pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Testosterone Effects on Pelvic Floor Muscles
Status: WITHDRAWN
Conditions: Urinary Incontinence|Menopause
Interventions: DRUG: Testosterone Enanthate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risedronate In The Prevention Of Osteoporosis In Osteopenic Postmenopausal Women
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal
Interventions: DRUG: risedronate (HMR4003)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Hypomethylating Properties of Freeze-dried Black Raspberries (BRB) in Patients With Myelodysplastic Syndrome or Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN)
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Freeze-Dried Black Raspberry Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: User Performance of the CONTOUR NEXT and CONTOUR TV3 Blood Glucose Monitoring System (BGMS)
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: Contour Next and Contour TV3 BGMS testing by subjects with and without Diabetes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessing the Feasibility of Including Patients With Peripheral Artery Disease in to an Established Cardiac Rehabilitation Service.
Status: COMPLETED
Conditions: Peripheral Arterial Disease|Cardiovascular Diseases|Intermittent Claudication|Coronary Artery Disease
Interventions: OTHER: Combined - PAD and CAD
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tear Film Stability After Instillation of Over-the-Counter (OTC) Artificial Drops
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: 1st visit Optive, then 2nd visit Systane|DRUG: 1st visit Systane, then 2nd visit Optive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gabapentin for Post-Operative Pain Control and Narcotic Reduction in Scrotal Surgery
Status: COMPLETED
Conditions: Non-obstructive Azoospermia
Interventions: DRUG: Gabapentin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Evaluation of Two Test Materials With a Positive Control When Used as a Patient Preoperative Skin Preparation
Status: COMPLETED
Conditions: Bacteria Microflora Reduction
Interventions: DRUG: Project X 26ml|DRUG: Project X 5.1ml|DRUG: Prevantics Maxi Swabstick
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Open-label, Randomized Trial in Participants Undergoing TAVR to Determine Safety & Efficacy of Bivalirudin vs UFH
Status: COMPLETED
Conditions: Severe Aortic Stenosis|Transcatheter Aortic Valve Replacement|Aortic Valve Replacement
Interventions: DRUG: Bivalirudin|DRUG: Unfractionated Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Skin IaM: An Exploratory Clinical Trial to Evaluate Changes in Skin Appearance, Colour, and/or Texture Following the Induction of a Local Inflammatory Skin Response
Status: COMPLETED
Conditions: Skin Inflammation
Interventions: DRUG: Leukotriene B4|DEVICE: FLIR One|DEVICE: SCIO|DEVICE: MS Band 2|DEVICE: AGE reader|DEVICE: HSI prototype (PARC) hyper-spectral camera|DEVICE: iPhone 7
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vorinostat in Treating Patients With Locally Advanced, Recurrent, or Metastatic Adenoid Cystic Carcinoma
Status: COMPLETED
Conditions: Recurrent Oral Cavity Adenoid Cystic Carcinoma|Recurrent Salivary Gland Carcinoma|Salivary Gland Adenoid Cystic Carcinoma|Stage III Major Salivary Gland Cancer AJCC v7|Stage III Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7|Stage IVA Major Salivary Gland Cancer AJCC v7|Stage IVA Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7|Stage IVB Major Salivary Gland Cancer AJCC v7|Stage IVB Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7|Stage IVC Major Salivary Gland Cancer AJCC v7|Stage IVC Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7|Tongue Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of tDCS in Patients With Moderate to Severe Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: Yband(YDT-201N)|DEVICE: Sham-Yband(YDT-201N)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety of Bitopertin in Participants With Persistent, Predominant Negative Symptoms of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Placebo|DRUG: Bitopertin|DRUG: Antipsychotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Longitudinal Study to Evaluate an Extracellular Matrix (MatriStem®) for the Treatment of Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Neuropathic Diabetic Foot Ulcer
Interventions: DEVICE: MatriStem® [Urinary Bladder Matrix (UBM)]|DEVICE: Mepilex® [Silicone foam dressing]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nitric Oxide (NO) Donors and Inhibitors Study: Study to Evaluate L-Arginine and Aminoguanidine in Asthmatic Subjects
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Aminoguanidine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3185643 and rGlucagon in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3185643|DRUG: rGlucagon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fludarabine and Cytarabine as Continuous Infusion Plus G-CSF Priming for Elderly Patients With Resistant AML
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Fludarabine , cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Warning System
Status: COMPLETED
Conditions: Congestive Heart Failure|Chronic Obstructive Pulmonary Disease|Cancer|Diabetes Mellitus|Obstructive Sleep Apnea
Interventions: OTHER: Early warning system monitoring.|OTHER: routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study With M2ES and Gemcitabine for Patients With Advanced Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: DRUG: M2ES 7.5mg|DRUG: M2ES 15mg|DRUG: M2ES 30mg|DRUG: M2ES 45mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Postoperative Wound Between Dermabond Prineo(2-octyl Cyanoacrylate Adhesive and Polyester Mesh) and Subcuticular Suture in Simultaneous Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Osteoarthritis, Knee Cutaneous Suture, Dermabond, Subcuticular Suture
Interventions: PROCEDURE: DERMABOND™ PRINEO™(2-octyl Cyanoacrylate Adhesive and Polyester Mesh) vs subcuticular nylon suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of KY-0118 in Subjects With Locally Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Neoplasms|Neoplasms by Histologic Type
Interventions: DRUG: KY-0118|DRUG: KY-0118|DRUG: KY-0118
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CB3 Pilot (Communication Bridge: A Person-centered Internet-based Intervention for Individuals With Primary Progressive Aphasia)
Status: COMPLETED
Conditions: Aphasia|Primary Progressive Aphasia|Dementia|Communication|Alzheimer Disease
Interventions: BEHAVIORAL: Communication Bridge™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Emergency Department Visits and Improving Glucose Control in Uncontrolled Type 2 Diabetes Using CGM Sensors at Hospital Discharge
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DEVICE: Continuous Glucose Monitoring Sensor|OTHER: Diabetes Management Instructions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Progressive Relaxation Exercise on Pain Level, Sleep Quality and Analgesic Consumption
Status: RECRUITING
Conditions: Pain Level, Sleep Quality and Analgesic Consumption in Open Heart Surgery
Interventions: BEHAVIORAL: Progressive Relaxation Exercise Practices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Effect of PERT on Patients Undergoing Pancreaticoduodenectomy
Status: RECRUITING
Conditions: Pancreatic Exocrine Insufficiency|Pancreatic Enzyme Replacement Therapy|Pancreaticoduodenectomy
Interventions: DRUG: Pancreatin Enteric-coated Capsules|OTHER: Routine treatment plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy With Isotretinoin and Tamoxifen Expected to Provide Complete Protection Against Severe Acute Respiratory Syndrome Coronavirus
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Drug: Isotretinoin plus Tamoxifen|DRUG: Aerosolized Isotretinoin plus Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estimation of a Maintaining Daily Jarlsberg Cheese-dose
Status: COMPLETED
Conditions: Maintenance Dose|Osteocalcin|Vitamin K Deficiency
Interventions: DIETARY_SUPPLEMENT: Jarlsberg Cheese
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Treatment With Sitagliptin for Reactive Hypoglycemia Secondary to Dysinsulinism
Status: COMPLETED
Conditions: Reactive Hypoglycemia
Interventions: DRUG: Sitagliptin phosphate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ventilator-Associated Pneumonia in Critically Ill COVID-19 vs. Non-COVID-19 Patients
Status: COMPLETED
Conditions: Infections|Critical Illness|Superinfection|Organ Failure, Multiple|Ventilator Associated Pneumonia|Septic Shock
Interventions: OTHER: COVID-19
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety of Use and Efficacy of Pandora for Patients Suffering From Gonarthrosis (PANDORA2)
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Medical Device : HO-1|DEVICE: Medical Device : HS-3|DEVICE: Medical Device : SINOVIAL® ONE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Assessment of T4032 Versus Lumigan® in Ocular Hypertensive or Glaucomatous Patients
Status: COMPLETED
Conditions: Ocular Hypertension|Glaucoma
Interventions: DRUG: Bimatoprost|DRUG: Lumigan®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Outcome of Cetrotide Therapy for Management of Women at High-risk of Ovarian Hyperstimulation Syndrome
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: Cetrorelix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Pharmacogenetic-based Warfarin Dosing Algorithm in Patients
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: GENETIC: Pharmacogenetic anticoagulation|DRUG: Traditional anticoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Systemic Antibiotics on Post-surgical Complications and Patient-centered Outcomes in Patients Undergoing Implant Surgery With Guided Bone Regeneration and Simultaneous Sinus Floor Elevation
Status: RECRUITING
Conditions: Patients Undergoing Oral Implant Therapy
Interventions: DRUG: Amoxicillin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cluster Randomized Trial of Hospitals to Assess Impact of Targeted Versus Universal Strategies to Reduce Methicillin-resistant Staphylococcus Aureus (MRSA) in Intensive Care Units (ICUs)
Status: COMPLETED
Conditions: Methicillin-resistant Staphylococcus Aureus
Interventions: DRUG: Chlorhexidine bath and nasal mupirocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: BIOLOGICAL: Sacituzumab Tirumotecan|DRUG: Pemetrexed|BIOLOGICAL: Tisotumab Vedotin|DRUG: Topotecan|DRUG: Vinorelbine|DRUG: Gemcitabine|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Darolutamide in Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Status: NOT_YET_RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: Darolutamide|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pneumonia Vaccine in Bone Marrow Transplant Recipients: Usefulness of Donor Vaccination
Status: COMPLETED
Conditions: Bone Marrow Transplant
Interventions: BIOLOGICAL: The polysaccharide vaccine used is Pneumovax (Merck vaccines)|BIOLOGICAL: The conjugate vaccine used is Prevnar (Wyeth-Ayerst vaccines)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Comparative Study Between Injection Molding and Additive Manufacturing Complete Denture
Status: ACTIVE_NOT_RECRUITING
Conditions: Complete Denture
Interventions: OTHER: polyamide and 3D printed complete denture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Regorafenib in Frail and/or Unfit for Chemotherapy Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Neoplasms|Metastatic Disease
Interventions: DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-Blind Randomized Crossover Trial to Access Electrocardiogram Effects of HPN-100
Status: COMPLETED
Conditions: Drug Toxicity
Interventions: DRUG: HPN-100|DRUG: HPN-100 or Placebo|DRUG: Placebo|DRUG: Moxifloxacin|DRUG: HPN-100|DRUG: HPN-100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Perioperative Administration of Pregabalin for Pain After Robot-assisted Endoscopic Thyroidectomy
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Pregabalin|DRUG: Vitamin Complex (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone Treatment for Severe Acute Respiratory Distress Syndrome Induced by COVID-19
Status: TERMINATED
Conditions: Respiratory Distress Syndrome, Adult|COVID-19
Interventions: DRUG: Dexamethasone and Hydroxychloroquine|DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Olaparib and Low Dose Radiotherapy for Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Small-cell Lung Cancer|Small Cell Lung Carcinoma
Interventions: DRUG: Olaparib Pill 50 mg|DRUG: Olaparib Pill 100 mg|DRUG: Olaparib Pill 150 mg|DRUG: Olaparib Pill 200 mg|DRUG: Olaparib Pill 250 mg|DRUG: Olaparib Pill 300 mg|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: De-implementation of Low Value Castration for Men With Prostate Cancer
Status: COMPLETED
Conditions: Cancer of Prostate
Interventions: BEHAVIORAL: ADT ORDER CHECK ATTESTATION (OR)|BEHAVIORAL: PROVIDER SCRIPT (SC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Simvastatin Gel on Bone Neoformation in Post-extraction Sockets: a Randomized Controlled Trial
Status: UNKNOWN
Conditions: Alveolar Socket Preservation|Bone Regeneration
Interventions: PROCEDURE: SIM + polypropylene membrane|PROCEDURE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation
Status: RECRUITING
Conditions: Acute Myeloid Leukemia With FLT3/ITD Mutation|Acute Myeloid Leukemia With KMT2A Rearrangement|Acute Myeloid Leukemia With NPM1 Mutation|Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration and Biopsy|DRUG: Gilteritinib|DRUG: Revumenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Effects of IMA-638 on Allergen-Induced Airway Responses in Subjects With Mild Atopic Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: IMA-638 is a biologic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 6-year Clinical Performance of Prefabricated and Composite Veneers ( Componeer)
Status: COMPLETED
Conditions: Dental Diseases|Tooth Discoloration
Interventions: PROCEDURE: Componeer prefabricated veneers|PROCEDURE: Essentia resin composite veneers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases
Status: ACTIVE_NOT_RECRUITING
Conditions: Periodontal Diseases|Gingivitis|Periodontitis
Interventions: PROCEDURE: Non-Surgical Periodontal Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Pioglitazone in Vascular Transcriptional Remodeling
Status: RECRUITING
Conditions: Myocardial Reperfusion Injury
Interventions: DRUG: Pioglitazone 45 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Yoga for the Management of HIV-Metabolic Syndromes
Status: COMPLETED
Conditions: HIV Infections|HIV Metabolic Cardiovascular Syndrome|HIV Lipodystrophy|HIV Metabolic Syndromes|Hypertension
Interventions: BEHAVIORAL: Yoga lifestyle intervention|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis Without the Presence of Nasal Polyps
Status: COMPLETED
Conditions: Chronic Rhinosinusitis
Interventions: DRUG: OPN-375
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Drug Use in Adolescence: Intervening in Parenting Styles
Status: UNKNOWN
Conditions: Substance-Related Disorders
Interventions: BEHAVIORAL: Motivational Interviewing for Change of Parenting Styles|BEHAVIORAL: Psicoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of XL281 in Adults With Solid Tumors
Status: COMPLETED
Conditions: Cancer|Non-small-cell Lung Cancer|Colorectal Cancer|Papillary Thyroid Cancer|Melanoma
Interventions: DRUG: XL281|DRUG: famotidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Intravenous Heme Arginate on Heme Oxygenase-1 Expression (HO-1) and Oxidative Stress in the Human Heart
Status: COMPLETED
Conditions: Myocardial Ischemia
Interventions: DRUG: Heme arginate 3mg/kg|DRUG: Heme arginate 1mg/kg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Antihypertensive Efficacy and Safety of Fimasartan in Hypertension Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Fimasartan|DRUG: Losartan (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cord Blood Transplantation for Sickle Cell Anemia and Thalassemia
Status: COMPLETED
Conditions: Hematologic Diseases|Anemia, Sickle Cell|Beta-Thalassemia|Hematopoietic Stem Cell Transplantation
Interventions: DRUG: Sangstat|DRUG: Cyclophosphamide|DRUG: Busulfan|DRUG: Mycophenolate Mofetil|DRUG: Cyclosporine|PROCEDURE: Cord Blood Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Contraceptive Efficacy and Safety of an Intravaginal Acetic Acid Thermoreversible Gel on Chinese Women.
Status: NOT_YET_RECRUITING
Conditions: Contraceptive Device; Complications
Interventions: DRUG: ancetate gel|DRUG: nonoxinol gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Multi-point Intra-mucosal Injections of Cross-linked Hyaluronic Acid (DESIRIAL®) in the Vaginal Vestibule
Status: COMPLETED
Conditions: Menopause|Dyspareunia
Interventions: DEVICE: DESIRIAL® (Intra-mucosal Injections of Cross-linked Hyaluronic Acid)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of Single Rising and Multiple Oral Doses of Telmisartan / Hydrochlorothiazide (HCTZ) in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Low dose of telmisartan|DRUG: High dose of telmisartan|DRUG: HCTZ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of a Hypoglossal Nerve Implant for the Treatment of Obstructive Sleep Apnea (OSA)
Status: COMPLETED
Conditions: Sleep Apnea Syndromes|Sleep Apnea, Obstructive|Respiration Disorders|Signs and Symptoms, Respiratory|Syndrome, Obstructive Sleep Apnea
Interventions: DEVICE: aura6000 System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effect of Periodontal Debridement, Tongue Cleaning and Mouth Rinsing for the Treatment of Oral Malodour
Status: WITHDRAWN
Conditions: Halitosis
Interventions: PROCEDURE: Periodontal debridement|OTHER: Cetylpyridium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Label Phase I/II Study of the Safety and Dopamine Transporter Binding Properties of C-11 Altropane in Normal Human Subjects and in Subjects With ADHD
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: RADIATION: PET imaging using C-11 altropane as the ligand.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of A Statewide Program to Prevent Early Mortality and to Promote Fitness in Persons With SMI
Status: COMPLETED
Conditions: Schizophrenia|Bipolar Disorder|Schizoaffective Disorder
Interventions: BEHAVIORAL: In SHAPE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy, Safety and Tolerability of Neramexane in Comparison to Placebo in Patients With Subjective Tinnitus
Status: COMPLETED
Conditions: Subjective Tinnitus
Interventions: DRUG: Neramexane mesylate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Observational Study Called FIRST-2.0 to Learn More About the Use of the Study Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Kidney Disease|Type 2 Diabetes Mellitus
Interventions: DRUG: Finerenone (Kerendia, BAY948862)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Study of TQB2223 Injection Combined With AK105 Injection in the Treatment of Advanced Hepatocellular Carcinoma.
Status: NOT_YET_RECRUITING
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DRUG: TQB2223 injection|DRUG: Penpulimab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of KPG-121 Plus Enzalutamide, Abiraterone or Apalutamide in CRPC Patients
Status: COMPLETED
Conditions: Castration-Resistant Prostate Cancer
Interventions: COMBINATION_PRODUCT: Enzalutamide or Abiraterone or Apalutamid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: eGFR Evolution in HCV Patients Receiving SOF-based or SOF-free DAAs
Status: COMPLETED
Conditions: Hepatitis C|Renal Disease|Viral Hepatitis C
Interventions: DRUG: Sofosbuvir / Velpatasvir Oral Tablet|DRUG: Sofosbuvir and Ledipasvir|DRUG: Sofosbuvir Tablets|DRUG: Ombitasvir/paritaprevir/ritonavir|DRUG: Elbasvir / Grazoprevir Oral Tablet|DRUG: Glecaprevir and Pibrentasvir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mepo for Eosinophilic Esophagitis (EoE) Study
Status: COMPLETED
Conditions: EoE|Eosinophilic Esophagitis
Interventions: DRUG: Mepolizumab 300 mg|DRUG: Mepolizumab 100 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Nimustine in Patients With Recurrent High Grade Glioma
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: Bevacizumab|DRUG: Nimustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Tai Chi in Patients With Ankylosing Spondylitis Receiving Anti-tumor Necrosis Factor Alpha Therapy
Status: COMPLETED
Conditions: Spondylitis, Ankylosing
Interventions: OTHER: Tai Chi (exercise)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study of XL765 (SAR245409) in Combination With Temozolomide With and Without Radiation in Adults With Malignant Gliomas
Status: COMPLETED
Conditions: Mixed Gliomas|Malignant Gliomas|Glioblastoma Multiforme
Interventions: DRUG: XL765 (SAR245409)|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RF Surgical Sponge-Detecting System on the Function of Pacemakers and Implantable Cardioverter Defibrillators
Status: COMPLETED
Conditions: Cardiomyopathy|Cardiac Arrhythmia|Heart Failure|Chronic Thromboembolic Pulmonary Hypertension
Interventions: DEVICE: RF Assure Scanning
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Small Versus Large Bite Closure of Emergency Midline Laparotomy
Status: UNKNOWN
Conditions: Hernia, Ventral
Interventions: PROCEDURE: Small Bite|PROCEDURE: Larger bite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Ratio Of Femoral Vein Diameter To Femoral Artery Diameter With Pulse Pressure Variation As A Diagnostic Tool
Status: COMPLETED
Conditions: Mechanically Ventilated Patients
Interventions: PROCEDURE: FVD/FAD ratio guided|PROCEDURE: PPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase IV, a Clinical Trial to Assess Safety and Convenience of the Change From DTG/3TC to BIC/FTC/TAF in People With HIV, Good Virological Control and Neuropsychiatric Vulnerabilities
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections
Interventions: DRUG: BIKTARVY 50Mg-200Mg-25Mg Tablet and Dovato placebo|DRUG: Dovato 50Mg-300Mg Tablet + Biktarvy placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Continuous Measurement of Transcutaneous CO2 for Evaluation of Alveolar Dead Space During Exercise
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive|Lung Diseases, Interstitial|Chronic Heart Failure|Pulmonary Arterial Hypertension|Hyperventilation Syndrome|Healthy
Interventions: OTHER: simultaneous determination of PaCO2 and PtCO2|OTHER: Hyperventilation test|OTHER: Exercise test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Trial of a Single Delivery of SB-061 in Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: SB-061|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ASTX727 and FT-2102 in Treating IDH1-Mutated Recurrent/Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia
Status: WITHDRAWN
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome|Recurrent Acute Myeloid Leukemia|Recurrent Myelodysplastic Syndrome|Refractory Acute Myeloid Leukemia|Refractory Myelodysplastic Syndrome
Interventions: DRUG: CDA Inhibitor E7727/Decitabine Combination Agent ASTX727|DRUG: IDH-1 Inhibitor FT-2102
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neonatologist-performed Lung Ultrasound (NPLUS) to Guide Respiratory Therapy to Prevent Extubation Failure
Status: RECRUITING
Conditions: Neonatal Disease
Interventions: OTHER: NPLUS (neonatologist performed lung ultrasound)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of the Relationship Between Clinical, Imaging and Biological Data in Patients With Squamous Cell Carcinoma of the Tongue
Status: RECRUITING
Conditions: Soft Tissue Tumors of the Tongue|Squamous Cell Carcinoma|Proton Magnetic Resonance Spectroscopy|Transcriptomics
Interventions: OTHER: MRI and MRS acquisitions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effect of Avastin in Juxtafoveal Telangiectasias
Status: WITHDRAWN
Conditions: Telangiectasis
Interventions: DRUG: Bevacizumab|PROCEDURE: Intravitreal injection of Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid Free Anesthesia and Continuous Post-operative Pulse Oximetry Monitoring in the Obese Patient
Status: COMPLETED
Conditions: Anesthesia
Interventions: COMBINATION_PRODUCT: Opioid free|COMBINATION_PRODUCT: opioid group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparing Effects of Conventional Neurorehabilitation With Exoskeleton With High-intensity Gait Training
Status: NOT_YET_RECRUITING
Conditions: Stroke|Gait, Hemiplegic
Interventions: BEHAVIORAL: Exoskeleton mediated gait training|BEHAVIORAL: High intensity gait training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Virtual Reality Training by Novices on Laparoscopic Cholecystectomy in a Porcine Model
Status: WITHDRAWN
Conditions: Gallstones
Interventions: BEHAVIORAL: Virtual reality laparoscopic simulator training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Expression of IL4 Induced Gene 1 in Patients With Cutaneous Melanoma: Value in Prognosis and/or in Predictive Response to Immune Checkpoint Inhibitors
Status: RECRUITING
Conditions: Cutaneous Melanoma
Interventions: BIOLOGICAL: Blood sample|BIOLOGICAL: Cutaneous melanoma biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intra Articular Botox Injection in Treatment of Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis Knees Both
Interventions: DRUG: Botox Injectable Product|DEVICE: Radiofrequancy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Evaluate the ROX Anastomotic Coupler System in Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: ROX Anastomotic Coupler System (ACS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cancer: Rapid Diagnostics and Immune Assessment for SARS-CoV-2 (COVID-19)
Status: COMPLETED
Conditions: Infectious Disease|Cancer|Coronavirus Infection
Interventions: DIAGNOSTIC_TEST: Throat/nose swabs|DIAGNOSTIC_TEST: Saliva collection|DIAGNOSTIC_TEST: Blood collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Proof of Concept (Design Validation) in Patient With Hard to Heal Wounds Such as Pressure Ulcer, Diabetic Foot Ulcer and Leg Ulcer, Leia
Status: TERMINATED
Conditions: Leg Ulcer|Diabetic Foot Ulcer|Pressure Ulcer
Interventions: DEVICE: Leia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients
Status: UNKNOWN
Conditions: Stomach Neoplasms|Colonic Neoplasms|Rectal Neoplasms|Sigmoid Neoplasms|Liver Neoplasms|Kidney Neoplasms|Urinary Bladder Neoplasms|Prostatic Neoplasms|Osteoarthropathy|Fractures, Bone|Gynecologic Cancer
Interventions: DRUG: low-dose neuroleptanalgesia|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Amorphous Calcium Carbonate (ACC) Treatment on Function and Welfare in Late-stage Solid Cancer Subjects
Status: TERMINATED
Conditions: Oncology
Interventions: DRUG: Amorphous Calcium Carbonate (ACC) - Amor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 4-Dimensional CT Derived Ventilation Versus SPECT Aerosol Ventilation in Patients With Thoracic Malignancies
Status: COMPLETED
Conditions: Esophageal Cancer|Lung Cancer
Interventions: PROCEDURE: 4D CT scans|PROCEDURE: Lung Function Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Reducing High-Risk Geriatric Polypharmacy Via EHR Nudges: Pilot Phase
Status: UNKNOWN
Conditions: Fall|Congestive Heart Failure|Chronic Kidney Failure|Adverse Drug Event
Interventions: BEHAVIORAL: Commitment nudge|BEHAVIORAL: Justification nudge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Anxiety and Depression In Patients With Obstructive Sleep Apnoea Before and After Continuous Positive Airway Pressure
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Continuous positive airway pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spinal Marginally Hyperbaric Ropivacaine for Cesarean Delivery
Status: UNKNOWN
Conditions: Anesthesia, Spinal
Interventions: COMBINATION_PRODUCT: hyperbaric ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Secukinumab Compared to Adalimumab in Patients With Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: BIOLOGICAL: Secukinumab|BIOLOGICAL: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo
Status: COMPLETED
Conditions: Benign Paroxysmal Positional Vertigo
Interventions: PROCEDURE: Gufoni|PROCEDURE: Vibration|PROCEDURE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tipifarnib Plus Radiation Therapy After Combination Chemotherapy in Treating Patients With Stage III Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: paclitaxel|DRUG: tipifarnib|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of Carfilzomib in Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL) or Prolymphocytic Leukemia (PLL)
Status: COMPLETED
Conditions: B-cell Chronic Lymphocytic Leukemia|Hematopoietic/Lymphoid Cancer|Prolymphocytic Leukemia|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia
Interventions: DRUG: carfilzomib|OTHER: Cytokine Assessment|OTHER: Pharmacodynamic Studies|OTHER: Proteosome Inhibition Assessment|OTHER: Pharmacogenomic Studies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of High Intensity Exercises in Treatment of Patients With Shoulder Impingement Syndrome
Status: COMPLETED
Conditions: Shoulder Impingement Syndrome
Interventions: OTHER: High intensity shoulder exercise|OTHER: Conventional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Double Blind Controlled Trial Comparing Sugammadex and Neostigmine After Thoracic Anesthesia
Status: TERMINATED
Conditions: Neuromuscular Blockade
Interventions: DRUG: Sugammadex|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Trial of Lamivudine Treatment in HBeAg Negative Chronic Hepatitis B Patients (in Asia)
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Lamivudine/ Placebo 100mg daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety of Vascugel Treatment After Creation of Arteriovenous Access for Hemodialysis Use
Status: COMPLETED
Conditions: Hemodialysis Access
Interventions: BIOLOGICAL: Vascugel|BIOLOGICAL: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Safety, Tolerability and Pharmacokinetics of AZD1940
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: AZD1940|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP
Status: UNKNOWN
Conditions: Bronchopulmonary Dysplasia
Interventions: DEVICE: Minimally invasive surfactant therapy|OTHER: Continuation on CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: LTA Pilot Study of Glucarpidase in Patients With Central Nervous System Lymphoma
Status: RECRUITING
Conditions: Central Nervous System Lymphoma
Interventions: DRUG: Methotrexate|DRUG: Rituximab|DRUG: leucovorin|DRUG: Glucarpidase
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Optimization of Caffeine for HIE
Status: RECRUITING
Conditions: Hypoxic-Ischemic Encephalopathy
Interventions: DRUG: Caffeine citrate 20 mg/kg|DRUG: Caffeine citrate 30 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ADXS-NEO Expressing Personalized Tumor Antigens
Status: TERMINATED
Conditions: Colon Cancer Metastatic|Head and Neck Cancer Metastatic|Metastatic Non-Small Cell Lung Cancer|Urothelial Carcinoma|Metastatic Melanoma
Interventions: BIOLOGICAL: ADXS-NEO|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ-64281802 in Participants With Confirmed Dengue Fever
Status: TERMINATED
Conditions: Dengue
Interventions: DRUG: JNJ-64281802|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Antenatal Pelvic Floor Preparation Techniques for Childbirth
Status: COMPLETED
Conditions: Pregnancy
Interventions: OTHER: Perineal massage|DEVICE: Vaginal Dilator|OTHER: Pelvic floor muscles training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Withdrawal of Treatment for Heart Failure Patients With Recovery From Tachycardia-induced Cardiomyopathy
Status: NOT_YET_RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction|Heart Rhythm Disorder
Interventions: DRUG: GDMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, and Immunogenicity of an RNA Vaccine Candidate Against COVID-19 in Healthy Japanese Adults
Status: COMPLETED
Conditions: SARS-CoV-2 Infection|COVID-19
Interventions: BIOLOGICAL: BNT162b2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION