pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Clinical Trial to Determine the Most Suitable Dose of OPB-111001 in Patients With Advanced Cancer
Status: TERMINATED
Conditions: Prostate Cancer|Salivary Gland Cancer|Endometrial Cancer|Squamous Cell Carcinoma of the Cervix|Breast Cancer|Ovarian Cancer
Interventions: DRUG: OPB-111001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ambroxol in New and Early DLB, A Phase IIa Multicentre Randomized Controlled Double Blind Clinical Trial
Status: RECRUITING
Conditions: Dementia With Lewy Bodies
Interventions: DRUG: Ambroxol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Corticospinal Excitability of Deep Back and Abdominal Muscles
Status: COMPLETED
Conditions: Instability; Back|Tightness of Back Muscles
Interventions: OTHER: Lumbopelvic stiffening technique|OTHER: Lumbopelvic relaxing technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment With Ziprasidone for Schizophrenia Patients With Obsessive Compulsive Disorder (OCD)
Status: COMPLETED
Conditions: Schizophrenia|Obsessive Compulsive Disorder
Interventions: DRUG: Ziprasidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Dose Escalation, Safety and Pharmacokinetic Study of AVE8062 Combined With Docetaxel in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Neoplastic Disease
Interventions: DRUG: AVE8062|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Breather in COPD Patients With Intermittent Claudication
Status: NOT_YET_RECRUITING
Conditions: COPD|PAD
Interventions: DEVICE: The BREATHER|DRUG: pharmacological treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: The Kessler Foundation modified Story Memory Technique® (KF-mSMT®)|BEHAVIORAL: Aerobic Exercise Training (AET) plus Virtual Reality (IDEAL)|BEHAVIORAL: Stretching and Toning (S/T)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PAS for Lower Extremity Rehabilitation in Tetraplegic Patients
Status: COMPLETED
Conditions: Spinal Cord Injuries|Spinal Cord Diseases
Interventions: DEVICE: Paired associative stimulation (with eXimia magnetic stimulator and Dantec Keypoint® electroneuromyography device)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Valproic Acid in Patients With Advanced Thyroid Cancers of Follicular Cell Origin
Status: COMPLETED
Conditions: Thyroid Neoplasm
Interventions: DRUG: Valproic Acid|DRUG: Liothyronine Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "TransRadial Ultra Support Technique" (TRUST)
Status: COMPLETED
Conditions: Coronary Arterioscleroses|Coronary Artery Disease
Interventions: PROCEDURE: TRUST technique|PROCEDURE: Anchoring Technique|PROCEDURE: Coronary stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Immunogenicity of Polyvalent DNA/gp120 HIV Vaccine in Healthy, HIV-uninfected Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: env (A,B,C,A/E)/gag (C) DNA Vaccine|BIOLOGICAL: gp120 (A,B,C,A/E) Protein Vaccine|BIOLOGICAL: GLA-SE adjuvant|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: NAC for Treating Comorbid PTSD and SUD
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder (PTSD)|Alcohol Use Disorder (AUD)|Substance Use Disorder (SUD)
Interventions: DRUG: N-acetylcysteine|DRUG: Placebo|BEHAVIORAL: Cognitive behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy for the Treatment of Advanced Solid Tumor
Status: RECRUITING
Conditions: Recurrence Tumor|Metastatic Cancer|Solid Tumor
Interventions: BIOLOGICAL: TIL|DRUG: Aldesleukin|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficay and Safety of Empagliflozin Versus Sitagliptin for the In-patient Management of Hyperglycemia
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: Empagliflozin 25 MG|DRUG: Sitagliptin 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Safety and Tolerability of CKD-387 10/500mg BE Phase1
Status: COMPLETED
Conditions: Type2 Diabetes Mellitus
Interventions: DRUG: Part A, Reference (D635 10/500mg, Astrazeneca)|DRUG: Part A, Reference (D635 10/500mg, Astrazeneca)|DRUG: Part B, Reference (D635 10/500mg, Astrazeneca)|DRUG: Part B, Reference (D635 10/500mg, Astrazeneca)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Imaging of Peripheral Arteries by Optical Coherence Tomography and Intravascular Ultrasound Imaging
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: DEVICE: IVUS and OCT Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Antineoplaston Therapy in Treating Patients With Metastatic or Unresectable Colon Cancer
Status: TERMINATED
Conditions: Colon Cancer
Interventions: DRUG: antineoplaston A10, antineoplaston AS2-1 (ANP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutrition and Physical Activity Intervention in Preventing Excess Weight Gain in Pediatric Patients With Leukemia or Lymphoma Treated With Prednisone and/or Dexamethasone
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia|Lymphoma
Interventions: OTHER: Counseling|BEHAVIORAL: Exercise Intervention|OTHER: Informational Intervention|DIETARY_SUPPLEMENT: Nutritional Intervention|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ondansetron Effect on Pain Relief After Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Cholecystitis
Interventions: DRUG: Ondansetron|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Lu AF95245 in Healthy Young Men
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: Lu AF95245|DRUG: Lu AF95245 14C radiolabelled spiked dosage|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity of Adjuvanted or Non-adjuvanted H5N1 Booster Vaccine in Adults Primed to A/VN/1194/04
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Aflunov (Single prime, single boost)|BIOLOGICAL: Aflunov (Single prime, single boost)|BIOLOGICAL: Aflunov (single prime, single boost)|BIOLOGICAL: Aflunov (single prime, single boost)|BIOLOGICAL: Aflunov (Double prime, single boost)|BIOLOGICAL: Aflunov (double prime, single boost)|BIOLOGICAL: Aflunov (double prime, single boost)|BIOLOGICAL: Aflunov (double prime, single boost)|BIOLOGICAL: Aflunov (No prime, single boost)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: WIC-Based Intervention to Promote Healthy Eating Among Low-Income Mothers
Status: COMPLETED
Conditions: Cancer Prevention|Diet Modification|Vegetable Intake
Interventions: BEHAVIORAL: Multilevel Behavioral Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Hallelujah Acres Omega 3 Fat Study
Status: COMPLETED
Conditions: Omega 3 Fat Status
Interventions: DIETARY_SUPPLEMENT: Organic flax seed oil|DIETARY_SUPPLEMENT: fish oil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Efficacy Study of Secukinumab in Plaque Psoriasis Patients With Subclinical Psoriatic Arthritis as Measured by Musculoskeletal Ultrasound
Status: WITHDRAWN
Conditions: Psoriasis
Interventions: BIOLOGICAL: Secukinumab 300 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Catheter Ablation Versus Amiodarone for Therapy of Premature Ventricular Contractions in Patients With Structural Heart Disease
Status: COMPLETED
Conditions: Heart Diseases|Cardiomyopathies|Ventricular Premature Complexes
Interventions: PROCEDURE: Procedure (Radiofrequency catheter ablation)|DRUG: Amiodarone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effects of Hydroxyvitamin D3 on Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis, Relapsing-Remitting|Adult ALL|Vitamin D3 Deficiency
Interventions: DIETARY_SUPPLEMENT: 25(OH)D3|DIETARY_SUPPLEMENT: vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Combined With Immunotherapy After Induction Therapy With Chemotherapy and Targeted Therapy in the First-line Treatment of Microsatellite Stable (MSS) Initially Unresectable Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Vaccine Hesitancy (VH) And Vaccine Refusal (VR): Its' Correlation Factors and an Educational Intervention Programme
Status: UNKNOWN
Conditions: COVID-19 Vaccination
Interventions: BEHAVIORAL: Reducing Vaccine Hesitancy (VH) And Vaccine Refusal (VR): An Educational Intervention Programme|BEHAVIORAL: Reducing Vaccine Hesitancy (VH) And Vaccine Refusal (VR): An Educational Intervention Programme|BEHAVIORAL: Reducing Vaccine Hesitancy (VH) And Vaccine Refusal (VR): An Educational Intervention Programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase 3 Study to Compare the Efficacy and Safety of Eribulin With Dacarbazine in Subjects With Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: Eribulin mesylate 1.4 mg/m^2 intravenous|DRUG: Dacarbazine of 850 mg/m^2, or 1,000 mg/m^2, or 1,200 mg/m^2 IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Horizon Adaptive Platform Trial Evaluating Therapies in RRMM
Status: NOT_YET_RECRUITING
Conditions: Relapse Multiple Myeloma|Refractory Multiple Myeloma
Interventions: DRUG: Teclistamab|DRUG: Investigational Agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effects of taVNS on Inhibitory Control
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Vagus nerve stimulation via tragus|DEVICE: Sham stimulation via earlobe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: This Study Will Evaluate the Safety, Tolerability, and Efficacy of ANB032 in Subjects With Moderate to Severe Atopic Dermatitis (AD).
Status: ACTIVE_NOT_RECRUITING
Conditions: Atopic Dermatitis Eczema
Interventions: DRUG: ANB032|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ublituximab in Combination With TGR-1202 +/- Ibrutinib or Bendamustine in Patients With B-cell Malignancies
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Non-Hodgkin's Lymphoma
Interventions: DRUG: Ublituximab + TGR-1202|DRUG: Ublituximab + TGR-1202 + ibrutinib|DRUG: Ublituximab + TGR-1202 + bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Megestrol in Treating Patients Who Are Undergoing Radiation Therapy for Lung Cancer
Status: COMPLETED
Conditions: Anorexia|Cachexia|Lung Cancer
Interventions: DRUG: megestrol acetate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Myocardial Fibrosis Progression in Duchenne and Becker Muscular Dystrophy - ACE Inhibitor Therapy Trial
Status: COMPLETED
Conditions: Myocardial Fibrosis|Muscular Dystrophies
Interventions: DRUG: Enalapril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effect of SANGUINATE™ Infusion in Patients at Risk of Delayed Cerebral Ischemia (DCI) Following Subarachnoid Hemorrhage (SAH)
Status: COMPLETED
Conditions: Cerebral Ischemia
Interventions: BIOLOGICAL: SANGUINATE™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Fixation of the Posterior Malleolus in Trimalleolar AO Weber C Fractures.
Status: UNKNOWN
Conditions: Trimalleolar Fracture|AO Weber C Fractures|Syndesmotic Stability|Open Reduction and Internal Fixation
Interventions: DEVICE: Fixation|DEVICE: NO Fixation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Single-dose MY008211A in Healthy Adults
Status: COMPLETED
Conditions: Paroxysmal Nocturnal Hemoglobinuria
Interventions: DRUG: MY008211A tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Temsirolimus With or Without Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Cancer Who Did Not Respond to Previous Therapy
Status: COMPLETED
Conditions: Recurrent Hypopharyngeal Squamous Cell Carcinoma|Recurrent Laryngeal Squamous Cell Carcinoma|Recurrent Laryngeal Verrucous Carcinoma|Recurrent Lip and Oral Cavity Squamous Cell Carcinoma|Recurrent Metastatic Squamous Cell Carcinoma in the Neck With Occult Primary|Recurrent Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Recurrent Nasopharyngeal Keratinizing Squamous Cell Carcinoma|Recurrent Oral Cavity Verrucous Carcinoma|Recurrent Oropharyngeal Squamous Cell Carcinoma|Recurrent Salivary Gland Carcinoma|Salivary Gland Squamous Cell Carcinoma|Squamous Cell Carcinoma Metastatic in the Neck With Occult Primary|Stage IV Hypopharyngeal Squamous Cell Carcinoma|Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma|Stage IVA Laryngeal Squamous Cell Carcinoma|Stage IVA Laryngeal Verrucous Carcinoma|Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma|Stage IVA Major Salivary Gland Carcinoma|Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVA Oral Cavity Verrucous Carcinoma|Stage IVA Oropharyngeal Squamous Cell Carcinoma|Stage IVB Laryngeal Squamous Cell Carcinoma|Stage IVB Laryngeal Verrucous Carcinoma|Stage IVB Lip and Oral Cavity Squamous Cell Carcinoma|Stage IVB Major Salivary Gland Carcinoma|Stage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVB Oral Cavity Verrucous Carcinoma|Stage IVB Oropharyngeal Squamous Cell Carcinoma|Stage IVC Laryngeal Squamous Cell Carcinoma|Stage IVC Laryngeal Verrucous Carcinoma|Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma|Stage IVC Major Salivary Gland Carcinoma|Stage IVC Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVC Oral Cavity Verrucous Carcinoma|Stage IVC Oropharyngeal Squamous Cell Carcinoma|Tongue Carcinoma
Interventions: BIOLOGICAL: Cetuximab|OTHER: Laboratory Biomarker Analysis|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NUPRO Sensodyne Prophylaxis Paste With NovaMin Sensitivity Relief Study
Status: COMPLETED
Conditions: Tooth Hypersensitivity
Interventions: DEVICE: Group C|DEVICE: Group A|DEVICE: Group B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Time Restricted Feeding in Autosomal Dominant Polycystic Kidney Disease
Status: COMPLETED
Conditions: Polycystic Kidney, Autosomal Dominant
Interventions: BEHAVIORAL: Dietary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Dose Optimisation Study of ART621 in Subjects Diagnosed With Rheumatoid Arthritis Taking Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: ART621|DRUG: ART621|DRUG: ART621|DRUG: ART621|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Toothbrush Bristles in Plaque Reduction
Status: COMPLETED
Conditions: Plaque, Dental|Gingivitis
Interventions: DEVICE: Tapered bristles A|DEVICE: Tapered bristles B|DEVICE: End rounded bristles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Fraction Dose Escalation of Split-course Hypofractionated Concurrent Chemoradiotherapy Following Induction Chemo-immunotherapy in Unresectable Locally Advanced Esophageal Squamous Carcinoma: a Phase I Study.
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: RADIATION: Split-course hypo-CCRT|DRUG: Induction chemo-immunotherapy|DRUG: Concurrent chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Determine the Safety and Tolerability of Sirolimus Given With Hyper-CVAD Chemotherapy
Status: COMPLETED
Conditions: Lymphoid Malignancies (New or Relapsed)|Acute Lymphoblastic Leukemia|Burkitt Lymphoma|Lymphoblastic Lymphoma|Mantle Cell Lymphoma|Adult T-cell Leukemia/Lymphoma
Interventions: DRUG: Hyper-CVAD|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visual Activity Evoked by Infrared in Humans After Dark Adaptation
Status: COMPLETED
Conditions: Age Related Macular Degeneration|Retinitis Pigmentosa|Congenital Stationary Night Blindness|Colorblindness
Interventions: OTHER: Tungsten halogen light with narrow bandpass filters|OTHER: ERG|OTHER: VEP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Nicotinamide Riboside and Mitochondrial Metabolism
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: NR in BMI-discordant twins|DIETARY_SUPPLEMENT: NR in BMI-concordant twins
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-030)-China Extension
Status: COMPLETED
Conditions: Chronic Cough
Interventions: DRUG: Gefapixant 45 mg twice daily (BID)|DRUG: Gefapixant 15 mg BID|DRUG: Placebo|DRUG: Gefapixant 45 mg BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation of Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC)
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Sorafenib (BAY-43-9006)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOLFOX + Immunotherapy With Intrahepatic Oxaliplatin for Patients With Metastatic Colorectal Cancer
Status: WITHDRAWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Oxaliplatin|DRUG: 5-Fluorouracil|DRUG: Leucovorin|DRUG: Nivolumab|DEVICE: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2b/3 Study to Assess ABP-671 a Novel URAT1 Inhibitor in Participants With Gout
Status: ACTIVE_NOT_RECRUITING
Conditions: Gout
Interventions: DRUG: ABP-671|DRUG: Allopurinol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transoral Incisionless Fundoplication (TIF) Registry Study for Treatment of Gastroesophageal Reflux Disease (GERD)
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease|Hiatal Hernia
Interventions: PROCEDURE: TIF Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study Comparing 2 Doses Of CP-690,550 And The Active Comparator, Humira (Adalimumab) Vs. Placebo For Treatment Of Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: CP 690,550|DRUG: CP-690,550|OTHER: Placebo|OTHER: Placebo|BIOLOGICAL: Biologic TNFi
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab and Liposomal Doxorubicin in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: pegylated liposomal doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Activity of Abiraterone Acetate in the Management of Cushing's Syndrome in Patients With Adrenocortical Carcinoma
Status: UNKNOWN
Conditions: Cushing Syndrome|Adrenocortical Carcinoma
Interventions: DRUG: Abiraterone Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The BOOSTED (Booster Options Or Switching Tested for Effectiveness and Downsides Study) Trial (COVID-19)
Status: COMPLETED
Conditions: COVID-19|Vaccine Reaction|COVID-19 Pandemic
Interventions: BEHAVIORAL: Moderna Booster Vaccine|BEHAVIORAL: Pfizer Booster Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Two Different Videolaryngoscopes Regarding Hemodynamic Parameters in Open Heart Surgey
Status: COMPLETED
Conditions: Intubation;Difficult|Coronary Bypass
Interventions: DEVICE: airtraq|DEVICE: storz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Genetic and Molecular Abnormalities in Congenital Cystic Adenomatoid Malformations
Status: COMPLETED
Conditions: Congenital Cystic Adenomatoid Malformation (CCAM)
Interventions: GENETIC: Patient
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: DRUG: Leucovorin|DRUG: Oxaliplatin|DRUG: Fluoruracil|DRUG: Capecitabine|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Preservation of Scarpa's Fascia in Abdominoplasty
Status: WITHDRAWN
Conditions: Abdominoplasty
Interventions: PROCEDURE: Abdominoplasty-Scarpa's fascia preservation|PROCEDURE: Abdominoplasty-Scarpa's fascia ablation|DEVICE: Lymphoscintigraphy|DEVICE: 3D Imaging|DEVICE: Abdominal ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Non-nutritive Sweeteners of High Sugar Sweetened Beverages on Metabolic Health and Gut Microbiome
Status: ACTIVE_NOT_RECRUITING
Conditions: Gut Microbiota|Metabolic Syndrome
Interventions: OTHER: 710 ml of regular soft drinks, taken daily for 10 weeks|OTHER: 710 ml of diet soft drinks, taken daily for 10 weeks|OTHER: 710 ml of stevia-sweetened soft drinks, taken daily for 10 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Camrelizumab Combined With Cisplatin in the Treatment of Advanced Cutaneous Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Squamous Cell Carcinoma of the Skin
Interventions: DRUG: Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravenous Immunglobulin (IVIG) After Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Octagam (IVIG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Local Delivery of Aloe Vera Gel as an Adjunct to Non-surgical Treatment in Patients With Chronic Periodontitis
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: OTHER: Aloe vera after SRP|PROCEDURE: Scaling and root planing (SRP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial Comparing the BAGUERA C to the Marketed Mobi-C® for the Treatment of Cervical Disc Disease at 2 Contiguous Levels
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Disc Disease
Interventions: DEVICE: BAGUERA®C Cervical Disc Prosthesis|DEVICE: Mobi-C Cervical Disc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of the Use of Brushite as Primary Stabilizer in Immediate Dental Implantation
Status: SUSPENDED
Conditions: Alveolar Ridge Augmentation|Dental Implants
Interventions: PROCEDURE: using "PD" VitalOs Cement with dental implants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Does Distraction With a Hand Held Video Game Reduce Preoperative and Emergence Anxiety in Children?
Status: COMPLETED
Conditions: Pediatric Emergence Agitation and Pain
Interventions: DRUG: Midazolam|DEVICE: Game Boy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy and Safety of SCTA01 in Hospitalized Patients With Severe COVID-19
Status: UNKNOWN
Conditions: Covid19
Interventions: DRUG: SCTA01|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dark Halo and MNV: a Study Between ICGA and OCTA
Status: COMPLETED
Conditions: Macular Neovascularisation
Interventions: DIAGNOSTIC_TEST: Optical Coherence Tomography Angiography (OCTA) and indocyanine green angiography (ICGA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Perioperative Intravenous Lidocaine Infusion on Opioid Consumption After Lumbar Spine Surgery
Status: TERMINATED
Conditions: Pain, Postoperative|Opioid Use
Interventions: DRUG: Intravenous Lidocaine Infusion|DRUG: Placebo Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: E-Health Literacy, Digital Literacy, Healthy Lifestyle and Web Based Education for Young Old Individuals
Status: COMPLETED
Conditions: Healthy Lifestyle
Interventions: DIAGNOSTIC_TEST: Web Based Training on E-health Literacy, Digital Literacy and Healthy Lifestyle Behaviors.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optimal Verbal Instruction to Improve Walking for PD
Status: COMPLETED
Conditions: Parkinson Disease|Gait Disorders, Neurologic
Interventions: BEHAVIORAL: Treadmill gait training with verbal instruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Developing and Treating a Mouse Model of Acute Myeloid Leukemia Using Tissue Samples From Younger Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies
Interventions: OTHER: laboratory biomarker analysis|DRUG: quizartinib|DRUG: sorafenib tosylate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Extended-release of Octreotide (LF-PB) for the Treatment of Lymphorrhea
Status: COMPLETED
Conditions: Lymphorrhea
Interventions: DRUG: LF-PB and Placebo|DRUG: Placebo|DRUG: LF-PB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone vs Placebo in the Prophylaxis of Radiation-Induced Pain Flare Following Palliative Radiotherapy for Bone Metastases
Status: COMPLETED
Conditions: Bone Metastases
Interventions: DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Flow in Cerebrospinal Fluid Shunts With a Wireless Thermal Anisotropy Measurement Device in Asymptomatic Patients
Status: NOT_YET_RECRUITING
Conditions: Hydrocephalus
Interventions: DEVICE: Thermal Anisotropy Measurement Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: HEALEY ALS Platform Trial - Regimen E SLS-005 - Trehalose
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: SLS-005|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Intrathecal Morphine With Placebo In Patients Undergoing Robotic Cardiac Surgery
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Intrathecal morphine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Open Label, Clinical Study of the Targeted Therapy, Palbociclib, to Treat Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: HER-2 Positive Breast Cancer|Estrogen Receptor Positive Breast Cancer
Interventions: DRUG: palbociclib|DRUG: trastuzumab|DRUG: pertuzumab|DRUG: letrozole|DRUG: Anastrozole|DRUG: Exemestane|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic-Dose Safety and Efficacy Study of Albuterol-HFA-BAI in Pediatric Asthmatics
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Albuterol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Determine the Maximum Tolerated Dose Level (MTD) of PEP005 Topical Gel in Patients With sBCC
Status: COMPLETED
Conditions: Superficial Basal Cell Carcinoma
Interventions: DRUG: PEP005
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acetazolamide as a Means to Mitigate Falling Ventilatory Drive and Drive-dependent OSA
Status: RECRUITING
Conditions: OSA
Interventions: DRUG: Acetazolamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center, Open-Label, Multiple Dose, Dose Finding Study Exploring the Safety and Tolerability of Beraprost Sodium Modified Release in PAH Patients
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Beraprost sodium modified release
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Irbesartan High/Amlodipine FDC and Co-administration of Irbesartan High and Amlodipine in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Irbesartan High/Amlodipine FDC|DRUG: Irbesartan High|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Valsartan on Proteinuria in Patients With Hypertension and Diabetes Mellitus
Status: COMPLETED
Conditions: PROTEINURIA|Hypertension|Type 2 Diabetes
Interventions: DRUG: valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Use of Sildenafil (Viagra) to Alter Fatigue, Functional Status and Impaired Cerebral Blood Flow in Patients With CFS
Status: COMPLETED
Conditions: Chronic Fatigue Syndrome
Interventions: DRUG: Sildenafil (Viagra)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of AZD4831 in Patients With Heart Failure.
Status: TERMINATED
Conditions: Heart Failure
Interventions: DRUG: AZD4831|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-duration EPBD vs EST for Removal of Biliary Stones
Status: UNKNOWN
Conditions: Cholangiopancreatography, Endoscopic Retrograde
Interventions: PROCEDURE: long duration EPBD|PROCEDURE: EST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Treating Liver Cancer With Drug-Eluting Beads
Status: TERMINATED
Conditions: Neoplasm Metastases|Melanoma|Colorectal Neoplasms
Interventions: DRUG: Irinotecan|PROCEDURE: Chemoembolization|DEVICE: Drug-Eluting Beads|PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Zavegepant Concentration Using Samples Collected From the Vein Versus Patient-Centric Microsampling
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Zavegepant 10 mg IN
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of eOncoNote
Status: COMPLETED
Conditions: Communication Research|Breast Cancer|Prostate Cancer|Colorectal Cancer|Lung Cancer|Program, Communication|Remote Consultation
Interventions: BEHAVIORAL: eOncoNote
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: BRInging the Diabetes Prevention Program to GEriatric Populations
Status: RECRUITING
Conditions: Pre Diabetes
Interventions: OTHER: DPP Tailored for Older Adults and delivered via Telehealth|OTHER: In-Person Diabetes Prevention Program (DPP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 90 mg Fluoxetine Hydrochloride Capsules Under Non-Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Fluoxetine Hydrochloride|DRUG: PROZAC WEEKLY®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy and Safety Study of Rimegepant for Migraine Prevention in Japanese Subjects (Japan Only)
Status: ACTIVE_NOT_RECRUITING
Conditions: Migraine
Interventions: DRUG: Rimegepant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Immune Globulin Subcutaenous (Human), 20%
Status: COMPLETED
Conditions: Primary Immunodeficiency Diseases (PID)
Interventions: BIOLOGICAL: Immune Globulin Subcutaneous (Human), 20%|BIOLOGICAL: Immune Globulin Intravenous (Human), 10%|BIOLOGICAL: Human Normal Immunoglobulin (Subcutaneous - Intramuscular Immunoglobulin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal High CPAP Pressures in Preterm Neonates Post-extubation
Status: UNKNOWN
Conditions: Preterm Birth|Mechanical Ventilation Complication|Respiratory Distress Syndrome, Newborn
Interventions: OTHER: CPAP level
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Multisensory Stimulation and Enriched Environments During Post-traumatic Amnesia
Status: UNKNOWN
Conditions: Brain Injuries, Traumatic|Confusional State|Sensory Motor System Disorder|Alteration of Cognitive Function
Interventions: BEHAVIORAL: Multisensory stimulation protocol|BEHAVIORAL: Control protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of Doravirine (MK-1439) in Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Participants (MK-1439-005)
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Doravirine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing a Tdap-IPV Combined Vaccine With a Tetanus Monovalent Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: REPEVAX|BIOLOGICAL: Monovalent Tetanus vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Open-label Study of NRP104 in Adults With Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder|Attention Deficit Disorders With Hyperactivity|Attention Deficit Hyperactivity Disorders
Interventions: DRUG: Vyvanse (lisdexamfetamine dimesylate), NRP104
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of PD-L1 Antibody ZKAB001(Drug Code) in Limited Stage of High-grade Osteosarcoma
Status: UNKNOWN
Conditions: Osteosarcoma
Interventions: DRUG: ZKAB001 5mg/kg|DRUG: ZKAB001 10mg/kg|DRUG: ZKAB001 15mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Haemodynamic Assessment in Hypertension
Status: COMPLETED
Conditions: Arterial Hypertension
Interventions: DRUG: lisinopril|DRUG: Telmisartan|DRUG: Nebivolol|DRUG: Indapamide/hydrochlorothiazide|DRUG: Amlodipine|DRUG: lisinopril|DRUG: Telmisartan|DRUG: Nebivolol|DRUG: Indapamide/hydrochlorothiazide|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Long-term Outcome of DBS Versus Botulinum Toxin Treatment in Cervical Dystonia
Status: ENROLLING_BY_INVITATION
Conditions: Cervical Dystonia
Interventions: DEVICE: DBS-device, implanted in GPi bilaterally|DRUG: Botulinum toxin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Comparison of Two Daily Disposable Soft Contact Lenses
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: comfilcon A|DEVICE: somofilcon A|DEVICE: stenfilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study of TQB2303 in Patients With CD20-Positive Diffuse Large B-cell Lymphoma (DLBCL)
Status: UNKNOWN
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: TQB2303|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study of Single-port Robot-assisted Gastrectomy
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer
Interventions: DEVICE: SHURUI Endoscopic Surgical Robotic System (SR-ENS-600)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Brenner Tumor|Malignant Ascites|Malignant Pleural Effusion|Ovarian Clear Cell Cystadenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Mixed Epithelial Carcinoma|Ovarian Serous Cystadenocarcinoma|Ovarian Undifferentiated Adenocarcinoma|Recurrent Fallopian Tube Cancer|Recurrent Ovarian Epithelial Cancer|Recurrent Ovarian Germ Cell Tumor|Recurrent Primary Peritoneal Cavity Cancer|Stage IIIA Fallopian Tube Cancer|Stage IIIA Ovarian Epithelial Cancer|Stage IIIA Ovarian Germ Cell Tumor|Stage IIIA Primary Peritoneal Cavity Cancer|Stage IIIB Fallopian Tube Cancer|Stage IIIB Ovarian Epithelial Cancer|Stage IIIB Ovarian Germ Cell Tumor|Stage IIIB Primary Peritoneal Cavity Cancer|Stage IIIC Fallopian Tube Cancer|Stage IIIC Ovarian Epithelial Cancer|Stage IIIC Ovarian Germ Cell Tumor|Stage IIIC Primary Peritoneal Cavity Cancer|Stage IV Fallopian Tube Cancer|Stage IV Ovarian Epithelial Cancer|Stage IV Ovarian Germ Cell Tumor|Stage IV Primary Peritoneal Cavity Cancer
Interventions: DRUG: metformin hydrochloride|DRUG: placebo|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Esketamine on Consciousness-related Brain Network Characteristics in Patients With Prolonged Disorders of Consciousness
Status: RECRUITING
Conditions: Prolonged Disorders of Consciousness
Interventions: DRUG: Drug: Esketamine (Continuous infusion)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: FT516 in Combination With Monoclonal Antibodies in Advanced Solid Tumors
Status: TERMINATED
Conditions: Solid Tumor, Adult
Interventions: DRUG: FT516|DRUG: Avelumab|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Budesonia + Intratracheal Surfactant in Incidence of Bronchopulmonary Dysplasia
Status: UNKNOWN
Conditions: Respiratory Tract Diseases
Interventions: OTHER: intratracheal administration of surfactant/budesonide|OTHER: incidence of bronchopulmonary dysplasia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Paclitaxel, Carboplatin, and Cetuximab for Advanced Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study of Citalopram 40 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Citalopram HBr 40 mg tablets, single dose|DRUG: CelexaTM 40 mg tablets, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: