pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Phase 1/2 Study of CYT-0851 in B-Cell Malignancies and Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignancy|Non-hodgkin Lymphoma|Multiple Myeloma|Breast Cancer|Ovarian Cancer|Soft Tissue Sarcoma|Head and Neck Cancer|DLBCL|Mantle Cell Lymphoma|Follicular Lymphoma|Pancreatic Cancer|CLL|Small Cell Lung Cancer|Squamous Cell Carcinoma of Head and Neck|Triple Negative Breast Cancer
Interventions: DRUG: CYT-0851|DRUG: CYT-0851 in combination with gemcitabine|DRUG: CYT-0851 in combination with capecitabine|DRUG: CYT-0851 in combination with rituximab and bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug-drug Interaction (DDI) Study of Morphothiadine Mesilate/Ritonavir in Healthy Subjects
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: GLS4|DRUG: RTV|DRUG: ETV|DRUG: TDF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Pegylated Liposomal Doxorubicin and Cyclophosphamide in Her2-negative Stage I and II Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Epirubicin+Cyclophosphamide|DRUG: liposomal-doxorubicin+Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravenous S-ketamine on Opioid Consumption
Status: COMPLETED
Conditions: Breast Cancer Surgery
Interventions: DRUG: S-ketamine (low dose)|DRUG: Placebo|DRUG: S-ketamine (high dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-surgical Treatment of Peri-implantitis With and Without Erythritol Air-polishing
Status: COMPLETED
Conditions: Peri-Implantitis
Interventions: PROCEDURE: Titanium curette.|PROCEDURE: Ultrasonic|PROCEDURE: Air-polishing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy for the Treatment of Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Glioblastoma Multiforme|Glioblastoma|Malignant Glioma|Astrocytoma, Grade IV|GBM
Interventions: BIOLOGICAL: pp65-shLAMP DC with GM-CSF|BIOLOGICAL: unpulsed PBMC and saline|DRUG: Td|DRUG: Saline|BIOLOGICAL: pp65-flLAMP DC with GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Open Label Study to Examine the Effects of a High-Fat Meal and Particle Size on the Pharmacokinetics of Orally Administered GSK2118436 in Subjects With BRAF Mutation Positive Tumor
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Regimen A|DRUG: Regimen B|DRUG: Regimen C|DRUG: Regimen D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Radiobiological Effects in Skin Toxicities Head and Neck Cancer Patients With PBS Proton Therapy
Status: RECRUITING
Conditions: Head and Neck Cancer|Head and Neck Squamous Cell Carcinoma|Head and Neck Carcinoma
Interventions: RADIATION: Spot Delete
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Beneficial Effect of Probiotics on Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DIETARY_SUPPLEMENT: Probiotics|DIETARY_SUPPLEMENT: Cornstarch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fluoro-L-Thymidine Positron Emission Tomography (FLT PET) vs. Adv. Magnetic Resonance (MR) Techniques in Recurrent Glioma
Status: WITHDRAWN
Conditions: Brain Tumor
Interventions: PROCEDURE: PET Scan|DRUG: 3'-Deoxy-3'-18f-Fluorothymidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ELIGIBLE (Efficacy of Left atrIal Appendage Closure After GastroIntestinal BLEeding)
Status: UNKNOWN
Conditions: Adverse Reaction to Drugs Affecting the Gastrointestinal System
Interventions: DEVICE: Left atrial appendage occlusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality (VR) to Improve Quality of Life in Patients Diagnosed With Neurological Disorders
Status: COMPLETED
Conditions: Multiple Sclerosis|Chronic Pain|Neurological Disorder
Interventions: DEVICE: HTC Vive Virtual Reality (VR) system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Response of Injectafer vs Oral Iron to Baseline Hepcidin Levels in Patients With Iron Deficiency Anemia (IDA) Secondary to Inflammatory Bowel Disease (IBD) or Gastric Bypass
Status: COMPLETED
Conditions: Iron Deficiency Anemia Secondary to IBD or Gastric Bypass
Interventions: DRUG: Injectafer|DRUG: Ferrous Sulfate tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Pentoxifylline on Tight Junctions (TJs) of Intestinal Mucosa in Patients With Irritable Bowel Syndrome(IBS)
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: pentoxifylline|DRUG: pentoxifylline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Decision-Making Encounters in Lung Cancer Using a Low-Literacy Conversation Tool
Status: RECRUITING
Conditions: Lung Carcinoma
Interventions: OTHER: Best Practice|OTHER: Health Promotion and Education|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of HSP90 Inhibitor AT13387 Alone or in Combination With Abiraterone Acetate
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: AT13387|DRUG: abiraterone acetate|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of the Kinetics of Renal Glucose Reabsorption in Response to Dapagliflozin in Healthy Subjects and in Subjects With Type 2 Diabetes Mellitus (T2DM)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Fully Blocking Type 1 Angiotensin Receptor on Target Organ Damage of Postmenopausal Hypertensive Women
Status: UNKNOWN
Conditions: Hypertension
Interventions: DRUG: Valsartan 1|DRUG: Valsartan 80 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Question Prompt List for Orthopaedic Conditions
Status: COMPLETED
Conditions: Tendon Injuries|Fracture|Arthritis|Sprains|Strains|Tumor|Pain
Interventions: OTHER: Question Prompt List|OTHER: 3 questions list
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Outpatient Yoga Study for Adolescents Receiving Chemotherapy
Status: COMPLETED
Conditions: Pediatric Cancer|Quality of Life|Cancer, Treatment-Related|Psychological Distress|Yoga|Feasibility
Interventions: OTHER: Yoga Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: In Vitro Basophil Responsiveness to Allergen Challenge After Gamma-tocopherol Supplementation in Allergic Asthmatics
Status: COMPLETED
Conditions: Allergic|Asthmatic|Allergy|Asthma
Interventions: DIETARY_SUPPLEMENT: gamma-tocopherol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Obinutuzumab Versus Rituximab in Childhood Steroid Dependant and Frequent Relapsing Nephrotic Syndrome
Status: RECRUITING
Conditions: Steroid-Dependent Nephrotic Syndrome|Steroid-Sensitive Nephrotic Syndrome
Interventions: DRUG: single infusion of Rituximab|DRUG: single infusion of Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of 4L Polyethylene Glycol and 2L Polyethylene Glycol With Ascorbic Acid in Inactive UC Patients
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: polyethylene glycol|DRUG: Ascorbic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Combining Accelerometer, Gyroscope, Sound, Electrocardiography and Photoplethysmography Data in Cardiac Monitoring
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: FibriCheck recordings
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Rivaroxaban for Treatment of Patients With Suspected or Confirmed Heparin-Induced Thrombocytopenia
Status: TERMINATED
Conditions: Heparin-induced Thrombocytopenia
Interventions: DRUG: Rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ERAdicate S. Aureus in Patients With Bacteremia and Endocarditis
Status: WITHDRAWN
Conditions: Bacteremia Due to Staphylococcus Aureus|Left Sided Infective Endocarditis (Disorder)|Right Sided Infective Endocarditis (Disorder)|Endocarditis Infective
Interventions: DRUG: Tonabacase (LSVT-1701)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The FDR (Femoral Derotaton) Trail.
Status: RECRUITING
Conditions: Idiopathic Increased Femoral Anteversion
Interventions: DEVICE: Adolescent Lateral Entry Femoral Nail|DEVICE: Pediatric LCP Hip Plate System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Diet in Periodontal Inflammation: A Controlled Clinical Study
Status: RECRUITING
Conditions: Periodontal Inflammation|Periodontal Diseases
Interventions: DIETARY_SUPPLEMENT: Vegan/vegetarian diet|DIETARY_SUPPLEMENT: Omnivorous diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ibuprofen in Migraine Patients
Status: COMPLETED
Conditions: Migraine Without Aura
Interventions: DRUG: Ibuprofen 400 mg|DRUG: Dexketoprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Micro-Layer Ablation of Barrett's Metaplasia- A Two-Phase, Multi-Center Trial - Extension of Follow-up to 5 Years
Status: COMPLETED
Conditions: Barrett Esophagus
Interventions: DEVICE: HALO Ablation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: C14 Study in Oncology Patients With Advanced and/or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DRUG: LY2603618|DRUG: Pemetrexed|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atorvastatin Efficacy and Safety in Patients With Ulcerative Colitis
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases
Interventions: DRUG: Atorvastatin 80mg|DRUG: Mesalamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Fluids and Catheters Treatment Trial (FACTT) - ARDS Clinical Research Network
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome|Lung Diseases
Interventions: PROCEDURE: pulmonary artery catheter|PROCEDURE: central venous catheter|PROCEDURE: fluid management
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: FACTORIAL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Desvenlafaxine vs. Placebo Treatment of Chronic Depression
Status: COMPLETED
Conditions: Dysthymic Disorder|Dysthymia|Chronic Depressive Disorder
Interventions: DRUG: Desvenlafaxine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy and Safety of Dose Conversion From a Long-acting Erythropoiesis-stimulating Agent (Mircera®) to Three Times Weekly Oral Vadadustat for the Maintenance Treatment of Anemia in Hemodialysis Subjects
Status: COMPLETED
Conditions: Anemia Associated With Chronic Kidney Disease (CKD)
Interventions: DRUG: Vadadustat|DRUG: Mircera®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Corin MiniHip and Trinity Cup Clinical Surveillance Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Total Hip Arthroplasty|Osteoarthritis, Hip|Traumatic Arthritis of Hip|Rheumatoid Arthritis of Hip|Developmental Dysplasia of the Hip|Avascular Necrosis of the Femoral Head
Interventions: DEVICE: MiniHip Stem|DEVICE: Trinity Acetabular Cup System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multi-Nutrient Supplement for Radio-Protection
Status: NOT_YET_RECRUITING
Conditions: Oxidative Stress|DNA Damage, Radiation Induced|Radiation Exposure
Interventions: DRUG: Multi-nutrient supplement|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Human MesenchymAl Stem Cells Infusion in Patients With Cystic Fibrosis
Status: WITHDRAWN
Conditions: Cystic Fibrosis
Interventions: BIOLOGICAL: Allo-hMSCs|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: rTMS for the Treatment of Affective Symptoms in Patients Suffering From Dementia
Status: UNKNOWN
Conditions: Behavioral and Psychiatric Symptoms of Dementia
Interventions: DEVICE: rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of CDP870/Certolizumab Pegol in Patients With Active Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: Certolizumab Pegol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Examine the Effect of Betahistine on Body Weight Gain Due to Olanzapine Treatment
Status: TERMINATED
Conditions: Weight Gain
Interventions: DRUG: Betahistine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Association Between Blood Volume, the Interval From Delivery to Cord Clamping, and Number of Umbilical Cord Milking
Status: COMPLETED
Conditions: Pregnancy Related|Umbilical Cord Issue|Placental Transfusion
Interventions: PROCEDURE: cord blood spontaneous drainage|PROCEDURE: Umbilical cord miking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Pharmacokinetics of Regorafenib and Cetuximab in Combination
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Regorafenib (Stivarga, BAY73-4506)|DRUG: Cetuximab (ERBITUX)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy and Real-Time Pain Management Intervention for Sickle Cell Via Mobile Applications
Status: COMPLETED
Conditions: Chronic Pain|Depression, Anxiety|Opioid Use
Interventions: OTHER: cCBT|OTHER: m-Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Epidemiological Features of Emergent Highly Resistant Bacteria in Tunisian Intensive Care Units
Status: RECRUITING
Conditions: Cross Infection|Carbapenem Resistant Bacterial Infection|Vancomycin-Resistant Enterococcal Infection|Critical Illness
Interventions: OTHER: epidemiological records
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Outcomes and Healthcare Economics of SOLTIVE Compared to Ho:YAG Laser in Urolithiasis
Status: RECRUITING
Conditions: Kidney Stone
Interventions: DEVICE: SOLTIVE Thulium Fiber Laser|DEVICE: Ho:YAG Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy (Bronchoprotection) and Safety of Orally Inhaled BI 1744 CL in Patients With Intermittent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Placebo|DRUG: Olodaterol (BI1744CL)|DRUG: Olodaterol (BI1744CL)|DRUG: Olodaterol (BI1744CL)|DRUG: Olodaterol (BI1744CL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Trametinib + Ceritinib in Patients With Unresectable Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma|Unresectable Melanoma|Advanced Melanoma
Interventions: DRUG: Ceritinib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EAGLE - Multicenter Study of the European Assessment Group for Lysis in the Eye
Status: TERMINATED
Conditions: Retinal Artery Occlusion|Fibrinolysis|Visual Acuity|Stroke|Hemodilution
Interventions: DRUG: Intravenous injection of heparin|DRUG: Intravenous injection of acetazolamide|PROCEDURE: Local intra-arterial fibrinolysis|PROCEDURE: Globe massage|DRUG: Topical use of beta-blocker|DRUG: Isovolaemic haemodilution|DRUG: Acetylsalicylic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Analgesic Effect of Transversus Abdominis Plane (TAP) Block Following Radical Prostatectomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Naropine|DRUG: Naropine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics (PK) of 20 mg Teduglutide in Participants With Moderately Impaired Hepatic Function Compared to Healthy Participants
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: Teduglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety of Sildenafil in Premature Infants
Status: RECRUITING
Conditions: Bronchopulmonary Dysplasia
Interventions: DRUG: Sildenafil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electroacupuncture for the Prevention of Chemotherapy-induced Nausea and Vomiting in Patients With Breast Cancer
Status: RECRUITING
Conditions: Electroacupuncture|Olanzapine-contained Four-drug Antiemetic|Nausea and Vomiting
Interventions: DEVICE: Electroacupuncture|DRUG: Standard antiemetic treatment|DEVICE: Sham electroacupuncture|DRUG: Standard antiemetic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Life Goals Collaborative Care to Improve Health Outcomes in Mental Disorders
Status: COMPLETED
Conditions: Bipolar Disorder|Schizophrenia|Major Depressive Disorder|Schizoaffective Disorder|Cardiovascular Disease Risk
Interventions: BEHAVIORAL: Life Goals Collaborative Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pilot Implementation of HIV Self-testing Delivery in Private Pharmacies Combined to a Respondent Driven Sampling Method to Improve HIV Testing for MSM and TGW in Phnom Penh - ANRS 0100s
Status: NOT_YET_RECRUITING
Conditions: HIV Infections
Interventions: DIAGNOSTIC_TEST: OraQuick
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Fotemustine(FTM) Vs FTM and Ipilimumab (IPI) or IPI and Nivolumab in Melanoma Brain Metastasis
Status: UNKNOWN
Conditions: Brain Metastases
Interventions: DRUG: Fotemustine|DRUG: Fotemustine and Ipilimumab|DRUG: Ipilimumab and nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studying Biopsy Samples in Women Undergoing First-Line Chemotherapy for Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: chemotherapy|GENETIC: gene expression analysis|OTHER: laboratory biomarker analysis|PROCEDURE: breast biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Carbamazepine and Oxcarbazepine on Serum Neuron-specific Enolase and S100B in Focal Seizures
Status: COMPLETED
Conditions: Seizures, Focal
Interventions: DRUG: Carbamazepine|DRUG: Oxcarbazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Aprepitant in Subjects With Multiple Myeloma During and After High-dose Chemotherapy
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Emend|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Supramaximal Rectus Recession for Strabismus in Grave's Ophthalmopathy
Status: UNKNOWN
Conditions: Strabismus, Mechanical|Graves Ophthalmopathy
Interventions: PROCEDURE: supramaximal rectus recession|PROCEDURE: normal rectus recession
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dermatological Evaluation of Topic Compatibility-Dermacyd Tina Gel Sweet Flower
Status: COMPLETED
Conditions: Hygiene
Interventions: DRUG: Lactic acid (Dermacid)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study of Huaier Granule in the Treatment of Unresectable Pancreatic Cancer
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Cancer Non-resectable
Interventions: DRUG: Huaier Granule|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Study the Safety and Effectiveness of a Granisetron Patch to Treat Chemotherapy-Induced Nausea and Vomiting (CINV)
Status: COMPLETED
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: DRUG: Granisetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Rituximab Treatment for Idiopathic Membranous Nephropathy
Status: COMPLETED
Conditions: Idiopathic Membranous Nephropathy
Interventions: DRUG: symptomatic treatment (Converting Enzyme inhibitor, Angiotensin II, Anti-renin, Aldosterone antagonist diuretic, Beta blocker, Calcium inhibitor, statin)|DRUG: experimental (Non Immunosuppressive Symptomatic Treatment (NIST) and Rituximab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Coffee/Caffeine Improve Post-Operative Gastrointestinal Recovery
Status: ACTIVE_NOT_RECRUITING
Conditions: Postoperative Ileus|Caffeine
Interventions: OTHER: Coffee|OTHER: Decaffeinated Coffee|OTHER: Warm water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogenic Transplantation of Ex-vivo Expanded Cord Blood (CB)
Status: WITHDRAWN
Conditions: Umbilical Cord Blood|Stem Cell Transplantation|Hematological Malignancies
Interventions: BIOLOGICAL: ex vivo expansion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plating Clavicle Fractures
Status: UNKNOWN
Conditions: Clavicle Fracture, Non Union/Malunion
Interventions: PROCEDURE: superior plate|PROCEDURE: anterior-inferior plate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Encorafenib, Binimetinib and Palbociclib in BRAF-mutant Metastatic Melanoma CELEBRATE
Status: RECRUITING
Conditions: Melanoma|Metastasis
Interventions: DRUG: Binimetinib|DRUG: Encorafenib|DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AbsorbaTack Evaluation of Postoperative Pain Following Laparoscopic Hernia Repair
Status: COMPLETED
Conditions: Hernia, Inguinal|Hernia, Ventral
Interventions: DEVICE: AbsorbaTack|DEVICE: ProTack
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase-2 Dacomitinib Study on Patients With EGFR-Driven Advanced Solid Tumours With Low EGFR-AS1 IncRNA Expr or Other Novel Emerging Biomarkers
Status: RECRUITING
Conditions: Advanced Solid Tumours|Non-small Cell Lung Cancer|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Oral Dacomitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safer Conception Intervention for HIV-1 Serodiscordant Couples
Status: COMPLETED
Conditions: HIV Seropositivity|Pregnancy, High-Risk
Interventions: DRUG: PrEP|BEHAVIORAL: Counseling on timed condomless sex, ART and PrEP adherence
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Analysis of Cytokines in Response to Treatment of Diabetic Macular Edema With 0.3mg Lucentis
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Lucentis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Using Transcranial Magnetic Stimulation (TMS) to Understand 'Negative' Symptoms of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Negative Type; Schizophrenic|Schizo Affective Disorder
Interventions: DEVICE: repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: HIPEC Combined With Camrelizumab, Paclitaxel and S-1 for Conversion Therapy in Patients With Advanced Gastric Cancer With Peritoneal Metastasis
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer, HIPEC, Anti-PD-1 Antibody Camrelizumab (SHR-1210), Chemotherapy and Surgery
Interventions: DRUG: HIPEC, anti-PD-1 antibody Camrelizumab (SHR-1210), Chemotherapy and Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Bone Fixation Plate for the Repair of Tibial Avulsion Fracture of Posterior Cruciate Ligament of the Knee
Status: COMPLETED
Conditions: Tibial Fractures
Interventions: DEVICE: new bone fixation plate with screw
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PAXG Out in the Country
Status: RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: PAXG regimen (cisplatin, nab-paclitaxel, capecitabine, gemcitabine) chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Modern Colon Hydrotherapy on Intestinal Transit
Status: NOT_YET_RECRUITING
Conditions: Constipation - Functional|Hydrotherapy|Functional Colonic Diseases
Interventions: OTHER: Modern Colon Hydrotherapy plus probiotic product intake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ponatinib - Frontline for Chronic Myeloid Leukemia (CML) in Accelerated Phase (AP)
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: Ponatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prediction of Occult Peritoneal Metastasis of Locally Advanced Gastric Cancer Using Multimodal Data Based on Artificial Intelligence Combined With Intraoperative Dynamic Video
Status: NOT_YET_RECRUITING
Conditions: This Study Uses AI and Multimodal Data to Noninvasively Detect Occult Peritoneal Metastasis
Interventions: DIAGNOSTIC_TEST: Laparoscopic exploration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Digital Colposcopy in Finding Cervical Intraepithelial Neoplasia
Status: COMPLETED
Conditions: Cervical Cancer|Precancerous Condition
Interventions: OTHER: histological technique|OTHER: laboratory biomarker analysis|PROCEDURE: colposcopic biopsy|PROCEDURE: colposcopy|PROCEDURE: light-scattering spectroscopy|PROCEDURE: loop electrosurgical excision procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Extended Half Life Factor (EHF) Products For Heavy Menstrual Bleeding in Hemophilia Carriers
Status: COMPLETED
Conditions: Hemophilia|Menstrual Flow Excessive
Interventions: DRUG: Recombinant FVIII Fc fusion product Eloctate|DRUG: Recombinant FIX Fc fusion product Alprolix|DEVICE: Patient-operated diagnostic device for anemia AnemoCheck.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Map the HLA Genomic Region in the Greek Population
Status: RECRUITING
Conditions: Healthy|Respiratory Disease|Chronic Renal Failure|Cardiovascular Diseases|Metabolic Disease|Psychiatric Disorder|Neurologic Disorder|Gastrointestinal Diseases|Haematologic Disease|Rheumatologic Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Study Comparing PillCam® Crohn's Capsule Endoscopy to Ileocolonoscopy (IC) Plus MRE for Detection of Active CD in the Small Bowel and Colon in Subjects With Known CD and Mucosal Disease.
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DEVICE: Capsule Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The (Cost-) Effectiveness of Mindfulness-training and Cognitive Behavioural Therapy in Adolescents and Young Adults With Deliberate Self Harm
Status: UNKNOWN
Conditions: Self-Injurious Behavior
Interventions: BEHAVIORAL: Cognitive Behavioral treatment|BEHAVIORAL: Mindfulness based cognitive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis
Status: COMPLETED
Conditions: Aphthous Stomatitis
Interventions: DRUG: Ibuprofen, Diphenhydramine and Aluminium MgS|DRUG: Diphenhydramine and Aluminium MgS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Acute Myeloid Leukemia in Second Remission
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: filgrastim|DRUG: busulfan|DRUG: cytarabine|DRUG: etoposide|DRUG: methotrexate|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD8+ Memory T-Cells as Consolidative Therapy After Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients With Leukemia or Lymphoma
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|B-Cell Non-Hodgkin Lymphoma|Chronic Lymphocytic Leukemia|Hodgkin Lymphoma|Myelodysplastic Syndrome|Myeloproliferative Neoplasm|T-Cell Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: Anti-Thymocyte Globulin|DRUG: Cyclosporine|DRUG: Mycophenolate Mofetil|PROCEDURE: Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplant|BIOLOGICAL: Allogeneic Cluster of Differentiation 8 (CD8)+ Memory T-cells|RADIATION: Total Nodal Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Escalation Study of LY573636-sodium and Liposomal Doxorubicin in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: LY573636-sodium|DRUG: Liposomal Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Antiplatelet and Antioxidant Agents on Drusen Progression: A Pilot, Prospective Cohort Study
Status: RECRUITING
Conditions: Dry Age-related Macular Degeneration
Interventions: DRUG: Aspirin 81Mg Ec Tab|DRUG: Clopidogrel|DRUG: N-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Patient Acceptance And Satisfaction of Teledermoscopy In General Practice In a Belgian Rural Area
Status: UNKNOWN
Conditions: Skin Cancer|Patient Acceptance of Health Care|Patient Satisfaction
Interventions: OTHER: taking macroscopic and dermoscopic pictures of suspicious skin lesions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Strict Classic Ketogenic Diet as a Therapy for Recurrent or Progressive and Refractory Brain Tumors in Children
Status: WITHDRAWN
Conditions: Recurrent Brain Tumor, Childhood|Ketogenic Diet
Interventions: OTHER: Strict Classic Ketogenic Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genital Hygiene Training Provided to Turkish Women
Status: COMPLETED
Conditions: Genital Hygiene|Genital Hygiene Behaviors|Self-care Agency
Interventions: OTHER: Genital hygiene training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Investigate the Effect of an Oral Diamine Oxidase Substitution (DAOsin) in Histamine Intolerant Patients on the Low Endogenous Diamine Oxidase Serum Activity
Status: COMPLETED
Conditions: Food Intolerance|Histamine Intolerance
Interventions: DIETARY_SUPPLEMENT: DAOsin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetuximab and Stereotactic Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: cetuximab|RADIATION: stereotactic body radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Red Blood Cell Distributions (RDW, RDW-CW) and Lymphocyte Monocyte Ratios (LMR) for the Malignant Thyroid Nodules
Status: COMPLETED
Conditions: Thyroid Neoplasms Benign|Thyroid Nodule|Thyroid Cancer|Thyroid Diseases
Interventions: PROCEDURE: Thyroidectomy, Bilaterally Total|PROCEDURE: Thyroidectomy, Unilaterally Total|PROCEDURE: Thyroidectomy, Complementary|PROCEDURE: Thyroidectomy, Near Total
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chloroquine + Losartan Compared to Chloroquine Alone for the Treatment of COVID-19 Pneumonia
Status: WITHDRAWN
Conditions: COVID-19 Pneumonia
Interventions: DRUG: Chloroquine Phosphate Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Application of Combined Lumbar Plexus and Sciatic Nerve Block
Status: COMPLETED
Conditions: Anesthesia
Interventions: PROCEDURE: Nerve block|PROCEDURE: Combined spinal and epidural anesthesia|DRUG: Ropivacaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbial Transplant in Pediatric Crohn's Disease
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: Fecal Microbial transplant|DRUG: Normal Saline|DRUG: rifaximin+omeprazole+miralax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Inspiratory Muscle Training on Exertional Breathlessness in Patients With Unilateral Diaphragm Paralysis
Status: COMPLETED
Conditions: Diaphragmatic Paralysis
Interventions: PROCEDURE: Strength inspiratory muscle training|PROCEDURE: Endurance inspiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: FATLAS: Comprehensive Multi-level Characterization of Systemic and Mammary Adiposity in Breast Cancer Patients.
Status: RECRUITING
Conditions: Breast Neoplasms
Interventions: OTHER: Prospective data and sample collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Internet Therapeutic Intervention on A1C Levels in Type 2 Diabetes Mellitus (DM) on Monotherapy
Status: SUSPENDED
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: Internet Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of NAVA Ventilation on Brain Oxygenation and Perfusion in Children With Congenital Heart Disease
Status: RECRUITING
Conditions: Tetralogy of Fallot|Hypoplastic Left Heart Syndrome|Univentricular Heart|Heart Defects, Congenital
Interventions: OTHER: Neurally adjusted ventilatory assist first|OTHER: Conventional ventilation first
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluating Myelodysplastic Syndrome Risks in NET Patients Planned for Peptide Radionuclide Therapy
Status: NOT_YET_RECRUITING
Conditions: Myelodysplastic Syndrome|Acute Myeloid Leukemia
Interventions: RADIATION: Peptide receptor radionuclide therapy (PRRT)|DIAGNOSTIC_TEST: Blood collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: High Refractive Index Material 510(k)
Status: COMPLETED
Conditions: Myopia|Hyperopia
Interventions: OTHER: HDS HI 1.54; pahrifocon A|DEVICE: FluoroPerm 30 RGP; paflufocon C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Increasing Atrial Base Rate Pacing to Reduce Atrial Fibrillation
Status: COMPLETED
Conditions: Sick Sinus Syndrome|Paroxysmal Atrial Fibrillation
Interventions: DEVICE: HBR|DEVICE: DD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Personalised Exercise Training in Adolescents With Type 2 Diabetes for the Early Prevention of Beta Cell Dysfunction
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes
Interventions: OTHER: aerobic exercise|OTHER: high-intensity interval exercise training|OTHER: resistance exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy, Radiation Therapy and Immunotherapy Prior to Surgery in Operable Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: Erlotinib|DRUG: Bevacizumab|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: 5-FU|PROCEDURE: Radiation therapy|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Unlock the Cell: Castleman's Disease Flow Cytometry Study
Status: COMPLETED
Conditions: Castleman Disease|Angiofollicular Lymphoid Hyperplasia|GLNH|Hyperplasia|Castleman's Disease|Angiofollicular Lymph Hyperplasia|Giant Lymph Node Hyperplasia
Interventions: PROCEDURE: Blood draw/buccal swab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: COLLISION XL: Unresectable Colorectal Liver Metastases (3-5cm): Stereotactic Body Radiotherapy vs. Microwave Ablation
Status: RECRUITING
Conditions: Colorectal Cancer Metastatic|Liver Metastasis Colon Cancer
Interventions: DEVICE: Stereotactic Body Radiotherapy|DEVICE: Microwave Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Wound Vacuum Dressing and Standard Closure to Reduce Rates of Surgical Site Infections
Status: COMPLETED
Conditions: Surgical Site Infection|Pancreatic Neoplasms|Pancreatic Cancer|Chemotherapy Effects|Chemoradiation|Surgical Wound|Wound Complication
Interventions: DEVICE: Prevena Peel & Place Dressing|OTHER: Standard Closure of the Surgical Incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Assess Pharmacokinetic Drug-Drug Interaction Between Avatrombopag When Co-Administered With Fluconazole, Itraconazole, or Rifampin in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Avatrombopag|DRUG: Fluconazole|DRUG: Itraconazole|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Veregen ™ 15% Ointment Treatment For Non-facial Verrucae in Pediatric Patients: A Pilot Study
Status: COMPLETED
Conditions: Verruca, Warts
Interventions: DRUG: Veregen only|PROCEDURE: Cryotherapy and Veregen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Preoperative Misoprostol in Blood-loss Reduction During Myomectomy.
Status: UNKNOWN
Conditions: Uterine Fibroid
Interventions: DRUG: Misoprostol Pfizer Brand|OTHER: Non-insertion of Misoprostol Pfizer Brand
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the 2-year Clinical Performances of Class II Restorations Using Different Restorative Materials
Status: COMPLETED
Conditions: Dental Caries Class II
Interventions: OTHER: Bulk-fill Composite Resin|OTHER: Traditional Posterior Composite Resin|OTHER: High-filler Flowable Composite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of SHR0410 Injection in Hemodialysis Participants.
Status: COMPLETED
Conditions: Pruritus
Interventions: DRUG: SHR0410|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prediction of Response to Intra-articular Injections of Hyaluronic Acid for Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: hylan G-F 20|DEVICE: 1% sodium hyaluronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Single-dose Study of [14C]Lorlatinib (PF-06463922) Metabolism In Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: [14C]lorlatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of (-)-Epicatechin in the Treatment of Becker Muscular Dystrophy (Pilot Study)
Status: COMPLETED
Conditions: Becker Muscular Dystrophy
Interventions: DRUG: (-)-epicatechin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT