pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Addiction Treatment in Russia: Oral vs. Naltrexone Implant
Status: COMPLETED
Conditions: Heroin Dependence|Opioid-Related Disorders
Interventions: DRUG: naltrexone implant|DRUG: oral naltrexone|DRUG: oral placebo naltrexone|DRUG: placebo implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of MK-3682B in Participants With Moderate to Severe Renal Insufficiency (MK-3682B-030)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: MK-3682B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Telitacicept in Subjects With Childhood-onset Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: Telitacicept 2.5 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel-HDFL for Locally Advanced and Recurrent/Metastatic Gastric Cancers
Status: COMPLETED
Conditions: Locally Advanced and Recurrent/Metastatic Gastric Cancer
Interventions: DRUG: Paclitaxel-HDFL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Standardized Nursing Intervention Protocol for HCT Patients
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Psychosocial Effects of Cancer and Its Treatment|Therapy-related Toxicity
Interventions: BEHAVIORAL: exercise intervention|BEHAVIORAL: telephone-based intervention|DIETARY_SUPPLEMENT: dietary intervention|OTHER: educational intervention|OTHER: questionnaire administration|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: assessment of therapy complications|PROCEDURE: peripheral blood stem cell transplantation|PROCEDURE: psychosocial assessment and care|PROCEDURE: quality-of-life assessment|PROCEDURE: standard follow-up care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Vitamin D Deficiency and Effect of Its Supplementation on Interstitial Lung Diseases(ILD).
Status: UNKNOWN
Conditions: Lung Diseases, Interstitial|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D3 (1.25 (OH)2 cholecalciferol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Gamma Delta T-cell Infusion for AML at High Risk of Relapse After Allo HCT
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Gamma Delta T-Cell Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Use of Apatinib Mesylate and Vinorelbine Versus Single Use of Vinorelbine in Triple-negative Breast Cancer
Status: UNKNOWN
Conditions: Triple-negative Breast Cancer
Interventions: DRUG: Vinorelbine + placebo|DRUG: Vinorelbine + Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Drug Levels, and Drug Effects of BMS-986308 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: BMS-986308|OTHER: Placebo (for BMS-986308)|DRUG: Furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Technique for Internal Jugular Central Venous Catheterization in Pediatric Cardiac Surgical Patients
Status: COMPLETED
Conditions: Accidental Puncture of Artery During Catheter Insertion
Interventions: DEVICE: Central Venous Catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Glutamine in Ischemic Heart Disease Patients Following Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: N(2)-L-Alanine L-Glutamine dipeptide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study Comparing LY2140023 to Atypical Antipsychotic Standard Treatment in Schizophrenic Patients
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: LY2140023|DRUG: aripiprazole|DRUG: olanzapine|DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Versus Late BCG Vaccination in HIV-1 Exposed Infants in Uganda in Uganda
Status: ACTIVE_NOT_RECRUITING
Conditions: Severe Illness|Septicaemia|Diarrhoea|Lower Respiratory Infection
Interventions: BIOLOGICAL: BCG at birth|BIOLOGICAL: Control arm: Delayed BCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Pharmacokinetic Study of RO4917523 in Healthy Japanese and Caucasian Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: RO4917523|DRUG: RO4917523|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Optimizing CO2 Injection Technique for EVAR
Status: UNKNOWN
Conditions: Abdominal Aortic Aneurysm|Endovascular Aortic Repair
Interventions: DEVICE: Technique 1|DEVICE: Technique 2|DEVICE: Technique 3|DEVICE: Technique 4
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase I Study of CD19-CAR-T2 Cells for Patients With Chemotherapy Resistant or Refractory CD19+ Acute Leukemia
Status: UNKNOWN
Conditions: Acute Leukemia
Interventions: BIOLOGICAL: CD19-CAR-T2 Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GPC3-directed CAR-T in the Treatment Amongst Subjects With Advanced Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: CAR-GPC3 T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stimulation to Improve Memory
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Dementia of Alzheimer Type
Interventions: DEVICE: 1 mA HD-tDCS|DEVICE: 2 mA HD-tDCS|DEVICE: 3 mA HD-tDCS|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of ALLO-501 Anti-CD19 Allogeneic CAR T Cells in Adults With Relapsed/Refractory Large B Cell or Follicular Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed/Refractory Large B Cell Lymphoma|Relapsed/Refractory Follicular Lymphoma
Interventions: GENETIC: ALLO-501|BIOLOGICAL: ALLO-647|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Dolasetron in Patients With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: Dolasetron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Blood Levels of Both Pegaspargase (S95014) Formulations (Liquid vs Lyophilized) in the Treatment of Paediatric Patients With Acute Lymphoblastic Leukemia (ALL)
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Lyophilized S95014|DRUG: Liquid S95014
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Diclofenac Gel in Women With Primary Dysmenorrhea
Status: ACTIVE_NOT_RECRUITING
Conditions: Dysmenorrhea Primary
Interventions: DRUG: Diclofenac 1%|DRUG: Diclofenac 3%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Bupivacaine Infiltration vs Continuous Perineural Ropivacaine Infusion for Post-operative Pain After Total Shoulder Arthroplasty
Status: TERMINATED
Conditions: Postoperative Pain|Shoulder Arthritis
Interventions: DRUG: Liposomal Bupivacaine Infiltration|DRUG: Continuous Perineural Ropivicaine Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Insulin Glargine Versus Biphasic Insulin Aspart 30/70 or Biphasic Insulin Aspart 30/70 in Combination With Metformin in Subjects With Type 2 Diabetes.
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart|DRUG: insulin glargine|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tralement Versus a Fixed-dose Trace Element Combination Product of Zinc, Copper, and Selenious Acid to Evaluate Product Safety in Pediatric Patients >3 to 17 Years of Age Requiring Long-term Parenteral Nutrition
Status: NOT_YET_RECRUITING
Conditions: Manganese Safety in Pediatric Patients
Interventions: DRUG: Tralement|DRUG: Fixed-dose trace element combination product of zinc, copper, and selenious acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coupons for Safe Water Project
Status: RECRUITING
Conditions: Death|Death, Infant|Diarrhea|Diarrhea, Infantile|Water-Borne Infectious Disease|Water-Related Diseases
Interventions: OTHER: Coupons for safe water program: Treatment|OTHER: Coupons for safe water program: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Tumescent Anesthesia Antibiotic Delivery (TAAD)
Status: UNKNOWN
Conditions: Surgical Site Infection|Thrombosis|Sepsis
Interventions: DRUG: Tumescent Anesthesia and antibiotic delivery (TAAD) plus IVAD|DEVICE: SubQKath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Carotid Implants for PreveNtion of STrokE ReCurrEnce From Large Vessel Occlusion in Atrial Fibrillation Patients Treated With Oral Anticoagulation
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation|Oral Anticoagulation|Stroke|Implant
Interventions: DEVICE: Vine Filter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Antimicrobial PK in Infants With Suspected or Confirmed Infection
Status: COMPLETED
Conditions: Infection
Interventions: DRUG: Ampicillin|DRUG: Metronidazole|DRUG: Piperacillin/Tazobactam|DRUG: Acyclovir|DRUG: Amphotericin B|DRUG: Ambisome|DRUG: Anidulafungin|DRUG: Caspofungin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Safety, Pharmacokinetics, and Pharmacodynamics of CNTO 3649 in Healthy Adults and Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: CNTO 3649 IV (Healthy participants)|DRUG: CNTO 3649 SC (Healthy participants)|DRUG: CNTO 3649 SC (Diabetic patients)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Platelet Derived Growth Factor Stimulates Bone Fill and Rate of Attachment Level Gain
Status: COMPLETED
Conditions: Periodontitis
Interventions: BIOLOGICAL: B-TCP + 0.3 mg/ml rhPDGF-BB in buffer|BIOLOGICAL: B-TCP + 1.0 mg/ml rhPDGF-BB in buffer|BIOLOGICAL: B-TCP +buffer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Glucocortioids in Human Skeletal Muscle, Adipose Tissue and Skin
Status: NOT_YET_RECRUITING
Conditions: Glucocorticoids Toxicity|Iatrogenic Effect
Interventions: OTHER: Prednisolone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Two Glatiramer Acetate (GA) Formulations in Relapsing-Remitting Multiple Sclerosis (RRMS) Patients
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Glatiramer Acetate 20 mg/0.5 mL|DRUG: Glatiramer acetate 20 mg/0.5 mL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Diaphragmatic Breathing Exercise for Patients Undergoing Arthrodesis Surgery for Adolescent Idiopathic Scoliosis.
Status: COMPLETED
Conditions: Adolescent Idiopathic Scoliosis|Spinal Fusion|Pain Management|Exercise
Interventions: PROCEDURE: STANDARD PHYSIOTHERAPY TREATMENT|PROCEDURE: EXPERIMENTAL diaphragmatic breathing exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Iron Absorption From Fortified Extruded Rice Using Different Extruding Temperatures.
Status: UNKNOWN
Conditions: Iron-deficiency
Interventions: DIETARY_SUPPLEMENT: Reference meal|DIETARY_SUPPLEMENT: Test meal A|DIETARY_SUPPLEMENT: Test meal B|DIETARY_SUPPLEMENT: Test meal C|DIETARY_SUPPLEMENT: Test meal D|DIETARY_SUPPLEMENT: Test meal E|DIETARY_SUPPLEMENT: Test meal F
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Pharmacokinetics (PK) of Methylnaltrexone (MNTX) in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Adult Subjects
Interventions: DRUG: Methylnaltrexone bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Combination Regimen Grazoprevir (MK-5172) and Elbasvir (MK-8742) ± Ribavirin in Participants With Chronic Hepatitis C (MK-5172-035)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Grazoprevir|DRUG: Elbasvir|DRUG: Placebo to Elbasvir|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Filgrastim (G-CSF) Plus ABVD in the Treatment of HIV-Associated Hodgkin's Disease
Status: COMPLETED
Conditions: HIV Infections|Hodgkin's Disease
Interventions: DRUG: Vinblastine sulfate|DRUG: Dacarbazine|DRUG: Filgrastim|DRUG: Bleomycin sulfate|DRUG: Doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Topical Minocycline FXFM244 in Impetigo Patients
Status: COMPLETED
Conditions: Impetigo
Interventions: DRUG: Topical Minocycline Foam FXFM244
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PK of CHF6001 in Subjects With Mild, Moderate and Severe Renal Impairment vs. Healthy Volunteers
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: CH6001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Combination Chemotherapy and Nelarabine in Treating Patients With T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma
Status: RECRUITING
Conditions: T Acute Lymphoblastic Leukemia|T Lymphoblastic Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Dexamethasone|DRUG: Doxorubicin Hydrochloride|DRUG: Mercaptopurine|DRUG: Methotrexate|DRUG: Nelarabine|DRUG: Pegaspargase|DRUG: Prednisone|DRUG: Venetoclax|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Platinum Based Chemotherapy Plus Indomethacin
Status: COMPLETED
Conditions: Colorectal Neoplasms|Esophageal Neoplasms|Ovarian Neoplasms
Interventions: DRUG: Indomethacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of the EndyMed Pro System Using RF Micro-needles Fractional Skin Remodeling
Status: UNKNOWN
Conditions: Aging
Interventions: DEVICE: EndyMed Pro™ RF Micro-Needles
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Exercise on Eyeblink Conditioning in Spinocerebellar Ataxias
Status: NOT_YET_RECRUITING
Conditions: Spinocerebellar Ataxias
Interventions: BEHAVIORAL: Aerobic Training|BEHAVIORAL: Balance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-dose Methotrexate for Change in Global Initiative for Asthma Step 5 Medications in Chronic Severe Asthma
Status: UNKNOWN
Conditions: Low Dose Methotrexate in Severe Chronic Asthma
Interventions: DRUG: Methotrexate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Dietary Strategies for Remission of Type 2 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Overweight and Obesity|Hypertension|Glucose Intolerance|Insulin Resistance|Dyslipidemia Associated With Type II Diabetes Mellitus
Interventions: OTHER: Energy restricted diet|OTHER: Low carbohydrate high fat diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Treatment of Iron Deficiency and Iron Deficiency Anemia With an Antioxidant, Vitamin E
Status: COMPLETED
Conditions: Iron Deficiency|Iron Deficiency Anemia
Interventions: DRUG: Vitamin E|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of NCO-48 Fumarate in Healthy Subjects
Status: COMPLETED
Conditions: Hepatitis B
Interventions: DRUG: NCO-48 Fumarate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab Versus Cyclophosphamide in Connective Tissue Disease-ILD
Status: COMPLETED
Conditions: Interstitial Lung Disease|Scleroderma|Idiopathic Inflammatory Myositis|Mixed Connective Tissue Disease
Interventions: DRUG: Rituximab|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of CSL's 2009 H1N1 Influenza Vaccine (CSL425) in Healthy Adults in the USA
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: CSL425|BIOLOGICAL: CSL425|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Peri-operative tEstosterone Levels on oNcological and Functional Outcomes in RadiCal prostatEctomy
Status: RECRUITING
Conditions: Prostatic Neoplasms|Hypogonadism|Testosterone Deficiency
Interventions: DRUG: Testosterone gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: BNP, Serum Troponin and D-dimer as Risk Factors in Patients With COVID-19
Status: UNKNOWN
Conditions: COVID-19
Interventions: DIAGNOSTIC_TEST: N terminal pro B type natriuretic peptide (NTproBNP), D-Dimer, and serum Tropinin - I
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Ganetespib (STA-9090) + Docetaxel in Advanced Non Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer Stage IIIB|Non-small Cell Lung Cancer Stage IV|Non-small Cell Lung Cancer Metastatic
Interventions: DRUG: Docetaxel|DRUG: Combination of ganetespib and docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aerobic Training Effect on the Improvement of Pain Perception in Patients With Fibromyalgia and Migraine
Status: UNKNOWN
Conditions: Migraine|Fibromyalgia
Interventions: OTHER: Aerobic training|OTHER: Control Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endometriosis and Microvascular Dysfunction; Simvastatin and Duavee
Status: RECRUITING
Conditions: Endometriosis
Interventions: DRUG: simvastatin 10mg|DRUG: Bazedoxifene 20/Estrogens,Con 0.45Mg Tb
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Ruxo-BEAT Trial in Patients With High-risk Polycythemia Vera or High-risk Essential Thrombocythemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Polycythemia Vera (PV)|Essential Thrombocythemia (ET)
Interventions: DRUG: Ruxolitinib|DRUG: BAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemotherapy Plus Toripalimab in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ASSURE Study - Arrhythmia Single Shock DFT Versus ULV: Risk Reduction Evaluation With ICD Implantations
Status: COMPLETED
Conditions: Tachyarrhythmia
Interventions: DEVICE: ICD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Cooling Sensation Flavor on the Swallow Response in Post-stroke Patients With Oropharyngeal Dysphagia
Status: RECRUITING
Conditions: Oropharyngeal Dysphagia|Stroke|Swallowing Disorder
Interventions: DIETARY_SUPPLEMENT: Pre-thickened oral nutritional supplement with a cooling sensation flavour|DIETARY_SUPPLEMENT: Pre-thickened oral nutritional supplement without a cooling sensation flavour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Elevated Heart Rate in Patients With Severe Sepsis by Ivabradine
Status: UNKNOWN
Conditions: Sepsis, Severe
Interventions: DRUG: Ivabradine Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ABT-888 and Gemcitabine Hydrochloride in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Adult Solid Neoplasm|BRCA1 Mutation Carrier|BRCA2 Mutation Carrier
Interventions: OTHER: Diagnostic Laboratory Biomarker Analysis|DRUG: Gemcitabine Hydrochloride|OTHER: Pharmacological Study|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D With Omega-3 or Metformin in Osteoarthritis
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: Omega-3|DRUG: Metformin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Bimatoprost to Treat Hypotrichosis of the Eyelashes After Application to the Eyelid Margin
Status: COMPLETED
Conditions: Hypotrichosis
Interventions: DRUG: Bimatoprost 0.03% solution|DRUG: Vehicle solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy And Safety Of Xeliri + Avastin Followed By Xelox + Avastin Or Reverse Sequence In Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Capecitabine|DRUG: Capecitabine|DRUG: Bevacizumab|DRUG: Oxaliplatin|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TAS2940 in Participants With Locally Advanced or Metastatic Solid Tumor Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor|Glioblastoma|Non-small Cell Lung Cancer|Breast Cancer
Interventions: DRUG: TAS2940|DRUG: TAS2940
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myocardial Fibrosis in Patients With Permanent Pacemakers
Status: ACTIVE_NOT_RECRUITING
Conditions: Fibrosis|Atrial Fibrillation|Atrial Flutter
Interventions: DEVICE: pacemakers implantation and assessment of cardiac function and cardiac fibrosis|DIAGNOSTIC_TEST: assessment of cardiac function and cardiac fibrosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Benfotiamine Effect on Advanced Glycation End Products(AGEs) and Soluble Receptor for AGEs(sRAGE) in Diabetes Mellitus.
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Benfotiamine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetic Interaction and Safety/Tolerability Between NVP-1805-R1 and NVP-1805-R2
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: NVP-1805-R1|DRUG: NVP-1805-R2|DRUG: NVP-1805-R1 and NVP-1805-R2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expert vs. Non-expert Abdominal Electromyographic Control in Vojta Therapy
Status: NOT_YET_RECRUITING
Conditions: Abdominal Muscles
Interventions: OTHER: Vojta Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Bevacizumab (Avastin®) in Combination With Temozolomide and Radiotherapy in Participants With Newly Diagnosed Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: Bevacizumab|DRUG: Temozolomide|RADIATION: Radiation therapy|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Previously Untreated Patients With Malignant Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma|Neoplasm Metastasis
Interventions: DRUG: CP-4055 (ELACYT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two-Fraction Ultrahypofractionated Radiotherapy With Focal Boost for Intermediate Risk, Localized Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer|Prostate Adenocarcinoma|Localized Prostate Carcinoma
Interventions: RADIATION: Ultrahypofractionated MRgRT in 2 fractions|RADIATION: Standard of care: MRgRT in 5 fractions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study Design of a Mobile Health (mHealth) Technology Associated Improvement of Drug Adherence in Patients With Acute Myocardial Infarction and Protocol for the Randomized, Controlled Trial（RESCIND-3)
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: BEHAVIORAL: Usual Text Messages|BEHAVIORAL: Personalized reminders|BEHAVIORAL: Internet-based counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: 1% Topical Pimecrolimus Cream for the Treatment of the Rash Associated With ERBITUX
Status: TERMINATED
Conditions: Rash
Interventions: DRUG: Pimecrolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Personalized Oncology Promoting Equity for Black Lives
Status: RECRUITING
Conditions: Hereditary Cancer|Genetic Testing
Interventions: BEHAVIORAL: Relational agent (RA) / Chatbot|BEHAVIORAL: Enhanced Usual Care (EUC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Tolerability Study of Trichostatin A In Subjects With Relapsed or Refractory Hematologic Malignancies
Status: UNKNOWN
Conditions: Relapsed or Refractory Hematologic Malignancies
Interventions: DRUG: Trichostatin A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigator-initiated Phase I Exploratory Clinical Study of the Safety, Tolerability, and Efficacy of BST02 Injection in the Treatment of Locally Advanced/Metastatic Liver Cancer
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced/Metastatic Liver Cancer
Interventions: BIOLOGICAL: BST02 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Response-Based Therapy Assessed By PET Scan in Treating Patients With Bulky Stage I and Stage II Classical Hodgkin Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: ABVD|DRUG: BEACOPP|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on Cerebello-Spinal tPCS in Ataxia
Status: UNKNOWN
Conditions: Cerebellar Ataxia
Interventions: DEVICE: Active Transcranial pulsed current stimulation (tPCS)|DEVICE: Sham Transcranial pulsed current stimulation (tPCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant TACE to Reduce the HCC Recurrence After Resection
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: PROCEDURE: Adjuvant TACE|PROCEDURE: Follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VRC-HIVMAB060-00-AB (VRC01) in People With Chronic HIV Infection Undergoing Analytical Treatment Interruption
Status: COMPLETED
Conditions: HIV
Interventions: BIOLOGICAL: VRC-HIVMAB060-00-AB (VRC01)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peripheral Blood Stem Cell Transplantation Using the CliniMACS Device
Status: COMPLETED
Conditions: Malignant Diseases (ie, Leukemia, MDS, Lymphoma)|Non-malignant Diseases (ie, Bone Marrow Failure Syndromes)
Interventions: DEVICE: CliniMACS (CD+3, CD+19 depletion)|DEVICE: CliniMACS (CD 34+ positive selection)|OTHER: HSCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Stroke, Premature Death and Cognitive Decline in a Broader Community of Patients With Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: Direct Oral Anticoagulants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Pilot Study of the Effects of BCG Immunization on CSF and Blood-based Biomarkers in Older Adults.
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Bacillus Calmette-Guerin (BCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Randomized Controlled Phase II Trial of Pre-operative Celecoxib Treatment in Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms|Breast Cancer
Interventions: DRUG: celecoxib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Continued Versus Discontinued Oxytocin Stimulation of Labour
Status: COMPLETED
Conditions: Adverse Reaction to Oxytocin
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Exogenous Ketone Supplementation and Cognitive Function During Exercise
Status: UNKNOWN
Conditions: Ketonemia|Mental Fatigue|Ketosis
Interventions: BEHAVIORAL: mental fatiguing task|BEHAVIORAL: 45 - minute simulated soccer game|BEHAVIORAL: cognitive function
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Disease Management in Asthma or Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)|Asthma
Interventions: OTHER: Pulmonary disease management|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study of a 4-Dose Series in Healthy Infants
Status: COMPLETED
Conditions: Pneumococcal Disease
Interventions: BIOLOGICAL: 20-valent pneumococcal conjugate vaccine|BIOLOGICAL: 13-valent pneumococcal conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ketamine Infusion for Social Anxiety Disorder
Status: COMPLETED
Conditions: Social Anxiety Disorder
Interventions: DRUG: Ketamine|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 52-Week Study of Ritlecitinib Oral Capsules in Adults and Adolescents With Nonsegmental Vitiligo (Active and Stable) Tranquillo
Status: RECRUITING
Conditions: Stable Nonsegmental Vitiligo|Active Nonsegmental Vitiligo
Interventions: DRUG: Ritlecitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing Youth Violence Through Building Equitable Communities
Status: ENROLLING_BY_INVITATION
Conditions: Suicide|Violence in Adolescence
Interventions: BEHAVIORAL: Culturally Responsive Practices (CRP)|BEHAVIORAL: Culturally-Responsive Schoolwide Positive Behavior Interventions and Supports (C-SWPBS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Allo-HSCT on Bone Remodeling: Evolution of Bone Mineral Density and Architecture Measured by Bone Densitometry
Status: NOT_YET_RECRUITING
Conditions: Myeloid Leukemia, Acute
Interventions: OTHER: Bone osteodensitometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: ATS 3f(r) Aortic Bioprosthesis Model 1000, 19mm
Status: TERMINATED
Conditions: Heart Valve Diseases
Interventions: DEVICE: ATS 3f® Aortic Bioprosthesis, Model 1000, 19mm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-sampling and Human Papillomavirus (HPV)-Testing for Unscreened Women in Cervical Cancer Prevention
Status: COMPLETED
Conditions: Uterine Cervical Neoplasms|Uterine Cervical Dysplasia
Interventions: OTHER: Screening test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Older Adult Effectiveness of 2 Treatments
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Caries
Interventions: DEVICE: A "simple medical strategy" consisting of silver diamine fluoride (SDF)|DEVICE: B "typical dental strategy" consisting of atraumatic restorative treatment (ART) with glass ionomer cement + Fluoride varnish (FV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treg Therapy in Subclinical Inflammation in Kidney Transplantation
Status: COMPLETED
Conditions: Kidney Transplant|Adult Living Donor Kidney Transplant Recipients|Renal Transplant|Living Kidney Donor
Interventions: BIOLOGICAL: Polyclonal Regulatory T Cells|DRUG: Everolimus|DRUG: Tacrolimus|DRUG: Mycophenolate mofetil|DRUG: Mycophenolic acid|DRUG: Acetaminophen|DRUG: Diphenhydramine|PROCEDURE: Biopsy, Kidney|PROCEDURE: Blood Draw|PROCEDURE: Leukapheresis|PROCEDURE: IS regimen conversion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Face Masks and Oxygen Levels - What Happens During Exercise? (Masks in Exercise - a RandomIsed Trial)
Status: COMPLETED
Conditions: Impact of Masks on Oxygen Levels
Interventions: DEVICE: cloth mask|DEVICE: surgical mask|DEVICE: FFP2 respirator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: To Explore the Efficacy and Safety of Surgical Treatment for Constipation, as Well as the Changes of Postoperative Intestinal Motility, Flora, Nutritional Status and Other Indicators
Status: COMPLETED
Conditions: Constipation|Surgical Treatment
Interventions: PROCEDURE: Subtotal colectomy was performed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AIM1: Adequate Selection of Patients for Thyroid Biopsy: Evaluation of a Shared Decision Making Conversation Aid
Status: COMPLETED
Conditions: Thyroid Nodules|Thyroid Cancer
Interventions: BEHAVIORAL: Counseling using the electronic conversation aid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Protocol for a Diagnostic Test Accuracy of Histological Muscle and Skin Biopsies of Rheumatoid Arthritis Patients Revealing Objective Chronic Widespread Pain Phenomena Related to Fibromyalgia
Status: RECRUITING
Conditions: Rheumatoid Arthritis|Fibromyalgia, Secondary|Widespread Chronic Pain|Muscle Disorder
Interventions: DIAGNOSTIC_TEST: Muscle- and skin biopsies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Botulism Outbreak in Thailand (Episode II)
Status: COMPLETED
Conditions: Botulism
Interventions: DRUG: Botulinum AntiToxin|PROCEDURE: neuro-electrophysiologic study, repetitive nerve stimulation|PROCEDURE: : Protocol early weaning ventilator after recovery of repetitive nerve stimulation and stable negative inspiratory pressure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment Schistosomal Portal Hypertension: Efficacy of Endoscopy or Surgery
Status: COMPLETED
Conditions: Schistosomiasis Mansoni|Portal Hypertension|Upper Gastrointestinal Bleeding
Interventions: PROCEDURE: Endoscopic treatment|PROCEDURE: Total EGDS+ endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ultrasound Versus Palpation for Epidural Catheterization
Status: COMPLETED
Conditions: Epidural Anesthesia|Spinal Ultrasound
Interventions: PROCEDURE: Double-space combined spinal-epidural anesthesia|RADIATION: Preprocedure spinal ultrasound|RADIATION: Sham ultrasound procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Tolerability of Fezolinetant in Women Seeking Treatment for Relief of Vasomotor Symptoms (VMS) Associated With Menopause
Status: COMPLETED
Conditions: Hot Flashes
Interventions: DRUG: Fezolinetant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Endotracheal Intubation Using Glidescope Video-Laryngoscope
Status: COMPLETED
Conditions: Respiratory Failure
Interventions: PROCEDURE: Direct laryngoscopy|DEVICE: Video laryngoscopy (Glidescope)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measuring the Feasibility and the Effects of Chair Massage on Pain and Discomfort in the Cardiac Sonographer
Status: COMPLETED
Conditions: Overuse Injury|Repetitive Strain Injury
Interventions: PROCEDURE: Massages ± Stretches
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Health Costs and Resource Utilization
Status: TERMINATED
Conditions: Ulcerative Colitis|Crohn's Disease
Interventions: OTHER: Measurement of drug (Adalimumab/Infliximab)|OTHER: Intensify treatment with the existing drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (Droxi-304)
Status: COMPLETED
Conditions: Primary Autonomic Failure|Dopamine Beta Hydroxylase Deficiency|Non-Diabetic Neuropathy|Neurogenic Orthostatic Hypotension
Interventions: DRUG: Droxidopa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Crossover Study to Test the Impact of Using a Software for Smartphones and Tablets in Treating Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes|Quality of Life|Hypoglycaemia
Interventions: DEVICE: Webdia Software
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Checkpoint Therapy With Nivolumab Esophageal Squamous Cell Carcinoma
Status: TERMINATED
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Nivolimumab+Carboplatin/paclitaxel+Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protocol for the Clinical Evaluation of Lyophilized Amniotic Fluid in the Treatment of Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Amniotic Fluid|OTHER: Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Bone Preservation After Molar Extraction Using Photobiomodulation Combined With Biomaterial Grafting
Status: RECRUITING
Conditions: Extracting Own Teeth|Bone Substitutes
Interventions: PROCEDURE: Extraction|RADIATION: low level laser therapy|BIOLOGICAL: Plenum® OSShp and Plenum® Guide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of Pegylated Inferferon Alfa-2b (PEG-Intron™) Versus Pegylated Interferon Alfa-2a (PEGASYS™) in Participants With Chronic Hepatitis B (P08450)
Status: TERMINATED
Conditions: Hepatitis B, Chronic
Interventions: BIOLOGICAL: PEG-Intron™|BIOLOGICAL: PEGASYS™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Immunomodulator as an Adjunct Therapy in Pulmonary Tuberculosis (TB) Retreatment Patients
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: Intra-dermal administration of Mycobacterium w
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Walking Intervention for Neuropathic Pain in Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries|Neuropathic Pain
Interventions: OTHER: VR Game 1|OTHER: VR Game 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT