pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Ibrutinib as an Immune Modulating Agent for Patients With Asymptomatic, High-risk CLL/SLL Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: BIOLOGICAL: Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine Adsorbed|DRUG: Ibrutinib|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|BIOLOGICAL: Pneumococcal 13-valent Conjugate Vaccine|OTHER: Quality-of-Life Assessment|BIOLOGICAL: Trivalent Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility of ActivSight(tm) in the Identification of The Ureter Via Riboflavin Fluorescence
Status: WITHDRAWN
Conditions: Surgical Procedure, Unspecified
Interventions: DEVICE: Investigational Safety and Feasibility
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Clinical Trial to Evaluate Efficacy and Safety of Dupilumab in Localized Scleroderma
Status: RECRUITING
Conditions: Localized Scleroderma
Interventions: DRUG: Dupilumab 300Mg Solution for Injection|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Music Therapy on Near-infrared Spectroscopy and Electroencephalogram in Premature Infants
Status: COMPLETED
Conditions: Preterm Infant|Music|Near-infrared Spectroscopy|Electroencephalogram
Interventions: OTHER: music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Magnification Narrow Band Imaging Colonoscopy for Hereditary Non-Polyposis Colorectal Cancer Surveillance
Status: COMPLETED
Conditions: Colorectal Neoplasms, Hereditary Nonpolyposis
Interventions: PROCEDURE: Narrow Band Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Etanercept in Patients With Plaque Psoriasis After Stopping Ciclosporin Therapy
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Etanercept|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Single and Multiple Doses Safety, Tolerability, Pharmacokinetics and Food Effect Study of KVD824 in Healthy Volunteers
Status: COMPLETED
Conditions: Hereditary Angioedema
Interventions: DRUG: KVD824|DRUG: Placebo to KVD824
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Two Tetanus-Diphtheria Vaccines for a Donor Hyper Immunization Program
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Tetanus and Diphtheria (Td) Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pelvic Floor Physical Therapy vs Standard Care in Transgender Women Undergoing Vaginoplasty for Gender Affirmation
Status: COMPLETED
Conditions: Pelvic Floor Disorders
Interventions: OTHER: Pelvic Floor Physical Therapy (PFPT)|OTHER: No Pelvic Floor Physical Therapy (PFPT)|OTHER: Preoperative PFPT and Postoperative PFPT|OTHER: Cross-over Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Hypothermia With Propofol in Survival and Neurological Prognoses After Cardiac Arrest
Status: UNKNOWN
Conditions: Hypothermia|Cardiac Arrest
Interventions: DRUG: Propofol|DRUG: Lorazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Neoadjuvant Durvalumab Plus Docetaxel, Oxaliplatin, S-1 Followed by Surgery and Adjuvant Durvalumab Plus S-1 Chemotherapy in Potentially Resectable MMR Proficient Gastric or Gastroesophageal Junction Adenocarcinoma
Status: RECRUITING
Conditions: Resectable Gastric or Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Docetaxel, Oxaliplatin, S-1 and Durvalumab|DRUG: Durvalumab and Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gestational Treatment With Ursodeoxycholic Acid Compared to Placebo to Reduce Severity of Gestational Diabetes Mellitus Diagnosed at 24-28 Weeks' Gestation
Status: COMPLETED
Conditions: Gestational Diabetes
Interventions: DRUG: 500 mg of ursodeoxycholic acid (UDCA)|OTHER: 500 mg of Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics (PK) of hOKT3g1 (Ala-Ala) in Type 1 Diabetes Mellitus (T1DM)
Status: COMPLETED
Conditions: Diabetes Mellitus, Insulin-Dependent
Interventions: DRUG: hokt3g1 (ALA-ALA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of BIA 9-1067 in Idiopathic Parkinson's Disease Patients.
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: BIA 9-1067|DRUG: Placebo|DRUG: Levodopa|DRUG: Carbidopa|DRUG: Benserazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remote Monitoring of CGM Data in Pediatric Patients With Newly Diagnosed Type 1 Diabetes (T1D)
Status: ENROLLING_BY_INVITATION
Conditions: Type 1 Diabetes
Interventions: OTHER: Integration with Epic
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of TAK-700 in Combination With Docetaxel and Prednisone in Men With Metastatic Castration-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: TAK-700|DRUG: Docetaxel|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Intravenous Infusion of Fucosylated Bone Marrow Mesenchyme Cells in Patients With Osteoporosis
Status: COMPLETED
Conditions: Osteoporosis|Spinal Fractures
Interventions: BIOLOGICAL: Fucosylated MSC for Osteoporosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Exercises Based on the Pilates in Coronary Artery Bypass Grafting
Status: UNKNOWN
Conditions: Cardiovascular Diseases
Interventions: OTHER: Pilates|OTHER: Conventional Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Abdominal Closure Bundle to Reduce Surgical Site Infection in Patients Undergoing C-sections. Cesarean Section Lead to Reduction in Surgical Site Infection? - A Randomized Controlled Trial
Status: UNKNOWN
Conditions: Surgical Site Infection|Cesarean Section; Infection
Interventions: PROCEDURE: Abdominal Closure Bundle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Endocuff-assisted Colonoscopy vs Standard Colonoscopy on Adenoma Detection Rate
Status: COMPLETED
Conditions: Colonic Adenoma|Colonic Polyp|Colonoscopy
Interventions: DEVICE: Endocuff Vision (ECV) second generation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Amoxicillin Clavulanate in Treatment of Acute Otitis Media
Status: UNKNOWN
Conditions: Acute Otitis Media
Interventions: DRUG: amoxicillin-clavulanate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Combination of Nivolumab and Axatilimab in Patients With Relapsed/Refractory Classical Hodgkin Lymphoma
Status: RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: DRUG: Axatilimab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Neoadjuvant Olaparib Monotherapy and Olaparib and Durvalumab Combination in HER2 Negative BRCAm Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Neoadjuvant Olaparib monotherapy group|COMBINATION_PRODUCT: Neoadjuvant combination therapy with olaparib plus durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immuno-persistence Study of a Recombinant Human Papillomavirus 16/18 Bivalent Vaccine in Preadolescent Girls
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia|Cervical Cancer|Vaginal Intraepithelial Neoplasia|Vulvar Intraepithelial Neoplasia|Persistent Infection
Interventions: PROCEDURE: 3 doses of HPV 16/18 bivalent vaccine|PROCEDURE: 2 doses of HPV 16/18 bivalent vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rocket® Pleural Catheters: QOL, Feasibility and Satisfaction in Recurrent MPE Patients
Status: UNKNOWN
Conditions: Malignant Pleural Effusion
Interventions: DEVICE: Rocket® IPC- Long External Length|DEVICE: Rocket® IPC- Short External Length
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CYCLONES - CYClophosphamide LOw Dose and No Extra Steroid
Status: TERMINATED
Conditions: Systemic Lupus Erythematosus (SLE)
Interventions: DRUG: Cyclophosphamide|DRUG: Methylprednisolone|DRUG: Prednisone|DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Intra-Ophthalmic Artery Topotecan Infusion for the Treatment of Retinoblastoma
Status: TERMINATED
Conditions: Retinoblastoma
Interventions: DRUG: Intra-Ophthalmic Artery Topotecan Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benefits of Tablet-based Serious Games to Promote Speech Production in Young Children With Hearing Disabilities
Status: COMPLETED
Conditions: Deafness|Hearing Loss
Interventions: BEHAVIORAL: FunSpeech|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of IDEC-114 in Combination With Rituxan in the Treatment of Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: IDEC-114
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Chiropractic Plus Nutritional Supplement in Patients With Chronic Pain and Inflammation.
Status: COMPLETED
Conditions: Chronic Pain|Inflammatory Response
Interventions: DIETARY_SUPPLEMENT: Nutritional Supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Mepolizumab-based Regimen Compared to Conventional Therapeutic Strategy in Patients With Eosinophilic Granulomatosis With Polyangiitis (E-merge)
Status: RECRUITING
Conditions: Eosinophilic Granulomatosis With Polyangiitis
Interventions: DRUG: Mepolizumab|DRUG: cyclophosphamide/azathioprine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Vagus Nerve Stimulation in Private Healthcare Center
Status: COMPLETED
Conditions: Generalized Anxiety Disorder|Chronic Pain|Irritable Bowel Syndrome
Interventions: DEVICE: Transcutaneous Vagus Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Fludarabine, Cytarabine (ARA-C) and Erwinase IV in Patients With Relapsed or Refractory Hematologic Malignancies
Status: WITHDRAWN
Conditions: Hematologic Malignancy
Interventions: DRUG: Fludarabine|DRUG: Cytarabine|DRUG: Erwinase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ziconotide as First-Line IDT
Status: COMPLETED
Conditions: Neuropathic Pain
Interventions: DRUG: Ziconotide 100 MCG(microgram)/ML Intrathecal Solution|DIAGNOSTIC_TEST: Quantitative sensory testing|DIAGNOSTIC_TEST: Serum markers: Interleukin-1, Interleukin-6, and tumor necrosis factor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of the Efficacy of Oral Versus Intravenous Hydration as a Preventive Measure of Contrast-induced Nephropathy (CIN) in Patients With Renal Insufficiency (RI) Grade III Under Study Conducting Computed Tomography (CT)
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: OTHER: Oral hydratation|DRUG: Bicarbonate endovenous hydratation|DRUG: Saline endovenous hydratation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bortezomib and Vorinostat in Younger Patients With Refractory or Relapsed MLL Rearranged Hematologic Malignancies
Status: TERMINATED
Conditions: Mixed Lineage Acute Leukemia|Acute Myeloid Leukemia|Acute Lymphoid Leukemia
Interventions: DRUG: Bortezomib|DRUG: Vorinostat|DRUG: Mitoxantrone|DRUG: Cytarabine|DRUG: Methotrexate|DRUG: Hydrocortisone|DRUG: Peg-L-Asparaginase|DRUG: Erwinia L-Asparaginase|DRUG: Dexamethasone|DRUG: Mercaptopurine|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Essential Oil Effect on Common QOL Concerns During Cancer Treatment
Status: COMPLETED
Conditions: Gastrointestinal Cancer|Neuroendocrine Carcinoma|Skin Cancer
Interventions: PROCEDURE: Aromatherapy and Essential Oils|PROCEDURE: Aromatherapy and Essential Oils|PROCEDURE: Aromatherapy and Essential Oils|PROCEDURE: Aromatherapy and Essential Oils|OTHER: Subject Diary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: I-PRF After Arthrocentesis Plus Botox Injection to Lateral Pterygoid Muscle in Treatment of Anterior Disc Displacement
Status: NOT_YET_RECRUITING
Conditions: TMJ Disc Disorder|TMJ Pain
Interventions: DRUG: TMJ Arthrocentesis Followed By Injectable Platelet Rich Fibrin And Botulinum Toxin Type A|DRUG: TMJ Arthrocentesis Followed By Injectable Platelet Rich Fibrin|DRUG: TMJ Arthrocentesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Liraglutide on Heart Frequency in Healthy Volunteers
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: placebo|DRUG: moxifloxacin|DRUG: placebo|PROCEDURE: electrocardiogram (ECG)|PROCEDURE: electrocardiogram (ECG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intermittent Oro-esophageal Tube Feeding on Dysphagia in Stroke Survivor
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: DEVICE: Intermittent Oro-esophageal Tube Feeding|BEHAVIORAL: comprehensive rehabilitation therapy|DEVICE: Nasogastric Tube Feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 10-day Versus 14-day Concomitant PAMC as First-line Treatment Strategy for the Eradication of H. Pylori Infection
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Amniotic Fluid Product in Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: OTHER: Amniotic Fluid 4.0ml dose|OTHER: Amniotic Fluid 2.0ml dose|OTHER: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial Evaluating EARLY Application of a Surfactant Dressing in Thermal Injury (EARLY)
Status: COMPLETED
Conditions: Burns|Partial-thickness Burn
Interventions: DEVICE: WSD|DEVICE: Dressed with bacitracin and petrolatum gauze
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multiple Dose Study of LY3023703 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Placebo|DRUG: LY3023703|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Comparing Two Stop Smoking Intervention Efficacies
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: NHS 1-1 smoking cessation programme.|BEHAVIORAL: Group smoking cessation programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Hematological Factors and Iron Status in Aerobic Versus Anaerobic Training in Athletic Females
Status: COMPLETED
Conditions: Sports Anemia
Interventions: OTHER: evaluating blood levels of hemoglobin, hematocrit, red blood cell count, mean corpuscular volume, mean corpuscular hemoglobin concentration, serum transferrin and serum ferritin.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cilengitide (EMD 121974) in Treating Patients With Advanced Solid Tumors or Lymphoma
Status: COMPLETED
Conditions: AIDS-related Peripheral/Systemic Lymphoma|AIDS-related Primary CNS Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Splenic Marginal Zone Lymphoma|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Mycosis Fungoides/Sezary Syndrome|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Mycosis Fungoides/Sezary Syndrome|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: cilengitide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prognostic Factors Affecting Outcomes in Multivisceral en Bloc Resection for Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: PROCEDURE: Multivisceral en bloc resection surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tooth Whitening Evaluation With Cytotoxic and Genotoxic Effect of Commercial Whitening Toothpastes on Oral Mucosal Cells
Status: UNKNOWN
Conditions: Teeth Whitening
Interventions: OTHER: Control group|OTHER: Whitening toothpaste 1|OTHER: Whitening toothpaste 2|OTHER: Whitening toothpaste 3|OTHER: Whitening toothpaste 4|OTHER: Whitening toothpaste 5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Multicenter Clinical Trial of Stool-based DNA Testing for Early Detection of Colon Cancer in China
Status: COMPLETED
Conditions: Colorectal Cancer|Advanced Adenocarcinoma|Hyperplastic Polyp|Colorectal Neoplasms|Digestive System Neoplasm|Neoplasms
Interventions: DIAGNOSTIC_TEST: Multigene Methylation Detection Kit
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Chronic Low Back Pain Treatment on Temporomandibular Disorder"
Status: NOT_YET_RECRUITING
Conditions: Temporomandibular Disorder|Chronic Low-back Pain
Interventions: OTHER: Therapeutic Group|OTHER: Rocabado's Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes of 36 vs 38 Hour Intervals From Ovulation Trigger To Oocyte Pick-Up:A Multi-Center Randomized Controlled Trial
Status: RECRUITING
Conditions: Infertility|IVF
Interventions: OTHER: 36-hour duration between ovulation triggering and oocyte pick-up procedure|OTHER: 38-hour duration between ovulation triggering and oocyte pick-up procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of SHR-1702 Alone or With Camrelizumab in Participants With Advanced Relapsed/Refractory Solid Tumors
Status: TERMINATED
Conditions: Advanced Solid Tumor
Interventions: DRUG: SHR-1702|DRUG: Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Erythropoietin Treatment Versus Placebo on Quality-of-life in Patients With Advanced Prostate Cancer.
Status: COMPLETED
Conditions: Prostate|Carcinoma
Interventions: DRUG: Epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertrophic Cardiomyopathy|Obstructive Hypertrophic Cardiomyopathy|Non-obstructive Hypertrophic Cardiomyopathy
Interventions: DRUG: mavacamten
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of an Easy to Read Advance Directive Versus a Standard Advance Directive
Status: COMPLETED
Conditions: Aging
Interventions: BEHAVIORAL: AD-Easy (Advance Directive-Easy)|BEHAVIORAL: AD-Standard (Advance Directive-Standard)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose:
Clinical trial: Attractive Targeted Sugar Bait Phase III Trial in Zambia
Status: ACTIVE_NOT_RECRUITING
Conditions: Malaria|Malaria,Falciparum|Vector-Borne Transmission of Infection
Interventions: OTHER: Attractive Targeted Sugar Bait
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Toripalimab Plus Actinomycin-D as Fist-Line Treatment for GTN With FIGO Score 7
Status: NOT_YET_RECRUITING
Conditions: Gestational Trophoblastic Neoplasia
Interventions: DRUG: Toripalimab|DRUG: Actinomycin-D
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of CDX 6114 in PKU Patients
Status: WITHDRAWN
Conditions: Phenylketonurias
Interventions: DRUG: cohort 1 0.225g|DRUG: Cohort 2 0.75g|DRUG: Cohort 3 2.25 g
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Four Orthotic Insoles on Pain in the Lower Body Associated With Musculoskeletal Stress
Status: TERMINATED
Conditions: Musculoskeletal Pain
Interventions: DEVICE: Orthotic Insole: Lower Back|DEVICE: Orthotic Insole: Heel|DEVICE: Orthotic Insole: Knee to Heel|DEVICE: Orthotic Insole: Arch
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease|Movement Disorders|Neurodegeneration
Interventions: BEHAVIORAL: HV-PDAE: High Volume Partnered Dance Aerobic Exercise|BEHAVIORAL: MV-PDAE: Moderate Volume Partnered Dance Aerobic Exercise|BEHAVIORAL: MV-WALK: Moderate Volume Walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Chair Seat Height on the 1-Minute Sit to Stand Test Performance in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: COPD|Chronic Obstructive Pulmonary Disease
Interventions: OTHER: 1-min STS test: adjusted|OTHER: 1-min STS test: standardized
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Phase II Trial of Combination Immunotherapy in Subjects With Advanced Small Bowel and Colorectal Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Small Bowel Cancers|Colorectal Cancers
Interventions: BIOLOGICAL: CV301|DRUG: MSB0011359C|DRUG: N-803|DRUG: NHS-IL12
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Motor Training and White Matter in Multiple Sclerosis (MS)
Status: TERMINATED
Conditions: Multiple Sclerosis
Interventions: DEVICE: tDCS|BEHAVIORAL: Bimanual Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Ferric Carboxymaltose Injection in Participants With Iron Deficiency Anaemia
Status: COMPLETED
Conditions: Iron Deficiency|Anaemia
Interventions: DRUG: Ferric Carboxymaltose Injection|DRUG: Ferric Carboxymaltose Injection [Ferinject]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study of TAK-850 Subcutaneous Injection in Healthy Adults
Status: COMPLETED
Conditions: Influenza Infection
Interventions: DRUG: Subcutaneous injection of TAK-850|DRUG: Intramuscular injection of TAK-850
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Long-term Incidence of Ventricular Arrhythmias in Patients With Acute Myocarditis
Status: UNKNOWN
Conditions: Myocarditis Acute|Ventricular Arrythmia
Interventions: DEVICE: Biomonitor|DEVICE: Life Vest|DEVICE: Implantable Cardioverter-Defibrillator (ICD)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of Rehabilitation in Phase 1 After Coronary Artery Bypass Grafting
Status: COMPLETED
Conditions: Ischaemic Heart Disease
Interventions: BEHAVIORAL: Exercise training component|BEHAVIORAL: Psycho-educative component
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Dupilumab Chronic Hands Eczema Refractory to Highly Potent Topical Corticosteroids
Status: RECRUITING
Conditions: Chronic Hand Eczema
Interventions: DRUG: Dupilumab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adolescent Nutrition in Girls in Burkina Faso and Ethiopia
Status: RECRUITING
Conditions: Nutrition Deficiency Due to Insufficient Food
Interventions: DIETARY_SUPPLEMENT: BEP supplement|DIETARY_SUPPLEMENT: Multiple Micronutrient supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Berberine Effects on Clinical Symptoms and Metabolic Disturbance in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Therapeutics
Interventions: DRUG: Berberine|DRUG: atypical antipsychotic|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Partial Breast Versus no Irradiation for Women With Early Breast Cancer
Status: RECRUITING
Conditions: Local Neoplasm Recurrence|Distantly Metastatic Malignant Neoplasm|Death|Fibrosis Breast|Depigmentation/Hyperpigmentation of Skin|Telangiectasia|Scar|Pain|PROMs
Interventions: RADIATION: No partial breast irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of VX-765 in Subjects With Treatment-resistant Partial Epilepsy
Status: COMPLETED
Conditions: Partial Epilepsy
Interventions: DRUG: VX-765
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Probable Benefit of the Neuro-Spinal Scaffold™ in Subjects With Complete Thoracic AIS A Spinal Cord Injury as Compared to Standard of Care
Status: TERMINATED
Conditions: Injury, Spinal Cord
Interventions: DEVICE: Neuro-Spinal Scaffold
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Image Quality Between Ultra-low Dose (ULD) and Standard Dose CT Scans in Detecting Traumatic Brain Injury in the Emergency Room
Status: UNKNOWN
Conditions: Closed Head Injury|Penetrating Head Injury
Interventions: DIAGNOSTIC_TEST: CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Modulating Surgery-Induced Blood-Brain Barrier Disruption in Elderly
Status: RECRUITING
Conditions: Delirium, Postoperative
Interventions: DRUG: Dexmedetomidine Injection [Precedex]|DRUG: Lidocaine IV|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Second-look Endoscopy in High Risk Patients After Endoscopic Hemostasis to Their Bleeding Peptic Ulcers Improves Their Outcomes
Status: TERMINATED
Conditions: Ulcer Bleeding
Interventions: PROCEDURE: epinephrine injection or heater probe or hemoclips|OTHER: Observation only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity
Status: RECRUITING
Conditions: Generalized Anxiety Disorder|Panic Disorder|Social Anxiety Disorder|Alcohol Use Disorder|Depression
Interventions: BEHAVIORAL: Negative Emotions and Addiction Tools Program (NEAT)- Cognitive Behavioral Therapy|BEHAVIORAL: Progressive Muscle Relaxation Training (PMRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Pulse Co-oximetry for Detecting Carbon Monoxide Poisoning in the Prehospital Emergency Medical Service Setting
Status: UNKNOWN
Conditions: Carbon Monoxide Poisoning
Interventions: DEVICE: RAD57 measurement (SpCO)|DEVICE: CO-oximeter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Inspiratory Muscle Training After Lung Cancer Surgery, a Randomized Controlled Trial
Status: COMPLETED
Conditions: Lung Cancer|Surgery
Interventions: OTHER: Inspiratory muscle training|OTHER: Placebo comparator: standard physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Feasibility of Olanzapine at REduced doSe in hIGHly Emetogenic chemoTherapy
Status: COMPLETED
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: DRUG: Zyprexa® (OLANZapine 5MG)|DRUG: Emend® (Aprepitant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial for Peroperative Procedure and Postoperative Pain After Rectal Misoprostol or Rectal Hyoscine Administration
Status: COMPLETED
Conditions: Hysteroscopic Surgery|Pain, Postoperative
Interventions: DRUG: Misoprostol|DRUG: Hyoscine butyl bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase I Trial of Vorinostat in Combination With Bevacizumab & Irinotecan in Recurrent Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: Vorinostat|DRUG: Bevacizumab|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positive and Expiratory Pressure and Hemorrhagic Stroke
Status: COMPLETED
Conditions: Stroke|Hemorrhage
Interventions: OTHER: lung mechanics ventilatory|OTHER: Hemodynamic and intracranial pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of the Apyx™ Device for the Repair of Pelvic Organ Prolapse (POP)
Status: COMPLETED
Conditions: Pelvic Organ Prolapse
Interventions: DEVICE: Apyx device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Eribulin Plus Lapatinib in Patients With Metastatic Breast Cancer (E-VITA)
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Lapatinib + 1,23 mg Eribulin|DRUG: Lapatinib + 1,76 mg Eribulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer|Advanced Solid Tumors|Triple-Negative Breast Cancer (TNBC)|Non-small-cell-lung-cancer (NSCLC)|Metastatic Solid Tumors
Interventions: DRUG: ABBV-927|DRUG: ABBV-368|DRUG: ABBV-181|DRUG: Carboplatin|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BPI-7711 Capsule in Patients With EGFR Mutation T790M Positive Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: BPI-7711 Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preliminary Effectiveness of Individual and Group MDMA-assisted Therapy for Israeli Veterans With PTSD and Moral Injury.
Status: NOT_YET_RECRUITING
Conditions: Post Traumatic Stress Disorder|Moral Injury|MDMA ('Ecstasy')
Interventions: DRUG: methylenedioxymethamphetamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conversion Prograf® to Advagraf® at D7 Versus D90 After Liver Transplantation
Status: COMPLETED
Conditions: Immunosuppression After Liver Transplantation
Interventions: DRUG: Conversion at day 7 ± 3 Prograf® to Advagraf®|DRUG: Conversion at day 90±5 Prograf® to Advagraf®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Superior Hypogastric Nerve Block for Pain Control Post-uterine Fibroid Embolization
Status: COMPLETED
Conditions: Leiomyoma
Interventions: PROCEDURE: Superior hypogastric nerve block|DRUG: 0.75% Ropivacaine|PROCEDURE: Subcutaneous injection|DRUG: 1% Xylocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Advanced Provision Emergency Contraception Among Women With Gonorrhea or Chlamydia
Status: COMPLETED
Conditions: Pregnancy
Interventions: DRUG: levonorgestrel 0.75mg taken twice 12 hours apart (Plan B) and condoms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Recurrent Crying Spells in Cerebral Palsy
Status: COMPLETED
Conditions: Recurrent Crying Spells
Interventions: DRUG: Baclofen|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Project Engage: A Wrist Biosensor-based mHealth Suite to Support Alcohol Intervention in Young People Living With HIV
Status: RECRUITING
Conditions: HIV
Interventions: BEHAVIORAL: eWrapper-Engagement strategies to facilitate alcohol biosensor wearing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effectiveness of Resistive Capacitive Diathermy in Patients Affected by Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: resistive capacitive diathermy treatment (resistive capacitive diathermy, Hcr 902, Unibell)|OTHER: sham placebo resistive capacitive diathermy treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BIG 02/98 Docetaxel - Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Doxorubicine + docetaxel sequential|DRUG: doxorubicine + cyclophosphamide sequential|DRUG: doxorubicine + cyclophosphamide combined|DRUG: doxorubicine + docetaxel combined
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Intervention Study to Improve HRQoL and Exercise Tolerance After Lung Transplantation (Ergo-LTx)
Status: UNKNOWN
Conditions: Lung Transplantation
Interventions: BEHAVIORAL: exercise training; psychosocial support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Brain MRF in Children, Adolescents and Young Adults With Acute Leukemia
Status: NOT_YET_RECRUITING
Conditions: Acute Leukemia|Acute Lymphoblastic Leukemia, Pediatric|Acute Myeloid Leukemia in Children|Myeloproliferative Neoplasm
Interventions: OTHER: MRF with neurocognative studies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Selecting Treatment in Colorectal Cancer:Capecitabine or 5-fluorouracil Selection to be Combined With Oxaliplatin or Irinotecan as First-line Chemotherapy in Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: BVZ+XELOX or BVZ+XELIRI or BVZ+FUIRI or BVZ+FUOX|DRUG: BVZ+XELOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization of the Patient Care Pathway in Immuno-oncology
Status: COMPLETED
Conditions: Melanoma
Interventions: OTHER: Dedicated and coordinated e-follow-up during the treatment period|OTHER: Standard follow-up during the treatment period
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pilot Study of Aprepitant Effect on Aldosterone Secretion in Diabetic Patient (Diabetes Mellitus) With Hypertension Associated With Low Renin
Status: UNKNOWN
Conditions: Type 2 Diabetes|Hypertension
Interventions: BIOLOGICAL: Blood sampling|PROCEDURE: Blood Pressure Measurement|DEVICE: electrocardiogram|PROCEDURE: orthostatic test|DRUG: Administration of Aprepitant|DRUG: Administration of placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 18F-FDG PET/CT-based Prognostic Model for Predicting Outcome in Patients With Natural Killer/T-cell Lymphoma
Status: UNKNOWN
Conditions: Lymphoma, Extranodal NK-T-Cell
Interventions: DEVICE: 18F-FDG PET/ CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Enhanced Daily Disinfection on Environmental Contamination in Hospital Rooms
Status: RECRUITING
Conditions: Disinfection
Interventions: OTHER: Sani24|OTHER: Standard EPA-registered disinfectant|OTHER: Routine Disinfection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Test the Efficacy of the Vaccine GSK 249553 in Treating Non-small-cell Lung Cancer After Tumour Removal by Surgery
Status: COMPLETED
Conditions: Lung Cancer, Non-Small Cell
Interventions: BIOLOGICAL: GSK 249553 vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Biweekly Ranibizumab (0.5 mg) for Exudative Macular Degeneration Retinal Edema Refractory to Anti-VEGF
Status: COMPLETED
Conditions: Exudative Age Related Macular Degeneration
Interventions: DRUG: Ranibizumab Injection [Lucentis]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dose-Rate Brachytherapy for the Treatment of Both Primary and Secondary Unresectable Liver Malignancies
Status: RECRUITING
Conditions: Liver Malignant Tumors|Cholangiocarcinoma Metastatic|Pancreatic Cancer|Melanoma
Interventions: DEVICE: high dose rate brachytherapy|DEVICE: high dose rate brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MBSR in Rheumatoid Arthritis Patients With Controlled Disease But Persistent Depressive Symptoms
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Depressive Symptoms
Interventions: BEHAVIORAL: Mindfulness-Based Stress Reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nasotracheal Intubation Over a Bougie
Status: COMPLETED
Conditions: Nasotracheal Intubation|Nasal Bleeding
Interventions: PROCEDURE: Nasotracheal intubation over a bougie|PROCEDURE: Conventional Nasotracheal Intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Actual Human Use of Methotrexate (MTX) Subcutaneously Administered Via the VIBEX™ MTX Auto-Injector Device
Status: COMPLETED
Conditions: Rheumatoid Arthritis (RA)
Interventions: DEVICE: VIBEX MTX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Drug-drug Interaction of Omega-3 and Atorvastatin
Status: UNKNOWN
Conditions: Hyperlipidemia, Hypertriglyceridemia
Interventions: DRUG: Omacor|DRUG: Pritor|DRUG: Omacor + Pritor|DRUG: Pritor + Omacor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER