pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety, Tolerability and Activity Study of Ibudilast in Subjects With Progressive Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis, Primary Progressive|Multiple Sclerosis, Secondary Progressive
Interventions: DRUG: ibudilast|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Evaluate if Contrast Enhanced Ultrasound (CEUS) Can Predict Treatment Response in Triple Negative Breast Cancer (TNBC) Patients Receiving Combined Chemotherapy and Immune Checkpoint Inhibitors (ICI).
Status: RECRUITING
Conditions: Breast Cancer|Contrast Enhanced Ultrasound
Interventions: DRUG: Lumason
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A RCT to Compare the Effectiveness of Nebulized Anticholinergics for Cough Suppression During Flexible Bronchoscopy
Status: NOT_YET_RECRUITING
Conditions: Subjects Undergoing Flexible Bronchoscopy
Interventions: DRUG: Glycopyrronium|DRUG: Ipratropium|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Carboplatin and Gemcitabine Plus Bevacizumab in Patients With Ovary, Peritoneal, or Fallopian Tube Carcinoma
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Carboplatin|DRUG: Gemcitabine|DRUG: Bevacizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact Of Text Message (SMS) Reminders On Helmet Use Among Motorcycle Drivers In Dar Es Salaam, Tanzania
Status: COMPLETED
Conditions: Road Traffic Injury Prevention|Helmet Use|mHealth Intervention
Interventions: BEHAVIORAL: SMS message reminder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficacy of a Two-week EMST on Dysphagia in Parkinsonian Patients
Status: RECRUITING
Conditions: Parkinson Disease|Multiple System Atrophy|Progressive Supranuclear Palsy
Interventions: DEVICE: expiratory muscle strentgh training (EMST)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Trough Level- and Clinical-based Spacing of Infliximab Infusions in Patients With IBD in Deep Remission
Status: TERMINATED
Conditions: Inflammatory Bowel Diseases
Interventions: OTHER: clinically-based spacing strategy|OTHER: Trough level-based strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Erenumab - Comprehensive Assessment of Efficacy in (High-Frequency) Episodic Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Erenumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Selinexor and Backbone Treatments of Multiple Myeloma Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Selinexor|DRUG: Dexamethasone|DRUG: Lenalidomide|DRUG: Pomalidomide|DRUG: Bortezomib|DRUG: Daratumumab|DRUG: Carfilzomib|DRUG: Ixazomib|DRUG: Elotuzumab|DRUG: Clarithromycin|DRUG: Belantamab Mafodotin|DRUG: Mezigdomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neo-TACE-HAIC for High-risk BCLC A Stage HCC (NeoconceptA)
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: neo-TACE-HAIC+Surgery|PROCEDURE: Surgery alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The PARTNER II Trial: Placement of AoRTic TraNscathetER Valves - PII B
Status: COMPLETED
Conditions: Severe|Symptomatic|Calcific Aortic Stenosis
Interventions: DEVICE: TAVR Implantation with SAPIEN XT|DEVICE: TAVR Implantation with SAPIEN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Precision-Based Approach to Matching Evidence-Based Interventions to Students With Externalizing Behaviors
Status: COMPLETED
Conditions: Problem;Behaviour;Child
Interventions: BEHAVIORAL: Student Intervention Matching System (SIMS)|BEHAVIORAL: group-based social skills training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Linagliptin on Insulin Sensitivity and Pancreatic Beta Cell Function in Patients With Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus|Insulin Sensitivity/Resistance
Interventions: DRUG: Linagliptin|DRUG: Placebo|DRUG: Voglibose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PTX-COVID19-B, an mRNA Humoral Vaccine, Intended for Prevention of COVID-19 in a General Population. This Study is Designed to Demonstrate the Safety, Tolerability, and Immunogenicity of PTX-COVID19-B in Comparison to the Pfizer-BioNTech COVID-19 Vaccine.
Status: COMPLETED
Conditions: Covid19 Vaccine
Interventions: BIOLOGICAL: PTX-COVID19-B|BIOLOGICAL: Pfizer-BioNTech COVID-19 vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Using a Theory-based SMS/VM Intervention to Improve Sexual and Reproductive Health of Female Entertainment Workers in Cambodia
Status: UNKNOWN
Conditions: Reproductive Health|Sexual Health
Interventions: OTHER: Automated text and voice messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase 1 Dose Escalating Trial of Bortezomib in Combination With Lenalidomide in Patients With Myelodysplasia
Status: COMPLETED
Conditions: Myelodysplasia
Interventions: DRUG: Bortezomib|DRUG: Bortezomib|DRUG: Bortezomib|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Premature Ovarian Insufficiency
Status: UNKNOWN
Conditions: Premature Ovarian Insufficiency
Interventions: PROCEDURE: transplantation of human UC-MSCs into ovaries of POI patients|DRUG: hormone replacement treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Recrudescence of Eating Conduct Disorders and Covid-19
Status: ACTIVE_NOT_RECRUITING
Conditions: Psychiatric Disorder|Eating Disorders in Adolescence|COVID-19
Interventions: BEHAVIORAL: Self-questionnaire Eating Attitudes|BEHAVIORAL: Situational Anxiety and Trait Anxiety|BEHAVIORAL: Beck Depression Inventory (BDI) scale|BEHAVIORAL: • Post-traumatic Check List Scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study To Assess Local Tolerability of Crisaborole 2% Ointment and Vehicle Ointment In Healthy Participants Using Subject-reported Assessments and Objective Measurements
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Within-Subject Active vs Placebo Topical Applications|DRUG: Within-Subject Active vs. Placebo Topical Applications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: High-Dose (HD) Methotrexate (MTX) Induction Chemotherapy Followed by Alternative HD MTX-based and HD Cytarabine-based Combination Consolidation Chemotherapy for Newly Diagnosed Primary CNS Lymphoma; CISL 10-01 Study
Status: COMPLETED
Conditions: CNS Lymphoma
Interventions: DRUG: MTX, MVD, VIA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Acellular Dermal in the Incarcerated Inguinal Hernia Tension-free Reconstructions
Status: UNKNOWN
Conditions: Incarcerated Inguinal Hernia
Interventions: PROCEDURE: ADM tension-free hernia reparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antireflux Ablation Therapy (ARAT) Vs Antireflux Mucosectomy (ARMS) In The Management Of Gastroesophageal Reflux Disease
Status: UNKNOWN
Conditions: Gastroesophageal Reflux Disease
Interventions: PROCEDURE: Ablation of the gastroesophageal junction with hybrid argon plasma|PROCEDURE: mucosectomy with band of the gastroesophageal junction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Efficacy, Tolerability, and Safety of a Fixed Dose Combination of Spironolactone, Pioglitazone & Metformin (SPIOMET) in Polycystic Ovary Syndrome (PCOS)
Status: RECRUITING
Conditions: Polycystic Ovary Syndrome (PCOS)
Interventions: DRUG: Placebo|DRUG: Pioglitazone|DRUG: Spironolactone|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Silymarin for Patients With Chronic Hepatitis C Who Have Failed Conventional Antiviral Treatment
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Silymarin|DRUG: Silymarin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interscalene Block Versus Combined Supraprascapular: Axillary Nerve Blocks
Status: COMPLETED
Conditions: Analgesia|Diaphragm
Interventions: PROCEDURE: Interscalene brachial plexus block|PROCEDURE: Supraclavicular-axillary nerve blocks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Allogeneic CD19 CAR-T Cells for the Treatment of Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia
Status: UNKNOWN
Conditions: Relapse Leukemia|Refractory Leukemia
Interventions: BIOLOGICAL: Allogeneic CD19 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Angiotensin-II Receptor Antibodies Blockade With Losartan in Patients With Lupus Nephritis
Status: UNKNOWN
Conditions: Atherosclerosis|Lupus Nephritis
Interventions: DRUG: Losartan|DRUG: Enalapril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Two-level ESPB in Total Knee Arthroplasty
Status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis|Knee Pain Chronic|Knee Arthritis
Interventions: DRUG: 20 ml of Ropivacaine 0.2% Injectable Solution|DRUG: 2 x 20ml of Ropivacaine 0.2% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of HHPG-19K Injection and Auto-HHPG-19K Injection in Prevention of Chemotherapy-related Moderate to Severe Neutropenia of Patients With Nonmyeloid Malignancies
Status: NOT_YET_RECRUITING
Conditions: Patients With Nonmyeloid Malignancies Receiving Antineoplastic Therapy Based on Chemotherapy Regimens at Moderate to High Febrile Neutropenia (FN) Risk
Interventions: DRUG: HHPG-19K Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Bluetooth Haptics Device Distraction on Mechanical Pain Thresholds Induced by PinPrick Stimulators
Status: RECRUITING
Conditions: Pain|Anxiety
Interventions: BEHAVIORAL: Bluetooth Haptic Device (Experimental Frequency) + Needle Sham only|BEHAVIORAL: Bluetooth Haptic Device (Control Frequency) + Needle Sham only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tranexamic Acid Reduce Blood Loss in Meningioma Resection
Status: UNKNOWN
Conditions: Meningioma
Interventions: DRUG: Tranexamic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Double Blind, Placebo-controlled, Study of the Safety, Tolerability and Pharmacokinetics of AIN457 in Rheumatoid Arthritis Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: AIN457|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Favorable-Risk Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: DRUG: Stanford V Chemotherapy|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Biomarkers to Guide Management of Patients Treated With Radiofrequency Ablation for Early Oesophageal Neoplasia
Status: RECRUITING
Conditions: Barrett's Oesophagus
Interventions: DIAGNOSTIC_TEST: Cytosponge test|DIAGNOSTIC_TEST: Assessment of the panel of molecular biomarkers: IM-SCORE, TFF3 protein expression, methylation panel, p53 mutation|DIAGNOSTIC_TEST: Oesophagogastroduodenoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Does Dexamethasone Administration Improve Recovery In Patients Undergoing Minimally Invasive Sacrocolpopexy?
Status: WITHDRAWN
Conditions: Quality of Life|Pelvic Organ Prolapse|Prolapses, Vaginal Vault
Interventions: DRUG: Dexamethasone|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Black Youth M.A.T.T.E.R: Positive Youth Development Group Intervention
Status: UNKNOWN
Conditions: Depression, Anxiety
Interventions: BEHAVIORAL: Black Youth M.A.T.T.E.R.: Molding Young Advocates While Transforming the School to Prison Pipeline Through Psychological Services Education and Resilience
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of 3% Kanuka Oil Versus 1% Hydrocortisone Cream in Patients With Atopic Dermatitis
Status: RECRUITING
Conditions: Dermatitis, Atopic|Pruritus
Interventions: OTHER: 3% kanuka oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LX211 in Clinically Quiescent Non-infectious Intermediate, Anterior and Intermediate, Posterior or Pan-Uveitis
Status: COMPLETED
Conditions: Uveitis, Posterior|Uveitis, Intermediate|Panuveitis
Interventions: DRUG: Placebo|DRUG: LX211|DRUG: LX211|DRUG: LX211
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Two Different Methods to Reduce Intramusculer Injection Pain
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Cryos REF 0971 Cold Spray|DEVICE: ShotBlocker BIONIX Press Firmly USA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ABI-007 in Treating Patients With Inoperable Locally Recurrent or Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: DRUG: paclitaxel albumin-stabilized nanoparticle formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Oral Corticosteroid Therapy in Recurrent Paralyzes After Thyroidectomy
Status: UNKNOWN
Conditions: Recurrent Paralysis of Vocal Cords
Interventions: DRUG: Corticoids|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Montelukast in Exercise-Induced Bronchospasm - 2004 (0476-275)
Status: COMPLETED
Conditions: Asthma, Exercise-Induced
Interventions: DRUG: Comparator: Montelukast|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Investigational Performance Evaluation of the Nanomix eLab® COVID-19 Rapid Antigen Panel With Samples From COVID-19 Positive and Negative Human Subjects
Status: COMPLETED
Conditions: Covid19
Interventions: DIAGNOSTIC_TEST: Nanomix eLab® COVID-19 Rapid Antigen Panel (non-interventional)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Anemia in Patients With Very Low, Low or Intermediate Risk Myelodysplastic Syndromes With CA-4948
Status: TERMINATED
Conditions: Myelodysplastic Syndromes|Anemia
Interventions: DRUG: CA-4948
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Study the Effect of Aprocitentan on the Electrical Activity of the Heart in Healthy Men and Women
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Aprocitentan 25 mg|DRUG: Aprocitentan 100 mg|DRUG: Matching placebo|OTHER: Moxifloxacin control to establish assay sensitivity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors
Status: NOT_YET_RECRUITING
Conditions: Recurrent Cancer|Prostate Cancer|Cervical Cancer|Anal Cancer|Sarcoma|Rectal Cancer|Neuroendocrine Tumors|Esophageal Cancer|Pancreas Cancer|Squamous Cell Carcinoma
Interventions: DEVICE: loco-regional hyperthermia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FreeStyle Libre FGM During Summer Camp for Children With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Hypoglycemia|Hyperglycemia
Interventions: DEVICE: FreeStyle Libre FGM|DEVICE: SMBG - Blinded Sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety of DERMASEAL for Diabetic Foot Ulcers
Status: RECRUITING
Conditions: Foot Ulcer, Diabetic
Interventions: COMBINATION_PRODUCT: DERMASEAL|BIOLOGICAL: Plasma Film|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Phase 1 Dose Escalation and Expansion Study Of SHR7280 In Subjects With Hormone Sensitive Prostate Cancer
Status: COMPLETED
Conditions: Hormone Sensitive Prostate Cancer
Interventions: DRUG: SHR7280
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Low Level Laser Therapy (LLLT) Effective for Reducing Pain Experienced by Women With Provoked Vestibulodynia?
Status: COMPLETED
Conditions: Provoked Vestibulodynia
Interventions: OTHER: Low Level Laser Therapy|OTHER: Sham Low Level Laser Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radioimmunotherapy With Lu-177 Labeled 6A10 Fab-fragments in Patients With Glioblastoma After Standard Treatment
Status: RECRUITING
Conditions: Glioblastom WHO Grade 4
Interventions: DRUG: Lu-177 labeled 6A10-Fab-fragments
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of NNZ-2566 in Healthy Subjects, Following Oral Administration
Status: COMPLETED
Conditions: Brain Injuries, Traumatic
Interventions: DRUG: NNZ-2566|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Combination of Cetuximab and Methotrexate in Recurrent or Metastatic Cancer of the Head and Neck
Status: UNKNOWN
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Cetuximab|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Retrospective Comparison Between CPS and HC Techniques for Osteoporotic Fractures in the Thoracic or Lumbar Spine
Status: UNKNOWN
Conditions: Osteoporosis
Interventions: PROCEDURE: Cement-augmented Pedicle Screws (CPS)|PROCEDURE: Hybrid Construct (HC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RM-493 Administered to Healthy, Obese, Non-diabetic Volunteers
Status: COMPLETED
Conditions: Overweight|Obese
Interventions: DRUG: RM-493|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Native-Changing High-risk Alcohol Use and Increasing Contraception Effectiveness Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Contraceptive Usage|Alcohol Use Complicating Childbirth|Alcohol Drinking
Interventions: BEHAVIORAL: Native-CHOICES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Positron Emission Tomography (PET) Trial to Evaluate Target Occupancy of CVL-354 at Kappa and Mu Opioid Receptors in Brain Following Oral Dosing
Status: COMPLETED
Conditions: Opioid Use Disorder
Interventions: DRUG: CVL-354|DRUG: [11C]-LY2795050|DRUG: [11C]-carfentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Probiotics as Adjunct Therapy Along With Standard Care in Decreasing Hospital Stay and Improving Symptoms in Pediatric Patients Admitted With Severe Pneumonia
Status: RECRUITING
Conditions: Pneumonia|Probiotics
Interventions: DIETARY_SUPPLEMENT: probiotic containing Lactobacillus rhamnosus GG.|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mindful Yoga Therapy as an Adjunctive Treatment for PTSD Among OEF/OIF Veterans
Status: WITHDRAWN
Conditions: PTSD
Interventions: BEHAVIORAL: Mindful Yoga Therapy|BEHAVIORAL: Wait-list Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BioFreedom US IDE Feasibility Trial
Status: UNKNOWN
Conditions: Ischemic Heart Disease|Stable Angina|Unstable Angina|Silent Ischemia
Interventions: DEVICE: BioFreedom drug coated coronary stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gene-guided Warfarin for Anticoagulation Therapy
Status: WITHDRAWN
Conditions: Stroke
Interventions: DEVICE: Gene detection (CYP2C9*3, VKORC1)|DRUG: Warfarin Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Ezetimibe Utilization Early After Acute Myocardial Infarction, "EzAMI Trial"
Status: RECRUITING
Conditions: Acute Myocardial Infarction|Dyslipidemias
Interventions: DRUG: Ezetimibe 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Copper-64 SAR Bombesin in PSMA Negative Prostate Cancer (BOP)
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Copper-64 labelled SAR-Bombesin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neuroprotective Effect of Dexomitomidine
Status: UNKNOWN
Conditions: Dexmedetomidine Neuroprotective Effect in Traumatic Brain Injury
Interventions: DRUG: Dexmedetomidine|DRUG: placebo salin infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Safety Extension Study to Evaluate the Safety and Tolerability of Benralizumab (MEDI-563) in Asthmatic Adults and Adolescents on Inhaled Corticosteroid Plus LABA
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: Benralizumab|BIOLOGICAL: Benralizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Solutions Used in Oral Care on Preventing Ventilator-Associated Pneumonia.
Status: NOT_YET_RECRUITING
Conditions: Ventilator-Associated Pneumonia
Interventions: OTHER: Use of oral care solutions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Immunotherapy of Stage III/IV Melanoma Patients
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: Melan-A ELA + Montanide|BIOLOGICAL: Melan-A ELA + NY-ESO-1b + MAGE-A10 + Montanide|BIOLOGICAL: Melan-A -ELA + NY-ESO-1b + MAGE-A10 peptide + Montanide + CpG|BIOLOGICAL: Melan-A-EAA/ELA + NY-ESO-1 lp + MAGE-A10 + Montanide + CpG|BIOLOGICAL: Melan-A-EAA/ELA + NY-ESO-1 lp + MAGE-A10 + Montanide + CpG+ IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Efficacy of SelK2 on Airway Responses Following Allergen Challenge in Subjects With Asthma (Part 1) and in Subjects With Chronic Obstructive Pulmonary Disease (Part 2)
Status: COMPLETED
Conditions: Asthma|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: SelK2 (Part 1)|DRUG: Placebo (Part 1)|DRUG: SelK2 (Part 2)|DRUG: Placebo (Part 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Venetoclax, Hypomethylation Agent and Low-dose Cytarabine as a Salvage Therapy for Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Relapsed Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia|Minimal Residual Disease
Interventions: DRUG: Venetoclax, Decitabine, Azacytidine, Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hepatic Dysfunction, Vitamin D Status, and Glycemic Control in Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes|Nonalcoholic Fatty Liver Disease|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Ergocalciferol, placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Pain, Anxiety and Fatigue and Knee Position Sense, Balance and Dual Task Performance During Menstrual Cycle in Females With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Menstrual Pain|Anxiety|Fatigue|Neurologic Symptoms
Interventions: OTHER: pain|OTHER: fatigue|OTHER: anxiety|OTHER: position sense|OTHER: balance|OTHER: dual task performance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of the Non-invasive Approach and Fetal Exome Sequencing in Prenatal Diagnosis When Fetal Ultrasound Signs Are Discovered
Status: RECRUITING
Conditions: Antenatal Congenital Malformations
Interventions: OTHER: Collection of clinical data|BIOLOGICAL: Collection of samples|OTHER: Questionnaires|OTHER: Parent interviews|OTHER: Professional interview and focus groups
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: To Evaluate the Blood Levels and Safety of IV and Subcutaneous CDP6038 in Subjects With Rheumatoid Arthritis Using Methotrexate
Status: COMPLETED
Conditions: Arthritis|Rheumatoid Arthritis
Interventions: BIOLOGICAL: CDP6038|BIOLOGICAL: CDP6038|BIOLOGICAL: CDP6038|OTHER: Placebo IV|OTHER: Placebo SC|DRUG: CDP 6038 SC|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Daratumumab, Azacitidine, and Dexamethasone for Treatment of Patients With Recurrent or Refractory Multiple Myeloma Previously Treated With Daratumumab
Status: TERMINATED
Conditions: Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: DRUG: Azacitidine|BIOLOGICAL: Daratumumab|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Enhancin[Co-amoxiclav] Versus Postoperative Enhancin in Prevention of Postadenotonsillectomy Morbidity.
Status: COMPLETED
Conditions: Adenotonsillar Hypertrophy,Under 12 Years.
Interventions: DRUG: Enhancin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Role of Push Enteroscopy in Patients With Passing Melena With Nondiagnostic EGD.
Status: COMPLETED
Conditions: Melena Due to Gastrointestinal Hemorrhage
Interventions: DIAGNOSTIC_TEST: Push enteroscopy (PE)|DIAGNOSTIC_TEST: Colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Exercise on Blood Glucose Levels in Patients With Type 1 Diabetes: A Comparison of 3 Long-acting Insulins
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin detemir|DRUG: insulin glargine|DRUG: insulin NPH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First Trimester Placental Assessment in the Screening of Preeclampsia and Intrauterine Growth Restriction
Status: COMPLETED
Conditions: Preeclampsia|Intrauterine Growth Restriction
Interventions: OTHER: Ultrasound study of the placenta|OTHER: Measurement of angiogenic and anti-angiogenic factors (sFlt-1 and PlGF) in the first trimestre blood test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating and Implementing a Smartphone Application Treatment Program for Bulimia Nervosa and Binge Eating Disorder
Status: WITHDRAWN
Conditions: Eating Disorder|Bulimia Nervosa|Binge Eating Disorder
Interventions: BEHAVIORAL: Adaptive Recovery Record App|BEHAVIORAL: Standardized Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Mechanical Thrombectomy in Acute Ischemic Stroke Related to a Distal Arterial Occlusion
Status: RECRUITING
Conditions: Acute Ischemic Stroke (AIS) Related to a Distal Occlusion
Interventions: PROCEDURE: Mechanical Thrombectomy|DRUG: Best medical treatment alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inguinal Hernia Treatment: Stationary/Inpatient vs. Ambulatory/Outpatient Setting - HerStAmb Study
Status: COMPLETED
Conditions: Outcome of Outpatient/Ambulatory and Inpatient/Stationary Setting
Interventions: PROCEDURE: inguinal hernia repair
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized Controlled Trial:High-flow Oxygen Therapy and Tracheal Intubation for Laryngeal Microsurgery
Status: RECRUITING
Conditions: Laryngeal Disease
Interventions: DEVICE: THRIVE|DEVICE: mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Moexipril HCL/Hydrochlorothiazide 15/25 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Moexipril HCl/hydrochlorothiazide 15/25 mg tablets|DRUG: UNIRETIC® 15/25 mg tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of SPH3127 in Patients With Mild-to-Moderate Ulcerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: SPH3127|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-traumatic Stress Injuries Among Paramedics and Emergency Dispatchers
Status: UNKNOWN
Conditions: Stress Disorders, Post-Traumatic|Acute Stress Disorder|Anxiety Disorders|Depressive Disorder|Substance Abuse|Absenteeism
Interventions: OTHER: Psychological first aid|OTHER: Usual organisational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Use of a Liquid Supplement Containing 2 Human Milk Oligosaccharides (HMOs) in Preterm Infants
Status: COMPLETED
Conditions: Premature Infant
Interventions: DIETARY_SUPPLEMENT: HMO supplement|DIETARY_SUPPLEMENT: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Transcranial Direct Current Stimulation (tDCS) on Appetite Control Related Brain Regions
Status: COMPLETED
Conditions: Obesity
Interventions: DEVICE: tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interest of Salivary Signature of Endometriosis in the Heathcare Pathway of Adolescent
Status: RECRUITING
Conditions: Endometriosis
Interventions: DEVICE: in vitro diagnostic medical device|BEHAVIORAL: Completion of a self-questionnaire|DEVICE: in vitro diagnostic medical device
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Severe Immune Cytopenia Registry Www.Sic-reg.Org
Status: ACTIVE_NOT_RECRUITING
Conditions: Immune Thrombocytopenia|Autoimmune Hemolytic Anemia|Evans Syndrome|Primary Immunodeficiency
Interventions: DIAGNOSTIC_TEST: potential biomarkers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Genasense, Carboplatin, Paclitaxel (GCP) Combination in Uveal Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: Genasense|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Trial of Myeloablative Conditioning w/ Clofarabine and HD Busulfan for Pts w/ Refractory Heme Malignancies Undergoing Allo PBSCT
Status: COMPLETED
Conditions: Hematologic Malignancies
Interventions: DRUG: clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Keluo Xin Capsule Compare to Placebo in Terms of Efficacy and Safety in Patients With Diabetic Retinopathy
Status: UNKNOWN
Conditions: Moderately Severe to Severe NPDR
Interventions: DRUG: Keluo Xin capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Kinesio® Tex Application on Pain, Functionality, Sleep Quality and Work Performance in Drivers
Status: COMPLETED
Conditions: Neck Pain|Back Pain|Occupational Diseases
Interventions: OTHER: exercise|OTHER: taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise Training in Treating Diastolic Heart Failure
Status: WITHDRAWN
Conditions: Heart Failure, Diastolic|Ventricular Dysfunction, Left
Interventions: BEHAVIORAL: High intensity endurance exercise|BEHAVIORAL: Moderate continuous endurance exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Method for Treating Lung Met w/Combo of Electric Fields & Rad Therapy: A Single-Arm
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Tumor|Metastatic Cancer
Interventions: PROCEDURE: Irreversible electroporation (IRE) ablation|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Ranging Study to Assess the Efficacy and Safety of Acitretin in Severe Plaque Type Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Acitretin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Daclizumab and Anti-Thymocyte Globulin in Lung Transplantation
Status: COMPLETED
Conditions: Patients Active and Listed for Lung Transplantation
Interventions: DRUG: Zenapax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bern Birth Cohort / Trajectory of Microbiota Maturation in Healthy Bern Infants - a Network Approach
Status: RECRUITING
Conditions: Maturation of the Healthy Infant Intestinal Microbiota|Microbial Colonization|Nutrition Disorder, Infant|Milk Expression, Breast|Mental Health Disorder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Allo Non-myeloablative SCT Utilizing Matched Family Member Stem Cells Purged Using Campath
Status: COMPLETED
Conditions: Lymphoma|Myeloma|Leukemia|Myelodysplasia|Solid Tumors
Interventions: DRUG: Campath Purged Non-myeloablative ASCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Single Lung Transplant (BOSTON-1)
Status: ACTIVE_NOT_RECRUITING
Conditions: Bronchiolitis Obliterans|Chronic Rejection of Lung Transplant|Lung Transplant Rejection|Lung Transplant; Complications|Lung Transplant Failure and Rejection|Chronic Lung Allograft Dysfunction
Interventions: DRUG: Liposomal Cyclosporine A|DRUG: standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Hyperbilirubinaemia on Two Different Near Infrared Spectroscopy Devices
Status: COMPLETED
Conditions: Liver Transplant; Complications
Interventions: DEVICE: Near infrared spectroscopy with INVOS device|DEVICE: Near infrared spectroscopy with Foresight device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: To Evaluate the Safety, Efficacy, and Pharmacokinetics of Intravesical Instiliations of Disitamab Vedotin in Patients With High-risk Non-muscular Invasive Bladder Cancer (NMIBC) That Express HER2
Status: RECRUITING
Conditions: High-risk Non-muscle Invasive Bladder Cancer
Interventions: DRUG: Disitamab Vedotin for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Acceptability of Click's EMA and Text Message Intervention for STRESS Management
Status: COMPLETED
Conditions: Stress, Psychological|Loneliness|Covid19|Stress
Interventions: DEVICE: EMA + Automated Text Message Intervention|BEHAVIORAL: EMA Alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study Evaluating the Absorption Of Varenicline Through The Skin Following Once Daily Application Of A Patch For 14 Days
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: varenicline free base patch|DRUG: varenicline free base patch|DRUG: placebo patch|DRUG: varenicline free base patch|DRUG: placebo patch|DRUG: varenicline free base patch|DRUG: placebo patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of the DYNAtraq Device to Prevent Complications in Tracheostomy in Mechanically Ventilated Patients
Status: COMPLETED
Conditions: Tracheostomy|Mechanical Ventilation Complication
Interventions: DEVICE: DYNAtraq
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Effect of Pasteurized Akkermansia Muciniphila (pAkk) on Complaints Related to IBS
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: pasteurized A. muciniphila|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine vs Placebo for Pediatric Cleft Palate Repair
Status: WITHDRAWN
Conditions: Cleft Palate
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biobank for "Arrhythmia and Conduction Disorders: TowArd Pathophysiology Based Treatment"
Status: RECRUITING
Conditions: Arrythmia|Conduction Disorder|Pathophysiology
Interventions: OTHER: Biobank for Left atrial appendage tissue|OTHER: Biobank for Blood|OTHER: Biobank for One or more of following fat patches: epicardial fat, subcutaneous fat, pericardial fat, visceral fat.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multimodal Analysis of the Young Brain on Rhythm Perception: From Premature Neonates to Infants
Status: RECRUITING
Conditions: Time Perception|Rhythm|EEG|fNIRS|ERP|Premature Neonates|Discrimination
Interventions: OTHER: EEG|OTHER: NIRS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: An Investigational Drug Study to Assess Weight Loss in Patients With Type 2 Diabetes Mellitus (0364-011)(TERMINATED)
Status: TERMINATED
Conditions: Obesity Type 2 Diabetes Mellitus|Type 2 Diabetes Mellitus
Interventions: DRUG: Taranabant|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Safety and Effectiveness of Two Dosing Schedules of Lamivudine in Combination With Two Other Anti-HIV Drugs
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Nelfinavir mesylate|DRUG: Lamivudine|DRUG: Stavudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of VS-6766 and Cetuximab in Patients With Advanced Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer|Colorectal Adenocarcinoma|Colorectal Cancer Metastatic|Advanced Colorectal Carcinoma|Advanced Colorectal Adenocarcinoma
Interventions: DRUG: VS-6766/avutometinib|DRUG: Cetuximab|OTHER: Pill Diary
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integral Physiological Adaptations to Carbohydrate Periodization
Status: COMPLETED
Conditions: Sleepiness|Fatigue|Feeding Patterns|Daytime Sleepiness, Excessive
Interventions: BEHAVIORAL: Evening LGI Carbohydrate Consumption Group|BEHAVIORAL: Evening HGI Carbohydrate Consumption|BEHAVIORAL: Evening NO-CHO Carbohydrate Consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test
Status: COMPLETED
Conditions: Healthy|Adrenal Insufficiency|Hypopituitarism
Interventions: DRUG: Synacthen (Tetracosactrin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC