pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of the Safety, Tolerability, and Antiretroviral Activity of Raltegravir (MK-0518) in Combination With Other Antiretroviral Therapies in Russian Children and Adolescents Infected With Human Immunodeficiency Virus (HIV-1) (MK-0518-248)
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: Raltegravir Film-coated Tablet|DRUG: Raltegravir Chewable Tablet|DRUG: Other Anti-Retroviral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of SGN-15, Antibody-Drug Conjugate, to Treat Hormone Refractory Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: SGN-15 (cBR96-doxorubicin immunoconjugate)|DRUG: Taxotere (docetaxel)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First-In-Human Clinical Trial to Evaluate the Safety, Effectiveness and Surgical Characteristics of CADENCE in Patients With Refractory Glaucoma
Status: COMPLETED
Conditions: Glaucoma
Interventions: DEVICE: Cadence implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Randomized, Placebo- Controlled Study of Intralesional Nivolumab for High-risk Oral Premalignant Lesions
Status: NOT_YET_RECRUITING
Conditions: Premalignant Lesion
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D and Curcumin Piperine Attenuates Disease Activity and Cytokine Levels in Systemic Lupus Erythematosus Patients
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Observe the clinical outcome and inflammatory cytokines levels in patients with systemic lupus erythematosus (SLE) after being supplemented with Cholecalciferol (Vitamin D3) and Curcumin-Piperine.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bone Marrow Stem Cell Treatment for Asherman's Syndrome and Endometrial Atrophy
Status: COMPLETED
Conditions: Asherman's Syndrome|Endometrium; Atrophy, Cervix
Interventions: BIOLOGICAL: Bone Marrow CD133+ Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Paramedical Consultations in Oncological Supportive Care in Outpatients With Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: OTHER: Early oncological supportive care|OTHER: Delayed oncological supportive care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Comparison of Medication Augmentation and PST in the Treatment of Depression in Older Adults
Status: WITHDRAWN
Conditions: Major Depressive Disorder|Dysthymic Disorder|Depressive Disorder Not Otherwise Specified (NOS)
Interventions: DRUG: Aripiprazole|DRUG: Bupropion|BEHAVIORAL: Problem Solving Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Piezoelectric Surgery on Quality of Life and Periradicular Healing After Endodontic Surgery
Status: UNKNOWN
Conditions: Periapical Disease
Interventions: PROCEDURE: piezoelectric surgery|PROCEDURE: conventional bur
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Desoximetasone Spray 0.25% on Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Desoximetasone Spray 0.25%|DRUG: placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Telbivudine Plus Adefovir With Lamivudine Plus Adefovir for the Treatment of Lamivudine-resistant Chronic Hepatitis B at 52 Weeks: A Pilot Study
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: telbivudine plus adefovir|DRUG: lamivudine plus adefovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Message-based Psychotherapy to Once-weekly, Video-based Psychotherapy for Moderate Depression and Anxiety
Status: COMPLETED
Conditions: Depression|Anxiety
Interventions: BEHAVIORAL: Message-based psychotherapy (MBP)|BEHAVIORAL: Video-chat Psychotherapy (VCP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ruxolitinib Phosphate and Azacytidine in Treating Patients With Myelofibrosis or Myelodysplastic Syndrome/Myeloproliferative Neoplasm
Status: RECRUITING
Conditions: Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable|Myelofibrosis Transformation in Essential Thrombocythemia|Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase|Primary Myelofibrosis
Interventions: DRUG: Azacitidine|OTHER: Laboratory Biomarker Analysis|DRUG: Ruxolitinib Phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Safety Study of TMB-365 in HIV-1 Infected Participants
Status: COMPLETED
Conditions: HIV-1-infection
Interventions: BIOLOGICAL: TMB-365
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Buprenorphine Transdermal Patch in Non-cancer Pain of Moderate Intensity
Status: COMPLETED
Conditions: Osteoarthritis|Rheumatoid Arthritis|Lower Back Pain|Joint Pain|Muscle Pain
Interventions: DRUG: Buprenorphine Transdermal Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bupivacaine Liposomal Injection (Exparel) for Postsurgical Analgesia in Patient Undergoing Laparoscopic Bariatric Surgery
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Exparel|DRUG: Bupivacain|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Aerobic Training and Ginkgo Biloba on Lipids Levels in HIV-positive Patients Undergoing Antiretroviral Treatment
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: Aerobic exercise + Ginkgo Biloba Extract|DRUG: Aerobic exercise + Calcined magnesia (placebo)|DRUG: Aerobic exercise + Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gut Hormones in Obesity, Nicotine and Alcohol Dependence
Status: UNKNOWN
Conditions: Obesity|Smoking Cessation|Alcoholism
Interventions: DRUG: Exenatide|BIOLOGICAL: Desacyl ghrelin|BIOLOGICAL: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Examining the Use of Non-Invasive Inhaled Nitric Oxide to Reduce Chronic Lung Disease in Premature Newborns
Status: COMPLETED
Conditions: Bronchopulmonary Dysplasia
Interventions: DRUG: Inhaled Nitric Oxide (iNO)|DRUG: Nitrogen (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 2 Study Using Aliya PEF Plus Pembro for Sarcoma
Status: NOT_YET_RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: COMBINATION_PRODUCT: Aliya Pulse Electric Field sysem and pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Crofelemer on the Gut Microbiome in Healthy Volunteers and in HIV+ Patients With Non-Infectious Diarrhea
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome|Healthy Volunteers|HIV/AIDS|HIV Diarrhea|Human Immunodeficiency Virus
Interventions: DRUG: Crofelemer delayed-release tablets 125mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Village-Integrated Eye Worker Trial II - Pilot
Status: COMPLETED
Conditions: Cataract|Glaucoma|Age Related Macular Degeneration|Diabetic Retinopathy|Refractive Errors
Interventions: OTHER: Community-based screening program|OTHER: Cataract camp program|OTHER: Community health worker program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Hepatic Arterial Infusion of Cisplatin and 5-FU in Biomarker Stratified HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma Non-Resectable
Interventions: DRUG: cisplatin and 5-fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of BBI-4000 Gel in Pediatric Patients With Axillary Hyperhidrosis
Status: COMPLETED
Conditions: Primary Axillary Hyperhidrosis
Interventions: DRUG: Sofpironium Bromide Gel, 15%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Quadratus Lumborum Block Compared to Caudal Bupivacaine/ Neostigmine in Pediatric Lower Abdominal Surgeries
Status: COMPLETED
Conditions: Postoperative Analgesia
Interventions: DRUG: bupivacaine/ neostigmine.|DRUG: bupivacaine/ neostigmine.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Performance Comparison of Masimo O3 Regional Oximetry Sensors in Neonates
Status: TERMINATED
Conditions: Regional Saturation of Oxygen (rSO2)
Interventions: DEVICE: Masimo O3 Neonatal Sensors|DEVICE: 510(k) cleared sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparing a Single-Dose vs. Twice Yearly Zoledronate in Patients With Early Stage Breast Cancer (REaCT-ZOL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Early-stage Breast Cancer
Interventions: DRUG: Zoledronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Profiling for Individualized Treatment Plan for DIPG
Status: COMPLETED
Conditions: Diffuse Intrinsic Pontine Glioma (DIPG)
Interventions: OTHER: Specialized tumor board recommendation|RADIATION: Standard radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebral Activation and Bilateral Stimulation by Cochlear Implantation in Bilateral Deaf Adults
Status: COMPLETED
Conditions: Deafness
Interventions: OTHER: Positron Emission Tomography (PET)|OTHER: Electroencephalogram (EEG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: To Evaluate the Safety and Efficacy of Intracranial Stent Assisted Endovascular Treatment of Intracranial Aneurysms
Status: RECRUITING
Conditions: Intracranial Aneurysm
Interventions: DEVICE: pEGASUS Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics (Including Food Interaction), and Pharmacodynamics of BIA 3-202
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: BIA 3-202|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Commercial Typhoid Tests Validation
Status: UNKNOWN
Conditions: Typhoid Fever
Interventions: DIAGNOSTIC_TEST: 1. SD Bioline Salmonella Typhi IgG/IgM Fast test, 2. Typhidot Rapid IgG/IgM combo test, 3. TUBEX TF test, 4.Typhoid IgG/IgM Combo Rapid Test CE, 5. Enterocheck WB test, 6. Test-itTM Typhoid IgM test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clozapine Versus Other Atypical Antipsychotics for Bipolar Disorder
Status: UNKNOWN
Conditions: Bipolar Disorder
Interventions: DRUG: Clozapine|DRUG: Risperidone|DRUG: Olanzapine|DRUG: Quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Effect of Kaletra on CD4 Response in HIV Positive (+) Patients With Viral Suppression KIMBO Study
Status: TERMINATED
Conditions: HIV
Interventions: DRUG: Lopinavir/Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Impact of the Update SMM Criteria on the Natural History of SMM to Establish New Recommendations.
Status: ACTIVE_NOT_RECRUITING
Conditions: Smoldering Multiple Myeloma
Interventions: PROCEDURE: Myelogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Tiotropium +Olodaterol Fixed Dose Combination (FDC) Versus Tiotropium and Olodaterol in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: tiotropium + olodaterol|DRUG: tiotropium + olodaterol|DRUG: tiotropium|DRUG: tiotropium|DRUG: olodaterol|DEVICE: Respimat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Prediction of Optimal Pediatric Endotracheal Tube Size "Aged Based Formula Versus Ultrasonography"
Status: COMPLETED
Conditions: Anesthesia Intubation Complication
Interventions: OTHER: ultrasound guided
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Intraoperative Haemodynamic Optimization Comparing Flow and Pressure Parameters
Status: COMPLETED
Conditions: Major Abdominal Surgery|Duodenohemipancreatectomy|Rectal Resection|Extensive Bowel Surgery
Interventions: PROCEDURE: Flow group|PROCEDURE: Press group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of Dexlansoprazole From Doxirazole 60 mg Capsules (Hikma Pharma,Egypt)and Dexilant 60 mg Delayed Release (DR) Capsules (Takeda Pharmaceuticals America Inc., USA)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Doxirazole|DRUG: Dexilant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Position Change and Back Massage Versus Early Ambulation on Post Transfemoral Coronary Angiography Complications
Status: COMPLETED
Conditions: Catheter Complications|Ambulation Difficulty|Bleeding|Back Pain|Oozing|Hematoma
Interventions: OTHER: Position change and back massage|OTHER: Early ambulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TTA in Treatment of Diabetes and Dyslipidemia
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Dyslipidemia
Interventions: DRUG: Tetradecylthioacetic acid (TTA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Aiming to Assess the Safety and Activity of the Combination of Cabozantinib Plus Lanreotide in GEP and NET
Status: UNKNOWN
Conditions: Metastatic Well Differentiated Neuroendocrine Neoplasm|Neuroendocrine Tumors
Interventions: DRUG: Cabozantinib|DRUG: Lanreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The FEMA Study: Feasibility of Exercise in Patients With Metastatic Breast Cancer and Adiposity
Status: RECRUITING
Conditions: Metastatic Breast Cancer|Estrogen-receptor-positive Breast Cancer|Adiposity
Interventions: BEHAVIORAL: Physical Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Amoxicillin Diffusion in Breast Milk According to a Population Pharmacokinetic Approach (CONCEPTION-AMOX)
Status: COMPLETED
Conditions: Breast Feeding, Exclusive
Interventions: BIOLOGICAL: Blood and milk samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Diluted Betadine vs Antibiotic Installation Before Surgical Wound Closure in Prevention of Post Cardiac Surgery Wound Infection
Status: UNKNOWN
Conditions: Surgical Wound Infection
Interventions: DRUG: Betadine|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Relational Agents in Cervical Cancer Education (RACE)
Status: COMPLETED
Conditions: Cervix Cancer|Human Papilloma Virus|Vaginal Cancer|Vulvar Cancer
Interventions: OTHER: Control|OTHER: Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Two New Medical Instruments Dedicated to the Sentinel Lymph Node Technique in Case of Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DEVICE: peroperative scintillating probe|DEVICE: operative gamma camera
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventive Effect of Limited Decompression on Adjacent Segment Following Posterior Lumbar Interbody Fusion
Status: RECRUITING
Conditions: Degenerative Lumbar Spinal Stenosis|Degenerative Disc Disease|Degeneration Spine
Interventions: PROCEDURE: Limited decompressions at adjacent segment with asymptomatic pre-existing spinal canal stenosis|PROCEDURE: Responsible segments fused
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative and Postoperative Analgesia for Laparoscopic Surgery.
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: morphine|DRUG: intrathecal analgesia (morphine)|DRUG: general anesthesia (fentanyl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of HMR1766 in Patients With Fontaine Stage II Peripheral Arterial Disease
Status: COMPLETED
Conditions: Intermittent Claudication
Interventions: DRUG: ataciguat (HMR1766)|DRUG: placebo|DRUG: cilostazol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Cold Immersion on Patients With Varicose Vein
Status: NOT_YET_RECRUITING
Conditions: Varicose Veins of Lower Limb
Interventions: OTHER: Cold water immersion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase II High Dose Brachytherapy and Low Dose Rate Brachytherapy as Monotherapy in Localized Prostate Cancer
Status: RECRUITING
Conditions: Prostate Carcinoma
Interventions: RADIATION: Low dose rate brachytherapy|RADIATION: High dose rate brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cost- Effectiveness and Cost-utility of Laparoscopic Versus Open Repair of Ventral Hernia
Status: COMPLETED
Conditions: Hernia, Ventral
Interventions: PROCEDURE: Laparoscopic ventral hernia repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial Pain
Status: RECRUITING
Conditions: Craniofacial Pain|Migraine|Cluster Headache|Trigeminal Autonomic Cephalgia|Sphenopalatine Ganglion Neuralgia|Paroxysmal Hemicrania
Interventions: DRUG: Exparel (Bupivacaine Liposome)|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of NBF-006 in Non-Small Cell Lung, Pancreatic, or Colorectal Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer|Pancreatic Cancer|Colorectal Cancer
Interventions: DRUG: NBF-006
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Imvotamab in Active, Refractory Idiopathic Inflammatory Myopathies
Status: RECRUITING
Conditions: Idiopathic Inflammatory Myopathies|Inflammatory Myopathies
Interventions: DRUG: Imvotamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1b Study of Indibulin in Combination With Capecitabine in Advanced Solid Tumors
Status: UNKNOWN
Conditions: Advanced Solid Tumors
Interventions: DRUG: indibulin|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visual Performance of Dailies Total1 Multifocal and Acuvue Oasys Max 1-Day Multifocal in Presbyopic Lens Wearers
Status: RECRUITING
Conditions: Presbyopia
Interventions: DEVICE: Deleficon A (multifocal)|DEVICE: Senofilcon A (multifocal)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MyopiaX Treatment for the Reduction of Myopia Progression in Children and Adolescents: Safety and Efficacy Investigation
Status: ACTIVE_NOT_RECRUITING
Conditions: Myopia
Interventions: DEVICE: MyopiaX|DEVICE: Myopia control spectacles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of MK-1293 Versus Lantus™ in Participants With Type 2 Diabetes Mellitus (MK-1293-006)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: MK-1293|DRUG: Lantus™|DRUG: Prandial insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bilateral vs. Unilateral Erector Spinae Plane Block
Status: COMPLETED
Conditions: Postoperative Pain|Cholecystitis; Gallstone
Interventions: PROCEDURE: Bilateral ESP Block|PROCEDURE: Unilateral ESP Block|DEVICE: Intravenous Morphine patient controlled analgesia device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of a Polyphenol-enriched Fruit Drink on Metabolic Health(2)
Status: COMPLETED
Conditions: Healthy Men and Women
Interventions: DIETARY_SUPPLEMENT: Very low polyphenol fruit based drink (control)|DIETARY_SUPPLEMENT: Polyphenol-enriched fruit-based drink - low|DIETARY_SUPPLEMENT: Polyphenol-enriched fruit-based drink - high
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Novel, Individualized Brain Stimulation, Network-based Approaches to Improve Cognition
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Healthy Aging
Interventions: DEVICE: tACS|DEVICE: TMS|DEVICE: TIS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Tegoprazan or RAPA113 on Pharmacodynamics/Pharmacokinetics of Clopidogrel in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Clopidogrel 75mg|DRUG: Tegoprazan 50 mg|DRUG: RAPA113
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Cortical Neurostimulation For Diabetic Neuropathic Pain
Status: RECRUITING
Conditions: Diabetic Neuropathy, Painful|Diabetes Mellitus, Type 1
Interventions: DEVICE: Sooma Oy (tDCS), Helsinki, Finland|DEVICE: Sooma Oy (Sham), Helsinki, Finland
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of TRE With Lactobacillus Plantarum LP-KFY04 Supplementation on Overweight / Obese Individuals
Status: RECRUITING
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Lactobacillus plantarum LP-KFY04|OTHER: Take placebo in addition to the limited diet.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Repurposed Use of Allergic Rhinitis and Allergic Asthma Drug to Reduce Vertigo and Hearing Loss in Meniere's Disease
Status: RECRUITING
Conditions: Meniere Disease|Allergic Rhinitis|Vertigo
Interventions: DRUG: Montelukast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Effectiveness of Direct-acting Antiviral Drugs in the Treatment of Hepatitis C in Patients With Inflammatory Bowel Disease: National Multicenter Study
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|Hepatitis C Virus Infection
Interventions: DRUG: Assess the effectiveness and safety of DAAs in patients with IBD.|DRUG: Evaluate the interaction of DAAs with IBD drugs, particularly immunosuppressants and/or biologics.|OTHER: Assessment of the impact of DAAs on the course of IBD.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Paclitaxel, Cisplatin, and Filgrastim Combined With Radiation Therapy in Treating Patients With Locally Recurrent Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: cisplatin|DRUG: paclitaxel|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mapping of the Human Brainstem During Continence and Micturition: Noninvasive 7-T fMRI Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DIAGNOSTIC_TEST: Magnetic Resonance Imaging (MRI)|DIAGNOSTIC_TEST: Post-Void Residual|DIAGNOSTIC_TEST: Uroflowmetry|BEHAVIORAL: Questionaire - AUA Symptom Score
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunogenicity and Safety of an Inactivated SARS-CoV-2 Vaccine (Sinopharm BBIBP-CorV) Coadministered With Rabies Vaccine
Status: UNKNOWN
Conditions: COVID-19|Rabies
Interventions: BIOLOGICAL: coadministration|BIOLOGICAL: COVID-19 vaccine|BIOLOGICAL: rabies vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Significance of Vitamin D Storage in Adipose Tissue
Status: WITHDRAWN
Conditions: Obesity
Interventions: DRUG: cholecalciferol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Dietary Nitrate in Hypertensive Pregnant Women
Status: COMPLETED
Conditions: Hypertension|Pregnancy
Interventions: DIETARY_SUPPLEMENT: Beetroot juice|DIETARY_SUPPLEMENT: Nitrate-depleted beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of the World Health Organization (WHO) Formulation of the 2004-2005 Fluzone® Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluzone®: Influenza virus vaccine 2004-2005 formulation|BIOLOGICAL: Fluzone®: Influenza virus vaccine 2004-2005 formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Surgery and Active Surveillance in the Treatment of Bosniak III Renal Cysts
Status: NOT_YET_RECRUITING
Conditions: Cystic Renal Disease|Kidney Cancer|Surgery
Interventions: PROCEDURE: Delayed surgery|PROCEDURE: Immediate surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impar VS Coccygeal Block in the Treatment of Coccidine
Status: ACTIVE_NOT_RECRUITING
Conditions: Coccyx Injury|Coccygeal Body Tumor
Interventions: DEVICE: Pericoccygeal nerve block|PROCEDURE: Impar ganglion block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acalabrutinib With R-CHOP in Previously Untreated Mantle Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Acalabrutinib|DRUG: R-CHOP chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incidence of White Spot Lesions Around Ceramic Brackets Compared With Metal Brackets
Status: ACTIVE_NOT_RECRUITING
Conditions: White Spot Lesion of Tooth
Interventions: OTHER: Orthodontic fixed appliance therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Efficacy and Safety of MBA-P01 in Subjects With Glabellar Lines
Status: COMPLETED
Conditions: Glabellar Frown Lines
Interventions: DRUG: MBA-P01|DRUG: BOTOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety of AVTX-803 in Patients With Leukocyte Adhesion Deficiency Type II
Status: RECRUITING
Conditions: Leukocyte Adhesion Deficiency
Interventions: DRUG: AVTX-803 (L-Fucose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of TACI-antibody Fusion Protein Injection (RC18) in Subjects With Inadequate Response to TNF-α Antagonists Due to Treat Moderate and Severe Rheumatoid Arthritis
Status: TERMINATED
Conditions: Moderate and Severe Rheumatoid Arthritis
Interventions: DRUG: Placebo plus MTX|DRUG: RC18 160 mg plus MTX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Patients With Dry Mouth and Sticky Saliva During Radiotherapy
Status: COMPLETED
Conditions: Xerostomia
Interventions: DEVICE: Visco-ease|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acupuncture for Post-tonsillectomy Pain Control in Children
Status: COMPLETED
Conditions: Tonsillectomy|Post-Operative Pain|Acupuncture
Interventions: DEVICE: acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Mesh Placement During Stoma Closure After Low Anterior Resection
Status: RECRUITING
Conditions: Neoplasms Malignant|Rectal Cancer|Hernia Incisional|Surgery
Interventions: PROCEDURE: mesh|PROCEDURE: non-mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating the Safety, Immunogenicity and Tolerability of Meningococcal Group B Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Meningitis, Meningococcal
Interventions: BIOLOGICAL: MnB rLP2086
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A 5 Year Clinical Investigation on Creos Xenoprotect
Status: TERMINATED
Conditions: Implant
Interventions: DEVICE: creos xenoprotect|DEVICE: Bio-Gide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ledipasvir/Sofosbuvir Fixed-Dose Combination for 8 Weeks in Subjects With Chronic Genotype 1 HCV and HIV-1 Co-infection
Status: COMPLETED
Conditions: Treatment of Hepatitis C
Interventions: DRUG: Ledipasvir/Sofosbuvir FDC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study on Fertility Conservative Treatment of Atypical Endometrial Hyperplasia in Singapore
Status: UNKNOWN
Conditions: Endometrial Hyperplasia|Fertility Issues|Disease Regression|Treatment Side Effects
Interventions: DRUG: Mirena|DRUG: Megace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Types of Progesterone in the Prevention of Preterm Labor
Status: UNKNOWN
Conditions: Preterm Labor
Interventions: DRUG: 17 alpha hydroxyprogestrone caproate|DRUG: Vaginal progesterone|DRUG: Oral dydrogesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination of Metronomic Capecitabine With Camrelizumab for Treatment of Refractory Solid Tumor Trial (Cohort 3)
Status: RECRUITING
Conditions: Hepatobiliary, Pancreatic and Other Gastrointestinal Carcinoma (Non-stomach, Non-esophagi)
Interventions: DRUG: Capecitabine, Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enbrel Versus Placebo With Radiation Therapy to Combat Fatigue and Cachexia
Status: TERMINATED
Conditions: Lung Cancer|Prostate Cancer|Neoplasm Metastasis|Bone Cancer
Interventions: DRUG: Enbrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Biodentine as an Apical Plug in Immature Permanent Molars
Status: COMPLETED
Conditions: Periapical Periodontitis
Interventions: OTHER: Biodentine|OTHER: MTA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pulse Wave Velocity, Pulse Wave Morphology and Blocking of the Reninangiotensin System in Patients With Chronic Kidney Disease
Status: UNKNOWN
Conditions: Kidney Failure, Chronic|Cardiovascular Diseases
Interventions: DRUG: Candesartan and enalapril|DRUG: candesartan and enalapril|DRUG: candesartan and enalapril|DRUG: candesartan and enalapril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction Erlotinib Therapy in Stage III A (N2) Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: neoadjuvant erlotinib therapy|DRUG: neoadjuvant gemcitabine/carboplatin therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sodium-glucose Cotransporter Type 2 Inhibitors for Acute Cardiorenal Syndrome Prevention
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: DRUG: Standard list of drugs used for acute decompensation of CHF (loop diuretics, vasodilators, digoxin, inotropic agents, vasopressors), plus dapagliflozin (Forxiga; MP-002596)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Patients With Cancer of the Esophagus
Status: TERMINATED
Conditions: Adenocarcinoma of the Esophagus
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety And Tolerability Study Of RN564 In Women With Osteopenia And Healthy Men.
Status: COMPLETED
Conditions: Osteopenia|Osteoporosis|Bone Disease
Interventions: BIOLOGICAL: RN564
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Response Adaptive Radiotherapy Following Immunotherapy-based Induction for Non-HPV Related HNSCC
Status: RECRUITING
Conditions: Head and Neck Cancer
Interventions: RADIATION: radical radiotherapy (60Gy)|RADIATION: radical radiotherapy (66Gy)|RADIATION: radical radiotherapy (70Gy)|COMBINATION_PRODUCT: anti-PD-1 or PD-L1 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First Time in Human Study in Healthy Volunteers and Patients
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: V565|DRUG: V565|DRUG: Placebo|DRUG: V565|DRUG: V565
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: It's Your Game: An Innovative Approach to Preventing Teen Dating Violence
Status: COMPLETED
Conditions: Adolescent Behavior|Interpersonal Relationships|Domestic Violence|Physical Violence
Interventions: BEHAVIORAL: Me & You: Building Healthy Relationships
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Oral Bioavailability of Curcumin From Micronized Powder and Liquid Micelles in Healthy Young Women and Men
Status: COMPLETED
Conditions: Pharmacokinetics of Novel Curcumin Formulations|Safety of Novel Curcumin Formulations
Interventions: DIETARY_SUPPLEMENT: curcumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Novel Diagnostic Tests for COVID-19
Status: UNKNOWN
Conditions: Acute Disease|Coronavirus|Respiratory Viral Infection
Interventions: DIAGNOSTIC_TEST: SAMBA II (Diagnostic for the Real World)|DIAGNOSTIC_TEST: Public Health England Gold Standard|DIAGNOSTIC_TEST: Cambridge Validated Viral Detection Method|DIAGNOSTIC_TEST: Radiological Detection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Evaluation of Everolimus Eluting Coronary Stents in the Treatment of Patients With ST-segment Elevation Myocardial Infarction: EXAMINATION Study
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: Everolimus Eluting Coronary Stent System|DEVICE: cobalt chromium balloon expandable stent ( non drug eluting stent Arm)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Open-glottis Pushing Technique Versus the Valsalva Pushing Technique in the Second Stage of Labor
Status: COMPLETED
Conditions: Evidence-Based Practice|Labor; Prolonged, Second Stage|Labor|Fetal Acidosis Complicating Labor and Delivery
Interventions: OTHER: Spontaneous pushing technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Study of Efficacy and Safety of MEXIDOL®
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: MEXIDOL® (ethylmethylhydroxypyridine succinate)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study Of 4 Mg Fesoterodine Extended-Release Tablets (Toviaz™) In Healthy Subjects
Status: COMPLETED
Conditions: Treatment of Overactive Bladder
Interventions: DRUG: Fesoterodine|DRUG: Fesoterodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Adolescent Screening and Personalized Intervention Resource for Enhancement of Behavioral Health and Substance Use
Status: RECRUITING
Conditions: Substance Use|Mental Health Issue
Interventions: BEHAVIORAL: ePACE Personalized Intervention|BEHAVIORAL: eFACE Fixed Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Diesel Exhaust Particles (DEP) With and Without Organic Compounds on the Allergic Inflammation in Asthmatic Subjects
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: Bonchoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Levonorgestrel in Preventing Ovarian Cancer in Patients at High Risk for Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Levonorgestrel|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Inferior Alveolar Nerve Block in Fracture Mandibular Surgeries
Status: RECRUITING
Conditions: Anesthesia
Interventions: PROCEDURE: bilateral inferior alveolar nerve block|DRUG: Ketorolac and fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Transfers of Thawed Blastocysts Versus Blastocysts Derived From Thawed Bipronuclear Oocytes
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: Blastocyst cryopreservation|PROCEDURE: Bipronuclear oocyte cryopreservation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Feasibility of Providing a Family Skills Intervention "Strong Families" for Families in the Philippines.
Status: ENROLLING_BY_INVITATION
Conditions: Parenting Skills|Family Relationship
Interventions: BEHAVIORAL: Psychosocial intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Assessment of the Effects of Silk Pillowcases on Acne Prone Skin
Status: NOT_YET_RECRUITING
Conditions: Acne Vulgaris
Interventions: OTHER: Silk Pillowcase|OTHER: Cotton Pillowcase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of BIA 9-1067 in Healthy Japanese and Caucasian Subjects
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: BIA 9-1067|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sedentary Postmenopausal Women With Nonalcoholic Fatty Liver Disease (NAFLD) Submitted to Physical Activity
Status: COMPLETED
Conditions: Fatty Liver
Interventions: BEHAVIORAL: Continuous Aerobic Training twice|BEHAVIORAL: Healthy Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GATE: Generalized Anxiety - A Treatment Evaluation
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Stress Education|BEHAVIORAL: Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interactions Between Artemether-lumefantrine and Antiretrovirals in HIV-patients With Uncomplicated Malaria in Tanzania
Status: COMPLETED
Conditions: Malaria, Falciparum|HIV Infections
Interventions: DRUG: Artemether-lumefantrine (AL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine, Trastuzumab, and Pertuzumab in the Treatment of Metastatic HER2-Positive Breast Cancer After Prior Trastuzumab/Pertuzumab, or Pertuzumab Based Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic HER2-Positive Breast Cancer
Interventions: DRUG: Gemcitabine|DRUG: Trastuzumab|DRUG: Pertuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Arterial Blood Pressure and Cardiac Index-based Hemodynamic Management on Postoperative Myocardial Injury
Status: COMPLETED
Conditions: Myocardial Injury|Perioperative/Postoperative Complications
Interventions: OTHER: Mean arterial pressure based management|OTHER: Cardiac index based management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION