pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Cooperation for Improved Pharmacotherapy in Home-dwelling Elderly People Receiving Polypharmacy - The COOP Study
Status: COMPLETED
Conditions: Drug Usage
Interventions: OTHER: Comprehensive drug review
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Scopolamine Challenge Study
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Placebo|DRUG: Scopolamine|DRUG: PF-05212377|DRUG: Scopolamine|DRUG: PF-05212377|DRUG: scopolamine|DRUG: PF-05212377|DRUG: scopolamine|DRUG: Donepezil|DRUG: Scopolamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effects of Blueberry on Gut Microbiota and Metabolic Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Gut Microbiota|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: 50 g of blueberry powder, taken daily for 8 weeks|DIETARY_SUPPLEMENT: 50g of placebo blueberry powder, taken daily for 8 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Anti-Androgens and Cabazitaxel in Defining Complete Response in Prostatectomy (ACDC Trial)
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Abiraterone acetate with prednisone|DRUG: Leuprolide|DRUG: Cabazitaxel with peg-filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Global Postural Re-education Versus Laser-guided Exercise in Non-specific Chronic Low Back Pain
Status: NOT_YET_RECRUITING
Conditions: Pain, Back
Interventions: OTHER: Global Postural Re-education|OTHER: Laser-guided Supervised Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neuraxial Ultrasound for Thoracic Epidural Placement
Status: COMPLETED
Conditions: Analgesia, Epidural
Interventions: PROCEDURE: Thoracic Epidural Placement|DRUG: Bupivacaine 0.05%|DRUG: Hydromorphone 0.01mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efaproxiral Plus Carmustine in Treating Patients With Progressive or Recurrent Malignant Glioma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: carmustine|DRUG: efaproxiral
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Medically-tailored Meal Delivery Service on Changes in Hemoglobin A1c (HbA1c) in Patients With Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Medically tailored meals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Screening of Septo-optic Dysplasia During a Fetal Examination at 16-20 Weeks of Gestation
Status: COMPLETED
Conditions: 2D Ultrasound|Cavum Septum Pellucidum|Septooptic Dysplasia|Optic Chiasma|Willis Polygon
Interventions: DIAGNOSTIC_TEST: Displaying optic chiasm for screening septooptic dysplasia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hypofractionated Accelerated Pelvic Nodal Radiotherapy (GCC 2048)
Status: RECRUITING
Conditions: Prostate Cancer|Prostate Adenocarcinoma
Interventions: RADIATION: Hypofractionated Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Concurrent Versus Sequential Tamoxifen With Radiotherapy in Breast Cancer Patients
Status: UNKNOWN
Conditions: Pulmonary Fibrosis|Breast Cancer
Interventions: DRUG: Tamoxifen|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single and Multiple Ascending Dose Study of CK-3773274 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Symptomatic Obstructive Hypertrophic Cardiomyopathy|Healthy Subjects
Interventions: DRUG: CK-3773274 - Granules in Capsule|DRUG: Placebo - Granules in Capsule|DRUG: CK-3773274 - Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Anemia in Subjects With Non-Myeloid Malignancy Receiving Multicycle Chemotherapy
Status: COMPLETED
Conditions: Anemia|Non-Myeloid Malignancies
Interventions: DRUG: Darbepoetin alfa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Discovering Adolescents' Talents and Life Projects as a Key Factor in Their Life Satisfaction
Status: NOT_YET_RECRUITING
Conditions: Healthy|Adolescent Development
Interventions: BEHAVIORAL: Experimental: Humanistic Integrative Psychotherapy and Identity Exploration (HIP+EYME)|BEHAVIORAL: Experimental: Humanistic Integrative Psychotherapy, Identity, and Geniotype Exploration (HIP+EYME+GENIOTYPE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings
Status: COMPLETED
Conditions: Childhood Malignant Ovarian Germ Cell Tumor|Childhood Malignant Testicular Germ Cell Tumor|Ovarian Choriocarcinoma|Ovarian Embryonal Carcinoma|Ovarian Mixed Germ Cell Tumor|Ovarian Teratoma|Ovarian Yolk Sac Tumor|Testicular Choriocarcinoma|Testicular Embryonal Carcinoma|Testicular Seminoma|Testicular Teratoma|Testicular Yolk Sac Tumor
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Long-term Safety and Tolerability of BMS-820836 in the Treatment of Patients With Treatment Resistant Major Depression
Status: TERMINATED
Conditions: Depression
Interventions: DRUG: Placebo matching with BMS-820836|DRUG: BMS-820836|DRUG: BMS-820836|DRUG: BMS-820836
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Internet-delivered Behaviour Therapy for Children and Adolescents With Tourette's Disorder
Status: COMPLETED
Conditions: Tourette's Disorder|Persistent (Chronic) Motor or Vocal Tic Disorder
Interventions: BEHAVIORAL: Exposure and response prevention (ERP)|BEHAVIORAL: Education on tics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Pola-ZR2 Versus ZR2 in the Treatment of Old Patients With de Novo Diffuse Large B-cell Lymphoma
Status: RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: polatuzumab vedotin, zanubrutinib, rituximab and lenalidomide|DRUG: zanubrutinib, rituximab and lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Treatment Preference During Cheek Contouring Comparing Restylane® SubQ With and Without the Addition of Lidocaine Hydrochloride
Status: COMPLETED
Conditions: Facial Tissue Augmentation
Interventions: DEVICE: Restylane SubQ|DEVICE: Restylane SubQ Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effect and Safety of Envafolimab Combined With Endostar/S-1 in Second-line of Advanced Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Envafolimab plus Endostar and S-1|DRUG: Envafolimab plus Endostar|DRUG: Envafolimab plus S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of L-Ornithine L-Aspartate in Acute Hepatic Encephalopathy.
Status: COMPLETED
Conditions: Hepatic Encephalopathy
Interventions: DRUG: L-ornithine-L-aspartate|DRUG: Lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics and Pharmacodynamics of Two IDegAsp (One Explorative) Preparations and Two Insulin Degludec (One Explorative) Preparations in Japanese Subjects
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: insulin degludec|DRUG: insulin degludec/insulin aspart 30|DRUG: insulin degludec/insulin aspart 45|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: VX15/2503 With or Without Ipilimumab and/or Nivolumab in Patients With Resectable Stage IIIB-D Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Pathologic Stage IIIB Cutaneous Melanoma AJCC v8|Pathologic Stage IIIC Cutaneous Melanoma AJCC v8|Pathologic Stage IIID Cutaneous Melanoma AJCC v8
Interventions: BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab|BIOLOGICAL: VX15/2503|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Toripalimab Combined With Axitinib as Neoadjuvant Therapy in Patients With Non-metastatic Locally Advanced Nonmetastatic Clear Cell Renal Cell Carcinoma
Status: COMPLETED
Conditions: Neoadjuvant Therapy of Non-metastatic Locally Advanced Renal Cell Carcinoma
Interventions: DRUG: Toripalimab|DRUG: Axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Striae Distensae With Fractional Radiofrequency and Topical Tretinoin
Status: COMPLETED
Conditions: Striae Distensae
Interventions: COMBINATION_PRODUCT: Fractional radiofrequency and topical Tretinoin|DRUG: Topical Tretinoin|DEVICE: Fractional radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Growth Hormone Pre-treatment for 6 Weeks Prior to Ovulation Induction for IVF
Status: UNKNOWN
Conditions: Female Infertility Due to Diminished Ovarian Reserve
Interventions: DRUG: Human Growth Hormone|DRUG: Follicle Stimulating Hormone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PO Pain Management With Extended-release Dinalbuphine Sebacate in Patients Undergoing Arthroscopic Shoulder Surgery
Status: RECRUITING
Conditions: Anesthesiology|Orthopedic
Interventions: DRUG: DS group|DRUG: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Platelet Count and Function After Usage of Two Different Cell Saver Devices During Liver Transplant Surgery
Status: NOT_YET_RECRUITING
Conditions: Liver Transplant|Hemorrhage, Surgical
Interventions: DEVICE: Cell Salvage Autotransfusion: SAME™ device|DEVICE: Cell Salvage Autotransfusion: Autolog™ device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Left Atrial Mechanical Function Improvement After Atrial Fibrillation Catheter Ablation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Telmisartan 80 mg and amlodipine 5 mg|DRUG: Placebo (for telmisartan and amlodipine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Antireflux Ablation of the Cardia Mucosa vs Placebo for the Treatment of Gastroesophageal Reflux Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastroesophageal Reflux Disease
Interventions: PROCEDURE: ARMA (antireflux ablation of the cardiac mucosa)|PROCEDURE: upper digestive endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Kabat Rehabilitation Versus Mime Therapy on Facial Disability and Synkinesis in Patients of Bell's Palsy
Status: RECRUITING
Conditions: Bell Palsy
Interventions: OTHER: Kabat Therapy|OTHER: Mime Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Radiation Therapy and Ipilimumab in Treating Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Liver Metastases|Lung Metastases|Recurrent Melanoma|Stage IV Melanoma|Tumors Metastatic to Brain
Interventions: BIOLOGICAL: ipilimumab|RADIATION: stereotactic radiosurgery|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjunct Methadone to Decrease the Duration of Mechanical Ventilation in the Medical Intensive Care Unit
Status: UNKNOWN
Conditions: Opioid Use, Unspecified With Withdrawal|Opioid-Induced Disorders|Delirium
Interventions: DRUG: Methadone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ceftolozane/Tazobactam Continuous Infusion for Infective Exacerbations of Cystic Fibrosis and Bronchiectasis
Status: NOT_YET_RECRUITING
Conditions: Bronchiectasis|Cystic Fibrosis|Pseudomonas Aeruginosa|Burkholderia Cepacia Infection
Interventions: DRUG: Ceftolozane/tazobactam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Added Varnum Mouthpiece on Pharyngeal Collapsibility and Sleep Apnea Severity in Mouth Breathers.
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Varnum mouthpiece
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate ENERGI-F703 GEL in Venous Leg Ulcer
Status: RECRUITING
Conditions: Venous Leg Ulcer
Interventions: DRUG: ENERGI-F703 GEL|DRUG: ENERGI-F703 GEL matched vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects
Status: COMPLETED
Conditions: Obesity|Overweight
Interventions: DRUG: Naltrexone SR 32 mg/bupropion SR 360 mg/day|DRUG: Placebo|BEHAVIORAL: Ancillary therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Trial of DAR-901
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: DAR-901|BIOLOGICAL: BCG|BIOLOGICAL: Sterile saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study)
Status: COMPLETED
Conditions: Graves' Ophthalmopathy
Interventions: DRUG: Bimatoprost|DRUG: Eye drop solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Thrust Joint Manipulation on the Resting and Contracting Thickness of Transversus Abdominis in Subjects With Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Thrust Joint Manipulation of the Lumbar Spine|OTHER: Non-thrust Joint Manipulation of the Lumbar Spine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glucosamine Sulphate, Ginger, Ginger-Avocado-Soya and Ginger-Ibuprofen for Chronic Back Pain
Status: COMPLETED
Conditions: Back Pain
Interventions: DRUG: Glucosamine sulphate|DRUG: Ginger|DRUG: Ginger-Avocado-Soya|DRUG: Ginger-ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Cannabis Use, Cognition, and the Endocannabinoid System in HIV
Status: RECRUITING
Conditions: HIV-1-infection
Interventions: DRUG: 10 mg Δ9-tetrahydrocannabinol (THC)|DRUG: 600 mg cannabidiol (CBD)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Efficacy of Using a Smartphone App to Support Shared Decision Making in People With a Diagnosis of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia, Schizotypal and Delusional Disorders
Interventions: DEVICE: Momentum app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Differential Acute Tolerance Development to Effects of Nitrous Oxide - 7
Status: COMPLETED
Conditions: Opioid-Related Disorders|Substance-Related Disorders
Interventions: DRUG: Nitrous oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Second-line Therapy Antiretroviral in Patients Who Failed Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI) - Based Regimens
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: LPV/r|DRUG: LPV/r + TDF/FTC or TDF/3TC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dexmedetomidine on Decreasing Emergence Agitation and Delirium in Pediatric Patients Undergoing Strabismus Surgery
Status: COMPLETED
Conditions: Strabismus
Interventions: DRUG: Dexmedetomidine|DRUG: placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Function After Minimally Invasive Aortic Valve Implantation
Status: COMPLETED
Conditions: Aortic Valve Stenosis|Heart Valve Diseases
Interventions: PROCEDURE: Minimally invasive aortic valve replacement|PROCEDURE: Conventional aortic valve replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Plug-based Femoral Arteriotomy Closure Device Use in Surgery for Acute Type A Aortic Disection
Status: COMPLETED
Conditions: Aortic Dissection
Interventions: PROCEDURE: Percutaneous arteriotomy closed using a plug-based arteriotomy closure device|PROCEDURE: Surgical cut-down and arterial puncture under direct vision
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Strategies to Improve Islet Survival
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: PROCEDURE: Islet transplant|DRUG: Antithymocyte globulin|DRUG: Basiliximab|DRUG: Lisofylline|DRUG: Sirolimus|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Relapse Rate Reduced by Home Monitoring of IBD Patients Tightly or on Demand by FC and Disease Activity?
Status: UNKNOWN
Conditions: Inflammatory Bowel Disease
Interventions: OTHER: SI|OTHER: OD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: ACTIV-6: COVID-19 Study of Repurposed Medications - Arm G (Metformin)
Status: ACTIVE_NOT_RECRUITING
Conditions: Covid19
Interventions: OTHER: Placebo|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Physiotherapy in Hypoxic AECOPD Patients
Status: UNKNOWN
Conditions: COPD Exacerbation
Interventions: OTHER: Global Exercise intervention|OTHER: Functional Electrostimulation Group|OTHER: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Detect Changes in Urinary and Gut Microbiome During Androgen Deprivation Therapy and Radiation Therapy in Patients With Prostate Cancer
Status: RECRUITING
Conditions: Stage I Prostate Cancer AJCC v7|Stage II Prostate Cancer AJCC v7|Stage IIA Prostate Cancer AJCC v7|Stage IIB Prostate Cancer AJCC v7|Stage III Prostate Cancer AJCC v7|Stage IV Prostate Cancer AJCC v7
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Electronic Health Record Review|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sodium Chloride vs. Glucose Solute as a Volume Replacement Therapy During Decongestion in Acute Heart Failure
Status: COMPLETED
Conditions: Acute Heart Failure|Congestion|Heart Failure
Interventions: DRUG: Furosemide intravenous infusion|DRUG: Continous intravenous infusion of 0.9% Sodium Chloride solution|DRUG: Continous intravenous infusion of 5% Glucose solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Creatine Augmentation Treatment in Major Depressive Disorder Subjects
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DIETARY_SUPPLEMENT: Creatine monohydrate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determination of the Predictors of Nocturnal Desaturation in Postpartum Women
Status: COMPLETED
Conditions: Sleep Disordered Breathing|Nocturnal Oxygen Desaturation|Upper Airway Edema
Interventions: PROCEDURE: Forty-five degrees elevated upper body position|PROCEDURE: non-elevated upper body position|DEVICE: Noninvasive wrist pulse oximeter (WristOx Model 3150)|OTHER: Stop-Bang questionnaire|OTHER: Epworth Sleepiness Scale|OTHER: P-SAP Score|OTHER: self-reported pain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stability of Maxillary Anterior Teeth After Two Years of Retention in Adolescents Comparing Two Bonded and a Vacuum-formed Retainer
Status: COMPLETED
Conditions: Orthodontic Appliance Complication
Interventions: OTHER: Measuring changes of Little´s irregularity index ( sum of 5 contact point discrepancies together) measured in mm 2 years after retention have been I place.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: THUNDER: Acute Ischemic Stroke Study With the Penumbra System® Including Thunderbolt™ Aspiration Tubing
Status: RECRUITING
Conditions: Acute Ischemic Stroke|Large Vessel Occlusion
Interventions: DEVICE: Mechanical Thrombectomy (Penumbra System with Thunderbolt)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Acne Scarring With a Novel Procedure Combination
Status: COMPLETED
Conditions: Acne Scarring
Interventions: PROCEDURE: subdermal manipulation ONLY|PROCEDURE: subdermal manipulation AND injection of a filler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Nasal Carbon Dioxide (CO2) on Nasal Congestion in Subjects With Perennial Allergic Rhinitis
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis
Interventions: DRUG: Nasal Carbon Dioxide|DRUG: Nasal Carbon Dioxide|DRUG: Nasal Carbon Dioxide|DRUG: Nasal Carbon Dioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of the Safety, Reactogenicity, and Immunogenicity of Sm-TSP-2/Alhydrogel® With or Without GLA-AF for Intestinal Schistosomiasis in Healthy Adults
Status: COMPLETED
Conditions: Schistosomiasis
Interventions: OTHER: Placebo|BIOLOGICAL: Sm-TSP-2/Alhydrogel|BIOLOGICAL: Sm-TSP-2/Alhydrogel/GLA-AF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Automated Robotic Maneuvering System (RMS) vs Manual Reposition Maneuver in Treatment of Benign Paroxysmal Positional Vertigo (BPPV)
Status: COMPLETED
Conditions: Benign Paroxysmal Positional Vertigo
Interventions: DEVICE: Automated vertigo repositioning chair|OTHER: Canalith Reposition Maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Double-blind Placebo Surgery Trial for Treatment of Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Surgery
Interventions: PROCEDURE: Neural implantation group|PROCEDURE: Sham surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided - Incisionless Threaded Carpal Tunnel Release
Status: SUSPENDED
Conditions: Carpal Tunnel Syndrome
Interventions: PROCEDURE: Incisionless Threaded Carpal Tunnel|PROCEDURE: Standard Mini-Open Carpal Tunnel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caring for the Radial Artery Post-angiogram
Status: COMPLETED
Conditions: Transradial Angiogram
Interventions: DEVICE: Terumo TR wristband|DEVICE: Terumo TR wristband|DEVICE: Clo-Sur-P.A.D.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Children- Sit Less, Move More (C-SLAMM): Increasing Physical Activity and Decreasing Sedentary Behaviour in Children
Status: COMPLETED
Conditions: Physical Inactivity|Sedentary Behavior|Health Behavior|Child Behavior|Physical Activity
Interventions: OTHER: C-SLAMM Study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Immediate vs. Conditional Use of Antibiotics in Uncomplicated Urinary Tract Infection (UTI) - ICUTI
Status: COMPLETED
Conditions: Urinary Tract Infection
Interventions: DRUG: Ibuprofen|DRUG: Fosfomycin-Trometamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating 13-valent Pneumococcal Conjugate Vaccine in Healthy Children
Status: COMPLETED
Conditions: Pneumococcal Vaccines
Interventions: BIOLOGICAL: 13vPnC|BIOLOGICAL: 13vPnC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Micafungin for Injection in Prevention and Treatment of Fungal Infection in Hematological Tumors
Status: UNKNOWN
Conditions: Hematological Tumors Patients With High Risk Factors of Invasive Fungal Disease
Interventions: DRUG: Micafungin Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Replacing Protein Via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients
Status: COMPLETED
Conditions: Critical Illness|ARDS|Septic Shock|Multiple Trauma|Seizure Disorder|Hemorrhagic Shock
Interventions: DIETARY_SUPPLEMENT: Replenish Protein|DIETARY_SUPPLEMENT: Standard protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Urinary Tract Infections Rates Using 50% Dextrose Plus Washout Versus Normal Saline as Cystoscopy Fluid
Status: ACTIVE_NOT_RECRUITING
Conditions: Hysterectomy
Interventions: PROCEDURE: 50% dextrose|PROCEDURE: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of ACT-541468 in Healthy Young Adults and Elderly Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: ACT-541468 (hydrochloride salt)|DRUG: ACT-541468 (free base)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Lowering the Risk of Operative Complications Using Atorvastatin Loading Dose
Status: COMPLETED
Conditions: Myocardial Infarction|Peripheral Vascular Disease|Aortic Aneurism
Interventions: DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of SRK-T With Kane Formula for Prediction of Refractive Outcome After Phacoemulsification
Status: COMPLETED
Conditions: Cataract; Surgery; Phacoemulsification; Biometry; Intraocular Lens Power
Interventions: OTHER: Biometry with Kane formula|OTHER: Biometry with SRK-T formula
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastric Preparation of Magnetic-controlled Capsule Endoscopy
Status: UNKNOWN
Conditions: Stomach Diseases
Interventions: OTHER: clear water|DRUG: simethicone|DRUG: simethicone combined with pronase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Adolescent Trauma Recovery and Stress Disorders Collaborative Care (ATRSCC) Model Program Trial
Status: COMPLETED
Conditions: Post-traumatic Stress Disorder|Alcohol Abuse|Alcohol Dependence
Interventions: BEHAVIORAL: Adolescent Trauma Support Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Internet-delivered Cognitive-Behavioral Intervention for Insomniac Cancer Survivors
Status: RECRUITING
Conditions: Insomnia|Survivorship|Cancer
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Mirvetuximab Soravtansine vs. Investigator's Choice (IC) of Chemotherapy in Platinum-Resistant, Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha (FRα) Expression
Status: ACTIVE_NOT_RECRUITING
Conditions: Epithelial Ovarian Cancer|Peritoneal Cancer|Fallopian Tube Cancer
Interventions: DRUG: Mirvetuximab Soravtansine|DRUG: Paclitaxel|DRUG: Topotecan|DRUG: Pegylated liposomal doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of Two Azithromycin Tablet Formulations in Indonesian Healthy Subjects
Status: COMPLETED
Conditions: Fasting
Interventions: DRUG: Azithromycin|DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Investigating the Effect of Dronabinol on Post-surgical Pain
Status: WITHDRAWN
Conditions: Knee Replacement|Arthropathy of Knee
Interventions: DRUG: Dronabinol 5mg Cap|DRUG: Non-active comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Wide Pulse Pressure on the Predictability of Stroke Volume Variation for Fluid Responsiveness in Patients Undergoing Off-pump Coronary Artery Bypass Graft
Status: COMPLETED
Conditions: Stroke Volume Variation
Interventions: OTHER: HES 130/0.4 (VoluvenⓇ, Fresenius Kabi, Graz, Austria) 500mL loading
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Study of Acamprosate in Fragile x Syndrome
Status: COMPLETED
Conditions: Fragile X Syndrome
Interventions: DRUG: acamprosate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Demonstrate the Clinical Efficacy of Levofloxacin in the Treatment of Pneumonia
Status: COMPLETED
Conditions: Pneumonia
Interventions: DRUG: Levofloxacin|DRUG: Piperacillin/Tazobactam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Effect of Optical Defocus and Low Dose Atropine in Myopia Control
Status: NOT_YET_RECRUITING
Conditions: Myopia
Interventions: DEVICE: Defocus Incorporated Multiple Segments lenses|DEVICE: single vision spectacle lenses|DRUG: Low dose atropine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Cloud DX Platform as a Tool for Self-management and Asynchronous Remote-monitoring of COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Cloud Dx Kit with self-monitoring|DEVICE: Cloud Dx Kit with remote-monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Influence of the Design of the Transmucosal Abutment on the Periimplant Bone Level
Status: RECRUITING
Conditions: Peri-implant Marginal Bone Loss|Peri-implant Bone Level|Transmucosal Abutment Design|Peri-implant Bone Loss
Interventions: DEVICE: Conventional transmucosal abutment design|DEVICE: Narrow transmucosal abutment design
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carfilzomib + Lenalidomide and Dexamethasone for BTK Inhibitors Relapsed-refractory or Intolerant MCL
Status: UNKNOWN
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Carfilzomib|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC
Status: RECRUITING
Conditions: Primary Immunodeficiency (PID)|Congenital Bone Marrow Failure Syndromes|Inherited Metabolic Disorders (IMD)|Hereditary Anemias|Inflammatory Conditions
Interventions: DRUG: data collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TRIMBOW® and RELVAR® on Lung Stiffness Reduction Assessed Through Forced Oscillation Technique in Patients With COPD
Status: WITHDRAWN
Conditions: COPD
Interventions: DRUG: Beclometasone Dipropionate / Formoterol Fumarate / Glycopyrronium 100/6/10 mcg|DRUG: Fluticasone Furoate / Vilanterol Trifenatate 100/25 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT Investigating Pre-cesarean Vaginal Wash of Chlorhexidine vs Povidone-iodine for Patient With Ruptured Amniotic Membrane.
Status: WITHDRAWN
Conditions: Cesarean Section Complications
Interventions: DRUG: EZ scrub vaginal chlorhexidine 4% solution|DRUG: 10% provodine-iodine vaginal preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Faster Elimination of HPV Infection and Cervical Cancer Using Concomitant HPV Vaccination and HPV Screening: A Demonstration Project in Rwanda
Status: NOT_YET_RECRUITING
Conditions: Cervical Cancer
Interventions: BIOLOGICAL: Gardasil 9
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: High-flow Nasal Cannula Therapy for Stable Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DEVICE: High-flow nasal cannula therapy|DEVICE: Home oxygen therapy (HOT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of Irinotecan Hydrochloride (Campto(R)) And Cisplatin Versus Etoposide And Cisplatin In Small Cell Lung Cancer
Status: COMPLETED
Conditions: Small Cell Lung Carcinoma
Interventions: DRUG: Etoposide + cisplatin|DRUG: Irinotecan + cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Find Out if Fezolinetant Helps Reduce Moderate to Severe Hot Flashes in Women Going Through Menopause
Status: COMPLETED
Conditions: Hot Flashes
Interventions: DRUG: fezolinetant|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy
Status: COMPLETED
Conditions: Bile Acid Malabsorption|Cholelithiasis
Interventions: DRUG: chenodeoxycholic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Effectiveness and Tolerance of Tetracosactide Synacthen® in the Treatment of Post Dural Puncture Headaches (ESYBRECHE)
Status: TERMINATED
Conditions: Post-dural Puncture Headache
Interventions: DRUG: Tetracosactide (Synacthène®)|DRUG: placebo saline (0.9% NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Individualized Nutrition to Optimize Preterm Infant Growth and Neurodevelopment
Status: RECRUITING
Conditions: Very Preterm Maturity of Infant|Very Low Birth Weight Infant
Interventions: DIETARY_SUPPLEMENT: Standardized Fortification|DIETARY_SUPPLEMENT: Adjustable Fortification|DIETARY_SUPPLEMENT: Adjustable Fortification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Physical Activity With or Without Dexamethasone in Reducing Cancer-Related Fatigue in Patients With Locally Advanced, Metastatic, or Recurrent Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Hematopoietic and Lymphoid System Neoplasm|Locally Advanced Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm|Recurrent Malignant Solid Neoplasm
Interventions: DRUG: Dexamethasone|BEHAVIORAL: Exercise Intervention|OTHER: Placebo Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: First-line Chemotherapy Followed by Toripalimab Combined With Anlotinib for Maintenance in ES-SCLC
Status: UNKNOWN
Conditions: Small Cell Lung Carcinoma
Interventions: DRUG: Etoposide Injection|DRUG: Carboplatin Injection|DRUG: Cisplatin injection|DRUG: Toripalimab|DRUG: Anlotinib hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of DSM 32444 Postbiotic in the Treatment of Acute Rhinosinusitis
Status: COMPLETED
Conditions: Rhinosinusitis|Rhinitis
Interventions: DRUG: Neomycin/ Dexameythasone/Xylometazoline|COMBINATION_PRODUCT: Bacillus subtilis DSM32444
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of CES in New Mothers During the Post Partum Period
Status: TERMINATED
Conditions: Anxiety|Depression|Insomnia|Sleep Quality
Interventions: DEVICE: Alpha-Stim AID CES (Active Comparator)|DEVICE: Alpha-Stim AID CES (Sham Comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Capivasertib in Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
Interventions: DRUG: Capivasertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Maintenance Repetitive Transcranial Magnetic Stimulation (rTMS) in Auditory Verbal Hallucinations
Status: NOT_YET_RECRUITING
Conditions: Schizophrenia; Psychosis
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment|DEVICE: Sham Repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of AZD0530 (Saracatinib) in Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: saracatinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Absorption, Metabolism, and Excretion of [14C]-Ecopipam in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: [14C]-Ecopipam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fungal Prophylaxis With Isavuconazole for Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant (HCT)
Status: COMPLETED
Conditions: Hematologic Malignancy|Myeloproliferative Disorder
Interventions: DRUG: Isavuconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Typhax, a Typhoid Vaccine
Status: COMPLETED
Conditions: Typhoid Fever
Interventions: BIOLOGICAL: Typhax (investigational typhoid fever candidate vaccine)|BIOLOGICAL: Placebo|BIOLOGICAL: Active Comparator Typhim Vi
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Timing of Delivery in Fetal Growth Restriction of Uncomplicated Women
Status: COMPLETED
Conditions: Fetal Growth Restriction
Interventions: PROCEDURE: Labor induction at 37.0 to 37.6 weeks of gestation|PROCEDURE: Expectant monitoring until delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rollover Study for Subjects Who Have Participated in an Astellas Sponsored ASP2215 Trial
Status: COMPLETED
Conditions: Advanced Solid Tumors|Acute Myeloid Leukemia
Interventions: DRUG: Gilteritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effects of Pelvic Alignment Versus Diaphragmatic Breathing on Shoulder Range of Motion
Status: UNKNOWN
Conditions: Glenohumeral Internal Rotation Deficit|Pelvic Misalignment|Diaphragmatic Breathing
Interventions: OTHER: Pelvic alignment and forceful expiration|OTHER: Pelvic repositioning exercise|OTHER: Diaphragmatic breathing exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Different Reversal Agents in Pediatric Day-case Cancer Surgery
Status: UNKNOWN
Conditions: Post-operative Residual Curarization
Interventions: DRUG: Sugammadex Injection [Bridion]|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Pilot to Evaluate the Feasibility and Efficacy of a Multifaceted Rehabilitation Intervention
Status: COMPLETED
Conditions: Mobility Limitation
Interventions: OTHER: InVEST: Increased Velocity Exercise Specific to Task|OTHER: TAPAT: Tonic and Phasic Alertness Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Fluoroglutamine PET/CT in Imaging Patients With Malignant Tumor
Status: UNKNOWN
Conditions: Cancer|Metastatic Cancer|Metastatic Brain Cancer
Interventions: RADIATION: 18F-(2S,4R)4-fluoroglutamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Testing Two Models of PrEP Delivery in OBGYN Clinics
Status: ACTIVE_NOT_RECRUITING
Conditions: Hiv
Interventions: OTHER: NP-PC PrEP|OTHER: OBGYN-PrEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE