pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Multi-professional Team Intervention on Physical Activity Referrals in Primary Care Patients With Cardiovascular Risk Factors-the Dalby Lifestyle Intervention Cohort (DALICO) Study
Status: WITHDRAWN
Conditions: Motivation for Physical Activity
Interventions: BEHAVIORAL: Multi-professional team intervention with PAR, lifestyle brochure|BEHAVIORAL: Ordinary recommendations on health behaviours, lifestyle brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial of Autologous Bone Marrow Derived Stem Cells in Paediatric Heart Failure
Status: COMPLETED
Conditions: Dilated Cardiomyopathy
Interventions: BIOLOGICAL: stem cell injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude
Status: COMPLETED
Conditions: Intermittent Hypoxia
Interventions: OTHER: Melatonin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Synergy Disc for the Treatment of 2 Level Cervical Degenerative Disc Disease Compared With Cervical Fusion Surgery
Status: RECRUITING
Conditions: Cervical Degenerative Disc Disease
Interventions: DEVICE: Anterior Cervical Discectomy and Fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Zonisamide to Prevent Olanzapine-Associated Weight Gain
Status: COMPLETED
Conditions: Weight Gain
Interventions: DRUG: zonisamide|DRUG: olanzapine|DRUG: Zonisamide|DRUG: Sugar Pill (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Azithromycin to Prevent Recurrent Trichiasis Following Surgery in Ethiopia
Status: COMPLETED
Conditions: Trichiasis
Interventions: DRUG: azithromycin|DRUG: topical tetracycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tolerability and Pharmacokinetics of a Single 900 mg Oral Dose of BIA 2-093 and Oxcarbazepine in Healthy Volunteers
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: BIA 2-093|DRUG: Oxcarbazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Tetrathiomolybdate in Patients With Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Tetrathiomolybdate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Vagus Nerve Stimulation (VNS) for Neuromotor Adaptations
Status: COMPLETED
Conditions: Healthy Young Adults
Interventions: OTHER: tVNS|OTHER: Motor training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mobile Health Intervention for Active Tuberculosis
Status: COMPLETED
Conditions: Tuberculosis|Adherence, Medication
Interventions: BEHAVIORAL: Mobile phone TB treatment support app plus usual care|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bioequivalence of Dotilavir Sodium Tablets in Healthy Subjects in the Fasting and Fed State
Status: UNKNOWN
Conditions: Healthy Volunteers
Interventions: DRUG: Dotilavir sodium tablet|DRUG: Dotilavir sodium tablet(Tivicay@)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: CD123/CLL1 CAR-T Cells for R/R AML (STPHI_0001)
Status: UNKNOWN
Conditions: Relapsed/Refractory AML
Interventions: BIOLOGICAL: CD123/CLL1 CAR-T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The eMESH 1 Feasibility Study
Status: UNKNOWN
Conditions: Atherosclerosis of Autologous Vein Coronary Artery Bypass Graft(s)
Interventions: DEVICE: eSVS Mesh treated saphenous vein graft|OTHER: Control saphenous vein graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Vibrating Capsule in Patients With Chronic Constipation
Status: UNKNOWN
Conditions: Chronic Constipation
Interventions: DEVICE: Vibrating Capsule|DEVICE: Sham Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clofarabine, Etoposide, and Mitoxantrone for Relapsed and Refractory Acute Leukemias
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: Clofarabine|DRUG: Mitoxantrone|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin A Adult Gastrocnemius Muscle Study
Status: COMPLETED
Conditions: Muscle Spasticity|Stroke
Interventions: DRUG: BOTOX-A®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Ultrasound-guided Rendezvous Versus Precut Papillotomy
Status: RECRUITING
Conditions: Bile Duct Diseases
Interventions: PROCEDURE: EUS-guided rendezvous|PROCEDURE: Early precut papillotomy group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Gene Therapy Study of BMN 331 in Subjects With Hereditary Angioedema
Status: ACTIVE_NOT_RECRUITING
Conditions: Hereditary Angioedema|HAE
Interventions: GENETIC: Dose 1 of BMN 331|GENETIC: Dose 2 of BMN 331|GENETIC: Dose 3 of BMN 331|GENETIC: Dose 4 of BMN 331|GENETIC: Dose 5 of BMN 331|GENETIC: Dose 6 of BMN 331|GENETIC: Dose 7 of BMN 331
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrical Activity of the Diaphragm and Respiratory Mechanics During NAVA
Status: RECRUITING
Conditions: Work of Breathing|Lung Transplantation|Neurally Adjusted Ventilatory Assist|Ventilator-Induced Lung Injury
Interventions: DEVICE: NAVA GROUP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-dose Protocol for Computed Tomography-guided Lung Biopsy
Status: COMPLETED
Conditions: Lung Cancer, Adenocarcinoma|Lung Inflammatory Pseudotumor
Interventions: RADIATION: Low-dose protocol computed tomography|RADIATION: Standard-dose protocol computed tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Erdafitinib in Participants With Advanced Solid Tumors and Fibroblast Growth Factor Receptor (FGFR) Gene Alterations
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: Erdafitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mirabegron in Parkinson Disease and Impaired Cognition
Status: COMPLETED
Conditions: Parkinson Disease|Overactive Bladder|Impaired Cognition
Interventions: DRUG: mirabegron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Patient Outcomes From the Kidney Allograft Outcomes AlloSure Registry
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Transplant Rejection
Interventions: DIAGNOSTIC_TEST: Donor-derived cell-free DNA (AlloSure®)|OTHER: Standard care|DIAGNOSTIC_TEST: Peripheral blood gene expression profiling (AlloMap Kidney)|DIAGNOSTIC_TEST: Analytic platform (IBox)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Long-term Investigation of Resveratrol on Fat Metabolism in Obese Men With Nonalcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Obesity|Nonalcoholic Fatty Liver Disease
Interventions: DIETARY_SUPPLEMENT: Resveratrol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of N-acetyl Cystein (NAC) Supplementation in G6PD Deficient Individuals After Acute Exercise
Status: UNKNOWN
Conditions: G6PD Deficiency
Interventions: DRUG: N-acetyl cystein|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylaxis of Ventilator Associated Pneumonia by Continuous Lateral Rotation Therapy
Status: COMPLETED
Conditions: Pneumonia, Ventilator-Associated
Interventions: PROCEDURE: Continuous lateral rotation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Pivotal Study of the Premia Spine TOPS™ System
Status: COMPLETED
Conditions: Lumbar Spinal Stenosis|Degenerative Spondylolisthesis
Interventions: DEVICE: Total Posterior Spine System (TOPS)|PROCEDURE: Transforaminal Lumbar Interbody Fusion (TLIF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Different Anti-Thrombotic Strategies on the Incidence of Silent Cerebral Embolism After Percutaneous Left Atrial Appendage Occlusion
Status: RECRUITING
Conditions: Atrial Fibrillation|Left Atrial Appendage Occlusion|Silent Cerebral Embolism
Interventions: DRUG: aspirin and clopidogrel|DRUG: Rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MRI-Based Preoperative Accelerated Partial Breast Irradiation
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: RADIATION: Phase II - Preoperative Radiation followed by Lumpectomy.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online 1-Day CBT-Based Workshops for Preventing Postpartum Depression
Status: RECRUITING
Conditions: Postpartum Depression|Postpartum Anxiety
Interventions: BEHAVIORAL: Online 1-Day Cognitive Behavioural Therapy-Based Workshop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Preoperative Dose of Co-amoxiclav for Prevention of Postoperative Complications in Dentoalveolar Surgery
Status: UNKNOWN
Conditions: Infection
Interventions: DRUG: Co-Amoxiclav|DRUG: Paracetamol|DRUG: Chlorhexidine mouthwash|DRUG: Normal saline|DRUG: Amoxicillin 500 Mg|DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: OnabotulinumtoxinA Treatment in Adult Patients With Upper Limb Spasticity
Status: TERMINATED
Conditions: Muscle Spasticity|Stroke
Interventions: BIOLOGICAL: onabotulinumtoxinA|DRUG: placebo (normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Assess the Adverse Effects and Change in Condition of OnabotulinumtoxinA X Injection in Adult Participants With Forehead Lines
Status: COMPLETED
Conditions: Forehead Lines
Interventions: DRUG: OnabotulinumtoxinA X|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postprandial Response to Almond Consumption in Overweight Hispanic Pregnant Women
Status: COMPLETED
Conditions: Diabetes, Gestational
Interventions: OTHER: Bagel|OTHER: Cream Cheese|OTHER: Almond Butter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Veterans Integrated Service Network (VISN) 23 Lung Disease Self Management/Case Management Program
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: case management|BEHAVIORAL: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Acute Hepatitis C Virus in HIV Co-Infection
Status: COMPLETED
Conditions: Hepatitis C|Human Immunodeficiency Virus|HIV Infections
Interventions: DRUG: Pegylated interferon alfa-2a + Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Tolerability of the Poly-ADP Ribose (PARP) Inhibitor With FOLFIRI in Subjects With Solid Tumor
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine, Infusional 5 Fluorouracil and Bevacizumab in Patients With Advanced Pancreas Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Bevacizumab|DRUG: Infusional 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Embolectomy, Ultrasound Assisted Thrombolysis or Heparin for Intermediate High Risk Pulmonary Embolism
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Embolism
Interventions: DEVICE: Ultrasound assisted Thrombolysis|DEVICE: Percutaneous Embolectomy|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Abatacept on Myocarditis in Rheumatoid Arthritis
Status: TERMINATED
Conditions: Rheumatoid Arthritis|Myocardial Inflammation
Interventions: DRUG: Abatacept|DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probe-based and Needle-based Confocal Laser Endomicroscopy During Gynaecological Procedures.
Status: COMPLETED
Conditions: Cervix Cancer|Endometrium Cancer|Ovarian Cancer|Carcinoma in Situ of Fallopian Tube
Interventions: DEVICE: Confocal Laser Endomicroscopy (CLE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Implantable Contraception on Type-2 DM and Metabolic Syndrome in Women With History of Gestational DM
Status: UNKNOWN
Conditions: Diabetes Mellitus|Metabolic Syndrome
Interventions: DEVICE: progestin implant|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Compare Pharmaceutical Economics and Efficacy of Sevoflurane With Low Fresh Gas Flow Balanced Anesthesia, Propofol Target Controlled Infusion Anesthesia and Propofol Induction Sevoflurane Maintenance Anesthesia
Status: COMPLETED
Conditions: Elective Laparoscopic Surgery
Interventions: DRUG: Sevoflurane Inhalational Induction and Maintenance|DRUG: Propofol Target Controlled Infusion for Induction and Maintenance|DRUG: Propofol Target Controlled Infusion for Induction and Sevoflurane Inhalation for Maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Norepinephrine Boluses in Liver Transplantation
Status: COMPLETED
Conditions: Living Donor Liver Transplantation|Norepinephrine Bolus|Postperfusion Syndrome
Interventions: DRUG: Norepinephrine boluses
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Investigate the Treatment Benefits of Probiotic Streptococcus Salivarius K12 for Hospitalised Patients (Non-ICU) With COVID-19
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Standard of care|DIETARY_SUPPLEMENT: BLIS K12
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fascial Release on Upper Cross Syndrome.
Status: COMPLETED
Conditions: Upper Cross Syndrome
Interventions: OTHER: Release of upper track of deep front fascial line|OTHER: Corrective exercises for upper crossed syndrome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Amivantamab, a Human Bispecific EGFR and cMet Antibody, in Participants With Advanced Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small-Cell Lung Cancer
Interventions: DRUG: Amivantamab|DRUG: Amivantamab|DRUG: Lazertinib|DRUG: Carboplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enzastaurin, Carboplatin, and Gemcitabine With or Without Bevacizumab in Treating Patients With Recurrent, Stage IIIB, or Stage IV Non-Small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Lung Cancer
Interventions: DRUG: bevacizumab|DRUG: carboplatin|DRUG: enzastaurin hydrochloride|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Superiority of MACI® Versus Microfracture Treatment in Patients With Symptomatic Articular Cartilage Defects in the Knee
Status: COMPLETED
Conditions: Articular Cartilage Defect
Interventions: BIOLOGICAL: autologous cultured chondrocytes on porcine collagen membrane|PROCEDURE: Microfracture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Cardiac Resynchronisation Therapy (CRT) Response Using High Frequency (HF) - ECG or Q-LV Guided Optimisation for Left Ventricular, Pacing Site.
Status: RECRUITING
Conditions: Heart Failure
Interventions: OTHER: High Frequency ECG Mapping|OTHER: Q-LV Measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Validation of a Non-Invasive Sham Technique
Status: UNKNOWN
Conditions: Acupuncture
Interventions: PROCEDURE: Acupuncture|PROCEDURE: Non-invasive Sham Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of CONvalescent Plasma in Patients With COVID-19 Treated With Mechanical Ventilation
Status: ACTIVE_NOT_RECRUITING
Conditions: Covid19|Mechanical Ventilation Complication|Corona Virus Infection|Respiratory Failure|SARS (Severe Acute Respiratory Syndrome)
Interventions: BIOLOGICAL: Convalescent Plasma|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incidence Of Mesh Infection After Hernioplasty In Obstructed and Strangulated Hernia Using Proline Mesh and Sutures
Status: NOT_YET_RECRUITING
Conditions: Incidence of Mesh Infection In Hernioplasty
Interventions: PROCEDURE: Proline mesh in hernioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Height Versus Height and Weight Based Spinal Bupivacaine on Maternal Haemodynamics for Elective Cesarean in Short Stature Patients
Status: COMPLETED
Conditions: Maternal Hypotension After Spinal Anesthesia
Interventions: DRUG: Hyperbaric bupivacaine spinal|DRUG: Hyperbaric bupivacaine spinal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of LYN-014 in Individuals With Opioid Use Disorder Who Are Stable on Methadone Therapy
Status: WITHDRAWN
Conditions: Opioid Use Disorder, Moderate
Interventions: DRUG: Levomethadone HCl|DRUG: Methadone|DRUG: Morphine Sulfate|DIAGNOSTIC_TEST: x-ray|DIAGNOSTIC_TEST: blood tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Amoxicillin-metronidazole Compared to Clindamycin in Patients With Periodontitis and Diabetes
Status: COMPLETED
Conditions: Periodontitis|Periodontal Pocket|Diabetes Mellitus
Interventions: DRUG: Amoxicillin 500 mg / Metronidazole 250 mg|DRUG: Clindamycin 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Doxorubicin Hydrochloride Liposome in Treating Women With Ductal Carcinoma in Situ Undergoing Surgery
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: pegylated liposomal doxorubicin hydrochloride|GENETIC: DNA methylation analysis|GENETIC: TdT-mediated dUTP nick end labeling assay|GENETIC: fluorescence in situ hybridization|GENETIC: loss of heterozygosity analysis|GENETIC: polymerase chain reaction|OTHER: immunoenzyme technique|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|PROCEDURE: breast duct lavage|PROCEDURE: neoadjuvant therapy|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Hydroxyethyl Starch and Renal Function After Hip Replacement Surgery
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Voluven (Hydroxyethyl starch 130/0,4)|DRUG: Sodium Chloride 9 mg/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Using Eye Mask and Earplugs on Prevention of Delirium
Status: UNKNOWN
Conditions: Delirium
Interventions: OTHER: eye mask and earplugs|OTHER: Nurse Education and Environmental Regulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oral Gallium Maltolate for the Treatment of Relapsed and Refractory Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: Gallium maltolate (500 mg)|DRUG: Gallium maltolate (1,000 mg)|DRUG: Gallium maltolate (1,500 mg)|DRUG: Gallium maltolate (2,000 mg)|DRUG: Gallium maltolate (2,500 mg)|DRUG: Gallium maltolate (recommended phase 2 dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b/2 Study of ADG116, ADG116 Combined With Anti-PD-1 Antibody or Anti-CD137 Antibody in Solid Tumors Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced/Metastatic Solid Tumors
Interventions: DRUG: ADG116|DRUG: ADG106|DRUG: anti PD1 drug
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Brain Imaging Study of Opioid (Morphine) and Non-opioid (Ketorolac) Conditioning Effects
Status: COMPLETED
Conditions: Healthy Controls
Interventions: RADIATION: Integrated MR-PET scan|DRUG: Ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety Study of Azimilide on the Incidence of Cardiovascular Hospitalizations/Emergency Department Visits or Cardiovascular Death in Patients With an Implantable Cardioverter Defibrillator (ICD) (SHIELD-2)
Status: TERMINATED
Conditions: Arrhythmias, Cardiac|Heart Diseases|Cardiovascular Diseases|Implantable Cardioverter Defibrillator
Interventions: DRUG: Azimilide Dihydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Regorafenib in Subjects With Gastrointestinal Stromal Tumors (GIST) Who Have Progressed After Standard Therapy (Managed Access Program)
Status: NO_LONGER_AVAILABLE
Conditions: Gastrointestinal Stromal Tumors
Interventions: DRUG: Regorafenib (BAY73-4506)
Study Type: EXPANDED_ACCESS
Clinical trial: A Study to Evaluate the Effects of a Marine Lipid Oil Concentrate Formulation on Inflammation
Status: TERMINATED
Conditions: Inflammation|Inflammatory Response
Interventions: DIETARY_SUPPLEMENT: Marine Lipid Oil Concentrate|DIETARY_SUPPLEMENT: Dietary Supplement|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Text Message-Based Nudges Prior to Primary Care Visits to Increase Care Gap Closure
Status: COMPLETED
Conditions: Pneumonia, Pneumococcal|Diabetes Mellitus|Breast Cancer|Colorectal Cancer
Interventions: BEHAVIORAL: Text message nudge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: EMI-EHP Weight Management and Type 2 Diabetes Pragmatic Trial
Status: TERMINATED
Conditions: Type 2 Diabetes|Obesity
Interventions: OTHER: Weight Management Program (WMP)|OTHER: Traditional care|DRUG: Phentermine / Topiramate Extended Release Oral Capsule|DRUG: naltrexone/bupropion extended-release|DRUG: liraglutide 3.0 mg|DRUG: Orlistat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Rosuvastatin/Ezetimib 20/10 mg and Atovastatin/Ezetimib 40/10 mg (TOLERANT Trial)
Status: RECRUITING
Conditions: Coronary Artery Disease|Dyslipidemias
Interventions: DRUG: a high dose of statin/ezetimib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Living in Full Even With Pain Study
Status: COMPLETED
Conditions: Musculoskeletal Pain|Chronic Pain
Interventions: BEHAVIORAL: Cognitive Therapy (CT)|BEHAVIORAL: Mindfulness Meditation (MM)|BEHAVIORAL: Activation Skills (AS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyperpolarized 13C MR Imaging of Lactate in Patients With Locally Advanced Cervical Cancer (LACC) Cervical Cancer
Status: TERMINATED
Conditions: Uterine Cervical Neoplasms
Interventions: DRUG: Hyperpolarized 13C-Pyruvate|DRUG: 18F-FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: The Effects of Functional Power Training on Frail and Pre-frail Community - Dwelling Older Adults in Singapore
Status: COMPLETED
Conditions: Frailty|Muscle Weakness
Interventions: OTHER: Functional Power Training|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Modulating the GIP System in Patients With Acromegaly Due to a Pituitary Tumor
Status: COMPLETED
Conditions: Acromegaly Due to Pituitary Adenoma
Interventions: OTHER: GIP-A|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase I Study of the Safety and Pharmacokinetics of Recombinant Human CD4-Immunoglobulin G (rCD4-IgG) Administered by Intravenous Bolus Injection in Combination With Oral Zidovudine in Patients With AIDS and AIDS-Related Complex
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: CD4-IgG|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: PH iWell Study to Compare an Online Interactive Technology to Self-directed Care in Overweight or Obese Individuals
Status: UNKNOWN
Conditions: Overweight|Obesity
Interventions: BEHAVIORAL: Technology assisted health behavior|BEHAVIORAL: Self directed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Interaction Between Oxytocin and Serotonin
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: oxytocin nasal spray|DRUG: intranasal placebo treatment (placebo-control for oxytocin)|DRUG: ATD treatment|DRUG: oral placebo treatment (placebo-control for ATD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Transcutaneous Vagal Nerve Stimulation on Reducing Oesophageal Pain Hypersensitivity
Status: UNKNOWN
Conditions: Esophageal Diseases
Interventions: DEVICE: Transcutaneous vagal nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on CAR-T Targeting Igβ Targets in Refractory Relapsed Non-Hodgkin's Lymphoma
Status: RECRUITING
Conditions: Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma
Interventions: DRUG: Chimeric Antigen Receptor T Cells (CAR-T) Targeting Igβ Targets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Emotional Dysregulation, Maladaptive Overcontrol in Anorexia - Effect of Radically Open Dialectical Behaviour Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Anorexia Nervosa|Anorexia in Adolescence|Anorexia Nervosa, Atypical
Interventions: BEHAVIORAL: Radically Open Dialectical Behaviour Therapy (RO-DBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CRS-207, Pembrolizumab, Ipilimumab, and Tadalafil in Metastatic Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Tadalafil|DRUG: Pembrolizumab|DRUG: Ipilimumab|DRUG: CRS-207
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes
Status: RECRUITING
Conditions: End-Stage Kidney Disease|End-Stage Renal Disease
Interventions: DRUG: Metoprolol Succinate|DRUG: Carvedilol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Simvastatin on Th17 Cytokines and Th17 Polarizing Cytokine in COPD Patients
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: simvastatin, placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Miconazole Oil Versus Vehicle on Fungal Infection of the Ear Canal (Otomycosis)
Status: COMPLETED
Conditions: Otomycosis
Interventions: DRUG: miconazole 2% oil|DRUG: vehicle oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: JAB-3312 Based Combination Therapy in Adult Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor|NSCLC
Interventions: DRUG: JAB-3312|DRUG: Binimetinib|DRUG: Pembrolizumab|DRUG: Sotorasib|DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetuximab & Nivolumab in Patients With Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Squamous Cell Carcinoma of the Oropharynx|Squamous Cell Carcinoma of the Larynx|Squamous Cell Carcinoma of the Oral Cavity|Squamous Cell Carcinoma of the Hypopharynx|Squamous Cell Carcinoma of the Paranasal Sinus|Head and Neck Squamous Cell Carcinoma|Squamous Cell Cancer|Head and Neck Carcinoma
Interventions: DRUG: Nivolumab|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel PET/CT Agents and MRS/MRI in Prostate CA and High Risk Prostate Cancer: An Inter-SPORE Collaboration
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DEVICE: Diagnostic Imaging: C11 choline PET; C11 acetate PET; and MRI Spectroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of a Model for Post-Anesthesia Troponin Increase and Heart Injury EStimation
Status: COMPLETED
Conditions: Postoperative Myocardial Ischemia
Interventions: DIAGNOSTIC_TEST: collection of cardiovascular risk scores and intraoperative cardiovascular parameters|DIAGNOSTIC_TEST: cardiac troponin assay|DIAGNOSTIC_TEST: Electrocardiogram
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: IRM Cardiaque en Respiration Libre Pour Des Patients Atteints de Dystrophinopathie sévère
Status: COMPLETED
Conditions: Duchenne or Severe Becker Myopathy
Interventions: DEVICE: Magnetic Resonance Cardiac Imaging (with Gadolinium)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of the Safety and Efficacy of REGN727/SAR236553 in Patients With HeFH Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Alirocumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Omega-3 Supplementation on Gene Expression in Type 2 Diabetics
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: omega-3|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Head-to-Head Comparison of All Botulinum Neurotoxin Type A Products for Glabellar Rhytides
Status: NOT_YET_RECRUITING
Conditions: Wrinkle
Interventions: DRUG: Botulinum toxin type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ropivacaine 0.2% Pre-Filled Dispenser for the Treatment of Postsurgical Pain in Patients Undergoing Cesarean Delivery
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Ropivacaine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Citrulline, Exercise Training and Muscle Strength in the Elderly
Status: COMPLETED
Conditions: Elderly Patients
Interventions: DIETARY_SUPPLEMENT: Citrulline|DIETARY_SUPPLEMENT: Non essential amino acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Radiofrequency Ablation in Treating Patients With Refractory or Advanced Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer|Malignant Mesothelioma|Metastatic Cancer|Thymoma and Thymic Carcinoma
Interventions: PROCEDURE: radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Controlled, Unblinded, Clinical Trial of the Acceptability and Efficacy of Non-Pharmaceutical Methods in Preventing Spread of Influenza Within the Family
Status: UNKNOWN
Conditions: Influenza
Interventions: BEHAVIORAL: sanitation and personal hygiene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Percutaneous Cryotherapy in the Treatment of Plexiform Neurofibromas and Unresectable Neurofibromas in Neurofibromatosis Type 1
Status: RECRUITING
Conditions: Neurofibroma|Neurofibroma, Plexiform
Interventions: DEVICE: Cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Dietary Supplementation With a Version of Anatabloc(R) in Subjects With Alzheimer's Disease
Status: TERMINATED
Conditions: Alzheimer Disease
Interventions: DIETARY_SUPPLEMENT: Anatabloc(R)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Safety, Tolerability, PK and Anti-tumor Activity of TRX-221 in EGFRm NSCLC Patients
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung|EGFR Mutant Advanced Non-Small Cell Lung Cancer
Interventions: DRUG: TRX-221
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Intranasal Ketamine vs. Intranasal Midazolam in Individuals With OCD
Status: TERMINATED
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: Intranasal Ketamine|DRUG: Intranasal Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Combination of Midodrine With Propranolol in Preventing First Bleed in Decompensated Cirrhotics With Severe Ascites.
Status: COMPLETED
Conditions: Decompensated Cirrhosis|Severe Ascites
Interventions: DRUG: Propranolol|DRUG: Midodrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Exposure of TA Following Administration of Either FX006 or TAcs in Patients With Bilateral Knee OA
Status: COMPLETED
Conditions: Bilateral Knee Osteoarthritis
Interventions: DRUG: FX006 32 mg|DRUG: TAcs 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of ASC40 Tablets in Combination With Bevacizumab in Subjects With rGBM
Status: RECRUITING
Conditions: Recurrent Glioblastoma
Interventions: DRUG: ASC40 tablets|DRUG: Placebo tablets|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improve Hysterosalpingographic Accuracy by Real-time Fluoroscopy
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: diagnose under real-time fluoroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Safety Study of Lirilumab in Combination With Nivolumab or in Combination With Nivolumab and Ipilimumab in Advanced and/or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: BIOLOGICAL: Lirilumab|BIOLOGICAL: Nivolumab|BIOLOGICAL: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ReSTOR Natural +3.0D Study In Japan
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: ACRYSOF Multifocal Single-piece Intraocular Lens (IOL) Model SN6AD1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trough Bronchoprotection Conferred by Levosalbutamol and Racemic Salbutamol
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: levosalbutamol|DRUG: racemic salbutamol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of OBINUTUZUMAB Combined to LENALIDOMIDE for the Treatment of Relapsed/Refractory Follicular and Aggressive B-cell Lymphoma
Status: COMPLETED
Conditions: Follicular Lymphoma Patients (Phase IB)|Follicular and Agressive (DLBCL&MCL) B-cell Lymphoma Patients (Phase II)
Interventions: DRUG: Lenalidomide and GA101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating NN1218 in Subjects With Type 1 and Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DRUG: Faster-acting insulin aspart|DRUG: insulin aspart|DRUG: Faster-acting insulin aspart|DRUG: Faster-acting insulin aspart|DRUG: Faster-acting insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Telehealth Advance Care Planning Intervention for Older Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: BEHAVIORAL: Telehealth
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Improving Accessibility and Personalization of CR for Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: BEHAVIORAL: Cognitive Remediation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of DCA for the Treatment of Brain Cancer
Status: COMPLETED
Conditions: Malignant Gliomas, Glioblastoma Multiforme
Interventions: DRUG: Dichloroacetate (DCA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Success Rate of Partial Pulpotomy Versus Complete Pulpotomy in Primary Molars Using NeoPUTTY MTA
Status: NOT_YET_RECRUITING
Conditions: Pulp Disease, Dental
Interventions: PROCEDURE: Partial Pulpotomy|PROCEDURE: Complete pulpotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perforomist Versus Foradil Evaluated by Inspiratory Capacity and High Resolution Computed Tomography (HRCT)
Status: WITHDRAWN
Conditions: Chronic Obstructive Pulmonary Disease|COPD|Chronic Bronchitis|Emphysema
Interventions: DRUG: formoterol fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: High-intensity Resistance Training in People With Multiple Sclerosis Experiencing Fatigue
Status: COMPLETED
Conditions: Multiple Sclerosis|Fatigue|Exercise Therapy|Resistance Training|Cytokines
Interventions: OTHER: High-intensity resistance training|OTHER: Low frequency of high-intensity resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Multibranched Stent Graft System in the Treatment of Thoracoabdominal Aortic Aneurysm
Status: RECRUITING
Conditions: Thoracoabdominal Aortic Aneurysm
Interventions: DEVICE: multibranched stent graft system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Anodal Transcranial Direct Current Stimulation (t-DCS) and Sham Stimulation in Patients With Treatment-resistant Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: Transcranial direct current stimulation (t-DCS)|OTHER: Sham Controlled Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of EEG in Identifying Cognitive Changes in Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease|Cognition Disorder|EEG With Abnormally Slow Frequencies
Interventions: OTHER: tDCS + tredmill training (Standart trehab training)|OTHER: Cognitite-motor Dual Task Training (DT training)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Relationship Between Ultrasonographic Findings and Sleep Quality in Carpal Tunnel Syndrome
Status: RECRUITING
Conditions: Musculoskeletal Diseases|Median Nerve Disease|Carpal Tunnel Syndrome|Ultrasound|Sleep Quality
Interventions: OTHER: Assessment of Sleep Quality|OTHER: Assessment of Sleep Quality
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess an Anti-Trop2 Antibody Drug Conjugate in Relapsed or Refractory Solid Tumors
Status: WITHDRAWN
Conditions: Relapsed Solid Neoplasm|Refractory Cancer|Solid Tumor, Adult
Interventions: BIOLOGICAL: STI-3258
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT