pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of ATB1651 in Adults With Mild to Moderate Onychomycosis
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: ATB1651, 2 mg/mL|DRUG: ATB1651, 5 mg/mL|DRUG: ATB1651, 10 mg/mL|DRUG: ATB1651, 20 mg/mL|DRUG: ATB1651, 30 mg/mL|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Intraocular Pressure (IOP)-Lowering Efficacy of AL-39256 in Patients With Open-Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: AL-39256 Ophthalmic Suspension, 1%|DRUG: Latanoprost Ophthalmic Solution, 0.005%|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of the Retropubic (TVT) With the Transobturator Sling Operation in the Treatment of Female Stress Urinary Incontinence or Stress Dominated Mixed Urinary Incontinence
Status: TERMINATED
Conditions: Stress Urinary Incontinence
Interventions: PROCEDURE: midurethral sling procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Teaching Neuraxial Ultrasonography With a Virtual Reality Simulator of Spine
Status: NOT_YET_RECRUITING
Conditions: Neuraxial Ultrasonography
Interventions: OTHER: Teaching with VR spine simulator|OTHER: Traditional didactic teaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effectiveness of Smart-Video Based Game Therapy and Otago-Based Structured Exercises in Women With Osteoporosis
Status: NOT_YET_RECRUITING
Conditions: Osteoporosis
Interventions: DEVICE: Smart-Video Based Game Therapy|OTHER: Otago Based Structured Exercise|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Topical Methotrexate Gel 1% Coupled With Microneedling in Treatment of Warts
Status: UNKNOWN
Conditions: Warts
Interventions: COMBINATION_PRODUCT: topical methotrexate hydrogel 1% coupled with microneedling.|OTHER: Liquid nitrogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Acceptability of Pharmacologic Treatment for Methamphetamine Dependence Among MSM
Status: COMPLETED
Conditions: Substance Abuse|HIV Infections
Interventions: DRUG: Bupropion|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Front Line Therapy With Nivolumab and Salvage Nivolumab + Ipilimumab in Patients With Advanced Renal Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Renal Cell Carcinoma
Interventions: DRUG: Nivolumab 240 mg|DRUG: Ipilimumab 1mg/kg|DRUG: Nivolumab 3mg/kg|DRUG: Nivolumab 360mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Embolization Before Ablation of Renal Cell Carcinoma (EMBARC)"
Status: RECRUITING
Conditions: Renal Cell Carcinoma (RCC)
Interventions: PROCEDURE: Trans-arterial embolization (TAE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 5-FU Based Maintenance Therapy in RAS Wild Type Metastatic Colorectal Cancer After Induction With FOLFOX Plus Panitumumab
Status: TERMINATED
Conditions: Colorectal Adenocarcinoma|RAS Wild Type|Stage III Colorectal Cancer AJCC v7|Stage IIIA Colorectal Cancer AJCC v7|Stage IIIB Colorectal Cancer AJCC v7|Stage IIIC Colorectal Cancer AJCC v7|Stage IV Colorectal Cancer AJCC v7|Stage IVA Colorectal Cancer AJCC v7|Stage IVB Colorectal Cancer AJCC v7
Interventions: BIOLOGICAL: Panitumumab|DRUG: Oxaliplatin|DRUG: Leucovorin Calcium|DRUG: Fluorouracil|DRUG: Capecitabine|OTHER: Quality-of-Life Assessment|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Community-based Mental Health Care for People With Severe and Enduring Mental Ill Health (RECOVER-E) Croatia
Status: UNKNOWN
Conditions: Severe Mental Disorder|Schizophrenia|Bipolar Disorder|Severe Depression
Interventions: OTHER: Community mental health team
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety, Tolerability, PK and PD Study of AD-214 Administered to Healthy Volunteers and Patients With Interstitial Lung Disease or Chronic Kidney Disease
Status: COMPLETED
Conditions: Interstitial Lung Disease|Chronic Kidney Diseases
Interventions: BIOLOGICAL: AD-214|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Therapeutic Treatment With Human Monoclonal Antibody AR-105 (Aerucin®) in P. Aeruginosa Pneumonia
Status: COMPLETED
Conditions: Pseudomonas Aeruginosa Pneumonia
Interventions: DRUG: AR-105|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Anti-IL6R and Anticoagulation Therapy in Advanced NPC Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Tocilizumab Asprin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Optimising Treatments for Faecal Incontinence
Status: COMPLETED
Conditions: Faecal Incontinence|Pelvic Floor Disorders
Interventions: DEVICE: Renew VS PTNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Peri-operative Dexmedetomidine Infusion in Pre-eclamptic Patients
Status: COMPLETED
Conditions: Pre-Eclampsia
Interventions: DRUG: placebo infusion|DRUG: Dexmedetomidine infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Of Sunitinib In Combination With Capecitabine Compared With Capecitabine In Patients With Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Sunitinib + Capecitabine|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interscalene Block Versus Pericapsular Nerve Block and Superficial Cervical Plexus Block for Arthroscopic Shoulder Surgery
Status: NOT_YET_RECRUITING
Conditions: Interscalene Block|Superficial Cervical Block
Interventions: PROCEDURE: Interscalene brachial plexus block (ISB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Venous Thromboembolism and Bleeding Risk in Patients With Esophageal Cancer
Status: COMPLETED
Conditions: Venous Thromboembolism|Esophagus Cancer|Bleeding|Chemotherapy Effect
Interventions: OTHER: Venous thromboembolic event, arterial thromboembolic event, bleeding events
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Topical Versus Oral Metronidazole Following Excisional Haemorrhoidectomy
Status: COMPLETED
Conditions: Hemorrhoids|Postoperative Pain
Interventions: DRUG: Metronidazole Oral|DRUG: Metronidazole Ointment|DRUG: Placebo Oral Tablet|DRUG: Placebo Ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of an Early Rhythmic Intervention in Infancy
Status: ENROLLING_BY_INVITATION
Conditions: Language Development|Language Development Disorders|Infant Development|Intervention
Interventions: BEHAVIORAL: Rhythmic intervention|BEHAVIORAL: Passive auditory stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Structured Treatment of Osteoarthritis of the Knee With or Without Total Knee Replacement
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: OTHER: Neuromuscular training (NEMEX-TJR)|DRUG: Paracetamol|DRUG: Burana|DRUG: Pantoprazol|BEHAVIORAL: Dietary counseling|BEHAVIORAL: Patient education|PROCEDURE: TKR|OTHER: Insoles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Botulinum Toxin in Freezing of Gate in Parkinson's Disease Walking in Parkinson's Disease.
Status: NOT_YET_RECRUITING
Conditions: Freezing of Gate|Parkinson Disease|Botulinum Toxin
Interventions: DRUG: Botulinum toxin type A injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of MW032 and Xgeva® in Subjects With Bone Metastases From Solid Tumors
Status: COMPLETED
Conditions: Bone Metastases
Interventions: DRUG: MW032|DRUG: Xgeva
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Octreotide on Wound Drainage After Mastectomy
Status: COMPLETED
Conditions: Seroma Following Procedure
Interventions: DRUG: Octreotide Injection|OTHER: Sterile water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of the Q-HPV Vaccine 9-years Post Vaccination Among HIV Positive Adolescents
Status: COMPLETED
Conditions: HPV Infection|HPV Vaccination
Interventions: DRUG: Quadrivalent Human Papillomavirus (Types 6,11,16,18) Recombinant Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Three Month Safety and Efficacy Study of TRAVATAN® Versus Travoprost Ophthalmic Solution, 0.004%
Status: WITHDRAWN
Conditions: Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Travoprost Ophthalmic Solution, 0.004% (New Formulation)|DRUG: TRAVATAN®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Efficacy of an Electronic Discharge Communication Tool
Status: COMPLETED
Conditions: Other Diagnoses, Comorbidities, and Complications
Interventions: DEVICE: electronic discharge communication tool|DEVICE: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Studying the Effect of Denosumab on Preventing Breast Cancer in Women With a BRCA1 Germline Mutation
Status: RECRUITING
Conditions: BRCA1 Mutation|Breast Cancer|Breast Diseases|Breast Neoplasms|Breast Carcinoma|Neoplasms
Interventions: DRUG: Denosumab|DRUG: Placebo|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pivotal Bioequivalence FDC Nifedipine / Candesartan vs. Loose Combination of Single Components, Fed
Status: COMPLETED
Conditions: Hypertension, Essential
Interventions: DRUG: Nifedipine/Candesartan (BAY 98-7106)|DRUG: Nifedipine (Adalat, BAY A1040) and Candesartan (Atacand, BAY 12-9333)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Randomized, Multicenter Study of the Safety and Performance of Fabian PRICO for Saturation Targeting With Non-invasive Respiratory Support
Status: NOT_YET_RECRUITING
Conditions: Respiratory Insufficiency Syndrome of Newborn
Interventions: DEVICE: fabian Therapy evolution ventilators with PRICO (Predictive Intelligent Control of Oxygenation)|DEVICE: fabian Therapy evolution ventilators with manual FiO2 control
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Aliskiren in Post Myocardial Infarction Patients (ASPIRE)
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: Aliskiren|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Impact of Speed and Site of Subcutaneous Injection on Pain, Tolerability, Safety, and Pharmacokinetics of Gantenerumab in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Gantenerumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fixed Dose Combination Versus Free Combination of Tiotropium and Olodaterol in COPD
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: FDC of tiotropium + olodaterol|DRUG: Placebo|DRUG: Tiotropium|DRUG: Olodaterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Vitamin D3 Administration on Cardiac Autonomic Tone in Asthma Chronic Obstructive Pulmonary Disease(COPD) Overlap Patients
Status: COMPLETED
Conditions: Asthma-COPD Overlap Syndrome|Vitamin D Deficiency|Cardiac Autonomic Tone
Interventions: OTHER: Vitamin D capsule|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Clinical Effectiveness of a Collagen-ORC Antimicrobial Matrix in Venous Leg Ulcers
Status: COMPLETED
Conditions: Leg Ulcer
Interventions: DEVICE: Collagen ORC Antimicrobial Matrix (CAM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Pimecrolimus Cream 1% in Atopic Disease Modification
Status: TERMINATED
Conditions: Atopic Dermatitis
Interventions: DRUG: Pimecrolimus|DRUG: Corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PRETELL: PREvention of TELomere-related Complications After Lung Transplant
Status: WITHDRAWN
Conditions: Short Telomere Length|Lung Transplant
Interventions: DRUG: Danazol Pill|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Open-Label, Dose-Escalation With Expansion to Assess the Safety, Tolerability, and PK of TRE-515 in Subjects With Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor, Adult|Oncology
Interventions: DRUG: TRE-515
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Multi-Component Intervention on Suspected Asthma Population
Status: NOT_YET_RECRUITING
Conditions: Multimorbidity|Chronic Asthma|Population Medicine
Interventions: COMBINATION_PRODUCT: Multi-component Intervention Package
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pharmacokinetics of CVL-231 Following Single Oral Administration of Modified- and Immediate-release Formulations in Fasted and Fed Healthy Participants
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: 10 mg CVL-231 as IR formulation|DRUG: 30 mg CVL-231 as slow-release MR formulation|DRUG: 30 mg CVL-231 as medium release MR formulation|DRUG: 30 mg CVL-231 as fast release MR formulation|DRUG: 30 mg CVL-231 Target Release, Fasted|DRUG: 30 mg CVL-231 Target Release, Fed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peripheral Intravenous Central Catheter Intervention in Preterm Infants
Status: COMPLETED
Conditions: Preterm|Pain, Acute|Stress|Nursing Caries
Interventions: BEHAVIORAL: Graspin Palmar Reflex Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SA4503 8-Week Study in Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: placebo|DRUG: SA4503 Low|DRUG: SA4503 High
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Furosemide and Creatinine Tubular Stress Test in Order to Measure Proximal Tubule Residual Function
Status: UNKNOWN
Conditions: Chronic Kidney Failure
Interventions: DRUG: Furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of Exenatide (Byetta ) on Energy Expenditure and Weight Loss in Nondiabetic Obese Subjects
Status: COMPLETED
Conditions: Weight Loss|Obesity
Interventions: DRUG: Byetta (exenatide)|BEHAVIORAL: Weight loss|OTHER: Metabolic Chamber|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Clevidipine Butyrate Injection in Hypertensive Emergencies
Status: UNKNOWN
Conditions: Hypertensive Emergency
Interventions: DRUG: Clevidipine Butyrate Injection|DRUG: Ncardipine Hydrochloride Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vibrotactile Coordinated Reset for Spasticity After Spinal Cord Injury
Status: NOT_YET_RECRUITING
Conditions: Spasticity, Muscle|Spinal Cord Injuries
Interventions: DEVICE: Vibrotactile Coordinated Reset
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Extension of a Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Lovaza® and Simvastatin Therapy in Hypertriglyceridemic Subjects
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DRUG: Simvastatin + Lovaza® (omega-3-acid ethyl esters)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of Topical NS2 Cream to Treat Ichthyosis in Sjögren-Larsson Syndrome (SLS)
Status: COMPLETED
Conditions: Sjögren-Larsson Syndrome
Interventions: DRUG: Active topical NS2 1% dermatologic cream|DRUG: Vehicle placebo 0.0% NS2 dermatologic cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Two Different Formulations of an HIV Vaccine in Infants Born to HIV-Infected Women
Status: WITHDRAWN
Conditions: HIV Infections|HIV Seronegativity
Interventions: BIOLOGICAL: Aluminum hydroxide|BIOLOGICAL: QS-21|BIOLOGICAL: MN rsgp120/HIV-1
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: A Study of the Safety and Effectiveness of an HIV Vaccine for HIV-Positive Patients Receiving Anti-HIV Drugs for at Least 2 Years
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: ALVAC(2)120(B,MN)GNP (vCP1452)|BIOLOGICAL: gp160 MN/LAI-2
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Assess the Efficacy and Safety of EASYDEW MD REGEN Cream Containing Neopop-S.
Status: COMPLETED
Conditions: Laser-Induced Scar
Interventions: DEVICE: EasyDew Regen MD Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Minimally Invasive Mitral Valve Replacement Versus Conventional Approach: Comparison of Early Postoperative Outcomes.
Status: UNKNOWN
Conditions: Minimally Invasive Mitral Valve Surgery
Interventions: PROCEDURE: mitral valve replacement through full sternotomy approach.|PROCEDURE: mitral valve replacement through right mini thoracotomy approach.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Clinical Trial to Assess Safety and Tolerability in Subjects With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Reproxalap Ophthalmic Solution (0.25%)|DRUG: Xiidra® (5% lifitegrast ophthalmic solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation Of The Effect Of Surface Properties On The Stabılıty Of The Different Implants
Status: COMPLETED
Conditions: Dental Implantation
Interventions: DEVICE: Evaluation of the effect of surface properties on the stability of the different implants with resonance frequency analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: LV Thrombus Pilot Study for Comparing Enoxaparin Vs. Warfarin
Status: COMPLETED
Conditions: Coronary Artery Disease|Acute Myocardial Infarction
Interventions: DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Accessible Cancer Care to Enable Support for Survivors Programme
Status: UNKNOWN
Conditions: Survivorship|Breast Cancer|Gynecologic Cancer
Interventions: OTHER: Supportive and survivorship care program|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission
Status: COMPLETED
Conditions: B-cell Childhood Acute Lymphoblastic Leukemia|Childhood Acute Lymphoblastic Leukemia in Remission|Graft Versus Host Disease|L1 Childhood Acute Lymphoblastic Leukemia|L2 Childhood Acute Lymphoblastic Leukemia|T-cell Childhood Acute Lymphoblastic Leukemia
Interventions: DRUG: thiotepa|DRUG: cyclophosphamide|DRUG: tacrolimus|DRUG: methotrexate|DRUG: sirolimus|RADIATION: total body irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Small Bowel Lesions Associated With Celecoxib Versus Ibuprofen Plus Omeprazole
Status: COMPLETED
Conditions: Bowel Diseases, Inflammatory
Interventions: DRUG: Celecoxib|OTHER: Placebo|DRUG: Ibuprofen plus Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pro-permeability and Pro-fibrosis Factors in the Aqueous of Patients With Retinal Diseases
Status: TERMINATED
Conditions: Macular Edema|Fibrosis of the Retina
Interventions: DRUG: Ozurdex|PROCEDURE: Surgery|PROCEDURE: Anterior Chamber (AC) Tap
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sit-to-Stand Training for Survivors of Stroke in a Long-Term Care Setting
Status: UNKNOWN
Conditions: Cerebrovascular Accident
Interventions: BEHAVIORAL: Sit-To-Stand Protocol and Extra Practice in Sit-To-Stand
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of 5-Methyltetrahydrofolate and Vitamin B12 Supplemetation on Red Cell Membrane in Children With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DIETARY_SUPPLEMENT: 5-methyltetrahydrofolate and vitamin B12
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Post-resection/Ablation Chemotherapy in Patients With Metastatic Colorectal Cancer (FIRE-9 - PORT / AIO-KRK-0418)
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: mFOLFOX6|DRUG: mFOLFOXIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Web-based Approach to Treating Cardiovascular Disease Risk in Employees With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome|Cardiovascular Disease|Atherosclerosis|Obesity
Interventions: BEHAVIORAL: My Everyday Health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determination of Optimal Positive End-expiratory Pressure Using Electrical Impedance Tomography in Children Under General Anesthesia: Comparison Between Supine and Prone Positions
Status: COMPLETED
Conditions: General Anesthesia
Interventions: OTHER: Exploration of optimal PEEP in supine and prone position
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immediate Implant Outcomes With and Without Bone Augmentation
Status: ENROLLING_BY_INVITATION
Conditions: Tooth Loss|Bone Loss, Alveolar|Dental Diseases|Dental Trauma
Interventions: PROCEDURE: implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Yiqi Wenyang Jiedu Prescription in the Prevention and Treatment of Postoperative Metastasis and Recurrence of Gastric Cancer
Status: RECRUITING
Conditions: Gastric Carcinoma
Interventions: DRUG: Yiqi Wenyang Jiedu prescription|DRUG: Simulation agent of Yiqi Wenyang Jiedu prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment Of Peri-papillary Retinal Nerve Fiber Layer Thickness In Patients With Unilateral Branch Retinal Vein Occlusion
Status: COMPLETED
Conditions: Branch Retinal Vein Occlusion
Interventions: DRUG: aflibercept (2mg/0.05ml)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Distribution of Pulmonary Ventilation in Lateral Decubitus of Healthy Adults Under Non-Invasive Mechanical Ventilation
Status: COMPLETED
Conditions: Noninvasive Ventilation|Patient Positioning
Interventions: DEVICE: Positive End Expiratory Pressure 5 H2O|DEVICE: Positive End Expiratory Pressure 10 H2O
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Vitamin D Supplementation on Cardiometabolic Risk Factors [The Daily D Health Study]
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Placenta Derived Stem Cells for Treating of Chronic Ulcers and Neuropathy
Status: COMPLETED
Conditions: Diabetic Foot|Diabetic Neuropathies|Diabetic Foot Ulcer
Interventions: BIOLOGICAL: Transplantation of Placenta Derived Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Efficacy On Vascular Permeability In Patients With Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: ZD6474 (Zactima) 100mg|PROCEDURE: Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MR)|PROCEDURE: Biomarker Draws|DRUG: ZD6474 (Zactima) 300mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ECLECTIC: EstroTEP and Circulating Biomarkers for ER-positive HER2-negative Metastatic Breast Cancer Patients
Status: RECRUITING
Conditions: Breast Carcinoma
Interventions: COMBINATION_PRODUCT: Endocrine therapy|COMBINATION_PRODUCT: Endocrine therapy combined with the local treatment of FES-negative lesions|COMBINATION_PRODUCT: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: Hydrocortisone|DRUG: Sterile air filled vial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is the Short Physical Performance Battery a Useful Outcome Measure in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|Lung Diseases, Obstructive|Pulmonary Emphysema|Bronchitis, Chronic|Lung Diseases|Disease Progression
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Atazanavir/Ritonavir Monotherapy as Maintenance in Patients With Viral Suppression
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Atazanavir/ritonavir monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Walking Exercise Based on TOUS on Peripheral Neuropathy and Arthralgia-Myalgia in Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Peripheral Neuropathies|Arthralgia|Myalgia
Interventions: BEHAVIORAL: walking exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: RIC Regimen for Elderly or High Comorbidity Burden Patients Receiving Haplo-HSCT
Status: RECRUITING
Conditions: Acute Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lifestyle and Brain Vascular Function
Status: TERMINATED
Conditions: Healthy Lifestyle|Physical Exercise|Healthy Diet|Cerebrovascular Circulation|Cerebral Blood Flow|Glucose Metabolism|Cognitive Performance
Interventions: OTHER: Healthy Lifestyle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Operator and Patient Acceptance of Radiofrequency Cautery of the Biopsy Track During Percutaneous Liver, Kidney or Spleen Biopsy Procedures.
Status: TERMINATED
Conditions: Bleeding Disorder|Spleen Lesion|Liver Diseases|Kidney Diseases
Interventions: DEVICE: RF track cautery during percutaneous organ biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Cool Spray and Cold Packs in Reducing Preoperative Edema and Pain in Ankle Fractures in Ubonratchathani
Status: ACTIVE_NOT_RECRUITING
Conditions: Ankle Fractures|Swelling|Cryotherapy Effect
Interventions: DEVICE: 3M cold pack|DEVICE: Perskindol cold spray|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compliance of Compression Therapy in Healed Venous Ulcerations
Status: WITHDRAWN
Conditions: Venous Insufficiency
Interventions: DEVICE: Compression stocking 15-20mmHg|DEVICE: Compression stocking 20-30mmHg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Validation of a Semi-automatized Method to Detect Cyclic Hyperinflation on CT-scan in ARDS
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome (ARDS)
Interventions: OTHER: ARDS patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Acupuncture Treatment for Schizophrenia-related Central Obesity
Status: RECRUITING
Conditions: Schizophrenia|Central Obesity
Interventions: DEVICE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ADCs Combined With Adebrelimab in HER2-negative Advanced Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Advanced Breast Cancer
Interventions: DRUG: SHR-A1811|DRUG: SHR-A1921|DRUG: Adebrelimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Efficacy, Safety and Tolerability of JTT-861 in Subjects With Heart Failure With Reduced Ejection Fraction
Status: RECRUITING
Conditions: Chronic Heart Failure
Interventions: DRUG: JTT-861 Capsules|DRUG: Placebo Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial of Imagery Rescripting Treatment In Veterans With Trauma-Related Nightmares And Posttraumatic Stress Disorder (PTSD)
Status: TERMINATED
Conditions: Stress Disorders, Post-Traumatic|Sleep Disorders
Interventions: BEHAVIORAL: Veteran Nightmare Treatment|BEHAVIORAL: Treatment-as-usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-dose Nifedipine-Valsartan Combination Compared to Up-titrated Valsartan Monotherapy in Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Adalat (Nifedipine, BAYA1040)|DRUG: Diovan (Valsartan)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Status and Quality of Life in Older Patients Undergoing Robotic Surgery for Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Surgery|Geriatric Assessment|Quality of Life
Interventions: DIAGNOSTIC_TEST: Geriatric Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Efficacy and Safety of Oral OPS-2071 in Participants With Crohn's Disease Showing Symptoms of Active Inflammation
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: DRUG: OPS-2071|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1|Endothelial Dysfunction
Interventions: DRUG: Dulaglutide|DRUG: Placebo|BEHAVIORAL: exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of the Type of Interface in Neuromuscular Patients Treated With Nocturnal Noninvasive Ventilation
Status: COMPLETED
Conditions: Neuromuscular Diseases|Alveolar Hypoventilation
Interventions: DEVICE: Switch of nocturnal NIV interface
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Surgical Treatment of Spinal Deformity With Sagittal Imbalance Using Patient-specific Rods: A Multicenter, Controlled, Double- Blind Randomized Trial: The PROFILE Study
Status: COMPLETED
Conditions: Spinal Deformity With Sagittal Imbalance
Interventions: DEVICE: Surgery with patient-specific rod|DEVICE: Conventional straight rod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Oxygen Supply After Lung Isolation in Thoracic Surgery
Status: COMPLETED
Conditions: Mechanical Ventilation|Thoracic Surgery|One-Lung Ventilation
Interventions: DRUG: restrictive oxygen supply|DRUG: liberal oxygen supply
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Esophageal Echo Assessment of LV Function During Acute Normovolemic Hemodilution Using Crystalloid or Hypertonic Saline
Status: COMPLETED
Conditions: Acute Hypovolemia
Interventions: OTHER: Volume resuscitation (Crystalloid)|OTHER: Volume resuscitation (Hypertonic Saline Solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zanubrutinib Combined With Rituximab and Chemotherapy for Newly-Diagnosed PCNSLBCL Patients Intolerant to HSCT
Status: RECRUITING
Conditions: PCNSL
Interventions: DRUG: Zanubrutinib|DRUG: Rituximab|DRUG: Methotrexate|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chewing Gum and Gastric Emptying of Water
Status: COMPLETED
Conditions: Comparison of Gastric Emptying Rate of Water When Chewing Gum or Not
Interventions: BEHAVIORAL: 1 chewing gum over 45 minutes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sub-maximal Exercise Prescription in Adolescents With Physiological Post-concussion Disorder
Status: UNKNOWN
Conditions: Physiological Post-Concussion Disorder|Post-Concussion Syndrome|Traumatic Brain Injury|Rehabilitation|Aerobic Exercise|Concussion, Brain
Interventions: BEHAVIORAL: Sub-symptom aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SkIN hydrAtion Evaluation With TeRAhertz Scanning
Status: COMPLETED
Conditions: Cancer|Skin Cancer|Dry Skin; Eczema|Medical Device Site Eczema
Interventions: DEVICE: Terahertz scanning
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Continuous Defocused CO2 Laser Vaporisation on the Histological Malignant Transformation of Erosive Oral Lichen Planus in Patients
Status: COMPLETED
Conditions: Oral Lichen Planus
Interventions: DEVICE: CO2-Laser Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate Safety and Efficacy of TJ107 Combine With PD-1 in Patients With Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple-negative Breast Cancer|Head and Neck Squamous Cell Carcinoma
Interventions: BIOLOGICAL: TJ107 +Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cytochrome P450-2D6 Screening Among Elderly Using Antidepressants (CYSCE)
Status: COMPLETED
Conditions: Depression|Depressive Disorder|Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant|Intermediate Metabolizer Due to Cytochrome P450 CYP2D6 Variant|Ultrarapid Metabolizer Due to Cytochrome P450 CYP2D6 Variant
Interventions: OTHER: Genotype information accompanied by a drug dosing advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: KHK2455 Alone and in Combination With Mogamulizumab in Subjects With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor|Cancer|Carcinoma
Interventions: DRUG: KHK2455|DRUG: Mogamulizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Investigate Long-term Safety, Tolerability, and Efficacy of Weekly Subcutaneous Doses With TransCon CNP in Children and Adolescents With Achondroplasia
Status: ENROLLING_BY_INVITATION
Conditions: Achondroplasia
Interventions: DRUG: TransCon CNP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Pharmacokinetics of Hypidone Hydrochloride in Healthy Subjects
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Hypidone Hydrochloride tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Men With Benign Prostatic Hyperplasia
Status: TERMINATED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: LY500307|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Pilot Study of the OP-1 Putty in Uninstrumented Posterolateral Fusions
Status: COMPLETED
Conditions: Degenerative Lumbar Spondylolisthesis
Interventions: DEVICE: Use of OP-1 Putty in Uninstrumented posterolateral fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Followed by Donor Bone Marrow Transplant or Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer or Genetic Disorders
Status: UNKNOWN
Conditions: Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: anti-thymocyte globulin|DRUG: cyclosporine|DRUG: fludarabine phosphate|DRUG: melphalan|DRUG: methylprednisolone|DRUG: mycophenolate mofetil|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation|PROCEDURE: syngeneic bone marrow transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Diagnostic Potential of BAY1006578 in Probable Alzheimers Disease Patients Versus Healthy Volunteers and Radiation Dosimetry of BAY1006578 in Healthy Volunteers
Status: COMPLETED
Conditions: Diagnostic Imaging
Interventions: DRUG: BAY1006578|DRUG: BAY1006578|DRUG: BAY1006578
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of the Safety and Efficacy of Risankizumab in Adult Participants With Plaque Psoriasis Who Have Had a Suboptimal Response to Secukinumab or Ixekizumab
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Risankizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Assessing Perfusion Outcomes With PINPOINT® Near Infrared Fluorescence Imaging in Low Anterior Resection
Status: TERMINATED
Conditions: Rectal Cancer|Rectosigmoid Cancer
Interventions: DEVICE: PINPOINT|DEVICE: SPY Elite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor Atorvastatin Treatment for Preventing Severe Acute Graft-Versus-Host Disease in Patients Undergoing Myeloablative Peripheral Blood Stem Cell Transplantation
Status: COMPLETED
Conditions: Malignant Neoplasm
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Atorvastatin Calcium|PROCEDURE: Peripheral Blood Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of OZURDEX® in Patients With Macular Edema Secondary to Retinal Vein Occlusion in China
Status: COMPLETED
Conditions: Macular Edema|Retinal Vein Occlusion
Interventions: DRUG: OZURDEX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU
Status: COMPLETED
Conditions: Laryngeal Edema
Interventions: DIAGNOSTIC_TEST: Cuff Leak Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Osimertinib Plus Bevacizumab in Untreated EGFR Exon21 L858R Mutated NSCLC
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer
Interventions: DRUG: Osimertinib|DRUG: Bevacizumab|DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Omega-3 Fatty Acid Paediatric Depression Trial
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Omega 3 fatty acid|DRUG: Placebo oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT