pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Role of Sleep Apnea in the Acute Exacerbation of Heart Failure
Status: COMPLETED
Conditions: Heart Failure|Obstructive Sleep Apnea|Heart Failure, Congestive
Interventions: DEVICE: CPAP Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Task Analysis Study of DECIDE For African American Patients With Type 2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: eDECIDE Web-based Intervention Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Virtual Reality Exposure and Respiratory Relaxation-Based Coping With Cocaine Craving in Cocaine Users
Status: COMPLETED
Conditions: Virtual Reality Exposure Therapy|Cocaine Use Disorder
Interventions: DEVICE: Virtual Reality Exposure to Neutral Cues|BEHAVIORAL: Respiratory Relaxation|DEVICE: Virtual Reality Exposure to Cocaine-Related Cues
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Instant Message-delivered Personalised Lifestyle Modification Intervention for Pre-hypertension Adults
Status: RECRUITING
Conditions: Pre-hypertension|Lifestyle Modification|Blood Pressure Management|Mobile Phone Use
Interventions: BEHAVIORAL: Receiving LSM messages.|BEHAVIORAL: Receiving brief pre-HTN messages.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Fungal Fiber for Gut Health
Status: RECRUITING
Conditions: Mild Gastrointestinal Symptoms in Healthy Adults|Low-grade Chronic Inflammation|Stress|Gut Health|Gut Permeability|Gut Microbiome|Immune Response|Activity of Daily Living|Nutrition, Healthy
Interventions: DIETARY_SUPPLEMENT: fungal fiber|DIETARY_SUPPLEMENT: inulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Analysis of Changes in Adipose Tissue of Patients With Lipoatrophy HIV Infection Treated With Nucleoside Thymidine, After Switching to Monotherapy With Lopinavir / Ritonavir
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: Kaletra
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Randomized, Placebo-controlled, Observer-blinded Phase 1 Safety and Immunogenicity Study of Inactivated Zika Virus Vaccine Candidate in Healthy Adults
Status: COMPLETED
Conditions: Zika Virus|Zika Virus Infection
Interventions: BIOLOGICAL: VLA1601|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dexamethasone Administered Via the Epidural Catheter as an Adjunct in Patients Undergoing Cesarean Delivery
Status: WITHDRAWN
Conditions: Post Operative Pain
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nurse-Led Community Health Worker Adherence Model in 3HP Delivery Among Homeless Adults at Risk for TB Infection and HIV
Status: COMPLETED
Conditions: Latent Tuberculosis Infection
Interventions: BEHAVIORAL: Nurse-led Community Health Worker TBI (RN/CHW TBI) program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dasatinib and Erlotinib in Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Lung Cancer|Non-Small Cell Lung Cancer
Interventions: DRUG: Dasatinib|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Maintenance Treatment With Rituximab Versus No Treatment in Participants With Progressive B-Cell Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Lymphocytic Leukemia, Chronic
Interventions: DRUG: Cladribine|DRUG: Cyclophosphamide|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study of a Mobile Application Intervention to Promote Strength and Balance Exercises in Older People
Status: COMPLETED
Conditions: Accidental Falls
Interventions: OTHER: Safe Step|OTHER: OEP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Effectiveness Study of a Non-Crosslinked HA Alkylamide HYADD(TM) 4 Hydrogel for Osteoarthritis of the Knee
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DEVICE: HYMOVIS|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Quadratus Lumborum Block Vs Fascia Iliaca Block in Pediatrics Undergoing Hip Surgery .
Status: UNKNOWN
Conditions: Developmental Dysplasia of the Hip
Interventions: PROCEDURE: ultrasound guided fascia iliaca block|PROCEDURE: ultrasound guided quadratus lumborum block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of a Silicone Hydrogel Daily Disposable Multifocal Contact Lens to a Marketed Product
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: JJVC Investigational Multifocal Contact Lenses|DEVICE: Dailies Total 1® Multifocal Contact Lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ketone Supplementation, Glucose Control, and Cardiovascular Function
Status: COMPLETED
Conditions: Hyperglycemia, Postprandial|Overweight and Obesity|Diabetes Mellitus Risk
Interventions: DIETARY_SUPPLEMENT: Exogenous ketone monoester
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Inertial Flywheel vs Heavy Slow Resistance Training Among Athletes With Patellar Tendinopathy
Status: COMPLETED
Conditions: Patellar Tendinitis|Jumper's Knee
Interventions: BEHAVIORAL: Exercises program for patellar tendinopathy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemoradiation With 5-FU(or Capecitabine) and Oxaliplatin Combined With Hyperthermia in Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: RADIATION: Radiotherapy|PROCEDURE: Hyperthermia|DRUG: 5-Fluorouracil|DRUG: Capecitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: QUILT-2.024: Phase 2 Neoadjuvant, Consolidation, and Adjuvant Combination NANT Immunotherapy Versus Standard of Care in Subjects With Resectable Non-small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Nab-paclitaxel|DRUG: Cisplatin|DRUG: 5Fluorouracil|DRUG: Cyclophosphamide|BIOLOGICAL: ETBX-011|BIOLOGICAL: ETBX-051|BIOLOGICAL: ETBX-061|BIOLOGICAL: GI-4000|BIOLOGICAL: GI-6301|DRUG: Aldoxorubicin|DRUG: Avelumab|DRUG: ALT-803|BIOLOGICAL: haNK|DRUG: Docetaxel|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Isavuconazole in the Treatment of Renally Impaired Aspergillosis and Rare Fungi
Status: COMPLETED
Conditions: Aspergillosis|Invasive Fungal Infections
Interventions: DRUG: isavuconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Home Exercise Activity on Cortisol and Depression in COPD During the Pandemic COVID
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: exercise group|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Xian-Lian-Jie-Du Optimization Decoction as an Adjuvant Treatment for Prevention of Recurrence of Colon Cancer
Status: RECRUITING
Conditions: Colon Cancer
Interventions: DRUG: XLJDOD compound granule|DRUG: placebo (XLJDOD mimetic agent)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Two Doses of Menactra® or One Dose of Monovalent Meningococcal Group C Vaccine With Routine Immunizations
Status: COMPLETED
Conditions: Meningitis|Meningococcal Infection
Interventions: BIOLOGICAL: Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate: Menactra®|BIOLOGICAL: Meningococcal Group C Conjugate vaccine: MenC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Apremilast in Palmo-Plantar Psoriasis
Status: COMPLETED
Conditions: Palmo-plantar Psoriasis
Interventions: DRUG: Apremilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PRF Pulpotomy Using Different Bioceramic Materials in Permanent Molars
Status: COMPLETED
Conditions: Irreversible Pulpitis
Interventions: PROCEDURE: portland cement|PROCEDURE: Mineral trioxide aggregate|PROCEDURE: Biodentine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adductor Canal Block Versus Periarticular Bupivicaine Injection in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Interventional Study of Videoconferences Between Hospital and Municipality - a Randomized Controlled Trial
Status: COMPLETED
Conditions: Discharge Planning|Readmission, Hospital
Interventions: OTHER: Review of discharges and cross-sectoral video conferencing immediately after discharge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Early Intervention to Prevent Lower Limb Lymphedema of Gynecological Malignancy
Status: RECRUITING
Conditions: Uterine Cervical Neoplasms|Endometrial Neoplasms|Lymphedema|Treatment Effectiveness
Interventions: BEHAVIORAL: Prophylactic lymphedema treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: tDCS and Prismatic Adaptation: Roles of the Cerebellum and the Primary Motor Cortex in the Transfer of After-effects
Status: WITHDRAWN
Conditions: Healthy Volunteers
Interventions: DEVICE: tDCS (transcranial direct current stimulation)|BEHAVIORAL: Virtual reality device|DEVICE: tDCS (transcranial direct current stimulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Long-term Antibiotics for Treatment and Prevention of Otitis Media in Aborignal Children
Status: COMPLETED
Conditions: Otitis Media
Interventions: DRUG: Amoxycillin|DRUG: Placebo equivalent to amoxycillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Miltefosine in Antihistamine Resistant Chronic Urticaria
Status: TERMINATED
Conditions: Chronic Urticaria
Interventions: DRUG: Miltefosine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prazosin vs Paroxetine in Combat Stress-Related Post-Traumatic Stress Disorder (PTSD) Nightmares & Sleep Disturbance
Status: TERMINATED
Conditions: Stress Disorders, Post-Traumatic|Sleep Disorders
Interventions: DRUG: prazosin|DRUG: paroxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PET/MRI for Men Being Considered for Radiotherapy for Suspected Prostate Cancer Recurrence Post-Prostatectomy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DEVICE: 18F-FCH PET/MRI Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Gemcitabine and Docetaxel in Treating Patients With Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: docetaxel|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Preventive Cognitive Training on Cognitive Impairment After Stroke in Acute Stage
Status: UNKNOWN
Conditions: Stroke, Acute Ischemic|Cognitive Impairment
Interventions: BEHAVIORAL: hierarchical multi-dimensional cognitive training scheme based on computer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Vaginal Misoprostol and Dinoprostone Prior to Copper Intrauterine Device Insertion in Women Delivered Only by Cesarean Delivery
Status: UNKNOWN
Conditions: IUD Pain
Interventions: DRUG: Dinoprostone 3 mg|DRUG: Misoprostol 200Mcg Tab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Cognitive and Cerebral Changes in Sepsis Survivors and Their Predictors
Status: UNKNOWN
Conditions: Severe Sepsis With Septic Shock|Severe Sepsis Without Septic Shock
Interventions: PROCEDURE: Blood Sample|BEHAVIORAL: Neurocognitive Assessment|OTHER: Resting State EEG|PROCEDURE: Lumbar Puncture|OTHER: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Intermittent Compression-decompression With Glides for Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: intermittent compression-decompression with glides|OTHER: Conventional Physical Therapy|OTHER: conventional physical therapy and intermittent compression-decompression with glides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial of Domperidone in Relapsing-Remitting Multiple Sclerosis (RRMS)
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Domperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Label Placebo Study To Assess The Inhalation Profile Obtained By Acoustic Monitoring In COPD Patients Using The NEXThaler DPI
Status: COMPLETED
Conditions: COPD
Interventions: DEVICE: Inhalation through Chiesi NEXThaler DPI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effectiveness of Carpal Ligament Self-myofascial Stretching in Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: OTHER: Carpal ligament self-myofascial stretching|OTHER: Conventional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The COLchicine HEART Failure PRESERVED Trial (COLHEART-PRESERVED)
Status: RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: Colchicine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Drug Interactions Between Single and Concomitant Administrations of Amlodipine, Losartan, and Hydrochlorothiazide in Subjects With (Pre)Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: multiple dose, crossover study between single and concomitant administrations of amlodipine, losartan, and hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Vistakon Investigational Contact Lenses Worn for Daily Wear
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: galyifilcon A control lens|DEVICE: galyfilcon A with a silver additive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Re-directed T Cells for the Treatment (FAP)-Positive Malignant Pleural Mesothelioma
Status: COMPLETED
Conditions: Malignant Pleural Mesothelioma
Interventions: GENETIC: Adoptive Transfer of re-directed T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability and Pharmacokinetics of TCMCB07 in Single and Multiple Ascending Doses in Health Subjects
Status: COMPLETED
Conditions: Cachexia
Interventions: DRUG: TCMCB07|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Beliefs About Mental Health Treatment - Gambling Addiction Study in Colorado
Status: NOT_YET_RECRUITING
Conditions: Gambling Disorder|Gambling Problem|Mental Health Issue
Interventions: BEHAVIORAL: Monetary Incentive for Take-Up of Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: A Study of GZR18 Injection in Chinese Patients With Type 2 Diabetes Mellitus
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: GZR18|DRUG: Semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Different Types of Physical Exercise on Immunosenescence in Elderly Persons
Status: RECRUITING
Conditions: Healthy Aged Volunteers
Interventions: OTHER: Intensive Strength Training (IST)|OTHER: Strength Endurance Training (SET)|OTHER: Flexibility Training (FT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: BASIC_SCIENCE
Clinical trial: A Comparison of Ambu® AuraGain™ Laryngeal Mask Airway and I-gel in Adult
Status: COMPLETED
Conditions: Laryngeal Mask|Intubation; Difficult or Failed
Interventions: DEVICE: Ambu® AuraGain™|DEVICE: I-gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Intravenous Iron to Treat Postoperative Anemia in Older Cardiac Surgery Patients
Status: RECRUITING
Conditions: Iron Deficiency Anemia
Interventions: DRUG: Ferric Derisomaltose 100 MG/ML|DRUG: Sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effects of SLx-2101 Taken for up to 14 Days on Blood Pressure in Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: SLx-2101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Natural Killer/T Cell Lymphoma-Ⅲ/Ⅳ
Status: UNKNOWN
Conditions: Nasal and Nasal-type NK/T-cell Lymphoma
Interventions: DRUG: DDGP(cisplatin,dexamethasone,gemcitabine,pegaspargase)|DRUG: Modified SMILE （MTX，DEX，IFO，L-ASP，Etoposide，Mesna）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enzalutamide Before Surgery in Treating Patients With Kidney Cancer
Status: TERMINATED
Conditions: Clear Cell Renal Cell Carcinoma|Stage I Renal Cell Cancer
Interventions: DRUG: Enzalutamide|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Nephrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrastromal Corneal Ring Segments and Toric Phakic Posterior Intra-ocular Lenses Implantation in Keratoconus
Status: UNKNOWN
Conditions: Keratoconus
Interventions: OTHER: corneal ring segments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Serplulimab and Trastuzuma and Chemotherapy in Her-2+ Gastric Cancer
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Serplulimab|DRUG: Trastuzuma|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AZD9164 Single Ascending Dose Study in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD9164|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Global Study to Assess the Effects of Osimertinib in Participants With EGFRm Stage IA2-IA3 NSCLC Following Complete Tumour Resection
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Osimertinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome
Status: COMPLETED
Conditions: Cushing Syndrome|Endocrine Disease
Interventions: DRUG: Pentetreotide|DRUG: 18F-DOPA|DEVICE: CT scan|DEVICE: MRI|DRUG: 18-FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants With Primary Progressive Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis, Primary Progressive
Interventions: DRUG: Fenebrutinib|DRUG: Ocrelizumab|DRUG: Placebo matched to ocrelizumab|DRUG: Placebo matched to fenebrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MitoQ Treatment of Claudication: Myofiber and Micro-vessel Pathology
Status: RECRUITING
Conditions: Peripheral Arterial Disease
Interventions: DIAGNOSTIC_TEST: Walking assessment|OTHER: QOL Survey|DIAGNOSTIC_TEST: Ankle pressure at rest and after stress|DIAGNOSTIC_TEST: Muscle Oxygen|DIAGNOSTIC_TEST: Serum MitoQ Level|PROCEDURE: Needle Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of OXC XR as Adjunctive Therapy in Subjects With Refractory Partial Epilepsy
Status: COMPLETED
Conditions: Partial Epilepsy
Interventions: DRUG: Oxcarbazepine XR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK/PD of XM22 in Children With Ewing Family of Tumors or Rhabdomyosarcoma
Status: COMPLETED
Conditions: Ewing Family of Tumors, Rhabdomyosarcoma
Interventions: DRUG: Lipegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis
Status: RECRUITING
Conditions: Pain|Pain Syndrome|Pain, Chronic|Chronic Pain|Chronic Pain Syndrome|Neuropathic Pain|Central Neuropathic Pain|Paraplegia|Multiple Sclerosis|Stroke|Phantom Limb Syndrome With Pain|Phantom Pain|Traumatic Brain Injury
Interventions: DRUG: Adezunap|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Clinical Study of Napabucasin (GB201) Plus FOLFIRI in Adult Patients With Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Previously Treated Metastatic Colorectal Cancer
Interventions: DRUG: Napabucasin|DRUG: Fluorouracil|DRUG: Leucovorin|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Implant Placement With Platlet Rich Fibrin as Space Filling Material Versus the Use of Deprotienized Bovine Bone (Tutogen) in Maxillary Premolars.
Status: UNKNOWN
Conditions: Immediate Dental Implant
Interventions: PROCEDURE: deprotienized bovine bone (tutogen)|PROCEDURE: platelet rich fibrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Treatment Efficacy According to Risk Group in Relapsed Childhood Acute Lymphoblastic Leukemia
Status: NOT_YET_RECRUITING
Conditions: Acute Lymphoid Leukemia
Interventions: DRUG: Blincyto
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Assessment of Autonomic Tone in Normotensive Women Using Combined Hormonal Oral Contraceptive Containing Drospirenone
Status: UNKNOWN
Conditions: Contraceptive Affecting the Autonomic Nervous System|Contraceptive Affecting Blood Pressure
Interventions: DRUG: Contraceptives, Oral, Combined (Yaz®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Mechanical Ventilation - Effects on PTSD
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic|Depression|Anxiety
Interventions: OTHER: Non-sedation|OTHER: Control, sedation (propofol, midazolam)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Preliminary Efficacy of Erythrocyte-αPD-1 Conjugate in Patients With Advanced Malignancies
Status: NOT_YET_RECRUITING
Conditions: Cancer|Solid Tumor|Hematologic Malignancy
Interventions: DRUG: Engineered erythrocytes (or red blood cells) covalently conjugated with commercially available anti-PD-1 antibodies on their membranes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Efficacy of Sodium Picosulfate/Magnesium Citrate Versus PEG/Ascorbic Acid in Ulcerative Colitis Patients
Status: UNKNOWN
Conditions: Ulcerative Colitis
Interventions: DRUG: Sodium Picosulfate/Magnesium Citrate Laxative|DRUG: 2L polyethylene glycol/ascorbic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Increase Colorectal Screening
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: BEHAVIORAL: Inreach strategy|BEHAVIORAL: Outreach strategy|BEHAVIORAL: Both Inreach and Outreach strategies|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Randomized, Controlled, Double Blind, to Evaluate the Postpartum Analgesia With Epidural Morphine: Analgesic Effect of Two Different Doses Compared to Placebo
Status: COMPLETED
Conditions: Labor Pain
Interventions: DRUG: Morphine|DRUG: saline solution|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Grip on Knee Osteoarthritis; DIstraction Versus Arthroplasty
Status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Knee Joint Distraction (KD)|PROCEDURE: Knee Prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Tribulus Terrestris in Postmenopausal Women With Hypoactive Sexual Desire Disorder
Status: COMPLETED
Conditions: Menopause|Sexual Abstinence
Interventions: DRUG: Tribulus Terrestris|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sphenopalatine Ganglion Block Versus Occiptal Nerve Block in Treatment of Post Dural Puncture Headache
Status: COMPLETED
Conditions: Headache
Interventions: PROCEDURE: Sphenopalatine block|PROCEDURE: Greater occipital nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Analgesic Effect of the Perineal Infiltration of Ropivacaine 0.75% Versus Placebo in Post-episiotomy Perineal Pain
Status: COMPLETED
Conditions: Episiotomy
Interventions: DRUG: Administration of Ropivacaïne|DRUG: Administration of placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rivastigmine for Antimuscarinic Delirium
Status: NOT_YET_RECRUITING
Conditions: Anticholinergic Toxicity
Interventions: DRUG: Rivastigmine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Correlational and Intervention Effects of Egg Consumption on Macular Carotenoids, Cognition, and Achievement During Childhood
Status: UNKNOWN
Conditions: Diet Habit|Cognitive Control
Interventions: OTHER: Whole Egg Intervention|OTHER: Egg White Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: The HIV Functional Cure Potential of UB-421 in ART Stabilized HIV-1 Patients
Status: NOT_YET_RECRUITING
Conditions: HIV-1-infection
Interventions: BIOLOGICAL: UB-421(25 mg/kg) Q2W|BIOLOGICAL: UB-421(25 mg/kg) Q4W
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pattern of Gene Expression in Adipose Tissue From Patients With Cushing Syndrome
Status: COMPLETED
Conditions: Cushing Syndrome Related to Cortisolic Adenoma
Interventions: OTHER: analyze the role of glucocorticoid in AT distribution.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase I Pharmacokinetics and Safety Study of Two Dapivirine Intravaginal Gels
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Dapivirine Gel 4750, 0.05%, 2.5g|DRUG: Dapivirine Gel 4789, 0.05%, 2.5g|DRUG: HEC-based Placebo Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pain After Root Canal Obturation With Sealer Containing or Not 1% Enoxolone
Status: COMPLETED
Conditions: Root Canal Obturation
Interventions: DEVICE: SEALITE Regular|DEVICE: SEALITE Ultra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mobile Education System to Improve Disease Knowledge, Self-efficacy and Quality of Life in Patients With Heart Failure
Status: RECRUITING
Conditions: Acute Decompensated Heart Failure
Interventions: BEHAVIORAL: accepting the operation process of automated intelligent education software system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Adding Dexamethasone to Intrathecal Bupivacaine on Blood Sugar of Patients Undergoing Diabetic Foot Surgeries
Status: COMPLETED
Conditions: Diabetic Foot
Interventions: DRUG: Bupivacaine with dexamethasone|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Impact of Positron Emission Tomography (PET) Imaging in Women With Locally Advanced Cervical Cancer (PET LACE Trial)
Status: COMPLETED
Conditions: Cervical Cancer|Squamous Cell Carcinoma|Adenosquamous Carcinoma|Adenocarcinoma
Interventions: PROCEDURE: CT Abdomen and Pelvis scan + whole body PET-CT scan|PROCEDURE: CT Abdomen and Pelvis scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Nano-structured Alumina Coating on the Bond Strength of Zirconia Resin-bonded Fixed Dental Prostheses
Status: RECRUITING
Conditions: Missing Incisors|Zirconia Surface Pretreatment|Children|Adults|Debonding
Interventions: OTHER: NAC|OTHER: APA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Gamma-secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced, Metastatic, or Recurrent Triple Negative Invasive Breast Cancer
Status: TERMINATED
Conditions: Estrogen Receptor-negative Breast Cancer|HER2-negative Breast Cancer|Male Breast Cancer|Progesterone Receptor-negative Breast Cancer|Recurrent Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer|Triple-negative Breast Cancer
Interventions: DRUG: gamma-secretase/Notch signalling pathway inhibitor RO4929097|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Patients With Chronic Stroke Regain Living Independence by Daily Energizing With Biophoton Generators
Status: RECRUITING
Conditions: Chronic Stroke
Interventions: DEVICE: Biophoton Energizing Brain and Whole Body
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: User Satisfaction of Customised 3D Printed Ankle-Foot Orthosis in Comparison to Thermoformed Ankle-Foot Orthosis for Patients With Neurological Conditions: A Preliminary Study
Status: COMPLETED
Conditions: Stroke|Spinal Cord Injuries|Nerve Palsy
Interventions: DEVICE: 3D Printed Ankle-Foot Orthosis|DEVICE: Thermoformed Ankle-Foot Orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab Combined With Ipilimumab Versus Sunitinib in Previously Untreated Advanced or Metastatic Renal Cell Carcinoma (CheckMate 214)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Renal Cell Carcinoma|Metastatic Renal Cell Carcinoma
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: Ipilimumab|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SGI-110 Plus Durvalumab/Tremelimumab in SCLC
Status: COMPLETED
Conditions: Extensive-stage Small Cell Lung Cancer
Interventions: DRUG: Durvalumab|DRUG: Tremelimumab|DRUG: SGI-110
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Astaxanthin for Management of Inflammation in Knee Osteoarthritis
Status: TERMINATED
Conditions: Osteoarthritis, Knee|Osteoarthritis Knees Both|Joint Inflammation
Interventions: DRUG: Astaxanthin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study Assessing the Efficacy and Safety of DE-117 Ophthalmic Solution Compared With Timolol Maleate Ophthalmic Solution 0.5% in Subjects With Glaucoma or Ocular Hypertension - Spectrum 3 Study
Status: COMPLETED
Conditions: Glaucoma and Ocular Hypertension
Interventions: DRUG: DE-117 Ophthalmic Solution|DRUG: Timolol Maleate Ophthalmic Solution 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Soft Tissue Expansion in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues
Status: COMPLETED
Conditions: Thyroid Associated Ophthalmopathies
Interventions: DRUG: bimatoprost 0.03%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Telbivudine Treatment at Long Term on the Absence of Liver Inflammation in Patients With Compensated Chronic Hepatitis B
Status: COMPLETED
Conditions: Compensated Chronic Hepatitis B
Interventions: DRUG: telbivudine/LDT600
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VAsopressin and STeroids in Addition to Adrenaline in Cardiac Arrest - a Randomized Clinical Trial
Status: RECRUITING
Conditions: Cardiac Arrest;In-hospital Cardiac Arrest; Methylprednisolone; Vasopressin; Adrenaline; Randomized Clinical Trial
Interventions: DRUG: Vasopressin; Methylprednisolone; Hydrocortisone|DRUG: Sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thorough QT/QTC (TQT) Clinical Trial to Evaluate the Effect of Zoliflodacin on Cardiac Repolarization in Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Electrocardiogram Repolarisation Abnormality|Gonococcal Infection
Interventions: DRUG: AZD0914|DRUG: Moxifloxacin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Exercise and Nutrition Education in Improving Physical Function and Quality of Life in Older Breast Cancer Survivors
Status: TERMINATED
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Cancer Survivor|Inactivity|Obesity|Overweight|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8
Interventions: OTHER: Educational Intervention|BEHAVIORAL: Exercise Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Therapy Compared With Single-Drug Therapy in Patients With Cardiac Diseases
Status: TERMINATED
Conditions: Cardiovascular Diseases|Heart Diseases|Beta-Thalassemia
Interventions: DRUG: Deferoxamine|DRUG: Deferiprone (L1)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Novel Approach to Stimulant Induced Weight Suppression and Its Impact on Growth
Status: COMPLETED
Conditions: ADHD|Growth
Interventions: BEHAVIORAL: behavior therapy|DRUG: Extended release (ER) methylphenidate product|OTHER: monitoring|OTHER: drug holiday|DIETARY_SUPPLEMENT: caloric supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: William Training Versus Hold Relax Stretching of Iliopsoas Muscle
Status: UNKNOWN
Conditions: Hyperlordosis
Interventions: OTHER: HOLD RELAX STRETCHING OF ILIOPSOAS|OTHER: WILLIAM'S PROTOCOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study for Safety and Effectiveness of IMC-A12 by Itself or Combined With Antiestrogens to Treat Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: BIOLOGICAL: IMC-A12 (cixutumumab)|DRUG: tamoxifen|DRUG: Anastrozole|DRUG: Letrozole|DRUG: Exemestane|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Food Study of Quinapril Hydrochloride Tablets 40 mg and Accupril® Tablets 40 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Quinapril Hydrochloride Tablets 40 mg|DRUG: Accupril® Tablets 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate Efficacy and Safety of ASP015K in Patients With Rheumatoid Arthritis (RA) Who Had an Inadequate Response to Methotrexate (MTX) Treatment
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Peficitinib|DRUG: Placebo|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the Bacteriophage Preparation, ShigActive™, in a Human Experimental Model of Shigellosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Shigellosis
Interventions: BIOLOGICAL: bacteriophage|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Liposomal Doxorubicin and Interleukin-12 in Treating Patients With AIDS-Related Kaposi's Sarcoma
Status: COMPLETED
Conditions: Sarcoma
Interventions: BIOLOGICAL: recombinant interleukin-12|DRUG: paclitaxel|DRUG: pegylated liposomal doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Ischemic Preconditioning for Subcortical Vascular Dementia
Status: UNKNOWN
Conditions: Subcortical Vascular Dementia
Interventions: DEVICE: Doctormate® (200mmHg)|DEVICE: Doctormate® (60mmHg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dezoxide Suppresses Sufentanil-induced Cough
Status: UNKNOWN
Conditions: Sufentanil-induced Cough
Interventions: DRUG: Intravenous dizocine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Analysis of Soluble TREM (Triggering Receptor Expressed on Myeloid Cells)-1 and -2 in Crevicular Fluid and Associated Bacterial Flora in Patients Affected by Periodontitis
Status: COMPLETED
Conditions: Periodontitis
Interventions: BIOLOGICAL: Crevicular samples (1-10µl)|BIOLOGICAL: Saliva samples (1ml)|OTHER: Etiologic treatment|OTHER: Psychometric tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial Comparing Niraparib-bevacizumab-Dostarlimab and Niraparib-bevacizumab to Standard of Care in Recurrent Ovarian Cancer
Status: WITHDRAWN
Conditions: Ovarian Cancer
Interventions: DRUG: Niraparib|DRUG: Bevacizumab|DRUG: TSR042|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous HuCART19 T Cells Manufactured Using the CliniMACS Prodigy Platform for Pediatric B-ALL (huCART19 Prodigy)
Status: RECRUITING
Conditions: B Cell Acute Lymphoblastic Leukemia (B-ALL)|B Lineage Lymphoblastic Lymphoma
Interventions: BIOLOGICAL: Autologous Humanized CD19-Directed Chimeric Antigen Receptor T-Cells (huCART19)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Raltegravir Intensification in HIV-infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Raltegravir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT