pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety of Intraseasonal Specific Immunotherapy With Depiquick® Birch
Status: COMPLETED
Conditions: Allergic Rhinoconjunctivitis
Interventions: DRUG: Depiquick Birch (DPG103)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cranberry for Prevention of Urinary Tract Infections in Multiple Sclerosis Patients
Status: COMPLETED
Conditions: Multiple Sclerosis|Urinary Tract Infections|Bladder Dysfunction
Interventions: DRUG: Cranberry|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Safety and Efficacy of L19TNF Plus Lomustine in Patients With Glioblastoma at First Progression
Status: RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: L19TNF|DRUG: Lomustine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endocare for Pelvic-perineal Pain Related to Endometriosis Used at Home
Status: UNKNOWN
Conditions: Endometriosis|Chronic Pain|Pelvic Pain
Interventions: DEVICE: Endocare|DEVICE: Digital control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Nivolumab Following Partially Human Leukocyte Antigen (HLA) Mismatched BMT in Children & Adults With Sarcoma
Status: RECRUITING
Conditions: Sarcoma|Solid Tumor, Adult|Solid Tumor, Childhood
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Intravenous Infusion of Human Placenta-Derived Cells (PDA001) for the Treatment of Adults With Stage II or III Pulmonary Sarcoidosis
Status: TERMINATED
Conditions: Stage 2 Pulmonary Sarcoidosis|Stage 3 Pulmonary Sarcoidosis
Interventions: BIOLOGICAL: PDA001 (cenplacel-L)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Circulatory Changes During Venovenous (VV)- and Venoarterial (VA) Extracorporeal Membrane Oxygenation (ECMO)
Status: UNKNOWN
Conditions: Pulmonary Hypertension of the Newborn (PPHN)
Interventions: OTHER: echocardiography Doppler sonography, blood and urine sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of ACTR087 in Combination With SEA-BCMA in Subjects With Relapsed or Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma|Multiple Myeloma in Relapse|Refractory Multiple Myeloma
Interventions: BIOLOGICAL: ACTR087|BIOLOGICAL: SEA-BCMA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chloridehexidine Versus Povidine Jodine Both Soluted in Alcohol in Forefoot Surgery
Status: COMPLETED
Conditions: Hallux Valgus|Arthritis of the First Metatarsophalangeal Joint
Interventions: PROCEDURE: skin preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluating a Health Literacy Intervention to Improve Colorectal Cancer Screening in Underserved Areas
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer Screening
Interventions: BEHAVIORAL: Health literacy intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluate Safety and Immunogenicity of a Booster Dose of Pneumococcal Conjugate Vaccine in Preterm Born Infants.
Status: COMPLETED
Conditions: Infections, Streptococcal|Streptococcus Pneumoniae Vaccines
Interventions: BIOLOGICAL: GSK Biologicals´ Pneumococcal Conjugate Vaccine (GSK1024850A)|BIOLOGICAL: Infanrix™-IPV/Hib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety Study of EF-022 ( Modified Vitamin D Binding Protein Macrophage Activator) in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: EF-022 (Modified Vitamin D Binding Protein Macrophage Activator)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Sulphonylurea Synergy With DPP4 Inhibitors
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Sulfonylurea|DRUG: DPP4 Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Antibiotic Prophylaxis in High-Risk Arthroplasty Patients
Status: ENROLLING_BY_INVITATION
Conditions: Infections Joint Prosthetic|Overweight or Obesity|MSSA Colonization|MRSA|Chronic Kidney Diseases|Diabetes|Autoimmune Diseases|Inflammatory Disease|Tobacco Use
Interventions: DRUG: Cephalexin|DRUG: Doxycycline|DRUG: Cefadroxil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: First in Human (FIH) Study of ALN-SOD in Adult Participants With Amyotrophic Lateral Sclerosis Associated With Mutation in the SOD1 Gene (SOD1-ALS)
Status: NOT_YET_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis (ALS)|Mutation in the Superoxide Dismutase-1 (SOD1) Gene
Interventions: DRUG: ALN-SOD|OTHER: Diluent|DRUG: Placebo (PB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study to Assess the Loss of HbsAg After a 48-week Treatment Period With Pegylated Interferon Alpha 2a in Patients With Chronic Hepatitis B
Status: UNKNOWN
Conditions: Chronic Hepatitis B|AgHbs Negativation
Interventions: DRUG: Pegylated interferon-alpha-2a|DRUG: Nucleotidic or Nucleosidic Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of 2 Intensification Treatment Strategies for Neuroblastoma Patients With a Poor Response to Induction
Status: TERMINATED
Conditions: Very High Risk Neuroblastoma
Interventions: RADIATION: mIBG|DRUG: Topotecan|DRUG: Thiotepa|PROCEDURE: Autologous stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In Favor of My Resilient Self- Effects of an Academic Course on the Emotional Resilience of Students.
Status: UNKNOWN
Conditions: Preventive Therapy
Interventions: BEHAVIORAL: "In Favor of My Resilient Self" Academic course
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Partially-guided Protocol for Maxillary Overdentures Retained by Ti-Zr One-piece Mini Implants
Status: NOT_YET_RECRUITING
Conditions: Edentulous Jaw|Implant Complication
Interventions: PROCEDURE: Implant placement surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Asparaginase Activity Monitoring (AAM) in Adult Patients With Acute Lymphoblastic Leukemia (ALL)
Status: TERMINATED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Asparaginase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Rituximab and Bevacizumab in Patients With Follicular Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Follicular
Interventions: DRUG: Bevacizumab|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-expandable, Fully Covered Metal Stents in Biliary Strictures Due to Chronic Pancreatitis
Status: COMPLETED
Conditions: Benign Biliary Strictures|Chronic Pancreatitis
Interventions: DEVICE: FC Nitinol SEMS (Niti-S, TaeWoong Medical Co., Korea)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid and Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT)
Status: COMPLETED
Conditions: Hereditary Hemorrhagic Telangiectasia
Interventions: DRUG: Tranexamic acid first, than placebo|DRUG: First placebo, than Tranexamic acid.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Affirmative Family and Individual Psychotherapy for Sexual and Gender Minority Adults and Their Nonaccepting Parents
Status: RECRUITING
Conditions: Mental Health Issue|Parent-Child Relations
Interventions: BEHAVIORAL: LGBTQ-affirmative CBT|BEHAVIORAL: ABFT-SGM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: US Guided Versus BlindI&D for Treatment of Soft Tissue Abscesses in the ED
Status: COMPLETED
Conditions: Abscess
Interventions: PROCEDURE: Ultrasound Guided Incision and Drainage|PROCEDURE: Blind Incision and Drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-Arm Study Evaluating Carboplatin/Gemcitabine in Combination With BSI-201 in Patients With Platinum-Resistant Recurrent Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: BSI-201
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose-Ranging, Multicenter Polysomnography Trial of PD 0200390 in Elderly Subjects With Primary Insomnia
Status: WITHDRAWN
Conditions: Insomnia
Interventions: DRUG: Placebo|DRUG: PD 0200390|DRUG: PD 0200390|DRUG: PD 0200390
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Saphenous Vein Graft Harvested From Upper Versus Lower Leg in Coronary Artery Bypass Grafting
Status: COMPLETED
Conditions: Triple Vessel Disease|Unstable Angina|Stable Angina|Myocardial Infarction
Interventions: PROCEDURE: Upper leg vein harvesting|PROCEDURE: Lower leg vein harvesting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Analgesic Efficacy of Fentanyl, Sufentanil and Butorphanol After Remifentanil Anesthesia
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Fentanyl citrate|DRUG: Sufentanil citrate|DRUG: Butorphanol tartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Endometrial Cancer.
Status: NOT_YET_RECRUITING
Conditions: Endometrial Cancer
Interventions: BIOLOGICAL: Lifileucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Interleukin-1 Beta on Low Testosterone Levels in Men With Obesity and Metabolic Syndrome
Status: COMPLETED
Conditions: Hypogonadism|Metabolic Syndrome X|Obesity
Interventions: DRUG: Anakinra|DRUG: Sodium Chloride 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Global Simplified Strategy on Thromboembolic Events in Emergency Department Patients With Suspected Pulmonary Embolism
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Embolism
Interventions: OTHER: MODS Modified simplified diagnostic strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Ambulation Training Utilizing an Exoskeleton Robot on Subjects With Spinal Cord Injury
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Ambulation training utilizing an exoskeleton robot
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessing Dietary Requirements in Relation to Resting Metabolic Rate in Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries|Dietary Habits
Interventions: DIAGNOSTIC_TEST: Resting Metabolic Rate|DIAGNOSTIC_TEST: Body Composition|BEHAVIORAL: Dietary Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Music Therapy Songwriting and Mental Health in Neonatel Intensive Care Unit (NICU) Parents
Status: NOT_YET_RECRUITING
Conditions: Mental Health Impairment
Interventions: OTHER: Music therapy songwriting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Combined Transcranial Magnetic Stimulation and Therapy for mTBI Related Headaches
Status: RECRUITING
Conditions: TBI (Traumatic Brain Injury)|Headache|Depression
Interventions: DEVICE: Active rTMS|BEHAVIORAL: Headache Management Therapy|DEVICE: Sham rTMS|BEHAVIORAL: Headache Education Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Treatment Effect of the Safety, Tolerability and Efficacy of AAT in Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes|Beta Cell Preservation
Interventions: DRUG: AAT( Alpha 1 Antitrypsin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Tong-Xie-Yao-Fang Granules for Diarrhea-predominant Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Diarrhea-predominant Irritable Bowel Syndrome
Interventions: DRUG: Tong-Xie-Yao-Fang|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 2D Perfusion DSA for the Quantification of Infrapopliteal Angioplasty
Status: COMPLETED
Conditions: Ischemia Limb
Interventions: DIAGNOSTIC_TEST: 2D perfusion digital subtraction angiography of the foot.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Lactobacillus Reuteri in Management of Helicobacter Pylori Infection in Dyspeptic Patients
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri|DIETARY_SUPPLEMENT: Placebo|DRUG: Omeprazole|DRUG: Amoxicillin|DRUG: Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficiency of the Web-Based Support Program Based on the Health Promotion Model in Pregnant Women With Preeclampsia
Status: UNKNOWN
Conditions: Healthy Lifestyle|Preeclampsia|Pregnancy; Renal Disease
Interventions: BEHAVIORAL: Web-based support program for pregnant women with preeclampsia based on the Health Promotion Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lum-Iva-biota: Exploring the Respiratory Mycobiota and Microbiota Profile in French CF Patients Taking Lumacaftor-Ivacaftor
Status: UNKNOWN
Conditions: Cystic Fibrosis
Interventions: BIOLOGICAL: the lung mycobiota and microbiota profile|BIOLOGICAL: the gut mycobiota and microbiota profile
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study on Traditional Chinese Medicine (TCM) Comprehensive Protocol of Prevention and Control in Diabetic Retinopathy
Status: COMPLETED
Conditions: Diabetic Retinopathy
Interventions: DRUG: Qi ming granula|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Astaxanthin, Exercise Inflammation, Skin Health
Status: COMPLETED
Conditions: Inflammatory Response|Metabolic Disturbance|Immune Suppression
Interventions: DIETARY_SUPPLEMENT: Astaxanthin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of a Moisturizing Cream and Baby Wash in the Management of Mild to Moderate Atopic Dermatitis in Infants, Toddlers and Children
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: OTHER: Wash IP|OTHER: Cream IP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label Pharmacokinetic Study of Iron Isomaltoside 1000 (Monofer®) Administered by 500 mg IV Bolus Injection or 1000 mg Intravenous to Patients With CKD
Status: COMPLETED
Conditions: Non-dialysis Dependent Chronic Kidney Disease
Interventions: DRUG: Iron isomaltoside 1000|DRUG: Iron isomaltoside 1000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures: A Multicenter Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Fracture of Tibia|Wound Heal|Infected Wound|Wound Complication|Wound Dehiscence
Interventions: DEVICE: Incisional Negative Pressure Wound Therapy (NPWT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Vildagliptin in Combination With Metformin in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Future of Spermatogenesis in Men With Sickle Cell Disease Medically Treated
Status: COMPLETED
Conditions: Drepanocytic Men Treated by Hydroxyurea for the First Time
Interventions: DRUG: Hydrea® (hydroxyurea )
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Warming Technique for Arterial Cannulation in Adult Patients
Status: COMPLETED
Conditions: Cardiac Disease Which Should be Treated by Surgery
Interventions: PROCEDURE: warming to increase local skin (puncture site) temperature
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Paradoxical Reactions in Non Immuno-compromized Patients With Extrapulmonary Tuberculosis
Status: COMPLETED
Conditions: Extrapulmonary Tuberculosis
Interventions: GENETIC: Genetic analysis|RADIATION: Body scan (CERVICO THORACO ABDOMINAL) + Cranian IRM|OTHER: Immunologic analysis|OTHER: QuantiferonTB Gold test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Melody® Transcatheter Pulmonary Valve Post-Approval Study
Status: COMPLETED
Conditions: Dysfunctional Right Ventricular Outflow Tract (RVOT) Conduit
Interventions: DEVICE: Melody® Transcatheter Pulmonary Valve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Synovial Fluid Molecular/Stem Cell Response to PRP in Knee Osteoarthritis: Clinical & Imaging Outcome Correlation
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: Platelet Rich Plasma|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Extension Study Investigating the Long-Term Safety of Degarelix Three-Month Depots in Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Degarelix|DRUG: Degarelix|DRUG: Degarelix
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The IAI-OCTA Study; a Study of OCT-Angiography Analysis Efficacy
Status: COMPLETED
Conditions: Wet Macular Degeneration
Interventions: DRUG: Aflibercept Ophthalmic|DEVICE: optovue angiovue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Acute Raspberry Intake on Metabolic Control and Cognitive Function
Status: COMPLETED
Conditions: Aging|Age-related Cognitive Decline|Obesity
Interventions: DIETARY_SUPPLEMENT: Active breakfast|DIETARY_SUPPLEMENT: Control breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Early Results of Slanted Recession of the Lateral Rectus Muscle for Intermittent Exotropia With Convergence Weakness
Status: COMPLETED
Conditions: Intermittent Exotropia
Interventions: PROCEDURE: Slanted recession of the lateral rectus muscle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ITT4 Intratesticular Hormonal Milieu in Man (ITT4)
Status: COMPLETED
Conditions: Healthy Males
Interventions: DRUG: Acyline|DRUG: Testosterone gel|DRUG: ketoconazole 400|DRUG: Ketoconazole 800|DRUG: Dutasteride|DRUG: Anastrozole|DRUG: Placebo ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact Evaluation of a Family-based Intervention With Burmese Migrant and Displaced Children and Families in Tak Province, Thailand
Status: COMPLETED
Conditions: Parenting Practices|Family Functioning|Child Psychosocial Well-being|Alcohol Use
Interventions: BEHAVIORAL: Family intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Role of the Endocannabinoid System in Sweet Taste Intensity and Liking
Status: COMPLETED
Conditions: Sensory Science
Interventions: DRUG: tetrahydrocannabinol|DRUG: cannabidiol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: 3D-MRE and 2D-MRE for Assessing Cirrhosis and Portal Hypertension
Status: RECRUITING
Conditions: Cirrhosis|Liver Portal Hypertension
Interventions: DEVICE: 3D-MRE|DEVICE: HVPG|DEVICE: 2D-MRE|DEVICE: HVPG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Occlusal Splints on Respiratory Variables in Obstructive Sleep Apnea (OSA) Patients
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Occlusal splints
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Near Infrared Spectroscopy (NIRS) as a Biomarker of Delirium in Hospitalized Older Adults Doing Physical Exercise
Status: UNKNOWN
Conditions: Delirium
Interventions: PROCEDURE: Multicomponent exercise training programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transversus Abdominis Plane Block With or Without Buprenorphine After Inguinal Hernia Surgery
Status: COMPLETED
Conditions: Inguinal Hernia|Pain, Postoperative
Interventions: DRUG: Ropivacaine 0.25%-NaCl 0.9% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Topical Antibiotics for Prevention of Intensive Care Unit (ICU) Central Line Infections
Status: WITHDRAWN
Conditions: Blood Stream Infections|Skin Diseases, Infectious
Interventions: DRUG: Polysporin Triple Therapy ointment|OTHER: Petroleum Jelly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sibling Oocyte Study of Medium for In Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) With no Human Serum Albumine
Status: WITHDRAWN
Conditions: In Vitro Fertilization|Infertility
Interventions: OTHER: Medium with no human serum albumine added|OTHER: Conventional medium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early CPAP And Large Volume Minimally Invasive Surfactant (ECALMIST) in Preterm Infants With RDS
Status: COMPLETED
Conditions: Respiratory Distress Syndrome
Interventions: DEVICE: ECALMIST|DEVICE: ECALMIST
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a MVM Dietary Supplement on Indices of Human Health
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: MVM/phytochemical supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Oral Semaglutide on Liver Fat and Body Composition in Liver Transplant Recipients With Diabetes Mellitus
Status: RECRUITING
Conditions: Liver Transplant; Complications|Diabete Mellitus
Interventions: DRUG: Semaglutide Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Adrenal Cortical Carcinoma|Alveolar Soft Part Sarcoma|Central Nervous System Neoplasm|Childhood Clear Cell Sarcoma of Soft Tissue|Clear Cell Sarcoma of Soft Tissue|Ewing Sarcoma|Hepatoblastoma|Hepatocellular Carcinoma|Osteosarcoma|Recurrent Adrenal Cortical Carcinoma|Recurrent Alveolar Soft Part Sarcoma|Recurrent Clear Cell Sarcoma of Soft Tissue|Recurrent Ewing Sarcoma|Recurrent Hepatoblastoma|Recurrent Hepatocellular Carcinoma|Recurrent Kidney Wilms Tumor|Recurrent Malignant Solid Neoplasm|Recurrent Osteosarcoma|Recurrent Primary Malignant Central Nervous System Neoplasm|Recurrent Renal Cell Carcinoma|Recurrent Rhabdomyosarcoma|Recurrent Soft Tissue Sarcoma|Recurrent Thyroid Gland Medullary Carcinoma|Refractory Adrenal Cortical Carcinoma|Refractory Alveolar Soft Part Sarcoma|Refractory Clear Cell Sarcoma of Soft Tissue|Refractory Ewing Sarcoma|Refractory Hepatoblastoma|Refractory Hepatocellular Carcinoma|Refractory Malignant Solid Neoplasm|Refractory Osteosarcoma|Refractory Primary Central Nervous System Neoplasm|Refractory Primary Malignant Central Nervous System Neoplasm|Refractory Renal Cell Carcinoma|Refractory Rhabdomyosarcoma|Refractory Soft Tissue Sarcoma|Refractory Thyroid Gland Medullary Carcinoma|Refractory Wilms Tumor|Renal Cell Carcinoma|Rhabdomyosarcoma|Soft Tissue Sarcoma|Solid Neoplasm|Thyroid Gland Medullary Carcinoma|Wilms Tumor
Interventions: DRUG: Cabozantinib|DRUG: Cabozantinib S-malate|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robot-assisted Urological Surgeries Using the MicroHand S Robot
Status: RECRUITING
Conditions: Bladder Cancer|Prostate Cancer|Renal Cancer
Interventions: DEVICE: robot-assisted surgery|DEVICE: robot-assisted surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study of Venetoclax in Combination With Obinutuzumab in Participants With Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Lymphocytic Leukemia, Chronic
Interventions: DRUG: Obinutuzumab|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Cystic Fibrosis (CF) Patients With Pseudomonas Aeruginosa (PA)
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: AZLI 75 mg two times a day (BID)/ three times a day (TID)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of MP-424, Peginterferon Alfa-2b and Ribavirin in Relapser Genotype 2 Hepatitis C Infected Patients
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: MP-424 (generic name:Telaprevir)|DRUG: Ribavirin|DRUG: Peginterferon alfa-2b
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetics Study of Tissue Collected From Patients With Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Leukemia
Interventions: GENETIC: microarray analysis|GENETIC: molecular genetic technique|GENETIC: mutation analysis|GENETIC: polymerase chain reaction|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: diagnostic laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Switching From Insulin Glargine to Insulin Degludec in Subjects With Type 2 Diabetes Mellitus (BEGIN™)
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec|DRUG: insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Smoking Environments on Craving and Smoking (CameraCue2.0)
Status: COMPLETED
Conditions: Cigarette Smoking
Interventions: DRUG: Nicotine Patch|DRUG: Varenicline|DRUG: Placebo Nicotine Patch|DRUG: Placebo Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Miglustat in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: miglustat|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of XL184 (Cabozantinib) in Combination With Temozolomide and Radiation Therapy in the Initial Treatment of Adults With Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma|Giant Cell Glioblastoma|Gliosarcoma
Interventions: DRUG: XL184|DRUG: temozolomide|DRUG: temozolomide|RADIATION: Radiation Therapy|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LUNGevity: Lung Cancer Stigma Community Based Participatory Research
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer
Interventions: BEHAVIORAL: Ultra-brief mindfulness intervention video|BEHAVIORAL: Forgiveness video|BEHAVIORAL: ACT values video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Orange Consumption on Carbohydrate and Lipid Metabolism in Subjects With MAFLD (Metabolic Associated Fatty Liver Disease)
Status: RECRUITING
Conditions: Metabolic Disease|Fatty Liver, Nonalcoholic
Interventions: DIETARY_SUPPLEMENT: Dietary supplementation with fresh oranges|DIETARY_SUPPLEMENT: Balanced Diet without oranges
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Jaktinib Hydrochloride Cream For Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Jaktinib Hydrochloride Cream|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Dry Needling of Active Trigger Points in Neck Muscles in Patients With Chronic Cervical Pain
Status: NOT_YET_RECRUITING
Conditions: Cervical Pain
Interventions: OTHER: Dry Needling|OTHER: Stretch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PI-88 in Treating Patients With an Advanced Malignancy (Cancer) or Stage IV Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: PI-88
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diaphragmatic Rapid Shallow Breathing Index for Predicting Weaning Outcome From Mechanical Ventilation
Status: COMPLETED
Conditions: Weaning Failure
Interventions: OTHER: Diaphragm ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Comparison of Respiratory Tolerance to I.V. Versus Sublingual Sedation During Bronchoscopy. (TORSIV)
Status: TERMINATED
Conditions: Sedation During Bronchoscopy
Interventions: DRUG: I.V Sedation|DRUG: sublingual sedation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Affixing Polypropylene Mesh Using Barbed Suture (Quill™ Srs) During Laparoscopic Sacrocolpopexy Randomized Controlled Trial (Quill Lsc)
Status: COMPLETED
Conditions: Prolapse
Interventions: PROCEDURE: Quill suture vs. Interrupted suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lacosamide Versus Topiramate in Migraine
Status: RECRUITING
Conditions: Migraine Disorders
Interventions: DRUG: Lacosamide 50 MG|DRUG: Topiramate 50Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carboplatin and Paclitaxel in Patients With Metastatic, Castrate-Resistant Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omarigliptin (MK-3102) Clinical Trial - Add-on to Oral Antihyperglycemic Agent Study in Japanese Participants With Type 2 Diabetes Mellitus (MK-3102-015)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Omarigliptin|DRUG: Matching placebo to omarigliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SCID Bu/Flu/ATG Study With T Cell Depletion
Status: TERMINATED
Conditions: Severe Combined Immunodeficiency
Interventions: BIOLOGICAL: unrelated BM with T cell depletion|BIOLOGICAL: unrelated cord blood|BIOLOGICAL: haplo BM with T cell depletion|DEVICE: unrelated PBSC with T cell depletion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Normobaric Oxygen on Chronic Cerebral Ischemia
Status: COMPLETED
Conditions: Normobaric Oxygen|Cerebral Ischemia
Interventions: DEVICE: normobaric oxygen|DEVICE: room air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Itraconazole in Preventing the Return of Histoplasmosis, a Fungal Infection, in Patients With AIDS
Status: COMPLETED
Conditions: HIV Infections|Histoplasmosis
Interventions: DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Evaluation of RPH-104 Administered at Different Doses to Patients With Acute Gout Attack
Status: TERMINATED
Conditions: Gout Attack
Interventions: DRUG: RPH - 104|DRUG: Voltaren®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study To Estimate The Relative Bioavailability And Food Effect Of PF-04620110 In Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: PF-04620110
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liquid Biopsy: Intercepting Mutational Trajectories of HER2 (Human Epidermal Growth Factor Receptor 2) Breast Cancer (GIM21 Trial)
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: OTHER: Both blood and tissues collection for patients with metastatic breast cancer HER2+ pretreated with no more than one line of anti-HER2 therapy for advanced breast cancer.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: MsFLASH-02: Interventions for Relief of Menopausal Symptoms: A 3-by-2 Factorial Design Examining Yoga, Exercise, and Omega-3 Supplementation
Status: COMPLETED
Conditions: Hot Flashes|Menopause|Vasomotor Symptoms
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Omega-3|BEHAVIORAL: Yoga|BEHAVIORAL: Exercise|BEHAVIORAL: Usual Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Disitamab Vedotin Alone or With Other Anticancer Drugs in Solid Tumors
Status: RECRUITING
Conditions: Breast Neoplasms|Gastroesophageal Junction Adenocarcinoma|HER2 Low Breast Neoplasms|HER2 Positive Breast Neoplasms|Stomach Neoplasms|Triple Negative Breast Neoplasms|Metastatic Breast Cancer|Metastatic Gastric Cancer|Advanced Breast Cancer|Advanced Gastric Cancer
Interventions: DRUG: disitamab vedotin|DRUG: tucatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methylprednisolone for Patients With COVID-19 Severe Acute Respiratory Syndrome
Status: COMPLETED
Conditions: Severe Acute Respiratory Syndrome (SARS) Pneumonia|Coronavirus Infections|ARDS, Human
Interventions: DRUG: Methylprednisolone|OTHER: standard care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preventing Learning Problems in Young Children: A Public Health and Physician-Based Outreach
Status: UNKNOWN
Conditions: Developmental Disabilities|Language Development Disorders
Interventions: BEHAVIORAL: Age-specific parenting newsletters and developmental toys|BEHAVIORAL: Parent-completed Ages & Stages Questionnaires|BEHAVIORAL: Clinic-based distribution of children's books
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: Phase 1 Study of 68Ga-R8760
Status: ACTIVE_NOT_RECRUITING
Conditions: Adrenocortical Carcinoma
Interventions: DRUG: 68Ga-R8760 injection at pre-defined dose levels|DRUG: 68Ga-R8760 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bone Marrow Sparing Image-Guided Radiation Therapy (RT) Incorporating Novel Use of GCSF and FDG-PET Imaging
Status: RECRUITING
Conditions: Cervix Cancer|Endometrial Cancer
Interventions: DIAGNOSTIC_TEST: FDG PET/CT|DRUG: GCSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibuprofen Versus Placebo For Muscle Soreness
Status: COMPLETED
Conditions: Muscle Soreness
Interventions: DRUG: Ibuprofen 400 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Safety of Different Doses of Olaparib Given Radium-223 for Men With Advanced Prostate Cancer With Bone Metastasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Castration-Resistant Prostate Carcinoma|Metastatic Prostate Adenocarcinoma|Stage IVB Prostate Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Magnetic Resonance Imaging|DRUG: Olaparib|OTHER: Quality-of-Life Assessment|RADIATION: Radium Ra 223 Dichloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Interpersonal Relationships and Social Rhythm Therapy Individuals With Bipolar Disorder
Status: UNKNOWN
Conditions: Bipolar Disorder|Bipolar I Disorder|Bipolar II Disorder
Interventions: BEHAVIORAL: Peplau Interpersonal Relations based IPSRT will be applied to the intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Differences and Wearing Safety and Comfort of New Defocus Incorporated Multiple Segments Spectacle Lenses
Status: NOT_YET_RECRUITING
Conditions: Myopia, Progressive
Interventions: DEVICE: defocus spectacle lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Trial Comparing S1 Generic With Capecitabine in Metastatic Breast Cancer (MBC)
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: capecitabine|DRUG: S1 generic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of VY-AADC01 for Advanced Parkinson's Disease
Status: COMPLETED
Conditions: Idiopathic Parkinson's Disease|Parkinson's Disease|Basal Ganglia Disease|Brain Diseases|Central Nervous System Diseases|Movement Disorders|Nervous System Diseases|Neurodegenerative Diseases|Parkinsonian Disorders
Interventions: DRUG: VY-AADC01
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Setmelanotide for the Treatment of Early-Onset Pro-Opiomelanocortin (POMC) Deficiency Obesity
Status: COMPLETED
Conditions: Pro-opiomelanocortin (POMC) Deficiency Obesity
Interventions: DRUG: Setmelanotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of DS-8201a in Metastatic Breast Cancer Previously Treated With Trastuzumab Emtansine (T-DM1)
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: DS-8201a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Optical Genome Mapping in Phi Negative Myeloproliferative Neoplasia in the Detection of Acquired Cytogenetic Abnormalities
Status: RECRUITING
Conditions: Myeloproliferative Neoplasm|Optical Genome Mapping|Cytogenetics|Clonality|Prognostic Stratification
Interventions: OTHER: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Varenicline for Nicotine Vaping Cessation in Adolescents
Status: COMPLETED
Conditions: Vaping|Nicotine Dependence
Interventions: DRUG: Double Blind Varenicline|DRUG: Double Blind Placebo|BEHAVIORAL: QuitVaping|BEHAVIORAL: This Is Quitting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cetuximab and Carboplatin in Treating Patients With Recurrent Ovarian Epithelial Cancer or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Agreement Between a Consultation With a Nurse Acquiring Three-dimensional Intraoral Images Made With a 3D Intraoral Camera and the Standard Consultation With a Dental Surgeon, in Institutionalized Elderly Subjects
Status: NOT_YET_RECRUITING
Conditions: Dental Care for Institutionalized Elderly Persons
Interventions: OTHER: Three-dimensional dental acquisition
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pre-Operative, Single-Dose Ipilimumab and/or Cryoablation in Early Stage/Resectable Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Invasive Adenocarcinoma of the Breast
Interventions: PROCEDURE: Cryoablation|BIOLOGICAL: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy and Safety of Bronpass Tab. in Patients With Chronic Obstructive Pulmonary Disease
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Bronpass Tab.|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT