pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Problem-Solving Intervention for Family Caregivers in Palliative Oncology
Status: COMPLETED
Conditions: Palliative Care|Caregivers|Medical Oncology
Interventions: BEHAVIORAL: Problem-Solving Intervention|OTHER: Unenhanced Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: QBECO SSI for Clinical and Endoscopic Remission in Moderate to Severe Crohn's Disease
Status: TERMINATED
Conditions: Crohn Disease
Interventions: BIOLOGICAL: QBECO-SSI|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety, Tolerability and Efficacy of KPT-8602 in Participants With Relapsed/Refractory Cancer Indications
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed/Refractory Multiple Myeloma (RRMM)|Metastatic Colorectal Cancer (mCRC)|Metastatic Castration-Resistant Prostate Cancer (mCRPC)|Higher-Risk Myelodysplastic Syndrome (HR-MDS)|Acute Myeloid Leukemia (AML)|Newly Diagnosed Intermediate/High-Risk MDS
Interventions: DRUG: KPT-8602|DRUG: ASTX727|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retrospective Clinical Investigation of the Safety and Performance of 640PM Trifocal IOL Implantation in Patients With Cataract and/or Ametropia (Hyperopia, Myopia) and/or Presbyopia
Status: COMPLETED
Conditions: Cataract|Presbyopia|Hyperopia|Myopia|Pseudophakia
Interventions: DEVICE: Intraocular lens
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Liposomal Irinotecan Plus Bevacizumab in Irinotecan-refractory Metastatic Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: Liposomal irinotecan|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ramelteon in Healthy Subjects
Status: COMPLETED
Conditions: Sleep Disorder
Interventions: DRUG: Ramelteon|DRUG: Ramelteon|DRUG: Ramelteon|DRUG: Ramelteon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study to Assess the Safety, Pharmacokinetics, & Pharmacodynamics of GSK923295 in Subjects w/ Refractory Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: GSK923295
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-management and Home Exercises for the Treatment of Masticatory Muscle Pain. A Clinical Trial
Status: COMPLETED
Conditions: Myalgia of Mastication Muscle
Interventions: BEHAVIORAL: Self-management|OTHER: Home exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of McKenzie and Trochanteric Belt With CT Therapy to Reduce Pain and Dysfunction of SI Joint
Status: RECRUITING
Conditions: Sacroiliac Joint Dysfunction
Interventions: BEHAVIORAL: McKenzie exercise|DIAGNOSTIC_TEST: Trochanteric belt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase II Trial of Decitabine in Patients With Chronic Myelogenous Leukemia Accelerated Phase Who Are Refractory to Imatinib Mesylate (Gleevec)
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia
Interventions: DRUG: decitabine (5-aza-2'deoxycytidine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ⅱ Trial of Pyrotinib Combination With CDK4/6 Inhibitor SHR6390 in Patients Prior Trastuzumab-treated Advanced HER2-Positive Breast Cancer
Status: UNKNOWN
Conditions: Metastatic Breast Cancer|HER2-positive Breast Cancer
Interventions: DRUG: Pyrotinib|DRUG: SHR6390|DRUG: Letrozole|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of SBRT and Immunotherapy in Small Hepatocellular Carcinoma (HSBRT2402)
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: RADIATION: Stereotactic body radiotherapy|DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Osteopathy and Prevention of Gastrointestinal Side Effects in Women Treated for Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: osteopathic technique|PROCEDURE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study the Efficacy of Topical Antibiotherapy in the Prophylaxis of Incisional Surgical Infection in Colorectal Surgery
Status: COMPLETED
Conditions: Surgical Wound Infection|Postoperative Wound Infection|Postoperative Wound Infection Superficial Incisional|Preventive Therapy
Interventions: DRUG: Amoxicillin Clavulanate|DRUG: Physiological Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficacy and Safety of Methylprednisolone Combined With the JAK Inhibitors in the Treatment of Toxic Epidermal Necrolysis
Status: RECRUITING
Conditions: Toxic Epidermal Necrolysis
Interventions: DRUG: Abrocitinib|DRUG: Tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alkontrol-herbal Effects on Alcohol Drinking
Status: COMPLETED
Conditions: Alcohol Drinking|Alcohol Use Disorder|Alcohol Abstinence
Interventions: DIETARY_SUPPLEMENT: kudzu extract, puerarin|DIETARY_SUPPLEMENT: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Hepatitis B Virus (HBV) Before Beginning Anti-HIV Drugs in Patients With Both HBV and HIV
Status: WITHDRAWN
Conditions: HIV Infections|Hepatitis B
Interventions: DRUG: Telbivudine|DRUG: Lamivudine|DRUG: Efavirenz|DRUG: Didanosine|DRUG: Abacavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuum: Digital Health to Manage Heart Failure Outpatients
Status: COMPLETED
Conditions: Heart Failure|Chronic Heart Failure
Interventions: OTHER: Continuum HFC-IN|OTHER: Standard of care for the follow-up|OTHER: Continuum HFC-OUT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Role of Learning in Nocebo Hyperalgesia
Status: COMPLETED
Conditions: Nocebo Effects|Hyperalgesia|Chronic Pain|Pain Syndrome
Interventions: BEHAVIORAL: Conditioning with partial reinforcement|BEHAVIORAL: Conditioning with continuous reinforcement|BEHAVIORAL: Counterconditioning|BEHAVIORAL: Extinction|BEHAVIORAL: Sham Conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Influence of Lidocaine Temperature on Pain During Subcutaneous Administration
Status: COMPLETED
Conditions: Needlestick Injuries
Interventions: PROCEDURE: Low temperature lidocaine injection|PROCEDURE: Room temperature lidocaine injection|PROCEDURE: Body temperature lidocaine injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study of Rociletinib Administered to Patients With Previously Treated Mutant EGFR Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Rociletinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Blood and Tissue Samples in Predicting Response to Second-Line Therapy Using Erlotinib Hydrochloride or Chemotherapy in Patients With Advanced Non-Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: docetaxel|DRUG: erlotinib hydrochloride|DRUG: pemetrexed disodium|GENETIC: fluorescence in situ hybridization|GENETIC: mutation analysis|GENETIC: proteomic profiling|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|OTHER: matrix-assisted laser desorption/ionization time of flight mass spectrometry|PROCEDURE: breath test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Gastric Bypass Hypoglycemia
Status: COMPLETED
Conditions: Hyperinsulinemic Hypoglycemia
Interventions: OTHER: high carbohydrate test meal|OTHER: high carbohydrate test meal after pre-treatment with rapid acting aspart insulin|OTHER: high fructose , low glucose test meal with carbohydrate and caloric content similar to the control meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Analysis of Aldehyde Biomarkers of Exposure and Host Response
Status: TERMINATED
Conditions: Smoking Cessation
Interventions: DRUG: nicotine polacrilex|DRUG: nicotine transdermal system|DRUG: nicotine inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sintilimab Combined With Bevacizumab and Liver Protective Support Therapy in Unresectable Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Sintilimab|DRUG: Bevacizumab|COMBINATION_PRODUCT: Liver Protective Support Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sodium Bicarbonate Supplementation in Chronic Kidney Disease Evaluation of Dose Response, Safety and Beneficial Effects
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Sodium bicarbonate|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Compare Efficacy and Safety of Raltitrexed-based and 5fu-based Neoadjuvant Chemotherapy for Colorectal Liver Metastasis
Status: TERMINATED
Conditions: Colorectal Cancer|Liver Metastasis
Interventions: DRUG: Raltitrexed-based chemotherapy|DRUG: Raltitrexed-based chemotherapy|DRUG: 5-fluorouracil-based chemotherapy|DRUG: 5-fluorouracil-based chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The CANTATA-MP Trial (CANagliflozin Treatment and Trial Analysis - Metformin and Pioglitazone)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo|DRUG: Canagliflozin|DRUG: Sitagliptin|DRUG: Metformin|DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of JTE-051 in Subjects With Moderate to Severe Plaque Psoriasis
Status: TERMINATED
Conditions: Plaque Psoriasis|Skin Diseases
Interventions: DRUG: JTE-051|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Statins in Patients With Type 2 Diabetes Mellitus and Previous History of Acute Coronary Syndrome
Status: COMPLETED
Conditions: Hydroxymethylglutaryl-CoA Reductase Inhibitors|Diabetes Mellitus
Interventions: DRUG: Atorvastatin 40 Mg Oral Tablet|DRUG: Rosuvastatin 20 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemp 15 mg & 50 mg Capsule Absorption
Status: COMPLETED
Conditions: Absorption; Chemicals
Interventions: DIETARY_SUPPLEMENT: 15 mg/g Full Spectrum Hemp Extract|DIETARY_SUPPLEMENT: 50 mg/g Full Spectrum Hemp Extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Efficacy of Vosevi in Treating DAA-experienced Patients
Status: RECRUITING
Conditions: Chronic Hepatitis C|Medication Reaction
Interventions: DRUG: Sofosbuvir / Velpatasvir / Voxilaprevir Oral Tablet [Vosevi]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Biceps Tenodesis Alone Versus Biceps Tenodesis and Labrum Repair in Superior Labrum Anteroposterior (SLAP) Lesion Type IV
Status: NOT_YET_RECRUITING
Conditions: SLAP Lesion
Interventions: PROCEDURE: Biceps tenodesis alone|PROCEDURE: Biceps tenodesis and labrum repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Randomized Controlled Study of Radiotherapy and the Concurrent Three-week and Single-week TP Chemotherapy for Advanced Cervical Squamous Cell Carcinoma and the Correlation Between HPV Classification and Sensitivity.
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: PROCEDURE: The concurrent 3 weeks TP regimen|PROCEDURE: The concurrent weekly TP regimen|RADIATION: External radiation plus intraluminal after-loading irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insomnia and Drug Relapse Risk
Status: COMPLETED
Conditions: Poor Quality Sleep|Opiate Addiction
Interventions: DRUG: Trazodone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Spinal Cord Stimulation in Patients With Chronic Intractable Pain
Status: UNKNOWN
Conditions: Pain|Chronic Pain|Back Pain|Spinal Cord Stimulation|Nervous System Diseases
Interventions: DEVICE: PINS Spinal Cord Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Higher Dose (HD) Nusinersen (BIIB058) in Participants With Spinal Muscular Atrophy Previously Treated With Risdiplam
Status: RECRUITING
Conditions: Spinal Muscular Atrophy
Interventions: DRUG: Nusinersen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing in Livertransplantation Recipients With Tacrolimus Alone Versus Tacrolimus&Sirolimus
Status: COMPLETED
Conditions: Liver Disease
Interventions: DRUG: Tacrolimus and Sirolimus|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CEA Targeting Chimeric Antigen Receptor T Lymphocytes (CAR-T) in the Treatment of CEA Positive Advanced Solid Tumors
Status: RECRUITING
Conditions: Gastric Cancer|Colon Cancer|Rectal Cancer|Esophageal Cancer|Pancreas Cancer|Lung Cancer|Breast Cancer
Interventions: BIOLOGICAL: CEA-targeted CAR-T cells|BIOLOGICAL: CEA-targeted CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Randomized Study of Mesenchymal Stem Cell Therapy in Patients Undergoing Cardiac Surgery (PROMETHEUS)
Status: TERMINATED
Conditions: Stem Cell Transplantation|Ventricular Dysfunction, Left
Interventions: BIOLOGICAL: Lower dose mesenchymal stem cell (MSC) injection|GENETIC: Placebo|BIOLOGICAL: Higher dose MSC injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transplantation of Microbes for Treatment of Metabolic Syndrome & NAFLD
Status: COMPLETED
Conditions: Diabetes Mellitus|Non-alcoholic Fatty Liver Disease
Interventions: BIOLOGICAL: Autologous|BIOLOGICAL: Allogeneic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Synergistic Effects of Aerobic Exercise and Cognitive Training on Cognition in Stroke Patients With Cognitive Decline
Status: UNKNOWN
Conditions: Stroke Patients With Cognitive Decline
Interventions: BEHAVIORAL: Cognitive training|BEHAVIORAL: Aerobic exercise training|BEHAVIORAL: Sequential combination of aerobic exercise and cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BXQ-350 in Newly Diagnosed Metastatic Colorectal Carcinoma
Status: RECRUITING
Conditions: Metastatic Colorectal Carcinoma|Neuropathy
Interventions: DRUG: BXQ-350|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Detection of Residual Disease in Children Receiving Therapy for Acute Myeloid Leukemia or Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: GENETIC: polymerase chain reaction|OTHER: flow cytometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Pharmacokinetics of Kovacaine Nasal Spray in Pediatric Subjects
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Tetracaine HCl 3% and Oxymetazoline HCl 0.05%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of Two Daily Disposable Contact Lenses - Study 1
Status: COMPLETED
Conditions: Refractive Errors
Interventions: DEVICE: Verofilcon A contact lenses|DEVICE: Etafilcon A contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Person- Centred Care Among Nursing Home Patients With Dementia
Status: COMPLETED
Conditions: Dementia|Agitation
Interventions: BEHAVIORAL: Staff training using VIPS|BEHAVIORAL: Staff training using DCM|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intravenous Tranexamic Acid and Intramyometrial Desmopressin Effect on Blood Loss During Laparoscopic Myomectomy.
Status: COMPLETED
Conditions: Leiomyoma, Uterine|Intraoperative Blood Loss
Interventions: DRUG: Tranexamic acid|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 1 Study of Anti-Macrophage Migration Inhibitory Factor (Anti-MIF) Antibody in Solid Tumors
Status: COMPLETED
Conditions: Metastatic Adenocarcinoma of the Colon or Rectum|Malignant Solid Tumors
Interventions: BIOLOGICAL: Anti-Macrophage Migration Inhibitory Factor (Anti-MIF) Antibody|BIOLOGICAL: Anti-Macrophage Migration Inhibitory Factor (Anti-MIF) Antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: This Study Will Compare the Effect of Starch Containing to Non-Starch Containing Intravenous Fluid on Blood Loss During Coronary Artery Bypass Graft Surgery
Status: UNKNOWN
Conditions: Bloodloss
Interventions: OTHER: HES (130/0.4)|OTHER: Ringer's Lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety Intervention for Improving Functioning in Suicidal Attempters
Status: NOT_YET_RECRUITING
Conditions: Suicide, Attempted|Functioning, Psychosocial
Interventions: BEHAVIORAL: Safety Intervention Planning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate MET409 Alone or in Combination With Empagliflozin in Patients With Type 2 Diabetes and NASH
Status: UNKNOWN
Conditions: NASH|NASH - Nonalcoholic Steatohepatitis|Type 2 Diabetes|Diabetes Type 2|Diabetes|Fatty Liver|Fatty Liver, Nonalcoholic|NAFLD
Interventions: DRUG: MET409 Active|DRUG: MET409 Placebo|DRUG: Empagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Maplirpacept (PF-07901801) in Combination With PLD in Patients With Platinum-Resistant Ovarian Cancer
Status: TERMINATED
Conditions: Ovarian Cancer|Ovarian Neoplasms|Ovarian Carcinoma|Fallopian Tube Cancer|Epithelial Ovarian Cancer|Primary Peritoneal Carcinoma
Interventions: DRUG: maplirpacept (PF-07901801)|DRUG: Pegylated Liposomal Doxorubicin (PLD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MK0653A (Ezetimibe (+) Simvastatin) Compared to an Approved Drug (Atorvastatin) for the Treatment of High Cholesterol (0653A-051)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: MK0653A, ezetimibe (+) simvastatin|DRUG: Comparator: atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neurobehavioral Correlates of Caffeine on Anxiety, Avoidance and Interoception in Healthy Individuals and Panic Disorder.
Status: NOT_YET_RECRUITING
Conditions: Panic Disorder|Healthy
Interventions: DIETARY_SUPPLEMENT: Caffeine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Demonstrate the Relative Bioavailability of Hydroxychloroquine Sulfate, 200 mg Tablets
Status: COMPLETED
Conditions: Immunosuppression|Rheumatism
Interventions: DRUG: Hydroxychloroquine Sulfate Tablets, 200 mg (Geneva Pharmaceutical, Inc.)|DRUG: Hydroxychloroquine Sulfate Tablets, 200 mg, Plaquenil (Sanofi Winthrop)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Zoledronic Acid in High Risk Giant Cell Tumour of Bone (GCT)
Status: TERMINATED
Conditions: Giant Cell Tumor of Bone|Osteoclastoma
Interventions: DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Valspodar in Treating Patients With Previously Untreated Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: etoposide|DRUG: valspodar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Dexmedetomidine to Facilitate Extubation in Surgical ICU Patients Who Failed Previous Weaning Attempts
Status: TERMINATED
Conditions: Intubation; Difficult|Respiration Disorders
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Telmisartan/Amlodipine Fixed-dose Combination Compared to Its Mono-components in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Telmisartan/amlodipine fixed-dose combination tablet|DRUG: Telmisartan|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest of Non Invasive Ventilation Versus Oxygen During the Intial Managment of Infant With Bronchiolitis
Status: COMPLETED
Conditions: Bronchiolitis|Respiratory Distress
Interventions: DEVICE: Infantflow [EME, Brighton, England]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode.
Status: COMPLETED
Conditions: Acute Heart Failure
Interventions: DRUG: sacubitril/valsartan (LCZ696)|DRUG: Enalapril|DRUG: sacubitril/valsartan (LCZ696) matching placebo|DRUG: enalapril matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Different Kinds of Acupuncture Treatment for Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: treatment1|OTHER: treatment2|OTHER: treatment3|OTHER: treatment4|OTHER: treatment5|DRUG: Celebrex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Resolving the Burden of Low Back Pain in Military Service Members and Veterans: A Pragmatic Clinical Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Low Back Pain
Interventions: BEHAVIORAL: Clinical Practice Guidelines and Psychologically Informed Physical Therapy training/audit/feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Technology Coaching Intervention for Black Women With Hypertension
Status: COMPLETED
Conditions: Uncontrolled Hypertension
Interventions: BEHAVIORAL: Interactive Technology Enhanced Coaching (ITEC)|BEHAVIORAL: Interactive Technology-No Coaching (IT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabetes Prevention Program in Adults of the Yaqui Tribe of Hermosillo, Sonora at Risk of Diabetes
Status: COMPLETED
Conditions: Prediabetes|Obesity|Overweight
Interventions: BEHAVIORAL: Lifestyle Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Tenofovir Disoproxil Fumarate (DF) in Asian-American Adults With Chronic Hepatitis B Infection
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Tenofovir disoproxil fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 177Lu-DOTATATE for Recurrent Meningioma
Status: NOT_YET_RECRUITING
Conditions: Recurrent Meningioma
Interventions: DRUG: Local standard of Care|DRUG: 177Lu-DOTATATE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Maralixibat in Biliary Atresia Response Post-Kasai
Status: COMPLETED
Conditions: Biliary Atresia
Interventions: DRUG: Maralixibat|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MRI DWI None-Gaussian Model Predicting Early Response to Immunotherapy in Digestive System Malignancies: a Prospective Observational Study
Status: UNKNOWN
Conditions: Immunotherapy|Digestive System Neoplasm
Interventions: RADIATION: MRI test|RADIATION: MRI test|RADIATION: MRI test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized Proof-of-Concept Trial to Evaluate the Safety and Explore the Effectiveness of Resveratrol, a Plant Polyphenol, for COVID-19
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Resveratrol|DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Transcatheter Artificial Aortic Valve and Transcatheter Artificial Heart Values Delivery System
Status: UNKNOWN
Conditions: Severe Aortic Stenosis|Aortic Regurgitation
Interventions: DEVICE: Jenscare TAVI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Naltrexone for Chronic Pain From Arthritis
Status: COMPLETED
Conditions: Osteoarthritis|Arthritis, Rheumatoid|Arthritis, Psoriatic
Interventions: DRUG: Naltrexone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of and Immune Response to a Modified Vaccinia Ankara (MVA) HIV Vaccine in HIV Uninfected Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: MVA-CMDR|BIOLOGICAL: Placebo|BIOLOGICAL: MVA-CMDR|BIOLOGICAL: Placebo|BIOLOGICAL: MVA-CMDR|BIOLOGICAL: MVA-CMDR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Cool Dialysate on the Sleep/Wake Cycle in Patients on Chronic Hemodialysis - "The Sleep Cool Study"
Status: COMPLETED
Conditions: End-stage Renal Disease
Interventions: PROCEDURE: Cool Dialysate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Predictors of Response to Biventricular Pacing in Heart Failure
Status: COMPLETED
Conditions: Heart Failure, Wide QRS Complex
Interventions: DEVICE: echo-guided left ventricular lead placement|OTHER: LV lead placement as per standard of care (without echo guidance)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Gut-Cued Eating on BMI and Efficacy of Open-Label Placebo to Augment Weight Loss
Status: COMPLETED
Conditions: Eating Behavior|Obesity|Body Weight|Hunger
Interventions: BEHAVIORAL: Placebo pill and no placebo pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Individual Counseling and/or Computer-Based Counseling in Helping Healthy Women Adopt a Cancer Prevention Diet
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BEHAVIORAL: dietary counseling via computer|BEHAVIORAL: dietary counseling via nutritionist|BEHAVIORAL: combined computer and nutritionist|OTHER: physical activity counseling via computer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics and Comparative Bioavailability of Nicotine From Two Variants of NP2, NP2-4mg and NP2-6mg, Compared to Nicotine Lozenge 4mg (Loz-4mg) and Nicotine Gum 4mg (Gum-4mg)
Status: COMPLETED
Conditions: Tobacco Use
Interventions: OTHER: NP2-4mg|OTHER: NP2-6 mg|OTHER: Loz-4mg|OTHER: Gum-4mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interaction Between the Vaginal and Seminal Microbiome in Patients With an Altered Vaginal Microbiome Pattern Resistant to Treatment
Status: UNKNOWN
Conditions: Fertility Disorders
Interventions: OTHER: Analysis of the seminal microbiome of the partners of women with altered vaginal microbiome resistant to drug treatment|OTHER: Analysis of the seminal microbiome of the partners of women with altered vaginal microbiome not resistant to drug treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Standard Antibiotic Versus Enhanced Prophylactic Measures on Rate of Urinary Tract Infection After Flexible Ureteroscopy
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: DRUG: IV fluoroquinolone 1 hour preoperatively and oral antibiotics for 24h postoperatively.|OTHER: Urine culture, antibiotic prophylaxis and hydrophilic-coated ureteral access sheaths
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: START - Early Thrombocyte Administration to Patients With Ruptured Abdominal Aortic Aneurism
Status: UNKNOWN
Conditions: Ruptured Abdominal Aortic Aneurism
Interventions: PROCEDURE: Platelet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Assistive Powered Wheelchair: Stage 2 Trial
Status: COMPLETED
Conditions: Multiple Sclerosis|Stroke|Cystic Fibrosis|Motor Neurone Disease|Craniocerebral Trauma|Guillain-Barre Syndrome
Interventions: DEVICE: Powered Wheelchair Obstacle Alerting System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Electrochemotherapy of Posterior Resection Surface for Lowering Disease Recurrence Rate in Pancreatic Cancer (PanECT Study)
Status: TERMINATED
Conditions: Pancreas Cancer
Interventions: PROCEDURE: Electrochemotherapy - electroporation with Cliniporator Vitae® and chemotherapy drug Bleomycin PHC 15 e. (United States Pharmacopeia - USP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Nivolumab and Relatlimab in Advanced Mismatch Repair Deficient Cancers Resistant to Prior PD-(L)1 Inhibitor
Status: RECRUITING
Conditions: Refractory MSI - H Solid Tumors Prior of PD-(L) 1 Therapy|MSI-H Tumors
Interventions: DRUG: Nivolumab|DRUG: Relatlimab|DRUG: Nivolumab|DRUG: Relatlimab|DRUG: Nivolumab|DRUG: Relatlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Soothing and Re-epithelizing Activity of New Cosmetic Formulations in Comparison to Placebo and Untreated Control Area
Status: COMPLETED
Conditions: Sensitive Skin
Interventions: OTHER: P926 - LICHTENA DermAD CREMA VISO|OTHER: P927 - LICHTENA DermAD CREMA CORPO|OTHER: P926 - LICHTENA DermAD CREMA VISO - PLACEBO|OTHER: Untreated control area
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Diagnosis (PDD) in Flexible Cystoscopy
Status: COMPLETED
Conditions: Bladder Cancer|Recurrence|PDD
Interventions: DRUG: hexaminoavolunate|PROCEDURE: WL cystoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy and Pharmacokinetic of BPI-9016M in Patients With c-Met- Dysregulated Advanced NSCLC
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: BPI-9016M
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of rhAngiostatin Administered in Combination With Paclitaxel and Carboplatin to Patients With Non-Small-Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: recombinant human Angiostatin protein|DRUG: paclitaxel|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study to Assess Mechanisms in Peripheral Tissue Innervation for Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: Duloxetine|PROCEDURE: Skin biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembro and Vorinostat for Patients With Stage IV Non-small Cell Lung Cancer (NSCLC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer|Non-small Cell Lung Cancer
Interventions: DRUG: Vorinostat|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study to Evaluate BMS-767778 in Healthy Subjects and Subjects With Type 2 Diabetes Mellitus (T2DM)
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: BMS-767778 or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Increased Salt Sensitivity of Ambulatory Blood Pressure in Women With a History of Severe Preeclampsia
Status: COMPLETED
Conditions: Preeclampsia
Interventions: DIETARY_SUPPLEMENT: high sodium diet|DIETARY_SUPPLEMENT: low-salt diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Research Study on How NNC0487-0111 Works in People With Overweight or Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: NNC0487-0111 A|DRUG: NNC0487-0111 B|OTHER: Placebo B (NNC0487-0111 B)|OTHER: Placebo A (NNC0487-0111 A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Skin Structure Infections With Suspected or Proven Methicillin-Resistant Staphylococcus Aureus (MRSA)
Status: COMPLETED
Conditions: Skin/Soft Tissue Infections|Methicillin Resistant Staphylococcus Aureus (MRSA)
Interventions: DRUG: linezolid|DRUG: vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Access to Low-dose Ritonavir (TMC114/r) and Other Antiretrovirals (ARVs) for Treatment-naive or Early Treatment Experienced in HIV-1 Patients
Status: COMPLETED
Conditions: HIV-1
Interventions: DRUG: TMC114/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strategy of Early Improvement of Tissue Oxygenation Decrease the Mortality of Severe Sepsis and Septic Shock
Status: COMPLETED
Conditions: Shock, Septic
Interventions: PROCEDURE: lactate group:lactate acide clearance directed group; ScvO2 group:ScvO2 directed group;control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of the Lack of CMV-Specific CD8+ T Cell Response in CMV-Seropositive Donors in CMV Reactivation After Hematopoietic Stem Cells Transplant in CMV-Seropositive Recipients
Status: UNKNOWN
Conditions: Cytomegalovirus Infection|HSCT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Exercise in the Functional Capacity, Central Artery and Rigidity Ankle Brachial Index
Status: UNKNOWN
Conditions: Peripheral Arterial Disease
Interventions: OTHER: Device: treadmill|OTHER: Device: treadmill Train_Comb_aerobic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RAPA-501 Therapy for ALS
Status: NOT_YET_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: BIOLOGICAL: RAPA-501 Autologous T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Apnea and Fetal Growth Restriction
Status: TERMINATED
Conditions: Obstructive Sleep Apnea|Fetal Growth Restriction|Pregnancy Related
Interventions: DEVICE: S9 VPAP Adapt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical IL-1-Ra for Treatment of Corneal Neovascularization
Status: TERMINATED
Conditions: Corneal Neovascularization
Interventions: DRUG: Placebo|DRUG: IL-1Ra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of AP-306 in Hyperphosphatemia Patients
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Hyperphosphatemia
Interventions: DRUG: AP-306|DRUG: Sevelamer Carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Multicenter Study for the Assessment of Treatment Patterns, Effectiveness and Safety of Secukinumab in Adult Patients With Moderate to Severe Plaque Psoriasis in a Real-world Setting in China
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: secukinumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Acute Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: filgrastim|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: melphalan|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Injectable Platelet-Rich Fibrin (i-PRF) in Initial Treatment of Chronic Periodontitis
Status: COMPLETED
Conditions: Periodontitis
Interventions: DRUG: SRP + Injectable Platelet-Rich Fibrin|DRUG: SRP + placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and PK in Healthy Volunteers and HCV Genotype 1 Infected Patients
Status: COMPLETED
Conditions: Healthy|Hepatitis C, Chronic
Interventions: DRUG: TG-2349|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Symptom Tracking in Long COVID Patients Using Formula C™ Sublingual Drops
Status: RECRUITING
Conditions: Long COVID|Long Covid19|Post-Acute COVID-19|Post-Acute COVID-19 Syndrome|Long Haul COVID|Long-Haul COVID-19
Interventions: COMBINATION_PRODUCT: Endourage Targeted Wellness Formula C™, a full hemp flower extract
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility Study of Phase-contrast MRI for Flow in the External Carotid Branches Arteries
Status: RECRUITING
Conditions: Carotid Artery, External
Interventions: DEVICE: Magnetic Resonance Imaging (MRI),
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Osteoporosis and Fall Prevention and Posture Correction Interventions in the Metropolitan Area
Status: COMPLETED
Conditions: Osteoporosis Fracture
Interventions: BEHAVIORAL: ICG|BEHAVIORAL: MTG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Open-label Treatment Extension Study for Patients Who Complete Study RNA200103-201
Status: TERMINATED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: pradefovir mesylate|DRUG: adefovir dipivoxyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Renin-angiotensin System Blockers on Glomerular Filtration Rate in Patients With Hypertension, Type 2 Diabetes With Normoalbuminuria
Status: UNKNOWN
Conditions: Diabetes|Hypertensive Disease
Interventions: DRUG: Renin-angiotensin system blockers|DRUG: non-renin angiotensin system blockers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Single Versus Multicenter Outcomes for Pelvic Organ Prolapse Repair Using a Mesh-capturing Device
Status: COMPLETED
Conditions: Prolapse Genital
Interventions: DEVICE: Transvaginal mesh Uphold TM Vaginal Support System|DEVICE: Transvaginal mesh Uphold TM Vaginal Support System.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Progressive Resisted Exercise Plus Aerobic Exercise on Osteoporotic Systemic Lupus Erythmatosus
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: OTHER: Progressive resisted exercise training|DRUG: Calcium and Vit D|OTHER: Aerobic exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT