pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Feasibility of Insomnia Tracking and Treatment in IBD
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|Insomnia
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia (CBT-I)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Cardiac Magnetic Resonance Imaging (MRI) Versus Cardiac Catheterization Prior to Glenn Operation
Status: COMPLETED
Conditions: Congenital Heart Defects
Interventions: PROCEDURE: Diagnostic cardiac MRI|PROCEDURE: Cardiac catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Role of Circuit Flow During Mechanical Ventilation of Neonates
Status: COMPLETED
Conditions: Respiratory Distress Syndrome in Premature Infant
Interventions: DEVICE: SIPPV_VG_0_08|DEVICE: SIPPV_VG_0_16|DEVICE: SIPPV_VG_0_24|DEVICE: SIPPV_VG_0_32|DEVICE: SIPPV_VG_0_40|DEVICE: PSV_VG_0_08|DEVICE: PSV_VG_0_16|DEVICE: PSV_VG_0_24|DEVICE: PSV_VG_0_32|DEVICE: PSV_VG_0_40
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fascia Iliaca Compartment Block for Pain Management in Hip Fracture Patients
Status: COMPLETED
Conditions: Hip Fractures
Interventions: PROCEDURE: fascia iliaca compartment block, (FICB) (levobupivacaine hydrochloride 0,25% 40 ml)|DRUG: paracetamol 1 gram IV|DRUG: Rescue analgesic tramadol 100 mg IV if needed|PROCEDURE: Sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Followed By Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Refractory AIDS-Related Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|DRUG: busulfan|DRUG: cyclophosphamide|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Pharmacokinetic Effect of Itraconazole on SHR0302 Tablets in Healthy Subjects
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: itraconazole、 SHR0302 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of BacT/Alert® VIRTUO®, BioFire® Blood Culture Identification 2-BCID2 and REVEAL® (bioMérieux) on the Optimization of Antibiotic Therapy for Gram-negative Bacteremia in the ICU
Status: RECRUITING
Conditions: Bacteremia
Interventions: DIAGNOSTIC_TEST: Innovative diagnostic technologies|DIAGNOSTIC_TEST: Reference diagnostic technique
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the Effectiveness and Safety of Desloratadine (Aerius) Syrup in Children With Hayfever With or Without Asthma (P03472)
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal|Asthma
Interventions: DRUG: Desloratadine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nitazoxanide Plus Lactulose Versus Lactulose Alone Treatment of Hepatic Encephalopathy
Status: UNKNOWN
Conditions: Encephalopathy, Hepatic
Interventions: DRUG: Nitazoxanide|DRUG: Lactulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Studying Tissue and Blood Samples From Patients With Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia
Interventions: GENETIC: DNA analysis|GENETIC: DNA methylation analysis|GENETIC: gene expression analysis|GENETIC: mutation analysis|GENETIC: polymerase chain reaction|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: high performance liquid chromatography|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Using PET-CT to Target and Validate Low-frequency TMS as Treatment for Tinnitus
Status: COMPLETED
Conditions: Tinnitus
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Topical Rebamipide Versus Topical Betamethasone for Management of Oral Ulcers in Behcet's Disease
Status: NOT_YET_RECRUITING
Conditions: Oral Ulceration Due to Behçet's Disease
Interventions: DRUG: Rebamipide mouthwash|DRUG: Betamethasone mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Trial of High Dose vs. Standard Dose Vit D2 With Docetaxel in Met Breast ca
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel + High dose Vitamin D2|DRUG: Docetaxel + Standard dose Vitamin D2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Investigate the Efficacy of Treatment With Gemcitabine/Pazopanib in Patients With Biliary Tree Cancer
Status: TERMINATED
Conditions: Cholangiocarcinoma|Gallbladder Carcinoma|Biliary Carcinoma
Interventions: DRUG: Gemcitabine-Pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intranasal Ketamine as a Sedative for Venipuncture
Status: COMPLETED
Conditions: Respiratory Tract Disease|Acute Pain|Diseases of the Digestive System
Interventions: DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GUM Hydral Mouthwash vs Placebo in the Management of Hyposalivation.
Status: COMPLETED
Conditions: Xerostomia|Xerostomia Following Radiotherapy
Interventions: DEVICE: Hydral|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SARS-CoV-2 Vaccine (GEO-CM04S1) Versus mRNA SARS-COV-2 Vaccine in Patients With Blood Cancer
Status: RECRUITING
Conditions: COVID-19 Infection|Hematopoietic and Lymphoid System Neoplasm|Leukemia|Lymphoma|Plasma Cell Myeloma
Interventions: BIOLOGICAL: COVID-19 Vaccine|OTHER: Diagnostic Laboratory Biomarker Analysis|BIOLOGICAL: Synthetic MVA-based SARS-CoV-2 Vaccine GEO-CM04S1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Training Combined With Transcranial Direct Current Stimulation in Older Adults in a Home-based Context
Status: COMPLETED
Conditions: Aging
Interventions: DEVICE: Anodal tDCS|BEHAVIORAL: Intensive cognitive training|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Executive Function and Emotional Regulation in Children in Bangladesh
Status: RECRUITING
Conditions: Executive Function Disorder|Emotional Regulation|Malnutrition, Child
Interventions: DIETARY_SUPPLEMENT: Chickpea based RUSF|DIETARY_SUPPLEMENT: E-RUSF|DIETARY_SUPPLEMENT: Outcome reference group/RUSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Newborn|Respiratory Failure
Interventions: DRUG: Poractant alfa instillation|DRUG: Beractant instillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enzastaurin in Treating Young Patients With Refractory Primary CNS Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Neuroblastoma
Interventions: DRUG: enzastaurin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reconstruction Techniques and Vascular Approach After Laparoscopic Left Hemicolectomy and Rectum Low Anterior Resection
Status: COMPLETED
Conditions: Colorectal Cancer|Rectal Tumors
Interventions: PROCEDURE: Initially dissection of inferior mesenteric vein|PROCEDURE: Initially dissection of inferior mesenteric artery|PROCEDURE: Latero-terminal colorectal anastomosis|PROCEDURE: Termino-terminal colorectal anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evealuate Safety and Immunogenicity of TI-0010 SARS-CoV-2 Vaccine in Healthy Adults
Status: RECRUITING
Conditions: COVID-19|COVID-19 Immunisation
Interventions: BIOLOGICAL: TI-0010|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Exploratory Study of Additional Use of Scopolamine Butylbromide, Glucagon or NPO-11 Following Single Dose of NPO-11 in Healthy Adult Men
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: NPO-11|DRUG: NPO-11|DRUG: NPO-11
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fimasartan Achieving SBP Target (FAST) Study
Status: COMPLETED
Conditions: Essential,Hypertension
Interventions: DRUG: Placebo|DRUG: Fimasartan|DRUG: Valsartan|DRUG: Olmesartan medoxomil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Phase II Study of Hepatitis C Immune Globulin Intravenous (Human), Civacir(TM), in Liver Transplantation
Status: TERMINATED
Conditions: Sequelae of Viral Hepatitis|Transplantation Infection|Evidence of Liver Transplantation
Interventions: BIOLOGICAL: Hepatitis C Immune Globulin Intravenous (Human) 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alprazolam Extended-Release 3mg Tablets Bioequivalence Study Under Non-fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Alprazolam Extended-Release 3 mg Tablets|DRUG: Alprazolam Extended-Release 3 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: In Vivo Study of Interactions Between the Endocannabinoid System and the Corticotropic Axis in Man
Status: COMPLETED
Conditions: Cushing's Syndrome
Interventions: OTHER: Obese|PROCEDURE: Hypercortisolism|OTHER: Hydrocortisone|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety Study of Ambrisentan in Chinese Patients With Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Ambrisentan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carboplatin, Pemetrexed Disodium, and Bevacizumab for Patients With Stage III or IV Non-Small Cell Lung Cancer Who Are Light/Never Smokers
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: carboplatin|DRUG: erlotinib hydrochloride|DRUG: pemetrexed disodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension Study of ECU-MG-301 to Evaluate Safety and Efficacy of Eculizumab in Refractory Generalized Myasthenia Gravis
Status: COMPLETED
Conditions: Refractory Generalized Myasthenia Gravis
Interventions: BIOLOGICAL: Eculizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ITI 333 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: ITI-333|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Motion Serifos: A Study to Investigate the Efficacy of Tradipitant in Participants Affected by Motion Sickness
Status: RECRUITING
Conditions: Motion Sickness
Interventions: DRUG: Tradipitant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of HCP1305 and Co-administration of HCP0605, HGP0816 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HCP0605 + HGP0816|DRUG: HCP1305
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Nasal Spray on Viral Respiratory Infections
Status: RECRUITING
Conditions: Acute Respiratory Tract Infection|Flu, Human|COVID-19|Common Cold
Interventions: DEVICE: Nasal Spray HSV Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of OROS® Oxybutynin Chloride for the Treatment of Urge Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: DRUG: OROS® oxybutynin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of IGN-ES001 in Chronic Widespread Pain With or Without Fibromyalgia
Status: COMPLETED
Conditions: Chronic Widespread Pain|Fibromyalgia
Interventions: DRUG: IGN-ES001|DRUG: Parol 500 mg Tablets (acetaminophen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of SC-ICBT for Adults With OCD：A Three-Arm Randomized Controlled Trial
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: OTHER: stepped-care Internet-based cognitive behavioral therapy(SC-ICBT)|OTHER: Cognitive Behavioral Group Therapy (CBGT)|DRUG: conventional medical treatment (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Effect of a Specific Trace Metal Complex Versus Placebo on the Severity of Apnea in Patients With Obstructive Sleep Apnea Syndrome
Status: NOT_YET_RECRUITING
Conditions: Apnea, Obstructive
Interventions: DIETARY_SUPPLEMENT: Nutri PNEA|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Health Promotion in Patients With Early-Stage Breast or Prostate Cancer
Status: COMPLETED
Conditions: Breast Cancer|Depression|Fatigue|Malnutrition|Prostate Cancer|Psychosocial Effects of Cancer and Its Treatment
Interventions: PROCEDURE: fatigue assessment and management|PROCEDURE: nutritional support|PROCEDURE: physical therapy|PROCEDURE: psychosocial assessment and care|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: OTHER
Clinical trial: MK0952 in Patients With Mild-to-Moderate Alzheimer's Disease (0952-004)(COMPLETED)
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: MK0952|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of C2N-8E12 in Subjects With Progressive Supranuclear Palsy
Status: COMPLETED
Conditions: Progressive Supranuclear Palsy
Interventions: DRUG: Single dose C2N-8E12|DRUG: Single dose placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Olanzapine Augmentation Therapy in Treatment-resistant Depression: a Double-blind Placebo-controlled Trial
Status: WITHDRAWN
Conditions: Therapy-resistant Depression
Interventions: DRUG: Olanzapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Optimizing Treatment of Peginterferon (PEG IFN) Alpha in Chronic Hepatitis B Virus Patients With Low Level HBsAg
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: peginterferon alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kaneka iED Coil System for the Treatment of Wide Necked Ruptured and Unruptured Intracranial Aneurysms
Status: RECRUITING
Conditions: Intracranial Aneurysms|Wide Neck Intracranial Aneurysms
Interventions: DEVICE: Kaneka i-ED coil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Rising Oral Doses of BI 44847 Administered to Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 44847|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers of Response to Pembrolizumab Combined With Chemotherapy in Non-Small Cell Lung Cancer (KEYNOTE-782, MK-3475-782)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Pemetrexed|DRUG: Carboplatin|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surfactant Positive Airway Pressure and Pulse Oximetry Trial
Status: COMPLETED
Conditions: Infant, Newborn, Diseases|Other Preterm Infants|Infant, Small for Gestational Age|Premature Birth|Bronchopulmonary Dysplasia|Retinopathy of Prematurity
Interventions: DRUG: Surfactant|DEVICE: Continuous Positive Airway Pressure (CPAP)|DRUG: Supplemental oxygen with target saturation of 85 to 89%|DRUG: Supplemental oxygen with target saturation of 91 to 95%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of BI 10773 Administered Twice Daily Compared BI 10773 Given Once Daily After Multiple Oral Doses in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Empagliflozin|DRUG: Empagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: The Colorectal Cancer Chemoprevention Acceleration and Improvement Platform (CRC-CHAMP) Study
Status: UNKNOWN
Conditions: Colorectal Cancer|Colorectal Adenoma|Colorectal Adenomatous Polyp
Interventions: DRUG: acetylsalicylic acid delayed release tablets, 81mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better?
Status: COMPLETED
Conditions: Cleft Lip and Palate|Maxillary Hypoplasia
Interventions: PROCEDURE: Orthognathic surgery|PROCEDURE: Distraction osteogenesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Volumetric Laser Endomicroscopy With Intelligent Real-time Image Segmentation (IRIS)
Status: COMPLETED
Conditions: Barrett's Esophagus Without Dysplasia|Barrett's Esophagus With Dysplasia|Barrett's Esophagus With Low Grade Dysplasia|Barrett's Esophagus With High Grade Dysplasia|Barrett's Esophagus With Dysplasia, Unspecified
Interventions: DIAGNOSTIC_TEST: IRIS (Intelligent real-time image segmentation)|DIAGNOSTIC_TEST: VLE (Volumetric laser endomicroscopy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Huaier Granule on Nephrotoxicity Associated With Targeted Therapy for Advanced Hepatobiliary Malignancies.
Status: RECRUITING
Conditions: Nephrotoxicity
Interventions: DRUG: Huaier Granule|DRUG: VEGFR-TKIs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Volume Support/Assist Control Mode Ventilation and Diaphragmatic Atrophy
Status: RECRUITING
Conditions: Mechanical Ventilation Complication
Interventions: OTHER: Volume Support Mode Mechanical Ventilation|OTHER: Assist Control Mode Mechanical Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating the Within-subject Variability of NN1250 in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin degludec|DRUG: insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Zero to Five Automated Oscillometric Office Blood Pressure (AOBP) Measurement
Status: COMPLETED
Conditions: Hypertension|Cardiovascular Diseases
Interventions: DIAGNOSTIC_TEST: Zero to Five Automated Oscillometric Office Blood Pressure (AOBP) Measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of the Safety and Tolerability of Oral Capsule Form of PCI-24781 in Advanced Cancer Patients
Status: COMPLETED
Conditions: Neoplasms by Site|Lymphoma, Non-hodgkin|Hodgkin Disease|Multiple Myeloma|Leukemia, Lymphocytic, Chronic
Interventions: DRUG: PCI-24781
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Plyometric Training on the Balance Ability of the Lower Limbs in the Elderly
Status: COMPLETED
Conditions: Plyometric Exercise|Elderly|Balance
Interventions: OTHER: Plyometric exercises|OTHER: Regulation Exercises Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Moringa Oleifera Leaf Extract on Postoperative Pain and Bacterial Reduction in Mandibular Premolars
Status: UNKNOWN
Conditions: Necrotic Pulp
Interventions: DIETARY_SUPPLEMENT: Moringa oleifera leaf|DRUG: Sodium hypochlorite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postpartum Exercise and Diastasis Recti Abdominis
Status: COMPLETED
Conditions: Diastasis Recti Abdominis|Diastasis Recti
Interventions: OTHER: Abdominal muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Trastuzumab in Combination With Capecitabine and Oxaliplatin for the Treatment of HER2-positive Advanced Gastric Cancer.
Status: COMPLETED
Conditions: Advanced Gastric Carcinoma
Interventions: DRUG: Trastuzumab|DRUG: Oxaliplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OMNI Study--Assessing Therapies in Medtronic Pacemaker, Defibrillator, and Cardiac Resynchronization Therapy Devices.
Status: TERMINATED
Conditions: Tachycardia, Ventricular|Heart Failure, Congestive|Ventricular Fibrillation|Ventricular Dysfunction|Bradycardia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy Study of PD-616 Plus Cytarabine to Treat Acute Myelogenous Leukemia or Myelodysplastic Syndrome
Status: TERMINATED
Conditions: Acute Myelogenous Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: PD-616
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Telmisartan / HCTZ Fixed Dose Combination Compared to Its Monocomponents in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Telmisartan|DRUG: Hydrochlorthiazide (HCTZ)|DRUG: Telmisartan/HCTZ fixed combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial on Clinical Efficacy of 1% Versus 2% Lignocaine in Cough Suppression and Pain Relief in Patients Undergoing Flexible Bronchoscopy
Status: COMPLETED
Conditions: Lung Cancer|Tuberculosis|Sarcoidosis|Interstitial Lung Disease
Interventions: DRUG: 1% lignocaine|DRUG: 2% lignocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-Based Cognitive Therapy for the Prevention of Perinatal Depressive Relapse/Recurrence
Status: COMPLETED
Conditions: Postpartum Depression|Pregnancy|Depression
Interventions: BEHAVIORAL: MBCT-PD|BEHAVIORAL: OAR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Yoga on Clinical Impact and Psychosocial Aspects of COPD
Status: COMPLETED
Conditions: Chronic Pulmonary Obstructive Disease
Interventions: OTHER: Yoga bhastrika pranayama breathing exercise|OTHER: Pulmonary Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER
Status: RECRUITING
Conditions: Colorectal Cancer|Coffee|Gastrointestinal Microbiome|Stenosis|Fibrosis, Liver|Ultrasound Elastography|Proton Magnetic Resonance Spectroscopy
Interventions: DRUG: Nestlé NESCAFÉ® TASTER'S CHOICE® House Blend capsule.|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Vitamin B12 Treatment in Singers
Status: COMPLETED
Conditions: Vitamin B 12 Deficiency
Interventions: DRUG: Cyanocobalamin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaginal Practices in Human Immunodeficiency Virus (HIV) Positive Women in Zambia, a Bio-Behavioral Intervention "WASH-2"
Status: COMPLETED
Conditions: Vaginosis, Bacterial
Interventions: BEHAVIORAL: Women's and Sexual Health [WASH]|BEHAVIORAL: Enhanced Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Oral Decontamination Using Chlorhexidine or Potassium Permanganate in ICU Patients
Status: COMPLETED
Conditions: Nosocomial Pneumonia|Healthcare-Associated Pneumonia|Aspiration Pneumonia|Ventilator-Associated Pneumonia
Interventions: DRUG: Chlorhexidine gluconate|DRUG: Potassium permanganate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Preventing and Arresting Dental Root Surface Caries in Community-dwelling Older Adults
Status: COMPLETED
Conditions: Dental Caries
Interventions: DRUG: silver diammine fluoride|OTHER: Water as placebo|OTHER: saturated potassium iodide solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Efficacy and Safety of Omalizumab Through 48 Weeks in Participants With Chronic Idiopathic Urticaria
Status: COMPLETED
Conditions: Urticaria
Interventions: DRUG: Omalizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Normal Saline Flushes at 12 vs 24 Hours Intervals for Maintaining Peripheral Intravenous Catheters Patency
Status: COMPLETED
Conditions: Pain
Interventions: PROCEDURE: Flushing with positive pressure|DRUG: Normal saline|DEVICE: MicroClave ICU Medica
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intrauterine Contraceptive Device Insertion During Cesarean Section (CS) Versus Delayed Insertion
Status: COMPLETED
Conditions: Contraception|IUD
Interventions: PROCEDURE: postplacental IUD insertion|PROCEDURE: delayed IUD insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Thyroid Hormone Replacement for Subclinical Hypothyroidism and Dyslipidemia in ASCVD (ThyroHeart-Lipid Study)
Status: UNKNOWN
Conditions: Dyslipidemia|Subclinical hypothyroïdism|Statin|ASCVD
Interventions: DRUG: Pitavastatin and placebo|DRUG: Pitavastatin and levothyroxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Participants to Evaluate the Effects of Multiple Doses of JNJ-55308942 on Cytochrome P450 Substrate Activity and on the Pharmacokinetics of Levonorgestrel/Ethinyl Estradiol
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-55308942 High Dose|DRUG: JNJ-55308942 Low Dose|DRUG: Levonorgestrel/Ethinyl Estradiol Fixed Dose combination (FDC)|DRUG: Drug Cocktail:Midazolam (2mg)/Omeprazole (20mg)/Dextromethorphan (30mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Low Tidal MEChanical Ventilation Against NO Ventilation During Cardiopulmonary Bypass Heart Surgery
Status: COMPLETED
Conditions: Respiratory Failure|Atelectasis|Pneumonia|Pneumothorax|Bleeding|Surgery--Complications|Cardiac Disease
Interventions: PROCEDURE: Low tidal volume ventilation (LTV arm)|PROCEDURE: No ventilation (noV arm)|PROCEDURE: Lung recruitment manoeuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Self-Compassion to Enhance the Well-Being of Caregivers of Children With Physical Disabilities
Status: COMPLETED
Conditions: Stress|Caregiver Burden|Anxiety|Depressive Symptoms
Interventions: BEHAVIORAL: Self-Compassion Based Resilient Caregiving Course
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Immunogenicity and Efficacy of R21 Matrix-M in 5-17 Month Old Children in Nanoro, Burkina Faso
Status: COMPLETED
Conditions: Malaria,Falciparum
Interventions: BIOLOGICAL: R21 adjuvanted with 25mcg Matrix-M|BIOLOGICAL: Rabies Vaccine|BIOLOGICAL: R21 adjuvanted with 50mcg Matrix-M
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Compressive Cryotherapy Versus Conventional Cryotherapy After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Arthropathy|Cryotherapy Effect
Interventions: OTHER: cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Informed Decision-Making Regarding Prostate Specific Antigen (PSA) Screening in 50-70 Year Old Latino Men
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: BEHAVIORAL: Intervention Session|BEHAVIORAL: Printed Material
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparative Use of Tranexamic Acid Intravenous and Topical Application in Intertrochanteric Fractures With PFNA
Status: RECRUITING
Conditions: Hemorrhage|Fracture Femur
Interventions: DRUG: Tranexamic acid|OTHER: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tamoxifen to Reduce Unscheduled Bleeding in New Users of the Levonorgestrel-releasing Intrauterine System (LNG-IUS)
Status: COMPLETED
Conditions: Menorrhagia|Metrorrhagia|Medicated Intrauterine Devices
Interventions: DRUG: Tamoxifen|DRUG: Placebo (for Tamoxifen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Is Prolonged Period of Prone Position Effective and Safe in Mechanically Ventilated Patients With SARS-COV-2?
Status: COMPLETED
Conditions: COVID-19 Acute Respiratory Distress Syndrome
Interventions: PROCEDURE: prolonged prone position ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: IPA Targeted Adoptive Immunotherapy vs Adult Haplo-identical Cell Infusion During Induction of High Risk Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: BIOLOGICAL: haplo-identical cells (donor)|BIOLOGICAL: umbilical cord blood unit (CBU)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study to Evaluate Uncorrected Distance Vision and Quality of Vision After Light Treatments of an Implanted RxSight Light Adjustable Lens (RXLAL) With The Light Delivery Device (LDD) in Subjects With Preoperative Corneal Astigmatism
Status: COMPLETED
Conditions: Aphakia|Cataract
Interventions: DEVICE: Light Adjustable lens (LAL) and Light Delivery Device (LDD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RAD001 Plus Best Supportive Care (BSC) Versus BSC Plus Placebo in Patients With Metastatic Carcinoma of the Kidney Which Has Progressed After Treatment With Sorafenib and/or Sunitinib
Status: COMPLETED
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: RAD001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: USE THE SYSTEMIC METFORMIN IN MELASMA
Status: UNKNOWN
Conditions: Melasma
Interventions: DRUG: MetFORMIN 1000 Mg Oral Tablet|DRUG: Placebos|DRUG: Trichloroacetic Acid Peeling|DRUG: MetFORMIN 500 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Low Glycemic Index on Gestational Diabetes Mellitus
Status: COMPLETED
Conditions: Gestational Diabetes Mellitus
Interventions: OTHER: Standard Nutrition Therapy|OTHER: Low Glycemic Index
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Drug Interaction Study of Warfarin and Canagliflozin in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Canagliflozin/Warfarin|DRUG: Canagliflozin/Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Vemurafenib + Fotemustine to Treat Advanced Melanoma Patients With V600BRAF Mutation Recurred While on Vemurafenib
Status: COMPLETED
Conditions: Malignant Melanoma Stage IV
Interventions: DRUG: Fotemustine + Vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EBUS Guided Cryobiopsies With Ultrathin Cryoprobe in Patients With Peripheral Pulmonary Nodules - a Feasibility Study
Status: COMPLETED
Conditions: Transbronchial Cryobiopsy
Interventions: DEVICE: EBUS cryo probe
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With HIV Infection
Status: TERMINATED
Conditions: Adult B Acute Lymphoblastic Leukemia|Chronic Lymphocytic Leukemia|Cutaneous B-Cell Non-Hodgkin Lymphoma|Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue|HIV Infection|Intraocular Lymphoma|Multicentric Angiofollicular Lymphoid Hyperplasia|Nodal Marginal Zone Lymphoma|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Immunoblastic Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Refractory Plasma Cell Myeloma|Small Intestinal Lymphoma|Splenic Marginal Zone Lymphoma|Testicular Lymphoma|Waldenstrom Macroglobulinemia
Interventions: DRUG: Ibrutinib|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Hepatitis C Virus Entry Inhibitor (ITX 5061) in Liver Transplant Recipients
Status: COMPLETED
Conditions: Hepatitis C|Evidence of Liver Transplantation
Interventions: DRUG: ITX 5061
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simvastatin to Prevent SCI-Induced Bone Loss
Status: UNKNOWN
Conditions: Spinal Cord Injuries|Osteoporosis
Interventions: DRUG: Placebo Oral Capsule|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Psychosocial Outcomes in Caregivers of Children With Food Allergy
Status: COMPLETED
Conditions: Food Allergy in Children|Caregiver Burnout|Psychosocial Problem|Family Research
Interventions: BEHAVIORAL: Enhanced mobile app with standard of care and education|BEHAVIORAL: Enhanced mobile app with standard of care, education and support resources
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SAD Evaluation of Safety, Tolerability, PK, and PD of MDI-2517 in Healthy Participants
Status: RECRUITING
Conditions: Safety and Tolerability
Interventions: DRUG: MDI-2517|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Immune Response to Pneumococcal Vaccine in Alefacept-treated Adults With Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Chronic Plaque Psoriasis
Interventions: DRUG: alefacept|DRUG: polyvalent pneumococcal vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Extension Study to Assess Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis
Status: WITHDRAWN
Conditions: Uveitis
Interventions: BIOLOGICAL: AIN457|BIOLOGICAL: AIN457|BIOLOGICAL: AIN457|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MENIPREP STUDY : EVALUATION OF THE EFFECTIVENESS OF PRP INJECTION IN THE MANAGEMENT OF DEGENERATIVE MENISCAL LESIONS: RANDOMIZED CONTROLLED TRIAL DOUBLE BLIND VERSUS REFERENCE TREATMENT"
Status: UNKNOWN
Conditions: DEGENERATIVE MENISCAL LESIONS
Interventions: DRUG: injection of Platelet Enhanced Plasma(PRP)|DRUG: injection of corticosteroids|DEVICE: RMI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Deep Transcranial Magnetic Stimulation (DTMS) With the H-ADD Coil as an Aid to Smoking Cessation.
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DEVICE: Sham Treatment|DEVICE: Active dTMS Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Immunosuppressive Effects of Mycophenolate Mofetil and Valganciclovir in Kidney Transplant Recipients
Status: COMPLETED
Conditions: Renal Failure
Interventions: PROCEDURE: phlebotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Investigate the Effect of IOP-lowering With TO-O-1001 Eye Drops in Healthy Subjects and in Patients With Open-Angle Glaucoma or Ocular Hypertension
Status: ACTIVE_NOT_RECRUITING
Conditions: Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: TO-O-1001|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SAFIR Family Talk - Investigating the Effect of The Family Talk Intervention
Status: RECRUITING
Conditions: Mental Disorder|Family|Child|Parenting|Resilience|Prevention
Interventions: BEHAVIORAL: Family Talk Preventive Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With DLBCL
Status: RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Acalabrutinib|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of High Dose Intravenous Immune Globulin (IVIG) Plus Standard Medical Treatment (SMT) Versus SMT Alone in Participants in Intensive Care Unit (ICU) With Coronavirus Disease (COVID-19)
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: GAMUNEX-C|DRUG: Standard Medical Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Multicenter Observational Study on MAST™ (Minimal Access Spinal Technologies) Fusion Procedures for the Treatment of the Degenerative Lumbar Spine
Status: COMPLETED
Conditions: Degenerative Lumbar Spine Causing Back and/or Leg Pain|Lumbar Spine Degeneration
Interventions: DEVICE: MAST™ procedure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Investigation Into the Effectiveness and Safety of Five Water Based Personal Lubricants.
Status: COMPLETED
Conditions: Dyspareunia|Vaginal Dryness
Interventions: DEVICE: Lubricant A|DEVICE: Lubricant B|DEVICE: Lubricant C|DEVICE: Lubricant D|DEVICE: Lubricant E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluating Endostatin Plus TC Regimen in Secondary Malignant Neoplasm of Liver Using Contrast Enhancement Ultrasonography
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer|Nasopharyngeal Cancer|Liver Metastasis
Interventions: DRUG: Paclitaxel , carboplatin, endostatin|DRUG: Paclitaxel and Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Devintec OR-AT0222 Oral Gel for the Treatment of Canker Sores: A Double Blind, Randomized, Placebo Controlled Clinical Investigation
Status: RECRUITING
Conditions: Recurrent Aphthous Ulcer
Interventions: DEVICE: OR-AT0222|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Metabolism and Excretion of [14C]-CC-90009 in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: CC-90009|RADIATION: [14C]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BOO and DU and Their Clinical and Urodynamic Findings in Women With ≥Stage II Cystocele
Status: COMPLETED
Conditions: Bladder Outlet Obstruction and Detrusor Underactivity in Women With Severe Cystocele
Interventions: DIAGNOSTIC_TEST: Pad test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p