pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Randomized Phase 2, Dose-finding Efficacy, Safety Study of ANF-RHO™ Versus Neulasta® in Chemotherapy-Induced Neutropenia
Status: TERMINATED
Conditions: Chemotherapy-induced Neutropenia
Interventions: DRUG: ANF-RHO™|DRUG: Neulasta®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VEC-162 Study in Healthy Adult Volunteers in a Model of Insomnia
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: 20 mg VEC-162|DRUG: 50 mg VEC-162|DRUG: 100 mg VEC-162|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Efficacy of Surgery Staging and Image Staging of Locally Advanced Cervical Cancer
Status: RECRUITING
Conditions: Locally Advanced Cervical Cancer
Interventions: RADIATION: Concurrent chemoradiation|PROCEDURE: Open/minimally invasive para-aortic lymph node dissection followed by concurrent chemoradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: Dupilumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Doses of MK-0941 in Type 2 Diabetics (MK-0941-027)
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: MK-0941|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AStudy To Evaluate Safety And Eficacy Of Apixaban In Japanese Acute Deep Vein Thrombosis (DVT) And Pulmonary Embolism (PE) Patients
Status: COMPLETED
Conditions: Deep Vein Thrombosis|Pulmonary Embolism
Interventions: DRUG: Apixaban|DRUG: Unfractionated Heparin (UFH)|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Effects of Intra-aortic Balloon Support in Early Acute Coronary Syndrome and Non-Acute Coronary Syndrome Related Cardiogenic Shock
Status: NOT_YET_RECRUITING
Conditions: Cardiogenic Shock
Interventions: DEVICE: Intra-Aortic Balloon Pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study in Pancreatic or Midgut Neuroendocrine Tumours Having Progressed Radiologically While Previously Treated With Lanreotide Autogel® 120 mg
Status: COMPLETED
Conditions: Pancreatic Tumours|Midgut Neuroendocrine Tumours
Interventions: DRUG: Lanreotide autogel 120 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison by Neuromonitoring of Two Techniques of Tracheal Intubation in Patients With Unstable Cervical Spine
Status: COMPLETED
Conditions: Spinal Injuries
Interventions: PROCEDURE: tracheal intubation|DEVICE: Airtraq|DEVICE: fiberscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Effect of AG-881 on the Pharmacokinetics of a Single Dose of Lamotrigine in Healthy Adults
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: AG-881|DRUG: Lamotrigine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: 8-week Study to Evaluate Safety and Efficacy of Various Combinations of Valsartan, HCTZ, and Amlodipine in Patients With Moderate to Severe Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Valsartan + amlodipine|DRUG: Valsartan + HCTZ|DRUG: Amlodipine + HCTZ|DRUG: Valsartan + amlodipine + HCTZ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: CTS2190 Phase I /II Clinical Study in Patients
Status: RECRUITING
Conditions: Solid Tumors|Pancreatic Cancer|Non-small Cell Lung Cancer|Triple-negative Breast Cancer
Interventions: DRUG: CTS2190 capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alectinib in Combination With Nivolumab in the Treatment of Recurrent or Refractory HCC Patients Guided With Serum RNase1 and Tumor Expression of PD-L1
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Alectinib (Alecensa), Nivolumab (Opdivo)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thyromental Height Test as a New Method for Prediction of Difficult Intubation in Obese Patients
Status: UNKNOWN
Conditions: Intubation, Intratracheal|Obesity|Predictive Value of Tests
Interventions: DIAGNOSTIC_TEST: Anthropometric measurements during routine preoperative visit|OTHER: Assesment of intubation parameters during induction of general anaesthesia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Patients With Pulmonary Hypertension or Interstitial Lung Disease at Altitude - Effect of Oxygen on Exercise Performance
Status: COMPLETED
Conditions: Precapillary Pulmonary Hypertension|Interstitial Lung Disease
Interventions: BEHAVIORAL: Moderate altitude sojourn|BEHAVIORAL: Low altitude sojourn|DRUG: Oxygen|DRUG: Sham oxygen (room air)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Prasugrel at PCI or Time of Diagnosis of Non-ST Elevation Myocardial Infarction
Status: COMPLETED
Conditions: Acute Coronary Syndromes
Interventions: DRUG: Placebo|DRUG: Prasugrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimize Audit and feedbaCk To Implement eVidence-based prAcTices in Primary Health carE
Status: NOT_YET_RECRUITING
Conditions: Hypertension|Diabetes
Interventions: BEHAVIORAL: Feedback provided face to face|BEHAVIORAL: Feedback provided by electronic mail|BEHAVIORAL: Feedback provided by researchers|BEHAVIORAL: Feedback provided by authoritative bodies|BEHAVIORAL: Feedback provided with peer comparision|BEHAVIORAL: Feedback provided without peer comparision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase II Study of Zidovudine and Recombinant Alpha-2A Interferon in the Treatment of Patients With AIDS-Associated Kaposi's Sarcoma
Status: COMPLETED
Conditions: Sarcoma, Kaposi|HIV Infections
Interventions: DRUG: Interferon alfa-2a|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Evaluation of Collagen Drink Products
Status: COMPLETED
Conditions: Skin Condition
Interventions: DIETARY_SUPPLEMENT: Placebo drink|DIETARY_SUPPLEMENT: MAXI Collagen drink|DIETARY_SUPPLEMENT: Normal fish collagen drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study Investigating the Predictive Value of Philadelphia Positive Stem Cell Properties in Newly Diagnosed Patients With Chronic Myeloid Leukemia in Chronic Phase Receiving Treatment With Imatinib
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia
Interventions: PROCEDURE: Stem Cell and Mutational Assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: COaching and Prehabilitation: Faisability Study in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: PROCEDURE: Coaching and Habilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Smart VR Mindfulness for Breast Cancer: Integrating Biofeedback and Evaluating Chemotherapy Effectiveness
Status: RECRUITING
Conditions: Breast Cancer|Chemotherapy|Virtual Reality|Mindfulness
Interventions: BEHAVIORAL: mindfulness based virtual reality|BEHAVIORAL: mindfulness based audio practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sequential Therapy With Tacrolimus and Rituximab in Primary Membranous Nephropathy
Status: COMPLETED
Conditions: MEMBRANOUS NEPHROPATHY
Interventions: DRUG: TACROLIMUS|DRUG: RITUXIMAB|DRUG: METHYLPREDNISOLONE|DRUG: CYCLOPHOSPHAMIDE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Folate Levels in Women Taking Oral Contraceptives
Status: WITHDRAWN
Conditions: Neural Tube Defects|Congenital, Hereditary, and Neonatal Diseases and Abnormalities|Nervous System Malformations
Interventions: DRUG: Norgestimate-ethinyl estradiol, with or without folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Progression-free Survival After MWA Plus Durvalumab and Tremelimumab for Unresectable Locally Advanced Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer Non-resectable
Interventions: DRUG: Durvalumab 50 MG/ML|DRUG: Tremelimumab|DRUG: Gemcitabine|PROCEDURE: Minimally Invasive Surgical Microwave Ablation (MIS-MWA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Pharmacokinetics Profile of MT101-5 in Healthy Volunteers
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: MT101-5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of Escalating Doses of Itacitinib Administered Orally in Patients With Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Itacitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Cognitive Behavioral Therapy for Treating Depression in People With Bipolar I Disorder
Status: COMPLETED
Conditions: Bipolar Disorder|Depression
Interventions: OTHER: Supportive Psychotherapy|OTHER: Cognitive Behavioral Therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Combination Therapy With Cetuximab and FOLFOX4 in Patients With Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: FOLFOX-4+cetuximab|DRUG: FOLFOX-4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VR-PAT and fNIRS to Identify CNS Biomarkers of Pain
Status: NOT_YET_RECRUITING
Conditions: Acute Pain|Pediatric ALL|Procedural Pain|Burns
Interventions: OTHER: VR-PAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy, Immunogenicity, and Safety of a Single Dose of V710 in Adult Patients Scheduled for Cardiothoracic Surgery (V710-003 AM2)
Status: TERMINATED
Conditions: Staphylococcus Aureus|Bacteremia|Mediastinitis
Interventions: BIOLOGICAL: V710|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Risk of Dry Eye Post Different Surgeries for Blepharoptosis Repair
Status: UNKNOWN
Conditions: Blepharoptosis
Interventions: PROCEDURE: Levator advancement|PROCEDURE: Müller's muscle-conjunctival resection procedure|PROCEDURE: White line advancement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: rVWF IN PROPHYLAXIS
Status: COMPLETED
Conditions: Von Willebrand Disease
Interventions: BIOLOGICAL: von Willebrand factor (Recombinant)|BIOLOGICAL: Antihemophilic Factor (Recombinant)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: COVID Protection After Transplant - Sanofi GSK (CPAT-SG) Study
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19|Kidney Transplant
Interventions: BIOLOGICAL: Sanofi-GSK monovalent (B.1.351) CoV2 preS dTM-AS03 COVID-19 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Zinc Supplements in Lowering Cadmium Levels in Smokers
Status: COMPLETED
Conditions: Bladder Cancer|Cervical Cancer|Esophageal Cancer|Gastric Cancer|Head and Neck Cancer|Kidney Cancer|Leukemia|Liver Cancer|Lung Cancer|Pancreatic Cancer|Tobacco Use Disorder
Interventions: DIETARY_SUPPLEMENT: zinc oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study Evaluating the Pharmacokinetics and Relative Bioavailability of Emraclidine Immediate-Release Tablets in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Treatment A: Emraclidine 30mg IR tablets (reference)|DRUG: Treatment B: Emraclidine 30mg IR test tablets 1|DRUG: Treatment C: Emraclidine 30mg IR test tablets 2|DRUG: Treatment D: Emraclidine 30mg IR test tablets 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 4 Trial to Evaluate the Efficacy and Safety of Sancuso Patch in CINV (Chemotherapy-induced Nausea and Vomiting) Associated With the Administration of MEC (Moderately Emetogenic Chemotherapy)
Status: UNKNOWN
Conditions: Chemotherapy-induced Acute or Delayed Nausea and Vomiting (CINV)
Interventions: DRUG: Sancuso patch|DRUG: Kytril inj.+Kytril tab.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Lullaby Records Sung By The Parent's During Newborn Care On Newborn's
Status: COMPLETED
Conditions: Comforf, Procedural (During Newborn Care İn Newborn's)|Physiological Parameters During Newborn Care İn Newborn's
Interventions: BEHAVIORAL: LISTENING TO THE RECORDINGS SAYING BY PARENTS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dalteparin Versus Unfractionated Heparin In Patients With Acute Coronary Syndrome
Status: TERMINATED
Conditions: Angina, Unstable|Myocardial Infarction
Interventions: DRUG: Dalteparin ( Fragmin)|DRUG: Unfractionated heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smoking Cessation And Reduction in Depression
Status: UNKNOWN
Conditions: Tobacco Smoking in Depressed Patients
Interventions: DEVICE: Ecig 24 mg nicotine|DEVICE: Ecig 0 mg nicotine|DEVICE: Nicotine free inhalator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis
Status: COMPLETED
Conditions: Anterior Uveitis|Panuveitis
Interventions: DRUG: Difluprednate Ophthalmic Emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Ferric Derisomaltose and Outcomes in the Recovery of Gynecologic Oncology: ERAS (Enhanced Recovery After Surgery)
Status: NOT_YET_RECRUITING
Conditions: Gynecologic Cancer|Anemia|Iron-deficiency
Interventions: DRUG: Ferric derisomaltose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Tolerability of Botox and Topiramate or Botox and Placebo and Effect on Cognitive Efficiency
Status: COMPLETED
Conditions: Chronic Migraine
Interventions: DRUG: onabotulinumtoxinA|DRUG: Topiramate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Participants With Advanced Melanoma (MK-3475-002/P08719/KEYNOTE-002)
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Dacarbazine|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Amoxicillin Compared With Placebo for Pneumonia in Children Aged 2-59 Months
Status: COMPLETED
Conditions: Acute Respiratory Infections|Pneumonia
Interventions: DRUG: Amoxicillin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AZD3293 Thorough QT Study in Healthy Male Volunteers
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: AZD3293|DRUG: AZD3293|DRUG: Placebo|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: HCQ+ADC vs ADC in the Treatment of Advanced Breast Cancer
Status: RECRUITING
Conditions: Advanced Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: Hydroxychloroquine|DRUG: Sacituzumab Govitecan|DRUG: Trastuzumab Deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Ketogenic Diet on Glucose Metabolism and Energy Expenditure in Type 2 Diabetes
Status: COMPLETED
Conditions: Glucose Metabolism Disorders (Including Diabetes Mellitus)|Energy Supply; Deficiency|Type 2 Diabetes
Interventions: OTHER: Standard weight maintaining diet|OTHER: Weight maintaining isocaloric ketogenic diet|DIETARY_SUPPLEMENT: Beta-hydroxy butyrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Microfragmented Adipose Tissue Versus Platelet-rich Plasma for Knee Osteoarthritis: a Randomized Comparative Trial
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Microfragmented Adipose Tissue|Platelet-Rich Plasma
Interventions: DEVICE: Platelet Rich Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of the WHO 8-step Wheelchair Service Delivery Process on Wheelchair Users in El Salvador: a Cohort Study
Status: COMPLETED
Conditions: Wheelchair Users
Interventions: OTHER: The World Health Organization 8 steps for manual wheelchair service delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Post-COntrast 3D SE T1 Versus Coronal SE T1-WI MRI in Detecting Optic Neuritis (COCON)
Status: COMPLETED
Conditions: Optic Neuritis|Multiple Sclerosis
Interventions: DIAGNOSTIC_TEST: Magnetic Resonance Imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chiropractic Management of Chronic Lower Back Pain in Older Adults
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: PROCEDURE: Spinal Manipulation|PROCEDURE: Detuned Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety and Efficacy of Upadacitinib in Adults With Active Ankylosing Spondylitis
Status: COMPLETED
Conditions: Ankylosing Spondylitis (AS)
Interventions: DRUG: Upadacitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Mechanistic Demonstration of a Bioelectric Dressing System for Non-healing Wound Management: A Phase II Trial
Status: TERMINATED
Conditions: Non-healing Soft Tissue Wounds
Interventions: DRUG: Procellera
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Cerebellar TMS on Brain and Cognitive Functions in Schizophrenia: a Pilot Study
Status: RECRUITING
Conditions: Schizophrenia|Cerebellar Function|Condition
Interventions: DEVICE: Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Afatinib and Postoperative Radiation Therapy to Treat Head and Neck Cancer
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Afatinib|DRUG: Docetaxel|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Ultra-low-dose Chest CT With AI Based Denoising Solution
Status: UNKNOWN
Conditions: Lung Diseases
Interventions: RADIATION: Low radiation dose CT|RADIATION: Underwent ultra dose chest CT|OTHER: Artificial Intelligence based model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Ghrelin on Glucose Metabolism After Bariatric Surgery
Status: COMPLETED
Conditions: Obesity
Interventions: PROCEDURE: Oral Glucose Tolerance Test (OGTT)|DRUG: Human Ghrelin|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Robotic Gait Rehabilitation in Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease|Gait Disorder, Sensorimotor
Interventions: DEVICE: G-EO End-Effector Gait Trainer|OTHER: Conventional Physical Therapy Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Addressing HyperteNsion and Diabetes Through Community-Engaged Systems in Puno, Peru (ANDES Study)
Status: RECRUITING
Conditions: Hypertension|Diabetes
Interventions: BEHAVIORAL: ANDES INTERVENTION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of High Intensity Laser Versus Plus Exercises
Status: COMPLETED
Conditions: Effect of High Intensity Laser Plus Exercises on Wrist Pain
Interventions: OTHER: high intensity laser plus exercise|DEVICE: high intensity laser only|OTHER: exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dental Plaque Removal Study
Status: COMPLETED
Conditions: Gingivitis|Gum Disease
Interventions: OTHER: Manual Toothbrush only|OTHER: MTB + Waterpik Ultra Water Flosser 'High'|OTHER: MTB + Floss (MTB+Floss)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of Bone Mineral Density in People Living With HIV and KSHV Associated Malignancies: A Retrospective Longitudinal Analysis
Status: ACTIVE_NOT_RECRUITING
Conditions: Kaposi Sarcoma|KSHV Associated Multicentric Castleman Disease|Primary Effusion Lymphoma|IL-6 Related KSHV Associated Cytokine Syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Development and Validation of a Self-assessment System Based on a Mobile App to Manage Adult Growth Hormone Deficiency
Status: ACTIVE_NOT_RECRUITING
Conditions: Growth Hormone Deficiency
Interventions: OTHER: Use of "MAGHD App/MAGHD Framework"
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase II Trial of Calcitriol and Naproxen in Patients With Recurrent Prostate Cancer
Status: TERMINATED
Conditions: Prostatic Neoplasms|Prostate Cancer
Interventions: DRUG: Calcitriol|DRUG: Naproxen-n-butyl nitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment of Two Daily Wear Reusable Soft Silicone Hydrogel Contact Lenses
Status: COMPLETED
Conditions: Refractive Errors
Interventions: DEVICE: Lehfilcon A contact lenses|DEVICE: Senofilcon A contact lenses|DEVICE: AOSEPT PLUS with HydraGlyde
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of TQ-B3101 in Subjects With Relapsed or Refractory Anaplastic Large Cell Lymphoma (ALCL)
Status: UNKNOWN
Conditions: Relapsed/Refractory Anaplastic Large Cell Lymphoma (ALCL)
Interventions: DRUG: TQ-B3101 capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sulodexide, VESSEL®, for the Prevention of Recurrent Venous Thromboembolism (The Jason Study)
Status: RECRUITING
Conditions: Venous Thromboembolism|Anticoagulant|Elderly
Interventions: DRUG: Sulodexide|DRUG: Sulodexide and placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors
Status: RECRUITING
Conditions: Central Nervous System Neoplasms|Atypical Teratoid/Rhabdoid Tumor|Diffuse Midline Glioma, H3 K27M-Mutant|Ependymoma|High Grade Glioma|Glioblastoma|Medulloblastoma
Interventions: DRUG: B7-H3-CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic and Respiratory Outcomes in Patients Receiving Continuous Bilateral Erector Spinae Plane Block Compared to Continuous Preperitoneal Catheter Wound Infusion After Upper Abdominal Surgery
Status: UNKNOWN
Conditions: Abdominal Cancer Surgery
Interventions: PROCEDURE: Erector Spinae Plane block|PROCEDURE: Continuous Wound Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Lumbar PENS and Exercise in Older Adults With Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Lumbar PENS + General Conditioning and Aerobic Exercise|OTHER: Lumbar PENS|OTHER: Control Lumbar PENS|OTHER: Control PENS + exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pain Medication in Children With Acute Abdominal Pain and Its Implication Over the Surgeon's Decision
Status: WITHDRAWN
Conditions: Abdominal Pain
Interventions: DRUG: Morphine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy of ARA 290 on Corneal Nerve Fiber Density and Neuropathic Symptoms of Subjects With Sarcoidosis
Status: COMPLETED
Conditions: Neuropathy of Sarcoidosis
Interventions: DRUG: ARA 290|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Followed by Radiation Therapy and Peripheral Stem Cell Transplant Compared With Chemotherapy Plus Interferon Alfa in Treating Patients With Stage III or Stage IV Mantle Cell Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: recombinant interferon alfa|DRUG: carmustine|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: dexamethasone|DRUG: etoposide|DRUG: melphalan|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: DAVID II (Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial II)
Status: COMPLETED
Conditions: Ventricular Tachycardia|Ventricular Fibrillation|Sudden Cardiac Death|Congestive Heart Failure
Interventions: DEVICE: Implantable Defibrillator (ICD)|DEVICE: Implantable Defibrillator (ICD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Essential Thrombocythemia|Myelodysplastic Syndrome|Myelodysplastic/Myeloproliferative Neoplasm|Myeloproliferative Neoplasm|Myeloproliferative Neoplasm, Unclassifiable|Polycythemia Vera|Primary Myelofibrosis|Secondary Myelofibrosis
Interventions: DRUG: Decitabine|DRUG: Ruxolitinib|DRUG: Fedratinib|OTHER: Questionnaire Administration|DRUG: Pacritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Ciclesonide Nasal Spray in Patients With Perennial Allergic Rhinitis (2-5 Years Old) (BY9010/M1-416)
Status: COMPLETED
Conditions: Hay Fever|Perennial Allergic Rhinitis
Interventions: DRUG: Ciclesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Trial of Pomalidomide and Dexamethasone in Subjects With Previously-Treated AL Amyloidosis
Status: COMPLETED
Conditions: AL Amyloidosis
Interventions: DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amplifying Graft-Versus-Tumor Effect by Donor Regulatory T-Cell Depletion Before Donor Lymphocytes Infusion
Status: COMPLETED
Conditions: Hematologic Neoplasms|Relapse
Interventions: PROCEDURE: donor lymphocyte infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of Anti Nausea Medication With and Without Food (EUR-1025)
Status: COMPLETED
Conditions: Nausea
Interventions: DRUG: Ondansetron|DRUG: Ondansetron
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Escalation Safety and Pharmacokinetic Study of Iso-Fludelone in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Iso-Fludelone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Exercise Training Under HFO Device on Endurance Tolerance in Patients With COPD and CRF: a Randomized Controlled Study.
Status: COMPLETED
Conditions: COPD
Interventions: DEVICE: HFO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: Study Evaluating the Safety of Rovalpituzumab Tesirine for Third-Line and Later Treatment of Subjects With Relapsed or Refractory Small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Dexamethasone|DRUG: Rovalpituzumab tesirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total Thyroidectomy With and Without Prophylactic Central Neck Lymph Node Dissection in People With Low-risk Papillary Thyroid Cancer
Status: TERMINATED
Conditions: Low-risk Papillary Thyroid Cancer|Endocrine Malignancy|Thyroid Cancer
Interventions: PROCEDURE: Total Thyroidectomy (TT)|PROCEDURE: Prophylactic central neck lymph node dissection (pCND)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Drug Interaction Study Between Raltegravir and Atorvastatin.
Status: COMPLETED
Conditions: HIV|Hypercholesterolaemia
Interventions: DRUG: raltegravir|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Ganglion Sphenopalatine Block (GSP-block) Follow-Up
Status: COMPLETED
Conditions: Post-Dural Puncture Headache|Ganglion Sphenopalatine Block
Interventions: PROCEDURE: Ganglion Sphenopalatine Block
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Paclitaxel and Carboplatin Chemotherapy Compared With Standard Chemotherapy in Treating Patients With Stage III or Stage IV Non-small Cell Lung Cancer That Cannot Be Removed During Surgery
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: cisplatin|DRUG: ifosfamide|DRUG: mitomycin C|DRUG: paclitaxel|DRUG: vinblastine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study Between Fluticasone Propionate 100 mcg/Blister Oral Inhalation Powder/Respirent Pharmaceuticals vs. FLOVENT DISKUS® 100 mcg/Blister Oral Inhalation Powder /GSK in Healthy Volunteers Under Fasting Conditions
Status: UNKNOWN
Conditions: Asthma|Bioequivalence
Interventions: DRUG: Fluticasone Propionate 100 mcg/Blister Oral Inhalation Powder/Respirent Pharmaceuticals|DRUG: FLOVENT DISKUS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Assess the Effect of Timing of Food Intake on the Pharmacokinetics of Abiraterone Following Single-Dose Administration of Abiraterone Acetate Tablets in Healthy Caucasian and Japanese Men
Status: COMPLETED
Conditions: Pharmacology
Interventions: DRUG: Abiraterone: Treatment A|DRUG: Abiraterone: Treatment B|DRUG: Abiraterone: Treatment C|DRUG: Abiraterone: Treatment D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Two Distraction Methods on the Level of Pain, Fear and Anxiety in Children
Status: COMPLETED
Conditions: Pain|Anxiety|Fear|Venipuncture Site Reaction|Nursing Caries
Interventions: BEHAVIORAL: Virtual reality|DEVICE: Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Duration of Antibiotic Therapy in Community - Acquired Pneumonia
Status: UNKNOWN
Conditions: Pneumonia|Bronchopneumonia|Pleuropneumonia|Pneumonia, Bacterial|Pneumonia, Viral
Interventions: OTHER: Discontinuation of antibiotic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment Of The Effect Of Pelvic Floor Dysfunction Related Temporamandibular Joint Problems On Tinnitus
Status: UNKNOWN
Conditions: Tinnitus|Temporomandibular Joint Disorders|Pelvic Floor Disorders
Interventions: BEHAVIORAL: Questionnaires and Rehabilitation Programs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of an Enhanced Sterile Protocol on Root Canal Treatment Outcome
Status: UNKNOWN
Conditions: Endodontic Disease|Root Canal Treatment|Root Canal Infection
Interventions: PROCEDURE: Access cavity preparation|PROCEDURE: Working Length Determination|PROCEDURE: Root canal instrumentation and chemo-mechanical preparation|PROCEDURE: Root canal obturation|PROCEDURE: Coronal restoration build up|OTHER: Changing gloves before obturation|OTHER: Disinfecting rubber dam|OTHER: The use of new instruments at time of obturation|RADIATION: Cone Beam Computed Tomography scanning (CBCT)|RADIATION: Radiographic imaging using periapical radiographs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Beclomethasone Dipropionate 100 µg + Formoterol 6 µg pMDI Via HFA-134a Vs. Budesonide 160 µg + Formoterol 4,5 µg Dry Powder Via Turbuhaler®. (Symbicort®)
Status: COMPLETED
Conditions: Bronchial Asthma
Interventions: DRUG: beclomethasone dipropionate plus formoterol fumarate combination|DRUG: budesonide plus formoterol combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sexual and Gender Minority Youth (SGMY) and Online Interventions to Increase Help-seeking for Anxiety and/or Depression
Status: COMPLETED
Conditions: Anxiety|Depression|Adolescent Behavior|Sexual and Gender Minorities
Interventions: BEHAVIORAL: Intersectionality and Identity|BEHAVIORAL: Confidentiality|BEHAVIORAL: Educating Your Community|BEHAVIORAL: How to find Affirming Caregivers|BEHAVIORAL: Control Group - No Interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluating Monitoring Techniques for Postoperative Spinal Cord Ischemia
Status: RECRUITING
Conditions: Monitoring|Postoperative|Spinal Cord Ischemia|Thoracoabdominal Aneurysm|TAAA|NIRS|Long Loop Reflexes|F-waves
Interventions: DEVICE: Near-infrared spectroscopy|DEVICE: Long loop reflex measurements
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Influence of Genotype of CYP2C9 on Clinical Efficacy and Pharmacokinetics of Piroxicam After Lower Third Molar Surgery
Status: COMPLETED
Conditions: Pain|Other Surgical Procedures|Impacted Third Molar Tooth|Cytochrome P450 CYP2C9 Enzyme Deficiency
Interventions: DRUG: Piroxicam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Tolerability of E5555 and Its Effects on Markers of Intravascular Inflammation in Subjects With Acute Coronary Syndrome
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: E5555|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effectiveness of the Initial Specimen Diversion Device
Status: COMPLETED
Conditions: Septicemia
Interventions: DEVICE: Initial Specimen Diversion Device (ISDD)|DEVICE: Lab standard practice (LSP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Endovascular Aneurysm Repair (EVAR) Gate Study
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm (AAA)
Interventions: PROCEDURE: Endovascular Aneurysm Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Dobutamine Versus Milrinone in Management of Critically Ill Low Cardiac Output Pediatric Patients at Cairo University Children's Hospital
Status: NOT_YET_RECRUITING
Conditions: Dobutamine, Milrinone , Pediatrics , Low Cardiac Output
Interventions: DRUG: Dobutamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity
Status: COMPLETED
Conditions: Metabolism and Nutrition Disorder|Obesity
Interventions: DRUG: Semaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Promotion of Successful Parenting
Status: ACTIVE_NOT_RECRUITING
Conditions: Pregnant and Parenting Women
Interventions: BEHAVIORAL: Child-Parent Psychotherapy (CPP)|BEHAVIORAL: Community Health Worker (CHW) home visitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of SHR-A1811 Monotherapy or Combined With Pyrotinib Maleate as Neoadjuvant Treatment in HER2-positive Breast Cancer Patients
Status: RECRUITING
Conditions: HER2-positive Breast Cancer
Interventions: DRUG: SHR-A1811|DRUG: Pyrotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects in The ApoB/ApoA-I Ratio Using Rosuvastatin and Atorvastatin in Patients With Acute Coronary Syndrome
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Rosuvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Feasibility of a Digital Health Coaching Program for Individuals Following CAR T Therapy
Status: COMPLETED
Conditions: Lymphoma|Lymphoma, B-Cell|Leukemia|Multiple Myeloma|Mantle Cell Lymphoma|Follicular Lymphoma|Leukemia, Acute Lymphoblastic
Interventions: BEHAVIORAL: Digital Health Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial to Evaluate BMS-298585 as Monotherapy in Subjects With Type 2 Diabetes Who Have Inadequate Glycemic Control
Status: COMPLETED
Conditions: Diabetes, Type 2
Interventions: DRUG: Muraglitazar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Topic Antiinflammatory Therapy Added to Selective Photocoagulation in Macular Edema
Status: COMPLETED
Conditions: Diabetic Retinopathy|Macular Edema
Interventions: DRUG: Ketorolac|DRUG: Nepafenac|DRUG: Polietilenglicol 400, propilenglicol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Food as Medicine: Evaluating the Impact of Home-delivered Vegetables and Whole Grains on Diet of Food-insecure Families
Status: COMPLETED
Conditions: Food Insecurity|Nutrition Poor
Interventions: BEHAVIORAL: Food as Medicine Delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACOART Paclitaxel SVD:Paclitaxel Coated Coronary Balloon Catheter in Treatment of Coronary Small Vessel Diseases
Status: RECRUITING
Conditions: Coronary Disease
Interventions: DEVICE: test DCB|DEVICE: RESTORE DCB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dual Chamber Versus Single Chamber Cardiac Pacing in People 80 Years of Age and Older
Status: TERMINATED
Conditions: Atrial Fibrillation|Cardiac Pacing, Artificial
Interventions: DEVICE: Dual chamber cardiac pacemaker|DEVICE: Single chamber cardiac pacemaker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Tolerability of AZD5213 Effect on Sleep for Patients With Alzheimer's/Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Mild Alzheimer's Disease
Interventions: DRUG: AZD5213|DRUG: AZD5213|DRUG: AZD5213|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Assess the Effect of Long Term Dosing of Inclisiran in Subjects With High CV Risk and Elevated LDL-C
Status: COMPLETED
Conditions: ASCVD|Elevated Cholesterol|Heterozygous Familial Hypercholesterolemia|Homozygous Familial Hypercholesterolemia
Interventions: DRUG: Inclisiran Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD2 Lozenges in Preventing Acute Oral Mucositis in Patients With Head and Neck Cancer Receiving Radiotherapy and Chemotherapy
Status: WITHDRAWN
Conditions: Head and Neck Cancer|Oral Complications of Radiation Therapy|Pain|Weight Changes
Interventions: DIETARY_SUPPLEMENT: Lactobacillus brevis CD2 lozenge|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE