pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Combination of Curcumin and Berberine Therapy in the Treatment of Post Acute Diverticulitis (SUDD)
Status: RECRUITING
Conditions: Diverticulitis
Interventions: COMBINATION_PRODUCT: Curcumin-Berberine (coptis)|COMBINATION_PRODUCT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Transplantation Compared With Standard Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia in First Remission
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: sargramostim|DRUG: asparaginase|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: dexamethasone|DRUG: etoposide|DRUG: imatinib mesylate|DRUG: leucovorin calcium|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: prednisone|DRUG: thioguanine|DRUG: vincristine sulfate|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selexipag (ACT-293987) in Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Selexipag|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study to Evaluate the Efficacy and Safety of the Fixed-dose Combination of Estradiol / Dydrogesterone in Perimenopausal Women
Status: UNKNOWN
Conditions: Perimenopausal Disorder|Hot Flashes
Interventions: DRUG: Femoston® 1, Femoston® 2|DRUG: Duphaston|DRUG: Klimadynon|DRUG: Divigel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individual Risk Profiles for Adverse Drug Reactions in Geriatric Patients
Status: NOT_YET_RECRUITING
Conditions: Polypharmacy|Pharmacogenetics|Pharmacogenomic Testing|Drug-Related Side Effects and Adverse Reactions
Interventions: GENETIC: Pharmacogenomic testing of a panel of important pharmacogenes to detect genetic variants and evaluate the association between genetically predicted and measured drug metabolism|OTHER: Adverse Drug Reaction detection|OTHER: Falls Efficacy Scale International (FES-I)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Different Combinations of Zonisamide-CR Plus Bupropion-SR to Treat Uncomplicated Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Zonisamide CR and Bupropion SR|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence, Prevalence, and Symptom Burden Associated With Advanced Renal Cell Carcinoma in Commercially Insured Population (IHCIS)
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Targeted agents indicated in management of advanced/metastatic RCC (sunitinib, sorafenib, bevacizumab, and pazopanib)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Safety and Efficacy of MY008211A in in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)
Status: NOT_YET_RECRUITING
Conditions: Paroxysmal Nocturnal Hemoglobinuria (PNH)
Interventions: DRUG: MY008211A tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Octreotide in the Prevention of Postoperative Complications After Pancreaticoduodenectomy
Status: COMPLETED
Conditions: Periampullary Carcinoma Resectable
Interventions: DRUG: Octreotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Exercise and Cognitive Training in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: BEHAVIORAL: Treadmill training with aerobic exercise|BEHAVIORAL: Memory training with computerized memory program|BEHAVIORAL: Combination of treadmill training and computerized memory
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of MK-8266 in Elderly Participants With High Blood Pressure (MK-8266-003)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: MK-8266|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Diagnosis of Diabetes Mellitus in Patients With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis|Diabetes Mellitus
Interventions: DRUG: Repaglinide|DRUG: short-acting Insulin (Actrapid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pain After Root Canal Preparation Using Different Engine-driven Systems
Status: COMPLETED
Conditions: Asymptomatic Molar Teeth With Periapical Lesions
Interventions: OTHER: Protaper Universal instruments|OTHER: Reciproc Blue instruments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of High-intensity NPPV and Low-intensity NPPV in Patients With Chronic Hypercapnic COPD
Status: UNKNOWN
Conditions: COPD|Hypercapnic Respiratory Failure
Interventions: DEVICE: Noninvasive positive pressure ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alzheimer's Disease Neuroimaging Initiative 4
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Alzheimer Disease|Dementia
Interventions: RADIATION: Neuraceq|RADIATION: Amyvid|RADIATION: Tauvid|RADIATION: MK-6240|RADIATION: NAV4694|RADIATION: PI-2620
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dexmedetomidine As An Adjuvant To Bupivacaine 0.1% in Labor Analgesia
Status: COMPLETED
Conditions: Labor Analgesia|Labor Pain
Interventions: DRUG: Dexmedetomidine|DRUG: Bupivacain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Dose-Finding Study of CD07805/47 Topical Gel in Subjects With Erythematotelangiectatic Rosacea
Status: COMPLETED
Conditions: Erythematotelangiectatic Rosacea
Interventions: DRUG: CD07805/47|DRUG: CD07805/47|DRUG: CD07805/47|DRUG: CD07805/47 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cold Apheresis Platelets in PAS
Status: UNKNOWN
Conditions: Platelet Transfusion
Interventions: PROCEDURE: Apheresis platelet collection|OTHER: Refrigerated storage of apheresis platelets in PAS/plasma|RADIATION: Infusion of aliquot of autologous radiolabeled platelets|OTHER: In vitro tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hypertension Management in Cancer Patients
Status: TERMINATED
Conditions: Blood Pressure|Hypertension|Cancer|Cancer, Breast|Cancer of Prostate|CLL|Hematopoietic Malignancy
Interventions: OTHER: Automated Messaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: IN-OFFICE TOOTH BLEACHING WITH 37% CARBAMIDE PEROXIDE
Status: COMPLETED
Conditions: Tooth Sensitivity
Interventions: DRUG: 37% Carbamide Peroxide|DRUG: 35% hydrogen Peroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Single-center Clinical Trial of Bortezomib in Management of Immune Thrombocytopenia (ITP)
Status: UNKNOWN
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: End-Expiratory Lung Volume in Children Awakening From Propofol Anesthesia
Status: RECRUITING
Conditions: Atelectasis, Postoperative Pulmonary
Interventions: OTHER: Head elevation_H|OTHER: Supine_H|OTHER: Head elevation_L|OTHER: Supine_L
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Induction Chemotherapy Followed by IMRT With or Without Concurrent Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Docetaxel,Cisplatin,Fluorouracil|RADIATION: Intensity-modulated radiation therapy (IMRT)|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an "Opt-Out" Inpatient Smoking Cessation Service on Smoking Behavior Study #1
Status: ACTIVE_NOT_RECRUITING
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Enhanced Care|BEHAVIORAL: Basic Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate
Status: COMPLETED
Conditions: Cleft Palate
Interventions: PROCEDURE: sampling mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Patient Education in Rheumatoid Arthritis and Osteoarthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Osteoarthritis
Interventions: BEHAVIORAL: Arthritis Self-Management Program|BEHAVIORAL: SMART Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venlafaxine Hydrochloride 150 mg Extended-Release Capsules Sprinkle Study
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Venlafaxine Hydrochloride|DRUG: Effexor® XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Improving Skin Cancer Management With Artificial Intelligence (04.17 SMARTI)
Status: COMPLETED
Conditions: Skin Cancer|Melanoma (Skin)
Interventions: DEVICE: Molemap Skin Cancer Triage Artificial Intelligence Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Quality of Life Changes in Puerto Rican Subjects With Active Rheumatoid Arthritis Treated With Humira
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Humira (adalimumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19: Healthcare Worker Bioresource: Immune Protection and Pathogenesis in SARS-CoV-2
Status: UNKNOWN
Conditions: Health Care Worker Patient Transmission|Coronavirus|Coronavirus Infections|Immunological Abnormality
Interventions: DIAGNOSTIC_TEST: COPAN swabbing and blood sample collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Plasma and Abscess Fluid Pharmacokinetics of Cefpirome and Moxifloxacin After Single and Multiple Dose Administration
Status: COMPLETED
Conditions: Abscess|Cysts
Interventions: DRUG: cefpirome and moxifloxacin administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose:
Clinical trial: The Efficacy and Safety of Pregabalin Release Tablets for the Treatment of Fibromyalgia
Status: UNKNOWN
Conditions: Fibromyalgia
Interventions: DRUG: Pregabalin Release Tablets|DRUG: Pregabalin Release Tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: M9241 in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer or Intrahepatic Cholangiocarcinoma
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer (Mcrc)|Intrahepatic Cholangiocarcinoma (Icc)|Colorectal Cancer|Colorectal Neoplasms|Cholangiocarcinoma|Intrahepatic Bile Duct Cancer|Bile Duct Cancer|Bile Duct Neoplasms
Interventions: DRUG: Floxuridine|DRUG: 5-Fluorouracil|DRUG: Irinotecan|DEVICE: Intera 3000 Hepatic Artery Infusion Pump (HAIP)|DRUG: Oxaliplatin|DRUG: Leucovorin|DRUG: M9241|DRUG: Gemcitabine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propofol-butorphanol Anesthesia During Uterine Curettage
Status: COMPLETED
Conditions: Abortion|Curettage
Interventions: DRUG: Fentanyl Citrate|DRUG: Butorphanol Tartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Feasibility and Advantages of Painless Indwelling Catheter in Uniportal VATS Lobectomy of Lung Cancer
Status: UNKNOWN
Conditions: Urethral Catheter; Complications
Interventions: PROCEDURE: painless indwelling catheter|PROCEDURE: indwelling catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Contrast Nephropathy Prevention With N-Acetylcysteine in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Contrast-Induced Nephropathy|Acute Myocardial Infarction
Interventions: DRUG: intravenous and oral N-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: The Plasma Diafiltration Therapy of Hepatic Failure
Status: UNKNOWN
Conditions: Hepatic Failure|Plasma Exchange
Interventions: PROCEDURE: simple plasma exchange|PROCEDURE: conventional PDF treatment group|PROCEDURE: less plasma PDF treatment group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of the Cardiac Phenotype of Friedreich's Ataxia (FRDA)
Status: RECRUITING
Conditions: Friedreich's Ataxia
Interventions: PROCEDURE: Cardiac magnetic resonance imaging (CMR)|PROCEDURE: Exercise-stress test|PROCEDURE: Echocardiogram (ECHO)|PROCEDURE: Cardiac-related blood studies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Strategies for Transfusion of Platelets (SToP)
Status: TERMINATED
Conditions: Thrombocytopenia
Interventions: PROCEDURE: low dose of 2.25 x 10^11 platelets/transfusion (range 1.5 to 2.9)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Retrospective Study of Toxicity and Outcome of High Dose Chemotherapy With Autologous Stem Cell Transplant in Patients With Hodgkin Lymphoma (HL).
Status: COMPLETED
Conditions: Hodgkin Lymphoma
Interventions: PROCEDURE: Autologous stem cell transplant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Efficacy of Single Oral Dose Fluconazole and Itraconazole in Patients With Pityriasis Versicolor
Status: COMPLETED
Conditions: Tinea Versicolor
Interventions: DRUG: Fluconazole|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Improving the Collaborative Health of Minority COVID-19 Survivor and Carepartner Dyads
Status: RECRUITING
Conditions: SARS- CoV-2|Cardiovascular Diseases|Chronic Kidney Diseases|Diabetes Mellitus, Type 2|Chronic Disease|Stroke
Interventions: BEHAVIORAL: Integrating Community-based Intervention Under Nurse Guidance with Families (iCINGS FAM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Safety of the Treatment of Benign Prostatic Hyperplasia by High Intensity Focused Ultrasound.
Status: UNKNOWN
Conditions: Benign Prostatic Hyperplasia
Interventions: DEVICE: HIFU treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of InnoSlim® on Blood Sugar and Blood Lipids Regulation in Humans
Status: UNKNOWN
Conditions: Hyperlipidemia
Interventions: DIETARY_SUPPLEMENT: InnoSlim®|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Significance of Duration of Maintenance Therapy With Rituximab in Non-Hodgkin Lymphomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Follicular Lymphomas|Immunocytomas|Marginal Zone Lymphomas|Mantle-Cell Lymphomas|Lymphocytic Lymphoma|Non-Hodgkin's Lymphoma
Interventions: DRUG: Rituximab|DRUG: Rituximab / observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ELICIT 2.0: Pilot Study of the Effect of Maternal Protein Supplementation During Lactation on Childhood Growth
Status: UNKNOWN
Conditions: Growth Failure|Stunting|Malnutrition|Protein Malnutrition
Interventions: DIETARY_SUPPLEMENT: Plumpy'Mum
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Breath Exercise Training on Postoperative Pain, Anxiety, and Nausea-Vomiting in General Surgery Patients
Status: COMPLETED
Conditions: Postoperative Pain, Acute|Postoperative Nausea and Vomiting|Patient Relations, Nurse
Interventions: OTHER: Breath Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Open-Label, 2 Treatment Period,Study To Study The Drug Interaction Between Repeated Doses Of Itraconazole And Single Dose Pharmacokinetics (PK) Of PF-06648671 In Healthy Adults.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06648671|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation Effect of Crocina on The Cellular Immune Responses in Osteoarthritis Patients
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Crocin|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab (MEDI4736) With Cetuximab in Previously Treated Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Head and Neck Cancer|Head and Neck Cancer|Head and Neck Neoplasms|Metastatic Cancer
Interventions: DRUG: Durvalumab|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Chemotherapy Plus Apatinib as Second-line Therapy in Metastatic Colorectal Cancer
Status: WITHDRAWN
Conditions: Colorectal Cancer|Chemotherapy|Angiogenesis
Interventions: DRUG: Chemotherapy + Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic or Preemptive Entecavir in Patients With Colorectal Cancer Who Are Inactive Hepatitis B Carriers
Status: UNKNOWN
Conditions: Colorectal Neoplasms
Interventions: DRUG: Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a Combination of GSK1795091 and Immunotherapies in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: GSK1795091|DRUG: GSK3174998|DRUG: GSK3359609|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trace Element Replenishment Study in Hemodialysis Patients
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DIETARY_SUPPLEMENT: Low dose: supplemental zinc, selenium and vitamin E|DIETARY_SUPPLEMENT: Standard renal vitamin: B and C renal vitamin|DIETARY_SUPPLEMENT: Medium dose: supplemental zinc, selenium and vitamin E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Microbiota Changes Induced by Microencapsulated Sodium Butyrate in Patients With Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Butyrate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Recombinant Human Granulocyte Colony- Stimulating Factor on CD11b in Septic Neonates
Status: COMPLETED
Conditions: Neonatal Sepsis
Interventions: DRUG: rh-GCSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bilateral Endoscopic Thoracic T3 Sympathectomy Versus T3 Radiofrequency Ablation for Primary Palmar Hyperhidrosis
Status: NOT_YET_RECRUITING
Conditions: Primary Palmar Hyperhydrosis
Interventions: PROCEDURE: Endoscopic thoracic T3 sympathectomy|PROCEDURE: ThoracicT3 radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HOME FIRST Pilot: a Study of Early Supported Discharge in Patients With Lower Respiratory Tract Infections
Status: COMPLETED
Conditions: Community Acquired Pneumonia|Hospital Acquired Pneumonia|Lower Respiratory Tract Infection
Interventions: OTHER: HOMEFIRST|OTHER: Standard Hospital Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of 4 Weeks Treatment With Acipimox in Patients With Chronic Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: acipimox|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: STEMI Treatment Optimization by Ischemic Postconditioning and IVUS Guidance
Status: RECRUITING
Conditions: ST Elevation Myocardial Infarction
Interventions: PROCEDURE: PCI + Ischemic conditioning|PROCEDURE: Stent with ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label, Single Arm Study of the Efficacy of Accelerated Intermittent Theta Burst Stimulation in Schizophrenia Patients With Persistent Negative Symptoms
Status: RECRUITING
Conditions: Schizophrenia; Negative Type
Interventions: DEVICE: Accelerated iTBS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Oxygen Optimization in Severe TBI, Phase 3
Status: RECRUITING
Conditions: Brain Injuries, Traumatic
Interventions: OTHER: ICP + PbtO2 guided management strategy|OTHER: ICP guided management strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Quality of Recovery Between Desflurane & Isoflurane in Eye Surgery Patients at Dr George Mukhari Acad Hospital
Status: COMPLETED
Conditions: Quality of Recovery|Anesthesia Recovery Period
Interventions: DRUG: Desflurane|DRUG: Isoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Vitamin D3 Supplementation in Non-Sjogren Dry Eye Patients With Low Serum Vitamin D Level
Status: COMPLETED
Conditions: Dry Eye Syndromes|Hypovitaminosis D
Interventions: DRUG: Vitamin D|DRUG: Artificial tear
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Intradialytic Amino Acid Supplementation to Vitalize End-stage Kidney Disease Patients on Hemodialysis
Status: NOT_YET_RECRUITING
Conditions: End Stage Renal Disease
Interventions: DRUG: Valine|DRUG: EEA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization of Psoriatic and Seronegative Rheumatoid Arthritis Patients Selection and Treatment Outcomes of Biologic Therapies.
Status: RECRUITING
Conditions: Psoriatic Arthritis|Rheumatoid Arthritis
Interventions: OTHER: Phenotyping of synovial immune and stromal cells
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 1 Study To Test the Bioequivalence Between Two 25 mg Tablets vs. One 50 mg Tablet Under Fast/Fed Condition and Evaluate Food Effect of Desvenlafaxine Succinate Sustained Release (DVS SR)
Status: COMPLETED
Conditions: Depression - Major Depressive Disorder
Interventions: DRUG: desvenlafaxine succinate sustained release|DRUG: desvenlafaxine succinate sustained release|DRUG: desvenlafaxine succinate sustained release|DRUG: desvenlafaxine succinate sustained release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improved Bowel Cleansing Method for Colonoscopy Based on High Risk Population of Bowel Preparation
Status: UNKNOWN
Conditions: Bowel Preparation Before Colonoscopy
Interventions: DRUG: PEG+lactulose|DRUG: CSP＋lactulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Effect of Intravenous Metoprolol Combining RIC on Myocardial Protection in STEMI Patients
Status: COMPLETED
Conditions: Anterior Myocardial Infarction|Heart Failure
Interventions: DRUG: intravenous Placebo|DRUG: Metoprolol Injectable Product|DEVICE: Romote Ischemic Conditioning (RIC)|COMBINATION_PRODUCT: Metoprolol & RIC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liquid Biopsy for the Diagnosis of Intestinal-type Adenocarcinoma of the Ethmoid (BLADE)
Status: NOT_YET_RECRUITING
Conditions: Ethmoid Sinus Tumor|Adenocarcinoma|Circulating Tumor Cell
Interventions: DIAGNOSTIC_TEST: Liquid biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: TCM Therapy Program Impact on Breast Cancer Patients' Vital Energy
Status: RECRUITING
Conditions: Breast Cancer|Neoplasm, Breast|Patient Participation|Mental Health Issue
Interventions: BEHAVIORAL: Traditional Chinese Medicine Therapy Program for Reinforcing Vital Energy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Interventions to Improve Colon Cancer Screening in Poor Rural Iowa Counties
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BEHAVIORAL: Physician chart reminder|BEHAVIORAL: chart reminder, educational mat'ls, FIT|BEHAVIORAL: CR,ed mat'ls, FIT, phone call
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: The Use of Focused Ultrasound and DCE K-trans Imaging to Evaluate Permeability of the Blood-Brain Barrier
Status: ENROLLING_BY_INVITATION
Conditions: Low Grade Glioma of Brain
Interventions: OTHER: Focused Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Adverse Cardiac Events in COPD
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|Cardiovascular Diseases
Interventions: DRUG: Bisoprolol|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare Safety and Efficacy of Prograf + Myfortic and Advagraf + Myfortic in Liver Transplantation Patients
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: DRUG: Prograf|DRUG: Advagraf|DRUG: Myfortic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estetrol for the Treatment of Female Sexual Arousal Disorder in Postmenopausal Women
Status: RECRUITING
Conditions: Sexual Dysfunction, Physiological
Interventions: DRUG: 20 mg estetrol monohydrate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cefprozil for Oral Suspension 250 mg/5 mL, Fasting
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cefprozil for oral suspension 250 mg/5 mL|DRUG: CEFZIL® for Oral Suspension 250 mg/5mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Investigate Safety and Tolerability of a Single Dose of AZD6482
Status: COMPLETED
Conditions: Antiplatelet Effect
Interventions: DRUG: AZD6482|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Solid Tumors in RASopathies
Status: RECRUITING
Conditions: RASopathy|Costello Syndrome|Cardio-Facio-Cutaneous Syndrome|Noonan Syndrome
Interventions: DIAGNOSTIC_TEST: Molecular characterization of solid tumor in RASopathies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cholecalciferol Supplementation, Muscle Strength
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DRUG: Cholecalciferol|DRUG: Lactose placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Itacitinib for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Acute Lymphocytic Leukemia|Myelodysplastic Syndromes|Non-Hodgkin Lymphoma|Hodgkin Disease
Interventions: PROCEDURE: Stem cell transplantation|DRUG: Itacitinib|OTHER: Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT)|OTHER: Human Activity Profile
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of SofWave Treatment to Lift the Upper Lip and Improve the Peri-Oral Rhytids
Status: ENROLLING_BY_INVITATION
Conditions: Rhytides|Wrinkle
Interventions: DEVICE: Sofwave
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EUS-guided Fine Needle Aspiration (FNA) With and Without the Use of a Stylet
Status: COMPLETED
Conditions: Biopsy, Fine-Needle|Biopsy, Fine-Needle/Methods|Endosonography
Interventions: DEVICE: FNA with and without a stylet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Assess the Long-Term Safety and Efficacy of Donidalorsen in the Prophylactic Treatment of Hereditary Angioedema (HAE)
Status: RECRUITING
Conditions: Hereditary Angioedema
Interventions: DRUG: Donidalorsen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lower Extremity Splinting to Manage Pain and Sleep Disturbances Associated With HIV/AIDS Related Peripheral Neuropathy
Status: COMPLETED
Conditions: HIV|AIDS|Peripheral Neuropathy|Pain|Sleep
Interventions: DEVICE: Splinting application to the lower extremities|DEVICE: Splint liner application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Psychological Sequelae After Sudden Cardiac Death in the Patient and His Relatives
Status: COMPLETED
Conditions: Post Traumatic Stress Disorder|Resuscitated Sudden Cardiac Death
Interventions: BEHAVIORAL: SASRQ questionnaire|BEHAVIORAL: PCL-5 with LEC-5 questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Oral Chemotherapy And Platinum With Radiotherapy Followed Or Not By Consolidation With The Same Chemotherapy In Locally Advanced Non Small Cell Lung Cancer
Status: COMPLETED
Conditions: NSCLC
Interventions: DRUG: Oral Vinorelbine and cisplatin with concomitant radiotherapy 66 Gy (total dose)|DRUG: Oral Vinorelbine and cisplatin with concomitant radiotherapy 66 Gy (total dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Colistin Doses on Clinical Outcome of Pediatric Cancer Patients With Gram Negative Infections
Status: COMPLETED
Conditions: Gram-Negative Bacterial Infections|Pediatric Cancer|Colistin|Colistin Adverse Reaction|MIC
Interventions: DRUG: Colistimethate Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Upper GI Ulceration Induced by PL2200 Versus Aspirin in At-Risk Subjects
Status: COMPLETED
Conditions: Gastroduodenal Ulceration
Interventions: DRUG: PL2200|DRUG: Aspirin tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Hepatocellular Carcinoma: Long-Acting Somatostatin Plus Percutaneous Ethanol Instillation (PEI) Versus Long-Acting Somatostatin Alone
Status: UNKNOWN
Conditions: Carcinoma, Hepatocellular
Interventions: PROCEDURE: percutaneous ethanol instillation (PEI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intranasal Insulin on Neurocognitive Function in Euthymic Patients With Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Intranasal Insulin|DRUG: Diluent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: EVOLUTION® Duodenal Stent for Duodenal or Gastric Outlet Obstruction Caused by Malignant Neoplasms
Status: COMPLETED
Conditions: Duodenal Obstruction|Gastric Outlet Obstruction
Interventions: DEVICE: EVOLUTION® Duodenal Stent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of an Intensive Weight Loss Program for Obstructive Sleep Apnea Syndrome (OSAS) Treatment.
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive|Obesity
Interventions: BEHAVIORAL: Intensive weight loss program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lysosomal Storage Disease: Health, Development, and Functional Outcome Surveillance in Preschool Children
Status: COMPLETED
Conditions: Mucopolysaccharidosis Type I (MPS I)|Mucopolysaccharidosis Type II (MPS II)|Mucopolysaccharidosis Type III (MPS III)|Mucopolysaccharidosis Type VI (MPS VI)|Krabbe Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: EXploring Immune-related Adverse Events of Immune checkpoinT Inhibitors Using VigiBase, the WHO Pharmacovigilance Database
Status: COMPLETED
Conditions: Cancer|Immune-related Adverse Event|Immune Checkpoint Inhibitor-Related Myocarditis
Interventions: DRUG: Immune checkpoint inhibitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vaginal Misoprostol In Management Of First Trimester Missed Abortion.
Status: COMPLETED
Conditions: Abortion, Missed
Interventions: DRUG: vaginal misoprostol|DRUG: buccal/sublingual misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Different Natural Surfactants in the Treatment of Pulmonary Hemorrhage
Status: COMPLETED
Conditions: Pulmonary Hemorrhage
Interventions: DRUG: Poractant alfa|DRUG: Beractant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of RIC on Cognitive Function and Blood Oxygen Levels in Unacclimatized Adult at High Altitude
Status: UNKNOWN
Conditions: Adult
Interventions: DEVICE: RIC|DEVICE: sham RIC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Non-invasive Measurement of the Hypotension Prediction Index for the Reduction of Intraoperative Hypotension
Status: NOT_YET_RECRUITING
Conditions: Intraoperative Hypotension|Acute Kidney Injury|Myocardial Injury After Non-cardiac Surgery
Interventions: DEVICE: GDT-based hemodynamic management based on Clearsight device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Safety and Pharmacokinetics of Single Ascending Doses and Multiple Ascending Doses of CS6253 in Healthy Volunteers
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer's Disease
Interventions: DRUG: CS6253 Solution for Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Study to Assess Efficacy and Safety of 4 Doses of LAS100977 in Chronic Obstructive Pulmonary Disease (COPD) Population
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: LAS100977|DRUG: LAS100977|DRUG: LAS100977|DRUG: LAS100977|DRUG: Reference|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tivantinib in Treating Patients With Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Hormone-Resistant Prostate Cancer|Prostate Adenocarcinoma|Recurrent Prostate Carcinoma|Stage IV Prostate Cancer
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Placebo|DRUG: Tivantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Real World Evidence for the Cycle of Neoadjuvant Chemotherapy in Gastric Cancer With Shared Decision Making
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: NACT|PROCEDURE: SDM|PROCEDURE: Surgery|DRUG: ACT|OTHER: Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MuLtibranchEd Graft for OPen RepAir of ThoRacoabdominal Aneurysms
Status: COMPLETED
Conditions: Aneurysm Abdominal|Aneurysm Thoracic
Interventions: DEVICE: branched prosthesis for surgical treatment of thoraco-abdominal aortic aneurysms
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Women-Focused Cardiovascular Rehabilitation Program on Adherence, Health Related Physical Fitness, and Quality of Life
Status: NOT_YET_RECRUITING
Conditions: Cardiovascular Diseases
Interventions: BEHAVIORAL: Individualized Counselling Sessions|BEHAVIORAL: Educational Women-Focused Sessions|BEHAVIORAL: Supervised Exercise Training Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The DEtermining Statin Intolerance FOr Rosuvastatin (DESIFOR) Trial
Status: UNKNOWN
Conditions: Cardiovascular Risk Factor|Cardiovascular Diseases|Adverse Effect
Interventions: DRUG: Rosuvastatin 20mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of VI-0521 (Qsymia®) on Glomerular Filtration Rate (GFR) in Overweight or Obese Healthy Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Qsymia|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Preliminary Effects of the Resilience-based, Energy Management to Enhance Wellbeing in Systemic Sclerosis (RENEW) Intervention
Status: COMPLETED
Conditions: Scleroderma
Interventions: BEHAVIORAL: Resilience-based, Energy Management to Enhance Wellbeing (RENEW)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PK Study of PT003 and PT001 in Japanese Healthy Subjects
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Glycopyrronium and Formoterol Fumarate (GFF) Dose 1|DRUG: Glycopyrronium and Formoterol Fumarate (GFF) Dose 2|DRUG: Glycopyrronium (GP) Dose 1|DRUG: Glycopyrronium (GP) Dose 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Treatment of Temporomandibular Joint in Patients With Chronic Migraine and Temporomandibular Disorders
Status: COMPLETED
Conditions: Chronic Migraine|Temporomandibular Disorders
Interventions: OTHER: Manual therapy|OTHER: Home physical therapy|OTHER: Manual therapy in cervical region|OTHER: Home physical therapy in cervical region
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of a Mobile Intervention to Increase Adherence to Asthma Medication Among Adolescents
Status: WITHDRAWN
Conditions: Asthma
Interventions: DEVICE: Inhaler sensor|BEHAVIORAL: Mobile application for asthma adherence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HCRN Endoscopic Versus Shunt Treatment of Hydrocephalus in Infants
Status: RECRUITING
Conditions: Hydrocephalus
Interventions: PROCEDURE: Endoscopic Third Ventriculostomy with Choroid Plexus Cauterization (ETV+CPC)|DEVICE: Ventriculoperitoneal Shunt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurofeedback Based on Near-infrared Spectroscopy as a Therapy for Food Addiction in Obese Subjects.
Status: RECRUITING
Conditions: Obesity|Craving
Interventions: OTHER: Sham|OTHER: NF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Lipid Regulating Effects of 1-Methylnicotinamide (1-MNA)
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DIETARY_SUPPLEMENT: 1-Methylnicotinamide (1-MNA)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Treatment of Breast Cancer With Two Different Sequential Treatment Regimens
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: pemetrexed|DRUG: cyclophosphamide|DRUG: doxorubicin|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on Safety and Efficacy of Anti-CLL1 /+CD33 CAR T Cells in the Treatment of Acute Myeloid Leukemia
Status: WITHDRAWN
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: CLL1/+CD33 CAR-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Periodontal Therapy in the Systemic Status of Individuals With Chronic Periodontitis and Diabetes Type 2
Status: TERMINATED
Conditions: Chronic Periodontitis|Diabetes Type 2
Interventions: DEVICE: Mechanical periodontal therapy|PROCEDURE: nonsurgical periodontal therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Presepsin to Safely Reduce Antibiotics in Preterm Infants
Status: RECRUITING
Conditions: Early-Onset Neonatal Sepsis
Interventions: DIAGNOSTIC_TEST: Presepsin|DIAGNOSTIC_TEST: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC