pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Assessing Motor Neuron Disease Mechanisms by Threshold Tracking Transcranial Magnetic Stimulation and Magnetic Resonance Spectroscopy
Status: WITHDRAWN
Conditions: Amyotrophic Lateral Sclerosis|Motor Neuron Disease|Cortical Excitability
Interventions: DIAGNOSTIC_TEST: MRS, conventional TMS and treshold tracking TMS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: COOL RCN: Cooling to Prevent Radiocontrast Nephropathy
Status: TERMINATED
Conditions: Renal Failure|Kidney Failure|Renal Insufficiency
Interventions: DEVICE: Reprieve Endovascular Temperature Therapy System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability of NOVA63035 "Corticosteroid" in Patients With Diabetic Macular Edema Secondary to Diabetic Retinopathy
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: NOVA63035 "Corticosteroid"
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Relative Bioavailability of MN-166 (Ibudilast) in Extended Release Tablet vs. Intermediate-release Capsule in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: MN-166
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Of Alirocumab to Prevent Early Cardiac Allograft Vasculopathy in Recent Heart Transplant Recipients
Status: RECRUITING
Conditions: Cardiac Allograft Vasculopathy
Interventions: DRUG: Alirocumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NIPS to Identify High-risk Patients With ICD
Status: COMPLETED
Conditions: Malignant Arrhythmia
Interventions: PROCEDURE: Sustained or hemodynamically unstable arrhythmia induction during non-invasive programmed stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Dose Escalation and Proof-of-Concept Studies of Vactosertib (TEW-7197) Monotherapy in Patients With MDS
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: TEW-7197
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Lifestyle Modification on the Development of Dementia, Chronic Kidney Disease, Diabetes, Chronic Obstructive Pulmonary Disease, Cancers and Cardiovascular Disease in a Thai General Population
Status: ACTIVE_NOT_RECRUITING
Conditions: Dementia|Diabetes Mellitus|Chronic Kidney Disease|Cardiovascular Diseases|Malignancy|Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: 4 x 4 lifestyle modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fusion Status After ACDF
Status: ENROLLING_BY_INVITATION
Conditions: Spine Fusion|Spine Surgery
Interventions: PROCEDURE: Anterior Cervical Disc Fusion (ACDF) Surgery w/ machined bone allograft|PROCEDURE: Anterior Cervical Disc Fusion (ACDF) Surgery w/ Iliac Crest Bone Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Transcutaneous Electroacupuncture on Functional Abdominal Bloating/Distension
Status: UNKNOWN
Conditions: Functional Abdominal Bloating/Distension
Interventions: DEVICE: Transcutaneous Electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Whole Body Periodic Acceleration on Airway Endothelial Function
Status: COMPLETED
Conditions: Healthy|Smokers|Asthma
Interventions: DEVICE: Whole Body Periodic Acceleration (WBPA)|DEVICE: Sham WBPA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serial Advanced Magnetic Resonance Imaging Scan for Guidance of Personalized Adaptive Radiotherapy for High Grade Glioma
Status: RECRUITING
Conditions: Malignant Glioma
Interventions: PROCEDURE: Magnetic Resonance Imaging|OTHER: Neurocognitive Assessment|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Thalidomide Plus Interferon Alfa in Treating Patients With Progressive Liver Cancer That Cannot be Surgically Removed
Status: COMPLETED
Conditions: Liver Cancer
Interventions: BIOLOGICAL: recombinant interferon alfa|DRUG: thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of HYML-122 in Patients With FLT3 Positive Relapsed or Refractory Acute Myeloid Leukemia (AML)
Status: RECRUITING
Conditions: Relapsed or Refractory Acute Myeloid Leukemia (AML)
Interventions: DRUG: HYML-122
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Study (AtDvance) to Evaluate GSK1070806 in Atopic Dermatitis.
Status: NOT_YET_RECRUITING
Conditions: Dermatitis, Atopic
Interventions: DRUG: GSK1070806
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing 19 and 25G Needles for Fine Needle Aspiration (FNA) of Solid Pancreatic Mass Lesions Greater Than 35mm
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: PROCEDURE: biopsy with 19 gauge needle|PROCEDURE: biopsy with 25 gauge needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Preoxygenation With a High-flow Nasal Cannula or a Simple Mask Before General Anesthesia in Head and Neck Surgery
Status: COMPLETED
Conditions: Head and Neck Neoplasm
Interventions: DEVICE: High-flow nasal cannula|DEVICE: simple mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Ranging Placebo-controlled Double-blind Study to Evaluate the Safety, Pharmacokinetics and Efficacy of 610 in Participants With Severe Eosinophilic Asthma
Status: ACTIVE_NOT_RECRUITING
Conditions: Asthma
Interventions: DRUG: 610 30mg group|DRUG: 610 100mg group|DRUG: 610 300mg group|OTHER: Placebo 30mg group|OTHER: Placebo 100mg group|OTHER: Placebo 300mg group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Adductor Canal Block Using Liposomal Bupivacaine
Status: NOT_YET_RECRUITING
Conditions: Pain, Postoperative
Interventions: DRUG: Liposomal bupivacaine|DRUG: Bupivacaine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Better Sleep for Supporters With Insomnia Study
Status: COMPLETED
Conditions: Family Caregivers|Cancer|Insomnia|Sleep Initiation and Maintenance Disorders
Interventions: BEHAVIORAL: SHUTi (Sleep Healthy Using the Internet)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity, Safety and Tolerability of Two Doses of Adjuvanted and Non-adjuvanted Swine Origin A/H1N1 Monovalent Influenza Vaccine in Healthy Subjects 18 or More Years of Age
Status: COMPLETED
Conditions: Pandemic Influenza
Interventions: BIOLOGICAL: Monovalent A/H1N1 influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Application of HFNC for the Prevention of Hypoxemia During Perioperative Anesthetic-induced Intubation in Children: A Randomized Controlled Clinical Trial
Status: RECRUITING
Conditions: High-flow Nasal Cannula|Children|Pre-oxygenation
Interventions: DEVICE: high-flow nasal cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Changes in Weight, Body Composition and Cardiac Risk After Discontinuing Abacavir Treatment in HIV-infected Individuals
Status: COMPLETED
Conditions: Hiv|HIV Infections|HIV Cardiomyopathy|Weight Change, Body|HIV Lipodystrophy|Cardiovascular Diseases
Interventions: DRUG: Dolutegravir / Lamivudine Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Brominated and Organophosphate Flame Retardants and Type 2 Diabetes
Status: RECRUITING
Conditions: Type 2 Diabetes|Novel Brominated Flame Retardants|Organophosphate Flame Retardants|Fasting Plasma Glucose
Interventions: OTHER: no intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Relationship Between 18FDG PET/MRI Patterns and ctDNA to Predict HCC Recurrence After Liver Transplantation
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DEVICE: PET MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Konjac Glucomannan Noodle Intervention in Subjects With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Glucomannan noodle|DIETARY_SUPPLEMENT: Placebo noodle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Monosodium L-glutamate (MSG) on Satiety
Status: COMPLETED
Conditions: Nutrition Intervention
Interventions: DIETARY_SUPPLEMENT: Soup with MSG|DIETARY_SUPPLEMENT: Control soup no MSG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Efficacy and Safety of Anti-PD-1 Antibody AK105 in Patients With Selected Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor|Lung Cancer|HCC
Interventions: DRUG: AK105
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thalidomide in Treating Patients With Recurrent or Persistent Carcinosarcoma of the Uterus
Status: COMPLETED
Conditions: Recurrent Uterine Corpus Sarcoma|Uterine Carcinosarcoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tunneling Technique in Treatment of Miller's Class III Gingival Recession
Status: UNKNOWN
Conditions: Gingival Recession
Interventions: PROCEDURE: group A (Tunnel procedure with subepithelial connective tissue graft (sCTG)|PROCEDURE: group B (Tunnel procedure with modified free gingival graft (mFGG))
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase Ib, Single-arm Study of AZD6094 (Volitinib) in Combination With Docetaxel, in Any Solid Cancer and Sequential Phase II, Single-arm Study of AZD6094 (Volitinib) in Combination With Docetaxel in Advanced Gastric Adenocarcinoma Patients With MET Amplification as a Second Line Treatment
Status: COMPLETED
Conditions: Advanced Gastric Adenocarcinoma
Interventions: DRUG: AZD6094|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monitoring Glucose Levels in Patients With Myocardial Infarction
Status: TERMINATED
Conditions: Acute Coronary Syndromes|Hyperglycemia|Hypoglycemia
Interventions: DEVICE: OptiScanner®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Enhancing PrEP Outcomes Among Kenyan Adolescent Girls and Young Women With a Novel Pharmacy-based PrEP Delivery Platform
Status: RECRUITING
Conditions: Hiv
Interventions: BEHAVIORAL: Nurse-Navigator Enhanced PrEP Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Lysine-specific Demethylase 1 and Salt-sensitivity in Humans
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Subjects
Interventions: OTHER: Aldosterone response to AngII LS|OTHER: Renal blood flow response to salt|OTHER: Vascular Stiffness
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Collaborative Care to Reduce Depression and Increase Cancer Screening Among Low-Income Urban Women
Status: COMPLETED
Conditions: Depression|Breast Cancer Screening|Cervical Cancer Screening|Colorectal Cancer Screening
Interventions: BEHAVIORAL: Prevention Care Management for Depression and Cancer Screening|BEHAVIORAL: Prevention Care Management for Cancer Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ABSORB III Randomized Controlled Trial (RCT)
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Artery Stenosis|Coronary Disease|Coronary Stenosis
Interventions: DEVICE: Absorb BVS|DEVICE: XIENCE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Rehabilitation Robots-Morning Walk in Individuals With Hemiparesis
Status: RECRUITING
Conditions: Stroke|Healthy Volunteers
Interventions: BEHAVIORAL: Morning Walk training for stroke|BEHAVIORAL: Morning Walk training for healthy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of a New Treatment as Adjunctive Therapy to Anti-vascular Endothelial Growth Factor (Anti-VEGF) Treatment in Patients With Age-Related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Choroidal Neovascularization|Age-Related Maculopathy
Interventions: DRUG: dexamethasone|BIOLOGICAL: ranibizumab|OTHER: sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interrupted Versus Continuous Subcuticular Skin Suturing in Elective Cesarean Section.
Status: COMPLETED
Conditions: Cesarean Section Wound
Interventions: PROCEDURE: Interrupted subcuticular skin closure|PROCEDURE: continuous subcuticular skin closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of an Implanted Neuroprosthesis With Sensory Training for Improving Airway Protection in Chronic Dysphagia
Status: COMPLETED
Conditions: Chronic Dysphagia|Multiple Sclerosis|Parkinson Disease
Interventions: DEVICE: Neurostimulation device for dysphagia|DEVICE: External vibrotactile device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: PEMBRO With Chemo in Neo Adj Treatment of Ovarian Cancer .
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer Stage IV
Interventions: DRUG: Pembrolizumab Injectable Product - Chemotherapy - Bevacizumab|DRUG: Chemotherapy - Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BReast CAncer Genes(BRCA) Expressions in Metastatic Gastric Cancer
Status: COMPLETED
Conditions: BRCA Gene Rearrangement
Interventions: GENETIC: BRCA 1|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of FODMAPs in Upper GI Effects, Colonic Motor Activity and Gut-brain Signaling at the Behavioral Level
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: FODMAP|DIETARY_SUPPLEMENT: Glucose (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics and Oral Bio Availability of Veliparib in Subjects With Solid Tumors
Status: COMPLETED
Conditions: Oncology|BRCA Mutated|High Grade Serous Ovarian Cancer|BRCA Mutated Breast Cancer
Interventions: DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Relaxin for the Treatment of Acute Heart Failure
Status: COMPLETED
Conditions: Heart Failure, Congestive
Interventions: DRUG: Relaxin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Myocardial Fibrosis Identification in Patients With Anthracycline-induced Cardiotoxicity
Status: RECRUITING
Conditions: Cardiomyopathy Due to Drug
Interventions: DIAGNOSTIC_TEST: Evaluation of myocardial fibrosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Telmisartan in Hypertensive Patients With Mild/Moderate or Severe Renal Impairment or Requiring Hemodialysis
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan low dose|DRUG: Telmisartan high dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telephone-delivered Behavioral Interventions to Reduce Risky Sexual Behavior in HIV-positive Late Middle-age and Older Adults
Status: COMPLETED
Conditions: Unsafe Sex
Interventions: BEHAVIORAL: 1-session of telephone-administered motivational interviewing|BEHAVIORAL: 4-session telephone-administered motivational interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess Efficacy of Nutritional Therapy in Secondary Prophylaxis of Hepatic Encephalopathy Versus Lactulose in Patients With Liver Cirrhosis.
Status: WITHDRAWN
Conditions: Liver Cirrhosis
Interventions: DIETARY_SUPPLEMENT: Nutrition|DRUG: Lactulose|DIETARY_SUPPLEMENT: Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of Praliciguat (IW-1973) in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: IW-1973|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Misoprostol Versus Oxytocin for Prevention of Post Partum Hemorrhage
Status: COMPLETED
Conditions: Post Partum Hemorrhage
Interventions: DRUG: Misoprostol|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Safety and Efficacy of Brincidofovir in Treatment of Early Versus Late Adenovirus Infection
Status: COMPLETED
Conditions: Adenovirus Infection
Interventions: DRUG: Brincidofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Workshop for Primary Prevention of Falls. CHANGING TO NEVER FALL. CTNF
Status: UNKNOWN
Conditions: Dietary Habits|Accidental Falls|Unspecified Fall, Occurrence at Home|Physical Activity
Interventions: BEHAVIORAL: 3 session workshop|BEHAVIORAL: 1 session workshop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase II Study of Umbilical Cord Blood Transplantation
Status: TERMINATED
Conditions: Leukemia|Lymphoma|Multiple Myeloma|Aplastic Anemia
Interventions: BIOLOGICAL: Umbilical Cord Blood After Myeloablative Conditioning|BIOLOGICAL: Umbilical Cord Blood After Reduced-Intensity Conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BIIB033 Single Ascending Dose Study in Healthy Volunteer Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIIB033|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Embryo Culture Under a Continuous CO2 Setting Versus a Sequential CO2 Setting
Status: COMPLETED
Conditions: Infertility
Interventions: OTHER: Continuous CO2 Level
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of Multiple Overlapping Uncovered Stents for Pararenal Aortic Aneurysm Repair
Status: UNKNOWN
Conditions: Aortic Aneurysm|Aortic Aneurysm, Abdominal|Aortic Aneurysm, Thoracic|Aortic Aneurysm, Thoracoabdominal
Interventions: PROCEDURE: Multiple overlapping uncovered stents|DEVICE: Uncovered stents
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: THE EFFECT OF MULTIPLE DOSES OF PF-06835919 ON THE PHARMACOKINETICS OF A SINGLE ORAL MIDAZOLAM DOSE IN HEALTHY PARTICIPANTS
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: PF 06835919|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Mass Evaluation of Lateral Flow Immunoassays for the Detection of SARS-CoV-2 (Covid-19) Antibodies
Status: COMPLETED
Conditions: Solid Organ Transplant Recipients|Autoimmune Diseases|Haematological Malignancies
Interventions: DIAGNOSTIC_TEST: self-administered lateral flow assays
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study To Investigate The Absorption, Metabolism And Excretion Of [14C] PD 0200390 In Six Healthy Male Volunteers
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: PD 0200390
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Variability In Hearing Aid Outcomes In Older Adults
Status: COMPLETED
Conditions: Hearing Loss|Presbycusis
Interventions: DEVICE: Hearing Aid Fitting A|DEVICE: Hearing Aid Fitting B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Virtual Reality Exercise Gaming in Patients Awaiting Bariatric Surgery
Status: UNKNOWN
Conditions: Bariatric Surgery|Prehabilitation
Interventions: BEHAVIORAL: Exercise Prescription|DEVICE: Exercise Prescription and Virtual Reality Exercise Gaming support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Safety, Blood Levels and Brain Receptor Occupancy of GSK598809 Using PET Imaging in Health Males.
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: GSK598809, using [11C]-(+)-PHNO
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wise Interventions in the Digital Society
Status: COMPLETED
Conditions: Cyberbullying|Grooming|Risk Behavior
Interventions: BEHAVIORAL: Wise Intervention (Self-affirmation and Incremental theory of personality)|BEHAVIORAL: Standard preventive intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Sotatercept for the Treatment of Chemotherapy Induced Anemia in Patients With Metastatic Breast Cancer (MK-7962-012)
Status: TERMINATED
Conditions: Chemotherapy Induced Anemia
Interventions: BIOLOGICAL: Sotatercept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Evaluation of Non-Operative Treatments for Gastrocutaneous Fistulae in Children
Status: UNKNOWN
Conditions: Gastrocutaneous Fistula|Gastrostomy Complications
Interventions: DRUG: oral anti-acid treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Speckle Tracking and Inhaled Nitric Oxide in Acute Respiratory Distress Syndrome
Status: RECRUITING
Conditions: ARDS|Right Ventricle
Interventions: OTHER: TEE|OTHER: TTE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cocoa Ileostomy Study
Status: COMPLETED
Conditions: Ileostomy - Stoma
Interventions: DIETARY_SUPPLEMENT: Cocoa Flavanol beverage mix|DIETARY_SUPPLEMENT: De-xanthinated Cocoa Flavanol beverage mix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ablate and Pace HIS Study
Status: RECRUITING
Conditions: HIS Bundle Pacing|Atrial Fibrillation
Interventions: PROCEDURE: Ablation and Pacemaker Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Photobiomodulation Therapy in the Management of Chemotherapy-Induced Peripheral Neuropathy
Status: RECRUITING
Conditions: Chemotherapy-induced Peripheral Neuropathy
Interventions: DEVICE: Multiwave Locked System® (M6 laser, ASA srl, Arcugnano (VI), Italy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Pharmacodynamics Profile and Tolerance of P03277 in Healthy Subjects and Patients With Brain Lesions
Status: COMPLETED
Conditions: Healthy Volunteers|Brain Lesion
Interventions: DRUG: P03277|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Diagnostic Performance of a Novel Ferumoxytol-Enhanced Magnetic Resonance Angiography/ Venography on Panvascular Disease
Status: RECRUITING
Conditions: Panvascular Disease
Interventions: DIAGNOSTIC_TEST: Ferumoxytol Enhanced Magnetic Resonance Angiography（ FE-MRA）；Coronary/Renal /Lower artery Arteriography|DIAGNOSTIC_TEST: Ferumoxytol Enhanced Magnetic Resonance Venography（ FE-MRV）, Computed Tomography Pulmonary Angiography, Ultrasound for Lower Extremity Deep Vein.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: M7824 Versus Pembrolizumab as a First-line (1L) Treatment in Participants With Programmed Death-ligand 1 (PD-L1) Expressing Advanced Non-small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: M7824|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trauma Informed Intervention to Support Engagement in HIV Care Among MSM (THRIVE+)
Status: COMPLETED
Conditions: HIV/AIDS|Trauma
Interventions: BEHAVIORAL: CBT-TSC|BEHAVIORAL: Life Steps and Sexual Decision-Making
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of DKN-01 in Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer|Colorectal Adenocarcinoma|Colo-rectal Cancer|Colorectal Cancer Metastatic
Interventions: DRUG: DKN-01|DRUG: FOLFIRI|DRUG: Bevacizumab|DRUG: FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carboplatin/Paclitaxel + Pembrolizumab for Locoregionally Advanced Penile Cancer
Status: RECRUITING
Conditions: Urologic Neoplasms|Urogenital Neoplasms|Male Urogenital Diseases|Penile Cancer|Penile Squamous Cell Carcinoma|Locally Advanced Penile Carcinoma
Interventions: DRUG: Carboplatin/Paclitaxel|DRUG: Pembrolizumab|PROCEDURE: Partial or total penectomy with inguinal and/or pelvic lymph node dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Slow Wave Sleep as a Biomarker of Rehabilitation-induced Cognitive Improvement in PD
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: OTHER: Progressive Resistance Training (PRT)|OTHER: Delayed Exercise Training (DE)|OTHER: Endurance Training (ET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Study to Assess the Tolerability of Once Daily Lopinavir/Ritonavir (LPV/r) Liquid Versus Capsules
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: Different formulations of once-daily lopinavir/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction of Fibrosis Regression on Patients With Chronic Hepatitis B Infection
Status: TERMINATED
Conditions: Hepatitis B, Chronic|Liver Fibrosis
Interventions: DRUG: Treatment with entecavir(Baraclude®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: SX ELLA Esophageal Degradable BD Stent System
Status: COMPLETED
Conditions: Benign Esophageal Lesions
Interventions: DEVICE: Stenting with ELLA Biodegradable stent|PROCEDURE: Standard Dilations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Seladelpar in Subjects With Primary Biliary Cholangitis (PBC)
Status: RECRUITING
Conditions: Primary Biliary Cirrhosis
Interventions: DRUG: Seladelpar 5 mg Capsule|DRUG: Seladelpar 10 mg Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Influenza A Challenge Study Following Oral Administration of an H1N1 HA Ad-Vector Seasonal Flu Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: VXA-A1.1|BIOLOGICAL: Fluzone®|OTHER: Placebo Tablets|OTHER: Saline Solution for Placebo IM Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The MalaYsian GestatiOnal Diabetes and Prevention of DiabetES Study
Status: RECRUITING
Conditions: Gestational Diabetes|GDM|Pregnancy-Induced Diabetes
Interventions: OTHER: MyManis app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Guided Online ACT Intervention Combined With Psychoeducation for People With Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries|Psychological Distress
Interventions: BEHAVIORAL: acceptance and commitment therapy (ACT) combined with psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of OneTouch® Verio™IQ Meter
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: Verio Pattern Alert® activated|DEVICE: Verio Pattern Alert® deactivated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Remote Training in Laparoscopy
Status: COMPLETED
Conditions: Educational Problems|Surgery
Interventions: OTHER: Home-based self-regulated simulation training (SRST)|OTHER: Centralized instructor-regulated simulation training (IRST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Direct obserVed therApy vs fortNightly CollEction Study for HCV Treatment - ADVANCE HCV Study
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Elbasvir/Grazoprevir 50 MG-100 MG Oral Tablet|BEHAVIORAL: Psychological intervention|DRUG: Sofosbuvir 400 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short-term Effects of Good Metabolic Control on Cognitive Function, Wellbeing, and Metabolic Parameters in Adult Patients With Phenylketonuria
Status: TERMINATED
Conditions: Phenylketonurias
Interventions: OTHER: PHE-diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid Delivery of Autologous Bone Marrow Derived Stem Cells in Acute Myocardial Infarction Patients.
Status: UNKNOWN
Conditions: Acute Myocardial Infarction
Interventions: OTHER: Autologous Bone marrow mononuclear cells|OTHER: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zoledronic Acid in Treating Patients With Metastatic Breast Cancer, Metastatic Prostate Cancer, or Multiple Myeloma With Bone Involvement
Status: COMPLETED
Conditions: Breast Adenocarcinoma|DS Stage I Plasma Cell Myeloma|DS Stage II Plasma Cell Myeloma|Metastatic Malignant Neoplasm to the Bone|Pain|Musculoskeletal Complication|Urinary Complications
Interventions: DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Assess the Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of GW003 in Patients With Breast Cancer
Status: UNKNOWN
Conditions: Chemotherapy-induced Neutropenia
Interventions: BIOLOGICAL: Pegylated Recombinant Human G-CSF|BIOLOGICAL: GW003
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study Exploring the Effects on Cognition of Sertindole Versus Comparator in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Cognition
Interventions: DRUG: Sertindole|DRUG: Quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RElugolix VErsus LeUprolide Cardiac Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Biochemically Recurrent Prostate Carcinoma|Localized Prostate Carcinoma|Stage I Prostate Cancer AJCC v8|Stage II Prostate Cancer AJCC v8|Stage IIA Prostate Cancer AJCC v8|Stage IIB Prostate Cancer AJCC v8|Stage IIC Prostate Cancer AJCC v8|Stage III Prostate Cancer AJCC v8|Stage IIIA Prostate Cancer AJCC v8|Stage IIIB Prostate Cancer AJCC v8|Stage IIIC Prostate Cancer AJCC v8
Interventions: RADIATION: Radiation therapy|DRUG: Leuprolide|DRUG: Relugolix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Access to an EHR Patient Portal Influence Chronic Disease Outcomes?
Status: COMPLETED
Conditions: Congestive Heart Failure|Diabetes|Cardiovascular Disease
Interventions: PROCEDURE: Tailored Healthmedia programs on EHR Patient Portal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose:
Clinical trial: The Impact of Cigarette Smoking on Periodontal Therapy
Status: COMPLETED
Conditions: Periodontitis|Cigarette Smoking
Interventions: PROCEDURE: Non-surgical periodontal therapy: motivation and instruction in oral hygiene, debridement using handinstrumentation (Hu-Firedy,Chicago, IL, USA;and American Eagle Instruments,Missoula, MT,USA).
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment for Adductor Spasmodic Dysphonia by Type 2 Thyroplasty Using Titanium Bridges
Status: COMPLETED
Conditions: Adductor Spasmodic Dysphonia
Interventions: DEVICE: Type 2 Thyroplasty using Titanium Bridges
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Controlled Sedation for Cataract Surgery
Status: TERMINATED
Conditions: Failed Conscious Sedation During Procedure
Interventions: DRUG: remifentanil|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Immunomodulatory Effect of Sugammadex After Total Hip Replacement Surgery Under Neuraxial Anaesthesia: a Pilot Study
Status: COMPLETED
Conditions: Innate Inflammatory Response|Osteoarthritis, Hip
Interventions: DRUG: Sugammadex 100 MG/ML [Bridion]|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Safety Study of Ceftolozane/Tazobactam in Pediatric Participants Receiving Antibiotic Therapy for Proven or Suspected Gram-negative Infection or for Peri-operative Prophylaxis (MK-7625A-010)
Status: COMPLETED
Conditions: Proven or Suspected Gram-negative Bacterial Infection|Peri-operative Prophylaxis
Interventions: DRUG: Ceftolozane/Tazobactam 1000/500 mg|DRUG: Ceftolozane/Tazobactam 30/15 mg/kg|DRUG: Ceftolozane/Tazobactam 20/10 mg/kg|DRUG: Ceftolozane/Tazobactam 18/9 mg/kg|DRUG: Ceftolozane/Tazobactam 12/6 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Microbiology of Caries Resistance
Status: COMPLETED
Conditions: Dental Caries
Interventions: OTHER: Caries Free|OTHER: Caries Active|OTHER: Caries Free - Placebo|OTHER: Caries Active - Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Vitamin D Versus Placebo in the Treatment of Vague Musculoskeletal Pain in Children
Status: WITHDRAWN
Conditions: Hypovitaminosis D
Interventions: DIETARY_SUPPLEMENT: Vitamin D|OTHER: Placebo candy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of The Effects of Multiple Doses of Ketoconazole on Single Dose Pharmacokinetics of RO4602522 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: RO4602522|DRUG: ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Low-Intensity Focused Ultrasound Neuromodulation of the Mediodorsal Thalamus for Treatment-Resistant Schizophrenia
Status: SUSPENDED
Conditions: Treatment-resistant Schizophrenia
Interventions: DEVICE: Insightec Exablate Neuro MR-guided focused ultrasound transducer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Gemcitabine and Oxaliplatin for Triple Negative Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Gemcitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Photobiomodulation to Reduce Post-operative Pain After Endodontic Surgery
Status: NOT_YET_RECRUITING
Conditions: Photobiomodulation|Endodontic Disease|Pain|Inflammation|Surgery
Interventions: DRUG: Ibuprofen|OTHER: Photobiomodulation simulation|DEVICE: Photobiomodulation|OTHER: Ibuprofen simulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Breast Cancer, Reasoning, and Activity Intervention
Status: RECRUITING
Conditions: Breast Cancer|Breast Neoplasms|Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Cancer-related Cognitive Dysfunction
Interventions: BEHAVIORAL: Aerobic Exercise Training|OTHER: Health Education (Active comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Towards Telemonitoring in Immune-Mediated Inflammatory Diseases: Implementation of a Mixed Attention Model (IMIDOC)
Status: NOT_YET_RECRUITING
Conditions: Telemedicine|Telehealth|eHealth|Rheumatic Diseases|Arthritis, Rheumatoid|Spondylarthritis
Interventions: DEVICE: IMIDOC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Camrelizumab Combined Apatinib in Hepatocellular Carcinoma Previously Treated With Immune Checkpoint Inhibitors (ICIs).
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma|Immune Checkpoint Inhibitors
Interventions: DRUG: Camrelizumab combined Apatinib regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dextroamphetamine as Adjunct in Cocaine/Opiate Dependent Patients - 3
Status: COMPLETED
Conditions: Cocaine-Related Disorders|Opioid-Related Disorders
Interventions: DRUG: Dextroamphetamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Implementing a Low Fiber Diet vs. Regular Diet in Postoperative Colorectal Patients With Ileostomies
Status: RECRUITING
Conditions: Ileostomy; Complications|Bowel Obstruction|Postoperative Ileus
Interventions: BEHAVIORAL: Regular diet|BEHAVIORAL: Low fiber diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Investigation of Food Effect and Gastric ph Increase on the Bioavailability of Faldapravir
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: faldaprevir|DRUG: faldaprevir|DRUG: omeprazole|DRUG: faldaprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Clinical Trial to Evaluate the Immunogenicity and Safety of SCTV01C and SCTV01E in Population Aged ≥12 Years Previously Fully Vaccinated With Inactivated COVID-19 Vaccine
Status: UNKNOWN
Conditions: COVID-19|SARS-CoV-2 Infection
Interventions: BIOLOGICAL: SCTV01C|BIOLOGICAL: SCTV01E|BIOLOGICAL: Sinopharm inactivated COVID-19 vaccine|BIOLOGICAL: Comirnaty|BIOLOGICAL: SCTV01E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Surgical Pleth Index (SPI) Versus Standard Clinical Approach Analgesia
Status: UNKNOWN
Conditions: Anesthesia|Pain|Surgery
Interventions: DEVICE: Surgical Pleth Index|OTHER: Clinical guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of SQIN™ on Xerosis in Adults With Mobility Problems and Paralysis
Status: COMPLETED
Conditions: Xerosis
Interventions: OTHER: SQIN|OTHER: standard moisturizing cream (Glaxal Base)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Sedentary Behaviors at Work on Health in Emergency Medical Dispatchers and CODIS Operators (SECODIS)
Status: NOT_YET_RECRUITING
Conditions: Sedentary Behavior|Occupational Stress
Interventions: BEHAVIORAL: Control|BEHAVIORAL: Sit-and-stand desk|BEHAVIORAL: Cycloergometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Constraint-induced Movement Therapy (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegic Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Hemiplegia|Children|Pediatric
Interventions: PROCEDURE: Constraint-Induced Movement Therapy (CIMT)|PROCEDURE: Hand-Arm Bimanual Intensive Therapy (HABIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term, Follow-on Study of Lomitapide in Patients With Homozygous Familial Hypercholesterolemia
Status: COMPLETED
Conditions: Familial Hypercholesterolemia
Interventions: DRUG: lomitapide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intelligent Exercise and Ergonomic Recommendations on Surgeon Musculoskeletal Discomfort
Status: RECRUITING
Conditions: Occupational Injuries|Occupational Exposure
Interventions: BEHAVIORAL: Intelligent Physical Exercise Training (IPET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT