pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Umbilical Cord Blood-Derived Natural Killer Cells, Elotuzumab, Lenalidomide, and High Dose Melphalan, Followed by Stem Cell Transplant in Treating Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Plasma Cell Leukemia|Plasma Cell Myeloma
Interventions: PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation|BIOLOGICAL: Elotuzumab|OTHER: Laboratory Biomarker Analysis|DRUG: Lenalidomide|DRUG: Melphalan|BIOLOGICAL: Natural Killer Cell Therapy|BIOLOGICAL: Umbilical Cord Blood-Derived Lymphocyte Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy of Vitamin D and Vitamin D-calcium Fortified Yogurt Drink in Diabetic Patients
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: plain yogurt drink|DIETARY_SUPPLEMENT: vitamin D fortified yogurt drink|DIETARY_SUPPLEMENT: vitamin D-calcium yogurt drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Effects of Exendin(9-39) on Gastroduodenal Motility
Status: COMPLETED
Conditions: Digestive Physiology|Gastrointestinal Motility|Gastrointestinal Hormones|Glucagon-like Peptide 1|Exendin (9-39)
Interventions: DRUG: exendin(9-39)amide|DRUG: atropine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Associations of Exposure to Bisphenol A With Blood Pressure and Epigenetic Change
Status: COMPLETED
Conditions: Hypertension
Interventions: OTHER: Can 1|OTHER: Can 2|OTHER: Glass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Determine Safety, Pharmacokinetics and Efficacy of GMI-1271 in Combination With Chemotherapy in AML
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: GMI-1271|DRUG: Mitoxantrone|DRUG: Etoposide|DRUG: Cytarabine|DRUG: Idarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interleukin-2 Plus Histamine Dihydrochloride in Treating Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: aldesleukin|DRUG: histamine dihydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of Gemcitabine and ON 01910.Na in Solid Tumors
Status: COMPLETED
Conditions: Malignant Neoplasmas|Solid Tumors
Interventions: DRUG: gemcitabine|DRUG: ON 01910.Na
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Efficacy Study Evaluating the Combination of Bevasiranib & Lucentis Therapy in Wet AMD (CARBON)
Status: WITHDRAWN
Conditions: Age Related Macular Degeneration
Interventions: DRUG: Bevasiranib|DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-extractive Inter-radicular Implant Bed Preparation Versus Conventional Post-extractive Inter-radicular Implant Bed Preparation in Mandibular Molars
Status: UNKNOWN
Conditions: Randomized Clinical Trial
Interventions: PROCEDURE: Post-extractive inter-radicular implant bed preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of DFD01 Spray Versus Comp01 Lotion, Vehicle Spray and Vehicle Lotion in Subjects With Moderate Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: DFD01 Spray|DRUG: Comp01 Lotion|DRUG: Vehicle Lotion|DRUG: Vehicle Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerance of "on Line" Hemodiafiltration in Chronic Renal Failure Patients
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: PROCEDURE: On line Hemodiafiltration|PROCEDURE: Hemodialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Icotinib Hydrochloride Cream in Healthy Adults and Psoriasis Patients
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: 1% icotinib hydrochloride cream|DRUG: 2% icotinib hydrochloride cream|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy and Safety With CAR-T for Recurrent or Refractory Acute Non T Lymphocyte Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia
Interventions: BIOLOGICAL: CD19-targeted CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-blind (db), Placebo-controlled 18 Week Study of Linagliptin (BI 1356) in Type 2 Diabetic Patients With Insufficient Glycaemic Control on a Sulfonylurea Drug
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: BI 1356|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Mobile Technology and Data Analytics to Identify Real-time Predictors of Caregiver Well-Being
Status: COMPLETED
Conditions: Caregivers
Interventions: BEHAVIORAL: Just-in-time adaptive intervention (JITAI)|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Multinational Study of Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis|Interstitial Lung Disease
Interventions: DRUG: Placebo|DRUG: Inhaled Treprostinil|DEVICE: Treprostinil Ultrasonic Nebulizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Immunogenicity Study of Sm-p80 + GLA-SE (SchistoShield(R)) Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Schistosomiasis
Interventions: BIOLOGICAL: Sm-p80|BIOLOGICAL: Sm-p80 + GLA-SE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: GLP-1 Analogs for Neuroprotection After Cardiac Arrest
Status: COMPLETED
Conditions: Cardiac Arrest|Coma
Interventions: DRUG: Byetta (Lilly, Exenatide)|OTHER: 20% Human Albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Shockwave Therapy vs Mesotherapy in the Treatment of Myofascial Pain Syndrome: a Case-control Study
Status: COMPLETED
Conditions: Myofascial Pain Syndrome|Trigger Point Pain, Myofascial
Interventions: OTHER: Extracorporeal Shockwave Therapy (Group A)|OTHER: Mesotherapy (Group B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-Stress Intervention Among Physicians Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Stress, Psychological|Burnout, Psychological|Subjective Stress|Occupational Stress
Interventions: BEHAVIORAL: Box Breathing|BEHAVIORAL: Breathing and Mindfulness Exercise|BEHAVIORAL: Everyday life control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monoclonal Antibody Therapy in Treating Patients With Ovarian Epithelial Cancer, Melanoma, Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative|Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Myeloid Leukemia|Recurrent Melanoma|Recurrent Non-small Cell Lung Cancer|Recurrent Ovarian Epithelial Cancer|Stage IV Melanoma|Stage IV Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-dose Buprenorphine as a Modulator of Social Motivation in Schizophrenia
Status: NOT_YET_RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: Placebo|DRUG: Buprenorphine 0.15 MG [Belbuca]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Exploring Efficacy of Peginterferon in Patients With Herpes Zoster
Status: COMPLETED
Conditions: Herpes Zoster
Interventions: DRUG: Peginterferon α1b|DRUG: Peginterferon α1b with valacyclovir|DRUG: Valacyclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Parent Education and Medical Play: A Comparison of Psychological Preparation Strategies for Voiding Cystourethrogram
Status: TERMINATED
Conditions: Vesicoureteral Reflux
Interventions: BEHAVIORAL: Parental information|BEHAVIORAL: Play therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PEG-Interferon a-2b + Ribavirin for Treatment of Chronic HRN 005 Hepatitis C Infection in HIV-Infected Persons Not Previously Treated With Interferon
Status: COMPLETED
Conditions: Chronic Hepatitis C Infection in HIV-Infected Persons|HIV Infections
Interventions: DRUG: PEG-Interferon a-2b + Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose-Ranging Study With Vupanorsen (TRANSLATE-TIMI 70)
Status: COMPLETED
Conditions: Dyslipidemias|Hyperlipidemias|Hyperlipoproteinemias
Interventions: DRUG: Vupanorsen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Focused Spinal Stenosis Rehabilitation Program for Lumbar Spinal Stenosis
Status: WITHDRAWN
Conditions: Spinal Stenosis Lumbar
Interventions: PROCEDURE: Williams flexion protocol|PROCEDURE: Focused spinal stenosis rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pitch Perception and Memory: Deficits and Training
Status: RECRUITING
Conditions: Cochlear Implants
Interventions: BEHAVIORAL: Listening tests. Pitch training protocol|BEHAVIORAL: visuo-spatial training protocol|BEHAVIORAL: EEG/MEG/MRI recordings.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Belimumab in Idiopathic Inflammatory Myositis
Status: COMPLETED
Conditions: Myositis
Interventions: DRUG: Belimumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Verapamil vs Heparin in Transradial Procedures
Status: COMPLETED
Conditions: Heart Disease, Ischemic
Interventions: DRUG: Heparin|DRUG: Verapamil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fruquintinib and Serplulimab Combination Therapy for First-line Treatment of Non-clear Cell Renal Cell Carcinoma: A Prospective Multicenter Study
Status: NOT_YET_RECRUITING
Conditions: First-line Treatment of Non-clear Renal Cell Carcinoma
Interventions: DRUG: Fruquintinib combined with Serplulimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: recombinant CD40-ligand|BIOLOGICAL: therapeutic autologous dendritic cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kabat Technique and Neuromuscular Effect in Patients With Bell's Palsy
Status: COMPLETED
Conditions: Bell Palsy
Interventions: OTHER: Kabat Technique's|OTHER: Neuromuscular Re-Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study of Idelalisib in Participants With Chronic Lymphocytic Leukemia (CLL) Who Participated in GS-US-312-0116 (NCT01539512)
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Idelalisib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ultrasonic Activation of Bioceramic Sealer on Postoperative Pain in Lower Premolars
Status: COMPLETED
Conditions: Symptomatic Irreversible Pulpitis
Interventions: OTHER: ultrasonic activation of bioceramic sealer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a 10 Component Dietary Supplement on Health and the Quality of Life
Status: COMPLETED
Conditions: Blood Pressure|HDL Low|Stress|Lung Function Decreased|Quality of Life|Energy Supply; Deficiency|Concentration Ability Impaired|Joint Instability|Immune Deficiency
Interventions: DIETARY_SUPPLEMENT: Stem Cell 100+
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of the Quadruple Immunosuppression on Peripheral Blood Lymphocytes and Development of Anti-HLA Antibodies in Kidney Transplant
Status: UNKNOWN
Conditions: Kidney Transplantation
Interventions: DRUG: Sirolimus|DRUG: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Impact of the PVP With Greenlight Laser Using Prostatic MRI and Contrast-enhanced Ultrasound
Status: COMPLETED
Conditions: Prostatic Hypertrophy, Benign
Interventions: DEVICE: prostatic photo-vaporization (PVP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Tesofensine/Metoprolol Treatment in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Tesofensine/Metoprolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Efficacy of BFH772 in Rosacea Patients
Status: COMPLETED
Conditions: Erythemato-telangiectatic Rosacea
Interventions: DRUG: BFH772 1% ointment|DRUG: Vehicle ointment|DRUG: Noritate® 1% cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remineralization Effect of Eggshell Powder on Post-orthodontic White Spot Lesions Compared to CPP-ACP
Status: UNKNOWN
Conditions: Dental Caries
Interventions: OTHER: Eggshell powder gel|OTHER: CPP-ACP crème
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-dose Dexamethasone Plus Hetrombopag vs High-dose Dexamethasone Alone as Frontline Treatment for Newly Diagnosed Adult Primary Immune Thrombocytopenia: A Prospective, Multicenter, Randomized Trial
Status: RECRUITING
Conditions: ITP - Immune Thrombocytopenia
Interventions: DRUG: hetrombopag 5mg po qd|DRUG: High-dose Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Pharmacokinetic (PK) and Pharmacodynamic(PD) of Biocon Insulin 70/30 and Humulin® 70/30
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: BIOLOGICAL: Humulin ®70/30|BIOLOGICAL: Biocon Insulin 70/30
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: pBFS Guided High-dose rTMS Therapy for Treatment-Resistant Depression
Status: RECRUITING
Conditions: Treatment-Resistant Depression
Interventions: DEVICE: Active rTMS with short inter-session interval|DEVICE: Sham rTMS with short inter-session interval|DEVICE: Active rTMS with long inter-session interval
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FIH Study With CBSO
Status: COMPLETED
Conditions: Atrial Septal Defect (ASD)|Patent Foramen Ovale (PFO)
Interventions: DEVICE: Device Closure of Atrial Septal Defect
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Irrigation Solutions on Postoperative Pain and Lesion Healing
Status: RECRUITING
Conditions: Endodontic Disease
Interventions: OTHER: Using ethylenediaminetetraacetic acid (EDTA), citric acid ((MONO/ANH) and etidronic acid (HEBP) to clean root canals during regenerative endodontic treatments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Observation of Propofol Titration at Different Speeds
Status: COMPLETED
Conditions: Anesthesia, General|Hemodynamics
Interventions: DRUG: 2mg/kg/min|DRUG: 1mg/kg/min|DRUG: 0.5mg/kg/min
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peroperative Assessment of Tumour Resection Margins Using High-resolution 18F-FDG-PET/CT in Pancreatic Adenocarcinoma
Status: TERMINATED
Conditions: Fluorodeoxyglucose F18
Interventions: DIAGNOSTIC_TEST: Positron Emissie Tomografie - Computer Tomografie
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy, Safety and Tolerability of Telbivudine in HBeAg Positive Chronic Hepatitis B Pregnant Women With Elevated Alanine Aminotransferase Levels
Status: COMPLETED
Conditions: Chronic Hepatitis B|Pregnancy Complications|High Viral Load|Elevated Alanine Aminotransferase Levels
Interventions: DRUG: Telbivudine treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of BI 1467335 Tablet and Oral Solution, and Food Effect on Tablet in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: BI 1467335 (Treatment A)|DRUG: BI 1467335 (Treatment B)|DRUG: BI 1467335 (Treatment C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Yoga Counselling on Quality of Life and Psychological Outcomes of Prostate Cancer Patients
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BEHAVIORAL: Counselling based on yoga|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Comparing LEO 80190 Ointment With Hydrocortisone Ointment, Both Applied Once Daily in the Treatment of Psoriasis Vulgaris on the Face and Intertriginous Areas
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: LEO 80190|DRUG: Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients Who Have Undergone a Donor Stem Cell Transplant and Have Cytomegalovirus Infection That Has Not Responded to Therapy
Status: COMPLETED
Conditions: Cancer
Interventions: BIOLOGICAL: cytomegalovirus pp65-specific cytotoxic T lymphocytes|GENETIC: polymerase chain reaction|OTHER: diagnostic laboratory biomarker analysis|OTHER: flow cytometry|OTHER: immunologic technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Th1, Th2 and Monokine Responses as Risk Factors of Renal Transplant Rejection
Status: COMPLETED
Conditions: Renal Failure, Chronic
Interventions: PROCEDURE: Kidney transplantation|DRUG: cyclosporine A|DRUG: tacrolimus|DRUG: azathioprine|DRUG: mycophenolate mofetil
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart Failure
Status: ENROLLING_BY_INVITATION
Conditions: Systolic Heart Failure
Interventions: DRUG: Eplerenone|DRUG: Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic Supplementation in Severe Depression
Status: COMPLETED
Conditions: Severe Depression
Interventions: DIETARY_SUPPLEMENT: Vivomixx®|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy With E7 T Cell Receptor T Cells for Vulvar High-Grade Squamous Intraepithelial Lesions
Status: TERMINATED
Conditions: Squamous Lntraepithelial Lesions of Vulva|Neoplasms, Squamous Cell|Vulvar HSIL
Interventions: BIOLOGICAL: E7 T Cell Receptor (TCR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Non-invasive Positive Pressure Ventilation on Cardiac Function and Echocardiographic Parameters
Status: COMPLETED
Conditions: Heart Function Tests|Hemodynamics|Noninvasive Ventilation|Circulatory and Respiratory Physiological Phenomena
Interventions: OTHER: Non-invasive positive pressure ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Bupivacaine Liposomal vs Bupivacaine Combined With Dexamethasone for Postoperative Pain in VATS
Status: RECRUITING
Conditions: Thoracic Surgery
Interventions: PROCEDURE: Rhombic intercostal nerve block(Received liposomal bupivacaine 93 mg and bupivacaine 25 mg diluted to 20 ml)|PROCEDURE: Rhombic intercostal nerve block(Receive standard bupivacaine 105 mg diluted to 20 ml with dexamethasone 5 mg.)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine Safety, Feasibility and Efficacy of JCAR015 in Adult Subjects With B-Cell Acute Lymphoblastic Leukemia
Status: WITHDRAWN
Conditions: Precursor Cell Lymphoblastic Leukemia-Lymphoma
Interventions: DRUG: JCAR015
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study Comparing Tamoxifen vs. Tamoxifen + Aminoglutethimide in Postmenopausal Receptor-positive Patients
Status: COMPLETED
Conditions: Early-stage Breast Cancer
Interventions: DRUG: Tamoxifen alone|DRUG: Tamoxifen + Aminoglutethimide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Gulf War Illness
Status: RECRUITING
Conditions: Gulf War Illness|Irritable Bowel Syndrome|Gastrointestinal Symptoms
Interventions: DIETARY_SUPPLEMENT: Oral Glutamine|OTHER: Control Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness
Status: RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Advanced Microsatellite Stable Colorectal Carcinoma|Hematopoietic and Lymphatic System Neoplasm|Metastatic Malignant Solid Neoplasm|Metastatic Microsatellite Stable Colorectal Carcinoma|Stage III Colorectal Cancer AJCC v8|Stage IV Colorectal Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Temozolomide|DRUG: Tuvusertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen for Carbon Monoxide Induced Chronic Encephalopathy
Status: WITHDRAWN
Conditions: Carbon Monoxide Poisoning|Chronic Encephalopathy
Interventions: DEVICE: hyperbaric oxygen and sham hyperbaric oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Docetaxel and Ramucirumab Versus Docetaxel and Placebo in the Treatment of Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer Metastatic
Interventions: DRUG: Ramucirumab|DRUG: Placebo|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of PCI-32765 (Ibrutinib) in Patients With Refractory Follicular Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: PCI-32765 (Ibrutinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: National Screening in Denmark With MR Versus Mammography and Ultrasound of Women With BRCA1 or BRCA2 Mutations
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: PROCEDURE: MR mammography|PROCEDURE: MR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Open Label Trial Assessing Safety and Efficacy of Burosumab (KRN23), in a Patient With ENS and Hypophosphatemic Rickets
Status: COMPLETED
Conditions: Hypophosphatemia|Hypophosphatemic Rickets|Pain, Chronic
Interventions: BIOLOGICAL: Burosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Costoclavicular vs Paracoracoid Approach to Infraclavicular Brachial Plexus Block: a Feasibility Study
Status: COMPLETED
Conditions: Upper Limb Injury
Interventions: DRUG: Ropivacaine|DEVICE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Human Milk Oligosaccharide (HMO) Supplementation in Colic Management
Status: TERMINATED
Conditions: Colic
Interventions: DIETARY_SUPPLEMENT: HMO|DIETARY_SUPPLEMENT: Placebo|BEHAVIORAL: Parental reassurance and support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Assessment of Early Pancreatic Cancer Prognosis by Minimal Residual Disease Using Multi-omics Approach
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma
Interventions: OTHER: Blood collection and Pancreatic ductal adenocarcinoma minimal residual disease detection test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cognitive Functional Therapy Compared With Sham-treatment for Low Back Pain
Status: UNKNOWN
Conditions: Chronic Low-back Pain
Interventions: BEHAVIORAL: Cognitive Functional Therapy (CFT)|DEVICE: Sham intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy of Prolotherapy Injection Therapy & Local Anesthetic Injection Therapy.
Status: COMPLETED
Conditions: Myofascial Pain Syndrome of Neck
Interventions: DRUG: Dextrose solution|DRUG: Lidocain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Thawing Embryos in Advance and on the Day of Transfer on Pregnancy Outcomes in FET Cycle
Status: UNKNOWN
Conditions: In Vitro Fertilization|Frozen Embryo Transfer
Interventions: PROCEDURE: Thawing Embryos in Advance|PROCEDURE: Thawing Embryos on the Day of Transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: TVEC and Preop Radiation for Sarcoma (4 ml Dose)
Status: COMPLETED
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: Talimogene Laherparepvec|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compound Sodium Alginate Double Action Chewable Tablet Symptomatic Relief Study
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease|Dyspepsia
Interventions: DRUG: Compound Sodium Alginate Double Action Chewable Tablets|DRUG: Matching placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of JS001 Combined With Chemotherapy in Patients With Locally Advanced Colon Cancer
Status: RECRUITING
Conditions: Colonic Neoplasms|Chemotherapy Effect
Interventions: DRUG: Anti-PD-1 Monoclonal Antibody JS001|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Connectivity Affecting the Antidepressant REsponse Study
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Escitalopram|DRUG: Bupropion XL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Pure Epicatechin and Cocoa on Markers of Vascular Function
Status: COMPLETED
Conditions: Endothelial Dysfunction|Bioavailability
Interventions: DIETARY_SUPPLEMENT: Pure Epicatechin|DIETARY_SUPPLEMENT: High flavan-3-ol cocoa|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Topical rVA576 for Treatment of Atopic Keratoconjunctivitis
Status: TERMINATED
Conditions: Atopic Keratoconjunctivitis (AKC)
Interventions: DRUG: rVA576|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Lirentelimab (AK002) in Patients With Active Eosinophilic Duodenitis
Status: COMPLETED
Conditions: Eosinophilic Duodenitis|Eosinophilic Gastroenteritis
Interventions: DRUG: AK002|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mü-opioid Receptor Level and Postoperative Pain in Patients With Gynecological Laparoscopy
Status: COMPLETED
Conditions: Gynecological; Surgery (Previous), Affecting Fetus|Postoperative Pain
Interventions: OTHER: follicular cyclus|OTHER: luteal cyclus
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of Disability Compensation With the C-LEG COMPACT 2 Knee (Ref. 3C60 et 3C60=ST)
Status: COMPLETED
Conditions: Amputation of Hip and Thigh, Level Unspecified
Interventions: DEVICE: 3C60-NMPK|DEVICE: NMPK-3C60
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Feasibility of the First Known Adaptive Intervention for People With SCI
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: BEHAVIORAL: Movement-2-Music + Social Networking Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: HomeStyles-2: Shaping HOME Environments and LifeSTYLES to Prevent Childhood Obesity
Status: RECRUITING
Conditions: Healthy Lifestyle|Home Environment Related Disease|Cognitive Change|Child Behavior|Child Obesity|Parenting|Parents|Parent-Child Relations
Interventions: BEHAVIORAL: HomeStyles-2: Obesity Prevention Program for Families with Children in Middle Childhood
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Differently Fed Farmed Gilthead Sea Bream Consumption
Status: COMPLETED
Conditions: Cardiometabolic Health
Interventions: BEHAVIORAL: Conventional fish|BEHAVIORAL: Enriched fish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Atorvastatin 40 mg in Patients With Relapsing-Remitting Multiple Sclerosis Treated With Interferon-Beta-1b
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Interferon beta 1b|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Glycaemic Benefits of Active Versus Passive Lifestyle Intervention in Kidney Allograft Recipients
Status: COMPLETED
Conditions: Post Transplantation Diabetes Mellitus|Obesity|Transplantation of Kidney
Interventions: BEHAVIORAL: Active lifestyle intervention|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: SMS Education for Post-operative Pain
Status: COMPLETED
Conditions: Opioid Use|Pain, Postoperative
Interventions: BEHAVIORAL: SMS education|BEHAVIORAL: SMS survey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VTP-1000 in Adults With Celiac Disease
Status: RECRUITING
Conditions: Celiac Disease
Interventions: BIOLOGICAL: VTP-1000|OTHER: Matched Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety and Efficacy of Human BCMA Targeted CAR-NK Cells Injection for Subjects With R/R MM or PCL
Status: RECRUITING
Conditions: Multiple Myeloma|Plasma Cell Leukemia
Interventions: DRUG: Human BCMA targeted CAR-NK cells injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanical Ventilation, Directed by Esophageal Pressure Measurements, in Patients With Acute Lung Injury
Status: COMPLETED
Conditions: Acute Lung Injury|Acute Respiratory Distress Syndrome
Interventions: PROCEDURE: Placement of an esophageal balloon measurements|OTHER: Low tidal volume ventilation|OTHER: Transpulmonary pressure-directed ventilation (EPVent)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phenotypes, Biomarkers and Pathophysiology in Spastic Ataxias
Status: RECRUITING
Conditions: Spastic Ataxia
Interventions: OTHER: Clinical rating scale to measure Ataxia disease severity and progression|OTHER: Clinical rating scale to measure spastic paraplegia disease severity and progression|OTHER: Disease-specific severity index for adults with autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)|DIAGNOSTIC_TEST: Next-Gen Sequencing (NGS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Corticotrophin-releasing Hormone (CRH) Stimulation for 18F-FDG-PET Detection of Pituitary Adenoma in Cushing s Disease
Status: NOT_YET_RECRUITING
Conditions: Cushing's Disease|Pituitary Adenoma
Interventions: DRUG: Acthrel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Individually Tailored Web-based Multimodal Pain Rehabilitation in Primary Health Care
Status: COMPLETED
Conditions: Musculoskeletal Pain
Interventions: BEHAVIORAL: Web-based multimodal rehabilitation based on cognitive based principles
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Home-based Delivery of the Contraceptive Implant in Postpartum Guatemalan Women
Status: COMPLETED
Conditions: Postpartum
Interventions: OTHER: Offer of Participant's Choice of Contraception Method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of GRC 54276 in Participants With Advanced Solid Tumors and Lymphomas.
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumor|Lymphoma
Interventions: DRUG: GRC 54276|DRUG: GRC 54276 + Pembrolizumab|DRUG: GRC 54276 + Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Paired Testing to Poorly Controlled Chinese Diabetes on Glycemic Control and Self Care
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Diabetes Mellitus, Type 1
Interventions: DEVICE: Paired testing of blood glucose Accu-Chek®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety Dermatological Evaluation: Acceptability With Gynecological Follow up - Dermacyd Breeze
Status: COMPLETED
Conditions: Hygiene
Interventions: DRUG: Lactic acid (Dermacid)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pilot Study of Nocturnal Hypoglycemia Prevention in Type 1 Diabetes Using the Vigilant Diabetes Management Companion
Status: TERMINATED
Conditions: Hypoglycemia|Diabetes Mellitus, Type 1
Interventions: DEVICE: Vigilant Diabetes Management Application
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prednisone Treatment for Vestibular Neuronitis
Status: COMPLETED
Conditions: Vestibular Diseases|Vestibular Neuronitis
Interventions: DRUG: Prednisone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quality of Recovery of Remimazolam Versus Sevoflurane in Transurethral Bladder Resection.
Status: COMPLETED
Conditions: Quality of Recovery
Interventions: DRUG: Sevoflurane|DRUG: Remimazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Placebo-controlled Trial of Transdiscal Radiofrequency Annuloplasty
Status: COMPLETED
Conditions: Lower Back Pain
Interventions: DEVICE: The Transdiscal Radiofrequency Annuloplasty|DEVICE: The Transdiscal Radiofrequency Annuloplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nasal Poly-ICLC (Hiltonol®) in Healthy COVID-19 Vaccinated Adults
Status: COMPLETED
Conditions: COVID - 19
Interventions: DRUG: Poly-ICLC (Hiltonol®) or Placebo|DRUG: Poly-ICLC (Hiltonol®) or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Relationship of Intra-Epidermal Nerve Fibre Density (IENFD) and Structure to Chronic Post-Mastectomy Pain Syndrome (PMPS)
Status: COMPLETED
Conditions: Chronic Pain|Pain Measurement|Mastectomy|Postoperative Pain
Interventions: OTHER: Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Pupillometry-guided Anesthesia With Surgical Pleth Index Guided Anesthesia
Status: COMPLETED
Conditions: Cholecystectomy, Laparoscopic|Anesthesia, General|Reflex, Pupillary
Interventions: PROCEDURE: Pupillometry guided anesthesia|PROCEDURE: SPI guided anesthesia|PROCEDURE: Standard management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: The Effect of Xolair (Omalizumab) on Allergy Blood Cells
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Omalizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of AMG 910 in Subjects With CLDN18.2-Positive Gastric and Gastroesophageal Junction Adenocarcinoma
Status: TERMINATED
Conditions: Gastric and Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: AMG 910
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hexvix Photodynamic Therapy in Patients With Bladder Cancer
Status: COMPLETED
Conditions: Intermediate or High-risk Bladder Cancer
Interventions: OTHER: Hexvix PDT with Karl Storz T-Light
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxycodone (10, 20 mg) in a Postoperative Dressing
Status: COMPLETED
Conditions: Burns
Interventions: DRUG: Oxycodone 10mg|DRUG: Oxycodone 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multinational Study to Evaluate the Effects of a 28-Day Oral Contraceptive on Hemostatic Parameters in Healthy Women
Status: COMPLETED
Conditions: Hemostasis|Oral Contraceptive
Interventions: DRUG: desogestrel/ethinyl estradiol and ethinyl estradiol|DRUG: desogestrel/ethinyl estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of an Alarm Management Protocol on Noise Pollution and Patient Safety in Intensive Care Units
Status: RECRUITING
Conditions: Intensive Care Unit
Interventions: DEVICE: alarm management left to the discretion of the nurse|DEVICE: restrictive alarm use strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison Between Volatile Anesthetic-desflurane and Total Intravenous Anesthesia With Propofol and Remifentanil on Early Recovery Quality and Long Term Prognosis of Patients Undergoing Pancreatic Cancer and Common Bile Duct Cancer Surgery
Status: UNKNOWN
Conditions: Pancreatic Cancer or Distal CBD Cancer
Interventions: DRUG: Des (volatile anesthetic-desflurane)|DRUG: TIVA (Total intravenous anesthesia with propofol and remifentanil)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Safety and Efficacy Study of SAR405838 and Pimasertib in Cancer Patients
Status: COMPLETED
Conditions: Neoplasm Malignant
Interventions: DRUG: SAR405838|DRUG: Pimasertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Long-term Study of TAK-536TCH in Participants With Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: TAK-536TCH tablet|DRUG: TAK-536CCB tablet|DRUG: HCTZ 12.5 mg tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Degenerative Spondylolisthesis; Micro-decompression vs Decompression + Instrumented Fusion; Long Term Follow up
Status: ACTIVE_NOT_RECRUITING
Conditions: Degenerative Lumbar Spondylolisthesis
Interventions: PROCEDURE: Surgical treatment of Degenerative Spondylolisthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Levosimendan as Treatment of Aneurysmal SubArachnoid Haemorrhage
Status: RECRUITING
Conditions: Sub-arachnoid Haemorrhage
Interventions: DRUG: Levosimendan|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT