pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Lapatinib in Breast Cancer Patients With HER-2 Non-amplified Primary Tumors and HER-2 Positive or EGFR Positive Circulating Tumor Cells
Status: TERMINATED
Conditions: Neoplasms, Breast
Interventions: DRUG: LAPATINIB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Establishing a ctDNA Biomarker to Improve Organ Preserving Strategies in Patients With Rectal Cancer
Status: RECRUITING
Conditions: Rectal Adenocarcinoma|Stage II Rectal Cancer AJCC v8|Stage IIA Rectal Cancer AJCC v8|Stage IIB Rectal Cancer AJCC v8|Stage IIC Rectal Cancer AJCC v8|Stage III Rectal Cancer AJCC v8|Stage IIIA Rectal Cancer AJCC v8|Stage IIIB Rectal Cancer AJCC v8|Stage IIIC Rectal Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|OTHER: Electronic Health Record Review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Efficacy and Safety of SPH4336 Monotherapy or in Combination With Cadonilimab in Patients With Advanced Solid Tumors.
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: SPH4336|DRUG: Cadonilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Orthosis of Acute Traumatic Rib Fractures Via RibFx Belt for Pain Alleviation and Improved Pulmonary Function
Status: TERMINATED
Conditions: Rib Fracture|Rib Fracture Multiple|Trauma|Trauma Chest|Trauma Injury|Trauma, Multiple
Interventions: DEVICE: RibFx Orthosis Belt
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LIFT: Life Improvement Trial
Status: NOT_YET_RECRUITING
Conditions: ME/CFS
Interventions: DRUG: Pyridostigmine|DRUG: Low-Dose Naltrexone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enteral Nutrition Tolerance And REspiratory Support (ENTARES)
Status: COMPLETED
Conditions: Very Low Birth Weight Infant|Respiratory Distress Syndrome in Premature Infant|Enteral Feeding Intolerance
Interventions: DEVICE: HHHFNC|DEVICE: NCPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CC-122 to Evaluate the Safety, Tolerability, and Effectiveness for Patients With Advanced Solid Tumors, Non-Hodgkin's Lymphoma, or Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma|Lymphoma, Large B-Cell, Diffuse|Pleiotropic Pathway Modifier|Glioblastoma|Lymphoma|Primary Central Nervous System Lymphoma
Interventions: DRUG: CC-122|DRUG: CC-122|DRUG: CC-122|DRUG: CC-122
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Post Sexual Assault Stress
Status: COMPLETED
Conditions: Drug Use|Drug Abuse|Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: PPRS|BEHAVIORAL: PIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence Study of Levetiracetam Tablet and Intravenous Infusion in Healthy Japanese Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Levetiracetam|DRUG: Levetiracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: CogT BEEM Study (a tDCS Study)
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Neuropsychiatric Syndrome
Interventions: DEVICE: tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacokinetic and Pharmacodynamic Drug-Drug Interaction of Evogliptin and Empagliflozin or Dapagliflozin in Healthy Male Adults
Status: COMPLETED
Conditions: Type2 Diabetes
Interventions: DRUG: Evogliptin→Evogliptin+Empagliflozin→Empagliflozin|DRUG: Empagliflozin→Evogliptin→Evogliptin+Empagliflozin|DRUG: Evogliptin→Evogliptin+Dapagliflozin→Dapagliflozin|DRUG: Dapagliflozin→Evogliptin→Evogliptin+Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Does Magnetic Resonance Imaging (MRI) Improve Interventional Outcomes for Lumbosacral Radiculopathy?
Status: COMPLETED
Conditions: Lumbosacral Radiculopathy
Interventions: PROCEDURE: Epidural steroid injection|PROCEDURE: Epidural steroid injection|PROCEDURE: Magnetic Resonance Imaging (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Safety of TTAC-0001(Tanibirumab) in Recurrent Glioblastoma
Status: COMPLETED
Conditions: Recurrent Glioblastoma
Interventions: DRUG: TTAC-0001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Ophthalmic Antiseptic Preparations
Status: COMPLETED
Conditions: Antiseptics|Microbiota|Conjunctiva
Interventions: DEVICE: Povidone-Iodine 0.66%|DEVICE: Chlorhexidine 0.02%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Feasibility Study of Peripheral Venous Cannulation Pain in Predicting Acute Pain After Total Knee Arthroplasty
Status: NOT_YET_RECRUITING
Conditions: Venous Cannulation Pain|Total Knee Arthroplasty|Movement-evoked Pain|Acute Pain
Interventions: OTHER
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Adults
Status: ENROLLING_BY_INVITATION
Conditions: Frail Elderly Syndrome
Interventions: DIETARY_SUPPLEMENT: Fisetin|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Management for HNSCC Based on Pathological Response of Induction Chemotherapy and Immunotherapy
Status: RECRUITING
Conditions: Head and Neck Cancer
Interventions: COMBINATION_PRODUCT: anti-PD-1 or PD-L1 antibody|RADIATION: postoperative radiaotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transdermal Buprenorphine Patch for Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Laparoscopic Cholecystectomy
Interventions: DRUG: buprenorphine patch group|DRUG: placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Study to Evaluate the Efficacy of a Range of Dental/Denture Products for Improved Oral Health in Partial Denture Wearers
Status: COMPLETED
Conditions: Gingivitis
Interventions: OTHER: Experimental Dentifrice: Stannous Fluoride|DEVICE: COREGA Denture Foaming Cleanser|OTHER: Mouth rinse: Sodium Fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Single Dose Crossover Pharmacokinetics Study Of JDP-205 Injection, 10 mg, In Healthy Male And Female Volunteers
Status: COMPLETED
Conditions: Acute Urticaria
Interventions: OTHER: Deep muscle injection|OTHER: Sub-Q Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Plus Cisplatin Versus Gemcitabine Plus Paclitaxel in Triple Negative Breast Cancer (TNBC)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Gemcitabine,cisplatin|DRUG: Gemcitabine, Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of 18F-DCFPyL PET/CT in the Evaluation of Men With an Elevated PSA Following Radical Prostatectomy
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate
Interventions: DRUG: 18F-DCFPyL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of FURESTEM-AD Inj. for Moderate to Severe Atopic Dermatitis (AD)
Status: UNKNOWN
Conditions: Dermatitis, Atopic
Interventions: BIOLOGICAL: FURESTEM-AD® inj. 5.0 X 10^7 cells/1.5 mL|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability (rBA) of Evobrutinib Intended Commercial and Clinical Tablets, and Effect of Food on Intended Commercial Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Evobrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Proton Pump Inhibitor and H2 Receptor Blocker on Prevention of Bleeding From Iatrogenic Ulcer After Endoscopic Submucosal Dissection for Gastric Neoplasms: A Prospective Randomized Controlled Trial
Status: UNKNOWN
Conditions: Delayed Bleeding
Interventions: DRUG: high dose proton pump inhibitor|DRUG: H2RB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana
Status: COMPLETED
Conditions: Onchocerciasis
Interventions: DRUG: IVM plus ALB|DRUG: IVM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Compare Efficacy and Safety of CT-P47 and RoActemra in Patients With Rheumatoid Arthritis
Status: NOT_YET_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: CT-P47|BIOLOGICAL: EU-approved RoActemra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Different Vibration Exercises on COPD Patients
Status: NOT_YET_RECRUITING
Conditions: COPD|COPD Chronic Obstructive Pulmonary Disease|Vibration Therapy
Interventions: DEVICE: Whole-body Vibration Therapy|DEVICE: Local Vibration Therapy|DEVICE: Sham Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiotherapy and Therapeutic Education on Patients With Pain Catastrophism Scheduled for a Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteo Arthritis Knee|Knee Arthroplasty|Catastrophizing|Pain
Interventions: OTHER: Pain Neuroscience Education|OTHER: Multimodal Physiotherapy|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Using Artificial Intelligence to Optimize Delivery of Weight Loss Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Weight Loss
Interventions: BEHAVIORAL: Standard Behavioral Weight Loss Treatment|BEHAVIORAL: AI-optimized Behavioral Weight Loss Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tibial Nerve and Extracorporeal Magnetic Stimulation for Overactive Bladder
Status: RECRUITING
Conditions: Idiopathic Overactive Bladder|Bladder Training|Transcutaneous Tibial Nerve Stimulation|Magnetic Stimulation
Interventions: DEVICE: Magnetic stimulation -Armchair type MS • NovaMag NT-60|DEVICE: Electrical Stimulation- TTNS|BEHAVIORAL: Bladder Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Performance Evaluation of BCG Vaccination in Healthcare Personnel to Reduce the Severity of COVID-19 Infection.
Status: WITHDRAWN
Conditions: COVID-19
Interventions: BIOLOGICAL: vaccine BCG|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Of Daratumumab, Low-Dose Oral Dexamethasone and Cyclophosphamide With Or Without Pomalidomide
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: DCdP|BIOLOGICAL: DCd+P
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Correlation of NIRS, ABI, Exercise, baPWV and Albuminuria With Peripheral Artery Occlusion Disease (PAD) and Other Atherosclerosis Outcomes
Status: UNKNOWN
Conditions: Diabetes|Peripheral Arterial Occlusive Disease
Interventions: DEVICE: oscillometric (Omron Colin co)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transnasal Humidified Rapid Insufflation Ventilatory Exchange in Morbidly Obese
Status: COMPLETED
Conditions: Anesthesia Intubation Complication|Anesthesia
Interventions: PROCEDURE: low flow passive oxygenation|PROCEDURE: high flow passive oxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety and Pharmacokinetics of MOXR0916 in Participants With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: MOXR0916
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laminectomy Alone Versus Laminectomy and Fusion for Traumatic Cervical Spinal Cord Injury Without Instability
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Spinal Cord Injury
Interventions: PROCEDURE: Laminectomy alone versus laminectomy and fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Neratinib In Combination With Vinorelbine In Subjects With Advanced Or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Advanced Malignant Solid Tumors
Interventions: DRUG: Neratinib|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantitive And Qualitive Assessment Of The Oxygen Delivery And EtCO2 Sampling With The Smart Bite Block Mark III During An Upper Endoscopic Procedure Under Sedation
Status: UNKNOWN
Conditions: Ventilatory Status of Deeply Sedated ERCP Patients
Interventions: DEVICE: monitored using currently marketed smart biteblock o2|DEVICE: monitored using investigational smart biteblock
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Molecular Profiling of Exosomes in Tumor-draining Vein of Early-staged Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer|Exosomes|Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: Blood samples at 2 sites: peripheral vein and tumor-draining vein
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study Evaluating the Efficacy, Safety, and Pharmacokinetics of Glofitamab in Combination With Rituximab Plus Ifosfamide, Carboplatin Etoposide Phosphate in Participants With Relapsed/Refractory Transplant or CAR-T Therapy Eligible Diffuse B-Cell Lymphoma
Status: RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma (DLBCL)
Interventions: DRUG: Glofitamab|DRUG: Obinutuzumab|DRUG: Tocilizumab|DRUG: Rituximab|DRUG: Ifosfamide|DRUG: Carboplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S9921, Hormone Therapy With or Without Mitoxantrone and Prednisone in Patients Who Have Undergone Radical Prostatectomy for Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: bicalutamide|DRUG: goserelin|DRUG: mitoxantrone hydrochloride|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Redirected High Affinity Gag-Specific Autologous T Cells for HIV Gene Therapy
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: WT-gag-TCR modified T cells|BIOLOGICAL: α/6-gag-TCR modified T cells|OTHER: STI or Drug Holiday
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Application of Nasal Cannula With Oxygen Versus Air During Eye Surgery Under Local Anaesthetic
Status: COMPLETED
Conditions: Hypoxia|Hypercapnia
Interventions: DRUG: oxygen|DRUG: oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: iCare4Depression: Effectiveness of a Blended Cognitive-Behavioral Therapy in Routine Practice
Status: UNKNOWN
Conditions: Major Depression
Interventions: BEHAVIORAL: blended Cognitive-behavioral Therapy|OTHER: Treatment-As-Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dacarbazine and/or Cisplatin Compared With Complete Metastasectomy in Treating Patients With Stage IV Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: DRUG: cisplatin|DRUG: dacarbazine|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Crossover Trial of AD182 and AD504 in Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: AD182|DRUG: AD504|DRUG: Placebo|DIAGNOSTIC_TEST: Polysomnography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preclinical Medical Student Echocardiography Training American Society of Echocardiography Curriculum
Status: COMPLETED
Conditions: Echocardiography|Medical Student|Transthoracic Echocardiography|Education
Interventions: OTHER: Basic cardiac ultrasound training with Butterfly iQ handheld ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of Dendritic Cell Therapy for Myeloid Leukemia and Myeloma
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia|Chronic Myeloid Leukemia|Multiple Myeloma
Interventions: BIOLOGICAL: dendritic cell vaccination (active specific immunotherapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Treating Late-Life Generalized Anxiety Disorder (GAD) in Primary Care
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: BEHAVIORAL: Cognitive Behavior Therapy|BEHAVIORAL: Telephone check-in
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First Time in Human Study Using GSK2330672
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: placebo|DRUG: 0.1 mg GSK2330672|DRUG: 0.3 mg GSK2330672|DRUG: 1 mg GSK2330672|DRUG: 3 mg GSK2330672|DRUG: 10 mg GSK2330672|DRUG: 30 mg GSK2330672|DRUG: 60 mg GSK2330672
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase III Clinical Worsening Study of UT-15C in Subjects With PAH Receiving Background Oral Monotherapy
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Treprostinil Diolamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Alberta Neonatal Abstinence Syndrome Mother-Baby Care ImprovEmeNT Program
Status: RECRUITING
Conditions: Neonatal Abstinence Syndrome
Interventions: BEHAVIORAL: Rooming-in care|BEHAVIORAL: Baseline standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cross-over Study to Evaluate the Effect on Trough Forced Expiratory Volume in One Second (FEV1) After 4 Weeks Treatment With CHF 5188 pMDI qd in Adult Patients With Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: CHF 5188 pMDI|DRUG: Budesonide extrafine pMDI|DRUG: Seretide(r) Evohaler(r)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Accessible Low-cost Plant Treatment for Cutaneous Ulcers
Status: COMPLETED
Conditions: Yaws; Cutaneous|Cutaneous Ulcer|Yaws
Interventions: BIOLOGICAL: Topical antiseptic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of AZD1775 on the PK Substrates for CYP3A, CYP2C19, CYP1A2 and on QT Interval in Patients With Advanced Cancer
Status: COMPLETED
Conditions: Solid Tumours
Interventions: DRUG: CYP1A2 (caffeine)|DRUG: CYP2C19 (omeprazole)|DRUG: CYP3A (midazolam)|DRUG: Kytril (granisetron)|DRUG: Wee-1 kinase inhibitor AZD1775
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Delirium Prevention With Ketamine in Ear, Nose, and Throat (ENT) Patients
Status: TERMINATED
Conditions: Otolaryngeal Cancer
Interventions: DRUG: Ketamine|DRUG: Placebo|DEVICE: Electroencephalogram (EEG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Different Diets on Arterial Stiffness in Obese Patients on Semaglutide
Status: RECRUITING
Conditions: Obesity|Weight Loss
Interventions: OTHER: Dietary Intervention Med Diet|OTHER: Dietary Intervention HP/LC Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Congenital Muscular Dystrophy Ascending Multiple Dose Cohort Study Analyzing Pharmacokinetics at Three Dose Levels In Children and Adolescents With Assessment of Safety and Tolerability of Omigapil (CALLISTO)
Status: COMPLETED
Conditions: Congenital Muscular Dystrophy
Interventions: DRUG: Omigapil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention and Treatment of Patient Before, During, and After Covid-19 Infection
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: AntiCov-220 (1)|DRUG: AntiCov-220 (2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cotransplantation of Islet and Mesenchymal Stem Cell in Type 1 Diabetic Patients
Status: UNKNOWN
Conditions: Type 1 Diabetes Mellitus
Interventions: BIOLOGICAL: cotransplantation of islet and mesenchymal stem cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a Respiratory Syncytial Virus Candidate Formulation in Adults Aged 60 Years and Older
Status: RECRUITING
Conditions: Respiratory Syncytial Virus Infection|Healthy Volunteers
Interventions: BIOLOGICAL: RSV vaccine candidate|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Supporting All Families of Premature Infants at Prentice Women's Hospital From Admission Through Discharge
Status: ACTIVE_NOT_RECRUITING
Conditions: Premature Infant|Premature Birth|NICU
Interventions: OTHER: Group 1: Standard of Care|OTHER: Group 2: NICU2HOME app|OTHER: Group 3: SMART NICU2HOME app
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Usability and Tolerability of the Norditropin NordiFlex® Injection Device in Children Never Previously Treated With Growth Hormone
Status: COMPLETED
Conditions: Growth Hormone Disorder|Growth Hormone Deficiency in Children|Genetic Disorder|Turner Syndrome|Foetal Growth Problem|Small for Gestational Age|Chronic Kidney Disease|Chronic Renal Insufficiency|Delivery Systems
Interventions: DRUG: Norditropin NordiFlex®
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transfusion of Pathogen Reduced Cryoprecipitated Fibrinogen to Expedite Product Availability in Perioperative Bleeding
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypofibrinogenemia|Bleeding
Interventions: BIOLOGICAL: Traditional Cryoprecipitate|BIOLOGICAL: Pathogen-Reduced Cryoprecipitate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Association of Non-alcoholic Fatty Liver Disease and Diabetes Mellitus
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease (NAFLD)
Interventions: DEVICE: Controlled Attenuation Parameter (CAP), Echosens, Paris, France|DEVICE: FibroScan, Echosens, Paris, France
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Application of Impedance Threshold Device Technologies to Treat and Prevent Hypotension During Dialysis
Status: TERMINATED
Conditions: Intradialytic Hypotension|End Stage Renal Disease|Low Blood Pressure
Interventions: DEVICE: ITD|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Homogenized and Unhomogenized Milk on Postprandial Metabolism in Healthy Overweight Men
Status: COMPLETED
Conditions: Hyperlipidemias|Inflammation|Atherosclerosis
Interventions: DIETARY_SUPPLEMENT: Homogenized milk|DIETARY_SUPPLEMENT: Unhomogenized milk|DIETARY_SUPPLEMENT: Skimmed Milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Different Inhalation Oxygen Concentrations on Postoperative Atelectasis
Status: COMPLETED
Conditions: Atelectasis
Interventions: DRUG: 30% Oxygen|DRUG: 60% Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gait Training Through a Novel Over-ground Wearable Robotic System in People With Pyramidal Hemisyndromes
Status: ACTIVE_NOT_RECRUITING
Conditions: Stroke|Brain Injuries, Traumatic|Brain Tumor Benign
Interventions: DEVICE: Indego Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study of Perioperative Intravenous Infusion of Lidocaine on Postoperative Analgesia in Patients Undergoing Single-port Thoracoscopic
Status: UNKNOWN
Conditions: Surgery
Interventions: DRUG: Lidocaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TEST-ON - Does iStim Reduce Urinary Urgency?
Status: UNKNOWN
Conditions: Overactive Bladder|Urgency-frequency Syndrome|Urinary Frequency More Than Once at Night
Interventions: DEVICE: iStim TENS unit and Transvaginal Probe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cefiderocol and Ampicillin-sulbactam vs. Colistin +/- Meropenem for Carbapenem Resistant A. Baumannii
Status: NOT_YET_RECRUITING
Conditions: Carbapenem Resistant Bacterial Infection|Acinetobacter Bacteremia|Acinetobacter Pneumonia
Interventions: DRUG: Cefiderocol|DRUG: Ampicillin-sulbactam|DRUG: Colistin|DRUG: Meropenem
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-dose Phase 1 Study of DBPR108 in Healthy Male Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: DBPR108|DRUG: matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Treatment of Cutaneous Leishmaniasis With WR 279,396: A Phase 2 Study in the Old World
Status: COMPLETED
Conditions: Cutaneous Leishmaniasis
Interventions: DRUG: WR 279,396|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304)
Status: ACTIVE_NOT_RECRUITING
Conditions: Bladder Cancer
Interventions: BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Enfortumab vedotin (EV)|PROCEDURE: RC + PLND|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Cabozantinib for Recurrent or Progressive Central Nervous System Tumors in Children
Status: TERMINATED
Conditions: Glioblastoma Multiforme|Anaplastic Astrocytoma|Malignant Brain Tumor|High Grade Glioma
Interventions: DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CVAD-Associated Skin Impairment in Allogeneic Stem Cell Transplant Recipients: Dressing vs No-Dressing
Status: COMPLETED
Conditions: Central Line Complication
Interventions: OTHER: Dressing|OTHER: No-Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Basal Insulins - Pharmacodynamics
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: Insulin detemir|DRUG: Insulin glargine|DRUG: Insulatard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gastrointestinal Tolerability of a Partially Hydrolyzed Ready-to-feed Infant Formula in Healthy Newborns
Status: COMPLETED
Conditions: Infant Nutritional Physiological Phenomena|Infant Formula
Interventions: OTHER: NAN Supreme HypoAllergenic Starter Infant Formula in ready-to-feed format
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: HFP (High-Fiber Supplement) in MS (Multiple Sclerosis)
Status: ENROLLING_BY_INVITATION
Conditions: Multiple Sclerosis
Interventions: DRUG: NBT-NM108 (60 g/day)|OTHER: NBT-NM108 (0 g/day)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of NM26-2198 in Healthy Subjects and in Patients With Moderate-to-severe Atopic Dermatitis (AD)
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: NM26-2198|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation in Childhood Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DIETARY_SUPPLEMENT: cholecalciferol (vitamin D)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Vitamin E Supplementation on Free Radicals and Fat Level of Obese Adolescence in Jakarta, Indonesia
Status: COMPLETED
Conditions: Obesity, Adolescent|Oxidative Stress
Interventions: DRUG: Vitamin E 400 UNT|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Mobile App to Assist in Pediatric Triage
Status: NOT_YET_RECRUITING
Conditions: Pediatric Triage in a Pediatric Emergency Department
Interventions: OTHER: PEWS calculation by parents using AI-based smartphone app|OTHER: PEWS calculation by nurse using conventional procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Clinical Efficacy and Safety of Tamsulosin Alone or in Combination With Solifenacin for the Treatment in Men With Lower Urinary Tract Symptoms Including Overactive Bladder Symptoms
Status: COMPLETED
Conditions: Lower Urinary Tract Symptoms|Overactive Bladder|Benign Prostatic Hyperplasia (BPH)
Interventions: DRUG: Tamsulosin|DRUG: Solifenacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neural Circuit Effects of Ketamine in Depression
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Ranibizumab 0.5 mg Administered as Two Alternative Dosing Regimens in Chinese Patients With nAMD (Age Related Macular Degeneration)
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing GSK1349572 50mg Once Daily to Raltegravir 400mg Twice Daily
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus I
Interventions: DRUG: GSK1349572 (dolutegravir)|DRUG: raltegravir|OTHER: GSK1349572 Placebo|OTHER: ABC/3TC|OTHER: TDF/FTC|OTHER: raltegravir Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Organoid-based Functional Precision Therapy for Advanced Breast Cancer
Status: RECRUITING
Conditions: HER2-negative Breast Cancer|Advanced Breast Cancer
Interventions: DRUG: Organoid-guided treatment|DRUG: Taxane|DRUG: Capecitabine|DRUG: Gemcitabine|DRUG: Vinorelbine|DRUG: Eribulin|DRUG: Anthracycline|DRUG: Carboplatin|DRUG: Utidelone|DRUG: Trastuzumab deruxtecan|DRUG: Sacituzumab govitecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lutein and Alzheimer's Disease Study
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DIETARY_SUPPLEMENT: lutein/zeaxanthin|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short-course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for Locally Advanced Rectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Rectal Neoplasms Malignant|Radiotherapy
Interventions: DRUG: Sintilimab|RADIATION: Short-course radiotherapy|COMBINATION_PRODUCT: CAPOX/mFOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization and Clinical Trial of a Variable Friction Shoe
Status: RECRUITING
Conditions: Stroke
Interventions: DEVICE: Variable Friction Shoe Training|DEVICE: Ankle Foot Orthosis (AFO) Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Molecular Imaging of Fulvestrant Effects on Availability of ER Binding Sites
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: OTHER: Diagnostic intervention: Positron Emission Tomography with 16-alpha-[18-fluoro]-17betaestradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Beta-Hydroxybutyrate Feasibility Treating IBD
Status: RECRUITING
Conditions: Crohn's Disease|Inflammatory Bowel Diseases
Interventions: BIOLOGICAL: Feasibility of beta-hydroxybutyrate supplementation to reduce inflammation in patients with Crohn's
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Granisetron to Prevent Nausea and Vomiting After Chemotherapy in Patients With Malignant Disease
Status: UNKNOWN
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: granisetron hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Planter Vibration and Otago Exercise in Old Hemiplegic Patients
Status: COMPLETED
Conditions: Balance Disorders
Interventions: DEVICE: Local Plantar vibrator|OTHER: Otago exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Combination Biotherapy With Pembrolizumab and High Dose IFN-alfa2b
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Pembrolizumab and high dose interferon alfa-2b (HDI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug-durg Interaction of ZSP1273 With Digoxin, Rosuvastatin,Itraconazole and Probenecid
Status: COMPLETED
Conditions: Drug Drug Interaction
Interventions: DRUG: Digoxin|DRUG: Rosuvastatin|DRUG: ZSP1273|DRUG: Itraconazole|DRUG: Probenecid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract
Status: RECRUITING
Conditions: Essential Tremor
Interventions: DEVICE: Deep Brain Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: COVID-19 Vaccination Hesitancy in Adults With Sickle Cell Disease
Status: RECRUITING
Conditions: Sickle Cell Disease|COVID-19 Vaccine|Vaccine Hesitancy
Interventions: BEHAVIORAL: SCD-specific COVID-19 vaccination information (SCVI) video
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of PK and BE of VM-1500FDC (Fixed-dose Combination) and Elpida® With Truvada® сo-administrated 1 Daily Fasting in Healthy Subjects
Status: COMPLETED
Conditions: HIV-1-infection
Interventions: DRUG: VM-1500FDC|DRUG: Elpida®|DRUG: Truvada®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Procalcitonin and Antimicrobial Utilization in Critically Ill Cancer Patients With Sepsis
Status: UNKNOWN
Conditions: Sepsis|Septic Shock|Neoplasm|Critical Illness
Interventions: DIAGNOSTIC_TEST: Procalcitonin Levels|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: HD-tDCS Combined With Circadian Rhythm Reconstruction and Micro Expression Changes on Consciousness Recovery in Patients With Chronic Disturbance of Consciousness
Status: RECRUITING
Conditions: Disorder of Consciousness
Interventions: DRUG: Melatonin|OTHER: Placebo|OTHER: HD-tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Immunogenicity of TBC-M4, a MVA HIV Vaccine Alone or in a Prime-Boost Regimen With ADVAX DNA HIV Vaccine
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: ADVAX|BIOLOGICAL: TBC-M4|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Topical Imiquimod for Bowen's Disease of the Head and Neck
Status: UNKNOWN
Conditions: Bowens Disease
Interventions: DRUG: Imiquimod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of H7-Coil DTMS Compared to H1-Coil DTMS in Subjects With Major Depression Disorder (MDD)
Status: UNKNOWN
Conditions: Major Depressive Disorder (MDD)
Interventions: DEVICE: H7-Coil|DEVICE: H1-Coil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Adding Allogenic Stem Cells After Traditional Treatment of Osteochondral Lesions of the Talus
Status: RECRUITING
Conditions: Osteochondral Fracture of Talus
Interventions: BIOLOGICAL: Allogenic stromal mesenchymal cells derived from the umbilical cord|PROCEDURE: Debridement and microfracture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MC5-A Scrambler Therapy in Reducing Peripheral Neuropathy Caused by Chemotherapy
Status: COMPLETED
Conditions: Pain|Peripheral Neuropathy
Interventions: OTHER: scrambler therapy|PROCEDURE: sham intervention|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Virtual Reality Intervention for the Reduction of Behavioral and Psychological Symptoms of Dementia
Status: RECRUITING
Conditions: Dementia|Alzheimer's Disease|Neurocognitive Disorders
Interventions: DEVICE: LUMEEN Virtual Reality sessions|BEHAVIORAL: Control/non-digital stimulation sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Experimental Medicine Studies of the Brain in Patients With Rheumatoid Arthritis REALISE
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Adalimumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: DiamondTemp™ System for the Treatment of Persistent Atrial Fibrillation
Status: ACTIVE_NOT_RECRUITING
Conditions: Persistent Atrial Fibrillation|Atrial Fibrillation
Interventions: DEVICE: Radiofrequency Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Green Tea Supplementation, Fat Oxidation and Body Composition in Overweight Individuals
Status: COMPLETED
Conditions: Overweight and Obesity|Fat Burn
Interventions: DIETARY_SUPPLEMENT: Placebo control|DIETARY_SUPPLEMENT: GTE 1|DIETARY_SUPPLEMENT: GTE 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of PACAP27 on the Extra- and Intracerebral Arteries Assessed by Magnetic Resonance Angiography (MRA) on Healthy Volunteers
Status: COMPLETED
Conditions: Headache, Migraine
Interventions: OTHER: PACAP27|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Epidemiology Study of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)
Status: COMPLETED
Conditions: Anterior Ischemic Optic Neuropathy|Ischemic Optic Neuropathy
Interventions: OTHER: No intervention given in this observational study|OTHER: No intervention given in this observational study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lipofilling: Optimal Harvesting Techniques for Breast Reconstruction After Mastectomy in Plastic Aesthetic and Reconstructive Surgery
Status: COMPLETED
Conditions: The Impact of Adipose Tissue Quality on Fat Graft Retention
Interventions: PROCEDURE: fat grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Dark Chocolate (70% Cacao) on EEG Brain Waves in Vigorously Active Individuals
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: dark chocolate|OTHER: non dark chocolate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER