pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluating Simplified Layered Consent for Clinical Trials
Status: RECRUITING
Conditions: Staphylococcus Aureus Bacteremia
Interventions: OTHER: Simplified layered consent form|OTHER: Full-length consent form
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Nurse-led Smoking Cessation Program With Follow-up in Healthy Life Centres: a Randomized Clinical Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Smoking Cessation|Smoking Behaviors|Nurse's Role|Cardiovascular Diseases
Interventions: BEHAVIORAL: Nuse-led interview and referral to municipal healthy life-centres
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Identifying At-Risk Patients and Predicting Deterioration of In-Patients Using Continuous Heart Rate, Respiratory Rate, and Movement Monitoring
Status: COMPLETED
Conditions: Sleep Quality
Interventions: BEHAVIORAL: Risk Stratification|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combination of Anti-CD137 & Ipilimumab in Patients With Melanoma
Status: WITHDRAWN
Conditions: Melanoma
Interventions: DRUG: AntiCD137|DRUG: AntiCD137|DRUG: AntiCD137|DRUG: AntiCD137|DRUG: AntiCD137|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GAD-Alum (Diamyd) Administered Into Lymph Nodes in Combination With Vitamin D in Type 1 Diabetes (DIAGNODE-1)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: GAD-Alum|DRUG: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to See if Tolvaptan Can Delay Dialysis in Infants and Children Who at Enrollment Are 28 Days to Less Than 12 Weeks Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)
Status: RECRUITING
Conditions: Autosomal Recessive Polycystic Kidney Disease (ARPKD)
Interventions: DRUG: Tolvaptan (OPC-41061)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of 9cUAB30 in Healthy Participants
Status: COMPLETED
Conditions: No Evidence of Disease
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Retinoid 9cUAB30
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Continuous Wound Infusion Analgesia in Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Total Knee Arthroplasty
Interventions: DEVICE: On-Q PainBuster with Bupivacaine|DEVICE: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of LIVERFASt Test Compared w/ Liver Biopsy in Patients w/ NAFLD.
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease|Non-Alcoholic Steatohepatitis|Liver Fibroses|Liver Inflammation|Liver Steatoses
Interventions: DIAGNOSTIC_TEST: LIVERFASt
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bio-feedback Treatment for Dysphagic Post-stroke Patients
Status: COMPLETED
Conditions: Dysphagia, Late Effect of Stroke|Deglutition Disorders
Interventions: DEVICE: "ProComp5 Infiniti" Biofeedback|OTHER: Standard Speech and Language Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nursing Intervention in Two Risk Factors of the Metabolic Syndrome and Quality of Life in the Climacteric Period
Status: COMPLETED
Conditions: Obesity, Abdominal|Hypertension|Quality of Life|Menopause
Interventions: BEHAVIORAL: : Nursing intervention in two risk factors of the Metabolic Syndrome, abdominal obesity and arterial hypertension and quality of life in the climacteric period.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Insulin NPH Compared to a New Insulin Formulation in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin NPH|DRUG: EX1000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hibiscus Sabdariffa and Centella Asiatica in the Treatment of Anemia by Iron Deficiency
Status: COMPLETED
Conditions: Iron Deficiency Anemia
Interventions: DRUG: Herbal medicine|DRUG: Iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation for Eradication of Carbapenem-resistant Enterobacteriaceae Colonization
Status: WITHDRAWN
Conditions: Antibiotic Resistant Strain|Microbial Colonization
Interventions: OTHER: Fecal Microbiota Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: To Determine if Olanzapine is More Cost Effective Than Haloperidol for the Treatment of Schizophrenia
Status: COMPLETED
Conditions: Schizoaffective Disorder|Schizophrenia
Interventions: DRUG: Haloperidol|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose:
Clinical trial: Feasibility Study of "My Tools 4 Care-In Care" for Family Caregivers of Residential-Living Older Persons With Dementia
Status: COMPLETED
Conditions: Dementia|Family
Interventions: BEHAVIORAL: My Tools 4 Care - In Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Integrated Therapy of rTMS and rPMS on Upper Limb Function in Patients With Stroke
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: rTMS+rPMS_iTBS_R|DEVICE: rTMS+rPMS_cTBS_R|DEVICE: rTMS +sham-rPMS|DEVICE: rTMS+rPMS_iTBS_M/U|DEVICE: rTMS+rPMS_cTBS_M/U|DEVICE: sham-rTMS+sham-rPMS|DEVICE: rTMS + optimal-rPMS|DEVICE: sham-rTMS+optimal-rPMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Clinical and Medico-economic Impact of SinnoTest® in Patients With Rheumatoid Arthritis
Status: WITHDRAWN
Conditions: Arthritis, Rheumatoid|Biological Therapy
Interventions: DIAGNOSTIC_TEST: Biotherapy Prescription with SinnoTest® software|DRUG: Patient Current Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of a Toolkit to Improve Cardiovascular Disease Screening and Treatment for People With Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus|Cardiovascular Disease
Interventions: OTHER: Toolkit|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: LY2439821|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety & Efficacy of Three Docetaxel-Based Chemotherapy Regimens Plus Bevacizumab With or Without Trastuzumab for Adjuvant Treatment of Patients With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Doxorubicin and cyclophosphamide (AC) + bevacizumab|DRUG: Docetaxel (T) + bevacizumab|DRUG: Docetaxel, doxorubicin, cyclophosphamide (TAC) + bevacizumab|DRUG: Docetaxel, carboplatin, trastuzumab (TCH) + bevacizumab|DRUG: Bevacizumab and trastuzumab maintenance therapy|DRUG: Bevacizumab maintenance therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MLN4924 Compared With MLN4924 Plus Chemotherapy for Large B-cell Lymphoma
Status: WITHDRAWN
Conditions: Lymphoma, Diffuse Large-Cell B-cell|Diffuse, Large B-cell Lymphoma|Lymphoma, Diffuse Large-Cell|Large-Cell Lymphoma, Diffuse
Interventions: DRUG: MLN4924|DRUG: Etoposide|DRUG: Prednisone|DRUG: Vincristine|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Rituximab|DRUG: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dexmedetomidine on Microcirculation in Severe Sepsis
Status: TERMINATED
Conditions: Severe Sepsis
Interventions: DRUG: Dexmedetomidine|DRUG: Midazolam|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluating Family & Community-Based Interventions to Improve Treatment Adherence in Metabolic Health Among Negev Bedouins (EFIT-BED)
Status: NOT_YET_RECRUITING
Conditions: Community-Based Participatory Research
Interventions: BEHAVIORAL: Healthy lifestyle nutrition, culture and physical activity workshops|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Glucose Monitoring in Treatment of Postprandial Hypoglycemia After Bariatric Surgery
Status: RECRUITING
Conditions: Hypoglycemia Non-Diabetic|Bariatric Surgery Candidate
Interventions: DEVICE: Continuous glucose monitor (Dexcom® G7)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Aerobe Interval Training and Moderate Continuous Training in Chronic Obstructive Pulmonary Disease Patients
Status: COMPLETED
Conditions: COPD|Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: 8 Week Study to Evaluate and Compare the Efficacy and Tolerability of MAXCLARITY II and MURAD To Treat Acne
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: OTHER: MAXCLARITY II (2.5% BPO) Foam Cleanser|OTHER: MAXCLARITY II (2.5% BPO) Foam Treatment|OTHER: MAXCLARITY II (0.5% Salicylic Acid) Toner Foam|OTHER: MURAD Clarifying Cleanser (1.5% SA)|OTHER: Exfoliating Acne Treatment Gel (1% SA)|OTHER: Skin Perfecting Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Statin Therapy on Disease Progression in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Status: COMPLETED
Conditions: Polycystic Kidney, Autosomal Dominant
Interventions: DRUG: pravastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Kinesio Tex Tape in Reducing Edema and Seroma After Complex Reconstructive Breast Surgery
Status: UNKNOWN
Conditions: Breast Cancer|Mastectomy|Breast Implantation|Edema|Seroma
Interventions: DEVICE: Kinesio tape lymphatic drainage technique application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sensory Integration Therapy in Autism: Mechanisms and Effectiveness
Status: COMPLETED
Conditions: Autism
Interventions: BEHAVIORAL: Sensory Integration Therapy|BEHAVIORAL: Applied Behavioral Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-Mastectomy Analgesia Using Exparel (Liposomal) Versus Standard Bupivacaine or Placebo
Status: UNKNOWN
Conditions: Mastectomy|Breast Cancer
Interventions: DRUG: Liposomal bupivacaine|DRUG: Standard bupivacaine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of SCH 497079 on Metabolic Parameters and Influence of Race/Ethnic Origin on Therapeutic Response (Study P05338)(COMPLETED)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: SCH 497079|DRUG: Placebo|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Trial of Elobixibat in Patients With Chronic Idiopathic Constipation
Status: TERMINATED
Conditions: Chronic Idiopathic Constipation
Interventions: DRUG: Elobixibat 10 mg/day|DRUG: Elobixibat 5 mg/day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biosimilarity Study of Subcutaneous Pegfilgrastim in Healthy Volunteers
Status: COMPLETED
Conditions: Neutropenia
Interventions: BIOLOGICAL: Pegfilgastrim Megalabs|BIOLOGICAL: Pegfilgastim Amgen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Dose Study Investigating the Absorption and Elimination as Well as the Tolerability of Varenicline Transdermal Delivery System (e.g., a Patch) as Compared to Oral Varenicline in Adult Smokers.
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: varenicline tartrate|DRUG: varenicline free base
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Study on Susceptibility Genes and Pathogenic Mechanism of Non-syndromic Familial Aortic Dissection
Status: UNKNOWN
Conditions: Aortic Dissection|Family Research|Aortic Dissection, Familial, With or Without Aortic Aneurysm
Interventions: GENETIC: movement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy (Induction of Response/Remission) and Safety Study in Patients With Moderate to Severe Crohn's Disease
Status: TERMINATED
Conditions: Crohn Disease
Interventions: DRUG: Sargramostim (Leukine)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Combined Effect of Vedolizumab and Semi-Vegetarian Diet on Ulcerative Colitis.
Status: WITHDRAWN
Conditions: Ulcerative Colitis|Dietary Modification
Interventions: DIETARY_SUPPLEMENT: semi-vegetarian diet|DRUG: Vedolizumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Cultured Corneal Epithelium (CECA) for the Treatment of Limbal Stem Cell Deficiency
Status: RECRUITING
Conditions: Limbal Stem Cell Deficiency
Interventions: PROCEDURE: Surgical transplantation of ACCE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Measles, Mumps, Rubella Vaccination in Juvenile Idiopathic Arthritis
Status: COMPLETED
Conditions: Arthritis, Juvenile Rheumatoid
Interventions: BIOLOGICAL: Measles, Mumps, Rubella vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Standard Endoscopic Hemostasis Versus OVESCO Severe Non-variceal UGI Hemorrhage
Status: RECRUITING
Conditions: Upper Gastrointestinal Hemorrhage
Interventions: DEVICE: Over-the-scope hemoclipping device|OTHER: Standard endoscopic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Vascular CalcIfiCation and sTiffness Induced by ORal antIcoAgulation
Status: COMPLETED
Conditions: Permanent Atrial Fibrillation|Venous Thrombosis|Pulmonary Embolism|Anticoagulation Treatment at Least > or = to 12-month
Interventions: DRUG: Rivaroxaban|DRUG: Fluindione|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pea Hull Fiber - Phase 2
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Pea Fiber|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacokinetic/Pharmacodynamic of Albinterferon Alfa-2b in Chronic Hepatitis B, eAg+, Infection Subjects
Status: TERMINATED
Conditions: Chronic Hepatitis B
Interventions: DRUG: albinterferon alfa-2b|DRUG: albinterferon alfa-2b|DRUG: albinterferon alfa-2b|DRUG: albinterferon alfa-2b|DRUG: Pegasys®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study to Evaluate the Diagnostic Performance of 89Zirconium Girentuximab PET in Urothelial Cancer Patients
Status: COMPLETED
Conditions: Urothelial Carcinoma
Interventions: DRUG: 89Zr-Girentuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Influence of Light on Sleep, Awakening, Electroencephalogram (EEG) and Cognitive Performances
Status: COMPLETED
Conditions: Human Sleep and Chronobiology
Interventions: OTHER: Application of white polychromatic light for 2h30 at different times of day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: CFAE/Spatiotemporal Dispersion Guided Ablation Versus PVI Guided Ablation in Persistent AF
Status: RECRUITING
Conditions: Chronic Atrial Fibrillation
Interventions: PROCEDURE: CFAE guided ablation|PROCEDURE: PVI guided ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Precise Neoadjuvant Chemoresection of Low Grade NMIBC
Status: NOT_YET_RECRUITING
Conditions: Bladder Cancer|Non-muscle Invasive Bladder Cancer|Low-risk
Interventions: DRUG: Epirubicin|DRUG: Mitomycin|DRUG: Gemcitabine|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1b Study of CAR2Anti-CEA CAR-T Cell Hepatic Infusions for Pancreatic Carcinoma Patients With CEA+ Liver Metastases
Status: TERMINATED
Conditions: Metastatic Pancreatic Carcinoma
Interventions: BIOLOGICAL: CAR2 Anti-CEA CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects on Crying Time in Colicky Infants With the Supplementation of Lactobacillus Reuteri DSM 17938
Status: UNKNOWN
Conditions: Crying Time in Colicky Infants
Interventions: DRUG: L. reuteri DSM 17938|OTHER: The placebo consists of an identical formulation without L. reuteri DSM 17938
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RSV-F Vaccine Dose Ranging Study in Young Women
Status: COMPLETED
Conditions: Respiratory Syncytial Virus (RSV)
Interventions: BIOLOGICAL: Low dose RSV-F Vaccine with Adjuvant|BIOLOGICAL: Low dose RSV-F Vaccine without Adjuvant|BIOLOGICAL: High dose RSV-F Vaccine with Adjuvant|BIOLOGICAL: High dose RSV-F Vaccine without Adjuvant|BIOLOGICAL: Low dose RSV-F Vaccine with Adjuvant [Bedside Mixing]|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Simvastatin as an Add-on Treatment to Interferon-beta-1a for the Treatment of Relapsing-Remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Interferon-beta-1a|DRUG: Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Determine the Fasting Bioequivalence of Reformulated OXY Tablets and Original OxyContin® (OXY) Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Reformulated OXY (oxycodone HCl)|DRUG: Original OxyContin® (OXY) (oxycodone HCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Selinexor, Carfilzomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Refractory Multiple Myeloma
Interventions: DRUG: selinexor|DRUG: carfilzomib|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Carbapenem Antibiotics in Obese Patients.
Status: COMPLETED
Conditions: Obesity
Interventions: PROCEDURE: microdialysis catheter|PROCEDURE: microdialysis catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Liraglutide in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Liraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Are Superficial Parasternal Intercostal Plane (SPIP) Blocks With Bupivacaine and With or Without Adjuvants Helpful for Post-operative Pain After Coronary Artery Bypass Grafting?
Status: UNKNOWN
Conditions: Post-operative Pain Management
Interventions: DRUG: Bupivacaine 0.25% Injectable Solution|DRUG: Bupivacaine 0.25% Injectable Solution, Magnesium Sulfate 200 mg|DRUG: Bupivacaine 0.25% Injectable Solution, Magnesium Sulfate 200 mg, Buprenorphine 300 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Single Ascending Dose (BMS-813160) Study
Status: COMPLETED
Conditions: Accelerated Intimal Hyperplasia
Interventions: DRUG: BMS-813160|DRUG: BMS-813160|DRUG: BMS-813160|DRUG: BMS-813160|DRUG: BMS-813160|DRUG: BMS-813160|DRUG: [14C] BMS-813160|DRUG: Placebo|DRUG: BMS-813160|DRUG: BMS-813160
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury
Status: RECRUITING
Conditions: Traumatic Brain Injury
Interventions: DRUG: Angiotensin (1-7)|DRUG: Sterile saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Compare the Laser Treatment (SLT vs. ALT) in Glaucoma Patients
Status: UNKNOWN
Conditions: Glaucoma
Interventions: PROCEDURE: Argon laser trabeculoplasty|PROCEDURE: Selective laser trabeculoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Efficacy and Safety of Asenapine Using Haloperidol as a Positive Control (41513)(COMPLETED)(P05785)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Haloperidol|DRUG: Asenapine|DRUG: Asenapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GDNF Gene Therapy for Multiple System Atrophy
Status: RECRUITING
Conditions: Multiple System Atrophy
Interventions: BIOLOGICAL: AAV2-GDNF gene therapy|PROCEDURE: Sham (Placebo) Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Depression Screening in Patients With Lung Cancer
Status: COMPLETED
Conditions: Depression|Lung Cancer
Interventions: OTHER: counseling intervention|OTHER: screening questionnaire administration|OTHER: study of socioeconomic and demographic variables|PROCEDURE: psychosocial assessment and care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Increasing Caregiver and Patient Engagement Through PHR Use
Status: TERMINATED
Conditions: Cardiovascular Diseases
Interventions: BEHAVIORAL: Enhanced Pre-Visit Consultation|BEHAVIORAL: Usual Care Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sodium Butyrate For Improving Cognitive Function In Schizophrenia
Status: WITHDRAWN
Conditions: Schizophrenic Disorder|Cognitive Impairment
Interventions: DRUG: Sodium Butyrate|DRUG: Placebo Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Smart Sensor Combined With APP for Individualized Precise Exercise Training in Long Covid-19
Status: RECRUITING
Conditions: Coronavirus Disease|COVID-19|Long Covid-19|Telerehabilitation
Interventions: DEVICE: KNEESUP smart knee assistive device + KNEESUP care APP|DEVICE: KNEESUP care APP|BEHAVIORAL: Healthy consulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hydrocortisone Use During Peri-operation for Pituitary Adenomas
Status: UNKNOWN
Conditions: Pituitary Adenoma|Adrenal Insufficiency|Surgery
Interventions: DRUG: Normal saline|DRUG: Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vessel Injury in Relation With Strut Thickness Assessed by OCT
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Polymer-free stent|DEVICE: Biodegradable-polymer stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TPA in Acute Stroke With COVID Verus Non-COVID-19 Patients
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DRUG: IV tPA (Activase)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability of RO7296682 in Combination With Atezolizumab in Participants With Advanced Solid Tumors.
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: RO7296682|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalency Study of Losartan Potassium/Hydrochlorothiazide 100 mg /25 mg Tablet Under Fed Conditions
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: losartan potassium hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Demonstrate the Effectiveness of Fecal Microbiota Transplantation for Selective Intestinal Decolonization of Patients Colonized by Carbapenemase-producing Klebsiella Pneumoniae
Status: TERMINATED
Conditions: Carbapenemase-producing Enterobacteriaceae Infection
Interventions: BIOLOGICAL: Fecal microbiota transplantation|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Furosemide 40mg + Amiloride Hydrochloride 10mg to Reduct Edema
Status: TERMINATED
Conditions: Congestive Heart Failure
Interventions: DRUG: Diurisa®|DRUG: Lasix ®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intercalating and Maintenance Gefitinib in Combination With Chemotherapy for Advanced EGFR-mutant NSCLC
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer Metastatic|EGFR Activating Mutation
Interventions: DRUG: Gefitinib|DRUG: gemcitabine|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Clinical Effectiveness of L-Oxiracetam Injection
Status: RECRUITING
Conditions: Craniocerebral Injury
Interventions: DRUG: Test group: L-oxiracetam Injection|DRUG: Control group: Oxiracetam Injection|DRUG: Placebo group: Placebo Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin-A for Hidradenitis Suppurativa
Status: NOT_YET_RECRUITING
Conditions: Hidradenitis Suppurativa|Hidradenitis Suppurativa \(HS\)|Hidradenitis Suppurativa, Acne Inversa
Interventions: DRUG: Normal saline|DRUG: Botulinum toxin type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation on Efficacy Between TCM Treatment Using Acupuncture and Tui-na With Physiotherapy on Patellofemoral Pain Syndrome
Status: RECRUITING
Conditions: Patellofemoral Pain Syndrome|Acupuncture|Physiotherapy
Interventions: OTHER: acupuncture and Tui-na manipulations|OTHER: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Neuropathic Pain Associated With Diabetic Peripheral Neuropathy
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathy
Interventions: DRUG: DS-5565 tablet|DRUG: pregabalin capsule|DRUG: Placebo tablet|DRUG: placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASP3700 in Healthy Subjects
Status: WITHDRAWN
Conditions: Healthy Volunteers|Pharmacokinetics of ASP3700
Interventions: DRUG: ASP3700|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Functional Resistance Training to Improve Knee Function After ACL Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injury
Interventions: OTHER: Functional Resistance Training with Brace|OTHER: Control|OTHER: Functional Resistance Training with Elastic Band
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bias Reduction in Academic Recruitment
Status: COMPLETED
Conditions: Internship and Residency|Interview|Education, Medical
Interventions: OTHER: Blinding to academic performance of candidate|OTHER: Usual Interview methodology
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase 3 Clinical Study Investigating the Gingivitis Efficacy of a Test Dentifrice Containing Stannous Fluoride
Status: COMPLETED
Conditions: Gingivitis
Interventions: DRUG: Stannous fluoride|DRUG: Sodium monofluorophosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Sedation Drugs in the Procedure of Administering Surfactant Without Intubation (LISA/MIST)
Status: UNKNOWN
Conditions: Neonatal Respiratory Distress Syndrome|Gestational Age Conditions
Interventions: DRUG: Ketamine|DRUG: Glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: BATS With in Combination With Low Dose IL-1 and GM-CSF for Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Metastatic Pancreatic Adenocarcinoma|Recurrent Pancreatic Carcinoma|Stage III Pancreatic Cancer|Stage IV Pancreatic Cancer
Interventions: BIOLOGICAL: Aldesleukin|BIOLOGICAL: Antibody Therapy|DRUG: Fluorouracil|DRUG: Gemcitabine Hydrochloride|DRUG: Irinotecan Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Leucovorin Calcium|DRUG: Oxaliplatin|DRUG: Paclitaxel Albumin-Stabilized Nanoparticle Formulation|BIOLOGICAL: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography/Computed Tomography (PET/CT) for the Diagnosis of Recurrent Cancer: a Feasibility Study
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer|Breast Cancer|Head and Neck Cancer|Ovarian Cancer|Esophageal Cancer|Lymphoma
Interventions: OTHER: PET/CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Duration of Antibiotic Therapy in the Treatment of Severe Postoperative Peritonitis Admitted in ICU
Status: COMPLETED
Conditions: Postoperative Peritonitis
Interventions: OTHER: Duration of antibiotic therapy limited to 8 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Proof of Concept Clinical Study to Investigate the Effects of an Experimental Cosmetic Moisturiser on the Barrier Function of Human Skin on the Face and Forearm
Status: COMPLETED
Conditions: Skin Care
Interventions: OTHER: Test product (Moisturising cream)|OTHER: Positive control (Commercial market place moisturising cream)|OTHER: No treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Recombinant Human Erythropoietin Beta (NeoRecormon) in Anemic Cancer Participants Treated With Chemotherapy
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: r-HuEPO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Uncovering Neural and Immune Mechanisms of Chronic Pain in Post Treatment Lyme Syndrome
Status: TERMINATED
Conditions: Post Treatment Lyme Syndrome (PTLS)|Chronic Pain
Interventions: DRUG: Milnacipran and D-cycloserine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemo-endocrine Therapy Versus Chemotherapy Alone in ER-positive, HER2-negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer Female
Interventions: DRUG: letrozole, leuprorelin, fluorouracil, epirubicin, cyclophosphamide, docetaxel|DRUG: fluorouracil, epirubicin, cyclophosphamide, docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction Study of Mitiglinide and Gemfibrozil
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: placebo for gemfibrozil|DRUG: gemfibrozil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed Disodium With or Without Erlotinib Hydrochloride in Treating Patients With Stage IIIB-IV or Recurrent Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Bronchioloalveolar Carcinoma|Large Cell Lung Carcinoma|Lung Adenocarcinoma|Recurrent Non-Small Cell Lung Carcinoma|Stage IIIB Non-Small Cell Lung Cancer|Stage IV Non-Small Cell Lung Cancer
Interventions: DRUG: Erlotinib Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Pemetrexed Disodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Study of Intramuscular Olanzapine Depot in Patients With Schizophrenia or Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenic Disorders|Schizoaffective Disorder
Interventions: DRUG: Intramuscular olanzapine depot
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Combination With Epacadostat or Placebo in Cisplatin-ineligible Urothelial Carcinoma (KEYNOTE-672/ECHO-307)
Status: COMPLETED
Conditions: UC (Urothelial Cancer)
Interventions: DRUG: Pembrolizumab|DRUG: Epacadostat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study Evaluating the Fixed-Dose Combination of Candesartan Plus Amlodipine in Participants With Mild/Moderate Essential Hypertension
Status: WITHDRAWN
Conditions: Hypertension
Interventions: DRUG: Amlodipine|DRUG: TCV-116CCB|DRUG: Amlodipine Placebo|DRUG: TCV-116CCB Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of LX4211 in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: LX4211 Low Dose|DRUG: LX4211 High Dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Core Strengthening Versus Lower Limb Proprioceptive Neuromuscular Facilitation Techniques in Chronic Stroke Patients
Status: RECRUITING
Conditions: Stroke
Interventions: OTHER: core strengthening exercises|OTHER: Proprioceptive Neuromuscular Facilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Remimazolam on the Recovery Quality After Day Surgery
Status: COMPLETED
Conditions: Elderly Patients|Ambulatory Surgery
Interventions: DRUG: Remimazolam besylate|DRUG: etomidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Tacrolimus and Mycophenolate Mofetil in Kidney Transplant Recipients With Hyperkalemia Receiving Patiromer
Status: COMPLETED
Conditions: Hyperkalemia|Kidney Transplant
Interventions: DRUG: Patiromer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Vagus Nerve Stimulation for the Treatment of Lupus
Status: TERMINATED
Conditions: Systemic Lupus Erythematosus
Interventions: DEVICE: TENS for vagus stimulation|DEVICE: TENS for sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ultrasound-guided Axillary Nerve Block Versus Ultrasound-guided Peripheral Forearm Block in Patients Undergoing Hand Surgery
Status: COMPLETED
Conditions: Surgery|Anesthesia, Local
Interventions: PROCEDURE: Ultrasound-guided distal peripheral nerve block|PROCEDURE: Ultrasound-guided quadruple-injection axillary nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Mobile-based Education and Exercise Program Given to Patients With Total Knee Replacement Surgery
Status: COMPLETED
Conditions: Replacement, Knee
Interventions: OTHER: The mobile-based education and exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Proprioceptive Neuromuscular Facilitation, Myofascial Releasing Maneuvers and Home Exercises on Pain and Jaw Function in Patients With Bruxism
Status: COMPLETED
Conditions: Exercise|Bruxism|Myofascial
Interventions: BEHAVIORAL: PNF, Myofascial Releasing Maneuvers, Home Exercise Group|BEHAVIORAL: Myofascial Releasing Maneuvers and Home Exercises Group|BEHAVIORAL: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Syndromes|Keratoconjunctivitis Sicca
Interventions: DRUG: KPI-121 0.25% Ophthalmic Suspension|DRUG: Vehicle of KPI-121 0.25% Ophthalmic Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of the Efficacy and Safety of Raphamin in Prevention of Recurrences of Chronic Bacterial Cystitis
Status: RECRUITING
Conditions: Cystitis Chronic|Cystitis Bacterial|Recurrence of Chronic Bacterial Cystitis
Interventions: DRUG: Raphamin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hemodynamic, Vascular and Muscular Parameters of Exercise Capacity in Single-Ventricle Patients With Fontan Procedure
Status: COMPLETED
Conditions: Single-ventricle|Fontan Procedure|Hemodynamic Instability|Arterial Stiffness|Muscle Oxygenation|Exercise Capacity
Interventions: OTHER: Demographic and Clinical Characteristics, Maximal Exercise Capacity, Submaximal Exercise Capacity, Hemodynamic Parameters, Muscle Strength, Muscle Oxygenation, Vascular Function
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Davunetide (AL-108) in Predicted Tauopathies - Pilot Study
Status: COMPLETED
Conditions: Predicted Tauopathies, Including|Progressive Supranuclear Palsy|Frontotemporal Dementia With Parkinsonism Linked to Chromosome 17|Corticobasal Degeneration Syndrome|Progressive Nonfluent Aphasia
Interventions: DRUG: davunetide (AL-108, NAP)|DRUG: Placebo nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Mental Health Status of the General Population During the COVID-19 Pandemic and Its Association With Adherence to Government-initiated Non-pharmacological Epidemiological Interventions (NPI's)
Status: COMPLETED
Conditions: Depression|Generalized Anxiety|Adherence to Non-pharmacological Epidemiological Interventions (NPIs)
Interventions: OTHER: Cross-sectional study investigating the association of NPIs with mental health
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Shock Index, Modified Shock Index and Age-related Shock Index for Predicting Post-spinal Hypotension in Elderly Patients
Status: UNKNOWN
Conditions: Anesthesia Morbidity|Procedural Hypotension|Intraoperative Hypotension|Geriatrics
Interventions: PROCEDURE: spinal anesthesia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fortified Skimmed Mother's Milk in the Management of Chylothorax
Status: COMPLETED
Conditions: Chylous Pleural Effusion Following Cardiothoracic Surgery
Interventions: OTHER: Skimmed mother's milk|OTHER: Specialized Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Trastuzumab Emtansine, Paclitaxel, and Pertuzumab in Patients With HER2-Positive, Locally Advanced or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: paclitaxel|DRUG: pertuzumab [Perjeta]|DRUG: trastuzumab emtansine [Kadcyla]|DRUG: paclitaxel|DRUG: trastuzumab emtansine [Kadcyla]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Black Garlic Extract on Cholesterol LDL Levels
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DIETARY_SUPPLEMENT: Aged black garlic extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Etanercept for the Treatment of Lupus Nephritis
Status: TERMINATED
Conditions: Lupus Nephritis
Interventions: DRUG: Etanercept|DRUG: Lupus Treatment- Standard of Care|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT