pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Assessment of Safety and Efficacy of IM19 for Recurrent or Refractory (R/R) Non-Hodgkin's Lymphoma(NHL) Patients
Status: RECRUITING
Conditions: NHL
Interventions: DRUG: IM19 CAR-T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Auriculotherapy in the Treatment of Pre-Operative Anxiety
Status: RECRUITING
Conditions: Anxiety Preoperative
Interventions: DEVICE: Auriculotherapy cryopuncture device without nitrogen gas|DEVICE: Auriculotherapy cryopuncture device with nitrogen gas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dacomitinib Plus PD-0325901 in Advanced KRAS Mutant NSCLC
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: Dacomitinib|DRUG: PD-0325901|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Metastatic Castration Resistant Prostate Cancer|Renal Cell Carcinoma|Non-small Cell Lung Cancer|Colorectal Cancer|Squamous Cell Carcinoma of Head and Neck|Triple-Negative Breast Cancer|Urothelial Carcinoma|Cholangiocarcinoma|GastroEsophageal Cancer|Pancreatic Cancer|Sarcoma
Interventions: DRUG: Part 1 TPST-1120|DRUG: Part 2 TPST-1120 + nivolumab|DRUG: Part 3 TPST-1120|DRUG: Part 4 TPST-1120 + nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics
Status: UNKNOWN
Conditions: Drug Induced Weight Gain
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ALK21-006EXT: Long-term Safety of Medisorb® Naltrexone (VIVITROL®) in Alcohol- or Opioid-dependent Adults (Extension of Study ALK21-006 [NCT01218997])
Status: TERMINATED
Conditions: Alcoholism|Opiate Dependence
Interventions: DRUG: Medisorb naltrexone 380 mg|DRUG: Oral naltrexone to Medisorb naltrexone 380 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lapatinib Ditosylate in Treating Patients With Unresectable Liver or Biliary Tract Cancer
Status: COMPLETED
Conditions: Adult Primary Hepatocellular Carcinoma|Advanced Adult Primary Liver Cancer|Localized Unresectable Adult Primary Liver Cancer|Recurrent Adult Primary Liver Cancer|Recurrent Extrahepatic Bile Duct Cancer|Recurrent Gallbladder Cancer|Unresectable Extrahepatic Bile Duct Cancer|Unresectable Gallbladder Cancer
Interventions: DRUG: lapatinib ditosylate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Episiotomy Wound Care, Episiotomy Wound Healing and Pain Perception
Status: COMPLETED
Conditions: Episiotomy Wound|Wound Healing|Pain|Training, Toilet
Interventions: OTHER: Episiotomy Wound Care and Genital Hygiene Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial)
Status: COMPLETED
Conditions: Spinal Stenosis|Low Back Pain
Interventions: PROCEDURE: Epidural steroid with local anesthetic injection|PROCEDURE: Epidural local anesthetic injection|DRUG: Epidural steroid injection|DRUG: Epidural local anesthetic injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Two-Stage Phase 1 Dose Escalation Pharmacokinetic Study of Tarceva in Patients With Stage IIIB/IV Non-small Cell Lung Cancer Who Continue to Smoke After Failure of One or Two Prior Chemotherapy Regimens
Status: COMPLETED
Conditions: NSCLC
Interventions: DRUG: Tarceva
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexketoprofen and Ibuprofen in Long Bone Fractures
Status: RECRUITING
Conditions: Pain|Bone Fracture
Interventions: DRUG: Ibuprofen 800 mg|DRUG: Dexketoprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between Febuxostat Versus Vitamin E in Non-alcoholic Steatohepatitis Patients With Hyperuricemia
Status: RECRUITING
Conditions: Non Alcoholic Steatohepatitis|Hyperuricemia
Interventions: DRUG: Febuxostat 80 MG Oral Tablet|DRUG: vit E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine for Prevention of Recurrent Miscarriage.
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Miscarriage|First Trimester Abortion
Interventions: DRUG: Hydroxychloroquine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Initial Severity and Antidepressant Efficacy for Anxiety Disorders: an Individual Patient Data Meta-analysis
Status: UNKNOWN
Conditions: Anxiety Disorders|Panic Disorder|Obsessive-compulsive Disorder|Post-traumatic Stress Disorder|Generalized Anxiety Disorder|Social Anxiety Disorder
Interventions: DRUG: paroxetine, duloxetine, fluoxetine or venlafaxine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility of Using the Livongo-Insulia Study App for Patients With Type 2 Diabetes [Pilot Study]
Status: TERMINATED
Conditions: Type 2 Diabetes Treated With Insulin
Interventions: DEVICE: Livongo-Insulia Study App
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Different Timings of Protein Supplementation in Hemodialysis Patients
Status: COMPLETED
Conditions: Protein Supplementation
Interventions: DIETARY_SUPPLEMENT: oral protein nutritional supplement (ONS) (Fresubin protein powder 25mg/5scoops per hemodialysis session)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Scalp Cooling for Chemotherapy-Induced Alopecia in Patients of Color
Status: RECRUITING
Conditions: Alopecia
Interventions: DEVICE: Scalp cooling with hairstyle|DEVICE: Scalp cooling with conditioner and water emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Working Memory Training and Neurofeedback for Children With ADHD, a Pilot Study
Status: COMPLETED
Conditions: ADHD
Interventions: BEHAVIORAL: Cogmed Robomemo, working memory training|BEHAVIORAL: Othmer, neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Nutrition for Prevention of Hypertension in Pregnancy
Status: UNKNOWN
Conditions: Blood Pressure|Pregnancy
Interventions: DIETARY_SUPPLEMENT: Riboflavin (5mg)|DIETARY_SUPPLEMENT: 5-methyltetrahydrofolate (400µg)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neuro-modulation of the Depressed Brain Using Working Memory Training and Transcranial Direct Current Stimulation (tDCS)
Status: COMPLETED
Conditions: Depression
Interventions: OTHER: active tDCS and working memory training|OTHER: sham tDCS and working memory training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of a Single Suspension Injection of Investigational Capsid Inhibitors Compared to Placebo in Healthy Adults
Status: RECRUITING
Conditions: HIV Infections
Interventions: DRUG: VH4004280|DRUG: Placebo|DRUG: VH4011499
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fed Study of Oxycodone Hydrochloride 30 mg Tablets and Roxicodone™ 30 mg Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Roxicodone™ tablet 30 mg|DRUG: Oxycodone hydrochloride tablet 30 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Study to Determine the Safety of Epoetin Alfa and Whether Epoetin Alfa Can Reduce the Need for Blood Transfusions in Patients After Major Orthopedic Surgery.
Status: COMPLETED
Conditions: Blood Transfusion|Orthopedic Procedures|Anemia
Interventions: DRUG: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Long Covid Syndrome
Status: COMPLETED
Conditions: Post-Acute COVID-19 Syndrome|Biofeedback, Psychology|Quality of Life|Depressive Symptoms|Fatigue|Anxiety|Pain|Cognitive Symptom
Interventions: DEVICE: Biofeedback training|DRUG: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Value of Robotic Rectopexy for the Treatment of Complex Pelvic Floor Dysfunction
Status: UNKNOWN
Conditions: Rectal Prolapse|Pelvic Organ Prolapse
Interventions: PROCEDURE: Minimally invasive rectopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing The Outcome Of High Flow Oxygen Versus Conventional Oxygen In Extubated Patients After Lung Resection.
Status: UNKNOWN
Conditions: Pulmonary Resection|Oxygen Therapy
Interventions: OTHER: Oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 12-week, Multicentric Study to Evaluate the Safety and Efficacy of Bisoprolol in Filipino Hypertensive Subjects With Diabetes
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Bisoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Tricuspid Valve Annuloplasty in Patients Undergoing Mitral Valve Surgery
Status: UNKNOWN
Conditions: Tricuspid Valve Insufficiency
Interventions: PROCEDURE: Tricuspid Valve Annuloplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Lactate Dehydrogenase as Decision Support for Admissions to Neonatal Ward
Status: COMPLETED
Conditions: Neonatal|Asphyxia
Interventions: DEVICE: The Neo Hilda|PROCEDURE: Traditional evaluation|DEVICE: iPhone 4S
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Physiological Control for Mechanical Circulatory Devices
Status: TERMINATED
Conditions: Heart Failure
Interventions: DEVICE: Physiological Control Module for the Medtronic -"HVAD" Left Ventricular Assist Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Cilostazol for HFpEF
Status: COMPLETED
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: Cilostazol 100Mg Tab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Longan Syrup in Healthy Volunteers With Insomnia
Status: UNKNOWN
Conditions: Insomnia
Interventions: DIETARY_SUPPLEMENT: longan syrup|DIETARY_SUPPLEMENT: Placebo syrup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Total IgE (Immunoglobulin E) and Der p 1 (d1) Specific IgE in Induced Sputum in Patients With Allergic and Non-allergic Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Induced Sputum
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Cyanocobalamin in Avocado Oil Cream With Steroid Combination Ointment
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: COMBINATION_PRODUCT: Potent topical steroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Assess Safety and Efficacy of Vilaprisan in Subjects With Endometriosis
Status: TERMINATED
Conditions: Endometriosis
Interventions: DRUG: Vilaprisan (BAY1002670)|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Transcutaneous Spinal Direct Current Stimulation on Mobility in Cases With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Transcranial Direct Current Stimulation
Interventions: DEVICE: Transcutaneous Spinal Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Abemaciclib + Pembrolizumab In Glioblastoma
Status: WITHDRAWN
Conditions: Glioblastoma
Interventions: DRUG: Pembrolizumab|DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Artesunate + Amodiaquine With SLD of Primaquine for Treatment of Falciparum Malaria in Zanzibar
Status: COMPLETED
Conditions: Plasmodium Falciparum Malaria
Interventions: DRUG: Artesunate-amodiaquine given with single low dose primaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of the Effect of CVL-865 on Panic Symptoms Induced by Carbon Dioxide Inhalation in Healthy Subjects
Status: COMPLETED
Conditions: Panic Disorder
Interventions: DRUG: CVL-865 High dose|DRUG: Alprazolam 1mg XR|DRUG: Placebo|DRUG: CVL-865 low dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Abdominal Abscesses With or Without Fibrinolysis
Status: COMPLETED
Conditions: Abdominal Abscess|Tissue Plasminogen Activator
Interventions: PROCEDURE: Tissue plasminogen activator abscess flush|PROCEDURE: Saline flush of abscess
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Effect of Food on the Pharmacokinetics of PCI-32765
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Sequence 1: PCI-32765|DRUG: Sequence 2: PCI-32765|DRUG: Sequence 3: PCI-32765|DRUG: Sequence 4: PCI-32765|DRUG: Sequence 5: PCI-32765
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Biologic Therapy
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: Matching Placebo for Upadacitinib|DRUG: Upadacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Transition of the Foot Strike Pattern on Pain and Disability in Cadets With Musculoskeletal Pain
Status: TERMINATED
Conditions: Chronic Musculoskeletal Pain
Interventions: OTHER: Transition from the Rearfoot to the Forefoot and Midfoot|OTHER: Usual Treatment Group|OTHER: Muscle Strengthening Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Diuretic Therapy for Acute Decompensated Heart Failure
Status: WITHDRAWN
Conditions: Acute Decompensated Heart Failure
Interventions: DRUG: Furosemide plus Chlorothiazide|DRUG: Furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Simvastatin and Its Metabolite Simvastatin Acid With and Without Concomitant Administration of Telmisartan in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Telmisartan|DRUG: Simvastatin|DRUG: Telmisartan placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Marrow Infiltrating Lymphocytes - Non-Small Cell Lung Cancer (MILs™ - NSCLC) Alone or in Combination With Nivolumab With or Without Tadalafil in Locally Advanced and Unresectable or Metastatic NSCLC
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer|Lung Cancer|Lung Cancer Metastatic|Lung Cancer, Non-small Cell|Non Small Cell Lung Cancer Metastatic|NSCLC|Non-small Cell Lung Cancer|Non-small Cell Lung Cancer Metastatic
Interventions: BIOLOGICAL: MILs™ - NSCLC|BIOLOGICAL: nivolumab|DRUG: tadalafil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-Centre Study in Patients Undergoing Total Hip Arthroplasty With the Smith+Nephew CATALYSTEM™ Primary Hip System
Status: NOT_YET_RECRUITING
Conditions: Total Hip Arthroplasty (THA)|Osteoarthritis|Degenerative Joint Disease|Inflammatory Arthritis|Avascular Necrosis|Post-traumatic Arthritis|Congenital Hip Dysplasia
Interventions: DEVICE: CATALYSTEM
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metabolic Availability of Methionine and Lysine From Rice, Wheat, Chickpea and Lentil in Adult Men
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Dietary Intakes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Postoperative Electrical Muscle Stimulation (POEMS)
Status: UNKNOWN
Conditions: Muscle Atrophy|Postoperative Complications
Interventions: DEVICE: Electrical Muscle stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study on the Efficacy of Vetiver Essential Oil Aroma on Depression/Anxiety People
Status: UNKNOWN
Conditions: Anxiety Depression Disorder
Interventions: DEVICE: Limon essential oil aromatherapy|DEVICE: Vetiver essential oil aromatherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy Study of Human ESC-derived Neural Precursor Cells in the Treatment of Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: BIOLOGICAL: NPC transplantation|DRUG: Levodopa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study of Risperidone and Topiramate Administered Alone and in Combination in Patients With Bipolar Disorder or Schizoaffective Disorders
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: topiramate|DRUG: topiramate|DRUG: risperidone|DRUG: topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Vibrational Force During Orthodontic Treatment With Aligners
Status: COMPLETED
Conditions: Orthodontic Tooth Movement|Gingival Crevicular Fluid|Biomarkers
Interventions: DEVICE: Vibrational forces|PROCEDURE: Orthodontic treatment with clear aligners
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fixed-dose Activated Versus Variable-dose Inactivated Prothrombin Complex Concentrate for Warfarin-associated Major Bleed
Status: COMPLETED
Conditions: Hemorrhage
Interventions: DRUG: fixed-dose activated prothrombin complex concentrate|DRUG: variable-dose inactivated prothrombin complex concentrate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Recurrence Rate of 2 Herniotomy Techniques in Children Older Than 2 Years
Status: COMPLETED
Conditions: Hernia, Inguinal
Interventions: PROCEDURE: Herniotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Effects of Progressive Relaxation Exercises and Aquatic Therapy in Fibromyalgia.
Status: RECRUITING
Conditions: Fibromyalgia
Interventions: OTHER: progressive muscle relaxation therapy|OTHER: aquatic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Administration of Tramadol and Ketorolac Separately and Simultaneously to Assess a Potential Pharmacokinetic Interaction
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Tramadol hydrochloride 25 mg capsule|DRUG: Ketorolac Tromethamine 10 mg tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic (PK), Pharmacodynamic (PD), and Safety Study of Subcutaneously Administered Humalog® With and Without Recombinant Human Hyaluronidase (rHuPH20)and Humulin-R® With and Without rHuPH20
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Humalog|DRUG: Humulin-R|DRUG: Recombinant human hyaluronidase PH20 (rHuPH20)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Tolerability of I.V. Infusion of MB07133 in Patients With Unresectable Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: MB07133 300mg/m2/day|DRUG: MB07133 600 mg/m2/day|DRUG: MB07133 1200 mg/m2/day|DRUG: MB07133 1800 mg/m2/day|DRUG: MB07133 2400 mg/m2/day
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy and the Tolerance of Pelvic-prostatic Hypo-fractionated Radiotherapy Followed by Boost in Patients With Prostate Adenocarcinoma Adverse Intermediate Risk or High Localized Risk
Status: RECRUITING
Conditions: To Evaluate the Rate of Digestive and Urinary Toxicity
Interventions: RADIATION: prostatic boost in brachytherapy with high dose rate (HDR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy Effect of Laser on Wound Healing and Bone Regeneration of Dental Sockets
Status: NOT_YET_RECRUITING
Conditions: Tooth Extraction
Interventions: OTHER: Diode Laser 980 nm.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultrasound Guidance for Embryo Transfer
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: Transvaginal Ultrasound Guided ET|PROCEDURE: Transabdominal Ultrasound Guided ET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Variation of Spatiotemporal Parameters in School Children Carrying Different Backpack Loads
Status: COMPLETED
Conditions: Child, Only|Gait, Unsteady
Interventions: OTHER: Backpack child's body weight
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Concurrent Low Intensity Shockwave Therapy on Collagenase Clostridium Histolyticum for Peyronie's Disease
Status: RECRUITING
Conditions: Peyronie Disease|Erectile Dysfunction
Interventions: DRUG: Collagenase Clostridium Histolyticum|DEVICE: Storz Duolith LiSWT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paracervical Block Versus Transcervical Block in Outpatient Procedural Hysteroscopy
Status: NOT_YET_RECRUITING
Conditions: Myoma;Uterus|Polyp Uterus
Interventions: DRUG: Bupivacaine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of NMES on Energy Expenditure, Glycaemia and Hormonal Responses to Glucose Ingestion
Status: COMPLETED
Conditions: Energy Expenditure|Metabolic Health
Interventions: BEHAVIORAL: Sitting|BEHAVIORAL: Standing|BEHAVIORAL: Self-selected maximal intensity of neuromuscular electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Closed Vitrification of Oocytes
Status: WITHDRAWN
Conditions: Infertility
Interventions: PROCEDURE: Oocytes are vitrified/stored using a closed device|PROCEDURE: Oocytes are vitrified/stored using an open device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Rectus Femoris Tenotomy Versus Botulinum Toxin A for Stiff Knee Gait After Stroke
Status: UNKNOWN
Conditions: Stroke|Spasticity
Interventions: PROCEDURE: Tenotomy of the proximal rectus femoris tendon|DRUG: Botulinum Toxin injection in the rectus femoris muscle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Influence of the Strategy Intraoperative Anesthetic (Desflurane Versus Propofol) on Cognitive and Psychomotor Functions in Output Post Interventional Room Monitoring - COGNIDES
Status: COMPLETED
Conditions: Orthopedic Surgery|Total Hip Prosthesis|Total Knee Replacement
Interventions: DRUG: Intraoperative anesthetic strategy by Propofol|DRUG: Intraoperative anesthetic strategy by Desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation in Estonian Conscripts
Status: COMPLETED
Conditions: Vitamin D Deficiency|Military Activity|Physical Stress
Interventions: DIETARY_SUPPLEMENT: Vitamin D3 capsules 4000IU/100µg.|DIETARY_SUPPLEMENT: Vitamin D3 capsules 600IU/15µg.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Neurostimulation of Spinal Nerves That Affect the Heart
Status: UNKNOWN
Conditions: Chronic Heart Failure
Interventions: DEVICE: Neurostimulation + Medication Management (Standard of Care)|DRUG: Standard of Care (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Comparison of the Open and Endovascular Surgical Methods for the Treatment of Long Atherosclerotic Lesions of the Femoral-popliteal Segment Below the Knee, TASC D in Patients With Critical Limb Ischemia
Status: RECRUITING
Conditions: Atherosclerotic Ischemic Disease|Critical Limb Ischemia|Superficial Femoral Artery Occlusion|Popliteal Artery Occlusion
Interventions: DEVICE: Endovascular recanalization|OTHER: Open surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Corticosteroids for Cancer Pain
Status: COMPLETED
Conditions: Cancer|Pain
Interventions: DRUG: Methylprednisolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Nutritional Supplementation in Preventing Malnutrition in Children With Infection in Karamoja, Uganda
Status: COMPLETED
Conditions: Child Malnutrition|Infant Morbidity
Interventions: DIETARY_SUPPLEMENT: Dietary Supplement: Nutrition supplement with RUTF or MNP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vitality Acupunch Exercise Program for Older Adults With Sarcopenia
Status: COMPLETED
Conditions: Muscle Mass|Muscle Strength|Sleep Quality
Interventions: OTHER: Vitality acupunch (VA) exercise program|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of Pemigatinib Versus Chemotherapy in Unresectable or Metastatic Cholangiocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Unresectable Cholangiocarcinoma|Metastatic Cholangiocarcinoma
Interventions: DRUG: Pemigatinib|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MK0653C in High Cardiovascular Risk Patients With High Cholesterol (Switch Study)(MK-0653C-162)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: ezetimibe 10 mg|DRUG: atorvastatin|DRUG: Comparator: rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Health Information Technology to Support Clinical Decision Making in Obesity Care
Status: UNKNOWN
Conditions: Childhood Overweight|Childhood Obesity
Interventions: OTHER: HeartSmartKids & Web-based Provider Training|OTHER: Web-based Provider Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: MYFEMBREE®: A Retrospective Cohort Study Using an Administrative Healthcare Database to Assess Pregnancy Outcomes in Women Treated With Relugolix Combination Therapy
Status: NOT_YET_RECRUITING
Conditions: Pregnancy Related|Pregnancy Complications|Pregnancy, High Risk
Interventions: DRUG: Relugolix + Estradiol + Norethindrone Acetate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vending Machine Naloxone Distribution for Your Community (VENDY)
Status: NOT_YET_RECRUITING
Conditions: Harm Reduction|Naloxone|Opioid Overdose
Interventions: BEHAVIORAL: VENDY
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Role of Supplementary Material in Journal Articles QT
Status: COMPLETED
Conditions: Incentive
Interventions: OTHER: Group 1 information|OTHER: Group 2 information|OTHER: Group 3 information|OTHER: Group 4 information|OTHER: Group 5 no information|OTHER: Group A Reminder|OTHER: Group B Reminders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Mucinex Exploratory Cold Study
Status: COMPLETED
Conditions: Common Cold
Interventions: DRUG: guaifenesin (Mucinex)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Acid Reflux on Respiratory Physiology During Exercise in Athletes With GER-Response to Acid Suppression
Status: TERMINATED
Conditions: Exercise Triggered Asthma|Gastroesophageal Reflux
Interventions: DRUG: Nexium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Placebo-Controlled Evaluation of Intranasal Dexmedetomidine for Postoperative Analgesia Following Bunionectomy
Status: TERMINATED
Conditions: Pain, Post-operative
Interventions: DRUG: Intranasal Dexmedetomidine|OTHER: Intranasal Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Solriamfetol in Binge Eating Disorder
Status: RECRUITING
Conditions: Binge Eating Disorder
Interventions: DRUG: Solriamfetol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chronic Hepatitis C Non-Responder Study With AdoMet and Betaine
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: S-adenosyl-L-methionine|DRUG: betaine|DRUG: pegylated interferon alpha2b|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Placebo Versus Chlorpheniramine for the Prevention of Allergic Transfusion Reactions.
Status: RECRUITING
Conditions: Allergic Transfusion Reaction
Interventions: DRUG: Placebo|DRUG: Chlorpheniramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Preoperative Nutrition for Crohn's Disease Patients
Status: NOT_YET_RECRUITING
Conditions: Malnutrition|Crohn Disease
Interventions: DIETARY_SUPPLEMENT: Exclusive Enteral Nutrition|OTHER: High energy / protein diet.|OTHER: Standard nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Pharmacokinetics, Pharmacodynamics, and Tolerabiltiy of Betrixaban in Patients With Mild, Moderate, and Severe Renal Impairment
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Betrixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Artery Catheterization and Carvedilol Early Initiation in Cardiogenic SHOCK Due to HFrEF
Status: RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction|Cardiogenic Shock
Interventions: DEVICE: Pulmonary artery catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Registry Study to Evaluate the Performance and Safety of Roxwood Medical Catheters in Arteries of Participants With a Stenotic Lesion or Chronic Total Occlusion (CTO)
Status: WITHDRAWN
Conditions: Chronic Total Occlusion|Atherosclerosis|Coronary Artery Disease|Peripheral Artery Disease
Interventions: DEVICE: Roxwood Anchoring Catheters|DRUG: Acetylsalicylic Acid|DRUG: Heparin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PR-104 and Docetaxel or Gemcitabine in Treating Patients With Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: PR-104|DRUG: docetaxel|DRUG: gemcitabine hydrochloride|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sarpogrelate, a Serotonin Receptor Antagonist, on Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Sarpogrelate|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Two Daily Disposable Toric Soft Contact Lenses Over One Week of Wear
Status: COMPLETED
Conditions: Ocular Physiology
Interventions: DEVICE: PRECISION1® for Astigmatism Contact Lenses|DEVICE: MyDay® Toric Soft Contact Lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II, FIH, Dose Escalation Trial of TL-895 and Expansion of TL-895 Monotherapy and Combination Therapy With Navtemadlin in Tx-Naïve and R/R CLL/SLL Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed/Refractory B Cell Malignancies|Mantle Cell Lymphoma and Diffuse Large B Cell Lymphoma|Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|Treatment-Naive B Cell Malignancies
Interventions: DRUG: TL-895|DRUG: Navtemadlin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRevention Of BLeeding in hEmatological Malignancies With Antifibrinolytic (Epsilon Aminocaproic Acid)
Status: TERMINATED
Conditions: Hematological Malignancies|Thrombocytopenia
Interventions: DRUG: EACA|OTHER: Platelet transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of the Live Attenuated Tetravalent Dengue Vaccine Against DENV-2 and DENV-3 Challenge
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: TetraVax-DV-TV003 (TV003)|BIOLOGICAL: rDEN2Δ30-7169 (DENV-2)|BIOLOGICAL: rDEN3Δ30 (DENV-3)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study for Ecabet Ophthalmic Solution for Treating Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: Ecabet 2.83%|DRUG: Ecabet 3.70%|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Different ''Exercise Snacking'' Modalities on Glycemic Control in Patients With Type 2 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2|Overweight or Obesity
Interventions: BEHAVIORAL: HIIT snacks|BEHAVIORAL: Sprint snacks|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Reslizumab Treatment in Patients With Moderate to Severe Asthma
Status: COMPLETED
Conditions: Eosinophilic Asthma
Interventions: DRUG: Reslizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-Intensity Extracorporeal Shock Wave Treatment for Erectile Dysfunction: A Randomized, Controlled, Double Blind Trial
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DEVICE: Li-ESWT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interventions to Improve Hypertension Control and Reduce Cardiovascular Disease Risk
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: Lifestyle interventions to lower blood pressure for patients|BEHAVIORAL: MD CQI-type intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of JDB0131 Benzenesulfonate Tablets in Patients With Drug-sensitive Pulmonary Tuberculosis
Status: RECRUITING
Conditions: Drug-resistant Tuberculosis
Interventions: DRUG: JDB0131|DRUG: Delamanid|DRUG: Ethylpyrazine rifampicide (II)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Random Noise Stimulation (tRNS) Over Fronto-temporal Cortex Improves Verbal Fluency and Empathy in Autism Children
Status: COMPLETED
Conditions: Autism|ASD
Interventions: DEVICE: tRNS Fronto-temporal cortex|DEVICE: tRNS over fusiform temporal cortex|DEVICE: tRNS with sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Observational Study to Evaluate Pediatric Multiple Sclerosis in Brazil
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis
Interventions: DIAGNOSTIC_TEST: anti-aquaporin-4 antibody|DIAGNOSTIC_TEST: anti-myelin oligodendrocyte glycoprotein
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Aprepitant, Ramosetron, and Dexamethasone for Chemotherapy-Induced Nausea and Vomiting in Patients With Ovarian Cancer Treated With Taxane/Carboplatin
Status: COMPLETED
Conditions: Chemotherapy-Induced Nausea and Vomiting|Ovarian Cancer
Interventions: DRUG: Aprepitant/Ramosetron/Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vasopressin Injection Technique to Preserve Ovarian Reserve in Surgery for Unilateral Ovarian Endometriomas
Status: UNKNOWN
Conditions: Unilateral Ovarian Endometrioma
Interventions: PROCEDURE: Vasopressin injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety of Overestimation of a Meal Insulin Bolus in the Context of Dual-hormone Closed-loop Operation
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: OTHER: Dual-hormone closed-loop|DRUG: Insulin|DRUG: Glucagon|DEVICE: Dexcom G4 Platinum glucose sensor|DEVICE: Accu Chek Combo insulin pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Activation of Autophagy and Suppression of Apoptosis by Dapagliflozin Attenuates Inflammatory Bowel Disease
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases
Interventions: DRUG: Mesalamine|DRUG: Dapagliflozin 10mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety of Adipose Derived Mesenchymal Stem Cell Transplantation for Type 1 Diabetes Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 1 Diabetes
Interventions: COMBINATION_PRODUCT: adipose-derived messenchymal stem cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of AEGR-733 to Treat Homozygous Familial Hypercholesterolemia (FH)
Status: COMPLETED
Conditions: Homozygous Familial Hypercholesterolemia
Interventions: DRUG: AEGR-733
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Relative Bioavailability of Two New Relacorilant Capsule Variants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Relacorilant (3x100 mg softgel capsules)|DRUG: Relacorilant (3x100 mg hard-shell capsules)|DRUG: Relacorilant (6x50mg hard-shell capsules)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Randomized, Double-Blinded, Placebo-Controlled, Two-Way Crossover Study to Investigate the Safety and Toleration of Single Dose Sildenafil in Subjects Receiving Chronic UK-369,0031
Status: COMPLETED
Conditions: Prostatic Hyperplasia|Urinary Bladder, Overactive|Erectile Dysfunction
Interventions: DRUG: UK369,003|DRUG: sildenafil|DRUG: sildenafil matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Biomarkers in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: D Serine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Infusion of Fentanyl in Preterm on MV
Status: COMPLETED
Conditions: Pain|Infant, Premature, Diseases|Respiration; Insufficient or Poor, Newborn
Interventions: DRUG: Fentanyl|DRUG: 5% glucose solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: GS-6615 in Adults With Chronic Stable Angina and Coronary Artery Disease
Status: WITHDRAWN
Conditions: Ischemic Heart Disease
Interventions: DRUG: GS-6615|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT