pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy Study of Kinto Care Coaching for Dementia Family Caregivers
Status: COMPLETED
Conditions: Dementia|Alzheimer Disease|Lewy Body Disease|Vascular Dementia|Frontotemporal Dementia|Mixed Dementia
Interventions: BEHAVIORAL: Kinto Care Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Use of High Fidelity Simulation in Cardiac-specific Anesthesia Scenarios for Resident Education and Assessment
Status: COMPLETED
Conditions: Resident Education and Assessment of Difficult and High Acuity Scenarios That Focus on Cardiac Anesthesia
Interventions: OTHER: Teaching,education,feedback and practice sessions to help improve as needed
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Kayak Ergometer Training in Individuals With Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: OTHER: kAYAK ERGOMETER GROUP|OTHER: CONTROL GROUP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aerosol Inhalation Treatment for Dyspnea
Status: COMPLETED
Conditions: Healthy|Dyspnea
Interventions: DRUG: Furosemide|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Early Stage Follicular LymphOma and RadioTherapy PLUS Anti-CD20 Antibody
Status: RECRUITING
Conditions: Early Stage Follicular Lymphoma WHO Grade 1/2 or 3a
Interventions: RADIATION: Standard|RADIATION: Experimental|DRUG: Standard|DRUG: Experimental
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Cisplatin, Cetuximab and Temsirolimus in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
Status: TERMINATED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: temsirolimus|DRUG: cisplatin|DRUG: cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Effects of Temperature Controlled Laminar Airflow (TLA)
Status: COMPLETED
Conditions: Asthma|Perennial Allergy
Interventions: DEVICE: Temperature controlled Laminar Airflow (Protexo)|DEVICE: Placebo TLA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing The Tolerability Of Three Excipient Formulations Administered Subcutaneously To Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Formulation buffers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: ALL SCTped FORUM - Pharmacogenomic Study (add-on Study)
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia
Interventions: GENETIC: Pharmacogenomics|OTHER: Busulfan plasma level measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Comparison of Capsules and Oral Spray Solution as Methods of Delivering Vitamin D3 and Raising Status
Status: COMPLETED
Conditions: Vitamin D Concentration|Vitamin D Status
Interventions: DIETARY_SUPPLEMENT: 3000IU(75μg) vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Clinical Trial to Evaluate the Tolerability and Pharmacokinetics of CKD-386
Status: COMPLETED
Conditions: Hypertension and Dyslipidemia
Interventions: DRUG: CKD-386|DRUG: D012, D326, D337
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Neurodevelopmental ouTcomes After Prenatal Cannabinoid in uTero Exposure
Status: NOT_YET_RECRUITING
Conditions: Developmental Delay
Interventions: BEHAVIORAL: Play and Learn Strategies (PALS) Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Tezepelumab in Participants With Severe Chronic Rhinosinusitis With Nasal Polyposis
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Rhinosinusitis With Nasal Polyps
Interventions: BIOLOGICAL: Experimental: Tezepelumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Memory Encoding Strategies for People With Mild Cognitive Impairments
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Mild Dementia
Interventions: OTHER: Behavioral: perceptual-based memory encoding training|OTHER: Behavioral: semantic-based memory encoding training|OTHER: Behavioral: Cognitive stimulation group (control group)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pazopanib Hydrochloride or a Placebo in Treating Patients With Non-Small Cell Lung Cancer Who Have Received First-Line Chemotherapy
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DRUG: pazopanib hydrochloride|OTHER: laboratory biomarker analysis|OTHER: pharmacogenomic studies|OTHER: pharmacological study|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Hereditary Ataxia
Status: UNKNOWN
Conditions: Hereditary Ataxia
Interventions: BIOLOGICAL: human umbilical cord mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Biological Therapy In Treating Patients With Kidney Cancer That Is Metastatic or Cannot Be Removed Surgically
Status: UNKNOWN
Conditions: Kidney Cancer
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: recombinant interferon alfa|DRUG: fluorouracil|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of Lurbinectedin (PM01183) in Combination With Capecitabine in Patients With Metastatic Breast Cancer (MBC), Pancreatic Cancer (PC) or Metastatic Colorectal Cancer (CRC).
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Pancreatic Cancer|Metastatic Colorectal Cancer
Interventions: DRUG: lurbinectedin (PM01183)|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of AR08 for the Treatment of Vasomotor Symptoms (VMS)
Status: TERMINATED
Conditions: Vasomotor Symptoms (VMS)
Interventions: DRUG: AR08|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Levels of Circulating Tumor DNA as a Predictive Marker for Early Switch in Treatment for Patients With Metastatic (Stage IV) Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|ER-positive Breast Cancer|HER2-negative Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: AI+CDK4/6i|DRUG: SERD+CDK4/6i|DRUG: mTOR inhibitor + AI|DRUG: mTOR inhibitor + SERD|DRUG: mTOR inhibitor + Selective estrogen receptor modulator|DRUG: PI3K inhibitor + SERD|DRUG: PI3K inhibitor + AI|DRUG: Chemotherapy|DRUG: Oral SERD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of High Dose Cyclophosphamide in Patients With Severe Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria
Status: COMPLETED
Conditions: Aplastic Anemia|Paroxysmal Hemoglobinuria, Nocturnal
Interventions: DRUG: cyclophosphamide|DRUG: filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: App-technology to Improve the Level of Physical Activity After Bariatric Surgery
Status: COMPLETED
Conditions: Obesity|Bariatric Surgery|Exercise|Quality of Life|Eating Behavior|Body Fat Distribution|Body Weight Changes
Interventions: BEHAVIORAL: App-technology to increase physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Venetoclax Basket Trial for High Risk Hematologic Malignancies
Status: RECRUITING
Conditions: Myelodysplastic Syndromes, de Novo|Myelodysplastic Syndromes, Secondary|Myelodysplastic Syndromes, Previously Treated|Treatment-Related Acute Myeloid Leukemia|Therapy-Related Myelodysplastic Syndrome|Acute Lymphoblastic Leukemia, in Relapse|Acute Lymphoblastic Leukemia With Failed Remission|Lymphoblastic Lymphoma, in Relapse|Lymphoblastic Lymphoma, Refractory|Acute Leukemia of Ambiguous Lineage in Relapse|Acute Leukemia of Ambiguous Lineage
Interventions: DRUG: Venetoclax|DRUG: Azacitidine|DRUG: Cytarabine|DRUG: Methotrexate|DRUG: Hydrocortisone|DRUG: Leucovorin|DRUG: Dexamethasone|DRUG: Vincristine|DRUG: Doxorubicin|DRUG: Dexrazoxane|DRUG: Calaspargase Pegol|DRUG: Erwinia asparaginase
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sunitinib Tumor Levels in Patients Not on Enzyme-Inducing Anti-Epileptic Drugs Undergoing Debulking Surgery for Recurrent Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma|Brain Tumor
Interventions: DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Modified Stylet Angulation on the Intubation With GlideScope®
Status: COMPLETED
Conditions: Cholecystitis|Stomach Cancer
Interventions: PROCEDURE: Glidescope guided intubation|DEVICE: GlideScope®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Metastatic Cancer
Status: COMPLETED
Conditions: Melanoma (Skin)|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: incomplete Freund's adjuvant|BIOLOGICAL: telomerase: 540-548 peptide vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of SARS CoV-2 Infection and Potential Transmission in Individuals Immunized With Moderna COVID-19 Vaccine
Status: COMPLETED
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: Moderna COVID-19 Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Interlock Nailing Versus Dynamic Compression Plating in Transverse Fractures of Tibia
Status: COMPLETED
Conditions: Transverse Fracture of Shaft of Tibia
Interventions: DEVICE: DCP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: POST-CABGDM: Empagliflozin in Perioperative CABG
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Coronary Artery Disease|Coronary Artery Bypass Surgery|Acute Kidney Injury
Interventions: DRUG: Empagliflozin 25 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating Telerehabilitation as an add-on to Face-to-face Speech and Language Therapy in Post-stroke Aphasia.
Status: COMPLETED
Conditions: Aphasia|Chronic Stroke|Post Stroke Seizure
Interventions: DEVICE: teleSLT|DEVICE: teleCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Glidesheath Slender to Reduce Radial Artery Occlusion and Vascular Access Site Complications Following Transradial Coronary Angiography
Status: COMPLETED
Conditions: Embolism and Thrombosis of the Radial Artery|Coronary Heart Disease
Interventions: DEVICE: Glidesheath Slender|DEVICE: standard 6- French radial sheath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Liraglutide 3 mg for Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis|Obesity
Interventions: DRUG: Liraglutide 3 mg (Saxenda)|DRUG: Liraglutide 3 mg placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Amiodarone to Prevent Atrial Fibrillation in Lung Transplant Patients
Status: COMPLETED
Conditions: Atrial Fibrillation|Lung Transplant; Complications
Interventions: DRUG: Amiodarone with CoSeal|DEVICE: CO2 driver
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ELI-002 7P in Subjects With KRAS/NRAS Mutated Solid Tumors
Status: RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma|Colorectal Cancer|KRAS G12D|KRAS G12R|KRAS G12V|KRAS G12A|KRAS G12C|KRAS G12S|KRAS G13D|NRAS G12D|NRAS G12R|NRAS G12V|NRAS G12C|NRAS G12S
Interventions: DRUG: ELI-002 7P
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Administration Schedules of G-CSF (Filgrastim) for Primary Prophylaxis of Febrile Neutropenia
Status: COMPLETED
Conditions: Early Stage Breast Cancer
Interventions: DRUG: Neupogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperglycemia and Effects of Daily 100 mg Versus 200 mg of Hydrocortisone Therapy in Patients With Septic Shock
Status: COMPLETED
Conditions: Hyperglycemia
Interventions: DRUG: Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Psycho-Educational Cognition Intervention in Patients With Blood and Lymph Cancer
Status: WITHDRAWN
Conditions: Hematopoietic and Lymphoid Cell Neoplasm
Interventions: OTHER: Educational Intervention|OTHER: Quality-of-Life Assessment|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Use of Barbed Sutures in Total Hip Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis, Hip
Interventions: DEVICE: Interrupted Knotted Sutures|DEVICE: STRATAFIX Symmetric PDS PLUS Knotless Tissue Control Devices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety and Efficacy of PA21 (Velphoro®) and Calcium Acetate (Phoslyra®) in Paediatric and Adolescent Chronic Kidney Disease (CKD) Patients With Hyperphosphataemia
Status: TERMINATED
Conditions: Hyperphosphatemia
Interventions: DRUG: PA21 (Velphoro®)|DRUG: Calcium Acetate (Phoslyra®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vagus Nerve Stimulation: Integration of Behavior and Cardiac Modulation
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: exhalatory-gated transcutaneous vagus nerve stimulation (e-RAVANS)|DEVICE: Inhalatory-gated transcutaneous vagus nerve stimulation (i-RAVANS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant Sorafenib Therapy Prior to Laser Ablation for Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Sorafenib|PROCEDURE: laser ablation (LA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Endostatin in Improving Radiation Pneumonia and Fibrosis
Status: COMPLETED
Conditions: Radiation Pneumonitis|Endostatin
Interventions: DRUG: Endostar|DRUG: standard SRILI treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of His Bundle Pacing Validated by Extracardiac Vagal Nerve Stimulation
Status: RECRUITING
Conditions: Permanent His Bundle Pacing|Permanent Left Bundle Branch Pacing
Interventions: DIAGNOSTIC_TEST: extracardiac vagal nerve stimulation (ECANS) + EPS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of suPAR Biomarker in Blood Samples of Breast Cancer Patients During and Post Doxorubicin Chemotherapy: Causative vs. Predictor
Status: COMPLETED
Conditions: Doxorubicin Adverse Reaction|Cardiomyopathies, Secondary|Breast Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: mTORC1/mTORC2 Kinase Inhibitor AZD2014 in Previously Treated Glioblastoma Multiforme
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: AZD2014
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate if Adding Lactulose to Vitamin D and Calcium Has an Effect on the Preservation of Bone in Postmenopausal Women
Status: COMPLETED
Conditions: Osteopenia
Interventions: DRUG: Lactulose, Vitamin D, Calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: Depakote ER Plus an Atypical Antipsychotic Vs. an Atypical Antipsychotic Alone in the Treatment of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Divalproex Sodium Extended-Release Tablets|DRUG: Olanzapine|DRUG: Risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: LGX818 in Combination With Agents (MEK162; BKM120; LEE011; BGJ398; INC280) in Advanced BRAF Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: LGX818
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Broad-spectrum Rapid Antidote: Varespladib Oral for Snakebite
Status: COMPLETED
Conditions: Snakebites|Envenoming|Envenoming, Snake|Envenomation, Snake
Interventions: DRUG: Varespladib Methyl|DRUG: Placebo|DRUG: Standard of care (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Effects of Estrogen in Healthy Postmenopausal Women
Status: COMPLETED
Conditions: Postmenopausal Symptoms
Interventions: DRUG: Comparator: Estrace 0.5 mg|DRUG: Comparator: Estrace 2 mg|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Lapatinib and Tamoxifen in Treating Patients With Advanced or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: lapatinib ditosylate|DRUG: tamoxifen citrate|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effect of siSPARC Microneedle Patch Versus siSPARC+siLR4A Microneedle Patch on Post-surgical Scars
Status: RECRUITING
Conditions: Keloid|Wound Heal|Wound
Interventions: DRUG: siSPARC + siLR4A microneedle patches|DRUG: siSPARC microneedle patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Blackcurrant and Citrus Polyphenol Extracts on Postprandial Glycaemia
Status: COMPLETED
Conditions: Postprandial Period
Interventions: DIETARY_SUPPLEMENT: Blackcurrant extract (low dose)|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Citrus extract (low dose)|DIETARY_SUPPLEMENT: Blackcurrant extract (high dose)|DIETARY_SUPPLEMENT: Blackcurrant and citrus extracts (low dose / low dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Treatment of Disitamab Vedotin in Patients With Locally Advanced or Metastatic Pancreatic Cancer
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Disitamab Vedotin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Tucatinib (MK-7119) in Chinese Participants With Cancer (MK-7119-002)
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic HER2+ Advanced Breast Cancer|Breast Neoplasms|Gastric or Gastroesophageal Junction Adenocarcinoma (GEC)|Colorectal Cancer
Interventions: DRUG: Tucatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aldosterone, the Mineralocorticoid Receptor, and Cardiovascular Disease in Obesity
Status: RECRUITING
Conditions: Metabolic Syndrome|Hypertension|Overweight and Obesity
Interventions: DRUG: Eplerenone|DRUG: Chlorthalidone with potassium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans
Status: NOT_YET_RECRUITING
Conditions: Appetitive Behavior|Obesity
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)|DEVICE: Sham repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of ES002023 (Anti-CD39 Antibody) in Patients With Locally Advanced or Metastatic Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: Part 1 ES002023|DRUG: Part 2 ES002023
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Montage of HTDCS in Psycho-cognitive Functions in FM
Status: UNKNOWN
Conditions: Fibromyalgia
Interventions: DEVICE: Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Randomized, Placebo-controlled, Double-blind Study to Assess the Efficacy of Bacillus Coagulans Unique IS2 on Improving Bowel Movement Characteristics, Gastrointestinal-related Symptoms and Quality of Life in Healthy Adult Participants
Status: COMPLETED
Conditions: Stool Frequency
Interventions: OTHER: Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cardio-pulmonary and Analgesic Effects of Pre-peritoneal VS Epidural Infusion of L-bupivacaine on Abd. Cancer Patients
Status: COMPLETED
Conditions: Abdominal Cancer
Interventions: PROCEDURE: levo-bupivacaine infusion via Thoracic epidural catheter|PROCEDURE: levo-bupivacaine infusion via preperitoneal catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Standard of Care (SOC) With or Without CTS-1027 in Hepatitis C (HCV) Null-Responders
Status: TERMINATED
Conditions: Hepatitis C
Interventions: DRUG: CTS-1027|DRUG: pegylated interferon|DRUG: Ribavirin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of 10 mg Monacolins on Vascular Health: a Clinical Trial
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DIETARY_SUPPLEMENT: Red yeast rice|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Monoclonal Antibody Therapy and Colony- Stimulating Factor in Treating Patients With Metastatic Colorectal Cancer
Status: WITHDRAWN
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: edrecolomab|BIOLOGICAL: sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Exploring the Effect of Crizanlizumab on Kidney Function in Patients With Chronic Kidney Disease Caused by Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease (SCD)
Interventions: DRUG: Crizanlizuamb|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Food on the Bioavailability of Telmisartan/Amlodipine Fixed Dose Combination in Healthy Japanese Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Telmisartan/Amlodipine low dose|DRUG: Telmisartan/Amlodipine high dose|OTHER: Japanese meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-center:The Small (14F) Percutaneous Catheter vs. Large (28-40F) Open Chest Tube for Traumatic Hemothorax (P-CAT)
Status: COMPLETED
Conditions: The Efficacy of Percutaneous Catheter vs. Open Chest Tube|Traumatic Hemothorax
Interventions: DEVICE: Percutaneous catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Autonomic Nerve Modulation (ANM) in Subjects With Moderate Plaque Psoriasis
Status: UNKNOWN
Conditions: Plaque Psoriasis
Interventions: DEVICE: Autonomic Nerve Modulation - Active|DEVICE: Autonomic Nerve Modulation - Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Sex-matched vs. Sex-mismatched Red Blood Cell Transfusion
Status: COMPLETED
Conditions: Blood Transfusion
Interventions: BIOLOGICAL: Red blood cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nervus Cutaneous Femoris Lateralis-Blockade on Moderate Pain Responders After Total Hip Arthroplasty
Status: COMPLETED
Conditions: Pain, Postoperative|Ropivacaine|Therapeutic Use|Arthroplasty, Replacement, Hip
Interventions: DRUG: Ropivacaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety of Four Posaconazole Regimens With Placebo and Terbinafine in the Treatment of Toenail Onychomycosis (Study P05082AM2)(COMPLETED)
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: SCH 56592|DRUG: SCH 56592|DRUG: SCH 56592|DRUG: SCH 56592|DRUG: Terbinafine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Impact of Training on Outcome Measures in Subjects With Painful Diabetic Neuropathy
Status: UNKNOWN
Conditions: Diabetes Mellitus|Painful Distal Symmetric Sensorimotor Polyneuropathy
Interventions: DRUG: Pregabalin|DRUG: placebo|BEHAVIORAL: Training Type A|BEHAVIORAL: Training Type B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of LipiFlow in Patients Affected by Meibomian Gland Dysfunction in Reducing Post-cataract Surgery Dry Eye
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction|Cataract|Surgery--Complications|Dry Eye|Blepharitis
Interventions: DEVICE: LipiFlow Thermal pulsation system|PROCEDURE: Eyelid warm compresses plus massages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Nonintubated Versus Intubated General Anesthesia on Recovery After Thoracoscopic Lung Resection
Status: UNKNOWN
Conditions: Lung Neoplasms
Interventions: DRUG: propofol, bupivacaine|DRUG: sevoflurane, rocuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Percussive Ventilation Breathhold to Improve Lung Stereotactic Ablative Radiotherapy
Status: RECRUITING
Conditions: Lung Cancer
Interventions: OTHER: Percussive Ventilation Breathhold SABR (PVB-SABR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Developing Text-based Support for Parents of Adolescents After an Emergency Department Visit
Status: COMPLETED
Conditions: Suicide
Interventions: BEHAVIORAL: A-F texting component|BEHAVIORAL: P-F texting component
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Whole-Body Electromyostimulation and Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Whole-Body Electromyostimulation|OTHER: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Hypoxia and Inflammation on Citrulline Synthesis by Ornithine Transcarbamylase in Human Enterocytes
Status: UNKNOWN
Conditions: Hypoxia|Inflammation|Chronic Obstructive Pulmonary Disease
Interventions: PROCEDURE: duodenal biopsy during gastroduodenal endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prophylactic DLI for the Prevention of Relapse Post HSCT in Patients With High Risk Myeloid Malignancy
Status: UNKNOWN
Conditions: Myelodysplastic Syndromes|Leukemia, Myeloid, Acute
Interventions: OTHER: DLI will be administered to all patients at Month 4 (+/- 20 days) after stem cell transplant regardless of peripheral blood CD3 chimerism (including if they have full donor chimerism)|OTHER: DLI will be administered from Month 6 (+/- 20 days) after stem cell transplant according to institutional practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intratumoral Tilsotolimod, a TLR-9 Agonist, Together With Intratumoral Ipilimumab and Intravenous Nivolumab in Patients With Advanced Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Cancer
Interventions: DRUG: Ipilimumab|DRUG: Nivolumab|DRUG: Tilsotolimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Fetoscopic Surgery Protocols
Status: WITHDRAWN
Conditions: Minimally Invasive Fetoscopic Procedures
Interventions: DRUG: Remifentanil-dexmedetomidine|DRUG: Dexmedetomidine-fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy Study of Oral Zabofloxacin in Community Acquired Pneumonia
Status: TERMINATED
Conditions: Community Acquired Pneumonia
Interventions: DRUG: Zabofloxacin|DRUG: Levofloxacin 500mg|DRUG: Zabofloxacin 400mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability, Transdermally Administered EE and GSD, 3 Applications Sites
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Gestodene/EE Patch (BAY86-5016)|DRUG: Gestodene/EE Patch (BAY86-5016)|DRUG: Gestodene/EE Patch (BAY86-5016)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid Free Anesthesia for Laparoscopic Cholecystectomy
Status: RECRUITING
Conditions: Analgesia
Interventions: PROCEDURE: Erector Spinae Block|DRUG: Opioid Analgesic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility of Algisyl-LVR™ as a Method of Left Ventricular Restoration in Patients With DCM Undergoing Open-heart Surgery
Status: COMPLETED
Conditions: Dilated Cardiomyopathy
Interventions: DEVICE: Algisyl-LVR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Treatment With BTL-899 and HPM-6000UF Devices II
Status: COMPLETED
Conditions: Muscle Weakness
Interventions: DEVICE: BTL-899|DEVICE: HPM-6000UF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HU007 in Patients With Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: HU007|DRUG: Restasis|DRUG: Moisview Eye drop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anemia in Patients With a Non-Myeloid Malignancy
Status: COMPLETED
Conditions: Neoplasms|Anemia
Interventions: DRUG: Darbepoetin alfa|DRUG: rHuEPO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Pulpal Blood Flow Between Conventional and Self-ligating Fixed Orthodontic Brackets During Leveling and Alignment Stage
Status: COMPLETED
Conditions: Orthodontic Appliances
Interventions: OTHER: A Pre-adjusted edgewise brackets: 3M Gemini Unitek, 0.022" Roth prescription brackets|OTHER: Self- ligating brackets: Unitek™ Gemini SL Self-Ligating Brackets, 0.022" Roth prescription brackets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fludarabine/Rituximab Combined With Escalating Doses of Lenalidomide in Untreated CLL
Status: COMPLETED
Conditions: CLL|Chronic Lymphocytic Leukemia
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heart Rate Controller in Computed Tomography Coronary Angiography
Status: UNKNOWN
Conditions: Heart Rate|Coronary Computed Tomography Angiography
Interventions: DRUG: Metoprolol tartrate|DRUG: Ivabradine|DRUG: Diltiazem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of STRO-002, an Anti-Folate Receptor Alpha Antibody Drug Conjugate, in Combination With Bevacizumab in Epithelial Ovarian Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer|Ovarian Carcinoma|Ovary Cancer|Fallopian Tube Cancer|Primary Peritoneal Carcinoma
Interventions: DRUG: STRO-002|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Potential Development of Photoallergic Skin Reaction After Use of MC2-01 Cream
Status: COMPLETED
Conditions: Photoallergy
Interventions: DRUG: Induction: Application of MC2-01 Cream, irradiation|DRUG: Induction: Application of MC2-01 Cream, no irradiation|DRUG: Induction: Applications of MC2-01 vehicle, irradiation|DRUG: Induction: Applications of MC2-01 vehicle, no irradiation|DRUG: Challenge: Application of MC2-01 Cream, irradiation|DRUG: Challenge: Application of MC2-01 Cream, no irradiation|DRUG: Challenge: Applications of MC2-01 vehicle, irradiation|DRUG: Challenge: Applications of MC2-01 vehicle, no irradiation|DRUG: Challenge: Control, irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of GSK1363089 (Formerly XL880) in Adults With Squamous Cell Cancer of the Head and Neck
Status: COMPLETED
Conditions: Neoplasms, Head and Neck
Interventions: DRUG: GSK1363089 (foretinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Group Alcohol Interventions for College Men
Status: COMPLETED
Conditions: Alcohol Drinking|Sexual Behavior
Interventions: BEHAVIORAL: BASICS|BEHAVIORAL: Integrated BASICS|BEHAVIORAL: Relaxation|BEHAVIORAL: Integrated Bystander
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Tolerability of CDX-6114 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CDX-6114|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of BMS-626529 in Healthy Subjects From Prototype Low Dose Extended Release Formulations (Part 1) and Prototype Extended Release Multi-particulate Formulations (Part 2) of BMS-663068 Relative to 600 mg Extended Release Tablet
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: BMS-663068
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Shared Decision-making on Medical Tests and Care Cascades
Status: COMPLETED
Conditions: Health Knowledge, Attitudes, Practice|Health Care Utilization
Interventions: BEHAVIORAL: Patient education materials|BEHAVIORAL: Physician peer-comparison email|BEHAVIORAL: Physician education materials|BEHAVIORAL: General visit preparation materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Pharmacology of FYU-981 (Effect on QT/QTc Interval)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: FYU-981|DRUG: Placebo|DRUG: Moxifloxacin|DRUG: Moxifloxacin Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Guanfacine on Opioid-induced Hyperalgesia (OIH) and Tolerance
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Pain
Interventions: DRUG: Morphine|DRUG: Guanfacine 1mg|DRUG: Guanfacine 2mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Whole-target Consolidation Therapy Under Systemic Therapy for Oligometastatic Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Camrelizumab, gemcitabin, cisplatin|RADIATION: Stereotactic Body Radiotherapy, Intensity modulated-radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LUME-Columbus: Nintedanib Plus Docetaxel in Advanced Non-small Cell Lung Cancer With Translational Research
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: docetaxel|DRUG: docetaxel|DRUG: placebo|DRUG: nintedanib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Link Between BRCA Mutation and Endothelial Function
Status: UNKNOWN
Conditions: BRCA1 Gene Mutation|BRCA2 Gene Mutation
Interventions: OTHER: Endothelial function assessment|OTHER: Cardiovascular biomarkers|OTHER: Endothelial cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Fish Oil Supplementation, Nutrigenomics and Colorectal Cancer Prevention
Status: COMPLETED
Conditions: Colorectal Adenomatous Polyps
Interventions: DRUG: Eicosapentanoic acid and docosahexanoic acid|DRUG: Oleic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Understand the Long-term Safety and Effects of an Experimental Gene Therapy for Duchenne Muscular Dystrophy.
Status: RECRUITING
Conditions: Duchenne Muscular Dystrophy
Interventions: BIOLOGICAL: fordadistrogene movaparvovec
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Gravitas Feeding Tube System Placement Validation in Neonates
Status: RECRUITING
Conditions: Nasogastric Tube
Interventions: DEVICE: Gravitas FT and Gravitas FT Monitor guidance|DEVICE: Gravitas FT System without placement guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of the Safety of IMOVAX Polio™ in China
Status: COMPLETED
Conditions: Poliomyelitis|Polio
Interventions: BIOLOGICAL: IMOVAX Polio™-Inactivated types 1, 2, and 3 poliovirus D vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Three-min Step Test and Exercise Desaturation Detection in Chronic Respiratory Insufficiency Patients
Status: UNKNOWN
Conditions: COPD|Chronic Respiratory Disease
Interventions: DIAGNOSTIC_TEST: Three-min Step Test and Exercise desaturation detection in COPD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Endometrial Cancer|Kidney Cancer|Metastatic Cancer|Ovarian Cancer|Pheochromocytoma|Sarcoma
Interventions: BIOLOGICAL: filgrastim|DRUG: doxorubicin hydrochloride|DRUG: ifosfamide|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Evidence-based Nursing Practices Training Program on the Competency of Nurses Caring for Mechanically Ventilated Patients
Status: COMPLETED
Conditions: Nursing Caries|Practice Nurse's Scope|Competence
Interventions: OTHER: Trianing program for nurse in how to provide evidence based practices for mechanically Ventilated Patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Once Monthly Intravenous Mircera for the Maintenance Treatment of Dialysis Patients With Chronic Renal Anemia.
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: methoxy polyethylene glycol-epoetin beta [Mircera]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Avandia™ + Amaryl™ or Avandamet™ Compared With Metformin (AVALANCHE™ Study)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Avandamet|DRUG: Avandia and Amaryl|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Three-Stair-Position on Improvement of Apnea of Prematurity
Status: COMPLETED
Conditions: Apnea of Prematurity
Interventions: BEHAVIORAL: Three-stair-position|BEHAVIORAL: Head elevated tilt position group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Learn About Effect of Sisunatovir in Healthy Adult Male Participants
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: DRUG: 200 mg RV521/78 µCi [ 14C]-RV521.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiometabolic Effects of Aerobic Exercise Plus Breaking Sitting
Status: COMPLETED
Conditions: Sedentary Behaviour|Sedentary Time
Interventions: OTHER: Aerobic exercise+6.5 h of prolonged sitting|OTHER: Aerobic exercise+2 minutes of walking breaks every 30 minutes|OTHER: Aerobic exercise+4 minutes of walking breaks every 1-h|OTHER: Aerobic exercise+8 minutes of walking breaks every 2-h
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER