pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of Pembrolizumab (MK-3475) in Combination With Chemotherapy or Immunotherapy in Participants With Non-small Cell Lung Cancer (MK-3475-021/KEYNOTE-021)
Status: COMPLETED
Conditions: Non-small Cell Lung Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Paclitaxel|DRUG: Carboplatin|BIOLOGICAL: Bevacizumab|DRUG: Pemetrexed|BIOLOGICAL: Ipilimumab|DRUG: Erlotinib|DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-escalation Study to Assess Selumetinib Safety, Tolerability and PK
Status: COMPLETED
Conditions: Healthy Volunteers Pharmacokinetic Study
Interventions: DRUG: Selumetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study In Healthy People To Evaluate Safety, Toleration And Time Course Of Plasma Concentration Of Multiple Oral Doses Of PF-04895162
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-04895162|DRUG: PF-04895162|DRUG: PF-04895162|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Regional Anesthesia Techniques on Brain Tissue Oxygenation in Thoracic Surgery
Status: COMPLETED
Conditions: Thoracic Surgery|Epidural Anesthesia|Cerebral Oxygen Saturation
Interventions: DEVICE: Regional oximetry probe|PROCEDURE: Thoracic Epidural block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Mindfulness to Improve Functional Outcomes in Patients With Fibromyalgia or Central Sensitization
Status: TERMINATED
Conditions: Chronic Pain|Fibromyalgia|Central Sensitisation
Interventions: BEHAVIORAL: BreathAware for Pain Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Irinotecan, 5-Fluorouracil, and Leucovorin in Colorectal Carcinoma
Status: COMPLETED
Conditions: Colorectal Carcinoma
Interventions: DRUG: Irinotecan|DRUG: 5-Fluorouracil|DRUG: Leucovorin|DRUG: Tetrathiomolybdate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dual Therapy With Raltegravir and Darunavir/Ritonavir in HIV Infected Patients.
Status: COMPLETED
Conditions: Integrase Inhibitors, HIV; HIV PROTEASE INHIB
Interventions: DRUG: Raltegravir|DRUG: Darunavir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Risk of Chemotherapy Toxicity in Older Patients With Blood Cancer or Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Lung Non-Small Cell Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Cognitive Assessment|OTHER: Physical Performance Testing|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance and Safety of Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Unknown Primary Head and Neck Cancer (ILLUMINATE STUDY)
Status: RECRUITING
Conditions: Head and Neck Cancer|Unknown Primary Cancer|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Pegsitacianine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Tolerability, Safety and Immunogenicity Trial of the Flu-M Tetra Vaccine in Children
Status: RECRUITING
Conditions: Influenza|Influenza, Human|Influenza Viral Infections|Vaccine Reaction
Interventions: BIOLOGICAL: Influenza vaccine [inactivated]|BIOLOGICAL: Influenza vaccine [inactivated]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial to Evaluate the Efficacy and Security of Deep Brain Stimulation in Alzheimer´s Disease
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: DEVICE: Deep brain stimulation (fornix)|DEVICE: Deep brain stimulation (Basal nucleus of Meynert)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SBRT Followed by Neoadjuvant Immunochemotherapy in Resectable Stage II to III Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: RADIATION: SBRT|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk-factors for Multidrug-resistant Bacteria Colonization Among Patients at High Risk of STIs
Status: UNKNOWN
Conditions: Bacterial Infections|HIV Infections
Interventions: PROCEDURE: Inguinal swab sample|PROCEDURE: Anal swab sample|PROCEDURE: Fecal sample|OTHER: Risk factor assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Pancreatic Endoscopic Drainage on Exocrine Pancreatic Function in Unresectable Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Neoplasm Malignant Head Primary|Pancreatic Exocrine Insufficiency
Interventions: DEVICE: Pancreatic stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immobilization of Postoperative Distal Radius Fractures
Status: TERMINATED
Conditions: Distal Radius Fractures
Interventions: OTHER: Plaster Splint|OTHER: Velcro Brace|OTHER: Soft Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Optical Coherence Tomographic Findings After Balloon Angioplasty With Two Different Paclitaxel-Coated Balloons for the Treatment of In-Stent Restenosis in Drug-Eluting Stents
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: DEVICE: balloon angioplasty with Pantera Lux|DEVICE: balloon angioplasty with SeQuent Please
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Delivering iCBT to Address Mental Health Challenges in Correctional Officers and Other Public Safety Personnel
Status: RECRUITING
Conditions: Mental Health Issue|Anxiety Disorders|Depressive Disorder|Post-Traumatic Stress Disorder
Interventions: BEHAVIORAL: iCBT|BEHAVIORAL: In-Person CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Argan Spinosa Oil in the Treatment of Diaper Dermatitis in Infants and Toddlers
Status: COMPLETED
Conditions: Diaper Rash
Interventions: OTHER: The traditional medicinal product of Argan spinosa oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peritoneal Ultrafiltration in Cardio Renal Syndrome.
Status: NOT_YET_RECRUITING
Conditions: Congestive Heart Failure
Interventions: DRUG: PolyCore (Polydextrin, L-Carnitine, D-xylitol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ARVs to Prevent Breastmilk HIV:Viral and Immune Responses
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Combined short-course zidovudine/nevirapine|DRUG: HAART
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insulin Resistance and Intramyocellular Lipid Content in Glucose Intolerant Subjects Receiving Rosiglitazone
Status: COMPLETED
Conditions: Insulin Sensitivity
Interventions: DRUG: Rosiglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Gum Chewing on Bowel Motility in Post-operative Colon Resection Patients
Status: COMPLETED
Conditions: Colon Resection
Interventions: OTHER: gum chewing|OTHER: no gum chewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety and Efficacy of 25 mg Hydrocortisone Acetate Suppositories in Treatment of Internal Hemorrhoids
Status: COMPLETED
Conditions: Internal Hemorrhoids
Interventions: DRUG: Hydrocortisone Acetate Suppository, 25 mg (Nivagen)|DRUG: Placebo (Vehicle) Suppository (Nivagen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive-motor Training Post-stroke - a Pilot Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Stroke Sequelae|Motor Skills Disorders
Interventions: BEHAVIORAL: Visuomotor force control training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia
Status: COMPLETED
Conditions: General Anesthesia
Interventions: DRUG: HSK3486|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)
Status: RECRUITING
Conditions: Triple-Negative Breast Cancer
Interventions: BIOLOGICAL: Pembrolizumab|BIOLOGICAL: sac-TMT|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Perioperative Neuromuscular Training on the Outcome of Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DEVICE: APOS biomechanical gait system|PROCEDURE: Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Anxiety Assessment Intervention in Dental Patients
Status: COMPLETED
Conditions: Anxiety State
Interventions: BEHAVIORAL: Information to health provider without patient knowledge|BEHAVIORAL: dentist behaviour and patient expectancy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: HRV Biofeedback in Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia Syndrome
Interventions: BEHAVIORAL: RSA Biofeedback|BEHAVIORAL: EEG Biofeedback Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Testing MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Invasive Breast Carcinoma|Stage 0 Breast Cancer AJCC v6 and v7|Stage I Breast Cancer AJCC v7|Stage II Breast Cancer AJCC v6 and v7|Stage III Breast Cancer AJCC v7|Triple-Negative Breast Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Laboratory Biomarker Analysis|OTHER: Patient Observation|BIOLOGICAL: Pembrolizumab|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Ibalizumab Subcutaneous Injection in Healthy Volunteers
Status: COMPLETED
Conditions: Prevention of Infection With HIV-1
Interventions: BIOLOGICAL: ibalizumab (biologic/MAb) for SC Injection or placebo|BIOLOGICAL: ibalizumab (biologic/MAb) for SC Injection or placebo|BIOLOGICAL: ibalizumab (biologic/MAb) for SC Injection or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag
Status: COMPLETED
Conditions: Jet Lag
Interventions: DRUG: Hydrocortisone|DRUG: Melatonin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Coadministration of Oral Propranolol to Oxytocin on Induction of Labor
Status: UNKNOWN
Conditions: Poor; Labor
Interventions: DRUG: propranolol|DRUG: placebo|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Sunitinib Malate in Treating Patients With Uterine Cervical Cancer That is Stage IVB, Recurrent, or Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Cervical Adenocarcinoma|Cervical Adenosquamous Cell Carcinoma|Cervical Squamous Cell Carcinoma|Recurrent Cervical Cancer|Stage IVB Cervical Cancer
Interventions: DRUG: sunitinib malate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Proof of Concept Study to Evaluate the Efficacy and Tolerability of Microneedling With SkinPen in Female and Male Subjects With Facial Acne Vulgaris, Ages 18 Through 45
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DEVICE: Skinpen Prescision System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long-Term Safety Study of Org 50081 (Esmirtazapine) in Elderly Outpatients With Chronic Primary Insomnia (176005/P05697/MK-8265-001)
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorder; Elderly|Mental Disorder|Dyssomnias|Sleep Disorders|Sleep Disorder, Intrinsic
Interventions: DRUG: Esmirtazapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Clavipectoral Fascia Plane Block for Clavicle Surgery
Status: COMPLETED
Conditions: Clavicle Fracture|Clavicle Injury
Interventions: OTHER: Clavipectoral block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SOFI: A Quality Improvement Project to Standardize Use of Intravenous Fluids in Hospitalized Pediatric Patients
Status: COMPLETED
Conditions: Intravenous Fluids|Fluid and Electrolyte Imbalance|ADH Inappropriate
Interventions: OTHER: Education, clinical decision support tools
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Progesterone for Postpartum Cocaine Relapse
Status: COMPLETED
Conditions: Cocaine Abuse|Cocaine Dependence
Interventions: DRUG: Progesterone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-Inflammatory Effect of Statins in the Human Endotoxin Model
Status: COMPLETED
Conditions: Endotoxemia
Interventions: DRUG: LPS 2ng/kg intravenous bolus|DRUG: Simvastatin 80mg; administered daily p.o. over 5 days|DRUG: Rosuvastatin 40mg; administered daily p.o. over 5 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety and Performance of TAVI of Venus MedTech Aortic Valve Prosthesis
Status: UNKNOWN
Conditions: Aortic Valve Stenosis|Aortic Valve Calcification
Interventions: DEVICE: Venus MedTech Aortic Valve Prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-Arm Study To Evaluate The Efficacy and Safety of Valoctocogene Roxaparvovec in Hemophilia A Patients at a Dose of 4E13 vg/kg
Status: COMPLETED
Conditions: Hemophilia A
Interventions: BIOLOGICAL: Valoctocogene Roxaparvovec
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic,Safety and Exploratory Efficacy of RECTIV® in Adolescents With Chronic Anal Fissure
Status: WITHDRAWN
Conditions: Anal Fissure
Interventions: DRUG: Nitroglycerin Ointment 0.4%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SARS-COV-2 Seroprevalence and Seroconversion Among Employees of the Universitair Ziekenhuis Brussel Following mRNA COVID-19 Vaccination
Status: ACTIVE_NOT_RECRUITING
Conditions: SARS-CoV Infection
Interventions: DIAGNOSTIC_TEST: serological testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Computer Guided Buccal Cortical Plate Separation for Removal of Calcified Benign Odontogenic Tumors Affecting Mandibular Angle Region
Status: COMPLETED
Conditions: Odontogenic Tumors|Odontoma
Interventions: OTHER: Computer guided buccal cortical plate separation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Vocational Rehabilitation Group Intervention on Motivation and Occupational Self-Awareness in Individuals With Intellectual Disabilities
Status: COMPLETED
Conditions: Intellectual Disability
Interventions: OTHER: The Entering Employment and Sustaining Work Program|OTHER: vocational rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Prebiotics on Metagenomic Diversity and Abundance in Young Children With Acute Malnutrition
Status: NOT_YET_RECRUITING
Conditions: Child Malnutrition
Interventions: DIETARY_SUPPLEMENT: Prebiotic galacto-oligosaccharide (GOS) Powder|DIETARY_SUPPLEMENT: Starch Only|DIETARY_SUPPLEMENT: RUTF + Starch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of XELOX vs. Oxaliplatin+5-FU CI as First Line Treatment in Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: (capecitabine, oxaliplatin, 5-fluorouracil)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MASked-unconTrolled hypERtension Management Based on Office BP or on Out-of-office (Ambulatory) BP Measurement
Status: RECRUITING
Conditions: Masked Hypertension
Interventions: OTHER: Optimization of antihypertensive treatment based on office BP|OTHER: Optimization of antihypertensive treatment based on 24-hour ABPM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Different Low Volume Solutions Prior to Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: Natrium picosulfate / Magnesium citrate|DRUG: Polyethylene glycol / Ascorbic acid|DRUG: Natrium/ Kalium/ Magnesium sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Polydrug-Using Opiate Dependents During Withdrawal
Status: COMPLETED
Conditions: Opiate Dependence|Drug Dependence|Substance Withdrawal Syndrome
Interventions: DRUG: Buprenorphine|DRUG: Valproate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-dose, Randomised, Crossover, Placebo-controlled Study Assessing Two Fixed-dose Combinations of Inhaled Long-acting Beta-agonist and Corticosteroid
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: LAS40468|DRUG: Salmeterol/fluticasone propionate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allergy, Asthma, and Atopic Eczema in Finland
Status: NOT_YET_RECRUITING
Conditions: Asthma|Asthma in Children|Allergy|Rhinitis, Allergic|Atopic Dermatitis|Allergen Immunotherapy
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chlorhexidine & Pneumonia in Nursing Home Residents
Status: COMPLETED
Conditions: Pneumonia|Respiratory Infection
Interventions: DRUG: chlorhexidine|DRUG: Placebo mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Adding Simethicone to Split-dose Polyethylene Glycol for Bowel Preparation in a Screening Colonoscopy Setting
Status: COMPLETED
Conditions: Colo-rectal Cancer|Colonic Neoplasms
Interventions: DRUG: PEG split-dose and simethicone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: FLT-PET in Predicting Response to Chemotherapy in Patients With Advanced Malignancies
Status: COMPLETED
Conditions: Malignant Neoplasm
Interventions: DRUG: Fluorothymidine F-18|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine
Status: COMPLETED
Conditions: Depressive Disorder, Treatment-Resistant
Interventions: DRUG: Naltrexone|DRUG: Placebo|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Empower the Heart of Patients With Terminal Cancer Using Cardiac Medicines Trial
Status: RECRUITING
Conditions: Pre-terminal Cancer
Interventions: DRUG: Heart failure medication|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Flavopiridol in Treating Patients With Recurrent, Locally Advanced, or Metastatic Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Sarcoma
Interventions: DRUG: alvocidib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pediatric Taste Test Study of Omnicef Versus Zithromax Antibiotic Suspension Medications
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: cefdinir (Omnicef)|DRUG: azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Physiological and Appetitive Effects of CBD Supplementation
Status: RECRUITING
Conditions: Appetitive Behavior|Adverse Effect|Metabolic Health
Interventions: DIETARY_SUPPLEMENT: Cannabidiol (CBD) supplementation|DIETARY_SUPPLEMENT: Placebo supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Chronic Rhinosinusitis Symptoms in Asthma Patients Undergoing Treatment With Reslizumab
Status: WITHDRAWN
Conditions: Chronic Rhinosinusitis (Diagnosis)|Asthma|Nasal Polyps
Interventions: DRUG: Reslizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Oscillatory Versus Non-Oscillatory Nasal Continuous Airway Pressure Neonatal Respiratory Support
Status: WITHDRAWN
Conditions: Respiratory Distress Syndrome|Prematurity
Interventions: DEVICE: Nasal CPAP|DEVICE: Oscillatory NCPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Tadalafil 5 mg on Post-micturition Dribble in Young-age Men With no/Mild Lower Urinary Tract Symptoms
Status: UNKNOWN
Conditions: Lower Urinary Tract Symptoms
Interventions: DRUG: Tadalafil 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Effects of AZD9496 vs Fulvestrant in Breast Cancer.
Status: COMPLETED
Conditions: Postmenopausal Women With ER+ HER2- Primary Breast Cancer
Interventions: DRUG: Standard Arm - Fulvestrant|DRUG: AZD9496
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Propofol Only Sedation in Oral and Maxillofacial Surgery
Status: UNKNOWN
Conditions: Procedural Sedation|Propofol
Interventions: DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of TAF in Reducing Clinical Events in CHB Patients Beyond Treatment Indications by Current Guidelines
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Hepatitis b
Interventions: DRUG: Tenofovir Alafenamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Everolimus for Treating Pediatric Patients With Recurrent or Refractory Tumors
Status: COMPLETED
Conditions: Tumors|Brain Tumors|Rhabdomyosarcoma|Sarcoma, Soft Tissue
Interventions: DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Difference and Cause of Acupuncture Dexmedetomidine Compound Anesthesia Effect
Status: UNKNOWN
Conditions: Acupuncture|Dexmedetomidine|Anesthesia
Interventions: DEVICE: Dexmedetomidine+electroacupuncture compound anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Morphine Added to Ropivacaine for FICB for Postoperative Analgesia
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Ropivacaine, Morphine|DRUG: Ropivacaine, Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Development of Human Nasal Challenge Models With Microbial Constituents and Grass Pollen
Status: COMPLETED
Conditions: Allergic Rhinitis|Asthma|Latent Tuberculosis
Interventions: OTHER: Poly ICLC|OTHER: Poly I:C|OTHER: R848|OTHER: Timothy Grass Pollen|OTHER: Vitamin D|OTHER: Tuberculin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Observe the Effect of Mirapex ER® Once-daily (QD) Versus Twice-daily (BID)
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: DRUG: Mirapex ER
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pyrotinib Combined With Trastuzumab Subcutaneously Compared Intravenous Administration in the Treatment of HER2-positive Early Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: HER2+ Breast Cancer
Interventions: DRUG: Trastuzumab intravenous drip/Trastuzumab Subcutaneous Injection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Replacing Diet Beverages With Water on Weight Loss and Plasma Glucose Control in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes|Overweight|Obese
Interventions: BEHAVIORAL: DBs at the end of the main meal + Diet|BEHAVIORAL: Water at the end of the main meal+ Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Texture Modified Diets on Dietary Intake and Appetite Responses in Older Adults
Status: COMPLETED
Conditions: Older Adults
Interventions: BEHAVIORAL: Preload meals that are solid or texture modified and are fortified with protein or not fortified with protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Tislelizumab Combined With Chemotherapy With or Without Bevacizumab in TKI-Resistant EGFR-Mutated Non-squamous NSCLC
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Tislelizumab|DRUG: Carboplatin|DRUG: Pemetrexed|DRUG: Bevacizumab|DRUG: Nab paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Doses of GSK2256294 in Healthy Volunteers, and Single and Repeat Doses of GSK2256294 in Adult Male Moderately Obese Smokers
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK2256294|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacological Agents for Chronic Spinal Cord Injury (SCI)
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: DRUG: CPH + hand training|DRUG: CD-LD + hand training|DRUG: ATX + hand training|DRUG: Placebo + hand training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Grappler Interference Screw Post-Market Collection of Patient Reported Outcome Measures
Status: COMPLETED
Conditions: Ankle Injuries|Syndesmotic Injuries|Ankle Inversion Sprain|Deltoid Ankle Sprain|Achilles Tendon Rupture|Flexor Hallucis Longus on the Left|Flexor Hallucis Longus on the Right|Flexor Digitorum Longus on the Left|Flexor Digitorum Longus on the Right|Ankle Sprains
Interventions: DEVICE: Grappler Interference Screw System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Innate and Acquired Immunity to Influenza Infection and Immunization (SLVP029)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluzone®|BIOLOGICAL: FluMist®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized, Double-blind Study Comparing Tremelimumab to Placebo in Subjects With Unresectable Malignant Mesothelioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Unresectable Pleural or Peritoneal Malignant Mesothelioma
Interventions: DRUG: Tremelimumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Proteinuria and Renal Function in Diabetic Patients With Progressive Renal Disease
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Rosuvastatin|DRUG: Rosuvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retention Rate and Caries Preventive Effect of Preheated Flowable Resin Composite Used as a Pit and Fissure Sealant
Status: COMPLETED
Conditions: Pit and Fissure Sealant
Interventions: OTHER: Pre-heating of flowable resin composite used as a pit and fissure sealant.|OTHER: Conventional resin fissure sealant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cancer in Inherited Bone Marrow Failure Syndromes
Status: RECRUITING
Conditions: Diamond Blackfan Anemia|Dyskeratosis Congenita|Fanconi Anemia|Shwachman Diamond Syndrome|Inherited Bone Marrow Failure Syndrome, Aplastic Anemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lomecel-B Effects on Alzheimer's Disease
Status: COMPLETED
Conditions: Mild Alzheimer's Disease
Interventions: DRUG: Allogeneic MSC|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evidence Based Colorectal Cancer Screening for the Uninsured - Sub-study
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BEHAVIORAL: Control condition|BEHAVIORAL: Cost condition|BEHAVIORAL: Cost/Future condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Bacillus Coagulans on Liver and Gut Microbiota Function in NAFLD
Status: RECRUITING
Conditions: Effects of Bacillus Coagulans TCI711 Supplementation on Liver and Gut Microbiota Function in Non-alcoholic Fatty Liver Disease Patients
Interventions: DIETARY_SUPPLEMENT: Bacillus Coagulans|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Novel Low Cost Bubble CPAP as an Alternative Respiratory Support in Low Resource Setting
Status: COMPLETED
Conditions: Premature|Respiratory Distress Syndrome in Premature Infant
Interventions: DEVICE: Vayu bCPAP|DEVICE: Mechanical Ventilator Driven CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Protein Supplements for Nutritional and Quality of Life Improvement After Pancreatic Resection in Elderly Patients
Status: COMPLETED
Conditions: Pancreatic Cancer|Cholangiocarcinoma|Intraductal Papillary Mucinous Neoplasm|Neuroendocrine Tumor|Solid Pseudopapillary Tumor
Interventions: DIETARY_SUPPLEMENT: oral protein supplements|GENETIC: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Brain Perfusion in Rhythm Control and Rate Control of Persistent Atrial Fibrillation
Status: UNKNOWN
Conditions: Persistent Atrial Fibrillation
Interventions: DRUG: Propafenone|DRUG: Apixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of an Oral Probiotic Tablet on Oral Bacteria and Clinical Measurements (ProBiora3)
Status: UNKNOWN
Conditions: Oral Health
Interventions: OTHER: ProBiora3 mints|OTHER: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Right Ventricle Lipid in Pulmonary Arterial Hypertension (PAH)
Status: RECRUITING
Conditions: Idiopathic Pulmonary Arterial Hypertension|Heritable Pulmonary Arterial Hypertension|Pulmonary Arterial Hypertension Associated With Connective Tissue Disease
Interventions: OTHER: No Intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ZEN-3694, Enzalutamide, and Pembrolizumab for the Treatment of Metastatic Castration-Resistant Prostate Cancer
Status: RECRUITING
Conditions: Castration-Resistant Prostate Carcinoma|Metastatic Prostate Adenocarcinoma|Metastatic Prostate Small Cell Carcinoma|Stage IV Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8|Stage IVB Prostate Cancer AJCC v8
Interventions: DRUG: BET Bromodomain Inhibitor ZEN-3694|DRUG: Enzalutamide|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The EFFECT of NEBULIZED AZITHROMYCIN AS THERAPY for BRONCHOPULMONARY DYSPLASIA
Status: NOT_YET_RECRUITING
Conditions: Bronchopulmonary Dysplasia|Premature|Ventilation, Mechanical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Theta Burst Stimulation and Functional Electrical Stimulation in Stroke Rehabilitation
Status: COMPLETED
Conditions: Strokes Thrombotic
Interventions: PROCEDURE: Theta burst stimulation|PROCEDURE: Functional Electrical Stimulation|PROCEDURE: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking on the Signs and Symptoms of Bullous Keratopathy
Status: COMPLETED
Conditions: Bullous Keratopathy
Interventions: RADIATION: ultraviolet-A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Etanercept for Idiopathic Pneumonia Syndrome Following Stem Cell Transplantation (BMT CTN 0403)
Status: COMPLETED
Conditions: Pneumonia|Idiopathic Pneumonia Syndrome
Interventions: DRUG: Etanercept|DRUG: Placebo plus corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Education Program to Manage Emotional Stress of Stem Cell Transplant Recipients and Their Caregivers
Status: COMPLETED
Conditions: Family Caregivers|Bone Marrow Transplantation
Interventions: BEHAVIORAL: Problem-Solving Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: 0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Critically Ill Children
Status: COMPLETED
Conditions: Hyponatremia
Interventions: DRUG: hypotonic|DRUG: isotonic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alternative Antibiotics for Syphilis
Status: RECRUITING
Conditions: Early Latent Syphilis|Primary Syphilis|Secondary Syphilis
Interventions: DRUG: Linezolid 600 mg|DRUG: Benzathine Penicilllin G
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TIRCON International NBIA Registry
Status: RECRUITING
Conditions: Neurodegeneration With Brain Iron Accumulation (NBIA)|Pantothenate Kinase-associated Neurodegeneration (PKAN)|Beta-Propeller Protein-Associated Neurodegeneration (BPAN)|Mitochondrial Membrane Protein Associated Neurodegeneration (MPAN)|Fatty Acid Hydroxylase-associated Neurodegeneration (FAHN)|Kufor Rakeb Syndrome|Neuroferritinopathy|Aceruloplasminemia|Woodhouse Sakati Syndrome|COASY Protein-associated Neurodegeneration (CoPAN)|PLA2G6-Associated Neurodegeneration (PLAN)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Dexmedetomidine in the Management of Pain After Uterine Artery Embolization
Status: COMPLETED
Conditions: Pain Control
Interventions: DRUG: Dexmedetomidine|DRUG: Normal saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Aronia Berry Consumption on Blood Pressure
Status: COMPLETED
Conditions: Prehypertension|Healthy
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Aronia extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reference Values of Intraepidermal Nerve Fiber Density in Children and Small Fiber Neuropathy in Neurometabolic and Neurodevelopmental Disorders in Children
Status: RECRUITING
Conditions: Mitochondrial Diseases|Developmental Delay Disorder|Small Fiber Neuropathy|Cerebral Palsy
Interventions: DIAGNOSTIC_TEST: Skin biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Custom-made Versus Prefabricated Zirconia Crowns for Primary Molars.
Status: COMPLETED
Conditions: Decayed Teeth
Interventions: OTHER: Custom-made zirconia crowns|OTHER: Prefabricated zirconia crowns
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Learn About the Amount of the Study Medicine (Sisunatovir) in Blood and Its Safety in Infants and Children With Pneumonia Caused by RSV
Status: RECRUITING
Conditions: Respiratory Syncytial Virus Infections
Interventions: DRUG: Placebo|DRUG: Active
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Vitamin D to Slow Progression of Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DIETARY_SUPPLEMENT: Vitamin D (cholecalciferol)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biofeedback Based Virtual Reality Intervention to Manage Postoperative Pain
Status: ENROLLING_BY_INVITATION
Conditions: Pain|Pain, Postoperative|Pain, Acute|Surgery
Interventions: DEVICE: Technology Based Intervention Group 1|DEVICE: Technology Based Intervention Group 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: GTN Therapy on Biomarkers of Immune Escape in Men With Biochemical Recurrence of Prostate Cancer After Primary Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: OTHER: Low Dose GTN 0.0285 mg/hr|OTHER: High Dose GTN 0.057 mg/hr|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Hyperbaric Bupivacaine and Hyperbaric Levobupivacaine in C/S
Status: COMPLETED
Conditions: Health Care|Drugs
Interventions: DRUG: Hyperbaric levobupivacaine|DRUG: Hyperbaric bupivacaine % 0.5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retentive Capacity of Bonded Retainer Vs Vacuum-formed and Combined Bonded-vacuum Retainers
Status: RECRUITING
Conditions: Orthodontic Retainer|Fixed Orthodontic Retainer|Orthodontic Relapse|Essix Retainer|Vacuum-formed Retainer|Dual Retention Protocol
Interventions: DEVICE: Vacuum-formed retainer|DEVICE: Combined Vacuum-formed and Lingual bonded retainer from canine-to-canine.|DEVICE: Lingual bonded retainer from canine-to-canine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Of PF-05212384 Plus Irinotecan Vs Cetuximab Plus Irinotecan In Patients With KRAS And NRAS Wild Type Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: PF-05212384|DRUG: irinotecan|DRUG: Cetuximab|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebellar Transcranial Direct Current Stimulation and Aphasia Treatment
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Anodal or Cathodal tDCS|DEVICE: Sham|BEHAVIORAL: Computerized naming therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Outcome of Pulpotomy Using Biodentine and Portland Cement in Mature Cases With Irreversible Pulpitis: Randomized Clinical Trial
Status: UNKNOWN
Conditions: Irreversible Pulpitis
Interventions: PROCEDURE: Pulpotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Habitual Abortion Study: Oral Dydrogesterone Treatment During Pregnancy in Women With Recurrent Miscarriage
Status: COMPLETED
Conditions: Recurrent Miscarriage
Interventions: DRUG: Dydrogesterone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CHOICE Plus Program: Supporting Relationship-centred Mealtimes for Long-term Care
Status: COMPLETED
Conditions: Dementia|Long-term Care
Interventions: OTHER: CHOICE+ Training Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Moderate to Severe Lateral Canthal Lines and Glabellar Lines Alone or in Combination
Status: COMPLETED
Conditions: Glabellar Frown Lines (GL)|Lateral Canthal Lines (LCL)
Interventions: BIOLOGICAL: botulinum toxin neuromodulator|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT