pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Systemic Chemotherapy With or Without Intraperitoneal Chemohyperthermia in Treating Patients Undergoing Surgery for Peritoneal Carcinomatosis From Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin|PROCEDURE: hyperthermia treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b Study of ONL1204 Ophthalmic Solution in Patients With Progressing Open Angle Glaucoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Open Angle Glaucoma
Interventions: DRUG: ONL1204 Ophthalmic solution (Dose A)|DRUG: ONL1204 Ophthalmic solution (Dose B)|PROCEDURE: Sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tele-Yoga Therapy on Patients With Chronic Musculoskeletal Pain During Covid-19 Lockdown
Status: COMPLETED
Conditions: Chronic Musculoskeletal Pain
Interventions: OTHER: Tele-yoga therapy|OTHER: Primary care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preservation of Pancreatic Beta Cell Function Through Insulin Pump Therapy
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: MDI (split-mix NPH insulin + regular insulin or Lantus + Novolog® [or Humalog®])|DEVICE: CSII (Animas Corporation insulin pump, model IR 1200)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PelvEx 4: Advanced Pelvic Malignancy and the Role of the Multi-disciplinary Team Meeting
Status: UNKNOWN
Conditions: Multidisciplinary Communication|Locally Advanced Rectal Cancer|Recurrent Rectal Cancer|Multidisciplinary Team Meeting (MDT)|Treatment Decisions
Interventions: OTHER: No specific intervention; cases are retrospective and patients have already been treated.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Study on the Efficacy and Safety of Multiple Oral Administrations of SHR2285 Tablets in Patients Undergoing Elective Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Prevention of Venous Thrombosis After TKA
Interventions: DRUG: SHR2285 tablet|DRUG: SHR2285 tablet|DRUG: SHR2285 tablet|DRUG: SHR2285 tablet|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Olaparib After Response to Trabectedin-pegylated Liposomal Doxorubicin in Recurrent Ovarian Carcinoma
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Irinotecan Combination Regimen for First-line Treatment of Small Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Irinotecan Hydrochloride Liposome Injection；Carboplatin Injection；Serplulimab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Activity of Belvarafenib as a Single Agent and in Combination With Either Cobimetinib or Cobimetinib Plus Nivolumab in Patients With NRAS-mutant Advanced Melanoma.
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: DRUG: Belvarafenib|DRUG: Cobimetinib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Acute Leukemia|Recurrent B Acute Lymphoblastic Leukemia|Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm|Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Recurrent Hairy Cell Leukemia|Recurrent Hematologic Malignancy|Recurrent Hodgkin Lymphoma|Recurrent T Acute Lymphoblastic Leukemia|Refractory Acute Leukemia|Refractory B Acute Lymphoblastic Leukemia|Refractory Blastic Plasmacytoid Dendritic Cell Neoplasm|Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Refractory Hairy Cell Leukemia|Refractory Hematologic Malignancy|Refractory Hodgkin Lymphoma|Refractory T Acute Lymphoblastic Leukemia|Systemic Mastocytosis
Interventions: DRUG: Acetaminophen|DRUG: Dexamethasone|DRUG: Diphenhydramine|BIOLOGICAL: Flotetuzumab|DRUG: Ibuprofen|DRUG: Ranitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Protein and Amino Acids From Oilseeds in Healthy Volunteers
Status: UNKNOWN
Conditions: Protein
Interventions: DIETARY_SUPPLEMENT: Sunflower|DIETARY_SUPPLEMENT: Rapeseed|DIETARY_SUPPLEMENT: Flaxseed|DIETARY_SUPPLEMENT: Lupin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Preoperative Radiotherapy and Chemotherapy in Patients With Locally Advanced Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: RADIATION: External Beam Radiotherapy|DRUG: Oxaliplatin|DRUG: Fluorouracil|DRUG: Leucovorin|PROCEDURE: Surgical Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Instructed Cognitive Reappraisal in Reducing Affective, Behavioral and Psychophysiological Symptoms of Misophonia
Status: RECRUITING
Conditions: Misophonia Treatment
Interventions: BEHAVIORAL: Cognitive reappraisal|BEHAVIORAL: Schultz Autogenic Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Music Therapy in Sickle Cell Disease Vaso-occlusive Crisis
Status: UNKNOWN
Conditions: Vaso-occlusive Crisis
Interventions: OTHER: Music therapy program MUSIC CARE® + standard care|OTHER: standard care of vaso-occlusive crises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of MLN0002 (300 mg) in the Treatment of Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Vedolizumab|DRUG: Vedolizumab placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-inflammatory Nutritional Intervention in Patients With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: BEHAVIORAL: Anti-inflammatory and low FODMAPs diet|BEHAVIORAL: General healthy eating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PIT: Prophylactic Irradiation of Tracts in Patients With Malignant Pleural Mesothelioma
Status: TERMINATED
Conditions: Mesothelioma
Interventions: RADIATION: Prophylactic Irradiation of Tracts (PIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Universal Hemoglobin A1c Versus Risk-based Screening for Early Gestational Diabetes Mellitus (EARLY GDM): A Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Gestational Diabetes|Large for Gestational Age
Interventions: DIAGNOSTIC_TEST: Hemoglobin A1c|DIAGNOSTIC_TEST: Risk-based screening by ACOG with two-step GTT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Effectiveness and Safety Study of LAP-BAND Treatment in Subjects With BMI >/= 30 kg/m2 and < 40 kg/m2
Status: COMPLETED
Conditions: Obesity
Interventions: DEVICE: LAP-BAND System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Ablation for the Treatment of Large Symptomatic Heterotopic Gastric Mucosa
Status: UNKNOWN
Conditions: Esophagus Disorder
Interventions: DEVICE: Radiofrequency ablation|PROCEDURE: esophagoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Antibiotics Prior to Mini-screw Implant Insertion
Status: COMPLETED
Conditions: Inflammation at Mini-screw Insertion Site|Mobility, Mini-screw
Interventions: DRUG: Amoxicillin|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Relative Bioavailability Study of Gabapentin 400 mg Capsules Under Non-fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Gabapentin 400 mg capsules|DRUG: NEURONTIN® 400 mg capsules|DRUG: Gabapentin 400 mg capsules, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Reproductibility of TM-mode Ultrasound Diaphragm Measures in Patients With Acute Respiratory Distress in the ER
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Adult
Interventions: PROCEDURE: Diaphragm excursion measures 1|PROCEDURE: Diaphragm excursion measures 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Aprepitant Versus Hydroxyzine in Persistent Aquagenic Pruritus for Patients With Myeloproliferative Neoplasms
Status: UNKNOWN
Conditions: Myeloproliferative Disorder|Aquagenic Pruritus
Interventions: DRUG: Aprepitant 80 mg|DRUG: Hydroxyzine 25mg|DRUG: Placebo of Hydroxyzine|DRUG: Placebo of Aprepitant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Efficacy and Tolerance of a Follow-On Milk Containing a Mixture of Prebiotics Fed to Young Children in Salvador, Bahia, Brazil
Status: COMPLETED
Conditions: Gastrointestinal Problems
Interventions: OTHER: Nutritional vanilla flavored beverage - 1) Milk-based beverage containing prebiotics 2) Milk-based beverage containing no prebiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Study With Rituximab-Gemcitabine/Oxaliplatin in Relapsed Indolent Lymphoma
Status: TERMINATED
Conditions: Indolent Lymphoma
Interventions: DRUG: Therapy with Rituximab, Gemcitabine and Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HL-085 in Adults With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas
Status: RECRUITING
Conditions: Neurofibromatosis 1|Plexiform Neurofibromas
Interventions: DRUG: HL-085
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Value of Additional Upfront Systematic Lung Ultrasound in the Workup of Patients With Unilateral Pleural Effusion
Status: COMPLETED
Conditions: Pleural Effusion|Malignant Pleural Effusion|Ultrasound
Interventions: DIAGNOSTIC_TEST: Systematic lung ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nitrofurantoin Macrocrystals 3 Days Versus 7 Days in the Treatment of Women With Uncomplicated Cystitis
Status: WITHDRAWN
Conditions: Cystitis
Interventions: DRUG: NITROFURANTOIN MACROCRYSTALS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing SIBP-04 and Bevacizumab in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Male
Interventions: DRUG: SIBP-04|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Pneumocystis Jirovecii and of Cytomegalovirus in Bronchial Wash Fluid of Patients Undergoing Bronchoscopy
Status: COMPLETED
Conditions: Patients Scheduled for Bronchoscopy
Interventions: OTHER: laboratory testing of PCP and CMV genetic material
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: tDCS and Robotic Therapy in Stroke
Status: COMPLETED
Conditions: Stroke|Upper Extremity Impairments
Interventions: DEVICE: real-tDCS + UE robot-assisted therapy|DEVICE: sham-tDCS + UE robot-assisted therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AST-120 Used to Treat Mild Hepatic Encephalopathy
Status: COMPLETED
Conditions: Mild Hepatic Encephalopathy
Interventions: DRUG: AST-120
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Utility of Continuous Positive Airway Pressure in the Treatment of High Altitude Pulmonary Edema
Status: COMPLETED
Conditions: Continuous Positive Airway Pressure|High Altitude Pulmonary Edema
Interventions: DEVICE: CPAP mask system|DRUG: Nifedipine 30 MG|DEVICE: CPAP mask system without PEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effects of Taking Prenatal Vitamin-mineral Supplements During Lactation on Iron Status and Markers of Oxidation
Status: COMPLETED
Conditions: Iron Overload|Oxidative Stress|Iron-deficiency Anemia
Interventions: DIETARY_SUPPLEMENT: Iron|DIETARY_SUPPLEMENT: Iron|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Randomized Trial Comparing the Lokomat® With a Gait-related Physiotherapy Program in Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DEVICE: Lokomat|OTHER: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Intense Pulsed Light in Patients With Meibomian Gland Dysfunction
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction (Disorder)|Dry Eye Syndromes
Interventions: DEVICE: Intense Pulsed Light|COMBINATION_PRODUCT: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interleukin-2 in Treating Children Who Have Undergone Bone Marrow Transplantation for Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Olaparib (± Degarelix) Given to Men With Intermediate/High Risk Prostate Cancer Before Prostatectomy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Olaparib|DRUG: Degarelix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Determine Whether There Are Any Cognitive or Motor Effects From Taking the Medicine Risperidone.
Status: COMPLETED
Conditions: Oppositional Defiant Disorder|Conduct Disorder|Attention Deficit/Hyperactivity Disorder (ADHD)|Intermittent Explosive Disorder|Impulse-Control Disorders|Adjustment Disorder|Bipolar Disorder|Pervasive Developmental Disorder
Interventions: DRUG: Risperdal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nosocomial Infections During Total Prostatic Cystectomies (TPC) With Replacement Enterocystoplasty: Prophylactic Role of Urell®, Cranberry Fruit Juice Extract (Vaccicium Macrocarpon)
Status: TERMINATED
Conditions: Bladder Cancer
Interventions: OTHER: Infection prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy, Safety and Tolerability of BAF312 Compared to Placebo in Patients With Intracerebral Hemorrhage (ICH).
Status: COMPLETED
Conditions: Hemorrhagic Stroke|Intracerebral Hemorrhage (ICH)
Interventions: DRUG: BAF312 solution|DRUG: Matching Placebo for BAF312 solution|DRUG: BAF312 tablet|DRUG: Matching Placebo for BAF312 tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2, Two-Part Evaluation of the Efficacy and Safety of Locally Administered HTX-011 for Postoperative Analgesia Following Bunionectomy
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: HTX-011|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Loading Dose of Magnesium Sulfate on Uterine, Umbilical, and Fetal Middle Cerebral Arteries Doppler, Biophysical Profile, CTG, Maternal Vital Signs in Women With Severe Preeclampsia
Status: UNKNOWN
Conditions: Preeclampsia
Interventions: DRUG: MgSO4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Leveraging Technology to Achieve Equity for Men With Prostate Cancer on Androgen Deprivation Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: OTHER: STAND-T platform|OTHER: Survey Administration|OTHER: Text Messages
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Simvastatin in the Prevention of Recurrent Pancreatitis
Status: UNKNOWN
Conditions: Pancreatitis Relapsing
Interventions: DRUG: Simvastatin 40mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Time-restricted Eating Versus Daily Continuous Calorie Restriction on Body Weight and Colorectal Cancer Risk Markers
Status: RECRUITING
Conditions: Time Restricted Eating|Obesity|Weight Loss|Colorectal Cancer
Interventions: BEHAVIORAL: Time restricted eating|BEHAVIORAL: Calorie Restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: L-Ascorbic Acid Depletion to Treat Acute Myeloid Leukemia and Myelodysplastic Syndromes
Status: SUSPENDED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: L-Ascorbic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of the Cross-Training in Patients With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Weakness|Fatigue
Interventions: OTHER: Cross-Training healthy subjects|OTHER: Cross-Training multiple sclerosis|OTHER: Standard-training multiple sclerosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Radiation Therapy in Treating Patients With Breast Cancer Undergoing Breast-Conserving Surgery
Status: RECRUITING
Conditions: Stage IA Breast Cancer|Stage IIA Breast Cancer
Interventions: RADIATION: Intraoperative Radiation Therapy|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacitidine Plus Amifostine in Treating Patients With Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: amifostine trihydrate|DRUG: azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effects of the Proprioceptive Neuromuscular Facilitation for Promoting Muscular Irradiation
Status: COMPLETED
Conditions: Motor Disorders
Interventions: OTHER: Upper Limb pattern with flexion - abduction - external rotation|OTHER: Lower Limb pattern with flexion - adduction - external rotation with knee flexion|OTHER: Lower Limb pattern with flexion - abduction - internal rotation with knee flexion|OTHER: Lifting to the right|OTHER: Sit to Stand
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stress Management Intervention for Caregivers of Patients Undergoing Bone Marrow Transplant (BMT)
Status: COMPLETED
Conditions: Hematopoietic/Lymphoid Cancer
Interventions: DEVICE: Paced respiration as part of PEPRR|BEHAVIORAL: PEPRR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Translation of Pritikin Program to the Community
Status: COMPLETED
Conditions: Metabolic Syndrome|Obesity|Weight Loss|Hypertension|Hypercholesterolemia|Hypertriglyceridemia
Interventions: OTHER: Healthy Lifestyle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Sensitivity, Specificity, and Utility of the Reveal® TP (Syphilis) Antibody POCT
Status: RECRUITING
Conditions: Syphilis Infection|Syphilis|Early Syphilis, Symptomatic
Interventions: DEVICE: Reveal TP (Syphilis) Antibody Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Menopausal Treatment Using Relaxation Exercises (MaTURE)
Status: COMPLETED
Conditions: Hot Flushes|Hot Flashes
Interventions: OTHER: Paced Respiration|OTHER: Music Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Molecular Hydrogen in Patients With NAFLD
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: DIETARY_SUPPLEMENT: HRW drink, HRW Natural Health Products Inc., Made in Vancouver, Canada|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A FINEH Protein Trial - Part 1
Status: COMPLETED
Conditions: Diabetes Prevention|Obesity Prevention
Interventions: OTHER: Hemp shake|OTHER: Soybean shake|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Transcutaneous Nerve Electrostimulation (TENS) of Acupuncture Points on Pulmonary Function and Dyspnea Symptoms in Patients With Pulmonary Nodules
Status: UNKNOWN
Conditions: Lung Diseases|Dyspnea|Acupuncture
Interventions: OTHER: transcutaneous nerve electrostimulation (TENS) of acupuncture points
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of AAA617 Alone and AAA617 in Combination With ARPI in Patients With PSMA PET Scan Positive CRPC
Status: RECRUITING
Conditions: Prostatic Neoplasm
Interventions: DRUG: AAA617|DRUG: AAA517|DRUG: Piflufolastat F 18|DRUG: ARPI|DRUG: ADT|OTHER: Best supportive care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: European Study on Prediction of Outcome in Patients With Idiopathic Normal Pressure Hydrocephalus
Status: UNKNOWN
Conditions: Normal Pressure Hydrocephalus
Interventions: PROCEDURE: Ventriculo-peritoneal Shunt
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Sorafenib in Treating Patients With Malignant Gastrointestinal Stromal Tumor That Progressed During or After Previous Treatment With Imatinib Mesylate and Sunitinib Malate
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastrointestinal Stromal Tumor
Interventions: DRUG: Sorafenib Tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weight Loss and Fat Loss
Status: RECRUITING
Conditions: Obesity
Interventions: DRUG: Trevogrumab-Part A|DRUG: Trevogrumab-Part B|DRUG: Garetosmab|DRUG: Semaglutide|DRUG: Matching Placebo-Part A|DRUG: Matching Placebo-Trevogrumab|DRUG: Matching Placebo-Garetosmab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postpartum Immediate Contraception in Cesarean Deliveries-Comparison of Two Intrauterine Systems
Status: COMPLETED
Conditions: Intrauterine Systems|Postpartum Immediate Contraception
Interventions: DEVICE: GyneFix|DEVICE: Cu T380 A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Clinical Trial to Evaluate Efficacy and Safety of TransCon CNP Compared With Placebo in Infants (0 to <2 Years of Age) With Achondroplasia
Status: RECRUITING
Conditions: Achondroplasia
Interventions: DRUG: Navepegritide|DRUG: Placebo for Navepegritide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Isolytic and Static Stretching Training in Individuals With Subacromial Impingement Syndrome
Status: COMPLETED
Conditions: Subacromial Impingement Syndrome
Interventions: OTHER: Isolytic Stretching group|OTHER: Static Stretching group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Laser Treatment for Fresh Surgical Scars and Mature Scars
Status: TERMINATED
Conditions: New Surgical Scars|Scars
Interventions: DEVICE: RevLite (Laser Treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trabeculectomy With Mitomycin C Associated With Sub-conjunctival Injection of Ranibizumab
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: ranibizumab|PROCEDURE: standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety of Tetravalent Rotavirus Vaccine in Healthy Indian Adult Male Volunteers
Status: COMPLETED
Conditions: Rotavirus Gastroenteritis
Interventions: BIOLOGICAL: Live Attenuated Tetravalent (G1-G4) Bovine-Human Reassortant Rotavirus Vaccine (BRV-TV)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of New Oral Treatment for Hepatitis C Virus on Seminal Parameters
Status: COMPLETED
Conditions: Male Infertility|HCV
Interventions: DRUG: Sofosbuvir +daclatasvir+ simeprevir+Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of CYP3A Genetic Polymorphism on the Pharmacokinetics of Phosphodiesterase type5 Inhibitors in Male Subjects
Status: COMPLETED
Conditions: Pharmacokinetics of Three PDE5Is|Healthy Subjects|Genetic Polymorphic CYP3A5
Interventions: DRUG: phosphodiesterase type 5 inhibitor|DRUG: phosphodiesterase type 5 inhibitor|DRUG: phosphodiesterase type 5 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations
Status: RECRUITING
Conditions: Scoliosis|Spinal Deformity|Acute Pain|Chronic Pain|Postoperative Pain|Anesthesia|Regional Anesthesia Morbidity|Anesthesia, Local|Anesthesia Complication|Hyperalgesia|Intraoperative Complications|Intraoperative Hypotension|Intraoperative Blood Loss|Intraoperative Bleeding|Intraoperative Neurological Injury|Intraoperative Injury|Coagulation Disorder|Postoperative Nausea and Vomiting|Postoperative Cognitive Dysfunction|Neuropathic Pain|Nutrient Deficiency|Nutrition Disorders|Ventilator-Induced Lung Injury
Interventions: PROCEDURE: Bilateral bi-level Erector spine plane block|PROCEDURE: General anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NeuroGyn Genital Neuromodulation System for iOAB Treatment
Status: NOT_YET_RECRUITING
Conditions: Overactive Bladder
Interventions: DEVICE: NeuroGyn Genital Neuromodulation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Formulations of Androxal
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: 12.5 mg Androxal Formulation A|DRUG: 12.5 mg Androxal Formulation B|DRUG: 25 mg Androxal Formulation A|DRUG: 25 mg Androxal Formulation B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Equivalence (TE) Study of Propofol 2% MCT Fresenius (MCT=Medium-Chain Triglycerides) Compared With Diprivan® in Patients Undergoing Elective Surgery
Status: COMPLETED
Conditions: General Anesthesia|Elective Surgery
Interventions: DRUG: Propofol|DRUG: Diprivan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Involvement of ACE and Angiotensinogen Genes' Polymorphism Along With Other Thrombophilic Genotypes in Severe Forms of COVID-19 With/Without Thrombotic Events
Status: UNKNOWN
Conditions: Covid19|Corona Virus Infection|Thrombosis|ARDS|Thrombophilia|Thromboses, Intracranial|Thromboses, Deep Vein|RAAS
Interventions: GENETIC: Complete thrombophilic profile testing by multiplex PCR
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Presbyopic Phakic Intraocular Lens for Myopia Correction
Status: COMPLETED
Conditions: Presbyopia|Myopia
Interventions: DEVICE: Presbyopic posterior chamber phakic intraocular lens IPCL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Church-based Health Intervention to Eliminate Racial Inequalities in Cardiovascular Health
Status: RECRUITING
Conditions: Cardiovascular Diseases|Hypertension|Diabetes|Hypercholesterolemia
Interventions: BEHAVIORAL: Evidence-based interventions recommended by the 2019 ACC/AHA Guideline on the Primary Prevention of CVD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior Bevacizumab
Status: COMPLETED
Conditions: Glioblastoma|Glioblastoma Multiforme|Gliosarcoma|Brain Neoplasms|Central Nervous System Neoplasms
Interventions: DRUG: topotecan|DRUG: pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Dapagliflozin in Combination With Metformin XR to Initiate the Treatment of Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Dapagliflozin|DRUG: Metformin XR|DRUG: Metformin XR|DRUG: dapagliflozin matching Placebo|DRUG: metformin HCl Modified Release matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Trial to Compare Two Digital Therapeutics as Interventions for Physical and Mental Health in People With Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer
Interventions: DEVICE: Device: Attune™|DEVICE: Device: Cerena™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: J-Pouch Colorectal Anastomosis or Straight Colorectal Anastomosis in Treating Patients With Rectal Cancer Who Have Undergone Surgery to Remove the Tumor
Status: UNKNOWN
Conditions: Colorectal Cancer|Gastrointestinal Complications|Perioperative/Postoperative Complications
Interventions: OTHER: intraoperative complication management/prevention|PROCEDURE: assessment of therapy complications|PROCEDURE: gastrointestinal complications management/prevention|PROCEDURE: quality-of-life assessment|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT of Counseling Intervention on Post-op Opiate Use
Status: WITHDRAWN
Conditions: Post-operative Pain|Opioid Use|Cesarean Section
Interventions: BEHAVIORAL: Narcotic counseling script|BEHAVIORAL: Post-partum depression counseling script
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Efficacy, Safety and Pharmacokinetics of ASB17061 Capsules in Adult Subjects With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: 5 mg ASB17061|DRUG: Placebo|DRUG: 10 mg ASB17061|DRUG: 20 mg ASB17061
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Protective Efficacy of Flublok® Quadrivalent Versus Licensed Inactivated Influenza Vaccine in Adults ≥50 Years of Age
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Flublok Quadrivalent Influenza Vaccine|BIOLOGICAL: Inactivated Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Liposomal Annamycin for the Treatment of Subjects With Soft-Tissue Sarcomas (STS) With Pulmonary Metastases
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcoma,Soft Tissue|Pulmonary Metastasis
Interventions: DRUG: Liposomal Annamycin (L-Annamycin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Vitamin D3 Supplementation Strategies for Acute Fracture Healing
Status: COMPLETED
Conditions: Fracture
Interventions: DRUG: Vitamin D3|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Anterior vs. Posterior Quadratus Lumborum Block in Nephrectomy Patients
Status: UNKNOWN
Conditions: Quadratus Lumborum Block
Interventions: PROCEDURE: Quadratus Lumborum block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Functional Electrical Stimulation on Gait and Balance in Children With Hemiplegic Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: Traditional Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Counteracting Age-related Loss of Skeletal Muscle Mass (CALM)
Status: COMPLETED
Conditions: Sarcopenia|Muscle Loss
Interventions: PROCEDURE: Heavy Resistance Training|PROCEDURE: Light Intensity Training|DIETARY_SUPPLEMENT: Protein Whey|DIETARY_SUPPLEMENT: Protein Collagen|DIETARY_SUPPLEMENT: Carbohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Alnuctamab in Combination With Mezigdomide in Participants With Relapsed and/or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Alnuctamab|DRUG: Mezigdomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Outcome Measures For Adult CF ACT Trials
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: PROCEDURE: Airway clearance session using the Active Cycle of Breathing Techniques (ACBT)|OTHER: Rest period
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effect of Insole Added to Exercise in Patients With Bilateral Flexible Flatfoot
Status: COMPLETED
Conditions: Flat Feet|Flexible Flatfoot|Balance; Distorted|Muscle Weakness
Interventions: OTHER: Custom made insole|OTHER: Strengthening exercises of extrinsic foot muscles|OTHER: Strengthening exercises of intrinsic foot muscles|OTHER: Standard insole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of a New Needle Navigation Device for CT-guided Interventions to the Conventional Free-hand Method
Status: UNKNOWN
Conditions: Lumbar Pain
Interventions: DEVICE: Free-hand therapeutic CT-guided punction for lumbar pain|DEVICE: Puncture Cube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influenza Vaccination in Prevention From Acute Coronary Events in Coronary Artery Disease - FLUCAD Study
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: BIOLOGICAL: Influenza vaccination: Influvac (SolvayPharma)|BIOLOGICAL: placebo influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: NYCKidSeq: Incorporating Genomics Into Clinical Care of Diverse NYC Children
Status: COMPLETED
Conditions: Genetic Diseases, Inborn|Genetic Predisposition to Disease
Interventions: BEHAVIORAL: Standard of Care|BEHAVIORAL: GUÍA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of the Safety and Efficacy of REGN1033 (SAR391786) in Patients With Sarcopenia
Status: COMPLETED
Conditions: Sarcopenia
Interventions: DRUG: REGN1033 (SAR391786)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ONC-392 and Pembrolizumab in Platinum Resistant Ovarian Cancer
Status: RECRUITING
Conditions: Ovarian Cancer|High Grade Serous Adenocarcinoma of Ovary|Primary Peritoneal Carcinoma|Fallopian Tube Cancer
Interventions: DRUG: ONC-392|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes of Injections in Patients Waiting for Total Knee Replacement
Status: UNKNOWN
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: Hylan G-F 20|DRUG: Triamcinolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Establishment of a Trans-round Window Inner Ear Continuous Drug Delivery System for the Treatment of Severe-to-profound Sudden Sensorineural Hearing Loss
Status: UNKNOWN
Conditions: Hearing Loss, Sudden
Interventions: PROCEDURE: Surgical treatment of round window niche enlargement via round window for inner ear drug delivery|PROCEDURE: Drum chamber drug injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Center Study to Demonstrate the Safety and Performance of Lifelight® First Software Application
Status: COMPLETED
Conditions: Vital Signs
Interventions: DIAGNOSTIC_TEST: Oxygen Saturation (Oximetry)|DIAGNOSTIC_TEST: Heart Rate (Pulse)|DIAGNOSTIC_TEST: Respiratory Rate|DIAGNOSTIC_TEST: Blood Pressure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Stem Cell Transplantation in Ocular Lesions of Behcet's Disease
Status: TERMINATED
Conditions: Retinitis|Behcet's Syndrome
Interventions: BIOLOGICAL: Autologous Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arthroscopic Assisted CC Stabilization Alone VS Additional K-wire Fixation for Acute Acromioclavicular Joint Injury
Status: RECRUITING
Conditions: Acromioclavicular Joint Dislocation
Interventions: DEVICE: K-wire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of Intense Pulse Light Combined With Lipiflow in the Treatment of Meibomian Gland Dysfunction
Status: UNKNOWN
Conditions: Meibomian Gland Dysfunction
Interventions: PROCEDURE: IPL/Lipiflow|PROCEDURE: IPL/MGX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coughing at Time of Cervical Biopsy
Status: RECRUITING
Conditions: Cervical Cancer|Cervical Dysplasia|Colposcopy|Pain Sensation|Cervical Biopsy
Interventions: BEHAVIORAL: Coughing at the time of biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact and Benefit of Physical Activity on Premature Ejaculation
Status: COMPLETED
Conditions: Premature Ejaculation
Interventions: BEHAVIORAL: physical activity|DRUG: dapoxetine 30 mg on demand
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TransCranial Doppler for REDUCtion of Silent strokE During MitraClip Implantation
Status: RECRUITING
Conditions: Mitral Valve Insufficiency
Interventions: PROCEDURE: Sonolysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Tolerability of Oral Lixivaptan Capsules in Subjects With Euvolemic Hyponatremia
Status: COMPLETED
Conditions: Euvolemic Hyponatremia
Interventions: DRUG: Lixivaptan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: QOL-Stereotactic RadioSurgery, Temozolomide + Erlotinib-Rx of 1-3 Brain Metastases in NSCLC
Status: WITHDRAWN
Conditions: Lung Cancer|Metastatic Cancer
Interventions: DRUG: erlotinib hydrochloride|DRUG: temozolomide|RADIATION: stereotactic radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Fully-blinded Parallel Groups Study of Catheter Materials Used for Clean Intermittent Catheterisation
Status: COMPLETED
Conditions: Urinary Catheterization
Interventions: DEVICE: LoFric Primo (POBE) single-use urinary catheter|DEVICE: LoFric Primo (PVC) single-use urinary catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Developing Advanced Blood-Brain Barrier Permeability Imaging for Early AD
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DEVICE: GRASP Dynamic Contrast-Enhanced (DCE) MRI|DEVICE: 3T Brain Scan|DRUG: Gadolinium-based Contrast Agent (GBCA) for MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Defibrotide for Patients With Hepatic Veno-occlusive Disease: A Treatment IND Study
Status: COMPLETED
Conditions: Hepatic Veno-Occlusive Disease
Interventions: DRUG: Defibrotide|DRUG: Defibrotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calorie Restriction With or Without Metformin in Triple Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple-negative Breast Cancer
Interventions: DIETARY_SUPPLEMENT: Fasting-mimicking diet|DRUG: Metformin|DRUG: Preoperative chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monitoring of Hepatitis C Treatment Using Telemedicine - a Clinical Trial in Public Health System in Brazil
Status: UNKNOWN
Conditions: Chronic Hepatitis C
Interventions: OTHER: Telemedicine|DRUG: Velpatasvir/Sofosbuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH