pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Use of Rft5-Dga to Deplete Alloreactive Cells for Pts With Fanconi Anemia After Haploidentical SCT
Status: TERMINATED
Conditions: FANCONI ANEMIA
Interventions: PROCEDURE: CD34 selected haploidentical PBSCT|DRUG: Fludarabine|BIOLOGICAL: T cell infusion|BIOLOGICAL: Campath 1h|BIOLOGICAL: anti-CD45
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-PD-1 Antibody With HD IL-2 in Metastatic Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: Pembrolizumab|DRUG: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Peripheral Retinal Changes on Wide Field Angiography in Diabetic Macular Edema
Status: COMPLETED
Conditions: Non-proliferative Diabetic Retinopathy|Proliferative Diabetic Retinopathy|Diabetic Macular Edema
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety, Pharmacokinetic and the Effect of Food After Administration of ABN401 in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Solid Tumor
Interventions: OTHER: High-fat meal (over 900 kcal)|DRUG: ABN401 (investigational product)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Brimonidine Tartrate Nanoemulsion Eye Drops in Patients With Ocular Graft-vs-Host Disease
Status: TERMINATED
Conditions: Graft Versus Host Disease|Ocular Surface Disease|oGVHD|Ocular Graft vs Host Disease|Brimonidine Tartrate|Lubricant Eye Drops|Ophthalmic Solutions|Graft vs Host Disease
Interventions: DRUG: Brimonidine Tartrate|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Study of MAstectomy With Reconstruction Including Robot Endoscopic Surgery
Status: RECRUITING
Conditions: Breast Neoplasms|Germline BRCA1 Gene Mutation|Germline BRCA2 Gene Mutation|Benign Breast Disease|Germline Mutation Abnormality
Interventions: PROCEDURE: Robotic or endoscopic nipple sparing mastectomy|PROCEDURE: Conventional mastectomy (including nipple sparing mastectomy, skin sparing mastectomy)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: BASET Scoring: A Novel Simple Biometric Score and Potential Tool for Diagnosis and Grading of Obstructive Sleep Apnea Syndrome (OSAS) Patients
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DIAGNOSTIC_TEST: BASET score
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Tropical Influenza Control Strategies for the Elderly
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: Influenza vaccine|BIOLOGICAL: Influenza vaccine|BIOLOGICAL: Tetanus-diphtheria-pertussis vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Endothelial Function After Cardiac Surgery
Status: COMPLETED
Conditions: Endothelial Dysfunction
Interventions: DRUG: Human albumin|DRUG: Hydroxyethyl starch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Seal-G MIST (Minimally Invasive Sealant/Spray Technology) System Safety Study [SEALAR Study]
Status: WITHDRAWN
Conditions: Colorectal Cancer|Diverticulitis Colon
Interventions: DEVICE: Seal-G MIST System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dose-Tolerability Titration Study to Evaluate The Efficacy And Safety Of Perampanel (E2007) In Patients With Post-Herpetic Neuralgia (PHN)
Status: COMPLETED
Conditions: Neuralgia
Interventions: DRUG: E2007 (perampanel)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Vorasidenib in Participants With Moderate or Mild Hepatic Impairment and Matched Participants With Normal Hepatic Function
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: Vorasidenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A SAD/MAD Study to Evaluate the Safety, Tolerability, PK of MT200605 in Healthy Subjects
Status: ENROLLING_BY_INVITATION
Conditions: Healthy
Interventions: DRUG: MT200605 for Injection|DRUG: MT200605 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Physiological Assessment of the Endothelium - Circadian Rhythm and Role of the Sympathetic Nervous System
Status: COMPLETED
Conditions: Endothelial Function
Interventions: PROCEDURE: Mental stress|OTHER: no intervention|PROCEDURE: Myogenic activation|PROCEDURE: Cold pressure test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase II Open Label, Non-randomized Study of Sorafenib and Everolimus in Relapsed and Non-resectable Osteosarcoma
Status: COMPLETED
Conditions: Metastatic Osteosarcoma|Relapsed Osteosarcoma
Interventions: DRUG: Sorafenib|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sociodemographic, Clinical, Quality of Life and Health Care Conditions in COVID-19 Survivors.
Status: COMPLETED
Conditions: Post-acute COVID-19 Syndrome|Long-COVID|COVID-19|Long COVID|Post-acute Sequelae of SARS-CoV-2 Infection
Interventions: OTHER: Exposure: Coronavirus disease 2019 (COVID-19)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of a Telephone Based Peer Support to Reduce Depressive Symptoms and Improve Social Support in Women With CHD
Status: COMPLETED
Conditions: Depressive Symptoms|Low Perceived Social Support|Coronary Heart Disease
Interventions: BEHAVIORAL: Telephone based peer support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy Comparison Study of Steroids to Control Post-operative Inflammation
Status: UNKNOWN
Conditions: Inflammation|Intraocular Pressure
Interventions: DRUG: Subtenon 20-mg triamcinolone injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Wearable Technology to Characterize and Treat mTBI Subtypes: Biofeedback-Based Precision Rehabilitation
Status: RECRUITING
Conditions: Mild Traumatic Brain Injury, Concussion|Rehabilitation|Balance Impairment
Interventions: OTHER: Vestibular therapy for mTBI augmented with audio and visual real-time biofeedback|OTHER: Vestibular therapy for mTBI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ACTIV-6: COVID-19 Study of Repurposed Medications - Arm C (Fluticasone)
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Fluticasone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Upregulating the Nitric Oxide Pathway To Restore Autonomic Phenotype (UNTRAP).
Status: COMPLETED
Conditions: Heart Failure|Arrhythmia
Interventions: DIETARY_SUPPLEMENT: Nitrate-rich beetroot juice|DIETARY_SUPPLEMENT: Nitrate-free beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Disturbance of Plasma Cytokine Parameters in Clozapine-Resistant Treatment-Refractory Schizophrenia (CTRS) and Their Association With Combination Therapy
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: sodium valproate with Clozapine|DEVICE: modified electroconvulsive therapy(MECT) with Clozapine|DRUG: amisulpride with Clozapine|DRUG: placebo with Clozapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GeneSearch™ Breast Lymph Node (BLN) Assay China Registration Study
Status: TERMINATED
Conditions: Breast Cancer
Interventions: PROCEDURE: GeneSearch™ Breast Lymph Node (BLN) Assay
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Teachable Moment: Screening and Brief Intervention for Admitted Trauma Patients
Status: COMPLETED
Conditions: Alcoholism
Interventions: BEHAVIORAL: Quantity Frequency Model|BEHAVIORAL: Targets Subjective Drunkenness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Cognitive Behavioral Therapy +/- Armodafinil for Insomnia and Fatigue Following Chemotherapy
Status: COMPLETED
Conditions: Insomnia|Fatigue|Breast Cancer
Interventions: DRUG: armodafinil|DRUG: Placebo Comparator|BEHAVIORAL: CBT-I
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase II Study of Serplulimab Plus Bevacizumab in Combination With Chemotherapy in 1L Treatment of Untreated Recurrent or Metastatic Cervical Cancer
Status: NOT_YET_RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: Serplulimab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microbiota Transplant in Advanced Lung Cancer Treated With Immunotherapy
Status: RECRUITING
Conditions: Lung Cancer
Interventions: DIETARY_SUPPLEMENT: Microbiota Transplant plus anti PD1 therapy|DRUG: anti PD1 therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RIMAG Study: Trial of Rituximab Versus Placebo in Polyneuropathy Associated With Anti-MAG IgM Monoclonal Gammopathy
Status: COMPLETED
Conditions: Polyneuropathy
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety & Efficacy Study of Oral Panobinostat (LBH589) With Chemotherapy in Patients < 65 Years Old With Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: Panobinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Parental Involvement in Exergames Play on Physical and Mental Health on Overweight and Obese Male Adolescent
Status: RECRUITING
Conditions: Physical Inactivity|Overweight and Obesity|Psychosocial Problem
Interventions: DEVICE: cooperative versus competitive AVG play
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gait and Posture Analysis in Hemiparetic Patients Through Optoelectronic Systems, "Smart" Tools and Clinical Evaluation
Status: RECRUITING
Conditions: Stroke Sequelae|Hemiparesis|Gait Disorders, Neurologic
Interventions: DIAGNOSTIC_TEST: Movement analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Research Study to Compare Semaglutide to Insulin Aspart, When Taken Together With Metformin and Insulin Glargine, in People With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide|DRUG: Insulin aspart|DRUG: Insulin glargine U100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HM vs Fibreglass Casts in Treating Pediatric Supracondylar Humeral Fractures
Status: COMPLETED
Conditions: Pediatric Supracondylar Humeral Fracture
Interventions: DEVICE: HM Cast|DEVICE: Fibreglass Cast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men and Women to Test Whether BI 1358894 Influences the Amount of Bupropion in the Blood
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Elontril|DRUG: BI 1358894
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial of Surfactant Therapy For Preterm Neonates 5-21 Days Old With Respiratory Decompensation
Status: COMPLETED
Conditions: Respiratory Distress Syndrome
Interventions: DRUG: Infasurf (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Safety and Efficacy of a Moisturizer Body Lotion and a Lip Moisturizer in Adults of Atopic Dermatitis.
Status: WITHDRAWN
Conditions: Atopic Dermatitis
Interventions: OTHER: Moisturizer Body Lotion|OTHER: Lip Moisturizer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Radiotherapy Plus Sintilimab for HCC With Portal Vein Tumor Thrombosis
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma|Portal Vein Tumor Thrombosis
Interventions: RADIATION: Radiotherapy|DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Ring-based Prevention Trial With Lopinavir/Ritonavir
Status: UNKNOWN
Conditions: Coronavirus Infections|Post-exposure Prophylaxis
Interventions: DRUG: Lopinavir/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Test the Combination of Voriconazole and Anidulafungin in Patients Who Have, or Are Thought to Have, Invasive Aspergillosis and Who Are Unable to Take a Common Antifungal Therapy (Polyene)
Status: TERMINATED
Conditions: Aspergillosis
Interventions: DRUG: voriconazole|DRUG: anidulafungin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dry Needling and Therapeutic Exercise on Sleep in Individuals With Chronic Neck Pain and Sleep Disturbance
Status: ACTIVE_NOT_RECRUITING
Conditions: Neck Pain|Sleep Disturbance
Interventions: PROCEDURE: Dry Needling|OTHER: Therapeutic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Intra-articular Corticosteroid Injection Compared With Single-Shot Hyaluronic Acid for Treatment of Osteoarthritis Knee
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: Hylan G-F 20|DRUG: Corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Safety and Immunogenicity Study of the Epitope Based DNA Vaccine (EP HIV-1090) in HIV-1 Infected Individuals Receiving Antiretroviral Therapy (ART)
Status: UNKNOWN
Conditions: HIV Infections
Interventions: BIOLOGICAL: EP1090|BIOLOGICAL: EP1090
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CLN-0045: Safety, and Efficacy of OTX-TIC in Participants With Open Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Ocular Hypertension|Open Angle Glaucoma
Interventions: DRUG: OTX-TIC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Generic Racecadotril 100 mg Capsules Under Fasting Conditions
Status: NOT_YET_RECRUITING
Conditions: Healthy Vollunteer
Interventions: DRUG: Racecadotril 100 mg Capsules|DRUG: HIDRASEC®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combination Effects of Pregabalin and Dexmedetomidine on Postoperative Pain
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Pregabalin|DRUG: Dexmedetomidine|OTHER: Placebo|DRUG: Pregabalin and dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Pembrolizumab (MK-3475) in Combination With Chemotherapy as Neoadjuvant Treatment for Participants With Triple Negative Breast Cancer (TNBC) (MK-3475-173/KEYNOTE-173)
Status: COMPLETED
Conditions: Triple Negative Breast Neoplasms
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Nab-paclitaxel|DRUG: Anthracycline (doxorubicin)|DRUG: Cyclophosphamide|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Uptake of Medical Male Circumcision Among Men With Sexually Transmitted Infections
Status: COMPLETED
Conditions: HIV Infections|Sexually Transmitted Infections
Interventions: OTHER: Standard of care|BEHAVIORAL: Intensified Health Education|BEHAVIORAL: SMS/telephonic Tracing|BEHAVIORAL: Transportation Reimbursement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Trial of Miltefosine to Treat Mucosal Leishmaniasis
Status: COMPLETED
Conditions: Leishmaniasis|Leishmaniasis, Mucocutaneous
Interventions: DRUG: Miltefosine|DRUG: Standard Treatment Meglumine antimoniate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: INTERconNEcT-Eds: a Guided Self-help Mobile App to Improve Outcome in Eating Disorders
Status: NOT_YET_RECRUITING
Conditions: Eating Disorder Symptom|Eating Disorders|Eating Behavior
Interventions: BEHAVIORAL: Guided self-help plus IPT|BEHAVIORAL: Guided self-help|BEHAVIORAL: TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Anti-IL-20 in Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Inflammation|Rheumatoid Arthritis
Interventions: DRUG: anti-IL-20|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Colonic Carriage of Staphylococcus Aureus in a Prospective Cohort of Patients Undergoing Endoscopic Screening for Digestive Cancer in the University Hospital of Saint-Etienne
Status: COMPLETED
Conditions: STAPHYLOCOCCAL INFECTIONS
Interventions: OTHER: Staphylococcus aureus carriage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: SMART Dressing for Hypertrophic Scar Treatment Post-Total Knee/Hip Arthroplasty
Status: COMPLETED
Conditions: Knee Arthropathy|Hip Arthropathy|Hypertrophic Scar
Interventions: COMBINATION_PRODUCT: Smart Scar Care Pad=Pressure Garment|DEVICE: Pressure Garment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fixed Duration vs Continuous Daratumumab in Transplant Ineligible Older Adults With Newly Diagnosed Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Daratumumab|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Defocus in Soft Contact Lenses on Internal Retinal Vascularization
Status: RECRUITING
Conditions: Nearsightedness
Interventions: DEVICE: Experimental: Myopic defocus soft lens design (MDSL)|DEVICE: Active Comparator: Single vision soft lens design (SVSL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: ¹³C-Methacetin Breath Test (MBT) Methodology Study
Status: UNKNOWN
Conditions: Healthy Subjects|Chronic Liver Disease|Cirrhosis
Interventions: DEVICE: 13C Methacetin Breath Test|DIETARY_SUPPLEMENT: Grape fruit juice|DRUG: Non selective beta blocker - Propranolol|DIETARY_SUPPLEMENT: Ethanol
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: A Multicenter Randomized Controlled Clinical Study on the Treatment of T3N1M0 High Risk Nasopharyngeal Carcinoma With or Without Induction Chemotherapy Before Concurrent Radiotherapy and Chemotherapy
Status: NOT_YET_RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Induction chemotherapy plus Concurrent chemotherapy|DRUG: Concurrent chemotherapy|RADIATION: IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: New Approaches to Nerve Stimulation Therapy for Bladder Pain Syndrome
Status: RECRUITING
Conditions: Bladder Pain Syndrome
Interventions: PROCEDURE: Pulsed radiofrequency ablation|PROCEDURE: Sham ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Very Low Calorie and Low Calorie Diet on Moderate to Severe Obstructive Sleep Apnea in Obese Adults
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: OTHER: Low Calorie Diet|OTHER: Very Low Calorie Diet|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Alemtuzumab to Treat Advanced Mycosis Fungoides/Sezary Syndrome
Status: UNKNOWN
Conditions: Mycosis Fungoides|Sezary Syndrome
Interventions: DRUG: alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Screening for Obstructive Sleep Apnea Among Members of an Internet Weight Loss Community
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: BEHAVIORAL: Obstructive sleep apnea screening intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Clinical Performance of Chairside CAD/CAM Restorations
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Cements|Caries,Dental
Interventions: DEVICE: Lithium disilicate onlays (IPS emaxCAD/Ivoclar)|DEVICE: Chairside zirconia crowns (3M)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 99mTc-MIP-1404 for Imaging Prostate Cancer: Phase I Clinical Study to Assess the Image Quality of a Simplified Kit Formulation Compared to a Multi-step Preparation of 99mTc-MIP-1404
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: 99mTc-MIP-1404
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of SS1(dsFv)-PE38 (SS1P) Anti-Mesothelin Immunotoxin in Advanced Malignancies: Continuous Infusion for 10 Days
Status: WITHDRAWN
Conditions: Neoplasms
Interventions: DRUG: SS1(dsFv)-PE38
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Effect of HIVconsv Vaccines in Combination With Histone Deacetylase Inhibitor Romidepsin on the Viral Rebound Kinetic After Treatment Interruption in Early Treated HIV-1 Infected Individuals
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: MVA.HIVconsv vaccine|DRUG: Romidepsin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Highest Efficacy of Dual Antiplatelet Therapy After Carotid Artery Stenting in High Bleeding Risk Patients
Status: NOT_YET_RECRUITING
Conditions: Carotid Artery Diseases
Interventions: DRUG: Patients who are scheduled to undergo carotid artery stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Serious Illness Treatment Preferences and Outcomes in the Patients Receiving Peritoneal Dialysis
Status: UNKNOWN
Conditions: ESRD|Peritoneal Dialysis
Interventions: BEHAVIORAL: integrated palliative care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study to Assess the Efficacy and Safety of XC221 in Patients With COVID-19
Status: COMPLETED
Conditions: SARS-CoV-2 Infection
Interventions: DRUG: XC221|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Mild Traumatic Brain Injury on Recovery From Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury|Trauma|Head Injury|Brain Concussion
Interventions: PROCEDURE: neuropsychologic testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Online Regional Anesthesia Resources - Are They Effective?
Status: RECRUITING
Conditions: Education
Interventions: OTHER: Self exploring of available online material on supraclavicular brachial plexus block|OTHER: Conventional in-person teaching on supraclavicular brachial plexus block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Subgaleal Drains in Decompressive Craniectomies
Status: COMPLETED
Conditions: Hematoma Intracranial|Hydrocephalus|Surgical Site Infection|Wound Breakdown|Bradycardia|Hypotension Postprocedural
Interventions: PROCEDURE: Passive Redon subgaleal drains|PROCEDURE: Vacuum Redon subgaleal drains|PROCEDURE: No Redon subgaleal drains
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Safety and Efficacy Study of Intravenous (IV) Elezanumab Assessing Change in Neurologic Function in Adult Participants With Acute Ischemic Stroke
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Elezanumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Moderately Fractionated IMRT for Locally Extremity or Trunk Sarcoma
Status: RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: Fluzoparib|RADIATION: Preoperative moderately fractionated radiotherapay
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of STN-DBS for Primary Cranial-Cervical Dystonia
Status: UNKNOWN
Conditions: Dystonia
Interventions: PROCEDURE: Stimulation|PROCEDURE: Sham-stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial Comparing Conventional Laparoscopic and Robot-Assisted Laparoscopic Hysterectomy
Status: COMPLETED
Conditions: Menorrhagia|Pelvic Pain|Hysterectomy
Interventions: PROCEDURE: Hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HYPERTONIC SALINE IN ACUTE VIRAL BRONCHIOLITIS: A RANDOMIZED CLINICAL TRIAL
Status: WITHDRAWN
Conditions: Acute Viral Bronchiolitis.
Interventions: DRUG: normal saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PEACE: Comparing Chronic Pain Treatment Options
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Pain|Musculoskeletal Pain|Fibromyalgia|Pain Management
Interventions: PROCEDURE: Electro-Acupuncture (EA)|PROCEDURE: Battle Field Acupuncture (BFA)|DEVICE: Wait List Control (WLC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment Outcome and Quality of Life in Patients With Pediatric Extra-Cranial Germ Cell Tumors Previously Treated on Clinical Trial CCLG-GC-1979-01 or CCLG-GC-1989-01
Status: UNKNOWN
Conditions: Childhood Germ Cell Tumor|Extragonadal Germ Cell Tumor|Gastrointestinal Complications|Infertility|Long-term Effects Secondary to Cancer Therapy in Children|Neurotoxicity|Ovarian Cancer|Pulmonary Complications|Sexual Dysfunction|Urinary Complications
Interventions: PROCEDURE: assessment of therapy complications|PROCEDURE: quality-of-life assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Two Regimens of Docetaxel in Treating Patients Who Have Not Received Chemotherapy For Unresectable Stage IIIB or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of the Topcon Tonometers CT-800 and TRK-2P and the Haag-Streit Goldmann Manual Tonometer and Topcon SP-1P
Status: COMPLETED
Conditions: Intraocular Pressure
Interventions: DEVICE: Topcon CT-800|DEVICE: Topcon TRK-2P
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of VQm PHM on Pulmonary Health Parameters for ICU
Status: NOT_YET_RECRUITING
Conditions: Ventilators, Mechanical|Stroke|COPD|Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)|Pneumonia
Interventions: DEVICE: VQm Pulmonary Health Monitor™
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mindfulness-Based Stress Reduction With Older Adults Living With Cognitive Impairment in Primary Care.
Status: UNKNOWN
Conditions: Feasibility Randomized Control Trial
Interventions: BEHAVIORAL: Mindfulness-Based Stress Reduction (MBSR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bexarotene Augmentation of Antipsychotic Treatment for Chronic Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Bexarotene (Targretin LGD1069)|DRUG: bexarotene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?
Status: RECRUITING
Conditions: Infertility, Female|Miscarriage|Miscarriage, Recurrent|IVF
Interventions: DIAGNOSTIC_TEST: Transvaginal ultrasound|DIAGNOSTIC_TEST: Blood test AMH
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fibromyalgia Treatment Trial With Gabapentin and Osteopathic Manipulative Medicine
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: Gabapentin|PROCEDURE: Osteopathic Manipulative Medicine|OTHER: Gabapentin and Osteopathic Manipulative Medicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of MB-102 (Relmapirazin) and the Use of the MediBeacon® Transdermal GFR Measurement System Using the TGFR Reusable Sensor With Disposable Adhesive Ring
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Diseases|Kidney Injury|Kidney Failure
Interventions: DRUG: MB-102|DEVICE: MediBeacon Transdermal Glomerular Filtration Rate Measurement System (TGFR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 1/1b Study of Rilotumumab in Japanese Subjects With Advanced Solid Tumors or Advanced or Metastatic Gastric or GEJ
Status: COMPLETED
Conditions: Part 1- Advanced Solid Tumors|Part 2- Advanced or Metastatic Gastric Cancer|Part 2- Advanced or Metastatic GEJ
Interventions: DRUG: Rilotumumab|DRUG: Rilotumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin E for Oxaliplatin-induced Peripheral Neuropathy Prophylaxis
Status: COMPLETED
Conditions: Peripheral Neuropathy
Interventions: DRUG: Vitamin E|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Multicenter Randomized Controlled Study of Non-invasive Brain Oscillation Modulation in the Treatment of AD-MCI Patients
Status: NOT_YET_RECRUITING
Conditions: AD-MCI
Interventions: DEVICE: Transcranial electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 3-Tesla MRI Response to TACE in HCC (Liver Cancer)
Status: TERMINATED
Conditions: Adult Primary Hepatocellular Carcinoma|Advanced Adult Primary Liver Cancer|Localized Resectable Adult Primary Liver Cancer|Localized Unresectable Adult Primary Liver Cancer|Stage A Adult Primary Liver Cancer (BCLC)|Stage B Adult Primary Liver Cancer (BCLC)
Interventions: DEVICE: 3 Tesla Magnetic Resonance Imaging|DRUG: Magnevist® (Intravenous (IV) administration of MRI contrast agent)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ga68-FAPI-46 PET/CT for Preoperative Assessment of Peritoneal Carcinomatosis
Status: RECRUITING
Conditions: Cancer|Peritoneal Carcinomatosis
Interventions: DIAGNOSTIC_TEST: FAPI PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: On-X Heart Valve - 17mm Aortic and 23mm Mitral
Status: TERMINATED
Conditions: Heart Valve Disease
Interventions: DEVICE: 17mm aortic valve (On-X )|DEVICE: 23mm mitral valve (On-X)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Relative Bioavailability and Safety of INL-001 Compared to Marcaine After Open Hernioplasty
Status: COMPLETED
Conditions: Hernioplasty
Interventions: COMBINATION_PRODUCT: INL-001 (bupivacaine HCl collagen implant)|DRUG: Marcaine 0.25% infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Clinical Trial on Safety and Efficacy of Drug-coated Balloon in Treatment of Coronary Bifurcation Lesions
Status: COMPLETED
Conditions: Coronary Disease
Interventions: DEVICE: Paclitaxel DCB|DEVICE: DES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin Treatment in Progressive Multiple Sclerosis
Status: RECRUITING
Conditions: Secondary Progressive Multiple Sclerosis|Primary Progressive Multiple Sclerosis
Interventions: DRUG: Metformin 500 Mg Oral Tablet, up to 4 tablets a day|DRUG: Placebo oral tablet identical to metformin, up to 4 tablets a day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study With Abraxane, Bevacizumab and Carboplatin in Triple Negative Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Abraxane|DRUG: Bevacizumab|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ARTEMIS DIANE T790M (An Amino Acid Substitution at Position 790 in EGFR, From a Threonine (T) to a Methionine (M)) Mutation at Hospital Laboratories in Comparison With Central Laboratory
Status: COMPLETED
Conditions: Locally Advanced or Metastatic EGFR(+) NSCLC Patients
Interventions: PROCEDURE: genomic testing of T790M mutation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pharmacokinetic Study to Access How the Body Absorbs and Removes Linifanib in Male Patients With Advanced Solid Tumors.
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: DRUG: [14C]linifanib|DRUG: ABT-869, linifanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pomalidomide, Dexamethasone and Rituximab in Waldenstrom's Macroglobulinemia
Status: TERMINATED
Conditions: Waldenstrom's Macroglobulinemia
Interventions: DRUG: pomalidomide|DRUG: dexamethasone|DRUG: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of [18]F-PSMA-1007 in Patients With Known or Suspected Metastatic Prostate Cancer
Status: RECRUITING
Conditions: Oncology|Prostate Cancer
Interventions: DRUG: [18]F-PSMA-1007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mepilex Ag Versus Silver Sulfadiazine in Children and Adults With Burn Injuries.
Status: COMPLETED
Conditions: Burn Injuries
Interventions: DEVICE: Mepilex Ag|DRUG: Silver Sulphadiazine Ag cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I, Multicenter, Open-label, Dose-escalating, Clinical and Pharmacokinetic Study of PM01183 in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: ADVANCED SOLID TUMORS
Interventions: DRUG: PM01183
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of RAD301 in Healthy Human Volunteers and Patients With Pancreatic Cancer
Status: RECRUITING
Conditions: Healthy Volunteers|Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: RAD301 ([68Ga]-Trivehexin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Randomized Single-blind Clinical Trial of the Efficacy and Safety of Remimazolam in Painless Bronchoscopy
Status: UNKNOWN
Conditions: Bronchoscopy|Sedation
Interventions: DRUG: Remimazolam|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study To Test A Nasal Spray (Fluticasone Furoate Nasal Spray) For The Treatment Of Perennial (Year-round) Allergic Rhinitis
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial
Interventions: DRUG: Fluticasone furoate nasal spray|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacodynamic Study of Leuprorelin Gelatin-Free Formulation in Female Subjects With Uterine Fibroids.
Status: COMPLETED
Conditions: Uterine Fibroids
Interventions: DRUG: Leuprorelin (GF)|DRUG: Leuprorelin (GC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of 2 Doses of 100µg BG505 SOSIP.664 gp140 Vaccine, Adjuvanted, Given to a Population of Adults Who Have Received 3 Doses of 300µg BG505 SOSIP.GT1.1 gp140 Vaccine, Adjuvanted
Status: ENROLLING_BY_INVITATION
Conditions: Hiv
Interventions: BIOLOGICAL: BG505 SOSIP.664 gp140 Vaccine, Adjuvanted (3M-052 AF plus alum) Dosage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Everolimus in Recipients of Heart Transplants to Prevent Acute and Chronic Rejection
Status: COMPLETED
Conditions: Graft Rejection
Interventions: DRUG: everolimus|DRUG: mycophenolate mofetil|DRUG: cyclosporine|DRUG: corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial on Education Method of Fluterol® Inhalation Inhaler for Asthma Control
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: one-way education|DRUG: two-way education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Immunogenicity of Intradermal Influenza Vaccination in Hemodialysis Patients
Status: COMPLETED
Conditions: Hemodialysis Patients
Interventions: BIOLOGICAL: intradermal influenza vaccine|BIOLOGICAL: intramuscular influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase II Study of Bermekimab (MABp1) in Patients With Moderate to Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Bermekimab Monoclonal Antibody 200 mg|DRUG: Bermekimab Monoclonal Antibody 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing Immunotherapy or Oral Challenges
Status: RECRUITING
Conditions: Hypersensitivity|Anaphylaxis
Interventions: DRUG: Inhaled Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Restoration Margin Level in the Treatment of Gingival Recession Associated With Non-carious Cervical Lesion
Status: ACTIVE_NOT_RECRUITING
Conditions: Gingival Recession, Localized
Interventions: PROCEDURE: Partial restoration approach combined with CAF+CTG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Continued Access Study of the Medtronic CoreValve® System in the Treatment of Symptomatic Severe Aortic Stenosis in Very High Risk Subjects and High Risk Subjects Who Need Aortic Valve Replacement
Status: COMPLETED
Conditions: Severe Aortic Stenosis
Interventions: DEVICE: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study to Evaluate Safety and Immunogenicity of AERAS 404 (C-011-404)
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: AERAS-404 (mcg H4/nmol IC31)|BIOLOGICAL: Sterile buffer containing 10 mmol/L tris and 169 mmol/L NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Shanghai Non-pharmacological Intervention for Mild Cognitive Impairment and Mild Alzheimer's Disease
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Mild Dementia
Interventions: BEHAVIORAL: Diet intervention|BEHAVIORAL: Exercise|BEHAVIORAL: Cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Quadratus Lumborum Block as an Anesthetic Method for Percutaneous Nephrolithotomy
Status: RECRUITING
Conditions: Quadratus Lumborum Block|Percutaneous Nephrolithotomy|Local Anesthesia
Interventions: PROCEDURE: Ultrasound-guided Quadratus Lumborum Block
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on the Efficacy and Safety of Oral All-trans Retinoic Acid Combined With Toripalimab in TNBC.
Status: NOT_YET_RECRUITING
Conditions: Triple-negative Breast Cancer
Interventions: DRUG: ATRA|DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Osteopathic Manipulation in Breastfed Newborns
Status: UNKNOWN
Conditions: Osteopathic Medicine|Breast Feeding
Interventions: OTHER: Sham|OTHER: Osteopathic Manipulation, OMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT