pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Lymphodepletion Plus Adoptive Cell Transfer With or Without Dendritic Cell Immunization in Patients With Metastatic Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: BIOLOGICAL: Dendritic Cell Immunization|DRUG: Cyclophosphamide|DRUG: Fludarabine|BIOLOGICAL: T-Cells|BIOLOGICAL: Interleukin-2|DRUG: Mesna|BIOLOGICAL: Intrathecal T-Cells|BIOLOGICAL: Intrathecal Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pirfenidone Plus MODD in Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: DRUG: Pirfenidone with MODD|DRUG: Ketanserin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: First Line Metastatic Pancreatic Cancer : 5FU/LV+Nal-IRI, Gemcitabine+Nab-paclitaxel or a Sequential Regimen of 2 Months 5FU/LV+Nal-IRI
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Irinotecan Liposomal Injection|DRUG: 5-FU/LV|DRUG: Nab-Paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BAY58-2667 Dose Finding Trial Investigating Fixed Doses in Patients With Acute Decompensated Chronic Congestive Heart Failure (ADHF)
Status: TERMINATED
Conditions: Acute Heart Failure
Interventions: DRUG: Cinaciguat (BAY58-2667)|DRUG: Cinaciguat (BAY58-2667)|DRUG: Cinaciguat (BAY58-2667)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardio-Metabolic Risk Evaluation in Overweight and Obese Children
Status: NOT_YET_RECRUITING
Conditions: Pediatric Obesity|Metabolic Syndrome|Nonalcoholic Fatty Liver|Atherosclerosis|Psychology|Cardiometabolic Syndrome
Interventions: OTHER: History and Clinical evaluation|DIAGNOSTIC_TEST: Biological evaluation of the metabolic syndrome and components|DIAGNOSTIC_TEST: Ultrasound evaluation of subclinical atherosclerosis and visceral fat storage|OTHER: Nutritional assessment|BEHAVIORAL: Psychological evaluation of the impact of obesity/overweight
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of GSK Biologicals' Non-typeable Haemophilus Influenzae (NTHi) Investigational Vaccine (GSK2838497A) in Current and Former Smokers
Status: COMPLETED
Conditions: Respiratory Disorders
Interventions: BIOLOGICAL: NTHI vaccine GSK2838500A (formulation 1)|BIOLOGICAL: NTHI vaccine GSK2838501A (formulation 2)|BIOLOGICAL: NTHI vaccine GSK2838502A (formulation 3)|BIOLOGICAL: NTHI vaccine GSK2838503A (formulation 4)|BIOLOGICAL: NTHI vaccine GSK2838504A (formulation 5)|BIOLOGICAL: NTHI vaccine GSK2838505A (formulation 6)|BIOLOGICAL: NTHI vaccine GSK2838508A (formulation 7)|BIOLOGICAL: NTHI vaccine GSK2838509A (formulation 8)|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Yield of Cryoprobe vs Flexible Forceps Pleural Biopsy
Status: COMPLETED
Conditions: Pleural Effusion|Pleurisy|Tuberculosis|Metastatic Malignancy
Interventions: DEVICE: Cryoprobe pleural biopsy first|DEVICE: Flexible forceps biopsy first
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Pilocarpine in Patients With Xerostomia
Status: UNKNOWN
Conditions: Xerostomia
Interventions: DRUG: Pilocarpine|OTHER: Spray without Pilocarpine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sizing-sTrategy of Bicuspid AoRtic Valve Stenosis With Transcatheter Self-expandable Valve
Status: UNKNOWN
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: Down sizing valve in type-0 BAS|DEVICE: Standard sizing valve in type-0 BAS|DEVICE: Standard sizing valve in TAS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Resynchronisation Therapy In Patients With Heart Failure: Mechanistic Insights From Cardiac MRI And Electroanatomical Mapping
Status: UNKNOWN
Conditions: Heart Failure
Interventions: PROCEDURE: Temporary pacing Study|RADIATION: Thoracic CT|DIAGNOSTIC_TEST: Acute hemodynamic study|DIAGNOSTIC_TEST: Non-invasive body surface mapping|DIAGNOSTIC_TEST: Invasive catheter-based mapping
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MK-6913 for the Treatment of Hot Flashes in Postmenopausal Women (6913-004)
Status: TERMINATED
Conditions: Moderate to Severe Vasomotor Symptoms in Postmenopausal|Women
Interventions: DRUG: MK-6913|DRUG: 17-β estradiol|DRUG: Placebo to MK-6913|DRUG: Placebo to 17-β estradiol|DRUG: MK-6913 25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of a Pharmaceutical Care Model in the Management of Chronic Myeloid Leukemia Patients
Status: COMPLETED
Conditions: Leukemia, Myelogenous, Chronic, BCR-ABL Positive|Medication Adherence
Interventions: BEHAVIORAL: Pharmaceutical care and adherence aids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pancreatico Enteric Anastomosis Post Pancreaticoduodenectomy
Status: UNKNOWN
Conditions: Cancer of Pancreas
Interventions: PROCEDURE: Blumgart Anastomosis|PROCEDURE: Cattell Warren Anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SMOFlipid to Lessen the Severity of Neonatal Cholestasis
Status: TERMINATED
Conditions: Cholestasis|Jaundice, Obstructive
Interventions: DRUG: SMOFlipid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phenotyping Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) by Intravesical Contrast Enhanced - Magnetic Resonance Imaging (ICE-MRI) Bladder Permeability Assay
Status: RECRUITING
Conditions: IC - Interstitial Cystitis
Interventions: DRUG: Ferumoxytol|DRUG: Gadobutrol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Exercise Effect on Chemotherapy-Induced Neuropathic Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer, Breast|Cancer, Colorectal|Cancer, Lung|Cancer, Ovarian
Interventions: BEHAVIORAL: aerobic exercise intervention|OTHER: control group|BEHAVIORAL: resistive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Growth Hormone to Improve the Clinical Outcome of Assisted Fertility in Young Patients With Decreased Ovarian Reserve
Status: RECRUITING
Conditions: Infertility
Interventions: DRUG: Growth hormone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of TQB3473 Tablets in Subjects With Relapsed or Refractory Hematological Malignancies
Status: UNKNOWN
Conditions: Relapsed/Refractory Hematological Malignancies
Interventions: DRUG: TQB3473
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sedentary Screen Time Activities on Food Intake
Status: COMPLETED
Conditions: Exogenous Obesity
Interventions: BEHAVIORAL: Television Viewing before mealtime|BEHAVIORAL: Video Game Playing|BEHAVIORAL: Computer Use|BEHAVIORAL: Sitting quietly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Long-term Study of STAR-0215 in Participants With Hereditary Angioedema
Status: ENROLLING_BY_INVITATION
Conditions: Hereditary Angioedema
Interventions: DRUG: STAR-0215
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Marathon of Hope Cancer Centres Network Study for Ontario (MOHCCN-O)
Status: RECRUITING
Conditions: Breast Cancer|Colorectal Cancer|Pancreas Cancer|Kidney Cancer|Prostate Cancer|Ovary Cancer|Head and Neck Cancer|Leukemia|Lymphoma|Lung Cancer|Melanoma|Solid Tumor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Long-Chain Polyunsaturated Fatty Acids on Cognitive Performance and Mood
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Omega-3 fatty acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Empowering Girls: Health-seeking Behavior, Staying in School, and Preventing Risky Sex
Status: UNKNOWN
Conditions: Pregnancy Related|Behavior, Health
Interventions: BEHAVIORAL: Low tech health SMS messages|BEHAVIORAL: Low tech health Phone + SMS messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intravenous Fat Emulsion Comprised of Fish Oil in the Treatment of Parenteral Nutrition Induced Liver Injury in Infants
Status: APPROVED_FOR_MARKETING
Conditions: Total Parenteral Nutrition-induced Cholestasis
Interventions: DIETARY_SUPPLEMENT: Omegaven|DRUG: Omegaven|DRUG: Omegaven
Study Type: EXPANDED_ACCESS
Clinical trial: Role of Bumetanide in Treatment of Autism
Status: RECRUITING
Conditions: Autism
Interventions: DRUG: Bumetanide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MOTIV Study- Effect of Antidepressive Treatment by Escitalopram in Patients Undergoing Coronary Artery Bypass Grafting
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Itopride, on Symptoms of Functional Dyspepsia, Such as Indigestion, Bloating, Inability to Finish a Meal
Status: COMPLETED
Conditions: Dyspepsia
Interventions: DRUG: Itopride Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Cross Iron (Comparative Randomized Oral Versus Systemic IRON)
Status: COMPLETED
Conditions: Allogenic Transfusion|Perioperative Anaemia|Knee Arthroplasty|Hip Arthroplasty
Interventions: DRUG: ferrous glycine sulfate Tardyferon|DRUG: Epoetin Alfa|DRUG: ferric carboxymaltose Ferinject
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Adapted Cognitive/Affective Remediation for Cannabis Misuse in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: BEHAVIORAL: CET/PT|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Buccal Pad of Fat, Advanced Platelet Rich Fibrin, Fibrin Glue and Oxidized Cellulose Plug in Management of Oro-Antral Communication, Comparative Clinical Study
Status: COMPLETED
Conditions: Healthy Volunteers Only
Interventions: PROCEDURE: Buccal Pad of Fat|PROCEDURE: A-PRF|PROCEDURE: fibrin glue|PROCEDURE: oxidized cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Activity of AZD5122 When Given as a Single Dose to Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD5122|DRUG: Placebo|DRUG: AZD5122
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluating the Safety and Immune Response to Three HIV Vaccine Schedules in Healthy, HIV-Uninfected Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: DNA-HIV-PT123 vaccine|BIOLOGICAL: NYVAC-HIV-PT1 vaccine|BIOLOGICAL: NYVAC-HIV-PT4 vaccine|BIOLOGICAL: Placebo for DNA-HIV-PT123 vaccine|BIOLOGICAL: Placebo for NYVAC-HIV-PT1 vaccine|BIOLOGICAL: Placebo for NYVAC-HIV-PT4 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optimised Procedure in Patients With NSTEMI and CKD
Status: TERMINATED
Conditions: Non-ST-segment Elevation Myocardial Infarction|Chronic Kidney Disease
Interventions: PROCEDURE: coronary angiography|PROCEDURE: ischemic precondition|PROCEDURE: prior kidney irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of CMV Specific DLIs From 3-6/6 HLA Matched Family Member Following Nonmyeloablative Allo SCT
Status: TERMINATED
Conditions: Cytomegalovirus Infections
Interventions: BIOLOGICAL: CMV Specific T Cell donor lymphocyte infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of LY3435151 in Participants With Solid Tumors
Status: TERMINATED
Conditions: Solid Tumor|Triple-negative Breast Cancer|Gastric Adenocarcinoma|Head and Neck Squamous Cell Carcinoma|Cervical Carcinoma|High Grade Serous Ovarian Carcinoma|Hepatocellular Carcinoma|Undifferentiated Pleomorphic Sarcoma|Leiomyosarcoma
Interventions: DRUG: LY3435151|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccination With GSK 1024850A in Children Primed With GSK 1024850A & Boosted With Pneumovax 23™
Status: COMPLETED
Conditions: Infections, Streptococcal|Streptococcus Pneumoniae
Interventions: BIOLOGICAL: Pneumococcal conjugate vaccine GSK 1024850A|BIOLOGICAL: Pneumococcal conjugate vaccine Prevenar™ (Wyeth Lederle's)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Immune Response of United Kingdom (UK) Infants Receiving DTaP/Hib/IPV, Meningococcal C Conjugate and Pneumococcal Conjugate Vaccines, Antibody Persistence and Responses to Booster Doses in the Second Year of Life
Status: COMPLETED
Conditions: Meningococcal Infections|Pneumococcal Infections
Interventions: BIOLOGICAL: NeisVacC (Meningococcal C conjugate vaccine)|BIOLOGICAL: Menjugate (Meningococcal C conjugate vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Recurrent GBM Treated With Neurosurgical Resection and IORT Using the Xoft Axxent eBx System and Bevacizumab
Status: TERMINATED
Conditions: Glioblastoma|Recurrent Glioblastoma|GBM|Recurrent GBM
Interventions: RADIATION: Radiation: Intra-operative Radiation Therapy - IORT|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK/PD Clinical Trial of YYD601 in Healthy Adult Male
Status: COMPLETED
Conditions: GERD
Interventions: DRUG: YYD601 1|DRUG: YYD601 2|DRUG: YYD601 3|DRUG: Nexium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study to Explore the Safety and Activity of Dersalazine in Patients With Mild to Moderate Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Dersalazine sodium|DRUG: Mesalazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ifenprodil as a ReMyelinating repurpOsed Drug in Multiple Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis|Remitting Relapsing Multiple Sclerosis
Interventions: DRUG: Ifenprodil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: ZGN-440 (Beloranib for Subcutaneous Injection) for Treatment of Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: ZGN-440|DRUG: ZGN-440 sterile diluent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Benralizumab for Eosinophilic Gastritis (BEGS)
Status: COMPLETED
Conditions: Eosinophilic Gastritis or Gastroenteritis
Interventions: BIOLOGICAL: Benralizumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Dose Escalated BGB324 in Previously Treated Non-small Cell Lung Cancer.
Status: COMPLETED
Conditions: Non-Small Cell Lung Carcinoma
Interventions: DRUG: BGB324|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Preurodynamic With Posturodynamic Levofloxacin on the Incidence of UTI
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: DRUG: Pre-urodynamic Levofloxacin|DRUG: Post-urodynamic Levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of FT218 in Idiopathic Hypersomnia (REVITALYZ)
Status: RECRUITING
Conditions: Idiopathic Hypersomnia
Interventions: DRUG: FT218|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PEEP Levels Selected by PEEP Titration and PEEP Levels Routinely Used in Post-operative Cardiac Patients With Hypoxemic Respiratory Failure
Status: UNKNOWN
Conditions: Post Operative Cardiac Surgery|ARDS|Hypoxemic Respiratory Failure
Interventions: OTHER: Titration|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Telmisartan/Amlodipine Fixed Dose Combination in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Telmisartan/Amlodipine|OTHER: high fat, high caloric meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate.
Status: UNKNOWN
Conditions: Colorectal Neoplasm|Iron Deficiency Anemia
Interventions: DRUG: i.v. iron sucrose|DRUG: Oral iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clipping Versus No Hair Removal and the Risk of Surgical Site Infections
Status: COMPLETED
Conditions: Surgical Site Infection|Superficial Surgical Site Infection|Deep Surgical Site Infection|Organ/Space Surgical Site Infection
Interventions: PROCEDURE: Hair clipping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Safety and Efficacy of Thermal Ablation Combined With Apatinib and Carilimub for Advanced Liver Cancer
Status: UNKNOWN
Conditions: BCLC Stage B Hepatocellular Carcinoma|BCLC Stage C Hepatocellular Carcinoma
Interventions: DRUG: Apatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimisation of Follicular Recruitment in IVM Cycles
Status: COMPLETED
Conditions: Infertility, Female|Polycystic Ovary Syndrome
Interventions: PROCEDURE: blood sampling|PROCEDURE: transvaginal ultrasound scanning|PROCEDURE: oocyte retrieval for IVM|DRUG: Corifollitropin Alfa|DRUG: Follitropin beta|DRUG: oral contraceptive pill pretreatment (Marvelon)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Simvastatin in Alcoholic Liver Fibrosis
Status: RECRUITING
Conditions: Liver Fibrosis|Alcohol Abuse
Interventions: DRUG: Simvastatin 40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Pregabalin and Ketamine to Prevent Phantom Pain
Status: WITHDRAWN
Conditions: Phantom Pain
Interventions: DRUG: Pregabalin|DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Systemic Adverse Effects After Osteopathic Treatment and Vitamin C
Status: COMPLETED
Conditions: Adverse Effects|Ascorbic Acid|Oxidative Stress
Interventions: DIETARY_SUPPLEMENT: 1gr. Vitamine C|OTHER: 1gr Placebo|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Botulinum Toxin Type A for Treating Allodynic Pain in SCI and MS
Status: TERMINATED
Conditions: Neuropathic Pain|Allodynia
Interventions: DRUG: Botulinum Toxin Type A|DRUG: Normal Saline for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blood Flow Restriction Therapy in Lower Limb Extensor Injuries
Status: RECRUITING
Conditions: Lower Limb Injury
Interventions: BEHAVIORAL: Physical Therapy with pressure cuff|BEHAVIORAL: Physical Therapy with placebo pressure cuff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Accordance Between Event Detection of prismaLINE Devices and Polysomnography Using Full Face Masks
Status: NOT_YET_RECRUITING
Conditions: Sleep Apnea Syndromes
Interventions: OTHER: PAP therapy setting|OTHER: exclusive use of Löwenstein Medical full face masks
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Omega 3 on Pregnancy Complicated by Asymmetrical Intrauterine Growth Restriction
Status: COMPLETED
Conditions: Intrauterine Growth Restriction
Interventions: DRUG: Low dose aspirin|DRUG: Omega 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gabapral in Pediatric IBS
Status: NOT_YET_RECRUITING
Conditions: Bifidobacterium Adolescentis PRL2019|IBS|Pediatric
Interventions: DRUG: Gabapral|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Early Phase I Study of IPdR Absorption, Metabolism, and Safety in Patients With Advanced Solid Tumors and Lymphomas
Status: COMPLETED
Conditions: Neoplasms|Lymphoma
Interventions: DRUG: IPdR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of PP-007 in Subjects With Acute Ischemic Stroke
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: BIOLOGICAL: PP-007 (Two doses administered 24±6 hours apart) + SOC (IVT or MT or IVT+MT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of PCSK9 Inhibition by Evolocumab on Postprandial Lipid Metabolism in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Evolocumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hospital Discharge Oral Nutrition Support Trial
Status: COMPLETED
Conditions: Malnutrition
Interventions: DIETARY_SUPPLEMENT: Oral Nutritional Supplement 1|DIETARY_SUPPLEMENT: Oral Nutritional Supplement 2|DIETARY_SUPPLEMENT: Dietary Advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Metformin for Treatment Antipsychotic-induced Metabolic Syndrome in Bipolar Disorder Patients
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Metformin|OTHER: Starch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Response Relationships for Hemidiaphragmatic Paresis Following Ultrasound-Guided Supraclavicular Block
Status: COMPLETED
Conditions: Surgery of Right Upper Extremity
Interventions: DIAGNOSTIC_TEST: Ultrasound Imaging|DRUG: Supraclavicular Block|OTHER: Bedside Negative Inspiratory Force Meter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alcohol Research Consortium in HIV-Intervention Research Arm
Status: COMPLETED
Conditions: HIV Positive|Alcohol Use
Interventions: BEHAVIORAL: Computerized Brief Intervention (CBI)|BEHAVIORAL: CBT4CBT|DRUG: Recommendation and Counseling for Alcohol Pharmacotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Ablation With Medical Therapy in Patients With Ventricular Tachycardia
Status: WITHDRAWN
Conditions: Ventricular Tachycardia|Coronary Artery Disease
Interventions: PROCEDURE: Catheter Ablation|DRUG: Medical therapy (sotalol or amiodarone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does a Different Local Anesthetic Improve Pain After Carpal Tunnel Release?
Status: UNKNOWN
Conditions: Carpal Tunnel Syndrome
Interventions: DRUG: Local Anesthetics Lidocaine|DRUG: Local Anesthetics Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zimberelimab (AB122) With TIGIT Inhibitor Domvanalimab (AB154) in PD-1 Relapsed/Refractory Melanoma
Status: RECRUITING
Conditions: Melanoma
Interventions: DRUG: Zimberelimab|DRUG: Domvanalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Trial Using EaseVRx For Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Lower Back Pain
Interventions: DEVICE: EaseVRx headset with active intervention|DEVICE: EaseVRx headset without active intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Application of High Flow Nasal Cannula for Prevention of Post-extubation Atelectasis in Children Undergoing Surgery
Status: UNKNOWN
Conditions: Atelectasis
Interventions: PROCEDURE: high flow nasal cannula oxygenation|PROCEDURE: nasal prong
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
Status: RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Locally Advanced Malignant Solid Neoplasm|Malignant Female Reproductive System Neoplasm|Metastatic HER2-Negative Breast Carcinoma|Metastatic Malignant Solid Neoplasm|Recurrent Endometrial Carcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Malignant Female Reproductive System Neoplasm|Recurrent Malignant Solid Neoplasm|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Unresectable HER2-Negative Breast Carcinoma|Unresectable Malignant Solid Neoplasm
Interventions: DRUG: Alpelisib|DRUG: Binimetinib|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|PROCEDURE: Echocardiography|DRUG: Fluorouracil|DRUG: Fulvestrant|DRUG: Ipatasertib|DRUG: Leucovorin|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Multigated Acquisition Scan|PROCEDURE: Mutation Carrier Screening|DRUG: Neratinib Maleate|DRUG: Nilotinib Hydrochloride Monohydrate|DRUG: Olaparib|DRUG: Oxaliplatin|DRUG: Paclitaxel|DRUG: Palbociclib|BIOLOGICAL: Panitumumab|PROCEDURE: Positron Emission Tomography|DRUG: Selumetinib Sulfate|DRUG: Sotorasib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Active Immunization of HIV-1 Infected, Pregnant Women With CD4 Lymphocyte Counts >= 400/mm3: A Phase I Study of Safety and Immunogenicity of VaxSyn Recombinant gp160 (NOTE: Some Patients Receive Placebo)
Status: COMPLETED
Conditions: HIV Infections|Pregnancy|HIV Seronegativity
Interventions: BIOLOGICAL: gp160 Vaccine (MicroGeneSys)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Open Label Study Comparing Efficacy and Safety of Dabigatran Etexilate to Standard of Care in Paediatric Patients With Venous Thromboembolism (VTE)
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: dabigatran etexilate|DRUG: standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modified Dantien Salee Yoga Training Program in Chronic Obstructive Pulmonary Disease Rehabilitation
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: Modified Dantien Salee Yoga Training Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of an Investigational Multi-Purpose Disinfecting Solution
Status: COMPLETED
Conditions: Healthy Contact Lens Wearers
Interventions: DEVICE: Alcon MPDS|DEVICE: ReNu Fresh MPS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Evaluating the Safety, Tolerability and Pharmacokinetics of GDC-0917 Administered to Patients With Refractory Solid Tumors or Lymphoma
Status: COMPLETED
Conditions: Solid Cancers
Interventions: DRUG: GDC-0917
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noradrenergic and Stress-Related Etiologies of Chronic Fatigue Syndrome
Status: COMPLETED
Conditions: Chronic Fatigue Syndrome
Interventions: OTHER: Posture Study, Autonomic Function Tests, and a Stress Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Autologous Dendritic Cells in Treating Patients With Metastatic Kidney Cancer
Status: COMPLETED
Conditions: Clear Cell Renal Cell Carcinoma|Recurrent Renal Cell Cancer|Stage IV Renal Cell Cancer
Interventions: BIOLOGICAL: AdGMCAIX-transduced autologous dendritic cells|BIOLOGICAL: therapeutic autologous dendritic cells|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Mechanism of ZhenQiFuZheng in the Treatment of Allergic Rhinitis Based on Intestinal Flora and Metabolites
Status: NOT_YET_RECRUITING
Conditions: Rhinitis, Allergic
Interventions: DRUG: ZhenQi FuZheng granules (ShiDaiYangGuang)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of RVM-V001 in Healthy Individuals Previously Vaccinated With BNT162b2 and mRNA-1273
Status: TERMINATED
Conditions: Infectious Disease|COVID-19
Interventions: BIOLOGICAL: RVM-V001 10 µg|BIOLOGICAL: RVM-V001 30 µg|BIOLOGICAL: RVM-V001 60 µg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment of the Prevalence of TTR Amyloid Neuropathy in a Population of Patients With Neuropathy of Unknown Aetiology
Status: COMPLETED
Conditions: Familial Amyloid Neuropathy|Transthyretin Amyloidosis
Interventions: GENETIC: blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessing BAY86-9766 Plus Sorafenib for the Treatment of Liver Cancer.
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: BAY86-9766 MEK Inhibitor + Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study on Incidence and Prevention of Contrast-induced Nephropathy in Croatia
Status: COMPLETED
Conditions: Kidney Diseases|Contrast Media Reaction
Interventions: DRUG: Sodium bicarbonate|DRUG: N-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Preoperative Warming, Hypothermia and Functional Recovery in Total Hip Arthroplasty
Status: COMPLETED
Conditions: Hypothermia Following Anesthesia|Hypothermia; Anesthesia
Interventions: PROCEDURE: Preoperative warming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Arm-hand Boost Program During Inpatient Rehabilitation After Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: BEHAVIORAL: Arm-hand BOOST program|BEHAVIORAL: Control program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin C & Thiamine to Treat Sepsis and Septic Shock
Status: COMPLETED
Conditions: Sepsis|Septic Shock
Interventions: DRUG: Vitamin C|DRUG: Vitamin B1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study for 601 Versus Ranibizumab in Patients With Vision Loss
Status: RECRUITING
Conditions: Branch Retinal Vein Occlusion
Interventions: DRUG: 601 1.25mg|DRUG: ranibizumab 0.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Advanced Care at Home vs. Traditional Brick-and-Mortar Hospital Care in Acutely Ill Adults: A Randomized Clinical Trial
Status: TERMINATED
Conditions: The Trial Will Compare Two Care Delivery Models That Are Currently Being Used in Routine Practice Settings for Acute Hospitalization
Interventions: OTHER: Advanced Care at Home (ACH)|OTHER: Traditional Brick-and-Mortar Hospitalization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase 1 Study of Terameprocol (EM-1421) in Patients With Leukemia
Status: TERMINATED
Conditions: Leukemias|Acute Myeloid Leukemia (AML)|Acute Lymphocytic Leukemia (ALL)|Adult T Cell Leukemia (ATL)|Chronic Myeloid Leukemia (CML-BP)|Chronic Lymphocytic Leukemia (CLL)|Myelodysplastic Syndrome (MDS)|Chronic Myelomonocytic Leukemia (CMML)
Interventions: DRUG: Terameprocol (EM-1421)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laryngeal Adaptation for Speech and Swallowing
Status: WITHDRAWN
Conditions: Stroke|Spinocerebellar Ataxia|Cerebral Stroke|Dysphagia|Dysarthria
Interventions: DEVICE: Intermittent Perturbation to Continuous Perturbation|DEVICE: Continuous Perturbation to Intermittent Perturbation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Function and QOL Undergoing Whole-Body Vibration and Exercise in End-Stage Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis|Pain, Joint
Interventions: OTHER: Whole-Body Vibration|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ruxolitinib Phosphate, Tacrolimus and Sirolimus in Preventing Acute Graft-versus-Host Disease During Reduced Intensity Donor Hematopoietic Cell Transplant in Patients With Myelofibrosis
Status: WITHDRAWN
Conditions: Acute Myeloid Leukemia in Remission|Primary Myelofibrosis|Primary Myelofibrosis, Prefibrotic Stage|Secondary Acute Myeloid Leukemia|Secondary Myelofibrosis
Interventions: PROCEDURE: Allogeneic Bone Marrow Transplantation|PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|DRUG: Melphalan|PROCEDURE: Peripheral Blood Stem Cell Transplantation|OTHER: Pharmacological Study|DRUG: Ruxolitinib Phosphate|DRUG: Sirolimus|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of the Safety and Efficacy of the Dermal Filler "mARG-01-17" in Facial Rejuvenation Therapy
Status: COMPLETED
Conditions: Facial Rejuvenation
Interventions: DEVICE: mARG-01-17 (mesohyal AGRIBENONE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Tolerability, and Optimal Dose of Candidate GBM Vaccine VBI-1901 in Recurrent GBM Subjects
Status: RECRUITING
Conditions: Glioblastoma Multiforme
Interventions: BIOLOGICAL: VBI-1901|DRUG: Carmustine|DRUG: Lomustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Advance Care Planning: Promoting Effective and Aligned Communication in the Elderly
Status: ACTIVE_NOT_RECRUITING
Conditions: Other Cancer
Interventions: OTHER: Clinician Communication Skills Training|OTHER: Advance Care Planning (ACP) Decisions Videos Decisions Aids|OTHER: Video Declarations (ViDec)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effectiveness of Two Maxillary Expanders in Improving the Transverse Skeletal and Dental Dimensions in Patients With Cleft Lip and Palate
Status: COMPLETED
Conditions: Cleft Lip and Palate|Maxillary Expansion
Interventions: DEVICE: Maxillary Expansion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficiency of a Whole Body Vibration Training Program in Adult Renal Transplanted Patients
Status: UNKNOWN
Conditions: Kidney Transplantation|Exercise
Interventions: OTHER: Platform|OTHER: Platform sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of HH-120 Nasal Spray in Close Contacts of Those Diagnosed With COVID-19
Status: COMPLETED
Conditions: COVID-19|SARS-CoV-2 Infection
Interventions: DRUG: HH-120 Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CD19-targeted CAR-T Cell Therapy for MRD+ B-cell Malignancies After Autologous Stem Cell Transplantation
Status: UNKNOWN
Conditions: Lymphoma, B-Cell|Leukemia, B-Cell|Minimal Disease, Residual
Interventions: BIOLOGICAL: CD19-targeted CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-stage Surgery With Antibiotic-loaded Hydrogel Coated Implants Versus Two Stage Surgery for Secondary Prevention of Complex Chronic Periprosthetic Hip Joint Infection
Status: RECRUITING
Conditions: Hip Prosthesis Infection
Interventions: DEVICE: Defensive Antiadhesive Coating DAC®, Novagenit SRL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modified Enhanced Recovery Program in Emergency Surgery (MERES)
Status: COMPLETED
Conditions: Acute Appendicitis|Acute Appendicitis With Rupture|Acute Appendicitis With Peritonitis|Acute Appendicitis Without Peritonitis
Interventions: PROCEDURE: Laparoscopic appendectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple CAR-T Cell Therapy Targeting AML
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: CLL-1, CD33 and/or CD123-specific CAR gene-engineered T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects and Safety of OPK-88003 Dose Escalation in Type 2 Diabetes Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: OPK-88003|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Studies of Elevated Parathyroid Activity
Status: COMPLETED
Conditions: Hyperparathyroidism|Hypercalcemia|Parathyroid Neoplasm|Multiple Endocrine Neoplasia|MEN1
Interventions: DRUG: 68Ga-Dotatate|DRUG: 18F-DOPA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Filgrastim in Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: G-CSF; filgrastim|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Regorafenib Following Completion of Standard Chemotherapy for Patients With Colon Cancer
Status: TERMINATED
Conditions: Stage III (IIIB or IIIC) Colon Cancer
Interventions: DRUG: Regorafenib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Can Targeted Exercise Improve Knee Strength Following ACLR (RATE)
Status: COMPLETED
Conditions: Rupture of Anterior Cruciate Ligament|Muscle Degeneration|Gait, Unsteady
Interventions: OTHER: Targeted exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Outcomes Between Anticoagulation and DAPT Therapy in AF Patients Successfully Undergoing LAAO
Status: RECRUITING
Conditions: Left Atrial Appendage Thrombosis|Thrombi|Stroke
Interventions: DRUG: Rivaroxaban|DRUG: DAPT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Prevention of Akute Kidney Injury, Hearttransplant, ANP
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: DRUG: ANP|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective Study to Evaluate the Raindrop Near Vision Inlay in Presbyopic Patients With Treatments to Optimize the Ocular Surface Before Implantation
Status: UNKNOWN
Conditions: Presbyopia
Interventions: DRUG: Mitomycin C|DEVICE: Raindrop Near Vision Inlay
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: EP1300 Polyepitope DNA Vaccine Against Plasmodium Falciparum Malaria
Status: COMPLETED
Conditions: Plasmodium Falciparum Malaria
Interventions: DRUG: Placebo|BIOLOGICAL: EP-1300
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION