pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Clofarabine and Low-dose Cytarabine Followed by Consolidation Therapy in AML Patients Age Greater Than or Equal to 60 Years
Status: TERMINATED
Conditions: Acute Myelogenous Leukemia
Interventions: DRUG: Clofarabine|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alisertib With or Without Fulvestrant in Treating Patients With Locally Advanced or Metastatic, Endocrine-Resistant Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Estrogen Receptor Status|HER2/Neu Negative|Invasive Breast Carcinoma|Postmenopausal|Stage III Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: Alisertib|DRUG: Fulvestrant|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2a Study Examining the Safety and Efficacy of BOL-DP-o-04 for Treating Diabetic Neuropathy
Status: TERMINATED
Conditions: Diabetic Neuropathy
Interventions: DRUG: BOL-DP-o-04|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Respiratory Muscle Training in Adults With Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Respiratory muscle training|DEVICE: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prebiotic Intervention for Autism Spectrum Disorders
Status: COMPLETED
Conditions: Autism
Interventions: DIETARY_SUPPLEMENT: B-GOS|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of SGN-ALPV in Advanced Solid Tumors
Status: TERMINATED
Conditions: Ovarian Neoplasms|Endometrial Neoplasms|Carcinoma, Non-Small-Cell Lung|Stomach Neoplasms|Gastroesophageal Junction Carcinoma|Uterine Cervical Neoplasms|Testicular Neoplasms
Interventions: DRUG: SGN-ALPV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety of Tegileridine and Oliceridine Injections in the Treatment of Postoperative Pain
Status: NOT_YET_RECRUITING
Conditions: Analgesia
Interventions: DRUG: Tegileridine|DRUG: Oliceridine|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of the Tumor Microenvironment of Pancreatic Cancer to Predict Treatment Outcome
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Gadobutrol|DRUG: [F-18]HX4|DRUG: Gemcitabine|RADIATION: Radiotherapy|PROCEDURE: Pancreaticoduodenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of the Safety, Tolerability, Pharmacokinetics of NIOCH-14 in Volunteers Aged 18-50 Years
Status: COMPLETED
Conditions: Smallpox|Monkeypox|Cowpox|Vaccinia Virus Infection
Interventions: DRUG: NIOCH-14, 200 mg capsule: 1 capsule (200 mg) of NIOCH-14 once orally|DRUG: NIOCH-14, 200 mg capsule: 3 capsules (200 mg each) of NIOCH-14 once orally. (Total 600 mg NIOCH-14 per day)|DRUG: NIOCH-14, 200 mg capsule: 6 capsules (200 mg each) of NIOCH-14 per day orally. (Total 1200 mg NIOCH-14 per day)|DRUG: NIOCH-14, 200 mg capsule: 1 capsule (200 mg) of NIOCH-14 a day orally for 6 days|DRUG: NIOCH-14, 200 mg capsule: 3 capsules (200 mg each) of NIOCH-14 a day orally for 6 days. (Total 600 mg NIOCH-14 per day for 6 days)|DRUG: NIOCH-14, 200 mg capsule: 3 capsules (200 mg each) of NIOCH-14 twice a day orally for 6 days. (Total 1200 mg NIOCH-14 per day for 6 days)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COMPARISON OF OUTCOMES OF BI-FLANGED METAL STENT ALONE VERSUS BI-FLANGED METAL STENT WITH CO-AXIAL PLASTIC STENT FOR DRAINAGE OF WALLED-OFF PANCREATIC NECROSIS - A PROSPECTIVE RANDOMISED CONTROLLED STUDY.
Status: COMPLETED
Conditions: ENDOSCOPIC ULTRASONOGRAPHY
Interventions: PROCEDURE: Endoscopic ultrasound guided drainage of walled off pancreatic necrosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy of Botulinum Toxin B (Myobloc) for the Treatment of Prosthesis-associated Sweating
Status: COMPLETED
Conditions: Hyperhidrosis
Interventions: DRUG: Botulinum Type B|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of INTORUS as a Therapeutic Tool in Motor Intervention in Patients at Aspace Centres in the Province of Cáceres
Status: COMPLETED
Conditions: Cerebral Palsy|Motor Disorders|Motor Activity
Interventions: DEVICE: INTORUS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Progesterone Primed Ovarian Stimulation Versus GnRH Antagonist in With Expected High Ovarian Response Undergoing in Vitro Fertilization
Status: NOT_YET_RECRUITING
Conditions: IVF|PCO
Interventions: DRUG: Dydrogesterone Tablets|DRUG: Cetrorelix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterisation of Uterine Fibroid Tissue Stiffness
Status: ENROLLING_BY_INVITATION
Conditions: Leiomyoma
Interventions: DEVICE: Supersonic Imagine Aixplorer SWE Ultrasound Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: At Home Early vs. Delayed Catheter Removal Following Failed Postoperative Voiding Trial: a Randomized Trial
Status: TERMINATED
Conditions: Urinary Retention Postoperative
Interventions: OTHER: Early urinary catheter removal|OTHER: Urinary catheter removal on POD 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: RecoveryPlus Telerehab Platform Pilot Study
Status: COMPLETED
Conditions: Heart Diseases|Angina, Stable|Angina Pectoris|Myocardial Ischemia|Myocardial Infarction|Coronary Artery Disease|Coronary Artery Stenosis|Valve Heart Disease|Valve Disease, Heart
Interventions: BEHAVIORAL: Cardiac Telerehabilitation (CTR) via the RecoveryPlus platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Postamputation Pain: Peripheral Mechanisms
Status: COMPLETED
Conditions: Neuropathic Pain|Amputation, Traumatic|Nerve Block|Phantom Limb Pain|Stump Pain
Interventions: DEVICE: Lidocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of MSC Intervention on the Dyadic Mental Health of Lung Cancer Patients and Their Caregivers
Status: COMPLETED
Conditions: Depression, Anxiety
Interventions: BEHAVIORAL: MSC intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: All on Six Versus Parallel Implant Distribution for Maxillary Denture Opposing Mandibular All on Four
Status: COMPLETED
Conditions: Peri-Implantitis|Occlusal Trauma|Implant Complication
Interventions: PROCEDURE: implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection
Status: RECRUITING
Conditions: Spontaneous Coronary Artery Dissection|Healthy
Interventions: OTHER: Arterial Tonometry|DIAGNOSTIC_TEST: Echocardiogram|DIAGNOSTIC_TEST: Carotid Ultrasounds|DIAGNOSTIC_TEST: Elastography|OTHER: Ankle-Brachial Index|OTHER: Microneurography with sympathoexcitatory maneuvers
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prinomastat Plus Temozolomide Following Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: prinomastat|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Treatment of Multifocal Lung Adenocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Neoplasms|Carcinoma Non-small-cell Lung|Adenocarcinoma
Interventions: GENETIC: Multifocal Lung Adenocarcinoma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplementation With L. Reuteri in H. Pylori Infected Adults
Status: UNKNOWN
Conditions: Dyspepsia|H. Pylori Infection
Interventions: DIETARY_SUPPLEMENT: L. reuteri|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Virtual Sun Safe Workplaces Ph II (SSW Works)
Status: ACTIVE_NOT_RECRUITING
Conditions: Skin Cancer|Occupational Exposure
Interventions: BEHAVIORAL: SSW Works|BEHAVIORAL: Minimal Information Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Effectiveness Between PL and PRP on Knee Osteoarthritis: a Prospective,Randomized,Placebo-controlled Trial
Status: UNKNOWN
Conditions: Osteoarthritis (OA) of the Knee
Interventions: OTHER: Saline injection|BIOLOGICAL: PRP injection|BIOLOGICAL: PL injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation After Ileo-anal Pouch Surgery
Status: RECRUITING
Conditions: Colonic Pouches|Physical Therapy Modalities|Biofeedback
Interventions: BEHAVIORAL: Pelvic floor and bowel behavioural training|OTHER: Standard arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Apixaban in Recent Acute Coronary Syndrome
Status: COMPLETED
Conditions: Acute Coronary Syndrome (ACS)
Interventions: DRUG: Apixaban|DRUG: Apixaban|DRUG: Placebo|DRUG: Apixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Behavior and Exercise Versus Drug Treatment in Men With Nocturia (BEDTiMe)
Status: COMPLETED
Conditions: Nocturia
Interventions: BEHAVIORAL: Behavioral|DRUG: tamsulosin (alpha-adrenergic antagonist medication)|DRUG: placebo|BEHAVIORAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Effectiveness of Selected Physical and Kinesiotherapeutic Methods in Patients With Lower Calcaneal Spur
Status: UNKNOWN
Conditions: Heel Spur|Calcaneal Spur
Interventions: DEVICE: Shock Master 300|DEVICE: Skanlab 25 BODYWAVE|DEVICE: EVO US13 CosmoGamma|DEVICE: Sham LASER CTL1106MX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vemurafenib and Cobimetinib Combination in BRAF Mutated Melanoma With Brain Metastasis
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: DRUG: Cobimetinib + Vemurafenib combination treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of YY-20394 in Patients With B Cell Hematologic Malignancies
Status: UNKNOWN
Conditions: B-cell Lymphoma Recurrent|B-cell Chronic Lymphocytic Leukemia
Interventions: DRUG: YY-20394
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surveillance of Influenza Virus Among Children With Febrile Respiratory Complaints Attending the Pediatric Clinic of the First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, Mainland China
Status: COMPLETED
Conditions: Influenza Type A|Influenza Type B
Interventions: OTHER: Nasopharyngeal Swab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Substance Use Treatment and Access to Resources (STARS) Project
Status: RECRUITING
Conditions: Substance Use Disorders|Pregnancy Related|Child Neglect
Interventions: BEHAVIORAL: STARS + maternal Attachment Biobehavioral Catchup home visiting model|BEHAVIORAL: STARs Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: High Resolution Optical Imaging of the Esophagus Using the NvisionVLE™ Imaging System
Status: COMPLETED
Conditions: Undergoing Esophagogastroduodenoscopy (EGD)
Interventions: DEVICE: NvisionVLE Imaging System: NvisionVLE Imaging Console, NvisionVLE Optical Probe and Inflation Accessory Kit
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Anti-PD-L1 in Combination With Chemo(Radio)Therapy for Resectable Esophageal Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Durvalumab|DRUG: Carboplatin|DRUG: Paclitaxel|RADIATION: Radiotherapy 23 x 1.8 Gy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First-line Trastuzumab, Gemcitabine, Cisplatin and Nivolumab in Advanced HER2- Positive Biliary Tract Cancer: a Multicenter, Open-label, Single-arm Phase Ib/II Trial (HERBOT)
Status: NOT_YET_RECRUITING
Conditions: HER2 Positive Advanced/Metastatic/Nonresectable Biliary Tract Cancer
Interventions: DRUG: Trastuzumab+Nivolumab+Gemcitabine+Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccination of AJCC Stage IIB, IIC, III and IV Melanoma Patients With Human and Mouse Tyrosinase DNA Vaccines
Status: COMPLETED
Conditions: Melanoma|Skin
Interventions: BIOLOGICAL: human tyrosinase|BIOLOGICAL: mouse tyrosinase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methylphenidate and Response to Alcohol Cues
Status: RECRUITING
Conditions: Alcohol Use Disorder|Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Methylphenidate Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 1/2a Study of Oral BAL101553 in Adult Patients With Solid Tumors or Glioblastoma or High-grade Glioma
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Lisavanbulin Phase 1 dose escalation portion|DRUG: Lisavanbulin Phase 2a expansion portion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Japanese Men to Test How Well Different Doses of BI 764198 Are Tolerated
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 764198|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-BCMA Chimeric Antigen Receptor T Cells for Relapsed or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Refractory Multiple Myeloma|Relapsed Multiple Myeloma
Interventions: BIOLOGICAL: Manufactured Anti-BCMA CAR-T cells|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Bioequivalence Test of DA-1229_01(A) at Fed State
Status: COMPLETED
Conditions: Type2 Diabetes
Interventions: DRUG: DA-1229_01(A), Sugamet SR Tab 5/1000mg®|DRUG: Sugamet SR Tab 5/1000mg®, DA-1229_01(A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Trial of ARQ 761 in Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: ARQ 761|DRUG: ARQ 761 Weekly Administration|DRUG: Bi-Weekly Administration of ARQ 761|DRUG: Two Consecutive Weeks Administration of ARQ 761 with one week of rest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Medacta International GMK Sphere Post-Marketing Surveillance Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Arthritis|Traumatic Arthritis|Rheumatoid Arthritis|Poly-arthritis|Avascular Necrosis
Interventions: DEVICE: GMK Sphere Knee Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Neoplasms
Interventions: DRUG: olaparib|BIOLOGICAL: durvalumab|DRUG: durvalumab placebo|DRUG: olaparib placebo|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of TCR-like CAR-T Cell Targeted MSLN in the Treatment of Ovarian Cancer
Status: RECRUITING
Conditions: Safety and Efficacy of TCR-like CAR-T
Interventions: BIOLOGICAL: TCR-like CAR-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Triweekly Cetuximab in Combination With Capecitabine as First-line Maintenance Treatment for KRAS/BRAF Wild-type Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Cetuximab|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualized Cefepime Dosing Study
Status: COMPLETED
Conditions: Antimicrobial Treatment
Interventions: DRUG: Cefepime dosing|OTHER: Blood sampling|OTHER: Urine sampling|OTHER: Determination of renal markers|OTHER: Population pharmacokinetic modeling|OTHER: Covariate screening|OTHER: Monte Carlo simulations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Adapted Formula on Atopic Dermatitis.
Status: ACTIVE_NOT_RECRUITING
Conditions: Atopic Dermatitis
Interventions: DIETARY_SUPPLEMENT: tested formula with fiber|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chronic Obstructive Pulmonary Disease (COPD) Nutrition Support Trial
Status: COMPLETED
Conditions: Malnutrition
Interventions: DIETARY_SUPPLEMENT: Oral Nutritional Supplements (Fortisip)|OTHER: Dietary Advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: THERMES ET VEINES: Spa for Prevention of Leg Ulcers
Status: COMPLETED
Conditions: Venous Insufficiency|Leg Ulcer|Varicose Ulcer
Interventions: DRUG: Immediate spa treatment|DRUG: Late spa treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Functional Outcomes of Critically Ill Patients With COVID-19
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome (ARDS)
Interventions: OTHER: ARDSNet table|OTHER: Driving Pressure|OTHER: Electrical Impedance Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of WBC on Patients With Metabolic or Neurological Diseases or Fibromyalgia (WBC-MeNeFi)
Status: RECRUITING
Conditions: Obesity|Fibromyalgia|Neurological Conditions
Interventions: OTHER: Whole-body cryostimulation (WBC)|OTHER: Rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Tinnitus Retraining Therapy on Subjective and Objective Measures of Chronic Tinnitus
Status: COMPLETED
Conditions: Tinnitus
Interventions: BEHAVIORAL: Tinnitus retraining therapy|DEVICE: Sound therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multivitamin Comparison Study in Kidney Transplant Recipients.
Status: COMPLETED
Conditions: Kidney Transplant Recipients
Interventions: DIETARY_SUPPLEMENT: Multivitamin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetic and Pharmacodynamic Study of FX006 in Patients With Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: FX006 10 mg|DRUG: FX006 40 mg|DRUG: FX006 60 mg|DRUG: TCA IR 40
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PK and PD of Single, Escalating Doses of PER977 Following Enoxaparin
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PER977|DRUG: Placebo|DRUG: enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Proof-of-Principle Study of TC-6499 in the Treatment of Constipation Predominant Irritable Bowel Syndrome (IBS)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: TC-6499|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aim to Reduce Movements in Tardive Dyskinesia
Status: COMPLETED
Conditions: Tardive Dyskinesia
Interventions: DRUG: SD-809|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study 3 Learning Verbs and Pronouns
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Addressed Speech|BEHAVIORAL: Overheard Speech
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: iC9-GD2-CAR-VZV-CTLs/Refractory or Metastatic GD2-positive Sarcoma and Neuroblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteosarcoma|Neuroblastoma
Interventions: GENETIC: GD2 T cells|BIOLOGICAL: VZV vaccine|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety And Pharmacokinetics Study Of PF-04287881 In Healthy Adults
Status: COMPLETED
Conditions: Respiratory Tract Infections
Interventions: DRUG: PF-04287881|DRUG: Placebo|DRUG: PF-04287881|DRUG: Placebo|DRUG: PF-04287881|DRUG: Placebo|DRUG: PF-04287881|DRUG: Placebo|DRUG: PF-04287881|DRUG: Placebo|DRUG: PF-04287881|DRUG: Placebo|DRUG: PF-04287881|DRUG: Placebo|DRUG: PF-04287881|DRUG: Placebo|DRUG: PF-04287881|DRUG: Placebo|DRUG: PF-04287881|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Radical Radiotherapy by External Beam Radiation Versus Radical Radiotherapy With Temporary Iridium Implant Plus External Beam Radiation in Carcinoma of the Prostate
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: Iridium Implant|RADIATION: Standard external beam irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Interventions During Living Kidney Donations
Status: RECRUITING
Conditions: Living-Kidney Donors
Interventions: DIETARY_SUPPLEMENT: Fasting mimicking diet|DIETARY_SUPPLEMENT: Ketogenic diet|DIETARY_SUPPLEMENT: Dietary restriction of sulfur containing amino acids|DIETARY_SUPPLEMENT: Control Group ( healthy, low-fat, moderate protein and high carbohydrate diet)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Oral Azacitidine in Transplant-Eligible Patients With Acute Myeloid Leukemia (AML) Suffering From Health-Inequality
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Oral Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Protein Ingestion on the Recovery of Skeletal Muscle Function Following Eccentric Exercise.
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Post exercise protein-polyphenol supplement|DIETARY_SUPPLEMENT: Post exercise placebo supplement|DIETARY_SUPPLEMENT: Pre bed protein-polyphenol supplement|DIETARY_SUPPLEMENT: Pre bed placebo supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Periodized Rehabilitation and Beta-alanine Supplementation in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: OTHER: Classic, progressive endurance training|OTHER: Periodized exercise training|DIETARY_SUPPLEMENT: beta-alanine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study in Healthy Volunteers to Compare the Profiles of DA-3880 and EU Sourced ARANESP® (Amgen)
Status: COMPLETED
Conditions: Symptomatic Anemia
Interventions: DRUG: DA3880|DRUG: Aranesp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of an Quadrivalent Influenza Virus Subunit Vaccine in Chinese Children Aged 6 to 35 Months
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Quadrivalent influenza virus subunit vaccine|BIOLOGICAL: Quadrivalent influenza virus subunit vaccine|BIOLOGICAL: Quadrivalent split influenza virus vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Nursing Care With Patients With Venous Leg Ulcers
Status: UNKNOWN
Conditions: - Venous Leg Ulcers
Interventions: BEHAVIORAL: Internet-based education of venous leg ulcer nursing care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effectiveness of Portable Electronic Vision Enhancement Systems (p-EVES) for Near Vision in Visual Impairment
Status: COMPLETED
Conditions: Moderate or Severe Vision Impairment, Both Eyes
Interventions: PROCEDURE: portable electronic magnifier|PROCEDURE: optical aids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) to Treat Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus - Poor Control
Interventions: PROCEDURE: Laparoscopic Roux en Y gastric Bypass
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Auranofin and Sirolimus in Treating Participants With Ovarian Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Serous Tumor|Recurrent Ovarian Carcinoma
Interventions: DRUG: Auranofin|OTHER: Laboratory Biomarker Analysis|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses of Inhaled AZD8683
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD8683|DRUG: Placebo to match
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: CB-839 + Capecitabine in Solid Tumors and Fluoropyrimidine Resistant PIK3CA Mutant Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer|Colon Cancer|Rectal Cancer|Solid Tumor
Interventions: DRUG: CB-839|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Device Study to Prevent Female Urinary Stress Incontinence
Status: COMPLETED
Conditions: Stress Incontinence, Female
Interventions: DEVICE: With Yoni.Fit|DEVICE: Without Yoni.Fit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Seroprevalence of Bordetella Pertussis Antibodies and Anti-pertussis Antibody Response After a Single Dose of Tdap in Pregnant Thai Women
Status: COMPLETED
Conditions: Pertussis|Pregnancy Related
Interventions: BIOLOGICAL: Tdap vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sorafenib With or Without Paclitaxel and Carboplatin in Treating Patients With Recurrent Ovarian Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer
Status: COMPLETED
Conditions: Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma
Interventions: DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Sorafenib Tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Value for Cord Blood Procalcitonin to Diagnose Early Neonatal Bacterial Infection
Status: COMPLETED
Conditions: Neonatal Bacterial Infection
Interventions: BIOLOGICAL: dosage of the umbilical cord blood Procalcitonin for diagnosing of IBNP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Trial of ALB 109564(a) in Subjects With Advanced Solid Tumors
Status: TERMINATED
Conditions: Cancer
Interventions: DRUG: ALB 109564(a) (12´-methylthiovinblastine dihydrochloride)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brachytherapy Radiation Directly to the Liver in Breast Cancer Patients With Metastatic to Liver
Status: TERMINATED
Conditions: Breast Cancer Metastatic to the Liver
Interventions: DEVICE: Brachytherapy|DEVICE: SIR-Sphere
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Interest of a Video-assisted Remote Speech Therapy Consultation in Patients With ORL Cancer (TELE ORTHOPHONIE)
Status: RECRUITING
Conditions: ORL Cancer
Interventions: OTHER: Patient managed at the IUCT-O and by a private speech therapist (near the patient's home).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Allogeneic Epstein Barr Virus-Specific Cytotoxic T-Lymphocytes in Treating Patients With Progressive, Relapsed, or Refractory Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: allogeneic Epstein-Barr virus-specific cytotoxic T lymphocytes|DRUG: fludarabine phosphate|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Trial to Assess the Safety and Efficacy of Sirolimus-Coated Balloon vs. Uncoated Standard Angioplasty for the Treatment of Below-the-knee Peripheral Arterial Disease
Status: RECRUITING
Conditions: Peripheral Artery Disease
Interventions: COMBINATION_PRODUCT: Percutaneous Transluminal Angioplasty (PTA) MagicTouch Sirolimus Coated PTA Balloon Catheter|DEVICE: Percutaneous Transluminal Angioplasty (PTA) with non-coated balloon catheter (POBA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-inflammatory Effects of Simvastatin
Status: TERMINATED
Conditions: Inflammation|Atherosclerosis|Hypercholesterolemia
Interventions: DRUG: Simvastatin 40mg|DRUG: Ezetimibe 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Diagnostic Study of Patients With Stage I Testicular Cancer
Status: COMPLETED
Conditions: Testicular Germ Cell Tumor
Interventions: OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|PROCEDURE: radionuclide imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: One-Day Acceptance and Commitment Training Intervention in Primary Care Patients
Status: COMPLETED
Conditions: Mood Disorders|Hypertension|Diabetes|Hypercholesterolemia
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy plus Illness Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Double-blind "Preferred" Vardenafil Dose Study of QoL and Functional Outcomes in Males With Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Levitra (Vardenafil, BAY38-9456)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel Plus Oxaliplatin as Therapy in Patients With Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreas Neoplasms
Interventions: DRUG: Docetaxel|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dynamic Optical Coherence Tomography(D-OCT) Aging Study: A Preliminary Evaluation of Structural Differences Between Young and Aged Skin, Cellulite and Atrophic Acne Scars in Female Caucasian Subjects With Fitzpatrick Skin Types I-III Utilizing Non-invasive in Vivo D-OCT.
Status: COMPLETED
Conditions: Skin Care
Interventions: DEVICE: Skin Imaging|OTHER: Facial Cleanser
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy Trial of Imexon Plus DTIC in Advanced Malignant Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: DRUG: imexon|DRUG: DTIC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase IIb Study of Glycopyrrolate Inhalation Solution Over 1 Week in Subjects With COPD
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Glycopyrrolate (85 μg)|DRUG: Glycopyrrolate (42.5 μg)|DRUG: Glycopyrrolate (14 μg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Definitive CCRT Combined With Durvalumab and Tremelimumab for Inoperable Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab in Treating Patients Who Have Undergone First-Line Therapy for Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: bevacizumab|OTHER: no maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Occupational Sitting in Type 2 Diabetes Using mHealth (Mobile Health)
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Patient-centered counselling and written material|BEHAVIORAL: mHealth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Development and Evaluation of a Culturally Tailored Support Group Program on the Psychosocial Wellbeing of Family Caregivers of Individuals Living With Dementia in Hong Kong
Status: UNKNOWN
Conditions: Dementia
Interventions: BEHAVIORAL: Cultivate yourself: support for caregivers of dementia persons
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Behavior of Various Galenic Forms of a Probiotic in the Digestive Tract.
Status: UNKNOWN
Conditions: Healthy Volunteer|Terminal Ileostomy
Interventions: DRUG: Lactobacillus salivarius BL 3123
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Malignant Ascites in Ovarian Cancer: Impact of Total Paracentesis on Hemodynamics
Status: COMPLETED
Conditions: Malignant Ascites|Ovarian Cancer|Hemodynamic Instability
Interventions: PROCEDURE: Paracentesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: State of Oxygen Metabolism, Cardiovascular and Respiratory System Reserve Capacity in Patients Who Underwent COVID-19
Status: RECRUITING
Conditions: Covid19|COVID19 Infection
Interventions: DIAGNOSTIC_TEST: Spirography and assessment of pulmonary diffusion capacity|DIAGNOSTIC_TEST: Cardiopulmonary stress test|DIAGNOSTIC_TEST: Computed tomography of the chest organs|DIAGNOSTIC_TEST: Heart echocardiography|OTHER: SF-36 Quality of Life Questionnaire|DIAGNOSTIC_TEST: Demographic and antropometric measures|OTHER: Indicators characterizing the severity of the underlying disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Calfactant for Direct Acute Respiratory Distress Syndrome
Status: TERMINATED
Conditions: Respiratory Distress Syndrome, Adult
Interventions: DRUG: Calfactant|DRUG: Room Air (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Insulin Detemir, Insulin Aspart and Biphasic Insulin Aspart 30 With OAD Treatment in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart|DRUG: insulin detemir|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metvix PDT Versus Vehicle PDT With Aktilite CL128 Lamp in Patients With Actinic Keratosis on the Face and Scalp
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: PROCEDURE: Photodynamic therapy with methyl aminolevulinate cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: D-serine Augmentation of Neuroplasticity
Status: COMPLETED
Conditions: Schizophrenia|Schizo Affective Disorder
Interventions: DRUG: D-serine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SHARE(D) Stage II: Alzheimer's Risk Disclosure Protocol Piloting
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Healthy Aging
Interventions: BEHAVIORAL: Personalized DAT Risk Disclosure Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: APA and Relaxation by Biofeedback in Patients With Haematological Malignancy Admitted in ICU
Status: RECRUITING
Conditions: Adapted Physical Activity|Hematological Malignancies|Anxiety|Relaxation
Interventions: BEHAVIORAL: Classical APA group:|BEHAVIORAL: APA with Exergaming device|BEHAVIORAL: APA associated with biofeedback relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluating the Effect of Nutritional Supplementation on Growth of Short and Lean Adolescents Girls
Status: RECRUITING
Conditions: Growth Problem|Low Weight
Interventions: DIETARY_SUPPLEMENT: Nutritional supplementation standardized formula|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fingolimod in Schizophrenia Patients
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Fingolimod|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Evaluation of Moxifloxacin IV to Enteral Switch Therapy in Intensive Care Patients
Status: COMPLETED
Conditions: Pneumonia
Interventions: DRUG: IV and enteral administration of moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ARQ 501 in Combination With Gemcitabine in Subjects With Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer|Adenocarcinoma
Interventions: DRUG: ARQ 501 in combination with gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of AMG 114 Administered by Subcutaneous Injection for the Treatment of Anemia in Subjects With Non-Myeloid Malignancies Receiving Multicycle Chemotherapy
Status: TERMINATED
Conditions: Anemia|Cancer
Interventions: DRUG: AMG 114
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Reactive Focal Mass Drug Administration (rfMDA) +/- Reactive Focal Vector Control (RAVC) in Namibia
Status: COMPLETED
Conditions: Malaria
Interventions: COMBINATION_PRODUCT: RACD|COMBINATION_PRODUCT: RAVC|COMBINATION_PRODUCT: rfMDA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Lung Assist Device in Acute Lung Impairment
Status: UNKNOWN
Conditions: Acute Respiratory Distress Syndrome
Interventions: PROCEDURE: iLA activve treatment|PROCEDURE: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Azacitidine and Arsenic Trioxide in Treating Patients With Myelodysplastic Syndromes
Status: TERMINATED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: arsenic trioxide|DRUG: azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Interaction Between the Antimalarial Combination Artemether/Lumefantrine and Combination Antiretroviral Therapy Including Lopinavir/Ritonavir in HIV-infected Adults
Status: COMPLETED
Conditions: HIV Infections|Malaria
Interventions: DRUG: Artemether/Lumefantrine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL])
Status: COMPLETED
Conditions: Nephrolithiasis|Urinary Tract Infections
Interventions: DRUG: nitrofurantoin monohydrate/macrocrystalline capsules|DRUG: ampicillin|DRUG: gentamicin|DRUG: vancomycin|DRUG: ceftriaxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Role of Endocannabinoids in Insulin Production and Action
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: Nabilone|DRUG: CP-945,598|OTHER: hyperglycemic clamp|OTHER: euglycemic-hyperinsulinemic clamp|OTHER: Nabilone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC