pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A First In Human Study In Healthy People To Evaluate Safety, Toleration And Time Course Of Plasma Concentration Of Single Inhaled Doses Of PF-05212372.
Status: COMPLETED
Conditions: Phase 1|Single Dose|Safety|Toleration|Pharmacokinetics
Interventions: DRUG: PF-05212372|DRUG: PF-05212372|DRUG: PF-05212372|DRUG: PF-05212372|DRUG: Placebo|DRUG: PF-05212372|DRUG: PF-05212372|DRUG: PF-05212372|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Does Allopurinol Prolong a Treated, Acute Gout Flare?
Status: COMPLETED
Conditions: Gout
Interventions: DRUG: allopurinol|DRUG: Placebo (sugar pill)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Reactogenicity and Immunogenicity of the Pneumococcal Protein PhtD Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Pneumococcal Disease
Interventions: BIOLOGICAL: PhtD vaccine with/without adjuvant|BIOLOGICAL: Pneumovax 23TM|BIOLOGICAL: NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: CyberKnife Accelerated Hemilarynx Stereotactic Radiotherapy Study for Early-stage Glottic Larynx Cancer
Status: COMPLETED
Conditions: Early-stage Glottic Larynx Cancer
Interventions: RADIATION: CyberKnife Accelerated Hemilarynx Stereotactic Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Everolimus and Capecitabine in Patients With Advanced Malignancy
Status: UNKNOWN
Conditions: Advanced Malignancies
Interventions: DRUG: Everolimus|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effect of Instrument Assisted Soft Tissue Mobilization Technique and Foam Roller Application in Individuals With Chronic Non-Specific Neck Pain.
Status: UNKNOWN
Conditions: Instrument-assisted Soft Tissue Mobilization|Flexibility|Foam Roller|Strength|Chronic Non-specific Neck Pain
Interventions: OTHER: Classical Physiotherapy|OTHER: IASTM Technique Application|OTHER: Foam Roller Technique Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Systemic Uptake of Diclofenac Sodium in Combination With Miconazole as Antifungal Nail Gel When Applied Daily With Monitoring of Hepatic and Renal Enzymes, and Serum Levels of Diclofenac 12 Hours After Application, and at 3 and 6 Months Study
Status: UNKNOWN
Conditions: Tinea Unguium, Onychomycosis
Interventions: DRUG: Antifungal Nail Gel Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of EB-001 in Facial Scar Reduction
Status: COMPLETED
Conditions: Mohs Surgery
Interventions: DRUG: EB-001|DRUG: 0.9% Sodium Chloride Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Linifanib (ABT-869) in Combination With Carboplatin/Paclitaxel in Japanese Subjects With Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Linifanib|DRUG: Linifanib|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Establishing Functional Residual Capacity During Newborn Resuscitation on Oxygenation
Status: TERMINATED
Conditions: Resuscitation
Interventions: OTHER: continuous positive airway pressure|OTHER: Free flow oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RADeep Multicenter European Epidemiological Platform for Patients Diagnosed With Rare Anemia Disorders (RADs)
Status: RECRUITING
Conditions: Sickle Cell Disease|Thalassemia|Hemolytic; Anemia, Hereditary, Due to Enzyme Disorder|Anemia Due to Membrane Defect|CDA|Sideroblastic Anemia|Constitutional Aplastic Anemia|Iron Metabolism Disorders|Hereditary Anemia
Interventions: OTHER: Data collection from EHR.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metformin vs Conjugated Linoleic Acid and an Intervention Program With Healthy Habits in Obese Children
Status: UNKNOWN
Conditions: Obesity
Interventions: DRUG: metformin|DIETARY_SUPPLEMENT: Conjugated Linoleic Acid|DRUG: Placebo|BEHAVIORAL: Healthy habits program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Vascular Remodeling Between Different Antianginal Medication Evaluated by Noninvasive ECG-gated Fundus Photographic Evaluation
Status: UNKNOWN
Conditions: Stable Angina
Interventions: DRUG: Diltiazem treated group|DRUG: Bisoprolol treated group|DRUG: Candesartan treated group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: ZF2001 Booster Immunization Clinical Trials of 12 Months After the Completion of Basic Immunization
Status: COMPLETED
Conditions: Prevention of COVID-19
Interventions: BIOLOGICAL: Recombinant novel coronavirus vaccine (CHO cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Cariprazine in the Treatment of Adolescent Participants (13 to 17 Years of Age) With Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: Cariprazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: danceSing Care Evaluation: Testing the Effectiveness
Status: COMPLETED
Conditions: Older Adults|Healthy Aging|Aging|Quality of Life|Depression, Anxiety|Stress, Physiological
Interventions: BEHAVIORAL: danceSing Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cranial Orthosis Therapy for Plagiocephaly: an RCT Pilot Study Comparing Cranial Orthosis to the Natural Course
Status: RECRUITING
Conditions: Plagiocephaly|Plagiocephaly, Nonsynostotic|Plagiocephaly, Positional
Interventions: DEVICE: Cranial Orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinic-based Versus Hotspot-focused Active TB Case Finding
Status: RECRUITING
Conditions: Tuberculosis, Pulmonary|Mycobacterium Tuberculosis Infection
Interventions: OTHER: Active TB case finding with linkage to preventive therapy (ACF/TPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: A Rheumatoid Arthritis Study in Participants on a Background Treatment of Methotrexate
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: LY2127399|DRUG: Placebo Q2W|DRUG: Placebo Q4W|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Amplitude Modulated Radiofrequency Electromagnetic Field Treatment Combined With TAS-102 (Lonsurf) and Bevacizumab in Refractory Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Refractory Metastatic Colorectal Cancer
Interventions: DEVICE: Radiofrequency electromagnetic field treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Define the Electrocardiogram Effects of a Single Dose of LX4211 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LX4211 800 mg|DRUG: LX4211 2000 mg|DRUG: moxifloxacin 400 mg|DRUG: LX4211 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of Regional Anaesthesia for Analgesia After Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Postoperative Pain|Laparoscopic Cholecystectomy|Regional Anesthesia
Interventions: PROCEDURE: M-TAPA block|PROCEDURE: EXORA block|DRUG: Tramadol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modified T-Stenting With Szabo Technique Versus T-Stenting for Bifurcation Lesions in Coronary Heart Diseases
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Szabo T-Stenting Technique|PROCEDURE: T-Stenting Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers
Status: RECRUITING
Conditions: Cancer|Neoplasms|Metastatic Cancer|Triple Negative Breast Cancer|Gastric Cancer|Cervical Cancer|Ovarian Cancer|Hepatocellular Carcinoma|Squamous Cell Carcinoma of Head and Neck|Urothelial Carcinoma|Urothelial Neoplasm|Non Small Cell Lung Cancer|Renal Cell Carcinoma|Locally Advanced Solid Tumor|Locally Advanced Malignant Neoplasm|Squamous Cell Carcinoma|Sarcoma|Merkel Cell Carcinoma|Bladder Cancer
Interventions: DRUG: OC-001|DRUG: Drug: OC-001 in Combination with Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effect of Foam Roller and Kinesiotape Application on Performance Parameters, Pain and Fatigue With Football Players
Status: UNKNOWN
Conditions: Performance|Pain|Fatigue
Interventions: OTHER: Foam roller|OTHER: Kinesiotape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diet Therapy Versus Prescriptive Educational Group Intervention in Overweight / Obese Patients at First Episode of AMI: a Randomized Controlled Trial
Status: UNKNOWN
Conditions: Obesity /Overweight|Acute Myocardial Infarction (STEMI/ NSTEMI)
Interventions: BEHAVIORAL: educational group intervention|BEHAVIORAL: prescriptive diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CellCept (Mycophenolate Mofetil) Combined With Tacrolimus and Corticosteroids in Kidney Transplant Patients.
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: mycophenolate mofetil|DRUG: tacrolimus, standard dose|DRUG: tacrolimus, low dose|DRUG: corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Bencycloquidium Bromide Nasal Spray in the Treatment of Moderate-severe Persistent Allergic Rhinitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Allergic Rhinitis
Interventions: DRUG: Bencycloquidium Bromide Nasal Spray|DRUG: Mometasone Furoate Aqueous Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Oscillatory Positive Expiratory Pressure (oPEP) in Bronchiectasis and COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Bronchiectasis
Interventions: DEVICE: Oscillating Positive Expiratory Pressure (Aerobika ®)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Radiotherapy Compared to Everolimus in Somatostatin Receptor Positive Neuroendocrine Tumors of the Lung and Thymus.
Status: RECRUITING
Conditions: Neuroendocrine Tumors|Lung Neuroendocrine Neoplasm|Thymus Neoplasms
Interventions: DRUG: 177Lu-edotreotide|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ICMNC-HF. IntraCoronary Bone Marrow MonoNuclear Cells in Heart Failure (HF) Patients
Status: UNKNOWN
Conditions: Heart Failure
Interventions: BIOLOGICAL: Intracoronary injection of stem cell|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Cerebral and Peripheral Electrical Stimulation on Conditioned Pain Modulation in Healthy Subjects.
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: PROCEDURE: Transcranial direct current stimulation (tDCS)|PROCEDURE: Peripheral electrical stimulation (PES)|PROCEDURE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Duvelisib to Combat COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Duvelisib|PROCEDURE: Peripheral blood draw|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neo-adjuvant Chemotherapy With Letrozole in Patients With Estrogen Receptor Positive/HER-2 Negative Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer|Invasive Breast Cancer
Interventions: DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Docetaxel|DRUG: Letrozole|DRUG: leuprorelin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Effects of Bolus of Ketamine Versus Fentanyl in Patients With Septic Shock
Status: COMPLETED
Conditions: Ketamine|Fentanyl|Septic Shock
Interventions: DRUG: Ketamine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study on the Effects of Soulera Herbal Blend Intake on Chronic Stress in Healthy Adults
Status: TERMINATED
Conditions: Chronic Stress
Interventions: DIETARY_SUPPLEMENT: Soulera Herbal Blend|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AIM2ACT: A Mobile Health Tool to Help Adolescents Self-Manage Asthma
Status: ACTIVE_NOT_RECRUITING
Conditions: Asthma
Interventions: BEHAVIORAL: AIM2ACT|BEHAVIORAL: mHealth Attention Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Sedation/Cognition/EEG Study Using AZD6280 and Comparator
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: AZD6280|DRUG: AZD6280|DRUG: Lorazepam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cysteinyl Leukotriene Antagonist in Atherosclerosis Inhibition in Patients After Endovascular Treatment Due to Peripheral Arterial Disease
Status: UNKNOWN
Conditions: Peripheral Arterial Disease|Peripheral Vascular Diseases|Lower Limb Ischemia|Atherosclerosis of Artery
Interventions: DRUG: Montelukast 10mg|PROCEDURE: Endovascular treatment|DRUG: Standard anti-platelet treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Phase I/II Study of Lovastatin With High-Dose Cytarabine for Refractory or Relapsed AML
Status: TERMINATED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Cytarabine|DRUG: Lovastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy of Aflibercept for the Treatment of NVCI in Young Patients
Status: COMPLETED
Conditions: Idiopathic Choroidal Neovascularization
Interventions: DRUG: aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Accuracy of the Saranas EBBMS for the Detection of Endovascular Procedure Related Bleeding Events
Status: COMPLETED
Conditions: Endovascular Procedures
Interventions: DEVICE: Saranas Early Bird Bleed Monitoring System (EBBMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Mechanistic Study of the Effects of LY518674 on High-Density Lipoprotein Cholesterol (HDL-C) Metabolism
Status: COMPLETED
Conditions: Metabolic Syndrome X
Interventions: DRUG: LY518674
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of Upper Extremity Rehabilitation Robot and Transcranial Direct Current Stimulation in Subacute Stroke
Status: UNKNOWN
Conditions: Stroke
Interventions: OTHER: Robot and tDCS on-line|OTHER: Robot and sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Non-coding RNAs Analysis of Eosinophil Subtypes in Asthma
Status: UNKNOWN
Conditions: Allergic Asthma|Severe Eosinophilic Asthma
Interventions: BIOLOGICAL: Dermatophagoides pteronyssinus allergen|PROCEDURE: Blood sampling|PROCEDURE: Bronchial challenge with allergen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of the Effects of STN-DBS on Gait in Parkinson's Disease.
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: PROCEDURE: STN-DBS surgery|DEVICE: pulse width|DEVICE: frequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Dydrogesterone Versus GnRH Antagonist in Poor Responders Undergoing Double Ovarian Stimulation
Status: NOT_YET_RECRUITING
Conditions: Infertility
Interventions: DRUG: Progestin primed ovarian stimulation|DRUG: GnRH antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Losartan on Airway Mucociliary Dysfunction in Patients With COPD and Chronic Bronchitis
Status: TERMINATED
Conditions: COPD|Chronic Bronchitis
Interventions: DRUG: Losartan 50 mg|DRUG: Losartan 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Trial of Two Antimalarial Treatments for Clearing Low Density P.Falciparum Parasitaemia in Sudan
Status: COMPLETED
Conditions: Plasmodium Infections
Interventions: DRUG: sulfadoxine-pyrimethamine (SP) plus artesunate (AS)|DRUG: primaquine (PQ) plus SP+AS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of T-CPR on the Quality of CPR and AED Use
Status: COMPLETED
Conditions: Basic Cardiac Life Support|Cardiopulmonary Resuscitation
Interventions: OTHER: T-CPR|OTHER: ERC standardized BLS course
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Radiosurgery Dose Reduction for Brain Metastases on Immunotherapy (RADREMI): A Prospective Pilot Study
Status: COMPLETED
Conditions: Brain Tumor|Brain Metastases|Brain Cancer
Interventions: RADIATION: Reduced Dose SRS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: University of California Health Remote (Home) Monitoring Evaluation
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension
Interventions: BEHAVIORAL: manual monitoring and general education on use|BEHAVIORAL: integrated monitoring and local wrap-around hypertension program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Theophylline, N-acetylcysteine, and Theophylline Plus N-acetylcysteine in Preventing Contrast-induced Nephropathy
Status: UNKNOWN
Conditions: Contrast-Induced Nephropathy
Interventions: DRUG: N-acetylcysteine|DRUG: Theophylline|DRUG: 0.9% sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome
Status: RECRUITING
Conditions: Acute Respiratory Distress Syndrome|Respiratory Failure
Interventions: OTHER: Precision ventilation|OTHER: Guided usual care ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Direct Oral Anticoagulants in Patients With Atrial Fibrillation (DOACs vs Warfarin)
Status: COMPLETED
Conditions: Atrial Fibrillation|Ischemic Stroke|Systemic Embolization|Major Bleed|Myocardial Infarction|All-cause Mortality
Interventions: DRUG: Direct oral anticoagulants (DOACs)|DRUG: Warfarin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CPX-351 in Higher Risk Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: CPX-351 in cohort A|DRUG: CPX-351 in cohort B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cells Treat Liver Cirrhosis
Status: SUSPENDED
Conditions: Liver Cirrhosis
Interventions: DRUG: Conserved Therapy|PROCEDURE: Hepatic artery infusion or Intravenous infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Selective Personalized Radio-Immunotherapy for Locally Advanced NSCLC Trial.
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer, NSCLC
Interventions: DRUG: PembroRT|DRUG: ChemoRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Neurofilament Light (NfL) in Patients With Hydrocephalus
Status: RECRUITING
Conditions: Hydrocephalus|Brain Damage|General Anesthetics Toxicity
Interventions: DIAGNOSTIC_TEST: Lumbar puncture|DIAGNOSTIC_TEST: External lumbar drainage|DIAGNOSTIC_TEST: Lumbar infusion test|PROCEDURE: Ventriculo-peritoneal shunt placement|PROCEDURE: General Anesthesia|PROCEDURE: Prechamber puncture|PROCEDURE: Blood sampling #1|PROCEDURE: Blood sampling #2|PROCEDURE: Blood sampling #3|PROCEDURE: Blood sampling #4 and #5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Family-based Counseling Models for Young Children
Status: COMPLETED
Conditions: Dental Plaque|Dental Caries|Behaviorial Habits
Interventions: BEHAVIORAL: Oral hygiene and fluoride use|BEHAVIORAL: Diet and use of xylitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Caudal Epidural Catheterization in Pediatric Renal Transplant: Effect on Hemodynamics and Pain After Surgery
Status: COMPLETED
Conditions: Renal Failure
Interventions: DEVICE: B-Braun, Perifix® ONE Paed, Germany|DRUG: Pethidine|DRUG: Propofol|DRUG: Bupivacaine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Closed Loop and Education for Hypoglycemia Awareness Restoration
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 1
Interventions: DEVICE: Omnipod 5 or Medtronic 780G|BEHAVIORAL: My HypoCOMPaSS Education|BEHAVIORAL: HARPdoc Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardioprotective Properties of ELAIOTSIPOURA
Status: COMPLETED
Conditions: Cardiometabolic Health
Interventions: BEHAVIORAL: Conventional sea bream|BEHAVIORAL: Enriched sea bream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/3 Clinical Trial to Evaluate the Safety and Efficacy of HUTOX Compared to Botox® in Subjects With Moderate to Severe Crow's Feet Lines
Status: UNKNOWN
Conditions: Crow's Feet Lines
Interventions: BIOLOGICAL: HU-014|BIOLOGICAL: Botox Inj
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Exploration Trial of YOLT-101 in the Treatment of Familial Hypercholesterolemia (FH)
Status: RECRUITING
Conditions: Familial Hypercholesterolemia
Interventions: DRUG: YOLT-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Plamotamab Combined With Tafasitamab Plus Lenalidomide Versus Tafasitamab Plus Lenalidomide in Relapsed or Refractory (R/R) Diffuse Large-cell B-cell Lymphoma (DLBCL)
Status: TERMINATED
Conditions: Diffuse Large-cell B-cell Lymphoma
Interventions: BIOLOGICAL: Plamotamab|BIOLOGICAL: Tafasitamab|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HS-20004 in Healthy Chinese Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HS-20004|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acid Pocket: Position and Aspiration
Status: COMPLETED
Conditions: GERD - PPI Responders|GERD - PPI Non-responders|Barrett Esophagus|Healthy Volunteers
Interventions: DEVICE: multi-pH-impedance manometry catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Arginine as an Adjuvant Treatment Against Tuberculosis
Status: COMPLETED
Conditions: Tuberculosis|HIV
Interventions: DIETARY_SUPPLEMENT: Peanuts|DIETARY_SUPPLEMENT: Daboqolo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetics, Safety and Tolerability of Digoxin With or Without Co-administration of BI 1356 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Digoxin|DRUG: BI 1356
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Trimetazidine on the Improvement of Coronary Microvascular Dysfunction in Patients With INOCA(Ischemia and no Obstructive Coronary Artery Disease)
Status: UNKNOWN
Conditions: Patients With INOCA(Ischemia and no Obstructive Coronary Artery Disease) Who Have Coronary Microvascular Dysfunction
Interventions: DRUG: Trimetazidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Pretreatment With Ticagrelor on Residual Thrombus After PCI in Patients Presenting With ACS in Comparison With Delayed Treatment at the Time of PCI: an OCT Study
Status: WITHDRAWN
Conditions: Acute Coronary Syndrome|Coronary Artery Disease
Interventions: DRUG: Ticagrelor- Delayed Administration|DRUG: Ticagrelor- Immediate Administration|PROCEDURE: Optical Coherence Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Mirena Efficiency and Tolerability During the First Year of Use
Status: COMPLETED
Conditions: Medicated Intrauterine Devices|Contraception
Interventions: DRUG: Mirena (BAY86-5028)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Test Activity of Antimalarial Drugs Against an Induced Malaria Infection in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy|Non-smokers
Interventions: BIOLOGICAL: Blood stage parasite (BSP) inoculum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Surgical Outcomes in Patients With Primary Hyperparathyroidism and Unclear Preoperative Localisation Studies
Status: COMPLETED
Conditions: Primary Hyperparathyroidism
Interventions: PROCEDURE: Parahtyroidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Seasonal Influenza HA DNA With Trivalent Inactivated Vaccine (TIV) Administered ID or IM in Healthy Adults 18-70 Years
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Seasonal Influenza DNA vaccine|BIOLOGICAL: TIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Study to Evaluate the CereVasc® eShunt® System in the Treatment of Communicating Hydrocephalus
Status: TERMINATED
Conditions: Hydrocephalus|Hydrocephalus, Communicating
Interventions: DEVICE: eShunt® Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Two Formulations of Carisoprodol in Subjects With Musculoskeletal Spasm of the Lower Back
Status: COMPLETED
Conditions: Lower Back Pain
Interventions: DRUG: Carisoprodol SR|DRUG: Carisoprodol SR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single-arm Study of Photodynamic Laser Therapy Using Foscan for Non-curatively-resectable Bile Duct Carcinoma
Status: UNKNOWN
Conditions: Non-curative Resectable Bile Duct Carcinoma
Interventions: DRUG: Temoporfin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Gallium-68 HA-DOTATATE PET/CT in Giant Cell Arteritis (GCA)
Status: COMPLETED
Conditions: Giant Cell Arteritis
Interventions: DIAGNOSTIC_TEST: 68-Ga HA-DOTATATE PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Gemcitabine Plus Radiation Therapy or Combination Chemotherapy in Treating Patients With Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: gemcitabine hydrochloride|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind Trial of Antroquinonol in Patients With Chronic Hepatitis B
Status: COMPLETED
Conditions: HBV
Interventions: DRUG: Antroquinonol|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Lonafarnib and Gleevec in Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia
Interventions: DRUG: Lonafarnib (SCH66336)|DRUG: Imatinib Mesylate (Gleevec)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Effectiveness of Increased Standing Time in Non-ambulant Children With Cerebral Palsy:a Pilot Study
Status: COMPLETED
Conditions: Cerebral Palsy|Developmental Delay
Interventions: BEHAVIORAL: Doubling standing time|BEHAVIORAL: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Tooth Whitening on Changes in Quality of Life
Status: COMPLETED
Conditions: Tooth Discoloration|Quality of Life
Interventions: PROCEDURE: whitening photoactivation gel|PROCEDURE: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of a Bioelectric Dressing to Treat Skin Graft Donor Site Wounds
Status: COMPLETED
Conditions: Burns|Wound Healing
Interventions: DEVICE: Procellera (Bioelectric Wound Dressing)|DEVICE: Opsite (Transparent Adhesive Dressing)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Cycling and Sleep in the Pediatric ICU
Status: WITHDRAWN
Conditions: Critical Illness|Sedation Complication|Delirium
Interventions: DRUG: Dexmedetomidine Hydrochloride - Cycling|DRUG: Fentanyl - PICU Standard|DRUG: Dexmedetomidine Hydrochloride - PICU Standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Venlafaxine Hydrochloride Sustained-Release Capsules in Chinese Healthy Volunteers
Status: UNKNOWN
Conditions: Bioequivalence Study
Interventions: DRUG: Venlafaxine Hydrochloride Sustained-Release Capsules 75 mg|DRUG: EFEXOR® XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parental Involvement Improves the Effect of Motivational Interviewing on Weight Loss in Obese Adolescents: A Randomized Controlled Trial Study
Status: COMPLETED
Conditions: Obesity, Adolescent
Interventions: BEHAVIORAL: motivational interviewing|BEHAVIORAL: motivational interviewing with parental involvement|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity of a Subunit Trivalent Nonadjuvated Influenza Study Vaccine in Adults Aged 18 Years and Above
Status: COMPLETED
Conditions: Human Influenza
Interventions: BIOLOGICAL: Trivalent influenza virus vaccine (TIV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Integrated Diagnostics for Early Diagnosis of Liver Disease
Status: RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease|Non-alcoholic Steatohepatitis|Alcoholic Liver Disease|Liver Fibroses
Interventions: OTHER: Blood tests for Single Nucleotide Polymorphisms|DIAGNOSTIC_TEST: Faecal microbiome analysis|DIAGNOSTIC_TEST: Serum for diagnostic biomarkers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of C-CAR088 in Patients With Relapsed or Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: B-cell maturation antigen (BCMA) directed chimeric antigen receptor (CAR)-T cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate Safety & Efficacy of the Combination of Aliskiren, Valsartan & Hydrochlorothiazide in Diabetic Hypertensive Nonresponder Patients
Status: COMPLETED
Conditions: Hypertension|Diabetes
Interventions: DRUG: aliskiren
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Open Label Safety/Efficacy Study of Arhalofenate in Combination With Febuxostat for Hyperuricemia in Gout Patients
Status: COMPLETED
Conditions: Hyperuricemia|Gout
Interventions: DRUG: Arhalofenate|DRUG: Febuxostat|DRUG: Colchicine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diuretic Effect of Metolazone Pre-dosing Versus Concurrent Dosing
Status: TERMINATED
Conditions: Fluid Overload|Heart Failure Acute
Interventions: DRUG: Metolazone 60 minutes prior to furosemide|DRUG: Metolazone concurrently with furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Extended-Release Niacin on Saphenous Vein Graft Atherosclerosis
Status: COMPLETED
Conditions: Aortocoronary Saphenous Vein Bypass Graft Atherosclerosis|Intermediate Saphenous Vein Graft Lesions
Interventions: DRUG: extended-release niacin (Niaspan)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Training & Postural Stability
Status: COMPLETED
Conditions: Postural Stability
Interventions: OTHER: Dynamic neuromuscular stabilisation group|OTHER: Whole body vibration group|OTHER: Dynamic neuromuscular stabilisation with whole body vibration group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Negative Pressure on Pattern Electroretinography Readings
Status: WITHDRAWN
Conditions: Glaucoma|Open Angle, Low Risk|Ocular Hypertension|Glaucoma Suspect
Interventions: DEVICE: Mercury™ Multi-Pressure Dial (MPD) Experimental Goggle|DEVICE: Mercury™ Multi-Pressure Dial (MPD) Placebo Goggle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Exploratory Study to Evaluate Immune Determinants of the Response to Adoptive Cell Therapy (ACT) in Solid and Hematologic Tumors
Status: RECRUITING
Conditions: Solid Tumor, Adult|Solid Tumor, Childhood|Hematologic Cancer
Interventions: PROCEDURE: Tumor biopsy|PROCEDURE: Blood sample|PROCEDURE: Bone marrow sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Quantification of Right Ventricular Function Using Simultaneous Transthoracic and Transoesophageal Echocardiography
Status: WITHDRAWN
Conditions: Cardiac Surgery
Interventions: DIAGNOSTIC_TEST: TTE and TOE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Augmentation of Exposure Using Positive Mental Rehearsal in Individuals With Increased Social Anxiety
Status: RECRUITING
Conditions: Social Anxiety|Social Phobia
Interventions: BEHAVIORAL: Positive Mental Rehearsal|BEHAVIORAL: Mental Rehearsal|BEHAVIORAL: Exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Efficacy of RPH-104 in Preventing Recurrences in Patients With Idiopathic Recurrent Pericarditis
Status: ACTIVE_NOT_RECRUITING
Conditions: Idiopathic Recurrent Pericarditis
Interventions: BIOLOGICAL: RPH-104
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Evaluation After One or Two Doses of Novartis Meningococcal ACWY Conjugate Vaccine in Healthy Infants and Toddlers
Status: COMPLETED
Conditions: Meningococcal Meningitis
Interventions: BIOLOGICAL: MenACWY-CRM197 (two doses)|BIOLOGICAL: MenC|BIOLOGICAL: PCV7|BIOLOGICAL: DTPa-IPV-HepB-Hib|BIOLOGICAL: MenACWY-CRM197 (one dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Transcranial Direct Current Stimulation (tDCS) to Improve Gesture Control
Status: TERMINATED
Conditions: Schizophrenia and Related Disorders
Interventions: DEVICE: left IFG anodal|DEVICE: left IFG cathodal|DEVICE: left IPL anodal|DEVICE: left IPL cathodal|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Frequency Oscillatory Ventilation for Acute Respiratory Distress Syndrome (ARDS)
Status: TERMINATED
Conditions: Acute Respiratory Distress Syndrome
Interventions: DEVICE: Lung protective CMV|DEVICE: HFO-RMs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise in Autoimmune Myasthenia Gravis and Myasthenic Syndromes
Status: COMPLETED
Conditions: Autoimmune Myasthenia Gravis|Lambert-Eaton Myasthenic Syndrome|Congenital Myasthenic Syndrome|Myasthenia Gravis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CA-4948 Added to Standard Chemotherapy to Treat Metastatic or Unresectable Pancreatic Cancer
Status: SUSPENDED
Conditions: Metastatic Pancreatic Ductal Adenocarcinoma|Stage III Pancreatic Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8|Unresectable Pancreatic Ductal Adenocarcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|BIOLOGICAL: Emavusertib|DRUG: Gemcitabine Hydrochloride|PROCEDURE: Magnetic Resonance Imaging|DRUG: Nab-paclitaxel|PROCEDURE: Positron Emission Tomography|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetics of Cannabis Use Disorder and Cannabinoid Response in Humans
Status: NOT_YET_RECRUITING
Conditions: Schizophrenia|Cannabis Use Disorder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Determine Eligibility for CAH-301 (A Study of Gene Therapy for Classic Congenital Adrenal Hyperplasia (CAH) [NCT04783181])
Status: RECRUITING
Conditions: Congenital Adrenal Hyperplasia
Interventions: OTHER: Pre-Screening
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of a Fatty Meal on Endoscopic Retrograde Cholangiopancreatography (ERCP)
Status: COMPLETED
Conditions: Biliary Tract Disease
Interventions: BEHAVIORAL: a fatty meal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Safety and Preliminary Efficacy of Ibrutinib and Pembrolizumab in Patients With Chronic Lymphocytic Leukemia (CLL) or Mantle Cell Lymphoma (MCL)
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Mantle Cell Lymphoma
Interventions: DRUG: Ibrutinib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Ability of a Single Infusion of High-Density Lipoprotein (HDL) to Modulate Markers of Cerebral Ischaemia
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: Reconstituted High Density Lipoprotein|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Preventive Drug-coated Balloon Angioplasty in Vulnerable Atherosclerotic Plaque (RESTORE Trial)
Status: RECRUITING
Conditions: Acute Coronary Syndrome (ACS)
Interventions: DEVICE: Drug-coated balloon|DRUG: Guideline-directed medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Efficacy and Safety of Tozorakimab in Participants With Chronic Obstructive Pulmonary Disease With a History of Exacerbations (PROSPERO).
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: COMBINATION_PRODUCT: Tozorakimab 1|COMBINATION_PRODUCT: Tozorakimab 2|COMBINATION_PRODUCT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mexiletine for Muscle Cramps in Charcot Marie Tooth Disease
Status: COMPLETED
Conditions: Charcot Marie Tooth Disease
Interventions: OTHER: Placebo|DRUG: Mexiletine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D in Preschoolers With Viral-induced Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DIETARY_SUPPLEMENT: vitamin D|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION