pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: MANAGE Automated Glucose Monitoring
Status: UNKNOWN
Conditions: ICU/CCU Patients Requiring Blood Glucose Monitoring
Interventions: DEVICE: The OptiScanner|DEVICE: YSI 2300 STAT Plus™
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 1 Study of PPI-668 in Healthy Volunteers and Patients With Hepatitis C Virus (HCV) Genotype 1
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: PPI-668|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clazakizumab (Anti-Interleukin 6 (IL-6) Monoclonal) Compared to Placebo for Coronavirus Disease 2019 (COVID-19)
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Clazakizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers of Efficiency of Acceptance and Commitment Therapy in Suicidal Behavior
Status: COMPLETED
Conditions: Actual Suicidal Behavior Disorder
Interventions: BEHAVIORAL: Relaxation|BEHAVIORAL: ACT therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics and Pharmacodynamics, Efficacy and Safety of Omalizumab in Japanese Children (6 - 15 Years)
Status: COMPLETED
Conditions: Allergic Asthma
Interventions: DRUG: omalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy Between Robotic and Laparoscopic Total Gastrectomy in Patients With Clinical Stage I Gastric Cancer
Status: RECRUITING
Conditions: Stomach Neoplasm|Robotic Surgery
Interventions: PROCEDURE: Robotic Assisted Total Gastrectomy|PROCEDURE: Laparoscopic Assisted Total Gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Polymorphism of the GUCY1A3 rs7692387 Gene on Cardiovascular Events After Coronary Artery Bypass Grafting.
Status: RECRUITING
Conditions: to Evaluate the Association of GUCY1A3 rs7692387 Gene Polymorphism Carrier on the Development of Cardiovascular Events After Coronary Artery Bypass Grafting
Interventions: GENETIC: coronary artery bypass grafting
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Of Different Regimens In Patients With Type 2 Diabetes Receiving Intensive Insulin Therapy
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: metformin+empagliflozin+insulin glargine|DRUG: IDegLira|DRUG: premixed insulin analogues
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Pilot Study of the Safety and Efficacy of Topical MW-III in Thermal Burns
Status: RECRUITING
Conditions: Burns
Interventions: DRUG: Investigational Drug, MW-III|DRUG: Silvadene® Cream 1% [Silver Sulfadiazine]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Oral Immunotherapy Among Preterm Babies
Status: COMPLETED
Conditions: Feeding Behavior|Late-Onset Neonatal Sepsis
Interventions: OTHER: Sterile water|BIOLOGICAL: Breastmilk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Recto-intercostal Block for Coronary Artery Bypass Grafting
Status: RECRUITING
Conditions: Coronary Artery Disease|Peripheral Nerve Blocks|Sternotomy
Interventions: PROCEDURE: The recto intercostal fascial plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Escalated Dose of Irinotecan in mCRC
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: GENETIC: UGT1A1 genotyping (6,6)|GENETIC: UGTIA1 genotyping (6,7)|GENETIC: UGTIA1 genotyping (7,7)|GENETIC: UGT1A1 non-genotyping|DRUG: bevacizumab (Avastin)|DRUG: irinotecan|DRUG: Leucovorin|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Utilization of Cabozantinib in Adult Patients With Advanced or Metastatic Renal Cell Carcinoma (RCC) in 2nd Line Treatment Following Prior Vascular Endothelial Growth Factor (VEGF)-Targeted Therapy Under Real-real Life Clinical Setting in France.
Status: WITHDRAWN
Conditions: Renal Cell Carcinoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Two-unit Cantilever Implant Prostheses Made of Monolithic Zirconia or PFM
Status: RECRUITING
Conditions: Jaw, Edentulous, Partially|Missing Teeth
Interventions: DEVICE: Monolithic zirconia screw retained implant-supported cantilever reconstruction supported by titanium base abutments, in a full digital workflow (ZR-TiB)|DEVICE: porcelain fused-to metal screw retained implant-supported cantilever reconstruction supported by a gold-abutment, in a conventional workflow (PFM-GA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Rituximab Plus High-Dose Chemotherapy Poor Prognosis Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Lymphoma, Non-Hodgkin's
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing and Implementing an Interdisciplinary Team-Based Care Approach (ITCA-ThyCa) for Thyroid Cancer Patients
Status: WITHDRAWN
Conditions: Thyroid Cancer
Interventions: OTHER: Interdisciplinary Team-Based Approach|OTHER: Usual Care Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Factors Influencing the Results of Treatment in Patients With Hernias of Various Localizations
Status: RECRUITING
Conditions: Inguinal Hernia|Femoral Hernia|Umbilical Hernia|Ventral Hernia|Chronic Pain|Acute Post Operative Pain|Recrrence Rate
Interventions: PROCEDURE: open non-mesh hernia repair|PROCEDURE: open mesh hernia repair|PROCEDURE: MIS hernia repair
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nab-Paclitaxel and Gemcitabine for Recurrent/Refractory Sarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteosarcoma|Ewing Sarcoma|Rhabdomyosarcoma|Soft Tissue Sarcoma
Interventions: DRUG: nab-Paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Camrelizumab Combined With Chemotherapy Sequential Camrelizumab Combined With Apatinib Treatment of Advanced NSCLC
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Carrelizumab + chemotherapy + apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Continuous Haemofiltration vs Intermittent Haemodialysis on Microcirculatory Parameters in Septic Shock
Status: UNKNOWN
Conditions: Septic Shock
Interventions: DEVICE: muscle microdialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Safety and Immunogenicity of Vi-DT Typhoid Conjugate Vaccine (Bio Farma) in Adults and Children (Phase I)
Status: COMPLETED
Conditions: Safety Issues
Interventions: BIOLOGICAL: Vi-DT (Bio Farma)|BIOLOGICAL: Vi polysaccharide vaccine|BIOLOGICAL: Influenzae vaccine|BIOLOGICAL: Pneumococcal conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Low-Intensity Focused Ultrasound and the Complex Patient
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder|Chronic Pain|Anxiety Disorder
Interventions: DEVICE: Low-Intensity Focused Ultrasound|DEVICE: Low-Intensity Focused Ultrasound - sham
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dual Energy CT vs Standard Triple Phase CT-A Randomised Control Trial
Status: COMPLETED
Conditions: Renal Cell Carcinoma|Renal Cysts|Transitional Cell Carcinoma|AML
Interventions: OTHER: Standard multiphase CT|OTHER: split bolus Dual energy CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Zoledronic Acid for Osteoporotic Fracture Prevention (ZEST II)
Status: COMPLETED
Conditions: Osteoporotic Fractures|Osteoporosis, Postmenopausal
Interventions: DRUG: Zoledronic acid|DIETARY_SUPPLEMENT: vitamin D|DIETARY_SUPPLEMENT: calcium|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of DENSPM in Patients With Liver Cancer Who Are Not Eligible for Surgical Care
Status: TERMINATED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: DENSPM )
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REMStar Auto With C-Flex - In-Laboratory Performance v. Conventionally Titrated CPAP Therapy: Performances and Preferences
Status: COMPLETED
Conditions: Obstructive Sleep Apnoea Hypopnoea Syndrome
Interventions: DEVICE: REMStar Auto with C-Flex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Erwinase for Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) (IND 104224)
Status: TERMINATED
Conditions: Relapsed Acute Lymphoblastic Leukemia|Allergy to PEG e.Coli Asparaginase|Allergy to Native e.Coli Asparaginase
Interventions: DRUG: Erwinase|DRUG: Vincristine|DRUG: Dexamethasone|DRUG: Doxorubicin|DRUG: Cytarabine|DRUG: Methotrexate|DRUG: Triple Intrathecal Therapy|DRUG: Dexrazoxane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Prednisone in Patients With Severe Systemic Atheroembolism (Cholesterol Cristal Embolism)
Status: TERMINATED
Conditions: Cholesterol Embolism Systemic
Interventions: DRUG: prednisone|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pain and Success Rate in Pulpotomy Versus Root Canal Treatment
Status: UNKNOWN
Conditions: Pulpitis - Irreversible
Interventions: PROCEDURE: Pulpotomy|PROCEDURE: Root canal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transplantation of Human Embryonic Stem Cell-derived Progenitors in Severe Heart Failure
Status: COMPLETED
Conditions: Ischemic Heart Disease
Interventions: BIOLOGICAL: Human embryonic stem cell-derived CD15+ Isl-1+ progenitors
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Doppler(TCD) Evaluation of High Intensity Transient Signals and Carotid Disease
Status: WITHDRAWN
Conditions: Asymptomatic Carotid Stenosis|Symptomatic Carotid Stenosis|TCD|HITS
Interventions: DEVICE: Transcranial Doppler (TCD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Unobtrusive Monitoring of Affective Symptoms and Cognition Using Keyboard Dynamics (UnMASCK)
Status: ACTIVE_NOT_RECRUITING
Conditions: Mood Disorders|Major Depressive Disorder|Bipolar Disorder I|Bipolar Disorder II|Persistent Depressive Disorder (Dysthymia)|Cyclothymia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunogenicity, Safety and Tolerability of Two Doses of Adjuvanted and Non-adjuvanted Swine Origin A/H1N1 Monovalent Influenza Vaccine in Healthy Subjects From 6 Months to 17 Years of Age
Status: COMPLETED
Conditions: Pandemic Influenza
Interventions: BIOLOGICAL: Monovalent A/H1N1 influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Pilot RCT Local Gentamicin for Open Tibial Fractures in Tanzania
Status: COMPLETED
Conditions: Open Tibia Fracture
Interventions: DRUG: local gentamicin injection|DRUG: placebo saline injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation (FMT): PRIM-DJ2727
Status: AVAILABLE
Conditions: Recurrent Clostridium Difficile Infection|Multidrug-resistant Klebsiella Pneumoniae Urinary Tract Infection
Interventions: BIOLOGICAL: Fecal Microbiota Transplantation (FMT) product PRIM-DJ2727
Study Type: EXPANDED_ACCESS
Clinical trial: Internal Jugular Venous Distensibility Index and Innominate Venous Flow Patterns as Predictors of Fluid Responsiveness
Status: RECRUITING
Conditions: Fluid Responsiveness|Hemodynamic Monitoring
Interventions: DEVICE: Ultrasonography of Internal Jugular Vein|DEVICE: Doppler Echocardiograhy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pyrotinib Plus Thalidomide in Advanced NSCLC Patients Harboring HER2 Exon 20 Insertions
Status: UNKNOWN
Conditions: Non-small-cell Lung Cancer
Interventions: DRUG: pyrotinib combined with thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of PZ-128 in Subjects Undergoing Non-Emergent Percutaneous Coronary Intervention
Status: COMPLETED
Conditions: Arterial Occlusive Diseases|Coronary Artery Disease|Coronary Disease|Arteriosclerosis|Heart Diseases|Myocardial Ischemia|Vascular Diseases|Acute Coronary Syndrome
Interventions: DRUG: PZ-128|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase IIa Study to Assess the Safety, Efficacy, and Pharmacokinetics of Subcutaneously Administered Pegcetacoplan (APL-2) in Subjects With PNH
Status: COMPLETED
Conditions: PNH
Interventions: DRUG: Pegcetacoplan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Neonatal Care Education for Primiparous Pregnant Women on Postpartum Maternal Function and Quality of Life
Status: COMPLETED
Conditions: Life Quality|Functional Status
Interventions: BEHAVIORAL: Neonatal Care education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Esmolol to Treat the Hemodynamic Effects of Septic Shock
Status: TERMINATED
Conditions: Septic Shock|Hypotension|Tachycardia
Interventions: DRUG: Esmolol|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Study of the Intervention "Stop Sexual Harassment" in Secondary School
Status: COMPLETED
Conditions: Sexual Harassment|Anti-Gay Bias|Non Sexual Harassment|Gender-based Violence|Gender Bias|Bullying|Aggression|Depressive Symptoms|Anxiety|Mental Health
Interventions: BEHAVIORAL: Stop sexual harassment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of OFATUMUMAB as Part of the Scheme of Reduced Intensity Conditioning in High Risk Non-Hodgkin Lymphoma B Patients
Status: COMPLETED
Conditions: B-Cell Lymphomas
Interventions: DRUG: Ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acceptability and Feasibility of a Demedicalized Medical Abortion Regimen in the Caucasus
Status: COMPLETED
Conditions: Abortion, First Trimester
Interventions: DRUG: Home administration of 200 mg mifepristone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Anesthesia And Post-operative Mortality After Proximal Femur Fractures
Status: TERMINATED
Conditions: Hip Fractures
Interventions: PROCEDURE: Subarachnoid Anesthesia|PROCEDURE: PNB/GA|DRUG: ropivacaine|DRUG: sevoflurane or desflurane|DRUG: bupivacaine or levobupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sleep Health Program for Patients With Chronic Pain
Status: COMPLETED
Conditions: Sleep Disordered Breathing|Chronic Pain|Sleep
Interventions: BEHAVIORAL: Sleep Health Program for Participants with No/Mild Sleep Apnea|BEHAVIORAL: Sleep Health Program for Participants with Moderate/Severe Sleep Apnea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of a New Schedule of Capecitabine and Docetaxel to Treat Cancers
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Capecitabine|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BE of Euthyrox® Tablets (Merck Nantong Versus Merck Darmstadt Sites)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Test Euthyrox®|DRUG: Reference Euthyrox®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Assess Changes in Immunoglobulins in Patients With Relapsing Multiple Sclerosis Treated With Anti-CD20 Therapies
Status: COMPLETED
Conditions: Relapsing Multiple Sclerosis|Clinically Isolated Syndrome|Relapsing-remitting Multiple Sclerosis|Secondary Progressive Multiple Sclerosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bupivacaine in the Treatment of Postoperative Pain of Impacted Third Molar Extraction
Status: COMPLETED
Conditions: Teeth, Impacted
Interventions: DRUG: Bupivacaine-epinephrine|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Comprehensive Treatment in Patients With IR-CAD: a Self-controlled Cohort Study
Status: RECRUITING
Conditions: Coronary Artery Disease|Coronary Artery Stenosis|Coronary Artery Restenosis|Coronary Artery Disease Progression|Inflammation|Inflammatory Disease|Inflammation Vascular
Interventions: BEHAVIORAL: Healthy life style|DRUG: Secondary prevention for atherosclerotic coronary artery disease|DRUG: Immunosuppressive therapy|PROCEDURE: Coronary revascularization|DRUG: Supportive therapies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 1/2 Study of MRTX1719 in Solid Tumors With MTAP Deletion
Status: RECRUITING
Conditions: Mesothelioma|Non Small Cell Lung Cancer|Malignant Peripheral Nerve Sheath Tumors|Solid Tumor|Pancreatic Adenocarcinoma|Advanced Solid Tumor
Interventions: DRUG: MRTX1719
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept Open Label, Clinical Trial to Evaluate the Safety and Efficacy of the "FITT" Device in Diabetic Foot Ulcers Patients
Status: RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: Study treatment administration (TriO FITT)|DIAGNOSTIC_TEST: Physical Examination|DIAGNOSTIC_TEST: Vital Signs|DIAGNOSTIC_TEST: Hematology Blood Tests|DIAGNOSTIC_TEST: Biochemistry Blood Test|DIAGNOSTIC_TEST: Wound Digital Photography|DIAGNOSTIC_TEST: Urine pregnancy test|OTHER: Numeric Pain Rating Scale|OTHER: Visual Analogue Scale|OTHER: SF-36|DIAGNOSTIC_TEST: Wounds evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wound Closure After Total Knee Arthroplasty: Comparison of Polypropylene and Polyglactin 910 Suture.
Status: COMPLETED
Conditions: Wound Heal|Wound Dehiscence|Wound Complication
Interventions: PROCEDURE: wound closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Two Anti-HIV Drug Combinations in HIV-Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Delavirdine mesylate|DRUG: Lamivudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy of Iontophoresis in Treating Lateral Epicondylitis Patients
Status: RECRUITING
Conditions: Lateral Epicondylitis
Interventions: DRUG: Magnesium sulfate|OTHER: conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Anlotinib in Patients With Advanced Medullary Thyroid Carcinoma
Status: RECRUITING
Conditions: Medullary Thyroid Cancer
Interventions: DRUG: Anlotinib Hydrochloride Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Release of Acetylcholine From the Ganglionated Plexus During the Thaw Phase of Cryoballon Pulmonary Vein Ablation (GP RESPONSE Study)
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Cryoballoon ablation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of RO5083945 in Combination With FOLFIRI Versus FOLFIRI Plus Cetuximab or FOLFIRI Alone as Second Line Treatment in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: FOLFIRI|DRUG: RO5083945|DRUG: cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing Antiviral Treatments in Early Symptomatic RSV
Status: NOT_YET_RECRUITING
Conditions: Respiratory Syncytial Virus|Respiratory Syncytial Virus, Human
Interventions: DRUG: Ribavirin|DRUG: Molnupiravir|DRUG: Favipiravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Folate on DNA in Colon Tissue and Blood Samples From Patients at Increased Risk of Developing Colorectal Neoplasia
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: folic acid|GENETIC: DNA methylation analysis|GENETIC: gene expression analysis|GENETIC: microarray analysis|GENETIC: polymorphism analysis|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant and Adjuvant Toripalimab and Cetuximab in Patients With Recurrent, Resectable Squamous Cell Carcinoma of Head and Neck: a Prospective, Single-arm,Phase II Study
Status: RECRUITING
Conditions: Patients With Locally Recurrent Resectable Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Toripalimab+cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Risk Factors And Intensive Dietary Counselling
Status: UNKNOWN
Conditions: High Blood Pressure|Hypercholesterolemia|Tobacco Smoking
Interventions: BEHAVIORAL: Group-level Intensive dietary Counselling|BEHAVIORAL: Individual-level Intensive Dietary Counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Respiratory Physiology During High Flow Nasal Cannula Treatment in Preterm Neonates.
Status: UNKNOWN
Conditions: Extreme Prematurity - Less Than 28 Weeks|Respiratory Distress Syndrome in Premature Infants
Interventions: OTHER: Pharyngeal pressure|OTHER: Transcutaneous carbon dioxide|OTHER: Pharyngeal gas concentrations|OTHER: Tidal volume
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Modifications of the Subchondral Bone in Aseptic Osteonecrosis of the Femoral Head
Status: COMPLETED
Conditions: Femur Head Necrosis
Interventions: PROCEDURE: femoral head removal
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: MLN9708 for the Prophylaxis of Chronic Graft-versus-host Disease in Patient Undergoing Allogeneic Transplantation
Status: COMPLETED
Conditions: Allogeneic Hematopoietic Stem Cell Transplantation
Interventions: DRUG: MLN9708 (2.3 mg)|DRUG: MLN9708 (4.0 mg)|DRUG: MLN9708 (3.0 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Glucose Monitoring and Behavioral Change Intervention for People With Type 2 Diabetes and Diabetes Distress
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Self-Monitoring of Behavior for Physical Activity|BEHAVIORAL: Self-Monitoring of Behavior for Physical Activity|BEHAVIORAL: Self-Monitoring of Behavior for Mood|BEHAVIORAL: Action Planning for Mood
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Induction Chemotherapy Using Cyclophosphamide and Topotecan in Treating Patients Who Are Undergoing Autologous Peripheral Stem Cell Transplantation for Newly Diagnosed or Progressive Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: BIOLOGICAL: filgrastim|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: isotretinoin|DRUG: melphalan|DRUG: topotecan hydrochloride|DRUG: vincristine sulfate|PROCEDURE: conventional surgery|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pancreatic Islet Cell Transplantation After Kidney Transplantation - A Novel Approach to Immunosupression
Status: WITHDRAWN
Conditions: Islet Cell Transplantation|Type 1 Diabetes
Interventions: BIOLOGICAL: Islet cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correlation of Mesalamine Pharmacokinetics With Local Availability
Status: COMPLETED
Conditions: Local Drug Concentration in Gastrointestinal Tract
Interventions: DRUG: Pentasa 500 mg capsule x 2 with 240 mL water; single dose|DRUG: Apriso 375 mg capsule x 3 with 240 mL water; single dose|DRUG: Lialda 1200 mg tablet x 1 with 240 mL water; single dose|DRUG: Delzicol 100 mg mesalamine x 1 with 245 mL water; single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Surgical Management of Medication Related Osteonecrosis of the Jaws With Concentrated Growth Factor
Status: COMPLETED
Conditions: Healing Surgical Wounds|Infection
Interventions: PROCEDURE: Concentrated growth factor|PROCEDURE: Non-concentrated growth factor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Manual Therapy on Chronic Pain and Functionality of Breast Cancer Survivors
Status: TERMINATED
Conditions: Breast Cancer
Interventions: OTHER: Kinesiotherapy Protocol|OTHER: Manual Therapy Protocol|OTHER: Traditional Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tart Cherry, Metabolic Syndrome, and Cardiovascular Risk
Status: COMPLETED
Conditions: Metabolic Syndrome|Cardiovascular Diseases|Diabetes
Interventions: DIETARY_SUPPLEMENT: Tart Cherry|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Non-Surgical Treatment Options for Chronic Exertional Compartment Syndrome (CECS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Exertional Compartment Syndrome
Interventions: BEHAVIORAL: Supervised Gait Retraining|BEHAVIORAL: Home Based Gait Retraining|DRUG: Saline Injection|DRUG: Botulinum Toxin Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Blood Collection Study From COVID-19 Convalescents Previously Hospitalized to Identify Immunogenic Viral Epitopes
Status: COMPLETED
Conditions: Identify the Viral Epitopes of Memory CD8 T Cells From Individuals That Have Recovered From SARS-CoV-2 Infection|Determine Which SARS-CoV-2 Proteins Are Frequently Recognized by T Cells in Patients With Varying HLA Types
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized Study of Smile Exercise for Dry Eye
Status: COMPLETED
Conditions: Dry Eye|Keratoconjunctivitis Sicca|Eye Diseases|Corneal Diseases|Conjunctival Diseases
Interventions: BEHAVIORAL: smile exercise|DRUG: 0.1% sodium hyaluronate eye drop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Deferred Stenting in Patients With Anterior Wall STEMI
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myocardial Infarction With ST Elevation|Anterior Wall Myocardial Infarction
Interventions: PROCEDURE: Immediate stenting|PROCEDURE: Deferred stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abatacept for GVHD Prophylaxis After Hematopoietic Stem Cell Transplantation for Pediatric Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease|Graft Versus Host Disease
Interventions: DRUG: Diphenhydramine|DRUG: Acetaminophen|DRUG: Methylprednisolone|DRUG: Meperidine|DRUG: Alemtuzumab|DRUG: Thymoglobulin|DRUG: Fludarabine|DRUG: Melphalan|DRUG: Thiotepa|DRUG: Cyclosporine|DRUG: Tacrolimus|DRUG: Methotrexate|DRUG: Abatacept|PROCEDURE: Marrow infusion|DRUG: Sirolimus|DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Addition of Oscillatory Positive Expiratory Pressure (OPEP) Device to a Chest Physiotherapy Program Provide Further Health Benefits in Children With Bronchiectasis?
Status: COMPLETED
Conditions: Bronchiectasis
Interventions: OTHER: Chest physiotherapy|DEVICE: Oscillatory Positive Expiratory Pressure (OPEP) device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing Breast Cancer Therapy-related Cardiovascular Toxicity With a Daily-adapted Program With Mhealth Support
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer Female
Interventions: BEHAVIORAL: Individualised health recommentations|BEHAVIORAL: General health recommendations|BEHAVIORAL: Individualised physical exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-Up
Status: TERMINATED
Conditions: Cardiovascular Diseases|Carotid Artery Diseases|Intracranial Arteriosclerosis|Cerebrovascular Disorders|Heart Diseases|Vascular Diseases|Atherosclerosis
Interventions: DRUG: Vitamin E|DRUG: Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Effect of Administering Intravenous Magnesium Sulfate on Fetal Cardiotocography and Neonatal Outcome in Preeclamptic Patients
Status: UNKNOWN
Conditions: Preeclampsia
Interventions: DRUG: MgSO4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Arterial Stiffness and Calcifications in Haemodialysis Patients on Sevelamer or Calcium Acetate
Status: WITHDRAWN
Conditions: Haemodialyzed Patients|Hyperphosphatemia
Interventions: DRUG: Calcium acetate|DRUG: Sevelamer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I, Single IV Dose Of PF-04360365 In Adults With Mild To Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: BIOLOGICAL: PF-04360365|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial Evaluating the Role of Exercise in Women Undergoing Treatment for Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Metastatic Operable Breast Cancer
Interventions: OTHER: Yogic and routine exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: V5/MT Stimulation on Reading and Reading-related Measures in Developmental Dyslexia
Status: RECRUITING
Conditions: Developmental Dyslexia
Interventions: DEVICE: Active HD-tDCS over V5/MT|DEVICE: Active HD-tDCS over V1|DEVICE: Sham HD-tDCS over V5/MT or V1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Image-Guided Gynecologic Brachytherapy
Status: RECRUITING
Conditions: Cervical Cancer|Uterine Cancer|Vaginal Cancer|Vulvar Cancer|Bladder Cancer
Interventions: DEVICE: Image-Guided Brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anthocyanin-Rich Table Grape Powder for Prophylaxis of Post-Operative Atrial Fibrillation
Status: NOT_YET_RECRUITING
Conditions: Post-operative Atrial Fibrillation (POAF)
Interventions: DRUG: Freeze-Dried California Table Grape|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Superior Bilioenteric Anastomosis by Magnetic Compressive Technique
Status: UNKNOWN
Conditions: Hilar Cholangiocarcinoma|Bile Duct Injury|Choledochal Cyst|Biliary Calculi
Interventions: DEVICE: Magnetic Compressive Anastomosis|PROCEDURE: Manual Anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Sequential CD19 and CD22 Targeted CAR-T Therapy for Relapsed/Refractory B Cell Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Lymphoma, B-Cell
Interventions: BIOLOGICAL: CD19 and CD22 targeted CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Control of COPD Symptoms in Patients Treated With Tiotropium Bromide 18mcg Once Daily Alone, ADOAIR 50/250mcg Twice Daily Alone or ADOAIR 50/250mcg Plus Tiotropium Bromide 18mcg
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: fluticasone propionate/salmeterol 50/250mcg|DRUG: fluticasone propionate/salmeterol placebo|DRUG: tiotropium bromide 18mcg|DRUG: tiotropium bromide placebo|DRUG: fluticasone propionate/salmeterol 50/250mcg and tiotropium 18mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact on Reducing the Incidence of Low Serum Calcium by Providing Educational Materials on the Need to Take Daily Supplemental Calcium and Vitamin D to Patients With Paget's Disease Treated With Reclast®
Status: COMPLETED
Conditions: Paget's Disease of the Bone|Hypocalcemia
Interventions: DRUG: Reclast (ZOL446, zoledronic acid)|DIETARY_SUPPLEMENT: Calcium|DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Post-marketing Study Evaluating Eslicarbazepine Acetate (ESL) as Adjunctive Treatment in Partial-Onset Seizures (Study E2093-E044-404) (EPOS)
Status: COMPLETED
Conditions: Partial Onset Seizures
Interventions: DRUG: Eslicarbazepine Acetate tablets
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Staccato Loxapine in Migraine (Out Patient)
Status: COMPLETED
Conditions: Migraine Headache
Interventions: DRUG: Inhaled Placebo|DRUG: Inhaled Loxapine 1.25 mg|DRUG: Inhaled Loxapine 2.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intraocular Pressure With Loteprednol and Dexamethasone
Status: COMPLETED
Conditions: Glaucoma, Open-Angle|Ocular Hypertension
Interventions: DRUG: Loteprednol Etabonate 0.5%|DRUG: Dexamethasone 0.1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Vitamin E Incorporated Oat Supplementation in Metabolic Syndrome (MetS) Patients
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Vitamin E incorporated oat supplement|DIETARY_SUPPLEMENT: Oat supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Study of Two Hyaluronic Acid Formulation in the Management of Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Hymovis ONE|DEVICE: Monovisc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Safety of the Pulmonary Valved Conduit (PV-001) in Subjects Undergoing Right Ventricular Outflow Tract Reconstruction
Status: UNKNOWN
Conditions: Congenital Heart Disease
Interventions: DEVICE: Bioabsorbable Pulmonary Valved Conduit (PV-001)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Colchicine for the Palliative Management of Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Metastasis|Invasion
Interventions: DRUG: Colchicine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carboplatin, Paclitaxel, and Pegfilgrastim in Treating Patients With Stage III or Stage IV Ovarian Epithelial, Fallopian Tube, Primary Peritoneal, or Carcinosarcoma Cancer
Status: COMPLETED
Conditions: Fallopian Tube Carcinoma|Infectious Disorder|Neutropenia|Ovarian Carcinosarcoma|Primary Peritoneal Carcinoma|Stage III Ovarian Cancer|Stage IV Ovarian Cancer
Interventions: PROCEDURE: Adjuvant Therapy|DRUG: Carboplatin|DRUG: Paclitaxel|BIOLOGICAL: Pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Pulp Mesenchymal Stem Cells in the Treatment of Primary Mild to Moderate Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: Low Dose of Mesenchymal stem cell|BIOLOGICAL: High Dose of Mesenchymal stem cell|DRUG: Sodium Hyaluronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate Safety, Tolerability, and Immunogenicity of Adjuvanted HIV-1 Fusion Peptide Conjugate Vaccine Alone or in Prime-Boost Regimens With Adjuvanted HIV-1 Envelope Trimer 4571 and HIV-1 Trimer 6931 Vaccines in Healthy Adults
Status: COMPLETED
Conditions: HIV
Interventions: BIOLOGICAL: FP conjugate vaccine (25 mcg)|BIOLOGICAL: FP conjugate vaccine (200 mcg)|BIOLOGICAL: Trimer 6931 (100 mcg)|BIOLOGICAL: Trimer 6931 (200 mcg)|BIOLOGICAL: Trimer 4571 (200 mcg)|BIOLOGICAL: Trimer 4571 (100 mcg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Registry for Adolescent and Pediatric Participants Who Received a Gilead Hepatitis C Virus Direct Acting Antiviral (DAA) in Gilead-Sponsored Chronic Hepatitis C Infection Trials
Status: TERMINATED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: Sofosbuvir (SOF)|DRUG: Ledipasvir/Sofosbuvir (LDV/SOF)|DRUG: Sofosbuvir/Velpatasvir (SOF/VEL)|DRUG: Sofosbuvir/Velpatasvir/Voxilaprevir (SOF/VEL/VOX)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Chronic Myofascial Pain Syndrome Over Neck by Using Intravascular Laser Irradiation of Blood
Status: UNKNOWN
Conditions: Myofacial Pain Syndromes
Interventions: DEVICE: Intravascular laser irradiation of blood (ILIB)|DEVICE: Transcutaneous electrical nerve stimulation|OTHER: Stretching exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Confirmation and Dose Expansion Phase 1 Study of IO-108 and IO-108 + Anti-PD-1 in Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumor
Interventions: BIOLOGICAL: IO-108|BIOLOGICAL: IO-108 + pembrolizumab|BIOLOGICAL: IO-108 + tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cisplatin vs. Doxorubicin/Cyclophosphamide in BrCa
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Cisplatin|DRUG: Cyclophosphamide|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Pain Associated With Lumbosacral Radiculopathy in Adults
Status: COMPLETED
Conditions: Lumbosacral Radiculopathy
Interventions: COMBINATION_PRODUCT: Clonidine Micropellets|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: New Vital Pulpotomy Medications in Primary Molars
Status: ACTIVE_NOT_RECRUITING
Conditions: Carious Exposure of Pulp
Interventions: DRUG: Formocresol|DRUG: Biodentine|DRUG: Hyaluronic acid gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Unloader Bracing in Clinical Outcome and Cartilage Physiology Following Microfracture of Chondral Defects
Status: COMPLETED
Conditions: Cartilage Loss|Microfracture
Interventions: DEVICE: Unloader Bracing|DEVICE: Non-Bracing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Test of a Preventive Effect of a Deodorant Device Against Respiratory Infections
Status: UNKNOWN
Conditions: Respiratory Infection
Interventions: DEVICE: Cleverin Gel|DEVICE: Inactive Cleverin Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: MitoQ for Fatigue in Multiple Sclerosis
Status: TERMINATED
Conditions: Multiple Sclerosis|Fatigue
Interventions: DRUG: Mitoquinone|DRUG: Mitoquinone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Camrelizumab in Combination With Apatinib for Neoadjuvant Treatment of Early-stage TNBC With a High Proportion of TILs
Status: RECRUITING
Conditions: Breast Cancer|Triple-Negative Breast Cancer
Interventions: DRUG: Anti-PD-1 monoclonal antibody|DRUG: VEGFR2 Tyrosine Kinase Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab Versus Cidofovir for the Treatment of Recurrent Respiratory Papillomatosis
Status: UNKNOWN
Conditions: Recurrent Respiratory Papillomatosis
Interventions: DRUG: Bevacizumab|DRUG: Cidofovir|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Evaluation of Normothermic Perfusion Machine Preservation in Liver Transplant Using Very Old Donors
Status: UNKNOWN
Conditions: Ischemic Reperfusion Injury
Interventions: DEVICE: Normothermic machine perfusion|PROCEDURE: Static cold storage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture to Enhance for Pulmonary Rehab
Status: COMPLETED
Conditions: COPD
Interventions: DEVICE: Pulmonary rehabilitation program + EA Lung Mu-Shu+ St36|DEVICE: Pulmonary rehabilitation program + Lv7/Gb26
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT