pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of Chimeric Antigen Receptor T Cells Combined With Interventional Therapy in Advanced Liver Malignancy
Status: UNKNOWN
Conditions: Carcinoma, Hepatocellular|Pancreatic Cancer Metastatic|Colorectal Cancer Metastatic
Interventions: DRUG: CAR-T cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Dual Probe Ultrasonic Lithotripsy to a Single Probe Ultrasonic Lithotripsy
Status: COMPLETED
Conditions: Kidney Stones
Interventions: DEVICE: Cyberwand|DEVICE: single probe ultrasonic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Everolimus With Paclitaxel and Carboplatin in Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Metastatic Melanoma
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Broadly Neutralizing Antibodies 3BNC117-LS & 10-1074-LS to Prevent Relapse During ATI
Status: WITHDRAWN
Conditions: HIV Infections
Interventions: DRUG: 3BNC117-LS|DRUG: 10-1074-LS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing the Efficacy, Patient-reported Outcomes and Safety of Insulin Degludec 200 U/mL vs Insulin Glargine in Subjects With Type 2 Diabetes Mellitus Requiring High-dose Insulin
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec|DRUG: insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individual Versus Grouped Debriefing Approaches in Anaesthesia Crisis Simulation-Based Training. What Impact On The Technical Score ?
Status: COMPLETED
Conditions: Cardiac Arrest|Pregnancy
Interventions: OTHER: Grouped Debriefing|OTHER: Individual Debriefing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis
Status: WITHDRAWN
Conditions: Breast Carcinoma|Metastatic Malignant Neoplasm in the Brain|Metastatic Malignant Neoplasm in the Leptomeninges
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|RADIATION: Radiation Therapy|PROCEDURE: Resection|DRUG: Trotabresib|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab (MK3475), Gemcitabine, and Concurrent Hypofractionated Radiation Therapy for Muscle-Invasive Urothelial Cancer of the Bladder
Status: ACTIVE_NOT_RECRUITING
Conditions: Muscle-invasive Urothelial Cancer of the Bladder
Interventions: BIOLOGICAL: Pembrolizumab|PROCEDURE: Transurethral Resection of Bladder Tumor|DRUG: Gemcitabine|RADIATION: External Beam Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction Study to Evaluate the Effects of Ecopipam on the Pharmacokinetics of Multiple Substrates
Status: TERMINATED
Conditions: Drug-Interactions
Interventions: DRUG: ecopipam HCl ~2mg/kg/day|COMBINATION_PRODUCT: Cohort 1 Probe Cocktail|COMBINATION_PRODUCT: Cohort 2 Probe Cocktail|COMBINATION_PRODUCT: Cohort 3 Probe Cocktail
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-42165279 in Healthy Young and Elderly Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-42165279 50 mg|DRUG: JNJ-42165279 100 mg|DRUG: JNJ-42165279 30 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics (PK) in Multidrug-Resistant (MDR) Refractive Tuberculosis
Status: TERMINATED
Conditions: Tuberculosis
Interventions: DRUG: Delamanid|DRUG: Optimized Background Regimen (OBR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Timing of Initiation of LMWH Administration in Pregnant Women With APS
Status: COMPLETED
Conditions: Recurrent Miscarriage|Antiphospholipid Syndrome
Interventions: DRUG: Enoxaparin|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of SARS-Cov2 Pandemic on Severity of Perioperative Complications in Patients Undergoing Appendectomy
Status: UNKNOWN
Conditions: Postoperative Complications|Appendicitis|COVID-19 Pandemic|Appendicitis With Peritonitis
Interventions: PROCEDURE: appendectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: LDN and tDCS in Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: Low-Dose Naltrexone|DEVICE: Transcranial Direct Current Stimulation|DRUG: Placebo|DEVICE: Sham Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Terbutaline or a Reduction in Basal Insulin in the Prevention of Nocturnal Hypoglycemia
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Terbutaline|OTHER: 20% basal insulin reduction|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Surgical Procedure (Total Pancreatectomy) With a Transplant Procedure (Islet Cell Autotransplantation) for the Treatment of Chronic Pancreatitis and Benign Pancreatic Tumors
Status: NOT_YET_RECRUITING
Conditions: Benign Pancreatic Neoplasm|Chronic Pancreatitis|Recurrent Acute Pancreatitis
Interventions: PROCEDURE: Pancreatectomy|OTHER: Quality-of-Life Assessment|OTHER: Treatment Planning
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of The Use of Bolus in Post Mastectomy Irradiation in Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Radiodermatitis
Interventions: RADIATION: No Bolus|RADIATION: Alternate Bolus|RADIATION: Continuous Bolus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intubation During Resuscitation
Status: COMPLETED
Conditions: Intubation|Cardiopulmonary Resuscitation
Interventions: DEVICE: The Bonfils Intubation Fibrescope|DEVICE: The Video Rigid Flexing Laryngoscope|DEVICE: The C-MAC® S Video Laryngoscope|DEVICE: The Macintosh Laryngoscope
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Three Small Doses of HCG Versus Booster Dose of HCG on Ovum Pickup Day
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: IVF/ICSI|DRUG: Human Chorionic Gonadotropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurofeedback Rehabilitation Based on Motor Imaging in Patients in the Immobilization Phase
Status: UNKNOWN
Conditions: Healthy Subjects, Patients With Amyotrophic Lateral Sclerosis, Patients With Shoulder Surgery
Interventions: DEVICE: Videogames
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Motivational Interviewing to Increase Parent Engagement in Preventive Parenting Programming
Status: COMPLETED
Conditions: Behavior Problems|Parent-Child Relations
Interventions: BEHAVIORAL: Motivational Interviewing|BEHAVIORAL: Anticipatory Guidance on Child Development
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The EPIVER Randomized Controlled Trial
Status: COMPLETED
Conditions: ST Elevation Myocardial Infarction|Percutaneous Coronary Intervention|No-Reflow Phenomenon
Interventions: DRUG: Standard therapy|DRUG: Epinephrine|DRUG: Verapamil|DRUG: Epinephrine + verapamil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increasing Help-Seeking Behavior Among Transitioning Veterans at Risk for Suicide With Online Gatekeeper Training
Status: COMPLETED
Conditions: Suicide Prevention
Interventions: BEHAVIORAL: VA S.A.V.E.|BEHAVIORAL: Sham intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intra-operative Chemotherapy With 5-FU for Colorectal Cancer Patients Receiving Curative Resection: Efficacy and Safety
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: PROCEDURE: curative resection for colorectal cancer|DRUG: intra-operative 5-FU chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diet and Lifestyle Intervention Study in Postpartum Women in China
Status: UNKNOWN
Conditions: Puerperal Infection|Fever|Constipation|Hemorrhoids|Anal Fissure|Breast Disease|Oral Ulcers|Anemia
Interventions: BEHAVIORAL: Diet and Lifestyle Intervention in Chinese Postpartum Women
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nd:YAG Laser Hyaloidotomy for Premacular Hemorrhage in Diabetic Eyes
Status: COMPLETED
Conditions: Proliferative Diabetic Retinopathy
Interventions: PROCEDURE: Nd:YAG laser Hyaloidotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Whether Digital Acceptance Commitment Therapy Can Improve Mental Health for Hong Kong Cancer Patients Suffering From Depressive and Anxiety Symptoms.
Status: NOT_YET_RECRUITING
Conditions: Depression, Anxiety|Quality of Life|Cancer
Interventions: DEVICE: Acceptance and Commitment Therapy|OTHER: Psychoeducation Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Interpretation Training to Reduce Anxiety: Evaluating Technology-based Delivery Models and Methods to Reduce Attrition
Status: RECRUITING
Conditions: Anxiety
Interventions: BEHAVIORAL: Cognitive Bias Modification - Interpretation training|BEHAVIORAL: Coaching|BEHAVIORAL: Online psychoeducation about anxiety
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of System Interventions to Increase HPV Vaccine Receipt in FQHCs
Status: ENROLLING_BY_INVITATION
Conditions: Human Papillomavirus Infection
Interventions: BEHAVIORAL: Parent Reminders|BEHAVIORAL: Multicomponent clinic-system strategies|BEHAVIORAL: Combined Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Atherectomy and Drug Coated Balloon for the Treatment of Arterio-Venous Graft Stenosis
Status: UNKNOWN
Conditions: Dysfunctional Arterial-venous Grafts
Interventions: DEVICE: Atherectomy and balloon angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Evaluation and Standardization of Ginseng and Its Components for Blood Pressure Regulation
Status: COMPLETED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Korean Red Ginseng|DIETARY_SUPPLEMENT: Corn Starch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diet, Exercise and/or Rosiglitazone for HIV-Associated Insulin Resistance
Status: COMPLETED
Conditions: HIV Infections|Insulin Resistance|Obesity
Interventions: BEHAVIORAL: Weight loss through diet and exercise|DRUG: Rosiglitazone insulin sensitizing agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of RF and crYoballoon ablatiOn Therapy of AF（CRYO-AF）
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: cryoballoon ablation|PROCEDURE: radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial With Intranasal Fentanyl in Cancer Patients With Breakthrough Pain
Status: COMPLETED
Conditions: Break Through Pain|Cancer
Interventions: DRUG: Intranasal Fentanyl Spray (INFS)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study With Seletracetam (Ucb 44212) in Adult Subjects (18 to 65 Years) With Partial Onset Seizures
Status: COMPLETED
Conditions: Epilepsy, Partial
Interventions: DRUG: Seletracetam (ucb 44212)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Continuous Versus Intermittent Linezolid Infusion in Critically Ill Patients With Septic Shock
Status: RECRUITING
Conditions: Treatment Efficacy
Interventions: DRUG: Linezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Treatment With Corifollitropin Alpha in Vitro Fertilization in Patients With Poor Ovarian Response.
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Ganirelix 0.25 mg.|DRUG: Recombinant choriogonadotropin alfa|DRUG: Micronized natural progesterone.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of SHR-1702 Monotherapy in Patients With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)
Status: COMPLETED
Conditions: AML|MDS
Interventions: DRUG: SHR-1702
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Pharmacokinetic and Pharmacodynamic Biosimilarity of CHS-1701 (Coherus Pegfilgrastim) With Neulasta® (Pegfilgrastim)
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: CHS-1701|DRUG: Pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Gene Transfer Study to Evaluate the Safety, Tolerability and Efficacy of SRP-6004 in Ambulatory Participants With Limb Girdle Muscular Dystrophy, Type 2B/R2 (LGMD2B/R2, Dysferlin [DYSF] Related)
Status: ACTIVE_NOT_RECRUITING
Conditions: Limb Girdle Muscular Dystrophy
Interventions: GENETIC: SRP-6004
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Confirmatory Study of Topical HyBryte™ vs. Placebo for the Treatment of CTCL
Status: NOT_YET_RECRUITING
Conditions: CTCL/ Mycosis Fungoides|CTCL|Mycosis Fungoides|Cutaneous T Cell Lymphoma
Interventions: DRUG: Hypericin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Helical Tomotherapy as a Radiotherapy Technique for Treating Pelvic and Abdominal Metastases
Status: COMPLETED
Conditions: Neoplasm Metastasis|Carcinoma
Interventions: PROCEDURE: Tomotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Temsirolimus (CCI-779) In Breast Neoplasms
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Letrozole / Temsirolimus (CCI-779)|DRUG: Letrozole / Temsirolimus (CCI-779)|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Periodontal Regeneration of Chronic Periodontal Disease Patients Receiving Stem Cells Injection Therapy
Status: UNKNOWN
Conditions: Periodontal Diseases
Interventions: GENETIC: DPSC injection|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Clinical Trial of the Safety and Efficacy of Telmisartan for the Mitigation of Pulmonary and Cardiac Complications in COVID-19 Patients
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Telmisartan 40mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sensory-Motor Integration for Speech Rehabilitation in Patients With Post-stroke Aphasia
Status: RECRUITING
Conditions: Aphasia Non Fluent|Stroke
Interventions: DEVICE: Enriched rehabilitation|DEVICE: Simple rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study to Evaluate Deep Brain Stimulation (DBS) Settings for the Treatment of Parkinson's Disease
Status: WITHDRAWN
Conditions: Parkinson's Disease
Interventions: DEVICE: GUIDE software, Version 0.1|DEVICE: Clinically defined stimulation parameters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PRT3789 Monotherapy and in Combo w/Docetaxel in Participants w/Advanced or Metastatic Solid Tumors w/SMARCA4 Mutation
Status: RECRUITING
Conditions: Advanced Solid Tumor|Metastatic Solid Tumor|Non-small Cell Lung Cancers|SMARCA4 Gene Mutation
Interventions: DRUG: PRT3789|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impulsivity With Borderline Personality Disorder/tMS
Status: RECRUITING
Conditions: Borderline Personality Disorder
Interventions: DEVICE: Non-invasive brain stimulation protocol (Cortico-cortical paired associative stimulation protocol (ccPAS)) delivered at 4 ms intervals.|DEVICE: Non-invasive brain stimulation protocol (Cortico-cortical paired associative stimulation protocol (ccPAS)) delivered at 100 ms intervals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Study of Rebamipide in Patients With Active Ulcerative Colitis
Status: COMPLETED
Conditions: Colitis, Ulcerative
Interventions: DRUG: rebamipide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 68Ga PSMA PET for Patients With Biochemical Recurrence of Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Prostatic Neoplasm|Prostatic Neoplasms, Castration-Resistant|Prostatic Cancer Recurrent|Prostatic Cancer Metastatic
Interventions: DRUG: Ga-68 PSMA-HBED-CC PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Regular Exercise Improves Physical Capacity and Promotes Neurotrophins in Patients With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Exercise Intervention|Neuro-Degenerative Disease
Interventions: BEHAVIORAL: Regular Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Allogeneic NK T-Cells Expressing CD19 Specific CAR in B-Cell Malignancies
Status: RECRUITING
Conditions: NHL, Relapsed, Adult|B-cell Lymphoma|B-cell Leukemia|DLBCL - Diffuse Large B Cell Lymphoma|ALL, Adult B Cell|ALL, Childhood|CLL/SLL
Interventions: GENETIC: KUR-502
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy of Two Treatment Schemes With Antivipmyn ® for the Treatment of Snake Bite Envenomation
Status: TERMINATED
Conditions: Snake Bite
Interventions: BIOLOGICAL: A|BIOLOGICAL: Antivipmyn ®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KORTUC: Intra-tumoural Hydrogen Peroxide as a Radiation Sensitizer in Patients With Locally Advanced/Recurrent Breast Cancer in Terms of Toxicity and Tumour Response
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Hydrogen Peroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Neurocognitive Effects of Low-dose Radiation in the Brain: Study of 150 Patients in the French Hemangioma Cohort
Status: UNKNOWN
Conditions: Patients Treated by Radiotherapy With < One Gy to the Brain
Interventions: OTHER: neurocognitive tests battery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Pleural Abrasion Plus Minocycline Versus Apical Pleurectomy for Primary Spontaneous Pneumothorax
Status: UNKNOWN
Conditions: Pneumothorax
Interventions: PROCEDURE: 1 apical pleurectomy|PROCEDURE: 2 pleural abrasion + minocycline pleurodesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remediation of Spatial Neglect Trial
Status: COMPLETED
Conditions: Stroke|Acquired Brain Injury|Hemispatial Neglect
Interventions: OTHER: Computerized Plasticity-based Adaptive Cognitive Training|OTHER: Commercially available computerized training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Clinical Trial of NPB-01maintenance Therapy in Patients With Chronic Inflammatory Demyelinating Polyneuropathy.
Status: COMPLETED
Conditions: Chronic Inflammatory Demyelinating Polyneuropathy
Interventions: DRUG: NPB-01
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closed-loop Spinal Stimulation for Restoration of Upper Extremity Function After Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Open-loop Stimulation|DEVICE: Close-loop Stimulation|OTHER: Functional Task Practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of the PEAK PlasmaBlade 4.0 in Bilateral Breast Reduction
Status: WITHDRAWN
Conditions: Macromastia (Symptomatic)
Interventions: DEVICE: PEAK PlasmaBlade|PROCEDURE: Scalpel and Traditional Electrosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosis
Status: UNKNOWN
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DEVICE: surgical implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Steristrips Adhesive Tape Versus Subcuticular Suture for Episiotomy Repair in Primigravid Obese Women
Status: COMPLETED
Conditions: Episiotomy Wound
Interventions: PROCEDURE: Adhesive tape|PROCEDURE: Continuous subcuticular skin suturing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of the Management of COVID-19 Through Tailored Recommendations to the Citizens
Status: UNKNOWN
Conditions: COVID19|Tailored Recommendations|Citizen Self-reported Symptoms
Interventions: BEHAVIORAL: Tailored recommendations|BEHAVIORAL: General recommendation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Double-blinded, Randomised, Four-period Crossover Euglycemic Clamp Trial Investigating the Dose-response and Dose-exposure Relationship of BioChaperone Insulin Lispro in Three Different Doses in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus Type 1
Interventions: DRUG: BioChaperone insulin lispro 0.2U/Kg|DRUG: BioChaperone insulin lispro 0.1U/Kg|DRUG: BioChaperone insulin lispro 0.4U/Kg|DRUG: Humalog®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Aliskiren 300 mg, 150 mg and 75 mg in Patients With Essential Hypertension Compared to Ramipril 5 mg
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Aliskiren|DRUG: Ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomised Trial of Artesunate-sulfamethoxypyrazine/Pyrimethamine Versus Praziquantel for the Treatment of S. Mansoni
Status: COMPLETED
Conditions: Schistosoma Mansoni
Interventions: DRUG: Artesunate+Sulfamethoxypyrazine/pyrimethamine|DRUG: Praziquantel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Utility of MR Lymphangiography in Postoperative Follow-up of Lymphedema: Comparison With Lymphoscintigraphy
Status: UNKNOWN
Conditions: Lymphedema
Interventions: PROCEDURE: lymphangiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Levonorgestrel-intrauterine System (LNG-IUS) Versus Depot Medroxyprogesterone Acetate (DMPA) in Treatment of Pelvic Pain in Clinically Diagnosed Endometriotic Patients
Status: COMPLETED
Conditions: Clinically Diagnosed Endometriotic Patient Was Defined as a Woman Who Has Pelvic Pain and at Least One Evidence of PV or TVS
Interventions: DRUG: Depot medroxyprogesterone acetate|DEVICE: LNG-IUS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Positive Airway Pressure (PAP) Titration and Treatment Versus Auto-adjusting PAP Treatment for Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Continuous positive airway pressure|DEVICE: Auto-adjusting positive airway pressure treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Exercise, Weight Loss, and Exercise Plus Weight Loss on Sleep Apnea
Status: TERMINATED
Conditions: Obstructive Sleep Apnea|Overweight
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: Weight Loss|BEHAVIORAL: Exercise + Weight Loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementing Fit Kit Colorectal Cancer (CRC) Screening in High Risk Populations
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BEHAVIORAL: CRC screening reminder|BEHAVIORAL: CRC Reminder & Short message|BEHAVIORAL: CRC Reminder and Navigation Program|BEHAVIORAL: CRC Reminder & CRC education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: The Current Study Aimed to Evaluate the Therapeutic Features and Complications of Liver Hydatid Cyst in Patients Who Underwent Surgery for CE in Fars Province, Southern Iran.
Status: COMPLETED
Conditions: Patients Who Underwent Surgury for Hydatid Cyst
Interventions: OTHER: No intervention.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Thalidomide/Dexamethasone vs MP for Induction Therapy and Thalidomide/Intron A vs Intron A for Maintenance Therapy
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Thalidomide/Dexamethasone vs Melphalan/Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Safety and Efficacy of CAR-T Cells Targeting CD123 in Patients With Acute Leukemia
Status: TERMINATED
Conditions: Acute Leukemia|Acute Leukemia in Relapse|Acute Myeloid Leukemia|Relapsed or Refractory Acute Leukemia
Interventions: DRUG: anti-CD123 CAR-T treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Potential Use of Inhaled Hydroxychloroquine for the Treatment of COVID-19 in Cancer Patients
Status: WITHDRAWN
Conditions: 2019 Novel Coronavirus
Interventions: DRUG: HCQ01|DRUG: standard of care (SOC) for COVID-19
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of (R)-Roscovitine Safety and Effects in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DRUG: Roscovitine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sativex® for Relieving Persistent Pain in Participants With Advanced Cancer
Status: COMPLETED
Conditions: Pain|Advanced Cancer
Interventions: DRUG: Nabiximols|DRUG: Placebo (GA-0034)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Paracetamol on Kidney Function in Severe Malaria
Status: RECRUITING
Conditions: Severe Malaria|Malaria,Falciparum|Acute Kidney Injury|Paracetamol
Interventions: DRUG: Paracetamol|PROCEDURE: Mechanical antipyresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Clinical Investigation of the C2a-Taper™ Acetabular System
Status: COMPLETED
Conditions: Osteoarthritis|Avascular Necrosis|Congenital Hip Dysplasia|Traumatic Arthritis
Interventions: DEVICE: C2a - Taper™ Acetabular System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Assess Safety and Effect of Olaparib on the Pharmacokinetics of Anastrozole, Letrozole & Tamoxifen, and Their Effect on Olaparib, in Patients With Advanced Solid Cancer
Status: COMPLETED
Conditions: Solid Tumours
Interventions: DRUG: Olaparib|DRUG: Tamoxifen|DRUG: Anastrozole|DRUG: Letrozole|PROCEDURE: Pharmacokinetic sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety Study of AP23573 in Patients With Progressive or Recurrent Glioma (8669-023)(COMPLETED)
Status: COMPLETED
Conditions: Malignant Glioma|Glioblastoma|Gliosarcoma
Interventions: DRUG: AP23573
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carotid Artery Corrected Flow Time as a Predictor of Hypotension After Induction of General Anesthesia in Elderly Patients
Status: COMPLETED
Conditions: General Anesthesia Induction for Elective Surgery
Interventions: PROCEDURE: ultrasonographic measurement of carotid artery corrected flow time (FTc)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Stress Urinary Incontinence Physiotherapy
Status: UNKNOWN
Conditions: Urinary Incontinence, Stress
Interventions: OTHER: Involuntary muscle contractions|OTHER: Voluntary muscle contractions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Study to Evaluate Biomarkers and Safety in Systemic Sclerosis Patients Treated With ABR-215757 (Paquinimod)
Status: COMPLETED
Conditions: Systemic Sclerosis
Interventions: DRUG: paquinimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study With KIN-1901 in Healthy Subjects and Subjects With Ankylosing Spondylitis
Status: COMPLETED
Conditions: Inflammation|Rheumatic Diseases
Interventions: DRUG: KIN-1901|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Establishment of Operation Space Between High Position and Low Position in Endoscopic Thyroid Surgery
Status: UNKNOWN
Conditions: Thyroid Cancer|Endoscopy
Interventions: PROCEDURE: high position space group|PROCEDURE: low position space group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fibrin Sealant in Decreasing Lymphedema Following Surgery to Remove Lymph Nodes in Patients With Cancer of the Vulva
Status: COMPLETED
Conditions: Lymphedema|Perioperative/Postoperative Complications|Vulvar Cancer
Interventions: DRUG: fibrin sealant|PROCEDURE: surgical wound closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oral Vancomycin Versus Probiotics Versus Placebo for Prevention of Clostridium Difficile Infection in Colonized Patients
Status: RECRUITING
Conditions: Clostridium Difficile Colonization|Clostridium Difficile Diarrhea
Interventions: DRUG: Vancomycin|DIETARY_SUPPLEMENT: Culturelle|DRUG: Vancomycin Placebo|DRUG: Probiotic Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Ganetespib in Combination With Paclitaxel, Carboplatin, and Radiation Therapy in Treating Patients With Stage II-III Esophageal Cancer
Status: COMPLETED
Conditions: Gastroesophageal Junction Adenocarcinoma|Malignant Neoplasm of the Cervical Esophagus|Malignant Neoplasm of the Thoracic Esophagus|Stage IIA Esophageal Cancer AJCC v7|Stage IIB Esophageal Cancer AJCC v7|Stage IIIA Esophageal Cancer AJCC v7|Stage IIIB Esophageal Cancer AJCC v7|Stage IIIC Esophageal Cancer AJCC v7
Interventions: DRUG: Carboplatin|DRUG: Ganetespib|DRUG: Paclitaxel|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Rituximab With Standard Intrathecal Prophylaxis to Prevent CNS Relapse for CD 20+ Non Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Hodgkin Lymphoma
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Urinary Retention After Laparoscopic Inguinal Hernia Repair: Comparing the Use of the Intraoperative Urinary Catheter
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: DEVICE: Urinary Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: How Future Surgery Will Benefit From Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Related Measures Perspective From Italian Young Surgeon Society (SPIGC)
Status: COMPLETED
Conditions: COVID-19|Health Behavior
Interventions: BEHAVIORAL: COVID-surg-SPIGC questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating HA 0.15% Compared With Cyclosporine 0.05%, and Efficacy of Combination Therapy in Dry Eye Disease Patients
Status: COMPLETED
Conditions: Dry Eye|Dry Eye Syndromes
Interventions: DRUG: TJO-018 (HA 0.15%)|DRUG: Cyclosporine Ophthalmic Emulsion 0.05% standard therapy (CMC 0.5% add)|DRUG: TJO-018 (HA 0.15%) + Cyclosporine Ophthalmic Emulsion 0.05%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neurofunctional Predictors of Escitalopram Treatment Response in Adolescents With Anxiety
Status: COMPLETED
Conditions: Anxiety
Interventions: DRUG: Escitalopram|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sorilux in Maintenance Treatment of Moderate Type Plaque Psoriasis
Status: UNKNOWN
Conditions: Plaque Psoriasis
Interventions: DRUG: LEXETTE 0.05% Topical Foam|DRUG: Sorilux 0.005 % Topical Foam|OTHER: Vehicle Foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Serplulimab Combined With Chemotherapy in Patients With Resectable Esophageal Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma|Neoadjuvant Therapy
Interventions: COMBINATION_PRODUCT: Serplulimab, Albumin paclitaxel, carboplatin AUC=5, neoadjuvant therapy|PROCEDURE: Esophagectomy|OTHER: sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Define the Optimal Uptake Time of 68Ga-OPS202 When Used as a PET (Positron Emission Tomography) Imaging Agent in Subjects With Newly Diagnosed Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Satoreotide trizoxetan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 3 Study to Compare the Efficacy and Safety of Co-administered HGP0608, HGP0904 and HCP1306 Versus HCP1701 in Patients With Hypertension and Dyslipidemia
Status: COMPLETED
Conditions: Hypertension|Dyslipidemias
Interventions: DRUG: HCP1701|DRUG: Losartan|DRUG: Amlodipine|DRUG: Rosuvastatin and Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Minnelide Along With Abraxane Plus Gemcitabine in Patients With Metastatic Adenocarcinoma of the Pancreas
Status: RECRUITING
Conditions: Metastatic Adenocarcinoma of the Pancreas
Interventions: COMBINATION_PRODUCT: Minnelide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Intranasal Repeat Dose Effect of Levocabastine in the Subjects With Allergic Rhinitis
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial and Seasonal
Interventions: DRUG: Levocabastine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Controlled Loading on Conservative Treated Achilles Tendon Ruptures
Status: COMPLETED
Conditions: Tendon Injuries|Soft Tissue Injuries|Achilles Tendon Rupture
Interventions: DEVICE: Early loading on a training pedal|OTHER: Tendon strain exercises|OTHER: Early weight bearing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quadratus Lumborum Block for Percutaneous Nephrostomy
Status: WITHDRAWN
Conditions: Nephrostomy; Complications|Upper Urinary Tract Dilatation and Obstruction|Regional Anesthesia Morbidity|Adverse Anesthesia Outcome
Interventions: PROCEDURE: Local Anesthetic infiltration|PROCEDURE: Quadratus Lumborum block|DRUG: MAC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: TRPA1-inhibitor|DRUG: TRPV1-inhibitor|DRUG: TRPM3-inhibitor|DRUG: Placebo|DRUG: Chloride-channel inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Endometriosis and Complement System
Status: COMPLETED
Conditions: Endometriosis|Complement System|Alternative Complement Pathway
Interventions: DIAGNOSTIC_TEST: Mannose-binding lectin-associated serine protease-3 (MASP-3) Level|DIAGNOSTIC_TEST: Adipsin Level|DIAGNOSTIC_TEST: Properdin Level|DIAGNOSTIC_TEST: Complement Factor H (CFH) Level|DIAGNOSTIC_TEST: Cancer Antigen 125 (CA-125) Level
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Bacillus Subtilis R0179 in Healthy Young Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: B. subtilis R0179|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: CPX-351 and Glasdegib for Newly Diagnosed Acute Myelogenous Leukemia With MDS Related Changes or Therapy-related Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myelogenous Leukemia (AML) Due to Therapy|Acute Myeloid Leukemia With Myelodysplasia-Related Changes
Interventions: DRUG: Glasdegib|DRUG: CPX-351
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studying Fentanyl in Patients With Cancer
Status: TERMINATED
Conditions: Brain and Central Nervous System Tumors|Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Lymphoproliferative Disorder|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Pain|Precancerous Condition|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: fentanyl citrate|OTHER: pharmacological study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Dexlansoprazole MR to Placebo on the Ability to Maintain Healing in Subjects With Healed Erosive Esophagitis
Status: COMPLETED
Conditions: Esophagitis, Reflux|Esophagitis, Peptic
Interventions: DRUG: Dexlansoprazole MR|DRUG: Dexlansoprazole MR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Complex Renal Cyst With CEUS/Functional MRI Versus CT
Status: COMPLETED
Conditions: Cystic Renal Diseases|Kidney Neoplasms
Interventions: OTHER: Blood/urine sampling|OTHER: Conventional routine CT examination|OTHER: Contrast-enhanced renal ultrasonography (CEUS)|OTHER: Functional MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: S.P.PRO LIVER POWDER is Used to Improve Liver and Metabolic Indexes in People With Non-alcoholic Fatty Liver Disease
Status: UNKNOWN
Conditions: Liver Diseases
Interventions: DRUG: Shen Pu Yang Gan Wan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PED NEONAT 20-000599 Fetal Body Composition
Status: COMPLETED
Conditions: IUGR|Gestational Diabetes|Pregnancy Related
Interventions: OTHER: 3T "Free-Breathing" Fetal Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Effects of AMG 811 in Subjects With Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: AMG 811 or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Don't Throw Your Heart Away: Patient Study 4
Status: COMPLETED
Conditions: Cardiac Transplant Disorder
Interventions: OTHER: Stratified Transplant Survival Metric|OTHER: SRTR Information Format
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Phenotype and Genotype Correlations in Patients With Contiguous Gene Deletion Syndromes
Status: COMPLETED
Conditions: Williams Syndrome|Angelman Syndrome|Prader-Willi Syndrome|Shprintzen Syndrome|Smith-Magenis Syndrome|DiGeorge Syndrome|Chromosome Abnormalities
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Safety and Effectiveness of CVA-FLOW Software Device for Acute Ischemic Stroke
Status: RECRUITING
Conditions: Stroke|Stroke, Acute|Stroke, Ischemic|Stroke, Cardiovascular|Stroke Hemorrhagic
Interventions: DIAGNOSTIC_TEST: CVAid Flow
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC