pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety, Tolerability and Immunogenicinity of a Coronavirus-Like Particle COVID-19 Vaccine in Adults Aged 18-55 Years.
Status: COMPLETED
Conditions: SARS-CoV 2
Interventions: BIOLOGICAL: Intramuscular Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Drug Interaction Study of Famotidine and Atazanavir With Ritonavir in HIV-Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Atazanavir/Ritonavir|DRUG: Atazanavir/Ritonavir + Famotidine|DRUG: Atazanavir/Ritonavir + Famotidine|DRUG: Atazanavir/Ritonavir|DRUG: Atazanavir/Ritonavir + Tenofovir Disproxil Fumrarate + Famotidine|DRUG: Atazanavir/Ritonavir + Tenofovir Disproxil Fumrarate + Famotidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Renal PRotection Against Contrast mEdium-induced nephroPathy in High Risk Patients undErgoing Coronary Angiography
Status: COMPLETED
Conditions: Renal Insufficiency|Contrast Medium-induced Renal Insufficiency
Interventions: PROCEDURE: Coronary Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Intrapleural Bupivacaine for Ipsilateral Shoulder Pain After Thoracotomy
Status: COMPLETED
Conditions: Post Thoracic Surgery
Interventions: DRUG: Bupivacaine-epinephrine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Different Doses of Clonidine to Fentanyl as an Adjuvant to Bupivacaine 0.5% for Spinal Anesthesia
Status: WITHDRAWN
Conditions: Full Term Pregnant Patients|Undergoing Lower Segment Caesarian Section
Interventions: DRUG: Fentanyl|DRUG: Clonidine|DRUG: Clonidine|DRUG: clonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Short-Term Cultured Anti-Tumor Autologous Lymphocytes After Lymphocyte-Depleting Chemotherapy in Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma|Malignant Melanoma|Melanoma, Experimental|Experimental Melanomas
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: therapeutic autologous lymphocytes|DRUG: Cyclophosphamide|DRUG: Fludarabine phosphate|RADIATION: Total body irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Response to GSK Biologicals' Tritanrix-HepB/Hib-MenAC Vacc (4th Dose) at 15-24m & Mencevax ACWY at 24-30m
Status: COMPLETED
Conditions: Whole Cell Pertussis|Haemophilus Influenzae Type b|Hepatitis B|Diphtheria|Tetanus|Diphtheria-Tetanus-Pertussis-Hepatitis B-Haemophilus Influenzae Type b-Neisseria Meningitidis Vaccin
Interventions: BIOLOGICAL: Tritanrix-HepB/Hib-MenAC|BIOLOGICAL: Mencevax ACWY|BIOLOGICAL: Tritanrix-HepB/Hiberix|BIOLOGICAL: Meningitec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Prophylactic Phenobarbital After Neonatal Seizures
Status: TERMINATED
Conditions: Neonatal Seizures
Interventions: DRUG: phenobarbital|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proof-of-Concept Study of MSP3-LSP Vaccine to Protect Against Malaria in Africa
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: MSP3-LSP/AlOH|BIOLOGICAL: Verorab Vaccine|OTHER: 0.9% NaCl/Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Non-Invasive Intravascular Laser Irradiation Of Blood In The Treatment Of Children With Temporomandibular Disorders
Status: NOT_YET_RECRUITING
Conditions: Temporomandibular Disorder
Interventions: RADIATION: Non-Invasive Intravascular Laser Irradiation Of Blood|RADIATION: Placebo application of laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of GentleWave System in Endodontic Treatment
Status: NOT_YET_RECRUITING
Conditions: Pain, Postoperative|Root Canal Infection|Endodontically Treated Teeth
Interventions: OTHER: GentleWave|OTHER: Conventional Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of CIS43LS Anti-malaria mAb in Mali
Status: COMPLETED
Conditions: Plasmodium Falciparum Infection|Malaria
Interventions: BIOLOGICAL: VRC-MALMAB0100-00-AB (CIS43LS)|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy in Treating Patients With Refractory or Recurrent Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: alvocidib|DRUG: cisplatin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Toripalimab Combined With Chemotherapy and Bevacizumab as First-Line Treatment in Patients With Advanced Cervical Cancer
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: DRUG: Toripalimab|DRUG: Paclitaxel|DRUG: Cisplatin|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Helicobacter Pylori Eradication Trial to Reduce Iron Deficiency in Children
Status: COMPLETED
Conditions: Iron Deficiency
Interventions: DRUG: Quadruple sequential Helicobacter pylori eradication + iron sulfate|DRUG: Quadruple sequential Helicobacter pylori eradication therapy|DRUG: Ferrous sulfate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of a Probiotic Water on Oral Health in Adults
Status: COMPLETED
Conditions: Oral Bacteria|Halitosis
Interventions: DIETARY_SUPPLEMENT: Streptococcus salivarius DB-B5 - 2 billion CFU/day|DIETARY_SUPPLEMENT: Streptococcus salivarius DB-B5 - 10 billion CFU/day|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Safety and Efficacy of Polatuzumab Vedotin in Combination With Rituximab, Gemcitabine and Oxaliplatin Compared to Rituximab, Gemcitabine and Oxaliplatin Alone in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Polatuzumab Vedotin|DRUG: Rituximab|DRUG: Gemcitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paravertebral Blocks: Pilot Study to Compare Nerve Stimulation vs. Anatomic Landmarks in Inguinal Hernia Repair
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: PROCEDURE: PVB using nerve stimulation|PROCEDURE: PVB using anatomic landmarks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Cholesterol-lowering Efficacy of Probiotic Lactobacillus Plantarum in Hypercholesterolaemic Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Lactobacillus plantarum ECGC 13110402|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: BG00010 (Neublastin) Phase 2 Multiple Dose Adaptive Design in Participants With Painful Lumbar Radiculopathy
Status: COMPLETED
Conditions: Painful Lumbar Radiculopathy|Sciatica|Radiculopathy
Interventions: DRUG: BG00010|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ketamine to Prevent PPD After Cesarean
Status: COMPLETED
Conditions: Postpartum Depression
Interventions: DRUG: Ketamine 50 MG/ML|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prospective Randomized Controlled Trial of an Enhanced Recovery Protocol for Anorectal Surgery
Status: COMPLETED
Conditions: Anorectal Disorder
Interventions: COMBINATION_PRODUCT: ERAS|COMBINATION_PRODUCT: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy of a Protocol for the Withdrawal of Neurosedation From the Usual Strategy in Cerebroses
Status: COMPLETED
Conditions: Withdrawal Syndrome|Cerebral Lesion
Interventions: OTHER: Variation of Jasinski score between H0 (stop of sedatives) and H6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Anti-VEGF Monoclonal Antibody hPV19 in Patients With Solid Tumors
Status: UNKNOWN
Conditions: Solid Tumors
Interventions: BIOLOGICAL: hPV19 mAb|BIOLOGICAL: hPV19 mAb|DRUG: 5-Fluorouracil|DRUG: Oxaliplatin|DRUG: Leucovorin|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Gemcitabine|DRUG: Carboplatin|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of a Topical Form of Nitroglycerin and Placebo in the Treatment and Prevention of Raynaud's Phenomenon
Status: UNKNOWN
Conditions: Raynaud's Disease|Raynaud's Disease Secondary to Scleroderma|Raynaud's Disease Secondary to Other Autoimmune Disease
Interventions: DRUG: Nitroglycerin|DRUG: Topical AmphiMatrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study on the Effect of Vitamin D Treatment in Patients With Statin-Associated Myalgia
Status: WITHDRAWN
Conditions: Hyperlipidemia
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of an Experimental Nasal Spray in Subjects With Early Signs of the Common Cold
Status: COMPLETED
Conditions: Common Cold
Interventions: DEVICE: Polymeric Nasal Spray|DEVICE: Sham Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Relative Bioavailability of Ruxolitinib Extended Release (XR) Tablets Compared With Ruxolitinib Immediate Release (IR) Tablets Administered Orally in Healthy Participants.
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Ruxolitinib IR|DRUG: Ruxolitinib XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Zocor (Simvastatin) and Vytorin (Ezetimibe/Simvastatin) in Adolescents With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Dyslipidemia
Interventions: DRUG: Simvastatin|DRUG: Ezetimibe/Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Florbetaben (BAY94-9172) PET Imaging for Detection/Exclusion of Cerebral β-amyloid.
Status: COMPLETED
Conditions: Down Syndrome|Amyloid Beta-protein
Interventions: DRUG: Florbetaben (BAY94-9172)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Dural Puncture Epidural Block Technique on the Effectiveness and Safety of Labor Analgesia
Status: RECRUITING
Conditions: Labor Analgesia
Interventions: DEVICE: ultrasound real-time guidance combined with Dural Puncture Epidural Labor Anagesia|DEVICE: ultrasound real-time guidance combined with Epidural Labor Anagesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of CBT- Based Weight Loss Program on Obesity
Status: COMPLETED
Conditions: Obesity|Hypercholesterolemia|Diabetes Mellitus, Type 2|Anhedonia
Interventions: BEHAVIORAL: Cognitive behavioral therapy -based weight loss program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Integra Accell Evo3 DBM in Instrumented Lumbar Spine Fusion
Status: COMPLETED
Conditions: Stenosis|Spondylosis|Degenerative Changes
Interventions: DEVICE: Accell Evo3 Prospective Use
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Periodontitis in Obese Individuals
Status: COMPLETED
Conditions: Obese|Obesity, Morbid|Periodontitis
Interventions: COMBINATION_PRODUCT: One-stage full-mouth disinfection with chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pelvic Organ Prolapse Repair With or Without Concomitant Burch Colposuspension in Patients With Urinary Incontinence
Status: COMPLETED
Conditions: Pelvic Organ Prolapse|Urinary Incontinence
Interventions: PROCEDURE: Pelvic organ prolapse repair and Burch colposuspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypoglossal Nerve Stimulation Therapy in Patients With Obstructive Sleep Apnea: Belgian Registry
Status: RECRUITING
Conditions: Obstructive Sleep Apnea|Sleep Apnea|Apnea
Interventions: DEVICE: Hypoglossal nerve stimulation Inspire system (Inspire Medical Systems Inc., USA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of AFQ056 in Reducing L-dopa Induced Dyskinesias in Parkinson's Disease Patients
Status: COMPLETED
Conditions: Parkinson's Disease|L-dopa Induced Dyskinesia
Interventions: DRUG: AFQ056|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Safety/Tolerability and Pharmacokinetics/Pharmacodynamics of CKD-519
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: CKD-519|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, PK, PD and Preliminary Efficacy of ONO-4685
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: ONO-4685|DRUG: Placebo|DRUG: ONO-4685|DRUG: Placebo|DRUG: ONO-4685|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of mHealth on Interdental Brushing in Type 2 Embrasures"
Status: RECRUITING
Conditions: Periodontitis
Interventions: BEHAVIORAL: mobile health|PROCEDURE: Scaling and root planing+Interdental aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SONOthrombolysis in Patients With an ST-segment Elevation Myocardial Infarction With fibrinoLYSIS (SONOSTEMI-LYSIS) Trial
Status: RECRUITING
Conditions: ST Elevation Myocardial Infarction
Interventions: DRUG: Definity® with High Mechanical Index Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Icodextrin Postpones the Shift of Low Dose to Full Dose Dialysis in the First Year of Incremental Peritoneal Dialysis
Status: RECRUITING
Conditions: Peritoneal Dialysis
Interventions: DRUG: Icodextrin Peritoneal Dialysis Solution|DRUG: Hypertonic Dextrose solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PLASOMA Ultimate Safety & Efficacy Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetic Foot Ulcer|Venous Leg Ulcer|Pressure Ulcer|Burn Wound|Skin Graft|Infected Surgical Wound|Skin Flap
Interventions: DEVICE: PLASOMA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GLP-1 Analogue in Preventing Progression of Small Vessel Disease (GAPP-SVD)
Status: RECRUITING
Conditions: Cerebral Small Vessel Disease
Interventions: DRUG: Exenatide extended release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine, Capecitabine, and Oxaliplatin as Second-Line Therapy in Treating Patients With Advanced Colorectal Cancer Previously Treated With Irinotecan
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: capecitabine|DRUG: gemcitabine hydrochloride|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating DNA Double-strand Breaks (DSBs) REpair Factors (POLQ, Shieldin Complex and 53BP1) Expression as Biomarker of PARP Inhibitor Resistance in Patients With Deleterious Germline Mutation in BRCA 1/2 and HER2-negative, Metastatic or Locally Advanced Breast Cancer.
Status: RECRUITING
Conditions: Breast Cancer
Interventions: OTHER: Main study:|OTHER: Sub-study:
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Transcatheter Mitral Valve InterventiOn Single Center Registry in CHinese Patients With Mitral Valve Disease (TORCH-M)
Status: RECRUITING
Conditions: Mitral Valve Disease
Interventions: DEVICE: transcatheter mitral valve repair/transcatheter mitral valve replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-finding Study of MCI-196
Status: TERMINATED
Conditions: Chronic Kidney Disease|Dialysis|Hyperphosphatemia|Paediatric
Interventions: DRUG: colestilan-L|DRUG: colestilan-M|DRUG: colestilan-H|DRUG: CBPB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 7-day Compared With 10-day Antibiotic Treatment for Febrile Urinary Tract Infections in Children
Status: UNKNOWN
Conditions: Urinary Tract Infections in Children
Interventions: OTHER: Longer therapy duration|OTHER: Shorter therapy duration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Rectus Sheath Catheter to Epidural Post Cystectomy
Status: UNKNOWN
Conditions: Bladder Cancer|Postoperative Pain
Interventions: DEVICE: Epidural|DEVICE: Rectus Sheath Catheters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimized Recovery After Trauma in Geriatric Patient
Status: RECRUITING
Conditions: Geriatric Assessment|Quality of Life|Trauma|Fragility|Injury|Rehabilitation|Recovery
Interventions: OTHER: gero-erat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Adjuvant PD-1 Antibody in Combination With Capecitabine for Patients With ICC at High-Risk of Postoperative Recurrence
Status: UNKNOWN
Conditions: Cholangiocarcinoma, Intrahepatic
Interventions: DRUG: Capecitabine|DRUG: PD-1 Antibody（Tislelizumab）
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mi-Helper Transnasal Cooling for Acute Treatment of Migraine
Status: ACTIVE_NOT_RECRUITING
Conditions: Episodic Migraine|Migraine With Aura|Migraine Without Aura|Migraine
Interventions: DEVICE: Mi-Helper
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carry Life@ UF System Clinical Study
Status: ENROLLING_BY_INVITATION
Conditions: End Stage Renal Disease
Interventions: DEVICE: Carry Life UF|DRUG: 2.27% glucose peritoneal dialysis dwell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Transcutaneous Electrical Nerve Stimulation (TENS) Application on Patients' Undergoing Hip Replacement
Status: NOT_YET_RECRUITING
Conditions: Hip Fractures|Pain, Postoperative|Analgesia
Interventions: DEVICE: TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate Fadraciclib (CYC065), in Subjects With Leukemia or Myelodysplastic Syndrome (MDS)
Status: SUSPENDED
Conditions: Leukemia|Myelodysplastic Syndrome(MDS)
Interventions: DRUG: fadraciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AZD7798 Safety, Tolerability, and Pharmacokinetics After a Single Ascending and Repeat Dose Administrations to Healthy Subjects, and Patients With Crohn's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Subjects|Crohns Disease
Interventions: BIOLOGICAL: AZD7798|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Pilot Study of Mixed Chimerism to Treat Hemoglobinopathies
Status: WITHDRAWN
Conditions: Anemia, Sickle Cell|Complex and Transfusion-dependent Hemoglobinopathies|Thalassemia|Diamond-Blackfan Anemia|Bone Marrow Failure Syndromes|Alpha-Thalassemia|Beta-Thalassemia
Interventions: BIOLOGICAL: Enriched Hematopoetic Stem Cell Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Age-related Macular Degeneration Using Retinal Stem and Progenitor Cells
Status: UNKNOWN
Conditions: Age-Related Macular Degeneration
Interventions: BIOLOGICAL: Cultured retinal stem and progenitor cells|OTHER: Standard treatment according to the clinical protocols
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bovine Lactoferrin and Antibiotic-associated Diarrhoea.
Status: COMPLETED
Conditions: Antibiotic Associated Diarrhoea
Interventions: DIETARY_SUPPLEMENT: Bovine lactoferrin|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Preemptive Analgesia for Post Tonsillectomy Pain With IV Morphine in Children
Status: UNKNOWN
Conditions: Preoperative Sedation|Postoperative Pain
Interventions: DRUG: Morphine premedication|DRUG: Midazolam premedication|DRUG: Saline premedication (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of CS1001 in Subjects With Stage IV Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: CS1001 monoclonal antibody|BIOLOGICAL: CS1001 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Ibuprofen l-Lysine Solution in Premature Infants for Treatment of PDA
Status: COMPLETED
Conditions: Patent Ductus Arteriosus
Interventions: DRUG: ibuprofen l-lysine iv solution (NeoProfen (R) )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Gluteal Muscle Atrophy: A Silent Predictor of THA Dislocation.
Status: COMPLETED
Conditions: Dislocation|Total Hip Arthroplasty|Muscle Degeneration
Interventions: DIAGNOSTIC_TEST: Dislocation|DIAGNOSTIC_TEST: No dislocation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Varenicline Treatment for Smoking Cessation in Patients With Bipolar Disorder
Status: COMPLETED
Conditions: Smoking Cessation|Bipolar Disorder
Interventions: DRUG: Varenicline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability and Pharmacokinetics of ASP3700 in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Volunteers|Pharmacokinetics of ASP3700
Interventions: DRUG: ASP3700|DRUG: itraconazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Two Part Trial Investigating NN1952 in Healthy Subjects and Subjects With Type 1 and Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2|Healthy
Interventions: DRUG: NN1952|DRUG: insulin aspart|DRUG: placebo|DRUG: NN1952|DRUG: insulin aspart|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of CAR-iNKT Cells in the Treatment of Relapsed/Refractory/High-risk B-cell Tumors
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia|B-cell Lymphoma|Chronic Lymphocytic Leukemia
Interventions: DRUG: hCD19.IL15.CAR-iNKT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D3 Supplementation on Arterial and Bone Remodeling in Chronic Kidney Disease Patients
Status: COMPLETED
Conditions: Renal Insufficiency, Chronic|Vascular Stiffness|Bone Diseases, Metabolic
Interventions: DRUG: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (LOGOS)
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: BGF MDI 320/28.8/9.6 μg|DRUG: BGF MDI 320/14.4/9.6 μg|DRUG: BFF MDI 320/9.6 μg|DRUG: BFF pMDI 320/9 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Concurrent and Non-concurrent Chemo-radiotherapy or Radiotherapy Alone With Intensity-modulated Radiotherapy (IMRT) for Non Small Cell Lung Cancer (NSCLC) to an Individualised Mean Lung Dose (MLD)
Status: COMPLETED
Conditions: Stage I-III Non-small Cell Lung Cancer
Interventions: RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Techniques of IV Lidocaine on Propofol Injection Pain
Status: COMPLETED
Conditions: Injections, Intravenous
Interventions: DRUG: Lidocaine injection flushed|DRUG: Lidocaine injection tourniquet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation
Status: UNKNOWN
Conditions: ARDS|Intra-abdominal Hypertension
Interventions: DEVICE: titrated setting peep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aesthetic Outcomes of Oncoplastic Breast Surgery for Breast Cancer in the Upper Inner Quadrant
Status: UNKNOWN
Conditions: Oncoplastic Breast Surgery|Breast Cancer|Aesthetic Outcomes
Interventions: PROCEDURE: Oncoplastic technique with a droplet-shaped glandular flap
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Islatravir (MK-8591) in Anti-Retroviral Therapy-Naive, Human Immunodeficiency Virus-1 Infected Participants (MK-8591-003)
Status: COMPLETED
Conditions: HIV-1
Interventions: DRUG: 1 mg islatravir|DRUG: 2 mg islatravir|DRUG: 10 mg islatravir|DRUG: 30 mg islatravir|DRUG: 0.5 mg islatravir|DRUG: 0.25 mg islatravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Light, Ion, and Fluoxetine Efficacy (LIFE) in Depression
Status: COMPLETED
Conditions: Major Depressive Disorder (MDD)
Interventions: PROCEDURE: Light treatment|PROCEDURE: Negative ion therapy|DRUG: Placebo|DRUG: Fluoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Regular Antibacterial Photodynamic Therapy on Oral Hygiene in the Elderly 24-hour Care
Status: WITHDRAWN
Conditions: Inflamed Gums|Dryness Oral|Plaque
Interventions: DEVICE: Lumoral Treatment|OTHER: Standard oral hygiene instructions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study Between Intrathecal Dexmedetomidine VS Ketamine With Intrathecal Bupivacaine in Orthopedic Lower Limb Surgeries.
Status: NOT_YET_RECRUITING
Conditions: Bone Fracture
Interventions: DRUG: Dexmedetomidine|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Temporalis and Masseter Botox Injection Before Orthognathic Surgery to Improve Postoperative Pain
Status: NOT_YET_RECRUITING
Conditions: Pain, Postoperative
Interventions: DRUG: Botox 100 UNT Injection|OTHER: 0.9% Saline Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Balance After Knee Arthroplasty
Status: RECRUITING
Conditions: Postural Balance|Knee Arthroplasty|Quality of Life
Interventions: PROCEDURE: Knee Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Acupressure Applied to the Primiparous During Episiotomy
Status: COMPLETED
Conditions: Episiotomy Wound|Pain|Anxiety
Interventions: BEHAVIORAL: ACUPRESSURE APPLI ACUPRESSURE APPLICATION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cap Assisted Balloon Enteroscopy Versus Conventional Balloon Enteroscopy In The Evaluation Of Obscure Gastrointestinal Bleeding: A Randomized Controlled Trial
Status: TERMINATED
Conditions: Obscure Gastrointestinal Bleeding
Interventions: PROCEDURE: CAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Ursodiol in Treating Patients With Barrett Esophagus and Low-Grade Dysplasia
Status: COMPLETED
Conditions: Barrett Esophagus|Esophageal Carcinoma
Interventions: DRUG: Ursodiol|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparing Effects of Various Combinations of 6 Hertz(Hz) rTMS & LFrTMS on Motor Recovery Due to Cerebrovascular Disease
Status: UNKNOWN
Conditions: Cerebrovascular Disease
Interventions: DEVICE: real LFrTMS at unaffected M1|DEVICE: real primed LFrTMS at unaffected M1|DEVICE: combined rTMS at both M1|DEVICE: all sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Isoniazid Prophylaxis With Concomitant Cotrimoxazole in HIV-infected Children
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: Isoniazid|DRUG: Cotrimoxazole|DRUG: isoniazid|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in Utero
Status: COMPLETED
Conditions: Microcephaly|Mental Retardation
Interventions: OTHER: Symptomatic pregnant women with positive RT-PCR ZIKV in serum or urine, or a positive serologic test specific for ZIKV
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of Flecainide to Lower the Patent Foramen Ovale Closure Risk of Atrial Arrhythmia or Tachycardia
Status: ACTIVE_NOT_RECRUITING
Conditions: Patent Foramen Ovale|Atrial Arrhythmia|Cryptogenic Stroke
Interventions: DRUG: Flecainide|DRUG: Flecainide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quadruple Fortified Salt Trial in India
Status: ACTIVE_NOT_RECRUITING
Conditions: Anemia|Folate Deficiency|Vitamin B 12 Deficiency
Interventions: OTHER: + Folic acid|OTHER: + Vitamin B12|OTHER: DFS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Feasibility of VR for Pediatric Renal Biopsies
Status: RECRUITING
Conditions: Pain, Procedural|Procedural Anxiety|Sedation Complication
Interventions: DEVICE: Samsung Gear Virtual Reality Headset
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ravulizumab in Thrombotic Microangiopathy Associated With a Trigger
Status: TERMINATED
Conditions: Thrombotic Microangiopathy
Interventions: BIOLOGICAL: Ravulizumab|OTHER: Placebo|OTHER: Best Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Augmented Infant Resuscitator to Enhance Newborn Ventilation
Status: COMPLETED
Conditions: Asphyxia Neonatorum|Birth Asphyxia|Perinatal Asphyxia
Interventions: DEVICE: Augmented Infant Resuscitator (AIR)|DEVICE: AIR device without feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical and Therapeutic Characteristics of Geriatric Patients Hospitalized for Heart Failure (AGING HF Study (AGe and Heart Failure IN Geriatrics))
Status: NOT_YET_RECRUITING
Conditions: Patients Hospitalized in Geriatrics for Heart Failure|Patients Aged 75 and Over
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Optimal Treatment for Avulsion Fractures of the Base of Fith Metatarsal Bone
Status: COMPLETED
Conditions: Closed Fracture of Base of Fifth Metatarsal Bone
Interventions: DEVICE: Compressive bandage|DEVICE: Below knee walking cast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: THE ALIGN-AR EFS TRIAL: JenaValve Pericardial TAVR Aortic Regurgitation Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Regurgitation
Interventions: DEVICE: JenaValve Pericardial TAVR System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hepatic Impairment and Renal Impairment Study of SIM0417 Combined With Ritonavir
Status: NOT_YET_RECRUITING
Conditions: Renal Impairment|Hepatic Impairment
Interventions: DRUG: SIM0417 600 mg; Ritonavir100 mg|DRUG: SIM0417 375 mg; Ritonavir100 mg|DRUG: SIM0417 750 mg; Ritonavir100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement
Status: RECRUITING
Conditions: Pulmonary Embolism|Venous Thrombosis
Interventions: DRUG: Enteric Coated Aspirin|DRUG: Warfarin|DRUG: Rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Silver Diamine Fluoride for Caries Prevention in Removable Partial Dentures Wearers
Status: UNKNOWN
Conditions: Dental Caries|Dental Caries of Root Surface
Interventions: DRUG: Silver Diamine Fluoride|DRUG: Distilled Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ETHAN - ET for Male BC
Status: RECRUITING
Conditions: Male Breast Cancer|Hormone Receptor-positive Breast Cancer|Hormone Receptor Negative Breast Carcinoma
Interventions: DRUG: Tamoxifen|DRUG: Anastrozole|DRUG: Degarelix|DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PROcalcitonin to SHORTen Antibiotics Duration in PEDiatricICU Patients (ProShort-Ped) Trial
Status: UNKNOWN
Conditions: Sepsis
Interventions: BEHAVIORAL: Procalcitonin-guided treatment|BEHAVIORAL: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Movement Assessment for Concussion Management
Status: COMPLETED
Conditions: Healthy Athlete
Interventions: OTHER: Immediate Post-concussion Assessment and Cognitive Testing|OTHER: Gait with single and dual task|OTHER: Y-Balance test|OTHER: Psychomotor Vigilance Task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Pressure and Flow Study Before and After Treatments for EMD. The pFlow Study
Status: UNKNOWN
Conditions: Esophageal Motility Disorders|Gastro-esophageal Reflux
Interventions: PROCEDURE: Peroral endoscopic myotomy|PROCEDURE: Neumatic dilatation|PROCEDURE: Botulinum toxin injection|PROCEDURE: Laparoscopic Heller Myotomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Non Promyelocytic Acute Myeloid Leukaemia on Elderly Patients by Low Dose Cytosar Plus Arsenic Trioxide
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: Cytosar|DRUG: Arsenic trioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions
Status: COMPLETED
Conditions: Cancer
Interventions: BIOLOGICAL: recombinant adenovirus-hIFN-beta
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: PROMOTE Study: Prediction of Response Of HorMOnal Treatment in Advanced and Recurrent Endometrial Cancer
Status: RECRUITING
Conditions: Endometrial Cancer Stage III|Endometrial Cancer Stage IV|Endometrial Cancer Recurrent
Interventions: DRUG: Hormonal Antineoplastics
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Upper Limb Spinal Cord Stimulation for Rehabilitation Enhancement
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: OTHER: Transcutaneous spinal cord stimulation added to inpatient rehabilitation|OTHER: Inpatient rehabilitation alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypothermia Prevention in Low Birthweight and Preterm Infants
Status: UNKNOWN
Conditions: Neonatal Hypothermia
Interventions: OTHER: Kangaroo Mother Care and BEMPU bracelet|OTHER: Kangaroo Mother Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prevention of Post-Mastectomy Breast Pain Using Ambulatory Continuous Paravertebral Blocks
Status: COMPLETED
Conditions: Paravertebral Catheter Insertion|Mastectomy|Breast Cancer
Interventions: PROCEDURE: Placebo (normal saline) Continuous Infusion|PROCEDURE: Ropivicaine 0.4% Continuous Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Imatinib on Suppression of Malaria Parasites in Patients With Uncomplicated Plasmodium Falciparum Malaria
Status: COMPLETED
Conditions: Plasmodium Falciparum Malaria
Interventions: DRUG: Imatinib combination therapy|DRUG: Dihydroartemisinin-piperaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetic and Environmental Factors in the Response to Influenza Vaccination
Status: COMPLETED
Conditions: Influenza|Healthy
Interventions: BIOLOGICAL: FluMist® Quadrivalent|BIOLOGICAL: Fluzone® Quadrivalent vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Percutaneous Cryoablation of Intercostal Nerves for the Treatment of Rib Fractures
Status: ENROLLING_BY_INVITATION
Conditions: Trauma|Rib Fractures|Chest Wall Disorder|Respiratory Insufficiency|Pain, Chest|Rib Trauma|Rib Fracture Multiple|Respiratory Failure|Respiratory Distress Syndrome
Interventions: DEVICE: Percutaneous Cryoablation of Intercostal Nerves|OTHER: Multi-modal pain regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dysport® Adult Lower Limb Spasticity Study
Status: COMPLETED
Conditions: Leg Spasticity
Interventions: BIOLOGICAL: Botulinum toxin type A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of the Inclination Angle and Complications of Eccentric Grafts Position in ACL Reconstruction and Normal ACL: Retrospective Cohort
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injuries
Interventions: PROCEDURE: Interference screw
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Islet After Kidney Transplantation (IAK) in Patients With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: PROCEDURE: Islet Transplantation|BIOLOGICAL: Islet cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Voluven on Hemodynamics and Tolerability of Enteral Nutrition in Patients With Severe Sepsis
Status: COMPLETED
Conditions: Sepsis
Interventions: DRUG: 6 % Hydroxyethylstarch 130/0.4 = "Voluven®"|DRUG: 0.9 % NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BIO4 Clinical Case Study: Cervical Spine
Status: COMPLETED
Conditions: Degenerative Disc Disease|Trauma (Including Fractures)|Spondylolisthesis
Interventions: BIOLOGICAL: 1 or 2-Level ACDF utilizing BIO4 with Bio AVS Cervical Allograft (with graft window).|DEVICE: Aviator Anterior Cervical Plating System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ecco2R to facilitatE earLy libEration From mechanicAl Ventilation inpatientS With Copd Acute Exacerbation
Status: UNKNOWN
Conditions: Acute Exacerbation of COPD
Interventions: DEVICE: Low flow ECCO2R|DEVICE: Invasive mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Peritoneal Carcinomatosis From Ovarian Cancer (Cyto-chip 2)
Status: COMPLETED
Conditions: Peritoneal Carcinoma|Ovarian Cancer
Interventions: PROCEDURE: Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy procedure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p