pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Trial to Learn if Single Ascending Intravenous (IV) Doses of REGN7508 Are Safe and Well Tolerated, and How it Works in the Body of Healthy Adult Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Volunteer
Interventions: DRUG: REGN7508 (IV)|DRUG: REGN7508 (SC)|DRUG: Matching Placebo (IV)|DRUG: Matching Placebo (SC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Registry Study to Observe Clinical Outcomes of Participants With High-risk Metastatic Hormone-naïve Prostate Cancer in Japan
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostatic Neoplasms
Interventions: DRUG: Androgen-deprivation Therapy (ADT)|DRUG: Bicalutamide|DRUG: Abiraterone|DRUG: Prednisolone|DRUG: Docetaxel|DRUG: Enzalutamide|DRUG: Apalutamide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunogenicity, Safety, and Tolerability of an MF59-Adjuvanted Versus Non-Adjuvanted Influenza Vaccines in Patients With Chronic Pulmonary Disease, Chronic Heart Disease, or Diabetes Mellitus
Status: COMPLETED
Conditions: H1N1 Influenza Virus|Chronic Pulmonary Disease|Chronic Heart Disease|Diabetes Mellitus
Interventions: BIOLOGICAL: Focetria®|BIOLOGICAL: Fluad®|BIOLOGICAL: Begrivac®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Automated Oxygen Delivery by O2matic to Patients Admitted With an Exacerbation in COPD
Status: COMPLETED
Conditions: COPD Exacerbation|Hypoxia|Hyperoxia|Respiratory Failure|Respiratory Insufficiency|Copd Exacerbation Acute
Interventions: DEVICE: O2matic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Acetylsalicylic acid|DRUG: Rivaroxaban|DRUG: Clopidogrel|DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Decompensated HCV Cirrhotic Patients
Status: COMPLETED
Conditions: Decompensated Cirrhosis
Interventions: DRUG: Sofosbuvir 400mg (Sovaldi) + Daclatasvir 60 mg (Daklinza) + Ribavirin 200 mg (Rebetol)|DRUG: vitamin K (Phytomenadione) 10 mg+ furosemide and spironolactone (Lasilactone) 50 mg + milk thistle (Silymarin) 140 mg + Albumin infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-Guided Continuous Serratus Anterior Plane Block vs Dexmedetomidine Infusion in Patients With Rib Fractures.
Status: RECRUITING
Conditions: Pain
Interventions: PROCEDURE: Ultrasound-guided continuous serratus anterior plane block|DRUG: intravenous dexmedetomidine infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exploring the Safety And Tolerability of Doses of E2007 up to a Maximum of 12 mg In Patients With Refractory Partial Seizures
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: E2007|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clascoterone for Steroid-related Acne Vulgaris in Transgender Male Patients Receiving Masculinizing Hormone Therapy
Status: RECRUITING
Conditions: Acne Vulgaris
Interventions: DRUG: Clascoterone 1% Top Cream|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Pharmacokinetics of BAT2022 in Healthy Chinese Subjects
Status: COMPLETED
Conditions: SARS-CoV-2 Infection
Interventions: DRUG: BAT2022
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Low-dose Irinotecan and Cyberknife® SBRT to Treat Colorectal Cancer With Limited Liver Metastasis
Status: WITHDRAWN
Conditions: Colorectal Cancer
Interventions: DRUG: Irinotecan|RADIATION: CyberKnife
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Research on the Effects of Combined Neurostimulation Protocols on Stress
Status: COMPLETED
Conditions: Stress Reaction|Stress Related Disorder|Major Depressive Disorder
Interventions: DEVICE: active tDCS|DEVICE: sham tDCS|DEVICE: iTBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Impact of Nutrition Intervention on HIV/AIDS Infected Patients
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV)|Acquired Immune Deficiency Syndrome (AIDS)
Interventions: DIETARY_SUPPLEMENT: Theragran-M; Ensure Plus|DIETARY_SUPPLEMENT: Theragran-M
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Afamelanotide and Narrow-Band Ultraviolet B (NB-UVB) Light in the Treatment of Nonsegmental Vitiligo (NSV)
Status: COMPLETED
Conditions: Vitiligo
Interventions: DRUG: Afamelanotide|PROCEDURE: Narrow-Band UVB Light Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, & Pharmacokinetics of Candesartan Cilexetil in Hypertensive Paediatric Subjects 6 to < 17 Years of Age
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: candsartan cilexetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Study the Absorption, Metabolism, and Excretion of [14C]-Praliciguat in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: [14C]-praliciguat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Prospective, Randomized TrialComparing Oral N-Acetylcysteine and Intravenous Sodium Bicarbonate
Status: TERMINATED
Conditions: Nephropathy
Interventions: DRUG: Oral N-Acetylcysteine|DRUG: Sodium Bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Extension to CQTI571A2102 to Evaluate Long-term Safety, Tolerability and Efficacy of Imatinib in Severe Pulmonary Arterial Hypertension (PAH)
Status: TERMINATED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alveolar Ridge Preservation Using Autogenous Tooth Graft Versus Autogenous Demineralized Dentin Graft.
Status: COMPLETED
Conditions: Alveolar Ridge Preservation|Dentin Graft|Autogenous Tooth Bone Graft
Interventions: PROCEDURE: Alveolar ridge preservation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intratumoral Injection of Dengue Virus-1 #45AZ5 (PV-001-DV) in Patients With Melanoma
Status: NOT_YET_RECRUITING
Conditions: Advanced Melanoma
Interventions: BIOLOGICAL: Dengue Virus-1 #45AZ5 (PV-001-DV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Therapeutic Effect of TCM Treatment for MDR MN
Status: UNKNOWN
Conditions: Idiopathic Membranous Nephropathy
Interventions: DRUG: Jianpixiaozhong particles and Wuse Dietotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Safety and Efficacy of Adding Sitagliptin in Patients With Type 2 Diabetes Mellitus (MK0431-074)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Comparator: Sitagliptin phosphate|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Total Neoadjuvant Therapy for High-risk Locally Advanced Rectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Rectal Cancer
Interventions: COMBINATION_PRODUCT: Concurrent Chemoradiotherapy|DRUG: XELOX|DRUG: mFOLFOX|PROCEDURE: TME
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Return of Function and External Rotation Post Proximal Humerus Fracture Fixation With Neutral Rotation Brace
Status: TERMINATED
Conditions: Proximal Humeral Fracture
Interventions: PROCEDURE: Operative procedure to fix proximal humeral|DEVICE: Neutral Rotation Brace|OTHER: Physiotherapy review|OTHER: Functional outcome forms filled in|OTHER: Postal functional outcome scores|OTHER: Post-operative Radiographs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Low Dose Daily Erlotinib in Combination With High Dose Twice Weekly Erlotinib in Patients With EGFR-Mutant Lung Cancer
Status: COMPLETED
Conditions: EGFR-Mutant Lung Cancer
Interventions: DRUG: erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation of Teleophthalmology in Urban Health Systems Study
Status: ENROLLING_BY_INVITATION
Conditions: Diabetic Retinopathy
Interventions: OTHER: I-SITE Intervention|OTHER: Usual Care Teleophthalmology
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Dose Proportionality Study Of PF-00345439 Formulation Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxycodone|DRUG: Oxycodone|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study in Men With Low Testosterone to Measure the Effects of Testosterone Solution on Testosterone Levels, Sex Drive and Energy
Status: COMPLETED
Conditions: Hypogonadism
Interventions: DRUG: Testosterone Solution|DRUG: Placebo Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ilioinguinal Iliohypogastric Nerve Block as Adjunct to Spinal Anesthesia for Cesarean Section
Status: COMPLETED
Conditions: Cesarean Section|Post Operative Pain
Interventions: OTHER: ilio-inguinal/ilio-hypogastric nerve block (IINB)|OTHER: intrathecal morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modified Extension Study to the SUmiT Trial: Evaluation of Long Term Therapy With Percutaneous Tibial Nerve Stimulation (PTNS) for Overactive Bladder Symptoms
Status: COMPLETED
Conditions: Urinary Bladder, Overactive
Interventions: DEVICE: Urgent PC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Immune Therapy, Durvalumab (MEDI4736) With Tremelimumab for Metastatic, Non-transitional Cell Carcinoma of the Urinary Tract
Status: COMPLETED
Conditions: Non-Transitional Cell Carcinoma of the Urothelial Tract|Small Cell of the Bladder|Adenocarcinoma of the Bladder|Squamous Cell Carcinoma of the Bladder|Metastatic Bladder Cancer
Interventions: DRUG: durvalumab and tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of a Non-Invasive Neuromodulation Device for Treatment of Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DEVICE: TNM (trade name), a form of brainstem Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Ruxolitinib Plus Simvastatin in the Prevention and Treatment of Respiratory Failure of COVID-19.
Status: COMPLETED
Conditions: Coronavirus Infection
Interventions: DRUG: Ruxolitinib plus simvastatin|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System
Status: TERMINATED
Conditions: Anxiety|Hypertension
Interventions: DRUG: Clonidine Pill|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of an Exoskeleton Gait Training Versus Manual Therapy in Subacute Post Stroke Patients.
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: Technological Rehabilitation|OTHER: Control Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Pharmacokinetics of RO7223280 in Critically Ill Participants With Bacterial Infections
Status: COMPLETED
Conditions: Bacterial Infections
Interventions: DRUG: RO7223280|DRUG: RO7223280
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Biological Disease Modifying Anti Rheumatic Drug (bDMARD) Treatment on Spinal Fracture Incidence in Patients With Ankylosing Spondylitis (AS)
Status: COMPLETED
Conditions: Ankylosing Spondylitis|Spinal Fractures
Interventions: DRUG: bDMARD treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sugammadex Dosage Based on Ideal Body Weight for Profound Rocuronium-induced Neuromuscular Blockade Reversal in Morbidly Obese Patients
Status: COMPLETED
Conditions: Morbid Obesity
Interventions: DRUG: Sugammadex 1 mg/kg|DRUG: Sugammadex 2 mg/kg|DRUG: Sugammadex 4 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Pharmacology of Adjuvant Hormonotherapy in Breast Cancer
Status: COMPLETED
Conditions: Hormono-depending Adjuvant Breast Cancer
Interventions: DRUG: Tamoxifen, Letrozole, Anastrozole or Exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Cancer Lysate Vaccine and Montanide (Registered Trademark) ISA-51 VG With or Without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer
Status: SUSPENDED
Conditions: Non-Small Cell Lung Cancer|Non-Small Cell Lung Carcinoma|Carcinoma, Non-Small-Cell Lung|Carcinomas
Interventions: BIOLOGICAL: Montanide (Registered Trademark) ISA-51 VG Adjuvant|BIOLOGICAL: H1299 Cell Lysates|DRUG: N-803|DEVICE: Ventana PD-L1 (SP263 or SP142) assay
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tumors
Status: RECRUITING
Conditions: Clear Cell Renal Cell Carcinoma|Cervical Carcinoma|Esophageal Carcinoma|Pancreatic Adenocarcinoma|Malignant Pleural Mesothelioma
Interventions: BIOLOGICAL: CTX131
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Multidimensional Rehabilitation in the Metaverse
Status: RECRUITING
Conditions: Colorectal Neoplasms
Interventions: DEVICE: Multidimensional Rehabilitation in the Metaverse
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study to Evaluate CC-486/Onureg in Participants With Moderate or Severe Hepatic Impairment Compared With Normal Hepatic Function in Participants With Myeloid Malignancies
Status: RECRUITING
Conditions: Hepatic Insufficiency|Neoplasms
Interventions: DRUG: Onureg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Toripalimab in Combination With Axitinib in Patients With Localized Mucosal Melanoma
Status: UNKNOWN
Conditions: Mucosal Melanoma
Interventions: DRUG: TORIPALIMAB INJECTION(JS001 ) Axitinib tablet (Inlyta®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Global FKRP Registry
Status: RECRUITING
Conditions: LGMD2I|LGMDR9|Limb Girdle Muscular Dystrophy|Congenital Muscular Dystrophy|Muscle-Eye-Brain Disease|Walker-Warburg Syndrome|FKRP Gene Mutation
Interventions: OTHER: Patient Registry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: BAY 43-9006 (Sorafenib) to Treat Patients With Kaposi's Sarcoma
Status: TERMINATED
Conditions: Kaposi's Sarcoma|HHV-8|KSHV
Interventions: DRUG: BAY 43-9006
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Pseudomonas Aeruginosa Biofilms in Exacerbations in Patients With Bronchiectasis With and Without Chronic Obstructive Pulmonary Disease
Status: UNKNOWN
Conditions: Bronchiectasis|Microbial Colonization|Pseudomonas Aeruginosa|Biofilm
Interventions: DIAGNOSTIC_TEST: Microbial biofilm diagnose
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lapatinib Plus Chemotherapy Versus Trastuzumab Plus Chemotherapy in HER2-positive Breast Cancer
Status: UNKNOWN
Conditions: Neoplasms, Breast
Interventions: DRUG: Lapatinib|BIOLOGICAL: Trastuzumab|DRUG: Paclitaxel|DRUG: Epirubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: How Acupuncture Therapy Improves Dysphagia in Parkinson's Patients
Status: NOT_YET_RECRUITING
Conditions: Dysphagia
Interventions: BEHAVIORAL: Routine rehabilitation training|BEHAVIORAL: Swallowing rehabilitation training|PROCEDURE: Acupuncture therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RAFF4 Trial: Vernakalant vs. Procainamide for Acute Atrial Fibrillation in the Emergency Department
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: Vernakalant|DRUG: Procainamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Application of Combined Optical and Magnetic Stimulation (COMS) for Treatment of Chronic Wounds: Safety Evaluation
Status: COMPLETED
Conditions: Leg Ulcers Venous|Leg Ulcer Arterial|Leg Ulcer Mixed
Interventions: DEVICE: Pio Medical Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of Dyskinesia Rating Scales
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Amantadine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Sonothrombolysis Potentiated by Microbubbles for Acute Ischemic Stroke
Status: COMPLETED
Conditions: Cerebrovascular Stroke
Interventions: OTHER: Sulfur hexafluoride + ultrasounds|DRUG: Recombinant tissue plasminogen activator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Ready-to-Use-Food (RUF) Supplement to Prevent Acute Child Malnutrition
Status: COMPLETED
Conditions: Child|Malnutrition
Interventions: DIETARY_SUPPLEMENT: Plumpy Doz(r) - Ready-to-Use Food|BEHAVIORAL: Food-for-Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Early Postoperative Enteral Immunonutrition in Low-Risk Cardiac Surgery Patients
Status: COMPLETED
Conditions: Cardiac Surgery
Interventions: DIETARY_SUPPLEMENT: Immunonutrients + normal daily meal|DIETARY_SUPPLEMENT: Normal daily meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lymphodreinage Integrated With Kinesio Tape in TKA Patients
Status: COMPLETED
Conditions: TOTAL KNEE ARTHROPLASTY|Edema Secondary|Pain|Joint Dysfunction
Interventions: PROCEDURE: PHYSIOTHERAPY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated Post-prostatectomy Radiotherapy (HYPORT)for Localized Prostate Cancer
Status: RECRUITING
Conditions: Localized Prostate Cancer
Interventions: RADIATION: Conventional radiation therapy|RADIATION: Hypofractionated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bispecific T Cell Engager BRiTE for Patients With Grade IV Malignant Glioma
Status: NOT_YET_RECRUITING
Conditions: Malignant Glioma|Glioblastoma
Interventions: DRUG: hEGFRvIII-CD3 (BRiTE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tissue Samples From Patients With Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: GENETIC: DNA analysis|GENETIC: DNA methylation analysis|GENETIC: RNA analysis|GENETIC: gene expression analysis|GENETIC: polymorphism analysis|OTHER: laboratory biomarker analysis|OTHER: medical chart review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Bosentan in the Treatment of Stable Severe Chronic Obstructive Pulmonary Disease Patients
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Bosentan|DRUG: Symbicort turbuhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cladribine, Idarubicin, Cytarabine, and Venetoclax in Treating Patients With Acute Myeloid Leukemia, High-Risk Myelodysplastic Syndrome, or Blastic Phase Chronic Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Biphenotypic Leukemia|Acute Myeloid Leukemia|Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Blasts 10 Percent or More of Bone Marrow Nucleated Cells|Blasts 10 Percent or More of Peripheral Blood White Cells|de Novo Myelodysplastic Syndrome|Myelodysplastic Syndrome|Previously Treated Myelodysplastic Syndrome|Recurrent Acute Myeloid Leukemia|Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Refractory Acute Myeloid Leukemia|Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Secondary Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: Cladribine|DRUG: Cytarabine|DRUG: Gilteritinib|DRUG: Idarubicin|OTHER: Laboratory Biomarker Analysis|DRUG: Midostaurin|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Crossover Trial of Prophylactic Wilate Compared to Placebo for Heavy Menstrual Bleeding in Patients With VWD
Status: NOT_YET_RECRUITING
Conditions: Von Willebrand Diseases
Interventions: DRUG: Lyophilized concentrate of human coagulation von Willebrand Factor and factor VIII|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Durvalumab|DRUG: Domvanalimab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ORIOn-E: A Study Evaluating CPI-1205 in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: CPI-1205|DRUG: ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-Dose Deferoxamine in Intracerebral Hemorrhage
Status: TERMINATED
Conditions: Intracerebral Hemorrhage
Interventions: DRUG: Deferoxamine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Concurrent Chemoradiotherapy Combined With Sintilimab as Neoadjuvant Therapy for GC Patients With PALM
Status: RECRUITING
Conditions: Gastric Cancer|Gastric Cancer Metastatic to Regional Lymph Nodes
Interventions: DRUG: Sintilimab|RADIATION: Extraperitoneal radiation therapy|DRUG: Oxaliplatin|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Patients With Major Depressive Disorder With MK0869 (0869-061)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: MK0869, aprepitant|DRUG: Comparator: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Agent Obinutuzumab in Relapsed/Refractory Post-Transplant Lymphoproliferative Disorder (PTLD)
Status: WITHDRAWN
Conditions: Post-transplant Lymphoproliferative Disorder|PTLD
Interventions: DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelofibrosis|Primary Myelofibrosis|Post-polycythemia Vera Myelofibrosis|Post-essential Thrombocythemia Myelofibrosis
Interventions: DRUG: Pelabresib|DRUG: Ruxolitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bosentan for Treatment of Hepatopulmonary Syndrome in Patients With Liver Cirrhosis
Status: TERMINATED
Conditions: Hepatopulmonary Syndrome|Liver Cirrhosis
Interventions: DRUG: bosentan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development and EValuation of an Online Intervention to Reduce Self-Stigma in People With Visible Chronic Skin disEases
Status: NOT_YET_RECRUITING
Conditions: Psoriasis|Alopecia Areata|Hidradenitis Suppurativa|Vitiligo|Atopic Dermatitis
Interventions: BEHAVIORAL: HautKompass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib
Status: COMPLETED
Conditions: Drug-drug Interaction
Interventions: DRUG: tucatinib|DRUG: itraconazole|DRUG: rifampin|DRUG: gemfibrozil|DRUG: repaglinide|DRUG: tolbutamide|DRUG: midazolam|DRUG: digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nodal Status in Adenocarcinoma of the Esophagus an Cardia
Status: COMPLETED
Conditions: Adenocarcinoma of the Esophagus|Adenocarcinoma of the Gastric Cardia
Interventions: PROCEDURE: Subtotal esophagectomy and gastric pull up|PROCEDURE: Subtotal esophagectomy at the azygos vein, total gastrectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Angio-seal VIP Versus Perclose ProGlide for Closure of the Femoral Artery in Peripheral Vascular Disease
Status: UNKNOWN
Conditions: Peripheral Vascular Diseases|Percutaneous Intervention Via Femoral Artery
Interventions: DEVICE: Perclose ProGlide|DEVICE: Angio-seal VIP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Balanced Slat Colloid HES 130/0.42 on Coagulation Profiles in Patients Undergoing Spinal Cord Tumor Surgery
Status: TERMINATED
Conditions: Coagulation
Interventions: OTHER: Valanced salt colloid|OTHER: Valanced salt crystalloid group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dose Escalation Study to Determine the Pharmacokinetics of Atazanavir Administered With RIfampicin to HIV Positive Adults on sEcond-line ART Regimen With Suppressed HIV-1 Viral Load
Status: COMPLETED
Conditions: HIV/AIDS|Tuberculosis
Interventions: DRUG: Dose escalation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-"Omics" Research of Danhong Injection to Treat Acute Ischemic Stroke
Status: COMPLETED
Conditions: Acute Stroke
Interventions: DRUG: Danhong injection|PROCEDURE: Standard medical care|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trametinib in Increasing Tumoral Iodine Incorporation in Patients With Recurrent or Metastatic Thyroid Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Thyroid Gland Carcinoma|Poorly Differentiated Thyroid Gland Carcinoma|Recurrent Thyroid Gland Carcinoma|Refractory Thyroid Gland Carcinoma|Stage IV Thyroid Gland Follicular Carcinoma AJCC v7|Stage IV Thyroid Gland Papillary Carcinoma AJCC v7|Stage IVA Thyroid Gland Follicular Carcinoma AJCC v7|Stage IVA Thyroid Gland Papillary Carcinoma AJCC v7|Stage IVB Thyroid Gland Follicular Carcinoma AJCC v7|Stage IVB Thyroid Gland Papillary Carcinoma AJCC v7|Stage IVC Thyroid Gland Follicular Carcinoma AJCC v7|Stage IVC Thyroid Gland Papillary Carcinoma AJCC v7
Interventions: PROCEDURE: Computed Tomography|OTHER: Iodine I 124|RADIATION: Iodine I-131|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacodynamic Study|PROCEDURE: Positron Emission Tomography|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Dexlansoprazole Capsules From Two Manufacturing Plants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: 30 mg dexlansoprazole capsules manufactured at TOB|DRUG: 30 mg dexlansoprazole capsules manufactured at TPC|DRUG: 60 mg dexlansoprazole capsules manufactured at TOB|DRUG: 60 mg dexlansoprazole capsules manufactured at TPC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Ovarian Needle Puncture for Follicle Activation in IVF Patients With Diminished Ovarian Reserve
Status: UNKNOWN
Conditions: Activation of Primordial Follicles
Interventions: PROCEDURE: Ovarian puncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids
Status: COMPLETED
Conditions: Heavy Menstrual Bleeding|Menorrhagia|Uterine Fibroids
Interventions: DRUG: Levonorgestrel IUS|DRUG: Tranexamic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Novel Target Delineation Scheme in High-grade Glioma Patients: a Randomized Single-blind Clinical Trial
Status: RECRUITING
Conditions: Radiation Toxicity|MRI Simulated Positioning|High Grade Glioma|Progression-free Survival|Overall Survival
Interventions: RADIATION: reduced target volume|RADIATION: EORTC (European organisation for research and treatment of cancer) target volume
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prevention of NCDs Through Screening and Educating Individuals on Health-risk Behaviours in the Community
Status: ACTIVE_NOT_RECRUITING
Conditions: Health-risk Behaviours|Non Communicable Diseases
Interventions: OTHER: Theory of planned behaviour, foot-in-the-door technique, and self-determination theory intervention|OTHER: health-risk behaviors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Folic Acid Therapy for Hyperhomocysteinemia in Patients With End Stage Renal Disease Receiving Hemodialysis
Status: COMPLETED
Conditions: End Stage Renal Disease|Hyperhomocysteinemia
Interventions: DRUG: cyanocobalamin|DRUG: folic acid|DRUG: pyridoxine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Multicenter Prospective Evaluation of the Incidence and Serotyes of Invasive Pneumoccocal Disease (IPD) Among Children Below 5 Years
Status: UNKNOWN
Conditions: Pneumococcal Disease
Interventions: BIOLOGICAL: pneumococcal conjugate vaccine(prevenar)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Study of Amiodarone Given Before Lung Surgery to Prevent Atrial Fibrillation After Lung Resection
Status: TERMINATED
Conditions: Atrial Fibrillation|Lung Cancer
Interventions: DRUG: Amiodarone|OTHER: Control arm, standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Microwave Ablation in BosniakⅠ~ⅡF Cystic Renal Lesions
Status: UNKNOWN
Conditions: Kidney Diseases,Cystic
Interventions: PROCEDURE: microwave ablation|PROCEDURE: laparoscopic decortication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accelerated Fractionation Radiotherapy (AFRT) Versus Concurrent Chemoradiotherapy (Crt) In Locally Advanced Head And Neck Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: HEAD AND NECK CANCER
Interventions: DRUG: CISPLATIN|RADIATION: EXTERNAL BEAM RADIOTHERAPY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Isoquercetin as an Adjunct Therapy in Patients With Kidney Cancer Receiving First-line Sunitinib: a Phase I/II Trial
Status: UNKNOWN
Conditions: Renal Cell Carcinoma|Kidney Cancer
Interventions: DRUG: Sunitinib|DRUG: Isoquercetin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Metformin on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and Progesterone
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Hyperandrogenism
Interventions: DRUG: Metformin|DRUG: Progesterone|DRUG: estrace
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dialysis Performance of the FX CorAL Membrane
Status: ACTIVE_NOT_RECRUITING
Conditions: Hemodialysis Complication|Anticoagulants
Interventions: OTHER: Anticoagulation dosing|OTHER: Blood sampling|OTHER: Duration of the dialysis session|DEVICE: Choice of the hemodialyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Artemether-lumefantrine and Amodiaquine in Healthy Subjects
Status: RECRUITING
Conditions: Pharmacokinetic|Healthy|Drug Combination
Interventions: DRUG: Artemether-lumefantrine|DRUG: Amodiaquine|DRUG: Artemether-lumefantrine|DRUG: Artemether-lumefantrine + Amodiaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization of Adaptive Text Messages for Cancer Survivors (OATS II)
Status: RECRUITING
Conditions: Colon Adenocarcinoma|Colorectal Carcinoma|Rectal Adenocarcinoma
Interventions: BEHAVIORAL: Dietary intervention via Text Messaging|OTHER: Survey Administration|BEHAVIORAL: Nutrition Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase III Study of ASP2151 in Herpes Simplex Patients
Status: COMPLETED
Conditions: Herpes Simplex
Interventions: DRUG: ASP2151|DRUG: ASP2151 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Panitumumab in Combination With FOLFIRI Chemotherapy as Second Line Treatment in Subjects With Metastatic Colorectal Cancer Expressing Wild-type KRAS and Who Had Progressed ≥ 6 Months After the Last Dose of the First Line Chemotherapy
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Panitumumab + FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Satavaptan for the Prevention of Ascites Recurrence in Patients With Ascites Due to Cirrhosis of the Liver
Status: TERMINATED
Conditions: Ascites|Liver Cirrhosis
Interventions: DRUG: Satavaptan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Pediatric Endurance and Limb Strengthening (PEDALS) Program VS Task-Oriented Training (TOT) Improving Gross Motor Function in Children With Cerebral Palsy
Status: NOT_YET_RECRUITING
Conditions: Cerebral Palsy
Interventions: OTHER: Pediatric Endurance and Limb Strengthening (PEDALS) program|OTHER: Task-Oriented Training (TOT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Inspiratory Muscle Training in Patients With Post COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: OTHER: Inspiratory Muscle Training Group|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Rate of Maxillary En-masse Retraction Using 0.018-inch Versus 0.022-inch Slot Brackets in Adults
Status: UNKNOWN
Conditions: Orthodontic Tooth Movement
Interventions: PROCEDURE: Bonding|PROCEDURE: Leveling and alignment|PROCEDURE: Extraction|PROCEDURE: Retraction|PROCEDURE: Digital models|PROCEDURE: measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of a Commercially Available Vaccine Co-administered With GSK HPV Vaccine (580299)
Status: COMPLETED
Conditions: Infections, Papillomavirus|Papillomavirus Vaccines
Interventions: BIOLOGICAL: Subjects received 3 doses of GSK Biologicals' HPV vaccine (580299) (Cervarix™)|BIOLOGICAL: Engerix™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Depakote ER Therapy for Mania Comorbid With Substance Abuse
Status: COMPLETED
Conditions: Bipolar Disorder|Mania|Substance Abuse|Substance Dependence
Interventions: DRUG: Divalproex ER
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Whole-Heart Myocardial Blood Flow Quantification Using MRI
Status: RECRUITING
Conditions: Coronary Artery Disease|Coronary Microvascular Disease
Interventions: DEVICE: Myocardial Perfusion Cardiac MRI.|DRUG: Contrast|DRUG: Pharmacologic Stress Agent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reducing HIV Risk Among Mexican Youth
Status: COMPLETED
Conditions: HIV Infections|AIDS|Sexually Transmitted Diseases
Interventions: BEHAVIORAL: Adolescent Safer Sex Intervention|BEHAVIORAL: Parent Safer Sex Communication Intervention|OTHER: Adolescent Health Promotion Control Condition|OTHER: Parent Health Promotion Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prevention of Lymphorrhea by Lanreotide in Axillary Dissection for Breast Cancer
Status: COMPLETED
Conditions: Lymphocele
Interventions: DRUG: Lanreotide LP 90|DRUG: Placebo lanreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety of Long Term Treatment With Teriflunomide 14 mg Once Daily in Patients With a First Clinical Episode Suggestive of Multiple Sclerosis in a Long-term Extension Period
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Teriflunomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clonidine in Attention Deficit Hyperactivity Disorder (ADHD) in Children
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: clonidine|DRUG: methylphenidate|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Phase II Clinical Trial of Sulforaphane in Bladder Cancer Chemoprevention
Status: WITHDRAWN
Conditions: Bladder Cancer|Bladder Tumor|Urothelial Carcinoma
Interventions: DRUG: Sulforaphane Administration|OTHER: Placebo Administration|PROCEDURE: Standard of Care Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pimavanserin for the Treatment of Irritability Associated With Autism Spectrum Disorder
Status: ACTIVE_NOT_RECRUITING
Conditions: Irritability Associated With Autism Spectrum Disorder
Interventions: DRUG: Pimavanserin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Far Infrared Irradiation for Management and Treating of Parkinson's Disease (PD)
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: RADIATION: Far Infrared Radiation (5μm to 20μm wavelength)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Target Delineation and Radiation Doses Chemoradiotherapy for Patients With Locoregionally Advanced Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma
Interventions: RADIATION: Reduced Target Delineation and Radiation Doses
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide With or Without Rituximab in Treating Patients With Progressive or Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Prolymphocytic Leukemia, or Non-Hodgkin Lymphoma Previously Treated With Donor Stem Cell Transplant
Status: TERMINATED
Conditions: Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Prolymphocytic Leukemia|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|T-cell Large Granular Lymphocyte Leukemia|Testicular Lymphoma|Waldenström Macroglobulinemia
Interventions: DRUG: lenalidomide|BIOLOGICAL: rituximab|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Steel Wire to a Flat, Braided Suture to Close the Breastbone
Status: COMPLETED
Conditions: Sternotomy
Interventions: DEVICE: Stainless Steel Wire Cerclage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE