pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Analgesic Efficacy of Intravenous Dexmedetomidine for Supraclavicular Plexus Block
Status: COMPLETED
Conditions: Surgery
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fulvestrant and Anastrozole as Consolidation Therapy in Postmenopausal Women With Advanced Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer|Postmenopausal Women
Interventions: DRUG: fulvestrant (Faslodex)|DRUG: anastrozole (Arimidex)|DRUG: Bevacizumab (Avastin)|DRUG: Best supportive care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pioglitazone and Glimepiride Combination Therapy in Treating Subjects With Type 2 Diabetes Mellitus.
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Pioglitazone and Glimepiride|DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test BI 754091 Alone or in Combination With BI 836880 in People Who Have Advanced Anal Cancer
Status: WITHDRAWN
Conditions: Anal Canal Squamous Cell Carcinoma
Interventions: DRUG: BI 754091|DRUG: BI 836880
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study to Determine the Maximum Tolerable Dose of BAY94-9343 in Patients With Advanced Solid Tumors.
Status: COMPLETED
Conditions: Oncology
Interventions: DRUG: BAY94-9343|DRUG: BAY94-9343 (Expansion)|DRUG: BAY94-9343 (1.8 mg/kg)|DRUG: BAY94-9343 (2.2 mg/kg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Ascertainment for Late Effects Among Survivors of Cancer, Tumor, or a Related Illness
Status: ACTIVE_NOT_RECRUITING
Conditions: Pediatric or Young Adult Cancer Survivors
Interventions: GENETIC: Family History Questionnaire (FHQ)|GENETIC: Salvia sample|OTHER: Blood sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Escitalopram in the Treatment of Premature Ejaculation
Status: UNKNOWN
Conditions: Premature Ejaculation
Interventions: DRUG: Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chronocort Versus Plenadren Replacement Therapy in Adults With Adrenal Insufficiency
Status: COMPLETED
Conditions: Primary Adrenal Insufficiency
Interventions: DRUG: Chronocort|DRUG: Plenadren
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise Program Combined or Not With Nutritional intErvention in Adults With tyPe 2 Diabetes
Status: COMPLETED
Conditions: Overweight|Obesity|Type 2 Diabetes
Interventions: BEHAVIORAL: Caloric restriction|BEHAVIORAL: Diet intervention and structured exercise training program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Women Informed to Screen Depending on Measures of Risk (Wisdom Study)
Status: RECRUITING
Conditions: Breast Cancer Screening|Breast Carcinoma in Situ|Breast Cancer
Interventions: OTHER: Complete a health questionnaire|DEVICE: Provide a saliva sample for genetic testing|OTHER: Screening advice based on a comprehensive risk assessment|OTHER: Screening advice based on a basic risk assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: iSLEEPms: An Internet-Delivered Intervention for Sleep Disturbance in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: iSLEEPms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gastrointestinal Physiological Conditions in Obesity and After Bariatric Surgery
Status: COMPLETED
Conditions: Obesity|Bariatric Surgery Candidate
Interventions: DEVICE: SmartPill in fasted state|DEVICE: SmartPill in fed state|OTHER: Aspiration|OTHER: Gastric emptying scintigraphy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Efficacy of PRP Injection in the Treatment of Rotator Cuff Syndrome
Status: COMPLETED
Conditions: Shoulder Pain|Musculoskeletal Diseases|Rotator Cuff Tendinopathy|Rotator Cuff Syndrome
Interventions: OTHER: Single PRP Injection|OTHER: Multiple PRP Injections|OTHER: Placebo Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AGItated Patients Management: intraNASAL Midazolam vs Intramuscular Loxapine
Status: TERMINATED
Conditions: Emergence Delirium
Interventions: DRUG: Intranasal midazolam|DRUG: Intramuscular loxapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lapatinib Ditosylate in Treating Patients With Ductal Breast Carcinoma In Situ
Status: COMPLETED
Conditions: Ductal Breast Carcinoma In Situ|HER2/Neu Positive
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Lapatinib Ditosylate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Weight and/or Obesity on Sulfamethoxazole and Trimethoprim Concentrations
Status: COMPLETED
Conditions: Obesity|Pharmacokinetics|MRSA|Tuberculosis|PCP
Interventions: DRUG: Sulfamethoxazole/trimethoprim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of a Preoperative Nerve Block on the Consumption of Sevoflurane
Status: COMPLETED
Conditions: Rotator Cuff Injury|Anesthesia; Functional
Interventions: DRUG: Ropivacaine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, PK/PD of (OriCAR-017) in Subjects With RR/MM - RIGEL Study
Status: RECRUITING
Conditions: Neoplasms, Plasma Cell|Neoplasms by Histologic Type|Neoplasms|Hemostatic Disorders|Vascular Diseases|Cardiovascular Diseases|Paraproteinemias|Blood Protein Disorders|Hematologic Diseases|Hemorrhagic Disorders|Lymphoproliferative Disorders|Immunoproliferative Disorders|Immune System Diseases|Multiple Myeloma
Interventions: DRUG: OriCAR-017
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuation Study of Entinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Neoplasms|Neoplasms, Glandular and Epithelial|Neoplasms by Histologic Type|Bronchial Neoplasms|Lung Neoplasms|Respiratory Tract Neoplasms|Thoracic Neoplasms|Digestive System Neoplasms|Endocrine Gland Neoplasms|Carcinoma, Non-Small-Cell Lung|Lung Diseases|Breast Diseases|Renal Neoplasm|Solid Tumors
Interventions: DRUG: Entinostat|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Three Intraocular Lenses Designed to Improve Distance, Intermediate and Near Vision Following Lens Extraction
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Crystalens AO|DEVICE: ReSTOR 3.0|DEVICE: AMO Tecnis Multifocal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nurse Led Ultrasound Guided Femoral Nerve Block in the Emergency Department
Status: COMPLETED
Conditions: Hip Fractures|Anesthesia|Femoral Neck Fractures
Interventions: PROCEDURE: Nurse-led femoral nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Respiratory Muscle Training in Stroke Swallowing Disorders
Status: TERMINATED
Conditions: Swallowing Disorder|Stroke|Respiratory Muscle Training|Malnutrition
Interventions: DEVICE: High intensity IEMT|DEVICE: Sham IEMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Fast Bar on Intermittent Fasting
Status: COMPLETED
Conditions: Fasting
Interventions: OTHER: Dinner|OTHER: Fasting|OTHER: Fast Bar|OTHER: Bar with Coffee|OTHER: Bar with Tea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Supplementary Angiographic Embolization for Peptic Ulcer Bleeding
Status: COMPLETED
Conditions: Peptic Ulcer Hemorrhage
Interventions: PROCEDURE: Angiographic embolization|PROCEDURE: Therapeutic endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of STIOLTO™ RESPIMAT® on Fatigue in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Stiolto Respimat|DRUG: Placebo Respimat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Risankizumab Long-term Remission Study
Status: RECRUITING
Conditions: Psoriasis
Interventions: DRUG: Risankizumab-Rzaa|PROCEDURE: Punch biopsies of the skin at baseline visit|PROCEDURE: Punch biopsies of the skin at week 28 visit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacitidine Combined to Epoetin Beta in International Prognostic Scoring System (IPSS) Low-risk and Intermediate-1 Myelodysplastic Syndrome (MDS) Patients, Resistant to Erythropoetin-stimulating Agents (ESA)
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Azacitidine|DRUG: Epoetin beta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: Neuromodulation eXperiment Testbed system (NEXT) stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Adherence to Walking on an Alter G Anti-Gravity Treadmill
Status: COMPLETED
Conditions: Severe Obesity
Interventions: DEVICE: unweighting using Alter-G Anti-Gravity Treadmill|DEVICE: normal weight using Alter-G Anti-Gravity Treadmill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Febuxostat for Lowering Uric Acid in NAFLD Patients With Gout
Status: UNKNOWN
Conditions: Nonalcoholic Fatty Liver Disease
Interventions: DRUG: febuxostat treatment|BEHAVIORAL: lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Peripheral Stem Cell Transplantation Followed By Immunotherapy in Treating Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Infection|Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: pneumococcal polyvalent vaccine|BIOLOGICAL: therapeutic autologous lymphocytes|BIOLOGICAL: therapeutic tumor infiltrating lymphocytes|DRUG: carmustine|DRUG: cyclophosphamide|DRUG: melphalan|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Low Level Laser Intervention for Individuals With Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Low level laser treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bipolar 15 Charrières Office Resectoscope : Polypectomy Without Anesthesia
Status: TERMINATED
Conditions: Polyps Uterus
Interventions: PROCEDURE: Polypectomy without anesthesia or analgo-sedation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Nicotine Salt Aerosol on Cigarette Smokers
Status: TERMINATED
Conditions: Electronic Cigarette Use
Interventions: OTHER: Subox Mini C with Avail 18 mg nicotine salt (protonated)|OTHER: Subox Mini C with Avail 18 mg nicotine (unprotonated)|OTHER: Own brand cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the OL-BF-001 for Severe Emphysema
Status: TERMINATED
Conditions: Emphysema
Interventions: DEVICE: OL-BF-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Web-Based Educational Program for Adults at Risk for Coronary Heart Disease (The Heart to Heart Feasibility Study)
Status: COMPLETED
Conditions: Coronary Disease|Cardiovascular Diseases
Interventions: BEHAVIORAL: Heart to Heart (Web-Based Decision Aid)|BEHAVIORAL: Physician Education Session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Lactobacillus Rhamnosus GG (ATCC 53103) in Mild-moderately Active UC Patients
Status: COMPLETED
Conditions: Ulcerative Colitis Chronic Mild|Ulcerative Colitis Chronic Moderate
Interventions: DIETARY_SUPPLEMENT: Lactobacillus rhamnosus GG ATCC 53103
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Induced Cardiopulmonary Injury in Humans
Status: TERMINATED
Conditions: Thoracic|Pulmonary Injury|Heart Injuries
Interventions: PROCEDURE: SPECT Lung Perfusion Scan|PROCEDURE: SPECT Heart Perfusion Scan|PROCEDURE: Pulmonary Function Tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Routine Physical Therapy With and Without Proprioceptive Neuromuscular Facilitation on Balance, Gait and Function in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: Proprioceptive Neuromuscular Facilitation|OTHER: Routine physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A RCT on Supraglottic Airway Versus Endotracheal Intubation in OHCA
Status: UNKNOWN
Conditions: Prehospital Airway Management in Patients With Cardiac Arrest
Interventions: DEVICE: supraglottic airway (SGA) V.S. endotracheal intubation (ETI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Letrozole vs. Letrozole Plus Zoledronic Acid as Endocrine Therapy Before Surgery in Postmenopausal Patients With Breast Cancer
Status: TERMINATED
Conditions: Breast Neoplasms
Interventions: DRUG: Letrozole|DRUG: Zolendronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Endocrine Therapy in ER-positive, HER2-negative Early Stage Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|HER2-negative Breast Cancer|Node-negative Breast Cancer|Breast Carcinoma
Interventions: DRUG: Anastrozole 1mg|DRUG: Letrozole 2.5mg|DRUG: Exemestane 25 mg|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Trans-facet Screw Fixation Under CT-scan Guidance for Remaining Symptoms at a Distance of Previous Spinal Surgery
Status: COMPLETED
Conditions: Spinal Stenosis|Spinal Disease|Zygapophyseal Joint Arthritis|Joint Instability|Arthrodesis|Laminectomy|Post Laminectomy Syndrome
Interventions: OTHER: Trans-Facet fixation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety and Efficacy of Obinutuzumab Compared With Placebo in Participants With Lupus Nephritis (LN)
Status: COMPLETED
Conditions: Lupus Nephritis
Interventions: DRUG: Mycophenolate Mofetil/Mycophenolic Acid|DRUG: Obinutuzumab|OTHER: Placebo|DRUG: Methylprednisolone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Administration of Anti Tim-3/CD123 CAR-T Cell Therapy in Relapsed and Refractory Acute Myeloid Leukemia (rr/AML)
Status: RECRUITING
Conditions: Acute Myeloid Leukemia Refractory|Acute Myeloid Leukemia, in Relapse
Interventions: DRUG: anti Tim-3/CD123 CAR-T cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iodine-125 Brachytherapy Together With Chemotherapy in Patients With Newly Diagnosed Glioblastoma
Status: UNKNOWN
Conditions: Glioblastoma
Interventions: OTHER: Iodine-125+Chemotherapy|OTHER: Surgical resection+Radiochemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Amniotic Fluid Index (AFI) on Maternal and Perinatal Outcomes in Pregnant Women With Preterm Premature Rupture of Membranes
Status: COMPLETED
Conditions: Premature Rupture of Membrane|Amniotic Fluid Leakage|Maternal Complication of Pregnancy|Fetal Complications
Interventions: OTHER: AFI via transabdominal ultrasonography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fibrin Sealant in Renal Transplantation
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DEVICE: Tisseelä fibrin sealant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Prevention of Cognitive Decline in ApoE4 Carriers With Subjective Cognitive Decline After EGCG and a Multimodal Intervention
Status: COMPLETED
Conditions: Alzheimer Disease|Cognitive Decline
Interventions: DIETARY_SUPPLEMENT: EGCG|DIETARY_SUPPLEMENT: Placebo EGCG|OTHER: Healthy lifestyle recommendations|OTHER: Multimodal lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess Effect of 8 Wks of Duloxetine Therapy on Breast Cancer Patients With Aromatase-Inhibitor Associated Pain
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Basal Insulins for Patients With Type 2 Diabetes on Anti-Hyperglycemic Medications (IOPE)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin Lispro Protamine Suspension|DRUG: Insulin Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaginal, Placental and Neonatal Buccal Mycobiota and Microbiome in Preterm Birth
Status: UNKNOWN
Conditions: Preterm Birth|Microbial Colonization
Interventions: DIAGNOSTIC_TEST: Collection of vaginal, neonatal buccal and placental samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Vasopressor on Pressure Injury Development
Status: COMPLETED
Conditions: Vasopressor Adverse Reaction|Pressure Injury|Pressure Ulcer
Interventions: DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Fentanyl Buccal Tablet for the Relief of Episodic Breathlessness in Cancer Patients
Status: COMPLETED
Conditions: Cancer|Dyspnea, Paroxysmal
Interventions: DRUG: Fentanyl|DRUG: Immediate release morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Male Subjects to Investigate Whether Administration of ACT-541468 Can Affect the Fate in the Body (Amount and Time of Presence in the Blood) of Rosuvastatin
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Rosuvastatin|DRUG: ACT-541468
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: I CAN DO Surgical ACP
Status: NOT_YET_RECRUITING
Conditions: Surgical Advanced Care Planning
Interventions: BEHAVIORAL: Letter, AD, PREPARE|BEHAVIORAL: Letter, AD, PREPARE, reminders|BEHAVIORAL: Letter, AD, PREPARE, reminders, healthcare navigator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Genetically Engineered Lymphocytes, Cyclophosphamide, and Aldesleukin in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma or Indolent B-Cell Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: B-cell Chronic Lymphocytic Leukemia|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Splenic Marginal Zone Lymphoma|Waldenström Macroglobulinemia
Interventions: BIOLOGICAL: therapeutic autologous lymphocytes|DRUG: cyclophosphamide|BIOLOGICAL: aldesleukin|GENETIC: polymerase chain reaction|GENETIC: gene rearrangement analysis|PROCEDURE: lymph node biopsy|BIOLOGICAL: genetically engineered lymphocyte therapy|PROCEDURE: bone marrow aspiration|OTHER: flow cytometry|OTHER: laboratory biomarker analysis|OTHER: enzyme-linked immunosorbent assay
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TGR-1202, a PI3K Delta Inhibitor, in Combination With Obinutuzumab and Chlorambucil in Patients With Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: TGR-1202 + Obinutuzumab + Chlorambucil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Adult Mesenchymal Stem Cells (MSC) to Treat Acute Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: BIOLOGICAL: Provacel|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Senior Adult Hepatobiliary Prehab Study
Status: RECRUITING
Conditions: Hepatobiliary Cancer|Cholangiocarcinoma|Liver Metastases
Interventions: BEHAVIORAL: Resistance Training|BEHAVIORAL: Aerobic Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pre-Test Genetic Education and Remote Genetic Counseling in Communicating Tumor Profiling Results to Patients With Advanced Cancer
Status: COMPLETED
Conditions: Advanced Malignant Neoplasm|Locally Advanced Malignant Neoplasm
Interventions: OTHER: standard genetic education|OTHER: Genetic Counseling|OTHER: Genetic Testing|OTHER: Internet-Based Intervention|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Gene Therapy Clinical Trial for the Treatment of Leber's Hereditary Optic Neuropathy Associated With ND1 Mutations
Status: RECRUITING
Conditions: Leber Hereditary Optic Neuropathy (LHON)
Interventions: DRUG: NFS-02 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prucalopride for Postoperative Ileus in Patients Undergoing Gastrointestinal Surgery
Status: COMPLETED
Conditions: Postoperative Ileus
Interventions: DRUG: Prucalopride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Radiotherapy in Thoracic Esophageal Squamous Cell Carcinoma With Neoadjuvant Chemoradiotherapy
Status: RECRUITING
Conditions: Radiation Oncology
Interventions: RADIATION: Neoadjuvant Radiotherapy Program:|DRUG: Neoadjuvant chemotherapy Program|PROCEDURE: Esophagectomy program:|RADIATION: Postoperative radiotherapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating 13-valent Pneumococcal Conjugate Vaccine Catch-Up Regimens in Older Infants and Children
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: 13-valent Pneumococcal Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Endothelin Receptor Antagonism in Coronary Artery Spasm
Status: NOT_YET_RECRUITING
Conditions: Coronary Spasm
Interventions: DRUG: Endothelin Receptor Antagonist|OTHER: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effects of Cyclosporine on the Pharmacokinetics and Safety of Canagliflozin (JNJ-28431754) in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Canagliflozin (JNJ-28431754)|DRUG: Cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Different Anesthesia Methods on Perioperative Neurocognitive Disorders in the Elderly
Status: UNKNOWN
Conditions: PND
Interventions: DEVICE: nerve block combined with general anesthesia|DEVICE: spinal anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of N-Acetylcysteine on Residual Renal Function in Chronic Hemodialysis Patients
Status: UNKNOWN
Conditions: Hemodialysis|Renal Failure
Interventions: DRUG: N-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Hyperglycemia in PAI-1 Activity and the Relationship With Outcome in Severe Sepsis and Septic Shock
Status: COMPLETED
Conditions: Severe Sepsis|Septic Shock
Interventions: PROCEDURE: intensive insulin therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Enteral Versus Parenteral Nutrition in the Conservative Treatment of Upper Gastrointestinal Fistula After Surgery
Status: TERMINATED
Conditions: Gastrointestinal Fistula|Enteral Nutritional Support
Interventions: OTHER: Enteral nutrition|OTHER: Parenteral nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Effects of Low Dose Apalutamide on Prostate-Specific Antigen (PSA) Levels in Men Scheduled for Removal of the Prostate Gland
Status: RECRUITING
Conditions: Localized Prostate Carcinoma|Prostate Adenocarcinoma|Stage I Prostate Cancer AJCC v8|Stage II Prostate Cancer AJCC v8
Interventions: DRUG: Apalutamide|PROCEDURE: Biospecimen Collection|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Galantamine and Memantine Combination for Cognitive Impairments in Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Galantamine ER|DRUG: Memantine XR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modulation of the Brain Excitatory/Inhibitory (E/I) Balance in Autism Spectrum Disorder (ASD)
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Arbaclofen_15|DRUG: Arbaclofen_30|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Postoperative Rehabilitation or Mobilization After Scoliosis Surgery
Status: COMPLETED
Conditions: Scoliosis Idiopathic|Scoliosis; Adolescence
Interventions: OTHER: Post-operative rehabilitation|OTHER: Post-operative mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Acute Montelukast in Asthma
Status: COMPLETED
Conditions: Acute Asthma Exacerbation
Interventions: DRUG: Montelukast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Intravenous Wharton's Jelly Derived Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome Due to COVID 19
Status: TERMINATED
Conditions: Acute Respiratory Distress Syndrome
Interventions: DRUG: Wharton's jelly derived Mesenchymal stem cells.|DRUG: Hydroxychloroquine, lopinavir/ritonavir or azithromycin and placebo (standard therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Retrovesical Colpopectinopexia
Status: UNKNOWN
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: laparoscopic retrovesical colpopectinopexia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kids FIRST: Family-based Intervention to Reduce Snacking and Screen Time in Children
Status: COMPLETED
Conditions: Sedentary Lifestyle|Sedentary Behavior|Diet Habit
Interventions: BEHAVIORAL: Kids FIRST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of SPX-303, a Bispecific Antibody Targeting LILRB2 and PD-L1 in Patients With Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor|HNSCC|RCC|CRC
Interventions: BIOLOGICAL: SPX- 303 Injection, a bispecific anti-LILRB2 / anti-PD-L1 Antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Frequent Sinus Infections in HIV-Infected Patients
Status: WITHDRAWN
Conditions: HIV Infections|Sinusitis
Interventions: DRUG: Pseudoephedrine hydrochloride|DRUG: Guaifenesin|DRUG: Cefuroxime axetil|DRUG: Beclomethasone dipropionate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Ketone Supplementation in Individuals With PTSD
Status: UNKNOWN
Conditions: PTSD|Ketosis
Interventions: DIETARY_SUPPLEMENT: Pruvit Ketomax Ketone Salt|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: How Orally Consumed 3-hydroxybuturate Alters Metabolism
Status: COMPLETED
Conditions: Acute Ketosis
Interventions: OTHER: 3-hydroxybuturate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Low Power Laser in Mandibular Third Molar Surgery
Status: COMPLETED
Conditions: Laser Therapy, Low-Level
Interventions: RADIATION: Grupo I- Lower laser fluency|RADIATION: Grupo II- Greater laser fluency|RADIATION: Grupo III- Laser sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevalence and Outcome of Brachial Artery Endothelial Function in Morbidly Obese Patients Undergoing Bariatric Surgery
Status: TERMINATED
Conditions: Obesity, Morbid|Ischemic Heart Disease
Interventions: OTHER: Measurement of flow mediated dilation of brachial artery.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose Finding Study to Assess Octenidine Mouthwash Concentrations in Comparison to Placebo
Status: COMPLETED
Conditions: Gingivitis
Interventions: DRUG: Octenidine dihydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laryngeal Reinnervation Versus Thyroplasty in Patients With Vocal Fold Weakness.
Status: COMPLETED
Conditions: Vocal Cord Paralysis Unilateral
Interventions: PROCEDURE: Thyroplasty|PROCEDURE: Reinnervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY2922083 in Healthy Participants and Participants With Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo|DRUG: LY2922083
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: European Transplant Registry of Senior Renal Transplant Recipients on Advagraf
Status: NOT_YET_RECRUITING
Conditions: Graft Failure|Death|Acute Rejection of Renal Transplant|Infections|Bone Disease|Post Transplant Diabetes Mellitus|Quality of Life|HLA Antibody Production|Cardiovascular Risk Factors|Non-HLA Antibody Production
Interventions: DRUG: Tacrolimus once daily (Advagraf)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clip-assisted Fixation to Prevent Migration of Fully Covered Self-expandable Metal Stent in Patients Undergoing ERCP
Status: COMPLETED
Conditions: Pancreaticobiilary Diseases|Endoscopic Retrograde Cholangiopancreatography
Interventions: DEVICE: FCSEMS plus Clip|DEVICE: FCSEMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Alisertib (MLN8237) in Combination With Weekly Paclitaxel in East Asian Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Advanced Solid Tumors|Ovarian Cancer|Small Cell Lung Cancer
Interventions: DRUG: Alisertib|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 0/1 Biomarker and Pharmacodynamic Study of Roflumilast in Patients With Advanced B-Cell Hematologic Malignancies (CTRC# 13-0013)
Status: COMPLETED
Conditions: Advanced B-cell Lymphoid Malignancies
Interventions: DRUG: Prednisone|DRUG: Roflumilast
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preeclamptic Patients and Pentraxin 3 & Lipoprotein-associated Phospholipase A2
Status: COMPLETED
Conditions: Pre-Eclampsia
Interventions: DIAGNOSTIC_TEST: Pentraxin 3 ; new biomarker|DIAGNOSTIC_TEST: Lipoprotein-associated phospholipase A2 ; new biomarker
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Estimate the Effects of Inhaled Versus Intravenous (IV) Infusion of Human Insulin in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Exubera
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of RO7293583 in Participants With Unresectable Metastatic Tyrosinase Related Protein 1 (TYRP1)-Positive Melanomas
Status: COMPLETED
Conditions: Cutaneous Melanoma|Uveal Melanoma|Mucosal Melanoma
Interventions: DRUG: RO7293583|DRUG: Tocilizumab|DRUG: Obinutuzumab|DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ubiquinone (Coenzyme Q10) Application After Gingival Recession Coverage
Status: COMPLETED
Conditions: Gingival Recession
Interventions: OTHER: Gingival recession coverage|DRUG: with CoQ10 spray application|DRUG: with placebo spray application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Pulse Stimulation (TPS) in Post-COVID-19
Status: RECRUITING
Conditions: Post-COVID-19 Syndrome|Fatigue
Interventions: DEVICE: Transcranial pulse stimulation Verum|DEVICE: Transcranial pulse stimulation Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Hydrocortisone in Treatment of Severe Sepsis/Septic Shock Patients With Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
Status: COMPLETED
Conditions: Septic Shock|Severe Sepsis|Acute Lung Injury|Acute Respiratory Distress Syndrome
Interventions: DRUG: Placebo|DRUG: Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of p38 Kinase Inhibitor to Treat Patients With Atherosclerosis
Status: COMPLETED
Conditions: Vascular Diseases
Interventions: OTHER: Placebo|DRUG: BMS-582949|DRUG: Atorvastatin|DRUG: Statin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Thermic Effect of Feeding in Cystic Fibrosis
Status: WITHDRAWN
Conditions: Cystic Fibrosis
Interventions: DIETARY_SUPPLEMENT: Boost VHC|DIETARY_SUPPLEMENT: Ensure High Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Chronic Statin Use During Surgery on Inflammation and Infection Rates
Status: COMPLETED
Conditions: Inflammation|Infection|Endothelial Function
Interventions: DRUG: Atorvastatin|DRUG: Atorvastatin|DRUG: Atorvastatin|DRUG: Atorvastatin|OTHER: Control
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy
Status: UNKNOWN
Conditions: Laryngopharyngeal Reflux|Hypertrophy of Lingual Tonsil
Interventions: DRUG: dexlansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Supplement With Magnesium, Vitamins, Rhodiola and L-theanine Stressed Subjects: Randomized Study Versus Placebo (MAGRITTE)
Status: COMPLETED
Conditions: Stress, Psychological
Interventions: DIETARY_SUPPLEMENT: Stress Resist® (oral dietary supplement)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mobile Internet Healthcare and Three Disciplines Co-management Intervention for Overweight/Obese Prediabetic Patients
Status: RECRUITING
Conditions: Overweight/Obesity|Prediabetes|Weight Management
Interventions: BEHAVIORAL: mobile internet healthcare and "co-management of three disciplines"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Multiple Exercise Trainings in Chronic Respiratory Disease
Status: COMPLETED
Conditions: Chronic Pulmonary Disease
Interventions: DEVICE: Eccentric bike|DEVICE: Helmet ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Consumption of Bagel Without Palm Oil on Postprandial Lipidemia
Status: COMPLETED
Conditions: Hyperlipemia
Interventions: COMBINATION_PRODUCT: Optimized Bagel|COMBINATION_PRODUCT: Conventional Bagel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Closed Suction Drainage and Natural Drainage of the Pancreatic Duct in Pancreaticojejunostomy
Status: COMPLETED
Conditions: Pancreatic Fistula
Interventions: PROCEDURE: closed suction drainage of pancreatic duct|PROCEDURE: natural drainage of pancreatic duct
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Dental Bleaching In-office
Status: COMPLETED
Conditions: Esthetics, Dental
Interventions: OTHER: dental bleaching|PROCEDURE: Gingivoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Augmented Feedback on Lumbar Postural and Movement Control During Physiotherapy and Home Exercise
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DEVICE: Augmented Feedback|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biological Standardization of Blomia Tropicalis Allergen Extract
Status: COMPLETED
Conditions: Allergy to Mites
Interventions: BIOLOGICAL: Four different concentrations of Blomia tropicalis allergen extract, positive control and negative control
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Resveratrol for the Treatment of Non Alcoholic Fatty Liver Disease and Insulin Resistance in Overweight Adolescents
Status: COMPLETED
Conditions: NAFLD|TYPE 2 DIABETES|METABOLIC SYNDROME
Interventions: DIETARY_SUPPLEMENT: Resveratrol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of PEG-Intron Plus REBETOL in Pediatric Subjects With Chronic Hepatitis C (Study P02538 Part 1)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: BIOLOGICAL: peginterferon alfa-2b (PEG2b) (SCH 54031)|DRUG: ribavirin (SCH 18908)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dronabinol After Arthroscopic Surgery
Status: RECRUITING
Conditions: Knee Osteoarthritis|Knee Injuries|Meniscus Tear|Synovitis of Knee|Knee Ligament Injury|Chondral Injury of Left Knee|Chondral Injury of Right Knee|Loose Body Knee
Interventions: DRUG: Dronabinol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Mirtazapine or Clonidine for Post-spinal Anesthesia Shivering
Status: COMPLETED
Conditions: Shivering
Interventions: DRUG: Mirtazapine|DRUG: Clonidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Eye Movement Desensitization & Reprocessing vs Cognitive Behavioral Therapy in Post-Traumatic Stress and Comorbid Disorders in Pakistan
Status: RECRUITING
Conditions: Post Traumatic Stress Disorder|Depression, Anxiety
Interventions: BEHAVIORAL: Eye Movement Desensitization & Reprocessing Therapy|BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Clinical Study to Evaluate the RxSight Light Adjustable Lens With the Light Delivery Device in Subjects With Preoperative Corneal Astigmatism
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: RxSight RxLAL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT