pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Clinical Trial to Evaluate R-COMP Versus R-CHOP in Newly Diagnosed Patients With Non-localised Diffuse Large B-cell Lymphoma (DLBCL)/Follicular Lymphoma Grade IIIb
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: RCOMP|DRUG: RCHOP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Sphenopalatine Ganglion Acupuncture on Nasal Function
Status: COMPLETED
Conditions: Healthy
Interventions: PROCEDURE: active sphenopalatine ganglion acupuncture|PROCEDURE: sham sphenopalatine ganglion acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Experimental Heat Patch
Status: COMPLETED
Conditions: Effects of Heat|Tolerability|Adhesiveness|Dermal Irritation
Interventions: DEVICE: Thermal Adhesion Patch|DEVICE: Marketed Thermal Adhesion Patch|DEVICE: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Multi-Center Study in Men With Acquired Hypogonadotropic Hypogonadism to Compare Changes in Body Composition and Metabolic Parameters With Diet and Exercise in Conjunction With Treatment With 12.5 mg or 25 mg Enclomiphene
Status: COMPLETED
Conditions: Acquired Hypogonadotropic Hypogonadism|Obesity
Interventions: DRUG: Placebo|DRUG: Enclomiphene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lighthouse Project on Dementia, Ulm, Germany
Status: UNKNOWN
Conditions: Dementia
Interventions: BEHAVIORAL: advice (e.g. medical and social aspects, care, support at home, residential advice, legal aspects, demonstration of help and support for the relatives)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effectiveness of Motor-motor and Motor-cognitive Dual-task Training Interventions on Balance in People With Parkinson's Disease: a Feasibility Study
Status: RECRUITING
Conditions: Parkinson's Disease
Interventions: OTHER: motor-motor dual-task training|OTHER: motor-cognitive dual-task training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: How to Prevent Heart Failure Readmission by Using Lung Impedance Device (HOPE-HF Study)
Status: UNKNOWN
Conditions: Heart Failure Acute
Interventions: DIAGNOSTIC_TEST: Lung Impedance Device|DRUG: Anti-congestive treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of the Effects of Morton's Neuroma on Foot Pressure Distribution and Gait Parameters in Pes Planus and Pes Cavus Patients
Status: COMPLETED
Conditions: Morton Neuroma|Pes Planus|Pes Cavus
Interventions: OTHER: Comparison of gait and foot pressure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: L-Glutamine Therapy for Sickle Cell Anemia and Sickle ß0 Thalassemia
Status: COMPLETED
Conditions: Sickle Cell Anemia|Thalassemia
Interventions: DRUG: L-glutamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Combination of Low-dose Rituximab and ATRA as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia
Status: UNKNOWN
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Rituximab|DRUG: All-trans retinoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deep sequencIng in Cutaneous Squamous CEll caRciNomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Cutaneous Squamous Cell Carcinoma|Cutaneous Squamous Cell Carcinoma of the Head and Neck|Neoplasms|Non-melanoma Skin Cancer
Interventions: DRUG: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Whole-Body MRI and Conventional Imaging in Detecting Distant Metastases in Young Patients With Solid Tumors or Lymphoma
Status: UNKNOWN
Conditions: Lymphoma|Neuroblastoma|Sarcoma
Interventions: PROCEDURE: computed tomography|PROCEDURE: magnetic resonance imaging|PROCEDURE: positron emission tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Conversion of Prograf to Advagraf in Pediatric Renal Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplantation|Pediatric Patients|Maintenance With Tacrolimus
Interventions: DRUG: tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Treatment Stratification Trial Using Neck Dissection-Driven Selection to Improve Quality of Life for Low Risk Patients With HPV+ Oropharyngeal Squamous Cell Cancer
Status: COMPLETED
Conditions: Oropharyngeal Squamous Cell Cancer
Interventions: PROCEDURE: Neck Dissection|PROCEDURE: Standard-of-Care (SOC) Transoral Surgery of Primary Site|RADIATION: SOC Radiation|DRUG: SOC Carboplatin|DRUG: SOC Paclitaxel|PROCEDURE: Videofluoroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Care for Children Hospitalized With Community-acquired Pneumonia: Novel Diagnostics
Status: RECRUITING
Conditions: Community-acquired Pneumonia
Interventions: DIAGNOSTIC_TEST: MeMed BV + Usual Care|OTHER: Usual Care Alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Kinetics of Elimination of Methotrexate and Its Major Metabolite 7-OH-methotrexate for Observant Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Urine samples taken to measure methotrexate and its major metabolite 7-OH-methotrexate level
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ticagrelor in Patients With ST Elevation Myocardial Infarction Treated With Pharmacological Thrombolysis
Status: COMPLETED
Conditions: Acute ST Segment Elevation Myocardial Infarction|Thrombolysis in Myocardial Infarction Flow
Interventions: DRUG: Ticagrelor 180 mg|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AZithromycin Therapy in Preschoolers With a Severe Wheezing Episode Diagnosed at the Emergency Department
Status: RECRUITING
Conditions: Asthma|Wheezing
Interventions: DRUG: Azithromycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SpO2 Comparison Between Commercial Smartwatch and Medical-grade Pulse Oximeter During Hypoxia
Status: ENROLLING_BY_INVITATION
Conditions: Hypoxia|Pulse Oximetry
Interventions: OTHER: Breathing mixtures of O2 and N2 and monitoring SpO2 on finger and left wrist
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 1 Trial of Ipilimumab and GVAX in Patients With Metastatic Castration-resistant Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: GVAX and ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3-AP and Gemcitabine in Treating Patients With Refractory Metastatic Breast Cancer
Status: TERMINATED
Conditions: Male Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: triapine|DRUG: gemcitabine hydrochloride|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the ACAT Inhibitor CS-505 (Pactimibe) for Reducing the Progression of Carotid Artery Disease. This Study is Also Known as CAPTIVATE.
Status: TERMINATED
Conditions: Atherosclerosis|Heterozygous Familial Hypercholesterolemia
Interventions: DRUG: Pactimibe sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers of Response to Ketamine in Depression: MRI and Blood Assays Before and After Open Label Intranasal Ketamine
Status: COMPLETED
Conditions: Depressive Disorder, Treatment-Resistant
Interventions: DRUG: Ketamine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pembrolizumab and Trametinib in Treating Patients With Stage IV Non-Small Cell Lung Cancer and KRAS Gene Mutations
Status: ACTIVE_NOT_RECRUITING
Conditions: KRAS Gene Mutation|Metastatic Non-Squamous Non-Small Cell Lung Carcinoma|Recurrent Non-Squamous Non-Small Cell Lung Carcinoma|Stage IV Non-Small Cell Lung Cancer AJCC v7
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GL-ONC1 Oncolytic Immunotherapy in Patients With Recurrent or Refractory Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Peritoneal Carcinomatosis|Fallopian Tube Cancer
Interventions: BIOLOGICAL: GL-ONC1 alone, or in combination with chemotherapy with or without bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prognostic Value of Cardiovascular Risk of sST2 and Troponin I-hs in Patients With Acute Chest Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Chest Pain|Acute Coronary Syndrome
Interventions: OTHER: Multimarker approach in acute coronary syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Anesthesia on Neurodevelopmental Outcome (NDO)
Status: COMPLETED
Conditions: Anesthesia; Adverse Effect|Congenital Heart Disease|Neurodevelopmental Disorders
Interventions: DRUG: Isoflurane|DRUG: Fentanyl (high dose)|DRUG: Fentanyl (low dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: BK Virus Post-Kidney Transplant: New Practice Versus Traditional Approach
Status: WITHDRAWN
Conditions: BK Virus Infection|BK Virus Nephropathy
Interventions: OTHER: New Protocol - BK viremia or BK virus nephropathy|OTHER: Standard Protocol - BK viremia or BK virus nephropathy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Family Based Treatment of Depressed Adolescents (AHUS)
Status: TERMINATED
Conditions: Depressive Disorder|Mood Disorder|Major Depression
Interventions: BEHAVIORAL: Attachment Based Family Therapy|BEHAVIORAL: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1a Study of PN20 in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Chemotherapy-induced Thrombocytopenia|Immune Thrombocytopenic Purpura
Interventions: DRUG: PN20|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Simvastatin and Fenofibrate vs Simvastatin Alone in Patients With Type 2 Diabetes Mellitus and Acute Coronary Syndrome
Status: UNKNOWN
Conditions: Acute Coronary Syndrome|Diabetes Mellitus, Type 2|Hypertriglyceridemia
Interventions: DRUG: Fenofibrate|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of Two Different Formulations of Olmesartan Medoxomil/ Hydrochlorothiazide After a Single Oral Dose Administration Under Fasting Conditions
Status: UNKNOWN
Conditions: Bioequivalence
Interventions: DRUG: Olmesartan Medoxomil/Hydrochlorothiazide 40 Mg/25 Mg film-coated tablets for oral use|DRUG: Olmetec® Plus 40 Mg/25 Mg film-coated tablets for oral use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: PCI Treatment/Gemcitabine & Chemotherapy vs Chemotherapy Alone in Patients With Inoperable Extrahepatic Bile Duct Cancer
Status: TERMINATED
Conditions: Cholangiocarcinoma
Interventions: DRUG: Fimaporfin and Gemcitabine|DRUG: Gemcitabine/Cisplatin chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of HD-P023 and Co-administration of Teneligliptin and Empagliflozin High in Healthy Volunteers
Status: NOT_YET_RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: HD-P023|DRUG: Teneligliptin|DRUG: Empagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IRESSA™ In Combo With Xeloda™ in Advanced Colorectal Cancer Patients After 1st-Line Chemo Failure
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Gefitinib and capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of TAK-994 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: TAK-994|DRUG: TAK-994 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: BIOLOGICAL: Sacituzumab tirumotecan|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Apneic Oxygenation by Transnasal Humidified Rapid Insufflation Ventilator Exchange Obstructive Sleep Apnea Patients
Status: NOT_YET_RECRUITING
Conditions: Obstructive Sleep Apnea Syndrome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Basophil Activation Test to Diagnose Food Allergy
Status: UNKNOWN
Conditions: Food Allergy|Food Allergy in Infants|Food Allergy in Children|Food Allergen Sensitisation|Milk Allergy|Egg Allergy|Nut Allergy
Interventions: DIAGNOSTIC_TEST: Oral food challenge
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Facilitating Functional Independence in Patients Receiving Prolonged Mechanical Ventilation
Status: UNKNOWN
Conditions: Muscle Weakness
Interventions: DEVICE: Neuromuscular electrical Stimulation (NMES)|DEVICE: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy and Safety of LCZ696 Alone and in Combination With Amlodipine in Patients With Hypertension
Status: WITHDRAWN
Conditions: Hypertension
Interventions: DRUG: LCZ696|DRUG: Amlodipine|DRUG: LCZ696 and amlodipine combination|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of PEG-somatropin in the Treatment of Children With Idiopathic Short Stature
Status: UNKNOWN
Conditions: Dwarfism
Interventions: DRUG: Jintrolong® low dose group|DRUG: Jintrolong® high dose group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Value of Left Colic Artery in Laparoscopic Radical Rectectomy
Status: UNKNOWN
Conditions: Overall Survival|Postoperative Complications
Interventions: PROCEDURE: LCA-nP|PROCEDURE: LCA-P
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects Whole Body Vibration in Ergospirometrics Parameters and Quality of Life
Status: COMPLETED
Conditions: Healthy
Interventions: PROCEDURE: WHOLE BODY VIBRATION
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sealing of Initial Occlusal Caries Using Fissure Sealants
Status: NOT_YET_RECRUITING
Conditions: Caries; Initial
Interventions: OTHER: BioCoat® by Premier®|OTHER: 3M™ Clinpro™ Sealant.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oxaliplatin and Capecitabine in Patients With Unresectable Cholangiocarcinoma
Status: COMPLETED
Conditions: Cancer of the Gallbladder|Cancer of the Biliary Tract
Interventions: DRUG: Capecitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of JTT-302 in Subjects With Low HDL-C Levels
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: JTT-302|DRUG: JTT-302|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Ritonavir Plus Lamivudine Plus Zidovudine in HIV-Infected Pregnant Women and Their Babies
Status: COMPLETED
Conditions: HIV Infections|Pregnancy
Interventions: DRUG: Ritonavir|DRUG: Lamivudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Individualized Nutritional Care Bundle for Home Nursing Patients With Pressure Injuries.
Status: RECRUITING
Conditions: Wounds and Injuries|Malnutrition|Nutritional Deficiency|Wound Healing Delayed|Nurse's Role
Interventions: OTHER: Individualized and Protocolized Nutritional Care Bundle|OTHER: Optimized Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NAVITAS and ENVISION - Study to Characterize Select Objective Metrics & Clinical Outcomes in Chronic Pain Patients With Boston Scientific Neurostimulation Systems
Status: COMPLETED
Conditions: Pain, Chronic
Interventions: DEVICE: Neurostimulation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exchange Transfusion Versus Plasma From Convalescent Patients With Methylene Blue in Patients With COVID-19
Status: UNKNOWN
Conditions: COVID-19
Interventions: BIOLOGICAL: exchange blood transfusion from normal donor|BIOLOGICAL: plasma from convalescent patients with COVID-19|DRUG: Methylene Blue 5 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Neoplasms, Head and Neck
Interventions: DRUG: Dostarlimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-Cancer, Multi-State, Platform Study of Durvalumab (MEDI4736) and Oleclumab (MEDI9447) in Pancreatic Adenocarcinoma, Non-Small Cell Lung Cancer and Squamous Cell Carcinoma of the Head and Neck to Correlate Clinical, Molecular and Immunologic Parameters With DNA Methylation
Status: WITHDRAWN
Conditions: Pancreatic Ductal Adenocarcinoma|Non-small Cell Lung Cancer|Squamous Cell Carcinoma of Head and Neck
Interventions: BIOLOGICAL: Durvalumab|BIOLOGICAL: Oleclumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Bortezomib Combined With Fludarabine and Cytarabine Treatment for Mantle Cell Lymphoma
Status: UNKNOWN
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Bortezomib|DRUG: Fludarabine|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploring the Gut-Brain Axis in Ageing and Neurodegeneration
Status: RECRUITING
Conditions: Healthy|Prodromal Alzheimer's Disease|Parkinson Disease|Multiple Sclerosis
Interventions: DIAGNOSTIC_TEST: Magnetic Resonance Imaging|BEHAVIORAL: Neuropsychological protocol|BEHAVIORAL: Eating habits|DIAGNOSTIC_TEST: Microbiome analyses|DIAGNOSTIC_TEST: Inflammatory markers|DIAGNOSTIC_TEST: Alzheimer's Disease biomarkers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Early Metabolic Support as a Potential Solution to Multi-Organ Dysfunction Syndrome (MODS) During Severe Sepsis
Status: WITHDRAWN
Conditions: Septic Shock
Interventions: DIETARY_SUPPLEMENT: Liquid Nutrition|PROCEDURE: Insulin Drip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Probiotics in Girls With Spina Bifida
Status: WITHDRAWN
Conditions: Urinary Tract Infection
Interventions: DIETARY_SUPPLEMENT: Urex-cap-5 (2x10^9 cfu each of Lactobacillus reuteri RC-14 and Lactobacillus rhamnosus GR-1)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis
Status: COMPLETED
Conditions: Anterior Uveitis
Interventions: DRUG: 40 mg/mL Dexamethasone phosphate ophthalmic solution|DRUG: Prednisolone Acetate (1%) Eyedrops|DRUG: 100 mM sodium citrate buffer solution|DRUG: Placebo Eyedrops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Non-delayed Weight Bearing After Total Hip Replacement With Non-Cemented Fiber Metal Taper Stem
Status: COMPLETED
Conditions: Osteoarthritis|Pain
Interventions: BEHAVIORAL: Patient may be able to put weight on the operated leg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adaptation of a Digital Weight Loss Intervention Promoting Self-regulation for Use in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Overweight and Obesity
Interventions: BEHAVIORAL: Behavioral weight loss with digital tools
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Working Memory Training for Chronic Neuropathic and Fibromyalgia Pain
Status: COMPLETED
Conditions: Working Memory Deficits|Neuropathic Pain|Fibromyalgia
Interventions: BEHAVIORAL: Working Memory Training|BEHAVIORAL: Internet use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aortic Stenosis and PhosphodiEsterase iNhibition With Aortic Valve Replacement (ASPEN-AVR): A Pilot Study
Status: TERMINATED
Conditions: Aortic Stenosis
Interventions: DRUG: Tadalafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Single and Multiple Doses of LP-003 in Healthy Adult Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Spontaneous Urticaria
Interventions: BIOLOGICAL: LP-003 Dose 1 (Single)|BIOLOGICAL: LP-003 Dose 2 (Single)|BIOLOGICAL: LP-003 Dose 3 (Single)|BIOLOGICAL: LP-003 Dose 4 (Single)|BIOLOGICAL: LP-003 Dose 5 (Single)|BIOLOGICAL: Placebo (Single)|BIOLOGICAL: LP-003 Dose 6 (Multiple)|BIOLOGICAL: LP-003 Dose 7 (Multiple)|BIOLOGICAL: LP-003 Dose 8 (Multiple)|BIOLOGICAL: Placebo (Multiple)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib Study of Oral Selinexor in Adult Patients With Relapsed/Refractory B-cell Lymphoma Receiving R-DHAOx or R-GDP
Status: COMPLETED
Conditions: B-cell Lymphoma
Interventions: DRUG: selinexor|DRUG: Rituximab|DRUG: Dexamethasone|DRUG: Oxaliplatin|DRUG: Cisplatin|DRUG: Cytarabine|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Compare the Efficacy Between 3 Fetal Monitoring Methods
Status: UNKNOWN
Conditions: Fetal Heartbeat Tracings
Interventions: DEVICE: Scalp electrode, fetal doppler and EUM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Obesity, Inflammation and Aging: Effects of Physical Exercise and Omega-3 Fatty Acids.
Status: COMPLETED
Conditions: Obesity|Aging|Inflammation
Interventions: DIETARY_SUPPLEMENT: Omega-3 (DHA-rich dietary supplement)|DIETARY_SUPPLEMENT: Placebo (olive oil)|OTHER: Resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of HB0017 in Patients With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: BIOLOGICAL: HB0017 150mg or matching placebo|BIOLOGICAL: HB0017 300mg or matching placebo|BIOLOGICAL: HB0017 450mg or matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preemer Trial - Prophylactic Mesh Versus no Mesh in the Midline Emergency Laparotomy Closure for Prevention of Incisional Hernia: a Multi Center, Double-blind, Randomized Controlled Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Incisional Hernia|Emergency Laparotomy|Midline Laparotomy|Hernia Prevention
Interventions: DEVICE: Prophylactic self gripping mesh|DEVICE: Slowly absorbable continuous monofilament suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tezacitabine and Oxaliplatin for the Treatment of Patients With Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Neoplasms
Interventions: DRUG: tezacitabine|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Mental Ability Challenge Study in Adults With and Without HIV
Status: COMPLETED
Conditions: HIV-1-infection|Aging, Premature|Cognitive Impairment|Memory Impairment|HIV-Associated Cognitive Motor Complex
Interventions: DRUG: Scopolamine Injectable Product|DRUG: Mecamylamine Pill
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: LYT-200 Alone and in Combination With Chemotherapy or Tislelizumab in Patients With Locally Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Metastatic Cancer|Solid Tumor|Pancreatic Cancer|Urothelial Carcinoma|Head and Neck Cancer|Colorectal Cancer
Interventions: DRUG: LYT-200|DRUG: Tislelizumab|DRUG: Gemcitabine/nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palonosetron in Sarcoma Patients Receiving Chemotherapy With Adriamycin and Ifosfamide (AI)
Status: COMPLETED
Conditions: Sarcoma|Nausea|Vomiting
Interventions: DRUG: Palonosetron - Single Dose|DRUG: Palonosetron - Triple Dose|DRUG: Adriamycin|DRUG: Ifosfamide chemotherapy (AI)|DRUG: Zinecard|DRUG: Mesna|DRUG: Vincristine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bortezomib and Combination Chemotherapy in Treating Younger Patients With Recurrent, Refractory, or Secondary Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Childhood Acute Basophilic Leukemia|Childhood Acute Eosinophilic Leukemia|Childhood Acute Erythroleukemia (M6)|Childhood Acute Megakaryocytic Leukemia (M7)|Childhood Acute Minimally Differentiated Myeloid Leukemia (M0)|Childhood Acute Monoblastic Leukemia (M5a)|Childhood Acute Monocytic Leukemia (M5b)|Childhood Acute Myeloblastic Leukemia With Maturation (M2)|Childhood Acute Myeloblastic Leukemia Without Maturation (M1)|Childhood Acute Myelomonocytic Leukemia (M4)|Recurrent Adult Acute Myeloid Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia
Interventions: DRUG: idarubicin|DRUG: cytarabine|DRUG: bortezomib|DRUG: etoposide|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety and Efficacy of a Probiotic on Gastrointestinal Health in Healthy Adults
Status: UNKNOWN
Conditions: Gastrointestinal Health|Healthy
Interventions: DIETARY_SUPPLEMENT: Lactobacillus plantarum 276|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Program of Digital Accompaniment to Optimize Homework Performances and Increase Familial Quality of Life in 9 to 16 Years Children With ADHD
Status: ACTIVE_NOT_RECRUITING
Conditions: ADHD
Interventions: OTHER: Pandah Application smartphone only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Aldosterone & Sodium Regulation in Postural Tachycardia Syndrome - Screening
Status: ACTIVE_NOT_RECRUITING
Conditions: Postural Tachycardia Syndrome
Interventions: OTHER: Autonomic Function Testing|OTHER: Posture Study|PROCEDURE: Measurement of Total Blood Volume|OTHER: Exercise Capacity Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Phase 3 Open-label Study to Evaluate the Safety of MEDI3250 in Healthy Japanese Children Age 2 Years Through 6 Years
Status: COMPLETED
Conditions: Healthy Japanese Children Age 2 Years Through 6 Years
Interventions: DRUG: MEDI3250
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Omega-3 Fatty Acid Supplementation on Hypertriglyceridemia in HIV-infected Children
Status: TERMINATED
Conditions: Hypertriglyceridemia
Interventions: DRUG: Omega Pure followed by placebo|DRUG: Placebo followed by Omega Pure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Nootropic on the Cognitive Performance in Young Adults
Status: COMPLETED
Conditions: Cognitive Change
Interventions: DIETARY_SUPPLEMENT: Nootropic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Single Ascending Dose Tolerability Study of DG3173
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DG3173|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spectroscopic MRI-Guided Radiation Therapy Planning in Glioblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma|Gliosarcoma
Interventions: RADIATION: Dose-Escalated Radiation Therapy|PROCEDURE: Spectroscopic Magnetic Resonance Imaging|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AMG 811 in Subjects With Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: AMG 811|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Emotion in Virtual Reality on Behavior of Children and Young Adults
Status: TERMINATED
Conditions: Healthy Volunteers
Interventions: BEHAVIORAL: manipulation of the level of realism|BEHAVIORAL: manipulation of the presence and size of avatar|BEHAVIORAL: manipulation of interaction|BEHAVIORAL: manipulation of the nature of stimulus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Intravenous Pantoprazole and Famotidine for Stress Ulcer Prophylaxis
Status: TERMINATED
Conditions: Stomach Ulcer
Interventions: DRUG: pantoprazole 40 mg iv|DRUG: famotidine 20 mg iv
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety & Efficacy Study of AT-101 in Combination w/ Rituximab in Previously Untreated Grade I-II Follicular Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Follicular Lymphoma
Interventions: DRUG: AT-101|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HIP Fracture REhabilitation Programme
Status: COMPLETED
Conditions: Hip Fractures
Interventions: OTHER: HIP-REP|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of How Caregivers Help Patients Cope With Respiratory and Other Symptoms Caused by Lung Cancer
Status: UNKNOWN
Conditions: Anxiety Disorder|Depression|Dyspnea|Fatigue|Lung Cancer
Interventions: OTHER: educational intervention|OTHER: informational intervention|OTHER: psychosocial support for caregiver|OTHER: questionnaire administration|PROCEDURE: dyspnea management|PROCEDURE: management of therapy complications
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Flovent Discus vs QVAR vs Pulmicort Flexhaler on Short Term Growth
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone, Budesonide, Beclomethasone|DRUG: Fluticasone, Beclomethasone, Budesonide|DRUG: Budesonide, Fluticasone, Beclomethasone|DRUG: Budesonide, Beclomethasone, Fluticasone|DRUG: Beclomethasone, Fluticasone, Budesonide|DRUG: Beclomethasone, Budesonide, Fluticasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deoxycholic Acid Injection for the Treatment of Superficial Lipomas
Status: COMPLETED
Conditions: Lipoma
Interventions: DRUG: Deoxycholic Acid Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: a Lifestyle Intervention Programme Using Mobile Application vs Booklet for Adults With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: OTHER: App group|OTHER: Booklet group|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of a Modified Banxia Xiexin Decoction for the "Wei-Pi" Syndrome (Postprandial Distress Syndrome)
Status: COMPLETED
Conditions: Postprandial Distress Syndrome
Interventions: OTHER: Banxie Xiexin Decoction (BXD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Spectroscopy of Breast Tissue Through a Needle Device
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: biologic sample preservation procedure|OTHER: immunohistochemistry staining method|OTHER: light microscopy|OTHER: medical chart review|PROCEDURE: histopathologic examination|PROCEDURE: needle biopsy|PROCEDURE: spectroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fasting Mimicking Diet for Reducing Immune Related Adverse Events for Cancer Patients on Immune Checkpoint Inhibitors, FMD-ICI Trial
Status: RECRUITING
Conditions: Lung Non-Small Cell Carcinoma|Lung Small Cell Carcinoma|Malignant Solid Neoplasm|Melanoma|Renal Cell Carcinoma|Urothelial Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Dietary Intervention|OTHER: Educational Intervention|OTHER: Electronic Health Record Review|OTHER: Interview|OTHER: Nutritional Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioequivalence Study of Tipranavir Stored at Controlled Temperature Compared With Tipranavir Stored at Controlled Refrigerated Conditions, Orally Co-administered With Ritonavir in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: TPV - Room condition|DRUG: TPV - Refrigerated conditions|DRUG: Ritonavir (RTV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection of the Emergence of RAS (Rat Sarcoma Viral Oncogene Homolog) Mutations in Circulating DNA (Deoxyribonucleic Acid) in Patients With mCRC (Metastatic Colorectal Cancer) During Treatment With Anti-EGFR (Epidermal Growth Factor Receptor) Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DEVICE: Intplex test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Eplerenone and Aliskiren Research Targeting Hypertensive Patients With Left Ventricular Hypertrophy
Status: UNKNOWN
Conditions: Hypertensive Left Ventricular Hypertrophy
Interventions: DRUG: Aliskiren|DRUG: Eplerenone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of SBRT as Treatment for Oligometastases in Prostate Cancer
Status: COMPLETED
Conditions: Oligometastatic Prostate Cancer
Interventions: RADIATION: Stereotactic Body Radiation Therapy for Oligometastases
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pericapsular Nerve Group Block Chemical Neurolysis in Advanced Hip Osteoarthritis
Status: RECRUITING
Conditions: Osteoarthritis|Osteoarthritis, Hip
Interventions: DRUG: 0.9%sodium chloride|DRUG: 95% ethanol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Extended Release Niacin/Laropiprant on Lipids (0524A-067)
Status: COMPLETED
Conditions: Primary Hypercholesterolemia|Mixed Dyslipidemia
Interventions: DRUG: Comparator: simvastatin|DRUG: niacin (+) laropiprant|DRUG: Comparator: atorvastatin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamics and Arteriovenous Differences of Naloxone in Healthy Participants Exposed to an Opioid
Status: COMPLETED
Conditions: Drug Overdose
Interventions: DRUG: Intravenous naloxone|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intravitreal Faricimab in Diabetic Macular Edema With Limited Response to Aflibercept
Status: NOT_YET_RECRUITING
Conditions: Diabetic Macular Edema
Interventions: DRUG: FARICIMAB 6 Mg in 0.05 mL INTRAVITREAL INJECTION, SOLUTION [VABYSMO]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparable Study of Different Thoracic Radiotherapy Regimens for Extensive Stage Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Carcinoma, Small Cell|Lung Neoplasms
Interventions: RADIATION: high-dose TRT|RADIATION: standard-dose TRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thalidomide and Tegafur/Uracil(UFUR) in the Treatment of Advanced Colorectal Cancer
Status: UNKNOWN
Conditions: Colon Cancer
Interventions: DRUG: THALIDOMIDE and UFUR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coronary Computed Tomography AngioGraphy Prior to Catheter Ablation in Patients With Atrial FIBrillation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DIAGNOSTIC_TEST: Analysis of coronary CT Angiography and CAC scoring at the time of catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men to Test if Different Formulations of BI 764198 With or Without Food Influence the Amount of BI 764198 in the Blood
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 764198 - Formula A|DRUG: BI 764198 - Formula B|DRUG: BI 764198 - Formula C|DRUG: BI 764198 - Formula D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testimonials and Navigation in Rheumatology
Status: NOT_YET_RECRUITING
Conditions: Rheumatologic Disease|Autoimmune Diseases
Interventions: BEHAVIORAL: Video comprised of AIRD patient narratives on COVID-19 vaccination thoughts and experiences|BEHAVIORAL: Video on the importance of good oral health for patients with AIRD|BEHAVIORAL: Brochure on COVID-19 vaccination in AIRD patients|BEHAVIORAL: Patient Navigation|BEHAVIORAL: Brochure on the importance of good oral health in AIRD patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Investigate the Efficacy, Safety and Tolerability of Nexagon® as a Topical Treatment for Subjects With Venous Leg Ulcers
Status: COMPLETED
Conditions: Venous Leg Ulcers
Interventions: DRUG: Nexagon® Low Dose|DRUG: Nexagon® High Dose|DRUG: Nexagon® Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of 'Nexpowder' for Hemostatic Treatments of Nonvariceal, Upper Gastrointestinal Bleeding
Status: COMPLETED
Conditions: Nonvariceal Upper Gastrointestinal Bleeding
Interventions: DEVICE: Nexpowder (Hemostatic powder)|DEVICE: Conventional Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy and Chronic Pain Self-Management Within the Context of Opioid Reduction: The EMPOWER Study
Status: COMPLETED
Conditions: Chronic Pain
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Chronic Pain Self Management Program|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases
Status: COMPLETED
Conditions: Life Threatening Diseases
Interventions: DRUG: Imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Mirikizumab (LY3074828) in Participants With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Mirikizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT