pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of the Safety and Effectiveness of DIAM™ Spinal Stabilization System Versus Conservative Care
Status: TERMINATED
Conditions: Lumbar Degenerative Disc Disease
Interventions: DEVICE: DIAM™ Spinal Stabilization System|PROCEDURE: Conservative care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Navigated Repetitive Transcranial Magnetic Stimulation for Parkinson's Disease With Depression or Cognitive Impairment
Status: UNKNOWN
Conditions: Parkinson Disease|Depression|Cognitive Impairment
Interventions: DEVICE: repetitive transcranial magnetic stimulation(rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: tDCS and rTMS in Patients With Early Disorders of Consciousness
Status: NOT_YET_RECRUITING
Conditions: Disorder of Consciousness|Stroke|Ischemic-hypoxic Encephalopathy
Interventions: DEVICE: tDCS|DEVICE: rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Zazen Meditation in Patients With Acute Myocardial Infarction - Randomized Clinical Trial
Status: RECRUITING
Conditions: Heart Rate Variability|Acute Myocardial Infarction
Interventions: BEHAVIORAL: Zazen Meditation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effectiveness of Modafinil for Treating Fatigue in Adults With HIV/AIDS
Status: COMPLETED
Conditions: HIV Infections|Fatigue
Interventions: DRUG: Modafinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Body Warming in Improving Blood Flow and Oxygen Delivery to Tumors in Patients With Cancer
Status: COMPLETED
Conditions: Adult Liver Carcinoma|Breast Carcinoma|Colon Carcinoma|Kidney Neoplasm|Lung Carcinoma|Malignant Head and Neck Neoplasm|Malignant Neoplasm|Melanoma|Ovarian Neoplasm|Soft Tissue Sarcoma
Interventions: PROCEDURE: Hyperthermia Treatment|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Coupling Repetitive Transcranial Magnetic Stimulation With a Neuronavigation System in Treatment Resistant Depression
Status: COMPLETED
Conditions: Treatment Resistant Depression
Interventions: DEVICE: Neuronavigation system|DEVICE: Standard localisation method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of a Novel Insulin Lispro Formulation in Participants With Type 1 Diabetes Mellitus Using Insulin Pumps
Status: WITHDRAWN
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Insulin Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tramadol Versus Placebo in the Management of Postoperative Pain Following Bunionectomy
Status: COMPLETED
Conditions: Pain Management
Interventions: DRUG: Tramadol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Apatinib Plus Docetaxel as 2nd Line Treatment in Patients With Advanced Non-squamous and Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Apatinib|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Stapler Reinforcement Patches Compared to Standard Staplers in Gastrojejunostomy
Status: RECRUITING
Conditions: Gastric Cancer|Gastrostomy|Anastomotic Leakage|Postoperative Complications
Interventions: DEVICE: Stapler Reinforcement Patch|DEVICE: Standard Stapler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of OMP-54F28 in Combination With Nab-Paclitaxel and Gemcitabine in Patients With Previously Untreated Stage IV Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer|Stage IV Pancreatic Cancer
Interventions: DRUG: OMP-54F28, Nab-Paclitaxel and Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD19/CD22 Bispecific CAR-T Cell Therapy for Relapsed/Refractory B-cell Lymphoma or Acute Lymphoblastic Leukemia
Status: RECRUITING
Conditions: B-cell Acute Lymphoblastic Leukemia|B-cell Lymphoma|Diffuse Large B Cell Lymphoma
Interventions: DRUG: CD19/CD22-bispecific CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3D Printed Custom Applicators for HDR BT (DISCO)
Status: RECRUITING
Conditions: Gynecologic Cancer|Endometrial Cancer|Vaginal Cancer|Vulva Cancer
Interventions: DEVICE: 3D-printed custom applicator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Stroke Disease Management - Stroke Card
Status: COMPLETED
Conditions: Stroke|Ischemic Attack, Transient|Secondary Prevention|Disease Management|Cost-Benefit Analysis
Interventions: BEHAVIORAL: Active Comparator: Extended Standard Care (Stroke Card)|BEHAVIORAL: Active Comparator: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating How the Treatments in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study Affect Diabetic Retinopathy (The ACCORD Eye Study)
Status: COMPLETED
Conditions: Diabetic Retinopathy
Interventions: DRUG: Hypoglycemic Agents|DRUG: Standard glycemia control|DRUG: Intensive BP treatment|DRUG: Standard BP control|DRUG: Fenofibrate|DRUG: Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Manual Therapy as a Form of Sensory Discrimination in Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: PROCEDURE: Neuroplasticity Explanation (Experimental)|PROCEDURE: Biomechanical Explanation (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Aromatase Inhibitor Effects on Ovarian Function During the Follicular and Early Luteal Phase in Women
Status: COMPLETED
Conditions: Fertility
Interventions: DRUG: Letrozole|DRUG: Letrozole|DRUG: Letrozole|DRUG: Letrozole|DRUG: Letrozole|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Triple III Comparison of Leflunomide Alone Versus Two DMARD Combinations in the Treatment of Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Leflunomide|DRUG: Methotrexate-Sulfasalazine-Hydroxychloroquine|DRUG: Leflunomide-Sulfasalazine-Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Durvalumab and BVAC-C in Patients With HPV 16 or 18 Positive Cervical Cancer Failure to First-Line Platinum-based Chemotherapy
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: BIOLOGICAL: BAVC-C+Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stimulating Brain Waves During Deep Sleep
Status: RECRUITING
Conditions: Placebo|Experimental
Interventions: DEVICE: DREEM2|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Tolerability of Oral Clofarabine in Intermediate to High Risk Myelodysplastic Patients
Status: TERMINATED
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: Clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Dose Escalation Study of Erlotinib in Combination With Theophylline
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer|Advanced Solid Malignancies
Interventions: DRUG: Theophylline|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Comparison of the Endeavor and the Cypher Coronary Stents in Non-selected Angina Pectoris Patients
Status: COMPLETED
Conditions: Ischemic Heart Disease
Interventions: DEVICE: Endeavor|DEVICE: Cypher Select
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of Two Reusable Silicone Hydrogel Contact Lenses
Status: COMPLETED
Conditions: Refractive Errors
Interventions: DEVICE: Serafilcon A contact lenses|DEVICE: Senofilcon A contact lenses|DEVICE: CLEAR CARE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in First Line Treatment of Advanced NSCLC Patients With PD-L1 Low Tumors.
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACTIV-3: Therapeutics for Inpatients With COVID-19
Status: COMPLETED
Conditions: Covid19
Interventions: BIOLOGICAL: LY3819253|DRUG: Placebo|BIOLOGICAL: Remdesivir|BIOLOGICAL: VIR-7831|BIOLOGICAL: BRII-196/BRII-198|BIOLOGICAL: AZD7442|DRUG: MP0420|DRUG: PF-07304814
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Predictive Biomarkers of Response to Sunitinib in the Treatment of Poorly-differentiated NEURO-Endocrine Tumors
Status: TERMINATED
Conditions: Neuroendocrine Tumors|Pancreatic Neoplasms|Advanced Disease|Sunitinib
Interventions: DRUG: Sutent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in Locally Advanced Squamous Cell Carcinoma of Head and Neck
Status: TERMINATED
Conditions: Head and Neck Cancer
Interventions: DRUG: Everolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimisation of Response for Organ Preservation in Rectal Cancer : Neoadjuvant Chemotherapy and Radiochemotherapy vs. Radiochemotherapy
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DRUG: Neoadjuvant chemotherapy Folfirinox, 4 cycles|RADIATION: 50 Gy, 2 Gy/session; 25 fractions|PROCEDURE: Local excision in good responders|PROCEDURE: Rectal excision in bad responders|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cardio-respiratory Events and Inflammatory Response After Primary Immunization in Preterm Infants
Status: COMPLETED
Conditions: Complication Due to Immunization
Interventions: DRUG: Advil® Pediatric drops for infants|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Bihormonal iLet Bionic Pancreas Feasibility Study
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Bihormonal iLet Bionic Pancreas|DEVICE: Insulin-only Bionic Pancreas|DRUG: Dasiglucagon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ruxolitinib and Pracinostat Combination Therapy for Patients With Myelofibrosis (MF)
Status: COMPLETED
Conditions: Myeloproliferative Diseases
Interventions: DRUG: Ruxolitinib|DRUG: Pracinostat|BEHAVIORAL: Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Vitreosolve® for Non-Proliferative Diabetic Retinopathy Subjects
Status: UNKNOWN
Conditions: Diabetic Retinopathy
Interventions: DRUG: Vitreosolve|DRUG: Vitreosolve
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Gender Differences in Response to Nicotine Replacement Therapy and De-Nicotinized Cigarettes
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: DRUG: nicotine patch (Nicoderm Committed Quitter (CQ), Habitrol)|OTHER: denicotinized cigarettes (Quest 3 cigarettes)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Schemas, Cognitive Emotion Regulation on Quality of Life of HIV Patients: Assessing Outcomes of CBT
Status: COMPLETED
Conditions: Quality of Life
Interventions: BEHAVIORAL: CaCBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of LY2541546 in Healthy Postmenopausal Women
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY2541546 - IV|DRUG: LY2541546 - SC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Naltrexone and Hypoglycemia in Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes|Hypoglycemia Unawareness
Interventions: DRUG: Naltrexone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cholesterol and Antioxidant Treatment in Patients With Smith-Lemli-Opitz Syndrome (SLOS)
Status: RECRUITING
Conditions: Smith-Lemli-Opitz Syndrome|Cone-Rod Dystrophy|Hearing Loss
Interventions: DRUG: Antioxidants|DRUG: Cholesterol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azathioprine Versus Placebo in Pemphigus Vulgaris Treated With Prednisolone
Status: COMPLETED
Conditions: Pemphigus Vulgaris
Interventions: DRUG: Azathioprine|DRUG: Prednisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Ergonomics Training and Exercise in Esports Players
Status: COMPLETED
Conditions: Musculoskeletal Diseases|Musculoskeletal Pain
Interventions: OTHER: ergonomics training|OTHER: Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of MEOPA + Paracetamol Versus Morphine Treatment in Acute Coronary Syndrome Analgesia.
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: MEOPA and paracetamol|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medications for Obstructive Sleep Apnea In Children With Down Syndrome
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Down Syndrome
Interventions: DRUG: Atomoxetine and oxybutynin (ato-oxy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sugammadex on Remifentanil Ce for Preventing Emergence Cough in Female
Status: COMPLETED
Conditions: Gallbladder Diseases
Interventions: DRUG: Sugammadex Injectable Product|DRUG: Neostigmine Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Headgear Accessory for Exercise-Induced Laryngeal Obstruction Studies
Status: RECRUITING
Conditions: Exercise-Induced Laryngeal Obstruction
Interventions: DEVICE: Continuous laryngoscopy during exercise test using the HALOS headgear
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy Study of Additional Chemotherapy After Concurrent Chemoradiation in Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: consolidation chemotherapy with Docetaxel plus cisplatin|DRUG: CCRT arm without consolidation chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Naloxegol on Refractory Constipation in the Intensive Care Unit
Status: WITHDRAWN
Conditions: Constipation|Critical Illness
Interventions: DRUG: Polyethylene glycol|DRUG: naloxegol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase IIIB Open-Label, Comparative Study to Evaluate Saquinavir Soft Gel Capsule (SGC) Treatment in Combination With Other Antiretrovirals in HIV-1 Infected Antiretroviral-Naive Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Ritonavir|DRUG: Nelfinavir mesylate|DRUG: Saquinavir|DRUG: Delavirdine mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Mini-Dose Glucagon to Treat Non-Severe Hypoglycemia
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: G-Pen Mini™ (glucagon injection)|OTHER: Glucose Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Supraclavicular and Costoclavicular Brachial Plexus Blocks in Pediatrics
Status: COMPLETED
Conditions: Anesthesia, Local|Postoperative Pain
Interventions: DRUG: Bupivacaine 0.25% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Pediatric Solid Tumor|Germ Cell Tumor|Retinoblastoma|Hepatoblastoma|Wilms Tumor|Rhabdoid Tumor|Carcinoma|Osteosarcoma|Ewing Sarcoma|Rhabdomyosarcoma|Synovial Sarcoma|Clear Cell Sarcoma|Malignant Peripheral Nerve Sheath Tumors|Desmoplastic Small Round Cell Tumor|Soft Tissue Sarcoma|Neuroblastoma|Melanoma
Interventions: BIOLOGICAL: second generation 4-1BBζ B7H3-EGFRt-DHFR|BIOLOGICAL: second generation 4-1BBζ B7H3-EGFRt-DHFR(selected) and a second generation 4-1BBζ CD19-Her2tG|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of LXS196 in Patients With Metastatic Uveal Melanoma.
Status: TERMINATED
Conditions: Uveal Melanoma
Interventions: DRUG: LXS196|DRUG: LXS196 and HDM201
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Infliximab to Treat Crohn'S-like Inflammatory Bowel Disease in Chronic Granulomatous Disease
Status: TERMINATED
Conditions: Chronic Granulomatous Disease|Crohn'S-like IBD|Inflammatory Bowel Disease (IBD)
Interventions: DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-dose S-Ketamine and Postpartum Depression in Parturients With Prenatal Depression
Status: COMPLETED
Conditions: Prenatal Depression|Ketamine|Postpartum Depression
Interventions: DRUG: S-ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Aprepitant Without Steroid in Preventing Chemotherapy-induced Nausea and Vomiting in Patients With Colorectal Cancer
Status: COMPLETED
Conditions: Chemotherapy-induced Nausea and Vomiting|Colorectal Cancer
Interventions: DRUG: Aprepitant+Tropisetron|DRUG: Dexamethasone+Tropisetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Zoledronic Acid in MS-patients With Osteoporosis
Status: TERMINATED
Conditions: Osteoporosis|Multiple Sclerosis
Interventions: DRUG: Zoledronic Acid|DRUG: Placebo|DIETARY_SUPPLEMENT: Calcium and Vitamin D combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of Injectable Risperidone in the Prevention of Bipolar Mood Episodes
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Risperdal Consta|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy, Safety and Pharmacokinetics of Indacaterol Acetate in Patients With Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: indacaterol|DRUG: placebo|DRUG: mometasone furoate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers of Acute Stroke in Clinic
Status: RECRUITING
Conditions: Ischemic Stroke|Ischemia|Atrial Fibrillation|Transient Ischemic Attack|Transient Cerebrovascular Events|Thrombotic Stroke|Stroke|Stroke, Acute|Stroke, Ischemic|Stroke, Complication|Stroke of Basilar Artery|Atherosclerosis|Atheroma|Cardioembolic Stroke|Cardiomyopathies|Cardiovascular Stroke|Thromboembolism
Interventions: DIAGNOSTIC_TEST: ISCDX blood test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluate Tolerability and Safety of HY209 in Healthy Volunteers
Status: ENROLLING_BY_INVITATION
Conditions: Dementia
Interventions: DRUG: HY-209|DRUG: HY-209 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluating the Efficacy and Safety of Dehypotin® in the Patients With Type 2 Diabetes Mellitus or Cardiovascular Disease
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus|Cardiovascular Disease|Hypercholesterolemia
Interventions: DRUG: Placebo|DRUG: Dehypotin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Reduced-carbohydrate Diet High in Monounsaturated Fats in Type 2 Diabetes
Status: COMPLETED
Conditions: Type2 Diabetes|Nonalcoholic Steatohepatitis|Non-Alcoholic Fatty Liver Disease|Atherosclerosis|Dyslipidemias
Interventions: DIETARY_SUPPLEMENT: Low carbohydrate diet high in monounsaturated fats
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cisplatin Induction With Paclitaxel Consolidation for Stage III-IV Epithelial Ovarian and Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer|Primary Peritoneal Cancer
Interventions: DRUG: Topotecan|DRUG: Cisplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deprescription of Gabapentinoids in Medical Inpatients
Status: COMPLETED
Conditions: Polypharmacy|Gabapentin|Pregabalin
Interventions: OTHER: In-Hopsital Patient Educational Brochure|OTHER: Physician Education about Gabapentinoid Prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized Study Comparing CMF and Goserelin + Tamoxifen in Premenopausal Receptor-positive Patients
Status: COMPLETED
Conditions: Early-stage Breast Cancer
Interventions: DRUG: Cyclophosphamide|DRUG: Methotrexate|DRUG: Fluorouracil implant|DRUG: Goserelin|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega (n)-3 PUFA Enriched Beef & Health Outcomes.
Status: COMPLETED
Conditions: CVD|Cholesterol; Metabolic Disorder|Inflammation
Interventions: DIETARY_SUPPLEMENT: Three portions per week (690g beef (raw weight)) for 5 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Evaluation of Gabapentine and Occlusal Splint in the Management of Sleep Bruxism
Status: COMPLETED
Conditions: Sleep Bruxism
Interventions: DEVICE: occlusal stabilization splint|DRUG: Gabapentine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Two Doses of SP-8203 in Patients With Ischemic Stroke Requiring rtPA
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: SP-8203 High dose|DRUG: SP-8203 Low dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Wearable Pulsed Electromagnetic Fields Device in Knee Osteoarthritis: Double Blinded, Randomized Clinical Trial
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Wearable pulsed electromagnetic fields
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Normal Saline Infusion for Stroke After Intravenous Thrombolysis
Status: RECRUITING
Conditions: Brain Infarct
Interventions: DRUG: 0.9% NaCl 2000ml|DRUG: 0.9% NaCl 0ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Breast Cancer Shrinkage Modes After Neoadjuvant Chemotherapy With Whole-mount Serial Sections and Three-dimensional Pathological and MRI Reconstruction
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DEVICE: Ultrasound|PROCEDURE: CNB|PROCEDURE: BCS, Modified Radical Mastectomy|DEVICE: Pathologic Large Tissue Selected Table|DEVICE: Leica TP1020|DEVICE: Pathologic Large Tissue Embedded Table|DEVICE: Leica SM2000 R|PROCEDURE: HE Stain|DEVICE: CX22|DEVICE: Epson V600|DEVICE: MRI|PROCEDURE: Three-Dimensional Reconstruction|DEVICE: Mammography|DRUG: TAC,TC,TA,CAF,CEF|DRUG: AC-P,TEC,AC,TC,TCH,CEF,TAC,CAF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacological and Behavioral Treatment After Bariatric Surgery: Acute (Stage 1)
Status: RECRUITING
Conditions: Loss-of-control Eating|Obesity/Overweight
Interventions: DRUG: Naltrexone and Bupropion medication|BEHAVIORAL: Behavioral Weight Loss|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Conventional Versus IMRT Whole Brain Radiotherapy for Brain Metastases
Status: UNKNOWN
Conditions: Metastatic Brain Cancer
Interventions: RADIATION: Whole Brain IMRT|RADIATION: Conventional Whole Brain RT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Nitazoxanide and Escitalopram in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Placebo|DRUG: Nitazoxanide 500Mg Oral Tablet|DRUG: Escitalopram 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastric Emptying Study After Administration of a High Caloric Sip Feed
Status: COMPLETED
Conditions: Enteral Nutrition
Interventions: DIETARY_SUPPLEMENT: ProvideXtra DRINK (oral nutritional supplement, food for special medical purposes)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: EXCEL-II Stent Vesus EXCEL Stent to Treat the Patients With de Novo Coronary Artery Lesions.
Status: COMPLETED
Conditions: Coronary Artery Disease|Myocardial Ischemia|Coronary Disease|Heart Diseases|Cardiovascular Diseases|Arteriosclerosis|Arterial Occlusive Diseases|Vascular Diseases
Interventions: PROCEDURE: EXCEL DES implatation|PROCEDURE: EXCEL-II DES implantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety, PK, PD and Food Effect Study of URC102 in Healthy Adults and Patients With Renal Impairment
Status: COMPLETED
Conditions: Healthy, Renal Impairment
Interventions: DRUG: URC102|DRUG: URC102
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polymyxin B Monotherapy vs Combination Therapy in Critically Ill Patients With Multi-drug Resistant Pathogens
Status: UNKNOWN
Conditions: Trauma|Resistant Infection|Critical Illness
Interventions: DRUG: Polymyxin B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Saccharomyces boulardii|DRUG: Methyl cellulose powder (low viscosity)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Look at the Effect MEDI0382 Has on Blood Sugar in People With Type 2 Diabetes and Kidney Problems and Also to Check That MEDI0382 is Well Tolerated
Status: COMPLETED
Conditions: Type II Diabetes Mellitus|Renal Insufficiency
Interventions: DRUG: MEDI0382|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Two Strategies for Debriefing in the Development of Skills for Neonatal Resuscitation
Status: COMPLETED
Conditions: Asphyxia Neonatorum|Birth Injuries|Cardiopulmonary Resuscitation
Interventions: OTHER: Structured debriefing assisted by video|OTHER: Structured oral debriefing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: G-PUR® for Reduced Dietary Fumonisin Bioavailability
Status: TERMINATED
Conditions: Reduction of Dietary Fumonisin Bioavailability
Interventions: DEVICE: 2.0g G-PUR®|DEVICE: 2.0g G-PUR®|OTHER: Placebo|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Triage of Patients With Acute Ischemic Stroke Due to Large Vessel Occlusions-1 (TRACK-LVO-1)
Status: ENROLLING_BY_INVITATION
Conditions: Stroke, Acute Ischemic|Endovascular Procedures|Large Vessel Occlusion
Interventions: PROCEDURE: Endovascular Therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial
Status: COMPLETED
Conditions: Shock, Septic|Critically Ill|Vasoplegic Syndrome|Sepsis
Interventions: DRUG: Vitamin C|DRUG: Thiamine|DRUG: Hydrocortisone,
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Course Radiotherapy Combined With Chemotherapy in Stage IV Rectal Cancer With Resectable Liver Metastases
Status: UNKNOWN
Conditions: Stage IV Rectal Cancer, Liver Metastasis, Resectable
Interventions: RADIATION: Short course radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Human Chorionic Gonadotropin in Preventing Breast Cancer in Premenopausal Women With BRCA1 Mutations
Status: TERMINATED
Conditions: BRCA1 Mutation|Breast Cancer
Interventions: BIOLOGICAL: recombinant human chorionic gonadotropin|GENETIC: microarray analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|PROCEDURE: needle biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Nilotinib on Safety, Tolerability, Pharmacokinetics and Biomarkers in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease|Parkinsons Disease With Dementia
Interventions: DRUG: Placebo Oral Capsule|DRUG: Nilotinib 150mg oral capsule [Tasigna]|DRUG: Nilotinib 300mg oral capsule [Tasigna]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blood Levels of Anti-HIV Drugs Used in Combination Regimens in HIV Infected Children
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Atazanavir|DRUG: Darunavir|DRUG: Efavirenz|DRUG: Nevirapine|DRUG: Ritonavir|DRUG: Tenofovir disoproxil fumarate|PROCEDURE: Pharmacokinetic Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Intraoperative Forced Air Warmer Use, On Postoperative Nausea And Vomiting
Status: UNKNOWN
Conditions: Hypothermia; Anesthesia|Nausea and Vomiting, Postoperative
Interventions: DEVICE: Bair hugger and Forces air warmer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of HRS-4642 in Patients With Advanced Solid Tumors Harboring KRAS G12D Mutation
Status: ENROLLING_BY_INVITATION
Conditions: Advanced KRAS G12D Mutant Solid Tumors
Interventions: DRUG: HRS-4642|DRUG: Adebrelimab|DRUG: SHR-A1921|DRUG: Pemetrexed Disodium for Injection、Cisplatin Injection、Carboplatin for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Phase 2 Study Evaluating the Value of Radiotherapy in Advanced Diffuse Large B-cell Lymphoma Patients With Extranodal Involvement and Large Tumors Undergoing Immunochemotherapy for PET-CT Assessment of Complete Remission
Status: NOT_YET_RECRUITING
Conditions: Advanced Diffuse Large B-Cell Lymphoma|Extra-nodal Involvement, Large Mass|Radiotherapy
Interventions: DRUG: 6-8 cycles (21 days per cycle) of Standard R-CHOP chemotherapy|RADIATION: Radiotherapy beyond standard R-CHOP Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparaison of Avatar Therapy to Cognitive Behavioral Therapy in Schizophrenia With Treatment Refractory Hallucinations
Status: RECRUITING
Conditions: Auditory Hallucination, Verbal|Treatment-resistant Schizophrenia
Interventions: BEHAVIORAL: Avatar Therapy|BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Efficacy of CD+A Compared to AQ+SP for the Treatment of P.Falciparum Malaria in Rwandan Children
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Chlorproguanil-dapsone + artesunate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examining the Effects of One-Month Probiotic Treatment on Mental Fatigue
Status: COMPLETED
Conditions: Mental Fatigue|Cognitive Function|Mood
Interventions: DIETARY_SUPPLEMENT: Probiotic formulation|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Feasibility of Contact Force Catheter Mapping and Ablation in Epicardial and Endocardial Ventricular Tachycardias
Status: UNKNOWN
Conditions: Ventricular Tachycardia|Sudden Death|Syncope|Chest Pain
Interventions: PROCEDURE: Catheter ablation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase III Randomized, Double-Blind, Placebo-Controlled Study of Antenatal Thyrotropin-Releasing Hormone in Pregnant Women With Threatened Premature Delivery
Status: COMPLETED
Conditions: Respiratory Distress Syndrome
Interventions: DRUG: betamethasone|DRUG: dexamethasone|DRUG: thyrotropin-releasing hormone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Aerobic Exercise for Adolescents With Subthreshold Mood Syndromes
Status: COMPLETED
Conditions: Depressive Symptoms|Hypomania Nos Single Episode or Unspecified
Interventions: BEHAVIORAL: aerobic exercise|BEHAVIORAL: Placebo controlled group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Immunogenicity Study of a 24-Valent Pneumococcal Conjugate Vaccine (VAX-24) in Older Adults
Status: COMPLETED
Conditions: Pneumococcal Vaccines
Interventions: BIOLOGICAL: 24-Valent Pneumococcal Conjugate Vaccine|BIOLOGICAL: Pneumococcal 20-valent Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Randomized Feasibility Trial for Mesh in Pre-Pectoral Reconstruction
Status: RECRUITING
Conditions: Breast Cancer|Breast Implant; Complications, Infection or Inflammation
Interventions: DEVICE: Acellular Dermal Matrix|PROCEDURE: Reconstruction without ADM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Implantation Potential of Embryos by Time-lapse Technology
Status: UNKNOWN
Conditions: Embryo/Fetus Death|Blastocyst Disintegration|Aneuploidy|Complication of Implant|Chemical Pregnancy
Interventions: DRUG: recombinant Follicle Stimulating Hormone (rFSH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging Neural Correlates of Ketamine Using PET/MR
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DRUG: Ketamine Hydrochloride|DRUG: Esketamine|DRUG: Placebo|DRUG: Pilot study II: Esketamine|DRUG: Pilot study II: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of the Dry Powder Formulation of GSK2269557 in Healthy Subjects
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK2269557|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Safety of Nintedanib in Myositis Associated Interstitial Lung Disease: a Pilot Study
Status: UNKNOWN
Conditions: Interstitial Lung Disease|Myopathy, Inflammatory
Interventions: DRUG: Nintedanib 150 milligrams [Ofev]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability Study of Oral Full-Spectrum MicrobiotaTM (CP101) in Subjects With Autism Spectrum Disorder and Associated GI Symptoms (SPROUT)
Status: WITHDRAWN
Conditions: Autism Spectrum Disorder|Autism|ASD|Autistic Thinking|Autistic Behavior|Finch|FMT|Fecal Microbiota Transplant|CP101|SPROUT|Fecal Transplant
Interventions: DRUG: CP101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Pain Intervention in Cesarean Sections
Status: COMPLETED
Conditions: Other Chronic Postoperative Pain
Interventions: DRUG: Duramorph 150|DRUG: Acetaminophen|DRUG: Duramorph 300
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerance and Pharmacokinetics of THR-1442 in Chinese Healthy Subjects
Status: UNKNOWN
Conditions: T2DM (Type 2 Diabetes Mellitus)
Interventions: DRUG: THR-1442 20mg Single dose|DRUG: THR-1442 20mg Multiple dose group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Cirmtuzumab and Ibrutinib in Patients With B-Cell Lymphoid Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: B-cell Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|Mantle Cell Lymphoma|Marginal Zone Lymphoma
Interventions: DRUG: Cirmtuzumab (2-16 kg/mg) plus Ibrutinib|DRUG: Cirmtuzumab (300mg) plus Ibrutinib|DRUG: Cirmtuzumab (600 mg) plus ibrutinib|DRUG: Cirmtuzumab (RDR) plus ibrutinib|DRUG: Cirmtuzumab plus ibrutinib|DRUG: Ibrutinib alone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of AZD4901 in Females With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome (PCOS), Female Endocrine Disorder
Interventions: DRUG: AZD4901 (oral)|DRUG: Placebo to match AZD4901
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of a Computer-Delivered 5 A's Intervention for Smoking
Status: TERMINATED
Conditions: Smoking
Interventions: BEHAVIORAL: Computer-directed 5 A's intervention for smoking|BEHAVIORAL: Screening and resource provision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Venetoclax and Acalabrutinib in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Blastoid Variant Mantle Cell Lymphoma|CCND1 Protein Overexpression|CD20 Positive|CD5 Positive|FCER2 Negative|Pleomorphic Variant Mantle Cell Lymphoma|Recurrent Mantle Cell Lymphoma|Refractory Mantle Cell Lymphoma|t(11;14)(q13;q32)
Interventions: DRUG: Acalabrutinib|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of the Effect of Ibudilast on Neuroinflammation in Methamphetamine Users
Status: RECRUITING
Conditions: Methamphetamine-dependence
Interventions: DRUG: Ibudilast|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Bioequivalence of a New Tapentadol Extended-Release 250-mg Tablet With Respect to a Tapentadol Extended-Release 250-mg Tablet in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tapentadol ER 250-mg TRF tablet|DRUG: Tapentadol ER 250-mg PR2 tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of RO5028442 in Adult Male High-Functioning Autistic Patients
Status: COMPLETED
Conditions: Autistic Disorder
Interventions: DRUG: Placebo|DRUG: RO5028442
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Paricalcitol on Albuminuria, Inflammation and Fibrosis on Proteinuric Chronic Renal Diseases (PALIFE Study)
Status: TERMINATED
Conditions: Chronic Kidney Disease, Unspecified
Interventions: DRUG: Experimental arm|OTHER: Comparator Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT