pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Chidamide + Regorafenib in Hepatocellular Carcinoma (HCC)
Status: RECRUITING
Conditions: Hepatocellular Carcinoma (HCC)
Interventions: DRUG: Chidamide|DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture Technique for Restoring Consciousness on Post-stroke Dysphagia
Status: NOT_YET_RECRUITING
Conditions: Dysphagia
Interventions: BEHAVIORAL: Routine rehabilitation training|PROCEDURE: Acupuncture Technique for Restoring Consciousness combined with Scalp Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy in Treating Children With Newly Diagnosed Malignant Germ Cell Tumors
Status: COMPLETED
Conditions: Childhood Germ Cell Tumor|Extragonadal Germ Cell Tumor
Interventions: BIOLOGICAL: bleomycin sulfate|BIOLOGICAL: filgrastim|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: etoposide|PROCEDURE: conventional surgery|BIOLOGICAL: MESNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Manufacturing, Characterization and Evaluation of the Effect of Silk Fibroin Membranes, Loaded or Not With Neurotensins on Open Wounds in the Palate
Status: UNKNOWN
Conditions: Wound Healing|Palate; Wound
Interventions: PROCEDURE: Palatal Wound|DEVICE: Palatal Wound treated with Silk Fibroin Film|DEVICE: Palatal Wound treated with Neurotensin-loaded Silk Fibroin Film
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sequential and Concurrent FOLFOXIRI/Bevacizumab Regimens Versus FOLFOX/Bevacizumab in First-Line Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Neoplasms
Interventions: DRUG: 5-fluorouracil|DRUG: bevacizumab|DRUG: capecitabine|DRUG: irinotecan|DRUG: folinic acid|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-859/KEYNOTE-859)-China Extension
Status: WITHDRAWN
Conditions: Stomach Neoplasms
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Cisplatin|DRUG: 5-fluorouracil|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Placebo for Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Post-Operative Pain Management of Pediatric Supracondylar Elbow Fractures
Status: COMPLETED
Conditions: Elbow Fracture
Interventions: DRUG: Oxycodone with Acetaminophen|DRUG: Bupivacaine 0.25%|DRUG: Ropivacaine 0.20%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Quadratus Lumborum Block for Pediatric Hip Surgery
Status: COMPLETED
Conditions: Hip Dislocation, Congenital|Postoperative Pain|Anesthesia
Interventions: PROCEDURE: anterior Quadratus lumborum block|PROCEDURE: caudal block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bloody or Well Done. How Would You Like Your Liver Biopsy, Sir?
Status: RECRUITING
Conditions: Liver Disease Parenchymal
Interventions: PROCEDURE: Group one - percutaneous (P)|PROCEDURE: Group two - EUS FNB (E)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparing Perioperative Outcomes in Pain Control
Status: ACTIVE_NOT_RECRUITING
Conditions: Post-operative Pain
Interventions: DRUG: Multimodal Pain Management (Ibuprofen/Acetaminophen/GABAPentin/0.25%Bupivacaine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of EBV-specific Cytotoxic T Cells for the Treatment for EBV Lymphomas or Other EBV-associated Malignancies
Status: WITHDRAWN
Conditions: EBV Lymphomas|EBV-associated Malignancies
Interventions: BIOLOGICAL: EBV-specific T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LMN-201 for Prevention of C. Difficile Infection Recurrence
Status: NOT_YET_RECRUITING
Conditions: Clostridioides Difficile Infection
Interventions: DRUG: LMN-201|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase I Safety, PK and PD Study of KW-2478 in Patients With Multiple Myeloma, Chronic Lymphocytic Leukaemia or B-cell Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Multiple Myeloma|Chronic Lymphocytic Leukaemia|B-cell Non-Hodgkin's Lymphoma
Interventions: DRUG: KW-2478
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Engaging Self-regulation Targets to Improve Mood and Weight and Understand Mechanism in Depressed and Obese Adults
Status: COMPLETED
Conditions: Obesity|Depression
Interventions: BEHAVIORAL: I-CARE2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RCT Determining Best Treatment for Geriatric Acetabular Fractures
Status: COMPLETED
Conditions: Acetabular Fracture
Interventions: PROCEDURE: Open Reduction internal Fixation|PROCEDURE: Open Reduction Internal Fixation with Total Hip Arthroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: STI.VI. Study: How to Improve Lifestyles in Screening Contexts
Status: COMPLETED
Conditions: Lifestyle Risk Reduction|Weight Changes, Body|Breast Cancer|Colorectal Cancer
Interventions: BEHAVIORAL: Diet group|BEHAVIORAL: Physical activity group|BEHAVIORAL: Physical activity and diet group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of the Consumption of a Fermented Milk Enriched With Plant Sterols (Italy)
Status: COMPLETED
Conditions: Mildly Hypercholesterolemic Subjects
Interventions: OTHER: 1- plain low-fat dairy fermented product (drinkable) enriched with plant sterols-esters (1,6g /day equivalent as free sterols).|OTHER: 2- plain low-fat dairy fermented product (drinkable) without plant sterols-esters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer (CHIPPI)
Status: RECRUITING
Conditions: Ovary Neoplasms|Ovarian Cancer|Ovarian Carcinoma
Interventions: DRUG: HIPEC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Vitamin D Supplementation in People With Crohn's Disease Improve Symptoms as an Adjunct Therapy?
Status: UNKNOWN
Conditions: Crohn Disease|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: fNIRS-based Neurofeedback Intervention for Cognitive Control Improvement in Emotional Overeating
Status: RECRUITING
Conditions: Hyperphagia
Interventions: DEVICE: Neurofeedback with functional near infra-red spectroscopy|DEVICE: Sham Neurofeedback|OTHER: oral microbiota collection|OTHER: Questionnaires|DEVICE: resting-state fMRI|DEVICE: Electro gastrogram|BEHAVIORAL: Emotional Stroop task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Use of Fibrin Sealant to Reduce Bleeding After Total Knee Replacement
Status: COMPLETED
Conditions: Total Knee Replacement|Primary Knee Arthroplasty|Osteoarthritis of the Knee
Interventions: DRUG: Evicel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ovarian Reserve and Matrix Metalloproteinases
Status: COMPLETED
Conditions: Oxidative Stress|Ovarian Insufficiency, Primary|Ovarian Failure, Premature
Interventions: DIAGNOSTIC_TEST: Prolidase Level|DIAGNOSTIC_TEST: Follicle Stimulating Hormone Level|DIAGNOSTIC_TEST: Estradiol Level|DIAGNOSTIC_TEST: Proline Level|DIAGNOSTIC_TEST: Hydroxyproline Level|DIAGNOSTIC_TEST: Anti-mullerian Hormone Level|DIAGNOSTIC_TEST: Antral Follicle Count|DIAGNOSTIC_TEST: Prolactine Level|DIAGNOSTIC_TEST: Thyroid Stimulating Hormone Level
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Systemic Corticosteroids in Treatment of Post-COVID-19 Interstitial Lung Disease
Status: COMPLETED
Conditions: Covid19|COVID-19 Pneumonia|Interstitial Lung Disease
Interventions: DRUG: Methylprednisolone Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Total Flavonoids of Propolis Dropping Pill to Treat Angina Pectoris
Status: COMPLETED
Conditions: Stable Angina Pectoris
Interventions: DRUG: Total Flavonoids of Propolis dropping pill|DRUG: total Flavonoids of Propolis dropping pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Vestibular Stimulation on Fat Consumption and Energy Expenditure as Assessed Using Indirect Calorimetry
Status: COMPLETED
Conditions: Obesity|Metabolic Syndrome
Interventions: DEVICE: Vestibular Nerve Stimulator|DEVICE: Sham stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility, Appropriateness, Meaningfulness and Effectiveness of Bedside Shift Reporting
Status: COMPLETED
Conditions: Nursing|Bedside Shift Report|Patient Participation
Interventions: BEHAVIORAL: Bedside shift report
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neurodevelopmental Outcome After Fetal Neonatal AlloImmune Thrombocytopenia
Status: UNKNOWN
Conditions: Fetal and Neonatal Alloimmune Thrombocytopenia|Long Term Adverse Effects|Neurodevelopmental Abnormality|Intravenous Immunoglobulin Adverse Reaction
Interventions: DIAGNOSTIC_TEST: Cognitive testing (Bayley III, WPPSI III and WISC V)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Observational Study of Rebismart®2.0 + MSdialog™ in Subjects With Remitting Multiple Sclerosis (ADHERQOL)
Status: TERMINATED
Conditions: Multiple Sclerosis, Relapsing-remitting
Interventions: DEVICE: RebiSmart®2.0|DEVICE: MSdialog™
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Does Perineural Dexamethasone Increase the Duration of an Ulnar Nerve Block When Controlling for Systemic Effects?
Status: COMPLETED
Conditions: Anesthesia, Local
Interventions: DRUG: Perineural dexamethasone|DRUG: Lidocaine|DRUG: Placebo|DRUG: Systemic dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Osimertinib Resistance in Patients With Non-small-cell Lung Carcinoma That Have Progressed.
Status: RECRUITING
Conditions: Non-small-cell Lung Carcinoma
Interventions: DIAGNOSTIC_TEST: biopsy|DIAGNOSTIC_TEST: ctDAN analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Antibiotic Prophylaxis to Prevent Post-procedure UTI After VCUG
Status: NOT_YET_RECRUITING
Conditions: Antibiotic Prophylaxis|Voiding Cystourethrogram|Febrile Urinary Tract Infection
Interventions: DRUG: Antibiotic Prophylaxis|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Laughter Therapy Effects on Mood, Stress and Self-efficacy in People With Neurological Diseases.
Status: COMPLETED
Conditions: Alzheimer's Disease|Amyotrophic Lateral Sclerosis|Brain Injury|Huntington's Disease|Multiple Sclerosis|Parkinson's Disease|Stroke|Spinal Cord Injury
Interventions: OTHER: Laughter Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: OUTpatient Treatment of COVID-19 in Patients With Risk Factor for Poor Outcome
Status: WITHDRAWN
Conditions: COVID
Interventions: DRUG: Azithromycin|DRUG: Hydroxychloroquine|DRUG: Lopinavir 200Mg/Ritonavir 50Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Exploratory Study to Investigate the Effect of Ramelteon for Insomnia Patients With Major Depressive Disorder by Using Actigraphy
Status: COMPLETED
Conditions: Insomnia|Major Depressive Disorder
Interventions: DRUG: Ramelteon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study Evaluating the Safety of Proellex® in Premenopausal Women With Uterine Fibroids
Status: TERMINATED
Conditions: Uterine Fibroids
Interventions: DRUG: Proellex 25 mg|DRUG: Proellex 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changing the Default for Tobacco Treatment
Status: COMPLETED
Conditions: Tobacco Use Cessation
Interventions: BEHAVIORAL: Opt Out Treatment Program|DRUG: Nicotine Replacement Therapy|BEHAVIORAL: Opt In Treatment Program|DRUG: Nicotine Replacement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Thiotepa, Cyclophosphamide, Clarithromycin and Cytarabine
Status: RECRUITING
Conditions: Burkitt Lymphoma|Lymphoblastic Lymphoma, Adult|Acute Lymphoblastic Leukemia, Adult
Interventions: DRUG: Thiotepa, cyclophosphamide, cladribine, and cytarabine conditioning regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact Of Soft Tissue Manipulation On Dimensional Changes After Posterior Region Extraction.
Status: UNKNOWN
Conditions: Alveolar Ridge Preservation|Connective Tissue
Interventions: PROCEDURE: Alveolar Ridge Preservation With Gingival Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Impact of a mHealth Application on Outpatient Physical Therapy HEP Adherence and Outcomes: A RCT
Status: COMPLETED
Conditions: Orthopedic Disorder|Musculoskeletal Injury
Interventions: OTHER: Augmented Media Group|OTHER: Traditional Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Compare the Effects of Non-nutritive Sweeteners Intake in Subjects With T2DM
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Intervention ingest a 48 mg of sucralose|OTHER: Intervention ingest a 96 mg of stevia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Erector Spinae Plane Block Versus Quadratus Lumborum Block for Postoperative Analgesia in Children
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Erector Spinae Plane Block|PROCEDURE: Quadratus Lumborum Block|DRUG: Bupivacaine (Block Drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment Result of Zirconia Laminate Veneer
Status: RECRUITING
Conditions: Dislocation, Tooth|Teeth, Endodontically-Treated|Tooth Fracture|Tooth Injuries|Tooth Abnormalities|Cracked Tooth Syndrome|Tooth Crowding
Interventions: DEVICE: Zirconia laminate veneer|DEVICE: Lithium Disilicate laminate veneer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Budesonide on Exhaled Nitric Oxide in Asthmatic Children
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Nebulized Budesonide|DEVICE: Nitric Oxide Analyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Interventions to Improve Warfarin Adherence
Status: COMPLETED
Conditions: Atrial Fibrillation|Deep Vein Thrombosis|Dilated Cardiomyopathies
Interventions: BEHAVIORAL: Financial Incentive and Med-eMonitor|DEVICE: 2Med-eMonitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Psychological Impact of Amenorrhea in Women With Endometriosis
Status: UNKNOWN
Conditions: Amenorrhea|Endometriosis|Quality of Life
Interventions: DRUG: Estroprogestinic therapy (Etinil-estradiol/levonorgestre)|DRUG: Gonadotropin-releasing hormone agonist (Leuprorelin acetate)|DRUG: Add back therapy 1 (tibolone)|DRUG: Add back therapy 2 (calcium carbonate/colecalciferol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of a Candidate Tuberculosis (TB) Vaccine Given to Healthy Adults in a TB-endemic Region
Status: COMPLETED
Conditions: Tuberculosis (TB)|Tuberculosis Vaccines
Interventions: BIOLOGICAL: GSK Biologicals' Candidate Tuberculosis (TB) Vaccine (692342)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intergroup Trial of Adjuvant Chemotherapy in Adenocarcinoma of the Stomach
Status: COMPLETED
Conditions: Adenocarcinoma of the Stomach|Adenocarcinoma of the Gastroesophageal Junction
Interventions: DRUG: Irinotecan, Leucovorin, 5-Fluorouracil, Docetaxel, Cisplatin|DRUG: Leucovorin, 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single and Multiple Ascending Doses of AZD1981 in Japan
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD1981|DRUG: AZD1981|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Infraclavicular Perineural Dexmedetomidine
Status: COMPLETED
Conditions: The Analgesic Effects
Interventions: DRUG: Bupivacaine|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Vedolizumab Treatment to Adalimumab Dose Intensification in Crohn's Disease Patients With Loss of Response or Biomarker Activity to Adalimumab on First Line With Therapeutic Drug Concentration.
Status: NOT_YET_RECRUITING
Conditions: Crohn's Disease
Interventions: DRUG: Adalimumab|DRUG: Vedolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effect of Nicotine Reduction on ENDS User's Addiction and Exposures
Status: RECRUITING
Conditions: Electronic Cigarette Use
Interventions: OTHER: 5% nicotine|OTHER: 3% nicotine|OTHER: 0% nicotine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Quick Start Durvalumab Following Chemoradiation for Stage III Nonsmall Cell Lung Cancer
Status: RECRUITING
Conditions: Nonsmall Cell Lung Cancer Stage III|Unresectable Non-Small Cell Lung Carcinoma
Interventions: DRUG: Durvalumab|OTHER: the EORTC Core Quality of Life Questionnaire (EORTC QLQ-C30)|DIAGNOSTIC_TEST: COPD Assessment Test (CAT)|DIAGNOSTIC_TEST: Modified Medical Research Council (mMRC) dyspnea scale
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise Training to Improve PTSD Symptoms and Health in Older Veterans
Status: RECRUITING
Conditions: Post-traumatic Stress Disorder
Interventions: BEHAVIORAL: Exercise Training|OTHER: Healthy Aging Attention Control (HA-ATC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Manual Lymphatic Drainage in Chronic Venous Insufficiency: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Chronic Venous Insufficiency
Interventions: OTHER: Manual Lymphatic Drainage|BEHAVIORAL: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Post-operative Complication, Impulsive Compression, in Situ Bypass
Status: UNKNOWN
Conditions: Compresion Therapy|Post-operative Edema|Wound Complication|Ischemia Limb|Quality of Life
Interventions: DEVICE: A-V impulse 6000 Series|DEVICE: Standard treatment (compression)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Listening to Music Alter the Running Mechanics?
Status: RECRUITING
Conditions: Healthy
Interventions: OTHER: Running while listening to a traffic audio track|OTHER: Running with music at moderate volume|OTHER: Running with music at moderate-to-high volume
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Can we Use c-SIGHT for Spatial Neglect in Stroke Survivors' Homes?
Status: UNKNOWN
Conditions: Stroke|Spatial Neglect|Inattention
Interventions: BEHAVIORAL: c-SIGHT intervention|BEHAVIORAL: c-SIGHT attentional control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study in Diabetes Mellitus(Fasting)
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus
Interventions: DRUG: HUC2-344|DRUG: HUC2-344-R1, HUC2-344-R2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Muscle Training and Low Back Pain
Status: COMPLETED
Conditions: Inspiratory Muscle Training|Low Back Pain|Respiratory Disorders
Interventions: OTHER: Inspiratory muscle training|OTHER: Sham inspiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypoallergenic Infant Formula Containing Starch and the Probiotic: Effect on Gastric Emptying
Status: COMPLETED
Conditions: Regurgitation, Gastric
Interventions: DIETARY_SUPPLEMENT: HA formula + starch + L. reuteri
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine and Ketamine as an Adjuvant in External Oblique Intercostal Plane Block for Post Thoracotomy Pain
Status: RECRUITING
Conditions: Dexmedetomidine|Ketamine|External Oblique Intercostal Plane Block|Post Thoracotomy Pain
Interventions: DRUG: Ketamine|DRUG: Dexmedetomidine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Digital Health Integration With Pulmonary Rehabilitation on Patients With Chronic Obstructive Lung Disease
Status: RECRUITING
Conditions: Chronic Obstructive Lung Disease
Interventions: OTHER: pulmonary rehabilitation|OTHER: pursed lip breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Single-Group Study to Examine the Efficacy of a Gut Health Supplement to Increase Metabolism, Improve Gut Health, and Support Weight Management
Status: ACTIVE_NOT_RECRUITING
Conditions: Gut Health|Metabolism|Weight Loss|Energy
Interventions: DIETARY_SUPPLEMENT: Colon Broom Premium supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Intranasal Dexmedetomidine Versus Intranasal Midazolam as a Premedication in Pediatrics Undergoing Upper GI Endoscopy
Status: NOT_YET_RECRUITING
Conditions: Anesthesia
Interventions: DRUG: Dexmedetomidine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Tart Cherry Juice to Reduce Pain and Inflammation Among Patients With Inflammatory Osteoarthritis
Status: COMPLETED
Conditions: Pain|Inflammation
Interventions: DIETARY_SUPPLEMENT: tart cultivar Montmorency cherry juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Itacitinib (INCB039110) and Extracorporeal Photopheresis (ECP) for First-Line Treatment in Chronic GVHD
Status: TERMINATED
Conditions: Chronic Graft-versus-host-disease
Interventions: DRUG: Itacitinib|DEVICE: Extracorporeal Photopheresis (ECP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Older Patients With Refractory or Relapsed Intermediate-Grade Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: carmustine|DRUG: cytarabine|DRUG: etoposide|DRUG: ifosfamide|DRUG: melphalan|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Clinical and Biological Characterization of Post COVID-19 Syndrome
Status: RECRUITING
Conditions: Long COVID
Interventions: DIAGNOSTIC_TEST: Clinical, mental health and psychosocial profile of Post-COVID-19 syndrome|DIAGNOSTIC_TEST: Diagnostic performance of echocardiographic and biological markers in Post-COVID-19 syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Attention to Variability During Infertility
Status: UNKNOWN
Conditions: Infertility|Infertility, Female|Infertility, Male
Interventions: BEHAVIORAL: Attention to Variability - Patient Only|BEHAVIORAL: Attention to Variability - Partner Only|BEHAVIORAL: Attention to Variability - Patient & Partner|OTHER: Infertility Stories - Reading
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Xepol (Human Immunoglobulin) in Subjects With Post-Polio Syndrome (PPS)
Status: COMPLETED
Conditions: Post Polio Syndrome, PPS
Interventions: DRUG: Xepol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Pediatric Burn Treatment Using Tilapia Skin as a Xenograft for Superficial-Partial Thickness Wounds
Status: COMPLETED
Conditions: Burns
Interventions: OTHER: Tilapia skin|DRUG: silver sulfadiazine cream 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Levcromakalim in Patients With Cluster Headache
Status: COMPLETED
Conditions: Cluster Headache
Interventions: DRUG: Levcromakalim|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Multiple Ascending Dose Study of Milademetan in Subjects With Advanced Solid Tumors or Lymphomas
Status: COMPLETED
Conditions: Advanced Solid Tumor|Lymphoma
Interventions: DRUG: Milademetan|DRUG: Milademetan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trebananib And Temsirolimus in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Adult Solid Neoplasm|Lung Carcinoid Tumor|Recurrent Digestive System Neuroendocrine Tumor G1|Recurrent Renal Cell Carcinoma|Recurrent Uterine Corpus Sarcoma|Stage III Renal Cell Cancer|Stage IIIB Uterine Sarcoma|Stage IIIC Uterine Sarcoma|Stage IV Renal Cell Cancer|Stage IVA Uterine Sarcoma|Stage IVB Uterine Sarcoma
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Temsirolimus|BIOLOGICAL: Trebananib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Efficacy of AntiBKV as Treatment of BKV Infection in Kidney Transplant Recipients
Status: RECRUITING
Conditions: BK Viremia; BKV DNAemia
Interventions: BIOLOGICAL: Anti-BK polyomavirus (AntiBKV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bone Metabolism Adjacent to Hip Prosthetic Surfaces. A Clinical F-PET/CT Study
Status: UNKNOWN
Conditions: Hip Osteo Arthritis
Interventions: DEVICE: Surgery for Total Hip Arthroplasty (THA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Endoscopic Ultrasound-Guided Radiofrequency Ablation for the Management of Pancreatic Tumors, ERASE Study
Status: RECRUITING
Conditions: Pancreatic Neoplasm
Interventions: PROCEDURE: Chemical Ablation|PROCEDURE: Computed Tomography|OTHER: Electronic Health Record Review|PROCEDURE: Endoscopic Ultrasound-Guided Fine-Needle Aspiration|PROCEDURE: Endoscopic Ultrasound-Guided Radiofrequency Ablation|PROCEDURE: Magnetic Resonance Cholangiopancreatography|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Maintenance ECT Versus Clozapine in Treatment-resistant Schizophrenia
Status: COMPLETED
Conditions: Treatment Resistant Schizophrenia
Interventions: OTHER: Bilateral M-ECT|DRUG: Clozapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-MUC1 CAR T Cells and PD-1 Knockout Engineered T Cells for NSCLC
Status: UNKNOWN
Conditions: Lung Neoplasm Malignant|Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: CAR-T Cells|COMBINATION_PRODUCT: CAR-T combining PD-1 Knockout|BIOLOGICAL: PD-1 knockout|DRUG: PD-1 mAb|OTHER: Sham control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sintilimab Combined With Docetaxel for Standard Chemotherapy Failure Non-driver Gene Mutation Metastatic Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Sintilimab Combined With Docetaxel Monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Secukinumab Compared to Ustekinumab in Patients With Plaque-type Psoriasis
Status: COMPLETED
Conditions: Chronic Plaque Type Psoriasis
Interventions: DRUG: AIN457 300 mg|DRUG: ustekinumab 45/90 mg|DRUG: placebo secukinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Transcranial Direct Current Stimulation on the Capacity to Perform Burpees
Status: COMPLETED
Conditions: Transcranial Direct Current Stimulation|Dorsolateral Prefrontal Cortex|Primary Motor Cortex
Interventions: DEVICE: tDCS targeting DLPFC|DEVICE: tDCS targeting M1|DEVICE: SHAM tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy
Status: RECRUITING
Conditions: Radiation Retinopathy|Visual Impairment
Interventions: DRUG: Faricimab|DRUG: fluocinolone acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Hydroxyethylstarch 6% 130/0.4 in a Balanced Electrolyte Solution (Volulyte®) Compared to Gelatine (Geloplasma®) on Microvascular Reactivity and Tissue Oxygen Saturation During Haemodilution Measured With Near-infrared Spectroscopy
Status: COMPLETED
Conditions: Microvascular Reactivity|Tissue Oxygen Saturation
Interventions: DRUG: Volulyte 6%|DRUG: Geloplasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interferon Alfa With or Without Combination Chemotherapy Plus Interleukin-2 in Treating Patients With Melanoma
Status: COMPLETED
Conditions: Melanoma|Skin Cancer
Interventions: BIOLOGICAL: Aldesleukin (IL-2)|BIOLOGICAL: Recombinant Interferon Alfa (IFN-A)|DRUG: Cisplatin|DRUG: Dacarbazine|DRUG: Vinblastine|PROCEDURE: Adjuvant Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Advanced Oesophageal Cancer Study to Compare Quality of Life and Palliation of Dysphagia.
Status: COMPLETED
Conditions: Esophagus Cancer
Interventions: DRUG: Cisplatin|RADIATION: Radiotherapy|DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TCR-Redirected T Cell Infusion in Subject With Recurrent HBV-related HCC Post Liver Transplantation
Status: UNKNOWN
Conditions: Recurrent Hepatocellular Carcinoma
Interventions: BIOLOGICAL: Biological: TCR-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil/Leucovorin Versus Sorafenib in Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Liver Cancer|Hepatic Carcinoma
Interventions: DRUG: FOLFOX regimen|DRUG: Sorafenib 200Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Enhanced Recovery Protocol in Urogynecologic Surgery
Status: COMPLETED
Conditions: Urinary Incontinence|Cystocele|Rectocele|Pelvic Organ Prolapse
Interventions: PROCEDURE: Enhanced recovery after surgery (ERAS) protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ustekinumab or Guselkumab in Pediatric Participants With Active Juvenile Psoriatic Arthritis
Status: RECRUITING
Conditions: Arthritis, Juvenile
Interventions: DRUG: Ustekinumab|DRUG: Guselkumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Liraglutide or Exenatide Added to an Ongoing Treatment on Blood Glucose Control in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of 68Ga-LNC1007 Injection PET/CT
Status: NOT_YET_RECRUITING
Conditions: Healthy Volunteers|Cancer Patients
Interventions: DRUG: 68Ga-LNC1007 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Series of Neoadjuvant Chemoradiotherapy Combined With Immunotherapy for Locally Advanced Rectal Cancer: From a Multicenter Phase II Cohort to a Phase III Randomized Controlled Study
Status: RECRUITING
Conditions: Locally Advanced Rectal Carcinoma
Interventions: DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cancer Predisposition Testing by Family-based Whole-genome Sequencing (WGS) in Every Child With Newly Diagnosed Cancer
Status: RECRUITING
Conditions: Neoplastic Syndromes, Hereditary|Cancer|Genetic Predisposition to Disease
Interventions: DIAGNOSTIC_TEST: Family-based whole genome sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Spine Bone Cements Outcomes - Post Market Follow-up
Status: RECRUITING
Conditions: Vertebral Fracture|Compression Fracture|Osteoporotic Fractures
Interventions: DEVICE: Vertebroplasty (VP)|DEVICE: Kyphoplasty (KP)|DEVICE: Pedicular Screw Augmentation (PSA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CSD190102: A Study to Assess Nicotine Pharmacokinetic Parameters After Use of Two Smokeless Tobacco Products
Status: COMPLETED
Conditions: Tobacco Use
Interventions: OTHER: A19010-R|OTHER: B19010-O
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Promoting Maintenance of Change Following Brief Intervention for Alcohol Use
Status: NOT_YET_RECRUITING
Conditions: Alcohol Drinking in College
Interventions: BEHAVIORAL: Parent handbook|BEHAVIORAL: Coping with negative emotions|BEHAVIORAL: Problem-solving risky situations|BEHAVIORAL: Recovering from slips
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The T REX Pilot Study: a Study to Investigate the Use of an Alternative Anaesthetic in Infants.
Status: COMPLETED
Conditions: Surgical Procedures, Operative
Interventions: DRUG: Dexmedetomidine|DRUG: Remifentanil|DRUG: Bupivacaine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effect of Acupuncture on Pain Relief Using Quantitative Sensory Testing (QST)
Status: COMPLETED
Conditions: Pain
Interventions: OTHER: Acupuncture|OTHER: Sham Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Early Percutaneous Cryoablation for Pain Control After Rib Fractures Among Elderly Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Rib Fractures
Interventions: RADIATION: Cryoneurolysis|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spanish Series of Patients Treated With the Radionuclide Lutetium177
Status: RECRUITING
Conditions: Neuroendocrine Tumors|Intestinal Neoplasms|Pancreatic Neoplasms|Stomach Neoplasms|Neuroectodermal Tumors|Neoplasms, Germ Cell and Embryonal|Neoplasms by Histologic Type|Neoplasms|Neoplasms, Nerve Tissue|Gastrointestinal Neoplasms|Digestive System Neoplasms|Neoplasms by Site|Endocrine Gland Neoplasms|Digestive System Diseases|Gastrointestinal Disease|Intestinal Diseases|Pancreatic Disease|Endocrine System Diseases
Interventions: DRUG: Lutetium [177Lu] oxodotreotide/dotatate|DEVICE: Lutetium [177Lu] oxodotreotide/dotatate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Testing the Efficacy of ACT for Life
Status: ENROLLING_BY_INVITATION
Conditions: Suicide
Interventions: BEHAVIORAL: ACT for Life|BEHAVIORAL: Present Centered Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Urinary Continence and Quality of Life in Prostate Cancer Patients
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: BEHAVIORAL: BF+SUPPORT|BEHAVIORAL: BF+PHONE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Finding Study of Pioglitazone in Children With Autism Spectrum Disorders (ASD) (PIO)
Status: COMPLETED
Conditions: Autism Spectrum Disorders
Interventions: DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation and Upper Respiratory Tract Infections in Adolescent Swimmers
Status: COMPLETED
Conditions: Upper Respiratory Tract Infections
Interventions: DIETARY_SUPPLEMENT: vitamin D|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Open-Label Study of AB-729, Nucleos(t)Ide Analogue and Pegylated Interferon Alfa-2a in Subjects With Chronic Hepatitis B Infection
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Hepatitis b
Interventions: DRUG: AB-729|DRUG: Peg-IFNα-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Duration of Effect of Bimatoprost SR in Participants With Open-Angle Glaucoma or Ocular Hypertension
Status: ACTIVE_NOT_RECRUITING
Conditions: Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Bimatoprost (SR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception
Status: RECRUITING
Conditions: Pain, Burning|Capsaicin
Interventions: OTHER: Cowhage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intraoperative Methadone vs Morphine for Postoperative Pain Control in Patients Undergoing Surgery of the Tibia
Status: TERMINATED
Conditions: Pain, Postoperative
Interventions: DRUG: Methadone|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of of Lebrikizumab Treatment in Adults and Adolescents With Moderate-to-Severe Atopic Dermatitis
Status: RECRUITING
Conditions: Dermatitis, Atopic|Eczema
Interventions: BIOLOGICAL: Lebrikizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yttrium Y 90 Basiliximab and Combination Chemotherapy Before Stem Cell Transplant in Treating Patients With Mature T-cell Non-Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma|Recurrent Mature T- and NK-Cell Non-Hodgkin Lymphoma|Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma|Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma|Refractory Cutaneous T-Cell Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: Yttrium Y 90 Basiliximab|DRUG: Carmustine|DRUG: Etoposide|DRUG: Cytarabine|DRUG: Melphalan|PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Colour Temperature of Reading Lamp on Refractive Error Development
Status: RECRUITING
Conditions: Refractive Errors
Interventions: DEVICE: 3000K Reading lamp|DEVICE: 4500K Reading lamp|DEVICE: 6500K Reading lamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nasally Delivered Pulmozyme for Sinusitis in Cystic Fibrosis
Status: COMPLETED
Conditions: Sinusitis|Cystic Fibrosis
Interventions: DRUG: Pulmozyme (dornase alfa)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Association of Macular Pigment Optical Density (MPOD) and Genetic Variants in Complement Factor H in Subjects With Choroidal Neovascular (CNV)
Status: COMPLETED
Conditions: Age-related Macular Degeneration|Choroidal Neovascular Age-related Macular Degeneration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p