pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of PRP Versus BMC in Anterior Cruciate Ligament Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Reconstruction
Interventions: COMBINATION_PRODUCT: Platelet-Rich Plasma; Bone marrow concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarker-Linked Outcomes of Cellcept in Lupus Arthritis
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus|Arthritis
Interventions: DRUG: mycophenolate mofetil|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Aripiprazole in the Treatment of Risperidone-Induced Hyperprolactinemia
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DRUG: Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Efficacy, Safety, and Tolerability of JNJ-42165279 in Adolescent and Adult Participants With Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DRUG: JNJ-42165279|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Ridaforolimus in Patients With Advanced, Refractory or Recurrent Malignancies (MK-8669-001 AM5)(COMPLETED)
Status: COMPLETED
Conditions: Tumors|Lymphoma|Multiple Myeloma
Interventions: DRUG: ridaforolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pain Alleviating Strategies During Allergy Shots
Status: COMPLETED
Conditions: Immunotherapy|Allergy
Interventions: DEVICE: Buzzy Bee with Ice pack|DEVICE: Buzzy Bee without Ice pack|DEVICE: Shot Blocker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Oxaliplatin, Capecitabine and Bevacizumab as First Line Treatment for Patients With Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Oxaliplatin|DRUG: Bevacizumab|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plant-based Ingredient on Post Prandial Glucose in Type II Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DIETARY_SUPPLEMENT: Low dose plant based ingredient|DIETARY_SUPPLEMENT: High dose plant based ingredient|DIETARY_SUPPLEMENT: Reference food format
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of an Adaptive Computerized Training for Rehabilitation of Spatial Neglect in Stroke Survivors
Status: RECRUITING
Conditions: Stroke|Spatial Neglect|Neglect, Hemispatial|Attention Impaired|Cerebrovascular Disorders
Interventions: DEVICE: Adaptive computer game training|DEVICE: Standard computerized training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predicting Resting Energy Expenditure in Critically Ill Patients by Measuring Lean Body Mass by US
Status: COMPLETED
Conditions: Resting Energy Expenditure
Interventions: DIAGNOSTIC_TEST: US Muscle layer thickness (MLT) estimation|DIAGNOSTIC_TEST: REE estimation by indirect calorimetry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the DIABEO System in Poorly Controlled DM1 or DM2 Patients Treated With a Basal-bolus Insulin Regimen
Status: COMPLETED
Conditions: Diabetes
Interventions: DEVICE: DIABEO software
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Addition of Avastin (Bevacizumab) to Carboplatin and Paclitaxel Therapy in Patients With Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Paclitaxel|DRUG: Bevacizumab|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences
Status: RECRUITING
Conditions: Vasoconstriction|Vasodilation
Interventions: DRUG: Phenylephrine Hydrochloride|DRUG: Isoproterenol Hydrochloride|DRUG: Norepinephrine Bitartrate|DRUG: Propranolol Hydrochloride|DRUG: Phentolamine Mesylate|DRUG: Phenylephrine Hydrochloride|DRUG: Isoproterenol Hydrochloride|DRUG: Propranolol Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The STop UNhealthy Substance Use Now Trial
Status: RECRUITING
Conditions: Risky Health Behavior|Substance Use Disorders|Substance Abuse|Alcohol Use Disorder|Drinking, Alcohol|Substance Use
Interventions: OTHER: Practice Facilitation (PF)|OTHER: Learning Collaborative (LC)|OTHER: Performance Incentives (PI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: To Evaluate Safety and Efficacy of EC-18 in COVID-19 Infection to Pneumonia
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: EC-18|DRUG: Placebo EC-18
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Dilatation Tracheostomy, Broncoscopy, Pro-seal Laryngeal Mask
Status: COMPLETED
Conditions: Tracheostomy Complication
Interventions: PROCEDURE: Percutaneous Dilatation Tracheostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Phase 1b/2 Study of Carfilzomib, Carboplatin, and Etoposide in Patients With Previously Untreated Extensive Stage Small-cell Lung Cancer
Status: COMPLETED
Conditions: Extensive-Stage Small-Cell Lung Cancer
Interventions: DRUG: Carfilzomib|DRUG: Carboplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Entinostat and Anastrozole in Treating Postmenopausal Women With TNBC That Can Be Removed by Surgery
Status: TERMINATED
Conditions: Estrogen Receptor-negative Breast Cancer|HER2-negative Breast Cancer|Progesterone Receptor-negative Breast Cancer|Stage I Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Triple-negative Breast Cancer
Interventions: DRUG: entinostat|DRUG: anastrozole|OTHER: diagnostic laboratory biomarker analysis|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Dietary Fiber Supplementation (Soloways) in Patients With Specific Genetic Polymorphisms
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: glucomannan, inulin, and psyllium|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: GM-CSF, Fosfomycin and Metronidazole for Pouchitis in Ulcerative Colitis Patients After Restorative IPAA Surgery
Status: RECRUITING
Conditions: Pouchitis
Interventions: DRUG: GM-CSF, fosfomycin and metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self Management and Reminders With Technology: SMART Appraisal of an Integrated Personal Health Record (PHR)
Status: COMPLETED
Conditions: Cardiovascular Risk
Interventions: OTHER: SMART PHR|OTHER: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy of Iodine-131 Anti-B1 Antibody for Intermediate Grade Non-Hodgkin's Lymphoma Following First Line CHOP
Status: UNKNOWN
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Iodine-131 Anti-B1 Antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Physical Therapy in Improving the Health of Patients With Diabetic Peripheral Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathies|Peripheral Nervous System Diseases
Interventions: OTHER: Strength & Balance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study in Healthy Men to Test the Influence of BI 1358894 on the Amount of the Medicines Rosuvastatin and Dabigatran in the Blood
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rosuvastatin|DRUG: BI 1358894|DEVICE: Dabigatran etexilate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of ORMD-0801 (Oral Insulin) in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: T2DM (Type 2 Diabetes Mellitus)
Interventions: DRUG: Cohort A: ORMD-0801|DRUG: Placebo oral capsule|DRUG: Cohort B: ORMD-0801
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Weighted Blanket to Treat Anxiety Related to Trying New Foods the Pediatric Population
Status: RECRUITING
Conditions: Food Neophobia|Picky Eating|Avoidant Restrictive Food Intake Disorder|Anxiety State
Interventions: DEVICE: weighted blanket
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Optimization of Therapeutic Drug Monitoring of Vancomycin in Pediatric Patients With an Implanted Port Catheter
Status: TERMINATED
Conditions: Catheter Related Blood Stream Infections
Interventions: PROCEDURE: Extensive flushing of the port catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Tracheal Positive Pressure During High Flow Nasal Oxygen Administration in Critically Ill Patients: a Physiologic Study.
Status: NOT_YET_RECRUITING
Conditions: Acute Respiratory Failure|High Flow Nasal Cannula|Critically Ill|Airway Disease|Positive End Expiratory Pressure|Diaphragm Disease
Interventions: DEVICE: HIGH FLOW NASAL OXYGEN
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Could Ephedrine Replace Dexmedetomidine Fordexmedetomidine Prevention of Shivering in Women Undergoing Cesarean Section Under Spinal Anaesthesia
Status: RECRUITING
Conditions: Prevention of Shivering With Spinal Anaesthesia
Interventions: DRUG: Ephedrine|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Safety and Feasibility Study of Umbilical Cord Blood Mononuclear Cells Transplant to Treat Ischemic Stroke
Status: UNKNOWN
Conditions: Stroke|Ischemic Stroke|Brain Ischemia
Interventions: BIOLOGICAL: UCBMC|PROCEDURE: surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide and Rituximab in the Treatment of Relapsed Mantle Cell Lymphoma (MCL) and Diffuse Large B-Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Lenalidomide|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of Acupuncture and Nonsteroidal Anti-inflammatory Drugs for the Management of Aromatase Inhibitor Induced Arthralgia Among Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Diclofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Deciphering the Role of Incretin Hormones in Weight Loss-induced Remission of Type 2 Diabetes (DIABeat)
Status: NOT_YET_RECRUITING
Conditions: Obesity|Diabetes Mellitus Type 2 in Obese
Interventions: BEHAVIORAL: Weight loss-induced Diabetes Remission
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Manual Lymphatic Drainage and Therapeutic Ultrasound on Breast Engorgement
Status: COMPLETED
Conditions: Postpartum Complication
Interventions: OTHER: MANUAL LYMPHATIC DRAINAGE|OTHER: THERAPEUTIC ULTRASOUND
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Coronary Sinus Occlusion on Myocardial Ischemia (Pilot Study)
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Sinus|Circulation, Collateral|Ischemia|Collateral Flow Index
Interventions: PROCEDURE: intermittent coronary sinus occlusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell ( CAR-T) Therapy in Subjects With Non-relapsing and Progressive Forms of Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis|Multiple Sclerosis, Primary Progressive|Multiple Sclerosis, Secondary Progressive
Interventions: BIOLOGICAL: KYV-101 anti-CD19 CAR-T cell therapy|DRUG: Standard lymphodepletion regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Fluoxetine and/or DHEA
Status: RECRUITING
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Placebo Oral Tablet|DRUG: Placebo Oral Tablet|DRUG: Fluoxetine|DRUG: DHEA|DRUG: Fluoxetine and DHEA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Stereotactic Body Radiation Therapy, Tremelimumab and Durvalumab in Treating Participants With Recurrent or Metastatic Cervical, Vaginal, or Vulvar Cancers
Status: COMPLETED
Conditions: Advanced Cervical Adenocarcinoma|Advanced Vaginal Carcinoma|Advanced Vulvar Carcinoma|Human Papillomavirus-Related Cervical Squamous Cell Carcinoma|Human Papillomavirus-Related Vulvar Squamous Cell Carcinoma|Metastatic Cervical Adenocarcinoma|Metastatic Cervical Carcinoma|Metastatic Cervical Squamous Cell Carcinoma, Not Otherwise Specified|Metastatic Vaginal Adenocarcinoma|Metastatic Vaginal Carcinoma|Metastatic Vulvar Carcinoma|Recurrent Cervical Adenocarcinoma|Recurrent Cervical Carcinoma|Recurrent Cervical Squamous Cell Carcinoma, Not Otherwise Specified|Recurrent Vaginal Carcinoma|Recurrent Vulvar Carcinoma|Stage III Cervical Cancer AJCC v8|Stage III Vaginal Cancer AJCC v8|Stage III Vulvar Cancer AJCC v8|Stage IIIA Cervical Cancer AJCC v8|Stage IIIA Vulvar Cancer AJCC v8|Stage IIIB Cervical Cancer AJCC v8|Stage IIIB Vulvar Cancer AJCC v8|Stage IIIC Vulvar Cancer AJCC v8|Stage IV Cervical Cancer AJCC v8|Stage IV Vaginal Cancer AJCC v8|Stage IV Vulvar Cancer AJCC v8|Stage IVA Cervical Cancer AJCC v8|Stage IVA Vaginal Cancer AJCC v8|Stage IVA Vulvar Cancer AJCC v8|Stage IVB Cervical Cancer AJCC v8|Stage IVB Vaginal Cancer AJCC v8|Stage IVB Vulvar Cancer AJCC v8|Vaginal Squamous Cell Carcinoma, Not Otherwise Specified|Vulvar Adenocarcinoma|Vulvar Squamous Cell Carcinoma
Interventions: BIOLOGICAL: Durvalumab|OTHER: Laboratory Biomarker Analysis|RADIATION: Stereotactic Radiosurgery|BIOLOGICAL: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tailored Health Self-Management Interventions for Highly Distressed Family Caregivers
Status: COMPLETED
Conditions: Distress|Caregiver
Interventions: BEHAVIORAL: Resourcefulness Training|BEHAVIORAL: Biofeedback training|BEHAVIORAL: Bipolar Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: STRADIVARIUS (Strategy To Reduce Atherosclerosis Development InVolving Administration of Rimonabant - the Intravascular Ultrasound Study)
Status: COMPLETED
Conditions: Coronary Atherosclerosis
Interventions: DRUG: Rimonabant (SR141716)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of Oxygen Therapy and Clinical Feasibility of High Flow Nasal Cannula During Moderate and Deep Sedation in Pediatric Patients
Status: RECRUITING
Conditions: Pediatric Sedation
Interventions: DEVICE: high flow nasal cannula|DEVICE: nasal prong
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Azithromycin 600 Mg Tablets, Fed
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Azithromycin 600 mg Tablet|DRUG: Zithromax® 600 mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Surufatinib Combined With Serplulimab in the Treatment of Advanced Solid Tumors With Neuroendocrine Differentiation That Failed Standard Therapy
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumors With Neuroendocrine Differentiation
Interventions: DRUG: surufatinib、serplulimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetics of Familial and Sporadic ALS
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis (ALS)|Familial Amyotrophic Lateral Sclerosis|ALS With Frontotemporal Dementia (ALS/FTD)|Lou Gehrig's Disease|Motor Neuron Disease (MND)|Primary Lateral Sclerosis (PLS)|Sporadic ALS (SALS)
Interventions: OTHER: Genetic study of ALS families
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Sacituzumab Govitecan (IMMU-132) in Platinum-resistant Ovarian Cancer Patients
Status: RECRUITING
Conditions: Ovarian Carcinoma
Interventions: DRUG: Sacituzumab govitecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Decitabine in Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Cytarabine or Supportive Care|DRUG: Dacogen (decitabine) only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insulin Resistance in Adolescents
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: OTHER: Oral Glucose Tolerance Test (OGTT)|DEVICE: 3 Tesla MRI|DEVICE: Intravenous Catheter|OTHER: Cognitive Tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Stimulating Amyloid Clearance in Cerebral Amyloid Angiopathy
Status: NOT_YET_RECRUITING
Conditions: Cerebral Amyloid Angiopathy
Interventions: DRUG: XYWAV|DEVICE: gammaCore Sapphire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chloroquine, Hydroxychloroquine or Only Supportive Care in Patients AdmItted With Moderate to Severe COVID-19
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Chloroquine Sulfate|DRUG: Hydroxychloroquine|OTHER: Standard supportive care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cytokine Microdialysis for Real-Time Immune Monitoring in Glioblastoma Patients Undergoing Checkpoint Blockade
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: Nivolumab|DRUG: BMS-986016
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET-MRI in Chronic Traumatic Brain Injury (CTBI)
Status: ENROLLING_BY_INVITATION
Conditions: Chronic Traumatic Brain Injury
Interventions: OTHER: Anti-inflammatory Diet|DIETARY_SUPPLEMENT: N-acetyl Cysteine|BEHAVIORAL: Neuro Emotive Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A RCT on the Effect of Endometrial Injury on Improving Ongoing Pregnancy Rate in Subfertile Women Undergoing FET Cycles
Status: TERMINATED
Conditions: Subfertility
Interventions: PROCEDURE: Endometrial biopsy|PROCEDURE: control procedure|DEVICE: Pipelle catheter (Pipelle de Cornier, Laboratoire C.C.D., France)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oritavancin Versus IV Vancomycin for the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infection
Status: COMPLETED
Conditions: Wound Infection|Abscess|Systemic Inflammation|Cellulitis
Interventions: DRUG: Single-Dose IV Oritavancin Diphosphate|DRUG: IV Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SUPPLEMENTARY EFFECTS OF RESISTANCE TRAINING IN ADDITION TO JOINT MOBILIZATION IN PERSONS WITH KNEE OSTEOARTHRITIS
Status: ENROLLING_BY_INVITATION
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Joint Mobilization|PROCEDURE: Resistance Exercise Training|DEVICE: Transcutaneous Electric Nerve Stimulation (TENS)|DEVICE: Heating Pad
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Fat and High-Density Lipoprotein (HDL) Metabolism-Effect of Carbohydrate and Fat Intake
Status: COMPLETED
Conditions: Overweight|Cardiovascular Diseases
Interventions: BEHAVIORAL: Low Fat and High Carbohydrate Diet|BEHAVIORAL: High Fat and Low Carbohydrate Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cefpodoxime vs Ciprofloxacin for Acute Cystitis
Status: COMPLETED
Conditions: Urinary Tract Infection
Interventions: DRUG: Cefpodoxime|DRUG: Ciprofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Orthopilot Elite Post-Market Clinical Follow-Up
Status: COMPLETED
Conditions: Degenerative Osteoarthritis|Rheumatoid Arthritis|Posttraumatic Arthropathy|Instability, Joint|Stiffness of Knee, Not Elsewhere Classified|Deformity of Knee
Interventions: DEVICE: Computer assisted primary total knee replacement with OrthoPilot FS101 navigation system and Software 5.1|DEVICE: Computer assisted primary total knee replacement with OrthoPilot Elite navigation system and Software 6.0
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Closure of the Uterine Artery at Its Origin vs at the Cervix: a Randomized Trial
Status: COMPLETED
Conditions: Anatomy|Laparoscopy|Uterine Artery|Hysterectomy
Interventions: PROCEDURE: uterine artery closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: HFS-guided Renal Ablation for Improving Outcome of Renal Denervation Procedure
Status: UNKNOWN
Conditions: Hypertension
Interventions: DEVICE: Renal denervation guided by HFS|DEVICE: Renal denervation as standard procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pacifier Activated Device and Mother's Voice in Infants at High-risk for Cerebral Palsy
Status: COMPLETED
Conditions: Infant Development|Infant,Premature|Hydrocephalus|Neonatal Encephalopathy|Infarction|PVL|Thrombosis|Intraventricular Hemorrhage
Interventions: DEVICE: pacifier-activated device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity of Alternative Annual Influenza Vaccination Strategies in Older Adults in Hong Kong
Status: ACTIVE_NOT_RECRUITING
Conditions: Influenza, Human
Interventions: BIOLOGICAL: Standard inactivated influenza vaccine (NH formulation)|BIOLOGICAL: MF 59 adjuvanted inactivated influenza vaccine (NH formulation)|BIOLOGICAL: High-dose inactivated influenza vaccine (NH formulation)|BIOLOGICAL: Recombinant hemagglutinin inactivated influenza vaccine (NH formulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nasal High-frequency Oscillatory Ventilation (NHFOV) for Ventilated Newborn Infants With BPD
Status: RECRUITING
Conditions: Bronchopulmonary Dysplasia|Nasal High-frequency Oscillatory Ventilation|Nasal Continuous Positive Airway Pressure|Neonate
Interventions: DEVICE: NHFOV|DEVICE: NCPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Doxorubicin Hydrochloride Liposome, Melphalan, and Bortezomib in Treating Patients With Relapsed or Refractory Stage I, Stage II, or Stage III Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: bortezomib|DRUG: melphalan|DRUG: pegylated liposomal doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Cryopreserved-thawed Embryo Transfer With or Without Gonadotropin Releasing Hormone Agonist
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: Embryo transfer|PROCEDURE: Serum Estradiol and Progesterone levels|DRUG: GnRH agonist|DRUG: External Estradiol|DRUG: Progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2b Study of MBS2320 in Participants With Methotrexate-Refractory RA
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: MBS2320 5 mg|DRUG: MBS2320 20 mg|DRUG: MBS2320 40 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: UARK 2008-02 A Trial for High-risk Myeloma Evaluating Accelerating and Sustaining Complete Remission
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Velcade|DRUG: Melphalan|DRUG: Thalidomide|DRUG: Dexamethasone|DRUG: Cisplatin|DRUG: Adriamycin|DRUG: Cyclophosphamide|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kaffes Stent in the Management of Post-surgical Biliary Strictures
Status: UNKNOWN
Conditions: Benign Biliary Stricture|Biliary Stricture|Cholangitis|Bile Duct Stricture|Bile Duct Injury
Interventions: DEVICE: Metallic stent|DEVICE: Multiple plastic stents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effect of an Herbal Medicine on Anxiety
Status: UNKNOWN
Conditions: Anxiety Disorders
Interventions: DRUG: Passiflora|DRUG: Valeriana officinalis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluations of the Effects of Tranexamic Acid and Chlorhexidine Gel on Alveolar Osteitis Incidence
Status: ACTIVE_NOT_RECRUITING
Conditions: Alveolar Osteitis
Interventions: DRUG: Absorbable Gelatin|DRUG: Chlorhexidine|DRUG: Tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Endoscopic Characterisation of Inflammation in EoE
Status: UNKNOWN
Conditions: Eosinophilic Esophagitis
Interventions: DEVICE: EG-760Z endoscope by Fujifilm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Stabilization Exercises Alone vs Stabilization Exercises Plus Neuromuscular Electrical Stimulation in People With Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Rehabilitation exercises|DEVICE: Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: High Dose Dual Therapy vs Clarithromycin Triple Therapy for Treatment Naive H Pylori Infection in an Urban Population
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Amoxicillin|DRUG: Omeprazole|DRUG: Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regorafenib After Progression on Atezolizumab Plus Bevacizumab in Advanced HCC
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study to Evaluate Toripalimab (JS001) in Patients With Advanced GC, ESCC, NPC, HNSCC
Status: UNKNOWN
Conditions: Gastric Adenocarcinoma|Esophageal Squamous Cell Carcinoma|Nasopharyngeal Carcinoma|Head and Neck Squamous Cell Carcinoma
Interventions: BIOLOGICAL: 3 mg/kg anti-PD-1 mAb JS001 Q2W|BIOLOGICAL: 360 mg anti-PD-1 mAb JS001 Q3W|BIOLOGICAL: 240mg anti-PD-1 mAb JS001 Q3W
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of I-Gel Laryngeal Mask Airway Placement Methods in Elective Surgery
Status: COMPLETED
Conditions: Effective I -Gel Mask Airway Placement Technique
Interventions: OTHER: i-gel placement maneuvers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Long Acting Insulin Versus Multiple Dose Regimen for Control of Gestational Diabetes Mellitus
Status: COMPLETED
Conditions: Long Acting Insulin in Control of Gestational Diabetes Mellitus
Interventions: DRUG: Long acting insulin|DRUG: multiple dose regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diurnal Variations of Brain Metabolite Concentrations in 1H-MRS
Status: COMPLETED
Conditions: Diurnal Variations of Cerebral Metabolite
Interventions: OTHER: magnetic resonance spectroscopy (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Internal Iliac Artery Ligation and Abnormally Invasive Placenta
Status: COMPLETED
Conditions: Placenta Percreta
Interventions: PROCEDURE: internal iliac artery ligation|PROCEDURE: Cesarean Hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate Broadlumab vs Placebo and Ustekinumab
Status: TERMINATED
Conditions: Psoriasis
Interventions: BIOLOGICAL: 210mg Brodalumab|BIOLOGICAL: 140mg Brodalumab|BIOLOGICAL: Ustekinumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Combination of Enteric-coated Mycophenolate Sodium (EC-MPS), Basiliximab, and C2-monitored Cyclosporine in de Novo Renal Transplant Recipients at Potential High Risk of Delayed Graft Function (DGF)
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: Enteric-Coated Mycophenolate Sodium (EC-MPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Continuous Oral Contraceptives and Doxycycline
Status: COMPLETED
Conditions: Contraceptives, Oral
Interventions: DRUG: Lybrel|DRUG: Doxycycline|DRUG: Oracea|DRUG: Placebo|DRUG: Doxycycline 100bid x5 days at the time of bleeding|DRUG: Subantimicrobial doxycycline daily|DRUG: placebo daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Predictive Models of Hepatic Decompensation and Survival Outcomes in Pediatric Patients With Cirrhosis
Status: RECRUITING
Conditions: Cirrhosis|Biliary Atresia|Choledochal Cyst|Primary Sclerosing Cholangitis|HBV|HCV|Autoimmune Hepatitis
Interventions: OTHER: Prediction model
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate Serum Testosterone Levels in Patients With Metastatic Castration-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Zytiga® (Abiraterone Acetate)|DRUG: SoluMatrix™ (Abiraterone Acetate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Palliative Care on Quality of Life and Symptom Control in Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Lung Cancer
Interventions: OTHER: educational intervention|OTHER: medical chart review|OTHER: questionnaire administration|PROCEDURE: end-of-life treatment/management|PROCEDURE: psychosocial assessment and care|PROCEDURE: quality-of-life assessment|PROCEDURE: management of therapy complications|PROCEDURE: assessment of therapy complications
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [Pf-01913539] In Subjects With Hepatic Impairment And Normal Hepatic Function
Status: COMPLETED
Conditions: Hepatic Failure
Interventions: DRUG: Dimebon|DRUG: Dimebon|DRUG: Dimebon|DRUG: Dimebon
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simultaneous Integrated Boost for Mediastinal Lymph Node Recurrence After Radical Surgery of Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Cancer|Salvage Radiotherapy|Dose-escalation|Mediastinal Lymph Node Recurrence
Interventions: RADIATION: treatment group(phase I)|RADIATION: treatment group (phase II)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiometabolic Health Intervention Using Movement-to-Music Exercise
Status: RECRUITING
Conditions: Cardiometabolic Risk Factors in Adult Wheelchair Users
Interventions: OTHER: Instructor-led, one-on-one M2M exercise group|OTHER: Self-guided control with pre-recorded standard exercise videos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-center, Randomized, Double-blind, Double-dummy Clinical Study to Evaluate the Safety and Efficacy of Prulifloxacin Film-coated Tablet for the Treatment of Acute Uncomplicated Lower Urinary Tract Infection With Levofloxacin Hydrochloride Tablet as Active Control
Status: COMPLETED
Conditions: Acute Lower Urinary Tract Infection
Interventions: DRUG: prulifloxacin|DRUG: Levofloxacin|DRUG: Prulifloxacin Placebo|DRUG: Levofloxacin Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Efficacy of Calprotectin and Cross-linked N-telopeptides
Status: UNKNOWN
Conditions: Peri-Implantitis|Dental Implant Failed
Interventions: DIAGNOSTIC_TEST: Collection of sulcular (crevicular) fluid|DIAGNOSTIC_TEST: Probing depth|DIAGNOSTIC_TEST: Bleeding on probing|DIAGNOSTIC_TEST: Gingival index|DIAGNOSTIC_TEST: Bone loss rate of alveolar bone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Efficacy of Micro-Pulse Steroid Therapy as Induction Therapy in Patients With Polymyalgia Rheumatica
Status: UNKNOWN
Conditions: Polymyalgia Rheumatica
Interventions: DRUG: Betamethasone|DRUG: isotonic sodium chloride solution (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Infrared-LED During Physical Training for Rehabilitation, Physical Performance and Body Aesthetics
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Photon stimulation by light-emitting diodes (LEDs)|OTHER: Treadmill training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Preliminary Investigation of Pre-Frontal Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder
Status: COMPLETED
Conditions: Cannabis Use Disorder
Interventions: DEVICE: Active rTMS|DEVICE: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: STOP-COVID19: Superiority Trial Of Protease Inhibition in COVID-19
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Brensocatib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Synbiotics in Advanced HIV Infection
Status: COMPLETED
Conditions: HIV Infection Asymptomatic
Interventions: DIETARY_SUPPLEMENT: PMT25341|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nasopharyngeal Wash With Normal Saline on SARS-CoV2 Viral Load
Status: COMPLETED
Conditions: SARS-CoV2 Infection
Interventions: OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study for Secondary Hyperparathyroidism in Chronic Renal Insufficiency Patients
Status: COMPLETED
Conditions: Secondary Hyperparathyroidism|Chronic Renal Insufficiency
Interventions: DRUG: cinacalcet (AMG 073)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Of The Safety, Tolerability And Effective Of Voriconazole For The Treatment Of Serious Candida Infection And Candida Infection Of The Throat In Pediatric Patients
Status: TERMINATED
Conditions: Candidiasis
Interventions: DRUG: voriconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Structural Health Monitoring to Improve Diagnosis and Treatment of Low Back Injury in U.S. Service Members- Phase 2
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Dry Needling|OTHER: Sham Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Caldolor for Treatment of Pain in Post-Operative Adult Patients
Status: COMPLETED
Conditions: Pain
Interventions: OTHER: Normal saline as placebo comparator|DRUG: Intravenous ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Polymeric Microspheres vs Sculptra® in the Treatment of Moderate to Severe Nasolabial Folds
Status: ACTIVE_NOT_RECRUITING
Conditions: Nasolabial Fold Wrinkles
Interventions: DEVICE: PBF PLLA microsphere (injectable poly-L-lactic acid)|DEVICE: Sculptra®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Increasing Dose Study of Pramipexole in Two-way Cross-over Comparison of ER Tablet Versus IR Tablet in Japanese Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pramipexole ER tablet|DRUG: Pramipexole IR tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Cardiac Monitoring in Epilepsy
Status: TERMINATED
Conditions: Focal Epilepsy|Intractable Epilepsy|Epileptic Encephalopathy|Lennox Gastaut Syndrome|Symptomatic Epilepsy|Generalized Epilepsy
Interventions: DEVICE: Reveal LINQ ICM System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiation Therapy (SBRT) in Newly Diagnosed Advanced Staged Lung Adenocarcinoma (Sindas)
Status: TERMINATED
Conditions: Stage IV EGFR Mutated Non-Small Cell Lung Cancer
Interventions: RADIATION: Radiation: SBRT|DRUG: TKI (Gefitinib or Tarceva )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Magnesium Sulfate on Postoperative Pain
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Magnesium Sulfate|DRUG: normal saline isotonic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Incidence of Cerebral Lesions Post Pulmonary Vein Ablation Catheter (PVAC)
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: OTHER: Magnetic Resonance Imaging (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Extended Release Extended-release (ER) OROS Paliperidone Tolerability, as Compared to Immediate-release (IR)Risperidone, in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: extended-release (ER) OROS paliperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Computerized Cognitive Rehabilitation of Executive Deficits in Stroke Patients
Status: RECRUITING
Conditions: Stroke|Executive Dysfunction
Interventions: DEVICE: Computerized Gaming Rehabilitation Program 1|DEVICE: Computerized Gaming Rehabilitation Program 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VR/AR Educational Module on Oral Care Practices for Home Care Worker
Status: COMPLETED
Conditions: Virtual Reality|Augmented Reality|Oral Care Performance
Interventions: BEHAVIORAL: VR and AR oral healthcare curriculum training|BEHAVIORAL: traditional teaching methods oral healthcare curriculum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Intravenous Ketorolac for Postoperative Pain in Laparoscopic Donor Nephrectomy
Status: COMPLETED
Conditions: Nephrectomy|Laparoscopic Donor Nephrectomy
Interventions: DRUG: Ketorolac|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Heparin Free Haemodialysis With Haemodialyzers "VIE" Versus "EVODIAL"
Status: COMPLETED
Conditions: Adult Chronic Haemodialysis Patients Since at Least 3 Months
Interventions: OTHER: heparin free haemodialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study in Adolescents and Adults With Eosinophilic Esophagitis (EoE) Measuring Histologic Response and Determine if Reduction in Dysphagia is Achieved
Status: COMPLETED
Conditions: Eosinophilic Esophagitis (EoE)
Interventions: DRUG: Oral Budesonide Suspension (OBS)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Heparin-Induced Thrombocytopenia Score Card Study
Status: COMPLETED
Conditions: Heparin-Induced Thrombocytopenia
Interventions: DEVICE: ID-PaGIA Heparin/PF4 antibody test|PROCEDURE: Clinical Prediction Score-HIT Score Card
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC