pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Selumetinib and Akt Inhibitor MK-2206 in Treating Patients With Refractory or Advanced Gallbladder or Bile Duct Cancer That Cannot Be Removed By Surgery
Status: WITHDRAWN
Conditions: Adenocarcinoma of the Gallbladder|Adenocarcinoma With Squamous Metaplasia of the Gallbladder|Adult Primary Cholangiocellular Carcinoma|Advanced Adult Primary Liver Cancer|Cholangiocarcinoma of the Extrahepatic Bile Duct|Localized Unresectable Adult Primary Liver Cancer|Metastatic Extrahepatic Bile Duct Cancer|Recurrent Adult Primary Liver Cancer|Recurrent Extrahepatic Bile Duct Cancer|Stage II Gallbladder Cancer|Stage IIIA Gallbladder Cancer|Stage IIIB Gallbladder Cancer|Stage IVA Gallbladder Cancer|Stage IVB Gallbladder Cancer|Unresectable Extrahepatic Bile Duct Cancer
Interventions: DRUG: selumetinib|DRUG: Akt inhibitor MK2206|OTHER: laboratory biomarker analysis|OTHER: pharmacogenomic studies|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Mixture of Allium Extracts on LDL Cholesterol Levels Volunteers With Elevated LDL Cholesterol Levels
Status: COMPLETED
Conditions: Cardiovascular Health
Interventions: DIETARY_SUPPLEMENT: Garlic and onion concentrate|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ultrase® MT20 in Improving the Coefficient of Fat Absorption (CFA) in Children With Cystic Fibrosis (CF) and Pancreatic Insufficiency (PI)
Status: COMPLETED
Conditions: Cystic Fibrosis|Pancreatic Insufficiency
Interventions: DRUG: Ultrase® MT20
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Pharmacology Study of JNS010 (Paliperidone Palmitate) in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Paliperidone palmitate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nelipepimut-S Plus GM-CSF Vaccine Therapy in Treating Patients With Breast Cancer
Status: COMPLETED
Conditions: Breast Ductal Carcinoma In Situ
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Nelipepimut-S Plus GM-CSF Vaccine|BIOLOGICAL: Sargramostim|PROCEDURE: Surgical Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Cord Blood Infusion for Children With Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autism Spectrum Disorder|ASD|Autism|PDD
Interventions: BIOLOGICAL: Cord Blood Infusion|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IVIG-eye Drops Treatment for Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Intravenous Immune Globulin (IVIG)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Observational Study on the Risk in Developing Long-COVID Syndrome and in Contracting SARS-CoV-2 Infection After COVID-19 Vaccination in Relation to Vitamin D3 Supplementation
Status: ACTIVE_NOT_RECRUITING
Conditions: Vitamin d Deficiency|COVID-19|Long COVID
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Decompression and Drainage Seton for Treatment of High Horseshoe Anal Fistula
Status: RECRUITING
Conditions: Anal Fistula
Interventions: PROCEDURE: Decompression and drainage seton|PROCEDURE: Cutting seton
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Local Administration of DepoTXA for Reduced Postsurgical Bleeding in Subjects Undergoing TKA
Status: TERMINATED
Conditions: Total Knee Arthroplasty
Interventions: DRUG: DepoTXA|DRUG: Tranexamic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Electro-acupuncture for the Prevention of Taxane Induced Myalgias and Neuropathy
Status: COMPLETED
Conditions: Breast Cancer|Neuropathy
Interventions: DEVICE: Electro-acupuncture|DEVICE: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Gene Edited Autologous Neoantigen Targeted TCR T Cells With or Without Anti-PD-1 in Patients With Solid Tumors
Status: SUSPENDED
Conditions: Solid Tumor
Interventions: BIOLOGICAL: NeoTCR-P1 adoptive cell therapy|BIOLOGICAL: nivolumab|BIOLOGICAL: IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evidence-Based Colorectal Cancer Screening for the Uninsured
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: OTHER: FIT Invitation Only|OTHER: FIT plus $5 Incentive|OTHER: FIT plus $10 Incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: LUX-Head&Neck 1: A Phase III Trial of Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic (R/M) Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy
Status: COMPLETED
Conditions: Head and Neck Neoplasms|Carcinoma, Squamous Cell
Interventions: DRUG: Afatinib|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prediction and Evaluation by ETCOc of Neonatal Hyperbilirubinemia Cohort
Status: RECRUITING
Conditions: Neonatal Jaundice|Neonatal Hyperbilirubinemia|Hemolysis Neonatal
Interventions: DIAGNOSTIC_TEST: End-tidal carbon monoxide-corrected (ETCOc)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Evaluating 13-Valent Pneumococcal Conjugate Vaccine in Healthy Infants in Mexico
Status: COMPLETED
Conditions: Vaccines, Pneumococcal
Interventions: BIOLOGICAL: 13-valent pneumococcal conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Multicenter Study for Diagnosis and Treatment of Perianal Abscesses
Status: RECRUITING
Conditions: Perianal Abscess|Anal Fistulas|Incontinence
Interventions: PROCEDURE: Perianal abscess drainage|DEVICE: 3D ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT Study on Safety of LPD and OPD in the Treatment of Periampullary Tumors
Status: UNKNOWN
Conditions: Periampullary Tumor|Complication|Death|Survival
Interventions: PROCEDURE: laparoscopic pancreaticoduodenectomy|PROCEDURE: Open pancreaticoduodenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-Based Therapy for Interstitial Cystitis/Bladder Pain Syndrome
Status: COMPLETED
Conditions: Interstitial Cystitis|Mindfulness|Complementary Medicine|Painful Bladder Syndrome
Interventions: OTHER: Mindfulness-based Stress Reduction (MBSR)|OTHER: Usual medical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Muscle Stem Cell Therapy for Treatment of Congenital Urinary Incontinence in Epispadias Patients
Status: NOT_YET_RECRUITING
Conditions: Urinary Incontinence|Epispadias, Male
Interventions: BIOLOGICAL: Primary human muscle stem cells (Satori-01)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Microfragmented Adipose Tissue Compared to Saline Injection for the Treatment of Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis|Osteo Arthritis Knee
Interventions: DEVICE: Microfragmented Adipose Tissue derived using the Lipogems® System|DRUG: Saline Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of ITF2357 in AIS
Status: UNKNOWN
Conditions: Autoinflammatory Syndromes|HIDS|TRAPS|Schnitzler's Syndrome
Interventions: DRUG: ITF2357
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Estimate the Time Course of PF-00241939 Concentration in the Blood Following Dosing by Oral Inhalation From Dry Powder Inhalers
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Treatment A|DRUG: Treatment B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Shaping Motor Neural Functioning of Developmental Stuttering to Improve Fluency
Status: RECRUITING
Conditions: Stuttering
Interventions: DEVICE: transcranial Electrical Stimulation|BEHAVIORAL: Speech Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessing Lung Inhomogeneity During Ventilation for Acute Hypoxemic Respiratory Failure
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome|Mechanical Ventilation Pressure High|Hypoxemic Respiratory Failure
Interventions: DEVICE: Electrical Impedance Tomography|OTHER: ExPRESS-derived PEEP level
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of NAVA (Neurally Adjusted Ventilatory Assist) on Ventilatory Demand During Pediatric Non-Invasive Ventilation
Status: COMPLETED
Conditions: Respiratory Failure
Interventions: DEVICE: Neurovent Monitor XIII|DEVICE: Neurovent Monitor XIII|DEVICE: Neurovent Monitor XIII|DEVICE: Neurovent Monitor XIII|DEVICE: Neurovent Monitor XIII
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Holmium Radioembolization as Adjuvant Treatment to RFA for Early Stage HCC: Dose Finding Study
Status: COMPLETED
Conditions: HCC|Early Stage HCC
Interventions: DEVICE: Quirem Medical Holmium-166 radioembolization microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictive Factors and Autonomy Level Change
Status: RECRUITING
Conditions: Memory Impairment
Interventions: OTHER: The Lawton Instrumental Activities of Daily Living score (IADL), and the disability assessment of dementia score (DAD-6
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Validation of a New Standardized Clinical Anemia Evaluation Score Using a Hb Visual Scale in Nephrological Patients
Status: COMPLETED
Conditions: Anemia
Interventions: PROCEDURE: Estimation of Hb concentrations with the HemoHue card
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Pain Management Techniques Following Anterior Cruciate Ligament Repair Surgery
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Reconstruction
Interventions: PROCEDURE: Hamstrings block|PROCEDURE: Obturator block|PROCEDURE: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Effectiveness of Asoprisnil and Estrogen Administration to Postmenopausal Women
Status: COMPLETED
Conditions: Amenorrhea|Postmenopause
Interventions: DRUG: Asoprisnil/Premarin|DRUG: Asoprisnil/Premarin|DRUG: Asoprisnil/Premarin|DRUG: Placebo and Premarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retraining Neural Pathways Improves Cognitive Skills After A Mild Traumatic Brain Injury
Status: RECRUITING
Conditions: MTBI - Mild Traumatic Brain Injury
Interventions: BEHAVIORAL: PATH neurotraining|BEHAVIORAL: Orientation Discrimination|BEHAVIORAL: N-Back Working Memory Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Tesetaxel on the QTc Interval and the Effect of Food, Itraconazole, and Rifampin on Tesetaxel Pharmacokinetics in Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: DRUG: Tesetaxel|DRUG: Tesetaxel|DRUG: Itraconazole|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrative Analysis of Tumor Microenvironment and Optimization of Immunotherapy Duration in NSCL Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: ICI treatment discontinuation|DRUG: ICI treatment continuation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Breathing and Attention Training (BAT) on Pain Modulation
Status: RECRUITING
Conditions: Fibromyalgia
Interventions: BEHAVIORAL: Breathing and Attention Training (BAT)|BEHAVIORAL: Breathing Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot Study
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: Angiotensin II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiolabeled Gallium-68 (68Ga-PSMA) for PET/CT Imaging to Detect Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: 68Ga-PSMA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intravesical Injection of Dextrose to Improve Lower Urinary Tract Symptoms Caused by Chronic Cystitis
Status: COMPLETED
Conditions: Bladder Pain Syndrome|Interstitial Cystitis
Interventions: DRUG: Dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Sodium Shale Oil Sulponate 1% Shampoo in the Treatment of Pityriasis Capitis
Status: COMPLETED
Conditions: Dandruff
Interventions: OTHER: Shampoo (inactive)|OTHER: Sodium shale oil sulponate 1% shampoo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating AB248 Alone or in Combination With Pembrolizumab in Adult Patients With Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor|Non Small Cell Lung Cancer|Melanoma|Squamous Cell Carcinoma of Head and Neck|Renal Cell Carcinoma
Interventions: BIOLOGICAL: AB248|BIOLOGICAL: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Far Infrared Radiation for Sickle Cell Pain Management
Status: UNKNOWN
Conditions: Anemia, Sickle Cell
Interventions: RADIATION: Far Infrared Radiation (5μm to 20μm wavelength)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Comparison of Two Ultra-brief Interventions in Primary Care for Patients With Anxiety, Depression, and Stress.
Status: RECRUITING
Conditions: Mental Disorder|Mental Health Issue|Mental Depression|Anxiety|Mental Stress|Rumination - Thoughts
Interventions: BEHAVIORAL: RNT-ACT Protocol|BEHAVIORAL: iCBT Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Continuous Infusion Ropivacaine Interscalene Blocks
Status: COMPLETED
Conditions: Full-thickness Rotator Cuff Tear
Interventions: PROCEDURE: Arthroscopic Rotator Cuff Repair|DRUG: Ropivacaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Abrocitinib for Reducing Pruritus in Adults With Prurigo Nodularis and Chronic Pruritus of Unknown Origin
Status: COMPLETED
Conditions: Prurigo Nodularis|Pruritus|Chronic Pruritus|Chronic Prurigo|Skin Diseases
Interventions: DRUG: Abrocitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regorafenib in Patients With Relapsed Glioblastoma. IOV-GB-1-2020 REGOMA-OSS
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Regorafenib 40 MG Oral Tablet [STIVARGA]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Achieving Patient-Centered Care and Optimized Health In Care Transitions by Evaluating the Value of Evidence
Status: COMPLETED
Conditions: Care Transitions
Interventions: BEHAVIORAL: Patient Communication and Care Management|BEHAVIORAL: Home-Based Trust, Plain Language, and Coordination|BEHAVIORAL: Hospital-Based Trust, Plain Language, and Coordination|BEHAVIORAL: Patient/Caregiver Assessment and Provider Information Exchange|BEHAVIORAL: Assessment and Teach Back|OTHER: Standard of Care (Reference)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility Study on the Use of Mindfulness-based Intervention for Family Carers of People With Dementia
Status: COMPLETED
Conditions: Anxiety|Depression|Dependency Burden|Stress, Psychological
Interventions: BEHAVIORAL: Mindfulness-Based Stress Reduction (MBSR)|BEHAVIORAL: Mindfulness-Based Cognitive Therapy (MBCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Economic Impact of the Pancreatography in the Endoscopic Treatment of Pancreatic Pseudocysts
Status: COMPLETED
Conditions: Pseudocyst Pancreas|Pancreatic Duct Disorder
Interventions: PROCEDURE: Endoscopic retrograde pancreatography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Analyzing Gait Pattern Using Insole-type Gait Analyzer in Patient With Gait Disturbance
Status: RECRUITING
Conditions: Gait Disorders, Neurologic
Interventions: DEVICE: insole-type gait analyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Nimotuzumab in Combination With Radiation Therapy in Patients With Brain Metastases
Status: TERMINATED
Conditions: Metastatic Non-Small Cell Lung Cancer
Interventions: DRUG: nimotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Adherence of Proactive Sleep Apnea Therapy
Status: NOT_YET_RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Proactive CPAP Therapy|DEVICE: Conventional APAP Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Etanercept and Rituximab in Patients With Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Etanercept|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measuring Free-living Energy Expenditure Using Direct Calorimetry
Status: COMPLETED
Conditions: Temperature|Clothing|Sex|Age|Adiposity
Interventions: BEHAVIORAL: Effects of Clothing|BEHAVIORAL: Effects of Temperature|BEHAVIORAL: Low Physical Activity|BEHAVIORAL: High Physical Activity|BEHAVIORAL: Direct calorimetry and doubly labeled water
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CBT for Insomnia With Anxiety and Depression
Status: UNKNOWN
Conditions: Insomnia
Interventions: BEHAVIORAL: Plus Cognitive behavioral therapy of insomnia（CBT-I plus）|BEHAVIORAL: Cognitive behavioral therapy of insomnia（CBT-I）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ONO-6950 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Adult Subjects
Interventions: DRUG: ONO-6950|DRUG: ONO-6950
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Bioavailability and Safety Study of Probuphine Versus Sublingual Buprenorphine in Patients With Opioid Dependence
Status: TERMINATED
Conditions: Opioid Dependence
Interventions: DRUG: Probuphine (buprenorphine implant)|DRUG: Sublingual Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Locally Delivered 1% Metformin Gel in Peri-implantitis
Status: COMPLETED
Conditions: Peri-Implantitis
Interventions: DRUG: 1% local metformin gel|PROCEDURE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nasal CPAP - The Treatment IMpact on Oxygenation in High-risk Patients During Deep Sedation for Endoscopy
Status: ACTIVE_NOT_RECRUITING
Conditions: Continuous Positive Airway Pressure|Endoscopy|Oxygenation|Obesity
Interventions: DEVICE: SuperNO2VA™ Et by Vyaire Medical, Inc.|DEVICE: nasal oxygen cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Sildenafil on CFTR-dependent Ion Transport Activity
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Sildenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Persistence of Antibodies After Vaccination With Meningococcal Vaccine GSK134612
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: Meningococcal vaccine GSK134612|BIOLOGICAL: Meningitec™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants
Status: RECRUITING
Conditions: Patent Ductus Arteriosus After Premature Birth
Interventions: DRUG: Acetaminophen Injection|DRUG: Ibuprofen 20 mg/mL oral suspension or Ibuprofen lysine 10 mg/mL injection solution (Neoprofen)|OTHER: Sodium chloride 0.9% injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Accuracy of Trephination-based Versus Drilling-based Guided Dental Implant Placement
Status: COMPLETED
Conditions: Single Tooth Lost|Partially Edentulous Maxilla
Interventions: PROCEDURE: guided trephination-based drilling protocol|PROCEDURE: guided Conventional drilling-based protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hepatic Impairment With Cirrhosis Due to Cholestatic Liver Disease
Status: RECRUITING
Conditions: Hepatic Impairment|Cirrhosis|Cholestatic Liver Disease
Interventions: DRUG: Saroglitazar Magnesium 1 mg|DRUG: Saroglitazar Magnesium 2 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Pain Relief Between Adductor Canal Block and Femoral Nerve Block in Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Osteoarthritis
Interventions: PROCEDURE: Sono guided nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab and Ipilimumab in T1aN0M0 Renal Cell Carcinoma Patients Ineligible for Surgical Treatment.
Status: UNKNOWN
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients
Status: RECRUITING
Conditions: Neuroendocrine Neoplasm|Neuroendocrine Neoplasm of Gastrointestinal Tract|Neuroendocrine Neoplasm of Lung|Thymic Neuroendocrine Neoplasm|Neuroendocrine Tumor of Pancreas|Gastrointestinal Stromal Tumors|Medullary Thyroid Cancer|Paraganglioma|Pheochromocytoma|Primary Hyperparathyroidism|Pituitary Tumor|Multiple Endocrine Neoplasia Type 1|Multiple Endocrine Neoplasia Type 2|Multiple Endocrine Neoplasia Type 4|Carney Complex|Carney Stratakis Dyad|Carney Triad|Cowden Syndrome|DICER1 Syndrome|Li-Fraumeni Syndrome|Lynch Syndrome|Von Hippel-Lindau Disease|Familial Isolated Pituitary Adenoma|X-Linked Acrogigantism|Neurofibromatosis 1|Tuberous Sclerosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of Plyometric on Physical Fitness and Technical Skills of Football Players
Status: RECRUITING
Conditions: Physical Fitness and Technical Skills
Interventions: OTHER: Plyometric Exercises|OTHER: Conventional Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Covered Stents Versus Bare-Metal Stents
Status: UNKNOWN
Conditions: Gastrointestinal Vascular Conditions|Arteriosclerosis|Lifestyle-related Condition|Stenosis|Vascular Insufficiency|Necrosis
Interventions: DEVICE: Covered stent (Atrium Type V12)|DEVICE: Bare stent (Brand Cordis Type Palmaz Blue)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of PNF-Based Upper Extremity Strengthening With Core Stabilization on Fitness in Amputee Football Players
Status: NOT_YET_RECRUITING
Conditions: Amputation|Lower Limb Amputation
Interventions: OTHER: Training|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endovascular Thrombectomy With and Without Intravenous Thrombolysis in Extended Time Window
Status: RECRUITING
Conditions: Stroke, Acute Ischemic
Interventions: DRUG: Intravenous thrombolysis agents|PROCEDURE: endovascular thrombectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peak Bronchoprotection Conferred by Levosalbutamol and Racemic Salbutamol
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: levosalbutamol|DRUG: racemic salbutamol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PTNS vs Botox of Refractory OAB
Status: TERMINATED
Conditions: Overactive Bladder (OAB)
Interventions: BIOLOGICAL: OnabotulinumtoxinA (BoNTA)|PROCEDURE: Percutaneous tibial nerve stimulation (PTNS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fludarabine or Observation in Treating Patients With Stage 0, Stage I, or Stage II Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient's Satisfaction of Bispectral Index-guided Monitored Anesthesia Care
Status: TERMINATED
Conditions: Bispectral Index, Monitored Anesthesia Care
Interventions: DEVICE: Titration under the guidance of BIS|DIAGNOSTIC_TEST: Titration under the guidance of OAA/S
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Hemostatic Potential in Sickle Cell Disease Patients
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: OTHER: Blood sampling - healthy volunteers|OTHER: Blood sampling - sickle cell patients arm - stable condition|OTHER: Blood sampling - sickle cell patients arm- exsanguinotransfusion needed|OTHER: Blood sampling - sickle cell patients arm - vaso-occlusive crisis.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate Time in Range in Type 2 Diabetics Using Afrezza® Plus Basal Insulin Compared to Multiple Daily Injections
Status: UNKNOWN
Conditions: Type 2 Diabetes Treated With Insulin
Interventions: DRUG: Afrezza Inhalant Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dasatinib (Sprycel™) in Patients With Newly Diagnosed Core Binding Factor (CBF) Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: Dasatinib|DRUG: daunorubicin|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Use of Polymyxin B Hemoperfusion in Abdominal Sepsis
Status: COMPLETED
Conditions: Gram-Negative Bacterial Infections|Sepsis|Septic Shock
Interventions: DEVICE: Polymyxin B immobilized fiber column|OTHER: Conventional medical therapy in the ICU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modified Atkins Diet Plus KetoCal for Adult Epilepsy
Status: COMPLETED
Conditions: Epilepsy|Seizure|Medically Resistant Epilepsy|Medically Resistant Seizures
Interventions: DIETARY_SUPPLEMENT: Modified Atkins diet|DIETARY_SUPPLEMENT: KetoCal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Single Maxillary Gingival Recession With Loss of Inter-dental Attachment. A Randomized Controlled Clinical Trial
Status: COMPLETED
Conditions: Gingival Recession
Interventions: OTHER: CAF+CTG|OTHER: CAF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eribulin in Combination With Capecitabine for Adjuvant Treatment in Estrogen Receptor-Positive Early Stage Breast Cancer
Status: COMPLETED
Conditions: Estrogen Receptor Positive Tumor|Breast Cancer
Interventions: DRUG: eribulin mesylate|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total Neoadjuvant Treatment vs. Chemoradiotherapy in Local Advanced Rectal Cancer With High Risk Factors
Status: UNKNOWN
Conditions: Total Neoadjuvant Treatment|Chemoradiotherapy|Local Advanced Rectal Cancer|High Risk Factors
Interventions: RADIATION: Total neoadjuvant treatment|RADIATION: concurrent chemoradiotherapy|PROCEDURE: TME|DRUG: Adjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rifampin Combination Therapy Versus Monotherapy in Early Staphylococcal Infections After Total Hip and Knee Arthroplasty
Status: UNKNOWN
Conditions: Prosthesis-related Infections|Staphylococcal Infections
Interventions: DRUG: Rifampin-combination therapy|DRUG: Monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing High-Dose Flu Vaccine to Standard Vaccine in Cancer Patients Less Than 65 Receiving Chemotherapy
Status: COMPLETED
Conditions: Cancer|Influenza Viral Infections
Interventions: BIOLOGICAL: Standard Trivalent Influenza Vaccine|BIOLOGICAL: High-Dose Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Anti-CD19/BCMA Bispecific CAR-T Cell Therapy for R/R POMES
Status: UNKNOWN
Conditions: POMES Syndrome|Relapsed and Refractory POMES Syndrome
Interventions: BIOLOGICAL: anti-CD19/BCMA CAR-T cells|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase IIIB Study Evaluating the Effect on Serum Lipids Following a Switch to Atazanavir in HIV Infected Subjects Evidencing Virologic Suppression on Their First PI-Based Antiretroviral Therapy
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Atazanavir (immediate switch)|DRUG: Atazanavir (Week 24 switch)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of an Infant Formula With Hydrolysed Protein in Term Infants
Status: COMPLETED
Conditions: Growth
Interventions: OTHER: Intervention Group: Infant Formula with hydrolyzed protein|OTHER: Control Group: Infant Formula with intact protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Acupuncture for Female IC/PBSyndrome and Its Effect on the Urinary Microbiome: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Painful Bladder Syndrome|Interstitial Cystitis
Interventions: DEVICE: standard acupuncture treatment|DEVICE: Control Sham/Minimal Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of rTMS on the Cognition of Elderly With Mild Memory Complaints
Status: UNKNOWN
Conditions: Mild Cognitive Impairment
Interventions: DEVICE: Repetitive transcranial magnetic stimulation|DEVICE: Repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prolgolimab 250 mg Q3W in Patients With Unresectable or Metastatic Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Unresectable or Metastatic Melanoma
Interventions: DRUG: Prolgolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Squalamine Lactate for Injection (MSI-1256F) for "Wet" Age-Related Macular Degeneration
Status: TERMINATED
Conditions: "Wet" Age-Related Macular Degeneration
Interventions: DRUG: Squalamine Lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Role of Biomarkers in Endometrial Cancer Recurrence in Samples From Patients With Stage II, Stage III, or Stage IV Endometrial Cancer
Status: UNKNOWN
Conditions: Endometrial Cancer
Interventions: GENETIC: RNA analysis|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: enzyme-linked immunosorbent assay|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Breast Cancer Neoantigen Vaccination With Autologous Dendritic Cells
Status: COMPLETED
Conditions: Breast Cancer|Triple Negative Breast Cancer
Interventions: BIOLOGICAL: Neo-antigen pulsed Dendritic cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dovitinib Lactate in Treating Patients With Pancreatic Neuroendocrine Tumors
Status: WITHDRAWN
Conditions: Gastrinoma|Glucagonoma|Insulinoma|Pancreatic Polypeptide Tumor|Recurrent Islet Cell Carcinoma|Somatostatinoma
Interventions: DRUG: dovitinib lactate|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neo-adjuvant Chemo + Peritonectomy + Hyperthermic Intraperitoneal Chemo in Peritoneal Carcinomatosis From Gastric Cancer
Status: COMPLETED
Conditions: Peritoneal Carcinomatosis|Gastric Cancer
Interventions: DRUG: Multimodal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction Modified TPF Followed by Concurrent Chemoradiotherapy in Locally Advanced Squamous Cell Carcinoma of the Head and Neck
Status: RECRUITING
Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: modified TPF|OTHER: Quality of life assessment (QoL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Putting Patients at the Center of Kidney Care Transitions (PREPARE NOW)
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: OTHER: Patient-Centered Kidney Transitions Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase 1/2 Trial of CLN-081 in Patients With Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer|EGFR Exon 20 Mutation
Interventions: DRUG: CLN-081
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decannulation of Tracheostomy Cannula Based on Suctioning Frequency and High-flow Oxygen Protocol in the Intensive Care Unit
Status: NOT_YET_RECRUITING
Conditions: Tracheostomy Weaning
Interventions: PROCEDURE: Suctioning based protocol|PROCEDURE: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computerized Cognitive Training for Patients With Epilepsy
Status: WITHDRAWN
Conditions: Epilepsy
Interventions: BEHAVIORAL: Luminosity Trial Memory Match|BEHAVIORAL: Luminosity Trial Memory Matrix|BEHAVIORAL: Luminosity Trial Famliar Faces|BEHAVIORAL: Luminosity Trial Brain Shift|BEHAVIORAL: Luminosity Trial Star Search|BEHAVIORAL: Luminosity Trial Word Bubbles|BEHAVIORAL: Luminosity Trial Color Match|BEHAVIORAL: Luminosity Trial Ebb and Flow|BEHAVIORAL: Luminosity TrialChalk Board Challenge|BEHAVIORAL: Luminosiuty Follow that Frog|BEHAVIORAL: Luminosity Train of Thought
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy, Plasma Exchange, and Immunotherapy (Pembrolizumab or Nivolumab) for the Treatment of Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: Pembrolizumab|RADIATION: Radiation Therapy|BIOLOGICAL: Therapeutic Exchange Plasma|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Positron Emission Tomography|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Silent Cerebral Thromboembolism by Oral Anticoagulation With Dabigatran After Pulmonary Vein Isolation for Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation|Cardioembolic Events|Oral Anticoagulation
Interventions: DRUG: Dabigatran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Sleep Therapy and Biomarkers in Children With Autism Spectrum Disorders
Status: TERMINATED
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Melatonin and Donepezil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TMS for Investigating Memory Facilitation
Status: TERMINATED
Conditions: Age-associated Memory Impairment
Interventions: DEVICE: Transcranial Magnetic Stimulation (TMS) Cone Coil|DEVICE: Transcranial Magnetic Stimulation (TMS) Sham Coil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: First in Man Study of Left Atrial Appendage Pulsed Field Ablation Occluder
Status: RECRUITING
Conditions: Nonvalvular Atrial Fibrillation
Interventions: DEVICE: E-SeaLA, CardioPulse PFA system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: International Rare Histiocytic Disorders Registry (IRHDR)
Status: ACTIVE_NOT_RECRUITING
Conditions: Rare Histiocytic Disorders (RHDs)|Juvenile Xanthogranuloma (JXG)|Reticulohistiocytoma (Epithelioid Histiocytoma)|Xanthoma Disseminatum (XD)|Multicentric Reticulohistiocytosis (MRH)|Systemic Juvenile Xanthogranuloma|Erdheim-Chester Disease (ECD)|Multi-system Rosai-Dorfman Disease (RDD)
Interventions: OTHER: Registry study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dimethyl Fumarate (DMF) in Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Status: TERMINATED
Conditions: Systemic Sclerosis|Pulmonary; Hypertension
Interventions: DRUG: Dimethyl Fumarate (DMF)|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraperitoneal Techniques of Local Anaesthesia During Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Gall Stones
Interventions: DRUG: Bupivocaine|DRUG: 0.9% normal saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Overcome, a Program of Therapeutic Exercise and Functional Recovery to Improve the Functional Capacity of Women With Breast Cancer and Bone Metastases
Status: RECRUITING
Conditions: Breast Neoplasm Female|Neoplasm Metastasis|Spinal Neoplasms
Interventions: OTHER: Overcome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antibiotics for Postpartum Third and Fourth Degree Perineal Tear Repairs
Status: COMPLETED
Conditions: Pregnancy Complications, Infectious
Interventions: DRUG: Cefotetan or Cefoxitin vs placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: SU011248 in Patients With Metastatic Mucosal or Acral/Lentiginous Melanoma
Status: COMPLETED
Conditions: Mucosal Lentiginous Melanoma|Acral Lentiginous Malignant Melanoma
Interventions: DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardioneuroablation for Neurocardiogenic Syncope
Status: COMPLETED
Conditions: Neurocardiogenic Syncope|Vasovagal Syncope
Interventions: PROCEDURE: Cardioneuroablation|DEVICE: Biosense Webster Navistar ThermoCool Diagnostic/Ablation Deflectable Tip Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TAC-101 in Combination With TACE Versus TACE Alone in Asian Patients With Advanced Hepatocellular Carcinoma
Status: WITHDRAWN
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DRUG: TAC-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimized Anesthesia to Reduce Postoperative Cognitive Impairment in the Elderly
Status: COMPLETED
Conditions: Elderly ; Moderate Risk Surgery
Interventions: DEVICE: Depth of anesthesia monitoring (BIS, Covidien USA) and Continus non invasive blood pressure monitoring (Clearsight, Edwards LifeScience, USA)|PROCEDURE: moderate risk surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION