pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparison of CIMT and Its Modified Form on Upper Motor Function Outcomes in Hemiplegic Cerebral Palsy.
Status: COMPLETED
Conditions: Hemiplegic Cerebral Palsy
Interventions: OTHER: Classic CIMT group|OTHER: Modified CIMT group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Drug-eluting Ureteral Stent on Bacterial Adherence and Biofilm Formation
Status: COMPLETED
Conditions: Renal Calculi|Ureteral Obstruction
Interventions: DEVICE: Ureteral Stent|DEVICE: Ureteral Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Probiotic Yoghurt Effect on Experimental Gingivitis
Status: COMPLETED
Conditions: Gingivitis
Interventions: DIETARY_SUPPLEMENT: Probiotic Yoghurt|DIETARY_SUPPLEMENT: Natural Yoghurt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Symptom-based Rehabilitation Compared to Usual Care in Post-COVID - a Randomized Controlled Trial
Status: COMPLETED
Conditions: COVID-19|Long-COVID
Interventions: OTHER: symptom-focused rehabilitation|OTHER: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Vaccine (CIMAvax-EGF) for the Prevention of Lung Cancer Development or Recurrence
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|Lung Non-Small Cell Carcinoma|Pneumonia|Stage IB Lung Cancer AJCC v8|Stage II Lung Cancer AJCC v8|Stage IIA Lung Cancer AJCC v8|Stage IIB Lung Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8
Interventions: OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|BIOLOGICAL: Recombinant Human EGF-rP64K/Montanide ISA 51 Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Drug-Drug Interaction Study of Omeprazole and PA21
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PA21 and Omeprazole with food|DRUG: No PA21; Omeprazole with food|DRUG: PA21 with food, Omeprazole 2hrs later
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Zinc Supplementation on Markers of Oxidative Stress in Post Operative Colorectal Cancer During Chemotherapy Cycles
Status: COMPLETED
Conditions: Chemotherapy|Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: Zinc|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Feasibility Study of Allium's Biliary Stent
Status: WITHDRAWN
Conditions: Malignant Obstruction of the Common Bile Duct
Interventions: DEVICE: Allium Biliary Stent|DEVICE: allium biliary stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xarelto for Prevention of Stroke in Patients With Atrial Fibrillation in Latinamerica and EMEA Region
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mulligan Mobilization vs Transverse Friction Massage in Rotator Cuff Syndrome
Status: COMPLETED
Conditions: Rotator Cuff Syndrome
Interventions: OTHER: Mulligan Mobilzation|OTHER: Trasverse Friction Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Clinical Trial on DH001 Tablets in the Prevention of Doxorubicin-induced Cardiotoxicity in Cancer Patients
Status: RECRUITING
Conditions: Cancer|Heart Failure|Arrhythmia|Doxorubicin Induced Cardiomyopathy|Doxorubicin Adverse Reaction
Interventions: DRUG: Control group:DH001 placebo|DRUG: Trial group: DH001 low-dose group|DRUG: Trial group: DH001 high-dose group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Therapeutic Hypothermia in "Expanded Criteria" Brain-dead Donors and Kidney-graft Function
Status: COMPLETED
Conditions: Organ Donor|Brain Death|Kidney Transplant; Complications|Critical Illness|Hypothermia
Interventions: PROCEDURE: Procedure control: normothermia|PROCEDURE: Procedure active
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Volumetric Analysis of Root Resorption With Mini-Screw Implant Anchorage-assisted Retraction of Maxillary Incisors
Status: UNKNOWN
Conditions: Dental Dysgnathia
Interventions: DEVICE: Mini-Screw implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastro-laryngeal Tube During Transesophageal Echocardiography
Status: COMPLETED
Conditions: Anesthesia|Sedation|Analgesia|Airway Complication of Anesthesia
Interventions: OTHER: Number of attempts for successful transesophageal echocardiography|DIAGNOSTIC_TEST: A questionnaire for cardiologist satisfaction|DIAGNOSTIC_TEST: A questionnaire for patient satisfaction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: MgSO4 vs Metoclopramide for Headache in Pregnant Women
Status: WITHDRAWN
Conditions: Headache
Interventions: DRUG: magnesium sulfate|DRUG: metoclopramide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Memory Enhancement by Gamma-hydroxybutyrate vs. Trazodone in Major Depressive Disorder.
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: GHB|DRUG: Trazodone|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Open Laparoscopic and Robotic Surgery in Gastric Cancer Resection.
Status: UNKNOWN
Conditions: Stomach Neoplasms
Interventions: PROCEDURE: laparotomy|PROCEDURE: Laparoscopic|PROCEDURE: Robotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Interventional Study Assessing Response to Cytarabine, Daunorubicin and Etoposide (ADE) for First Relapse of Paediatric Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia, in Relapse
Interventions: DRUG: ADE Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Major Cardiovascular Events in Participants With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant Treated With Bempedoic Acid (ETC-1002) or Placebo
Status: COMPLETED
Conditions: Cardiovascular Diseases|Statin Adverse Reaction
Interventions: DRUG: Bempedoic acid 180 mg tablet|DRUG: Matching placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Phase II Study of PET Guided Neoadjuvant Chemotherapy (NAC) and Oncotype Guided Hormonal Therapy of Breast Cancer"
Status: UNKNOWN
Conditions: Infiltrating Duct and Lobular Carcinoma In Situ|Invasive Lobular Breast Carcinoma|Inflammatory Breast Carcinoma
Interventions: DRUG: Docetaxel, Epirubicin, Cyclophosphamide/Navelbine, Capecitabine, Trastuzumab, Bevacizumab|DRUG: Docetaxel, Epirubicin, Cyclophosphamide/Navelbine, Capecitabine, Trastuzumab, Bevacizumab|DRUG: Docetaxel, Epirubicin, Cyclophosphamide/Navelbine, Capecitabine, Trastuzumab, Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare Effects of EpiCor and Vitamin C to Vitamin C Alone on the Common Cold or Influenza in Healthy Children
Status: COMPLETED
Conditions: Signs and Symptoms, Respiratory
Interventions: DIETARY_SUPPLEMENT: EpiCor and Vitamin C|DIETARY_SUPPLEMENT: Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluate the Safety of DEXYCU for the Treatment of Inflammation Following Ocular Surgery for Childhood Cataract
Status: RECRUITING
Conditions: Cataract
Interventions: DRUG: Dexamethasone|DRUG: Prednisolone Acetate Ophthalmic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PARP-inhibitor on Advanced Metastatic Breast Cancer in Germline PALB2 Mutations Carriers
Status: NOT_YET_RECRUITING
Conditions: Metastatic Breast Cancer in Germline-PALB2 Mutations Carriers
Interventions: DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AZD2066 Cocktail Study
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DRUG: AZD2066|DRUG: Caffeine|DRUG: Tolbutamide|DRUG: Omeprazole Tablet, 20 mg|DRUG: Midazolam Tablet, 7.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Incretin-based Therapy in Late Preclinical Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Victoza®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oxaliplatin and Docetaxel for Recurrent or Metastatic Head and Neck Cancer
Status: TERMINATED
Conditions: Neoplasms|Head and Neck Neoplasms
Interventions: DRUG: Oxaliplatin and Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide, Insulin Degludec and Liraglutide in Japanese Subjects With Type 2 Diabetes Mellitus.
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec/liraglutide|DRUG: insulin degludec|DRUG: liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pecans on Biomarkers of Risk for Cardiovascular Disease and Diabetes
Status: COMPLETED
Conditions: Cardiovascular Disease Risk|Type 2 Diabetes Risk
Interventions: OTHER: Pecan-containing diet|OTHER: Nut-free diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Exosomal and Free Extracellular RNAs and Proteins as Predictive Biomarkers for HER2 Therapies in Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|HER2 Positive Breast Cancer|HER2 Negative Breast Cancer
Interventions: OTHER: Biomarker Analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase II Study of Cobimetinib in Combination With Vemurafenib in Active Melanoma Brain Metastases
Status: TERMINATED
Conditions: Active Melanoma Brain Metastases
Interventions: DRUG: Cobimetinib|DRUG: Vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Registry of the Combination of Antiplatelet Agents and Anticoagulant in Atrial Fibrillation Patients With a CHA2DS2VASc Score >1 Undergoing Percutaneous Coronary Interventions
Status: UNKNOWN
Conditions: Percutaneous Coronary Intervention
Interventions: OTHER: the prevalence of ischemic events
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Stereotactic Radiosurgery to the Subventricular Zone in Malignant Gliomas
Status: WITHDRAWN
Conditions: Glioblastoma|Astrocytoma, Grade III|Astrocytoma, Grade IV|Malignant Glioma
Interventions: RADIATION: Stereotactic Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smile Arc Assessment in Orthodontic Patients Following Smile Arc Protection VS MBT Placement Guide Bonding Strategies
Status: UNKNOWN
Conditions: Orthodontic Appliance Complication
Interventions: DEVICE: 18 inch slot MBT orthodontic brackets bonded using smile arc protection bonding strategy|DEVICE: 18 inch slot MBT orthodontic brackets boned using MBT placement guide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DIStinguishing ChildrEn at Low Risk of Severe infectioN in Case of Febrile Neutropenia-7: Impact Study of a Clinical Decision Rule
Status: RECRUITING
Conditions: Neutropenia, Febrile
Interventions: PROCEDURE: The Clinical Decision Rule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Impact of PM+For Moms Intervention on Improving Mother's Mental Health in Zambia (PM+FM)
Status: COMPLETED
Conditions: Depressive Symptoms|Anxiety|Trauma, Psychological
Interventions: BEHAVIORAL: Problem Management + For Moms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Non-surgical Periodontal Therapy on Adverse Birth Outcomes Randomized Controlled Trial
Status: COMPLETED
Conditions: Birth Weight|Birth, Preterm
Interventions: PROCEDURE: NSPT plus oral hygiene|OTHER: Oral hygiene alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Multicenter Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Lumateperone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Two Once Daily Anti Retroviral Treatment Regimens Along With Anti-tuberculosis Treatment
Status: UNKNOWN
Conditions: Tuberculosis|Human Immunodeficiency Virus Infections
Interventions: DRUG: Didanosine, Lamivudine, Efavirenz|DRUG: Didanosine, Lamivudine, Nevirapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-flow Nasal Oxygen Therapy in Obese Patients Undergoing Sedative Gastroscopy
Status: NOT_YET_RECRUITING
Conditions: Hypoxia|Obesity|Gastrostomy
Interventions: BEHAVIORAL: jaw lift, increasing oxygen flow, mask ventilation, intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study of the BARD® COVERA™ Arteriovenous (AV) Stent Graft in AV Graft Patients (AVeVA)
Status: COMPLETED
Conditions: Stenosis|Restenosis
Interventions: DEVICE: Covera(TM) Vascular Covered Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Factor VIIa in Acute Intracerebral Haemorrhage
Status: COMPLETED
Conditions: Acquired Bleeding Disorder|Intracerebral Haemorrhage
Interventions: DRUG: eptacog alfa (activated)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RefleXion PET/CT Imaging Performance in Patients With Various Malignancies
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid System Neoplasm|Malignant Solid Neoplasm
Interventions: PROCEDURE: Computed Tomography|OTHER: Fludeoxyglucose F-18|OTHER: Medical Device Usage and Evaluation|DEVICE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Using fMRI-guided TMS to Increase Central Executive Function in Older Adults (MCI_Sub)
Status: TERMINATED
Conditions: Mild Cognitive Impairment
Interventions: DEVICE: rTMS|DEVICE: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immunotherapy Using Pluripotent Killer-Programmed Cell Death 1 (PIK-PD-1) Cells for the Treatment of Advanced Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Advanced Hepatocellular Carcinoma
Interventions: BIOLOGICAL: PIK-PD-1 cells|BIOLOGICAL: DC-PMAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects Aquatic Exercises on Balance and Hand Function in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: OTHER: Halliwick|OTHER: Aquatic Plyometric Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SP TLF Versus Ho:YAG Laser
Status: RECRUITING
Conditions: Urinary Calculi
Interventions: DEVICE: Laser lithotripsy (SP TLF)|DEVICE: Laser lithotripsy (Ho:YAG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Ectopic Cushing Syndrome
Status: RECRUITING
Conditions: ACTH|Cushing's Syndrome
Interventions: RADIATION: DOTATATE PET-CT|RADIATION: F-DOPA PET CT|RADIATION: CT scan|DIAGNOSTIC_TEST: Routine MRI scan|DIAGNOSTIC_TEST: Gated MRI scan|DRUG: 68Ga-DOTATATE|DRUG: 18F-DOPA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Reversal of Neuromuscular Blockade With Sugammadex Versus Neostigmine Plus Glycopyrolate in Patients Undergoing Burn Surgery
Status: COMPLETED
Conditions: Burns
Interventions: DRUG: Sugammadex|DRUG: Neostigmine|DRUG: Glycopyrrolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TAK-659 in Combination With Bendamustine (+/-Rituximab), Gemcitabine, Lenalidomide, or Ibrutinib for the Treatment of Participants With Advanced Non-Hodgkin Lymphoma
Status: TERMINATED
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: TAK-659|DRUG: Bendamustine|DRUG: Rituximab|DRUG: Gemcitabine|DRUG: Lenalidomide|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Initiating Tiotropium Alone Versus Initiating Tiotropium in Combination With Fluticasone Propionate/Salmeterol Xinafoate Combination (FSC) on Chronic Obstructive Pulmonary Disease-related Outcomes in Patients With Pre-existing Exacerbations
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: TIO|DRUG: TIO+FSC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Comparing Perceptions and Satisfaction for Two Different Delivery Mechanisms for Etanercept
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DEVICE: Enbrel 50 mg Prefilled Syringe|DEVICE: Enbrel 50 mg Autoinjector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate 3 Dose Schedules of Daratumumab in Participants With Smoldering Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: daratumumab|DRUG: daratumumab|DRUG: daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Understanding Factors in Decision Making for Children With Medical Complexity
Status: RECRUITING
Conditions: Multiple Chronic Conditions|Children With Medical Complexity
Interventions: BEHAVIORAL: Ambiguity|BEHAVIORAL: Complexity|BEHAVIORAL: Normalizing language|BEHAVIORAL: Narrative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy And Safety Evaluation of Glepaglutide in Treatment of Short Bowel Syndrome (SBS)
Status: COMPLETED
Conditions: Short Bowel Syndrome
Interventions: DRUG: glepaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Elaboration of a Pre-surgery Mapping Protocol of Primary Motor Cortex, Prior to an Implementation of a Stimulation of Primary Motor Cortex for Patients With Deafferentiation of Brachial Plexus Pain
Status: TERMINATED
Conditions: Painful Avulsion of Brachial Plexus
Interventions: PROCEDURE: fMRI|PROCEDURE: mTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation in Children and Adolescents
Status: UNKNOWN
Conditions: Haploidentical Hematopoietic Stem Cell Transplantation|Malignant Disease|Non-malignant Disease
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|BIOLOGICAL: anti-thymocyte globulin|BIOLOGICAL: filgrastim|RADIATION: Total body irradiation|PROCEDURE: TCRαβ-depleted hematopoietic cell transplantation|DEVICE: CliniMACS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Meals to Improve Absorption of Iron Supplements
Status: RECRUITING
Conditions: Iron-deficiency|Iron Deficiency Anemia|Iron Deficiency Anemia Treatment
Interventions: OTHER: Iron supplement with a lunch meal containing beef|OTHER: Iron supplement with a lunch meal containing plant-based alternative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Epidural Block With Adding Sciatic Block to Continuous Femoral Block in Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: PROCEDURE: epidural infusion|PROCEDURE: femoral sciatic|DEVICE: epidural infusion|DEVICE: femoral sciatic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Interrupting Prolonged Sitting With Intermittent Exercise on Postprandial Lipemia
Status: COMPLETED
Conditions: Metabolic Syndrome X|Atherosclerosis|Insulin Resistance|Hyperinsulinism|Glucose Metabolism Disorders|Metabolic Disease|Arteriosclerosis|Arterial Occlusive Diseases|Vascular Diseases|Cardiovascular Diseases
Interventions: BEHAVIORAL: Prolonged sitting without exercise|BEHAVIORAL: Prolonged sitting with interval exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of 6% Hydroxyethyl Starch 130/0.4 on Blood Loss and Coagulation in Patients Medicated With Antiplatelet Agents Prior to Off-Pump Coronary Bypass Graft Surgery
Status: COMPLETED
Conditions: Coronary Artery Occlusive Disease
Interventions: DRUG: 6% hydroxyethyl Stach 130/0.4
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Two Dose Epidural Morphine for Post-cesarean Analgesia
Status: TERMINATED
Conditions: Pain|Morphine Adverse Reaction
Interventions: DRUG: Epidural Morphine|DRUG: Epidural Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Oxytocin Treatment on Social Touch
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Intranasal oxytocin|DRUG: Oral oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Further MT for AntIbiotic-Resistant Bacterial Colonization in Inpatients
Status: RECRUITING
Conditions: Multi-drug Resistant Organism
Interventions: DRUG: Microbiome Therapeutic|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Socket Grafting for Alveolar Ridge Preservation
Status: COMPLETED
Conditions: Atrophy of Edentulous Alveolar Ridge
Interventions: PROCEDURE: Tooth extraction and grafting with allograft|PROCEDURE: Tooth extraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Omega-3 Fatty Acid on Endothelial Function
Status: COMPLETED
Conditions: Familial Hypercholesterolemia
Interventions: DRUG: Omega-3|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neuro/Sacituzumab Govitecan/Breast Brain Metastasis/Glioblastoma/Ph 0
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: Sacituzumab Govitecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Silicone Oil on Nerve Fiber Layer Thickness After Pars Plana Vitrectomy
Status: COMPLETED
Conditions: Rhegmatogenous Retinal Detachment|Toxic Effect of Silicone|Glaucoma Due to Silicon Oil
Interventions: OTHER: Optical coherence tomography|DRUG: Local medical treatment of raised intraocular pressure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Ranolazine in Blood Markers in Women With Angina and Metabolic Syndrome
Status: COMPLETED
Conditions: Stable Angina|Metabolic Syndrome
Interventions: DRUG: Ranolazine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Magnetic Fields to Treat Alzheimer's Disease
Status: WITHDRAWN
Conditions: Alzheimer's Disease
Interventions: DEVICE: Resonator|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Behavioral Graded Activity in Patients With Osteoarthritis of the Hip and/or Knee
Status: UNKNOWN
Conditions: Osteoarthritis
Interventions: BEHAVIORAL: Behavioral graded activity|OTHER: Exercise therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Postop Rehab Methods on Outcomes Following Reverse Shoulder Arthroplasty
Status: WITHDRAWN
Conditions: Rotator Cuff Tear Arthropathy|Shoulder Osteoarthritis
Interventions: BEHAVIORAL: Patient-led rehab with short immobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive, Morphological and Neurobiological Progressive Aspects in Bipolar Disorders in the Elderly: Toward to a Neurodegenerescence Detection?
Status: UNKNOWN
Conditions: Senile Plaques|Tau Proteins|Alzheimer Disease|Bipolar Disorders|Mild Cognitive Impairment
Interventions: PROCEDURE: Lombar Punction|RADIATION: Magnetic Resonance Imaging (MRI)|RADIATION: Positron-Emission Tomography (TEP) /(FDG)|OTHER: Psychiatric tests|OTHER: Neuropsychological Tests|GENETIC: Apolipoprotein (ApoE) detection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Electroacupuncture Plus Antiemetic Therapy for Chemotherapy-Induced Nausea and Vomiting in Patients With Breast Cancer
Status: RECRUITING
Conditions: Electroacupuncture|Olanzapine-contained Four-drug Antiemetic|Nausea and Vomiting
Interventions: DEVICE: Electroacupuncture|DRUG: Antiemetic Therapy|DEVICE: Sham electroacupuncture|DRUG: Antiemetic Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HPV Screening With Triage by HPV Genotyping Versus Visual Inspection With Acetic Acid
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: DIAGNOSTIC_TEST: HPV genotyping|DIAGNOSTIC_TEST: Visual inspection after application of acetic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Influence of Thymoglobuline on Phenotypic and Functional Profiles of B Lymphocytes in Renal Transplant Recipients
Status: UNKNOWN
Conditions: Renal Transplant
Interventions: DRUG: Thymoglobulin Induction|DRUG: Basiliximab Induction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Toleration and Efficacy of Single Inhaled Doses of PF-00610355 in Chronic Obstructive Pulmonary (COPD) Patients.
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: PF-00610355|DRUG: PF-00610355|DRUG: PF-00610355|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of an Alternative to Incarceration by Housing and Support by Assertive Community Treatment Team for Homeless People With Severe Psychiatric Disorders Referred to Immediate Referral Procedure: AILSI Program
Status: RECRUITING
Conditions: Severe Psychiatric Disorder
Interventions: OTHER: alternative to incarceration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Tele-ultrasound Experimentation: Cooperation Protocol Between Electro-radiology Assistant and Remote Radiologist
Status: TERMINATED
Conditions: Tele-ultrasound
Interventions: OTHER: Dual ultrasound reading "local vs remote"|OTHER: Dual ultrasound reading "local vs local"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sentinel Node Biopsy in Endometrial Cancer
Status: RECRUITING
Conditions: Endometrial Cancer Stage I|Sentinel Lymph Node|Surgery
Interventions: PROCEDURE: TH BSO with SNB Note: If participants (≤45yo), Grade 1 endometrial adenocarcinoma with myometrial invasion <50%, wish to retain their ovaries a BSO may be omitted|PROCEDURE: TH BSO without retroperitoneal node dissection Note: If participants (≤45yo), Grade 1 endometrial adenocarcinoma with myometrial invasion <50%, wish to retain their ovaries a BSO may be omitted
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR)
Status: RECRUITING
Conditions: Lymphoma, Non-Hodgkin|Multiple Myeloma|Advanced Solid Tumors
Interventions: DRUG: Olaparib|DRUG: Dasatinib|DRUG: Nivolumab plus Ipilimumab|DRUG: Axitinib|DRUG: Bosutinib|DRUG: Crizotinib|DRUG: Palbociclib|DRUG: Sunitinib|DRUG: Temsirolimus|DRUG: Erlotinib|DRUG: Trastuzumab plus Pertuzumab|DRUG: Vemurafenib plus Cobimetinib|DRUG: Vismodegib|DRUG: Tucatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MLN3126 in Healthy Japanese and Non-Japanese Participants
Status: TERMINATED
Conditions: Safety|Tolerability|Pharmacokinetics|Pharmacodynamics
Interventions: DRUG: MLN3126|DRUG: MLN3126 Matched Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ketorolac and Remote Ischemic Preconditioning on Renal Ischemia-reperfusion Injury in Patients Undergoing Partial Nephrectomy
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Ketorolac tromethamine and remote ischemic preconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Venetoclax Plus Azacitidine Versus Intensive Chemotherapy for Fit Patients With Newly Diagnosed NPM1 Mutated AML
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Venetoclax plus Azacitidine|DRUG: standard of care chemotherapy plus gemtuzumab ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Customized Silicone Digital Orthoses in People With Diabetic Neuropathy
Status: RECRUITING
Conditions: Diabetic Neuropathies
Interventions: DEVICE: Custom silicone digital orthosis (CSDO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Feasibility of an Oral Intervention for Sexual Health in Transgender Men
Status: RECRUITING
Conditions: Vaginal Dysbiosis|Vaginal Disease|Molecular-bacterial Vaginosis
Interventions: DIETARY_SUPPLEMENT: Probiotic Group|DIETARY_SUPPLEMENT: Placebo Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neutral Position Facilitates Orotracheal Intubation With Videolaryngoscopes
Status: WITHDRAWN
Conditions: Orotracheal Intubation
Interventions: DEVICE: McGrath laryngoscope|DEVICE: C-MAC D-blade laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Ondansetron on Cardiac Output in Elective Cesarean Deliveries
Status: COMPLETED
Conditions: Cardiac Output
Interventions: DRUG: Ondansetron|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Anti-inflammatory Effects of Harkány Medicinal Water
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Psoriasis
Interventions: OTHER: Harkány medicinal water|OTHER: Tap water (placebo control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Docetaxel for Injection (Albumin-bound) in Patients With Gastric Cancer
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Docetaxel for injection (Albumin-bound)|DRUG: Taxotere (docetaxel)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irinotecan and Gemcitabine in Treating Patients With Recurrent or Progressive Stage III or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-ranging Study to Assess Safety and Efficacy of SP-333 for the Treatment of Opioid-induced Constipation (OIC)
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: SP-333 1 mg|DRUG: SP-333 3 mg|DRUG: SP-333 6 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Specialist Treatment
Status: COMPLETED
Conditions: Binge-Eating Disorder|Obesity
Interventions: BEHAVIORAL: Cognitive-Behavioral Therapy (CBT)|DRUG: NB Medication (on-going from acute treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Population Versus Practice-based Interventions to Increase Immunizations
Status: COMPLETED
Conditions: Health Services Research|Comparative Effectiveness|Immunization
Interventions: BEHAVIORAL: Recall conducted by private practices|BEHAVIORAL: Recall conducted centrally by local health department
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Transplantation of Autologous Cardiac Stem Cells in Ischemic Heart Failure
Status: UNKNOWN
Conditions: Heart Failure
Interventions: BIOLOGICAL: Intracoronary injection|BIOLOGICAL: Intracoronary injection of Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Food Study of Nitrofurantoin Macrocrystals 100 mg Capsules and Macrodantin® 100 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Nitrofurantoin Macrocrystals 100 mg Capsules|DRUG: Macrodantin® 100 mg Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Lay Health Workers and Colorectal Cancer Screening Among Chinese Americans
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: BEHAVIORAL: LHWO about CRC|BEHAVIORAL: Nutrition Education + CRC brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Omission of Surgery in Clinically Low-risk HER2positive Breast Cancer With High HER2 Addiction and a Complete Response Following Standard Anti-HER2-based Neoadjuvant Therapy
Status: RECRUITING
Conditions: HER2-positive Breast Cancer|Stage I Breast Cancer
Interventions: BIOLOGICAL: Trastuzumab and pertuzumab Subcutaneous Fixed-Dose Combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sentinel Lymph Node (SLN) Biopsy for Conjunctival/Eyelid Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Eye Disease|Melanoma
Interventions: PROCEDURE: Sentinel Lymph Node Mapping and Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: AZD9291 Versus Placebo in Patients With Stage IB-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy.
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage IB-IIIA Non-small Cell Lung Carcinoma
Interventions: DRUG: AZD9291 80 mg/40 mg|DRUG: Placebo AZD9291 80 mg/40 mg|DRUG: Open-label AZD9291 80 mg/40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating a Natural Antioxidant Food Product on Oxidative Stress in Recreationally Active Participants
Status: COMPLETED
Conditions: Oxidative Stress|Exercise Recovery
Interventions: DIETARY_SUPPLEMENT: Antioxidant supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Lenalidomide in Combination With Sunitinib to Evaluate the Safety and Efficacy in Patients With Renal Cell Carcinoma
Status: TERMINATED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Lenalidomide|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Trans-tympanic Injections of a Sodium Thiosulfate Gel to Prevent Cisplatin-induced Ototoxicity
Status: TERMINATED
Conditions: DDP|Head and Neck Cancer|Adverse Effect
Interventions: DRUG: Trans-tympanic injection of a sodium thiosulfate gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioavailability of BI 1356 BS and Metformin After Co-administration Compared to the Bioavailability of BI 1356 BS Alone and Metformin Alone in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Metformin|DRUG: BI 1356 BS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GDC-0941 and Cisplatin in Treating Patients With Androgen Receptor-Negative Triple Negative Metastatic Breast Cancer
Status: TERMINATED
Conditions: Estrogen Receptor Negative Breast Cancer|Human Epidermal Growth Factor 2 Negative Carcinoma of Breast|Triple Negative Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer|Triple-negative Breast Cancer
Interventions: DRUG: cisplatin|OTHER: laboratory biomarker analysis|OTHER: pharmacological study|PROCEDURE: dynamic contrast-enhanced MRI, diffusion-weighted MRI & chemical exchange saturation transfer MRI|DRUG: GDC -0941
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of Solabegron Tablets for Treatment of Overactive Bladder in Adult Women
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: Solabegron immediate release tablets, low dose|DRUG: Solabegron immediate release tablets, high dose|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Neoadjuvant Immunotherapy in Early Stage Breast Cancer Before Standard Therapy
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Atezolizumab Injection|DRUG: Bevacizumab|DRUG: Pertuzumab|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Data Analyses for Ancillary WISE Femhrt Hormone Replacement Study
Status: COMPLETED
Conditions: Myocardial Ischemia
Interventions: DRUG: 1/10 NA/EE|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Reduction After Cholecystectomy
Status: COMPLETED
Conditions: Cholecystolithiasis|Postoperative Pain
Interventions: DRUG: Levobupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Palbociclib in Combination With Binimetinib for Patients With Advanced KRAS Mutant Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer
Interventions: DRUG: Binimetinib|DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Nasal Steroids in Snoring Intensity
Status: COMPLETED
Conditions: Snoring
Interventions: DRUG: nasal spray Budesonide|DRUG: Nasal spray Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Ertugliflozin in Asian Participants With Type 2 Diabetes and Inadequate Glycemic Control on Metformin Monotherapy (MK-8835-012)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Ertugliflozin 5 mg|DRUG: Ertugliflozin 15 mg|DRUG: Placebo matching ertugliflozin|DRUG: Metformin|DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety of Use of Intravitreal SOK583A1 Provided in a Prefilled Syringe
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration (nAMD)
Interventions: DRUG: SOK583A1 (40 mg/mL)|DEVICE: Prefilled Syringe (PFS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Subjects With Distal Renal Tubular Acidosis
Status: TERMINATED
Conditions: Distal Renal Tubular Acidosis
Interventions: DRUG: ADV7103|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence Study Comparing Clindamycin Phosphate (1.2%) and Tretinoin (0.025%) Topical Gel to Ziana and Placebo
Status: COMPLETED
Conditions: MILD TO SEVERE ACNE VULGARIS
Interventions: DRUG: CLIND PHOSPHATE (1.2%) AND TRETINOIN (0.025%) TOPICAL GEL|DRUG: ZIANA®|DRUG: Vehicle Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT