pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Nivolumab With or Without Ipilimumab in Treating Patients With Refractory Metastatic Anal Canal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Anal Canal Squamous Cell Carcinoma|Metastatic Anal Canal Carcinoma|Stage IV Anal Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|BIOLOGICAL: Ipilimumab|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Corneal Endothelial Cell Loss After Pneumatic Retinopexy for the Repair of Primary Rhegmatogenous Retinal Detachment
Status: UNKNOWN
Conditions: Rhegmatogenous Retinal Detachment
Interventions: PROCEDURE: Pneumatic retinopexy|PROCEDURE: vitrectomy|DRUG: sulfur hexafluoride (SF6)|DEVICE: 5/8-in 25-gauge needle|DEVICE: laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Types II or III
Status: TERMINATED
Conditions: Spinal Muscular Atrophy Type II|Spinal Muscular Atrophy Type III
Interventions: DRUG: sodium phenylbutyrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phytoestrogens and Breast Cancer - Effects of Phytoestrogens on Markers of Disease Progression and Gene Expression
Status: WITHDRAWN
Conditions: Breast Cancer|Breast Neoplasms|Breast Cancer Female
Interventions: DIETARY_SUPPLEMENT: Soy isoflavones|DIETARY_SUPPLEMENT: Lignans|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Chemo +/- Low-dose Radiation as Induction Therapy in SCCHN
Status: COMPLETED
Conditions: Head and Neck Cancer|Larynx
Interventions: RADIATION: Low dose fractionated radiation - 80cGy with chemotherapy|DRUG: Docetaxel and Carboplatin AUC 6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Organ Level Uptake Repeatability of 124I AT-01 in Subjects With Systemic Amyloidosis
Status: COMPLETED
Conditions: Amyloidosis
Interventions: DRUG: I124-AT01 only
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors, AZD3759 or AZD9291, in Patients Who Have Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: EGFR Mutation Positive Advanced Non Small Cell Lung Cancer
Interventions: DRUG: AZD3759|DRUG: AZD9291
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Study the Effects of Nanoparticle Based Paclitaxel Drug, Which Does Not Contain the Solvent Cremophor, in Advanced Breast Cancer
Status: UNKNOWN
Conditions: Advanced Breast Cancer
Interventions: DRUG: Nanoxel (Paclitaxel Nanoparticle formulation )
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Pomegranate Seed Oil Prevention and Progression Pressure Ulcers in Intensive Care Patients
Status: NOT_YET_RECRUITING
Conditions: Pressure Ulcer
Interventions: OTHER: topical pomegranate seed oil|OTHER: Sesame oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CAR-T Therapy for Central Nervous System B-cell Acute Lymphocytic Leukemia
Status: RECRUITING
Conditions: B-cell Acute Lymphocytic Leukemia
Interventions: BIOLOGICAL: CD19 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iliac Crest Bone Graft Harvesting for Pediatric Pelvic Osteotomy
Status: COMPLETED
Conditions: Child|Osteotomy
Interventions: PROCEDURE: two-sided approaches for iliac crest bone graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neuronal Correlates of Altered States of Consciousness
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LSD|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Diatermy in Patients With Fibromyalgia.
Status: NOT_YET_RECRUITING
Conditions: Fibromyalgia
Interventions: OTHER: Diathermy|OTHER: Simulated Diathermy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety of Rituximab Retreatment in Subjects With Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Lupus Erythematosus, Systemic
Interventions: DRUG: Rituximab|DRUG: Placebo|DRUG: Prednisone|DRUG: Acetaminophen|DRUG: Diphenhydramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trebananib in Treating Patients With Advanced Angiosarcoma That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Adult Angiosarcoma|Recurrent Adult Soft Tissue Sarcoma|Stage III Adult Soft Tissue Sarcoma|Stage IV Adult Soft Tissue Sarcoma
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Trebananib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of High Viscosity Glass Ionomer Strip Crowns in Primary Maxillary Incisors
Status: ACTIVE_NOT_RECRUITING
Conditions: Early Childhood Caries
Interventions: OTHER: Pediatric Strip Crown and High Viscosity Glass Ionomer Cement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Retina in Mechanisms of Illusions and Visual Hallucinations Observed in Idiopathic Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson's Disease|Visual Hallucinations
Interventions: DIAGNOSTIC_TEST: Optical Coherence Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Vitamin K on Redness Associated With Injection Site Reactions in Participants Treated With Plegridy
Status: COMPLETED
Conditions: Relapsing-Remitting Multiple Sclerosis
Interventions: OTHER: Vitamin K Cream|OTHER: Placebo Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of 10-day Concomitant Regimen Versus High Dose Dual Therapy in Anti-Helicobacter Pylori Rescue Therapy
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: high dose dual therapy|DRUG: concomitant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Clinical Trial of a Candidate PCV13 in Healthy People Aged 6 Weeks and Above (PICTPCV13i)
Status: COMPLETED
Conditions: Pneumococcal Infections|Streptococcal Infections|Bacterial Infections
Interventions: BIOLOGICAL: 13-Valent Pneumococcal Polysaccharide Conjugate Vaccine（CRM197,TT）|BIOLOGICAL: 13-Valent Pneumococcal Polysaccharide Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optimizing Brachytherapy Application and Delivery With MRI Guidance for Gynecologic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Gynecologic Cancer
Interventions: DEVICE: MRI|RADIATION: Brachytherapy|DEVICE: MRI Tracker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Non-Malignant Hematological Disorders in Children
Status: RECRUITING
Conditions: Hemoglobinopathy (Disorder)|Severe Aplastic Anemia|Bone Marrow Failure Syndrome
Interventions: BIOLOGICAL: Haploidentical Hematopoietic Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ablation of Complex Fractionated Electrograms With or Without Additional Linear Lesions for Persistent Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation|Recurrence
Interventions: PROCEDURE: PVI+CFAE+DCC|PROCEDURE: PVI, CFAE, anterior and roof line, DCC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home-Based Exercise as an Intervention to Treat Decreased Physical Function in Patients With Varying Levels of Kidney Function
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Kidney Disease
Interventions: BEHAVIORAL: 8 week home-based exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Perioperative Chemotherapy for Patients With Locally Advanced Bladder Cancer
Status: UNKNOWN
Conditions: Bladder Cancer
Interventions: DRUG: GEMCITABINE CISPLATINE|DRUG: METHOTRXATE VINBLASTINE DOXORUBICINE CISPLATINE G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Primary and Metastatic Brain Tumor Hypoxia With Fluoromisonidazole, FDG and Water
Status: TERMINATED
Conditions: Brain Cancer
Interventions: DRUG: [18F]fluoro-2-deoxy-D-glucose (FDG)|DRUG: 1H-1-(3-[18F]-fluoro-2-hydroxy-propyl)-2-nitro-imidazole [18F]-fluoromisonidazole|DRUG: [15O]water|DIAGNOSTIC_TEST: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Long-term Effects of Combined Balance and Brisk Walking in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: Combined balance and brisk walking training|BEHAVIORAL: Flexibility and strengthening exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Infiltration in the Region of the Palatine Ganglion Spheno by Ropivacaine on Postoperative Pain
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: ropivacaine|DRUG: saline solution 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Pharmacokinetics of Cabozantinib (XL184) in Hepatic Impaired Adult Subjects
Status: COMPLETED
Conditions: Healthy|Hepatic Impairment
Interventions: DRUG: cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Color-Doppler Ultrasonography to Assess the Renal Blood Flow With the Estimation of GFR
Status: UNKNOWN
Conditions: Hypertension|Renal Failure
Interventions: PROCEDURE: Color-Doppler Ultrasound, 99mTc-DTPA scintigraphy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neurocognition in Congenital Central Hypoventilation Syndrome (CCHS)
Status: RECRUITING
Conditions: Congenital Central Hypoventilation Syndrome|Congenital Central Hypoventilation|CCHS|CCHS With Hirschsprung Disease|CCHS With Neural Crest Tumor|CCHS With Neuroblastoma
Interventions: OTHER: NIH Toolbox Cognition Battery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Which is More Effective in Management of Bruxism: Botox or Occlusal Splints
Status: COMPLETED
Conditions: Bruxism
Interventions: DEVICE: overdenture|DEVICE: occlusal splint|DRUG: Botox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Periodontitis and Adverse Pregnancy Outcomes in Metabolic Syndrome Patients- Interventional Study
Status: UNKNOWN
Conditions: Low Birth Weight Baby|Metabolic Syndrome|Pregnancy Complications|Adverse Pregnancy Outcomes|Periodontitis|Premature Birth
Interventions: PROCEDURE: Comprehensive periodontal treatment|PROCEDURE: single visit supragingival scaling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bisphosphonate-coated Dental Implants
Status: COMPLETED
Conditions: Edentatio (Toothlessness)
Interventions: DEVICE: Dental implant coating with a fibrinogen carrier for pamidronate and ibandronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Effective and Compliance Regimen of Paclitaxel Plus Cisplatin to Treat Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Breast Neoplasms
Interventions: DRUG: PhyxolTM, Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quality of Life in Caregivers of Hospitalized Older Patients With Cancer
Status: COMPLETED
Conditions: Hematopoietic/Lymphoid Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: OTHER: questionnaire administration|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Comparison Study of Intralesional Botulinum Toxin A and Corticosteroid Injection for Alopecia Areata
Status: UNKNOWN
Conditions: Alopecia Areata
Interventions: DRUG: Botulinum toxin type A|DRUG: Triamcinolone acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Sleeve Gastrectomy With or Without Hiatal Hernia Repair in Morbidly Obese Patients
Status: RECRUITING
Conditions: Morbid Obesity|Hiatal Hernia|Gastroesophageal Reflux Disease|Sleeve Gastrectomy
Interventions: PROCEDURE: Laparoscopic sleeve gastrectomy + Hiatal hernia repair|PROCEDURE: Laparoscopic sleeve gastrectomy alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Finger Prick Whole Blood MITRA Assay Method With the Established Venepuncture Whole Blood Method for Quantitative Determination of Tacrolimus Blood Concentrations in Transplant Patients
Status: COMPLETED
Conditions: Kidney Transplantation|Liver Transplantation
Interventions: DRUG: tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Hypnosis Versus SIVOC by Remifentanil During TAVI Procedures : Iloact on Peripoperative Confusion
Status: UNKNOWN
Conditions: Confusion
Interventions: PROCEDURE: TAVI : Transcatether Aortic Valve Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Investigation of Therapeutic Efficacy and Safety of UMSCs for the Management of Retinitis Pigmentosa (RP)
Status: UNKNOWN
Conditions: Retinitis Pigmentosa (RP)
Interventions: BIOLOGICAL: Injection of stem cells in sub-tenon space of eye for the management of retinitis pigmentosa|BIOLOGICAL: Injection of stem cells in suprachoroidal space of eye for the management of Retinitis Pigmentosa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Regadenoson Administration Following an Inadequate Exercise Stress Test as Compared to Regadenoson Alone for Myocardial Perfusion Imaging (MPI) Using Single Photon Emission Computed Tomography (SPECT)
Status: COMPLETED
Conditions: Coronary Artery Disease (CAD)
Interventions: DRUG: Regadenoson|PROCEDURE: Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Drug-Drug Interaction Study With PF-05089771
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pravastatin, midazolam, losartan, omeprazole, caffeine and PF-05089771
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Flexible Dose Brexpiprazole as Monotherapy or Combination Therapy in the Treatment of Adults With Post-traumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic
Interventions: DRUG: Brexpiprazole|DRUG: Sertraline|DRUG: Brexpiprazole Matching Placebo|DRUG: Sertraline Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Epacadostat (INCB24360) in Combination With Sirolimus in Advanced Malignancy
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumor|Non-small Cell Lung Cancer (NSCLC)
Interventions: DRUG: Epacadostat|DRUG: sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Assess the Plaque and Gingivitis Effects of a Stannous Fluoride Dentifrice
Status: COMPLETED
Conditions: Gingivitis
Interventions: DRUG: Marketed Toothpaste|DRUG: Marketed Cavity Protection Toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clearance of NRL972 in Patients With Cirrhosis, Nonalcoholic Steatohepatitis (NASH) and in Healthy Volunteers
Status: COMPLETED
Conditions: Hepatic Cirrhosis|Nonalcoholic Steatohepatitis
Interventions: DRUG: NRL972|DRUG: NRL972|DRUG: NRL972|DRUG: NRL972|DRUG: NRL972|DRUG: NRL972|DRUG: NRL972
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cataract Monitored Anesthesia Care (MAC) Feasibility Pilot Study
Status: RECRUITING
Conditions: Cataract|Bilateral Senile Cataract|Anesthesia|Patient Satisfaction
Interventions: PROCEDURE: Oral sedation|PROCEDURE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effects of Mindfulness-based Training in Undergraduate Students of Translation and Interpreting
Status: COMPLETED
Conditions: Psychological Distress|Life Stress|Anxiety|Perfectionism|Emotional Intelligence|Creativity|Attention|Empathy
Interventions: BEHAVIORAL: The CRAFT program (adapted due to COVID-19)|BEHAVIORAL: The MBSR program (adapted due to COVID-19)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of the Alga Dunaliella Bardawil as a Source of 9-cis Retinoic Acid on Lipid Profile in Fibrate Treated Patients.
Status: COMPLETED
Conditions: Low HDL Cholesterol
Interventions: DRUG: Dunaliella
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose:
Clinical trial: A Video Intervention to Improve Patient Understanding of Tumor Genomic Testing in Patients With Metastatic Cancer
Status: RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Breast Carcinoma|Metastatic Lung Carcinoma|Metastatic Malignant Solid Neoplasm|Prognostic Stage IV Breast Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: BEHAVIORAL: Health Education|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sonographic Evaluation of the Effect of Shoulder Orthosis on the Subluxation in Stroke Patients
Status: COMPLETED
Conditions: Stroke Patients
Interventions: DEVICE: actimove sling|DEVICE: shoulderlift
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preimplant Site Augmentation Using MPM Versus Autogenous Bone Graft
Status: UNKNOWN
Conditions: Bone Resorption
Interventions: OTHER: Mineralized plasmatic matrix (MPM).|OTHER: Autogenous bone graft (gold standard).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Lipoic Acid on Ischemic Heart Failure
Status: UNKNOWN
Conditions: Ischemic Heart Failure
Interventions: DRUG: Alpha-Lipoic Acid(α-LA)|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study)
Status: COMPLETED
Conditions: Transposition of the Great Vessels|Hypoplastic Left Heart Syndrome|Oxygen Consumption Based Assessment of Hemodynamics
Interventions: DEVICE: General Electric Healthcare E-COVX Gas Monitoring Module for VO2 Measurments|DEVICE: Edwards Continuous SVO2 Catheter and Monitoring System - 4.5 fr
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mobile Contingency Management for Smoking Cessation in Returning US Veterans
Status: COMPLETED
Conditions: Smoking|Veterans
Interventions: OTHER: Nicotine gum|BEHAVIORAL: mobile contingency management|BEHAVIORAL: Telephone counseling|OTHER: Nicotine patch|OTHER: Nicotine lozenge|OTHER: Smart phone|OTHER: Carbon monoxide monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pharmacokinetics, Pharmacodynamics, Safety of BCD-131 Compared to Mircera and Aranesp in Healthy Volunteers
Status: COMPLETED
Conditions: Reticulocyte Count
Interventions: BIOLOGICAL: BCD-131|BIOLOGICAL: Mircera®|BIOLOGICAL: Aranesp®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of L-Thyroxine on Lipid Profiles and Atherosclerosis in Subclinical Hypothyroidism
Status: UNKNOWN
Conditions: Hypothyroidism|Thyroid Diseases|Endocrine System Diseases
Interventions: DRUG: L-thyroxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Targeted Educational Interventions at Increasing HPV Vaccine Acceptability and Uptake
Status: COMPLETED
Conditions: HPV-Related Cervical Carcinoma
Interventions: OTHER: Educational video|OTHER: Educational handout|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Trial of n-3 PUFA-Enriched Ready to Use Therapeutic Food for Childhood Severe Malnutrition
Status: COMPLETED
Conditions: Severe Acute Malnutrition
Interventions: DIETARY_SUPPLEMENT: RUTF/Flax Oil|DIETARY_SUPPLEMENT: RUTF/Flax Oil plus additional Fish Oil|DIETARY_SUPPLEMENT: Standard RUTF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mixed Exercise Training and Novel Multi-Nutrient Supplementation in Young Adults
Status: WITHDRAWN
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Multi-nutrient supplement|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Research Study to Compare Three Doses of Semaglutide Tablets Taken Once Daily in People With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Oral semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alpha-linolenic Acid and Blood Pressure
Status: COMPLETED
Conditions: Hypertension|Lipid Metabolism Disorders
Interventions: DIETARY_SUPPLEMENT: Flaxseed oil|DIETARY_SUPPLEMENT: high oleic sunflower oil (HOSF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Low Dose Cyclophosphamide +/-- Nintedanib in Advanced Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Fallopian Tube Cancer
Interventions: DRUG: BIBF 1120
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Auto BMT for Non-M3 AML in 1st Remission in Pts </=60y of Age Using Busulfan/FTBI & VP16 as a Prep R
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: filgrastim|DRUG: busulfan|DRUG: cytarabine|DRUG: etoposide|DRUG: idarubicin|PROCEDURE: autologous hematopoietic stem cell transplantation|PROCEDURE: bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: total-body irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: QUILT-3.080: NANT Pancreatic Cancer Vaccine
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: Aldoxorubicin HCl|BIOLOGICAL: ALT-803|BIOLOGICAL: ETBX-011|BIOLOGICAL: ETBX-021|BIOLOGICAL: ETBX-051|BIOLOGICAL: ETBX-061|BIOLOGICAL: GI-4000|BIOLOGICAL: GI-6207|BIOLOGICAL: GI-6301|BIOLOGICAL: haNK for infusion|BIOLOGICAL: bevacizumab|DRUG: Capecitabine|DRUG: Cyclophosphamide|DRUG: Fluorouracil|DRUG: Leucovorin|DRUG: nab-Paclitaxel|DRUG: Oxaliplatin|BIOLOGICAL: Avelumab|PROCEDURE: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Changing to DuoTrav in Patients Uncontrolled on Timolol
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Travoprost 0.004%/timolol maleate 0.5% fixed combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Goal-directed vs Preemptive Tranexamic Acid Administration in Total Hip Arthroplasty
Status: NOT_YET_RECRUITING
Conditions: Arthritis of Hip
Interventions: DRUG: Tranexamic Acid|DIAGNOSTIC_TEST: thromboelastography|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Efficacy of MOAP Regimen for Relapsed/Refractory cHL as a Rescue Therapy After DP Regimen
Status: UNKNOWN
Conditions: Hodgkin Lymphoma
Interventions: DRUG: MOAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Efficiency of Screening for Neurodevelopmental Disorders by an Advanced Practice Nurse in Children With Congenital Heart Disease
Status: RECRUITING
Conditions: Congenital Heart Disease in Children|Neurodevelopmental Disorders
Interventions: OTHER: Screening for neurodevelopmental disorders by an advanced practice nurse
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rituximab Followed by Combination Chemotherapy in Treating Patients With Refractory or Recurrent Non-Hodgkin's Lymphoma
Status: WITHDRAWN
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|BIOLOGICAL: sargramostim|DRUG: EPOCH regimen|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: prednisone|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety Study That Compares Perlane to Perlane With Lidocaine (Perlane-L) While Correcting Wrinkles in the Area Around Your Nose
Status: COMPLETED
Conditions: Nasolabial Folds
Interventions: DEVICE: Perlane and Perlane-L
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Substantial Equivalence Study of RD04723 and Predicate Device
Status: UNKNOWN
Conditions: Hypertrophic Scar|Keloid Scar
Interventions: DEVICE: RD047-023|DEVICE: Predicate Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone in Lower Third Molar Surgery
Status: COMPLETED
Conditions: Impacted Third Molar Tooth
Interventions: PROCEDURE: Intramuscular application|PROCEDURE: Submucosal application|DRUG: 4mg Dexamethasone submucosal|DRUG: 8mg Dexamethasone submucosal|PROCEDURE: 4mg Dexamethasone preoperative|PROCEDURE: 4mg Dexamethasone postoperative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Broad Band Emission LED Phototherapy Source Versus Narrow Band
Status: UNKNOWN
Conditions: Neonatal Hyperbilirubinemia|Jaundice, Neonatal
Interventions: DEVICE: Blue-Green LED photoherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PRF With Topical Antibiotics or Antiseptics in Chronical Wounds Version 1.4
Status: RECRUITING
Conditions: Chronic Skin Ulcer
Interventions: DRUG: PRF mixed with amikacin and teicoplanin|DRUG: PRF mixed with PHMB plus Macrogolol|DRUG: PRF plus normal saline|OTHER: Silver gauze
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RESTIT : Evaluation of Resorbable Osteosynthesis Devices Versus Titanium in Maxillofacial Surgery
Status: UNKNOWN
Conditions: Maxillo-Facial Surgery
Interventions: DEVICE: Resorbable device PLLA/PGA|DEVICE: Titanium device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid Acting Transcranial Magnetic Stimulation
Status: RECRUITING
Conditions: Treatment Resistant Depression
Interventions: DEVICE: Active TBS-DLPFC|DEVICE: Sham TBS-DLPFC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of PTC299 (Emvododstat) in Relapsed/Refractory Acute Leukemias
Status: TERMINATED
Conditions: Leukemia, Myeloid, Acute|AML
Interventions: DRUG: PTC299
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Skin Barrier Dysfunction and the Role of Skin Barrier Restoration
Status: TERMINATED
Conditions: Cutaneous Inflammation
Interventions: OTHER: Vanicream Moisturizing Skin Cream|OTHER: Vanicream Cleansing Soap
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Immunosuppression Drug Weaning on Hepatitis C Virus (HCV)-Induced Liver Damage After Liver Transplantation
Status: COMPLETED
Conditions: Hepatitis C Virus Infection|Liver Transplantation
Interventions: PROCEDURE: Gradual immunosuppression drug withdrawal.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Research Site Bile Acid Sequestrant Acceptability (BASA) Scale Pilot Validation Study
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cholestyramine|DRUG: Cholestyramine|DRUG: Tang
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prospective Multicenter Clinical Study of Neoadjuvant Imatinib Mesylate for Gastrointestinal Stromal Tumors
Status: RECRUITING
Conditions: Progression-free Survival|Gastrointestinal Stromal Tumor|Neoadjuvant
Interventions: DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Clinical Trial of Crizotinib for Children and Adults With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Neurofibromatosis 2|Progressive Vestibular Schwannoma (VS)
Interventions: DRUG: Crizotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Ascension® Humeral Resurfacing Arthroplasty Follow-Up Study
Status: TERMINATED
Conditions: Shoulder Arthritis Osteoarthritis|Rheumatoid Arthritis Shoulder|Acquired Deformity of Head|Post-traumatic Arthrosis of Other Joints, Shoulder Region
Interventions: DEVICE: Ascension HRA device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib After Progression on Atezolizumab-bevacizumab in Hepatocellular Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treat COVID-19 Patients With Regadenoson
Status: COMPLETED
Conditions: COVID-19|Lung Inflammation
Interventions: DRUG: Regadenoson|OTHER: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of HIIT on Cardiopulmonary Function After PCI in Patients With Coronary Heart Disease
Status: RECRUITING
Conditions: Coronary Heart Disease
Interventions: BEHAVIORAL: high-intensity interval training|BEHAVIORAL: Moderate-intensity continuous training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Yogurt Enriched With Flaxseed on Cardiovascular Risk Factors in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: low fat yogurt enriched with flaxseed|DIETARY_SUPPLEMENT: low fat yogurt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Benefit of CoQ-10 in Patients on Statins
Status: COMPLETED
Conditions: Pain|Soreness|Weakness|Fatigue
Interventions: DIETARY_SUPPLEMENT: Co-enzyme Q-10|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: I-gel vs AuraGain for Bronchoscopic Intubation Through SGA
Status: COMPLETED
Conditions: Airway Management
Interventions: DEVICE: Bronchoscopic intubation through AuraGain LMA|DEVICE: Bronchoscopic intubation through I-gel SGA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Acute Cognitive, Mood and Autonomic Effects of Hops in Healthy Participants
Status: COMPLETED
Conditions: Mood Modulation|Modulation of Cognition
Interventions: DIETARY_SUPPLEMENT: Hops Extract|OTHER: Placebo (silica)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Modality on Discharge Instruction in Patients Receiving Outpatient Antibiotic Prescriptions From the Emergency Department
Status: COMPLETED
Conditions: Modality of Discharge Instructions
Interventions: OTHER: Text Message|OTHER: Voicemail
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Complex Contraception Registry
Status: COMPLETED
Conditions: Diabetes|Cardiovascular Disease|Epilepsy|Migraine|Neurological Disorders|Cancer|Bariatric Surgery Candidate|Organ or Tissue Transplant; Complications|Lupus Erythematosus, Systemic|Other Hematologic Conditions|Other Venous Embolism and Thrombosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Test Whether Spesolimab Helps People With Generalized Pustular Psoriasis (GPP) Who Need Treatment for Repeated Flares
Status: RECRUITING
Conditions: Generalized Pustular Psoriasis
Interventions: DRUG: Spesolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Precision-Based Magnesium Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: Magnesium glycinate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Irinotecan/Capecitabine Versus Capecitabine in Patients Treated With A/T for HER2 Negative Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Irinotecan, Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Assessing Efficacy and Safety of OC-10X in the Treatment of PDR
Status: TERMINATED
Conditions: Proliferative Diabetic Retinopathy (PDR)
Interventions: DRUG: 2% OC-10X|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Prescribed Exercise on Pain Related Fear Following Concussion in Collegiate Athletes: A Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Concussion, Brain
Interventions: BEHAVIORAL: Treadmill Walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Aspirin as an add-on Treatment of Refractory Epilepsy in Tuberous Sclerosis Complex
Status: UNKNOWN
Conditions: Tuberous Sclerosis Complex|Aspirin|Epilepsy|Cognitive Decline|Skin Lesions
Interventions: DRUG: Aspirin|DRUG: AED|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Curcumin in Preventing Colorectal Cancer in Patients Undergoing Colorectal Endoscopy or Colorectal Surgery
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: curcumin|OTHER: high performance liquid chromatography|OTHER: laboratory biomarker analysis|OTHER: pharmacological study|PROCEDURE: diagnostic endoscopic procedure|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Comparison of Zero- and Two-centimeter Distance From Sapheno-femoral Junction in Laser Ablation of Varicose Vein
Status: ACTIVE_NOT_RECRUITING
Conditions: Varicose Veins|Venous Reflux|Venous Insufficiency|Venous Leg Ulcer
Interventions: PROCEDURE: Saphenous Ablation|DEVICE: Endogenous Laser Ablation (EVLA)|DRUG: mixture of 20 mL 2% lidocaine, 1: 200,000 adrenaline and 20 mL 0.5% levobupivacaine in 1 L of 0.9% saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Visual Outcomes and Patient Satisfaction After Bilateral Implantation of Non-diffractive EDOF IOL Made of a New Hydrophobic Acrylic Material
Status: TERMINATED
Conditions: Cataract
Interventions: DEVICE: Clareon Vivity extended depth of focus (EDOF) intraocular lens
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Glucagon Like Peptide (GLP)-1 in Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: liraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial Comparing MBSR to SET in Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Neoplasms
Interventions: BEHAVIORAL: Mindfulness Meditation-Based Stress Reduction|BEHAVIORAL: Supportive-Expressive Group Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Phase 1 Study of IMP321 (Eftilagimod Alpha) Adjuvant to Anti-PD-1 Therapy in Unresectable or Metastatic Melanoma
Status: COMPLETED
Conditions: Stage IV Melanoma|Stage III Melanoma
Interventions: DRUG: IMP321 (eftilagimod alpha)|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Growth and Metabolic Biomarkers of Healthy Term Infants Fed Formulas With Staged Protein Concentrations Over the First Year of Life
Status: COMPLETED
Conditions: Healthy Term Infants
Interventions: DIETARY_SUPPLEMENT: Formula regimen 1|DIETARY_SUPPLEMENT: Formula regimen 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of Safety and Efficacy of BF-200 ALA for the Treatment of Actinic Keratosis With Photodynamic Therapy
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: BF-200 ALA|DRUG: MAL Cream|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intermittent Androgen Deprivation Therapy With or Without Stereotactic Body Radiotherapy for Molecularly Identified Hormone Sensitive Oligometastatic Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: SBRT|DRUG: Hormone therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on the Control of Chronic Obstructive Pulmonary Disease (COPD) in Patients Taking the Combination of Tiotropium and Olodaterol Using the Respimat® Inhaler
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Spiolto® Respimat®
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dihydroartemisinin-piperaquine for Seasonal Malaria Chemoprophylaxis in Tanzania
Status: COMPLETED
Conditions: Malaria|Chemoprophylaxis|Underfive Children
Interventions: DRUG: Dihydroartemisinin-piperaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison Tympanoplasty With Membrane Amniotic and Autologous Fascia
Status: COMPLETED
Conditions: Tympanic Membrane Perforation
Interventions: PROCEDURE: device: Tympanoplasty with Membrane Amniotic|PROCEDURE: Tympanoplasty With Autologous Fascia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Application of Spectral Methods to Assess Gametes, Embryos, and Human Reproductive Capabilities
Status: RECRUITING
Conditions: Infertility
Interventions: OTHER: making artificial intelligence based decisions of gamete, embryo and endometrial potential
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Retinyl Palmitate-loaded Ethosomes in Acne Vulgaris
Status: COMPLETED
Conditions: Facial Acne Vulgaris
Interventions: DRUG: retinyl palmitate|DRUG: Tretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Omeza Combination Therapy With Standard of Care to Standard of Care Alone for Chronic Venous Leg Ulcers
Status: COMPLETED
Conditions: Venous Leg Ulcer
Interventions: DEVICE: Omeza® OCM™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and PK of CRN04894 for the Treatment of Cushing's Syndrome
Status: RECRUITING
Conditions: Cushing Syndrome|Cushing Disease|Ectopic ACTH Syndrome
Interventions: DRUG: CRN04894
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT