pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Long-Acting HIV Pre-Exposure Prophylaxis Integrated With Sexual and Reproductive Health - cRCT
Status: RECRUITING
Conditions: HIV Infections
Interventions: DRUG: APRETUDE (cabotegravir) 600 mg\3 mL|DRUG: DAPIRING (Dapivirine) 25mg Vaginal Ring|DRUG: tenofovir disoproxil and emtricitabine|DRUG: Tenofovir Disoproxil, Lamuvidine and Dolutegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Brentuximab Vedotin and Lenalidomide for Relapsed or Refractory Diffuse Large B-cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Large B-Cell, Diffuse
Interventions: DRUG: Brentuximab vedotin|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Application of Mepitel Film During Radiation Therapy to Reduce Radiation Related Redness and Peeling in Breast Cancer Patients Following Mastectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Carcinoma|Mastectomy Patient
Interventions: OTHER: Best Practice|DEVICE: Wound Dressing Material|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Neuroprotective Effect of Vitamin B6 and Vitamin B12 Against Vincristine Induced Neurotoxicity in Acute Lymphoblastic Leukaemia Patients
Status: COMPLETED
Conditions: Vincristine Induced Neurotoxicity|Acute Lymphoblastic Leukaemia
Interventions: DRUG: Injection Mecobalamin|DRUG: Tablet Pyridoxine hydrochlorid|DRUG: Normal saline|DRUG: Oral Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Dietary Assessment Study Via Digital Images
Status: COMPLETED
Conditions: Diet Habit
Interventions: DEVICE: Dietary Assessment of Meal A using images taken by Sony Smarteyeglass|DEVICE: Dietary Assessment of Meal B using Images taken by Sony Smarteyeglass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Ureteral Stenting After Retrograde Intrarenal Surgery for Renal Stones
Status: RECRUITING
Conditions: Kidney Stone|Retrograde Intrarenal Surgery|Ureteral Stent
Interventions: PROCEDURE: Retrograde intrarenal surgery with external ureteral catheter|PROCEDURE: Retrograde intrarenal surgery with double J internal ureteral stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety in Hemolytic Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients Treated With Eculizumab
Status: COMPLETED
Conditions: Hemoglobinuria, Paroxysmal
Interventions: DRUG: eculizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mycoplasma Infection Rate and Macrolides Resistance in Children With Acute Respiratory Tract Infection
Status: UNKNOWN
Conditions: Respiratory Tract Infections
Interventions: DRUG: Azithromycin|DRUG: non-macrolides antibiotics|DIAGNOSTIC_TEST: Mycoplasma detection|OTHER: Data collection|OTHER: Data collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Aerobic EXercise on MiCroVAscular RarefacTION in Chinese Mild HyperteNsive Patients（EXCAVATION-CHN1）
Status: UNKNOWN
Conditions: Primary Hypertension
Interventions: BEHAVIORAL: Aerobic Exercise|BEHAVIORAL: Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of California Tri-pull Taping Method on Shoulder Subluxation, Pain, Active Range of Motion and Upper Limb Functional Recovery After Stroke - A Pre Test Post Test Design
Status: COMPLETED
Conditions: Post Stroke Shoulder Subluxation
Interventions: OTHER: california tri-pull taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of AK101 in Subjects With Moderately to Severely Active Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: BIOLOGICAL: AK101 IV|BIOLOGICAL: AK101 SC|BIOLOGICAL: Placebo|BIOLOGICAL: AK101 IV/AK101 SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of 2-hydroxyflutamide (Liproca Depot), Injected Into the Prostate in Patients With Localized Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: 2-hydroxyflutamide (2-HOF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Intravascular Ultrasound-Guided vs. Angiography-guided Angioplasty and Dual-antiplatelet v. Triple-antiplatelet Therapy for Outcomes of Drug-coated Balloon in the Treatment of Femoropopliteal Artery Disease (IVUS-DCB)
Status: COMPLETED
Conditions: Femoropopliteal Artery Disease
Interventions: PROCEDURE: IVUS-guided angioplasty|PROCEDURE: Angiography-guided angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sitravatinib in Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer Stage IV|Triple Negative Breast Cancer|Breast Neoplasms|Breast Cancer Metastatic
Interventions: DRUG: Sitravatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Cardiac Function in COPD Patients After Administration of Budesonide/Formoterol (Symbicort®) Versus Placebo
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Budesonide / Formoterol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation on the Efficacy of Bronchodilator Nebulization Via High Flow Nasal Cannula
Status: COMPLETED
Conditions: High Flow Nasal Cannula
Interventions: DEVICE: High flow nasal cannula|DRUG: Albuterol Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project WHADE: A Partner-Based Physical Activity Program for Women
Status: RECRUITING
Conditions: Hypertension|Type 2 Diabetes|Metabolic Syndrome|Smoking|High Cholesterol|PreDiabetes|Prehypertension
Interventions: BEHAVIORAL: Project WHADE: A Partner-Based Physical Activity Program for Women
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prospective Observational Study Comparing Calcium and Sodium Levofolinate in Combination With 5-Fluorouracil (5FU) /or in FOLFIRI Regimen
Status: COMPLETED
Conditions: Gastrointestinal Cancer|CALCIUM LEVOFOLINATO (Ca-lev)|SODIUM LEVOFOLINATO (Na-lev)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multi-Target Pallidal and Thalamic Deep Brain Stimulation for Hemi-Dystonia
Status: UNKNOWN
Conditions: Dystonia|Dystonia, Secondary
Interventions: DEVICE: Deep Brain Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Placebo Controlled Study of ONO2506PO in the Presence of Riluzole in Patients With Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis (ALS)
Interventions: DRUG: ONO-2506PO|DRUG: ONO-2506PO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Swedish Multicenter Trial of Outpatient Prevention of Leg Clots
Status: RECRUITING
Conditions: Achilles Tendon Rupture|Ankle Fractures|Venous Thromboembolism
Interventions: DEVICE: Adjuvant IPC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Randomized Controlled Trial to Assess the Impact of Live and Recorded Music-Based Interventions on Pre-operative Stress, Mood, Pain and Biomarkers, in Neurosurgical Patients (Music-STAR Trial)
Status: NOT_YET_RECRUITING
Conditions: Stress|Pain
Interventions: OTHER: Steinway Spirio M recording/player piano
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Perianal Maceration in Pediatric Ostomy Closure Patients
Status: COMPLETED
Conditions: Perianal Dermatitis|Diaper Dermatitis|Postoperative Complications|Colostomy Site|Ileostomy - Stoma
Interventions: OTHER: Stool application|OTHER: Standard of care skincare
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of the Effect on Non-small Cell Lung Cancer of the Investigational Drug Motexafin Gadolinium When Used in Combination With Docetaxel (Taxotere)
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DRUG: Motexafin Gadolinium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Exercise and Phytoestrogen on Bone, Metabolic Syndrome Criteria and Complaints of the Early Menopause
Status: TERMINATED
Conditions: Bone Diseases|Metabolic Syndrome X|Coronary Disease
Interventions: BEHAVIORAL: exercise|BEHAVIORAL: exercise + cimicifuga racemosa|BEHAVIORAL: wellness control, placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Consumption of Beta-glucans on the Intestinal Microbiota and Glucose and Lipid Metabolism
Status: COMPLETED
Conditions: Metabolic Syndrome|Dyslipidemia|Obesity, Abdominal|Hyperglycemia|Hypertension
Interventions: DIETARY_SUPPLEMENT: Bread with added beta-glucans|DIETARY_SUPPLEMENT: Placebo Comparator: Bread without added beta-glucans
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of Artificial Intelligence as Decision Support System in VIA (PRESCRIP-TEC)
Status: ACTIVE_NOT_RECRUITING
Conditions: HPV Infection|Cervix Cancer|Cervical Dysplasia
Interventions: DIAGNOSTIC_TEST: Validation of AI-DSS in Bangladesh|DIAGNOSTIC_TEST: Validation of AI-DSS in Uganda|DIAGNOSTIC_TEST: Validation of AI-DSS in India
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study of Brimonidine and Timolol Ophthalmic Solution With Latanoprost Compared With Latanoprost in Glaucoma Patients
Status: TERMINATED
Conditions: Glaucoma, Angle-Closure
Interventions: DRUG: brimonidine 0.2%/timolol 0.5% fixed combination ophthalmic solution|DRUG: latanoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate Tolerability and Security of TQB2858 Injection in Subjects With Advanced Pancreatic Carcinoma
Status: TERMINATED
Conditions: Pancreatic Carcinoma
Interventions: DRUG: TQB2858 injection|DRUG: Anlotinib Hydrochloride Capsule|DRUG: Gemcitabine hydrochloride for injection|DRUG: Paclitaxel for injection (albumin bound)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BCMA and CD19 Targeted Fast Dual CART for Chromosomal Abnomalities High-risk BCMA+ Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: GC012F injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Motor Cortex Versus Insula Stimulation Using Transcranial Current Stimulation on Chronic Post-mastectomy Pain
Status: COMPLETED
Conditions: Post-Mastectomy Chronic Pain Syndrome
Interventions: DEVICE: Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Determinants of Alpha-aminoadipic Acid (2-AAA) and Relationship to Diabetes: Study 3
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: L-Lysine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Muscle Energy Technique Versus Myofascial Release on Cervical and Lumbar Pain
Status: COMPLETED
Conditions: Lumbar Pain Syndrome|Cervical Pain
Interventions: OTHER: Myofascial release|OTHER: Muscle energy technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Opioid Free vs. Standard Perioperative Pain Regimen for Anterior Cervical Discectomy and Fusion (ACDF) Surgery
Status: TERMINATED
Conditions: Opioid Use|Spinal Diseases|Surgery--Complications|Surgery|Postoperative Pain
Interventions: DRUG: Opioid Analgesic|DRUG: Opioid-Free Postoperative Pain Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interpretation of Health News Items Reporting Results of Phase I/II (Non-randomized) Trials With or Without Spin by English-speaking Population
Status: UNKNOWN
Conditions: The Study Focus on no Specific Condition
Interventions: OTHER: News items with spin|OTHER: News items without spin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Randomized Controlled Trial of Health Care to Elderly Patients.
Status: COMPLETED
Conditions: Congestive Heart Failure|Angina Pectoris|Asthma|Pneumonia|Fractures
Interventions: OTHER: Multicomponent treatment|OTHER: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Goal Directed Fluid Therapy
Status: COMPLETED
Conditions: Goal Directed Fluid Therapy
Interventions: DRUG: fluidotherapy with ringer-lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Personalized Allocation of Defibrillators in Non-ischemic Heart Failure (SPANISH-1)
Status: RECRUITING
Conditions: Non-ischemic Dilated Cardiomyopathy
Interventions: OTHER: Control Strategy|OTHER: Personalized precision ICD implantation Strategy based in genetic findings and CMR results
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pharmacodynamic Effects of Lixisenatide Compared to Liraglutide in Patients With Type 2 Diabetes Not Adequately Controlled With Insulin Glargine With or Without Metformin
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Lixisenatide (AVE0010)|DRUG: Liraglutide|DRUG: Insulin Glargine|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DDP ip Combined With AG in PDAC With Peritoneal Metastasis
Status: UNKNOWN
Conditions: Pancreatic Neoplasm
Interventions: DRUG: intraperitoneal (IP) Cisplatin combined with intravenous gemcitabine + nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Transcendental Meditation on Physician Burnout and Depression
Status: COMPLETED
Conditions: Burnout, Professional|Depression|Insomnia|Perceived Stress|Resilience
Interventions: BEHAVIORAL: Transcendental Meditation technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Influence of Ritonavir, Alone and in Combination With Lopinavir, on Fenofibric Acid Pharmacokinetics in Healthy Volunteers
Status: COMPLETED
Conditions: HIV|Fenofibrate|Protease Inhibitors|Hypertriglyceridemia|Glucuronosyltransferase
Interventions: DRUG: Fenofibrate|DRUG: Ritonavir|DRUG: Lopinavir/Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Brachyspira and Intestinal Allergy-like Immune Reactions in Patients With Irritable Bowel Syndrome (IBS)
Status: RECRUITING
Conditions: Irritable Bowel Syndrome|Food Sensitivity
Interventions: OTHER: Elimination and re-introduction of CLE or COLAP positive food item(s)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Energy Instruments and Stapling Device to Dissect Intersegmental Plane in Segmentectomy
Status: TERMINATED
Conditions: Segmentectomy
Interventions: DEVICE: Energy Instruments|DEVICE: Stapling Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D and Omega-3 Adiposity Trial (VITAL Adiposity)
Status: UNKNOWN
Conditions: Adiposity
Interventions: DIETARY_SUPPLEMENT: Vitamin D3 (cholecalciferol), 2000 IU per day|DRUG: omega-3 fatty acids (fish oil)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of IL-6 in Synovial Fluid in Obese and Normal Weight Patients Suffering From Gonarthrosis During PTA
Status: COMPLETED
Conditions: IL-6 Concentration in the Synovial Fluid of Obese Patients is 100% Higher Than the IL-6 Concentration of the Synovial Fluid in Normal Weight Patients
Interventions: DIAGNOSTIC_TEST: Evaluation of IL-6 biomarkers in synovial fluid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Navigant Study- Treatment Patterns in mCRPC (Metastatic Castrate Resistant Prostate Cancer )
Status: COMPLETED
Conditions: Prostatic Neoplasms, Castration-Resistant
Interventions: DRUG: Xofigo (Radium-223 dichloride, BAY88-8223)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nimotuzumab Plus NALIRIFOX in Locally Advanced Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Pancreatic Cancer
Interventions: DRUG: Nimotuzumab+ NALIRIFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Compare Anti-VEGF Monotherapy With Anti-VEGF and EPM Grid Laser Combination Therapy for Diabetic Macular Edema
Status: UNKNOWN
Conditions: Diabetic Macula Edema
Interventions: PROCEDURE: End-Point-Management grid laser|DRUG: ranibizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myo-Electrical and Nerve Root Function Response to Focused Extracorpeal Shock Wave in Cervical Radiculopathy
Status: RECRUITING
Conditions: Cervical Radiculopathy
Interventions: DEVICE: Focused Extracorpeal Shock wave|DEVICE: Sham Extracorpeal shock wave
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A New Approach in Chronic Pain; Acceptance & Commitment Therapy-Exposure & Perspective Taking (ACT-EPT)
Status: COMPLETED
Conditions: Chronic Pain
Interventions: BEHAVIORAL: Acceptance & Commitment Therapy-Exposure and Perspective Taking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multidisciplinary Day-hospital Versus Waiting List Management of Post-COVID-19 Persistent Symptoms (ECHAP-COVID)
Status: RECRUITING
Conditions: Post COVID-19 Condition
Interventions: BEHAVIORAL: Personalized multidisciplinary day-hospital intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Salsalate to Target Adipocyte Macrophage Infiltration
Status: COMPLETED
Conditions: Diabetes Risk
Interventions: DRUG: Salsalate (4 g/day)|DRUG: Placebo (4 g/day)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Chinese Herbal Medicine Qing Re Huo Xue in Patients With Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Qing Re Huo Xue (QRHX)|DRUG: Methotrexate|DRUG: dummy Qing Re Huo Xue (QRHX)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Placebo Controlled Study to Show That Rasagiline May Slow Disease Progression for Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Rasagiline Mesylate|DRUG: Rasagiline Mesylate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dopamine and Insulin Resistance
Status: COMPLETED
Conditions: Obesity
Interventions: RADIATION: PET scan|PROCEDURE: Oral glucose tolerance test|PROCEDURE: MRI|BEHAVIORAL: Psychological scales to assess attitudes and behaviors related to eating and quality of life|OTHER: Caloric Restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pilot Trial of Targeted Immune-Depleting Chemotherapy and Reduced-Intensity Matched Unrelated Double Cord Blood Transplant for the Treatment of Leukemias, Lymphomas, and Pre-Malignant Blood Disorders
Status: TERMINATED
Conditions: Leukemia|Non-Hodgkins Lymphoma|Hodgkins Lymphoma|MDS|Multiple Myeloma
Interventions: DRUG: EPOCH-F/R|DRUG: FLAG|DRUG: Transplant Preparative Regimen (Flu/Cy/Mes)|DRUG: GVHD Prophylaxis (tacrolimus and sirolimus)|PROCEDURE: Double Cord Blood Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-Biopharmaceutical Immunization: Prediction and Analysis of Clinical Relevance to Minimize the Risk of Immunization in Rheumatoid Arthritis Patients or Juvenile Idiopathic Arthritis Patients
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Juvenile Idiopathic Arthritis
Interventions: PROCEDURE: Sampling of blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Noninvasive Continuous Blood Pressure Monitoring for Cesarean Delivery
Status: COMPLETED
Conditions: Cesarean Section Complications|Hypotension
Interventions: DEVICE: ClearSight System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: S1417CD Financial Impact Assessment Tool in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Stage IVA Colon Cancer|Stage IVA Rectal Cancer|Stage IVB Colon Cancer|Stage IVB Rectal Cancer
Interventions: OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparing Clinical Outcomes Between Ketamine-midazolam and Morphine-midazolam for Continous Sedation in ICU Patients.
Status: TERMINATED
Conditions: Critical Illness
Interventions: COMBINATION_PRODUCT: Ketamine-Midazolam|COMBINATION_PRODUCT: Morphine -Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral Adenosine-triphosphate (ATP) on Human Muscle Performance
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DIETARY_SUPPLEMENT: PeakATP 250|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: PeakATP 400|DIETARY_SUPPLEMENT: PeakATP 400 plus proprietary blend
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Complementary and Alternative Medicine for Urological Symptoms(CAMUS)
Status: COMPLETED
Conditions: Urological
Interventions: DRUG: Saw Palmetto - first 24 weeks|DRUG: Placebo - first 24 weeks|DRUG: Saw Palmetto - weeks 24 - 48|DRUG: Placebo - weeks 24 - 48|DRUG: Saw Palmetto - weeks 48 - 72|DRUG: Placebo - weeks 48 - 72
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Central Obesity in Cases of OAB
Status: COMPLETED
Conditions: Urologic Diseases|Overactive Bladder Syndrome|Obesity, Abdominal
Interventions: DIAGNOSTIC_TEST: visceral fat obesity (surface area and function)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Abemaciclib Plus Ramucirumab for Esophageal/Gastroesophageal Junction Ca
Status: UNKNOWN
Conditions: Metastatic Esophageal Adenocarcinoma|Metastatic Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Abemaciclib|DRUG: Ramucirumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Adductor-Canal-Blockade on High Pain Responders After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Pain After Total Knee Arthroplasty
Interventions: DRUG: Ropivacaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Andecaliximab With mFOLFOX6 as First Line Treatment for Advanced Gastric or Gastroesophageal Junction Adenocarcinoma
Status: COMPLETED
Conditions: Gastric Adenocarcinoma
Interventions: DRUG: Andecaliximab|DRUG: Placebo|DRUG: Leucovorin|DRUG: 5-fluorouracil|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Dexmedetomidine Dose-finding Study
Status: COMPLETED
Conditions: Laceration Repair
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Novel Biomarkers in Acute Kidney Injury
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: OTHER: Proteomic assay|OTHER: Blood sampling|OTHER: Biomarker sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety Assessment of Lactobacillus Salivarius CECT5713 in 6 Months Old Children
Status: COMPLETED
Conditions: Infection
Interventions: DIETARY_SUPPLEMENT: follow on formula without probiotics|DIETARY_SUPPLEMENT: follow on formula with Lactobacillus salivarius CECT5713
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Comparison of Biomarkers of Stress in Emergency Physicians Working a 24-hour Shift or a 14-hour Night Shift - the JOBSTRESS Randomized Trial
Status: COMPLETED
Conditions: Biomarkers of Stress in Emergency Physicians
Interventions: BEHAVIORAL: Comparison of biomarkers of stress
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: A Study in Healthy People to Compare Two Different Sifrol® Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pramipexole (from manufacturing site 1)|DRUG: Pramipexole (from manufacturing site 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Bimekizumab in Subjects With Active Nonradiographic Axial Spondyloarthritis
Status: COMPLETED
Conditions: Nonradiographic Axial Spondyloarthritis
Interventions: DRUG: Bimekizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Gentamicin Lavage of the Axillary Surgical Bed After Lymph Node Dissection on Drainage Discharge Volume
Status: COMPLETED
Conditions: Axillary Drainage Volume After Lymph Node Dissection.
Interventions: DRUG: Axillary lavage with gentamicin solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Epstein-Barr Virus Suppression in Chronic Obstructive Pulmonary Disease (EViSCO): a Phase 2 Randomised Control Trial
Status: TERMINATED
Conditions: COPD|EBV
Interventions: DRUG: Valaciclovir|DRUG: Placebo capsules (containing Avicel blend)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Personal Relevance of Visual Autobiographical Stimuli in Positive Emotions Induction
Status: UNKNOWN
Conditions: Emotion Regulation|Mood Induction|Autobiographical Memory|Ageing
Interventions: OTHER: Images' personal relevance effectiveness in objective and subjective mood recovery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of LY2189265 in Japanese Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: LY2189265|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Care for America's Aging Study
Status: NOT_YET_RECRUITING
Conditions: Cognitive Impairment|Dementia With Behavioral Disturbance|Dementia|Alzheimer Disease
Interventions: BEHAVIORAL: Enhanced home health aide training in dementia and dementia-related behaviors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Efficacy, Safety, and Tolerability of E2086 Compared to Placebo and Active Comparator in Adult Participants With Narcolepsy Type 1
Status: RECRUITING
Conditions: Narcolepsy Type 1 (NT1)
Interventions: DRUG: E2086|DRUG: E2086 Placebo|DRUG: Active Comparator|DRUG: Active Comparator Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prediction of Response to 2nd-line Hormone Therapy by FES CT/PET in Patients With Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DIAGNOSTIC_TEST: FES PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Determine the Pharmacokinetics and Tolerability of Fluticasone Propionate MDPI and Fluticasone Propionate/Salmeterol MDPI Compared to High Strength FLOVENT® DISKUS® and ADVAIR® DISKUS® in Patients With Persistent Asthma 12 Years of Age and Older
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Treatment A: Fp MDPI|DRUG: Treatment B: FS MDPI|DRUG: Treatment C Flovent|DRUG: Treatment D: Advair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Premixed Nitrous Oxide and Oxygen in Elderly Patient With Out-of-hospital Severe Acute Pain
Status: TERMINATED
Conditions: Pain Acute
Interventions: DRUG: Premixed 50% nitrous oxide and oxygen|DRUG: Medical Air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Safety, Tolerability, Systemic Exposure and Efficacy of GPB Cream in Adolescents With Severe Primary Hyperhidrosis
Status: COMPLETED
Conditions: Primary Axillary Hyperhidrosis
Interventions: DRUG: Glycopyrronium Bromide (GPB) Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shock Wave Therapy Versus Neuromuscular Training in Women With Patellofemoral Pain
Status: UNKNOWN
Conditions: Patellofemoral Pain Syndrome|Knee Pain Chronic
Interventions: OTHER: Neuromuscular Training|OTHER: Extracorporeal Shock Wave Therapy (ESWT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MK0462 5 mg, Sumatriptan 50 mg, and Placebo Comparison Study (0462-029)
Status: COMPLETED
Conditions: Migraine Headache
Interventions: DRUG: rizatriptan benzoate (MK0462)|DRUG: Comparator: sumatriptan|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: Ocrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Cafestol on Glucose Metabolism in Subjects With Type-2-diabetes.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DIETARY_SUPPLEMENT: Cafestol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Effectiveness of Rivaroxaban (Xarelto) Versus Low-molecular-weight Heparin (LMWH) and Phenprocoumon for the Treatment and Secondary Prevention of Venous Thromboembolism in Routine Clinical Practice in Germany
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: Rivaroxaban (Xarelto, BAY 59-7939)|DRUG: LMWH and Phenprocoumon
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Magnetic Resonance Imaging (MRI) Correlation to Standard of Care Imaging and Pathology Correlation in Breast Carcinoma
Status: TERMINATED
Conditions: Breast Neoplasms
Interventions: PROCEDURE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of ABBV-181 (Budigalimab) in Adult Participants With Human Immunodeficiency Virus (HIV)-1
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV)|HIV Infection|HIV-1
Interventions: DRUG: ABBV-181|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Surefire Infusion System vs. Standard Microcatheter Use During Holmium-166 Radioembolization
Status: UNKNOWN
Conditions: Colorectal Neoplasms|Neoplasm Metastasis|Liver Diseases|Digestive System Neoplasms
Interventions: DEVICE: Holmium-166-poly (L-lactic acid) microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Weekly Irinotecan Liposomes in Recurrent or Refractory Ewing Sarcoma
Status: RECRUITING
Conditions: Ewing Sarcoma
Interventions: DRUG: Irinotecan Hydrochloride Liposome Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: E07-001: Safety and Efficacy Extension Study of Eculizumab in Paroxysmal Nocturnal Hemoglobinuria Patients
Status: COMPLETED
Conditions: Paroxysmal Nocturnal Hemoglobinuria
Interventions: DRUG: Eculizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dehydrated Human Amnion/Chorion Membrane (dHACM) for Recovery After Fractionated Ablative CO2 Laser Resurfacing of the Face
Status: WITHDRAWN
Conditions: Scarring
Interventions: OTHER: Application of Sterile 0.9% Saline Solution|OTHER: Application of dHACM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CRD007 for the Treatment of Duchenne Muscular Dystrophy, Becker Muscular Dystrophy and Symptomatic Carriers
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy|Becker Muscular Dystrophy
Interventions: DRUG: CRD007
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: A Study of ASP1585 to Evaluate the Bioequivalence Between ASP1585 Granules and ASP1585 Capsules
Status: COMPLETED
Conditions: Healthy|Urine Phosphorus Excretion
Interventions: DRUG: ASP1585
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Bicalutamide (Casodex™) Versus Placebo in Patients With Early Prostate Cancer
Status: COMPLETED
Conditions: Non-metastatic Prostate Cancer
Interventions: DRUG: Bicalutamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bone Marrow Transplantation in Treating Patients With Hematologic Cancer
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Precancerous/Nonmalignant Condition|Small Intestine Cancer
Interventions: DRUG: cyclophosphamide|PROCEDURE: allogeneic bone marrow transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Sulindac in Preventing Melanoma in Healthy Participants Who Are at Increased Risk of Melanoma
Status: COMPLETED
Conditions: Precancerous Condition
Interventions: DRUG: sulindac|OTHER: placebo|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, and Immunogenicity of an Investigational Vaccine With Recombinant Human Albumin (rHA) in Children 12 to 18 Months of Age (V205C-009)(COMPLETED)
Status: COMPLETED
Conditions: Measles|Mumps|Rubella|Varicella
Interventions: BIOLOGICAL: measles, mumps, and rubella virus vaccine live|BIOLOGICAL: Comparator: Measles, Mumps, and Rubella Virus Vaccine Live
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study to Evaluate the Safety, Tolerability and Efficacy of IOS-1002 Administered Alone and in Combination With Pembrolizumab, a PD-1 Monoclonal Antibody in Advanced Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor, Adult
Interventions: DRUG: IOS-1002|DRUG: IOS-1002 + KEYTRUDA® (pembrolizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Instrument-Assısted Soft Tissue Mobılızatıon in Patients With Operated Distal Radius Fracture
Status: RECRUITING
Conditions: Distal Radius Fractures|Instrument-assisted Soft Tissue Mobilization
Interventions: DEVICE: Instrument-assisted soft tissue mobilization|OTHER: Routine rehabilitation programe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thoracic Spine Thrust Manipulation Compared to Sham Manipulation in Individuals With Subacromial Pain Syndrome
Status: COMPLETED
Conditions: Subacromial Impingement|Subacromial Impingement Syndrome
Interventions: PROCEDURE: Supine upper thoracic spine thrust manipulation|PROCEDURE: Seated upper thoracic spine thrust manipulation|PROCEDURE: Sham manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Preparing for Heat Waves - Enhancing Human Thermophysiological Resilience
Status: NOT_YET_RECRUITING
Conditions: Body Temperature Changes|Heat Exposure|Heat Stress|Hyperthermia
Interventions: OTHER: Heat acclimation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Gabapentin (Neurentin) and Pregabalin (Lyrica) in Pain Reduction After Photorefractive Keratectomy
Status: UNKNOWN
Conditions: Refractive Errors
Interventions: DRUG: Pregabalin|DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Comparing Standard Wound Closure Techniques Versus TissuGlu® Surgical Adhesive
Status: COMPLETED
Conditions: Disorder of Skin and/or Subcutaneous Tissue of Trunk
Interventions: DEVICE: TissuGlu Surgical Adhesive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home-based tDCS in Frontotemporal Dementia or Alzheimer's Disease
Status: ENROLLING_BY_INVITATION
Conditions: Mild Cognitive Impairment|Primary Progressive Aphasia|Dementia
Interventions: OTHER: Computerized Cognitive Training via BrainHQ|DEVICE: Active tDCS (tDCS) on DLPFC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Test of Virtual Reality Obstacle Detection for Low Vision Walking
Status: RECRUITING
Conditions: Hemianopsia|Homonymous Hemianopia|Tunnel Vision|Visual Field Defect, Peripheral|Visual Field Constriction Bilateral|Visual Field Defect Homonymous Bilateral
Interventions: OTHER: Field expansion view
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Physiologic Pacing for Symptomatic First-Degree Heart Block
Status: RECRUITING
Conditions: Symptomatic First-degree Heart Block
Interventions: DEVICE: Dual chamber Medtronic pacemaker implantation.|OTHER: DDD-50 pacing program|OTHER: AAI-DDD 50 pacing program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sodium Hyaluronate Injection and Corticosteroids in Trochanteric Bursitis: a Randomized Controlled Study.
Status: UNKNOWN
Conditions: Osteoarthritis
Interventions: DRUG: Corticosteroids|DEVICE: Hyaluronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fondaparinux as Monotherapy for DVT and/or Pulmonary Embolism
Status: COMPLETED
Conditions: Deep Vein Thrombosis|Pulmonary Embolism
Interventions: DRUG: Fondaparinux
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Activity of Sparsentan for the Treatment of Incident Patients With Immunoglobulin A Nephropathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Immunoglobulin A Nephropathy|Kidney Diseases|Glomerulonephritis, IGA|Glomerulonephritis|Autoimmune Diseases|Immune System Diseases
Interventions: DRUG: Sparsentan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Mechanisms of Reducing Polysubstance Use Following a Novel Body-mind Intervention
Status: COMPLETED
Conditions: Multiple Drug Use
Interventions: BEHAVIORAL: IBMT|BEHAVIORAL: RT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis With or Without the Presence of Nasal Polyps
Status: COMPLETED
Conditions: Chronic Rhinosinusitis
Interventions: DRUG: OPN-375
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT