pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: TGRX-1942 Chinese Phase I for Advanced Solid Tumor and/or Relapsed/Refractory Hematologic Malignancies
Status: NOT_YET_RECRUITING
Conditions: Non Small Cell Lung Cancer|Advanced Solid Tumor|Hematologic Malignancy
Interventions: DRUG: TGRX-1942
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiopulmonary Resuscitation (CPR) Dissemination Study Using Nurses and Volunteers
Status: COMPLETED
Conditions: Cardiovascular Risk Factors|Coronary Disease|Cardiac Arrest
Interventions: OTHER: CPR Training using the Family and Friends CPR Anytime VSI Kit|OTHER: Implementation of an In-Hospital CPR Training Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Closed Incision Negative Pressure Wound Therapy vs. Foam as Post Operative Dressing
Status: TERMINATED
Conditions: Diabetes|Morbid Obesity|Lymphedema|Orthopedic Disorder
Interventions: DEVICE: Avance Solo|OTHER: Optifoam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization of Spleen VCTE Examinations With FibroScan
Status: UNKNOWN
Conditions: Spleen; Fibrosis
Interventions: DEVICE: FibroScan examination (S)|DEVICE: FibroScan examination (M)|DEVICE: FibroScan examination (XL)|DEVICE: FibroScan examination (Standard M)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Methods of Early Detection and Grading Of Diabetic Peripheral Neuropathy (MEDON)
Status: COMPLETED
Conditions: Neuropathy, Diabetic|Neuropathy, Painful
Interventions: DIAGNOSTIC_TEST: Perception Threshold Tracking (PTT)|DIAGNOSTIC_TEST: Axon-flair mediated respons|DIAGNOSTIC_TEST: Heart rate variability|DIAGNOSTIC_TEST: Quantitative Sensory Testing (QST)|DIAGNOSTIC_TEST: Peripheral blood pressure and transcutaneous oxygen tension|DIAGNOSTIC_TEST: Magnetic Resonance Imaging (MRI)|DIAGNOSTIC_TEST: Questionnaires|DIAGNOSTIC_TEST: Corneal Confocal Microscopy /CCM)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Optimizing Electroconvulsive Therapy for Depression
Status: COMPLETED
Conditions: Depression|Depressive Disorder|Bipolar Disorder
Interventions: PROCEDURE: High dosage electroconvulsive therapy|DRUG: Nortriptyline|DRUG: Venlafaxine|DRUG: Lithium|PROCEDURE: Low dosage electroconvulsive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Hemodynamics and Amount of Blood Flowing Through the Kidneys During Liver Transplant by Measuring Some Physiological Substances in Blood and Urines
Status: UNKNOWN
Conditions: Hypovolemia During Liver Transplantation|Renal Hypoperfusion During Liver Transplantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Accuracy of Endoscopic Ultrasound for Detection of Tumors of the Liver
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma|Hepatoma|Cholangiocarcinoma|Liver Metastases
Interventions: PROCEDURE: Endoscopy ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Botulinum Toxin Injections for Oral Neuropathic Pain
Status: COMPLETED
Conditions: Trigeminal Neuropathy, Traumatic
Interventions: DRUG: BOTOX®, Allergan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-dispensing Fitting Study Comparing the Clinical Performance Hydrogel Sphere Design Contact Lenses.
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: filcon IV I (BC 8.6)|DEVICE: filcon IV I (BC 8.7)|DEVICE: ocufilcon D|DEVICE: methafilcon A (BC 8.6)|DEVICE: methafilcon A (BC 8.7)|DEVICE: somofilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Feasibility to Use Wearable Devices to Collect Physiologic Data During Night Shifts - A Pilot Study
Status: UNKNOWN
Conditions: Sleep Deprivation|Stress
Interventions: DEVICE: Fitbit® Charge HR smart watch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Efficacy of CHF1535 Via NEXT DPI Versus pMDI and BDP DPI100µg on PeakExpiratoryFlow in Asthmatic Patients
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: CHF 1535 100/6 NEXT DPI® 2 months|DRUG: CHF 1535 100/6 pMDI 2 months|DRUG: BDP DPI 2 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of SGN-40 in Patients With Relapsed Diffuse Large B-Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Large B-Cell, Diffuse|Lymphoma, Non-Hodgkin
Interventions: DRUG: SGN-40
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Naltrexone and Varenicline: Weight Gain and Tolerability in Cigarette Smokers
Status: COMPLETED
Conditions: Smoking|Nicotine Dependence
Interventions: DRUG: Naltrexone|DRUG: Varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 3-dimensional Versus 2-dimensional Laparoscopy for Myomectomy
Status: UNKNOWN
Conditions: Laparoscopy
Interventions: PROCEDURE: 3D laparoscope|PROCEDURE: 2D laparoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Subcutaneous Mircera for the Treatment of Anemia in Peritoneal Dialysis Patients.
Status: TERMINATED
Conditions: Anemia
Interventions: DRUG: Epoetin alfa|DRUG: methoxy polyethylene glycol-epoetin beta [Mircera]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fertility and Ovarian Reserve Function in the Patient With Inflammatory Bowel Disease
Status: UNKNOWN
Conditions: Fertility Disorders|Ovarian Reserve Function|Pregnancy Outcomes
Interventions: OTHER: Anti Mueller hormone|OTHER: Estrogen|OTHER: Follicle-Stimulating Hormone|OTHER: Antral alveolar cell count
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Alloantibodies in Pediatric Heart Transplantation
Status: TERMINATED
Conditions: Pediatric Heart Transplantation|Pediatric Heart Transplant Recipients
Interventions: DRUG: Induction Therapy|DRUG: Tacrolimus|DRUG: Mycophenolate Mofetil|PROCEDURE: Intraoperative plasma exchange/pheresis|PROCEDURE: Short-term post-operative plasmapheresis|DRUG: Immunoglobulins, Intravenous|DRUG: Prednisone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study in Healthy Men to Test if Taking Different Formulations of BI 1358894 With or Without Food Influences the Amount of BI 1358894 in the Blood
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1358894 (B)|DRUG: BI 1358894 (C)|DRUG: BI 1358894 (D)|DRUG: BI 1358894 (E)|DRUG: BI 1358894 (A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estrogen Sensitivity and Ovulatory Dysfunction in Obesity
Status: COMPLETED
Conditions: Obesity|Infertility
Interventions: DRUG: Estradiol|DRUG: Gonadotropin-releasing hormone (GnRH)|DRUG: Progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Uptake and Utilization of Amino Acids by Splanchnic Bed
Status: COMPLETED
Conditions: Healthy Males
Interventions: OTHER: Threonine Experimental: Study Period 1|OTHER: Lysine Experimental: Study Period 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Romidepsin and Lenalidomide in Treating Patients With Previously Untreated Peripheral T-Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Hepatosplenic T-cell Lymphoma|Peripheral T-cell Lymphoma|Stage I Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IA Mycosis Fungoides/Sezary Syndrome|Stage IB Mycosis Fungoides/Sezary Syndrome|Stage II Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IIA Mycosis Fungoides/Sezary Syndrome|Stage IIB Mycosis Fungoides/Sezary Syndrome|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IIIA Mycosis Fungoides/Sezary Syndrome|Stage IIIB Mycosis Fungoides/Sezary Syndrome|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IVA Mycosis Fungoides/Sezary Syndrome|Stage IVB Mycosis Fungoides/Sezary Syndrome
Interventions: DRUG: romidepsin|DRUG: lenalidomide|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of Change in Reflux Disease After Sleeve Gastrectomy by Intraluminal Impedance and pH-meter
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease|Obesity, Morbid
Interventions: PROCEDURE: laparoscopic sleeve gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Trial to Learn More About Repeated Monthly Injections of Lu AG09222 in Participants With Allergies to Grass Pollen
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Lu AG09222|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Omega 7 + 3 Combination and Systemic Inflammation
Status: COMPLETED
Conditions: Inflammation
Interventions: DIETARY_SUPPLEMENT: Omega 7 + 3|DIETARY_SUPPLEMENT: Omega 3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Multicenter Comparative Study to Confirm Safety and Effectiveness of the F(ab)2 Antivenom Anavip.
Status: COMPLETED
Conditions: Snake Bite
Interventions: BIOLOGICAL: Crotalinae (pit viper) equine immune F(ab)2|BIOLOGICAL: Crotalinae (pit viper) equine immune F(ab)2|BIOLOGICAL: Crotalidae Polyvalent Immune Fab, ovine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intermittent Bolus vs Continuous Infusion Via ESP Catheters RCT
Status: RECRUITING
Conditions: Post Operative Pain
Interventions: DRUG: Continuous Infusion of ropivacaine|DRUG: Intermittent bolus of ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of MDT-637 in Healthy Volunteers
Status: COMPLETED
Conditions: Drug Safety|Respiratory Syncytial Virus Infections
Interventions: DRUG: MDT-637
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypoallergenic and Anti-inflammatory Feeds in Malawian Children With Severe Acute Malnutrition (SAM)
Status: COMPLETED
Conditions: Severe Malnutrition|Enteritis
Interventions: DIETARY_SUPPLEMENT: Polymeric formula|DIETARY_SUPPLEMENT: Elemental formula|OTHER: Standard management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Anti-CD38 CAR-T in Relapsed or Refractory Multiple Myeloma Patients
Status: COMPLETED
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: BIOLOGICAL: CAR2 Anti-CD38 A2 CAR-T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of a Bioelectric Dressing Used With Negative Pressure Wound Therapy to Treat Diabetic and Pressure Ulcers
Status: COMPLETED
Conditions: Wound Healing
Interventions: DEVICE: Procellera™ Wound Dressing with V.A.C.® Therapy|DEVICE: V.A.C.® Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Nano-Pso Therapy in Menopause
Status: RECRUITING
Conditions: Menopause|Vasomotor; Syndrome
Interventions: DIETARY_SUPPLEMENT: NANO-PSO|OTHER: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Benegut® on Immediate GI Discomfort Relief Caused by Acute Overfeeding in Healthy Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Perilla frutescens extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Assessing MTD, Safety, Tolerability, PK and Anti-tumor Effects of LNS8801alone and With Pembrolizumab
Status: RECRUITING
Conditions: Solid Tumor, Adult
Interventions: DRUG: LNS8801 -Small molecule, orally bioavailable, selective agonist of GPER|BIOLOGICAL: Pembrolizumab - anti-PD-1 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adavosertib With or Without Olaparib in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
Status: RECRUITING
Conditions: Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma
Interventions: DRUG: Adavosertib|DRUG: Olaparib|DRUG: Ceralasertib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Acupuncture for Postpartum Weight Retention
Status: COMPLETED
Conditions: Postpartum Weight Retention
Interventions: PROCEDURE: laser acupuncture|PROCEDURE: sham laser acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcultural Validation of the Physical Activity Scale for Individuals With Physical Disabilities (PASIPD) in French: The PASIPD-Fr
Status: COMPLETED
Conditions: Physical Disability|Neurological Diseases or Conditions
Interventions: BEHAVIORAL: PASIPD-Fr
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Photobiomodulation on Pain During Orthodontic Treatment.
Status: RECRUITING
Conditions: Malocclusion|Orthodontic Treatment
Interventions: DEVICE: PBM Ortho
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Restorative Treatment of Severe Tooth Wear; Direct vs Indirect
Status: COMPLETED
Conditions: Tooth Wear|Dental Restoration Failure|Dental Restoration Wear
Interventions: PROCEDURE: Rehabilitation of severely worn dentitions using minimally invasive composite restorations (Estenia C&B or Clearfil AP-X, Kuraray, Osaka, Japan)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dasatinib for Modulating Immune System After Autologous Stem Cell Transplants for Multiple Myeloma, Non-Hodgkin, or Hodgkin Lymphoma
Status: TERMINATED
Conditions: Non-Hodgkin's Lymphoma|Multiple|Mycosis Fungoides|Hodgkin's Lymphoma|Multiple Myeloma
Interventions: DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abdominal Wall Closure With Triclosan-coated Suture (TCS09-10)
Status: UNKNOWN
Conditions: Wound Infection
Interventions: PROCEDURE: abdominal wall closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Drug-Interaction Study to Evaluate the Effect of Rifampin, a Potent CYP3A4 Inducer, on the Systemic Exposure of Pacritinib in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Pacritinib|DRUG: Rifampin|DRUG: Pacritinib and Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Air Purifiers in Classrooms for Infection Control - a Pilot Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Feasibility|Acceptability
Interventions: DEVICE: Ceiling-Mounted Air Purifiers|DEVICE: Portable Air Purifiers|DEVICE: Portable or Ceiling Mounted Air Purifiers
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Idarubicin, Cytarabine, and Gemtuzumab Ozogamicin in Treating Patients With Previously Untreated High-Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia Secondary to Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: busulfan|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: gemtuzumab ozogamicin|DRUG: idarubicin|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: QuantifyHER: Quantitative Immunofluorescence and/or RT-qPCR for Measuring HER2 in HER2-low Metastatic Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: HER2-positive Metastatic Breast Cancer
Interventions: DIAGNOSTIC_TEST: CE-10-IVD
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Emotion on Episodic Memory in Typically Developing Children and Children With Williams-Beuren Syndrome
Status: COMPLETED
Conditions: Mental Disorders
Interventions: BEHAVIORAL: Manipulation of valence and modality|BEHAVIORAL: Spatial and recognition memory|BEHAVIORAL: Source and content memory
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Qualitative Radionuclide Shuntography for Adult Patients With Suspected V-P Shunt Malfunction
Status: COMPLETED
Conditions: Ventriculoperitoneal Shunt Malfunction|Radionuclide Shuntography
Interventions: PROCEDURE: radionuclide shuntography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Outcomes of Motion-preserving Surgery and Arthrodesis at the Distal Interphalangeal (DIP) Joint
Status: COMPLETED
Conditions: Distal Interphalangeal Arthroplasty|Distal Interphalangeal Arthrodesis
Interventions: DEVICE: DIP arthroplasty or arthrodesis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Children, Known or Suspected to be Caused by Susceptible Gram-positive Organisms, Including MRSA
Status: COMPLETED
Conditions: Methicillin-Resistant Staphylococcus Aureus|Bacterial Infections|Staphylococcal Skin Infections
Interventions: DRUG: Dalbavancin single dose|DRUG: Dalbavancin two dose|DRUG: Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Priming the Epileptic Brain: tVNS to Improve Efficacy of add-on AED in Patients With Focal Epilepsy
Status: UNKNOWN
Conditions: Focal Epilepsy
Interventions: DEVICE: TVNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: This Study Tests How Different Doses of BI 690517 Are Taken up in the Body of Healthy Men. The Study Also Looks at How Food Influences the Amount of BI 690517 in the Blood
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 690517|DRUG: Placebo|DRUG: BI 690517 (Reference)|DRUG: BI 690517
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Group-based Life Skills and Health Empowerment for Married Women to Avoid Unintended Pregnancies in India
Status: RECRUITING
Conditions: Pregnancy, Unplanned|Contraceptive Behavior
Interventions: BEHAVIORAL: TARANG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Non-invasive Ventilation With Helium-oxygen Mixture in Premature Infants With Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Respiratory Distress Syndrome|Premature Infants
Interventions: DRUG: heliox
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Exploratory Study of KPI-121 Effect on Intra- or Subretinal Fluid Due to Retinal Vein Occlusion/Diabetic Macular Edema
Status: COMPLETED
Conditions: Retinal Vein Occlusion|Diabetic Macular Edema
Interventions: DRUG: KPI-121 0.25% Ophthalmic Suspension|DRUG: KPI-121 1.0% Ophthalmic Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Light Emitting Diode-Red Light (LED-RL) Phototherapy for Skin Scarring Prevention
Status: COMPLETED
Conditions: Fibrosis|Skin Scarring|Skin Wound|Hypertrophic Scar|Scar|Keloid
Interventions: DEVICE: LED-RL phototherapy|DEVICE: Mock irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Different Doses of Sevoflurane During Induction of Anesthesia on Emergence Delirium in Children
Status: UNKNOWN
Conditions: Delirium
Interventions: OTHER: Sevoflurane 8%|OTHER: Sevoflurane 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Long Term Evaluation of Safety and Efficacy of Tildrakizumab in Patients With Psoriatic Arthritis
Status: RECRUITING
Conditions: Psoriatic Arthritis
Interventions: DRUG: TILD sub-cutaneous (SC) injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychodynamic Internet Treatment Versus Cognitive Behavioral Therapy (CBT) for Generalized Anxiety Disorder
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: BEHAVIORAL: iCBT|BEHAVIORAL: iPDT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Ginkgo Biloba Extract in the Treatment of Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer's
Interventions: DRUG: Ginkgo biloba dispersible tablets|DRUG: Donepezil|DRUG: Ginkgo biloba dispersible tablets and Donepezil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ethnicity on Changes in VO2max and Cardiac Output in Response to Short-Term High Intensity Interval Training
Status: COMPLETED
Conditions: Improved VO2max and Cardiac Output in Response to Training
Interventions: OTHER: High intensity interval training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Reduce Immunosuppression With Atmp in NS ChildrEn
Status: COMPLETED
Conditions: Nephrotic Syndrome in Children|Steroid-Dependent Nephrotic Syndrome|Idiopathic Nephrotic Syndrome
Interventions: OTHER: Cord-blood mesenchymal stromal cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Betamethasone Versus Triamcinolone Injection in Management of Thyroid Eye Disease
Status: COMPLETED
Conditions: Thyroid Eye Disease
Interventions: PROCEDURE: peri-levator betamethasone injection|PROCEDURE: peri-levator triamcinolone injection|PROCEDURE: peri-levator and retrobulbar betamethasone injection|PROCEDURE: peri-levator and retrobulbar triamcinolone injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Control Alone Versus Dietary Control Plus Use of Proton Pump Inhibitors to Treat Pediatric Hoarseness
Status: TERMINATED
Conditions: Dysphonia
Interventions: DRUG: Lansoprazole|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Exploratory Clinical Trials on the Primary Safety and Effectiveness of High Myopic Posterior Scleral Fixation System
Status: UNKNOWN
Conditions: High Myopia|Macular Schisis
Interventions: DEVICE: High Myopic Posterior Scleral Fixation System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of WRSS1, a Shigella Sonnei Vaccine Candidate
Status: COMPLETED
Conditions: Dysentery|Shigella|Diarrhea
Interventions: BIOLOGICAL: Part 1/Arm 1 of Study: WRSS1 vaccine|BIOLOGICAL: Part 1/Arm 2 of Study: Placebo vaccine|BIOLOGICAL: Part 2/Arm 1 of Study: S. sonnei 53G|BIOLOGICAL: Part 2/Arm 2 of Study: S. sonnei 53G
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of TAK-079 in Combination With Standard Background Therapy in Participants With Moderate to Severe Systemic Lupus Erythematosus (SLE)
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus|Lupus Erythematosus, Systemic
Interventions: DRUG: TAK-079|DRUG: TAK-079 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Phase 3 Study of Oral Ibrexafungerp (SCY-078) Vs. Placebo in Subjects With Recurrent Vulvovaginal Candidiasis (VVC)
Status: COMPLETED
Conditions: Recurrent Vulvovaginal Candidiasis
Interventions: DRUG: Fluconazole Tablet|DRUG: IBREXAFUNGERP|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vitamin D/Calcium Polyp Prevention Study
Status: COMPLETED
Conditions: Colorectal Cancer|Polyps|Adenomas
Interventions: DRUG: Calcium Carbonate|DRUG: Vitamin D3|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Implication of Fluid Strategies Upon Hepatic Outcome in Hepatobiliary Surgery
Status: UNKNOWN
Conditions: Hepatic Complication
Interventions: DRUG: Conservative fluid strategy: 12 mL/kg/h of Lactated Ringer (LR).&Restrictive fluid strategy:6 mL/kg/h of Lactated Ringer (LR).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: AntiCoagulants and COGnition
Status: UNKNOWN
Conditions: Nonvalvular Atrial Fibrillation
Interventions: DRUG: Rivaroxaban 20 MG|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Coronary Images Used During Patient Education on Coronary Artery Disease and Subsequent Lifestyle Modifications. Is a Picture Really Worth a Thousand Words?
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: BEHAVIORAL: Impact of Coronary Images Used During Patient Education on Coronary Artery Disease and Subsequent Lifestyle Modifications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: "THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"
Status: COMPLETED
Conditions: Headache|Intranasal Ketamine
Interventions: DRUG: Ketamine|DRUG: Normal saline|DRUG: Metoclopramide|DRUG: Ketorolac|DRUG: Dexamethasone|DRUG: Benadryl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combination of RC48 and Tislelizumab for Renal Preservation in High-risk UTUC Patients
Status: RECRUITING
Conditions: Upper Urinary Tract Urothelial Carcinoma|Kidney Preservation|HER-2 ADC|PD-1antibody
Interventions: DRUG: RC48 Combined With Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Tolerability of Zoledronic Acid in Patients With Metastatic Prostate Cancer Who Can be Treated With a Group of Medications Known as Bisphosphonates
Status: COMPLETED
Conditions: Prostate Cancer With at Least One Bone Lesion in Patients Receiving Hormonal Therapy and Treatment With Bisphosphonates is Indicated
Interventions: DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Screening At-risk Populations for Hepatic Fibrosis With Non-invasive Markers
Status: RECRUITING
Conditions: Liver Diseases, Alcoholic|Fibrosis
Interventions: DIAGNOSTIC_TEST: transient elastography|DIAGNOSTIC_TEST: Enhanced liver fibrosis test|DIAGNOSTIC_TEST: Indirect serum markers of liver fibrosis|DIAGNOSTIC_TEST: Direct serum markers of liver fibrosis|DIAGNOSTIC_TEST: LiverTRAIL|DIAGNOSTIC_TEST: Cytokeratin 18|DIAGNOSTIC_TEST: Omics markers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Interferon Alfa and Thalidomide in Treating Patients With Soft Tissue Sarcoma or Bone Sarcoma
Status: UNKNOWN
Conditions: Sarcoma
Interventions: BIOLOGICAL: recombinant interferon alfa|DRUG: thalidomide|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Probucol in Patients With Diabetic Nephropathy
Status: COMPLETED
Conditions: Diabetic Nephropathy
Interventions: DRUG: Probucol 250mg/day|DRUG: Probucol 500mg/day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Patient-centered Continuous and Interdisciplinary Shared Decision Making Approach for Breast Cancer Rehabilitation
Status: UNKNOWN
Conditions: Shared Decision Making|Self-Efficacy for Decision Making
Interventions: OTHER: Shared decision making support tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Double-blind, Randomized, Placebo-controlled Study of the Safety, Tolerability and Pharmacokinetics of Ascending Doses of XC243 After Single and Multiple Oral Administration in Healthy Volunteers.
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: XC243 50 mg single|DRUG: XC243 100 mg single|DRUG: Placebo single|DRUG: XC243 200 mg single-dose food effect|DRUG: Placebo single-dose food effect|DRUG: XC243 200 mg multiple|DRUG: Placebo multiple
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Azole-echinocandin Combination Therapy for Invasive Aspergillosis
Status: TERMINATED
Conditions: Invasive Aspergillosis
Interventions: DRUG: Azole|DRUG: Anidulafungin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Effect of Ketoconazole on the Pharmacokinetics of GDC-0980
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: GDC-0980|DRUG: Ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Physical Activity Interventions in Individuals With Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Aquatic Exercise Program|BEHAVIORAL: Stretching Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Increasing Healthcare Engagement Via Routine Vaccination Among Young Black Men Who Have Sex With Men
Status: WITHDRAWN
Conditions: Meningitis|HPV - Anogenital Human Papilloma Virus Infection|Hepatitis A
Interventions: BEHAVIORAL: POL arm|BEHAVIORAL: Comparison arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of AXA1665 in Cirrhotic Subjects With Prior Overt Hepatic Encephalopathy
Status: TERMINATED
Conditions: Hepatic Encephalopathy
Interventions: DRUG: AXA1665|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Cyanoacrylate Obliteration vs. Nadolol Treatment in the Prevention of Gastric Variceal Rebleeding
Status: UNKNOWN
Conditions: Liver Cirrhosis and Hepatoma.|Gastric Variceal Bleeding
Interventions: DRUG: Nadolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Physiotherapist Led Triage in Primary Care for Patients With Hip or Knee OA
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis, Knee|Osteoarthritis, Hip
Interventions: OTHER: Physiotherapist consultation|OTHER: Orthopaedic surgeon consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of the EpiVacCorona Vaccine With the Involvement of Volunteers Aged 60 Years and Above
Status: COMPLETED
Conditions: Covid19
Interventions: BIOLOGICAL: EpiVacCorona (EpiVacCorona vaccine based on peptide antigens for the prevention of COVID-19)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Nepeta Menthoides Extract on Anxiety of Patients With Depression: a Double-blind Randomized Controlled Clinical Trial
Status: COMPLETED
Conditions: Depression|Anxiety
Interventions: DRUG: Nepeta menthoides Boiss & Bohse freeze dried extract|DRUG: Sertraline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy and Safety of Specific Immunotherapy With Modified Allergen Extracts of House Dust Mites
Status: UNKNOWN
Conditions: Allergic Rhinitis
Interventions: BIOLOGICAL: modified allergen extract of house dust mites|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Thalidomide in Treating Patients With Asymptomatic, Indolent Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: DRUG: thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Additional Effect of Intrapulmonary Percussive Ventilation (IPV) on Respiration in People With Multiple Sclerosis (MS).
Status: TERMINATED
Conditions: Multiple Sclerosis
Interventions: DEVICE: Intrapulmonary percussive ventilation (IPV)|BEHAVIORAL: Active breathing training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label Extended Clinical Protocol of Ranibizumab to Evaluate Safety and Efficacy in Rare VEGF Driven Ocular Diseases.
Status: COMPLETED
Conditions: Choroidal Neovascularization|Macular Edema|Glaucoma, Neovascular|Diabetic Retinopathy
Interventions: DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Utility of the Skin Cancer Quality of Life Impact Tool
Status: COMPLETED
Conditions: Skin Neoplasm|Squamous Cell Carcinoma|Basal Cell Carcinoma
Interventions: OTHER: SCQOLIT questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intravenous Isosorbide Dinitrate Versus Sublingual Isosorbide Dinitrate for the Relief of Acute Anginal Episodes in Acute Coronary Syndrome (ACS) Patients
Status: WITHDRAWN
Conditions: Unstable Angina|Myocardial Infarction
Interventions: DRUG: iso sorbide dinitrate iv bolus or s/l
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Maternal Vitamin D for Acute Respiratory Infections in Infancy
Status: COMPLETED
Conditions: Upper Respiratory Tract Infections|Lower Respiratory Tract Infections
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Study of CTA018 Injection to Treat Stage 5 Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease|Secondary Hyperparathyroidism|Chronic Renal Insufficiency|Chronic Renal Failure
Interventions: DRUG: CTA018 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Obstructive Pulmonary Disease (COPD) Outpatient on Demand Clinic
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: on demand clinic|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: celecoxib|DRUG: Ibuprofen|DRUG: Naproxen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of 24-hour Intragastric pH Profiles of Esomeprazole 40 mg and Lansoprazole 30 mg in Healthy Volunteer Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Nexium|DRUG: Prevacid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Neuradiab® Combined With Bevacizumab (Avastin) Therapy in Patients With Recurrent Glioblastoma Multiforme
Status: UNKNOWN
Conditions: Brain Tumors
Interventions: DRUG: Neuradiab in combination with Bevacizumab (Avastin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: B-Cell Hematologic Malignancy Vaccination Registry
Status: WITHDRAWN
Conditions: Monoclonal Gammopathy of Undetermined Significance|Multiple Myeloma|Waldenstrom Macroglobulinemia|Lymphocytosis|Lymphoma, Non-Hodgkin|B-Cell Chronic Lymphocytic Leukemia|Hematological Malignancies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Therapy of Oral Appliance for Adults Jordanians With Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Mild Obstructive Sleep Apnea
Interventions: DEVICE: biomimetic oral appliance therapy (BOAT)|DEVICE: Standard hospital treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Melatonin in the Pretreatment of Organ Donor and the Influence in the Evolution of Liver Transplant.
Status: UNKNOWN
Conditions: Evidence of Liver Transplantation
Interventions: DRUG: Melatonin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Automated Closed Loop Propofol Anaesthesia Versus Desflurane Inhalation Anaesthesia In Bariatric Surgery
Status: COMPLETED
Conditions: Anesthesia; Bariatric Surgery
Interventions: DRUG: Propofol|DRUG: Desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Methadone in Neuropathic Pain
Status: TERMINATED
Conditions: Chronic Neuropathic Pain
Interventions: DRUG: Methadone|DRUG: Controlled Release Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ALK/ROS1/MET Mutations on Plasma ctDNA in Patients With NSCLC
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer Stage III|Non-Small-Cell Lung Cancer Metastatic|Adenocarcinoma of Lung|EGFR Wildtype
Interventions: GENETIC: ctDNA analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CRISOL Contigo: a Multi-level Intervention to Reduce the Disproportionate Toll of COVID-19 Among Latino Communities in Philadelphia.
Status: COMPLETED
Conditions: Covid19|Mental Health Issue|Violence
Interventions: OTHER: Community popular opinion leader (POL) based intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparative Bioavailability Study of 600mg Azithromycin Monohydrate Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Infection
Interventions: DRUG: Azithromycin Monohydrate 600mg Tablets Geneva Pharmaceuticals|DRUG: Zithromax (Azithromycin Dihydrate) 600mg Tablets Pfizer Inc.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of D-cycloserine on Treatment of Posttraumatic Stress Disorder (PTSD) in Youth
Status: COMPLETED
Conditions: Posttraumatic Stress Disorders|PTSD
Interventions: DRUG: D-cycloserine|DRUG: Placebo pill|BEHAVIORAL: CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pelvic Floor Support After Laparoscopic Hysterectomy for Benign Conditions: A Randomized Controlled Trial Comparing Vaginal Cuff Closure Techniques
Status: UNKNOWN
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: Laparoscopic - Vaginal Cuff Closure|PROCEDURE: Vaginal- Vaginal Cuff Closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The PIONEER-01 Study of the Imagio Breast Imaging System
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DEVICE: Imagio OA/US (US and OA/US)|DEVICE: Imagio gray scale ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: TIP (Paclitaxel + Ifosfamide + Cisplatin) Combined With Nimotuzumab & Triprilimab as Neoadjuvant Treatment in Locally Advanced Penile Cancer
Status: COMPLETED
Conditions: Penile Cancer
Interventions: DRUG: Albumin-Bound Paclitaxel|DRUG: Ifosfamide|DRUG: Cisplatin|DRUG: Nimotuzumab|DRUG: Triprilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Bimekizumab on Gene Expression Biomarkers in Study Participants With Moderate to Severe Plaque Psoriasis
Status: NOT_YET_RECRUITING
Conditions: Moderate to Severe Plaque Psoriasis|Psoriatic Arthritis
Interventions: DRUG: bimekizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of a Gene Transfer Vector for Children With Late Infantile Neuronal Ceroid Lipofuscinosis
Status: COMPLETED
Conditions: Batten Disease|Late Infantile Neuronal Ceroid Lipofuscinosis
Interventions: BIOLOGICAL: AAV2CUhCLN2 (3x10^12 particle units)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT