic Modulation in Stroke After Transcranial Direct Current Stimulation and Treadmill Training
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: Transcranial direct current stimulation (tDCS)|DEVICE: training on the running belt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of PB127 Ultrasound Contrast Agent for Diagnosis of Coronary Artery Disease
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: DRUG: PB127 for Injectable Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prophylactic Injection Therapy Reduces Recurrent Bleeding In Forrest Type IIb Duodenal Ulcers
Status: COMPLETED
Conditions: Duodenal Ulcer Bleeding
Interventions: PROCEDURE: prophylactic injection therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Video-Laryngoscope Alone or With Bronchoscope for Predicted Difficult Intubation
Status: COMPLETED
Conditions: Intubation; Difficult
Interventions: DEVICE: King Vision video-laryngoscope with #3 disposable blade and endotracheal tube stylet|DEVICE: fiberoptic bronchoscope aScope III
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Hypoglycaemia in People With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Insulin (Humulin S)|DEVICE: Euglycaemic Hypoglycaemic Insulin clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I/IIa Trial of Folate Binding Protein Vaccine in Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Endometrial Cancer|Fallopian Cancer|Peritoneal Cancer
Interventions: BIOLOGICAL: E39 peptide (100mcg)/GM-CSF vaccine plus E39 booster|OTHER: Non-vaccine clinically matched control group|BIOLOGICAL: E39 peptide (500mcg)/GM-CSF vaccine plus E39 booster|BIOLOGICAL: E39 peptide (1000mcg)/GM-CSF vaccine plus E39 booster|BIOLOGICAL: E39 peptide (100mcg)/GM-CSF vaccine plus J65 booster|BIOLOGICAL: E39 peptide (500mcg)/GM-CSF vaccine plus J65 booster|BIOLOGICAL: E39 peptide (1000mcg)/GM-CSF vaccine plus J65 booster
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SARCOPEDIA - Sarcopenia Diagnostics in Aging Medicine
Status: RECRUITING
Conditions: Sarcopenia|Muscle Weakness|Frailty
Interventions: DIAGNOSTIC_TEST: dual x-ray absorptiometry, body impedance analysis, muscle strength measurements, ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Hartmanns Procedure or Abdominoperineal Excision With Intersphincteric Dissection in Rectal Cancer: a Randomized Study
Status: TERMINATED
Conditions: Rectal Cancer|Sphincter Ani Incontinence|Other Diagnoses, Comorbidities, and Complications
Interventions: PROCEDURE: APE with intersphincteric dissection|PROCEDURE: Hartmann´s procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Seroma Formation After Modified Radical Mastectomy With Flap Fixation Technique in Breast Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast-cancer
Interventions: PROCEDURE: Flap fixation technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Face-to-face and Online Health Education on Women's Cervical Cancer Knowledge, Health Beliefs and Screening
Status: COMPLETED
Conditions: Early Detection of Cancer
Interventions: BEHAVIORAL: face to face health education|BEHAVIORAL: online health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Metabolic and Genetic Impacts of Energy Drinks in Youth
Status: WITHDRAWN
Conditions: Nutrition|Pediatric Obesity|Pediatric|Caffeine|Metabolism Disorder, Glucose|Health Behavior|Glucose Intolerance
Interventions: DIETARY_SUPPLEMENT: Acute energy drink - Placebo|DIETARY_SUPPLEMENT: Acute energy drink - Caffein|DIETARY_SUPPLEMENT: Acute energy drink - Decaf
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial of Gefitinib in Combination With BKM120 in Patients With Advanced Non-Small Cell Lung Cancer, With Enrichment for Patients Whose Tumours Harbour Molecular Alterations of PI3K Pathway and Known to Overexpress EGFR
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer|Solid Tumors
Interventions: DRUG: Gefitinib and BKM120
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conventional CPAP Airsense 10 VS Portable Air-Mini CPAP For Obstructive Sleep Apnea (CASPAM)
Status: RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: CPAP Airsense 10 vs Air-Mini
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular Malformation
Status: COMPLETED
Conditions: Obscure Gastrointestinal Bleeding|Angiodysplasia|Gastric Antral Vascular Ectasia|Thalidomide
Interventions: DRUG: Thalidomide|DRUG: Iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rebif New Formulation (RNF) in Relapsing Forms of Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BIOLOGICAL: Interferon-beta-1a FBS-free/HSA-free
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindful Hearts Study: Mindfulness to Reduce Stress
Status: COMPLETED
Conditions: Cardiovascular Disease|Psychological Stress|Stroke|Coronary Artery Disease
Interventions: BEHAVIORAL: Mindfulness Based Stress Reduction|BEHAVIORAL: Health Education Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Effect of Pharmacokinetics (PK) of Acalabrutinib and Its Active Metabolite (ACP-5862) When Administered Alone and With Moderate CYP3A4 Inhibitors Fluconazole or Isavuconazole in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Acalabrutinib|DRUG: Fluconazole|DRUG: Isavuconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Mediterranean Diet on Remission, Lipid Profile, Weight and Body Composition in Children and Adolescents With Newly Diagnosed Type 1 Diabetes
Status: TERMINATED
Conditions: Type 1 Diabetes
Interventions: OTHER: Interventional arm-Mediterranean diet|OTHER: Control Arm- regular nutritional instructions in accordance with the accepted nutritional guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Activity Scheduling for Older Adults With Dementia
Status: UNKNOWN
Conditions: Older Adults With Mild to Moderate Level of Dementia
Interventions: BEHAVIORAL: Activity Scheduling|BEHAVIORAL: Educational
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location
Status: COMPLETED
Conditions: Persistent Pregnancy of Unknown Location|Ectopic Pregnancy
Interventions: DRUG: Methotrexate|PROCEDURE: Uterine Evacuation|OTHER: Expectant Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BAY1895344 and Copanlisib for the Treatment of Molecularly Selected Patients With Advanced Solid Tumors
Status: WITHDRAWN
Conditions: Locally Advanced Malignant Solid Neoplasm|Metastatic Malignant Neoplasm in the Bone|Metastatic Malignant Solid Neoplasm|Recurrent Malignant Solid Neoplasm
Interventions: DRUG: Copanlisib|DRUG: Elimusertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of HSK21542 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: HSK21542|DRUG: HSK21542|DRUG: HSK21542|DRUG: HSK21542|DRUG: HSK21542|DRUG: HSK21542|DRUG: HSK21542|DRUG: HSK21542|DRUG: HSK21542
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: OPTIMIzing muScle Preservation in paTients wIth Cirrhosis
Status: COMPLETED
Conditions: Obesity|Compensated Cirrhosis|Sarcopenia
Interventions: BEHAVIORAL: Continuous Energy Restriction (CER)|BEHAVIORAL: Alternate Day Modified Fasting (ADMF)|BEHAVIORAL: Group Health Education Sessions|BEHAVIORAL: Late Evening Snack|BEHAVIORAL: Physical activity|BEHAVIORAL: Self-monitoring|BEHAVIORAL: Remotely Supervised Exercise Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Artificial Intelligence Supported Intraoral Scanning.
Status: COMPLETED
Conditions: Impression Technic, Dental
Interventions: DEVICE: AI on algorithm|DEVICE: AI off algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Three-Dimensional Assessment of Maxillary Canine Retraction With and Without Power Arm
Status: ACTIVE_NOT_RECRUITING
Conditions: Power Arm Canine Retraction
Interventions: OTHER: Three-Dimensional Assessment of Maxillary Canine Retraction with Power Arm|OTHER: Three-Dimensional Assessment of Maxillary Canine Retraction without Power Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Remowell 2 and Inspire on Delirium and Cognitive Dysfunction
Status: COMPLETED
Conditions: Cardiac Surgery|Cardiopulmonary Bypass
Interventions: DEVICE: Eurosets REMOWELL 2 oxygenator|DEVICE: LivaNova INSPIRE oxygenator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Factors of Symptoms Generation and Evaluation of Role of Biofeedback in Patients With Different Types of Functional Esophageal Disorders (Functional Heartburn and Functional Chest Pain)
Status: UNKNOWN
Conditions: Chest Pain|Heartburn
Interventions: BEHAVIORAL: Biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MICARDIS® and Valsartan in Patients With Mild-to-Moderate Hypertension Using Ambulatory Blood Pressure Monitoring
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan|DRUG: Valsartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Tolerability and Pharmacokinetics Study of HEC74647PA Capsule in Healthy Adult Subjects
Status: COMPLETED
Conditions: Chronic Hepatitis c
Interventions: DRUG: HEC74647PA Capsule|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Operative Hemodynamic Optimization Using the Plethysmographic Variability Index During Orthopedic Surgery
Status: COMPLETED
Conditions: Hip Arthroplasty|Knee Arthroplasty|General Anesthesia
Interventions: DEVICE: Plethysmographic variability index
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients
Status: COMPLETED
Conditions: Shock, Hemorrhagic|Shock, Traumatic|Acidosis, Lactic
Interventions: DRUG: MP4OX|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sintilimab in Combination With Chidamide in Refractory and Relapsed ENKTCL
Status: COMPLETED
Conditions: Safety and Efficacy
Interventions: DRUG: Sintilimab|DRUG: Chidamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine in Combination With Encorafenib and Cetuximab or Panitumumab in the Treatment of Metastatic BRAF-mutated Colorectal Cancer Refractory
Status: RECRUITING
Conditions: Stage IV Colorectal Cancer Positive for BRAF V600E Mutation|Colorectal Cancer|Colorectal Cancer Stage IV
Interventions: DRUG: Hydroxychloroquine in Combination With Encorafenib and Cetuximab or Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Acupoint Massage Around Eyes on Ocular Biological Indexes
Status: RECRUITING
Conditions: Investigating the Effects of Periocular Acupressure on Ocular Biological Indicators
Interventions: OTHER: acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Nurse-Driven Telephone Intervention in Improving Side Effects in Cancer Patients Undergoing Chemotherapy
Status: COMPLETED
Conditions: Breast Carcinoma|Head and Neck Carcinoma|Sarcoma
Interventions: OTHER: Survey|OTHER: Survey Administration|BEHAVIORAL: Telephone-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of Nilotinib vs. Imatinib in the Treatment of Newly Diagnosed Chinese Ph+ CML-CP Patients
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Nilotinib|DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindfulness Meditation in Treating Insomnia in Multiple Sclerosis
Status: COMPLETED
Conditions: Insomnia Chronic|Multiple Sclerosis
Interventions: BEHAVIORAL: Mindfulness Intervention|BEHAVIORAL: Sleep Hygiene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MGCD0103 in Elderly Patients With Previously Untreated AML/High Risk MDS or Adults With Relapsed/Refractory Disease
Status: TERMINATED
Conditions: Myelogenous Leukemia, Acute|Myelodysplastic Syndromes
Interventions: DRUG: MGCD0103
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alpha-1 Anti-Trypsin (AAT) Treatment in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Alpha 1-Antitrypsin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Performance of the NucleoCapture Device in the Reduction of Circulating cfDNA/NETs in Subjects With Sepsis
Status: NOT_YET_RECRUITING
Conditions: Sepsis|Respiratory Failure
Interventions: DEVICE: NucleoCapture device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Synchronized Trial on Expectant Mothers With Depressive Symptoms by Omega-3 PUFAs (SYNCHRO): Open Trial
Status: COMPLETED
Conditions: Pregnancy|Depression
Interventions: DIETARY_SUPPLEMENT: Omega-3 polyunsaturated fatty acids
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stellate Ganglion Blockade to Reduce Cardiac Anxiety and PTSD Symptoms in Cardiac Arrest Survivors
Status: TERMINATED
Conditions: PTSD|Cardiac Arrest|Anxiety and Fear|Sleep Disturbance|Health Behavior
Interventions: PROCEDURE: stellate ganglion block injection|PROCEDURE: Normal saline injection|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy and Stereotactic Body Radiotherapy (SBRT) for Metastatic Anaplastic Thyroid Cancer
Status: COMPLETED
Conditions: Metastatic Anaplastic Thyroid Cancer
Interventions: DRUG: durvalumab|DRUG: tremelimumab|RADIATION: Stereotactic Body Radiotherapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Quetiapine Fumarate Sustained Release in Major Depression With Comorbid Fibromyalgia Syndrome
Status: COMPLETED
Conditions: Major Depression
Interventions: DRUG: Quetiapine Fumarate Sustained Release|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anesthetic Depth Effects Upon Immune Competent Cells
Status: COMPLETED
Conditions: Immunotoxicity|Anesthesia|Inert Gas Narcosis
Interventions: DRUG: High dose propofol, fentanyl and sevoflurane|DRUG: Low dose propofol, fentanyl and sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PRotein Optimization With eXercise to Improve MUscle Mass and Functional outcomeS
Status: RECRUITING
Conditions: Muscle Loss|Protein|Mobility|Pediatric ALL
Interventions: OTHER: Protein dosage and rehabilitation team delivered exercise prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Trial on Efficacy and Safety for Lobaplatin and Gemcitabine in Combination With Docetaxel in the Second-line Treatments on Advanced Osteosarcoma
Status: UNKNOWN
Conditions: Lobaplatin and Gemcitabine in Combination, Second-line Treatments on Advanced Osteosarcoma
Interventions: DRUG: Docetaxel+lobaplatin|DRUG: Gemcitabine+lobaplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: JanUmet Before Insulin Lantus In Eastern Population Evaluation Program (JUBILEE) In Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Janumet, Lantus|DRUG: metformin, gliclazide, protaphane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous CD133(+) Cells as an Adjuvant to Below the Knee Percutaneous Transluminal Angioplasty
Status: UNKNOWN
Conditions: Peripheral Arterial Disease
Interventions: BIOLOGICAL: G-CSF + CD133(+) cells|BIOLOGICAL: G-CSF|PROCEDURE: percutaneous transluminal angioplasty (PTA)|BIOLOGICAL: Placebo infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Postprandial Hyperinsulinaemic Hypoglycaemia on Driving Performance.
Status: COMPLETED
Conditions: Roux-en-Y Gastric Bypass|Postprandial Hypoglycemia|Driving Impaired
Interventions: DIAGNOSTIC_TEST: Oral glucose tolerance test|DIAGNOSTIC_TEST: Ingestion of placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Endothelial Injury Mechanism in Elderly Patients Undergoing Major Surgery
Status: COMPLETED
Conditions: Endothelial Dysfunction|Blood Brain Barrier Defect|Postoperative Cognitive Dysfunction
Interventions: DRUG: Dexmedetomidine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of White Wine vs. Tea Intake During and an Alcoholic Digestive Following a High Fat, High Calorie Cheese Fondue Meal on Gastric Emptying and Abdominal Symptoms in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DIETARY_SUPPLEMENT: Ingestion of white wine vs. tea during and an alco
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: STAND UP to SARS-CoV-2 (COVID-19): Using Behavioural Economics to Reduce Sedentary Behaviour in At-home Office Workers
Status: COMPLETED
Conditions: Health Behaviour Change
Interventions: BEHAVIORAL: Assigned Strategies: Opt-in|BEHAVIORAL: Assigned Strategies: Active Choice|BEHAVIORAL: Assigned Strategies: Enhanced Active Choice|BEHAVIORAL: Choice of Assignment: Opt-in|BEHAVIORAL: Choice of Assignment: Active Choice|BEHAVIORAL: Choice of Assignment: Enhanced Active Choice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effects of Eccentric-focused Exercise on Posterior Shoulder Tightness in Symptomatic Overhead Athletes
Status: RECRUITING
Conditions: Posterior Shoulder Tightness
Interventions: OTHER: Eccentric-focused exercises|OTHER: Stretching exercises|OTHER: Hot pack|OTHER: Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Multidose Safety and Tolerability Study of Dose Escalation of Liposomal Amikacin for Inhalation (ARIKACE™)
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: ARIKACE™|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neural Mechanisms of Meditation Training in Healthy and Depressed Adolescents: An MRI Connectome Study
Status: COMPLETED
Conditions: Healthy
Interventions: BEHAVIORAL: Training for Awareness, Resilience, and Action (TARA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: REtinal and VIsual Cortical Response in Early PSYchosis
Status: TERMINATED
Conditions: Prodromal Schizophrenia|Psychotic Episode|Prodromal Symptoms|Healthy Controls
Interventions: DEVICE: Retinaute (BioSerenity)|DEVICE: EEG Headset 64 electrodes (BioSemi)|DEVICE: MonPackOne (Metrovision)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Anesthesia, General|Surgical Oncology
Interventions: DRUG: Propofol|DRUG: Volatile Agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of GB-0998 for Treatment of Systemic Sclerosis
Status: COMPLETED
Conditions: Scleroderma, Systemic
Interventions: DRUG: High-dose intravenous immunoglobulin (Venoglobulin-IH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Beneficial Effects of Exercise and Healthy Diets on Muscle and Adipose Tissue
Status: TERMINATED
Conditions: Metabolic Syndrome
Interventions: BEHAVIORAL: Control period|BEHAVIORAL: Diet Group|BEHAVIORAL: Exercise group|BEHAVIORAL: Diet + Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effects of Various Rapid Palatal Expansion Appliances on Dentoskeletal, Dentoalveolar, Nasal and Airway Resistance
Status: COMPLETED
Conditions: Transverse Maxillary Deficiency
Interventions: DEVICE: Tooth Tissue Borne Rapid Palatal Expansion|DEVICE: Tooth Bone Borne Rapid Palatal Expansion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate or Delayed Naturopathic Medicine in Combination With Neo-Adjuvant Chemotherapy for Breast Cancer
Status: TERMINATED
Conditions: Quality of Life
Interventions: BIOLOGICAL: Reishi mushroom extract|DRUG: Coenzyme Q10|DRUG: Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Inflammation, Infection, and Future Cardiovascular Risk
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Disease|Cerebrovascular Accident|Myocardial Infarction|Venous Thromboembolism|Heart Diseases|Infection|Chlamydia Infections|Cytomegalovirus Infections|Helicobacter Infections|Herpesviridae Infections|Inflammation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Antihypertensive Mechanisms of Minocycline in Resistant Hypertension
Status: NOT_YET_RECRUITING
Conditions: Hypertension, Resistant to Conventional Therapy
Interventions: DRUG: Minocycline Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The ADAPT Trial: Adapting Evidence-Based Obesity Interventions in Community Settings
Status: NOT_YET_RECRUITING
Conditions: Childhood Obesity
Interventions: BEHAVIORAL: Competency Based Approaches to Community Health (COACH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GRoningen Early-PD Ambroxol Treatment
Status: RECRUITING
Conditions: Parkinson|Parkinson Disease
Interventions: DRUG: Ambroxol Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT