pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Palbociclib and Binimetinib in RAS-Mutant Cancers, A ComboMATCH Treatment Trial
Status: RECRUITING
Conditions: Exocrine Pancreas Carcinoma|Malignant Solid Neoplasm|Ovarian Low Grade Serous Adenocarcinoma|Stage IV Ovarian Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8
Interventions: DRUG: Binimetinib|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Participatory Program Evaluation of a Virtual Trauma Support Program for Autistic Adults
Status: RECRUITING
Conditions: Autism|Trauma|Posttraumatic Stress Disorder|Posttraumatic Stress Symptom
Interventions: BEHAVIORAL: Written Exposure Therapy (WET) via telehealth
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Harmonizing RCT-Duplicate Emulations In A Real World Replication Program (HARRP)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Canagliflozin|DRUG: DPP4 inhibitor|DRUG: Liraglutide|DRUG: Saxagliptin|DRUG: 2nd generation Sulfonylurea
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: One Week Comparison Study of PTH and PTHrP Infusions
Status: WITHDRAWN
Conditions: Osteoporosis|Hypercalcemia of Malignancy|Hyperparathyroidism|Bone Diseases, Endocrine
Interventions: DRUG: Parathyroid Hormone-related Protein (1-36)|DRUG: parathyroid hormone (1-34)|DRUG: PTH (1-34) and PTHrP (1-36)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: A Phase III Study to Evaluate the Efficacy and Safety of GSK1358820 in Subjects With Post-stroke Upper Limb Spasticity
Status: COMPLETED
Conditions: Spasticity, Post-Stroke
Interventions: DRUG: Botulinum toxin A (GSK1358820)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure
Status: RECRUITING
Conditions: Opioid Use|Opioid Dependence|Opioid-use Disorder|Narcotic Use|Back Pain|Back Injuries|Chronic Pain|Chronic Low-back Pain|Pain, Chronic|Pain;Back Low;Chronic|Pain, Back
Interventions: DRUG: Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet|DRUG: Naproxen 500 Mg|DRUG: Opioids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab (MK-3475) Versus Placebo Following Surgery and Radiation in Participants With Locally Advanced Cutaneous Squamous Cell Carcinoma (MK-3475-630/KEYNOTE-630)
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Squamous Cell
Interventions: BIOLOGICAL: Pembrolizumab 400 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CD19 Targeted Universal Chimeric Antigen Receptor T Cells Injection for CD19+ Refractory/Relapsed B-cell Malignancies
Status: RECRUITING
Conditions: Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia|Relapsed or Refractory B-cell Non-hodgkin Lymphoma
Interventions: BIOLOGICAL: Anti-CD19 Universal CAR-T Cells injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COMFORT Caregiver Intervention in Improving Communication and Reducing Distress in Caregivers of Patients With Lung Cancer
Status: COMPLETED
Conditions: Caregiver
Interventions: OTHER: Communication Intervention|OTHER: Educational Intervention|OTHER: Psychosocial Support for Caregiver|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acetic Acid 2% Solution for Skin Ulcers
Status: NOT_YET_RECRUITING
Conditions: Ulcer, Skin
Interventions: DRUG: Acetic Acid|DRUG: Prontosan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sustained Natural Apophyseal Glides and Mechanical Cervical Traction in the Management of Cervical Radiculopathy
Status: COMPLETED
Conditions: Cervical Radiculopathy
Interventions: OTHER: Sustained Natural Apophyseal Glides|OTHER: Mechanical Cervical Traction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutrition, Exercise, and Wellness Treatment (NEW Tx) for Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: OTHER: Nutrition, Exercise, and Wellness (NEW) psychotherapy|DRUG: Typically consists of at least one FDA-approved mood stabilizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Safety and Efficacy of Convalescent Plasma in Patients With Severe COVID-19 Disease
Status: COMPLETED
Conditions: Severe COVID-19 Disease
Interventions: BIOLOGICAL: Biological
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Soft Contact Lens Use With 7 Day Extended Wear
Status: COMPLETED
Conditions: Ametropia
Interventions: DEVICE: VISA (comfilcon A) Silicone Hydrogel Soft contact lens|DEVICE: Acuvue 2 Soft Contact Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transformatıonal Learnıng Theory on Infertılıty and Stigma in Infertılıty Women
Status: UNKNOWN
Conditions: Infertility, Female|Stigma, Social
Interventions: OTHER: EDUCATIONAL PROGRAM CREATED ACCORDING TO TRANSFORMATIONAL LEARNING THEORY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Comparison of Ropivacaine and Liposomal Bupivacaine for Total Knee Arthroplasty
Status: WITHDRAWN
Conditions: Arthroplasty|Replacement|Knee
Interventions: DRUG: liposomal bupivacaine Periarticular injection|DRUG: Ropivacaine Periarticular Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BEATRICE Study: A Study of Bevacizumab (Avastin) Adjuvant Therapy in Triple Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Bevacizumab|DRUG: Standard adjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Mesenchymal Stem Cells to Treat Avascular Necrosis of the Hip
Status: COMPLETED
Conditions: Avascular Necrosis of the Femoral Head
Interventions: BIOLOGICAL: Cultured autologous Mesenchymal Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ridge Preservation With Moldable Beta-tricalcium Phosphate Bone Substitute on Non-containable Non-Molar Extraction Sites
Status: TERMINATED
Conditions: Alveolar Ridge Preservation|Dental Implants
Interventions: DEVICE: easy-graft CLASSIC (beta-Tricalcium Phosphate)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation and Expansion Study of FLX475 Monotherapy and in Combination With Pembrolizumab
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Cancer
Interventions: DRUG: FLX475|DRUG: pembrolizumab (KEYTRUDA®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Continuous Wound Catheter Infusion Versus Continuous Epidural Infusion in Abdominal Surgery
Status: COMPLETED
Conditions: Upper Gastrointestinal Surgery|Post-operative Analgesia|Wound Infusion Catheter|Upper Midline Incision
Interventions: OTHER: Wound catheter infusion|OTHER: Epidural infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of LASER Photobiomodulation Therapy on Chronic Pain and Opioid Weaning
Status: TERMINATED
Conditions: Chronic Pain
Interventions: DEVICE: LightForce EXPi
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Systemic Inflammation on Emotion and Cognition in Patients With Mood Disorder - A Vaccine Study
Status: TERMINATED
Conditions: Major Depressive Disorder
Interventions: BIOLOGICAL: S.typhi Injection|BIOLOGICAL: Normal Saline Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Relationship of Psychological Factors and Sleep Quality With the Severity of Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome|Depressive Symptoms|Sleepiness|Anxiety|Sleep|Pain, Neuropathic
Interventions: BEHAVIORAL: cross-sectional survey study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Comparing Megestrol Acetate at 800 mg/Day, and Placebo in AIDS Patients With Anorexia and Cachexia
Status: COMPLETED
Conditions: Anorexia|Cachexia|HIV Infections
Interventions: DRUG: Megestrol acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Changes in Dyspnea, Activity and Sleep in COPD by Video-Based Breathing Exercises
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: Video-Based Breathing Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Supreme LMA and Endotracheal Intubation Use in Caesarean Section
Status: COMPLETED
Conditions: Complications; Cesarean Section
Interventions: DEVICE: Endotracheal intubation|DEVICE: Supreme Laryngeal Mask Airway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Oral Belumosudil on Inhibition of Various Proteins in the Fed State in Healthy Male Subjects
Status: COMPLETED
Conditions: Immune System Disorder (Healthy Volunteers)
Interventions: DRUG: Belumosudil|DRUG: UGT1A1 victim drug|DRUG: P-gp victim drug|DRUG: OATP1B1/BCRP victim drug
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Boarding Ring Glasses Versus Placebo Glasses or Not Glasses in the Treatment of Vestibular Neuritis
Status: RECRUITING
Conditions: Vestibular Neuritis
Interventions: DIAGNOSTIC_TEST: Caloric test|DIAGNOSTIC_TEST: Measurement of the speed of Nystagmus|DIAGNOSTIC_TEST: Angle of deviation at Fukuda|DIAGNOSTIC_TEST: Alexander's degree of nystagmus|OTHER: EHTEV questionnaire|OTHER: EEV questionnaire|OTHER: anxiety VAS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Electrical Stimulation and Eccentric Exercise for Anterior Cruciate Ligament (ACL) Injury
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injury
Interventions: DEVICE: Electrical Stimulation|OTHER: Eccentric Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Repetitive Magnetic Stimulation for Strength Training of the Quadriceps Muscle
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Repetitive magnetic stimulation to the quadriceps
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective, Observational, Real-world Oral Malignant Tumors Study
Status: RECRUITING
Conditions: Head and Neck Neoplasms|Quality of Life|Postoperative Complications
Interventions: PROCEDURE: resection|RADIATION: adjuvant radiotherapy|DRUG: neoadjuvant chemotherapy or adjuvant chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment
Status: COMPLETED
Conditions: Apical Periodontitis
Interventions: PROCEDURE: Root canal treatment with 5% NaOCl|PROCEDURE: Root canal treatment with 1% NaOCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of Human Cord Blood Derived, Culture Expanded Natural Killer Cell (PNK-007) Infusion With Subcutaneous Recombinant Human IL-2 (rhIL-2) in Adults With Relapsed and/or Refractory Acute Myeloid Leukemia (AML)
Status: TERMINATED
Conditions: Leukemia, Myeloid, Acute
Interventions: BIOLOGICAL: PNK-007|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Human recombinant Interleukin-2 (rhIL-2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The HPV Self-test as a Test of Cure in Madagascar
Status: COMPLETED
Conditions: Human Papilloma Virus Infection|Cervical Intraepithelial Neoplasia Grade 2/3
Interventions: DEVICE: HPV test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Levetiracetam, Lacosamide and Ketamine as Adjunctive Treatment of Refractory Status Epilepticus
Status: WITHDRAWN
Conditions: Epilepsy|Status Epilepticus
Interventions: DRUG: levetiracetam|DRUG: lacosamide|DRUG: Ketamine|DRUG: Phenobarbital
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characteristics and Dynamics of TCR Repertoire in Patients With Hematological Malignancies After Allo-HSCT
Status: COMPLETED
Conditions: Hematologic Neoplasms|Hematopoietic Stem Cell Transplantation|Graft Vs Host Disease|Recurrence
Interventions: OTHER: Myeloablative Hematopoietic Stem Cell Transplantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Different Hyaluronic Acid Tear Substitutes Formulations in Evaporative Dry Eye
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Icross tear substitute|DRUG: Hyabak tear substitute
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Clevudine and Peg-interferon in Sequence Compared With Clevudine Alone in the Patients With HBeAg(+) Chronic Hepatitis B or Clevudine and Peg-interferon Sequential Treatment in Patients With Chronic Hepatitis B Who Have HBeAg(+)
Status: COMPLETED
Conditions: HBeAg(+) Chronic Hepatitis B
Interventions: DRUG: Clevudine|DRUG: Clevudine + Peg-interferon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resistance Training and Amino Pyridine in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: SR-fampridine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing a Mobile Mindfulness Intervention for ICU Survivors
Status: COMPLETED
Conditions: Cardiorespiratory Failure
Interventions: BEHAVIORAL: Mobile mindfulness-based training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Intraoperative Fluid Therapy on Acute Kidney Injury After Thoracoscopic Lobectomy
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: PROCEDURE: fluid therapy during operation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single, Oral Escalating Doses of GSK2647544 in Healthy Volunteers
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: GSK2647544|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Molecular and Functional Brain Imaging Study in Individuals With Down Syndrome and Healthy Controls Following Single Dose RG1662
Status: COMPLETED
Conditions: Healthy Volunteer, Down Syndrome
Interventions: DRUG: RG1662|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: The Impact of a Helplessness and Recovery of an Empowerment Intervention on People Diagnosed With Schizophrenia: Findings From a Randomized Controlled Trial
Status: COMPLETED
Conditions: Psychotic Disorders
Interventions: BEHAVIORAL: Empowerment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Different Forms of TAK-994 in Healthy Adults
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: TAK-994|DRUG: TAK-994|DRUG: TAK-994|DRUG: TAK-994|DRUG: TAK-994
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Randomised Controlled Platform Trial Testing Treatments in Metastatic Hormone Sensitive Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer Metastatic
Interventions: RADIATION: Stereotactic Ablative Body Radiotherapy (SABR)|OTHER: 177Lu-PSMA-617|DRUG: Niraparib and Abiraterone Acetate Dual Action Tablet DAT|DRUG: Abiraterone Acetate|DRUG: Apalutamide|DRUG: Androgen Deprivation Therapy (ADT)|DRUG: Androgen Receptor Signalling Inhibitor (ARSI)|RADIATION: Local Radiotherapy|DRUG: Prednisolone|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Visual Laryngeal Mask Airway Combined With Endotracheal Intubation in General Anesthesia
Status: UNKNOWN
Conditions: General Anesthesia|Laryngeal Mask|Endotracheal Intubation|Surgery
Interventions: DEVICE: visual laryngeal mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Galantamine and CDP-choline (Citicoline) to Treat Adults With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Galantamine|DRUG: CDP-choline|DRUG: Placebo|DRUG: risperidone, olanzapine, quetiapine, ziprasidone, and/or aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Frequency Specific Microcurrent Therapy for Mild Traumatic Brain Injury
Status: NOT_YET_RECRUITING
Conditions: Trauma, Head|Headaches Posttraumatic|Dizziness|Brain Concussion|Frequency Specific Microcurrent Therapy
Interventions: DEVICE: Frequency specific microcurrent therapy|DEVICE: Sham Frequency specific microcurrent therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thalidomide in Treating Patients With Recurrent or Persistent Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Adenoacanthoma|Endometrial Adenocarcinoma|Endometrial Adenosquamous Cell Carcinoma|Endometrial Clear Cell Carcinoma|Endometrial Papillary Serous Carcinoma|Recurrent Endometrial Carcinoma
Interventions: DRUG: thalidomide|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Gilteritinib, Venetoclax and Azacitidine as a Combined Treatment for People Newly Diagnosed With Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia (AML)|FLT3-mutated Acute Myeloid Leukemia
Interventions: DRUG: Gilteritinib|DRUG: Venetoclax|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of T Cells Targeting B-Cell Maturation Antigen for Previously Treated Multiple Myeloma
Status: COMPLETED
Conditions: Myeloma, Plasma-Cell|Myeloma-Multiple
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|BIOLOGICAL: Anti-B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individual Preoperative Planning for RSA
Status: UNKNOWN
Conditions: Shoulder Osteoarthritis|Proximal Humeral Fracture|Avascular Necrosis of Humerus
Interventions: PROCEDURE: reverse shoulder arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Feasibility Study of the PLAR Implant and Delivery System to Treat Functional Mitral Regurgitation ( EXPLORE FMR )
Status: WITHDRAWN
Conditions: Functional Mitral Regurgitation
Interventions: DEVICE: Transcatheter mitral valve repair
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Combination of CPT-11 and LoHP vs Combination of 5-FU, Leucovorin and LoHP as 1st Line Treatment in Gastric Patients
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: Irinotecan|DRUG: Oxaliplatin|DRUG: Fluorouracil|DRUG: Leucovorin|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fast-Acting Insulin Aspart and Insulin Pump Settings
Status: UNKNOWN
Conditions: Type 1 Diabetes
Interventions: DRUG: Insulin aspart|DRUG: Fast-acting insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Education Given According to the Health Promotion Model on Premenstrual Symptoms, Emotional Eating Behavior and Perceived Stress
Status: RECRUITING
Conditions: Premenstrual Syndrome|Emotional Disorder|Perceived Stress
Interventions: BEHAVIORAL: Training given according to the health promotion model by applying the Philips 66 technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Letrozole or Laparoscopic Ovarian Diathermy for Women With CC Resistant Polycystic Ovary Syndrome.
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Letrozole|PROCEDURE: Laparoscopic ovarian diathermy (LOD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Assessing Efficacy of Brivaracetam in Subjects With Persistent Pain After Shingles (Post-herpetic Neuralgia)
Status: COMPLETED
Conditions: Neuralgia, Postherpetic
Interventions: DRUG: Placebo|DRUG: Brivaracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subject Reported Outcomes With Use of Adapalene 0.3% - Benzoyl Peroxide (BPO) 2.5% in Dark Skin Acne
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Adapalene 0.3% / BPO 2.5% gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Aronia Juice Polyphenols on Cardiovascular Disease Risk
Status: UNKNOWN
Conditions: Hypertension|Overweight
Interventions: DIETARY_SUPPLEMENT: Pure Aronia juice|DIETARY_SUPPLEMENT: Aronia juice-based beverage|DIETARY_SUPPLEMENT: Placebo beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CM for Patients With ALD After Liver Transplant
Status: RECRUITING
Conditions: Alcohol Use Disorder|Alcohol; Liver|Post Liver Transplant|Contingency Management|Alcohol Liver Disease
Interventions: BEHAVIORAL: Contingency Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS Survivors
Status: COMPLETED
Conditions: Distress|Depression|Grief
Interventions: DRUG: Psilocybin|BEHAVIORAL: Modified brief Supportive Expressive Group Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Comparison of Tiotropium Inhalation Solution (Respimat Inhaler) and Spiriva HandiHaler in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium|DEVICE: Respimat SMI|DEVICE: HandiHaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Cortical Bone Trajectory Screws vs. Traditional Pedicle Screws Fixation
Status: UNKNOWN
Conditions: Spinal Stenosis Lumbar|Lumbar Disc Herniation|Intervertebral Disc Degeneration
Interventions: PROCEDURE: cortical bone trajectory screws|PROCEDURE: pedicle screws
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FRAIL-IMMUNE (GORTEC 2018-03) - Combination of Durvalumab With Carboplatin/Paclitaxel
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Durvalumab with Carboplatin/Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Varying Injection Schedules of TDENV-PIV Vaccine With AS03B Adjuvant and Placebo in Healthy US Adults
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: TDENV-PIV with AS03B adjuvant. Placebo: 0.9% Sodium Chloride Solution.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Acute Asthma in ER With Combination of Systemic Steroids and Inhaled Steroids
Status: UNKNOWN
Conditions: Asthma Exacerbation
Interventions: DRUG: inhalation of corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SKAMo-2: the Real-life Test of Continuous Photoacoustic Signal by Neogly in Patients With Type I Diabetes
Status: RECRUITING
Conditions: Diabetes
Interventions: DEVICE: Non-invasive continuous monitoring device to record photoacoustic signal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Evaluation of Clinical Equivalence Between Two Linaclotide Products in the Treatment of Chronic Idiopathic Constipation
Status: UNKNOWN
Conditions: Chronic Idiopathic Constipation
Interventions: DRUG: Linaclotide|DRUG: LINZESS®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Using Customized Insoles With Anterior or Posterior Plantar Support in Cross-pelvis Syndrome and Perception of Body Alignment in Young Adults: a Randomized Clinical Trial
Status: UNKNOWN
Conditions: Crossed Pelvis Syndrome
Interventions: OTHER: Personalized Insole Group|OTHER: Placebo Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Oral Carbohydrate Loading Versus Fasting in Patients Undergoing Major Abdominal Surgery
Status: RECRUITING
Conditions: Carbohydrate|Fasting|Major Abdominal Surgery
Interventions: OTHER: Placebo drink|DIETARY_SUPPLEMENT: Carbohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: EFFICACY OF THE SLEEVE GASTROPLASTY WITH THE ENDOSCOPIC SYSTEM OVERSTICH SX ON WEIGHT LOSS AND REDUCTION OF CO-MORBIDITY FOR OBESE PATIENTS
Status: COMPLETED
Conditions: Obesity
Interventions: PROCEDURE: the sleeve gastroplasty with the endoscopic system Overstich SX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Evaluate 99mTc-MIP-1404 SPECT/CT Imaging in Men With Biopsy Proven Low-Grade Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: 99mTc-MIP-1404 Injection|DIAGNOSTIC_TEST: Whole-Body Planar and pelvic SPECT/CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study for the Adjuvant Treatment of Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: Carboplatin|DRUG: Trastuzumab|DRUG: Pertuzumab|DRUG: Nab paclitaxel|DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: Docetaxel|DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: Nab paclitaxel|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Conditions During Vocal Cord Surgery Requiring Jet Ventilation With Moderate vs. Deep Neuromuscular Block
Status: TERMINATED
Conditions: High-Frequency Jet Ventilation|Vocal Cord Resection
Interventions: DRUG: Rocuronium bromide 0.5 mg/kg|DRUG: Rocuronium bromide 1.0 mg/kg|DRUG: Sugammadex sodium 2 mg/kg|DRUG: Sugammadex sodium 4 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of RO4917838 in Participants With Persistent, Predominant Negative Symptoms of Schizophrenia (NN25310)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Placebo|DRUG: RO4917838|DRUG: Antipshychotics (Standard of Care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ABNCoV2 Vaccine in SARS-CoV-2 (COVID-19) Seronegative and Seropositive Adult Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19 Disease
Interventions: BIOLOGICAL: ABNCoV2 100ug|BIOLOGICAL: ABNCoV2 50ug
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Three Modalities of Treatment in Operable and Resectable Stage IIIA (T1-3, N2) Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Cisplatin-Gemzar|DRUG: Cisplatin-Navelbine-Radiotherapy|DRUG: Carboplatin-Taxol-Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine and Paclitaxel vs Gemcitabine Alone After FOLFIRINOX Failure in Metastatic Pancreatic Ductal Adenocarcinoma
Status: COMPLETED
Conditions: Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: Gemcitabine|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Ringer Lactate and Isotonic Acetate Solution as Perioperative Maintenance Fluid for Children
Status: UNKNOWN
Conditions: Hyponatremia
Interventions: BIOLOGICAL: Ringer Lactate|BIOLOGICAL: Plasmalyte
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Single Dose Trial of Recombinant Factor VIII (N8) in Japanese Subjects With Haemophilia A: An Extension to Trial NN7008-3543
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A
Interventions: DRUG: turoctocog alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-oxygenation With Facemask Oxygen vs High-flow Nasal Oxygen vs High-flow Nasal Oxygen Plus Mouthpiece Oxygen
Status: COMPLETED
Conditions: Apnea|Respiration; Arrest|Anesthesia
Interventions: OTHER: Pre-oxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The PRIORi-T Trial--Prospective Randomized Investigation of Radiofrequency Targeted Vertebral Augmentation
Status: WITHDRAWN
Conditions: Painful Osteoporotic Vertebral Compression Fractures (VCF)
Interventions: DEVICE: Vertebral Augmentation (STABILIT)|OTHER: Non-operative Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanistic Studies of Psilocybin in Headache Disorders
Status: NOT_YET_RECRUITING
Conditions: Migraine
Interventions: DRUG: Psilocybin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of a Long-term Grapefruit Juice Consumption on Vascular Protection and Bone Metabolism
Status: COMPLETED
Conditions: Post-menopausal Status
Interventions: BEHAVIORAL: Long-term grapefruit juice consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Oral Curcumin on Heme Oxygenase-1 (HO-1) in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: curcumin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of EN3835 in Participants With Frozen Shoulder
Status: COMPLETED
Conditions: Adhesive Capsulitis|Frozen Shoulder
Interventions: DRUG: EN3835|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab and Olaparib in Bile Duct Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cholangiocarcinoma
Interventions: DRUG: Pembrolizumab|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Rabeprazole and Pantoprazole on Stomach Acid and Esophageal Acid Exposure in Patients With Gastroesophageal Reflux Disease (GERD) and a History of Nighttime Heartburn
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: rabeprazole and pantoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effects of Dietary Supplement Drinks on Sleep, Stress and Mood
Status: RECRUITING
Conditions: Sleep|Mood|Stress
Interventions: DIETARY_SUPPLEMENT: Dietary supplement liquid shot beverage products
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of Oral SCIO-469 in Relapsed, Refractory Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: SCIO-469|DRUG: SCIO-469 and bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Radiotherapy Plus Iressa or Radiotherapy Plus Cisplatin and Iressa for Advanced Head & Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: Gefitinib|DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ARRY-438162 in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: ARRY-438162, MEK inhibitor; oral|DRUG: Placebo; oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Lower Limb Spasticity
Status: ACTIVE_NOT_RECRUITING
Conditions: Spasticity
Interventions: DRUG: Phase 2; Low Dose MYOBLOC|DRUG: Phase 2; High Dose MYOBLOC|DRUG: Phase 2; Placebo|DRUG: Phase 3; MYOBLOC|DRUG: Phase 3; Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Potential of Givinostat as DDI Victim in Co-administration P-gp Inhibitor (Part 2)
Status: COMPLETED
Conditions: Drug Drug Interaction
Interventions: DRUG: Givinostat|DRUG: Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate Safety and Response to 1 or 2 g Rectal Suppositories Containing 5 or 10 mg NRL001.
Status: COMPLETED
Conditions: Fecal Incontinence
Interventions: DRUG: NRL001|DRUG: NRL001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of RWJ-333369 as add-on Therapy in the Treatment of Partial Onset Seizures.
Status: COMPLETED
Conditions: Epilepsy|Epilepsy, Focal|Seizure Disorder|Complex Partial Seizures|Epilepsy, Complex Partial
Interventions: DRUG: RWJ-333369
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Do Single Use Negative Pressure Dressings Reduce Wound Complications in Obese Women After Cesarean Delivery
Status: TERMINATED
Conditions: Obesity|Surgical Site Infections|Wound Complications|Complications; Cesarean Section
Interventions: DEVICE: Standard Dressing|DEVICE: Negative Pressure Wound Therapy Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Zotarolimus-Eluting Stent Versus Sirolimus-Eluting Stent and PacliTaxel-Eluting Stent for Coronary Lesions
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Endeavor|DEVICE: Cypher|DEVICE: Taxus Liberte
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Strategies for Endocervical Canal Investigation in Women With Abnormal Screening Cytology and Negative Colposcopy
Status: COMPLETED
Conditions: Diagnoses Disease|Screening|HSIL of Cervix|Cervical Cancer
Interventions: DIAGNOSTIC_TEST: Endocervical liquid-base cytology|DIAGNOSTIC_TEST: Endocervical cell block|DIAGNOSTIC_TEST: Endocervical curettage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Efficacy and Safety of Different Human Thrombopoietin (rhTPO) Regimens in the Treatment of Patients With Primary Immune Thrombocytopenia (ITP)
Status: COMPLETED
Conditions: ITP
Interventions: DRUG: TPO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess Pharmacokinetics, Safety and Tolerability of TEV-48125 in Japanese and Caucasian Healthy Subjects After a Single Subcutaneous (SC) Administration of TEV-48125
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: TEV-48125 - 1|DRUG: TEV-48125 - 2|DRUG: TEV-48125 - 3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: AMD3100 (Plerixafor) in Multiple Myeloma (MM) or Non-Hodgkin's Lymphoma (NHL) Patients Predicted to be Unable to Mobilize With G-CSF Alone
Status: TERMINATED
Conditions: Multiple Myeloma|Lymphoma, Non-Hodgkin's
Interventions: DRUG: G-CSF plus plerixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Corfluvec Vaccine for the Prevention of COVID-19 in Healthy Volunteers
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Corfluvec component 1 low dose|BIOLOGICAL: Corfluvec component 2 low dose|BIOLOGICAL: Corfluvec component 1 high dose|BIOLOGICAL: Corfluvec component 2 high dose|BIOLOGICAL: Corfluvec low dose|BIOLOGICAL: Corfluvec high dose|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Alveolar Ridge and Soft Tissue Augmentation Using Graft From the Maxillary Tuberosity
Status: ACTIVE_NOT_RECRUITING
Conditions: Immediate Implant Placement
Interventions: PROCEDURE: maxillary tuberosity bone graft (autogenous graft)|PROCEDURE: Bone graft (xenograft)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effect of Dietary Supplement VSL#3 on Cognition and Mood in Healthy Older Adults
Status: UNKNOWN
Conditions: Alteration of Cognitive Function|Disturbance in Affect (Finding)
Interventions: DIETARY_SUPPLEMENT: VSL#3|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mechanistic Loop Resolution Strategy for Short-type Single Balloon Enteroscopy
Status: COMPLETED
Conditions: Choledocholithiasis|Bile Duct Neoplasms|Biliary Tract Diseases|Roux-en-Y Anastomosis
Interventions: PROCEDURE: Single balloon enteroscopy assisted ERCP using a mechanistic loop resolution strategy group
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Zimura™in Combination With Anti-VEGF Therapy in Patients With Neovascular AMD
Status: TERMINATED
Conditions: Macular Degeneration
Interventions: DRUG: Zimura|DRUG: Avastin|DRUG: Lucentis|DRUG: Eylea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 11C-Metomidate PET/CT for Endocrine Hypertension and Characterisation of Adrenal Tumours
Status: RECRUITING
Conditions: Primary Aldosteronism Due to Aldosterone Producing Adenoma|Primary Aldosteronism|Adrenal Tumors
Interventions: COMBINATION_PRODUCT: 11C-Metomidate PET/CT imaging at Clinical Imaging Research Centre
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Biomarkers in Predicting Neurotoxicity in Patients With Colorectal Cancer Receiving Oxaliplatin
Status: UNKNOWN
Conditions: Chemotherapeutic Agent Toxicity|Colorectal Cancer|Neurotoxicity
Interventions: DRUG: FOLFOX regimen|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin|GENETIC: gene expression analysis|GENETIC: protein expression analysis|GENETIC: proteomic profiling|OTHER: laboratory biomarker analysis|OTHER: pharmacogenomic studies
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Lusutrombopag in the Treatment of Immune Thrombocytopenia (ITP)
Status: RECRUITING
Conditions: Idiopathic Thrombocytopenic Purpura|Immune Thrombocytopenia
Interventions: DRUG: Lusutrombopag Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Frequency of Screening and SBT Technique Trial
Status: UNKNOWN
Conditions: Critically Ill
Interventions: PROCEDURE: Once daily screening|PROCEDURE: Twice daily screening|PROCEDURE: PS SBTs|PROCEDURE: T-piece SBTs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Assessment of Lipoprotein(a) and Endogenous Fibrinolysis in Atherosclerotic Cardiovascular Disease/Aortic Valve Disease
Status: RECRUITING
Conditions: Atherosclerosis|Aortic Valve Disease
Interventions: DIAGNOSTIC_TEST: Thrombotic assessment|DIAGNOSTIC_TEST: Measurement of Lp(a)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Thalidomide, Lenalidomide, and Rituximab for Previously Treated Waldenstrom Macroglobulinemia
Status: TERMINATED
Conditions: Waldenstrom Macroglobulinemia
Interventions: DRUG: Thalidomide|DRUG: Lenalidomide|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT