pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase III Study of NPO-11 in Patients Undergoing Therapeutic Upper Gastrointestinal Endoscopy
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: Menthol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Trial of Treat and Extend Aflibercept for Macular Edema Secondary to Branch Retinal Vein Occlusion
Status: UNKNOWN
Conditions: Branch Retinal Vein Occlusion With Macular Edema
Interventions: DRUG: Intravitreal aflibercept injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Preliminary Comparison of the Blood Levels of Medications in Obese Subjects Compared to Post-Gastric Bypass Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: PROCEDURE: bariatric surgery|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Measure Pain Perception Following De-Epithelized Free Gingival Graft Harvesting
Status: COMPLETED
Conditions: Gingival Recession|Palate; Wound
Interventions: DIAGNOSTIC_TEST: palatal wound will be cover with collagen and sutures|DIAGNOSTIC_TEST: palatal wound covered with platelet rich fibrin|DIAGNOSTIC_TEST: palatal wound covered with a collagen sponge and cyanoacrylate|DIAGNOSTIC_TEST: palatal wound covered with a stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Focal MR-Guided Focused Ultrasound Treatment of Localized Low-Intermediate Risk Prostate Cancer: Feasibility Study
Status: COMPLETED
Conditions: Localized Low-Intermediate Risk Prostate Cancer
Interventions: DEVICE: MRgFUS Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sinus Lift With Hydroxyapatite Nano Particles Versus Tenting Technique
Status: UNKNOWN
Conditions: Maxillary Sinus Lift
Interventions: PROCEDURE: sinus lift implant placement Hydroxyapatite Nano particles|PROCEDURE: sinus lift implant placement tenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Efficacy of CR8020 and CR6261, Monoclonal Antibodies, Against Influenza Infection
Status: WITHDRAWN
Conditions: Influenza
Interventions: BIOLOGICAL: CR8020|BIOLOGICAL: CR6261|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tumor Treating Fields (TTFields, 150 kHz) Concomitant With Chemotherapy as First Line Treatment of Unresectable Gastroesophageal Junction or Gastric Adenocarcinoma
Status: UNKNOWN
Conditions: Gastric Cancer|GastroEsophageal Cancer
Interventions: DEVICE: NovoTTF-100L(P)|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Early Changes Visible to the Diffusion MRI in Response to Two Years of Treatment With Tysabri in Patients With Multiple Sclerosis
Status: TERMINATED
Conditions: Multiple Sclerosis
Interventions: RADIATION: Diffusion Magnetic Resonance Imaging at 6 months
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Decreasing Infection In Arthroscopic Shoulder Surgery
Status: COMPLETED
Conditions: Post Operative Infection Arthroscopic Shoulder Surgery|Infection
Interventions: DRUG: Benzoyl Peroxide solution Plus Chlorhexidine Scrub|OTHER: Standard of Care - Chlorhexidine Scrub only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Pharmacokinetics of Dexlansoprazole 30 Milligram (mg) and 60 mg Delayed-release Capsules in Healthy Chinese Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Dexlansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Versus Oral Acetaminophen in Primary Total Hip Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis|Acetaminophen|Arthroplasty, Hip Replacement
Interventions: DRUG: Intravenous acetaminophen|DRUG: Oral acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cost-effectiveness of Implant Treatment for the Edentulous Mandible
Status: COMPLETED
Conditions: Edentulous Mouth
Interventions: DEVICE: Single-implant mandibular overdenture|DEVICE: Two-implant mandibular overdenture|DEVICE: Fixed mandibular denture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Breast Cancer Biomarkers Using Synergistic Prostaglandin Inhibitors
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Celecoxib|DRUG: Placebo|DRUG: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Short Arm Human Centrifuge Therapeutic Training and Rehabilitation (GRACER1)
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis|Stroke|Pulmonary Disease, Chronic Obstructive|Aged
Interventions: DEVICE: ARTIFICIAL GRAVITY COMBINED WITH EXERCISE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 3-AP and Cisplatin in Treating Patients With Recurrent or Persistent Platinum-Resistant Ovarian Epithelial or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer
Interventions: DRUG: triapine|DRUG: cisplatin|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Augmentation of Keratinized Tissue Around Dental Implant With a Xenogeneic Collagen Matrix and the Free Gingival Graft
Status: COMPLETED
Conditions: Inadequately Attached Gingiva
Interventions: PROCEDURE: apically repositioned flap+ xenogeneic collagen matrix +free gingival graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Haemodynamic Changes After Spinal Anaesthesia in Non-obese and Pregnant Women
Status: COMPLETED
Conditions: Low Cardiac Output
Interventions: DEVICE: LiDCOrapid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Systolic Cardiomyopathy (Aim2)
Status: COMPLETED
Conditions: Cardiomyopathy|Renal Impairment
Interventions: DRUG: Tadalafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Does Intense Regimented Surveillance Improve the Rates of Therapeutic Re-Intervention After Lung Cancer Surgery
Status: COMPLETED
Conditions: Lung Neoplasms
Interventions: PROCEDURE: Low Dose Computed Tomography Imaging|PROCEDURE: Chest Radiograph Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Study to Investigate the Immune Response to Influenza Vaccine in Patients With Multiple Sclerosis on Teriflunomide
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: teriflunomide|DRUG: Interferon-β-1|BIOLOGICAL: Influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A Study to Evaluate the Effects of Multiple Doses of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Placebo (Part A)|DRUG: CK-2017357 (Part A)|DRUG: CK-2017357 (Part A)|DRUG: CK-2017357 (Part A)|DRUG: Riluzole 50 MG (Part B)|DRUG: Placebo (Part B)|DRUG: CK-2017357 (Part B)|DRUG: CK-2017357 (Part B)|DRUG: CK-2017357 (Part B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Efficacy of Urinary and Recombinant Human Chorionic Gonadotropin (hCG) on Oocyte Maturity
Status: COMPLETED
Conditions: In Vitro Fertilization
Interventions: DRUG: recombinant hCG|DRUG: recombinant hCG|DRUG: urinary hCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Exercise on Post-traumatic Stress Disorder and Sleep Quality in Individuals Affected by the 2023 Kahramanmaraş Earthquakes
Status: COMPLETED
Conditions: Earthquake|Stress Disorders, Post-Traumatic
Interventions: OTHER: Exercise|OTHER: lifestyle advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Bromopride and Simethicone Versus Bromopride in Functional Dyspepsia
Status: COMPLETED
Conditions: Dyspepsia
Interventions: DRUG: FDC Bromopride 10 mg and Simethicone 80 mg|DRUG: Bromopride 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intraileal Glucose vs. Saline Infusion on Hormone Secretion and Glycemic Excursions
Status: COMPLETED
Conditions: Incretins
Interventions: DIETARY_SUPPLEMENT: intraileal infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Getting SMART for Pediatric Epilepsy
Status: RECRUITING
Conditions: Epilepsy in Children
Interventions: DRUG: Melatonin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Duloxetine Versus Placebo in Chronic Low Back Pain
Status: COMPLETED
Conditions: Back Pain Without Radiation
Interventions: DRUG: Duloxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Niacin on Hyperphosphatemia in Patients Undergoing Haemodialysis
Status: UNKNOWN
Conditions: Hyperphosphatemia
Interventions: DRUG: Niacin|DRUG: Phosphate Binder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Antenatal Steroid on Pulmonary Artery Blood Flow
Status: UNKNOWN
Conditions: Neonatal Respiratory Distress
Interventions: DRUG: Betamethasone|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Cytotect®CP, Hyperimmune Anti-CMV IVIg as CMV Prophylaxis in Patients Developing Acute Grade II-IV GVHD After Allogeneic Hematopoietic Cell Transplantation.
Status: RECRUITING
Conditions: Cytomegalovirus Infections
Interventions: DRUG: Cytotect®CP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Administration of Lugols Solution in Toxic Thyroid Diseases (TD): A Prospective Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Toxic; Thyroid
Interventions: DIETARY_SUPPLEMENT: Lugol's iodine solution 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Minocycline as Neuroprotectant After Aneurysmal Subarachnoid Hemorrhage
Status: WITHDRAWN
Conditions: Subarachnoid Aneurysm Hemorrhage
Interventions: DRUG: Minocycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SH-1028 Tablets Versus Placebo as Adjuvant Therapy in Resected Stage II-IIIB NSCLC With Sensitizing EGFR Mutations
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: SH-1028 tablets|DRUG: Placebo SH-1028 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Videolaryngoscopy vs Direct Laryngoscopy for Intubation in Patients With Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: Videolaryngoscopy|DEVICE: Direct laryngoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Eculizumab in Patients With Mild Allergic Asthma
Status: COMPLETED
Conditions: Allergic Asthma
Interventions: DRUG: eculizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Safety and Effectiveness of Stomaphyx for Transoral Incisionless Reduction of the Enlarged Gastric Pouch and Stoma
Status: COMPLETED
Conditions: Morbid Obesity
Interventions: DEVICE: StomaphyX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Interleukin-15 in Treating Patients With Advanced Melanoma, Kidney Cancer, Non-small Cell Lung Cancer, or Squamous Cell Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma|Recurrent Head and Neck Carcinoma|Recurrent Non-Small Cell Lung Carcinoma|Recurrent Renal Cell Carcinoma|Recurrent Skin Carcinoma|Stage III Renal Cell Cancer|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIA Non-Small Cell Lung Cancer AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIB Non-Small Cell Lung Cancer AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7|Stage IV Non-Small Cell Lung Cancer AJCC v7|Stage IV Renal Cell Cancer
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|BIOLOGICAL: Recombinant Human Interleukin-15
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Kidney Recovery After Acute Kidney Injury Receiving Dialysis
Status: RECRUITING
Conditions: Acute Kidney Injury
Interventions: OTHER: Standardized Dialysis and Structured Discontinuation (S2D2)|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Pregnant Women With Placenta Previa
Status: RECRUITING
Conditions: Hemorrhage, Postpartum|Placenta Previa
Interventions: DRUG: Tranexamic acid|OTHER: 0.9% sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Virucidal Effect of Povidone Iodine on COVID-19 In-Vivo
Status: COMPLETED
Conditions: COVID19
Interventions: DRUG: Povidone-Iodine 0.4% NI|DRUG: Povidone-Iodine 0.5% NI|DRUG: Povidone-Iodine 0.6% NI|DRUG: Povidone-Iodine 0.5% NS|DRUG: Povidone-Iodine 0.6% NS|OTHER: Placebo comparator: DW-NI|OTHER: Placebo comparator: DW-NS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mindfulness-based Cognitive Therapy for Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)|Chronic Obstructive Lung Disease|Chronic Obstructive Airway Disease|Chronic Bronchitis|Emphysema
Interventions: BEHAVIORAL: Mindfulness-based cognitive therapy|BEHAVIORAL: Pulmonary rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Immunogenicity Study of a Candidate Tuberculosis Vaccine in Human Immunodeficiency Virus (HIV)-Positive Adults
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: GSK's investigational vaccine 692342|BIOLOGICAL: Physiological saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Improving Hand Motor Function After Stroke: Role of Robotics
Status: COMPLETED
Conditions: It is Possible That Amadeo Will Guarantee a Greater Clinical Improvement as Compared to an Occupational Therapy Thanks to the Strengthening of Brain Plasticity
Interventions: DEVICE: Amadeo Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of Ambu® aScope for Intubation in Cancer Tongue
Status: COMPLETED
Conditions: Difficult Intubation
Interventions: DEVICE: ambu ascope|DEVICE: fibreroptic bronchoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Physiological Umbilical Cord Clamping in Patients With Congenital Diaphragmatic Hernia. Clinical Trial
Status: RECRUITING
Conditions: Umbilical Cord Clamping|Congenital Diaphragmatic Hernia|Delayed Umbilical Cord Separation
Interventions: PROCEDURE: Physiological cord clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Safety and Efficacy of Keratin Hair Therapy
Status: UNKNOWN
Conditions: Hair Damage
Interventions: PROCEDURE: Keratin hair treatment (Keratin Cure ®) versus (QOD Max ®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Cell Therapy to Enhance Arthroscopic Knee Cartilage Surgery
Status: COMPLETED
Conditions: Articular Cartilage Defect Grade III or IV of the Knee
Interventions: PROCEDURE: Autologous Cell|PROCEDURE: Standard microfracture arthroscopic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized Spine Study Group Registry
Status: WITHDRAWN
Conditions: Scoliosis; Adolescence|Degenerative Disc Disease|Spinal Fusion|Kyphoscoliosis|Pseudoarthrosis of Spine|Spinal Stenosis|Kyphoses, Scheuermann
Interventions: DEVICE: Patient Specific Rod
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Activity of NCO-48 Fumarate in Treatment-Naive Adults With Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: NCO-48 Fumarate 4 mg|DRUG: NCO-48 Fumarate 20 mg|DRUG: Tenofovir Alafenamide 25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serum Nesfatin-1 and Human Cartilage Glycoprotein-39 Levels in Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis of Knee|Degenerative Osteoarthritis
Interventions: BEHAVIORAL: exercise|BIOLOGICAL: intraarticular knee PRP injections
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetic Profiles of Two Formulations of CO-1.01 in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumor
Interventions: DRUG: CO-1.01 Formulation A (Aqueous suspension containing 15 mg/mL of drug solubilized in purified phospholipids)|DRUG: CO-1.01 Formulation B (Aqueous suspension containing 30 mg/mL of drug solubilized in purified phospholipids)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of HuZhen Capsule for Treatment of Patients With Acute Gout
Status: UNKNOWN
Conditions: Acute Gout
Interventions: DRUG: HuZhen Capsule|DRUG: Placebo Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Palliative Care for Patients With Multiple Myeloma and Aggressive Lymphoma
Status: RECRUITING
Conditions: Multiple Myeloma in Relapse|Multiple Myeloma, Refractory|Multiple Myeloma Stage III|Multiple Myeloma Progression|Multiple Myeloma|B Cell Lymphoma|Lymphoma, B-Cell|Aggressive Lymphoma
Interventions: OTHER: Early Palliative Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety Study of BJ-001, an IL-15 Fusion Protein, for Locally Advanced/Metastatic Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced/Metastatic Solid Tumors
Interventions: DRUG: BJ-001|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Pilot Shard-care Program for Patients With Chronic Pain in the Champlain-LHIN
Status: UNKNOWN
Conditions: Chronic Pain|Quality of Life
Interventions: BEHAVIORAL: Online Chronic Pain Management Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 18F-Fluoride Assessment of Aortic Bioprosthesis Durability and Outcome
Status: COMPLETED
Conditions: Heart; Complications, Valve, Prosthesis
Interventions: RADIATION: 18F-Fluoride PET-CT|RADIATION: CT calcium score of aortic valve
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Brown Fat Activation Study
Status: COMPLETED
Conditions: Obese|Metabolic Syndrome
Interventions: DRUG: Mirabegron|DRUG: Pioglitazone|DRUG: Mirabegron and Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Morphine Titration by Patient Self-controlled by a Mechanical Device Versus Administration by the Nurse for Patients With Severe Acute Pain in the Emergency Department
Status: COMPLETED
Conditions: Acute Pain
Interventions: DEVICE: Titration of morphine by Patient Controlled Analgesy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Progesterone and Atomoxetine for Cocaine Cessation
Status: WITHDRAWN
Conditions: Cocaine Dependence|Nicotine Dependence
Interventions: DRUG: Progesterone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Designed to See How [14C]-CORT125134 is Taken up, Broken Down and Removed From the Body
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: [14C]-CORT125134
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study on the Efficacy of Virtual Reality Exposure Therapy (VRET) for Survivors of Childhood Sexual Abuse and War Related Trauma
Status: UNKNOWN
Conditions: Posttraumatic Stress Disorder (PTSD)|Depression
Interventions: BEHAVIORAL: VRET|BEHAVIORAL: TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Double Blind, Randomized, Controlled Study to Evaluate CHF 5633 (Synthetic Surfactant) and Poractant Alfa in Neonates With Respiratory Distress Syndrome (RDS) (POC)
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Newborn
Interventions: DRUG: CHF5633|DRUG: Poractant alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effect of Perineural Fentanyl Additive to Local Anesthetics in Femoral Nerve Block
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: rocaine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Crystalloid Versus Colloid Rapid Co-load for Cesarean Delivery Under Spinal Anesthesia
Status: COMPLETED
Conditions: Pregnancy|Cesarean Delivery|Hypotension
Interventions: OTHER: Crystalloid|OTHER: Colloid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Considering Racial and Acculturation Stress in Addressing Trauma
Status: RECRUITING
Conditions: Trauma-related PTSD
Interventions: BEHAVIORAL: Trauma Focused CBT (TF-CBT)|BEHAVIORAL: Trauma Systems therapy (TST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Diabetes Medication Adherence for African Americans in Madison and Milwaukee Through Peer Support
Status: COMPLETED
Conditions: Type2 Diabetes|Medication Adherence|Medication Nonadherence|Peer Support
Interventions: BEHAVIORAL: Peers Supporting Health-Literacy, Self Efficacy, Advocacy and Adherence
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Insulin Versus Hyaluronic Acid in Management of Periodontal Defects
Status: RECRUITING
Conditions: Periodontal Diseases|Periodontal Pocket
Interventions: DRUG: Insulin|DRUG: Hyaluronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GLU-xx Formulations in Individuals With Impaired Glucose Tolerance
Status: TERMINATED
Conditions: Impaired Glucose Tolerance
Interventions: DIETARY_SUPPLEMENT: GLU-01|DIETARY_SUPPLEMENT: GLU-02|DIETARY_SUPPLEMENT: GLU-03|DIETARY_SUPPLEMENT: GLU-04|DIETARY_SUPPLEMENT: GLU-05|DIETARY_SUPPLEMENT: GLU-06
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Retifanlimab (INCMGA00012) and Telotristat Ethyl for the Treatment of Advanced Neuroendocrine Tumors and Carcinoid Syndrome
Status: WITHDRAWN
Conditions: Advanced Neuroendocrine Neoplasm|Carcinoid Syndrome
Interventions: BIOLOGICAL: Retifanlimab|DRUG: Telotristat Ethyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selinexor in Combination With Fludarabine and Cytarabine in Patients With Refractory or Relapsed Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: Selinexor|DRUG: Fludarabine|DRUG: Cytarabine|DRUG: methotrexate/hydrocortisone/cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caries Prevention Products & Dentinal Hypersensitivity
Status: COMPLETED
Conditions: Hypersensitivity
Interventions: DEVICE: Sensodyne|DEVICE: Crest Cavity Protection & MI Paste Plus|DEVICE: Clinpro 5000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Flexibility in Major Depression in the Course of Pharmacological and Psychotherapeutic Treatment
Status: COMPLETED
Conditions: Cognitive Performance in Major Depression
Interventions: DRUG: citalopram|DRUG: reboxetine|BEHAVIORAL: interpersonal psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Effectiveness of Eye90 Microspheres™ in the Treatment of Unresectable HCC and mCRC
Status: COMPLETED
Conditions: Hepatocellular Carcinoma Non-resectable|Metastatic Colorectal Cancer|Liver Cancer
Interventions: DEVICE: Eye90 Microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Mini Squat and Endurance Training in Improving Quality of Life in Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Mini Squats Training|OTHER: Endurance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Endovenous Laser Ablation in Acute Thrombophlebitis of the Varicose Great Saphenous Vein
Status: COMPLETED
Conditions: Superficial Vein Thrombosis|Endovenous Laser Ablation
Interventions: PROCEDURE: Endovenous laser ablation|DRUG: Fondaparinux Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Safety and Efficacy Study of a Vitamin D Compound (DP001) in Postmenopausal Women With Low Bone Mineral Density
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Placebo|DRUG: DP001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Immunogenicity of FluvalAB-like Influenza Vaccine in Non-Elderly Adult and Elderly Subjects
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Vaccination with FAB-6011|BIOLOGICAL: Vaccination with FluvalAB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: An 18 Week Efficacy and Safety Study of Saxagliptin and Metformin XR Combination in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Saxagliptin|DRUG: Metformin XR|DRUG: Metformin XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lurbinectedin Combined With Durvalumab in Pre-treated Patients With Extensive Stage Small-cell Lung Cancer
Status: WITHDRAWN
Conditions: Small Cell Lung Cancer|Platinum-Sensitive Lung Small Cell Carcinoma|Extensive-stage Small-cell Lung Cancer
Interventions: DRUG: Association of lurbinectedin and durvalumab|DRUG: Association of carboplatin and etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Standard Versus Flexible Tip Bougie for Videolaryngoscopy
Status: UNKNOWN
Conditions: Intubation, Intratracheal
Interventions: DEVICE: Standard Bougie|DEVICE: Flexi-tip Bougie (P3 Medical Bristol,UK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Carbetocin Versus Oxytocin for Prevention of Postcesarean Hemorrhage in Pregnancy With High Risk for PPH
Status: COMPLETED
Conditions: Postpartum Hemorrhage|Cesarean Section|High Risk Pregnancy
Interventions: DRUG: Carbetocin|DRUG: oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Different Laboratory Management Strategies and Drug Regimens in HIV-infected Children in Africa
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: OTHER: Clinically Driven Monitoring (CDM)|OTHER: Laboratory plus Clinical Monitoring (LCM)|DRUG: Arm A: ABC+3TC+NNRTI|DRUG: Arm B: ZDV+ABC+3TC+NNRTI->ABC+3TC+NNRTI maintenance|DRUG: Arm C: ZDV+ABC+3TC+NNRTI->ZDV+ABC+3TC maintenance|DRUG: Once-daily ABC+3TC|DRUG: Twice-daily ABC+3TC|DRUG: Continued cotrimoxazole prophylaxis|OTHER: Stopped cotrimoxazole prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acetazolamide in Central Sleep Apnea Patients Using Medication for Opioid Use Disorder
Status: NOT_YET_RECRUITING
Conditions: Central Sleep Apnea Comorbid With Opioid Use
Interventions: DRUG: Acetazolamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1b Study of a Cancer Vaccine to Treat Patients With Advanced Stage Ovarian, Fallopian or Peritoneal Cancer
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Cancer
Interventions: BIOLOGICAL: DPX-Survivac|BIOLOGICAL: DPX-Survivac(Aqueous)|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optic Nerve Sheath Diameter in Retrobulbar Ultrasound as a Surrogate Measure for Intracranial Pressure Before and After Non-invasive Strategies
Status: COMPLETED
Conditions: Intracranial Hypertension|Optic Nerve Sheath Diameter
Interventions: DIAGNOSTIC_TEST: optical nerve sheet diameter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Alternating Thalidomide and Lenalidomide Therapy Plus Rituximab (ThRiL) as Initial Treatment for Patients With CLL
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: thalidomide|DRUG: lenalidomide|BIOLOGICAL: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lamictal in the Treatment of Post-Herpetic Neuralgia
Status: TERMINATED
Conditions: Neuralgia, Postherpetic
Interventions: DRUG: Lamictal in the treatment of Post-Herpetic Neuralgia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose:
Clinical trial: Improving eHealth Literacy of Older Adults in Hong Kong
Status: RECRUITING
Conditions: eHealth Literacy
Interventions: BEHAVIORAL: Lecture on eHealth literacy|BEHAVIORAL: Digital intervention on eHealth literacy|BEHAVIORAL: Lecture on general health|BEHAVIORAL: Digital intervention on general health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Diagnosis and Treatment of Undiagnosed Asthma or COPD: THE UCAP 2 TRIAL
Status: RECRUITING
Conditions: COPD|Asthma
Interventions: OTHER: Early diagnosis and treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Prospective Randomized Controlled Trial of Mobile Medical Used for Management of Pregnant Women
Status: COMPLETED
Conditions: Maternal Behavior|Mobile Health|Pregnancy Outcome|GDM|Blood Glucose|Diet Habit|Compliance, Patient
Interventions: BEHAVIORAL: telemedicine: management through WeChat group chat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Macular Edema Incidence/Severity Reduction With Nevanac
Status: TERMINATED
Conditions: Diabetic Retinopathy
Interventions: DRUG: Nepafenac ophthalmic suspension, 0.1% (NEVANAC®)|DRUG: Nepafenac ophthalmic suspension vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Metformin on Gut Peptides , Bile Acids and Lipid Profiles in Type 2 Diabetics
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Sensory Attributes of Selenium-fortified Biscuits and Their Effects on Selenium-status
Status: COMPLETED
Conditions: Selenium Status
Interventions: DIETARY_SUPPLEMENT: Selenium-fortified biscuits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: MeT4VeT: Mental Health Toolkit for Military Veterans Trial
Status: COMPLETED
Conditions: Mental Health Issue|Mental Health Wellness 1
Interventions: BEHAVIORAL: MeT4VeT mobile phone app: control|BEHAVIORAL: MeT4VeT mobile phone app: intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bifidobacteria In Children With Abdominal Pain-Associated Functional Gastrointestinal Disorders
Status: COMPLETED
Conditions: Irritable Bowel Syndrome|Dyspepsia Chronic
Interventions: DRUG: Mixture of three Bifidobacteria
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Therapy in Limb Girdle Muscular Dystrophy
Status: WITHDRAWN
Conditions: Limb Girdle Muscular Dystrophy
Interventions: BIOLOGICAL: Autologous bone marrow mononuclear cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between Oral Liposomal Iron,Iron Supported Lactoferrin and IV Iron Dextran in CKD Children
Status: NOT_YET_RECRUITING
Conditions: CKD - Chronic Kidney Disease
Interventions: DRUG: Ferric Pyrophosphate Liposomal|DRUG: Lactoferrin|DRUG: Iron Dextran Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Immunogenicity of Two Different Formulations of an Influenza A Vaccine (FP-01.1)
Status: COMPLETED
Conditions: Influenza A
Interventions: BIOLOGICAL: FP-01.1|BIOLOGICAL: FP-01.1-Adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Cognitive Outcome After Surgical and Transcatheter Aortic Valve Replacement
Status: COMPLETED
Conditions: Postoperative Delirium|Postoperative Cognitive Dysfunction|Transcatheter Aortic Valve Replacement|Surgical Aortic Valve Replacement
Interventions: PROCEDURE: Transcatheter Aortic Valve Implantation|PROCEDURE: Surgical Aortic Valve Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PK and Bioavailability Comparison of Tofacitinib Between a Modified Release and The Immediate Release Formulation
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: tofacitinib MR 11 mg|DRUG: tofacitinib IR 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Disease-Specific Questionnaire in Assessing Quality of Life in Patients With Gastrointestinal-Related Neuroendocrine Tumors
Status: UNKNOWN
Conditions: Gastrointestinal Carcinoid Tumor|Islet Cell Tumor|Lung Cancer|Metastatic Cancer|Neoplastic Syndrome
Interventions: OTHER: questionnaire administration|PROCEDURE: quality-of-life assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of IMU-131 (HER-Vaxx) in Combination With Chemotherapy or Pembrolizumab in Patients With Metastatic HER2/Neu Over-Expressing Gastric Cancer (nextHERIZON)
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Cancer|Cancer of Stomach|Gastric Adenocarcinoma|Stomach Cancer|Stomach Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma
Interventions: BIOLOGICAL: IMU-131|DRUG: Ramucirumab plus Paclitaxel|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Non-invasive Vestibular System Masking for Improving Outcomes Following Acute Unilateral Vestibulopathy
Status: SUSPENDED
Conditions: Dizziness|Nausea
Interventions: DEVICE: Otoband|DEVICE: Placebo Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Swimming Adapted, Therapeutic Exercise and Health Education in the Treatment of Chronic Neck Pain
Status: COMPLETED
Conditions: Chronic Neck Pain
Interventions: OTHER: Multimodal Physiotherapy Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rapid Atrial Pacing After TAVI to Predict Pacemaker Implantation
Status: RECRUITING
Conditions: Aortic Valve Disease|Transcatheter Aortic Valve Implantation|TAVI
Interventions: DIAGNOSTIC_TEST: Rapid atrial pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Hypercapnia Treatment on Respiratory Recovery After Spinal Cord Injury
Status: RECRUITING
Conditions: Sleep Apnea|SCI/D|Hypercapnia
Interventions: OTHER: Hypercapnia treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study to Compare the Effect of Two PrEP-001 Nasal Powder Formulations on Nasal Mucosa and Serum Cytokine Production
Status: COMPLETED
Conditions: Upper Respiratory Tract Infections
Interventions: DRUG: PrEP-001 6.4 mg|DRUG: PrEP-001 6.4 mg|DRUG: PrEP-001 3.2 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Economic Evaluation of Vancomycin Therapeutic Drug Monitoring Methods
Status: COMPLETED
Conditions: Infection, Bacterial
Interventions: DRUG: Vancomycin-traditional dosing|DRUG: Vancomycin- Trough-only based dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Combination of GX-188E Vaccination and Pembrolizumab in Patients With HPV 16 and/or 18+ Advanced Cervical Cancer
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: DRUG: GX-188E|DRUG: KEYTRUDA®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Study to Assess Long-term Safety of Repeat Administration of Botulinum Toxin Type A for Moderate to Severe Crow's Feet Lines
Status: TERMINATED
Conditions: Skin Aging
Interventions: DRUG: Botulinum Toxin Type A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acetic Acid Chromoendoscopy to Judge Gastric Intestinal Metaplasia
Status: COMPLETED
Conditions: Stomach Neoplasms|Metaplasia
Interventions: PROCEDURE: Acetic acid chromoendoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study To Assess The Safety, Tolerability And Pharmacokinetics Of PF-06282999 Administered Orally In Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06282999|DRUG: Placebo|DRUG: PF-06282999|DRUG: Placebo|DRUG: PF-06282999|DRUG: Placebo|DRUG: PF-06282999|DRUG: Placebo|DRUG: PF-06282999|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Outcomes of Vitrectomy Combined With Subtenon Triamcinolone Injection for the Idiopathic Epiretinal Membrane
Status: UNKNOWN
Conditions: Epiretinal Membrane
Interventions: PROCEDURE: Vitrectomy only group|PROCEDURE: Combined therapy group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Antiviral Effect, and Pharmacokinetics of Celgosivir in Combination With Peginterferon Alfa-2b and Ribavirin in Treatment-Naïve Patients With Chronic Hepatitis C
Status: UNKNOWN
Conditions: Chronic Hepatitis C
Interventions: DRUG: Celgosivir|DRUG: Celgosivir|DRUG: Peginterferon alfa 2b + ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II/III Study of Continuous Local Anesthetic Infusion in Median Sternotomy Following Cardiac Surgery
Status: TERMINATED
Conditions: Cardiac Surgery
Interventions: DRUG: Ropivacaine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT