pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Efficacy and Safety of Ramosetron in Patients Undergoing Off Pump Coronary Artery Bypass Surgery
Status: COMPLETED
Conditions: Coronary Artery Bypass Graft Triple Vessel|Hypotension
Interventions: DRUG: Ramosetron|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of CINRYZE for Prevention of Angioedema Attacks in Children Ages 6-11 With Hereditary Angioedema
Status: COMPLETED
Conditions: Hereditary Angioedema (HAE)
Interventions: BIOLOGICAL: CINRYZE 500|BIOLOGICAL: CINRYZE 1000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of Rasagiline in Patients With Amyotrophic Lateral Sclerosis
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Rasagiline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Energy Balance & Weight Loss in Craniopharyngioma-related or Other Hypothalamic Tumors in Hypothalamic Obesity
Status: COMPLETED
Conditions: Hypothalamic Obesity
Interventions: DRUG: Exenatide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Durvalumab Plus Regorafenib vs Untreated Control in Stage IV Colorectal Cancer Patients With no Evidence of Disease (NED): VIVA Trial
Status: RECRUITING
Conditions: Colorectal Cancer Stage IV|No Evidence of Disease State
Interventions: DRUG: Durvalumab Injection for intravenous use 500 mg vial solution for infusion|DRUG: Regorafenib 30 mg capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogene-modified T (IgT) Cells Against Glioblastoma Multiforme
Status: ENROLLING_BY_INVITATION
Conditions: Glioblastoma Multiforme of Brain|Glioblastoma Multiforme
Interventions: BIOLOGICAL: Antigen-specific IgT cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Clinical Trial of Bevacizumab Injection
Status: COMPLETED
Conditions: Rectal Cancer|Lung Cancer|Ovarian Cancer|Cervical Cancer|Glioblastoma
Interventions: DRUG: Bevacizumab injection|DRUG: Bevacizumab injection（Avastin）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Biliary RFA of Malignant Bile Duct Obstruction
Status: UNKNOWN
Conditions: Cholangiocarcinoma|Bile Duct Obstruction
Interventions: PROCEDURE: SEMS alone|PROCEDURE: SEMS plus radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lipoic Acid and Omega-3 Fatty Acids for Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Lipoic acid and fish oil concentrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perception of Cohesion Within a Relationship (Dyadic Adjustment) on the Quality of Life of Patients With Prostate Cancer With Gonadotropin-releasing Hormone.
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Gonadotropin-releasing Hormone (GnRH) agonist therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Diagnostic Accuracy of Salivary Gamma-synuclein in Oral Malignant and Premalignant Lesions
Status: UNKNOWN
Conditions: Oral Cancer|Oral Lichen Planus|Oral Leukoplakia|Premalignant Lesion
Interventions: DIAGNOSTIC_TEST: Salivary Gamma-synuclein|DIAGNOSTIC_TEST: Incisional biopsy|DIAGNOSTIC_TEST: Conventional visual and tactile examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of iTBS on the Inhibition Control Function of BN
Status: UNKNOWN
Conditions: Feeding and Eating Disorders
Interventions: OTHER: DMPFC iTBS|OTHER: DLPFC iTBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Ablative Radiotherapy for Comprehensive Treatment of 4-10 Oligometastatic Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Tumors
Interventions: RADIATION: Palliative Radiation|DRUG: Chemotherapy|DRUG: Immunotherapy|DRUG: Hormones|OTHER: Observation|RADIATION: Stereotactic Ablative Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Reactogenicity of GlaxoSmithKline (GSK) Biologicals' Quadrivalent Split Virion Influenza Vaccine Fluarix Tetra (2015 Season Southern Hemisphere) in Adults 18 Years of Age and Above
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluarix Tetra
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Efficacy and Safety of Two Different Types of Botulinum Toxin Type A in Moderate to Severe Cervical Dystonia
Status: COMPLETED
Conditions: Spasmodic Torticollis
Interventions: BIOLOGICAL: botulinum toxin type A|BIOLOGICAL: botulinum toxin type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Universal CAR-T Cells Targeting AML
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: CLL-1, CD33, CD38 and/or CD123-specific universal CAR- T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Previously Untreated Stage I or Stage II Hodgkin's Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma
Interventions: BIOLOGICAL: bleomycin sulfate|DRUG: doxorubicin hydrochloride|DRUG: mechlorethamine hydrochloride|DRUG: prednisone|DRUG: procarbazine hydrochloride|DRUG: vinblastine sulfate|DRUG: vincristine sulfate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Chemoradiation +Gemcitabine +Continuous 5-FU (Fluorouracil) Followed by High Dose Brachytherapy/Stereotactic Radiation Boost in Locally Advanced Intra/Extrahepatic Cholangiocarcinoma
Status: TERMINATED
Conditions: Cancer
Interventions: DRUG: Fluorouracil (5-FU)|RADIATION: Brachytherapy or SBRT (Stereotactic body radiation therapy)|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Exploratory Clinical Study of Metronomic Capecitabine as Adjuvant Therapy in Locoregionally Advanced Hypopharyngeal Carcinoma
Status: RECRUITING
Conditions: to Explore Whether the Adjuvant Therapy of Metronomic Capecitabine Could Improve the Disease-free Survival of Locoregionally Advanced Hypopharyngeal Carcinoma
Interventions: DRUG: Capecitabine 500Mg Oral Tablet
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy/Safety Study of ACTIQ® for Opioid-Tolerant Children and Adolescents With Breakthrough Pain (BTP)
Status: COMPLETED
Conditions: Cancer|Breakthrough Pain
Interventions: DRUG: ACTIQ®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Trends In Oxygen Saturation In Healthy Term Infants In The First Few Days Of Life: The "TOST" Study
Status: COMPLETED
Conditions: Normative Oxygen Saturation Data Will Help us in|Discharge Planning|Describing Guidelines for Pulse Oximetry Screening|Identification of High Risk Infants
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Just-in-Time Interventions for Reducing Short-Term Suicide Risk
Status: NOT_YET_RECRUITING
Conditions: Suicide
Interventions: BEHAVIORAL: Phone call|BEHAVIORAL: Text messaging|BEHAVIORAL: Automated interactive smartphone-based tool|BEHAVIORAL: Non-interactive pop-up messages
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IORT Versus CCRT for Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer Stage IV
Interventions: RADIATION: Intraoperative radiotherapy (IORT)|DRUG: Sequential chemotherapy|RADIATION: Three dimensional conformal radiation therapy (3D-CRT)|DRUG: Concurrent chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PurTox (Botulinum Toxin Type A) for the Treatment of Adult Onset Spasmodic Torticollis/Cervical Dystonia
Status: COMPLETED
Conditions: Spasmodic Torticollis
Interventions: DRUG: Mentor Purified Toxin, Botulinum Toxn Type A, Purified Neurotoxin|OTHER: Physiologic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of EGFR Mutations in Pancreatic Cancer Patients Receiving Gemcitabine With or Without Erlotinib
Status: UNKNOWN
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Cerebral Oxygenation Studies During Laparoscopy Procedure
Status: COMPLETED
Conditions: Increase in Intra-abdominal Pressure|Increase in Intracranial Pressure (ICP)|Laparoscopy|Cerebral Perfusion and Oxygenation
Interventions: PROCEDURE: Laparoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Pharyngeal Electrical Stimulation on Peripheral Biomechanical Aspects of Deglutition
Status: RECRUITING
Conditions: Dysphagia Following Cerebrovascular Accident|Dysphagia
Interventions: DEVICE: Pharyngeal Electrical Stimulation|OTHER: Sham treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Tenofovir Alafenamide (TAF) Versus Tenofovir Disoproxil Fumarate (TDF) in Participants With Chronic Hepatitis B Infection Who Are Negative for Hepatitis B e Antigen
Status: COMPLETED
Conditions: HBeAg-negative Chronic Hepatitis B
Interventions: DRUG: TAF|DRUG: TDF|DRUG: TAF Placebo|DRUG: TDF Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Clindamycin Gel 1% in Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Clindamycin 1% Gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aliskiren Study of Safety and Efficacy in Senior Hypertensives
Status: WITHDRAWN
Conditions: Hypertension
Interventions: DRUG: Aliskiren|DRUG: Amlodipine|DRUG: Ramipril|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Effectiveness of a Therapist-Assisted Self-Management Program for Veterans Who Finished PTSD Therapy
Status: ENROLLING_BY_INVITATION
Conditions: PTSD|Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: EMPOWER|OTHER: Treatment As Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Dasatinib and Radical Cystectomy for Transitional Cell Carcinoma of the Bladder
Status: COMPLETED
Conditions: Transitional Cell Carcinoma of the Bladder
Interventions: DRUG: Dasatinib|PROCEDURE: Radical Cystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peripheral Stem Cell Transplant, White Blood Cell Infusions, Chemotherapy, and Radiation Therapy in Treating Patients With Recurrent Metastatic Cervical or Vaginal Cancer
Status: COMPLETED
Conditions: Cervical Cancer|Vaginal Cancer
Interventions: BIOLOGICAL: therapeutic allogeneic lymphocytes|DRUG: cyclosporine|DRUG: fludarabine phosphate|DRUG: mycophenolate mofetil|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Hip Fracture Surgery
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: DU-176b (edoxaban)|DRUG: Enoxaparin sodium 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intravenous Ascorbic Acid Supplementation in Neoadjuvant Chemotherapy for Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Ascorbic Acid|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of MEDITOXIN® in Subject With Idiopathic Overactive Bladder
Status: UNKNOWN
Conditions: Overactive Bladder
Interventions: DRUG: Neuronox|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preemptive and Postoperative Intra-articualr Injection of Levobupivacaine and Tramadol
Status: COMPLETED
Conditions: Pain After Knee Arthroscop
Interventions: DRUG: Levobupivacaine Hydrochloride 2.5 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: "InMotion" - Physical Training With Creative Movement as an Intervention for Adults With Schizophrenia
Status: ACTIVE_NOT_RECRUITING
Conditions: Schizophrenia and Related Disorders
Interventions: OTHER: Creative physical training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Dose Bupivacaine Spinal for Trans Uretral Prostatectomy.
Status: UNKNOWN
Conditions: Benign Prostate Hyperplasia
Interventions: DRUG: Heavy Bupivacaine|DRUG: Isobaric Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study of AK112, a PD-1/VEGF Bispecific Antibody, for Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor, Adult
Interventions: DRUG: AK112
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spreading Depolarization and Ketamine Suppression
Status: COMPLETED
Conditions: Cortical Spreading Depolarization|Cortical Spreading Depression|Subarachoid Hemorrhage|Traumatic Brain Injury
Interventions: DRUG: ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Whole Course Multi-model Prehabilitation to Improve Clinical Outcome in Patients Undergoing Neoadjuvant Treatment Prior to Gastrectomy
Status: RECRUITING
Conditions: Gastric Cancer|Prehabilitation
Interventions: BEHAVIORAL: Multimodal prehabilitation program|BEHAVIORAL: ERAS program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Community-based Intervention Effects on Older Adults' Physical Activity
Status: COMPLETED
Conditions: Exercise|Physical Activity|Accidental Fall|Motivation|Older Adults
Interventions: BEHAVIORAL: Otago Exercise Program|DEVICE: Physical activity monitors (e.g., Fitbit)|BEHAVIORAL: Interpersonal Behavior Change Strategies|BEHAVIORAL: Intrapersonal Behavior Change Strategies|OTHER: Information about Health and Wellness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Variability in Analgesic Response to Ibuprofen
Status: NOT_YET_RECRUITING
Conditions: Impacted Third Molar Tooth|Pain, Acute
Interventions: DRUG: Ibuprofen 400 mg|DRUG: Acetaminophen 500mg|DRUG: OxyCODONE 5 mg Oral Tablet
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Prospective, Open-label Study of [68Ga]Ga-DOTA-TATE in Patients With Neuroendocrine Neoplasms (NENs) and Healthy Volunteers in Japan
Status: RECRUITING
Conditions: Neuroendocrine Neoplasms
Interventions: DRUG: [68Ga]Ga-DOTA-TATE|DRUG: 68Ge/68Ga Generator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Rate Of Delivery on Colonic Fermentation of inuliN (EON)
Status: COMPLETED
Conditions: Irritable Bowel
Interventions: DIETARY_SUPPLEMENT: psyllium|DIETARY_SUPPLEMENT: inulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Greenlight Vaporization vs Xpeeda Vaporesection
Status: ACTIVE_NOT_RECRUITING
Conditions: Benign Prostatic Hyperplasia|Lower Urinary Tract Symptoms
Interventions: PROCEDURE: Xpeeda Fibre Laser Vaporesection of the Prostate|PROCEDURE: Greenlight XPS Vaporization of the Prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of a Multi Strain Probiotic on the Gut Microbiota
Status: COMPLETED
Conditions: Microbial Colonization
Interventions: OTHER: Fasted breath samples|OTHER: Daily Diary|OTHER: Stool sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intraperitoneal Mesh With 3cm Overlap Versus a Rives-Stoppa Repair With a 6cm Overlap in Hernia Umbilicalis
Status: COMPLETED
Conditions: Hernia, Umbilical
Interventions: DEVICE: Ventralex versus Leight Weight Vypro II prothesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Intravitreal EBI-031 Given as a Single or Repeat Injection to Subjects With Diabetic Macular Edema
Status: WITHDRAWN
Conditions: Diabetic Macular Edema
Interventions: DRUG: EBI-031
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Retrograde rEperfusion in Dbd Donor LIver Transplantation
Status: UNKNOWN
Conditions: Liver Transplantation|Reperfusion|Delayed Graft Function
Interventions: PROCEDURE: Retrogade reperfusion|PROCEDURE: Antegrade reperfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Interventional Clinical Trial for CCSVI in Multiple Sclerosis Patients
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: PROCEDURE: Catheter venography with balloon venoplasty|DEVICE: Catheter venography with balloon venoplasty and balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MK-4827 in Combination With Pegylated Liposomal Doxorubicin in Participants With Advanced Solid Tumors and Ovarian Cancer (MK-4827-011)
Status: TERMINATED
Conditions: Ovarian Cancer
Interventions: DRUG: MK-4827 + pegylated liposomal doxorubicin|DRUG: MK-4827 + pegylated liposomal doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008, KEYVIBE-008)
Status: ACTIVE_NOT_RECRUITING
Conditions: Small Cell Lung Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab/Vibostolimab Co-Formulation|DRUG: Saline placebo|DRUG: Etoposide|DRUG: Cisplatin|BIOLOGICAL: Atezolizumab|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Dual Trigger on Intracytoplasmic Sperm Injection (ICSI) Reproductive Outcomes
Status: WITHDRAWN
Conditions: Pregnancy|Ovarian Hyperstimulation Syndrome
Interventions: PROCEDURE: final oocyte maturation trigger
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hypermobile Ehlers-Danlos Syndrome - Transcutaneous Auricular Neuromodulation
Status: RECRUITING
Conditions: Hypermobile Ehlers-Danlos Syndrome|Hypermobile Spectrum Disorder|Ehlers-Danlos Syndrome
Interventions: DEVICE: Transcutaneous Auricular Neurostimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stricture Definition and Treatment (STRIDENT) Drug Therapy Study
Status: UNKNOWN
Conditions: Crohn Disease|Inflammatory Bowel Diseases|Stricture; Bowel
Interventions: DRUG: Adalimumab Injection|DRUG: Thiopurine|PROCEDURE: Endoscopic balloon dilatation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of BCG Vaccine as a Preventive Measure for COVID-19 in Health Care Workers
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID 19 Vaccine
Interventions: BIOLOGICAL: BCG vaccine|BIOLOGICAL: 0.9% sodium chloride (NaCl) saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Erector Spinae Plane Block (ESP) Versus Thoracic Epidural Anesthesia in Video-Assisted Thoracoscopic Surgery (VATS) in Pediatric Population; a Randomized, Controlled Study
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: OTHER: Erector Spinae Plane Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of TPS on Cognitive Functions in Older Adults With MCI
Status: NOT_YET_RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: DEVICE: transcranial pulse stimulation|DEVICE: Sham TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Elastic Therapeutic Tapes on Performance With Healthy Subjects
Status: COMPLETED
Conditions: Sports Physical Therapy|Sports Performance
Interventions: OTHER: Rigid Tape|OTHER: Kinesiology Tape|OTHER: Biomechanical Tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Retinal Microanatomy in Retinopathy of Prematurity (BabySTEPS2)
Status: RECRUITING
Conditions: Retinopathy of Prematurity
Interventions: DEVICE: Investigational ultracompact OCT and OCTA system|DEVICE: retinal photographs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Targeting Effective Analgesia in Clinics for HIV - Intervention
Status: COMPLETED
Conditions: HIV Infection|Pain|Drug Dependence
Interventions: BEHAVIORAL: Collaboration with an IT enabled nurse care manager|BEHAVIORAL: Education and academic detailing|BEHAVIORAL: Facilitated access to a specialist in addictions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluating Mechanisms of Action of Adaptive Goal-Setting for Physical Activity
Status: COMPLETED
Conditions: Motivation|Physical Activity Promotion|Behavior Change|Mobile Health
Interventions: BEHAVIORAL: Remotely-delivered physical activity promotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Trial to Evaluate the Early Bactericidal Activity, Safety and Tolerability of Meropenem Plus Amoxycillin/CA and Faropenem Plus Amoxycillin/CA in Adult Patients With Newly Diagnosed Pulmonary Tuberculosis
Status: COMPLETED
Conditions: Pulmonary Tuberculosis
Interventions: DRUG: Meropenem|DRUG: Faropenem|DRUG: Amoxycillin/clavulanic acid|DRUG: Rifafour e275
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beta-Tricalcium Phosphate Bone Graft in Treating Patients Undergoing Surgery For Metastatic Spine Cancer
Status: TERMINATED
Conditions: Adult Spinal Cord Neoplasm|Spinal Bone Metastases|Spinal Cord Compression
Interventions: PROCEDURE: musculoskeletal complications management/prevention|PROCEDURE: bone graft|PROCEDURE: quality-of-life assessment|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Soft Tissue Therapy and Exercise on Hamstring Tightness
Status: COMPLETED
Conditions: Hamstring Tightness|Myofascial Pain|Musculoskeletal Pain
Interventions: OTHER: Neurodynamic Sliding|OTHER: Myofascial Decompression|OTHER: Diathermy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electronic Neurocognitive Tools in Screening for Mental Capability in Patients Undergoing Liver Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Liver and Intrahepatic Bile Duct Disorder
Interventions: BEHAVIORAL: BrainCheck Cognitive Assessment|PROCEDURE: Cognitive Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Efficacy and Safety of a New Artificial Tear Formulation Compared With Systane Ultra Multidose in Participants With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease (DED)
Interventions: DRUG: 011516X (New Artificial Tear Formulation)|DRUG: Systane Ultra Multidose|DRUG: REFRESH PLUS®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: MultiOmic characteriZation of Acute Myeloid Leukemia Evolving From myelopRoliferative Neoplasm to Identify New Targeted Therapeutic Strategies
Status: NOT_YET_RECRUITING
Conditions: Myeloproliferative Neoplasm|Secondary Leukemia
Interventions: OTHER: Multiomic characterization|OTHER: In vitro drug screening
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ibrutinib and Azacitidine for Treatment of Higher Risk Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndrome|Previously Treated Myelodysplastic Syndrome|Refractory Anemia With Excess Blasts in Transformation|Secondary Myelodysplastic Syndrome
Interventions: DRUG: Azacitidine|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Deep Topical Fornix Nerve Block Versus Topical Anaesthesia Procedure
Status: UNKNOWN
Conditions: Local Anesthesia|Satisfaction
Interventions: DRUG: 2% tetracaine local anaesthetic drops|DRUG: 0.5% bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Behavioral Change Following Alzheimer's Disease (AD) Biomarker Disclosure
Status: ENROLLING_BY_INVITATION
Conditions: Mild Cognitive Impairment|Alzheimer Disease|Amnestic Mild Cognitive Disorder
Interventions: BEHAVIORAL: Diagnostic Disclosure Protocol|BEHAVIORAL: Biomarker Disclosure Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase 1 Study of BGB-B2033, Alone or in Combination With Tislelizumab, in Participants With Advanced or Metastatic Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Metastatic Hepatocellular Carcinoma|Advanced Hepatocellular Carcinoma|Alpha-fetoprotein (AFP)-Producing Gastric Cancer|Extragonadal Yolk Sac Tumors|Glypican-3 (GPC3)-Positive Squamous Non-small Cell Lung Cancer|Metastatic Solid Tumor
Interventions: DRUG: BGB-B2033|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Daily Variability of Platelet Aggregation in Patients With Myocardial Infarction Treated With Prasugrel and Ticagrelor
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Prasugrel|DRUG: Ticagrelor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Project U Connect - Optimizing Brief Alcohol Intervention for Underage Drinkers in the ER
Status: COMPLETED
Conditions: Alcohol Misuse
Interventions: BEHAVIORAL: Computer-delivered Brief Intervention (CBI)|BEHAVIORAL: Intervener-delivered Brief Intervention (IBI)|BEHAVIORAL: Adapted Motivational Enhancement Therapy (AMET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Chemotherapy AND Bcl-xL Inhibitor (AT-101) For Organ Preservation In Adults With Advanced Laryngeal Cancer
Status: COMPLETED
Conditions: Laryngeal Cancer
Interventions: DRUG: AT-101|DRUG: Docetaxel|DRUG: Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Prevention Awareness Group (PAG) on Treatment Attendance and Drug Abstinence Among Substance User
Status: COMPLETED
Conditions: Substance Use Disorder|Drug Dependence,|Alcohol Dependence
Interventions: OTHER: Prevention Awareness Groups (PAG)|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ALPN-101 (Acazicolcept) in Systemic Lupus Erythematosus
Status: ACTIVE_NOT_RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: ALPN-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy of Omnivirol-Salicylic Acid Combination Therapy for Cutaneous Warts With Emphasis on Persistent Warts
Status: COMPLETED
Conditions: Cutaneous Warts
Interventions: DRUG: AV2-SA2|DRUG: SA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Versus Combined Antibiotic Therapy for Bacterial Peritonitis in CAPD Patients
Status: COMPLETED
Conditions: Peritonitis
Interventions: DRUG: ceftazidime+ciprofloxacin|DRUG: ceftazidime monotherapy|DRUG: cefazolin+gentamicin|DRUG: cefazolin monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of the NeoVista Ophthalmic System for the Treatment of Subfoveal CNV Associated With Wet AMD in Patients That Require Persistent Anti-VEGF Therapy
Status: UNKNOWN
Conditions: Age Related Macular Degeneration
Interventions: DEVICE: NeoVista Ophthalmic System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Relationship of Shear Wave Elastography Findings With Pain Threshold and Quality of Life in Patients With Lipedema
Status: COMPLETED
Conditions: Pain|Lipedema
Interventions: DIAGNOSTIC_TEST: SWE:B-mode ultrasound and subcutaneous elastic modulus with shear wave elastography at three level
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety and Efficacy Study of Oral Prolonged-Release Fampridine (BIIB041) in Japanese Participants With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis, Remittent Progressive|Multiple Sclerosis, Primary Progressive|Relapsing-Remitting Multiple Sclerosis|Secondary Progressive Multiple Sclerosis|Multiple Sclerosis
Interventions: DRUG: Placebo|DRUG: BIIB041 (fampridine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Intralesional Triamcinolone Injection With Whole Breast Detection Radical Surgery
Status: RECRUITING
Conditions: Refractory Granulomatous Lobular Mastitis
Interventions: OTHER: Intralesional triamcinolone injection|OTHER: No intralesional triamcinolone injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carboplatin and Paclitaxel With or Without Sorafenib Tosylate in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Mucosal Melanoma|Recurrent Melanoma|Stage IIIA Skin Melanoma|Stage IIIB Skin Melanoma|Stage IIIC Skin Melanoma|Stage IV Skin Melanoma
Interventions: DRUG: Carboplatin|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel|OTHER: Pharmacological Study|OTHER: Placebo|DRUG: Sorafenib Tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: HTMC0435 and Temozolomide in Treating Patients With Small Cell Lung Cancer
Status: RECRUITING
Conditions: Recurrent Extensive Stage Small Cell Lung Carcinoma
Interventions: DRUG: HTMC0435|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Bone Formation With Three Different Bone Graft Materials Following Sinus Graft
Status: COMPLETED
Conditions: Inadequate Bone Height in Maxillary Posterior Area
Interventions: PROCEDURE: Sinus augmentation|DRUG: Equimatrix|DRUG: OSSIF-i sem|DRUG: Bio-oss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Autopsy Follow-up of Subjects Previously Imaged With Florbetapir F 18 (18F-AV-45) PET in Trial 18F-AV-45-A07
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: florbetapir F 18
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Study of Venetoclax Combined With CACAG Regimen in the Treatment of Relapsed/Refractory Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Relapsed/Refractory Acute Myeloid Leukemia
Interventions: DRUG: Azacytidine;Cytarabine;Aclacinomycin;Chidamide;Venetoclax;Granulocyte colony-stimulating factor|DRUG: Best-Available Therapy(BAT) Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vortioxetine to Prevent Return of Symptoms in Children With Depression
Status: TERMINATED
Conditions: Depression
Interventions: DRUG: Vortioxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Health Impact of L.Reuteri Consumption in Crew Members of a Naval Ship at Sea
Status: COMPLETED
Conditions: Gingivitis
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Anti-CD25 rhMAb in the Treatment of Steroid-Refractory cGVHD
Status: NOT_YET_RECRUITING
Conditions: cGVHD
Interventions: DRUG: anti-CD25 rhMAb|DRUG: Prednisone|DRUG: Ruxolitinib|DRUG: Cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Analgesic Efficacy of Oxycodone Hydrochloride Versus Fentanyl After Total Hip Arthroplasty:
Status: COMPLETED
Conditions: Total Hip Arthroplasty|The Analgesic Efficacy
Interventions: DRUG: propofol, rocuronium and fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Testing of the Drug Tranexamic Acids as Prophylaxis of Bleeding in Benign Surgical Removal of the Uterus
Status: COMPLETED
Conditions: Gynecologic Surgical Procedures|Hysterectomy|Tranexamic Acid
Interventions: DRUG: Tranexamic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Trial to Evaluate the Effects of Itraconazole and Carbamazepine on the Pharmacokinetics of Emraclidine and of Emraclidine on the Pharmacokinetics of Metformin in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Emraclidine|DRUG: Itraconazole|DRUG: Carbamazepine|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Access Flow Based Intervention for Management of Arteriovenous Hemodialysis Access Dysfunction.
Status: UNKNOWN
Conditions: Hemodialysis Arteriovenous Fistula Maturation Failure
Interventions: PROCEDURE: Intra-procedural access flow|PROCEDURE: Standard Angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess EN3835 in the Treatment of Plantar Fasciitis (PFA)
Status: ACTIVE_NOT_RECRUITING
Conditions: Plantar Fasciitis
Interventions: BIOLOGICAL: EN3835|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of GSK Biologicals' Candidate Malaria Vaccine 257049 Against Malaria Disease in Infants and Children in Africa
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: Malaria Vaccine 257049|BIOLOGICAL: Meningococcal C Conjugate Vaccine|BIOLOGICAL: Cell-culture rabies vaccine|BIOLOGICAL: TritanrixHepB/Hib|BIOLOGICAL: Polio Sabin Oral Polio Vaccine (GSK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Blood-based Biomarkers for Diagnosis of Alzheimer's
Status: RECRUITING
Conditions: Dementia Alzheimers
Interventions: DIAGNOSTIC_TEST: predictive value of a blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Post-market Follow up Study of the 'BPK-S Integration' UC as Primary Implant in the Variants CoCr or Ceramic
Status: TERMINATED
Conditions: Osteoarthritis|Osteoarthritis, Knee|Joint Instability|Arthritis|Joint Disease|Musculoskeletal Disease|Rheumatic Diseases
Interventions: DEVICE: BPK-S Integration UC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of RO6927005 Either As Monotherapy (Part A) or in Combination With Gemcitabine and Nab-Paclitaxel (Part B) to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Clinical Activity in Patients With Mesothelin-positive Metastatic and/or Locally Advanced Malignant Solid Tumors
Status: TERMINATED
Conditions: Cancer
Interventions: DRUG: RO6927005|DRUG: RO6927005|DRUG: gemcitabine|DRUG: nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Intensity Interval Training (HIIT) for Patients With Cancer-related Lymphedema in the Lower Limbs
Status: COMPLETED
Conditions: Lymphedema of Leg|Cancer of Cervix|Cancer, Ovarian|Cancer, Endometrial|Cancer of the Prostate|Malignant Melanoma
Interventions: OTHER: First exercise session + compression|OTHER: First exercise session - compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized Trial to Assess Patient Quality of Life and Function After Alternative Surgeries for Pathologic Fractures of the Femur
Status: ACTIVE_NOT_RECRUITING
Conditions: Proximal Femoral Metastases
Interventions: PROCEDURE: long-stem cemented hemiarthroplasty (LSCH)|PROCEDURE: intramedullary nailing (IMN)|BEHAVIORAL: questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial in Patients With Metastatic or Locally Advanced Leiomyosarcoma
Status: RECRUITING
Conditions: Leiomyosarcoma of Ovary|Soft Tissue Sarcoma
Interventions: DRUG: Trabectedin|DRUG: Gemcitabine|DRUG: No Intervention: Observational Cohort
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Informative Video to Alleviate Anxiety and Improve Satisfaction in Elective Caesarean Section
Status: NOT_YET_RECRUITING
Conditions: Pre-operative Anxiety|Spinal Anesthesia|Satisfaction, Patient
Interventions: BEHAVIORAL: Informative Video on Perioperative Anxiety and Maternal Satisfaction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Deep Versus Moderate Neuromuscular Blockade
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: DRUG: Deep NMB using rocuronium|DRUG: Moderate NMB using rocuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Function Following Partial and Total Knee Replacement
Status: TERMINATED
Conditions: Osteoarthritis|Post-traumatic Arthritis
Interventions: DEVICE: Vanguard M fixed-bearing or Oxford mobile-bearing prostheses|DEVICE: Total Knee Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Additional 4 Cycles of Cisplatin (CDDP4) in Patients With Triple Negative Breast Cancer for Neoadjuvant Chemotherapy
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: AC4-CDDP4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of E/C/F/TAF Fixed Dose Combination (FDC) in HIV-1 Infected Adults on Chronic Hemodialysis
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: E/C/F/TAF|DRUG: B/F/TAF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Modes of Photodynamic Therapy for the Treatment of Actinic Keratosis on the Upper Extremities
Status: UNKNOWN
Conditions: Skin Neoplasms
Interventions: COMBINATION_PRODUCT: aminolevulinic acid hydrochloride gel, 10%|COMBINATION_PRODUCT: aminolevulinic acid HCl topical solution, 20%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab Combined With Pertuzumab for Adjuvant Treatment of Breast Cancer After Neoadjuvant Therapy
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Pyrotinib|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Bioequivalence Study of Nebcinal® 150mg/3ml Administered by Aeroneb® Idehaler® Versus Tobi® 300mg/5ml Administered by Pari LC Plus® /Pulmoaid® in Patients With Cystic Fibrosis
Status: UNKNOWN
Conditions: Cystic Fibrosis
Interventions: DRUG: Tobramycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT