pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: APPROACH Study: Quality of Life and Outcomes Assessment in Participants With Chronic Hepatitis C (CHC) Treated With Pegylated Interferon (PEG-IFN) Alfa-2a and Ribavirin
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Pegylated interferon (PEG-INF) alfa-2a|DRUG: Ribavirin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess Intrahepatic and Peripheral Changes of Immunologic and Virologic Markers in Chronic Hepatitis B Virus Infection
Status: COMPLETED
Conditions: Hepatitis B
Interventions: DRUG: JNJ-73763989|DRUG: JNJ-56136379|DRUG: Entecavir (ETV)|DRUG: Tenofovir disoproxil|DRUG: Tenofovir alafenamide (TAF)|DRUG: PegIFN-alpha-2a (Optional)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study Using Plasma for Patients Requiring Emergency Surgery
Status: WITHDRAWN
Conditions: Hemorrhagic Shock|Blood Coagulation Disorders|Blood Products|Trauma|Ruptured AAA
Interventions: DRUG: Human Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study in Patients With HPV16+ Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer|HPV Positive Oropharyngeal Squamous Cell Carcinoma|HPV-Related Carcinoma
Interventions: DRUG: CUE-101|DRUG: KEYTRUDA®, Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lymphocyte Therapy in Treating Patients With Kidney Cancer
Status: UNKNOWN
Conditions: Kidney Cancer
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: muromonab-CD3|BIOLOGICAL: therapeutic autologous lymphocytes|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: An Umbrella Trial Based on Molecular Pathway for Patients With Metastatic TNBC.
Status: ACTIVE_NOT_RECRUITING
Conditions: TNBC - Triple-Negative Breast Cancer
Interventions: DRUG: A1: Pyrotinib with nab-paclitaxel|DRUG: A2: nab-paclitaxel|DRUG: B1: everolimus with nab-paclitaxel|DRUG: B2: nab-paclitaxel|DRUG: C1: PD-1 with nab-paclitaxel and famitinib|DRUG: C2: nab-paclitaxel|DRUG: D1: VEGFR and nab-paclitaxel, with maintenance of VEGFR and capecitabine|DRUG: D2: nab-paclitaxel, with maintenance of capecitabine|DRUG: E1: everolimus with nab-paclitaxel|DRUG: E2: nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Cetylpyridinium Chloride (CPC) Rinse in Viral Upper Respiratory Tract Infections (vURTI)
Status: COMPLETED
Conditions: Viral Pharyngitis
Interventions: DRUG: CPC mouthwash|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity of VPM1002 Vaccination or BCG Revaccination Against TB in Pre-Adolescents Living With and Without HIV in South Africa
Status: WITHDRAWN
Conditions: Tuberculosis|HIV Infections
Interventions: BIOLOGICAL: VPM1002 Vaccine|BIOLOGICAL: BCG Vaccine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adipose Derived Regenerative Cells In the Treatment of Diabetic Foot Ulcers
Status: NOT_YET_RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: ADRCs|OTHER: standard care|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxygen-Ozone as Adjuvant Treatment in Early Control of COVID-19 Progression and Modulation of the Gut Microbial Flora
Status: UNKNOWN
Conditions: COVID|SARS-CoV 2|Pneumonia, Viral|Coronavirus Infection
Interventions: OTHER: Oxygen-ozone therapy, probiotic supplementation and Standard of care|DIETARY_SUPPLEMENT: SivoMixx (200 billion)|DRUG: Azithromycin|DRUG: hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Basic Research of ETV Plus GM-CSF in Chronic Hepatitis B Patients
Status: TERMINATED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Granulocyte Macrophage-colony Stimulating Factor|DRUG: Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Oxygen Concentration and Neurocognition After Cardiac Surgery
Status: UNKNOWN
Conditions: Hyperoxia|Normoxic|Delirium
Interventions: OTHER: Normoxic oxygenation|OTHER: Hyperoxic oxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immune Responses to Two Experimental HIV Vaccines in Healthy Adults
Status: COMPLETED
Conditions: HIV Negative|Adaptive Immunity|Innate Immunity
Interventions: BIOLOGICAL: VRC-HIVDNA016-00-VP|BIOLOGICAL: VRC-HIVADV014-00-VP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Acupuncture for Women's Health Conditions
Status: COMPLETED
Conditions: Ovarian Neoplasms|Endometriosis|Pelvic Pain|Uterine Neoplasms
Interventions: PROCEDURE: Chinese Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Ezetimibe Tablets in Healthy Subjects
Status: UNKNOWN
Conditions: Therapeutic Equivalency
Interventions: DRUG: ezetimibe tablets|DRUG: ezetimibe tablets(Ezetrol ®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dapagliflozin in Diabetic Patients (Type 2) With Decompensated Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Dapagliflozin|DRUG: insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FMRI Assessment After Radiofrequency in Trigeminal Neuralgia
Status: UNKNOWN
Conditions: Trigeminal Neuralgia|Pain, Neuropathic
Interventions: PROCEDURE: pulsed Radiofrequency|PROCEDURE: thermal Radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Iontophoresis of Treprostinil to Enhance Wound Healing in Diabetic Foot Skin Ulcers
Status: TERMINATED
Conditions: Diabetic Foot Ulcer
Interventions: DRUG: Treprostinil iontophoresis|DEVICE: Remodulin® placebo iontophoresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Safety and Efficacy of a Modified Technique of Scleral Fixation Intraocular Lens Implantation
Status: UNKNOWN
Conditions: Aphakia|Cataract
Interventions: PROCEDURE: Doubled sutured SFIOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cannabis (THC vs. CBD) in Multiple Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: THC|DRUG: CBD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Performance of CEREGLIDE 92 Intermediate Catheter in Treatment of Acute Ischemic Stroke
Status: NOT_YET_RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DEVICE: Cereglide 92
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Erlotinib for Brain Metastasis of Non-Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-Small Cell Lung Cancer|Brain Metastases
Interventions: DRUG: erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Precision Exercise Therapeutics (PET-pilot)
Status: RECRUITING
Conditions: Overweight|Healthy
Interventions: OTHER: Continuous aerobic exercise|OTHER: High intensity interval training|OTHER: Resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A 2-year Clinical Impact of Bulk-fill Low-viscosity Resin Composite Liners in Class II Restorations.
Status: COMPLETED
Conditions: Dental Caries Class II
Interventions: COMBINATION_PRODUCT: Xtra-fill|COMBINATION_PRODUCT: x-base|COMBINATION_PRODUCT: Admira fusion x-tra|COMBINATION_PRODUCT: Admira fusion x-base
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ALXN1830 Administered Subcutaneously in Adults With Generalized Myasthenia Gravis
Status: WITHDRAWN
Conditions: Generalized Myasthenia Gravis
Interventions: DRUG: ALXN1830|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mycological Comparative Study on Maxillary Dentures of Two Different Materials
Status: UNKNOWN
Conditions: Effect of Tio2 Nanoparticles on Candida Aggregation
Interventions: OTHER: titanium dioxide denture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RICE Trial: Rifaximin In Chronic Hepatic Encephalopathy - A Randomized, Controlled Trial
Status: TERMINATED
Conditions: Hepatic Encephalopathy
Interventions: DRUG: Rifaximin|DRUG: Lactulose|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate Efficacy and Safety of a New Oral Contraceptive
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: EV/DNG (Qlaira, BAY86-5027, SH T00658K)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Safety and Effectiveness of Ganciclovir Used Alone or in Combination With Granulocyte-Macrophage Colony Stimulating Factor in the Treatment of Cytomegalovirus (CMV) of the Eye in Patients With AIDS
Status: COMPLETED
Conditions: Cytomegalovirus Retinitis|HIV Infections
Interventions: DRUG: Zidovudine|DRUG: Sargramostim|DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of BMS-833923 (XL139) in Subjects With Advanced or Metastatic Cancer
Status: COMPLETED
Conditions: Hedgehog Pathway|Smoothened|Basal Cell Carcinoma (BCC)|Basal Cell Nevoid Syndrome (BCNS)
Interventions: DRUG: BMS-833923 (XL139)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Ultrasound to Predict Response to Intraarticular Corticosteroids in Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: triamcinolone acetonide|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Bilateral TAP and RS Blocks Using Liposomal Bupivacaine/Bupivacaine vs. Regular Bupivacaine in Laparoscopic Colectomy
Status: RECRUITING
Conditions: Bowel Disease
Interventions: DRUG: Liposomal Bupivicaine/Bupivacaine Admixture|DRUG: Bupivacaine HCL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Two Phase Extension Trial of SP668 to Investigate the Safety and Tolerability of Sustained Release Fesoterodine in Subjects With Overactive Bladder: a Double-Blind Phase Followed by an Open-Label Extension Phase
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: SPM 907
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, in Subjects With Refractory Generalized Myasthenia Gravis
Status: NOT_YET_RECRUITING
Conditions: Myasthenia Gravis|Generalized Myasthenia Gravis
Interventions: BIOLOGICAL: KYV-101|DRUG: Standard lymphodepletion regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cellular Immunotherapy Study With Autologous Dendritic Cells Loaded With Oncofetal Antigen/iLRP in Patients With Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: BIOLOGICAL: Dendritic Cell Vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Aerobic Interval Training With Vitamin D Supplement on Functional Capacity and Perceived Myalgia
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: OTHER: aerobic interval training and Vitamin D supplementation,|DRUG: Vitamin D supplementation only|OTHER: aerobic interval training only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid vs Maintenance Vitamin D Supplementation in Deficient Children With Asthma to Prevent Exacerbations.
Status: COMPLETED
Conditions: Asthma|Vitamin D Deficiency
Interventions: DRUG: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Incontinence Without Memory Problems
Status: COMPLETED
Conditions: Urge Incontinence|Urinary Incontinence, Urge
Interventions: DRUG: Mirabegron|DRUG: Tolterodine Tartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of CD388 to Prevent Flu in an Influenza Challenge Model in Healthy Adults
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: Saline placebo|COMBINATION_PRODUCT: CD388
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Looking at Biomarkers in Ovarian Cancer
Status: RECRUITING
Conditions: Gynecologic Cancer
Interventions: PROCEDURE: Tumour tissue collection|PROCEDURE: Blood sample collection|PROCEDURE: Ascites Collection|PROCEDURE: Fluid Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of RoActemra/Actemra (Tocilizumab) With or Without Methotrexate in Patients With Mild to Moderate Rheumatoid Arthritis With an Inadequate Response to Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: methotrexate|DRUG: methotrexate|DRUG: placebo|DRUG: tocilizumab [RoActemra/Actemra]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Minoxidil 5% / Botanical Hair Regimen in Men With Thinning Hair and Male Pattern Hair Loss/Androgenic Alopecia
Status: COMPLETED
Conditions: Male Pattern of Hair Loss, Androgenic Alopecia
Interventions: DRUG: Treatment: Minoxidil 5% / Botanical Hair Solution for Men
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Outcomes of Radiofrequency Ablation of Lung Tumors
Status: SUSPENDED
Conditions: NSCLC|Pulmonary Metastases
Interventions: PROCEDURE: Radiofrequency ablation of pulmonary malignancies|BEHAVIORAL: Quality of life assessment|BEHAVIORAL: Assessment of pain
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of CCNU (Lomustine) Plus Dasatinib in Recurrent Glioblastoma (GBM)
Status: TERMINATED
Conditions: Glioblastoma
Interventions: DRUG: Dasatinib|DRUG: Lomustine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Adalimumab in Patients With Moderate to Severely Active Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: BIOLOGICAL: Human anti-TNF monoclonal antibody/adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Explorer Babies Early Intervention Program
Status: COMPLETED
Conditions: Premature|Developmental Disability|Cerebral Palsy|Motor Disorders|Development, Infant
Interventions: BEHAVIORAL: The Explorer Baby Early Intervention Program|OTHER: Neurodevelopmental Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Appetite Response to Exercise- Versus Energy Restriction-induced Energy Deficit in Adolescents With Obesity.
Status: COMPLETED
Conditions: Pediatric Obesity
Interventions: BEHAVIORAL: Con : control condition without exercise / rest condition|BEHAVIORAL: Def-EX : Condition with an exercise-induced energy deficit|BEHAVIORAL: Def-EI : Condition with an energy-restriction energy deficit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CPAP to Reduce Arterial Stiffness in Non Sleepy, Moderate to Severe Obstructive Sleep Apnea (STIFFSLEEP)
Status: TERMINATED
Conditions: Obstructive Sleep Apnea|Vascular Stiffness|Sleep Disorder Daytime Somnolence
Interventions: DEVICE: CPAP (ResMed S9 AutoSet)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of Vaccine CVnCoV in Healthy Adults in Germany for COVID-19
Status: COMPLETED
Conditions: Coronavirus|Covid19|SARS-CoV-2|Severe Acute Respiratory Syndrome
Interventions: BIOLOGICAL: CVnCoV Vaccine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Studying DNA in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian Epithelial Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: GENETIC: DNA methylation analysis|GENETIC: microarray analysis|GENETIC: polymerase chain reaction|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of the Rotator Cuff Disease With Platelet Rich Plasma Injection
Status: COMPLETED
Conditions: Subacromial Impingement Syndrome|Partial Thickness Rotator Cuff Tear
Interventions: BIOLOGICAL: platelet rich plasma injection|DRUG: corticosteroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II, Single-arm, Multicenter, Prospective Study of Cardunolizumab in Recurrent or Metastatic Vulvar and Vaginal Cancer
Status: NOT_YET_RECRUITING
Conditions: Vulvar and Vaginal Cancer
Interventions: DRUG: Cardunolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cost-Effectiveness and Patients Satisfaction of Conventional vs Robotic-Assisted Laparoscopy in Gynecologic Oncologic Indications
Status: COMPLETED
Conditions: UTERINE CERVICAL NEOPLASMS|ENDOMETRIAL NEOPLASMS
Interventions: PROCEDURE: Laparoscopy in Gynecologic Oncologic Indications|PROCEDURE: Conventional surgery (abdominal radical surgery)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Comparing Irinotecan and Cisplatin (IP) With Etoposide and Cisplatin (EP) Following EP/TRT for LD-SCLC
Status: COMPLETED
Conditions: Small-Cell-Lung Cancer
Interventions: DRUG: Etoposide and cisplatin after chemoradiotherapy|DRUG: Irinotecan and cisplatin after chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effective Treatment of Posttraumatic and Postoperative Edema
Status: COMPLETED
Conditions: Edema
Interventions: BEHAVIORAL: ice gel pack|OTHER: Multi-layer compression bandage|DEVICE: A-V Impulse compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Alpha-ketoglutarate Supplementation Lower BiologicaL agE in Middle- Aged Adults?
Status: RECRUITING
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: Ca-AKG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: EMB-01 in Combination With Osimertinib in Patients With EGFR Mutant Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastatic Lung Non-Small Cell Carcinoma|Advanced Lung Non-Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8|Stage III Lung Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|EGFR Mutation-Related Tumors
Interventions: DRUG: EMB-01|DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - General
Status: WITHDRAWN
Conditions: Caries,Dental|Apical Periodontitis
Interventions: DRUG: Kovanaze Nasal Spray|DRUG: Articaine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resident-to-Resident Elder Mistreatment Intervention for Dementia Care in Assisted Living
Status: COMPLETED
Conditions: Assisted Living, Resident to Resident Elder Mistreatment
Interventions: OTHER: R-REM training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: GIP/GLP-1 Co-Activity in Subjects With Overweight and Type 2 Diabetes: Lowering of Food Intake
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Overweight and Obesity
Interventions: BIOLOGICAL: GIP1-42 infusion|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Results of Oxford Unicompartmental Knee Arthroplasty in Patients With and Without Preoperative Genu Recurvatum
Status: COMPLETED
Conditions: Primary Gonarthrosis|Genu Recurvatum
Interventions: DEVICE: Oxford unicompartmental knee arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Project 3 Example: Human-AI Collaboration Tester (HAICT) Exp. 7
Status: RECRUITING
Conditions: Decision Making|Computer Aided Diagnosis
Interventions: BEHAVIORAL: Simulated Second Reader AI|BEHAVIORAL: Target Prevalence
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant ABI-007, Carboplatin and Gemcitabine in Locally Advanced Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: ABI-007|DRUG: Carboplatin|DRUG: Gemcitabine|PROCEDURE: Radical Cystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduction in the Number of Chemotherapy Cycles in Combination With Pembrolizumab in First-line Treatment of PD-L1-positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinomas
Status: NOT_YET_RECRUITING
Conditions: Squamous Cell Carcinoma of Head and Neck
Interventions: DRUG: Once the patient is included in the study, he will receive the treatment schema as defined below:
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of GX-19, a COVID-19 Preventive DNA Vaccine in Healthy Adults
Status: UNKNOWN
Conditions: SARS-CoV-2
Interventions: DRUG: GX-19|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Afamelanotide and Narrow-Band Ultraviolet B (NB-UVB) Light in the Treatment of Nonsegmental Vitiligo
Status: COMPLETED
Conditions: Vitiligo
Interventions: DRUG: Afamelanotide|DEVICE: NB-UVB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II: Decitabine/Vaccine Therapy in Relapsed/Refractory Pediatric High Grade Gliomas/Medulloblastomas/CNS PNETs
Status: TERMINATED
Conditions: Gliomas|Medulloblastoma|Neuroectodermal Tumors, Primitive
Interventions: BIOLOGICAL: Vaccine (autologous dendritic cells)|DRUG: Decitabine and Hiltonol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CA-008 (Vocacapsaicin) in Bunionectomy Patients
Status: COMPLETED
Conditions: Post-surgical Pain
Interventions: DRUG: CA-008|DRUG: Placebo|DRUG: Ketorolac|DRUG: Acetaminophen|DRUG: Oxycodone|DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Exercise After an ICD
Status: NOT_YET_RECRUITING
Conditions: Heart Arrest|Implantable Defibrillator User|Physical Activity
Interventions: BEHAVIORAL: E-ICD Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HIV Self-Testing and Comic Intervention With Refugee Adolescents and Youth
Status: UNKNOWN
Conditions: HIV/AIDS|HIV Infections|Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: Educational comic book|DIAGNOSTIC_TEST: HIV Self-testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the PK of Ketorolac Tromethamine Intranasal and to Assess the Effects of a Oxymetazoline Hydrochloride on the PK of Ketorolac Tromethamine
Status: COMPLETED
Conditions: Assess Pharmacokinetics of Ketorolac Tromethamine Intranasal and Assess Effects of a Oxymetazoline Hydrochloride on the PK of Ketorolac Tromethamine
Interventions: DRUG: Ketorolac tromethamine|DRUG: Oxymetazoline hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VITOM Study: A Randomized, Controlled Trial.
Status: COMPLETED
Conditions: Pelvic Organ Prolapse|Prolapse of Vaginal Vault After Hysterectomy|Bulging of Vaginal Wall|Incontinence|Fistula
Interventions: OTHER: Live Surgery using VITOM|OTHER: Live Surgery without VITOM|OTHER: Video viewing with VITOM|OTHER: Video viewing with standard handheld high-definition camera
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Elotuzumab, Selinexor, and Dexamethasone for Relapsed Refractory Multiple Myeloma
Status: WITHDRAWN
Conditions: Relapsed Multiple Myeloma|Refractory Multiple Myeloma
Interventions: DRUG: Elotuzumab, Selinexor, and Dexamethasone (ESd)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability
Status: ACTIVE_NOT_RECRUITING
Conditions: Cognitive Impairment|Dementia
Interventions: BEHAVIORAL: Nutritional guidance|BEHAVIORAL: Exercise|BEHAVIORAL: Cognitive training|OTHER: Reduction of vascular risk factors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ORal ApplianCes for sLeep Apnea of the Elderly
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea|Hypertension|Cardiovascular Disease
Interventions: DEVICE: Mandibular advancement device|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Pharmacokinetic Study of ATI-50002 in Subjects With Alopecia Universalis (AU) and Alopecia Totalis (AT)
Status: COMPLETED
Conditions: Alopecia Universalis (AU)|Alopecia Totalis (AT)
Interventions: DRUG: Vehicle|DRUG: ATI-50002
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bowel Preparation for Repeat Colonoscopy After Preparation Failure (RepeatPrep Study)
Status: COMPLETED
Conditions: Bowel Preparation for Colonoscopy
Interventions: BEHAVIORAL: Educational telephone intervention|BEHAVIORAL: Standard education for colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Speed of Processing Training for Cognitive Deficits After Delirium in Older Adults
Status: TERMINATED
Conditions: Delirium|Dementia
Interventions: BEHAVIORAL: Speed of Processing Training|BEHAVIORAL: Internet-Based Contact Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Auricular Vagus Nerve Stimulation on the Pro-inflammatory Cytokine Response in Healthy Adults
Status: COMPLETED
Conditions: Cytokine Response to Vagus Nerve Stimulation
Interventions: DEVICE: Vagus Nerve Stimulator|DEVICE: Vagus Nerve Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Treatment Outcomes in Patients Affected by Molar-Incisor Hypomineralization (MIH)
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypomineralization of Enamel|Dental Fear|Quality of Life
Interventions: PROCEDURE: Restorative therapy|PROCEDURE: Extraction therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HTD1801 in Adults With Nonalcoholic Steatohepatitis and Liver Fibrosis Who Have Type 2 Diabetes or Pre-Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Nonalcoholic Steatohepatitis (NASH)|Type 2 Diabetes
Interventions: DRUG: HTD1801|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gallium-68 Prostate Specific Membrane Antigen PET in Diagnosing Patients With Thyroid Cancer
Status: TERMINATED
Conditions: Thyroid Gland Carcinoma
Interventions: DRUG: Gallium Ga 68-labeled PSMA-11|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography (PET)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Sirolimus vs Paclitaxel Drug Eluting Balloon for Below-the-knee Angioplasty in Critical Limb Ischemia
Status: UNKNOWN
Conditions: Critical Limb Ischemia|Drug Effect
Interventions: PROCEDURE: angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: How to Get Started: Identifying the Critical Ingredients to Improve Gait Initiation in Parkinson Disease
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: Postural control (weight shift) training|BEHAVIORAL: Steady state gait training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability of Using the SHR-1210 in Patients With Advanced Melanoma
Status: COMPLETED
Conditions: Advanced Melanoma
Interventions: BIOLOGICAL: SHR-1210
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Stimulation for Mild Traumatic Brain Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Traumatic Brain Injury|Post-Concussion Symptoms
Interventions: DEVICE: Frontal Stimulation|DEVICE: Temporal Stimulation|DEVICE: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Single Ascending Dose, Food Effects and Drug-Drug Interactions of ACC017 Tablets in Healthy Adult Participants
Status: RECRUITING
Conditions: Healthy Adult Participants
Interventions: DRUG: ACC017 tablets|DRUG: Emtricitabine and Tenofovir Alafenamide Fumarate Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Feasibility of Asthma Application of Mobile Phone and Mobile Spirometry for Home Monitor of Asthma Patients
Status: UNKNOWN
Conditions: Asthma
Interventions: OTHER: Health Lung App. of mobile phone+ezOxygen mobile spirometry|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Early-Phase Safety of Proton Therapy Equipment
Status: COMPLETED
Conditions: Malignant Glioma|Hepatocellular Carcinoma|Head and Neck Malignant Tumor|Prostate Cancer
Interventions: RADIATION: proton therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: GID SVF-2 Device System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Goal Directed Therapy After Aneurysmal Subarachnoid Haemorrhage
Status: COMPLETED
Conditions: Aneurysmal Subarachnoid Haemorrhage|SAH
Interventions: DEVICE: PiCCO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Dosing Parameters on Motor Skill Acquisition and Retention in Bilateral Cerebral Palsy (BCP)
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: HABIT-ILE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Doxorubicin|DRUG: Bleomycin|DRUG: Vinblastine|DRUG: Dacarbazine|DRUG: Vincristine|DRUG: Mechlorethamine|DRUG: Etoposide|DRUG: Prednisone|DRUG: Cyclophosphamide|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Refeeding Syndrome Among Older Adults
Status: COMPLETED
Conditions: Refeeding Syndrome
Interventions: DIETARY_SUPPLEMENT: Tubefeeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate Safety and Immunogenicity of DelNS1-nCoV-RBD LAIV for COVID-19
Status: UNKNOWN
Conditions: Covid19
Interventions: BIOLOGICAL: DelNS1-nCoV-RBD LAIV|BIOLOGICAL: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Risk Evaluation and Education for Alzheimer's Disease - the Study of Communicating Amyloid Neuroimaging (REVEAL-SCAN)
Status: COMPLETED
Conditions: Alzheimer Disease|Amyloid Beta-Peptides|Risk Assessment|Education|Neuropsychological Tests|Neuroimaging
Interventions: BEHAVIORAL: Alzheimer's Disease Risk Disclosure|BEHAVIORAL: Amyloid Brain Imaging and Alzheimer's Disease Risk Disclosure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prognosis Assessment of the Increase of GADD34 Gene Expression for Patient Suffering From Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Lupus Erythematosus
Interventions: OTHER: GADD34 RNA level measurement.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Effects of Domperidone on Cardiac Repolarization in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Treatment A (domperidone 10 mg)|DRUG: Treatment B (domperidone 20 mg)|DRUG: Treatment C (placebo)|DRUG: Treatment D (moxifloxacin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Whole-food, Plant-Based Nutrition Intervention in Women With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Breast Cancer Stage IV
Interventions: BEHAVIORAL: Plant-Based Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Induction Chemotherapy Combined With Neoadjuvant Immunotherapy for MSS Colon Cancer
Status: RECRUITING
Conditions: Colon Neoplasm
Interventions: DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Anti-PD-L1 Monoclonal Antibody|DRUG: Clostridium butyricum|PROCEDURE: Colectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Osteopathic Lymphatic Treatment on Plasma Volume, Protein Concentration and Albumin Concentration.
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: OLT maneuver|OTHER: Sham OLT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Study to Assess Efficacy, Safety of KAE609 in Adult Patients With Acute Malaria Mono-infection
Status: COMPLETED
Conditions: Cure Rate
Interventions: DRUG: KAE609|DRUG: KAE609|DRUG: KAE609|DRUG: KAE609
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VOLT-AF IDE Clinical Study
Status: RECRUITING
Conditions: Atrial Arrhythmia|Atrial Fibrillation|Paroxysmal Atrial Fibrillation|Persistent Atrial Fibrillation
Interventions: DEVICE: Pulsed Field Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Integrated Strategy to Support Antiretroviral Therapy and Pre-exposure Prophylaxis Adherence for HIV Prevention in Pregnant and Breastfeeding Women
Status: COMPLETED
Conditions: HIV-1-infection|Antenatal Care
Interventions: BEHAVIORAL: iNSC and Adherence supporter training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vibrotactile Coordinated Reset for the Treatment of Post Surgery Refractory Parkinson's Disease Patients
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: Vibrotactile Coordinated Reset (vCR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Lung Non-Small Cell Squamous Carcinoma|Metastatic Lung Non-Squamous Non-Small Cell Carcinoma|Stage IIIB Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8|Unresectable Lung Non-Small Cell Carcinoma|Unresectable Lung Non-Squamous Non-Small Cell Carcinoma
Interventions: DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Pevonedistat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of EVP-6308 to Assess the Dose- and Concentration-dependent Displacement of [18F]MNI-659 by EVP-6308
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: EVP-6308
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis- CloPidogREl for Primary preVENTION (HOST-PREVENTION)
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DRUG: Clopidogrel treatment group|OTHER: No antiplatelet or anticoagulant group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment of Oxidative Stress Markers in the Upper and Lower Airways of Atopic Children Treated With Nebulized Beclomethasone
Status: COMPLETED
Conditions: Asthma|Allergic Rhinitis
Interventions: DRUG: beclomethasone dipropionate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Suprascapular Radiofrequency Ablation in Hemiplegic Shoulder Pain
Status: NOT_YET_RECRUITING
Conditions: Hemiplegic Shoulder Pain
Interventions: PROCEDURE: Suprascapular nerve pulse radiofrequency ablation|PROCEDURE: Suprascapular Nerve Block Group|PROCEDURE: Steroid Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031 in Advanced Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: C-CAR031|DRUG: Lenvatinib|DRUG: PD-1(L1) monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Amithiozone (Thiacetazone) for Patients With Mycobacterium Avium Complex Pulmonary Disease
Status: COMPLETED
Conditions: Mycobacterium Avium-intracellulare Infection
Interventions: DRUG: amithiozone|DRUG: clarithromycin|DRUG: ethambutol|DRUG: rifampin|DRUG: streptomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Taurolidine Lock in Long Term Parenteral Nutrition
Status: COMPLETED
Conditions: Home Parenteral Nutrition|Central Venous Catheter
Interventions: DRUG: 2% Taurolidine Lock|DRUG: 1.35% Taurolidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Two Daily Disposable Lenses
Status: COMPLETED
Conditions: Refractive Ametropia|Myopia
Interventions: DEVICE: DACP FreshTech contact lenses|DEVICE: DACP contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intraoperative Dexmedetomidine on Postoperative Delirium in Elderly Patients Undergoing Robot-assisted Pancreaticoduodenectomy: a Randomized Controlled Study
Status: UNKNOWN
Conditions: Delirium in Old Age
Interventions: DRUG: Dexmedetomidine|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Subcutaneous Inj. Depot of Octreotide in Patients With Acromegaly and Neuroendocrine Tumours (NETs)
Status: COMPLETED
Conditions: Acromegaly|Neuroendocrine Tumors
Interventions: DRUG: octreotide FluidCrystal® injection depot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BiPAP for Cardiomyopathy With Central Sleep Apnea
Status: COMPLETED
Conditions: Dilated Cardiomyopathy
Interventions: DEVICE: bilevel positive airway pressure|DEVICE: bilevel positive airway pressure (Device)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerability, Safety, and Feasibility of Naloxegol in Patients With Cancer and OIC (Opioid Induced Constipation)
Status: TERMINATED
Conditions: Cancer|Constipation|Pain
Interventions: DRUG: Naloxegol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT