pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Sexual Health Advocacy for Guys - a Text Messaging-based HIV Prevention Program for Guys Who Are Into Guys
Status: RECRUITING
Conditions: HIV Infections
Interventions: BEHAVIORAL: Sexual health advocacy for guys|BEHAVIORAL: Healthy lifestyle control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Artificial Pancreas and Remote Monitoring During a T1DM Youth Ski Camp
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Tandem t:slim X2 with Control-IQ Technology + Dexcom G6|DEVICE: Dexcom CGM G5|DEVICE: Continuous Subcutaneous Insulin Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Intermittent Theta Burst Stimulation in Addition to Constraint-Induced Movement Therapy in Stroke Patients
Status: COMPLETED
Conditions: Stroke, Ischemic
Interventions: OTHER: Rehabilitation (modified constraint-induced movement therapy)|OTHER: non-invasive brain stimulation (intermittent theta-burst stimulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Sodium Retention in Liver Cirrhosis With Dexamethasone
Status: TERMINATED
Conditions: Liver Cirrhosis
Interventions: DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Effects of Variety and Portion Size on Meal Intake of Women
Status: WITHDRAWN
Conditions: Eating Behavior
Interventions: OTHER: Sequential Variety|OTHER: Simultaneous Variety|OTHER: Single Food|OTHER: Small portion|OTHER: Large Portion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Imatinib Mesylate in Treating Patients With Relapsed or Refractory Solid Tumors of Childhood
Status: COMPLETED
Conditions: Childhood Desmoplastic Small Round Cell Tumor|Childhood Synovial Sarcoma|Gastrointestinal Stromal Tumor|Lung Metastases|Recurrent Childhood Soft Tissue Sarcoma|Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Recurrent Neuroblastoma|Recurrent Osteosarcoma
Interventions: DRUG: imatinib mesylate|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Performance of Two Designs of Soft Toric Lenses
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Investigational Toric Lens|DEVICE: PureVision Toric Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Bezafibrate Trial in CPT2 Deficiency
Status: UNKNOWN
Conditions: Carnitine Palmitoyl Transferase 2 Deficiency
Interventions: DRUG: bezafibrate (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RiSPECT: Risperdal Safety Protocol Evaluation Consta Treatment, a Post Authorization Safety Survey to Obtain Information on the Safety and Efficacy of Risperidone When Used in Routine Clinical Practice
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders|Schizoaffective Disorder
Interventions: DRUG: Open label risperidone long acting injectable
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Testing AZD9291 as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH-Subprotocol E)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Hematopoietic and Lymphoid Cell Neoplasm|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Multiple Myeloma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Echocardiography|PROCEDURE: Multigated Acquisition Scan|DRUG: Osimertinib|PROCEDURE: Radiologic Examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of the FluidVision Accommodating Intraocular Lens (AIOL)
Status: COMPLETED
Conditions: Aphakia
Interventions: DEVICE: FluidVision AIOL|PROCEDURE: Cataract Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Programme Using a Mobile Application Versus Phone Advice on Patients at Risk of Coronary Heart Disease - A RCT
Status: UNKNOWN
Conditions: Coronary Heart Disease
Interventions: DEVICE: App group|DEVICE: Nursing telephone advice (NTA) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pramipexole Pilot Phase II Study in Children and Adolescents With Tourette Disorder According to DSM-IV Criteria
Status: COMPLETED
Conditions: Tourette Syndrome
Interventions: DRUG: pramipexole immediate release (IR)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-Dose Post-Transplant Cyclophosphamide, Bortezomib and Abatacept for the Prevention of Graft-versus-Host-Disease (GvHD) Following Allogenic Hematopoietic Stem Cell Transplantation (HSCT) Study
Status: RECRUITING
Conditions: Graft-versus-host Disease
Interventions: DRUG: Cyclophosphamide|DRUG: Abatacept|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intravenous Levetiracetam in Neonatal Seizures
Status: COMPLETED
Conditions: Neonatal Seizures
Interventions: DRUG: Intravenous levetiracetam|DRUG: Intravenous phenobarbital
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phonation Therapy to Improve Symptoms and Lung Physiology in Patients Referred for Pulmonary Rehabilitation
Status: WITHDRAWN
Conditions: COVID-19
Interventions: BEHAVIORAL: Tonation Breathing Techniques|BEHAVIORAL: Music Driven Vocal Exercises|BEHAVIORAL: Silent Breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DermaClose DUKE Fasciotomy and Wound Study
Status: RECRUITING
Conditions: Wound of Skin
Interventions: DEVICE: DermaClose Continuous External Tissue Expander Device|DEVICE: DermaClose XL Continuous External Tissue Expander Device|DEVICE: Conventional wound dressings
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Vakum Technology in Patients With Chronic Hypersecretion
Status: UNKNOWN
Conditions: Chronic Bronchitis/Bronchiectasis|Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: VAKÜM system|OTHER: conventional manual ELTGOL technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Induction Treatment of Proliferative Lupus Nephritis With Leflunomide Combined With Prednisone
Status: COMPLETED
Conditions: Nephritis, Lupus
Interventions: DRUG: leflunomide combined with prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fascia Iliaca Compartment Block and iPACK Block in Total Knee Arthroplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Arthropathy of Knee|Analgesia
Interventions: PROCEDURE: no peripheral block|PROCEDURE: Fascia Iliaca Compartment Block|PROCEDURE: iPACK Block
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Study of Gevokizumab to Treat Behcet's Disease Uveitis
Status: TERMINATED
Conditions: Behcet's Disease Uveitis
Interventions: DRUG: Placebo|DRUG: Gevokizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NIR Fluorescence Imaging of Lymphatic Transport Using ICG
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Indocyanine Green|DEVICE: MultiSpectral Imaging System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of M5049 in DM and PM Participants (NEPTUNIA)
Status: RECRUITING
Conditions: Dermatomyositis|Polymyositis
Interventions: DRUG: M5049 high dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Oropharyngeal Administration of Colostrum in the First 48 Hours of Life Term Premature Newborn ≤ 32 Weeks of Amenorrhea
Status: COMPLETED
Conditions: Infant, Premature
Interventions: BIOLOGICAL: Colostrum feeding|BIOLOGICAL: formula for preterm infants
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: To Assess the Effect of HDF Versus High Flux Dialysis on Free Light Chains and Cumulative Albumin Loss, in End Stage Renal Disease Patients.
Status: COMPLETED
Conditions: End Stage Renal Disease|Hemodiafiltration|Hemodialysis
Interventions: DEVICE: BIOPURE 260HF dialyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Markers of Iron Metabolism and Their Relationship With Phosphocalcic and Hepatic Metabolism and Inflammation in Hemodialysis Patients
Status: RECRUITING
Conditions: Iron Metabolism Disorders|Calcium Phosphate Metabolism|Hepatic Metabolic Disorders|Hemodialysis Complication
Interventions: PROCEDURE: Blood test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Continuation Trial for Subjects With Lupus Who Completed Protocol HGS1006-C1056 in the United States
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: Belimumab 1 mg/kg|BIOLOGICAL: Belimumab 10 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Anastomosis Sleeve Iejenal Bypass in Obese Patient With Hiatus Hernia
Status: COMPLETED
Conditions: Obesity, Morbid
Interventions: OTHER: Single anastomosis sleeve jejunal bypass with hiatal repair
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Normal Saline Versus Heparinized Solution Flush for Maintaining Patency of Peripheral Venous Catheters in Children
Status: SUSPENDED
Conditions: Infection of Intravenous Catheter|Phlebitis|Extravasation of Diagnostic and Therapeutic Materials
Interventions: DRUG: 0,9% NaCl flush|DRUG: Heparin 50U/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Chronotherapy on Blood Pressure - Time of Intake of Blood Pressure Lowering Drugs
Status: RECRUITING
Conditions: Hypertension|Drug Therapy|Primary Health Care
Interventions: OTHER: Time of ordinary antihypertensive medication intake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PMCF Study on Monofocal Toric IOL (PODEYE TORIC)
Status: COMPLETED
Conditions: Cataract|Lens Opacities|Astigmatism
Interventions: DEVICE: IOL implantation experimental
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Label Pharmacokinetic Study of Naftin for Tinea Corporis
Status: COMPLETED
Conditions: Tinea Corporis
Interventions: DRUG: Naftin® Cream, 2% (younger pediatric cohort)|DRUG: Naftin® Cream, 2% (older pediatric cohort)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EXCEL: Exercise for Cognition and Everyday Living for Seniors With Memory Complaints
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Exercise program (AT)|BEHAVIORAL: Exercise training (RT)|BEHAVIORAL: Exercise training (S & R; control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Phase 1 Study of PV-10 Chemoablation of Neuroendocrine Tumours (NET) Metastatic to the Liver
Status: ACTIVE_NOT_RECRUITING
Conditions: Neuroendocrine Tumors Metastatic to the Liver
Interventions: DRUG: Rose bengal disodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of an Anti-obesity Drug, Semaglutide, as Treatment in New-onset Idiopathic Intracranial Hypertension (IIH) Compared to Standard Weight Management (Dietician) With Regards to Change in Weight and Intracranial Pressure
Status: RECRUITING
Conditions: Idiopathic Intracranial Hypertension|Intracranial Pressure|Obesity|Pseudotumor Cerebri Syndrome|Papilledema|Weight Loss
Interventions: DRUG: Semaglutide|DIETARY_SUPPLEMENT: Very Low Calorie Diet|BEHAVIORAL: Dietician counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cryoanalgesia to Treat Post-Amputation Phantom Limb Pain: A Department of Defense Funded Multicenter Study
Status: COMPLETED
Conditions: Post-Amputation Phantom Limb Pain
Interventions: DEVICE: Cryoneurolysis|DEVICE: Sham Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aflibercept and 5-FU vs. FOLFOX as 1st Line Treatment for Elderly or Frail Elderly Patients With Met. Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Aflibercept + mLV5FU2|DRUG: mFOLFOX7
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Busulfan Monotherapy as Conditioning for Autologous Hematopoietic Progenitor Cell Transplantation
Status: TERMINATED
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: G-CSF|DRUG: Leukapheresis|DRUG: Busulfan|PROCEDURE: Stem cell reinfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dexmedetomidine in Topical Versus Peribulbar Anesthesia for Cataract Surgery
Status: RECRUITING
Conditions: Dexmedetomidine|Cataract Surgery|Peribulbar|Anesthesia
Interventions: DRUG: Topical dexmedetomidine|DRUG: Reginal dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Buprenorphine for Prisoners
Status: COMPLETED
Conditions: Heroin Addiction
Interventions: DRUG: Buprenorphine +OTP|DRUG: Buprenorphine +CHC|DRUG: Counseling +OTP|DRUG: Counseling +CHC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Colon Transit Study for Chronic Constipation Assessment and Therapy by Biofeedback With and Without TENS
Status: NOT_YET_RECRUITING
Conditions: Constipation
Interventions: OTHER: Biofeedback with TENS|OTHER: Biofeedback only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of the Optimal Dose of Tofacitinib Needed to Achieve Low Disease Activity (LDA) or Clinical Remission in Patients With Active Rheumatoid Arthritis (RA) as Measured From a Clinical and Structural Perspective
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treating Co-Occurring Substance Use and Mental Disorders Among Jail Inmates
Status: TERMINATED
Conditions: Co-occurring Mental and Substance Use Disorders|Crime|Criminogenic Thinking|Implementation|Adaptation
Interventions: BEHAVIORAL: Dual-diagnosis motivational interviewing (DDMI)|BEHAVIORAL: Integrated group therapy (IGT)|BEHAVIORAL: Jail and community-based behavioral health services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radial Extracorporeal Shock Wave Therapy in the Treatment of Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: DEVICE: splint and home exercise|DEVICE: RESWT|DEVICE: physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Suppression of Bone Turnover Following Treatment With Zoledronic Acid in Patients With Metastatic Breast Cancer: Duration of Effect
Status: COMPLETED
Conditions: Metastatic Breast Cancer With Bone Involvement
Interventions: DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A First-In-Human Study With a Single Dose UCB4019 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: PR1|OTHER: PL1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intraoperative Magnesium Sulfate Administration During Orthotopic Liver Transplantation
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: isotonic saline|DRUG: Magnesium Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Conventional Hemodialysis vs. Short Daily Hemodialysis (6 Days / Week) and Mechanisms of Blood Pressure Control
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: PROCEDURE: Microneurography|PROCEDURE: Bioimpedance testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Ciprofloxacin in Healthy Adult Subjects Under Fasting Condition
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Ciprofloxacin 750 mg|DRUG: Ciproxin 750 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Leveraging Electronic Health Record (EHR) Tools to Reduce Health Disparities for Patients With Uncontrolled Hypertension
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension|Blood Pressure
Interventions: BEHAVIORAL: REDUCE-BP Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the T Cell Response to a Peptide-based Vaccine in Patients With Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: BIOLOGICAL: 9 Peptides from Her-2/neu, CEA, & CTA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study: Post-Recovery LibEration From Oxygen in Exacerbated COPD
Status: WITHDRAWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: Rescind home oxygen order|BEHAVIORAL: Provider Education|BEHAVIORAL: Patient Education|BEHAVIORAL: Teach-to-goal inhaler training|BEHAVIORAL: Pursed lip breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Inflammation and Thrombosis in Patients With Severe Aortic Stenosis After Transcatheter Aortic Valve Replacement (TAVR)
Status: COMPLETED
Conditions: Aortic Stenosis|Inflammation|Thrombosis
Interventions: DRUG: Clopidogrel|DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Randomized Trial Of PF-00299804 Taken Orally Versus Erlotinib Taken Orally For Treatment Of Advanced Non-Small Cell Lung Cancer That Has Progressed After One Or Two Prior Chemotherapy Regimen
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Erlotinib|DRUG: PF-00299804
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ABX Combined With Cisplatin Compared With Gemcitabine Combined With Cisplatin in NSCLC
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: ABX Combined With Cisplatin|DRUG: Gemcitabine Combined With Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety Study of Dabigatran and Warfarin to Non-valvular Atrial Fibrillation Patients
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DRUG: standard intensity warfarin|DRUG: low intensity warfarin|DRUG: dabigatran etexilate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Emicizumab Administered Subcutaneously (SC) in Pediatric Participants With Hemophilia A and Factor VIII (FVIII) Inhibitors
Status: COMPLETED
Conditions: Hemophilia A
Interventions: DRUG: Emicizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Indocyanine-green Mediated Photosensitizer VS Aloe Vera Gel: Adjunct Therapy to Scaling and Root Planing in Patients With Chronic Periodontitis
Status: COMPLETED
Conditions: Periodontitis|Periodontal Inflammation
Interventions: COMBINATION_PRODUCT: Plant extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen
Status: COMPLETED
Conditions: Acute Liver Failure
Interventions: DRUG: N-acetylcysteine (NAC)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel/Prednisone Versus Docetaxel/Prednisone and Enzalutamide in Castration-Resistant Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Docetaxel|DRUG: Enzalutamide|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photobiomodulation Therapy on Performance in Successive Cycling Tests
Status: COMPLETED
Conditions: Photobiomodulation Therapy|Cyclists|Performance
Interventions: DEVICE: Photobiomodulation Therapy|DEVICE: Placebo Photobiomodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Feasibility Study of Adjuvant Treatment With S-1 in Patients After R0-Resection of Adenocarcinoma of the Stomach and Esophagogastric Junction
Status: COMPLETED
Conditions: Adenocarcinoma,Stomach|Adenocarcinoma, Esophagogastric Junction
Interventions: DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Walnuts on Central Blood Pressure, Arterial Stiffness Indices, Lipoproteins, and Other CVD Risk Factors
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: OTHER: Walnut Diet|OTHER: Walnut Control Diet|OTHER: Low ALA Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Magnesium in Liver Cirrhosis
Status: UNKNOWN
Conditions: LIVER CIRRHOSIS
Interventions: DIETARY_SUPPLEMENT: magnesium|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Instant Tooth Whitening Effect of a Silica Toothpaste Containing Blue Covarine
Status: COMPLETED
Conditions: Tooth Whitening
Interventions: OTHER: Blue covarine toothpaste|OTHER: Control toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness Investigation for Dry, Non-Exudative Age Related Macular Degeneration (AMD) Using Rheopheresis
Status: SUSPENDED
Conditions: Age-Related Maculopathy
Interventions: DEVICE: Rheopheresis|DEVICE: Rheopheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of the Use of Ozone Versus Sunflower Oil in Treating Diabetic Foot
Status: UNKNOWN
Conditions: Diabetes Mellitus
Interventions: OTHER: sunflower oil|OTHER: Ozone Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Angiojet Rheolytic Thrombectomy in Case of Massive Pulmonary Embolism
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: DEVICE: ANGIOJET RHEOLYTIC THROMBECTOMY
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation Study: Mobile DSST on Cognition in Adults With MDD
Status: COMPLETED
Conditions: Major Depressive Episode
Interventions: OTHER: Pen and Paper Digit Symbol Substitution Test (DSST)|OTHER: Electronic Digit Symbol Substitution Test (DSST)- (a.k.a. Codebreaker)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Multiple Oral Bedtime Doses of ORMD-0801 in Adult Patients With Type 2 Diabetes Mellitus (T2DM)
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: ORMD-0801 Dose # 1|DRUG: ORMD-0801 Dose # 2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Sedation With Remimazolam Besylate in Critically Ill Patients
Status: RECRUITING
Conditions: Light Sedation|Mechanical Ventilation
Interventions: DRUG: Remimazolam besylate|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety/Efficacy of Nepafenac Punctal Plug Delivery System Compared to Placebo to Control Ocular Pain/Inflammation After Cataract
Status: COMPLETED
Conditions: Pain|Inflammation
Interventions: COMBINATION_PRODUCT: Nepafenac PPDS|COMBINATION_PRODUCT: Placebo PPDS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Total Knee Prosthesis With Continuous Block of Adductor Canal and Outcome
Status: WITHDRAWN
Conditions: Total Knee Arthroplasty
Interventions: PROCEDURE: Adductor canal|PROCEDURE: Femoral|PROCEDURE: Spinal Anesthesia|PROCEDURE: Local anesthetic infusion|PROCEDURE: Intravenous analgesia|DRUG: Ropivacaine 0,75%|DRUG: Levobupivacaine 0,5%|DRUG: Levobupivacaine 0,125%|DRUG: Ketorolac 30mg|DRUG: Morphine|DEVICE: stimulong sono, Pajunk, Germany
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pioglitazone on Neointima Volume and Characteristics Observed by Optical Coherence Tomography (OCT)
Status: COMPLETED
Conditions: Diabetic Stable Angina|Diabetic Unstable Angina
Interventions: DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Feasibility and Effectiveness of Using a Smartphone Application During Rehabilitation in Patients After Total Knee Replacement
Status: COMPLETED
Conditions: Total Knee Replacement|Total Knee Arthroplasty
Interventions: DEVICE: Mobile application|OTHER: Standard rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety and Efficacy of JWCAR029 in Adult Subjects With Relapsed and Refractory B-cell Non-Hodgkin Lymphoma
Status: UNKNOWN
Conditions: Non Hodgkin Lymphoma
Interventions: BIOLOGICAL: JWCAR029
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Qualia NAD+ Supplementation on Intracellular NAD Levels
Status: RECRUITING
Conditions: NAD+ Levels in the Blood
Interventions: DIETARY_SUPPLEMENT: Qualia NAD+|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Mechanism of Action of Milk and Its Components on Glycemic Control in Healthy Young Men
Status: COMPLETED
Conditions: Glycemic Control|Gastrointestinal Hormone Response|Healthy Young Men
Interventions: DIETARY_SUPPLEMENT: Milk Fat|DIETARY_SUPPLEMENT: Milk Protein|DIETARY_SUPPLEMENT: Lactose|OTHER: Whole milk (3.25% M.F.(|DIETARY_SUPPLEMENT: Simulated Milk Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: |Primary Purpose: PREVENTION
Clinical trial: Evaluation of Oxaliplatin and Gemcitabine in Patients With Metastatic Bladder Cancer
Status: TERMINATED
Conditions: Carcinoma, Transitional Cell
Interventions: DRUG: Oxaliplatin with Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mycophenolate Mofetil in Membranous Nephropathy
Status: COMPLETED
Conditions: Glomerulonephritis, Membranous
Interventions: DRUG: mycophenolate mofetil orally 1000 mg twice a day (BID)|DRUG: prednisone 0,5 mg/kg orally on alternate days|DRUG: intravenous (i.v.) methylprednisolone 1000 mg, total 9
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NOAC Therapy Guided by PARIS Risk Score and D-dimer in Patients With ACS After PCI
Status: RECRUITING
Conditions: Coronary Artery Disease|Percutaneous Coronary Intervention|Acute Coronary Syndrome
Interventions: DRUG: Aspirin + Clopidogrel + Rivaroxaban|DRUG: Aspirin + Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EFFECTS OF ABATACEPT on the Progression to Rheumatoid Arthritis(PALABA Study)
Status: ACTIVE_NOT_RECRUITING
Conditions: Palindromic Rheumatism, Wrist
Interventions: DRUG: Abatacept Injection|DRUG: hydroxycloroquina
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy Combination Study in Advanced Previously Treated Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer|Progression of Non-small Cell Lung Cancer|Non-small Cell Lung Cancer Recurrent
Interventions: DRUG: Docetaxel|BIOLOGICAL: Tergenpumatucel-L|DRUG: Indoximod
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 6 Weeks Treatment of Locally Advanced Breast Cancer With BIBW 2992 (Afatinib) or Lapatinib or Trastuzumab
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: lapatinib|DRUG: BIBW 2992|DRUG: trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-field Thoracic Magnetic Stimulation Increases Peripheral Oxygen Saturation Levels in COVID-19 Patients
Status: UNKNOWN
Conditions: COVID-19|Acute Respiratory Failure|Oxygen Deficiency
Interventions: DEVICE: Low-field thoracic magnetic stimulation (LF-ThMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Efficacy Evaluation of 2 Different Bowel Cleansing Preparations in Adult Subjects
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: HalfLytely with Bisacodyl Tablets Bowel Prep Kit|DRUG: HalfLytely - Reformulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Electrical Muscle Stimulation in Critically Ill Patients
Status: COMPLETED
Conditions: Critical Illness
Interventions: OTHER: Electrical muscle stimulation (EMS)|OTHER: Sham EMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Efficacy of Proellex® in Premenopausal Women With Symptomatic Uterine Fibroids
Status: TERMINATED
Conditions: Uterine Fibroids
Interventions: DRUG: Proellex|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Selenium Supplementation in Pregnancy
Status: COMPLETED
Conditions: Pregnancy|Infertility|Auto-immune Thyroiditis
Interventions: DIETARY_SUPPLEMENT: Selenium|OTHER: Sugar Pill Placebo|OTHER: Selenium + L-Thyroxine (LT4)|OTHER: Sugar Pill Placebo + L-Thyroxine (LT4)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Stem Cell Transplant in Treating Patients With Hematological Cancer or Other Disorders
Status: UNKNOWN
Conditions: Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Precancerous Condition
Interventions: BIOLOGICAL: anti-thymocyte globulin|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: fludarabine phosphate|DRUG: mycophenolate mofetil|PROCEDURE: nonmyeloablative allogeneic hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo-controlled Proof of Concept Study of Epelsiban in Women With Adenomyosis
Status: WITHDRAWN
Conditions: Adenomyosis
Interventions: DRUG: Epelsiban|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Observational Study in Localized Osteosarcoma
Status: RECRUITING
Conditions: Localized Osteosarcoma
Interventions: OTHER: Treatment of Osteosarcoma according the AIEOP/ISG OS 2021 recommendations (includes drugs, surgery, radiotherapy or any other received treatments)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Artemisone for the Treatment of Uncomplicated Falciparum Malaria in Western Cambodia
Status: WITHDRAWN
Conditions: Uncomplicated Falciparum Malaria
Interventions: DRUG: Artemisone/Mefloquine (AmiM3)|DRUG: Artesunate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deprexil in Subjects With Signs and Symptoms of Depression
Status: COMPLETED
Conditions: Depression
Interventions: DIETARY_SUPPLEMENT: Deprexil|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Insulin Resistance in Patients After Carotid Revascularization
Status: UNKNOWN
Conditions: Carotid Stenosis
Interventions: DRUG: Melatonin|OTHER: blank
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Analgesics on a Walking Model of Knee Pain (0000-105)(COMPLETED)
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Naproxen|DRUG: Placebo|DRUG: Ultracet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Virtual Reality Intervention Alleviates Dyspnea in Patients Recovering From COVID Pneumonia
Status: COMPLETED
Conditions: Covid19|Dyspnea
Interventions: DEVICE: COVVR_Synch|DEVICE: COVVR_Asynch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Re-operation Rate After Introduction of Evidence Based Algorithm for the Treatment of Ankle Fractures
Status: UNKNOWN
Conditions: Ankle Fractures|Surgery|Syndesmotic Injuries|Posterior Malleolus Fractures
Interventions: PROCEDURE: PRO-malleol algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy/Safety Study of Amaryl®M 1/500 mg Twice Daily Versus Amaryl® 4 mg Both in Combination With Lantus® in Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: glimepiride + insulin glargine (Amaryl + Lantus)|DRUG: glimepiride/metformin fixed combination+insulin glargine (AmarylM + Lantus)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bendamustine + Rituximab in Older Patients With Previously Untreated Diffuse Large B-cell Lymphoma
Status: COMPLETED
Conditions: Diffuse Large B-Cell Lymphoma|Lymphoma, Diffuse Large-Cell|Diffuse Large-Cell Lymphoma|Lymphoma
Interventions: DRUG: Bendamustine|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction Chemotherapy Followed by Surgery for Locally Advanced Head and Neck Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer
Interventions: DRUG: Cisplatinum|DRUG: Docetaxel|DRUG: Carboplatin|PROCEDURE: Transoral Robotic Assisted Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Lurbinectedin (PM01183) in Combination With Cisplatin in Patients With Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: lurbinectedin (PM01183)|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Varenicline-Methamphetamine Interaction Study (2008)
Status: WITHDRAWN
Conditions: Methamphetamine Dependence|Substance Abuse|Methamphetamine Abuse
Interventions: DRUG: Varenicline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Pharmacist-Driven Stress Ulcer Prophylaxis Minimization in the Intensive Care Unit
Status: COMPLETED
Conditions: Stress Ulcer
Interventions: BEHAVIORAL: To evaluate the effectiveness and safety of a pharmacist-driven protocol to discontinue stress ulcer prophylaxis in ICU patients when it is no longer indicated according to pre-defined criteria.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PD P 506 A-PDT Versus Placebo-PDT and Cryosurgery for the Treatment of AK
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: PROCEDURE: Photodynamic Therapy|PROCEDURE: Cryosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adaptation and Evaluation of the PMTCT CSC in Dedza and Ntcheu Districts, Malawi
Status: COMPLETED
Conditions: HIV/AIDS|Infant Morbidity
Interventions: BEHAVIORAL: Community score card approach
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact of Two Genetic Variants of OATP1B3 or MRP2 or Rifampin on Systemic Disposition and Biological Efficacy of CCK-8
Status: COMPLETED
Conditions: Gastrointestinal Hormones
Interventions: DIETARY_SUPPLEMENT: mixed meal|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of ThermoProfen in Patients With Mild to Moderate Pain Associated With Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: ThermoProfen™ (Matrix Transdermal Ketoprofen/CHADD™ System)|DRUG: Placebo Matrix/CHADD Patch|DRUG: Ketoprofen matrix/placebo CHADD Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety And Effectiveness Of Daily Dosing With Sunitinib Or Imatinib In Patients With Gastrointestinal Stromal Tumors
Status: TERMINATED
Conditions: Gastrointestinal Stromal Tumor
Interventions: DRUG: sunitinib malate|DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety and Efficacy Study of Deucravacitinib in Participants With Systemic Lupus Erythematosus
Status: ACTIVE_NOT_RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: BMS-986165
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mid-Infrared Spectroscopy as a Real Time Diagnostic Tool for Chronic Endometritis
Status: UNKNOWN
Conditions: Endometritis|IVF
Interventions: PROCEDURE: Hysteroscopy|DEVICE: Infrared Spectroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dysport® Adult Lower Limb Spasticity Follow-on Study
Status: COMPLETED
Conditions: Post-stroke Spasticity|Spasticity Post-Traumatic Brain Injury
Interventions: BIOLOGICAL: Botulinum toxin type A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: cSEMS vs. NEPS in Stricture of Biliary Anastomosis After Liver Transplantation
Status: COMPLETED
Conditions: Stenosis of the Bilio-biliary Anastomosis After Orthotopic Liver Transplantation
Interventions: DEVICE: Non-expandable plastic stent (plastic endoprosthesis)|DEVICE: Covered self-expandable metal stent (cSEMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of DSCT With IB-IVUS and Angiography in the Assessment of Coronary Artery Disease
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Integrated Backscatter IVUS|DEVICE: Dual Source Computed Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Aerosol Combination Therapy of All-trans Retinoic Acid and Isotretinoin as A Novel Treatment for Inducing Neutralizing Antibodies in COVID -19 Infected Patients Better Than Vaccine : An Innovative Treatment
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Aerosolized 13 cis retinoic acid|DRUG: Aerosolized All trans retinoic acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Smoking and Its Cessation on Systemic and Airway Immune Activation
Status: COMPLETED
Conditions: HIV|Smoking
Interventions: BEHAVIORAL: Counseling|OTHER: Smoking Cessation drugs|PROCEDURE: Bronchoscopy|PROCEDURE: Blood Draw|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vasodilator-induced Hypovolemia in Living Liver Donors
Status: COMPLETED
Conditions: CVP and SVV During Living Donor Hepatectomy|Surgical Field Grade (Condition of Surgical Field; Bleeding, Tension of the IVC)
Interventions: PROCEDURE: vasodilator induced hypovolemia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Corneal Cross-linking and Refractive Surface Ablation in Patients With Asymmetric Corneas
Status: COMPLETED
Conditions: Surgical Procedure, Unspecified
Interventions: PROCEDURE: CXL + PRK group|PROCEDURE: PRK group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT