pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Influence of Non-Carious Cervical Lesions on Root Coverage
Status: RECRUITING
Conditions: Gingival Recession
Interventions: PROCEDURE: Root coverage surgery by means of a coronally advanced flap combined with a connective tissue graft|PROCEDURE: Reconstruction of the CEJ with a composite restoration followed by root coverage surgery by means of a coronally advanced flap combined with a connective tissue graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reformative Versus Single Step Dilation Percutaneous Dilatational Tracheostomy
Status: COMPLETED
Conditions: Respiratory Failure|Respiratory Depression
Interventions: PROCEDURE: reformative dilation technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn How Finerenone (BAY94-8862) Moves Into, Through and Out of the Body, How it Affects the Body, and How Safe it is in Adult Participants With Different Degrees of Reduced Liver Function and in Healthy Participants With Similar Age, Weight and Gender Distribution
Status: COMPLETED
Conditions: Worsening Chronic Heart Failure|Diabetic Nephropathy
Interventions: DRUG: Finerenone (BAY94-8862)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Shear- Force at the Skin in Patients With Diabetes Mellitus
Status: UNKNOWN
Conditions: Pressure Ulcer|Diabetes Mellitus Type 2|Charcot- Osteoarthropathy
Interventions: OTHER: Shear- force 19 newton and 3,9 kpa pressure for half an hour
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: To Evaluate the Safety, Tolerability, and Immunogenicity of BNT162b2 Against COVID-19 in Healthy Pregnant Women 18 Years of Age and Older
Status: COMPLETED
Conditions: SARS-CoV-2 Infection|COVID-19|Maternal Immunization
Interventions: BIOLOGICAL: BNT162b2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Proton Versus Photon Radiotherapy for Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: RADIATION: Photon|RADIATION: Proton|RADIATION: Carbon ion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pyodine Soaked Gelfoam vs Single Topical Application of Clotrimazole in Otomycosis Treatment
Status: COMPLETED
Conditions: Otomycosis
Interventions: DRUG: Clotrimazole Cream|DRUG: Povidone-Iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of BEZ235 in Patients With Advanced Solid Malignancies Enriched by Patients With Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Advanced Solid Tumors|Cowden Syndrome
Interventions: DRUG: BEZ235
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reviewing DAA Efficacy Managing Patient Treatment In Online Neighbourhoods
Status: UNKNOWN
Conditions: Hepatitis C
Interventions: DRUG: Sofosbuvir+Ledipasvir|DRUG: Sofosbuvir+Daclatasvir|DRUG: Sofosbuvir+Velpatasvir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ultrasound-guided Blocks for Ambulatory Knee Arthroscopy
Status: COMPLETED
Conditions: Postoperative Pain|Postoperative Nausea and Vomiting|Postoperative Function Level
Interventions: PROCEDURE: Block of the SN and ONP|PROCEDURE: Placebo block|DRUG: Paracetamol|DRUG: Morphine|DRUG: Ondansetron|DRUG: Metoclopramide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma
Status: RECRUITING
Conditions: B Acute Lymphoblastic Leukemia|B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|B Acute Lymphoblastic Leukemia, BCR-ABL1-Like|Lymphoblastic Lymphoma|Mixed Phenotype Acute Leukemia|T Acute Lymphoblastic Leukemia
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Calaspargase Pegol|DIETARY_SUPPLEMENT: Levocarnitine|DRUG: Pegaspargase|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of Ilaprazole 5, 20 and 40 mg QD and Lansoprazole 30 mg QD on Healing of Erosive Esophagitis
Status: COMPLETED
Conditions: Esophagitis
Interventions: DRUG: Ilaprazole|DRUG: Ilaprazole|DRUG: Ilaprazole|DRUG: Lansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics Study of Fixed Dose Combination of DWJ1386 Compared With Co-administration of DWC20155 and DWC20156 in Healthy Subjects
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Co-administration of DWC20155 and DWC20156|DRUG: DWJ1386 Tab.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Selution Sirolimus-eluting Balloon for Internal Pudendal-penile Artery Disease-related Erectile Dysfunction
Status: RECRUITING
Conditions: Erectile Dysfunction|Peripheral Arterial Disease|Arterial Stenosis
Interventions: DEVICE: Selution SLR™ sirolimus-eluting balloon|DEVICE: Plain old balloon angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dietary Fatty Acids Improve Social Impairment in Autism Spectrum Disorders
Status: COMPLETED
Conditions: Autism Spectrum Disorders
Interventions: OTHER: Aravita including arachidonic acid and docosaheaenoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction to Study the Effect of BMS-708163 on Pharmacokinetics (PK) of Galantamine Extended Release (ER)
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: galantamine|DRUG: galantamine|DRUG: BMS-708163
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: The Role of the Adrenergic System in Hypoglycaemia Induced Inflammatory Response in People With Type 1 Diabetes and People Without Type 1 Diabetes-RAID-II
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 1|Inflammation
Interventions: DRUG: hyperinsulinaemic hypoglycaemic clamp|DRUG: Propranolol Hydrochloride 1 MG/ML|DRUG: Phentolamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Vestipitant (GW597599) in the Treatment of Breakthrough Postoperative Nausea and Vomiting (PONV)
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Ondansetron|DRUG: Vestipitant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Respiratory Volume Measure Using ExSpiron 1Xi
Status: COMPLETED
Conditions: ICU(Intensive Care Unit) Patients|Mechanical Ventilation After Surgery
Interventions: DEVICE: Respiratory Volume Monitor(RVM)|DEVICE: artificial respirator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pragmatic Research eXamining Inpatient Symptoms
Status: COMPLETED
Conditions: Postoperative Pain|Nausea|Vomiting|Anxiety|Depression
Interventions: PROCEDURE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: U/S Guided SAPB Versus Conventional IV Analgesics in Postoperative Pain Management in MRM
Status: COMPLETED
Conditions: Injection Site Haematoma|Local Anesthetic Toxicity
Interventions: PROCEDURE: ultrasound guided serratus anterior plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Pre-hospital Ultrasound Guided Peripheral Venous Catheter Insertion
Status: COMPLETED
Conditions: Prehospital
Interventions: PROCEDURE: Full utrasound guidance|PROCEDURE: Partial ultrasound guidance|PROCEDURE: No ultrasound guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of CDP7657 in Patients With Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Immune System Diseases|Autoimmune Diseases|Lupus Erythematosus, Systemic|Skin and Connective Tissue Diseases|Connective Tissue Disease
Interventions: BIOLOGICAL: CDP7657|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose:
Clinical trial: the Clinical Trial of Gefitinib(Non - Small Cell Lung Cancer)
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Gefitinib Tab （CTTQ），First medication；Gefitinib Tab （CTTQ），From the 8th day of trial|DRUG: Gefitinib tablets (Yi Ruisha），First medication|DRUG: Gefitinib Tab 250 MG（CTTQ），From the 8th day of trial.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PECS-2 for Breast Surgery
Status: COMPLETED
Conditions: Breast Neoplasm Female|Regional Anesthesia|Anesthesia|Regional Anesthesia Morbidity|Anesthesia Morbidity
Interventions: DRUG: Ropivacaine 5 mg/ml, 35 ml|DRUG: Remifentanil 50 microg/ml|DRUG: Betamethason 4 mg|DRUG: Paracetamol 1,5 g|DRUG: Propofol|DRUG: Arcoxia, 120 mg|DRUG: Ondansetron 4 mg|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA)
Status: UNKNOWN
Conditions: Periodic Fever
Interventions: DRUG: Canakinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Dapagliflozin+Saxagliptin in Addition to Metformin v/s Saxagliptin or Dapagliflozin in Patients With DM2.
Status: COMPLETED
Conditions: Type2 Diabetes Mellitus
Interventions: DRUG: Dapagliflozin 10mg|DRUG: Saxagliptin 5mg|DRUG: Saxagliptin 5mg + Dapagliflozin 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Refractory Solid Tumors
Status: TERMINATED
Conditions: Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: thiotepa|DRUG: topotecan hydrochloride|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Homebased (6-week) Stretching Intervention in Children With Spastic Cerebral Palsy
Status: RECRUITING
Conditions: Spastic Cerebral Palsy
Interventions: OTHER: Casting of the lower limb and homebased stretching exercise program.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ITI 333 in Healthy Volunteers
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: ITI-333|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Food and Formulation on the Pharmacokinetics, Safety, and Tolerability of GNS561 After One Single Dose (50 and 200mg) in Healthy Volunteers
Status: UNKNOWN
Conditions: Primary Liver Cancer
Interventions: DRUG: GNS561 oral tablets and capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Irinotecan Combined With Cisplatin (IP) Versus Etoposide Combined With Cisplatin (EP) in Advanced and Metastatic Gastrointestinal Pancreatic and Esophageal Neuroendocrine Carcinoma
Status: TERMINATED
Conditions: Neuroendocrine Carcinoma
Interventions: DRUG: irinotecan cisplatin|DRUG: Etoposide cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Optimization and Evaluation of the Extremism and Intolerance Curriculum for the Kingdom of Bahrain.
Status: RECRUITING
Conditions: Norm, Social|Literacy|Resistance Skills|Beliefs About Consequences|Decision Making Skills|Empathy|Tolerance|Open Mindedness|Active Citizenship|Anti-extremism
Interventions: BEHAVIORAL: Peaceful Coexistence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Zoledronic Acid Administration to Metastatic Breast Cancer Patients With Non-symptomatic Bone Lesions
Status: TERMINATED
Conditions: Breast Cancer|Neoplasm Metastasis
Interventions: DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intracerebroventricular Administration of CD19-CAR T Cells (CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T-lymphocytes) for the Treatment of Primary Central Nervous System Lymphoma
Status: RECRUITING
Conditions: Central Nervous System Lymphoma
Interventions: PROCEDURE: Aspiration|PROCEDURE: Biospecimen Collection|PROCEDURE: Catheterization|BIOLOGICAL: CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T-lymphocytes|PROCEDURE: Computed Tomography|DRUG: Cyclophosphamide|DRUG: Fludarabine|PROCEDURE: Leukapheresis|PROCEDURE: Lumbar Puncture|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Endomanometric Laparoscopic Nissen Fundoplication Improves Postoperative Outcomes
Status: COMPLETED
Conditions: GERD
Interventions: PROCEDURE: endomanometric guided LNF|PROCEDURE: laparoscopic Nissen fundoplication alone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 320-detector Computed Tomography to Assess Myocardial Extracellular Volume Fraction in Patients With Atrial Fibrillation Before AF Ablation.
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DIAGNOSTIC_TEST: CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ultrasound-guided Erector Spinae Block Versus Quadratus Lumborum Block for Laparotomies
Status: COMPLETED
Conditions: Analgesia
Interventions: PROCEDURE: erector spinae plane block|PROCEDURE: Quadratus lumborum plane block|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Ascending Dose Study to Investigate the Safety, Tolerability, Immunogenicity and Pharmacokinetics of Intravenously Administered RO7126209 in Healthy Participants
Status: COMPLETED
Conditions: Alzheimers Disease
Interventions: DRUG: RO7126209|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BXOS110 Injection in the Treatment of Acute Ischaemic Stroke
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: high-dose BXOS110|DRUG: low-dose BXOS110|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Laryngeal Mask Airway in Laparoscopic Hernia Repair
Status: RECRUITING
Conditions: Inguinal Hernia|Inguinal Hernia, Indirect|Inguinal Hernia Bilateral|Inguinal Hernia Unilateral
Interventions: DEVICE: Laryngeal Mask Airway|DEVICE: Endotracheal Tube Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety, Tolerability, and Pharmacokinetic of Single Dose of Pitavastatin 4 mg in Severe Renal Patients Versus Healthy Adult Volunteers
Status: COMPLETED
Conditions: Severe Renal Impairment
Interventions: DRUG: Pitavastatin 4mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Fesibility of EUS-guided Gallbladder Drainage With a New-type of Electrocautery LAMS in the Treatment of Malignant Distal Biliary Obstruction
Status: RECRUITING
Conditions: Distal Malignant Biliary Obstruction
Interventions: PROCEDURE: endoscopic biliary drainage
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase II Trial of Weekly Alternating Sequential Administration of BIBF 1120 and BIBW 2992 in Patients With Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: DRUG: BIBF 1120 and BIBW 2992
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Prospective Trial to Evaluate the Safety and Efficacy to Treat Esophageal Cancer Using 5-FU, Oxaliplatin, and Docetaxel
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: FLOT therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ET019003-T Cells in Relapsed/Refractory CD19+ B-Cell Leukemia and Lymphoma
Status: UNKNOWN
Conditions: Leukemia|Lymphoma
Interventions: DRUG: ET019003-T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Combination of Immunotherapy and Stereotactic Ablative Radiotherapy in Oligometastatic Gastrointestinal Cancer
Status: UNKNOWN
Conditions: Oligometastatic Gastrointestinal Cancer
Interventions: RADIATION: Stereotactic Ablative Radiotherapy (SABR)|DRUG: Camrelizumab for injection (200 mg, iv), D1, Q2W, 14-day cycle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Acupuncture for Insomnia in Breast Cancer Patients Undergoing Chemotherapy
Status: COMPLETED
Conditions: Insomnia, Secondary|Breast Cancer Female|Chemotherapy
Interventions: DEVICE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Postpartum Hemorrhage in Patients With Severe Preeclampsia Using Carbetocin Versus Misoprostol
Status: COMPLETED
Conditions: Severe Pre-eclampsia, Postpartum Condition or Complication
Interventions: DRUG: misoprostol|DRUG: carbetocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: ElectroPoration In a Clinical Setting
Status: COMPLETED
Conditions: Tolerance
Interventions: DEVICE: Electroporation with voltage amplitude of 40 V (corresponding to an electric field strength of 100 V/cm)|DEVICE: Electroporation with voltage amplitude of 60 V (corresponding to an electric field strength of 150 V/cm)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pemigatinib in Non-muscle Invasive Bladder Cancer Patients With Recurrent Low- or Intermediate-Risk Tumors
Status: RECRUITING
Conditions: Bladder Cancer|NMIBC|Non-Muscle Invasive Bladder Cancer|Urothelial Carcinoma Recurrent
Interventions: DRUG: Pemigatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Double Layer Application Using a Universal Adhesive in the Quality of Cervical Lesions Restorations
Status: COMPLETED
Conditions: Non-carious Cervical Lesions
Interventions: PROCEDURE: Application of one layer|PROCEDURE: Application of double layer|PROCEDURE: Etch-and-rinse application mode|PROCEDURE: Selective enamel etching application mode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Study of Pharmacokinetics and Safety of Dose of Adefovir Dipivoxil in Children and Adolescents With HBV
Status: COMPLETED
Conditions: Hepatitis B
Interventions: DRUG: Adefovir dipivoxil|DRUG: Adefovir Dipivoxil|DRUG: Adefovir Dipivoxil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Study to Evaluate the Efficacy and Safety of ABT-493/ABT-530 in Renally Impaired Adults With Chronic Hepatitis C Virus Genotype 1 - 6 Infection
Status: COMPLETED
Conditions: Chronic Hepatitis C Virus (HCV) Infection
Interventions: DRUG: ABT-493/ABT-530
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Using the Environmental Exposure Chamber (EEC) to Assess the Onset of Action of Ciclesonide, Applied as a Nasal Spray in Treatment of Seasonal Allergic Rhinitis (BY9010/M1-406)
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal|Hay Fever
Interventions: DRUG: Ciclesonide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of AJU-S56 5% in Dry Eye Syndrome Patients
Status: RECRUITING
Conditions: Dry Eye Syndromes
Interventions: DRUG: AJU-S56 5%|DRUG: Placebo Group(Vehicle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Confirmatory Study of Indacaterol in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Indacaterol 300 µg|DRUG: Salmeterol 50 µg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of Proteoglycan Depletion in Femoroacetabular Impingement With T1ρ Magnetic Resonance Imaging (MRI)
Status: COMPLETED
Conditions: Femoroacetabular Impingement|Cartilage, Articular|Hip Joint|MRI
Interventions: DIAGNOSTIC_TEST: Magnetic Resonance Imaging (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impact of the Obstructive Sleep Apnea Syndrome (OSAS) on the Ventricular Remodeling After Acute Myocardial Infarction
Status: COMPLETED
Conditions: Recent Acute Myocardial Infarction
Interventions: OTHER: Without Obstructive Sleep Apnea (syndrome)|OTHER: Mild or moderate Obstructive Sleep Apnea (syndrome)|OTHER: Severe Obstructive Sleep Apnea (syndrome)|DEVICE: CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: User Performance Evaluation of Contour Plus, Accu-Chek Active, Accu-Chek Performa and OneTouch Select Simple Blood Glucose Monitoring Systems Following ISO 15197:2013
Status: COMPLETED
Conditions: Diabetes
Interventions: DEVICE: Blood glucose monitoring systems for self-testing
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: DIGEST I Drug Coated Balloon for Biliary Stricture
Status: ACTIVE_NOT_RECRUITING
Conditions: Biliary Stricture|Biliary Anastomotic Stenosis|Biliary Obstruction|Biliary Disease
Interventions: DEVICE: GIE Drug Coated Balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of 0.5% vs 0.375% Ropivacaine on Autonomous Nervous System
Status: UNKNOWN
Conditions: Shoulder Surgery|Interscalene Nerve Block|Ropivacaine
Interventions: PROCEDURE: Interscalene nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Does a High BMI Affect Supervised Pelvic Floor Muscle Training for Improving Symptoms in Women With Various Stages of Pelvic Organ Prolapse?
Status: UNKNOWN
Conditions: Pelvic Organ Prolapse|Uterine Prolapse|Anterior Wall; Prolapse, Vaginal|Posterior Wall; Prolapse, Vaginal|Cystocele|Rectocele|Vault Prolapse, Vaginal
Interventions: OTHER: Pelvic Floor Muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis
Status: COMPLETED
Conditions: Toxoplasmosis, Cerebral|HIV Infections
Interventions: DRUG: Sulfadiazine|DRUG: Clarithromycin|DRUG: Atovaquone|DRUG: Pyrimethamine|DRUG: Leucovorin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy of Dexmedetomidine Versus Clonidine to Control Delirium in Patients Undergoing CABG
Status: COMPLETED
Conditions: Delirium on Emergence
Interventions: DRUG: Dexmedetomidine|DRUG: Clonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Autotaxin (ATX) as a Marker for Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DIAGNOSTIC_TEST: Serum Autotaxin|RADIATION: chest x-ray|DIAGNOSTIC_TEST: Breast ultrasound or mammography|DIAGNOSTIC_TEST: Histopathological examination of breast mass specimens|RADIATION: Magnetic Resonance Imaging ( MRI) and Bone scan|DIAGNOSTIC_TEST: Peripheral haemogram|DIAGNOSTIC_TEST: Renal and liver functions|DIAGNOSTIC_TEST: Prothrombin time and concentration|DIAGNOSTIC_TEST: Cancer Antigen 15-3 (CA15-3).|OTHER: Full medical history|OTHER: Full clinical examination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mutation Scores and Differential Protein Evaluating Efficacy in Adjuvant Chemotherapy in HER2(-) Luminal B Breast Cancer
Status: UNKNOWN
Conditions: Susceptibility, Genetic|Chemotherapy Effect
Interventions: DRUG: DT group|DRUG: ET group|DRUG: NX group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Influences of Intervention With Home-based Recovery Activity in Obstructive Sleep Apnea Syndrome
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Tongue Muscle Trainer (TMT)|DEVICE: Threshold Inspiratory Muscle Trainer (TIMT)|PROCEDURE: Walking Exercise|DEVICE: Continuous Positive Airway Pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Azacitidine and Venetoclax as Induction Therapy With Venetoclax Maintenance in the Elderly With AML
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine and Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Pharmacokinetics and Safety/Tolerability of Fimasartan and Linagliptin in Healthy Volunteers
Status: COMPLETED
Conditions: Hypertension|Diabetes
Interventions: DRUG: Treatment A (Fimasartan, Linagliptin)|DRUG: Treatment B (Fimasartan/Linagliptin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Making Decisions About the Measles-Mumps-Rubella Vaccine
Status: COMPLETED
Conditions: Measles|Mumps|Rubella|MMR Vaccination
Interventions: OTHER: Behavioral: Computer-based tailoring system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial of Omacetaxine, Azacitidine, and Growth-Colony Stimulating Factor (G-CSF) for Myelodysplastic Syndromes (MDS)
Status: WITHDRAWN
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Omacetaxine|DRUG: Azacitidine|DRUG: G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Interventions for Expectant Mothers (LIFE-Moms Phoenix) - Phoenix
Status: COMPLETED
Conditions: Obesity|Diet Therapy|Diabetes Type 2
Interventions: BEHAVIORAL: Enhanced standard care|BEHAVIORAL: Intensive lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In the Treatment of Implants With Different Methods; Early Bone Loss and Patient Satisfaction
Status: COMPLETED
Conditions: Dental Implants
Interventions: PROCEDURE: Flapless implant surgery.|PROCEDURE: Conventional implant surgery.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peg Interferon α-2b for Relapsed Hematological Malignancies After Allo-HSCT
Status: COMPLETED
Conditions: Hematological Neoplasms|Recurrence
Interventions: DRUG: Peg interferon alfa-2b
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FLOMAX® Versus Placebo, in Male Patients With Acute Urinary Retention Related to Benign Prostatic Hyperplasia (BPH)
Status: COMPLETED
Conditions: Prostate Hyperplasia
Interventions: DRUG: FLOMAX® capsules|DRUG: Placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Outcomes Using the AMO Advanced Customvue™ iLasik Procedure
Status: COMPLETED
Conditions: Vision Correction
Interventions: PROCEDURE: Advanced CustomVue™ iLASIK procedure|DEVICE: WaveScan WaveFront® System, STAR S4 IR™ Excimer Laser System and IntraLase™ FS System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics, and Pharmacodynamics of BIRT 2584 XX in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIRT 2584 XX|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Lorcaserin in the Treatment of Cocaine Use Disorder
Status: COMPLETED
Conditions: Cocaine-Related Disorders
Interventions: DRUG: Lorcaserin|DRUG: Placebo Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PK Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Patients Undergoing Vitrectomy
Status: COMPLETED
Conditions: Vitrectomy
Interventions: DRUG: Dexamethasone Phosphate Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lap-guided vs Us-guided TAP Block in Pediatric Laparoscopy
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: PROCEDURE: Laparoscopic-guided TAP Block|PROCEDURE: Ultrasound-guided TAP Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cannabinoids, Neural Synchrony, and Information Processing
Status: COMPLETED
Conditions: Cannabis|Psychotic Disorders
Interventions: DRUG: THC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: a2 Milk for Autism and Attention-deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Autism|Attention Deficit Hyperactivity Disorder|Autism Spectrum Disorder
Interventions: DIETARY_SUPPLEMENT: a2 milk|DIETARY_SUPPLEMENT: a1 containing milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Bone Marrow Mononuclear Cell Transplantation for Stroke Patients
Status: COMPLETED
Conditions: Cerebral Embolism|Stroke
Interventions: BIOLOGICAL: autologous bone marrow mononuclear cells|BIOLOGICAL: autologous bone marrow mononuclear cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase IIb Safety and Efficacy Study of BAY94-8862 in Subjects With Worsening Chronic Heart Failure and Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Moderate Chronic Kidney Disease Alone
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: BAY94-8862|DRUG: Eplerenone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Precision Nutrition to Improve Cardiometabolic Health With Dietary (Poly)Phenols
Status: RECRUITING
Conditions: Individual Variability in (Poly)Phenol Metabolism|Cardiometabolic Health|Personalized Dietary Intervention|Obesity
Interventions: OTHER: Personalized Dietary Plan|DIETARY_SUPPLEMENT: Oral (Poly)phenol Challenge Test (OPCT)|OTHER: General Dietary Advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: CS DNA MVA Trial in Mampong, Ghana
Status: WITHDRAWN
Conditions: Plasmodium Falciparum Malaria
Interventions: BIOLOGICAL: MVA-CSO Vaccine|BIOLOGICAL: PfCSP DNA (VCL-2510) Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Multilevel Approach to Connecting Underrepresented Populations to Clinical Trials
Status: NOT_YET_RECRUITING
Conditions: Cancer
Interventions: BEHAVIORAL: Stand-alone Research Portal|BEHAVIORAL: Portal with Virtual Community Health Educator (vCHE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Lot-to-lot Consistency of Quadrivalent Influenza Vaccine (Split Virion), Inactivated
Status: COMPLETED
Conditions: Seasonal Influenza
Interventions: BIOLOGICAL: Quadrivalent Influenza Vaccine (Split Virion), inactivated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Use of Bevacizumab in Trabeculectomy Surgery
Status: COMPLETED
Conditions: Glaucoma|Optic Neuropathy|Fibrosis
Interventions: DRUG: Bevacizumab|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Nicotine Replacement Therapy and D-cycloserine on Nicotine Treatment Seekers
Status: WITHDRAWN
Conditions: Cigarette Smoking
Interventions: DRUG: D-cycloserine|DRUG: Nicotine Replacement Therapy (patch)|BEHAVIORAL: Smoking Cue Exposure|BEHAVIORAL: Progressive Muscle Relaxation|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of Four Different Oral Tablet Formulations of Lazertinib (JNJ-73841937) in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lazertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Additive Anti-inflammatory Action for Critically Ill Patients With Cardiovascular Surgery (Xuebijing) IV
Status: UNKNOWN
Conditions: Cardiovascular Disease|Aortic Dissection|Coronary Artery Disease|Valve Heart Disease|Congenital Heart Disease|Critical Illness
Interventions: DRUG: XueBiJing Injection|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture in Treating Hot Flashes in Patients With Prostate Cancer
Status: TERMINATED
Conditions: Fatigue|Hot Flashes|Prostate Cancer
Interventions: PROCEDURE: acupuncture therapy|PROCEDURE: fatigue assessment and management|PROCEDURE: hot flashes attenuation|PROCEDURE: management of therapy complications|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Impact of a Single Dexmedetomidine Bolus on Intraoperative Sevoflurane Consumption (DEXHALE)
Status: RECRUITING
Conditions: Inhalation Anesthesia|Dexmedetomidine|Sevoflurane|Laparoscopy
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of an Emergency Department-based Intervention to Reduce Alcohol Misuse in Older Adults
Status: COMPLETED
Conditions: Alcohol Abuse
Interventions: BEHAVIORAL: Brief Negotiated Interview|BEHAVIORAL: General Health Information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy, Safety and Tolerability of TSUPPORT for Adults With Tourette Syndrome
Status: UNKNOWN
Conditions: Tourette Syndrome
Interventions: DIETARY_SUPPLEMENT: TSupport (a Traditional Chinese Medicine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Safety and Efficacy of ASC41 in Overweight and Obese Subjects
Status: COMPLETED
Conditions: Overweight and Obesity|NAFLD|Hyperlipidemia
Interventions: DRUG: ASC 41|DRUG: ASC 41 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Amifostine in Treating Young Patients With Liver Cancer
Status: COMPLETED
Conditions: Childhood Hepatoblastoma|Recurrent Childhood Liver Cancer|Stage I Childhood Liver Cancer
Interventions: PROCEDURE: therapeutic conventional surgery|DRUG: cisplatin|DRUG: vincristine sulfate|DRUG: fluorouracil|DRUG: amifostine trihydrate|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Progression of Carotid Artery Atheroma in Moderately Hypercholesterolemic Subjects
Status: COMPLETED
Conditions: Carotid Artery Stenosis|Hypercholesterolemia
Interventions: DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Tepotinib Combined With Cetuximab in Participants With Left-Sided RAS/BRAF Wild Type Metastatic Colorectal Cancer (PERSPECTIVE)
Status: TERMINATED
Conditions: Colorectal Neoplasms
Interventions: DRUG: Tepotinib|BIOLOGICAL: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Concurrent Chemoradiotherapy for Locally Advanced Gastroesophageal Junction or Upper Gastric Adenocarcinoma
Status: UNKNOWN
Conditions: Gastroesophageal Junction Adenocarcinoma
Interventions: RADIATION: Preoperative concurrent chemoradiotherapy|PROCEDURE: Radical D2 total gastrectomy|DRUG: Adjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention to Enhance PrEP Uptake and Adherence in a Community-Based Setting
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV)
Interventions: BEHAVIORAL: Sexual Health Counseling|BEHAVIORAL: Enhanced Adherence Intervention|BEHAVIORAL: PrEP Information (Active Control)|BEHAVIORAL: Standard of Care Adherence Support (Active Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Liposomal Doxorubicin and Daunorubicin-containing VDCLD Regimen in the Treatment of Adult ALL Patients
Status: UNKNOWN
Conditions: Adult Acute Lymphoblastic Leukemia
Interventions: DRUG: PLD|DRUG: DNR
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Closed-loop Control of Overnight Glucose Levels (Artificial Pancreas) in Children With Type 1 Diabetes in a Diabetes Camp
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: Single-hormone closed-loop strategy|DEVICE: Dual-hormone closed-loop strategy|DEVICE: Insulin pump therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maintaining ERBB Blockade in EGFR-mutated Lung Cancer
Status: TERMINATED
Conditions: Non-small-cell Lung Cancer With Somatic EGFR Mutations
Interventions: DRUG: Afatinib|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate in Treating Patients With Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Childhood Chronic Myelogenous Leukemia|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Chronic Phase Chronic Myelogenous Leukemia
Interventions: DRUG: imatinib mesylate|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BP-C1 in Short-term Treatment of Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: BP-C1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Whole-Body Hyperthermia for Mood and Anxiety Disorders
Status: NOT_YET_RECRUITING
Conditions: Postpartum Depression|Mood Disorders|Anxiety Disorders|Postpartum Anxiety
Interventions: OTHER: Whole-Body Hyperthermia|DIAGNOSTIC_TEST: fMRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hypofractionated vs Conventional Fractionated RT in Soft Tissue Sarcomas
Status: RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: RADIATION: Conventional Fractionated|RADIATION: Hypofractionated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Safety of the Anti-Cancer Drugs Durvalumab and Olaparib During Radiation Therapy for Locally Advanced Unresectable Pancreatic Cancer
Status: RECRUITING
Conditions: Locally Advanced Pancreatic Carcinoma|Stage II Pancreatic Cancer AJCC v8|Stage III Pancreatic Cancer AJCC v8|Unresectable Pancreatic Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|BIOLOGICAL: Durvalumab|DRUG: Olaparib|RADIATION: Radiation Therapy|PROCEDURE: Radiologic Examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Anti-Pneumococcal Vaccines in HIV-Infected Pregnant Women
Status: COMPLETED
Conditions: PNC Vaccine|HIV-infected Pregnant Women
Interventions: BIOLOGICAL: PPV-23|BIOLOGICAL: PCV-10|OTHER: NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: GPC3/Mesothelin-CAR-γδT Cells Against Cancers
Status: RECRUITING
Conditions: Pancreas Cancer|Lung Cancer|Liver Cancer|Mesothelioma|CAR-T Cell Therapy|Solid Tumor, Adult
Interventions: BIOLOGICAL: Cell therapy for solid tumors
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing Insulin Degludec/Liraglutide, Insulin Degludec, and Liraglutide in Chinese Subjects With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetic Drugs (OADs)
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin degludec/liraglutide|DRUG: Insulin degludec|DRUG: Liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT