pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: OFDI Capsule Imaging in Patients With Atrial Fibrillation Undergone Radio Frequency (RF) Ablation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: OFDI Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effectiveness of eHealth on the Self-management of Health Status and QOL Among CAD Patients
Status: COMPLETED
Conditions: eHealth|Coronary Artery Disease|Quality of Life|Self-management
Interventions: COMBINATION_PRODUCT: eHealth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Kisspeptin Administration Subcutaneously to Patients With Reproductive Disorders
Status: RECRUITING
Conditions: Hypothalamic Amenorrhea|Hypogonadotropic Hypogonadism
Interventions: DRUG: Kisspeptin 112-121
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cognitive Process-based Real-time fMRI Neurofeedback in MDD and Rumination
Status: COMPLETED
Conditions: Depression|Anxiety
Interventions: BEHAVIORAL: Active neurofeedback|BEHAVIORAL: Sham neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Cupping Massage in Patients With Chronic Neck Pain - A Randomized Controlled Trial
Status: COMPLETED
Conditions: Neck Pain|Mechanical/Motor Problems With Neck and Trunk
Interventions: PROCEDURE: Cupping massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expiratory Muscle Strength Training for Hypernasal Speech in Children
Status: NOT_YET_RECRUITING
Conditions: Velopharyngeal Insufficiency|Velopharyngeal Incompetence Due to Cleft Palate|Inadequate Velopharyngeal Closure|Palatopharyngeal Incompetence|Hypernasality
Interventions: DEVICE: Expiratory Muscle Strength Training|DEVICE: Maintenance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Years Maintenance of Structured Group Self-management Education in Type 2 Diabetes : a Randomized Controlled Trial
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Structured self-management group education during 2 years
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Durvalumab With or Without Tremelimumab in Resectable Locally Advanced Squamous Cell Carcinoma of the Oral Cavity
Status: ACTIVE_NOT_RECRUITING
Conditions: Oral Cavity Squamous Cell Carcinoma
Interventions: DRUG: Durvalumab|COMBINATION_PRODUCT: Durvalumab + Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sayed Issa's Hybrid Shoulder Arthroscopic-Open Surgical Management (HSSM)
Status: COMPLETED
Conditions: Shoulder Impingement Syndrome|Adhesive Capsulitis|Rotator Cuff Tear|Hill-Sachs Lesion|Frozen Shoulder|Tendinopathy
Interventions: PROCEDURE: Sayed Issa's Hybrid Shoulder Arthroscopic-Open Surgical Management
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Focal Brachytherapy Using Cesium-131 For Patients With Low Risk Prostate Cancer
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: RADIATION: Focal prostate brachytherapy with Cesium-131
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Adductor-Canal-Block (ACB) in Patients After Anterior Cruciate Ligament (ACL) Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Reconstruction
Interventions: PROCEDURE: Ropivacain|PROCEDURE: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Secukinumab for the Inflammatory Phase of Pyoderma Gangrenosum
Status: WITHDRAWN
Conditions: Pyoderma Gangrenosum
Interventions: DRUG: secukinumab 150 mg (2 injections per dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Distal Protection Device in Patients at High Risk for Distal Embolism in Acute Coronary Syndrome (ACS)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Filtrap™ + Thrombus aspiration catheter|PROCEDURE: Thrombus aspiration catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Inspiratory Pause on Ventilatory Efficiency in Robotic Surgery. A Prospective Paired Study.
Status: COMPLETED
Conditions: Mechanical Ventilation|Positive End-Expiratory Pressure|Anesthesia
Interventions: PROCEDURE: Modifying EIP under a tOLA before pneumoperitoneum|PROCEDURE: Modifying EIP under a tOLA with pneumoperitoneum|PROCEDURE: Atelectasis test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REstoring Mental Health After SARS-CoV-2 Through commUnity-based Psychological Services in New York City
Status: RECRUITING
Conditions: Depression|Anxiety|Psychological Distress|PTSD
Interventions: BEHAVIORAL: Problem Management Plus|BEHAVIORAL: Services as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Finding Study for Pain Relief of a Broken Hip
Status: UNKNOWN
Conditions: Femoral Neck Fractures
Interventions: DRUG: Levobupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Implementation of Nutritional Guidelines and Effects in Nursing Home Residents
Status: COMPLETED
Conditions: Implementation Strategies|Nutritional Outcome of Nursing Home Residents
Interventions: OTHER: A one year multifaceted implementation strategy|OTHER: A three hour lecture about the guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: S-1 IMRT Versus S-1 and Cisplatin Concurrent IMRT in Inoperable Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: OTHER: S-1 concurrent radiotherapy|OTHER: S-1 plus Cisplatin concurrent radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Efficacy and Safety of Pitolisant in the Treatment of EDS in Patients With OSA
Status: COMPLETED
Conditions: Excessive Daytime Sleepiness
Interventions: DRUG: Pitolisant|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Research on the Relation of Blood Drug Concentration and Calcium Folinate Rescued in High-dose MTX Therapy
Status: UNKNOWN
Conditions: Osteosarcoma
Interventions: DRUG: Methotrexate,Calcium folinate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Scaling up Mass Testing, Treatment and Tracking on Malaria Prevalence Among Children
Status: COMPLETED
Conditions: Malaria|Malaria, Asymptomatic Parasitaemia
Interventions: COMBINATION_PRODUCT: Artemisinin Combination Therapy ACTs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Iodine-125 Seed Implantation Therapy for Locally Advanced Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: PROCEDURE: 3D-printed non-coplanar template|PROCEDURE: 3D-printed coplanar template
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Safinamide (50 and 100mg/Day) Versus Placebo, in Patients With Mid-late Stage Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Safinamide|DRUG: Safinamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Partial Posterior Hyaloidectomy in Macular Surgery
Status: COMPLETED
Conditions: Retinal Break|Retinal Detachment
Interventions: PROCEDURE: Partial posterior hyaloidectomy (a modified procedure of vitrectomy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Coupling Negative Pressure Wound Therapy With Instillation
Status: RECRUITING
Conditions: Wound|Ulcer|Burns
Interventions: DEVICE: Negative pressure wound therapy coupled with instillation|DEVICE: Standard Negative Pressure Wound Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incentive Spirometry and Upper Abdominal Laparoscopic Surgery
Status: COMPLETED
Conditions: Cholecystitis|Perforated Duodenal Ulcer|Diaphragmatic Hernia|Benign Pancreas Tumor|Malignant Pancreatic Neoplasm|Splenic Infarction|Splenomegaly|Choledocholithiasis|Hiatal Hernia
Interventions: OTHER: Volume-oriented incentive spirometry|OTHER: Flow-oriented incentive spirometry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacological Enhancement for Nocturnal Incontinence in Orthotopic Bladder Substitute
Status: COMPLETED
Conditions: Incontinence|Urinary Incontinence|Urinary Bladder Cancer
Interventions: DRUG: mebeverine 200 mg sustained-release (Coloverine® SR, Chemipharm pharmaceutical, Egypt) one time/day at the evening.|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Abicipar Pegol Intravitreal Injections in Patients With Neovascular AMD
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: Abicipar pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison Study of the Efficacy of Quetiapine and Haloperidol in Agitated Adults in Emergency Room
Status: COMPLETED
Conditions: Agitation
Interventions: DRUG: Quetiapine|DRUG: Haloperidol|DRUG: Lorazepam|DRUG: Cogentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Investigate Hyperglycemic and Hypoglycemic Excursions in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus With Hypoglycemia
Interventions: DRUG: Glucagon|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effective Aids Treatment and Support in the Free State (FEATS)
Status: UNKNOWN
Conditions: HIV/AIDS|Food Insecurity|HIV Infections
Interventions: BEHAVIORAL: ARV peer adherence support (PAS)|DIETARY_SUPPLEMENT: Nutritional support|DRUG: ARV treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Dulaglutide in Combination Therapy Diabetes Mellitus Type 2 Patients With Metformin
Status: RECRUITING
Conditions: Type2 Diabetes Mellitus
Interventions: DRUG: Exendin-4 Fc fusion protein injection(1.2mg）|DRUG: Exendin-4 Fc fusion protein injection（2.4mg）|DRUG: Dulaglutide|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palbociclib in Combination With Tamoxifen as First Line Therapy for Metastatic Hormone Receptor Positive Breast Cancer
Status: COMPLETED
Conditions: Hormone Receptor Positive Malignant Neoplasm of Breast|Human Epidermal Growth Factor 2 Negative Carcinoma of Breast|Estrogen Receptor Positive Breast Cancer|Progesterone Receptor Positive Tumor|Metastatic Breast Cancer
Interventions: DRUG: Palbociclib|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Assessment of Difficult Laryngoscopy Using Different Videolaryngoscopes
Status: COMPLETED
Conditions: Assessment|Difficult Airway Intubation|Preoperative
Interventions: DEVICE: airtraq|DEVICE: mcgrath mac x-blade|DEVICE: storz c-mac|DEVICE: storz d-blade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Cocoa Procyanidins on Vascular Function
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Flavanol and procyanidin supplement|DIETARY_SUPPLEMENT: Procyanidin-containing supplement|DIETARY_SUPPLEMENT: control supplement deprived of flavanols and procyanidins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Investigating the Acute Effects of Blueberry (Poly)Phenols on Vascular Function and Cognition in Healthy Individuals.
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Wild Blueberry Powder|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cardiac Metabolic Remodeling After Pulmonary Vasodilator Therapy in Pulmonary Arterial Hypertension: A Pilot Study
Status: TERMINATED
Conditions: Pulmonary Arterial Hypertension|Right-Sided Heart Failure
Interventions: OTHER: PET/MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Direct Comparison of Cardiac CT With TEE to Evaluate Watchman FLX LAA Occluder Device Characteristics
Status: NOT_YET_RECRUITING
Conditions: Device Related Thrombosis|Peri-device Leak
Interventions: PROCEDURE: Transesophageal echocardiography (TEE)|PROCEDURE: Cardiac CTA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase II Study of Pemetrexed and Carboplatin in the Treatment of Esophageal Cancer
Status: TERMINATED
Conditions: Esophageal Neoplasms
Interventions: DRUG: Pemetrexed|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bronchiolitis All-study, SE-Norway
Status: UNKNOWN
Conditions: Bronchiolitis
Interventions: DRUG: Racemic adrenaline|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy in R/R Acute B Lymphoblastic Leukemia
Status: WITHDRAWN
Conditions: Refractory B Acute Lymphoblastic Leukemia|Relapse B Acute Lymphoblastic Leukemia
Interventions: DRUG: Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multiple Dose Trial Investigating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NNC0123-0000-0338 in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin 338 (GIPET I)|DRUG: placebo|DRUG: insulin glargine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Study of the Serological Response Against the Severe Acute Respiratory Syndrome (SARS) Coronavirus 2 (CoV-2) Virus in 2 Types of Employees, Hospital and Non-hospital, at Institute Curie and Institute Pasteur
Status: COMPLETED
Conditions: Volunteers From the Institute Curie and Institute Pasteur Staff Who Are Not Showing Active SARS-CoV-2 Infection
Interventions: DIAGNOSTIC_TEST: Blood samples (collection of 5 mL of blood in a dry tube)|DIAGNOSTIC_TEST: Nasopharyngeal swabs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of the Safety & PK of INX-08189 in Chronically-infected HCV, Treatment-naïve Subjects
Status: COMPLETED
Conditions: HCV (Genotype 1)
Interventions: DRUG: INX-08189|DRUG: INX-08189|DRUG: INX-08189|DRUG: INX-08189|DRUG: INX-08189|DRUG: INX-08189|DRUG: INX-08189|DRUG: Placebo matching with INX-08189|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Furosemide Use to Fill the Bladder of Pediatric Females Awaiting Pelvic Ultrasound
Status: COMPLETED
Conditions: Ovarian Torsion
Interventions: DRUG: Furosemide|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Randomised Controlled Trial on Using Active Warming to Prevent Newborn Hypothermia After Caesarean Delivery
Status: RECRUITING
Conditions: Newborn; Hyperthermia
Interventions: DEVICE: TechTrade Ready Heat Half Body Temperature Management Blankets|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing TIVA Using Propofol or Dexmedetomidine Versus Sevoflurane During Anaesthesia of Children Undergoing Bone-Marrow Aspiration
Status: COMPLETED
Conditions: Invasive Cancer|Pediatric Cancer
Interventions: DRUG: Sevoflurane|DRUG: Propofol infusion for maintance|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of Abemaciclib (LY2835219) With and Without Food in Participants With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Metabolically Armed CD19 CAR-T Cells (Meta10-19) in the Treatment of r/r DLBCL Clinical Research
Status: RECRUITING
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: Metabolically Armed CD19 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Circadin® in the Treatment of Sleep Disturbances in Children With Neurodevelopment Disabilities
Status: COMPLETED
Conditions: Sleep Disorders
Interventions: DRUG: Circadin 2/5/10 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Implant Fixation in Reverse Total Shoulder Arthroplasty
Status: UNKNOWN
Conditions: Arthritis
Interventions: PROCEDURE: surgery|DEVICE: 0.8 mm diameter Tantalum marker beads
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Weekly Antepartum Testing in Women With BMI 30-40 and Neonatal Outcomes
Status: TERMINATED
Conditions: Obesity Complicating Childbirth
Interventions: OTHER: Ultrasound Examination|OTHER: Antenatal Testing (biophysical profile)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Brexucabtagene Autoleucel in Adults With Rare B-cell Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed/Refractory Waldenstrom Macroglobulinemia|Relapsed/Refractory Richter Transformation|Relapsed/Refractory Burkitt Lymphoma|Relapsed/Refractory Hairy Cell Leukemia
Interventions: BIOLOGICAL: Brexucabtagene Autoleucel|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine and Compare the Tolerance and Irritation Potential of Topical Acne Medications
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: clindamycin and benzoyl peroxide|DRUG: Dapsone gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Titanium Versus Soft Metal CAD/CAM Frameworks for All-on-4 Implant Supported Prosthesis
Status: RECRUITING
Conditions: Dental Prosthesis
Interventions: OTHER: CADCAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaginal Estrogen With Pessary Treatment
Status: COMPLETED
Conditions: Vaginal Infection|Urinary Tract Infection|Quality of Life
Interventions: DRUG: Premarin vaginal cream|DRUG: Placebo cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A 12 Week Study of QVA149 Compared to Fluticasone/Salmeterol (Advair) for Treatment of COPD
Status: WITHDRAWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: QVA149|DRUG: fluticasone/salmeterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Drug-drug Interaction Study Evaluating the PK Effects of Obicetrapib on Atorvastatin and Rosuvastatin
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Obicetrapib|DRUG: Atorvastatin Calcium|DRUG: Rosuvastatin Calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3841136 in Overweight and Obese Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Overweight
Interventions: DRUG: Tirzepatide|DRUG: LY3841136|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness Allopurinol Topical Agent Prevention Capecitabine-induced Hand-foot Syndrome
Status: COMPLETED
Conditions: Hand-foot Syndrome
Interventions: DRUG: Allopurinol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Research Study to Bank Samples for Future Evaluation to Identify Biomarkers That Predispose Crohn's Disease and Ulcerative Colitis Patients to Develop Hepatosplenic T-Cell Lymphoma (HSTCL)
Status: COMPLETED
Conditions: Hepatosplenic T-Cell Lymphoma
Interventions: DRUG: Infliximab|DRUG: Golimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Tolerability and Efficacy of INSTYLAN in Subjects With Moderate to Severe Hemorrhagic Cystitis
Status: UNKNOWN
Conditions: Hemorrhagic Cystitis
Interventions: DEVICE: INSTYLAN (Sodium Hyaluronate 80mg/50ml)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arsenic Trioxide and Etanercept in Treating Patients With Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases
Interventions: BIOLOGICAL: etanercept|DRUG: arsenic trioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Dual Epicardial Endocardial Persistent Atrial Fibrillation (AF) Study
Status: COMPLETED
Conditions: Persistent Atrial Fibrillation|Longstanding Persistent Atrial Fibrillation
Interventions: DEVICE: Hybrid: AtriCure Bipolar System & EP ablation procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy Plus Chemotherapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: fluorouracil|DRUG: irinotecan hydrochloride|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: P. Falciparum Resistance to Artemisinin in Vietnam
Status: UNKNOWN
Conditions: Drug Resistant Malaria Due to Plasmodium Falciparum
Interventions: DRUG: Artesunate (AS) group|DRUG: DHA - PPQ group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peritoneal Lavage on the Incidence of Pancreatic Fistula and Related Complications After Pancreatoduodenectomy
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Fistula|Pancreaticoduodenal; Fistula
Interventions: PROCEDURE: Peritoneal lavage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Measuring Relative Afferent Pupillary Defect
Status: ACTIVE_NOT_RECRUITING
Conditions: Relative Afferent Pupil Defect (RAPD)
Interventions: DIAGNOSTIC_TEST: Swinging Light test|DIAGNOSTIC_TEST: Virtual Reality Head-Mounted Display (VR HMD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Genomic Biomarker-Selected Umbrella Neoadjuvant Study for High Risk Localized Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Apalutamide 60mg Tab|DRUG: Abiraterone Acetate 250mg|DRUG: Prednisone 5mg Tab|DRUG: Docetaxel|DRUG: Niraparib 100mg Oral Capsule|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perform Necrotic Cavity Lavage or Not After Debridement of Infected Pancreatic Necrosis
Status: UNKNOWN
Conditions: Pancreatitis,Acute Necrotizing|Pancreas Necrosis
Interventions: PROCEDURE: necrotic cavity lavage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Combined Treatment With Uric Acid and rtPA in Acute Ischemic Stroke
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Uric Acid|OTHER: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interventional Study to Assess Efficacy and Safety of Velmanase Alfa in Patients With Alpha Mannosidosis
Status: WITHDRAWN
Conditions: Alpha-Mannosidosis
Interventions: DRUG: Velmanase Alfa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cell Therapy in Critical Limb Ischemia
Status: UNKNOWN
Conditions: Critical Limb Ischemia
Interventions: BIOLOGICAL: allogeneic umbilical cord-derived mesenchymal stem cells|BIOLOGICAL: Placebo (NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of Capecitabine Tablets 500 mg in Adult Cancer Patients Under Fed Condition
Status: UNKNOWN
Conditions: Colon Cancer|Breast Cancer
Interventions: DRUG: Capecitabine|DRUG: XELODA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin in Combined With Cisplatin Plus Paclitaxel With Advanced Esophageal Squamous Cell Carcinoma (ECMTPneo)
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: metformin and chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KU Alternate Meal Energy Level Study
Status: COMPLETED
Conditions: Obesity|Weight Loss
Interventions: DIETARY_SUPPLEMENT: Portion-Controlled Meals|BEHAVIORAL: Low-Calorie Diet|BEHAVIORAL: Intermittent Very-Low Calorie Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intralymphatic Immunotherapy (ILIT) for House Dust Mite, Cat, and Dog Allergen in Allergic Rhinitis Patients
Status: TERMINATED
Conditions: Allergic Rhinitis
Interventions: DRUG: HollisterStier|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Extracorporeal Shockwave Therapy in the Treatment of Patients With Resistant Hypertension
Status: UNKNOWN
Conditions: Hypertension, Resistant to Conventional Therapy
Interventions: DEVICE: Omnispec model Vascuspec
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Gymnema Sylvestre on Patients With Impaired Glucose Tolerance.
Status: COMPLETED
Conditions: Impaired Glucose Tolerance
Interventions: DRUG: Gymnema Sylvestre|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Recombinant Versus Urinary hCG for Ovulation Induction in High Responders
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: rHCG 250ug|DRUG: uHCG 5000 IU|DRUG: uHCG 7500 IU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A SMART Design to Optimize the Delivery of TEMPO for Men With Prostate Cancer and Their Caregivers
Status: NOT_YET_RECRUITING
Conditions: Cancer of the Prostate|Anxiety
Interventions: BEHAVIORAL: TEMPO|OTHER: Active Monitoring dyads' anxiety
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 1 Study of SAIL66 in Patients With CLDN6-positive Locally Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: SAIL66
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of Lapatinib Versus Placebo Followed By Chemoradiation In Patients With Locally Advanced Head And Neck Cancer
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of Head and Neck
Interventions: DRUG: Lapatinib oral tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Liposomal Mitoxantrone Hydrochloride Injection Combined With Pegaspargase in the Treatment of NKTCL
Status: TERMINATED
Conditions: Extranodal NK/T-cell Lymphoma, Nasal Type
Interventions: DRUG: Part 1: Liposomal mitoxantrone hydrochloride and Pegaspargase|DRUG: Part 2 (treatment-naïve patients): Liposomal mitoxantrone hydrochloride and Pegaspargase|DRUG: Part 2 (relapsed or refractory patients): Liposomal mitoxantrone hydrochloride and Pegaspargase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled RSA Study Comparing the Taperloc Complete Versus the Taperloc Complete Microplasty.
Status: COMPLETED
Conditions: Hip Osteoarthritis|Noninflammatory Degenerative Joint Disease|Avascular Necrosis|Correction of Functional Deformity|Rheumatoid Arthritis
Interventions: DEVICE: Taperloc Complete Microplasty stem|DEVICE: Taperloc Complete Reduced Distal stem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Guselkumab (Anti-IL 23 Monoclonal Antibody) for Alcohol Associated Liver Disease
Status: COMPLETED
Conditions: Alcoholic Liver Disease
Interventions: DRUG: Guselkumab 30mg|DRUG: Guselkumab 70mg|DRUG: Guselkumab 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CNI-1493 for Treatment of Moderate to Severe Crohn's Disease
Status: TERMINATED
Conditions: Crohn Disease
Interventions: DRUG: semapimod|DRUG: semapimod|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy of Recurrent Cervical Cancers Using Dendritic Cells (DCs)
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: BIOLOGICAL: HPV16 E7 peptide-pulsed autologous DCs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Cannabis Use in People With Schizophrenia on Clinical, Neuropsychological and Physiological Phenotypes
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: Dronabinol|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: APL-501 Study for Select Advanced or Relapsed/Recurrent Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor|Microsatellite Instability|Mismatch Repair Deficiency|Cancer of Unknown Primary Site
Interventions: DRUG: APL-501
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robotic Endoscopic Neurosurgical Interventions
Status: NOT_YET_RECRUITING
Conditions: Robot for Endoscopic Neurosurgical Interventions
Interventions: DEVICE: Robotic endoscopic neurosurgical intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Drugs for High Blood Pressure and High Cholesterol in American Indians With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetic Nephropathy
Interventions: DRUG: Lisinopril|DRUG: Nifedipine|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Open-Label, Single-Center Study to Evaluate the Exposure-Response Relationship Between the Plasma Drug Concentrations and the Change From Baseline in QTc at Steady State Following Once-daily Administration of CASSIPA® in Opioid Dependent Subjects.
Status: WITHDRAWN
Conditions: Evaluation of QTc Interval
Interventions: COMBINATION_PRODUCT: 16 mg buprenorphine with 4 mg naloxone sublingual film
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Sorafenib and Paclitaxel in Treating Patients With Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: paclitaxel|DRUG: sorafenib tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Children and Adolescents With Refractory or Relapsed Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Fludarabine, Cytarabine, Liposomal daunorubicin (DaunoXome)|DRUG: Etoposide, Thioguanine, Cyclophosphamide, Busulfan, Melphalan|PROCEDURE: Hematopoietic stem cell transplant|RADIATION: Total body irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Nebulised Gentamicin in Patients With Bronchiectasis
Status: COMPLETED
Conditions: Bronchiectasis
Interventions: DRUG: Gentamicin|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carbohydrate Beta Cell Function and Glucose Control in Children With Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1
Interventions: OTHER: Ketogenic diet, food delivery and education|OTHER: Standard diet, food delivery and education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: sFlt1/PlGF and Planned Delivery to Prevent Preeclampsia at Term.
Status: RECRUITING
Conditions: Preeclampsia|Intrauterine Growth Restriction|Maternal Hypertension|Neonatal Outcome|Perinatal Death
Interventions: DIAGNOSTIC_TEST: sFlt1/PlGF screening in maternal blood at 35 to 36.6 weeks of gestation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: the Efficacy and Safety of Diosmin in Patients With Ulcerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: Placebo|DRUG: Diosmin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Bezafibrate on Cholestatic Itch
Status: UNKNOWN
Conditions: Primary Biliary Cholangitis|Primary Sclerosing Cholangitis|Secondary Sclerosing Cholangitis
Interventions: DRUG: Bezafibrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: North American Study for the Treatment of Refractory Ascites (NASTRA)
Status: COMPLETED
Conditions: Ascites|Liver Cirrhosis
Interventions: PROCEDURE: Transjugular intrahepatic portasystemic shunts (TIPS)|PROCEDURE: Total paracentecis (TP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Autologous T-Cell Transplantation With Vaccine Driven Expansion of Anti-Tumor Effectors After Cytoreductive Therapy in Metastatic Pediatric Sarcomas
Status: COMPLETED
Conditions: Ewing's Sarcoma|Rhabdomyosarcoma
Interventions: BIOLOGICAL: therapeutic autologous dendritic cells|DRUG: indinavir sulfate|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endometrial Polypectomy Performed With Bipolar Electrode Versapoint vs Microscissors or Graspers
Status: UNKNOWN
Conditions: Endometrial Polyps
Interventions: PROCEDURE: Bipolar Polypectomy|PROCEDURE: Mechanical Polypectomy|DEVICE: Bipolar electrode|DEVICE: Microscissors or graspers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regeneration of Human Intrabony Defects With rhFGF-2/HA
Status: COMPLETED
Conditions: Periodontitis
Interventions: DEVICE: a gel containing 4mg/ml rhFGF-2 in sodium hyaluronate|PROCEDURE: Periodontal flap surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetes, Falls, and Fractures
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathy|Diabetes|Balance; Distorted|Vestibular Neuropathy|Muscle Weakness|Sarcopenia|Autonomic Neuropathy, Diabetic|Small Fiber Neuropathy
Interventions: DIAGNOSTIC_TEST: Quantative Sensory Testing|DIAGNOSTIC_TEST: NCStat-DPN-Check|DIAGNOSTIC_TEST: Composite Autonomic Symptom Score 31|DIAGNOSTIC_TEST: Computerized dynamic posturography|DIAGNOSTIC_TEST: Video Head Impulse Test|DIAGNOSTIC_TEST: Accelerometer|DIAGNOSTIC_TEST: Handgrip strength|DIAGNOSTIC_TEST: Dual Energy X-ray Absorbtimetry scan|DIAGNOSTIC_TEST: Force Plate Platform
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy Study to Treat Subjects With Severe Hypertriglyceridemia
Status: UNKNOWN
Conditions: Severe Hypertriglyceridemia
Interventions: DRUG: AKR-963
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeting Hypervigilance and Autonomic Arousal: the Psycho-physiologic Model of Gastroesophageal Reflux Disease (GERD)
Status: ENROLLING_BY_INVITATION
Conditions: Gastroesophageal Reflux
Interventions: OTHER: Cognitive Behavioral Therapy|OTHER: Sham-SOC Lifestyle Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Probiotics (L. Reuteri ATCC PTA 5289 and L. Reuteri DSM 17938) on Symptoms of Viral Upper Respiratory Tract Infections in Children
Status: RECRUITING
Conditions: Virus Diseases in Children
Interventions: DIETARY_SUPPLEMENT: BioGaia Pharax (L. reuteri PTA 5289 and DSM 17938)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Peripheral Venous Pressure as an Indicator of Central Venous Pressure in Post Operative Surgical Patients: A Randomised Controlled Trial
Status: COMPLETED
Conditions: Peripherial Venous Pressure|Central Venous Pressure|Fluid/Volume Status Monitoring of Patient
Interventions: PROCEDURE: Peripherial and central venous access
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Scar Outcomes for Scalpel Versus Diathermy Neck Incisions in an Afro-Caribbean Population
Status: COMPLETED
Conditions: Surgical Incision
Interventions: PROCEDURE: Surgical incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Soi TS3 Surface in Patients With and Without Type 2 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Dental Implant|Dental Implant-Abutment Design
Interventions: DEVICE: Implant placement with soi surface in diabetic subjects|DEVICE: Implant placement with soi surface in healthy subjects
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone Plus Virtual Reality Exposure Therapy for PTSD
Status: COMPLETED
Conditions: PTSD
Interventions: BEHAVIORAL: Virtual reality exposure therapy|DRUG: 0.5 mg DEX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FGF-1 for Intramuscular Injection for the Treatment of Peripheral Arterial Disease
Status: UNKNOWN
Conditions: Peripheral Arterial Disease|Stenosis|Intermittent Claudication
Interventions: DRUG: FGF-1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicentre Study on Rapid Versus Slow Withdrawal of Antiepileptic Monotherapy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Rapid withdrawal of antiepileptic|DRUG: Slow withdrawal of antiepileptic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aminolevulinic Acid During Surgery in Treating Patients With Malignant Brain Tumors
Status: TERMINATED
Conditions: Adult Anaplastic Astrocytoma|Adult Anaplastic Oligodendroglioma|Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Adult Mixed Glioma|Recurrent Adult Brain Tumor
Interventions: DRUG: aminolevulinic acid|OTHER: laboratory biomarker analysis|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The CONFIDENCE Registry
Status: UNKNOWN
Conditions: Symptomatic Degenerative Aortic Stenosis|Severe Aortic Stenosis
Interventions: DEVICE: Portico™ Valve, Portico Delivery System(s) and Loading Systems(s)|DEVICE: Portico™ Valve, FlexNav Delivery System(s) and Loading Systems(s)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transarterial Chemoembolization Compared With Stereotactic Body Radiation Therapy or Stereotactic Ablative Radiation Therapy in Treating Patients With Residual or Recurrent Liver Cancer Undergone Initial Transarterial Chemoembolization
Status: TERMINATED
Conditions: Child-Pugh Class A|Child-Pugh Class B|Recurrent Hepatocellular Carcinoma
Interventions: RADIATION: Stereotactic Body Radiation Therapy|PROCEDURE: Transarterial Chemoembolization|DRUG: embolic agent|DRUG: lipiodol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT