pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study To antagOnize Plasminogen Activator Inhibitor-1 in Severe COVID-19
Status: SUSPENDED
Conditions: Covid19
Interventions: DRUG: TM5614|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Resynchronisation Therapy in Combination With Overdrive Pacing in the Treatment of Central Sleep Apnea in CHF
Status: COMPLETED
Conditions: Heart Failure|Central Sleep Apnea
Interventions: DEVICE: CRT + AOP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Radiographic Outcomes of CAD/CAM vs Conventionally Constructed Occlusal Splints in Patients With Temporomandibular Joint Disorders
Status: UNKNOWN
Conditions: Temporomandibular Disorder
Interventions: DEVICE: CAD/CAM splints
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MyGeneMyDiet Trial for Weight Management
Status: ACTIVE_NOT_RECRUITING
Conditions: Overweight and Obesity
Interventions: GENETIC: MyGeneMyDiet® Recommendations for Weight Management|OTHER: Usual Standard of Care for Weight Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Efficacy and Patient Satisfaction of Local Anaesthesia Versus Sedoanalgesia for Botox (R) Injection in the Urinary Bladder for the Treatment of Idiopathic Overactive Bladder
Status: ENROLLING_BY_INVITATION
Conditions: Overactive Bladder
Interventions: DRUG: intravesical botulinum toxin A injection unter local anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficiency of Thoracolumbar Interfascial Plane Block in Lumbar Disk Surgery
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Bupivacaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Different Induction Protocols in PCOS After Clomiphene Citrate Failed Pregnancy in Non-IVF Cycles
Status: UNKNOWN
Conditions: Infertility, Female
Interventions: DRUG: Letrozol (Femara, Novartis)|DRUG: Letrozol (Femara, Novartis) combined with Metformin (Cidophage 500 mg, Cid Pharmaceuticals, Egypt)|DRUG: highly purified lyophilized Uroffollitropin (Fostimon, IBSA Institut Biochimique SA, Lugano, Switzerland)|DRUG: highly purified lyophilized Uroffollitropin (Fostimon, IBSA Institut Biochimique SA, Lugano, Switzerland) combined with metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gedatolisib in Combination With Darolutamide in Metastatic Castration-Resistant Prostate Cancer
Status: RECRUITING
Conditions: mCRPC (Metastatic Castration-resistant Prostate Cancer)|Genital Diseases, Male|Urogenital Diseases, Male|Prostatic Disease|Prostatic Neoplasms, Castration-Resistant|Prostate Cancer
Interventions: DRUG: Gedatolisib|DRUG: Darolutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Applied to the Evaluation and Rehabilitation of Locomotion - Study of Tolerance in the Lower Limb Amputee
Status: RECRUITING
Conditions: Unilateral Amputation of the Lower Limb
Interventions: OTHER: Analysis of walking on flat ground|OTHER: Hospital Anxiety Disorder Questionnaire|OTHER: Analysis of walking on slopes|OTHER: Group interview with a sociologist
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Imatinib Mesylate or Dasatinib in Treating Patients With Previously Untreated Chronic Phase Chronic Myelogenous Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Myeloid Leukemia, BCR-ABL1 Positive
Interventions: DRUG: Dasatinib|DRUG: Imatinib Mesylate|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TEOSYAL RHA® 1 for Neck Lines, Perioral Lines and Smiling Lines
Status: UNKNOWN
Conditions: Skin Aging|Fine Lines of the Face and Neck
Interventions: DEVICE: TEOSYAL RHA® 1|DEVICE: TEOSYAL RHA® 1 and TEOSYAL® PureSense Redensity 1 (needle)|DEVICE: TEOSYAL RHA® 1 and TEOSYAL® PureSense Redensity 1 (cannula)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of a Culturally Informed Brief Intervention to Reduce Alcohol Related Health Disparities and Treatment Inequities Among Latinxs
Status: RECRUITING
Conditions: Alcohol Use Disorder
Interventions: BEHAVIORAL: Brief Motivational Interviewing|BEHAVIORAL: Culturally adaptation brief motivational interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Stop(Ruling) of the Antibiotic Treatment During Pneumopathies d' Inhalation
Status: RECRUITING
Conditions: Aspiration Pneumonia
Interventions: PROCEDURE: PCR-based microbiological diagnosis strategy|PROCEDURE: Standard microbiological diagnosis strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Rapid Opiate Detoxification and Naltrexone Induction Using Buprenorphine - 2
Status: COMPLETED
Conditions: Opioid-Related Disorders
Interventions: DRUG: Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dexrabeprazole on Intragastric and Intraesophageal Acidity
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease (GERD)
Interventions: DRUG: Dexrabeprazole 10 mg Enteric-Coated Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study Comparing Pleural Drainage by Videothoracoscopy to Medical Drainage in Infectious Pleural Effusion
Status: COMPLETED
Conditions: Infectious Pleural Effusion
Interventions: DEVICE: Videothoracoscopy drainage|DRUG: Medical drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IPrEP Men's Study: Expanding the Reach of Prevention for Men in Kisumu, Kenya
Status: UNKNOWN
Conditions: HIV
Interventions: DEVICE: UrSure Rapid Urine Tenofovir Test|DEVICE: OraQuick Rapid HIV Self-test kit|DRUG: Tenofovir (300mg)/Emtricitabine(200mg) [Truvada®]|BEHAVIORAL: 2-way text message reminders|BEHAVIORAL: HIV risk-reduction counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prevention of Hepatitis B Virus Reinfection After Liver Transplantation With Entecavir
Status: COMPLETED
Conditions: Liver Transplantation|Hepatitis B|Liver Disease
Interventions: DRUG: Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GA In NEwly Diagnosed Diffuse Large B Cell Lymphoma
Status: TERMINATED
Conditions: Diffuse Large B Cell Lymphoma CD20 Positive
Interventions: DRUG: GA101|DRUG: Rituximab|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Prednisone|DRUG: Bleomycin|DRUG: Vindesin|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Weight Bearing Versus Protected Weight Bearing in Supracondylar Distal Femur Fractures
Status: COMPLETED
Conditions: Closed Supracondylar Fracture of Femur
Interventions: PROCEDURE: Full Weight Bearing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reversal of Right Ventricular Steatosis in Pulmonary Hypertension
Status: WITHDRAWN
Conditions: Pulmonary; Hypertension|Steatosis|Right Ventricular Failure
Interventions: DIETARY_SUPPLEMENT: Omega-3 fatty acids
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Efficacy and Safety of Penpulimab in the Treatment of Metastatic PPGL Patients Who Fail to Other Systemic Treatment
Status: RECRUITING
Conditions: Pheochromocytoma, Metastatic|Pheochromocytoma Malignant|Paraganglioma, Malignant
Interventions: DRUG: Penpulimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Regen Sling to Treatment SUI
Status: UNKNOWN
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: Regen sling|DEVICE: tension-free vaginal tape-obturator(TVT-O)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial for Surgical Treatment of Recurrent Adult Tethered Cord Syndrome
Status: NOT_YET_RECRUITING
Conditions: Recurrent Adult Tethered Cord Syndrome
Interventions: PROCEDURE: Detethering Surgery|PROCEDURE: Spinal Column Shortening Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ramosetron Versus Ondansetron for Radiotherapy Induced Nausea and Vomiting
Status: COMPLETED
Conditions: Radiotherapy Induced Nausea and Vomiting
Interventions: DRUG: ramosetron|DRUG: ondansetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Long-term Safety, Tolerability, and Efficacy of Bimekizumab in the Treatment of Subjects With Active Psoriatic Arthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Psoriatic Arthritis
Interventions: DRUG: Bimekizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Remote Access, Group-based Functional Imagery Training in the Community
Status: UNKNOWN
Conditions: Weight Loss|Health Economics|Quality of Life
Interventions: BEHAVIORAL: Functional Imagery training|BEHAVIORAL: NHS 12 week weight loss programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketogenic Diet in Combination With Standard-of-care Radiation and Temozolomide for Patients With Glioblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: GBM|Glioblastoma
Interventions: OTHER: Ketogenic Diet|RADIATION: Standard-of-care radiation|DRUG: Standard-of-care Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: European Trial of Pirfenidone in BOS, A European Multi-center Study
Status: COMPLETED
Conditions: Disorder Related to Lung Transplantation|CLAD, Bronchiolitis Obliterans
Interventions: DRUG: Pirfenidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Study on the Efficacy of Iron Therapy Using iv Iron Relative to Oral Iron for Increasing LV Systolic Function
Status: RECRUITING
Conditions: Myocardial Infarction|Iron-deficiency
Interventions: DRUG: ferric carboxymaltose|DRUG: ferrous sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of New Combination Inhaler (FlutiForm HFA MDI 100/10 µg) Versus Fluticasone & Formoterol Administered Alone in Patients With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone propionate/Formoterol Fumarate 100/10|DRUG: Fluticasone propionate 100|DRUG: Formoterol fumarate 10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Recombinant Human Glutamic Acid Decarboxylase on the Progression of Type 1 Diabetes in New Onset Subjects
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: GAD-Alum|DRUG: GAD-Alum and Aluminum hydroxide|DRUG: Aluminum hydroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Fish Oil in Alleviating Health Hazards Associated With Ozone Exposure
Status: COMPLETED
Conditions: Cardiovascular System|Respiratory System|Oxidative Stress|Inflammation
Interventions: COMBINATION_PRODUCT: fish oil and acute ozone exposure|COMBINATION_PRODUCT: fish oil and sham exposure|COMBINATION_PRODUCT: soy oil and acute ozone exposure|COMBINATION_PRODUCT: soy oil and sham exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Study to Compare MDCO-2010 vs Placebo and Tranexamic Acid in Patients Undergoing Cardiac Surgery
Status: TERMINATED
Conditions: Bleeding
Interventions: DRUG: MDCO 1|DRUG: MDCO 2|DRUG: MDCO 3|DRUG: MDCO 4|DRUG: Tranexamic Acid|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Impacts of Sugammadex With Neostigmine on Patency of Laryngeal Opening (Glottic Aperture Angle)
Status: UNKNOWN
Conditions: Supraglottic Airway Device Insertion
Interventions: DRUG: Sugammadex|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Short Term Effect of Liraglutide Versus Vildagliptine on Insulin Secretion and Insulin Sensitivity in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: sub cutaneous liraglutide|DRUG: Oral Vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ACL Reconstruction With Simple and Double Bundle Technique Using Two Different Implants for Graft Fixation
Status: UNKNOWN
Conditions: Knee Injuries|ACL Tear|ACL Injury|Sports Injury
Interventions: OTHER: Surgical technique combined with a specific choice of the material for the ligament reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of 4 Weeks of Treatment With Orally Inhaled BI1744/Tiotropium Bromide in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: BI 1744 CL plus tiotropium bromide|DEVICE: Respimat® Inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fed Study of Alprazolam Extended-release Tablets 3 mg to Xanax XR® Tablets 3 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Alprazolam Extended-release Tablets 3 mg|DRUG: Xanax XR® Tablets 3 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Testosterone Treatment in a Patient With 17β-hydroxysteroid Dehydrogenase Type 3 Deficiency: an N-of-1 Study
Status: UNKNOWN
Conditions: Disorder of Sex Development, 46,XY
Interventions: DRUG: Testosterone gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Afatinib(BIBW 2992) in Third-line Treatment for Patients With Stage IIIB/IV Adenocarcinoma of the Lung Harbouring Wild-type Epidermal Growth Factor Receptor[EGFR]
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: afatinib (BIBW 2992)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Point of Care Ultrasound in Endotracheal Tube Placement
Status: RECRUITING
Conditions: Endotracheal Tube Wrongly Placed During Anesthetic Procedure
Interventions: DEVICE: Point of care Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of ASKP1240 in Healthy Subjects After Intravenous and Subcutaneous Administration of ASKP1240
Status: COMPLETED
Conditions: Pharmacokinetics of ASKP1240|Pharmacodynamics of ASKP1240|Healthy Volunteers
Interventions: DRUG: ASKP1240
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effects of Intravenous Acetaminophen on Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults
Status: COMPLETED
Conditions: Fever|Critical Illness
Interventions: DRUG: Acetaminophen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Darolutamide in Addition to ADT Versus ADT in Metastatic Hormone-sensitive Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostatic Neoplasms
Interventions: DRUG: Darolutamide (Nubeqa, BAY1841788)|DRUG: Placebo|OTHER: Androgen deprivation therapy (ADT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Neuro-orthosis on Gait Performer in Post Stroke Subjects
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Foot Drop Stimulator - Neuro Orthosis|DEVICE: Treadmill
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of Diabetes in Adults With Cystic Fibrosis (CF)
Status: WITHDRAWN
Conditions: Cystic Fibrosis
Interventions: OTHER: Oral Glucose Tolerance Test (OGTT) assessment arm|OTHER: Mixed meal test evaluation test arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Montelukast in Seasonal Allergic Rhinitis - Fall 1999 Study (0476A-117)
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Comparator: montelukast/loratadine|DRUG: Comparator: montelukast|DRUG: Comparator: loratadine|DRUG: Comparator: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Methods of Establishing Intersegmental Plane in Segmentectomy
Status: NOT_YET_RECRUITING
Conditions: Surgery
Interventions: PROCEDURE: Implementation of closed insufflation technique during segmentectomy|PROCEDURE: Implementation of dilatation and collapse technique during segmentectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: DRUG: dexamethasone|DRUG: floxuridine|DRUG: fluorouracil|DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Substrate abLatIon as Concomitant trEatment for Left Atrial Macroreentrant Tachycardia
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Line Set Strategy|PROCEDURE: Conventional strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficiency of Three Different Methods in Reducing Pain in Children During Intravenous Cannulation
Status: COMPLETED
Conditions: Child, Only
Interventions: OTHER: Squeezing a ball|OTHER: Blowing bubbles|OTHER: Kaleidoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety Study of Beclometasone/Formoterol Single Inhaler in Patients With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Beclomethasone 100 µg plus formoterol 6 µg (CHF1535) pMDI|DRUG: Budesonide 200 µg plus formoterol 6 µg DPI|DRUG: Formoterol 12 µg DPI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Tislelizumab, Pamiparib, and Other Investigational Agents in Participants With Advanced Malignancies
Status: ENROLLING_BY_INVITATION
Conditions: Advanced Malignancies
Interventions: DRUG: Tislelizumab|DRUG: Pamiparib|DRUG: Temozolomide|DRUG: Sitravatinib|DRUG: Ociperlimab|DRUG: BAT1706|DRUG: Fruquintinib|DRUG: BGB-15025|DRUG: Zanidatamab|DRUG: BGB-A445|DRUG: Surzebiclimab|DRUG: Lenvatinib|DRUG: LBL-007
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Home Care Following Autologous Hematopoietic Stem Cell Transplantation
Status: RECRUITING
Conditions: Well-being of Caregivers (Caregiver Strain Index)
Interventions: OTHER: home care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Membrane Sweeping to Prevent Post-term Pregnancy: The MILO Study
Status: UNKNOWN
Conditions: Pregnancy, Prolonged|Induced; Birth|Pregnancy Related
Interventions: PROCEDURE: Amniotic membrane sweep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics, and Efficacy of Bepotastine Besilate Nasal Product After Ragweed Pollen Exposure in an Environmental Chamber
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: bepotastine besilate nasal product - low dose|DRUG: bepotastine besilate nasal product - medium dose|DRUG: bepotastine besilate nasal product - high dose|DRUG: placebo comparator nasal product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Progressive Relaxation Exercise on Fatigue and Comfort Level After Major Orthopedic Surgery
Status: UNKNOWN
Conditions: Orthopedic Surgery
Interventions: OTHER: Progressive relaxation exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Iota-Carrageenan Eye Drops (NCX-4240)
Status: WITHDRAWN
Conditions: Adenoviral Conjunctivitis
Interventions: DRUG: Iota-Carrageenan|DRUG: Carmellose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Postoperative Analgesia on Systemic Inflammatory Response and POCD After Femoral Fractures Surgery
Status: COMPLETED
Conditions: Postoperative Cognitive Dysfunction
Interventions: DRUG: morphine|DRUG: levobupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study: Evaluation of the Ulthera® System for Treatment of Abdominal Tissue
Status: COMPLETED
Conditions: Skin Laxity|Skin Crepiness
Interventions: DEVICE: Ulthera System Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Decohexaenoic Acid Supplementation on Markers of Inflammatory Muscle Damage
Status: COMPLETED
Conditions: Sport
Interventions: DIETARY_SUPPLEMENT: supplement consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Single Dose Clamp Study To Compare Concentration/Time Profile And Metabolic Activity Profile Of 2 New Formulations Of Insulin Glargine With Lantus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: insulin glargine U200 HOE901|DRUG: insulin glargine U500 HOE901|DRUG: insulin glargine U100 HOE901
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase II Study of Ramucirumab With Chemotherapy in Patients With Metastatic Gastroesophageal Junction and Gastric Cancer
Status: TERMINATED
Conditions: Gastric Cancer|Gastroesophageal Junction Cancer
Interventions: DRUG: Ramucirumab|DRUG: Trastuzumab|DRUG: Capecitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Standard Dose Versus High Dose of Radiotherapy in Rectal Preservation With Chemo-radiotherapy in Rectal Cancer Patients
Status: RECRUITING
Conditions: Cancer of Rectum
Interventions: RADIATION: 50.4 Gy to the tumor and elective volume|RADIATION: 62 Gy to the clinical tumor volume and 50.4 Gy to the elective volume|DRUG: Capecitabine 825 mg/m2 twice daily on weekdays
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Effects of Akkermansia Muciniphila on Insulin Resistance Among Obese Subjects.
Status: RECRUITING
Conditions: Obesity Associated Disorder
Interventions: DRUG: Treatment with Akkermansia muciniphila|OTHER: Treatment with placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Focused Ultrasound Pallidotomy for Dyskinetic Cerebral Palsy in Pediatric and Young Adult Subjects
Status: RECRUITING
Conditions: Cerebral Palsy, Dyskinetic|Secondary Dystonia
Interventions: DEVICE: Focused Ultrasound Pallidotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 'Digitalization in Psychoeducation' The Effect of Tele-Psychoeducation on Problem-Solving Skills and Stress
Status: COMPLETED
Conditions: Stress|Problems Psychosocial
Interventions: BEHAVIORAL: digitalized group psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Donor-Derived CD5 CAR T Cells in Subjects With Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia
Status: RECRUITING
Conditions: T-Cell Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: CD5 CART
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The FLAVO Trial: Dietary Flavonoids and Cardiovascular Disease Risk Reduction in Postmenopausal Women With Type 2 Diabetes
Status: COMPLETED
Conditions: Cardiovascular Disease|Diabetes
Interventions: DIETARY_SUPPLEMENT: Flavonoid enrichment (cocoa / soy compounds)|DIETARY_SUPPLEMENT: Flavonoid enrichment (cocoa / soy compounds)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Voriconazole in Preventing Fungal Infections in Children With Neutropenia After Chemotherapy
Status: COMPLETED
Conditions: Kidney Cancer|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Neuroblastoma|Neutropenia|Sarcoma
Interventions: DRUG: voriconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of Defocus Distributed Multi-point Lens in Myopia Control
Status: UNKNOWN
Conditions: Myopia
Interventions: DEVICE: Defocus Distributed Multi-point lens|DEVICE: Single vision lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Precision Mental Health in Diabetes - Subtypes of Mental Health, Trajectories, and Patterns With Glycaemic Control
Status: RECRUITING
Conditions: Diabetes Mellitus|Depressive Disorder|Depressive Symptoms|Anxiety Disorders|Anxiety and Fear|Eating Disorders|Eating Disorder Symptom|Eating Behavior|Hyperglycemia|Emotional Distress
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Assessing Rocatinlimab in Combination With Topical Corticosteroid and/or Topical Calcineurin Inhibitors in Adult Participants With Moderate-to-severe Atopic Dermatitis (AD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: Rocatinlimab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Medically Used Tailored Traditional Food to Optimize Nutrition in Heart Failure
Status: NOT_YET_RECRUITING
Conditions: Heart Failure
Interventions: OTHER: Medically Tailored Meal Program with Traditional Navajo Foods|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab and Tremelimumab for Pediatric Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Pediatric Cancer|Solid Tumor Pediatric|Hematological Malignancies
Interventions: DRUG: Durvalumab / Tremelimumab Combination Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Luteolin for Two Weeks on Memory in Healthy Subjects
Status: COMPLETED
Conditions: Memory
Interventions: DIETARY_SUPPLEMENT: Luteolin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Examine the Effects of Meditation on Daily Psychological Stress Responses in Woman With a History of Child Adversity
Status: COMPLETED
Conditions: Stress|Psychological Stress|Child Maltreatment|Depressive Symptoms|Signs and Symptoms|Psychological Distress|Psychological
Interventions: BEHAVIORAL: Mindfulness-based intervention, up to 5 minutes 0-3 times/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study To See If GSK256073A Can Block Niacin-Induced Flushing In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Subjects|Dyslipidaemias
Interventions: DRUG: GSK256073A tablets + IR niacin tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Financial Incentives Telephone Education and Skills Trial in African Americans With Diabetes (FITEST)
Status: COMPLETED
Conditions: Diabetes Mellitus|Type 2 Diabetes Mellitus|Adult-Onset Diabetes Mellitus|Non-Insulin-Dependent Diabetes Mellitus|Noninsulin Dependent Diabetes Mellitus, Type II
Interventions: BEHAVIORAL: High Frequency Financial Incentive|BEHAVIORAL: Moderate Frequency Financial Incentive|BEHAVIORAL: Low Frequency Financial Incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Determine the Relative Bioavailability of Different Formulations of AZD9291 and the Effect of Food.
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: AZD9291|DRUG: AZD9291|DRUG: AZD9291|DRUG: AZD9291|DRUG: AZD9291
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Safety of PRV-300 in Adult Subjects With Moderately to Severely Active Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: BIOLOGICAL: PRV-300|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sensory Optimization of the Hospital Environment
Status: RECRUITING
Conditions: Preterm|Parent-Child Relations|Parents|Development, Infant|Sensory Integration Dysfunction
Interventions: BEHAVIORAL: SENSE multisensory program|BEHAVIORAL: Monitored standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Abnormal Structure and Bone Density in Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes|Type 2 Diabetes
Interventions: RADIATION: Radiography|OTHER: Urine and Blood sampling|OTHER: Echography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Histologic Concordance Between Biopsies and the Endoscopic Resection Specimen, in the Treatment of Barrett's Esophagus in Dysplasia, on the Recurrence of Dysplasia
Status: COMPLETED
Conditions: Barretts Esophagus With Dysplasia
Interventions: DIAGNOSTIC_TEST: Pathological revision
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Analgesic Effect of Transcranial Direct Current Stimulation (tDCS) for Sedated Patients in Intensive Care Unit.
Status: NOT_YET_RECRUITING
Conditions: Transcranial Direct Current Stimulation (tDCS)
Interventions: DEVICE: SOOMA™ tDCS™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Increasing Exercise and Decreasing Sedentary Behavior Among Patients in a Cardiac Rehabilitation Clinic
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Heart Failure|Other Cardiac Conditions Among Cardiac Rehabilitation Participants
Interventions: OTHER: B-MOBILE-CARDIAC smartphone application|BEHAVIORAL: Cardiac rehabilitation as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Effectiveness and Safety Study of AQUAVAN® Injection (Fospropofol Disodium) for Sedation During Colonoscopy
Status: COMPLETED
Conditions: Conscious Sedation
Interventions: DRUG: AQUAVAN® (fospropofol disodium) Injection|DRUG: Midazolam HCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Improving Gait Performance in Individuals With Spinal Cord Injuries: an Intervention Using Robotic Exoskeletons
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Robotic exoskeleton training|OTHER: Conventional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endobronchial Intubation of Double-lumen Tube: Conventional Method vs Fiberoptic Bronchoscope Guide Method
Status: COMPLETED
Conditions: Intubation, Intratracheal|Postoperative Complications|Sore Throat|Hoarseness|Soft Tissue Injuries|Thoracic Surgery
Interventions: PROCEDURE: Bronchoscope guided advancement|PROCEDURE: Conventional advancement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Laughter Yoga on Premenstrual Symptoms and Quality of Life in Midwifery Students
Status: NOT_YET_RECRUITING
Conditions: Premenstrual Syndrome|Quality of Life
Interventions: OTHER: Laughter yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: S-FLEX Netherlands Registry: Prospective Evaluation of the Supraflex Family Sirolimus-eluting Coronary Stent System
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: Supraflex Family Sirolimus-eluting Coronary Stent System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sequential MonotherApy of TicagrElor and Clopidogrel After Coronary Intervention
Status: RECRUITING
Conditions: Acute Coronary Syndrome|Percutaneous Coronary Intervention
Interventions: DRUG: Standard-DAPT of Ticagrelor plus aspirin|DRUG: Sequential monotherapy of Ticagrelor and clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Availability & Effect of Post-OP Ketorolac on Ovarian, Fallopian Tube or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Peritoneal Cavity Cancer
Interventions: DRUG: Ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Test the Safety and How Well Patients With Severe Hemophilia A Respond to Treatment With BAY 2599023 (DTX 201), a Drug Therapy That Delivers a Healthy Version of the Defective Factor VIII Gene Into the Nucleus of Liver Cells Using an Altered, Non-infectious Virus (AAV) as a "Shuttle".
Status: ACTIVE_NOT_RECRUITING
Conditions: Hemophilia A
Interventions: DRUG: BAY2599023 (DTX201)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Peginterferon Alfa-2a (Pegasys) and Ribavirin (Copegus) Combination Therapy in Participants With Chronic Hepatitis C (CHC) and Various Degrees of Renal Impairment
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Peginterferon alfa-2a|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of DA-9801 to Treat Diabetic Neuropathic Pain
Status: COMPLETED
Conditions: Diabetic Neuropathies
Interventions: DRUG: DA-9801 300mg|DRUG: DA-9801 600mg|DRUG: DA-9801 900mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pyronaridine Artesunate (3:1) in Children and Adults With Acute Plasmodium Vivax Malaria
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Pyronaridine artesunate|DRUG: Chloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma
Status: RECRUITING
Conditions: Pancreas Cancer
Interventions: PROCEDURE: Irreversible Electroporation (IRE)|DRUG: Gemcitabine|DRUG: FOLFIRINOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of START (Startle Rehabilitation Therapy) in the Treatment Stroke-induced Aphasia/Apraxia
Status: UNKNOWN
Conditions: Stroke|Aphasia|Apraxia of Speech
Interventions: BEHAVIORAL: Startle Adjuvant Rehabilitation Therapy (START)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Venetoclax in Combination With Non-myeloablative Conditioning Allogeneic Haematopoietic Stem Cell Transplantation
Status: RECRUITING
Conditions: Leukemia, Myeloid, Acute|Leukemia, Lymphoblastic, Acute, L1|Leukemia, Lymphoblastic, Acute, L2|Myelodysplastic Syndromes|Non-hodgkin Lymphoma|Plasma Cell Myeloma
Interventions: DRUG: Venetoclax|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial of Clofarabine Added to Standard Busulfan and Fludarabine for Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation
Status: TERMINATED
Conditions: Myeloid Malignancy|Bone Marrow Failure Syndrome|Transfusion-dependent Red Blood Cell (RBC) Defect|Congenital Immunodeficiency|Metabolic Disease|Severe Immune Dysregulation
Interventions: DRUG: Alemtuzumab|DRUG: Busulfan|DRUG: Fludarabine|DRUG: Clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Combining Modified ride-on Cars With Bimanual Training on Enhancing Mobility, Socialization, Motor Function and Participation in Toddlers With Disabilities
Status: COMPLETED
Conditions: Children With Mobility Disabilities
Interventions: BEHAVIORAL: Ride-On Cars with Bimanual Training Program (ROCBT)|BEHAVIORAL: Early Mobility Training Program|BEHAVIORAL: Regular Therapy Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Conventional Versus Digital 3D Printed Complete Removable Dentures
Status: COMPLETED
Conditions: Denture, Complete
Interventions: DEVICE: Polymethyl Methacrylate-Based Complete Removable Dentures.|DEVICE: Photopolymerized Methacrylate- Based Complete Removable Dentures.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of PAC-14028 Cream in Rosacea Patients
Status: COMPLETED
Conditions: Erythematotelangiectatic Rosacea|Papulopustular Rosacea
Interventions: DRUG: PAC-14028 cream 1%|OTHER: Vehicle|DRUG: Rozex gel 0.75%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The SIBERIA Trial (Acculink™ Versus CGuard™)
Status: COMPLETED
Conditions: Patients With Aterosclerotic Carotid Stenosis|Symptomatic Patients (Stenosis > 50%)|Asymptomatic Patients (Stenosis ≥80%)
Interventions: DEVICE: Stent Acculink ™|DEVICE: CGuardTM™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Additional DJ (Duodenojejunostomy)-Pexy on Reduction in Delayed Gastric Emptying Following Pylorus-preserving Pancreaticoduodenectomy: A Prospective, Randomized Controlled Trial
Status: UNKNOWN
Conditions: Delayed Gastric Emptying
Interventions: PROCEDURE: PPPD (pylorus-preserving pancreaticoduodenectomy)|PROCEDURE: PPPD (pylorus-preserving pancreaticoduodenectomy) with DJ-pexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Research Study to Test Safety, Tolerability, and Immunogenicity of a Recombinant Hepatitis B Vaccine Manufactured With an Upgrade to the Production Process (V232-054)
Status: COMPLETED
Conditions: Hepatitis B Infection
Interventions: BIOLOGICAL: V232 Modified Process Hepatitis B Vaccine: Lot A|BIOLOGICAL: V232 Modified Process Hepatitis B Vaccine: Lot B|BIOLOGICAL: V232 Modified Process Hepatitis B Vaccine: Lot C|BIOLOGICAL: V232 Current Process Hepatitis B Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: XG005 for Pain Control in Subjects Undergoing Bunionectomy
Status: RECRUITING
Conditions: Acute Pain
Interventions: DRUG: XG005 tablet|DRUG: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ombitasvir/Paritaprevir/Ritonavir With or Without Dasabuvir in Adults With Genotype 1a or Genotype 4 Chronic Hepatitis C Virus (HCV) Infection, With Severe Kidney Impairment or End Stage Kidney Disease
Status: COMPLETED
Conditions: Hepatitis C Virus (HCV)
Interventions: DRUG: ombitasvir/paritaprevir/ritonavir and dasabuvir|DRUG: ombitasvir/paritaprevir/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Techniques of Uniportal VATS Lobectomies for Clinical Stage I Non-Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Video Assisted Thoracic Surgery (VATS)|Non-Small Cell Lung Cancer (NSCLC)
Interventions: PROCEDURE: uniportal lobectomy with complete lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction Study Evaluating Effects of ASP015K on Rosuvastatin
Status: COMPLETED
Conditions: Healthy Subjects|Pharmacokinetics of ASP015K
Interventions: DRUG: ASP015K|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: