pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Diagnostic Utility of Different Airway Resistance Assessment Techniques in the Methacholine Challenge Test
Status: COMPLETED
Conditions: Bronchial Hyperreactivity|Abnormal Respiratory Airway Resistance
Interventions: OTHER: Methacholine Challenge Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Observational Follow-up Study to Evaluate Duration of Treatment Effect of Pentosan Polysulfate Sodium in Participants With Knee Osteoarthritis Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Pentosan Polysulphate Sodium|DRUG: Placebo (Sodium Chloride Injection, 0.9%)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of a Diabetes Self-management Coaching Program for Type 2 Diabetes Patients in the Ethiopian PC.
Status: COMPLETED
Conditions: Type 2 Diabetes|Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Diabetes self-management Coaching|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of Fixation Strategies for Severe Open Tibia Fractures
Status: COMPLETED
Conditions: Severe Open Fractures of the Tibia (Shin) Bone
Interventions: PROCEDURE: Surgery with an external ring fixator|PROCEDURE: Definitive fixation with a locked IM nail or plate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Taxotere/Prednisone Plus Sunitinib in Chemotherapy-Naïve, Hormone Refractory Prostate Cancer Patients
Status: TERMINATED
Conditions: Prostate Cancer|Adenocarcinoma of the Prostate|Recurrent Prostate Cancer|Stage I Prostate Cancer|Stage III Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: sunitinib malate|DRUG: docetaxel|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simultaneous Gemcitabine and Irreversible Electroporation for Locally Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: PROCEDURE: simultaneous gemcitabine and irreversible electroporation|PROCEDURE: irreversible electroporation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Prospective Observational Study to Evaluate the Incidence of Delayed-onset Nodules of YVOIRE Y-Solution 360, YVOIRE Y-Solution 540 or YVOIRE Y-Solution 720 Injected Into the Facial Skin Layer.
Status: COMPLETED
Conditions: Healthy Condition
Interventions: DIAGNOSTIC_TEST: Medical examination or treatment.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Therapeutic Time Window of Mannitol During Craniotomy for Optimal Brain Relaxation in Patients With Supratentorial Tumours
Status: COMPLETED
Conditions: Supratentorial Tumors
Interventions: DRUG: Mannitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Carboplatin and Etoposide With or Without Thalidomide in Treating Patients With Limited-Stage or Extensive-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Carboplatin, etoposide & thalidomide|DRUG: Carboplatin, etoposide & placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Antiemetic Efficacy of Palonosetron Versus Ondansetron for the Prophylaxis of Postoperative Nausea and Vomiting (PONV) in Women Over 60 Years Undergoing Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Ondansetron|DRUG: Palonosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Nanofat on Wound Healing and Scar Formation
Status: UNKNOWN
Conditions: Scars|Delayed Wound Healing|Hypertrophic Scar|Post Inflammatory Hyperpigmentation|Donor Site Complication
Interventions: PROCEDURE: Nanofat injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Effectiveness of Oral Apremilast (CC-10004) in Patients With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Apremilast|DRUG: Placebo|DRUG: Topical treatments or phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Repeat Dose Study in Healthy Volunteers Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK356278
Status: COMPLETED
Conditions: Huntington Disease
Interventions: DRUG: GSK356278|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Medicaid Incentives for the Prevention of Chronic Diseases: Diabetes Prevention
Status: COMPLETED
Conditions: Diabetes Prevention
Interventions: BEHAVIORAL: Process incentives|BEHAVIORAL: Outcome incentives|BEHAVIORAL: Process and Outcome incentives
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rotor Modulation Ablation for the Treatment of Persistent Atrial Fibrillation
Status: NOT_YET_RECRUITING
Conditions: Persistent Atrial Fibrillation
Interventions: PROCEDURE: Electrical Posterior Box Isolation and Rotor Modulation Ablation group (R&B group)|PROCEDURE: Electrical Posterior Box Isolation group (BO group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Blood Glucose Control Using African Traditional Fermented Foods
Status: RECRUITING
Conditions: PreDiabetes
Interventions: DIETARY_SUPPLEMENT: Fermented milk product|DIETARY_SUPPLEMENT: Fermented cereal based product|BEHAVIORAL: Behavioural modification counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Sedative Medications in Patients With Severe Infection and Respiratory Failure
Status: COMPLETED
Conditions: Sepsis|Respiratory Failure|Agitation
Interventions: DRUG: Propofol|DRUG: Dexmedetomidine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Beetroot Juice Supplements on Lower-limb Strength in Females
Status: COMPLETED
Conditions: Muscular Endurance
Interventions: DIETARY_SUPPLEMENT: Beetroot juice|OTHER: Capri-Sun
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Efficacy and Safety of Oxabact (OC5) in Primary Hyperoxaluria Patients Who Are on Dialysis
Status: COMPLETED
Conditions: Primary Hyperoxaluria
Interventions: BIOLOGICAL: Oxalobacter formigenes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Full Thickness vs. Rectal Suction Biopsy in the Diagnosis of Hirschsprungs Disease
Status: UNKNOWN
Conditions: Hirschsprung Disease
Interventions: PROCEDURE: Rectal suction biopsy.|PROCEDURE: Full-thickness rectal biopsy.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Comparative Effectiveness Study Evaluating the Effects of Thermogenic Supplements on Body Composition
Status: COMPLETED
Conditions: Weight Loss
Interventions: DIETARY_SUPPLEMENT: Advantra Z|DIETARY_SUPPLEMENT: Advantra Z + Naringin + Hesperiden|OTHER: Sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Phase 1b Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of JNJ-64565111 in Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: JNJ-64565111|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study, Safety and Efficacy, Ahmed Glaucoma Drainage Device, Model M4 Model S2 in Neovascular Glaucoma
Status: TERMINATED
Conditions: Neovascular Glaucoma
Interventions: PROCEDURE: Surgical Implant of Ahmed Glaucoma Drainage Device, model M4 and S2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Dual-mode Stimulation Therapy for Neurorehabilitation in Post-stroke Cognitive Impairment
Status: COMPLETED
Conditions: Post-stroke Cognitive Impairment
Interventions: DEVICE: High-frequency rTMS on left DLPFC+anodal tDCS on right DLPFC|DEVICE: High-frequency rTMS on left DLPFC+cathodal tDCS on right DLPFC|DEVICE: High-frequency rTMS on left DLPFC+sham tDCS on right DLPFC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cannabidiol for the Treatment of Anxiety Disorders: An 8-Week Pilot Study
Status: RECRUITING
Conditions: Generalized Anxiety Disorder|Social Anxiety Disorder|Panic Disorder|Agoraphobia
Interventions: DRUG: Cannabidiol (CBD) Oil Capsules|DRUG: Sunflower Lecithin Oil in Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metformin Combined With Gemcitabine as Adjuvant Therapy for Pancreatic Cancer After Curative Resection
Status: COMPLETED
Conditions: Stage IA Pancreatic Adenocarcinoma|Stage IB Pancreatic Adenocarcinoma|Stage IIA Pancreatic Adenocarcinoma|Stage IIB Pancreatic Adenocarcinoma
Interventions: DRUG: Gemcitabine|DRUG: Metformin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Increased Liver Stiffness: A Study of Acoustic Radiation Force Impulse (ARFI) Elastography
Status: COMPLETED
Conditions: Liver Fibroses
Interventions: DEVICE: Ultrasound with ARFI (acoustic radiation force impulse)|DEVICE: Ultrasound with backscatter imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the Pan-DAC Inhibitor AR-42 and Pazopanib in Advanced Sarcoma and Kidney Cancer
Status: TERMINATED
Conditions: Renal Cell Carcinoma|Soft Tissue Sarcoma|Metastatic Disease
Interventions: DRUG: AR-42|DRUG: Pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Techniques for Epiretinal or Internal Limiting Membrane Peel
Status: UNKNOWN
Conditions: Epiretinal Membrane|Vitreomacular Traction
Interventions: PROCEDURE: using ILM forceps alone|PROCEDURE: Breaking and peeling with end-grasping forceps
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Combination Chemotherapy Followed By Peripheral Stem Cell Transplantation or Isotretinoin in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Acute Lymphocytic Leukemia
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Myelodysplastic Syndromes|Thrombocytopenia
Interventions: BIOLOGICAL: filgrastim|DIETARY_SUPPLEMENT: vitamin E|DRUG: busulfan|DRUG: cytarabine|DRUG: etoposide|DRUG: fludarabine phosphate|DRUG: isotretinoin|DRUG: topotecan hydrochloride|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Post-Surgical Injection With Triamcinolone Versus Triamcinolone/Fluorouracil in Treatment of Keloids
Status: COMPLETED
Conditions: Keloid|Keloid Scar Following Surgery
Interventions: DRUG: Triamcinolone Injection|DRUG: Triamcinolone Injection and 5-fluorouracil injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Enhancement of Pressure Healing With Pulsatile Lavage
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: PROCEDURE: Pulsatile Lavage|OTHER: sham pulsatile lavage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase II Study With Low-dose Recombinant Human IL-2 for the Treatment of Primary Sjögren's Syndrome
Status: COMPLETED
Conditions: Primary Sjögren's Syndrome
Interventions: DRUG: hrIL-2 active|DRUG: hrIL-2 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hereditary Paraganglioma: Evaluation of Screening Methods to Detect Tumors in SDH Positive Carriers
Status: COMPLETED
Conditions: Paraganglioma|Pheochromocytoma
Interventions: PROCEDURE: diagnosis methods
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase II Multicenter Study of Durvalumab and Olaparib in Platinum tReated Advanced Triple Negative Breast Cancer (DORA)
Status: COMPLETED
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Olaparib Oral Product|DRUG: Olaparib Oral Product in combination with Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Anlotinib and AK105 Injection in Subjects With Advanced Head, Neck and Chest Cancer
Status: UNKNOWN
Conditions: Advanced Head, Neck and Chest Cancer
Interventions: DRUG: AK105|DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FG-4592 for Treatment of Anemia in Subjects With Chronic Kidney Disease Not on Dialysis
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: FG-4592|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Precision and Accuracy of INR Measurements in a Point of Care Device (OPTIMAL)
Status: COMPLETED
Conditions: Deep Vein Thrombosis|Atrial Fibrillation|Post-Myocardial Infarction Syndrome|Pulmonary Embolism|Artificial Heart Device User|Thrombophilia|Antiphospholipid Syndrome
Interventions: PROCEDURE: VKA Patients|PROCEDURE: Non-VKA Patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Examine the Effect of Tesofensine and Metoprolol on the 24-hour Mean Heart Rate
Status: COMPLETED
Conditions: Phase 1
Interventions: DRUG: Metoprolol Succinate 25 MG|DRUG: Metoprolol Succinate 50 MG|DRUG: Metoprolol Succinate 100 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pemetrexed Plus Doxorubicin Given to Patients With Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Pemetrexed|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy of Bare Performance Nutrition's Peak Sleep Supplementation on Sleep Quality and Duration.
Status: COMPLETED
Conditions: Sleep
Interventions: DIETARY_SUPPLEMENT: Bare performance supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Influence of Bariatric Surgery on Serum Levels of 26RFa
Status: UNKNOWN
Conditions: Diabetes|Obesity
Interventions: BEHAVIORAL: Meal test taking and hormones measure including 26RFa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Role of Octreotide in Non Variceal Bleeding
Status: RECRUITING
Conditions: Non-variceal Gastrointestinal Bleeding
Interventions: DRUG: PPI group|DRUG: PPI plus octreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Glucose in Serratus Anterior Plane Block to Reduce the Occurrence of Chronic Post-mastectomy Pain
Status: NOT_YET_RECRUITING
Conditions: Post-mastectomy Pain Syndrome
Interventions: PROCEDURE: unilateral USG-deep SAPB with glucose|PROCEDURE: unilateral USG-deep SAPB without glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cross Body vs Sleeper Stretch on Pain, Range of Motion and Functional Performance in Cricket Bowlers.
Status: RECRUITING
Conditions: Pain|Range of Motion|Physical Functional Performance
Interventions: OTHER: Sleeper Stretch|OTHER: Cross Body Stretch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Cancer|Hematologic Malignancies|Multiple Myeloma|Oncology|Bone Metastases|Multiple Myeloma Bone Lesions
Interventions: DRUG: Denosumab|DRUG: Zoledronic acid|DRUG: Placebo to Denosumab|DRUG: Placebo to zoledronic acid|DRUG: Denosumab (for the open-label treatment phase)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Managed Access Program Cohort Treatment Plan CTMT212X2002I to Provide Access to Trametinib and Dabrafenib Combination Therapy for Patients With BRAF V600 Mutation-positive Advanced Non-Small Cell Lung Cancer
Status: AVAILABLE
Conditions: Small Cell Lung Carcinoma
Interventions: DRUG: Dabrafenib|DRUG: Trametininb
Study Type: EXPANDED_ACCESS
Clinical trial: A Trial Investigating the Influence of Oral Semaglutide on Pharmacokinetics of Ethinylestradiol and Levonorgestrel in an Oral Contraceptive Combination Drug in Healthy Postmenopausal Females
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: semaglutide|DRUG: SNAC|DRUG: Microgynon®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heat and Acupuncture Randomised Controlled Trial to Manage Osteoarthritis of the Knee
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Acupuncture with Heat Therapy + Standard Care|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-Level Laser Therapy (LLLT) Treatment for Breast-Feeding Women With Painful Nipple Lesions
Status: RECRUITING
Conditions: Nipple Lesions
Interventions: DEVICE: Low-Level Laser Therapy|DEVICE: Placebo Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness App Versus Mindfulness-based Intervention for Healthcare Students
Status: COMPLETED
Conditions: Students
Interventions: BEHAVIORAL: REM Volver a casa|BEHAVIORAL: Mindfulness-Based Stress Reduction program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gait Analysis and Clinical Outcomes of Anterior and Lateral Approach Total Hip Arthroplasty.
Status: COMPLETED
Conditions: Hip Osteoarthritis
Interventions: PROCEDURE: total hip replacement using lateral approach|PROCEDURE: total hip replacement using anterior approach|DEVICE: gait analysis at 6wks, 3 months and 18 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lumbar Transforaminal Epidural Corticosteroid Injection(s) Versus Defined Physical Therapy
Status: TERMINATED
Conditions: Lumbar Radiculopathy
Interventions: OTHER: Lumbar Transforaminal Epidural Corticosteroid Injection|OTHER: Physical Therapy|OTHER: Observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary Sarcoidosis
Status: UNKNOWN
Conditions: Pulmonary Sarcoidosis
Interventions: DRUG: Methionine|DRUG: DOTANOC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Validation of a Novel Thoracic Neoplasm Radiotherapy Image Guidance Technique: A Pilot Study
Status: WITHDRAWN
Conditions: Lung Cancer
Interventions: PROCEDURE: reproduce breathing cycle utilizing spirometry|PROCEDURE: Freebreathing in Body fix mold
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: TechCare: Mobile-AssessmenT and ThErapy for PsyCHosis: An Intervention for Clients Within the EArly InteRvention SErvice
Status: UNKNOWN
Conditions: Feasibility Studies
Interventions: OTHER: TechCare
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Outcomes and Efficacy of Ejaculatory Preserving Transurethral Resection of Prostate
Status: NOT_YET_RECRUITING
Conditions: Ejaculatory Dysfunction|BPH
Interventions: PROCEDURE: Ejaculatory Preserving Transurethral resection of prostate|PROCEDURE: Standard Transurethral Resection of prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia Nervosa
Status: COMPLETED
Conditions: Anorexia Nervosa|Major Depressive Disorder|Generalized Anxiety Disorder|Panic Disorder|Brain Injury
Interventions: DRUG: Isoproterenol|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influenza A/H5N1 Vaccine Clinical Trial (IVACFLU-A/H5N1) - Phase 1
Status: COMPLETED
Conditions: Influenza A Subtype H5N1 Infection
Interventions: BIOLOGICAL: IVACFLU-A/H5N1, 7.5 mcg|BIOLOGICAL: IVACFLU-A/H5N1, 15 mcg|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Restoration of the Gut Microbiome After Cesarean Section
Status: NOT_YET_RECRUITING
Conditions: Microbial Colonization
Interventions: BIOLOGICAL: Microbiome restoration - FMT|BIOLOGICAL: Microbiome restoration - FVT|BIOLOGICAL: Placebo|OTHER: Vaginal birth, untreated control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Development of 3D Multi-Parametric Ultrasound (MPUS) as a Decision Support Tool for Patients
Status: RECRUITING
Conditions: Liver Cancer, Adult
Interventions: DIAGNOSTIC_TEST: 3D-MPUS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neuromuscular Electrical Stimulation (NMES) Preserves Muscle Mass in Intensive Care Unit (ICU)
Status: COMPLETED
Conditions: Critical Illness|Physical Disability|Muscle Atrophy
Interventions: OTHER: Patients received the standard physical therapy (SPT) programme (passive mobilization) twice a day.|OTHER: Patients received the low-frequency neuromuscular electrical stimulation (NMES)|OTHER: Patients received the medium-frequency neuromuscular electrical stimulation (NMES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TSA vs RSA in Glenohumeral Osteoarthritis
Status: RECRUITING
Conditions: Osteoarthritis of the Shoulder
Interventions: PROCEDURE: Total Shoulder Arthroplasty|PROCEDURE: Reverse Shoulder Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Virtual Warrior Renew Therapy for Veterans Who Experienced Military Sexual Trauma
Status: RECRUITING
Conditions: Military Sexual Trauma (MST)|Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: Health & Wellness|BEHAVIORAL: Warrior Renew
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Wearable Technology and a Virtual Lifestyle Program for Type 2 Diabetics
Status: COMPLETED
Conditions: Type 2 Diabetes|Comorbidities and Coexisting Conditions
Interventions: BEHAVIORAL: Wearable Activity Trackers, Exercise Prescription and Virtual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase 1 Study to Evaluate MEDI4736 in Subjects With Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Myelodysplastic Syndrome
Interventions: BIOLOGICAL: MEDI4736 Evaluate MEDI4736 in MDS|DRUG: VIDAZA|BIOLOGICAL: tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapy for Hepatitis C Virus (HCV) in Primary Treatment Failure in Pakistan
Status: ENROLLING_BY_INVITATION
Conditions: Hepatitis C
Interventions: DRUG: Epclusa (nucleotide HCV NS5B polymerase inhibitors).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Compare the Immunogenicity, Safety, and Tolerability of an Adjuvanted A(H1N1) Influenza Vaccine Versus Non-Adjuvanted A(H1N1) Influenza Vaccines in Patients With Invasive Solid Tumors
Status: COMPLETED
Conditions: H1N1 Influenza Virus|Invasive Solid Tumors
Interventions: BIOLOGICAL: adjuvanted A(H1N1) influenza vaccine|BIOLOGICAL: non-adjuvanted A(H1N1) influenza vaccine|BIOLOGICAL: non-adjuvanted A(H1N1) influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Prospective Randomized Comparison of Fentanyl, Methadone and Morphine for Epidural Analgesia in an Experimental Pain Model
Status: WITHDRAWN
Conditions: Pain
Interventions: DRUG: Epidural administration of bolus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Baricitinib in Hospitalized Covid-19 Patients With Diabetes Mellitus
Status: WITHDRAWN
Conditions: COVID-19 Pneumonia
Interventions: DRUG: Baricitinib|DRUG: Dexamethasone|DRUG: Remdesivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Dry Needling for Improving Gait in the Patient With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DEVICE: dry needling + physiotherapy (standard/usual care)|OTHER: sham dry needling + physiotherapy (standard/usual care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multisystem Features of Malignant Hyperthermia or Rhabdomyolysis Related to RYR1 Variants
Status: UNKNOWN
Conditions: Malignant Hyperthermia|Rhabdomyolysis|RYR1 Variant
Interventions: OTHER: Immunological challenge
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Safety and Efficacy of the VDyne Transcatheter Tricuspid Valve Replacement System for the Treatment of Tricuspid Regurgitation
Status: RECRUITING
Conditions: Tricuspid Regurgitation|Tricuspid Valve Disease|Tricuspid Valvular Disorders
Interventions: DEVICE: VDyne Transcatheter Tricuspid Valve Replacement System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of the Inhibition of Agouti-related Protein (AgRP) for the Management of Obesity and Weight Loss
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: TTP435|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Online Cognitive Behavior Therapy for Comorbid Sleep Problems in Alcohol Use Disorder
Status: UNKNOWN
Conditions: Alcohol Use Disorder|Insomnia|Sleep Disorder|Dyssomnias
Interventions: BEHAVIORAL: Cognitive behavior therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cementless New Alumina-zirconia Ceramic Bearing Total Hip Arthroplasty (THA) in Asian Patients
Status: UNKNOWN
Conditions: Arthroplasty, Replacement, Hip
Interventions: DEVICE: 4th generation ceramic bearing composite ceramic bearing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Steroid Injection With Percutaneous Needle Aponeurotomy in Dupuytren's Contracture
Status: COMPLETED
Conditions: Dupuytren's Contracture
Interventions: DRUG: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tunlametinib Plus Vemurafenib in Patients With BRAF V600E-mutant Metastatic Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer Metastatic
Interventions: DRUG: Tunlametinib plus Vemurafenib|DRUG: Doublets Chemotherapy ± Bevacizumab or Doublets Chemotherapy ± Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeting Inflammation in Acute Coronary Syndrome Using Colchicine
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Colchicine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DUTCH CAVA-trial: CAtheter Versus Anticoagulation Alone for Acute Primary (Ilio)Femoral DVT.
Status: COMPLETED
Conditions: Acute Thrombosis of Deep Veins of Proximal Lower Extremity
Interventions: DEVICE: Ekos endowave system thrombolysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Tislelizumab Combined With Nab-Paclitaxel for Muscle-invasive Urothelial Bladder Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Muscle Invasive Bladder Cancer|Urothelial Carcinoma
Interventions: DRUG: Tislelizumab|DRUG: Nab paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STACCATO: Stent sTrut Apposition and Coverage in Coronary ArTeries: an Optical Coherence Tomography (OCT) Study
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Xience V everolimus eluting stent|DEVICE: Biolimus A9-eluting Biomatrix stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transrectal and 3D Transabdominal Ultrasound Compared to Vaginoscopy in Diagnosing Virgins With Genital Lesions
Status: COMPLETED
Conditions: Virginity|Genital Diseases, Female|Diagnoses Disease
Interventions: DIAGNOSTIC_TEST: 3D transabdominal ultrasound|DIAGNOSTIC_TEST: transrectal ultrasound|DIAGNOSTIC_TEST: vaginoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Activation Innate Immune System in Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Cardiovascular Diseases|Innate Immune System|Inflammation|Metabolism Disorder, Glucose
Interventions: RADIATION: PET-CT (positron emission tomography - computer tomography)|DIAGNOSTIC_TEST: Blood drawn
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Safety and Efficiency of 20w 30w Holmium Laser Device in Treatment of 1-2 cm Diameter Kidney Stones With RIRS
Status: UNKNOWN
Conditions: Nephrolithiasis
Interventions: PROCEDURE: Retrograde Intrarenal Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Optimal Planning of a Day 3 Cryopreserved(Frozen)-Thawed Embryo Transfer in a Natural Cycle With hCG Administration or After Spontaneous LH Peak?
Status: COMPLETED
Conditions: Supervision of Pregnancy Resulting From In-vitro Fertilization
Interventions: DRUG: hCG|OTHER: LH peak
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: Bioabsorbable Staple Line Reinforcement in Colorectal,Coloanal and Ileoanal Anastomoses
Status: TERMINATED
Conditions: Rectal Cancer|Ulcerative Colitis|Familial Adenomatous Polyposis|Diverticulitis
Interventions: DEVICE: GORE SEAMGUARD® Bioabsorbable Staple Line Reinforcement|PROCEDURE: Staple line without reinforcement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [18F]ISO-1 Positron Emission Tomography (PET/CT) in Primary Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Breast Neoplasm
Interventions: DRUG: [18F]ISO-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Creatine and Rehabilitation Programin Athletes With Patellar Tendinopathy
Status: COMPLETED
Conditions: Creatine|Patellar Tendinopathy
Interventions: DIETARY_SUPPLEMENT: Creatine supplementation|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cystic Fibrosis in the Kidney: Monitoring the Effectiveness of Elexacaftor/Tezacaftor/Ivacaftor in Urine After a Short Pause of Therapy
Status: RECRUITING
Conditions: Cystic Fibrosis (CF)|CFTR Gene Mutation
Interventions: OTHER: 12 hours ETI pause|OTHER: 36 hours ETI pause|OTHER: 60 hours ETI pause
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety Study of Vicagrel in Patients With Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)
Status: NOT_YET_RECRUITING
Conditions: Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)
Interventions: DRUG: Vicagrel|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Avelumab In Patients With Previously Treated Advanced Stage Classical Hodgkin's Lymphoma (JAVELIN HODGKINS)
Status: TERMINATED
Conditions: Hodgkins Lymphoma
Interventions: DRUG: Avelumab|DRUG: Avelumab|DRUG: Avelumab|DRUG: Avelumab|DRUG: Avelumab|DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Time Dependent Professional Toothbrushing Study
Status: COMPLETED
Conditions: Toothbrushing
Interventions: DEVICE: Sonicare elite medium brush head|DEVICE: Sonicare elite mini brushhead|DEVICE: GABA Elmex sensitive extra soft toothbrush|DEVICE: ADA reference toothbrush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stress and CKD Among African Americans
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: BEHAVIORAL: Racialized Stressful Event Recall|BEHAVIORAL: Non-Racialized Stressful Event Recall
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Optimal Dose of Omeprazole After Endoscopic Treatment of Bleeding Peptic Ulcers
Status: COMPLETED
Conditions: Bleeding Peptic Ulcers Disease
Interventions: DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Multikine in the Treatment of Perianal Warts
Status: TERMINATED
Conditions: Condyloma
Interventions: DRUG: Leukocyte Interleukin, Injection 200IU|DRUG: Leukocyte Interleukin, injection 400IU
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Ablative Radiotherapy (SABR) of Pelvis and Prostate Targets For High Risk Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: Stereotactic Ablative Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Analysis on Physical Activity Performance and Motor Function of Affected Upper Extremity Before and After a CIMT Program in Young Children With Hemiparetic Cerebral Palsy
Status: UNKNOWN
Conditions: Hemiplegic Cerebral Palsy With Spasticity (Diagnosis)
Interventions: OTHER: Constraint Induced Movement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomised Placebo-controlled Duloxetine-referenced Efficacy and Safety Study of 2.5, 5 and 10 mg of Vortioxetine (Lu AA21004) in Acute Treatment of Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Placebo|DRUG: Vortioxetine (Lu AA21004)|DRUG: Vortioxetine (Lu AA21004)|DRUG: Vortioxetine (Lu AA21004)|DRUG: Duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Rosacea-related Inflammatory Biochemical Markers in Adult Skin When Treated With Oracea® vs Placebo
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: Doxycycline|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Fluzone® Influenza Virus Vaccine 2011-2012 Formulation (Intramuscular Route) Among Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza Virus Vaccine: Fluzone® 2011-2012 Formulation|BIOLOGICAL: Influenza Virus Vaccine: Fluzone® High-Dose 2011-2012 Formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Operative and Nonoperative Treatment of Humeral Shaft Fractures
Status: UNKNOWN
Conditions: Humeral Diaphyseal Fracture
Interventions: PROCEDURE: Open reduction and internal fixation (ORIF)|OTHER: Non-surgical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Systemic and Local Vascular Responses to Apelin in the Context of Renin-angiotensin Upregulation
Status: COMPLETED
Conditions: Heart Disease|Heart Failure|Vasodilatation
Interventions: DRUG: Apelin|DRUG: Acetylcholine|DRUG: Sodium nitroprusside|DRUG: Systemic apelin infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Primary Prevention of Cardiovascular Diseases in Childhood and Adolescence: the Role of Physical Activity
Status: TERMINATED
Conditions: Obesity|Hypercholesterolemia|High Blood Pressure|Sedentary Lifestyle
Interventions: OTHER: physical exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The First Clinical Study to Test Safety, Blood Levels and Other Effects of CDP6038 in Healthy Males
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: BIOLOGICAL: CDP6038|BIOLOGICAL: CDP6038|BIOLOGICAL: CDP6038|OTHER: Placebo|OTHER: Placebo|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Effects of Bromelain and Boswellia Serrata Casperome With Centella Asiatica and Vitamins on Edema, Paresthesia and Postoperative Pain After Quadrantectomy With or Without Sentinel Lymph Node Biopsy.
Status: UNKNOWN
Conditions: Breast Cancer Female|Pain, Postoperative
Interventions: DIETARY_SUPPLEMENT: Bromelain/Boswellia Serrata Casperome|DIETARY_SUPPLEMENT: Centella Asiatica/Vitamins|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effects of Food and Cobicistat on Plixorafenib Pharmacokinetics in Healthy Volunteers.
Status: RECRUITING
Conditions: Healthy Volunteer
Interventions: DRUG: Plixorafenib|DRUG: Cobicistat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility Evaluation of CPAP in the Treatment of Obstructive Sleep Apnea Synchrone in the Acute Phase of Stroke
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndrome
Interventions: DEVICE: CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of GL-0817 (With Cyclophosphamide) for the Prevention of Recurrence of Squamous Cell Carcinoma of the Oral Cavity
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Oral Cavity
Interventions: DRUG: GL-0817|DRUG: Hiltonol|DRUG: Sargramostim|DRUG: cyclophosphamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MED in UVB Devices in the Presence and Absence of UV Filter
Status: WITHDRAWN
Conditions: Healthy Participants and/or Patients
Interventions: DEVICE: Psoriashield in the presence of a non-UV absorbing block.|DEVICE: Psoriashield in the presence of a UV absorbing block.|DEVICE: Psoriashield|DEVICE: Xtrac laser in the presence of a non-UV absorbing block.|DEVICE: Xtrac in the presence of a UV absorbing block.|DEVICE: Xtrac laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Antibiotic Use in Distal Hypospadias Repair
Status: COMPLETED
Conditions: Hypospadias
Interventions: OTHER: Randomization to not receive prophylactic antibiotics after surgery.|OTHER: Randomization to receive prophylactic antibiotics after surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Desferal Versus Osveral in Transfusional Iron Overload
Status: COMPLETED
Conditions: Thalassemia|Iron Overload|Transfusion Related Complications
Interventions: DRUG: osveral|DRUG: Desferal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A First-in-Human, Phase 1/2 Study of LAT010 in Patients With Advanced Solid Tumors (LIGHTSPEED-1)
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: LAT010|DRUG: LAT010 + ICI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Extracorporeal Treatment With the Cytosorb-Adsorber for the Reduction of SIRS in Heart Surgery Patients
Status: UNKNOWN
Conditions: Multiple Organ Failure
Interventions: DEVICE: Extracorporeal treatment with the Cytosorb adsorber
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT