pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Irinotecan and Capecitabine as Second-line Treatment for Advanced/Metastatic Biliary Tract Cancers
Status: WITHDRAWN
Conditions: Biliary Tract Cancer
Interventions: DRUG: Irinotecan & Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Acadesine On Reducing Cardiovascular and Cerebrovascular Adverse Events In Coronary Artery Bypass Graft (CABG) Surgery (Study P05633 AM1)(TERMINATED)
Status: TERMINATED
Conditions: Coronary Artery Bypass|Myocardial Infarction|Ventricular Dysfunction, Left|Stroke|Cardiopulmonary Bypass
Interventions: DRUG: Acadesine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PRospective Evaluation of Interstitial Lung DIsease Progression With Quantitative CT
Status: ENROLLING_BY_INVITATION
Conditions: Interstitial Lung Disease
Interventions: DIAGNOSTIC_TEST: HRCT Thorax|DEVICE: Glycocheck Endothelial Glycocalyx Assessment|DIAGNOSTIC_TEST: Blood biomarkers|DIAGNOSTIC_TEST: Peripheral leucocyte telomere length|DIAGNOSTIC_TEST: Pulmonary function testing|DIAGNOSTIC_TEST: Patient reported outcome measures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Atezolizumab and Cobimetinib in Treating Patients With Metastatic, Recurrent, or Refractory Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Lung Non-Small Cell Carcinoma|Recurrent Lung Non-Small Cell Carcinoma|Refractory Lung Non-Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8
Interventions: DRUG: Atezolizumab|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Cobimetinib|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Building the Path to Resilience in Preterm Infants: Mindfulness-based Intervention
Status: ACTIVE_NOT_RECRUITING
Conditions: Preterm Birth|Cognitive Dysfunction|Behavioral Problem
Interventions: BEHAVIORAL: Mindfulness-based intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Use of Mangosteen Juice Added to Usual Care in Reducing Risk of Recurrent Atrial Fibrillation
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: DRUG: mangosteen juice|DRUG: placebo juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Bevacizumab With or Without Radiation Therapy in Treating Patients With Locally Advanced Rectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dual Joint Visual Feedback Gait Retraining in Pediatric Hemiplegic Cerebral Palsy
Status: UNKNOWN
Conditions: Hemiplegic Cerebral Palsy
Interventions: DEVICE: Dual Joint Visual Feedback without Scoring|DEVICE: Dual Joint Visual Feedback with Scoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: FOLFOX-Cetuximab-radiotherapy for the Treatment of Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer Stage III
Interventions: DRUG: radiochemotherapy,combination Cetuximab-FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Detection and Paramedical Care of Sexual Difficulties in Nervous System Diseases: Example of Multiple Sclerosis and Brain Tumors (NEUROSEX)
Status: UNKNOWN
Conditions: Low Grade Glioma of Brain|Multiple Sclerosis|Sexual Dysfunctions
Interventions: OTHER: Paramedical care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clobetasol Propionate Ophthalmic Nanoemulsion 0.05% for the Treatment of Inflammation and Pain Associated With Cataract Surgery (CLOSE-1)
Status: COMPLETED
Conditions: Cataract
Interventions: DRUG: Clobetasol propionate|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Fruquintinib Plus Chemotherapy as Second-line Treatment in Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Fruquintinib+ chemotherapy|DRUG: Bevacizumab+ chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test BI 767551 in People With Mild to Moderate Symptoms of COVID-19
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: BI 767551 intravenous|DRUG: BI 767551 inhaled|DRUG: Placebo intravenous|DRUG: Placebo inhaled
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Long-term Safety and Effectiveness Evaluation of the QDOT MICRO System Use in Conjunction With VISITAG SURPOINT Module for the Treatment of Symptomatic Drug Refractory Paroxysmal Atrial Fibrillation.
Status: RECRUITING
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: Ablation Procedure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Anti-PD-1 +/- RT for MSI-H Solid Tumors
Status: WITHDRAWN
Conditions: Microsatellite Instability High|Mismatch Repair Deficiency|Colorectal Cancer
Interventions: COMBINATION_PRODUCT: RT and Anti-PD-1|DRUG: Anti-PD-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of JP-1366 in Patients With Gastric Ulcer
Status: COMPLETED
Conditions: Gastric Ulcer
Interventions: DRUG: JP-1366 20mg|DRUG: Lansoprazole 30mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Trial of the Efficacy and Safety of Diclegis® for Nausea and Vomiting of Pregnancy in Pregnant Adolescents
Status: TERMINATED
Conditions: Morning Sickness
Interventions: DRUG: Diclegis|DRUG: Placebo (Sugar Pill)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proton Therapy for Stage I Non-Small Cell Lung Cancer (LU03)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: RADIATION: Peripherally located lung tumor|RADIATION: Centrally located lung tumor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Sleep Apnea Assessment Strategies to Maximize TBI Rehabilitation Participation and Outcome
Status: COMPLETED
Conditions: Apnea, Sleep|Brain Injury, Traumatic
Interventions: DEVICE: Polysomnography - Level 1 and Level 3|DEVICE: Actigraphy monitoring|OTHER: Sleep Apnea Screening
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lateral Pharyngoplasty Outcomes in Children Undergoing Tonsillectomy
Status: RECRUITING
Conditions: Sleep-Disordered Breathing|Sleep Apnea Syndromes in Children|Sleep Apnea, Obstructive|Tonsillitis|Tonsillar Hypertrophy|Tonsil Stone|Tonsil Disease
Interventions: PROCEDURE: Lateral pharyngoplasty|PROCEDURE: Tonsillectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study With Peginterferon, Ribavirin, and Boceprevir Prior to Transplantation to Clear Virus in Hepatitis C Genotype 1 Infected Individuals Undergoing Orthotopic Liver Transplantation
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: DRUG: boceprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Venovenous Hemodiafiltration Versus Sustained Low-efficiency Hemodialysis for Critically Ill Patients With Acute Kidney Injury in Intensive Care Unit
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: PROCEDURE: Slow efficiency dialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Relative Bioavailability of 3 Different Formulations Under Fasted and Fed Condition
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Verinurad ER8 capsule formulation (fasted)|DRUG: Verinurad A-capsule formulation (fasted)|DRUG: Verinurad A-capsule formulation (fed)|DRUG: Verinurad B-capsule formulation (fasted)|DRUG: Verinurad B-capsule formulation (fed)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Efgartigimod for Thymoma and Myasthenia Gravis
Status: NOT_YET_RECRUITING
Conditions: Myasthenia Gravis
Interventions: DRUG: Efgartigimod Alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease
Status: RECRUITING
Conditions: Liver Cirrhosis|Portal Hypertension|Surgery|Acute-On-Chronic Liver Failure|Non-Cirrhotic Portal Hypertension
Interventions: OTHER: No Intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The DURABLE Trial: Evaluating the Durability of Starter Insulin Regimens in Patients With Type 2 Diabetes (IOOV)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin glargine|DRUG: Lispro Low Mix|DRUG: Lispro Mid Mix|DRUG: Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Efficacy and Safety of Cartistem and Microfracture in Patients With Knee Articular Cartilage Injury
Status: COMPLETED
Conditions: Cartilage Injury|Osteoarthritis
Interventions: BIOLOGICAL: Cartistem|PROCEDURE: Microfracture treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Axillary Venous Cannulation in Pediatrics
Status: COMPLETED
Conditions: Ultrasound Guided Central Venous Cannulation
Interventions: DEVICE: landmark|DEVICE: US_Ax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Different Ventilatory Strategy During Bronchoscopy
Status: NOT_YET_RECRUITING
Conditions: Bronchoscopy
Interventions: DEVICE: Conventional Oxygen Therapy|DEVICE: High-flow nasal oxygen|DEVICE: Supraglottic jet oxygenation and ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Endoscopic Papillary Large Balloon Dilation on Recurrent Rate of Patients With Recurrentstones in Bile Duct
Status: COMPLETED
Conditions: Endoscopic Papillary Large Balloon Dilation
Interventions: PROCEDURE: endoscopic papillary large balloon dilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Electrical Acupoint Stimulation for Postoperative Recovery
Status: UNKNOWN
Conditions: Postoperative Complications|Postoperative Nausea and Vomiting|Postoperative Infection|Postoperative Delirium|Postoperative Pneumonia|Deep Vein Thrombosis|Postoperative Retention of Urine|Postoperative Recovery
Interventions: DEVICE: Transcutaneous Electrical Acupoint Stimulation|DEVICE: Electroacupuncture|DEVICE: sham Transcutaneous Electrical Acupoint Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of the Bilateral Sequential and Simultaneous Cochlear Implantation in the Deaf Children
Status: WITHDRAWN
Conditions: Deafness
Interventions: PROCEDURE: bilateral cochlear Implantation in sequential|PROCEDURE: bilateral cochlear Implantation in simultaneous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The IGNITE for Kids Study on Concentrated Investment in Black Neighborhoods and Child Health and Well-Being
Status: ACTIVE_NOT_RECRUITING
Conditions: Financial Stress|Economic Problems|Environmental Exposure|Health Behavior|Health, Subjective|Mental Health Wellness
Interventions: OTHER: Assigned Interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Natalizumab (BG00002, Tysabri) Study in Japanese Participants With Relapsing-Remitting Multiple Sclerosis (RRMS)
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Natalizumab (BG00002)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modulation of Adjuvant 5-FU by Folinic Acid and Interferon-alpha in Colon Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DRUG: Folinic Acid, interferon-alpha
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Atezolizumab as Neoadjuvant and Adjuvant Therapy in Resectable Non-Small Cell Lung Cancer (NSCLC) - Lung Cancer Mutation Consortium (LCMC3)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Atezolizumab (MPDL3280A), an engineered anti-PD-L1 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Multimodal Pain Regimen on Pain Control, Patient Satisfaction and Narcotic Use in Orthopaedic Trauma Patients
Status: WITHDRAWN
Conditions: Post Operative Pain Control
Interventions: DRUG: Gabapentin|DRUG: Acetaminophen|DRUG: Acetaminophen|DRUG: Celecoxib|DRUG: Dexamethasone|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary Vaccination Course in Children Receiving the Pneumococcal Vaccine GSK 1024850A, Zilbrix™ Hib and Polio Sabin™
Status: COMPLETED
Conditions: Infections, Streptococcal
Interventions: BIOLOGICAL: GSK Biologicals' Synflorix™|BIOLOGICAL: GSK Biologicals' Polio Sabin™|BIOLOGICAL: GSK Biologicals' Zilbrix™ Hib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase I Study to Assess the Tolerability of 225Ac-DOTATATE in Patients With Refractory and Relapsing Multiple Myeloma Expressing Somatostatin Receptors
Status: NOT_YET_RECRUITING
Conditions: Multiple Myeloma, Refractory|Multiple Myeloma in Relapse|Multiple Myeloma Progression
Interventions: DRUG: 225Ac-DOTATATE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-Residue Diet in Treating Diarrhea in Patients Receiving Pelvic Radiation Therapy.
Status: COMPLETED
Conditions: Cervical Cancer|Diarrhea|Prostate Cancer|Radiation Toxicity|Sarcoma
Interventions: DIETARY_SUPPLEMENT: dietary intervention|PROCEDURE: management of therapy complications|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of BIIB019 (Daclizumab High Yield Process) Versus Interferon β 1a in Participants With Relapsing-Remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing-Remitting Multiple Sclerosis
Interventions: BIOLOGICAL: BIIB019 (Daclizumab High Yield Process)|DRUG: Interferon beta-1a Placebo|BIOLOGICAL: Interferon beta-1a|DRUG: Daclizumab High Yield Process Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of Gilteritinib and Momelotinib for Patients With Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Myeloid Leukemia
Interventions: DRUG: Gilteritinib|DRUG: Momelotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Naltrexone for Opioid Dependent Released Human Immunodeficiency Virus Positive (HIV+) Criminal Justice Populations
Status: COMPLETED
Conditions: HIV|AIDS|Opioid Dependence|Drug Dependence
Interventions: DRUG: Extended-Release Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Aorta Adaptations to Exercise in Triathletes During Sports Season (CoATri)
Status: COMPLETED
Conditions: Stiffness, Aortic|Cardiac Remodeling, Ventricular|Vascular Remodeling|Magnetic Resonance Imaging, Functional|Athletes
Interventions: DEVICE: Cardiac MRI|DEVICE: Applanation tonometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Abusers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Placebo|DRUG: intact ALO-02 60 mg/7.2 mg|DRUG: crushed ALO-02 60 mg/7.2 mg|DRUG: crushed oxycodone IR 60 mg|DRUG: crushed ALO-02 40 mg/4.8 mg|DRUG: crushed oxycodone IR 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Impact of Multidisciplinary Self-care Management of Diabetic Nephropathy on Quality of Life, Self-care Behavior, Glycemic Control, and Renal Function.
Status: COMPLETED
Conditions: Diabetic Kidney Disease
Interventions: BEHAVIORAL: Self-care management program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Interactions Between Cranberry Juice and Antibiotics Used to Treat Urinary Tract Infections
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: DRUG: Cranberry juice|DRUG: Amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in People With Neurofibromatosis Type 1 (NF1) Mutated Gastrointestinal Stromal Tumors (GIST)
Status: WITHDRAWN
Conditions: Neoplasms, Nerve Tissue|Neurofibromatosis 1|Heredodegenerative Disorders, Nervous System|Peripheral Nervous System Diseases
Interventions: DRUG: Selumetinib (AZD6244 hyd sulfate) 50mg/dose|DRUG: Selumetinib (AZD6244 hyd sulfate) 25mg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Epitope Peptide To Treat HLA-A*02 Disease Controlled Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: HLA-A*0201restricted URLC10 peptides with adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S9005 Mifepristone in Meningioma
Status: COMPLETED
Conditions: Meningioma
Interventions: DRUG: Mifepristone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Liraglutide in Subjects With Type 1 Diabetes Undergoing Islet Cell Transplantation
Status: TERMINATED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Natural Killer Cells' Ability to Kill Leukemia Cells and the Outcome of Patients With Acute Myeloid Leukemia Previously Treated With Interleukin-2
Status: COMPLETED
Conditions: Leukemia
Interventions: OTHER: flow cytometry|OTHER: immunologic technique|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exploratory Study to Evaluate 2 Acupuncture Methods for the Treatment of Headaches Associated With TBI
Status: COMPLETED
Conditions: Headache|Traumatic Brain Injury
Interventions: PROCEDURE: Traditional Chinese Acupuncture (TCA)|PROCEDURE: Auricular (Ear) Acupuncture|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Testing the Effect of Ivacaftor on Lung Function in Subjects With Cystic Fibrosis and Residual CFTR Function
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Ivacaftor|DRUG: Placebo-matched-to-ivacaftor tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Sympathetic Overactivity in Post-traumatic Stress Disorder
Status: RECRUITING
Conditions: Post-traumatic Stress Disorder|Prehypertension
Interventions: DEVICE: Device-Guided Breathing (DGB)|DEVICE: Sham DGB|DEVICE: Transcutaneous Vagal Nerve Stimulation (tVNS)|DEVICE: Sham tVNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Bioavailability Study of Sebacoyl Dinalbuphine Ester IM Injection in Healthy Volunteers
Status: COMPLETED
Conditions: Pain|Analgesia Disorder
Interventions: DRUG: Bain®|DRUG: SDE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Intramuscular Olanzapine and Intramuscular Haloperidol in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Olanzapine Hydrochloride|DRUG: Haloperidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Precision-T: A Randomized Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Acute Lymphoid Leukemia|Mixed Phenotype Acute Leukemia|Undifferentiated Leukemia|Myelodysplastic Syndrome|Acute Leukemia|Therapy-Related Myelodysplastic Syndrome
Interventions: BIOLOGICAL: Orca-T|BIOLOGICAL: Standard-of-Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mood and Nutrition Interventions in Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome (PCOS)
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Nutrition Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A PD-1 Checkpoint Inhibitor (Cemiplimab) for High-Risk Localized, Locally Recurrent, or Regionally Advanced Skin Cancer
Status: RECRUITING
Conditions: Recurrent Skin Squamous Cell Carcinoma|Resectable Skin Squamous Cell Carcinoma|Stage I Skin Cancer|Stage II Skin Cancer|Stage III Skin Cancer
Interventions: BIOLOGICAL: Cemiplimab|PROCEDURE: Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AR-42 and Decitabine in Treating Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Recurrent Adult Acute Myeloid Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: HDAC inhibitor AR-42|DRUG: decitabine|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study on the Use of Nociceptive Flexion Reflex for Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess Efficacy, Safety and Tolerability of the Anti-IL-13 Monoclonal Antibody QAX576 in the Treatment of Perinanal Fistulas in Patients Suffering From Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: QAX567
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Enhanced Smoking Cessation Intervention for Smokers Exposed to the World Trade Center (WTC) Disaster
Status: COMPLETED
Conditions: Cigarette Smoking|Post Traumatic Stress Disorder|Signs and Symptoms, Respiratory
Interventions: BEHAVIORAL: CBT-A|BEHAVIORAL: CBT-S
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Autologous Platelet-rich Plasma on Knee Cartilage Injury
Status: COMPLETED
Conditions: Cartilage Injury
Interventions: DRUG: autologous platelet-rich plasma|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Qizhiweitong Granule on Patients With Functional Dyspepsia in a Multi-center Clinical Study
Status: COMPLETED
Conditions: Functional Dyspepsia
Interventions: DRUG: Qizhiweitong granule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Volume-controlled and Pressure-controlled Ventilation in Clasp-knife Position
Status: COMPLETED
Conditions: Mechanical Ventilation|General Anesthesia|Urological Surgery|Robotic Surgery
Interventions: BEHAVIORAL: record Hemodynamic variables, respiratory variables and arterial blood gas at specific times
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dialysis Performance of Different Dialyzer Membranes Using Different Coagulation Strategies
Status: COMPLETED
Conditions: Hemodialysis|Coagulation
Interventions: DEVICE: choice of dialyzer|OTHER: choice of dialysis mode|OTHER: choice of anticoagulation strategy|OTHER: preparation of dialyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
Status: RECRUITING
Conditions: Crohn's Disease
Interventions: DRUG: IV Tulisokibart|DRUG: SC Tulisokibart|OTHER: IV Placebo|OTHER: SC Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interaction Between a Natural Aldehyde Dehydrogenase 2 (ALDH2) Inhibitor and Alcohol
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Daidzin|DIETARY_SUPPLEMENT: Alcohol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to Methotrexate
Status: ACTIVE_NOT_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Abatacept|DRUG: Adalimumab|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anatomic Congruent Prosthetic Knee Design
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Cruciate Retaining|DEVICE: Medial Congruent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing Tumor Response and IMRT Treat Plan After IC Based on FDG-PET/CT for Locally Advanced HNSCC
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: RADIATION: IMRT|RADIATION: PET/CT|DRUG: Docetaxel|DRUG: Fluorouracil|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Oral Oteseconazole (VT-1161) for the Treatment of Patients With Recurrent Vaginal Candidiasis (Yeast Infection)
Status: COMPLETED
Conditions: Recurrent Vulvovaginal Candidiasis
Interventions: DRUG: Oteseconazole (VT-1161)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Paravertebral Nerve Blockade to Reduce Pain Following Thoracoscopy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Paravertebral nerve blockade|PROCEDURE: Intercostal nerve blockade|PROCEDURE: Patient Controlled Analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Effectiveness of CNTO 888 Administered Intravenously (IV) in Participants With Idiopathic Pulmonary Fibrosis (IPF)
Status: COMPLETED
Conditions: Pulmonary Fibrosis
Interventions: DRUG: Placebo|DRUG: CNTO 888 1 mg/kg|DRUG: CNTO 888 5 mg/kg|DRUG: CNTO 888 15 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Toripalimab Plus Radiotherapy for Elderly Esophageal Cancer Patients Treated With Non-chemotherapy Strategy
Status: RECRUITING
Conditions: Esophageal Cancer|Radiation Therapy|Immunotherapy|Chemotherapy
Interventions: DRUG: Toripalimab|DRUG: Tegafur|RADIATION: IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of a Tele-game-based Exercise (Tele-exergame) Program to Prevent Deconditioning in Hospitalized COVID-19 Patients
Status: COMPLETED
Conditions: COVID 19|Rehabilitation|Inpatient|Hospitalized
Interventions: OTHER: Tele-exergaming Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: M-mode Ultrasonography in the Assessment and Treatment of Pelviperineal Dysfunctions (PerineUM)
Status: NOT_YET_RECRUITING
Conditions: Pelvic Floor Disorders
Interventions: OTHER: Electromyographic biofeedback|OTHER: M-mode US biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2, Dose Finding Study of PF-03187207 in Patients With Primary Open Angle Glaucoma or Ocular Hypertension.
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: PF-03187207|DRUG: Latanoprost 0.005%|DRUG: PF-03187207 Vehicle|DRUG: Latanoprost Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D, Chronic Kidney Disease (CKD) and the Microcirculation
Status: COMPLETED
Conditions: Chronic Kidney Disease|Vitamin D Deficiency
Interventions: DRUG: Ergocalciferol (Vitamin D)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interactive Effects of Mindfulness and Slow-paced Breathing
Status: COMPLETED
Conditions: Stress|Stress, Psychological|Stress Physiology|Sleep|Slow Breathing
Interventions: BEHAVIORAL: Slow-Paced Breathing (SPB)|BEHAVIORAL: Mindfulness (M)|BEHAVIORAL: Yogic Breathing (SPB+M)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of DLBS1033 After Primary PCI in Patients With STE-ACS
Status: TERMINATED
Conditions: ST Elevation Myocardial Infarction
Interventions: DRUG: DLBS1033|DRUG: Placebo|DRUG: Standard therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TAK-020 Relative Bioavailability and Food Effect Study in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: TAK-020 Captisol Oral Solution|DRUG: TAK-020 CCT|DRUG: TAK-020 SDT|DRUG: TAK-020 IRT|DRUG: TAK-020 CCT|DRUG: TAK-020 Solid Formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: P03277 Dose Finding Study in Central Nervous System (CNS) Magnetic Resonance Imaging (MRI)
Status: COMPLETED
Conditions: CNS Lesion|Blood Brain Barrier Defect
Interventions: DRUG: P03277|DRUG: Gadobenate dimeglumine|DEVICE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Informing Pain Treatment Using Pharmacogenomic Analysis
Status: NOT_YET_RECRUITING
Conditions: Analgesia|Cancer|CYP2D6
Interventions: OTHER: Pharmacogenomic (PGx) results.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Is Plasma Transfusion Beneficial Prior to Low-Risk Procedures in Hospitalized Patients With Blood Clotting Abnormalities?
Status: COMPLETED
Conditions: Blood Coagulation, Disorders|Surgical Procedures, Minimally Invasive
Interventions: DRUG: Fresh Frozen Plasma Transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: LIVING - Physical Activity in a Self-management Program Among Persons With Type 2 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2|Randomized Controlled Trial
Interventions: BEHAVIORAL: Lev Livet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Liposomal Doxorubicin Followed By Bexarotene in Treating Patients With Cutaneous T-Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Targretin® (bexarotene)|DRUG: pegylated liposomal doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wean Obese Study : Determination of the Optimal Spontaneous Breathing Trial for Obese Patient
Status: COMPLETED
Conditions: Obesity|Respiratory Failure|PSV 7cmH2O PEEP 7cmH2O|PSV 7 cmH2O PEEP 0 cmH20|CPAP 7 cmH2O|PSV 0 cmH20 PEEP 0 cmH2O|T-Tube|Post-extubation in Spontaneous Breathing and/or in NIV
Interventions: PROCEDURE: Spontaneous breathing trial
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dosing of Methadone for Spine Surgery
Status: RECRUITING
Conditions: Pain, Postoperative
Interventions: DRUG: Standard dosing of methadone|DRUG: Aliquots of methadone titrated to apnea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Blinded Safety & Efficacy Placebo Controlled Study of Icatibant for Angiotensin Converting Enzyme Inhibitor Induced Angioedema
Status: COMPLETED
Conditions: Angiotensin Converting Enzyme Inhibitor Induced Angioedema
Interventions: DRUG: Icatibant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Mucosal Resection for the Diagnosis of a-Ganglionosis, a Controlled Prospective Trial (EDGE Trial)
Status: COMPLETED
Conditions: Constipation|Hirschsprung Disease
Interventions: PROCEDURE: Endoscopic mucosal resection (EMR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pneumococcal Vaccination in Patients With Chronic Lymphocytic Leukaemia
Status: UNKNOWN
Conditions: Pneumococcal Infections|Chronic Lymphocytic Leukemia|Vaccine-Preventable Diseases|Invasive Pneumococcal Disease, Recurrent Isolated
Interventions: BIOLOGICAL: Prevnar13
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Non-invasive Mechanical Ventilation as a Rescue Therapy to Relieve Dyspnea in Patients With Stable Severe COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: niv plus oxygen therapy|DEVICE: oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Navitoclax and Sorafenib Tosylate in Treating Patients With Relapsed or Refractory Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Cirrhosis|Hepatitis B Infection|Hepatitis C Infection|Metastatic Malignant Solid Neoplasm|Recurrent Hepatocellular Carcinoma|Recurrent Malignant Solid Neoplasm|Refractory Malignant Neoplasm|Stage IV Hepatocellular Carcinoma AJCC v7|Unresectable Solid Neoplasm
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Navitoclax|OTHER: Pharmacological Study|DRUG: Sorafenib|DRUG: Sorafenib Tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing SingLe- Vs Multi-Fraction Spine STereotActic Radiosurgery in Spinal Metastases
Status: RECRUITING
Conditions: Spinal Metastases
Interventions: RADIATION: Single-fraction spine SRS|RADIATION: Multi-fraction spine SRS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of PF-04965842 Effect on Rosuvastatin Pharmacokinetics in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-04965842|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Safety of Collecting and Combining Autologous Hematopoietic Stem Cells With Chimeric Antigen Receptor (CAR) T-Cell Therapy in Subjects With Relapsed/Refractory Hematological Malignancies
Status: RECRUITING
Conditions: Hematologic Malignancy|Large B-cell Lymphoma|Acute Lymphoblastic Leukemia|Mantle Cell Lymphoma|Multiple Myeloma|Diffuse Large B Cell Lymphoma
Interventions: BIOLOGICAL: autologous hematopoietic stem cells added to planned CAR T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of CD-008-0045 in Patients With Generalized Anxiety Disorder
Status: UNKNOWN
Conditions: Anxiety Disorder Generalized
Interventions: DRUG: CD-008-0045|DRUG: Placebo|DRUG: Afobazol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Lactose in Patients With Chronic Liver Disease and Minimal Hepatic Encephalopathy
Status: TERMINATED
Conditions: Hepatic Encephalopathy|Liver Cirrhosis
Interventions: DIETARY_SUPPLEMENT: Lactose-free milk|DIETARY_SUPPLEMENT: Whole milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: T-Cell Repertoire Sequencing: Assessing Pembrolizumab Efficacy in Advanced Non-small Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer Metastatic
Interventions: DRUG: Pembrolizumab 50 MG Injection [Keytruda]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Aging Brain ANSWERS Program
Status: COMPLETED
Conditions: Traumatic Brain Injury|Alzheimer Disease|Veterans|Family Caregivers|Caregiver Burden|Quality of Life
Interventions: OTHER: ABC ANSWERS|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Tivantinib in Subjects With Inoperable Hepatocellular Carcinoma (HCC) Who Have Been Treated With One Prior Therapy
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Tivantinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Contrast Enhanced Transrectal Ultrasonography (TRUS) to Assess Prostatic Vascularity After Radiotherapy (XRT)
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Contrast Enhanced-Transrectal Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Adalimumab in Japanese Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Double-blind adalimumab|DRUG: Double-blind Placebo|BIOLOGICAL: Open-label Adalimumab|BIOLOGICAL: Open-labelAdalimumabRescue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of a Reduced Immunosuppression vs. Standard Triple Therapy in Senior Renal Transplant Recipients
Status: UNKNOWN
Conditions: Immunosuppression After Renal Transplantation
Interventions: OTHER: Reduced immunosuppression|DRUG: Tacrolimus|DRUG: mycophenolate|DRUG: Steroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Milademetan and Fulvestrant in GATA3-mutant, ER+HER- Advanced or Metastatic Breast Cancer
Status: TERMINATED
Conditions: Advanced or Metastatic Breast Cancer
Interventions: DRUG: Milademetan|BEHAVIORAL: Patient Reported Outcomes (PROs) and Health-Related Quality of Life (HRQOL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cervical Ripening With a Double-lumen Balloon Catheter for Six Versus Twelve Hours
Status: COMPLETED
Conditions: Induction of Labor Affected Fetus / Newborn
Interventions: DEVICE: Double-lumen balloon catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of "Crohn's Disease-TReatment-with-EATing" Diet and Exclusive Enteral Nutrition on Healthy Gut Bacteria
Status: COMPLETED
Conditions: Crohn's Disease|Dietary Modification
Interventions: OTHER: Exclusive Enteral Nutrition (EEN)|OTHER: Crohn's Disease TReatment-with-EATing diet (CD-TREAT diet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: In Vivo Effects of Amylase Trypsin Inhibitors
Status: NOT_YET_RECRUITING
Conditions: Non-Coeliac Wheat Sensitivity (NCWS)|Irritable Bowel Syndrome
Interventions: OTHER: Amylase trypsin inhibitors|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Gastrointestinal Quality of Life Study in Lung Transplant Recipients Converted From Mycophenolate Mofetil to Myfortic
Status: TERMINATED
Conditions: Lung Transplantation
Interventions: BEHAVIORAL: GI and Quality of Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER