pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Implementing Group Physical Therapy (PT) for Veterans With Knee Osteoarthritis (Group PT): Function QUERI 2.0
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Osteoarthritis
Interventions: OTHER: Implementation Strategy: Foundational REP|OTHER: Implementation Strategy: Enhanced REP (enREP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Pembrolizumab (MK-3475) in Participants With Progressive Locally Advanced or Metastatic Carcinoma, Melanoma, or Non-small Cell Lung Carcinoma (P07990/MK-3475-001/KEYNOTE-001)
Status: COMPLETED
Conditions: Cancer, Solid Tumor
Interventions: BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of DC-806 in Participants With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: DC-806|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Individualized Anti-Cancer Vaccine Study in Patients With HCC
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: AlloVax|BIOLOGICAL: CRCL|BIOLOGICAL: AlloStim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Right Ventricular Lead Position on Defibrillation Threshold
Status: WITHDRAWN
Conditions: Ventricular Tachycardia|Ventricular Fibrillation
Interventions: PROCEDURE: Implantable Cardioverter Defibrillator (ICD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase II Trial of 72-Hour Continuous IV Infusion of 9-Aminocamptothecin With G-CSF Support in Patients With Advanced Ovarian Cancer Previously Treated With Paclitaxel and Cisplatin
Status: COMPLETED
Conditions: Ovarian Neoplasms
Interventions: DRUG: 9-aminocamptothecin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Glaucoma Screening Using Dynamic Analysis of Computerized Pupillary Light Reflex Assessment Device
Status: UNKNOWN
Conditions: Primary Open Angle Glaucoma|Primary Open-Angle Glaucoma, Unspecified Eye|Primary Open Angle Glaucoma of Both Eyes|Suspect Glaucoma|Ocular Hypertension
Interventions: DEVICE: Computerized pupillary light reflex assessment device
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 5-Alpha Reductase 2 as a Marker of Resistance to 5ARI Therapy
Status: RECRUITING
Conditions: Benign Prostatic Hyperplasia|Prostate Hyperplasia|Prostate Disease|Prostate Hypertrophy|Prostate Pain|Lower Urinary Tract Symptoms|Urinary Obstruction|Urinary Tract Disease
Interventions: DRUG: Finasteride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Open Label Trial of 6 Months Versus 12 Months DAPT After Drug-Eluting Stent in STEMI
Status: COMPLETED
Conditions: Myocardial Infarction|Cardiovascular Disease
Interventions: OTHER: 6 months DAPT|OTHER: 12 months DAPT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess the Pharmacokinetics, Safety and Tolerability of Abediterol Administered Once Daily for 9 Days, in Patients With Asthma on Inhaled Corticosteroids
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Abediterol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Determining Optimal Halo Pin Management Practises to Decrease Pin Complications
Status: COMPLETED
Conditions: Unstable Cervical Injury
Interventions: PROCEDURE: Halo pin re-tensioning|PROCEDURE: Placebo Re-tensioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Early Reassessment of Intravenous Antiinfective Therapy Due to "Antiinfective Reminders" (AIR Study)
Status: COMPLETED
Conditions: Infection as Complication of Medical Care
Interventions: OTHER: electronic reminders
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Assess Safety and Improvement in Skin Barrier After Using 2 Facial Sunscreens in Adults With Sensitive Skin
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Sunscreen C Color 2.0 SPF 70|OTHER: Sunscreen C Color 3.0 SPF 70|OTHER: Sunscreen M Very Light SPF 50|OTHER: Sunscreen M Golden Color SPF 50
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Film Modelling in Paediatric Dentistry
Status: COMPLETED
Conditions: Cooperative Behaviour|Dental Anxiety
Interventions: BEHAVIORAL: tell- show- do|BEHAVIORAL: film modelling|DRUG: injection of local anesthesia solution|PROCEDURE: occlusal cavity preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Development and Pilot Trial of an Intervention to Reduce Disclosure Recipients Negative Social Reactions and Victims Psychological Distress and Problem Drinking
Status: COMPLETED
Conditions: Social Skills|Self-Criticism|Post-traumatic Stress Disorder|Depression|Alcohol Abuse|Drinking, College|Alcohol Drinking|Alcohol; Harmful Use|Social Stigma|Social Norms|Social Responsibility|Social Behavior|Empathy|Coping Skills|Coping Behavior
Interventions: BEHAVIORAL: Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Galectin-3 in Serum and Saliva of Pemphigus Patients
Status: NOT_YET_RECRUITING
Conditions: Galectin-3 and Pemphigus
Interventions: DIAGNOSTIC_TEST: Galectin 3 measurement in serum and saliva by ELIZA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of TenoMiR in Lateral Epicondylitis
Status: RECRUITING
Conditions: Tennis Elbow
Interventions: DRUG: TenoMiR|DRUG: 0.9% Sodium Chloride Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COIN: A Pilot Study of Cash Transfers to Improve Outcomes in Low-Income Preterm Neonates and Their Families
Status: COMPLETED
Conditions: Preterm Birth
Interventions: OTHER: Unconditional Cash Transfer (High-Value)|OTHER: Unconditional Cash Transfer (Low-Value)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effects of Canagliflozin (JNJ-28431754) on the Pharmacokinetics, Pharmacodynamics, and Safety of Simvastatin in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Simvastatin|DRUG: Canagliflozin (JNJ-28431754)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Self Selected Population Study of Undiagnosed NAFLD and NASH, Using an Echosens FibroScan, in at Risk Populations
Status: COMPLETED
Conditions: NAFLD|NASH - Nonalcoholic Steatohepatitis|Cirrhosis, Liver|Fatty Liver
Interventions: OTHER: Fibroscan screening
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sulindac in Preventing Lung Cancer in Current or Former Smokers With Bronchial Dysplasia
Status: COMPLETED
Conditions: Precancerous Condition|Stage I Non-small Cell Lung Cancer|Tobacco Use Disorder
Interventions: DRUG: sulindac|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Insulin Detemir in Combination With OADs in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Electrical Acupoint Stimulation(TEAS) for Hypotension After Spinal Anesthesia in Parturients
Status: COMPLETED
Conditions: Hypotension
Interventions: OTHER: TEAS|OTHER: Non-acupoint stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1b/2, Multicenter, Open-label Study of Oprozomib and Dexamethasone in Patients With Relapsed and/or Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Oprozomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relieving Chronic Pain in Older Adults With Transcranial Direct Current Stimulation
Status: RECRUITING
Conditions: Pain, Chronic
Interventions: OTHER: actual transcranial direct current stimulation (tDCS)|OTHER: placebo transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impacts of Low-Dose Dexmedetomidine on Sleep Quality in Mechanically Ventilated ICU Patients
Status: COMPLETED
Conditions: Aged|Postoperative Period|Intensive Care Units|Mechanical Ventilation Complication|Sleep Disorders|Dexmedetomidine
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo (normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vaginal CO2 Laser Therapy for Genitourinary Syndrome in Breast Cancer Survivors
Status: NOT_YET_RECRUITING
Conditions: Genitourinary Syndrome of Menopause
Interventions: DEVICE: SmartXIDE2V2LR, Monalisa Touch, DEKA, Florence, Italy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: EVALUATION OF THE REAL-LIFE CONTRIBUTION OF VISIOCYT® BLADDER CYTOLOGY IN PATIENTS WITH SUSPECTED BLADDER TUMOR OR IN THE FOLLOW-UP OF A BLADDER TUMOR
Status: NOT_YET_RECRUITING
Conditions: Bladder Cancer
Interventions: DIAGNOSTIC_TEST: cytology
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Myocardial Deformation in Real-time 3D Ultrasound. Normal Values in Adults and Validation Against the Tagged MRI
Status: UNKNOWN
Conditions: Myocardial Infarction
Interventions: OTHER: MRI|OTHER: 3D cardiac ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Sequential Combination of FOLFOX and Toripalimab for Perioperative Immuno-Oncology Therapy of HER2-negative Adenocarcinoma of the Esophagogastric Junction (Siewert I/II):
Status: NOT_YET_RECRUITING
Conditions: Gastroesophageal Adenocarcinoma
Interventions: DRUG: toripalimab FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Whole-Body Hypothermia for Neonates With Hypoxic-Ischemic Encephalopathy(HIE)
Status: WITHDRAWN
Conditions: Hypoxic- Ischemic Encephalopathy|Whole-Body Hypothermia|Brain Injury
Interventions: DEVICE: modified Whole-Body Hypothermia|DEVICE: standard Whole-Body Hypothermia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of LY686017 on Alcohol Craving
Status: COMPLETED
Conditions: Alcohol Dependence|Alcoholism
Interventions: DRUG: LY686017|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reappraisal of GIK in Acute STEMI by Pre-hospital Administration
Status: UNKNOWN
Conditions: Myocardial Infarction
Interventions: DRUG: Glucose-Insulin-Potassium|DRUG: Glucose 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mental Health Support for SickKids Children and Families During COVID-19 Using Established eHealth Interventions
Status: ACTIVE_NOT_RECRUITING
Conditions: Anxiety Disorder of Childhood or Adolescence
Interventions: BEHAVIORAL: Virtual-Care Cognitive Behavioural Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Adherence to Anemia Management Policy on Repeat Hospitalization in End Stage Renal Disease (ESRD)
Status: UNKNOWN
Conditions: Anemia|Mortality
Interventions: OTHER: Early anemia diagnosis and treatment|OTHER: No change from normal routine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An All-Comers Observational Study of the MicroStent™ Peripheral Vascular Stent System in Subjects With Peripheral Arterial Disease
Status: UNKNOWN
Conditions: Peripheral Arterial Disease|Peripheral Artery Disease|Critical Limb Ischemia|Critical Lower Limb Ischemia
Interventions: DEVICE: MicroStent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Anticoagulation Regimens in Pregnant Patients With Prosthetic Heart Valves
Status: UNKNOWN
Conditions: Pregnancy|Heart; Complications, Valve, Prosthesis
Interventions: DRUG: Low Molecular Weight Heparine : Enoxaparine|DRUG: Enoxaparine and 2.5 mg Warfarin|DRUG: Enoxaparine and 4mg Warfarin|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Volume Responsiveness By Ultrasound Of Carotid Blood Flow In Patients With Cardiogenic Shock
Status: COMPLETED
Conditions: Cardiogenic Shock|Volume Responsiveness|Ultrasound
Interventions: OTHER: Transthoracic echocardiography and Carotid artery doppler (PHILIPS HD11 XE ultrasound device) before and after PLR test.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Gemcitabine Plus Ascorbate for Sarcoma in Adults (Pilot)
Status: RECRUITING
Conditions: Sarcoma|Soft Tissue Sarcoma|Unresectable Soft Tissue Sarcoma|Metastatic Bone Tumor|Bone Sarcoma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Plinabulin and Pegfilgrastim in People With Multiple Myeloma Undergoing an Autologous Hematopoietic Stem Cell Transplant (AHCT)
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Plinabulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of PSORI-CM01 Formula vs Gu Ben Hua Yu Formula Combined With AD-MSCs in Psoriasis
Status: RECRUITING
Conditions: Traditional Chinese Medicine|Drug Effect|Drug Safety|Psoriasis|Mesenchymal Stromal Cells
Interventions: DRUG: PSORI-CM01 formula|DRUG: Gu Ben Hua Yu formula|BIOLOGICAL: adipose-derived multipotent mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy of IP on Alertness and Mental Fatigue
Status: COMPLETED
Conditions: Mental Fatigue
Interventions: DIETARY_SUPPLEMENT: AG-01|DIETARY_SUPPLEMENT: AG-05|DIETARY_SUPPLEMENT: AG-06|DIETARY_SUPPLEMENT: AG-07
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparative Study of Immunogenicity and Safety of a 2-dose Regimen of ProQuad® Manufactured With rHA (V221-038)
Status: COMPLETED
Conditions: Measles|Mumps|Rubella|Varicella
Interventions: BIOLOGICAL: ProQuad® manufactured with recombinant Human Albumin (rHA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dextenza vs Prednisolone Acetate After Cataract Surgery for Patients With Diabetes
Status: UNKNOWN
Conditions: Cataract Diabetic|Macula Edema
Interventions: DRUG: Dextenza 0.4Mg Ophthalmic Insert|DRUG: Prednisolone Acetate 1% Oph Susp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Diacetylmorphine (DAM) on Brain Function and Stress Response
Status: COMPLETED
Conditions: Opiate
Interventions: DRUG: diacetylmorphine (DAM)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Long Term Study of a Medication for Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: atomoxetine hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Combination Study of MM-151 With MM-121, MM-141, or Trametinib
Status: TERMINATED
Conditions: Colorectal Cancer|Non-small Cell Lung Cancer|Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: MM-151|DRUG: MM-121|DRUG: MM-141|DRUG: trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Difficult Intubation and Tongue Protrusion
Status: COMPLETED
Conditions: Difficult Intubation, Tongue Mobility
Interventions: OTHER: Protrude tongue maximally and upward (PTMU)|OTHER: Protrude tongue maximally and downward (PTMD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Prediction of Reverse Remodeling and Outcome in Patients With Severe Secondary Mitral Valve Regurgitation Undergoing Transcatheter Edge-to-edge Mitral Valve Repair
Status: RECRUITING
Conditions: Severe Mitral Regurgitation
Interventions: DIAGNOSTIC_TEST: Cardiac magnetic resonance imaging before the procedure|PROCEDURE: Transcatheter mitral edge-to-edge repair.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Reversal of Dual Antiplatelet Therapy With Cold Stored Platelets
Status: UNKNOWN
Conditions: Bleeding|Platelet Dysfunction Due to Drugs|Platelet Dysfunction
Interventions: DRUG: Autologous Platelet Transfusion (room-temperature-stored)|DRUG: Autologous Platelet Transfusion (cold-stored 5 days)|DRUG: Autologous Platelet Transfusion (cold-stored 10 days)|DRUG: Autologous Platelet Transfusion (cold-stored 15 days)|DRUG: Aspirin|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder
Interventions: DRUG: Acamprosate calcium|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase I Study of Vorinostat in Combination With Docetaxel in Patients With Advanced and Relapsed Solid Malignancies.
Status: TERMINATED
Conditions: Non-Small-Cell Lung Carcinoma|Prostate Cancer|Bladder Cancer|Urothelial Carcinoma
Interventions: DRUG: vorinostat (suberoylanilide hydroxamic acid)|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HighCycle Study: Effect of Acetazolamide on Acute Mountain Sickness in Women Compared to Men
Status: RECRUITING
Conditions: Acute Mountain Sickness
Interventions: DRUG: Acetazolamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Alemtuzumab and CHOP Chemotherapy for Aggressive Histological Peripheral T-Cell Lymphomas
Status: COMPLETED
Conditions: Peripheral T-cell Lymphomas
Interventions: DRUG: Alemtuzumab (Campath-1H)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STAR Study Investigating Performance and Safety of the Medical Device SiPore15™
Status: COMPLETED
Conditions: PreDiabetes|Pre Diabetes|Prediabetic State|Type2 Diabetes|Type2 Diabetes Mellitus|Overweight|Obese
Interventions: DEVICE: SiPore15™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Withdrawal of Tiratricol Treatment in Males With Monocarboxylate Transporter 8 Deficiency (MCT8 Deficiency)
Status: RECRUITING
Conditions: Monocarboxylate Transporter 8 Deficiency|Allan-Herndon-Dudley Syndrome
Interventions: DRUG: Tiratricol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise and Stress Management Post Autologous and Allogeneic Transplant (BMT CTN 0902)
Status: COMPLETED
Conditions: Physiological Stress
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: Stress Management|BEHAVIORAL: Exercise and Stress Management|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Quetiapine Related Neurochemical Changes as Measured by Magnetic Resonance Spectroscopy in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: quetiapine|OTHER: no intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BL-B01D1 in Patients With Locally Advanced or Metastatic Urological Tumors and Other Solid Tumors
Status: RECRUITING
Conditions: Locally Advanced or Metastatic Urinary Tumors|Other Solid Tumors
Interventions: DRUG: BL-B01D1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concomitant High-resolution Recording of Haemodynamic and Electrical Activities of Children With Typical or Atypical Absence Seizures
Status: UNKNOWN
Conditions: Epilepsy
Interventions: DEVICE: Near Infra Red Spectroscopy (NIRS)|DEVICE: Electroencephalography (EEG)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Shigella Sonnel O-SPC/rBRU Conjugate Vaccine
Status: COMPLETED
Conditions: Immunogenicity|Shigellosis
Interventions: BIOLOGICAL: Shigella Sonnei O-SPC/rBRU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Intrathecal Mg in Gynecologic Laparoscopic Surgeries.
Status: COMPLETED
Conditions: Gynecologic Laparoscopic Surgery
Interventions: DRUG: intrathecal Mg sulfate.|DRUG: intrathecal bupivacaine 15 mg.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET
Status: ACTIVE_NOT_RECRUITING
Conditions: Anaplastic Medulloblastoma|Medulloblastoma
Interventions: DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Cyclophosphamide|BIOLOGICAL: Filgrastim|DRUG: Isotretinoin|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|RADIATION: Radiation Therapy|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MF59-adjuvanted Influenza Vaccine and 23-valent Pneumococcal Polysaccharide Vaccine
Status: COMPLETED
Conditions: Influenza, Human|Pneumococcal Infections
Interventions: BIOLOGICAL: Fluad alone|BIOLOGICAL: Fluad and PPV23 on the different arms|BIOLOGICAL: Fluad and PPV23 on the same arm|BIOLOGICAL: PPV23 alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prazosin for ETOH or Cocaine Craving
Status: TERMINATED
Conditions: Alcoholism|Cocaine Dependence
Interventions: DRUG: Prazosin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Plyometric Exercise on Stability in Professional Indoor Soccer Players: A Pilot Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Plyometric Exercises
Interventions: OTHER: Plyometric exercise|OTHER: Regular exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Use of Carbon Dioxide as a Contrast Media for Performing Endovascular Procedures
Status: UNKNOWN
Conditions: Critical Lower Limb Ischemia|Abdominal Aortic Aneurysms
Interventions: DRUG: CO2|DRUG: Iodine contrast media
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Triple Versus Dual Antiplatelet Therapy After ABT578-Eluting Stent
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: cilostazol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: WalkMORE: A Volunteer-driven Walking Intervention
Status: ACTIVE_NOT_RECRUITING
Conditions: Frailty|Deconditioning|Early Ambulation
Interventions: BEHAVIORAL: WalkMORE group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Self-Directed Exercise Program for Adults With Arthritis
Status: COMPLETED
Conditions: Arthritis|Osteoarthritis|Rheumatoid Arthritis|Fibromyalgia
Interventions: BEHAVIORAL: Multicomponent exercise|BEHAVIORAL: Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 1
Status: RECRUITING
Conditions: Peripheral Vascular Diseases
Interventions: DIETARY_SUPPLEMENT: Antioxidant|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: GLP-1 RAs in Patients With Polycystic Ovary Syndrome (PCOS)
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: GLP-1 RAs|OTHER: calorie restricted diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Tipifarnib in Squamous Head and Neck Cancer With HRAS Mutations
Status: COMPLETED
Conditions: Thyroid Cancer|Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)|HRAS Mutant Tumor|Other Squamous Cell Carcinoma (SCC) With HRAS Mutant Tumor
Interventions: DRUG: Tipifarnib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Dexmedetomidine in Patients Requiring Sedation During Monitored Anesthesia Care (MAC)
Status: COMPLETED
Conditions: Anesthesia|Surgical Procedures, Elective
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pain and Discomfort With Anterior Versus Posterior Builds-up
Status: UNKNOWN
Conditions: Malocclusion|Deep Bite
Interventions: DEVICE: orthodontic - Anterior resin builds-ups|DEVICE: orthodontic - Posterior resin builds-ups
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Equivalence of Fluorouracil Cream, 5% Compared With Fluorouracil 5% Topical Cream of MylanPharmaceuticals Inc., U.S.A in the Treatment of Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratoses
Interventions: DRUG: Test Product (A): Fluorouracil Cream, 5% topical cream|DRUG: Reference Product (B): Fluorouracil 5% Topical Cream of Mylan Pharmaceuticals Inc., Morgantown, WV 26505 U.S.A.|DRUG: Placebo Product (C): Test vehicle cream for fluorouracil 5% of Encube Ethicals Pvt. Ltd., India
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label Safety, Efficacy and Pharmacokinetic Study of a Recombinant FVIII Compared to Recombinant Human Antihemophilic FVIII in Patients With Severe Hemophilia A
Status: COMPLETED
Conditions: Hemophilia A
Interventions: BIOLOGICAL: rVIII-SingleChain|BIOLOGICAL: Octocog alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Randomized Trial of the Combination of Cetuximab and Sorafenib or Single Agent Cetuximab
Status: COMPLETED
Conditions: Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma|Recurrent Metastatic Squamous Neck Cancer With Occult Primary|Recurrent Salivary Gland Cancer|Recurrent Squamous Cell Carcinoma of the Hypopharynx|Recurrent Squamous Cell Carcinoma of the Larynx|Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity|Recurrent Squamous Cell Carcinoma of the Nasopharynx|Recurrent Squamous Cell Carcinoma of the Oropharynx|Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Recurrent Verrucous Carcinoma of the Larynx|Recurrent Verrucous Carcinoma of the Oral Cavity|Salivary Gland Squamous Cell Carcinoma|Stage IV Squamous Cell Carcinoma of the Hypopharynx|Stage IV Squamous Cell Carcinoma of the Nasopharynx|Stage IVA Salivary Gland Cancer|Stage IVA Squamous Cell Carcinoma of the Larynx|Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVA Squamous Cell Carcinoma of the Oropharynx|Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVA Verrucous Carcinoma of the Larynx|Stage IVA Verrucous Carcinoma of the Oral Cavity|Stage IVB Salivary Gland Cancer|Stage IVB Squamous Cell Carcinoma of the Larynx|Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVB Squamous Cell Carcinoma of the Oropharynx|Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVB Verrucous Carcinoma of the Larynx|Stage IVB Verrucous Carcinoma of the Oral Cavity|Stage IVC Salivary Gland Cancer|Stage IVC Squamous Cell Carcinoma of the Larynx|Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVC Squamous Cell Carcinoma of the Oropharynx|Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVC Verrucous Carcinoma of the Larynx|Stage IVC Verrucous Carcinoma of the Oral Cavity|Tongue Cancer|Untreated Metastatic Squamous Neck Cancer With Occult Primary
Interventions: BIOLOGICAL: cetuximab|OTHER: placebo|DRUG: sorafenib tosylate|OTHER: laboratory biomarker analysis|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visual Field Changes in TECNIS ZCB00 Monofocal vs. TECNIS Symfony Extended Depth of Focus Intraocular Lens Implantation
Status: WITHDRAWN
Conditions: Lenses, Intraocular|Visual Fields|Cataract
Interventions: DIAGNOSTIC_TEST: 24-2 SITA Standard Humphrey Visual Field Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Randomized, Single Dose, Two-way Crossover Open-label Study to Determine the Bioequivalence of Gabapentin From Nerpentin 600 mg (Test ) F.C.T (Aman Pharma ,Egypt.) and Gabapentin From Neurontin 300 mg (Referance ) H.G.C. ( Pfizer Egypt)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Gabapentin|DRUG: Neurontin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aging and Reward System Response to Inflammation and Anxiety Study
Status: RECRUITING
Conditions: Anhedonia|Inflammation|Anxiety|Aging|Depression
Interventions: BIOLOGICAL: Endotoxin|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Assessment of Healing Properties Using Hyaluronic Acid Topical Application in Parasymphyseal Fracture Fixation: A Randomized Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Maxillofacial Trauma
Interventions: PROCEDURE: conventional group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treating Stress and Anxiety in Individuals With Alcohol Use Disorder (AUD)
Status: NOT_YET_RECRUITING
Conditions: Anxiety Disorders|Alcohol Use Disorder|Stress, Psychological
Interventions: DEVICE: active heat|DRUG: Active c tactile fiber stimulation|DEVICE: sham heat|DEVICE: Sham c tactile fiber stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Lipodystrophy Syndrome and Its Role as Cause of Metabolic Disturbances
Status: COMPLETED
Conditions: Lipodystrophy|Metabolic Syndrome
Interventions: OTHER: Evaluation of metabolic syndrome|OTHER: Evaluation of changes in fat by DXA while on current therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevalence and Level of Thienopyridine Resistance Seen in a Contemporary Percutaneous Coronary Intervention or Coronary Artery Bypass Graft Population
Status: UNKNOWN
Conditions: Increased Drug Resistance
Interventions: OTHER: Thienopyridine resistance testing|OTHER: Aspirin resistance testing|OTHER: Genetic polymorphism assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of ABT-436 in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ABT-436|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Physical Therapy Intervention in Preterm Infants
Status: COMPLETED
Conditions: Preterm Infant|Physical Therapy|Early Intervention|NICU|Home|Motor Development
Interventions: OTHER: Physical Therapy Early Intervention|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Randomized, Double-blind, Parallel Group Study to Determine the Optimal Dose of HL301 After 7 Days Oral Administration in Acute Bronchitis or Acute Exacerbations of Chronic Bronchitis Patients (HL301: Mixed Extract of Rehmannia Glutinosa, Schisandra and so on)
Status: COMPLETED
Conditions: Acute Bronchitis|Acute Exacerbations of Chronic Bronchitis
Interventions: DRUG: HL301 300mg capsule|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Naproxcinod 375 mg bid|DRUG: Naproxcinod 750 mg bid|DRUG: Naproxen 500 mg bid|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Spark of Duval Intervention
Status: UNKNOWN
Conditions: Teen Pregnancy Prevention
Interventions: BEHAVIORAL: S.P.A.R.K (Speaking to the Potential, Ability and Resilience inside Kids) Teen Pregnancy Prevention and Mentoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial of RAD001/Capecitabine in Refractory Gastric Cancer
Status: COMPLETED
Conditions: Metastatic Gastric Cancer
Interventions: DRUG: Everolimus (RAD001)|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visual and Electromyography Assessments in Response to Train-of-Four Stimulation of the Ulnar Nerve
Status: COMPLETED
Conditions: Residual Neuromuscular Blockade
Interventions: DEVICE: TetraGraph
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Vaccine Therapy With or Without Docetaxel in Treating Patients With Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: recombinant fowlpox-prostate specific antigen vaccine|BIOLOGICAL: recombinant vaccinia prostate-specific antigen vaccine|BIOLOGICAL: recombinant vaccinia-B7.1 vaccine|BIOLOGICAL: sargramostim|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Maintenance Treatment of "ITIVA" in AML Patients
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Maintenance Treatment|Minor Residue Disease|Interferon-α-1b|Interleukin-2|Thalidomide|Venentoclax|Azacitidine
Interventions: DRUG: recombinant human interference'- α- 1b, interleukin-2, thalidomide, Venentoclax and Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Sutimlimab (BIVV009) for the Adult Participants With Cold Agglutinin Disease (CAD) Who Have Completed Phase 3 Studies (CARDINAL or CADENZA) in Japan
Status: COMPLETED
Conditions: Cold Agglutinin Disease
Interventions: DRUG: sutimlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conjugated Linoleic Acid / Leucine Versus Metformin on Visceral Fat in Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Conjugated linoleic acid/Leucine|DRUG: Metformin|DIETARY_SUPPLEMENT: Placebo of ACL/Leucine|OTHER: Placebo of Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Different Imaging Methods in the Diagnosis of Gallbladder Polyps
Status: UNKNOWN
Conditions: Polyp of Gallbladder
Interventions: DEVICE: Abdominal high resolution CT|DEVICE: Contrast-enhanced ultrasonography (CEUS)|PROCEDURE: Cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Oral & Faecal Microbiota Analysis in Patients With Rectal Cancer Requiring Pre-operative Therapy Before Surgery, & Correlation With Response
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DIAGNOSTIC_TEST: 16srRNA pyrosequencing analysis of microbiota of saliva and faeces
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Quantification of Dopamine Active Transporter (DAT) in Humans: Validation of a New Radiophamaceutical, the [18F] LBT-999
Status: TERMINATED
Conditions: Idiopathic Parkinson Disease
Interventions: DRUG: [18F] LBT-999 PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Safety, Tolerability, PK, and PD Properties of PRX-115 in Adult Volunteers With Elevated Uric Acid Levels
Status: RECRUITING
Conditions: Gout
Interventions: DRUG: PRX-115|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers in Patients at Risk of Developing Myelodysplastic Syndrome or Other Disorders and in Healthy Participants
Status: UNKNOWN
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: GENETIC: DNA methylation analysis|GENETIC: RNA analysis|GENETIC: cytogenetic analysis|GENETIC: gene expression analysis|GENETIC: mutation analysis|GENETIC: polymerase chain reaction|GENETIC: protein expression analysis|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of a Violet Visible Light Blocking Intraocular Lens (IOL)
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: modified light transmission intraocular lens|DEVICE: monofocal acrylic intraocular lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Indocyanine Green for Localization of Intra-thoracic Lesions
Status: COMPLETED
Conditions: Pulmonary Nodule, Solitary|Pulmonary Nodule, Multiple
Interventions: DRUG: ICG Intervention|DEVICE: Near Infrared Camera
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Study of cardiovAscular Contrasted Phenotypes in Patients With FamIliaI hypercholesteRolemia
Status: COMPLETED
Conditions: Homozygous Familial Hypercholesterolemia
Interventions: GENETIC: Whole Genome Sequencing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Orelabrutinib Combined With Rituximab and Chemotherapy for Relapsed/Refractory B-Cell Lymphoma Patients With Central Nervous System Involvement
Status: RECRUITING
Conditions: CNS Lymphoma
Interventions: DRUG: Orelabrutinib|DRUG: Rituximab|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation Exploring How Course Modality Influences the Effectiveness of the R3 Academy for Couples
Status: RECRUITING
Conditions: Program Modality
Interventions: OTHER: Livestream Modality (treatment)|OTHER: Live Modality (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Anterior Vaginal Sacrospinofixation With Laparoscopic Promontofixation for the Treatment of Anterior and Apical Genitourinary Prolapse
Status: TERMINATED
Conditions: Prolapse Genital
Interventions: PROCEDURE: promontofixation|PROCEDURE: sacrospinofixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK and PD Within-Subject Variability of a Single Dose of Afrezza Inhaled Technosphere Insulin in Patients With Diabetes Mellitus Type 1 (T1DM)
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Technosphere Insulin SAR439065 Afrezza®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myo-inositol and Melatonin in Pre-menopausal Women
Status: COMPLETED
Conditions: Pre-menopausal Irregular Cycles and Bleedings
Interventions: DIETARY_SUPPLEMENT: melatonin|DIETARY_SUPPLEMENT: myo-inositol|DIETARY_SUPPLEMENT: melatonin plus myo-inositol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Manual Lymphatic Drainage and Kinesiotaping on Lower Extremity Edema
Status: COMPLETED
Conditions: Total Knee Arthroplasty|Edema|Exercise
Interventions: OTHER: Manual Lymphatic Drainage|OTHER: Kinesio Taping|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of AMG 330 in Subjects With Myeloid Malignancies
Status: TERMINATED
Conditions: Relapsed/Refractory AML|Minimal Residual Disease Positive AML|Myelodysplastic Syndrome
Interventions: DRUG: AMG 330
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduction of COVID 19 Transmission to Health Care Professionals
Status: COMPLETED
Conditions: COVID 19
Interventions: DIAGNOSTIC_TEST: Blood group determination|DIAGNOSTIC_TEST: Antibody titration|DIETARY_SUPPLEMENT: Probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION