pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Vitamin D Replacement: The Effect on Statin-Related Myalgias
Status: TERMINATED
Conditions: HMG-CoA Reductase Inhibitors-related Myalgias
Interventions: DRUG: cholecalciferol/placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Saline Injection - Assisted Anesthesia in Eyelid Surgery
Status: UNKNOWN
Conditions: Blepharoptosis
Interventions: PROCEDURE: Injection of Saline + Lidocaine/Adrenaline|PROCEDURE: Lidocaine/Adrenaline only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Frozen Section Pathology to Diagnose the IASLC Grades for Lung Adenocarcinoma (ECTOP-1014)
Status: COMPLETED
Conditions: Lung Adenocarcinoma|Surgical Procedure, Unspecified|Pathology
Interventions: PROCEDURE: Surgical resection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy Study of TG-873870 (Nemonoxacin) in Diabetic Foot Infections
Status: COMPLETED
Conditions: Diabetic Foot Infections
Interventions: DRUG: TG-873870 (Nemonoxacin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Motion-Activated Refusal-Skills Training Video Game for Prevention of Substance Use Disorder Relapse
Status: COMPLETED
Conditions: Relapse|Opioid Use|Marijuana Usage
Interventions: BEHAVIORAL: RecoveryWarrior 2.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Donor-Derived Humoral Immunity, Hematopoietic Stem Cell Transplantation, TAR
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Acute Myelogenous Leukemia|Chronic Myelogenous Leukemia|Myelodysplastic Syndrome|Hodgkin Lymphoma|Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: Tetanus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Telephone Consultation as a Substitute for Routine Out-patient Face-to-face Consultation for Children With Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Crohn's Disease|Ulcerative Colitis
Interventions: OTHER: telephone consultations|OTHER: face-to-face consultations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Isolated Hepatic Perfusion With Melphalan Followed by Combination Chemotherapy in Treating Patients With Unresectable Liver Metastases From Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: DRUG: FOLFOX regimen|DRUG: fluorouracil|DRUG: isolated perfusion|DRUG: leucovorin calcium|DRUG: melphalan|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventive Effect of Celecoxib on Sorafenib-related Hand Foot Syndrome, a Single Center, Randomized Controlled Clinical Trail
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Celecoxib|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TDCS to Improve Post-Stroke Cognitive Impairment
Status: RECRUITING
Conditions: Stroke|Stroke Sequelae|Cognitive Impairment
Interventions: DEVICE: Anodal transcranial Direct Current Stimulation (A-tDCS)|DEVICE: Sham Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Crenezumab in Participants With Mild to Moderate Alzheimer Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Crenezumab dose level 1|DRUG: Crenezumab dose level 2|DRUG: Crenezumb dose level 3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BrUOG 379 Phase Ib/II Trial ONC201 + Nivolumab in MSS mCRC
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Dose level 1 ONC201 625mg|DRUG: Dose level 2 ONC201 500mg|DRUG: Dose level 3 ONC201 375mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Biological Markers, Targets, and Intervention for Mood Disorders
Status: TERMINATED
Conditions: Major Depressive Disorder|Depression|Stress
Interventions: BEHAVIORAL: Mindfulness Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immune Checkpoint Inhibitors Intrathecal Injection in Patients With Leptomeningeal Metastases in NSCLC
Status: NOT_YET_RECRUITING
Conditions: NSCLC Associated With Leptomeningeal Metastases
Interventions: DRUG: Tislelizumab, pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Campylobacter Jejuni Challenge Model Development: Dose Ranging Study
Status: UNKNOWN
Conditions: Campylobacter Infections
Interventions: BIOLOGICAL: Campylobacter jejuni strains CG8421 and BH-01-0142
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Apixaban in Patients With Left Ventricular Thrombus
Status: COMPLETED
Conditions: Left Ventricular Thrombus
Interventions: DRUG: Apixaban|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylatic Effect Preoperative Antibiotics With Mechanical Bowel Preparation in SSIs: A Propensity Analysis
Status: COMPLETED
Conditions: Surgical Site Infection|Colorectal Cancer
Interventions: DRUG: Oral antibiotics ( Streptomycin ,metronidazole )
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of WiiFit to Enhance Walking in Older Adult Amputees
Status: COMPLETED
Conditions: Lower Limb Amputation|Older Adults
Interventions: DEVICE: Nintendo Wii|DEVICE: Wii Big Brain Academy Degree program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Echinaforce COVID-19 Shedding Study
Status: TERMINATED
Conditions: COVID-19 Respiratory Infection|SARS-CoV2 Infection
Interventions: DRUG: Echinaforce Forte tablets|DRUG: Echinaforce Chewable tablets|DRUG: Echinaforce tincture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: KIVEXA Vs TRUVADA, Both Administered With Efavirenz, In ART-Naive Subjects
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus I|HIV Infection
Interventions: DRUG: Abacavir/lamivudine and efavirenz|DRUG: Tenofovir/Emtricitabine and efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Inappropriate Benzodiazepine Use Among Older Adults
Status: COMPLETED
Conditions: Long Term Use of Benzodiazepine
Interventions: BEHAVIORAL: Educational Material|BEHAVIORAL: Supplemental Collaborative Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia
Status: UNKNOWN
Conditions: Keratoconus|Ectasia|Corneal Ectasia
Interventions: DEVICE: UV-X Light|DRUG: Riboflavin|DEVICE: UV-X Light|DRUG: Riboflavin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gefitinib in Treating Patients With Esophageal Cancer That is Progressing After Chemotherapy
Status: COMPLETED
Conditions: Adenocarcinoma of the Gastroesophageal Junction|Esophageal Cancer
Interventions: PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neurobiological and Immunological Mechanisms of Dyspnea in ALS (BIOPNEA)
Status: NOT_YET_RECRUITING
Conditions: Shortness of Breath|Dyspnea|Amyotrophic Lateral Sclerosis
Interventions: OTHER: biological test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Alternative Dosing Regimens in the Pharmacotherapy of Insomnia
Status: TERMINATED
Conditions: Insomnia
Interventions: DRUG: Amitriptyline|DRUG: Zolpidem|DRUG: Amitriptyline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Plasmid Elenagen in Combination With Gemcitabine in Patients With Platinum-resistant Ovarian Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer|Platinum-resistant Ovarian Cancer
Interventions: DRUG: Gemcitabine|BIOLOGICAL: ELENAGEN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Autologous CIK Cells in Patients With Hepatocellular Carcinoma After TACE, PEIT or RFA
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: CIK Cell
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bipolar Androgen Therapy to Restore Sensitivity to Androgen Deprivation Therapy for Patients With Metastatic Castration Resistant Prostate Cancer
Status: RECRUITING
Conditions: Castration-Resistant Prostate Carcinoma|Metastatic Prostate Carcinoma|Stage IVB Prostate Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|DRUG: Leuprolide Acetate|PROCEDURE: Magnetic Resonance Imaging|OTHER: Survey Administration|DRUG: Testosterone Cypionate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telephone-Based Genetic Counseling or Standard Genetic Counseling in Women at Risk of Carrying the BRCA1 or BRCA2 Mutation
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Telephone Genetic Counseling|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Open Label Placebo in Children With FGIDs
Status: COMPLETED
Conditions: Functional Abdominal Pain|Functional Dyspepsia|Irritable Bowel Syndrome|Functional Gastrointestinal Disorders
Interventions: OTHER: Placebo Suspension|DRUG: Hyoscyamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Neuroscience-based Technique on Cancer Patients Announced of a Palliative Disease Progression and Partners
Status: TERMINATED
Conditions: Colorectal Cancer|Bladder Cancer|Prostate Cancer|Kidney Cancer|Advanced Sarcoma
Interventions: OTHER: Memory structuring intervention + Vagal breathing|OTHER: support and attention (usual care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Feasibility Study and Predictive Value of the Uterine Cervix Polarimetric Imaging for the Management of the Threat of Premature Delivery.
Status: WITHDRAWN
Conditions: Premature Delivery
Interventions: DEVICE: Uterine Cervix Polarimetric Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Consequence of Injectable Platelets Rich Fibrin Versus Microosteopeforation on Root Resorption During Orthodontic Intrusion of Incisor Teeth
Status: ENROLLING_BY_INVITATION
Conditions: Compare the Effect of Injectable Platelets Rich Fibrin and Micro-osteoperforations on Root Resorption During Orthodontic Intrusion of Incisors
Interventions: COMBINATION_PRODUCT: injectable platelet rich fibrin and microosteoperforation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dextro-Amphetamine Versus Caffeine in Treatment-resistant OCD
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: dextro-amphetamine|DRUG: Sham Comparison
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Amlodipine and Lisinopril on Retinal Autoregulation in Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes|Diabetic Retinopathy|Eye Diseases|Diabetes Complications
Interventions: DRUG: Amlodipine|DRUG: Lisinopril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Optimisation of Mechanical Insufflation:Exsufflation
Status: RECRUITING
Conditions: Neuromuscular Diseases
Interventions: DEVICE: Insufflation|DEVICE: Exsufflation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Vilazodone in Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Placebo|DRUG: Vilazodone|DRUG: Vilazodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CAPRI 2 GOIM Study: Investigate the Efficacy and Safety of a Bio-marker Driven Cetuximab-based Treatment Regimen
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colorectal Adenocarcinoma
Interventions: DRUG: Cetuximab|DRUG: FOLFIRI|DRUG: FOLFOX regimen|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A BRIDGING STUDY OF PF-06439535 (CN) PLUS PACLITAXEL-CARBOPLATIN VERSUS BEVACIZUMAB PLUS PACLITAXEL-CARBOPLATIN IN NSCLC
Status: TERMINATED
Conditions: Advanced Non-squamous NSCLC
Interventions: DRUG: PF-06439535 (CN)|DRUG: Bevacizumab-EU|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-marketing Phase 4 Safety & Tolerability Study of Breztri aerosphereTM in Indian Patients With Chronic Obstructive Pulmonary Disease
Status: NOT_YET_RECRUITING
Conditions: Moderate to Severe COPD
Interventions: DRUG: Breztri Aerosphere
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Irinotecan and Leucovorin/5-fluorouracil Plus Bevacizumab in Metastatic Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: liposomal irinotecan|DRUG: 5-FU|DRUG: LV|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Omeprazole and Low Dose Aspirin to Identify Colorectal Biomarkers of Preventive Efficacy
Status: RECRUITING
Conditions: Colorectal Neoplasia
Interventions: DRUG: Omeprazole|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of the Fixed-dose Combination of Olmesartan + Indapamide When Compared to the Isolated Drugs in the Treatment of Hypertension.
Status: UNKNOWN
Conditions: Hypertension|Hypertension,Essential
Interventions: DRUG: fixed-dose of olmesartan 20mg/40 mg + indapamide 1,5 mg|DRUG: Isolated drugs Olmesartan (20 mg or 40 mg) and Indapamide (1,5 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of ABT-450 With Ritonavir (ABT-450/r) Dosed in Combination With ABT-072 and Ribavirin (RBV)
Status: COMPLETED
Conditions: Hepatitis C|HCV|Chronic Hepatitis C Infection|Hepatitis C Genotype 1
Interventions: DRUG: ABT-450|DRUG: ABT-072|DRUG: Ribavirin|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assess the Efficacy and Safety of Repeat Intravitreal Injections of Foselutoclax (UBX1325) in Patients With DME (ASPIRE)
Status: RECRUITING
Conditions: Diabetic Macular Edema|Retinal Disease|Macular Edema|Diabetes Mellitus|Diabetic Retinopathy|Retinal Degeneration|Retinal Diseases|Eye Diseases|Edema
Interventions: DRUG: Aflibercept|DRUG: foselutoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition
Status: RECRUITING
Conditions: Down Syndrome|Down Syndrome, Partial Trisomy 21|Alzheimer Disease
Interventions: DRUG: [18F]-FEOBV Radiotracer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Radiation Therapy With Protons or Photons in Treating Patients With Liver Cancer
Status: RECRUITING
Conditions: Unrectable or Locally Recurrent Hepatocellular Carcinoma
Interventions: RADIATION: Proton Therapy (Radiation Therapy)|RADIATION: Photon Therapy (Radiation Therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computerized Cognitive Training for Schizophrenia in Brazil
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Computerized cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Speed of Injection and Pain During Routine Infant Vaccinations
Status: UNKNOWN
Conditions: Routine Infant Immunizations|Pain Management
Interventions: OTHER: Fast injection speed by immunizer|OTHER: Slow injection speed by immunizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept (POC) Study of the Soliton Rapid Acoustic (RAP) for the Treatment of Cellulite
Status: COMPLETED
Conditions: Cellulite
Interventions: DEVICE: Soliton Rapid Acoustic Pulse (RAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Stryphnodendron Adstringens Intimate Soap
Status: NOT_YET_RECRUITING
Conditions: Vaginal Flora Imbalance
Interventions: DRUG: Stryphnodendron Adstringens 3% - once daily post bath
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy Trial of Danazol in Patients With Fanconi Anemia or Dyskeratosis Congenita
Status: TERMINATED
Conditions: Fanconi Anemia|Dyskeratosis Congenita
Interventions: DRUG: danazol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ARISE - Aggressive Reduction of Inflammation Stops Events
Status: UNKNOWN
Conditions: Atherosclerosis|Coronary Artery Disease|Myocardial Infarction|Unstable Angina
Interventions: DRUG: AGI-1067
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Alendronate Versus Denosumab in Kidney Transplant Patients
Status: COMPLETED
Conditions: Osteoporosis, Osteopenia|Renal Transplant Recipient
Interventions: DRUG: Denosumab 60 mg/ml [Prolia]|DRUG: Alendronate 70Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the NMDA Antagonist Ketamine as a Treatment for Tinnitus
Status: COMPLETED
Conditions: Tinnitus
Interventions: DRUG: Ketamine Hydrochloride in saline|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Wireless, Implantable Tibial Nerve Stimulator System (eCoin™) for the Treatment of Refractory Lower Urinary Tract Symptoms in Patients With MS
Status: WITHDRAWN
Conditions: Multiple Sclerosis
Interventions: DEVICE: eCoin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women
Status: UNKNOWN
Conditions: Infertility|Polycystic Ovarian Syndrome
Interventions: PROCEDURE: Endometrial Currettage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Linear Growth Failure in Infants and Young Children With Lipid-based Nutrient Supplements (iLiNS-DOSE)
Status: COMPLETED
Conditions: Malnutrition
Interventions: DIETARY_SUPPLEMENT: Lipid-based nutrient supplement, 10gM|DIETARY_SUPPLEMENT: Lipid-based nutrient supplement, 20gM|DIETARY_SUPPLEMENT: Lipid-based Nutrient Supplement, 20gNoM|DIETARY_SUPPLEMENT: Lipid-based nutrient supplement, 40gM|DIETARY_SUPPLEMENT: Lipid-based Nutrient Supplement, 40gNoM|DIETARY_SUPPLEMENT: Maize-soy flour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Hypertonic Saline Solution on Acute Decompensated Heart Failure
Status: RECRUITING
Conditions: Acute Decompensated Heart Failure
Interventions: DRUG: Hypertonic Saline Solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Nivolumab in Combination With Ipilimumab or Standard of Care Chemotherapy Compared to the Standard of Care Chemotherapy Alone in Treatment of Participants With Untreated Inoperable or Metastatic Urothelial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Urothelial Cancer
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: Ipilimumab|DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-based Cognitive-behavioral Treatment for Insomnia in COPD Patients Undergoing Pulmonary Rehabilitation
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|Insomnia
Interventions: BEHAVIORAL: Internet-based behavioral treatment for insomnia|BEHAVIORAL: Online insomnia patient education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of Fostamatinib Upon Cutaneous Inflammation in the Setting of Hidradenitis Suppurativa
Status: COMPLETED
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: Fostamatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Valproic Acid in Subjects With Intact Cognition - Proof of Concept Study
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Valproic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacokinetics, Tolerability and Safety of NEX-18a
Status: COMPLETED
Conditions: Myelodysplastic Syndromes (MDS)|Chronic Myelomonocytic Leukemia (CMML)|Acute Myeloid Leukemia (AML)
Interventions: DRUG: NEX-18a injection|DRUG: Azacitidine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhanced Recovery Pathway for Endoscopy
Status: WITHDRAWN
Conditions: Enhanced Recovery Pathway|Endoscopy
Interventions: DRUG: Ondansetron 4 MG|DRUG: Lactated Ringers, Intravenous|OTHER: Early Mobilization|OTHER: Early PO Intake
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Polyethylene Glycol With Ascorbic Acid and Oral Sulfate Solution for Bowel Preparation
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HAPREP®|DRUG: SUCLEAR®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of StrataXRT in the Prevention of Radiation Dermatitis in Breast Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Radiation Dermatitis
Interventions: DEVICE: StrataXRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Anti-inflammatory Effect of Serum of Osteoarthritis Patients After Administration of the Oléogrape®SEED, an Extract of Grape and Olive
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Extract of grape and olive|DRUG: Lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Fermented Codonopsis Lanceolata on Improvement in Cognitive-Bio-Markers of Cognitive Functions
Status: COMPLETED
Conditions: Subjective Memory Complaints
Interventions: DIETARY_SUPPLEMENT: Fermented Codonopsis lanceolata 525mg|DIETARY_SUPPLEMENT: Fermented Codonopsis lanceolata 1050mg|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inter-organizational Health Planning for Older Adults: Public Dental Care and Municipal Care
Status: NOT_YET_RECRUITING
Conditions: Oral Health|Oral Health Related Quality of Life|Participation|Participation, Patient|Health Planning
Interventions: BEHAVIORAL: Inter-professional team test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Study of VTD in Waldenstrom's Macroglobulinemia
Status: UNKNOWN
Conditions: Waldenstrom Macroglobulinemia|Lymphoplasmacytic Lymphoma
Interventions: DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ramucirumab (LY3009806) in Children With Refractory Solid Tumors
Status: COMPLETED
Conditions: Pediatric Solid Tumor|Refractory Tumor|Recurrent Tumor|CNS Malignancies
Interventions: DRUG: Ramucirumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Single-site Surgery Versus Conventional Entry in Ovarian Cystectomy
Status: UNKNOWN
Conditions: Ovarian Cyst Benign
Interventions: PROCEDURE: Laparoendoscpoic single site surgery LESS|PROCEDURE: Conventional multiport laparoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Etoposide and Cisplatin or Carboplatin as First-Line Chemotherapy With or Without Pravastatin in Treating Patients With Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: cisplatin|DRUG: etoposide phosphate|DRUG: pravastatin sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drug Eluting Balloon for Prevention of Hemodialysis Access Restenosis
Status: COMPLETED
Conditions: Arteriovenous Fistulae|Arteriovenous Graft
Interventions: DEVICE: Paclitaxel Eluting Balloon Angioplasty|DEVICE: Percutaneous Transluminal Angioplasty (PTA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Chorioamnionitis on Platelet Activation and Placental Vessel Among Preterm Infants by Wnt-Flt1 Signal Pathway
Status: COMPLETED
Conditions: Chorioamnionitis|Placenta Diseases|Thrombocytopenia|Preterm Infant
Interventions: OTHER: chorioamnionitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: DNP-Modified Autologous Tumor Cell Vaccine for Resectable Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer - Completely Resectable
Interventions: BIOLOGICAL: L-Vax: Autologous, DNP-Modified NSCLC Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intermittent Theta Burst Stimulation (iTBS) for the Treatment of Negative Symptoms in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: PROCEDURE: active iTBS|PROCEDURE: sham iTBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety Aliviador Compared to Gelol in Patients With Contusions, Sprains, Trauma and Muscle Injury.
Status: UNKNOWN
Conditions: Contusions|Sprains|Trauma|Muscle Injury|Myalgia|Myofascial Pain|Tendinitis
Interventions: DRUG: Aliviador|DRUG: Gelol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Application of Early Physical Therapy Regimens in Patients With Veno-venos Extracorporeal Membrane Oxygenation
Status: UNKNOWN
Conditions: Extracorporeal Membrane Oxygenation Complication
Interventions: BEHAVIORAL: early physiotherapy programs|BEHAVIORAL: routine treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Investigate the Safety and Pharmacokinetics of Lebrikizumab in Healthy Chinese Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DRUG: Lebrikizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy Study of the QuickFlex Micro Model 1258T Left Heart Pacing Lead
Status: COMPLETED
Conditions: Heart Failure
Interventions: DEVICE: QuickFlex Micro Model 1258T Left Heart Lead
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RSA RCT: ATTUNE™ TKA Versus PFC Sigma TKA
Status: COMPLETED
Conditions: Osteoarthritis Arthritis|Joint Diseases|Musculoskeletal Diseases|Rheumatic Diseases
Interventions: DEVICE: ATTUNE™ Knee Prosthesis by DePuy|DEVICE: PFC Sigma Knee Prosthesis by DePuy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cluster Randomized Trial of Knowledge Brokering to Integrate Mood and Smoking Cessation in Ontario Primary Care
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Remote Knowledge Broker (rKB)|BEHAVIORAL: Emails
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multiple Ascending Dose Study of ETC-1002 in Subjects With Mild Dyslipidemia
Status: COMPLETED
Conditions: Mild Dyslipidemia
Interventions: DRUG: ETC-1002 or placebo|DRUG: ETC-1002 or placebo|DRUG: ETC-1002 or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise Training in Patients With Glaucoma
Status: RECRUITING
Conditions: Glaucoma, Open-Angle|Exercise Training|Microvascular Health
Interventions: OTHER: Exercise Training|OTHER: Lifestyle Counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PD-1 Antibody Plus GEMOX as Postoperative Adjuvant Therapy in Perihilar Cholangiocarcinoma
Status: RECRUITING
Conditions: Perihilar Cholangiocarcinoma
Interventions: DRUG: PD-1antibody plus GEMOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Randomized Controlled Trial Evaluating the Role of Negative Pressure Wound Therapy (NPWT) for Incisional Surgical Site Infections in Patients Undergoing Hepatopancreatobiliary Surgery
Status: COMPLETED
Conditions: Hepatobiliary Disease|Hepatobiliary Disorders|Surgical Site Infection
Interventions: OTHER: Negative Pressure Wound Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fractional co2 Laser Followed by Either Vitamin c or Tranexamic Acid in Treatment of Melasma.
Status: NOT_YET_RECRUITING
Conditions: Melasma
Interventions: DEVICE: Fractional co2 laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Combined Effect of Mesenchymal Stem Cell, HA-CaSO4,BMP-2, and Implant in Inducing The Healing of Critical-Sized Bone Defect
Status: UNKNOWN
Conditions: Union
Interventions: DRUG: Mesenchymal stem cell, HA-CaSO4, ¬BMP-2, and Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Galantamine for Improving Dysfunction in People With Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Galantamine-ER|DRUG: Galantamine placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Immune Response to RotaTeq™ Vaccine in the Elderly (V260-027)
Status: TERMINATED
Conditions: Rotavirus
Interventions: BIOLOGICAL: Comparator: RotaTeq|BIOLOGICAL: Comparator: Placebo|BIOLOGICAL: Comparator: RotaTeq + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Abnormal Expression Proteins, Mitochondrial DNA and miRNA of Irritable Bowel Syndrome
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome|Digestive System Diseases|Gastrointestinal Diseases|Intestinal Diseases|Colonic Diseases|Colonic Diseases, Functional
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lumbar Erector Spinae Plane Block for Back Surgery
Status: UNKNOWN
Conditions: Pain, Postoperative|Anaesthesia|Surgery|Nerve Block|Anesthesia, Local|Back Pain|Spinal Fusion
Interventions: PROCEDURE: Erector spinae plane block|DRUG: Levobupivacaine 0,25%|PROCEDURE: spine fusion|DRUG: NaCL 0,9%|DRUG: Sufentanil|DRUG: propofol|DRUG: Rocuronium Bromide|DRUG: sevoflurane|DRUG: paracetamol|DRUG: Ketorolac|DRUG: morphine pca|DRUG: Dexamethasone|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Advanced Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DIAGNOSTIC_TEST: Tumor Imaging|PROCEDURE: Tumor Tissue Collection|PROCEDURE: Blood Sample Collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of SHR6390 in Combination With Letrozole or Anastrozole or Fulvestrant in Patients With HR Positive and HER2 Negative Advanced Breast Cancer
Status: COMPLETED
Conditions: Advanced Breast Cancer
Interventions: DRUG: SHR6390|DRUG: Letrozole or anastrozole or Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Exelon Transdermal Patch in Amnestic Mild Cognitive Impairment Patients
Status: TERMINATED
Conditions: Mild Cognitive Disorder|Mild Cognitive Impairment
Interventions: DRUG: Exelon [rivastigmine] transdermal patch|DRUG: Placebo transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Exparel Transversus Abdominis Plane Block vs Intrathecal Analgesia In Colorectal Surgery
Status: COMPLETED
Conditions: Conditions Requiring Colorectal Surgery
Interventions: DRUG: EXPAREL|DRUG: Intrathecal hydromorphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paricalcitol and Endothelial Function in Chronic Kidney Disease Patients (the PENNY Study)
Status: COMPLETED
Conditions: Chronic Kidney Disease.
Interventions: DRUG: Paracalcitol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Docetaxel and Gemcitabine in Metastatic Esophageal Squamous Cell Cancer
Status: COMPLETED
Conditions: Metastatic Carcinoma|Recurrent Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Gemcitabine/Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label Study of Neuraminidase Inhibitor Treatment in STEMI Patients
Status: UNKNOWN
Conditions: ST Elevation Myocardial Infarction|STEMI
Interventions: DRUG: Oseltamivir phosphate capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Darbepoetin Alfa for Ischemic Surgical Complications (DISC) Dose Finding Trial
Status: COMPLETED
Conditions: Spinal Ischemia|Stroke|Neuroprotection
Interventions: DRUG: Darbepoetin alfa|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Lucentis and Ocular Photodynamic Therapy With Visudyne, With Evaluation-based Retreatment
Status: COMPLETED
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: Ranibizumab|DRUG: Ranibizumab plus Photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of AMG 355 Alone and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: AMG 355|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Electro-physiological Findings and Symptoms Severity in Superior Canal Dehiscence
Status: NOT_YET_RECRUITING
Conditions: Superior Semicircular Canal Dehiscence
Interventions: DIAGNOSTIC_TEST: Wideband tympanometry|DIAGNOSTIC_TEST: Electrocochleography|DIAGNOSTIC_TEST: Vestibular Evoked Myogenic potentials
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Molecular Investigation of GENetic Factors in Cardiovascular and Immune-related Traits and Diseases Using a BIOresource of Healthy Volunteers (GENBIO)
Status: RECRUITING
Conditions: Cardiovascular Diseases
Interventions: OTHER: Questionnaire|OTHER: Anthropometric measurements: height, weight, and body fat|OTHER: Blood pressure and heart rate|PROCEDURE: Venepuncture (GMPR)|PROCEDURE: Venepuncture (SWAP70)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Improving Our Understanding of Respiratory Muscle Training to Facilitate Weaning From Mechanical Ventilation in the ICU
Status: RECRUITING
Conditions: Weaning Failure
Interventions: OTHER: Procedure: Usual Care (UC)|OTHER: Procedure: UC + HI-IMT|OTHER: Procedure: UC + LI-IMT (sham IMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Controlling Hypertension Through Education and Coaching in Kidney Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Kidney Diseases|Chronic Disease|Chronic Kidney Disease, Stage 3 (Moderate)|Chronic Kidney Disease, Stage 4 (Severe)|Chronic Kidney Disease Stage 5
Interventions: BEHAVIORAL: Control-EDI|BEHAVIORAL: Intervention-EDI and health coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of an Effectiveness and Safety of the Electroacupuncture in the Management of Intractable Neuropathic Pain
Status: COMPLETED
Conditions: Neuralgia|Neuralgia; Postherpetic|Diabetic Neuropathy, Painful|Failed Back Surgery Syndrome
Interventions: PROCEDURE: Electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Blinded Randomized Study Comparing Laparoscopic Sleeve Gastrectomy and Laparoscopic Roux-en-y Gastric Bypass and Their Effect on Gastro-Esophageal Reflux Disease Using 24 Horus pH Monitoring
Status: SUSPENDED
Conditions: GERD
Interventions: OTHER: 24 pH monitoring|OTHER: Esophageal Manometry:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan Dose Response Clinical Trial
Status: COMPLETED
Conditions: Central Neuropathic Pain|Allodynia|Spinal Cord Injury
Interventions: DRUG: Dextromethorphan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The SOX Trial: Compression Stockings to Prevent the Post-Thrombotic Syndrome
Status: COMPLETED
Conditions: Deep Venous Thrombosis
Interventions: DEVICE: Knee-length, graduated elastic compression stocking|DEVICE: Knee-length, placebo stocking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of 3 Probiotic Strains on Bile Acids, Satiety, and Inflammation
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Probiotic: Bacillus subtilis|DIETARY_SUPPLEMENT: Lactobacillus plantarum|DIETARY_SUPPLEMENT: Bifidobacterium animalis|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Effect of AZD4041 on Respiratory Drive in Recreational Opioid Users.
Status: COMPLETED
Conditions: Opioid Use Disorder
Interventions: DRUG: AZD4041 and morphine|OTHER: Placebo and morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Use Flexible Bronchoscopes in Interventional Pulmonary Procedures
Status: COMPLETED
Conditions: Atelectasis|Hemoptysis|Stridor
Interventions: DEVICE: Single Use Bronchoscope|DEVICE: Standard Bronchoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The PATHway Study: Primary Care Based Depression Prevention in Adolescents
Status: RECRUITING
Conditions: Depression|Mental Disorder in Adolescence
Interventions: BEHAVIORAL: Competent Adulthood Transition with Cognitive-Behavioral, Humanistic and Interpersonal Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ASYMPTOMATIC CARRIER OF LEISHMANIA INFANTUM, MEDISERRANEAN VISCERAL LEISHMANIOSIS AGENT: STUDY OF IMMUNE RESPONSE -
Status: COMPLETED
Conditions: Leishmaniasis, Cutaneous
Interventions: PROCEDURE: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Improving Gait Adaptability in Hereditary Spastic Paraplegia
Status: COMPLETED
Conditions: Hereditary Spastic Paraplegia|Strumpell Disease
Interventions: BEHAVIORAL: C-mill intervention|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE