pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Novel Approach for Alleviating the Side Effects of Chemotherapeutic Agents.
Status: COMPLETED
Conditions: Breast Cancer|Lung Cancer|Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: Chemotherapeutic agent A(Docetaxel),B(Cisplatin) or C(Docetaxel) plus Dietary Supplement (RaproCell)|DRUG: Chemotherapeutic agent A(Docetaxel),B(Cisplatin) or C(Docetaxel) plus placebo|DRUG: Chemotherapeutic agent A(Docetaxel),B(Cisplatin) or C(Docetaxel).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity Diagnostics
Status: RECRUITING
Conditions: Malaria,Falciparum|Malaria in Pregnancy|Malaria in Childbirth|Pregnancy|Neonatal Health|Low Birthweight|Stillbirth|Gestational Age and Weight Conditions|Preterm Birth
Interventions: DIAGNOSTIC_TEST: Malaria High-Sensitivity Rapid Diagnostic Test (HS-RDT)|DRUG: Artemether-Lumefantrine 20 Mg-120 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Clinical Results of Small Incision Lenticule Extraction (SMILE) for the Correction of High Myopia
Status: RECRUITING
Conditions: Myopia|High Myopia
Interventions: OTHER: Small Incision Lenticule Extraction (SMILE) with Visumax (Carl Zeiss Meditec, Jena)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dyanavel® XR Extended-Release Oral Suspension in the Treatment of Children With ADHD: A Laboratory School Study
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: amphetamine extended-release oral suspension, 2.5 mg/mL|DRUG: Placebo extended-release oral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial of NSAID Dosing Strategies
Status: COMPLETED
Conditions: Musculoskeletal Pain|Acute Pain
Interventions: DRUG: NSAID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Assess the Safety and Efficacy of IMO-2125 With 8 mg Ipilimumab in Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Metastatic Melanoma
Interventions: DRUG: IMO-2125|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of BMS-936558 (Nivolumab) Compared to Docetaxel in Previously Treated Metastatic Non-squamous NSCLC
Status: COMPLETED
Conditions: Non-Squamous Cell Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: Nivolumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Desmoteplase in Japanese Patients With Acute Ischemic Stroke
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Desmoteplase|DRUG: Desmoteplase|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Treatment Effectiveness of Guideline Indicated APT for ACS in Patients With CKD
Status: UNKNOWN
Conditions: Chronic Kidney Diseases|Acute Coronary Syndrome
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Genetically Informed Smoking Cessation Trial
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Combination NRT (Nicotine patch, Nicotine lozenge)|DRUG: Varenicline|DRUG: Placebo|BEHAVIORAL: Intensive smoking counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Educational Intervention to Teach Principles of Evidence-based Medicine (EbM) in Biology Classes
Status: UNKNOWN
Conditions: Health Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: Experimental educational intervention|BEHAVIORAL: Standard educational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Safety and Tolerability of GT0918 in Subjects With mHSPC and mCRPC
Status: COMPLETED
Conditions: Metastatic Castrate Resistant Prostate Cancer (mCRPC)|Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
Interventions: DRUG: GT0918
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effect of Physical Therapy With Oral Appliance on Temporomandibular Disorder Related Myofascial Pain
Status: COMPLETED
Conditions: Temporomandibular Disorder
Interventions: OTHER: PT program|DEVICE: oral appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improved Access to Quality Care and Healthcare Use
Status: RECRUITING
Conditions: Health Care Utilization|Health Knowledge, Attitudes, Practice|Health, Subjective
Interventions: OTHER: Free high-quality care|OTHER: Close distance|OTHER: Far distance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Investigate the Safety and Tolerability of AZD8848 in Butyrylcholinesterase Deficient Subjects
Status: COMPLETED
Conditions: Butyrylcholinesterase Deficiency
Interventions: DRUG: AZD8848
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Human interferon alfa 1b inhalation solution|DRUG: Human interferon alfa 1b inhalation solution placebo|DRUG: Human interferon alfa 1b inhalation solution|DRUG: Human interferon alfa 1b inhalation solution placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nutraceutical Effects on Long-Term Memory
Status: COMPLETED
Conditions: Aging
Interventions: DRUG: NT-020|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influence of Esmolol on a Closed-Loop Anesthesia System
Status: TERMINATED
Conditions: Anesthesia
Interventions: DRUG: NaCl 9/00|DRUG: Esmolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of MDX-1100 (Anti-CXCL10 Human Monoclonal Antibody) in Combination With Methotrexate in Subjects With Active Rheumatoid Arthritis (RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: MDX-1100|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fuel Utilization, Diet Composition, and Exercise in African American Women
Status: COMPLETED
Conditions: Obesity|Diabetes|Insulin Resistance
Interventions: OTHER: High Intensity Interval Training (HIIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a Candidate Tuberculosis (TB) Vaccine in HIV-positive Adults.
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: GSK's candidate Mycobacterium tuberculosis vaccine 692342|BIOLOGICAL: Control vaccine with the adjuvant system.|BIOLOGICAL: Control vaccine with physiological saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Salpingectomy at the Time of Elective Laparoscopic Cholecystectomy (SaLCHE)
Status: COMPLETED
Conditions: Prophylactic Salpingectomy|Opportunistic Salpingectomy|Laparoscopic Cholecystectomy
Interventions: PROCEDURE: Salpingectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Food Temperature and Diet Composition on Satiety, Satiety Hormones, Chewing Time and Neuronal Activity
Status: COMPLETED
Conditions: Obesity, Overweight
Interventions: OTHER: High Protein Meal at Cold Temperature|OTHER: High Protein Meal at Warm Temperarute|OTHER: High Protein Meal at Hot Temperature|OTHER: High Carbohydrate Meal at Cold Temperature|OTHER: High Carbohydrate Meal at Warm Temperature|OTHER: High Carbohydrate Meal at Hot Temperature|OTHER: High Fat Meal at Cold Temperature|OTHER: High Fat Meal at Warm Temperature|OTHER: High Fat Meal at Hot Temperature
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Surufatinib in Combination of Durvalumab and EP/EC in the Firstly-line Treatment of ES-SCLC
Status: NOT_YET_RECRUITING
Conditions: Extensive-stage Small-cell Lung Cancer
Interventions: DRUG: Surufatinib Durvalizumab EP/EC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chromatic Retinal Stimulation to Reduce Chronic Pain and Pain Sensitivity
Status: RECRUITING
Conditions: Chronic Low-back Pain|Chronic Pain|Fibromyalgia
Interventions: DEVICE: Green Light stimulation|DEVICE: Equal Energy White stimulation|DEVICE: S-cone modulating white light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Is End Tidal CO2 Level Elevation During Upper Endoscopy With CO2 Gas Insufflation Physiologically Significant
Status: COMPLETED
Conditions: Endoscopy
Interventions: OTHER: Air|OTHER: Carbon Dioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adding Adefovir Dipivoxil Versus Switching to Entecavir in Patients With Lamivudine-resistant Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: combination of lamivudine+adefovir vs entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurally Adjusted Ventilatory Assist (NAVA) in Ventilatory Care of Premature Infants
Status: COMPLETED
Conditions: Ventilation
Interventions: DEVICE: Neurally adjusted ventilatory assist, i-Servo, Maquet Nordic (Solna, Sweden)|DEVICE: Control group, ventilation with i-Servo or Stephanie
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Y-3 Intracalvariosseous Injection Versus Intravenous Injection in the Treatment of Acute Large Hemispheric Infarction
Status: RECRUITING
Conditions: Stroke, Acute Ischemic|Blood-Brain Barrier
Interventions: PROCEDURE: Y-3 ICO injection|DRUG: Y-3 intravenous injection|OTHER: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Doxycycline on Matrix Metalloproteinase Expression and Activity in the Abdominal Aneurysm
Status: COMPLETED
Conditions: Aortic Aneurysm, Abdominal
Interventions: DRUG: doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Attention Bias Modification Training in Youth With Subthreshold Impairing Anxiety
Status: COMPLETED
Conditions: Anxiety
Interventions: BEHAVIORAL: Attention Bias Modification|BEHAVIORAL: Placebo Attention Task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Third Ventriculostomy Versus Shunt for Children With Hydrocephalus
Status: COMPLETED
Conditions: Communicating Hydrocephalus
Interventions: PROCEDURE: Endoscopic third ventriculostomy (ETV)|PROCEDURE: Ventricular shunt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab in Combination With Plinabulin in Patients With Metastatic Non-Small Cell Lung Cancer (NSCLC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer Metastatic
Interventions: DRUG: Nivolumab + Plinabulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non Motors Aspects in De Novo Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease|Apathy
Interventions: DRUG: Rotigotine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BCI-Based Control for Ankle Exoskeleton T-FLEX: Comparison of Visual and Haptic Feedback With Stroke Survivors
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Implementation of a BCI system integrated to the T-FLEX lower-limb exoskeleton in post-stroke patients.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III
Status: COMPLETED
Conditions: COVID19|Diabetes Mellitus|Hypertension|Obesity|Overweight|Oxygen Saturation|Mortality|Inflammation
Interventions: DIETARY_SUPPLEMENT: Nutritional support system (NSS)|OTHER: Conventional nutritional support designed by hospital nutritionists
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Explore the Effect of Immune-induced Stereotactic Body Radiotherapy (SBRT) on Reversing Immunoresistance in Stage IIIc/IV Non-small Cell Lung Cancer (NSCLC)
Status: NOT_YET_RECRUITING
Conditions: Non-Small Cell Lung Cancer Without Mutation in Epidermal Growth Factor Receptor (Disorder)
Interventions: RADIATION: tereotactic body radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nurse-led Multidisciplinary Precision Care for Patients With Chronic Heart Failure
Status: ACTIVE_NOT_RECRUITING
Conditions: Nurse's Role|Multidisciplinary Communication|Chronic Heart Failure
Interventions: OTHER: multidisciplinary precision care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Dose Response Investigation of Docosahexaenoic Acid (DHA)
Status: RECRUITING
Conditions: Nutrition, Healthy
Interventions: DIETARY_SUPPLEMENT: docosahexaenoic acid (DHA)|DIETARY_SUPPLEMENT: soybean oil placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Melphalan, Lenalidomide, and Dexamethasone in Treating Patients With Primary Systemic Amyloidosis
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: dexamethasone|DRUG: lenalidomide|DRUG: melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III, Open-Label Study of Maintenance Lurbinectedin in Combination With Atezolizumab Compared With Atezolizumab in Participants With Extensive-Stage Small-Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Small-Cell Lung Cancer
Interventions: DRUG: Atezolizumab|DRUG: Lurbinectedin|DRUG: Carboplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Acute Effects Fortified Nutritional Supplementation on Childhood Cognition
Status: COMPLETED
Conditions: Cognitive Ability, General|Dietary Modification
Interventions: OTHER: SLOW Carbohydrate|OTHER: MEDIUM Carbohydrate|OTHER: FAST Carbohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Barrow Ruptured Aneurysm Trial
Status: UNKNOWN
Conditions: Ruptured Cerebral Aneurysm|Subarachnoid Hemorrhage (SAH)
Interventions: PROCEDURE: coil embolization|PROCEDURE: clip occlusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LIVing Donor Allograft for Anterior Cruciate Ligament Reconstruction Study
Status: RECRUITING
Conditions: ACL
Interventions: PROCEDURE: Endoscopic Anterior Cruciate Ligament reconstruction using living donor hamstring allograft from a parent donor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Evaluating Study of CT-P6 in Her2 Positive Early Breast Cancer
Status: COMPLETED
Conditions: HER2-positive Carcinoma of Breast
Interventions: DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Eat, Play, Sleep: A Text Message Approach to Promoting Health Behaviors for Cancer Survivors and Their Caregivers
Status: RECRUITING
Conditions: Cancer Survivors|Neoplasms
Interventions: BEHAVIORAL: Eat, Play, Sleep
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Compassionate Use (CU) Program of Odronextamab
Status: AVAILABLE
Conditions: Relapsed or Refractory (R/R) Follicular Lymphoma (FL)|Diffuse Large B-Cell Lymphoma (DLBCL)|B-Cell Non-Hodgkin Lymphoma (NHL)|High-Grade B-Cell Lymphoma (HGBCL)
Interventions: DRUG: Odronextamab
Study Type: EXPANDED_ACCESS
Clinical trial: Motor Plasticity, Intermittent Hypoxia and Sleep Apnea
Status: ACTIVE_NOT_RECRUITING
Conditions: Sleep Apnea, Obstructive|Spinal Cord Injuries|Hypoxia
Interventions: PROCEDURE: Induced Acute Intermittent Hypoxia (AIH)|DEVICE: AIH mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temporally Optimized Patterned Stimulation (TOPS®) Deep Brain Stimulation (DBS) for the Treatment of Parkinson's Disease
Status: TERMINATED
Conditions: Parkinson Disease
Interventions: DEVICE: TOPS1 DBS|DEVICE: TOPS2 DBS|DEVICE: TOPS3 DBS|DEVICE: Standard DBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Cholangiocarcinoma|Colorectal Cancer|Head and Neck Neoplasms|Lymphoma, Large-Cell, Anaplastic|Melanoma|Neuroendocrine Tumors|Non-Small Cell Lung Cancer|Ovarian Cancer|Pancreatic Cancer|Papillary Thyroid Cancer|Primary Brain Tumors|Renal Cell Carcinoma|Sarcomas|Salivary Gland Cancers|Adult Solid Tumor
Interventions: DRUG: Entrectinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk Neuroblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Ganglioneuroblastoma|Localized Resectable Neuroblastoma|Localized Unresectable Neuroblastoma|Neuroblastoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|DRUG: Carboplatin|OTHER: Clinical Observation|PROCEDURE: Computed Tomography|DRUG: Cyclophosphamide|DRUG: Doxorubicin Hydrochloride|DRUG: Etoposide|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Baduanjin Qigong Exercise on Fatigue in Patients With NSCLC Undergoing Adjuvant Chemotherapy
Status: UNKNOWN
Conditions: Fatigue
Interventions: OTHER: Baduanjin, a type of Qigong
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Bioavailability Study of Duloxetine Delayed-Release Capsules 60 mg Under Fasting Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Duloxetine|DRUG: Cymbalta®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: WECARE: A Behavioral Intervention for Dementia Caregivers
Status: ACTIVE_NOT_RECRUITING
Conditions: Caregiver Burden|Caregiver Stress Syndrome
Interventions: BEHAVIORAL: Wellness Enhancement for Caregivers (WECARE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety Study of a Modified XELOX Regimen in First-Line Treatment of Metastatic Colorectal Adenocarcinoma
Status: UNKNOWN
Conditions: Colorectal Adenocarcinoma
Interventions: DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetic and Preliminary Efficacy Study of AC0010 in Patients With EGFR T790M Positive NSCLC
Status: UNKNOWN
Conditions: Metastatic Non-small Cell Lung Cancer
Interventions: DRUG: AC0010
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online Delivery of Psychotherapy, Tailored to Patients' Suffering From Mental Health Problems Due to COVID-19
Status: COMPLETED
Conditions: Mental Health Issue|Covid19|Anxiety Disorders|Depression
Interventions: BEHAVIORAL: e-Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Traditional Chinese Medicine (TCM) for Temporomandibular Dysfunction (TMD): A Whole Systems Multi-site Trial
Status: COMPLETED
Conditions: Temporomandibular Dysfunction
Interventions: DRUG: TCM|BEHAVIORAL: Self-care for TMD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of NO Precursors on Physiological Responses to Exercise
Status: COMPLETED
Conditions: Physiology
Interventions: DIETARY_SUPPLEMENT: Nitrate|DIETARY_SUPPLEMENT: Nitrate and L-Arginine|DIETARY_SUPPLEMENT: Nitrate and L-Citrulline|DIETARY_SUPPLEMENT: Placebo|BIOLOGICAL: Evaluation of post-ischemic vascular reactivity|BIOLOGICAL: Neuromuscular evaluations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Duration of Analgesia With Dexmedetomidine and Ropivacaine in Brachial Plexus Block
Status: WITHDRAWN
Conditions: Analgesia|Pain, Acute|Peripheral Nerve Block
Interventions: DRUG: Dexmedetomidine|DRUG: ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of the Integra® Titan™ Modular Shoulder System Generation 2.5 for Primary Shoulder Joint Replacement
Status: TERMINATED
Conditions: Osteo Arthritis Shoulders|Traumatic Arthritis|Rheumatoid Arthritis
Interventions: DEVICE: Integra Titan Modular Shoulder System 2.5
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Secondary Prevention in Patients With Recurrent Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain, Recurrent
Interventions: BEHAVIORAL: Pain Neuroscience Education|OTHER: Exercise therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dynamic Cervical Implant vs. Anterior Cervical Discectomy and Fusion
Status: UNKNOWN
Conditions: Cervical Disc Prolapse
Interventions: PROCEDURE: Dynamic Cervical Implant|PROCEDURE: Anterior Cervical Discectomt and Fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cannabidiol and Cocaine Craving/Dependence
Status: COMPLETED
Conditions: Substance Use Disorder|Cocaine Dependence|Withdrawal From Addictive Substance; Detoxification
Interventions: DRUG: Cannabidiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: STAT-STatin and Aspirin in Trauma
Status: TERMINATED
Conditions: Wounds and Injuries|Venous Thromboembolism
Interventions: DRUG: Aspirin and Rosuvastatin|DRUG: Placebo (for Aspirin and Rosuvastatin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short Course Of Preoperative Radiotherapy in Head and Neck-, Trunk- and Extremity Soft Tissue Sarcomas
Status: RECRUITING
Conditions: Soft Tissue Sarcomas
Interventions: RADIATION: pre-operative radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-center, Non-randomized, Open-label Phase II Clinical Study on the Treatment of Newly Diagnosed Advanced Hodgkin's Lymphoma With PD-1 Antibody (Tislelizumab) Combined With AVD Regimen (Doxorubicin, Vindesine, Dacarbazine) Under the Guidance of PET/CT
Status: RECRUITING
Conditions: Hodgkin Lymphoma|Chemotherapy Effect
Interventions: DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spontaneous Breathing Trials Using Pressure-Support or T-Tube in Chronic Obstructive Pulmonary Disease Patients Weaning Mechanical Ventilation
Status: COMPLETED
Conditions: Weaning of Mechanical Ventilation|Chronic Obstructive Pulmonary Disease
Interventions: PROCEDURE: "T" Tube Spontaneous Breathing Trial|PROCEDURE: Pressure Support Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Zinc and Iron Bioavailability From Biofortified Pearl Millet
Status: COMPLETED
Conditions: Nutritional Deficiency
Interventions: OTHER: Pearl millet|OTHER: Biofortified pearl millet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Epidural Morphine for Postoperative Analgesia After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Adult Patients|Total Knee Arthroplasty|Epidural Analgesia|Femoral Nerve Block|Analgesic Adverse Reaction
Interventions: PROCEDURE: Epidural morphine|PROCEDURE: Epidural placebo|PROCEDURE: Single femoral nerve block|DRUG: Intravenous morphine analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 68Ga-TCR-FAPI PET/CT in Patients With Various Types of Cancer
Status: RECRUITING
Conditions: Malignant Tumor|Positron Emission Tomography|Fibroblast Activation Protein Inhibitor
Interventions: DIAGNOSTIC_TEST: 68Ga-TCR-FAPI PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I, Open-label, Dose-escalation, Safety and PK Study of AZD4877
Status: TERMINATED
Conditions: Lymphoma|NHL|Non-Hodgkin Lymphoma
Interventions: DRUG: AZD4877
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The STandard Versus ImAging SuBstrate Aided Ablation in Severe Left VEntricular Dysfunction VT.
Status: RECRUITING
Conditions: Cardiovascular Diseases
Interventions: OTHER: Incorporation of CT and/or c-MRI derived myocardial scar with 3D electroanatomical mapping (EAM).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of KLH-2109 in Uterine Fibroids Patient With Menorrhagia and Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Uterine Fibroids (MeSH Heading: Leiomyoma)
Interventions: DRUG: KLH-2109|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Proximal Tibia and Proximal Humerus Infusion Rates Using the NIO Intraosseous Device
Status: COMPLETED
Conditions: Intraosseous Access|Resuscitation
Interventions: DEVICE: NIO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tight Hemodynamic Control in Patients Who Are Chronically on Metoprolol
Status: TERMINATED
Conditions: Vascular Disease|Hypertension|Angina|Cardiac Disease
Interventions: DRUG: Esmolol|DRUG: Metoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Safety Of Abacavir And Lamivudine Administered Once-Daily As A Single Tablet Versus The Same Drugs Administered Twice-Daily As Separate Tablets (ALOHA Study)
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: Abacavir/Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Bone Marrow-Derived Mesenchymal Stem Cell Therapy for Idiopathic Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: BIOLOGICAL: Allogeneic bone marrow-derived MSCs (1 x 10 6 MSC/kg)|BIOLOGICAL: Allogeneic bone marrow-derived MSCs (3 x 10 6 MSC/kg)|BIOLOGICAL: Allogeneic bone marrow-derived MSCs (6 x 10 6 MSC/kg)|BIOLOGICAL: Allogeneic bone marrow-derived MSCs (10 x 10 6 MSC/kg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Stereotactic Body Radiotherapy (SBRT) for Localized Prostate Cancer: Cyberknife vs. VMAT
Status: UNKNOWN
Conditions: Prostatic Neoplasms
Interventions: RADIATION: Stereotactic Body Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bilateral TMS vs. Unilateral TMS
Status: UNKNOWN
Conditions: Neuropathic Pain|Orofacial Pain|Trigeminal Neuropathy
Interventions: DEVICE: Transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Kinesio Taping and Inhibitory Treatment Techniques
Status: SUSPENDED
Conditions: Fibromyalgia
Interventions: OTHER: Kinesio Taping and Inhibitory Treatment Techniques|OTHER: Exercise and Electrical Stimulation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Safety and Tolerability of CBL-514 Injection for Reducing Subcutaneous Fat (Stage 1)
Status: COMPLETED
Conditions: Subcutaneous Fat
Interventions: DRUG: CBL-514
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NAD Therapy for Improving Memory and Brain Blood Flow in Older Adults With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: DRUG: Niagen®|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing a ctDNA and PET-oriented Therapy in Patients With DLBCL A Multicenter, Open-label, Phase II Trial.
Status: RECRUITING
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: Acalabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ratio of Dietary Calcium to Magnesium on Cardiovascular Risk
Status: UNKNOWN
Conditions: Hypertension|Nutritional and Metabolic Diseases|Cardiovascular Risk Factor
Interventions: DIETARY_SUPPLEMENT: Individualized dosage of calcium and magnesium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Important Correlation Between Anxiety and Reflux Symptoms in Patients With Gastroesophageal Reflux Disease
Status: COMPLETED
Conditions: GERD - Gastro-Esophageal Reflux Disease|Anxiety Disorders
Interventions: DIAGNOSTIC_TEST: High-Resolution Manometry, Upper-GI endoscopy, pH-Impedance testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases Following Stereotactic Radiosurgery
Status: TERMINATED
Conditions: Breast Cancer|Brain Metastasis|Brain Cancer
Interventions: DRUG: T-DM1|DRUG: TMZ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Response of Patients With Chronic, Staphylococcus Aureus-infected Wounds
Status: COMPLETED
Conditions: Diabetic Foot|Foot Ulcer|Leg Ulcer|Bacteremia|Infection
Interventions: BIOLOGICAL: Antibody assays for S. aureus|BIOLOGICAL: Basic blood work
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase III to Evaluate Patient´s Preference of Subcutaneous Trastuzumab vs Intravenous in HER2+ Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab Injectable Solution|DRUG: Trastuzumab Injectable Product|DRUG: Trastuzumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Frequency of Genetic Sucrase-Isomaltase Deficiency Genotypes, and the Efficacy and Safety of Sucraid® (Sacrosidase) Oral Solution in Subjects With Chronic Diarrhea and Sucrase Deficiency
Status: WITHDRAWN
Conditions: Genetic Sucrase-Isomaltase Deficiency
Interventions: DRUG: Sucraid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Early Limited Formula on Total Serum Bilirubin Among Newborns With Hyperbilirubinemia
Status: WITHDRAWN
Conditions: Hyperbilirubinemia, Neonatal
Interventions: DIETARY_SUPPLEMENT: Nutramigen Infant Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hemodynamic Parameters and Cardiac Enzyme Levels in Patients Undergoing General Anesthesia
Status: COMPLETED
Conditions: Anesthesia,General|Cardiac Event
Interventions: OTHER: target controlled infusion - total intravenous general anesthesia|OTHER: sevoflurane based balanced general anesthesia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transcranial Static Magnetic Field Stimulation (tSMS) in Amyotrophic Lateral Sclerosis (ALS).
Status: UNKNOWN
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DEVICE: tSMS|DEVICE: sham tSMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Pre-Sedation Virtual Reality Game on Post-Discharge Negative Behaviors in the Pediatric Emergency Department
Status: COMPLETED
Conditions: Behavior, Child|Anxiety
Interventions: OTHER: Virtual Reality Game
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Determine the Safety, Tolerability and Efficacy NW-3509A in Patients With Chronic Schizophrenia
Status: COMPLETED
Conditions: Chronic Schizophrenia
Interventions: DRUG: NW-3509A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Will Veterans Engage in Prevention After HRA-guided Shared Decision Making?
Status: COMPLETED
Conditions: Health Risk Appraisal|Heart Disease|Prevention
Interventions: BEHAVIORAL: Shared decision making with a Prevention Coach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effectiveness Evaluation of a Self-management Program for Prostate Cancer Survivors
Status: RECRUITING
Conditions: Prostatic Neoplasms|Self-Management
Interventions: BEHAVIORAL: Self-management program|OTHER: Information package
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Melatonin and Radiation Therapy in Treating Patients With Brain Metastases
Status: COMPLETED
Conditions: Metastatic Cancer|Radiation Toxicity|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: therapeutic melatonin|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Osseodensification Versus Conventional Drilling for Implant Site Preparation
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Implant Failed|Jaw, Edentulous, Partially|Edentulous Alveolar Ridge|Osseointegration Failure of Dental Implant
Interventions: PROCEDURE: Osseodensification osteotomy preparation|PROCEDURE: Standardized osteotomy preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance (MR) Imaging With Hyperpolarized Pyruvate (HP) (13C) in Castration-Resistant Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Pyruvate (13C)|DEVICE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase III, Evaluate Noninferiority Between Levobupivacaine and Bupivacaine in Spinal Anesthesia.
Status: WITHDRAWN
Conditions: Orthopedic Disorder of Spine
Interventions: DRUG: Levobupivacaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot: Intraoperative TAP Block and Post-operative Pain Control for Minimally Invasive Hysterectomy for Endometrial Cancer
Status: ENROLLING_BY_INVITATION
Conditions: Post Operative Pain|Gynecologic Cancer
Interventions: DRUG: Liposomal bupivacaine|DRUG: Bupivacain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Re-EValuating the Inhibition of Stress Erosions (REVISE) - COVID-19 Cohort Study
Status: RECRUITING
Conditions: COVID-19|GastroIntestinal Bleeding
Interventions: OTHER: Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial (NCT03374800)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of Ascertaining Individual Preferences for Loved One's Role in End-of-Life
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis|GI Cancer|Pancreatic Cancer
Interventions: OTHER: TAILORED Patient Family Decision Making|OTHER: standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Contrast-Enhanced Ultrasound for the Prediction of Bile Duct Cancer Response to Radioembolization Treatment
Status: RECRUITING
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DRUG: Perflutren Protein-Type A Microspheres|PROCEDURE: Contrast-Enhanced Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Investigation of the Effects of CGF and A-PRF on Pain, Edema and Trismus After Impacted Lower Third Molar Surgery
Status: COMPLETED
Conditions: Trismus|Edema|Pain|Post-Op Complication
Interventions: OTHER: Concentrated Growth Factor (CGF)|OTHER: Advanced Platelet Rich Fibrin (A-PRF)|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study in Healthy Volunteers for Empagliflozin/Metformin Fixed Dose Combination Compared to Separate Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Empagliflozin 2.5 mg|DRUG: Empagliflozin 10 mg|DRUG: Metformin 500 mg|DRUG: Empagliflozin/Metformin FDC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impaired Secretory IgA and Mucosal Immunity in Cystic Fibrosis
Status: UNKNOWN
Conditions: Cystic Fibrosis
Interventions: OTHER: Lung explants|OTHER: Sputum, nasal fluid and serum|PROCEDURE: Bronchoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunogenicity, Safety, Tolerability of a Plant-Made H5 VLP Influenza Vaccine
Status: COMPLETED
Conditions: Virus Diseases|RNA Virus Infections|Respiratory Tract Diseases|Respiratory Tract Infections
Interventions: BIOLOGICAL: 20 micrograms dose H5 VLP|BIOLOGICAL: 30 micrograms dose H5 VLP|BIOLOGICAL: 45 micrograms dose H5 VLP|BIOLOGICAL: 45 micrograms non-adjuvanted H5 VLP|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: System Accuracy and User Performance of Blood Glucose Monitoring Systems for Self-Testing in Managing Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes
Interventions: DEVICE: Blood glucose monitoring system (Omnitest 3)|DEVICE: Blood glucose monitoring system (Omnitest 5)|DEVICE: Blood glucose monitoring system (Omnitest 5D)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Tolerability, Pharmacokinetics and Pharmacodynamics of Ascending Single and Repeated Doses of SAR444336 in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: SAR444336|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: 577nm Micropulse Laser vs Half-dose Photodynamic Therapy on Acute Central Serous Chorioretinopathy
Status: COMPLETED
Conditions: Acute Central Serous Chorioretinopathy
Interventions: DEVICE: 577-MPL|DEVICE: HD-PDT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of MK0928 in Healthy Adult Volunteers in a Model of Insomnia (0928-006)(COMPLETED)
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: gaboxadol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel fNIRS Neurofeedback Intervention for Enhancement of Working Memory in Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: ADHD
Interventions: BEHAVIORAL: Neurofeedback|BEHAVIORAL: Cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Potassium Containing Salt-Substitute in Hemodialysis-Dependent End Stage Kidney Disease
Status: NOT_YET_RECRUITING
Conditions: End Stage Kidney Disease
Interventions: DIETARY_SUPPLEMENT: Standard Table Salt|DIETARY_SUPPLEMENT: Salt Substitute
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION