pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Single Lung Transplant (BOSTON-2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Bronchiolitis Obliterans|Chronic Rejection of Lung Transplant|Lung Transplant Rejection|Lung Transplant; Complications|Lung Transplant Failure and Rejection|Chronic Lung Allograft Dysfunction
Interventions: DRUG: Liposomal Cyclosporine A|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of High-fat and Low-fat Diet on the Gut
Status: COMPLETED
Conditions: Metabolic Syndrome X
Interventions: DIETARY_SUPPLEMENT: high fat diet followed by low fat diet|DIETARY_SUPPLEMENT: low fat diet followed by high fat diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Relative Bioavailability Study of Oxycodone 5 mg / Ibuprofen 400 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxycodone HCl 5 mg / Ibuprofen 400 mg tablets, single dose|DRUG: COMBONOX® tablets, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Trial Of Hypofractionated Radiotherapy In Combination With MEDI4736 And Tremelimumab For Patients With Metastatic Melanoma And Lung, Breast And Pancreatic Cancers
Status: COMPLETED
Conditions: Metastatic|Melanoma|Non Small Cell Lung Cancer (NSCLC)|Breast Cancer|Pancreatic Cancer
Interventions: RADIATION: Radiotherapy|DRUG: MEDI4736|DRUG: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes Associated With the Use of ViviGen® for the Treatment of Lumbar Degenerative Disc Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Lumbar Spondylolisthesis|Degenerative Disc Disease|Degenerative Spondylolisthesis|Lumbar Radiculopathy|Lumbar Spinal Stenosis|Lumbar Disc Disease
Interventions: COMBINATION_PRODUCT: ViviGen® Cellular Bone Matrix with DePuy Synthes Spinal Pedicle screw system|COMBINATION_PRODUCT: Local Bone Autologous Bone Graft with DePuy Synthes Spinal pedicle screw system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial Assessing the Effect of Pembrolizumab Combined With Radiotherapy in Patients With Relapsed, Refractory, Specified Stages of Cutaneous T-cell Lymphoma (CTCL) Mycosis Fungoides (MF)/Sezary Syndrome (SS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cutaneous T Cell Lymphoma|Mycosis Fungoides/Sezary Syndrome
Interventions: DRUG: Pembrolizumab|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Rifampicin on the PK of Multiple Doses of Balovaptin In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Balovaptan|DRUG: Rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Effect of a Contraceptive Vaginal Ring Delivering Ulipristal Acetate Combined With a Single or Repeated Levonorgestrel on Inhibition of Ovulation, Endometrial Changes and Bleeding Patterns in Normal Cycling Women
Status: UNKNOWN
Conditions: Ovulation Inhibition
Interventions: DRUG: Ulipristal acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Prevent the Complications of Insulin Resistance (Including Type-2 Diabetes)
Status: COMPLETED
Conditions: Insulin Resistance|Diabetes Mellitus
Interventions: DRUG: Metformin|PROCEDURE: skin biopsy|BEHAVIORAL: diet and exercise|DRUG: pioglitazone|DRUG: rosiglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of VX-659/TEZ/IVA in Cystic Fibrosis Subjects 6 Through 11 Years of Age
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DRUG: VX-659/TEZ/IVA|DRUG: IVA
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel and Diethylstilbestrol in the Treatment of Androgen Independent Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Docetaxel and Diethylstilbestrol (DES)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: McMaster Catheterization for Thoracoscopic Surgery Study
Status: WITHDRAWN
Conditions: Non-Small Cell Lung Cancer|Lung Neoplasms|Metastatic Lung Cancer|Urinary Retention|Urinary Tract Infections
Interventions: OTHER: No Foley Urinary Catheter|OTHER: Standard of care Foley urinary catheter insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: BATs Treatment for Pancreatic Cancer, Phase Ib/II
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Pancreatic Adenocarcinoma|Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: EGFR BATs after standard of care chemo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Morphine in Reducing the Rate of Early Non-Invasive Ventilation Failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Phase I/IIa
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Morphine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cisplatin and Gemcitabine Compared With Observation in Treating Patients Who Have Undergone Surgery for Bladder Cancer
Status: UNKNOWN
Conditions: Bladder Cancer
Interventions: DRUG: cisplatin|DRUG: gemcitabine hydrochloride|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparing of the Pharmacokinetic, Pharmacodynamic, Safety and Immunogenicity of MW032 and Xgeva® in Healthy Adults
Status: COMPLETED
Conditions: Bone Tumor
Interventions: DRUG: MW032|DRUG: Xgeva®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Effectiveness Study of DividPro Film in Open Abdominal Surgery
Status: RECRUITING
Conditions: Open Abdominal Surgery|Abdominal Adhesion
Interventions: DEVICE: DividPro film
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Puressentiel Purifying Spray on Asthma Control in Patients With Mild to Moderate Allergy-induced Asthma.
Status: UNKNOWN
Conditions: Asthma, Allergic
Interventions: OTHER: Biocide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Study of Single and Multiple Doses of Rabeprazole in Pediatric Patients With Gastroesophageal Reflux Disease (GERD) 1 to 11 Months Old, Inclusive
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease (GERD)
Interventions: DRUG: Rabeprazole sodium 5 mg|DRUG: Rabeprazole sodium 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effectiveness and Safety of JS1-1-01 in Patients With Moderate to Severe Depression
Status: RECRUITING
Conditions: Depression
Interventions: DRUG: Placebo group|DRUG: JS1-1-01 low-dose group|DRUG: JS1-1-01 pills; JS1-1-01 placebo pills; Duloxetine hydrochloride placebo capsules|DRUG: JS1-1-01 high-dose group|DRUG: Active drug group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Norketotifen in Adults With Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis|Allergic Rhinoconjunctivitis
Interventions: DRUG: Norketotifen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Symptomatic Treatment of Common Cold Symptoms
Status: COMPLETED
Conditions: Common Cold
Interventions: DRUG: Aspirin (Acetylsalicylic acid, BAYE4465)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LLLT and Fractional CO2 Laser in the Treatment of Stria Alba
Status: COMPLETED
Conditions: Striae; Albicantes
Interventions: DEVICE: Low level light therapy|DEVICE: Fractional CO2|DEVICE: Combined fractional CO2 laser and low level light therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dual REctcal Angiogenesis or MEK Inhibition radioTHERAPY Trial
Status: TERMINATED
Conditions: Rectal Cancer
Interventions: DRUG: AZD6244|DRUG: Cediranib (AZD2171)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Dietary Nitrate Effective in Reducing Aerobic Glycolysis in Breast Cancer?
Status: UNKNOWN
Conditions: Malignant Breast Tissue Neoplasm
Interventions: DIETARY_SUPPLEMENT: Beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Compare QUTENZA With Pregabalin for the Treatment of Peripheral Neuropathic Pain (PNP) After 8 Weeks of Treatment
Status: COMPLETED
Conditions: Non-diabetic Painful Peripheral Polyneuropathy|Postherpetic Neuralgia (PHN)|Peripheral Nerve Injury (PNI)
Interventions: DRUG: Qutenza|DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of Fluarix™ Vaccine in Children Who Have Previously Been Vaccinated With Pandemrix™
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluarix™|BIOLOGICAL: Havrix™ Junior
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Development of a Laboratory Test for the Detection of a Fluorescent-labeled Urease Inhibitor Marker Attached to Helicobacter Pylori
Status: UNKNOWN
Conditions: Helicobacter Pylori
Interventions: DIAGNOSTIC_TEST: Fluorescent-labeled Urease Inhibitor Marker to Detect Helicobacter Pylori
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Walking Rehabilitation After Spinal Cord Injury: Locomotor Training Using Adaptive Robotics
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Hybrid Assistive Limb (HAL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study of the Efficacy of Taxotere/Aptosyn Versus Taxotere/Placebo in Non-Small Cell Lung Cancer Patients
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Exisulind
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Ketamine Versus Placebo for Treatment Resistant Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Zoledronic Acid on Patients With Osteoarthritis of the Hip
Status: RECRUITING
Conditions: Osteoarthritis, Hip
Interventions: DRUG: Zoledronic Acid|DRUG: Saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dupilumab De-escalation in Pediatric Atopic Dermatitis
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: Dupilumab - Discontinuation|DRUG: Dupilumab - Dose Reduction|DRUG: Dupilumab - Standard Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: APG-1387 in Patients With Advanced Solid Tumors or Hematologic Malignancies
Status: COMPLETED
Conditions: Advanced Solid Tumors or Hematologic Malignancies
Interventions: DRUG: APG-1387 for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Toward Immune Biomarkers for Tolerance and GvHD in Humans
Status: UNKNOWN
Conditions: Bone Marrow Transplantation|Graft vs Host Disease|Hematopoietic Stem Cell Transplantation
Interventions: OTHER: Transplantation from an HLA-identical sibling donor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of IL4Rα Monoclonal Antibody in Patients With Seasonal Allergic Rhinitis(SAR).
Status: NOT_YET_RECRUITING
Conditions: Allergic Rhinitis
Interventions: BIOLOGICAL: GR1802 injection|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 68Ga-BNOTA-PRGD2 PET/CT in Patients With Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: 68Ga-BNOTA-PRGD2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate Efficacy and Safety of Inclisiran in Adolescents With Heterozygous Familial Hypercholesterolemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Familial Hypercholesterolemia - Heterozygous
Interventions: DRUG: Inclisiran|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Skin Health and Effectiveness of Standardized Skin Care Regimens in Nursing Home Residents
Status: COMPLETED
Conditions: Xerosis Cutis
Interventions: OTHER: Cetaphil® Restoraderm|OTHER: Excipial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stress and Rest Myocardial Tomoscintigraphies Using Mono- or Double-isotope Protocol With a Semiconductor Camera
Status: COMPLETED
Conditions: Myocardial Perfusion
Interventions: PROCEDURE: Tomoscintigraphy with D.SPECT camera (SPECTRUM Dynamics®, Israel)|DRUG: 99mTc-Sestamibi|DRUG: Thallium-201
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Irinotecan And Bevacizumab Combined With Re-radiotherapy in Recurrent Glioblastoma
Status: RECRUITING
Conditions: Recurrent Glioblastoma
Interventions: DRUG: Bevacizumab，Irinotecan and Re-radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Case Crossover Study of Intermittent Fasting in CLL/SLL
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia (CLL)|Small Lymphocytic Lymphoma (SLL)
Interventions: BEHAVIORAL: 5:2 Method (intermittent fasting regimen)|BEHAVIORAL: 16/8 Method (intermittent fast regimen)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intracavitary Photodynamic Therapy as an Adjuvant to Resection of Glioblastoma or Gliosarcoma Using IV Photobac®
Status: RECRUITING
Conditions: Glioblastoma Multiforme of Brain|Glioma, Sarcomatous
Interventions: COMBINATION_PRODUCT: photochemotherapy using 3-(1-Butyloxy)ethyl-3-deacetyl-bacteriopurpurin-18-n-butylimide methyl ester(Photobac®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Collaborative Problem Solving vs. Positive Solutions for Families in Preschool Parent Groups
Status: TERMINATED
Conditions: Child Behavior|Problem Behavior|Family Conflict
Interventions: BEHAVIORAL: Collaborative Problem Solving|BEHAVIORAL: Positive Solutions For Families
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Pembrolizumab in Patients With Malignant Peripheral Nerve Sheath Tumor (MPNST), Not Eligible for Curative Surgery
Status: TERMINATED
Conditions: Malignant Peripheral Nerve Sheath Tumour (MPNST)
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Oral Hygiene & Root Resorption During Orthodontic Treatment
Status: COMPLETED
Conditions: Orthodontic Pathological Resorption of External Root|Complication of Personal Oral Hygiene
Interventions: DEVICE: Appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Temsirolimus/AZD 6244 for Treatment-naive With BRAF Mutant Unresectable Stage IV
Status: TERMINATED
Conditions: Mucosal Melanoma|Recurrent Melanoma|Stage IV Melanoma
Interventions: DRUG: temsirolimus|DRUG: selumetinib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing mHealth to Promote PrEP Use Among Thai Young Vulnerable Adolescents and Emerging Adults
Status: RECRUITING
Conditions: Pre-Exposure Prophylaxis
Interventions: BEHAVIORAL: Behavioral: Motivational Enhancement System for PrEP Uptake and Adherence (MES-PrEP)|BEHAVIORAL: Enhanced YaCool|BEHAVIORAL: Standard PrEP Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Latanoprost Plus NB-UVB Versus Each Alone in Non-segmental Vitiligo: Clinical and Laboratory Evaluation
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-segmental Vitiligo
Interventions: RADIATION: NB-UVB|DRUG: Latanoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magtrial: Magtrace® as Tracer for Sentinel Lymph Node Detection in Early Stage Epithelial Ovarian Cancer
Status: NOT_YET_RECRUITING
Conditions: Ovarian Cancer|Lymph Node Metastasis
Interventions: DEVICE: Magtrace
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E)
Status: TERMINATED
Conditions: Huntington's Disease
Interventions: DRUG: Creatine Monohydrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cisplatin + Etoposide +/- Concurrent ZD6474 in Previously Untreated Extensive Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Cisplatin|DRUG: Etoposide|DRUG: Placebo|DRUG: ZD6474
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate LY3154207 on the Brain of Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3154207|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Counterfactual Strategies, Physical Activity, and Wearable Trackers
Status: COMPLETED
Conditions: Financial Stress|Socioeconomic Status|Social Status
Interventions: BEHAVIORAL: Counterfactual Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety, Tolerability, and Immunogenicity of GTL001 Vaccine Adjuvanted With Imiquimod Cream in HPV 16- and/or HPV 18-Infected Women Aged 25 to 65 Years, With Normal Cytology, ASCUS, or LSIL
Status: TERMINATED
Conditions: HPV 16- and/or HPV 18-Infected Women With Normal Cytology, ASCUS, or LSIL
Interventions: DRUG: GTL001+|DRUG: Aldara
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Ability of a Novel Endocrine Treatment for Breast Cancer, Irosustat, to Slow Down Cancer Growth
Status: TERMINATED
Conditions: Breast Neoplasms
Interventions: DRUG: Irosustat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Cladribine Add-on to Interferon-beta (IFN-beta) Therapy in Multiple Sclerosis (MS) Subjects With Active Disease (ONWARD)
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Cladribine|DRUG: Placebo|DRUG: Interferon-beta (IFN-beta)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single, Ascending Dose, First Time in Human Study for GZR18 in Healthy Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: GZR-18|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pectointercostal Fascial Plane Block Chronic Pain Sternotomy
Status: RECRUITING
Conditions: Chronic Pain
Interventions: OTHER: local anesthetic injection|OTHER: Standard perioperative and postoperative analgesia protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of ProgenaMatrix™ in the Management of DFUs
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: ProgenaMatrix Keratin graft|OTHER: standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Suberoylanilide Hydroxamic Acid in Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DRUG: vorinostat (Suberoylanilide Hydroxamic Acid [SAHA]) in combination with Pemetrexed and Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RRI Compared With NephroCheckTM to Predict Acute Renal Failure After Cardiac Surgery.
Status: COMPLETED
Conditions: Cardiac Surgery|Extracorporeal Circulation|Nephrocheck|Renal Failure
Interventions: PROCEDURE: Renal Resistive Index compared with NephroCheckTM
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Using Fascia Lata Membrane Versus Connective Tissue Graft in Immediate Implants
Status: UNKNOWN
Conditions: Connective Tissue Graft|Anterior Aesthetic Zone
Interventions: PROCEDURE: Test|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Of Deep Versus Moderate Neuromuscular Blockade on Intra-Operative Blood Loss During Spinal Surgery
Status: UNKNOWN
Conditions: Spine Fracture
Interventions: DRUG: Rocuronium|DEVICE: nerve stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effectiveness of Preemptive Nebulized Dexamethasone in Reducing Post-Operative Sore Throat in Supraglottic Airway
Status: COMPLETED
Conditions: Sore Throat|Hoarseness|Dexamethasone|Supraglottic Airway Devices
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacodynamics of Omiganan BID in Patients With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Omiganan|DRUG: Omiganan|DRUG: Omiganan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Naltrexone-Induced Blockade of Antidepressant Effects
Status: COMPLETED
Conditions: Depression|Major Depressive Disorder
Interventions: DRUG: Naltrexone 50 Mg Oral Tablet|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intraoperative Dobutamine Stress Test With Speckle Tracking to Decrease Postoperative Mortality (ISTMO)
Status: UNKNOWN
Conditions: Mortality After Major Non Cardiac Surgery
Interventions: DIAGNOSTIC_TEST: Dobutamine stress test with trans-esophageal echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Nutritional Deficiencies Preventive Treatment Prior to Laparoscopic Sleeve Gastrectomy
Status: COMPLETED
Conditions: Disorder of Bone Density and Structure, Unspecified|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Multi vitamin|DIETARY_SUPPLEMENT: vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: INC280 Combined With Bevacizumab in Patients With Glioblastoma Multiforme
Status: COMPLETED
Conditions: Glioblastoma Multiforme|Gliosarcoma|Colorectal Cancer|Renal Cell Carcinoma
Interventions: DRUG: INC280|BIOLOGICAL: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Early Intervention in Hearing Impaired Children Using Functional Near-Infrared Spectroscopy (fNIRS)
Status: RECRUITING
Conditions: Hearing Impairment
Interventions: OTHER: Provision of standard audiological + fNIRS test results|OTHER: Provision of standard audiological test results only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Food Effect and Relative Bioavailability Study of Rilzabrutinib in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: rilzabrutinib SAR444671|DRUG: rilzabrutinib SAR444671|DRUG: rilzabrutinib SAR444671
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Masking on Subjective Results During Daily Disposable Contact Lens Studies
Status: COMPLETED
Conditions: Myopia|Hyperopia
Interventions: DEVICE: Nelfilcon A contact lens|DEVICE: Nelfilcon A contact lens with comfort additive (DACP), unmasked|DEVICE: Nelfilcon A contact lens with comfort additive (DACP), masked|DEVICE: Nelfilcon A contact lens with comfort additive (DACP), partially masked|DEVICE: Etafilcon A contact lens|DEVICE: Etafilcon A contact lens with comfort additive (1DAVM), unmasked|DEVICE: Etafilcon A contact lens with comfort additive (1DAVM), masked|DEVICE: Etafilcon A contact lens with comfort additive (1DAVM), partially masked
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neural Glide Technique on the Sciatic Nerve and the Passive Stretching Technique in the Short Hamstring Muscles
Status: COMPLETED
Conditions: Hamstring Muscles|Sciatic Nerve|Flexibility
Interventions: OTHER: Stretching of the hamstring muscles.|OTHER: Neural slippage of the sciatic nerve.|OTHER: Passive upper limb mobilisations.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics and Antitumor Activity of BGB-B167 Alone and in Combination With Tislelizumab in Participants With Solid Tumors in Chinese Participants
Status: WITHDRAWN
Conditions: Solid Tumors
Interventions: DRUG: BGB-B167|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Optimization of Cardiac Resynchronization Therapy (CRT)Using Echocardiography and SonR
Status: COMPLETED
Conditions: Heart Failure
Interventions: DEVICE: Control|DEVICE: Experimental|DEVICE: Experimental 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pembrolizumab/Placebo Plus Trastuzumab Plus Chemotherapy in Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Advanced Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-811/KEYNOTE-811)
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Neoplasms|Gastroesophageal Junction Adenocarcinoma
Interventions: BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Placebo|DRUG: Cisplatin|DRUG: 5-FU|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: S-1|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mulberry Leaf Extract Capsule on Blood Glucose Control in Healthy Volunteers
Status: NOT_YET_RECRUITING
Conditions: Health, Subjective
Interventions: DRUG: Mulberry leaf extract 6 mg capsule|DRUG: Mulberry leaf extract 12 mg capsule|DRUG: Mulberry leaf extract 18 mg capsule|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: KP-10 and Insulin Secretion in Men
Status: COMPLETED
Conditions: Kisspeptin Action on Insulin in Healthy Normal Men|Kisspeptin Action on Insulin in Obese Diabetic Men
Interventions: BIOLOGICAL: Kisspeptin-10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Metacognitive ADHD Telehealth Intervention for Work-performance Enhancement (Work-MATE)
Status: COMPLETED
Conditions: ADHD
Interventions: BEHAVIORAL: The Metacognitive ADHD Telehealth intervention for Work-performance Enhancement (Work-MATE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Bortezomib With Chemotherapy for Relapsed Pediatric Acute Lymphoblastic Leukemia (ALL)
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Bortezomib|DRUG: Dexamethasone|DRUG: PEG-asparaginase|DRUG: Doxorubicin|DRUG: Cytarabine|DRUG: Methotrexate|DRUG: Vincristine|DRUG: Triple IT Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Maca Root for the Treatment of Antidepressant-Induced Sexual Dysfunction in Females
Status: COMPLETED
Conditions: Antidepressant Induced Sexual Dysfunction
Interventions: DRUG: Maca Root|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Chemotherapy in Patients With Lymph Node Metastasis After Radical Surgery in Cervical Cancer
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: DRUG: paclitaxel|DRUG: Cisplatin 50mg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Effects of Variations in Net Ultrafiltration Rate During Continuous Renal Replacement Therapy.
Status: RECRUITING
Conditions: Fluid Overload|Hemodynamic Instability
Interventions: DEVICE: Net Ultra Filtration Rate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ROBUST I Pilot Study, Re-Establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease
Status: COMPLETED
Conditions: Stricture Urethra
Interventions: COMBINATION_PRODUCT: Urotronic Drug Coated Balloon (DCB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Result of tDCS in ASD Children With Comorbidities Like PANDAS, Rare Genetic Diseases or Autoimmune Disorders
Status: ENROLLING_BY_INVITATION
Conditions: Attention|Visual Perceptual Weakness|Social Behavior|Fluency Disorder|EEG With Periodic Abnormalities
Interventions: DEVICE: tDCS or Transcranial Direct Current Stimulation|DRUG: Risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Anti-vascular Endothelial Growth Factor Administration and Its Influence on Vitreomacular Interface- and Retinal Morphology in Eyes With Neovascular Age-related Macular Degeneration
Status: COMPLETED
Conditions: Vitreomacular Interface
Interventions: DEVICE: OCT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Melatonin and Cardiac Outcome After Major Surgery
Status: COMPLETED
Conditions: Aortic Aneurysm
Interventions: DRUG: Melatonin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Amyloid Prediction in Early Stage Alzheimer's Disease From Acoustic and Linguistic Patterns of Speech - FUTURE Extension
Status: TERMINATED
Conditions: Alzheimer Disease|Preclinical Alzheimer's Disease|Prodromal Alzheimer's Disease|Alzheimer's Disease (Incl Subtypes)|Mild Cognitive Impairment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Safety and Efficacy of Spherical Microwave Ablation for the Treatment of Malignant Liver Tumors
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma (HCC)
Interventions: PROCEDURE: The Solero Microwave Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EBV Specific Cytokine Secreting TCR-T Cells in the Treatment of EBV-Positive Metastatic/Refractory Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: EBV-specific TCR-T cell with cytokine auto-secreting element
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of KZR-616 to Evaluate Safety and Efficacy in Patients With Active Polymyositis or Dermatomyositis
Status: COMPLETED
Conditions: Polymyositis|Dermatomyositis
Interventions: DRUG: KZR-616|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Pharmacodynamic and Pharmacokinetic Study of DG3173
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DG3173|DRUG: Saline|DRUG: Octreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of 1 Month Daily (1HP) and 3 Months Weekly (3HP) Isoniazid and Rifapentine With Pharmacokinetics of Dolutegravir (DTG) in Pregnant People With HIV
Status: RECRUITING
Conditions: HIV Seropositivity|Pregnancy|Tuberculosis Infection
Interventions: DRUG: Rifapentine|DRUG: Isoniazid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Hearing-aid Treatment for Patients With Tinnitus and Co-existing Hearing Loss
Status: UNKNOWN
Conditions: Tinnitus, Subjective|Hearing Loss, High-Frequency
Interventions: DEVICE: Hearing aids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sensitivity of Pharmacokinetics to Differences in Particle Size Distribution of Suspension-based Nasal Sprays
Status: COMPLETED
Conditions: Hypersensitivity
Interventions: DRUG: Mometasone furoate drug formulation (MFF) 1|DRUG: Mometasone furoate drug formulation (MFF) 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: A Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Participants With Resected Pancreatic Ductal Adenocarcinoma
Status: RECRUITING
Conditions: Adenocarcinoma, Pancreatic Ductal
Interventions: DRUG: Autogene cevumeran|DRUG: Atezolizumab|DRUG: mFOLFIRINOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TracelT Hydrogel in Localizing Bladder Tumors in Patients Undergoing Radiation Therapy for Bladder Cancer
Status: COMPLETED
Conditions: Bladder Carcinoma
Interventions: DEVICE: Polyethylene Glycol Hydrogel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety Study of Azacitidine in Cancer Patients With and Without Impaired Renal Function
Status: COMPLETED
Conditions: MDS|AML|Solid Tumors|Multiple Myeloma|Non-Hodgkin's Lymphoma|Hodgkin's Disease
Interventions: DRUG: azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Multimodal Intervention for Cachexia in Advanced Cancer Patients Undergoing Chemotherapy
Status: COMPLETED
Conditions: Cachexia|Neoplasms
Interventions: OTHER: standard care|OTHER: nutritional supplements and advice|OTHER: home-based self-assisted exercise program|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Dose-escalation Vaccine Trial in HER2-overexpressing Patients With High-risk Breast Cancer
Status: COMPLETED
Conditions: Neoplasms, Breast
Interventions: BIOLOGICAL: Immunotherapeutic SB719125 (Primary)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of 0.1% Pilocarpine Mouthwash on Xerostomia
Status: COMPLETED
Conditions: Xerostomia
Interventions: DRUG: Pilocarpine|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combined Illness Management and Psychotherapy in Treating Depressed Elders
Status: COMPLETED
Conditions: Depression|Heart Failure|Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: Combined Psychotherapy and Illness Management|BEHAVIORAL: Illness Management Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The First-line Treatment of RCLM With RAS Mutation Was Local Short-course Radiotherapy (SCRT) + PD-1+ Standard Therapy
Status: NOT_YET_RECRUITING
Conditions: Rectal Cancer
Interventions: DRUG: PD-1|RADIATION: SCRT|DRUG: Bevacizumab|DRUG: Oxaliplatin|DRUG: Calcium folinate|DRUG: 5-fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STELLA 2 Trial: Transperitoneal vs. Extraperitoneal Approach for Laparoscopic Staging of Endometrial/Ovarian Cancer
Status: COMPLETED
Conditions: Endometrial Neoplasms|Ovarian Neoplasms
Interventions: PROCEDURE: Extraperitoneal Laparoscopic aortic lymphadenectomy|PROCEDURE: Transperitoneal Laparoscopic aortic lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: I2S-Health Prevention
Status: UNKNOWN
Conditions: Secondary School Student in General High School Who Does Not Have a Disability That Does Not Allow a Good Understanding of the Study Requirements
Interventions: BEHAVIORAL: Impulsive intervention|BEHAVIORAL: Reflective Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Freshly Manufactured 35kDa Hyaluronan Fragment HA35 for the Treatment of Chronic Wounds
Status: COMPLETED
Conditions: Chronic Wounds
Interventions: DRUG: HA35(L20200708MP07707, Ministry of Health, Mongolia)was freshly manufactured by mixing hyaluronidase PH20 injectable solution (H31022111) and high-molecular-weight HA injectable solution (H20174089)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CREATE: Cross-tumoral Phase 2 With Crizotinib
Status: COMPLETED
Conditions: Locally Advanced and/or Metastatic Anaplastic Large Cell Lymphoma|Locally Advanced and/or Metastatic Inflammatory Myofibroblastic Tumor|Locally Advanced and/or Metastatic Papillary Renal Cell Carcinoma Type 1|Locally Advanced and/or Metastatic Alveolar Soft Part Sarcoma|Locally Advanced and/or Metastatic Clear Cell Sarcoma|Locally Advanced and/or Metastatic Alveolar Rhabdomyosarcoma
Interventions: DRUG: Crizotinib (PF-02341066)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Immunogenicity, and Dose Ranging Study of Inactivated Zika Virus Vaccine in Healthy Participants
Status: COMPLETED
Conditions: Virus, Zika|Zika Virus Disease|Flavivirus Infections|Healthy Participants
Interventions: DRUG: Placebo|BIOLOGICAL: PIZV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Electrical Stimulation for the Treatment of Optic Neuropathies
Status: RECRUITING
Conditions: Glaucoma|Glaucoma, Open-Angle|Optic Nerve Diseases
Interventions: DEVICE: Repetitive, Transorbital Alternating Current Stimulation (rtACS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Post-Traumatic Stress Disorder Treatment by Reconsolidation Therapy on Fibromyalgia Syndrome
Status: RECRUITING
Conditions: Fibromyalgia Syndrome|Posttraumatic Stress Disorder
Interventions: DRUG: Propranolol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ROGYcare: The Impact of a Cancer Survivorship Care Plan on Patient Reported Outcomes and Health Care Providers
Status: COMPLETED
Conditions: Ovarian Cancer|Endometrium Cancer
Interventions: OTHER: SCP care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acute Study on Muscle Soreness, Damage, and Performance
Status: COMPLETED
Conditions: Soreness, Muscle|Performance Enhancing Product Use|Damage Muscle
Interventions: DIETARY_SUPPLEMENT: Pre-workout plus and protein recovery plus|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of Nalbuphine (Extended Release) ER in Idiopathic Pulmonary Fibrosis (IPF) for Treatment of Cough
Status: COMPLETED
Conditions: Nalbuphine|Idiopathic Pulmonary Fibrosis|Cough
Interventions: DRUG: NAL ER|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Virtual Reality (VR) in Non-oncologic Chronic Musculoskeletal Pain
Status: ENROLLING_BY_INVITATION
Conditions: Musculoskeletal Pain|Fibromyalgia, Primary
Interventions: DEVICE: software
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Does Vitamin D Improves Sustained Virologic Response (SVR) in Genotype 2,3 Chronic Hepatitis C Patients?
Status: UNKNOWN
Conditions: Hepatitis C
Interventions: DRUG: Peg+ Vitamin D+ Ribavirine|DRUG: Peg+ Ribavirine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Growth and Tolerance of Healthy Term Infants Fed Cow's Milk-Based Infant Formulas
Status: WITHDRAWN
Conditions: Growth
Interventions: OTHER: Marketed cow's milk-based infant formula|OTHER: Cow's milk-based infant formula with added nutrients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER