pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Toripalimab in Combination With Lenvatinib and TACE for Conversion Therapy in Patients With Potentially Resectable HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Lenvatinib 4 MG Oral Capsule [Lenvima]|DRUG: Toripalimab|PROCEDURE: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Validation of a Deep Learning Algorithm to Evaluate Endoscopic Disease Activity of Ulcerative Colitis.
Status: UNKNOWN
Conditions: Ulcerative Colitis
Interventions: DEVICE: Artificial inteligence associated ulcerative colitis severity scoring system|DEVICE: Conventional human scoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Rebamipide in Subjects With Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: Rebamipide 2% ophthalmic suspension|DRUG: Placebo (vehicle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Evaluation for the Treatment of Allergy Against Grass and Olive Pollen
Status: RECRUITING
Conditions: Rhinitis, Allergic|Rhinoconjunctivitis|Asthma, Allergic
Interventions: BIOLOGICAL: 10,000 MG01 + 10,000 T517|BIOLOGICAL: 30,000 MG01 + 10,000 T517|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Xyrem® in Subjects With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: Xyrem®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment With BIBW 2992, Irreversible Inhibitor of EGFR and HER-2 in Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer|EGFR|HER-2
Interventions: DRUG: BIBW 2992
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabetic Gastroparesis Efficacy/Safety Study of TZP-102
Status: TERMINATED
Conditions: Diabetic Gastroparesis
Interventions: DRUG: 10 mg TZP-102|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sequence of Symptom Change During AUD or PTSD Treatment for Comorbid PTSD/AUD
Status: UNKNOWN
Conditions: PTSD|Alcohol Abuse|Alcohol Dependence
Interventions: BEHAVIORAL: Cognitive Processing Therapy (CPT)|BEHAVIORAL: Relapse Prevention (RP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oblique Versus Transverse Orientation Approach for Internal Jugular Venous Cannulation in Pediatrics
Status: COMPLETED
Conditions: Heart; Surgery, Heart, Functional Disturbance as Result|Pediatric ALL
Interventions: PROCEDURE: internal jugular venous cannulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GLUcose Transport and REnalPROtection in Chronic Kidney Disease
Status: RECRUITING
Conditions: Chronic Kidney Disease|Diabetes Mellitus, Type 2|Hypertension
Interventions: DRUG: Dapagliflozin 10mg Tab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Mifepristone and Eribulin in Patients With Metastatic Triple Negative Breast Cancer or Other Specified Solid Tumors
Status: COMPLETED
Conditions: Breast Cancer|Ovarian Epithelial Cancer Recurrent|Sarcoma|Non-small Cell Lung Cancer|Carcinoma, Transitional Cell|Prostate Cancer|Prostatic Neoplasms
Interventions: DRUG: Mifepristone and Eribulin in combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Stem/Stromal Cellular Stromal Vascular Fraction (cSVF) In Frailty-Aging Processes
Status: UNKNOWN
Conditions: Frail Elderly Syndrome|Aging|Degenerative Disease
Interventions: PROCEDURE: Microcannula harvest adipose stromal tissues|DEVICE: Centricyte 1000|PROCEDURE: Sterile Normal Saline IV Deployment of cSVF|DRUG: Liberase|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Vaccine Counseling Skills Among Residents Using Educational Modules and Standardized Patient Encounters
Status: RECRUITING
Conditions: Vaccine Refusal|Vaccine-Preventable Diseases|Physician-Patient Relations
Interventions: OTHER: Immersive resident education|OTHER: Standardized patient (SP) encounter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Neuroimaging Guided and Robot-assisted rTMS for Suicidal Ideation of Depression
Status: UNKNOWN
Conditions: Suicidal Ideation|Depression
Interventions: COMBINATION_PRODUCT: Robot-assisted accelerated iTBS-1800 combined with serotonin-norepinephrine reuptake inhibitors(SNRIs)|COMBINATION_PRODUCT: Robot-assisted accelerated iTBS-600 combined with serotonin-norepinephrine reuptake inhibitors(SNRIs)|COMBINATION_PRODUCT: Sham accelerated iTBS combined with serotonin-norepinephrine reuptake inhibitors(SNRIs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Triamcinolone Acetonide Injections in Mild-to-moderate Chronic Plaque Psoriasis With a Novel Needle-free Drug-delivery System
Status: COMPLETED
Conditions: Psoriasis
Interventions: DEVICE: Med-Jet|OTHER: Traditional Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Long-Term Safety Study of TA-7284 in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: TA-7284-Low|DRUG: TA-7284-High
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Therapeutic Touch on Colic Symptoms in Infantile Colic Infants: A Randomized Controlled Study
Status: COMPLETED
Conditions: Infantile Colic|Therapeutic Touch
Interventions: OTHER: Therapeutic Touch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clopidogrel With Aspirin in High-risk Patients With Acute Non-disabling Cerebrovascular Events II
Status: COMPLETED
Conditions: Stroke|Transient Ischemic Attack
Interventions: DRUG: Ticagrelor and Aspirin|DRUG: Clopidogrel and Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Multi-Center, Open-Label Study of Surufatinib (HMPL-012) in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Tumors
Interventions: DRUG: surufatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Dystrophin Levels in Participants With Nonsense Mutation Duchenne Muscular Dystrophy (nmDMD) Who Have Been Treated With Ataluren
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: Ataluren
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cardiac Function in Swimming-Induced Pulmonary Edema (SIPE)
Status: RECRUITING
Conditions: Swimming Induced Pulmonary Edema (SIPE)|Pulmonary Edema|Lung Diseases|Heart Function Tests
Interventions: DIAGNOSTIC_TEST: Echocardiography|DIAGNOSTIC_TEST: Electrocardiogram (ECG)|DIAGNOSTIC_TEST: Cardiac biomarkers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MIRA Clinical Learning Environment (MIRACLE): Lung
Status: RECRUITING
Conditions: Lung Cancer
Interventions: OTHER: Application of ILD prediction machine learning model to planning imaging|OTHER: Routine, automatic presentation of ILD risk level for evaluation by the clinician.|OTHER: Application of SGR machine learning model to diagnostic and planning imaging|OTHER: Routine estimation of tumor specific growth rate (SGR) for lesions being considered for radiation therapy presented to clinician.|OTHER: Application of CBCT machine learning model to on-treatment imaging|OTHER: Routine monitoring of lung density changes during the course of treatment presented to clinician.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: AEE788 and Everolimus in Treating Patients With Recurrent or Relapsed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: AEE788|DRUG: everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating PAZ-417 in Cerebrospinal Fluid in Subjects With Alzheimer's Disease
Status: TERMINATED
Conditions: Alzheimer Disease
Interventions: DRUG: Placebo|DRUG: PAZ-417
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Neoadjuvant PD-1 Plus TIGIT Blockade in Patients With Cisplatin-Ineligible Operable High-Risk Urothelial Carcinoma
Status: RECRUITING
Conditions: Metastatic Malignancy
Interventions: DRUG: Atezolizumab|DRUG: Tiragolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sleep Innovations for Preschoolers With Arthritis (SIPA): Developing and Pilot Testing of a Self-Management Intervention
Status: COMPLETED
Conditions: Juvenile Idiopathic Arthritis
Interventions: BEHAVIORAL: Sleep Innovations for Preschoolers with Arthritis (SIPA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ixazomib Maintenance Study in Patients With AL Amyloidosis
Status: ACTIVE_NOT_RECRUITING
Conditions: AL Amyloidosis
Interventions: DRUG: Ixazomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Tricor, Avandia, or Weight Loss to Lower Cardiovascular Risk Factors in People With High Triglycerides.
Status: COMPLETED
Conditions: Insulin Resistance|Hypertriglyceridemia
Interventions: DRUG: Rosiglitazone|DRUG: Fenofibrate|BEHAVIORAL: Weight Loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Investigate the Effect of Aerobic Exercise on Neurophysiological Values and Functionality in Individuals With Multiple Sclerosis.
Status: UNKNOWN
Conditions: Multiple Sclerosis, Relapsing-Remitting|FNDC5|Irisin Hormone|Aerobic Exercise|EMG: Axonal Abnormality
Interventions: OTHER: Aerobic Exercise|OTHER: Frenkel coordination exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Benazepril HCl 40 mg Tablets, Fed
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Benazepril HCl 40 mg Tablets|DRUG: Lotensin® 40 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: CSL200 Gene Therapy in Adults With Severe Sickle Cell Disease
Status: TERMINATED
Conditions: Anemia, Sickle Cell
Interventions: BIOLOGICAL: Autologous enriched CD34+ cell fraction that contains CD34+ cells transduced with lentiviral vector encoding human γ-globinG16D and short-hairpin RNA734
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TREAT NL (TREatment of ATopic Eczema, the Netherlands) Registry: Dutch National Registry for Patients With Moderate-to-severe Atopic Eczema on Photo- or Systemic Therapies
Status: RECRUITING
Conditions: Moderate-to-severe Atopic Eczema
Interventions: OTHER: No study-specific intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Differential Efficacy of Corticosteroid Solutions for Non-Operative Treatment of Digit Flexor Tenosynovitis
Status: TERMINATED
Conditions: Trigger Finger
Interventions: DRUG: Triamcinolone Acetonide 40mg/mL|DRUG: Triamcinolone Acetonide 10mg/mL|DRUG: Dexamethasone 4 mg/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Ear Vagus Nerve Stimulator on Patients With IBS
Status: NOT_YET_RECRUITING
Conditions: Irritable Bowel Syndrome
Interventions: DEVICE: Vagus nerve stimulation for 8 weeks|DEVICE: Vagus nerve stimulation for the first 4 weeks|DEVICE: Vagus nerve stimulation for the last 4 weeks|DEVICE: Pseudostimulus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Therapeutic Equivalence of Fluticasone Propionate Pressurized Metered Dose Inhaler, 110 mcg, to Flovent® HFA 110 mcg
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone propionate pressurized metered dose inhaler|DRUG: Flovent HFA pressurized metered dose inhaler|DRUG: Placebo pressurized metered dose inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Aromatherapy on the Insulin Injection Pain
Status: COMPLETED
Conditions: Pain|Aromatherapy|Subcutaneous Injections
Interventions: OTHER: Topically Administered Lavender Aromatherapy|OTHER: Topically Administered Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Papaverine and Oxytocin vs Oxytocin Alone in Labor Induction
Status: NOT_YET_RECRUITING
Conditions: Induced; Birth|Labor Onset and Length Abnormalities
Interventions: DRUG: Papaverine|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics of a Single Dose of Tafenoquine Co-administered With Either Artemether + Lumefantrine or Dihydroartemisinin + Piperaquine Tetraphosphate
Status: COMPLETED
Conditions: Malaria, Vivax
Interventions: DRUG: Tafenoquine|DRUG: Dihydroartemisinin + Piperaquine tetraphosphate|DRUG: Artemether + Lumefantrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Interventional Study on Early Screening for Lung Cancer Using Liquid Biopsy
Status: NOT_YET_RECRUITING
Conditions: Liquid Biopsy for Early Screening of Lung Cancer
Interventions: DIAGNOSTIC_TEST: Liquid Biopsy Early Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Description of Eosinophilic Pneumonia in BJI/PJI Treated by Daptomycin
Status: UNKNOWN
Conditions: Dactinomycin Adverse Reaction|Bone and Joint Infection
Interventions: OTHER: Description of eosinophilic pneumonia due to daptomycine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of HyQvia (Immunoglobulin 10% With Recombinant Hyaluronidase) in Multifocal Motor Neuropathy (MMN)
Status: COMPLETED
Conditions: Multifocal Motor Neuropathy
Interventions: DRUG: HyQvia|DRUG: Subcuvia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Serplulimab+Regorafenib +Hepatic Artery Bicarbonate Infusion in Patients With Colorectal Cancer and Liver Metastases
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer|Liver Metastases
Interventions: DRUG: Serplulimab+Regorafenib|DRUG: Hepatic Artery Bicarbonate Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vascular Response of Orsiro vs. Xience Drug-Eluting Stents for Treating Coronary Bifurcation Lesions
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: Orsiro stent|DEVICE: Xience stent|DEVICE: Any drug-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yttrium-90 Carbon Microspheres in Patients With Unresectable Colorectal Liver Metastases
Status: RECRUITING
Conditions: Unresectable Colorectal Liver Metastases
Interventions: COMBINATION_PRODUCT: Selective internal radiation therapy (SIRT) with yttrium-90 carbon microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) in Adolescents in Non-Endemic Area(s)
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: Tetravalent Dengue Vaccine (TDV)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess AC220 Given in Combination With Induction and Consolidation Therapy in Newly Diagnosed Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: AC220|DRUG: daunorubicin|DRUG: cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optical Coherence Tomography-Guided PCI With Single-Antiplatelet Therapy
Status: COMPLETED
Conditions: Non ST Segment Elevation Acute Coronary Syndrome
Interventions: DRUG: Prasugrel 10mg|DRUG: Ticagrelor 90mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fludarabine and Total Body Irradiation 800 Centigray (cGy) or 1125 cGy For Allogeneic Stem Cell Transplant Using Graft Versus Host Disease Prophylaxis With Post-Transplant Cyclophosphamide and Tacrolimus, Without Mycophenolate Mofetil
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematologic Neoplasms
Interventions: OTHER: Omission of the drug mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Ilioinguinal/Iliohypogastric Nerve Block
Status: COMPLETED
Conditions: Inguinal Hernia Repair|Pain, Postoperative
Interventions: DRUG: Levo-bupivacaine 0.25
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Usefulness of Myocardial Work IndeX in ExtraCorporeal Membrane Oxygenation Patients
Status: NOT_YET_RECRUITING
Conditions: Echocardiography|Mechanical Circulatory Support|Myocardial Failure|Cardiogenic Shock|Extracorporeal Membrane Oxygenation Complication
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Computer Guided Versus Conventional Augmentation Using Bone Ring
Status: UNKNOWN
Conditions: Bone Resorption
Interventions: PROCEDURE: Computer Guided Stent Augmentation|PROCEDURE: Free Hand Augmentation|DRUG: Platelet-rich fibrin (PRF)|DEVICE: implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: KeySteps@JC - Early Child Intervention
Status: COMPLETED
Conditions: Lower Socioeconomic Background
Interventions: BEHAVIORAL: Child interactive intervention|BEHAVIORAL: Family Empowerment|BEHAVIORAL: Access to Community Hub and its services|OTHER: Enhancement to the kindergartens|OTHER: Health education, screening, and support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Tolerability of Topically Applied Bovine Lung Surfactant on Intact Skin
Status: COMPLETED
Conditions: Skin and Connective Tissue Diseases
Interventions: DRUG: Surfactants|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-Guided Photoacoustic Imaging for the Detection of Metastases in Inguinal Lymph Nodes
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Neoplasm
Interventions: PROCEDURE: Fine-Needle Aspiration|PROCEDURE: Lymph Node Biopsy|PROCEDURE: Photoacoustic Imaging|PROCEDURE: Ultrasound|DEVICE: Multispectral optoacoustic tomography (MSOT) acuity instrument
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Fluzoparib in Combination With Camrelizumab and Temozolomide in Advanced Melanoma
Status: NOT_YET_RECRUITING
Conditions: Melanoma
Interventions: DRUG: Fluzoparib Camrelizumab Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-World Experience of Athletes Treated With SAM
Status: COMPLETED
Conditions: Pain, Chronic|Pain, Acute|Sport Injury|Soft Tissue Injuries|Arm Injury|Back Pain|Tendon Injuries|Muscle Injury
Interventions: DEVICE: Low Intensity Continuous Ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of SPG601 in Adult Men With Fragile X Syndrome
Status: RECRUITING
Conditions: Fragile X Syndrome
Interventions: DRUG: SPG601|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of BRIMOCHOL™, BRIMOCHOL™ F, and Carbachol in Subjects With Emmetropic Phakic and Pseudophakic Presbyopia
Status: COMPLETED
Conditions: Presbyopia
Interventions: DRUG: BRIMOCHOL™|DRUG: BRIMOCHOL™ F|DRUG: Carbachol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination With Durvalumab Versus Nivolumab Monotherapy in Participants With Select Advanced Malignancies
Status: COMPLETED
Conditions: Select Advanced Malignancies|Kidney Cancer|Clear Cell Renal Cell Carcinoma
Interventions: BIOLOGICAL: MEDI0680|BIOLOGICAL: Durvalumab|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study Assessing the Efficacy and Safety of Macitentan in Fontan-palliated Subjects
Status: COMPLETED
Conditions: Congenital Heart Disease
Interventions: DRUG: Macitentan 10 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CLEAR SIGHT: A Trial of Non-Mydriatic Ultra-Widefield Retinal Imaging to Screen for Diabetic Eye Disease
Status: COMPLETED
Conditions: Diabetes Mellitus|Diabetic Retinopathy
Interventions: DEVICE: Optos 200Tx|DEVICE: Zeiss Cirrus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Simplified Selective Digestive Tract Decontamination for the Prevention of Intensive Care Unit Acquired Infections
Status: UNKNOWN
Conditions: Bacteremia Associated With Intravascular Line|Ventilator Associated Pneumonia|Bacteremia
Interventions: DRUG: Neomycin Colistin Nystatin Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Non-invasive Neuromodulation NESA Through Somatosensory Evoked Potentials and Sympathetic-cutaneous Responses
Status: NOT_YET_RECRUITING
Conditions: Healthy Volunteers
Interventions: DEVICE: Non-invasive Neuromodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Efficacy Of Mapping For Cognitive Prostate Biopsy
Status: RECRUITING
Conditions: Prostate Cancer|Prostate Adenocarcinoma|Prostatic Neoplasms|Prostate Disease|Prostate Cancer Stage
Interventions: PROCEDURE: Performing cognitive prostate biopsy with a radiologist's guidance with map|PROCEDURE: Performing cognitive prostate biopsy without a radiologist's guidance with map
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: STOPping Anticoagulation for Isolated or Incidental Subsegmental Pulmonary Embolism
Status: UNKNOWN
Conditions: Subsegmental Pulmonary Embolism Nos
Interventions: OTHER: No treatment|DRUG: Warfarin|DRUG: direct oral anticoagulants|DRUG: Low molecular weight heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Monitoring for Motor Pathway in Brain Tumor Surgery Within Eloquent Area
Status: COMPLETED
Conditions: Glioma, Motor Pathway
Interventions: PROCEDURE: diffusion tensor tractography neuronavigation and intraoperative subcortical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Managing Alcoholism in People Who Do Not Respond to Naltrexone
Status: COMPLETED
Conditions: Alcoholism
Interventions: DRUG: Naltrexone|DRUG: placebo|BEHAVIORAL: Medication Management (MM)|BEHAVIORAL: Combined Behavioral Intervention (CBI)|BEHAVIORAL: Telephone Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Level Laser in Isolated Cleft Palate Repair Versus Surgical Correction Without LLL in Healing Process
Status: UNKNOWN
Conditions: Cleft Palate Children|Laser
Interventions: OTHER: low level laser|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Engagement and Clinical Impact of the Teleo Virtual Therapy Platform in Clinical Settings - Pilot RCT
Status: NOT_YET_RECRUITING
Conditions: Anxiety Disorders|Mood Disorders
Interventions: OTHER: Teleo|OTHER: Standard videoconferencing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Hamstring Tightness
Status: COMPLETED
Conditions: Hamstring Tightness
Interventions: PROCEDURE: Dry needling|PROCEDURE: Sham needling|PROCEDURE: Blunt needle placement|OTHER: Standard hamstring stretching exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pediatric Inguinal Hernia Repair: Are Muscle Relaxants Necessary? Endotracheal Intubation vs Laryngeal Mask Airway
Status: COMPLETED
Conditions: Inguinal Hernia|Endotracheal Intubation|Laryngeal Mask|Muscle Relaxants
Interventions: DEVICE: ETT|DEVICE: Proseal LMA|DRUG: Rocuronium|OTHER: No Muscle Relaxant|DRUG: Rocuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Nutritional Intervention Program in Malnourished Patients Admitted for Heart Failure
Status: TERMINATED
Conditions: Heart Failure|Malnutrition|Nutritional Intervention|Mortality
Interventions: OTHER: Nutritional intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Er,Cr:YSGG Laser-aided Fiberotomy in the Prevention of the Lower Incisors Rotational Relapse
Status: UNKNOWN
Conditions: Rotated Teeth
Interventions: PROCEDURE: Er,Cr:YSGG laser-aided CSF|PROCEDURE: Conventional CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Providence Nighttime Brace for the Treatment of Adolescence Idiopathic Scoliosis
Status: UNKNOWN
Conditions: Adolescence Idiopathic Scoliosis
Interventions: DEVICE: Providence Nighttime Bracing System|DEVICE: Providence Nighttime Bracing System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Gut Health Effects of Heat-killed Post-biotics in Overweight and Obese Adults
Status: RECRUITING
Conditions: Gastrointestinal Dysfunction
Interventions: DIETARY_SUPPLEMENT: EF2001|DIETARY_SUPPLEMENT: beLP1|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Geriatric Determinants of General Repercussion of Radiotherapy for Patient Over 75 Years With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: OTHER: geriatric assessment and quality of life|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Efficacy of Delpazolid as Add-on Therapy in Refractory Mycobacterium Abscessus Complex
Status: RECRUITING
Conditions: Nontuberculous Mycobacterium Infection|Mycobacterium Abscessus Infection
Interventions: DRUG: Delpazolid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Duration of Dry Needling on Muscles Strength of Flexor Forearm Muscles of Dominant Hand in Healthy Subjects
Status: COMPLETED
Conditions: Dry Needling
Interventions: DEVICE: dry needling|OTHER: kinesio taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploring Effectiveness and Mechanism of Change of an Implementation Strategy on Guideline Implementation in Schools
Status: COMPLETED
Conditions: Mental Disorder|Stress
Interventions: BEHAVIORAL: Educational meeting|BEHAVIORAL: Implementation team|BEHAVIORAL: Workshops|BEHAVIORAL: Plan-Do-Study-Act improvement cycles|BEHAVIORAL: Internal facilitator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effectiveness of Full-thickness Palatal Graft Technique (FTPGT) in Obtaining Complete Root Coverage
Status: COMPLETED
Conditions: Gingival Recession
Interventions: PROCEDURE: FTPGT treated patients|PROCEDURE: CAF+SCTG treated patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of and Immune Response to a DNA Vaccine and a Recombinant HIV-1-MVA Vaccine, Separately and in Combination, in Healthy Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: EP-1233|BIOLOGICAL: MVA-mBN32
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: To Motivate Elderly to Move
Status: COMPLETED
Conditions: Geriatric Disorder
Interventions: BEHAVIORAL: Regulatory frame: prevention|BEHAVIORAL: Regulatory frame: promotion|BEHAVIORAL: Regulatory frame: not implied
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Human Papilloma Virus (HPV) Vaccine Immunogenicity and Safety Trial in Young and Adult Women With GSK Biologicals' HPV-16/18
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: BIOLOGICAL: Cervarix
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Pilot-Study of ProEndoTecc Vascular Grafts as Superficial Femoral Artery Bypass / Interponate
Status: TERMINATED
Conditions: Peripheral Arterial Disease|Peripheral Vascular Disease
Interventions: DEVICE: ProEndoTecc Vascular Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Subcutaneous FEntanyl titRation: RApid Achievement of Adequate Exposure When Treating Cancer-Related paIn.
Status: RECRUITING
Conditions: Cancer Pain
Interventions: DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Betamethasone Versus Ketorolac Injection for the Treatment of DeQuervains Tenosynovitis
Status: ACTIVE_NOT_RECRUITING
Conditions: DeQuervain Tendinopathy
Interventions: DRUG: betamethasone|DRUG: Ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Treprostinil to Treat Interstitial Lung Disease Pulmonary Hypertension
Status: ENROLLING_BY_INVITATION
Conditions: Pulmonary Arterial Hypertension|Interstitial Lung Disease|Healthy Adults
Interventions: DRUG: Treprostinil|DIAGNOSTIC_TEST: Right Heart Catheterization (RHC) while exercising|DIAGNOSTIC_TEST: Optional Muscle Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Neurostimulation on Patterns of Brain Electrical Activity in Patients With Tinnitus
Status: UNKNOWN
Conditions: Tinnitus
Interventions: DEVICE: Transcranial Direct Current Stimulation|DEVICE: Sham Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Study Between AZD3480 and Warfarin
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: AZD3480|DRUG: Placebo|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Surmounting Withdrawal to Initiate Fast Treatment With Naltrexone
Status: COMPLETED
Conditions: Opioid-use Disorder
Interventions: OTHER: Standard Induction Procedure (SP)|OTHER: Rapid Induction Procedure (RP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel and Pegylated Liposomal Doxorubicin for Treatment of HIV-related Kaposi Sarcoma
Status: NOT_YET_RECRUITING
Conditions: Kaposi Sarcoma|HIV-1-infection|AIDS-related Kaposi Sarcoma
Interventions: DRUG: Pegylated liposomal doxorubicin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polipill and RiscOMeter to Prevent StrOke and CogniTive ImpairmEnt (PROMOTE)
Status: RECRUITING
Conditions: Stroke|Cognitive Decline
Interventions: DRUG: Drug Capsule (Valsartan + Amlodipine + Rosuvastatin)|BEHAVIORAL: Stroke Riskometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tinnitus rTMS 2013
Status: COMPLETED
Conditions: Tinnitus
Interventions: DEVICE: E-fied navigated rTMS|DEVICE: non-navigated rTMS|DEVICE: sham E-field navigated rTMS|DEVICE: Navigated rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Ketone Bodies on Cognition in Type 2 Diabetes
Status: COMPLETED
Conditions: Type2 Diabetes|Ketonemia|Cognitive Change
Interventions: DRUG: Ketone infusion|DRUG: Saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Double-blind, Randomized Controlled Study in CD20-positive Diffuse B Cell Non-Hodgkin's Lymphoma Subjects
Status: COMPLETED
Conditions: DLBCL
Interventions: BIOLOGICAL: TL011|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Karydakis Procedure Versus Excision With Healing by Secondary Intention (EHSI) in Sacrococcygeal Pilonidal Sinus
Status: COMPLETED
Conditions: Pilonidal Sinus|Pilonidal Cyst
Interventions: PROCEDURE: karydakis flap|PROCEDURE: laying open
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention for Newly Diagnosed Youth With HIV
Status: COMPLETED
Conditions: HIV
Interventions: BEHAVIORAL: "Adolescents Coping, Connecting, Empowering, and Protecting Together" (Project ACCEPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Therapy of Preconditioned Autologous BMMSCs for Patients With Ischemic Heart Disease
Status: UNKNOWN
Conditions: Myocardial Infarction|Acute Myocardial Infarction|Ischemic Cardiomyopathy
Interventions: BIOLOGICAL: BMMSCs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Participants With Later-onset Spinal Muscular Atrophy (SMA)
Status: COMPLETED
Conditions: Spinal Muscular Atrophy
Interventions: DRUG: Nusinersen|PROCEDURE: Sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MONITOR-CKD5 - Multi-level Evaluation of Anaemia Treatment, Outcomes, and Determinants in Chronic Kidney Disease Stage 5
Status: COMPLETED
Conditions: Chronic Kidney Disease|End-stage Renal Disease|Anaemia
Interventions: DRUG: Recombinant human erythropoietin alfa (biosimilar)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Electroanatomical Mapping of Patients Undergoing Catheter Ablation Procedures Using Rhythmia Mapping System and Catheter
Status: COMPLETED
Conditions: Cardiac Arrhythmias
Interventions: DEVICE: Rhythmia Mapping System and the Rhythmia Mapping Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hypoglycemic Efficacy of Greenyn Momordica Charantia Extracts in Diabetic Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DIETARY_SUPPLEMENT: Greenyn Momordica charantia extracts|DIETARY_SUPPLEMENT: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Underwater Endoscopic Mucosal Resection Versus Metal Clips With Hot Snare Polypectomy for Resection of Big Pedunculated Colorectal Polyps：a Randomized Controlled Trial
Status: RECRUITING
Conditions: Pedunculated Colorectal Polyps|Haemorrhage
Interventions: OTHER: underwater endoscopic mucosal resection|OTHER: hot snare polypectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Investigate the Efficacy of Olmesartan in Paroxysmal Atrial Fibrillation
Status: COMPLETED
Conditions: Heart Disease|Arrhythmia|Atrial Fibrillation
Interventions: DRUG: Olmesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cryoanalgesia Aplication Time Optimization During Nuss Procedure
Status: RECRUITING
Conditions: Funnel Chest|Excavatum, Pectus
Interventions: PROCEDURE: shorter cryoanalgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Early Cardioprotective Effect of Sevoflurane
Status: COMPLETED
Conditions: Coronary Artery Disease|Off Pump Coronary Artery Bypass Surgery
Interventions: DRUG: Sevoflurane|DRUG: propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: The Change in Cutaneous Temperature When Using Acupuncture at TB-3 and BL-65 Acupoints in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: PROCEDURE: Fine needle acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Genomic Grade Index (GGI): Feasibility in Routine Practice and Impact on Treatment Decisions in Early Breast Cancer
Status: COMPLETED
Conditions: Invasive Breast Cancer
Interventions: OTHER: Sampling of tumor tissue|OTHER: Sampling of tumor tissue after breast cancer surgery|PROCEDURE: Sampling of tumor tissue after breast cancer surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vildagliptin Compared to Pioglitazone in Combination With Metformin in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Metabolic Control in Type 1 Diabetes - The Automatic Bolus Calculator Flash Study
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DEVICE: Carbohydrate counting, automated bolus calculation|DEVICE: Flash glucose monitoring (FGM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: (Hyoscine Butylbromide) for Abdominal Pain Associated With Cramping on Demand Basis
Status: COMPLETED
Conditions: Abdominal Pain
Interventions: DRUG: Placebo|DRUG: HBB 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Masticatory Side Change and Masticatory Function.
Status: COMPLETED
Conditions: Chewing Problem|Mastication Disorder
Interventions: BEHAVIORAL: F|BEHAVIORAL: R|BEHAVIORAL: L|BEHAVIORAL: A1|BEHAVIORAL: A3|BEHAVIORAL: A5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Subarachnoid Block Versus Ultrasound Guided Transversalis Fascia Plane Block for Postoperative Analgesia of Inguinal Hernia Repair in Adults
Status: RECRUITING
Conditions: Postoperative Analgesia of Inguinal Hernia Repair in Adults
Interventions: DRUG: bupivacaine injection by ultrasound guided transversalis fascia plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: A Study Investigating the Bioavailability of a High Concentration Liquid Formulation Versus a Reference Lyophilized Formulation of Gantenerumab in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: gantenerumab|DRUG: gantenerumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Ultrasound-Guided Dextrose Prolotherapy in Ehlers-Danlos Syndrome Patients
Status: NOT_YET_RECRUITING
Conditions: Ehlers-Danlos Syndrome|Low Back Pain|Sacroiliac Instability
Interventions: DRUG: Dextrose 50% Intravenous Solution|DRUG: Lidocaine 1% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sintilimab to Prevent High-risk Oral Premalignant Lesions Cancerization
Status: UNKNOWN
Conditions: Oral Cavity Cancer|Mouth Neoplasm|Precancerous Conditions
Interventions: DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Interleukin-2 Combined With Monoclonal Antibody Therapy in Treating Patients With Kidney, Bladder, or Lung Cancer That Has Not Responded to Previous Treatment
Status: COMPLETED
Conditions: Bladder Cancer|Kidney Cancer|Lung Cancer
Interventions: BIOLOGICAL: tucotuzumab celmoleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT