pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Auricular Neurostimulation for Chemotherapy Induced Nausea and Vomiting
Status: RECRUITING
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: DEVICE: Auricular percutaneous neurostimulation|DEVICE: Sham percutaneous neurostimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: EPISPOT Detection of Circulating Prostate Cells Among Adenocarcinoma Patients
Status: UNKNOWN
Conditions: Adenocarcinoma of the Prostate
Interventions: BIOLOGICAL: EPISPOT detection of the number of circulating cells|BIOLOGICAL: CellSearch detection of the number of circulating, functional, prostate cells
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Bioavailability of Dexketoprofen Trometamol Oral Solution vs Tablet Formulations
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: Enantyum® oral solution|DRUG: Keral® tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Vasopressin in Intraabdominal Pressure Elevation
Status: ACTIVE_NOT_RECRUITING
Conditions: Intracranial Pressure Increase|Abdominal Compartment Syndrome
Interventions: DIAGNOSTIC_TEST: Study Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of MT-3995 in Patients With Non-Alcoholic Steatohepatitis(NASH)
Status: COMPLETED
Conditions: NASH
Interventions: DRUG: MT-3995|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Polyethylene Glycol Interferon Alfa-2b (PEG Intron) Versus Interferon Alfa-2b (INTRON^® A) in the Treatment of Newly Diagnosed Chronic Myelogenous Leukemia (CML) (C98026)
Status: TERMINATED
Conditions: Chronic Myelogenous Leukemia
Interventions: BIOLOGICAL: Pegylated interferon alfa-2b|BIOLOGICAL: Interferon alfa-2b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azithromycin for Acute Exacerbations Requiring Hospitalization
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Azithromycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of Long Chain Omega-3 Fatty Acids From a Gastric Stable Emulsion
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Omega-3 oils from tri-glycerides|DIETARY_SUPPLEMENT: Omega-3 oils from marine phospholipids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluating the Safety and Priming Response of an HIV Vaccine Regimen in Healthy, HIV-Uninfected Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: DNA-HIV-PT123|BIOLOGICAL: NYVAC-HIV-PT1|BIOLOGICAL: NYVAC-HIV-PT4|BIOLOGICAL: AIDSVAX® B/E|BIOLOGICAL: Placebo for DNA/NYVAC|BIOLOGICAL: Placebo for AIDSVAX(R) B/E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate Romosozumab in Children and Adolescents With Osteogenesis Imperfecta
Status: COMPLETED
Conditions: Osteogenesis Imperfecta
Interventions: DRUG: Romosozumab|DIETARY_SUPPLEMENT: Calcium|DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Efficacy and Safety of Metformin in Treatment of Moderate Psoriasis
Status: UNKNOWN
Conditions: Psoriasis
Interventions: DRUG: Metformin|DRUG: Placebo|DRUG: Topical Coal tar|DRUG: Topical calcipotriol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study on Sunitinib as First Line Therapy for Advanced/Metastatic Renal Cell Carcinoma in Asian Population
Status: TERMINATED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Sunitinib malate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Study the Efficacy and Safety of an Investigational Drug in Acutely Psychotic People With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: SEP-363856 50mg|DRUG: SEP-363856 75mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of CAR.70-engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Advanced Renal Cell Carcinoma, Mesothelioma and Osteosarcoma
Status: RECRUITING
Conditions: Advanced Renal Cell Carcinoma|Advanced Mesothelioma|Advanced Osteosarcoma
Interventions: DRUG: CAR.70/IL15-transduced CB-derived NK cells|DRUG: Fludarabine phosphate|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Pycnogenol® to Alleviate Menopausal Symptoms Induced or Increased by Breast and Gynecological Cancer Treatments
Status: UNKNOWN
Conditions: Climacteric; Menorrhagia, Menopausal|Menopause
Interventions: DIETARY_SUPPLEMENT: 50 mg PYC and then placebo|DIETARY_SUPPLEMENT: 100 mg PYC and then placebo|DIETARY_SUPPLEMENT: Placebo and then 50 mg PYC|DIETARY_SUPPLEMENT: Placebo and then 100 mg PYC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Effects of Steroids in Obese Men
Status: UNKNOWN
Conditions: Obesity|Insulin Resistance
Interventions: DRUG: Anastrazole|DRUG: Testosterone|DRUG: Dutasteride|DRUG: GnRH antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of 5G Radiation on Skin
Status: RECRUITING
Conditions: Electromagnetic Radiation (5GFR2)
Interventions: RADIATION: 5GFR2 non ionizing EMW exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Risk Factors for Vascular Calcifications in Hemodialysis Patients: to What Extent is Vitamin K2 Deficiency Involved?
Status: COMPLETED
Conditions: Vascular Calcifications
Interventions: DRUG: Menaquinone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Transcutaneous Electrical Nerve Stimulation on Pain During Propofol Injection
Status: UNKNOWN
Conditions: Transcutaneous Electrical Nerve Stimulation|Pain|Propofol Adverse Reaction
Interventions: DEVICE: transcutaneous electrical nerve stimulation|DEVICE: Placebo transcutaneous electrical nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Levocetirizine for Treatment of Recurrent Cough Associated With Other Allergic Symptoms in Children
Status: COMPLETED
Conditions: Cough
Interventions: DRUG: levocetirizine dihydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brimonidine for Subconjunctival Hemorrhage From Femtosecond Laser Assisted Cataract Surgery
Status: COMPLETED
Conditions: Subconjunctival Hemorrhage|Cataract Surgery
Interventions: DRUG: Brimonidine Tartrate 0.15% Oph Soln
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of GLP-1 on Insulin Biosynthesis and Turnover Rates
Status: TERMINATED
Conditions: Type 2 Diabetes
Interventions: DRUG: glucagon like peptide-1|DIETARY_SUPPLEMENT: glucose control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sevoflurane vs Propofol Effect on Endothelial Damage Markers After Knee Ligament Surgery.
Status: COMPLETED
Conditions: Ischemia Reperfusion Injury
Interventions: DRUG: Sevoflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Telerehabilitation in Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: VRRS Khymeia|BEHAVIORAL: Usual care program|BEHAVIORAL: VRRS Khymeia plus active tDCS|BEHAVIORAL: VRRS Khymeia plus placebo tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Urodynamic Effects of UK-369,003 in Men With Lower Urinary Tract Symptoms
Status: COMPLETED
Conditions: Prostatic Hyperplasia
Interventions: DRUG: UK-369,003|DRUG: UK-369,003
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Johnsonii in Children and Adolescents With T1D
Status: RECRUITING
Conditions: Type 1 Diabetes (T1D)
Interventions: DRUG: L. johnsonii Probiotic|DRUG: Placebo Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: BCI-FES for Upper Limb Rehabilitation in Chronic Stroke
Status: NOT_YET_RECRUITING
Conditions: Stroke|Upper Extremity Paresis|Neuronal Plasticity
Interventions: DEVICE: Functional Electrical Stimulation Therapy coupled to a P-300 based Brain-Computer Interface|OTHER: Conventional Physical and Occupational Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Glucocorticoid Administration in the Treatment of Adult Distal Radius Fractures
Status: RECRUITING
Conditions: Distal Radius Fracture
Interventions: DRUG: Dexamethasone|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abdominal Aortic Aneurysm Sac Healing and Prevention of Endoleaks
Status: ACTIVE_NOT_RECRUITING
Conditions: Abdominal Aortic Aneurysm
Interventions: DEVICE: IMPEDE-FX Embolization Plug
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of AccuCath IV Catheter and Conventional IV Catheter in Interventional Radiology
Status: COMPLETED
Conditions: Vascular Access Complications
Interventions: DEVICE: AccuCath IV Catheter System|DEVICE: Conventional IV Catheter System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weight Loss for a Healthier You Programme
Status: UNKNOWN
Conditions: Ketogenic Dieting|Weight Loss|Obesity|Metabolic Syndrome
Interventions: OTHER: Calorie-Restricted Healthy Ketogenic Diet|OTHER: Calorie-Restricted Low Fat Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Demonstrate the Relative Bioequivalence of Cefdinir and Omnicel 300 mg Capsule Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cefdinir 300 mg Capsule (Sandoz, Austria)|DRUG: Omnicef Cefdinir 300 mg Capsule (Abbott Laboratories, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term, Open-label Safety Extension Study of Retigabine/Ezogabine in Pediatric Subjects (>= 12 Years Old) With POS or LGS
Status: TERMINATED
Conditions: Epilepsy
Interventions: DRUG: retigabine/ezogabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NY-ESO-1 Protein Vaccine With Imiquimod in Melanoma (Adjuvant Setting)
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: DRUG: Imiquimod|BIOLOGICAL: NY-ESO-1 protein
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Ascending Dose Study of Soluble Ferric Pyrophosphate Administered Intravenously in Healthy Volunteers.
Status: COMPLETED
Conditions: Kidney Failure, Chronic Therapy; Hemodialysis
Interventions: DRUG: soluble ferric pyrophosphate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Working Memory Training in COPD Patients: the Cogtrain-Trial
Status: COMPLETED
Conditions: COPD|Cognitive Impairment
Interventions: OTHER: Working memory training|BEHAVIORAL: Standardised healthy lifestyle coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study Assessing Safety and Efficacy of DE-101 Ophthalmic Suspension in Dry Eye Patients
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: DE-101 ophthalmic suspension|DRUG: DE-101 ophthalmic suspension|DRUG: DE-101 ophthalmic suspension vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ACE527 Safety and Immunogenicity Study
Status: COMPLETED
Conditions: Enterotoxigenic E. Coli (ETEC) Infection
Interventions: BIOLOGICAL: ACE527 vaccine|BIOLOGICAL: Placebo vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Suvorexant and Trauma Related Insomnia
Status: COMPLETED
Conditions: Insomnia|Posttraumatic Stress Disorder
Interventions: DRUG: suvorexant|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Value of Short-term Pain Relief for the Prediction of Long-term Outcome After Cervical or Lumbar Nerve Root Infiltration
Status: COMPLETED
Conditions: Cervical Disc Herniation|Lumbar Disc Herniation
Interventions: PROCEDURE: Cervical nerve root infiltration|PROCEDURE: Lumbar nerve root infiltration|DRUG: Mephamesone|DRUG: 0.5% bupivacaine (Bupivacain®)|DRUG: Kenacort®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Muscular Imbalance Between Flexors and Extensors of the Fingers and Wrist on Upper Limb Injuries in Climbers
Status: RECRUITING
Conditions: Climber
Interventions: OTHER: The strength values of the flexors and extensors of the fingers and wrist will be measured using a dynamometer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevention of New Onset AF After TAVI (PAF-TAVI Trial)
Status: UNKNOWN
Conditions: Atrial Fibrillation New Onset
Interventions: PROCEDURE: transcatheter aortic valve implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Automated Hovering for Congestive Heart Failure Patients
Status: COMPLETED
Conditions: Heart Failure
Interventions: BEHAVIORAL: Electronic pill bottle|BEHAVIORAL: Bluetooth scale|BEHAVIORAL: Support Partner|BEHAVIORAL: Engagement incentives
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Camp High 5: Evaluation of the Effect on Upper Limb Function
Status: COMPLETED
Conditions: Neurological Injury|Hemiplegia
Interventions: BEHAVIORAL: Constraint induced movement therapy (CIMT)|BEHAVIORAL: Hand-arm bimanual intensive training (HABIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neural Mechanisms of Cannabinoid-impaired Decision-Making in Emerging Adults
Status: COMPLETED
Conditions: Neurosciences|Substance-Related Disorders|Behavior Problem
Interventions: DEVICE: Placebo TMS Sham|DRUG: Marinol 10Mg Capsule TMS Sham|DRUG: Marinol 30Mg Capsule TMS Sham|DEVICE: Placebo TMS Real|OTHER: Marinol 10Mg Capsule TMS Real|OTHER: Marinol 30Mg Capsule TMS Real
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Examining Risk Factors for Atypical Antipsychotic Metabolic Side Effects
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DIETARY_SUPPLEMENT: Folic Acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Efficacy of MEDI-528 on Late Asthmatic Response With Atopic Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: MEDI-528 9 mg/kg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lansoprazole on Gastric and Duodenal Ulcers in Patients Taking Nonsteroidal Anti-Inflammatory Drugs
Status: COMPLETED
Conditions: Stomach Ulcer|Duodenal Ulcer
Interventions: DRUG: Lansoprazole|DRUG: Gefarnate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Buxue Yimu Pills for Gynecological Iron-Deficiency Anemia
Status: UNKNOWN
Conditions: Iron-Deficiency Anemia
Interventions: DRUG: Buxue Yimu Pills|DRUG: Buxue Yimu Pills &Ferrous Sulfate|DRUG: Ferrous Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Activation of Hippo Pathway in Nasal Polyps
Status: UNKNOWN
Conditions: Nasal Polyps
Interventions: PROCEDURE: functional endonasal sinus surgery|PROCEDURE: nasal septal construction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: XEN45 in the Treatment of Chinese Patients With Primary Open-angle Glaucoma
Status: UNKNOWN
Conditions: Glaucoma|Glaucoma, Open-Angle|Surgery
Interventions: PROCEDURE: XEN45 gel stent implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-blind, Placebo-controlled, Randomised Withdrawal, Extension, Safety and Efficacy Study of LDX in Children and Adolescents Aged 6-17
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: Lisdexamfetamine dimesylate (LDX)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: How Environmental Interventions Influence Behavior in School Lunchrooms
Status: COMPLETED
Conditions: Child Behavior|Adolescent Behavior|Health Behavior
Interventions: BEHAVIORAL: USDA Regulations|BEHAVIORAL: Marketing Kit|BEHAVIORAL: Smarter Lunchrooms Makeover (SLM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study in Which Therapy is Either Switched to Nivolumab After 3 Months of Treatment or Therapy is Continued With a Tyrosine Kinase Inhibitor in Patients With Metastatic Renal Cell Carcinoma (RCC) and Disease Control
Status: TERMINATED
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: Nivolumab|DRUG: Sunitinib|DRUG: Pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of ONO-4538 in Combination With Ipilimumab and Chemotherapy in Chemotherapy-naïve Participants With HER2-negative Unresectable Advanced or Recurrent Gastric Cancer (Including Esophagogastric Junction Cancer)
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: ONO-4538|DRUG: Ipilimumab|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Potency of Topical Corticosteroids in Combination Preparations
Status: UNKNOWN
Conditions: Skin Toxicity
Interventions: COMBINATION_PRODUCT: Combination topical corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of RVT-1201 in Patients With Pulmonary Arterial Hypertension (ELEVATE 1)
Status: TERMINATED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: RVT-1201|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Glycophosphopeptical AM3 A Potential Adjuvant in the Treatment of SARS-CoV-2
Status: UNKNOWN
Conditions: SARS-CoV-2 Infection
Interventions: DIETARY_SUPPLEMENT: glycophosphopeptical AM3|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Piwi-protein Interacting RNA, miRNA-194 and Amino Acids in Patients With Prostate Cancer
Status: UNKNOWN
Conditions: Finding New Biomarkers That Could be Evaluated in Patients With Prostate Cancer and Clarify Their Role in Early Detection of Prostate Cancer
Interventions: DIAGNOSTIC_TEST: piRNAs, miRNA-194, regucalcin and plasma aminoacids levels
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Buffered Lidocaine in Paracervical Blocks
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Lidocaine|DRUG: Lidocaine-Sodium Bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cilengitide in Treating Younger Patients With Recurrent or Progressive High-Grade Glioma That Has Not Responded to Standard Therapy
Status: COMPLETED
Conditions: Childhood High-grade Cerebellar Astrocytoma|Childhood High-grade Cerebral Astrocytoma|Recurrent Childhood Anaplastic Astrocytoma|Recurrent Childhood Anaplastic Oligoastrocytoma|Recurrent Childhood Anaplastic Oligodendroglioma|Recurrent Childhood Brain Tumor|Recurrent Childhood Cerebellar Astrocytoma|Recurrent Childhood Cerebral Astrocytoma|Recurrent Childhood Glioblastoma|Recurrent Childhood Visual Pathway and Hypothalamic Glioma
Interventions: DRUG: cilengitide|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study Looking at the Comparability (Bioequivalence) of Two Versions of Semaglutide
Status: COMPLETED
Conditions: Healthy Volunteers|Overweight|Obesity
Interventions: DRUG: Semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GnRH for Luteal Support in IVF/ICSI/FET Cycles
Status: RECRUITING
Conditions: Infertility
Interventions: DRUG: GnRH|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Observational Study of DME Following Scatter Laser Photocoagulation
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: PROCEDURE: Scatter Laser Photocoagulation in 1 Sitting|PROCEDURE: Scatter Laser Photocoagulation in 4 Sittings
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: EUS BD vs ERCP TP for Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer|Pancreatic Adenocarcinoma|Biliary Tract Neoplasms|Biliary Duct Obstruction|Unresectable Pancreatic Cancer|Periampullary Cancer|Periampullary Carcinoma Non-Resectable
Interventions: PROCEDURE: Endoscopic Ultrasound Guided Biliary Drainage|PROCEDURE: ERCP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety, Engraftment, and Action of Multi-Dosed NB01 in Adults With Moderate Acne
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: BIOLOGICAL: NB01|OTHER: Vehicle Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating GS-9620 in Virologically Suppressed Subjects With Chronic Hepatitis B Virus Infection
Status: COMPLETED
Conditions: Hepatitis B
Interventions: DRUG: Single Ascending Dose (SAD) Cohorts GS-9620|DRUG: Multiple Ascending Dose (MAD) Cohorts GS-9620
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Domperidone for Relief of Gastrointestinal Disorders
Status: TERMINATED
Conditions: Gastroparesis|GERD|Esophagitis|Dyspepsia|Chronic Idiopathic Constipation|Nausea|Vomiting
Interventions: DRUG: Domperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atrial Fibrillation Ablation Compared to Rate Control Strategy in Patients With Impaired Left Ventricular Function
Status: UNKNOWN
Conditions: Persistent Atrial Fibrillation|Congestive Heart Failure Due to Left Ventricular Systolic Dysfunction
Interventions: PROCEDURE: Atrial fibrillation catheter ablation|PROCEDURE: Rate control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-retroviral Therapy, Medications for Opioid Use Disorder, Opioids and HIV Infection - Study 1
Status: RECRUITING
Conditions: Opioid-use Disorder|HIV-1-infection|Immune Activation|Inflammation|Methadone|Buprenorphine|Naltrexone|Antiretroviral Treatment
Interventions: DRUG: Methadone|DRUG: Buprenorphine/naloxone|DRUG: XR-Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of FOLFOX Versus FOLFOX Plus Aflibercept in K-ras Mutant Patients With Resectable Liver Metastases
Status: WITHDRAWN
Conditions: Colorectal Cancer Metastatic|Liver Metastases|KRAS Mutated Colorectal Cancer
Interventions: DRUG: Modified FOLFOX6|BIOLOGICAL: Aflibercept|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computed Tomography-Guided Nasotracheal Intubation Procedure
Status: COMPLETED
Conditions: Computed Tomography-guided Nasotracheal Intubation|The Space Where the Tube Will be Passed in the Internal Nasal Valve Region
Interventions: PROCEDURE: computed tomography-guided nasotracheal intubation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Medical Abortion With Single Daily Dose of Misoprostol
Status: COMPLETED
Conditions: Miscarriage
Interventions: DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aromatherapy for Postoperative Nausea and Vomiting in Children
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Aromatherapy inhaler|DRUG: Saline inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of S-033188 (Baloxavir Marboxil) Compared With Placebo or Oseltamivir in Otherwise Healthy Patients With Influenza
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: Baloxavir Marboxil|DRUG: Placebo to Baloxavir Marboxil|DRUG: Oseltamivir|DRUG: Placebo to Oseltamivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of the ACRYSOF® IQ EDF Intraocular Lens (IOL)
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: ACRYSOF® IQ Extended Depth of Focus IOL|DEVICE: ACRYSOF® IQ Monofocal IOL|PROCEDURE: Cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of i-STAT Analyzer Glucose, Hematocrit and Sodium for Capillary Samples
Status: COMPLETED
Conditions: Analytical Performance of Sodium, Glucose and Hematocrit Assays by the i-STAT 500 (Alinity) Analyzer
Interventions: DIAGNOSTIC_TEST: In-vitro
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Efficacy of Respiratory Pediatric Physiotherapy on a Child With Hospital Treated Pneumonia
Status: COMPLETED
Conditions: Pneumonia Childhood|Rehabilitation|Recovery of Function
Interventions: OTHER: Respiratory Pediatric Physiotherapy|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Explore the Efficacy and Mechanism of Action of Tezepelumab in Eosinophilic Granulomatosis With Polyangiitis
Status: ENROLLING_BY_INVITATION
Conditions: EGPA - Eosinophilic Granulomatosis With Polyangiitis
Interventions: DRUG: Tezepelumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pain-related Fear as a Facilitator of Nocebo Hyperalgesia
Status: COMPLETED
Conditions: Hyperalgesia|Chronic Pain Syndrome|Chronic Pain, Psychogenic|Fear of Pain
Interventions: BEHAVIORAL: Threat manipulation (control, no threat)|BEHAVIORAL: Threat manipulation|BEHAVIORAL: Conditioning of moderate pain|BEHAVIORAL: Conditioning of high pain|BEHAVIORAL: Extinction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cognitive Oriented Strategy Training Augmented Rehabilitation (COSTAR) Treatment Approach for Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: BEHAVIORAL: Cognitive-Oriented Strategy Augmented Rehabilitation (COSTAR)|BEHAVIORAL: Task Specific Training (TST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liraglutide Effect on Beta-cell Function in C-peptide Positive Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Liraglutide|DRUG: Placebo for liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NIBS With mCIMT for Motor and Functional Upper Limb Recovery in Stroke Patients.
Status: COMPLETED
Conditions: Stroke|Upper Extremity Paresis|Electric Stimulation|Occupational Therapy
Interventions: DEVICE: Active Bihemispheric Transcranial direct current Stimulation|DEVICE: Sham Bihemispheric Transcranial direct current Stimulation|OTHER: Modified Constraint Induced Movement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Azilsartan on Atrial Fibrillation in Patients With Hypertension
Status: NOT_YET_RECRUITING
Conditions: Hypertension|Atrial Fibrillation
Interventions: DRUG: Azilsartan or antihypertensive drugs other than ACEI, ARB or ARNI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose Finding for the Treatment of Rhinitis/Rhinoconjunctivitis Against Mite Allergy
Status: UNKNOWN
Conditions: Rhinitis|Rhinoconjunctivitis
Interventions: BIOLOGICAL: MM09 Mannosylated 5.000 subcutaneous|BIOLOGICAL: MM09 Mannosylated 10.000 subcutaneous|BIOLOGICAL: MM09 Mannosylated 30.000 subcutaneous|BIOLOGICAL: MM09 Mannosylated 50.000 subcutaneous|BIOLOGICAL: MM09 Mannosylated 5.000 sublingual|BIOLOGICAL: MM09 Mannosylated 10.000 sublingual|BIOLOGICAL: MM09 Mannosylated 30.000 sublingual|BIOLOGICAL: MM09 Mannosylated 50.000 sublingual|BIOLOGICAL: Subcutaneous placebo|BIOLOGICAL: Sublingual placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: A Phase II Combined Modality Protocol of Debulking Surgery With HIPEC Followed by Intraperitoneal Chemotherapy for the Treatment of Recurrent Ovarian, Primary Peritoneal & Fallopian Tube Cancers
Status: TERMINATED
Conditions: Recurrent Ovarian Cancer|Fallopian Tube Cancer
Interventions: DRUG: Cisplatin|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compassionate Treatment : An Exploratory Clinical Trial to Assess Treatment of Amyotrophic Lateral Sclerosis
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: PROCEDURE: Autologous Adipose-Tissue Derived Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Pharmacokinetics of NovoEight® (Turoctocog Alfa) in Relation to BMI in Subjects With Haemophilia A
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A
Interventions: DRUG: turoctocog alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperoxic Oxidative Stress During Abdominal Surgery
Status: COMPLETED
Conditions: Response to Hyperoxia
Interventions: OTHER: Fraction of inspired oxygen 40%|OTHER: Fraction of inspired oxygen 80%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Intranasal Abuse Potential of PF614 in Non-Dependent Recreational Opioid Users
Status: COMPLETED
Conditions: Recreational Drug Use
Interventions: DRUG: PF614|DRUG: Oxycodone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Follow-up of Myocardial T1 Relaxation Time in Patients With Anderson Fabry Disease
Status: UNKNOWN
Conditions: Anderson-Fabry Disease
Interventions: DRUG: Enzyme replacement therapy (Agalsidase alpha (Replagal®))|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Gefitinib With Chemotherapy or Anti-angiogenesis in NSCLC Patients With Bim Deletion or Low EGFR Mutation Abundance
Status: UNKNOWN
Conditions: Non-small-cell Lung Cancer
Interventions: DRUG: gefitinib combined with chemotherapy|DRUG: gefitinib combined with apatinib|DRUG: gefitinib single agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long Term Study to Assess the Safety of Fostamatinib in Patients in Asia With Rheumatoid Arthritis
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Fostamatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Trial, of Slow Release ASA, in Platelet Functionalism, a Long Term Treatment Period
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DRUG: Slow release acetyl salicylic acid|BEHAVIORAL: Antithrombotic effect
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Safety and Clinical Benefit of Injections Subcutaneously Talazoparib Versus Oral Talazoparib in Patients With Solid Tumors
Status: WITHDRAWN
Conditions: Advanced or Recurrent Solid Tumors|Breast Neoplasm
Interventions: BIOLOGICAL: Injections Subcutaneously Talazoparib|DRUG: Oral capsules Talazoparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Polyphenol-rich Cranberry Extract on Cardiometabolic and Neurocognitive Health
Status: UNKNOWN
Conditions: Abdominal Obesity
Interventions: DIETARY_SUPPLEMENT: Polyphenol-rich cranberry extract supplement standardized in proanthocyanidins|DIETARY_SUPPLEMENT: Placebo supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: BP-EASE -Effectiveness of Losartan 50 mg/Hydrochlorothiazide (HCTZ) 12.5 mg Versus Valsartan 80 mg/HCTZ 12.5 mg Titrated as Needed in Patients With Essential Hypertension Not Controlled on Monotherapy (0954A-333)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: losartan potassium (+) hydrochlorothiazide|DRUG: Comparator: Valsartan (+) Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Link Between Clinical and Physiological Sleep Data and Health-related Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Sleep Apnea Syndromes|Cardiovascular Diseases|Sleep Initiation and Maintenance Disorders|Nocturnal Myoclonus Syndrome|Hospitalizations|Mortality|Cancer
Interventions: OTHER: Sleep-related disturbances (exposure)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PfSPZ Challenge in Non-immune Adults in Baltimore, USA
Status: COMPLETED
Conditions: Plasmodium Falciparum Infection
Interventions: BIOLOGICAL: PfSPZ (7G8) Challenge|BIOLOGICAL: PfSPZ (NF54) Challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Operative Versus Non Operative Management Outcomes of Isolated Lateral Malleolar Weber B Ankle Fractures
Status: UNKNOWN
Conditions: Ankle Fractures
Interventions: PROCEDURE: ankle open reduction internal fixation|OTHER: non operative management
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Natural History With Its Numerous Co-morbidities?
Status: RECRUITING
Conditions: Postural Tachycardia Syndrome
Interventions: BEHAVIORAL: Looming task
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluate the Pharmacokinetics and Safety of MK-4448 in Participants With Nonvalvular Atrial Fibrillation or Atrial Flutter
Status: COMPLETED
Conditions: Atrial Fibrillation|Atrial Flutter
Interventions: DRUG: Amiodarone|DRUG: Betrixaban 60 mg|DRUG: Betrixaban 90 mg|DRUG: Betrixaban 30 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaginal Biorevitalization With Polydeoxyribonucleotides for the Improvement of the Genitourinary Syndrome of Menopause
Status: COMPLETED
Conditions: Genitourinary Syndrome of Menopause|Postmenopausal Disorder|Menopause|Vagina Atrophy
Interventions: DRUG: 3 g Polynucleotide vaginal suppositories|DRUG: Conjugated estrogens cream 1g Tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Patients With Multiple Myeloma That is Resistant to Current Standard of Care Treatments
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Linvoseltamab|DRUG: Daratumumab|DRUG: Carfilzomib|DRUG: Lenalidomide|DRUG: Bortezomib|DRUG: Pomalidomide|DRUG: Isatuximab|DRUG: Fianlimab|DRUG: Cemiplimab|DRUG: Nirogacestat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the PK and Safety of Single Doses of STS101, DHE Injection and Nasal Spray in Healthy Subjects
Status: COMPLETED
Conditions: Migraine|Migraine With Aura|Migraine Without Aura
Interventions: DRUG: Dihydroergotamine|DRUG: Dihydroergotamine|DRUG: Dihydroergotamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease
Status: COMPLETED
Conditions: Motor Neuron Disease|Amyotrophic Lateral Sclerosis|Primary Lateral Sclerosis|Progressive Muscular Atrophy
Interventions: BIOLOGICAL: Levetiracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Loncastixumab Tesirine (ADCT-402) Expanded Access Program (EAP) for Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Status: NO_LONGER_AVAILABLE
Conditions: Relapsed or Refractory Diffuse Large B-Cell Lymphoma (R/R DLBCL)
Interventions: BIOLOGICAL: Loncastuximab Tesirine
Study Type: EXPANDED_ACCESS
Clinical trial: The Effect of Two Different Methods Applied During Intramuscular Injection on the Level of Pain and Fear in Children
Status: COMPLETED
Conditions: Intramuscular Injection
Interventions: OTHER: Virtual reality glasses group|OTHER: Manual pressure group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Targeted Vessel Ablation of Type 3 Uterine Fibroids With Magnetic Resonance Guided High Intensity Focused Ultrasound
Status: TERMINATED
Conditions: Uterine Fibroid
Interventions: DEVICE: Magnetic Resonance guided High Intensity Focused Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of IC-Guided Feeding Protocol on Clinical Outcomes in Critically Ill Patients (The IC-Study)
Status: COMPLETED
Conditions: Critical Illness
Interventions: DIETARY_SUPPLEMENT: Enteral Nutrients ( Nutren Optimum, Nutren Diabetes, Novasource Renal ), Parenteral Nutrient ( Smofkabiven)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Groin Wound Infection Rate Using Prevena Compared to Standard Dressing in Vascular Surgery Patients With High Risk
Status: COMPLETED
Conditions: Endovascular Procedures
Interventions: OTHER: Prevena Dressing|OTHER: Conventional Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comprehensive HIV Prevention Package for South African Adolescent Girls and Young Women: IMARA SA
Status: COMPLETED
Conditions: Sexually Transmitted Infection|Hiv
Interventions: BEHAVIORAL: IMARA-SA (intervention group)|BEHAVIORAL: Health promotion control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: COPES Phase I Randomized Controlled Trial of Treatment For Distress in Heart Disease Patients
Status: COMPLETED
Conditions: Heart Diseases|Depression
Interventions: BEHAVIORAL: Enhanced depression care|BEHAVIORAL: Referred depression care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Study of Compression Devices Used in Transradial Coronary Angiography
Status: COMPLETED
Conditions: Peripheral Artery Occlusion|Hemostasis|Injury of Radial Artery
Interventions: DEVICE: RY-STOP hemostasis device|DEVICE: TR-Band, Terumo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE