pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety Evaluation of Pegamotecan (PEG-camptothecin) in Advanced or Metastatic Soft Tissue Sarcoma
Status: SUSPENDED
Conditions: Sarcoma, Soft Tissue
Interventions: DRUG: Pegamotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of Hepatitis A Vaccine Given at the Same Time of Measles, Mumps, Rubella Combined Vaccine
Status: COMPLETED
Conditions: Measles|Mumps|Rubella|Hepatitis A
Interventions: BIOLOGICAL: Inactivated Hep A vaccine; Attenuated Measles Mumps Rubella|BIOLOGICAL: Attenuated Measles Mumps Rubella; Inactivated Hep A vaccine|BIOLOGICAL: Inactivated Hep A vaccine; Attenuated Measles Mumps Rubella
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Recurrent Childhood Ependymoma|Recurrent Ewing Sarcoma|Recurrent Glioma|Recurrent Hepatoblastoma|Recurrent Kidney Wilms Tumor|Recurrent Langerhans Cell Histiocytosis|Recurrent Malignant Germ Cell Tumor|Recurrent Malignant Glioma|Recurrent Medulloblastoma|Recurrent Neuroblastoma|Recurrent Non-Hodgkin Lymphoma|Recurrent Osteosarcoma|Recurrent Peripheral Primitive Neuroectodermal Tumor|Recurrent Rhabdoid Tumor|Recurrent Rhabdomyosarcoma|Recurrent Soft Tissue Sarcoma|Refractory Ependymoma|Refractory Ewing Sarcoma|Refractory Glioma|Refractory Hepatoblastoma|Refractory Langerhans Cell Histiocytosis|Refractory Malignant Germ Cell Tumor|Refractory Malignant Glioma|Refractory Medulloblastoma|Refractory Neuroblastoma|Refractory Non-Hodgkin Lymphoma|Refractory Osteosarcoma|Refractory Peripheral Primitive Neuroectodermal Tumor|Refractory Rhabdoid Tumor|Refractory Rhabdomyosarcoma|Refractory Soft Tissue Sarcoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Palbociclib|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Use of Magnetic Resonance Perfusion Imaging to Qualitatively Assess Adequate Distal Perfusion After Endovascular Revascularization in Critical Limb Ischemia
Status: COMPLETED
Conditions: Lower Limb|Ischemia|Perfusion
Interventions: PROCEDURE: Magnetic Resonance Perfusion Imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SENOC-I Det Sunda Huset II - Sensitization of Occupants of Water Damaged Buildings.
Status: COMPLETED
Conditions: Upper Airway, Irritation Inflammation, Discomfort
Interventions: BEHAVIORAL: House dust
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Study of Biomarkers and the Relaxation Response Using Guided Imagery in Women With IC
Status: COMPLETED
Conditions: Interstitial Cystitis|Pelvic Pain
Interventions: BEHAVIORAL: Relaxation Response using Guided Imagery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Interaction of Other Drugs With TAK-279 in Healthy Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Midazolam|DRUG: Repaglinide|DRUG: TAK-279
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Modifications to Radical Prostatectomy: Feasibility Study
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: radical prostatectomy with urethral irrigation but no fascial suturing, QOL forms|PROCEDURE: radical prostatectomy with fascial suturing but no urethral irrigation, QOL forms|PROCEDURE: radical prostatectomy with both urethral irrigation and fascial suturing, QOL forms|PROCEDURE: radical prostatectomy with neither urethral irrigation nor fascial suturing, QOL forms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microcurrent Stimulation Therapy for Nonexudative Age-related Macular Degeneration (i-SIGHT)
Status: ACTIVE_NOT_RECRUITING
Conditions: Age-Related Macular Degeneration|Dry Age-related Macular Degeneration|Nonexudative Age-related Macular Degeneration
Interventions: DEVICE: i-Lumen(TM) AMD|DEVICE: i-Lumen(TM) AMD Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Translation of Basic Research in Cognitive Science to HIV Risk
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: BEHAVIORAL: Health Education|BEHAVIORAL: Action Plan|BEHAVIORAL: Memory Practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Usefulness of NESA Microcurrents in the Treatment of Children With Autism Spectrum Disorders
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DEVICE: Non-invasive Neuromodulation|DEVICE: Placebo Non-invasive Neuromodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of AK104 With Chemotherapy as First-line Treatment in Patients With Advanced Pancreatic Cancer
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: AK104|DRUG: AK104|DRUG: Gemcitabine|DRUG: Nab-Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lentivirus Transduced Acute Myeloid Leukaemia Blasts Expressing B7.1 (CD80) and IL-2
Status: UNKNOWN
Conditions: Leukemia, Myeloid, Acute
Interventions: BIOLOGICAL: RFUSIN2-AML1|BIOLOGICAL: Donor leukocyte infusion (DLI)|BIOLOGICAL: RFUSIN2-AML1 and donor leukocyte infusion|BIOLOGICAL: RFUSIN2-AML1 and donor leukocyte infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Salicylic Acid Versus Cryotherapy for the Treatment of HPV1-induced Plantar Warts
Status: NOT_YET_RECRUITING
Conditions: Warts
Interventions: OTHER: salicylic acid|OTHER: cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Unified Protocol for Treatment of Emotional Disorders in Brief Groups in Primary Care Services in Spain
Status: RECRUITING
Conditions: Emotional Disorder|Anxiety Disorders|Depressive Disorder
Interventions: BEHAVIORAL: 5-session UP condition|BEHAVIORAL: 8-session UP condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Bioequivalence of Fixed Dose Combination of HR20033 Relative to Co-administration of the Individual Components in Healthy Chinese Subjects
Status: UNKNOWN
Conditions: Type II Diabetes
Interventions: DRUG: T1: FDC 5/500 mg; R1+R: SHR3824 5 mg + Metformin 500 mg XR|DRUG: T1: FDC 5/500 mg; R1+R: SHR3824 5 mg + Metformin 500 mg XR|DRUG: T2: FDC 5/1000 mg; R2+R: SHR3824 5 mg + two Metformin 500 mg XR|DRUG: T2: FDC 5/1000 mg; R2+R: SHR3824 5 mg + two Metformin 500 mg XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sems Placement With and Without Biliary Sphincterectomy in Patients With Malignant Biliary Obstruction
Status: RECRUITING
Conditions: Malignant Bile Duct Obstruction
Interventions: PROCEDURE: ES before fully covered SEMS placement|PROCEDURE: no ES before fully covered SEMS placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Staples Versus Prolene Suture for Skin Closure at Cesarean Delivery
Status: COMPLETED
Conditions: Pregnancy|Cesarean Section
Interventions: PROCEDURE: Staples|PROCEDURE: Prolene non-absorbable sutures|PROCEDURE: Absorbable Sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cell-derived Pleiotropic Factor in the Treatment of Donor Sites
Status: UNKNOWN
Conditions: Evaluate the Safety and Effectiveness of Mesenchymal Stem Cell Conditioned Medium-derived Pleiotropic Factor in Treating Donor Sites
Interventions: BIOLOGICAL: mesenchymal stem cell conditioned medium-derived pleiotropic factor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TAME: A Pilot Study of Weekly Paclitaxel, Bevacizumab, and Tumor Associated Macrophage Targeted Therapy (Zoledronic Acid) in Women With Recurrent, Platinum-resistant, Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Epithelial Ovarian|Fallopian Tube|Primary Peritoneal Cancer
Interventions: DRUG: Paclitaxel/Bev (control)|DRUG: Paclitaxel/Bev + ZA (experimental)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Levomilnacipran ER|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate Efficacy, Safety, and Pharmacokinetics of Delgocitinib Cream in Chinese Adults and Adolescents With Moderate to Severe Chronic Hand Eczema
Status: RECRUITING
Conditions: Chronic Hand Eczema
Interventions: DRUG: Delgocitinib|OTHER: Vehicle cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SIR-Spheres® Microspheres Versus Transarterial Chemoembolisation in Patients With Unresectable Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DEVICE: Radioembolisation (SIR-Spheres® microspheres)|DRUG: Transarterial Chemoembolisation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CDI-31244 in Combination With Sofosbuvir (SOF) and Velpatasvir (VEL)
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: CDI-31244|DRUG: SOF/VEL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analysis of the Coagulopathy Developed by COVID-19 Infected Patients
Status: COMPLETED
Conditions: Sepsis|Blood Coagulation Disorders|Thrombin|Disseminated Intravascular Coagulation|COVID-19
Interventions: OTHER: Thrombin generation test assay|OTHER: Fibrin generation markers assays
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: B-MAD Chemotherapy in Newly-diagnosed Extranodal NK/ T-cell Lymphoma
Status: COMPLETED
Conditions: Extranodal NK/T-cell Lymphoma
Interventions: DRUG: B-MAD chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pursed Lip Breathing Exercise and Laughter Therapy Individuals With The COPD
Status: NOT_YET_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Pursed Lip Breathing Exercise|OTHER: Laughter Therapy|OTHER: the control group.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ASIS for Botox in Upper Limb Spasticity
Status: UNKNOWN
Conditions: Upper Limb Spasticity Unilaterally in Adults With History of Stroke|Increased Muscle Tone in Elbow, Wrist, Finger, and Thumb Flexors.
Interventions: DRUG: Gadolinium|DRUG: Gadolinium|DRUG: Gadolinium|DRUG: Efficacy of Botox intramuscularly at Week 6|DRUG: Efficacy of Botox intramuscularly at Week 12,|DRUG: Efficacy of Botox intramuscularly at Week 18|DRUG: Efficacy of Botox intramuscularly at Week 24|DRUG: Efficacy of Botox intramuscularly at Week 30|DRUG: Efficacy of Botox subdermally at Week 6|DRUG: Efficacy of Botox subdermally at Week 12|DRUG: Efficacy of Botox subdermally at Week 18|DRUG: Efficacy of Botox subdermally at Week 24|DRUG: Efficacy of Botox subdermally at Week 30|DRUG: Adverse Reactions of Botox intramuscularly|DRUG: Adverse Reactions of Botox subdermally
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of the Safety and Immunogenicity of the COVID-19 Vaccine (mRNA-1273) in Participants With Hematologic Malignancies and Various Regimens of Immunosuppression, and in Participants With Solid Tumors on PD1/PDL1 Inhibitor Therapy
Status: COMPLETED
Conditions: Solid Tumor Malignancy|Hematologic Malignancy|Leukemia|Lymphoma|Multiple Myeloma
Interventions: BIOLOGICAL: Messenger ribonucleic acid (mRNA)-1273 Vaccine|BIOLOGICAL: Messenger ribonucleic acid (mRNA)-1273 Vaccine Booster|DIAGNOSTIC_TEST: ECG|OTHER: Antibiotics|OTHER: Anti-viral agents|OTHER: Anti-fungal agent|OTHER: Anti-emetics
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Inhaled Mometasone to Promote Reduction in Vasoocclusive Events 2
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: Placebo|DRUG: Mometasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reduction of the Glycemic Index by a Novel Viscous Polysaccharide
Status: COMPLETED
Conditions: Blood Glucose, Postprandial
Interventions: DIETARY_SUPPLEMENT: PolyGlycopleX (PGX)|DIETARY_SUPPLEMENT: PolyGlycopleX (PGX)|DIETARY_SUPPLEMENT: PolyGlycopleX (PGX)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Multiple Gingival Recession Defects Using a New Xenogenic Collagen Membrane Compared to Connective Tissue Graft: a Randomized Controlled Split-mouth Clinical Study
Status: RECRUITING
Conditions: Gingival Recession
Interventions: PROCEDURE: Treatment of gingival recessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone and Wound Healing After Thyroid Surgery
Status: COMPLETED
Conditions: Wound Infection
Interventions: DRUG: Dexamethasone|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety, Tolerability and Efficacy of AIN457 in Patients With Relapsing-remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: AIN457|DRUG: AIN457
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Open-label, Single-dose Study to Investigate The Pharmacokinetics Between a GL2907 XL and Oxycontin CR Tab. 10mg in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxycodone|DRUG: Oxycodone|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: CentriMag Ventricular Assist System in Treating Failure-to-Wean From Cardiopulmonary Bypass for Pediatric Patients
Status: WITHDRAWN
Conditions: Heart Failure
Interventions: DEVICE: CentriMag Ventricular Assist System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Air Insufflation, Water Immersion and Water Exchange Colonoscopy in Diagnostic Patients
Status: COMPLETED
Conditions: Pain|Colorectal Adenomas|Colorectal Cancer
Interventions: OTHER: Air Insufflation method.|OTHER: Water Immersion method.|OTHER: Water Exchange method.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label, Single Dose Pharmacokinetic Study of Benefix (Recombinant Factor IX) in Male Chinese Subjects With Hemophilia B
Status: COMPLETED
Conditions: Hemophilia B
Interventions: DRUG: BENEFIX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Insomnia Care As Usual to Digital Augmentation (CICADA)
Status: RECRUITING
Conditions: Chronic Insomnia
Interventions: BEHAVIORAL: COAST-enhanced CBTI|BEHAVIORAL: Military Treatment Facility Insomnia Care As Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transplantation With Ybritumomab Tiuxetan (Zevalin) Plus BEAM Regimen in Patients With Refractory Large B-cell Difusse Lymphom
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Ybritumomab Tiuxetan (Zevalin); Rituximab; BEAM (BCNU, ARAC, VP16 and Melphalan)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Family Procedural Presence
Status: ACTIVE_NOT_RECRUITING
Conditions: Patient and Family Engagement
Interventions: PROCEDURE: Families Invited to Be Present at Procedures|OTHER: Placebo/Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of SNAGS Along With Thoracic Postural Correction Techniques in Patients With Chronic Cervicogenic Headache
Status: COMPLETED
Conditions: Cervicogenic Headache
Interventions: OTHER: sustained natural apophyseal glides|OTHER: SNAGS with thoracic postural correction techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RCT: Mindfulness for Social Work and Self-care
Status: COMPLETED
Conditions: Burnout, Professional|Mindfulness|Stress, Psychological|Behaviour
Interventions: BEHAVIORAL: Mindfulness-Based Social Work and Self Care (MBSWSC)|BEHAVIORAL: Mindfulness-Based Self-Care (MBSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetics Study of Zolpidem Hemitartarate Orodispersible Tablet 3.5 mg Formulation
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: zolpidem hemitartarate tablet 3.5 mg (fasting + post-prandial)|DRUG: zolpidem hemitartarate tablet 3.5 mg (post-prandial + fasting)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Walking Exercise Sustainability Through Telehealth for Veterans With Lower-limb Amputation
Status: RECRUITING
Conditions: Lower-Limb Amputation
Interventions: BEHAVIORAL: Exercise self-management|BEHAVIORAL: Attention control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bacterial Overgrowth Associated With Chronic Multisymptom Illness Complex
Status: UNKNOWN
Conditions: Gulf War Syndrome
Interventions: PROCEDURE: Lactulose Breath Test|DRUG: Rifaximin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Diet Counseling for Low Calorie-High Protein on the Body Composition, Inflammation Marker, and Oxidative Stress Marker in Obese People With Weight Cycling
Status: UNKNOWN
Conditions: Low-Calorie Diet|Diet, High-Protein|Obesity; Pituitary|Weight Cycling
Interventions: BEHAVIORAL: diet counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Turoctocog Alfa Pegol (N8-GP) in Previously Untreated Patients With Haemophilia A
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A
Interventions: DRUG: turoctocog alfa pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of the Na-APR-1 Hookworm Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Hookworm Infection|Hookworm Disease
Interventions: BIOLOGICAL: Na-APR-1 (M74)/Alhydrogel®|BIOLOGICAL: Gluco-Pyranosylphospho-Lipid A Aqueous Formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of %6 HES 130/0.4 and %4 Gelofusine Infusion on Kidney Function in the Living-donor Liver Transplantation
Status: COMPLETED
Conditions: Patients Undergoing Liver Transplantation
Interventions: DRUG: %6 HES and %4 Gelofusine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mindfulness Intervention for Overweight Primary Care Patients
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: BEHAVIORAL: TAU|BEHAVIORAL: TAU+MBHP|BEHAVIORAL: TAU+MB-EAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: HER2 Targeted HypoSti.CAR-T Cells in HER2 Positive Advanced Solid Tumors
Status: RECRUITING
Conditions: HER2 Positive Advanced Solid Tumors
Interventions: BIOLOGICAL: HypoSti.CAR-HER2 T cells|DRUG: Albumin-bound paclitaxel|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Aprotinin on Transfusion Requirements in Patients Undergoing Radical or Total Cystectomy
Status: TERMINATED
Conditions: Blood Loss, Surgical|Postoperative Hemorrhage
Interventions: DRUG: Trasylol (Aprotinin, BAYA0128)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does Midazolam Cause Effective Anterograde Amnesia in Orthopedic Surgeries?
Status: COMPLETED
Conditions: Anesthesia|Orthopedic Surgery
Interventions: DRUG: single-dose midazolam for sedation under spinal anesthesia.|DRUG: Double-dose midazolam for sedation under spinal anesthesia.|PROCEDURE: spinal anesthesia with no sedation.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Stationary Breast Tomosynthesis and 2-D Digital Mammography in Patients With Known Breast Lesions
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DEVICE: Stationary Carbon Nanotube X-ray Digital Breast Tomosynthesis Scanner
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: RESET Trial - Part 1 - A Phase 3 Trial in Subjects With Sjögren-Larsson Syndrome (SLS)
Status: COMPLETED
Conditions: Sjogren-Larsson Syndrome
Interventions: DRUG: ADX-102 1% Topical Dermal Cream (reproxalap)|DRUG: Vehicle of ADX-102 Topical Dermal Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy of Fractional Er:YAG Laser for Acne Scar
Status: COMPLETED
Conditions: Scar
Interventions: PROCEDURE: Er:YAG laser|PROCEDURE: Bipolar radiofrequency with diode laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Stretching Versus Static and Dynamic Cupping on Lumbar Range of Motion
Status: COMPLETED
Conditions: Stiffness; Spine
Interventions: OTHER: Static Cupping|OTHER: Dynamic Cupping|OTHER: Stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of BOTOX® (Botulinum Toxin Type A) in Patients With Urinary Incontinence Due to Neurogenic Detrusor Overactivity or Overactive Bladder in India
Status: COMPLETED
Conditions: Urinary Incontinence|Overactive Bladder
Interventions: BIOLOGICAL: botulinum toxin Type A
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tart Cherry Supplementation and Women's Bone Health Study
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal|Osteoporosis, Age-Related
Interventions: DIETARY_SUPPLEMENT: tart cherry juice concentrate is a commercial product provided by King Orchards (Central Lake, MI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Exercise to Prevent AnthraCycline-based Cardio-Toxicity Study 2.0 (EXACT2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer, Breast|Cardiotoxicity|Cardiovascular Diseases
Interventions: BEHAVIORAL: Aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optical Biopsy for Thoracic Lymph Nodes.
Status: COMPLETED
Conditions: Mediastinal Lymphadenopathy|Non-small Cell Lung Carcinoma|Sarcoidosis
Interventions: DEVICE: Needle based confocal laser endomicroscopy (nCLE)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 1 Study of Acalabrutinib in Japanese Adult Patients With Advanced B-cell Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Part1: Advanced B-cell Malignancies|Part2: r/rCLL and r/rMCL|Part3: Untreated CLL
Interventions: DRUG: Acalabrutinib|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effect of Normal Frequency-band and Infra-low Frequency Neurofeedback on Functional Brain Connectome
Status: RECRUITING
Conditions: Neurofeedback
Interventions: DEVICE: Real Neurofeedback|DEVICE: Sham Neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Meal Texture on Intake
Status: COMPLETED
Conditions: Eating Behavior
Interventions: OTHER: Meals served during breakfast with a wide range of different food textures|OTHER: Meals served during lunch with a wide range of different food textures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Garlic in Hyperlipidemia Caused by HAART
Status: WITHDRAWN
Conditions: HIV Infections|Hypercholesterolemia|Hypertriglyceridemia|Hyperglycemia
Interventions: DRUG: Garlic powder standardized to allicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Zepatier in Patients With Substance Use
Status: UNKNOWN
Conditions: Hepatitis C|Hiv|Coinfection, HIV|Substance Use Disorders
Interventions: DRUG: Elbasvir/Grazoprevir 50 MG-100 MG Oral Tablet [ZEPATIER]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Triamcinolone Acetonide Combined With Laser, Bevacizumab Combined With Laser Versus Laser Alone for the Treatment of Diffuse Non-tractional Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: OTHER: Grid laser|DRUG: Triamcinolone Acetonide|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine (HCQ) for Recurrent Pregnancy Loss
Status: WITHDRAWN
Conditions: Recurrent Pregnancy Loss|Miscarriage
Interventions: DRUG: Hydroxychloroquine (HCQ)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SPECT/CT for the Characterization of Renal Masses
Status: RECRUITING
Conditions: Kidney Neoplasm|Renal Mass
Interventions: PROCEDURE: Computed Tomography|OTHER: Questionnaire Administration|PROCEDURE: Single Photon Emission Computed Tomography|RADIATION: Technetium Tc-99m Sestamibi
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Manual and Rotatory Instrumentation Pulpectomy in Primary Mandibular Molars
Status: UNKNOWN
Conditions: Dental Pulp Disease
Interventions: PROCEDURE: Rotatory technique pulpectomy|PROCEDURE: Manual pulpectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nab-Sirolimus and Endocrine Therapy in Recurrent Low Grade Serous Ovarian Cancer (NARETO)
Status: NOT_YET_RECRUITING
Conditions: Low Grade Ovarian Serous Adenocarcinoma
Interventions: DRUG: nab-Sirolimus|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational vs. Ablative Treatment for Low-grade Squamous Intraepithelial Lesions.
Status: COMPLETED
Conditions: LSIL, Low-Grade Squamous Intraepithelial Lesions
Interventions: PROCEDURE: Ablative treatment|PROCEDURE: Expectant management
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Treatment of Intravitreal Ranibizumab, Focal/Grid Laser and Panretinal Photocoagulation in Patients With Diabetic Macula Edema
Status: COMPLETED
Conditions: Diabetic Macula Edema
Interventions: PROCEDURE: Photocoagulation|DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Tegaserod vs. Placebo on Whole Gut Transit Time in Patients With Chronic Constipation and Dyspepsia
Status: WITHDRAWN
Conditions: Constipation and Dyspepsia
Interventions: DRUG: Tegaserod and Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Using Healthcare Financing and Digital Technology to Improve Hypertension Prevention and Control in Tanzania
Status: NOT_YET_RECRUITING
Conditions: Hypertension|Diabetes
Interventions: OTHER: Nurse-delivered care using WelTel check-ins and BCC SMS|OTHER: Community-based peer-support model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety Study of GB-0998 for Treatment of Generalized Myasthenia Gravis
Status: COMPLETED
Conditions: Generalized Myasthenia Gravis
Interventions: BIOLOGICAL: GB-0998 (Intravenous immunoglobulin)|PROCEDURE: Plasmapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Predict the Need for Humidification Use and Comparison of the Effect of ThermoSmart™ and no Humidification on Adherence
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DEVICE: ICON Auto CPAP™ with Thermosmart heated tube|DEVICE: ICON Auto CPAP™ without Thermosmart heated tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab Combined With Preoperative Chemotherapy (Albumin Paclitaxel+Carboplatin) Neoadjuvant Therapy for Resectable Locally Advanced (Stage II/III) Esophageal Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Esophageal Cancer
Interventions: DRUG: Combination of pembrolizumab and platinum containing dual drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spouse READI (Resilience Education And Deployment Information) Post Deployment Telephone Support Groups
Status: COMPLETED
Conditions: Spouses|Military Personnel|Coping Skills
Interventions: BEHAVIORAL: Telephone Discussion Groups|BEHAVIORAL: Education sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Use of a New Phototherapy Device (BBloo®) for the Treatment of Hyperbilirubinemia in the Newborn Infant
Status: UNKNOWN
Conditions: Neonatal Hyperbilirubinemia
Interventions: DEVICE: two sessions of 4 hours Phototherapy treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapist-guided vs Self-guided CBT for AD: Non-inferiority Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Atopic Dermatitis
Interventions: BEHAVIORAL: Therapist-guided cognitive behavioral therapy administered online|BEHAVIORAL: Self-guided digital intervention based on cognitive behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Endometriosis Patients Undergoing Quinagolide Treatment
Status: COMPLETED
Conditions: Hyperprolactinemia|Endometriosis
Interventions: PROCEDURE: ENDOMETRIAL BIOPSY
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Stereotactic Body Radiation Therapy in Treating Patients With Localized Prostate Cancer That Have Undergone Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: PSA Level Greater Than 0.03|PSA Progression|Stage I Prostate Adenocarcinoma AJCC (American Joint Committee on Cancer ) v7|Stage II Prostate Adenocarcinoma AJCC v7|Stage III Prostate Adenocarcinoma AJCC v7
Interventions: DRUG: Antiandrogen Therapy|OTHER: Quality-of-Life Assessment|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate Efficacy and Safety of of Autologous Mesenchymal Stem Cells (MSC) Injected Intracavernously
Status: RECRUITING
Conditions: Erectile Dysfunction
Interventions: BIOLOGICAL: Cellgram-ED
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Pharmaceutical Care in the Adherence of Systemic Lupus Erythematosus Treatment
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus|Medication Adherence
Interventions: OTHER: Pharmaceutical Care|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Periodic Fasting for Treatment of Long Covid in Adults: a Pilot Study
Status: NOT_YET_RECRUITING
Conditions: Long Covid|Chronic Inflammation
Interventions: OTHER: 7-day ambulatory caloric restriction intervention using the Buchinger-Wilhelmi method
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase Ib Study of Neoadjuvant of Cetuximab Plus Motolimod and Cetuximab Plus Motolimod Plus Nivolumab
Status: TERMINATED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Motolimod|DRUG: Cetuximab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Niraparib in Melanoma With Genetic Homologous Recombination (HR) Mutation
Status: UNKNOWN
Conditions: Metastatic Melanoma
Interventions: DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long-Term Prospective Randomized Controlled Study Using Repetitive Education at Six-Month Intervals and Monitoring for Adherence in Heart Failure Outpatients - The REMADHE Study
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: Disease Program Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intranasal Versus Nebulized Midazolam in Behaviuor Modification of Preschool Children Undergoing Dental Treatment
Status: COMPLETED
Conditions: Dental Sedation
Interventions: DRUG: Nebulized Midazolam|DRUG: Intranasal Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of the Electrocardiographic Effects of Ranolazine, Dofetilide, Verapamil, and Quinidine in Healthy Subjects
Status: COMPLETED
Conditions: Drug-induced Surface ECG Changes
Interventions: DRUG: Ranolazine|DRUG: Dofetilide|DRUG: Verapamil|DRUG: Quinidine sulfate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study on Autologous Tumor Infiltrating Lymphocytes Injection (GC101 TIL) for the Treatment of Advanced Malignant Solid Tumors
Status: RECRUITING
Conditions: Tumor Infiltrating Lymphocytes|Safety|Advanced Solid Tumor|Immunotherapy|Efficacy|Adverse Drug Event
Interventions: DRUG: TIL therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing FAS/ARND in Russian Children
Status: COMPLETED
Conditions: Fetal Alcohol Syndrome (FAS)|Fetal Alcohol Spectrum Disorders|Alcohol Abuse in Pregnancy
Interventions: BEHAVIORAL: Dual-Focused Brief Physician Intervention (DFBPI)|OTHER: Services as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Pilot Study of the Use of 129Xe and 1H MRI to Measure the Modulation of Eosinophil-Related Inflammation by Mepolizumab In COPD
Status: RECRUITING
Conditions: COPD
Interventions: DRUG: Mepolizumab 100 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the GTR Procedure Alone and in Combination With Immediate OTM
Status: COMPLETED
Conditions: Intrabony Periodontal Defect
Interventions: PROCEDURE: Guided tissue regeneration (GTR)|DEVICE: Orthodontic tooth movement (OTM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Examine The Effects Of Lapatinib On Orally And Intravenously Administered Midazolam In Cancer Patients
Status: COMPLETED
Conditions: Neoplasms, Breast
Interventions: DRUG: Midazolam|DRUG: Lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib or Carfilzomib With Lenalidomide and Dexamethasone in Treating Patients With Newly Diagnosed Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Plasma Cell Myeloma
Interventions: DRUG: Bortezomib|DRUG: Carfilzomib|DRUG: Dexamethasone|OTHER: Laboratory Biomarker Analysis|DRUG: Lenalidomide|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Colloid vs Crystalloid in Patients Undergoing Colorectal Surgery
Status: TERMINATED
Conditions: Surgery, Colorectal
Interventions: DRUG: balanced 6% hydroxyethylstarch 130/0.4|DRUG: balanced crystalloid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Value of Red Grapes Polyphenol Supplementation on Metabolic Parameters in Obese Insulinoresistant Subjects
Status: COMPLETED
Conditions: Obesity|Insulin Resistance|Menopause
Interventions: OTHER: Supplementation with red grapes polyphenol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Guselkumab in Skin of Color Participants With Moderate-to-severe Plaque and/or Scalp Psoriasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Plaque Psoriasis|Scalp Psoriasis
Interventions: DRUG: Guselkumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Older Patients With Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: CHOP regimen|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: prednisone|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: BOTOX® Intravesical Instillation in Participants With Overactive Bladder and Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence|Overactive Bladder With Urinary Incontinence
Interventions: DRUG: OnabotulinumtoxinA and Hydrogel admixture|DRUG: Placebo and Hydrogel admixture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a New HA Filler in Correcting Nasolabial Fold
Status: COMPLETED
Conditions: Aging Problems
Interventions: DRUG: CUREAⓇ (ARIBIO, Ltd., Seoul, Republic of Korea)|DRUG: JuvedermⓇ (Q-Med AB, Uppsala, Sweden)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Longitudinal Changes in Left and Right Ventricular Global Strain After Chemotherapy in Cardiac Light Chain Amyloidosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Amyloid Cardiomyopathy|Congestive Heart Failure|Chemotherapy Effect
Interventions: DIAGNOSTIC_TEST: Left and Right Ventricular Global Strain Imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Long-term Moderate Intervention With n-3 LC-PUFA-supplemented Dairy Products in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DIETARY_SUPPLEMENT: n-3 LC-PUFA|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of D-2570 in Participants With Moderate-to-Severe Plaque Psoriasis
Status: RECRUITING
Conditions: Plaque Psoriasis
Interventions: DRUG: D-2570|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Treatment With Serplulimab，Trastuzumab and SOX in the HER-2 Positive GC/GEJC
Status: NOT_YET_RECRUITING
Conditions: HER2-positive Gastric Cancer
Interventions: DRUG: Serplulimab|DRUG: Trastuzumab|DRUG: Oxaliplatin + Tegafur
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interim FDG PET-CT in Melanoma Metastatic Patient's Treated by Anti-PD1 Therapy
Status: RECRUITING
Conditions: Metastatic Melanoma
Interventions: DIAGNOSTIC_TEST: FDG PET-CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Assess the Efficacy, Safety, and Tolerability of Oral LPCN 1148 in Male Subjects With Cirrhosis of the Liver and Sarcopenia
Status: COMPLETED
Conditions: Liver Cirrhosis|Sarcopenia
Interventions: DRUG: LPCN 1148|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Amygdala Memory Enhancement
Status: RECRUITING
Conditions: Brain Diseases|Epilepsy|Memory Disorders|Traumatic Brain Injury|Cognitive Impairment|Post Traumatic Stress Disorder
Interventions: DEVICE: Intracranial Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects Of Therapeutic Plasma Exchange (TPE) On Age Related Biomarkers And Epigenetics
Status: ACTIVE_NOT_RECRUITING
Conditions: Aging
Interventions: DEVICE: Sham|DEVICE: Therapeutic Plasma Exchange|DRUG: IVIG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Evaluation of the Pharmacokinetics of Antituberculosis Drugs and Tuberculosis Treatment Outcomes
Status: UNKNOWN
Conditions: AIDS With Tuberculosis
Interventions: DRUG: Rifampicin, Isoniazid, Ethambutol, Pyrazinamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT