pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of H7N9 Influenza Vaccine (AT-501) in Healthy Adult Subjects
Status: COMPLETED
Conditions: H7N9 Influenza Vaccine
Interventions: BIOLOGICAL: AT-501 High Dose vaccine|BIOLOGICAL: AT-501 High Dose vaccine with Adjuvant|BIOLOGICAL: AT-501 Low Dose vaccine|BIOLOGICAL: AT-501 Low Dose vaccine with Adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Narrow Band Imaging Versus White Light for the Detection and Miss of Sessile Serrated Lesion
Status: RECRUITING
Conditions: Colorectal Sessile Serrated Lesion
Interventions: PROCEDURE: WLI Then NBI Withdrawal|PROCEDURE: NBI Then WLI Withdrawal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: STOP-MSU: Stopping Haemorrhage With Tranexamic Acid for Hyperacute Onset Presentation Including Mobile Stroke Units
Status: COMPLETED
Conditions: Intracerebral Haemorrhage
Interventions: DRUG: Tranexamic Acid|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of AST-120 in Patients With Non-Constipating Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: AST-120|DRUG: Celphere® CP-305
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Riluzole in Surgical Treatment for Cervical Spondylotic Myelopathy (CSM-Protect)
Status: COMPLETED
Conditions: Cervical Spondylotic Myelopathy
Interventions: DRUG: riluzole|DRUG: Placebo medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diclophenac Versus Placebo for Pain Control in Diagnostic Colonoscopy
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: diclophenac sodium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reduction of Inappropriate Implantable Cardioverter Defibrillator (ICD) Therapies in Primary Prevention Patients
Status: COMPLETED
Conditions: Cardiac Death
Interventions: DEVICE: device settings for group A|DEVICE: Device settings for group B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoxygenation in the Intensive Care Unit Using a Nose-mouth Mask Versus High-flow Nasal Cannula Oxygen.
Status: COMPLETED
Conditions: Respiratory Failure
Interventions: DEVICE: Nose-mouth mask|DEVICE: High flow nasal cannula oxygen|PROCEDURE: Intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Matrix Metalloproteinases Expression in the Neointimal Hyperplasia Induced by Drug Eluting Stent (DES) Implantation
Status: UNKNOWN
Conditions: Coronary Artery Disease|Stent Restenosis
Interventions: DEVICE: DES implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Transversus Abdominis Plane (TAP) Versus Local Anesthetic for Lap Appendectomies
Status: TERMINATED
Conditions: Appendicitis
Interventions: DRUG: Ropivacaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Success Rates of Video- vs. Direct Laryngoscopy for Endotracheal Intubation in Anesthesiology Residents: A Randomized Controlled Trial" (The JuniorDoc-VL-Trial)
Status: RECRUITING
Conditions: Intubation Complication|Intubation
Interventions: DEVICE: video laryngoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Validation of a Simulator-based Test in Transurethral Resection of Bladder Tumors
Status: COMPLETED
Conditions: Validity-evidence for a Simulator-based Test|Virtual Simulation|Bladder Cancer|Surgical Skill Training|Medical Education|Transurethral Resection of Bladdertumors
Interventions: OTHER: Simulation training
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessing the Clinical Utility of tACS
Status: COMPLETED
Conditions: Anxiety Disorders and Symptoms|Sensory Disorders|Hypervigilance|Post Traumatic Stress Disorder
Interventions: DEVICE: Transcranial Alternating Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Role of the Type of Carotid Stent and Cerebral Protection on Cerebral Microembolization During Carotid Artery Stenting. A Randomized Study Comparing Carotid Wallstent vs Roadsaver® Stent and Distal vs Proximal Protection.
Status: UNKNOWN
Conditions: Carotid Stenosis
Interventions: DEVICE: Filterwire EZ™|DEVICE: MO.MA Ultra|DEVICE: Stent Roadsaver®|DEVICE: Carotid Wallstent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comprehensive Management of High-risk PopuLatIon of Stroke Based on Social Network
Status: RECRUITING
Conditions: Stroke|Cerebrovascular Disorders|Brain Diseases|Central Nervous System Diseases|Nervous System Diseases|Vascular Diseases|Cardiovascular Diseases
Interventions: BEHAVIORAL: Post-hospital management based on WeChat applet|BEHAVIORAL: Routine post-hospital follow-up management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: DOTATOC PET/CT for Imaging NET Patients
Status: RECRUITING
Conditions: Neuroendocrine Tumors|Insulinoma|Gastrinoma|Glucagonoma|Vipoma|Pheochromocytoma|Paraganglioma|Neuroblastoma|Ganglioneuroma|Medullary Carcinoma|Pituitary Adenoma|Medulloblastoma|Merkel Cell Carcinoma|Small-cell Lung Cancer|Meningioma|Carcinoid
Interventions: DIAGNOSTIC_TEST: 68Ga-DOTATOC PET/CT|DIAGNOSTIC_TEST: 18F-FDG PET/CT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment III) - 3
Status: WITHDRAWN
Conditions: Heroin Dependence|Opioid-Related Disorders
Interventions: DRUG: Opioid-Related Disorders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: pTVG-HP DNA Vaccine With or Without pTVG-AR DNA Vaccine and Pembrolizumab in Patients With Castration-Resistant, Metastatic Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Castration-resistant Prostate Cancer|Metastatic Cancer|Prostate Cancer
Interventions: BIOLOGICAL: pTVG-HP|BIOLOGICAL: pTVG-AR|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET/CT Assessment of Tumor Perfusion in Patients With Renal Cell Carcinoma
Status: TERMINATED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: 150-Water|DRUG: 62Cu-ethylglyoxal bis|PROCEDURE: Positron Emission Tomography|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Diagnostic Performances of Urine and Plasma 5-hydroxyindolacetic Acid (5HIAA) Values in Patients With Small-intestine Neuroendocrine Tumors
Status: COMPLETED
Conditions: Small-intestine Neuroendocrine Tumors (Carcinoid Tumors)
Interventions: BIOLOGICAL: blood sample withdrawn
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Mometasone Furoate Nasal Spray With the Addition of Loratadine Versus Placebo in Participants With Seasonal Allergic Rhinitis (C94-145)
Status: COMPLETED
Conditions: Rhinitis, Allergic
Interventions: DRUG: Mometasone furoate nasal spray (MFNS)|DRUG: Loratadine|DRUG: Placebo nasal spray|DRUG: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Psychosocial Treatment for Improving Chances of Survival in Women With Breast Cancer
Status: COMPLETED
Conditions: Stage IIIB, IV, Recurrent, and Metastatic Breast Cancer
Interventions: BEHAVIORAL: Supportive-Expressive Group Therapy plus education|BEHAVIORAL: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide and Dexamethasone With or Without Bortezomib in Treating Patients With Previously Untreated Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: DS Stage I Multiple Myeloma|DS Stage II Multiple Myeloma|DS Stage III Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: Dexamethasone|OTHER: Laboratory Biomarker Analysis|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Blinded Study Comparing the Safety and Efficacy of a Fully Human Anti-IL8 Monoclonal Antibody (ABX-IL8) to Placebo in Patients With Chronic Bronchitis and COPD
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|Bronchitis, Chronic
Interventions: DRUG: ABX-IL8
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Pre-Approval Access Program (PAAP) for Pralsetinib (BLU-667) in Patients With Unresectable or Metastatic NSCLC or MTC
Status: APPROVED_FOR_MARKETING
Conditions: Non-Small Cell Lung Cancer|Medullary Thyroid Cancer
Interventions: DRUG: pralsetinib (BLU-667)
Study Type: EXPANDED_ACCESS
Clinical trial: MANAGe-DM: Novel Nurse Case Management to Improve Diabetes Outcomes in Black Men Recently Released From Incarceration
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: MANAGe-DM - novel nurse case management|BEHAVIORAL: Monthly Educational Mailing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mitoxantrone Hydrochloride Liposome Injection in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
Status: RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Mitoxantrone Hydrochloride Liposome Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Community Self-help Using Thought Field Therapy in a Traumatised Population in Uganda: a Randomised Trial
Status: COMPLETED
Conditions: Post-traumatic Stress Disorder
Interventions: BEHAVIORAL: Thought Field Therapy.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LISA Catheter With Marked vs. Unmarked Tip in Extremely Low Birth Weight Infants With RDS
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Newborn
Interventions: DEVICE: Surfactant administration with less invasive surfactant administration (LISA) marked tip catheter|DEVICE: Surfactant administration with less invasive surfactant administration (LISA) unmarked tip catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outpatient Transcervical Balloon For Induction of Labor
Status: RECRUITING
Conditions: Induced Vaginal Delivery|Induced; Birth
Interventions: PROCEDURE: Outpatient transcervical foley balloon|PROCEDURE: Inpatient Vaginal Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Integrative Therapies for Symptom Management in Adults With Acute Leukemia
Status: SUSPENDED
Conditions: Acute Myeloid Leukemia
Interventions: BEHAVIORAL: Integrative Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Decitabine Plus R-CHOP in Diffuse Large B-cell Lymphoma
Status: UNKNOWN
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone|DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare How Well Gadoquatrane Works and Its Safety With an Already Available Contrast Agent for MRI in People With Any Known or Suspected Problems of the Body (Except Brain or Spinal Cord-related Problems)
Status: COMPLETED
Conditions: Contrast Enhancement in Magnetic Resonance Imaging|Non-central Nervous System Pathology
Interventions: DRUG: Gadoquatrane (BAY1747846)|DRUG: Gadobutrol|DRUG: Gadoterate meglumine|DRUG: Gadoteridol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Reducing Up-set Stomach and Vomiting After Surgery Using Essential Oils
Status: COMPLETED
Conditions: Nausea
Interventions: OTHER: Peppermint oil|OTHER: Ginger oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of P-glycoprotein Inhibition on Lenalidomide Pharmacokinetics in Healthy Males
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lenalidomide|DRUG: Quinidine|DRUG: Temsirolimus|DRUG: Diphenhydramine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: HP011-101, HP828-101, and Standard Care for Pressure Ulcers
Status: WITHDRAWN
Conditions: Pressure Ulcers
Interventions: DRUG: HP011-101|DEVICE: HP-828-101|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sharing and Talking About my Preferences
Status: UNKNOWN
Conditions: Chronic Disease
Interventions: BEHAVIORAL: Computer-Tailored Intervention|BEHAVIORAL: Motivational Interviewing|BEHAVIORAL: Motivational Enhancement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Tislelizumab in Combination With SOX for the Treatment of Gastric Cancer With Liver Metastases
Status: RECRUITING
Conditions: Liver Metastases
Interventions: DRUG: Tislelizumab in Combination with Oxaliplatin and Tegafur
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study Between Two Oral Formulations of Famotidine Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Bioavailability
Interventions: DRUG: Famotidine Tablets, 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Innovative Public-private Partnership to Target Subsidized Antimalarials in the Retail Sector (Aim 2)
Status: COMPLETED
Conditions: Fever|Malaria
Interventions: BEHAVIORAL: Malaria RDT & conditional voucher for ACT from retail sector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Epzicom and Truvada for the Initial Once Daily HIV Treatment
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: lamivudine, abacavir , ritonavir, atazanavir|DRUG: emtricitabine, tenofovir, ritonavir, atazanavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Occupational Heat Stress on Workers' Productivity
Status: COMPLETED
Conditions: Risk of Heat Stress
Interventions: OTHER: Work/ rest scenario|OTHER: Hydration scenario|OTHER: Clothing scenario|OTHER: "E-carts" scenario|OTHER: Business as usual scenario|OTHER: Sham evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Biomarkers for Apatinib and Bevacizumab in Second-line Therapy for Colorectal Cancer(BABST-C)
Status: SUSPENDED
Conditions: Colorectal Neoplasms
Interventions: DRUG: Apatinib Mesylate Tablets|DRUG: Bevacizumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of a Chronic Care Model Supported by Self Monitoring of Blood Glucose With BGStar Over Usual Care in Improving Glycemic Control in Patients With Type 2 Diabetes Not Treated With Insulin
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: BGStar|DEVICE: glucose meter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home Based Daratumumab Administration for Patients With Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Plasma Cell Myeloma
Interventions: DRUG: Daratumumab and Hyaluronidase-fihj|OTHER: Questionnaire Administration|OTHER: Quality-of-Life Assessment|OTHER: Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetuximab, Carboplatin, and Paclitaxel Followed by Radiation Therapy, With or Without Cisplatin, in Treating Patients With Metastatic Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: Cetuximab|DRUG: Carboplatin|DRUG: Paclitaxel|PROCEDURE: Conventional Surgery|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of hA20 (Humanized Anti-CD20) in Patients With CD20+ Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: hA20-humanized anti-CD20 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial of Coaching Into Care With VA-CRAFT to Promote Veteran Engagement in PTSD Care
Status: RECRUITING
Conditions: Stress Disorders, Post-traumatic
Interventions: BEHAVIORAL: CIC+VA-CRAFT|BEHAVIORAL: CIC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effectiveness and Efficacy of the PowerSleep Device
Status: COMPLETED
Conditions: Sleep Deprivation|Insufficient Sleep Syndrome|Healthy
Interventions: DEVICE: PowerSleep Stim|DEVICE: PowerSleep Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Talazoparib Plus Enzalutamide After Progression to Abiraterone in Metastatic Prostate Cancer: (TEAM PC)
Status: RECRUITING
Conditions: Metastatic Prostate Cancer
Interventions: DRUG: Enzalutamide capsule|DRUG: Enzalutamide capsule and Talazoparib capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SPI-62 as a Treatment for Adrenocorticotropic Hormone-dependent Cushing's Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Cushing's Syndrome I|Cushing Disease Due to Increased ACTH Secretion|Cortisol Excess|Cortisol; Hypersecretion|Cortisol Overproduction|Ectopic ACTH Secretion
Interventions: DRUG: SPI-62|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise Dose-Response on Features of the Metabolic Syndrome
Status: COMPLETED
Conditions: Insulin Resistance|Metabolic Syndrome|Obesity
Interventions: BEHAVIORAL: Low-intensity treadmill exercise|BEHAVIORAL: Moderate-intensity treadmill exercise|BEHAVIORAL: Non-aerobic stretching exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conservative Versus Surgical Treatment of Native Vertebral Osteomyelitis
Status: UNKNOWN
Conditions: Vertebral Osteomyelitis|Spondylodiscitis|Surgical Procedure, Unspecified
Interventions: PROCEDURE: Surgical treatment|OTHER: Antimicrobial treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HIIT for Inflammatory Rheumatic Disease: Man vs Machine
Status: COMPLETED
Conditions: Inflammatory Rheumatism
Interventions: BEHAVIORAL: Effective endurance 4x4 training - Supervised|DEVICE: Effective endurance 4x4 training - APP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Additive Renoprotective Effects of Oral Calcitriol in IgA Nephropathy Patients Taking Renin-Angiotensin System Blockers
Status: COMPLETED
Conditions: IgA Nephropathy
Interventions: DRUG: Calcitriol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Citrulline Supplementation Combined With Exercise: Effect on Muscle Function in Elderly People (CITEX Study)
Status: COMPLETED
Conditions: Sarcopenia|Obesity
Interventions: DIETARY_SUPPLEMENT: Citrulline|OTHER: Placebo|BEHAVIORAL: Exercise|OTHER: without exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Plasma-Derived Human Butyrylcholinesterase Administered Intramuscularly
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Human butyrylcholinesterase (HuBChE) derived from human plasma|DRUG: Placebo: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sapanisertib and Serabelisib (PIKTOR) With Paclitaxel, Serabelisib With Paclitaxel, and Paclitaxel Alone in Patients With Advanced/Recurrent Endometrial Cancer
Status: NOT_YET_RECRUITING
Conditions: Endometrial Cancer
Interventions: DRUG: Sapanisertib|DRUG: Serabelisib|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Press Fit Condylar (P.F.C.) Sigma Metal-backed Versus All-poly
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: PFC Sigma knee with all-poly tibial component|DEVICE: PFC Sigma knee with metal backed tibia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Supplementation With PUFAs and Antioxidants for Contact Lens Discomfort
Status: TERMINATED
Conditions: Dry Eye|Contact Lens Complication
Interventions: DRUG: HydroEye®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing of a System for Remote Ischemic Conditioning in Cerebral Small Vessel Disease and Pre-hospital Stroke Care
Status: NOT_YET_RECRUITING
Conditions: Cerebral Small Vessel Diseases|Cerebral Small Vessel Ischemic Disease|Ischemic Stroke|Vascular Cognitive Impairment|Stroke, Acute
Interventions: DEVICE: Remote ischemic conditioning (RIC) progammable device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Periarticular Multimodal Drug Injections in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: ropivacaine|DRUG: morphine sulfate|DRUG: ketorolac|DRUG: epinephrine|DRUG: cefuroxime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Laser Iridotomy Versus Phacoemulsification in Acute Angle Closure
Status: COMPLETED
Conditions: Angle Closure Glaucoma
Interventions: PROCEDURE: Laser Preipheral Iridotomy and phacoemulsification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lid Wipes Versus Baby Shampoo in Patients With Seborrehic Blepharitis
Status: COMPLETED
Conditions: Seborrheic Blepharitis
Interventions: DRUG: Lid wipes containing terpinen-4-ol and sodium hyaluronate|DRUG: Baby shampoo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Letrozole Combined With Metronomic Oral Cyclophosphamide in Elderly Metastasis Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Neoplasms|Neoplasm Metastasis
Interventions: DRUG: Cyclophosphamide 50mg|DRUG: Letrozole 2.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Function Substudy for Subjects Enrolled in Studies MKC-TI-161, MKC-TI-162 or MKC-TI-166
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus
Interventions: DRUG: Comparator administered in parent trial|DRUG: Technosphere Insulin Inhalation Powder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioavailability of BI 1356 and Glyburide in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1356|DRUG: Glyburide|DRUG: BI 1356 + Glyburide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ceritinib Rare Indications Study in ALK+ Tumors
Status: TERMINATED
Conditions: Tumors With Aberrations in ALK|Anaplastic Large Cell Lymphoma|Inflammatory Myofibroblastic Tumor|Glioblastoma
Interventions: DRUG: Ceritinib (LDK378)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HLA-Identical Sibling Renal Transplant Tolerance
Status: ACTIVE_NOT_RECRUITING
Conditions: Immunosuppression|Kidney Transplantation|Graft Rejection
Interventions: BIOLOGICAL: Infusion of Donor Hematopoietic Stem Cells and Campath-1H
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Vibration Training on Functional Recovery and Mood State Among Patients With Acute Stroke
Status: RECRUITING
Conditions: Vibration; Exposure|Rehabilitation
Interventions: DEVICE: Vibration training|BEHAVIORAL: ergometer exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neurofeedback for Treatment Resistant Depression
Status: RECRUITING
Conditions: Treatment Resistant Depression
Interventions: BEHAVIORAL: Amygdala Neurofeedback|BEHAVIORAL: Parietal Neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Isatuximab Added to Standard CyBorD Induction and Lenalidomide Maintenance Treatments in ND-TEMM
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: OTHER: Isatuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Renal Impairment on the Pharmacokinetics and Safety of VIR-2218
Status: RECRUITING
Conditions: Renal Impairment
Interventions: DRUG: VIR-2218
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Perioperative and Postoperative Music Reduces Pain Perception After Anterior Cruciate Ligament Reconstruction
Status: ACTIVE_NOT_RECRUITING
Conditions: Anterior Cruciate Ligament Tear
Interventions: DEVICE: slow beat mesic listening by headphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Basic Experimental Study of Hippocampal Memory Functions
Status: ENROLLING_BY_INVITATION
Conditions: Memory
Interventions: BEHAVIORAL: Different cognitive and memory demands during the memory experiment|OTHER: Different electrical stimulation parameters during cognitive and memory demands
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Analysis of Hemostatic Agents Compared to Physiologic Hemostasis
Status: COMPLETED
Conditions: Rhino Sinusitis
Interventions: DEVICE: Arista|DEVICE: Nexfoam|DEVICE: Nasopore
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D for Muscle Metabolic Function in Cancer Cachexia
Status: COMPLETED
Conditions: Cancer Cachexia|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acalabrutinib and Durvalumab in Primary and Secondary Central Nervous System Lymphoma
Status: RECRUITING
Conditions: Primary Central Nervous System Lymphoma
Interventions: DRUG: Durvalumab|DRUG: Acalabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Non-pharmaceutical Treatments for Evaporative Dry Eye
Status: NOT_YET_RECRUITING
Conditions: Dry Eye
Interventions: DEVICE: IPL|DEVICE: Heated eye mask|DEVICE: LipiFlow®|DEVICE: EyePeace®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trials of Two Helichrysum Infusions in Adults
Status: COMPLETED
Conditions: Hypertension|Hyperlipidemias|Inflammation|Hyperglycemia|Hypercholesterolemia|Microbial Colonization|Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: Helichrysum italicum infusion|DIETARY_SUPPLEMENT: Helichrysum arenarium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Cellular Matrix Device for the Treatment of Mild to Moderate Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Cellular Matrix / A-CP HA Kit|DEVICE: Synvisc-One
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM)
Status: UNKNOWN
Conditions: Preterm Premature Rupture of Membranes
Interventions: DRUG: indomethacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Continuous Irrigation Combined With Transgastric Necrosectomy usingLAMS in Treatment of SAP
Status: COMPLETED
Conditions: Severe Acute Pancreatitis|Pancreatic Necrosis
Interventions: PROCEDURE: Percutaneous Continuous Irrigation assisted Vacuum Drainage Combined With Transgastric Necrosectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Abnormal Adipose Tissue Accumulation in Human Immunodeficiency Virus (HIV) Patients
Status: COMPLETED
Conditions: HIV Infections|Lipodystrophy
Interventions: DRUG: Placebo|DRUG: Serostim® 4 mg|DRUG: Serostim® 2 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of KI1001 in ≥ 55 Years Old Insomnia Patients
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders
Interventions: DRUG: KI1001|DRUG: Placebo KI1001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Two Part Study to Assess Safety, PK, PD, and Food Effect of Oral HTL0016878
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HTL0016878|DRUG: Placebo - Concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Study the Safety and Efficacy of Bone Marrow Derived Autologous Cell for the Treatment of Stroke.
Status: UNKNOWN
Conditions: Stroke,
Interventions: OTHER: Intra thecal transplantation of Autologous Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ph IIA Study (SOC +/- NS5B)
Status: COMPLETED
Conditions: Hepatitis C Virus
Interventions: DRUG: BMS-791325|DRUG: BMS-791325|DRUG: Placebo|DRUG: Peg-interferon alfa-2a|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Post Ablation Medroxyprogesterone Acetate on Endometrial Amenorrhea Rates
Status: TERMINATED
Conditions: Menorrhagia
Interventions: DRUG: MPA|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the STARFlex® Septal Closure System in Patients With a Stroke or TIA Due to the Possible Passage of a Clot of Unknown Origin Through a Patent Foramen Ovale (PFO)
Status: UNKNOWN
Conditions: Patent Foramen Ovale|Stroke|Ischemic Attack, Transient
Interventions: DEVICE: STARFlex septal closure system|DRUG: Best medical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using a Smartphone App to Aid in Functional Mobility Return Following Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Total Knee Arthroplasty
Interventions: DEVICE: Smartphone App|COMBINATION_PRODUCT: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Triphala Supplementation and High-intensity Interval Exercise and Immune System Function and Oxidative Stress
Status: COMPLETED
Conditions: Triphala Capsule Supplementation|High-intensity Interval Training
Interventions: OTHER: Triphala capsule supplementation and high-intensity interval training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Latanoprost/Timolol for Primary Open Angle Glaucoma
Status: UNKNOWN
Conditions: Primary Open Angle Glaucoma
Interventions: DRUG: Latanoprost/Timolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of TRC105 in the Treatment of Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Carcinoma
Status: COMPLETED
Conditions: Recurrent Ovarian Cancer|Fallopian Tube Carcinoma|Primary Peritoneal Carcinoma
Interventions: BIOLOGICAL: Carotuximab (TRC105)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ahmed Glaucoma Valve and Single-Plate Molteno Implants in Treatment of Refractory Glaucoma
Status: COMPLETED
Conditions: Refractory Glaucoma
Interventions: DEVICE: Ahmed valve implant|DEVICE: Molteno single-plate implant (MSPI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: INTRACEPT: Prospective, Randomized, Multi-center Study Intraosseous Basivertebral Nerve Ablation for Treatment of CLBP
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: DEVICE: Intracept System|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Muscle Invasive Bladder Cancer
Interventions: DRUG: AZD4547|DRUG: MEDI4736|DRUG: Olaparib|DRUG: AZD1775|DRUG: Vistusertib|DRUG: AZD9150|DRUG: Selumetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of CC-292 and Lenalidomide in Subjects With Chronic Lymphocytic Leukemia/ Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Leukemia Lymphocytic Chronic B-Cell
Interventions: DRUG: CC-292|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Implant Design Improve Postoperative Flexion?
Status: COMPLETED
Conditions: Non-inflammatory Arthritis
Interventions: DEVICE: Total knee replacement using the PFC Sigma RPF knee implant.|DEVICE: Total knee replacement using the PFC Sigma RP knee implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Food Supplement Composed by BIOintestil ® (Bionocol®) on Microbiota and Inflammatory Profile in Irritable Bowel Syndrome Patients
Status: TERMINATED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: BIOintestil|DIETARY_SUPPLEMENT: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Progression Free Survival in Cancer Patients With Advanced Colorectal Carcinoma With AMT2003
Status: TERMINATED
Conditions: Colorectal Carcinoma
Interventions: DRUG: AMT2003
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BAttLe Against COVID-19 Using MesenchYmal Stromal Cells
Status: SUSPENDED
Conditions: COVID|Respiratory Distress Syndrome
Interventions: DRUG: Allogeneic and expanded adipose tissue-derived mesenchymal stromal cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dietary Nitrate on the Oral Microbiome
Status: COMPLETED
Conditions: Cardiovascular Health|Identify Oral Bacteria Responsible for Nitrate Reduction
Interventions: DIETARY_SUPPLEMENT: Nitrate-rich beetroot juice|DIETARY_SUPPLEMENT: Nitrate-depleted beetroot juice|OTHER: Mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Radiation/Cetuximab Plus EGFR Antisense DNA for Head and Neck Squamous Cell Carcinoma
Status: TERMINATED
Conditions: Carcinoma, Squamous Cell of Head and Neck|Squamous Cell Carcinoma of the Head and Neck|Squamous Cell Carcinoma, Head And Neck
Interventions: BIOLOGICAL: EGFR Antisense DNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Zotarolimus-eluting Stent Overexpansion With OCT
Status: RECRUITING
Conditions: Coronary Artery Disease|Optical Coherence Tomography|Stent
Interventions: DEVICE: Optical coherence tomography-guided percutaneous coronary intervention|DEVICE: Optical coherence tomography-guided Onyx family stent expansion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Immunomodulation Study of Simultaneous Human Papillomavirus/ Hepatitis B (HPV/HBV) Vaccination
Status: TERMINATED
Conditions: Human Papillomavirus Infection
Interventions: BIOLOGICAL: Cervarix|BIOLOGICAL: Engerix-B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Rhodiola Crenulata as an Adjunctive Therapy in COPD
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Rhodiola placebo capsules|DRUG: Rhodiola Crenulata
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: PRP Treatment|BIOLOGICAL: HA Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of the Safety, Transmissibility, and Phenotypic and Genotypic Stability of Influenza Virus Vaccine,(CAIV-T), in Children Who Attend Day Care. (Final Report Version 2.0)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: CAIV-T
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Trial of Plitidepsin (Aplidin®) in Combination With Bortezomib and Dexamethasone in Multiple Myeloma Patients Double Refractory to Bortezomib and Lenalidomide
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: plitidepsin|DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics of ELX-02 in Healthy Adult Volunteers
Status: TERMINATED
Conditions: Genetic Diseases|Nonsense Mutations
Interventions: DRUG: ELX-02|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Worm Study: Modifier Genes in Sudden Cardiac Death
Status: RECRUITING
Conditions: Brugada Syndrome|Long QT Syndrome 3
Interventions: PROCEDURE: Dermal biopsy|BEHAVIORAL: Gastro-intestinal questionnaire|GENETIC: Whole-exome sequencing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: OnabotulinumtoxinA as Treatment for Major Depressive Disorder in Adult Females
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: BIOLOGICAL: onabotulinumtoxinA|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Latin Dance on Middle School Girls' Social Physique Anxiety and Physical Self-esteem
Status: UNKNOWN
Conditions: Mental Health Issue|Physical Illness
Interventions: BEHAVIORAL: Latin dance: Rumba|BEHAVIORAL: Latin dance: Cha Cha Cha
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: TMTP1-ICG Mapping in Colposcopy-directed Biopsy
Status: UNKNOWN
Conditions: Cervical Intraepithelial Neoplasia
Interventions: DRUG: TMTP1|DRUG: ICG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Donor T Cells, Low-Dose Aldesleukin, and Low-Dose GM-CSF After Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
Status: WITHDRAWN
Conditions: Lymphoma
Interventions: BIOLOGICAL: anti-CD3 x anti-CD20 bispecific antibody-armed activated T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: APRIL CAR-T Cell Therapy for Patients With BCMA/TACI Positive Relapsed and/or Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma in Relapse|Multiple Myeloma, Refractory
Interventions: DRUG: APRIL CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Pulmonary Arterial Hypertension in Patients With Systemic Sclerosis
Status: WITHDRAWN
Conditions: Systemic Sclerosis|Pulmonary Hypertension
Interventions: RADIATION: Ultrasound radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC