pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Barbed Suture and Triclosan-coated Monofilament in Emergency Surgery
Status: COMPLETED
Conditions: Surgical Site Infection
Interventions: COMBINATION_PRODUCT: Triclosan-coated barbed suture|COMBINATION_PRODUCT: Triclosan-coated monofilament suture|DEVICE: Monofilament suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Probiotics for the Prevention of Gastrointestinal Toxicity in Children With Leukemia
Status: NOT_YET_RECRUITING
Conditions: Probiotics|Gastrointestinal Diseases|Precursor Cell Lymphoblastic Leukemia-Lymphoma
Interventions: BIOLOGICAL: Lactobacillus casei|BIOLOGICAL: Lactobacillus rhamnosus|BIOLOGICAL: Bifidobacterium bifidum|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Century Trial, a Randomized Lifestyle Modification Study for Management of Stable Coronary Artery Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Disease|Atherosclerosis|Coronary Artery Disease|Coronary Stenosis
Interventions: OTHER: Comprehensive therapy program for risk factor modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Medulloblastoma
Interventions: DRUG: Cisplatin|DRUG: Cyclophosphamide|OTHER: Laboratory Biomarker Analysis|DRUG: Lomustine|PROCEDURE: Magnetic Resonance Imaging|RADIATION: Radiation Therapy|DRUG: Vincristine|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRECISION Study: Multi-center Study of Performance of a Novel Implanted CGM System Using a Next Generation Transmitter and Algorithm
Status: COMPLETED
Conditions: Diabetes Mellitus|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DEVICE: Continuous glucose monitoring system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: HIIT in Pediatric Heart Transplant Recipients (MedBIKE™)
Status: RECRUITING
Conditions: Pediatric ALL|Transplant; Failure, Heart
Interventions: DEVICE: MedBIKE HIIT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Clinical Effectiveness and Safety of a Novel Oral Rehydration Solution
Status: COMPLETED
Conditions: Gastroenteritis Acute
Interventions: DIETARY_SUPPLEMENT: Glucose containing Oral Rehydration Solution (ORS)|DIETARY_SUPPLEMENT: Sugar free - amino acid and electrolyte ORS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treating Hepatitis C in CRF Using Sofosbuvir and Daclatasvir
Status: COMPLETED
Conditions: Hepatitis C, Chronic|Chronic Renal Failure
Interventions: DRUG: Sofosbuvir 400 mg and daclatasvir 60 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vandetanib-eluting Radiopaque Embolic Beads in Patients With Resectable Liver Malignancies
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular|Metastatic Colorectal Cancer
Interventions: DRUG: BTG-002814
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Escalation Study of SCD-101 in Sickle Cell Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Sickle Cell Disease|Sickle-Beta Zero Thalassemia
Interventions: DRUG: SCD-101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention, Efficacy and Safety of BCG Vaccine in COVID-19 Among Healthcare Workers
Status: UNKNOWN
Conditions: BCG|COVID-19|SARS-CoV2|Corona Virus Infection
Interventions: BIOLOGICAL: BCG vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Dupilumab for the Treatment of Patients With Prurigo Nodularis, Inadequately Controlled on Topical Prescription Therapies or When Those Therapies Are Not Advisable (PRIME2)
Status: COMPLETED
Conditions: Neurodermatitis
Interventions: DRUG: Dupilumab SAR231893|DRUG: Placebo|DRUG: Moisturizers|DRUG: Low to medium potent topical corticosteroids|DRUG: Topical calcineurin inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ablation and Left Atrium Reduction During Mitral Valve Surgery for Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: maze procedure|PROCEDURE: mitral valve surgery|PROCEDURE: left atrial reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: 'M'-Technique, Guided Imagery, or Standard of Care on Anxiety and Pain Pre- & Post-operatively in Elective Joint Replacement Patients
Status: UNKNOWN
Conditions: Hip or Knee Replacement
Interventions: OTHER: 'M'-Technique®|OTHER: Guided Imagery|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: tDCS of the Primary Motor Cortex to Improve Implicit Motor Sequence Learning in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease|Parkinson|Healthy
Interventions: DEVICE: 1x1 Low Intensity Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Fixed-Dose Combination Tablet of Bemnifosbuvir and Ruzasvir
Status: RECRUITING
Conditions: Healthy Volunteer Study
Interventions: DRUG: Bemnifosbuvir (BEM)/Ruzasvir (RZR) FDC under fasting conditions|DRUG: Bemnifosbuvir (BEM)/Ruzasvir (RZR) FDC under fed conditions|DRUG: Bemnifosbuvir (BEM) and Ruzasvir (RZR) as reference formulation under fasting conditions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cinacalcet Hydrochloride in Treating Men With Recurrent Prostate Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate|Recurrent Prostate Cancer
Interventions: OTHER: laboratory biomarker analysis|PROCEDURE: quality-of-life assessment|OTHER: questionnaire administration|DRUG: cinacalcet hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Microplasmin in Patients Undergoing Surgical Vitrectomy
Status: COMPLETED
Conditions: Vitreomacular Traction Maculopathy|Eye Diseases
Interventions: DRUG: Microplasmin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 12-week Safety and Efficacy Study of Beclomethasone Dipropionate (80 and 160 mcg/Day) Delivered Via Breath-Actuated Inhaler (BAI) in Patients >=12 Years Old With Persistent Asthma
Status: COMPLETED
Conditions: Persistent Asthma
Interventions: DRUG: Beclomethasone dipropionate breath-actuated inhaler|DRUG: Placebo breath-actuated inhaler|DRUG: albuterol/salbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Aromatherapy on Postoperative Nausea, Vomiting
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: PROCEDURE: Lavender Aromatherapy|PROCEDURE: Rose Aromatherapy|PROCEDURE: Ginger Aromatherapy|PROCEDURE: Placebo Aromatherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Graves' Disease Remission Study: MycoMeth Combo
Status: RECRUITING
Conditions: Graves' Disease
Interventions: DRUG: Mycophenolate Mofetil, Oral, 250 Mg|DRUG: methimazole, oral, 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Different Dosages of High-Dose Quadrivalent Influenza Vaccine in Children 6 Months to 17 Years of Age
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: High-Dose Quadrivalent Influenza Vaccine (QIV-HD) 30 μg (split-virion, inactivated)|BIOLOGICAL: High-Dose Quadrivalent Influenza Vaccine (QIV-HD) 45 μg, (split-virion, inactivated)|BIOLOGICAL: High-Dose Quadrivalent Influenza Vaccine (QIV-HD) 60 µg (split-virion, inactivated)|BIOLOGICAL: Fluarix Quadrivalent Influenza vaccine (Unadjuvanted QIV-SD) (Inactivated)|BIOLOGICAL: FLUAD Pediatric (adjuvanted TIV) (Surface Antigen, Inactivated)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cognitive Stimulation in Daily Activities for People Living With Early to Middle Stage Dementia
Status: COMPLETED
Conditions: Dementia|Dementia, Mild|Dementia Moderate
Interventions: BEHAVIORAL: CS-ADL (Cognitive stimulation in Activities of Daily Living)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Endotracheal Tube With Polyurethane Cuff and Subglottic Secretion Drainage
Status: COMPLETED
Conditions: Mechanical Ventilation
Interventions: PROCEDURE: tube with subglottic drainage and polyurethane cuff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Observational Study to Evaluate the Efficacy and Safety of NovoMix® 30 in Type 1 and 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart 30
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Blood Transplantation for Patients With Hematologic Malignancies or Bone Marrow Failure States
Status: TERMINATED
Conditions: Leukemia|Non Hodgkin's Lymphoma|Aplastic Anemia
Interventions: PROCEDURE: Megadose T-cell Depleted HLA-nonidentical Blood Progenitor Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Effects of Peginterferon Alfa-2a Plus Ribavirin for Chronic Hepatitis C/B Co-Infection and Chronic Hepatitis C
Status: COMPLETED
Conditions: Coinfection With Hepatitis B Virus and Hepatitis C Virus|Monoinfection With Hepatitis C Virus
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilates Exercises on Muscle Strength and Balance After Healed Lower Limb Burns
Status: COMPLETED
Conditions: Lower Limb Burns
Interventions: OTHER: Pilates exercises|OTHER: Traditional physical therapy programme:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dabrafenib/Trametinib/Hydroxychloroquine for Advanced Pretreated BRAF V600 Mutant Melanoma
Status: UNKNOWN
Conditions: Melanoma
Interventions: DRUG: Dabrafenib|DRUG: Trametinib|DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study to Evaluate the Clinical and Cost Effectiveness of a Youth Culturally Adapted Therapy (YCMAP)
Status: COMPLETED
Conditions: Self Harm
Interventions: BEHAVIORAL: Youth Culturally Adapted Manual Assisted Psychological Therapy (Y-CMAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Midurethral Synthetic Tape With Tension Control Mechanism Versus Midurethral Free Tape
Status: UNKNOWN
Conditions: Urinary Stress Incontinence
Interventions: PROCEDURE: surgical management of stress urinary incontinence with midurethral tension free tape.|PROCEDURE: surgical management of stress urinary incontinence with synthetic tape with tension control mechanism.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Two Different Doses of Cabozantinib (XL184) in Progressive, Metastatic Medullary Thyroid Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Medullary Thyroid Cancer
Interventions: DRUG: Cabozantinib (XL184) 140 mg|DRUG: Cabozantinib (XL184) 60 mg|DRUG: Placebo tablet|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: How TKA Implants Affect Muscle Quality and Activity During Daily Living and Immunological Response
Status: UNKNOWN
Conditions: Osteoarthritis, Knee|Inflammation Knees
Interventions: DEVICE: Zimmer NexGen LPS-Flex|DEVICE: Smith & Nephew Journey II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Left Bundle Branch Area Pacing in Patients After TAVR
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Valve Stenosis|AV Block|Pacing-Induced Cardiomyopathy
Interventions: DEVICE: Left bundle branch area pacing|DEVICE: Right ventricular pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real Life Evaluation of the Multi-organ Effects of Lumacaftor/Ivacaftor on F508del Homozygous Cystic Fibrosis Patients.
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Lumacaftor, Ivacaftor Drug Combination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Personalized Warfarin Dosing by Genomics and Computational Intelligence
Status: TERMINATED
Conditions: Venous Thrombosis|Atrial Fibrillation|Myocardial Infarction
Interventions: DEVICE: Genomics
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Blue Sky Study: Impact of Milk and Vitamin D for Child Growth and Health
Status: COMPLETED
Conditions: Vitamin d Deficiency
Interventions: DIETARY_SUPPLEMENT: Mongolian milk without vitamin D|DIETARY_SUPPLEMENT: Mongolian milk with vitamin D|DIETARY_SUPPLEMENT: UHT milk|DIETARY_SUPPLEMENT: Milk Substitute|DIETARY_SUPPLEMENT: Seasonal D supplement|DIETARY_SUPPLEMENT: Daily D supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypobetalipoproteinemia
Interventions: GENETIC: hypobetalipoproteinemia genetic and genotypic screening
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: LCAR-M61S and LCAR-M61D in Treatment of Relapsed/Refractory Multiple Myeloma
Status: NOT_YET_RECRUITING
Conditions: Relapsed/Refractory Multiple Myeloma
Interventions: BIOLOGICAL: LCAR-M61S cells preparation|BIOLOGICAL: LCAR-M61D cells preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes of Breast Conservative Surgery for Post Chemotherapy Tumour Size After Response to Neoadjuvant Chemotherapy
Status: RECRUITING
Conditions: Safety of Excision the New Tumor Size
Interventions: PROCEDURE: breast conservative surgery for post chemotherapy tumour size
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yogic Breathing and Guided Meditation for Long Covid Symptoms
Status: COMPLETED
Conditions: COVID-19|Stress|Shortness of Breath
Interventions: BEHAVIORAL: Breathing and Wellness Webinar|OTHER: Routine Daily Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diabetes/ Endocrine Surveillance in SDS
Status: TERMINATED
Conditions: Shwachman-Diamond Syndrome
Interventions: DIAGNOSTIC_TEST: Oral Glucose Tolerance Test|OTHER: Modified Oral Glucose Tolerance Test|OTHER: Modified Mixed Meal Tolerance Test|DEVICE: Continuous Glucose Monitor|OTHER: Food Diary|OTHER: Medical History Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized Controlled Phase II Trial of STIMULAN VG vs Standard of Care (SoC) for the Treatment of Osteomyelitis Associated With Stage IV Pressure Ulcers.
Status: NOT_YET_RECRUITING
Conditions: Pressure Ulcer, Stage IV|Osteomyelitis
Interventions: COMBINATION_PRODUCT: STIMULAN VG|PROCEDURE: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate Bioequivalence of LCB01-0371 in Different Batches
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LCB01-0371 tablet 400mg (Test drug, Batch# 3183817R)|DRUG: LCB01-0371 tablet 400mg (Reference drug, Batch# 1650006)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Nutritional Status on Oncologic and Operative Outcome in Patients Operated for Retroperitoneal Sarcoma
Status: RECRUITING
Conditions: Retroperitoneal Sarcoma|Body Composition|Malnutrition|Sarcopenia|Sarcopenic Obesity|Myosteatosis
Interventions: OTHER: Measurement of body composition with computed tomography (CT)|DIAGNOSTIC_TEST: GLIM malnutrition criteria|DIAGNOSTIC_TEST: EWGSOP2 sarcopenia criteria|DIAGNOSTIC_TEST: ESPEN-EASO criteria for sarcopenic obesity|DIAGNOSTIC_TEST: Prognostic Nutritional Index (PNI)|DIAGNOSTIC_TEST: The high-sensitivity modified Glasgow prognostic score
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Analgesic Efficacy, Safety and Tolerability of Two Paracetamol-containing Solutions in Post-Surgical Dental Pain
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Paracetamol (acetaminophen) solution experimental|DRUG: paracetamol (acetaminophen) solution commercial|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Discovery and Validation of Genetic Variants Affecting Microglial Activation in Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: 11C-ER176|DRUG: 18F-florbetaben
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: SANICS II Trial: Stimulation of the Autonomic Nervous System in Colorectal Surgery by Perioperative Nutrition
Status: COMPLETED
Conditions: Postoperative Ileus|Anastomotic Leak
Interventions: DIETARY_SUPPLEMENT: enriched enteral nutrition|DIETARY_SUPPLEMENT: standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Fractionated 90Y Ibritumomab Tiuxetan (Zevalin) Radioimmunotherapy as an Initial Therapy of Follicular Lymphoma
Status: COMPLETED
Conditions: Follicular Lymphoma
Interventions: DRUG: 90Y Ibritumomab tiuxetan|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Irrigation of the Extraction Socket With Rifamycine
Status: ACTIVE_NOT_RECRUITING
Conditions: Impacted Third Molar Tooth
Interventions: DRUG: Rifamycine|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SRK-181 Alone or in Combination With Anti-PD-(L)1 Antibody Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (DRAGON)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer
Interventions: BIOLOGICAL: SRK-181|BIOLOGICAL: anti-PD-(L)1 antibody therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eszopiclone and Inflammatory Mediators in Patients With Acute Coronary Syndrome
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Sleep Disorder
Interventions: DRUG: Eszopiclone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Tolerability Study of SHP626 in Overweight and Obese Adults
Status: COMPLETED
Conditions: Non-Alcoholic Steatohepatitis
Interventions: DRUG: SHP626|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Early Antibiotics on Non-Traumatic Out of Hospital Cardiac Arrest (OHCA)
Status: RECRUITING
Conditions: Infection, Bacterial|Out-Of-Hospital Cardiac Arrest
Interventions: OTHER: No use of antibiotics|OTHER: with antibiotics treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The HARMONY Study: A Intervention to Reduce Cardiometabolic Risk in African American Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Diseases|Stroke|Pre-diabetes|Hypertension|Obesity|Overweight|Stress
Interventions: BEHAVIORAL: HARMONY|BEHAVIORAL: Nutrition and Exercise Education (NEEW)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Feasibility and Efficacy of a Combination of a SEMS and Vacuum Wound Treatment (VACStent)
Status: UNKNOWN
Conditions: Perforation Esophagus|Esophageal Cancer|Esophageal Achalasia|Esophageal Diseases
Interventions: DEVICE: VACStent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VNRX-7145 Drug-Drug Interaction in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: VNRX-7145|DRUG: VNRX-5024 (ceftibuten)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study in Parkinson's Disease in Patients With Moderate to Severe Dyskinesia
Status: COMPLETED
Conditions: Dyskinesias
Interventions: DRUG: JM-010 group A|DRUG: JM-010 group B|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Upper Limb Ergometer on Pulmonary Function Among Patients With Spinal Cord Injury.
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: OTHER: Conventional Treatment|OTHER: Upper Limb ergometer training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Scintigraphic Comparison of Lung Deposition With Two Nebulizers During Invasive Mechanical Ventilation
Status: TERMINATED
Conditions: Post-operative Neurosurgery
Interventions: DRUG: technetium-99m - Diethylenetriaminepentaacetic acid|DEVICE: Vibrating-mesh nebulizer|DEVICE: Jet Nebulizer|OTHER: Planar scintigraphy|OTHER: Preoperative spirometry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Rehabilitation in Patients With Chronic Fibrotic Hypersensitivity Pneumonitis
Status: UNKNOWN
Conditions: Hypersensitivity Pneumonitis|Extrinsic Allergic Alveolitis
Interventions: OTHER: Pulmonary Rehabilitation|OTHER: Alternative Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Changes in Arch Parameters After Molar Distalization; Hybrid Hyrax Distalizer Versus Pendulum
Status: ENROLLING_BY_INVITATION
Conditions: Angle Class 2 Malocclusion
Interventions: DEVICE: Hybrid hyrax distalizer|DEVICE: Pendulum distalizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Obstructive Sleep Apnea Treatment on Dizziness, Vertigo
Status: WITHDRAWN
Conditions: Sleep Apnea|Dizziness|Vertigo
Interventions: OTHER: Treatment of Obstructive Sleep Apnea-CPAP/BiPAP etc./Diet/surgery/life style changes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 2B Multicenter, Randomized, Comparative Trial Of UK-453,061 Versus Etravirine In Combination With Darunavir/Ritonavir And A Nucleos(t)Ide Reverse Transcriptase Inhibitor For The Treatment Of Antiretroviral Experienced HIV-1 Infected Subjects With Evidence Of NNRTI Resistant HIV-1
Status: TERMINATED
Conditions: HIV-1
Interventions: DRUG: UK-453,061 Dose 1|DRUG: UK-453,061 Dose 2|DRUG: Etravirine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Influenza Immunization of Children in India
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Inactivated Trivalent Influenza Vaccine (TIV)|BIOLOGICAL: Inactivated poliovirus vaccine (IPV), trivalent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Routine Feedback to Clinicians on Youth Mental Health Outcomes: A Randomized Cluster Design
Status: COMPLETED
Conditions: Mental Health Wellness 1|Psychosocial Problem
Interventions: BEHAVIORAL: Contextualized Feedback Systems (CFS)tm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A 12 Week, Multicenter, Open Label Evaluation of Caregiver Preference, Safety and Tolerability of Exelon® Patch (Rivastigmine Transdermal) in Patients With Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Rivastigmine transdermal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Trial of Cryotherapy Versus Postoperative Laser Photocoagulation
Status: COMPLETED
Conditions: Rhegmatogenous Retinal Detachment
Interventions: PROCEDURE: criopexy|PROCEDURE: laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dobutamine Versus Placebo for Low Superior Vena Cava Flow in Newborns
Status: COMPLETED
Conditions: Hemodynamic Instability
Interventions: DRUG: Dobutamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Additive Anti-inflammatory Action for Aortopathy & Arteriopathy (Rosuvastatin) I
Status: UNKNOWN
Conditions: Acute Aortic Syndrome|Aortopathy
Interventions: DRUG: Rosuvastatin 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest
Status: COMPLETED
Conditions: Cardiac Arrest
Interventions: DRUG: Adrenaline|DRUG: Vasopressin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Safety and Effectiveness of GDC-0032 When Given Alongside Tamoxifen
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: GDC-0032|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Characterization of High Density Lipoprotein (HDL) in Type 2 Diabetes (T2D) After Fenofibrate or Niacin Treatment
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Dyslipidemia
Interventions: DRUG: Fenofibrate|DRUG: Niacin plus laropiprant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Endoscopic Mucosal Resection and Cellular Matrix
Status: TERMINATED
Conditions: Barretts Esophagus With High Grade Dysplasia|Barrett Adenocarcinoma
Interventions: DEVICE: Acell MatriStem® Surgical Matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Investigation of the Efficacy of 2.5% and 5% Cis-urocanic Acid in Patients With Moderate or Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Cis-UCA 2.5% emulsion cream|DRUG: Cis-UCA 5% emulsion cream|DRUG: Placebo for cis-UCA emulsion cream|DRUG: Protopic® 0.1% ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicentric, Prospective, Randomized, Comparing Trial Between Bypass of the Femoropoplitea by PTFE and Heparin Bounded PTFE
Status: COMPLETED
Conditions: Peripheral Vascular Diseases
Interventions: DEVICE: Bridging by PTFE with bounded heparin|DEVICE: Bridging by PTFE without bounded heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endogenous Opioid Activity and Affective State in Insulin Resistant Women
Status: COMPLETED
Conditions: Depression|Insulin Resistance|Metabolic Syndrome
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility of the Gamification of Incentive Spirometry in Trauma Patients
Status: NOT_YET_RECRUITING
Conditions: Thoracic Trauma
Interventions: DEVICE: OmniFlow Breathing Therapy BioFeeback System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Steroids in Children Hospitalized With Asthma
Status: TERMINATED
Conditions: Asthma|Status Asthmaticus|Wheezes
Interventions: DRUG: Dexamethasone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab, Romidepsin, and Lenalidomide in Treating Patients With Recurrent or Refractory B-cell Non-Hodgkin Lymphoma
Status: WITHDRAWN
Conditions: B-cell Adult Acute Lymphoblastic Leukemia|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Refractory Hairy Cell Leukemia|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Testicular Lymphoma|Waldenström Macroglobulinemia
Interventions: BIOLOGICAL: rituximab|DRUG: lenalidomide|DRUG: romidepsin|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Rosuvastatin and Eicosapentaenoic Acid on Neoatherosclerosis: The LINK-IT Trial
Status: COMPLETED
Conditions: Coronary Artery Disease Progression
Interventions: DRUG: EPA and high dose rosuvastatin|DRUG: Standard dose rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physiotherapy in the Treatment of Breastfeeding Difficulties
Status: COMPLETED
Conditions: Breastfeeding|Ankyloglossia|Lactation Disorders
Interventions: PROCEDURE: Myofunctional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin Therapy in Concussion Management: A Randomized Control Trial
Status: TERMINATED
Conditions: Concussion
Interventions: DIETARY_SUPPLEMENT: Experimental: Vitamin Mixture|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ph 2 Study of the Safety and Efficacy of Three HU6 Dose Levels and Placebo in Nonalcoholic Steatohepatitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease|Nonalcoholic Steatohepatitis|Fatty Liver
Interventions: DRUG: HU6|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is Sheep Ghee Cardioprotective?
Status: COMPLETED
Conditions: Cholesterol; Metabolic Disorder|Inflammation
Interventions: DIETARY_SUPPLEMENT: sheep ghee|DIETARY_SUPPLEMENT: sunflower oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bio-markers of Not-celiac Wheat Sensitivity
Status: RECRUITING
Conditions: Not-celiac Wheat Sensitivity
Interventions: DIETARY_SUPPLEMENT: wheat flour|DIETARY_SUPPLEMENT: Xylose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Talactoferrin Alfa in Patients With Severe Sepsis
Status: SUSPENDED
Conditions: Severe Sepsis
Interventions: DRUG: Talactoferrin alfa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ketamine Versus Lidocaine Nebulization for Awake Fiberoptic Intubation
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Ketamine|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: To Improve the Rate of Mother's Own Milk Feeding of Premature Infants in NICU
Status: UNKNOWN
Conditions: Quality Improvement|Breast-feeding|Premature Infant
Interventions: BEHAVIORAL: Experimental: Intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combined PD1 Inhibitor and Decitabine in Elderly Patients With Relapse and Refractory Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Camrelizumab(SHR-1210)|DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Liposome-entrapped Mitoxantrone Hydrochloride Injection in Relapsed/Refractory Peripheral T-cell Lymphoma and NK/T-cell Lymphoma
Status: UNKNOWN
Conditions: Relapsed or Refractory Peripheral T-cell and NK/T-cell Lymphoma
Interventions: DRUG: Mitoxantrone Hydrochloride Liposome Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Pecs Blocks in Combination With Exparel in Breast Reconstruction Surgery
Status: RECRUITING
Conditions: Mammaplasty
Interventions: PROCEDURE: Breast Reconstruction (Mammaplasty)|DEVICE: Pecs blocks|DRUG: Exparel|DRUG: Bupivacaine|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of the CDK4/6 Inhibitor Abemaciclib in Solid Tumors Harboring Genetic Alterations in Genes Encoding D-type Cyclins or Amplification of CDK4 or CDK6
Status: RECRUITING
Conditions: Cancer
Interventions: DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Effect Mechanism of Lever Positioning Manipulation on LDH Analgesia Based on Multimodal MRI
Status: ACTIVE_NOT_RECRUITING
Conditions: Lumbar Disc Herniation|Multimodal Brain Function|Analgesia Mechanism|Lever Positioning Manipulation
Interventions: PROCEDURE: Group1 (lever positioning manipulation)|PROCEDURE: Group2 (placebo group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Pharmacokinetics of Meperizumab Injection and NUCALA® in Healthy Male Volunteers
Status: UNKNOWN
Conditions: Granulomatosis With Polyangiitis|Hemophagocytic Syndrome
Interventions: DRUG: Meperizumab injection|DRUG: NUCALA®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Wound Infiltration by Ketamine Versus Dexmedetomidine Added to Bupivacaine on Surgical Stress
Status: COMPLETED
Conditions: Abdominal Cancer
Interventions: DRUG: Dexmedetomidine|DRUG: Ketamine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of S-ketamine Anesthetic on Inflammatory Response in Septic Patients Undergoing Abdominal Surgery
Status: UNKNOWN
Conditions: Sepsis|Acute Lung Injury
Interventions: DRUG: S-ketamine|OTHER: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Brentuximab Vedotin in Patients With R/R PTCL Treated With Gemcitabine
Status: COMPLETED
Conditions: Refractory Peripheral T-Cell Lymphoma|Relapsed Peripheral T-Cell Lymphoma
Interventions: DRUG: Brentuximab Vedotin - induction|DRUG: Gemcitabine|DRUG: Brentuximab Vedotin - maintenance|PROCEDURE: autologous or allogeneic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Convalescent Plasma Therapy in the Early Care of COVID-19 Patients.
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Transfusion of SARS-CoV-2 Convalescent Plasma.|DRUG: Transfusion of standard Plasma.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Left Bundle Branch Area Versus Right Ventricular Septal Pacing in Patients With High-degree Conduction Disease After Transcatheter Aortic Valve Replacement (Left Bundle BRAVE)
Status: RECRUITING
Conditions: Complete Heart Block|High Degree Second Degree Atrioventricular Block|Pacemaker-Induced Cardiomyopathy|Aortic Valve Stenosis
Interventions: DEVICE: Right ventricular septal pacing followed by left bundle branch area pacing|DEVICE: Left bundle branch area pacing followed by right ventricular septal pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biopsychosocial Influence on Shoulder Pain
Status: COMPLETED
Conditions: Shoulder Pain
Interventions: DRUG: Propranolol LA (60 mg)|DRUG: Placebo|BEHAVIORAL: Shoulder Anatomy Education|BEHAVIORAL: Pain Processing Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FLAME: Investigate the Benefit of a Focal Lesion Ablative Microboost in Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Radiotherapy|MRI
Interventions: RADIATION: FLAME boost|RADIATION: standard arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Oral Deucrictibant Soft Capsule for On-Demand Treatment of Angioedema Attacks in Adolescents and Adults With Hereditary Angioedema
Status: RECRUITING
Conditions: Hereditary Angioedema|Hereditary Angioedema Type I|Hereditary Angioedema Type II|Hereditary Angioedema Types I and II|Hereditary Angioedema Attack|Hereditary Angioedema With C1 Esterase Inhibitor Deficiency|Hereditary Angioedema - Type 1|Hereditary Angioedema - Type 2|C1 Esterase Inhibitor [C1-INH] Deficiency|C1 Esterase Inhibitor Deficiency|C1 Esterase Inhibitor, Deficiency of|C1 Inhibitor Deficiency
Interventions: DRUG: Deucrictibant, Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zidovudine / Lamivudine + Nevirapine Twice Daily, Versus Tenofovir + Lamivudine + Nevirapine Once Daily in ARV-Naive Patients
Status: UNKNOWN
Conditions: Hiv Infection With Antiretroviral Therapy Indication|CD4 Below 350/µL or Below 15%
Interventions: DRUG: Nevirapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study to Investigate the Bioavailability and Tolerability of 3 Oral Formulations of Sodium Thiosulfate
Status: WITHDRAWN
Conditions: Healthy
Interventions: DRUG: Sodium thiosulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Phase II Study of HMPL-504 in Lung Sarcomatoid Carcinoma and Other Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Lung Sarcomatoid Carcinoma
Interventions: DRUG: Savolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-use Efficiency Instruments With Patient Specific Technique (MyKnee®) Versus Traditional Metal Instruments With Conventional Surgical Technique
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: Customized patient instruments|DEVICE: Traditional Metal Instruments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: a-tDCS Combined With Aerobic Exercise in Healthy Individuals
Status: UNKNOWN
Conditions: Healthy
Interventions: DEVICE: Real tDCS|DEVICE: Sham tDCS|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Ruxolitinib in Pancreatic Cancer Patients (Janus 1)
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: Ruxolitinib|DRUG: Placebo|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Angiography Derived Index of Microcirculatory Resistance in Patients With Acute Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction (AMI)
Interventions: OTHER: Angiography derived index of micro-circulatory resistance (Angio-IMR)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Benefits of Administering Immunosuppressive Drugs as Single Daily Doses Over the First Year After Liver Transplantation (EASY)
Status: NOT_YET_RECRUITING
Conditions: Liver Transplantation|Immunosuppression
Interventions: DRUG: XR-tacrolimus QD + MMF BID|DRUG: LCP-tacrolimus QD + MMF BID|DRUG: LCP-tacrolimus QD + MMF QD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Activity to Reduce Cardiometabolic Risk in Adults With Serious Mental Illness (PARCS) Study
Status: ENROLLING_BY_INVITATION
Conditions: Mental Disorders, Severe|Mental Illness Persistent
Interventions: BEHAVIORAL: Park-based physical activity|BEHAVIORAL: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION