pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Moxetumomab Pasudotox-tdfk (Lumoxiti(TM)) and Either Rituximab (Rituxan(R)) or Ruxience for Relapsed Hairy Cell Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Hairy Cell Leukemia
Interventions: DRUG: Moxetumomab Pasudotox-tdfk|BIOLOGICAL: Rituximab|BIOLOGICAL: Ruxience|DRUG: Dexamethasone|DRUG: Acetaminophen|DRUG: Diphenhydramine|DRUG: Famotidine|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Acute Kidney Injury by Erythropoietin in Thoracic Aorta Surgery With Hypothermic Cardiac Arrest
Status: COMPLETED
Conditions: Dissection of Thoracic Aorta
Interventions: DRUG: recombinant human erythropoietin|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: sEphB4-HSA in Treating Patients With Metastatic Castration-Resistant Prostate Cancer
Status: UNKNOWN
Conditions: Castration Levels of Testosterone|Castration-Resistant Prostate Carcinoma|Castration-Resistant Prostate Carcinoma Refractory to Second-Generation Androgen Receptor Axis-Targeted Agents|Metastatic Prostate Adenocarcinoma|Progressive Disease|Prostate Carcinoma Metastatic in the Bone|Prostate Carcinoma Metastatic in the Soft Tissue|PSA Progression|Stage IVB Prostate Cancer AJCC v8|Testosterone Less Than 50 ng/dL
Interventions: BIOLOGICAL: Recombinant EphB4-HSA Fusion Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Carcinoma of Unknown Primary|Metastatic Adrenal Gland Pheochromocytoma|Metastatic Kidney Medullary Carcinoma|Metastatic Malignant Germ Cell Tumor|Metastatic Malignant Solid Neoplasm|Metastatic Paraganglioma|Metastatic Penile Carcinoma|Metastatic Skin Squamous Cell Carcinoma|Small Cell Carcinoma|Stage III Adrenal Cortex Carcinoma AJCC v7|Stage IV Adrenal Cortex Carcinoma AJCC v7|Stage IV Penile Cancer AJCC v7|Stage IV Renal Cell Cancer AJCC v7|Unresectable Adrenal Gland Pheochromocytoma|Unresectable Paraganglioma|Unresectable Skin Squamous Cell Carcinoma|Unresectable Solid Neoplasm|Vascular Neoplasm
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HIVEC in Patients With Non-Muscle-Invasive Bladder Cancer
Status: NOT_YET_RECRUITING
Conditions: Non-Muscle-Invasive Bladder Cancer
Interventions: PROCEDURE: TURBT|PROCEDURE: HIVEC|PROCEDURE: Intravesical Chemotherapy|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Oral Care With Colostrum for Preventing Late-onset Sepsis in Preterm Infants
Status: COMPLETED
Conditions: Prematurity
Interventions: OTHER: Mother's colostrum|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Multicenter Clinical Study of the SING-IMT in Patients With Late-stage AMD
Status: RECRUITING
Conditions: Age-Related Macular Degeneration|Geographic Atrophy
Interventions: DEVICE: smaller incision, new generation implantable miniature telescope (SING-IMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase I Study of Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Escalating Dose I.P. Platinum for Gastrointestinal Peritoneal Carcinomatosis
Status: COMPLETED
Conditions: Peritoneal Neoplasms|Stomach Neoplasms
Interventions: PROCEDURE: CHPP with cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Ipilimumab With or Without Nivolumab in Relapsed/Refractory cHL
Status: ACTIVE_NOT_RECRUITING
Conditions: Hodgkin Lymphoma|Relapsed Hodgkin's Disease, Adult|Refractory Hodgkin Lymphoma
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeting a Genetic Mutation in Glycine Metabolism With D-cycloserine
Status: COMPLETED
Conditions: Schizophrenia|Bipolar Disorder
Interventions: DRUG: D-cycloserine|DRUG: DCS or placebo|DRUG: D-cycloserine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Precision Dosing of Busulfan in Children Undergoing HSCT
Status: RECRUITING
Conditions: Hematopoietic Stem Cell Transplantation|Allogeneic Hematopoietic Stem Cell Transplantation|Autologous Hematopoietic Stem Cell Transplantation
Interventions: GENETIC: GSTA1 genotyping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vitamin C & Exercise Induced Bronchoconstriction (EIB)
Status: WITHDRAWN
Conditions: Exercise-induced Bronchospasm
Interventions: DIETARY_SUPPLEMENT: Vitamin C|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Optimization of Outpatient Surgery at the CHUM Using the LeoMed Telecare Platform
Status: COMPLETED
Conditions: Surgery--Complications|Patient Satisfaction|Quality of Life
Interventions: OTHER: Complete LeoMed application|OTHER: Basic LeoMed application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bupivacaine Pharmacokinetics in Ultrasound-guided Axillary Brachial Plexus Block.
Status: COMPLETED
Conditions: Pharmacokinetics|Anesthetics, Local
Interventions: DRUG: Bupivacaine 0,25%|DRUG: Bupivacaine 0,5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Research Study on the Immunosuppressive Effects of a Cell Therapy Product on PBMC Isolated From Blood of Patients With Inflammatory Rheumatic Diseases
Status: TERMINATED
Conditions: Rheumatoid Arthritis|Psoriatic Arthritis|Spondylarthritis
Interventions: OTHER: Blood sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Obstructive Sleep Apnea Destabilizes Myocardial Repolarization Homogeneity
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Heart Rhythm Disorder|Obesity, Abdominal
Interventions: DIAGNOSTIC_TEST: Polygraphy monitoring|DIAGNOSTIC_TEST: laboratory tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Imatinib Mesylate in Treating Patients With Locally Advanced Gastrointestinal Stromal Tumor
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumor
Interventions: DRUG: imatinib mesylate|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Versus Percutaneous Biliary Drainage for Resectable Pancreatic Head Cancer
Status: COMPLETED
Conditions: Pancreatic Head Cancer|Obstructive Jaundice
Interventions: PROCEDURE: pancreaticoduodenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of ChimeriVax™-JE Vaccine to Prevent Japanese Encephalitis.
Status: COMPLETED
Conditions: Encephalitis|Japanese Encephalitis
Interventions: BIOLOGICAL: ChimeriVax-JE, Japanese Encephalitis vaccine|BIOLOGICAL: 0.9% Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Feasibility Study Implant of the WiSE® CRT System With an Intracardiac Pacemaker to Achieve Totally Leadless CRT
Status: NOT_YET_RECRUITING
Conditions: Heart Failure
Interventions: DEVICE: WiSE CRT System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK/PD Study of Subcutaneous Cenderitide Infusion in CHF Patients
Status: COMPLETED
Conditions: Heart Failure|ADHF|Chronic Heart Failure|CHF
Interventions: DRUG: Cenderitide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Reducing Distress And Improving Glycemic Control In Adults With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: BEHAVIORAL: 'KnowIt'|BEHAVIORAL: 'OnTrack'
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycaemic & Cardiovascular Treatment Outcomes of Voglibose Vs Glibenclamide Added to Metformin in T2DM Patients
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus Type 2 Without Complication
Interventions: DRUG: Voglibose + Metformin|DRUG: Glibenclamide + Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donafenib Plus Sintilimab in Combination With TACE in Patients With Unresectable Hepatocellular Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Unresectable Hepatocellular Carcinoma
Interventions: COMBINATION_PRODUCT: Donafenib plus Sintilimab in combination with transarterial chemoembolisation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COMPARISON OF DEXMEDETOMIDINE AND REMIFENTANIL FOR POSTOPERATIVE PAIN IN TRANSPHENOIDAL Pituitary SURGERY
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Dexmedetomidine|DRUG: Remifentanyl
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Modified Angled Tube vs. Conventional Angled Tube in Double-lumen Endotracheal Tube Intubation
Status: COMPLETED
Conditions: Intubation, Intratracheal|Thoracic Surgical Procedures
Interventions: DEVICE: Mallinckrodt endotracheal tube with a modified angle|DEVICE: Mallinckrodt endobronchial tube with a conventional angle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Sublingual Versus Intranasal Administration of Dexmedetomidine for Sedation of Children Undergoing Dental Treatment
Status: COMPLETED
Conditions: Anti-anxiety Agents|Moderate Sedation
Interventions: DRUG: Intranasal Dexmedetomidine|DRUG: Sublingual Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "A Long-Term Safety Study of JZP-110 in the Treatment of Excessive Sleepiness in Subjects With Narcolepsy or OSA"
Status: COMPLETED
Conditions: Narcolepsy|Obstructive Sleep Apnea
Interventions: DRUG: JZP-110
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reproducibility of External Anal Sphincter Elastic Properties Assessment Using Elastography During Pregnancy
Status: UNKNOWN
Conditions: Obstetric Anal Sphincter Injury
Interventions: DIAGNOSTIC_TEST: Shear wave elastography assessment of the external anal sphincter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of the Drivers of Late Diagnosis of Alcohol Related Diseases, Alone or in Combination With Metabolic Dysfunconal Associated Fatty Liver Disease, Implementation and Evaluation of Itnerventions to Reduce Its Burden.
Status: RECRUITING
Conditions: Alcohol-related Liver Disease|Alcohol Use Disorder|Metabolic and Alcohol Related/Associated Liver Disease|Metabolic Disfunction Associated Steatotic Liver Disease
Interventions: BEHAVIORAL: brief intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors
Status: TERMINATED
Conditions: Adult Anaplastic Astrocytoma|Adult Anaplastic Ependymoma|Adult Anaplastic Oligodendroglioma|Adult Brain Stem Glioma|Adult Central Nervous System Germ Cell Tumor|Adult Choroid Plexus Tumor|Adult Craniopharyngioma|Adult Diffuse Astrocytoma|Adult Ependymoblastoma|Adult Ependymoma|Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Adult Grade I Meningioma|Adult Grade II Meningioma|Adult Grade III Meningioma|Adult Medulloblastoma|Adult Meningeal Hemangiopericytoma|Adult Mixed Glioma|Adult Myxopapillary Ependymoma|Adult Oligodendroglioma|Adult Pilocytic Astrocytoma|Adult Pineoblastoma|Adult Pineocytoma|Adult Subependymoma|Adult Supratentorial Primitive Neuroectodermal Tumor (PNET)|Meningeal Melanocytoma
Interventions: DRUG: EF5|PROCEDURE: conventional surgery|PROCEDURE: positron emission tomography|RADIATION: fluorine F 18 EF5|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: "Ecological Program Changes Pelvic Kinematics in Soccer Players: Pilot Study on Hamstring Injury Implications"
Status: COMPLETED
Conditions: Anterior Pelvic Tilt|Sprint Kinematics
Interventions: OTHER: Multicomponent program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Aerobic Exercise Training on Cardiorespiratory Function in Patients With Traumatic Brain Injury
Status: COMPLETED
Conditions: Exercise|Fatigue|Physical Fitness|Traumatic Brain Injury
Interventions: OTHER: Aerobic Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical and MRI Cardiac Biomarkers on Peripheral Arterial Disease in Patients With Long Term DM
Status: UNKNOWN
Conditions: Peripheral Arterial Disease
Interventions: PROCEDURE: Invasive treatment|OTHER: Conservative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy
Status: RECRUITING
Conditions: Head and Neck Neoplasms|Mucositis Oral|Radiotherapy; Complications
Interventions: DRUG: Copaiba
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Double-Blind, Parallel, Randomised Study to Investigate the Effect of Oral Probiotics in Infants With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis|Atopic Eczema|Infantile Eczema
Interventions: DRUG: probiotics: Lactobacillus GG, lactobacillus Rhamnosus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Study of Abemaciclib, Durvalumab, and an Aromatase Inhibitor Early Stage Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer Female|Locally Advanced Breast Cancer|Hormone Receptor Positive Malignant Neoplasm of Breast
Interventions: DRUG: Abemaciclib, durvalumab and aromatase inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Telerehabilitation Practice in Long COVID-19 Patients
Status: RECRUITING
Conditions: Long COVID-19|Long COVID|Post COVID-19 Condition|Post-COVID-19 Syndrome|Post-COVID Syndrome
Interventions: BEHAVIORAL: Telerehabilitation|BEHAVIORAL: Standard rehabilitation care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Use of Amiodarone in Atrial Fibrillation Associated With Severe Sepsis or Septic Shock
Status: TERMINATED
Conditions: New Onset Atrial Fibrillation|Severe Sepsis|Septic Shock
Interventions: DRUG: Amiodarone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gabapentin for Insomnia Symptoms and Nighttime Vasomotor Symptoms (VMS) in Peri- and Postmenopausal Women
Status: COMPLETED
Conditions: Menopause|Hot Flashes|Vasomotor Disturbance
Interventions: DRUG: Gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of TAH Combination in Comparison With Telmisartan/Amlodipine Combination for Essential Hypertension Patients
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Telmisartan/Amlodipine+Hydrochlorothiazide|DRUG: Telmisartan/Amlodipine|DRUG: Placebo for Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Pharmacokinetics of JNJ-38518168 in Japanese and Caucasian Male Participants and the Effect of JNJ-38518168 on the Blood Levels of Midazolam
Status: COMPLETED
Conditions: Healthy Male Volunteer
Interventions: DRUG: JNJ-38518168 (30 mg)|DRUG: JNJ-38518168 (10 mg)|DRUG: JNJ-38518168 (3 mg)|DRUG: Placebo|DRUG: Midazolam and JNJ-38518168
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Outcome Study of Conventional Steroids vs. Steroids Combined With Mycopehnolate in Newly Diagnosed Immune Thrombocytopenia Purpura.
Status: RECRUITING
Conditions: Immune Thrombocytopenia Purpura
Interventions: DRUG: Mycophenolate Mofetil (MMF) Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Comparison of Application of Curcumin Gel in Pain Management After Free Gingival Graft Harvesting
Status: RECRUITING
Conditions: Palate; Wound
Interventions: OTHER: curcumin gel 2%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Posterior Tibial Nerve Stimulation (PTNS) Plus Mirabegron to Treat Refractory OAB Symptoms (PTNS-M Study)
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: Mirabegron 50 MG|DEVICE: Posterior Tibial Nerve Stimulation (PTNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imetelstat for Children With Refractory or Recurrent Solid Tumors and Lymphoma
Status: WITHDRAWN
Conditions: Solid Tumors|Lymphoma
Interventions: DRUG: Imetelstat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GLUCOSAFE 2 - A New Tool for Nutritional Management and Insulin-therapy in the Intensive Care Unit (ICU)
Status: RECRUITING
Conditions: Critical Illness|Energy Supply; Deficiency, Severe|Protein Deficiency|Hypoglycemia|Hyperglycemia
Interventions: DEVICE: GLUCOSAFE 2|DEVICE: Local protocol control group with routine care|DEVICE: Historical control group with routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sputum Cytometry Guided Management for the Elimination of Chronic Cough in Patients With ILD
Status: NOT_YET_RECRUITING
Conditions: ILD
Interventions: OTHER: Sputum-guided management|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cannabis and Opioid Use Disorder
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder
Interventions: DRUG: Inhaled vaporized cannabis|DRUG: Intransal opioid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Coronary Artery Disease Assessment Strategies in TAVI Patients
Status: NOT_YET_RECRUITING
Conditions: Transcatheter Aortic Valve Replacement|Coronary Artery Disease|Heart Disease Risk Factors
Interventions: DIAGNOSTIC_TEST: Risk-based CAD management|DIAGNOSTIC_TEST: Invasive coronary angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: (NAVIGATOR) Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumors (GIST)|Other Relapsed or Refractory Solid Tumors
Interventions: DRUG: Avapritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-time Monitoring of Kidney Grafts on Hypothermic Machine Perfusion
Status: UNKNOWN
Conditions: Transplant;Failure,Kidney
Interventions: DIAGNOSTIC_TEST: Monitoring biochemical concentrations during cold machine perfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Effect of Repeat Doses of GW870086X in Mild to Moderate Asthmatics
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: GW870086X|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nudging Providers to Curtail Dangerous Opioid Prescribing: A Trial to Investigate Mechanisms
Status: COMPLETED
Conditions: Opioid Use
Interventions: BEHAVIORAL: PMP Use Mandate Letter|BEHAVIORAL: Prescribing Information Letter|BEHAVIORAL: Prescribing Information + PMP Use Mandate Letter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety, Tolerability, and Efficacy of Etrasimod (APD334) in Participants With Primary Biliary Cholangitis
Status: TERMINATED
Conditions: Primary Biliary Cholangitis
Interventions: DRUG: APD334
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tourniquet Reduces Blood Loss in Postpartum Hemorrhage During Hysterectomy for Placenta Accreta
Status: COMPLETED
Conditions: Placenta Accreta|Post Partum Hemorrhage|Blood Loss Massive
Interventions: PROCEDURE: Tourniquet: Folley catheter in the low segment of the uterus
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Prospective, Multicenter, Randomized, Comparator-controlled, Evaluator-blinded Study to Evaluate the Safety and Effectiveness of VP1 Lido US for Volume Augmentation of the Cheek
Status: COMPLETED
Conditions: Cheek Volume Augmentation
Interventions: DEVICE: VP1 Lido US|DEVICE: Restylane Lyft Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is the Efficacy of Epidural Steroid Injections Related to the Different Volume Injections?
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Triamcinolone|DRUG: Epidural Volume|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Embolization of Large Spontaneous Portosystemic Shunts for the Prevention of Post-TIPS Hepatic Encephalopathy
Status: COMPLETED
Conditions: Liver Cirrhosis
Interventions: PROCEDURE: TIPS|PROCEDURE: SPSS embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Low Dose Rituximab as a First Line Biologic Therapy for the Treatment of DMARD Resistant Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: DMARD Resistant Rheumatoid Arthritis
Interventions: DRUG: Rituximab|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Marrow Versus Adipose Autologous Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis
Status: UNKNOWN
Conditions: Osteo Arthritis Knee
Interventions: BIOLOGICAL: bone marrow mesenchymal stem cells|BIOLOGICAL: Adipose Mesenchymal stem cells|BIOLOGICAL: bone marrow & adipose mesenchymal stem cells injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adenosine Receptor Antagonist Combination Therapy for Metastatic Castrate Resistant Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostatic Neoplasms, Castration-Resistant|Androgen-Resistant Prostatic Neoplasms|Castration Resistant Prostatic Neoplasms|Prostatic Cancer, Castration-Resistant
Interventions: DRUG: Etrumadenant|DRUG: Zimberelimab|DRUG: Quemliclustat|DRUG: Enzalutamide|DRUG: Docetaxel|DRUG: SG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Routine Physical Therapy With and Without Thoracic Mobility Exercises in Chronic Neck Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: Routine Physical Therapy with Thoracic mobility exercise|OTHER: Routıne Physıcal therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Awake Caudal Catheter vs General Anesthesia
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: DRUG: Bupivacaine, Dexmedetomidine, Caffeine, Tylenol|DRUG: Propofol, rocuronium, caffeine, Tylenol, bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Long Term Follow up Administration Study of L059 (Levetiracetam) in Epilepsy Patients With Partial Onset Seizures
Status: COMPLETED
Conditions: Epilepsies|Partial
Interventions: DRUG: Levetiracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Staggered, Chemo-Immunotherapy With Durvalumab, MEDI4736 Pemetrexed & Carboplatin (PC) for Metastatic Non-Squamous NSCLC
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer Metastatic
Interventions: DRUG: Durvalumab|DRUG: Pemetrexed|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block With Bupivacaine for Medical Thoracoscopy
Status: RECRUITING
Conditions: Pleural Disease|Postoperative Pain
Interventions: DRUG: Bupivacaine injection|DRUG: Placebo|OTHER: Monitored Anesthesia Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Molecular Detection for the Improved Diagnosis of Invasive Pulmonary Aspergillosis and Invasive Pulmonary Zygomycosis
Status: COMPLETED
Conditions: Immunocompromised Host|Invasive Pulmonary Fungal Infection|Invasive Pulmonary Aspergillosis|Invasive Pulmonary Zygomycosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety, Reactogenicity, and Immunogenicity Study of mRNA-1045 (Influenza and Respiratory Syncytial Virus [RSV]) or mRNA-1230 (Influenza, RSV, and Severe Acute Respiratory Syndrome Coronavirus 2 [SARS-CoV-2]) Vaccine in Adults 50 to 75 Years Old
Status: COMPLETED
Conditions: SARS-CoV-2|Influenza|RSV
Interventions: BIOLOGICAL: mRNA-1010|BIOLOGICAL: mRNA-1345|BIOLOGICAL: mRNA-1273.214|BIOLOGICAL: mRNA-1045|BIOLOGICAL: mRNA-1230
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of AT-527 in Healthy Subjects Under Fasting Conditions or With a Meal
Status: COMPLETED
Conditions: Healthy Volunteer Study
Interventions: DRUG: AT-527 fasted|OTHER: Placebo Comparator fasted|DRUG: AT-527 fed|OTHER: Placebo Comparator fed|DRUG: AT-527|DRUG: AT-527 single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An International, Multicenter, Randomized, Double-Blind, Parallel Group, Vehicle-Controlled, Phase 2/3 Study With Open-Label Extension Evaluating the Efficacy and Safety of Diacerein 1% Ointment for the Treatment of Generalized Epidermolysis Bullosa Simplex (EBS)
Status: RECRUITING
Conditions: Generalized Epidermolysis Bullosa Simplex
Interventions: DRUG: AC-203|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exemestane in Treating Postmenopausal Women With Resected Stage I, Stage II, or Stage IIIA Breast Cancer Who Have Completed 5 Years of Tamoxifen
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: exemestane|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fractionated Gemtuzumab Ozogamicin Followed by Non-engraftment Donor Leukocyte Infusions for Relapsed/Refractory Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Gemtuzumab Ozogamicin (GO)|OTHER: Donor Leukocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of the Talk Test for Exercise Prescription for Home-Based Cardiac Rehabilitation
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: BEHAVIORAL: Talk test prescription|BEHAVIORAL: CPET prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Neuromodulation of Inflammation and Endothelial Function
Status: RECRUITING
Conditions: Systolic Heart Failure
Interventions: DEVICE: neuromodulation device|DEVICE: SHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Can a Simple Trephination Increase the Heeling Potential for All-inside Meniscal Repair in the Vascular Zone?
Status: UNKNOWN
Conditions: Rupture; Meniscus, Bucket Handle
Interventions: PROCEDURE: trephination|PROCEDURE: Normal meniscal repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transversus Thoracic Muscle Plane Block for Open Heart Surgery
Status: COMPLETED
Conditions: Pain, Acute|Pain, Chest
Interventions: DRUG: Bupivacaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Glucose Measurement With Raman Technology in Patients With Type 1 and Type 2 Diabetes
Status: COMPLETED
Conditions: Diabete Mellitus|Medical Device
Interventions: DEVICE: Prototype 0.3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety of GQ1001 in Adult Patients With HER2-Positive Advanced Solid Tumors
Status: RECRUITING
Conditions: HER2-positive Breast Cancer|HER2-positive Biliary Tract Cancer|HER2-Positive Salivary Gland Carcinomas|HER2-Positive Advanced Solid Tumor
Interventions: DRUG: GQ1001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of GTx-024 in Patients With Estrogen Receptor (ER)+/Androgen Receptor (AR)+ Breast Cancer
Status: COMPLETED
Conditions: ER+ and AR+ Breast Cancer
Interventions: DRUG: GTx-024
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Preparation With Lugol Solution in Patients With Graves-Basedow Disease.
Status: COMPLETED
Conditions: Hyperthyroidism, Autoimmune
Interventions: DRUG: Lugols Strong Iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oxytocin-augmented Cognitive-behavioral Group-based Short-term Intervention for Loneliness
Status: UNKNOWN
Conditions: Loneliness
Interventions: DRUG: Oxytocin nasal spray|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Heating on Exercise Pressor Reflex in Peripheral Artery Disease: Exercise Ability
Status: RECRUITING
Conditions: PAD
Interventions: OTHER: Without Heating|OTHER: Warm Bath|OTHER: Neutral Bath|OTHER: Heating Suit|OTHER: Lower limb warm water immersion|OTHER: Gardner walking protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 1/2 Dose Finding and Safety Study of Ibrutinib in Pediatric Subjects With Chronic Graft Versus Host Disease (cGVHD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Graft Versus Host Disease
Interventions: DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of a Single Dose of ASP3291 in Subjects With Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: ASP3291|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: This Study is Done in Healthy Chinese and Japanese Volunteers; it Looks at How BI 690517 is Taken up in the Body and How Well it is Tolerated
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 690517|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of Surrogate Measures in Irritable Bowel Syndrome (IBS)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Escitalopram treatment|BEHAVIORAL: Quantitative sensory testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Effects of Glucagon Like Peptide 1 (GLP-1) Analogues on Fluid Intake
Status: COMPLETED
Conditions: Thirst|Water-Electrolyte Imbalance
Interventions: DRUG: Dulaglutide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar Fasciitis
Status: COMPLETED
Conditions: Plantar Calcaneal Spur|Fasciitis, Plantar
Interventions: DEVICE: algometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Initial Dual Oral Combination Therapy Versus Standard-of-care Initial Oral Monotherapy Prior to Balloon Pulmonary Angioplasty in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension
Status: RECRUITING
Conditions: Thromboembolic Pulmonary Hypertension|Chronic Disease|Inoperable Disease
Interventions: DRUG: Macitentan 10mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Investigational Immuno-therapy Trial of Pomalidomide and Low-dose Dexamethasone With or Without Elotuzumab to Treat Refractory and Relapsed and Refractory Multiple Myeloma (ELOQUENT-3)
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Elotuzumab|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Interaction Between Low Dose Sulfamethoxazole-Trimethoprim and Zidovudine
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Sulfamethoxazole-Trimethoprim|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-Management Training and Automated Telehealth to Improve SMI Health Outcomes
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Bipolar Disorder|Depression
Interventions: BEHAVIORAL: CBHH+AT|BEHAVIORAL: CBHH+SMT|BEHAVIORAL: CBHH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Mometasone Furoate Nasal Spray in Children With Adenoid Hypertrophy. SNORE Study (P05155)
Status: COMPLETED
Conditions: Adenoids Hypertrophy
Interventions: DRUG: Mometasone Furoate nasal spray|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Change in C-reactive Protein (CRP) in Men and Women With Sleep Apnea After Continuous Positive Airway Pressure (CPAP)
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: PROCEDURE: Continuous Positive Airway Pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Adjunctive Ganaxolone Treatment in Female Children With Protocadherin 19 (PCDH19)-Related Epilepsy (Violet Study)
Status: COMPLETED
Conditions: PCDH19-Related Epilepsy
Interventions: DRUG: Ganaxolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Hypoxia Imaging in Advanced Pancreatic Cancer Patients Being Treated With Gemcitabine and TH-302 or TH-302 Placebo
Status: WITHDRAWN
Conditions: Pancreatic Adenocarcinoma|Advanced Disease|Metastatic Disease
Interventions: DRUG: 18F-Fluoroazomycin arabinoside
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Manipulation of Sacroiliac Joints on the Static Balance of the Body
Status: COMPLETED
Conditions: Asymptomatic Condition|Sacroiliac Disorder
Interventions: OTHER: HVLA Manipulations|OTHER: Sham Manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Image-Based, In-Vivo Assessment of Tumor Hypoxia to Guide Hypoxia-Driven Adaptive Radiation Therapy
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma|Brain Metastases
Interventions: PROCEDURE: Magnetic Resonance Imaging (MRI)|PROCEDURE: Positron Emission Tomography (PET)|DRUG: 18F-fluoromisonidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessment of Verbal Comprehension and Cognitive Processes in Patients Admitted to the Palliative and Supportive Care Unit
Status: SUSPENDED
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Locally Advanced Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm|Recurrent Malignant Solid Neoplasm
Interventions: PROCEDURE: Electroencephalography|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Improving Outcomes Among Medical/Surgical Inpatients With Alcohol Use Disorders
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: BEHAVIORAL: Drinking Options - Motivate, Shared Decisions, Telemonitor (DO-MoST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Confirmatory Study of TAU-284 in Pediatric Patients With Perennial Allergic Rhinitis
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis
Interventions: DRUG: TAU-284|DRUG: TAU-284|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Food-Effect Study of an Oral Nitisinone Formulation to Treat Hereditary Tyrosinemia (HT-1)
Status: COMPLETED
Conditions: Hereditary Tyrosinemia, Type I
Interventions: DRUG: Nitisinone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety Study to Evaluate Induction and Consolidation Treatment in Patients With Mantle Cell Lymphoma (LCM-04-02)
Status: COMPLETED
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Y-90 Ibritumomab tiuxetan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy With Chemotherapy as Neoadjuvant Therapy of Resectable and Borderline Resectable Pancreas Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: DRUG: Capecitabine|RADIATION: Standard Dose Acclerated Fraction Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Setmelanotide Effects on QTc (Corrected QT) Interval in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Setmelanotide|DRUG: Moxifloxacin|DRUG: Oral Placebo|DRUG: SC Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fatigue in Sarcoidosis - Treatment With Methylphenidate
Status: UNKNOWN
Conditions: Sarcoidosis|Fatigue
Interventions: DRUG: Methylphenidate (overencapsulated)|DRUG: Placebo (Over-encapsulated tablet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotics on Gut-Liver Axis of Alcoholic Hepatitis
Status: UNKNOWN
Conditions: Alcoholic Liver Disease
Interventions: DRUG: Probiotics (Lacidofil®)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sunshine 2 Study for Women With Diabetes
Status: COMPLETED
Conditions: Diabetes|Depression|Quality of Life
Interventions: DRUG: Vitamin D3|DRUG: Vitamin D3 comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cystic Fibrosis Diagnosis by Analyzing Nasal Brushing
Status: UNKNOWN
Conditions: Cystic Fibrosis|Atypical Form of Cystic Fibrosis
Interventions: OTHER: Nasal brushing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Phase I Study of Recombinant Human Nerve Growth Factor Injection
Status: UNKNOWN
Conditions: Injury of Optic Nerve
Interventions: DRUG: Recombinant human nerve growth factor injection,experimental|DRUG: Recombinant human nerve growth factor injection,single dose|DRUG: Recombinant human nerve growth factor injection,multiple dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Epidural Analgesia for Pancreatitis (Epipan Study)
Status: COMPLETED
Conditions: Severe Acute Pancreatitis
Interventions: OTHER: ropivacaine and sufentanil|OTHER: acetaminophen, nefopam, tramadol, opidoids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reproducibility Inter-session of the Measurement Elastography of the Passive Stiffness of Medial Beams of Gastrocnemius Muscle of the Hemiplegic Cerebral Child.
Status: COMPLETED
Conditions: Gait|Child Development|Hemiplegic
Interventions: DEVICE: ultrasound scanner
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Single-Agent Carboplatin vs the Combination of Carboplatin and Everolimus for the Treatment of Advanced Triple-Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Carboplatin|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT