pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Robotic Assisted Laparoscopic Prostatectomy With or Without Pelvic Drain Placement in Reducing Adverse Events After Surgery in Patients With Prostate Cancer
Status: COMPLETED
Conditions: Perioperative/Postoperative Complications|Prostate Cancer
Interventions: PROCEDURE: robot-assisted laparoscopic surgery|OTHER: questionnaire administration|OTHER: intraoperative complication management/prevention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Azilsartan in Subjects With Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Azilsartan|DRUG: Azilsartan|DRUG: Azilsartan|DRUG: Azilsartan|DRUG: Azilsartan|DRUG: Placebo|DRUG: Olmesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sorafenib, Gemcitabine, and Capecitabine in Treating Patients With Unresectable and/or Metastatic Kidney Cancer
Status: COMPLETED
Conditions: Recurrent Renal Cell Carcinoma|Stage III Renal Cell Cancer AJCC v7|Stage IV Renal Cell Cancer AJCC v7
Interventions: DRUG: Capecitabine|DRUG: Gemcitabine Hydrochloride|DRUG: Sorafenib Tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of a Novel Integrated Care Concept (NICC) for Patients Suffering From Chronic Cardiovascular Disease
Status: UNKNOWN
Conditions: Heart Failure|Atrial Fibrillation|Treatment Resistant Hypertension
Interventions: OTHER: Novel integrated care concept (NICC)|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of PM1021 (Anti-TIGIT) With or Without PM8001 (Anti-PD-L1/TGF-β) in Patients With Advanced Solid Tumours
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumours
Interventions: DRUG: PM1021, PM8001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety, Tolerability, and Pharmacokinetics of REGN3470-3471-3479 in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: REGN3470-3471-3479|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Point-of-care Pharmacogenomic Testing to Optimize Isoniazid Dosing for Tuberculosis Prevention
Status: RECRUITING
Conditions: Tuberculosis Infection|Isoniazid Adverse Reaction
Interventions: DRUG: Low-dose isoniazid|DRUG: Standard dose of isoniazid|DRUG: High-dose isoniazid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Suicidal Women With Borderline Personality Disorder
Status: COMPLETED
Conditions: Borderline Personality Disorder|Suicide
Interventions: BEHAVIORAL: Standard dialectical behavior therapy (SDBT)|BEHAVIORAL: Individual DBT with no DBT group sessions (DBT-I)|BEHAVIORAL: Group Skills DBT with no DBT individual sessions (DBT-S)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Myofascial Release or Trigger Point Injections for the Reduction of Post-Mastectomy Pain Syndrome
Status: WITHDRAWN
Conditions: Breast Carcinoma
Interventions: PROCEDURE: Acupuncture Point Injection|PROCEDURE: Massage Therapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment
Status: RECRUITING
Conditions: Polycystic Ovary Syndrome
Interventions: DIETARY_SUPPLEMENT: Inositol + alpha lipoic acid|DIETARY_SUPPLEMENT: Inositol|DIETARY_SUPPLEMENT: Folic acid (placebo comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Comparison of the Efficacy of Gingival Unit Graft With Connective Tissue Graft in Root Coverage
Status: COMPLETED
Conditions: Gingival Recession|Periodontal Diseases
Interventions: PROCEDURE: Root coverage treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety and Efficacy of LT-02 in Patients With Mesalamine Refractory Ulcerative Colitis (UC)
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: DRUG: LT-02|DRUG: LT-02 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multinational, Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy, Pharmacodynamics, Pharmacokinetics, and Safety of Venglustat in Late-onset GM2
Status: ACTIVE_NOT_RECRUITING
Conditions: Tay-Sachs Disease|Sandhoff Disease
Interventions: DRUG: venglustat GZ402671|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With HER2-Negative Stage III-IV Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: HER2 Negative Breast Carcinoma|Recurrent Breast Carcinoma|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer|Stage III Breast Cancer
Interventions: BIOLOGICAL: CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ability of Metoprolol to Alter the Exercise Induced Elevation of Catecholamines
Status: UNKNOWN
Conditions: Heart Failure
Interventions: DRUG: Metoprolole (Selo-Zok ®)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Ovarian Follicular Dynamics and Emergency Contraception
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: 0.75 levonorgestrel|DRUG: 50 mg ethinyl estradiol/0.5 mg levonorgestrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Rapid Titration Protocols of Lacosamide
Status: COMPLETED
Conditions: Focal Epilepsy
Interventions: DRUG: Lacosamide - conventional titration|DRUG: Lacosamide - rapid titration 1|DRUG: Lacosamide - rapid titration 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Treprostinil Palmitil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Effect of NdYag Laser for the Treatment of Hidradenitis Suppurativa
Status: COMPLETED
Conditions: Hidradenitis Suppurativa
Interventions: PROCEDURE: Long-pulsed Nd:YAG laser 1064 nm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: HFHS-1801-A Pilot Study of Immunotherapy as Consolidation Therapy for Patients With Recurrent Head and Neck Cancer
Status: RECRUITING
Conditions: Head and Neck Neoplasms
Interventions: DRUG: Pembrolizumab 25 MG/1 ML Intravenous Solution [KEYTRUDA]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Inactivated, Split-Virion Influenza Vaccine Administered by Intradermal Route Versus Vaxigrip® in Adults
Status: COMPLETED
Conditions: Influenza|Orthomyxoviridae Infection|Myxovirus Infection
Interventions: BIOLOGICAL: Inactivated, split-virion influenza vaccine|BIOLOGICAL: Inactivated, split-virion influenza vaccine|BIOLOGICAL: Inactivated, split-virion influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Conventional Physical Therapy With and Without Cuevas Medek Exercises in Developmental Delay
Status: RECRUITING
Conditions: Motor Delay
Interventions: OTHER: conventional physical therapy|OTHER: Conventional physical therapy along with cuevas medek exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Study Evaluating AZR-MD-001 in Patients With Meibomian Gland Dysfunction and Evaporative Dry Eye Disease (DED)
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction|Dry Eye
Interventions: DRUG: AZR-MD-001 Low Dose|DRUG: AZR-MD-001 Mid Dose|DRUG: AZR-MD-001 High Dose|DRUG: AZR-MD-001 Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Staying Strong With Schools - A School-Based Resilience Support Intervention for Military-Connected Children
Status: COMPLETED
Conditions: Staying Strong With Schools Intervention|Waitlist Control
Interventions: BEHAVIORAL: Staying Strong with Schools Intervention|OTHER: Waitlist Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Epidemic Profile of Left Ventricular Diastoic Dysfunction in the Community Elderly and Establishing Prediction Model: the Northern Shanghai Study
Status: COMPLETED
Conditions: Left Ventricular Diastoic Dysfunction Cohort Study
Interventions: OTHER: Diuretic，Betaloc，antiplatelet drugs
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nutritional Parameters and Other Risk Factors Affecting Severity of Pneumonia in Children Under Five Years in Upper Egypt
Status: UNKNOWN
Conditions: Hypoalbuminemia|Stunted Growth|Anemia, Iron Deficiency
Interventions: DIETARY_SUPPLEMENT: Measurement of nutritional parameters in children with pneumonia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Muscadine Grape Extract to Improve Fatigue
Status: RECRUITING
Conditions: Fatigue
Interventions: DIETARY_SUPPLEMENT: Muscadine grape extract|DRUG: Placebo|OTHER: Quality of Life Assessment|OTHER: Questionnaires|OTHER: Participant Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Use of Drospirenone/Estetrol, Nomegestrol Acetate/Estradiol and Ethinylestradiol/Dienogest in Random Start Rapid Endometrial Preparation
Status: COMPLETED
Conditions: Endometrial Polyp|Endometrial Diseases
Interventions: DRUG: Drospirenone / Estetrol|DRUG: Nomegestrol Acetate / Estradiol|DRUG: Ethinylestradiol / Dienogest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib Study of Intravenous Copper Loading With Oral Disulfiram in Metastatic, Castration Resistant Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Copper|DRUG: Disulfiram|DRUG: Copper gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Travoprost 0.004%/Timolol 0.5% Versus Latanoprost 0.005%/Timolol in Chinese Patients With Open-Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Travoprost 0.004%/Timolol 0.5%|DRUG: Latanoprost 0.005% / Timolol 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Paracervical Block Volume on Pain Control for Dilation and Curettage.o
Status: COMPLETED
Conditions: Abortion, Spontaneous|Abortion in First Trimester|Pain Uterus|Abortion Early|Abortion, Missed
Interventions: DRUG: 40cc buffered 0.5% lidocaine with 2 units of vasopressin paracervical block|DRUG: 20cc 1% lidocaine with 2 units of vasopressin paracervical block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ustekinumab in Patients With Palmo-Plantar Pustular Psoriasis or With Palmo-Plantar Pustulosis
Status: TERMINATED
Conditions: Palmo-Plantar Pustular Psoriasis|Palmo-Plantar Pustulosis
Interventions: DRUG: Ustekinumab|DRUG: Placebo (Soduim Chloride)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Certolizumab Pegol as Additional Therapy in Chinese Patients With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Certolizumab Pegol|DRUG: Methotrexate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RESOLUTE ONYX China RCT Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Ischemic Heart Disease|Stenotic Coronary Lesion|Cardiovascular Diseases|Arteriosclerosis|Coronary Artery Disease
Interventions: DEVICE: Resolute Onyx™ Zotarolimus-Eluting Coronary Stent System|DEVICE: Resolute Integrity™ Zotarolimus-Eluting Coronary Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promotion of Exclusive Breast Feeding and Young Child Feeding Practices Through m-Health
Status: NOT_YET_RECRUITING
Conditions: Malnutrition, Infant|Malnutrition, Child
Interventions: BEHAVIORAL: First diet: m-health coaching application|BEHAVIORAL: Face to Face counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Upper Eyelid Surgeries on Corneal Characteristics
Status: RECRUITING
Conditions: Eyelid Diseases|Ptosis, Eyelid
Interventions: PROCEDURE: levator muscle resection surgery|PROCEDURE: Müller's muscle-conjuctival resection surgery|PROCEDURE: full-thickness anterior blepharotomy surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Non-anesthesiologist-administered Propofol During the Flexible Bronchoscopy
Status: COMPLETED
Conditions: Conscious Sedation Failure During Procedure
Interventions: DEVICE: Transcutaneous CO2 monitor|DRUG: Midazolam|DRUG: Propofol|DRUG: Nalbuphine|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Intra-arterial Alteplase for Acute Ischemic Stroke After Mechanical Thrombectomy
Status: RECRUITING
Conditions: Stroke, Acute Ischemic
Interventions: DRUG: Alteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Auricular Acupuncture vs. Progressive Muscle Relaxation in Patients With Anxiety Disorders or Major Depressive Disorder.
Status: COMPLETED
Conditions: Anxiety Disorders|Depressive Disorder, Major
Interventions: DEVICE: Auricular acupuncture|PROCEDURE: Progressive muscle relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pneumonia Vaccine in Aging HIV Positive Individuals
Status: COMPLETED
Conditions: Pneumococcal Infection
Interventions: BIOLOGICAL: 23-valent pneumococcal polysaccharide vaccine|BIOLOGICAL: 13-valent pneumococcal conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Using Explainable AI Risk Predictions to Nudge Influenza Vaccine Uptake
Status: COMPLETED
Conditions: Influenza|Vaccination|Health Promotion|Health Behavior|Risk Reduction
Interventions: BEHAVIORAL: Reminder|BEHAVIORAL: Risk reduction|BEHAVIORAL: Medical records-based recommendation|BEHAVIORAL: Algorithm-based recommendation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Clinical Effects of Diquas-S for Patients With Dry Eye After Cataract Surgery
Status: COMPLETED
Conditions: Dry Eye|Cataract Surgery
Interventions: DRUG: 1. Use of preservative free diquafosol ophthalmic solution after cataract surgery|DRUG: 2. Use of preservative containing diquafosol ophthalmic solution after cataract surgery|DRUG: 3. Use of preservative free sodium hyaluronate ophthalmic solution after cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ProTmune for Allogeneic HCT in Adult Patients With Hematologic Malignancies
Status: COMPLETED
Conditions: Hematologic Malignancies|Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Myelodysplastic Syndromes|Chronic Myelogenous Leukemia|Acute Graft-versus-host Disease
Interventions: BIOLOGICAL: ProTmune|BIOLOGICAL: Control Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Randomized Trial Comparing Efficacy of Adalimumab, Anakinra and Tocilizumab in Non-infectious Refractory Uveitis
Status: COMPLETED
Conditions: Uveitis|Biotherapy
Interventions: DRUG: Anakinra|DRUG: Tocilizumab|DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parent-Level Predictors of Early Language Interaction Quality and Intervention Outcomes
Status: RECRUITING
Conditions: Language Development Disorders|Autism Spectrum Disorder
Interventions: BEHAVIORAL: Enhanced Milieu Teaching|OTHER: no intervention comparison group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Effectiveness and Adverse Effects of Cervical Manipulation, Mobilisation and the Activator Instrument in Patients With Sub-acute Non-specific Neck Pain: a Pragmatic Randomised Trial
Status: COMPLETED
Conditions: Neck Pain
Interventions: PROCEDURE: manipulation|PROCEDURE: Mobilisation|DEVICE: Activator instrument
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metabolic and Appetite Parameters Following Addition of Whey Protein to a Fat-based Breakfast
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Whey Protein|OTHER: High Fat Breakfast Meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Relapse Predicting Model for First Episode Depression
Status: UNKNOWN
Conditions: Major Depressive Disorders
Interventions: OTHER: Clinical features and medication|OTHER: Psycho-social|OTHER: immunology|OTHER: Laboratory abnormality|OTHER: Comorbidity|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Amplatzer Amulet and Watchman Device in Patients Undergoing Left Atrial Appendage Closure. (SWISS-APERO)
Status: ACTIVE_NOT_RECRUITING
Conditions: Left Atrial Appendage Closure
Interventions: DEVICE: Amplatzer Amulet for left atrial appendage closure|DEVICE: Watchman/FLX for left atrial appendage closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety, Tolerability, and Efficacy of Topical SM04554 Solution in Male Subjects With Androgenetic Alopecia (AGA)
Status: COMPLETED
Conditions: Androgenetic Alopecia
Interventions: DRUG: SM04554|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of a Smartphone Based Self Refraction Tool With Conventional Refraction Error Estimation Methods
Status: UNKNOWN
Conditions: Refractive Errors|Self-Examination
Interventions: DIAGNOSTIC_TEST: Smartphone|DIAGNOSTIC_TEST: Autorefractor|DIAGNOSTIC_TEST: Individual
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Value of Adding Either Meperdine or Fentanyl to Clonidine-bupivacaine
Status: COMPLETED
Conditions: Amputation Stumps
Interventions: DRUG: Meperdine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Transcutaneous Supraorbital Nerve Stimulator Versus Topiramate in Prevention of Recurrent Migraine
Status: UNKNOWN
Conditions: Migraine, Classic
Interventions: DEVICE: Transcutaneous Supraorbital Nerve Stimulator|DRUG: Topiramate 25Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study of Intravenously Administered BMS-986168 in Healthy Subjects
Status: COMPLETED
Conditions: Tauopathies
Interventions: DRUG: BMS-986168|DRUG: BMS-986168 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 12-Week, Phase 2 Study of Gemcabene in Hypercholesterolemia Patients on Stable Moderate and High-Intensity Statins
Status: COMPLETED
Conditions: Hypercholesteremia
Interventions: DRUG: Gemcabene|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraperitoneal and Intravenous Paclitaxel Chemotherapy With Oral Capecitabine for Gastric Adenocarcinoma With Peritoneal Carcinomatosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Adenocarcinoma|Gastric Cancer|Esophagogastric Junction|Peritoneal Carcinomatosis
Interventions: DRUG: Paclitaxel|DRUG: Capecitabine|DEVICE: BardPort Titanium Implanted Port with Peritoneal Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TCR Alpha/Beta Depletion for HSCT From Haploidentical and Unrelated Donors in the Treatment of PID
Status: COMPLETED
Conditions: Primary Immune Deficiency Disorder|Hematopoietic Stem Cell Transplantation
Interventions: OTHER: Biological: TCR alfa beta T cell depletion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Exposure to SGLT2 Inhibitors and Post-operative Acute Renal Failure in Cardiac Surgery
Status: COMPLETED
Conditions: Acute Kidney Injury|Cardiac Surgery|Sodium/Glucose Cotransporter Inhibitor 2
Interventions: OTHER: Post Operative Acute Kidney Injury
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mindfulness Meditation as a Rehabilitation Strategy for Persons With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Psychotic Disorders
Interventions: BEHAVIORAL: Mindfulness Meditation|BEHAVIORAL: Support Group (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Trans Venous Cardiac Pacing on Coronary Microvascular Function and Hemodynamics
Status: WITHDRAWN
Conditions: Coronary Microvascular Disease|Cardiac Pacemaker Syndrome
Interventions: DIAGNOSTIC_TEST: Coronary flow and pressure measurement in patients with ventricular pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interleukin-12 Followed by Interferon Alfa in Treating Patients With Advanced Cancer
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Precancerous Condition|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: recombinant interferon alfa|BIOLOGICAL: recombinant interleukin-12
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developmental Dysplasia of the Hip: Observation vs. Bracing
Status: NOT_YET_RECRUITING
Conditions: Developmental Dysplasia of the Hip|Hip Dysplasia|Hip Dysplasia, Congenital|Hip Dysplasia, Developmental
Interventions: OTHER: Pavlik Harness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Pea, Lentil and Oat Flour Particle Size on Glycemic Response in Healthy Adults
Status: COMPLETED
Conditions: Malnutrition; Diabetes|Malnutrition; Protein|Obesity
Interventions: OTHER: Crackers made with whole, coarse, or fine pea and/or wheat flour|OTHER: Crackers made with whole, coarse, or fine lentil and/or wheat flour|OTHER: Porridge made with oat flour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Bringing NELIP for Obese Pregnant Women Into Clinical Practice
Status: UNKNOWN
Conditions: Obesity|Pregnancy
Interventions: BEHAVIORAL: Nutrition Lifestyle Intervention Program (NLIP)|BEHAVIORAL: Exercise Lifestyle Intervention Program (ELIP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cediranib Maleate With or Without Lenalidomide for the Treatment of Thyroid Cancer
Status: COMPLETED
Conditions: Refractory Differentiated Thyroid Gland Carcinoma|Refractory Thyroid Gland Follicular Carcinoma|Refractory Thyroid Gland Hurthle Cell Carcinoma|Refractory Thyroid Gland Papillary Carcinoma|Unresectable Thyroid Gland Carcinoma
Interventions: DRUG: Cediranib|DRUG: Cediranib Maleate|OTHER: Laboratory Biomarker Analysis|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Patupilone in Prostate Cancer Patients Who Progress After Hormone Therapy and Docetaxel Chemotherapy
Status: COMPLETED
Conditions: Hormone Refractory Prostate Cancer
Interventions: DRUG: Patupilone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HPV Centralized R/R RCT #2 - New York State
Status: COMPLETED
Conditions: Vaccines
Interventions: BEHAVIORAL: HPV Vaccine Reminder Recall - Autodialer|BEHAVIORAL: HPV Vaccine Reminder Recall - Texting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Nilotinib as First Line Treatment in Philadelphia Chromosome Positive(Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP)
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia
Interventions: DRUG: Nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Anamorelin HCl for the Treatment of Malignancy Associated Weight Loss and Anorexia in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Cachexia; Cancer|Non Small Cell Lung Cancer
Interventions: DRUG: Anamorelin Hydrochloride|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Intranasal Fentanyl for the Treatment of Incident Dyspnea in Congestive Heart Failure: A Prospective Trial
Status: COMPLETED
Conditions: Dyspnea|Congestive Heart Failure
Interventions: DRUG: fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Couple-Based Physical Activity Intervention
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid System Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Best Practice|OTHER: Exercise Counseling|OTHER: Exercise Intervention|OTHER: Medical Device Usage and Evaluation|OTHER: Medical Device Usage and Evaluation|OTHER: Physical Performance Testing|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: GLASSIA Infusion Rate Study
Status: COMPLETED
Conditions: Alpha1-antitrypsin Deficiency|Healthy Volunteers
Interventions: BIOLOGICAL: Alpha1-proteinase inhibitor|BIOLOGICAL: Placebo: Human albumin 2.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy, Safety and Tolerability of Tegaserod Alone and in Combination With Omeprazole Given Orally in Patients With Symptoms of Symptomatic Gastroesophageal Reflux Disease (sGERD)
Status: COMPLETED
Conditions: Symptomatic Gastroespohageal Reflux Disease
Interventions: DRUG: Tegaserod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO)
Status: COMPLETED
Conditions: HIV Infections|Tuberculosis
Interventions: DRUG: Antiretroviral medications|DRUG: Antiretroviral medications+Isoniazid prophylaxis|DRUG: Antiretroviral medications|DRUG: Antiretroviral medications+Isoniazid prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurophysiological and Acute Pharmacological Studies in FXS Patients
Status: COMPLETED
Conditions: Fragile X Syndrome
Interventions: DRUG: Acamprosate|DRUG: Lovastatin|DRUG: Minocycline|DRUG: Placebo|DRUG: Baclofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Alpha and Omega of Lifestyle Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: OTHER: Resistance exercise|DIETARY_SUPPLEMENT: Omega-3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ramatroban/Montelukast Versus Montelukast/Placebo on the Early Allergic Reaction in Asthma Sensitive to House Dust Mite
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: ramatroban|DRUG: montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Seizure Rescue Medication: Caregiver Education in a Simulation Setting
Status: COMPLETED
Conditions: Status Epilepticus
Interventions: OTHER: Verbal Instructions Educational Intervention|OTHER: Video Educational Intervention|OTHER: Mannequin Educational Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PSMA and TARP Peptide Vaccine With Poly IC-LC Adjuvant in HLA-A2 (+) Patients With Elevated PSA After Initial Definitive Treatment
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: Peptide Vaccine|DRUG: Poly IC-LC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study (Study 1) to Evaluate the Safety and Efficacy of FMX103 1.5% Topical Minocycline Foam in the Treatment of Facial Papulopustular Rosacea
Status: COMPLETED
Conditions: Facial Papulopustular Rosacea
Interventions: DRUG: FMX103 minocycline foam 1.5%|DRUG: Vehicle foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Open and Closed System Suctioning on Suctioning Frequency and Amount of Secretion
Status: COMPLETED
Conditions: Secretion; Excess, Salivation
Interventions: PROCEDURE: closed suctioning system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Letrozole Administration During Luteal Phase
Status: NOT_YET_RECRUITING
Conditions: Ovarian Hyperstimulation Syndrome
Interventions: DRUG: Letrozole|DRUG: Polygeline|DRUG: Sodium Chloride|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Long CoronaVirus Disease (COVID) (TLC) Feasibility Trial
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Cetirizine|DRUG: Famotidine|DRUG: Cetirizine Placebo|DRUG: Famotidine Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of TAK-659 as a Single Agent in Adult East Asian Participants With Non-Hodgkin Lymphoma (NHL)
Status: TERMINATED
Conditions: Lymphoma, Non-Hodgkin|Lymphoma, Follicular, Marginal Zone
Interventions: DRUG: TAK-659
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison Between Lingual and Labial Fixed Orthodontic Appliances in the Treatment of Crowding Cases
Status: COMPLETED
Conditions: Crowding
Interventions: DEVICE: Lingual appliances|DEVICE: Labial appliances
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylaxis Versus Treatment for TURP Syndrome.
Status: UNKNOWN
Conditions: Transurethral Resection of Prostate Syndrome
Interventions: DRUG: NaCl 3% HS|DRUG: NaCl 3% HS|DRUG: NaCl 0.9% NS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy & Safety Study of KPT-330 in Erythropoietin-Refractory Lower-Risk Myelodysplastic Syndrome Patients
Status: WITHDRAWN
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Ologen Collagen Matrix Versus Mitomycin-C in Glaucoma Filtering Surgery
Status: COMPLETED
Conditions: Glaucoma
Interventions: DEVICE: Use of ologen Collagen Matrix in trabeculectomy (ologen)|DRUG: Use of Mitomycin-C (MMC) in trabeculectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study on Application of Suturing Parathyroid Markers in Thyroid Cancer Surgery
Status: UNKNOWN
Conditions: Thyroid Cancer|Hypoparathyroidism|Marker; Structural|Complication of Surgical Procedure|Parathyroid Function Low Adverse Event
Interventions: PROCEDURE: The suture marks the location of the parathyroid gland
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing the Efficacy of Metronidazole and Minocycline Gels for the Treatment of Diabetic Periodontitis Patients
Status: COMPLETED
Conditions: Periodontitis|Diabetes Mellitus
Interventions: DRUG: 1ml of 1% metronidazole gel|DRUG: 1ml of 2% minocycline gel|DRUG: 1ml of combination of 1% metronidazole gel and 2% minocycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: MRI-targeted Biopsy of the Prostate: Software Versus Visual Registration in the Accuracy of Prostate Cancer Detection
Status: RECRUITING
Conditions: Prostate Cancer|Prostate Neoplasm
Interventions: PROCEDURE: MRI-targeted prostate biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: INCMGA00012 in Combination With Other Therapies in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unresectable or Metastatic Solid Tumors
Interventions: DRUG: Retifanlimab|DRUG: Epacadostat|DRUG: INCB050465
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Low-Dose Theophylline During Chronic Obstructive Pulmonary Disease (COPD) Exacerbations
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Theophylline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Paclitaxel and Carboplatin or Temozolomide in Treating Patients With Stage IV Melanoma
Status: TERMINATED
Conditions: Melanoma (Skin)
Interventions: DRUG: carboplatin|DRUG: paclitaxel|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Effects of 500mg Trans-resveratrol
Status: COMPLETED
Conditions: Cognitive Performance|Mood
Interventions: DIETARY_SUPPLEMENT: Trans-resveratrol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Transcatheter Arterial Micro-Embolization (TAME) Using Nexsphere-F in Patients With Chronic Pain in Elbow or Wrist
Status: RECRUITING
Conditions: Osteoarthritis
Interventions: DEVICE: Transcatheter Arterial Micro-Embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Endoscopic Based Stent Strategy Versus Bypass Surgery in Non-resectable Periampullary Cancer
Status: WITHDRAWN
Conditions: Pancreatic Neoplasms|Biliary Tract Neoplasms|Duodenal Neoplasms
Interventions: PROCEDURE: surgery|PROCEDURE: endoscopic strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fatigue Self-Management in Primary Care
Status: COMPLETED
Conditions: Medically Unexplained Chronic Fatigue|Chronic Fatigue Syndrome
Interventions: BEHAVIORAL: Cognitive-behavioral self-management|BEHAVIORAL: Symptom monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Ketone Monoesters on Brain Function
Status: NOT_YET_RECRUITING
Conditions: Brain Insulin Sensitivity|Brain Vascular Function|Cerebral Blood Flow|Cognitive Performance|Appetite Control
Interventions: DIETARY_SUPPLEMENT: Ketone Monoester|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pai.ACT - An Artificial Intelligence Driven Chatbot Assisted ACT
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Attention Deficit Hyperactivity Disorder|Neurodevelopmental Disorders|Intellectual Disability|Specific Learning Disorder|Communication Disorders|Motor Disorders
Interventions: BEHAVIORAL: Pai.ACT Group|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Driving Pressure and Postoperative Pulmonary Complications in Thoracic Surgery
Status: COMPLETED
Conditions: One-Lung Ventilation|Postoperative Complications|Driving Pressure|Postoperative Pulmonary Complication|Thoracic Surgery|Positive End Expiratory Pressure
Interventions: OTHER: ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Single Patient Use of Tocilizumab in Systemic Onset Juvenile Idiopathic Arthritis
Status: TERMINATED
Conditions: Arthritis, Juvenile Rheumatoid|Still's Disease, Juvenile Onset
Interventions: BIOLOGICAL: tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Captopril Use on the Degree of Marrow Fibrosis in Bone Marrow Fibrosis/Myeloproliferative Neoplasms
Status: WITHDRAWN
Conditions: Bone Marrow Fibrosis|Myeloproliferative Neoplasm
Interventions: DRUG: Captopril
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of DWP450 in Subjects With Benign Masseteric Hypertrophy
Status: COMPLETED
Conditions: Benign Masseteric Hypertrophy
Interventions: DRUG: DWP450|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oncoquest-L Vaccine in Patients With Previously Untreated Stage III or IV, Asymptomatic, Non-bulky Follicular Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Follicular Lymphoma
Interventions: BIOLOGICAL: Oncoquest-L vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Evaluation of Cardiac Arrhythmias After Transcatheter Aortic Valve Implantation -The LOCATE Registry
Status: RECRUITING
Conditions: Aortic Stenosis|Atrial Fibrillation New Onset|Heart Block
Interventions: DEVICE: TAVR Procedure and implantation of Boston Scientific Loop Recorder (LUX-Dx PMA# K193473)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Test the Combination of Two Different Kinds of Medications for the Treatment of Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: LY2428757|DRUG: TT223|DRUG: Placebo for LY2428757|DRUG: Placebo for TT223
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interdisciplinary Psychoeducational Intervention Programme for Caregivers of Dependent Older Adults
Status: NOT_YET_RECRUITING
Conditions: Dependent Older People|Family Caregiver|Interdisciplinary|Intervention|Occupational Therapy|Psychoeducational|Psychology
Interventions: BEHAVIORAL: Interdisciplinary Psychoeducational Programme|BEHAVIORAL: Health Education Programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Crossover Study Comparing Fluticasone Furoate (FF)/Vilanterol (VI) Once Daily Versus Fluticasone Propionate (FP) Twice Daily in Subjects With Asthma and Exercise-Induced Bronchoconstriction (EIB)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone furoate/ Vilanterol 100 mcg/25 mcg|DRUG: Fluticasone propionate 250 mcg|DRUG: Placebo via ELLIPTA inhaler|DRUG: Placebo via DISKUS / ACCUHALER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Loco-regional Treatment for Hepatocellular Carcinoma Prior to Living Donor Liver Transplantation in Egypt
Status: COMPLETED
Conditions: Hepatocellular Carcinoma (HCC)|Living Donor Liver Transplantation
Interventions: PROCEDURE: loco regional therapies for HCC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of Thigh Muscle After a Stretching Program
Status: COMPLETED
Conditions: Assessment of Muscle Architecture and Tendon After Chronic Stretching Program
Interventions: OTHER: static stretching exercise on 3 times a week during 8 weeks. Sets number: three of 30 seconds with intervals of equal duration
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: BASIC_SCIENCE
Clinical trial: High Doses of Total End Range Time Offer Better Results Than Low Doses Treating Proximal Interphalangeal Joint Stiffness
Status: COMPLETED
Conditions: Proximal Interphalangeal Finger Joint Contractures
Interventions: DEVICE: Elastic Tension Digital Neoprene Orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT