pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect on Bronchodilation Response and Ventilation Heterogeneity of Different Inhalation Volumes in COPD
Status: NOT_YET_RECRUITING
Conditions: COPD|Lung Injury
Interventions: OTHER: Inhalation of bronchodilation therapy at FRC|OTHER: Inhalation of bronchodilation therapy at RV
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy And Safety Of Combination Therapy For Treatment Of Overactive Bladder In Male Patients With Benign Prostatic Hyperplasia.
Status: UNKNOWN
Conditions: Overactive Bladder|Benign Prostatic Hyperplasia
Interventions: DRUG: Mirabegron|DRUG: Tamsulosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of Pasireotide (SOM230) in Patients With Advanced Neuroendocrine Tumors (NETs)
Status: COMPLETED
Conditions: Neuroendocrine Tumors
Interventions: DRUG: Pasireotide LAR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study to Evaluate IOP Lowering Therapy in Open Angle Glaucoma and Ocular Hypertension C-01-69
Status: COMPLETED
Conditions: Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Alcon Investigational Agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Yohimbine Treatment for Type 2 Diabetes Patients Carrying a Specific Genetic Risk Variant
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Yohimbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity & Safety of Hepatitis A Vaccine Co-admin With a Measles/Mumps/Rubella & a Varicella Vaccine in Children
Status: COMPLETED
Conditions: Hepatitis A
Interventions: BIOLOGICAL: Havrix®|BIOLOGICAL: M-M-R®II|BIOLOGICAL: VARIVAX®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Investigation to Evaluate the Performance of Hyaluronic Acid for the Treatment of Hypertrophic Scars
Status: RECRUITING
Conditions: Hypertrophic Scar
Interventions: DEVICE: Autocrosslinked Hyaluronic aid|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fucosylated T Cells for Graft Versus Host Disease (GVHD) Prevention
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: DRUG: Rituximab|DRUG: Fludarabine|DRUG: Cyclophosphamide|RADIATION: Total Body Radiation|PROCEDURE: Fucosylated Regulatory T Cells|PROCEDURE: Cord Blood Infusions|DRUG: Mycophenolate mofetil|DRUG: Sirolimus|PROCEDURE: Bone Marrow Aspiration|DRUG: G-CSF|PROCEDURE: Non-Fucosylated Regulatory T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Stepped Care Model of Adolescent Depression Treatment in Primary Care
Status: COMPLETED
Conditions: Major Depressive Disorder|Dysthymia
Interventions: BEHAVIORAL: Stepped Care IPT-A (SCIPT-A)|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer
Status: COMPLETED
Conditions: Childhood Germ Cell Tumor|Extragonadal Germ Cell Tumor|Head and Neck Cancer|Kidney Cancer|Liver Cancer|Lymphoma|Neuroblastoma|Ovarian Cancer|Retinoblastoma|Sarcoma|Testicular Germ Cell Tumor
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: thiotepa|DRUG: topotecan hydrochloride|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: in vitro-treated bone marrow transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen Therapy for Acute Domestic Carbon Monoxide (CO) Poisoning
Status: TERMINATED
Conditions: Carbon Monoxide Poisoning
Interventions: OTHER: normobaric oxygen therapy|OTHER: Hyperbaric oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Evaluation of Cellavita HD Administered Intravenously in Participants With Huntington's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Huntington Disease
Interventions: BIOLOGICAL: Cellavita HD Lower Dose|BIOLOGICAL: Cellavita HD Higher dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Double-blind, Placebo-controlled, Single-dose Study to Evaluate the PK, IM, and Safety in Japanese Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: 100mg Mavrilimumab|DRUG: 150mg mavrilimumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label Study to Investigate the Absorption, Metabolism and Excretion of Radiolabeled PD 0332334 in Six Healthy Male Volunteers
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: DRUG: PD 0332334
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Use of Renin Versus Lactic Acid as Tissue Perfusion Biomarkers for Mortality Prediction in Hypotensive Critically Ill Patients
Status: RECRUITING
Conditions: Sepsis|Obstructive Shock|Critical Illness|Hypotensive|Critically Ill
Interventions: DIAGNOSTIC_TEST: Renin levels and lactic acid levels
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma
Status: COMPLETED
Conditions: Childhood Malignant Fibrous Histiocytoma of Bone|Sarcoma
Interventions: DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Parenteral Nutrition-Associated Cholestasis With Cyclic Parenteral Nutrition in Infants
Status: TERMINATED
Conditions: Cholestasis|Prematurity|Gastroschisis|Intestinal Atresia|Necrotizing Enterocolitis
Interventions: DIETARY_SUPPLEMENT: Parenteral Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial of Vorinostat in Combination With Cyclophosphamide, Etoposide, Prednisone and Rituximab for Elderly Patients With Relapsed Diffuse Large B-Cell Lymphoma (DLBCL)
Status: COMPLETED
Conditions: Hodgkin's Disease|Lymphoma
Interventions: DRUG: rituximab, cyclophosphamide, etoposide, prednisone, vorinostat and QOL questionnaire, peg-filgrastim or filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Serratus Plane Block Associated With Sedation in Axillary Dissection
Status: COMPLETED
Conditions: Anesthesia|Regional Anesthesia Morbidity|Axillary Metastases|Nerve Block|Analgesia|Skin Cancer
Interventions: PROCEDURE: Serratus plane block|PROCEDURE: Axillary dissection|PROCEDURE: Intravenous sedation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PrEP-Pod-IVR (TDF-FTC/Placebo IVR 28 Day Crossover Study)
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Prevention
Interventions: DRUG: Tenofovir Disoproxil Fumarate (TDF)-Emtricitabine (FTC)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Response Adapted Incorporation of Tislelizumab Into the Front-line Treatment of Older Patients With Hodgkin lYmphoma
Status: NOT_YET_RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: DRUG: Tislelizumab, AVD, Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Updating Deep Learning Algorithms for OSA Monitoring
Status: RECRUITING
Conditions: Obstructive Sleep Apnea|Obstructive Sleep Apnea-hypopnea
Interventions: DEVICE: CART-I plus|DEVICE: Polysomnography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: VALORY Study of Valsartan/Hydrochlorizide for Patients Who do Not Respond Adequately to Olmesartan Medoxomil
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: valsartan plus hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib/Erlotinib Versus Erlotinib Alone in Previously Treated Advanced Non-Small-Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Erlotinib + Sorafenib|DRUG: Erlotinib + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Center, Single Arm Clinical Study on the Treatment of Advanced Non-small Cell Lung Cancer With Positive EGFR Sensitive Mutations and Failed EGFR TKIs With the Combination of Enrotinib and Paclitaxel Monoclonal Antibody
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer|TKI Resistance|EGFR Sensitive Mutation|Anlotinib|Pianzumab
Interventions: DRUG: Anlotinib|DRUG: Penpulimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Research of the Cerebral Protection Effects of Electroencephalogram (SedLine) During Carotid Endarterectomy
Status: UNKNOWN
Conditions: Transient Ischemic Attack|Acute Stroke|Postoperative Delirium|Postoperative Cognitive Dysfunction
Interventions: COMBINATION_PRODUCT: Anesthesia level and cerebral perfusion pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Neural Mobilization With or Without Soft Tissue Mobilization in Cervical Radiculopathy
Status: UNKNOWN
Conditions: Cervical Radiculopathy
Interventions: OTHER: Neural Mobilization with Soft Tissue Mobilization|OTHER: Neural Mobilization without Soft Tissue Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Specification Clinical Application Research of Tripterygium Wilfordii Treating Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Treatment of MTX and TwHF placebo|DRUG: Treatment of TwHF and MTX placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2a Evaluation of PLN-74809 on αvβ6 Receptor Occupancy Using PET Imaging in Participants With IPF/
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: PLN-74809|RADIATION: Knottin tracer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Naxitamab and Granulocyte-Macrophage Colony Stimulating Factor (GMCSF) and Isotretinoin for Consolidation of Patients With High-Risk Neuroblastoma in First Remission.
Status: WITHDRAWN
Conditions: Neuroblastoma
Interventions: DRUG: Naxitamab|DRUG: GM-CSF|DRUG: Isotretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Endoscopic Injection of Fibrin Sealant Versus Endoscopic Ligature for Bleeding Esophageal Varices
Status: COMPLETED
Conditions: Esophageal and/or Gastric Varices
Interventions: DRUG: Fibrin Sealant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Advance Gastric Cancer With Disulfiram
Status: NOT_YET_RECRUITING
Conditions: Chemotherapy；Advanced Gastric Cancer；Cisplatin；Disulfiram
Interventions: DRUG: disulfiram and cisplatin|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALknee Follow-up Study of the Cementless ATTUNE Rotating Platform and the Cementless LCS Rotating Platform Knee System
Status: ACTIVE_NOT_RECRUITING
Conditions: Total Knee Arthroplasty|Total Knee Replacement|Knee Osteoarthritis
Interventions: RADIATION: Radiographs of the knee for radiostereometric analysis (RSA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trametinib and Akt Inhibitor GSK2141795 in Treating Patients With Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Recurrent Adult Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: Akt Inhibitor GSK2141795|OTHER: Laboratory Biomarker Analysis|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HR+/HER2- Advanced Breast Cancer and Endocrine Resistance
Status: TERMINATED
Conditions: Breast Cancer Metastatic
Interventions: DRUG: Palbociclib|DRUG: Fulvestrant|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intratracheal Budesonide/Surfactant Prevents BPD
Status: COMPLETED
Conditions: Respiratory Distress Syndrome|Bronchopulmonary Dysplasia
Interventions: DRUG: budesonide|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Detection of Amyloidosis in Multiple Myeloma Patients by [18F]Florbetaben Positron Emission Tomography
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: [18F]Florbetaben
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bupivicaine to Reduce Postoperative Pain in Laparoscopic Ventral Hernia Repair
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Bupivicaine Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Exercises Training in Patients With Mild Cognitive Impairment and Early Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: OTHER: Aerobic exercises|OTHER: Stretch exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Skin Cancer in High Risk Patients After Conversion to a Sirolimus-based Immunosuppressive Protocol
Status: TERMINATED
Conditions: Renal Transplant Patients at High-risk for Skin Cancer
Interventions: DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Protein-energy Enriched Milk for Infants With Bronchiolitis
Status: UNKNOWN
Conditions: Bronchiolitis
Interventions: DIETARY_SUPPLEMENT: Infatrini® or Infatrini Peptisorb®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sildenafil in Sever Intrauterine Growth Retardation
Status: COMPLETED
Conditions: Intra-Uterine Growth Retardation
Interventions: OTHER: treatment|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Comparison Study of Standard Care Against Combination of Growth Factors Agents for Low-risk Myelodysplastic Syndromes
Status: UNKNOWN
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: Darbepoetin alpha|DRUG: Filgrastim|PROCEDURE: Blood Red Cell Transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose:
Clinical trial: Comparison of Intracoronary Versus Intravenous Abciximab in ST-segment Elevation Myocardial Infarction (CICERO)
Status: UNKNOWN
Conditions: ST-Elevation Myocardial Infarction
Interventions: DRUG: abciximab|DRUG: abciximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cobiprostone for the Prevention of Oral Mucositis in Subjects With Head and Neck Cancer Receiving Concurrent Radiation and Chemotherapy
Status: TERMINATED
Conditions: Oral Mucositis
Interventions: DRUG: Cobiprostone|DRUG: Placebo|DRUG: Standard Care - Chemotherapy|RADIATION: Standard Care - Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Reduction of Bladder Injection Pain With Belladonna Opiate Suppository
Status: COMPLETED
Conditions: Overactive Bladder|Urinary Urge Incontinence|Urinary Bladder, Neurogenic|Painful Bladder Syndrome
Interventions: DRUG: Onabotulinumtoxin A (BoNT)|DRUG: belladonna|DRUG: Morphine|DRUG: Placebo|DRUG: Active B&O suppository of belladonna
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Single and Multiple Ascending Dose Study of CK-3828136 in Healthy Adult Participants
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: CK-3828136|DRUG: Placebo for CK-3828136
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Pembrolizumab With Single Agent Chemotherapy in Elderly Patients With Advanced NSCLC
Status: WITHDRAWN
Conditions: Non Small Cell Lung Cancer|Advanced Lung Non-Small Cell Carcinoma|PD-L1 Gene Mutation
Interventions: DRUG: Pembrolizumab|DRUG: Pemetrexed|DRUG: Paclitaxel|DRUG: Nab-paclitaxel|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 90Y-labelled Anti-CD66 ab in Childhood High Risk Leukaemia
Status: RECRUITING
Conditions: Leukemia
Interventions: DRUG: 90-Yttrium-labelled anti-CD66 monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinico-biological Collection to Investigate the Physiopathology of Systemic Autoimmune Diseases
Status: RECRUITING
Conditions: Lupus Erythematosus|Scleroderma|Myositis|Vasculitis|Inflammatory Bowel Diseases
Interventions: BIOLOGICAL: Blood sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dulce Digital-COVID Aware (DD-CA) Discharge Texting Platform for US/Mexico Border Hispanics With Diabetes + COVID-19
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Covid19
Interventions: BEHAVIORAL: Hospital: DD-CA|BEHAVIORAL: Hospital: Usual Care (UC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Evaluate Whether IVUS-guided Drug-eluting Stent (DES) Implantation Leads to Better Clinical Outcomes Compared to Conventional Angiography in the Treatment of Chronic Complete Occlusion (CTO) Disease.
Status: RECRUITING
Conditions: Chronic Total Occlusion of Coronary Artery
Interventions: PROCEDURE: The guidewire successfully passed the CTO lesion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Use of Evicel to Reduce Blood Loss in Total Knee Replacement Surgery
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Evicel fibrin sealant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia
Status: COMPLETED
Conditions: Adult Acute Lymphoblastic Leukemia|Adult Acute Myeloid Leukemia|Adult Burkitt Lymphoma|Adult Diffuse Large Cell Lymphoma|Adult Diffuse Mixed Cell Lymphoma|Adult Diffuse Small Cleaved Cell Lymphoma|Adult Hodgkin Lymphoma|Adult Immunoblastic Large Cell Lymphoma|Adult Lymphoblastic Lymphoma|Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative|Breast Cancer|Chronic Eosinophilic Leukemia|Chronic Lymphocytic Leukemia|Chronic Myelogenous Leukemia|Chronic Myelomonocytic Leukemia|Chronic Neutrophilic Leukemia|Cutaneous T-cell Non-Hodgkin Lymphoma|Disseminated Neuroblastoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Grade 1 Follicular Lymphoma|Grade 2 Follicular Lymphoma|Grade 3 Follicular Lymphoma|Malignant Testicular Germ Cell Tumor|Mantle Cell Lymphoma|Marginal Zone Lymphoma|Multiple Myeloma|Mycosis Fungoides/Sezary Syndrome|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Neutropenia|Nodal Marginal Zone B-cell Lymphoma|Ovarian Epithelial Cancer|Ovarian Germ Cell Tumor|Plasma Cell Neoplasm|Poor Prognosis Metastatic Gestational Trophoblastic Tumor|Primary Myelofibrosis|Prolymphocytic Leukemia|Small Lymphocytic Lymphoma|Splenic Marginal Zone Lymphoma
Interventions: DRUG: cefepime hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thoracic Paravertebral Blocks Using a Combination of Ropivacaine and Dexmedetomidine
Status: WITHDRAWN
Conditions: Thoracic Paravertebral Blocks
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Prior to TKI to Delay Progression in Advanced Driver-Mutated Non-small Cell Lung Cancers (RadiaNCe Lung X)
Status: NOT_YET_RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DEVICE: Radiation Therapy|DRUG: Targeted TKI therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of APL-1501 Extended Release (ER) Capsules Compared to APL-1202 Immediate Release (IR) Tablets in Healthy Volunteers
Status: NOT_YET_RECRUITING
Conditions: Bladder Cancer
Interventions: DRUG: APL-1202 and APL-1501 (Single ascending dose)|DRUG: APL-1202 and APL-1501 (Multiple Ascending dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Treatment of Psycho-stimulant and Cannabis-dependent Users in Israel
Status: UNKNOWN
Conditions: Cannabis Dependence|Psychostimulant Dependence
Interventions: DRUG: Risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk Stratification of Heart Failure in Cardiomyopathies.
Status: COMPLETED
Conditions: Cardiomyopathy With Unknown Etiology
Interventions: DRUG: etiologic treatment,anti-myocardial remodeling|DRUG: anti-myocardial remodeling|DRUG: anti-myocardial remodeling,anti-acute heart failure|DRUG: Etiological, anti-remodeling and symptom treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Lay Fieldworker Led School Health Program for Rural Primary Schools
Status: COMPLETED
Conditions: Health Promotion|Diarrhea
Interventions: BEHAVIORAL: Comprehensive Health & Hygiene Improvement Program (CHHIP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Enhancing Frontal Lobes Plasticity in Mild Cognitive Impairment
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Memory Impairment
Interventions: DEVICE: Paired Associative Stimulation (PAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of E7090 in Participants With Unresectable Advanced or Metastatic Cholangiocarcinoma With Fibroblast Growth Factor Receptor (FGFR) 2 Gene Fusion
Status: ACTIVE_NOT_RECRUITING
Conditions: Cholangiocarcinoma
Interventions: DRUG: E7090
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Insulin Sensitizers in Subjects With Impaired Glucose Tolerance
Status: COMPLETED
Conditions: Glucose Metabolism Disorders|Diabetes
Interventions: DRUG: Metformin|DRUG: Pioglitazone|DRUG: Metformin|DRUG: Pioglitazone|RADIATION: CT scans|PROCEDURE: Oral glucose tolerance test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: EPIC US Feasibility Study: Use of the FiberNet® Emboli Protection Device in Carotid Artery Stenting
Status: COMPLETED
Conditions: Carotid Artery Stenosis
Interventions: DEVICE: FiberNet Emboli Protection System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Safety and Efficacy Trial to Evaluate the Hydrus(TM) Implant in Subjects Undergoing Cataract Surgery.
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma|Glaucoma, Open Angle, Pseudo-exfoliative|Cataract Unilateral Pending Extraction
Interventions: DEVICE: Hydrus Implant|PROCEDURE: IOL placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Gender Differences in Switching From Smoking Regular Cigarettes to E-Cigarettes
Status: RECRUITING
Conditions: Cigarette Smoking-Related Carcinoma
Interventions: DRUG: Nicotine Replacement|OTHER: Questionnaire Administration|DEVICE: Electronic Cigarette|DEVICE: Electronic Cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Medacta Quadra-P Anteverted Study
Status: RECRUITING
Conditions: Arthrosis|Traumatic Arthritis|Rheumatoid Polyarthritis|Congenital Hip Dysplasia|Avascular Necrosis of the Femoral Head
Interventions: DEVICE: Quadra P anteverted
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Shortened Regimen for Drug-susceptible TB in Children
Status: NOT_YET_RECRUITING
Conditions: Tuberculosis|Tuberculosis, Pulmonary|Tuberculosis, Lymph Node|Mycobacterium Tuberculosis
Interventions: DRUG: Isoniazid|DRUG: Rifampin|DRUG: Pyrazinamide|DRUG: Ethambutol|DRUG: Rifapentine|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correlation of Measured and Calculated Serum Osmolality During Hyperosmolar Drugs Infusion in Patients After Craniotomy
Status: COMPLETED
Conditions: Brain Edema
Interventions: DRUG: 20% mannitol solution, 125 ml, IV infusion in 15 min|DRUG: 3.1% sodium chloride solution, 125 ml, IV infusion in 15 min
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Lidocaine-Prilocaine (EMLA) Cream as Analgesia in Hysteroscopy Practice
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: lidocaine-prilocaine cream|OTHER: gel application for the transmission of ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Side Effects of the mGlu5 Antagonist Fenobam in Adult Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Fenobam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Cladribine in Combination With CAG in Patients With Refractory/Relapsed Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia|Relapse Leukemia
Interventions: DRUG: Cladribine|DRUG: G-CSF|DRUG: Aclarubicin|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimedia Psychoeducation or Print Education in Preparing Cancer Patients for Decision Making About Clinical Trials
Status: COMPLETED
Conditions: Malignant Neoplasm
Interventions: BEHAVIORAL: print educational intervention|BEHAVIORAL: multimedia psychoeducational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Remazolam on Hemodynamics During Hepatectomy
Status: NOT_YET_RECRUITING
Conditions: Hemodynamic Instability
Interventions: DRUG: Remimazolam|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Preventing ESRD in Overt Nephropathy of Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: Benazepril|DRUG: Valsartan|DRUG: Benazepril/Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in Healthy Subjects, Patients With Urea Cycle Disorders (UCD) and Carriers of UCD Mutations to Evaluate Urea Cycle Function
Status: COMPLETED
Conditions: Urea Cycle Disorders
Interventions: OTHER: oral administration of Sodium [1,2-13C]-Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ibrutinib for the Treatment of Patients With B-Cell Malignancies Who Are Infected With Coronavirus Disease 2019 (COVID-19)
Status: WITHDRAWN
Conditions: Asymptomatic COVID-19 Infection Laboratory-Confirmed|B-Cell Neoplasm|Chronic Lymphocytic Leukemia|Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma|Mantle Cell Lymphoma|Marginal Zone Lymphoma|Small Lymphocytic Lymphoma|Symptomatic COVID-19 Infection Laboratory-Confirmed|Waldenstrom Macroglobulinemia
Interventions: DRUG: Ibrutinib|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Applicability of Uroflowmetry in Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Lower Urinary Tract Symptoms
Interventions: DEVICE: uroflow measurement|DEVICE: Bladder ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Combination Chemotherapy With or Without Cetuximab as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: capecitabine|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flupirtine as Oral Treatment in Multiple Sclerosis
Status: TERMINATED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: Flupirtine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of the Histidine Rich Protein 2 (HRP2) Highly Sensitive Rapid Diagnostic Test (HS-RDT) for Malaria Diagnosis in Pregnant Women in Papua New Guinea
Status: UNKNOWN
Conditions: Plasmodium Falciparum Malaria|Pregnancy Malaria|Diagnoses Disease
Interventions: DIAGNOSTIC_TEST: HS-RDT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TAP Block: Does Volume Make a Difference?
Status: COMPLETED
Conditions: Post-operative Pain
Interventions: DRUG: Ropivacaine|DRUG: Ropivacaine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Misoprostol Administration Before Operative Hysteroscopy
Status: COMPLETED
Conditions: Endometrial Disorder
Interventions: DRUG: Oral misoprostol|DRUG: Sublingual misoprostol|DRUG: Vaginal misoprostol|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Two-Dose Level Evaluation of NX-1207 for the Treatment of Low Risk, Localized (T1c) Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: NX-1207 2.5 mg|DRUG: NX-1207 15 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phenylephrine and Hypotension During Spinal Anesthesia for Cesarean Section
Status: COMPLETED
Conditions: Anesthesia, Obstetrical|Anesthesia, Spinal
Interventions: DRUG: Phenylephrine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multicenter Study Comparing OsseoSpeed TX With OsseoSpeed EV.
Status: COMPLETED
Conditions: Partial Edentulism in the Maxilla or in the Mandible
Interventions: DEVICE: OsseoSpeed EV|DEVICE: OsseoSpeed TX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid Diagnostic Testing and Artemisinin-Based Combination Therapy for Uncomplicated Malaria by Community Health Workers
Status: COMPLETED
Conditions: Uncomplicated Plasmodium Falciparum Malaria
Interventions: DEVICE: Rapid diagnostic test for malaria
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Enteral Nutrition After Pancreaticoduodenectomy
Status: COMPLETED
Conditions: Cancer of Pancreas|Cancer of Duodenum|Ampulla of Vater Cancer|Cholangiocarcinoma
Interventions: OTHER: Early enteral nutrition|OTHER: Saline|DEVICE: nasojejunal tube insertion|OTHER: Oral intake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety of DA-3030 and to Explore the Efficacy for Diabetic Neuropathic Pain
Status: COMPLETED
Conditions: Diabetic Neuropathy
Interventions: DRUG: 600㎍ of DA-3030 Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Pancreatitis: the Role of Supportive and Drainage Treatment
Status: UNKNOWN
Conditions: Pancreatitis
Interventions: PROCEDURE: Percutaneous catheter drainage|PROCEDURE: Abdominal paracentesis evacuation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quadratus Lumborum Block Reduced Postpartum Uterine Pain After Virginal Childbirth
Status: COMPLETED
Conditions: Quadratus Lumborum Nerve Block|Postpartum Cramping|Vaginal Delivery
Interventions: PROCEDURE: quadratus lumborum nerve block (ropivacaine )|PROCEDURE: quadratus lumborum nerve block (normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of an Attention-based Intervention for School Aged Autistic Children With Anger Regulating Problems
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Anger can go!|BEHAVIORAL: Parent psycho-education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Reuteri DSM17938 in C-Section Infants
Status: COMPLETED
Conditions: C-section
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri DSM17038|OTHER: Placebo for Probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Epinephrine Infusion for Prophylaxis Against Maternal Hypotension After Spinal Anesthesia for Cesarean Delivery
Status: COMPLETED
Conditions: Hypotension During Surgery
Interventions: DRUG: Phenylephrine|DRUG: Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Protein Quality on Post-exercise Skeletal Muscle and Whole-body Protein Kinetics During Energy Deficit
Status: COMPLETED
Conditions: Whole-body Protein Balance|Muscle Protein Synthesis
Interventions: DIETARY_SUPPLEMENT: Essential Amino Acid Enriched Whey Protein|DIETARY_SUPPLEMENT: Whey Protein|DIETARY_SUPPLEMENT: Military Ration Entree
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gynaecological Speculum Examination: Straight Horizontal Insertion Versus Vertical Insertion and Rotation.
Status: COMPLETED
Conditions: Vaginal Speculum Examination
Interventions: OTHER: Type of speculum vaginal insertion method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Bifocal Spectacles vs. Single Vision Spectacles for Esotropia Greater at Near
Status: NOT_YET_RECRUITING
Conditions: Esotropia
Interventions: DEVICE: Bifocal Spectacles|DEVICE: Single Vision Lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Enzalutamide Dose Reduction on Fatigue, Cognition, and Drug Trough Levels in Patients With Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Low Dose Remifentanil Infusion During Tracheal Extubation in Surgical Intensive Care Unit Patients
Status: COMPLETED
Conditions: Tracheal Extubation
Interventions: DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Transcutaneous and Epidural Spinal Stimulation for Improving Function
Status: WITHDRAWN
Conditions: Spinal Cord Injuries|Spinal Cord Diseases|Central Nervous System Diseases|Nervous System Diseases|Trauma, Nervous System|Wounds and Injuries
Interventions: DEVICE: Transcutaneous spinal stimulation|DEVICE: Epidural spinal stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Olopatadine 0.6% and Azelastine 137 Mcg in Vasomotor Rhinitis
Status: COMPLETED
Conditions: Vasomotor Rhinitis
Interventions: DRUG: Olopatadine HCL (Patanase) Nasal Spray, 0.6%|DRUG: Azelastine HCl (Astelin) Nasal Spray, 137 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultraviolet (UVA and UVB) Light Therapy in the Treatment of Inflammatory Skin Conditions
Status: TERMINATED
Conditions: Atopic Dermatitis|Psoriasis|Alopecia|Mycosis Fungoides|Urticaria|Dermatoses|Stretch Marks
Interventions: PROCEDURE: UVA1 Irradiation|PROCEDURE: UVB Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study Of PF-00868554 In Hepatitis C Virus (HCV) Positive Patients
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: PF-00868554|DRUG: PF-00868554|DRUG: PF-00868554|DRUG: PF-00868554|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effects of Cenicriviroc Mesylate on Arterial Inflammation in People Living With HIV
Status: WITHDRAWN
Conditions: HIV Infections
Interventions: DRUG: Cenicriviroc Mesylate (CVC)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bezlotoxumab Yielded Outcomes by Addressing Personalized Needs in Clostridioides Difficile Infection
Status: COMPLETED
Conditions: Clostridioides Difficile Infection|Stool Microbiome|Organ Dysfunction Syndrome|Clostridioides Difficile Infection Recurrence|Mortality
Interventions: DRUG: Bezlotoxumab|DRUG: Normal saline 0.9% or 5% dextrose water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Two Vitamin D Dosing Strategies in Children With Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: 1000 IU of Vitamin D3|DRUG: 4000 IU of Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Transanal Decompression Tube Placement After Colorectal Anastomosis: A Randomized Trial
Status: UNKNOWN
Conditions: Colorectal Cancer|Postoperative Complications|Anastomotic Leak|Anastomotic Complication
Interventions: PROCEDURE: Intraoperative transanal decompression tube placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: phenotypeS in Non Ambulant Duchenne Muscular Dystrophy
Status: RECRUITING
Conditions: Duchenne Muscular Dystrophy|Natural History|Motor Function; Retardation
Interventions: OTHER: Different Phenotypes of non ambulant patients with Duchenne Muscular Dystrophy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Red Beetroot Juice on High-Fat Meal-Induced Endothelial Dysfunction and Cardiometabolic Disturbances
Status: UNKNOWN
Conditions: Overweight|Obesity|Aging|Menopause
Interventions: DIETARY_SUPPLEMENT: 70 mL red beetroot juice|DIETARY_SUPPLEMENT: 70 mL red beetroot juice without nitrate|DIETARY_SUPPLEMENT: 70 mL placebo drink plus potassium nitrate|DIETARY_SUPPLEMENT: 70 mL placebo drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intratumor Injection of Anti-Mesothelin Immunotoxin LMB-100 With Ipilimumab in Malignant Mesothelioma
Status: TERMINATED
Conditions: Mesothelioma
Interventions: BIOLOGICAL: LMB-100|DRUG: ipilimumab|DRUG: Diphenhydramine|DRUG: Famotidine|DRUG: Acetaminophen|DRUG: Dexamethasone|PROCEDURE: Biopsy|DIAGNOSTIC_TEST: FDG-PET|DIAGNOSTIC_TEST: CT CAP|DIAGNOSTIC_TEST: MRI|DIAGNOSTIC_TEST: ECG|DIAGNOSTIC_TEST: Echocardiogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Trial With S 44819 After Recent Ischemic Cerebral Event
Status: COMPLETED
Conditions: Post Stroke Recovery
Interventions: DRUG: S 44819 150 mg twice a day|DRUG: S 44819 300 mg twice a day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cisplatin/Paclitaxel/Gemcitabine +/- Avastin in Patients With Unknown Primary Tumor
Status: WITHDRAWN
Conditions: Unknown Primary Tumors
Interventions: DRUG: Cisplatin|DRUG: Paclitaxel|DRUG: Gemcitabine|DRUG: Avastin (Bevacizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patients With Epilepsy Taking LAMICTAL Immediate-Release Who Switch To Extended-Release Formulation And Vice Versa
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: lamotrigine extended-release
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation (tDCS) for Treatment-Resistant Obsessive-Compulsive Disorder (FRONT)
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: Active tDCS (transcranial direct current stimulation)|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT