pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Targeted Pathway Inhibition in Patients With Pancreatic Cancer
Status: RECRUITING
Conditions: Locally Advanced Pancreatic Ductal Adenocarcinoma|Metastatic Pancreatic Ductal Adenocarcinoma|Stage II Pancreatic Cancer AJCC v8|Stage III Pancreatic Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8|Unresectable Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: Cobimetinib|DRUG: Olaparib|DRUG: Onvansertib|DRUG: Azenosertib|DRUG: Saruparib|BIOLOGICAL: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of "Imaginative Distention", a Self Managed Tool to Cope With Fatigue,Insomnia and Stress in pw Insomnia and pw MS
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: "Imaginative Distention" technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antiplatelet Thrombolysin (Anfibatide) Phase 1 Clinical Trial in Healthy Volunteers
Status: SUSPENDED
Conditions: Antiplatelet Drug
Interventions: DRUG: Anfibatide 5 IU/60kg|DRUG: Anfibatide 5 IU/60kg +0.002 IU/kg/h|DRUG: Anfibatide 5 IU/60kg +0.004 IU/kg/h|DRUG: Anfibatide 5 IU/60kg +0.008 IU/kg/h|DRUG: Anfibatide 7 IU/60kg|DRUG: Anfibatide 7 IU/60kg +0.002 IU/kg/h|DRUG: Anfibatide 7 IU/60kg +0.004 IU/kg/h|DRUG: Anfibatide 7 IU/60kg +0.008 IU/kg/h
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Chewing Gum on Nausea, Vomiting and Bowel Function After Colorectal Surgery
Status: COMPLETED
Conditions: Postsurgical Ileus
Interventions: OTHER: gum chewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Three-year Follow-up of Participants After Administration of Boceprevir or Narlaprevir for the Treatment of Chronic Hepatitis C (P05063)
Status: TERMINATED
Conditions: Hepatitis C, Chronic|Hepacivirus
Interventions: BIOLOGICAL: Boceprevir|BIOLOGICAL: Narlaprevir|BIOLOGICAL: Peginterferon alfa-2b|DRUG: Ribavirin|OTHER: Blood/Plasma Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: For Nasotracheal Intubation With Video Rigid Stylet, Which Nostril is Better?
Status: COMPLETED
Conditions: Intubation|Video Rigid Stylet
Interventions: DEVICE: Video rigid stylet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Intra-abdominal Pressure and Insufflator Effects in Robotic Surgery
Status: COMPLETED
Conditions: Post Operative Pain|Hemodynamic Instability|Hypercapnia|Complication,Postoperative|Intraoperative Complications
Interventions: DEVICE: Valveless Insufflator with 12 mmHg intra-abdominal pressure|DEVICE: Valveless Insufflator with 8 mmHg intra-abdominal pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Disrupting the Bone Marrow Microenvironment With G-CSF in Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Precursor Cell Lymphoblastic Leukemia-Lymphoma
Interventions: DRUG: G-CSF|DRUG: Ifosfamide|DRUG: Etoposide|DRUG: Dexamethasone|DRUG: Mesna
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Postoperative Analgesia Between Intravenous Paracetamol and Intranasal Tapentadol
Status: COMPLETED
Conditions: Lower Limb Fracture
Interventions: DRUG: Tapentadol Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Study of Optical 3D Navigated Repetitive Transcranial Magnetic Stimulation for Achalasia.
Status: NOT_YET_RECRUITING
Conditions: Esophageal Achalasia|Transcranial Magnetic Stimulation, Repetitive|Vagus Nerve Motor Disorder|Functional Magnetic Resonance Imaging
Interventions: DEVICE: Repetitive transcranial magnetic stimulation|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of CIN-107 on the Pharmacokinetics of the MATE Substrate, Metformin, in Healthy Subjects
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Metformin|DRUG: CIN-107
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of the Efficacy and Safety of Disitamab Vedotin in Combination With Radiotherapy for the Adjuvant Treatment of HER2 Overexpressing UTUC Patients With High Risk Factors for Recurrence After Radical Surgery
Status: NOT_YET_RECRUITING
Conditions: Upper Urinary Tract Urothelial Carcinoma
Interventions: DRUG: Disitamab Vedotin|RADIATION: Radiotherapy|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Escalating Doses of ASP1235 (AGS62P1) Given as Monotherapy in Subjects With Acute Myeloid Leukemia (AML)
Status: TERMINATED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: ASP1235
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary Fascial Closure With Laparoscopic Ventral Hernia Repair: A Randomized Controlled Trial
Status: UNKNOWN
Conditions: Hernia, Ventral
Interventions: PROCEDURE: LVHR PFC|PROCEDURE: Bridging LVHR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immediate Effects of Different Rates of Thoracic Mobilization on Pressure Pain Thresholds in Asymptomatic Individuals
Status: COMPLETED
Conditions: Spine Stiffness
Interventions: OTHER: 2Hz mobilisation|OTHER: 0,5Hz mobilisation|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dasatinib in Treating Patients With Unresectable or Metastatic Squamous Cell Skin Cancer or RAI Stage 0-I Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Recurrent Skin Cancer|Squamous Cell Carcinoma of the Skin|Stage 0 Chronic Lymphocytic Leukemia|Stage I Chronic Lymphocytic Leukemia
Interventions: DRUG: dasatinib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Washington State Community Expedited Partner Treatment (EPT) Trial
Status: COMPLETED
Conditions: Gonorrhea|Neisseria Gonorrhoeae|Chlamydia Trachomatis
Interventions: OTHER: Patient delivered partner therapy|BEHAVIORAL: Targeted public health partner services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Low Calorie Diet and Diabetes
Status: ENROLLING_BY_INVITATION
Conditions: Diabetes Mellitus Type 2|Dyslipidemia|Non-alcoholic Fatty Liver Disease|Obesity
Interventions: BEHAVIORAL: Low calorie diet followed by life style intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Balance Exercise Program for Stroke Patients With Pusher Syndrome
Status: COMPLETED
Conditions: Pusher Syndrome|Subacute Stroke
Interventions: OTHER: Visual Feedback and Core Stability exercises protocol|OTHER: Control stroke
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Repeated Short-term Microgravity During Parabolic Flight Conditions on Neuro-endocrine, Immune and Metabolic Changes
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Parabolic flight|OTHER: neuro-endocrine measurements|OTHER: immunological measurements|OTHER: cellular energy metabolism measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Patupilone Versus Doxorubicin in Patients With Ovarian, Primary Fallopian, or Peritoneal Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Neoplasms
Interventions: DRUG: EPO906 (Patupilone)|DRUG: doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Interactions Between an Herbal Medicine (African Potato) and Antiretroviral Agents (Lopinavir/Ritonavir)
Status: COMPLETED
Conditions: Drug Interactions|Human Immunodeficiency Virus
Interventions: DRUG: Kaletra (lopinavir/ritonavir), African Potato (hypoxis obtusa)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Dexamethasone for Prevent Vomiting in Leukemic Children Who Receive Intrathecal Chemotherapy
Status: COMPLETED
Conditions: Acute Leukemic Patients in Children
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Double-blind Randomized Placebo-controlled Study Study of the Safety, Reactogenicity and Immunogenicity of the GamFluVac
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: GamFluVac|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Hydroxycinnamates and Beta-glucans as a Dietary Tool Against obesity_Pilot Study (OBHEALTH_PS)
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: Combination of oat beta-glucan of different richness (35 and 70%) at low (3g) and high (5g) doses with green coffee bean extract (600 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Prone Position With Different Types of Cushions in Patients With ARDS
Status: RECRUITING
Conditions: Prone Position|Acute Respiratory Distress Syndrome
Interventions: PROCEDURE: Prone position with thoraco-abdominal cushion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing the Effects of M-TAPA and TAP Block on Postoperative Analgesia in TAH
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: OTHER: M-TAPA block|OTHER: TAP block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Usefulness of Gadovist-enhanced FLAIR Imaging
Status: COMPLETED
Conditions: Malignant Tumors|Brain Lymphoma|CNS Lymphoma
Interventions: RADIATION: Usefulness of Gadovist-enhanced FLAIR imaging in differentiation between a glioblastoma and solitary brain metastasis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Oral Doses of GLPG0634 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG0634|DRUG: GLPG0634|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Action Observation Therapy Program in Patients With Neurogenic Dysphagia
Status: COMPLETED
Conditions: Neurogenic Dysphagia|Rehabilitation|Deglutition Disorders
Interventions: BEHAVIORAL: Action Observation Theraphy Group|BEHAVIORAL: Classic Swallowing Exercise Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combined PENG and LFCN Block for Total Hip Arthroplasty
Status: COMPLETED
Conditions: Anesthesia, Conduction|Pain, Postoperative|Arthroplasty, Replacement, Hip
Interventions: PROCEDURE: PENG + LFCN block|DRUG: Ropivacaine injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Information About the Operating Room Environment With Virtual Reality Glasses on the Anxiety Level
Status: COMPLETED
Conditions: Preoperative Anxiety
Interventions: OTHER: VR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Color Stability of NeoMTA Pulpotomized Primary Teeth
Status: UNKNOWN
Conditions: Dental Caries Extending to Pulp
Interventions: BIOLOGICAL: NeoMTA|BIOLOGICAL: Formocresol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Magnesium Sulfate in the Prevention of Post-ERCP Pancreatitis.
Status: TERMINATED
Conditions: Post-ERCP Pancreatitis
Interventions: DRUG: Magnesium Sulfate|DRUG: Placebo (NaCl 0,9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Interventional Testing of Gene-environment Interactions Via the Verifomics Mobile Application
Status: TERMINATED
Conditions: Obesity|Rhinitis|Rhinitis, Allergic|Respiratory Sounds|Dyspnea|Headache|Migraine Disorders|Arthritis|Arthralgia|Anxiety|Sleep Initiation and Maintenance Disorders|Sleep Deprivation
Interventions: DIETARY_SUPPLEMENT: Vitamin A|DIETARY_SUPPLEMENT: Vitamin B6|DIETARY_SUPPLEMENT: Vitamin C|DIETARY_SUPPLEMENT: Nicotinamide|DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Vitamin E|OTHER: Broccoli|OTHER: Spinach|DIETARY_SUPPLEMENT: Caffeine|OTHER: Coffee|DEVICE: Axon Eyewear|OTHER: Chocolate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Finding Alternatives to Standard Treatment for Attention-Deficit Hyperactivity Disorder
Status: NOT_YET_RECRUITING
Conditions: Attention-Deficit/Hyperactivity Disorder (ADHD)
Interventions: DEVICE: rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of an Infant Formula on Growth, Safety and Efficacy for Healthy Term Infants
Status: COMPLETED
Conditions: Infant Development
Interventions: OTHER: Study Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of Low-dose Albumin and Midodrine Versus Midodrine Alone in Outcome of Recurrent Ascites in Patients With Decompensated Cirrhosis.
Status: NOT_YET_RECRUITING
Conditions: Decompensated Cirrhosis
Interventions: DRUG: Albumin|DRUG: Midodrine|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Lung Ventilation Versus Two Lung Ventilation
Status: UNKNOWN
Conditions: Hypoxemia|Single Lung Ventilation
Interventions: PROCEDURE: Single lung ventilation by double lumen endotracheal tube|PROCEDURE: Two lung ventilation by conventional single lumen endotracheal tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study Of Poly (ADP-Ribose) Polymerase Inhibitor PF-01367338 In Combination With Several Chemotherapeutic Regimens
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: PF-01367338|DRUG: Carboplatin|DRUG: PF-01367338|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parent Specific Depression Education and Motivation
Status: COMPLETED
Conditions: Depressive Symptoms
Interventions: BEHAVIORAL: Parent-Specific Depression Education and Motivation|BEHAVIORAL: General Depression Education-Motivation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Immunogenicity of Motavizumab (MEDI-524) After Dosing for a Second Season in Children
Status: COMPLETED
Conditions: Motavizumab Administration for a Second Season for RSV Prophylaxis
Interventions: BIOLOGICAL: motavizumab (MEDI-524)|BIOLOGICAL: palivizumab 15 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Long Term Study of the Safety of Tanezumab When Administered By Subcutaneous Injections
Status: TERMINATED
Conditions: Osteoarthritis, Knee|Osteoarthritis, Hip
Interventions: DRUG: Tanezumab 2.5 mg|DRUG: Tanezumab 5 mg|DRUG: Tanezumab 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Combination Treatment of S-1 With Paclitaxel in Advanced Esophageal Cancer
Status: TERMINATED
Conditions: Esophageal Cancer
Interventions: DRUG: S-1 and Paclitaxel|DRUG: Paclitaxel and Cisplatin|DRUG: 5-FU and Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Afatinib in EGFR+NSCLC (Recurrent or Stage IV) - Patients With Poor Performance Status (ECOG 2 or 3)
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung|ErbB Receptors
Interventions: DRUG: Afatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous CD22 CAR T Cells in Adults w/ Recurrent or Refractory B Cell Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: B-ALL|B-cell Non Hodgkin Lymphoma|DLBCL|Follicular Lymphoma Grade 3B
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: CD22 CAR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TACE Combined With Lenvatinib and Sintilimab for Advanced HCC
Status: COMPLETED
Conditions: Hepatocellular Carcinoma Non-resectable
Interventions: DRUG: TACE combined with lenvatinib and sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of High-Intensity Interval Training Exercise in Adolescents With Hepatosteatosis
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease|Insulin Resistance|High Intensity Interval Training|Childhood Obesity
Interventions: OTHER: High-Intensity Interval Training (HIIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Lubiprostone and Placebo for the Relief of Constipation From Constipating Medications
Status: TERMINATED
Conditions: Constipation
Interventions: DRUG: lubiprostone|DRUG: Matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CAncer, NUtrition and Taste 2
Status: COMPLETED
Conditions: Breast Cancer|Gynecologic Cancer|Bronchial Cancer|Breast, Gynecological or Bronchial Cancer Treated With Intravenous Chemotherapy
Interventions: OTHER: CANUT support|OTHER: Anthropometric measures|OTHER: Prehension strength measurement|BEHAVIORAL: QVA Questionnaire|BEHAVIORAL: QLQ C30 Questionnaire|BEHAVIORAL: Scratch & Snif Test|BEHAVIORAL: Taste Strip Test|BEHAVIORAL: 24 H feed back questionnaire|BEHAVIORAL: Condiment questionnaire|BEHAVIORAL: Tobacco questionnaire|OTHER: Nutrition interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: To Compare the Efficacy and Safety of Perrigo's Product to an FDA Approved Product for the Treatment of Glaucoma or Ocular Hypertension in Both Eyes
Status: COMPLETED
Conditions: Glaucoma, Open-Angle|Ocular Hypertension
Interventions: DRUG: Brinzolamide/brimonidine ophthalmic suspension|DRUG: Simbrinza 0.2%/1% Ophthalmic Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Sleep Deprivation on Diaphragm Command During an Inspiratory Endurance Trial in Healthy Volunteers.
Status: COMPLETED
Conditions: Sleep Deprivation|Healthy Volunteers|Diaphragm
Interventions: BEHAVIORAL: Sleepless night|BEHAVIORAL: Normal sleep night
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Allogeneic T Cells Expressing T Cell Receptor-KDEL and the Chimeric Antigen Receptor CAT19 for the Treatment of Advanced CD19+ Malignancies
Status: NOT_YET_RECRUITING
Conditions: Blood Cancer
Interventions: GENETIC: KCAT19 T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of STALORAL® Birch 300 IR in a Paediatric Population With Birch Pollen-induced ARC w/o Asthma
Status: ACTIVE_NOT_RECRUITING
Conditions: Allergic Rhinoconjunctivitis|Birch Pollen Allergy
Interventions: DRUG: STALORAL® Birch 300 IR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Mass Balance of [14C] SY-5007 in Healthy Adult Male Subjects in China
Status: NOT_YET_RECRUITING
Conditions: Healthy Subjects
Interventions: DRUG: [14C] SY-5007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of Intradialytic Vasopressin on Chronic Hypertension in Patients With End Stage Renal Disease
Status: COMPLETED
Conditions: Hypertension|End Stage Renal Disease
Interventions: DRUG: Vasopressin - Very Low Dose|DRUG: Vasopressin - Low Dose|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of GlaxoSmithKline Biologicals Meningococcal Group B Vaccine When Administered Concomitantly With GlaxoSmithKline Biologicals MenACWY Conjugate Vaccine to Healthy Infants
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: Meningococcal group B Vaccine, rMenB+OMV NZ|BIOLOGICAL: Meningococcal ACWY Conjugate Vaccine, MenACWY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of Bimekizumab in Adult Subjects With Moderate to Severe Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Chronic Plaque Psoriasis|Moderate to Severe Chronic Plaque Psoriasis
Interventions: DRUG: Bimekizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plinabulin iv Solution in Prevention of TAC Induced Neutropenia
Status: COMPLETED
Conditions: Chemotherapy-induced Neutropenia
Interventions: DRUG: Plinabulin|DRUG: Pegfilgrastim|DRUG: Docetaxel, doxorubicin, and cyclophosphamide (TAC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Proactive Therapeutic Drug Monitoring Based Adalimumab Therapy Optimization in Patients With Rheumatoid Arthritis
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Therapeutic drug monitoring (TDM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Durvalumab as Consolidation Therapy in Non-Small Cell Lung Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Durvalumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FOLFIRI in Combination With Cetuximab in the First-line Treatment of Metastatic Colorectal Cancer Including a Regular Dermal Prophylaxis to Prevent Acneiforme Follicular Exanthema
Status: UNKNOWN
Conditions: Colorectal Cancer Metastatic
Interventions: DRUG: FOLFIRI + Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Curcumin, Quercetin and Vitamin D3 Supplements for Mild to Moderate Symptoms of COVID-19
Status: COMPLETED
Conditions: Covid-19
Interventions: DIETARY_SUPPLEMENT: Complementary therapy|DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Low Frequency STN DBS on Sleep and Vigilance in Parkinson's Disease (PD) Patients
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: OTHER: DBS stimulator setting alteration|OTHER: virtual reality simulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Antitumor Activity of Vactosertib in Combination With Pembrolizumab in Acral and Mucosal Melanoma Patients Progressed From Prior Immune Check Point Inhibitor
Status: NOT_YET_RECRUITING
Conditions: Acral Melanoma|Mucosal Melanoma
Interventions: DRUG: Pembrolizumab, Vactosertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Prophylactic Central Lymph Node Dissection in Papillary Thyroid Carcinoma
Status: COMPLETED
Conditions: Thyroid Cancer, Papillary
Interventions: PROCEDURE: prophylactic central lymph node dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Quality of Life Study of Dexlansoprazole Modified Release Formulation to Treat Heartburn
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: Dexlansoprazole MR|DRUG: Dexlansoprazole MR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Activity in Reducing Metabolic Dysregulation (MetD) in Obese Latina Breast Cancer Survivors
Status: WITHDRAWN
Conditions: Cancer Survivor|Central Obesity|No Evidence of Disease
Interventions: OTHER: Best Practice|BEHAVIORAL: Exercise Intervention|BEHAVIORAL: Exercise Intervention|OTHER: Laboratory Biomarker Analysis|DEVICE: Monitoring Device|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Volumetric Bone Mineral Density and it's Relationship With Osteoporotic Fractures in Parkinson's Disease
Status: COMPLETED
Conditions: Idiopathic Parkinson's Disease
Interventions: OTHER: High resolution peripheral scanner (HRpQCT).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Treatment of Hypopigmented Scars With Bimatoprost
Status: RECRUITING
Conditions: Scars|Hypopigmented Scar|Hypopigmented Skin|Burn Scar|Scarring|Cicatrix, Hypertrophic|Cicatrix|Pigmentation Disorder|Burns Laser
Interventions: DRUG: Bimatoprost|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PECS Study for CIED Implantation Surgery
Status: RECRUITING
Conditions: Pain, Postoperative|Child|Adolescent
Interventions: DRUG: Bupivacaine 0.25% with epinephrine 1:200000 by PECS block and wound infiltration|DRUG: Bupivacaine 0.25% with epinephrine 1:200000 by wound infiltration only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of EG-1962 in Aneurysmal Subarachnoid Hemorrhage
Status: COMPLETED
Conditions: Ruptured Cerebral Aneurysm|Ruptured Berry Aneurysm
Interventions: DRUG: Nimodipine|DRUG: Nimodipine Microparticles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Open-Label Exploratory Study of Saquinavir + Zidovudine + Lamivudine in HIV Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Saquinavir|DRUG: Lamivudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Probiotic Therapy in Preventing Gastrointestinal Complications in Patients Undergoing Chemotherapy and Pelvic Radiation Therapy
Status: WITHDRAWN
Conditions: Cognitive/Functional Effects|Constipation, Impaction, and Bowel Obstruction|Diarrhea|Fatigue|Gastrointestinal Complications|Psychosocial Effects of Cancer and Its Treatment|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DIETARY_SUPPLEMENT: live freeze-dried lactic acid bacteria probiotic|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the CloSys Closure System as an Adjunct to Standard Compression
Status: TERMINATED
Conditions: Sealing the Arteriotomy
Interventions: DEVICE: CloSys Hemostatic Device (HD)|PROCEDURE: Standard compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Influences of Dialysate Bicarbonate Concentrations on Hemodialysis Patients
Status: UNKNOWN
Conditions: End Stage Renal Disease on Dialysis
Interventions: PROCEDURE: Concentration of dialysate bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing CO2 Laser and Electrosurgical Treatments for Perianal Condyloma
Status: NOT_YET_RECRUITING
Conditions: Perianal Wart
Interventions: PROCEDURE: CO2 LASER Vaporisation|PROCEDURE: Electrosurgical Fulguration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability, and Pharmacokinetics of E2730 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: E2730|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing Optimal XRB Initiation Points in Jail
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder
Interventions: DRUG: Extended-Release Buprenorphine (XRB)|DRUG: Sublingual Buprenorphine (SLB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a New Airway Device - the YO2(R) Catheter in Patients Under Sedation
Status: UNKNOWN
Conditions: Patients Undergoing Anesthesiologist-administered iv Sedation During Diagnostic/ Therapeutic Procedures
Interventions: DEVICE: YO2(R) catheter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Immunogenicity Study of Fluval AB-Like Flu Vaccines With 3.5, 6, 9 or 15 μg HA in Adult and Elderly People
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Vaccination with FAB-3511|BIOLOGICAL: Vaccination with FAB-6011|BIOLOGICAL: Vaccination with FAB-9011|BIOLOGICAL: Vaccination with FluvalAB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing Reversal With Neostigmine and Sugammadex in Paediatric
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: DRUG: Neostigmine|DRUG: Sugammadex Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CHIP-AML22/Master: An Open Label Complex Clinical Trial in Newly Diagnosed Pediatric de Novo AML Patients
Status: RECRUITING
Conditions: Acute Myeloid Leukemia in Children
Interventions: DRUG: Standard Intervention Rc|DRUG: Investigational Intervention Rc|DRUG: Standard Intervention Ri|DRUG: Investigational Intervention Ri
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diclofenac Potassium With Lidocaine Cream in Reducing Pain During HSG
Status: COMPLETED
Conditions: Pain Relief With HSG
Interventions: DRUG: diclofenac potassium + lidocaine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Communication Skills to Build a Diverse Biomedical Workforce
Status: RECRUITING
Conditions: Behavioral Disorder
Interventions: OTHER: Communication Skills Training|OTHER: Communication Skills Training|OTHER: Educational Intervention|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Open-Label Study of SPN-812 Administered With Psychostimulants in Children and Adolescents With ADHD
Status: COMPLETED
Conditions: Attention-Deficit/Hyperactivity Disorder (ADHD)
Interventions: DRUG: SPN-812
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Association of Single Nucleotide Polymorphisms (SNPs) in Metalloproteinases (MMPs) Genes With the Risk of Primary Knee Osteoarthritis in Greek Population.
Status: UNKNOWN
Conditions: Metalloproteinase SNPs -1575 G/A MMP-2, 836 A/G MMP-9 and -77 A/G MMP-13 and Risk for Developing Knee Osteoarthritis in Greek Population
Interventions: OTHER: No intervention, Patients selection based on clinical symptoms and radiological imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Resin vs. Amorolfine vs. Terbinafine Treatment in Onychomycosis
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DEVICE: Resin Lacquer|DRUG: Amorolfine|DRUG: Terbinafine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mothers Living With HIV and Their Adolescent Children
Status: COMPLETED
Conditions: Family Relations|Mental Health|Physical Health|Risky Sexual Behavior|Substance Use|HIV Infections
Interventions: BEHAVIORAL: Cognitive-behavioral, small-group format sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Potential Impact of Disease Modifying Therapies on COVID-19 Outcomes and the Antibody Response Following an Infection With SARS-CoV-2 in Patients With Multiple Sclerosis Within the Swiss Multiple Sclerosis Cohort.
Status: UNKNOWN
Conditions: Multiple Sclerosis|COVID-19 (Severe Coronavirus Disease 2019)
Interventions: OTHER: data collection|OTHER: analysis of blood samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Feasibility of TMLI as Conditioning Regimen in Allogeneic Hematopoietic Stem-cell Transplantation
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia
Interventions: RADIATION: total marrow and total lymphoid irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Proprioceptive Neuromuscular Facilitation and Tendon Vibration After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Osteoarthritis|Total Knee Arthroplastry
Interventions: OTHER: PNF|OTHER: PNF plus Tendon Vibration|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Antiseptic Preoperative Scrubs in Prevention of Postoperative Infections
Status: COMPLETED
Conditions: Postoperative Wound Infection
Interventions: DRUG: chlorhexidine-alcohol|DRUG: Povidone-Iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating the Impact of Electronic Surveys on Patient-physician Communication and Quality of Life in Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Neoplasm Malignant Female
Interventions: OTHER: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Subcutaneous Belimumab or Placebo in Addition of Rituximab in Persistent or Chronic Immune Thrombocytopenia
Status: RECRUITING
Conditions: Primary Immune Thrombocytopenia (ITP)
Interventions: DRUG: Combination of Rituximab with subcutaneous belimumab|DRUG: Combination of Rituximab with subcutaneous placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cabozantinib and Androgen Ablation in Patients With Androgen-Dependent Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Cabozantinib|DRUG: Androgen Ablation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Dexmedetomidine on Microcirculation and Residual Kidney Function in Kidney Donors
Status: UNKNOWN
Conditions: Kidney Transplant|Microcirculation
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane (ESP) Block vs Intravenous Lignocaine Infusion in (VATS)
Status: NOT_YET_RECRUITING
Conditions: Thoracic Surgery, Video-Assisted
Interventions: PROCEDURE: Erector Spinae Plane (ESP) block|DRUG: Lignocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Role of Transcranial Direct Current Stimulation (tDCS) in Patients With Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DEVICE: tDCS active|DEVICE: tDCS sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Incontinence Analysis After HoLEP Using 28Fr Versus 22Fr Sheath
Status: ACTIVE_NOT_RECRUITING
Conditions: Urinary Incontinence
Interventions: PROCEDURE: HoLEP Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sofosbuvir Plus Ribavirin Administered for Either 12 or 24 Weeks in Treatment-Naive and Treatment-Experienced Egyptian Adults With Chronic Genotype 4 Hepatitis C Virus (HCV) Infection
Status: COMPLETED
Conditions: Hepatitis C Virus
Interventions: DRUG: SOF|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Efficacy and Safety of Choline Alfoscerate Compared to Placebo in Patients With Degenerative Mild Cognitive Impairment
Status: NOT_YET_RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: DRUG: Choline Alfoscerate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GLP-1R Agonist Treatment for Opioid Use Disorder
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder|Opioid Abuse and Addiction|Narcotic-Related Disorders|Substance-Related Disorders|Chemically-Induced Disorders|Mental Disorder|Opioid
Interventions: DRUG: Semaglutide Pen Injector|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outlook Quality of Life Intervention Study
Status: COMPLETED
Conditions: Cancer|Congestive Heart Failure (CHF)|Chronic Obstructive Pulmonary Disease (COPD)|End Stage Renal Disease (ESRD)
Interventions: OTHER: Life Completion|OTHER: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Omega 3 Polyunsaturated Fatty Acid Supplements (PUFAs) and Microvolt T Wave Alternans (TWA) in Patients With Ventricular Arrhythmia
Status: WITHDRAWN
Conditions: Arrhythmia|Defibrillators, Implantable
Interventions: DIETARY_SUPPLEMENT: n-3 polyunsaturated fatty acids (PUFAs)|DIETARY_SUPPLEMENT: olive oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Different Training Regimens on Electrical Stability Following Myocardial Infarction
Status: COMPLETED
Conditions: Ischemic Heart Disease|Congestive Heart Failure
Interventions: OTHER: aerobic training|OTHER: aerobic and strength training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Computerized Cognitive Training in Middle-Aged Adults With Generalized Anxiety Disorder: A Pilot Study
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: BEHAVIORAL: Cognitive Training|BEHAVIORAL: Trivia Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomechanical Analysis of the Effects of Upper Limb Orthosis During the Execution of a Functional Task
Status: UNKNOWN
Conditions: Orthotic Devices|Electromyography|Biomechanical Phenomena|Hand|Upper Extremity Dysfunction
Interventions: DEVICE: Hand Orthotic Devices
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The 'SILVERMAN1' Trial Single Incision Laparoscopic Versus Existing Resection (Minimal Access) for Neoplasia
Status: UNKNOWN
Conditions: Right Colon Tumors
Interventions: PROCEDURE: Patients will be divided in two groups- those having right colectomy by standard laparoscopy and those having Single Incision Laparoscopic Surgery (SILS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Iodine I-131 With or Without Selumetinib in Treating Patients With Recurrent or Metastatic Thyroid Cancer
Status: COMPLETED
Conditions: Metastatic Thyroid Gland Carcinoma|Poorly Differentiated Thyroid Gland Carcinoma|Recurrent Thyroid Gland Carcinoma|Stage IV Thyroid Gland Follicular Carcinoma AJCC v7|Stage IV Thyroid Gland Papillary Carcinoma AJCC v7|Stage IVA Thyroid Gland Follicular Carcinoma AJCC v7|Stage IVA Thyroid Gland Papillary Carcinoma AJCC v7|Stage IVB Thyroid Gland Follicular Carcinoma AJCC v7|Stage IVB Thyroid Gland Papillary Carcinoma AJCC v7|Stage IVC Thyroid Gland Follicular Carcinoma AJCC v7|Stage IVC Thyroid Gland Papillary Carcinoma AJCC v7
Interventions: RADIATION: Iodine I-131|OTHER: Placebo Administration|DRUG: Selumetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Ibrutinib + CD20 Antibody and Venetoclax in Patients With Untreated Mantle Cell Lymphoma
Status: RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Ibrutinib 560 mg|DRUG: Venetoclax 10 MG Oral Tablet [Venclexta]|DRUG: Venetoclax 50 MG Oral Tablet [Venclexta]|DRUG: Venetoclax 100 MG Oral Tablet [Venclexta]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of AKR-501 Tablets Taken Orally Once Daily for 28 Days in Patients With Chronic Idiopathic Thrombocytopenic Purpura (ITP)
Status: COMPLETED
Conditions: Chronic Idiopathic Thrombocytopenic Purpura|Purpura, Thrombocytopenic, Idiopathic
Interventions: DRUG: Placebo|DRUG: Avatrombopag tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT