pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Clinical Study of CLDN18.2-targeting CAR T Cells in Advanced Solid Tumors With Positive CLDN18.2 Expression
Status: RECRUITING
Conditions: Gastric Cancer|Pancreatic Cancer|Advanced Ovarian Carcinoma|Gastroesophageal Junction Adenocarcinoma
Interventions: BIOLOGICAL: Claudin 18.2 CAR-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Respiratory Tele-rehabilitation After COVID-19 Pneumonia Related: a Randomized Controlled Trial
Status: UNKNOWN
Conditions: Respiratory Failure|Sars-CoV-2|Covid19|ARDS|Interstitial Pneumonia|Respiratory Rehabilitation|Dyspnea|Quality of Life|Coronavirus Infections
Interventions: OTHER: Telerehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Switching From Stavudine or Zidovudine to Tenofovir DF in HIV-1 Infected Children
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Tenofovir DF|DRUG: Zidovudine|DRUG: Stavudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Combination Chemotherapy With Aflibercept in Patients With Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: AFLIBERCEPT|DRUG: Irinotecan|DRUG: 5-Fluorouracil|DRUG: Folinic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Combination HDI and Anti-CTLA4 for Recurrent Inoperable Stage III or Stage IV Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Anti-CTLA4 monoclonal antibody and HDI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Evaluate Safety and Immunogenicity of Sub-unit Adjuvanted Influenza Vaccine Administered to Elderly Subjects, Formulation 2011-2012
Status: COMPLETED
Conditions: Seasonal Influenza
Interventions: BIOLOGICAL: Seasonal Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: STAR-AF:Substrate Versus Trigger Ablation for Reduction of Atrial Fibrillation Trial
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Ablate AF triggers via PVI|PROCEDURE: Substrate via CFAEs|PROCEDURE: Combined approach for AF ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Marine Protein Hydrolysate as Dietary Supplement in Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: MPH_active|DIETARY_SUPPLEMENT: MPH_placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Do Angiotensin Receptor Blockers Mitigate Progression to Acute Respiratory Distress Syndrome With SARS-CoV-2 Infection
Status: COMPLETED
Conditions: SARS-CoV Infection
Interventions: DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Open Label Study of NVP+CBV Treatment in Women Who Have Received sdNVP for the pMTCT of HIV
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome
Interventions: DRUG: Nevirapine|DRUG: Zidovudine|DRUG: 3TC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors
Status: COMPLETED
Conditions: Breast Cancer|Gestational Trophoblastic Tumor|Kidney Cancer|Lymphoma|Neuroblastoma|Ovarian Cancer|Sarcoma|Testicular Germ Cell Tumor
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: recombinant interleukin-11
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Prophylactic Intravesical Chemotherapy to Prevent Bladder Recurrence After Nephroureterectomy for Primary Upper Tract Urothelial Carcinoma Patients
Status: UNKNOWN
Conditions: Bladder Recurrence|Upper Tract Urothelial Carcinoma|Nephroureterectomy
Interventions: DRUG: Pirarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Liking Adaptation to Beverages With Varying Sweetness Levels After Prolonged Exposure
Status: COMPLETED
Conditions: Sweetness Liking Adaptation
Interventions: OTHER: Flavored carbonated soft drink (CSD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized, Double-Blind, Placebo Controlled Study of the Short Term Clinical Effects of Tolvaptan in Patients Hospitalized for Worsening Heart Failure With Challenging Volume Management
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Tolvaptan or Samsca|DRUG: placebo or sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Placebo-Controlled Study to Investigate the Efficacy & Safety of Injectafer in the Treatment of RLS
Status: COMPLETED
Conditions: Restless Legs Syndrome (RLS)
Interventions: DRUG: Injectafer|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence and Safety Study of IN-A012 and Akynzeo Capsules in Male and Female Healthy Korean Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: IN-A012|DRUG: Akynzeo 300Mg-0.5Mg Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TAD in Primary Breast Cancer With Initially ≥ 3 Suspicious Lymph Nodes
Status: RECRUITING
Conditions: Breast Cancer|Node-positive Breast Cancer
Interventions: PROCEDURE: Targeted axilllary dissection (TAD) followed by axillary lymph node dissection (ALND)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: B. Lactis B94 Effects of Gastrointestinal Function
Status: COMPLETED
Conditions: Quality of Life
Interventions: DIETARY_SUPPLEMENT: B. lactis B94|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: An Investigation of the Metal Concentration in Patients Implanted With the PRESTIGE LP™ Cervical Disc at Two Contiguous Levels in the Cervical Spine
Status: TERMINATED
Conditions: Cervical Degenerative Disc Disease|Radiculopathy|Myelopathy
Interventions: DEVICE: PRESTIGE LP™ Cervical Disc
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Lornoxicam or Placebo for Acute Treatment of the Headache of Migraine.
Status: COMPLETED
Conditions: Headache (Migraine)
Interventions: DRUG: Lornoxicam 8 mg|DRUG: Lornoxicam 16 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Efficacy of Roxadustat in the Treatment of Heart Failure With Chronic Kidney Disease and Anemia
Status: NOT_YET_RECRUITING
Conditions: Heart Failure|Chronic Kidney Diseases|Anemia
Interventions: DRUG: Roxadustat|DRUG: Recombinant human eythropoietin and/or Iron agents
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation of Lactating Mothers
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: cholecalciferol|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Comparing Orteronel Plus Prednisone in Participants With Metastatic Castration-Resistant Prostate Cancer.
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Orteronel|DRUG: Prednisone|DRUG: Orteronel Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Genetic Testing in Predicting Biomarkers of Recurrence in Patients With Prostate Cancer Undergoing Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: GENETIC: DNA analysis|GENETIC: DNA methylation analysis|GENETIC: RNA analysis|GENETIC: gene expression analysis|GENETIC: polymerase chain reaction|OTHER: diagnostic laboratory biomarker analysis|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study Evaluating Safety and Immunogenicity of 13-Valent Pneumococcal Conjugate Vaccine With Influenza Vaccine in Adults
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: 13-valent pneumococcal conjugate vaccine|BIOLOGICAL: 13vPnC + TIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Romosozumab to Improve Bone Mineral Density and Architecture in Chronic SCI
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Cord Injury (=3 Years)|Sublesional Bone Loss Secondary to SCI
Interventions: DRUG: Romosozumab|DRUG: Denosumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Products Containing Marine Collagen Peptide and Coenzyme Q10 for Skin Rejuvenation
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Placebo|OTHER: Product containing marine collagen peptide and Coenzyme Q10.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Impact of Co Enzyme Q10 as Adjuvant Therapy to Letrozole on Spermiogram
Status: COMPLETED
Conditions: Male Reproductive Problem|Infertility, Male
Interventions: DRUG: Letrozole tablets|DIETARY_SUPPLEMENT: Coenzyme Q10 table
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CNS10-NPC-GDNF Delivered to the Motor Cortex for ALS
Status: RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: BIOLOGICAL: CNS10-NPC-GDNF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: APEX Study: Effects of Allopurinol on Coronary and Peripheral Endothelial Function in Patients With Cardiac Syndrome X
Status: COMPLETED
Conditions: Syndrome X
Interventions: DRUG: allopurinol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Two-dose Primary Vaccination Study of a Tetravalent Dengue Virus Purified Inactivated Vaccine vs. Placebo in Healthy Adults (in Puerto Rico)
Status: COMPLETED
Conditions: Dengue Fever
Interventions: BIOLOGICAL: Biological/Vaccine: 4 µg TDENV-PIV with Alum adjuvant|BIOLOGICAL: Biological/Vaccine: 1 µg TDENV-PIV with AS03B adjuvant|OTHER: Phosphate buffered saline|BIOLOGICAL: 1 µg TDENV-PIV with Alum adjuvant|BIOLOGICAL: 1 µg TDENV-PIV with AS01E adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nivolumab Combined With Chemoradiotherapy Sparing Concurrent Cisplatin in Nasopharyngeal Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: PD-1 blocking antibody|DRUG: Gemcitabine|DRUG: Cisplatin|RADIATION: Intensity-modulated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Comparative Trial for Persistent Pain in Spinal Cord Injury: Acupuncture vs Aspecific Needle Skin Stimulation
Status: TERMINATED
Conditions: Pain|Spinal Cord Injuries
Interventions: OTHER: Traditional chinese acupuncture|OTHER: Aspecific needle skin stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Sensorimotor Compatibility Effects in Bipolar Affective Disorder.
Status: COMPLETED
Conditions: Bipolar Affective Disorder
Interventions: BEHAVIORAL: cognitive tasks + IQ + MINI|BEHAVIORAL: cognitive tasks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Study Comparing Endeavor With Cypher Stents (PROTECT)
Status: COMPLETED
Conditions: Ischemic Heart Disease
Interventions: DEVICE: Stent|DEVICE: Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections
Status: COMPLETED
Conditions: Bacterial Infections
Interventions: DRUG: ceftaroline|DRUG: vancomycin plus aztreonam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Mate Extracts on Decrement of Body and Abdominal Fat in Obese Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Mate extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of a Couple-Focused mHealth Symptom Self-management Program
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BEHAVIORAL: Prostate Cancer Education and Resources for Couples (PERC)|BEHAVIORAL: usual care plus NCI website
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: NKG2D CAR-NK Cell Therapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Safety and Efficacy
Interventions: BIOLOGICAL: CAR-NK cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Human Leukocyte Antigen Macthing on Guiding Tacrolimus Regimen After Liver Transplantation
Status: NOT_YET_RECRUITING
Conditions: Liver Transplantation|Graft Versus Host Disease|Graft Rejection|Drug-Related Side Effects and Adverse Reactions
Interventions: OTHER: tacrolimus regimen guided by HLA matching rate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study to Assess OZURDEX® in Patients With Macular Oedema Secondary to Retinal Vein Occlusion (RVO)
Status: COMPLETED
Conditions: Macular Edema|Retinal Vein Occlusion
Interventions: DRUG: dexamethasone 700 ug intravitreal implant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of "Treat-and-Extend" Regimen Versus "Pro Re Nata" of Conbercept in Age-related Macular Degeneration
Status: UNKNOWN
Conditions: Age-related Macular Degeneration
Interventions: PROCEDURE: Treat-and-Extend regimen|PROCEDURE: Pro Re Nata|DRUG: Conbercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NKT Role in the Regulation of the Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|Primary Sclerosing Cholangitis
Interventions: OTHER: collection of gut biopsies collection of blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Early Rheumatoid Arthritis COR Intervention
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Cardiovascular Diseases
Interventions: OTHER: Simvastatin|OTHER: Losartan|OTHER: Losartan|OTHER: Losartan|OTHER: Metformin|OTHER: Outpatient rheumatology department|OTHER: Refered to general practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Predicting Outcome of Cytoreduction in Advanced Ovarian Cancer, Using a Machine Learning Algorithm and Patterns of Disease Distribution at Laparoscopy (PREDAtOOR)
Status: NOT_YET_RECRUITING
Conditions: Ovarian Cancer Stage III|Ovarian Cancer Stage IV
Interventions: DIAGNOSTIC_TEST: Artificial Intelligence
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Transcranial Magnetic Stimulation for Depression in Autism Spectrum Conditions
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Major Depressive Disorder
Interventions: PROCEDURE: Bilateral TMS|PROCEDURE: Unilateral TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epigenetic Modulation in Relapsed/Refractory Follicular Lymphoma and Marginal Zone Lymphoma
Status: TERMINATED
Conditions: Follicular Lymphoma|Marginal Zone Lymphoma
Interventions: DRUG: azacitidine|DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MoodUP in Improving Psychological Outcomes Among Perinatal Women
Status: RECRUITING
Conditions: Anxiety|Pregnancy Related|Perinatal Depression|Prenatal Stress|Sleep Disturbance
Interventions: BEHAVIORAL: Internet-based Cognitive Behavioural Therapy|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Does an Integrative Neuro-psychotherapy Program Foster the Adjustment in Depressed Stroke Patients? A Randomized Controlled Study.
Status: TERMINATED
Conditions: Adjustment Disorders|Non-progressive Brain Injury
Interventions: BEHAVIORAL: Neuropsychological Therapy, cognitive behavioral therapy, solution focused therapy|BEHAVIORAL: Integrative Neuro-Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Effectiveness of HBY 097 Used With or Without AZT in HIV-Infected Patients Who Have Mild or No Symptoms
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: HBY 097|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Phase 3b Study of Ivosidenib in Combination With Azacitidine in Adult Patients Newly Diagnosed With IDH1m Acute Myeloid Leukemia (AML) Ineligible for Intensive Induction Chemotherapy.
Status: RECRUITING
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: Ivosidenib 500mg Oral Tablet|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept and Dose-ranging Study of INDV-2000 in Individuals With Moderate to Severe Opioid Use Disorder
Status: RECRUITING
Conditions: Opioid Use Disorder
Interventions: DRUG: INDV-2000|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Demonstrate the Bioequivalence of Sitagliptin/Metformin Combination Tablets and Concomitant Administration of Sitagliptin and Metformin as Individual Tablets (0431A-048)
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: sitagliptin phosphate (+) metformin hydrochloride|DRUG: Comparator: metformin 500 mg|DRUG: Comparator: sitagliptin|DRUG: Comparator: FMI sitagliptin/metformin 50 mg/500 mg FDC tablet|DRUG: Comparator: FMI sitagliptin/metformin 50 mg/1000 mg FDC tablet|DRUG: Comparator: metformin 1000 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation
Status: NOT_YET_RECRUITING
Conditions: Overweight or Obesity|Atrial Fibrillation
Interventions: DRUG: Semaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a Booster Dose of GlaxoSmithKline (GSK) Biologicals' Hepatitis B Vaccine
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Engerix™-B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Cholesterol Lowering Therapy of Focused Power Ultrasound Mediated Perirenal Fat Ablation
Status: COMPLETED
Conditions: Visceral Obesity|Ultrasound Therapy|Dyslipidemias
Interventions: DEVICE: focused power ultrasound treatment|DEVICE: Sham treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Iloprost on Pulmonary Hemodynamics and Oxygenation in Patients of Chronic Obstructive Pulmonary Disease During One-lung Ventilation
Status: COMPLETED
Conditions: Video-assisted Thoracoscopic Surgery|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Inhaled iloprost|DRUG: normal saline (Saline 0.9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Study Comparing Two Fluticasone Furoate Nasal Sprays in the Relief of the Signs and Symptoms of Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal
Interventions: DRUG: Fluticasone furoate 27.5 mcg/actuation nasal spray (Lek Pharmaceuticals)|DRUG: Fluticasone furoate (Veramyst®) 27.5 mcg/actuation nasal spray|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Afamelanotide and Narrow-Band Ultraviolet B (NB-UVB) Phototherapy in the Treatment of Nonsegmental Vitiligo (NSV)
Status: COMPLETED
Conditions: Vitiligo
Interventions: DRUG: Afamelanotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary
Status: COMPLETED
Conditions: Malignant Ovarian Epithelial Tumor|Ovarian Granulosa Cell Tumor|Ovarian Gynandroblastoma|Ovarian Sertoli-Leydig Cell Tumor|Ovarian Sex Cord Tumor With Annular Tubules|Ovarian Sex Cord-Stromal Tumor|Ovarian Sex Cord-Stromal Tumor of Mixed or Unclassified Cell Types|Ovarian Steroid Cell Tumor
Interventions: BIOLOGICAL: Bevacizumab|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Differential Effects of rhGH vs. rhIGF-1 on Cardiovascular Risk Factors
Status: TERMINATED
Conditions: Growth Hormone Deficiency
Interventions: DRUG: Recombinant Human Growth Hormone|DRUG: Recombinant Human IGF-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: To Evaluate the Therapeutic Equivalence and Safety in Treatment of Scalp Psoriasis
Status: COMPLETED
Conditions: Scalp Psoriasis
Interventions: DRUG: Betamethasone Scalp Suspension 0.064%;0.0005%|DRUG: Taclonex®|DRUG: Placebo topical suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Multispecies Probiotic Ecologic 825 Versus Placebo in Ulcerative Colitis Patients
Status: SUSPENDED
Conditions: Ulcerative Colitis
Interventions: DIETARY_SUPPLEMENT: Ecologic 825|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Single-dose Study in Paediatric Patients Aged 2 to Less Than 18 Years With Secondary Hyperparathyroidism (sHPT) Receiving Haemodialysis
Status: COMPLETED
Conditions: Chronic Kidney Disease, Secondary Hyperparathyroidism
Interventions: DRUG: Etelcalcetide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients
Status: COMPLETED
Conditions: Neurological Diseases|Pneumopathy|Major Abdominal Surgery|Acute Pancreatitis
Interventions: DIETARY_SUPPLEMENT: Crucial (enteral tube feeding)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Toothbrushing Techniques in Plaque Removal and Caries Lesion Control
Status: COMPLETED
Conditions: Caries
Interventions: BEHAVIORAL: modified toothbrush with multilevel filaments|BEHAVIORAL: cross toothbrushing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Telemonitoring of Treatment Effects in Connective Tissue Disease-associated Interstitial Lung Disease (TEL-CTD-ILD)
Status: UNKNOWN
Conditions: Connective Tissue Disease-associated Interstitial Lung Disease|Interstitial Lung Disease|Connective Tissue Diseases
Interventions: OTHER: Telemonitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Feasability Study of Autologous Bone Marrow Aspirate Concentrate for Treatment of CLI
Status: COMPLETED
Conditions: Arterial Occlusive Diseases
Interventions: DEVICE: centrifuge, laboratory, tabletop (SmartPReP2 BMAC System)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Could Self-distancing Alter the Perception of Experimental Pain?
Status: UNKNOWN
Conditions: Pain, Experimental
Interventions: BEHAVIORAL: Self-distancing, third-person self-talk.|BEHAVIORAL: Self-immersed, first-person self-talk.|BEHAVIORAL: Distraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Egalet-002 in Patients With Moderate-to-Severe Chronic Low Back Pain
Status: COMPLETED
Conditions: Moderate-to-severe Chronic Low Back Pain
Interventions: DRUG: Oxycodone extended-release|DRUG: Placebo of oxycodone extended-release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Pharmacogenetic Testing and Clinical Outcomes in Patients With Early-Phase Psychosis
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder|Psychotic Disorders|Bipolar Disorder
Interventions: BIOLOGICAL: PGx testing guided treatment (PGT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparing Perclose to Statseal in Conjunction With Perclose in Femoral 6 French Arteriotomy Closure
Status: RECRUITING
Conditions: Arterial Occlusion|Cardiovascular Diseases|Atherosclerosis|Hematoma
Interventions: DEVICE: Perclose|DRUG: Statseal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irinotecan, Vincristine, and Dexamethasone In Children With Relapsed And/Or Refractory Hematologic Malignancies
Status: COMPLETED
Conditions: Non-Hodgkins Lymphoma|Hodgkin's Disease|Acute Lymphoblastic Leukemia
Interventions: DRUG: Dexamethasone|DRUG: Irinotecan|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy Plus Panitumumab Compared to Chemoradiotherapy With Unresected, Locally Advanced Squamous Cell Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Cancer|Head and Neck Cancer|Oncology|Squamous Cell Carcinoma
Interventions: DRUG: Panitumumab|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Tegaserod on Mechanical Sensitivity of the Esophagus and Stomach in Patients With Heartburn and Dyspepsia.
Status: COMPLETED
Conditions: Heartburn|Dyspepsia
Interventions: DRUG: Tegaserod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Observe and Evaluate the Safety and Efficacy of T60c Injection for Treatment of Advanced Solid Tumor Patients
Status: NOT_YET_RECRUITING
Conditions: Malignant Solid Tumors
Interventions: DRUG: T60c injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PrEPared-RN, CAN Nurse-Led Management of High-risk Patients for Pre-Exposure Prophylaxis (PrEP)
Status: RECRUITING
Conditions: Hiv Prevention|Pre-Exposure Prophylaxis (PrEP)
Interventions: DRUG: Truvada
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combined Ketamine/Propofol for Emergency Department Procedural Sedation
Status: TERMINATED
Conditions: Procedural Sedation and Analgesia
Interventions: DRUG: Ketamine|DRUG: Placebo|DRUG: Fentanyl|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study of Ciprofloxacin Plus Fluocinolone in Acute Otitis Externa (AOE)
Status: UNKNOWN
Conditions: Acute Otitis Externa
Interventions: DRUG: Ciprofloxacin-Fluocinolone Acetonide, 0.3%-0.025% Otic Solution|DRUG: Ciprofloxacin 0.3% solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neihulizumab (ALTB-168) in Patients With Steroid-refractory Acute Graft-versus-host Disease or Treatment-refractory Acute Graft-versus-host Disease
Status: COMPLETED
Conditions: Steroid-refractory Acute Graft-versus-Host Disease|Treatment-refractory Acute Graft-versus-Host Disease
Interventions: BIOLOGICAL: Neihulizumab (ALTB-168)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telerehabilitation in Patients With Fibrosing Interstitial Lung Diseases
Status: RECRUITING
Conditions: Fibrosing Interstitial Lung Disease|Telerehabilitation
Interventions: OTHER: Synchronized online telerehabilitation exercise program|OTHER: Videobased telerehabilitation exercise program|OTHER: Hospital based outpatient exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug-coated Balloon Angioplasty for Patients With Symptomatic Vertebral Artery Stenosis
Status: UNKNOWN
Conditions: Vertebral Artery Stenosis
Interventions: DEVICE: Drug-coated balloon angioplasty|DEVICE: stenting angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Polymerase Chain Reaction in the Management of Patients With Infective Endocarditis
Status: RECRUITING
Conditions: Endocarditis Infective
Interventions: DIAGNOSTIC_TEST: PCR (Polymerase Chain Reaction) targeting the 16 ribosomal DNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Highly Cross-Linked and Conventional Polyethylene in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: Total knee arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Epiduroscopy and Ozone Therapy in Patients With Failed Back Surgery Syndrome
Status: COMPLETED
Conditions: Low Back Pain|Failed Back Surgery Syndrome
Interventions: PROCEDURE: Epiduroscopy with oxygen therapy|PROCEDURE: Epiduroscopy with ozone therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 4 Study of Greenlight XPS Laser Versus BiVAP Saline Vaporization of the Prostate in Men With Symptomatic Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia (BPH)
Interventions: DEVICE: Greenlight XPS Laser|DEVICE: BiVAP Saline Vaporization of the prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Pharmacodynamic and Pharmacokinetic Interactions of Tasimelteon and Ethanol
Status: COMPLETED
Conditions: Pharmacodyamics and Pharmacokinetics of Tasimelteon Alone and in Combination With Ethanol
Interventions: DRUG: tasimelteon|DRUG: Ethanol|OTHER: Placebo tasimelteon|DRUG: Placebo ethanol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Video Camera Monitoring Feedback on Hand Hygiene Compliance and Infections in NICU
Status: COMPLETED
Conditions: Healthcare Associated Infection|Hand Hygiene|Neonatal Infection
Interventions: OTHER: Hand hygiene compliance observation with video camera surveillance system and performance feedback of the HH rates to HCWs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Comprehensive Care Protocol in New Diagnosis of Type 2 Diabetes Mellitus and Associated Comorbidities in Primary Care
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: OTHER: Comprehensive care protocol in new diagnosis of Type 2 Diabetes Mellitus and associated comorbidities in Primary Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Reduced-dose RT With/Without CCT Versus Standard CCRT for High-risk LANPC Who Achieved CR Post Induction Chemotherapy
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma|De-escalation Therapy
Interventions: DRUG: Cisplatin-based induction chemotherapy|DRUG: Full course of PD-1/PD-L1 blockades|RADIATION: Reduced-dose IMRT|RADIATION: Standard-dose IMRT|DRUG: Concurrent Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Cash Transfer Program in Low-Income Families in Guinea-Bissau
Status: UNKNOWN
Conditions: Per Capita Food Consumption Expenditure|Childhood Growth|Childhood Cognition|Anemia|School Registration and Attendence|Diabetes
Interventions: BEHAVIORAL: Cash Transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Anti-CXCR4 (BMS-936564) Alone and in Combination With Lenalidomide/Dexamethasone or Bortezomib/Dexamethasone in Relapsed/Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: Anti-CXCR4 (BMS-936564)|BIOLOGICAL: Lenalidomide|BIOLOGICAL: Dexamethasone|BIOLOGICAL: Anti-CXCR4 (BMS-936564)|BIOLOGICAL: Bortezomib|BIOLOGICAL: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Aliskiren Administered in Combination With Amlodipine Versus Amlodipine Alone in African American Patients With Stage 2 Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Aliskiren/Amlodipine|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Corneal Crosslinking Using the PXL-Platinum 330 for Eyes With Corneal Ectatic Conditions
Status: TERMINATED
Conditions: Keratoconus|Cornea Ectasia
Interventions: COMBINATION_PRODUCT: Epithelial-on Corneal Crosslinking with the PXL 330 Platinum system.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Consistency Between Innovative Methods for Measuring the Area and Depth of Pressure Injuries
Status: COMPLETED
Conditions: Pressure Injury|Innovativeness|Wound
Interventions: DEVICE: eKare Insight, imitoMeasure Mobile App, Visitrak
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety of a Booster Dose of GlaxoSmithKline (GSK) Biologicals' Boostrix™ Vaccine in Healthy Vietnamese Children
Status: COMPLETED
Conditions: Diphtheria|Tetanus|Acellular Pertussis
Interventions: BIOLOGICAL: Boostrix™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Intra-patient Comparison of Closed Loop and Plate Haptic Toric Intraocular Lenses
Status: UNKNOWN
Conditions: Cataract
Interventions: DEVICE: T-flex Aspheric Toric IOL|DEVICE: AT TORBI toric IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study Evaluating the Safety and Efficacy of ZRMT Regimen in the Treatment of PCNSL
Status: RECRUITING
Conditions: Primary Central Nervous System Lymphoma
Interventions: DRUG: zanubrutinib 160 mg BID orally
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRISM: Efficacy and Safety of Cobomarsen (MRG-106) in Subjects With Mycosis Fungoides Who Have Completed the SOLAR Study
Status: TERMINATED
Conditions: Cutaneous T-Cell Lymphoma/Mycosis Fungoides
Interventions: DRUG: Cobomarsen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Pulsed Taxol With Concurrent Thoracic Radiotherapy, & Adjuvant Chemo in Stage III NSCLC
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Taxol (paclitaxel)|PROCEDURE: Radiotherapy|DRUG: Carboplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxytocin Pharmacokinetics and Pharmacodynamics
Status: NOT_YET_RECRUITING
Conditions: Post Partum Hemorrhage|Cesarean Section Complications|Blood Loss
Interventions: DRUG: deuterated oxytocin (d5OT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prophylactic vs Therapeutic Cerebrospinal Fluid Drain Placement During Endovascular Thoracoabdominal Aortic Aneurysm Repair
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Cord Ischemia
Interventions: PROCEDURE: Cerebrospinal Fluid Drain Placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A First-in-Human Study Evaluating AGA2118 in Men and Postmenopausal Women
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: AGA2118|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of an Inactivated COVID-19 Vaccine in Patients Aged ≥60 Years With Chronic Bronchitis and COPD
Status: UNKNOWN
Conditions: COVID-19|Chronic Bronchitis|Copd
Interventions: BIOLOGICAL: Inactivated COVID-19 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Beta-blockers for Prevention Of Growth Of Small Esophageal Varices In Cirrhosis: An Randomized Controlled Trial (RCT)
Status: COMPLETED
Conditions: Cirrhosis
Interventions: DRUG: Propranolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of add-on Ramelteon Therapy on Sleep and Circadian Rhythm Disruption in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Risperidone|DRUG: Risperidone and Ramelteon|DRUG: Haloperidol|DRUG: Haloperidol and Ramelteon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety Follow-up of Subjects With Giant Cell Tumor of Bone Treated With Denosumab in Study 20062004
Status: COMPLETED
Conditions: Giant Cell Tumor of Bone
Interventions: DRUG: Denosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacodynamic Bioequivalence of Metered Dose Inhalers of Albuterol Sulfate in Patients With Stable Mild Asthma
Status: COMPLETED
Conditions: Mild Persistent Asthma
Interventions: OTHER: methacholine chloride|DRUG: placebo ProAir HFA|DRUG: ProAir HFA|DRUG: Lupin albuterol HFA MDI|DRUG: placebo Lupin albuterol HFA MDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ivabradine to Reduce Heart Rate Prior to Coronary CT-angiography in Advanced Heart Failure: Comparison With β-Blocker
Status: UNKNOWN
Conditions: Heart Failure|CT Angiography|Ischemic Cardiomyopathy|Non-ischemic Cardiomyopathy|Heart Failure, Systolic|Heart Failure，Congestive|Heart Failure, Diastolic|Heart Rate Low
Interventions: DRUG: Ivabradine|DRUG: Metoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Study of Non-curative Resection Plus Radiotherapy After Endoscopic ESD for Superficial Esophageal Squamous Cell Carcinoma
Status: ENROLLING_BY_INVITATION
Conditions: Esophagus Cancer|Radiotherapy|Endoscopic Mucosal Resection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Antioxidant and Skin Beauty Effects of Cherry Collagen Drink
Status: COMPLETED
Conditions: Skin Condition
Interventions: DIETARY_SUPPLEMENT: Cherry collagen drink|DIETARY_SUPPLEMENT: Placebo drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Prophylactic Infusion of Calcium Gluconate Reducing the Rate of Hypocalcaemia After Total Thyroidectomy
Status: UNKNOWN
Conditions: Hypocalcemia
Interventions: DRUG: Calcium Gluconate|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Non Grafted Maxillary Sinus Floor Elevation With Implant Placement Versus the Use of Short Endosseous Implants
Status: UNKNOWN
Conditions: Primary Stability of Implants|Marginal Bone Loss
Interventions: PROCEDURE: Non grafted maxillary sinus floor elevation with simultaneous implant placement|PROCEDURE: using short dental implants for posterior atrophic maxilla
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Dexmedetomidine as Adjunct to Pudendal Block for Pediatric Penile Surgery
Status: COMPLETED
Conditions: Elective Penile Surgeries|Hypospadias|Urethral Fistula or Stricture After Hypospadias Repair|Penile Curvature
Interventions: DRUG: Dexmedetomidine|DRUG: plain ropivacaine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE