pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Dexmedetomidine Infusion Effect on Hemodynamic Variables During Craniotomy
Status: COMPLETED
Conditions: Hemodynamic Instability|Supratentorial Neoplasms
Interventions: DRUG: Dexmedetomidine|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose Escalation Study of Hyperbaric Oxygen With Radiation and Chemotherapy to Treat Squamous Cell Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Carcinoma, Squamous Cell|Cancer of the Head and Neck
Interventions: DRUG: Hyperbaric Oxygen Therapy|DRUG: Hyperbaric Oxygen|DRUG: Hyperbaric oxygen|DRUG: Hyperbaric oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of High-Dose Prednisolone (Solu Dacortin®) Treatment on Choroidal and Optic Nerve Head Blood Flow in Humans
Status: COMPLETED
Conditions: Regional Blood Flow|Optic Disk
Interventions: DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on OsseoSpeed™ Implants in Patients Missing 2-5 Teeth in the Posterior Lower Jaw, Restored With Permanent Teeth Attached 6-7 Weeks Later
Status: COMPLETED
Conditions: Jaw, Edentulous, Partially
Interventions: DEVICE: OsseoSpeed™
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Bandaging and Kinesiotaping® in Patients With Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Elastic bandaging|OTHER: Short stretch bandaging|OTHER: Kinesio taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Assess Safety, Tolerability and Pharmacokinetics of BI 443651 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 443651|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotics on Testosterone in Men
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri (L. reuteri)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate NVC-422 for Urinary Catheter Blockage and Encrustation
Status: COMPLETED
Conditions: Urinary Catheter Blockage and Encrustation
Interventions: DRUG: NVC-422, 0.2%|DRUG: Sterile normal saline, 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Comparing Huachansu Plus Thoracic RT Versus RT Alone For ESCC
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Huachansu|RADIATION: thoracic radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Two Different Tourniquet Techniques on Peripheral IV Access Success Rates
Status: COMPLETED
Conditions: Tourniquet
Interventions: DEVICE: disposable elastic tourniquet|DEVICE: blood pressure cuff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Motor Flexibility in Multidirectional Balance Control
Status: WITHDRAWN
Conditions: Falling
Interventions: BEHAVIORAL: Multidirectional Perturbations for Balance Control Assessment (60 perturbations)|BEHAVIORAL: Multidirectional Perturbations for Balance Control Assessment (150 perturbations)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Efficacy and Safety of 300 IR Sublingual Immunotherapy (SLIT) Tablets in Adult Patients With Allergic Grass Pollen Rhinoconjunctivitis
Status: COMPLETED
Conditions: Allergic Rhinitis Due to Grass Pollens
Interventions: DRUG: 300 IR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Adult Male Participants to Assess Absorption, Distribution, Metabolism and Excretion (ADME) of Radiolabeled PF-06865571.
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Oral [14C]PF-06865571|DRUG: Oral PF-06865571|DRUG: IV [14C]PF-06865571
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial of an Adapted STD Screening and Risk Reduction Intervention
Status: COMPLETED
Conditions: Alcohol Use|Drug Use|Diagnostic Self Evaluation|Gonorrhea|Unprotected Sex|Chlamydia|Trichomonas
Interventions: BEHAVIORAL: Project EMPWR|OTHER: Optimized Standard Care (OSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pulmonary Arterial Hypertension Improvement With Nutrition and Exercise (PHINE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Arterial Hypertension|Insulin Resistance
Interventions: BEHAVIORAL: Nutrition and Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: i-MaCHeL Study is a Two-group, Cluster-RCT, Involves 460 Preschool's Child-parent Dyads, to Prevent Childhood Obesity
Status: UNKNOWN
Conditions: Childhood Obesity Prevention
Interventions: BEHAVIORAL: Experimental Group: Interactive Malaysian Childhood Healthy Lifestyle Program (i-MaCHeL)|BEHAVIORAL: Control Group: Standard health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Non-Comparative Study to Assess the Efficacy and Safety of the New Food Supplement FaseMETS
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Daily administration: 2 tablets FaseMETS a day
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluating the Feasibility of Internet-delivered PCIT
Status: COMPLETED
Conditions: Oppositional Defiant Disorder|Conduct Disorder|Disruptive Behavior Disorder Nos
Interventions: BEHAVIORAL: Parent-Child Interaction Therapy (PCIT)|BEHAVIORAL: Internet-delivered PCIT (I-PCIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Meloxicam Versus Mefenamic Acid in Patients With Dysmenorrhea
Status: COMPLETED
Conditions: Dysmenorrhea
Interventions: DRUG: Meloxicam 7.5 mg|DRUG: Meloxicam 15 mg|DRUG: Mefenamic acid 500 mg|DRUG: Placebo matching 7.5 mg meloxicam|DRUG: Placebo matching 15 mg meloxicam|DRUG: Placebo matching 500 mg mefenamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Unravelling the Impact of Diet on Cardiovascular Health in Treated Heterozygous Familial Hypercholesterolemia.
Status: RECRUITING
Conditions: Familial Hypercholesterolemia|Nutrition, Healthy|Cholesterol, Elevated
Interventions: OTHER: Healthy diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Safety Study of Nivolumab With Irinotecan for Small Cell Lung Cancer
Status: TERMINATED
Conditions: Small-cell Lung Cancer|Small Cell Lung Carcinoma
Interventions: DRUG: Nivolumab 10 MG/ML Intravenous Solution [OPDIVO]|DRUG: Irinotecan Injection [Camptosar]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Isoniazid for the Reversion of Interferon Gamma ELISPOT in Tuberculosis (TB) Case Contacts
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: Isoniazid|DRUG: Isoniazid|DRUG: Placebo of Isoniazid tablets 300mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Atock Dry Syrup With Acute Bronchitis Patients
Status: RECRUITING
Conditions: Acute Bronchitis
Interventions: DRUG: Atock Dry Syrup|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Information With Storybook for Pediatric Anesthesia
Status: COMPLETED
Conditions: Animation, Cartoons, Preoperative Care, Anesthesia, Pediatric
Interventions: OTHER: showing cartoons -storybook|OTHER: showing cartoons - standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study of ALV003 in Healthy Adult Volunteers and Subjects With Well-Controlled Celiac Disease Following a Gluten-Containing Meal
Status: COMPLETED
Conditions: Celiac Disease
Interventions: DRUG: ALV003|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of a Probiotic Formulation in Adults With Irritable Bowel Syndrome With Diarrhea (IBS-D)
Status: RECRUITING
Conditions: IBS - Irritable Bowel Syndrome
Interventions: DRUG: Probiotic formulation|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Improving Parent Understanding of Instructions About Asthma Care
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: Pictogram-based asthma action plan|OTHER: AAAAI standard of care written action plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: One Year Results of Switching to Aflibercept for Persistent Diabetic Macular Edema Resistant to Bevacizumab
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Aflibercept Injection [Eylea]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Central Pain Modulatory Effects of Dry-Needling in Patients With Non-Specific Neck Pain
Status: COMPLETED
Conditions: Neck Pain, Posterior|Trapezius Muscle Strain
Interventions: OTHER: Dry needling|OTHER: Sham needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Is the Neosquamous Epithelium "Normal" Following Endoscopic Ablation of Dysplastic Barrett's Esophagus?
Status: COMPLETED
Conditions: Barrett's Esophagus|Intestinal Metaplasia|Gastroesophageal Reflux Disease (GERD)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Effect of RG1662 on Metformin in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: OTHER: Omnipaque 300|DRUG: RG1662|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Pevonedistat and Belinostat in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Acute Myeloid Leukemia|Recurrent Myelodysplastic Syndrome|Refractory Acute Myeloid Leukemia|Refractory Myelodysplastic Syndrome
Interventions: DRUG: Belinostat|DRUG: Pevonedistat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erlotinib Hydrochloride in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery
Status: TERMINATED
Conditions: Intraductal Papillary Mucinous Neoplasm of the Pancreas|Recurrent Pancreatic Cancer|Stage IA Pancreatic Cancer|Stage IB Pancreatic Cancer|Stage IIA Pancreatic Cancer|Stage IIB Pancreatic Cancer|Stage III Pancreatic Cancer
Interventions: DRUG: erlotinib hydrochloride|PROCEDURE: conventional surgery|OTHER: immunohistochemistry staining method|GENETIC: protein expression analysis|PROCEDURE: biopsy|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Efficacy and Safety of Three Test Products and Comparator on Muscular Performance After the Initiation of a Resistance Training Program
Status: COMPLETED
Conditions: Muscle Strength
Interventions: OTHER: Test Product 1|OTHER: Test Product 2|OTHER: Test Product 3|OTHER: Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Developing, Implementing and Evaluating Effective Community-facility Interactions to Improve Blood Availability and Transfusion in Three Distinct County Settings in Kenya
Status: NOT_YET_RECRUITING
Conditions: Blood Transfusion
Interventions: OTHER: Community-Facility Transfusion Committee (CFTC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Adding Certolizumab to Chemotherapy + Nivolumab in People Who Have Lung Cancer That Can Be Treated With Surgery
Status: RECRUITING
Conditions: Lung Cancer|Lung Cancer Stage II|Lung Cancer Stage III
Interventions: DRUG: Cisplatin|DRUG: Pemetrexed|DRUG: Gemcitabine|DRUG: Carboplatin|DRUG: Certolizumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the CHIME Intervention for Improving Early Head Start/Head Start Educator Well-being
Status: RECRUITING
Conditions: Health, Subjective|Work Related Stress|Compassion|Social Skills
Interventions: BEHAVIORAL: Cultivating Healthy Intentional Mindful Educators
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: PSMA Specific [68Ga]-P137 Peptide Probe for PET Imaging in Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: 11C-Choline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparing the Treatment of Alcohol Withdrawal Syndrome Using Gabapentin Versus Lorazepam
Status: COMPLETED
Conditions: Alcohol Withdrawal Syndrome(AWS)
Interventions: DRUG: Gabapentin|DRUG: Lorazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Study of Isavuconazole and Methadone
Status: COMPLETED
Conditions: Pharmacokinetics of Isavuconazole|Pharmacokinetics of Methadone|Healthy Volunteers
Interventions: DRUG: Isavuconazole|DRUG: Methadone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Effectiveness of Therapeutic Alliance and Minimal Intervention for Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: BEHAVIORAL: Positive Therapeutic Alliance|BEHAVIORAL: Usual care|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arthroscopic Treatment Combined With PRP Injection for Refractory Elbow Epicondylitis
Status: ACTIVE_NOT_RECRUITING
Conditions: PRP|Lateral Epicondylitis
Interventions: DRUG: PRP|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Ganciclovir Therapy for Sight- or Life-Threatening Cytomegalovirus Disease in the Immunocompromised Patient
Status: COMPLETED
Conditions: Cytomegalovirus Infections|Cytomegalovirus Retinitis|HIV Infections
Interventions: DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Pharmacokinetics of Oral Controlled-ileal-release Nicotinic Acid (CIR-NA) Compared to Immediate-release Nicotinic Acid and Placebo in Healthy Subjects and Subjects With Prediabetes
Status: RECRUITING
Conditions: Safety Issues|Pharmacokinetic
Interventions: DRUG: controlled-ileal-release nicotinic acid (SAD/ MAD/MD) single- and multiple-ascending dose (SAD/MAD) or multiple dose (MD)|DRUG: immediate-release nicotinic acid (SAD)|DRUG: Placebo controlled-ileal-release nicotinic acid (SAD/MAD)|DRUG: Placebo immediate-release nicotinic acid (SAD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: ContraTRAIN - a Validation Study of Contralateral Training Protocols
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Strength training 3x10RM + no training|OTHER: Strength training 6x10RM + no training|OTHER: 3x10RM + 6x10RM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Safety and Efficacy of ExAblate Subthalomotomy for the Treatment of Parkinson's Disease Motor Features
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: DEVICE: Exablate Subthalamotomy|DEVICE: Sham Exablate Subthalamotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Internal Gastric Banding, New Simple and Costless Weight Loss Procedure
Status: COMPLETED
Conditions: Morbid Obesity
Interventions: PROCEDURE: Laparoscopic internal gastric banding|PROCEDURE: laparoscopic sleeve gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of CNV2197944 Versus Placebo in Patients With Diabetic Peripheral Neuropathy
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathy
Interventions: DRUG: CNV2197944|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RECURRENCE OF ROTATOR CUFF LESION AFTER SURGICAL REPAIR WITH SINGLE-ROW vs DOUBLE-ROW SUTURE BRIDGE TECNIQUE: A COMPARATIVE STUDY
Status: COMPLETED
Conditions: Cuff Injury, Rotator
Interventions: PROCEDURE: rotatori cuff repair
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Hybrid Immunotherapy for Hemophagocytic LymphoHistiocytosis
Status: COMPLETED
Conditions: Hemophagocytic Lymphohistiocytosis
Interventions: DRUG: ATG, rabbit|DRUG: Etoposide|DRUG: Methotrexate|DRUG: hydrocortisone|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Filgrastim in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: docetaxel|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacodynamcis of SELA-070 Nicotine Vaccine in Smokers
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BIOLOGICAL: SELA-070|BIOLOGICAL: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacity of a Standardized Hypnotic Message During the Application of a Qutenza (Capsaicin) 8% Patch
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: QUTENZA®|OTHER: hypnotic message|OTHER: music therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Improving Nutrition in Children Under Two Through Increased Egg Consumption in Burkina Faso
Status: COMPLETED
Conditions: Nutrition
Interventions: BEHAVIORAL: Integrated nutrition and agricultural (INA) trainings|BEHAVIORAL: Ceremonial Gifting of Livestock
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Stretching in Water and on Land for Patients With Ankylosing Spondylitis
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: OTHER: Multidimensional Mobility Exercises|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of STSA-1002 Combined With STSA-1005 in Healthy Subjects
Status: TERMINATED
Conditions: Healthy Subject
Interventions: DRUG: STSA-1002 Injection|DRUG: STSA-1005 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bougie or Stylet In Patients Undergoing Intubation Emergently (BOUGIE)
Status: COMPLETED
Conditions: Acute Respiratory Failure
Interventions: OTHER: Bougie|OTHER: Endotracheal Tube with Stylet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PeriOperative ISchemic Evaluation-2 Pilot
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DRUG: active clonidine|DRUG: active ASA|DRUG: Clonidine Placebo|DRUG: ASA Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Two Regimens of SAR240550/Weekly Paclitaxel and Paclitaxel Alone as Neoadjuvant Therapy in Triple Negative Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer Female
Interventions: DRUG: paclitaxel|DRUG: Iniparib (SAR2405550 -BSI-201)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adaptive Intervention for Adolescents Following Inpatient Psychiatric Care
Status: RECRUITING
Conditions: Suicide|Suicide, Attempted|Suicidal Ideation|Self Harm
Interventions: BEHAVIORAL: MI- Safety Plan|BEHAVIORAL: Texts messages|BEHAVIORAL: Monitoring|BEHAVIORAL: Portal follow-up|BEHAVIORAL: Booster call
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smartphone Based Tele-rehabilitation on Functional Capacity and Sleep Quality Among Coronary Heart Disease Patients.
Status: RECRUITING
Conditions: Coronary Heart Disease
Interventions: OTHER: Smart Phone Based Cardiac Telerehabilitation|OTHER: Center based cardiac Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Boceprevir in Combination With Peginterferon Alfa-2b Plus Ribavirin in Pediatric Subjects With Chronic Hepatitis C Genotype 1 (P08034)
Status: WITHDRAWN
Conditions: Chronic Hepatitis C
Interventions: DRUG: Boceprevir|DRUG: Peginterferon alpha-2b|DRUG: Ribavirin|DRUG: Boceprevir|DRUG: Peginterferon alfa-2b|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Pharmacodynamics of ACP-001 (TransCon PEG hGH)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ACP-001 (TransCon PEG hGH)|DRUG: ACP-001 (TransCon PEG hGH)|DRUG: ACP-001 (TransCon PEG hGH)|DRUG: ACP-001 (TransCon PEG hGH)|DRUG: Placebo|DRUG: Human Growth Hormone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Tolerability of Initial Periodontal Therapy Combined With Human Dental Pulp Stem Cell Injection in the Treatment of Chronic Periodontitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Periodontitis
Interventions: DRUG: Human Dental Pulp Stem Cells|OTHER: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Meta-Iodobenzylguanidine Scintigraphy Imaging in Patients With Heart Failure and Control Subjects Without Cardiovascular Disease
Status: COMPLETED
Conditions: Heart Failure, Congestive
Interventions: DRUG: 123I-mIBG (meta-iodobenzylguanidine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Armodafinil (CEP-10953) in Treatment of Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea Syndrome(OSAHS)
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Hypopnea
Interventions: DRUG: Armodafinil 250 mg/day|DRUG: Armodafinil 150 mg/day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Autogenous Vein Graft Failure in Peripheral Artery Bypass Procedures
Status: COMPLETED
Conditions: Peripheral Vascular Diseases|Arterial Occlusive Diseases|Ischemia|Graft Occlusion, Vascular|Hyperplasia
Interventions: DRUG: CGT003 (E2F Duplex Decoy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Suprazygomatic Nerve Block in Tonsillectomy Patients
Status: NOT_YET_RECRUITING
Conditions: Tonsillectomy
Interventions: PROCEDURE: Suprazygomatic maxillary nerve block using dexmedetomidne and Bupivacaine|PROCEDURE: Suprazygomatic maxillary nerve block using Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Sevoflurane and Propofol on Maximum Muscular Strength, Speed of Contraction and Relaxation
Status: COMPLETED
Conditions: Anesthesia, General|Neuromuscular Transmission Disorders
Interventions: DRUG: Sevoflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Video Education on Skin-to-Skin at the Time of Delivery
Status: COMPLETED
Conditions: Kangaroo Care|Video|Prenatal Education|Skin-to-skin
Interventions: OTHER: "Jumping into Kangaroo Care" - a video created by the Ohio Department of Health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparing Short-term Outcomes After Direct Anterior and SuperPATH Hip Arthroplasty Approaches
Status: UNKNOWN
Conditions: Arthroplasty, Replacement, Hip
Interventions: PROCEDURE: Direct Anterior Approach (DAA)|PROCEDURE: SuperPATH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IV Iron and SGLT2 Inhibitor on Ventricular Function and Myocardial Iron Content in Heart Failure With Iron Deficiency
Status: NOT_YET_RECRUITING
Conditions: Heart Failure, Systolic|Iron Deficiencies
Interventions: DRUG: Iron Carboxymaltose|DRUG: Dapagliflozin 10mg Tab|DRUG: Placebo of Iron Carboxymaltose|DRUG: Placebo of Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nexplanon Removal: Subcutaneous vs. Topical Lidocaine
Status: UNKNOWN
Conditions: Contraception
Interventions: DRUG: Eutectic Lidocaine Prilocaine|DRUG: Subcutaneous Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Octanoic Acid for Treatment of Essential Voice Tremor
Status: COMPLETED
Conditions: Essential Voice Tremor|Vocal Tremor|Voice Tremor|Essential Tremor of Voice
Interventions: DRUG: Octanoic acid|DRUG: Inactive capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-Blind Study to Evaluate the Effect of Femarelle® on Menopausal on Vasomotor Symptoms
Status: UNKNOWN
Conditions: Menopause|Hot Flashes
Interventions: DIETARY_SUPPLEMENT: Femarelle|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cord Blood Natural Killer (NK) Cells in Leukemia/Lymphoma
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Lenalidomide|DRUG: Rituximab|DRUG: Fludarabine|DRUG: Cyclophosphamide|PROCEDURE: NK Cells|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Different Contraceptives on the Immune System of HIV Infected Women in Zambia
Status: COMPLETED
Conditions: HIV|Contraception|HIV Infections
Interventions: DRUG: Depo Provera|DEVICE: Copper T Intrauterine contraception device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Pilot Study of Non-invasive Brain Stimulation to Boost the Efficacy of Psychotherapy in a Community Sample of People Who Drink Alcohol
Status: RECRUITING
Conditions: Alcohol Use Disorder
Interventions: DEVICE: High-density transcranial alternating current stimulation|DEVICE: Sham stimulation|BEHAVIORAL: Motivational interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: A Study of MabThera (Rituximab) in Participants With Rheumatoid Arthritis Who Have Had an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARD) and/or Anti-Tumor Necrosis Factor (Anti-TNF) Therapy.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Rituximab [MabThera/Rituxan]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study Comparing Submerged Versus Trans-mucosal Healing of P.004 Implants in the Anterior Mandible and Maxilla
Status: COMPLETED
Conditions: Jaw, Edentulous, Partially
Interventions: DEVICE: Straumann Bone Level Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Central Corneal Thickness and 24-hour Fluctuation of Intraocular Pressure
Status: COMPLETED
Conditions: Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Latanoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparative Study of Sensitivity of Ga-DOTATOC PET vs Octreoscan SPECT + CT
Status: COMPLETED
Conditions: Adult Medulloblastoma|Childhood Medulloblastoma|Neuroblastoma|Neuroendocrine Tumor|Somatostatinoma
Interventions: DRUG: gallium Ga 68-edotreotide|PROCEDURE: positron emission tomography/computed tomography|RADIATION: indium In 111 pentetreotide|PROCEDURE: computed tomography|PROCEDURE: contrast-enhanced magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: PF-00299804 in Stage IIIB or Stage IV Non-Small Cell Lung Cancer Not Responding to Standard Therapy for Advanced or Metastatic Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: PF-00299804|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Baricitinib in the Treatment of Adults With Pyoderma Gangrenosum (PG)
Status: RECRUITING
Conditions: Pyoderma Gangrenosum|Skin Diseases|Wound Heal|Pyoderma|Skin Ulcer
Interventions: DRUG: Baricitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phlebotomy and Lifestyle and Diet Advices vs Lifestyle and Diet Advices Only in Patients With Dysmetabolic Liversiderosis
Status: COMPLETED
Conditions: Liver Cirrhosis|Iron Overload
Interventions: PROCEDURE: Phlebotomy|BEHAVIORAL: Lifestyle and diet advices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Emergence Agitation is a Problem in Pediatric Anesthesia. We Aim to Lower Its Incidence by Using Dexmedetomidine
Status: RECRUITING
Conditions: Emergence Delirium
Interventions: DRUG: Total Intravenous Dexmedetomidine|DRUG: Inhalation Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study To Establish The Effects Of PF-04457845 On Sleep In Healthy Volunteers
Status: TERMINATED
Conditions: Sleep|Healthy Volunteers
Interventions: DRUG: PF-04457845 / matched placebo|DRUG: PF-04457845 / matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reestablishing Sleep and Circadian Alignment in Medical Intensive Care Unit (MICU) Patients Via a Mechanistic RCT of an Sleep Chronobundle
Status: RECRUITING
Conditions: Critical Illness|Sleep Deprivation|Circadian Rhythm Sleep Disorder, Unspecified
Interventions: OTHER: Chronobundle - light|OTHER: chronobundle - feeding|OTHER: chronobundle - mobility|OTHER: chronobundle - sleep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Safety and Efficacy of Cetrotide® 3 Milligram (mg) Versus Antagon™ in Women Undergoing Ovarian Stimulation
Status: COMPLETED
Conditions: Infertile Women Undergoing Assisted Reproductive Technology (ART)
Interventions: DRUG: Cetrotide®|DRUG: Antagon ™|DRUG: Recombinant human follicle stimulating hormone (r-hFSH)|DRUG: Human Menopausal Gonadotropin (hMG)|DRUG: Recombinant Human Choriogonadotropin (r-hCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Nutritional Supplement in Reducing Surgical Site Infections
Status: TERMINATED
Conditions: Peripheral Vascular Disease|Claudication
Interventions: DIETARY_SUPPLEMENT: Arginine enriched oral nutritional supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Stem Cell Infusion in the Treatment of Patients With Neurological Complications After Ischemic Stroke
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: BIOLOGICAL: UC-MSC infusion via intravenous route|BIOLOGICAL: UC-MSC infusion via intrathecal route|OTHER: standard stroke treatment and rehabilitation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy
Status: RECRUITING
Conditions: Grade 1 Glioma|Mixed Glio-neuronal Tumors|Pleomorphic Xanthoastrocytoma
Interventions: DRUG: Trametinib|DRUG: Vinblastine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epidural Steroids With Intrathecal Nalbuphine for Lower Abdominal Oncologic Surgery
Status: COMPLETED
Conditions: Lower Abdominal Oncologic Surgery
Interventions: DRUG: Placebo-nalbuphine|DRUG: Dexamethasone-nalbuphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: VERxVE Study on Efficacy and Safety of Nevirapine XR in Comparison to Nevirapine IR With Truvada in Naive HIV+ Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: nevirapine IR|DRUG: nevirapine XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Role of Serum ADAM 17 (A Disintegrin And Metalloprotease 17) and Caspase 3 in Patients With Chronic Kidney Disease
Status: NOT_YET_RECRUITING
Conditions: Chronic Kidney Diseases
Interventions: OTHER: caspase 3 and ADAM 17 biomarkers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pioglitazone Versus Metformin as First Treatment in Infertile Women With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Pioglitazone
Interventions: DRUG: Pioglitazone|DRUG: Metformin|DRUG: Clomiphene Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of a Half-dose Bolus of r-SAK Prior to Primary PCI in ST-elevation Myocardial Infarction
Status: RECRUITING
Conditions: ST Elevation Myocardial Infarction
Interventions: DRUG: Recombinant staphylokinase|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Affective Processing in Depression and Epilepsy
Status: TERMINATED
Conditions: Epilepsy|Depression|Healthy
Interventions: OTHER: fMRI|OTHER: Hamilton Depression Rating Scale|OTHER: Beck's Depressive Inventory|OTHER: Interictal Dysphoric Disorder Inventory (IDDI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigating the Effect of Standardized Olive Extract on Bone Turnover Markers in Postmenopausal Women
Status: COMPLETED
Conditions: Osteoporosis|Osteopenia
Interventions: DIETARY_SUPPLEMENT: Standardized Extract of Olive Polyphenols|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study to Assess the Efficacy of IMM-124E (Travelan®) in a Controlled Human Infection Model
Status: ACTIVE_NOT_RECRUITING
Conditions: Diarrhea|Travelers Diarrhea|Infectious Diarrhea
Interventions: BIOLOGICAL: Travelan|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Study of Buparlisib + Docetaxel in Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) Patients
Status: TERMINATED
Conditions: Squamous Non-small Cell Lung Cancer
Interventions: DRUG: Buparlisib|DRUG: Buparlisib matching placebo|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of XL147 (SAR245408) in Combination With Trastuzumab or Paclitaxel and Trastuzumab in Subjects With Metastatic Breast Cancer Who Have Progressed on a Previous Trastuzumab-based Regimen
Status: COMPLETED
Conditions: Breast Cancer|Breast Neoplasms
Interventions: DRUG: XL147 (SAR245408)|BIOLOGICAL: trastuzumab|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Closed Loop Pacemaker Treatment on Recurrent Vasovagal Syncope
Status: COMPLETED
Conditions: Vasovagal Syncope
Interventions: DEVICE: Pacemaker treatment, pacemaker programmed as active = CLS|DEVICE: Pacemaker, programmed as passive = VVI 30 beats per minute (bpm)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare a Dose of Telotristat Etiprate in Subjects With Renal Impairment With Matched Subjects With Normal Renal Function
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Telotristat etiprate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Safety and Effectiveness of the SONICO-CX Intracoronary Electrohydraulic Shockwave Balloon Catheter
Status: UNKNOWN
Conditions: Calcified Atheroma
Interventions: DEVICE: Electrohydraulic shock wave lithotripsy|DEVICE: Rotary atherectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Intra-Arterial and Intra-Tumoral Ad-p53 With Capecitabine (Xeloda) or Anti-PD-1 in Liver Metastases of Solid Tumors and Recurrent Head and Neck Squamous Cell Cancer
Status: TERMINATED
Conditions: Metastatic Solid Tumor Cancer|Recurrent Head and Neck Cancer
Interventions: DRUG: Ad-P53|DRUG: Xeloda|DRUG: Keytruda|DRUG: Opdivo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOcUs on Colorectal CAncer oUtcomes: Long-Term Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer
Interventions: OTHER: Use of a standardized set to collect clinical and patient-centered data, to assess the trend of the Global Health Status overtime in colorectal cancer patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: IMPOWR-ME Project 1: Trial of Yoga and Physical Therapy Onsite at Opioid Treatment Programs
Status: RECRUITING
Conditions: Substance Use Disorders|Chronic Pain|Opioid Use Disorder|Back Pain Lower Back Chronic
Interventions: OTHER: Yoga|OTHER: Physical Therapy|OTHER: Treatment As Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of a Physical Activity Counselling Intervention on Mental Health in Firefighters
Status: UNKNOWN
Conditions: PTSD|Stress, Psychological|Depressive Symptoms|Anxiety Disorders and Symptoms
Interventions: BEHAVIORAL: Physical activity counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Blood Pressure on Renal Function and Oxygenation in Septic Shock
Status: COMPLETED
Conditions: Septic Shock|Acute Kidney Injury
Interventions: OTHER: MAP 60 mmHg|OTHER: MAP 75 mmHg|OTHER: MAP 90 mmHg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Azithromycin for Patients With Chronic Rhinosinusitis Failing Medical and Surgical Therapy
Status: COMPLETED
Conditions: Chronic Rhinosinusitis|High-risk Patient
Interventions: DRUG: Azithromycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laboratory-based Hypnosis Intervention on Pain Responsivity in Adolescents With Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: BEHAVIORAL: Hypnosis|BEHAVIORAL: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of TRS01 in Participants With Post-surgical Ocular Inflammation
Status: COMPLETED
Conditions: Post Surgical Ocular Inflammation
Interventions: DRUG: TRS01 eye drops|DRUG: TRS01 eye drops|DRUG: TRS01 eye drops|DRUG: Placebo eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect Of Dexmedetomidine On Sublingual Microcirculation In Patients Undergoing On Pump CABG Surgery
Status: UNKNOWN
Conditions: Sublingual Microcirculation
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo for Dexmedetomidine normal saline infusion|DRUG: Propofol infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rhythm Effect on Dance Learning in Children With and Without Cerebral Palsy.
Status: RECRUITING
Conditions: Cerebral Palsy (CP)
Interventions: BEHAVIORAL: With regular rhythm|BEHAVIORAL: Without regular rhythm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE