pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Does Single Dose Imipramine Affect the Opening Pressure of the Urethral and Anal Sphincter?
Status: COMPLETED
Conditions: Urinary Incontinence, Stress|Fecal Incontinence
Interventions: DRUG: Placebo Oral Tablet|DRUG: Imipramine Hydrochloride 25 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1)
Status: RECRUITING
Conditions: HIE|TBI (Traumatic Brain Injury)|TBI|Hemodynamic Instability|Hypoxic-Ischemic Encephalopathy
Interventions: DIAGNOSTIC_TEST: MR Imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multiple Oral Dose Safety, Tolerability And Pharmacokinetic Study Of PF-04287881 In Healthy Adult Subjects
Status: COMPLETED
Conditions: Respiratory Tract Infections
Interventions: DRUG: PF-04287881|DRUG: Placebo|DRUG: PF-04287881|DRUG: Placebo|DRUG: PF-04287881|DRUG: Placebo|DRUG: PF-04287881|DRUG: Placebo|DRUG: PF-04287881|DRUG: Placebo|DRUG: PF-04287881|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Feasibility Study of A VoRo UrologIc ScaffolD (ARID)
Status: RECRUITING
Conditions: Stress Urinary Incontinence|Radical Prostatectomy
Interventions: COMBINATION_PRODUCT: Voro Urologic Scaffold
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treating Refractory Major Depressive Disorder With Repetitive Transcranial Magnetic Stimulation
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate 4 Different Formulations of Meningococcal Serogroups A,C,W-135,Y Conjugate Vaccine When Given as 1 Dose to Healthy Subjects Aged 15-19 Yrs
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: Meningococcal Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Early Life Intervention in Pediatrics Supported by E-health
Status: RECRUITING
Conditions: Adiposity|Childhood Obesity|Adolescent Obesity|Non-communicable Disease|Life Style|Behavior, Eating|Behavior, Health
Interventions: BEHAVIORAL: Life-Style app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Motivational Interviewing on Improving Care for Patients With Type 2 Diabetes in China
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Experimental: Motivational interviewing Placebo Comparator: Traditional lectures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Multiple Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AVE8112 in Patients With Parkinson's Disease
Status: TERMINATED
Conditions: Parkinson's Disease
Interventions: DRUG: AVE8112|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Azadirachta Indica (Homoeopathic Medicine) in Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Azadirachta Indica
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Pharmacokinetics/Safety of Sorafenib + Capecitabine in Advanced Solid Tumors
Status: COMPLETED
Conditions: Refractory Malignancy
Interventions: DRUG: Capecitabine and Sorafenib|DRUG: Capecitabine and Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Year 3 Extension for Efficacy Follow-up in Subjects Vaccinated in Studies Rota-028, 029 or 030 (NCT00197210)
Status: COMPLETED
Conditions: Infections, Rotavirus
Interventions: BIOLOGICAL: Rotarix™|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Impact of Early Versus Delayed Umbilical Cord Clamping in Preeclamptic Pregnant Patients During Cesarean Section
Status: COMPLETED
Conditions: Umbilical Cord Clamping
Interventions: OTHER: Documentation of Maternal blood loss and neonatal outcome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Study of microRNA 107 (miRNA 107) and Beta-amyloid Precursor Protein-cleaving Enzyme 1 (BACE1) Messenger Ribonucleic Acid (mRNA) Gene Expression in Cerebrospinal Fluid and Peripheral Blood of Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer's Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hemodynamic Instability Following Carotid Artery Stenting
Status: COMPLETED
Conditions: Carotid Stenting
Interventions: PROCEDURE: valsalva maneuver|PROCEDURE: valsalva maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Indoor Air Quality Asthma Study: The Effect of Indoor Air Quality and Mitigation of Same on Persistent Asthma
Status: ACTIVE_NOT_RECRUITING
Conditions: Persistent Asthma
Interventions: DEVICE: Indoor Air Quality Mitigation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BRAC Institute of Governance and Development-Hygiene Behavioural Change and Coalition
Status: UNKNOWN
Conditions: Hygiene Practices and Knowledge
Interventions: BEHAVIORAL: Handwashing stations at the public places and no soap|BEHAVIORAL: No activities of the HBCC project and also no soap (Pure Control)|BEHAVIORAL: Soap distributed but no activities of the HBCC project|BEHAVIORAL: HBCC project and Soap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Neuromuscular Blockade for Optimising Surgical Conditions During Spinal Surgery
Status: UNKNOWN
Conditions: Neuromuscular Block|Orthopedic Disorder of Spine|Muscle Weakness
Interventions: DRUG: Rocuronium 0.9 mg/kg|DRUG: Rocuronium 0.6 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Randomized Controlled Trial of Enhanced Cue Exposure Therapy for Negative Emotional Eating
Status: NOT_YET_RECRUITING
Conditions: Disordered Eating Behaviors|Binge Eating
Interventions: BEHAVIORAL: Enhanced Cue Exposure Therapy|BEHAVIORAL: Behavioral Lifestyle Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of H-FIRE and TURP in Treating Benign Prostatic Hyperplasia
Status: RECRUITING
Conditions: Benign Prostatic Hyperplasia
Interventions: PROCEDURE: High freqnence Irreversible electroporation|PROCEDURE: Trans Urethral Resection Prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Dendritic Cells Pulsed With Autologous Apoptotic Tumor Cells Administered to Patients With Brain Tumors
Status: COMPLETED
Conditions: Brain Tumors
Interventions: DRUG: DC/AAT|DRUG: DC/AAT-Flu|DRUG: DC/KLH
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Feeding Readiness and Oral Feeding Success in Preterm Infants
Status: COMPLETED
Conditions: Preterm|Feeding Behavior|Enteral Feeding Intolerance
Interventions: OTHER: Sensorimotor Interventions (Tactile/Kinesthetic Stimulation+Nonnutritive Sucking)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Task Control Circuit Targets for Obsessive Compulsive Behaviors in Children
Status: COMPLETED
Conditions: Obsessive-compulsive Disorders and Symptoms in Children
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|OTHER: Community Referral as appropriate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of VELCADE and Rituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Bortezomib + Rituximab|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Spinal Needles Sizes and Dural Puncture Epidural For Labor Analgesia
Status: COMPLETED
Conditions: Labor Pain|Epidural Analgesia
Interventions: PROCEDURE: 25G Dural Puncture Epidural Block|PROCEDURE: 27G Dural Puncture Epidural Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 1 Study of DHP2302R1 and DHP2302R2 in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: DHP2302R1|DRUG: DHP2302R2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Posterior Capsule Opacification (PCO) With Single Piece Hydrophobic Versus Hydrophillic Intraocular Lens (IOL)
Status: COMPLETED
Conditions: Posterior Capsule Opacification
Interventions: PROCEDURE: Phacoemulsification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety/Tolerability, PK and PD After Intravenous DWJ1521 Administration in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: DWP14012 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Semaglutide for the Treatment of Cognitive Dysfunction in Major Depressive Disorder
Status: ACTIVE_NOT_RECRUITING
Conditions: Major Depressive Disorder
Interventions: BIOLOGICAL: Semaglutide|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study
Status: COMPLETED
Conditions: Glaucoma|Glaucoma Suspect|Diabetic Retinopathy|Ocular Hypertension|Cataract|Branch Retinal Vein Occlusion|Branch Retinal Arterial Occlusion|Central Retinal Vein Occlusion|Central Retinal Artery Occlusion|Epi-retinal Membrane|Macular Degeneration|Drusen|Loss of Vision
Interventions: OTHER: Free Eye Screenings|OTHER: Enhanced Intervention|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Nutrition Trial on the Glycaemic Response to High GI Meals Consumed at Morning vs. Evening-The ChroNu Study
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Glycaemic response to high GI carbohydrates consumed at morning versus evening meals.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Transcatheter Aortic Valve Replacement Versu Surgical Aortix Valve Replacement for Treating Elderly Patients With Severe Aortic Stenosis and Small Aortic Annuli: A Prospective Randomized Study The VIVA Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Degenerative Aortic Valve Disease|Aortic Stenosis|Aortic Regurgitation
Interventions: PROCEDURE: Edwards|PROCEDURE: CoreValve|PROCEDURE: Acurate neo|PROCEDURE: Standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing a Self-persuasion Intervention Promoting Adolescent HPV Vaccination: Feasibility Trial
Status: TERMINATED
Conditions: Human Papillomavirus Vaccines
Interventions: BEHAVIORAL: Project Voice|BEHAVIORAL: HPV Informational Video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma
Status: RECRUITING
Conditions: Barrett Esophagus|Esophageal Adenocarcinoma
Interventions: DEVICE: Sponge Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study Evaluating RO5479599 in Combination With Carboplatin and Paclitaxel in Participants With Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC) of Squamous Histology
Status: TERMINATED
Conditions: Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: RO5479599
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breast Cancer, Aromatase Inhibitor Therapy, and Sexual Functioning: The Effects of Vaginal Testosterone Therapy
Status: COMPLETED
Conditions: Breast Cancer|Vaginal Dryness|Dyspareunia|Sexual Health Quality of Life
Interventions: DRUG: Testosterone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of 40K Pegylated Recombinant Factor IX in Non-Bleeding Patients With Haemophilia B
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia B
Interventions: DRUG: nonacog beta pegol|DRUG: nonacog beta pegol|DRUG: nonacog beta pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine vs. Remifentanil for Sedation During AFI
Status: COMPLETED
Conditions: Intubation, Endotracheal
Interventions: DRUG: Remifentanil|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose:
Clinical trial: Trans Thoracic Ultrasound to Assess Diaphragmatic Function in Stable COPD Versus Bronchial Asthma.
Status: NOT_YET_RECRUITING
Conditions: Diaphragm
Interventions: DEVICE: ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Enteral Nutrition in Acute Generalized Peritonitis
Status: NOT_YET_RECRUITING
Conditions: Enteral and Supplement Feeds Adverse Reaction|Peritonitis; Acute
Interventions: DIETARY_SUPPLEMENT: study group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Experimental Biomarker Study for Pain Thresholds
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: V116517 aqueous suspension|DRUG: Celecoxib capsules|DRUG: Placebo|DRUG: Capsaicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Double Dose of Third-generation EGFR-TKI Plus Intrathecal Pemetrexed Versus Double Dose of Third-generation EGFR-TKI in Patients With LM Progression Following the Treatment of Routine Dose of Third-generation EGFR-TKI
Status: NOT_YET_RECRUITING
Conditions: Leptomeningeal Metastasis
Interventions: DRUG: Double Dose of Third-generation EGFR-TKI|DRUG: Intrathecal Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Marker Changes With Teriparatide/Postmenopausal Osteoporosis
Status: COMPLETED
Conditions: Osteoporosis, Post-Menopausal
Interventions: DRUG: Teriparatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Elixir Medical Clinical Evaluation of the DESolve® Novolimus Eluting Bioresorbable Coronary Scaffold System - The DESolve Nx Trial
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: DESolve Novolimus Eluting Bioresorbable Coronary Scaffold System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Managing Non-acute Subdural Hematoma Using Liquid Materials：a Chinese Randomized Trial of MMA Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Subdural Hematoma, Non-acute
Interventions: DEVICE: Onyx|PROCEDURE: Burr-hole|OTHER: Medical Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Durability of Protection Study of a Recombinant HPV 16/18 Bivalent Vaccine in Female
Status: RECRUITING
Conditions: Cervical Intraepithelial Neoplasia|Cervical Cancer|Vaginal Intraepithelial Neoplasia|Vulvar Intraepithelial Neoplasia|Persistent Infection
Interventions: BIOLOGICAL: Recombinant Human Papillomavirus Bivalent (Types 16, 18) Vaccine (Escherichia coli)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: tDCS and Executive Function Training for Schizophrenia
Status: WITHDRAWN
Conditions: Schizophrenia|Schizophrenia Spectrum Disorder|Schizophrenia and Related Disorders
Interventions: BEHAVIORAL: Transcranial direct current stimulation|BEHAVIORAL: Executive function training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neurocognitive Outcomes After Whole Brain Radiation Therapy for Hematologic Malignancies
Status: RECRUITING
Conditions: Central Nervous System Lymphoma|Hematopoietic and Lymphoid Cell Neoplasm|Leukemia|Lymphoma|Plasma Cell Myeloma|Secondary Central Nervous System Lymphoma
Interventions: PROCEDURE: Magnetic Resonance Imaging|OTHER: Neurocognitive Assessment|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Performance and Safety of MiWEndo-assisted Colonoscopy (MiWEndo II)
Status: RECRUITING
Conditions: Colorectal Cancer|Colorectal Polyp|Colorectal Adenoma|Colorectal Adenomatous Polyp|Colorectal Adenocarcinoma|Colorectal Neoplasms
Interventions: DEVICE: MiWEndo System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pazopanib as Front-Line Therapy in Patients With Non-Resectable or Metastatic Soft Tissue Sarcomas Who Are Not Candidates for Chemotherapy
Status: COMPLETED
Conditions: Sarcoma, Soft Tissue|Soft Tissue Sarcoma
Interventions: DRUG: Pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuraxial Anaesthesia: Does BMI Relate to Ease of Neuraxial Anaesthesia?
Status: UNKNOWN
Conditions: Obesity|Neuraxial Ultrasound|Obstetric Anaesthesia
Interventions: OTHER: Palpation of bony landmarks for neuraxial anaesthesia.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tolterodine Relieves Overactive Bladder Symptoms in Women With Moderate-to-severe Obstructive Sleep Apnea Syndrome
Status: COMPLETED
Conditions: Overactive Bladder|Obstructive Sleep Apnea|Overactive Bladder Syndrome
Interventions: DRUG: Tolterodine Tartrate 4 MG|OTHER: Continuous positive airway pressure therapy (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Multicenter, Open-Label, Randomized Trial of Induction Versus Induction Plus Maintenance Foscarnet ( Foscavir ) Therapy for Gastrointestinal CMV Disease
Status: COMPLETED
Conditions: HIV Infections|Gastrointestinal Diseases
Interventions: DRUG: Foscarnet sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: 3rd Party LMP1/2-Specific Cytotoxic T Lymphocytes for EBV-Associated Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkins Lymphoma|Hodgkins Lymphoma|Lymphoproliferative Disorder
Interventions: DRUG: EBV CTL's|OTHER: Peripheral Blood Donor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study for the Safety and the Pharmacokinetics of DWJ1568 in Healthy Adult Volunteers
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: DWJ1568|DRUG: DWC202215
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effect Between Levofloxacin and Moxifloxacin Among MDR-TB Patients
Status: TERMINATED
Conditions: TB
Interventions: DRUG: levofloxacin, moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Drooling With Type A Botulinum Toxin in Children With Cerebral Palsy
Status: UNKNOWN
Conditions: Cerebral Palsy|Drooling
Interventions: DRUG: botulinum toxin A injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Local Anesthesia Position of Lidocaine Injection on the Success Rate of Radial Artery Puncture Tube
Status: ENROLLING_BY_INVITATION
Conditions: Radial Artery Injury
Interventions: DIAGNOSTIC_TEST: Superior radial artery|DIAGNOSTIC_TEST: Right side of radial artery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Enhancing Parent/Caregiver Engagement in the Pediatric Intensive Care Unit (PICU): A PICU Journal
Status: ENROLLING_BY_INVITATION
Conditions: Critical Illness
Interventions: BEHAVIORAL: PICU Journal
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Laboratory Biomarkers and Pulmonary Interstitial Emphysema in ARDS (PIE-ARDS)
Status: RECRUITING
Conditions: Acute Respiratory Distress Syndrome|Barotrauma
Interventions: DIAGNOSTIC_TEST: Blood and bronchoalveolar fluid collection and analysis|DIAGNOSTIC_TEST: Chest CT scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose Finding Study of Bone Morphogenetic Protein 7 (BMP-7) in Subjects With Osteoarthritis (OA) of the Knee
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: Bone morphogenetic protein 7|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Group-level Intervention to Reduce HIV/STI Risk for Women Who Have Sex With Women in Calgary and Toronto
Status: COMPLETED
Conditions: Safer Sex
Interventions: BEHAVIORAL: Adapted Many Men, Many Voices (3MV) group level intervention|BEHAVIORAL: A group-based HIV/STI prevention intervention for women who have sex with women
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prevention of Infections in Cardiac Surgery (PICS) Prevena Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Surgical Site Infections
Interventions: DEVICE: Prevena|DRUG: Cefazolin|DRUG: Vancomycin|OTHER: standard wound dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Pharmacokinetics/Pharmacodynamics Study of SCH 900518 in Previously Untreated Subjects With Genotype 1 Chronic Hepatitis C (Protocol No. P05104AM2)(COMPLETED)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: BIOLOGICAL: peginterferon alfa 2b|DRUG: ribavirin|DRUG: SCH 900518|DRUG: ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Training in the Virtual Reality Setting With Children Undergoing Radiotherapy for Brain Tumors
Status: RECRUITING
Conditions: Brain Tumor
Interventions: OTHER: Cognitive training via iPad|OTHER: Cognitive training via virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Brown Adipose Tissue as Nutrient Buffer Through Diet Induced Thermogenesis
Status: RECRUITING
Conditions: Brown Adipose Tissue|Metabolic Disease
Interventions: OTHER: Carbohydrate|OTHER: Fat|OTHER: Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Safety, Tolerability, and Pharmacokinetics of Single Doses of PHP-303 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: PHP-303|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of TQB2618 Injection Combined With Penpulimab Injection and Anlotinib Hydrochloride Capsules for First-line Treatment of Advanced Hepatocellular Carcinoma (HCC).
Status: RECRUITING
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DRUG: Penpulimab injection|DRUG: TQB2618 injection|DRUG: Anlotinib Hydrochloride Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Veteran-Centered Colorectal Cancer Screening
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BEHAVIORAL: Decision Aid|BEHAVIORAL: Provider Education|BEHAVIORAL: Performance Measure Modification|BEHAVIORAL: Simple Informational Booklet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Development of a New Immunochemistry Method Using Antibodies of Proteins Related Bile Duct Cancer
Status: COMPLETED
Conditions: Bile Duct Obstruction, Extrahepatic
Interventions: DIAGNOSTIC_TEST: Cytology staining
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Isatuximab as Upfront Therapy for the Treatment of High Risk AL Amyloidosis
Status: ACTIVE_NOT_RECRUITING
Conditions: AL Amyloidosis
Interventions: DRUG: Bortezomib|DRUG: Cyclophosphamide|DRUG: Dexamethasone|BIOLOGICAL: Isatuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Aromatase Inhibitors and GnRH Analogs to Treat Uterine Leiomyoma by Vaginal Hysterectomy
Status: TERMINATED
Conditions: UTERINE LEIOMYOMA
Interventions: PROCEDURE: VAGINAL HYSTERECTOMY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ENOSE in Pulmonary Tuberculosis in Yogyakarta
Status: COMPLETED
Conditions: Pulmonary Tuberculosis Suspected|Other Specified Chronic Obstructive Pulmonary Disease|Pulmonary Tuberculosis TB (+) Histology, (-) Bacteriology
Interventions: OTHER: 5 min exhaled breath sampling with soft nose clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase Ia/Ib, First-in-human (FIH) Study for Safety, Tolerability, Pharmacokinetics (PK), and Clinical Activity Evaluation of ADEL-Y01
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: ADEL-Y01 - healty participants|DRUG: Placebo - Healthy Participants|DRUG: ADEL-Y01 - MCI/AD|DRUG: Placebo - MCI/AD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trauma Informed Guilt Reduction Therapy
Status: UNKNOWN
Conditions: Guilt|Shame|Post-traumatic Stress Disorders
Interventions: BEHAVIORAL: Trauma Informed Guilt Reduction Therapy|BEHAVIORAL: Supportive Care Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Serial SMS Reminders and an Opt-out Mailed FIT Kits to Improve Colorectal Screening Participation: A Single Center RCT
Status: COMPLETED
Conditions: Bowel Cancer|Colon Cancer
Interventions: BEHAVIORAL: Serial text messages and mailed FIT kit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Efficacy of rTMS as an Adjunct to AI Enabled Remedial Intervention in Children With Dyslexia
Status: RECRUITING
Conditions: Dyslexia|Specific Learning Disability|Transcranial Magnetic Stimulation
Interventions: DEVICE: Transcranial magnetic stimulation (Hf rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topiramate, Amitriptyline Monotherapy and Combination Therapy in Migraine Prophylaxis
Status: ENROLLING_BY_INVITATION
Conditions: Migraine
Interventions: DRUG: Topiramate 25Mg Tab|DRUG: Amitriptyline 25 Mg Oral Tablet|DRUG: topiramate 25mg plus amitriptyline 25mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Feasibility of Combining FOLFIRINOX and Stereotactic Radiotherapy for Patients With Irresectable Locally Advanced Pancreatic Cancer.
Status: COMPLETED
Conditions: Pancreatic Neoplasms
Interventions: RADIATION: stereotactic radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RESOLUTE ONYX China Single Arm Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Ischemic Heart Disease|Stenotic Coronary Lesion|Cardiovascular Diseases|Arteriosclerosis|Coronary Artery Disease
Interventions: DEVICE: Resolute Onyx™ Zotarolimus-Eluting Coronary Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3-AP and Gemcitabine in Treating Patients With Advanced Solid Tumors or Lymphoma
Status: COMPLETED
Conditions: Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Primary Central Nervous System Hodgkin Lymphoma|Primary Central Nervous System Non-Hodgkin Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Adult T-cell Leukemia/Lymphoma|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Mycosis Fungoides/Sezary Syndrome|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Adult T-cell Leukemia/Lymphoma|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Mycosis Fungoides/Sezary Syndrome|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific|Waldenström Macroglobulinemia
Interventions: DRUG: gemcitabine hydrochloride|DRUG: triapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 5-HT3 Receptor Antagonist (Ramosetron) vs Loperamide for the Treatment of Low Anterior Resection Syndrome(RALARS)
Status: RECRUITING
Conditions: LARS - Low Anterior Resection Syndrome
Interventions: DRUG: Ramosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemox as First and Second Line Therapy in Unknown Primary Cancer
Status: COMPLETED
Conditions: Unknown Primary Neoplasms
Interventions: DRUG: Gemcitabine (Gemox)|DRUG: Oxaliplatin|BEHAVIORAL: Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of the Study Medicine (PF-07081532) in People With Diabetes and Kidney Dysfunction
Status: TERMINATED
Conditions: Type 2 Diabetes|Renal Impairment
Interventions: DRUG: PF-07081532
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cooperative Re-Engagement Controlled Trial (CoRECT)
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: OTHER: Anti-Retroviral Treatment and Access to Services (ARTAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: EMDR in the Treatment of Specific Phobia.
Status: WITHDRAWN
Conditions: Specific Phobia
Interventions: OTHER: EMDR (Eye Movement Desensitization and Reprocessing)|OTHER: Exposure therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy 2 Part Study of Identification of Keloid Biomarkers and Effect of QAX576 on Keloid Recurrence
Status: TERMINATED
Conditions: Keloids
Interventions: DRUG: QAX576|DRUG: QAX576 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Four Arms, Multicenter Study of Tailored Regimens With Peginterferon Plus Ribavirin for Genotype 2 Chronic Hepatitis C
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: pegylated interferon alpha 2a and plus ribavirin|DRUG: Pegylated interferon alfa-2a and ribavirin|DRUG: pegylated interferon alpha 2a and ribavirin|DRUG: pegylated interferon alpha 2a and ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient's TeleMonitoring With Amyotrophic Lateral Sclerosis Treated by Non Invasive Ventilation at Home.
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis|Noninvasive Ventilation
Interventions: OTHER: teleconsultation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Immunogenicity and Safety of Three Consecutive Lots of a New Inactivated Enterovirus Type 71 (EV71) Vaccine
Status: COMPLETED
Conditions: Hand, Foot and Mouth Disease
Interventions: BIOLOGICAL: three consecutive lots of EV71 vaccine|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: ch14.18 Pharmacokinetic Study in High-risk Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: BIOLOGICAL: ch14.18 -NCI|BIOLOGICAL: ch14.18-UTC|BIOLOGICAL: Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)|BIOLOGICAL: Aldesleukin (IL-2)|DRUG: Isotretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Artemisinin Combination Therapies for the Treatment of Uncomplicated P. Vivax in Pregnancy in Brazil (PAACT-PV)
Status: TERMINATED
Conditions: Plasmodium Vivax Malaria
Interventions: DRUG: Mefloquine- Artesunate|DRUG: Artemether-Lumefantrine|DRUG: Chloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rigid Versus Flexible Cystoscopy in Women
Status: COMPLETED
Conditions: Hematuria|Urination Disorders|Voiding Dysfunction|Recurrent Urinary Tract Infection
Interventions: DEVICE: Flexible Cystoscopy|DEVICE: Rigid Cystoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Absorption, Metabolism, Excretion, and Mass Balance Study of [14C]-VVZ-149 in Healthy Adult Male Subjects
Status: COMPLETED
Conditions: Healthy Adult Male
Interventions: DRUG: [14C]-VVZ-149
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Uptake of the Childhood Live Attenuated Influenza Vaccine (LAIV) and Influenza-related Healthcare Resource Use in England During the 2012 to 2022 Flu Seasons; a Retrospective, Observational Study in the CPRD and HES Databases
Status: COMPLETED
Conditions: Influenza
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Optimizing Pregnancy and Treatment Interventions for Moms 2.0
Status: COMPLETED
Conditions: Pregnancy, High Risk|Opioid-Related Disorders|Pregnancy Related
Interventions: BEHAVIORAL: Patient Navigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Does the Ingestion of Mycoprotein Elicit an Optimal Anabolic Response in Resting and Exercised Skeletal Muscle?
Status: UNKNOWN
Conditions: Healthy
Interventions: OTHER: Mycoprotein beverage|OTHER: Milk protein beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Renin-Angiotensin Aldosterone System and Fibrinolysis Interaction in Humans-Specific Aim 3
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Control (bradykinin)|DRUG: L-NMMA + bradykinin|DRUG: Isosorbide + L-NMMA + bradykinin|DRUG: Sildenafil + L-NMMA + bradykinin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cisplatin Plus Irinotecan in Treating Patients With Ovarian, Fallopian Tube, or Peritoneal Cancer
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: cisplatin|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Human AntiCD19 Chimeric Antigen Receptor T Cells for Relapsed or Refractory Lymphoid Malignancies
Status: RECRUITING
Conditions: Non Hodgkin Lymphoma|Acute Lymphoblastic Leukemia|Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: Fully human anti CD19 CAR-T Cell Dose|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization of iTBS for Depression
Status: RECRUITING
Conditions: Neuromodulation
Interventions: DEVICE: Monophasic iTBS|DEVICE: Biphasic iTBS|DEVICE: Monophasic-Long iTBS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Empagliflozin on Arterial Wall Characteristics
Status: UNKNOWN
Conditions: Vascular Stiffness|Hypoglycemic Agents|Diabetes Complications|Diabetes Mellitus, Type 1
Interventions: DRUG: Empagliflozin 25mg|DRUG: Metformin|DRUG: Empagliflozin/Metformin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intervention Study to Compare the Natriuretic Effects of Enalapril on Low and High Salt Diet
Status: COMPLETED
Conditions: Salt-sensitive Hypertension
Interventions: DRUG: Fenoldopam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: MINIject Implantation Combined With Cataract Surgery in Patients With POAG and Cataract
Status: ENROLLING_BY_INVITATION
Conditions: Primary Open-angle Glaucoma|Cataract
Interventions: DEVICE: Phacoemulsification combined with minimally invasive glaucoma surgery (MIGS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comperasion the Postoperative Effect of Low Laser Therapy and Platelet Rich Fibrin on Mandibular Third Molar Surgery.
Status: COMPLETED
Conditions: Impacted Third Molar Tooth
Interventions: DIAGNOSTIC_TEST: Diagnoses|PROCEDURE: traditional osteotomies|BIOLOGICAL: platelet rich fibrin|DRUG: Antibiotics, Penicillin|DEVICE: low laser therapy, bicure laser|DRUG: Analgesic
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vegan Diet, Amla Fruits and Uric Acid
Status: RECRUITING
Conditions: Hyperuricemia|Diet, Healthy|Cardiometabolic Syndrome
Interventions: OTHER: Healthy vegan diet|OTHER: My Plate - Low Purine|OTHER: Amla fruits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Support for Adolescents Living With HIV in South Africa
Status: RECRUITING
Conditions: Human Immunodeficiency Virus|HIV
Interventions: BEHAVIORAL: In-person adolescent-friendly service (iPAS) intervention|BEHAVIORAL: mHealth (InTSHA) intervention|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Development of a Cabozantinib (Cabometyx) Symptom Management Application for Use in Patients With Renal Cancer
Status: TERMINATED
Conditions: Metastatic Renal Cell Carcinoma Treated With Cabozantinib
Interventions: DEVICE: Usability of an electronic symptom management application
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Radiolabel ADME (Absorption, Distribution, Metabolism, and Excretion) Study Of [14C] PF-00868554 In Healthy Adult Male Subjects
Status: COMPLETED
Conditions: HCV
Interventions: DRUG: [14C]-PF-00868554
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Survey Study and Records Review of Treatment Outcomes in Freeman-Sheldon Syndrome
Status: UNKNOWN
Conditions: Freeman-Burian Syndrome|Freeman-Sheldon Syndrome|Whistling Face Syndrome|Sheldon-Hall Syndrome|Freeman-Sheldon Syndrome Variant|Arthrogryposis Distal Type 1|Arthrogryposis Distal Type 3|Gordon Syndrome
Interventions: OTHER: Guided Health History for Freeman-Burian Syndrome Questionnaire|OTHER: Freeman-Burian syndrome Semi-Structured Quality of Life Interview|OTHER: Medical Records Review|OTHER: PTSD Checklist for DSM-5|OTHER: Modified Flanagan Quality of Life Scale|OTHER: Center for Epidemiologic Studies Depression Scale|OTHER: Review of Systems|OTHER: FACE-Q | Craniofacial - Appearance of the Face|OTHER: FACE-Q | Craniofacial - Appearance Distress|OTHER: FACE-Q | Craniofacial - Facial Function
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dietary Polyphenols and Insulin Sensitivity in Overweight and Obese Humans
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: EGCG+RSV-supplementation|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: VisiOn Restoration With FluidVisION Accommodating Intraocular Lens (AIOL)
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: FluidVision AIOL|DEVICE: AcrySof IQ monofocal IOL|PROCEDURE: Cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY