pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of PEEP on Heart and Lungs in Obese Subjects
Status: UNKNOWN
Conditions: Obesity|Pulmonary Atelectasis|Obesity Hypoventilation Syndrome|Magnetic Resonance Imaging|Respiratory Mechanics|Electrical Impedance Tomography|Trans-Thoracic Echocardiography
Interventions: PROCEDURE: Non-Invasive Ventilation|PROCEDURE: Esophageal catheter positioning
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Intravenous Belimumab Versus Placebo in Subjects With Idiopathic Membranous Nephropathy
Status: WITHDRAWN
Conditions: Glomerulonephritis, Membranous
Interventions: DRUG: Belimumab 10 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing BodyWorks: A Canine Health Literacy Module
Status: ACTIVE_NOT_RECRUITING
Conditions: Overweight and Obesity|Overweight Adolescents
Interventions: BEHAVIORAL: BodyWorks Intervention|BEHAVIORAL: Canine Curriculum|BEHAVIORAL: Ecological Momentary Assessment|BEHAVIORAL: Physical Activity Trackers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Dose Finding Study to Assess the Effect of LIK066 Compared to Placebo or Empagliflozin in Patients With Type 2 Diabetes Mellitus and Heart Failure
Status: TERMINATED
Conditions: Diabetes Mellitus and Heart Failure
Interventions: DRUG: LIK066|DRUG: Placebo|DRUG: Empagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib and Gemcitabine in Treating Patients With Metastatic Breast Cancer Previously Treated With An Anthracycline and/or a Taxane
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: erlotinib hydrochloride|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on the Safety and Effectiveness of L-756423 Plus Indinavir in HIV-Positive Patients Who Have Previously Taken Indinavir
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: L-756423|DRUG: Indinavir sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Multi-functional Neuroprosthetic System for Restoration of Motor Function in Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries|Spinal Cord Injury at C5-C7 Level|Spinal Cord Injury Cervical|Spinal Cord Injury at C5-C7 Level With Complete Lesion|Spinal Cord Injury at C5-C7 Level With Incomplete Lesion
Interventions: DEVICE: Networked Neuroprosthetic System for Grasp and Trunk
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serial Use of Intravenous and Oral Tranexamic Acid in Primary Total Knee Arthroplasty Patients
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DRUG: Tranexamic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AutoVPAP Versus VPAP; Assessment of Sleep and Ventilation
Status: COMPLETED
Conditions: Chest Wall Disorder|Neuromuscular Disease
Interventions: DEVICE: VPAP non-invasive ventilator|DEVICE: AutoVPAP non-invasive ventilator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Value of LNG-IUS as Fertility-preserving Treatment of EAH and EC
Status: RECRUITING
Conditions: Endometrial Cancer|Atypical Endometrial Hyperplasia
Interventions: DRUG: Progesterone|DEVICE: Mirena®|DRUG: GnRH agonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venetoclax and Azacitidine for the Treatment of High-Risk Recurrent or Refractory Myelodysplastic Syndrome
Status: RECRUITING
Conditions: Chronic Myelomonocytic Leukemia|Myelodysplastic Syndrome|Recurrent Myelodysplastic Syndrome|Refractory Myelodysplastic Syndrome|Therapy-Related Myelodysplastic Syndrome
Interventions: DRUG: Azacitidine|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Indirect Pulp Capping Versus Pulpotomy With MTA for Treatment of Primary Molars With Deep Caries
Status: UNKNOWN
Conditions: Indirect Pulp Capping|Pulpotomy
Interventions: COMBINATION_PRODUCT: MTA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peer Wellness Enhancement For Patients With Serious Mental Illness and High Medical Costs
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Medical Condition
Interventions: BEHAVIORAL: WE Harambee|BEHAVIORAL: Behavioral Health Home Enrollment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Impact of SNAP-Ed Among Bhutanese Adults Residing in New Hampshire
Status: COMPLETED
Conditions: Supplemental Nutrition Assistance Program Education|Bhutanese Refugee Adults
Interventions: BEHAVIORAL: Direct SNAP-Ed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Acupuncture for Chemotherapy-induced Peripheral Neuropathy
Status: UNKNOWN
Conditions: Peripheral Neuropathy|Toxicity Due to Chemotherapy|Lymphoma|Multiple Myeloma
Interventions: PROCEDURE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ertapenem Pharmacokinetics in Patients in Continuous Ambulatory Peritoneal Dialysis
Status: COMPLETED
Conditions: Continuous Ambulatory Peritoneal Dialysis|End Stage Renal Disease
Interventions: DRUG: ertapenem
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: System for Measuring Non-invasive Blood Flow in the Tracheobronchial Mucosa: Validation of Reproducibility
Status: WITHDRAWN
Conditions: Healthy
Interventions: BIOLOGICAL: Blood flow to the tracheo-bronchial mucosa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neuromodulation and Posterior Tibial Nerve , Randomized Controlled Trial
Status: RECRUITING
Conditions: Pain, Chronic
Interventions: OTHER: transcutaneous pulsed radiofrequency|OTHER: extracorporeal shock wave therapy (ESWT)'
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Nursing C-Spine (Phase IV)
Status: COMPLETED
Conditions: Fracture of Cervical Spine|Fracture Dislocation of Cervical Spine
Interventions: OTHER: Clinical decision rule - clearing the c-spine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-Strain Probiotic Reduces the Frequency of Diarrhea in IBS-D Patients
Status: COMPLETED
Conditions: IBS - Irritable Bowel Syndrome|Diarrhea
Interventions: DIETARY_SUPPLEMENT: QiMeiYan Probiotics|DIETARY_SUPPLEMENT: Placebo product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Olfactory and Gustatory Stimulus on the Nutrition of Premature Babies
Status: ACTIVE_NOT_RECRUITING
Conditions: Weight, Birth|Premature Birth
Interventions: OTHER: Milk|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Assess Efficacy of an Experimental Oral Rinse in Providing Long Term Relief From Dentinal Hypersensitivity
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: DEVICE: Potassium oxalate|DRUG: Sodium fluoride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Single and Multiple Ascending Dose Study of ANX009 in Normal Healthy Volunteers (NHV)
Status: COMPLETED
Conditions: Safety and Tolerability in Healthy Volunteers
Interventions: DRUG: ANX009|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Hydrogen-rich Water on Premenstrual Symptoms and Quality of Life
Status: COMPLETED
Conditions: Premenstrual Syndrome
Interventions: OTHER: Hydrogenated water consumption|OTHER: Drinking water consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Effectiveness and Impact of Community Case Management of Severe Acute Malnutrition
Status: COMPLETED
Conditions: Severe Malnutrition
Interventions: DIETARY_SUPPLEMENT: Management of SAM at home|DIETARY_SUPPLEMENT: Management of SAM at facility
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mitochondrial Diseases - Long-read Genome and Transcriptome Sequencing in Cases Unresolved After Short-read Genomics
Status: RECRUITING
Conditions: Rare Diseases|Genetic Predisposition
Interventions: GENETIC: Next Generation Sequencing (NGS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: SMR Stemless Shoulder Arthroplasty Clinical Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Osteoarthritis|Secondary Osteoarthritis|Post-traumatic; Arthrosis|Rheumatoid Arthritis|Avascular Necrosis of the Head of Humerus|Rotator Cuff Tear Arthropathy
Interventions: DEVICE: SMR Stemless
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective, RCT of Split Thickness Skin Grafts on Lower Leg After Compression Therapy With Compression Bandage vs. NPWT
Status: UNKNOWN
Conditions: Skin Cancer
Interventions: DEVICE: PICO|OTHER: Coban 2 lite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Quality of Care in the Emergency Department by Studying the Appropriateness of Admissions of Patients Accessing the Emergency Department (Fondazione IRCCS Ca' Granda Ospedale Maggione Policlinico)
Status: ACTIVE_NOT_RECRUITING
Conditions: Quality of Care|Evaluation|Emergency Department|Appropriateness
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adult Trauma Centers RE-AIM at Gun Safety (ACTFAST) Prevention
Status: NOT_YET_RECRUITING
Conditions: Firearm Injury|Safety Issues
Interventions: BEHAVIORAL: Adopting Comprehensive Training for FireArm Safety in Trauma Centers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: WTX212A Monotherapy and in Combination With PD -1/PD-L1 Monoclonal Antibody
Status: RECRUITING
Conditions: Advanced Lung Cancer
Interventions: DRUG: WTX212A injection|DRUG: PD -1/PD-L1 monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Oligofructose Supplementation on Body Weight in Overweight and Obese Children
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Oligofructose|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection
Status: ENROLLING_BY_INVITATION
Conditions: Post-Acute COVID-19|Post COVID-19 Condition|Post Viral Fatigue|Dyspnea
Interventions: DIAGNOSTIC_TEST: Computed Tomography of the Chest
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fiber and Metformin Combination Therapy in Adolescents With Severe Obesity and Insulin Resistance
Status: RECRUITING
Conditions: Obesity, Childhood|Insulin Resistance
Interventions: DRUG: Metformin 850 mg oral tablet bid|DIETARY_SUPPLEMENT: Supplemental fiber mixture (35 g total) composed of 6g of Oligofructose + 12g of resistant maltodextrin + 12g of acacia gum + 5g of PGX.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Pre-Treatment With Cromolyn or Albuterol on Response to PUL-042 Inhalation Solution (PUL-042)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PUL-042 Inhalation Solution|DRUG: Cromolyn Sodium|DRUG: Albuterol sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for the Treatment of Phantom Limb and Residual Limb Pain After Amputation
Status: UNKNOWN
Conditions: Phantom Limb|Residual Limb Pain|Traumatic Amputation|Amputation
Interventions: PROCEDURE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coaching Dementia Caregivers to Master Care-Resistant Behavior
Status: RECRUITING
Conditions: Care-resistant Behavior|Dementia
Interventions: BEHAVIORAL: CuRB-IT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immune Molecular and Inflammatory Cytokines Dysfunction Analysis in Gout Patients With Different Urate Levels
Status: COMPLETED
Conditions: Primary Gout
Interventions: DRUG: Diacerein|DRUG: Colchicine|DRUG: Febuxostat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Duration of Pain Relief in Transforaminal and Lumbar Sympathetic Blocks
Status: RECRUITING
Conditions: Low Back Pain|Lumbar Disc Herniation
Interventions: PROCEDURE: Transforaminal steroid injection combined with lumbar sympathetic blockade|PROCEDURE: Transforaminal steroid injection only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes of Inflammatory Cytokines in the Tears of Moderate and Severe MGD Treated With Topical Loteprednol Etabonate
Status: COMPLETED
Conditions: Moderate and Severe Meibomiang Gland Dysfunction (Stage 3 or Stage 4 Meibomiang Gland Dysfunction)
Interventions: DRUG: topical loteprednol etabonate (lotemax 0.5%) with warm compress & ocular massage|OTHER: warm compress only group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sitagliptin (MK-0431) vs. Placebo in Patients With Inadequate Glycemic Control on Metformin With Pioglitazone (MK-0431-128)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin|DRUG: Comparator: Placebo|DRUG: Pioglitazone|DRUG: Metformin|DRUG: Glipizide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MSSA and MRSA Screening in Patients Undergoing Elective TJA: the Benefits of Next-generation Sequencing
Status: UNKNOWN
Conditions: Staphylococcus Aureus|Next Generation Sequencing|Total Joint Arthroplasty
Interventions: DIAGNOSTIC_TEST: next generation sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Stress on Team Coordination and Performance
Status: NOT_YET_RECRUITING
Conditions: Stress Reaction|Stress, Psychological|Stress, Physiological
Interventions: BEHAVIORAL: Psychological stressors added to simulated clinical scenarios.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Switch or Sequential Combination Therapy of Peginterferon in Hepatitis B Patients With Longterm Entecavir Therapy
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: Pegylated interferon alfa-2a|DRUG: Pegylated interferon alfa-2a plus Entecavir|DRUG: Entecavir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Can Steerable Capsule Endoscopy Enhance Gastric Emptying?
Status: COMPLETED
Conditions: Patients Attending Hospital for Small Bowel Endoscopy
Interventions: DEVICE: Wireless Capsule Endoscopy|DEVICE: Magnetically steerable capsule endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Assess the EffectiVeness of exIsting Anti-vascular Endothelial groWth Factor (Anti-VEGF) Treatment Regimens in Patients With Wet Age-related Macular Degeneration
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: Ranibizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating the Safety and Protective Efficacy of a Single Dose of a Trivalent Live Attenuated Dengue Vaccine to Protect Against Infection With DENV-2
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: Recombinant live attenuated trivalent dengue vaccine|BIOLOGICAL: Placebo|BIOLOGICAL: rDEN2Δ30-7169 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Statin Therapy on Sepsis-related Mortality in Intensive Care Unit Patients
Status: COMPLETED
Conditions: Sepsis|Septic Shock
Interventions: OTHER: Person-level linkage of the database looking for relationship with sepsis survival and previous intake of certain drug families and previous dependence on health services.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open-Label Extension of the Dose Finding Study (DSC/08/2357/36) in Patients With Poly Juvenile Idiopathic Arthritis
Status: TERMINATED
Conditions: Juvenile Idiopathic Arthritis
Interventions: DRUG: Givinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intermittent and Continuous Theta Burst Stimulation on Sleep, Daytime Sleepiness, and Fatigue in Depression
Status: NOT_YET_RECRUITING
Conditions: Unipolar Depression|Bipolar Disorder
Interventions: DEVICE: iTBS|DEVICE: cTBS|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perinatal Outcomes Following Change in Clinical Criteria in for Treatment of Maternal Hypertension
Status: RECRUITING
Conditions: Maternal Hypertension
Interventions: PROCEDURE: Clinical blood pressure threshold of SBP >= 160 mmHg for acute treatment of hypertension|PROCEDURE: Clinical blood pressure threshold of SBP >= 180 mmHg for acute treatment of hypertension
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacogenomics of Anti-platelet Intervention-2 (PAPI-2) Study
Status: TERMINATED
Conditions: Cardiovascular Diseases|Acute Coronary Syndrome
Interventions: DRUG: clopidogrel|DRUG: prasugrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Intervention to Promote Smoking Cessation Among Adults With Food Insecurity
Status: COMPLETED
Conditions: Smoking Cessation|Food Insecurity
Interventions: BEHAVIORAL: Food Assistance and Cessation Resources Navigation Plus Economic Assistance|BEHAVIORAL: Food Assistance and Cessation Resources Navigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pegfilgrastim-gema Compared to Pegfilgrastim-roche for Prevention of Induced Neutropenia in Breast Cancer Patients.
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Peg-Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Carboplatin, Pemetrexed Disodium, and Bevacizumab in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: carboplatin|DRUG: pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuragen for Peripheral Diabetic Neuropathy
Status: WITHDRAWN
Conditions: Diabetic Peripheral Neuropathy|Diabetic Neuralgia
Interventions: OTHER: Neuragen|OTHER: Mineral oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Drug-drug Interaction Study of Oral 1250 mg of Vatalinib Administered Under Fasting and Fed Conditions With a Proton-pump Inhibitor in Healthy Sterile or Postmenopausal Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Vatalinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of a Patient Education/Messaging Platform to Increase Uptake and Series Completion of the HPV Vaccine
Status: COMPLETED
Conditions: Human Papilloma Virus Infection Type 11|Human Papilloma Virus Infection Type 16|Human Papilloma Virus Infection Type 18|Human Papilloma Virus Infection Type 6|Cervical Cancer
Interventions: OTHER: THEO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Pilot Study to Evaluate the Systemic Effect of Oral Supplementation With AM3 in Patients With Metabolic Syndrome.
Status: RECRUITING
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: AM3 + Probiotic|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: AM3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Covered Versus Uncovered SEMS for Palliation of Malignant Biliary Strictures.
Status: COMPLETED
Conditions: Biliary Cancer
Interventions: DEVICE: Niti-S Biliary ComVi Stent|DEVICE: Niti-S stent (D type)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: HOPE to Reduce Tumour Recurrence After LT In Patients With HCC
Status: NOT_YET_RECRUITING
Conditions: Liver Cancer|Tumor Recurrence|Hepatocellular Carcinoma|Liver Transplantation|Ex-vivo Hypothermic Perfusion
Interventions: DEVICE: Hypothermic oxygenated Perfusion - HOPE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of COVID-19 Complications in High-risk Subjects Infected by SARS-CoV-2 and Eligible for Treatment Under a Cohort ATU ('Autorisation Temporaire d'Utilisation') OR or Authorisation for Early Access (AAP). A Prospectvie Cohort.
Status: UNKNOWN
Conditions: SARS-CoV Infection|Covid19
Interventions: OTHER: biobank
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation Following Cataract Surgery
Status: TERMINATED
Conditions: Inflammation|Pain|Cataract
Interventions: DRUG: Mapracorat|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab With Gemcitabine and Cisplatin for the Treatment of High-Risk Resectable Liver Cancer Before Surgery
Status: RECRUITING
Conditions: Resectable Intrahepatic Cholangiocarcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Cisplatin|PROCEDURE: Computed Tomography|BIOLOGICAL: Durvalumab|DRUG: Gemcitabine|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cone Beam CT Versus Multislice CT in the Postoperative Assessment of Cochlear Implantation
Status: COMPLETED
Conditions: Cochlear Implants
Interventions: RADIATION: Cone Beam Computed Tomography (CBCT)|RADIATION: Multiple Detector Computed Tomography (MDCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Trial of Rapid Progressive Central Precocious Puberty With Integrative Chinese and Western Medicine
Status: COMPLETED
Conditions: Idiopathic Precocious Puberty
Interventions: DRUG: Ziyinxiehuo Granules Herbs|DRUG: Megestrol Acetate Tablet|DRUG: Leuprorelin Acetate 3.75mg Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Potassium Nitrate Solution in Reducing Dentinal Hypersensitivity
Status: COMPLETED
Conditions: Dentine Hypersensitivity
Interventions: DRUG: 5% Potassium nitrate|DRUG: 2.5% Potassium nitrate|OTHER: Sterile water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Bevacizumab Versus Bevacizumab Plus TPI 287 for Recurrent Glioblastoma
Status: TERMINATED
Conditions: Brain Neoplasms|Central Nervous System Neoplasms
Interventions: DRUG: TPI287|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S-1/Leucovorin (SL) Versus sLV5FU2 as the First-line Treatment for Elderly Patients With Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: S-1, Leucovorin|DRUG: leucovorin, 5-fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of INV-102 Ophthalmic Solution in Adults With Moderate Symptomatic Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: INV-102|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety of the Medical Device Simeox®
Status: TERMINATED
Conditions: Broncho-degenerative Disease|Chronic Obstructive Airway Disease|Cystic Fibrosis|Idiopathic Bronchiectasis|Ciliary Dyskinesia|Chronic Bronchitis
Interventions: DEVICE: Simeox|PROCEDURE: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-Port Transvesical Partial Prostatectomy Versus High Intensity Focused Ultrasound
Status: RECRUITING
Conditions: Prostate Adenocarcinoma|Prostate Cancer
Interventions: PROCEDURE: Transvesical Single Port Robotic Partial Prostatectomy|PROCEDURE: High-intensity focused ultrasound (HIFU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Intrathecal Dexmedetomidine Versus Fentanyl as Adjuvants to Bupivacaine on Post-operative Urinary Retention in Knee Joint Arthroscopic Surgeries
Status: COMPLETED
Conditions: Post-Op Complication
Interventions: DRUG: hyperbaric bupivacaine and dexmedetomidine|DRUG: Bupivacaine-Fentanyl group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Adjuvant Sintilimab for Locally Advanced Esophageal Squamous Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality and Neuropsychiatric Rehabilitation in Patients With Global Developmental Delay.
Status: RECRUITING
Conditions: Global Developmental Delay
Interventions: BEHAVIORAL: TAU + BTsN session|BEHAVIORAL: TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CTA-MCI: Cognitive Control Training in Patients With Amnestic Mild Cognitive Impairment(CTA-MCI)
Status: UNKNOWN
Conditions: Amnestic Mild Cognitive Impairment
Interventions: BEHAVIORAL: internet-based adaptive cognitive control training program|BEHAVIORAL: placebo program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determining the Optimal Dose of AD-209 in Patients With Essential Hypertension
Status: COMPLETED
Conditions: Hypertension,Essential
Interventions: DRUG: AD209|DRUG: Amlodipine low|DRUG: Amlodipine high|DRUG: Telmisartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Baclofen in the Treatment of Alcohol Addiction
Status: COMPLETED
Conditions: Liver Cirrhosis, Alcoholic
Interventions: DRUG: Baclofen|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficiency And Safety Of Association Arbutin, Triamcinolone And Tretinoin In Treatment Of Melasma
Status: SUSPENDED
Conditions: Melasma
Interventions: DRUG: arbutin, tretinoin, triamcinolone|DRUG: Triluma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between Wide and Narrow Fenstrum Endoscopic DCR
Status: UNKNOWN
Conditions: Epiphora|Dacryocystitis|Dacryocystocele
Interventions: PROCEDURE: Endoscopic dacryocystorhinostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Short, Simple, Exercise to Improve Circadian Dependent Postprandial Glycemic Responses
Status: RECRUITING
Conditions: Postprandial Glycemic Response|Postprandial Hyperglycemia|Postprandial Insulin
Interventions: BEHAVIORAL: Stair Stepping|BEHAVIORAL: No exercise control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Longitudinal Antimalarial Combinations in Uganda
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Amodiaquine+Artesunate|DRUG: Amodiaquine+Sulfadoxine/Pyrimethamine|DRUG: Artemether+Lumefantrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Value of Ultra-low Dose Thoracic Scanner for the Pulmonary Arteriovenous Malformation Detection in HHT Patient
Status: COMPLETED
Conditions: Telangiectasia, Hereditary Hemorrhagic|Rendu Osler Disease
Interventions: RADIATION: Low CT scanner without injection dose|RADIATION: Ultra-low dose CT scanner without injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Influence of Manual Therapy Applied to the Cervical Spine in the Prevention of Balance Disorders in the Elderly
Status: UNKNOWN
Conditions: Balance, Postural|Gait|Elderly
Interventions: OTHER: Manual therapy|OTHER: Placebo intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Canagliflozin, 100 mg|DRUG: Metformin XR, 500 mg|DRUG: CANA/MET XR FDC, Formulation 1, 50 mg/500 mg|DRUG: CANA/MET XR FDC, Formulation 2, 50 mg/500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of SPX-101 Inhalation Solution in Subjects With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Placebo Inhalation Solution|DRUG: SPX-101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Show That the Combined Hepatitis A and B Vaccine is Non-inferior to Monovalent Vaccines in Adults
Status: COMPLETED
Conditions: Hepatitis B|Hepatitis A
Interventions: BIOLOGICAL: Twinrix|BIOLOGICAL: Engerix-B|BIOLOGICAL: Havrix|BIOLOGICAL: HBVAXPRO|BIOLOGICAL: Vaqta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study: SONAS Ultrasound for Detecting Stroke SONAS Ultrasound for Detecting Stroke
Status: COMPLETED
Conditions: Stroke, Acute
Interventions: DIAGNOSTIC_TEST: SONAS Ultrasound Device|DRUG: Lumason
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: VE303 for Prevention of Recurrent Clostridioides Difficile Infection
Status: RECRUITING
Conditions: Clostridium Difficile|Clostridium Difficile Infections|Clostridium Difficile Infection Recurrence|Clostridioides Difficile Infection|Clostridioides Difficile Infection Recurrence|CDI|C. Diff Infection|Recurrent Clostridium Difficile Infection|C.Difficile Diarrhea|Diarrhea Infectious
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Solifenacin Succinate Versus Placebo in Inner City Women Ages 20-45 With Overactive Bladder
Status: WITHDRAWN
Conditions: Urinary Urge|Urge Incontinence|Overactive Bladder
Interventions: DRUG: solifenacin succinate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Ondansetron Tablets USP 8 mg Under Fasting Condition
Status: COMPLETED
Conditions: Fasting State
Interventions: DRUG: Ondansetron Tablets USP 8 mg|DRUG: Ondansetron Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomised, Double-blind, Placebo-controlled, Parallel-group Trial to Assess Clinical Efficacy and Safety of NNC0114-0006 in Subjects With Active Crohn's Disease
Status: COMPLETED
Conditions: Inflammation|Crohn's Disease
Interventions: DRUG: NNC0114-0006|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hypersensitivity to CGRP as a Predictive Biomarker of Migraine Prevention With Erenumab
Status: RECRUITING
Conditions: Migraine
Interventions: DRUG: Calcitonin Gene-Related Peptide|DRUG: Erenumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: CPI-613 in Combination With Modified FOLFIRINOX in Patients With Locally Advanced Pancreatic Cancer
Status: WITHDRAWN
Conditions: Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: CPI-613|DRUG: mFOLFIRNOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Nutritional Suitability of a New Infant Formula for Term Infants
Status: COMPLETED
Conditions: Growth
Interventions: OTHER: Investigational infant formula|OTHER: Active Comparator: Commercially available Infant formula|OTHER: Active Comparator: Human milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate Annual Rate of Exacerbations and Safety of 3 Dosage Strengths of Fluticasone Furoate (FF)/GW642444 Inhalation Powder in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: FF/GW642444 Inhalation Powder|DRUG: GW642444 Inhalation Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Doxorubicin Hydrochloride Liposome, Cyclophosphamide, and Trastuzumab in Treating Patients With Stage IV Breast Cancer
Status: COMPLETED
Conditions: HER2-positive Breast Cancer|Male Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: pegylated liposomal doxorubicin hydrochloride|DRUG: cyclophosphamide|BIOLOGICAL: trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Continuous Infusion of Esmolol on Stroke Volume in Patients With Hyperdynamic Vasoplegic Septic Shock
Status: WITHDRAWN
Conditions: Shock, Septic
Interventions: DRUG: Continuous perfusion of esmolol|DRUG: Continuous perfusion of saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influenza A Vaccine (FP-01.1) Formulated With and Without Adjuvant, in the Presence or Absence of a Single Administration of a Trivalent Inactivated Influenza Virus Vaccine in Older Adults
Status: COMPLETED
Conditions: Influenza A
Interventions: BIOLOGICAL: FP-01.1 + Placebo|BIOLOGICAL: FP-01.1 + TIV|BIOLOGICAL: FP-01.1-Adjuvant + Placebo|BIOLOGICAL: FP-01.1-Adjuvant + TIV|BIOLOGICAL: Adjuvant + TIV|BIOLOGICAL: Placebo + TIV|BIOLOGICAL: FP-01.1|BIOLOGICAL: FP-01.1-Adjuvant|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sorafenib Tosylate and Gene Expression Analysis in Patients Undergoing Surgery For High-Risk Localized Prostate Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate|Stage II Prostate Cancer|Stage III Prostate Cancer
Interventions: DRUG: sorafenib tosylate|GENETIC: microarray analysis|OTHER: immunohistochemistry staining method|GENETIC: gene expression analysis|PROCEDURE: needle biopsy|PROCEDURE: therapeutic conventional surgery|OTHER: laboratory biomarker analysis|GENETIC: western blotting|GENETIC: RNA analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Study of 177Lu-NYM032 Injection in mCRPC
Status: RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: 177Lu-NYM032 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Fractional CO2 Laser Therapy On Cancer Survivors With Genitourinary Syndrome Of Menopause (GSM)
Status: RECRUITING
Conditions: Vaginal Atrophy Patients With GSM
Interventions: DEVICE: The FemTouch delivery system|DRUG: Gynomunal gel treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Musculoskeletal Non-tumoral Pathology Quantitative Perfusion
Status: UNKNOWN
Conditions: Osteonecrosis|Pseudarthrosis|Compartment Syndrome
Interventions: OTHER: T1 mapping and MR perfusion acquisition
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intravitreal Adalimumab in Patients With Choroidal Neovascularization Secondary to Age-related Macular Degeneration
Status: COMPLETED
Conditions: Age-Related Macular Degeneration|Choroidal Neovascularization
Interventions: DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Pulmonary Rehabilitation Program on Patients With Acute Ischemic Stroke, Mortality and Disability
Status: UNKNOWN
Conditions: Stroke, Acute|Pulmonary Rehabilitation|Morality
Interventions: OTHER: pulmonary rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Efficacy, Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Participants With Major Depressive Disorder (MDD)
Status: TERMINATED
Conditions: Major Depressive Disorder (MDD)
Interventions: DRUG: Escitalopram|DRUG: Aripiprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MOWOOT Device to Treat Constipation in Adults
Status: COMPLETED
Conditions: Constipation|Constipation; Neurogenic|Constipation Chronic Idiopathic
Interventions: DEVICE: intermittent colonic exo-peristaltic massage treatment with the MOWOOT medical device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Nebivolol on the NO-system in Patients With Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Nebivolol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Seroquel in Bipolar Depression Versus SSRI
Status: COMPLETED
Conditions: Bipolar Disorder|Bipolar Depression|Depression
Interventions: DRUG: quetiapine fumarate (Seroquel)|DRUG: paroxetine|BEHAVIORAL: mood stabilizing activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Pragmatic Trial Examining Oxygenation Prior to Intubation
Status: COMPLETED
Conditions: Acute Respiratory Failure
Interventions: OTHER: Preoxygenation with Non-Invasive Positive Pressure Ventilation|OTHER: Facemask Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Weekly Paclitaxel (BMS-181339)in Patients With Advanced or Recurrent Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of a Multifocal Contact Lens on Symptomatic Patients
Status: COMPLETED
Conditions: Presbyopia
Interventions: DEVICE: etafilcon A multifocal contact lens|DEVICE: etafilcon A Contact Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Radiotherapy in Combination With Zoledronic Acid in Bone Metastasis Patients With Gastrointestinal Tumors
Status: COMPLETED
Conditions: Bone Metastasis|Gastrointestinal Cancer
Interventions: DRUG: Zoledronic acid|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smooth Extubation With Magnesium Sulphate for General Anesthesia With Endotracheal Intubation
Status: COMPLETED
Conditions: Smooth Extubation
Interventions: DRUG: Magnesium sulfate|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Different Insulin Administrations, All in Combination With Metformin, on Glycaemic Control in Subjects With Type 2 Diabetes Inadequately Controlled by Oral Anti-diabetic Drugs
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir|DRUG: insulin aspart|DRUG: biphasic insulin aspart 30|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of HER2 Activation on rhuMAb 2C4 (Pertuzumab) in Subjects With Advanced Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Pertuzumab (rhuMAb 2C4)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-based "STOP (Stop, Take a Breath, Observe, Proceed) Touching Your Face" Intervention
Status: COMPLETED
Conditions: Face-touching Behavior
Interventions: BEHAVIORAL: Mindfulness-based "STOP touching your face" practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT