pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Inhaled Corticosteroids (ICS) on Pulmonary Endothelial Function in COPD
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Bevespi|DRUG: Bretzri
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Vitamin D3 Supplementation in Advanced Cancer Patients With Pain
Status: RECRUITING
Conditions: Vitamin D3|Advanced Cancer|Pain Cancer
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Early Treatment Versus Expectative Management of PDA in Preterm Infants
Status: COMPLETED
Conditions: Patent Ductus Arteriosus
Interventions: DRUG: Ibuprofen|OTHER: Expectative Management|DRUG: Indomethacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Adipose Tissue Stromal Vascular Fraction Cells for Rheumatoid Arthritis
Status: WITHDRAWN
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Autologous stromal vascular fraction cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coronary Microcirculatory Disease and Inflammation in Patients With Chronic Coronary Syndrome and no Significant Coronary Artery Stenosis
Status: UNKNOWN
Conditions: Coronary Artery Disease|Ischemia and No Obstructive Coronary Arteries|Ischemic Heart Disease|Microvascular Angina|Vasospastic Angina
Interventions: DIAGNOSTIC_TEST: Comprehensive functional diagnostics of coronary circulation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Silybin Supplementation During HCV Therapy With Pegylated Interferon-α2b Plus Ribavirin Reduces Depression and Increases Work Ability
Status: COMPLETED
Conditions: Work Ability|Depression
Interventions: DRUG: Silybin 94 mg + vitamin E 90 mg + phospholipids 194 mg|DRUG: sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vascular Effects of Penil revascularızatıon
Status: COMPLETED
Conditions: Erectile Dysfunction|Erectile Dysfunction Due to Arterial Disease|Erectile Dysfunction Due to Venous Disorder
Interventions: PROCEDURE: Penile revascularızation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Previously Untreated Advanced Non-Small Cell Lung Cancer (NSCLC)
Status: UNKNOWN
Conditions: Untreated Advanced Non-Small Cell Lung Cancer
Interventions: DRUG: Avastin, Alimta
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home Treatment of Patients With Pulmonary Embolism Based on Pro-Brain Natriuretic Peptide (BNP) Levels
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: PROCEDURE: home treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Trial With SIR-Spheres and Cetuximab +/- Erlotinib
Status: WITHDRAWN
Conditions: Advanced Cancers
Interventions: DEVICE: SIR-Spheres|DRUG: Cetuximab|DRUG: Erlotinib|PROCEDURE: Break-Through Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutrition in Patient With Critical Limb Ischemia
Status: RECRUITING
Conditions: Critical Limb Ischemia|Malnutrition|Nutritional Supplements
Interventions: DRUG: Ensure Surgery Immunonutrition Shake|DRUG: Ensure Enlive Advanced Nutrition Shake
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: MR Guided Laser Interstitial Thermal Therapy for the "Minimal Invasive" Treatment of Brain Metastasis and Primary Brain Tumors
Status: COMPLETED
Conditions: Brain Neoplasms|Brain Tumor|Brain Cancer|Recurrent Brain Tumor
Interventions: DEVICE: MR-guided Laser Interstitial Thermal Therapy System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Analgesic Efficacy of Loxapine in Patients With Refractory, Chemotherapy-induced Neuropathic Pain
Status: TERMINATED
Conditions: Neuropathic Pain
Interventions: DRUG: Loxapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapy-Based Games' Effects on Motor and Cognitive Skills in Intellectual Disabilities
Status: COMPLETED
Conditions: Intellectual Disability
Interventions: OTHER: Mobile app-based game group|OTHER: Supervised combined sensor-based game group|OTHER: Individualized occupational therapy group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Study of Ozanimod With Tyramine to Evaluate the Effect on Pressor Response
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Phenelzine|DRUG: Tyramine|DRUG: Phenelzine placebo|DRUG: ozanimod placebo|DRUG: ozanimod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Electronic Portal Messaging and Embedded Asynchronous Care on Physician-Assisted Smoking Quit Attempts
Status: COMPLETED
Conditions: Smoking, Tobacco
Interventions: BEHAVIORAL: Physician Sent Outreach with Embedded Asynchronous Care in Portal Message|BEHAVIORAL: Physician Sent Outreach without Embedded Asynchronous Care in Portal Message|BEHAVIORAL: System Sent Outreach with Embedded Asynchronous Care in Portal Message|BEHAVIORAL: System Sent Outreach without Embedded Asynchronous Care in Portal Message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Metastatic Melanoma
Interventions: DRUG: Aldesleukin|DRUG: Fludarabine|DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Cyclophosphamide|DRUG: Cyclophosphamide|BIOLOGICAL: Young TIL|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimized Antiplatelet Therapy on the Prognosis of ACS Patients With Non-predominant Coronary Artery Disease After PCI
Status: UNKNOWN
Conditions: Acute Coronary Syndrome|Percutaneous Coronary Intervention
Interventions: PROCEDURE: Percutaneous coronary intervention|DRUG: Ticagrelor plus aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Luteal Support in Artificial Vitrified/Warmed Cycles With Low Progesterone
Status: RECRUITING
Conditions: IVF|Embryo Loss|Luteal Phase Defect
Interventions: DRUG: Progesteron TID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Uremic Pruritus, Cytokines and Polymethylmethacrylate Artificial Kidney
Status: COMPLETED
Conditions: Uremia|Pruritus
Interventions: PROCEDURE: Hemodialysis with Polymethylmethacrylate Artificial Kidney
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety and Efficacy of Teriflunomide in Patients With Relapsing Forms of Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: TERIFLUNOMIDE HMR1726
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of ET-1, Physical Activity, and Sedentary Behavior in Microvascular Dysfunction Following GDM
Status: NOT_YET_RECRUITING
Conditions: Gestational Diabetes|Endothelial Dysfunction|Physical Inactivity
Interventions: DRUG: Insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 2 Study of ABX-EGF (Panitumumab) in Japanese Subjects With M-colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: ABX-EGF (panitumumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Airway Protective Mechanisms in PD (R01)
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Capsaicin|DEVICE: Resistive respiratory loads|OTHER: Event-related evoked potential using electroencephalography (EEG).|PROCEDURE: Fluoroscopic swallow evaluation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: OSE as a Pre-procedural Mouth Rinse: A Clinical and Microbiological Study.
Status: COMPLETED
Conditions: Gingivitis|Periodontitis|Aerosol Disease|Gingival Disease|Periodontal Diseases
Interventions: PROCEDURE: Group PI|PROCEDURE: Group OC|PROCEDURE: Group CHX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Research on Effectiveness and Safety of the Treatment, Hyperthermic Intraperitoneal Chemotherapy Combined With Tislelizumab and Targeted Therapy, That is Used for High-risk Hepatocellular Carcinoma After R0 Resection
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: HIPEC+tislelizumab + targeted therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thrombotic Biomarkers to Predict Thrombosis in Heparin-induced Thrombocytopenia
Status: UNKNOWN
Conditions: Heparin-Induced Thrombocytopenia|Thrombosis|Biomarkers
Interventions: DIAGNOSTIC_TEST: HIT with thrombosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Is Kinesio Taping Effective to the Radial Nerve in Patients With Lateral Epicondylitis?
Status: COMPLETED
Conditions: Lateral Epicondylitis
Interventions: OTHER: Kinesio Tape|DRUG: oral naproxen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety of MB-102 (Relmapirazin) and the MediBeacon Transdermal GFR Measurement System in Evaluation of Kidney Function in Normal and Renal Compromised Subjects
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: MB-102|DEVICE: MediBeacon Transdermal Glomerular Filtration Rate Measurement System (TGFR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Effect of GRF6021 on Postoperative Recovery Following Primary Hip or Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Recovery
Interventions: BIOLOGICAL: GRF6021|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Micronutrients and Enteric Infections in African Children
Status: COMPLETED
Conditions: Enteric Infections
Interventions: DRUG: Vitamin + Zinc + micronutrient mixture|DRUG: Vitamin A|DRUG: Vitamin A + Zinc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Importance of Additional Protein to Benefit More From Training During and After Hospitalization
Status: COMPLETED
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Protein|DIETARY_SUPPLEMENT: Placebo|OTHER: Resistance training|DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adductor Canal Mid-thigh and Adductor Canal Distal Thigh: Is Cutaneous Sensory Blockade Similar Among Block Techniques?
Status: TERMINATED
Conditions: Postoperative Pain
Interventions: DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Revascularisation or Medical Therapy in Elderly Patients With Acute Anginal Syndromes
Status: COMPLETED
Conditions: Acute Coronary Syndromes
Interventions: DRUG: Conservative Arm|PROCEDURE: Invasive Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ATI-450 vs Placebo in Patients With Moderate to Severe Psoriatic Arthritis
Status: TERMINATED
Conditions: Psoriatic Arthritis
Interventions: DRUG: ATI-450|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adherence in Global Airways - Steroid Intake and Effects on Chronic Rhinosinosinutis
Status: RECRUITING
Conditions: Chronic Rhinosinusitis Without Nasal Polyps|Asthma|Chronic Rhinosinusitis With Nasal Polyps|Steroid-Induced Osteopenia (Diagnosis)|Steroid-Induced Diabetes|Steroid-Induced Hyperglycemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Step by Step: A Tailored Walking Intervention for Breast Cancer Survivors
Status: COMPLETED
Conditions: Sedentary Lifestyle|Breast Neoplasms|Survival Rate (Survivorship)
Interventions: BEHAVIORAL: Tailored Email|BEHAVIORAL: Targeted Email
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Multi-modality Physiotherapy in Delaying or Preventing COVID-19 Patient From Admitting to ICU
Status: UNKNOWN
Conditions: Covid19|Severe Systemic Illness Respiratory Muscle Fatigue
Interventions: DEVICE: Threshold IMT device|OTHER: Conventional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Outcomes Following Previously Administered Short-Term Treatment With SHP607 in Extremely Premature Infants
Status: TERMINATED
Conditions: Retinopathy of Prematurity (ROP)|Intraventricular Hemorrhage|Bronchopulmonary Dysplasia|Chronic Lung Disease of Prematurity
Interventions: OTHER: No Intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized MicroPort's Firehawk DES Versus Xience V: TARGET I Trial
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Firehawk|DEVICE: Xience V
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Prolonged Use of Topiramate for Preventing Migraine Headaches
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Topiramate|DRUG: Topiramate - Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Financially-Incentives to Improve Provider Compliance
Status: ACTIVE_NOT_RECRUITING
Conditions: Compliant Behavior|Morbidity;Infant
Interventions: BEHAVIORAL: Financially incentivized knowledge assessments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: First-in-Human Study of LHA510 in Elderly Subjects and Patients With Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: LHA510 Ophthalmic Suspension|DRUG: LHA510 Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Online Adaptive Radiotherapy Using a Novel Linear Accelerator (ETHOS)
Status: RECRUITING
Conditions: Prostate Cancer|Head and Neck Cancer|NSCLC|SCLC|Esophageal Cancer|Bladder Cancer|Rectum Cancer|Cervix Cancer|Other Carcinoma
Interventions: RADIATION: Online adaptive radiation therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of the Electro, Heat and Cold -Therapy During Physiotherapy Treatment in Osteoarthritis(OA) of KNEE
Status: WITHDRAWN
Conditions: Knee Pain|Osteoarthritis
Interventions: DEVICE: Elf care|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pain Prevalence, Distribution, Effect on Activities of Daily Life in Patients With Adolescent Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: Circumstances of pain|OTHER: Pain Questionnaire|OTHER: Gross Motor Functional Classification System|OTHER: The subtypes of Cerebral palsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Genotype-phenotype Correlations in Children and Adults With CTNNB1 Mutation
Status: COMPLETED
Conditions: CTNNB1 Gene Mutation
Interventions: DIAGNOSTIC_TEST: The Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F)|DIAGNOSTIC_TEST: The Autism Spectrum Quotient-Children's Version (AQ-Child)|DIAGNOSTIC_TEST: The Autism-Spectrum Quotient (AQ)-Adolescent Version (AQ-Adolescent)|DIAGNOSTIC_TEST: The Viking's Speech Scale|DIAGNOSTIC_TEST: The Functional Communication Classification System (FCCS)|DIAGNOSTIC_TEST: Brief Infant Sleeping Questionnaire (BISQ)|DIAGNOSTIC_TEST: Pediatric Sleep Questionnaire (PSQ)|DIAGNOSTIC_TEST: The Eating and Drinking Ability Classification System (EDACS)|DIAGNOSTIC_TEST: Mini Manual Ability Classification System (Mini-MACS)|DIAGNOSTIC_TEST: Manual Ability Classification System (MACS)|DIAGNOSTIC_TEST: The Gross Motor Function Classification System - Expanded and Revised (GMFCS - E&R)|DIAGNOSTIC_TEST: The Visual Function Classification System (VFCS)|DIAGNOSTIC_TEST: The Early Childhood Oral Health Impact Scale (ECOHIS)|DIAGNOSTIC_TEST: The Family Impact Scale (FIS)|DIAGNOSTIC_TEST: The Achenbach System of Empirically Based Assessment (ASEBA)|DIAGNOSTIC_TEST: Adaptive Behavior Assessment System Third Edition (ABAS-3)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Epidermal Growth Factor on Oral Mucositis Induced by Intensive Chemotherapy for Hematologic Malignancies
Status: COMPLETED
Conditions: Oral Mucositis
Interventions: DRUG: rhEGF + povidone iodine, chlorhexidine, & nystatin|DRUG: Placebo + povidone iodine, chlorhexidine, & nystatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Efficacy and Safety of Ianalumab Versus Placebo in Addition to Eltrombopag in Primary Immune Thrombocytopenia Patients Who Failed Steroids
Status: RECRUITING
Conditions: Primary Immune Thrombocytopenia
Interventions: BIOLOGICAL: Ianalumab|DRUG: Eltrombopag|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gastrointestinal Motility Among Diabetes Patients
Status: TERMINATED
Conditions: Diabetic Autonomic Neuropathy|Gastrointestinal Motility Disorder|Diabetes Mellitus|Change of Transit or Circulation
Interventions: RADIATION: 11C Donepezil PET/CT scan|DEVICE: 3D-Transit|DRUG: 3D-Transit during treatment with Pyridostigmine|DEVICE: 3D-Transit after Malone appendicostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Peripherally Inserted Central Catheter (PICC) Thrombosis: Reverse Taper Versus Non-tapered Catheters
Status: COMPLETED
Conditions: Venous Thrombosis
Interventions: DEVICE: Tapered PICC|DEVICE: Non-tapered PICC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nitric Oxide Nasal Spray (NONS) To Treat and Prevent the Exacerbation of Infection in Individuals With Mild COVID-19
Status: COMPLETED
Conditions: SARS-CoV-2 Infection
Interventions: DRUG: Nitric Oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Daily Isoniazid to Prevent Tuberculosis in Infants Born to Mothers With HIV
Status: TERMINATED
Conditions: HIV Infection|Tuberculosis|Pneumocystis Jiroveci Pneumonia
Interventions: DRUG: Isoniazid (INH)|DRUG: Trimethoprim/Sulfamethoxazole (TMP/SMX)|DRUG: Isoniazid Placebo (PL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Alpha/Beta T and CD19+ Depleted Peripheral Stem Cells for Patients With Primary Immunodeficiencies
Status: RECRUITING
Conditions: Immunodeficiencies|Immune Dysregulation Syndromes
Interventions: DEVICE: Apha/beta T and CD19+ cell depletion using CliniMACS device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Anti-COVID-19 Antibody SA58 Nasal Spray to Prevent Infection in High-risk Populations
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: DRUG: SA58 Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Enhanced DPP-GLB to Promote Weight Loss Among Nonresponders in a Community-Based Lifestyle Intervention.
Status: RECRUITING
Conditions: Diabetes
Interventions: BEHAVIORAL: DPP-GLB Standard|BEHAVIORAL: DPP-GLB Enhanced
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: RCT of Mesh Versus Jet Nebulizers on Clinical Outcomes During Mechanical Ventilation in the Intensive Care Unit
Status: COMPLETED
Conditions: Respiratory Insufficiency
Interventions: DEVICE: Vibrating Mesh Nebulizer Arm|DEVICE: Jet Nebulizer Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Proof of Concept Window Trial of the IMmunological Effects of AveLumab and Aspirin in Triple-Negative Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Avelumab|DRUG: Aspirin|DRUG: Lansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acetaminophen Versus Ibuprofen in Children With Asthma
Status: COMPLETED
Conditions: Asthma|Wheezing
Interventions: DRUG: Acetaminophen|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution
Status: ACTIVE_NOT_RECRUITING
Conditions: Lennox Gastaut Syndrome|Dravet Syndrome|Tuberous Sclerosis Complex
Interventions: DRUG: Cannabidiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erythropoietin Treatment in Patients With Systolic Left Ventricular Dysfunction, Mild Anemia and Normal Renal Function
Status: UNKNOWN
Conditions: Heart Failure
Interventions: DRUG: erythropoietin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tauroursodeoxycholic Acid (TUDCA) in New-Onset Type 1 Diabetes
Status: UNKNOWN
Conditions: Type 1 Diabetes
Interventions: DRUG: Tauroursodeoxycholic Acid (TUDCA)|DRUG: Sugar Pill (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of an Investigational Nasal Aerosol or Placebo Nasal Aerosol in Children (Ages 6-11) With Seasonal Allergies
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis|SAR
Interventions: DRUG: BDP HFA|DRUG: Placebo nasal aerosol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept Study of an Oral Orthotic to Reduce Tic Severity in Chronic Tic Disorder and Tourette Syndrome
Status: COMPLETED
Conditions: Tourette Syndrome|Chronic Tic Disorder
Interventions: DEVICE: Active Oral Orthotic Treatment|DEVICE: Placebo Oral Orthotic Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chidamide Combined With R-GDP in Treating Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL)
Status: UNKNOWN
Conditions: Chidamide|Lymphoma, B-Cell|Lymphoma, Large B-Cell, Diffuse|Neoplasm by Histology|Neoplasms|Lymphoproliferative Disorders|Lymphatic Diseases|Immunoproliferative Disorders|Immune System Diseases|Lymphoma, Non-Hodgkin|Cyclophosphamide|Rituximab|Gemcitabine|Cisplatin|Dexamethasone|HDAC Inhibitor
Interventions: DRUG: Chidamide combined with R-GDP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Examine Safety, Pharmacokinetics, And Pharmacodynamic Of Pf 06412562 In Subjects With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: PF-06412562 3mg BID|DRUG: PF-06412562 9mg BID|DRUG: PF-06412562 45mg BID|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate Safety & Efficacy of NaBen® as Add-on Treatment for Schizophrenia in Adults
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: NaBen®|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adefovir Dipivoxil In Compensated Chronic Hepatitis B Patients
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: LAM group|DRUG: ADV group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination With Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL)
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Venetoclax|DRUG: Acalabrutinib|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetically Modified Neural Stem Cells, Flucytosine, and Leucovorin for Treating Patients With Recurrent High-Grade Gliomas
Status: COMPLETED
Conditions: Adult Anaplastic Astrocytoma|Adult Anaplastic Oligodendroglioma|Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Recurrent Adult Brain Tumor|Anaplastic Oligoastrocytoma
Interventions: BIOLOGICAL: E. coli CD-expressing genetically modified neural stem cells|DRUG: flucytosine|DRUG: leucovorin calcium|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation (tDCS) As A Treatment For Cigarette Craving and Cognitive Deficits in Schizophrenic
Status: COMPLETED
Conditions: Schizophrenia|Cognition|Cigarette Smoking
Interventions: DEVICE: tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hysterosalpingography and Hysteroscopy in ICSI
Status: UNKNOWN
Conditions: Infertility
Interventions: OTHER: occlusion of tubes|OTHER: non occlusion of tubes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Targeting PD-1 Therapy Resistance With Focused High or High and Low Dose Radiation in SCCHN
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer
Interventions: DRUG: Pembrolizumab|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neulasta in Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Neulasta (Pegylated)|DRUG: Placebo|DIETARY_SUPPLEMENT: Mixed Meal Tolerance Test (MMTT)|OTHER: Blood test|OTHER: DNA Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Homebased Training With Telemonitoring Guidance in Low to Moderate Risk Patients Entering Cardiac Rehabilitation
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Myocardial Infarction
Interventions: BEHAVIORAL: Home-based training|BEHAVIORAL: Centre-based training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Sequential Treatment With Daivobet (Betamethasone Dipropionate Plus Calcipotriol) and Daivonex (Calcipotriol) in Patients With Psoriasis.
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: calcipotriol hydrate [Daivonex]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of SGR-1505 in Mature B-Cell Neoplasms
Status: RECRUITING
Conditions: Mature B-Cell Neoplasm|Non Hodgkin Lymphoma|DLBCL|Waldenstrom Macroglobulinemia|MALT Lymphoma|Follicular Lymphoma|Pediatric-Type Follicular Lymphoma|IRF4 Gene Rearrangement|EBV-Positive DLBCL, Nos|Burkitt Lymphoma|Plasmablastic Lymphoma|High-grade B-cell Lymphoma|Primary Cutaneous Follicle Center Lymphoma|Primary Effusion Lymphoma|Mantle Cell Lymphoma|DLBCL Germinal Center B-Cell Type|Primary Mediastinal Large B Cell Lymphoma|T-Cell/Histiocyte Rich Lymphoma|ALK-Positive Large B-Cell Lymphoma|Primary Cutaneous Diffuse Large B-Cell Lymphoma|Splenic Marginal Zone Lymphoma|Chronic Lymphocytic Leukemia|Nodal Marginal Zone Lymphoma|HHV8-Positive DLBCL, Nos|Lymphoplasmacytic Lymphoma|Duodenal-Type Follicular Lymphoma
Interventions: DRUG: SGR-1505
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Supplementation for LIver VolumE Reduction Study (OLIVER) Study
Status: UNKNOWN
Conditions: Fatty Liver|Bariatric Surgery Candidate
Interventions: DIETARY_SUPPLEMENT: 2 capsules of Concentrated omega-3 triglycerides- fish 1000mg (600mg Eicosapentaenoic acid (EPA), 1400mg Docosahexaenoic acid (DHA)) per day
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: 131 I-MIBG in Treating Patients With Refractory or Relapsed Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: BIOLOGICAL: filgrastim|RADIATION: iobenguane I 131
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heart Failure With Normal Ejection Fraction (HFNEF) in Hemodialysed Patients: Beneficial Effect of Ivabradine
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Ivabradine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycolic Acid Plus Salicylic Acid in Treatment of Plane Wart
Status: COMPLETED
Conditions: Plane Wart
Interventions: OTHER: Glycolic Acid Plus Salicylic Acid in Treatment of Plane Wart
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transapical Beating-Heart Septal Myectomy in Patient With Hypertrophic Obstructive Cardiomyopathy: a Multi-Center Study
Status: RECRUITING
Conditions: Hypertrophic Obstructive Cardiomyopathy
Interventions: PROCEDURE: Transapical beating-heart septal myectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Vemurafenib Adjuvant Therapy in Participants With Surgically Resected Cutaneous BRAF-Mutant Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Vemurafenib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Endorphins in Perception of Dyspnea With Resistive Loading in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: naloxone|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficiency of γδ T Cell Against Liver Cancer
Status: COMPLETED
Conditions: Liver Cancer
Interventions: PROCEDURE: Cryosurgery or IRE surgery|BIOLOGICAL: γδ T cell|OTHER: γδ T cells/ A Cryosurgery or IRE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: EEG-fMRI Experiments During Anesthesia Induction With Propofol
Status: RECRUITING
Conditions: Anesthesia
Interventions: DRUG: Propofol|BEHAVIORAL: visual flickering stimulation at the alpha frequency
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Genomic and Proteomic Profiling Targets Influenced Treatment in Metastatic Breast Cancer
Status: WITHDRAWN
Conditions: Metastatic Breast Cancer|Breast Tumor|Advanced Gynecologic Cancer
Interventions: GENETIC: Genetic profiling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Abicipar Pegol in Patients With Diabetic Macular Edema
Status: COMPLETED
Conditions: Macular Edema
Interventions: DRUG: abicipar pegol|DRUG: ranibizumab|OTHER: sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Evaluate Efficacy of Grazoprevir + Elbasvir for 12 or 16 Weeks in Liver Transplant Recipients.
Status: WITHDRAWN
Conditions: Liver Transplantation|Hepatitis C
Interventions: DRUG: Grazoprevir 100 mg/day|DRUG: Elbasvir 50 mg/d|DRUG: Grazoprevir 100 mg/day|DRUG: Elbasvir 50 mg/day|DRUG: Ribavirin 1200 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cleveland Clinic Families Get Fit (CCFit) : A Family-based Activity-Monitor Intervention in Pediatric Obesity
Status: COMPLETED
Conditions: Obesity, Childhood
Interventions: BEHAVIORAL: Family Based Activity Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing Adductor Canal Block and Adductor Canal Block-Local Infiltration Analgesia for Post-operative Pain Management
Status: UNKNOWN
Conditions: ACL Tear|ACL|ACL Injury
Interventions: PROCEDURE: Local Infiltration Anesthetic|PROCEDURE: Local Infiltration Anesthetic + Adductor Canal Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose of Magnesium Sulfate Infusion in Obese
Status: RECRUITING
Conditions: Obese|Analgesia
Interventions: OTHER: Lactate ringer group|DRUG: Magnesium sulfate dose through real weight group|DRUG: Magnesium sulfate dose through corrected ideal weight group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: APCext : Effect of Temporary Porto-caval Shunt During Liver Transplantation on Function of Liver Graft From Extended Criteria Donor
Status: RECRUITING
Conditions: Liver Transplantation
Interventions: PROCEDURE: temporary porto-caval shunt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Regorafenib for Recurrent Grade 2 and 3 Meningioma (MIRAGE Trial)
Status: NOT_YET_RECRUITING
Conditions: Meningioma, Malignant
Interventions: DRUG: Regorafenib 40 MG Oral Tablet|DRUG: Local Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Clinical Study to Investigate the Effect of autoSTEM-OA and alloSTEM-OA in Participants With Knee Osteoarthritis
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: BIOLOGICAL: STEM-OA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of AFQ056 in Obsessive Compulsive Disorder (OCD) Patients Resistant to Selective Serotonin Reuptake Inhibitor (SSRI) Therapy
Status: TERMINATED
Conditions: Patient Diagnosed With OCD and Resistant to SSRI Treatment|Failed SSRI Over 12 Weeks at Appropriate Doses
Interventions: DRUG: AFQ056|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biodiversity Intervention and Atopic Sensitization
Status: NOT_YET_RECRUITING
Conditions: Atopy|Allergy|Allergic Rhinitis|Allergic Sensitisation
Interventions: COMBINATION_PRODUCT: Nature-based materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Safety and Efficacy Study to Evaluate a Glaucoma Therapy in Open-Angle Glaucoma or Ocular Hypertension Patients
Status: COMPLETED
Conditions: Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Glaucoma therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Exercise on Recent Onset Low Back Pain in the Emergency Department
Status: COMPLETED
Conditions: Low Back Pain
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: Advice to stay active and engaged in usual activities.|BEHAVIORAL: Advice on use of ice or heat|OTHER: Advise regarding use of medications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Topical Melatonin Application on Dental Implant Osseointegration and Marginal Bone Level
Status: UNKNOWN
Conditions: Alveolar Bone Loss
Interventions: DRUG: N-acetyl-5-methoxytryptamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quality of Life and Voice Perception in Patients Laryngoctomized Phonatory Wearers
Status: RECRUITING
Conditions: Quality of Life|Larynx Cancer
Interventions: DIAGNOSTIC_TEST: to assess the voice perception of the patient undergoing phonatory prosthesis placement surgery by evaluating the optimal score (>30) in terms of VHI.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Determine the Effect of Multiple Doses of BMS-955176 on the Electrocardiograph of Healthy Subjects
Status: TERMINATED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: BMS-955176, Placebo (Part 1)|DRUG: BMS-955176, Moxifloxacin, Placebo (Part 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Dolasetron Mesylate and Dexamethasone With or Without Aprepitant in Preventing Nausea and Vomiting in Patients Undergoing Oxaliplatin-Containing Chemotherapy for Gastrointestinal Malignancy
Status: TERMINATED
Conditions: Malignant Digestive System Neoplasm|Nausea and Vomiting
Interventions: DRUG: Aprepitant|DRUG: Dexamethasone|DRUG: Dolasetron Mesylate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mupirocin 2% Ointment Vs Spray Antibiotics on Temporary Hemodialysis Catheter
Status: COMPLETED
Conditions: Hemodialysis Complication|Hemodialysis Catheter Infection
Interventions: DRUG: Local antibiotic spray Neomycin sulphate 165,000 IU + Bacitracin zinc 12,500 IU|DRUG: Mupirocin 2% ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Precision Administration of Anti-thymocyte Globulin With or Without Verapamil
Status: NOT_YET_RECRUITING
Conditions: Type 1 Diabetes
Interventions: DRUG: Anti-thymocyte globulin (ATG)|DRUG: verapamil extended release capsule|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Routine Lymphadenectomy for Intrahepatic Cholangiocarcinoma
Status: COMPLETED
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: PROCEDURE: lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized Glucose Optimization Through Nutritional Intervention
Status: COMPLETED
Conditions: Obesity|Pre-diabetic|Type 2 Diabetes Mellitus
Interventions: OTHER: Optimal diet|OTHER: Suboptimal diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neurotomy to Treat Synkinesis Following Peripheral Facial Palsy
Status: RECRUITING
Conditions: Facial Paralysis|Facial Palsy|Peripheral Facial Palsy|Peripheral Facial Paralysis|Bell Palsy|Synkinesis
Interventions: PROCEDURE: Botox injection|PROCEDURE: Neurotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Empowerment for Major Surgery Preparation @ Home
Status: UNKNOWN
Conditions: Urologic Diseases|Cardiovascular Diseases|Thoracic Diseases|Orthopedic Disorder|Gastrointestinal Disease
Interventions: OTHER: multimodal prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Adding Cognitive Behaviour Therapy to Supervised Pilates-based Core Stability Training in Patients With Multiple Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis
Interventions: OTHER: pilates based core stability training and congnitive therapy|OTHER: Pilates based core stability training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metronidazole SC Penetrance With Moisturizers
Status: NOT_YET_RECRUITING
Conditions: Rosacea, Erythematotelangiectatic
Interventions: DRUG: Metronidazole cream|OTHER: Cetaphil moisturizer|OTHER: CeraVe moisturizer|OTHER: Eucerin Healing Lotion moisturizer|OTHER: Aveeno Calm and Restore Oat Gel moisturizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab, Carboplatin, Paclitaxel, and Radiation for the Treatment of Early-Stage Anal Cancer
Status: RECRUITING
Conditions: Anal Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Paclitaxel|DRUG: Carboplatin|RADIATION: Radiation|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Diarrheal Disease Due to Infection With Enterotoxigenic E. Coli (ETEC)
Status: COMPLETED
Conditions: Diarrhea
Interventions: BIOLOGICAL: E. coli ETVAX|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION