pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Trial to Evaluate Safety, PD & PK of IV Study Drug, QN-302, in Pts w/ Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: QN-302
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Use of Patient Navigation to Promote Timely Diagnostic Evaluation During the COVID-19 Pandemic
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: OTHER: Patient navigator support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Reishi Mushroom Extract for Fatigue and/or Arthralgias/Myalgias in Patients With Breast Cancer on Aromatase Inhibitors
Status: RECRUITING
Conditions: Estrogen Receptor-Positive Breast Carcinoma
Interventions: DIETARY_SUPPLEMENT: Mushroom Extract|DRUG: Placebo Administration|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Compare the Safety and Effectiveness of Genoss® DCB and SeQuent® Please NEO in Chinese Patients With Coronary ISR
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Paclitaxel Coated PTCA Balloon Catheter(Genoss® DCB)|DEVICE: Paclitaxel Coated PTCA Balloon Catheter(SeQuent® Please NEO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: REducing Blood Pressure Variability in Essential Hypertension With RAmipril vErsus Nifedipine GITS Trial
Status: COMPLETED
Conditions: Hypertension|High Blood Pressure Variability
Interventions: DRUG: Nifedipine GITS|DRUG: Ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Dexamethasone With Dexmedetomidine as Additives to Bupivacaine in Adductor Canal Block for Knee Arthroscopy.
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: PROCEDURE: Spinal anaesthesia|PROCEDURE: ultrasound-guided Adductor Canal Block + dexamethasone|PROCEDURE: ultrasound-guided Adductor Canal Block + dexmedetomedine|PROCEDURE: ultrasound-guided Adductor Canal Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vancomycin Or Trimethoprim/Sulfamethoxazole for Methicillin-resistant Staphylococcus Aureus Osteomyelitis
Status: COMPLETED
Conditions: Osteomyelitis|Methicillin-resistant Staphylococcus Aureus
Interventions: DRUG: trimethoprim-sulfamethoxazole|DRUG: vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Creative Arts Program to Reduce Burnout in Healthcare Professionals
Status: RECRUITING
Conditions: Burn-Out Syndrome|Post-Traumatic Stress Disorder|Depression, Anxiety
Interventions: BEHAVIORAL: Visual Arts|BEHAVIORAL: Music|BEHAVIORAL: Dance/Movement|BEHAVIORAL: Writing/Poetry|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sustainable Weight Loss Study: Nutrition Support Tools and Weight Loss Among Obese People
Status: UNKNOWN
Conditions: Obesity
Interventions: BEHAVIORAL: Nutrition and food purchasing tool + telenutrition|BEHAVIORAL: Nutrition and food purchasing tool|BEHAVIORAL: Nutrition education tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of V503 (A Multivalent Human Papillomavirus [HPV] L1 Virus-Like Particle [VLP] Vaccine) in Preadolescents and Adolescents (V503-002)
Status: COMPLETED
Conditions: Cervical Cancers|Vulvar Cancer|Vaginal Cancer|Genital Lesions|PAP Test Abnormalities|HPV Infections
Interventions: BIOLOGICAL: V503
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Pulse Wave and Blood Pressure Measurements Before, During and After Ergometry in Healthy Men
Status: COMPLETED
Conditions: Healthy Male Subjects
Interventions: OTHER: Ergometry H|OTHER: Ergometry L
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of a Nurse-led Continuous Support Program on Neurodevelopment of Preterm Infants
Status: UNKNOWN
Conditions: Preterm Infant
Interventions: BEHAVIORAL: Nurse-led Continuous Support|PROCEDURE: routine follow-up care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Impact of a Targeted Decolonization of S. Aureus Persistent Carriers
Status: RECRUITING
Conditions: Hemodialysis Patients
Interventions: DRUG: Decolonization|OTHER: No decolonization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Utilizing Augmented Reality as an Adjunct for Smoking Cessation
Status: COMPLETED
Conditions: Smoking
Interventions: BEHAVIORAL: Augmented Reality 1|BEHAVIORAL: Augmented Reality 2|BEHAVIORAL: Augmented Reality 3|BEHAVIORAL: Augmented Reality 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Trial to Evaluate The Efficacy Of Rotigotine on Parkinson's Disease-Associated Motor Symptoms And Apathy
Status: COMPLETED
Conditions: Idiopathic Parkinson's Disease
Interventions: DRUG: Rotigotine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Robust Antibody and Cytokine Response to Hepatitis B Vaccine Among Not-in-treatment Patients With Chronic Hepatitis C：An Open-label Control Study in China
Status: COMPLETED
Conditions: Hepatitis B Vaccines
Interventions: BIOLOGICAL: hepatitis B vaccine made by Recombinant DNA Techniques in Saccharomyces Cerevisiae
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Degree of Digestibility of Barley Rice Proteins
Status: COMPLETED
Conditions: Digestive System
Interventions: OTHER: Barley rice protein concentrate shake|OTHER: Pea protein concentrate shake|OTHER: Whey protein concentrate shake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Preliminary Effectiveness of BNT327, an Investigational Therapy for Breast Cancer, When Given in Combination With Chemotherapy
Status: RECRUITING
Conditions: Locally Advanced Breast Cancer|Triple Negative Breast Cancer
Interventions: DRUG: BNT327 Dose Level 1 (DL1)|DRUG: BNT327 Dose Level 1 (DL2)|DRUG: Taxane A|DRUG: Alkylating agent|DRUG: Antimetabolite|DRUG: Taxane B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Lifestyle-induced Hepatic Steatosis on Glucagon-stimulated Amino Acid Turnover
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease|Glucagon Resistance
Interventions: DRUG: Glucagon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: CTPVB for Hepatectomy
Status: COMPLETED
Conditions: Pain Management|Paravertebral Block|Hepatectomy
Interventions: PROCEDURE: Continuous Paravertebral block with ropivacaine|PROCEDURE: Continuous Paravertebral "block" with saline|DRUG: Patient-controlled analgesia with morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fetal Endoscopic Tracheal Occlusion (FETO) for Severe Congenital Diaphragmatic Hernia
Status: RECRUITING
Conditions: Congenital Diaphragmatic Hernia
Interventions: DEVICE: Balt "Goldballoon"
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diabetes and Osteopathic Manipulative Medicine (OMM)
Status: UNKNOWN
Conditions: Type2 Diabetes Mellitus|Osteopathy in Diseases Classified Elsewhere
Interventions: PROCEDURE: OMT Protocol|PROCEDURE: OMT-Sham Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimized Rehabilitation of Older Adults With Hip Fracture and Signs of Cognitive Impairment - Feasibility Study
Status: RECRUITING
Conditions: Hip Fractures|Cognitive Impairment
Interventions: OTHER: Progressive, individualized and structured exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Combination of MLN0128 (TAK-228) and AZD9291 in Advanced EGFR (Epidermal Growth Factor Receptor) Mutation Positive Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Lung Non-Small Cell Carcinoma|Recurrent Lung Non-Small Cell Carcinoma|Stage III Lung Non-Small Cell Cancer AJCC v7|Stage IIIA Lung Non-Small Cell Cancer AJCC v7|Stage IIIB Lung Non-Small Cell Cancer AJCC v7|Stage IV Lung Non-Small Cell Cancer AJCC v7
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Osimertinib|OTHER: Pharmacological Study|DRUG: Sapanisertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blood Pressure Lowering Strategies to Eliminate Hypertension Disparities (BLESSED)
Status: RECRUITING
Conditions: Hypertension
Interventions: BEHAVIORAL: Behavioral: Evidence-based interventions recommended by the 2017 ACC/AHA hypertension clinical guideline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Behavioral Sleep Intervention on Lower Urinary Tract Symptoms in Older Women
Status: RECRUITING
Conditions: Urgency Urinary Incontinence|Nocturia
Interventions: DRUG: Mirabegron 50 MG|BEHAVIORAL: Brief Behavioral Treatment for Insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inotuzumab Ozogamicin and Conventional Chemotherapy In Patients Aged 56 Years and Older With ALL
Status: RECRUITING
Conditions: Precursor Cell Lymphoblastic Leukemia
Interventions: DRUG: Inotuzumab ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genomic Sequencing in Acutely Ill Neonates
Status: COMPLETED
Conditions: Diseases/Diagnoses|Genetic Disease
Interventions: OTHER: Rapid whole genome sequencing (StatSeq)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Innovative Minimally Invasive Options in Treatment of Urinary Problems Related to Prostate Enlargement (BPH) in Men
Status: WITHDRAWN
Conditions: Lower Urinary Tract Symptoms|Benign Prostatic Hyperplasia|Urinary Frequency/Urgency|Urinary Incontinence, Urge|Incontinence, Urinary|Nocturia
Interventions: DEVICE: UroLift as artifical device for prostatic urethral lift.|DEVICE: Embospheres Microspheres as embolic agents for prostate artery embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Glofitamab in Combination With Rituximab (R) Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) in Circulating Tumor (ct)DNA High-Risk Patients With Untreated Diffuse Large B-Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma
Interventions: DRUG: Glofitamab|DRUG: Tocilizumab|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone|DRUG: Rituximab|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Arm Restraint For Critically Ill Patients To Reduce Immobility, Sedation, Agitation and Cognitive Impairment
Status: COMPLETED
Conditions: Acute Respiratory Failure|Encephalopathy|ARDS|Sepsis|Critical Illness
Interventions: DEVICE: Exersides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Derived Neurotropic Factor Response to Aerobic Exercise Intensity in Depressive Patients.
Status: COMPLETED
Conditions: Depressive Disorder|Depressive Disorder, Major
Interventions: BEHAVIORAL: High aerobic intensity training (HIT)|BEHAVIORAL: Long slow distance training (LSD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Immunopharmacology of EDP1815 and EDP2939
Status: COMPLETED
Conditions: KLH and Imiquimod Induced Skin Inflammation in Healthy Volunteers
Interventions: DRUG: EDP1815|DRUG: EDP2939|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Travatan Z and Xalatan on Ocular Surface Health
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: Travoprost ophthalmic solution 0.004% with SofZia® preservative system (TRAVATAN Z®)|DRUG: Latanoprost ophthalmic solution 0.005% (XALATAN®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Two Patterns of Micropulse Laser in the Treatment of Chronic Central Serous Chorioretinopathy
Status: NOT_YET_RECRUITING
Conditions: Central Serous Chorioretinopathy
Interventions: PROCEDURE: 100μm laser spot diameter micropulse laser|PROCEDURE: 200μm laser spot diameter micropulse laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rifamycin SV-MMX® Tablets Versus Ciprofloxacin Capsules in Acute Traveller's Diarrhoea
Status: COMPLETED
Conditions: Traveler's Diarrhea
Interventions: DRUG: Rifamycin SV-MMX®|DRUG: Ciprofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Xenetix 300 in Multislice Computed Tomography (CT) Pediatric Indications
Status: COMPLETED
Conditions: Diagnostic Imaging
Interventions: DRUG: Xenetix|DRUG: Visipaque
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety Study in Subjects With Metastatic Breast Cancer Who Progressed After Taxanes Treatment.
Status: COMPLETED
Conditions: BRMS1|Performance Status Zero to Two for Beginning the Study|Patient With a Maximum of One Chemotherapy|Patient With Progression After Taxanes
Interventions: DRUG: Lapatinib Vinorelbine|DRUG: Lapatinib Capecitabine|DRUG: Gemcitabine Lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of L. Plantarum and P. Acidilactici in Adults With SARS-CoV-2 and COVID-19
Status: COMPLETED
Conditions: SARS-CoV Infection
Interventions: DIETARY_SUPPLEMENT: Probiotics|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Infraorbital Nerve Block for Endoscopic Transsphenoidal Approach to Remove Pituitary Tumor
Status: UNKNOWN
Conditions: Intraoperative Pain Control
Interventions: DRUG: dexmedetomidine 5 mcg mixed with 0.5% plain bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Atomoxetine for ADHD in Adolescents and Young Adults With SUD
Status: WITHDRAWN
Conditions: Attention Deficit Hyperactivity Disorder|Substance Use Disorder
Interventions: DRUG: Atomoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations Results
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DEVICE: Magstim Rapid 2 system triggering Magstim Super Rapid system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Carboxyamidotriazole Orotate (CTO) in Solid Tumors or With Temodar® in Glioblastoma or Other Recurrent Malignant Gliomas or in Combination With Temodar® and Radiation Therapy for Patients With Newly Diagnosed Glioblastoma and Malignant Gliomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumors, Glioblastoma, Recurrent Malignant Gliomas
Interventions: DRUG: CTO|DRUG: CTO and Temodar®|DRUG: CTO, Temodar®, Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesia for Mid-line Laparotomies: Thoracic Epidural vs Restus Sheath Analgesia
Status: UNKNOWN
Conditions: Mid-line Laparotomies
Interventions: DEVICE: Group TEA: thoracic epidural analgesia group|DEVICE: Group RSB: rectus sheath block group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Syngenon (BSG-001) for Inhalation in Subjects With Malignant Pleural Effusion and/or Malignant Ascites
Status: UNKNOWN
Conditions: Malignant Pleural Effusion|Malignant Ascites
Interventions: DRUG: BSG-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Prospective, oBservational Study to assEss the Clinical activitY and Impact on symptOm Burden and patieNts' HRQoL of Treatment With trabecteDin in aSTS in a Real World Setting in Greece
Status: COMPLETED
Conditions: Advanced Soft Tissue Sarcoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Green Tea Extract in Treating Patients With Monoclonal Gammopathy of Undetermined Significance and/or Smoldering Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm|Precancerous Condition
Interventions: DIETARY_SUPPLEMENT: defined green tea catechin extract|GENETIC: gene expression analysis|GENETIC: protein analysis|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D Supplement on Osteoprotegin Expression and Disease Progression in Patients With Chronic Kidney Disease Stage 1 and 2
Status: UNKNOWN
Conditions: Chronic Kidney Disease Stage 1|Chronic Kidney Disease Stage 2
Interventions: DRUG: Calcitriol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacodynamic Study of the Effect of INCB013739 on Insulin Sensitivity in Obese, Type 2 Diabetic Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Obesity
Interventions: DRUG: Placebo|DRUG: INCB013739
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the NDO Endoscopic Plication System For the Treatment of Symptomatic Gastroesophageal Reflux Disease
Status: COMPLETED
Conditions: GERD
Interventions: DEVICE: NDO Full-thickness Plicator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase IV Study to Evaluate Calcineurin Inhibitor Reduced, Steroid Free Immunosuppression After Renal Transplantation
Status: COMPLETED
Conditions: Disorder Related to Renal Transplantation
Interventions: DRUG: Basiliximab, Tacrolimus, MMF, Prednisolon|DRUG: Basiliximab, Tacrolimus, MMF|DRUG: Tacrolimus, MMF, rATG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Donepezil Attenuate Postoperative Cognitive Dysfunction
Status: UNKNOWN
Conditions: Osteoarthritis|Femoral Head Necrosis|Rheumatoid Arthritis
Interventions: DRUG: Donepezil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Toripalimab Combined With Chemotherapy as Neoadjuvant Treatment of Gastric Cancer
Status: RECRUITING
Conditions: Gastric Cancer Stage II|Gastric Cancer Stage III
Interventions: DRUG: Toripalimab|DRUG: oxaliplatin|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Postprandial Glycemic and Insulinemic Response After a Fibersym Containing Cookie With a Control
Status: COMPLETED
Conditions: Postprandial Hyperglycemia
Interventions: OTHER: Fibersym|OTHER: Control cookie
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effectiveness of Cognitive Remediation Therapy in Improving Treatment Retention in People With Anorexia Nervosa
Status: COMPLETED
Conditions: Anorexia Nervosa
Interventions: BEHAVIORAL: Cognitive remediation therapy (CRT)|BEHAVIORAL: Cognitive behavioral therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hepatic Energy Fluxes in NASH and NAS Patients
Status: RECRUITING
Conditions: NASH - Nonalcoholic Steatohepatitis|NAS|Overweight or Obesity|Weight Loss|Bariatric Surgery Candidate
Interventions: PROCEDURE: Vertical Sleeve Gastrectomy (VSG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aqueous vs Alcohol Chlorhexidine Skin Preparation for Prevention of Cesarean Section Wound Infections
Status: RECRUITING
Conditions: Surgical Site Infection|Cesarean Section; Infection
Interventions: DRUG: 2% Chlorhexidine gluconate with 70% alcohol|DRUG: 4% Chlorhexidine Gluconate aqueous solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Satisfaction of Patients and Care Providers for an Alternate Follow-up With In-hospital Consults and Tele-consult for Patients With Cystic Fibrosis
Status: RECRUITING
Conditions: Cystic Fibrosis
Interventions: OTHER: Follow-up alternating between face-to-face consultation and teleconsultation every three months.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Use of Levonorgestrel-Releasing Device (Metraplant-E) in the Treatment of Dysfunctional Uterine Bleeding
Status: COMPLETED
Conditions: Dysfunctional Uterine Bleeding
Interventions: DEVICE: Metraplant-E levonorgestrel-releasing intrauterine device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation Versus Virtual Reality on Gait in Children With Spastic Diplegia
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DEVICE: Transcranial direct current stimulation|DEVICE: Virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: This Study is to Compare the Efficacy of ZD6474 and ZD1839 in Subjects With NSCLC.
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: ZD6474|DRUG: Placebo|DRUG: ZD1839
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A 5-Period, Single Dose, Phase 1 Study in Healthy Elderly Subjects to Assess Relative Bioavailability and Food Effect of Two Oral Formulations of GSK1325756 (Free Base vs HBr Salt) and Food Effect on the HBr Formulation When Given With Omeprazole
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Danirixin HBr 50 mg IR Tablet|DRUG: Danirixin FB 50 mg IR Tablet|DRUG: Prilosec (omeprazole) 40mg Delayed-Release capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Probiotics and Antibiotic-Associated Diarrhea
Status: COMPLETED
Conditions: Antibiotic-associated Diarrhea
Interventions: DRUG: Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet|BIOLOGICAL: BB-12|OTHER: Control Yogurt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Dose Ranging Study to Assess Efficacy, Safety, Tolerability and Pharmacokinetics of PF-06700841 Topical Cream in Participants With Mild or Moderate Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: PF-06700841|DRUG: Vehicle (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation the Effect of Using of Apical Matrix With Apexification Procedure on Apical Healing of Necrotic Immature Teeth
Status: COMPLETED
Conditions: Pulp Necrosis|Apexification
Interventions: PROCEDURE: Apexification|DRUG: MTA|DRUG: Ca(OH)2|DRUG: Apical matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is Left Stellate Ganglionectomy Beneficial to Patients With Life Threatening Ventricular Arrhythmias
Status: WITHDRAWN
Conditions: Sudden Cardiac Death
Interventions: PROCEDURE: Left cardiac sympathetic denervation|PROCEDURE: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ipilimumab and Local Radiation for Selected Solid Tumors
Status: TERMINATED
Conditions: Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Peripheral T-cell Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Colon Cancer|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Melanoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Rectal Cancer|Recurrent Small Lymphocytic Lymphoma|Refractory Hairy Cell Leukemia|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|T-cell Large Granular Lymphocyte Leukemia|Testicular Lymphoma|Waldenström Macroglobulinemia
Interventions: BIOLOGICAL: Ipilimumab|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Ervebo® and Zabdeno® Booster Vaccines Against Ebola Virus Following Previous Vaccination With the Zabdeno/Mvabea® or Ervebo® Vaccine Schedules in DRC
Status: NOT_YET_RECRUITING
Conditions: Ebola Virus Disease
Interventions: DRUG: Zabdeno® booster|DRUG: Ervebo® booster
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Open-label Dose-finding Trial of OPC-41061 in Patients With Chronic Renal Failure Undergoing Peritoneal Dialysis
Status: COMPLETED
Conditions: Chronic Renal Failure
Interventions: DRUG: OPC-41061
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial to Evaluate Ampyra for Gait Impairment in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Ampyra first, then Placebo|DRUG: placebo first, then Ampyra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bupropion Alone or Combined With Nicotine Gum
Status: COMPLETED
Conditions: Tobacco Dependence
Interventions: DRUG: bupropion + nicotine gum|DRUG: Active bupropion-Placebo gum|DRUG: Placebo bupropion-Placebo gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy Plus Interleukin-2 in Treating Patients With Stage III or Stage IV Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: gp100 antigen|BIOLOGICAL: incomplete Freund's adjuvant|BIOLOGICAL: sargramostim|BIOLOGICAL: tetanus peptide melanoma vaccine|BIOLOGICAL: tyrosinase peptide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Daxdilimab (HZN-7734) in Patients With Moderate-to-Severe Primary Discoid Lupus Erythematosus
Status: RECRUITING
Conditions: Discoid Lupus Erythematosus
Interventions: DRUG: Placebo/Daxdilimab|DRUG: Daxdilimab|DRUG: Daxdilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Telehealth Rapid Intervention for Externalizing Behaviors in ASD
Status: ENROLLING_BY_INVITATION
Conditions: Autism Spectrum Disorder|Disruptive Behavior|Externalizing Behavior|Parent-Child Interaction Therapy|Telehealth
Interventions: BEHAVIORAL: Tele-PCIT|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vincristine, DOXIL (Doxorubicin HCl Liposome Injection) and Dexamethasone vs. Vincristine, Doxorubicin, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma|Myeloma|M-Protein|Myeloma Proteins
Interventions: DRUG: Vincristine, DOXIL (doxorubicin HCl liposomal injection), and Dexamethasone (VDD) vs. Vincristine, Doxorubicin and Dexamethasone (VAD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block Versus Opioid Based General Anesthesia During Laparoscopic Bariatric Surgery
Status: COMPLETED
Conditions: Bariatric Surgery Candidate|Morbid Obesity|Visceral Pain
Interventions: PROCEDURE: bilateral ultrasound guided erector spinae plane block|DRUG: Nalbuphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of TQB2450 Injection in Subjects With Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma
Status: TERMINATED
Conditions: Relapsed or Refractory Primary Mediastinal B-cell Lymphoma (rrPMBCL)
Interventions: DRUG: TQB2450
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Non-Caloric Artificial Sweeteners on Youth With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DIAGNOSTIC_TEST: Bioelectrical Impedance Analysis|DIAGNOSTIC_TEST: Total Body Dual-energy X-ray Absorptiometry|DIAGNOSTIC_TEST: Blood draw
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comprehensive Electronic Cancer Support System for the Treatment of Cancer Related Symptoms
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Primary Liver Cancer|Bile Duct Cancer|Pancreatic Cancer|Gallbladder Cancer|Colorectal Carcinoma|Liver Metastases
Interventions: OTHER: Collaborative Care|OTHER: Enhanced usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of the Functional Hand Splint and Specific Tasks in the Domiciliary Environment Applied to Children With Unilateral Cerebral Palsy
Status: COMPLETED
Conditions: Hemiplegia and Hemiparesis|Cerebral Palsy Infantile
Interventions: DEVICE: Home-based protocol in specific tasks|DEVICE: Upper-limb splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antisense Therapy to Block the Kallikrein-kinin Pathway in COVID-19
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: ISIS 721744|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Tolerability of Diclofenac Potassium Soft Gelatin Capsules Compared With Ibuprofen Tablets in Patients With Moderate to Severe Postoperative Dental Pain
Status: COMPLETED
Conditions: Post Operative Dental Pain
Interventions: DRUG: Diclofenac potassium|DRUG: Ibuprofen|DRUG: Placebo to ibuprofen|DRUG: Placebo to diclofenac potassium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A PET Study of the Effects of p38 MAP Kinase Inhibitor, VX-745, on Amyloid Plaque Load in Alzheimer's Disease (AD)
Status: COMPLETED
Conditions: Alzheimer's Disease|Mild Cognitive Impairment
Interventions: DRUG: VX-745
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Low Intensity Therapeutic Ultrasound on Endothelial Function
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Low intensity therapeutic ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of MAb-3F8 Plus Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Versus 13-cis-Retinoic Acid (RA) Plus GM-CSF in Primary Refractory Neuroblastoma Patients
Status: TERMINATED
Conditions: Primary Refractory Neuroblastoma
Interventions: BIOLOGICAL: MAb-3F8|BIOLOGICAL: Subcutaneous Granulocyte Macrophage Colony Stimulating Factor (GM-CSF)|BIOLOGICAL: 13-cis-Retinoic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD38-targeted Chimeric Antigen Receptor T Cell (CART) in Relapesd or Refractory Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: CART-38
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Ivabradine on Heart Rate and Quality of Life in Patients With Mitral Stenosis in Sinus Rhythm
Status: COMPLETED
Conditions: Mitral Stenosis
Interventions: DRUG: Ivabradine|DRUG: Beta blocker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Medical Physics Direct Patient Care for the Improvement of Patient Understanding of Care
Status: COMPLETED
Conditions: Malignant Neoplasm
Interventions: OTHER: Informational Intervention|OTHER: Counseling|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Probiotic and Colchicine in COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Colchicine 0.5 MG|DIETARY_SUPPLEMENT: Probiotic Formula|OTHER: Standard protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Microcurrent Therapy and Low-Level Laser Therapy on Wound Healing
Status: UNKNOWN
Conditions: Wound Healing Delayed
Interventions: DEVICE: Microcurrent therapy|DEVICE: Low Level Laser Therapy|OTHER: Medical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Subacromial Shoulder Pain by Individual or Group Physiotherapy Following Corticosteroid Injection
Status: COMPLETED
Conditions: Shoulder Pain|Rotator Cuff Impingement
Interventions: OTHER: Rotator cuff rehabilitation classes|OTHER: Individual Physiotherapy|DRUG: Triamcinolone Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Predictive Factors in Chronic Rhinosinusitis With Nasal Polyps
Status: NOT_YET_RECRUITING
Conditions: Chronic Rhinosinusitis With Nasal Polyps
Interventions: DIAGNOSTIC_TEST: Serum IL_25 and eosinophils in nasal polyp tisuee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Accuracy of Amniotic Fluid Lamellar Body Counting for Evaluating of Fetal Lung Maturity
Status: COMPLETED
Conditions: Retained Fetal Lung Fluid
Interventions: OTHER: Amniotic fluid Lamellar Body Counting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Supramaximal High-Intensity Interval Training in People With and Without Chronic Obstructive Pulmonary Disease
Status: RECRUITING
Conditions: COPD|Healthy Controls
Interventions: OTHER: Exercise training on a stationary bicycle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab With Pemetrexed and Oxaliplatin in Chemo-Refractory Metastatic Colorectal Cancer Patients
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Pemetrexed|DRUG: Oxaliplatin|DRUG: Dexamethasone|DIETARY_SUPPLEMENT: Folic Acid|DIETARY_SUPPLEMENT: Vitamin B-12
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OPtical Frequency Domain Imaging Versus INtravascular Ultrasound in Percutaneous Coronary InterventiON - OPINION Imaging
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: OFDI-guided PCI & IVUS|DEVICE: IVUS-guided PCI & OFDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes After Dorsal Wrist Ganglia Excision With or Without PIN
Status: ENROLLING_BY_INVITATION
Conditions: Wrist Ganglion|Ganglion Cysts|Hand Ganglion|Denervation Atrophy
Interventions: PROCEDURE: Dorsal wrist ganglion alone (DWG)|PROCEDURE: DWG/PIN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetic and Microbiological Investigation of GSK3882347 in Female Participants With Urinary Tract Infections
Status: RECRUITING
Conditions: Uncomplicated Urinary Tract Infections|Urinary Tract Infections
Interventions: DRUG: GSK3882347|DRUG: Nitrofurantoin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: M-Tapa Block for Laparoscopic Inguinal Hernia Repair Surgery
Status: COMPLETED
Conditions: Hernia, Inguinal
Interventions: DRUG: M TAPA block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Treatment of Patients With High Risk of Recurrent Hepatocellular Carcinoma With Donafenib in Combination With Envafolimab
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Donafenib + Envafolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stretching of the Diaphragm and Cervical Impulse Technique and Its Possible Spirometric Changes
Status: COMPLETED
Conditions: Respiratory Disease
Interventions: PROCEDURE: Stretching the diaphragm muscle|PROCEDURE: Impulse technique in rotation of cervical level 3 and 4|PROCEDURE: Combined technique of diaphragm muscle stretch and cervical rotation impulse technique level 3 and 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Standard vs. Accelerated Initiation of RRT in Acute Kidney Injury (STARRT-AKI: Principal Trial)
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: OTHER: Standard RRT initiation|OTHER: Accelerated RRT initiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Speaking Valve Influence on Breathing, Swallowing and Vocal Functions in Patients With Tracheostomy.
Status: RECRUITING
Conditions: Tracheostomy
Interventions: DEVICE: Shiley™ phonate speaking valve|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Safety and Immunogenicity of a Live Attenuated Virus Vaccine for the Prevention of H2N3 Influenza
Status: COMPLETED
Conditions: Influenza A Virus Infection
Interventions: BIOLOGICAL: H2N3 MO 2003/AA ca Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ATHN 2: Factor Switching Study
Status: COMPLETED
Conditions: Hemophilia
Interventions: BIOLOGICAL: Factor VIII Replacement Products for Hemophilia which were FDA approved after January 1, 2013|BIOLOGICAL: Factor IX Replacement Products for Hemophilia which were FDA approved after January 1, 2013
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Free From Maintenance Drug Therapy in Multiple Myeloma (The FREEDMM Trial) for Minimal Residual Disease (MRD
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: OTHER: Discontinue maintenance therapy SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docosaexahenoic Acid and Gross Motor Milestones in Infants
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Docosahexaenoic acid (DHA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Acute Management of Humeral Shaft Fractures: Sling vs. Splint
Status: COMPLETED
Conditions: Fracture of Shaft of Humerus
Interventions: DEVICE: Sling and Swathe|DEVICE: Coaptation Splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability,Pharmacokinetics(PK)and Pharmacodynamics(PD)Assessment of LCQ908 in Patients With Severe Hypertriglyceridemia
Status: COMPLETED
Conditions: Hyperlipoproteinemia
Interventions: DRUG: LCQ908|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Dietary Flavanols on the Gut Microflora
Status: COMPLETED
Conditions: Intestinal Bacteria Growth
Interventions: DIETARY_SUPPLEMENT: Low flavanol cocoa beverage|DIETARY_SUPPLEMENT: High flavanol cocoa beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE