pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of HITHOC After Pleurectomy Decortication for Treatment of Malignant Pleural Mesothelioma
Status: RECRUITING
Conditions: Malignant Pleural Mesothelioma|Chemotherapy Effect
Interventions: PROCEDURE: hyperthermic intrathoracic chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DKutting Balloon Versus Chocolate Balloon to Treat Femoral and Popliteal Artery Stenosis
Status: COMPLETED
Conditions: Femoral Artery Stenosis|Popliteal Artery Stenosis
Interventions: DEVICE: DKutting LL balloon|DEVICE: Chocolate balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Two Novel Hydration Beverage Formulas on Rehydration in Adults
Status: RECRUITING
Conditions: Dehydration
Interventions: DIETARY_SUPPLEMENT: Control: Water|DIETARY_SUPPLEMENT: Liquid IV hydration multiplier|DIETARY_SUPPLEMENT: Liquid IV sugar-free hydration multiplier
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dose-Escalating Multiple Dose Study of PD-0360324 in Combination With Methotrexate in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: PD 0360324|DRUG: PD 0360324|DRUG: PD 0360324|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2, Open-Label, Single Arm Study, With BST-236 in Adults With R/R AML or Higher-Risk MDS
Status: UNKNOWN
Conditions: AML, Adult|MDS|Relapse/Recurrence|Refractory Acute Myeloid Leukemia
Interventions: DRUG: BST-236
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Retrospective Cohort Study: The Influence of MTHFR C677T and A1298C on the High-dose Methotrexate-Related Toxicities in Pediatric Patients With Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Pediatric NHL
Interventions: DRUG: High-dose MTX based chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 12-Week Study Assessing Change in Psoriasis Severity and Level of Stress Using TEN
Status: COMPLETED
Conditions: Psoriasis|Stress
Interventions: DEVICE: Transdermal Electrical Neuromodulator (TEN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Managing Dysfunctional Breathing and Exercise-induced Laryngeal Obstruction in Adolescent Athletes
Status: COMPLETED
Conditions: Exercise Induced Laryngeal Obstruction (EILO)
Interventions: OTHER: Norwegian psychomotor physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II RCT of an Internet-adaptation of Managing Cancer and Living Meaningfully (iCALM)
Status: RECRUITING
Conditions: Advanced Cancer
Interventions: BEHAVIORAL: Internet Adaptation of Managing Cancer and Living Meaningfully (iCALM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of an Oral Rehydration Solution Containing the Probiotic Lactobacillus Reuteri Protectis and Zinc in Infants With Acute Gastroenteritis
Status: COMPLETED
Conditions: Acute Gastroenteritis
Interventions: DIETARY_SUPPLEMENT: ORS rehydration solution|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: STN DBS - Theta Burst|DEVICE: STN DBS - Gamma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanistic Study of the Systolic Blood Pressure Lowering Effect of Dapagliflozin in Type 2 Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: dapagliflozin|DRUG: glimpiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Teriflunomide in Patients With Relapsing Multiple Sclerosis and Treated With Interferon-beta
Status: TERMINATED
Conditions: Multiple Sclerosis Relapse
Interventions: DRUG: Teriflunomide|DRUG: Placebo (for teriflunomide)|DRUG: Interferon-beta (IFN-beta)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Subintimal vs Intraluminal Approach for Atherosclerotic Chronic Occlusive Femoropopliteal Arterial Disease
Status: UNKNOWN
Conditions: Peripheral Arterial Disease|Atherosclerosis
Interventions: PROCEDURE: Intentional intraluminal approach|PROCEDURE: Intentional subintimal approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lumigan Versus Cosopt
Status: COMPLETED
Conditions: Open-Angle Glaucoma
Interventions: DRUG: bimatoprost 0.03%|DRUG: dorzolamide 2%/timolol maleate 0.5% fixed combination|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Conventional and Diode Laser-Assisted Frenectomy in Patients With Abnormal Different Frenum Insertions: A Retrospective Study
Status: COMPLETED
Conditions: Frenulum; Elongation
Interventions: DEVICE: Diode laser|PROCEDURE: Conventional
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: AcoArt sICAS: DCB in the Treatment of Symptomatic Intracranial Atherosclerotic Stenosis
Status: COMPLETED
Conditions: Intracranial Atherosclerosis|Stroke
Interventions: DEVICE: drug coated balloon|DEVICE: stent system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Fusion The IVANOS-study
Status: COMPLETED
Conditions: Spinal Stenosis|Low Back Pain
Interventions: PROCEDURE: i-FACTOR|PROCEDURE: Allograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-Blind Group Comparative Study To Evaluate the Long-Term Safety and Effectiveness of Two Different Doses of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients With Multiple Episodes of PCP
Status: COMPLETED
Conditions: Pneumonia, Pneumocystis Carinii|HIV Infections
Interventions: DRUG: Pentamidine isethionate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Self-management Program for Temporomandibular Myalgia in Subjects With Fibromyalgia: a Single Arm Study
Status: RECRUITING
Conditions: Temporomandibular Disorder|Fibromyalgia
Interventions: OTHER: Self management
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ezetimibe in Patients Hypo-responsive to Statins
Status: TERMINATED
Conditions: High Cholesterol|Coronary Artery Disease
Interventions: DRUG: Ezetimibe|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The STEP 4Life Trial
Status: COMPLETED
Conditions: Alzheimer Disease, At Risk|Alzheimer Disease, Protection Against|Dementia
Interventions: BEHAVIORAL: Gamification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Observational Study of the Quality of Life for the Chronic Pain Patients Included in a Therapeutic Education Program Focused on Relaxation Techniques
Status: UNKNOWN
Conditions: Chronic Pain
Interventions: OTHER: questionnary SF36|OTHER: Hospital Anxiety and Depression Scale|OTHER: Chronic Pain Acceptance Questionnaire|OTHER: digital pain scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Liposomal vs. Conventional Bupivacaine for Pain Control
Status: RECRUITING
Conditions: Local Anesthetics|Analgesia|Regional Block|Paravertebral Block
Interventions: DRUG: Performing paravertebral nerve block with lipo-bupivacaine|DRUG: Performing paravertebral nerve block with bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stromal Cells for COVID-19 and Viral Pneumonias
Status: NOT_YET_RECRUITING
Conditions: COVID-19 Pneumonia|Viral Pneumonia
Interventions: BIOLOGICAL: Allogeneic Mesenchymal Stromal Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GlideScope® vs GlideScope® + aScope® for Managing Difficult Airways.
Status: UNKNOWN
Conditions: Airway Morbidity|Anesthesia Intubation Complication
Interventions: DEVICE: aScope®|DEVICE: Glidescope®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Aluminaid Versus Hydrogel Wound Dressings
Status: TERMINATED
Conditions: Partial-thickness Burn
Interventions: DEVICE: Aluminaid|DEVICE: Hydrogel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Bioavailability of Naproxen 375 mg in Two Formulations
Status: COMPLETED
Conditions: Arthritis
Interventions: DRUG: PN400|DRUG: Naproxen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multiple Ascending Dose Study of GLPG0634 in Japanese and Caucasian Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG0634 50 mg|DRUG: GLPG0634 100 mg|DRUG: GLPG0634 200 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Radiotherapy in Early Stage Oral Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer of Mouth|Cancer of the Tongue|Cancer of the Head and Neck|Buccal Mucosa Cancer|Floor of Mouth Carcinoma
Interventions: RADIATION: Post-operative adjuvant radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab Plus Nab-paclitaxel and Platinum for Immunotherapy-treated Non-squamous Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer Metastatic
Interventions: COMBINATION_PRODUCT: bevacizumab plus nab-paclitaxel and platinum
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Efficacy of Symbicort® Turbuhaler® (1, 2, and 4 x 160/4.5 µg Twice Daily) in Japanese Patients With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Budesonide/Formoterol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rotator Cuff Repair (RCR) With and Without OrthoADAPT Augmentation
Status: WITHDRAWN
Conditions: Rotator Cuff Tear
Interventions: DEVICE: OrthoADAPT|PROCEDURE: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Fostamatinib in Subjects With Impaired Hepatic (Liver) Function
Status: COMPLETED
Conditions: Hepatic Impairment|Healthy Volunteers|Pharmacokinetics|Amount of R406 in Blood
Interventions: DRUG: Fostamatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase I, Exploratory, Single Centre, Single Oral Dose AZD9668 and Intravenous Microdose of [C14] AZD9668, Healthy Subject
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD9668
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bioequivalence Of A Test Alprazolam Sublingual Formulation Compared To A Commercial Sublingual Formulation
Status: WITHDRAWN
Conditions: Healthy
Interventions: DRUG: alprazolam sublingual tablet commercial|DRUG: alprazolam sublingual tablet test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Recurrence Gene Profiles of Adjuvant Osimertinib Therapy in Resected Non-Small-Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ZILRETTA™ for Treatment of Idiopathic Adhesive Capsulitis
Status: UNKNOWN
Conditions: Adhesive Capsulitis|Frozen Shoulder|Adhesive Capsulitis of Shoulder
Interventions: DRUG: triamcinolone acetonide extended-release injectable suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Consequences of Antiangiogenic Factors Involved in Preeclampsia on Intra-uterine Growth Restricted Preterm Newborn
Status: COMPLETED
Conditions: Preterm Birth|Intra-uterine Growth Restriction|Maternal Preeclampsia|Bronchopulmonary Dysplasia
Interventions: OTHER: Biological samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of COX2 on Sera Biomarkers From Obese Subjects
Status: COMPLETED
Conditions: Breast Cancer Survivors
Interventions: DRUG: Aspirin|DIETARY_SUPPLEMENT: Omega 3 FFA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparision of the Clinical Efficacy of Different Desensitizing Toothpastes
Status: COMPLETED
Conditions: Dentine Hypersensitivity
Interventions: OTHER: Sodium Monofluorophosphate|OTHER: Stannous Fluoride|OTHER: Nano-Hydroxyapatite|OTHER: 8% Arginine & Calcium Carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Elastic Nail Versus Screw for Intramedullary Fixation of Displaced Fractures of the Fifth Metacarpal Neck
Status: RECRUITING
Conditions: Metacarpal Fracture|Boxer's Fracture
Interventions: DIAGNOSTIC_TEST: Radiologic examination|PROCEDURE: Grip Strength|OTHER: Quick DASH Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Compare Treatment With GP2017 and Humira® in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Adalimumab - GP2017|BIOLOGICAL: Adalimumab - US licensed Humira
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nutri-jelly on Quality of Life in Head and Neck Cancer Patients
Status: COMPLETED
Conditions: Head and Neck Cancer|Dysphagia
Interventions: DIETARY_SUPPLEMENT: Nutri-jelly
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Comparison of ISIS 2922 Used Immediately or Later in Patients With Cytomegalovirus (CMV) of the Eyes
Status: COMPLETED
Conditions: Cytomegalovirus Retinitis|HIV Infections
Interventions: DRUG: Fomivirsen sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Improving the Quality of Patient Care by Using a Clinical Expert System.
Status: COMPLETED
Conditions: Hypertension|Diabetes|Hypercholesterolemia|Vasculitis|Coronary Heart Diseases
Interventions: DEVICE: Computer-assisted history|PROCEDURE: physician taken history|OTHER: Computer-assisted history taking
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Oral Upadacitinib Tablet Compared to Placebo in Adult Participants With Moderate to Severe Hidradenitis Suppurativa to Assess Change in Disease Symptoms
Status: COMPLETED
Conditions: Hidradenitis Suppurativa (HS)
Interventions: DRUG: Upadacitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aripiprazole Treatment for Methamphetamine Dependence Among High-risk Individuals
Status: COMPLETED
Conditions: Substance Abuse|HIV Infections
Interventions: DRUG: Aripiprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Individual vs Cohort Long Distance Advising for Mental Care for Congenital Cataract Guardians
Status: COMPLETED
Conditions: Cataract
Interventions: OTHER: phone call|OTHER: wechat group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Pilot Study of Eribulin in Breast Cancer (BC) Patients With Brain Metastases Previously Treated With Anthracyclines and Taxanes
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Eribulin Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare Subjective Drug Liking & Pharmacokinetics of Vyvanse™ and ADDERALL XR® When Administered as an Oral Solution
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: Lisdexamfetamine Dimesylate|DRUG: Racemic mixture of dextroamphetamine and lisdexamfetamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Comparing the "snifﬁng Position" , "Simple Head Extension" and "Neutral Position"
Status: COMPLETED
Conditions: Therapeutic Procedural Complication
Interventions: DEVICE: snifﬁng Position(place a 7-cm cushion under head )|DEVICE: Simple Head Extension(without cushion)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: COMPRES - COMpression Anastomosis Ring (CAR™ 27/ColonRing™) Post maRketing Evaluation Study
Status: COMPLETED
Conditions: Colorectal Surgery
Interventions: DEVICE: ColonRing (Colorectal anastomosis)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Stereotactic Body Radiation Therapy (SBRT) Hepatocellular Carcinoma (COLD 2)
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: RADIATION: Stereotactic Body Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Surgical Mesh for Inguinal Hernia Repair
Status: UNKNOWN
Conditions: Hernia, Inguinal
Interventions: DEVICE: Biomerix Revive™ (surgical mesh for inguinal hernia repair)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Ustekinumab Maintenance Therapy in Patients With Moderately to Severely Active Crohn's Disease (IM-UNITI)
Status: COMPLETED
Conditions: Crohn's Disease|Colitis|IBD|Inflammatory Bowel Disease
Interventions: DRUG: Placebo SC|DRUG: Placebo IV|DRUG: Ustekinumab 90 mg SC q8w|DRUG: Ustekinumab 130 mg IV|DRUG: Ustekinumab 90 mg SC q12w
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ceftolozane-tazobactam for the Treatment of Respiratory Infections Due to Extensively Drug-resistant Pseudomonas Aeruginosa Among Critically Ill Patients: a Retrospective Study.
Status: UNKNOWN
Conditions: Ventilator Associated Pneumonia|Antibiotic Resistant Infection
Interventions: DRUG: Ceftolozane/tazobactam
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combining Radiation Therapy With Immunotherapy for the Treatment of Metastatic Squamous Cell Carcinoma of the Head and Neck
Status: RECRUITING
Conditions: Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Metastatic Head and Neck Squamous Cell Carcinoma|Metastatic Hypopharyngeal Squamous Cell Carcinoma|Metastatic Laryngeal Squamous Cell Carcinoma|Metastatic Oral Cavity Squamous Cell Carcinoma|Metastatic Oropharyngeal Squamous Cell Carcinoma|Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8|Stage IV Hypopharyngeal Carcinoma AJCC v8|Stage IV Laryngeal Cancer AJCC v8|Stage IV Lip and Oral Cavity Cancer AJCC v8|Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Interventions: DRUG: Carboplatin|DRUG: Cisplatin|PROCEDURE: Computed Tomography|DRUG: Fluorouracil|PROCEDURE: Magnetic Resonance Imaging|DRUG: Paclitaxel|BIOLOGICAL: Pembrolizumab|PROCEDURE: Positron Emission Tomography|OTHER: Quality-of-Life Assessment|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MExiletine Versus Lamotrigine in Non-Dystrophic Myotonias
Status: RECRUITING
Conditions: Non-Dystrophic Myotonia
Interventions: DRUG: Mexiletine|DRUG: Lamotrigine 25Mg Oral Tablet, Extended Release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Women With Advanced Breast Cancer
Status: WITHDRAWN
Conditions: Stage IV Breast Cancer|Recurrent Breast Cancer
Interventions: DRUG: antineoplaston A10|DRUG: antineoplaston AS2-1|PROCEDURE: alternative product therapy|PROCEDURE: biological therapy|PROCEDURE: biologically based therapies|PROCEDURE: cancer prevention intervention|PROCEDURE: complementary and alternative therapy|PROCEDURE: differentiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study Investigating the Efficacy and Safety of ABT-494 Given With Methotrexate in Subjects With Rheumatoid Arthritis Who Failed Anti-Tumor Necrosis Factor (TNF) Biologic Therapy
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: ABT-494|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Phenoxybenzamine Use in Pediatric Patients Undergoing Open-Heart Surgery
Status: COMPLETED
Conditions: Open-heart Surgery|Cardiopulmonary Bypass
Interventions: DRUG: Phenoxybenzamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin A as a Treatment for Provoked Vestibulodynia
Status: COMPLETED
Conditions: Vulvodynia
Interventions: DRUG: botulinum toxin A|DRUG: NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CYTO Reductive Surgery in Kidney Cancer Plus Immunotherapy and Targeted Kinase Inhibition
Status: RECRUITING
Conditions: Kidney Cancer|Renal Cell Carcinoma
Interventions: DRUG: Cabozantinib|DRUG: Nivolumab|PROCEDURE: Cytoreductive nephrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Coronary Microvascular Dysfunction Post-PCI by Intracoronary Nicardipine
Status: WITHDRAWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Nicardipine|DRUG: Sterile Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Risk-based Sequential Screening for Esophageal and Gastric Cancer
Status: RECRUITING
Conditions: Esophageal Cancer|Gastric Cancer|Precision Screening|Sequential Screening|Risk Stratification
Interventions: PROCEDURE: Risk Assessment and Individualized Surveillance|PROCEDURE: Universal screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: An Evaluation of the Efficacy and Safety of TOLAMBA™ for Ragweed-Allergic Rhinitis in an Environmental Exposure Chamber
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal
Interventions: BIOLOGICAL: Amb a 1 Immunostimulatory Oligoribonucleotide Conjugate|DRUG: Histamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endocrinological and Physiological Responses to Short-term Reduced Carbohydrate Availability in Males
Status: COMPLETED
Conditions: Energy Supply; Deficiency|Carbohydrate Availability
Interventions: OTHER: Nutritional/dietary intake manipulation ('Normal')|OTHER: Nutritional/dietary intake manipulation ('Low')
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Local Collagen-Gentamicin and Extra Fixation of the Sternum for Prevention of Sternal Wound Infection in Cardiac Surgery
Status: COMPLETED
Conditions: Drug Resistance, Bacterial|Postoperative Wound Infection
Interventions: DRUG: Local application of collagen-gentamicin|PROCEDURE: Fixation of the sternotomy with more than six wires
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Open-Label Dose-Escalation Study to Evaluate XmAb24306 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Solid Tumors
Interventions: DRUG: XmAb24306|DRUG: Atezolizumab|DRUG: XmAb24306
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maximal Suppression of the Androgen Axis in Clinically Localized Prostate Cancer
Status: COMPLETED
Conditions: Cancer|Prostate Neoplasms
Interventions: DRUG: goserelin with dutasteride|DRUG: goserelin with bicalutamide and dutasteride|DRUG: goserelin with bicalutamide and dutasteride and ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Menstrual Migraine Treatment With TREXIMET (Formerly Known as TREXIMA)
Status: COMPLETED
Conditions: Migraine|Migraine Disorders
Interventions: DRUG: sumatriptan succinate/naproxen sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Eosinophil-guided Reduction of Inhaled Corticosteroids
Status: RECRUITING
Conditions: COPD|Inhaled Corticosteroid|Azithromycin|COPD Exacerbation|Pneumonia
Interventions: DRUG: Azithromycin|DRUG: ICS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Accuracy of Full Digital Workflow for Guided Implant Surgery Using the R2 Gate Software
Status: COMPLETED
Conditions: Partially Edentulous Maxilla|Partially Edentulous Mandible
Interventions: PROCEDURE: Full digital workflow|PROCEDURE: Partially digital workflow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Effect of Formoterol vs Salmeterol on Small Airways Physiological Parameters in COPD Patients
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Atimos®|DRUG: Serevent™|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Portuguese Observational Survey to Assess Drug Adherence in Patients With Multiple Sclerosis After Conversion to Betaferon by Using Elements of the BetaPlus Program - Nurse Support, Auto-injectors
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis (RRMS)|Secondary Progressive Multiple Sclerosis (SPMS)
Interventions: DRUG: Interferon beta-1b (Betaseron, BAY86-5046)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Valdecoxib and Naproxen in Treating the Signs and Symptoms of Rheumatoid Arthritis (RA) in a Severe Rheumatoid Arthritis Patients
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: valdecoxib|DRUG: naproxen|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Modelle 001, TS-inhibition in Colorectal Liver Metastases Comparing Arfolitixorin and Calciumfolinate
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Arfolitixorin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preservation vs. Dissection of Inferior Pulmonary Ligament for Thoracoscopic Upper Lobectomy
Status: COMPLETED
Conditions: Lung Diseases
Interventions: PROCEDURE: Dissection of the Inferior Pulmonary Ligament|PROCEDURE: Preservation of the Inferior Pulmonary Ligament
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Nasal Irrigation Using Mucolytic Agents
Status: UNKNOWN
Conditions: Surgical Procedure, Unspecified
Interventions: DRUG: saline nasal irrigation alone|DRUG: dissolved N-Acetylcystine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of Two Ciprofloxacin/Dexamethasone Formulations in Patients With Otitis Externa
Status: TERMINATED
Conditions: Otitis Externa
Interventions: DRUG: Ciprofloxacin/Dexamethasone|DRUG: Ciprodex (R)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of VRG50635 in Participants With Amyotrophic Lateral Sclerosis (ALS)
Status: RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: VRG50635
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Inhaled Interferon Gamma-1b in Pulmonary MAC Infection
Status: TERMINATED
Conditions: Lung Infection
Interventions: DRUG: interferon gamma-1b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Isometric Intervention for Lateral Elbow Tendinopathy
Status: WITHDRAWN
Conditions: Lateral Elbow Tendinopathy|Elbow Pain|Elbows Tendonitis|Elbow Sprain|Elbow Injury
Interventions: PROCEDURE: isometric intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First-In-Human Study of LY3839840 in Healthy Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DRUG: LY3839840|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study in Asthmatic Children (6 to <12 Yrs) Comparing Single Doses of Formoterol and Foradil® Evaluating Efficacy
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: 80/2.25 μg Symbicort pMDI|DRUG: 80/4.5 μg Symbicort pMDI|DRUG: Foradil Aerolizer 12 μg|DRUG: 40 μg budesonide HFA pMDI|DRUG: placebo HFA pMDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Ramelteon (8mg) Alone and in Combination With Multi-Component Behavioral Therapy on Sleep and Circadian Phase in Patients With Chronic Insomnia
Status: UNKNOWN
Conditions: Insomnia
Interventions: DRUG: Placebo|DRUG: Rozerem 8mg|OTHER: Rozerem 8mg in combination with Multi Component Behavior Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MBM-02 (Tempol) for the Treatment of Biochemical Recurrent Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer Recurrent|Biochemical Recurrent Prostate Cancer
Interventions: DRUG: MBM-02
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Myeloablative Double Unit Umbilical Cord Blood Transplantation in Adult Patients
Status: UNKNOWN
Conditions: Hematologic Malignancy
Interventions: PROCEDURE: Myeloablative double unit cord blood transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness Study of Eximo's B-Laser™ Atherectomy Device for PAD Treatment
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: B-Laser™ Atherectomy Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Screening for Advanced Heart Failure IN Stable outPatientS - The SAINTS Study (SAINTS B)
Status: RECRUITING
Conditions: Advanced Heart Failure|Heart Failure With Reduced Ejection Fraction
Interventions: DEVICE: CardioMEMS HF System|DRUG: Standard heart failure medical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Two-Needle vs. Surgery-Guided Arthrocentesis for TMJ Disorders
Status: COMPLETED
Conditions: Temporomandibular Joint Disorders
Interventions: PROCEDURE: Traditional Two-Needle Arthrocentesis|PROCEDURE: Surgery-Guided Arthrocentesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Everolimus (RAD001) in Combination With Lenalidomide
Status: COMPLETED
Conditions: Solid Organ Malignancies|Adenoidcystic Carcinoma|Neuroendocrine Tumors
Interventions: DRUG: Lenalidomide|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Medicinal Mushroom Agaricus Blazei Protect Against Allergy and Asthma?
Status: COMPLETED
Conditions: Pollen; Allergy, Asthma
Interventions: DIETARY_SUPPLEMENT: Agaricus blazei Murill-based mushroom extract, Andosan™|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Brief Cognitive Behavioral Therapy Versus Crisis Intervention Therapy Through Telepsychiatry on Psychiatric Symptoms
Status: UNKNOWN
Conditions: Anxiety|Depressive Symptoms|Post Traumatic Stress Symptoms|Perceived Stress
Interventions: BEHAVIORAL: Brief cognitive behavioral therapy|BEHAVIORAL: Crisis intervention therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect and Mechanism of Jiajian Guishen Formulation on Premature Ovarian Insufficiency Based on Metabolomics
Status: RECRUITING
Conditions: Premature Ovarian Insufficiency|Metabolomics|Traditional Chinese Medicine|Mechanism|Clinical Syndrome
Interventions: DRUG: Jiajian Guishen Formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the Liver
Status: RECRUITING
Conditions: Colorectal Cancer|Liver Metastases|Colorectal Adenocarcinoma|Colorectal Cancer With Hepatic Metastases|Colorectal Carcinoma
Interventions: DEVICE: Codman 3000 constant flow pump catheter|DRUG: Panitumumab|DRUG: FUDR-Dex|DRUG: Oxaliplatin|DRUG: 5FU|DRUG: Irinotecan|PROCEDURE: HAIP installation|DRUG: cetuximab|DEVICE: Medtronic SynchroMed II Pump
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Bortezomib in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: bortezomib|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: prednisolone|DRUG: vincristine sulfate|OTHER: questionnaire administration|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Partial Dietary Replacement From Animal to Plant-Based Protein for Type 2 Diabetes Management
Status: RECRUITING
Conditions: Type 2 Diabetes|Overweight|Obesity
Interventions: BEHAVIORAL: Control Diet|BEHAVIORAL: Plant-based Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Pharmacokinetics of Vitamin D (Cholecalciferol) in Patients Undergoing Obesity Surgery in a Deficit Situation and After Standardization
Status: UNKNOWN
Conditions: Obesity|Gastric Bypass|Gastrectomy
Interventions: DRUG: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Nicotine Cigarettes in Smokers With and Without Alcohol Use Disorder
Status: COMPLETED
Conditions: Alcohol Drinking|Cigarette Smoking Toxicity
Interventions: DRUG: Reduced nicotine cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mecapegfilgrastim With Chemotherapy for Peripheral Blood Stem Cell Mobilization in MM and Lymphoma
Status: RECRUITING
Conditions: Multiple Myeloma|Lymphoma
Interventions: DRUG: Etoposide|DRUG: Cyclophosphamide|DRUG: Mecapegfilgrastim, day 2|DRUG: Mecapegfilgrastim, day 5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Static Progressive Stretch Versus Traditional Stretch in Adhesive Capsulitis
Status: COMPLETED
Conditions: Adhesive Capsulitis|Stretch|Physical Neglect
Interventions: DEVICE: Static progressive stretching|OTHER: Cyclic manual stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of GIP, GLP-1 and GLP-2 in Individuals With Genetically Altered Receptor Function
Status: RECRUITING
Conditions: Incretin Effect
Interventions: DRUG: GIP(1-42)|DRUG: GLP-1|DRUG: GLP-2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Oral D-mannose Tablets on Pharmacokinetics of Dabigatranate in Healthy Adults
Status: RECRUITING
Conditions: Health
Interventions: DRUG: Dabigatran Etexilate|DIETARY_SUPPLEMENT: D-mannose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Open-Label Multicenter Phase 2 Window of Opportunity Study Evaluating Ganetespib in Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|HER-2 Positive Breast Cancer|Triple Negative Breast Cancer|ER/Progressive Response (PR) + Refractory to Prior Hormonal Treatment
Interventions: DRUG: ganetespib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Childhood Obesity Treatment Designed for Low Income and Hispanic Families
Status: RECRUITING
Conditions: Pediatric Obesity|Healthy Eating|Physical Activity|Minority Health|Mindfulness|Family|Counseling
Interventions: BEHAVIORAL: The Healthy Living Program/La Vida Saludable|BEHAVIORAL: Recommended Treatment of Obesity in Primary Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Arteriovenous Fistula Patency
Status: COMPLETED
Conditions: Thrombosis
Interventions: DEVICE: Second generation surveillance of AVF|PROCEDURE: vital signs|PROCEDURE: physical examination of AVF|PROCEDURE: ktv test|PROCEDURE: urea method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of FG-4592 in Subjects With End-Stage Renal Disease Receiving Maintenance Hemodialysis in China
Status: COMPLETED
Conditions: Anemia in End Stage Renal Disease
Interventions: DRUG: FG-4592|DRUG: Epoetin Alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double Masked, Parallel Group, Dose-finding Study to Evaluate SYL1801 in Patients With Neovascular Age-related Macular Degeneration (AMD)
Status: RECRUITING
Conditions: Wet Macular Degeneration|Neovascular Age-related Macular Degeneration|Macular Degeneration
Interventions: DRUG: SYL1801
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Acceptance and Commitment Therapy Based Interventions on Mental Health and Cognitive Impairment for Patients With Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Acceptance and Commitment Therapy, Mental Health, Cognitive Impairment,Colorectal Cancer
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy, Safety and Costs of Methotrexate, Adalimumab, or Their Combination in Non-infectious Non-anterior Uveitis
Status: RECRUITING
Conditions: Uveitis
Interventions: DRUG: Methotrexate|DRUG: Adalimumab|DRUG: Adalimumab+Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Levosimendan for Cardiac Patients Undergoing Major Abdominal Cancer Surgeries
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Levosimendan|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fruquintinib Plus PD-1 Antibody in pMMR / MSS Locally Advanced Rectal Cancer (LARC) With High Immune Score
Status: UNKNOWN
Conditions: Locally Advanced Rectal Cancer
Interventions: DRUG: Fruquintinib plus Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Everolimus, Carboplatin, and Etoposide in Treating Patients With Small Cell Lung Cancer or Other Advanced Solid Tumors
Status: TERMINATED
Conditions: Lung Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: Carboplatin|DRUG: Etoposide|DRUG: RAD001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated Reduced-Volume Chemoradiation for T1/2N0-2 SCC Head and Neck
Status: TERMINATED
Conditions: Squamous Cell Carcinoma of the Head and Neck T1/2N0-2
Interventions: RADIATION: Intensity Modulated Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-use Versus Reusable Gastroscopes in Patients With Upper Gastrointestinal Bleeding.
Status: RECRUITING
Conditions: Upper Gastrointestinal Bleeding
Interventions: DEVICE: Endoscopic hemostasis using a Esophagogastroduodenoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC