pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Immune-enhancing Enteral Nutrition on Immunomodulation in Critically Ill Patients
Status: COMPLETED
Conditions: Critical Illness
Interventions: DIETARY_SUPPLEMENT: standard enteral nutrition|DIETARY_SUPPLEMENT: high-protein enteral nutrition of immune modulating nutrients enriched with β-glucan|DIETARY_SUPPLEMENT: high-protein enteral nutrition of immune modulating nutrients without β-glucan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Effects of a Web Based Education Programme About Sexuality Aimed at Nurses That Care for Patients With Cancer
Status: ENROLLING_BY_INVITATION
Conditions: Neoplasms|Nurse-Patient Relations|Sexuality
Interventions: OTHER: Bring it up - Assessment and support of patients' sexuality in cancer nursing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Physical Exercise Prescription With PEdometeR in General Practice for Patients With Cardiovascular Risk Factors - PEPPER
Status: COMPLETED
Conditions: Sedentary Lifestyle|Cardiovascular Diseases|Hypertension|Hypercholesterolemia|Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Intervention PPIL|BEHAVIORAL: Control OR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Perindopril to Prevent Recurrence of Atrial Fibrillation in Patients With Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension|Atrial Fibrillation
Interventions: DRUG: Perindopril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quadratus Lumborum Block for Postoperative Analgesia After Colostomy Closure
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: levo-bupivacaine|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Post-marketing Study to Monitor the Safety of a MF59-adjuvanted Influenza Vaccine Administered in Korean Subjects Aged 65 Years or Older
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluad_MF59-adjuvanted trivalent influenza subunit vaccine|BIOLOGICAL: Vantaflu_MF59-adjuvanted trivalent influenza subunit vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial to Evaluate the Combination of Iressa & Faslodex® in Patients With Advanced or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: gefitinib and fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PROCLAIM: Study Examining Effects of Clopidogrel Compared to Placebo on Inflammation in Subjects With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome x
Interventions: DRUG: clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of a New Automated Ventilatory Mode Named Intellivent to Standard Controlled Ventilation in Brain Injured Patients
Status: COMPLETED
Conditions: Brain Injured Patients
Interventions: DEVICE: Intellivent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetic Study Comparing Blood Levels of Dasatinib in Healthy Participants Who Received the Tablet Formulation With Those Who Received Liquid and Tablet-dispersed Formulations
Status: COMPLETED
Conditions: Pharmacokinetic Study in Healthy Participants
Interventions: DRUG: Dasatinib as tablets|DRUG: Dasatinib as liquid|DRUG: Dasatinib as dispersed tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Semaglutide in Comorbid Schizophrenia Spectrum Disorder and Obesity
Status: RECRUITING
Conditions: Schizophrenia Spectrum Disorders
Interventions: DRUG: Semaglutide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Metyrosine (Demser®) for the Treatment of Psychotic Disorders in Patients With Velocardiofacial Syndrome
Status: TERMINATED
Conditions: Velo-cardio-facial Syndrome|Psychosis
Interventions: DRUG: Metyrosine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Label Multi-center Extension Study to Evaluate Long-term Safety/ Tolerability of Dovitinib in Patients With Solid Tumors Who Continue to Receive Treatment With Dovitinib (TKI258) in Novartis-sponsored Single Agent Dovitinib Studies Which Fulfilled the Requirements for the Primary Objective
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: dovitinib|DRUG: fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Depressive Symptoms in Breast Cancer Patients: Comparison of Cognitive Therapy and Bright Light Therapy
Status: COMPLETED
Conditions: Treatment of Depressive Symptoms in Cancer Patients
Interventions: BEHAVIORAL: Cognitive therapy of depression|BEHAVIORAL: Bright light therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of the Utility of Pfizer's Pneumococcal Urine Antigen Test in Children 5 Years of Age or Younger With Community Acquired Pneumonia in Guatemala
Status: COMPLETED
Conditions: Community-acquired Pneumonia|Streptococcus Pneumoniae Infection
Interventions: OTHER: Urinary antigen detection assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Low Dose Ketamine Given at Induction of Anesthesia on Postoperative Mood in Patients With Depressive Symptoms
Status: TERMINATED
Conditions: Depression|Major Depressive Disorder
Interventions: DRUG: ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Intraportal Chemotherapy Combined With Adjuvant Chemotherapy for Stage II and III Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Neoplasms|Neoplasm Metastasis|Liver Neoplasms
Interventions: DRUG: 5-FU and oxaliplatin|PROCEDURE: colorectal cancer resection+ adjuvant chemotherapy (mFOLFOX6)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Investigate the Single Dose Pharmacokinetics of Insulin Degludec/Liraglutide in Healthy Chinese Subjects
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: insulin degludec/liraglutide|DRUG: Xultophy®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Levetiracetam Versus Standard Antiepileptic Drugs (Carbamazepine and Valproate) Used as Monotherapy in Patients With Newly Diagnosed Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Levetiracetam|DRUG: Carbamazepine Controlled Release (CBZ-CR)|DRUG: Valproate Extended Release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of sNN0029 Administration Via Intracerebroventricular Route to Patients With ALS
Status: TERMINATED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: sNN0029|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Remimazolam Tosilate for Sedation in the ICU
Status: COMPLETED
Conditions: Sedation in the ICU
Interventions: DRUG: Remimazolam Tosilate|DRUG: Remimazolam Tosilate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nilotinib Versus Imatinib in Treatment of Patients With Newly Diagnosed Chronic Myeloid Leukemia
Status: UNKNOWN
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Nilotinib 150 MG [Tasigna]|DRUG: Imatinib 400mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Lumpectomy Followed By Intraoperative Electron Radiation Therapy (IOERT)
Status: WITHDRAWN
Conditions: Invasive Ductal Breast Cancer|Carcinoma Breast Stage I
Interventions: RADIATION: Intraoperative Electron Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of JS009 Monotherapy and JS009 as a Triple Combination Therapy in Patients With Advanced Malignancies
Status: WITHDRAWN
Conditions: Primary Condition: Advanced Tumors
Interventions: DRUG: JS009 as a monotherapy and JS009 as a Triple Combination Therapy in Combination with Toripalimab and JS006
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Type 2 Diabetic Patients Maintained on Statin Therapy
Status: COMPLETED
Conditions: Dyslipidemia Associated With Type II Diabetes Mellitus
Interventions: DRUG: Atorvastatin 40 Mg Oral Tablet|DRUG: Rosuvastatin 10 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Transcranial Direct Current Stimulation and Effects on Early Auditory Processing in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: COMBINATION_PRODUCT: Active tDCS + Auditory Training|COMBINATION_PRODUCT: Active tDCS + Control Condition|COMBINATION_PRODUCT: Sham tDCS + Auditory Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Effectiveness of the Selected Method of Treatment of Primary Burning Mouth Syndrome
Status: COMPLETED
Conditions: Burning Mouth Syndrome|Glossodynia
Interventions: DRUG: Clonazepam tablets|DEVICE: tongue pads
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Heat and Intravenous Fluids for Exogenous Rewarming
Status: COMPLETED
Conditions: Hypothermia
Interventions: OTHER: Warmed IV fluids|OTHER: Warmed perfusion pads
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia
Status: COMPLETED
Conditions: Pneumonia, Pneumocystis Carinii|HIV Infections
Interventions: DRUG: Pentamidine isethionate|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: 3-year Follow-up Study to Assess the Viral Activity in Hepatitis C Patients Who Failed Feeder DEB025/Alisporivir Study
Status: TERMINATED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Previous treatment in DEB025 study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of AK117 in Combination With Azacitidine in Patients With Myelodysplastic Syndromes
Status: RECRUITING
Conditions: Higher-risk Myelodysplastic Syndromes
Interventions: DRUG: AK117|DRUG: Placebo|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reasons for Mycophenolate Mofetil Dose Reduction and Impact on Graft Outcome in Renal Transplant Recipients
Status: COMPLETED
Conditions: Acute Rejection of Renal Transplant|Renal Graft Loss
Interventions: OTHER: no intervention, this is an observational retrospective trial
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intervening in Diabetes With Healthy Eating, Activity, and Linkages To Healthcare - The I-D-HEALTH Study
Status: COMPLETED
Conditions: Diabetes Mellitus|Hyperglycemia|Obesity|Glucose Metabolism Disorders|Metabolic Diseases|Endocrine System Diseases|Overnutrition|Nutrition Disorders|Overweight|Body Weight|Signs and Symptoms
Interventions: BEHAVIORAL: Standard Lifestyle Advice|BEHAVIORAL: Advice Plus Lifestyle Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: cisplatin|DRUG: gemcitabine hydrochloride|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tai Ji Quan and Cognitive Function in Older Adults With Mild Cognitive Impairment
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: The Go for Exercise & Healthy Aging Project
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Safety, Tolerability and Pharmacokinetics of SUVN-911 in Healthy Subjects
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: SUVN-911|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety & Immunogenicity of 2 or 3 Doses of GSK HRV Vaccine in Healthy Infants in South Africa
Status: COMPLETED
Conditions: Infections, Rotavirus
Interventions: BIOLOGICAL: HRV vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Baclofen Treatment of Ataxia Telangiectasia
Status: COMPLETED
Conditions: Ataxia Telangiectasia
Interventions: DRUG: Baclofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sitagliptin Regulation of Intestinal and Hepatic Lipoprotein Particle and Hepatic Glucose Production in Humans
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DRUG: Sitagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multicentre Study to Determine the Feasibility of Using an Integrated Consent Model to Compare Three Standard of Care Regimens for The Treatment of Triple-Negative Breast Cancer in the Neoadjuvant/Adjuvant Setting (REaCT-TNBC)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Dose dense AC-P|DRUG: Dose dense AC|DRUG: FEC-D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Zinc for HIV Disease Among Alcohol Users - an RCT in the Russia ARCH Cohort
Status: COMPLETED
Conditions: HIV Infection|Alcohol Use
Interventions: DIETARY_SUPPLEMENT: Zinc gluconate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Niacin Supplementation in Healthy Controls and Mitochondrial Myopathy Patients
Status: COMPLETED
Conditions: Mitochondrial Myopathies
Interventions: DIETARY_SUPPLEMENT: Niacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Acute Graft Versus-Host Disease
Status: TERMINATED
Conditions: Acute Graft-versus-Host Disease
Interventions: DRUG: Methoxsalen+ECP, Methylprednisolone|PROCEDURE: Ecp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Childhood Favorable Prognosis Hodgkin Lymphoma|Childhood Lymphocyte Depletion Hodgkin Lymphoma|Childhood Mixed Cellularity Hodgkin Lymphoma|Childhood Nodular Sclerosis Hodgkin Lymphoma|Stage I Childhood Hodgkin Lymphoma|Stage II Childhood Hodgkin Lymphoma
Interventions: RADIATION: radiation therapy|DRUG: doxorubicin hydrochloride|DRUG: vincristine sulfate|DRUG: prednisone|DRUG: cyclophosphamide|DRUG: ifosfamide|DRUG: vinorelbine tartrate|DRUG: dexamethasone|DRUG: etoposide phosphate|DRUG: cisplatin|DRUG: cytarabine|BIOLOGICAL: filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Continuous Airway Pressure on the Ability to Heat and Humidify Air
Status: COMPLETED
Conditions: Healthy
Interventions: PROCEDURE: Continuous positive airway pressure (CPAP) at -5, 0, 5 and 10 cm of water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Study Of The Analgesic (Pain-Relief) Effects Of Tanezumab In Adult Patients With Diabetic Peripheral Neuropathy
Status: TERMINATED
Conditions: Diabetic Peripheral Neuropathy
Interventions: BIOLOGICAL: Tanezumab|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson's Disease|Mild Cognitive Impairment
Interventions: DEVICE: Combined STN+NBM DBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigations of Amygdala Function Using Neurophysiological Recording and Stimulation
Status: COMPLETED
Conditions: Fear|PTSD|Panic Disorder
Interventions: DEVICE: Amygdala recording and stimulation using Neuropace RNS|BEHAVIORAL: Behavioral tasks
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Attachment Inhibitor Comparison in Heavily Treatment Experienced Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections
Interventions: DRUG: BMS-663068|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Abemaciclib (LY2835219) Combined With Fulvestrant in Women With Hormone Receptor Positive HER2 Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Neoplasms
Interventions: DRUG: Abemaciclib|DRUG: Fulvestrant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Tolerability Study of Otelixizumab in Thyroid Eye Disease
Status: TERMINATED
Conditions: Graves Ophthalmopathy
Interventions: DRUG: Otelixizumab - low dose|DRUG: Otelixizumab - medium low dose|DRUG: Otelixizumab - medium high dose|DRUG: Otelixizumab - high dose|DRUG: Otelixizumab|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Negative Pressure Wound Therapy and Conventional Wound Dressings Before and After Split-Thickness Skin Grafting in Diabetic Foot Wounds
Status: RECRUITING
Conditions: Negative-Pressure Wound Therapy|Diabetic Foot
Interventions: DEVICE: Negative Pressure Wound Therapy (NPWT)|OTHER: Ordinary dressings with antibiotic ointment and gauze
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability and Efficacy Study of LiRIS® 400 mg in Women With Interstitial Cystitis
Status: TERMINATED
Conditions: Interstitial Cystitis
Interventions: DRUG: LiRIS 400 mg|OTHER: LiRIS Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of AI EF Screening by Using Smartphone Application Recorded PLAX View Cardiac Ultrasound Video Clips
Status: COMPLETED
Conditions: Heart Failure|Heart Failure With Reduced Ejection Fraction|Cardiac Failure|Echocardiography|Artificial Intelligence
Interventions: OTHER: Easy EF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination Chemotherapy in Treating Patients With Stage III or Stage IV Pancreatic Cancer That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: cisplatin|DRUG: fluorouracil|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Efficacy of Elbasvir/Grazoprevir Fixed-Dose Combination for 8 Weeks in Treatment-Naïve, HCV GT1b-Infected Patients, With Non-severe Fibrosis
Status: COMPLETED
Conditions: Chronic HCV Infection
Interventions: DRUG: Elbasvir/Grazoprevir Fixed Dose Combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-blind, Two-arm Study Comparing the Efficacy and Safety of Trazodone Contramid® OAD and Placebo in the Treatment of Unipolar Major Depressive Disorder.
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Trazodone Hydrochloride (HCl) Extended-Release Tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Audit of the Impact of Tailored Information Delivered Via a Digital Learning Platform
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2|Diabetes Mellitus, Type 1
Interventions: BEHAVIORAL: training in optimal insulin injection technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Evaluate the Efficacy and Safety of Wenxin Keli in Treating Atrial Premature Beats
Status: UNKNOWN
Conditions: Atrial Premature Beats
Interventions: DRUG: Low dose WenXin keli|DRUG: High dose WenXin keli
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Infusion of Dexamethasone Plus Tramadol Adjunct to Morphine PCA After Abdominal Hysterectomy
Status: COMPLETED
Conditions: Postoperative Pain|Post Operative Analgesia|Patient-Controlled Analgesia|Abdominal Surgeries
Interventions: DRUG: Dexamethasone Sodium Phosphate Injection|OTHER: 0.9% Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Ranging Phase 2b Study of ABX464 in Moderate to Severe Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: ABX464 25mg|DRUG: ABX464 50mg|DRUG: ABX464 100mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Co-Administration of Roluperidone and Olanzapine in Adult Subjects With Moderate to Severe Negative Symptoms of Schizophrenia
Status: COMPLETED
Conditions: Negative Symptoms in Schizophrenia
Interventions: DRUG: Roluperidone 64 mg|DRUG: Olanzapine 10 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resistance Plus Aerobic Training Using Different Weekly Frequencies And Hypertension
Status: UNKNOWN
Conditions: Hypertension|Cardiovascular Risk Factor|Cardiovascular Diseases
Interventions: BEHAVIORAL: Combined training performed four times per week (CT4)|BEHAVIORAL: Combined training performed two times per week (CT2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multiple Ascending Dose Study of BCI-838 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BCI-838|DRUG: BCI-838|DRUG: BCI-838
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Sarpogrelate on Platelet Aggregation in Patients With Cerebral Infarction: Dose-responsive Clinical Pharmacology Study
Status: COMPLETED
Conditions: Cerebral Infarction
Interventions: DRUG: MCI-9042
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electroacupuncture Versus Fast-track Perioperative Program for Laparoscopic Colorectal Surgery
Status: UNKNOWN
Conditions: Postoperative Ileus
Interventions: PROCEDURE: Electroacupuncture|PROCEDURE: Fast-track program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyoscine Butyl Bromide in Reducing Pain During HSG
Status: COMPLETED
Conditions: Pain Relief With HSG
Interventions: DRUG: hyoscine butyl bromide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: First-in-human Study to Examine Safety of a New Peritoneal Dialysis Device (WEAKID) in End-stage Kidney Disease Patients
Status: RECRUITING
Conditions: Renal Insufficiency, Chronic|Kidney Failure, Chronic|Chronic Kidney Diseases
Interventions: DEVICE: WEAKID
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: L-NMMA Plus Taxane Chemotherapy in Refractory Locally Advanced or Metastatic Triple Negative Breast Cancer Patients
Status: COMPLETED
Conditions: Metastatic Triple Negative Breast Cancer
Interventions: DRUG: L-NMMA|DRUG: Docetaxel|DRUG: Amlodipine|DRUG: Pegfilgrastim|DRUG: Enteric-coated aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digital Health Intervention for Caregivers Emotional and Self-management Support of Children With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: BEHAVIORAL: Adhera® Caring digital intervention for Type 1 Diabetes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of LY2140023 in Schizophrenia Patients With Prominent Negative Symptoms
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: LY2140023|DRUG: Placebo|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Human Placenta-derived Cells (PDA001) to Evaluate the Safety and Effectiveness for Patients With Active Rheumatoid Arthritis
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: PDA001|DRUG: Vehicle Controlled Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Intranasal Administration of a Single Dose of Oxytocin Using a Novel Device in Adults With Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DRUG: 8IU intranasal oxytocin|DRUG: 24IU intranasal oxytocin|DRUG: Placebo|DEVICE: OptiNose Breath Powered Bi
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Disrupting Prolonged Sitting With Different Physical Activity Protocols on Metabolic Risk Factors in Sedentary Adults
Status: UNKNOWN
Conditions: Prolonged Sitting|Breaking Prolonged Sitting With Physical Activity
Interventions: BEHAVIORAL: Breaking prolonged sitting with physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors
Status: COMPLETED
Conditions: Glioblastoma|Astrocytoma|Pineoblastoma|Rhabdoid Tumor|Supratentorial Neoplasms
Interventions: PROCEDURE: Stem Cell Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Methylprednisolone on Glucose Homeostasis in Patients Undergoing Total Hip- and Knee-arthroplasty
Status: COMPLETED
Conditions: Osteoarthrosis
Interventions: DRUG: Methylprednisolone|DRUG: Isotonic Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: High-Dose Interleukin-2 (HDIL-2), Combined With recMAGE-A3 + AS15 ASCI
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: HDIL-2|BIOLOGICAL: recMAGE-A3 + AS15
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Remnant Liver Function Using Primovist-enhanced MRI Before Resection/Ablation of Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular|Liver Dysfunction
Interventions: DRUG: Gd-EOB-DTPA|DRUG: Gd-EOB-DTPA|PROCEDURE: MRI|PROCEDURE: MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Study of Medical Thoracoscope Cryotherapy Combined Standard First-line Treatment of Advanced Non-small Cell Lung Cancer and Malignant Pleural Effusion
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: OTHER: Medical thoracoscopic cryotherapy combined with standard first-line therapy for advanced non-cell lung cancer|OTHER: Sequential intrathoracic injection of cisplatin/erythromycin combined with standard first-line therapy for advanced non-cell lung cancer|OTHER: Standard first-line therapy for advanced non-cell lung cancer without intrathoracic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Fortiva and Strattice Tissue Matrices in Complex, Ventral Hernia Repair
Status: COMPLETED
Conditions: Ventral Hernia
Interventions: DEVICE: Fortiva™ Porcine Dermis|DEVICE: Strattice™ Reconstructive Tissue Matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Eribulin in Combination With Oral Irinotecan for Adolescent and Young Adult Patients With Relapsed or Refractory Solid Tumors
Status: COMPLETED
Conditions: Relapsed Solid Tumors|Refractory Solid Tumors
Interventions: DRUG: Eribulin|DRUG: Irinotecan|OTHER: Cefixime
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of HX008 And Niraparib in GErm-line-mutAted Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Treatment Efficacy
Interventions: DRUG: HX008，Niraparib|DRUG: HX008，Niraparib|DRUG: HX008，Niraparib，Trastuzumab|DRUG: HX008，Niraparib，Pyrrolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bilateral Lateral Rectus Recession Versus Unilateral Recess-Resect for Intermittent Exotropia
Status: COMPLETED
Conditions: Exotropia
Interventions: PROCEDURE: Bilateral lateral rectus recession (BLRc)|PROCEDURE: Unilateral lateral rectus recession with medial rectus resection (R&R)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Temsirolimus (Torisel®) and Erlotinib (Tarceva®) in Platinum-Refractory/Ineligible, Advanced, Squamous Cell Carcinoma
Status: TERMINATED
Conditions: Squamous Cell Carcinoma
Interventions: DRUG: Erlotinib|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Clinical Study to Assess Safety and to Collect Data on Radiofrequency Microneedling Device(s) For the Purpose of Evaluating Treatment on Skin
Status: COMPLETED
Conditions: Dermatologic Conditions
Interventions: DEVICE: Potenza|DEVICE: Morpheus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Atezolizumab Combination Carboplatin + Paclitaxel + Bevacizumab in EGRF Mutation or ALK Translocation NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Atezolizumab(Tecentriq)|DRUG: Pemetrexed|DRUG: Bevacizumab|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Carboplatin or cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monitoring Heart Rate Variability for the Early Detection of Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Ductal Adenocarcinoma|Stage I Pancreatic Cancer AJCC v8|Stage IA Pancreatic Cancer AJCC v8|Stage IB Pancreatic Cancer AJCC v8
Interventions: DEVICE: Activity Monitor|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Segmentectomy for Ground Glass-dominant Invasive Lung Cancer (ECTOP-1012)
Status: RECRUITING
Conditions: Segmentectomy|Lung Adenocarcinoma
Interventions: PROCEDURE: Segmentectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Elastic Bandage on Balance in Chronic Ankle Instability
Status: COMPLETED
Conditions: Ankle Sprain
Interventions: DEVICE: Elastic Bandage (Idealplast C®)|DEVICE: Pretape cramer® (non standarized tape)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Long-term Study of AK102 in Patients With Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: 450mg AK102|DRUG: 300mg AK102|DRUG: 150mg AK102|DRUG: Statins and/or Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel and Carboplatin in Women With Malignant Mixed Mullerian Tumors (MMMT) of the Uterus
Status: COMPLETED
Conditions: Mixed Tumor, Mullerian
Interventions: DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telemedicine in the Management of Pain in Patients With Advanced or Metastatic Pancreatic Cancer
Status: UNKNOWN
Conditions: Adenocarcinoma|Pancreatic Cancer Metastatic|Pain
Interventions: OTHER: Telemedicine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Platelet Activity in Vascular Surgery for Thrombosis and Bleeding
Status: COMPLETED
Conditions: Peripheral Vascular Disease|Peripheral Artery Disease|Carotid Stenosis|Aortic Aneurysm, Abdominal|Aortic Aneurysm, Thoracic|Amputation, Wound|Embolism and Thrombosis|Aortic Aneurysm
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of A Long Lasting Local Anesthestic for Hand, Wrist or Finger Surgery
Status: TERMINATED
Conditions: Hand Injuries|Wrist Injuries|Finger Injuries
Interventions: DRUG: Exparel Forearm block|DRUG: Bupivacaine supraclavicular block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short-term Effect of Chewing Gum in Patients With Mild-moderate Dysphagia After Anterior Cervical Fusion
Status: UNKNOWN
Conditions: Dysphagia
Interventions: OTHER: chewing gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Rebif® New Formulation (Interferon-beta-1a) in Relapsing Remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Rebif® New Formulation (IFN-beta-1a, RNF)|DRUG: Placebo|DRUG: Rebif® New Formulation (IFN-beta-1a, RNF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Check the Efficacy and Safety of Recombinant BCG Vaccine in Prevention of TB Recurrence
Status: ACTIVE_NOT_RECRUITING
Conditions: Prevention of TB Recurrence
Interventions: BIOLOGICAL: VPM1002 (Recombinant BCG Vaccine)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Radiation Fractionation on Patient Outcomes After Breast REConstruction (FABREC) for Invasive Breast Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Feasibility Study: tDCS for Treatment of Refractory Status Epilepticus
Status: RECRUITING
Conditions: Status Epilepticus|Refractory Status Epilepticus
Interventions: DEVICE: Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Four-way Crossover Study of 3 Formulations of M207 With Intranasal Zolmitriptan in Healthy Volunteers
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: M207 3.8 mg "Sled" (two 1.9 mg patches made on a "Sled" coater, foil pouches)|DRUG: M207 3.8 mg "MACAP" (two 1.9 mg patches made on a "MACAP" coater, foil cups)|DRUG: M207 3.8 mg "MiniMac" (two 1.9 mg patches made on a "MiniMac" coater, foil cups|DRUG: Zolmitriptan 2.5 mg/0.1 mL nasal spray [ZOMIG] single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Study of KW-3357
Status: COMPLETED
Conditions: Disseminated Intravascular Coagulation (DIC)
Interventions: DRUG: KW-3357|DRUG: Plasma-derived antithrombin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Extension Treatment With Etanercept (TNFR:Fc) for Participating Patients in Etanercept (TNFR:Fc) Clinical Trials
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sedation Methods During Cataract Surgery
Status: COMPLETED
Conditions: Phacoemulsification|Cataract
Interventions: DRUG: Midazolam + Ketamine 10 MG/ML: 0.5 ML|DRUG: Midazolam + Ketamine 10 MG/ML: 1 ML|DRUG: Midazolam + Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Medical Cannabis Oil in the Treatment of Patients With Chronic Pain
Status: UNKNOWN
Conditions: Chronic Pain
Interventions: DRUG: THC and CDB in a 1 to 1 ratio|DRUG: Experimental: THC and CBD in a 1 to 2 ratio|DRUG: High CBD with trace THC oil|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Assessing the Efficacy of Combined Use of Clascoterone 1% Cream and Adapalene 0.3% for the Treatment of Acne
Status: ACTIVE_NOT_RECRUITING
Conditions: Acne Vulgaris
Interventions: DRUG: Winlevi (clascoterone) 1% & Adapalene 0.3% gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells
Status: UNKNOWN
Conditions: Tracheal Stenosis|Laryngeal Stenosis
Interventions: BIOLOGICAL: Olfactory mucosa-derived mesenchymal stem cells|OTHER: Patients treated according to current clinical protocols
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Disease Activity of Intravenously (IV) Infused Telisotuzumab Vedotin in Adult Participants With Advanced/Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: Telisotuzumab Vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness on Smooth Extubation According to the Administration Time of Sugammadex
Status: NOT_YET_RECRUITING
Conditions: Sugammadex|Extubation|Smooth Emergence
Interventions: DRUG: sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Pistacia Mutica on De Novo Dental Plaque Formation, Gingival Inflammation and Oral Microorganisms
Status: COMPLETED
Conditions: Gingivitis
Interventions: DRUG: pistacia Mutica extract|DRUG: Placebo|DRUG: Chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Functional Brain Imaging of Medication Treatment Response in Mild Alzheimer's Disease Patients
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: Razadyne ER|DRUG: Aricept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of 12-week Probiotic Supplementation on Bacterial and Viral Infections in Infants Aged 6 to 12 Months.
Status: COMPLETED
Conditions: Effect of Probiotics on Infections in Infants.
Interventions: DIETARY_SUPPLEMENT: Lactobacillus rhamnosus|DIETARY_SUPPLEMENT: Bifidobacterium animalis subsp. lactis|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of the Effects of MDMA/Ecstasy on Water Regulation, Sleep, and Cognition.
Status: COMPLETED
Conditions: MDMA Discontinuation Syndrome
Interventions: DRUG: 3,4-methylenedioxymethamphetamine or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Planetary Health Diet Recommendation Using Mobile Application in Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Health Behavior|Overweight and Obesity|Eating Behavior|Calorie Overload
Interventions: OTHER: Counseling on planetary health diet with calorie restriction|OTHER: Counseling on balanced nutrition diet with calorie restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Technique for Difficult Intubation
Status: COMPLETED
Conditions: Intubation; Difficult|Failed or Difficult Intubation|Failed or Difficult Intubation, Initial Encounter|Anesthesia Intubation Complication
Interventions: DEVICE: Videolaryngoscope and Bonfils
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: