pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: GSK2190915A - Bioavailability Study
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: GSK2190915 Solution.|DRUG: GSK2190915 Granule Capsule (A)|DRUG: GSK2190915 Semi-solid Lipid Capsule (B)|DRUG: GSK2190915 Liquid Lipid Capsule (C)|DRUG: GSK2190915 Milled Tablet|DRUG: GSK2190915 Micronised Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Postoperative Effects of Chewing Gum, Ibuprofen and Acetaminophen on Pain After Initial Archwire Placement
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Ibuprofen|DRUG: Acetaminophen|OTHER: Chewing gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Antioxidant Supplementation on the Autonomic Balance
Status: COMPLETED
Conditions: Hypertension|Oxidative Stress|Autonomic Imbalance|Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: Antioxidants capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: ChronoFOLFOX Plus Avastin for Patients With Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Neoplasms
Interventions: DRUG: 5-Fluorouracil, leucovorin, oxaliplatin, avastin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Eye Bank Pre-cut Donor Grafts for Endothelial Keratoplasty
Status: COMPLETED
Conditions: Fuchs Endothelial Dystrophy|Corneal Edema
Interventions: PROCEDURE: Descemet's stripping endothelial keratoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Microsphere-Delivered Cytokines in Increasing Tumor Response in Lymphocytes From Patients With Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: recombinant interleukin-12|BIOLOGICAL: sargramostim|OTHER: immunologic technique|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: LEE011 (Ribociclib) in Combination With Docetaxel Plus Prednisone in mCRPC
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Docetaxel-PNP|DRUG: Ribociclib|DRUG: Prednisone|DRUG: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: This Study is Done in Healthy Japanese Volunteers. It Looks at How Different Doses of BI 730357 Are Taken up in the Body and How Well They Are Tolerated
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 730357|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Post-marketing Clinical Follow-up for Long-term Use of Intranasal Kinetic Oscillation in Subjects With Chronic Migraine
Status: RECRUITING
Conditions: Chronic Migraine
Interventions: DEVICE: KOS (Intranasal kinetic oscillation stimulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Pilot Randomized Controlled Trial for Antibiotic Exposure in Neonatal Sepsis Using Neutrophil CD64
Status: WITHDRAWN
Conditions: Neonatal Early-onset Sepsis|Neonatal Late-onset Sepsis
Interventions: OTHER: Intervention is to stop antibiotics at 24h .
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Bevacizumab for Management of Active Progressive Proliferative Diabetic Retinopathy (PDR)
Status: UNKNOWN
Conditions: Diabetic Retinopathy
Interventions: DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Recurrent or Refractory Leukemia or Lymphoma
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: sargramostim|DRUG: cytarabine|DRUG: mitoxantrone hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amniotomy and Oxytocin for Augmentation of Labour
Status: COMPLETED
Conditions: Prolonged Labor
Interventions: PROCEDURE: Amniotomy first|PROCEDURE: Oxytocin first|PROCEDURE: Amniotomy and oxytocin|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gem-TABS in Unresectable Pancreatic Carcinoma
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Sodium bicarbonate (g/kg/day)|DRUG: Gemcitabine (mg/m²)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept Study of Vagus Nerve Stimulation
Status: COMPLETED
Conditions: Transcutaneous Vagal Nerve Stimulation (tVNS)|Prader-Willi Syndrome
Interventions: DEVICE: Transcutaneous vagus nerve stimulation (tVNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Apaziquone vs. Placebo in Patients With Non-Muscle Invasive Bladder Cancer (NMIBC)
Status: TERMINATED
Conditions: Bladder Cancer
Interventions: DRUG: Apaziquone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of SGN-STNV in Advanced Solid Tumors
Status: TERMINATED
Conditions: Carcinoma, Non-Small Cell Lung|HER2 Negative Breast Neoplasms|Ovarian Neoplasms|Uterine Cervical Neoplasms|Endometrial Neoplasms|Esophageal Neoplasms|Gastroesophageal Junction Carcinoma|Stomach Neoplasms|Colorectal Neoplasms|Exocrine Pancreatic Adenocarcinoma|Appendiceal Adenocarcinoma|Pseudomyxoma Peritonei
Interventions: DRUG: SGN-STNV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Capadenoson in Angina Pectoris
Status: WITHDRAWN
Conditions: Chronic Stable Angina
Interventions: DRUG: Capadenoson (BAY 68-4986)|DRUG: Capadenoson (BAY 68-4986)|DRUG: Capadenoson (BAY 68-4986)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of C-reactive Protein Testing
Status: COMPLETED
Conditions: Fever
Interventions: OTHER: No CRP will be measured onsite|OTHER: CRP cut-off of 20mg/L.|OTHER: CRP cut-off of 40mg/L.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study of the Combination of a Tyrosine Kinase Inhibitor (STI571) and a Pegylated Human Recombinant Interferon alfa2b (PEGINTRON)
Status: TERMINATED
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: STI571 and PEG INTRON
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation Of The Efficacy of a Strain-Specific Probiotic Formulation in Hemodialysis Patients
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DIETARY_SUPPLEMENT: Probiotic packet|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Steroid-eluting Stent Implant for the Treatment of Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
Status: UNKNOWN
Conditions: Patients|Sinusitis|Nasal Polyps
Interventions: PROCEDURE: Steroid-eluting stent implant|PROCEDURE: Without Steroid-eluting stent implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bromfenac Sodium Hydrate Eye Drops in Familial Exudative Vitreoretinopathy
Status: RECRUITING
Conditions: Familial Exudative Vitreoretinopathies
Interventions: DRUG: Bromfenac Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Taselisib + Fulvestrant Versus Placebo + Fulvestrant in Participants With Advanced or Metastatic Breast Cancer Who Have Disease Recurrence or Progression During or After Aromatase Inhibitor Therapy
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Taselisib|DRUG: Placebo|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Bone Marrow Mononuclear Cell Layer Seeded on Platelet-rich Fibrin on an Alveolar Socket After Extraction
Status: UNKNOWN
Conditions: Decayed Teeth
Interventions: OTHER: bone marrow aspiration from maxillary tuberosity and BMMNCs separation to be seeded on PRF and used for socket preservation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect Of Pumpkin Seed Extract Capsules On Nutritional Status and Haemoglobin Level in Pregnant Women.
Status: RECRUITING
Conditions: Anemia During Pregnancy
Interventions: DIETARY_SUPPLEMENT: Pumpkin seeds extract capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Flaxseed(Alpha Linolenic Acid) Powder in Morbidly Obese Patients With Systemic Inflammation
Status: UNKNOWN
Conditions: Morbid Obesity|Atherosclerosis|Systemic Inflammation
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Alpha-linolenic acid/ALA|DIETARY_SUPPLEMENT: Alpha linolenic acid/ALA|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Substance Use Disorder (SUD)-Associated Infections' Treatment With Dalbavancin ENabling OUtpatient Transition
Status: TERMINATED
Conditions: Gram-Positive Bacterial Infections|Gram-Positive Bacteraemia|Substance Use Disorders|Intravenous Substance Abuse
Interventions: DRUG: Dalbavancin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hippocampal Sclerosis and Amnesia Not Due to Alzheimer's Disease
Status: COMPLETED
Conditions: Patients With Cognitive Disturbances
Interventions: OTHER: Neurological examinations|OTHER: Neuropsychological examinations|OTHER: Clinical examinations|RADIATION: MRI 3T|RADIATION: MRI 7T
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Music Intervention Combined With Progressive Muscle Relaxation in Cancer Patients
Status: COMPLETED
Conditions: Cancer
Interventions: OTHER: progressive muscle relaxation|OTHER: Listening to relaxing music once/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cognitive Flexibility Training for Persistent Pain: Neuroimaging Pilot (COFLEX-i)
Status: COMPLETED
Conditions: Chronic Pain|Knee Pain Chronic|Hip Pain Chronic|Back Pain
Interventions: BEHAVIORAL: Cognitive Training + fMRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Gastrografin for Treating Small Bowel Obstruction in Children
Status: TERMINATED
Conditions: Small Bowel Obstruction
Interventions: DRUG: Gastrograﬁn|OTHER: Saline solution (control treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Signposting to Online Peer Support Helpful in Decreasing Loneliness in Parents of Children With Long-term Conditions and Disabilities?
Status: COMPLETED
Conditions: Loneliness|Anxiety|Anxiety Disorder|Depression|Low Mood
Interventions: BEHAVIORAL: Online Peer Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can We Predict of the Response of High Risk Non Muscle Invasive Bladder Cancer Patients to Intravesical Bacillus Calmette-Guerin? The Role of Immunological Markers
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DIAGNOSTIC_TEST: Urine ELISA for immunological markers (IL-2 and IL-10)|DIAGNOSTIC_TEST: Reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sublingual Cockroach Safety in Adults With Cockroach Allergy & Perennial Allergic Rhinitis With or Without Asthma
Status: COMPLETED
Conditions: Allergy|Asthma
Interventions: DRUG: Glycerinated German cockroach allergenic extract|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KN046 Plus Regorafenib or Apatinib in MSI-H Digestive System Cancers Resistant to PD-1/PD-L1 Blockade
Status: RECRUITING
Conditions: Digestive System Cancers
Interventions: DRUG: KN046|DRUG: Regorafenib|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study To Evaluate The Efficacy And Safety Of TNX-102 SL In Patients With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: TNX-102 SL|DRUG: Placebo SL Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Effects of High-dose Statin and Trimetazidine on Patients With Aspirin Mono Antiplatelet Therapy 12-months After Coronary Artery Bypass Surgery
Status: COMPLETED
Conditions: Coronary Artery
Interventions: DRUG: Pravastatin 20mg/day for 12 months after randomization|DRUG: Atorvastatin 40 mg and trimetazidine MR 70 mg/day for 12 months after randomization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Epinastine Nasal Spray in Subjects With Seasonal Allergic Rhinitis (P08648)
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: epinastine nasal spray, low concentration, low dose volume|OTHER: placebo nasal spray|DRUG: epinastine nasal spray, low concentration, high dose volume|DRUG: epinastine nasal spray, high concentration, low dose volume|DRUG: epinastine nasal spray, high concentration, high dose volume
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Placebo Controlled Double Masked Clinical Assessment Study of Essential Fatty Acid Supplement and Its Effect on Patients With Apparent Aqueous Deficient Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DIETARY_SUPPLEMENT: Omega-3 fatty acid supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating S 95005 Plus Bevacizumab and Capecitabine Plus Bevacizumab in Patients With Previously Untreated Colorectal Cancer Who Are Non-eligible for Intensive Therapy
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Trifluridine/tipiracil + bevacizumab|DRUG: Capecitabine + bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-Molecular-Weight Heparin (LMWH) for Deep Venous Thrombosis (DVT) Prophylaxis
Status: UNKNOWN
Conditions: Deep Venous Thrombosis
Interventions: DRUG: Low-Molecular-Weight Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Mepolizumab Adjunctive Therapy in Subjects With Severe Uncontrolled Refractory Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Mepolizumab IV|DRUG: Mepolizumab SC|DRUG: IV Placebo|DRUG: SC Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD)
Status: RECRUITING
Conditions: Opioid-use Disorder
Interventions: DEVICE: Exablate Model 4000 Type 2.0/2.1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ipilimumab, Cetuximab, and Intensity-Modulated Radiation Therapy in Treating Patients With Previously Untreated Stage III-IVB Head and Neck Cancer
Status: COMPLETED
Conditions: Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7|Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7|Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVA Hypopharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7|Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVB Hypopharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVB Laryngeal Squamous Cell Carcinoma AJCC v7|Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7
Interventions: BIOLOGICAL: Cetuximab|RADIATION: Intensity-Modulated Radiation Therapy|BIOLOGICAL: Ipilimumab|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single and Multiple Dose Study to Explore the Safety and Pharmacokinetics of JNJ-39758979 In Healthy Male Volunteers of Either Caucasian or Japanese Descent
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: single dose NJ-39758979/ matching placebo|DRUG: multi-dose JNJ-39758979 /matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Clinical Evaluation of the Pharmacokinetics and Mechanism Based Pharmacodynamics of Haloperidol Using Positron Emission Tomography in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: haloperidol, PET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: High-definition Transcranial Electrical Stimulation for Lower Limb Stroke Rehabilitation
Status: RECRUITING
Conditions: Stroke
Interventions: DEVICE: HD-tCES|DEVICE: Sham HD-tCES|OTHER: Lower limb rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Drug-Drug Interaction Study of LY3537982 on Midazolam, Digoxin, and Rosuvastatin in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3537982|DRUG: Digoxin|DRUG: Rosuvastatin|DRUG: Midazolam|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility and Outcomes of Older Patients Hospitalization
Status: UNKNOWN
Conditions: Community-Acquired Pneumonia|Exacerbation of Chronic Heart Failure|Exacerbation of Chronic Obstructive Pulmonary Disease|Cellulitis
Interventions: PROCEDURE: sub-acute hospitalization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of RNS60 on the Late Phase Asthmatic Response to Allergen Challenge
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: RNS60|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antiischemic Effects of Empagliflozin in Diabetic Patients With Refractory Angina
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Empagliflozin 25 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glucose Control During Glucocorticoid Therapy in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Hyperglycemia Steroid-induced
Interventions: DRUG: Dapagliflozin|DRUG: Sliding scale insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remote Ischemic Conditioning of the Human Brain in Dementia Patients
Status: UNKNOWN
Conditions: Mild Cognitive Impairment|Dementia|Intermittent Claudication
Interventions: BEHAVIORAL: Leg ischemia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relacorilant Food Effect Study in Healthy Subjects
Status: COMPLETED
Conditions: Healthy|Food-drug Interaction
Interventions: DRUG: Relacorilant Fasted|DRUG: Relacorilant with a high fat breakfast|DRUG: Relacorilant with a moderate breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: High-Density (HD) Wave Mapping in Subjects With Atrial Fibrillation as a Predictor of Recurrence After a Single Ablation Procedure Using a PVI-Only Strategy
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation|Persistent Atrial Fibrillation|Cardiac Arrhythmia
Interventions: PROCEDURE: A specific electrophysiology mapping protocol is applicable with the GRID catheter.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Safety, Tolerability and Pharmacokinetics Study of Topical Ointment YR001 in Adult Healthy Volunteers
Status: COMPLETED
Conditions: Atopic Dermatitis|Psoriasis
Interventions: DRUG: YR001 Dose A on low body surface area|DRUG: YR001 Dose A on middle body surface area|DRUG: YR001 Dose A on high body surface area|DRUG: YR001 Dose B on low body surface area|DRUG: YR001 Dose B on middle body surface area|DRUG: YR001 Dose B on high body surface area|DRUG: Placebo on low body surface area|DRUG: Placebo on middle body surface area|DRUG: Placebo on high body surface area|DRUG: YR001 Dose A on high body surface area twice daily|DRUG: YR001 Dose B on high body surface area twice daily|DRUG: Placebo on high body surface area twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bronchoscopic Thermal Saline Ablation (BTSA) of Emphysematous Lung. A New Emphysema Therapy
Status: UNKNOWN
Conditions: Emphysema
Interventions: PROCEDURE: Endoscopic lung volume reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: WaKING: Wnt and checKpoint INhibition in Gastric Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Esophageal Cancer|Metastatic Gastric Cancer
Interventions: DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Clinical Study on the Safety and Efficacy of Radiofrequency Ablation for the Treatment of Patients With Desmoid Tumors
Status: NOT_YET_RECRUITING
Conditions: Desmoid Tumor|Desmoid Fibromatosis|Desmoid
Interventions: PROCEDURE: radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Assess Treatment of Patients With Homogeneous Emphysema Using Sequential Segmental Bronchoscopic Thermal Vapor Ablation (NEXT STEP)
Status: COMPLETED
Conditions: Emphysema or COPD
Interventions: DEVICE: Bronchoscopic Thermal Vapor Ablation (BTVA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Longitudinal Effectiveness of HEART Smartphone- Based Videoconferencing Program in Enhancing Residents and Family'Health
Status: COMPLETED
Conditions: Communication|Health Behavior
Interventions: BEHAVIORAL: a web-based Relationship Teaching(RT)/communication education programs|BEHAVIORAL: Helper of Emotional Assessment Relationship Teaching (HEART) program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hydroxychloroquine, Azithromycin in the Treatment of Covid-19
Status: UNKNOWN
Conditions: SARS-CoV-2 Pneumonia|COVID-19
Interventions: DRUG: Hydroxychloroquine 200 Mg Oral Tablet|DRUG: Azithromycin 250 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Artichoke and Bergamot Phytosome
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: Combined Bergamot phytosome and Artichoke leaf dry extract|COMBINATION_PRODUCT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Paravertebral Block for Improvement of Quality of Recovery Following Cardiac Surgery
Status: RECRUITING
Conditions: Post-operative Pain|Post-cardiac Surgery|Cardiac Disease
Interventions: PROCEDURE: Bilateral paravertebral block with 0.25% ropivicaine with 1:400,000 epinephrine|PROCEDURE: Bilateral sham block with normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Study of ALN-TTR02 (Patisiran) for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis in Patients Who Have Already Been Treated With ALN-TTR02 (Patisiran)
Status: COMPLETED
Conditions: TTR-mediated Amyloidosis
Interventions: DRUG: ALN-TTR02 (patisiran) administered by intravenous (IV) infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional and Radiographic Outcomes of Hallux Valgus Correction by Mini-invasive Surgery With Reverdin-Isham Percutaneous Osteotomy
Status: COMPLETED
Conditions: Hallux Valgus
Interventions: PROCEDURE: Reverdin-Isham Osteotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Drug Interaction (DDI) Between Supaglutide and Digoxin or Metformin
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Supaglutide injection|DRUG: Digoxin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: OFDI-Quantified Intracoronary Thrombus, Antiplatelet Pretreatment Effect and Myocardial Reperfusion
Status: COMPLETED
Conditions: Myocardial Infarction|Thrombosis, Coronary
Interventions: DIAGNOSTIC_TEST: optical coherence tomography and VerifyNow
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fasting and Nutritional Therapy in Patients With Advanced Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Fasting|Prostatic Neoplasms
Interventions: OTHER: Fasting|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Carboplatin, Gemcitabine Hydrochloride, and Mifepristone in Treating Patients With Advanced Breast Cancer or Recurrent or Persistent Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Male Breast Cancer|Recurrent Breast Cancer|Recurrent Fallopian Tube Cancer|Recurrent Ovarian Epithelial Cancer|Recurrent Primary Peritoneal Cavity Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: mifepristone|DRUG: carboplatin|DRUG: gemcitabine hydrochloride|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Rehabilitation With Technology-Based Systems in Adolescent Idiopathic Scoliosis
Status: NOT_YET_RECRUITING
Conditions: Scoliosis; Adolescence
Interventions: OTHER: Conservative Approach|OTHER: Rehabilitative Game Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Transcranial Electrical Stimulation in Stroke Individuals
Status: RECRUITING
Conditions: Ischemic Stroke|Hemorrhagic Stroke|Chronic Stroke|Subacute Stroke
Interventions: DEVICE: transcranial direct current stimulation (Active)|DEVICE: transcranial alternating current stimulation (active)|DEVICE: transcranial electrical stimulation (sham)|OTHER: Conventional physical therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Halliwick Concept on Motor Functions in Spastic CP
Status: COMPLETED
Conditions: Spastic Cerebral Palsy|Spastic Hemiplegic Cerebral Palsy
Interventions: OTHER: Aquatic Halliwick method|PROCEDURE: Conventional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of add-on Doxofylline on Lung Function in Stable COPD
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Doxofylline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tanespimycin in Treating Young Patients With Recurrent or Refractory Leukemia or Solid Tumors
Status: COMPLETED
Conditions: Childhood Chronic Myelogenous Leukemia|Childhood Desmoplastic Small Round Cell Tumor|Disseminated Neuroblastoma|Metastatic Childhood Soft Tissue Sarcoma|Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Metastatic Osteosarcoma|Previously Treated Childhood Rhabdomyosarcoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Rhabdomyosarcoma|Recurrent Childhood Soft Tissue Sarcoma|Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Recurrent Neuroblastoma|Recurrent Osteosarcoma
Interventions: DRUG: tanespimycin|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy
Status: COMPLETED
Conditions: Cognitive Side Effects of Cancer Therapy|Malignant Ovarian Epithelial Tumor|Ovarian Brenner Tumor|Ovarian Carcinosarcoma|Ovarian Choriocarcinoma|Ovarian Clear Cell Cystadenocarcinoma|Ovarian Dysgerminoma|Ovarian Embryonal Carcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Mixed Germ Cell Tumor|Ovarian Mucinous Cystadenocarcinoma|Ovarian Polyembryoma|Ovarian Sarcoma|Ovarian Seromucinous Carcinoma|Ovarian Serous Cystadenocarcinoma|Ovarian Teratoma|Ovarian Yolk Sac Tumor|Stage I Ovarian Cancer|Stage IA Fallopian Tube Cancer|Stage IA Ovarian Cancer|Stage IA Ovarian Germ Cell Tumor|Stage IB Fallopian Tube Cancer|Stage IB Ovarian Cancer|Stage IB Ovarian Germ Cell Tumor|Stage IC Fallopian Tube Cancer|Stage IC Ovarian Cancer|Stage IC Ovarian Germ Cell Tumor|Stage II Ovarian Cancer|Stage IIA Fallopian Tube Cancer|Stage IIA Ovarian Cancer|Stage IIA Ovarian Germ Cell Tumor|Stage IIB Fallopian Tube Cancer|Stage IIB Ovarian Cancer|Stage IIB Ovarian Germ Cell Tumor|Stage IIC Fallopian Tube Cancer|Stage IIC Ovarian Cancer|Stage IIC Ovarian Germ Cell Tumor|Stage IIIA Fallopian Tube Cancer|Stage IIIA Ovarian Cancer|Stage IIIA Ovarian Germ Cell Tumor|Stage IIIA Primary Peritoneal Cancer|Stage IIIB Fallopian Tube Cancer|Stage IIIB Ovarian Cancer|Stage IIIB Ovarian Germ Cell Tumor|Stage IIIB Primary Peritoneal Cancer|Stage IIIC Fallopian Tube Cancer|Stage IIIC Ovarian Cancer|Stage IIIC Ovarian Germ Cell Tumor|Stage IIIC Primary Peritoneal Cancer|Stage IV Fallopian Tube Cancer|Stage IV Ovarian Cancer|Stage IV Ovarian Germ Cell Tumor|Stage IV Primary Peritoneal Cancer|Undifferentiated Ovarian Carcinoma
Interventions: PROCEDURE: Cognitive Assessment|OTHER: Quality-of-Life Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CD40 Agonist and PD-1 Inhibitor in HNSCC
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: PD-1inhibitor - LVGN 3616|DRUG: CD 40 Agonist - LVGN 7409
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liver Transplantation With ADV-TK Gene Therapy Improves Survival in Patients With Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Liver Transplantation
Interventions: GENETIC: ADV-TK (adenovirus-thymidine kinase enzyme) gene therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiotherapy (SBRT) Versus Sublobar Resection for High-Risk Patients Non-Small Lung Cancer
Status: TERMINATED
Conditions: Lung Neoplasms
Interventions: PROCEDURE: Sublobar Resection|RADIATION: Stereotactic Body Radiotherapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Establishment of an ex Vivo Tumor Collection of Triple-negative Breast Cancers in Order to Validate the Interest of Innovative Therapies and the Search for Predictive Biomarkers of Response to Treatment
Status: RECRUITING
Conditions: Triple Negative Breast Cancer|Organoid
Interventions: OTHER: Establishment of ex vivo breast cancer organoid models
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: BBI608 and Best Supportive Care vs Placebo and Best Supportive Care in Pretreated Advanced Colorectal Carcinoma
Status: COMPLETED
Conditions: Colorectal Carcinoma
Interventions: DRUG: BBI608|DRUG: Placebo|OTHER: Best Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty
Status: RECRUITING
Conditions: Osteoporosis|Arthroplasty Complications|Fragility Fracture
Interventions: COMBINATION_PRODUCT: Surgeon-Initiated Bone Health Referral Pathway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: DuoStim in Cases of PGT: Comparison of Embryo Quantity and Embryonic Quality Using MitoScore
Status: COMPLETED
Conditions: Infertility, Female
Interventions: DRUG: human menopausal gonadotropin|DRUG: GnRH antagonist|DRUG: GnRH analog|PROCEDURE: Trophectoderm biopsy|DIAGNOSTIC_TEST: MitoScore|PROCEDURE: Intracytoplasmic sperm injection|PROCEDURE: Ovarian puncture|DIAGNOSTIC_TEST: Preimplantation genetic test|PROCEDURE: Embryo transfer|DIAGNOSTIC_TEST: Pregnancy test|PROCEDURE: Embryo freezing|PROCEDURE: Embryo thawing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles
Status: RECRUITING
Conditions: Collagen Degeneration|Wrinkle|Pigmentation|Elastic Skin|Sebum Deficiency
Interventions: OTHER: Topical Product: Almond Oil|OTHER: Topical Product: Almond oil augmented with 0.5% Vitamin E|OTHER: Topical Product: 0.025% Tretinoin oil augmented with castor oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electronic Monitoring Device of Patient-Reported Outcomes and Function in Improving Patient-Centered Care in Patients With Gastrointestinal Cancer Undergoing Surgery
Status: COMPLETED
Conditions: Stage I Adult Liver Cancer|Stage I Colorectal Cancer|Stage IA Gastric Cancer|Stage IA Pancreatic Cancer|Stage IB Gastric Cancer|Stage IB Pancreatic Cancer|Stage II Adult Liver Cancer|Stage IIA Colorectal Cancer|Stage IIA Gastric Cancer|Stage IIA Pancreatic Cancer|Stage IIB Colorectal Cancer|Stage IIB Gastric Cancer|Stage IIB Pancreatic Cancer|Stage IIC Colorectal Cancer|Stage III Pancreatic Cancer|Stage IIIA Adult Liver Cancer|Stage IIIA Colorectal Cancer|Stage IIIA Gastric Cancer|Stage IIIB Adult Liver Cancer|Stage IIIB Colorectal Cancer|Stage IIIB Gastric Cancer|Stage IIIC Adult Liver Cancer|Stage IIIC Colorectal Cancer|Stage IIIC Gastric Cancer|Stage IV Gastric Cancer|Stage IVA Colorectal Cancer|Stage IVA Liver Cancer|Stage IVA Pancreatic Cancer|Stage IVB Colorectal Cancer|Stage IVB Liver Cancer|Stage IVB Pancreatic Cancer
Interventions: OTHER: Computer-Assisted Intervention|DEVICE: Vivofit watch|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Treatment of Deficient Subclass or Anti-polysaccharide Antibody Response
Status: COMPLETED
Conditions: IgG Deficiency|Infections
Interventions: DRUG: intravenous immunoglobulins|DRUG: antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Vagus Nerve Stimulation on Sportive Performance.
Status: COMPLETED
Conditions: Sports Performance
Interventions: DEVICE: Auricular vagus nerve stimulation|DEVICE: Sham Auricular Vagus Nerve Stimulation (AVNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pertuzumab and Cetuximab in Treating Patients With Previously Treated Locally Advanced or Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Colon|Adenocarcinoma of the Rectum|Recurrent Colon Cancer|Recurrent Rectal Cancer|Stage III Colon Cancer|Stage III Rectal Cancer|Stage IV Colon Cancer|Stage IV Rectal Cancer
Interventions: BIOLOGICAL: pertuzumab|BIOLOGICAL: cetuximab|DRUG: irinotecan hydrochloride|OTHER: immunohistochemistry staining method|OTHER: fluorescence in situ hybridization|OTHER: gene expression analysis|OTHER: mutation analysis|OTHER: polymerase chain reaction|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pelvic IMRT With Tomotherapy in Post-Hysterectomy Endometrial Cancer Patients
Status: COMPLETED
Conditions: Endometrial Cancer
Interventions: RADIATION: IMRT|RADIATION: Intracavitary vaginal brachytherapy|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Triamcinolone as Adjunctive Treatment to Laser Panretinal Photocoagulation for Proliferative Diabetic Retinopathy
Status: COMPLETED
Conditions: Diabetic Retinopathy
Interventions: DRUG: Triamcinolone Acetonide 4 mg intravitreal injection|PROCEDURE: Panretinal photocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Liraglutide in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Liraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Cooperative Learning Based Simulation Practice on Sustainability in Care
Status: COMPLETED
Conditions: Nursing Education Research|Nursing Students
Interventions: OTHER: Sustainability education in nursing to be given with two different teaching methods
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Oral Melatonin in Critically Ill High-risk Patients
Status: COMPLETED
Conditions: Critically Ill Patients|Mechanically Ventilated Patients
Interventions: DRUG: Oral melatonin 3mg BID|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Phage Kinetics, and Efficacy of Inhaled AP-PA02 in Subjects With Non-Cystic Fibrosis Bronchiectasis and Chronic Pulmonary Pseudomonas Aeruginosa Infection
Status: COMPLETED
Conditions: Non-cystic Fibrosis Bronchiectasis|Pseudomonas Aeruginosa|Lung Infection
Interventions: BIOLOGICAL: AP-PA02|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nutritional Support for HIV-Tuberculosis Co-infected Adults in Senegal, West Africa
Status: COMPLETED
Conditions: HIV and Tuberculosis Co-infection
Interventions: DIETARY_SUPPLEMENT: Food basket|DIETARY_SUPPLEMENT: Ready-to-Use Therapeutic Food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bilateral vs Unilateral Totally Extraperitoneal Repair Among Patients With Unilateral Inguinal Hernia
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: PROCEDURE: Totally Extra Peritoneal repair (TEP) repair
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strategies to Reduce Weight Gain in Hypertensive Smokers
Status: COMPLETED
Conditions: Cardiovascular Diseases|Heart Diseases|Hypertension|Obesity
Interventions: BEHAVIORAL: Weight Reducing Diet|BEHAVIORAL: Exercise|BEHAVIORAL: Smoking Cessation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety and Efficacy of Tapinarof in Adults With Palmoplantar Keratoderma
Status: RECRUITING
Conditions: Palmoplantar Keratoderma
Interventions: DRUG: Tapinarof
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine and Nab-paclitaxel Combined With Momelotinib in Participants With Previously Untreated Metastatic Pancreatic Ductal Adenocarcinoma
Status: TERMINATED
Conditions: Metastatic Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: Momelotinib|DRUG: Placebo to match momelotinib|DRUG: Nab-paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Safety, Feasibility and Neural Activation of Non-Invasive Light Therapy System
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: OTHER: Light Therapy System (LTS): Active setting|OTHER: Light Therapy System (LTS): Sham setting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Low Doses of Hypoxia-inducible Factor- Prolyl Hydroxylase Enzyme Inhibitor Plus Iron in the Treatment of Anemia in Dialysis-dependent Chronic Kidney Disease Patients
Status: RECRUITING
Conditions: Anemia in Dialysis-dependent CKD Patients
Interventions: DRUG: Roxadustat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Pressure Sores in the Prone Position in ARDS Patients
Status: COMPLETED
Conditions: Pressure Sores
Interventions: PROCEDURE: standard preventive methods of pressure sores|PROCEDURE: experimental multifaceted preventive methods of pressure sores
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Chinese Pediatric Massage on Children With Acute Diarrhea: a Randomized Sham Massage Controlled Trial
Status: COMPLETED
Conditions: Diarrhea
Interventions: OTHER: Chinese pediatric massage therapy + usual care|OTHER: Sham massage therapy + usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: a Trial of Using SMS Reminder Among Diabetic Retinopathy Patients in Rural China
Status: COMPLETED
Conditions: Compliance|Diabetic Retinopathy|SMS
Interventions: OTHER: the SMS reminder message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH