pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Etoposide, Prednisone, Vincristine Sulfate, Cyclophosphamide, and Doxorubicin in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Lymphoblastic Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Dasatinib|DRUG: Doxorubicin|DRUG: Etoposide|DRUG: Imatinib Mesylate|OTHER: Laboratory Biomarker Analysis|DRUG: Prednisone|BIOLOGICAL: Rituximab|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose-escalation Clinical Trial After Multiple Dosing of HL217 Eye Drop in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Cohort 1: HL217 Ophathalmic Solution BID|DRUG: Cohort 2: HL217 Ophathalmic Solution QID|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Transcranial Magnetic Stimulation (TMS) for Patients With Treatment Resistant Auditory Verbal Hallucination
Status: UNKNOWN
Conditions: Hallucinations, Verbal Auditory
Interventions: DEVICE: Transcranial Magnetic Stimulation|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Itacitinib for the Prevention of Graft Versus Host Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematologic and Lymphocytic Disorder
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Busulfan|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Itacitinib|DRUG: Tacrolimus|DRUG: Thiotepa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Pharmacokinetics of Oral F901318 (Fluconazole and Posaconazole) IN Aml Leukaemia
Status: WITHDRAWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: F901318 with fluconazole low dose|DRUG: F901318 with fluconazole high dose|DRUG: F901318 with posaconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Rotator Cuff Tears With Platelet Rich Plasma
Status: WITHDRAWN
Conditions: Rotator Cuff Tears|Rotator Cuff Tendinitis
Interventions: BIOLOGICAL: Platelet Rich Plasma (PRP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Voriconazole vs. Amphotericin B in the Treatment of Invasive Aspergillosis
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome|Aspergillosis|HIV Infections|Immunologic Deficiency Syndromes|Neutropenia
Interventions: DRUG: Voriconazole|DRUG: Amphotericin B
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Medical Cannabis Oil for Treatment of Agitation and Disruptive Behaviors in Subjects With Dementia.
Status: TERMINATED
Conditions: Agitation,Psychomotor|Disruptive Behavior|Dementia|Alzheimer Disease
Interventions: DRUG: Medical Cannabis|DRUG: Placebo Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vulvar Contact Dermatitis Resulting From Urine Incontinence
Status: WITHDRAWN
Conditions: Urinary Incontinence|Vulvar Pruritus|Vulvar Contact Dermatitis
Interventions: OTHER: Questionnaires, gynecological exam , vaginal smear, and measurement of urine leakage
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Study of Tusamitamab Ravtansine (IBI126) Combined With Sintilimab and Tusamitamab Ravtansine (IBI126) Combined With Sintilimab Plus Platinum-based Chemotherapy and Pemetrexed in Subjects With CEACAM5 Positive Expression Advanced/Metastatic Non-squamous Non-small-cell Lung Cancer (NSQ NSCLC)
Status: TERMINATED
Conditions: Non-squamous Non-small-cell Lung Cancer
Interventions: DRUG: Tusamitamab ravtansine+Sintilimab+Carboplatin or Cisplatin+Pemetrexed|DRUG: Sintilimab+Carboplatin or Cisplatin+Pemetrexed|DRUG: Tusamitamab ravtansine+Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effect of High Intensity Interval Exercise in Patients With Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: OTHER: HIT 1:1|OTHER: HIT 1:2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Drugs for Control of Emetic Attacks During Caesarean Delivery
Status: NOT_YET_RECRUITING
Conditions: Emetic Attacks During Caesarean Delivery With Spinal Anesthesia
Interventions: DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Feasibility of a Diet Intervention for Juvenile Arthritis
Status: NOT_YET_RECRUITING
Conditions: Arthritis, Juvenile|Arthritis, Childhood|Juvenile Idiopathic Arthritis
Interventions: OTHER: Diet intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate Zoledronic Acid on Quality of Life and Skeletal-related Events as Adjuvant Treatment in Patients With Hormone-naïve Prostate Cancer and Bone Metastasis Who Have Undergone Orchiectomy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Alogliptin on Glycemic Control in Subjects With Type 2 Diabetes.
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Alogliptin|DRUG: Alogliptin|DRUG: Alogliptin|DRUG: Alogliptin|DRUG: Alogliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Hormonal STatus on Energy Expenditure and Feeding behAvior in woMen(ESTEAM)
Status: NOT_YET_RECRUITING
Conditions: Energy Expenditure, Appetite, Energy Intake, Food Reward Menopause Transition
Interventions: BEHAVIORAL: Walk test and meal test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of Paclitaxel, Estramustine Phosphate and Thalidomide for Patients With Metastatic Androgen-Independent Prostate Carcinoma
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Estramustine|DRUG: Thalidomide|DRUG: Paclitaxel (Taxol)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Food Effect on the Pharmacokinetics of Rebamipide in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Rebamipide SR 150mg after high-fat meal|DRUG: Rebamipide SR 150mg under fasting condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: In Vivo Evaluation of NC65 - Vita D-Light SKIN ADAPTOGEN AND SEBUM BALANCE EFFICACY
Status: COMPLETED
Conditions: SKIN ADAPTOGEN AND SEBUM BALANCE EFFICACY
Interventions: OTHER: Corthellus Shiitake(Mushroom) Extract|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Interval Compressed Regimen Using Four-drugs for Osteosarcoma
Status: UNKNOWN
Conditions: Osteosarcoma|Feasibility|Treatment Response|Biomarker
Interventions: DRUG: Poor responder group adjuvant chemotherapy|DRUG: Good responder group adjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose (MAD) Combination in Subjects With Multiple Myeloma
Status: COMPLETED
Conditions: Advanced Cancer, Various, NOS
Interventions: DRUG: BMS-833923|DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Types of Biopsy in Suspicious Axillary Lymph Nodes
Status: SUSPENDED
Conditions: Breast Neoplasms
Interventions: DEVICE: Cryo-assisted core needle biopsy|DEVICE: FNA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Safety and Efficacy of Nexalin Trans-cranial Electrical Stimulation Stimulation for the Treatment of Depression
Status: COMPLETED
Conditions: Depression
Interventions: DEVICE: Nexalin Based Trans-Cranial Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Real-World Data Study of Troriluzole-Treated Patients With Spinocerebellar Ataxia (SCA) Compared to a Matched Natural History Control
Status: ENROLLING_BY_INVITATION
Conditions: Spinocerebellar Ataxias
Interventions: DRUG: BHV-4157
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot Study To Investigate The Effect Of Concurrent Antacid Administration On The Bioavailability Of Six Experimental Formulations Of Palbociclib
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Palbociclib Alone|DRUG: Palbociclib + Rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Basal Cell Carcinoma Chemoprevention Trial
Status: NOT_YET_RECRUITING
Conditions: Basal Cell Carcinoma
Interventions: DRUG: 5% Imiquimod cream|DRUG: Placebo Vehicle Control Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Local Anesthesia Versus Saline Serum in Surgical Incision of Colorectal or Hepatic Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Surgery|Postoperative Complications
Interventions: DRUG: ropivacaine|DRUG: saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-HIV Treatment Interruptions in HIV Infected Adults in South Africa
Status: COMPLETED
Conditions: HIV Infections
Interventions: BEHAVIORAL: Structured treatment interruption|DRUG: Lamivudine|DRUG: Lopinavir/Ritonavir|DRUG: Stavudine|BIOLOGICAL: Rabies de novo antigen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lixivaptan in the Treatment of Autosomal Dominant Polycystic Kidney Disease
Status: TERMINATED
Conditions: Autosomal Dominant Polycystic Kidney|ADPKD
Interventions: DRUG: Lixivaptan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Histology Study of Biostimulatory Activity of Injectable Poly-L-Lactic Acid (Sculptra Aesthetic)
Status: UNKNOWN
Conditions: Nasolabial Fold|Facial Wrinkles
Interventions: DEVICE: Sculptra Aesthetic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Modified Robert Jones Bandages on Reducing Invisible Blood Loss After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Blood Loss
Interventions: PROCEDURE: Modified Robert Jones bandage|PROCEDURE: Non compressive dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diarrhea and Stipsis in Critically Ill Patients (NUTRITI)
Status: COMPLETED
Conditions: Critical Illness|Nutritional and Metabolic Disease|Nutritional Deficiency|ICU Acquired Weakness|Enteral Feeding Intolerance|Diarrhea|Constipation
Interventions: OTHER: ARTIFICIAL NUTRITION
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Efficacy and Safety of Local Anesthetic Infusion With Ropivacaine
Status: TERMINATED
Conditions: Obstruction of Pelviureteric Junction
Interventions: DEVICE: Ropivacaine wound catheter|DEVICE: Saline wound catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treximet Trademark (TM) in the Prevention and Modification of Disease Progression in Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Sumatriptan/Naproxen Sodium|DRUG: Naproxen Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Transanal Transection and Single-stapled Anastomosis (TTSS) in Rectal Cancer Patients
Status: RECRUITING
Conditions: Rectal Cancer|Surgery
Interventions: PROCEDURE: Transanal Transection and Single-Stapled anastomosis (TTSS)|PROCEDURE: Double-stapled Total Mesorectal Excision (TME)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Erythropoietin to Treat Anemia Complicating Chronic Obstructive Pulmonary Disease
Status: WITHDRAWN
Conditions: Anemia|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correlation Between Sorafenib Plasma Concentrations, Toxicity and Disease Control Rate in Patients Treated by Sorafenib for Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma (HCC)
Interventions: BIOLOGICAL: Sorafenib plasma concentration 4 weeks after treatment initiation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ProSTAR: A Study Evaluating CPI-1205 in Patients With Metastatic Castration Resistant Prostate Cancer
Status: UNKNOWN
Conditions: Metastatic Castration Resistant Prostate Cancer (mCRPC)
Interventions: DRUG: CPI-1205|DRUG: Enzalutamide|DRUG: Abiraterone/Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Upright Back Posture Device Study
Status: COMPLETED
Conditions: Back Pain|Postural Low Back Pain|Lower Back Pain
Interventions: DEVICE: Upright Go Device|OTHER: Ergonomic Handout
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Galectin-3 Blockade in Patients With High Blood Pressure
Status: COMPLETED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Modified Citrus Pectin (MCP) vs placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sildenafil in COVID-19
Status: COMPLETED
Conditions: Covid19|SARS-COV2 Infection
Interventions: DRUG: Sildenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of an Intensive Multimodal Educative Program on Behavioral Disorders of Patients With Profound Multiple Disabilities and on the Quality of Life and Feelings of Caregivers
Status: COMPLETED
Conditions: Polyhandicap|Behavior Disorders
Interventions: BEHAVIORAL: Intensive educative management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tannin Specific Natural Extract for COVID-19 Infection
Status: TERMINATED
Conditions: COVID-19|SARS-CoV 2|Coronavirus Infection
Interventions: DIETARY_SUPPLEMENT: ARBOX|OTHER: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Low Dose Bortezomib on Bone Formation in Smoldering Myeloma Patients
Status: TERMINATED
Conditions: Cancer|Myeloma|Multiple Myeloma
Interventions: DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Safety and Effectiveness of an IOL With a Virtual Aperture Optic
Status: NOT_YET_RECRUITING
Conditions: Intraocular Lens|Cataract|Presbyopia
Interventions: PROCEDURE: cataract surgery|DEVICE: implantation of device IOL FG-80030.1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Soy Protein Supplement in Preventing Prostate Cancer in Patients With Elevated Prostate-Specific Antigen Levels
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: soy protein isolate|DIETARY_SUPPLEMENT: casein proteins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Palbociclib Pharmacokinetics Study In Postmenopausal Chinese Women With ER (+), HER2 (-) Advanced Breast Cancer
Status: UNKNOWN
Conditions: Advanced Breast Cancer
Interventions: DRUG: Palbociclib|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: |Masking: NONE|Primary Purpose: OTHER
Clinical trial: Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock?
Status: RECRUITING
Conditions: Acute Kidney Injury|Septic Shock|Nicotinamide|Mortality
Interventions: DRUG: Nicotinamide treatment|DRUG: placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radial Extracorporeal Shock Wave Therapy Versus High Power Pain Threshold Ultrasound Therapy in Supraspinatus Tendinitis
Status: UNKNOWN
Conditions: Supraspinatus Tendinitis
Interventions: OTHER: control group|DEVICE: extracorporeal shock wave therapy|DEVICE: high power pain threshold ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Topical Pentoxifylline and Tocopherol in Treatment and Prevention of Medically-related Osteonecrosis of the Jaws
Status: COMPLETED
Conditions: Medically Related Osteonecrosis of the Jaws
Interventions: DRUG: Tocopherol and pentoxifilline topical gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Unrelated Umbilical Cord Blood Following HLA-haploidentical Hematopoietic Stem Cell Transplantation in Patients With β-thalassemia Major
Status: UNKNOWN
Conditions: Thalassemia Major
Interventions: GENETIC: unrelated CB following haplo-identical hematopoietic stem cells transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing of Microcoil Localization and Hook Wire Localization for Resectable Pulmonary Small Nodules
Status: UNKNOWN
Conditions: Thoracic Surgery
Interventions: PROCEDURE: microcoil localization|PROCEDURE: hookwire localization
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Tolerance and Experimental Hyperalgesia Study of Oral NGX426 in Healthy Male Voluneteers
Status: COMPLETED
Conditions: Healthy|Hyperalgesia
Interventions: DRUG: Placebo|DRUG: Oral NGX426 (Powder in solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Diagnostic Performance of Spectra IMDx System for Detection of Gastric Cancer and Precancerous Lesions
Status: UNKNOWN
Conditions: Gastric Cancer|Gastric Precancerous Lesion
Interventions: DEVICE: Spectra IMDx system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nivolumab With Ipilimumab Combined With TGFβ-15 Peptide Vaccine and Radiotherapy for Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab|RADIATION: SBRT|BIOLOGICAL: TGFβ-B-15 peptide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Reslizumab in Chronic Rhinosinusitis
Status: UNKNOWN
Conditions: Sinusitis
Interventions: DRUG: Reslizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Cerebral Oximetry In Reducing Delirium After Complex Cardiac Surgery
Status: COMPLETED
Conditions: Cardiac Disease
Interventions: DEVICE: Cerebral oximetry monitor (The INVOS® Cerebral/Somatic Oximeter)|OTHER: An alarm threshold at 75% of the baseline rSO2 value
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cannabis and Cancer, an Online Training for Oncology Nurses
Status: ACTIVE_NOT_RECRUITING
Conditions: Cannabis Use|Cannabis Use, Unspecified|Nurse's Role|Oncology Pain|Symptoms and Signs
Interventions: OTHER: Cannabis & Cancer digital educational intervention|OTHER: Standard information regarding cannabis use in oncology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized, Open-label Trial of Long-acting Injectable Risperidone Versus Oral Antipsychotic Medication in Patients With Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 89Zr-girentuximab ) Dosimetry in CCRC Study - ZIR-DOSE
Status: COMPLETED
Conditions: Clear Cell Renal Carcinoma
Interventions: DIAGNOSTIC_TEST: 89Zr-Girentuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Explore the PK and PD of INV-202 in Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DRUG: INV-202|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Scintigraphic Assessment Following Klean-Prep® or Moviprep®
Status: COMPLETED
Conditions: Gastric Emptying|Healthy
Interventions: DRUG: Klean-Prep®|DRUG: Moviprep®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Bacterial ACE2 Receptors -Like Enzyme of B38-CAP Could be Promising Treatment for COVID-19 Infection- and Its Inflammatory Complications Better Than Recombinant Human ACE2
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Recombinant Bacterial ACE2 receptors -like enzyme of B38-CAP (rbACE2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study of a Modified Lumbar Puncture (LP) Procedure That Reduces Post-Lumbar Puncture Headaches (PLPH) in Patients
Status: RECRUITING
Conditions: Post-Lumbar Puncture Headache
Interventions: PROCEDURE: Modified Lumbar Puncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: R-CHOP Versus R-mini-CEOP in Elderly Patients(>65)With DLBCL
Status: COMPLETED
Conditions: Elderly Patients (>65 Years)|Diffuse Large B Cell Lymphoma (DLBCL)
Interventions: DRUG: Cyclophosphamide|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone|DRUG: Prednisone|DRUG: Epirubicin|DRUG: Vinblastine|DRUG: Rituximab|DRUG: G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peripheral Tissue Perfusion and Oxygenation in Areas at Risk of Press Ulcer (POTER-OIL)
Status: NOT_YET_RECRUITING
Conditions: Pressure Ulcer
Interventions: OTHER: MEPENTOL® AND FARMAOLIVA® IN HEALTHY WITH INTRASUBJECT CONTROL|OTHER: MEPENTOL® AND FARMAOLIVA® IN PATIENTS WITH INTRASUBJECT CONTROL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Investigation of Performance and Compatibility of the Baxter Dialyzer Xenium XPH 210 During On-line Hemodiafiltration
Status: COMPLETED
Conditions: End Stage Kidney Disease
Interventions: DEVICE: Dialyzer Baxter Xenium XPH 210
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ghrelin (OXE--103) for Acute Concussion Management
Status: COMPLETED
Conditions: Concussion, Brain|Traumatic Brain Injury
Interventions: DRUG: Ghrelin (OXE-103)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Effect of the Timing of a Meal on the Pharmacokinetics of Entinostat
Status: COMPLETED
Conditions: Volunteers|Healthy Volunteers|Human Volunteers|Normal Volunteers
Interventions: DRUG: Entinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Role of Endoscopic Third Ventriculostomy in Management of Malfunctioning Ventriculoperitoneal Shunt
Status: NOT_YET_RECRUITING
Conditions: Hydrocephalus|Shunt Malfunction
Interventions: DEVICE: Endoscopic third ventriculostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Transdermal Vitamin D Supplement Study
Status: RECRUITING
Conditions: Vitamin D Supplementation
Interventions: DIETARY_SUPPLEMENT: Vitamin D phosphate|DIETARY_SUPPLEMENT: Placebo transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Status in Inflammatory Bowel Disease
Status: UNKNOWN
Conditions: Vitamin D Deficiency|Inflammatory Bowel Diseases
Interventions: DIAGNOSTIC_TEST: serum total 25 hydroxycholecalciferol 25(OH) vitamin D|DIAGNOSTIC_TEST: complete blood count (CBC)|DIAGNOSTIC_TEST: serum calcium level|DIAGNOSTIC_TEST: erythrocyte sedimentation rate (ESR)|DIAGNOSTIC_TEST: C-reactive protein (CRP)|DIAGNOSTIC_TEST: serum creatinine|DIAGNOSTIC_TEST: serum albumin level|DIAGNOSTIC_TEST: seum alanine aminotransferase|DIAGNOSTIC_TEST: serum potassium level|DIAGNOSTIC_TEST: serum phosphurus level
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hypoglycemia and Autonomic Nervous System Function-B
Status: UNKNOWN
Conditions: Hypoglycemia|Healthy
Interventions: DRUG: Spironolactone|DRUG: Placebo|OTHER: Hypoglycemic Hyperinsulinemic Clamp|OTHER: Euglycemic Hyperinsulinemic Clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bidimensional Rectal-water Contrast-transvaginal Ultrasonography (2D-RWC-TVS) Versus 3D-RWC-TVS in the Diagnosis of Rectosigmoid Endometriosis
Status: UNKNOWN
Conditions: Endometriosis, Rectum|Endometriosis of Colon
Interventions: DIAGNOSTIC_TEST: Three-dimensional rectal water contrast transvaginal ultrasonography (3D-RWC-TVS)|DIAGNOSTIC_TEST: Two-dimensional rectal water contrast transvaginal ultrasonography (2D-RWC-TVS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Bag-Valve-Guedel Adaptor to Common Face Mask for the Ventilation of Bearded Men
Status: COMPLETED
Conditions: Pre-hospital Ventilation
Interventions: DEVICE: BVGA|DEVICE: Face Mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Girls In Recovery From Life Stress (GIRLS) Study
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder|PTSD
Interventions: BEHAVIORAL: Trauma Adaptive Recovery Group Education and Therapy|BEHAVIORAL: Enhanced Treatment As Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-dose vs. Standard-dose Cephalexin for Cellulitis
Status: COMPLETED
Conditions: Cellulitis
Interventions: DRUG: Cephalexin|DRUG: Cephalexin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Studies on the Glycemic Index After Intake of Different Sorts of Barley in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: 100% wheat|DIETARY_SUPPLEMENT: 50% nude barley and 50% wheat|DIETARY_SUPPLEMENT: 75% nude barley and 25% wheat|DIETARY_SUPPLEMENT: 50% gene-modified high-amylose barley and 50% wheat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CZECH-ICIT (CZECH Inflammatory Cardiomyopathy Immunosuppression Trial)
Status: UNKNOWN
Conditions: Inflammatory Cardiomyopathy
Interventions: DRUG: Combination of prednisone and azathioprine|DRUG: Combination of prednisone and azathioprine|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRONTO: Artemis in the Removal of Intraventricular Hemorrhage in the Hyper-Acute Phase
Status: TERMINATED
Conditions: Intracerebral Hemorrhage|Brain Hemorrhage|Intraventricular Hemorrhage
Interventions: DEVICE: Artemis Neuro Evacuation Device
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Integrated, Practice-oriented Electromechanical-assisted Gait Training in Subacute Stroke Patients
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: LYRA® gait trainer|DEVICE: Standard individual physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Calcium Sulfate Spacer in Open Tibia Fractures
Status: TERMINATED
Conditions: Open tíbia Fracture With Sub-segmental Bone Loss
Interventions: DRUG: Calcium Sulfate|DRUG: PMMA|OTHER: No treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Use of Anticonvulsants for Treatment of Patients With Alcohol Dependence and Post Traumatic Stress Disorder
Status: WITHDRAWN
Conditions: Alcohol Dependence|Post Traumatic Stress Disorder
Interventions: DRUG: Topiramate|DRUG: lamotrigine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Polymeric Versus Oligomeric Enteral Feeding on Tolerance and Nutritional Status in Paediatric Intensive Care
Status: RECRUITING
Conditions: Enteral Feeding Intolerance
Interventions: DIETARY_SUPPLEMENT: Oligomeric enteral feeding|DIETARY_SUPPLEMENT: Polymeric enteral feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Repeat Dose Administration of Long-Acting GSK1265744 and Long-Acting TMC278 Intramuscular and Subcutaneous Injections in Healthy Adult Subjects
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: GSK1265744 Oral|DRUG: GSK1265744 LAP 800mg intramuscular injection|DRUG: GSK1265744 LAP 200mg subcutaneous injection|DRUG: GSK1265744 LAP 200mg intramuscular injection|DRUG: GSK1265744 LAP 400mg intramuscular injection|DRUG: TMC278 LA 1200mg intramuscular injection|DRUG: TMC278 LA 600mg intramuscular injection|DRUG: GSK1265744 LAP 800mg intramuscular injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Knowledge on Vaccine Take-up in Adamawa State, Northeastern Nigeria
Status: COMPLETED
Conditions: Immunization; Infection|Educational Problems|Information Seeking Behavior
Interventions: BEHAVIORAL: Information Provision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Improving Vaccination in Older Adults by Inducing Autophagy With Spermidine
Status: COMPLETED
Conditions: COVID-19|Vaccine Reaction
Interventions: DIETARY_SUPPLEMENT: Spermidine or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Thai Dance With Twenty-five Squares in Elderly With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: OTHER: Thai dance with twenty-five squares (TDT)|OTHER: Control (CON)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lidocaine Infusion On Hysteroscopic Media Versus Oral Diclofinac For Pain Relief During Outpatient Hysteroscopy
Status: UNKNOWN
Conditions: Nulliparity
Interventions: DRUG: Lidocaine Hydrochloride|DRUG: Diclofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Cardiac Safety Study of Tivozanib to Evaluate the Electrocardiogram and Pharmacokinetic-Electrocardiogram Dynamics in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: tivozanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Impact of SGLT2 on Glucosuria in HNF1A-MODY
Status: COMPLETED
Conditions: Maturity-Onset Diabetes of the Young, Type 3|Type 2 Diabetes
Interventions: OTHER: Hyperglycaemic clamp|DRUG: Placebo|DRUG: Empagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Drug-drug-interaction Study of Candesartan, Amlodipine and Atorvastatin
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Candesartan, Amlodipine, Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pedometer-Based Walking Intervention on Physical Activity Among Hemodialysis Patients
Status: RECRUITING
Conditions: Physical Inactivity|Fatigue
Interventions: BEHAVIORAL: traditional pedometer based walking intervention|BEHAVIORAL: gamified pedometer based walking intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Study to Assess the Pharmacokinetics of Pimicotinib in Subjects With Mild and Moderate Hepatic Impairment Relative to Subjects With Normal Hepatic Function
Status: NOT_YET_RECRUITING
Conditions: Pharmacokinetics
Interventions: DRUG: Pimicotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN9035 in Healthy Adult Volunteers and Mildly Hypertensive Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: REGN9035|DRUG: REGN5381|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Pretreatment of Lignocaine Versus Midazolam in Prevention of Etomidate Induced Myoclonus.
Status: COMPLETED
Conditions: Myoclonic Jerk
Interventions: DRUG: lignocaine|DRUG: Midazolam 1 milligram Prefilled Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Etonogestrel + 17β-Estradiol Vaginal Ring and Levonorgestrel-Ethinyl Estradiol Combined Oral Contraceptive in Adult Women at Risk for Pregnancy (MK-8342B-062)
Status: TERMINATED
Conditions: Contraception
Interventions: DRUG: ENG-E2 125 μg/300 μg vaginal ring|DRUG: LNG-EE 150 μg/30 μg COC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparative Assessment of Compumedics Somfit Sleep Monitoring Device
Status: COMPLETED
Conditions: Sleep-Disordered Breathing
Interventions: DEVICE: Compumedics Somfit HSAT device, WatchPAT HSAT device, Compumedics Grael /E-series PSG system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessment of the Effect of Periodontal Disease Prediction System on Oral Hygiene Motivation
Status: COMPLETED
Conditions: Motivational Interviewing|Computer-Aided Design|Periodontal Diseases
Interventions: PROCEDURE: scaling root planing|BEHAVIORAL: Three-Dimensional Animation (video1-2)|BEHAVIORAL: Three-Dimensional Animation (video 3)|BEHAVIORAL: Periodontal Disease Prediction (PDP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Caffeine and LISA Compared to Caffeine and CPAP in Preterm Infants
Status: ACTIVE_NOT_RECRUITING
Conditions: Premature Lungs|Respiratory Distress Syndrome|Surfactant Deficiency Syndrome Neonatal
Interventions: PROCEDURE: Less Invasive Surfactant Administration LISA|PROCEDURE: Continuous Positive Airway Pressure CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study in Healthy Men to Find the Best Formulation of BI 685509 and to Test How it is Taken up in the Body
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: R1: Reference Product X|DRUG: T1: Test Product M|DRUG: T2: Test Product N|DRUG: T3: Test Product O|DRUG: T4: Test Product O|DRUG: R2: Reference Product Y|DRUG: T5: Test Product P|DRUG: T6: Test Product P|DRUG: T7: Test Product Q|DRUG: R3: Reference Product Z|DRUG: T8: Test Product S|DRUG: T9: Test Product S|DRUG: T10: Test Product U
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radioembolization for HCC Patients With Personalized Yttrium-90 Dosimetry for Curative Intent (RAPY90D)
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage III Hepatocellular Carcinoma AJCC v8|Stage IIIA Hepatocellular Carcinoma AJCC v8|Stage IIIB Hepatocellular Carcinoma AJCC v8|Stage IV Hepatocellular Carcinoma AJCC v8|Stage IVA Hepatocellular Carcinoma AJCC v8|Stage IVB Hepatocellular Carcinoma AJCC v8|Unresectable Hepatocellular Carcinoma
Interventions: PROCEDURE: Computed Tomography|OTHER: Hepatobiliary Iminodiacetic Acid Scan|PROCEDURE: Single Photon Emission Computed Tomography|RADIATION: Yttrium Y 90 Glass Microspheres|PROCEDURE: Yttrium-90 Microsphere Radioembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: N-acetylcysteine for Primary Sjögren's Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Sjögren Syndrome|Sicca Syndrome
Interventions: DRUG: N-acetylcysteine syrup|DRUG: Placebo syrup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rifaximin as a Prophylaxis of Spontaneous Bacterial Peritonitis in Comparison With Ciprofloxacin
Status: COMPLETED
Conditions: Spontaneous Bacterial Peritonitis
Interventions: DRUG: Rifaximin 550Mg Tab|DRUG: Ciprofloxacin 750 MG|DIAGNOSTIC_TEST: ascitic fluid sample
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Extension of Phase II Therapeutic Trial With a Humanized Non-Mitogenic CD3 (ChAgly CD3) Monoclonal Antibody in Recently Diagnosed Type 1 Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: ChAgly CD3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial on Conservative Treatment for Infants' Hirschsprung Disease
Status: COMPLETED
Conditions: Hirschsprung Disease
Interventions: PROCEDURE: surgery treatment|BEHAVIORAL: anal dilation|BEHAVIORAL: colonic lavage|DRUG: oral probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bisoprolol in DMD Early Cardiomyopathy
Status: UNKNOWN
Conditions: Duchenne Muscular Dystrophy|Cardiomyopathy, Dilated
Interventions: DRUG: Bisoprolol Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nonavalent HPV Vaccine in the Treatment of Difficult-to-treat Palmo-plantar Warts
Status: RECRUITING
Conditions: Palmar or Plantar Warts
Interventions: BIOLOGICAL: Vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Deferasirox in Treating Patients With Iron Overload After Undergoing a Donor Stem Cell Transplant
Status: TERMINATED
Conditions: Breast Cancer|Iron Overload|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Neuroblastoma|Ovarian Cancer
Interventions: DRUG: deferasirox
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prexasertib in Combination With MEC in Relapsed/Refractory AML and High Risk MDS - a Phase I Trial
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: Prexasertib|DRUG: Mitoxantrone|DRUG: Etoposide|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose Study to Assess Safety and Pharmacokinetics of Hemay005 In Healthy Subjects
Status: UNKNOWN
Conditions: Psoriasis
Interventions: DRUG: Hemay005|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Training and Counseling Based on Mercer Maternal Role Theory on Maternal Attachment and Maternal Function
Status: COMPLETED
Conditions: Maternal-Fetal Relations|Maternal Behavior
Interventions: BEHAVIORAL: education and counseling based on maternal role theory
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Trial of Low Intensity Shockwaves Therapy for Erectile Dysfunction Post-Radical Prostatectomy
Status: WITHDRAWN
Conditions: Erectile Dysfunction
Interventions: DEVICE: Shockwave Therapy|OTHER: SHAM shockwave therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: EBA-175 RII-NG Malaria Vaccine Administered Intramuscularly in Semi-immune Adults
Status: COMPLETED
Conditions: Plasmodium Falciparum Malaria
Interventions: DRUG: Placebo|BIOLOGICAL: EBA-175 RII-NG Malaria Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Kinesiophobia on Physical Activity, Balance and Falling in Parkinson's Disease Patients
Status: COMPLETED
Conditions: Parkinson Disease|Kinesiophobia|Physical Activity|Balance|Falling
Interventions: OTHER: Tampa Kinesiophobia Scale, Berg-Balance Test, International Physical Activity Questionnaire-Short Form, Falls Efficacy Scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p