pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Stress Reduction Training to Improve Sleep Quality, Stress Physiology & Cardiovascular Disease (CVD) Risk Markers
Status: COMPLETED
Conditions: Stress, Psychological|Sleep|Inflammation|Cardiovascular Diseases
Interventions: BEHAVIORAL: Mindfulness Based Stress Reduction (MBSR)|BEHAVIORAL: Mindfulness-Based Stress Reduction (MBSR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Medical Nutrition Therapy Plus Transgestational Metformin For Preventing Gestational Diabetes In High Risk Mexican Women
Status: COMPLETED
Conditions: Pregestational Obesity (BMI > 27kg/m2)|History of Polycystic Ovary Syndrome
Interventions: DRUG: medical nutrition therapy + metformin|BEHAVIORAL: Medical nutrition therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: L-tetrahydropalmatine (30mg)|DRUG: Sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab+mVPDL for CD20(+) Adult Acute Lymphoblastic Leukemia
Status: UNKNOWN
Conditions: Precursor Cell Lymphoblastic Leukemia-Lymphoma
Interventions: DRUG: Rituximab+mVPDL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of IVIG on Cerebral and Retinal Amyloid in Mild Cognitive Impairment Due to Alzheimer Disease
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BIOLOGICAL: Octagam 10%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Docetaxel-PNP and Taxotere to Treat Patient With Advanced Solid Cancer
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: Docetaxel-PNP|DRUG: Taxotere
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogenic Bone Marrow Mesenchymal Stem Cell Therapy in Acute-on-chronic Liver Failure
Status: TERMINATED
Conditions: Acute on Chronic Hepatic Failure
Interventions: BIOLOGICAL: Allogenic mesenchymal stem cells|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Prewarming on Microcirculatory Response
Status: COMPLETED
Conditions: Coronary Artery Bypass Graft Triple Vessel
Interventions: DEVICE: prewarming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Scalpel Versus Diathermy Skin Incision in Repeated CS
Status: COMPLETED
Conditions: Benifits of Using Diathermy in Skin Incision
Interventions: PROCEDURE: skin incision with a scalpel|PROCEDURE: skin incision with diathermy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Control Network Neuromodulation to Enhance Cognitive Training in Complex Traumatic Brain Injury
Status: RECRUITING
Conditions: Traumatic Brain Injury
Interventions: DEVICE: rTMS|DEVICE: HD-tDCS|OTHER: Attention Process Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hiatal Interrogation in Sleeve Gastrectomy
Status: TERMINATED
Conditions: Sleeve Gastrectomy
Interventions: PROCEDURE: Sleeve Gastrectomy Without Interrogation of Hiatus|PROCEDURE: Sleeve Gastrectomy With Interrogation of Hiatus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Ertugliflozin and Sitagliptin Co-administration Factorial Study (VERTIS FACTORAL, MK-8835-005)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Matching Placebo to Ertugliflozin 5 mg|DRUG: Matching Placebo to Ertugliflozin 10 mg|DRUG: Matching Placebo to sitagliptin 100 mg|DRUG: Ertugliflozin 5 mg|DRUG: Ertugliflozin 10 mg|DRUG: Sitagliptin 100 mg|DRUG: Metformin >= 1500 mg/day|BIOLOGICAL: Insulin Glargine Rescue Medication|DRUG: Glimepiride Rescue Medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CPB Versus Sham Treatment for Pain Management in Small Duct Chronic Pancreatitis
Status: COMPLETED
Conditions: Chronic Pancreatitis
Interventions: PROCEDURE: Celiac Plexus Block|PROCEDURE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Usefulness of Neutrophil Gelatinase-associated Lipocalin(NGAL) to Confirm Acute Kidney Function Decrease of the Patients Who Had Non-cardiac Surgery
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: OTHER: The level of NGAL after pre op,post op 4hr, post op 12hr
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of RP-3500 (Camonsertib) With Niraparib or Olaparib in Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumor, Adult
Interventions: DRUG: RP-3500 (camonsertib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic Supplementation on Sport Performance and Gut Damage in Females
Status: COMPLETED
Conditions: Sport Performance|Gut Damage
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Efficacy and Safety of FX006 in Patients With Hip Osteoarthritis
Status: TERMINATED
Conditions: Osteoarthritis, Hip
Interventions: DRUG: FX006|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Cohort Study of 4,837 Post-myocardial Infarction Patients (Alpha Omega Cohort)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases|Mortality|Type 2 Diabetes Mellitus|Cognitive Decline|Mental Well-being|Kidney Function
Interventions: BEHAVIORAL: Dietary intake|BEHAVIORAL: Lifestyle factors|BIOLOGICAL: Blood biomarkers|BIOLOGICAL: Health|GENETIC: DNA|BIOLOGICAL: Mental well-being
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Inactive and Active Vitamin D on Serum Sclerostin/dickkopf1 Levels
Status: UNKNOWN
Conditions: Osteoporosis
Interventions: DRUG: Calcitriol|DRUG: Alfacalcidol|DRUG: Cholecalciferol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydrocortisone Therapy Optimization During Hypothermia Treatment in Asphyxiated Neonates
Status: RECRUITING
Conditions: Hypoxic-Ischemic Encephalopathy|Asphyxia|Hypotension|Circulatory Failure Neonatal
Interventions: DRUG: Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Transplantation With Identical Donors for Patients With Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: Busulfan, Cyclophosphamide, Horse ATG|PROCEDURE: Allogeneic stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterisation of Gut Microbiota in Patients Undergoing Gastrointestinal Surgery With Postoperative Delirium (GIM-POD)
Status: NOT_YET_RECRUITING
Conditions: Postoperative Delirium|Gut Microbiota
Interventions: DRUG: General anesthetic
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects o Laughing Qigong Program on Psychological Outcomes and the Physiological Immunological Responses
Status: COMPLETED
Conditions: Breast Cancer Survivors
Interventions: BEHAVIORAL: The principle of laughter plus Qigong
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Integration of PE & Coping Long-Term With Active Suicide Program for PTSD & Suicide Risk in Military Families
Status: WITHDRAWN
Conditions: Post Traumatic Stress Disorder|Suicidal Ideation
Interventions: BEHAVIORAL: CLASP-PE arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melanole, a Dietary Supplement, for the Treatment of Gastroesophageal Reflux Disease
Status: UNKNOWN
Conditions: GERD
Interventions: DIETARY_SUPPLEMENT: Melanole for GERD treatment|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of the Booster Dose of Polio Vaccine With Different Primary Sequential Schedules in China
Status: COMPLETED
Conditions: Polio|Vaccine Reaction
Interventions: BIOLOGICAL: vaccinated with Sabin IPV|BIOLOGICAL: vaccinated with bOPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effects of a Mediterranean Diet in Pediatric Hyperlipidemia
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DIETARY_SUPPLEMENT: Omega-3 fatty acid (Eicosapentaenoic acid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Safety and Efficacy of an NAD+ Boosting Product Together With a Low Carbohydrate Diet in Adults With Mild Hypertension and Eligible for Normal-standard-of-care
Status: COMPLETED
Conditions: Hypertension
Interventions: OTHER: Limitless
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pain Results According to Pressure to Form Pneumoperitoneum
Status: UNKNOWN
Conditions: Cholecystitis|Postoperative Pain
Interventions: PROCEDURE: robotic single port cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effects of Naproxcinod and Naproxen on Blood Pressure Measurements in Osteoarthritis Patients With Controlled High Blood Pressure
Status: COMPLETED
Conditions: Osteoarthritis|Hypertension
Interventions: DRUG: naproxcinod 375 mg -750 mg -1125 mg bid|DRUG: naproxen 250 mg - 500mg -750 mg bid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of a Triclosan-containing Toothpaste During the Progression of Experimental Peri-implant Mucositis
Status: COMPLETED
Conditions: Biological Markers; Dental Implants; Cytokines; Triclosan; Toothpastes; Peri-Implantitis; Microbiology
Interventions: OTHER: Placebo toothpaste|OTHER: triclosan/copolymer/fluoride toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation on the Effects of Two Rehabilitation Treatment and Tape for Functional and Motor Recovery of LBP Patients
Status: RECRUITING
Conditions: Low Back Pain|Orthopedic Disorder|Physical Therapy|Core Strengthening|Rehabilitation
Interventions: OTHER: Rehabilitation - core strengthening|OTHER: Rehabilitation - rehabilitation pilates|OTHER: Elastic taping application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Azilsartan Compared to Olmesartan Medoxomil in Chinese Participants With Grade I or II Essential Hypertension
Status: UNKNOWN
Conditions: Essential Hypertension
Interventions: DRUG: azilsartan|DRUG: Olmesartan medoxomil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Supportive Effects of Craniosacral Therapy for Female Patients With Breast Cancer and Their Partners
Status: RECRUITING
Conditions: Breast Cancer|Complementary Therapies
Interventions: PROCEDURE: Craniosacral therapy|PROCEDURE: Craniosacral self-help group training|PROCEDURE: Treatment as usal / wait list
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Low-intensity Laser and Photodynamic Therapy on Infected Dentin of Permanent Teeth With MIH
Status: COMPLETED
Conditions: Molar Incisor Hypomineralization
Interventions: RADIATION: aPDT|PROCEDURE: ART
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Global BurdEn of MechanIcal VeNtilatIon (GEMINI). VeNtilatIon (GEMINI Study) 2022 for VENTILAGROUP.
Status: RECRUITING
Conditions: Mechanical Ventilation|Usual Care|Noninvasive Positive Pressure Ventilation|High Flow Oxygen Therapy
Interventions: OTHER: no intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Biomarker-driven Intermittent Docetaxel in Metastatic Castration-resistant Prostate Cancer
Status: RECRUITING
Conditions: Castration Resistant Prostatic Cancer
Interventions: DRUG: Docetaxel intermittent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronos: the Use of Chronobiological Treatment in Depression
Status: COMPLETED
Conditions: Major Depression
Interventions: PROCEDURE: Sleep deprivation|PROCEDURE: Light therapy|PROCEDURE: Diurnal rhythms|BEHAVIORAL: Exercise|DRUG: duloxetine|DRUG: duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continuos Terlipressin Infusion in Septic Shock
Status: UNKNOWN
Conditions: Septic Shock
Interventions: DRUG: Terlipressin|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Smartphone Application Self-management Programme on Clinical Health Outcomes in Patients With Chronic Obstructive Pulmonary Disease.
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: Smartphone application self-management programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Dipeptidyl-peptidase IV (DPP-IV) RO4876904 in Patients With Type 2 Diabetes.
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: Placebo|DRUG: RO4876904
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Asymptomatic Colonization With S. Aureus After Therapy With Linezolid or Clindamycin for Acute Skin Infections
Status: TERMINATED
Conditions: Skin Diseases, Bacterial|Abscess
Interventions: BIOLOGICAL: Linezolid|BIOLOGICAL: Clindamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Therapy Based on Attenuated ATO Plus Low-Dose ATRA in Patients With APL
Status: RECRUITING
Conditions: Promyelocytic Leukemia
Interventions: DRUG: Arsenic trioxide|DRUG: all-trans retinoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alzheimer's Disease: Clinical Investigation and Neuroimage Studies Including 18F-PM-PBB3 and 18F-florbetapir (AV-45) PET Examination
Status: UNKNOWN
Conditions: Alzheimer's Disease
Interventions: DRUG: F-18 PMPBB3|DRUG: 18F-florbetapir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Perioperative Pregabalin for Reducing Opioid Consumption After Cardiac Surgery
Status: TERMINATED
Conditions: Opioid Use
Interventions: DRUG: Pregabalin 300 mg|DRUG: Pregabalin 75 mg|DRUG: Pregabalin 300 mg Placebo|DRUG: Pregabalin 75 mg Placebo|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TEPStabil - Muscle Function and Dynamic and Postural Stability in Patients Receiving Hip or Knee Arthroplasty
Status: COMPLETED
Conditions: Postural Stability
Interventions: DIAGNOSTIC_TEST: Muscle strength test|DIAGNOSTIC_TEST: Dynamic stability test during level and uphill walking|DIAGNOSTIC_TEST: Postural stability test|DIAGNOSTIC_TEST: EuroQol Group Health questionnaire (EQ-5D-5L)|DIAGNOSTIC_TEST: HOOS/ KOOS|DIAGNOSTIC_TEST: Muscle activity test|DIAGNOSTIC_TEST: Passive range of motion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety of Rituximab Retreatment in Subjects With Systemic Lupus Erythematosus
Status: TERMINATED
Conditions: Lupus Erythematosus, Systemic
Interventions: DRUG: Rituximab|DRUG: Methylprednisolone|DRUG: Acetaminophen|DRUG: Diphenhydramine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dyslexia, Motor Control and Proprioception
Status: TERMINATED
Conditions: Dyslexia
Interventions: BEHAVIORAL: Evaluation of proprioception|BEHAVIORAL: Evaluation of motor learning|BEHAVIORAL: Evaluation of written language
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Initial Screening of Gemfibrozil as a Novel Treatment for Tobacco Addiction
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: DRUG: Gemfibrozil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of DVD Education on Physical Activity and Self Management of Heart Failure
Status: TERMINATED
Conditions: Heart Failure
Interventions: BEHAVIORAL: Allied Health Education Class Option|OTHER: Physiotherapy treatment intervention on referral|DEVICE: Keeping the Beat with Physiotherapy: Heart Failure edition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brentuximab Vedotin and Combination Chemotherapy in Treating Older Patients With Previously Untreated Stage II-IV Hodgkin Lymphoma
Status: UNKNOWN
Conditions: Adult Lymphocyte Depletion Hodgkin Lymphoma|Adult Lymphocyte Predominant Hodgkin Lymphoma|Adult Mixed Cellularity Hodgkin Lymphoma|Adult Nodular Sclerosis Hodgkin Lymphoma|Stage II Adult Hodgkin Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage IV Adult Hodgkin Lymphoma
Interventions: DRUG: brentuximab vedotin|DRUG: doxorubicin hydrochloride|DRUG: vinblastine|DRUG: dacarbazine|PROCEDURE: quality-of-life assessment|GENETIC: DNA analysis|GENETIC: RNA analysis|RADIATION: fludeoxyglucose F 18|PROCEDURE: positron emission tomography|OTHER: laboratory biomarker analysis|OTHER: immunohistochemistry staining method|GENETIC: polymorphism analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effectiveness of Kinesio Taping and Knee Orthosis in Patients With Patellofemoral Pain Syndrome
Status: COMPLETED
Conditions: Patellofemoral Pain Syndrome|Anterior Knee Pain Syndrome|Patellofemoral Pain|Patellofemoral Syndrome|Orthotic Devices|Kinesiotape
Interventions: PROCEDURE: Kinesio taping|PROCEDURE: Orthosis|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Docetaxel, 5-Fluorouracil and Oxaliplatin in Adenocarcinoma of the Stomach or Gastroesophageal Junction Patients
Status: COMPLETED
Conditions: Gastrointestinal Diseases
Interventions: DRUG: 5-Fluorouracil|DRUG: Docetaxel|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of ARNi in Ventricular Remodeling in Hypertensive LVH
Status: RECRUITING
Conditions: Hypertensive Heart Disease
Interventions: DRUG: Entresto|DRUG: Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: Methylprednisolone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mesalamine Granules for Irritable Bowel Syndrome (IBS) With Diarrhea
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Diarrhea
Interventions: DRUG: Placebo|DRUG: Mesalamine Granules 750 mg|DRUG: Mesalamine Granules 1500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Levels of Two Antibiotics in the Blood When Given Together and Separately
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CAZ104|DRUG: Avibactam|DRUG: Ceftazidime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: ULTRAPREP Used to Perform Skin Antisepsis Outside the Operating Room
Status: COMPLETED
Conditions: Time Saved Performing Skin Antisepsis Process Outside the OR|Antisepsis of Skin Preparation Outside the OR
Interventions: DEVICE: ULTRAPREP|DEVICE: No Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prophylaxis Covid-19 in Healthcare Agents by Intensive Treatment With Ivermectin and Iota-carrageenan
Status: COMPLETED
Conditions: Covid19|SARS (Severe Acute Respiratory Syndrome)
Interventions: DRUG: Ivermectin / Iota-Carrageenan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Reduced Intensity AlloSCT in(CML) With Persistent Disease
Status: TERMINATED
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Reduced Intensity Conditioning, Busulfan and Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Bevacizumab and Carboplatin Followed by Concurrent Bevacizumab, Carboplatin and Radiotherapy in the Primary Treatment of Cervix Cancer
Status: WITHDRAWN
Conditions: Cervical Cancer
Interventions: DRUG: Bevacizumab|DRUG: Carboplatin|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monoclonal Antibody Therapy Plus Etoposide in Treating Patients With Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: BIOLOGICAL: monoclonal antibody 3F8|DRUG: etoposide|DRUG: isotretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Tauroursodeoxycholic Acid in Prophylactic Therapy of Total Parenteral Nutrition Associated Cholestasis in Infants
Status: COMPLETED
Conditions: Cholestasis
Interventions: DRUG: tauroursodeoxycholic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Intra-ductal Confocal Endomicroscopy for Characterization of Pancreas and Bile Duct Tumor
Status: COMPLETED
Conditions: Pancreas Neoplasms|Bile Duct Diseases
Interventions: PROCEDURE: Endoscopic Retrograde Cholangio-Pancreatography (ERCP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of PFS and ART in Adhesive Capsulitis in Diabetic Patients
Status: COMPLETED
Conditions: Adhesive Capsulitis
Interventions: OTHER: Post facilitation stretch|OTHER: Active release technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Leukine (Sargramostim) for Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: sargramostim|DRUG: placebo|DIAGNOSTIC_TEST: Sham Comparator: Controls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Immunogenicity of INO-4800 for COVID-19 in Healthy Volunteers
Status: COMPLETED
Conditions: Coronavirus Infection
Interventions: DRUG: INO-4800|DEVICE: CELLECTRA® 2000
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison Of The Immediate Effects Of Manipulation On The Autonomic Nervous System
Status: COMPLETED
Conditions: Vagus Nerve Autonomic Disorder
Interventions: OTHER: Supine practice group|OTHER: Prone application group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Immunogenicity of a Live Attenuated Human Metapneumovirus Vaccine
Status: COMPLETED
Conditions: Metapneumovirus
Interventions: BIOLOGICAL: 10^6 PFU rHMPV-Pa vaccine|BIOLOGICAL: 10^5 PFU rHMPV-Pa vaccine|BIOLOGICAL: Placebo Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Vasoactive Effects of IQP-AS-118 in Healthy Individuals
Status: WITHDRAWN
Conditions: Blood Flow|Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: IQP-AS-118|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of The Effects of Initial Oral Feeding by Cup and Bottle-Feeding of Preterm Infants
Status: COMPLETED
Conditions: Oxygen Saturation|Heart Rate|Nutritional Status
Interventions: BEHAVIORAL: Cup feeding|BEHAVIORAL: Bottle feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Taxane Therapy With or Without Bavituximab for the Treatment of HER2-Negative Metastatic Breast Cancer
Status: WITHDRAWN
Conditions: Metastatic Breast Cancer
Interventions: BIOLOGICAL: Bavituximab|DRUG: Taxane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypertonic Lactate After Cardiac Arrest
Status: NOT_YET_RECRUITING
Conditions: Cardiac Arrest|Ischemia Reperfusion Injury|Anoxic Brain Injury
Interventions: DRUG: Sodium Lactate Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MIcronized PROgesterone in Frozen Embryo Transfer Cycles
Status: RECRUITING
Conditions: Infertility
Interventions: DRUG: Vaginal progesterone 600mg daily|DRUG: Vaginal progesterone 800mg daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FIRSTx - A Study of Oral CXA-10 in Primary Focal Segmental Glomerulosclerosis (FSGS)
Status: COMPLETED
Conditions: Primary Focal Segmental Glomerulosclerosis
Interventions: DRUG: CXA-10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Enhancement on Working Memory in Patients With Schizophrenia
Status: COMPLETED
Conditions: Memory Deficits|Schizophrenia|Neurostimulator; Complications
Interventions: DEVICE: STARSTIM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Analysis for the ClotTriever Catheter to Investigate Safety and Effectiveness in the Treatment of Acute and Subacute Iliofemoral Deep Vein Thrombosis (DVT)
Status: COMPLETED
Conditions: Deep Vein Thrombosis
Interventions: DEVICE: ClotTriever Catheter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Magrolimab Combinations in Participants With Myeloid Malignancies
Status: COMPLETED
Conditions: Myeloid Malignancies
Interventions: DRUG: Magrolimab|DRUG: Azacitidine|DRUG: Venetoclax|DRUG: Mitoxantrone|DRUG: Etoposide|DRUG: Cytarabine|DRUG: CC-486
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Passive and Active Vibration Therapy on Grip Strength and Myoelectric Activity
Status: UNKNOWN
Conditions: Strength
Interventions: PROCEDURE: Vibration with flexion|PROCEDURE: Vibration without flexion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nutrition for Colorectal Cancer Patients and Neutrophil Functions
Status: COMPLETED
Conditions: Malnutrition|Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: Standard (Kabiven)|DIETARY_SUPPLEMENT: Standard-Glutamine|DIETARY_SUPPLEMENT: Standard-Omega 3 fatty acid|DIETARY_SUPPLEMENT: Standard-glutamine-omega 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: RELIEF: Randomized Episodic Versus Long-Term Suppression Experience With Famciclovir
Status: COMPLETED
Conditions: Recurrent Genital Herpes (RGH)
Interventions: DRUG: Famciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of a Colonoscopy Monitoring Program on Endoscopists' Performance
Status: NOT_YET_RECRUITING
Conditions: Adenoma Colon Polyp|Sessile Serrated Adenoma
Interventions: OTHER: Colonoscopy monitoring program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effect of Serotonergic Stimulation on the Gut-brain Axis
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy|Irritable Bowel Syndrome
Interventions: OTHER: serotonergic stimulation|OTHER: no serotonergic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of NN1250 in Subjects With Type 2 Diabetes of Different Race and/or Ethnic Origin
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec|DRUG: insulin detemir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Insulin - Utility and Results in Neurotrophic Keratopathy in Stages 2 and 3
Status: COMPLETED
Conditions: Corneal Ulcer|Corneal Perforation|Corneal Epithelium Defect|Neurotrophic Keratitis
Interventions: DRUG: Topical Insulin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase IIa Dose-ranging Study of GSK1349572 in HIV-1 Infected Adults
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: GSK1349572|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Decision Making in Chronic Pain and Alcohol Use Disorder
Status: RECRUITING
Conditions: Alcohol Use Disorder|Chronic Pain
Interventions: BEHAVIORAL: Episodic Future Thinking|BEHAVIORAL: Control Episodic Thinking|DEVICE: Low-intensity Focused Ultrasound|DEVICE: Sham Low-intensity Focused Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Vonoprazan Versus Intravenous Proton Pump Inhibitors for Prevention of Rebleeding in High Risk Peptic Ulcers Bleeding After Successful Endoscopic Hemostasis
Status: COMPLETED
Conditions: Peptic Ulcer With Haemorrhage
Interventions: DRUG: Vonoprazan|DRUG: PPIs IV infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of Immunotherapy to Treat Advanced Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Ipilimumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of MET vs Mulligan MWM on Pain, Disability & Balance in Athletes With Ankle Sprain
Status: UNKNOWN
Conditions: Chronic Ankle Sprain
Interventions: OTHER: post isometric relaxation|OTHER: MWM group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Compare Robotically Assisted Radical Cystectomy With Open Radical Cystectomy
Status: UNKNOWN
Conditions: Bladder Cancer
Interventions: PROCEDURE: Intracorporeal Robot Assisted Radical Cystectomy|PROCEDURE: Open Radical Cystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk-Guided Cardioprotection With Carvedilol in Breast Cancer Patients Treated With Doxorubicin and/or Trastuzumab
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiotoxicity|Risk Factor, Cardiovascular|Toxicity Due to Chemotherapy|Breast Cancer|Cardiomyopathies|Heart Failure
Interventions: DRUG: Carvedilol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Protective Effects of Propranolol in Adults
Status: TERMINATED
Conditions: Burn
Interventions: DRUG: Propranolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GRT9906 Prolonged Release Tablets After Dose Escalation in Healthy Subjects
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: GRT9906 PR tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: Isoquercetin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Statin Therapy in Asymptomatic Aortic Stenosis
Status: UNKNOWN
Conditions: Aortic Valve Stenosis
Interventions: DRUG: fluvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Male Subjects to Investigate the Comparability of Pharmacokinetics of the Fixed-Dose Combination of Pertuzumab and Trastuzumab Administered Subcutaneously Using a Handheld Syringe or Using the On-Body Delivery System
Status: COMPLETED
Conditions: Healthy Male Subjects
Interventions: DRUG: Fixed-Dose Combination of Pertuzumab and Trastuzumab SC (PH FDC SC)|DEVICE: Handheld Syringe with Hypodermic Needle|DEVICE: On-Body Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Exercise in the Management of Peripheral Neuropathy
Status: COMPLETED
Conditions: Chemotherapy-induced Peripheral Neuropathy|Chemotherapeutic Toxicity
Interventions: OTHER: Hand-foot exercise|OTHER: The routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetic Study of Oral Testosterone (T) Ester Formulations in Hypogonadal Men
Status: COMPLETED
Conditions: Hypogonadism
Interventions: DRUG: Oral testosterone undecanoate (TU) (300 mg T equivalents/dose)|DRUG: Oral testosterone undecanoate (TU) combined with testosterone enanthate (TE) (400 mg T equivalents/dose)|DRUG: Oral testosterone undecanoate (TU) (200 mg T equivalents/dose with and without food)|DRUG: Oral testosterone undecanoate (TU) combined with testosterone enanthate (TE) (300 mg T equivalents/dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Dose Esketamine and Dexmedetomidine for Supplemental Analgesia and Longterm Outcomes
Status: NOT_YET_RECRUITING
Conditions: Scoliosis Correction|Postoperative Analgesia|Esketamine|Dexmedetomidine|Chronic Postsurgical Pain
Interventions: DRUG: Esketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MOdification Of THe Early-Life Respiratory Microbiome Through Vaginal SEEDing
Status: RECRUITING
Conditions: Cesarean Section|Vaginal Seeding|Nose|Microbiome
Interventions: PROCEDURE: Vaginal Seeding|PROCEDURE: Sterile Swab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer
Status: COMPLETED
Conditions: Cervical Adenocarcinoma|Cervical Adenosquamous Carcinoma|Cervical Small Cell Carcinoma|Cervical Squamous Cell Carcinoma|Stage IB Cervical Cancer|Stage IIA Cervical Cancer|Stage IIB Cervical Cancer|Stage III Cervical Cancer|Stage IVA Cervical Cancer
Interventions: RADIATION: Internal Radiation Therapy|RADIATION: 3-Dimensional Conformal Radiation Therapy|BIOLOGICAL: Cetuximab|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OPC5: Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) in Patients With Malignant Pleural Effusion.
Status: RECRUITING
Conditions: Malignant Pleural Effusion|Pleural Neoplasms|Quality of Life|Chemotherapy Effect|Chemotherapeutic Toxicity|Pleural Carcinomatosis|Pleural Cavity Effusion
Interventions: DRUG: PITAC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intensity Modulated Radiation Therapy With Cisplatin and Gemcitabine to Treat Locally Advanced Cervical Carcinoma
Status: COMPLETED
Conditions: Cervical Carcinoma
Interventions: RADIATION: Intensity Modulated Radiation Therapy (IMRT)|DRUG: Cisplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Administration of Human Chorionic Gonadotrophin Before Secretory Transformation of Frozen-thawed Embryo Transfer Cycles
Status: COMPLETED
Conditions: hCG|FET|Frozen-thawed Embryo Transfe|Human Chorionic Gonadotrophin
Interventions: DRUG: Human Chorionic Gonadotrophin Intramuscular injection 10.000 IU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HER2 PET Imaging in Breast Cancer Patients Using [68GA]ABY-025
Status: TERMINATED
Conditions: HER2-positive Breast Cancer
Interventions: OTHER: Radiolabeled [68Ga]ABY-025
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Inspiratory Muscle Training in Elders
Status: COMPLETED
Conditions: Muscular Atrophy|Sensitivity Training Groups|Aging
Interventions: OTHER: Inspiratory muscle training|OTHER: Training sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant FOLFOX6 Chemotherapy With or Without Radiation in Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: DRUG: fluorouracil|DRUG: fluorouracil, oxaliplatin|DRUG: fluorouracil, oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of the Combination of AL-335, Odalasvir, and Simeprevir
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: AL-335|DRUG: Odalasvir (ODV)|DRUG: Simeprevir (SMV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of VX-661 in Combination With Ivacaftor in Subjects Aged 12 Years and Older With Cystic Fibrosis, Heterozygous for the F508del-CFTR Mutation
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: VX-661 plus ivacaftor combination|DRUG: Ivacaftor|DRUG: Placebo (matched to VX-661 plus ivacaftor combination)|DRUG: Placebo (matched to ivacaftor)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH)
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Macitentan|OTHER: Standard-of-care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CPAP Device In-lab Assessment NZ
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Auto CPAP + comfort feature A|DEVICE: Auto CPAP with comfort feature B|DEVICE: Auto CPAP with no comfort feature|DEVICE: Auto CPAP with comfort feature A+B|DEVICE: CPAP with comfort feature A|DEVICE: CPAP with comfort feature B|DEVICE: CPAP with no comfort feature|DEVICE: CPAP with comfort feature A + B|DEVICE: CPAP at Sub therapeutic level
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Medial Versus Lateral Approach in Ultrasound (US)-Guided Supraclavicular Block
Status: COMPLETED
Conditions: Hand or Arm Surgery
Interventions: PROCEDURE: Lateral-to-Medial Approach|PROCEDURE: Media-to-Lateral Approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Infusion of NatuRal KillEr celLs or MEmory T Cells as Adoptive Therapy in COVID-19 pnEumonia or Lymphopenia
Status: COMPLETED
Conditions: Corona Virus Infection
Interventions: BIOLOGICAL: T memory cells and NK cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intraperitoneal Analgesia in Pediatric Laparoscopy
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: Dexmedetomidine|DRUG: Magnesium Sulfate|DRUG: Normal saline 0.9 %
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Altaire Gel Forming Solution Versus Refresh Tears for the Treatment of Dry Eye Signs and Symptoms
Status: UNKNOWN
Conditions: Dry Eye Syndromes
Interventions: DRUG: Altaire Gel forming solution|DRUG: Refresh Tears
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT