pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pharmacokinetics, Safety and Tolerability Study of Abacavir/ Dolutegravir/ Lamivudine Fixed-dose Combination Tablets in Healthy Japanese Subjects
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: ABC/DTG/3TC FDC tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Familiar Voice Stimulation During Coma Recovery
Status: COMPLETED
Conditions: Traumatic Brain Injury|Coma|Vegetative State|Minimally Conscious State
Interventions: BEHAVIORAL: Familiar Auditory Sensory Training|BEHAVIORAL: Sham Auditory Sensory Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose-Finding Study of RO4998452 in Patients With Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: Placebo|DRUG: RO4998452|DRUG: RO4998452|DRUG: RO4998452|DRUG: RO4998452|DRUG: RO4998452
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Extension Study To Enroll Subjects Who Were Enrolled In B5301001 Study
Status: TERMINATED
Conditions: Hypertrophic Scars Resulting From Prior Breast Scar Revision Surgery
Interventions: DRUG: PF-06473871|DRUG: PF-06473871
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Enzalutamide in Combination With Paclitaxel Chemotherapy or as Monotherapy Versus Placebo With Paclitaxel in Patients With Advanced, Diagnostic-Positive, Triple-Negative Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: Enzalutamide|DRUG: Placebo|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SOLSTICE Trial in China
Status: UNKNOWN
Conditions: Coronary Artery Disease|Calcifications Vascular
Interventions: DEVICE: Shockwave Coronary Intravascular Lithotripsy (IVL) System C2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Versus Delayed Intrauterine Device (IUD) Insertion Following First Trimester Suction Aspiration Procedures
Status: COMPLETED
Conditions: Contraception
Interventions: PROCEDURE: Immediate IUD insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Prevention of Childhood Maltreatment in Families With Young Children
Status: ENROLLING_BY_INVITATION
Conditions: Child Maltreatment|Child Exposure to Intimate Partner Violence
Interventions: BEHAVIORAL: Enhanced First Connections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Supportive Understanding and Patient-centered Partnership for Optimizing Renal Treatment
Status: RECRUITING
Conditions: Chronic Kidney Diseases|Racism, Systemic|Trauma, Psychological
Interventions: BEHAVIORAL: IMPaCT Community Health Worker Program|OTHER: Trauma-Informed Care Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Investigate the Safety, Tolerability and Effects of AZD8630 in Healthy Subjects and Subjects With Asthma on Inhaled Corticosteroids and Long-acting Beta-agonists
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: AZD8630|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: One Stage Correction of Congenital Penile Curvature Complex
Status: COMPLETED
Conditions: Congenital Anomaly|Chordee|Curvature of Penis|Torsion of the Penis
Interventions: PROCEDURE: Modified Nesbit's procedure and dorsal dartos flap
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Bioequivalence Study of Albuterol Sulfate Inhalation Aerosol, 0.09 mg Albuterol Base/ Inhalation
Status: WITHDRAWN
Conditions: Bronchial Asthma
Interventions: OTHER: Methacholine Chloride|DRUG: Albuterol Sulfate HFA 0.09 mg (Reference)|DRUG: Albuterol Sulfate HFA 0.18 mg (Reference)|DRUG: Albuterol Sulfate HFA 0.09 mg (Test)|DRUG: Albuterol Sulfate HFA 0.18 mg (Test)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive TMS and Occupational Therapy in Children and Young Adults With Chronic Hemiparesis
Status: TERMINATED
Conditions: Pediatric Stroke|Cerebral Palsy|Chronic Hemiparesis
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation|DEVICE: Sham Repetitive Transcranial Magnetic Stimulation|OTHER: Occupational Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of AK109 and AK104 in Advanced Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma
Status: RECRUITING
Conditions: Gastric Adenocarcinoma and Gastroesophageal Junction Adenocarcinoma
Interventions: BIOLOGICAL: AK109|DRUG: paclitaxel|DRUG: paclitaxel|BIOLOGICAL: AK104
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Boosting Open-Label Placebo Effects in Acute Induced Pain in Healthy Adults
Status: RECRUITING
Conditions: Acute Pain
Interventions: PROCEDURE: OLP-injection|OTHER: Scripted Evidence-based treatment rationale|OTHER: Experimental model of acute pain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Investigation of the Effects of Motor Imagery and Action Observation Training in Individuals With Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: OTHER: Motor Imagery training|OTHER: Action Observation training|OTHER: standard rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Accuracy of Core Body Temperature Measurement Depending on Oesophageal Probe Tip Location
Status: RECRUITING
Conditions: Emergencies|Hypothermia
Interventions: DIAGNOSTIC_TEST: Oesophageal temperature measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety Study of VB-1953 Topical Gel for Inflammatory Facial Acne Vulgaris
Status: UNKNOWN
Conditions: Acne Vulgaris
Interventions: DRUG: VB-1953 - 2%|DRUG: VB-1953 - 0% (Vehicle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Children With Primary Malignant Brain Tumors
Status: TERMINATED
Conditions: Childhood Brain Tumor
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Pharmacodynamics and Safety of HGS1025 in Patients With Ulcerative Colitis
Status: WITHDRAWN
Conditions: Ulcerative Colitis
Interventions: BIOLOGICAL: HGS1025|BIOLOGICAL: HGS1025|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Effects of Selpercatinib (LY3527723) on Midazolam in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Midazolam|DRUG: Selpercatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of End-expiratory Positive Pressure Optimization in Intubated Patients With Healthy Lung or Acute Respiratory Distress Syndrome
Status: UNKNOWN
Conditions: ICU Patients|Healthy Lung|Positive End-Expiratory Pressure|ARDS|Alveolar Recruitment Maneuver
Interventions: OTHER: Increasing PEEP setting|OTHER: Decreasing PEEP setting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Infrazygomatic Versus Intranasal Injection Sphinopalatine Ganglion Blockade Effect on Surgical Field in FESS
Status: COMPLETED
Conditions: Nasal Polyps
Interventions: PROCEDURE: infrazygomatic approach sphinopalatine ganglion block|PROCEDURE: intranasal injection approach of sphinopalatine ganglion block
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: A Study to Assess the Effects of Switching From a Biologic Treatment to Tildrakizumab Using Patient-reported Outcomes in Adult Participants With Moderate to Severe Plaque Psoriasis
Status: RECRUITING
Conditions: Plaque Psoriasis
Interventions: DRUG: Tildrakizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Osimertinib, Cetuximab, and Tucatinib for the Treatment of EGFR-Mutant Stage IV or Recurrent Non-small Lung Cell Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastatic Lung Non-Small Cell Carcinoma|Recurrent Lung Non-Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8
Interventions: BIOLOGICAL: Cetuximab|DRUG: Osimertinib|DRUG: Tucatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Back-to-back Endoscopy Versus Single-pass Endoscopy and Chromoendoscopy in IBD Surveillance
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|Colorectal Neoplasms
Interventions: PROCEDURE: Back-to-back high-definition white light endoscopy|PROCEDURE: single-pass high-definition white light endoscopy|PROCEDURE: chromoendoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Fexofenadine Hydrochloride 180 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Fexofenadine 180 mg tablets|DRUG: ALLEGRA® 180 mg tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Chemotherapy and Whole-Brain Radiation Therapy in Treating Patients With Primary Central Nervous System Non- Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: carmustine|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: methotrexate|DRUG: vincristine sulfate|RADIATION: low-LET cobalt-60 gamma ray therapy|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Long-Term Sequelae After Thrombophlebitis, i.e. Deep Venous Thrombosis of the Lower Extremities
Status: COMPLETED
Conditions: Deep Venous Thrombosis
Interventions: DRUG: unfractionated heparin|DRUG: Tinzaparin (Leo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Abuse Potential Study of Orally Administered HORIZANT in Healthy, Non-dependent, Recreational Drug Users
Status: COMPLETED
Conditions: Abuse Potential
Interventions: DRUG: Placebo|DRUG: Alprazolam 2 mg|DRUG: Gabapentin Enacarbil Immediate Release (GE-IR) 200 mg|DRUG: Gabapentin Enacarbil Immediate Release (GE-IR) 450 mg|DRUG: Gabapentin Enacarbil Immediate Release (GE-IR) 700 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Cervical Epidural Versus Cevical Facet Injection for Patients With Chronic Cervical Pain
Status: COMPLETED
Conditions: Intervention|Cervical|Epidural|Injection
Interventions: OTHER: Flouroscopic guidance cervical epidural versus cervical facet injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prophylactic Treatment: Lessdrops™ vs Standard Drops Regimen
Status: COMPLETED
Conditions: Cataract
Interventions: DRUG: Pred-Gati-Brom|DRUG: Prednisolone acetate 1% ophthalmic suspension|DRUG: Gatifloxacin Ophthalmic|DRUG: Bromfenac 0.075% Oph Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dopaminergic restauratIon by intraVEntriculaire Administration
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: A-dopamine|DRUG: optimized oral treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PCI in Advanced Triple Negative Breast Cancer Patients Who Response to 1st Line Chemotherapy
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Brain Metastasis
Interventions: RADIATION: prophylactic cranial irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Single Ascending Dose Study of AV-006 in Healthy Subjects
Status: UNKNOWN
Conditions: Bacterial Infections
Interventions: DRUG: Placebos|DRUG: AV-006
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Basiliximab Combined With Ruxolitinib as Second-line Treatment of Grade 3-4 Steroid-resistant aGVHD
Status: UNKNOWN
Conditions: Safety and Efficacy
Interventions: DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of NGR-hTNF as Single Agent in Patients Affected by Advanced or Metastatic Malignant Pleural Mesothelioma
Status: COMPLETED
Conditions: Malignant Pleural Mesothelioma
Interventions: DRUG: NGR-hTNF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Technology-Enabled Activation of Skin Cancer Screening for Stem Cell Transplant Survivors and Their Primary Care Providers, TEACH Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Skin Carcinoma
Interventions: OTHER: Computer-Assisted Intervention|DEVICE: Dermatoscope|OTHER: Educational Intervention|OTHER: Educational Intervention (Physician)|OTHER: Questionnaire Administration|OTHER: Text Message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of KQ-2003 CAR-T Cell Therapy for Patients With Relapsed or Refractory POEMS Syndrome
Status: NOT_YET_RECRUITING
Conditions: POEMS Syndrome
Interventions: BIOLOGICAL: KQ-2003 CAR T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of LB4330 in Patients With Advanced Solid Tumors（MEETCD8-001）
Status: RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: LB4330
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closed-loop Control of Postprandial Glucose Levels After Meals With Different Macronutrients Content in Adults With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: Patient's insulin pump|DRUG: Insulin|DEVICE: Dexcom G4 Platinum glucose sensor|OTHER: Single-hormone closed-loop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phenotypes, Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related Disorders
Status: RECRUITING
Conditions: Hereditary Spastic Paraplegia
Interventions: OTHER: Clinical rating scale to measure disease severity and progression|DIAGNOSTIC_TEST: Next-Gen Sequencing (NGS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation
Status: RECRUITING
Conditions: Heart Failure
Interventions: DRUG: Ziltivekimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Access Site for Enhancing PCI in STEMI for Seniors (SAFE STEMI for Seniors)
Status: TERMINATED
Conditions: Myocardial Infarction
Interventions: DEVICE: Single Vessel Disease|PROCEDURE: Multi-vessel Disease, Culprit Vessel Only|PROCEDURE: Multi-vessel Disease, Complete Revascularization|DEVICE: Medtronic Resolute family of stents|DEVICE: Volcano based pressure wires Verrata, Verrata Plus and any subsequent marketed Volcano pressure wire technology|DEVICE: Terumo Glidesheath Slender|DEVICE: Terumo TR Band Radial Compression Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous T Cells Redirected to EGFRVIII-With a Chimeric Antigen Receptor in Patients With EGFRVIII+ Glioblastoma
Status: TERMINATED
Conditions: Patients With Residual or Reccurent EGFRvIII+ Glioma
Interventions: BIOLOGICAL: CART-EGFRvIII T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Omega-3 Supplementation on the Cytokine and Lipid Profiles in Patients With Chronic Chagas Cardiomyopathy
Status: COMPLETED
Conditions: Chagas Cardiomyopathy
Interventions: DIETARY_SUPPLEMENT: Omega-3|DIETARY_SUPPLEMENT: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Influence of SLCO2B1 Polymorphism on the PK of Voriconazole in CYP2C19 PM
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Vfend (voriconazole) intravenous infusion|DRUG: Vfend (voriconazole) tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: ASA in Prevention of Ovarian Cancer (STICs and STONEs)
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer Prevention
Interventions: DRUG: Acetylsalicylic acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Non-Myeloablative Allogeneic Transplant for Myelodysplastic Syndromes and Myeloproliferative Disorders
Status: COMPLETED
Conditions: Myelodysplastic Syndromes|Myeloproliferative Disorders|Blood and Marrow Transplant (BMT)|Myelodysplastic Syndromes (MDS)|Myeloproliferative Disorders (MPD)
Interventions: PROCEDURE: nonmyeloablative allogeneic hematopoietic cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Placebo Controlled Study of Thalidomide in Patients With Mycobacterial and HIV Infections
Status: COMPLETED
Conditions: HIV Infections|Mycobacterium Infections|Tuberculosis
Interventions: DRUG: thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Increasing Access to Evidence-based Treatment for Chronic Pain and Opioid Use Disorder: Adapting Acceptance and Commitment Therapy for Opioid Treatment Programs
Status: COMPLETED
Conditions: Opioid Use|Opioid Use Disorder|Chronic Pain
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy (ACT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SSPC Evaluation on Carotid Artery Stenosis After Endarterectomy
Status: UNKNOWN
Conditions: Carotid Stenosis|Carotid Artery Diseases|Carotid Artery Plaque
Interventions: PROCEDURE: Carotid endarterectomy (CEA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Addressing Disparities in Food Access Among Young Children in Louisiana: A Farm to ECE Approach
Status: COMPLETED
Conditions: Food Insecurity|Health Knowledge, Attitudes, Practice|Nutrition, Healthy
Interventions: BEHAVIORAL: Farm to ECE programming
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: GLP-1 Agonism for Blocking Cocaine Euphoria and Self-Administration
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: cocaine hydrochloride|DRUG: exenatide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: PK, Safety and Tolerability Study of AVT02 (Adalimumab) Pre-filled Syringe (PFS) vs, AVT02 Autoinjector (AI)
Status: COMPLETED
Conditions: Phase 1
Interventions: DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using a Digital Application for Adolescents in Dropout of Care in Mental Health : Facilitate the Return in Classic Care With Telepsychiatry, Tchats, Forums and a Home Medical Team.
Status: RECRUITING
Conditions: Mental Health
Interventions: OTHER: Together
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prostaglandin Inhibition for Emphysema
Status: COMPLETED
Conditions: Emphysema
Interventions: DRUG: 600 mg ibuprofen three times daily for 48 weeks|OTHER: Placebo three times daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Carbon-dioxide Monitoring in Electrophysiological Procedures in Deep Sedation
Status: ACTIVE_NOT_RECRUITING
Conditions: Conscious Sedation During Procedure|Ablation of Arrhythmias
Interventions: DIAGNOSTIC_TEST: Standard monitoring + transcutaneous CO2 monitoring|DIAGNOSTIC_TEST: Standard monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Transcranial Direct Current Stimulation (tDCS) as an Adjunct to Cognitive Behaviour Therapy (CBT)
Status: UNKNOWN
Conditions: Depression
Interventions: DEVICE: Active tDCS + CBT|DEVICE: Sham tDCS + CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of The Phosphate Mobile App on Serum Phosphorus in Adult Hemodialysis Patients With Hyperphosphatemia
Status: COMPLETED
Conditions: Hyperphosphatemia|End Stage Renal Disease on Dialysis
Interventions: OTHER: Phosphate mobile app|BEHAVIORAL: One-off dietary counselling with a phosphate booklet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shamrock - Ultrasound/MR Image Fusion Guided Lumbar Plexus Block
Status: COMPLETED
Conditions: Hip Fractures|Anesthesia, Local|Pain, Postoperative
Interventions: PROCEDURE: Ultrasound/MR image fusion guided lumbar plexus block (Shamrock)|PROCEDURE: Ultrasound guided lumbar plexus block (Shamrock)|DRUG: Lidocaine-epinephrine added gadoterate meglumine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Artificial Intelligence vs. LIRADS in Diagnosing HCC on CT
Status: RECRUITING
Conditions: HCC|Liver Cancer
Interventions: DIAGNOSTIC_TEST: Prototype artificial intelligence algorithm|DIAGNOSTIC_TEST: LI-RADS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Allergy Potential of Omeza Collagen Matrix in Human Subjects Using the Skin Prick Method
Status: COMPLETED
Conditions: Allergic Reaction
Interventions: DEVICE: Test Article|OTHER: Positive Control|OTHER: Negative Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pilot Open Label Trial of HIV Therapy With d4T (Stavudine), ddI (Didanosine), Nelfinavir and Hydroxyurea in Subjects With Early Asymptomatic HIV Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Hydroxyurea|DRUG: Nelfinavir mesylate|DRUG: Stavudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Cost-Effectiveness of Fully-Automated Digital vs. Human Coach-Based Diabetes Prevention Programs
Status: ACTIVE_NOT_RECRUITING
Conditions: PreDiabetes|Hyperglycemia|Glucose, High Blood|Overweight|Prediabetic State|Impaired Glucose Tolerance|Obesity|Weight Loss|Lifestyle, Healthy|Lifestyle Risk Reduction|Lifestyle, Sedentary
Interventions: BEHAVIORAL: Digital Diabetes Prevention Program (dDPP)|BEHAVIORAL: Human Coach-based Diabetes Prevention Program (hDPP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: User Performance Evaluation of Contour® Plus One, Accu-Chek® Performa Connect, FreeStyle Optium Neo and OneTouch® Select Plus Blood Glucose Monitoring Systems Following ISO 15197:2013; EN ISO 15197:2015
Status: COMPLETED
Conditions: Diabetes
Interventions: DEVICE: Blood-Glucose Monitoring Systems for self-testing
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: A Study of MSI-1256F (Squalamine Lactate) To Treat "Wet" Age-Related Macular Degeneration
Status: TERMINATED
Conditions: Macular Degeneration
Interventions: DRUG: MSI-1256F (Squalamine Lactate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Monocytes and NK Cells Activity in Covid-19 Patients
Status: UNKNOWN
Conditions: COVID-19|Severe Acute Respiratory Syndrome Coronavirus 2|Immunomodulation
Interventions: DIAGNOSTIC_TEST: Study of immune-mediated mechanisms in patients tested positive for SARS-CoV-2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunogenicity and Safety of Quadrivalent HPV Vaccine in Healthy Chinese Female Subjects Aged 9 to 19 Years
Status: RECRUITING
Conditions: HPV Infections|Cervical Cancer Stage IIa|Vaginal Cancer|Genital Wart|CIN1|CIN2|CIN3
Interventions: BIOLOGICAL: 2-doses Group among 9-14 years|BIOLOGICAL: 3-doses Group among 9-19 years|BIOLOGICAL: 3-doses Group among 20-26 years
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of E.Coli Nissle 1917 in Patients With Mild (Stage 1-2) or Minimal Hepatic Encephalopathy
Status: COMPLETED
Conditions: Hepatic Encephalopathy|Liver Cirrhosis|End Stage Liver DIsease
Interventions: DIETARY_SUPPLEMENT: E.coli Nissle 1917|DRUG: Lactulose|DRUG: Rifaximin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chidamide + Celecoxib in Advanced Metastatic Colorectal Cancer (CCmCC)
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: chidamide|DRUG: celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Immunogenicity of Env (A,B,C,A/E)/Gag (C) DNA and gp120 (A,B,C,A/E) Protein/GLA-SE HIV Vaccines, Given Individually or Co-administered, in Healthy, HIV-1-Uninfected Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: env (A,B,C,A/E)/gag (C) DNA Vaccine|BIOLOGICAL: gp120 (A,B,C,A/E) Protein Vaccine|BIOLOGICAL: Placebo|BIOLOGICAL: GLA-SE adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Caudal Nalbuphine on Postoperative Analgesia in Children
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Nalbuphine plus Bupivacaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Capecitabine and Cetuximab as First-Line Therapy in Patients With Metastatic Wild Type Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Colorectal Cancer
Status: WITHDRAWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: capecitabine and cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacitidine With or Without Lenalidomide or Vorinostat in Treating Patients With Higher-Risk Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Myelomonocytic Leukemia|Chronic Myelomonocytic Leukemia-1|Chronic Myelomonocytic Leukemia-2|Myelodysplastic Syndrome|Myelodysplastic Syndrome With Excess Blasts|Myelodysplastic Syndrome With Excess Blasts-1|Myelodysplastic Syndrome/Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|OTHER: Laboratory Biomarker Analysis|DRUG: Lenalidomide|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TTNS Versus Sham Therapy for Children With iOAB (TaPaS Part I)
Status: TERMINATED
Conditions: Overactive Bladder Syndrome
Interventions: DEVICE: TTNS|DEVICE: TTNS Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma
Status: RECRUITING
Conditions: Glioma|Pilocytic Astrocytoma|Pilomyxoid Astrocytoma|Pleomorphic Xanthoastrocytoma|Ganglioglioma|Optic Pathway Glioma|Diffuse Astrocytoma
Interventions: RADIATION: Hippocampal-avoidance proton therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Cognitive Rehabilitation Therapy in Improving Cognitive Function of Attention Following Mild Traumatic Brain Injury
Status: COMPLETED
Conditions: Mild Traumatic Brain Injury|Cognitive Impairment
Interventions: OTHER: Structured cognitive rehabilitation therapy|OTHER: Patient-centred cognitive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Immunogenicity of the Vaccine Candidates ID93 + AP10-602 and ID93 + GLA-SE Administered Intramuscularly in Healthy Adult Subjects
Status: COMPLETED
Conditions: Tuberculosis
Interventions: OTHER: AP10-602|BIOLOGICAL: GLA-SE|BIOLOGICAL: ID93
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Letrozole Versus Observation in Patients With Newly Diagnosed Uterine Leiomyosarcoma
Status: TERMINATED
Conditions: Leiomyosarcoma|Uterine Neoplasm
Interventions: DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Celecoxib|DRUG: Docetaxel|DRUG: Prednisolone|DRUG: ADT|DRUG: Zoledronic Acid|DRUG: Abiraterone|RADIATION: Radiotherapy to the prostate|DRUG: Enzalutamide|DRUG: Metformin|DRUG: Transdermal Oestradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postprandial Effect of Breakfast Glycemic Index on Vascular Function, Insulinemia and Cognitive Performance (BGI Study)
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Control breakfast|OTHER: High glycemic index breakfast|OTHER: Low glycemic index breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Trans-perineal Repair With or Without Limited Internal Sphincterotomy for Treatment of Type I Anterior Rectocele
Status: COMPLETED
Conditions: Rectocele
Interventions: PROCEDURE: Transperineal repair with PIS|PROCEDURE: Transperineal repair without PIS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Placebo Controlled Study Comparing AZD1775+ Docetaxel Versus Placebo+Docetaxel to Treat Lung Cancer
Status: TERMINATED
Conditions: Previously Treated Non Small Cell Lung Cancer
Interventions: DRUG: AZD1775|DRUG: AZD1775 Placebo|DRUG: Antimitotic Agent|DRUG: pegfiligrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Telmisartan and Losartan in Primary Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Low dose of telmisartan|DRUG: High dose of telmisartan|DRUG: Low dose of losartan|DRUG: High dose of losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Efficacy of Weekly TV-1106 in Adults With Growth Hormone Deficiency
Status: COMPLETED
Conditions: Growth Hormone Deficiency
Interventions: DRUG: TV-1106|DRUG: Recombinant human growth hormone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Finding Study of Danggui Buxue Tang (Herbal Formula)on the Treatment of Menopausal Symptoms
Status: COMPLETED
Conditions: Postmenopausal
Interventions: DRUG: DBT-Danggui Buxue Tang
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Recombinant Zoster Vaccine for Kidney Transplant Recipients
Status: NOT_YET_RECRUITING
Conditions: Immunosuppression|Vaccine Response Impaired
Interventions: BIOLOGICAL: Recombinant zoster vaccine adjuvanted (SHINGRIX)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Dose-ranging Study of the Efficacy of ESN364 in Postmenopausal Women Suffering Vasomotor Symptoms (Hot Flashes)
Status: COMPLETED
Conditions: Menopause|Hot Flashes
Interventions: DRUG: Fezolinetant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy, Surgery, and Radiation Therapy With or Without Dexrazoxane and Trastuzumab in Treating Women With Stage III or Stage IV Breast Cancer
Status: TERMINATED
Conditions: Cardiac Toxicity|Inflammatory Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: dexrazoxane hydrochloride|DRUG: doxorubicin hydrochloride|DRUG: cyclophosphamide|DRUG: paclitaxel|BIOLOGICAL: trastuzumab|PROCEDURE: therapeutic conventional surgery|RADIATION: radiation therapy|DRUG: tamoxifen citrate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficiency of Donepezil in Elderly Patients for Prevention of POCD Dysfunction
Status: UNKNOWN
Conditions: Total Knee Arthroplasty|Fracture of Head of Femur Articular Displaced|Protrusion of Intervertebral Disc
Interventions: DRUG: Donepezil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Early Identification of TRD and Construction and Clinical Validation of NTBS Precision Technology
Status: RECRUITING
Conditions: Treatment-Resistant Depression
Interventions: DEVICE: non-invasive transcranial deep brain stimulation|DEVICE: Sham stimulation|DEVICE: Motor cortex stimulation|DEVICE: non-invasive transcranial deep brain stimulation with closed-loop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of REVLIMID (Lenalidomide) Versus Placebo in Patients With Low Risk Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: Lenalidomide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled Molgramostim in Pediatric Participants With Autoimmune Pulmonary Alveolar Proteinosis (aPAP).
Status: NOT_YET_RECRUITING
Conditions: Autoimmune Pulmonary Alveolar Proteinosis
Interventions: DRUG: Molgramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Redesigning the Surgical Pathway (PROMoTE)
Status: RECRUITING
Conditions: Delirium|Cognitive Impairment|Perioperative/Postoperative Complications|Cognitive Dysfunction|Cognitive Decline
Interventions: OTHER: Multicomponent delirium-risk prevention bundle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of CD19-CAR-DNT Cells in Autoimmune Diseases
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus|Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis|Idiopathic Inflammatory Myopathies|Systemic Sclerosis
Interventions: BIOLOGICAL: CD19-CAR-DNT cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pasireotide in the Treatment of Hypoglycemia Following Gastric Bypass Surgery
Status: UNKNOWN
Conditions: Hypoglycemia, Reactive
Interventions: DRUG: Pasireotide 0.3 MG/ML|DIAGNOSTIC_TEST: Meal tolerance test (MTT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment, Pain, and Opioids
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Pain
Interventions: BEHAVIORAL: Cognitive-Behavioral Therapy for Treatment Seeking|BEHAVIORAL: Pain treatment education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Estrogen Levels in Premenopausal Women Who Have Undergone Surgery for Breast Cancer and Are Receiving Triptorelin and Tamoxifen Citrate or Exemestane on Clinical Trial IBCSG 24-02
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: gas chromatography / tandem mass spectometry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of BCD-180 in Patients With Axial Spondyloarthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Axial Spondyloarthritis
Interventions: BIOLOGICAL: anti-TRBV9 monoclonal antibody, low dose|BIOLOGICAL: anti-TRBV9 monoclonal antibody, high dose|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Volasertib in Combination With Low-dose Cytarabine in Patients Aged 65 Years and Above With Previously Untreated Acute Myeloid Leukaemia, Who Are Ineligible for Intensive Remission Induction Therapy (POLO-AML-2)
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: Placebo|DRUG: Volasertib|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: GlObal Secondary Prevention strategiEs to Limit Event Recurrence After Myocardial Infarction. GOSPEL Study
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: BEHAVIORAL: multifactorial continued educational - behavioural programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effectiveness of Adhesive Versus Conventional Nasoalveolar Molding on Children With Unilateral Cleft Lip and Palate
Status: NOT_YET_RECRUITING
Conditions: Cleft Lip and Palate
Interventions: DEVICE: Nasoalveolar molding in unilateral cleft lip and palate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexpramipexole Renal PK Study
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis|Renal Insufficiency
Interventions: DRUG: Dexpramipexole (dose 1)|DRUG: Dexpramipexole (dose 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prospective Feasibility Study Evaluating EchoMark LP Placement and EchoSure Measurements for Subjects Requiring Arteriovenous Fistulae
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Diseases|Arteriovenous Fistula
Interventions: DEVICE: EchoMark
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BMS_PD-L1_onco : Assessment of the PD-L1 Protein as a Biomarker in Oncology and Hematology
Status: COMPLETED
Conditions: Diffuse Large B-cell Lymphoma|Hodgkin Lymphoma|Metastatic Breastcancer|Non-small Cell Lung Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy, Safety of Solution Containing Hyperosmolar Sodium Lactate Infusion for Resuscitation of Patients With Hemorrhagic Shock
Status: COMPLETED
Conditions: Hemorrhagic Shock
Interventions: DRUG: Hyperosmolar sodium lactate|DRUG: Ringer's lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home Exercise Intervention in Childhood Obesity
Status: COMPLETED
Conditions: Child Obesity
Interventions: OTHER: Web-based intervention with support|OTHER: Web-based intervention without support|OTHER: Traditional intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Comparison of Two Daily Disposable Contact Lenses in a Population of Daily Disposable Contact Lens Wearers
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Nelfilcon A contact lens|DEVICE: Narafilcon B contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of SCTV01E (a COVID-19 Vaccine) in Population Aged ≥18 Years
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19|SARS-CoV-2 Infection
Interventions: BIOLOGICAL: SCTV01E|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Reducing Tobacco Smoking: a Transcranial Direct Current Stimulation (TDCS) Telehealth Study
Status: RECRUITING
Conditions: Smoking Cessation
Interventions: DEVICE: Transcranial Direct Current Stimulation (tDCS)|OTHER: Mindfulness|OTHER: Sham - Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Most Total Pancreatectomies for Ductal Adenocarcinoma Can Be Replaced by Whipple Over the Splenic Artery: A Before and After Study
Status: RECRUITING
Conditions: Ductal Adenocarcinoma of the Pancreas
Interventions: PROCEDURE: Whipple over the splenic artery|PROCEDURE: Total pancreatectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Heart Rate Variability Biofeedback for Female Sexual Arousal Disorder
Status: COMPLETED
Conditions: Female Sexual Arousal Disorder
Interventions: BEHAVIORAL: HRV Biofeedback|BEHAVIORAL: Autogenic Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT