pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Comparison of LASIK Outcomes Using Two Femtosecond Lasers
Status: COMPLETED
Conditions: Myopia|Astigmatism
Interventions: DEVICE: Intralase IFS150|DEVICE: Visumax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Integrating SBRT With Targeted Therapy in Stage IV Oncogene-driven NSCLC
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer Metastatic|Targetable Oncogenes (EGFR, ALK, ROS1)
Interventions: RADIATION: SBRT with protons or photons
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab in Interstitial Pneumonitis
Status: COMPLETED
Conditions: Lung Diseases, Interstitial|Pneumonitis, Interstitial
Interventions: DRUG: Rituximab|RADIATION: Zr-89-rituximab immuno PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Malaria With Dihydroartemisinine + Piperaquine for Forest Rangers
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Arterakine (DHA/piperaquine)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intermittent Versus Continuous Enteral Nutrition in Mechanically Ventilated Patients in the Medical Intensive Care Unit
Status: ENROLLING_BY_INVITATION
Conditions: Enteral Feeding|Nutrition Disorders
Interventions: DIETARY_SUPPLEMENT: Intermittent feed participant|DIETARY_SUPPLEMENT: Continuous feeds participant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center Clinical Trial To Evaluate Chinese Herbal Medicines in the Treatment of Severe Hand-foot-mouth Disease
Status: UNKNOWN
Conditions: Hand, Foot and Mouth Disease
Interventions: DRUG: Herbal concentrate-granules plus western therapy|DRUG: Reduning Injection plus western therapy|DRUG: Western therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TAS-102 and Oxaliplatin for the Treatment of Refractory Stage IV Colon Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colorectal Carcinoma|Recurrent Colon Carcinoma|Refractory Colorectal Carcinoma|Stage IV Colon Cancer AJCC v7|Stage IVA Colon Cancer AJCC v7|Stage IVB Colon Cancer AJCC v7
Interventions: DRUG: Oxaliplatin|DRUG: Trifluridine and Tipiracil Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Loss in Patients With Anorexia Nervosa
Status: UNKNOWN
Conditions: Patients With Anorexia Nervosa
Interventions: OTHER: clinical parameters description|OTHER: para clinical parameters description|OTHER: hormonal parameters dosing|OTHER: bone modeling markers dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Telerehabilitation & Telecoaching of Parents of Cochlear Implanted Children at Sohag University Hospital
Status: UNKNOWN
Conditions: Cochlear Implantation|Hearing Loss
Interventions: BEHAVIORAL: Telerehabilitation and telecoaching|BEHAVIORAL: Face to Face Language sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Physical Activity Intervention Effects on Executive Function, Physical Activity and Sedentary Behaviour in Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Child Behavior
Interventions: BEHAVIORAL: Activity Breaks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Retention Characteristics of Immediate vs Delayed Retainer Delivery Using 3D Digital Model Analysis
Status: RECRUITING
Conditions: Relapse
Interventions: OTHER: immediate orthodontic retainer delivery|OTHER: delayed orthodontic retainer delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PK and Dose Escalation and Expansion Study of DST-2970
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Abiraterone Acetate|DRUG: Prednisone 5Mg Tab|DRUG: DST-2970 (Abiraterone)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study of Sinus Rhythm Mapping in Pulmonary Vein Isolation Naive Patients With Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DIAGNOSTIC_TEST: AI-enabled ECG score for Atrial Fibrillation (DNN score)|DIAGNOSTIC_TEST: Atrial voltage map in sinus rhythm
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 'Tenofovir Pulse and Peg Interferon Alpha 2b' Therapy in HBeAg-positive Patients With Normal ALT
Status: WITHDRAWN
Conditions: HBV
Interventions: DRUG: Tenofovir + Interferon alpha 2b|DRUG: Tenofovir disoproxil Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Cervical Traction With and Without EMG Biofeedback in Patients With Cervical Radiculopathy
Status: COMPLETED
Conditions: Cervical Radiculopathy
Interventions: OTHER: cervical traction with EMG biofeedback|OTHER: cervical traction and conventional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Profile of OROS Hydromorphone in Healthy Taiwanese Participants With Different Genotypes for the UGT2B7 Gene
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Hydromorphone 16 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Approaches to Treat Multiple Sclerosis-Related Fatigue Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis|Multiple Sclerosis, Relapsing-Remitting
Interventions: BEHAVIORAL: Swank Diet|BEHAVIORAL: Wahls Elimination Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of a Food Supplement With Myo-inositol, N-Acetyl-Cystein, Zinc and Vitamins on Sperm DNA Fragmentation
Status: UNKNOWN
Conditions: Male Infertility
Interventions: DIETARY_SUPPLEMENT: Isitol®|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of Safety and Efficacy of Infliximab (Remicade) in Patients With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|COPD
Interventions: DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: HELIX, a Double-masked Study of SYL1001 in Patients With Moderate to Severe Dry Eye Disease (DED)
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: SYL1001 ophthalmic solution|DRUG: Vehicle opthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of EMG-driven Robot-assisted Therapy for the Distal Upper Limb Motor Function in the Chronic Stroke Patients With Botox Injections
Status: COMPLETED
Conditions: Chronic Stroke|Spasticity as Sequela of Stroke|Robotic Rehabilitation
Interventions: DEVICE: Hand of Hope|DRUG: Botulinum toxin type A injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effectiveness and Safety of LY03003 in Patients With Early Primary PD
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: LY03003(Rotigotine,extended-release microspheres)|DRUG: Placebo,extended-release microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Premedication on Sevoflurane Induction
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Fentanyl and Midazolam|DRUG: NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acetaminophen (Tylenol) for Mood and Memory Changes Associated With Corticosteroid Therapy
Status: COMPLETED
Conditions: Asthma|Rheumatic Disease
Interventions: DRUG: Drug: Acetaminophen, Drug: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subjective Study to Assess the Efficacy of APD125 in Patients With Sleep Maintenance Insomnia
Status: COMPLETED
Conditions: Primary Insomnia
Interventions: DRUG: APD125|DRUG: APD125|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Pivot Breath Sensor: Single-Arm Cohort Study
Status: COMPLETED
Conditions: Smoking Reduction|Smoking Behaviors|Smoking, Tobacco|Smoking Cessation
Interventions: DEVICE: Pivot Breath Sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Head Position for Laryngeal Mask Air Leak and Performance in Paediatric Patients (Neutral, Sniffing and Beyond Sniffing Position)
Status: RECRUITING
Conditions: Airway Management
Interventions: DEVICE: Laryngeal mask insertion|DEVICE: Laryngeal mask insertion|DEVICE: Laryngeal mask insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Ropivacaine and Levobupivacaine in High Thoracic Epidural Anesthesia
Status: COMPLETED
Conditions: Coronary Artery Bypass|Epidural Anesthesia
Interventions: DRUG: Ropivacaine|DRUG: Levobupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thyroid Surgery With the New Harmonic Scalpel or the Electrothermal Bipolar Vessel Sealer
Status: COMPLETED
Conditions: Thyroidectomy
Interventions: DEVICE: harmonic scalpel device (FOCUS)|DEVICE: electrothermal bipolar vessel sealing system (LIGASURE PRECISE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia
Status: COMPLETED
Conditions: Breast Neoplasms|Colonic Neoplasms|Rectal Neoplasms
Interventions: DRUG: Propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Compare Dysport® and Botox® in the Treatment of Cervical Dystonia
Status: COMPLETED
Conditions: Cervical Dystonia
Interventions: DRUG: Dysport® (abobotulinumtoxinA)|DRUG: Botox® (onabotulinumtoxinA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Oral Ketone Ester on Cardiac Function in Patients With COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DIETARY_SUPPLEMENT: D-beta-hydroxybutyrate-(R)-1,3 butanediol monoester|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Melatonin Postoperative Sleep Study in Breast Cancer Patients
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Melatonin|DRUG: Placebo|BEHAVIORAL: Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of AL-60371 Otic Suspension in Pediatric Subjects Following Tympanostomy Tube Surgery
Status: WITHDRAWN
Conditions: Otitis Media
Interventions: DRUG: AL-60371 otic suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Niche Trial: Navigated Inhibitory rTMS to Contralesional Hemisphere Trial
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: NBS-guided rTMS|DEVICE: Sham rTMS|PROCEDURE: Task oriented rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Margetuximab, Retifanlimab, Tebotelimab, and Chemotherapy Phase 2/3 Trial in HER2+ Gastric/GEJ Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Cancer|Gastroesophageal Junction Cancer|HER2-positive Gastric Cancer
Interventions: BIOLOGICAL: margetuximab|BIOLOGICAL: Retifanlimab|BIOLOGICAL: Tebotelimab|BIOLOGICAL: Trastuzumab|OTHER: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HORIZON Prospective Clinical Investigation
Status: TERMINATED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: EXIST 6F NiTi Stent System FLEX|DEVICE: EXIST 6F NiTi Stent System PULL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel to Duac® Topical Gel in the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel|DRUG: Duac® Topical Gel|DRUG: Placebo Topical Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: High Definition Transcranial Direct Current Stimulation (HD-tDCS) for Early Alzheimer's Disease
Status: RECRUITING
Conditions: Transcranial Direct Current Stimulation|Functional Magnetic Resonance Imaging|Early Alzheimer's Disease
Interventions: OTHER: HD-tDCS|OTHER: computer-based cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Finasteride in Treating Patients With Stage II Prostate Cancer Who Are Undergoing Surgery
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate|Stage II Prostate Cancer
Interventions: DRUG: Finasteride|OTHER: Placebo|PROCEDURE: Prostatectomy|OTHER: Laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mobile-health Intervention to Promote Oral Health in Adolescents: A Cluster Randomized Controlled Trial
Status: RECRUITING
Conditions: Oral Health
Interventions: BEHAVIORAL: Family HBM- mobile messaging|BEHAVIORAL: Adolescent HBM- mobile messaging|BEHAVIORAL: Adolescent e-pamphlets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Chemotherapy With WH002 in Women With HER2-negative Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: WH002|DRUG: paclitaxel injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interferon for the Intervention of Molecular Relapse in t (8; 21) AML After Allo-HSCT
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Interferon-alpha
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: No Surgery Trial / Two Dose-escalation Strategies
Status: RECRUITING
Conditions: Stage II Rectal Cancer
Interventions: PROCEDURE: Complete responders and Non-complete responders|RADIATION: Chemoradiation + EBRT Boost|RADIATION: Chemoradiation + HDRBT Boost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addition of Pudendal Blocks to Pelvic Floor Physical Therapy for the Treatment of Pelvic Floor Tension Myalgia
Status: COMPLETED
Conditions: Pelvic Floor Muscle Spasm
Interventions: DRUG: Pudendal block|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Anti-CD19/CD22 CAR NK Cells in Relapsed and Refractory B Cell Lymphoma
Status: UNKNOWN
Conditions: Refractory B-Cell Lymphoma
Interventions: BIOLOGICAL: Anti-CD19/CD22 CAR NK Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerance of Healthy Term Infants Fed Infant Formulas #3
Status: COMPLETED
Conditions: Gastrointestinal Tolerance
Interventions: OTHER: Experimental milk protein infant formula Process A|OTHER: Experimental milk protein infant formula Process B|OTHER: Experimental milk protein infant formula Process C|OTHER: Experimental milk protein infant formula Process D|OTHER: Experimental milk protein infant formula Process E|OTHER: Experimental milk protein infant formula Process F
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Forceps vs Vacuum. Rate of Levator Ani Muscle Avulsion: Clinical Trial.
Status: UNKNOWN
Conditions: Birth Injuries|Pelvic Floor Disorders|Instrumental; Injury, Obstetric
Interventions: OTHER: Ultrasound diagnosis of avulsion of the levator ani muscle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Oxytocin and Social Cognitive Skills Groups
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Oxytocin|BEHAVIORAL: Social Cognitive Skills Training|BEHAVIORAL: Facilitated Play Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation as a Treatment for Pain in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Neuropathic Pain|Pain
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-06649751 in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: PF-06649751|DRUG: PF-06649751|DRUG: PF-06649751|DRUG: PF-06649751
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Acceptability and Safety of MR-C-014 in Persons With Neuromyelitis Optica Spectrum Disorder
Status: NOT_YET_RECRUITING
Conditions: Neuromyelitis Optica Spectrum Disorder
Interventions: DEVICE: MR-C-014
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Time Dependent Effects of tDCS Combined With MT for Rehabilitation After Subacute and Chronic Stroke
Status: COMPLETED
Conditions: Cerebrovascular Accident
Interventions: BEHAVIORAL: sequentially apply tDCS and MT|BEHAVIORAL: apply tDCS concurrently|BEHAVIORAL: MT with sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tazemetostat With Enzalutamide or Abiraterone/Prednisone in Participants With Advanced Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Prostate Cancer|Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: Tazemetostat|DRUG: Abiraterone/prednisone|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone for Reduction of Post Thoracotomy Pain Syndrome
Status: RECRUITING
Conditions: Chronic Pain|Dexamethasone|Thoracic Surgery|Cytokines
Interventions: DRUG: Dexamethasone|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Efficacy and Safety of CDK4/6 Inhibitor SHR6390 Combined With Pyrotinib in the Treatment of HER2-positive Advanced Breast Cancer
Status: UNKNOWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Pyrotinib combine with SHR6390
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Rates of Anastomotic Leak in Patients Undergoing Colo-rectal Surgery When Bowel Perfusion and Resection Margin is Deterimined by Intra-operative Infra-red Thermography or by Conventional Method
Status: COMPLETED
Conditions: Colo-rectal Surgery|Anastomotic Leak Large Intestine|Anastomotic Leak Rectum
Interventions: OTHER: Intra-operative Infra-red thermography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of LaNova Medicines(LM)-302 in Combination With Toripalimab in Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Advanced Solid Tumor
Interventions: DRUG: LM-302|DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation of a Multi-component, Supervised Exercise Program for Patients With Type 2 Diabetes Mellitus.
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Exercise
Interventions: BEHAVIORAL: CrossFit group exercise classes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Multi-modal Intervention Care on Cachexia in Patients With Advanced Cancer Compared to Conventional Management (MIRACLE)
Status: UNKNOWN
Conditions: Gastric Cancer|Colorectal Cancer|Pancreatic Cancer|Biliary Tract Cancer|Lung Cancer|Precachexia|Cachexia
Interventions: COMBINATION_PRODUCT: Multi-modal intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors
Status: COMPLETED
Conditions: Cardiovascular Disease|High Cardiovascular Risk|Obesity|Overweight|Type 2 Diabetes
Interventions: DRUG: Lorcaserin hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cilengitide (EMD 121974) for Recurrent Glioblastoma Multiforme (Brain Tumor)
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Cilengitide 500 mg|DRUG: Cilengitide 2000 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BARD® Study of LIFESTREAM™ Balloon Expandable Covered Stent Treating Iliac Arterial Occlusive Disease
Status: COMPLETED
Conditions: Peripheral Artery Disease|Peripheral Vascular Disease|Arterial Occlusive Disease
Interventions: PROCEDURE: Percutaneous transluminal angioplasty (PTA)|DEVICE: LIFESTREAM™ covered stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal Intervention in Patients With Non-specific Chronic Low Back Pain: the HEALTHY BACK Project
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain, Chronic|Neurologic Manifestations|Back Pain|Low Back Pain|Behavior, Health
Interventions: BEHAVIORAL: Multimodal + Resistance Programs|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraperitoneal Infusion of Analgesic for Postoperative Pain Management
Status: RECRUITING
Conditions: Hysterectomy|Gynecologic Surgical Procedures|Narcotic Use|Pain, Postoperative
Interventions: DRUG: Ropivacaine Infusion from ON-Q Pump|DRUG: Ropivacaine + Ketorolac Infusion from ON-Q Pump|DRUG: Normal Saline Infusion from ON-Q Pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS)
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: DRUG: Adalimumab|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Theta Burst Stimulation on Cognitive Impairment of Cerebral Small Vessel Disease
Status: NOT_YET_RECRUITING
Conditions: Cerebral Small Vessel Diseases|Cognitive Impairment
Interventions: DEVICE: iTBS|DEVICE: sham iTBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tree Nut Consumption to Reduce Abdominal Adiposity
Status: COMPLETED
Conditions: Millenials|Risk for Metabolic Syndrome
Interventions: OTHER: High Carbohydrate or Tree Nut Food Snacks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mitigation Efforts in Arsenic Exposure With Folic Acid Supplementation
Status: ENROLLING_BY_INVITATION
Conditions: Arsenic and/or Arsenic Compound Adverse Reaction
Interventions: DIETARY_SUPPLEMENT: Folic Acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prevention of Vascular Access Graft Failure in Patients With Chronic Renal Failure Requiring Hemodialysis
Status: TERMINATED
Conditions: Hyperplasia|Chronic Renal Failure
Interventions: DRUG: edifoligide (E2F Decoy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Increasing Documentation and Disclosure of Sickle Cell Trait Status: An Implementation Science Approach
Status: RECRUITING
Conditions: Sickle Cell Trait
Interventions: BEHAVIORAL: SCT Documentation and Disclosure Toolkit (SCT-DD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: PLACEBO-CONTROLLED SAFETY STUDY OF RITLECITINIB (PF-06651600) IN ADULTS WITH ALOPECIA AREATA
Status: TERMINATED
Conditions: Alopecia Areata
Interventions: DRUG: PF-06651600|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: State Representation in Early Psychosis
Status: RECRUITING
Conditions: Psychosis|Schizophrenia|Schizophrenia Spectrum and Other Psychotic Disorders|Schizoaffective Disorder
Interventions: DEVICE: Computerized Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of SiD's System for Improving Assisted Reproduction Treatments
Status: COMPLETED
Conditions: Infertility
Interventions: DEVICE: Software assisted selection of individual spermatozoa for intracytoplasmic sperm injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential Therapy Versus Triple Therapy for Helicobacter Pylori Eradication: a Placebo-controlled Trial
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Placebo amoxicillin pantoprazole clarithromycin tinidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Selenomethionine in Treating Patients Undergoing Surgery or Internal Radiation Therapy for Stage I or Stage II Prostate Cancer
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: selenomethionine|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy After Surgery With or Without Chinese Herbal Therapy to Treat Symptoms in Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Drug/Agent Toxicity by Tissue/Organ
Interventions: DIETARY_SUPPLEMENT: Chinese herbs|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetics of Everolimus in Absorb BVS in Patients With Coronary Artery Lesions
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Artery Stenosis|Coronary Disease|Coronary Stenosis
Interventions: DEVICE: Coronary artery stenting: Absorb BVS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab and Gemcitabine for Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Status: TERMINATED
Conditions: Lymphoma, B-Cell
Interventions: DRUG: Rituximab|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Effectiveness and Safety Study of Acetaminophen 1000 mg and Ibuprofen 400 mg in Postoperative Dental Pain
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: placebo|DRUG: acetaminophen|DRUG: ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety of mRNA-0184 in Participants With Heart Failure
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Heart Failure
Interventions: DRUG: mRNA-0184|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients
Status: COMPLETED
Conditions: Heart Failure|Respiratory Insufficiency|Stroke Acute|Infectious Diseases|Rheumatic Diseases
Interventions: DRUG: Rivaroxaban, 10 mg|DRUG: Rivaroxaban, 7.5 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Effect of Acidic Vaginal pH on the Efficacy of Dinoprostone for Labor Induction
Status: COMPLETED
Conditions: Labor, Induced|Induced; Birth
Interventions: OTHER: Vaginal washing with 5% acetic acid|OTHER: Vaginal washing with 0.9% NS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Medical Supervised Duodenal-Enteral Feeding Treatment
Status: COMPLETED
Conditions: Obesity|Obesity, Visceral|Overweight and Obesity|Body Fat Disorder|Feeding and Eating Disorders|Hormone Disturbance|Weight Loss
Interventions: DIETARY_SUPPLEMENT: Nasogastroduodenal Protocol|OTHER: Control|OTHER: Data analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HYDROchlorothiazide to PROTECT Polycystic Kidney Disease Patients and Improve Their Quality of Life
Status: NOT_YET_RECRUITING
Conditions: ADPKD
Interventions: DRUG: Hydrochlorothiazide 25 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Neratinib Plus Capecitabine in Subjects With HER2-Negative Metastatic Breast Cancer With Brain Metastases and Abnormally Active HER2 Signaling
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Capecitabine and Neratinib.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aqueous Humor Concentration of InSite Vision (ISV) 303 (Bromfenac in DuraSite) to Bromday Once Daily (QD) Prior to Cataract Surgery
Status: COMPLETED
Conditions: Cataract
Interventions: DRUG: ISV-303|DRUG: Bromday™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Iron/Zinc-Biofortified Pearl Millet on Growth and Immunity in Children Aged 12-18 Months in India
Status: COMPLETED
Conditions: Iron Deficiency|Zinc Deficiency
Interventions: OTHER: FeZnPM|OTHER: CtrlPM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: tailOred dRug repurposIng of dEcitabine in KRAS-dependeNt refracTory pAncreaTic cancEr
Status: RECRUITING
Conditions: Pancreatic Adenocarcinoma Metastatic|Pancreatic Adenocarcinoma Recurrent
Interventions: DRUG: Decitabine 50 MG [Dacogen]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Pre-emptive Analgesics on Post-Operative Pain After Stainless Steel Crown Placement On Primary Molars
Status: COMPLETED
Conditions: Post-operative Pain
Interventions: DRUG: Ibuprofen|DRUG: Paracetamol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antigen-specific Cytotoxic T Cells in the Treatment of Opportunistic Infections
Status: UNKNOWN
Conditions: Pathogen Infection|EBV Infection|CMV Infection|Adenovirus Infection|BKV Infection|Fungus Infection|Tuberculosis
Interventions: BIOLOGICAL: pathogen-specific CTLs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anesthetic Gas Leakage in Children During Tonsillectomy: a Comparison of Cuffed and Uncuffed Tracheal Tubes
Status: COMPLETED
Conditions: Exposure to Environmental Pollution|Adverse Effect of Unspecified General Anesthetic
Interventions: DRUG: oxygen concentration|DRUG: nitrous oxide concentration|DRUG: carbon dioxide concentration|DRUG: sevoflurane concentration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: S0226 Anastrozole With or Without Fulvestrant as First-Line Therapy in Postmenopausal Women With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: anastrozole|DRUG: fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Negative Stressful Perseverations in Insomnia to Revitalize Expecting Moms (INSPIRE)
Status: RECRUITING
Conditions: Insomnia|Depression
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia (CBTI)|BEHAVIORAL: Perinatal Understanding of Mindful Awareness for Sleep (PUMAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Ramucirumab Plus Paclitaxel as Switch MANteInance Versus Continuation of First-line Chemotherapy in Patients With Advanced HER-2 Negative Gastric or Gastroesophageal Junction Cancers
Status: UNKNOWN
Conditions: Stomach Neoplasms
Interventions: DRUG: RAMUCIRUMAB|DRUG: Paclitaxel|DRUG: FOLFOX 4|DRUG: mFOLFOX 6|DRUG: XELOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Recombinant Endostatin Combined With Chemotherapy to Treat Advanced Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: Endostatins (Endostar)|DRUG: Oxaliplatin|DRUG: Leucovorin|DRUG: 5-fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a New Critical Pathway for Treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI)
Status: COMPLETED
Conditions: Acute Bacterial Skin and Skin Structure Infections
Interventions: DRUG: Usual Care|DRUG: Dalbavancin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Cross-sectional Coordinated, Severity Stepped, Evidence-based Care Model for Mental Disorders
Status: COMPLETED
Conditions: Delivery of Health Care
Interventions: BEHAVIORAL: RECOVER|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sarcopenia in Axial and Peripheral Spondyloarthropathies
Status: COMPLETED
Conditions: Spondylarthropathy|Sarcopenia
Interventions: OTHER: Dynamometry exam|OTHER: Walking test|RADIATION: DXA measurement|OTHER: SARQOL questionnaire|BEHAVIORAL: Life habits Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Umbilical Cord Blood and Placental Blood Transplantation in Treating Patients With Hematologic Cancer or Aplastic Anemia
Status: UNKNOWN
Conditions: Childhood Langerhans Cell Histiocytosis|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: PROCEDURE: umbilical cord blood transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Gut Permeability, Sensitivity and Symptomatology
Status: COMPLETED
Conditions: Irritable Bowel Syndrome|Visceral Hypersensitivity
Interventions: PROCEDURE: Gastrointestinal Permeability Test|PROCEDURE: Upper Endoscopy|PROCEDURE: Rectal Barostat and Infusion of Fats
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy Study of a Low Volume of Water Intake and Mosapride for Endoscopy in Patients With Subtotal Gastrectomy
Status: COMPLETED
Conditions: Foreign Body Left During Endoscopic Examination
Interventions: DRUG: Mosapride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: START NOW Adapted: Culturally Adapted Version of START NOW
Status: RECRUITING
Conditions: Depression|Depression/Anxiety|Anxiety|Adolescent|Emotion Recognition|Mental Health|Resilience,Psychological|Refugee Health
Interventions: BEHAVIORAL: START NOW Adapted
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy Of The Wavelight Mydon Laser for Hair Removal And Treatment of Leg Veins
Status: COMPLETED
Conditions: Leg Veins|Hair Removal
Interventions: DEVICE: Laser Treatment|DEVICE: Wave Light laser device for skin treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tissue-engineered Skin Graft Repair of Autologous Scar Dermal Scaffolds
Status: RECRUITING
Conditions: Scar
Interventions: PROCEDURE: Tissue-engineered skin grafts of autologous scar dermal scaffolds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-marketing Surveillance of Donepezil Hydrochloride -Investigation of the Factors That Affect Aricept Medication Persistence Rate and the Safety and Efficacy in Patients With Alzheimer's Disease in Clinical Practice
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Donepezil Hydrochloride
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Non-invasive Blood-brain Barrier Opening in Alzheimer's Disease Patients Using Focused Ultrasound
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DEVICE: Neuronavigation-guided single-element focused ultrasound transducer|DRUG: Definity|OTHER: Magnetic Resonance Imaging (MRI) with or without gadolinium contrast agents|OTHER: Positron Emission Tomography (PET)|OTHER: Amyvid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study of Azacitidine for Patients With Int/High -Risk MDS and AML-MRC
Status: UNKNOWN
Conditions: Myelodysplastic Syndromes,Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine combined HHT|DRUG: Azacitidine regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-Centre, Open-Label, Two Segment, Study Comparing Plasma Pharmacokinetics of Ketoprofen in Diractin® Alone to Diractin® Applied Concomitant With Heat or Moderate Exercise
Status: COMPLETED
Conditions: Pharmacokinetic
Interventions: DRUG: Diractin|DRUG: Diractin|DRUG: Diractin|DRUG: Diractin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A Mechanistic Study to Evaluate the Efficacy of Montelukast on Airway Function in Asthma
Status: UNKNOWN
Conditions: Asthma
Interventions: DRUG: Montelukast|DRUG: Placebo for montelukast|OTHER: Inhaled leukotriene E4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: TinCat LGBTQ+ Smoking Cessation Via Asynchronous Telehealth
Status: UNKNOWN
Conditions: Tobacco Use Disorder|Tobacco Use Cessation
Interventions: BEHAVIORAL: TinCat|BEHAVIORAL: Quit.gov program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Vaccine in Adults at Occupational Risk for Influenza A (H5N1) Exposure
Status: WITHDRAWN
Conditions: Influenza
Interventions: BIOLOGICAL: GSK influenza virus H5N1 vaccine 1557484A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Brain Energy for Amyloid Transformation in Alzheimer's Disease Study
Status: RECRUITING
Conditions: Alzheimer Disease|Mild Cognitive Impairment
Interventions: OTHER: low carbohydrate/high fat diet|OTHER: low fat/high carbohydrate diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness And Safety Of Donepezil Hydrochloride (E2020) In Subjects With Mild To Severe Alzheimer's Disease Residing In An Assisted Living Facility
Status: COMPLETED
Conditions: Mild to Severe Alzheimer's Disease
Interventions: DRUG: Donepezil HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 28 - 90 Days Study to Evaluate the Safety, Tolerability, and Efficacy of Caspofungin Injection as Empirical Therapy in Indian Adults With Persistent Fever and Neutropenia (0991-053)(COMPLETED)
Status: COMPLETED
Conditions: Fungal Infection
Interventions: DRUG: caspofungin acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of EMDR in Patients With PTSD in Multiple Sclerosis
Status: UNKNOWN
Conditions: Posttraumatic Stress Disorders|Multiple Sclerosis
Interventions: BEHAVIORAL: EMDR|BEHAVIORAL: Relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT