pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: PrOgnostic Implications of PRe-stent Pullback Pressure GradIent and Post-stent Quantitative Flow Ratio in Patients UnderGoing Percutaneous Coronary INtervention
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: Quantitative Flow Ratio derived PPG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Video-based Multicomponent Treatment for Fibromyalgia Plus Face-to-face Sesions
Status: UNKNOWN
Conditions: Fibromyalgia
Interventions: BEHAVIORAL: TAU + multicomponent treatment VIRTUAL FIBROWALK|BEHAVIORAL: Treatment as Usual (TAU)|BEHAVIORAL: TAU + multicomponent treatment VIRTUAL FIBROWALK + 4 face-to-face sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PEAK: Panitumumab Plus mFOLFOX6 vs. Bevacizumab Plus mFOLFOX6 for First Line Treatment of Metastatic Colorectal Cancer (mCRC) Patients With Wild-Type Kirsten Rat Sarcoma-2 Virus (KRAS) Tumors
Status: COMPLETED
Conditions: Colon Cancer|Colorectal Cancer|Rectal Cancer|Metastatic Colorectal Cancer
Interventions: DRUG: Panitumumab|DRUG: Bevacizumab|DRUG: mFOLFOX6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Comparison of the Analgesic Efficacy and Hemodynamic Effects of Paravertebral Block Compared With Paravertebral and Intercostal Nerve Block for Thoracotomy in Adults.
Status: COMPLETED
Conditions: Pain, Postoperative|Nerve Block|Thoracotomy
Interventions: PROCEDURE: Paravertebral block/Intercostal Block (PVB/ICB) group|PROCEDURE: Paravertebral Block (PVB) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH)
Status: COMPLETED
Conditions: Symptomatic Neurogenic Orthostatic Hypotension (NOH)|Non-diabetic Neuropathy|Primary Autonomic Failure|Dopamine Beta Hydroxylase Deficiency
Interventions: DRUG: Placebo|DRUG: Droxidopa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Bundled Rapid HIV/HCV Testing Intervention to Increase Receipt of Test Results
Status: COMPLETED
Conditions: Substance-related Disorders
Interventions: BEHAVIORAL: On-site bundled rapid HIV/HCV testing|BEHAVIORAL: Standard of care (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: LACTYFERRIN™ Forte and ZINC Defense™ and Standard of Care (SOC) vs SOC in the Treatment of Non-hospitalized Patients With COVID-19
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: Sesderma LACTYFERRIN™ Forte and Sesderma ZINC Defense™|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anchoring Sequential Intermittent Long Acting Antimicrobials With Medication for Opioid Use Disorder (MOUD) for Invasive Infections Related to Opioid Use
Status: RECRUITING
Conditions: Substance Use Disorders|Infection, Soft Tissue|Bacteremia|Osteomyelitis Acute|Septic Arthritis
Interventions: DRUG: Oritavancin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Netarsudil Ophthalmic Solution in Japanese/Japanese-American Subjects With Open-angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma or Ocular Hypertension
Interventions: DRUG: AR-13324 Ophthalmic Solution 0.02%|DRUG: AR-13324 Ophthalmic Solution 0.04%|DRUG: AR-13324 Ophthalmic Solution Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: VITAMin Insufficiency in Esophagogastric Neoplasms
Status: RECRUITING
Conditions: Esophageal Cancer|Gastric Cancer|Vitamin Disease|Quality of Life
Interventions: DIETARY_SUPPLEMENT: GIKAVI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study to Evaluate the Effectiveness and Safety of Levemir®, NovoMix® 30 and NovoRapid® in Insulin naïve Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir|DRUG: biphasic insulin aspart 30|DRUG: insulin aspart
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase II Trial of STI571 in the Treatment of Metastatic Gastric Cancer
Status: COMPLETED
Conditions: Recurrent Gastric Cancer|Stage IV Gastric Cancer
Interventions: DRUG: imatinib mesylate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of TAK-079 Administered Subcutaneously as a Single Agent in Participants With Relapsed/Refractory (r/r) Multiple Myeloma (MM)
Status: COMPLETED
Conditions: Relapsed/Refractory|Multiple Myeloma
Interventions: DRUG: Mezagitamab|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study of Drug Sensitivity Prediction Software (IRCR-DReSS) With Patient-derived Tumor Cells of Metastatic Gastric Cancer
Status: COMPLETED
Conditions: Stomach Neoplasms
Interventions: DRUG: Sunitinib|DRUG: Gefitinib|DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sublingual Ketorolac Compared to Intranasal Dexmedetomidine for Postoperative Analgesia in Pediatric Patients Undergoing Bilateral Myringotomy
Status: WITHDRAWN
Conditions: Elective Bilateral Myringotomy
Interventions: DRUG: intranasal dexmedetomidine|DRUG: sublingual ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: HARE-40: HPV Anti-CD40 RNA vaccinE
Status: COMPLETED
Conditions: Human Papilloma Virus Related Carcinoma|Head and Neck Neoplasm|Cervical Neoplasm|Penile Neoplasms Malignant|Unknown Primary Tumors
Interventions: DRUG: BNT113
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib Treatment in Patients With Hepatocellular Carcinoma With Microvascular Invasion After Radical Resection
Status: TERMINATED
Conditions: Hepatocellular Carcinoma|Recurrence
Interventions: DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sociocultural & Biobehavioral Influences on Pain Expression and Assessment
Status: RECRUITING
Conditions: Normal Physiology|Healthy Volunteers|Pain
Interventions: DEVICE: Medoc thermal stimulator|DEVICE: Electric shock stimulator|DEVICE: Cold water bath|BEHAVIORAL: Pain assessment performance feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Facilitating Assessment of At-Risk Sailors Using Technology
Status: COMPLETED
Conditions: Psychological Distress
Interventions: DEVICE: Experimental - Cogito Companion|BEHAVIORAL: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Enhanced Recovery After Surgery in Kidney Transplant Donors
Status: RECRUITING
Conditions: Opioid Use|Kidney Diseases|Pain, Postoperative|Postoperative Complications|Postoperative Nausea and Vomiting
Interventions: PROCEDURE: multimodal pain management|OTHER: goal directed fluid management|OTHER: preoperative carbohydrate loading|PROCEDURE: Donor nephrectomy|PROCEDURE: regional anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Pharmacokinetic, Single Ascending Dose Study of Tesevatinib in Pediatric Subjects With Autosomal Recessive Polycystic Kidney Disease (ARPKD)
Status: COMPLETED
Conditions: Polycystic Kidney, Autosomal Recessive
Interventions: DRUG: Tesevatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Physical Recovery Program for Head and Neck Cancer Patients (3C-CUIDATE)
Status: COMPLETED
Conditions: Head and Neck Cancer|Pain|Dysfunction
Interventions: OTHER: Manual therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EmbryoGlue as an Embryo Transfer Medium
Status: UNKNOWN
Conditions: Infertility
Interventions: BIOLOGICAL: EmbryoGlue® (laboratory culture medium)|BIOLOGICAL: Standard control medium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-Centered, Two-Arm, Randomized Study Comparing the Effects of AAT-023 (Zuragen) Solution, and Heparin on the Incidence of Catheter Related Blood Stream Infections in Tunneled Chronic Central Venous Catheters for Dialysis
Status: UNKNOWN
Conditions: End Stage Renal Disease
Interventions: DEVICE: AAT-023 solution (Zuragen)|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: SBRT and Durvalumab for Inoperable/Unresectable Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Durvalumab|RADIATION: Stereotactic body radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mannitol Improves Cerebral Oxygen Saturation
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Mannitol|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Facilitated Tucking Position's Effect on Comfort and Breastfeeding
Status: COMPLETED
Conditions: Breastfeeding, Exclusive|Position|Preterm Birth
Interventions: BEHAVIORAL: Facilitation Tuchking Position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Improving Phosphate Control in Children With CKD
Status: RECRUITING
Conditions: Chronic Kidney Diseases|Hyperphosphatemia|Pediatric Kidney Disease|CKD-MBD|Chronic Kidney Disease-Mineral and Bone Disorder
Interventions: OTHER: Knowledge questionnaire|OTHER: Focus groups
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of High and Very High riSk Dyslipidemic pAtients for the PreveNTion of CardiOvasculaR Events
Status: COMPLETED
Conditions: Dyslipidemia|Cardiovascular Diseases|Hypercholesterolemia|Atherosclerotic Cardiovascular Disease
Interventions: OTHER: Non-interventional
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Withdrawal Versus Continuation of Amiodarone in Successfully Treated Patients With Persistent Atrial Fibrillation
Status: COMPLETED
Conditions: Persistent Atrial Fibrillation
Interventions: DRUG: withdrawal or continuation of amiodarone therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Simvastatin in Relapsing-Remitting Multiple Sclerosis
Status: UNKNOWN
Conditions: Simvastatin Multiple Sclerosis
Interventions: DRUG: Simvastatin in relapsing remitting multiple sclerosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of BNP7787 for the Prevention of Neurotoxicity in Metastatic Breast Cancer Patients Receiving Weekly Paclitaxel
Status: COMPLETED
Conditions: Breast Neoplasms|Breast Diseases|Metastases, Neoplasm
Interventions: DRUG: BNP7787|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Clinical Character，Risk and Prognosis of Post-neurosurgical Intracranial Infection With Different Pathogens.
Status: UNKNOWN
Conditions: Intracranial Infections|Ventriculitis|Meningitis|Gram-Positive Bacterial Infections|Gram-Negative Bacterial Infections|Neurosurgery
Interventions: OTHER
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Randomized Evaluation of Butyrate Irrigation Before Ileostomy Closure on the Colonic Mucosa in Rectal Cancer Patients (BUTYCLO)
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DRUG: Irrigations trough the efferent limb of loop ileostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of High-Dose Melphalan and Autologous Stem Cell Transplantation in Patients With Primary Light Chain Amyloidosis
Status: COMPLETED
Conditions: Amyloidosis
Interventions: DRUG: Melphalan|PROCEDURE: Autologous Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Investigate Efficacy and Safety Evaluation of Bortezomib in Patients With Relapsed/Refractory Immune Thrombocytopenia
Status: RECRUITING
Conditions: Relapsed/Refractory Immune Thrombocytopenia
Interventions: DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Investigate the Efficacy and Safety of Orally Administered Tolvaptan (OPC-41061) in Patients With Chronic Renal Failure Undergoing Hemodialysis or Hemodiafiltration
Status: COMPLETED
Conditions: Chronic Renal Failure
Interventions: DRUG: OPC-41061|DRUG: OPC-41061|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Intravenous Sufentanil Infusion for Postoperative Pain Management Following Tonsillectomy or Adeno-tonsillectomy in Children
Status: UNKNOWN
Conditions: Sleep Breathing Disorders|Tonsillitis|Adenoid Hypertrophy
Interventions: DRUG: continuous intravenous sufentanil 0.02μg•kg-1•h-1 infusion|DRUG: continuous intravenous sufentanil 0.03μg•kg-1•h-1 infusion|DRUG: continuous intravenous sufentanil 0.04μg•kg-1•h-1 infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neural Correlates During Alcohol Intoxication
Status: RECRUITING
Conditions: Alcohol Use Disorder|Intermittent Explosive Disorder
Interventions: DRUG: Alcohol (Ethanol)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy Evaluation of Hydrolyzed Collagen Peptide on Knees, Hips, and Ankle Pain in Osteoarthritis
Status: UNKNOWN
Conditions: Pain, Joint
Interventions: DIETARY_SUPPLEMENT: Hydrolyzed Collagen Peptide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Imagery Rescripting as a Treatment for Early Psychosis
Status: RECRUITING
Conditions: Psychosis|Psychotic Disorders|Schizophrenia|Psychoses, Traumatic
Interventions: BEHAVIORAL: Imagery Rescripting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Acceptability of Oxygen Saturation Monitoring Using Masimo SafetyNet Alert (MSNA) in a Supportive Housing Program
Status: TERMINATED
Conditions: Opioid Use
Interventions: DEVICE: Masimo SafetyNet Alert (MSNA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cannabidiol for the Treatment of Severe (Grades III/IV) Acute Graft-versus-host Disease
Status: UNKNOWN
Conditions: Acute-graft-versus-host Disease
Interventions: DRUG: Cannabidiol|DRUG: Methylprednisolone|DRUG: Calcineurin inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid to Prevent Bleeding After Endoscopic Resection of Large Colorectal Polyps: A Pilot Project
Status: COMPLETED
Conditions: Polyp, Colorectal
Interventions: DRUG: Tranexamic Acid Injection [Cyklokapron]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Heat Disinfection of HD Water Treatment System in Hemodialysis Patients
Status: COMPLETED
Conditions: All Cause Mortality
Interventions: DEVICE: CWP 103H (Gambro, Sweden): a heat disinfection device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: p16Ink4a in Bronchopulmonary Dysplasia in Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Bronchopulmonary Dysplasia
Interventions: OTHER: Blood punction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nivolumab After Cyclophosphamide and Doxorubicin Induction Therapy in NSCLC With PD-L1<10%
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: CA and Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: F01 in the Treatment of Autoimmune Diseases
Status: RECRUITING
Conditions: Autoimmune Diseases
Interventions: DRUG: After preconditioning with Fludarabine and Cyclophosphamide, F01 will be evaluated.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benefit of Singing in the Care of Premature Children Undergoing Screening for Retinopathy of Prematurity in the Neonatology and Neonatal Resuscitation Unit of the Dijon University Hospital
Status: COMPLETED
Conditions: Prematurity|Eye Fundus
Interventions: OTHER: Positive stimulation (singing)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Manual Therapy and Exercise in Patients With Cervicogenic Headache
Status: COMPLETED
Conditions: Cervicogenic Headache
Interventions: OTHER: Thrust Manipulation|OTHER: Non-thrust Mobilization and Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laryngeal Mask Airway in Pediatric Adenotonsillectomy
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive|Tonsillitis
Interventions: PROCEDURE: ETT with non modified retractor|OTHER: LMA with modified retractor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nuwiq Dosing and Outcomes In the ManagEment of Women/Girls With Haemophilia A Needing FVIII Treatment for Surgery
Status: RECRUITING
Conditions: Hemophilia A
Interventions: DRUG: Nuwiq
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preliminary Assessment of [18F] Fluciclatide (GE [18F]AH111585) in Glioblastoma Multiforme Treated With Bevacizumab
Status: WITHDRAWN
Conditions: Glioblastoma Multiforme (GBM)
Interventions: DRUG: Fluciclitite , PET imaging, and Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Anti-PD-1 AK105 in Patients With Metastatic Nonsquamous Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer Non-small Cell Stage IV
Interventions: BIOLOGICAL: AK105|DRUG: carboplatin|DRUG: pemetrexed|DRUG: placebo|DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial (RCT)Comparing GYNAECARE MORCELLEX Versus ROTOCUT GI Tissue Morcellators
Status: COMPLETED
Conditions: Uterine Myomas
Interventions: PROCEDURE: Laparoscopic myomectomy and supracervical hysterectomy with GYNECARE MORCELLEX|PROCEDURE: Laparoscopic myomectomy and supracervical hysterectomy with ROTOCUT G1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The NEUROlogically-impaired Extubation Timing Trial
Status: UNKNOWN
Conditions: Acute Brain Injury
Interventions: PROCEDURE: Extubation|PROCEDURE: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase 1, Open Label Study of Intravenous GSK3745417 to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Determine RP2D & Schedule in Participants With Relapsed or Refractory Myeloid Malignancies Including AML and HR MDS
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: GSK3745417
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Assessment of Transfemoral Prosthetic Sockets
Status: COMPLETED
Conditions: Amputation|Amputation; Traumatic, Leg, Lower
Interventions: DEVICE: Laminated Socket|DEVICE: Quatro|DEVICE: Infinite Socket|DEVICE: CJ Socket
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Examining Effects of Intrarosa in Women With Genitourinary Syndrome of Menopause/Vulvovaginal Atrophy
Status: UNKNOWN
Conditions: Menopause|Genitourinary Syndrome of Menopause|Vulvovaginal Atrophy|Menopause Syndrome|Dyspareunia
Interventions: DRUG: Intrarosa|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Highest Weight Loss and Abdominal Adiposity Loss With Hypocaloric Diet Plan and Auricular Acupuncture
Status: COMPLETED
Conditions: Weight Loss|Abdominal Obesity
Interventions: DIETARY_SUPPLEMENT: Hypocaloric diet plan|OTHER: Auricular Acupuncture|OTHER: Acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab With Chemotherapy as First Line Treatment in Patients With Advanced Biliary Tract Cancers (aBTCs)
Status: RECRUITING
Conditions: Biliary Tract Cancer
Interventions: BIOLOGICAL: Durvalumab|DRUG: Gemcitabine monotherapy|DRUG: Gemcitabine + cisplatin|DRUG: Gemcitabine + oxaliplatin|DRUG: Gemcitabine + carboplatin|DRUG: Gemcitabine + cisplatin + S-1|DRUG: Gemcitabine + S-1|DRUG: Gemcitabine + cisplatin + albumin-bound paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Minimally Invasive Surgical Assisted by Robots on Intraventricular Hemorrhage
Status: NOT_YET_RECRUITING
Conditions: Clarify the Therapeutic Differences Between Robot Assisted Endoscopic Clearance and Traditional Puncture and External Drainag
Interventions: PROCEDURE: Using robot assisted endoscopy to clear intraventricular hemorrhage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial on Impact on the Hospital Stay, of an Early Oral Nutrition Protocol Applied to Patients After Total Gastrectomy. (DOPGT_2015)
Status: UNKNOWN
Conditions: Early Oral Nutrition After Total Gastrectomy|Gastric Cancer
Interventions: OTHER: Early oral nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Single Arm Phase II Study of Fractionated Stereotatic Radiation Therapy (FSRT) for Bone Metastases in Breast Cancer
Status: RECRUITING
Conditions: Bone Metastases|Breast Cancer
Interventions: RADIATION: Fractionated Stereotatic Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Collection of Liquid Biopsy Samples of Neuroendocrine Neoplasms (NEN) Patients - Collection of NET (CollectNET) 2.0, a Study by the BE-FORCE Consortium
Status: RECRUITING
Conditions: Neuroendocrine Neoplasms
Interventions: DIAGNOSTIC_TEST: Shallow Whole Genome Sequencing (sWGS)-GIPXplore|DIAGNOSTIC_TEST: methylation-sensitive restriction enzymes (MSRE)-Single-molecule molecular inversion probes (smMIP)-seq assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Low-Dose Pentavalent Antimony for Treatment of Cutaneous Leishmaniasis
Status: COMPLETED
Conditions: Cutaneous Leishmaniasis
Interventions: DRUG: Meglumine antimoniate|DRUG: Meglumine antimoniate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of EG-009A Compared to DEX in Patients With COVID-19 Pneumonia
Status: WITHDRAWN
Conditions: COVID-19 Pneumonia
Interventions: DRUG: EG-009A|DRUG: EG-009A Placebo|DRUG: Standard of Care|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non Invasive Assessment of Liver Fibrosis in Children: Comparison of ShearWave Elastography, Fibrotest and Liver Biopsy
Status: COMPLETED
Conditions: Liver Fibrosis|Children
Interventions: PROCEDURE: Shearwave electrography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Kinesiotaping and Post-dry Needling Soreness
Status: COMPLETED
Conditions: Mechanical Neck Pain
Interventions: OTHER: Kinesiotaping|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Community-Based Biofeedback Program on Drug Use and Mental Health Among People Experiencing Homelessness
Status: COMPLETED
Conditions: Heart Rate Variability
Interventions: BEHAVIORAL: Heart Rate Variability - Biofeedback (HRV-BF)|BEHAVIORAL: Health Promotion (HP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Blood Purification Therapy in Critically Ill Patients (GlobalARRT)
Status: RECRUITING
Conditions: Critical Illness|Acute Kidney Injury|Sepsis|Systemic Inflammatory Response Syndrome
Interventions: DEVICE: Commercial membrane for Extracorporeal Blood Purification Therapy (EBPT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Controlled Study of ONO-1101 in Patients With Postoperative Tachyarrhythmias in Japan
Status: COMPLETED
Conditions: Postoperative Supraventricular Tachyarrythmia
Interventions: DRUG: ONO-1101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Administration of Inhaled Dry Powder Mannitol In Cystic Fibrosis - A Safety and Efficacy Study
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Mannitol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Mucoadhesive Sustained Release, Mucodentol, in Comparison With Hydroxychloroquine to Prevent COVID-19
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: Hydroxychloroquine|DRUG: Mucodentol|DEVICE: Personal protective equipment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Comparison Between GUMMETAL and SS Orthodontic Wires in Space Closure
Status: ACTIVE_NOT_RECRUITING
Conditions: Malocclusion, Angle Class I
Interventions: DEVICE: GUMMETAL Orthodontic Wire|DEVICE: Stainless Steel (CrNi)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture in a Multidisciplinary Approach for Vulvodynia and Chronic Pelvic Pain
Status: RECRUITING
Conditions: Vulvodynia|Chronic Pelvic Pain
Interventions: PROCEDURE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0718 Pazopanib and Temsirolimus in Treating Patients With Advanced Solid Tumors
Status: WITHDRAWN
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: pazopanib hydrochloride|DRUG: temsirolimus|PROCEDURE: immunoenzyme technique|PROCEDURE: laboratory biomarker analysis|PROCEDURE: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Radioembolization in Elderly/ Fragile Patients With mCRC
Status: RECRUITING
Conditions: Colorectal Cancer Metastatic
Interventions: DEVICE: radioembolization|DRUG: Standard of care first-line systemic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Study the Safety, Tolerance and Immunogenic Response to MCV4, Tdap and Bivalent rLP2086 Vaccine When Given at the Same Time to Children Between the Ages of 10 Through 12 Years of Age
Status: COMPLETED
Conditions: Vaccines|Meningococcal Vaccines
Interventions: BIOLOGICAL: rLP2086 + MCV4 + Tdap|BIOLOGICAL: MCV4 + Tdap + saline|BIOLOGICAL: rLP2086 + saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TC Plus PD-1 Inhibitors Combined With Anlotinib for Advanced Advanced Esophageal Cancer
Status: UNKNOWN
Conditions: ESCC
Interventions: DRUG: TC/PD-1 inhibitor/anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 68Ga-TCR-FAPI PET/CT Guided Precision Surgery for MTC
Status: RECRUITING
Conditions: Medullary Thyroid Cancer|Prositron Emission Tomography|Fibroblast Activation Protein Inhibitor|Surgery
Interventions: PROCEDURE: Surgery|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Once-Daily Oral Orforglipron (LY3502970) in Japanese Adult Participants With Obesity Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: DRUG: Orforglipron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Left Atrial Appendage Occlusion for AF Patients Unable to Use Oral Anticoagulation Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation|Anticoagulants and Bleeding Disorders
Interventions: DEVICE: Left atrial appendage occlusion (Watchman FLX or Amplatzer Amulet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Group-based and Individual Pelvic Floor Muscle Training on Elderly Individuals With Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: OTHER: Group-based PFMT|OTHER: Individualized PFMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Evaluation of Duodenal Polyposis in Patients With Familial Adenomatous Polyposis (FAP)
Status: COMPLETED
Conditions: Familial Adenomatous Polyposes|Duodenal Polyposis|Duodenal Cancer
Interventions: DIAGNOSTIC_TEST: Esophagogastroduodenoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Topical Anesthesia on Hemodynamics During the Induction Period in Patients Undergo Cardiac Surgery.
Status: COMPLETED
Conditions: Coronary Artery Disease|Valvular Heart Disease|Arrhythmia|Myocardial Disease
Interventions: PROCEDURE: The combined topical anesthesia induction group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CART-38 in Adult AML and MM Patients
Status: RECRUITING
Conditions: Acute Myeloid Leukemia (AML)|Multiple Myeloma (MM)
Interventions: DRUG: 3x10(6) CART-38 cellls|DRUG: 7x10(5) CART-38 cells|DRUG: 7x10(6) CART-38 cells|DRUG: 3x10(7) CART-38 cells|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence and Risk Factors of Epiretinal Membrane in Diabetic and Non-diabetic Patients
Status: COMPLETED
Conditions: Epiretinal Membrane
Interventions: DEVICE: Slit lamp examination|DEVICE: Undilated 7-field color fundus photography|DEVICE: Color scan|DEVICE: Spectral domain optical coherence tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessing the Additional Neoplasia Yield of Computer-aided Colonoscopy in a Screening Setting
Status: RECRUITING
Conditions: Colonic Neoplasms|Colonic Adenocarcinoma|Polyps of Colon|Rectal Neoplasms|Rectal Adenocarcinoma
Interventions: DEVICE: CADe colonoscopy using GI Genius device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Compare Efficacy and Safety of Telmisartan/Hydrochlorothiazide With Telmisartan/Hydrochlorothiazide Plus Amlodipine
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: placebo|DRUG: telmisartan + HCTZ|DRUG: telmisartan + HCTZ|DRUG: amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Computer-assisted Risk Evaluation in the Early Detection of Psychotic Disorders
Status: RECRUITING
Conditions: Psychotic Disorders|Prevention
Interventions: DEVICE: "pronia.ai" medical device for high risk psychosis prognosis|OTHER: Treatment-as-usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bortezomib to Treat Significant Complication of HSCT
Status: COMPLETED
Conditions: Allogeneic Stem Cell Transplantation|Refractory Autoimmune Cytopenia(s)
Interventions: DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trypan Blue Versus Brillant Blue for Epiretinal Membranes
Status: COMPLETED
Conditions: Idiopathic Epiretinal Membranes
Interventions: PROCEDURE: Trypan Blue|PROCEDURE: Brillant Blue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VALID: Study to Compare the Reduction of Predialysis Systolic Blood Pressure With Valsartan Compared to Irbesartan in Patients With Mild to Moderate Hypertension on Long-term Hemodialysis
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: valsartan|DRUG: irbesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy and Safety of a Combination Containing Myo-inositol, D-chiro-inositol, Alpha-lactalbumin, Zinc and Extract of Gymnema Sylvestre in Subjects Diabetic Patients.
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Myo-inositol, D-chiro-inositol, Gymnema sylvestre, Zinc and Alpha-lactalbumin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution in Acute HF
Status: NOT_YET_RECRUITING
Conditions: Heart Failure Acute|Diabetes Type 2|Heart Failure With Reduced Ejection Fraction|Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: Dapagliflozin tablet|DRUG: Hypertonic Saline Solution, 1 Ml|DRUG: Furosemide Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Sedentary to Active Rising to Thrive (START) Trial
Status: RECRUITING
Conditions: Sedentary Time|Frailty
Interventions: BEHAVIORAL: Continuous sedentary reduction intervention|BEHAVIORAL: Bouted sedentary reduction intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Observational Study to Evaluate Safety and Efficacy of Insulin Therapy in Type 2 Diabetes Mellitus Subjects Failing on Oral Anti-diabetic Agents
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: soluble human insulin|DRUG: biphasic human insulin|DRUG: insulin NPH|DRUG: insulin aspart|DRUG: biphasic insulin aspart|DRUG: insulin detemir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Doravirine (MK-1439) in Participants With Human Immunodeficiency Virus 1 (HIV-1) (MK-1439-018)
Status: COMPLETED
Conditions: HIV-1
Interventions: DRUG: Doravirine|DRUG: Darunavir|DRUG: Ritonavir|DRUG: TRUVADA™ or EPZICOM™/KIVEXA™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose and Multiple Dose Study to Assess Safety and Tolerability of LOU064
Status: COMPLETED
Conditions: Healthy Volunteers, Atopic Diathesis and Atopic Dermatitis
Interventions: DRUG: LOU064|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Next-Generation Synbiotic in Individuals With Overweight or Obesity
Status: NOT_YET_RECRUITING
Conditions: Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: Synbiotic Group|OTHER: Placebo Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Response of Hepatic Tumors to Radioembolization
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma|Intrahepatic Cholangiocarcinoma|Liver Metastasis
Interventions: RADIATION: Injection of Ytttrium-90 microspheres into the hepatic artery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study Investigating Local Tolerability and Pharmacokinetics of PXL01 in Healthy Volunteers
Status: COMPLETED
Conditions: Post-surgery Adhesion Formation
Interventions: DRUG: PXL01|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Salivary Interactions With Chemosensations
Status: TERMINATED
Conditions: Diet, Food Choice, Taste
Interventions: OTHER: Epigallocatechin gallate|OTHER: Epigallocatechin gallate control|OTHER: Linoleic acid|OTHER: Linoleic acid control|OTHER: Capsaicin solution|OTHER: Capsaicin control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Head-to-head Comparison of Two Fecal Biomarkers to Screen Children for IBD
Status: COMPLETED
Conditions: Abdominal Pain|Rectal Bloodloss|Diarrhea|Inflammatory Bowel Disease|Crohn's Disease|Ulcerative Colitis|Irritable Bowel Syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: D-dimer Adjusted Versus Therapeutic Dose Low-molecular-weight Heparin in Patients With COVID-19 Pneumonia
Status: UNKNOWN
Conditions: Coronavirus Disease (COVID)19
Interventions: DRUG: low-molecular-weight heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Nitazoxanide in Adults With Acute Uncomplicated Influenza
Status: TERMINATED
Conditions: Influenza
Interventions: DRUG: Nitazoxanide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2a Study to Evaluate the Safety and Tolerability of GM-2505 in Patients With MDD
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DRUG: GM-2505
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RAD001 and Temozolomide in Patients With Advanced Pancreatic Neuroendocrine Tumors
Status: COMPLETED
Conditions: Pancreatic Neuroendocrine Tumor
Interventions: DRUG: RAD001|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Analysis of Cost-effectiveness Between Sulfonylureas and DPP4 Inhibitors in Combination With Metformin in Treatment of Type 2 Diabetic Patients : A Retrospective, Observational Study.
Status: RECRUITING
Conditions: Type 2 Diabetes Mellitus (T2DM), Cost-effectiveness, Sulfonylureas, DPP4 Inhibitors, Metformin
Interventions: DRUG: sulfonylurease with metformin, DPP4 inhibitors with Metformin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Shock Absorbing Insoles on Knee Pain and Walking in Persons With Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: OTHER: Shock Absorbing Insole (SofSole Athletes Plus)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetic Determinants of Cardiovascular Response to Coffee Drinking
Status: COMPLETED
Conditions: Caffeine
Interventions: DIETARY_SUPPLEMENT: Coffee|DIETARY_SUPPLEMENT: Decaffeinated coffee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Proof of Concept Clinical Trial Evaluating the Safety and Efficacy of Eucrisa (Crisaborole) in Patients With Seborrheic Dermatitis
Status: COMPLETED
Conditions: Seborrheic Dermatitis
Interventions: DRUG: Crisaborole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Antichlamydial Treatment on the Rate of Preeclampsia
Status: UNKNOWN
Conditions: Pre-Eclampsia
Interventions: DRUG: Azithromycin 1gm|OTHER: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Tegavivint for the Treatment of Relapsed or Refractory Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Leukemia|Refractory Leukemia
Interventions: DRUG: Decitabine|DRUG: Tegavivint
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Anal Cytologies in Patients With High Grade Cervical Intraepithelial Neoplasia (CIN II and III)
Status: UNKNOWN
Conditions: Anal Carcinoma|Anal Condyloma
Interventions: DIAGNOSTIC_TEST: Search of anal citology alterations
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Gan & Lee Evaluation of New Biosimilar for Type 1 Lispro
Status: WITHDRAWN
Conditions: Diabetes Mellitus, Type 1
Interventions: BIOLOGICAL: Gan & Lee Insulin Lispro Injection|BIOLOGICAL: Humalog
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Prexasertib (LY2606368) in Combination With Ralimetinib in Participants With Advanced or Metastatic Cancer
Status: COMPLETED
Conditions: Advanced Cancer|Metastatic Cancer|Colorectal Cancer|Non-small Cell Lung Cancer
Interventions: DRUG: prexasertib|DRUG: ralimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT