pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: 24-hour Lung Function in Subjects With Moderate to Very Severe COPD After Treatment With PT003, Open-Label Spiriva® Respimat® as an Active Control, and Placebo
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: GFF MDI (PT003)|DRUG: Placebo MDI|DRUG: Spiriva® Respimat® (Tiotropium Bromide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation to Assess a New Artificial Urinary Sphincter to Treat Urinary Incontinence in Men
Status: ACTIVE_NOT_RECRUITING
Conditions: Urinary Incontinence,Stress
Interventions: DEVICE: UroMems artificial urinary sphincter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Toxicity of Blinatumomab in the French ATU for Adult BCP-ALL R/R, or With MRD+ (FRENCH-CYTO)
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia, in Relapse|Acute Lymphoblastic Leukemia With Failed Remission
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Novel Magnetic Resonance Imaging-Guided Ultrasound-Stimulated Microbubble Radiation Treatment for Patients With Chest-Wall and Locally Advanced Breast Cancer-Phase II
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Definity|DEVICE: Sonalleve Focused Ultrasound Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Vitamin D and Fish Oil on the Kidney in Hypertensives
Status: COMPLETED
Conditions: Hypertension|Kidney Diseases
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DRUG: Omega-3 Fatty acids|DIETARY_SUPPLEMENT: Vitamin D3 placebo|DIETARY_SUPPLEMENT: Fish oil placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Social Cognition and Interaction Training for Autism
Status: COMPLETED
Conditions: Autism|Social Behavior
Interventions: BEHAVIORAL: Social Cognition and Interaction Training for Autism (SCIT-A)|OTHER: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Coherent Breathing on Elderly Quality of Life
Status: COMPLETED
Conditions: Stable Diabetes Mellitus|Geriatrics|Hypertension
Interventions: OTHER: Coherent Breathing Exercise|DEVICE: Inspiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Tocilizumab Plus Methotrexate on Safety and Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tocilizumab [RoActemra/Actemra]|DRUG: methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhibition of Plasma Kallikrein as a New Therapy for Lung Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Injury
Interventions: DRUG: Lanadelumab|OTHER: Saline control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Fianlimab in Combination With Cemiplimab Versus Pembrolizumab in Adolescent and Adult Patients With Previously Untreated Unresectable Locally Advanced or Metastatic Melanoma
Status: RECRUITING
Conditions: Melanoma
Interventions: DRUG: Fianlimab|DRUG: Cemiplimab|DRUG: Pembrolizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation (FMT) in Nonalcoholic Steatohepatitis(NASH). A Pilot Study
Status: UNKNOWN
Conditions: Nonalcoholic Fatty Liver Disease
Interventions: DRUG: Fecal Microbiota Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation in Poor Responders
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: dehydroepiandrosterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Reminiscence Therapy Versus Cognitive Stimulation in Older Adults With Cognitive Decline
Status: COMPLETED
Conditions: Cognitive Decline
Interventions: BEHAVIORAL: Group intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preoperative Gefitinib for EGFR Mutant II-IIIa NSCLC (ECTOP-1001)
Status: COMPLETED
Conditions: Non-small-cell Lung Cancer
Interventions: DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Microcirculation and Inflammation After Minimal-invasive Osteosynthesis of the Proximal Femur
Status: COMPLETED
Conditions: Level of Pain
Interventions: PROCEDURE: PCCP|PROCEDURE: DHS|PROCEDURE: Osteosynthesis with nails
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study for Efficacy and Safety of Live Biotherapeutic MRx4DP0004 to Treat COVID-19
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: MRx-4DP0004|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CircaHealth Development and Evaluation
Status: COMPLETED
Conditions: Health Behavior|Health Knowledge, Attitudes, Practice|Circadian Rhythm
Interventions: OTHER: CircaHealth: a course on circadian rhythms and health|OTHER: Sleep hygiene materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Bracing in Preventing Scoliosis in Children With Spinal Cord Injury
Status: UNKNOWN
Conditions: Scoliosis
Interventions: DEVICE: Thoraco-Lumbar-Sacral-Orthoses (TLSO) / Flex-Foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial for Azvudine in the Treatment of Novel Coronavirus Pneumonia (COVID-19）
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: FNC+Standard of Care|DRUG: FNC dummy tablet+Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating Accelerated Learning and Memory in Healthy Subjects Using a Face Name Memory Task
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DEVICE: tDCS|DEVICE: sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety, Tolerability, and Pharmacokinetics Study of NDX-1017
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: NDX-1017|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of CRS-207 With Pembrolizumab in Previously Treated Malignant Pleural Mesothelioma (MPM)
Status: TERMINATED
Conditions: Malignant Pleural Mesothelioma
Interventions: BIOLOGICAL: CRS-207|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vinegar-induced Collection of Duodenal Pancreatic Juice Via Endoscopic Ultrasound
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Vinegar 20ml|DRUG: Saline|DRUG: Vinegar 40ml|DRUG: Vinegar 20ml, 3 phases
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Trial Comparing Standard Care Versus Prehabilitation in Patients Undergoing Cancer Surgery
Status: COMPLETED
Conditions: Cancer of Colon|Cancer of Rectum|Liver Metastases
Interventions: OTHER: Prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Novel Combination Therapy for Osteoporosis in Men
Status: ACTIVE_NOT_RECRUITING
Conditions: Male Osteoporosis
Interventions: DRUG: Teriparatide or human parathyroid hormone (PTH) 1-34|DRUG: Cinacalcet|DRUG: placebo tablet|DIETARY_SUPPLEMENT: Calcium citrate tablet|DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optical Imaging Measurement of Intravascular Solution Efficacy Trial
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: PROCEDURE: Contrast Injection|PROCEDURE: Dextran Injection|PROCEDURE: CO2 Injection|PROCEDURE: Heparinized Normal Saline Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Restoring Motor and Sensory Hand Function in Tetraplegia Using a Neural Bypass System
Status: RECRUITING
Conditions: Spinal Cord Injuries|Spinal Cord Injury Cervical
Interventions: DEVICE: Bidirectional Neural Bypass System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thrombectomy REvascularization of Large Vessel Occlusions in Acute Ischemic Stroke (TREVO)
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: PROCEDURE: Mechanical Thrombectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of KETOgenic Diet on Metabolism, Inflammation, Nutrition Deficiencies and OXidative Stress in Women With Overweight
Status: ACTIVE_NOT_RECRUITING
Conditions: Overweight and Obesity
Interventions: OTHER: Ketogenic diet|OTHER: Control diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study in Healthy Japanese Men to Test How Different Doses of BI 690517 Are Taken up in the Body and How Well They Are Tolerated
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 690517|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Two Formulations of Pregabalin CR (Controlled-release) Table 150 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLA5PR GLARS-NF3 tablet 150mg|DRUG: GLA5PR GLARS-NF1 tablet 150mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of DS-1001b in Patients With Chemotherapy- and Radiotherapy-Naive IDH1 Mutated WHO Grade II Glioma
Status: ACTIVE_NOT_RECRUITING
Conditions: WHO Grade II Glioma
Interventions: DRUG: DS-1001b
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Possible Effects of Roflumilast on Obesity Related Disorders
Status: COMPLETED
Conditions: Obesity|PreDiabetes
Interventions: DRUG: Roflumilast|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Antidepressants or Antipsychotics in Preventing Psychosis
Status: WITHDRAWN
Conditions: Psychotic Disorder
Interventions: DRUG: Antidepressant|DRUG: Antipsychotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficiency of Propranolol as an Initial Treatment for Pediatric Hemangioma
Status: COMPLETED
Conditions: Hemangioma
Interventions: DRUG: Prednisolone|DRUG: Propranolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) Plus Ribavirin in Hemophiliac Patients With Chronic Hepatitis C.
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: peginterferon alfa-2a [Pegasys]|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TKR Rehabilitation Through the Immersive Virtual Reality in Aquatic Scenarios
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Osteoarthritis|Total Knee Replacement
Interventions: DEVICE: Experimental: Immersive Virtual Reality (HIVR)|PROCEDURE: Traditional Hydrotherapy (TH)|PROCEDURE: Traditional Rehabilitation (TR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Sphenopalatine Ganglion Block for Post-dural Puncture Headache
Status: UNKNOWN
Conditions: Post-Dural Puncture Headache
Interventions: PROCEDURE: Sphenopalatine ganglion block
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Descemet Endothelial Thickness Comparison Trial II
Status: RECRUITING
Conditions: Fuchs|Fuchs Dystrophy|Fuchs' Endothelial Dystrophy
Interventions: DRUG: Ripasudil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Satisfaction Vertical Ramus Osteotomy Patient Specificosteosynthesis Fixation Versus MMFmandibular Prognanthism
Status: UNKNOWN
Conditions: Mandibular Prognathism
Interventions: PROCEDURE: customized fixation plate|PROCEDURE: maxillomandibular fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Novel Edible Gel-based Artificial Saliva in Thai Geriatric Populations With Systemic Diseases
Status: COMPLETED
Conditions: Xerostomia|Hypertension|Diabetes Mellitus
Interventions: OTHER: Gel-based artificial saliva
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Retrospective Study of Prescribed Physical Activity in Patients With Overactive Bladder Syndrome Monitored Within the Pelvi-perineology Network in Dijon: Evaluation of Prescription Compliance and Impact on Quality of Life
Status: UNKNOWN
Conditions: iOAB= Idiopathic Overactive Bladder
Interventions: OTHER: Physical activity|OTHER: Absence of or suspended physical activity
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Strategy to Avoid Excessive Oxygen in Major Burn Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Critical Illness|Wounds and Injury|Disease Attributes|Pathologic Processes
Interventions: OTHER: Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Cordyceps Sinensis Mycelium Culture Extract(Paecilomyces Hepiali, CBG-CS-2) on Promotion of Immunity
Status: COMPLETED
Conditions: Immunity
Interventions: DIETARY_SUPPLEMENT: Cordyceps sinensis mycelium culture extract 0.76 g|DIETARY_SUPPLEMENT: Cordyceps sinensis mycelium culture extract 1.15 g|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Prasugrel Versus High Dose Clopidogrel in Patients With Stable Coronary Artery Disease and High Platelet Reactivity While on Chronic Clopidogrel Treatment
Status: COMPLETED
Conditions: Coronary Artery Disease (CAD)
Interventions: DRUG: Prasugrel|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of HDM201 in Combination With LEE011 in Patients With Liposarcoma
Status: COMPLETED
Conditions: Liposarcoma
Interventions: DRUG: HDM201|DRUG: LEE011
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest of Tumor Replicates in Avian Embryo to Model Therapeutic Effects of BRAFi/MEKi in BRAF Mutated Melanoma
Status: RECRUITING
Conditions: Melanoma
Interventions: PROCEDURE: Skin biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety Study of Varying Doses of Lanreotide Autogel in Patients With Acromegaly
Status: COMPLETED
Conditions: Acromegaly
Interventions: DRUG: Lanreotide (Autogel formulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Germline Mutations in Patients With Head and Neck Cancer and a Family History of Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: GENETIC: gene expression analysis|GENETIC: mutation analysis|GENETIC: polymerase chain reaction|GENETIC: polymorphism analysis|OTHER: flow cytometry|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility of Aggressive Albuminuria Reduction in Biopsy-Proven Diabetic Nephropathy - A Pilot Study
Status: RECRUITING
Conditions: Diabetic Kidney Disease
Interventions: DRUG: ACEi / ARB, SGLT2i, finerenone, semaglutide, pentoxifylline, hydrochlorthiazide, baricitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of Safe Dose of Romiplostim (AMG 531) in Patients With Myelodysplastic Syndromes (MDS)
Status: COMPLETED
Conditions: Thrombocytopenia|MDS|Myelodysplastic Syndromes|Refractory Cytopenias
Interventions: DRUG: Romiplostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Dose Finding Study of NS-065/NCNP-01 in Boys With Duchenne Muscular Dystrophy (DMD)
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: NS-065/NCNP-01|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colon Capsule Endoscopy in Children
Status: COMPLETED
Conditions: Inflammatory Bowel Disease
Interventions: DEVICE: Colon videocapsule endoscopy (PillCam colon 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Probiotic Capsules With Topical Clobetasol Propionate in OLP Treatment
Status: RECRUITING
Conditions: Oral Lichen Planus
Interventions: DRUG: Probiotic Blend Oral capsules|DRUG: Corticosteroids for Local Oral Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid With Microneedling in Melasma
Status: NOT_YET_RECRUITING
Conditions: Melasma
Interventions: DRUG: Hyaluronic acid combined with tranexamic acid microneedling|DRUG: tranexamic acid microneedling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety Study to Evaluate Bilateral CNTF Implants in Subjects With MacTel Type 2
Status: COMPLETED
Conditions: Macular Telangiectasia Type 2
Interventions: COMBINATION_PRODUCT: NT-501 CNTF implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Culturally Adapted Dietary Clinical Trial in PR
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Obesity|Hypertension|Dyslipidemias|High Triglycerides|High Blood Glucose|Abdominal Obesity
Interventions: BEHAVIORAL: Culturally tailored food and diet advice|BEHAVIORAL: Standard healthy eating advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Digital Game Use in Teaching Subcutaneous Injection Administration Skills to Nursing Students
Status: COMPLETED
Conditions: Nursing Education
Interventions: OTHER: subcutaneous injection administration game|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Long Term Effect of Adjustable Spaatz 3 Intragastric Balloon on Weight Loss
Status: TERMINATED
Conditions: Obesity|Diabetes|Hypertension
Interventions: DEVICE: Spatz 3 intragastric balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-dose Study to Evaluate the Absolute Bioavailability and Mass Balance of ONO-5788
Status: COMPLETED
Conditions: Acromegaly
Interventions: DRUG: ONO-5788|DRUG: [14C]-ONO-5788
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ricolinostat in Patients With Painful Diabetic Peripheral Neuropathy
Status: COMPLETED
Conditions: Painful Diabetic Peripheral Neuropathy
Interventions: DRUG: ricolinostat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled Doxorubicin Plus IV Docetaxel and Cisplatin in Patients With Non-Small-Cell Lung Carcinoma (NSCLC)
Status: UNKNOWN
Conditions: NSCLC
Interventions: DRUG: Doxorubicin HCl Inhalation Solution|DRUG: Docetaxel|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Northera Improves Postural Tachycardia Syndrome (POTS) and Postural Vasovagal Syncope (VVS)
Status: UNKNOWN
Conditions: Postural Tachycardia Syndrome (POTS)|Vasovagal Syncope (VVS)|Fainting
Interventions: DRUG: Northera (Droxidopa)|DRUG: Placebo|DRUG: Northera (Droxidopa)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hippocampal Sparing Whole Brain Radiation Versus Stereotactic Radiation in Patients With 5-20 Brain Metastases: A Phase III, Randomized Trial
Status: RECRUITING
Conditions: Brain Metastases
Interventions: RADIATION: Whole brain radiation|RADIATION: Stereotactic radiation (SRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of an Osteopathic Treatment Protocol on the Improvement of Sleep Quality in Young Adults With Insomnia
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: OTHER: Placebo technique|OTHER: Suboccipital inhibition technique|OTHER: Frontal lift technique|OTHER: Parietal lift technique|OTHER: IV ventricle technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Placental Transfusion Effect on Hemodynamics of Premature Newborns
Status: COMPLETED
Conditions: Pre-Term
Interventions: BIOLOGICAL: Intact umbilical cord milking (I-UCM)|BIOLOGICAL: Cut-umbilical cord milking(C-UCM)|BIOLOGICAL: Delayed Cord Clamping (DCC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Afatinib in Advanced Refractory Urothelial Cancer
Status: TERMINATED
Conditions: Distal Urethral Cancer|Proximal Urethral Cancer|Recurrent Bladder Cancer|Recurrent Urethral Cancer|Stage III Bladder Cancer|Stage III Urethral Cancer|Stage IV Bladder Cancer|Stage IV Urethral Cancer|Ureter Cancer
Interventions: DRUG: afatinib dimaleate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety and Effectiveness of ABT-510 in Subjects With Refractory Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin|Hodgkin's Lymphoma
Interventions: DRUG: ABT-510 - Thrombospondin-1 Mimetic
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Tolerability of Once Daily Inhaled Doses of GSK573719 Made With Magnesium Stearate in Subjects With Chronic Obstructive Pulmonary Disease(COPD)for 7 Days
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK573719
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Heart Health Benefits of Whole Grain Barley and Oats in Healthy Men and Women
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: OTHER: Controlled diet with whole grain barley, whole grain oats, or low grain diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Targeted Memory Reactivation for Enhancing Exposure Therapy
Status: COMPLETED
Conditions: Claustrophobia|Obsessive-Compulsive Disorder|Arachnophobia
Interventions: OTHER: Experimental Scent|OTHER: Control Scent|OTHER: No-Scent Control|BEHAVIORAL: In-Vivo Exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Solifenacin Flexible Dosing Study in Frequent Micturition Patients With and Without Urgency
Status: COMPLETED
Conditions: Urinary Bladder, Overactive|Overactive Bladder
Interventions: DRUG: Solifenacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telemedicine - Evaluation of the Impact of a Telemedicine Device (DTM) on the Prevention of Emergency Department Visits and Hospitalizations of Nursing Home Residents Aged Polypathological
Status: COMPLETED
Conditions: Polypathology
Interventions: OTHER: Telemedecine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Atezolizumab Plus Cobimetinib and Vemurafenib Versus Placebo Plus Cobimetinib and Vemurafenib in Previously Untreated BRAFv600 Mutation-Positive Patients With Metastatic or Unresectable Locally Advanced Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: DRUG: Atezolizumab|DRUG: Atezolizumab Placebo|DRUG: Cobimetinib|DRUG: Vemurafenib|DRUG: Vemurafenib Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bortezomib Followed by Pembrolizumab and Cisplatin in metTNBC
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Bortezomib; pembrolizumab and cisplatin injections--bortezomib followed by pembro/cis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: MRI in High-Grade Glioma Patients Undergoing Chemoradiation
Status: RECRUITING
Conditions: High Grade Glioma
Interventions: PROCEDURE: PET-MRI Brain Scan|DIAGNOSTIC_TEST: Blood draw|BEHAVIORAL: Memory testing|PROCEDURE: Optional lumbar puncture for cerebrospinal fluid collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Consistency of Immunogenicity and Non Inferiority of GSK Biologicals' Candidate Malaria Vaccine Lots in Children
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: GSK Biologicals' candidate Plasmodium falciparum malaria vaccine (257049)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Validation of EPIC's Readmission Risk Model, the LACE+ Index and SQLape as Predictors of Unplanned Hospital Readmissions
Status: COMPLETED
Conditions: Hospital Readmission
Interventions: OTHER: An US Readmission Risk Prediction Model|OTHER: LACE+ score|OTHER: SQLAPE model
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Avelumab in Non-Small Cell Lung Cancer (JAVELIN Lung 200)
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Avelumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HMO Research Network CERT: Acute Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction (AMI)
Interventions: BEHAVIORAL: Beta-blocker adherence after an AMI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Interactive Communication Technologies and Nicotine Replacement Therapy Sampling for Smokers
Status: COMPLETED
Conditions: Smoking Cessation|Tobacco Use Cessation
Interventions: BEHAVIORAL: Brief advice (AWARD model)|DRUG: NRT-S|BEHAVIORAL: IM Apps and Chatbot|BEHAVIORAL: Regular SMS message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study of a Multidisciplinary Treatment for Patients With Chronic Low Back Pain: PAINDOC Study.
Status: RECRUITING
Conditions: Chronic Low-back Pain
Interventions: DRUG: Usual Care|OTHER: PAINDOC Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anticholinergic Premedication Induced Fever in Pediatric Ambulatory Anesthesia With Ketamine
Status: COMPLETED
Conditions: Fever
Interventions: DRUG: Glycopyrrolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Best Partograph Action Line to Prevent Prolonged Labour
Status: COMPLETED
Conditions: Prolonged First Stage Labor - Prevention
Interventions: DEVICE: 2-hour action line on WHO modified partograph|DRUG: Oxytocin|PROCEDURE: Forewater amniotomy|DEVICE: 4-hour action line on WHO modified partograph
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Selinexor in Combination With Backbone Treatments or Novel Therapies In Participants With Relapsed or Refractory (RR) Diffuse Large B-Cell Lymphoma (DLBCL)
Status: SUSPENDED
Conditions: Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Selinexor|DRUG: Rituximab|DRUG: Bendamustine|DRUG: Polatuzumab Vedotin|DRUG: Ibrutinib|DRUG: Lenalidomide|DRUG: Tafasitamab|DRUG: Venetoclax|DRUG: Gemcitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Balloon vs. Self Expanding Transcatheter Valve for Degenerated Bioprosthesis
Status: RECRUITING
Conditions: Valve Heart Disease
Interventions: DEVICE: Evolut R/PRO bioprosthesis|DEVICE: Edwards Sapien S3/Ultra bioprosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Pharmacology of CHF 1535 50/6 ug Next DPI in Children 5-11 Years Old
Status: COMPLETED
Conditions: Asthma in Children
Interventions: DRUG: free comb. beclomethasone DPI and formoterol DPI|DRUG: CHF 1535 50/6 NEXT DPI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Peri-operative Glucocorticoids on Short-term Functional Outcome After THA
Status: RECRUITING
Conditions: Coxarthrosis|Avascular Necrosis of Hip
Interventions: DRUG: High dose of peri-operative intravenous dexamethasone|DRUG: Low dose of peri-operative intravenous dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tough Talks: A Disclosure Intervention for HIV+ Young Men Who Have Sex With Men (YMSM)
Status: COMPLETED
Conditions: Hiv|HIV/AIDS|Disclosure
Interventions: BEHAVIORAL: Tough Talks Online|BEHAVIORAL: Tough Talks Clinic|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of AK104 Monotherapy or AK104 Plus Axitinib in Advanced/Metastatic Renal Cell Carcinoma
Status: RECRUITING
Conditions: Renal Cell Carcinoma|First-line Treatment
Interventions: DRUG: AK104|DRUG: axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visionaire™ Versus Standard Instrumentation Safety and Efficacy in Total Knee Arthroplasty (TKA)
Status: TERMINATED
Conditions: Degenerative Arthritis of Knee
Interventions: OTHER: VISIONAIRE Total Knee Arthroplasty|OTHER: Standard Total Knee Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Performance of PET 18 F-FDG Coupled to CT With Contrast Injection Iodized in the Diagnosis of Early Recurrences of Head and Neck Carcinoma Treated With Concurrent Chemoradiation. Comparison With 18F-FDG PET Coupled With CT Not Injected With Filling CT Standard Injection
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: OTHER: 18F-FDG PET combined with CT with iodinated contrast injection|OTHER: 18F-FDG PET combined with CT without injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Outcomes After Medical and Surgical Treatment of Gastroesophageal Reflux Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastroesophageal Reflux Disease
Interventions: BEHAVIORAL: Questionnaires to evaluate QOL|BEHAVIORAL: Questionnaires to evaluate heartburn and quality of life|BEHAVIORAL: Questionnaire to evaluate satisfaction with treatment|BEHAVIORAL: Questionnaire to evaluate presence or absence of pain
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Incidence, Characteristics and Evolution of Cerebral Vasospasm With Clinical Impact in Moderate to Severe Traumatic Brain Injury Complicated by Subarachnoid Hemorrhage at Martinique University Hospital
Status: NOT_YET_RECRUITING
Conditions: SAH (Subarachnoid Hemorrhage)|Cerebral Vasospasm|Moderate Traumatic Brain Injury|Severe Traumatic Brain Injury
Interventions: PROCEDURE: Additional realization of a brain perfusion scan sequence which would allow the radiological diagnosis of CV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Effects of Dietary Fiber on Blood Lipids in Men and Women
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: OTHER: dietary fiber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Optimal Type of Inhaler in Cough Variant- or Cough Predominant Asthma
Status: COMPLETED
Conditions: Asthma|Cough Variant Asthma
Interventions: DEVICE: Budesonid or budesonide/fomoterol administered by DPI|DEVICE: Budesonid or budesonide/fomoterol administered by MDI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of 3 Doses of BI1356 (Linagliptin) in Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo|DRUG: BI 1356 dose 3 once daily|DRUG: BI 1356 dose 2 once daily|DRUG: BI 1356 dose 1 once daily|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Total-Body Irradiation, Tacrolimus, and Mycophenolate Mofetil Plus Bone Marrow Transplantation in Treating Patients With Hematologic Cancers
Status: COMPLETED
Conditions: Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: peripheral blood lymphocyte therapy|DRUG: mycophenolate mofetil|DRUG: tacrolimus|PROCEDURE: allogeneic bone marrow transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: INTEGRA: A Vanguard Study of Health Service Delivery in a Mobile Health Delivery Unit
Status: ENROLLING_BY_INVITATION
Conditions: HIV Infections|Drug Use|Opioid Use|Opioid-use Disorder
Interventions: DRUG: Medication for opioid-use disorder (MOUD) for opioid-use disorder (OUD)|DIAGNOSTIC_TEST: HIV testing|DRUG: HIV treatment for participants living with HIV not already in care|DRUG: PrEP for participants without HIV|DIAGNOSTIC_TEST: Testing and referral for vaccination or treatment for hepatitis A virus (HAV) and hepatitis B virus (HBV)|DIAGNOSTIC_TEST: Testing and referral for treatment for hepatitis C virus (HCV)|DIAGNOSTIC_TEST: Sexually transmitted infection (STI) testing and treatment|OTHER: Primary care|BEHAVIORAL: Harm reduction services|BEHAVIORAL: Peer navigation|DIAGNOSTIC_TEST: COVID-19 testing and referral for further evaluation, care and/or treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: TOPARP: A Phase II Trial of Olaparib in Patients With Advanced Castration Resistant Prostate Cancer
Status: UNKNOWN
Conditions: Adenocarcinoma of the Prostate
Interventions: DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Desiccated Thyroid Extract and Levothyroxine for Hypothyroidism Treatment
Status: UNKNOWN
Conditions: Primary Hypothyroidism.
Interventions: DRUG: Levothyroxine|DRUG: Desiccated thyroid extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Pediatric Germ Cell Tumor|Extragonadal Germ Cell Tumor
Interventions: DRUG: cisplatin|DRUG: etoposide|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Ofatumumab and Bendamustine Hydrochloride With or Without Bortezomib in Treating Patients With Untreated Follicular Non-Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Ann Arbor Stage III Grade 1 Follicular Lymphoma|Ann Arbor Stage III Grade 2 Follicular Lymphoma|Ann Arbor Stage III Grade 3 Follicular Lymphoma|Ann Arbor Stage IV Grade 1 Follicular Lymphoma|Ann Arbor Stage IV Grade 2 Follicular Lymphoma|Ann Arbor Stage IV Grade 3 Follicular Lymphoma|Grade 3a Follicular Lymphoma
Interventions: DRUG: Bendamustine Hydrochloride|DRUG: Bortezomib|RADIATION: Fludeoxyglucose F-18|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Ofatumumab|PROCEDURE: Positron Emission Tomography with Radiolabeled Targeting Agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nimotuzumab Plus Radiotherapy With Concomitant and Adjuvant Temozolomide for Cerebral Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma
Interventions: BIOLOGICAL: Nimotuzumab|DRUG: Temozolomide|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Pneumatic Compression of the Upper Extremity for Post-Operative VTE Prophylaxis
Status: COMPLETED
Conditions: Venous Thromboses
Interventions: DEVICE: Intermittent Pneumatic Compression Device (FDA approved)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Macrolides to Prevent Exacerbations of Asthma and Chronic Obstructive Pulmonary Disease
Status: TERMINATED
Conditions: Asthma|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: PERFECT Project - Part 1 - Study 2
Status: COMPLETED
Conditions: Diabetes Prevention|Obesity Prevention
Interventions: OTHER: Control|OTHER: Pea protein|OTHER: Pea starch|OTHER: Pea fibre + pea starch|OTHER: Pea protein + pea starch|OTHER: Pea fibre + pea starch + pea protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Role of Expectations in the Pharmacological Treatment of Depression - An Experimental Investigation
Status: COMPLETED
Conditions: Major Depressive Episode
Interventions: OTHER: Placebo nasal spray|OTHER: Film sequence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Transcutaneous Electric Nerve Stimulation for Pain Relief During Extracorporeal Shock-wave Lithotripsy
Status: UNKNOWN
Conditions: Pain
Interventions: DEVICE: Transcutaneous electrical nerve stimulation|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Boost for Locally Advanced Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer|Lung Cancer|NSCLC
Interventions: RADIATION: Stereotactic boost|RADIATION: Conventional RT|DRUG: Etoposide|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Finhyst 2006: Study on Morbidity of Hysterectomies in Finland
Status: COMPLETED
Conditions: Morbidity of Hysterectomy
Interventions: PROCEDURE: laparoscopy|PROCEDURE: vaginal|PROCEDURE: abdominal
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TOtal tRansfemoral branCHed endovasCular tHoracoabdominal Aortic Repair Registry
Status: COMPLETED
Conditions: Aortic Aneurysm, Abdominal|Aortic Aneurysm, Thoracic
Interventions: DEVICE: Steerable introducers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Development of an Optimal Antibiotic Regime for Long-term Therapy in Stable Chronic Obstructive Pulmonary Disease (COPD)
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease (COPD).
Interventions: DRUG: Moxifloxacin|DRUG: Azithromycin|DRUG: Doxycycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Drug-drug Interaction Study of CHF5993 With Cimetidine
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: CHF 5993 pMDI|DRUG: Cimetidine plus CHF5993 pMDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Effects of Green Coffee Bean Extract (GCE) on Physiological and Psychological Variables
Status: WITHDRAWN
Conditions: Blood Pressure
Interventions: DIETARY_SUPPLEMENT: decaffeinated coffee|DIETARY_SUPPLEMENT: chlorogenic acid|DIETARY_SUPPLEMENT: green coffee bean extract supplement|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sugammadex To IMprove Bowel Function
Status: COMPLETED
Conditions: Bowel Dysfunction|Postoperative Complications|Neuromuscular Blockade
Interventions: DRUG: Sugammadex|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION