pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of Empagliflozin an SGLT2-Inhibitor on Healthy Volunteers With Induced Hypotonic Hyponatremia - the DIVE Study
Status: COMPLETED
Conditions: Inappropriate ADH Syndrome
Interventions: OTHER: Induced hypotonic hyponatremia - SIAD model|DRUG: Empagliflozin 25mg Tbl|DRUG: Placebo P-Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Surgical Approach on Residual Limping After Total Hip Arthroplasty
Status: RECRUITING
Conditions: Hip Osteoarthritis|Muscle Weakness|Muscle Atrophy|Muscle Injury|Arthroplasty Complications
Interventions: PROCEDURE: Lateral approach|PROCEDURE: Posterior approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Frailty for Older Cancer Survivors Using Supplements
Status: COMPLETED
Conditions: Frailty|Inflammation
Interventions: DRUG: Epigallocatechin-3-Gallate (EGCG) plus Ascorbic Acid (Vitamin C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Application of Photosensitive Hydrogel in Intranasal Endoscopic Dacryocystorhinostomy
Status: RECRUITING
Conditions: Chronic Dacryocystitis
Interventions: DEVICE: Photosensitive hydrogel|DEVICE: 6-0 absorbable stitches
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Elective Internal Mammary Node Irradiation in Women With Node-positive Breast Cancer
Status: UNKNOWN
Conditions: Breast Neoplasms
Interventions: RADIATION: Internal mammary node irradiation|RADIATION: No internal mammary node irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in Rosacea
Status: RECRUITING
Conditions: Rosacea|Systemic Inflammation
Interventions: DIETARY_SUPPLEMENT: Skin Barrier Oral Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VBN-EBUS-GS-TBLB With or Without Fluoroscopy for the Diagnosis of PPLs
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DEVICE: VBN|DEVICE: EBUS-GS|DEVICE: X-ray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: RAD001 in Combination With CP-751,871 in Patients Wtih Advanced Sarcomas and Other Malignant Neoplasms
Status: COMPLETED
Conditions: Sarcoma|Solid Tumor
Interventions: DRUG: RAD001|DRUG: CP-751,871
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Balloon Induction of Labor in PROM for TOLAC
Status: UNKNOWN
Conditions: Previous; Cesarean Section, Cicatricial, Complicating Pregnancy or Childbirth, Affecting Fetus or Newborn|Prelabor Rupture of Membranes
Interventions: DEVICE: Double Balloon catheter for induction of labor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rotation for Optimal Targeting of Albuminuria and Treatment Evaluation (ROTATE-2)
Status: WITHDRAWN
Conditions: Diabetic Nephropathy Type 2
Interventions: DRUG: Linagliptin|DRUG: Empagliflozin|DRUG: Telmisartan|DRUG: Sulodexide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AeriSeal® System for Lung Volume Reduction in Patients With Advanced Emphysema
Status: COMPLETED
Conditions: Pulmonary Emphysema|COPD|Lung Diseases
Interventions: DEVICE: AeriSeal System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Using Nanochitosan Versus Calcium Hydroxide as Disinfectant on Pain and Apical Bone Healing
Status: UNKNOWN
Conditions: Postoperative Pain|Healing
Interventions: DRUG: Chitosan|DRUG: Calcium Hydroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Abemaciclib (LY2835219) With Abiraterone in Men With Prostate Cancer That Has Spread to Other Parts of the Body and is Expected to Respond to Hormonal Treatment (Metastatic Hormone-Sensitive Prostate Cancer)
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostatic Neoplasms|Neoplasm Metastasis|Urogenital Neoplasms|Physiological Effects of Drugs|Antineoplastic Agents|Antineoplastic Agents, Hormonal|Androgens|Hormones|Hormones, Hormone Substitutes, and Hormone Antagonists|Abiraterone Acetate|Steroid Synthesis Inhibitors|Cytochrome P-450|Enzyme Inhibitors|Prednisone|Prednisolone|Cyclin-Dependent Kinase 4|Cyclin-Dependent Kinase 6
Interventions: DRUG: Abemaciclib|DRUG: Abiraterone|DRUG: Prednisone or Prednisolone|DRUG: Placebo for Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dabrafenib and Trametinib Combination as a Neoadjuvant Strategy in BRAF-positive Anaplastic Thyroid Cancer
Status: WITHDRAWN
Conditions: Thyroid Gland Anaplastic Carcinoma
Interventions: DRUG: Dabrafenib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequenced vs. Integrated Delivery of Treatment for Adolescent Depression and SUD
Status: COMPLETED
Conditions: Adolescent|Depression|Substance Use Disorders
Interventions: BEHAVIORAL: Adolescent Coping With Depression/Functional Family Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Levofloxacin Sequential Therapy and Quadruple Therapy in Second Line Treatment for HP
Status: COMPLETED
Conditions: Helicobacter
Interventions: DRUG: Levofloxacin based sequential therapy|DRUG: bismuth quadruple therapy for 10 days (BQ)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Shared Care of ADHD in a Pediatric Clinic:Colocation of a Psychologist as an ADHD Care Manager
Status: UNKNOWN
Conditions: ADHD
Interventions: OTHER: Shared Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Electromagnetic Navigation Versus CT Guided TTNA in the Diagnosis of Early Peripheral Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DEVICE: Electromagnetic Navigation guided transthoracic needle aspiration|DEVICE: CT-guided Transthoracic Needle Aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Gemcitabine Hydrochloride, Oxaliplatin, and Erlotinib Hydrochloride in Treating Patients With Advanced Biliary Tract Cancer, Pancreatic Cancer, Duodenal Cancer, or Ampullary Cancer
Status: COMPLETED
Conditions: Extrahepatic Bile Duct Cancer|Gallbladder Cancer|Liver Cancer|Pancreatic Cancer|Periampullary Adenocarcinoma|Small Intestine Cancer
Interventions: DRUG: erlotinib hydrochloride|DRUG: gemcitabine hydrochloride|DRUG: oxaliplatin|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venlafaxine Augmentation in Treatment Resistant Depression
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Venlafaxine|DRUG: Quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab (MEDI4736) and Radiosurgery (fSRT vs. PULSAR) for the Treatment of Non-Small Cell Lung Cancer Brain Metastases
Status: NOT_YET_RECRUITING
Conditions: Brain Metastases From Non-small Cell Lung Cancer
Interventions: RADIATION: Stereotactic Radiation Therapy|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors
Status: RECRUITING
Conditions: Select Advanced Solid Tumors
Interventions: DRUG: IMC-F106C|DRUG: IMC-F106C and pembrolizumab|DRUG: IMC-F106C and chemotherapy|DRUG: IMC-F106C and monoclonal antibodies and chemotherapy|DRUG: IMC-F106C and tebentafusp|DRUG: IMC-F106C and bevacizumab|DRUG: IMC-F106C and kinase inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Two Formulations of Torasemide Tablet 10 mg in Healthy Volunteers Under Fasting Conditions
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Torasemide tablet 10 mg|DRUG: Toradiur® tablet 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Paracervical Block for Pain Control in First Trimester Abortion
Status: COMPLETED
Conditions: Legal Abortion With Complication|Pain
Interventions: PROCEDURE: Paracervical Block|PROCEDURE: Sham Paracervical Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Toripalimab for Patients With Locally Advanced or Metastatic Bladder Urothelial Carcinoma
Status: UNKNOWN
Conditions: Bladder Urothelial Carcinoma
Interventions: BIOLOGICAL: humanized anti-PD-1 monoclonal antibody toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biological and Clinical Effects of Palbociclib With Ovarian Suppression and Letrozole in the Neoadjuvant Treatment of Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Letrozole|DRUG: Palbociclib|DRUG: Goserelin|DIAGNOSTIC_TEST: Oncotype DX Breast Recurrence Score
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extreme Bipolar Androgen Therapy With Darolutamide and Testosterone Cypionate in Patients With Metastatic Castration-Resistant Prostate Cancer (ExBAT Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Testosterone Cypionate|DRUG: Darolutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Gather Information About the Proper Dosing of the Oral FXIa Inhibitor BAY 2433334 and to Compare the Safety of the Study Drug to Apixaban, a Non-vitamin K Oral Anticoagulant (NOAC) in Patients With Irregular Heartbeat (Atrial Fibrillation) That Can Lead to Heart-related Complications.
Status: COMPLETED
Conditions: Atrial Fibrillation (AF)
Interventions: DRUG: BAY2433334|DRUG: Apixaban|OTHER: BAY2433334 matching placebo|OTHER: Apixaban matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ambroxol as a Treatment for Parkinson's Disease Dementia
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson's Disease Dementia
Interventions: DRUG: Ambroxol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Gait Rehabilitation With Dual Task in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: rehabilitation gait with dual task|OTHER: rehabilitation gait without dual task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Radiology Versus Chemotherapy for Recurrent/Progressive Glioblastoma After Second-Line Chemotherapy
Status: COMPLETED
Conditions: Recurrent or Progressive Glioblastoma
Interventions: DRUG: Bevacizumab|DRUG: Chemotherapy|RADIATION: Fractionated radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin B12 Supplementation During Pregnancy on Cognitive Development
Status: ACTIVE_NOT_RECRUITING
Conditions: Pregnancy Related|Vitamin B 12 Deficiency|Anemia
Interventions: DIETARY_SUPPLEMENT: cobalamin|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Quantitative MR Parameters in Non-myelopathic Degenerative Cervical Spinal Cord Compression: a Longitudinal Study.
Status: RECRUITING
Conditions: Degenerative Cervical Spinal Myelopathy|Cervical Spinal Cord Compression
Interventions: DIAGNOSTIC_TEST: MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Hypo-fractionated Proton Radiation for Low Risk Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: Proton Radiation Hypofractionation|RADIATION: Proton Radiation Standard Fractionation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Cooling Helmet for Neuroprotection Management in Open Heart Surgery
Status: COMPLETED
Conditions: Heart; Surgery, Heart, Functional Disturbance as Result
Interventions: DEVICE: Cooling helmet on|DEVICE: Cooling helmet off
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Adults 56 Years and Older
Status: COMPLETED
Conditions: Meningitis|Meningococcal Meningitis|Meningococcal Infections
Interventions: BIOLOGICAL: Meningococcal Polysaccharide (Serogroups A, C, Y, and W) Tetanus Toxoid Conjugate Vaccine|BIOLOGICAL: Meningococcal Polysaccharide Vaccine, Groups A, C, Y, and W-135 Combined
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Embryo Selection by Noninvasive Preimplantation Genetic Test
Status: RECRUITING
Conditions: Infertility|Chromosome Abnormality
Interventions: DIAGNOSTIC_TEST: Non-invasive chromosome screening（NICS）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Safety and Efficacy of the Tao Facemask for Positive Pressure Ventilation in the Patients With Significantly Elevated BMIs
Status: COMPLETED
Conditions: Anesthesia Induction Ventilation
Interventions: DEVICE: Tao Mask|DEVICE: Standard Mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: O6-benzylguanine Followed by Surgery in Treating Patients With Solid Tumors That Can Be Removed During Surgery
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: O6-benzylguanine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing MRI/Ultrasound Fusion-guided Prostate Biopsy Versus Systematic Transrectal Ultrasound-guided Biopsy
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DEVICE: Systematic transrectal ultrasound-guided prostate biopsy|DEVICE: MRI/ultrasound fusion-guided prostate biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Chest Physiotherapy Effects on Intracranial Pressure
Status: COMPLETED
Conditions: Acute Brain Injury
Interventions: PROCEDURE: rapid thoracic compression technique|PROCEDURE: inferior limb passive mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial on the Efficacy and Safety of Two Different Glucocorticoid Dose Regimens in Allergic Bronchopulmonary Aspergillosis
Status: COMPLETED
Conditions: Allergic Bronchopulmonary Aspergillosis
Interventions: DRUG: Glucocorticoids|DRUG: Glucocorticoids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Right Ventricular Involvement in Inferior Myocardial Infarction Patients Using 2 Dimensional Speckle Tracking Echocardiography
Status: UNKNOWN
Conditions: Acute Myocardial Infarction of Inferior Wall Involving Right Ventricle (Disorder)
Interventions: DIAGNOSTIC_TEST: Two dimensional Echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Diffusion Tensor Weighted MRI in Alzheimer's Disease Modifying Treatment Effects of Galantamine (Reminyl®)
Status: UNKNOWN
Conditions: Alzheimer's Disease
Interventions: DRUG: Galantamine (Reminyl®)|DRUG: Placebo/Galantamine (Reminyl®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study of Ketorolac Treatment for Cachexia in Patients With Advanced Pancreatic Ductal Adenocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreas Cancer|Pancreatic Ductal Adenocarcinoma|Pancreatic Cancer
Interventions: DRUG: Ketorolac Tromethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 1, Double-blind, Randomized, Placebo-controlled, Single- and Multiple-dose Escalating Study
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Placebo|DRUG: PB 718
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: How Does the Clinical and Paraclinical Efficacy of an Oral Appliance Evolved According to Propulsion: Control With Each mm of Advancement
Status: COMPLETED
Conditions: Sleep Apnea Syndromes|Sleep Apnea, Obstructive|Respiratory Tract Diseases
Interventions: BEHAVIORAL: questionnaires: Epworth Sleepiness Scale; Pichot fatigue questionnaire.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Autologous Mesenchymal Stromal Cells for Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing-Remitting Multiple Sclerosis|Secondary Progressive Multiple Sclerosis
Interventions: DRUG: XCEL-MC-ALPHA|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Correlation Between Endoscopic Findings And Helicobacter Pylori Infection In Chronic Kidney Disease Patients
Status: RECRUITING
Conditions: Chronic Kidney Diseases
Interventions: DEVICE: esophagogastroduodenoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: LAW Trial -The Impact of Local Anesthetics Infiltration in Surgical Wound of Gastrointestinal Procedures
Status: UNKNOWN
Conditions: Surgical Site Infection|Wound Infection|Postoperative Pain|Local Anesthetics
Interventions: DRUG: Infiltration of 0.5% Bupivacaine|DRUG: Placebo: Infiltration of 0.9% Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery
Status: UNKNOWN
Conditions: Colon Cancer|Colon Diverticulosis|Colonic Neoplasms|Colonic Diverticulitis|Pain, Postoperative|Ileus|Ileus Paralytic|Ileus; Mechanical|Constipation Drug Induced|Constipation|Rectum Cancer|Rectum Neoplasm
Interventions: DRUG: Acetaminophen|DRUG: Gabapentin|DRUG: Orphenadrine|DRUG: Lidocaine|DRUG: Marcaine|DRUG: Ketamine|DRUG: Methadone|DRUG: Tramadol|DRUG: Ketorolac|DRUG: Morphine Sulfate|DRUG: Fentanyl|DRUG: Dilaudid|DRUG: Hydrocodone-Acetaminophen Tab 5-325 MG|DRUG: Morphine Sulfate|DRUG: Fentanyl|DRUG: Dilaudid|DRUG: HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of POMELLA™ Extract to Treat Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: POMELLA™ (pomegranate extract)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Abdominal Wall Injections on Abdominal Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Anterior Cutaneous Nerve Entrapment Syndrome
Interventions: DRUG: Abdominal wall injections with lidocaine 2%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Celecoxib in Patients With Crohn's Disease
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: DRUG: Celebrex|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gut Flora and Lipid Metabolism
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Amoxicillin|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tack Optimized Balloon Angioplasty Study of the Tack Endovascular System® in Below the Knee Arteries
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: Tack Endovascular System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PEG-rhG-CSF in Patients With Malignant Solid Tumors Receiving Chemotherapy
Status: COMPLETED
Conditions: Malignant Solid Tumors
Interventions: DRUG: PEG-rhG-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety, Feasibility, and Efficacy of Non-invasive Vagus Nerve Stimulation (nVNS) in the Treatment of Aneurysmal Subarachnoid Hemorrhage
Status: RECRUITING
Conditions: Subarachnoid Hemorrhage, Aneurysmal
Interventions: DEVICE: gammaCore
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nursing Counseling to the Change of Behavior of Alcohol Consumption in Patients in HAART
Status: COMPLETED
Conditions: HIV|Alcohol Drinking
Interventions: BEHAVIORAL: Nursing Counseling in the change of Alcohol Consumption Behavior in patients receiving HAART|BEHAVIORAL: Habitual Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of TPI-287 in Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: TPI-287 2 mg/m2|DRUG: TPI-287 6.3 mg/m2|DRUG: TPI-287 20 mg/m2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Gypenosides Treatment for Optic Neuritis
Status: TERMINATED
Conditions: Optic Neuritis
Interventions: DRUG: Gypenosides|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Kinect Sensor in Cerebral Palsy Children Phase 2.2
Status: UNKNOWN
Conditions: Cerebral Palsy Children|Upper Extremity Problem
Interventions: DEVICE: The engineer-built system, video-game based Kinect sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Immunogenicity Study of Rotavirus Vaccine Simultaneously Vaccinated With MR or MMR Vaccine
Status: UNKNOWN
Conditions: Rotavirus
Interventions: BIOLOGICAL: rotavirus vaccine|BIOLOGICAL: measles-rubella vaccine|BIOLOGICAL: measles-mumps-rubella vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Cuevas Medek Exercises Children With Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: OTHER: Cuevas Medek|OTHER: Standard kinetic programs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Vadadustat in Hemodialysis Subjects With Anemia Associated With Chronic Kidney Disease
Status: COMPLETED
Conditions: Anemia Associated With Chronic Kidney Disease
Interventions: DRUG: Vadadustat|DRUG: Darbepoetin alfa|DRUG: Epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of PDE-5 Inhibitor and Calcium Channel Inhibitor for the Treatment of Secondary Raynaud Phenomenon
Status: COMPLETED
Conditions: Raynaud Phenomenon
Interventions: DRUG: Udenafil or Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Oral Desipramine With and Without Concomitant Administration of Crobenetine Infusion in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Desipramine tablet|DRUG: Crobenetine infusion|DRUG: Placebo infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Serratus Anterior Plane Block for Rib Fractures
Status: RECRUITING
Conditions: Rib Fracture Multiple
Interventions: PROCEDURE: Serratus Anterior Plane Block (SAPB)|DRUG: Standard Analgesic Medications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Intravitreal Ranibizumab With or Without Macular Laser Photocoagulation for ME Secondary to BRVO
Status: COMPLETED
Conditions: Branch Retinal Vein Occlusion|Ranibizumab|Laser Photocoagulation
Interventions: PROCEDURE: Ranibizumab combined macular laser|DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial to Study Combined Pulsed Dye Laser and Rapamycin Treatment of Port Wine Stain Birthmarks.
Status: COMPLETED
Conditions: Port Wine Stain
Interventions: DRUG: Laser and rapamycin versus laser alone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomised Controlled Trial on LESS Versus Conventional Laparoscopic Appendicectomy.
Status: COMPLETED
Conditions: Appendicitis
Interventions: PROCEDURE: LESS appendectomy|PROCEDURE: Conventional 3-port laparoscopic appendectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dapagliflozin on Hepatic and Renal Glucose Metabolism Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Process and Outcomes of Horticultural Therapy for People With Disabilities
Status: COMPLETED
Conditions: Mental Disorders, Severe|Intellectual Disability
Interventions: BEHAVIORAL: Horticultural therapy|OTHER: Comparison
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RCT of the Double Wire Technique for Sphincterotomy
Status: TERMINATED
Conditions: Cholangiopancreatography, Endoscopic Retrograde|Sphincterotomy, Endoscopic|VATER'S AMPULLA
Interventions: PROCEDURE: Transpancreatic sphincterotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Propofol on Early Recovery of Hunger After Surgery
Status: COMPLETED
Conditions: Ambulatory Surgery|Anesthesia|Energy Expenditure|Food Intake
Interventions: DRUG: propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Intervention With Black Currant Seed Press Residues in Healthy Subjects
Status: COMPLETED
Conditions: Smoking
Interventions: DIETARY_SUPPLEMENT: black currant seed press residue|DIETARY_SUPPLEMENT: Bread without black currant seed press residues|DIETARY_SUPPLEMENT: Baseline data
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: STREAMLINE®SURGICAL SYSTEM Compared to iStent Inject W® in Patients With Open-Angle Glaucoma
Status: RECRUITING
Conditions: Open Angle Glaucoma
Interventions: DEVICE: Streamline Surgical System|DEVICE: iStent Inject W
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: REGN5381 in Heart Failure Adult Participants With Elevated Pulmonary Capillary Wedge Pressure
Status: RECRUITING
Conditions: Heart Failure
Interventions: DRUG: REGN5381|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CRISPR (HPK1) Edited CD19-specific CAR-T Cells (XYF19 CAR-T Cells) for CD19+ Leukemia or Lymphoma.
Status: UNKNOWN
Conditions: Leukemia Lymphocytic Acute (ALL) in Relapse|Leukemia Lymphocytic Acute (All) Refractory|Lymphoma, B-Cell|CD19 Positive
Interventions: GENETIC: XYF19 CAR-T cell|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravascular Balloon Lithotripsy in Left Main Stem Percutaneous Coronary Intervention
Status: UNKNOWN
Conditions: Coronary Artery Calcification|Left Main Coronary Artery Disease
Interventions: DEVICE: Left main stenting with intravascular lithotripsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Falls With Progressive Resistance Training for the Oldest Old Adults With Sarcopenia
Status: ENROLLING_BY_INVITATION
Conditions: Sarcopenia|Aging
Interventions: BEHAVIORAL: High-intensity progressive resistance training|OTHER: General practitioner care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Effect on Lung Function of BDA Formulated With a New Propellant (HFO) Compared With an Approved Asthma Treatment (BDA With HFA Propellant) in Participants With Asthma
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: BDA MDI HFO 160/180 μg|DRUG: BDA MDI HFA 160/180 μg|DRUG: Placebo MDI HFA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Magnesium Isoglycyrrhizinate Injection in Subjects With Acute Drug-induced Liver Injury
Status: COMPLETED
Conditions: Drug-Induced Liver Injury
Interventions: DRUG: Magnesium Isoglycyrrhizinate Injection 100mg OD|DRUG: Magnesium Isoglycyrrhizinate Injection 200mg OD|DRUG: Tiopronin Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of Dysphagia Evaluation Via Video Analysis Based on Deep Learning Method in Neonates and Infants and Correlation Between the Evaluation and the Development
Status: RECRUITING
Conditions: Dysphagia of Newborn
Interventions: DIAGNOSTIC_TEST: AI analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hand Exercises for Women With Rheumatoid Arthritis and Impaired ADL Ability: an Exploratory Trial
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Hand Exercise|OTHER: Compensatory Intervention Program (CIP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mobilization With Movement Techniques of Shoulder Girdle in Patients With Chronic Adhesive Capsulitis
Status: COMPLETED
Conditions: Adhesive Capsulitis of Shoulder
Interventions: OTHER: mobilization with movement|OTHER: conventional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Finding Study of CycloSam® Combined With External Beam Radiotherapy
Status: WITHDRAWN
Conditions: Osteosarcoma|Bone Metastases
Interventions: DRUG: 153Sm-DOTMP|RADIATION: External beam radiotherapy.|DRUG: Calcium Carbonate|DRUG: Mozobil|DRUG: Neupogen Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Fidelity of a Gross Motor-based Physical Activity Intervention on Cognition in Preschool-age Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Activity, Motor
Interventions: BEHAVIORAL: Movement and Cognition Intervention Group|BEHAVIORAL: Health Tracker Group (Control Group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ActiPatch Plantar Fasciitis Clinical Trial
Status: COMPLETED
Conditions: Plantar Fasciitis|Plantar Fasciopathy
Interventions: DEVICE: Sham pulsed radio-frequency electromagnetic device|DEVICE: ActiPatch PRFE Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Randomised Trial of First and Second Line Treatments of RCT of First and Second Line H Pylori Treatments in Slovenia
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection|Eradication Treatments
Interventions: DRUG: Esomeprazole 40mg, Clarithromycin 500 mg, Metronidazole 400 mg,|DRUG: Esomeprazole 40mg, Bismuth subcitrate 120 mg, Amoxicillin 500 mg, Metronidazole 400 mg|DRUG: Esomeprazole 40mg, Bismuth subcitrate 120 mg, Amoxicillin 500 mg, Metronidazole 400 mg|DRUG: Esomeprazole 40mg, Amoxicillin 500 mg, Levofloxacin 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma
Status: COMPLETED
Conditions: Anaplastic Astrocytoma|Anaplastic Oligoastrocytoma|Diffuse Intrinsic Pontine Glioma|Gliosarcoma
Interventions: RADIATION: 3-Dimensional Conformal Radiation Therapy|RADIATION: Intensity-Modulated Radiation Therapy|OTHER: Laboratory Biomarker Analysis|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of PRP for Treatment of Disc Pain
Status: COMPLETED
Conditions: Discogenic Pain
Interventions: DEVICE: High yield pure PRP|OTHER: Placebo|DEVICE: ProPlaz PPC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Iodine-containing Multiple Micronutrient During Lactation on Infant Neurodevelopment
Status: NOT_YET_RECRUITING
Conditions: Iodine Deficiency|Nutrition Poor|Development, Infant|Breastfeeding
Interventions: DIETARY_SUPPLEMENT: UNIMAP Multiple Micronutrient Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Beliefs About Medication in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Musculoskeletal Diseases|Rheumatoid Arthritis
Interventions: BEHAVIORAL: Patient-centered group intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Optimizing a Multi-Modal Intervention to Reduce Health-Risking Sexual Behaviors: Component Selection
Status: COMPLETED
Conditions: Sexually Transmitted Infections|Pregnancy, Unplanned|Military Personnel
Interventions: BEHAVIORAL: Basic Education ("Education")|BEHAVIORAL: Narrative Videos ("Narratives")|BEHAVIORAL: Skills Building Videos ("Skills")|BEHAVIORAL: Interactive Scenarios ("Scenarios")|BEHAVIORAL: Future Life Planning Tool ("Future")|BEHAVIORAL: Epidemiological Risk Scenario ("Risk")
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Performance of Ultrasound in Women With Postmenopausal or Abnormal Uterine Bleeding Between White and Black Ethnic Groups- a Retrospective Cohort Study.
Status: ACTIVE_NOT_RECRUITING
Conditions: Postmenopausal Bleeding|Endometrial Cancer
Interventions: DIAGNOSTIC_TEST: Ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Efficacy of Naproxen Versus Ibuprofen
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Comparison of Efficacy of Naproxen versus Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: GV1001 and Gemcitabine in Sequential Combination to Gemcitabine Monotherapy in Pancreatic Cancer
Status: TERMINATED
Conditions: Advanced Unresectable Pancreatic Cancer
Interventions: BIOLOGICAL: GV1001|DRUG: Gemcitabine (Chemotherapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of 2 Different Broccoli Sprout Containing Supplements on Nasal Cells in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Adult Volunteers
Interventions: DIETARY_SUPPLEMENT: Supplement A followed by Supplement B|DIETARY_SUPPLEMENT: Supplement B followed by Supplement A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Pretreatment to Promote Graft Survival After Subsequent High-risk Corneal Transplantation [CrossCornealVision]
Status: RECRUITING
Conditions: Corneal Transplantation
Interventions: DEVICE: Corneal Crosslinking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetuximab + Best Supportive Care Compared With Best Supportive Care Alone in Metastatic Epidermal Growth Factor Receptor-Positive Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Quality of Life
Interventions: BIOLOGICAL: cetuximab|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
Status: RECRUITING
Conditions: Age-Related Macular Degeneration|Allergies|Alpha-Gal Syndrome|Alzheimer Disease|Amyloidosis|Ankylosing Spondylitis|Arthritis|Alopecia Areata|Asthma|Atopic Dermatitis|Autism|Autoimmune Hepatitis|Behcet's Disease|Beta-Thalassemia|Cancer|Celiac Disease|Kidney Diseases|COPD|Crohn Disease|Cystic Fibrosis|Diabetes|Dravet Syndrome|DMD|Fibromyalgia|Graves Disease|Thyroid Diseases|Hepatitis|Hidradenitis Suppurativa|ITP|Leukemia|ALS|Lupus or SLE|Lymphoma|Multiple Sclerosis|Myasthenia Gravis|Heart Diseases|Parkinson Disease|Pemphigus Vulgaris|Cirrhosis|Psoriasis|Schizophrenia|Scleroderma|Sickle Cell Disease|Stroke|Ulcerative Colitis|Vasculitis|Vitiligo
Interventions: DIAGNOSTIC_TEST: Specimen sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of OR502, a Monoclonal Antibody Targeting LILRB2, Alone and in Combination With Anticancer Agents
Status: RECRUITING
Conditions: Cancer|Tumor, Solid|Malignant Neoplasm|Metastatic Cancer|Advanced Solid Tumor|Platinum-resistant Ovarian Cancer|Cutaneous Squamous Cell Carcinoma
Interventions: DRUG: OR502|DRUG: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Intravenous Mircera for the Treatment of Anemia in Dialysis Patients.
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Darbepoetin alfa|DRUG: methoxy polyethylene glycol-epoetin beta [Mircera]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Tolerability, Safety, Pharmacokinetics and Preliminary Efficacy of PF-114 for Oral Administration in Adults With Ph+ Chronic Myeloid Leukemia, Which is Resistant to the 2-nd Generation Bcr-Abl Inhibitors or Has T315I Mutation in the BCR-ABL Gene
Status: UNKNOWN
Conditions: Chronic Myeloid Leukemia|Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Interventions: DRUG: PF-114
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Curcumin Supplementation in Patients With Chronic Kidney Disease on Peritoneal Dialysis
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Peritoneal Dialysis|Hemodialysis
Interventions: DIETARY_SUPPLEMENT: Curcumin supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Multiple Ascending Dose Trial of MSB0010841 (Anti-IL17A/F Nanobody) in Psoriasis Subjects
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: MSB0010841|DRUG: MSB0010841|DRUG: MSB0010841|DRUG: MSB0010841|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CONtrolling Disease Using Inexpensive IT - Hypertension in Diabetes
Status: COMPLETED
Conditions: Hypertension|Diabetes Mellitus
Interventions: OTHER: Self-monitoring-nurse-primary care provider feedback loop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Ewing Sarcoma
Status: RECRUITING
Conditions: Refractory Ewing Sarcoma|Relapsed Ewing Sarcoma|Ewing Sarcoma
Interventions: DRUG: Lurbinectedin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Semi-rigid Ureteroscopic Laser Lithotripsy in the Treatment of Proximal Ureteral Stones: a Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Urolithiasis|Proximal Ureteral Stone
Interventions: DEVICE: Thulium Fiber laser (TFL) lithotripsy|DEVICE: Ho: YAG lithotripsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Remote Endarterectomy and Endovascular Treatments in Patients With the Femoral Artery Occlusive Disease
Status: UNKNOWN
Conditions: Steno-occlusive Desease of Femoro-popliteal Arterial Segment
Interventions: PROCEDURE: Angioplasty with stenting of the femoral artery|PROCEDURE: Open surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture Effect on Dumping Syndrome in Esophagus Cancer Patients With Feeding Jejunostomy
Status: RECRUITING
Conditions: Esophagus Cancer|Acupuncture
Interventions: OTHER: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE