pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Steroids on Post-Operative Complications Following Proximal Hypospadias Repair
Status: TERMINATED
Conditions: Hypospadias
Interventions: DRUG: Prednisolone|DRUG: placebo-controlled
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Clinical Study to Compare Long-term Efficacy and Safety of an Aliskiren Based Regimen to a Hydrochlorothiazide Based Treatment Regimen With Optional Addition of Amlodipine
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Aliskiren
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Transdermal Ketoprofen to Treat Mild to Moderate Osteoarthritis (OA) Pain of the Knee
Status: COMPLETED
Conditions: Pain|Osteoarthritis, Knee
Interventions: DRUG: Transdermal Ketoprofen Patch with CHADD|DRUG: Placebo transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan Liposome II in Combination With 5-FU/LV and Oxaliplatin in Perioperative Treatment of Borderline Resectable Pancreatic Cancer
Status: RECRUITING
Conditions: Borderline Resectable Pancreatic Cancer
Interventions: DRUG: irinotecan liposome II combined with 5-FU/LV and oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetuximab in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Neoplasms|Neoplasm Metastasis|Liver Neoplasms
Interventions: DRUG: Cetuximab|DRUG: chemotherapy of mFOLFOX6 or FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Evaluation of Cesarean Scar After Uterotomy Closure With Barbed and Conventional Sutures
Status: UNKNOWN
Conditions: Cesarean Section Scar
Interventions: DEVICE: Cesarean section incision closure using barbed sutures|DEVICE: Cesarean section incision closure using conventional sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Characterize the Phenotype in Patients With Morton's Neuroma and to Explore the Effect of Local Administration of Xylocaine (Lidocaine)
Status: COMPLETED
Conditions: Morton's Neuroma
Interventions: DRUG: Xylocaine|DRUG: Xylocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reward Re-Training: A New Treatment to Address Reward Imbalance During the COVID-19 Pandemic
Status: COMPLETED
Conditions: Bulimia Nervosa|Bulimia; Atypical|Binge Eating|Binge-Eating Disorder
Interventions: BEHAVIORAL: Reward Re-Training|BEHAVIORAL: Supportive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Lisinopril and Warfarin in Healthy Subjects
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: semaglutide|DRUG: lisinopril|DRUG: warfarin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Positioning After Surgery for Macular Holes
Status: COMPLETED
Conditions: Macular Holes
Interventions: PROCEDURE: Vitrectomy & Intraocular gas fill|PROCEDURE: Postoperative face-down positioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of JS105 in Combination With Other Anti-tumor Therapies in Patients With Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: JS105|DRUG: Fulvestrant injection|DRUG: Dalpiciclib Isetionate Tablets|DRUG: Toripalimab Injection|DRUG: Paclitaxel for Injection (Albumin Bound)|DRUG: Fluzoparib Capsules|DRUG: Pyrotinib Maleate Tablets|DRUG: Capecitabine Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cryoballoon Isolation of Superior Vena Cava in Paroxysmal Atrial Fibrillation
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: superior vena cava isolation|DEVICE: pulmonary vein isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-Based Intervention for Caregivers of Frail Older Chinese Adults
Status: RECRUITING
Conditions: Frailty|Caregiver Burnout
Interventions: BEHAVIORAL: Brief mindfulness based program|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Autologous Tumor Infiltrating Lymphocytes in Patients With Pretreated Metastatic Triple Negative Breast Cancer
Status: COMPLETED
Conditions: Metastatic Triple Negative Breast Cancer
Interventions: DRUG: Tumor infiltrating lymphocytes (TIL) LN-145
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Types of Suture for Sacral Colpopexy
Status: COMPLETED
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: laparoscopic sacral colpopexy with absorbable suture|PROCEDURE: laparoscopic sacral colpopexy with non absorbable suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis
Status: NOT_YET_RECRUITING
Conditions: Septic Shock
Interventions: DRUG: Early Vasopressin|DRUG: Norepinephrine and Vasopressin for Rescue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identifying Efficient Linkage Strategies for Men
Status: ACTIVE_NOT_RECRUITING
Conditions: Hiv
Interventions: OTHER: Male Counseling and Facility Navigation|OTHER: Home-Based ART Initiation and Facility Navigation|OTHER: Stepped Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Etripamil Nasal Spray in Patients With Paroxysmal Supraventricular Tachycardia
Status: ENROLLING_BY_INVITATION
Conditions: Paroxysmal Supraventricular Tachycardia
Interventions: DRUG: Etripamil NS 70 mg|DEVICE: Aptar Pharma Nasal Spray Bidose System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy of Liraglutide in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Suture Ligation Versus Clipping of Cystic Duct and Artery During Laparoscopic Cholecystectomy
Status: UNKNOWN
Conditions: Laparoscopic Cholecystectomy
Interventions: PROCEDURE: clipping or ligation of the cystic duct and the cystic artery in Laparoscopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Trunk Stabilization Versus Activation Exercises on Pain and Disability in Postpartum Lumbo-pelvic Pain
Status: COMPLETED
Conditions: Pelvic Pain
Interventions: OTHER: Trunk stabilization|OTHER: Activation exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Wintertime Dose of Vitamin D3 to Prevent Winter Decline in Vitamin D Status in Healthy Adults
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: 250,000 IU cholecalciferol as single, oral dose|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of DE-108 Ophthalmic Solution in Patients Who Are Scheduled for Cataract Surgery
Status: COMPLETED
Conditions: Cataract Surgery
Interventions: DRUG: DE-108|DRUG: Levofloxacin 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Manual Therapy on Tibiotarsal Joint Mobility in Diabetic Individuals
Status: COMPLETED
Conditions: Diabetes Complications
Interventions: PROCEDURE: High Velocity Low Amplitude manipulation (HVLA)|PROCEDURE: Care assessment and guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Envollizumab Combined With Fruquintinib and SOX Versus SOX for Conversion Therapy in Advanced Gastric Cancer
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Envolimab|DRUG: Fruquintinib|DRUG: Oxaliplatin|DRUG: Tegafur
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Appropriate Opioid Quantities for Acute Pain - Pharmacist Study
Status: COMPLETED
Conditions: Opioid Use|Acute Pain
Interventions: DRUG: Pharmacist Practice Change to Dispense Appropriate Opioid Quantities for Acute Pain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Epidemiology and Acute Oral Effects Electronic Cigarette
Status: COMPLETED
Conditions: Nicotine Dependence, Cigarettes
Interventions: DEVICE: ProVari v2.5 (E-cigarette)|DEVICE: Marlboro Gold (Conventional cigarette)|DEVICE: Cigarette tip
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Glybera Registry, Lipoprotein Lipase Deficient (LPLD) Patients
Status: COMPLETED
Conditions: Lipoprotein Lipase Deficiency|Familial Hyperlipoproteinemia Type 1|Familial Hyperchylomicronemia
Interventions: OTHER: Observational study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Early Goal-Directed Therapy Utilizing Transpulmonary Thermodilution and Severe Burn Injury
Status: COMPLETED
Conditions: Burns
Interventions: OTHER: Control group: Patients being admitted when The advancement of transpulmonary thermodilution(TPTD) device was unavailable.|OTHER: Study group: TPTD device was implemented for monitoring.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CCFZ533X2201 - PoC Study in de Novo Renal Transplantation
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: BIOLOGICAL: CFZ533|DRUG: Tacrolimus (Tac)|DRUG: Mycophenolate mofetil (MMF)|DRUG: Corticosteroids (CS)|BIOLOGICAL: anti-IL2 Induction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial to Investigate the Dose-linearity of BioChaperone® Combo 75/25 and the Safety at Three Different Doses in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: BioChaperone® Combo 75/25 at 0.6 U/kg|DRUG: BioChaperone® Combo 75/25 at 0.8 U/kg|DRUG: BioChaperone® Combo 75/25 at 1.0 U/kg|DRUG: Humalog® Mix25 at 0.8 U/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis
Status: RECRUITING
Conditions: Leptomeningeal Metastasis|Leptomeningeal Disease|Leptomeningeal Neoplasms|Leptomeningeal Cancer
Interventions: OTHER: Neurological Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate Safety and Preliminary Efficacy of Tafasitamab With Idelalisib or Venetoclax in R/R CLL/SLL Patients Pretreated With BTKi
Status: COMPLETED
Conditions: Leukemia, Lymphocytic, Chronic, B-Cell|Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: BIOLOGICAL: Tafasitamab|DRUG: Idelalisib|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing a Dose-Response Relationship of Hydralazine and Its Effects on DNA Methyltransferase 1 in Polycystic Kidney Disease Patients
Status: COMPLETED
Conditions: Polycystic Kidney Diseases
Interventions: DRUG: Hydralazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PCR and Rapid Diagnostic Test on Saliva and Nasopharyngeal Swabs for the Detection of SARS-CoV-2 (COVID-19)
Status: UNKNOWN
Conditions: COVID-19|SARS-CoV-2
Interventions: DIAGNOSTIC_TEST: Rapid Diagnostic Test vs PCR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of High-concentration Topical Capsaicin on Histaminergic and Non-histaminergic Itch
Status: COMPLETED
Conditions: Pruritus
Interventions: DRUG: Capsaicin 24 Hours|DRUG: Capsaicin 1 Hour|OTHER: Qutenza Demo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Respiratory Drive and Inspiratory Effort in COVID-19 Associated ARDS
Status: COMPLETED
Conditions: ARDS, Human|COVID-19 Respiratory Infection|COVID-19 Acute Respiratory Distress Syndrome|Respiratory Effort-Related Arousal|Weaning Failure|Mechanical Ventilation Complication|Acute Hypoxic Respiratory Failure
Interventions: OTHER: Respiratory drive and effort assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Arzoxifene on Bone Fractures and Incidence of Breast Cancer
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal
Interventions: DRUG: Arzoxifene|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Administration of Pre-Operative Gabapentin to Patients Undergoing Laparoscopy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Gabapentin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Statins in Patients With Clonal Cytopenia of Undetermined Significance (CCUS) and Myelodysplastic Syndromes (MDS)
Status: RECRUITING
Conditions: Clonal Cytopenia of Undetermined Significance|Myelodysplastic Syndromes
Interventions: DRUG: Atorvastatin|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Impact of Routine Abdominal Drainage After Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Abdominal Drainage|Laparoscopic Cholecystectomy|Gall Stones
Interventions: PROCEDURE: intra abdominal drain|PROCEDURE: LC without drain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Comparison Study of PF708 and Forteo in Healthy Subjects
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Teriparatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topotecan Using Convection-Enhanced Delivery (CED) in High Grade Glioma
Status: COMPLETED
Conditions: Malignant Glioma|WHO Grade III or IV Recurrent Glioma
Interventions: DRUG: Topotecan|DRUG: Gadolinium DTPA|DEVICE: Cleveland Multiport Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicentric Prospective Clinical Study to Evaluate the Aktiia Optical Blood Pressure Monitoring (OBPM) Device Compared to Standard Home Blood Pressure Monitoring (HBPM) in Hypertensive Patients When Blood Pressure Lowering Medications Intake
Status: RECRUITING
Conditions: Hypertension
Interventions: OTHER: Aktiia Optical Blood Pressure Monitoring (OBPM) device and antihypertensive drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dietary Choice for the Management of Cow's Milk Allergy Influences Other Allergic Manifestations
Status: COMPLETED
Conditions: Allergy Milk|Allergy;Food|Allergic Asthma|Allergic Conjunctivitis|Allergy Skin
Interventions: DIETARY_SUPPLEMENT: hypoallergenic formulas
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cadonilimab(AK104) Plus Concurrent Chemoradiotherapy in Patients With Locally Advanced, Unresectable, Stage III NSCLC
Status: RECRUITING
Conditions: NSCLC|Locally Advanced Lung Carcinoma
Interventions: DRUG: Cadonilimab (AK104)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NNC 90-1170 Mechanism of Action: A Double-Blind, Randomized, Single-Center, Placebo-Controlled, Crossover Study to Examine Beta-Cell Responsiveness to Graded Glucose Infusion in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Non-Insulin-Dependent
Interventions: DRUG: NNC 90-1170
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine (GSK1437173A) in Adults ≥ 65 Years of Age With and Without Zostavax® Vaccination at Least 5 Years Earlier
Status: COMPLETED
Conditions: Herpes Zoster
Interventions: BIOLOGICAL: GSK Biologicals Herpes Zoster subunit (HZ/su) vaccine (GSK 1437173A)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Monotherapy Versus Bitherapy in Non-severe Hospitalized Community-acquired Pneumonia
Status: COMPLETED
Conditions: Community-acquired Pneumonia
Interventions: DRUG: Beta lactam (amoxicillin / clav. acid OR cefuroxime)|DRUG: Beta-lactam (amoxicillin / clav. acid OR cefuroxime) AND macrolide (clarithromycin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Functional Near Infra-Red Spectroscopic Study of Central Auditory System Cortical Functional Reorganization
Status: TERMINATED
Conditions: Hearing Loss, Unilateral
Interventions: DEVICE: fNIRS|OTHER: Speech intelligibility|OTHER: Sound localisation|OTHER: Speech assessments|OTHER: Quality of Life
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impact of Preoperative Bathing on Post Caesarean Section Surgical Site Infection
Status: COMPLETED
Conditions: Cesarean Wound Disruption With Postnatal Complication
Interventions: OTHER: preoperative bathing with antiseptic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Interpersonal Relationship Psychotherapy and Laughter Therapy
Status: COMPLETED
Conditions: Midwifery Students
Interventions: BEHAVIORAL: psychotherapy of interpersonal relationships|BEHAVIORAL: laughter therapy|BEHAVIORAL: Plasebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: An Open Label Study of Chronic Use of BLI400 Laxative in Constipated Adults
Status: COMPLETED
Conditions: Constipation|Chronic Idiopathic Constipation|CIC
Interventions: DRUG: BLI400 Laxative
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HPVPro Study: Comparison of HPV Detection in Clinician-collected Cervical Swabs and Self-sampled Cervicovaginal Swabs
Status: COMPLETED
Conditions: Cervical Cancer|Cervical Dysplasia|Human Papillomavirus Infection
Interventions: DIAGNOSTIC_TEST: Self-sampling using digene HC2 DNA Collection Device|DIAGNOSTIC_TEST: Self-sampling using Evalyn Brush
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Preoperative Stereoscopic Localization Versus Methylene Blue Localization in GGO Wedge Resection
Status: UNKNOWN
Conditions: Thoracic Surgery, Video-Assisted
Interventions: PROCEDURE: Preoperative Stereoscopic Localization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Digital Vaginal Examination During Labor on Pain and Anxiety Levels
Status: UNKNOWN
Conditions: Pregnancy|Obstetric Labor
Interventions: OTHER: Digital vaginal examination|DEVICE: Transperineal ultrasound examination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: GATA6 Expression as a Predictor of Response to Peri-Operative Chemotherapy in Resectable Pancreatic Adenocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Resectable Pancreatic Cancer
Interventions: DRUG: Modified Folforinox (mFFX)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile-based Social Services Screening and Referral Tool in an Pediatric Emergency Department
Status: COMPLETED
Conditions: Poverty|Social Determinants of Health|Mobile Applications|Pediatric ALL|Emergencies
Interventions: OTHER: HelpSteps application
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Immunogenicity Study of an Inactivated Influenza Vaccine (Whole Virion, Vero Cell Derived)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Inactivated influenza vaccine (whole virion, Vero cell-derived)|BIOLOGICAL: Inactivated influenza vaccine (egg derived) [licensed control vaccine]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: Investigating the Effect of Pericapsular Nerve Group (PENG) Block on Postoperative Pain After Peri-acetabular Osteotomy
Status: RECRUITING
Conditions: Anesthesia, Local
Interventions: DRUG: Ropivacaine 5mg/ml 20ml|DRUG: Saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Decision Support in the Management of Labour
Status: COMPLETED
Conditions: Fetal Intrauterine Distress First Noted During Labor and or Delivery in Liveborn Infant|Team Based on Their Existing Guidelines and the Woman Consents to Have EFM and EFM is|Possible
Interventions: DEVICE: INFANT software
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: BREAST CANCER AND EXERCISE
Status: COMPLETED
Conditions: Prevent Osteoporosis and Osteoporotic Fractures|Improve Quality of Life|Improve Weight Control, and Muscular and Cardiovascular Fitness|Help the Patients to Return to Working Life|Reduce the Risk of Breast Cancer Recurrence|Reduce All-cause Mortality in Patients With Primary Breast Cancer
Interventions: OTHER: supervised training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Vitamin K2 Supplementation on Arterial Stifness and Cardiovascular Events in PEritonial DIAlysis
Status: UNKNOWN
Conditions: Vitamin K Deficiency|End Stage Renal Disease|Peritoneal Dialysis|Arterial Stiffness|Cardiovascular Morbidity|Mortality
Interventions: DIETARY_SUPPLEMENT: MenaQ7 ®, Nattopharma, ASA, Hovik, Norway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Induction Chemotherapy for Olfactory Neuroblastoma (ESICON)
Status: RECRUITING
Conditions: Olfactory Neuroblastoma
Interventions: DRUG: Gemcitabine+Cisplatin(GP); Cyclophosphamide+Etoposide+Cisplatin(CEP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comprehensive Acupuncture for Depressive Disorder With Comorbid Psychogenic Pain
Status: UNKNOWN
Conditions: Depression; Psychoneurotic|Pain
Interventions: DEVICE: ta-VNS|OTHER: Electro-acupuncture|DRUG: Citalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Chloroquine (CQ) Alone Compared to Concomitant CQ and Primaquine for Plasmodium Vivax Infection
Status: COMPLETED
Conditions: Malaria, Vivax
Interventions: DRUG: Chloroquine|DRUG: Primaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Leiomyosarcoma, Liposarcomas and Synovial Sarcoma With Trabectedin
Status: WITHDRAWN
Conditions: Leiomyosarcoma|Liposarcoma|Synovial Sarcoma
Interventions: DRUG: Trabectedin discontinuation|DRUG: Trabectedin continuation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D, Cardiovascular Disease, and African Americans
Status: COMPLETED
Conditions: Vitamin D Deficiency|Type 2 Diabetes Mellitus|Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Calcium carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation and Correlation of Serum Fetuin-A Levels in Periodontal Health and Disease: A Clinico-biochemical Study
Status: COMPLETED
Conditions: Gingivitis and Periodontal Diseases
Interventions: PROCEDURE: Non surgical periodontal therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Dose Intensified Radiotherapy of Spinal Metastases by Hypofractionated Radiation and IGRT hfSRT Mediated Boost
Status: UNKNOWN
Conditions: Spinal Metastases
Interventions: RADIATION: hypofractionated 12x3 Gy + integrated boost 12x4 Gy|RADIATION: hypofractionated 10x3 Gy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Reduced Noise Levels and Cycled Light on Visual and Neural Development in Preterm Infants
Status: COMPLETED
Conditions: Preterm Infants
Interventions: BEHAVIORAL: Noise reduction and cycled light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study in Healthy Participants Evaluating the Absorption of a BMS-986205 Tablet Into the Bloodstream Compared to a Reference Tablet
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: BMS-986205 reference tablet|DRUG: BMS-986205 tablet with free base
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine in Transversus Abdominis Plane Block for Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Elective Laparoscopic Cholecystectomy
Interventions: DRUG: placebo|DRUG: bupivacaine|DRUG: bupivacaine-dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Efficacy of Telemedicine Neurology Assessments on a Mobile Stroke Unit
Status: RECRUITING
Conditions: Ischemic Stroke|Intracerebral Hemorrhage
Interventions: OTHER: Telemedicine Assessment by Remote Neurologist|OTHER: In-Person Assessment by an Onboard Neurologist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Characterization of Retinal Vascular Disease in Eyes With Mild to Moderate NPDR in Diabetes Type 2
Status: COMPLETED
Conditions: NPDR - Non Proliferative Diabetic Retinopathy
Interventions: DIAGNOSTIC_TEST: Laboratory tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase 2a Study of BAX69 and 5-FU/Leucovorin or Panitumumab Versus Standard of Care in Subjects With Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: BIOLOGICAL: BAX69 + infusional 5-FU/LV|BIOLOGICAL: BAX69 + panitumumab|BIOLOGICAL: BAX69 + 5-FU/LV|BIOLOGICAL: BAX69 + panitumumab|DRUG: Standard of Care|BIOLOGICAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of RC18 Administered Subcutaneously to Subjects With Systemic Lupus Erythematosus(SLE)
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: Placebo plus standard therapy|BIOLOGICAL: RC18 80 mg plus standard therapy|BIOLOGICAL: RC18 160 mg plus standard therapy|BIOLOGICAL: RC18 240 mg plus standard therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diuretic and Renal Effects of Vaprisol When Administered Along With Furosemide and Nesiritide Continuous Infusion
Status: WITHDRAWN
Conditions: Heart Failure
Interventions: DRUG: Conivaptan|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanistic Clinical Trial of Individualized tDCS for Hallucinations in Schizophrenia
Status: WITHDRAWN
Conditions: Schizophrenia and Related Disorders
Interventions: DEVICE: neuroConn DC-Stimulator MR|DEVICE: Soterix MxN HD-tES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CAR-T Cell Immunotherapy for GD2 Positive Glioma Patients
Status: WITHDRAWN
Conditions: Glioma of Brain|CAR-T Cell Immunotherapy
Interventions: BIOLOGICAL: GD2 CAR-T immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FIH Clinical Investigation of Graphene Electrodes for Brain Mapping
Status: NOT_YET_RECRUITING
Conditions: Brain Tumor|Glioma
Interventions: DEVICE: INBRAIN Graphene Cortical Interface
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study Evaluating The Safety, Tolerability, Pharmacokinetics, And Efficacy Of Venetoclax In Combination With Atezolizumab, Carboplatin, And Etoposide In Participants With Untreated Extensive-Stage Small Cell Lung Cancer (ES-SCLC).
Status: TERMINATED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Venetoclax|DRUG: Atezolizumab|DRUG: Carboplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) Plus Chemotherapy in Participants With Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-7902-015/E7080-G000-321/LEAP-015)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced/Metastatic Gastroesophageal Adenocarcinoma
Interventions: BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Lenvatinib|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Leucovorin (or Levoleucovorin)|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intracranial Rescue Stenting for Acute Ischemic Stroke, Predictors of Outcomes
Status: UNKNOWN
Conditions: Ischemic Stroke|Thromboembolic Stroke
Interventions: DEVICE: intracranial rescue stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bio Equivalence Study of Torrent Pharmaceutical Ltd's Rosuvastatin Calcium Tablets Under Fasting Condition.
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Torrent's Rosuvastatin Calcium Tablets 40 mg|DRUG: Crestor 40 mg Tablets of AstraZeneca LP, USA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Tele-exercise Training on Cardiorespiratory Fitness in Patients With Cardiometabolic Multimorbidity
Status: UNKNOWN
Conditions: Heart Diseases|Type 2 Diabetes|Metabolic Syndrome|Coronary Artery Disease|Heart Failure
Interventions: BEHAVIORAL: tele-exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Order and Conjugation of Different Photobiomodulation Therapies and Anterior Repositioning Appliance in Management of TMD Cases
Status: COMPLETED
Conditions: TMJ Disorder
Interventions: DEVICE: Photobiomodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Selective Prevention of Anxiety Disorders in Children: A Parent Training Intervention for Anxious Parents
Status: COMPLETED
Conditions: Anxiety Disorders
Interventions: BEHAVIORAL: Group parent training for anxious parents|BEHAVIORAL: Internet delivered parent training for anxious parents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ESBA105 in Patients With Severe Dry Eye
Status: COMPLETED
Conditions: Eyes Dry Chronic
Interventions: BIOLOGICAL: ESBA105 ophthalmic solution|OTHER: ESBA105 vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Customized Foot Orthoses on Muscle Activity During Standing and Gait in Plantar Heel Pain
Status: NOT_YET_RECRUITING
Conditions: Foot Orthoses|Fasciitis, Plantar
Interventions: DEVICE: orthotic wedge|DEVICE: CFO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of 2 Fixed Dose Combinations of Empagliflozin/Linagliptin/Metformin Extended Release Compared With Single Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: High dose FDC Empagliflozin/Linagliptin/Metformin XR, fed|DRUG: 1 tab Empagliflozin +1 tab Linagliptin +2 tabs Metformin XR|DRUG: High dose FDC Empagliflozin/Linagliptin/Metformin XR, fasted|DRUG: 1 tab Empagliflozin +1 tab Linagliptin +2 tabs Metformin XR|DRUG: Low dose FDC Empagliflozin/Linagliptin/Metformin XR, fed|DRUG: 1 tab Empagliflozin +1 tab Linagliptin +2 tabs Metformin XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of High vs. Low Fluid Volume on Ocular Parameters in Prone Spine Surgery
Status: COMPLETED
Conditions: Prone Position|Blood Volume|Intraocular Pressure
Interventions: OTHER: Ringer's Lactate solution|PROCEDURE: Spine surgery under general Anesthesia in the prone position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of KAN-101 in Celiac Disease (ACeD-it)
Status: RECRUITING
Conditions: Celiac Disease
Interventions: DRUG: Cohort 1 in Part A|DRUG: Cohort 2 in Part A|OTHER: Placebo: Group 1 in Part B and Part C|DRUG: Group 2 in Part B and Part C|DRUG: Group 3 in Part B and Part C|DRUG: Group 4 in Part B and Part C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Safety of Dexlansoprazole in Adolescents With Gastroesophageal Reflux Disease
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: Dexlansoprazole MR|DRUG: Dexlansoprazole MR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Infusion Chemotherapy (CI-CLAM) for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Other High-Grade Myeloid Neoplasms
Status: TERMINATED
Conditions: Myeloid Neoplasm|Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Cladribine|DRUG: Cytarabine|BIOLOGICAL: Recombinant Granulocyte Colony-Stimulating Factor|DRUG: Mitoxantrone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamics Assessment Study After Single Subcutaneous Dose Of SAR113244 Versus Placebo In Lupus Male And Female Patients
Status: WITHDRAWN
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: SAR113244|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Chemotherapy and Radiation Therapy in Treating Children With Previously Untreated Stage II, Stage III, or Stage IV Hodgkin's Disease
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: bleomycin sulfate|BIOLOGICAL: filgrastim|DRUG: ABVD regimen|DRUG: cyclophosphamide|DRUG: dacarbazine|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: prednisone|DRUG: procarbazine hydrochloride|DRUG: vinblastine sulfate|DRUG: vincristine sulfate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measurement of Critical Closing Pressure (Pcrit) During Drug-Induced Sleep Endoscopy (DISE)
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DIAGNOSTIC_TEST: Drug induced sleep endoscopy|DIAGNOSTIC_TEST: Measurement of critical closing pressure of the uppper airway
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Virtual Reality Therapy and Cognitive Behavior Therapy in Panic Disorder With Agoraphobia
Status: UNKNOWN
Conditions: Panic Disorder|Agoraphobia
Interventions: BEHAVIORAL: Virtual Reality Therapy|BEHAVIORAL: Cognitive Behavior Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: ECT
Clinical trial: A Study of Andrographolide Sulfonate in Patients With Acute Exacerbation of Chronic Bronchitis
Status: UNKNOWN
Conditions: Acute Exacerbation of Chronic Bronchitis
Interventions: DRUG: andrographolide sulfonate|DRUG: andrographolide sulfonate simulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Safety and Tolerability of Lagricel® Ofteno Multi-dose Ophthalmic Solution
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: lagricel ofteno multidose|DRUG: lagricel ofteno single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Mechanical Decompression for Low Back Pain Relief
Status: WITHDRAWN
Conditions: Low Back Pain
Interventions: DEVICE: SpineMed Table, Cert HealthSciences LLC|DEVICE: SpineMed Table, Cert HealthSciences LLC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Novel Form of Nutritional Supplementation in Cancer Patients
Status: UNKNOWN
Conditions: Cancer|Malnutrition|Cachexia
Interventions: DIETARY_SUPPLEMENT: sip feed|DIETARY_SUPPLEMENT: gumdrops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Open-Label Study of a Novel JAK-inhibitor, INCB052793, Given to Patients With Advanced Malignancies
Status: TERMINATED
Conditions: Solid Tumors|Advanced Malignancies|Metastatic Cancer
Interventions: DRUG: INCB052793|DRUG: gemcitabine|DRUG: nab-paclitaxel|DRUG: dexamethasone|DRUG: Carfilzomib|DRUG: bortezomib|DRUG: lenalidomide|DRUG: azacitidine|DRUG: INCB052793|DRUG: pomalidomide|DRUG: INCB050465|DRUG: INCB039110
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccination of Patients With Ovarian Cancer With Dendritic Cell/Tumor Fusions With Granulocyte Macrophage Colony-stimulating Factor (GM-CSF) and Imiquimod
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer|Primary Peritoneal Cancer|Fallopian Tube Cancer
Interventions: DRUG: GM-CSF|BIOLOGICAL: Dendritic Cell/Tumor Fusion Vaccine|DRUG: imiquimod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Habituation of the Nociceptive Blink Reflex in Experimentally Induced Migraine Attack
Status: RECRUITING
Conditions: Migraine|Migraine Disorders|Pain
Interventions: DRUG: Nitroglycerin|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hospital-based Validation of the New ELEVATE Screening Tool in Belgium and Ecuador
Status: NOT_YET_RECRUITING
Conditions: Cervical Cancer|HPV Infection
Interventions: BEHAVIORAL: Questionnaire|PROCEDURE: HPV self-sample|PROCEDURE: Endocervical sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pedometer-Based Walking Intervention in Patients With Chronic Heart Failure With Reduced Ejection Fraction
Status: ACTIVE_NOT_RECRUITING
Conditions: Systolic Heart Failure
Interventions: BEHAVIORAL: Walking intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Protonix Treatment of Maintenance of Healing in Pediatric Participants Aged 1-11 Years and 12-17 Years
Status: RECRUITING
Conditions: Esophagitis
Interventions: DRUG: Full dose Pantoprazole plus matching placebo|DRUG: Half Dose Pantoprazole plus matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Atalante Exoskeleton on Gait Recovery in Non- or Poorly Ambulatory Patients With Hemiparesis in the Acute/Subacute Phase (Month 1 to 4)
Status: RECRUITING
Conditions: Stroke, Acute|Stroke, Ischemic|Stroke, Subacute|Stroke Hemorrhagic|Cerebrovascular Disorders|Cerebrovascular Accident|Hemiparesis|Hemiparesis;Poststroke/CVA|Hemiparesis/Hemiplegia (One Sided Weakness/Paralysis)
Interventions: DEVICE: Use of the Atalante exoskeleton
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanism and Dosimetry Exploration in TES Magnetic Resonance Current Mapping Methods
Status: COMPLETED
Conditions: Transcranial Direct Current Stimulation
Interventions: DEVICE: tDCS|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: CD19+Targeted CAR-T Cell Therapy for Relapsed/Refractory CD19+ B Cell Leukemia and Lymphoma
Status: RECRUITING
Conditions: Leukemia|Lymphoma, Large B-Cell, Diffuse|Leukemia, B-cell|Lymphoma, B-Cell|Leukemia, Lymphocytic, Chronic, B-Cell
Interventions: BIOLOGICAL: CD19 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Effectiveness of a Real-time Heart Team Approach in Complex CAD
Status: NOT_YET_RECRUITING
Conditions: Cardiovascular Diseases|Coronary Artery Disease|Multidisciplinary Communication
Interventions: BEHAVIORAL: heart team meeting and discussion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER