pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Intervention by a Cardiologist and Geriatrician in Elderly Patients After Admission Due to Heart Failure.
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: Ambulatory visit|OTHER: Combined ambulatory visit|OTHER: Geriatric intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clini Asses of Retentn,Pt Satisfactn and Recurrent Caries of Endocrs Versus Post Crs Using Reinforced Lithium Silicate
Status: UNKNOWN
Conditions: Endodontically Treated Teeth
Interventions: OTHER: Reinforced lithium silicate endocrowns|OTHER: Post retained reinforced lith silicate crn
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Motivational Interviewing for Long-term Sick Absence
Status: COMPLETED
Conditions: Sick Leave
Interventions: BEHAVIORAL: Treatment as usual (TAU-0)|BEHAVIORAL: Structured talks (TAU-2)|BEHAVIORAL: motivational interviewing (MI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bismuth Improves the Efficacy of Levofloxacin-containing Triple Therapy for Helicobacter Pylori Treatment
Status: COMPLETED
Conditions: Functional Dyspepsia|Peptic Ulcer
Interventions: DRUG: Bismuth|DRUG: Lansoprazole|DRUG: Levoﬂoxacin|DRUG: Amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of LY3039478 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3039478|DRUG: 3C 15N 2H-LY3039478 IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Thumb and Wrist Proprioception Exercises.
Status: UNKNOWN
Conditions: Radius Fractures|Hand Injuries|Pain, Chronic|Proprioceptive Disorders
Interventions: OTHER: Thumb active Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mitomycin C Versus Bacillus Calmette-Guerin in the Intravesical Treatment of Non-Muscle-Invasive Bladder Cancer Patients
Status: TERMINATED
Conditions: Bladder Cancer
Interventions: DRUG: Mitomycin C (MMC)|BIOLOGICAL: Bacillus Calmette-Guerin (BCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relapsed or Refractory Primary Diffuse Large B-cell Lymphoma (DLBCL) of the Central Nervous System (CNS)
Status: RECRUITING
Conditions: DLBCL
Interventions: DRUG: Tislelizumab|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Nab-paclitaxel in Patients With Desmoid Tumors and Multiply Relapsed/Refractory Desmoplastic Small Round Cell Tumors and Ewing Sarcoma
Status: COMPLETED
Conditions: Tumor, Desmoplastic Small Round Cell, Adult|Tumor, Desmoplastic Small Round Cell, Childhood|Sarcoma, Ewing|Sarcoma|Desmoid
Interventions: DRUG: nab paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Milademetan Administration on Cardiac Repolarization in Healthy Subjects
Status: TERMINATED
Conditions: Cardiac Repolarization
Interventions: DRUG: Placebo|DRUG: Moxifloxacin (positive control)|DRUG: Milademetan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Pain Relieving Effect of Dronabinol in Central Neuropathic Pain Related to Multiple Sclerosis
Status: COMPLETED
Conditions: Central Neuropathic Pain in Multiple Sclerosis
Interventions: DRUG: Dronabinol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of INCB160058 When Administered Orally to Healthy Adult Participant
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: INCB160058|DRUG: Placebo|DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A New Training to Enhance Physical Activity in Adolescents With Cerebral Palsy
Status: RECRUITING
Conditions: Cerebral Palsy|Muscle Disorder|Physical Disability|Posture Disorders in Children|Spina Bifida
Interventions: OTHER: Loaded high intensity training|OTHER: High intensity circuit training (HICT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Changes in Pelvic Health, Sexual Function, and Quality of Life in Women With Pelvic Cancer Undergoing Radiation Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Anal Carcinoma|Cervical Carcinoma|Endometrial Carcinoma|Malignant Pelvic Neoplasm|Rectal Carcinoma|Vaginal Carcinoma|Vulvar Carcinoma
Interventions: PROCEDURE: Pelvic Examination|OTHER: Survey
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Personalized Therapy Study - Intrinsic Antitachycardia Pacing Post-Approval Study (iATP PAS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Ventricular Tachycardia
Interventions: DEVICE: Intrinsic Antitachycardia Pacing (iATP) Therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: New Antipsychotic Strategies: Quetiapine and Risperidone vs. Fluphenazine in Treatment Resistant Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Quetiapine, Risperidone, Fluphenazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Polyglactin 910 vs Poligelecaprone 25 Running Subcuticular Closure of Elliptical Excision Wounds
Status: WITHDRAWN
Conditions: Cosmetics, Suture, Cicatrix
Interventions: PROCEDURE: running subcuticular closure of excisional defect
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Positive Pressure (NPPV ) for Severe Stable Chronic Obstructive Pulmonary Disease
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease|Hypercapnic Respiratory Failure
Interventions: DEVICE: BiPAP mode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prolonged Fasting on Glucose Metabolism and Hormonal Regulation in Healthy, Obese and Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Healthy|Obesity|Type 2 Diabetes Mellitus|Type 1 Diabetes
Interventions: BEHAVIORAL: 12h fasting|BEHAVIORAL: 36h fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation Of One Silicone Hydrogel Contact Lens and Two Hydrogel Lenses in Daily Wear
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: fanfilcon A test lens|DEVICE: ocufilcon D control lens|DEVICE: etafilcon A control lens
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Heart Exercise And Resistance Training - Peer Lead ActivitY
Status: UNKNOWN
Conditions: Cardiovascular Diseases
Interventions: BEHAVIORAL: HEART-PLAY|BEHAVIORAL: Standard Cardiac Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TIL Cells for the Treatment of the Advanced Solid Tumors Patients
Status: NOT_YET_RECRUITING
Conditions: Solid Tumor
Interventions: BIOLOGICAL: Tumor Infiltrating Lymphocytes|DRUG: Fludarabine|DRUG: Cyclophosphamide Capsules|DRUG: IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Argon Plasma Coagulation and Clip for the Prophylaxis of Post-polypectomy Bleeding After Hot Snare Polypectomy
Status: UNKNOWN
Conditions: Post-polypectomy Bleeding|Colorectal Polyp
Interventions: PROCEDURE: argon plasma coagulation|PROCEDURE: clip closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety and Tolerability of TOS-358 in Adults With Select Solid Tumors
Status: RECRUITING
Conditions: Colorectal Cancer|Gastric Cancer|HER2-negative Breast Cancer|Non-small Cell Lung Cancer|Squamous Cell Carcinoma of Head and Neck|Urothelial Carcinoma|Cervical Cancer|Ovarian Cancer|Endometrial Cancer
Interventions: DRUG: TOS-358
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SIB in Upper Thoracic Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: RADIATION: Simultaneous integrated boost intensity-modulated chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Randomized, Open-label, Parallel-controlled, Pharmacokinetic and Safety Study of BR201 Injection Versus Cosentyx in Healthy Male Subjects
Status: NOT_YET_RECRUITING
Conditions: Psoriasis
Interventions: DRUG: BR201|DRUG: Cosentyx（Secukinumab ）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Frozen-thawed Embryo Transfer (FTET) Cycle Follow-up Protocol (P06031)
Status: COMPLETED
Conditions: Infertility
Interventions: BIOLOGICAL: Corifollitropin alfa|BIOLOGICAL: recFSH (follitropin beta)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Remote Ischaemic Preconditioning in Cemented Hip Arthroplasty.
Status: RECRUITING
Conditions: Osteoarthritis, Hip|Cardiovascular Diseases|Bone Cement Implantation Syndrome|Kidney Diseases
Interventions: PROCEDURE: Remote Ischemic Preconditioning|OTHER: SHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hypogonadism in Young Men With Type 2 Diabetes
Status: TERMINATED
Conditions: Hypogonadotropic Hypogonadism|Type 2 Diabetes
Interventions: DRUG: testosterone|DRUG: clomiphene|DRUG: placebo|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Awakening Versus Bedtime Dosing of Aspirin in Pre-Hypertension or Mild Essential Hypertension
Status: TERMINATED
Conditions: High-Normal Blood Pressure|Mild Essential Hypertension
Interventions: DRUG: Aspirin 100 mg|DEVICE: Ambulatory blood pressure monitoring|PROCEDURE: Chronotherapy, timing of medication|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Detection and Quant of Differences in Hodgkin Lymphoma and Diffuse Large B-cell Lymphoma Using Positron Emission Tomography/Computed Tomography (PET/CT)
Status: COMPLETED
Conditions: Lymphoma
Interventions: RADIATION: Fludeoxyglucose F18|PROCEDURE: Computed Tomography|PROCEDURE: Positron emission tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cross-over Study of Coronary Risk Factors With a Polypill
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DRUG: Polypill of acetylsalicylic acid, ramipril and atorvastatin|DRUG: Drugs taken separately: acetylsalicylic acid, ramipril and atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Lu AG06466 in Participants With Treatment Resistant Focal Epilepsy
Status: TERMINATED
Conditions: Focal Epilepsy
Interventions: DRUG: Lu AG06466|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of JKB-122 on Prednisolone and Azathioprine Induced Remission in Autoimmune Hepatitis (AIH)
Status: UNKNOWN
Conditions: Autoimmune Hepatitis
Interventions: DRUG: JKB-122|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dapagliflozin in Non-Diabetic Patients With Nephrotic Syndrome.
Status: NOT_YET_RECRUITING
Conditions: Nephrotic Syndrome
Interventions: DRUG: Dapagliflozin and Standard therapy (ACEI or ARB).|DRUG: Standard Therapy (ACEI or ARB).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of the Safety and Clinical Utility of Handheld ECG Technology in Psychiatry
Status: UNKNOWN
Conditions: Cardiovascular Diseases|Dementia|Mental Health Disorder
Interventions: DEVICE: 12 lead ECG monitoring|DEVICE: 6 lead ECG monitoring|DEVICE: Hand held ECG monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Turmeric for Patients With Basal Joint Arthritis
Status: RECRUITING
Conditions: Thumb Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: Turmeric|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Combined Use of Letrozole, Mifepristone and Misoprostol in Termination of Pregnancy
Status: UNKNOWN
Conditions: Complete Abortion
Interventions: DRUG: mifepristone|DRUG: Letrozole|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Different Ventilatory Strategies in Acute Respiratory Distress Syndrome Due to Community-acquired Pneumonia
Status: TERMINATED
Conditions: Community-acquired Pneumonia|Acute Respiratory Distress Syndrome
Interventions: PROCEDURE: Positive end-expiratory pressure titration with driving pressure control|PROCEDURE: ARDSNet ventilatory strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Four-week Breathing Interventions on Gut Symptoms, Heart Rate Variability, and Psychological Measures in Runners
Status: COMPLETED
Conditions: Gastrointestinal System--Abnormalities|Anxiety|Visceral Pain
Interventions: BEHAVIORAL: Slow deep breathing plus breath counting|BEHAVIORAL: Normal-paced breathing plus breath counting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Acupoint Application in Patients With Stable Angina Pectoris (AASAP)
Status: COMPLETED
Conditions: Stable Angina Pectoris
Interventions: DRUG: Herbal plaster ( styrax, borneol, frankincense, santalum,trichosanthes kirilowii Maxim, allium macrostemon Bunge, leech)|DEVICE: acupoint|DRUG: Aspirin: 100mg qd; Metoprolol：25mg bid; Ramipril:5mg qd; Atorvastatin:20mg qn.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Aldosterone Antagonist Therapy for Prevention of New Atrial Fibrillation
Status: ACTIVE_NOT_RECRUITING
Conditions: AFib
Interventions: DRUG: Spironolactone|DRUG: No Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity of Fractional One-fifth and One-half Doses of Yellow Fever Vaccine Compared to Full Dose in Children 9-23 Months Old
Status: UNKNOWN
Conditions: Yellow Fever
Interventions: BIOLOGICAL: Yellow Fever 17DD Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Satisfaction Comparing Two Braces in the Treatment of Developmental Dysplasia of the Hip (DDH) in Infants
Status: COMPLETED
Conditions: Hip Dislocation, Congenital|Congenital Deformity of Hip Joint
Interventions: OTHER: Pavlik Brace|OTHER: Plastizote Brace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effectiveness of Telepsychiatry for Treating Major Depression in a Chinese American Nursing Home
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Psychotropic medication (at discretion of psychiatrist)|BEHAVIORAL: Collaborative psychiatric and primary medical care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Absorption, Metabolism, and Excretion of [14C]-E6007 After a Single Oral Administration in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy Male Participants
Interventions: DRUG: [14C]-E6007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Central Line Catheterization With Flexible Tip Straight Guidewire in Small Children
Status: COMPLETED
Conditions: Catheterization, Central Venous
Interventions: DEVICE: Flexible tip straight guidewire|DEVICE: J-tip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neoadjuvant Study of Palbociclib in Combination With Letrozole and Trastuzumab in Stage II-III ER+ HER2+ Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer|Cancer of Breast|Breast Carcinoma
Interventions: DRUG: Palbociclib|DRUG: Letrozole|BIOLOGICAL: Trastuzumab|DRUG: Goserelin|PROCEDURE: Breast surgery|PROCEDURE: Research tumor biopsy|PROCEDURE: Research bone marrow (OPTIONAL)|PROCEDURE: Research blood sample|GENETIC: Research blood for germline DNA|PROCEDURE: Blood for detection of circulating tumor cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRI to Assess Fibrosis in Eosinophilic Esophagitis Patients
Status: TERMINATED
Conditions: Eosinophilic Esophagitis
Interventions: DIAGNOSTIC_TEST: MRI to detect inflammation and fibrosis in subjects with EoE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Initiation of Ovarian Stimulation With Recombinant-human FSH (Bemfola®) in the Late Follicular Phase
Status: COMPLETED
Conditions: Infertility, Female
Interventions: COMBINATION_PRODUCT: Late follicular phase stimulation with recombinant-human FSH|COMBINATION_PRODUCT: Early follicular phase stimulation with recombinant-human FSH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changing Healthy Outcomes In Clinic Environments
Status: COMPLETED
Conditions: Obesity|Physical Inactivity|Diabetes
Interventions: BEHAVIORAL: One on one counseling|BEHAVIORAL: Group/team - based health education|BEHAVIORAL: PACE physician counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: EFFICACY and SAFETY OF BEVACIZUMAB (ZIRABEV®) IN PATIENTS WITH SEVERE HYPOXEMIC COVID-19
Status: COMPLETED
Conditions: Corona Virus Infection|SARS (Severe Acute Respiratory Syndrome)|Virus Diseases|Coronaviridae Infections|Nidovirales Infections|RNA Virus Infections|Respiratory Tract Infections|Respiratory Tract Diseases
Interventions: DRUG: BEVA+SOC|DRUG: SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Twice Daily Oral LNP023 in Adult PNH Patients With Residual Anemia Despite Anti-C5 Antibody Treatment
Status: COMPLETED
Conditions: Paroxysmal Nocturnal Hemoglobinuria (PNH)
Interventions: DRUG: LNP023|DRUG: Eculizumab|DRUG: Ravulizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a Pneumococcal Conjugate Vaccine in Adults Aged 50 to 84 Years.
Status: COMPLETED
Conditions: Pneumoccocal Immunisation
Interventions: BIOLOGICAL: Pneumococcal Conjugate Vaccine - formulation 1-SP0202-IIb|BIOLOGICAL: Pneumococcal Conjugate Vaccine - formulation 2-SP0202-VI|BIOLOGICAL: Pneumococcal Conjugate Vaccine - formulation 3-SP0202-VII|BIOLOGICAL: Pneumococcal 13 - valent conjugate vaccine-Prevnar 13|BIOLOGICAL: Pneumococcal Vaccine Polyvalent-Pneumovax 23
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Mechanisms of Diameter Changes in Retinal Vessels During Hypoxia
Status: COMPLETED
Conditions: Retinal Hypoxia
Interventions: DRUG: COX-inhibitor|DRUG: Nitroglycerin|DRUG: COX-inhibitor + Nitroglycerin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Community Based Management of Fast Breathing in Infants Aged < 60 Days in Low-income Settlements of Karachi
Status: TERMINATED
Conditions: Fast Breathing in Young Infants
Interventions: DRUG: Amoxicillin|DRUG: Sugar Syrup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Osimertinib in Patients With Stage 4 Non-small Cell Lung Cancer With Uncommon EGFR Mutations
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prednisolone in Early Diffuse Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis
Interventions: DRUG: Prednisolone 5 mg|DRUG: Placebo oral capsule; From August 2020 'no additional treatment'
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Demonstrate Bioequivalence Between Insulin Glulisine U300 and Insulin Glulisine U100 After a Single Subcutaneous Dose Using the Euglycemic Clamp Technique, in Patients With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type1 Diabetes Mellitus
Interventions: DRUG: Insulin glulisine (U300)|DRUG: Insulin glulisine|DRUG: Insulin aspart|DRUG: NPH insulin|DRUG: Glucagon|DRUG: Glucose|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aggressive Antipyretics for Fever Reduction in CNS Malaria
Status: COMPLETED
Conditions: Malaria|Seizures|Coma|Parasitemia|Hyperpyrexia|Fever
Interventions: DRUG: Acetaminophen|DRUG: Ibuprofen|DRUG: placebo for acetaminophen|DRUG: placebo for ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Two Preventive Regimens for Latent Tuberculosis Infection (LTBI)
Status: UNKNOWN
Conditions: Latent Tuberculosis Infection
Interventions: DRUG: 4-month rifampin vs. 9-month isoniazid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Observe Safety of Xarelto in VTE Prophlylaxis After Elective TKR (Total Knee Replacement) or THR (Total Hip Replacement)
Status: WITHDRAWN
Conditions: Prophylaxis, Thromboembolism, Venous|Total Knee Replacement|Total Hip Replacement
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Rivaroxaban Versus Aspirin for Non-disabling Cerebrovascular Events
Status: UNKNOWN
Conditions: Ischemic Stroke|TIA
Interventions: DRUG: rivaroxaban|DRUG: Aspirin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: French Digestive Polyposis Cohorte Family Adenomatous Polyposis With APC and MYH Gene Mutations , Cowden's Disease With PTEN Gene Mutation, Peutz Jeghers Disease With STK 11 Gene Mutation ,juvénil Polyposis With SMAD 4 Gene Mutation , Serrated and Hyperplastic Polyposis
Status: UNKNOWN
Conditions: Quality of Life
Interventions: OTHER: Procedure surgery behavioral and genetic diagnosis|PROCEDURE: quality of life after different type of surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess Radiation Induced Mucositis in Patients of Head and Neck Cancer Administered Chemo-Radiation With or Without P276-00
Status: COMPLETED
Conditions: Radiation Induced Mucositis in Head and Neck Cancer
Interventions: DRUG: P276-00|RADIATION: Radiation Therapy|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: How Effective Are Antithrombotic Therapies in Primary Percutaneous Coronary Intervention
Status: COMPLETED
Conditions: Acute ST Elevation Myocardial Infarction
Interventions: DRUG: unfractionated heparin|DRUG: Bivalirudin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FAST Fish Phase IIb Clinical Trial for the Treatment of Fish Allergy by Subcutaneous Immunotherapy
Status: COMPLETED
Conditions: Food Allergy to Fish
Interventions: BIOLOGICAL: FAST fish mCyp c 1|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Texas Hepatocellular Carcinoma Consortium (THCCC) Project 5
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular|Liver Neoplasms
Interventions: BEHAVIORAL: Outreach with patient education and patient navigation services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: Study of OXB-102 (AXO-Lenti-PD) in Patients With Bilateral, Idiopathic Parkinson's Disease
Status: TERMINATED
Conditions: Parkinson Disease
Interventions: DRUG: OXB-102|OTHER: Imitation Surgical Procedure (ISP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Long-Term Efficacy of Bempedoic Acid (ETC-1002) in Patients With Hyperlipidemia at High Cardiovascular Risk
Status: COMPLETED
Conditions: Hypercholesterolemia|Atherosclerotic Cardiovascular Disease
Interventions: DRUG: bempedoic acid|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Late Gestational Diabetes Mellitus Diagnosis in Obese Women
Status: NOT_YET_RECRUITING
Conditions: Gestational Diabetes Mellitus in Pregnancy|Macrosomia, Fetal|Dystocia, Shoulder|Neonatal Jaundice|Polycythemia|Hypoglycemia Neonatal|Obesity|Obesity, Morbid
Interventions: DIAGNOSTIC_TEST: oral glucose tolerance test (OGTT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Low-dose Pentavalent Antimony Treatment of Cutaneous Leishmaniasis in Old Age Patients
Status: COMPLETED
Conditions: Localized Cutaneous Leishmaniasis
Interventions: DRUG: Meglumine antimoniate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ARCHIPELAGO: Irbesartan in Patients With Acute Coronary Syndrome Without ST Segment Elevation
Status: COMPLETED
Conditions: Myocardial Ischemia|Hypertension
Interventions: DRUG: Irbesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Diagnostic Potential of Tear Proteins in Cancer - A Pilot Study
Status: ENROLLING_BY_INVITATION
Conditions: Breast Cancer|Ovarian Cancer|Pancreatic Cancer|Prostate Cancer|Melanoma
Interventions: OTHER: Schirmer strip, a Class I Medical Device typically used to test for dry eye.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Nitrate Supplement on the Oral Microbiome and Saliva in Dental Erosion
Status: ENROLLING_BY_INVITATION
Conditions: Dental Erosion
Interventions: DIETARY_SUPPLEMENT: Nitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Antiviral Activity of Entecavir in Patients Receiving Liver Transplant Due to Chronic Hepatitis B Virus Infection
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Herceptin (Trastuzumab) in Combination With Xeloda (Capecitabine) in Patients With Metastatic or Recurrent HER2-positive Breast Cancer After First-Line or (Neo)Adjuvant Therapy.
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: capecitabine [Xeloda]|DRUG: trastuzumab [Herceptin]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Randomized, Double-blind, Placebo-controlled Study of Sorafenib or Placebo in Combination With Transarterial Chemoembolization (TACE) Performed With DC Bead and Doxorubicin for Intermediate Stage Hepatocellular Carcinoma (HCC).
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Sorafenib (Nexavar, BAY43-9006)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Rifaximin With Xifaxan 200 mg in Traveler's Diarrhea
Status: COMPLETED
Conditions: Diarrhea
Interventions: DRUG: Rifaximin|DRUG: Xifaxan®|DRUG: Placebo Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Modification and Liraglutide
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: CMS-recommended lifestyle counseling|DRUG: Liraglutide 3.0mg|OTHER: Portion-Controlled Diet|DRUG: Placebo Oral Tablet|DRUG: Phentermine 15 MG|BEHAVIORAL: Extension Study CMS-recommended lifestyle counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Community Interventions in Non-medical Settings to Increase Informed Decision Making for Prostate Cancer Screening
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BEHAVIORAL: Educational Intervention to Increase Informed Decision Making for Prostate Cancer Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Rhodiola Rosea Therapy of Major Depressive Disorder
Status: COMPLETED
Conditions: Depression
Interventions: DIETARY_SUPPLEMENT: Herbal extract|DRUG: Sertraline|OTHER: Lactose monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical, Electrophysiological and E-field Modelling Evidence of High Density Transcranial Direct Current Stimulation in Motor Stroke
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: high definition transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Individual Effect of Diet on Postprandial Glycemia and Gut Microbiome Profile in Healthy Subjects
Status: NOT_YET_RECRUITING
Conditions: Glucose Metabolism Disorders|Health Behavior|Diabetes|Metabolic Disease
Interventions: OTHER: Standardized breakfast A|OTHER: Standardized breakfast B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of a Procalcitonin Testing and Treatment Algorithm on Antibiotic Use and Outcomes in the Pediatric Intensive Care Unit
Status: COMPLETED
Conditions: Sepsis|Procalcitonin|Antimicrobial Stewardship
Interventions: OTHER: Procalcitonin-Guided Antimicrobial Stewardship|OTHER: Baseline Antimicrobial Stewardship
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Address Precision and Refractive Predictability of Femtosecond Laser-assisted Astigmatic Keratotomy Following the Cataract Surgery
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: arcuate incision
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transmuscular Quadratus Lumborum Block for Laparoscopic Cholecystectomy
Status: WITHDRAWN
Conditions: Cholecystitis|Pain
Interventions: DRUG: Ropivacaine|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Diabetes in Patients With Systolic Heart Failure
Status: COMPLETED
Conditions: Heart Failure, Systolic|Diabetes Mellitus, Type 2
Interventions: DRUG: Canagliflozin|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of TENS and Interference on Pain, Functional Status and Range of Motion in Shoulder Pain in Stroke Patients
Status: COMPLETED
Conditions: Hemiplegic Shoulder Pain
Interventions: OTHER: TENS|OTHER: shamTENS|OTHER: IFC|OTHER: shamIFC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ketamine Infusion in Neurologic Deficit
Status: COMPLETED
Conditions: Subarachnoid Hemorrhage
Interventions: DRUG: Ketamine|DRUG: 0.9% NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of PET Imaging With 18F-TFB in Patients With Thyroid Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Thyroid Cancer
Interventions: PROCEDURE: PET Imaging|OTHER: 18F-tetrafluoroborate (18F-TFB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dietary Optimization of Microbiome Recovery Following Fecal Microbiota Transplantation
Status: RECRUITING
Conditions: Recurrent Clostridium Difficile Infection|Fecal Microbiota Transplant
Interventions: DIETARY_SUPPLEMENT: MEND diet|DIETARY_SUPPLEMENT: mNICE diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Does Dapagliflozin Promote Favorable Health Benefits That Are Independent Of Weight Loss?
Status: TERMINATED
Conditions: Weight Loss
Interventions: DRUG: Dapagliflozin|DRUG: Placebo|BEHAVIORAL: Weight maintenance|BEHAVIORAL: Ad libitum dietary intake|BEHAVIORAL: Dietary restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Smoking and Vitamin D3 on the Levels of Human Cathelicidin Peptide LL-37
Status: COMPLETED
Conditions: Periodontitis
Interventions: OTHER: LL-37 levels in Gingival crevicular fluid|OTHER: Serum Vitamin D3 levels|OTHER: Clinical parameters
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Marketed Contact Lens Disinfectant Systems on Eyelid Tissues
Status: COMPLETED
Conditions: Contact Lens Care
Interventions: DEVICE: Hydrogen peroxide-based contact lens care system|DEVICE: PHMB-containing contact lens solution|DEVICE: Soft contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: MesoPher/Mitazalimab-combination Therapy in Metastatic Pancreatic Disease (REACtiVe-2 Trial)
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer
Interventions: BIOLOGICAL: MesoPher|BIOLOGICAL: Mitazalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Does Low Dose of Dexamethasone Enhance Analgesic Quality of Caudal Analgesia in Children Undergoing Orchiopexy?
Status: COMPLETED
Conditions: Patients With Cryptorchism Who Are Planning to Undergo Orchiopexy
Interventions: DRUG: High dose dexamethasone|DRUG: Low dose dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Open-Label Phase 1/2 Study to Assess the Safety, Efficacy and Dose of Study Drug UX003 Recombinant Human Beta-glucuronidase (rhGUS) Enzyme Replacement Therapy in Patients With Mucopolysaccharidosis Type 7 (MPS 7)
Status: COMPLETED
Conditions: Mucopolysaccharidosis Type 7
Interventions: DRUG: UX003
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azithromycin for Meibomian Gland Disease
Status: UNKNOWN
Conditions: Dry Eye|Neuropathic Eye Pain|Ocular Microbiome|Depression, Anxiety
Interventions: DRUG: Azithromycin Oral Product|DRUG: Placebo Oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of Regadenoson in Subjects Undergoing Stress Myocardial Perfusion Imaging (MPI) Using Multidetector Computed Tomography (MDCT) Compared to Single Photon Emission Computed Tomography (SPECT)
Status: COMPLETED
Conditions: Coronary Artery Disease (CAD)
Interventions: DRUG: regadenoson|RADIATION: technetium Tc99m sestamibi /technetium Tc99m tetrafosmin|RADIATION: Contrast|PROCEDURE: Single Photon Emission Computed Tomography|PROCEDURE: Multidetector Computed Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Corticosteroids in Postoperative Critically Ill Neonates With Low Cardiac Output Syndrome With Congenital Heart Disease
Status: COMPLETED
Conditions: Cardiac Output, Low
Interventions: DRUG: Hydrocortisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Anti-Hypertensive Efficacy of Hyzaar(R) In Patients With Mild To Moderate Essential Hypertension (0954A-323)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: MK0954A, hydrochlorothiazide (+) losartan potassium / Duration of Treatment: 12 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Limited Market Release - MotionSense Clinical Use Evaluation
Status: COMPLETED
Conditions: Knee Arthroplasty|Patient Engagement|Patient-Reported Outcome Measures (PROMs)
Interventions: DEVICE: MotionSense
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: High-Dose Cytarabine Plus Deoxycytidine in Treating With Acute Myelogenous Leukemia or Other Hematologic Malignancies
Status: COMPLETED
Conditions: Drug/Agent Toxicity by Tissue/Organ|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: cytarabine|DRUG: deoxycytidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of Lacosamide in Pediatric Patients With Epilepsy
Status: UNKNOWN
Conditions: Epilepsy
Interventions: DRUG: Lacosamide|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgical Access Combined With Systematically Administered Antibiotics in the Treatment of Peri-implantitis
Status: COMPLETED
Conditions: Peri-Implantitis
Interventions: PROCEDURE: Open flap debridement|OTHER: Er: YAG irradiation|DRUG: Metronidazole|DRUG: Amoxicillin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immune Response Assessment Study of Killed-whole HIV-1 Vaccine (SAV001-H) in Chronic HIV-1 Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: SAV001-H
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia
Status: COMPLETED
Conditions: Endotoxemia|Inflammation|Multi Organ Dysfunction Syndrome
Interventions: DRUG: C1-esterase inhibitor|DRUG: Endotoxin administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: TranQuill™ Sling Snoreplasty for Snoring and Mild Obstructive Sleep Apnea:
Status: COMPLETED
Conditions: Snoring|Obstructive Sleep Apnea
Interventions: PROCEDURE: Snoreplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Placebo Controlled, Double Blind, Randomised, 8-week Phase IIa Proof of Concept Study to Assess the Efficacy and Safety of AKR 202 in Patients With Osteoarthritis Pain
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: AKR 202|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Therapeutic Effect of HU Pulse Therapy for CML Patients
Status: UNKNOWN
Conditions: Leukemia, Chronic Myeloid
Interventions: DRUG: hydroxyurea|DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dendritic Cells Therapy Combined With Immunomodulatory Treatment in Multiple Sclerosis
Status: RECRUITING
Conditions: Relapsing-Remitting Multiple Sclerosis
Interventions: OTHER: Autologous peripheral blood differentiated adult tolerogenic dendritic cells expanded|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of an Experimental Chemotherapy Combination to Treat Hormone Refractory Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: docetaxel|DRUG: LY2181308 sodium|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nano-Pulse Stimulation (NPS) in Sebaceous Hyperplasia Optimization Study
Status: TERMINATED
Conditions: Sebaceous Hyperplasia|Skin Abnormalities|Skin Lesion
Interventions: DEVICE: Nano-Pulse Stimulation (NPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of Pyrotinib Versus Docetaxel in Patients With Advanced Non-squamous NSCLC Harboring a HER2 Exon 20 Mutation Who Failed Platinum Based Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-squamous NSCLC|HER2 Exon 20 Mutation
Interventions: DRUG: Pyrotinib|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Trastuzumab Emtansine in Combination With Atezolizumab or Placebo as a Treatment for Participants With Human Epidermal Growth Factor 2 (HER2)-Positive and Programmed Death-ligand 1 (PD-L1)-Positive Locally Advanced (LABC) or Metastatic Breast Cancer (MBC)
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Trastuzumab Emtansine|DRUG: Atezolizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT