pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Alpha-Stim AID and Major Depressive Disorder
Status: UNKNOWN
Conditions: Depressive Disorder, Major
Interventions: DEVICE: Active Alpha-Stim CES|DEVICE: Sham Alpha-Stim CES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Research Study Examining the Use of Olanzapine for the Prevention of Migraine
Status: TERMINATED
Conditions: Migraine
Interventions: DRUG: Olanzapine during first intervention period and placebo during second intervention period|DRUG: Placebo during first intervention period, then olanzapine during second intervention period
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Azacytidine Combined With Lenalidomide As Maintenance Therapy Based on MRD Monitoring in AML
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia in Remission
Interventions: DRUG: Azacitidine|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maintenance Oral Etoposide or Observation Following High-dose Chemo for GCT
Status: RECRUITING
Conditions: Germ Cell Tumor|Non-seminomatous Germ Cell Tumor|Ovarian Germ Cell Tumor
Interventions: DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exenatide Compared With Twice-Daily Biphasic Insulin Aspart in Patients With Type 2 Diabetes Using Sulfonylurea and Metformin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: exenatide|DRUG: biphasic insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Daily vs. Non-Daily SBRT for NSCLC
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: RADIATION: Daily Stereotactic Body Radiotherapy|RADIATION: Non-Daily Stereotactic Body Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega-3 and Vitamin D Supplementation in Breast Cancer Women
Status: COMPLETED
Conditions: Breast Cancer Female
Interventions: DIETARY_SUPPLEMENT: Omega-3 FA|DIETARY_SUPPLEMENT: Vitamin D|COMBINATION_PRODUCT: Combined Omega-3 and Vitamin D Supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of IBI302 Injection in nAMD or DME
Status: SUSPENDED
Conditions: Neovascular Age-related Macular Degeneration|Diabetic Macular Edema
Interventions: BIOLOGICAL: Intravitreal injection of IBI302(dose 1)|BIOLOGICAL: Intravitreal injection of IBI302(dose 2)|BIOLOGICAL: Intravitreal injection of IBI302(dose 3)|DRUG: Intravitreal injection of Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SHR0302 and Steroid as First Line Therapy for Chronic GVHD
Status: RECRUITING
Conditions: Chronic GVHD
Interventions: DRUG: SHR0302|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Calcipotriol Betamethasone Plus Calcipotriol in Sequential Therapy to Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Calcipotriol Betamethasone ointment and Calcipotriol ointment|DRUG: Calcipotriol Betamethasone ointment|DRUG: Calcipotriol Betamethasone ointment and Urea Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Belantamab Mafodotin, Pomalidomide and Dexamethasone for the Treatment of High-Risk Myeloma
Status: RECRUITING
Conditions: Plasma Cell Myeloma
Interventions: BIOLOGICAL: Belantamab Mafodotin|DRUG: Dexamethasone|DRUG: Pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic/Robotic-assisted Hysteropexy Versus Vaginal Hysterectomy for the Treatment of Uterovaginal Prolapse
Status: UNKNOWN
Conditions: Uterovaginal Prolapse|Hysteropexy
Interventions: PROCEDURE: patient who undergo laparoscopic/robotic-assisted hysteropexy|PROCEDURE: patient who undergo vaginal hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Dacomitinib and Osimertinib for Patients With Advanced EGFR Mutant Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Non-small Cell Lung Cancer
Interventions: DRUG: Dacomitinib|DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimal Invasive Laser Hemorrhoidoplasty vs Conventional Excisional Hemorrhoidectomy in II-III Grade Hemorrhoidal Disease
Status: COMPLETED
Conditions: Hemorrhoids
Interventions: PROCEDURE: LHP|PROCEDURE: MM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Feasibility Trial Protocol of Metformin in Infants After Perinatal Brain Injury
Status: NOT_YET_RECRUITING
Conditions: Hypoxic-Ischemic Encephalopathy|HIE|Neurodevelopment|Infant Development
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Calcifediol Supplementation in Asthma Control in Asthmatic Patients With Vitamin D Deficiency (ACViD)
Status: COMPLETED
Conditions: Asthma, Bronchial
Interventions: DRUG: Calcifediol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate THR-149 Treatment for Diabetic Macular Oedema
Status: COMPLETED
Conditions: Diabetes Mellitus|Diabetic Retinopathy|Diabetic Macular Edema
Interventions: DRUG: THR-149 dose level 1|DRUG: THR-149 dose level 2|DRUG: THR-149 dose level 3|DRUG: THR-149 0.13mg|DRUG: THR-149 0.13mg + aflibercept 2mg|DRUG: aflibercept 2mg + THR-149 0.13mg|DRUG: Aflibercept 2mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Immunogenicity, Pharmacokinetics, and Pharmacodynamics of AMG 592 in Healthy Participants
Status: COMPLETED
Conditions: Chronic Graft-versus-host Disease (cGVHD)
Interventions: DRUG: AMG 592|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Use of the Medtronic Pump and Codman Catheter to Give Chemotherapy to Patients With Colorectal Carcinoma or Cholangiocarcinoma
Status: COMPLETED
Conditions: Colorectal Cancer|Cholangiocarcinoma
Interventions: DEVICE: Medtronic pump and Codman catheter|DRUG: Floxuridine (FUDR)|DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Irinotecan (CPT-11)|DRUG: Fluorouracil|DRUG: Anti-EGFR (Panitumumab or Cetuximab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pain, Why Still in Hospital and DAOH Following TORS for SCCUP & OSAS
Status: COMPLETED
Conditions: Analgesia|Surgery|Cancer of Head and Neck|Oropharyngeal Cancer|Carcinoma of Unknown Primary|Pain, Postoperative|Postoperative Pain
Interventions: DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 68Ga-HTK03149 for Use as a Diagnostic Radiopharmaceutical
Status: UNKNOWN
Conditions: Prostate Cancer|Prostatic Neoplasm|Prostatic Disease|Urogenital Neoplasms|Disease Attributes|Neoplasms
Interventions: OTHER: [68Ga]Ga-HTK03149 PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis
Status: COMPLETED
Conditions: Primary Sclerosing Cholangitis
Interventions: DRUG: ursodeoxycholic acid (UDCA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Palbociclib With Endocrine Therapy vs. Capecitabine in HR+/HER2- MBC With Resistance to Aromatase Inhibitors
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Palbociclib|DRUG: Capecitabine|DRUG: Exemestane|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Intensive Individualized Smoking Cessation Program Delivered by Pharmacists
Status: COMPLETED
Conditions: Smoking Cessation|Smoking, Tobacco|Quality of Life
Interventions: BEHAVIORAL: Intensive Smoking Cessation Group|BEHAVIORAL: Abbreviated Smoking Cessation Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prostate Cancer With OligometaSTatic Relapse: Combining Stereotactic Ablative Radiotherapy and Durvalumab (MEDI4736)
Status: ACTIVE_NOT_RECRUITING
Conditions: Node; Prostate|Bone Metastases|Prostate Cancer Patients
Interventions: COMBINATION_PRODUCT: SBRT + Durvalumab|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Efficacy and Tolerability of Ketoprofen 40 mg Granules vs Placebo
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: OKITASK®|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Inhaled Montelukast (MK-0476) in Participants With Mild or Moderate Asthma (MK-0476-380 AM3)(COMPLETED)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Montelukast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of High-pressure Pulsatile Lavage Versus Manual Rinsing on Bone Cement Penetration in Total Knee Arthroplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee
Interventions: PROCEDURE: Bone lavage previous to cementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Development and Evaluation of Computerized Chemosensory Based Orbitofrontal Networks Training for Treatment of Pain
Status: COMPLETED
Conditions: Chronic Pain|Low Back Pain
Interventions: COMBINATION_PRODUCT: Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) short burst paradigm|COMBINATION_PRODUCT: Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) long burst paradigm|COMBINATION_PRODUCT: Computerized Chemosensory-Based Orbitofrontal Cortex Training plus beta caryophyllene (CBOT-Plus)|COMBINATION_PRODUCT: Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Opioid-based Versus Lidocaine-based Induction of Anesthesia With Propofol in Elderly
Status: RECRUITING
Conditions: Postinduction Hypotension|Elderly
Interventions: DRUG: fentanyl|DRUG: Lidocaine IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pegylated Interferon Alfa-2b Versus Interferon Alfa Therapy in Adult Essential Thrombocythemia
Status: RECRUITING
Conditions: Essential Thrombocytopenia
Interventions: DRUG: Recombinant Interferon Alpha|DRUG: Pegylated interferon alfa-2b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Larotaxel in Combination With Weekly Herceptin® in Patients With HER2 Positive Metastatic Breast Cancer
Status: COMPLETED
Conditions: Advanced Breast Cancer|Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: larotaxel (XRP9881)|DRUG: trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma
Status: RECRUITING
Conditions: Rhabdomyosarcoma
Interventions: DRUG: Irinotecan|DRUG: Actinomycin D|DRUG: Doxorubicin|DRUG: Ifosfamide|DRUG: Vincristine|DRUG: Vinorelbine|DRUG: Cyclophosphamide|DRUG: Temozolomide|RADIATION: radiotherapy|DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nurses' Negative Words and Postoperative Pain Management
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: BEHAVIORAL: No Words|BEHAVIORAL: Positive words|BEHAVIORAL: Partially Negative Words|BEHAVIORAL: Totally Negative Words
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Levalbuterol Versus Racemic Albuterol in Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Levalbuterol 1.25 mg|DRUG: Racemic Albuterol Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: High-intensity Interval Exercise and Chocolate Milk on Blood Glucose and Cognition
Status: COMPLETED
Conditions: Glycemic Response|Cognitive Function
Interventions: OTHER: Exercise and Chocolate Milk|OTHER: Exercise and Water|OTHER: Sitting and Chocolate Milk|OTHER: Sitting and Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Long-term Safety of Repeated QUTENZA Administration for Treatment of Pain Caused by Nerve Damage in Diabetic Patients
Status: COMPLETED
Conditions: Painful Diabetic Peripheral Neuropathy (PDPN)
Interventions: DRUG: QUTENZA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Boosting Exercise cApaCity With autOnomic Neuromodulation
Status: COMPLETED
Conditions: Aging|Inflammation|Cardiovascular Diseases
Interventions: DEVICE: Active Transauricular nerve stimulation|DEVICE: Sham transauricular nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetic Study of Oral MK-8527 QM in Participants at Low-Risk for HIV-1 Infection (MK-8527-007)
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV|HIV Pre-exposure Prophylaxis
Interventions: DRUG: MK-8527|DRUG: Placebo to MK-8527
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Dexmedetomidine-Ropivacine Versus Sufentanil-Ropivacaine for Epidural Labor Analgesia
Status: COMPLETED
Conditions: Pregnancy Related
Interventions: DRUG: Dexmedetomidine|DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Reducing Costs by Deprescribing Medications
Status: COMPLETED
Conditions: Polypharmacy|Deprescribing|Adverse Drug Reaction
Interventions: BEHAVIORAL: Deprescribing Intervention|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Open Label Study Exploring Tissue Histopathology After Ellacor® Procedure in an Abdominoplasty Model.
Status: COMPLETED
Conditions: Histopathology|Wrinkle|Rhytides
Interventions: DEVICE: ellacor® Micro-Coring procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Pilot Study to Investigate Plasma Bupivacaine Concentrations in Children Receiving Total Intravenous Anaesthesia and Caudal Analgesia
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: propofol|DRUG: sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Maintenance of Etomidate in General Anesthesia
Status: COMPLETED
Conditions: General Anesthesia
Interventions: DRUG: Etomidate|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs) (ALABASTER)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: methotrexate|DRUG: tocilizumab [RoActemra/Actemra]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pragmatic Feasibility Trial to Promote Student Perspective-Taking on Client Physical Activity: A Collaborative Project
Status: COMPLETED
Conditions: Communication
Interventions: BEHAVIORAL: Student practitioner perspective-taking intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase 3 Study Comparing the Effects of Intravenous Epoetin Hospira and Epoetin Alfa [Epogen] (Amgen) in Patients With Chronic Renal Failure Requiring Hemodialysis and Receiving Epoetin Maintenance Treatment. AiME - Anemia Management With Epoetin
Status: COMPLETED
Conditions: Chronic Kidney Disease|Chronic Renal Failure
Interventions: BIOLOGICAL: Epoetin Hospira|BIOLOGICAL: Epogen (Amgen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cough, Expiratory Training, and Chronic Aspiration After Head and Neck Radiotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer
Interventions: PROCEDURE: Barium Swallow|BEHAVIORAL: Questionnaires|DEVICE: Expiratory Muscle Strength Training (EMST) Device|DEVICE: Digital Manometer|BEHAVIORAL: Neurocognitive Exams|DRUG: Barium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Drug-drug Interaction Study of Ofatumumab With Bendamustine in Subjects With Indolent B-cell Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: ofatumumab|DRUG: bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Solriktug in Adult Participants With Asthma
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: Biological: Solrikitug Low Dose|DRUG: Biological: Solrikitug Mid Dose|DRUG: Biological: Solrikitug High Dose|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carboplatin, Vincristine, and Temozolomide in Treating Children With Progressive and/or Symptomatic Low-Grade Glioma
Status: COMPLETED
Conditions: Brain Tumor|Central Nervous System Tumor
Interventions: DRUG: carboplatin|DRUG: temozolomide|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotic Co-administration With Omega-3 Fatty Acids on NAFLD
Status: COMPLETED
Conditions: Type2 Diabetes|NAFLD|Probiotic|Omega-3 Fatty Acids
Interventions: DIETARY_SUPPLEMENT: Symbiter-Omega|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Clinical Performance of Two Frequent Replacement Silicone Hydrogel Multifocal Toric Contact Lenses
Status: COMPLETED
Conditions: Refractive Errors|Presbyopia|Astigmatism
Interventions: DEVICE: Lehfilcon A multifocal toric contact lenses|DEVICE: Samfilcon A multifocal toric contact lenses|DEVICE: CLEAR CARE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation and Patient Satisfaction of Shade Matching Between Natural Teeth and Monolithic All-ceramic Crowns Fabricated From Two Materials
Status: UNKNOWN
Conditions: Natural Optical Properties
Interventions: OTHER: Celtra Press
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Flexible or Fixed Dose LY2216684 as Adjunctive Treatment for Participants With Major Depressive Disorder Who Have Had a Partial Response to Selective Serotonin Reuptake Inhibitor (SSRI) Treatment
Status: COMPLETED
Conditions: Major Depressive Disorder (MDD)
Interventions: DRUG: LY2216684|DRUG: Placebo|DRUG: SSRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Retinitis Pigmentosa by Mesenchymal Stem Cells by Wharton's Jelly Derived Mesenchymal Stem Cells
Status: COMPLETED
Conditions: Retinitis Pigmentosa|Inherited Retinal Dystrophy
Interventions: BIOLOGICAL: Wharton's jelly derived mesenchymal stem cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Administration of Melatonin 5mg in the Prevention of Delirium in Older Adults Hospitalized in the Emergency Department
Status: UNKNOWN
Conditions: Delirium in Old Age
Interventions: DRUG: Melatonin 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections
Status: COMPLETED
Conditions: Fasciitis, Necrotizing|Severe Necrotizing Skin and Soft Tissue Infections|Fournier's Gangrene
Interventions: DRUG: Daptomycin 6mg/kg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of SHP465 in Adults Aged 18-55 Years With Attention-deficit/ Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: DRUG: SHP465 12.5mg capsules (one capsule daily)|OTHER: Placebo|DRUG: SHP465 12.5mg, 25mg, or 37.5mg capsules (one capsule daily)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Zoladex Plus Tamoxifen in Breast Cancer
Status: COMPLETED
Conditions: Mammography|Estrogen|Lipemia|Endometrium|Ultrasonography
Interventions: DRUG: tamoxifen|DRUG: Goserelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of USPIO-enhanced MRI for Detection of Lymph Node Metastases in Head and Neck Carcinoma
Status: UNKNOWN
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DIAGNOSTIC_TEST: USPIO-enhanced MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy Study of CPAP on Nitrate and Norepinephrine Levels in Severe and Mild-moderate Sleep Apnea (SABIO)
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Rectal & Sublingual Misoprostol Before Caesarian Section To Reduce Intra & Post-Operative Blood Loss
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Misoprostol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: 28 mm Ceramic-on-Ceramic Acetabular Cup Total Hip Replacement Study
Status: COMPLETED
Conditions: Joint Diseases
Interventions: DEVICE: 28 mm ceramic head on ceramic acetabular liner.|DEVICE: 28 mm ceramic head on polyethylene liner
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Hands and Hearts Together
Status: RECRUITING
Conditions: Parent-Child Relations|Development, Infant|Parenting|Development, Child
Interventions: BEHAVIORAL: Circle of Security Parenting|BEHAVIORAL: Little Talks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RSA RCT: Attune RP TKA Versus LCS RP TKA
Status: COMPLETED
Conditions: Osteoarthritis Arthritis|Joint Disease|Musculoskeletal Disease
Interventions: DEVICE: ATTUNE Knee Prosthesis by DePuy|DEVICE: LCS Knee Prosthesis by DePuy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating ABT-199 in Multiple Myeloma Subjects Who Are Receiving Bortezomib and Dexamethasone as Standard Therapy
Status: COMPLETED
Conditions: Relapsed/Refractory Multiple Myeloma
Interventions: DRUG: ABT-199|DRUG: bortezomib|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple-dose Nicotine Pharmacokinetics With a New Oral Nicotine Replacement Product.
Status: COMPLETED
Conditions: Tobacco Dependence
Interventions: DRUG: Oral Nicotine|DRUG: Nicotine Lozenge|DRUG: Nicotine gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Pharmacokinetic/Pharmacodynamic Drug-drug Interaction and Safety/Tolerability Between RLD2202 and RLD2203
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: RLD2202|DRUG: RLD2203
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Versus Late Placement
Status: RECRUITING
Conditions: Esthetics
Interventions: DEVICE: Implant placement (BLX implant system, Straumann, Basel, Switzerland)|PROCEDURE: Ridge preservation (Bio-Oss Collagen 250 mg, Geistlich Pharma AG, Wolhusen, Switserland)|PROCEDURE: Socket seal (Mucograft Seal, Geistlich Pharma AG, Wolhusen, Switserland)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Angiotensin 2 for Hepatorenal Syndrome
Status: WITHDRAWN
Conditions: Hepatorenal Syndrome|Cirrhosis|Kidney Failure, Acute
Interventions: DRUG: Angiotensin II|DRUG: Midodrine|DRUG: Octreotide|DRUG: Albumin solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The BEAUTIFUL Study: Effects of Ivabradine in Patients With Stable Coronary Artery Disease and Left Ventricular Systolic Dysfunction
Status: COMPLETED
Conditions: Coronary Disease|Ventricular Dysfunction, Left
Interventions: DRUG: Ivabradine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of BBI608 in Adult Patients With Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: BBI608|DRUG: Panitumumab|DRUG: Capecitabine|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Simeprevir in Combination With Sofosbuvir in Subjects With Chronic Genotype 4 Hepatitis C Virus Infection
Status: COMPLETED
Conditions: Chronic Hepatitis C|Genotype 4 Chronic Hepatitis C
Interventions: DRUG: Simeprevir|DRUG: Sofosbuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Treatment of Colon Cancer
Status: COMPLETED
Conditions: Colon Cancer
Interventions: DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Oxaliplatin|DRUG: Capecitabine|BIOLOGICAL: Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Silymarin for Non-Cirrhotic Patients With Non-Alcoholic Steatohepatitis
Status: COMPLETED
Conditions: Non-alcoholic Steatohepatitis
Interventions: OTHER: Placebo|DRUG: Silymarin 700 mg|DRUG: Silymarin 420 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Rosiglitazone/Metformin Therapy vs Rosiglitazone and Metformin in Type 2 Diabetes Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: rosiglitazone maleate/metformin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ibandronate (Bondronat) in Participants With Metastatic Bone Disease
Status: COMPLETED
Conditions: Pain; Bone Neoplasms; Neoplasm Metastasis
Interventions: DRUG: Ibandronate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Emicizumab for Severe Von Willebrand Disease (VWD) and VWD/Hemophilia A
Status: RECRUITING
Conditions: Von Willebrand Disease, Type 3|Concomitant VWD and Hemophilia
Interventions: DRUG: Emicizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Grass-SPIRE in Subjects With Grass Allergies and Asthma
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis|Asthma
Interventions: BIOLOGICAL: Grass-SPIRE|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Open-labeled, Multi-centric Trial in Subjects With Systolic Heart Failure to Evaluate Bisoprolol Treatment for the Effects on Surrogate Markers of Heart Failure in Korea
Status: COMPLETED
Conditions: Heart Failure, Congestive
Interventions: DRUG: Low Dose Bisoprolol|DRUG: High Dose Bisoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Pneumoperitoneum on Minimal Invasive Cardiac Output Measurements
Status: TERMINATED
Conditions: Pneumoperitoneum
Interventions: PROCEDURE: Pneumoperitoneum and SVV/PPV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Oral Isotretinoin for Cutaneous Photodamage
Status: UNKNOWN
Conditions: Photodamage|Photoaging
Interventions: DRUG: oral isotretinoin|DRUG: Tretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact Of Digital Photography & Conventional Method On The Accuracy Of Dental Shade Matching In The Esthetic Zone
Status: COMPLETED
Conditions: Accuracy of Dental Shade Selection in the Aesthetic Zone
Interventions: DEVICE: Digital photography using software Photoshop|DEVICE: Vita 3D master shade guide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: A Long-Term Safety and Efficacy Study of Lorecivivint in Subjects With Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Placebo|DRUG: Lorecivivint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Evaluation of Alirocumab (SAR236553/REGN727) in Patients With Primary Hypercholesterolemia on Stable Atorvastatin Therapy in Japan
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Alirocumab|DRUG: Placebo (for alirocumab)|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bronchial Ablation for Treatment of Asthma (BATA) Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Asthma
Interventions: DEVICE: SyMap Bronchial Ablation System|DEVICE: Boston Scientific Alair System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is Non-cycloplegic Photorefraction Applicable for Screening Refractive Risk Factors of Amblyopia?
Status: COMPLETED
Conditions: Amblyopia
Interventions: DEVICE: photorefraction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Rhythmic Gymnastics Training in Children With Down Syndrome
Status: COMPLETED
Conditions: Physical Conditioning, Human
Interventions: OTHER: swimming training|OTHER: rhythmic gymnastics training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Sirolimus and Vismodegib in Treating Patients With Solid Tumors or Pancreatic Cancer That is Metastatic or Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Acinar Cell Adenocarcinoma of the Pancreas|Duct Cell Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: vismodegib|DRUG: sirolimus|PROCEDURE: positron emission tomography|PROCEDURE: computed tomography|OTHER: pharmacological study|OTHER: laboratory biomarker analysis|RADIATION: fludeoxyglucose F 18
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label, Phase 1 Study in Healthy Adult Subjects to Examine the Effects of Multiple-Dose Ciprofloxacin on Ivacaftor and VX-661 in Combination With Ivacaftor
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: ivacaftor|DRUG: VX-661|DRUG: ciprofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In-Situ Therapeutic Cancer Vaccine for Metastatic Cancer Combining AlloStim With Tumor Cryoablation
Status: COMPLETED
Conditions: Metastatic Cancer
Interventions: BIOLOGICAL: AlloStim-7|PROCEDURE: percutaneous tumor cryoablation|BIOLOGICAL: AlloStim-7|BIOLOGICAL: AlloStim8 or AlloStim-9
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Triage - Symptoms and Other Predictors in an All-comer Emergency Department Population
Status: COMPLETED
Conditions: Triage Risk Stratification
Interventions: DIAGNOSTIC_TEST: Assessment of vital signs|DIAGNOSTIC_TEST: Assessment of patient mobility at presentation|DIAGNOSTIC_TEST: Assessment of level of consciousness by AVPUC scale|DIAGNOSTIC_TEST: Assessment of symptoms patients presenting when admitted to ED|DIAGNOSTIC_TEST: Assessment of what matters most in patients of 65 years and older|DIAGNOSTIC_TEST: Assessment of Decision-making in senior physicians|DIAGNOSTIC_TEST: Pain Numeric Rating Scale (NRS)|DIAGNOSTIC_TEST: Clinical Frailty Scale (CFS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Obesity Treatment to Improve Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Liraglutide / Semaglutide|DRUG: Dapagliflozin|DRUG: Liraglutide or Semaglutide / Dapagliflozin|DRUG: Liraglutide or Semaglutide / Dapagliflozin plus intensive weight loss nutrition|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BLI-800-301: BLI-800 vs an Active Control Bowel Preparation in Adult Subjects Undergoing Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: BLI-800|DRUG: Polyethylene glycol 3350 based bowel preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose:
Clinical trial: Safety and Efficacy of Bevacizumab in Combination With Carboplatin and Paclitaxel for Metastatic, Recurrent or Persistent Cervical Cancer
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: DRUG: Bevacizumab|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-Dispensing Evaluation of an Investigational Galyfilcon A Soft Contact Lens
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Galyfilcon A Habitual Lens|DEVICE: Galyfilcon A 8.7 BC (Investigational)|DEVICE: Galyfilcon A 8.3 BC (Investigational)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Late Subclinical Cardiovascular Disease in Testicular Cancer Survivors
Status: RECRUITING
Conditions: Testicular Cancer|Survivorship|ASCVD|Coronary Artery Disease|Lipid Disorder|Hypogonadism, Male|Cisplatin Adverse Reaction|Bone Marrow Transplant Complications
Interventions: DIAGNOSTIC_TEST: Lipid profile|DIAGNOSTIC_TEST: Coronary artery assessment|DIAGNOSTIC_TEST: Hormone levels for hypogonadism
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Temozolomide as Maintenance Therapy Following Induction Chemotherapy in Extensive Stage Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Extensive-stage Small Cell Lung Cancer
Interventions: DRUG: Temozolomide|DRUG: first-line chemotherapy|RADIATION: Prophylactic cranial irradiation|RADIATION: thoracic radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of BEBT-908 in the Relapsed or Refractory Diffuse Large B-cell Lymphoma Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed or Refractory Diffuse Large B-cell Lymphoma
Interventions: DRUG: BEBT-908 for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Cubicin With Vancomycin in Treatment of Participants With Complicated Skin and Skin Structure Infections in a Home Infusion Setting
Status: TERMINATED
Conditions: Complicated Skin or Skin Structure Infection
Interventions: DRUG: Daptomycin|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Autonomic Nerve Stimulation Using External Auditory Canal Electrodes
Status: COMPLETED
Conditions: Cardiac Arrhythmia|Cardiovascular Diseases
Interventions: OTHER: subthreshold low-level autonomic nerve stimulation using external auditory canal electrodes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Ba679BR Powder Inhalation in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium low|DRUG: Tiotropium high|DRUG: Placebo MDI|DRUG: Placebo inhalation capsule|DRUG: Oxitropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: PrEPARE-SCALE: Scaling up Integrated PrEP Delivery in Kenyan Maternal and Child Health Clinics
Status: NOT_YET_RECRUITING
Conditions: Hiv
Interventions: OTHER: Implementation strategy package
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Michigan Contraceptive Access, Research, and Evaluation Study: Phase 1
Status: ACTIVE_NOT_RECRUITING
Conditions: Pregnancy
Interventions: BEHAVIORAL: Gift card to be used for contraceptives that is valued at 50% of cost of name-brand IUD (August 26, 2018-March 3, 2019)|BEHAVIORAL: Gift card to be used for contraceptives that is valued at 100% of cost of name-brand IUD (March 4, 2019-March 31, 2023)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 100% Whey Protein Based Diet In Enhancing Pressure Ulcer Healing.
Status: TERMINATED
Conditions: Pressure Ulcer
Interventions: DIETARY_SUPPLEMENT: Peptamen®|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lapatinib/Carboplatin/Paclitaxel in Previously Treated Ovarian or Breast Cancer Patients
Status: COMPLETED
Conditions: Ovarian Epithelial Cancer Stage III|Stage IV Ovarian Cancer|Stage IV Breast Cancer
Interventions: DRUG: lapatinib (GW572016)|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Quality of Life for Colon Cancer Patients and Their Caregivers
Status: RECRUITING
Conditions: Colon Cancer
Interventions: BEHAVIORAL: Quality of Life Ted Talks|BEHAVIORAL: Quality of Life Supportive Resources
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Urgent Care Management of Respiratory Illness Enabled With Novel Testing Pathway
Status: COMPLETED
Conditions: Viral Infection|Acute Respiratory Infection|Upper Resp Tract Infection
Interventions: DIAGNOSTIC_TEST: BioFire® Respiratory Panel 2.1-EZ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Methylphenidate HCl or Modafinil in Treating Young Patients With Excessive Daytime Sleepiness After Cancer Therapy
Status: TERMINATED
Conditions: Central Nervous System Tumor, Pediatric|Fatigue|Specific Disorders of Sleep
Interventions: DRUG: methylphenidate hydrochloride|DRUG: modafinil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Preoperative Nutritional Support on Postoperative Outcome in Gastric Cancer Patients at Nutritional Risk by NRS-2002
Status: COMPLETED
Conditions: Malnutrition|Gastric Cancer
Interventions: DIETARY_SUPPLEMENT: carbohydrates|DIETARY_SUPPLEMENT: vitamins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of the Hepatitis B Virus (HBV) Vaccine, HEPLISAV Compared to Engerix-B Vaccine
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: HEPLISAV and/or Placebo|BIOLOGICAL: Engerix-B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Human Milk Lipid Profile Assessment and Influences of Mother's Diet
Status: UNKNOWN
Conditions: Breastfeeding|Human Milk|Diet Habit|Fatty Acid|Infant Growth
Interventions: OTHER: Dietary counseling and DHA dietary increase in breastfeeding mothers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER