pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Focal Therapy for Prostate Cancer Using HIFU
Status: RECRUITING
Conditions: Male Erectile Disorder|Prostate Cancer|Therapy-related Toxicity|Urinary Incontinence
Interventions: OTHER: questionnaire administration|PROCEDURE: assessment of therapy complications|PROCEDURE: high-intensity focused ultrasound ablation|PROCEDURE: multiparametric magnetic resonance imaging|PROCEDURE: quality-of-life assessment|PROCEDURE: transperineal prostate biopsy|PROCEDURE: transrectal prostate biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Boned-Apatite Cement at the Time of Extraction for Ridge Preservation at These Sites
Status: COMPLETED
Conditions: Alveolar Bone Loss
Interventions: DEVICE: Bond Apatite synthetic bone substitute|DEVICE: BioOss bovine bone substitute
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study to Evaluate the Efficacy and Safety of Glassia® in Type-1 Diabetes
Status: COMPLETED
Conditions: New Onset Type-1 Diabetes
Interventions: BIOLOGICAL: Alpha-1 Antitrypsin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Imaging Study Of Rosiglitazone Efficacy And Safety In Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Rosiglitazone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-CD19 Chimeric Antigen Receptor Modified T-cell (CAR-T) Therapy for Treatment of B-cell Hematological Malignancies
Status: RECRUITING
Conditions: Lymphoma, Nonhodgkin|Leukemia, Lymphocytic
Interventions: DRUG: CUCART19
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label, Multi-arm, Non-comparative Safety and Tolerability Study of Canakinumab (ACZ885) in Patients With Active Systemic Juvenile Idiopathic Arthritis (SJIA)
Status: WITHDRAWN
Conditions: Systemic Juvenile Idiopathic Arthritis
Interventions: DRUG: ACZ885|DRUG: Canakinumab|DRUG: Canakinumab|DRUG: Canakinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: THE EFFECT OF MOTHER'S VOICE AND LULLABY ON PRETERM INFANTS' PHYSIOLOGICAL PARAMETERS, STRESS AND SLEEPING- WAKING STATE
Status: COMPLETED
Conditions: Preterm Birth
Interventions: BEHAVIORAL: Music Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Safety, Tolerability and Clinical Outcomes of Egaten in Fascioliasis Patients (6 Years of Age or Older).
Status: RECRUITING
Conditions: Fascioliasis
Interventions: DRUG: Egaten (Triclabendazole) 250 mg tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety of Tocilizumab in Addition to Standard of Care Premedication Given Before Obinutuzumab + Chlorambucil in Participants With Untreated B-Cell Chronic Lymphocytic Leukemia (B-CLL) and Comorbidities
Status: TERMINATED
Conditions: B-Cell Chronic Lymphocytic Leukemia
Interventions: DRUG: Chlorambucil|DRUG: Obinutuzumab|DRUG: Placebo|OTHER: Standard Premedication|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of Blood Biomarkers for Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease|Mild Cognitive Impairment|Dementia|Tauopathies
Interventions: DIAGNOSTIC_TEST: Measurement of amyloid and pTau blood biomarkers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: SGA-induced Metabolic Syndrome in Bipolar Youth
Status: COMPLETED
Conditions: Bipolar Youth Treated With Second-generation Antipsychotics
Interventions: DRUG: Omega|DRUG: Placebo|DRUG: Quetiapine fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of KP-100LI in Subjects With Vocal Fold Scar
Status: RECRUITING
Conditions: Vocal Fold Scar
Interventions: DRUG: KP-100LI|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Very Low Protein Diet or Dialysis in Uremic Elderly?
Status: COMPLETED
Conditions: Uremia|Elderly (Aged >70)|Dialysis|Low Protein Diet|Survival
Interventions: DRUG: mixture of amino and keto acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Malnutrition on the Healing of Foot Lesions in Diabetic Patients
Status: COMPLETED
Conditions: Patients With Type 1 or 2 Diabetes|Lesion Situated on a Toe or on the Plantar or Dorsal Side of the Foot
Interventions: OTHER: biological examination at consultations at 3 and 6 months
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Pain of Two Different Methods in Uterine Artery Embolization
Status: COMPLETED
Conditions: Leiomyoma
Interventions: DEVICE: Non-spherical polyvinyl alcohol particle or Tris-acryl gelatin microsphere
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Comparative Study of JNS013 in Participants With Post-Tooth-Extraction Pain
Status: COMPLETED
Conditions: Pain|Postoperative Pain
Interventions: DRUG: Tramadol Hydrochloride|DRUG: Acetaminophen|DRUG: Placebo|DRUG: Tramadol plus Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Vosaroxin With Azacitidine in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome With Excess Blasts-2
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome With Excess Blasts-2 (MDS-EB-2)
Interventions: DRUG: Vosaroxin|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Learning Curve in Low Anterior Resection for Rectal Resection With the Two Surgical Robots
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DEVICE: Micro Hand S robot and da Vinci robot|DEVICE: da Vinci robot
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Duration of Antimicrobial Susceptibility Test (AST) Guided Rescue Therapy for Helicobacter Pylori Infection
Status: UNKNOWN
Conditions: Therapeutic Duration|Helicobacter Pylori|Antimicrobial Susceptibility Test|Eradication
Interventions: OTHER: 7-day triple regimen guided by AST|OTHER: 10-day triple regimen guided by AST|OTHER: 14-day triple regimen guided by AST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcome of Implant-supported Overdentures
Status: UNKNOWN
Conditions: Alveolar Bone Loss|Bone Resorption|Dental Implants|Edentulous Maxilla|Edentulous Patient
Interventions: DEVICE: dental implants and stud attachments
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of AAD and IPV to Treat Hospitalized Infants (<2years) With Acute Viral Bronchiolitis.
Status: COMPLETED
Conditions: Bronchiolitis
Interventions: OTHER: inhalation 4ml hypertonic saline 3% 3x/day|DEVICE: Intrapulmonary Percussive Ventilation|PROCEDURE: Assisted Autogenic Drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Bevacizumab for Choridal Neovascularization Secondary to Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Age Related Macular Degeneration
Interventions: DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Treatments for COVID-19 in Hospitalized Adults
Status: COMPLETED
Conditions: Corona Virus Infection
Interventions: DRUG: Remdesivir|DRUG: Lopinavir/ritonavir|DRUG: Interferon Beta-1A|DRUG: Hydroxychloroquine|OTHER: Standard of care|DRUG: AZD7442|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Side Access Mucosal Releasing Incision (SAMRI) and Sulcular Tunnel Access to Treat Gingival Recession.
Status: ACTIVE_NOT_RECRUITING
Conditions: Gingival Recession|Lack of Keratinized Gingiva
Interventions: PROCEDURE: SAMRI|PROCEDURE: STA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Esflurbiprofen Hydrogel Patch in the Treatment of Local Acute Pain
Status: COMPLETED
Conditions: Soft Tissue Injuries|Contusions|Strains|Sprains|Bruises
Interventions: DRUG: Esflurbiprofen Hydrogel Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-response Study of Carduus Marianus in Centesimal Scale for Dyslipidemia in Climacteric Overweighed or Obese Women.
Status: TERMINATED
Conditions: Dyslipidemia|Menopause|Obesity
Interventions: DRUG: Carduus marianus 6cH|DRUG: Carduus marianus 12cH|DRUG: Carduus marianus 30cH|DRUG: Placebo|BEHAVIORAL: Exercise|OTHER: Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of a Health and Mental Health Promotion Intervention Among Jordanians and Syrians.
Status: COMPLETED
Conditions: Mental Stress|Hypertension|Diabetes
Interventions: BEHAVIORAL: Healthy community clinic NCD+MH|BEHAVIORAL: Healthy community clinic NCD
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial of Low-Dose Xenon For The Treatment Of Obsessive-Compulsive Disorder
Status: WITHDRAWN
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: Xenon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of MD-1100 Acetate Administered for 14 Days to Patients Meeting Criteria for Chronic Constipation
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: MD-1100 Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Oasis Donor Site Wounds Post-Market Study
Status: RECRUITING
Conditions: Surgical Wound|Wound|Wounds and Injuries|Wound Heal
Interventions: DEVICE: Oasis ECM|OTHER: standard wound care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy and sAfety of Intravenous Infusion of Nicorandil During Primary Percutaneous Coronary Intervention
Status: RECRUITING
Conditions: ST Elevation Myocardial Infarction|Percutaneous Coronary Intervention
Interventions: DRUG: Nicorandil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chinese Multiple Dose Escalation (MDE) High Dose Study
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: Experimental: Cotadutide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Pharmacokinetics of Oral Nicotine Pouches and Lozenges in Healthy Adults
Status: COMPLETED
Conditions: Tobacco Use|Tobacco Smoking|Cigarette Smoking
Interventions: OTHER: Product A|OTHER: Product B|OTHER: Product C|OTHER: Product D|OTHER: Product E|OTHER: Product F
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Sirolimus-based Immunosuppression Treatment Regimen for Liver Transplantation
Status: UNKNOWN
Conditions: Liver Transplantation
Interventions: DRUG: Tacrolimus|DRUG: Tacrolimus (Tacrolimus elimination)|DRUG: Sirolimus|DRUG: MMF and/or steroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Ecoguided Percutaneous Neuromodulation of the Multipurpose Musculature of L-3 in Non-specific Chronic Lumbar Pain.
Status: RECRUITING
Conditions: Low Back Pain
Interventions: OTHER: Ultrasound- guided Percutaneous Neuromulation|OTHER: TENS Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Avocado Fruit on Postprandial Markers of the Glycemic Response, Satiety/Appetite and Cardiometabolic Risk
Status: COMPLETED
Conditions: Glycemic Response
Interventions: DIETARY_SUPPLEMENT: Test meal 1|DIETARY_SUPPLEMENT: Test meal 2|DIETARY_SUPPLEMENT: Control Meal (CM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: TMC435350-TiDP16-C106: A Phase I Trial to Compare the Bioavailability and Plasma Pharmacokinetics After a Single Oral Dose of TMC435350 of 2 Different Solid Formulations Relative to a Powder Blend Capsule
Status: COMPLETED
Conditions: Hepatitis C|HCV
Interventions: DRUG: TMC435350
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD19- and CD22-directed CAR-T Cell Therapy in Patients With Acute Lymphoblastic Leukemia
Status: WITHDRAWN
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: IMJ995 single agent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Disordered Breathing, Obesity and Pregnancy Study (SOAP)
Status: COMPLETED
Conditions: Obese|Pregnancy|Sleep Disordered Breathing
Interventions: DEVICE: CPAP|DEVICE: sham-CPAP|OTHER: Sleep hygiene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sodium Oxybate in Patients With Episodic and Chronic Cluster Headache
Status: UNKNOWN
Conditions: Cluster Headache
Interventions: DRUG: Sodium Oxybate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerance, Efficacy and Pharmacokinetics of JS005 Multiple Dosing
Status: COMPLETED
Conditions: Moderate to Severe Psoriasis
Interventions: BIOLOGICAL: JS005 (recombinant humanized monoclonal antibody against IL-17A)|BIOLOGICAL: JS005 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chronic Presence of Epstein Barr Virus in Sulcular and Junctional Epithelial Tissue From Gingiva is Associated With Severe Periodontitis
Status: COMPLETED
Conditions: Parodontitis Aggressive|Parodontitis Chronic
Interventions: PROCEDURE: Biopsy|PROCEDURE: biopsy|PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of VIC Regimen in BRAF Mutant Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer Metastatic
Interventions: DRUG: Cetuximab|DRUG: Irinotecan|DRUG: Vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physician-Modified Fenestrated and Branched Aortic Endografting for TAAA
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Aneurysm, Thoracoabdominal
Interventions: DEVICE: Physician-modified aortic endograft
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hormone Estradiol Replacement Therapy Additional Herbals
Status: COMPLETED
Conditions: Menopause
Interventions: DRUG: ESTROGEN HERBALS 21|DRUG: ESTROGEN HERBALS 28
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Randomized Placebo-Controlled Trial of Budesonide Multi-Matrix System (MMX®) 9 Milligrams (mg) in Participants With Ulcerative Colitis Currently on a 5-Aminosalicylic Acid (5-ASA)
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Budesonide MMX®|DRUG: Placebo|DRUG: 5-ASA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Bradykinin Receptor Antagonism on ACE Inhibitor-associated Angioedema
Status: TERMINATED
Conditions: ACE Inhibitor-associated Angioedema
Interventions: DRUG: icatibant|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft
Status: COMPLETED
Conditions: Unstable Angina|Coronary Artery Bypass Graft|Dexmedetomidine|Lidocaine|Myocardial Injury|Arrhythmia|Blood Electrolyte Balance
Interventions: DRUG: Lidocaine infusion|DRUG: Dexmedetomidine infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Study to Evaluate sUA-Lowering Activity, Safety & PK Interaction of Oral BCX4208 & Allopurinol Admin. in Subjects w/Gout
Status: COMPLETED
Conditions: Gout
Interventions: DRUG: Placebo|DRUG: Allopurinol|DRUG: Allopurinol|DRUG: Allopurinol|DRUG: BCX4208|DRUG: Allopurinol|DRUG: Allopurinol|DRUG: Allopurinol|DRUG: BCX4208|DRUG: Allopurinol|DRUG: Allopurinol|DRUG: Allopurinol|DRUG: BCX4208|DRUG: Allopurinol|DRUG: Allopurinol|DRUG: Allopurinol|DRUG: BCX4208
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Evaluation of Two Year Imatinib Treatment in Adjuvant Gastrointestinal Stromal Tumor (GIST)
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumors
Interventions: DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of the Usability and Efficacy of a New Pediatric CPAP Mask
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Respiratory Insufficiency
Interventions: DEVICE: Prototype mask (known as Pixi)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: aICP in Glaucoma and Papilledema
Status: UNKNOWN
Conditions: Open-angle Glaucoma|Papilledema
Interventions: DEVICE: Non-invasive ICP measurement (Vittamed 305)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Reduced Dexamethasone Pre-Medication Dose in Elderly Patients Receiving Weekly Docetaxel
Status: TERMINATED
Conditions: Breast Cancer|Lung Cancer
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Perioperative Chemotherapy Plus PD-1 Antibody in the Locally Advanced Gastric Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Cancer|Locally Advanced Solid Tumor
Interventions: DRUG: JS001|DRUG: Oxaliplatin|DRUG: S1|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tenofovir Alafenamide (TAF) Versus Tenofovir Disoproxil Fumarate (TDF)-Containing Regimens in Participants With Chronic Hepatitis B Virus (HBV) Infection and Stage 2 or Greater Chronic Kidney Disease Who Have Received a Liver Transplant
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: TAF|DRUG: TDF|DRUG: Other approved antivirals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of the Performance of the enVista® Aspire™ (EA) Lens
Status: RECRUITING
Conditions: Cataract
Interventions: DEVICE: enVista® Aspire™|DEVICE: An IOL with a slightly extended depth of focus|DEVICE: MX60E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Conversion to Sirolimus vs. Continued Use of Calcineurin Inhibitors in Kidney Transplant Recipients
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: Sirolimus|DRUG: tacrolimus|DRUG: Cyclosporine A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3484356 in Participants With Advanced or Metastatic Breast Cancer or Endometrial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Advanced Breast Cancer|Metastatic Breast Cancer|Endometrial Cancer
Interventions: DRUG: LY3484356|DRUG: Abemaciclib|DRUG: Everolimus|DRUG: Alpelisib|DRUG: Trastuzumab|DRUG: Aromatase Inhibitor (AI)|DRUG: Pertuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Pharmacokinetics, Safety, and Tolerability Ildong COL-144 Tablet in Korean Healthy Volunteers
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: COL-144 50mg|DRUG: COL-144 100mg|DRUG: COL-144 200mg|DRUG: COL-144 400mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Boronophenylalanine-Fructose Complex (BPA-F) and/or Sodium Borocaptate (BSH) Followed By Surgery in Treating Patients With Thyroid Cancer, Head and Neck Cancer, or Liver Metastases
Status: COMPLETED
Conditions: Colorectal Cancer|Head and Neck Cancer|Metastatic Cancer
Interventions: DRUG: boronophenylalanine-fructose complex|DRUG: sodium borocaptate|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) Trial
Status: COMPLETED
Conditions: Coronary Disease|Arteriosclerosis|Diabetes Mellitus, Type 2
Interventions: DRUG: Aspirin|DRUG: No aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Stereotactic Body Radiotherapy (SBRT) Plus Immunotherapy for Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Nivolumab|DRUG: Cabiralizumab|DRUG: Urelumab|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preop Chemoradiation Resectable Pancreas
Status: COMPLETED
Conditions: Pancreatic Neoplasms
Interventions: DRUG: Avastin (Bevacizumab)|DRUG: Gemcitabine|PROCEDURE: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of XJ103 in Chinese Healthy Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Pneumococcal Disease
Interventions: DRUG: XJ103 Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peri -and Postoperative Drug Therapy Schedules for Morbidly Obese Patients
Status: COMPLETED
Conditions: Obese|Atracurium|Cefazolin|Morphine|Nadroparin
Interventions: DRUG: Atracurium, TBW
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation|Stroke
Interventions: DRUG: Apixaban|DRUG: aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Flow Regulation by Opening the Septum in Patients With Heart Failure Trial
Status: UNKNOWN
Conditions: Heart Failure With Normal Ejection Fraction
Interventions: DEVICE: AFR implantation|DEVICE: Sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Single Dose of Bright Light Treatment on Measures of Affective Information Processing
Status: COMPLETED
Conditions: Bright Light Treatment|Emotion|Facial Expression Recognition
Interventions: DEVICE: Bright light treatment lamp|DEVICE: Sham negative ion generator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Of Lybrel In Relation To Venous Thromboembolism
Status: COMPLETED
Conditions: Venous Thrombosis|Pulmonary Embolism|Sinus Thrombosis, Intracranial
Interventions: DRUG: 90ug levonorgestrel / 20 ug ethinyl estradiol|DRUG: Oral Contraceptives containing 20 ug of ethinyl estradiol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficiency of Botulinum Toxin Injection for Spastic Equinovarus Foot in Post Stroke Hemiparetic Patients
Status: COMPLETED
Conditions: Spastic Equinovarus Foot
Interventions: DRUG: Intra muscular injection of Botulinum toxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Joints Mobilization Versus Myofascial Release on Diabetic Patients With Painful Heel
Status: UNKNOWN
Conditions: Diabetic Foot|Plantar Fasciitis
Interventions: OTHER: Joint mobilization (JM)|OTHER: Myofascial release (MFR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Antihypertension Strategies-Carotid Artery Stenting
Status: NOT_YET_RECRUITING
Conditions: Carotid Stenosis
Interventions: DRUG: administering RASI (the trade name or universal name will not be stipulated) before stenting|DRUG: administering CCB (the trade name or universal name will not be stipulated) before stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Efficacy and Safety of a Subcutaneous Immunotherapy With gpASIT+™ in Patients With Grass Pollen-induced Allergic Rhinoconjunctivitis
Status: COMPLETED
Conditions: Hay Fever
Interventions: BIOLOGICAL: Placebo solution|BIOLOGICAL: gpASIT+TM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Tolerability, Including Gastrointestinal Safety, Pharmacokinetics and Pharmacodynamics of ASP7657 in Caucasian Healthy Male and Female Subjects
Status: TERMINATED
Conditions: Pharmacokinetics of ASP7657|Pharmacodynamics of ASP7657|Healthy Subjects
Interventions: DRUG: ASP7657|DRUG: Placebo|DRUG: naproxen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Optimisation of Controlled Human Malaria Infection Using Sporozoites Administered by Needle and Syringe
Status: COMPLETED
Conditions: Malaria|Plasmodium Falciparum
Interventions: BIOLOGICAL: Plasmodium falciparum sporozoites 2sites|BIOLOGICAL: Plasmodium falciparum sporozoites 1 site|BIOLOGICAL: Plasmodium falciparum sporozoites 1site
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Stress Management and Resiliency Training for Depression vs Treatment as Usual in the Treatment of Major Depression
Status: COMPLETED
Conditions: Major Depression
Interventions: BEHAVIORAL: Stress Management and Resiliency Training for Depression (SMART-D) Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy Study of Endothelial Progenitor Cell Capture Stent With 1 Months Dual Antiplatelet Therapy
Status: TERMINATED
Conditions: Stable Angina
Interventions: DEVICE: Endothelial cell capture stent with 1 month clopidogrel|DEVICE: Everolimus eluting stent with 12 month clopidogrel|DRUG: Atorvastatin 20mg loading|DRUG: Atorvastatin 80mg loading
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Ziprasidone in the Treatment of Bipolar I Depression
Status: COMPLETED
Conditions: Bipolar Disorder|Depression, Bipolar
Interventions: DRUG: Ziprasidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Clinical Outcomes in Robotic-Assisted Inguinal Hernia Repair
Status: COMPLETED
Conditions: Hernia, Inguinal|Hernia, Inguinal, Direct|Hernia, Inguinal, Indirect
Interventions: PROCEDURE: Inguinal Hernia Repair
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hydrogen Peroxide Fumigation in Dental Office Environment
Status: COMPLETED
Conditions: Bacterial Infections|Dental Caries|Aerosol Disease
Interventions: DIAGNOSTIC_TEST: Microbiological analysis after Caries treatment|DIAGNOSTIC_TEST: Microbiological analysis after Caries treatment and fumigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine Maximum Tolerated Dose of LErafAON Combined With Radiotherapy in Patients With Advanced Malignancies
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: LErafAON
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Defining Antibiotic Treatment Duration for Ventilator - Associated Lung Infection
Status: COMPLETED
Conditions: Ventilator Associated Pneumonia|Pneumonia, Bacterial
Interventions: DRUG: Reducing Antibiotics treatment duration|DRUG: Standard Antibiotics treatment duration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain
Status: UNKNOWN
Conditions: Postoperative Delirium|Postoperative Pain|Spinal Fusion
Interventions: DRUG: Lidocaine IV|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Biliary Forceps Biopsy and Brush Cytology
Status: COMPLETED
Conditions: Cholangiocarcinoma
Interventions: DEVICE: double-balloon enteroscopy forceps biopsy|DEVICE: Transpapillary brush cytology
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Quinoa Biscuit & CVD Risk Trial
Status: COMPLETED
Conditions: Cardiovascular Diseases|Dyslipidemias|Lipid Profile
Interventions: DIETARY_SUPPLEMENT: Quinoa biscuit|DIETARY_SUPPLEMENT: Control biscuit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Oncologic Therapy Support Via Means of a Dedicated Mobile App
Status: UNKNOWN
Conditions: Thoracic Neoplasm|Pelvic Neoplasm|Radiotherapy; Complications|Oncologic Disorders|Breast Cancer|Satisfaction|Quality of Life
Interventions: OTHER: mobile application
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Different Modalities of Exercise Training in COPD With Chronic Respiratory Failure (CRF)
Status: ACTIVE_NOT_RECRUITING
Conditions: Copd|Chronic Hypoxemic Respiratory Failure
Interventions: OTHER: Endurance Training|OTHER: Long High Intensity Interval Training|OTHER: Short High Intensity Interval Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photoactive Porphyrins (PAP) Levels After Topical Visonac Application in Acne Patients
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Area cleaned with saline water and occluded with Tegaderm|DRUG: Area cleaned with saline water|DRUG: Area cleaned with Ethyl alcohol solution|DRUG: Visonac left on the skin for 24 hours in facial area one|DRUG: Visonac wiped off after one hour|DRUG: Visonac left on the skin 24 hours in facial area two
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Visceral Manifold Study for the Repair of TAAA
Status: ACTIVE_NOT_RECRUITING
Conditions: Thoracoabdominal Aortic Aneurysms
Interventions: DEVICE: TAAA Debranching Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zanubrutinib, Lenalidomide and Rituximab (ZR2) in Elderly Treatment-naive Patients with Diffuse Large B-cell Lymphoma (DLBCL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Diffuse Large B Cell Lymphoma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Orally Pilocarpine and Artificial Saliva in Xerostomy Treatment
Status: COMPLETED
Conditions: Primary Sjogren|Secondary Sjogren|Xerostomia
Interventions: PROCEDURE: pilocarpine|DRUG: Artificial Saliva
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Finding Study Of CP-870,893, An Immune System Stimulating Antibody, In Combination With Paclitaxel And Carboplatin For Patients With Metastatic Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Paclitaxel + Carboplatin + CP-870,893|DRUG: Paclitaxel + Carboplatin + CP-870,893
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tailored Therapy for Helicobacter Pylori Treatment in Patients With Penicillin Allergy
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Esomeprazole|DRUG: Bismuth Potassium Citrate|DRUG: Clarithromycin|DRUG: Metronidazole|DRUG: Levofloxacin|DRUG: Tetracycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Momentary Affect Regulation - Safer Sex Intervention
Status: COMPLETED
Conditions: Teen Pregnancy Prevention
Interventions: BEHAVIORAL: Momentary Affect Regulation - Safer Sex Intervention (MARSSI)|BEHAVIORAL: Podcast Health Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Perioperative Administration of Pregabalin for Pain After Mastectomy
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Pregabalin|DRUG: Vitamin Complex (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Lymphomas
Status: COMPLETED
Conditions: Diffuse Large B-Cell Lymphoma|Follicular Lymphoma
Interventions: DRUG: Ibrutinib|DRUG: MEDI4736
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Rectal Indomethacin in Prevention of Post-pancreatectomy Acute Pancreatitis
Status: NOT_YET_RECRUITING
Conditions: Pancreatectomy
Interventions: DRUG: Indomethacin suppository|OTHER: Standard Medical Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Cemdisiran in Adults With Immunoglobulin A Nephropathy (IgAN)
Status: TERMINATED
Conditions: IgA Nephropathy (IgAN)|Berger Disease|Glomerulonephritis, IgA
Interventions: DRUG: Placebo|DRUG: Cemdisiran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Oral Vismodegib in Combination With Pirfenidone in Participants With Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Pirfenidone|DRUG: Vismodegib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of 89Zr Panitumumab and (18)F-Fluorodeoxyglucose to Identify Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: [89Zr]Panitumumab Tracer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Some Biochemical Markers of Bone Turnover in Childern and Adolescents With Type 1 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Type 1 Diabetes
Interventions: DIAGNOSTIC_TEST: serum ostecalcin,serum sclerostin and parathroid profile
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess Efficacy, Safety, Tolerability and Pharmacokinetics of Simeprevir, Daclatasvir and Sofosbuvir in Treatment-naive Participants With Chronic Hepatitis C Virus Genotype 1 Infection
Status: COMPLETED
Conditions: Hepatitis C Virus
Interventions: DRUG: Simeprevir 150 mg|DRUG: Daclatasvir 60 mg|DRUG: Sofosbuvir 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The KHENEREXT Study
Status: COMPLETED
Conditions: Mitochondrial Diseases|Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation|Maternally Inherited Diabetes and Deafness (MIDD)|Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke Like Episodes (MELAS)|Chronic Progressive External Ophthalmoplegia (CPEO)
Interventions: DRUG: Oral administration of 100 mg KH176 twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Warmed, Humidified Carbon Dioxide Insufflation vs Standard Carbon Dioxide in Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Cholecystolithiasis
Interventions: DEVICE: Optitherm® device activated|DEVICE: Optitherm® device inactivated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Delayed Cord Clamping and Umbilical Cord Milking During Elective Cesarean Section for the Neonatal Outcome
Status: COMPLETED
Conditions: Umbilical Cord Milking
Interventions: PROCEDURE: Delayed cord clamping for 30 seconds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Clinical Trial on Sequential Immunization of Recombinant COVID-19 Vaccine (CHO Cell, NVSI-06-09) and Inactivated COVID-19 Vaccine (Vero Cell)
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: Recombinant COVID-19 Vaccine (CHO cell，NVSI-06-09)|BIOLOGICAL: Inactivated COVID-19 vaccine (Vero cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of HRS-7535 Tablets in T2DM Subjects Poorly Controlled With Metformin and SGLT2i.
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: HRS-7535|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Prospective Monitoring of Antibody Response Following COVID-19 Vaccination in Patients With Down Syndrome.
Status: UNKNOWN
Conditions: Down Syndrome|SARS-CoV-2 Vaccination
Interventions: BIOLOGICAL: Immune response to Sars-CoV-2 vaccinations; including COVID-19 vaccin Moderna, Comirnaty (Pfizer) and Vaxzevria (AstraZeneca)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Trial Study to Evaluate Efficacy and Safety of Atorvastatin in Korean Patients With Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: atorvastatin|DRUG: atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Determining the Impact of a New Physiotherapist Led Primary Care Model for Back Pain
Status: COMPLETED
Conditions: Back Pain
Interventions: BEHAVIORAL: Physiotherapist-led primary care model for back pain|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy/Safety Study to Confirm Iberogast's Efficacy in Patients With Irritable Bowel Syndrome Diagnosed on ROME III Criteria Compared to Placebo
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: STW5 (Iberogast, BAY98-7411)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Simvastatin in Secondary Progressive Multiple Sclerosis
Status: COMPLETED
Conditions: Secondary Progressive Multiple Sclerosis
Interventions: DRUG: Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of RAT in Sequential Combination With CIT in Stroke Rehabilitation
Status: UNKNOWN
Conditions: Cerebrovascular Accident
Interventions: BEHAVIORAL: RT in sequential combination with dCIT|BEHAVIORAL: Distributed Constraint-Induced Therapy|BEHAVIORAL: Robot-Assisted Therapy|BEHAVIORAL: Dose-matched control therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vasopressin vs. Epinephrine During Neonatal Cardiopulmonary Resuscitation
Status: RECRUITING
Conditions: Cardiac Arrest Neonatal
Interventions: DRUG: Vasopressin|DRUG: Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3337641 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Reference Formulation (R)|DRUG: LY3337641 (T1)|DRUG: LY3337641 (T2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice Involved Women
Status: RECRUITING
Conditions: HIV|Opioid Use Disorder|eHealth
Interventions: BEHAVIORAL: Decision Aid|COMBINATION_PRODUCT: Athena strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment of Efficacy and Safety of Perifosine, Bortezomib and Dexamethasone in Multiple Myeloma Patients
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Perifosine|DRUG: Perifosine Placebo|DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT