pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Prospective, Randomized Study Evaluating the Effect of Biliary Stenting on EAU-FNA in Patients With Suspected Malignant Biliary Obstruction
Status: TERMINATED
Conditions: Jaundice
Interventions: PROCEDURE: EUS-FNA first, followed by CRCP with bilinary stenting|PROCEDURE: ERCP with stent placement, followed by EUS-FNA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy Study of Oxazolidinones to Treat Uncomplicated Skin Infections
Status: COMPLETED
Conditions: Infectious Skin Diseases|Bacterial Skin Diseases|Staphylococcal Skin Infections|Streptococcal Infections|Abscess
Interventions: DRUG: Radezolid|DRUG: Radezolid|DRUG: Linezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Safety of Combining Anti-malarial With Deworming Drugs in African Children
Status: UNKNOWN
Conditions: Malaria|Soil Transmitted Helminths|Schistosomiasis|Integrated Control|Seasonal Malaria Chemoprevention|Mass Drug Administration With Anthelminthic Drugs
Interventions: DRUG: Albendazole|DRUG: Praziquantel|DRUG: Amodiaquine|DRUG: Sulfadoxine pyrimethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of an Artificial Human Skin Medicine for Patients With Basal Cell Carcinoma Undergoing Reconstructive Surgery
Status: RECRUITING
Conditions: Basal Cell Carcinoma
Interventions: BIOLOGICAL: PHITAH|BIOLOGICAL: PHIT|BIOLOGICAL: Skin Autograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Applying Modified NUTRIC Scoring System to Evaluate the Nutrition Risk and Giving Different Types of Nutritional Support on Clinical Outcomes in Critically Ill Patients
Status: UNKNOWN
Conditions: Critical Illness
Interventions: DIETARY_SUPPLEMENT: Trophic feeding|DIETARY_SUPPLEMENT: volume-based feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Zoledronic Acid in Patients With Bone Metastases of Any Solid Tumors or Multiple Myeloma
Status: COMPLETED
Conditions: Treatment of Bone Metastases
Interventions: DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Intranasal Esketamine in Treatment-resistant Depression
Status: COMPLETED
Conditions: Treatment Resistant Depressive Disorder
Interventions: DRUG: Esketamine 14 mg|DRUG: Esketamine 28 mg|DRUG: Esketamine 56 mg|DRUG: Esketamine 84 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Retinal Vein Occlusion and Obstructive Sleep Apnea: A Case Control Study
Status: WITHDRAWN
Conditions: Retinal Vein Occlusion|Obstructive Sleep Apnea
Interventions: OTHER: Sleeping Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immunonutrition and Psychosocial Factors in the Recovery of Patients After Gastrectomy: a Multidimensional Analysis
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer|Salutogenesis|Sense of Coherence
Interventions: BEHAVIORAL: Application of questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A First Time in Human Study of PIN201104 in Healthy Volunteers and Patients With Asthma
Status: COMPLETED
Conditions: Healthy Volunteers|Asthma
Interventions: DRUG: PIN201104|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single-Arm, Prospective Study of TBI+BUMEL as Conditioning for SCT2 in Patients With Malignant Hematologic Diseases
Status: RECRUITING
Conditions: Malignant Hematological Diseases
Interventions: PROCEDURE: Second Stem Cell Transplantation (SCT2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of FF-10501-01 in Patients With Relapsed or Refractory Hematological Malignancies
Status: COMPLETED
Conditions: AML|CMML|MDS
Interventions: DRUG: FF-10501-01
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between the 19 and 22 Gauge Needles for Core Tissue Procurement During EUS-guided Procedures
Status: WITHDRAWN
Conditions: Pancreatic Cancer
Interventions: PROCEDURE: 19 gauge|PROCEDURE: 22 gauge
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Differential Diagnosis of Sjögren's Versus Non-Sjögren's Dry Eye
Status: COMPLETED
Conditions: Keratoconjunctivitis Sicca|Dry Eye Syndromes|Ocular Surface Disease|Sjogren's Syndrome
Interventions: DIAGNOSTIC_TEST: Questionnaires|DIAGNOSTIC_TEST: Tear fluid sampling|DIAGNOSTIC_TEST: Impression Cytology
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Role of the Robotic Platform in Inguinal Hernia Repair Surgery
Status: COMPLETED
Conditions: Hernia, Inguinal
Interventions: OTHER: Laparoscopic Inguinal Hernia Repair|OTHER: Robotic Inguinal Hernia Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and TAK-659 as Front-Line Treatment in Treating Patients With High-Risk Diffuse Large B Cell Lymphoma
Status: UNKNOWN
Conditions: Diffuse Large B-Cell Lymphoma|Diffuse Large B-Cell Lymphoma Activated B-Cell Type|Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type|Diffuse Large B-Cell Lymphoma, Not Otherwise Specified|High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements|High Grade B-Cell Lymphoma, Not Otherwise Specified|T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Doxorubicin Hydrochloride|DRUG: Prednisone|BIOLOGICAL: Rituximab|DRUG: Spleen Tyrosine Kinase Inhibitor TAK-659|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of NAC in Decreasing the Incidence of Linezolid-induced Thrombocytopenia in Critically Ill Patients
Status: RECRUITING
Conditions: Linezolid Induced Thrombocytopenia
Interventions: DRUG: N acetyl cysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intravenous Mepolizumab In Subjects With Hypereosinophilic Syndromes (HES)
Status: COMPLETED
Conditions: Hypereosinophilia|Hypereosinophilic Syndrome
Interventions: DRUG: mepolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Clinical Trial of AK105 Injection Combined With Anlotinib Hydrochloride Capsules Versus Sorafenib in Subjects With Advanced Hepatocellular Carcinoma (HCC)
Status: NOT_YET_RECRUITING
Conditions: Advanced Hepatocellular Carcinoma (HCC)
Interventions: DRUG: AK105 Injection|DRUG: Anlotinib Hydrochloride Capsules|DRUG: Sorafenib Tosylate Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Oxytocin vs. Carbetocin in Prevention of Postpartum Hemorrhage After Cesarean Section
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Carbetocin|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Fasting Study of Pioglitazone HCl Tablets 45 mg and Actos® Tablets 45 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pioglitazone HCl Tablets 45 mg|DRUG: Actos® Tablets 45 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of the Anticaries Efficacy of Dentifrice Formulations Using an In-situ Model
Status: COMPLETED
Conditions: Caries
Interventions: DRUG: Oral-B 1450 ppm Fluoride (1.16% sodium monofluorophosphate) Dentifrice|DRUG: Colgate 1450 ppm Fluoride (1.16% sodium monofluorophosphate)Dentifrice|DRUG: Toms of Maine 0 ppm Fluoride Dentifrice|DRUG: Colgate 1450 ppm Fluoride (1.1% sodium monofluorophosphate) Dentifrice|DRUG: 1500 ppm MFP/CaCO3 1.16% sodium monofluorophosphate) Dentifrice|DRUG: 1100 ppm (0.454% Stannous fluoride) Dentifrice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Glycine Therapy on Peri-implant Mucositis
Status: COMPLETED
Conditions: Peri-implant Mucositis
Interventions: PROCEDURE: glycine powder air-powered debridement|PROCEDURE: Ultrasonic instrumentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Activated Recombinant Human Factor VII in Treatment of Bleeding in Patients Following Allogeneic Stem Cell Transplantation
Status: COMPLETED
Conditions: Acquired Bleeding Disorder|Bleeding During/Following Surgery
Interventions: PROCEDURE: standard therapy|DRUG: activated recombinant human factor VII|DRUG: activated recombinant human factor VII|DRUG: activated recombinant human factor VII|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotic Toothpaste to Assess Microbial Colonization
Status: NOT_YET_RECRUITING
Conditions: Microbial Colonization
Interventions: OTHER: Streptococcus salivarius M18 toothpaste (1 million cfu)|OTHER: Streptococcus salivarius M18 toothpaste (10 million cfu)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of LNP3794 in Subjects With NRAS/KRAS Mutated Advanced or Metastatic Refractory Solid Tumors
Status: COMPLETED
Conditions: NRAS/KRAS Mutated Advanced or Metastatic Refractory Solid Tumors
Interventions: DRUG: LNP3794
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Combined Morphine and Duloxetine on Chronic Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain|Chronic Neck Pain
Interventions: DRUG: Morphine|DRUG: Duloxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Reducing Care-Resistant Behaviors During Oral Hygiene in Persons With Dementia
Status: COMPLETED
Conditions: Care-resistant Behavior|Dementia
Interventions: BEHAVIORAL: Care-resistant mouth care (MOUTh)|PROCEDURE: Evidence-based mouth care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Study of VIO-01 in Participants With Recurrent Solid Tumors
Status: RECRUITING
Conditions: Advanced or Metastatic Solid Tumors|Breast Cancer|Recurrent Ovarian Cancer|Prostate Cancer
Interventions: DRUG: VIO-01
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Combined Transcranial Magnetic Stimulation (TMS) and Cognitive Training in Alzheimer Patients
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)|BEHAVIORAL: NICE Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Medial Peel Release Technique TKA Randomized Clinical Trial
Status: TERMINATED
Conditions: Total Knee Arthroplasty|Osteoarthritis, Knee
Interventions: PROCEDURE: Medial Subperiosteal Release with Sharp Dissection|PROCEDURE: Medial Subperiosteal Release with Electrocautery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment of the Transfer of Using Levonorgestrel Intrauterine System (LNG IUS) as a Contraceptive to Using it as Part of Hormone Replacement Therapy (HRT).
Status: COMPLETED
Conditions: Menopause
Interventions: DRUG: LNG IUS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Hyperthermic Intraperitoneal Chemotherapy
Status: RECRUITING
Conditions: Colorectal Cancer|Peritoneal Metastases
Interventions: DRUG: 5Fluorouracil|DRUG: Irinotecan|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Supercharged End-to-Side Anterior Interosseous Nerve Transfer for Severe Cubital Tunnel Syndrome
Status: WITHDRAWN
Conditions: Cubital Tunnel Syndrome|Ulnar Nerve Compression|Ulnar Nerve Palsy|Ulnar Nerve Entrapment|Ulnar Nerve Entrapment at Elbow|Ulnar Nerve Entrapment Syndrome|Ulnar Neuropathies|Ulnar Claw
Interventions: PROCEDURE: Cubital tunnel release|PROCEDURE: Supercharged end-to-side (SETS) nerve transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Ritonavir Effects on Afatinib Exposure in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: afatinib|DRUG: ritonavir + afatinib|DRUG: ritonavir + afatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Two-Stage Phase 2 Study Of A-007 Topical Gel in High-Grade Squamous Intraepithelial Lesions (HSIL)
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia|Uterine Cervical Dysplasia
Interventions: DRUG: A-007
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arterial and End-Tidal CO2 Gradient as a Mortality Predictor in Critical Care Patients
Status: COMPLETED
Conditions: Critical Illness|Ventilation Perfusion Mismatch|Shock|Pulmonary Embolism|Trauma|Copd
Interventions: DIAGNOSTIC_TEST: EtCO2|DIAGNOSTIC_TEST: PaCO2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treat Arterial Hypertension and Diabetes in Rural Africa
Status: COMPLETED
Conditions: Diabetes|Arterial Hypertension
Interventions: OTHER: Treatment contract|OTHER: Tracing and recall at home by a community worker|OTHER: Incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Lesion Dosimetry With Iodine-124 in Metastatic Thyroid Carcinoma
Status: RECRUITING
Conditions: Thyroid Carcinoma|Metastatic Thyroid Carcinoma
Interventions: DEVICE: PET/CT Scan|DRUG: Iodine-124
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of a Mindfulness Program on Emotion Regulation Among Youth Attending an Alternative School
Status: COMPLETED
Conditions: Substance Use|Mindfulness|Adolescent Behavior|Emotion Regulation|Social Behavior|Self Esteem
Interventions: BEHAVIORAL: Mindfulness Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Estimate the Relative Bioavailability Compared to Commercial Extended-release Tablet Formulation and the Effects of Food Or Sprinkling on Applesauce for Fesoterodine Sustained-release Beads-in-capsule Formulations in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Fesoterodine ER (fasted)|DRUG: Fesoterodine SR3 (fasted)|DRUG: Fesoterodine SR3 (fed)|DRUG: Fesoterodine ER (fed)|DRUG: Fesoterodine SR3 (sprinkle)|DRUG: Fesoterodine ER (fasted)|DRUG: Fesoterodine SR4 (fasted)|DRUG: Fesoterodine SR4 (fed)|DRUG: Fesoterodine ER (fed)|DRUG: Fesoterodine SR4 (sprinkle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Copanlisib in Treating Patients With Persistent or Recurrent Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Endometrioid Adenocarcinoma|Endometrial Mixed Cell Adenocarcinoma|Endometrial Serous Adenocarcinoma|Endometrial Undifferentiated Carcinoma|Metastatic Endometrioid Adenocarcinoma|Recurrent Uterine Corpus Cancer
Interventions: DRUG: Copanlisib|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Plus Concurrent Nimotuzumab in Elderly Patients With Locoregionally Advanced Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Nimotuzumab|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Helping Our Premature Infants ON to Better Motor Skills (HOP-ON)
Status: COMPLETED
Conditions: Motor Development of Premature Infants
Interventions: OTHER: HOP-ON|OTHER: SMILES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pilot Evaluation of Closed Loop Ventilation and Oxygen Controller
Status: COMPLETED
Conditions: Cardiac Surgery|Mechanically Ventilated Patients
Interventions: DEVICE: Hamilton ventilator (G5 modify to S1) Automated settings|OTHER: Hamilton ventilator (G5) protocolized settings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Immunotherapy and Hyperthermia in Advanced Malignant Mesothelioma
Status: TERMINATED
Conditions: Cancer|Mesothelioma, Malignant
Interventions: DRUG: Anti-PD-1 antibody|BIOLOGICAL: DC-CIK Immunotherapy|DEVICE: Thermotron RF-8EX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sirolimus Eluting Stents in Complex Coronary Lesions (SCANDSTENT)
Status: COMPLETED
Conditions: Ischaemic Heart Disease
Interventions: DEVICE: Coronary Drug Eluting Stents for PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of High Frequency Electrical Currents in Healthy Subjects.
Status: COMPLETED
Conditions: High Frequency Current
Interventions: DEVICE: High-Frequency|DEVICE: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Lanabecestat (LY3314814) in Early Alzheimer's Disease Dementia
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: Lanabecestat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Different Injections Volumes of Botulinum Toxin Type A, Azzalure, in the Glabellar Lines
Status: COMPLETED
Conditions: Glabellar Frown Lines
Interventions: DRUG: Azzalure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rufinamide Given as Adjunctive Therapy in Participants With Refractory Partial Seizures
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Placebo|DRUG: Rufinamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Radiochemotherapy With Hyperthermia for Locally Advanced Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer|Locally Advanced Rectal Cancer|Hyperthermia|Hyperthermic Radiochemotherapy|Hyperthermic Chemoradiotherapy|Deep Regional Hyperthermia
Interventions: OTHER: Deep regional hyperthermia|RADIATION: Radiotherapy|DRUG: Chemotherapy (5-Fluorouracil)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the Effect of Isosorbide Mononitrate in Reducing Pain During Levonorgestrel-releasing Intrauterine Device Insertion
Status: UNKNOWN
Conditions: Contraception
Interventions: DRUG: Isosorbide Mononitrate 40 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I Study to Investigate Pharmacokinetics and Safety of BAY73-4506 in Asian (Japanese) Patients With Solid Tumors.
Status: COMPLETED
Conditions: Tumors
Interventions: DRUG: Regorafenib (BAY73-4506)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assess the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of RXC007 in Idiopathic Pulmonary Fibrosis
Status: ACTIVE_NOT_RECRUITING
Conditions: IPF|Fibrosis
Interventions: DRUG: RXC007|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Clinical Study of the Efficacy and Safety of HRS9950 Tablets in Chronic Hepatitis B Patients Who Are Virologically Suppressed on Nucleoside or Nucleotide Analogues (NAs)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Hepatitis B
Interventions: DRUG: HRS9950 tablets|DRUG: HRS9950 tablets|DRUG: HRS9950 placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Observed Long-acting, Anti-HIV Treatment With a Monoclonal CCR5 Antibody (PRO 140) as an Adjunct to a New, Optimized, Oral Antiretroviral Regimen in HIV-infected Injection Drug Users With Viral Rebound and Documented Poor Adherence
Status: WITHDRAWN
Conditions: HIV
Interventions: DRUG: PRO 140|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Proellex in Pre-menopausal Women With Symptomatic Uterine Fibroids
Status: COMPLETED
Conditions: Uterine Fibroids
Interventions: DRUG: 12.5 mg Proellex|DRUG: 25 mg Proellex|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of 2 Modalities of Dialysis and Nutrition on the Nutritional Status of Malnourished Chronic Renal Disease Patients
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: DIETARY_SUPPLEMENT: oral nutritional supplementation|DIETARY_SUPPLEMENT: intradialytic parenteral nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Analysis of the Effectiveness of Neoadjuvant Chemotherapy in the Treatment of Colon Cancer Locally Advanced (ELECLA)
Status: UNKNOWN
Conditions: Locally Advanced Colon Cancer
Interventions: COMBINATION_PRODUCT: CAPECITABINE AND OXALIPLATIN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Add-on Buprenorphine at Analgesic Doses for the Treatment of Severe Suicidal Ideas During a Major Depressive Episode
Status: RECRUITING
Conditions: Suicidal Ideation|Major Depressive Episode
Interventions: DRUG: Buprenorphine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Turkish Validation and Reliability of LURN SI-29 Questionnaire in Patients With Lower Urinary Tract Symptoms
Status: COMPLETED
Conditions: Lower Urinary Tract Symptoms|Urinary Incontinence
Interventions: OTHER: Lower Urinary Tract Dysfunction Research Network Symptom Index-29 (LURN SI-29)|OTHER: IPSS|OTHER: UDI-6
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Non-pharmacological Treatments in Migraine.
Status: TERMINATED
Conditions: Migraine
Interventions: OTHER: dual task protocol: active exercises with concomitant cognitive training in executive functions|OTHER: active exercise|OTHER: cognitive task only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Evaluation of Safety, Tolerability and Pharmacokinetics of Stroke Targeting Drug in Healthy Volunteers
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: JPI-289|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study in Adults to Investigate the Impact of Mild, Moderate, and Severe Hepatic Impairment on Pharmacokinetics of Venglustat Compared to Participants With Normal Hepatic Function
Status: COMPLETED
Conditions: Hepatic Function Abnormal
Interventions: DRUG: Venglustat (GZ402671)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Integra® Cadence™ Total Ankle System in Primary Ankle Joint Replacement (CADENCE)
Status: SUSPENDED
Conditions: Rheumatoid Arthritis|Degenerative Arthritis|Post Traumatic Arthritis
Interventions: DEVICE: Integra Cadence Total Ankle System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The COMACS Study: A Comparison of Methylphenidates in an Analog Classroom Setting
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Methylphenidate Extended Release Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparative Clinical Study Between Empagliflozin Versus Pioglitazone in Non-diabetic Patients With Non-alcoholic Steatohepatitis
Status: NOT_YET_RECRUITING
Conditions: Non Alcoholic Steatohepatitis
Interventions: DRUG: Pioglitazone 30mg|DRUG: Empagliflozin 10 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Comparison of the Four Biopsy Methods for Prostate Cancer Detection
Status: COMPLETED
Conditions: Prostate Cancer|Prostate Adenocarcinoma
Interventions: PROCEDURE: consequently performed 4 biopsy methods (TRUS-guided biopsy, cognitive, fusion and transperineal template mapping biopsy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ITACA-S2 (Intergroup Trial in Adjuvant Chemotherapy for Adenocarcinoma of the Stomach)
Status: TERMINATED
Conditions: Gastric Adenocarcinoma
Interventions: OTHER: peri-operative cht|OTHER: post-operative CHT|OTHER: peri-operative cht + post-operative cht-rtx|OTHER: post-operative cht + post-operative cht-rtx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Under-Represented Communities Diagnosed With SCD or MCI Through Tele-Cog
Status: NOT_YET_RECRUITING
Conditions: Mild Cognitive Impairment|Subjective Cognitive Decline
Interventions: BEHAVIORAL: Assessments|OTHER: Neuroimaging volumetric measures|OTHER: Biofluid samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevalence of Liver Fibrosis and Cirrhosis in Patients With Squamous Cell Carcinoma of the Head and Neck
Status: UNKNOWN
Conditions: Liver Fibroses|Liver Cirrhoses|Squamous Cell Carcinoma of the Head and Neck
Interventions: OTHER: Evaluation of the hepatic fibrosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparisons of iv Ibuprofen and iv Paracetamol During Bariatric Surgery
Status: COMPLETED
Conditions: Bariatric Surgery Candidate|Obesity, Morbid
Interventions: DRUG: paracetamol|DRUG: ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intermittent Theta Burst Stimulation (iTBS) for Alleviating Symptoms of Schizophrenia Patients
Status: COMPLETED
Conditions: Schizophrenia|Functional Magnetic Resonance Imaging|Transcranial Magnetic Stimulation
Interventions: DEVICE: transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety and Efficacy Study of Teduglutide in Pediatric Participants With Short Bowel Syndrome (SBS)
Status: COMPLETED
Conditions: Short Bowel Syndrome
Interventions: DRUG: TED|OTHER: SOC|DEVICE: Syringe|DEVICE: Needle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tarceva (Erlotinib) to Compare Two Different Doses in in Currently Smoking Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (CURRENTS)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Erlotinib [Tarceva]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Perioperative Analgesic Effect of Two Different Volumes of Local Anesthetic Solution in Erector Spinae Plane Block in Patients Undergoing Modified Radical Mastectomy
Status: COMPLETED
Conditions: Comparing of 2 Different Volumes in ESPB in Patients Undergoing MRM
Interventions: DRUG: Group 1(low concentration-high volume bupivacaine US guided Erector Spinae Plane block)|DRUG: Group 2(high concentration-low volumecbupivacaine US guided Erector Spinae Plane block)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Teledermatology on Length of Hospital Admission, Length of Stay, 30 Day Readmission Rate, and Antibiotic Use in Patients Presenting With Cellulitis vs Pseudocellulitis in an Academic ED Setting
Status: COMPLETED
Conditions: Cellulitis
Interventions: OTHER: teledermatology consult|OTHER: Routine Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Of The Safety And Efficacy Of PF-04191834 In Patients With Osteoarthritis Of The Knee
Status: TERMINATED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: PF-04191834|DRUG: PF-04191834 placebo|DRUG: Naproxen placebo|DRUG: PF-04191834 placebo|DRUG: PF-04191834|DRUG: Naproxen placebo|DRUG: PF-04191834|DRUG: Naproxen|DRUG: PF-04191834 placebo|DRUG: Naproxen|DRUG: PF-04191834 placebo|DRUG: PF-04191834
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Open-label Single-arm Study to Evaluate the Efficacy and Safety of ADSCs in Subjects With Liver Cirrhosis
Status: RECRUITING
Conditions: Liver Cirrhosis
Interventions: DRUG: GXHPC1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Pharmacokinetics of Brimonidine Tartrate 0.025%/Ketotifen Fumarate 0.035% Combination Ophthalmic Solution
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: rimonidine Tartrate 0.025%/Ketotifen Fumarate 0.035% Ophthalmic Solution (Combo)|DRUG: Vehicle of brimonidine tartrate 0.025%/ketotifen fumarate 0.035% ophthalmic solution
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chronic Obstructive Pulmonary Disease Transcription Factor and Cytokine Study
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Azithromycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Extent of Drug Interaction Between BMS-986278 and Ninetedanib, the Relative Bioavailability of BMS-986278 in Tablet and the Effect That Food Has on BMS-986278 in Tablet Formulations in Healthy Participants
Status: NOT_YET_RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: Nintedanib|DRUG: BMS 986278
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Olopatadine Eye Drops and Allergy Skin Testing
Status: COMPLETED
Conditions: Allergic Rhinitis|Allergic Conjunctivitis
Interventions: DRUG: olopatadine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of ISST in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Integrated Social Cognitive and Behavioral Skills Therapy|BEHAVIORAL: Neurocognitive Remediation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Evaluate the Effect of Two Microalgae Consumption on Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Experimental: Group 1: Spirulina platensis|DIETARY_SUPPLEMENT: Experimental: Group 2: Chlorella vulgaris|DIETARY_SUPPLEMENT: Placebo Comparator: Group 3: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Augmented Reality Feasibility for Non-invasive Preoperative Tracking in Breast Cancer Surgery
Status: NOT_YET_RECRUITING
Conditions: Subclinical Breast Cancer Lesion
Interventions: PROCEDURE: Additional MRI with gadolinium injection and 3D camera imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Driving Offenses of Adolescent Drinkers
Status: UNKNOWN
Conditions: Alcohol Consumption
Interventions: BEHAVIORAL: Brief group counseling|BEHAVIORAL: Community Counseling|BEHAVIORAL: Prototypic community service|BEHAVIORAL: Prototypic community service
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Validity of Palpation in Detecting the Site of Lesion in Diabetic Trigger Finger Patients.
Status: UNKNOWN
Conditions: Trigger Finger|Validity of Palpation
Interventions: DIAGNOSTIC_TEST: palpation - ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Repeatability of Static & Dynamic Composite Confocal Microscopy for Assessment of the Corneal Nerve Fiber Plexus in Early Diabetic Polyneuropathy
Status: COMPLETED
Conditions: Normal Eyes of Subjects Without Diabetes Mellitus|Subjects With Diabetes Mellitus Type 2 Without Coexisting DPN|Subjects With Diabetes Mellitus Type 2 With Coexisting Early to Moderate DPN
Interventions: DEVICE: HRT RCM|DEVICE: HRT RCM-E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study in Unsettled Infants Experiencing Feeding Intolerance
Status: COMPLETED
Conditions: Feeding Disorder
Interventions: OTHER: Experimental Formula|OTHER: Standard control formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Ozanimod (RPC1063) in Relapsing Multiple Sclerosis (MS)
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Ozanimod|DRUG: Interferon beta-1a|DRUG: Placebo to ozanimod|DRUG: Placebo to interferon beta-1a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comorbid Painful TMD Among Trigeminal Neuralgia
Status: ACTIVE_NOT_RECRUITING
Conditions: Trigeminal Neuralgia|Temporomandibular Disorder|Myofascial Pain|Trigeminal Neuropathy
Interventions: DIAGNOSTIC_TEST: Clinical appointment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Safety of SPARC0913 in Open Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: SPARC0913
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Topical Vitamin D Drop on Meibomian Gland Function in Patients With Meibomian Gland Dysfunction
Status: UNKNOWN
Conditions: Meibomian Gland Dysfunction
Interventions: DRUG: Topical Vitamin D eye drop|DRUG: Topical placebo eye drop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Health Effect of Canola Oil Consumption in Shift Workers
Status: UNKNOWN
Conditions: Shift-Work Related Sleep Disturbance|Metabolic Syndrome|Diet Modification|Work-Related Condition
Interventions: BEHAVIORAL: Intervention group|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Moringa Oleifera- Antiretroviral Pharmacokinetic Drug Interaction
Status: COMPLETED
Conditions: HIV
Interventions: DIETARY_SUPPLEMENT: Moringa oleifera|DRUG: Efavirenz 600mg|DRUG: Nevirapine 200Mg Oral Tablet
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase I Dose Escalation Study of RAD001 Administered in Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Everolmus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of Disitamab Vedotin Combined With RC98 in the Treatment of Subjects With HER2-expressing Locally Advanced or Metastatic Gastric Cancer (Including AEG)
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: RC48-ADC|DRUG: RC98
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence and Consequences of Urinary Incontinence in People With Chronic Pulmonary Diseases Referred for Pulmonary Rehabilitation
Status: RECRUITING
Conditions: Chronic Pulmonary Disease|Pulmonary Rehabilitation|Urinary Incontinence
Interventions: OTHER: Pulmonary rehabilitation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multicenter, Randomized, Double-Blind, Placebo Controlled, Efficacy Study on the Effects of Tolvaptan on Left Ventricular Dilatation in Congestive Heart Failure Patients
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: DRUG: Tolvaptan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Immunoglobulin After Relapse in Vasculitis
Status: TERMINATED
Conditions: ANCA + Vasculitides Relapsing Either Under Corticosteroid|and Immunosuppressant Therapies or After One Year|Post Treatment.
Interventions: DRUG: Intravenous immunoglobulins (human immunoglobulins G)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antihypertensive Treatment in Masked Hypertension for Target Organ Protection
Status: UNKNOWN
Conditions: Masked Hypertension
Interventions: DRUG: Allisartan Isoproxil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pembro and HER2Bi-Armed Activated T Cells in Treating Patients With Metastatic Castration Resistant Prostate Cancer
Status: COMPLETED
Conditions: Castration Levels of Testosterone|Castration-Resistant Prostate Carcinoma|Prostate Carcinoma Metastatic in the Bone|PSA Progression|Stage IV Prostate Adenocarcinoma AJCC v7
Interventions: BIOLOGICAL: HER2Bi-Armed Activated T Cells|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiac and Endothelial Function Response to Early Exercise Training After Coronary Artery Bypass Surgery
Status: COMPLETED
Conditions: Coronary Artery Bypass Grafting|Coronary Artery Disease|Cardiac Rehabilitation
Interventions: OTHER: Ventilatory Muscle Training (TREMVEN)|OTHER: Aerobic Training (AERO)|OTHER: Isometric Handgrip Training (ISO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of 611 in Chinese Adult Patients With Moderate-to-Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: 611 150mg|DRUG: 611 300mg|DRUG: 611 600mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopically-delivered Purastat to Treat Bleeding Caused by Radiation Proctopathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Radiation Proctopathy
Interventions: DEVICE: Purastat Arm|DRUG: Standard Care Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of the Use of the Nasal Spray of Patients With Recurrence of Glioblastoma
Status: WITHDRAWN
Conditions: Recurrent Glioblastoma|Gliosarcoma|Anaplastic Gliomas
Interventions: DRUG: Axitinib 1 MG|DRUG: Sunitinib 5 MG|DRUG: Pazopanib 5 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Immediate Implant Placement on Alveolar Ridge Preservation Techniques
Status: COMPLETED
Conditions: Post-Extraction Socket|Immediate Implant Placement|Alveolar Ridge Preservation
Interventions: DEVICE: Alveolar Ridge Preservation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Assess the Retention and Caries Preventive Effects of Moisture Tolerant Resin Sealant and ART Sealants
Status: COMPLETED
Conditions: Retention
Interventions: OTHER: ART Sealant Application|OTHER: Resin sealant application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Continued Antiretroviral Therapy With Abacavir, Amprenavir and Efavirenz
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: Abacavir|DRUG: Amprenavir|DRUG: Efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Negative Pressure Wound Therapy -PREVENA in Prevention of Infections After Total Knee Arthroplasty (TKA)
Status: UNKNOWN
Conditions: Total Knee Replacement
Interventions: DEVICE: Negative Pressure Wound Therapy (NPWT)|DRUG: standard prophylactic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Stellate Ganglion Block Can Cause Enhanced Recovery After Coronary Arteries Bypass Grafting Surgery
Status: COMPLETED
Conditions: Ischemic Heart Disease
Interventions: OTHER: ultrasound guided left stellate ganglion block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Yoga on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy)
Status: RECRUITING
Conditions: Chemotherapy-Induced Peripheral Neuropathy
Interventions: OTHER: Yoga|OTHER: Education control|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT