pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Hydoxycarbamide and L-Carnitine Therapy in Sickle Cell Anemia
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: Hydroxycarbamide 500 Mg Oral Capsule+L-Carnitine|DRUG: Hydroxycarbamide 500 Mg Oral Capsule|DRUG: L-Carnitine, 250 Mg Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psoas Compartment Block Versus Periarticular Local Anesthetic for Total Hip Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis|Arthroplasty
Interventions: DRUG: Ropivacaine with NaCl|DRUG: Epinephrine|DRUG: Morphine|DRUG: Ketorolac Tromethamine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Hyaluronic Acid and Free Gingival Graft Healing
Status: RECRUITING
Conditions: Hyaluronic Acid|Gingival Recession, Localized|Pain, Postoperative
Interventions: DRUG: Hyadent BG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Kinesiological / Dietary Supplement Intervention in Knee Osteoarthritis
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Non-training Real Dietary Supplement (G1)|OTHER: Training Placebo Dietary Supplement (G2)|OTHER: Training Real Dietary Supplement (G3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing Two Antibiotic Therapy Periods (3 Versus 7 Days) in Patients With Mild Leptospirosis and Seen at the Hospital in 5 French Overseas Departments (Martinique, Guadeloupe, French Guiana, Reunion, Mayotte)
Status: NOT_YET_RECRUITING
Conditions: Mild Leptospirosis
Interventions: DRUG: 3 days of antibiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of FOXP3 Gene Polymorphisms and Serum Interleukin 10 in Patients With ITP
Status: RECRUITING
Conditions: Thrombocytopenia
Interventions: DIAGNOSTIC_TEST: Serum IL10 By ELISA|DIAGNOSTIC_TEST: SNP -3279 A/C of FOXP3|DIAGNOSTIC_TEST: SNP-924 A/G Of FOXP3
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Testing Dabrafenib and Trametinib With or Without Hydroxychloroquine in Stage IIIC or IV BRAF V600E/K Melanoma
Status: TERMINATED
Conditions: Clinical Stage IV Cutaneous Melanoma AJCC v8|Locally Advanced Melanoma|Pathologic Stage IIIC Cutaneous Melanoma AJCC v8|Pathologic Stage IV Cutaneous Melanoma AJCC v8|Unresectable Melanoma
Interventions: DRUG: Dabrafenib mesylate|DRUG: Hydroxychloroquine|DRUG: Placebo Administration|DRUG: Trametinib dimethyl sulfoxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Carbohydrate Rinsing and Caffeine Gum on Performance of Romanian Deadlifts Performance
Status: COMPLETED
Conditions: Carbohydrate|Caffeine
Interventions: OTHER: Carbohydrate mouth rinsing|OTHER: 200 mg caffeine gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Optic Nerve Sheath Diameter on Retrobulbar Ultrasonography Before and After Drainage of Cerebrospinal Fluid in Pediatric Patient With Hydrocephalus
Status: UNKNOWN
Conditions: Hydrocephalus
Interventions: PROCEDURE: retrobulbar ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Medical Polypectomy and Predictors of Response
Status: COMPLETED
Conditions: Nasal Polyps
Interventions: DRUG: Prednisolone|DRUG: Placebo|OTHER: fluticasone nasal drops|OTHER: fluticasone nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Two Methods of Soft Tissue Augmentation for Socket Closure on Soft Tissue Landmarks and Ridge Dimensions
Status: COMPLETED
Conditions: Recession, Gingival
Interventions: PROCEDURE: P-CTG|PROCEDURE: CTG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Enhanced Dialysis Education (EDU) Intervention for Chronic Kidney Disease (CKD) Patients
Status: COMPLETED
Conditions: Chronic Kidney Diseases
Interventions: BEHAVIORAL: CKD-EDU|OTHER: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Haemochromatosis and Periodontitis
Status: COMPLETED
Conditions: to Evaluate the Prevalence of Periodontal Diseases in Patients With Hemochromatosis at the Time of Diagnosis and / or Their Usual Therapeutic
Interventions: DIAGNOSTIC_TEST: dental probes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: DynamX Bioadaptor Global Post-Market Registry: Clinical Trial of the Elixir Medical DynamX Novolimus Eluting Coronary Bioadaptor System
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: DynamX Novolimus-eluting Coronary Bioadaptor System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of AT7519M Alone and AT7519M Plus Bortezomib in Patients With Previously Treated Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: AT7519M|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Envafolimab Combined With Chemotherapy in Metastatic or Recurrent Gastric Adenocarcinoma
Status: RECRUITING
Conditions: Metastatic or Recurrent Gastric Adenocarcinoma
Interventions: DRUG: Envafolimab|DRUG: Oxaliplatin|DRUG: S1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Pharmacokinetics, Safety, and Tolerability of Nirsevimab in Healthy Chinese Adults
Status: COMPLETED
Conditions: Evaluate PK Profile
Interventions: BIOLOGICAL: nirsevimab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pecto-intercostal Fascial Plane Block for Postoperative Analgesia and Recovery Profile After Off-Pump Coronary Artery Bypass Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Ultrasound guided pecto-intercostal Fascial Plane Block using bupivacaine|PROCEDURE: Ultrasound guided pecto-intercostal Fascial Plane Block using normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clarithromycin Triple Therapy Plus Bismuth for Helicobacter Pylori First-line Treatment
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Esomeprazole|DRUG: Bismuth Potassium Citrate|DRUG: Clarithromycin|DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vonoprazan-Based Triple Therapy in Comparison With Extended Sequential Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Helicobacter Pylori
Interventions: DRUG: Vonoprazan-based triple therapy|DRUG: Extended sequential therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Advanced Renal Cell Carcinoma, With Failure or Unsuitable on Prior Interferon-alpha or Interleukin-2 Based Therapy
Status: TERMINATED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Sorafenib (Nexavar, BAY43-9006)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sertraline Hydrochloride 100 mg Tablets, Fasting
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Zoloft® 100 mg Tablets|DRUG: Sertraline hydrochloride 100 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Alemtuzumab Plus Fludarabine and Melphalan With or Without Cyclosporine, Mycophenolate Mofetil, and Low-Dose Total-Body Irradiation Therapy Followed by Donor Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer
Status: WITHDRAWN
Conditions: Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: BIOLOGICAL: alemtuzumab|DRUG: cyclosporine|DRUG: fludarabine phosphate|DRUG: melphalan|DRUG: mycophenolate mofetil|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Geriatric Hip Fractures Caregiver Programme
Status: UNKNOWN
Conditions: Geriatric Hip Fracture
Interventions: BEHAVIORAL: Empowering the patient and caregiver for early and safe discharge of patients with geriatric hip fractures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Study Comparing the Effects of Moxaverine on Ocular Blood Flow in Patients With Age- Related Macular Degeneration, Primary Open Angle Glaucoma and Healthy Control Subjects
Status: COMPLETED
Conditions: Macular Degeneration|Glaucoma|Regional Blood Flow
Interventions: DRUG: moxaverine|DRUG: moxaverine|DRUG: moxaverine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Brexucabtagene Autoleucel Plus Dasatinib in Adults With Acute Lymphoblastic Leukemia
Status: RECRUITING
Conditions: Lymphoblastic Leukemia
Interventions: DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estrogen Replacement and Atherosclerosis (ERA) in Older Women
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Arteriosclerosis|Coronary Disease|Heart Diseases|Myocardial Ischemia|Postmenopause
Interventions: DRUG: estrogen replacement therapy|DRUG: hormone replacement therapy|DRUG: estrogens|DRUG: progestins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: The Outcomes of ICSI Cycles With and Without Letrozole
Status: UNKNOWN
Conditions: EMBRYO IMPLANTATION
Interventions: DRUG: Letrozole 2.5Mg Tablet|DRUG: Gonadotropins|PROCEDURE: endometrial sample in the pretreatment cycle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of PRO95780 in Combination With Rituximab in Patients With Non-Hodgkin's Lymphoma That Has Progressed Following Previous Rituximab Therapy (APM4083g)
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: PRO95780|DRUG: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Pasteurized Goat Milk in the Treatment of Childhood Oral Ulcer Diseases
Status: COMPLETED
Conditions: Oral Ulcer
Interventions: BIOLOGICAL: Drinking or rinsing the mouth 2-3 times for 1 day|BIOLOGICAL: Pasturlized cow milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prognostic Factors to Regain Consciousness
Status: RECRUITING
Conditions: Neurologic Disorder|Disorder of Consciousness|Traumatic Brain Injury|Stroke|Hypoxic-Ischemic Encephalopathy
Interventions: DIAGNOSTIC_TEST: Coma-Recovery-Scale-Revised (CRS-R)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Interoceptive Exposure for Adolescents With Low Weight Eating Disorders
Status: RECRUITING
Conditions: Anorexia Nervosa
Interventions: BEHAVIORAL: Interoceptive Exposure Treatment (IE)|BEHAVIORAL: Family-Based Treatment (FBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cefdinir for Oral Suspension 250 mg/5mL, Non-fasting
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cefdinir for oral suspension 250 mg/5mL|DRUG: OMNICEF® for oral suspension 250 mg/5mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Linagliptin as Add on Therapy to Empagliflozin 10 mg or 25 mg With Background Metformin in Patient With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: BI 10773|DRUG: BI 10773 Placebo|DRUG: BI 10773 / BI 1356|DRUG: BI 10773|DRUG: BI 10773 / BI 1356|DRUG: BI 10773 / BI 1356 Placebo|DRUG: BI 10773|DRUG: BI 10773|DRUG: BI 10773|DRUG: BI 10773 / BI 1356 Placebo|DRUG: BI 10773 Placebo|DRUG: BI 10773 / BI 1356 Placebo|DRUG: BI 10773|DRUG: BI 10773 / BI 1356 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Trial to Determine the Maximum Tolerated Dose (MTD) Based on Safety and Tolerability, of Org 26576 in Participants With Major Depressive Disorder (174001/P05704/MK-8777-001)
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: MK-8777|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EASYX-1 : A Multicenter Study on Safety and Efficacy of Easyx Liquid Embolization Agent Used in Five Separate Indications
Status: COMPLETED
Conditions: Varicocele|Endoleak|Portal Vein Thrombosis|Bleeding|Angiomyolipoma
Interventions: DEVICE: Easyx
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eliminating the Need for Pancreas Biopsy Using Peripheral Blood Cell-free DNA
Status: ACTIVE_NOT_RECRUITING
Conditions: Transplant;Failure,Kidney|Transplant; Failure, Pancreas|Rejection Acute Renal|Rejection Acute Pancreas
Interventions: DIAGNOSTIC_TEST: dd-cfDNA Blood Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of a Behavioural Intervention on Injury Prevention Program Adherence in Female Youth Soccer
Status: COMPLETED
Conditions: Sport Injury
Interventions: BEHAVIORAL: HAPA-based coach education workshop|BEHAVIORAL: placebo attention control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Multi-device Testing for Autonomic Nervous System Stimulation
Status: COMPLETED
Conditions: Vagus Nerve Stimulation
Interventions: OTHER: Manual Head Massage|DEVICE: BREO Helmet Massager|DEVICE: Low Laser Therapy (LLT)|DEVICE: Sham LLT|DEVICE: TENS ear stimulation|BEHAVIORAL: Deep and Slow breathing|BEHAVIORAL: Relaxed Reading time
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extended VALidation of HUman Papillomavirus Assays and Collection DEvices for HPV Testing on Self-samples
Status: UNKNOWN
Conditions: Cervical Intraepithelial Neoplasia Grade 2/3|Carcinoma Cervix
Interventions: DIAGNOSTIC_TEST: BD Onclarity™ HPV assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of Real-time Fluorescence Imaging in Diabetic Foot Ulcers: the Impact of Colonization
Status: ACTIVE_NOT_RECRUITING
Conditions: Infection, Surgical Site
Interventions: DEVICE: MolecuLight
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability And Pharmacokinetics Study Of Single Doses Of PNU-100480 In Healthy Adults
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: PNU-100480|DRUG: PNU-100480|DRUG: Placebo|DRUG: PNU-100480|DRUG: PNU-100480|DRUG: Placebo|DRUG: PNU-100480|DRUG: PNU-100480|DRUG: Placebo|DRUG: PNU-100480|DRUG: PNU-100480|DRUG: PNU-100480|DRUG: Placebo|DRUG: PNU-100480|DRUG: PNU-100480|DRUG: PNU-100480|DRUG: Placebo|DRUG: PNU-100480|DRUG: PNU-100480|DRUG: PNU-100480|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Effectiveness of Recovery Protocols in Elite Professional Young Soccer Players
Status: COMPLETED
Conditions: Soccer|Physical Stress|Fatigue
Interventions: OTHER: Powerade©, CHP, CJ, FR, CWI|OTHER: Powerade©, CHP, STR, ICWI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparing the Current Hydration Regimen for the ABC02 Chemotherapy Regimen Versus a Shorter Hydration
Status: UNKNOWN
Conditions: Gallbladder Cancer
Interventions: COMBINATION_PRODUCT: Shortened hydration time and dispensary of Akynzeo|COMBINATION_PRODUCT: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dose Escalation Study of Safety and Tolerability of AT-406 in Patients With Advanced Solid Tumors and Lymphomas
Status: COMPLETED
Conditions: Cancer|Solid Tumors|Lymphoma|Malignancy
Interventions: DRUG: Debio 1143 (AT-406)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rucaparib and Pembrolizumab for Maintenance Therapy in Stage IV Non-Squamous Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage IV Non-small Cell Lung Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Pemetrexed|DRUG: Carboplatin|DRUG: Rucaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone in the Prevention of Post-spinal Paralytic Ileus After Cesarean Section
Status: RECRUITING
Conditions: Postoperative Ileus
Interventions: DRUG: 0.9%sodium chloride|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: W-Shaped Acetabular Angular Plate (WAAP) Versus Reconstruction Plate
Status: UNKNOWN
Conditions: Fracture of Posterior Wall of Acetabulum
Interventions: DEVICE: W-Shaped Angular Plate|DEVICE: Reconstruction Plate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Renuvion APR System When Used as an Adjunct Procedure In Gynecomastia Surgery
Status: COMPLETED
Conditions: Gynecomastia
Interventions: DEVICE: Renuvion APR System|PROCEDURE: Gynecomastia Correction Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cell Signaling, Reinnervation and Metabolism in Kennedy Disease and Amyotrophic Lateral Sclerosis (ALS)
Status: RECRUITING
Conditions: Amyotrophic Lateral Sclerosis|Kennedy Disease
Interventions: PROCEDURE: Muscle biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Adaptive Arm Training for Children With Hemiplegia
Status: UNKNOWN
Conditions: Cerebral Palsy|Hemiplegia|Hemiparesis|Acquired Brain Injury
Interventions: DEVICE: Bimanual Arm Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Preliminary Efficacy of ATG-017 Monotherapy or Combination Therapy With Nivolumab in Advanced Solid Tumors and Hematological Malignancies
Status: TERMINATED
Conditions: Solid Tumor|Hematological Malignancy
Interventions: DRUG: ATG-017|DRUG: ATG-017+Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The CLASP Study Edwards PASCAL TrAnScatheter Mitral Valve RePair System Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Mitral Valve Regurgitation
Interventions: DEVICE: Mitral Valve Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Age-related Conditions in the Context of Multimorbidity and Frailty: Relative Weight of Frailty in Determining the Course and Outcomes of Different Chronic Diseases and Viceversa
Status: NOT_YET_RECRUITING
Conditions: Frailty|Sarcopenia
Interventions: DIAGNOSTIC_TEST: completion of scales and questionnaires; venous blood sampling; muscle ultrasound; cardiac ultrasound; electrocardiogram; bioelectrical impedance analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Efficacy of NTU 101 Lactic Acid Bacteria Powder in the Adjuvant Improvement of Atopic Dermatitis Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Atopic Dermatitis|Atopic Dermatitis Eczema
Interventions: DIETARY_SUPPLEMENT: Lactic acid bacteria NTU 101|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Breathing and Attention in Children With Ondine Syndrome
Status: RECRUITING
Conditions: Ondine Syndrome|Congenital Central Hypoventilation Syndrome (CCHS)
Interventions: OTHER: neuropsychological tests used usually in clinical practice (TEA-ch, NEPSY, BRIEF) and research (Conners 3, K-CPT II or CPT III, Flankers Task)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of a Probiotic to Treat Gingivitis in Pediatric Patients
Status: COMPLETED
Conditions: Gingivitis|Inflammation
Interventions: DIETARY_SUPPLEMENT: Probiotic formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subclinical Transthyretin Cardiac Amyloidosis in V122I TTR Carriers
Status: RECRUITING
Conditions: Amyloidosis, Hereditary|Amyloidosis Cardiac|Amyloidosis, Familial|Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy|Transthyretin Gene Mutation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Extended Pancreatic Transection Versus Conventional Pancreatic Transection During Laparoscopic Pancreaticoduodenectomy
Status: NOT_YET_RECRUITING
Conditions: Laparoscopic Pancreaticoduodenectomy
Interventions: PROCEDURE: extended pancreatic transection during laparoscopic pancreaticoduodenectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of Telerehabilitation on Muscle Function, Physical Activity and Sleep in Cystic Fibrosis During Pandemic
Status: COMPLETED
Conditions: Cystic Fibrosis|Covid19|Social Isolation
Interventions: OTHER: Telerehabilitation-based|OTHER: Follow-up based
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study to Evaluate Safety and Anti-tumor Activity of PB101, an Anti-angiogenic Immunomodulating Agent
Status: RECRUITING
Conditions: Solid Tumor, Adult|Solid Tumor|Gastric Cancer|Hepatocellular Carcinoma|Metastatic Colorectal Cancer|Advanced Solid Tumor
Interventions: DRUG: PB101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Examine Individual Pain Tolerance in the Use of Two Anesthetic Techniques to Perform Saturation Prostate Biopsy
Status: COMPLETED
Conditions: Prostatic Cancer
Interventions: DRUG: MIDAZOLAM|DRUG: MEPIVACAÍNE|DRUG: FENTANILE|DRUG: KETAMINE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dynamic Balance in Unilateral Transtibial Amputees Following Virtual Reality Versus Conventional Rehabilitation
Status: NOT_YET_RECRUITING
Conditions: Amputees / Rehabilitation|Virtual Reality|Postural Balance
Interventions: OTHER: Virtual Reality|OTHER: Standard rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of Intravenous Thrombolysis in Patients With Ischemic Stroke and Direct Oral Anticoagulants Intake
Status: NOT_YET_RECRUITING
Conditions: Ischemic Stroke
Interventions: DRUG: Tenecteplase or Alteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of Weight-Based Versus Standard Dose Enoxaparin Thromboprophylaxis In High-Risk Hospitalized Cancer Patients
Status: COMPLETED
Conditions: Venous Thormboembolism
Interventions: DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: N-Force Screws Augmented With N-Force Blue in Hip Fractures
Status: TERMINATED
Conditions: Intracapsular Proximal Femur Fracture|Garden Grade I Subcapital Fracture of Femoral Neck|Garden Grade II Subcapital Fracture of Femoral Neck
Interventions: DEVICE: N-Force Screws Augmented with N-Force Blue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccination Response in Tecfidera-Treated Versus Interferon-Treated Participants With Relapsing Forms of Multiple Sclerosis.
Status: COMPLETED
Conditions: Relapsing Forms of Multiple Sclerosis
Interventions: DRUG: dimethyl fumarate|BIOLOGICAL: tetanus diphtheria toxoids vaccine|BIOLOGICAL: 23-valent pneumococcal polysaccharide vaccine|BIOLOGICAL: meningococcal polysaccharide diphtheria conjugate vaccine (quadrivalent)|DRUG: non-pegylated interferon
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chitosan Scaffold for Sellar Floor Repair in Endoscopic Endonasal Transsphenoidal Surgery
Status: COMPLETED
Conditions: Csf Leakage
Interventions: OTHER: Implant of bilaminar chitosan scaffold
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of Once Daily Administration of Atrasentan Tablets (Low and High) Compared to Placebo in Reducing Residual Albuminuria in Type 2 Diabetic Patients With Nephropathy Who Are Treated With the Maximum Tolerated Labeled Dose of a Renin Angiotensin System (RAS) Inhibitor
Status: COMPLETED
Conditions: Chronic Kidney Disease|Diabetic Nephropathy
Interventions: DRUG: Atrasentan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Neuroprotective Strategy for Ischemic Stroke With Sufficient Recanalization After Thrombectomy by Intra-arterial Cocktail Therapy (INSIST-CT)
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: intra-arterial cocktail therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ADVAIR DISKUS® (Fluticasone Propionate/Salmeterol) Inhaler Versus SEREVENT DISKUS® (Salmeterol) Inhlaer On Inflammatory Cells And Markers In Chronic Obstructive Pulmonary Disease. ADVAIR DISKUS® and SEREVENT DISKUS® Inhalers Are Trademarks of the GSK Group of Companies.
Status: TERMINATED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Salmeterol|DRUG: Fluticasone Propionate/Salmeterol Combination Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Atomoxetine and Huntington's Disease
Status: COMPLETED
Conditions: Huntington Disease|Chorea
Interventions: DRUG: atomoxetine|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ESN364 in Healthy Japanese Male and Pre- and Post-menopausal Female Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: ESN364|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial Investigating the Safety and Effects of One BNT162 Vaccine Against COVID-19 in Healthy Adults
Status: COMPLETED
Conditions: Covid-19|Protection Against COVID-19
Interventions: BIOLOGICAL: BNT162b3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Angioplasty to Blunt the Rise of Troponin in Acute Coronary Syndrome (ACS)
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: PROCEDURE: Catheterization immediate PCI|PROCEDURE: delayed PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GNRH Agonist Trigger and Modified Luteal Phase Adding a Bolus of GnRHa at the Time of Implantation: a RCT
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Triptorelin 0.1 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Covers to Improve Esthetic Outcome After Surgery for Chronic Subdural Hematoma
Status: COMPLETED
Conditions: Hematoma, Subdural, Chronic|Hematoma, Subdural, Intracranial|Haematoma;Subdural;Traumatic
Interventions: DEVICE: Placement of burr-hole covers|OTHER: No placement of burr-hole covers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: NOVA22007 0.05% and 0.1% Cyclosporine Versus Vehicle for the Treatment of Dry Eye
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: NOVA22007 ''Cyclosporine''|DRUG: NOVA22007 ''Cyclosporine''|DRUG: vehicle/placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Hemostatic Patch to Fibrin Sealant (TachoSil®) in Subjects Undergoing Hepatic Surgery
Status: COMPLETED
Conditions: Liver Disease
Interventions: DEVICE: Veriset Hemostatic Patch|DEVICE: Fibrin Sealant (TachoSil®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Trans Women Connected Mobile App for Changes in Sexual Health-related Behavior Among Transgender Women
Status: COMPLETED
Conditions: HIV/AIDS|Health Knowledge, Attitudes, Practice|STI
Interventions: BEHAVIORAL: Trans Women Connected|BEHAVIORAL: General Health App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety,PK and PD of APG-2575 in Patients With Hematologic Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Non Hodgkin Lymphoma
Interventions: DRUG: APG-2575
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Peanut Balls Used of the Second Stage of Labor, Pushing Perceptions, Fatigue and Birth Outcomes
Status: COMPLETED
Conditions: Other
Interventions: OTHER: The side-lying position with the peanut ball during the second stage of labor.|OTHER: During the second stage, the patient is placed in a lateral position
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized Open Label Phase II Study to Evaluate the Efficacy of Enzalutamide in High Risk Male Outpatients With COVID-1
Status: TERMINATED
Conditions: COVID-19 Infection
Interventions: DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effects of Anticoagulant Interruption Covered by Percutaneous Left Atrial Occlusion in Patients With Chronic Atrial Fibrillation and Radiation Cystitis at Risk of Bleeding
Status: RECRUITING
Conditions: Radiation Cystitis|Non-valvular Atrial Fibrillation
Interventions: DEVICE: Percutaneous left atrial closure|OTHER: No Percutaneous left atrial closure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect-site Concentration of Remifentanil for Preventing Cough During Emergence From Balanced Anesthesia for Nasal Surgery
Status: COMPLETED
Conditions: Cough
Interventions: DRUG: Dixon up-and-down method
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metacognitive Therapy for Obsessive-Compulsive Disorder
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder (OCD)
Interventions: BEHAVIORAL: Metacognitive Therapy|BEHAVIORAL: Exposure and Response Prevention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Escitalopram Treatment of Night Eating Syndrome
Status: COMPLETED
Conditions: Night Eating Syndrome
Interventions: DRUG: Escitalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Efficacy and Safety of Inhaled Interferon-β Therapy for COVID-19
Status: COMPLETED
Conditions: Severe Acute Respiratory Syndrome Coronavirus 2|COVID-19
Interventions: DRUG: SNG001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improvement of Diabetic Foot Care in Salamanca Through the Implementation of Standardized Protocols.
Status: COMPLETED
Conditions: Primary Health Care|Diabetes|Diabetic Foot
Interventions: OTHER: Diabetic foot care protocol|OTHER: Group education sessions for patients and/or caregivers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of Pain Relief in Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: DRUG: Extended release hydrocodone and acetaminophen (Vicodin CR)|DRUG: hydrocodone/acetaminophen extended release (Vicodin CR)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Comparing Safety and Reactogenicity, of Lyophilized BCG Vaccine IP of Green Signal Bio Pharma Private Limited, India With BCG Vaccine of Serum Institute of India Limited in 120 Healthy Children.
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: BCG Vaccine IP - Serum Institute of India
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Plazomicin Compared With Levofloxacin for the Treatment of Complicated Urinary Tract Infection (cUTI) and Acute Pyelonephritis (AP)
Status: COMPLETED
Conditions: Complicated Urinary Tract Infection|Acute Pyelonephritis
Interventions: DRUG: levofloxacin|DRUG: plazomicin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First-in-Human Study of RLY-5836 in Advanced Breast Cancer and Other Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: PIK3CA Mutation|Solid Tumor, Adult|HER2-negative Breast Cancer|Breast Cancer|Metastatic Breast Cancer|Advanced Breast Cancer|Unresectable Solid Tumor|Hormone Receptor Positive Tumor
Interventions: DRUG: RLY-5836|DRUG: Fulvestrant|DRUG: Palbociclib|DRUG: Ribociclib|DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Homeopathic Treatment of Post-acute COVID-19 Syndrome
Status: COMPLETED
Conditions: Post-acute Covid-19 Syndrome
Interventions: DRUG: Homeopathic Medication|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Subcutaneous Isatuximab in Combination With Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed/Refractory Multiple Myeloma
Interventions: DRUG: Isatuximab|DRUG: Carfilzomib|DRUG: Dexamethasone|DRUG: Dexamethasone IV|DRUG: Montelukast|DRUG: Acetaminophen|DRUG: Diphenhydramine|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effectiveness and Safety of Risperidone as add-on Therapy to Mood Stabilizers in the Treatment of Manic Episodes Associated With Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorders|Manic Disorder
Interventions: DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Antibacterial Effect of Nanosilver Fluoride on Primary Teeth
Status: TERMINATED
Conditions: Primary Teeth|Microbial Colonization|Caries|Dental Caries in Children
Interventions: DRUG: Nanosilver Fluoride (NSF)|DRUG: Silver diamine fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of OMEGAVEN 10%® (n-3 EFA Lipid Emulsion) in Home Parenteral Nutrition-associated Liver Disease
Status: COMPLETED
Conditions: Liver Diseases
Interventions: DRUG: Intralipid 20%®|DRUG: OMEGAVEN 10%®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study of VX-659 Combination Therapy in Subjects With Cystic Fibrosis Heterozygous for the F508del Mutation and a Minimal Function Mutation (F/MF)
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: VX-659/TEZ/IVA|DRUG: IVA|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety, Tolerability & Efficacy of CK-2017357 in Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: CK-2017357|OTHER: Placebo tablets|DRUG: Riluzole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Controlled Study of the Effect of Xenaderm® Ointment Vehicle Versus White Petrolatum on Healing
Status: COMPLETED
Conditions: Wounds
Interventions: DRUG: Xenaderm Vehicle|OTHER: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Plus Interleukin-2 in Treating Patients With Advanced Melanoma
Status: COMPLETED
Conditions: Recurrent Melanoma|Stage IV Melanoma
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: gp100:209-217(210M) peptide vaccine|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Efficacy of Pitavastatin With That of Atorvastatin in Lowering Cholesterol Levels
Status: COMPLETED
Conditions: Primary Hypercholesterolemia|Dyslipidemia
Interventions: DRUG: Pitavastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Accuracy of Surgical Guide Designed From Dental Model Optical Scan Versus Impression Inversion With Markers Techniques in Computer Guided Implantology. Randomized Clinical Trial.
Status: UNKNOWN
Conditions: Accuracy of Surgical Guide in Computer Guided Implantology
Interventions: OTHER: Surgical guide designed from Impression inversion with markers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Treatment With Probiotics (Saccharomyces Boulardii) and Its Role in Bacterial Translocation and Immune Reconstitution in VIH Infection.
Status: UNKNOWN
Conditions: HIV -1 Infection
Interventions: DIETARY_SUPPLEMENT: Probiotic.|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calisthenic and Neuromuscular Training in Patients With Knee OA.
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Calisthenic Training|OTHER: Neuromuscular Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non Invasive Brain Stimulation Effects on Attentional Performance in ADHD Adults
Status: COMPLETED
Conditions: Attention Deficit/Hyperactivity Disorder
Interventions: DEVICE: Transcranial magnetic stimulation (Neurosoft®)|DEVICE: Transcranial direct current stimulation (Soterix, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Exposure to an Informative Video About Amniocentesis Before the Procedure on Maternal Anxiety
Status: COMPLETED
Conditions: Pregnancy Related|Anxiety in Pregnancy|Amniocentesis Affecting Fetus or Newborn
Interventions: OTHER: Informative video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Percutaneous Temporary Placement of a Phrenic Nerve Stimulator for Diaphragm Pacing (RESCUE1)
Status: COMPLETED
Conditions: Ventilator Induced Diaphragm Dysfunction
Interventions: DEVICE: Lungpacer DPTS (Diaphragm Pacing Therapy System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: pCLE in the Detection of Esophageal and Gastric Lesions and Intestinal Metaplasia or Dysplasia in Patients After Endoscopic Treatment of BORN
Status: COMPLETED
Conditions: Barrett's Esophagus
Interventions: OTHER: Biopsies with histopathology
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Enriched Environments in Endometriosis
Status: COMPLETED
Conditions: Endometriosis-related Pain|Endometriosis|Pelvic Pain|Quality of Life|Inflammation Pelvic
Interventions: BEHAVIORAL: Environmental enrichment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on the Effect of Brucea Javanica Oil Emulsion Injection on the Survival of Patients With Advanced Colorectal Cancer Who Failed to Receive Multi-line Treatment
Status: RECRUITING
Conditions: Colorectal Cancer|Chinese Herbal Medicine|Progression-free Survival|Quality of Life
Interventions: OTHER: Brucea javanica oil emulsion injection|OTHER: The best supportive treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Determine the Maximum Tolerated Dose (MTD) of HK-001 in Healthy Volunteers
Status: ACTIVE_NOT_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: HK-001|DRUG: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence of Acute Urine Retention: Randomized Clinical Trial Comparing Early, Mid or Late Urinary Catheter Removal in Patients With Rectal Resection
Status: UNKNOWN
Conditions: Rectal Cancer|Retention, Urinary|Urinary Tract Infections|Surgical Site Infection|Anastomotic Leak
Interventions: PROCEDURE: Removal of Urinary Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy Study of CYT997 in Combination With Carboplatin in Glioblastoma
Status: TERMINATED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: CYT997|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT