pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Influence of Remote Ischemic Preconditioning on Acute Kidney Injury After Cardiac Surgery
Status: COMPLETED
Conditions: Acute Kidney Insufficiency|Acute Renal Insufficiency|Acute Kidney Injury|Ischemic Preconditioning
Interventions: PROCEDURE: Remote Ischemic Preconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of a Mastoid Device in Subjects With Ménière's Disease
Status: ENROLLING_BY_INVITATION
Conditions: Meniere Disease
Interventions: DEVICE: Mastoid Oscillator|DEVICE: Control Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adapting BA for Minimally Verbal Autistic Adults
Status: RECRUITING
Conditions: Autism|Depression|Autism Spectrum Disorder With Impaired Functional Language|Autism Spectrum Disorder
Interventions: BEHAVIORAL: BeatIt-MV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketotifen and Indomethacin Combination Treatment Clinical Trial for COVID-19
Status: COMPLETED
Conditions: COVID-19 Respiratory Infection
Interventions: DRUG: Ketotifen/Indomethacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Sofosbuvir Plus Ledipasvir in Egyptian Patients With COVID-19 Compared to Standard Treatment
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Sofosbuvir plus Ledipasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vorolanib (X-82) Combined With Checkpoint Inhibitors in Patients With Solid Tumors
Status: TERMINATED
Conditions: Solid Tumor|Hepatocellular Carcinoma|Gastric Cancer|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Vorolanib|DRUG: Nivolumab|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Maraviroc (UK-427,857) in Combination With Optimized Background Therapy Versus Optimized Background Therapy Alone for the Treatment of HIV-1 Infected Subjects
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Maraviroc (UK-427,857)|DRUG: optimized background therapy|DRUG: Maraviroc (UK-427,857)|DRUG: optimized background therapy|DRUG: optimized background therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MT2014-25: Haplo NK With SQ IL-15 in Adult Relapsed or Refractory AML Patients
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia
Interventions: BIOLOGICAL: IL-15
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Setmelanotide (RM-493), Melanocortin-4 Receptor (MC4R) Agonist, in Bardet-Biedl Syndrome (BBS) and Alström Syndrome (AS) Participants With Moderate to Severe Obesity
Status: COMPLETED
Conditions: Bardet Biedl Syndrome (BBS)|Alström Syndrome (AS)
Interventions: DRUG: Setmelanotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Safety and Efficacy of Prostate-sparing Radical Cystectomy
Status: RECRUITING
Conditions: Bladder Cancer
Interventions: PROCEDURE: Prostate capsule-sparing radical cystectomy|PROCEDURE: Nerve sparing radical cystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy to the Prostate and Dominant Intra-Prostatic Lesion (DIL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: MR-based image-guided, intensity-modulated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of a Health-Related Symptom Index for Persons Diagnosed With and Either Treated or Monitored for Anal High-Grade Squamous Intraepithelial Lesions (HSIL)
Status: COMPLETED
Conditions: Anal High-Grade Squamous Intraepithelial Lesions
Interventions: BEHAVIORAL: Assessment of Health-Related Quality
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TReatment Of Pulmonary HYpertension 1 Study
Status: UNKNOWN
Conditions: Pulmonary Arterial Hypertension
Interventions: DEVICE: Therapeutic Intra-Vascular UltraSound (TIVUS™) System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Relapsed or Refractory Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: etoposide|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: peripheral blood stem cell transplantation|PROCEDURE: syngeneic bone marrow transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: rAd-p53 Gene Therapy for Advanced Malignant Thyroid Tumors
Status: UNKNOWN
Conditions: Advanced Malignant Thyroid Tumors
Interventions: DRUG: rAd-p53 gene|PROCEDURE: surgery|DRUG: p53 gene therapy|RADIATION: p53 gene therapy with radioactive iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY900014 in Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: LY900014|DRUG: Insulin Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Electromechanical Profiling of the Long-QT Syndrome (LQTS)
Status: UNKNOWN
Conditions: Long QT Syndrome|Sudden Cardiac Death|Ventricular Tachycardia
Interventions: DIAGNOSTIC_TEST: Adenosine and epinephrine, isoprenaline provocation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sterile Allogeneic Spongioflex® Allograft as Partial Meniscal Replacement After Incomplete Meniscal Loss
Status: RECRUITING
Conditions: Meniscus Lesion
Interventions: PROCEDURE: Spongioflex®|OTHER: non-operated
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Effectiveness of Percutaneous and Transbronchial Argon-helium Cryoablation
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer
Interventions: PROCEDURE: Percutaneous or transbronchial argon-helium cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ph I/II Study of NMS-03305293+TMZ in Adult Patients With Recurrent Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma|Diffuse Glioma
Interventions: DRUG: NMS-03305293|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Vitamin D Fortified Milk
Status: COMPLETED
Conditions: 25-hydroxyvitamin D Serum Concentrations
Interventions: DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: No vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Protective Face Masks and Cardiopulmonary Parameters at Rest and During Exercise in Children
Status: UNKNOWN
Conditions: Face-masks|Exercise
Interventions: DIAGNOSTIC_TEST: Spirometry - baseline|DIAGNOSTIC_TEST: Spirometry - post CPET|DIAGNOSTIC_TEST: Nasal peak inspiratory flow - baseline|DIAGNOSTIC_TEST: Nasal peak inspiratory flow - post CPET|DIAGNOSTIC_TEST: Oxygen saturation|DIAGNOSTIC_TEST: Heart Rate|DIAGNOSTIC_TEST: End-tidal CO2|DIAGNOSTIC_TEST: Respiratory rate|DIAGNOSTIC_TEST: Temperature|DIAGNOSTIC_TEST: Humidity|DIAGNOSTIC_TEST: Cardiopulmonary exercise testing|DIAGNOSTIC_TEST: Discomfort level
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Preventive PICO on Surgical Wounds After Large Incisional Hernia Repair
Status: COMPLETED
Conditions: Incisional Hernia
Interventions: DEVICE: PICO DRESSING|DEVICE: MEPORE dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Trans Sodium Crocetinate (TSC) in Enhancing Tissue Oxygen Levels in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Trans-Sodium Crocetinate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nd:Yttrium Aluminum Garnet Laser Treatment for Lichen Sclerosus
Status: UNKNOWN
Conditions: Lichen Sclerosus|Lichen Sclerosus Et Atrophicus
Interventions: DEVICE: Nd:YAG Laser|DRUG: Topical corticosteroid Diprosone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Drug-drug Interaction and Safety Between HCP1306, RLD2302 and RLD2102 in Healthy Volunteers
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DRUG: HCP1306|DRUG: RLD2302|DRUG: RLD2102
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Supaglutide in Chinese Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Supaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: High-Density Lipoprotein (HDL) Modulation and Endothelial Function
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DRUG: atorvastatin (or other tolerated statin + Niaspan/placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of [225Ac]-FPI-2059 in Adult Participants With Solid Tumours
Status: RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma (PDAC)|Squamous Cell Carcinoma of Head and Neck|Colorectal Cancer|Gastric Cancer|Ewing Sarcoma|NTSR1 Expressing Solid Tumours|Neuroendocrine Differentiated (NED) Prostate Cancer
Interventions: DRUG: [225]-FPI-2059|DRUG: [111In]-FPI-2058
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Preliminary Efficacy of GLPG0634 in Methotrexate-refractory Active Rheumatoid Arthritis Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: GLPG0634
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of a Fractional Ablative Erbium Laser for Axillary Scarring for Hidradenitis Suppurativa Patients
Status: SUSPENDED
Conditions: Hidradenitis Suppurativa|Scarring
Interventions: DEVICE: Er: YAG laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Pro-vitamin A Biofortified Cassava on Vitamin A Status in Nigerian Preschool Children
Status: COMPLETED
Conditions: Vitamin A Deficiency
Interventions: OTHER: Pro-vitamin A biofortified cassava|OTHER: White cassava
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Safety and Tolerability of LBS-007 in Patients With Relapsed or Resistant Acute Leukaemias
Status: RECRUITING
Conditions: Relapsed or Resistant Acute Leukaemias
Interventions: DRUG: LBS-007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparsion of IV Dexmedetomidine, Tramdol and Ketamine for Post Spinal Anesthesia Shivering.
Status: UNKNOWN
Conditions: Post-Surgical Complication
Interventions: DRUG: Dexmedetomidine|DRUG: Ketamine|DRUG: Tramadol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Thulium Fiber Laser vs. Holmium:YAG Laser for the Ureteroscopic Treatment of Patients With Urinary Stone Disease
Status: RECRUITING
Conditions: Kidney Stone|Ureteral Stone
Interventions: DEVICE: Laser lithotripsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tarceva (Erlotinib) and Standard of Care Chemotherapy in Patients With Advanced, Recurrent, or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Alimta or Taxotere|DRUG: erlotinib [Tarceva]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apatinib Combined With EGFR-TKI for Advanced Slow-progressed EGFR-TKI Resistant NSCLC
Status: UNKNOWN
Conditions: NSCLC|Apatinib|EGFR-TKI
Interventions: DRUG: Apatinib（Tab. 500mg/d） combined with EGFR-TKI（as previously）
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Trial to Investigate the Biological Equivalence of 5 × 10 mg Tablets and 2 × 25 mg Tablets of Daridorexant in Healthy Male and Female Japanese Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Daridorexant 10 mg|DRUG: Daridorexant 25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Use of RF in Premature Jowl and Neck Laxity Following Facialplasty
Status: COMPLETED
Conditions: Premature Jowl and Neck Laxity Following Facialplasty
Interventions: DEVICE: AccuTite/FaceTite
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Venetoclax, Obinutuzumab and Bendamustine in High Tumor Burden Follicular Lymphoma as Front Line Therapy
Status: COMPLETED
Conditions: Follicular Lymphoma|Non-Hodgkin's Lymphoma Follicular|Non-Hodgkin's Lymphoma, Adult High Grade
Interventions: DRUG: Induction Venetoclax|DRUG: Maintenance Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: POEM Trial: Multi-center Study Comparing Endoscopic Pneumodilation and Per Oral Endoscopic Myotomy (POEM)
Status: RECRUITING
Conditions: Achalasia
Interventions: PROCEDURE: PD|PROCEDURE: POEM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spatial Repellent Products for Control of Vector Borne Diseases - Malaria - Zambia (SR-M-ZM)
Status: WITHDRAWN
Conditions: Malaria
Interventions: DEVICE: Spatial Repellent product with active ingredient (SHIELD)|DEVICE: Active Ingredient|DEVICE: Spatial Repellent product without active ingredient (SHIELD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Irinotecan in Treating Patients With Advanced Neuroendocrine Tumors
Status: COMPLETED
Conditions: Carcinoma of Unknown Primary|Neuroendocrine Carcinoma|Neuroendocrine Carcinoma of the Skin
Interventions: DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effect of Enzyme Replacement Therapy in Mucopolysaccharidosis
Status: COMPLETED
Conditions: Mucopolysaccharidosis
Interventions: DRUG: Enzyme Replacement Agent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vertebroplasty for the Treatment of Fractures Due to Osteoporosis
Status: COMPLETED
Conditions: Spinal Fractures|Osteoporosis
Interventions: DEVICE: Percutaneous vertebroplasty|PROCEDURE: Sham vertebroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Docetaxel Versus Vinorelbine as 1st Line Treatment in Elderly Patients With Non-Small-Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Docetaxel|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Improve Outcomes for Survivors of Traumatic Brain Injury in Latin America
Status: UNKNOWN
Conditions: Traumatic Brain Injury|Brain Injuries
Interventions: DEVICE: Parenchymal Intracranial pressure monitor|OTHER: Treatment based on clinical and imaging observations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pyrotinib Combined With Capecitabine and Bevacizumab for Patients With HER2 Positive Breast Cancer and Brain Metastases
Status: RECRUITING
Conditions: Breast Cancer With Brain Metastases
Interventions: DRUG: pyrotinib+capecitabine+bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GLobal Assessment of Plaque reGression With a PCSK9 antibOdy as Measured by intraVascular Ultrasound
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: BIOLOGICAL: Evolocumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Reduce Readmissions Using Motivational Interviewing and Interactive Voice Response
Status: COMPLETED
Conditions: Congestive Heart Failure (CHF)|Chronic Obstructive Pulmonary Disease (COPD)
Interventions: BEHAVIORAL: MI + IVR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Runzao Zhiyang Capsule to Treat Chronic Eczema
Status: UNKNOWN
Conditions: Chronic Eczema
Interventions: DRUG: Runzao zhiyang capsule|DRUG: Runzaozhiyang capsule agent simulation|DRUG: Urea cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy With or Without Radiation or Surgery in Treating Participants With Oligometastatic Esophageal or Gastric Cancer
Status: RECRUITING
Conditions: Gastric Adenocarcinoma|Oligometastasis|Stage IV Esophageal Adenocarcinoma AJCC v7|Stage IV Esophageal Cancer AJCC v7|Stage IV Gastric Cancer AJCC v7
Interventions: DRUG: Capecitabine|DRUG: Chemotherapy|PROCEDURE: Conventional Surgery|DRUG: Fluorouracil|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastric Residuals in Preterm Infants
Status: COMPLETED
Conditions: Early Enteral Feeding Advancement|Nutrition|Preterm Infants
Interventions: PROCEDURE: No check of gastric residuals for early enteral feeding advancement|PROCEDURE: Routine check of gastric residuals for early enteral feeding advancement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-human Study of 225Ac-PSMA-Trillium (BAY 3563254) in Participants With Advanced Metastatic Castration-resistant Prostate Cancer (mCRPC)
Status: RECRUITING
Conditions: Advanced Metastatic Castration-resistant Prostate Cancer|Prostate Specific Membrane Antigen (PSMA) Expression
Interventions: DRUG: 225Ac-PSMA-Trillium (BAY3563254)|DRUG: Tris-POC (BAY2688901)|DRUG: 111In-PSMA-Trillium (BAY3632687)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Alvision™ Interventional Cardiology Diagnostic Catheter Post Market Clinical Follow-up (PMCF) Study.
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Disease|Vascular Diseases
Interventions: DEVICE: Alvision™ Interventional Cardiology Diagnostic Catheter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Study of Physiological and Cerebrovascular Reactivity in Depression, at the Three Phases of Emotion
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: BEHAVIORAL: psychometric tests|DEVICE: MRI|DEVICE: transcranial doppler and TPI|BEHAVIORAL: explicitative interview
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Epicardial Mini-Maze Versus Catheter Ablation for the Management of Persistent Atrial Fibrillation
Status: WITHDRAWN
Conditions: Persistent Atrial Fibrillation
Interventions: PROCEDURE: Catheter ablation|PROCEDURE: Mini-maze surgical procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Long-term Mild Hypothermia for Severe Traumatic Brain Injury
Status: COMPLETED
Conditions: Brain Injuries|Craniocerebral Trauma
Interventions: OTHER: Long-term mild hypothermia|OTHER: Normothermia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Experience With the Zimmer Trabecular Metal (TM) Glenoid in Total Shoulder Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis of the Shoulder
Interventions: DEVICE: Zimmer TM Glenoid|DEVICE: Cemented Glenoid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Technology Knowledge Optimization in Type 1 Diabetes (TeKnO T1D): Parents
Status: NOT_YET_RECRUITING
Conditions: Type 1 Diabetes
Interventions: OTHER: TeKnO T1D: Parents
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Induction of Anesthesia With Sevoflurane Preserving Spontaneous Breathing: Cardiorespiratory Effects.
Status: COMPLETED
Conditions: Anesthesia Intubation Complication|Cardiovascular Complication|Intubation
Interventions: DRUG: Sevoflurane inhalant product|DRUG: Propofol Fresenius
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Diet Based on Low Sodium and Slowly Absorbed Carbohydrates on the Incidence of Refeeding Syndrome in Patients With Head and Neck Cancer
Status: COMPLETED
Conditions: Refeeding Syndrome
Interventions: DIETARY_SUPPLEMENT: Low sodium diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Collecting and Studying Tissue Samples From Patients With HIV-Associated Malignancies
Status: TERMINATED
Conditions: Lung Cancer|Lymphoma
Interventions: GENETIC: DNA analysis|GENETIC: RNA analysis|GENETIC: gene expression analysis|GENETIC: polymorphism analysis|OTHER: biologic sample preservation procedure|OTHER: flow cytometry|OTHER: medical chart review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tocilizumab for the Prevention of Graft Failure and GVHD in Haplo-Cord Transplantation
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematologic Malignancy|Bone Marrow Transplant
Interventions: DRUG: Tocilizumab|DRUG: Fludarabine|DRUG: Melphalan|DRUG: Anti-thymocyte globulin (rabbit)|RADIATION: Total Body Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parents Helping Infants Study: Educational Intervention to Change the Knowledge, Attitudes and Behaviour of New Parents About Early Infant Crying
Status: COMPLETED
Conditions: Shaken Baby Syndrome
Interventions: BEHAVIORAL: The Period of PURPLE Crying Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Moral Judgements and Choices of Caregivers in the Time of COVID-19 Pandemic
Status: UNKNOWN
Conditions: Morals
Interventions: BEHAVIORAL: Choices and judgements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pharmacokinetic Study of Oral IXAZOMIB in Cancer Patients With Liver Dysfunction
Status: COMPLETED
Conditions: Advanced Solid Tumors|Hematologic Malignancies
Interventions: DRUG: IXAZOMIB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Global Postural Reeducation on Low Back Pain Patients With Lower Cross Syndrome
Status: COMPLETED
Conditions: Low Back Pain, Postural
Interventions: PROCEDURE: Global postural reeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sorafenib Tosylate and Erlotinib Hydrochloride in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gallbladder Cancer or Cholangiocarcinoma
Status: COMPLETED
Conditions: Extrahepatic Bile Duct Adenocarcinoma|Gallbladder Adenocarcinoma|Gallbladder Adenocarcinoma With Squamous Metaplasia|Hilar Cholangiocarcinoma|Recurrent Extrahepatic Bile Duct Carcinoma|Recurrent Gallbladder Carcinoma|Undifferentiated Gallbladder Carcinoma|Unresectable Extrahepatic Bile Duct Carcinoma|Unresectable Gallbladder Carcinoma
Interventions: DRUG: Erlotinib Hydrochloride|DRUG: Sorafenib Tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Aerobic and Resistance Exercise Training in Metastatic Renal Cell Carcinoma
Status: TERMINATED
Conditions: Renal Cell Carcinoma Metastatic
Interventions: OTHER: Combined Aerobic and Resistance Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Empagliflozin Reversal of Arterial StiffnEss in Aging
Status: NOT_YET_RECRUITING
Conditions: Aging|Arterial Stiffness
Interventions: DRUG: Empagliflozin 10 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study of Duvelisib Versus Ofatumumab in Patients With Relapsed or Refractory CLL/SLL (DUO)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Duvelisib|DRUG: Ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pro-inflammatory Cytokines Profile and Mortality Rate of Critically Ill Septic Patients Following Plasmapheresis
Status: UNKNOWN
Conditions: Severe Sepsis
Interventions: PROCEDURE: plasmapheresis|OTHER: plasmapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant and Adjuvant Checkpoint Blockade
Status: COMPLETED
Conditions: Cutaneous Melanoma|Mucosal Melanoma|Ocular Melanoma|Stage III Acral Lentiginous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIB Uveal Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IIIC Uveal Melanoma AJCC v7|Stage IV Acral Lentiginous Melanoma AJCC v6 and v7|Stage IV Cutaneous Melanoma AJCC v6 and v7|Stage IV Uveal Melanoma AJCC v7
Interventions: BIOLOGICAL: Ipilimumab|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab|BIOLOGICAL: Relatlimab|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Investigation of Prostate Artery Embolization (PAE) Before Radical Prostatectomy in Prostate Cancer Patients
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DEVICE: Prostate artery embolization (PAE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Study Safety, Tolerability and Pharmacokinetics of AZD1305 in Healthy Male Japanese Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD1305|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: BMX Alpha Registry: a Post-market Registry of the BioMatrix Alpha TM
Status: UNKNOWN
Conditions: Coronary Artery Disease|Stable Angina|Ischemia|Acute Coronary Syndrome|NSTEMI|STEMI
Interventions: DEVICE: BioMatrix AlphaTM
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An LGBT-Competency Program for Mental Health Professionals in Romania
Status: COMPLETED
Conditions: Stigma, Social|Gays|Lesbians|Bisexuals|Gender Dysphoria
Interventions: BEHAVIORAL: Mobile web training LGBT mental health|BEHAVIORAL: In-person training LGBT mental health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Assess the Efficacy and Safety of DCC-2618 and Sunitinib in Patients With Advanced Gastrointestinal Stromal Tumors After Treatment With Imatinib
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumor(GIST)
Interventions: DRUG: Ripretinib|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab Combined With Bevacizumab With or Without Agonist Anti-CD40 CDX-1140 for the Treatment of Patients With Recurrent Ovarian Cancer
Status: RECRUITING
Conditions: Ovarian Clear Cell Adenocarcinoma|Platinum-Sensitive Ovarian Carcinoma|Recurrent Endometrial Serous Adenocarcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Fallopian Tube Endometrioid Adenocarcinoma|Recurrent Fallopian Tube Serous Adenocarcinoma|Recurrent Ovarian Carcinoma|Recurrent Ovarian Clear Cell Adenocarcinoma|Recurrent Ovarian Endometrioid Adenocarcinoma|Recurrent Ovarian Serous Adenocarcinoma|Recurrent Platinum-Resistant Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Recurrent Primary Peritoneal Clear Cell Adenocarcinoma|Recurrent Primary Peritoneal Endometrioid Adenocarcinoma|Recurrent Primary Peritoneal Serous Adenocarcinoma
Interventions: BIOLOGICAL: Anti-CD40 Agonist Monoclonal Antibody CDX-1140|BIOLOGICAL: Bevacizumab|BIOLOGICAL: Pembrolizumab|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Effectiveness of PEEK Interference Screws in Anterior Cruciate Ligament Reconstruction
Status: UNKNOWN
Conditions: PEEK Interference Screw; Fixation; Anterior Cruciate Ligament Reconstruction
Interventions: DEVICE: Interference Screws
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gabapentin Versus Trospium Chloride for Prevention of a Catheter-related Bladder Discomfort Inside the ICU
Status: RECRUITING
Conditions: Catheter-related Bladder Discomfort (CRBD)
Interventions: DRUG: Gabapentin (Gaptin ®) 400mg oral capsule once|DRUG: Trospium chloride slow release (Trospikan ® SR) 60mg oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety of UC-MSC Transfusion for ACLF Patients
Status: UNKNOWN
Conditions: Acute-On-Chronic Liver Failure
Interventions: GENETIC: Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain
Status: RECRUITING
Conditions: Pain, Postoperative|Opioid Use|Perioperative Complication|Heart Diseases
Interventions: DRUG: bupivacaine liposome injectable suspension|DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study of Wearable Device in Assessing Respiratory Condition Change of Patients With Exacerbation of COPD
Status: COMPLETED
Conditions: COPD Exacerbation
Interventions: DEVICE: SenseGuard
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Study of a Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 11 Years in Malaysia
Status: COMPLETED
Conditions: Dengue Fever|Dengue Hemorrhagic Fever
Interventions: BIOLOGICAL: Live, attenuated, recombinant dengue serotypes 1, 2, 3, and 4 virus|BIOLOGICAL: Placebo: NaCl 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Use of NAC in Alleviation of Hangover Symptoms
Status: COMPLETED
Conditions: Hangover Symptoms, NAC
Interventions: DIETARY_SUPPLEMENT: N Acetyl Cysteine|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I/II Study of Pentostatin Combined With Tacrolimus and Mini-Methotrexate for GVHD Prevention After MUD BMT
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: DRUG: Pentostatin|DRUG: Tacrolimus|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of HMP on Diabetic Microangiopaemia in T2DM
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Diabetic Angiopathies
Interventions: DRUG: Heart-Protecting Musk Pill|DRUG: Valsartan Capsules|DRUG: Calcium Dobesilate Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Modifying the Impact of ICU-Associated Neurological Dysfunction-USA (MIND-USA) Study
Status: COMPLETED
Conditions: Delirium|Impaired Cognition|Long Term Psychologic Disorders
Interventions: DRUG: Haloperidol|DRUG: Ziprasidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: [PETDE10] Imaging of PDE10A Enzyme Levels in Huntington's Disease Gene Expansion Carriers and Healthy Controls With PET.
Status: COMPLETED
Conditions: Huntington's Disease
Interventions: RADIATION: PET Imaging with [18F]MNI-659
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors
Status: UNKNOWN
Conditions: Ovarian Granulosa Cell Tumor|Ovarian Gynandroblastoma|Ovarian Sertoli-Leydig Cell Tumor|Ovarian Sex Cord Tumor With Annular Tubules|Ovarian Sex Cord-Stromal Tumor|Ovarian Sex Cord-Stromal Tumor, Not Otherwise Specified|Ovarian Steroid Cell Tumor
Interventions: BIOLOGICAL: Bleomycin Sulfate|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Etoposide Phosphate|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Portico Next Generation Approval Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Symptomatic Severe Aortic Stenosis
Interventions: DEVICE: Portico™ NG (Navitor) Valve and FlexNav™ Delivery System|DEVICE: Navitor Titan Valve (35mm) Valve and Large FlexNav™ Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Thymoglobuline® Induction Therapy in Adult Recipients of Donated After Cardiac Death Kidney Transplant
Status: COMPLETED
Conditions: End-stage Renal Disease
Interventions: BIOLOGICAL: Rabbit Anti-thymocyte Immunoglobulin|DRUG: Tacrolimus|DRUG: Methylprednisolone|DRUG: Mycophenolate mofetil|DRUG: Mycophenolate Na|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Probiotics on GI Symptoms
Status: COMPLETED
Conditions: Gastrointestinal Symptoms
Interventions: DIETARY_SUPPLEMENT: Ecologic® PERFORMANCE|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Liraglutide on Microbiome in Obesity
Status: UNKNOWN
Conditions: Obesity|Weight Loss|Microbiome
Interventions: DRUG: Liraglutide 6 MG/ML [Saxenda]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot, Prospective, Non-randomized Evaluation of the Safety of Anakinra Plus Standard Chemotherapy
Status: UNKNOWN
Conditions: Pancreas Cancer
Interventions: DRUG: anakinra|DRUG: Oxaliplatin|DRUG: Irinotecan|DRUG: fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Open Label Study to Assess the Long-term Safety, Tolerability and Efficacy of Ambrisentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Status: TERMINATED
Conditions: Hypertension
Interventions: DRUG: Ambrisentan 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study Investigating the Efficacy of a Stannous Fluoride Dentifrice in Improving Gingival Health After Twice Daily Use for 3 Weeks
Status: COMPLETED
Conditions: Gingivitis
Interventions: DRUG: Sensodyne Repair and Protect|DRUG: Colgate Cavity Protection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Diagnostic Accuracy of Luminal Index and MP MRI for Accelerated deTEction of Significant Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: Luminal Index MRI (LI-MRI)|DIAGNOSTIC_TEST: LI-MRI targeted prostate biopsy|DIAGNOSTIC_TEST: Plasma methylation signature (ctMethSig)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dexmedetomidine for Sedation in Total Knee Replacements
Status: COMPLETED
Conditions: Post-operative Pain for Total Knee Arthroplasty
Interventions: DRUG: Dexmedetomidine|DRUG: Bupivicaine|DRUG: Normal Saline|DRUG: Fentanyl|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Spironolactone and Insulin Resistance in Chronic Heart Failure (CHF)
Status: COMPLETED
Conditions: Chronic Stable Heart Failure
Interventions: DRUG: spironolactone + furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Intraoperative Fluid Management on Electrolyte and Acid-base Variables
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Normal Saline|DRUG: Lactated Ringer|DRUG: Normosol-R Inj
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of VX-150 in Treating Subjects With Pain Caused by Small Fiber Neuropathy
Status: COMPLETED
Conditions: Small Fiber Neuropathy
Interventions: DRUG: VX-150|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rates of Middle Meatal Synechia Formation Following Functional Endoscopic Sinus Surgery
Status: COMPLETED
Conditions: Sinusitis
Interventions: DEVICE: Silastic Spacer|DEVICE: Merocel Spacer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study of Jianfei Kangfu Cao in the Treatment of pSS-ILD
Status: UNKNOWN
Conditions: Primary Sjogren's Syndrome|Interstitial Lung Disease
Interventions: BEHAVIORAL: Jianfei Kangfu Cao|BEHAVIORAL: lung rehabilitation training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Plasmatic L-AScorbic Acid in MYelodyplastic Syndroms and Controls
Status: COMPLETED
Conditions: Myelodysplastic Syndrome|Secondary Acute Myeloid Leukemia
Interventions: OTHER: Samples|OTHER: Quality of life questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy Study in Infant With SBS
Status: TERMINATED
Conditions: Short Bowel Syndrome
Interventions: DRUG: NTRA-9620|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dried Blood Spots for SARS-CoV-2 Serology (COVID-19).
Status: COMPLETED
Conditions: SARS-CoV-2 Acute Respiratory Disease
Interventions: DIAGNOSTIC_TEST: Dried blood spot and venous blood collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Biological Technique in Upper Canine Retraction and Levels of Discomfort
Status: COMPLETED
Conditions: Malocclusion, Angle Class II, Division 1
Interventions: BIOLOGICAL: i-PRF|PROCEDURE: canine retraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Valcyte® as an add-on Therapy in Patients With Malignant Glioblastoma and Cytomegalovirus (CMV) Infection
Status: COMPLETED
Conditions: Glioblastoma Multiforme|Cytomegalovirus Infection
Interventions: DRUG: Valganciclovir (Valcyte)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Hyperimmune Bovine Colostrum - TRAVELAN™ for Patients With Chronic Hepatitis C Virus Infection Not Responding to Standard Therapy
Status: WITHDRAWN
Conditions: Asymptomatic Chronic HCV Carriers
Interventions: DRUG: Bovine Colostrum Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Directly Observed Therapy Short Course-Plus Versus DOTS for Retreatment of Relapsed Pulmonary Tuberculosis in Guangzhou
Status: COMPLETED
Conditions: Pulmonary Tuberculosis
Interventions: OTHER: Directly Observed Therapy (DOTS) plus|OTHER: Directly Observed Therapy (DOTS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Multiple-, Single- and Zero-dose of Ciprofloxacin Prophylaxis in Retrograde Intrarenal Surgery
Status: UNKNOWN
Conditions: Kidney Stones
Interventions: DRUG: Multiple-dose of Ciprofloxacin prophylaxis|DRUG: Single-dose of Ciprofloxacin prophylaxis|DRUG: Zero-dose of Ciprofloxacin prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Idarubicin Plus Cytarabine (IA) vs IA Plus Cladribine (IAC) as Induction Regimen to Treat Initially Diagnosed Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: IAC regimen|DRUG: IA regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT