pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Functional Food Application of Okara Protein Hydrolysate (OPH)- for Anti-exercise-fatigue
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Okara protein hydrolysate (OPH)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Retrospective Analysis of the Effect of In-hospital Initiation of PCSK9i on Clinical Outcomes in Chinese ACS Patients
Status: RECRUITING
Conditions: Acute Coronary Syndrome
Interventions: DRUG: alirocumab 75mg/2week|DRUG: statin ± ezetimibe
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fentanyl Buccal Tablet or Morphine for Exertional Dyspnea in Cancer Patients
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: DRUG: Fentanyl Citrate Buccal Tablet|DRUG: Morphine|OTHER: Physical Performance Testing|OTHER: Placebo Administration|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effect of Deep Margin Elevation Technique on the Clinical Performance of Endocrown Restorations Produced by Computer-Aided Design and Computer-Aided Manufacturing (CAD/CAM) System
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Caries
Interventions: PROCEDURE: Deep Margin Elevation (G-ænial Universal Injectable)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cochlear Implants : Influence of Microphone Aging and Dirtying
Status: COMPLETED
Conditions: Hard of Hearing
Interventions: OTHER: Listening to 12 Fournier's lists of words|OTHER: Listening to 48 Fournier's lists of words
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics of Mefloquine-Artesunate in Pregnant Women With Uncomplicated Plasmodium Falciparum Infection
Status: WITHDRAWN
Conditions: Malaria|Pregnancy
Interventions: DRUG: Mefloquine Artesunate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-center Trial in Adult and Pediatric Patients With Type 1 Diabetes Using Hybrid Closed Loop System and Control at Home
Status: RECRUITING
Conditions: Type 1 Diabetes
Interventions: DEVICE: 670G and 770G Insulin Pump|DEVICE: Subject's Current Diabetes Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measurements Of Lower Limbs And Spine Based On Biplanar Radiographs: Microdose Compared To Standard Dose Protocol
Status: COMPLETED
Conditions: Underdevelopment; Congenital Malformation, Lower Limb|Scoliosis
Interventions: RADIATION: Biplanar x-ray images
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Centrally Acting ACE Inhibition in SLE
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Lisinopril Pills|DRUG: Benazepril Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: LSFG-SKIN, Laser Speckle Flowgraphy
Status: TERMINATED
Conditions: Hypertension|Heart Failure|Vascular Ischemia|Burns|Chemotherapy Effect|Radiation Injuries|Uveitis|Scleritis|Multiple Sclerosis|Autonomic Neuropathy|Stroke|Intracranial Hemorrhages|TIA|Migraine|Headache|Pain
Interventions: DEVICE: laser speckle flowgraphy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Marrow Concentrate Intradiscal Injection for Chronic Discogenic Low Back Pain
Status: COMPLETED
Conditions: Discogenic Pain
Interventions: OTHER: Bone Marrow Concentrate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of a Proton-Pump Inhibitor (Rabeprazole) on the Relative Bioavailability of Cobimetinib in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Cobimetinib|DRUG: Rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Cariprazine (RGH-188) in the Treatment of Patients With Acute Mania
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Cariprazine (RGH-188)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Reduce Symptoms of Premature Beats With Ranolazine
Status: UNKNOWN
Conditions: Premature Ventricular Beats
Interventions: DRUG: Ranolazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Screening in Primary Care of Advanced Liver Fibrosis in NAFLD and/or Alcoholic Patients
Status: RECRUITING
Conditions: Non-alcoholic Fatty Liver Disease (NAFLD)|Alcoholic Liver Disease (ALD)|Liver Fibrosis
Interventions: DIAGNOSTIC_TEST: eLIFT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy
Status: TERMINATED
Conditions: Hypoxic Ischemic Encephalopathy
Interventions: DRUG: Topiramate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transvaginal Ultrasound and Photoacoustic Imaging of the Ovary
Status: COMPLETED
Conditions: Oophorectomy
Interventions: DEVICE: Transvaginal ultrasound|DEVICE: Ultrasound/Photoacoustic imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: High-dose Intravenous Methotrexate Versus Intrathecal Methotrexate for Central Nervous System Prophylaxis in DLBCL
Status: UNKNOWN
Conditions: DLBCL
Interventions: DRUG: Intrathecal methotrexate|DRUG: High-dose intravenous methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Everolimus and Bevacizumab in Advanced Non-Clear Cell Renal Cell Carcinoma (RCC)
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: everolimus and bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 14 Weeks Longitudinal Study to Investigate the Effect of Leukocyte- Platelet Rich Fibrin Plug on the Quality of the Newly Formed Bone in Ridge Preservation Procedure Following a Tooth Extraction. It is a Clinical, Radiographic and Histomorphometric Study.
Status: COMPLETED
Conditions: Alveolar Ridge Preservation|Tooth Extraction
Interventions: BIOLOGICAL: Leukocyte platelet rich fibrin plug + d-PTFE membrane|DEVICE: d-PTFE membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplemental Oxygen in Hypovolemia
Status: COMPLETED
Conditions: Hypovolemia|Hyperoxia
Interventions: DRUG: Oxygen gas|DRUG: Air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Online Wound Electronic Medical Record (OWEMR) to Decrease Amputations in Diabetics
Status: COMPLETED
Conditions: Wounds|Diabetes Complications|Diabetic Foot|Foot Ulcer
Interventions: OTHER: Online Wound Electronic Medical Record
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Post-operative Lower Eyelid Massage for Prevention of the Lower Eyelid Scare Contracture After Subciliary Approach
Status: COMPLETED
Conditions: Zygomatic and Lefort II Fractures|Infraorbital Rim Fixation|Subciliary Approach Repair
Interventions: PROCEDURE: lower eyelid massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participants With Second Line Plus (2L+) Renal Cell Carcinoma (MK-3475-03B)
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Renal Cell
Interventions: BIOLOGICAL: Pembrolizumab|BIOLOGICAL: MK-4830|DRUG: Belzutifan|DRUG: Lenvatinib|BIOLOGICAL: Pembrolizumab/Quavonlimab|BIOLOGICAL: Favezelimab/Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Local Application of Simvastatin Versus Bone Powder on Implant Bone Changes
Status: COMPLETED
Conditions: Dental Caries Extending to Pulp|Dental Implant Failed
Interventions: DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine-esketamine for Percutaneous Radiofrequency Liver Ablation
Status: RECRUITING
Conditions: Liver Cancer|Radiofrequency Ablation|Esketamine|Dexmedetomidine
Interventions: DRUG: Dexmedetomidine-esketamine combination|DRUG: Remifentanil|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Maximal Use Trial Evaluating the Pharmacokinetic Profile of MC2-01 Cream in Adolescent Subjects
Status: TERMINATED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: MC2-01 cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psoas Compartment Block (PCB) Versus L.A Infiltration and Remifentanil Infusion During EVAR
Status: COMPLETED
Conditions: Analgesic Adverse Reaction
Interventions: PROCEDURE: Psoas Compartment Block (PCB)|PROCEDURE: Local Anesthesia infiltration|DRUG: Normal saline 0.9% IV infusion|DRUG: Remifentanil infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: AK-R215 Pharmacokinetic Study Phase I
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: AK-R215|DRUG: Bazedoxifene 20 mg|DRUG: Cholecalciferol 800IU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose Study of BMS-777607 in Subjects With Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: BMS-777607
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycaemic Control of Monthly LAPS-Exendin Versus Placebo in Subjects of Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: HM11260C|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reduction of Cesareans by Nitric Oxide (NO) Donors in Post Term Pregnancies
Status: COMPLETED
Conditions: Prolonged Pregnancy|Nulliparity
Interventions: DRUG: IMN|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate OQL011 on VEGFR Inhibitor-Associated Hand-Foot Skin Reaction in Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Hand-Foot Skin Reaction (HFSR)
Interventions: DRUG: OQL011|DRUG: Vehicle Ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Sock Developed With Wearable Technology for TUR Surgery Patients on Hypothermia and Venous Thromboembolism
Status: WITHDRAWN
Conditions: Transurethral Resection|Wearable Devices|Venous Thromboembolism|Hypothermia|Nurse
Interventions: DEVICE: Socks Developed with Wearable Technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Relationship of Patient-Specific Functional Scale With Shoulder Functions: A Prospective Study
Status: COMPLETED
Conditions: Shoulder Impingement|Frozen Shoulder|Humeral Fractures|Rotator Cuff Tears|Disability Physical|Pain, Shoulder
Interventions: BEHAVIORAL: Shoulder disability|DEVICE: Shoulder Range of Motion|BEHAVIORAL: Pain Intensity
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Charité Trial of Cenicriviroc (CVC) Treatment for COVID-19 Patients
Status: TERMINATED
Conditions: Covid19
Interventions: DRUG: Cenicriviroc (CVC)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Carfilzomib and TGR-1202 in Treatment of R/R Lymphoma
Status: TERMINATED
Conditions: Hodgkin Disease|Lymphoma, Non-hodgkin
Interventions: DRUG: Carfilzomib|DRUG: TGR-1202
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes of the Freedom Spinal Cord Stimulation (SCS) System for the Management of Chronic Back and Leg Pain
Status: TERMINATED
Conditions: Chronic Low Back Pain|Pain in Leg, Unspecified
Interventions: DEVICE: Freedom Spinal Cord Stimulator System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ganciclovir Implant Study for Cytomegalovirus Retinitis
Status: COMPLETED
Conditions: HIV Infections|Acquired Immunodeficiency Syndrome|Cytomegalovirus Retinitis
Interventions: DEVICE: Sustained-Release Intraocular Drug Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Rationale and Design for Shiga Microalbuminuria Reduction Trial
Status: UNKNOWN
Conditions: Hypertension|Diabetes Mellitus|Albuminuria
Interventions: DRUG: Valsartan|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D3 for the Treatment of Low Vitamin D in Cystic Fibrosis
Status: WITHDRAWN
Conditions: Cystic Fibrosis|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coaching and Activity Tracking in Multiple Sclerosis - A Pilot Study
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: OTHER: Activity Monitoring and Symptom Coaching|OTHER: Passive Activity Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Dose-escalation Study of LUNA18 in Patients With Locally Advanced or Metastatic Solid Tumors (With Expansion).
Status: RECRUITING
Conditions: Locally Advanced or Metastatic Solid Tumors
Interventions: DRUG: LUNA18|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Just-in-Time Adaptive Intervention for Child and Family Mental Health
Status: RECRUITING
Conditions: Mental Health and Well-being|Family Functioning
Interventions: BEHAVIORAL: A Just-in-Time Adaptive Intervention for Child and Family Mental Health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Response Prediction in Metastasized Colorectal Cancer Using Intratumoral Thymidylate Synthase
Status: COMPLETED
Conditions: Colorectal Cancer|Non Resectable Metastasis|Reference Lesion|Biopsy|Thymidylate Synthase Quantitation
Interventions: DRUG: FUFA|DRUG: systemic chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of High and Low Tidal Volumes on Arterial Oxygenation and Pulmonary Shunt During One-Lung Ventilation
Status: COMPLETED
Conditions: Postoperative Lung Injury
Interventions: OTHER: high tidal volumes|OTHER: low tidal volume
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Distal Renal Denervation to Prevent Renal Function Decline in Patients With T2DM and Hypertension
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Hypertension
Interventions: PROCEDURE: Anatomically optimized distal renal denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telithromycin, Treating Adult Outpatients With Mild to Moderate Community-acquired Pneumonia (CAP) in High Bacterial Resistance Areas
Status: COMPLETED
Conditions: Pneumonia
Interventions: DRUG: Telithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-dose Postpartum Vitamin A Supplementation of Mothers and Neonates
Status: COMPLETED
Conditions: Vitamin A Deficiency|HIV
Interventions: DRUG: Vitamin A (retinyl palmitate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Silver Diamine Fluoride: A Randomized Controlled Trial on Its Effectiveness As A Caries Arresting Agent
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Caries|Quality of Life
Interventions: OTHER: 38% SDF group|OTHER: 5% NaF group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Combination With Gemcitabine in People With Advanced Mycosis Fungoides or Sézary Syndrome
Status: RECRUITING
Conditions: Mycosis Fungoides|Mycosis Fungoides/Sezary Syndrome|Sezary Syndrome|Sézary|Advanced Mycosis Fungoides
Interventions: DRUG: Gemcitabine|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Colchicine for Reduction of Periprocedural Myocardial Injury in Percutaneous Coronary Intervention
Status: NOT_YET_RECRUITING
Conditions: Periprocedural Myocardial Infarction|Periprocedural Myocardial Injury
Interventions: DRUG: Colchicine Pill
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study of Ketamine Sedation for Aneurysmal Subarachnoid Hemorrhage
Status: WITHDRAWN
Conditions: Subarachnoid Hemorrhage, Aneurysmal
Interventions: DRUG: Ketamine Hydrochloride|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Repetitive Transcranial Magnetic Stimulation for Refractory Auditory Hallucinations in Schizophrenia
Status: COMPLETED
Conditions: Refractory Schizophrenia
Interventions: DEVICE: repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Three Chemo Regimens as an Adjunct to ART for Treatment of Advanced AIDS-KS
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Etoposide (ET)|DRUG: Bleomycin and Vincristine (BV)|DRUG: Paclitaxel (PTX)|DRUG: Co-formulated Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate (EFV/FTC/TDF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Predictive Biomarkers for Immune-Related Adverse Events (irAEs) in Patients Undergoing Immune CheckPoint Inhibitors (ICPI) Treatment
Status: RECRUITING
Conditions: Immunotherapy|Immune Checkpoint Inhibitors|Immune-related Adverse Event|Predictive Biomarkers
Interventions: BIOLOGICAL: blood retriewal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: "A Clinical Study for Evaluating the Effect of a Plant Sterol-enriched Fermented Dairy Product on Blood Lipoprotein Profile in Japanese Adults"
Status: COMPLETED
Conditions: Subjects With High LDL-Cholesterol
Interventions: OTHER: 1-Fermented Dairy Product with Phytosterols (test)|OTHER: 2-Fermented dairy Product with No Phytosterols (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Lateral Ankle Ligament Reconstruction With InternalBrace™ Augmentation
Status: UNKNOWN
Conditions: Lateral Ankle Instability
Interventions: DEVICE: Modified Brostrum procedure with Internal Brace Augmentation|DEVICE: Modified Brostrum procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of TAK-981 Given With Monoclonal Antibodies (mAbs) In Adults With Relapsed or Refractory Multiple Myeloma (RRMM)
Status: TERMINATED
Conditions: Relapsed and/or Refractory Multiple Myeloma (RRMM)
Interventions: DRUG: TAK-981|DRUG: Mezagitamab|DRUG: Daratumumab and Hyaluronidase-fihj
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DIC Markers and Thrombin Generation Parameters in Patients on ECMO Support: a Pilot Study
Status: RECRUITING
Conditions: Extracorporeal Circulation; Complications|Extracorporeal Membrane Oxygenation Complication
Interventions: DIAGNOSTIC_TEST: DIC markers and Thrombin Generation Parameters
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Automated Oxygen Titration Alone or With High Flow Nasal Therapy on Dyspnea and Exercise Tolerance
Status: TERMINATED
Conditions: Dyspnea|Lung Diseases|Pulmonary Hypertension|Chronic Obstructive Pulmonary Disease|Cystic Fibrosis|Interstitial Lung Disease
Interventions: DEVICE: Automated nasal O2 titration with FreeO2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Endothelial Disfunction Treatment With Glimepiride/Metformin Combination (Glimetal) in Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Endothelial Dysfunction|Diabetes Mellitus
Interventions: DRUG: Glimepiride/metformin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Perpetrator DDI Potential of Givinostat as Inhibitor and Inducer of CYP3A and P-gp Activity
Status: COMPLETED
Conditions: Drug-Drug Interaction
Interventions: DRUG: ITF2357 Givinostat 10mg/mL|DRUG: Midazolam 1Mg/Ml (Pf) Inj Syringe 5Ml|DRUG: Midazolam Oral Liquid Product|DRUG: Dabigatran Etexilate 75 MG [Pradaxa]|DRUG: Clarithromycin 500Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of Hypofractionated Proton Therapy for Stage II-III Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Neoplasms
Interventions: RADIATION: Radiation with Concurrent Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemoprophylaxis With Rivaroxaban for Lower Limb Deep Vein Thrombosis in Colorectal Cancer
Status: UNKNOWN
Conditions: Deep Venous Thrombosis|Colonic Cancer
Interventions: DRUG: Rivaroxaban 10 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bupropion for Hospitalized Smokers With Acute Cardiovascular Disease
Status: COMPLETED
Conditions: Smoking|Myocardial Infarction|Unstable Angina|Cardiovascular Disease
Interventions: DRUG: bupropion SR (sustained-release)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Maintaining Patency in Implanted Port Catheters
Status: COMPLETED
Conditions: Obstruction; Catheter, Infusion Catheter (Vascular)|Catheter; Complications (Indwelling Catheter)
Interventions: OTHER: Heparinized saline catheter flush|OTHER: Saline-only catheter flush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Antipyretic Treatment in Children Receiving Pneumococcal Conjugate and Standard Infant Vaccines
Status: COMPLETED
Conditions: Infections, Rotavirus
Interventions: BIOLOGICAL: 10 valent pneumococcal conjugate vaccine|BIOLOGICAL: Infanrix Hexa|BIOLOGICAL: Rotarix|DRUG: Paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability of Intravenous Fish Oil Lipid Emulsion in Children Undergoing Hematopoietic Cell Transplantation
Status: COMPLETED
Conditions: Hematopoietic Stem Cell Transplantation
Interventions: DRUG: Omegaven|DRUG: Soybean oil lipid emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Self-help for Treating Social Anxiety Disorder: An Evaluation of a Mindfulness and Acceptance-based Approach
Status: COMPLETED
Conditions: Anxiety|Shyness
Interventions: OTHER: The Mindfulness and Acceptance-based Workbook for Social Anxiety and Shyness (Fleming & Kocovski, 2013)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radioligand Therapy After PSMA PET Guided External Beam Radiotherapy for Treating Post-Prostatectomy Patients With Biochemically Recurrent Prostate Cancer
Status: RECRUITING
Conditions: Biochemically Recurrent Prostate Carcinoma|Prostate Adenocarcinoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|RADIATION: External Beam Radiation Therapy|OTHER: Flotufolastat F-18|DRUG: Lutetium Lu 177 PSMA-10.1|PROCEDURE: Positron Emission Tomography|PROCEDURE: Single Photon Emission Computed Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial Of Omeprazole in Idiopathic Pulmonary Fibrosis (IPF)
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Omeprazole|DRUG: Matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Ranibizumab (Lucentis) for Uveitic Cystoid Macular Edema
Status: COMPLETED
Conditions: Uveitic Cystoid Macular Edema
Interventions: DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Benfluorex Versus Metformin on Glucose Control and Insulin Secretion in Chinese Type 2 Diabetic Patients
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: metformin|DRUG: benfluorex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of a Family Counseling Intervention ("Tuko Pamoja") in Kenya
Status: NOT_YET_RECRUITING
Conditions: Mental Health Issue|Family Relations|Family Conflict|Child Mental Disorder|Adolescent - Emotional Problem|Adolescent Problem Behavior|Child Behavior|Child Abuse|Marital Conflict|Domestic Violence|Parent-Child Relations|Parenting
Interventions: BEHAVIORAL: Tuko Pamoja, "We are Together" in Kiswahili
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety, Efficacy and Pharmacokinetics of Glycerol Phenylbutyrate in Pediatric Subjects Under 2 Years of Age With Urea Cycle Disorders
Status: COMPLETED
Conditions: Urea Cycle Disorder
Interventions: DRUG: RAVICTI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short-Term Efficacy of Triamcinolone Acetonide (Aristocort® C) in Subjects With Atopic Dermatitis
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: Triamcinolone Acetonide (Aristocort® C)|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Novel Nitroglycerin Based Catheter Lock Solution
Status: COMPLETED
Conditions: Catheter-Associated Infections|Catheter-Related Infections
Interventions: DRUG: Nitroglycerin-citrate-ethanol (NiCE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Patient Narcotic Requirements After Outpatient Otolaryngology Procedures
Status: COMPLETED
Conditions: Outpatient Surgery|Pain, Postoperative
Interventions: DRUG: Norco|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Hyperthermia and Concurrent Chemoradiotherapy (CCRT) in Treatment Failure Solid Tumors
Status: WITHDRAWN
Conditions: Solid Tumors
Interventions: RADIATION: Radiation|OTHER: Hyperthermia|DRUG: Cisplatin|DRUG: Taxotere
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Absolute Bioavailability (ABA) of TAK-906 and to Characterize Mass Balance, Pharmacokinetics (PK), Metabolism, and Excretion of [14C]-TAK-906 in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: TAK-906 Oral Capsule|DRUG: [14C]-TAK-906 Intravenous Infusion|DRUG: [14C]-TAK-906 Oral Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Management of Insomnia in Breast Cancer Patients
Status: COMPLETED
Conditions: Insomnia|Fatigue
Interventions: BEHAVIORAL: BBT-I|BEHAVIORAL: Control|DRUG: Armodafinil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Valerian Root Extract and Lavender Essential Oil Combination, Over 4 Weeks in Subjects With Sleep Complaints
Status: COMPLETED
Conditions: Sleep
Interventions: DIETARY_SUPPLEMENT: Valerian - lavender|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Quetiapine Fumarate in the Treatment of Schizophrenic Patients
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Quetiapine Fumarate (SEROQUEL) Extended-Release (XR)|DRUG: Chlorpromazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FeetEnergy Approach to Increase Physical Activity and Reduce Screen Time in Adolescents
Status: COMPLETED
Conditions: Physical Activity|Sedentary Behavior|Active Commuting|Psychosocial Factors|Parental Interference
Interventions: BEHAVIORAL: Internet-supported FeetEnergy approach|BEHAVIORAL: Usual health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Analgesic Effect of Different Positions and Canulae on Medial Branch Radiofrequency Denervation for Lumbar Zygapophyseal Joint Pain
Status: COMPLETED
Conditions: Lumbar Facet Joint Pain|Lumbar Medial Branch Neurotomy
Interventions: OTHER: PAIN REDUCTION ON VAS/NRS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Pre-operative Oral Hydration on Post-operative Pain and Nausea in Adults Undergoing Tonsillectomy
Status: WITHDRAWN
Conditions: Tonsil Disease|Surgical Wound|Pain, Postoperative
Interventions: OTHER: Oral water and clear liquids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Essential Oil Mouthwash With and Without Alcohol: a 3-Day Plaque Accumulation Model
Status: COMPLETED
Conditions: Gingivitis|Periodontitis
Interventions: OTHER: free alcohol essential oil mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: HH-120 Nasal Spray for Post-exposure Prevention of SARS-CoV-2
Status: RECRUITING
Conditions: COVID-19
Interventions: DRUG: HH-120 Nasal Spray|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Apidra to Regular Insulin in Hospitalized Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type II
Interventions: DRUG: Glulisine (Apidra)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ofatumumab In Older Patients With Untreated Low Or Intermediate Risk Indolent B-Cell Lymphomas
Status: WITHDRAWN
Conditions: Lymphoma, Non-Hodgkin|Lymphoma, Follicular|Lymphoma, B-Cell, Marginal Zone|Lymphoma, Low-Grade|Lymphoma, Intermediate-Grade
Interventions: DRUG: Ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapy
Status: RECRUITING
Conditions: Pulmonary Embolism
Interventions: DRUG: Anticoagulant Therapy|DEVICE: Catheter-Directed Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expanded Access Program of Sofosbuvir With Ribavirin and With or Without Pegylated Interferon in Aggressive Post-transplant Hepatitis C
Status: APPROVED_FOR_MARKETING
Conditions: Post-transplant Hepatitis C
Interventions: DRUG: Sofosbuvir|DRUG: Ribavirin|DRUG: Pegylated Interferon
Study Type: EXPANDED_ACCESS
Clinical trial: A Pilot Study of Lactofiltrum to Treat Atopic Dermatitis in Adults
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Lactofiltrum|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Mechanical Insufflation-exsufflation and Hypertonic Saline
Status: COMPLETED
Conditions: Endotracheal Tube|Tracheostomy
Interventions: DEVICE: Catheter secretion suctioning|COMBINATION_PRODUCT: Secretion suctioning + hypertonic saline|DEVICE: Ins-exsufflation|COMBINATION_PRODUCT: Ins-exsufflation + Hypertonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: T-DXd Therapy for HER2-low Breast Cancer Patients With Brain Metastases
Status: RECRUITING
Conditions: Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: Trastuzumab-Deruxtecan (T-DXd)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Tooth-borne Expanders in Rapid Maxillary Expansion
Status: COMPLETED
Conditions: Malocclusion|Posterior Crossbite
Interventions: DEVICE: Hyrax|DEVICE: mini Hyrax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability,Safety,Pharmacokinetic Profile and Immunogenicity of a Recombinant Humanized Anti-SARS-CoV-2 Monoclonal Antibody (JS016) for Injection in Chinese Health Subjects
Status: UNKNOWN
Conditions: COVID-19; and High Infection Risk of SARS-CoV-2
Interventions: COMBINATION_PRODUCT: JS016 (anti-SARS-CoV-2 monoclonal antibody)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Anesthesia With Propofol Versus Desflurane in Obese Patients
Status: COMPLETED
Conditions: Anesthesia|Obesity
Interventions: DRUG: Desflurane Inhalant Product|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Compassion-Based Resiliency Training (CBRT) Intervention on Racism-based Stress
Status: RECRUITING
Conditions: Racism|Stress, Psychological
Interventions: BEHAVIORAL: Contemplative-Based Resilience Training (CBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Short-term Curcumin and Multi-polyphenol Supplementation on the Anti-inflammatory Properties of HDL
Status: COMPLETED
Conditions: Inflammation|Atherosclerosis|Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: PolyResveratrol Supplementation|DIETARY_SUPPLEMENT: Curcumin Supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Residual Refraction Errors 6 Months After Trifocal IOL Implantation With Relex-Smile
Status: ENROLLING_BY_INVITATION
Conditions: Pseudophakia|Myopia|Hyperopia
Interventions: PROCEDURE: Relex Smile|PROCEDURE: Relex smile with fresh corneal lenticule implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Training in Inpatient Treatment for Substance Use Disorders
Status: COMPLETED
Conditions: Substance Use Disorders
Interventions: BEHAVIORAL: Cognitive training activities|BEHAVIORAL: Inpatient psychosocial therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Renal Tubular Injury and Transplant Outcomes in Cardiac Recipients Converting From IR Tacrolimus to XR Tacrolimus
Status: RECRUITING
Conditions: Chronic Kidney Diseases|Heart Transplant
Interventions: DRUG: Conversion from IR Tacrolimus to XR Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages
Status: RECRUITING
Conditions: Eosinophilic Gastrointestinal Disorders (EGIDs)|Eosinophilic Esophagitis|Eosinophilic Gastritis|Eosinophilic Gastroenteritis|Eosinophilic Colitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT)
Status: RECRUITING
Conditions: Traumatic Brain Injury
Interventions: DIAGNOSTIC_TEST: Full-band Electrocorticography|COMBINATION_PRODUCT: Treatment Algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surveillance, Prevention and Treatment of Intra-abdominal Hypertension and Abdominal Compartment Syndrome
Status: UNKNOWN
Conditions: Intra-Abdominal Hypertension|Abdominal Compartment Syndrome
Interventions: DIAGNOSTIC_TEST: Intra-abdominal Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Anesthetic Technique on Immune and Inflammatory Systems Following Radical Prostatectomy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Patient controlled analgesia (PCA)|DRUG: Thoracic Epidural Analgesia (TEA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lohp, 5-Fu/Lv and Bevacizumab, Alternative With Cpt-11, 5-Fu/Lv and Cetuximab In Metastatic Crc
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: Oxaliplatin|DRUG: 5-Fluorouracil|DRUG: Leucovorin|DRUG: Bevacizumab|DRUG: Irinotecan|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Nutrition Supplementation on Treatment Efficiency and Hemodynamics During Dialysis
Status: COMPLETED
Conditions: Blood Pressure|Kidney Failure, Chronic|Dietary Modification
Interventions: DIETARY_SUPPLEMENT: Nepro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PrEP and MOUD Rapid Access for Persons Who Inject Drugs: The CHORUS+ Study
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder
Interventions: BEHAVIORAL: CHORUS+|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single and Multiple Ascending Dose Study of Aducanumab (BIIB037) in Japanese Participants With Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Aducanumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exploring an Incubator to Decrease Stress in Farmers Occupational Stress and Depression in Beginning Kentucky Farmers
Status: COMPLETED
Conditions: Occupational Stress|Depression
Interventions: BEHAVIORAL: Virtual Community of Support|BEHAVIORAL: Mentorship Incubator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: R-BL-M-04 Versus R-(DA)-EPOCH and Autologous Stem Cells Transplantation in Patients With High-Grade B-cell Lymphoma Double-hit (HGBL DH) and High-Grade B-cell Lymphoma Not Otherwise Specified (HGBL NOS)
Status: UNKNOWN
Conditions: Lymphoma, High-Grade
Interventions: DRUG: R-DA-EPOCH-21|DRUG: R-BL-M-04|DRUG: R-DA-EPOCH-21 + auto-SCT|DRUG: R-BL-M-04 + auto-SCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AngelMed for Early Recognition and Treatment of STEMI
Status: COMPLETED
Conditions: Acute Myocardial Infarction (AMI)|Coronary Occlusion|Acute Coronary Syndrome
Interventions: DEVICE: Guardian System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Multicenter Trial of ESK981 in Patients With Select Solid Tumors
Status: RECRUITING
Conditions: Pancreatic Adenocarcinoma|Adenosquamous Carcinoma|Pancreatic Neuroendocrine Tumor|Pancreatic Neuroendocrine Carcinoma|Gastrointestinal Neuroendocrine Tumor|Gastrointestinal Neuroendocrine Carcinoma|Neuroendocrine Prostate Carcinoma
Interventions: DRUG: ESK981
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Ultrasound Guided Ozone and Lidocaine Injections in Piriformis Syndrome
Status: RECRUITING
Conditions: Piriformis Syndrome
Interventions: OTHER: Ozone|DRUG: Lidocain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: First in Human Study to Assess the Safety and the Efficacy of an Implantable Nitinol Device in the Treatment of Keratoconus
Status: RECRUITING
Conditions: Keratoconus
Interventions: DEVICE: Intracorneal implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thrust Joint Manipulation and Reverse SNAGS (Sustained Natural Apophyseal Glides) in Cervicogenic Headache
Status: COMPLETED
Conditions: Cervicogenic Headache
Interventions: OTHER: Thrust Joint Manipulation|OTHER: Reverse Sustained Natural apophyseal glides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aerobic Exercise Training in Amyotrophic Lateral Sclerosis
Status: UNKNOWN
Conditions: Amyotrophic Lateral Sclerosis
Interventions: OTHER: Aerobic exercise training|OTHER: Standard physical therapy (Stretching/Range-of-motion)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE