pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: SIMBRINZA® Suspension BID as an Adjunctive to Prostaglandin Analogue (PGA)
Status: COMPLETED
Conditions: Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Brinzolamide 1%/brimonidine 0.2% tartrate ophthalmic suspension|DRUG: Brinz/brim vehicle|DRUG: Prostaglandin analogue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Emtricitabine and Stavudine Used With Didanosine Plus Efavirenz in HIV-Infected Patients Who Have Not Taken Anti-HIV Drugs
Status: UNKNOWN
Conditions: HIV Infections
Interventions: DRUG: Efavirenz|DRUG: Emtricitabine|DRUG: Stavudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A First in Human Study of the Safety and Tolerability of Single and Multiple Doses of SPR206 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: SPR206|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of KN057 Prophylaxis in Patients With Haemophilia A or B Without Inhibitors
Status: RECRUITING
Conditions: Hemophilia A Without Inhibitor|Hemophilia B Without Inhibitor
Interventions: DRUG: KN057
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Premature Aging and Type 2 Diabetes Mellitus: an Increased Risk of Cardiomyopathy?
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: Cardiac RMI|OTHER: Analysis telomere|OTHER: Stress test|OTHER: echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Effect of a Combination of Plant Extracts (BSL_EP027) on the Incidence of Respiratory Infections
Status: COMPLETED
Conditions: Immune Response|Respiratory Diseases
Interventions: COMBINATION_PRODUCT: Combination of plant extracts (BSL_EP027)|COMBINATION_PRODUCT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Cholesterol-lowering Probiotic Lactobacillus Plantarum LPLDL® in Hypercholesterolemic Adults.
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: Lactobacillus plantarum ECGC 13110402|DIETARY_SUPPLEMENT: Placebo Comparator: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of Applications of the ® PillCam Endoscopy System and Evaluation of Their Performance
Status: COMPLETED
Conditions: Any Gastric Condition Which Requires Capsule Endoscopy
Interventions: DEVICE: Pillcam endoscopy system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Photobiomodulation Therapy Using the Realief Therapy System for the Treatment of Chemotherapy-associated Peripheral Neuropathy
Status: COMPLETED
Conditions: Chemotherapy-induced Peripheral Neuropathy
Interventions: DEVICE: photobiomodulation|OTHER: Sham treatment|OTHER: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Effect of Coronavac Vaccine (Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 Vaccine) on Healthcare Workers' Menstrual Patterns
Status: COMPLETED
Conditions: Covid19|Vaccine Reaction|Coronavirus|Menstrual Problem|Endometrium
Interventions: OTHER: healthcare workers with the coronavac vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of NMN Supplementation on Organ System Biology
Status: RECRUITING
Conditions: Glucose Metabolism Disorders
Interventions: OTHER: Placebo|DIETARY_SUPPLEMENT: Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Eltrombopag for the Treatment of Thrombocytopenia Due to Low- and Intermediate Risk Myelodysplastic Syndromes
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelodysplastic Syndromes|Thrombocytopenia
Interventions: DRUG: Eltrombopag/Revolade|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: DIABGAD - Trial to Preserve Insulin Secretion in Type 1 Diabetes Using GAD-Alum (Diamyd) in Combination With Vitamin D and Ibuprofen
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: BIOLOGICAL: GAD-Alum (Diamyd) 20 µg|BIOLOGICAL: GAD-Alum (Diamyd) 20 µg X 2|DRUG: Vitamin D|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MF101 in Postmenopausal Women
Status: UNKNOWN
Conditions: Hot Flushes|Vasomotor Symptoms
Interventions: DRUG: MF101 5 g/day|DRUG: Placebo|DRUG: MF101 10 g/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3844583 in Healthy Participants and Participants With Atopic Dermatitis
Status: TERMINATED
Conditions: Healthy|Dermatitis, Atopic
Interventions: DRUG: LY3844583|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of the Efficacy of Calcium Dobesilate vs. Placebo on SARS-CoV-2 Viral Load Amongst Outpatients With COVID-19.
Status: COMPLETED
Conditions: COVID-19 Virus Disease
Interventions: DRUG: Calcium Dobesilate|DRUG: Mannitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Donor-derived CD19 CAR Therapy Bridged Allo-HSCT and Sequential Donor-derived CD22 CAR Therapy for r/r B-ALL: a Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: B-cell Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia, in Relapse
Interventions: DRUG: Donor-derived CD19 CAR Therapy Bridged Allo-HSCT and Sequential Donor-derived CD22 CAR Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketone Supplementation in Eating Disorders
Status: RECRUITING
Conditions: Anorexia Nervosa|Bulimia Nervosa|Atypical Anorexia Nervosa|Atypical Bulimia Nervosa
Interventions: DIETARY_SUPPLEMENT: Kenetik Ketone Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy
Status: COMPLETED
Conditions: Aggressive Periodontitis
Interventions: OTHER: Photodynamic Therapy|OTHER: Sham Photodynamic Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of an Intervention Program by Proprioceptive Neuromuscular Facilitation, in Muscle Force Irradiation.
Status: UNKNOWN
Conditions: Assessment of Muscle Force Irradiation
Interventions: OTHER: Proprioceptive Neuromuscular Facilitation - PNF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Long-Term Safety of Ustekinumab Versus Other Biologics in Patients With Crohn's Disease and Ulcerative Colitis
Status: RECRUITING
Conditions: Crohn Disease|Colitis, Ulcerative
Interventions: DRUG: Ustekinumab|DRUG: Other Biologic Therapies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Learn What Happens to Elinzanetant in the Body When Taken With or Without Carbamazepine, and How Safe it is in Healthy Men and Women Aged 18 to 60 Years.
Status: COMPLETED
Conditions: Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men
Interventions: DRUG: Elinzanetant (BAY3427080)|DRUG: Midazolam|DRUG: Carbamazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dose Exploration of Ciprofol for Sedation in Gastrointestinal Endoscopic Diagnosis and Treatment of Obese Patients.
Status: RECRUITING
Conditions: Gastric Cancer|Gastric Ulcer|Intestinal Polyps|Intestinal Cancer
Interventions: DRUG: ciprofol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intraoperative Anesthetic Management on Postoperative Nausea and Vomiting in Bariatric Surgery
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: TIVA NoNarc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Soft Silicone Wound Contact Layer Containing Silver in the Treatment of Skin Grafts in Surgical Burn Patients.
Status: COMPLETED
Conditions: Burn Injury|Skin Graft
Interventions: DEVICE: Mepitel® Ag|DEVICE: Mepilex® Transfer Ag
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Chemoradiotherapy in Patients With Refractory Pituitary Adenomas
Status: UNKNOWN
Conditions: Pituitary Adenomas
Interventions: DRUG: Radiotherapy plus temozolomide|OTHER: Radiotherapy plus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Brain Stimulation in Mild Cognitive Impairment and Dementia
Status: COMPLETED
Conditions: Alzheimer Disease|Mild Cognitive Impairment|Dementia
Interventions: DEVICE: Active Transcranial direct current stimulation (STARStim 8)|DEVICE: Active Transcranial direct current stimulation (STARStim 8)|DEVICE: Sham Transcranial direct current stimulation (STARStim 8)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Different Treatments for the Intensive Care Unit Acquired Weakness
Status: COMPLETED
Conditions: Muscle Weakness|Rehabilitation
Interventions: DEVICE: neuro muscular electro stimulation|OTHER: Early Mobilization protocol|OTHER: standard care or usual rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Online Exercise Program and Dietary Advice (FITT-online) for Children and Adolescents With Obesity
Status: RECRUITING
Conditions: Obesity
Interventions: BEHAVIORAL: Online program that includes exercise guided by the FITT-VP principle and dietary advice|BEHAVIORAL: Conventional in-clinic nutrition and exercise advice and self-control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of the Subglottic Secretions Drainage on the Tracheal Secretions Colonisation
Status: COMPLETED
Conditions: Ventilator-associated Pneumonia
Interventions: DEVICE: Endotracheal tubes not allowing SSD|DEVICE: Endotracheal tubes allowing SSD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Serp-1 for the Treatment of Acute Coronary Syndrome
Status: TERMINATED
Conditions: Unstable Angina|Coronary Atherosclerosis|Coronary Restenosis
Interventions: DRUG: Serine proteinase-1 (Serp-1)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Caudal Epidural Block on Intraoperative Blood Loss During Hypospadias Repair
Status: COMPLETED
Conditions: Hypospadias
Interventions: DRUG: Bupivacaine|PROCEDURE: General anesthesia|DRUG: Dilute epinephrine injection|DRUG: Fentanyl|DRUG: dextrose plus sodium chloride.|DRUG: neostigmine and atropine|PROCEDURE: Hypospadias repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Absorption of Paracetamol, Talinolol and Amoxicillin After Oral Administration Using Non-caloric and Caloric Water
Status: COMPLETED
Conditions: Gastrointestinal Motility Disorder
Interventions: DRUG: Acetaminophen|DRUG: Talinolol|DRUG: Amoxicillin|OTHER: non-caloric water|OTHER: caloric water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Healthy Immigrant Families: Working Together To Move More and To Eat Well
Status: COMPLETED
Conditions: Immigrant Physical Activity and Nutrition
Interventions: BEHAVIORAL: Face-to-face family mentoring and education sessions|BEHAVIORAL: Telephone follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bottle PEP in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: OTHER: Bottle-PEP|OTHER: Routine physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cognitive Behavioral Therapy (REBT/CBT) Evaluation for Dysthymia in the Practice of Clinical Social Work at Primary Care
Status: COMPLETED
Conditions: Depression|Dysthymia|Ambulatory Health Services
Interventions: OTHER: Rational-Emotive-Behavioral Therapy|OTHER: Control Group usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential HIV Therapy in Treatment Resistant HIV-1 Infected Patients
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: Standard Continuous Highly Active Antiretroviral Therapy (HAART)|DRUG: Rapidly Cycled HAART
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Daratumumab and Ibrutinib in Treating Patients With Symptomatic Chronic Lymphocytic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: Daratumumab|DRUG: Ibrutinib|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stage I HER2 Positive Invasive Breast Cancer De-escalation Study(IRIS-C/D)
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: capecitabine and trastuzumab|DRUG: vinorelbine and trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Weekly Ixabepilone for High Risk, Clinically Localized Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Ixabepilone|PROCEDURE: Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Relational Artificial Intelligence (AI) Chatbot for App-Based Physical Activity Promotion
Status: ACTIVE_NOT_RECRUITING
Conditions: Behavior, Health
Interventions: BEHAVIORAL: Non-Relational Chatbot Physical Activity Intervention|BEHAVIORAL: Relational Chatbot Physical Activity Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Intracranial Pressure During Mechanical Ventilation Recruitment Maneuver
Status: COMPLETED
Conditions: Effect of Recruitment Maneuver on Intracranial Pressure
Interventions: DIAGNOSTIC_TEST: The recruitment maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Postoperative Adjuvant Chemotherapy for Thymic Cancer (FUSCC-Thymic 3)
Status: RECRUITING
Conditions: Thymic Carcinoma
Interventions: DRUG: Chemotherapy|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine in Children
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: FluLaval® Quadrivalent|BIOLOGICAL: Havrix™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I Safety and Tolerability Study of Birinapant in Chronic Hepatitis B
Status: TERMINATED
Conditions: Hepatitis B
Interventions: DRUG: Antiviral Therapy (tenofovir or entecavir)|DRUG: Birinapant|DRUG: Placebo (for birinapant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 11C- and 18F-Choline PET/MR Imaging for Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Carbon C 11 Choline|DRUG: Fluorine F 18 Choline|PROCEDURE: Positron Emission Tomography (PET) / Magnetic Resonance Imaging (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bupropion Hydrochloride or Patient's Choice for Smoking Cessation in Patients With Squamous Cell Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy
Status: TERMINATED
Conditions: Current Smoker|Head and Neck Squamous Cell Carcinoma|Hypopharyngeal Squamous Cell Carcinoma|Laryngeal Squamous Cell Carcinoma|Nasopharyngeal Carcinoma|Oral Cavity Squamous Cell Carcinoma|Oropharyngeal Squamous Cell Carcinoma
Interventions: DRUG: Bupropion Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Nicotine Replacement|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: Varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity and Safety of A Group A, C Polysaccharide Meningococcal and Type b Haemophilus Influenzal Conjugate Vaccine in Infants and Children
Status: COMPLETED
Conditions: Group A, C Polysaccharide Meningitis|Type b Haemophilus Influenza
Interventions: BIOLOGICAL: A+C+hib Conjugate Vaccine|BIOLOGICAL: Placebo|BIOLOGICAL: A+C Vaccine|BIOLOGICAL: Hib vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Trial of One Versus Two Doses of Dexamethasone for Pediatric Asthma Exacerbation
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Dexamethasone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease
Status: TERMINATED
Conditions: Sickle Cell Disease
Interventions: DRUG: Aes-103|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Adebrelimab and Chemotherapy in High-rish ER+/HER2- BC
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Adebrelimab combined with nab-paclitaxel, epirubicin and cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-time Sensorimotor Feedback for Injury Prevention Assessed in Virtual Reality
Status: COMPLETED
Conditions: Injury of Anterior Cruciate Ligament
Interventions: OTHER: aNMT Biofeedback|OTHER: Sham Biofeedback|OTHER: Neuromuscular Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Safety and Efficacy Study of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-Severe Symptom State
Status: RECRUITING
Conditions: Sjögren's Syndrome (SS)
Interventions: DRUG: Dazodalibep|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Plant Protein Isolate on Muscle Protein Synthesis in Humans at Rest and After Resistance Exercise
Status: COMPLETED
Conditions: Metabolism|Exercise|Dietary Supplements
Interventions: DIETARY_SUPPLEMENT: NEAA|DIETARY_SUPPLEMENT: PPI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Circadian Disturbances After Breast Cancer Surgery
Status: COMPLETED
Conditions: Circadian Rhythm Disorders|Anxiety|Breast Cancer
Interventions: DEVICE: Wrist-Actigraph - Octagonal Basic Motionlogger, Ambulatory monitoring Inc, New York, USA|DEVICE: Polysomnograph - Embla A10 (Medcare, Reykjavik, Iceland)|DEVICE: Holter monitor - Medilog AR12 (Oxford Instruments, Oxford, England)|PROCEDURE: Urine 6-sulphatoxymelatonin (aMT6s)|OTHER: Karolinska Sleepiness Scale|OTHER: Visual Analog Scale and 10 point-scales to measure fatigue, general well-being, subjective sleep and pain|OTHER: Sleep-diary
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pan FGFR Kinase Inhibitor BGJ398 and Combination Chemotherapy in Treating Patients With Untreated Metastatic Pancreatic Cancer
Status: WITHDRAWN
Conditions: Colon Adenocarcinoma|Metastatic Pancreatic Adenocarcinoma|Pancreatic Adenocarcinoma|Pancreatic Ductal Adenocarcinoma|Rectal Adenocarcinoma|Stage III Pancreatic Cancer|Stage IIIA Colon Cancer|Stage IIIA Rectal Cancer|Stage IIIB Colon Cancer|Stage IIIB Rectal Cancer|Stage IIIC Colon Cancer|Stage IIIC Rectal Cancer|Stage IV Pancreatic Cancer|Stage IVA Colon Cancer|Stage IVA Rectal Cancer|Stage IVB Colon Cancer|Stage IVB Rectal Cancer
Interventions: DRUG: Fluorouracil|DRUG: Irinotecan Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Oxaliplatin|DRUG: pan FGFR Kinase Inhibitor BGJ398|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intraoperative Magnesium Sulfate Infusion on the Postoperative Recovery
Status: TERMINATED
Conditions: Postoperative Pain
Interventions: DRUG: Magnesium Sulfate|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Orexin and Tau Pathology in Cognitively Normal Elderly
Status: COMPLETED
Conditions: Elderly|Alzheimer Disease
Interventions: PROCEDURE: Actigraphy|PROCEDURE: Nocturnal Polysomnograpahy (NPSG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Potential for Adrenal Suppression Following Treatment With DSXS in Patients With Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: DSXS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastroprotected Superoxide Dismutase in Combination With UVB vs Placebo and UVB for Treating Vitiligo.
Status: COMPLETED
Conditions: Vitiligo
Interventions: DRUG: Glisodin tablet|DRUG: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Fluoroscopy-free Technique During Retrograde Intrarenal Surgery for Renal Stones
Status: RECRUITING
Conditions: Kidney Calculi|Radiation Exposure|Retrograde Intrarenal Surgery
Interventions: PROCEDURE: Fluoroscopy-free RIRS|PROCEDURE: Standard RIRS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chantix for Treating Cocaine Dependence
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: varenicline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treating Patients With Melanoma and ALK Alterations With Ensartinib
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: DRUG: Ensartinib|DIAGNOSTIC_TEST: ALKATI by Customized Nanostring Assay
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Lightweight Mesh Repair of Large Hiatal Hernias
Status: UNKNOWN
Conditions: Hernia, Hiatal
Interventions: PROCEDURE: Laparoscopic hiatal repair with sub-lay partially absorbable lightweight mesh|PROCEDURE: Laparoscopic primary posterior crural repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Application of CPAP to Reduce Complications and Improve Lung Cancer Ablation Radiofrequency Treatment
Status: COMPLETED
Conditions: Atelectasis|Lung Cancer
Interventions: DEVICE: RESMED AUTOSET S9
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Cabozantinib in Patients With RET Fusion-Positive Advanced Non-Small Cell Lung Cancer and Those With Other Genotypes: ROS1 or NTRK Fusions or Increased MET or AXL Activity
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Have a History of Inadequate Response to or Intolerance to at Least One Disease Modifying Anti-Rheumatic Drug (DMARD) Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Psoriatic Arthritis
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: Risankizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Combined Energy and Carbohydrate Restriction on Exercise Capacity
Status: RECRUITING
Conditions: Overweight and Obesity
Interventions: OTHER: Calorie-restriction with low carbohydrate|OTHER: Calorie-restriction with moderate carbohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First-in-human Study of HyperQureTM", Laparoscopic Renal Denervation Therapy in Patient With Resistant Hypertension
Status: RECRUITING
Conditions: Resistant Hypertension
Interventions: DEVICE: HyperQure Renal Denervation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Ultrasound-guided Transverses Abdominis Plane Block in Inguinal Herniorrhaphy: Randomized Controlled Clinical Trial
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: TAP block with Bupivacaine at 0.25%|DRUG: Placebo saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improved Delivery of Cardiovascular Care Through Outreach Facilitation
Status: COMPLETED
Conditions: Hypertension|Dyslipidemia|Diabetes|Chronic Kidney Disease|Cardiovascular Disease|Stroke|Transient Ischemic Attacks
Interventions: OTHER: Outreach Facilitation implementing elements of the Chronic Care Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Safety and Efficacy Study of Relamorelin in Diabetic Gastroparesis 01
Status: TERMINATED
Conditions: Gastroparesis|Diabetes Mellitus
Interventions: DRUG: Placebo|DRUG: Relamorelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Food Study of Propranolol Hydrochloride Extended-Release Capsules 160 mg and Inderal® LA Capsules 160 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Propranolol Hydrochloride Extended-Release Capsules 160 mg|DRUG: Inderal® LA Capsules 160 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Evaluate Safety and Effectiveness of Lenalidomide in Combination With Docetaxel and Prednisone for Patients With Castrate-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Lenalidomide|DRUG: Docetaxel|DRUG: Prednisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Weekly Cisplatin or Nedaplatin Concurrent With Intensity-modulated Radiation Therapy in Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Nedaplatin|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pregnancy and Chronic Disease: The Effect of a Midwife-coordinated Maternity Care Intervention
Status: COMPLETED
Conditions: Chronic Diseases in Pregnancy
Interventions: BEHAVIORAL: ChroPreg + standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Tracheostomy Granulomas
Status: COMPLETED
Conditions: Granuloma|Tracheostomy
Interventions: DRUG: Betadine|DRUG: Silver Nitrate|DRUG: Hydrocortisone Butyrate Cream, 1.0%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Pioglitazone on Endothelial Function in Premenopausal Women With Uncomplicated Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: pioglitazone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Study of Emixustat Hydrochloride in Subjects With Macular Atrophy Secondary to Stargardt Disease
Status: COMPLETED
Conditions: Stargardt Disease|Macular Atrophy
Interventions: DRUG: Emixustat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Bone Marrow Transplant in Chronic Insulin Dependent Diabetic Patients
Status: UNKNOWN
Conditions: Diabetes Mellitus Progression|Diabetes Complications
Interventions: BIOLOGICAL: Adult Bone Marrow Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Formulated Posterior Sub Tenon Triamcinolone in Macular Edema Secondary to Non-Ischemic Retinal Vein Occlusions
Status: COMPLETED
Conditions: Retinal Vein Occlusion
Interventions: DRUG: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous vs Intravenous Hydration on Older Adults
Status: COMPLETED
Conditions: Dehydration
Interventions: OTHER: Intravenous hydration|OTHER: Subcutaneous hydration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Permanent Pacemaker in Patients With Right Bundle Branch Block Undergoing Transcatheter Aortic Valve Implantation
Status: NOT_YET_RECRUITING
Conditions: Aortic Stenosis|Right Bundle-Branch Block
Interventions: DEVICE: Prophylactic pacemaker implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Behavioral and Enhanced Perinatal Intervention for Cessation (B-EPIC): Reducing Tobacco Use Among Opioid Addicted Women
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Behavioral and Enhanced Perinatal Intervention for Cessation (B-EPIC)|BEHAVIORAL: Treatment As Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Venous Thromboembolism Prophylaxis
Status: COMPLETED
Conditions: Venous Thromboembolism|Delivery of Health Care|Quality Improvement
Interventions: OTHER: VTE-P Tollgate|OTHER: BLAZE Pop up|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prevention of Preterm Delivery in Twin Pregnancies by 17 Alpha-hydroxyprogesterone Caproate
Status: COMPLETED
Conditions: Preterm Delivery
Interventions: DRUG: 17-alpha Hydroxyprogesterone Caproate|DRUG: Castor oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Biomarkers for Length of Hospital Stay and Loss of Muscle Mass and Function in Old Medical Patients
Status: COMPLETED
Conditions: Sarcopenia|Muscle Loss|Length of Stay
Interventions: OTHER: Development of a risk assessment tool based on clinical and functional measures and systemic biomarkers|OTHER: Development of a risk assessment tool for loss of muscle mass and physical function based on clinical and functional measures and systemic biomarkers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mi-iron - Moderately Increased Iron - is Reducing Iron Overload Necessary?
Status: COMPLETED
Conditions: Hereditary Haemochromatosis
Interventions: PROCEDURE: Erythrocytapheresis|PROCEDURE: Plasmapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Safety, Efficacy, and Immunogenicity of DR-5001
Status: COMPLETED
Conditions: Respiratory Tract Diseases
Interventions: BIOLOGICAL: DR-5001|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Prophylactic Cranial Irradiation Versus MRI Surveillance in Patients With Limited-stage Small Cell Lung Cancer Who Achieved Remission After First-line Chemoradiotherapy
Status: RECRUITING
Conditions: Limited Stage Small Cell Lung Cancer
Interventions: OTHER: MRI Surveillance|RADIATION: Prophylactic Cranial Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy (PDT) With Metvix Cream 160 mg/g Versus PDT With Placebo Cream in Participants With Primary Nodular Basal Cell Carcinoma
Status: COMPLETED
Conditions: Basal Cell Carcinoma
Interventions: RADIATION: Photodynamic Therapy (PDT)|DRUG: Metvix cream|DRUG: Placebo Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: CR845-100303: Study to Assess the Potential of Physical Withdrawal From Intravenous CR845 (Difelikefalin) in Hemodialysis Patients
Status: COMPLETED
Conditions: Hemodialysis
Interventions: DRUG: CR845 0.5 mcg/kg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Safety and Efficacy of Addition of Gentamicin on Irrigation Fluid in Prevention of Post-Transurethral Resection of the Prostate Infectious Complications.
Status: RECRUITING
Conditions: Post-TURP Infectious Complications
Interventions: PROCEDURE: Transurethral resection of the prostate (TURP)|DRUG: Gentamicin|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Localizing Epileptic Networks Using MRI and iEEG
Status: RECRUITING
Conditions: Epilepsy|Epilepsy Intractable|Epilepsy, Temporal Lobe
Interventions: DIAGNOSTIC_TEST: 3T Magnetic Resonance Imaging|DIAGNOSTIC_TEST: Intracranial electroencephalography recordings|DIAGNOSTIC_TEST: 7T Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cellular Therapy for In Utero Repair of Myelomeningocele - The CuRe Trial
Status: RECRUITING
Conditions: Myelomeningocele
Interventions: BIOLOGICAL: Placental Mesenchymal Stem Cells seeded on a commercially available dural graft extracellular matrix|OTHER: Untreated contemporaneous cohort
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intranasal Dexmedetomidine vs Oral Triclofos Sodium for EEG in Children With Autism
Status: UNKNOWN
Conditions: Autistic Disorder
Interventions: DRUG: Dexmedetomidine|DRUG: Triclofos 100 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib
Status: RECRUITING
Conditions: Endometrioid Cancer|Mucinous Ovarian Cancer|High Grade Serous Ovarian Cancer|Cervical Cancer|Solid Tumor
Interventions: DRUG: Avutometinib (VS-6766) + defactinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lumbar Assistive Exoskeletons in Caregiving
Status: RECRUITING
Conditions: Healthy|Low Back Pain|Musculoskeletal Pain|Musculoskeletal Injury
Interventions: DEVICE: Exoskeleton
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Hyperprolactinemia With the Non-ergoline Dopamine Agonist Ropinirole
Status: COMPLETED
Conditions: Hyperprolactinemia|Prolactinoma
Interventions: DRUG: Ropinirole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Guselkumab in the Treatment of Adults With Pyoderma Gangrenosum (PG)
Status: NOT_YET_RECRUITING
Conditions: Pyoderma Gangrenosum|Skin Diseases|Wound Heal|Pyoderma|Skin Ulcer
Interventions: DRUG: Guselkumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effects of a Neurobehavioral Intervention on Symptoms of Obsessive Compulsive Disorder
Status: COMPLETED
Conditions: Obsessive Compulsive Disorder
Interventions: BEHAVIORAL: Cognitive Control Training|BEHAVIORAL: Peripheral Vision Task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Hypoglycemia in Patients Without Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypoglycemia
Interventions: OTHER: Entry of demographic and medical history data into a deidentified database|GENETIC: Blood sample for DNA analysis|DIAGNOSTIC_TEST: Stool sample for microbiome analysis|DIAGNOSTIC_TEST: Mixed meal tolerance test|DIAGNOSTIC_TEST: Continuous glucose monitoring|DIAGNOSTIC_TEST: activity monitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enoxacin for Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Enoxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patients With Patent Foramen Ovale and Endocardial Device Leads on Apixaban for Prevention of Paradoxical Emboli
Status: WITHDRAWN
Conditions: Patent Foramen Ovale|Cardiac Implantable Electronic Device
Interventions: DRUG: Apixaban|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ph I Dose Escalation Trial of Vandetanib in Combo w Etoposide for Malignant Gliomas
Status: COMPLETED
Conditions: Gliosarcoma|Glioblastoma
Interventions: DRUG: Vandetanib and Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CHOP and Campath-1H in Previously Untreated Aggressive T/NK-Cell Lymphomas
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: CHOP|DRUG: Alemtuzumab|PROCEDURE: Plasma Samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Serratus Anterior Plan Block (SAP) and Pectoralis Blocks (PECS I-II) After Open Heart Surgery
Status: RECRUITING
Conditions: Postoperative Pain|Postoperative Complications|Side Effect
Interventions: PROCEDURE: Serratus anterior plane block|PROCEDURE: PECS I-II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: Web-based Tailored Information and Support for Patients With a Neuroendocrine Tumor: a Randomized Pilot Study
Status: COMPLETED
Conditions: Distress|Quality of Life|Neuroendocrine Tumor
Interventions: BEHAVIORAL: Web-based information and support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Concomitant Sensory Stimulation During Therapy to Enhance Hand Functional Recovery Post Stroke
Status: RECRUITING
Conditions: Stroke|Physical Disability
Interventions: DEVICE: real stimulation|DEVICE: No stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Antimicrobial Efficacy and Postoperative Pain After Using Silver Nanoparticles and Chitosan Nanoparticles Against Enterococcus Faecalis and Candida Albicans Biofilm
Status: COMPLETED
Conditions: Endodontic Disease
Interventions: DRUG: Silver Nanoparticles Irrigant|DRUG: Chitosan Nanoparticles Irrigant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel/Prednisone Plus Fractionated 177Lu- J591 Antibody for Metastatic, Castrate-resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Docetaxel|DRUG: Prednisone|DRUG: 177Lu-J591|DRUG: 177Lu-J591|DRUG: 177Lu-J591|DRUG: 177Lu-J591|DRUG: 177Lu-J591
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase 1 Trial of CD33xCD3 BsAb in Pediatric Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: TERMINATED
Conditions: AML, Childhood
Interventions: DRUG: CD33*CD3 BsAb
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecularly Targeted Theranostic Approach for the Detection and Treatment of Metastatic Carcinomas
Status: RECRUITING
Conditions: Metastatic Cancer
Interventions: DRUG: [68Ga]Ga DOTA-5G and [177Lu]Lu DOTA-ABM-5G.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus
Status: TERMINATED
Conditions: Chronic Kidney Diseases|Pruritus
Interventions: DRUG: Difelikefalin 1 mg Oral Tablet|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT