pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Immune Responses After a Booster Immunisation With IXIARO® in Elderly Compared to Young Individuals.
Status: UNKNOWN
Conditions: Japanese Encephalitis Vaccine
Interventions: BIOLOGICAL: IXIARO®- Japanese Encephalitis vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of the Vasomotor Function and Myocardial Flow in Patients Treated With Bioresorbable and Metallic Stents at 1 Year
Status: COMPLETED
Conditions: Stable Angina
Interventions: DEVICE: Bioresorbable vascular scaffold|DEVICE: Everolimus-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Characterisation of Relative Bioavailability With Bioequivalence Assessment of Deferiprone Tablets After Oral Single Dose Administration
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Deferiprone 500Mg Tablet|DRUG: Deferiprone 500 MG Oral Tablet [Ferriprox]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: The Phase Ⅱ/Ⅲ Trial of LYB001
Status: NOT_YET_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: LYB001|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose Finding Study Depigoid Phleum: 4 Doses in Patients With Allergic Rhinitis/Rhinoconjunctivitis +-Asthma
Status: COMPLETED
Conditions: Allergic Rhinitis/Rhinoconjunctivitis +- Intermittent Asthma|Sensitization Against Phleum Pratense Pollen|Dose-Finding Study
Interventions: BIOLOGICAL: Depigoid Phleum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Brainwave Control of a Wearable Robotic Arm for Rehabilitation and Neurophysiological Study in Cervical Spine Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: OTHER: Brain-Computer Interface control of robotic arms.|DEVICE: MERCURY v2.0 robotic arms
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Comparing the Safety and Efficacy of 0.5% Ivermectin Cream to Placebo in Lice Infested Subjects
Status: COMPLETED
Conditions: Head Lice
Interventions: DRUG: 0.5% Ivermectin Cream|DRUG: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing the Incidence of Incisional Hernia After Stoma Closure Using a Prophylactic Mesh
Status: RECRUITING
Conditions: Incisional Hernia
Interventions: DEVICE: Stoma closure with non-resorbable mesh (ULTRAPRO Advanced Mesh, Ethicon, Johnson & Johnson) in the sublay position|PROCEDURE: Stoma closure without mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Throwing Velocity and Patient Reported Outcomes in Elite Level Handball Players After Completion of Shoulder-Pacemaker Strength Training
Status: COMPLETED
Conditions: Shoulder Dislocation
Interventions: OTHER: Motion-triggered NMES training protocol|OTHER: Non-Motion-triggered NMES training protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Stem Cell Transplantation in Crohn's Disease
Status: RECRUITING
Conditions: Crohn Disease
Interventions: DRUG: Mesna|DRUG: Cyclophosphamide|DRUG: Filgrastim|PROCEDURE: Apheresis catheter placement|PROCEDURE: Leukapheresis|DRUG: Fludarabine|DRUG: Methylprednisolone|DRUG: Diphenhydramine|DRUG: Acetaminophen|DRUG: anti-thymocyte globulin (rabbit)|DRUG: lymphocyte immune globulin|BIOLOGICAL: Peripheral Blood Stem Cell Infusion|DRUG: Cytoxan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Acute Severe 2019-nCoV Pneumonia With Immunoglobulin From Cured Patients
Status: UNKNOWN
Conditions: 2019-nCoV|Immunoglobulin of Cured Patients
Interventions: DRUG: Immunoglobulin of cured patients|DRUG: γ-Globulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Vibration Therapy Induce Higher Than Normal Bone Strains and Strain Rates Than Those Experienced During Habitual Daily Activities
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DEVICE: Strain Gauge|OTHER: Vibration therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: STATIN-VAP STATIN-VAP - STATINs and Ventilator-Associated Pneumonia
Status: TERMINATED
Conditions: Pneumonia
Interventions: DRUG: SIMVASTATIN|DRUG: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Early Efficacy of Radical Prostatectomy for Newly Diagnosed Very High Risk Locally Advanced and Oligometastatic Prostate Cancer
Status: RECRUITING
Conditions: Locally Advanced and Metastatic Prostate Cancer
Interventions: PROCEDURE: Radical prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Extracorporeal Shock Wave Therapy and Pulse Electromagnetic Field Therapy on Lymphoedema
Status: RECRUITING
Conditions: Lymphedema
Interventions: DEVICE: Extracorporeal shock wave therapy|DEVICE: Pulse electromagnetic field therapy|OTHER: Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ureteroscopic Lithotripsy in the Reverse Trendelenburg Position for Upper Ureteral Stones
Status: COMPLETED
Conditions: Ureterolithiasis|Ureter Stone|Ureter Calculi
Interventions: PROCEDURE: Ureteroscopic lithotripsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intermittent Pneumatic Compression of the Foot vs Geko Plus R-2 Neuromuscular Electrostimulation Device in Venous Leg Ulcer Patients
Status: WITHDRAWN
Conditions: Venous Leg Ulcer
Interventions: DEVICE: geko plus R-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Lung Ultrasound to Diagnose Transient Tachypnea of the Newborn (TTN) Versus Respiratory Distress Syndrome (RDS) in Neonates
Status: COMPLETED
Conditions: Transient Tachypnea of the Newborn|TTN|Respiratory Distress Syndrome|RDS
Interventions: OTHER: Respiratory Distress Group|OTHER: Control Group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cetrorelix Pamoate in Patients With Symptomatic Benign Prostatic Hypertrophy (BPH)
Status: COMPLETED
Conditions: Benign Prostatic Hypertrophy
Interventions: DRUG: Cetrorelix 78+78|DRUG: Cetrorelix 78 + Placebo|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Ligelizumab in Adolescents and Adults With Chronic Inducible Urticaria Who Remain Symptomatic Despite Treatment With H1- Antihistamines
Status: TERMINATED
Conditions: Chronic Inducible Urticaria
Interventions: DRUG: Ligelizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double Blind Multicenter Phase II Study of Time to Progression on Fulvestrant in Combination With Erlotinib or Placebo in Hormone Receptor-Positive Metastatic Breast Cancer (MBC) Subjects Who Progressed on First Line Hormonal Therapy
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Fulvestrant|DRUG: erlotinib|DRUG: Fulvestrant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial on the Effect of Sino-implant (II) Use on Condom Use Among Women in Kingston, Jamaica
Status: COMPLETED
Conditions: Women Wanting Contraceptive Implant for Pregnancy Prevention
Interventions: DEVICE: Sino-implant (II)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pyridoxine in Preventing Hand-Foot Syndrome in Patients Who Are Receiving Capecitabine for Advanced Colorectal Cancer or Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer|Colorectal Cancer|Palmar-plantar Erythrodysesthesia
Interventions: DIETARY_SUPPLEMENT: pyridoxine hydrochloride|OTHER: placebo|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Mocetinostat in Selected Patients With Mutations of Acetyltransferase Genes in Relapsed and Refractory Diffuse Large B-Cell Lymphoma and Follicular Lymphoma
Status: TERMINATED
Conditions: Lymphoma|Relapsed and Refractory|Diffuse Large B-Cell Lymphoma and Follicular Lymphoma
Interventions: DRUG: Mocetinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Hyperbaric Prilocaine With Chloroprocaine for Intrathecal Anaesthesia in Day Case Knee Arthroscopy
Status: COMPLETED
Conditions: Knee Arthroscopy|Spinal Anesthesia
Interventions: DRUG: Isobaric 2-chloroprocaine|DRUG: Hyperbaric prilocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: YouScript IMPACT Registry
Status: COMPLETED
Conditions: Adverse Drug Events|Adverse Drug Reactions|Drug Interaction Potentiation|Drug Metabolism, Poor, CYP2D6-RELATED|Drug Metabolism, Poor, CYP2C19-RELATED|Cytochrome P450 Enzyme Deficiency|Cytochrome P450 CYP2D6 Enzyme Deficiency|Cytochrome P450 CYP2C9 Enzyme Deficiency|Cytochrome P450 CYP2C19 Enzyme Deficiency|Cytochrome P450 CYP3A Enzyme Deficiency|Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant|Poor Metabolizer Due to Cytochrome P450 CYP2C19 Variant|Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Manual Therapies With Supervised Exercise Protocol on Pain and Functional Disability in Patients With Knee OA
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Supervised exercise protocol|OTHER: Specified Manual Therapies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Aerobic Interval Training on Cardiovascular Function in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: OTHER: High intensity aerobic interval training|OTHER: Continuous moderate intensity exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Heparin and the Reduction of Thrombosis (HART) Trial
Status: COMPLETED
Conditions: Thrombosis
Interventions: DRUG: Heparin sulfate infusion at 10 units/kg/hour|DRUG: Placebo infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Intranasal Ketoralac for Pain Management (Sprix)
Status: TERMINATED
Conditions: Postoperative Pain Management|Urolithiasis
Interventions: DRUG: Intranasal Ketoralac|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Brain Stimulation and Physical Therapy Study
Status: COMPLETED
Conditions: Fall|Gait, Unsteady|Aging|Accidental Fall
Interventions: OTHER: Real tDCS and Physical Therapy|OTHER: Sham stimulation and Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effects of Horticulture on Anterior Cingulate Cortex Activation in People With Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Physical activity involving exposure to nature: Therapeutic horticulture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: HD-Tdcs and Pharmacological Intervention For Delirium In Critical Patients With COVID-19
Status: COMPLETED
Conditions: COVID-19|Delirium|Critical Illness
Interventions: COMBINATION_PRODUCT: Active HD-tDCS|COMBINATION_PRODUCT: Sham HD-tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous RPR109881 in Male or Female Patients With Advanced Breast Cancer Who no Longer Respond to Anthracycline, Taxane and Capecitabine Treatment
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: XRP9881
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Different Doses of BI 1701963 Alone and Combined With Trametinib in Patients With Different Types of Advanced Cancer (Solid Tumours With KRAS Mutation)
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumors, KRAS Mutation; SOS1
Interventions: DRUG: BI 1701963|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study for Inoperable Non-Metastatic Pancreatic CA (Stage IVA) With Neoadjuvant GTX, and Radiation With Gemzar
Status: COMPLETED
Conditions: Pancreatic Cancer Stage IVA
Interventions: DRUG: Gemcitabine, docetaxel, and capecitabine|RADIATION: Radiation therapy with gemzar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 68Ga-FAPi-46 PET/CT Scan in Imaging Patients With Sarcoma
Status: RECRUITING
Conditions: Metastatic Sarcoma|Recurrent Sarcoma|Sarcoma
Interventions: PROCEDURE: Computed Tomography|DRUG: Gallium Ga 68 FAPi-46|PROCEDURE: Positron Emission Tomography|RADIATION: 18F-FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Novel Method for Retrograde Intrarenal Surgery (RIRS)
Status: UNKNOWN
Conditions: Kidney Stone
Interventions: PROCEDURE: Addition of gentamicin to irrigation fluid during RIRS|PROCEDURE: Only irrigation fluid during RIRS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Camrelizumab Plus Anlotinib in Patients With Recurrent Sporadic MMRd Endometrial Cancer
Status: NOT_YET_RECRUITING
Conditions: Endometrial Cancer
Interventions: DRUG: Anlotinib + Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases
Status: COMPLETED
Conditions: Oral Lichen Planus|Recurrent Aphthous Stomatitis
Interventions: DRUG: NAVS Naphthalan|DRUG: 0.05% Betamethasone dipropionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Single- and Multiple- Ascending Dose and Food Effect Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HRS-7535 in Healthy Subjects
Status: UNKNOWN
Conditions: Healthy Subjects
Interventions: DRUG: HRS-7535|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Autologous Tolerogenic Dendritic Cells for Rheumatoid Arthritis (AutoDECRA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: TolDC|DRUG: Arthroscopy & saline irrigation alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Breath Analysis as an Additional Test for Colorectal Cancer Screening to Reduce the Number of Unnecessary Colonoscopies
Status: COMPLETED
Conditions: Colorectal Cancer|Polyp of Colon|Colorectal Neoplasms
Interventions: DEVICE: AeonoseTM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence Study of Rivaroxaban 10 mg Film-coated Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rivaroxaban 10 mg film-coated tablet|DRUG: Xarelto 10 mg film-coated tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Combination Chemotherapy Followed by Radiation Therapy in Treating Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: BIOLOGICAL: filgrastim|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: methotrexate|DRUG: vincristine sulfate|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Technology Intensified Diabetes Education Study in African Americans
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2|Diabetes Mellitus, Adult-Onset|Diabetes Mellitus, Non-Insulin-Dependent|Diabetes Mellitus, Noninsulin Dependent|Diabetes Mellitus, Type II
Interventions: BEHAVIORAL: Technology Intensified
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Frailty Assessment in Vascular Hot Clinic Setting - Feasibility and Prognostic Value
Status: RECRUITING
Conditions: Frailty|Frail Elderly Syndrome|Surgery
Interventions: DIAGNOSTIC_TEST: Frailty assessment|DIAGNOSTIC_TEST: Frailty assessment|DIAGNOSTIC_TEST: Frailty assessment|DIAGNOSTIC_TEST: Frailty assessment|DIAGNOSTIC_TEST: Frailty assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ursodeoxycholic Acid in the Treatment of Duodenal Adenomas in Familial Adenomatous Polyposis (FAP) Patients
Status: UNKNOWN
Conditions: Adenomatous Polyposis Coli, Familial
Interventions: DRUG: Ursodeoxycholic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Circulating microRNAs and Degenerative Abdominal Aorta Aneurysm
Status: COMPLETED
Conditions: Abdominal Aorta Aneurysm
Interventions: GENETIC: Tissue-library
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Wandering Nerve: Gateway to Boost Alzheimer's Disease Related Cognitive Performance
Status: RECRUITING
Conditions: Aging
Interventions: OTHER: Active transcutaneous vagus nerve stimulation respiratory-gated non-painful electrical stimulation of the auricle for 10 minute sessions|OTHER: Sham transcutaneous vagus nerve stimulation respiratory-gated non-painful electrical stimulation of the auricle for 10 minute sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Short-term Outcomes of Iridoplasty for Persistent Angle Closure Despite Patent Iridotomies
Status: COMPLETED
Conditions: Angle Closure Glaucoma|Glaucoma
Interventions: PROCEDURE: Argon Laser Peripheral Iridoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Bexagliflozin in Subjects With Moderate Hepatic Impairment
Status: COMPLETED
Conditions: Type2 Diabetes Mellitus
Interventions: DRUG: Bexagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inferior Alveolar Nerve Lateralization With Simultaneous Implant Placement Versus the Use of Short Dental Implants
Status: UNKNOWN
Conditions: Primary Stability of the Implants|Marginal Bone Loss
Interventions: PROCEDURE: Using short dental implant|PROCEDURE: Inferior alveolar nerve lateralization with simultaneous implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of NOYA Sirolimus-Eluting Stent to Treat Coronary Artery Disease
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: NOYA CoCr Biodegradable Coating Sirolimus-Eluting Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet Surveys and Their Impact on Adherence for Rosacea
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: brimonidine topical gel 0.33% & survey|DRUG: brimonidine topical gel 0.33% & SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Anterior Orientation vs Posterior Orientation in Per Oral Endoscopic Myotomy POEM for the Treatment of Achalasia
Status: COMPLETED
Conditions: Achalasia
Interventions: PROCEDURE: Per Oral Endoscopic Myotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Magnesium for Shivering in Epidural Lidocaine Deliveries
Status: SUSPENDED
Conditions: Anesthesia
Interventions: DRUG: Magnesium Sulfate|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of HZT-501 in Reducing the Risk of Ibuprofen-associated Ulcers
Status: COMPLETED
Conditions: Peptic Ulcer
Interventions: DRUG: HZT-501|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transcranial Photobiomodulation Therapy for the Treatment of Autistic Traits in Children and Adolescents With ADHD
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism|Attention Deficit Hyperactivity Disorder
Interventions: DEVICE: Transcranial Photobiomodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhanced Coordinated Specialty Care for Early Psychosis
Status: RECRUITING
Conditions: Psychosis|Schizophrenia|Schizoaffective Disorder|Psychosis Nos/Other|Bipolar Disorder
Interventions: BEHAVIORAL: Care Coordination|BEHAVIORAL: Individual Peer Support|BEHAVIORAL: Digital Outreach|BEHAVIORAL: Cognitive Remediation|BEHAVIORAL: Multi-Family Group Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Antibacterial Effect of Chlorhexidine Added to the Preventive Protocol in Adolescent Special Needs
Status: COMPLETED
Conditions: Caries
Interventions: DRUG: Chlorhexidine varnish added to the preventive protocol|BEHAVIORAL: Preventive protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Therapy Using Monopolar Dielectric Radiofrequency Signals on the Symptoms of Myofascial Trigger Points in Patients With Chronic Nonspecific Low Back Pain.
Status: COMPLETED
Conditions: Chronic Pain
Interventions: OTHER: Experimental: monopolar dielectric diathermy|OTHER: Control: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Expressive Emotional Writing on Facilitating Grief Resolution in Adults With Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries|Transverse Myelitis
Interventions: BEHAVIORAL: expressive writing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Impact of Omalizumab on Exercise Capacity, Physical Activity, and Sleep Quality in Participants With Moderate to Severe Allergic Asthma
Status: TERMINATED
Conditions: Moderate-to-severe Allergic Asthma
Interventions: DRUG: Omalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastric Pull up Versus Free Flap Reconstruction for Laryngo-pharyngeal Defects
Status: UNKNOWN
Conditions: Head and Neck Neoplasms|Pharyngectomy|Reconstructive Surgical Procedures
Interventions: PROCEDURE: Gastric Pull Up|PROCEDURE: Free Flap Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib/II Study of AEB071 and MEK162 in Adult Patients With Metastatic Uveal Melanoma
Status: TERMINATED
Conditions: Uveal Melanoma
Interventions: DRUG: AEB071|DRUG: MEK162
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study to Assess Novel Ointment in a Psoriasis Plaque Test
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: AN2728 Ointment, 5%|DRUG: AN2728 Ointment, 2%|DRUG: AN2728 Ointment, 0.5%|DRUG: AN2728 Ointment Vehicle|DRUG: Betnesol®-V Creme, 0.1%|DRUG: Protopic® Ointment, 0.1 %
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vildagliptin/Metformin in T2DM Patients Starting Basal Insulin
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus (T2DM)
Interventions: DRUG: Vildagliptin|DRUG: Metformin|DRUG: sulfonylurea (SU)|DRUG: Basal Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Curcumin in Kidney Transplant Recipients
Status: ACTIVE_NOT_RECRUITING
Conditions: Disorder Related to Renal Transplantation
Interventions: DIETARY_SUPPLEMENT: Curcumin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Acupuncture to Improve Comfort of Children on a Ventilator in the Intensive Care Unit
Status: COMPLETED
Conditions: Agitation
Interventions: DEVICE: acupuncture|DEVICE: sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-Label Steroid Reduction Study of Adalimumab With Methotrexate in Patients With Active Rheumatoid Arthritis
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: adalimumab (up to 9 months exposure)|DRUG: methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Gefitinib With or Without Apatinib in Patients With Advanced Non-squamous Non-Small-Cell Lung Cancer Harboring EGFR Mutations
Status: UNKNOWN
Conditions: EGFR Tyrosine Kinase Inhibitors Plus VEGFR Inhibitors
Interventions: DRUG: Apatinib|DRUG: Gefitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics of ASP2215 in Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Gilteritinib|DRUG: Voriconazole|DRUG: Midazolam|DRUG: Cephalexin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Erector Spinae Plane Block With Thoracic Paravertebral Block for Breast Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Breast Cancer
Interventions: DEVICE: Intravenous morphine patient controlled device|OTHER: Erector Spinae Plane Block|OTHER: Thoracic Paravertebral Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Focused Power Ultrasound Mediated Inferior Perirenal Adipose Tissue Modification Therapy for Essential Hypertension (PARADISE HTN-III)
Status: RECRUITING
Conditions: Hypertension|Blood Pressure|Cardiovascular Diseases
Interventions: DEVICE: focused power ultrasound mediate inferior perirenal adipose tissue modification|DEVICE: Sham-control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Positive End Expiratory Pressure at the Time of Induction in Morbidly Obese Patients
Status: COMPLETED
Conditions: Morbid Obesity
Interventions: OTHER: positive end expiratory pressure (PEEP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Xolair (Omalizumab) for Treatment of Drug-induced Acute Tubulointerstitial Nephritis (AIN)
Status: WITHDRAWN
Conditions: Acute Interstitial Nephritis
Interventions: DRUG: Omalizumab|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Diabetic Osteoporosis With Exercise
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: COMBINATION_PRODUCT: Behavior intervention of uphill exercise|COMBINATION_PRODUCT: Dietary intervention of exercise before the meal|COMBINATION_PRODUCT: Dietary intervention of uphill exercise|COMBINATION_PRODUCT: Dietary intervention of exercise after the meal|COMBINATION_PRODUCT: Behavior intervention of downhill exercise|COMBINATION_PRODUCT: Dietary intervention of exercise before the meal|COMBINATION_PRODUCT: Behavioral intervention of downhill exercise|COMBINATION_PRODUCT: Dietary intervention of exercise after the meal|COMBINATION_PRODUCT: Behavioral intervention of sedentary no-exercise trial|COMBINATION_PRODUCT: Dietary intervention of eating two meals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Safety, Efficacy and Pharmacokinetics of ARQ-151 Cream in Subjects With Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Roflumilast Cream 0.3%|DRUG: Roflumilast Cream 0.15%|DRUG: Vehicle Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immediate Implants With Customized Abutments
Status: ACTIVE_NOT_RECRUITING
Conditions: Edentulous Alveolar Ridge Atrophy
Interventions: DEVICE: Immediate post-extractive Implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Manual Administration of Propofol-remifentanil Versus Dual Closed-loop Using Bispectral Index as the Control Variable
Status: COMPLETED
Conditions: Anesthesia, General
Interventions: DEVICE: Closed-loop anesthesia system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of MENOPUR Liquid and Powder in Women Undergoing Assisted Reproductive Technology (ART)
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: MENOPUR solution for injection in pre-filled pen, 1200 IU/1.92 mL|DRUG: MENOPUR powder and solvent for solution for injection, 75 IU|OTHER: Placebo (for MENOPUR solution for injection in pre-filled pen)|OTHER: Placebo (for MENOPUR powder and solvent for solution for injection)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Assess the Effects of Liraglutide on Gallbladder Emptying in Overweight and Obese Subjects.
Status: COMPLETED
Conditions: Metabolism and Nutrition Disorder|Obesity
Interventions: DRUG: liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Fentanyl Following Intravenous and Oral Routes of Administration in Healthy Volunteers
Status: COMPLETED
Conditions: Biological Availability
Interventions: DRUG: Fentanyl citrate; Naltrexone; Naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of CFTX-1554 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CFTX-1554|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Evaluating Etanercept Plus Methotrexate in Early Rheumatoid Arthritis
Status: COMPLETED
Conditions: Active Rheumatoid Arthritis|Arthritis, Rheumatoid|Rheumatoid Arthritis
Interventions: DRUG: etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Calcium Channels in Vascular Function
Status: COMPLETED
Conditions: Endothelium, Vascular
Interventions: DRUG: Efonidipine|DRUG: Nifedipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant Comprehensive Treatment for Unresectable Esophageal Cancer
Status: RECRUITING
Conditions: Esophagus Cancer
Interventions: COMBINATION_PRODUCT: Tislelizumab (BGB-A317) with chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Combination on Exercise Performance at High Altitude
Status: COMPLETED
Conditions: Acute Mountain Sickness
Interventions: DRUG: ambrisentan and theophylline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Biological Therapy in Treating Patients With Neuroblastoma That Has Not Responded to Previous Treatment
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: BIOLOGICAL: beta-glucan|BIOLOGICAL: monoclonal antibody 3F8|BIOLOGICAL: sargramostim|DRUG: isotretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate PU-AD in Subjects With Amyotrophic Lateral Sclerosis
Status: WITHDRAWN
Conditions: Amyotrophic Lateral Sclerosis (ALS)
Interventions: DRUG: PU-AD|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Proof of Concept Study in Patients With Parkinson's Disease and End-of-dose Motor Fluctuations
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: ODM-101 65mg Carbidopa|DRUG: ODM-101 105mg Carbidopa|DRUG: Stalevo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II of BAX2398/5-FU/Calcium Levofolinate in Pancreatic Cancer
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer
Interventions: BIOLOGICAL: BAX2398 + 5-FU/calcium levofolinate|DRUG: 5-FU/calcium levofolinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Effectiveness of Rectal Misoprostol & Intravenous Tranexamic Acid Reducing Hemorrhage in Myomectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Hemorrhage, Surgical|Myoma;Uterus|Effect of Drug|Postoperative Hemorrhage|Postoperative Complications
Interventions: DRUG: Cytotec 200Mcg Tablet|DRUG: Transamine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Evaluating the Effect of Etoricoxib and Indomethacin in the Treatment of Acute Gout (0663-081)(COMPLETED)
Status: COMPLETED
Conditions: Acute Gout
Interventions: DRUG: MK0663; etoricoxib / Duration of Treatment: 5 Days|DRUG: Comparator: indomethacin 75 mg sustained release capsule / Duration of Treatment: 5 Days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Unilateral Primary Aldosteronism, Mineralocorticoid Antagonists Versus Surgical Treatment
Status: RECRUITING
Conditions: Primary Hyperaldosteronism Due to Adrenal Adenoma
Interventions: PROCEDURE: Unilateral adrenalectomy|DRUG: Medical treatment (eplerenone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Pertuzumab and Erlotinib for Refractory Pancreatic Adenocarcinoma
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: Pertuzumab|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis
Status: RECRUITING
Conditions: Tuberculous Meningitis
Interventions: DRUG: Aspirin|DRUG: Placebo of aspirin|DRUG: WHO TBM treatment|DRUG: Intensified TBM treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation and Confirmation Study of PT-112 in Advanced Solid Tumors in Combination With Avelumab
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: PT-112|BIOLOGICAL: avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identifying Saliva Markers of Patients With Stomach, Colorectal (Including Pre-cancer Polyp) and Pancreatic Cancers
Status: UNKNOWN
Conditions: Gastric Cancer|Colorectal Cancer and Pre-cancer Polyps|Pancreatic Cancer
Interventions: OTHER: Salivary samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: First CRUSH: Piloting the Preliminary Feasibility and Acceptability of the Competence in Romance and Understanding Sexual Health (CRUSH) Curriculum
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism|Autism Spectrum Disorder
Interventions: BEHAVIORAL: Competence in Romance and Understanding Sexual Health (CRUSH)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: To Yield Further Information On The Efficacy And Safety Of Viagra Among Subjects With Arterial Hypertension .
Status: COMPLETED
Conditions: Impotence|Hypertension
Interventions: DRUG: Sildenafil Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Wobenzym® Plus in Healthy, Sportive People After Eccentric Exercise
Status: COMPLETED
Conditions: Muscle Injury|Muscle Soreness|Exercise Induced Muscle Damage
Interventions: DRUG: Wobenzym® plus|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PREMO Study: to Investigate Port REMoval Outcomes
Status: COMPLETED
Conditions: Neoplasms|Cystic Fibrosis
Interventions: OTHER: Evaluation of the catheter function|OTHER: Catheter tip location, thrombus, sleeve and device damage visualization|OTHER: Catheter-related colonization|OTHER: patient-reported outcome measures (PROM) related to the presence of the TIVAD|OTHER: Macroscopic evaluation of the port chamber and catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Role of Probiotics in Preventing Recurrent Urinary Tract Infections in Pregnant Women
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: DIETARY_SUPPLEMENT: Lactobacillus rhamnosus|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sirolimus Eluting ORSIRO Stent Versus Biolimus-eluting NOBORI Stent
Status: UNKNOWN
Conditions: Coronary Artery Disease|Ischemic Heart Disease
Interventions: DEVICE: Drug-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ALT-836 in Combination With Gemcitabine for Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Locally Advanced Malignant Neoplasm|Malignant Solid Tumour
Interventions: BIOLOGICAL: ALT-836 in combination with gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ambulatory Adaptation to Non-Invasive Mechanical Ventilation
Status: COMPLETED
Conditions: Chronic Respiratory Failure
Interventions: PROCEDURE: Ambulatory adaptation to non- invasive mechanical ventilation for 7 days|PROCEDURE: Hospital based adaptation to non- invasive mechanical ventilation for 7 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of STI-3031 (an Anti-PD-L1 Antibody) in Patients With Selected Relapsed/Refractory Malignancies
Status: WITHDRAWN
Conditions: Peripheral T Cell Lymphoma|Diffuse Large B Cell Lymphoma|Biliary Tract Cancer|Extranodal NK T Cell Lymphoma, Nasal
Interventions: BIOLOGICAL: STI-3031
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DAREON™-5: A Study to Test Whether Different Doses of BI 764532 Help People With Small Cell Lung Cancer or Other Neuroendocrine Cancers
Status: RECRUITING
Conditions: Small Cell Lung Carcinoma|Neuroendocrine Neoplasms
Interventions: DRUG: BI 764532, formulation 1|DRUG: BI 764532, formulation 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib and Temsirolimus in Treating Patients With Unresectable or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: sorafenib tosylate|DRUG: temsirolimus|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Clinical Study of the Guidant Microwave Ablation System for the Treatment of PAF in the MIS Procedure
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Microwave Ablation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Effect of Johnstone's Pressure Splint Added to Stretching on the Spasticity in Cerebrovascular Disease.
Status: UNKNOWN
Conditions: Spasticity as Sequela of Stroke
Interventions: OTHER: Johnstone's Pressure Splint|OTHER: Stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability of Once Daily Indacaterol in Chronic Obstructive Pulmonary Disease (COPD) Using Formoterol Twice Daily as Active Control
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Indacaterol|DRUG: Formoterol|DRUG: Placebo to indacaterol|DRUG: Placebo to formoterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT