pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Botulinum Toxin Type A Injection After Topical Anesthesia Versus Petrolatum Ointment
Status: COMPLETED
Conditions: Forehead Rhytides|Forehead Wrinkles
Interventions: DRUG: Botulinum toxin type A|DRUG: 2.5% lidocaine/2.5% prilocaine|DEVICE: petrolatum ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Treatment of Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplasia
Status: COMPLETED
Conditions: Leukemia, Myelocytic, Acute
Interventions: DRUG: Cladribine, Cyclophosphamide, Cytarabine, Daunorubicin, Dexamethasone|DRUG: Etoposide, Cytarabine, Gemtuzumab, L-asparaginase, Mercaptopurine, methotrexate, Mitoxantrone, Prednisone, Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Omega 3 on Oxidative Stress and Nutritional Status of Children on Regular Dialysis
Status: RECRUITING
Conditions: Oxidative Stress
Interventions: DIETARY_SUPPLEMENT: D3 LAB SYRUP|DIETARY_SUPPLEMENT: placebo syrup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Palbociclib, Letrozole & Venetoclax in ER and BCL-2 Positive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Neoplasm Female
Interventions: DRUG: Venetoclax|DRUG: Palbociclib|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Response to SLT vs. ALT in Patients Under 60 Years of Age
Status: COMPLETED
Conditions: Glaucoma
Interventions: PROCEDURE: Argon laser trabeculoplasty|PROCEDURE: Selective laser trabeculoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Home-based, Self-administered Exercise Program for Hands in Patients With Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis|Scleroderma|Hand Rheumatism|Rehabilitation
Interventions: OTHER: Home-based Hand exercise|OTHER: Care advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy and Safety of a New Formulation of Insulin Glargine With Lantus in Patients With Type 2 Diabetes Insufficiently Controlled With Non-insulin Antidiabetic Therapy
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Insulin glargine (U300)|DRUG: Insulin glargine|DRUG: Non-insulin antihyperglycemic drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Study Designed to Evaluate the Safety and Preliminary Efficacy of ApoCell for the Prevention of Acute GvHD
Status: UNKNOWN
Conditions: Graft Versus Host Disease|Hematological Malignancies
Interventions: BIOLOGICAL: ApoCell
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Depression Screening in Patients Undergoing Radiation Therapy For Cancer
Status: COMPLETED
Conditions: Depression|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BEHAVIORAL: telephone-based intervention|OTHER: screening questionnaire administration|OTHER: study of socioeconomic and demographic variables|PROCEDURE: assessment of therapy complications|PROCEDURE: psychosocial assessment and care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Seasonal Influenza Vaccine, Quadrivalent Versus Trivalent in Patients With Advanced Chronic Obstructive Pulmonary Disease
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: BIOLOGICAL: Fluzone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study to Evaluate Safety, Tolerability and Pharmacokinetics/-Dynamics of AK1967 (Procizumab)
Status: RECRUITING
Conditions: Safety and Tolerability
Interventions: DRUG: AK1967 (Procizumab)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: In Vivo Assessment of Hypoxia in Gastro-intestinal Cancer Using 18F-HX4-PET: an Optimization and Reproducibility Study
Status: COMPLETED
Conditions: Pancreatic Cancer|Esophageal Cancer|Rectal Cancer
Interventions: DRUG: [F-18]HX4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Multisensoral Nature-based Intervention in Hospitalized Children During Venous Blood Sampling
Status: NOT_YET_RECRUITING
Conditions: Anxiety|Fear|Pain|Satisfaction
Interventions: OTHER: Multisensoral Nature-based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Versus Intermittent Bolus Infusion of Paravertebral Blocks for Thoracic Surgery
Status: COMPLETED
Conditions: Thoracic Diseases
Interventions: OTHER: Programmed Intermittent Bolus|OTHER: Continuous Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Mesh Reinforcement During Temporary Stoma Closure After Sphincter-Saving Rectal Cancer Surgery
Status: COMPLETED
Conditions: Incisional Hernia After Diverting Stoma Closure
Interventions: DEVICE: Biologic Mesh|DEVICE: Synthetic Mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prescription Opioid Effects in Abusers Versus Non-Abusers
Status: COMPLETED
Conditions: Opioid-Related Disorders|Substance-Related Disorders
Interventions: DRUG: oxycodone 15 mg|DRUG: oxycodone 30 mg|DRUG: Placebo 0 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of Cardiac Output in Patients With ARDS Implanted With Venous-venous ECMO.
Status: RECRUITING
Conditions: Acute Respiratory Distress Syndrome
Interventions: DEVICE: Transpulmonary thermodilution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Contribution of Near-InfraRed Spectroscopy (NIRS) to the Evaluation of Healing After Amputation of the Leg
Status: TERMINATED
Conditions: A Stabilized Definitive Prosthesis (Procedure 1)|Definitive Prosthesis With a Contact Socket (Procedure 1)|Patients in the Initial Phase (Temporary Prosthesis, Rehabilitation) Following Unilateral Post- Transtibial Amputation (Procedure 2)
Interventions: DEVICE: Measurements using NIRS|DEVICE: TCPO2 measurements|OTHER: 2-minute walk test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacodynamics and Pharmacokinetics Study of Existing DMPA Contraceptive Methods
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: DMPA 150|DRUG: DMPA 300|DRUG: DMPA 104
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study on TIL for the Treatment of Advanced Melanoma
Status: RECRUITING
Conditions: Advanced Melanoma|Tumor Infiltrating Lymphocyte|Treatment Side Effects|Effects of Immunotherapy
Interventions: BIOLOGICAL: Tumor Infiltrating Lymphocyte
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS)
Status: TERMINATED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: SAR443820|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Flu,Alemtuzumab,and TBI Followed By Donor Stem Cell Chronic Phase CML
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: Campath|DRUG: Fludarabine|RADIATION: Total Body Irradiation (TBI)|OTHER: T-Cell Deplete
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Walking in Patients With Systemic Lupus Erythematosus
Status: UNKNOWN
Conditions: Systemic Lupus Erythematosus
Interventions: BEHAVIORAL: walking|OTHER: Routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Norepinephrine / Vasopressin Combination for Resuscitation in Septic Shock
Status: COMPLETED
Conditions: Septic Shock|Acute Kidney Injury
Interventions: DRUG: norepinephrine / Vasopressin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cocktail Sedation Containing Propofol Versus Conventional Sedation for Endoscopic Retrograde Cholangiopancreatography (ERCP)
Status: COMPLETED
Conditions: Disorders of Gallbladder, Biliary Tract and Pancreas
Interventions: DRUG: propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy Assessment of Intravitreal Injection of Conbercept in Patients With Polypoidal Choroidal Vasculopathy (PCV)
Status: UNKNOWN
Conditions: Polypoidal Choroidal Vasculopathy (PCV)
Interventions: DRUG: Conbercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Bactericidal Activity of Rifampin + Meropenem + Amoxicillin/Clavulanate in Adults With Pulmonary TB
Status: COMPLETED
Conditions: Tuberculosis, Pulmonary
Interventions: DRUG: Rifampin|DRUG: MEROPENEM 2 grams TID|DRUG: MEROPENEM 1 gram TID|DRUG: MEROPENEM 3 grams QD|DRUG: Amoxicillin/Clavulanate Potassium 500 MG-125 MG Oral Tablet|DRUG: Amoxicillin/Clavulanate Potassium 875 MG-125 MG Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gamma Frequency Stimulation in Individuals With Down Syndrome
Status: RECRUITING
Conditions: Down Syndrome
Interventions: DEVICE: GENUS device (Active Settings)|DEVICE: GENUS device (Sham Settings)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Radical Concurrent Chemoradiotherapy With DDP/5-FU and PD-1 Antibody for Non-metastatic Rectal Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Rectal Squamous Cell Carcinoma
Interventions: COMBINATION_PRODUCT: PD-1 and CRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-operative Loop Diuretics to Improve Same-day Discharge Rates After HoLEP
Status: RECRUITING
Conditions: BPH With Urinary Obstruction|BPH|Hematuria|Same Day Discharge
Interventions: DRUG: Furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Application of Sterile Water to the Skin of Extremely Low Birth Weight (ELBW) Infants
Status: COMPLETED
Conditions: Fluid Loss|Dehydration|Extreme Immaturity
Interventions: OTHER: Sterile water application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Plerixafor for Stem Cell Mobilization in Normal Donors
Status: COMPLETED
Conditions: Blood And Marrow Transplantation
Interventions: DRUG: Filgrastim|DRUG: Plerixafor|PROCEDURE: Apheresis Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Relative Bioavailability of and Effect of Food on a New Oral Tablet Formulation of GLPG3970
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG3970 oral solution|DRUG: GLPG3970 tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Mirtazapine for Agitation in Dementia
Status: COMPLETED
Conditions: Dementia
Interventions: DRUG: Mirtazapine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetic Study of Oral Maraviroc and Maraviroc 1% Gel in HIV-1 Seronegative Adults
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: DRUG: Maraviroc 300 mg tablet (PO) and Maraviroc 1% gel (PR and PV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Atorvastatin Versus Ezetimibe and Fenofibrate as a Lipid-lowering Strategy
Status: COMPLETED
Conditions: Dyslipidemia|Vascular Disease
Interventions: DRUG: Lipitor 20 mg|DRUG: Combination Ezetrol 10 mg and Lipidil Supra 160 mg
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A First-in-human Study of SCTB35 in Patients With Relapse/Refractory B-cell Non-Hodgkin Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Non-Hodgkin Lymphoma, B-cell
Interventions: DRUG: SCTB35 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: eArly levoDopa With Opicapone in Parkinson's paTients wIth motOr fluctuatioNs.
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: Opicapone|DRUG: L-DOPA/DDCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Average Volume Assured Pressure Support With Bi-Level Pressure Support Nocturnal Ventilation
Status: COMPLETED
Conditions: Chronic Hypercapnic Respiratory Failure|Obesity Hypoventilation Syndrome|Chronic Obstructive Pulmonary Disease
Interventions: PROCEDURE: Average volume assured pressure support (AVAPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Patritumab Deruxtecan in Patients With Solid Tumor Harboring an NRG1 Fusion
Status: NOT_YET_RECRUITING
Conditions: Solid Tumor, Adult
Interventions: DRUG: Patritumab Deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Left Atrial Distensibility to Predict Left Ventricular Filling Pressure and Prognosis in Patients With Severe Mitral Regurgitation
Status: COMPLETED
Conditions: Mitral Valve Insufficiency|Atrial Fibrillation|Heart Failure
Interventions: PROCEDURE: Cardiac catheterization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Self-administered Acupressure for Depression
Status: RECRUITING
Conditions: Depressive Symptoms|Depressive Disorder|Depression
Interventions: BEHAVIORAL: Self-administered acupressure group|BEHAVIORAL: Mental health education group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Benefit of Prophylactic Anticonvulsant in Post Cardiac Arrest Syndrome With Induced Mild Hypothermia
Status: UNKNOWN
Conditions: Cardiac Arrest
Interventions: DRUG: Use of prophylactic anticonvulsants (valproate, clonazepam)|DRUG: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: IPH4102 Alone or in Combination With Chemotherapy in Patients With Advanced T Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma, T-Cell|Lymphoma, T-Cell, Cutaneous|Mycosis Fungoides/Sezary Syndrome
Interventions: BIOLOGICAL: IPH4102
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Mitochondrial Respiration in the Cardioprotective Capacity of IPC in Diabetic and Non-diabetic Patients
Status: COMPLETED
Conditions: Reperfusion Injuries, Myocardial
Interventions: DRUG: Dimethyl Malonate|BIOLOGICAL: Ischemic preconditioning|OTHER: Ischemia reperfusion|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: High-Dose Combination Chemotherapy Plus Peripheral Stem Cell Transplantation Compared With Standard Combination Chemotherapy in Treating Women With High-Risk Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: CMF regimen|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: epirubicin hydrochloride|DRUG: fluorouracil|DRUG: mesna|DRUG: methotrexate|DRUG: tamoxifen citrate|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: low-LET electron therapy|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of MMFS in Early AD
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DIETARY_SUPPLEMENT: MMFS-205-SR|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Prestoma-Trial for Parastomal Hernia Prevention
Status: TERMINATED
Conditions: Rectal Adenocarcinoma
Interventions: DEVICE: Parietene Macro|DEVICE: Parietex Parastomal|DEVICE: Dynamesh IPST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effects of Photobiomodulation on Endothelial Function in Healthy Subjects
Status: UNKNOWN
Conditions: Healthy Behavior
Interventions: DEVICE: Low level laser therapy - 1|DEVICE: Low level laser therapy - 2|DEVICE: Low level laser therapy - 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1b/2 Study of Carfilzomib in Relapsed Solid Tumors, Multiple Myeloma, or Lymphoma
Status: COMPLETED
Conditions: Ovarian Cancer|Renal Cancer|Non-small Cell Lung Cancer|Small Cell Lung Cancer|Solid Tumors|Multiple Myeloma|Lymphoma
Interventions: DRUG: Carfilzomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calcitonin in the Treatment of Fibromyalgia
Status: WITHDRAWN
Conditions: Fibromyalgia
Interventions: DRUG: salmon calcitonin|DRUG: intranasal saline solution plus glycerol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Telemonitoring and Telemedicine Service for Hypertensive Care
Status: COMPLETED
Conditions: Hypertension
Interventions: PROCEDURE: Telemonitoring|PROCEDURE: Telemonitoring & Telemedicine|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Radiosurgery in Treating Patients With Kidney Tumors
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: RADIATION: stereotactic radiosurgery|PROCEDURE: Renal Biopsy|PROCEDURE: Serum Blood Markers
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Naltrexone Among Polysubstance Users
Status: COMPLETED
Conditions: Methamphetamine|Alcohol
Interventions: DRUG: Intermittent Oral Naltrexone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Study Will Evaluate Average 24-hr Sodium Excretion During Dapagliflozin Treatment in Patients With Type 2 Diabetes Mellitus With Preserved or Impaired Renal Function or Non-diabetics With Impaired Renal Function.
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2|Kidney Function Tests
Interventions: DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of CT-L01 Compared to Co-administration (ALO 25 mg and MET XR 1,000 mg) in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CT-L01|DRUG: Alogliptin Benzoate 25 mg|DRUG: Metformin HCl XR 1,000 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Establishing the Iodine Requirement in Infancy
Status: COMPLETED
Conditions: Focus: Establish the Iodine Requirement During Infancy
Interventions: DIETARY_SUPPLEMENT: Infant formula|OTHER: Breast milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Detection of Preterm Labour by Cervical Length
Status: UNKNOWN
Conditions: Preterm Labour
Interventions: DEVICE: transvaginal ultrasound|DRUG: Progesterone Vaginal Suppository|PROCEDURE: cervical cercalage|OTHER: digital vaginal exam|DEVICE: abdominal ultrasound|DRUG: Tocolytic Agents
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A MAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers and PHN Patients.
Status: RECRUITING
Conditions: Post Herpetic Neuralgia|Pain|Osteoarthritis|Neuropathic Pain|Chronic Pain|Dorsal Root Ganglion|Nav 1.7
Interventions: DRUG: iN1011-N17 HCl Suspension (Part 1)|DRUG: iN1011-N17 HCl Capsule (Part 1)|DRUG: Placebo Capsule (Part 1)|DRUG: iN1011-N17 HCl Capsule (Part 2)|DRUG: iN1011-N17 Mesylate Capsule (Part 2)|DRUG: iN1011-N17 HCl Capsule (Part 3)|DRUG: iN1011-N17 Mesylate Capsule (Part 3)|DRUG: Placebo Capsule (Part 3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Copanlisib in Hepatic or Renal Impairment
Status: COMPLETED
Conditions: Hepatic Insufficiency, Renal Insufficiency
Interventions: DRUG: Copanlisib (ALIQOPA, BAY80-6946)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of 124I-NM404 in Advanced Solid Malignancies
Status: TERMINATED
Conditions: Triple Negative Breast, Prostate, Colorectal, Gastric, Ovarian, Pancreatic, Esophageal, Soft Tissue Sarcoma, and Head & Neck Cancer
Interventions: DRUG: 124I-NM404
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial on Laparoscopic Hysterectomy Versus Robotic Hysterectomy
Status: TERMINATED
Conditions: Hysterectomy
Interventions: PROCEDURE: Robotic hysterectomy|PROCEDURE: Standard Hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ezetimibe/Simvastatin (10 mg/40 mg) vs. the Doubling of Atorvastatin in High Risk Participants (MK-0653A-134 AM1)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: ezetimibe/simvastatin 10/40|DRUG: atorvastatin 40 mg|DRUG: atorvastatin 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl Use
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder
Interventions: DRUG: Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of a Prophylactic Plasmid DNA Vaccine for COVID-19 [Covigenix VAX-001] in Adults
Status: COMPLETED
Conditions: SARS-CoV-2
Interventions: BIOLOGICAL: Covigenix VAX-001 placebo|BIOLOGICAL: Covigenix VAX-001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SCT-I10A or Placebo Plus Docetaxel With Previously Treated Squamous Cell Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Squamous-cell Non-Small-cell Lung Cancer
Interventions: DRUG: SCT-I10|DRUG: Docetaxel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Periimplant Soft Tissue Phenotype on Marginal Bone Loss
Status: COMPLETED
Conditions: Alveolar Bone Loss|Dental Implant|Periimplantitis
Interventions: DIAGNOSTIC_TEST: Nuclear Factor-Kappa B Ligand (RANKL) analysis|DIAGNOSTIC_TEST: Osteoprotegerin (OPG) analysis|DIAGNOSTIC_TEST: Tumor Necrosis Factor Alpha (TNF-α) analysis|DIAGNOSTIC_TEST: MicroRNA-223 analysis|DIAGNOSTIC_TEST: Microrna-27a analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Sweetness on Neurocognitive Responses, Glycemia and Food Intake
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Natural high potency sweetener from leaf extract|DIETARY_SUPPLEMENT: Glucose|DIETARY_SUPPLEMENT: Sucrose|DIETARY_SUPPLEMENT: Maltodextrin|DIETARY_SUPPLEMENT: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia
Status: RECRUITING
Conditions: Dementia|Memory Loss|Alzheimer Disease|Executive Dysfunction|Mobility Limitation
Interventions: DEVICE: Transcranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (active)|DEVICE: Transcranial alternating current stimulation (tACS) (sham); Transcranial direct current stimulation (tDCS) (sham)|DEVICE: Transcranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (sham)|DEVICE: Transcranial alternating current stimulation (tACS) (sham); Transcranial direct current stimulation (tDCS) (active)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MA-0211 in Healthy Adult Subjects Including a Food Effect Cohort
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: MA-0211|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Specific Neck Rehabilitation for Unilateral Headache and Neck Pain, and Structural and Functional Changes in the Brain
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervicogenic Headache
Interventions: BEHAVIORAL: Specific neck rehabilitation|OTHER: Standard primary health care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Therapeutics (DTx) for Pain: Pilot Study of a Virtual Reality Software for Chronic Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: OTHER: DTx for pain software|OTHER: Control software|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Prevention of Preterm Birth Using Cervical Pessary in Pregnant Women After Threatened Preterm Labor(PECEP-RETARD)
Status: COMPLETED
Conditions: Preterm Birth
Interventions: DEVICE: Device: Silicon ring (Arabin Pessary)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acitretin in Preventing Skin Cancer in Patients at High Risk for Skin Cancer
Status: COMPLETED
Conditions: Non-melanomatous Skin Cancer
Interventions: DRUG: acitretin|GENETIC: gene expression analysis|GENETIC: northern blotting|GENETIC: polymerase chain reaction|GENETIC: protein expression analysis|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of ZVS101e in Patients With Bietti 's Crystalline Dystrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: Bietti's Crystalline Dystrophy
Interventions: DRUG: ZVS101e
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Baricitinib for Treating Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotype.
Status: NOT_YET_RECRUITING
Conditions: Hospital-acquired Pneumonia
Interventions: DRUG: Baricitinib 4 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weight-loss Drug for Fertility-Sparing Treatment of Atypical Hyperplasia and Grade 1 Cancer of the Endometrium
Status: NOT_YET_RECRUITING
Conditions: Endometrial Cancer|Atypical Hyperplasia
Interventions: DRUG: Mounjaro|DRUG: Mirena
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smart Kneebrace for Continuous Monitoring of Joint Angles During Rehabilitation
Status: UNKNOWN
Conditions: Arthroplasty, Replacement, Knee|Knee Osteoarthritis
Interventions: DEVICE: Smart Kneebrace with a smart phone app|OTHER: regular rehabilitation procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Travoprost/Timolol vs Latanoprost/Timolol Fixed Combination Therapy
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Travoprost/timolol therapy|DRUG: Latanoprost/Timolol therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Administration of High Dose Thiotepa and Melphalan With Autologous Hematopoietic Stem Cell Transplant in Children and Adolescents With Solid Tumors
Status: UNKNOWN
Conditions: Central Nervous System Tumors|Tumors
Interventions: DRUG: thiotepa melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Projected Peripheral Defocus Using a Wearable Device
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Active projection of defocused image in the peripheral visual field (eSpecs, Acucela Inc.)|DEVICE: No Active projection of defocused image in the peripheral visual field (eSpecs, Acucela Inc.)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study of Group Metacognitive Therapy Versus Mindfulness Meditation Therapy
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: BEHAVIORAL: Group Metacognitive Therapy|BEHAVIORAL: Mindfulness Meditation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Asenapine Using an Active Control in Subjects With Schizophrenia or Schizoaffective Disorder (25517)(P05935)
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: asenapine|DRUG: olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endobronchial Valve for Emphysema Palliation Trial (VENT)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Emphysema
Interventions: PROCEDURE: Emphasys Endobronchial Valve and procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMD-1041 Chronic Obstructive Pulmonary Disease: Proof of Concept (POC) Study
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: IMD-1041|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Testing MK-3475 (Pembrolizumab) After Surgery for Localized Muscle-Invasive Bladder Cancer and Locally Advanced Urothelial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Localized Renal Pelvis and Ureter Urothelial Carcinoma|Locally Advanced Bladder Urothelial Carcinoma|Locally Advanced Renal Pelvis and Ureter Urothelial Carcinoma|Locally Advanced Ureter Urothelial Carcinoma|Locally Advanced Urothelial Carcinoma|Stage II Bladder Urothelial Carcinoma AJCC v6 and v7|Stage II Renal Pelvis and Ureter Cancer AJCC v7|Stage II Ureter Cancer AJCC v7|Stage III Bladder Urothelial Carcinoma AJCC v6 and v7|Stage III Renal Pelvis and Ureter Cancer AJCC v7|Stage III Ureter Cancer AJCC v7
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Clinical Observation|PROCEDURE: Computed Tomography|PROCEDURE: CT Urography|PROCEDURE: Cystoscopy|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Pembrolizumab|OTHER: Pharmacological Study|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thalidomide With or Without Fludarabine in Treating Patients With Hematologic Cancer
Status: TERMINATED
Conditions: Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia
Interventions: DRUG: fludarabine phosphate|DRUG: thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Korea of Entecavir Versus Lamivudine in Adults With Chronic Hepatitis B Infection
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Entecavir|DRUG: Lamivudine Placebo|DRUG: Lamivudine|DRUG: Entecavir Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combining Topical Corticosteroid and LCD Treatment for Localized Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Corticosteroid|OTHER: Placebo|DRUG: LCD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Epidermal Growth Factor Receptor (EGFR) Status Based Gefitinib Neoadjuvant Therapy in Non Small Cell Lung Cancer (NSCLC)
Status: SUSPENDED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Oxycodone to Control Moderate or Severe Oral Mucositis Pain Induced by Chemoradiotherapy
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Controlled-release oxycodone|OTHER: Chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Comorbid Depression and Substance Abuse in Young People
Status: COMPLETED
Conditions: Depression|Substance-Related Disorders
Interventions: DRUG: sertraline|BEHAVIORAL: Cognitive Behavioural Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SWOG-8819 Collecting, Analyzing, and Storing Tissue Samples From Patients With Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: OTHER: biologic sample preservation procedure|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of a Topical Spray on Itch Relief in Moderate-to-severe Childhood Eczema
Status: COMPLETED
Conditions: Eczema
Interventions: DRUG: Atoderm SOS spray Aerosol 200ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carbofix Pedicle Screw System: Evaluation of the Clinical and Radiographic Outcomes of the Use of a Carbon Fiber Device Compared to Titanium Devices in Patients Undergoing Spinal Arthrodesis for Degenerative Spinal Diseases
Status: RECRUITING
Conditions: Degenerative Disc Disease
Interventions: PROCEDURE: Titanium|PROCEDURE: Carbofix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Mini-midline and the Peripheral Intravenous Catheter
Status: COMPLETED
Conditions: Vascular Access Devices|Venous Puncture
Interventions: PROCEDURE: Long Peripheral Catheter|PROCEDURE: Peripheral Intra-Venous Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Bactericidal Activity of Linezolid, Gatifloxacin, Levofloxacin, Isoniazid (INH) and Moxifloxacin in HIV Negative Adults With Initial Episodes of Sputum Smear-Positive Pulmonary Tuberculosis
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: Gatifloxacin|DRUG: Isoniazid|DRUG: Levofloxacin|DRUG: Linezolid|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Ezatiostat (Telintra Tablets) for Treatment of Severe Chronic Neutropenia
Status: TERMINATED
Conditions: Severe Chronic Neutropenia
Interventions: DRUG: Ezatiostat Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Atezolizumab for Patients With Extensive Stage Small Cell Lung Cancer (SCLC) With Untreated, Asymptomatic Brain Metastases
Status: TERMINATED
Conditions: Small-cell Lung Cancer|Brain Metastases
Interventions: DRUG: Carboplatin|DRUG: Etoposide|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib Following Liver Transplantation in Patients of Hepatocellular Carcinoma With Portal Vein Tumor Thrombus
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma|Portal Vein Tumor Thrombus|Liver Transplantation
Interventions: DRUG: lenvatinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Fluzone® Vaccine in Children Who Received 2 Doses of the 2005-2006 Fluzone Formulation.
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza Virus Vaccine, Fluzone®|BIOLOGICAL: Influenza Virus Vaccine, Fluzone®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Loose-dose Combination of Acarbose and Metformin for T2DM in Metformin-failure Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Acarbose|DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Toripalimab Combined With Surufatinib for Locally Advanced Thyroid Cancer: a Phase II Study
Status: UNKNOWN
Conditions: Thyroid Cancer
Interventions: DRUG: Surufatinib|DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Y-3 Injection in the Treatment of Acute Ischemic Stroke Phase II Clinical Trial
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Y-3 Injection/Y-3 blank injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Learning Skills Together Family Caregiver Complex Intervention
Status: RECRUITING
Conditions: Dementia|Alzheimer Disease|Caregiver Burden|Self Efficacy
Interventions: BEHAVIORAL: Learning Skills Together Intervention|BEHAVIORAL: Caregiver Healthy Living Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of LBBAP vs RVP on the Incidence of New-onset Atrial Fibrillation in Patients With Atrioventricular Block
Status: NOT_YET_RECRUITING
Conditions: Left Bundle Branch Area Pacing|Right Ventricular Pacing|Atrioventricular Block|Atrial Fibrillation
Interventions: PROCEDURE: left bundle branch area pacing|PROCEDURE: right ventricular pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DBT-Based Parenting Intervention for Parents of Youth at Risk for Suicide
Status: COMPLETED
Conditions: Adolescent - Emotional Problem|Suicide and Self-harm|Parenting
Interventions: BEHAVIORAL: DBT-Based Parenting Intervention|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Patient Decision-Making Aids for Patients With Unilateral Ureteral Stone: A Randomized-Controlled Trial
Status: UNKNOWN
Conditions: Patient Decision Aids|Ureteral Stone|Shared Decision Making
Interventions: OTHER: Decision aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Atorvastatin on Blood Pressure and Urinary Albumin Excretion
Status: COMPLETED
Conditions: Hypertension|Hypercholesterolemia
Interventions: DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare and Measure the Effects of Insulin Peglispro (LY2605541) and Glargine on Meal Time Insulin Requirements
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Insulin Peglispro|DRUG: Insulin Lispro|DRUG: Insulin Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Personalized Immunotherapeutic for Antibiotic-resistant Infection
Status: COMPLETED
Conditions: Infection|Immune Deficiency|Hypogammaglobulinemia|Septic Arthritis|Mycoplasma Hominis
Interventions: BIOLOGICAL: anti-mycoplasma hominis antibodies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regional TAP Block for Bariatric Patients
Status: COMPLETED
Conditions: Bariatric Surgery|Transverse Abdominal Plane Regional Blocks
Interventions: PROCEDURE: Transverse abdominal plane block|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Calcium Silicate-based Sealer and Epoxy Resin-based Sealer
Status: COMPLETED
Conditions: Pulpitis - Irreversible|Pain, Postoperative
Interventions: DRUG: Epoxy resin-based sealers (ERS)|DRUG: Calcium silicate-based sealers (CSS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of Laquinimod in Participants With Systemic Lupus Erythematosus (SLE) Active Lupus Arthritis
Status: COMPLETED
Conditions: Lupus Arthritis
Interventions: DRUG: Laquinimod|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Concomitant Administration of Cilostazol and Probucol on Biomarkers, Endothelial Function and Safety
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: DRUG: Cilostazol, Probucol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT