pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Respiratory and Psychological Impact of Elective Surgery of Congenital Lung Malformations
Status: NOT_YET_RECRUITING
Conditions: Congenital Lung Malformations
Interventions: OTHER: General Health Questionnaire (GHQ-28)|OTHER: State-Trait Anxiety Inventory (STAI-Y)|OTHER: Revised Children's Manifest Anxiety Scale (RCMAS)|OTHER: World Health Organization Quality of Life (WHOQOL-BREF)|OTHER: Quality of life measure for children (KIDSCREEN-27)|OTHER: Parental Educational Competence Self-Evaluation Questionnaire "Questionnaire d'Auto-Évaluation de la Compétence Éducative Parentale (QAECEP)"|OTHER: Parental interview
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 7-days Versus 14 Days of Antibiotics Therapy for Ventilator Associated Pneumonia
Status: RECRUITING
Conditions: Ventilator Associated Pneumonia
Interventions: DRUG: Duration of antibiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of the NephroCheck™ After TAVI
Status: COMPLETED
Conditions: Transcatheter Aortic Valve Implantation|Acute Kidney Injury|Postoperative Acute Renal Failure
Interventions: PROCEDURE: Renal Resistive Index/NephroCheck™test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Methylphenidate in Children With Attention-deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Methylphenidate 20 mg long-acting capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zenith® AAA Endovascular Graft Clinical Study
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: DEVICE: Roll-in|DEVICE: Surgical|DEVICE: Standard Risk|DEVICE: High Risk|DEVICE: Compassionate Use|DEVICE: Treatment for females|DEVICE: Standard Risk Continued Access|DEVICE: High Risk Continued Access
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Japan Prevention Trial of Diabetes by Pitavastatin in Patients With Impaired Glucose Tolerance (J-PREDICT)
Status: COMPLETED
Conditions: Diabetes Mellitus|Glucose Intolerance
Interventions: OTHER: life-style intervention|DRUG: Life style interventions plus concomitant use of pitavastatin.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of ADCT-301 in Patients With Relapsed/Refractory CD25-positive Acute Myeloid Leukemia (AML) or CD25-positive Acute Lymphoblastic Leukemia (ALL)
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia
Interventions: DRUG: ADCT-301
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Sugammadex Administered at 1-2 Post Tetanic Counts (PTCs) or Better With Neostigmine Administered as Per Standard of Care to Reverse Rocuronium-Induced Neuromuscular Blockade in Adults Undergoing Elective Open Abdominal Procedure (19.4.334) (P05774)
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Sugammadex|DRUG: Neostigmine|DRUG: Rocuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Combination Oral Formulation of Hyaluronic Acid, Chondroitin Sulphate and Magnesium Trisilicate in Patients With Gastro-Esophageal Reflux Disease Not Fully Satisfied With Their Treatment
Status: COMPLETED
Conditions: Gastro Esophageal Reflux
Interventions: DEVICE: Hyaluronic acid with chondroitin sulphate and magnesium trisilicate, 1100 mg melt in mouth tablet|DEVICE: Placebo 1100 mg, identically-looking melt in mouth tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Comprehensive Molecular Tests on Antimicrobial Stewardship in Community-acquired Pneumonia
Status: TERMINATED
Conditions: Community-acquired Pneumonia
Interventions: DIAGNOSTIC_TEST: real-time multiplex PCR|DIAGNOSTIC_TEST: Standard diagnostic procedures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ground-Breaking Electroporation-based Intervention for PAROXysmal Atrial Fibrillation Treatment (BEAT PAROX-AF)
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: PVI using PEF|DEVICE: PVI using CFRF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: CAPTEM or FOLFIRI as SEcond-line Therapy in NEuroendocrine CArcinomas
Status: UNKNOWN
Conditions: Neuroendocrine Carcinoma
Interventions: DRUG: CPT-11|DRUG: Calcio levofolinate|DRUG: 5-Fluorouracil|DRUG: Capecitabine|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Rapid Diagnostic Solutions, Serological and Molecular Tests for COVID-19
Status: UNKNOWN
Conditions: SARS-CoV 2|COVID-19
Interventions: DEVICE: Taking blood samples (capillary and venous), saliva sampling and nasopharyngeal sampling.|DEVICE: Taking blood samples (capillary and venous), saliva sampling and nasopharyngeal sampling.|DEVICE: Capillary and salivary sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study in CKD Patients With Type 2 Diabetes Mellitus and Albuminuria
Status: COMPLETED
Conditions: Chronic Kidney Disease|Type 2 Diabetes Mellitus
Interventions: DRUG: AZD1722|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does an Occupational Therapy Program Enhance Mental Health Outcomes for Veterans Who Scuba Dive
Status: COMPLETED
Conditions: Post Traumatic Stress Disorder|Depression|Anxiety|Stress, Psychological
Interventions: BEHAVIORAL: SCUBA with Occupational Therapy (OT)|BEHAVIORAL: Self-Contained Underwater Breathing Apparatus (SCUBA) without OT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Ultrasound Radiofrequency Ablation for GISTs
Status: RECRUITING
Conditions: Gastrointestinal Stromal Tumor (GIST)
Interventions: PROCEDURE: Endoscopic ultrasound guided radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Peripheral Laser Iridotomy Placement on Post-operative Visual Function
Status: UNKNOWN
Conditions: Glaucoma, Angle-Closure
Interventions: PROCEDURE: Superior laser peripheral iridotomy|PROCEDURE: Temporal laser peripheral iridotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Computed Tomography as the First-Choice Diagnostics in High Pre-Test Probability of Coronary Artery Disease
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: OTHER: Cardiac CT as the first diagnostic modality in suspected CAD|OTHER: Invasive coronary angiography as indicated by the guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of MGUS, Smoldering Myeloma, Early MDS and CLL to Assess Molecular Events of Progression and Clinical Outcome
Status: RECRUITING
Conditions: Monoclonal Gammopathy of Undetermined Significance (MGUS)|Chronic Lymphocytic Leukemia (CLL)|Myelodysplastic Syndromes|Hematological Malignancies|B-cell Malignancy, Low-grade|Myelodysplastic Syndrome With Low-grade Lesions|IgG Monoclonal Gammopathy of Uncertain Significance|Smoldering Multiple Myeloma|Waldenstrom Macroglobulinemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prognostic Value of Prothrombin Fragments 1+2 for Pulmonary Embolism Incidence
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive|Disease Exacerbation|Pulmonary Embolism|Prothrombin Fragments
Interventions: OTHER: CT pulmonary angio, blood tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: HORIZONS: Understanding the Impact of Cancer Diagnosis and Treatment on Everyday Life
Status: UNKNOWN
Conditions: Breast Cancer Female|Breast Neoplasm|Non-Hodgkin's B-cell Lymphoma|Non-Hodgkin's Lymphoma, Adult High Grade|NonHodgkin Lymphoma|Diffuse Large B Cell Lymphoma|Diffuse Large Cell Lymphoma, Adult|Ovarian Cancer|Ovarian Neoplasm|Endometrial Cancer|Endometrial Neoplasms|Cervical Cancer|Cervical Neoplasm|Primary Peritoneal Carcinoma|Fallopian Tube Cancer|Fallopian Tube Neoplasms|Vulvar Cancer|Vulvar Neoplasms
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: End-of-life Decision-making in Patients With Sepsis-related Organ Failure
Status: COMPLETED
Conditions: Severe Sepsis
Interventions: BEHAVIORAL: SOPs for decision-making and communication
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effects of an Integrated Mindfulness-based Tai Chi Chuan Program on Sleep Disturbance Among Community-dwelling Elderly People
Status: RECRUITING
Conditions: Elderly|Sleep|Mindfulness|Tai Chi Chuan
Interventions: BEHAVIORAL: Integrated mindfulness-based Tai Chi Chuan|BEHAVIORAL: Mindfulness-based intervention|BEHAVIORAL: Tai Chi Chuan|BEHAVIORAL: Sleep Hygiene Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Rituximab in Treating Patients With Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: fludarabine phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PhaseⅠ/Ⅱ Study of URLC10-177 and TTK-567 Peptide Vaccine Combined With CpG7909 in Patients With Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: BIOLOGICAL: URLC10-177, TTK-567, CpG-7909
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating a New Program for Successfully Coping With Adversity
Status: UNKNOWN
Conditions: Trauma|Distress, Emotional|Psychological Distress
Interventions: OTHER: Program to Support Well-Being after Adversity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Non-invasive Assessment of Inflammatory Markers MIP-1 Alpha and IL-6 in Saliva of Post Myocardial Infarction and Stage 4 Periodontitis Patients
Status: COMPLETED
Conditions: Myocardial Infarction|Periodontal Diseases
Interventions: DIAGNOSTIC_TEST: salivary test|DIAGNOSTIC_TEST: salivary test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Orall Administered Probiotics to Improve the Quality of the Vaginal Flora of Women With Breast Cancer and Chemotherapy.
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DIETARY_SUPPLEMENT: Probiotics|DIETARY_SUPPLEMENT: Oral lactose placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Food Combination on Starch Digestion and Gastric Processing
Status: COMPLETED
Conditions: Glycemic Index|Gastric Emptying|Appetite
Interventions: OTHER: Bread|OTHER: Water|OTHER: Lemon juice|OTHER: Tea|OTHER: Peas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Does Preventive Uterine Artery Occlusion During Laparoscopic Myomectomy Impact on Ovarian Reserve Markers?
Status: COMPLETED
Conditions: Uterine Myoma
Interventions: PROCEDURE: uterine myomectomy with preventive uterine arteries occlusion|PROCEDURE: laparoscopic uterine myomectomy without preventive uterine arteries occlusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dietary Habits and Metabolic Response in Obese Children Whose Mothers Received an Intervention to Promote Healthy Eating
Status: COMPLETED
Conditions: Obesity|Child Obesity
Interventions: BEHAVIORAL: Family intervention|OTHER: Usual nutritional consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Efficacy of Different Iron Formulations: Sucrosomal Ferric Pyrophosphate, SunActive®Fe and Intravenous Ferric Gluconate
Status: COMPLETED
Conditions: Iron Deficiency Anemia
Interventions: DIETARY_SUPPLEMENT: SunActive®Fe|DIETARY_SUPPLEMENT: Lipofer®|DIETARY_SUPPLEMENT: Intravenous ferric gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-Blind, Placebo Controlled Study of Vilazodone's Efficacy, Safety, and Biomarkers of Response in Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: vilazodone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Developing a Smoking Cessation Intervention for Methadone Maintained Smokers
Status: COMPLETED
Conditions: Nicotine Dependence|Opiate Dependence
Interventions: BEHAVIORAL: Intensive, tailored intervention|BEHAVIORAL: NJ Quitline Referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: De-adopting Routine Preoperative Benzodiazepines for Older Surgical Patients
Status: COMPLETED
Conditions: Surgery|Aging
Interventions: BEHAVIORAL: Peer Comparison Feedback|BEHAVIORAL: Patient Informational Letter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Caudal Block and Retrolaminar Block for Circumcision
Status: RECRUITING
Conditions: Regional Anesthesia
Interventions: PROCEDURE: caudal block|PROCEDURE: Retrolaminar block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: L-arginine in Treatment of Intrauterine Growth Restriction
Status: UNKNOWN
Conditions: Intrauterine Growth Restriction Asymmetrical
Interventions: DRUG: L-arginine 1000 mg and Acetylesalicylic acid75mg|DRUG: acetylsalicylic acid 75 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: ACT-280778|DRUG: Placebo|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Polypharmacy in the Heart Failure Patient: Are All Prescribed Drug Classes Required? Statin Withdrawal Study
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Withdrawal of statin therapy|DRUG: Statin therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mg Wire for Augmentation of ACL Reconstruction
Status: NOT_YET_RECRUITING
Conditions: Anterior Cruciate Ligament Rupture
Interventions: DEVICE: Magnesium based wire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Isosorbide Diesters Based Moisturizer on Skin Health
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: OTHER: Moisturizer Containing Isosorbide Diesters and Colloidal Oatmeal|OTHER: Moisturizer containing Colloidal Oatmeal only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chlorhexidine as Coadjuvant in Dentin Adhesion of Noncarious Cervical Lesions
Status: COMPLETED
Conditions: Non-carious Cervical Lesions
Interventions: PROCEDURE: Treatment with chlorhexidine|PROCEDURE: Water pre-treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Efficacy and Tolerability Trial of the Fixed Dose Combination of Etodolac 400 mg and Cyclobenzaprine 10 mg Versus Isolated Active Substances in Pain Control After Impacted Third Molar Extraction
Status: TERMINATED
Conditions: Pain, Acute
Interventions: DRUG: Fixed Dose Combination|DRUG: Etodolac|DRUG: Cyclobenzaprine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Self Assembling Peptide P11-4 in Patients With Early Occlusal Carious Lesions
Status: COMPLETED
Conditions: Dental Caries
Interventions: DEVICE: self assembling peptide P11-4 (Curodont™ Repair)|DEVICE: fluoride varnish (Duraphat®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Validation of Esophageal Variceal Grading: A Comparative Study of Upper Gastrointestinal (GI) Endoscopy and Capsule Endoscopy
Status: WITHDRAWN
Conditions: Esophageal and Gastric Varices
Interventions: DEVICE: Esophageal Capsule Endoscopy|DEVICE: Upper Gastrointestinal Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Registry of the German CLL Study Group
Status: RECRUITING
Conditions: CLL|SLL|HCL|Richter´s Transformation|Leukemia, Prolymphocytic, B-Cell|Leukemia, Prolymphocytic, T-Cell|T-LGL Leukemia|NK-LGL Leukemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Calcium: Magnesium Balance, Microbiota, and Necroptosis and Inflammation
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: Magnesium glycinate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Noninvasive Dual-mode Stimulation Therapy for Neurorehabilitation in Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Dual-mode stimulation|DEVICE: Single sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety of SonoVue on Pulmonary Hemodynamics
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: SonoVue|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Rapid Renal Sympathetic Denervation for Resistant Hypertension II
Status: WITHDRAWN
Conditions: Resistant Hypertension|Uncontrolled Hypertension|Renal Artery Ablation
Interventions: DEVICE: Renal Denervation (OneShot™ Renal Denervation System)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CLE-100 (Oral Esketamine) in Addition to Standard Antidepressant Drug for Major Depressive Disorder - CLEO Study
Status: COMPLETED
Conditions: Adjunctive Treatment of Major Depressive Disorder
Interventions: DRUG: CLE-100|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Patients With High-risk Acute Coronary Syndrome Without ST-segment Elevation
Status: TERMINATED
Conditions: Non ST Segment Elevation Myocardial Infarction|Unstable Angina
Interventions: DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Life STORRIED Study
Status: COMPLETED
Conditions: Opioid Dependence|Communication|Risk Behavior|Narrative Medicine
Interventions: OTHER: Probabilistic Risk Communication Tool (PRT)|OTHER: Narrative Enhanced Risk Tool (NERT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Tapentadol Versus Oxycodone After Hysterectomy.
Status: COMPLETED
Conditions: Pain, Postoperative|Pain Uterus|Pain, Acute|Opioid Use|Analgesics, Antipyretics, and Antirheumatics Causing Adverse Effects in Therapeutic Use|Visceral Pain
Interventions: DRUG: Tapentadol|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of GSK Biologicals' DTaP-IPV Candidate Vaccine to DTaP and IPV Separately Administered Vaccines in Terms of Immune Response and Safety
Status: COMPLETED
Conditions: Diphtheria|Acellular Pertussis|Tetanus
Interventions: BIOLOGICAL: Prophylaxis: Diphtheria, tetanus, pertussis, poliovirus type 1, type 2 and type 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: EZ-blocker Versus Left Sided Double Lumen Tube in Adult Patients for Thoracic Surgery
Status: COMPLETED
Conditions: Thoracic Injuries
Interventions: DEVICE: EZ-Blocker|DEVICE: DLT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of SJ733 in Adults With Uncomplicated Plasmodium Falciparum or Vivax Malaria
Status: COMPLETED
Conditions: Malaria, Falciparum|Malaria, Vivax
Interventions: DRUG: (+)-SJ000557733 (SJ733)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of SBRT and Docetaxel for Locally Recurrent or Second Primary Squamous Cell Carcinoma of the Head and Neck
Status: TERMINATED
Conditions: Head and Neck Cancer
Interventions: DRUG: Docetaxel|RADIATION: Stereotactic Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regional Anesthesia for Arteriovenous Fistula
Status: WITHDRAWN
Conditions: Arteriovenous Fistula
Interventions: PROCEDURE: Axillary Block with 0.5% Ropivicaine|PROCEDURE: Stellate ganglion block with 0.2% Ropivicaine|PROCEDURE: Local anesthetic infiltration with 0.25% Bupivicaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid
Status: COMPLETED
Conditions: Melasma
Interventions: PROCEDURE: Jessner's solution chemical peel|PROCEDURE: Trichloroacetic acid chemical peel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Whole Body Vibration Therapy on Pain, Muscle Strength, Balance and Quality of Life in Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Osteoarthritis
Interventions: DEVICE: Whole Body Vibration|DEVICE: physical therapy modalities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Brentuximab Vedotin (Recombinant) for IV Infusion - Special Drug Use Surveillance (All-case Surveillance) "Relapsed or Refractory CD30+ Hodgkin's Lymphoma or Anaplastic Large Cell Lymphoma"
Status: COMPLETED
Conditions: Relapsed or Refractory CD30+ Hodgkin's Lymphoma or Anaplastic Large Cell Lymphoma
Interventions: DRUG: Brentuximab vedotin (recombinant)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Bioequivalence Study Comparing a Single 1.5mL Dose of Brodalumab vs. Two Doses (1.0mL + 0.5mL) of Brodalumab
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Brodalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study for JNS001 in Adults With Attention-Deficit Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention-Deficit Hyperactivity Disorder
Interventions: DRUG: JNS001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of the Use of ME-APDS During Colonoscopy
Status: COMPLETED
Conditions: Screening Colonoscopy|Surveillance Colonoscopy
Interventions: PROCEDURE: Screening or Surveillance Conventionall colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Comparison of the Clinical Effects of Two Tear Substitutes in Patients With Dry Eye Syndrome
Status: UNKNOWN
Conditions: Dry Eye
Interventions: DRUG: Liposic|DRUG: Tears Naturale Forte
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Raltegravir vs. Atazanavir in Combination With Truvada® for the Treatment of Antiretroviral naïve HIV Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Raltegravir and truvada|DRUG: Atazanavir, Norvir and Truvada
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin E on Non-Alcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Healthy|NAFLD (Non-Alcoholic Fatty Liver Disease)|NASH (Non-Alcoholic Steatohepatitis)
Interventions: OTHER: NAFLD/NASH - Placebo|DIETARY_SUPPLEMENT: NAFLD/NASH - Vitamin E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Immune Response After Booster Vaccination With Tdap-IPV Vaccine (Against Tetanus, Diphtheria, Pertussis and Poliomyelitis) in Children Who Received Different Pertussis Primary Vaccine Regimens in Republic of South Africa
Status: COMPLETED
Conditions: Pertussis Immunisation|Diphtheria Immunisation|Tetanus Immunisation|Poliomyelitis Vaccine
Interventions: BIOLOGICAL: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed Combined with Inactivated Poliomyelitis Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Therapy for Pneumonia Patients iInfected by 2019 Novel Coronavirus
Status: WITHDRAWN
Conditions: COVID-19
Interventions: BIOLOGICAL: UC-MSCs|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hamstrings X Patellar Tendon for ACL Reconstruction in Soccer Players - RCT
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injuries
Interventions: PROCEDURE: Patellar Tendon graft|PROCEDURE: Hamstring Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Liraglutide Compared to Glimepiride on Appetite in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: placebo|DRUG: placebo|DRUG: glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-Blind Trial to Evaluate Efficacy and Safety of Cannabidiol as an add-on Therapy for Treatment in Refractory Epilepsy
Status: ACTIVE_NOT_RECRUITING
Conditions: Epilepsy
Interventions: DRUG: Cannabidiol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PARP Inhibition, Stereotactic Body Radiotherapy and Immunotherapy for Metastatic or Advanced Sarcoma (PRIMA)
Status: RECRUITING
Conditions: Sarcoma|Sarcoma,Soft Tissue|Sarcoma of Bone
Interventions: COMBINATION_PRODUCT: Camrelizumab and fluzoparib with concurrent stereotactic body radiotherapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Genetic Variation in CYP2D6 on the Pharmacokinetics and Pharmacodynamics of Methamphetamine
Status: WITHDRAWN
Conditions: Methamphetamine Metabolism, CYP2D6 Genotype
Interventions: DRUG: A single oral 5 mg of duterium labeled methamphetamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ph 1b Study to Evaluate GSK2110183 in Combination With Bortezomib and Dexamethasone in Subjects With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: GSK2110183|DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of the Optimal "Next Bolus" Interval for Programmed Intermittent Bolus Epidural Analgesia
Status: ACTIVE_NOT_RECRUITING
Conditions: Labor Pain
Interventions: OTHER: Next Bolus Interval
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of ETX-018810 in Subjects With Lumbosacral Radicular Pain
Status: COMPLETED
Conditions: Lumbosacral Radiculopathy
Interventions: DRUG: ETX-018810|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stand-Alone Cage Verus Anterior Plating for Anterior Cervical Discectomy and Fusion.
Status: WITHDRAWN
Conditions: Degenerative Disc Disease|Cervical Spine Degeneration
Interventions: DEVICE: Interbody Cage|DEVICE: Interbody Cage and Anterior Plating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Clinical Outcomes Using Two Insole Manufacture Techniques
Status: COMPLETED
Conditions: Foot Injury|Foot Deformity|Foot Sprain|Feet, Flat|Foot Ankle Injuries
Interventions: DEVICE: CAD/CAM insoles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Camostat Efficacy vs. Placebo for Outpatient Treatment of COVID-19 (CAMELOT)
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Camostat Mesilate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Open-label, Multiple-dose, Two-sequence, Two-period Crossover Study to Investigate The Pharmacokinetics Between a GL2907 and Oxycontin CR Tab. 10mg in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GL2907|DRUG: Oxycontine CR 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Promoting Teenage Sleep for Improved Mental Health and School Performance
Status: NOT_YET_RECRUITING
Conditions: Mental Health Issue|Insomnia|Depression|Anxiety|Daytime Sleepiness|Wellness, Psychological
Interventions: BEHAVIORAL: Sleep on Schedule|BEHAVIORAL: Technology restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Weight Loss Using the Take Shape For Life Program or the Medifast Direct Program Versus a Self-Directed Diet
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: OTHER: Take Shape For Life Program|OTHER: Medifast Direct Program|OTHER: Self-directed Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation in Obesity and Weight Loss (3DD Study)
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DIETARY_SUPPLEMENT: 600 IU Vitamin D3|DIETARY_SUPPLEMENT: 2000 IU Vitamin D3|DIETARY_SUPPLEMENT: 4000 IU Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Assessment of Switching From Salmeterol/Fluticasone to Indacaterol/Glycopyrronium in a symtomaticCOPD Patient Cohort
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: QVA149 110/50 micrograms|DRUG: Salmeterol/fluticasone 50/500 microgrammes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Preoperative Intravenous Ferric Carboxymaltose for Clipping Surgery
Status: UNKNOWN
Conditions: Cerebral Aneurysm Unruptured|Iron Deficiency Anemia|Surgery
Interventions: DRUG: FEFINJECT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CT Coronary Angiography for Type 2 Myocardial Infarction
Status: RECRUITING
Conditions: Myocardial Infarction|Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: CT coronary angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Lobectomy-First vs. Lymphadenectomy-First for Operable NSCLC (LOFTY)
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: PROCEDURE: Lobectomy-First|PROCEDURE: Lymphadenectomy-First
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home-based Cardiac Rehabilitation: Compliance and Effectiveness
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Disease|Cardiac Disease
Interventions: OTHER: Home-based Rehab|OTHER: CentreRehab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 18-FDG PET/CT Imaging and Clinical Decisions in Infective Endocarditis
Status: COMPLETED
Conditions: Infective Endocarditis
Interventions: PROCEDURE: 18-FDG PET/CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Vitamin D and Calcium Supplementation on the Prevention of Recurrences in BPPV
Status: COMPLETED
Conditions: Benign Paroxysmal Positional Vertigo
Interventions: DRUG: 400IU cholecalciferol and 500mg of elemental calcium as calcium carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Hemathologic and Imagiologic Predictors of Stroke During Carotid Endarterectomy With Regional Anesthesia
Status: UNKNOWN
Conditions: Carotid Stenosis|Carotid Endarterectomy
Interventions: DIAGNOSTIC_TEST: Biomarker - FGF 23; troponin I; PCR - high sensitivity; BNP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Antioxidant Vitamins on Coagulopathy and Nosocomial Pneumonia After Severe Trauma
Status: TERMINATED
Conditions: Coagulopathy|Nosocomial Pneumonia
Interventions: DIETARY_SUPPLEMENT: Vitamin C|DIETARY_SUPPLEMENT: Vitamin E|DIETARY_SUPPLEMENT: Saline (for Vitamin C)|DRUG: Placebo (for Vitamin E)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Therapy for the Treatment of Diffuse Midline Gliomas
Status: RECRUITING
Conditions: Diffuse Intrinsic Pontine Glioma|Diffuse Midline Glioma, H3 K27M-Mutant|Recurrent Diffuse Intrinsic Pontine Glioma|Recurrent Diffuse Midline Glioma, H3 K27M-Mutant|Recurrent WHO Grade III Glioma|WHO Grade III Glioma
Interventions: DRUG: ONC201|RADIATION: Radiation Therapy|DRUG: Paxalisib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Investigate Immune Responses Elicited by a Liquid Formulation of Influenza Virus Vaccine, Trivalent, Types A & B, Live Cold Adapted (CAIV-T) in Healthy Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: CAIV-T
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Effect of Folic Acid, Vitamin B6 and Vitamin B12 in Diabetic Retinopathy
Status: UNKNOWN
Conditions: Non Proliferative Diabetic Retinopathy|Proliferative Diabetic Retinopathy
Interventions: DRUG: Folic Acid, vit B6 and B12|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Effectiveness and Safety of Luspatercept in Patients Suffering From Lower-risk Myelodysplastic Syndrome.
Status: RECRUITING
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Luspatercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CHARACTERISE - A Cross-sectional, Observational Study to Characterise the Transition to Dolutegravir-based Regimens in South Africa in Terms of the Emergence of Obesity, Viral Re-suppression and Integration Into Routine Programme Care
Status: COMPLETED
Conditions: Dolutegravir
Interventions: BEHAVIORAL: CHARACTERISE
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar Depression
Status: SUSPENDED
Conditions: Bipolar Disorder|Bipolar Depression
Interventions: DIETARY_SUPPLEMENT: N-acetylcysteine|DRUG: Minocycline|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Application of HAIC in Advanced HCC Previously Treated With ICIs and Antiangiogenic Agents
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: digital subtraction angiography.|DRUG: FOLFOX (oxaliplatin , leucovorin , fluorouracil , and fluorouracil )
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study About the Natural History in Adults With BAG3 Dilated Cardiomyopathy (a Type of Heart Disease) (BAG3 DCM)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiomyopathy, Dilated|Bcl-2 Anathogene-3 (BAG3) Dilated Cardiomyopathy (DCM)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Screening and Intervention of Postextubation Dysphagia
Status: COMPLETED
Conditions: Oropharyngeal Dysphagia|Swallowing Disorder|Randomized Controlled Trial|Endotracheal Intubation
Interventions: BEHAVIORAL: SOC program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Single Injection of BMAC vs HA in the Treatment of the Ankle Osteoarthritis
Status: RECRUITING
Conditions: Ankle Osteoarthritis
Interventions: PROCEDURE: BMAC|PROCEDURE: HA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trials of Autologous Cultured Adipose-derived Stem Cells (ANTG-ASC) on Complex Fistula
Status: TERMINATED
Conditions: Complex Perianal Fistula
Interventions: BIOLOGICAL: Autologous cultured adipose derived stem cells(low dose group)|BIOLOGICAL: Autologous cultured adipose derived stem cells(high dose group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study to Evaluate the Clinical Outcome of the OmniTaper EV Implant in Single Tooth Restorations
Status: ACTIVE_NOT_RECRUITING
Conditions: Jaw, Edentulous
Interventions: DEVICE: OmniTaper EV implants
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) vs. Brentuximab Vedotin in Participants With Relapsed or Refractory Classical Hodgkin Lymphoma (MK-3475-204/KEYNOTE-204)
Status: ACTIVE_NOT_RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: BIOLOGICAL: pembrolizumab|BIOLOGICAL: brentuximab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo Versus SBR759 in Lowering Phosphate in Dialysis Patients
Status: COMPLETED
Conditions: Hyperphosphatemia|Chronic Kidney Disease
Interventions: DRUG: SBR759A|DRUG: SBR759A|DRUG: SBR759A|DRUG: SBR759A|DRUG: SBR759A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Dapagliflozin and Gemigliptin on Ketone Metabolism and Cardiac Remodeling in Type 2 Diabetes
Status: RECRUITING
Conditions: Type2 Diabetes|Remodeling, Ventricular
Interventions: DRUG: Dapagliflozin|DRUG: Gemigliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studies of Empagliflozin and Its Cardiovascular, Renal and Metabolic Effects
Status: COMPLETED
Conditions: Heart Failure|Diabetes Mellitus
Interventions: DRUG: Empagliflozin 10 MG|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MTNR1B SNP*Food Timing Interaction on Glucose Control
Status: UNKNOWN
Conditions: Non-Diabetic Disorder of Endocrine Pancreas
Interventions: BEHAVIORAL: Early OGTT|BEHAVIORAL: Late OGTT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Effects of Age and Gender on the Pharmacokinetics of JNJ-42847922 in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-42847922 10 milligram (mg)|DRUG: JNJ-42847922 20 mg|DRUG: JNJ-42847922 40 mg|DRUG: JNJ-42847922 60 or 80 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Determine Fructose Uptake by Primary Human Colorectal Tumors
Status: RECRUITING
Conditions: Colorectal Tumors
Interventions: DIETARY_SUPPLEMENT: Cohort 1: HFCS (fructose) fed|DIETARY_SUPPLEMENT: Cohort 2: D-Xylose (xylose-fed)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Safety and Efficacy of AJM300 in Participants With Active Ulcerative Colitis
Status: COMPLETED
Conditions: Colitis, Ulcerative
Interventions: DRUG: AJM300|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of 2 Doses of ZD6474 (Vandetanib) in Combination With FOLFOX vs FOLFOX Alone for the Treatment of Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal|Cancer
Interventions: DRUG: Vandetanib|DRUG: FOLFOX regimen=oxaliplatin, fluorouracil, & folinic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing
Status: RECRUITING
Conditions: Chronic Pancreatitis|Chronic Pain
Interventions: DIAGNOSTIC_TEST: Quantitative Sensory Test 1|DIAGNOSTIC_TEST: Quantitative Sensory Test 2|DIAGNOSTIC_TEST: Quantitative Sensory Test 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC