pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Repeat Dose Escalation Study to Investigate the Safety, Tolerability and Pharmacokinetics of GSK1322322 in Healthy Subjects
Status: COMPLETED
Conditions: Infections, Bacterial
Interventions: DRUG: GSK1322322/placebo|DRUG: GSK1322322/placebo and midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Effect of Filgotinib Dose De-escalation in Participants With Ulcerative Colitis (UC) in Remission
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: DRUG: Filgotinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dermatological Evaluation of Topic Compatibility-Dermacyd Tina Gel Tangerina Mix
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lactic acid (Dermacid)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Hydrolyzed Collagen and Vitamin C on Explosive Performance
Status: COMPLETED
Conditions: Collagen Synthesis|Rate of Force (RFD) Development
Interventions: DIETARY_SUPPLEMENT: Collagen and Vitamin C powder mix nutritional intervention|OTHER: Maltodextrin placebo powder|OTHER: Maximum power training exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Expanding (Gloving) Barrier Precautions for Reducing Clostridium Difficile Acquisition (and Infection) in VA
Status: ACTIVE_NOT_RECRUITING
Conditions: Clostridium Difficile
Interventions: OTHER: Universal gloving
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Telerehabilitation in Geriatric Patients at Aarhus University Hospital, Denmark
Status: WITHDRAWN
Conditions: Frail Elderly Syndrome
Interventions: OTHER: Telerehabilitation Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SNS to Increase HIV Testing Uptake and Linkage to Double Cascade Services Among Adolescent MSM and TGW in Thailand
Status: COMPLETED
Conditions: Social Network Strategy|HIV Self Testing|Men Who Have Sex With Men
Interventions: OTHER: Social network strategy (SNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Plate Fixation Versus Intramedullary Nailing of 3 and 4 Part Proximal Humerus Fractures
Status: ACTIVE_NOT_RECRUITING
Conditions: Shoulder Fractures|Humeral Fractures, Proximal
Interventions: PROCEDURE: Multiloc nail|PROCEDURE: Philos plate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MyOSA : Management and Treatment of Patients With Obstructive Sleep Apnea Syndrome(OSAS) Through a Telemedicine System
Status: COMPLETED
Conditions: Sleep Apnea Syndrome
Interventions: DEVICE: CPAP + Standard care|DEVICE: CPAP + Telemedicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sexual Maturation in β-Thalassemia Major Patients in Assiut University Hospital
Status: UNKNOWN
Conditions: β-Thalassemia Major Patients Receiving Chelation Therapy
Interventions: DIAGNOSTIC_TEST: FSH((Follicle Stimulating Hormone) and LH (Luteinizing Hormone) hormone for females and Testosterone hormone for males
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Intracameral Steroids During Phacoemulsification on the Cornea
Status: COMPLETED
Conditions: Corneal Edema
Interventions: OTHER: Control group|DRUG: Dexamethasone group|DRUG: Triamcinolone (TA) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Lóa Project: An Exploratory Pilot Randomised Controlled Trial of a Remotely-delivered Brief Cognitive Intervention to Reduce Intrusive Memories of Trauma for Women in Iceland
Status: COMPLETED
Conditions: Intrusive Memories of Traumatic Event(s)
Interventions: BEHAVIORAL: Brief, digitally delivered imagery-competing task intervention package, comprised of:|BEHAVIORAL: Brief, digitally delivered relaxation task intervention, comprised of:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Only IV Artesunate Versus IV Artesunate Plus IV Quinine in the Treatment of Severe Malaria in Children: A Comparative Study
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: IV Artesunate|DRUG: IV Quinine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Soy, Catfish, Anchovy, and Rice Supplementation Increases 25(OH)D Serum Levels in Tuberculosis Patients With Complications
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DIETARY_SUPPLEMENT: SCAR Porridge|OTHER: Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pedicle Screw Positioning With MySpine vs Free Hand Technique
Status: COMPLETED
Conditions: Spinal Deformity
Interventions: PROCEDURE: patient specific pedicle screw positioning guide|PROCEDURE: Free hand technique pedicle screw positioning|DEVICE: MUST pedicle screw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Co-administration of Olodaterol Respimat® and Tiotropium Handihaler®
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium|DRUG: Placebo matching Olodaterol|DRUG: Tiotropium|DRUG: Olodaterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lomitapide in Japanese Patients With HoFH on Concurrent Lipid-Lowering Therapy
Status: COMPLETED
Conditions: Familial Hypercholesterolemia - Homozygous
Interventions: DRUG: lomitapide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SUNDYS: A Multicenter, Randomized, Double-blind, Sham-controlled, Parallel-group Trial
Status: UNKNOWN
Conditions: Dystonia
Interventions: PROCEDURE: Deep brain stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Guselkumab in Participants With Active Psoriatic Arthritis and an Inadequate Response to Anti-Tumor Necrosis Factor Alpha (Anti-TNF Alpha) Therapy
Status: COMPLETED
Conditions: Arthritis, Psoriatic
Interventions: DRUG: Guselkumab 100 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Recombinant Anti-EGFR Monoclonal Antibody in Patients With Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: BIOLOGICAL: CPGJ602|BIOLOGICAL: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Collaborative Opioid Taper After Trauma: Preventing Opioid Misuse and Opioid Use Disorder
Status: UNKNOWN
Conditions: Opioid Use|Pain, Postoperative|Opioid Use, Unspecified|Trauma|Opioid-use Disorder
Interventions: OTHER: Provide assistance to subject's rural PCP pertaining to subject/patient pain management goals and opioid taper plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Remote Ischemic Preconditioning as a Method Against Subclinical Renal Injury and Contrast-induced Nephropathy
Status: COMPLETED
Conditions: Atherosclerosis|Stable Angina|Peripheral Artery Disease|Contrast-induced Nephropathy
Interventions: PROCEDURE: Remote ischemic preconditioning|PROCEDURE: SHAM Remote ischemic preconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Potential Pharmacokinetic Interaction of Perampanel With Oral Contraceptives in Healthy Female Subjects
Status: COMPLETED
Conditions: Partial Onset Epilepsy
Interventions: DRUG: Perampanel and Microgynon-30|DRUG: Perampanel and Microgynon-30
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect on Liver Fat and Metabolic Parameters When Switching a Protease Inhibitor or Efavirenz to Raltegravir
Status: COMPLETED
Conditions: HIV Seropositivity|Metabolic Syndrome|Fatty Liver
Interventions: DRUG: Raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Postoperative S-1-Based Chemoradiotherapy in Gastric Cancer
Status: UNKNOWN
Conditions: Stomach Neoplasms|Chemoradiotherapy, Adjuvant|Radiotherapy, Intensity-Modulated
Interventions: RADIATION: intensity-modulated radiotherapy|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Partial Versus Total Knee Replacement in Bicompartmental Gonarthrosis (Medial and Patellofemoral): Prospective Functional Assessment Study
Status: RECRUITING
Conditions: Knee Disease
Interventions: PROCEDURE: Prosthetic Surgical Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: International PPB/DICER1 Registry
Status: RECRUITING
Conditions: Pleuropulmonary Blastoma|Sertoli-Leydig Cell Tumor|DICER1 Syndrome|Cystic Nephroma|Wilms Tumor|Pineoblastoma|Renal Sarcoma|Nodular Hyperplasia of Thyroid|Nasal Chondromesenchymal Hamartoma|Ciliary Body Medulloepithelioma|Neuroblastoma|Pituitary Cancer|Embryonal Rhabdomyosarcoma|Ovarian Sarcoma|Gynandroblastoma|Thyroid Carcinoma|Embryonal Rhabdomyosarcoma of Vagina (Diagnosis)|Embryonal Rhabdomyosarcoma of Uterus (Diagnosis)|Embryonal Rhabdomyosarcoma of Cervix
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: VR-MARS Virtual Reality, Medical Assistance and Rescue for Space
Status: COMPLETED
Conditions: Instructional Virtual Realities|Weightlessness Simulation|Space Simulation|Patient Simulation|High Fidelity Simulation Training
Interventions: DEVICE: Augmented Reality Headset / Hololens 2 or Varjo XR3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A 4-year Extension Study to Core 1-year Study of Iron Chelation Therapy With Deferasirox in β-thalassemia Major Pediatric Patients With Transfusional Iron Overload.
Status: COMPLETED
Conditions: Transfusional Iron Overload|β-thalassemia Major|Pediatric Rare Anemia
Interventions: DRUG: Deferasirox
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Trial on Alleviation of Infant Malnutrition With Fortified Spread or Maize-Soy Flour Food Supplements
Status: COMPLETED
Conditions: Malnutrition
Interventions: DIETARY_SUPPLEMENT: Food supplement: fortified spread|DIETARY_SUPPLEMENT: Food supplement: maize-soy flour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stress-physiology Coherence, Interoception, and Well-being Following Mindfulness Training or Tracking Time Spent on Mobile Device
Status: COMPLETED
Conditions: Not Seeking to Treat Any Conditions
Interventions: BEHAVIORAL: Mindfulness training|BEHAVIORAL: Tracking time spent on mobile device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Sevoflurane and Desflurane on Heme Oxygenase-1 Expression in Elective Cholecystectomy
Status: NOT_YET_RECRUITING
Conditions: Cholecystitis, Chronic
Interventions: DRUG: Sevoflurane Group|DRUG: Desflurane Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety of FURESTEM-RA Inj. in Patients With Moderate to Severe Rheumatoid Arthritis(RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: FURESTEM-RA Inj.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Assess the Safety and Efficacy of Butterfly Medical Prostatic Retraction Device in BPH Patients.
Status: COMPLETED
Conditions: BPH|BOO - Bladder Outflow Obstruction
Interventions: PROCEDURE: Butterfly device implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bilateral Premolar Extraction vs Distalization: A Randomised Clinical Trial
Status: UNKNOWN
Conditions: Class II Division 1 Malocclusion
Interventions: PROCEDURE: MAXILLARY PREMOLAR EXTRACTION|PROCEDURE: DISTALIZATION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Concomitant Use of Nevirapine and Rifampicin With HIV-TB
Status: COMPLETED
Conditions: HIV/TB Co-infection
Interventions: DRUG: Nevirapine|DRUG: Efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Repeat Dosing of OROS® Methylphenidate Hydrochloride (CONCERTA®) and Immediate Release Methylphenidate Hydrochloride in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: OROS-Methylphenidate|DRUG: Immediate Release Methylphenidate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Indocyanine Green and Near-infrared Fluorescence Imaging to Detect Sentinel Lymph Nodes in Patients With Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Cancer|Sentinel Lymph Node Detection
Interventions: PROCEDURE: ICG Dye
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Microwave Ablation-Assisted Enucleation and Conventional Laparoscopic Partial Nephrectomy in the Treatment of T1a Renal Cell Carcinoma
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: PROCEDURE: laparoscopic microwave ablation-assisted enucleation|PROCEDURE: conventional laparoscopic partial nephrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test How Avenciguat (BI 685509) is Taken up in the Body of People With and Without Liver Problems
Status: RECRUITING
Conditions: Healthy|Liver Diseases
Interventions: DRUG: Avenciguat (BI 685509)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcome of Laser or Debrider Tonsillotomy Versus Tonsillectomy in Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: PROCEDURE: Tonsillectomy, laser tonsillotomy, debrider tonsillotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Lacrimal Drainage Obstruction Diseases Using Dacryoendoscopy
Status: COMPLETED
Conditions: Lacrimal Duct Obstruction
Interventions: PROCEDURE: Dacryoendoscopic-assisted laser dacryoplasty with silicone intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Doses of Tomato Lycopene on Blood Pressure in Pre-hypertensive Otherwise Healthy Subjects
Status: TERMINATED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Lyc-O-Mato 5mg|DIETARY_SUPPLEMENT: Lyc-O-Mato 15mg|DIETARY_SUPPLEMENT: Lyc-O-Mato 30mg|DIETARY_SUPPLEMENT: Lycopene capsules (non Lyc-o-mato) 15 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BeatPark: Self-rehabilitation in Walking With Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease|Walking, Difficulty
Interventions: DEVICE: BeatPark Application|OTHER: BeatPark Application without synchronized music|OTHER: BeatPark Application without music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Zidovudine Levels in HIV Infected Patients Being Treated for HCV
Status: COMPLETED
Conditions: HIV Infections|Hepatitis C
Interventions: DRUG: Ribavirin plus interferon alfa-2b|DRUG: Ribavirin|DRUG: Peginterferon alfa-2b
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Local Anesthesia on Control of Intraoperative Physiologic Parameters and Post Operative Comfort
Status: COMPLETED
Conditions: Pain, Procedural
Interventions: DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ExAblate Transcranial MR Guided Focused Ultrasound in the Treatment of Essential Tremor
Status: COMPLETED
Conditions: Essential Tremor
Interventions: DEVICE: ExAblate Transcranial MRgFUS System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propofol vs Propofol + Benzo/Opiates in High Risk Group
Status: TERMINATED
Conditions: Sleep Apnea, Obstructive|Obesity
Interventions: DRUG: Propofol Alone|DRUG: Propofol+Benzo/Opioids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Melatonin Supports Non Surgical Periodontal Treatment in Patients With Type 2 Diabetes and Periodontitis
Status: COMPLETED
Conditions: Diabetes Mellitus|Periodontitis|Melatonin|Matrix Metalloproteinases
Interventions: DRUG: Melatonin 3 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Two Week Dosing Study to Determine the Safety and Antiviral Activity of LCQ908 in Hepatitis C Patients
Status: TERMINATED
Conditions: Hepatitis C
Interventions: DRUG: LCQ908|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of 2 Strategies of Adjustment of Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome|Acute Lung Injury
Interventions: DEVICE: Setting of positive end-expiratory pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center Study of Lapatinib in Patients With Trastuzumab-refractory Metastatic Breast Cancer
Status: COMPLETED
Conditions: HER2 Positive Breast Cancer
Interventions: DRUG: lapatinib and capecitabine or vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rescue Quadratus Lumborum Blocks for Post-cesarean Pain
Status: WITHDRAWN
Conditions: Morphine|Analgesics|Analgesics, Opioid|Peripheral Nervous System Agents
Interventions: DRUG: Saline|DRUG: Bupivacaine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of GensSci098 in Subjects With Active Thyroid Eye Disease
Status: NOT_YET_RECRUITING
Conditions: Safety|Tolerability|GenSci098|Thyroid Eye Disease (TED)
Interventions: DRUG: GenSci098|DRUG: GenSci098 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Age-Related Macular Degeneration With Anecortave Acetate
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: Anecortave Acetate Sterile Suspension (15 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-Erythrocyte Dexamethasone Sodium Phosphate in Ataxia Teleangiectasia Patients
Status: COMPLETED
Conditions: Nervous System Disorder|Genetic Syndrome
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measuring Blood Flow in Heart Vessels With a New Fibre Optic Sensor
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Stenosis|Coronary Microvascular Disease
Interventions: DEVICE: Intra coronary rapid-exchange iKOs microcatheter intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Monotherapy Study to Evaluate the Efficacy and Safety of 2 Dose Levels of Albiglutide in Japanese Subjects With Type 2 Diabetes Mellitus (T2DM)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Albiglutide 30 mg weekly|DRUG: Albiglutide 50 mg weekly|DRUG: Placebo|DRUG: Liraglutide 0.9 mg daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Infant Male Circumcision in Gaborone, Botswana, and Surrounding Areas: Feasibility, Safety and Acceptability
Status: COMPLETED
Conditions: HIV Infections|Circumcision
Interventions: PROCEDURE: Circumcision|DEVICE: Mogen Clamp|DEVICE: Plastibell|DEVICE: AccuCirc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: T CELL THERAPY OPPOSING NOVEL COVID-19 INFECTION IN IMMUNOCOMPROMISED PATIENTS
Status: RECRUITING
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: Coronavirus-specific T cell (CST)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Observation of the Effect of Vitamin D Supplementation on Chronic Course of Patients With Ulcerative Colitis Based on Vitamin D Receptor Fok I Gene Polymorphism
Status: UNKNOWN
Conditions: Ulcerative Colitis|Vitamin D Deficiency|Vitamin D Supplement
Interventions: DRUG: Vitamin D drops
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stellate Ganglion Block for Preserving Arteriovenous Fistula in Hemodialysis Patients Undergoing Major Lower Limb Orthopedic Surgery
Status: RECRUITING
Conditions: Stellate Ganglion Block|Arteriovenous Fistula|Hemodialysis|Major Lower Limb Orthopedic Surgery
Interventions: DRUG: Stellate ganglion block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of BP1002 in Patients With Advanced Lymphoid Malignancies
Status: RECRUITING
Conditions: Mantle Cell Lymphoma|Peripheral T-cell Lymphoma (PTCL)|Cutaneous T-cell Lymphoma (CTCL)|Chronic Lymphocytic Leukemia (CLL)|Small Lymphocytic Lymphoma (SLL)|Follicular Lymphoma|Marginal Zone Lymphoma|Hodgkin Lymphoma|Waldenstrom Macroglobulinemia|DLBCL
Interventions: DRUG: L-Bcl-2 antisense oligonucleotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Hypovitaminosis D in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Hypovitaminosis D
Interventions: DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing 13-valent Pneumococcal Conjugate Vaccine With 7-valent Pneumococcal Conjugate Vaccine
Status: COMPLETED
Conditions: Vaccines, Pneumococcal
Interventions: BIOLOGICAL: 13 valent pneumococcal conjugate vaccine|BIOLOGICAL: 7vPnc pneumococcal conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Deep Bite Correction Using Auxiliary Intrusion Cantilevers With Initial Archwires in Adolescents
Status: COMPLETED
Conditions: Deep Overbite
Interventions: DEVICE: Auxiliary cantilever intrusion arches on initial archwires|DEVICE: Routine leveling and alignment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Transplantation in the Elderly - nEverOld Study
Status: UNKNOWN
Conditions: Chronic Renal Failure (CRF)|Graft Failure|Transplant; Failure, Kidney|Renal Transplant Rejection
Interventions: DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supraclavicular Versus Axillary Block for Arteriovenous (AV) Fistula Creation
Status: RECRUITING
Conditions: Arteriovenous Fistula|Brachial Plexus Block|Clinical Efficacy
Interventions: PROCEDURE: Supraclavicular block|PROCEDURE: Axillary block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sternal Closure With Biologic Bone Cement in Patients Undergoing Coronary Artery Bypass Grafting (CABG)
Status: UNKNOWN
Conditions: Sternal Closure
Interventions: DEVICE: Kryptonite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Electrical Stimulation (NMES) Treatment Technique Therapy in the Management of Young Infants With Severe Dysphagia
Status: COMPLETED
Conditions: Dysphagia
Interventions: DEVICE: Neuromuscular electrical stimulation (NMES)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Global Postural Re-Education And Neck Isometric Exercises In Cervical Radiculopathy RADICULOPATHY
Status: RECRUITING
Conditions: Cervical Radiculopathy
Interventions: OTHER: Neck Isometrics Exercises|OTHER: Global Posture Re-Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Virtual Reality Glasses During Anesthesia in Behavior, Anxiety and Pain Perception of Children
Status: UNKNOWN
Conditions: Pain
Interventions: DEVICE: Glasses|BEHAVIORAL: Distraction techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Promoting Self-management Behaviors in Adolescents With Type 1 Diabetes, Using Digital Storytelling
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Self-Management
Interventions: BEHAVIORAL: Digital storytelling training|BEHAVIORAL: Routine training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability, Immunogenicity and Protective Efficacy of PfSPZ Vaccine and PfSPZ-CVac in Indonesian Adults Against Naturally-Transmitted Malaria
Status: RECRUITING
Conditions: Malaria
Interventions: BIOLOGICAL: PfSPZ Vaccine|BIOLOGICAL: PfSPZ Challenge under chloroquine (CQ) chemoprophylaxis|OTHER: Normal Saline|DRUG: Chloroquine chemoprophylaxis alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessing Long-term CTN 0049 Outcomes, HCV Prevalence and Progression Along the HCV Care Continuum Among HIV/HCV Co-infected Substance Users in the U.S.
Status: COMPLETED
Conditions: Hepatitis C|HIV|AIDS|Substance Use
Interventions: OTHER: Control Group|BEHAVIORAL: Care Facilitation Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of R935788 in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia (AIHA)
Status: COMPLETED
Conditions: Warm Antibody Autoimmune Hemolytic Anemia
Interventions: DRUG: Fostamatinib 150 mg bid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive Disorder
Status: RECRUITING
Conditions: Adjunctive Treatment of Major Depressive Disorder (MDD)
Interventions: DRUG: CLE-100|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Acupuncture and Care Interventions for the Treatment of Breast Inflammation During Breastfeeding
Status: COMPLETED
Conditions: Mastitis
Interventions: PROCEDURE: Acupuncture treatment|PROCEDURE: Administration of oxytocin nasal spray|PROCEDURE: Improved breast milk removal|PROCEDURE: Warmth applied to breasts|PROCEDURE: Breast massage|DRUG: Anti-pyretic medication, paracetamol|DRUG: cefadroxil|DRUG: penicillin|DRUG: flucloxacillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRostate Evaluation for Clinically Important Disease: MRI vs Standard Evaluation Procedures
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: PROCEDURE: Standard of Care|PROCEDURE: MRI|PROCEDURE: MRI Targeted Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cells Transplantation in Patients With Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Type 2 Diabetes|Mesenchymal Stem Cells
Interventions: BIOLOGICAL: Umbilical Cord Mesenchymal Stem Cells|BIOLOGICAL: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Preoperative Oral Branched-chain Amino Acids on Reducing Postoperative Insulin Resistance.
Status: RECRUITING
Conditions: Insulin Resistance|Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: BCAA|DIETARY_SUPPLEMENT: water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of UCPVax Vaccine and Atezolizumab for the Treatment of Human Papillomavirus Positive Cancers (VolATIL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Squamous Cell Carcinoma of the Head and Neck|Anal Canal Cancer|Cervical Cancer
Interventions: BIOLOGICAL: Blood sample collection|PROCEDURE: Tumor biopsies|OTHER: CT scan|DRUG: Atezolizumab|DRUG: UCPVax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Cutaneous Sensory Blockade Between Single and Triple Injection of Intertransverse Process Block in Video Assisted Thoracoscopic Surgery Guided Single and Triple Injections of Intertransverse Process Block in Patients Undergoing Video Assisted Thoracoscopic Surgery
Status: NOT_YET_RECRUITING
Conditions: Intertransverse Process Block|Video Assisted Thoracic Surgery
Interventions: OTHER: Intertransverse process block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Peresolimab (LY3462817) in Participants With Moderately-to-Severely Active Rheumatoid Arthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Rheumatoid Arthritis|Arthritis|Joint Diseases|Musculoskeletal Diseases|Rheumatic Diseases|Connective Tissue Diseases|Autoimmune Diseases|Immune System Diseases
Interventions: DRUG: Peresolimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of HTX-011 for Postoperative Analgesia Following Abdominoplasty Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: HTX-011B|DRUG: Placebo|DRUG: HTX-011A|DRUG: HTX-002|DRUG: Bupivicaine HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Assessment of Visual Field-related Endpoints in Patients With Non-arteritic Ischemic Optic Neuropathy
Status: COMPLETED
Conditions: Non-arteritic Ischemic Optic Neuropathy
Interventions: DEVICE: perimetry|OTHER: D-BCVA|OTHER: RAPD|DEVICE: IOP|DEVICE: Spectralis OCT|OTHER: Fundus photography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of RC48-ADC Combined With JS001 For Postoperative Adjuvant Treatment of Upper Tract Urothelial Carcinoma
Status: RECRUITING
Conditions: Carcinoma|Upper Tract Urothelial Carcinoma|UTUC
Interventions: DRUG: RC48-ADC and JS001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility Study of Autologous Engineered Urethral Constructs for the Treatment of Strictures
Status: NOT_YET_RECRUITING
Conditions: Urologic Diseases|Male Urogenital Diseases|Urethral Stricture|Urethral Injury
Interventions: BIOLOGICAL: Autologous Engineered Urethral Construct
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate OrienX010 in Combination With JS001 in the Treatment of Stage IV (M1c) Liver Metastasis From Melanoma
Status: UNKNOWN
Conditions: Melanoma
Interventions: BIOLOGICAL: OrienX010 combination with JS001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Safety Study of ALRN-5281 in Healthy Subjects
Status: COMPLETED
Conditions: Growth Hormone Deficiency
Interventions: DRUG: ALRN-5281 0.015 mg/kg|DRUG: ALRN-5281 0.05 mg/kg|DRUG: ALRN-5281 0.15 mg/kg|DRUG: Placebo 0.015 mg/kg|DRUG: Placebo 0.05mg/kg|DRUG: Placebo 0.15mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Game Based Exercise Training on Balance and Postural Control in Patients With Ataxia
Status: COMPLETED
Conditions: Ataxia
Interventions: OTHER: Kinect + Exercise Training|OTHER: Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploring the Immune Response to SARS-CoV-2 COVID-19 Vaccines in Patients With Relapsing Multiple Sclerosis (RMS) Treated With Ofatumumab
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Comparison of Two Daily Disposable Silicone Hydrogel Soft Contact Lens
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Si-Hy (olifilcon B)|DEVICE: Vistakon (narafilcon A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial Comparing Infliximab and Infliximab and Azathioprine in the Treatment of Patients With Crohn's Disease na�ve to Both Immunomodulators and Biologic Therapy (Study of Biologic and Immunomodulator Naive Patients in Chrohn's Disease: SONIC
Status: COMPLETED
Conditions: Crohn Disease
Interventions: BIOLOGICAL: infliximab infusion; AZA placebo caps|OTHER: infliximab (IFX) infusion; azathioprine (AZA) caps|DRUG: infliximab (IFX) placebo infusion; azathioprine (AZA) caps
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VascuFit: Exercise and Vascular Aging
Status: COMPLETED
Conditions: Endothelial Function|Aerobic Exercise|Middle-aged Adults Sedentary, Elevated CV-risk)
Interventions: OTHER: non-linear periodized exercise (NLPE)|OTHER: Exercise counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Minimal Surgical Treatment for Obstructive Sleep Apnea (OSA)
Status: UNKNOWN
Conditions: Sleep Apnea Syndromes, Obstructive
Interventions: PROCEDURE: Minimally invasive, in-office, RF reduction of the affected area
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laryngeal Mask Airway Supreme Versus the Tracheal Tube as an Airway Device in Elective Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Cholecystitis|Choledocholithiasis
Interventions: DEVICE: Laryngeal Mask Airway-Supreme|DEVICE: Endotracheal Tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Multicomponent Program on a Group of Nonagenarians
Status: UNKNOWN
Conditions: Quality of Life|Healthy|Aging|Physical Activity
Interventions: OTHER: A multicomponent intervention program was developed consisting of two 60-minute sessions per week, held on non-consecutive days, for a period of 8 months.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Analysis of Imaging Features From Patients Treated With Brolucizumab in the Post-marketing Setting With Reports of Retinal Vasculitis and/or Retinal Vascular Occlusion
Status: COMPLETED
Conditions: Intraocular Inflammation|Retinal Vascular Occlusion
Interventions: OTHER: Brolucizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enteral Omega 3 During Radiotherapy to Improve the Quality of Life and Functionality of Head and Neck Cancer Patients
Status: TERMINATED
Conditions: Head and Neck Squamous Cell Carcinoma|Quality of Life|Radiotherapy; Complications
Interventions: DIETARY_SUPPLEMENT: Omega 3 Group|DIETARY_SUPPLEMENT: Placebo or Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Newer Versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) Trial
Status: COMPLETED
Conditions: Blood Pressure
Interventions: DRUG: amlodipine 5/10 mg per day plus valsartan 160 mg/day|DRUG: hydrochlorothiazide 6.25 mg/day plus bisoprolol 5/10 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention Study: Genetic Risk Communication and Wearables
Status: UNKNOWN
Conditions: Fitness Trackers|Sedentary Behavior|Exercise|Genetic Predisposition to Disease|Type 2 Diabetes
Interventions: GENETIC: Genetic Risk Estimate|OTHER: Genetic Risk Estimate + Fitbit Functions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Evaluating the Pharmacokinetics of Ceftobiprole When Taken by Obese Patients
Status: COMPLETED
Conditions: Obesity|Staphylococcal Skin Infections|Streptococcal Infections
Interventions: DRUG: Ceftobiprole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 2a Study, Effect of Vancomycin With vs Without Delpazolid (LCB01-0371) in Patients With MRSA Bacteremia
Status: TERMINATED
Conditions: MRSA Bacteremia
Interventions: DRUG: Delpazolid|DRUG: Vancomycin|DRUG: Placebo of Delpazolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib Study of MEK162 Plus BYL719 in Adult Patients With Selected Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced and Selected Solid Tumors|AML|High Risk and Very High Risk MDS
Interventions: DRUG: BYL719|DRUG: MEK162
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects With Decompensated Cirrhosis With Ascites
Status: COMPLETED
Conditions: Cirrhosis of the Liver|Ascites|Spontaneous Bacterial Peritonitis
Interventions: OTHER: Medical food, EnteraGam (Serum-Derived Bovine Immunoglobulin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Open-Label Drug-Drug Interaction Study of Telotristat Etiprate and Fexofenadine in Healthy Subjects
Status: COMPLETED
Conditions: Drug Interactions
Interventions: DRUG: Fexofenadine|DRUG: Telotristat etiprate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Clinical Study to Evaluate the Efficacy and Safety of HLX07 Combination Therapy or Monotherapy in Patients With Advanced ESCC
Status: RECRUITING
Conditions: ESCC or Esophageal Adenosquamous Carcinoma
Interventions: DRUG: HLX07+HLX10+ Cisplatin+5-FU|DRUG: HLX07
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalency Study of Mycophenolate Mofetil 500 mg Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Prophylaxis of Organ Rejection
Interventions: DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Instructions in Nitrous Oxide Effects and Choice - 10
Status: COMPLETED
Conditions: Opioid-Related Disorders|Substance-Related Disorders
Interventions: DRUG: Nitrous oxide 10% & placebo|DRUG: Nitrous oxide 20% & placebo|DRUG: Nitrous oxide 30% & placebo|DRUG: Nitrous oxide 40% and placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of SAGE-718 Oral Solution in Patients With Huntington's Disease - Part B
Status: COMPLETED
Conditions: Huntington Disease
Interventions: DRUG: SAGE-718
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oculusgen (Ologen) Glaucoma MMC Control in Estonia
Status: COMPLETED
Conditions: Open Angle Glaucoma|Angle Closure Glaucoma|Uveitis Glaucoma|Young Age Glaucoma|Neovascular Glaucoma|High Risk Patient
Interventions: DEVICE: ologen (oculusgen) collagen matrix|DRUG: MMC in Trabeculectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block vs Paravertebral Block for Pain Management in Fractured Ribs
Status: UNKNOWN
Conditions: Rib Fracture Multiple
Interventions: PROCEDURE: Erector Spinae Plane Block|PROCEDURE: Paravertebral Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cabozantinib-s-malate or Sunitinib Malate in Treating Patients With Previously Untreated Locally Advanced or Metastatic Kidney Cancer
Status: COMPLETED
Conditions: Clear Cell Renal Cell Carcinoma|Metastatic Kidney Carcinoma|Stage III Renal Cell Cancer AJCC v7|Stage IV Renal Cell Cancer AJCC v7
Interventions: DRUG: Cabozantinib S-malate|OTHER: Laboratory Biomarker Analysis|DRUG: Sunitinib Malate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Toxicity of Perirenal Fat in Overweight or Obese Subjects: A Pathophysiological Link Between Uric Acid Stones and Renal Ammonium Formation
Status: COMPLETED
Conditions: Uric Acid Stones
Interventions: OTHER: acid load test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER