pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Assessing Inflammatory and Behavioral Pathways Linking PTSD to Increased Asthma Morbidity in WTC Workers
Status: COMPLETED
Conditions: Asthma|PTSD
Interventions: BEHAVIORAL: Cognitive Processing Therapy|BEHAVIORAL: Psychotherapy|BEHAVIORAL: Targeted Asthma Education|BEHAVIORAL: General Asthma Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Total-Body Irradiation Plus Stem Cell Transplantation And White Blood Cell Infusion in Treating Older Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: therapeutic allogeneic lymphocytes|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effects of SIMEOX on Flow and Volume in Healthy Subjects and Patients With COPD
Status: COMPLETED
Conditions: Healthy|Pulmonary Disease, Chronic Obstructive
Interventions: DEVICE: SIMEOX|DEVICE: PEP|OTHER: Spontaneous Exhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Decline in Asymptomatic Intracranial Stenosis Patients: A 1-Year Follow-Up Study
Status: RECRUITING
Conditions: Magnetic Resonance Imaging|Asymptomatic Intracranial Stenosis|Medical Treatment
Interventions: DRUG: Aspirin Tablet, Clopidogrel Bisulfate Tablets and Atorvastatin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability and Efficacy of Rapid Optimization, Helped by NT-proBNP testinG, of Heart Failure Therapies
Status: UNKNOWN
Conditions: Heart Failure
Interventions: OTHER: Usual Care|OTHER: High Intensity Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Innovating(IN) Shorter(S), All- Oral, Precised(P), Individualized(I) Treatment Regimen(RE) for Rifampicin Resistant Tuberculosis(INSPIRE-TB)
Status: RECRUITING
Conditions: Multidrug Resistant Tuberculosis
Interventions: OTHER: This is a non-intervention observational study.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Chemotherapy and Bone Marrow Transplantation or Peripheral Stem Cell Transplantation in Treating Patients With Oligodendroglioma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: BIOLOGICAL: filgrastim|DRUG: busulfan|DRUG: lomustine|DRUG: procarbazine hydrochloride|DRUG: thiotepa|DRUG: vincristine sulfate|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study to Identify Biomarkers of Hypoglycaemia in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus With Hypoglycemia
Interventions: DRUG: Humulin S
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Telmisartan Compared to Losartan + Hydrochlorothiazide in Patients With Mild-to-moderate Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan|DRUG: Losartan + Hydrochlorothiazide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bemarituzumab or Placebo Plus Chemotherapy in Gastric Cancers With Fibroblast Growth Factor Receptor 2b (FGFR2b) Overexpression
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Cancer|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Bemarituzumab|DRUG: mFOLFOX6|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Safety and Activity of Aldoxorubicin Plus Ifosfamide/Mesna in Subjects With Metastatic Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Metastatic, Locally Advanced, or Unresectable Soft Tissue Sarcoma
Interventions: DRUG: 170 mg/m2 aldoxorubicin|DRUG: 250 mg/m2 aldoxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UVA1 Light for Treatment of Scleroderma and Similar Conditions
Status: COMPLETED
Conditions: Scleroderma|Keloids|Other Fibrosing Conditions
Interventions: DEVICE: German manufactured UVA1 light emitting device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability Study of Infliximab in Juvenile Spondyloarthropathies
Status: COMPLETED
Conditions: Spondylarthropathies
Interventions: DRUG: infliximab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Episodic Future Thinking Intervention for Reducing Cigarette Consumption in Cigarette Smokers
Status: RECRUITING
Conditions: Cigarette Smoking-Related Carcinoma
Interventions: BEHAVIORAL: Smoking Cessation Intervention|BEHAVIORAL: Smoking Cessation Intervention (control)|OTHER: Medical Device Usage and Evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Predictive Value of the Insulin-like Growth Factor-1 (IGF-1) Generation Test for the Growth Response to Growth Hormone Treatment (PRED-IGF)
Status: WITHDRAWN
Conditions: Idiopathic Short Stature
Interventions: DRUG: Nutropin [Somatropin (rDNA origin) for injection]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rivastigmine for Intensive Care Unit (ICU) Delirium
Status: TERMINATED
Conditions: Delirium
Interventions: DRUG: Rivastigmine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Home-based Cardiac Rehabilitation With Comprehensive Centre-based Cardiac Rehabilitation in Patients Older Than 65 Years With Coronary Heart Disease. The HOMEBASE Trial
Status: UNKNOWN
Conditions: Coronary Heart Disease
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Randomized Control Trial of a Responsive Parenting Intervention to Support Healthy Brain Development and Self-regulation in Toddlers Born Preterm
Status: RECRUITING
Conditions: Premature Birth
Interventions: BEHAVIORAL: PALS intervention condition|BEHAVIORAL: Control condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study in Participants With Diabetic Kidney Disease
Status: TERMINATED
Conditions: Diabetic Kidney Disease|Diabetic Nephropathy|Diabetic Glomerulosclerosis
Interventions: DRUG: LY2382770|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: hOKT3gamma1 (Ala-Ala) for the Prevention of Human Islet Allograft Failure
Status: UNKNOWN
Conditions: Diabetes Mellitus, Insulin-Dependent|Diabetes Mellitus, Experimental|Transplantation, Homologous|Islets of Langerhans Transplantation
Interventions: DRUG: hOKT3gamma1 (Ala-ala)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Association of Two Desensitizing Protocols to Control Dentinal Hypersensitivity in Non-carious Lesions
Status: COMPLETED
Conditions: Dental Hypersensitivity
Interventions: OTHER: Photon Laser III-DMC (without radiation emission) + My First- Colgate|OTHER: Photon Laser III-DMC (without radiation emission) + Sensodyne® Rapid Relief / GSK|RADIATION: Photon Laser III-DMC (with irradiation emission) + My First- Colgate|COMBINATION_PRODUCT: Photon Laser III-DMC (with irradiation emission) +Sensodyne® Rapid Relief / GSK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Infant Formula With Probiotics on Infants Health
Status: COMPLETED
Conditions: Probiotics Infant Formula|Infants Health
Interventions: OTHER: Probiotic A formula|OTHER: Probiotic B formula|OTHER: Regular formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Amino Acid/Electrolyte-based Beverages on Hydration Status
Status: COMPLETED
Conditions: Dehydration
Interventions: OTHER: Distilled water|OTHER: Medical Food 1|OTHER: Medical Food 2|OTHER: Pedialyte|OTHER: Gatorade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Enhancing Radioiodine Incorporation Into BRAF Mutant Thyroid Cancers With the Combination of Vemurafenib and KTN3379
Status: COMPLETED
Conditions: Thyroid Cancer
Interventions: BIOLOGICAL: KTN3379|DRUG: vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Evaluation of Azidothymidine (AZT) in Children With Acquired Immune Deficiency Syndrome (AIDS) or AIDS Related Complex (ARC)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antiplatelet Strategy for Peripheral Arterial Interventions for Revascularization of Lower Extremities
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DRUG: Clopidogrel|DRUG: Acetylsalicylic acid (ASA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of the GI and II Values of Soft Drink and Soft Drink With Sugardown™
Status: COMPLETED
Conditions: Postprandial Hyperglycemia
Interventions: DIETARY_SUPPLEMENT: Sugardown™|DIETARY_SUPPLEMENT: Soft drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Immunotherapy With Nivolumab in Combination With Lenvatinib for Advanced Stage Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DRUG: Lenvatinib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Campath-1H Induction to Allow Discontinuation of Calcineurin Inhibitors After Renal Transplantation
Status: COMPLETED
Conditions: Primary Renal Transplant
Interventions: DRUG: Calcineurin inhibitor withdrawal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lifestyle and Pharmacological Interventions in Hypertrophic Cardiomyopathy
Status: COMPLETED
Conditions: Hypertrophic Cardiomyopathy
Interventions: DRUG: Sacubitril/Valsartan|BEHAVIORAL: Lifestyle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bedside Bone Biopsy in Diabetic Foot Osteomyelitis
Status: RECRUITING
Conditions: Subjects With Diabetes and DFU With a Suspicion of DFO
Interventions: PROCEDURE: Bedside blind bone biopsy procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Irinotecan Plus Lenalidomide in Adult Patients With Recurrent Glioblastoma Multiforme: Phase I
Status: TERMINATED
Conditions: Malignant Gliomas
Interventions: DRUG: Irinotecan|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Passive Fit of CAD/CAM Screw-retained Metal Frameworks Versus Screwmented Ones
Status: UNKNOWN
Conditions: Edentulous|Jaw
Interventions: PROCEDURE: Digitally constructed frameworks before implant placement|PROCEDURE: Digitally constructed frameworks after implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Retinitis Pigmentosa Via Combination of Wharton's Jelly-derived Mesenchymal Stem Cells and Magnovision
Status: COMPLETED
Conditions: Retinitis Pigmentosa
Interventions: BIOLOGICAL: Wharton's jelly derived mesenchymal stemcells|DEVICE: Magnovision
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CCI-779 and EKB-569 in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: pelitinib|DRUG: temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sulfonylurea Effects on Glucagon Regulation During Hypoglycemia in Type 1 DM
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: glibenclamide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Enzalutamide and Niraparib in the Treatment of Metastatic Castrate-Resistant Prostate Cancer (CRPC)
Status: TERMINATED
Conditions: Metastatic Prostate Cancer
Interventions: DRUG: Enzalutamide|DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing the Risk of Metabolic Decompensation in Diabetic Adolescents by Supervised School Administration of Insulin
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Insulin Degludec|DRUG: Insulin Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Which Supraesophageal Reflux Symptoms Reliably Respond to Proton-Pump-Inhibitor (PPI) Therapy
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: Nexium|DRUG: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Subsequent Treatment With the Zevalin (Ibritumomab Tiuxetan) Study in Patients With Follicular Grade I-II Lymphoma After 4 Cycles of Fludarabine-Mitoxantrone-Rituximab (FMR) Therapy
Status: COMPLETED
Conditions: Follicular Lymphoma
Interventions: DRUG: FM+R|DRUG: Zevalin (Ibritumomab Tiuxetan)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neostigmine and Dexamethasone in Adductor Canal Block
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Dexamethasone|DRUG: neostigmine|OTHER: NaCl solutions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Recombinant Human Interferon α-2b Spray on Herpangina
Status: COMPLETED
Conditions: Herpangina
Interventions: DRUG: Recombinant Human Interferon α-2b Spray|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Exposure and Activity of SAR341402 Mix 70/30 to NovoLog Mix 70/30, NovoMix 30 and SAR341402 Rapid-acting Solution in Patients With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: SAR341402|DRUG: Insulin Aspart|DRUG: Insulin Aspart|DRUG: SAR341402
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fish Oil Supplementation, Resting Energy Expenditure, Skeletal Muscle Membrane Composition and Metabolism in Elderly Subjects.
Status: UNKNOWN
Conditions: Whole Body and Skeletal Muscle Energy Metabolism
Interventions: DIETARY_SUPPLEMENT: Omega-3 Complete|DIETARY_SUPPLEMENT: Placebo Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Ultrasound Guided Genicular Nerve Block for Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Ultrasound guided genicular nerve block + exercise treatment|DEVICE: Physical therapy + exercise treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paired Assessment of Two Electromyographic Neuromuscular Monitors: Stimpod NMX450X Versus Datex-Ohmeda E-NMT
Status: RECRUITING
Conditions: Neuromuscular Manifestations
Interventions: DEVICE: EMG TOF device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: R-MACLO-IVAM and Thalidomide in Untreated Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Doxorubicin|DRUG: Etoposide|DRUG: Ifosfamide|DRUG: Leucovorin|DRUG: Methotrexate|DRUG: Thalidomide|DRUG: Vincristine|DRUG: Mesna|DRUG: Filgrastim (G-CSF)|DRUG: Granisetron|DRUG: Decadron
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preference of Women With Recurrent Urinary Tract Infection for Vaginal Estradiol Tablet vs Cream
Status: RECRUITING
Conditions: Recurrent Urinary Tract Infection
Interventions: DRUG: Estradiol vaginal cream|DRUG: Estradiol Vaginal Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Sarcoma
Status: COMPLETED
Conditions: Sarcoma
Interventions: BIOLOGICAL: filgrastim|DRUG: cisplatin|DRUG: doxorubicin hydrochloride|DRUG: ifosfamide|DRUG: melphalan|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2b Multicenter, Randomized, Double-Blind, Placebo- and Active-Controlled, Parallel-Group Study to Assess the PD Response and Safety of Three Dose Levels of (PB1023) Injection Following 20 Weeks of Weekly SC Dosing in Adults With T2DM
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: 50 mg PB1023|DRUG: 70 mg PB1023|DRUG: 100 mg PB1023|DRUG: Placebo (0.9% Sodium Chloride)|DRUG: Victoza®|OTHER: Diet and Exercise|DRUG: Metformin|DRUG: Sulfonylurea|DRUG: Metformin and Sulfonylurea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Single Dose Pharmacokinetics and Tolerability of Sativex in Patients With Impaired Hepatic Function and Healthy Patients
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: Sativex
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eslicarbazepine Acetate (BIA 2-093) as Monotherapy in Patients With Newly Diagnosed Partial-onset Seizures
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: ESL 800 mg|DRUG: ESL 1200 mg|DRUG: ESL 1600 mg|DRUG: ESL 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CMAP Plus Intervention for Self-harm in Individuals With Substance Use Disorder in Pakistan
Status: NOT_YET_RECRUITING
Conditions: Self Harm|Substance-Related Disorders
Interventions: BEHAVIORAL: CMAP Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise Training and Thrombotic Risk in Post-menopausal Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Thrombosis|Menopause|Exercise Training|Vascular Dilation
Interventions: OTHER: Early and late postmenopausal women
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Fasting on Patient Outcomes After Wide-Awake, Local Anesthesia-only, No Tourniquet (WALANT) Procedures
Status: RECRUITING
Conditions: Surgery|Anesthesia, Local|Fasting
Interventions: OTHER: Non-fasting|OTHER: Fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib/II Clinical Trial of PE0116 and PE0105 Injection in Treatment of Patients With Advanced Solid Tumor
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: PE0116,PE0105
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Prebiotic and Probiotic Dietary Modulation in Schizophrenic Disorders
Status: COMPLETED
Conditions: Schizophrenia and Related Disorders|Diet Habit
Interventions: BEHAVIORAL: Conventional Dietary Advice|BEHAVIORAL: Prebiotic/Probiotic Dietary Modulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration
Status: ACTIVE_NOT_RECRUITING
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: Faricimab|OTHER: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The VENUS Clinical Study (Verifying the Effectiveness of the NUsurface® System)
Status: COMPLETED
Conditions: Meniscectomy|Osteoarthritis
Interventions: DEVICE: NUsurface® Meniscus Implant|DRUG: NSAID's and Non-surgical Treatment Options|DRUG: Intra-Articular Injections with Corticosteroids|DRUG: Intra-Articular Injections with Hyaluronic Acid (HA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Usefulness of DORNASE in COVID-19 on HFNO
Status: TERMINATED
Conditions: COVID-19 Pneumonia
Interventions: DRUG: Dornase Alfa|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irreversible Electroporation(IRE) For Unresectable Esophageal Neoplasms
Status: COMPLETED
Conditions: Esophageal Neoplasms
Interventions: PROCEDURE: Irreversible electroporation (IRE)|DEVICE: NanoKnife
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interventional Validation of an MDS-Specific Measure of Quality of Life: Assessing the Responsiveness of the Quality of Life in Myelodysplasia Scale (QUALMS-1) to Different Hypomethylating Agent Regimens for Low and Intermediate Risk Disease
Status: COMPLETED
Conditions: Leukemia
Interventions: BEHAVIORAL: QUALMS-1 Questionnaire|BEHAVIORAL: FACT-An Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Rivaroxaban in the Early Postoperative Period for Patients With Bioprosthetic Valves
Status: NOT_YET_RECRUITING
Conditions: Anticoagulation
Interventions: DRUG: Rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of the Safety and Effectiveness of Motiva Implants®
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Implants
Interventions: DEVICE: Silicone gel-filled breast implants - Motiva Implants® Investigational breast implants
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study
Status: COMPLETED
Conditions: Corneal Neovascularisation|Keratoconus
Interventions: DEVICE: Optical Coherence Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Management of Myocardial Injury After Noncardiac Surgery Trial
Status: COMPLETED
Conditions: Myocardial Injury After Noncardiac Surgery (MINS)
Interventions: DRUG: Dabigatran|DRUG: Placebo (for Dabigatran)|DRUG: Omeprazole|DRUG: Placebo (for Omeprazole)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Double Mesh Modification of Incisional Hernia Can be Effective Without Severe Local Complications
Status: COMPLETED
Conditions: Incisional Hernia of Midline of Upper Abdomen|Incisional Hernia of Midline of Lower Abdomen|Incisional Hernia of Midline of Abdomen
Interventions: PROCEDURE: double mesh hernioplasty with modified chevrel's technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Internet-Based Interventions to Reduce Sexual Risk Among Men Who Have Sex With Men
Status: UNKNOWN
Conditions: HIV Infections
Interventions: BEHAVIORAL: Standard Text-Based Prevention Web Page|BEHAVIORAL: The Morning After|BEHAVIORAL: Talking About HIV|BEHAVIORAL: Both Videos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Patient Selection Using MR With Non-Perfusion Imaging for Endovascular Treatment Within 6 to 24 Hours
Status: RECRUITING
Conditions: Endovascular Thrombectomy
Interventions: PROCEDURE: Endovascular|DRUG: Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: PD 0360324 and Cyclophosphamide in Treating Patients With Recurrent High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
Status: WITHDRAWN
Conditions: Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma
Interventions: BIOLOGICAL: Anti-CSF1 Monoclonal Antibody PD-0360324|DRUG: Cyclophosphamide|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioural Group Therapy Versus Individual Supportive Therapy for the Prevention of Repeat Suicide Attempts
Status: RECRUITING
Conditions: Suicidal Ideation|Suicide, Attempt
Interventions: OTHER: Baseline evaluation with a psychiatrist|OTHER: Individual supportive therapy|OTHER: Cognitive behavioural group therapy|OTHER: Evaluations with a psychiatrist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prognostic Study of Metastases in Patients With Stage I, Stage II, or Stage III Non-small Cell Lung Cancer That Can Be Removed by Surgery
Status: COMPLETED
Conditions: Lung Cancer
Interventions: OTHER: immunohistochemistry staining method|PROCEDURE: biopsy|PROCEDURE: surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.
Status: RECRUITING
Conditions: Headache|Migraine With Aura|Migraine Without Aura
Interventions: DRUG: Levcromakalim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of a TauroLock™ Based Regimen to 4% Citrate as Lock Solution in Tunneled Haemodialysis Catheters for the Prevention of Bacteraemia and Dysfunction
Status: COMPLETED
Conditions: Catheter Infections|End-stage Renal Disease
Interventions: DEVICE: 4% citrate lock solution regimen|DEVICE: TauroLock lock solution regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Antifibrotic Therapy on Regression of Myocardial Fibrosis After Transcatheter Aortic Valve Implantation (TAVI) in Aortic Stenosis Patients With High Fibrotic Burden
Status: RECRUITING
Conditions: Aortic Stenosis, Severe
Interventions: OTHER: Standard of Care|DRUG: Spironolactone 25mg|DRUG: Dihydralazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Profiling of Pembrolizumab and Nivolumab in Patients With Melanoma and/or Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Non-Small Cell Carcinoma|Melanoma
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Electronic Health Record Review|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Magnesium Sulphate Versus Ketamine as an Adjuvant to Bupivacaine in Pectoral Nerve Block During Mastectomy
Status: NOT_YET_RECRUITING
Conditions: Cancer|Breast
Interventions: DRUG: Use of Bupivacaine in pectoral nerve block in mastectomy|DRUG: use of Ketamine as adjuvants to bupivacaine in pectoral nerve block in mastectomy|DRUG: Use of Magnesium Sulfate as adjuvants to bupivacaine in pectoral nerve block in mastectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Photobiomodulation in Temporomandibular Disorder
Status: UNKNOWN
Conditions: Pain|Temporomandibular Disorder
Interventions: DEVICE: Low-intensity laser|DEVICE: occlusal plates|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of the Antitumor Activity of Capecitabine in Combination With Erlotinib in Patients With Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Erlotinib and capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diuretic and Natriuretic Effect of High-dose Spironolactone in Patients With Acute Heart Failure
Status: UNKNOWN
Conditions: Heart Failure Acute|Heart Failure; With Decompensation
Interventions: DRUG: Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perineuraxial Anesthesia Fluid Management and Infant Neurobehaviors
Status: COMPLETED
Conditions: Cesarean Section
Interventions: DRUG: Ringer's Lactate|DRUG: Six percent hydroxyethyl starch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Venlafaxine Hydrochloride 150 mg Extended-Release Capsules Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Venlafaxine Hydrochloride|DRUG: Effexor® XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Safety and Pharmacokinetics of Multiple Dose of YC-6 in Healthy Subjects
Status: UNKNOWN
Conditions: Ischemic Stroke
Interventions: DRUG: YC-6|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reversible Cerebral Vasoconstriction Syndrome and Varicella Zoster Virus
Status: UNKNOWN
Conditions: Reversible Cerebral Vasoconstriction Syndrome|Varicella-zoster Virus Infection
Interventions: DIAGNOSTIC_TEST: VZV-specific antibody response from blood
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: NRX100 vs. Placebo for Rapid Stabilization of Acute Suicidal Ideation and Behavior in Bipolar Depression
Status: ACTIVE_NOT_RECRUITING
Conditions: Bipolar Depression|Suicidal Ideation
Interventions: DRUG: Ketamine Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of an Intranasal RSV Vaccine Expressing SARS-CoV-2 Spike Protein (COVID-19 Vaccine) in Adults
Status: UNKNOWN
Conditions: Covid19
Interventions: BIOLOGICAL: Investigational vaccine against SARS-CoV-2 [MV-014-212] Dosage 1, Single Dose, Intranasal Drops|BIOLOGICAL: Investigational vaccine against SARS-CoV-2 [MV-014-212] Dosage 2, Single Dose, Intranasal Drops|BIOLOGICAL: Investigational vaccine against SARS-CoV-2 [MV-014-212] Dosage 3, Single Dose, Intranasal Drops|BIOLOGICAL: Investigational vaccine against SARS-CoV-2 [MV-014-212] Dosage 3, Two Doses, Intranasal Drops|BIOLOGICAL: Investigational vaccine against SARS-CoV-2 [MV-014-212] Dosage 3, Single Dose, Intranasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial of Open Label Dipyridamole- In Hospitalized Patients With COVID-19
Status: TERMINATED
Conditions: COVID-19 Pneumonia|Vascular Complications
Interventions: DRUG: Placebo|DRUG: Dipyridamole Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Slow Expiratory Technique to Improve Alimentation in Children With Bronchiolitis
Status: COMPLETED
Conditions: Acute Viral Bronchiolitis
Interventions: OTHER: Chest physiotherapy with SET|OTHER: Standard Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Eltrombopag Post HSCT in BMFS
Status: RECRUITING
Conditions: Stem Cell Transplant Complications
Interventions: DRUG: Eltrombopag 25 MG Oral Tablet|DRUG: Supportive care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Epigenetic Evaluation of HAT/HDAC Activity in PBMC From Patients With Clinically Isolated Syndrome
Status: UNKNOWN
Conditions: Demyelinating Autoimmune Diseases, CNS
Interventions: BIOLOGICAL: blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: 28 Day Repeat Dose in Cystic Fibrosis Patients
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: SB656933|DRUG: SB656933|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Developing Biomarkers of Dietary Intake: Dose Dependent Measurement of Sugar Intake
Status: RECRUITING
Conditions: Diet Therapy|Healthy Volunteers
Interventions: BEHAVIORAL: Diet with no soda|BEHAVIORAL: Diet with 50% of carb intake from soda|BEHAVIORAL: Diet with 20% of carb intake from soda
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficiency and Safety of Pleural Biopsy Methods in the Diagnosis of Pleural Diseases
Status: COMPLETED
Conditions: Diagnosis of Pleural Diseases|Medical Thoracoscopy
Interventions: DIAGNOSTIC_TEST: CT-guided Abrams needle biopsy, US-guided cutting needle, medical thoracoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Tocilizumab for Cytokine Release Syndrome Prophylaxis in Haploidentical Transplantation
Status: COMPLETED
Conditions: Cytokine Release Syndrome|Stem Cell Transplant Complications
Interventions: DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Manual Therapy vs Exercises With Foam Rolling for Tension Headache
Status: COMPLETED
Conditions: Tension-type Headache
Interventions: OTHER: Manual Therapy protocol|OTHER: Foam Rolling protocol|OTHER: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Phase 1/2 Study to Evaluate ALN-KHK in Overweight to Obese Healthy Volunteers and Obese Patients With T2DM
Status: RECRUITING
Conditions: Type 2 Diabetes Mellitus (T2DM)
Interventions: DRUG: ALN-KHK|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Probiotics on Peripheral Immunity in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: DIETARY_SUPPLEMENT: Probiotics|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Erlotinib + Bevacizumab for PS 2 Chemotherapy Naïve Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Erlotinib|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMA901 in Patients Receiving Sunitinib for Advanced/Metastatic Renal Cell Carcinoma
Status: COMPLETED
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: Sunitinib|BIOLOGICAL: GM-CSF|DRUG: Cyclophosphamide|DRUG: IMA901
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heated Humidified High Flow Nasal Cannula Oxygen in Obstructive Sleep Apnea in Adolescents
Status: COMPLETED
Conditions: Obesity|Obstructive Sleep Apnea (Moderate to Severe)|Central Sleep Apnea
Interventions: OTHER: HHF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Silicone Gel vs. Estrogen Vaginal Cream for the Management of Genitourinary Syndrome of Menopause
Status: RECRUITING
Conditions: Genitourinary Syndrome of Menopause
Interventions: DEVICE: StrataMGT|DRUG: Estrace 0.01% Vaginal Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Heterologous Prime-boost of Recombinant COVID-19 Vaccine (Ad5 Vector) and RBD-based Protein Subunit Vaccine
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: recombinant Ad5 vectored COVID-19 vaccine|BIOLOGICAL: RBD-based protein subunit vaccine (ZF2001) against COVID-19|BIOLOGICAL: trivalent split influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I/II Trial of S65487 Plus Azacitidine in Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: S65487 and azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Mixture Myoinositol:D-chiro-inositol 3.6:1 in Women With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovarian Syndrome|Infertility
Interventions: DRUG: D-chiro-inositol|DRUG: Myoinositol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TRUDI: TDXD+Durva in HER2+/low IBC
Status: RECRUITING
Conditions: Invasive Breast Cancer|Inflammatory Breast Cancer Stage III|HER2-positive Breast Cancer|HER2 Low Breast Adenocarcinoma|Breast Cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesia for Fractured Neck of Femur With Periarticular Infiltration of Local Anaesthetic
Status: COMPLETED
Conditions: Fractured Neck of Femur|Postoperative Pain
Interventions: DRUG: Levobupivacaine infiltration group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BRSR: Feasibility and Acceptability Pilot
Status: RECRUITING
Conditions: Psychosocial Functioning|Surgery|Older Adults|Physical Function|Postoperative Outcome|Depressive Symptoms
Interventions: BEHAVIORAL: Problem Solving Therapy (PST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Anesthesia on Cerebral Perfusion in Patients With High Blood Pressure
Status: COMPLETED
Conditions: Lumbar Disc Disease|Lumbar Spinal Stenosis|Lumbar Disc Herniation|Lumbar Fracture
Interventions: PROCEDURE: normotensive patients|PROCEDURE: patients with hypertension diagnosis|PROCEDURE: patients who do not know they are hypertensive but actual blood pressure is high
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Comparison Trial of OPA-15406 Ointment in Pediatric Patients With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: 0.3% OPA-15406|DRUG: 1% OPA-15406|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Study to Assess Efficacy, Safety and Tolerability of LAS100977 in Asthmatic Patients.
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: LAS100977 0.313 μg|DRUG: LAS100977 0.625 μg|DRUG: LAS100977 1.25 μg|DRUG: LAS100977 2.5 μg|DRUG: Salbutamol 400 μg|DRUG: Salbutamol placebo|DRUG: LAS100977 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise in Patients With Hypermobile Joints and Knee Pain
Status: RECRUITING
Conditions: Hypermobility, Joint|Hypermobility Syndrome|Knee Discomfort
Interventions: OTHER: Neuromuscular training for the knee|OTHER: High-load strength training for the knee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Recurrent or Progressive Glioblastoma
Status: TERMINATED
Conditions: Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Recurrent Adult Brain Tumor
Interventions: DRUG: gamma-secretase/Notch signalling pathway inhibitor RO4929097|PROCEDURE: therapeutic conventional surgery|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adherence to Guidelines VAccination in Type 1 DIabetes Mellitus Patients (AVADI-2)
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: BIOLOGICAL: Covid-19 vaccination|BIOLOGICAL: Influenza vaccination|BIOLOGICAL: Pneumococal vaccination|BIOLOGICAL: Hepatitis B Virus (HBV) vaccination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT-389949 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: ACT-389949 40 mg|DRUG: ACT-389949 200 mg|DRUG: ACT-389949 800 mg|DRUG: ACT-389949 (Group C1 dose to be selected)|DRUG: ACT-389949 (Group C2 dose to be selected)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Xarelto on Prevention of Stroke and Non-Central Nervous Systemic Embolism in Renally Impaired Korean Patients With Non-valvular Atrial Fibrillation
Status: COMPLETED
Conditions: Non-valvular Atrial Fibrillation (NVAF)
Interventions: DRUG: Rivaroxaban(Xarelto,BAY 59-7939)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Conjunctival Autograft or Limbal Conjunctival Autograft for Recurrent Pterygium Using Mitomycin C
Status: UNKNOWN
Conditions: Recurrent Pterygium
Interventions: PROCEDURE: Pterygium excision|PROCEDURE: Intraoperative mitomycin C|PROCEDURE: Conjunctival autograft|PROCEDURE: Limbal conjunctival autograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT