pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase 0 Study in Healthy, Hepatic and Renal Impaired Subjects to Obtain Plasma for Lenvatinib Protein Binding
Status: COMPLETED
Conditions: Hepatic Impairment; Renal Impairment
Interventions: DRUG: Plasma Sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Genomics and Epigenomics of the Elderly Response to Pneumococcal Vaccines
Status: COMPLETED
Conditions: Pneumonia|Aging
Interventions: BIOLOGICAL: Pneumococcal 13valent Conj Vaccine Diphtheria CRM197 Protein|BIOLOGICAL: Pneumococcal Vaccine Polyvalent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of the Consumption of Probiotics in the Reduction of Incidence of Carious Lesions in Preschool Children
Status: COMPLETED
Conditions: Caries Reduction|Caries Prevention
Interventions: DIETARY_SUPPLEMENT: Experimental: Probiotic enriched milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lasix for the Prevention of De Novo Postpartum Hypertension
Status: COMPLETED
Conditions: Postpartum Pregnancy-Induced Hypertension|Postpartum Preeclampsia|Hypertension, Pregnancy-Induced|Hypertension
Interventions: DRUG: Furosemide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Oxandrolone Rotator Cuff Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Rotator Cuff Tear
Interventions: DRUG: Oxandrolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IVC and Lung Ultrasound B-lines Guided Decongestion in Critically Ill ESKD Patients With Heart Failure
Status: ENROLLING_BY_INVITATION
Conditions: End-stage Renal Disease
Interventions: PROCEDURE: Lung and inferior vena cava ultrasound guidance|PROCEDURE: Conventional protocol guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Kritech Efficacy on Subjects Having Functional Discomfort Associated to Joints and Muscles Disorders
Status: COMPLETED
Conditions: Pain
Interventions: DIETARY_SUPPLEMENT: Kritech administration|OTHER: Placebo adminstration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Ultrasonic Study of Post Operative Diaphragmatic Dysfunction in Abdominal and Head and Neck Surgery
Status: COMPLETED
Conditions: Diaphragmatic Dysfunction
Interventions: PROCEDURE: Diaphragmatic amplitude measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Extension Study to Evaluate Safety and Tolerability of Oral Dersimelagon (MT-7117) in Subjects With Erythropoietic Protoporphyria (EPP) or X-Linked Protoporphyria (XLP)
Status: ACTIVE_NOT_RECRUITING
Conditions: EPP|XLP
Interventions: DRUG: MT-7117
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Pharmacist Follows You and Your Medication From Hospital to Your Daily Life and Investigate What This Means to You
Status: COMPLETED
Conditions: Cross-Sectional Study
Interventions: OTHER: basic intervention|OTHER: extended intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 1 Study to Evaluate the Pharmacokinetics of Setmelanotide in Subjects With Varying Degrees of Renal Impairment
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: DRUG: Setmelanotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Assess Intracerebroventricular (ICV) Delivery of CT-010 in Subjects With Focal Seizures, With Temporal Lobe Onset With or Without Secondary Generalization
Status: TERMINATED
Conditions: Refractory Epilepsy
Interventions: COMBINATION_PRODUCT: ICV delivery of CT-010 via an implantable pump and a cranial port and dual lumen catheter (CIC)|COMBINATION_PRODUCT: Placebo delivery via an implantable pump and a cranial port and dual lumen catheter (CIC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ACZ885 in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Canakinumab|DRUG: Placebo|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: vHIT Testing for Presentation of Dizziness at a Comprehensive Stroke Center
Status: COMPLETED
Conditions: Stroke, Acute|Vertigo|Vertigo, Peripheral|Dizziness|Dizziness; Syndrome
Interventions: DEVICE: Video Head Impulse Testing|OTHER: Standard of care neurologic evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence Trial of Concor AM® vs Bisoprolol and Amlodipine in Chinese Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Bisoprolol-Amlodipine FDC|DRUG: Bisoprolol|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Role of Minimally Invasive Surgery in Management of Penetrating Abdominal Trauma in Children
Status: COMPLETED
Conditions: Penetrating Abdominal Trauma
Interventions: PROCEDURE: Minimally invasive surgery (laparoscopy and laparoscopic-assisted procedures) in both diagnosis and treatment of penetrating abdominal trauma in Children
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: To Examine if the Mother's Glucose Levels and Glucose Levels in the Blood Can Predict Cord Hypoglycemia in Newborns at Risk.
Status: UNKNOWN
Conditions: Neonatal Hypoglycemia
Interventions: PROCEDURE: Blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Efficacy and Safety of HR18042 Tablets for Postoperative Analgesia After Impacted Teeth Removal Surgery.
Status: UNKNOWN
Conditions: Pain
Interventions: DRUG: HR18042 tablets|DRUG: HR18042 tablets|DRUG: HR18042 tablets|DRUG: Tramadol hydrochloride SR Tablets|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Low Flow" CO2 Removal on RRT
Status: COMPLETED
Conditions: Renal Replacement Therapy
Interventions: DEVICE: Extracorporeal CO2 removal with the Prismalung(R) gas exchanger on the Prismaflex(R) renal replacement platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Effects of Prasugrel Compared With Ticagrelor in Patients With Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Prasugrel|DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Romidepsin in Combination With Lenalidomide in Adults With Relapsed or Refractory Lymphomas and Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma|Non-Hodgkin's Lymphoma
Interventions: DRUG: Romidepsin|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Remimazolam Tosilate Compared to Propofol for General Anesthesia During Elective Surgery
Status: COMPLETED
Conditions: Anesthesia for Elective Surgery Patients
Interventions: DRUG: Remimazolam Tosilate|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Randomized Controlled Study to Evaluate the Safety and Efficacy of the Super-Bore 8F Thrombosis Aspiration Catheter in the Treatment of Acute Intracranial Large Vessel Occlusion
Status: RECRUITING
Conditions: Acute Ischemic Stroke|Endovascular Thrombectomy
Interventions: PROCEDURE: Super-Bore 8F Thrombosis Aspiration Catheter treatment group|PROCEDURE: Conventional thrombectomy device treatment group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Flavoured Milk
Status: COMPLETED
Conditions: Saliva Altered|Oral Hygiene|pH|Tooth Structure; Disorder
Interventions: OTHER: Group 1: no intervention|OTHER: Group 2: tap water gargle|OTHER: Group 3: 0.2% Chlorhexidine|OTHER: Group 4: Fluoridated tooth paste|OTHER: Group 5: Polyol containing gum|OTHER: Group 6: 1% sodium bicarbonate solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Raloxifene on Coagulation System in the Postmenopausal Women
Status: COMPLETED
Conditions: Raloxifene|Postmenopausal Women
Interventions: DIAGNOSTIC_TEST: coagulation system parameters; factor 8, von Willebrand factor, protein C, protein S, antithrombin III and fibrinogen were studied.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safest Dose Range for FEIBA in Hemophilia A Patients With Inhibitors on Emicizumab
Status: ACTIVE_NOT_RECRUITING
Conditions: Hemophilia A With Inhibitor
Interventions: DRUG: Feiba
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Muscle Stimulation in Advanced Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DEVICE: Active NMES|DEVICE: Sham NMES|OTHER: Home exercise programme|OTHER: Breathlessness advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Peri Implant Soft Tissue Esthetics With Immediate Temporization With and Without Subepithelial Connective Tissue Graft
Status: UNKNOWN
Conditions: Immediate Temporization and Soft Tissue Augmentation Around Delayed Implants
Interventions: PROCEDURE: delayed implant with immediate provisionaliztion and soft tissue graft|PROCEDURE: delayed implant placement with immediate provisionalization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endarterectomy vs Stenting in Chinese Asymptomatic Carotid Stenosis Patients
Status: UNKNOWN
Conditions: Carotid Stenosis
Interventions: PROCEDURE: Carotid Artery Stenting|PROCEDURE: Carotid Endarterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Research About CD70-targeted CAR-T in the Treatment of CD70-positive Advanced/Metastatic Solid Tumors
Status: RECRUITING
Conditions: Renal Cell Carcinoma|Ovarian Cancer|Cervix Cancer|Metastatic Cancer|Advanced Cancer
Interventions: BIOLOGICAL: CD70 CAR-T cells|BIOLOGICAL: CD70 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dexamethasone on the Duration and Functionality of Bupivacaine Intercostal Nerve Blockade
Status: UNKNOWN
Conditions: Post Minimally Invasive Thorascopic Surgical Pain
Interventions: DRUG: Bupivacaine and Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Comparing Tolerance of Oral Heme Iron Polypeptide With Oral Ionic Iron
Status: WITHDRAWN
Conditions: Iron Deficiency
Interventions: DRUG: ionic iron|DRUG: heme iron polypeptide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Education and Nursing Support Program for Supportive Care, in Patients Treated With Hormone Therapy for Non-metastatic Breast Cancer
Status: RECRUITING
Conditions: Neoplasm of Breast
Interventions: OTHER: Therapeutic Education and Nursing Support Program for Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Comparative Study of Endoscopic Submucosal Dissection and Photodynamic Therapy for Early Esophageal Cancer
Status: NOT_YET_RECRUITING
Conditions: Esophageal Carcinoma in Situ AJCC V7
Interventions: PROCEDURE: PDT|PROCEDURE: ESD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognition in Motion
Status: COMPLETED
Conditions: Cognitive Performance During Physical Activity
Interventions: BEHAVIORAL: Experimental: Standing Modality|BEHAVIORAL: Experimental: Biking Modality|BEHAVIORAL: Experimental: Walking Modality|BEHAVIORAL: No Intervention: Seated Modality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Maintaining Immune and Mitochondrial Functions in Old Adults With SAfe Nutrition.
Status: NOT_YET_RECRUITING
Conditions: Malnutrition|Sarcopenia
Interventions: DIETARY_SUPPLEMENT: BCAA|DIETARY_SUPPLEMENT: Micronutriments|DIETARY_SUPPLEMENT: standard treatment + placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glutathione and Function in HIV Patients
Status: COMPLETED
Conditions: HIV Infection|Erythrocyte Glutathione Deficiency
Interventions: DIETARY_SUPPLEMENT: GlyNAC (combination of glycine and n-acetylcysteine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The DigIT Trial: The Effectiveness and Implementation of a Coached Digital Insomnia Treatment Program in a Regional Healthcare System.
Status: ENROLLING_BY_INVITATION
Conditions: Insomnia Disorder
Interventions: BEHAVIORAL: Virtual Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: PDD in Type 2 Diabetes w/wo Diastolic Dysfunction
Status: ENROLLING_BY_INVITATION
Conditions: Diabetes Mellitus, Type 2|Diastolic Dysfunction
Interventions: DRUG: LCZ 696|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Food Effect of BLU-782 in Healthy Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: BLU-782|DRUG: Placebo|DRUG: BLU-782 taken with food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility and Acceptability of HPV Self-Collection Cervical Cancer Screening and Treatment in Botswana
Status: COMPLETED
Conditions: Human Papillomavirus Infection|Cervical Cancer
Interventions: DIAGNOSTIC_TEST: HPV self collection, followed by visual assessment of the cervix for treatment (VAT) and treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Assessment of Changes in Oral Health-related Quality of Life , Oral Hygiene Status and Body Growth in CSHCN Following Dental Treatment Under General Anaesthesia
Status: UNKNOWN
Conditions: Quality of Life|General Anesthesia|Children With Special Health Care Needs|Body Mass Index
Interventions: PROCEDURE: Full mouth rehabilitation under general anaesethia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Hypnotic Properties of Zolpidem-MR 12.5 mg and Zolpidem 10 mg Marketed Product Compared to Placebo in Patients With Primary Insomnia
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders
Interventions: DRUG: zolpidem-MR (modified release)|DRUG: zolpidem (SL800750)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy of EZC Pak in Adults With Upper Respiratory Infection (URI)
Status: COMPLETED
Conditions: Common Cold
Interventions: DIETARY_SUPPLEMENT: EZC Pak|DIETARY_SUPPLEMENT: EZC Pak +D|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GLP1R-imaging in Post-RYGB Hypoglycemia
Status: RECRUITING
Conditions: Obesity|Hypoglycemia Post Gastric Bypass Surgery|Hyperinsulinemic Hypoglycemia
Interventions: DIAGNOSTIC_TEST: GLP-1R PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PT-CY With or Without Low-dose ATG for Lymphoid Malignancies Undergoing Allo-HSCT
Status: COMPLETED
Conditions: GVHD, Acute
Interventions: DRUG: PT-CY-FK +/-ATG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 2, Open-Label Study of ABSK-011 Combined Atezolizumab in HCC Patients
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: ABSK-011 180 mg QD combined with atilizumab 1200 mg q3w
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Elimination of CO2-insufflation-induced Hypercarbia in Open Heart Surgery
Status: UNKNOWN
Conditions: Adult Patients Undergoing Open Heart Replacement of the Aortic Valve for Aortic Stenosis or Insufficiency
Interventions: PROCEDURE: Tube clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CLA and Vitamin D on Protein Turnover
Status: COMPLETED
Conditions: Protein
Interventions: DIETARY_SUPPLEMENT: Conjugated linoleic acid|DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: Conjugated linoleic acid and Vitamin D|OTHER: Corn oil (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Border Region Area Lifestyle Intervention Study for Healthy Neurocognitive Ageing Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: diet|BEHAVIORAL: cognitive stimulation|BEHAVIORAL: physical activity|OTHER: risk factor management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Multiple Doses of CS-8080 in Healthy Volunteers
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: CS-8080|DRUG: placebo tablets|DRUG: CS-8080|DRUG: CS-8080
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Initiation of Cooling by EMS to Promote Adoption of In-hospital Hypothermia in Cardiac Arrest Survivors
Status: COMPLETED
Conditions: Out of Hospital Cardiac Arrest
Interventions: BEHAVIORAL: Pre-hospital cooling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Ursodiol, Combination Chemotherapy, and Bevacizumab in Treating Patients With Stage IV Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: FOLFOX regimen|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin|DRUG: ursodiol|GENETIC: RNA analysis|GENETIC: gene expression analysis|GENETIC: polymerase chain reaction|GENETIC: western blotting|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|OTHER: pharmacological study|PROCEDURE: positron emission tomography (PET)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Effects of rTMS on Excitability of the Quadriceps With Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: rTMS and exercise|DEVICE: Sham rTMS and exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate Efficacy and Safety of LIB003 and Inclisiran in High-risk CVD Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypercholesterolemia|Atherosclerotic Ischemic Disease
Interventions: BIOLOGICAL: lerodalcibep|DRUG: Inclisiran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1-2 Dose-Escalation and Cohort-Expansion Study of Oral Tomivosertib (eFT-508) in Subjects With Hematological Malignancies
Status: TERMINATED
Conditions: Lymphoma
Interventions: DRUG: Tomivosertib (eFT-508)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Wear Experience With Daily Disposable and Monthly Replacement Toric Contact Lenses
Status: COMPLETED
Conditions: Astigmatism Bilateral
Interventions: DEVICE: Daily disposable toric soft contact lens|DEVICE: Monthly replacement toric daily wear soft contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: MLC901 for Moderate to Severe Traumatic Brain Injury (Specified Drug Code)
Status: UNKNOWN
Conditions: Traumatic Brain Injury
Interventions: DRUG: MLC901 or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effects of Gastric pH on the Pharmacokinetics of Atazanavir
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ritonavir-boosted Atazanavir|DRUG: Ritonavir-boosted Atazanavir plus Rabeprazole|DRUG: Ritonavir-boosted Atazanavir plus Rabeprazole AND Betaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of a Novel Food Product Containing Microbiota Accessible Carbohydrates on the Human Microbiome
Status: COMPLETED
Conditions: Gut Microbiome
Interventions: DIETARY_SUPPLEMENT: Dietary MACs|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Chimeric Antigen Receptor T-Cell (CAR-T) Cells in Patients With R/R T-LBL
Status: UNKNOWN
Conditions: T Cell Lymphoblastic Lymphoma
Interventions: BIOLOGICAL: BT-007 CD7 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fifty Two Week Extension Trial of Org 50081 (Esmirtazapine) in the Treatment of Insomnia (P05708)
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: Org 50081
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Happy Hands - an E-self-management Intervention for People With Hand Osteoarthritis
Status: COMPLETED
Conditions: Hand Osteoarthritis
Interventions: OTHER: e-self-management intervention (Happy Hands app)|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Dental Pain Study Comparing The Analgesic Efficacy Of Ibuprofen/Caffeine
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Ibuprofen/Caffeine|DRUG: Ibuprofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Effects of KN056 in Healthy Participants
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: KN056 (0.1mg)|DRUG: KN056 (0.3mg)|DRUG: KN056 (1.0mg)|DRUG: KN056 (3.0mg)|DRUG: KN056 (6.0mg)|DRUG: KN056 (12.0mg)|DRUG: KN056 (18.0mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extended Letrozole Regimen Versus Clomiphene Citrate for Superovulation in Patients With Unexplained Infertility Undergoing Intrauterine Insemination
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Extended letrozole regimen|DRUG: Clomiphene citrate regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Colonic Microbiome and Mucosal Immunity in Inflammatory Bowel Disease and Ankylosing Spondylitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Inflammatory Bowel Diseases (IBD)|Ankylosing Spondylitis (AS)
Interventions: PROCEDURE: Pinch biopsies|PROCEDURE: Flexible sigmoidoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of EDP1815 in the Treatment of Patients Hospitalized With COVID-19 Infection
Status: TERMINATED
Conditions: Covid19
Interventions: DRUG: EDP1815|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Comparison of the Methods Applied in Bariatric Surgery in Terms of Preoxygenation Time
Status: COMPLETED
Conditions: Time to Reach 90% Endtidal Oxygen During Preoxygenation
Interventions: OTHER: CPAP preoxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Preterm Infants Fed a Human Milk Fortifier
Status: NOT_YET_RECRUITING
Conditions: Growth
Interventions: OTHER: Control Product|OTHER: Experimental Product 1|OTHER: Experimental Product 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Kinesio Taping on Pain, Posture and Function in Lower Cross Syndrome
Status: RECRUITING
Conditions: Lower Cross Syndrome
Interventions: OTHER: Kinesio taping|OTHER: Conventional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effectiveness of the Personal Pap Smear Device™ for Collection of Cervical Cells
Status: NOT_YET_RECRUITING
Conditions: Cervical Cancer Screening
Interventions: DEVICE: Pap smear collection using the Personal Pap Smear (PPS) Device|DEVICE: Active Comparator: Pap smear collection using the Rovers Cervex-Brush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Avoiding Anticoagulation After IntraCerebral Haemorrhage
Status: RECRUITING
Conditions: Intracerebral Hemorrhage|Atrial Fibrillation|Microhaemorrhage
Interventions: DRUG: Apixaban 5 MG|DEVICE: left atrial appendage closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Ticagrelor Versus Clopidogrel on Residual Thrombus Burden During PCI: an OCT Study
Status: WITHDRAWN
Conditions: Acute Coronary Syndrome|Coronary Artery Disease
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel|DEVICE: Optical Coherence Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: The Effect of Press Needle in the Combination of Ear and Body Acupuncture Points on Visual Analog Scale in Post-Operative Patients of Open Spine Surgery
Status: RECRUITING
Conditions: Post-operative Pain|Spine, Open
Interventions: DEVICE: Press needle|DEVICE: Sham press needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quality Improvement in Infection COntrol and Sepsis Management in MOdel Regions
Status: COMPLETED
Conditions: Sepsis|Severe Sepsis|Septic Shock
Interventions: OTHER: structured case analysis|OTHER: strucured screening "every patient, every shift"
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effectiveness of Ritonavir Plus Zidovudine Plus Lamivudine in HIV-Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Ritonavir|DRUG: Lamivudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Phase 2 Trial of TD-6424 (Telavancin) Versus Standard Therapy for Complicated Gram Positive Skin and Skin Structure Infections (Gram Positive cSSSI)
Status: COMPLETED
Conditions: Infections, Gram-positive Bacterial
Interventions: DRUG: Telavancin|DRUG: vancomycin or antistaphylococcal penicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modeling and Application of Triple Drug Response Surface Models
Status: COMPLETED
Conditions: Pharmacodynamics|Drug Interactions
Interventions: DRUG: Fentanyl|OTHER: Bispectral index (BIS) and analgesia nociception index (ANI)|DRUG: alfentanil|DRUG: Propofol|DRUG: sevoflurane|DRUG: midazolam
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: High-Intensity Focused Ultrasound Ablation in Treating Patients With Progressive Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: OTHER: pharmacological study|OTHER: questionnaire administration|PROCEDURE: assessment of therapy complications|PROCEDURE: high-intensity focused ultrasound ablation|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy(Immunogenicity) of GC3111 in Healthy Adults
Status: UNKNOWN
Conditions: Tetanus|Diphtheria|Whooping Cough
Interventions: BIOLOGICAL: GC3111 vaccine|BIOLOGICAL: Boostrix® vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Allogenic Umbilical Cord Blood-derived Mesenchymal Stem Cell Product
Status: UNKNOWN
Conditions: Osteochondral Lesion of Talus
Interventions: BIOLOGICAL: Cartistem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Randomized Control Trial Comparing Two Drug Combinations for Pain Management After Third Molars Surgery
Status: SUSPENDED
Conditions: Impacted Third Molar Tooth|PAIN
Interventions: DRUG: diclofenac / acetaminophen /codeine|DRUG: ibuprofen/acetaminophen/codeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Capecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients with Leptomeningeal Disease
Status: RECRUITING
Conditions: Leptomeningeal Metastasis|Leptomeningeal Disease|HER2-positive Metastatic Breast Cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Brief Behavioral Treatment of Insomnia (BBTI) for Sleep Intervention (SI)
Status: COMPLETED
Conditions: Insomnia|Depression|Posttraumatic Stress Disorder|Suicidal Ideation
Interventions: BEHAVIORAL: CBT-I|OTHER: TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Absorption, Metabolism, and Excretion of Orally Administered [14C]-BMS-986368 in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: [14C]-BMS-986368
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medication Histories Conducted by Nurses (RNs), Pharmacy Techs (CPhTs) & Pharmacists (RPhs)
Status: TERMINATED
Conditions: Medication Reconciliation|Emergency Department
Interventions: OTHER: Medication reconciliation completed by a RN, CPhT, or RPh
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Durvalumab/Tremelimumab in Neoadjuvant and Adjuvant Setting in Patients With HCC Treated by Electroporation Ablation
Status: RECRUITING
Conditions: BCLC A Hepatocellular Carcinoma Non-resectable and Not Amenable for RFA
Interventions: DRUG: Durvalumab/Tremelimumab in neoadjuvant and Durvalumab in adjuvant setting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Color Synbiotics Study
Status: COMPLETED
Conditions: Beneficial Bacteria in Gut
Interventions: OTHER: Regular non-hydrolysed cow's milk I|OTHER: Regular non-hydrolysed cow's milk II|OTHER: Regular non-hydrolysed cow's milk - control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effect of Dietary Fiber on Metabolism, Inflammation and Nutritional Status in Patients With Chronic Diseases
Status: UNKNOWN
Conditions: Chronic Disease|Dietary Fiber
Interventions: DIETARY_SUPPLEMENT: Nutrition Management and Dietary Fiber|DIETARY_SUPPLEMENT: Nutrition Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Rimonabant on Weight Loss and Frequency of Binge Episodes in Obese Patients
Status: COMPLETED
Conditions: Obesity|Eating Disorders
Interventions: DRUG: rimonabant (SR141716)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Acceptability of Mindful Self-Compassion Among Transgender and Nonbinary Young Adults
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: BEHAVIORAL: Mindful Self-Compassion (MSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate Adverse Events and Change in Disease Activity With Oral Tablets of Upadacitinib in Adult Participants With Non-Segmental Vitiligo
Status: COMPLETED
Conditions: Non-Segmental Vitiligo
Interventions: DRUG: Upadacitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validity of Korebalance Balance System
Status: UNKNOWN
Conditions: Osteoporosis, Postmenopausal|Balance; Distorted
Interventions: DIAGNOSTIC_TEST: Berg Balance Scale|DIAGNOSTIC_TEST: Timed Up and Go Test|DIAGNOSTIC_TEST: Korebalance Balance System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Subcutaneous Risankizumab Injection Compared to Oral Apremilast Tablets to Assess Change in Disease Activity And Adverse Events in Adult Participants With Moderate Plaque Psoriasis Who Are Candidates for Systemic Therapy
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Risankizumab|DRUG: Apremilast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetes Remission After RYGBP and RYGBP With Fundus Resection
Status: COMPLETED
Conditions: Type 2 Diabetes|Morbid Obesity|Bariatric Surgery
Interventions: PROCEDURE: Laparoscopic Roux en Y gastric bypass|PROCEDURE: Laparoscopic Roux en Y gastric bypass with fundus resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Add-on Mirabegron in Pediatric Patients With Refractory Overactive Bladder
Status: COMPLETED
Conditions: Overactive Bladder|Urinary Incontinence
Interventions: DRUG: Mirabegron
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy, Safety and Anti-Inflammatory Effect Between Topical 0.05%Cyclosporine A Emulsion and REFRESH® in Patients With Moderate to Severe Dry Eyes
Status: UNKNOWN
Conditions: Dry Eye
Interventions: DRUG: 0.05% cyclosporin eye drop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antiepileptic Efficacy Study of GWP42003-P in Children and Young Adults With Dravet Syndrome (GWPCARE1)
Status: COMPLETED
Conditions: Epilepsy|Dravet Syndrome
Interventions: DRUG: GWP42003-P 20 mg/kg/day Dose|DRUG: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Pharmacokinetic Properties of 9MW3811 in Healthy Subjects
Status: RECRUITING
Conditions: Pulmonary Fibrosis|Tumor
Interventions: DRUG: 9MW3811 injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety, Pharmacodynamics, Efficacy, and PK of TIMP-GLIA in Subjects With Celiac Disease
Status: COMPLETED
Conditions: Celiac Disease
Interventions: DRUG: TIMP-GLIA|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing SonoVue With Sonazoid Using CEUS-LIRADS in HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma|Cirrhosis
Interventions: DRUG: Sonovue and Sonazoid|DRUG: Sonazoid and Sonovue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Effect of Narrowband UVB Versus Methotrexate on Serum Chitotriosidase Level in Psoriasis
Status: UNKNOWN
Conditions: Psoriasis
Interventions: RADIATION: Narrowband ultraviolet B|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Curcumin for HPV Related Cervical Disease
Status: NOT_YET_RECRUITING
Conditions: Neoplasm Cervix
Interventions: DRUG: Curcumin C3 Complex|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BES, EES, and ZES-R in Real World Practice
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Biolimus-eluting stent|DEVICE: Everolimus-eluting stent|DEVICE: Zotarolimus-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Place of Comprehensive Geriatric Assessment in Patients ≥ 75 Years Care, With Breast Cancer, After Screening With FOG (Oncology Geriatric Filter)
Status: ACTIVE_NOT_RECRUITING
Conditions: Surgery|75 Years Old and More|Female Breast Cancer
Interventions: BEHAVIORAL: Medical consultation for a Standardized Geriatric Evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Incidence of Acute Laryngeal Injury Following Endotracheal Intubation
Status: RECRUITING
Conditions: Intubation Complication
Interventions: DRUG: Budesonide and Azithromycin|OTHER: Placebo control of budesonide and azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Multi-dimensional Prospective Study to Discover Gene-microenvironment Interactions in Neurodevelopmental Disorders
Status: RECRUITING
Conditions: Attention-Deficit Hyperactivity Disorder, Unspecified Type|Autism Spectrum Disorder
Interventions: OTHER: ASD diagnosis|OTHER: Psychiatric diagnosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Co-induction Ketamine-propofol: Effects on Laryngeal Mask Airway Insertion Conditions in Children
Status: COMPLETED
Conditions: Anesthesia Intubation Complication
Interventions: DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Baby Friendly Spaces in Cox's Bazar, Bangladesh.
Status: UNKNOWN
Conditions: Psychosocial Functioning|Psychological Distress
Interventions: BEHAVIORAL: Baby Friendly Spaces (BFS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy Study of IV Fluids Only vs Ondansetron to Treat Dehydration
Status: WITHDRAWN
Conditions: Dehydration|Gastroenteritis
Interventions: DRUG: Ondansetron|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of CEA-targeted CAR-T Therapy for CEA-positive Advanced Malignant Solid Tumors
Status: RECRUITING
Conditions: Colorectal Cancer|Esophageal Cancer|Stomach Cancer|Pancreatic Cancer|Metastatic Tumor|Recurrent Cancer
Interventions: BIOLOGICAL: CEA CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Early Harvest Olive Oil in Cognition of Primary (PPMS) or Secondary (SPMS) Progressive Multiple Sclerosis
Status: COMPLETED
Conditions: Progressive Multiple Sclerosis
Interventions: DIETARY_SUPPLEMENT: Early Harvest Extra Virgin Olive Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Increased Ketorolac Administration After Cesarean Section and Its Effect on Opioid Use: a Randomized Control Trial
Status: COMPLETED
Conditions: Post-operative Pain|Post-partum Pain|Cesarean Section Complications
Interventions: DRUG: Ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Hydrochloride With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Brenner Tumor|Ovarian Carcinosarcoma|Ovarian Clear Cell Cystadenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Mucinous Cystadenocarcinoma|Ovarian Seromucinous Carcinoma|Ovarian Serous Cystadenocarcinoma|Ovarian Serous Surface Papillary Adenocarcinoma|Ovarian Undifferentiated Carcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma
Interventions: DRUG: Adavosertib|DRUG: Gemcitabine Hydrochloride|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|OTHER: Placebo Administration|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT