pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Leiden Thrombosis Recurrence Risk Prevention
Status: RECRUITING
Conditions: Venous Thromboembolism|Venous Thromboses|Pulmonary Embolism|Deep Vein Thrombosis
Interventions: OTHER: Randomised treatment advice (discontinue vs continue after 3 months)|DIAGNOSTIC_TEST: VTE-BLEED score|DIAGNOSTIC_TEST: L-TRRiP score|OTHER: Advise to continue anticoagulant treatment after 3 months|OTHER: Advise to discontinue anticoagulant treatment after 3 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of the Free Flow Medical Lung Tensioning Device System for the Treatment of Severe Emphysema
Status: COMPLETED
Conditions: Emphysema or COPD
Interventions: DEVICE: FreeFlowMedical Lung Tensioning Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of TTP054 for 12 Weeks in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: TTP054|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Eplerenone in Systemic Right Ventricle
Status: COMPLETED
Conditions: Transposition of Great Vessels|Atrial Switch Procedure
Interventions: DRUG: Eplerenone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Noninvasive Continuous Cardiac Output by the Clearsight® With Invasive Monitoring by PICCO® in Abdominal Major Surgery
Status: COMPLETED
Conditions: Cardiac Output Measurement
Interventions: DEVICE: Cardiac output and stroke ejection volume monitoring with both ClearSight® and PICCO® in major abdominal surgery.
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Effects of Allium Sativum and Moringa Oleifera Extract on Dental Enamel
Status: ACTIVE_NOT_RECRUITING
Conditions: Lead Poisoning
Interventions: OTHER: Lead Acetate|DIETARY_SUPPLEMENT: Moringa oleifera Extract|DIETARY_SUPPLEMENT: Allium sativum Extract|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Imaging Evaluation of PLN-74809 in Participants With IPF (PLN-74809)
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: PLN-74809|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Exenatide for the Treatment of Postprandial Hyperinsulinemic Hypoglycemia
Status: COMPLETED
Conditions: Hyperinsulinemic Hypoglycemia
Interventions: DRUG: Exenatide|DRUG: Acarbose|DRUG: Exenatide Placebo|DRUG: Acarbose Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Develop a High Quality Health Care Delivery Model for the Management of Hypertension and Diabetes at CHCs and District Hospitals of Himachal Pradesh.
Status: COMPLETED
Conditions: Hypertension|Type 2 Diabetes Mellitus
Interventions: OTHER: Evidence based, DSS enabled, health care delivery model
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia
Status: RECRUITING
Conditions: Obstructive Sleep Apnea|Hypertonia, Muscle|Nasal Airway Obstruction|Tolerance|Trisomy 21|Down Syndrome
Interventions: DEVICE: Self-Supporting Nasopharyngeal Airway (ssNPA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors
Status: COMPLETED
Conditions: Childhood Embryonal Tumor|Childhood Extracranial Germ Cell Tumor|Childhood Extragonadal Germ Cell Tumor|Childhood Malignant Ovarian Germ Cell Tumor|Childhood Malignant Testicular Germ Cell Tumor|Childhood Teratoma|Ovarian Embryonal Carcinoma|Ovarian Yolk Sac Tumor|Stage II Malignant Testicular Germ Cell Tumor|Stage IIA Ovarian Germ Cell Tumor|Stage IIB Ovarian Germ Cell Tumor|Stage IIC Ovarian Germ Cell Tumor|Stage III Malignant Testicular Germ Cell Tumor|Stage IIIA Ovarian Germ Cell Tumor|Stage IIIB Ovarian Germ Cell Tumor|Stage IIIC Ovarian Germ Cell Tumor|Testicular Choriocarcinoma and Yolk Sac Tumor|Testicular Embryonal Carcinoma
Interventions: PROCEDURE: conventional surgery|DRUG: cisplatin|DRUG: etoposide|BIOLOGICAL: bleomycin sulfate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Health Care Management and Rehabilitation Skills Training for Treating Serious Mental Illness in Older People
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Bipolar Disorder|Major Depression
Interventions: BEHAVIORAL: Health Care Management and Supported Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: PEDIATRIC SONICS: Pediatric Study of Neuropsychology and Imaging in CNS Demyelinating Syndromes.
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting|Neuromyelitis Optica|Acute Disseminated Encephalomyelitis|Transverse Myelitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MabThera (Rituximab) in Combination With CHOP (or CHOP-like) Chemotherapy in Patients With Aggressive B-Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Lymphoma, Large B-Cell, Diffuse, Non-Hodgkin's Lymphoma, Lymphoma, Non Hodgkin, Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Hydroxydaunorubicin|DRUG: Oncovin|DRUG: Prednisone|DRUG: Rituximab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Identifying and Managing Alcohol-related Health Problems in General Practice
Status: COMPLETED
Conditions: Alcohol-Related Disorders|Alcohol Problem|Alcohol Drug Interaction|Alcohol Use Disorder
Interventions: BEHAVIORAL: 'Change' - an e-health intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Effectiveness Study of the VEGA UV-A System for Cross-linking in Eyes With Keratoconus and Ectasia
Status: TERMINATED
Conditions: Keratoconus and Ectasia
Interventions: DRUG: Riboflavin|DEVICE: VEGA UV-A Illumination System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers
Status: RECRUITING
Conditions: Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Metastatic Head and Neck Squamous Cell Carcinoma|Metastatic Hypopharyngeal Squamous Cell Carcinoma|Metastatic Laryngeal Squamous Cell Carcinoma|Metastatic Lip and Oral Cavity Carcinoma|Metastatic Nasal Cavity Squamous Cell Carcinoma|Metastatic Nasopharyngeal Squamous Cell Carcinoma|Metastatic Pharyngeal Squamous Cell Carcinoma|Metastatic Sinonasal Squamous Cell Carcinoma|Recurrent Head and Neck Squamous Cell Carcinoma|Recurrent Hypopharyngeal Squamous Cell Carcinoma|Recurrent Laryngeal Squamous Cell Carcinoma|Recurrent Lip and Oral Cavity Squamous Cell Carcinoma|Recurrent Nasopharyngeal Squamous Cell Carcinoma|Recurrent Pharyngeal Squamous Cell Carcinoma|Recurrent Sinonasal Squamous Cell Carcinoma|Stage IV Hypopharyngeal Carcinoma AJCC v8|Stage IV Laryngeal Cancer AJCC v8|Stage IV Lip and Oral Cavity Cancer AJCC v8|Stage IV Nasopharyngeal Carcinoma AJCC v8|Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IV Sinonasal Cancer AJCC v8
Interventions: BIOLOGICAL: Atezolizumab|BIOLOGICAL: Bevacizumab|PROCEDURE: Biospecimen Collection|DRUG: Carboplatin|BIOLOGICAL: Cetuximab|DRUG: Cisplatin|PROCEDURE: Computed Tomography|DRUG: Docetaxel|PROCEDURE: Echocardiography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial of the Nutrition-Supported Diabetes Education Program
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Food support|OTHER: Case-management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Carbetocin Versus Ergometrin in the Prevention of Postpartum Hemorrhage
Status: UNKNOWN
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Carbetocin|DRUG: Ergometrine Maleate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Clinical Efficacy and Immunologic Response After IL-2 Therapy in HCV-related Vasculitis Patients
Status: COMPLETED
Conditions: Cryoglobulinemia Vasculitis
Interventions: DRUG: Proleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Intubation Duration Between Rapid Sequence Intubation (RSI) Technique and Non-RSI Technique
Status: COMPLETED
Conditions: Tracheal Intubation Morbidity
Interventions: DRUG: RSI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effects of Mometasone Furoate/Formoterol Combination Versus Mometasone Furoate Alone in Persistent Asthmatics (Study P04073AM1)(COMPLETED)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Mometasone Furoate/Formoterol Fumarate Combination MDI 100/10 mcg BID|DRUG: Mometasone Furoate MDI (MF MDI)|DRUG: Formoterol Fumarate 10 mcg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Protein Metabolism in Newly Diagnosed Pediatric Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Crohn's Disease|Ulcerative Colitis|Protein Metabolism
Interventions: OTHER: stable isotope infusions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Selection Criteria in Endovascular Thrombectomy and Thrombolytic Therapy (SECRET) Study: Development of Patient Selection Criteria Using CT Images and Accompanying Diseases for Efficient Intravenous Thrombolytic and Intra-arterial Recanalization Therapy in Acute Ischemic Stroke
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: OTHER: Brain CT imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Talimogene Laherparepvec and Panitumumab for the Treatment of Locally Advanced or Metastatic Squamous Cell Carcinoma of the Skin
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Skin Squamous Cell Carcinoma|Metastatic Skin Squamous Cell Carcinoma|Recurrent Skin Squamous Cell Carcinoma
Interventions: BIOLOGICAL: Panitumumab|BIOLOGICAL: Talimogene Laherparepvec
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of CG100649 for Primary Osteoarthritis in Male Subjects
Status: UNKNOWN
Conditions: Osteoarthritis, Knee|Osteoarthritis, Hip
Interventions: DRUG: CG100649|DRUG: Silicified microcrystalline cellulose + talc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Expiratory Pressure Modulation in Moderate to Severe COPD Patients - Phase 1b
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Noninvasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Probiotics for Enhanced Tissue Carotenoid Status in Premenopausal Women
Status: COMPLETED
Conditions: Carotenoid Status|Gut Microbiome|Skin Health
Interventions: DIETARY_SUPPLEMENT: Probiotic|OTHER: Placebo|DIETARY_SUPPLEMENT: Carotenoid supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV)
Status: RECRUITING
Conditions: Leptomeningeal Disease|Triple Negative Breast Cancer|HER2-positive Breast Cancer
Interventions: BIOLOGICAL: Dendritic Cell Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Colorectal Cancer Screening Strategies in China
Status: UNKNOWN
Conditions: Colorectal Neoplasms
Interventions: DIAGNOSTIC_TEST: Qualitative Fecal immunochemical test + APCS score|DIAGNOSTIC_TEST: Quantitative Fecal immunochemical test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: A Study of RC48-ADC Combined With JS001 For Perioperative Treatment of Muscle-Invasive Bladder Cancer
Status: RECRUITING
Conditions: Muscle Invasive Bladder Carcinoma
Interventions: DRUG: RC48-ADC|DRUG: JS001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of ACUVUE® OASYS 1-Day for Astigmatism Contact Lenses With Alternative Lidstock
Status: COMPLETED
Conditions: Ocular Physiology
Interventions: DEVICE: Acuvue Oasys 1 Day for Astigmatism with Legacy lidstock|DEVICE: Acuvue Oasys 1 Day for Astigmatism with Amcor laminated lidstock
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of a Powered Knee Orthosis on Gait Kinematics of Children With Knee Extension Deficiency
Status: COMPLETED
Conditions: Cerebral Palsy|Spina Bifida|Spinal Cord Injuries
Interventions: DEVICE: Agilik
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transition From Basal/Bolus to Once-weekly Subcutaneous Semaglutide and Basal Insulin in Patients With T2D
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Semaglutide|DRUG: Insulin Degludec|DRUG: Insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smart Digital Denture Conversion (SDDC), a Technique for Full Arch Immediate Loading
Status: COMPLETED
Conditions: Complete Edentulism
Interventions: PROCEDURE: conventional denture conversion|PROCEDURE: digital denture conversion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of TRANSKRIP ® Plus Chemotherapy in Recurrent-Persistent Cervical Cancer
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: DRUG: Hydralazine/Magnesium|DRUG: Placebo|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Philadelphia Chromosome Positive CML Patients Without Optimal Response or Tolerance to Bcr-Abl TKI
Status: COMPLETED
Conditions: Leukemia|Leukemia, Myeloid|Leukemia, Myelogenous, Chronic, BCR-ABL Positive|Philadelphia Chromosome|Hematologic Diseases
Interventions: DRUG: Radotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of Glufosfamide in Combination With Gemcitabine in Cancer
Status: COMPLETED
Conditions: Neoplasms|Pancreatic Neoplasms
Interventions: DRUG: Glufosfamide|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Haemodynamic and Cardiovascular Effects of Carbetocin and Oxytocin
Status: COMPLETED
Conditions: Pregnancy Related|Anaesthesia
Interventions: DRUG: Carbetocin|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Psilocybin Change Synaptic Density in Amnestic Mild Cognitive Impairment
Status: RECRUITING
Conditions: Amnestic Mild Cognitive Impairment
Interventions: DRUG: Psilocybin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Anti-Tumor Activity of TYRA-200 in Advanced Cholangiocarcinoma With Activating FGFR2 Gene Alterations
Status: RECRUITING
Conditions: Locally Advanced Cholangiocarcinoma|Intrahepatic Cholangiocarcinoma|Solid Tumor|Metastatic Cholangiocarcinoma
Interventions: DRUG: Phase 1 Part A - dose escalation TYRA-200 taken once daily by mouth in 28-day cycles|DRUG: Phase 1 Part B - dose expansion TYRA-200 taken once daily by mouth in 28-day cycles
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abdominal Binders to Treat Orthostatic Hypotension in Parkinsonian Syndromes
Status: RECRUITING
Conditions: Parkinson Disease|Multiple System Atrophy, Parkinson Variant|Orthostatic; Hypotension, Neurogenic
Interventions: DEVICE: Elastic abdominal binder|DEVICE: Placebo binder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Using Perineal Warm Compress Techniques During the Second Stage of Labor on Perineal Outcomes
Status: COMPLETED
Conditions: Heat Therapy|Perineal Tear|Pain|Labor
Interventions: PROCEDURE: Perineal warm compression Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigation Into the Role of GTN & RIPC in Cardiac Surgery
Status: COMPLETED
Conditions: Myocardial Reperfusion Injury
Interventions: OTHER: Remote ischaemic preconditioning|DRUG: IV Normal saline|DRUG: IV Glyceryl trinitrate 2-5ml/h
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Integrated TCM Combined With Chemotherapy in Postoperative NSCLC Patients
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: TCM|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nitrous Oxide and Risk of Cancer Recurrence After Colorectal Surgery: A Randomized, Blinded Study
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: nitrous oxide|DRUG: nitrogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Reduction of Post-operative Endodontic Pain
Status: COMPLETED
Conditions: Post Operative Endodontic Pain
Interventions: DRUG: Lornoxicam|DRUG: normal saline|DRUG: no injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment Study to Evaluate Specific Immune Response in Locally Advanced Cervix Cancer After Radio-chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: Cisplatin injection|COMBINATION_PRODUCT: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing the Effects of Active Surveillance Stress, Uncertainty and Rumination Thru Engagement in Mindfulness Education
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BEHAVIORAL: Health promotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Theta Burst Stimulation on the Brain Response to Drug and Alcohol Cues
Status: COMPLETED
Conditions: Alcoholism|Cocaine Addiction|Drug Addiction
Interventions: DEVICE: Real continuous Theta Burst Stimulation|DEVICE: Sham continuous Theta Burst Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Debio 0932 in Patients With Advanced Solid Tumours or Lymphoma
Status: COMPLETED
Conditions: Cancer|Neoplasms|Solid Tumors|Lymphoma
Interventions: DRUG: Debio 0932
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Trial of Naproxen Sodium/ Diphenhydramine
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Naproxen sodium 440 mg/DPH 50 mg (BAY98-7111)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Evaluation of Chemotherapy Influence on Clinical and Biological Markers of Ovarian Reserve
Status: TERMINATED
Conditions: Infertility
Interventions: OTHER: Biology and ultrasonography after chemotherapy|OTHER: Biology and ultrasonography after chemotherapy|OTHER: Biology and ultrasonography after chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Repeat Injection of Cingal® for Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: COMBINATION_PRODUCT: Cingal|COMBINATION_PRODUCT: Cingal|COMBINATION_PRODUCT: Cingal
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Overground Walking Program With Robotic Exoskeleton in Long-term Manual Wheelchair Users With Spinal Cord Injury
Status: TERMINATED
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Wearable Robotic Exoskeleton for Ambulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Morphological Root Canal Variation in C-shaped Canal Will be Assessed for Age by Using Cone Beam Computed Tomography
Status: UNKNOWN
Conditions: Decayed Teeth
Interventions: OTHER: CBCT data of c-shaped canal in mandibular second molar.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of Efgartigimod in Adult Patients With Primary Immune Thrombocytopenia (ITP)
Status: WITHDRAWN
Conditions: Primary Immune Thrombocytopenia (ITP)
Interventions: BIOLOGICAL: efgartigimod|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine and Capecitabine With or Without T-ChOS as Adjuvant Therapy for Patients With Resected Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DIETARY_SUPPLEMENT: T-ChOS|DRUG: Gemcitabine|DIETARY_SUPPLEMENT: Placebo|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Predictors of Adverse Left Ventricular Remodeling and Final Infarct Size After Primary Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction: A Strain Analysis Study Using Echocardiography and Feature Tracking Cardiac Magnetic Resonance
Status: COMPLETED
Conditions: ST Elevation Myocardial Infarction|Remodeling, Left Ventricle
Interventions: DIAGNOSTIC_TEST: speckle tracking echo
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ministry of Child and Family Development (MCFD) Interpersonal Psychotherapy for Adolescents (IPT-A) Training Project
Status: COMPLETED
Conditions: Education of Therapists Treating Adolescent Depression
Interventions: BEHAVIORAL: Psychotherapy Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Chloroprocaine Spinal for Outpatient Knee Surgery
Status: TERMINATED
Conditions: Knee Arthroscopy
Interventions: DRUG: Chloroprocaine|DRUG: Mepivacaine|DRUG: General Anesthetics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Green Tea Ointment in Treatment of Superficial Skin Cancer
Status: COMPLETED
Conditions: Carcinoma, Basal Cell
Interventions: DRUG: Sinecatechins 10%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of SPL84 in Healthy Volunteers
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: SPL84|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Imiquimod Cream, 3.75% to Zyclara® (Imiquimod) Cream, 3.75% in the Treatment of Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Imiquimod Cream, 3.75%|DRUG: Zyclara®|OTHER: Vehicle of Test Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Laparoscopy-assisted Ovarian Cystectomy: NEW APPROCH
Status: COMPLETED
Conditions: Ovarian Cysts
Interventions: PROCEDURE: laproscopy|PROCEDURE: combined laproscopic and minilaparotomy ovarian cystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Histology Intravascular Ultrasound to Evaluate Prognostic Risks of Saphenous Vein Graft Disease Before Percutaneous Coronary Intervention.
Status: UNKNOWN
Conditions: Major Adverse Cardiovascular Events|Saphenous Vein Graft Disease|Virtual Histology Intravascular Ultrasound|Percutaneous Coronary Intervention
Interventions: DIAGNOSTIC_TEST: virtual histology intravascular ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Relative Bioavailability of Colcrys™ 0.6 mg Tablets in Healthy Young and Elderly Volunteers Under Fasted Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Colcrys™ (colchicine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interruption of Dorsal Visual Stream Using TMS
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: No TMS intervention|DEVICE: TMS over the PO3 EEG site|DEVICE: TMS over the vertex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Effect of Ampreloxetine (TD-9855) for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure
Status: COMPLETED
Conditions: Symptomatic Neurogenic Orthostatic Hypotension
Interventions: DRUG: ampreloxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Volume of Local Anesthetic for Adductor Canal Block on Quadriceps Muscle Function: A Dose Finding Study
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Ropivacaine 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Long Term Safety of Naldemedine
Status: COMPLETED
Conditions: Opioid-induced Constipation
Interventions: DRUG: Naldemedine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 (OV935) as an Adjunctive Therapy in Pediatric Participants With Developmental and/or Epileptic Encephalopathies
Status: COMPLETED
Conditions: Epilepsy|Dravet Syndrome|Lennox-Gastaut Syndrome
Interventions: DRUG: TAK-935|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nutritional Counseling vs. Nutritional Supplements for NASH - a Randomized Prospective, Open Label Pilot Study
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease|Fatty Liver, Nonalcoholic
Interventions: BEHAVIORAL: Nutritional Counseling|DIETARY_SUPPLEMENT: Lactobacillus casei shirota (LCS)|OTHER: Nutritional Counseling and LCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Different Modalities for Pleural Adhesiolysis at Assuit University Hospital
Status: UNKNOWN
Conditions: Pleural Effusion
Interventions: DRUG: streptokinase|DRUG: MESNA (2-mercaptoethane sulfonate Na)|DEVICE: Medical thoracoscopy|DEVICE: Video assisted thoracoscopy (VATS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Iron Absorption and Requirements in Pregnancy and Lactation
Status: RECRUITING
Conditions: Iron Requirements|Pregnancy|Lactation|Infancy|Iron Absorption
Interventions: OTHER: CO-rebreathing|OTHER: Oral iron isotope administration (54Fe)|OTHER: Intravenous iron isotope administration (58Fe)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Depleted Donor Stem Cell Transplant in Children and Adults With Fanconi Anemia After Being Conditioned With a Regimen Containing Briquilimab
Status: RECRUITING
Conditions: Fanconi Anemia
Interventions: DRUG: JSP191|DEVICE: CliniMACS Prodigy System|BIOLOGICAL: Depleted Stem Cell Transplant|BIOLOGICAL: Rabbit Anti-Thymoglobulin (rATG)|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of GlowCaps Connect™ and Its Services on Hypertension Medication Adherence
Status: COMPLETED
Conditions: Medication Adherence
Interventions: OTHER: GlowCaps Connect system|OTHER: Glow cap system - deactivated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Omega-3 Fatty Acid Supplementation on Dry-AMD Progression
Status: NOT_YET_RECRUITING
Conditions: Age-Related Macular Degeneration
Interventions: DIETARY_SUPPLEMENT: Krill Oil 500 MG|DIETARY_SUPPLEMENT: Olive Oil 500MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Apple Flavanols on Risk of Cardiovascular Disease
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: Low PA apple puree|DIETARY_SUPPLEMENT: High PA apple puree|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Randomized, Crossover Bioequivalence Study of PL-ASA Versus Immediate Release Aspirin in Healthy Volunteers.
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Pharmaceutical-lipid aspirin (PL-ASA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Continuous Video- EEG Monitoring in the Acute Phase in Patients With a Cerebrovascular Attack- Randomisation of a Subpopulation Regarding Treatment Strategy
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: starting of anti-epileptic drug treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Eltrombopag/Boceprevir and Eltrombopag/Telaprevir Drug-Drug Interaction Study In Healthy Adult Subjects
Status: COMPLETED
Conditions: Thrombocytopaenia
Interventions: DRUG: Eltrombopag|DRUG: Boceprevir|DRUG: Telaprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Therapeutic Approaches to HAART-Induced Lipodystrophy
Status: COMPLETED
Conditions: HIV Infections|Lipodystrophy
Interventions: DRUG: Leptin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Italian Language Validation of The Eating Disorder Examination (EDE) - Child Version
Status: ACTIVE_NOT_RECRUITING
Conditions: Feeding and Eating Disorders of Childhood
Interventions: BEHAVIORAL: Administration of K-SADS-PL- Kiddie-Schedule for Affective Disorder and Schizophrenia-Present and Lifetime version (Kaufmann, 2002)|BEHAVIORAL: Administration of ChEDE- Child Version of the EatingDisorder Examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Palliative Care Consultations in the Skilled Nursing Facility (SNF) Setting
Status: COMPLETED
Conditions: Palliative Care|Advance Care Planning|Skilled Nursing Facilities
Interventions: OTHER: Palliative Care Consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Non Steroidal Anti Inflammatory Treatment for Post Operative Pericardial Effusion
Status: COMPLETED
Conditions: Pericardial Effusion
Interventions: DRUG: diclofenac|DRUG: diclofenac|DRUG: matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: EFFECT OF CYOLIPOLYSIS VERSUS CAVITATION WITH VEGAN DIET
Status: NOT_YET_RECRUITING
Conditions: Healthy Adult Women
Interventions: OTHER: Cryolipolysis and cavitation devices with vegan diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: QUILT-2.019: A Study of AMG 655 or AMG 479 in Combination With Gemcitabine for Treatment of Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Pancreas|Metastatic Pancreatic Cancer|Pancreatic Cancer
Interventions: OTHER: Placebo|DRUG: AMG 479|DRUG: AMG 655
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: LaCE (Lactobacillus Paracasei LPB27 On Early Childhood Eczema)
Status: NOT_YET_RECRUITING
Conditions: Eczema|Allergy
Interventions: DIETARY_SUPPLEMENT: Lactobacillus Paracasei LPB27|OTHER: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: OPS™ With Direct Anterior Approach (DAA)
Status: UNKNOWN
Conditions: Primary Total Hip Arthroplasty
Interventions: DEVICE: Primary Total Hip Replacement with Metafix™ femoral stem and Trinity™ acetabular cup or TriFit-CF™/TriFit-TS™ femoral stem and Trinity™ acetabular cup implanted by a single surgeon.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of ABI-H2158 in Healthy Volunteers and Patients With Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: ABI-H2158|DRUG: Placebo for ABI-H2158
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ziprasidone in Bipolar Disorder With Comorbid Lifetime Panic or Generalized Anxiety Disorder(GAD)
Status: COMPLETED
Conditions: Bipolar Disorder|Panic Disorder|Generalized Anxiety Disorder
Interventions: DRUG: Ziprasidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ectoin® Inhalation Solution on Subjects With Mild Bronchial Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: Drug-like Medical Device: Ectoin Inhalation Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Disturbed Blood Flow Induces Endothelial Dysfunction in Severe Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: retrograde flow|OTHER: oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cheetah - Sterile Glove and Clean Instrument Change at the Time of Wound Closure to Reduce Surgical Site Infection
Status: UNKNOWN
Conditions: Surgical Site Infection
Interventions: PROCEDURE: Change of gloves and sterile instruments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Myocardial Function Assessment in Patients With Coronary Artery Disease Using Noninvasive Myocardial Work
Status: ACTIVE_NOT_RECRUITING
Conditions: Noninvasive Myocardial Work|Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: Transthoracic echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Pharmacokinetics of Apatinib in Subjects With Impaired Renal Function
Status: UNKNOWN
Conditions: Subjects With Impaired Renal Function and Healthy Subjects
Interventions: DRUG: Apatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for the Treatment of Salmonella Infections in AIDS Patients
Status: COMPLETED
Conditions: HIV Infections|Salmonella Infections
Interventions: DRUG: Ceftriaxone sodium|DRUG: Ampicillin sodium|DRUG: Amoxicillin trihydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Folfox4 + Weekly Cetuximab vs Folfox 4+Biweekly Cetuximab by Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: FOLFOX4 (Oxaliplatin), Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conbercept Ophthalmic Injection for Patients With Macular Edema Caused by Branch Retinal Vein Occlusion
Status: COMPLETED
Conditions: Branch Retinal Vein Occlusion|Macular Edema
Interventions: DRUG: Conbercept ophthalmic injection|OTHER: sham/Conbercept ophthalmic injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MBT Versus HVPG in Identifying Responders to Portal Hypertension Therapy
Status: COMPLETED
Conditions: Chronic Liver Disease|Cirrhosis|Esophageal Varices|Portal Hypertension|Bleeding
Interventions: DEVICE: Methacetin (with Breath testing device)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Unilateral Versus Bilateral Endoscopic Lung Volume Reduction A Comparative Case Study
Status: UNKNOWN
Conditions: Pulmonary Emphysema
Interventions: DEVICE: IBV Implantation|DEVICE: IBV Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Management of Glucocorticoid-Induced Hyperglycemia in Hospitalized Patients
Status: COMPLETED
Conditions: Hyperglycemia|Diabetes Mellitus
Interventions: DRUG: Glargine insulin|DRUG: Lispro insulin|DRUG: NPH Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weekly Subcutaneous Alemtuzumab and Rituximab for Relapsed CLL
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Rituximab|DRUG: Alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REbif FLEXible Dosing in Early Multiple Sclerosis (MS)
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: RNF|DRUG: RNF|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Effectiveness of S-adenosyl-l-methionine (SAMe) for the Treatment of Major Depression
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: S-adenosyl-l-methionine|DRUG: Escitalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About Bivalent COVID-19 RNA Vaccine Candidate(s) in Healthy Infants and Children
Status: WITHDRAWN
Conditions: COVID-19
Interventions: BIOLOGICAL: Bivalent BNT162b2 (original/Omicron BA.4/BA.5) 3 microgram dose|BIOLOGICAL: Bivalent BNT162b2 (original/Omicron BA.4/BA.5) 6 microgram dose|BIOLOGICAL: Bivalent BNT162b2 (original/Omicron BA.4/BA.5) 10 microgram dose|BIOLOGICAL: Bivalent BNT162b2 (original/Omicron BA.4/BA.5) 1 microgram dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Enhancing Laparoscopic Skill Acquisition and Retention With Transcranial Direct-current Stimulation
Status: COMPLETED
Conditions: Laparoscopic Surgical Procedures
Interventions: DEVICE: Anodal Transcranial direct-current stimulation|DEVICE: Sham Transcranial direct-current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The RESPOND Registry
Status: COMPLETED
Conditions: Partial Thickness Wound|Pressure Ulcer|Venous Ulcer|Diabetic Ulcer|Surgical Wounds|Trauma Wounds|Draining Wounds|Chronic Vascular Ulcer
Interventions: DEVICE: PuraPly™ Antimicrobial Wound Matrix
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Implementation of Online Mindfulness-Based Stress Reduction Tailored for People With Multiple Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Mindfulness-Based Stress Reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Rotational Thromboelastometry for the Transfusion Management of Postpartum Hemorrhage After Vaginal or Cesarean Delivery
Status: TERMINATED
Conditions: Postpartum Hemorrhage
Interventions: DEVICE: Rotational Thromboelastometry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Block for Thoracoscopic Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Thoracic Neoplasms
Interventions: PROCEDURE: Erector Spinae Plane Block (for postoperative pain relief)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Topical Bupivacaine and Triamcinolone Acetonide Injection in the Relief of Pain After Endoscopic Submucosal Dissection for Gastric Neoplasia: A Randomized Double-blind, Placebo-controlled Trial
Status: COMPLETED
Conditions: Gastric Cancer|Gastric Adenoma
Interventions: DRUG: Saline|DRUG: Bupivacaine + saline|DRUG: Bupivacaine + triamcinolone acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Migraine STImulation Crisis of Migraine
Status: COMPLETED
Conditions: Migraine Without Aura
Interventions: DEVICE: Wristband with millimeter wave emission.|DEVICE: Placebo of wristband with millimeter wave emission.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT