pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Supplemental Egg Protein Intervention In Older Adults
Status: COMPLETED
Conditions: Sarcopenia|Aging
Interventions: DIETARY_SUPPLEMENT: powdered egg white protein supplement|DIETARY_SUPPLEMENT: maltodextrin supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Dietary Nitrate Supplementation on Ability of Individuals With Type 2 Diabetes to Perform Exercise
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Beetroot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Saphenous Nerve Block vs. Femoral Nerve Block for Total Knee Arthroplasty
Status: COMPLETED
Conditions: Difference Between Femoral Nerve Block and Saphenous Block
Interventions: PROCEDURE: Study Technique|PROCEDURE: Control Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Effectiveness and Safety of Biosimilar and Legacy Drugs
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Ankylosing Spondylitis|Ulcerative Colitis|Crohn's Disease
Interventions: DRUG: Biosimilar|DRUG: Originator (legacy) drug
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect Of Maraviroc On The Pharmacokinetics Of Digoxin
Status: COMPLETED
Conditions: Healthy|HIV Infections
Interventions: DRUG: Digoxin|DRUG: Digoxin|DRUG: Maraviroc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of a Candidate Tuberculosis Vaccine in Healthy Infants
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: GSK's investigational vaccine 692342|BIOLOGICAL: Tritanrix™ HB+Hib|BIOLOGICAL: Prevnar™|BIOLOGICAL: Polio Sabin™|BIOLOGICAL: Menjugate™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Therapeutic Effects and Safety of ALK4290 in Patients With Refractory Wet Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Wet Age-related Macular Degeneration
Interventions: DRUG: ALK4290
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relapsed and/or Refractory Non-Hodgkin Lymphoma Study
Status: WITHDRAWN
Conditions: Non-Hodgkin Lymphoma
Interventions: DRUG: Vorinostat in combination with Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breath-Actuated Nebulizer Versus Conventional Continuous-Output Nebulizer in Pediatric Asthma Patients
Status: TERMINATED
Conditions: Asthma
Interventions: DEVICE: Nebulizer (breath-actuated versus conventional continuous-output)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Inhaled Carbon Monoxide to Treat Acute Respiratory Distress Syndrome (ARDS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Respiratory Distress Syndrome
Interventions: DRUG: Inhaled Carbon Monoxide at 200 ppm|OTHER: Inhaled Medical air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate IMC-002 in Neuromyelitis Optica Spectrum Disorder (NMOSD) Patients
Status: NOT_YET_RECRUITING
Conditions: Neuromyelitis Optica Spectrum Disorder (NMOSD)
Interventions: DRUG: IMC-002|DRUG: mycophenolate mofetil， MMF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Addition of Nitrous Oxide and Its Effects on Depth of Anesthesia
Status: COMPLETED
Conditions: Deep Sedation|Anesthesia, General
Interventions: DRUG: Sevoflurane group|DRUG: Propofol group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study Evaluating Tarlatamab After Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer (LS-SCLC)
Status: RECRUITING
Conditions: Limited Stage Small Cell Lung Cancer|Small Cell Lung Cancer
Interventions: DRUG: Tarlatamab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Geriatric Oncology Screening of Older Patients With Solid Cancers
Status: COMPLETED
Conditions: Solid Carcinoma|Frailty|Age|Geriatrics|Screening|Cancer
Interventions: DIAGNOSTIC_TEST: Geriatric 8|DIAGNOSTIC_TEST: modified Geriatric 8|DIAGNOSTIC_TEST: 30 second chair stand test|DIAGNOSTIC_TEST: Handgrip Strength Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy, Tolerability and Pharmacokinetics of Subcutaneous Exendin (9-39) in Patients With Post Bariatric Hypoglycemia
Status: COMPLETED
Conditions: Post Bariatric Hypoglycemia
Interventions: DRUG: Lyo avexitide|DRUG: Liq avexitide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Traumacel FAM Trium in the Post-market Surveillance Phase
Status: COMPLETED
Conditions: Bleeding|Surgical Wound
Interventions: DEVICE: Traumacel FAM Trium|DEVICE: Surgicel Fibrillar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Trial of 12 Weeks of Treatment With Nebulized SUN-101 in Patients With COPD (GOLDEN-4)
Status: COMPLETED
Conditions: COPD|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: SUN-101 50 mcg BID eFlow (CS) nebulizer|DRUG: SUN-101 25 mcg BID eFlow (CS) nebulizer|DRUG: Placebo eFlow (CS) nebulizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Assess Bioequivalence of Lazertinib Between Two Formulations in Healthy Volunteers.
Status: COMPLETED
Conditions: Healthy Adult Volunteers
Interventions: DRUG: Lazertinib(G001)|DRUG: Lazertinib(G002)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between 7 and 14 Day Primaquine Combined With Dihydroartemisinin-piperaquine or 3 Day Chloroquine Radical Cure of P. Vivax (BPD)
Status: COMPLETED
Conditions: Vivax Malaria
Interventions: DRUG: Dihydroartemisinin-Piperaquine|DRUG: Dihydroartemisinin-Piperaquine|DRUG: Chloroquine|DRUG: Chloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Once Daily Enoxaparin for Outpatient Treatment of Acute DVT and/or Pulmonary Embolism
Status: COMPLETED
Conditions: Deep Vein Thrombosis|Pulmonary Embolism
Interventions: DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Non-interventional Study of Ability and Willingness to Pay for BIAsp 30 in a Real World Population With Type 2 Diabetes Mellitus (T2DM)
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: BIAsp 30
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized Controlled Trial of Virtual Reality Assisted Guided Imagery (VRAGI) for Pain in Advanced Cancer Patients.
Status: UNKNOWN
Conditions: Cancer Pain|Oncology|Virtual Reality|Depression, Anxiety
Interventions: BEHAVIORAL: Virtual Reality Assisted Guided Imagery (VRAGI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Cannabis in the Treatment of Tinnitus Patients
Status: WITHDRAWN
Conditions: Tinnitus
Interventions: DRUG: Cannabis|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sickness Evaluation at Altitude With Acetazolamide at Relative Doses
Status: COMPLETED
Conditions: Acute Mountain Sickness
Interventions: DRUG: Acetazolamide Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Performance and Safety of Ambu® aScope™ 4 Cysto and aView™ Urologia for Flexible Cystoscopy
Status: COMPLETED
Conditions: Cystoscope|Lower Urinary Tract Symptoms|Bladder Disease
Interventions: DEVICE: Flexible cystoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Feasibility of a Novel Process-based Treatment for Patients With Psychosis
Status: COMPLETED
Conditions: Schizophrenia|Schizotypal Disorder|Delusional Disorder|Brief Psychotic Disorder|Shared Psychotic Disorder|Schizoaffective Disorder|Other Psychotic Disorder Not Due to A Substance or Known Physiological Condition|Unspecified Psychosis Not Due to a Substance or Known Physiological Condition|Manic Episode, Severe With Psychotic Symptoms|Bipolar Disorder, Current Episode Manic Severe With Psychotic Features|Bipolar Disorder, Current Episode Depressed, Severe, With Psychotic Features|Major Depressive Disorder, Single Episode, Severe With Psychotic Features|Major Depressive Disorder, Recurrent, Severe With Psychotic Symptoms
Interventions: BEHAVIORAL: Metacognitive and Defusion Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Height Changes In Three Implants Retained Mandibular Overdenture
Status: COMPLETED
Conditions: Bone Loss|Implant Site Reaction
Interventions: OTHER: ball attachment to retain mandibular over denture|OTHER: locator attachment to retain mandibular over denture|OTHER: telescopic attachment to retain mandibular over denture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of Brolucizumab 6 mg Drug Product Intended for Commercialization in Patients With nAMD
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: Brolucizumab 6 mg|DRUG: Aflibercept 2 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Predicting RadIotherapy ReSponse of Rectal Cancer With MRI and PET
Status: COMPLETED
Conditions: Rectal Neoplasms
Interventions: OTHER: Early MRI and PET/CT - 2 weeks after commencing chemo/RT|OTHER: Late MRI and PET/CT 6 weeks post chemo/RT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Combination Therapy With Imiquimod Cream 5% and Tazarotene Cream 0.1% for the Treatment of Lentigo Maligna
Status: COMPLETED
Conditions: Cancer|Lentigo Maligna
Interventions: DRUG: Imiquimod Cream|DRUG: Tazarotene Cream 0.1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Continuous Versus Single Dose Spinal Anesthesia in Octagenerians Undergoing Hip Surgery
Status: UNKNOWN
Conditions: Octagenerian Population Undergoing Hip Surgeries
Interventions: PROCEDURE: Continous Spinal Anestheisa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluate the Pharmacokinetics and Safety of DWP14012 Tablet A and Compare Those of DWP14012 Tablet B in Healthy Subjects
Status: COMPLETED
Conditions: Phase 1 Study, Healthy Volunteers
Interventions: DRUG: DWP14012 Tablet A|DRUG: DWP14012 Tablet B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Non-pharmacological Interventions on Pain Levels, Crying Times and Voice Decibels in Newborns
Status: UNKNOWN
Conditions: Newborn
Interventions: OTHER: kangaroo care|OTHER: holding on the mother's lap|OTHER: white noise listening|OTHER: ambient sound listening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Individualized vs Low PEEP in One Lung Ventilation
Status: WITHDRAWN
Conditions: One-Lung Ventilation|Obesity|Lung Diseases
Interventions: PROCEDURE: One-lung ventilation with individualized PEEP|PROCEDURE: One-lung ventilation with low PEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial of R-GemOx Versus R-miniCHOP Regimen in First-line Treatment of Elderly Diffuse Large B Cell Lymphoma
Status: UNKNOWN
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: Rituximab|DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Cyclophosphamide|DRUG: Epirubicin Injectable Product|DRUG: Vindesine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ciprofol vs Propofol for Reducing Hypoxia Incidence in ERCP
Status: NOT_YET_RECRUITING
Conditions: Anesthesia; Adverse Effect|Biliary Tract Diseases
Interventions: DRUG: Propofol|DRUG: Ciprofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Blacks and Exacerbations on Long Acting Beta Agonists (LABA) vs. Tiotropium (BELT)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Tiotropium|DRUG: Salmeterol|DRUG: Formoterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of Infrared LED Photobiomodulation in Children With Sleep Bruxism
Status: UNKNOWN
Conditions: Bruxism, Sleep
Interventions: RADIATION: Infrared LED photobiomodulation|DEVICE: Occlusal splint|RADIATION: Placebo LED photobiomodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Immediate Versus Extended Release Tacrolimus; Reducing Calcineurin Inhibitor Related Toxicity in Lung Transplantation Patients
Status: RECRUITING
Conditions: Lung Transplant; Complications
Interventions: DRUG: Extended release tacrolimus|DRUG: Immediate release tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Purified Vero Rabies Vaccine, Serum Free With Human Diploid Cell Vaccine in Pre-exposure Use
Status: COMPLETED
Conditions: Rabies
Interventions: BIOLOGICAL: Purified Vero Rabies Vaccine (VRVg) - Serum Free|BIOLOGICAL: Imovax® Rabies: inactivated rabies vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Measurement-Based Care Vs. Standard Care for Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Measurement Based Care (MBC)|DRUG: Control/Standard-care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bridging the Gap: Creating a Continuum of Care
Status: NOT_YET_RECRUITING
Conditions: Frailty|Dependence|Integrated Care
Interventions: OTHER: Intervention group Case Manager (CM)|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A 21-Day Topical Safety Study of Diltiazem Hydrochloride Using a Cumulative Irritant Patch Test Design
Status: UNKNOWN
Conditions: Skin Irritation
Interventions: DRUG: Diltiazem Hydrochloride 2% Cream|DRUG: Vehicle Cream|DRUG: 0.1% solution o sodium lauryl sulfate (SLS)|DRUG: Saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity Study of Insulin Glargine Ezelin vs Lantus in Type 2 Diabetes Mellitus Patients
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Insulin Glargine Ezelin|DRUG: Insulin Glargine Pen Injector [Lantus]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ketogenic Diet for Refractory Status Epilepticus
Status: COMPLETED
Conditions: Status Epilepticus|Seizure|Epilepsy|Refractory Status Epilepticus|Medically Resistant Status Epilepticus
Interventions: DIETARY_SUPPLEMENT: Ketogenic diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial Evaluating the Safety and Efficacy of the KLOX Biophotonic System in Moderate to Severe Acne
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DEVICE: KLOX Biophotonic System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-Hep B Antibodies at Age 9 to 10 Years After Hep B Vaccine at Birth and DTaP-IPV-Hep B-PRP-T Hexavalent Vaccine.
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Euvax B®: Hepatitis B vaccine|BIOLOGICAL: Euvax B®: Hepatitis B vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Abiraterone Acetate Plus Prednisone With or Without Exemestane in Postmenopausal Women With Estrogen Receptor-Positive (ER+) Metastatic Breast Cancer Progressing After Letrozole or Anastrozole Therapy
Status: COMPLETED
Conditions: Metastatic ER+ Her2- Breast Cancer|Postmenopausal
Interventions: DRUG: Exemestane|DRUG: Abiraterone acetate + Prednisone/ Prednisolone + Exemestane|DRUG: Abiraterone acetate + Prednisone or Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypertonic Saline Injection For Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Stress Incontinence
Interventions: PROCEDURE: Periurethral injection|DRUG: Hypertonic (10%) saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of Ondansetron 24 mg Orally Disintegrating Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ondansetron|DRUG: Zofran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose:
Clinical trial: A Randomized, Double-Blind, Placebo-Controlled Pilot Study of Sublingual/Oral Immunotherapy for the Treatment of Peanut Allergy
Status: COMPLETED
Conditions: Peanut Hypersensitivity|Food Hypersensitivity|Immediate Hypersensitivity
Interventions: DRUG: Peanut powder|DRUG: Peanut extract|DRUG: Placebo extract|DRUG: Placebo powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of an Immersive Virtual Reality Based Biofeedback Intervention for Outpatients in Rheumatology
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Systemic Lupus Erythematosus|Spondyloarthropathy|Vasculitis
Interventions: DEVICE: VR-Biofeedback
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy Study of the Effect of Budesonide on Emphysema
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Pulmicort (budesonide) Turbuhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Intra-articular Pulsed Radiofrequency in Chronic Knee Pain
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Osteoarthritis|Pain, Chronic
Interventions: PROCEDURE: Intra-articular Pulsed Radiofrequency|DRUG: Steroid Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Adipose-Derived Stromal Vascular Fraction Cells for Osteoarthritis Treatment
Status: COMPLETED
Conditions: Osteoarthritis|Joint Disease|Osteoarthritis,Knee|Arthritis, Degenerative|Osteoarthrosis|Osteoarthrosis Deformans
Interventions: PROCEDURE: Intra-articular auto-SVFs injection|DRUG: Hyaluronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NORSPAN Transdermal Patches Phase III Study In Non-Cancer Pain
Status: COMPLETED
Conditions: Disease (or Disorder); Intervertebral Disc, With Myelopathy (Manifestation)
Interventions: DRUG: Buprenorphine Transdermal System|DRUG: Buprenorphine Transdermal System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Transcranial Direct Current Stimulation (tDCS) and Motor Learning in Children With Cerebral Palsy (CP)
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DEVICE: Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SSAT063- Pharmacokinetics of Efavirenz 400 mg Once Daily During Pregnancy in HIV-1 Infected Women
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Efavirenz|DRUG: tenofovir /emtricitabine|DRUG: tenofovir/lamivudine|DRUG: lamivudine/zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate a HIV Drug for the Treatment of HIV Infection
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus|HIV Infections
Interventions: DRUG: BMS-955176|DRUG: Placebo matching with BMS-955176|DRUG: Atazanavir|DRUG: Ritonavir|DRUG: Tenofovir|DRUG: Emtricitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2
Status: ENROLLING_BY_INVITATION
Conditions: Systemic Inflammation|Neuroinflammation|Microvascular Thrombosis
Interventions: DRUG: IV normal saline|DRUG: IV immunoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Palonosetron and Hydroxyzine to Reduce Opioid Withdrawal
Status: COMPLETED
Conditions: Substance-Related Disorders
Interventions: DRUG: Palonosetron|DRUG: Hydroxyzine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of ChAd63 RH5 and MVA RH5 in Adults, Young Children and Infants Living in Tanzania
Status: COMPLETED
Conditions: Malaria,Falciparum
Interventions: BIOLOGICAL: ChAd63 RH5|BIOLOGICAL: MVA RH5|BIOLOGICAL: Rabies Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of Matrilin-3 Pretreated Autologous Adipose Derived Mesenchymal Stem Cells Implantation in Chronic Low Back Pain Patients With Lumbar Intervertebral Disc Degeneration
Status: UNKNOWN
Conditions: Patients With Chronic Low Back Pain Due to Degenerative Lumbar Disc
Interventions: BIOLOGICAL: administered an autologous adipose-derived mesenchymal stem cell spheroid pretreated with matrillin 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Astrocytic Markers and the Pre-ataxic Period of SCA3/MJD - BIGPRO Study Astrocytes
Status: UNKNOWN
Conditions: Spinocerebellar Ataxia Type 3|Machado-Joseph Disease|SCA3|MJD
Interventions: DIAGNOSTIC_TEST: Molecular Diagnosis|DIAGNOSTIC_TEST: Clinical Scales - Baseline|DIAGNOSTIC_TEST: Blood Draw - Baseline|DIAGNOSTIC_TEST: Quality of Life Assessment - Baseline|DIAGNOSTIC_TEST: Clinical Scales - Follow-up 12 months|DIAGNOSTIC_TEST: Blood Draw - Follow-up 12 months|DIAGNOSTIC_TEST: Quality of Life Assessment - Follow-up 12 months|DIAGNOSTIC_TEST: Clinical Scales - Follow-up 24 months|DIAGNOSTIC_TEST: Blood Draw - Follow-up 24 months|DIAGNOSTIC_TEST: Quality of Life Assessment - Follow-up 24 months
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Postprandial Metabolic Response After Use of Glucerna SR in Obese Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes|Obesity
Interventions: DIETARY_SUPPLEMENT: Glucerna SR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pragmatic Comparative Effectiveness Trial of Evidence-based, On-demand, Digital Behavioral Treatments for Chronic Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Pain
Interventions: BEHAVIORAL: painTRAINER®|DEVICE: PICO G2 4k
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Pharmacokinetics of Mepolizumab as a Liquid Drug in a Safety Syringe or an Autoinjector Versus Lyophilised Drug
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: Lyophilized mepolizumab|BIOLOGICAL: Liquid mepolizumab|DEVICE: Prefilled autoinjector|DEVICE: Prefilled Safety Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2b Dose Finding Study of RMC-035 in Participants Undergoing Open-chest Cardiac Surgery
Status: RECRUITING
Conditions: Kidney Injury Following Open-Chest Cardiac Surgery
Interventions: DRUG: RMC-035|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Chidamide for Advanced Cephalic and Cervical Adenocystic Carcinoma: Evaluation of Efficiency and Safety
Status: UNKNOWN
Conditions: Adenocystic Carcinoma
Interventions: DRUG: Chidamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alemtuzumab in Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIPD)
Status: WITHDRAWN
Conditions: Chronic Inflammatory Demyelinating Neuropathy
Interventions: DRUG: Alemtuzumab infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Motivational Interviewing in Children With Type 1 Diabetes
Status: COMPLETED
Conditions: Motivational Interviewing|Type 1 Diabetes|Hypoglycemia|Fatigue|Self-Compassion
Interventions: BEHAVIORAL: motivational interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Abdominal Pain Management and Point-of-care Ultrasound in the Emergency Department
Status: COMPLETED
Conditions: Abdominal Pain
Interventions: DIAGNOSTIC_TEST: point-of-care ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Sodium Tungstate in Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Sodium Tungstate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First-in-human Study of CA102N Monotherapy and CA102N Combined With Trifluridine/Tipiracil (LONSURF) in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced or Metastatic Solid Tumors|Advanced or Metastatic Colorectal Cancer (mCRC)
Interventions: DRUG: CA102N|DRUG: LONSURF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Splint Usage in Laterognathic Cl III Orthognathic Surgery Patients
Status: UNKNOWN
Conditions: Skeletal Malocclusion|Class III Malocclusion|Laterognathia
Interventions: DEVICE: Oclusal Splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Bioavailability and Metabolism of Avenanthramide: a Novel Oat Phytochemical
Status: COMPLETED
Conditions: Bioavailability|Metabolism|Avenanthramides
Interventions: OTHER: Avenanthramides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Propranolol's Effect on Pain and Inflammation.
Status: COMPLETED
Conditions: Pain Measurement
Interventions: DRUG: Alfentanil|DRUG: Propranolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluaing the Effects of Electroacupuncture for Postoperative Pain Relief in Patients With Distal Radius Fracture
Status: UNKNOWN
Conditions: Postoperative Pain Relief
Interventions: OTHER: electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Behavioral and Neural Response to Memantine in Adolescents With Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Memantine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is PECS Block Equivalent to Paravertebral Block in Preventing Postoperative Pain After Breast Surgery?
Status: COMPLETED
Conditions: Other Acute Postoperative Pain
Interventions: PROCEDURE: PECS block with ropivacaine|PROCEDURE: Paravertebral block with ropivacaine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Cadonilimab in Non-squamous Non-small Cell Lung Cancer Patients Resistant to EGFR-TKI
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Cadonilimab plus Pemetrexed and Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Integration Success and Crestal Bone Preservation Biomet 3i's T3 Implant System
Status: COMPLETED
Conditions: Partial Edentulism|Tooth Disease
Interventions: DEVICE: T3 with DCD tapered Prevail implant|DEVICE: Nanotite Certain tapered implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Biphasic Insulin Aspart 70/30, 50/50, and 30/70 in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementing Exercise Into Clinical Practice in Breast Cancer Care
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: Self-Management|BEHAVIORAL: Booster Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety of Lymph Node Injection for Allergen Immunotherapy
Status: UNKNOWN
Conditions: Allergic Rhinitis
Interventions: BIOLOGICAL: Grass pollen extract|OTHER: Placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DIVA Study - A Study of Different Regimens of Intravenous Administration of Bonviva (Ibandronate) in Women With Post-Menopausal Osteoporosis
Status: COMPLETED
Conditions: Post Menopausal Osteoporosis
Interventions: DRUG: ibandronate [Bonviva/Boniva]|DRUG: ibandronate [Bonviva/Boniva]|DRUG: ibandronate [Bonviva/Boniva]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Induction Therapy With Panitumumab + mFOLFOX-6 in Rectal Cancer and Quadruple Wild-type Mutation Before Surgery
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DRUG: Panitumumab|DRUG: 5Fluorouracil|DRUG: Oxaliplatin|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D and Vitamin B12 Supplementation With Pegylated Interferon-Alfa Plus Ribavirin for Treating Chronic Hepatitis C
Status: TERMINATED
Conditions: RNA Virus Infections|Flaviviridae Infections|Hepatitis C|Hepatitis C, Chronic
Interventions: DRUG: Vitamin D|DRUG: Vitamin B 12
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Colesevelam in Pediatric Patients With Genetic High Cholesterol
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: colesevelam HCl|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of a Diagnostic Score for Encephalitis to Assess the Risk of Autoimmune Origin
Status: ACTIVE_NOT_RECRUITING
Conditions: Autoimmune Encephalitis|Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody (Disorder)
Interventions: OTHER: Clinical score of Granillo and al.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial to Compare the Safety, Tolerability, Immunogenicity and Efficacy of Three Dose Levels of a Liquid Formulation of Influenza Virus Vaccine, (CAIV-T) in Healthy Children
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: CAIV-T, Liquid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Influence of Breast Milk Smell on Newborns Bilirubin Level, Duration of Time Phototherapy and Comfort in Newborns Receiving Phototherapyv
Status: COMPLETED
Conditions: Newborn Jaundice
Interventions: OTHER: breast milk smell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Improved Successful Retrieval Rate of HydroMARK Plus Breast Biopsy Site Marker in Comparison to HydroMARK as Well as Improved Surgeon Satisfaction
Status: NOT_YET_RECRUITING
Conditions: Breast Neoplasm
Interventions: DEVICE: HydroMARK Plus Clip
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Investigate the Effects of Single Intravenous Doses of Difelikefalin (CR845) on the QTc Interval in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CR845 0.5 mcg/kg IV|DRUG: CR845 3 mcg/kg IV|DRUG: Moxifloxacin 400 mg Oral Tablet|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Switching to a Fixed Dose Combination of Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) in HIV-1 Infected Marginalized Populations Who Are Virologically Suppressed
Status: UNKNOWN
Conditions: Human Immunodeficiency Virus I Infection|Drug Use
Interventions: DRUG: Bictegravir/emtricitabine/tenofovir alafenamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Protective Manual Hyperinflation in Acute Mechanically Ventilated Trauma Patients
Status: UNKNOWN
Conditions: Critically Injured Mechanically Ventilated Trauma Patients
Interventions: OTHER: Protective manual hyperinflation|OTHER: Usual method of MHI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Short-term Oxygen During CPET in Pulmonary Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension|Chronic Cardiorespiratory Disease
Interventions: PROCEDURE: Supplemental oxygen via a mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Improving Work Flow Through Cognitive Ergonomics. An Intervention Study
Status: COMPLETED
Conditions: Ergonomics
Interventions: BEHAVIORAL: CE - Cognitive Ergonomics (KERGO)|BEHAVIORAL: RS - Recovery Support (KUORMA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intellectual Enrichment to Build Cognitive Reserve in MS
Status: COMPLETED
Conditions: Cognitive Impairment in Multiple Sclerosis
Interventions: BEHAVIORAL: Intellectual Enrichment daily activities|BEHAVIORAL: Intellectual Enrichment documentary videos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Clinical Trial of Trauma-Focused Cognitive-Behavioral Therapy for Treatment of Post-traumatic Stress in Adults.
Status: NOT_YET_RECRUITING
Conditions: Post Traumatic Stress Disorder|Complex Post-Traumatic Stress Disorder
Interventions: BEHAVIORAL: Trauma-Focused Cognitive Behavioral Therapy for complex presentation (TF-CBT-CP)|OTHER: TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of PF-06651600 on the Pharmacokinetics of Oral Contraceptive Steroids
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06651600|DRUG: Ethinyl estradiol (EE) and levonorgestrel(LN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 1/2a Study of ICT01 Plus Low Dose SC IL-2 in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor, Adult
Interventions: DRUG: ICT01|DRUG: Proleukin Injectable Product|DRUG: Pembrolizumab injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy of House Dust Mite Immunotherapy in Children With Bronchial Asthma
Status: UNKNOWN
Conditions: Asthma
Interventions: BIOLOGICAL: Novo Helisen Depot, Phostal
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apatinib Plus Etoposide Versus Etoposide Alone for Platinum-resistant Recurrent Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: DRUG: Apatinib|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Tuspetinib (HM43239) in Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Leukemia, Myeloid, Acute|Refractory AML|Relapsed Adult AML|Myelodysplastic Syndrome With Excess Blasts-2|Chronic Myelomonocytic Leukemia
Interventions: DRUG: Tuspetinib|DRUG: Venetoclax Oral Tablet|DRUG: Azacitidine for Intravenous Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRECISE (PERFUSION IMAGING TO IDENTIFY POSTERIOR CIRCULATION CANDIDATES FOR THROMBECTOMY)
Status: ACTIVE_NOT_RECRUITING
Conditions: Posterior Circulation Acute Ischemic Stroke Due to Large Vessel Occlusion of the Vertebral or Basilar Artery Needing Endovascular Thrombectomy
Interventions: PROCEDURE: Thrombectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Management of Pain in Persons With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Pain
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy (CBT) +Hypnosis (HYP)|BEHAVIORAL: Cognitive Behavioral Therapy (CBT)|BEHAVIORAL: Self-Hypnosis Training (HYP)|BEHAVIORAL: Education Control (CONT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decitabine and Vaccine Therapy for Patients With Relapsed AML Following Allogeneic Stem Cell Transplantation
Status: WITHDRAWN
Conditions: Acute Myelogenous Leukemia
Interventions: BIOLOGICAL: Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin Plus Insulin on Non-obese Autoimmune Diabetes
Status: UNKNOWN
Conditions: Type 1 Diabetes Mellitus|Autoimmune Diabetes
Interventions: DRUG: Metformin|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CXL-04 A Study of Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas
Status: TERMINATED
Conditions: Keratoconus
Interventions: OTHER: Theralight crosslinking and Riboflavin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Probiotic Intervention to Prevent Relapse Following Hospitalization for Mania
Status: RECRUITING
Conditions: Mania (Neurotic)
Interventions: COMBINATION_PRODUCT: Probio-Tec BG-VCap-6.5|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study for Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01) Booster Immunization
Status: UNKNOWN
Conditions: COVID-19 Pandemic
Interventions: BIOLOGICAL: Recombinant SARS-CoV-2 Fusion Protein Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nitrite Supplementation in Long COVID Patients
Status: RECRUITING
Conditions: Long COVID|Cardiorespiratory Fitness
Interventions: DIETARY_SUPPLEMENT: 210 ml per day of Beet-It nitrate beverage (James White Drinks Ltd., Ipswich, UK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Tolerability and Pharmacokinetics of Oral Doses of SAR442168 With a Food Effect Investigation in Healthy Adult Participants
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Tolebrutinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT