pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparison of the Shukla and UN-1 Formulae in the Placement of the Umbilical Venous Catheter Among Neonates
Status: COMPLETED
Conditions: Extreme Prematurity,Extremely Low Birthweight|Extremely Low Birth Weight|Very Low Birth Weight Infant|Neonatal Hypoglycemia
Interventions: PROCEDURE: UVC insertion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Online Self-management in Hand Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis|Musculoskeletal Diseases|Rheumatic Diseases|Arthritis|Joint Diseases
Interventions: BEHAVIORAL: Online self-management intervention|OTHER: Care-as-usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Discoloration of Endosequence and Mineral Trioxde Aggregate in Revascularization of Necrotic Immature Permanent Teeth
Status: NOT_YET_RECRUITING
Conditions: Pulp Necrosis
Interventions: OTHER: Revascularization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Training Set for the HRD Model in EOC
Status: UNKNOWN
Conditions: Epithelial Ovarian Cancer|BRCA Mutation|Loss of Heterozygosity|Prognosis|Platinum Resistance|Homologous Recombination Deficiency
Interventions: GENETIC: Homologous recombination deficiency model
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety and Effectiveness of Asoprisnil in the Treatment of Women With Endometriosis.
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: Asoprisnil|DRUG: Asoprisnil|DRUG: Asoprisnil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function
Status: UNKNOWN
Conditions: Ischemic Heart Disease|Microvascular Coronary Artery Disease|Diastolic Dysfunction|Heart Failure With Preserved Ejection Fraction
Interventions: DIAGNOSTIC_TEST: Echocardiography|DIAGNOSTIC_TEST: Coronary flow reserve and index of microcirculatory dysfunction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety and Tolerability Study of Human Forebrain Neural Progenitor Cells Injection (hNPC01) in Subjects With Chronic Ischemic Stroke
Status: RECRUITING
Conditions: Chronic Ischemic Stroke
Interventions: DRUG: hNPC01
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Fractional Flow Reserve in Renal Artery Stenting
Status: COMPLETED
Conditions: Renal Artery Stenosis|Hypertension
Interventions: PROCEDURE: Renal artery stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Financial Difficulty in Participants With Chronic Lymphocytic Leukemia and Multiple Myeloma
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Plasma Cell Myeloma
Interventions: OTHER: Medical Chart Review|OTHER: Interview|OTHER: Questionnaire|OTHER: Quality-of-Life Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hydroxychloroquine (HCQ) as Post Exposure Prophylaxis (PEP) for Prevention of COVID-19
Status: UNKNOWN
Conditions: Covid19|COVID-19 Prevention
Interventions: DRUG: Hydroxychloroquine (HCQ)|OTHER: Standard care|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Allogeneic HCT Using Nonmyeloablative Host Conditioning With TLI & ATG vs SOC in AML
Status: TERMINATED
Conditions: Leukemia, Myeloid|Leukemia|Acute Myeloid Leukemia (AML)
Interventions: PROCEDURE: Allogeneic HSCT|DRUG: Anti-thymocyte globulin (ATG)|DRUG: Cyclosporine (CSP)|DRUG: Mycophenolate mofetil (MMF)|RADIATION: Total lymphoid irradiation (TLI)|DRUG: Methylprednisolone sodium succinate|DRUG: Best standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patienthèque of Finisterian (South of Brittany) Children With Cystic Fibrosis in the Time of Precision Medicine
Status: RECRUITING
Conditions: Cystic Fibrosis
Interventions: DIAGNOSTIC_TEST: collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Single Agent Pembrolizumab in Subjects With Advanced Adrenocortical Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Adrenocortical Carcinoma
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MW151-101: First-in-human Study of MW151
Status: COMPLETED
Conditions: Drug Toxicity
Interventions: DRUG: Placebo|DRUG: MW151, 10mg|DRUG: MW151, 20mg|DRUG: MW151, 40mg|DRUG: MW151, 80mg|DRUG: MW151, 160mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of the Immune Response to Clostridium Difficile in Adults With Clostridium Difficile Infection (CDI)
Status: COMPLETED
Conditions: Infections, Clostridium Difficile
Interventions: PROCEDURE: Blood sampling|OTHER: Stool sample collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: REBUILD-SM Study for People With Interstitial Lung Disease (ILD)
Status: RECRUITING
Conditions: Lung Diseases, Interstitial|Pulmonary Fibrosis
Interventions: BEHAVIORAL: Pulmonary Fibrosis self-management package and smartphone application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Retinal Sensitivity in BRVO After Anti-VEGF Therapy
Status: UNKNOWN
Conditions: Branch Retinal Vein Occlusion
Interventions: DRUG: Ranibizumab|DRUG: Ranibizumab and laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Epley-Canalith Repositioning Procedure and Vestibular Rehabilitation Therapy in Diabetic Patients With BPPV
Status: COMPLETED
Conditions: Benign Paroxysmal Positional Vertigo
Interventions: OTHER: Epley-Canalith Repositioning|OTHER: Vestibular Rehabilitation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Find Out if ASP5354 Can Clearly Help Show the Ureter During Surgery
Status: RECRUITING
Conditions: Intraoperative Ureter Visualization|Abdominolpelvic Surgery
Interventions: DRUG: pudexacianinium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lidocaine Reduces Muscle Tremor is Beneficial for Intraoperative Recurrent Laryngeal Nerve Monitoring
Status: UNKNOWN
Conditions: Thyroid Cancer|Neck Cancer|Recurrent Laryngeal Nerve Injuries|Accessory Nerve Injuries|EMG: Repetitive Nerve Stimulation Abnormality
Interventions: DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Neurocognitive and Supportive Therapy Interventions for Individuals With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease|Mild Cognitive Impairment
Interventions: BEHAVIORAL: Memory and Problem-Solving Intervention|BEHAVIORAL: Supportive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Ruptured Intracranial Aneurysms in China.
Status: UNKNOWN
Conditions: Ruptured Intracranial Aneurysms|Unruptured Intracranial Aneurysms|Stent-Assisted Coiling|Non-Stent-Assisted Coiling|Craniotomy Clipping
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: K-HEARS MCI: Hearing Health Care for Korean American Older Adults With Mild Cognitive Impairment
Status: RECRUITING
Conditions: Age-related Hearing Impairment|Personal Communication|Mild Cognitive Impairment
Interventions: BEHAVIORAL: K-HEARS Intervention|DEVICE: K-HEARS Sound Amplifier Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase 1 Study of TRS005 in Patients With R/R CD20-positive B-NHL.
Status: RECRUITING
Conditions: CD20-positive B-cell Non-Hodgkin Lymphoma
Interventions: DRUG: Recombinant CD20 monoclonal antibody-MMAE conjugte for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pragmatic Randomized Controlled Trial of Chinese Herbal Medicine for Severe Pandemic H1N1 Influenza
Status: UNKNOWN
Conditions: Influenza A Virus, H1N1 Subtype
Interventions: DRUG: Chinese herbal medicines plus western therapy|DRUG: western therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Real World Study of eCoin for Urgency Urinary Incontinence: Post Approval Evaluation (RECIPE)
Status: RECRUITING
Conditions: Overactive Bladder|Urge Incontinence|Incontinence, Urinary|Urinary Urge Incontinence
Interventions: DEVICE: eCoin Tibial Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of FIFA 11+ Kids Injury Prevention Program on Soccer-specific Skills Among Young Soccer Players
Status: NOT_YET_RECRUITING
Conditions: Healthy Young Soccer Players
Interventions: OTHER: FIFA 11+ KIDS PROGRAM|OTHER: REGULAR TRAINING
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Implementation of Lung Cancer Screening in the First Line Zone of ZORA (Flanders), Using a Low Dose CT-scan
Status: ENROLLING_BY_INVITATION
Conditions: Lung Cancer, Nonsmall Cell|Lung Cancer|Smoking Cessation|Lung Cancer, Small Cell
Interventions: RADIATION: Low-dose CT scan|BEHAVIORAL: Smoking Cessation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: The HistoSonics System for Treatment of Primary and Metastatic Liver Tumors Using Histotripsy
Status: ACTIVE_NOT_RECRUITING
Conditions: Liver Neoplasms|Hepatocellular Carcinoma|Liver Metastases
Interventions: DEVICE: HistoSonics System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CVM-1118 for Patients With Advanced Neuroendocrine Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Neuroendocrine Tumors|Pancreatic Neuroendocrine Tumor|Gastro-enteropancreatic Neuroendocrine Tumor|Lung Neuroendocrine Neoplasm|Neuroendocrine Carcinoma
Interventions: DRUG: CVM-1118
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simplified GBS Screening and Prevalence of ESBL in Pregnant Women
Status: COMPLETED
Conditions: Group B Streptococcal Infection|Infection Due to ESBL Bacteria
Interventions: OTHER: vagino-perineal swab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Comparison of Subvastus and Midvastus Approaches in Minimally-Invasive Total Knee Arthroplasty
Status: COMPLETED
Conditions: Total Knee Arthroplasty
Interventions: PROCEDURE: mini-midvastus surgical approach for total knee arthroplasty|PROCEDURE: mini-subvastus surgical approach for total knee arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Testing Use of Condoms on Regression of Cervical Intraepithelial Neoplasia
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia
Interventions: BEHAVIORAL: Advice to use condoms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of TACI-antibody Fusion Protein Injection (RC18) in Healthy Adult Chinese Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Tai Ai(RC18) 80mg|BIOLOGICAL: Tai Ai(RC18) 160mg|BIOLOGICAL: RC18 240mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer
Status: TERMINATED
Conditions: Cancer
Interventions: DRUG: cyclophosphamide|DEVICE: Cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Vigil™ + Pembrolizumab for Advanced Melanoma
Status: COMPLETED
Conditions: Melanoma Recurrent|Malignant Melanoma|Melanoma
Interventions: BIOLOGICAL: Vigil|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Stem Cells in Brain Injury
Status: COMPLETED
Conditions: Hypoxia-Ischemia, Cerebral|Cerebral Palsy
Interventions: PROCEDURE: Intrathecal Autologous Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of an Dendritic and Glioma Cells Fusion Vaccine With IL-12 for Treatment-naïve GBM Patients.
Status: UNKNOWN
Conditions: Glioblastoma|Glioma|Neoplasms, Neuroepithelial|Neuroectodermal Tumors|Neoplasms|Neoplasms, Nerve Tissue|Vaccines|Immunologic Factors
Interventions: BIOLOGICAL: Dendritic Cell/Tumor Fusion Vaccine|DRUG: Interleukin-12|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementing a Scalable Smoke-free Home Intervention in Armenia and Georgia
Status: NOT_YET_RECRUITING
Conditions: Second Hand Tobacco Smoke
Interventions: BEHAVIORAL: Smoke-free homes intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Radical Cystectomy: Can We Improve Our Surgical Technique With the Ligasure Impact Tissue-Sealing Device?
Status: TERMINATED
Conditions: Bladder Cancer|Hemostasis
Interventions: DEVICE: Stapling device during radical cystectomy|DEVICE: Ligasure tissue sealing device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sperm Selection by Microfluidic Separation Improves Embryo Quality
Status: COMPLETED
Conditions: Sperm DNA Fragmentation|Embryo Quality|Fertility Disorders|Infertility|Infertility, Male|Infertility Unexplained
Interventions: DEVICE: Microfluidic Sperm Sorting|PROCEDURE: in vitro fertilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Functional Abdominal Pain in Children: Evaluation of Relaxation/Guided Imagery and Chamomile Tea as Therapeutic Modalities
Status: COMPLETED
Conditions: Recurrent Abdominal Pain
Interventions: DRUG: chamomile tea|PROCEDURE: Relaxation/Guided Imagery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Behavioral Activation - From Inpatient to Outpatient Services
Status: COMPLETED
Conditions: Inpatient Facility Diagnoses|Psychiatric Disorders|Depressive Symptoms
Interventions: BEHAVIORAL: Behavioral Activation|BEHAVIORAL: Supportive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alternative Schedule Study For VLA15, a Vaccine Candidate Against Lyme Borreliosis
Status: COMPLETED
Conditions: Lyme Borreliosis
Interventions: BIOLOGICAL: VLA15|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Patient Versus Provider-led Titration of Insulin for Glycemic Control in Gestational Diabetes (EMPOWER)
Status: RECRUITING
Conditions: Gestational Diabetes Mellitus|Pregnancy in Diabetic|Pregnancy, High Risk
Interventions: DRUG: Patient-led Insulin (intervention group)|DRUG: Provider-led Insulin (standard care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: APPROACH 2.0: HIV, HCV and Syphilis Testing Through Pharmacies
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections|HCV Infection|Syphilis Infection
Interventions: OTHER: Choice of STBBI test(s)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Ibuprofen Versus Ibuprofen/Acetaminophen Postoperatively in Patients Needing Root Canal Therapy
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Ibuprofen 600 mg|DRUG: ibuprofen 600 mg and acetaminophen 650 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetes Self Management Education Programme in Thailand
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: A low-cost DSME program and scalable delivery model for roll-out within the Thai primary care system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intravenous Triple Therapy in the Treatment of Helicobacter Pylori Infection and Related Complications Caused by Active Peptic Ulcer Disease
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection|Intravenous Drug Usage
Interventions: DRUG: Esomeprazole|DRUG: Metronidazole|DRUG: Levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of CARE1.02 Spectacle Lens in Myopia Control
Status: ACTIVE_NOT_RECRUITING
Conditions: Myopia
Interventions: DEVICE: CARE1.02|DEVICE: Single-vision spectacle lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I Randomized Study of Adeno-Associated Virus-CFTR Vector in Patients With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Adeno-associated virus-CFTR vector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Modulating Stress-Reactivity by Real-Time Multimodal Functional Neuroimaging Based Neurofeedback
Status: UNKNOWN
Conditions: Stress|Pituitary-Adrenal System
Interventions: OTHER: Contingent RT-fMRI-NF|OTHER: Sham RT-fMRI-NF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Multi-centre Trial on Targeted Microwave Ablation (TMA) for Localized Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DEVICE: Targeted Microwave Ablation (TMA) for localized prostate cancer using organ based tracking (OBT) navigation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cryotherapy Versus Radiofrequency Catheter Ablation Research Program
Status: UNKNOWN
Conditions: Atrial Fibrillation|Atrial Tachycardia|Wpw|Ventricular Tachycardia
Interventions: PROCEDURE: Cryotherapy|PROCEDURE: radiofrequency catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma|GBM|Brain Neoplasms, Adult, Malignant|Brain Tumor
Interventions: DRUG: Niraparib|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Lassa Fever Vaccine Trial in Adults and Children Residing in West Africa
Status: RECRUITING
Conditions: Lassa Fever
Interventions: DRUG: Day 1 Lower Dose (2×106 pfu)|DRUG: Day 1 Higher Dose (1×107 pfu)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of GSK2831781 After an Intravenous (IV) Dose in Healthy Japanese and Caucasian Subjects, and a Subcutaneous (SC) Dose in Healthy Caucasian Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: GSK2831781|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Caspofungin to Placebo for the Treatment of ICU Intra-abdominal Candidiasis
Status: RECRUITING
Conditions: ICU Yeast Intra-abdominal Infection
Interventions: DRUG: caspofungin antifungal therapy|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Web-based Implementation for the Science of Enhancing Resilience Study
Status: COMPLETED
Conditions: Burnout, Professional|Resilience, Psychological
Interventions: BEHAVIORAL: Three Good Things|BEHAVIORAL: Gratitude|BEHAVIORAL: Random Acts of Kindess|BEHAVIORAL: Awe|BEHAVIORAL: 1 Good Chat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cells for Progressive Multiple Sclerosis_Sweden
Status: COMPLETED
Conditions: Autologous Mesenchymal Stem Cells|Multiple Sclerosis
Interventions: BIOLOGICAL: Autologous mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomised Study of Oral Azacitidine vs Placebo Maintenance in AML or MDS Patients After Allo-SCT
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplasia
Interventions: DRUG: Oral azacitidine|DRUG: Matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study of rhuFab V2 in Subjects With Neovascular Age-Related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: rhuFab V2 (ranibizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dried Blood Spot Sampling Method for Vancomycin and Creatinine Monitoring for OPAT
Status: RECRUITING
Conditions: Infection, Bacterial
Interventions: DIAGNOSTIC_TEST: Finger Prick|DIAGNOSTIC_TEST: Venipuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: 89Zr-DFO*-Trastuzumab PET in Patients With Gastric or Breast Cancer - a Pilot Study
Status: RECRUITING
Conditions: Breast Cancer|Metastatic Breast Cancer|HER2-positive Breast Cancer|Gastric Cancer|Metastatic Gastric Cancer|HER2-positive Gastric Cancer
Interventions: DIAGNOSTIC_TEST: 89Zr-DFO*-trastuzumab PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Assess Efficacy and Safety of Bulevirtide in Combination With Pegylated Interferon Alfa-2a in Participants With Chronic Hepatitis Delta (CHD)
Status: COMPLETED
Conditions: Chronic Hepatitis Delta
Interventions: DRUG: Bulevirtide|DRUG: Peginterferon Alfa-2a (PEG-IFN alfa)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cook Balloon Versus Propess After 12 Hours of Rupture of Membranes
Status: UNKNOWN
Conditions: PROM (Premature Rupture Of Foetal Membrane)
Interventions: DRUG: Propess® (dinoprostone)|DEVICE: cook cervical pipening balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Prucalopride For Functional Constipation in Children and Teenagers
Status: TERMINATED
Conditions: Constipation
Interventions: DRUG: Prucalopride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Ph 2 Trial With an Oral Tableted COVID-19 Vaccine
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: VXA-CoV2-1.1-S|OTHER: Placebo Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Airway Management Study to Evaluate the C-MAC Video Laryngoscope as an Alternative to the Direct Laryngoscopy
Status: COMPLETED
Conditions: Unexpected Difficult Airway
Interventions: DEVICE: Endotracheal intubation using the C-MAC video laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RC108 Combine With Furmonertinib With/Without Toripalimab in Patients With EGFR-mutated NSCLC
Status: RECRUITING
Conditions: NSCLC
Interventions: DRUG: RC108
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sildenafil Citrate on Mid Luteal Phase Uterine Artery Blood Flow in Patients With Recurrent Pregnancy Loss
Status: COMPLETED
Conditions: Recurrent Pregnancy Loss
Interventions: DRUG: Sildenafil 25Mg Tablet|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ph 1B B-701 in Combination With Pembrolizumab in Metastatic Transitional Cell Carcinoma of the Urothelial Tract
Status: TERMINATED
Conditions: Bladder Cancer
Interventions: DRUG: B-701|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hiatal Hernia Repair by Tension-free Mesh Closure or Simple Suturing
Status: COMPLETED
Conditions: Hiatal Hernia
Interventions: PROCEDURE: Hiatal hernia repair by tension-free mesh closure|PROCEDURE: Hiatal hernia repair by simple suturing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Pharmacotherapy for Bipolar Alcoholics
Status: COMPLETED
Conditions: Bipolar Disorder|Alcohol Dependence
Interventions: DRUG: Naltrexone hydrochloride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Dose IL-2 Therapy in Patients With a Depressive Episode in the Course of a Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Depression
Interventions: DRUG: ILT101|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tilsotolimod in Combo With Ipilimumab vs Ipilimumab Alone in Subjects With Anti-PD-1 Refractory Melanoma
Status: TERMINATED
Conditions: Metastatic Melanoma
Interventions: DRUG: Ipilimumab|DRUG: Tilsotolimod with Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of the Efficacy and Safety of CSF-1 in the Temporary Correction of Presbyopia (NEAR-1)
Status: COMPLETED
Conditions: Presbyopia
Interventions: DRUG: CSF-1|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ticagrelor Single Antiplatelet Therapy in Patients With High Risk of Bleeding After DCB for Coronary Small Vessel Disease
Status: NOT_YET_RECRUITING
Conditions: Coronary Heart Disease
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study of Advance Plasma Therapy001 Plasma/Nitric Oxide Therapy for the Treatment of Diabetic Foot Ulcers
Status: UNKNOWN
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: Standard of Care|DEVICE: Nitric Oxide Therapy 2x week 6 min. plus standard of care|DEVICE: Nitric Oxide Therapy 2x week 12 min. plus standard of care|DEVICE: Nitric Oxide Therapy 4x week 6 min. plus standard of care|DEVICE: Nitric Oxide Therapy 4x week 12 min. plus standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study of TQB2450 Injection in Subjects With PD-L1 Positive Recurrent or Metastatic Cervical Cancer
Status: UNKNOWN
Conditions: Recurrent or Metastatic Cervical Cancer
Interventions: DRUG: TQB2450
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quinine and Food Intake
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Quinine sham feeding quinine|DIETARY_SUPPLEMENT: Gastric quinine|DIETARY_SUPPLEMENT: Oral sham feeding placebo|DIETARY_SUPPLEMENT: Gastric placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Prospective Study to Compare the Efficacy of E.G.Scan to Detect Barrett's Esophagus Compared With Standard Endoscopy
Status: COMPLETED
Conditions: Barrett's Esophagus
Interventions: DEVICE: EG Scan II (transnasal endoscopy)|PROCEDURE: Standard Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Plyometric Exercises Versus Wii Training In Children With Unilateral Cerebral Palsy
Status: RECRUITING
Conditions: Sports Physical Therapy
Interventions: OTHER: Designed physical therapy|OTHER: Occupational therapy|OTHER: Plyometric training|OTHER: Wii training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Umbilical Cord Derived Mesenchymal Stem Cells Therapy in Hypoxic Ischemic Encephalopathy
Status: UNKNOWN
Conditions: Hypoxic Ischemic Encephalopathy
Interventions: BIOLOGICAL: mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Livionex on Reducing Plaque Accumulation and Improving Oral Health in Children
Status: COMPLETED
Conditions: Plaque, Dental|Caries, Dental|Oral Hygiene
Interventions: OTHER: Livionex Dental Gel|OTHER: A standard children's toothpaste containing 1500 ppm fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Radial Extracorporeal Shock Wave Therapy and Visual Feedback Balance Training on Lower Limb Post-Stroke Spasticity, Trunk Performance and Balance:
Status: ACTIVE_NOT_RECRUITING
Conditions: Stroke, Ischemic|Stroke Hemorrhagic|Spasticity as Sequela of Stroke|Spastic Gait|Balance; Distorted
Interventions: OTHER: radial extracorporeal shock wave therapy|OTHER: sham radial extracorporeal shock wave therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Hydroxychloroquine and Favipiravir in the Treatment of Mild to Moderate COVID-19
Status: UNKNOWN
Conditions: Sars-CoV2|COVID-19
Interventions: DRUG: Favipiravir (3200 mg + 1200 mg)|DRUG: Favipiravir (3600 mg + 1600 mg)|DRUG: Favipiravir (3200 mg + 1200 mg) combined with Hydroxychloroquine|DRUG: Favipiravir (3200 mg + 1200 mg) combined with Azithromycin|DRUG: Hydroxychloroquine|DRUG: Hydroxychloroquine combined with Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Food on the Pharmacokinetics (PK) of TAK-659 in Participants With Advanced Solid Tumor
Status: WITHDRAWN
Conditions: Lymphoma, Malignant|Advanced Solid Neoplasms
Interventions: DRUG: TAK-659
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Rec-LH PD and Safety Profile in Hypogonadotropic Hypogonadism Men
Status: RECRUITING
Conditions: Acquired Hypogonadotropic Hypogonadism
Interventions: DRUG: Lutropin alfa|DRUG: Human chorionic gonadotropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Venetoclax in Combination With Low-Dose Cytarabine in Treatment-Naïve Participants With Acute Myelogenous Leukemia
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|AML
Interventions: DRUG: Venetoclax|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quadratus Lumborum Block Versus Erector Spinae Block in Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Postoperative Analgesia
Interventions: PROCEDURE: nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Neu-Prem Trial: Neuromonitoring of Preterm Newborn Brain During Birth Resuscitation
Status: COMPLETED
Conditions: Neurologic Manifestations|Premature Birth|Hypoxia-Ischemia, Brain
Interventions: DEVICE: EEG|DEVICE: NIRS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Influence of Paracentesis on Intra-abdominal Pressure and Kidney Function in Critically Ill Patients With Liver Cirrhosis and Ascites: an Observational Study
Status: WITHDRAWN
Conditions: Critically Ill|Liver Cirrhosis|Ascites
Interventions: PROCEDURE: paracentesis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: IL- 6 Gene (174G/C) Single Nucleotide Polymorphism as an Indicator of COVID-19 Severity in Egyptian Patients
Status: COMPLETED
Conditions: Covid19
Interventions: DIAGNOSTIC_TEST: interleuken 6 level measurment|DIAGNOSTIC_TEST: Interleukin-6 Gene-174C detection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Suprachoroidal Injection of Triamcinolone Acetonide Using Custom Made Needle to Treat Retinal Disorders
Status: UNKNOWN
Conditions: Diabetic Macular Edema, Cystoid Macular Edema, Chorodial Neovascularzation, Posterior Uveitis
Interventions: PROCEDURE: Custom suorachoroidal needle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BETTER (Brain Injury Education, Training, and Therapy to Enhance Recovery)
Status: ENROLLING_BY_INVITATION
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: BETTER (Brain Injury, Education, Training, and Therapy to Enhance Recovery)|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Repeated Dose Phase I Study of FYU-981
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: FYU-981, (Oral daily dosing for 7 days)|DRUG: Placebo, (Oral daily dosing for 7 days)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of E7080 Alone, and in Combination With Everolimus in Subjects With Unresectable Advanced or Metastatic Renal Cell Carcinoma Following One Prior Vascular Endothelial Growth Factor (VEGF)-Targeted Treatment
Status: COMPLETED
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: Lenvatinib|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inter-semispinal Plane Block and Cervical Spine Surgery
Status: COMPLETED
Conditions: Post Operative Pain|Cervical Spine Instability
Interventions: DRUG: Bupivacaine Hydrochloride|DRUG: Lidocaine Hydrochloride|DEVICE: Ultrasound|DEVICE: Needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy, Safety and Tolerability of KAF156 in Combination With Lumefantrine Solid Dispersion Formulation (LUM-SDF) in Pediatric Population With Uncomplicated Plasmodium Falciparum Malaria
Status: RECRUITING
Conditions: Uncomplicated Plasmodium Falciparum Malaria
Interventions: DRUG: KAF156|DRUG: LUM-SDF|DRUG: Coartem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Injection HB0017 in Adult Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: HB0017|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A 3-month Cycle of Virtual Guided Tours to Promote Health in Older Community Members in a Context of COVID-19 Induced Social Isolation: a Pilot Study
Status: COMPLETED
Conditions: Social Isolation|Quality of Life|Well Aging|Frailty
Interventions: OTHER: Museum virtual guided tours
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Lopinavir/r/ Lamivudine/ Abacavir as an Easy to Use Paediatric Formulation
Status: UNKNOWN
Conditions: HIV
Interventions: DRUG: ABC/3TC/LPV/r granules (30/15/40/10 mgs)|DRUG: LPV/r Pellets (40/10mgs) plus ABC/3TC (60/30mgs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of Alpelisib With Everolimus or Alpelisib With Everolimus and Exemestane in Advanced Breast Cancer Patients, Renal Cell Cancer and Pancreatic Tumors
Status: COMPLETED
Conditions: Neoplasms|Breast Neoplasms|Kidney Neoplasms|Pancreatic Neuroendocine Neoplasms (pNETs)
Interventions: DRUG: alpelisib|DRUG: everolimus|DRUG: exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Evaluation and Mechanism Study of Ketogenic Diet on Autism Spectrum Disorder in Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: OTHER: Ketogenic diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Cost-efficiency Analysis of Primary Assessors for Patients With Knee Pain in Primary Care
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Physiotherapist as primary assessor|OTHER: Physician as primary assessor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms Underlying Spoken Language Production
Status: COMPLETED
Conditions: Aphasia, Anomic
Interventions: DEVICE: Real tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Effect of Rifampin on the Metabolism of Navitoclax
Status: COMPLETED
Conditions: Lymphoma, Including Chronic Lymphocytic Leukemia|Solid Tumors
Interventions: DRUG: navitoclax|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-intensity Exercise Training in Patients With Post-infarction Heart Failure
Status: COMPLETED
Conditions: Heart Failure|Myocardial Infarction
Interventions: BEHAVIORAL: Moderate intensity exercise training|BEHAVIORAL: High intensity exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Two Formulations of Telmisartan 80 mg Tablets in Healthy Adult Volunteers Under Fasting State
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Telmisartan|DRUG: Micardis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety, Tolerability and Pharmacokinetics of KUC 7483 CL Tablets in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: KUC 7483 CL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity of Co-administration of Measles and Japanese Encephalitis Vaccines
Status: COMPLETED
Conditions: Measles|Rubella|Japanese Encephalitis
Interventions: BIOLOGICAL: Measles-Rubella combined vaccine(MR)|BIOLOGICAL: Japanese Encephalitis alive vaccine(JE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) Plus COPEGUS (Ribavirin) With or Without Pioglitazone in Treatment-Naive Patients With Chronic Hepatitis C and Insulin Resistance.
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: peginterferon alfa-2a [Pegasys]|DRUG: ribavirin [Copegus]|DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Accuracy Study of the ActiSight Needle Guidance System in Patients Undergoing CT-Guided Percutaneous Chest Aspiration and Biopsy
Status: COMPLETED
Conditions: Biopsy
Interventions: DEVICE: sensor (ActiSight™ Needle Guidance System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bubble: A New VR-AI Way of Treatment for Hot Flashes in Women With Breast Cancer
Status: COMPLETED
Conditions: Hot Flashes|Breast Cancer
Interventions: DEVICE: Bubble: A New VR-AI Way of Treatment for Hot Flashes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of Mental Health Outcomes Following the 2020 Petrinja Earthquake
Status: UNKNOWN
Conditions: Mental Health Disorder|Post Traumatic Stress Disorder|Depression|Anxiety|Panic Disorder
Interventions: BEHAVIORAL: Family Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Bigger Cryoballoon on the Total Antral Lesion Size: Evaluation of POLARx FIT
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: POLARx FIT cryoballoon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dimethyl Fumarate in Adrenomyeloneuropathy
Status: RECRUITING
Conditions: Adrenomyeloneuropathy Without Cerebral Involvement
Interventions: OTHER: Placebo|DRUG: Dimethyl fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise Intervention for Patients With Cancer Cachexia: Effects of a 12-week Program and One-year Follow-up.
Status: ENROLLING_BY_INVITATION
Conditions: Cachexia-Anorexia Syndrome
Interventions: OTHER: Exercise Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Endostar Combined With Chemotherapy for Stage Ⅳ Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Soft Tissue Sarcoma, Adult, Stage IIB
Interventions: DRUG: Endostar|DRUG: Placebo|DRUG: AIM regimen / GT regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT