pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A First in Human Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics Effects of OC514
Status: COMPLETED
Conditions: Cancer Cachexia
Interventions: DRUG: OC514 (Low dose)|DRUG: OC514 (Mid dose)|DRUG: OC514 (High dose)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Experimental Human Infection With Neisseria Gonorrhoeae (LptA Trial)
Status: COMPLETED
Conditions: Gonococcal Infection
Interventions: DRUG: Azithromycin|DRUG: Ceftriaxone|DRUG: Ciprofloxacin|BIOLOGICAL: Neisseria gonorrhoeae strain FA1090 A26|BIOLOGICAL: Neisseria gonorrhoeae strain FA7527
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Feasibility Study of Robotic Assisted Transanal Total Mesorectal Excision for Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer|Perioperative Complication
Interventions: PROCEDURE: Robotic assisted transanal total mesorectal excision|PROCEDURE: Laparoscopic assisted transanal total mesorectal excision
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Computer-Assisted Scheduling of Nicotine Inhaler Use in Participants Who Plan to Stop Smoking
Status: COMPLETED
Conditions: Esophageal Cancer|Head and Neck Cancer|Lung Cancer
Interventions: BEHAVIORAL: smoking cessation intervention|DRUG: nicotine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: A Study of BMS-562086 in Patients With Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Placebo|DRUG: BMS-562086
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: NT-I7 for the Treatment of Recurrent Squamous Cell Carcinoma of Head and Neck Undergoing Surgery
Status: RECRUITING
Conditions: Recurrent Head and Neck Squamous Cell Carcinoma|Recurrent Hypopharyngeal Squamous Cell Carcinoma|Recurrent Laryngeal Squamous Cell Carcinoma|Recurrent Oral Cavity Squamous Cell Carcinoma|Recurrent Oropharyngeal Squamous Cell Carcinoma|Resectable Oropharyngeal Squamous Cell Carcinoma
Interventions: BIOLOGICAL: Efineptakin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Two Recombinant Human Erythropoietin Products in Chronic Kidney Disease Patients
Status: NOT_YET_RECRUITING
Conditions: Anemia of Chronic Kidney Disease
Interventions: BIOLOGICAL: Experimental: Epoetin alfa Megalabs® Erythropoietin injectable in intravenous administration.|BIOLOGICAL: Active comparator: European Union licenced epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Investigating a Restorative Wound Care Cream Together With Petrolatum on Surgical Excisions
Status: COMPLETED
Conditions: Wound Heal|Scar|Keloid|Surgical Wound
Interventions: OTHER: Vehicle Cream Base Emulsion Moisturizer + Petrolatum|OTHER: FS2 Emulsion Moisturizer + Petrolatum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Influence of Music on 6 Minutes Walking Distance in Healthy Children
Status: COMPLETED
Conditions: Healthy Children
Interventions: BEHAVIORAL: Listening to fast music|BEHAVIORAL: Listening to preferred music|BEHAVIORAL: Listening to slow music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Relative Bioavailability of Pyronaridine-artesunate in Tablet and Granule Formulations in Healthy Volunteers
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Pyronaridine-artesunate granules|DRUG: Pyronaridine-artesunate tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of MGD013 in Patients With Melanoma
Status: TERMINATED
Conditions: Unresectable, Recurrent or Metastatic Melanoma|Untreated Mucosal or Acral Lentiginous Melanoma
Interventions: DRUG: MGD013
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficiency of MSC in Refractory Crohn's Disease
Status: UNKNOWN
Conditions: Crohn's Disease
Interventions: DRUG: Routine Treatment of CD|BIOLOGICAL: MSC treatment 01|BIOLOGICAL: MSC treatment 02|OTHER: NS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Control in Dentin Hypersensitivity in Patients With MIH
Status: UNKNOWN
Conditions: Hypersensitivity Dentin
Interventions: PROCEDURE: Hygiene Guidance|PROCEDURE: Sealant Application|RADIATION: Low Level Laser Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ph1b/2 Study of PF-04136309 in Combination With Gem/Nab-P in First-line Metastatic Pancreatic Patients
Status: TERMINATED
Conditions: Metastatic Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: PF-04136309|DRUG: Nab-paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Persistence of Antibody Levels and Response to Fifth or Third Meningococcal B Recombinant Vaccine in 4-year Old Healthy Children Who Previously Participated in Study V72P12E1
Status: COMPLETED
Conditions: Meningococcal Disease|Meningococcal Meningitis
Interventions: BIOLOGICAL: 1 dose of Meningococcal (group B) multicomponent recombinant adsorbed vaccine|BIOLOGICAL: 2 doses of Meningococcal (group B) multicomponent recombinant adsorbed vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Shared Responsibility Between General Practitioners and Highly Specialized Hospitals in Spinal Cord Injury
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: OTHER: Teaching to GPs|OTHER: Site visits to GP practices
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Telemedicine Crohn's Disease and Ulcerative Colitis (TECCU)
Status: COMPLETED
Conditions: Crohn's Disease|Colitis, Ulcerative
Interventions: DEVICE: Telemedicine|DEVICE: Telephone|OTHER: Conventional care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A Study to Evaluate the Nipocalimab and Certolizumab Combination Therapy in Participants With Active Rheumatoid Arthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Placebo|DRUG: Nipocalimab|DRUG: Certolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety/Tolerability, Pharmacokinetics, and Pharmacodynamics of BIBB 1464 MS in Healthy Male Subjects, Combined With Preliminary Evaluation of Relative Bioavailability and Effect of Food
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIBB 1464 MS tablet|DRUG: BIBB 1464 MS solution|DRUG: BIBB 1464 MS placebo|OTHER: Standard dinner
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparative Efficacy and Safety Study of Dolutegravir and Lopinavir/Ritonavir in Second-line Treatment
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: DTG|DRUG: LPV/RTV|DRUG: Two NRTIs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Myopia in University Students Using Dual Focus Soft Contact Lenses
Status: NOT_YET_RECRUITING
Conditions: Myopia, Progressive
Interventions: DEVICE: MiSight contact lenses|DEVICE: Proclear contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: United States Coronary Artery Bypass Surgery (CABG) Diabetes Project (USCDP) Pilot Study
Status: UNKNOWN
Conditions: Diabetes|Coronary Artery Disease
Interventions: DRUG: Strict Glycemic Control for one year post-op CABG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Bioavailability and to Compare the Pharmacokinetics of AZD7594 Inhaled Via Monodose Inhaler and Multiple-dose Dry Powder Inhalers (DPI) or Pressurized Metered-dose Inhaler (pMDI) in Healthy Male Subjects
Status: COMPLETED
Conditions: Asthma|Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: AZD7594 Solution for infusion (150 μg intravenous formulation)|DRUG: AZD7594 Oral suspension (1200 μg oral formulation)|DRUG: AZD7594 Inhalation powder (400 μg) by DPI Device 1 (monodose inhaler)|DRUG: AZD7594 Inhalation powder (400 μg) by DPI device 2 (multiple-dose inhaler)|DRUG: AZD7594 Pressurized inhalation suspension (400 μg) by pMDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dengue 3 Human Infection Model (DENV-3)
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: Dengue virus 3 Live Virus Human Challenge (DENV-3-LVHC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Female Participants With Interstitial Cystitis /Bladder Pain Syndrome (MK-7264-005)
Status: TERMINATED
Conditions: Bladder Pain Syndrome
Interventions: DRUG: Gefapixant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Adalimumab in Subjects With Inactive Uveitis
Status: COMPLETED
Conditions: Uveitis
Interventions: DRUG: Adalimumab|DRUG: Prednisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Apremilast 20mg|DRUG: Apremilast 30mg|DRUG: Placebo + 20 mg Apremilast|DRUG: Placebo + 30 mg Apremilast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy of Phenytoin With Levetireacetam for the Management of Children With Status Epilepticus
Status: UNKNOWN
Conditions: Status Epilepticus
Interventions: DRUG: intravenous levetireacetam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Open Label Study to Evaluate the Pharmacokinetics, Safety, Tolerability and Efficacy of Deferasirox Administered to Chinese Patients With β-thalassemia Major Aged From 2 to Less Than 6 Years Old
Status: WITHDRAWN
Conditions: β-thalassemia Major
Interventions: DRUG: Deferasirox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dopamine Agonist for Hemispatial Neglect and Motor Deficit Post Stroke
Status: COMPLETED
Conditions: Right Hemisphere Stroke|Hemispatial Neglect|Motor Deficit
Interventions: DRUG: Rotigotine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Readiness Network FSHD France: Prospective 24 Months MRI Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Muscular Dystrophy|Facioscapulohumeral
Interventions: DIAGNOSTIC_TEST: Validation of new COA for FSHD patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Performance Evaluation by Magnetic Resonance Imaging (MRI) of Intramuscular Thigh Injections With 3 Configurations of Needle-free Injector (ZENEO®)
Status: UNKNOWN
Conditions: No Condition
Interventions: COMBINATION_PRODUCT: Intramuscular ZENEO® injection of nominal strength|COMBINATION_PRODUCT: Intramuscular ZENEO® injection of low strength (upper limit)|COMBINATION_PRODUCT: Intramuscular ZENEO® injection of low strength (lower limit)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neoadjuvant Anti-PD-1 Antibody (Toripalimab) or Combined With Chemotherapy in HNSCC Patients
Status: UNKNOWN
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Toripalimab|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: 5-fu
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase IIb Safety and Efficacy Study of Four Dose Regimens of BAY1021189 in Patients With Heart Failure and Preserved Ejection Fraction Suffering From Worsening Chronic Heart Failure (SOCRATES-PRESERVED)
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Vericiguat (BAY1021189) (1.25 mg)|DRUG: Vericiguat (BAY1021189) (5 mg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Avapritinib in CBF-AML With KIT Mutations
Status: RECRUITING
Conditions: Core Binding Factor Acute Myeloid Leukemia|KIT Mutation-Related Tumors
Interventions: DRUG: Avapritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TLI, TBI, ATG & Hematopoietic Stem Cell Transplantation and Recipient T Regs Therapy in Living Donor Kidney Transplantation
Status: RECRUITING
Conditions: Living Donor Kidney Transplantation
Interventions: BIOLOGICAL: Infusion of Donor Hematopoetic Stem Cells and Recipient Tregs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The TElemonitoring in the Management of Heart Failure (TEMA-HF) 1 Long-term Follow-up Study
Status: COMPLETED
Conditions: Telemonitoring in Coronary Artery Disease
Interventions: OTHER: Telemonitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety of 1 New 6:2 Influenza Virus Reassortant in Adults for the 2017-2018 Season
Status: COMPLETED
Conditions: Influenza|Healthy
Interventions: BIOLOGICAL: Monovalent Influenza Vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Alprazolam as Conscious Sedation for Upper Gastrointestinal Endoscopy
Status: COMPLETED
Conditions: Diagnostic Esophagogastroduodenoscopy
Interventions: DRUG: Oral alprazolam|DRUG: Sublingual alprazolam|DRUG: Oral placebo|DRUG: Sublingual placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Value of Continuous Noninvasive Hemoglobin Monitoring Using Masimo Radical -7 Pulse CO-Oximeter in Intraoperative Blood Transfusion Practice During Obstetric Procedures
Status: COMPLETED
Conditions: Masimo Radical Pulse Co-oximeter in Intraoperative Blood Transfusion Practice During Obestatric Procedure
Interventions: DEVICE: of Masimo Radical-7¿ Pulse CO-Oximeter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sputum-guided Treatment With Comprehensive Care Management in COPD - A Randomized-controlled Trial
Status: RECRUITING
Conditions: COPD
Interventions: COMBINATION_PRODUCT: Sputum-guided management and comprehensive care management|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: 2D Strain Evaluation: Children With Duchenne Muscular Dystrophy Versus Healthy Children
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: OTHER: speckle tracking (2D strain) echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase IIIb, Multinational, Multicenter, Open-Label Extension Study Assessing the Long-Term Safety of PRN Intravitreal Injections of DE-109 in Subjects With Non-Infectious Uveitis of the Posterior Segment of the Eye Who Have Participated in the SAKURA Development Program
Status: COMPLETED
Conditions: Non-Infectious Uveitis of the Posterior Segment of the Eye
Interventions: DRUG: DE-109 440 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid Receptors Influence Ischemia-Reperfusion Injury
Status: SUSPENDED
Conditions: Ischemia-Reperfusion Injury
Interventions: DRUG: morphine|DRUG: naloxone|DRUG: Technetium-TC99m-labeled Annexin A5|PROCEDURE: forearm ischemic exercise|PROCEDURE: ten minute forearm ischemia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose:
Clinical trial: Mandibular Full-arch Rehabilitation With Internal Hexagonal and Conical Connection Implants
Status: ACTIVE_NOT_RECRUITING
Conditions: Edentulous Jaw
Interventions: DEVICE: Mandibular partial rehabilitation with IF Tapared implants|DEVICE: Mandibular partial rehabilitation with CF Tapared implants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smoking Cessation and a Teachable Moment in Patients With Acute Fractures
Status: COMPLETED
Conditions: Tobacco Use Disorder|Bone Fractures
Interventions: BEHAVIORAL: Teaching intervention|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Determine the Bioavailability of Vonoprazan Sprinkle Capsules on Pudding or on Applesauce Relative to a Vonoprazan Tablet in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Vonoprazan|DRUG: Vonoprazan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Rebif Compared to Tecifdera on Six-month Outcomes in Patients With Relapsing-remitting MS
Status: WITHDRAWN
Conditions: Multiple Sclerosis
Interventions: DRUG: Rebif (IFN β-1a subcutaneous three times per week)|DRUG: Tecifdera (dimethyl fumarate)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Community-based Rehabilitation and Fall Prevention Program After Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Knee Osteoarthritis|Fall
Interventions: OTHER: Fall prevention program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Specialized Versus Standard Compression After Saphenous Ablation
Status: UNKNOWN
Conditions: Varicose Veins
Interventions: PROCEDURE: Compression stockings|DEVICE: compression stockings (Sigvaris )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Anlotinib for Advanced and Refractory Natural Killer /T-cell Lymphoma
Status: COMPLETED
Conditions: Natural Killer/T-Cell Lymphoma, Nasal and Nasal-Type
Interventions: DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antiproteinuric Effects of Liraglutide Treatment
Status: COMPLETED
Conditions: Diabetic Kidney Disease
Interventions: DRUG: Liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Intragastric Balloon Placement for Weight Loss in Liver Transplant Waitlist Candidates
Status: TERMINATED
Conditions: Obesity|Liver Cirrhosis
Interventions: DEVICE: ORBERA Intragastric Balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of AGB101 in Mild Cognitive Impairment Due to Alzheimer's Disease
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Prodromal Alzheimer's Disease
Interventions: DRUG: Placebo Oral Tablet|DRUG: AGB101 220 mg tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sensor-Assisted Prevention of Dehydration in Head and Neck Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer
Interventions: BEHAVIORAL: Quality of Life Survey|BEHAVIORAL: Health Management Surveys|OTHER: Monitoring Devices|BEHAVIORAL: Symptoms Surveys|BEHAVIORAL: Device Usability Survey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 3T Endorectal Magnetic Resonance Spectroscopic Imaging (MRSI) of Prostate
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: PROCEDURE: AIR-MRSI|PROCEDURE: PFC-MRSI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immune Tolerance Study With Aldurazyme® (Laronidase)
Status: COMPLETED
Conditions: Mucopolysaccharidosis I
Interventions: BIOLOGICAL: Laronidase|DRUG: Cyclosporine A (CsA)|DRUG: Azathioprine (Aza)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melatonin in Smoke-induced Vascular Injury
Status: COMPLETED
Conditions: Smoking|Vascular System Injuries
Interventions: OTHER: non-smoker oral placebo|DRUG: non-smoker oral melatonin|OTHER: smoker oral placebo|DRUG: smoker oral melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Hypoglycemic Drugs on Testosterone Levels in Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Insulin|DRUG: Metformin|DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Animated Cartoon for Prevention of Emergence Agitation in Children Aged 1.5 - 5 yr After General Anesthesia
Status: UNKNOWN
Conditions: Sevoflurane Anaesthesia
Interventions: OTHER: watching animated cartoon before general anesthesia|OTHER: not watching animated cartoon beofre general anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Combined Molecular Testing for Influenza, SARS-CoV-2, and RSV RNA From Different Upper Airway Specimens.
Status: RECRUITING
Conditions: Influenza|COVID-19|RSV Infection
Interventions: DIAGNOSTIC_TEST: (NPS right - Nasal swab left - OPS)|DIAGNOSTIC_TEST: (NPS left - Nasal swab right - OPS)|DIAGNOSTIC_TEST: (Nasal swab right - NPS left - OPS)|DIAGNOSTIC_TEST: (Nasal swab left - NPS right - OPS)|DIAGNOSTIC_TEST: (NPS right - OPS - Nasal swab left)|DIAGNOSTIC_TEST: (NPS left - OPS - Nasal swab right)|DIAGNOSTIC_TEST: (Nasal swab right - OPS - NPS left)|DIAGNOSTIC_TEST: (Nasal swab left - OPS - NPS right)|DIAGNOSTIC_TEST: (OPS - NPS right - Nasal swab left)|DIAGNOSTIC_TEST: (OPS - NPS left - Nasal swab right)|DIAGNOSTIC_TEST: (OPS - Nasal swab left - NPS right)|DIAGNOSTIC_TEST: (OPS - Nasal swab right - NPS left)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Impact of Domiciliary Versus 'Hub' Based Comprehensive Geriatric Assessment on Clinical and Process Outcomes Among Older Adults Attending Community Specialist Teams: a Randomised Controlled Trial.
Status: RECRUITING
Conditions: Frailty|Comprehensive Geriatric Assessment|Older Adults|Domiciliary Care
Interventions: OTHER: CGA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of TRO19622 in the Treatment of Patients With Chemotherapy Induced Peripheral Neuropathy
Status: COMPLETED
Conditions: Chemotherapy-Induced Peripheral Neuropathy
Interventions: DRUG: Olesoxime (TRO19622)|DRUG: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: School Intervention With Daily Physical Activity and Healthy Food for Students With an Intellectual Disability.
Status: COMPLETED
Conditions: Weight Loss|Food Habits|Mental Retardation
Interventions: BEHAVIORAL: Healthier, Smarter, Happier
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Study in Treatment of Malignant Ascites of Ovarian Cancer With Intraperitoneal Injection Bevacizumab Combined With Intraperitoneal Hyperthermic Perfusion Chemotherapy
Status: UNKNOWN
Conditions: Ovarian Cancer With Malignant Ascites
Interventions: DRUG: Bevacizumab|DRUG: TC:paclitaxel + carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study of 100 mg Flavoxate Hydrochloride Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Flavoxate Hydrochloride Tablets, 100mg|DRUG: Urispas® Tablets, 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Web-based Cognitive Behavioural Treatment for Adolescents With Chronic Fatigue Syndrome
Status: COMPLETED
Conditions: Chronic Fatigue Syndrome
Interventions: BEHAVIORAL: FitNet treatment|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Vitamin D in Corneal Epithelial Barrier Function, Ocular Microbiome, Ocular Inflammation, and Visual Acuity of Children With Allergic Conjunctivitis
Status: ENROLLING_BY_INVITATION
Conditions: Allergic Conjunctivitis
Interventions: OTHER: Vitamin D|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: liposomal amphotericin B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Diuretics Withdrawal in Chronic Heart Failure With Reduced Ejection Fraction
Status: RECRUITING
Conditions: Heart Failure|Electric Impedance|Dyspnea|Safety|Withdrawal
Interventions: DRUG: Diuretics withdrawal|DRUG: Diuretics maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Product 0405 to a Vehicle Control in the Treatment of Mild to Moderate Atopic Dermatitis in Pediatric Subjects
Status: WITHDRAWN
Conditions: Atopic Dermatitis
Interventions: DRUG: Product 0405|DRUG: Placebo for Product 0405
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glycemic Index of Cacao Fruit Pulp in Healthy, Human Subjects
Status: COMPLETED
Conditions: Blood Sugar; High|Blood Sugar; Low
Interventions: OTHER: Cacao fruit pulp|OTHER: Dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Pharmacokinetic Study of OMT-28 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: OMT-28|OTHER: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: LIpitor and biGuanide to Androgen Delay Trial
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: DRUG: Metformin|DRUG: Atorvastatin|DRUG: Placebo (corresponding to metformin)|DRUG: Placebo (corresponding to atorvastatin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Antifungal Agents and Infrared Thermotherapy Alone or in Combination in the Treatment of Sporotrichosis
Status: NOT_YET_RECRUITING
Conditions: Sporotrichosis
Interventions: DRUG: Itraconazole|DEVICE: Infrared thermotherapy apparatus|OTHER: Itraconazole and Infrared thermotherapy apparatus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Mesenchymal Stem Cells in Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis of Knee
Interventions: BIOLOGICAL: Ex- vivo cultured adult allogeneic MSCs|BIOLOGICAL: Plasmalyte-A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ipatasertib Plus Abiraterone Plus Prednisone/Prednisolone, Relative to Placebo Plus Abiraterone Plus Prednisone/Prednisolone in Adult Male Patients With Metastatic Castrate-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Metastatic Prostate Cancer
Interventions: DRUG: Ipatasertib|DRUG: Abiraterone|DRUG: Placebo|DRUG: Prednisone/Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Tolerability of a PARP Inhibitor in Combination With Topotecan
Status: COMPLETED
Conditions: Malignant Solid Tumors
Interventions: DRUG: KU-0059436 (AZD2281)(PARP inhibitor)|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Immuno-therapy Study of Nivolumab in Combination With Experimental Medication BMS-986205 Compared to Standard of Care EXTREME Regimen in First-line Recurrent/Metastatic Squamous Cell Carcinoma of Head and Neck
Status: WITHDRAWN
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: Nivolumab|DRUG: BMS-986205|BIOLOGICAL: Cetuximab|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ARJ C13 Urea Breath Test System
Status: COMPLETED
Conditions: H. Pylori Infection
Interventions: COMBINATION_PRODUCT: PyloPlus UBT System|DIAGNOSTIC_TEST: Histology|DIAGNOSTIC_TEST: Rapid Urease Test|DIAGNOSTIC_TEST: H.pylori Culture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Radiological Changes of Glymphatic-meningeal Lymphatic Drainage System After Subarachnoid Hemorrhage
Status: RECRUITING
Conditions: Subarachnoid Hemorrhage|Lymphatic System Disorder|Meningeal Lymphatic Vessels
Interventions: DIAGNOSTIC_TEST: subarachnoid hemorrhage
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Skin Tolerance Study of Betamethasone Creams in Atopic Eczema and the Preventative Properties of a Moisturiser
Status: COMPLETED
Conditions: Atopic Eczema
Interventions: DRUG: betamethasone valerate|DRUG: betamethasone valerate|DRUG: urea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Smoking Cessation Smartphone App for Cancer Patients (Quit2Heal Study)
Status: COMPLETED
Conditions: Cancer|Smoking
Interventions: BEHAVIORAL: Experimental smoking cessation smartphone app|BEHAVIORAL: Standard of care smoking cessation smartphone app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: XIENCE V: SPIRIT WOMEN
Status: COMPLETED
Conditions: Coronary Artery Stenosis|Coronary Arteriosclerosis|Coronary Artery Disease|Coronary Artery Restenosis|Total Coronary Occlusion|Stent Thrombosis|Vascular Disease|Myocardial Ischemia
Interventions: DEVICE: XIENCE V®/ XIENCE PRIME™
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine and Delirium in Patients After Cardiac Surgery
Status: COMPLETED
Conditions: Delirium|C.Surgical Procedure; Cardiac|Postoperative Complications
Interventions: DRUG: dexmedetomidine hydrochloride for injection|DRUG: 0.9% sodium chloride for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Gene-Modified Lymphocytes, High-Dose Aldesleukin, and Vaccine Therapy in Treating Patients With Progressive or Recurrent Metastatic Cancer
Status: TERMINATED
Conditions: Kidney Cancer|Melanoma (Skin)|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: anti-p53 T-cell receptor-transduced peripheral blood lymphocytes|BIOLOGICAL: autologous dendritic cell-adenovirus p53 vaccine|BIOLOGICAL: filgrastim|DRUG: cyclophosphamide|DRUG: fludarabine phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetuximab Plus Conformal Thoracic Radiotherapy in Patients (Pts) With Inoperable or Unresectable Locally Advanced Non-Small Cell Lung Cancer (LA - NSCLC)
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Cetuximab|RADIATION: Conformal Thoracic Radiotherapy (CTRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Social Goals and Individual Incentives to Promote Walking in Older Adults
Status: COMPLETED
Conditions: Physical Activity
Interventions: BEHAVIORAL: Financial incentive|BEHAVIORAL: Social Goal|BEHAVIORAL: Personal financial incentives & social goals|BEHAVIORAL: daily pedometer use and weekly feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Smoking Exposure on Smoking Relapse Following Brief Abstinence - 2
Status: COMPLETED
Conditions: Tobacco Use Disorder
Interventions: BEHAVIORAL: Neutral or active cigarette cues
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Continuous Adductor Canal Nerve Blocks: Relative Effects of a Basal Infusion v. Hourly Bolus Doses
Status: COMPLETED
Conditions: Healthy Human Volunteers
Interventions: DRUG: Bolus|DRUG: Basal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Cord Stimulation in Patients With Disorders of Consciousness
Status: UNKNOWN
Conditions: Disorder of Consciousness|Minimally Conscious State|Vegetative State
Interventions: PROCEDURE: spinal cord stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Left Atrial Appendage Closure by Surgery and the Incidence of Stroke in Patients Undergoing Open-heart Surgery.
Status: NOT_YET_RECRUITING
Conditions: Left Atrial Appendage Thrombosis
Interventions: PROCEDURE: the left atrial appendage closure through surgery.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Chemoradiation for Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: Temozolomide|RADIATION: partial brain irradiation|PROCEDURE: stereotactic biopsy of brain tumor|PROCEDURE: craniotomy and tumor resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Safety and PK Study of IV TP-271
Status: COMPLETED
Conditions: Bacterial Infections
Interventions: DRUG: TP-271|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A PK Study to Compare GME751 (Proposed Pembrolizumab Biosimilar) and US-licensed and EU-authorized Keytruda® in Participants With Stage II and III Melanoma
Status: RECRUITING
Conditions: Melanoma
Interventions: DRUG: GME751|DRUG: Keytruda - EU|DRUG: Keytruda - US
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fabrication of Naso-alveolar Molding (NAM) Appliance in Cleft Lip and Palate (CLP) From Digital Magnetic Resonance Imaging (MRI) Face Scan
Status: TERMINATED
Conditions: Cleft Lip and Palate
Interventions: DEVICE: 3D NAM|DEVICE: Traditional NAM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effectiveness of a Short, Intensive and Standardised Spa Therapy for Low Back Pain on Sick Leave Duration
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Spa therapy, exercise and educational therapy|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Piecemeal Versus En Bloc Resection of Large Rectal Adenomas
Status: TERMINATED
Conditions: Colorectal Adenoma With Mild Dysplasia|Colorectal Adenoma With Severe Dysplasia|Colorectal Adenomatous Polyp|Colorectal Low Grade Intraepithelial Neoplasia|Colorectal High Grade Intraepithelial Neoplasia
Interventions: PROCEDURE: en-bloc resection|PROCEDURE: piecemeal resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sustainable Methods, Algorithms, and Research Tools for Delivering Optimal Care Study
Status: COMPLETED
Conditions: Obstructive Sleep Apnea of Adult|Insomnia|Circadian Rhythm Sleep Disorder|Sleep Related Movement Disorders|Narcolepsy and Hypersomnia|Parasomnia
Interventions: OTHER: CONV care for the diagnosis and treatment of sleep disorders|OTHER: PCCM for the diagnosis and treatment of sleep disorders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: S0009 Combination Chemo and Surgery in Stage III or Stage IV Ovarian Cancer
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Peritoneal Cavity Cancer
Interventions: DRUG: carboplatin|DRUG: paclitaxel|PROCEDURE: debulking surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastrointestinal Tolerance of Infant Formula
Status: COMPLETED
Conditions: Gastrointestinal Tolerance
Interventions: OTHER: Experimental 1 Infant Formula|OTHER: Experimental 2 Infant Formula|OTHER: Reference Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: East-West Collaborative Medicine Using Bee-Venom Acupuncture on Whiplash-Associated Disorders
Status: UNKNOWN
Conditions: Whiplash Injuries
Interventions: DEVICE: Bee Venom Acupuncture Therapy|DRUG: zaltoprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glyceryl Trinitrate Ointment vs Posterior Tibial Nerve Stimulation in the Treatment of Anal Fissure
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Glyceryl trinitrate ointment|PROCEDURE: Urgent PC Neuromodulation System®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Efficacy of QRX003 Lotion in Subjects With Netherton Syndrome
Status: RECRUITING
Conditions: Netherton Syndrome
Interventions: DRUG: QRX003-2% Lotion|DRUG: QRX003-4% Lotion QAM|DRUG: Vehicle|DRUG: QRX003-4% Lotion BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Dietary Supplements on Glycemic Control, Body Composition and Hepatic Fat Content in People With Prediabetes
Status: RECRUITING
Conditions: PreDiabetes
Interventions: DIETARY_SUPPLEMENT: Dietary supplement A: Wasabi leaf powder (product of BIOGENA GmbH & Co KG)|DIETARY_SUPPLEMENT: Dietary supplement B: Berberin Phytoactive Gold (product of BIOGENA GmbH & Co KG)|DIETARY_SUPPLEMENT: Dietary supplement C: DiaPhyt® Formula 3.0 (product of BIOGENA GmbH & Co KG)|OTHER: Placebo group 1: Placebo capsules corresponding to DiaPhyt® Formula 3.0/Berberin Phytoactive Gold|OTHER: Placebo group 2: Placebo powder corresponding to Wasabi leaf powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Motive-specific Intervention for Negative Symptoms in Schizophrenia
Status: UNKNOWN
Conditions: Negative Type; Schizophrenic|Anhedonia|Apathy
Interventions: BEHAVIORAL: Motive-specific intervention|BEHAVIORAL: Supportive conversations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Transversus Abdominis Plane Block With Compound Lidocaine and Esketamine on Pain After Surgery
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Normal saline|DRUG: Ropivacaine|DRUG: Compound lidocaine|DRUG: Esketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: S0102: Docetaxel, Vinorelbine, and Filgrastim in Treating Women With Stage IV Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: docetaxel|DRUG: vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prebiotics, Gut Microbiota, and Cardiometabolic Health
Status: COMPLETED
Conditions: Prediabetes
Interventions: DIETARY_SUPPLEMENT: Inulin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Tenoten in the Treatment of Children With Anxiety Disorders
Status: COMPLETED
Conditions: Anxiety Disorder of Childhood
Interventions: DRUG: Tenoten for children|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does a Low-Fat Vegetarian Diet Improve Insulin Resistance in Individuals With Type 2 Diabetes?
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: OTHER: diabetic diet following the DNSG guidelines|OTHER: low-fat vegetarian diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Ripretinib Used for Resectable Metastatic GIST After Failure of Imatinib Therapy
Status: UNKNOWN
Conditions: Gastrointestinal Stromal Tumors
Interventions: DRUG: Ripretinib treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interventional Study in Adults With Immune Thrombocytopenia Purpura (ITP) Receiving Romiplostim
Status: COMPLETED
Conditions: Idiopathic Thrombocytopenic Purpura
Interventions: BIOLOGICAL: Romiplostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT