pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Radiation Therapy and Paclitaxel, Carboplatin, and Fluorouracil Followed by Esophagectomy in Treating Patients With Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction
Status: COMPLETED
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: DRUG: carboplatin|DRUG: fluorouracil|DRUG: paclitaxel|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Prospective Trail of HIPEC in Recurrent Ovarian Cancer Patients With HRR Mutation
Status: UNKNOWN
Conditions: Ovarian Cancer|Epithelial Ovarian Cancer|Ovarian Cancer, Epithelial|Hyperthermic Intraperitoneal Chemotherapy(HIPEC)|Homologous Recombination Repair Gene Mutation
Interventions: PROCEDURE: CRS+HIPEC|PROCEDURE: CRS alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Avastin in Combination With Temozolomide for Unresectable or Multifocal GBMs and Gliosarcomas
Status: COMPLETED
Conditions: Glioblastoma|Gliosarcoma
Interventions: DRUG: Avastin and Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Heat on Blood and Oxygen Flow Readings Part 2
Status: COMPLETED
Conditions: Healthy|Peripheral Vascular Disease|Vasoconstriction
Interventions: OTHER: Specialized pulse oximetry probe with external heat pack|OTHER: Standard of Care Pulse Oximetry Probe
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Multicenter Study to Evaluate Safety and Efficacy of WC3011 (Estradiol Vaginal Cream) in Postmenopausal Women
Status: COMPLETED
Conditions: Vulvovaginal Atrophy
Interventions: DRUG: Vehicle|DRUG: WC3011 Estradiol Vaginal Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of High-dose Dual Therapy vs Bismuth-containing Quadruple Therapy for Rescue Treatment of Hp Infection
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: High-dose dual therapy (rabeprazole, amoxicillin)|DRUG: Bismuth-containing quadruple therapy (rabeprazole, tripotassium dicitrate bismuthate, metronidazole, tetracycline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Walking Quality and Quantity in Osteoarthritis (IWALQQ-OA)
Status: SUSPENDED
Conditions: Knee Osteoarthritis
Interventions: BEHAVIORAL: MCG|BEHAVIORAL: SCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Neo-Bladder Construct in Non-Neurogenic Overactive Bladder and Urge Predominant Incontinence
Status: WITHDRAWN
Conditions: Overactive Bladder
Interventions: BIOLOGICAL: Autologous neobladder construct
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Performance of Cervical Arthroplasty for the Treatment of Cervical Degenerative Disc Disease
Status: TERMINATED
Conditions: Cervical Degenerative Disc Disease
Interventions: DEVICE: DISCOVER™ Artificial Cervical Disc|DEVICE: ACDF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of "Nicotinamide Mononucleotide" (NMN) on Cardiometabolic Function
Status: COMPLETED
Conditions: Glucose Metabolism Disorders
Interventions: DIETARY_SUPPLEMENT: NMN supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Preoperative S-1/OHP With Radiation Therapy for Low-lying Rectal Carcinoma in Neo-adjuvant Setting
Status: UNKNOWN
Conditions: Rectal Carcinoma
Interventions: DRUG: S-1|DRUG: Oxaliplatin|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Anti-Retroviral Activity of MK-8558 Monotherapy in Anti-Retroviral-Naïve HIV-1 Infected Participants (MK-8558-002)
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: MK-8558
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy, Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Participants With Major Depressive Disorder (MDD)
Status: TERMINATED
Conditions: Major Depressive Disorder (MDD)
Interventions: DRUG: Escitalopram|DRUG: Aripiprazole|DRUG: Blinded capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating Motor Cortex Processing for Pain Modulation
Status: TERMINATED
Conditions: Motor Activity
Interventions: BEHAVIORAL: Motor Learning|BEHAVIORAL: Somatosensory Learning|BEHAVIORAL: Observational Task|BEHAVIORAL: Mental Imagery|DEVICE: transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific Pancreatitis
Status: COMPLETED
Conditions: Pancreatitis, Chronic
Interventions: DRUG: Vitamin D3 (Cholecalciferol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy
Status: COMPLETED
Conditions: Thyroid-associated Ophthalmopathy|Dry Eye Syndrome
Interventions: DRUG: Methylprednisolone|DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Effect Mechanism of Spinal Manipulative Therapy on LDH Analgesia Based on Multimodal MRI
Status: ACTIVE_NOT_RECRUITING
Conditions: Lumbar Disc Herniation
Interventions: PROCEDURE: Spinal Manipulative Therapy|OTHER: Sham Laser Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of Topical ESR-114 in Subjects With Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriatic Plaque
Interventions: DRUG: ESR-114|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acceptability, Feasibility and Effectiveness of a Worksite Intervention to Lower Cardiometabolic Risk in South Africa
Status: UNKNOWN
Conditions: Dietary Intervention|Pre Diabetes|Hypertension
Interventions: BEHAVIORAL: Behavioral and Canteen intervention|OTHER: Canteen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Exploring the Relationship Between Heart Rate Variability (HRV), Training Load, and Exercise Performance
Status: RECRUITING
Conditions: Heart Rate Variability|Exercise
Interventions: OTHER: Force plate assessment|DEVICE: Whoop wrist band
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Physical Activity on Bone Mineralization and Immune System in Very Low Birth Weight Infants
Status: UNKNOWN
Conditions: Osteopenia of Prematurity
Interventions: BEHAVIORAL: passive physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Exenatide Long-Acting Release on Glucose Control and Safety in Subjects With Type 2 Diabetes Mellitus(DURATION - 1)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: exenatide, long acting release|DRUG: exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of the Concentrated Extract of Soy on Coagulation Factors After Menopause
Status: UNKNOWN
Conditions: Menopause
Interventions: DRUG: Isoflavone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Effects of Whey Protein Supplementation After Fasting in Volunteers
Status: RECRUITING
Conditions: Ketosis|Acute-Phase Response|Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: CHO+WP|DIETARY_SUPPLEMENT: CHO|DIETARY_SUPPLEMENT: Fast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Dietary Habit and Weight Loss in Young Adults With Overweight and Obesity: The Healthy Eating for Young Adults (HEYA) Study
Status: RECRUITING
Conditions: Obesity
Interventions: BEHAVIORAL: HEYA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CommunICation of bEnefit Risk Information: an Online Randomised Controlled Trial
Status: COMPLETED
Conditions: Knowledge, Attitudes, Practice|Literacy|Confidence, Self
Interventions: DEVICE: Vitruvian plot|DEVICE: Kilim plot|DEVICE: Summary of findings table
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Rapid Intermittent Correction Compared With Slow Continuous Correction in Patients With Severe Hypernatremia
Status: RECRUITING
Conditions: Hypernatremia
Interventions: DRUG: Dextrose 5% in water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impacts of Aronia on Inflammation and the Gut Microbiome
Status: COMPLETED
Conditions: Metabolic Syndrome|Inflammation|Hypertriglyceridemia|Obesity
Interventions: DIETARY_SUPPLEMENT: Aronia berry juice|OTHER: Sham comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Injection Site Tolerability, Safety, Pharmacokinetics and Pharmacodynamics Study After a Single Dose Subcutaneous Treatment of Alirocumab SAR236553 (REGN727)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: alirocumab SAR236553 (REGN727)|DRUG: alirocumab SAR236553 (REGN727)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A New More Efficient Cycloplegia Scheme
Status: UNKNOWN
Conditions: Refractive Errors
Interventions: DRUG: Cyclopentolate|DRUG: Cyclopentolate+tropicamide+phenylephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis
Status: TERMINATED
Conditions: Osteomyelitis
Interventions: DRUG: Dalbavancin|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Early Low-Calorie Low-Protein Versus Standard Feeding on Outcomes of Ventilated Adults With Shock
Status: COMPLETED
Conditions: Critical Illness|Shock|Mechanical Ventilation|Critical Illness Myopathy|Nosocomial Infection
Interventions: PROCEDURE: low-calorie low-protein|PROCEDURE: standard-calorie/standard-protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Empagliflozin 10 mg Tablets Relative to Jardiance 10 mg
Status: NOT_YET_RECRUITING
Conditions: Healthy Subjects
Interventions: DRUG: Empagliflozin-Test product|DRUG: Empagliflozin-Reference product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Safety, Pharmacodynamics, and Immunogenicity of PXVX0047
Status: TERMINATED
Conditions: Adenoviral Infection
Interventions: BIOLOGICAL: PXVX0047 Vaccine|BIOLOGICAL: Teva Ad4/Ad7 Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Text-Message-Based Depression Prevention for High-Risk Youth in the ED
Status: COMPLETED
Conditions: Depressive Disorder|Violence
Interventions: BEHAVIORAL: iDOVE Intervention (ED+text)|BEHAVIORAL: Control (EUC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cytosine Arabinoside and Mitoxantrone for Patients With Juvenile Myelomonocytic Leukemia Receiving Repeat Stem Cell Transplantation
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: cyclosporine|DRUG: cytarabine|DRUG: filgrastim|DRUG: methotrexate|DRUG: methylprednisolone|DRUG: mitoxantrone hydrochloride|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: umbilical cord blood transplantation|DRUG: Cis-Retinoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiation Therapy in Treating Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: RADIATION: stereotactic body radiation therapy (SBRT)- 45 Gy|RADIATION: stereotactic body radiation therapy (SBRT) - 47.5 Gy|RADIATION: stereotactic body radiation therapy (SBRT) - 50 Gy (Phase 1)|RADIATION: stereotactic body radiation therapy (SBRT) - 50 Gy (Phase 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Transcranial Magnetic Stimulation on Visual Functions of Adult Amblyopia: a Preliminary Study
Status: RECRUITING
Conditions: Amblyopia
Interventions: DEVICE: Theta burst transcranial magnetic stimulation (TBS) procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bolus Versus Continuous Infusion of Meropenem
Status: COMPLETED
Conditions: Antibiotic Resistant Infection|Critical Illness
Interventions: DRUG: Meropenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is 10 Injections of Bladder Botox Less Painful Than 20 Injections?
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: OnabotulinumtoxinA 100 Units
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Real-Life Effectiveness and Safety in Participants With Advanced/Metastatic Renal Cell Carcinoma Starting 1st Line Nivolumab and Ipilimumab Combination Therapy or Nivolumab Monotherapy After Prior Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Navitoclax in Addition to Bendamustine and Rituximab in Patients With Relapsed Diffuse Large B-Cell Lymphoma (NAVIGATE)
Status: WITHDRAWN
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: bendamustine|DRUG: navitoclax|DRUG: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Lumber Core Stability Exercises on Chronic Non-specific Neck Pain
Status: RECRUITING
Conditions: Neck Pain
Interventions: OTHER: Advices|OTHER: Cervical and Scapular Stabilization Exercises|OTHER: Lumber Core Stability Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sequencing-based Counting of Plasma Epstein-Barr Virus DNA in Non-metastatic Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma|Herpesvirus 4, Human
Interventions: DIAGNOSTIC_TEST: EBV-DNA next generation sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of the Continuous Midwifery Care Model on Birth Outcomes
Status: RECRUITING
Conditions: Birth, First|Pregnancy Related|Newborn; Fit|Trauma, Psychological|Birth Trauma
Interventions: OTHER: The midwife-led continuous care model (MLCC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sublingual vs IV Atropine Bioavailability Study
Status: COMPLETED
Conditions: Toxic Effect of Organophosphate and Carbamate Insecticides
Interventions: DRUG: Atropine Sulfate Ophthalmic Solution|DRUG: Atropine Sulphate Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic-Pharmacodynamic Interaction Between Four Different Single Doses of BIA 3-202 and a Single Dose of Levodopa/Carbidopa (100/25 mg)
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: BIA 3-202|DRUG: Placebo|DRUG: Sinemet 25/100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effect of Erector Spinae Plane Block for Renal Colic Pain
Status: COMPLETED
Conditions: Renal Colic
Interventions: DRUG: 30 ml %0.25 bupivacaine|DRUG: Dexketoprofen-trometamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety of Molnupiravir (EIDD-2801) and Its Effect on Viral Shedding of SARS-CoV-2 (END-COVID)
Status: COMPLETED
Conditions: SARS-CoV 2
Interventions: DRUG: EIDD-2801|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Fatty Acid Supplementation to Enhance Performance
Status: COMPLETED
Conditions: Strength|Body Composition|Muscle Soreness
Interventions: DIETARY_SUPPLEMENT: Omega-3 fatty acid|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Safety & Effectiveness Study of the Hydrus Microstent for Lowering IOP in Glaucoma Patients Undergoing Cataract Surgery (HORIZON)
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma
Interventions: DEVICE: Hydrus Aqueous Implant|PROCEDURE: Cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post Market Study for FloShield 10mm Reusable Cannula and Blunt Obturator and Robotic FloShield
Status: TERMINATED
Conditions: Cholecystectomy|Benign Hysterectomy|Salingo-oophorectomy
Interventions: DEVICE: Cannula and Blunt Obturator
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Needle Knife Fistulotomy Versus Partial Ampullary Endoscopic Mucosal Resection for Difficult Biliary Cannulation
Status: COMPLETED
Conditions: Biliary Disease|Common Bile Duct Calculi|Biliary Stricture|Malignant Hepatobiliary Neoplasm|Pancreatic Disease
Interventions: PROCEDURE: PA-EMR|PROCEDURE: NKF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Proposed Biosimilar Pertuzumab (PERT-IJS) Versus EU-Perjeta® Along With Trastuzumab and Chemotherapy (Carboplatin and Docetaxel) as Neoadjuvant Treatment in Chemotherapy naïve Patients With Early Stage or Locally Advanced HR Negative and HER2 Positive Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: HR Negative HER2 Positive Early Breast Cancer or Locally Advanced Breast Cancer Patients
Interventions: BIOLOGICAL: PERT-IJS plus trastuzumab, carboplatin and docetaxel|BIOLOGICAL: Perjeta plus trastuzumab, carboplatin and docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Arterial Disease Multifactorial Intervention Trial (ADMIT)
Status: COMPLETED
Conditions: Arterial Occlusive Diseases|Cardiovascular Diseases|Heart Diseases|Vascular Diseases|Diabetes Mellitus
Interventions: DRUG: niacin|DRUG: pravastatin|DRUG: beta-carotene|DRUG: vitamin E|BEHAVIORAL: dietary supplements|DRUG: vitamin C|DRUG: warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of PSMA-targeted 18F-DCFPyL PET/CT in the Evaluation of Patients With Renal Cell Carcinoma
Status: COMPLETED
Conditions: Renal Cell Carcinoma|Kidney Cancer
Interventions: DRUG: 18F-DCFPyL|PROCEDURE: PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Alpha tACS
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: NeuroConn Plus Stimulator tACS|OTHER: NeuroConn Plus Stimulator Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Perceptual Deficits in Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: BEHAVIORAL: Sensory Information Processing Training|BEHAVIORAL: Active Control Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The DAPA-MEMRI Trial
Status: RECRUITING
Conditions: Heart Failure|Diabetic Cardiomyopathies
Interventions: DRUG: Dapagliflozin 10 milligrams [Farxiga]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Ranibizumab for the Management of Recurrent Nosebleeds in Patients With Hereditary Hemorrhagic Telangiectasia (HHT)
Status: WITHDRAWN
Conditions: Hereditary Hemorrhagic Telangiectasia (HHT)|Nosebleeds
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CTC in Predicting Neoadjuvant Chemotherapy Among LABC Patients: a Single-center, Prospective, Exploratory Clinical Trial
Status: COMPLETED
Conditions: Locally Advanced Breast Cancer|Circulating Tumor Cell
Interventions: DEVICE: GILUPI CellCollector®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of Linperlisib Plus Chidamide for R/R Cutaneous T-cell Lymphoma: a Prospective, Single-center Study
Status: RECRUITING
Conditions: Cutaneous T-cell Lymphoma
Interventions: DRUG: Linperlisib in combined with Chidamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Pulsatile Intravenous Insulin Delivery on Hypoglycemic Unawareness
Status: WITHDRAWN
Conditions: Hypoglycemia
Interventions: PROCEDURE: Pulsatile Intravenous Insulin Therapy (Humulin R, Novolog)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Etanercept for the Prevention of Complications Resulting From Hematopoietic Stem Cell Transplantation (HSCT)
Status: COMPLETED
Conditions: Graft-Versus-Host Disease
Interventions: DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine in Patients After Intracranial Surgery
Status: COMPLETED
Conditions: Central Nervous System Diseases
Interventions: DRUG: Dexmedetomidine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Style 410 Silicone-Filled Breast Implant Study
Status: COMPLETED
Conditions: Breast Augmentation|Breast Reconstruction|Revision of Augmentation or Reconstruction
Interventions: DEVICE: Style 410 Silicone-Filled Breast Implants
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Masupirdine for the Treatment of Agitation in Dementia of the Alzheimer's Type
Status: RECRUITING
Conditions: Agitation|Alzheimer's Type Dementia
Interventions: DRUG: Masupirdine 50 mg|DRUG: Masupirdine 100 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Buccal Infiltration Technique Compared to Inferior Alveolar Technique
Status: UNKNOWN
Conditions: Local Anesthetic Complication
Interventions: OTHER: Buccal infiltration technique|OTHER: Inferior alveolar nerve block technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy of Microneedling and Topical Methotrexate Versus Microneedling and Topical 5-flourouracil in Treatment of Vitillgo Patients
Status: UNKNOWN
Conditions: Vitiligo
Interventions: DEVICE: derma pen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ramelteon Prevention of Delirium - RCT
Status: UNKNOWN
Conditions: Delirium
Interventions: DRUG: ramelteon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lidocaine Patch for Postoperative Analgesia After Laparoscopic Cholecystectomy
Status: UNKNOWN
Conditions: Postoperative, Pain
Interventions: OTHER: placebo patch applied|OTHER: 5% lidocaine patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of a New Radiotracer (68Ga-NOTA-AE105) for Diagnosing Aggressive Cancer With Positron Emission Tomography
Status: COMPLETED
Conditions: Breast Cancer|Prostate Cancer|Urinary Bladder Cancer
Interventions: DRUG: Injection of 68Ga-NOTA-AE105|DEVICE: Positron Emission Tomography scans
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Long vs. Short Acting Anesthesia for Improving Pain Management After Breast Biopsy
Status: WITHDRAWN
Conditions: Pain Management After Breast Biopsy
Interventions: DRUG: Lidocaine Ropivacaine|DRUG: Lidocaine alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy Plus Interferon Alfa or Rituximab in Treating Patients With Stage III or Stage IV Lymphoma
Status: WITHDRAWN
Conditions: Lymphoma
Interventions: BIOLOGICAL: recombinant interferon alfa|BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: prednisone|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Program Based on the Family-Centered Empowerment Model on Total Knee Prosthesis Patients and Their Caregivers
Status: RECRUITING
Conditions: Caregiver
Interventions: BEHAVIORAL: family-centered empowerment program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pegfilgrastim (Neulasta) for Stem Cell Mobilization in Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Pegfilgrastim (Neulasta)|PROCEDURE: Apheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of MK-6072 and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-002)
Status: COMPLETED
Conditions: Clostridium Difficile Infection
Interventions: BIOLOGICAL: MK-6072|BIOLOGICAL: MK-3415A|BIOLOGICAL: Placebo|DRUG: SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Sirolimus in Treatment of Microcystic , Mixed Lymphatic and Vascular Malformations
Status: RECRUITING
Conditions: Microcystic Lymphatic Malformation|Combined Vascular Malformation|Vascular Malformations
Interventions: DRUG: Sirolimus 1Mg Oral Tablet
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SIT LESS 2: Effect of Sitting Less on Glucose Regulation in People With Diabetes Mellitus Type 2
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Physical activity intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Curvature, Mobility, and Low Back Pain Relationship in Women With and Without Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: DEVICE: Spinal Mouse® measurement|BEHAVIORAL: Low back pain intensity measurement|BEHAVIORAL: Urogenital symptoms measurement|BEHAVIORAL: Disability caused by low back pain
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Patient Reported Outcomes of a "Tailored" Bilio-Pancreatic Limb Length on Daily Food Choices in Mini-Gastric Bypass
Status: COMPLETED
Conditions: Obesity|Morbid Obesity|Bariatric Surgery Candidate|Food Selection|Diet Habit
Interventions: OTHER: Mini-Gastric Bypass
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of the Efficacy and Mechanisms for MBCT and CT for Multiple Sclerosis (MS) Chronic Pain
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Mindfulness Based Cognitive Therapy|BEHAVIORAL: Cognitive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fats And Carbohydrates Quality on Postprandial glycemIc Response in Type 1 Diabetes
Status: UNKNOWN
Conditions: Type 1 Diabetes
Interventions: OTHER: Low fat- Low glycemic index meal|OTHER: MUFA- Low glycemic index meal|OTHER: SAFA- Low glycemic index meal|OTHER: Low fat- High glycemic index meal|OTHER: MUFA- High glycemic index meal|OTHER: SAFA- High glycemic index meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Duration of Enzalutamide and ADT With Metastasis Directed Therapy in Oligometastatic Cancer of the Prostate (DIRECT)
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Prostate Cancer
Interventions: DRUG: Enzalutamide|OTHER: Standard of Care SBRT and ADT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Chemoradiation With VMAT-SIB in Rectal Cancer
Status: COMPLETED
Conditions: Rectal Neoplasms
Interventions: RADIATION: VMAT-SIB|DRUG: XELOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Pharmacokinetics of BLU-5937 Extended Release Prototypes and a BLU-5937 Immediate Release Reference Formulation
Status: COMPLETED
Conditions: Cough|Healthy
Interventions: DRUG: BLU-5937 IR|DRUG: BLU-5937 ER
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ridaforolimus in Treatment of Sarcoma-SUCCEED (Sarcoma Multi-Center Clinical Evaluation of the Efficacy of Ridaforolimus)(8669-011 AM6)
Status: COMPLETED
Conditions: Metastatic Soft-Tissue Sarcomas|Metastatic Bone Sarcomas
Interventions: DRUG: ridaforolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Magrolimab (Hu5F9-G4) in Combination With Avelumab in Solid Tumor Participants and Checkpoint-Inhibitor-Naive Ovarian Cancer Participants Who Progress Within 6 Months of Prior Platinum Chemotherapy
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Magrolimab|DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Compare Preoperative Chemoradiation and Surgery Versus Surgery Alone in Squamous Cell Carcinoma of Oesophagus
Status: UNKNOWN
Conditions: Esophageal Neoplasms
Interventions: PROCEDURE: Esophagectomy|PROCEDURE: Neoadjuvant chemoradiation followed by surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nanoliposomal Irinotecan, Oxaliplatin Plus Capecitabine as Conversion Therapy of Locally Advanced Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: Nanoliposomal Irinotecan, Oxaliplatin plus Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Eptinezumab in Participants With Migraine and Medication Overuse Headache
Status: ACTIVE_NOT_RECRUITING
Conditions: Migraine|Medication Overuse Headache
Interventions: DRUG: Eptinezumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Dare to Move: Treatment of Movement Phobia in Patient With Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: BEHAVIORAL: Arm 2: CBGT-ISE|BEHAVIORAL: Arm 1: CBGT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Everolimus (RAD001) in Children and Adults With Neurofibromatosis Type 2
Status: COMPLETED
Conditions: Neurofibromatosis Type II
Interventions: DRUG: Everolimus (RAD001) , Afinitor®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regulation of Energy Balance and Metabolism - Mechanisms Behind and Beyond Obesity and Weight Loss
Status: COMPLETED
Conditions: Obesity|Appetitive Behavior
Interventions: PROCEDURE: SURG|BEHAVIORAL: DIET|BEHAVIORAL: HAES
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Cilostazol on Endothelial Progenitor Cells and Endothelial Function in Coronary Artery Disease
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Cilostazol|DRUG: Dummy Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brief Motivational Enhancement Therapy for Concurrent Disorders
Status: TERMINATED
Conditions: Psychosis|Substance Use
Interventions: BEHAVIORAL: Brief Motivational Enhancement Therapy|OTHER: treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Edoxaban for Prevention of Blood Vessels Being Blocked by Clots (Thrombotic Events) in Children at Risk Because of Cardiac Disease
Status: COMPLETED
Conditions: Cardiac Disease
Interventions: DRUG: Edoxaban|DRUG: Standard of Care (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pectoral Nerves Block to Relieve Post-sternotomy Pain After Cardiac Surgery
Status: WITHDRAWN
Conditions: Pain, Postoperative|Cardiac Surgery
Interventions: PROCEDURE: PECS2 block|DRUG: Ropivacaine 0.5% Injectable Solution|DRUG: Lidocaine Epinephrine|DRUG: Dexmedetomidine 0.004 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Assess the Efficacy and Toxicity of Induction and Consolidation With CPX-351 for Patients Aged 60 to 75 Years With Secondary or High-risk Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Newly Diagnosed Secondary or High Risk AML
Interventions: DRUG: CPX-351
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Social Support Program on Grief of Pregnancy Loss in Sunpasitthiprasong Hospital
Status: ACTIVE_NOT_RECRUITING
Conditions: Pregnancy Loss|Grief|Social Support
Interventions: OTHER: social support program|OTHER: Routine nursing care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Study of Mindfulness Based Cognitive Therapy and Obsessive-Compulsive Disorder
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: BEHAVIORAL: Mindfulness-based Cognitive Therapy|BEHAVIORAL: Psycho-education Program|DRUG: sertraline, fluvoxamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: iTBS Study for Depression in Patients With Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis|Depression, Anxiety
Interventions: DEVICE: intermittent theta burst stimulation using a MagPro X100|DEVICE: sham intermittent theta burst stimulation using a MagPro X100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bendamustine Bridge to Autologous or Allogeneic Transplant for Relapsed/Refractory Lymphoma
Status: COMPLETED
Conditions: Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma
Interventions: DRUG: Bendamustine|DRUG: Carmustine|DRUG: Etoposide|DRUG: Melphalan|DRUG: Cytarabine|DRUG: Alemtuzumab|BIOLOGICAL: Autologous Stem Cell Transplantation|BIOLOGICAL: Allogeneic Stem Cell Transplantation|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sugammadex Improves Muscle Function After Standard Neuromuscular Recovery
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: DRUG: Sugammadex|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Reflexology on Postpartum Pain, Fatigue, Sleep Quality and Lactation
Status: COMPLETED
Conditions: Breast Feeding|Fatigue|Sleep|Pain, Postoperative
Interventions: OTHER: foot reflexology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment in Healthy Volunteers of the Analgesic Effect Monitored by the NOL Index During Hypnotherapy Session
Status: COMPLETED
Conditions: Pain|Hypnosis
Interventions: OTHER: Medical hypnosis group|OTHER: calm wake group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Umbilical & Cord Blood (CB) Derived CAR-Engineered NK Cells for B Lymphoid Malignancies
Status: COMPLETED
Conditions: B-Lymphoid Malignancies|Acute Lymphocytic Leukemia|Chronic Lymphocytic Leukemia|Non-hodgkin Lymphoma
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Mesna|BIOLOGICAL: iC9/CAR.19/IL15-Transduced CB-NK Cells|DRUG: AP1903
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Ranibizumab Versus Its Combination With Dexamethasone in The Treatment of Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Lucentis alone group|DRUG: Lucentis dexamethasone group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor-Derived Cell-free DNA to DETect REjection in Cardiac Transplantation
Status: WITHDRAWN
Conditions: Heart Transplant Failure and Rejection
Interventions: DIAGNOSTIC_TEST: Prospera Transplant Assessment|PROCEDURE: Endomyocardial biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Telehealth Therapy for Chronic Pain: Comparison of In-person vs. Video-administered ACT for Pain
Status: COMPLETED
Conditions: Chronic Pain
Interventions: BEHAVIORAL: In-Person ACT|BEHAVIORAL: Telehealth ACT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Roflumilust in Chronic Rhinosinusitis With Nasal Polyposis.
Status: UNKNOWN
Conditions: Chronic Sinusitis
Interventions: DRUG: Roflumilust|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Venetoclax, Ixazomib Citrate, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma
Status: COMPLETED
Conditions: Recurrent Plasma Cell Myeloma|t(11;14)
Interventions: DRUG: Dexamethasone|DRUG: Ixazomib Citrate|OTHER: Laboratory Biomarker Analysis|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Bioavailability of Lanadelumab (SHP643) Administered Subcutaneously With the Prefilled Syringe and the Autoinjector in Healthy Adult Volunteer Participants.
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: SHP643
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Interactive Effects of Delta-9-Tetrahydrocannabinol and Pregnenolone: Sub-Study I
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Active Dronabinol|DRUG: Active Pregnenolone|DRUG: Placebo Dronabinol|DRUG: Placebo Pregnenolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Understanding How Cognitive Remediation Works
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Chronic Mental Disorder|Major Depression|Bipolar Disorder
Interventions: BEHAVIORAL: The Thinking Skills for Work Program|BEHAVIORAL: The Cognitive Skills for Work Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reduction of Microemboli of Air Using a New Developed Air Trap (EmbolessTM) During Haemodialysis
Status: RECRUITING
Conditions: Hemodialysis Complication|Air Embolism|Extracorporeal Circulation; Complications
Interventions: OTHER: Emboless|OTHER: Standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Efficacy and Safety Study of Fedratinib Compared to Best Available Therapy in Subjects With DIPSS-intermediate or High-risk Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, or Post-essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Myelofibrosis|Post-Polycythemia Vera|Myelofibrosis
Interventions: DRUG: FEDRATINIB|DRUG: Best Available Therapy (BAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization and Modulation of Traumatic Memories in PTSD Patients Using TMS
Status: RECRUITING
Conditions: Post Traumatic Stress Disorder
Interventions: DEVICE: Trans-Cranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT