pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: huCART-meso + VCN-01 in Pancreatic and Ovarian Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer|Serous Ovarian Cancer
Interventions: BIOLOGICAL: VCN-01|BIOLOGICAL: huCART-meso Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LINNOVATE: Lurbinectedin, Ipilimumab and Nivolumab for Soft Tissue Sarcoma
Status: RECRUITING
Conditions: Advanced Soft-tissue Sarcoma
Interventions: DRUG: Lurbinectedin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxytocin on Approach Bias and Craving
Status: WITHDRAWN
Conditions: Alcohol Use Disorder
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Anakinra in Combination With Riluzol in Amyotrophic Lateral Sclerosis
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis (ALS)
Interventions: DRUG: Anakinra
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CGT9486 (Formerly Known as PLX9486) as a Single Agent and in Combination With PLX3397 (Pexidartinib) or Sunitinib in Participants With Advanced Solid Tumors
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumors
Interventions: DRUG: PLX9486|DRUG: Pexidartinib|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calcium Aluminosilicate Anti-Diarrheal in Treating and Preventing Diarrhea in Patients With Metastatic Colorectal Cancer Receiving Irinotecan
Status: COMPLETED
Conditions: Chemotherapeutic Agent Toxicity|Colorectal Cancer|Diarrhea
Interventions: DRUG: calcium aluminosilicate anti-diarrheal|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Preoperative Education on Postoperative Healing Quality in Patients With Mastectomy
Status: UNKNOWN
Conditions: Mastectomy; Lymphedema|Breast Cancer
Interventions: OTHER: Supportive care and education before surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Transfusion-requirements in Septic Shock Trial
Status: COMPLETED
Conditions: Septic Shock
Interventions: BIOLOGICAL: SAGM (Saline-Adenine-Glucose-Mannitol) blood transfusion|BIOLOGICAL: SAGM (Saline-Adenine-Glucose-Mannitol) blood transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Heat Emergency Awareness and Treatment (HEAT)
Status: COMPLETED
Conditions: Heat Illness|Heat Stroke|Heat Exhaustion|Heat Exposure|Heat Syncope, Sequela|Heat Collapse|Heat|Heat Stroke and Sunstroke
Interventions: BEHAVIORAL: Implementation of Community-based Home Heat Bundle|BEHAVIORAL: Regular Community Healthcare provision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Brief Guided Relaxation for Women Undergoing Stereotactic Breast Biopsy
Status: COMPLETED
Conditions: Meditation for Breast Biopsy
Interventions: PROCEDURE: Meditation|PROCEDURE: Electroencephalogram|BEHAVIORAL: Questionnaires|PROCEDURE: Heart Rate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Three Different Devices for Kidney Stone Removal During Percutaneous Surgery
Status: COMPLETED
Conditions: Kidney Stones
Interventions: DEVICE: Cyberwand|DEVICE: Stonebreaker|DEVICE: Lithoclast Select
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Functional Studies of Novel Genes Mutated in Primary Ciliary Dyskinesia II: Genotype to Phenotype
Status: RECRUITING
Conditions: Primary Ciliary Dyskinesia
Interventions: DRUG: Albuterol|DIAGNOSTIC_TEST: Technetium99m - Sulfur Colloid (Tc99m-SC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Global Safety and Efficacy Registration Study of Crinecerfont for Congenital Adrenal Hyperplasia
Status: ACTIVE_NOT_RECRUITING
Conditions: Congenital Adrenal Hyperplasia
Interventions: DRUG: Crinecerfont|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PREVAIL-20J - Transfemoral Placement of 20mm Aortic Balloon Expandable Transcatheter Valve Trial
Status: COMPLETED
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: SAPIEN XT NovaFlex delivery system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calcium + Vitamin D Supplementation for Low Bone Mass in Adolescent Idiopathic Scoliosis (AIS)
Status: COMPLETED
Conditions: Scoliosis
Interventions: DIETARY_SUPPLEMENT: Calcium 600mg plus Vit D 400 IU|DIETARY_SUPPLEMENT: Calcium 600mg plus Vit D 800 IU|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Herbal Mouth Rinse for Chronic Periodontitis
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: OTHER: Placebo mouth rinse|DRUG: Chlorhexidine mouth rinse|DRUG: Test group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effect of Different Treatment Course With Inhaled Corticosteroids in Eosinophilic Bronchitis Patients
Status: COMPLETED
Conditions: Eosinophilic Bronchitis
Interventions: DRUG: Inhaled budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stem Cells in Rapidly Evolving Active Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Mesenchymal stem cells|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Investigate The Safety And Possible Clinical Benefit Of Multistem(r) In Patients With Moderate To Severe Ulcerative Colitis
Status: COMPLETED
Conditions: Colitis, Ulcerative
Interventions: DRUG: placebo|DRUG: MultiStem low dose|DRUG: placebo|DRUG: MultiStem low dose|DRUG: placebo|DRUG: MultiStem high dose|DRUG: placebo|DRUG: MultiStem high dose|DRUG: placebo|DRUG: MultiStem high dose|DRUG: placebo|DRUG: MultiStem high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TT-10 as a Single Agent in Subjects With Advanced Selected Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Cancer|Castrate Resistant Prostate Cancer|Non Small Cell Lung Cancer|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: TT-10
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of an Allied Health Team in the Emergency Department on Older Adults' Care
Status: UNKNOWN
Conditions: ED-based Allied Health Services
Interventions: OTHER: HSCP intervention|OTHER: ED routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intraoperative Parathyroid Hormone Monitoring to Guide Surgery in Renal hyperparathyroIdism
Status: NOT_YET_RECRUITING
Conditions: Secondary Hyperparathyroidism|Tertiary Hyperparathyroidism
Interventions: PROCEDURE: Intraoperative parathyroid hormone (IOPTH) monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Supportive Care Intervention for Older Caregivers of Older Adults With Advanced Cancer
Status: TERMINATED
Conditions: Cancer
Interventions: OTHER: Experimental (Delphi Surveys)|OTHER: Experimental (Focus Groups)|OTHER: Qualitative interviews
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy in Treating Patients With Advanced Solid Tumors
Status: WITHDRAWN
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: etoposide|DRUG: leucovorin calcium|DRUG: tegafur-uracil
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effectiveness Comparison Between the Drugs TOBRACORT® and TOBRADEX® in Reducing the Signs and Symptoms of Acute Bacterial Conjunctivitis
Status: UNKNOWN
Conditions: Acute Bacterial Conjunctivitis
Interventions: DRUG: Tobracort|DRUG: Tobradex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Antifungal Treatment for Tinea Cruris
Status: COMPLETED
Conditions: Tinea Cruris
Interventions: DRUG: 33525|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Xiidra on Closed Eye Tear Film Leukocytes in Dry Eye Disease
Status: WITHDRAWN
Conditions: Ocular Discomfort|Ocular Inflammation|Dry Eye|Contact Lens Complication|Keratoconjunctivitis Sicca
Interventions: DRUG: Lifitegrast
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of NAFT-600 in Subjects With Tinea Pedis
Status: COMPLETED
Conditions: Tinea Pedis
Interventions: DRUG: NAFT-600 ( naftin 2 % gel )|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improvement of Tinnitus After Oral Zinc on Patients With Noise-induced Hearing Loss
Status: COMPLETED
Conditions: Hearing Loss, Noise-Induced|Tinnitus, Noise Induced|Zinc Deficiency
Interventions: DRUG: zinc gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Radiation Therapy Plus Bone Marrow Transplantation in Treating Patients With Aggressive Non-Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: BIOLOGICAL: bleomycin sulfate|DRUG: carmustine|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: melphalan|DRUG: prednisolone|DRUG: vincristine sulfate|PROCEDURE: autologous bone marrow transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: An Evaluation of a Physiology-guided PCI Optimisation Strategy
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Stenosis
Interventions: PROCEDURE: P.I.O.S.|DIAGNOSTIC_TEST: Pre and post-PCI coronary physiology measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Prehospital Kcentra for Hemorrhagic Shock
Status: ACTIVE_NOT_RECRUITING
Conditions: Trauma Injury
Interventions: DRUG: Prothrombin Complex Concentrate, Human|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Multicenter Trial to Explore the Tolerability and Safety of the H-Coil Deep TMS in Combination With Serotonin Selective Reuptake Inhibitor(SSRI)
Status: COMPLETED
Conditions: Major Depressive Disorder, Recurrent, Unspecified|Major Depressive Disorder, Single Episode, Unspecified
Interventions: DEVICE: H-Coil Deep TMS in combination with SSRIs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of the Combined Modality Therapy in Adenocarcinoma of the Esophago-gastric Junction
Status: UNKNOWN
Conditions: Adenocarcinoma of the Gastroesophageal Junction
Interventions: OTHER: preoperative chemo- and chemoradiotherapy|PROCEDURE: Surgical resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Scalp Cooling to Prevent Hair Loss in Patients Undergoing Stem Cell Transplantation for Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DEVICE: Penguin Cold Cap
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Study of Envafolimab Combined With Concurrent Chemoradiotherapy In LS-SCLC
Status: NOT_YET_RECRUITING
Conditions: Lung Neoplasms
Interventions: DRUG: Envafolimab combined with concurrent chemoradiotherapy (Hypofractionated radiotherapy)|DRUG: Envafolimab combined with concurrent chemoradiotherapy (Conventional Radiotherapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation
Status: ENROLLING_BY_INVITATION
Conditions: Aortic Valve Stenosis|Heart Valve Diseases|Aortic Valve Disease|Heart Disease Structural Disorder
Interventions: DEVICE: Navitor Transcatheter Aortic Valve Implantation (TAVI) System|DEVICE: Any Commercially Available Transcatheter Aortic Valve (CAV) System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Jing Si Herbal Tea in the Treatment of Dyspeptic Symptoms
Status: COMPLETED
Conditions: Functional Gastrointestinal Disorders|Healthy Subjects
Interventions: DIETARY_SUPPLEMENT: Jing Si Herbal Tea Liquid Packet|DIETARY_SUPPLEMENT: Jing Si Herbal Tea Liquid Packet Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety of the Respiratory Syncytial Virus Vaccine MEDI7510 in Older Adults
Status: COMPLETED
Conditions: Respiratory Syncytial Virus (RSV)
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: RSV sF 20 mcg|BIOLOGICAL: MEDI7510 (20 mcg RSV sF)|BIOLOGICAL: RSV sF 50 mcg|BIOLOGICAL: MEDI7510 (50 mcg RSV sF)|BIOLOGICAL: RSV sF 80 mcg|BIOLOGICAL: MEDI7510 (80 mcg RSV sF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI)
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DRUG: Chondroitin sulphate (Condrosan®)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of High Density Sit-to-stand Functional Resistance Training in Patients With Hip Fracture
Status: RECRUITING
Conditions: Hip Fractures|Sarcopenia|Fall Injury
Interventions: DIETARY_SUPPLEMENT: Basic intervention and nutritional intervention|PROCEDURE: Sit-to-stand|PROCEDURE: Leg press|PROCEDURE: Hip abduction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gluteal Activation With or Without Traction Straight Leg Raise Technique
Status: COMPLETED
Conditions: SIJ - Sprain of Sacroiliac Joint|Weakness, Muscle|Tightness of Back Muscles
Interventions: OTHER: Traction straight leg raise technique for hamstring|OTHER: Gluteal activation exercises,Hotpack
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Blood-Brain Barrier Disruption (BBBD) in Subjects With Suspected Infiltrating Glioma
Status: SUSPENDED
Conditions: Glioma
Interventions: DEVICE: Exablate BBBD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS)
Status: UNKNOWN
Conditions: Acute Respiratory Distress Syndrome
Interventions: DRUG: NIMBEX|DRUG: NIMBEX|OTHER: WITHOUT NIMBEX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exposure to Plasticisers in the Neonatal Intensive Care Unit
Status: COMPLETED
Conditions: Preterm Birth|Premature Birth|Neurodevelopmental Disorders|Pulmonary Disease|Bronchopulmonary Dysplasia|Harm Reduction|Environmental Exposure|Development, Infant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) in Patients With Hyperlipidemia and Statin Intolerant
Status: COMPLETED
Conditions: Hypercholesterolemia|Atherosclerotic Cardiovascular Disease|Statin Adverse Reaction
Interventions: DRUG: bempedoic acid|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Counteracting Deleterious Metabolic Glucocorticoid Effects With Metformin
Status: COMPLETED
Conditions: Glucocorticoid Effect
Interventions: DRUG: Metformin 500 mg Oral Tablets + Prednisone 20mg Tablets|DRUG: Placebo 500 mg Tablets + Prednisone 20mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 1, Multicenter, Open-Label Study to Evaluate the Effect of Mild or Moderate Hepatic Impairment on the Multiple-Dose Pharmacokinetics of Ozanimod
Status: COMPLETED
Conditions: Liver Diseases|Digestive System Diseases
Interventions: DRUG: Ozanimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intrauterine Saline Washing for Detection Endometrial Disease in Patients With Abnormal Uterine Bleeding
Status: UNKNOWN
Conditions: Endometrial Disease
Interventions: PROCEDURE: Endometrial saline plus curettage|PROCEDURE: Endometrial curettage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Phicogenic vs. Xenogeneic Biomaterial for Maxillary Sinus Floor Elevation
Status: COMPLETED
Conditions: Sinus Floor Augmentation
Interventions: DEVICE: Biphasic phycogenic biomaterial|DEVICE: Xenograft bovine hydroxyapatite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: In Vitro Evaluation of Spontaneous and Oxytocin-induced Contractility of Pregnant Human Myometrium During Exposure to Dexmedetomidine
Status: RECRUITING
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Oxytocin|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Effect of Dosing AZD6244 HydSulfate in the Presence and Absence of Food in Patients With Advanced Solid Malignancies
Status: COMPLETED
Conditions: Melanoma|Malignant Melanoma
Interventions: DRUG: AZD6244
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Trans Cranial Direct Current Stimulation for Executive Dysfunction After Traumatic Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: DEVICE: neuroConn_CE_DC-STIMULATOR|DEVICE: neuroConn_CE_DC-STIMULATOR|DEVICE: SHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study With Tumor Molecular Pharmacodynamic (MPD) Evaluation of Oral mTOR-inhibitor Everolimus (RAD001) 10 mg Daily in Patients Suffering From Classic or Endemic Kaposi's Sarcoma
Status: TERMINATED
Conditions: Kaposi Sarcoma
Interventions: DRUG: everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Treatment Efficacy of Suprascapular Nerve Block and Intraarticular Shoulder Injection Techniques in Patients Diagnosed With Adhesive Capsulitis
Status: COMPLETED
Conditions: Adhesive Capsulitis|Shoulder Pain
Interventions: PROCEDURE: Suprascapular Nerve Block|PROCEDURE: Intraarticular Shoulder Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Let's be Well Red: Efficacy of Gudness Bars in Improving the Hemoglobin and Hematocrit Levels of Anemic Subjects
Status: COMPLETED
Conditions: Treatment and Prevention of Anemia After Administration of Gudness Nutrition Bar
Interventions: DIETARY_SUPPLEMENT: Education plus Gudness Nutritional Bar|OTHER: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Real World Data on Vedolizumab Concentration and Outcomes in Inflammatory Bowel Disease (IBD) Patients Switching From Intravenous (IV) to Subcutaneous (SC) Vedolizumab in University Hospital Center Osijek
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|Crohn Disease|Colitis, Ulcerative
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: High Dose Atorvastatin for Preventing Periprocedural Ischemic Brain Damage During Carotid Artery Stenting
Status: UNKNOWN
Conditions: Carotid Artery Stenosis
Interventions: DRUG: High-dose Atorvastatin|DRUG: Conventional-dose Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Exparel Local Anesthetic in Total Knee Arthroplasty (TKA) Patients
Status: WITHDRAWN
Conditions: Osteoarthritis, Knee|Arthroplasty, Replacement, Knee
Interventions: DRUG: Liposomal bupivacaine, 266mg|DRUG: Bupivacaine 0.5 % with Epinephrine|DRUG: Ketorolac 30mg|DRUG: Morphine 10mg|DRUG: Bupivacaine 0.25% with Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Tirbanibulin Ointment in Adult Participants With Actinic Keratosis
Status: RECRUITING
Conditions: Keratosis, Actinic
Interventions: DRUG: Tirbanibulin|OTHER: Vehicle ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: KetoNiFast: Cyclic Enteral Daytime Feeding With Ketogenic Nighttime Fasting
Status: RECRUITING
Conditions: Nutrition|Muscle Loss|Inflammatory Response
Interventions: OTHER: Cyclic enteral feeding with nighttime fasting and exogenous ketone salt supplementation (ß-hydroxybutyrate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial of Laparoscopic Cholecystectomy vs. Non-operative Treatment for Gallbladder Dyskinesia
Status: UNKNOWN
Conditions: Gallbladder Dyskinesia
Interventions: PROCEDURE: Laparoscopic Cholecystectomy|DRUG: amitriptyline|OTHER: low-fat and low cholesterol diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Ambuja Cement Foundation Noncommunicable Disease Program in Bathinda District of Punjab, India
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Communicable Diseases|Blood Pressure|Behavior, Health|Blood Glucose, High|Blood Glucose, Low|Diabetes Type 2|Lifestyle-related Condition|Body Weight
Interventions: BEHAVIORAL: Ambuja Cement Foundation's Non Communicable Disease Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Donafenib Combined With Immunotherapy and Local Therapy for Unresectable Hepatocellular Carcinoma That Has Failed in Previous Therapy
Status: NOT_YET_RECRUITING
Conditions: Unresectable Hepatocellular Carcinoma
Interventions: DRUG: Donafenib|PROCEDURE: transhepatic arterial embolization chemotherapy or hepatic arterial infusion chemotherapy|DRUG: PD-1,PD-L1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Nitric Oxide for the Adjunctive Therapy of Severe Malaria: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Severe Malaria
Interventions: DRUG: Inhaled Nitric Oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Exposure to High Altitude on Blood and Tissue Oxygenation (ABGA, NIRS)
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: OTHER: Low altitude: 470m above sea level|OTHER: Säntis; 2500m above sea level
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Antidepressant Efficacy of the Anticholinergic Scopolamine
Status: TERMINATED
Conditions: Unipolar Depression|Bipolar Depression
Interventions: DRUG: Scopolamine|DRUG: Scopolamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Berberine Hyperglycemic Clamp
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Berberine Chloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cognitive Behavioral Therapy and Interpersonal Psychotherapy as Treatment for Major Depressive Disorder
Status: UNKNOWN
Conditions: Short Term Therapy for Outpatients Diagnosed With Major Depressive Disorder
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Interpersonal Psychotherapy (IPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Retinal Vessel Diameters and Red Blood Velocities in Patients With BRVO and Healthy Subjects
Status: UNKNOWN
Conditions: Branch Retinal Vein Occlusion|Retinal Blood Flow|Retinal Oxygen Saturation
Interventions: DEVICE: Dynamic Vessel Analyzer|OTHER: Bidirectional Fourier-Domain Optical Coherence Tomography (FDOCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Exploration of Stellate Ganglion Block in Patients With Cerebral Small Vessel Disease
Status: COMPLETED
Conditions: Cerebral Small Vessel Diseases
Interventions: BEHAVIORAL: Rehabilitation therapy|PROCEDURE: Stellate ganglion block|DRUG: Lidocaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Nitroglycerine Treatment for Radial Artery Spasm Prevention
Status: COMPLETED
Conditions: Radial Artery Spasm|Angina|Coronary Artery Disease
Interventions: DRUG: Topical Nitroglycerine|DRUG: Topical Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Ozone Therapy on Pain Perception After Free Gingival Graft Surgery in Patients With Mucogingival Defects
Status: COMPLETED
Conditions: Open Wound of Palate Without Complication|Pain, Postoperative|Free Gingival Grafts|Mucogingival Defects|Gingival Recession|Donor Site|Patient Satisfaction
Interventions: DEVICE: Ozone generator device (Ozone DTA-APOZAa-enterprize CO9-Taiwan, R.0.C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Poly Tetra Fluro Ethylene vs Native Collagen Membrane for Gbr in Anterior Maxilla
Status: UNKNOWN
Conditions: Missing Maxillary Anterior Teeth
Interventions: PROCEDURE: guided bone regenerations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of the Effects of Musical Training on Child Development in the Venezuela Orchestra Program (El Sistema)
Status: COMPLETED
Conditions: Child Development
Interventions: BEHAVIORAL: Treatment (Invited entry 2012)|BEHAVIORAL: Control (Invited entry 2013)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Emotional Freedom Technique (EFT) Applied to Postmenopausal Women on Sleep and Quality of Life
Status: NOT_YET_RECRUITING
Conditions: Menopause Related Conditions
Interventions: BEHAVIORAL: Emotional Freedom Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultrasound Guided Supracondylar Nerve Block & Hematoma Block for Closed Reduction of Distal End Radius Fractures
Status: COMPLETED
Conditions: Adults >18 Years With Distal End Radius Fracture Requiring Closed Reduction in Emergency Department
Interventions: OTHER: Hematoma block|OTHER: Supracondylar radial nerve block
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Arm Rehabilitation Study After Stroke
Status: COMPLETED
Conditions: Stroke|Brain Infarction|Brain Ischemia|Cerebral Infarction|Cerebrovascular Disorders
Interventions: BEHAVIORAL: Accelerated Skill Acquisition Program (ASAP)|BEHAVIORAL: Dose-Equivalent Usual & Customary Care - DEUCC|BEHAVIORAL: Usual and Customary Care - UCC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: DRUG: Teclistamab|DRUG: Pomalidomide|DRUG: Bortezomib|DRUG: Dexamethasone|DRUG: Carfilzomib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing Decision Maker Tools for Asthma: the Asthma APGAR
Status: UNKNOWN
Conditions: Asthma
Interventions: BEHAVIORAL: Use of Asthma APGAR system and tools|BEHAVIORAL: Asthma APGAR tools
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega 3 Fatty Acids in Patients With Chronic Renal Disease
Status: COMPLETED
Conditions: Renal Insufficiency, Chronic
Interventions: DIETARY_SUPPLEMENT: Omega 3 fatty acids|DIETARY_SUPPLEMENT: Corn oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Premedication With Melatonin and Alprazolam Combination Versus Alprazolam or Melatonin Alone
Status: COMPLETED
Conditions: Anxiety
Interventions: DRUG: meloset (melatonin)|DRUG: stresnil ( melatonin and alprazolam)|DRUG: (alprax) alprazolam|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PK of BV100 in Patients VABP Suspected or Confirmed to be Due to CRAB
Status: RECRUITING
Conditions: Ventilator Associated Pneumonia
Interventions: DRUG: BV100 plus Polymyxin B|DRUG: BAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Treatment of Gingivitis of Two Toothpastes
Status: COMPLETED
Conditions: Dental Plaque
Interventions: DRUG: Fluoride|DRUG: Triclosan|DRUG: Fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Pembrolizumab and Lenvatinib for Renal Cell Carcinoma
Status: RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Pembrolizumab infusion|DRUG: Lenvatinib tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise in Pediatric Autologous Stem Cell Transplant Patients
Status: TERMINATED
Conditions: Cancer|Autologous Hematopoietic Stem Cell Transplantation
Interventions: OTHER: EXERCISE (EX)|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Study to Evaluate the Effect of Aficamten Administration on QT/QTc Interval
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Aficamten|DRUG: Aficamten-matching Placebo|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Internet-delivered Cognitive Behavioural Therapy for Persons With Stroke
Status: NOT_YET_RECRUITING
Conditions: Stroke|Depression|Anxiety
Interventions: BEHAVIORAL: Guided internet delivered cognitive behavioural therapy|BEHAVIORAL: Stroke rehabilitation mental health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Antidepressants Alone
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Cariprazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Carvedilol in Treating Hypoglycemia Unawareness
Status: TERMINATED
Conditions: Hypoglycemia Unawareness
Interventions: DRUG: Carvedilol 3.125 mg|DRUG: Carvedilol 2.5 mg|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability and Pharmacokinetics of Modified-Release Formulations of AZD1446 After Oral Single and Repeated Doses
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD1446|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 (PASC) Using TSPO Positron Emission Tomography (PET) and MRI
Status: RECRUITING
Conditions: Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 Infection
Interventions: DRUG: PET Tracer|DRUG: MRI Tracer|DEVICE: 3T PET/MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Probiotics and Examination-related Stress in Healthy Medical Students
Status: COMPLETED
Conditions: Healthy|Stress-related Problem|Anxiety
Interventions: DIETARY_SUPPLEMENT: Lactobacillus rhamnosus GG (ATCC 53103)|DIETARY_SUPPLEMENT: Saccharomyces boulardii (CNCM I-1079)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Recurrence of Hereditary Hemorrhagic Telangiectasia (HHT) After Liver Transplantation
Status: COMPLETED
Conditions: Hereditary Haemorrhagic Telangiectasia|Liver Transplant
Interventions: OTHER: Data collection from standard follow-up after liver transplant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Robotic-assisted Total Knee Arthroplasty vs. Conventional One
Status: COMPLETED
Conditions: Osteo Arthritis Knee|Knee Arthritis|Knee Pain Chronic
Interventions: PROCEDURE: Total knee arthroplasty|DIAGNOSTIC_TEST: Computer tomography scan|DIAGNOSTIC_TEST: biomechanical assesment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: mFOLFIRINOX Followed by Hepatic Arterial Infusion of Floxuridine and Dexamethasone With Systemic mFOLFIRI for Unresectable Liver-dominant Intrahepatic Cholangiocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Liver and Intrahepatic Bile Duct Carcinoma|Stage III Intrahepatic Cholangiocarcinoma AJCC v8|Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8|Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8|Stage IV Intrahepatic Cholangiocarcinoma AJCC v8|Unresectable Intrahepatic Cholangiocarcinoma
Interventions: DRUG: Dexamethasone|DRUG: Floxuridine|DEVICE: Implanted Medical Device|DRUG: Irinotecan|DRUG: Leucovorin|DRUG: Oxaliplatin|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PD-1 Combined With Intensity Modulated Radiation Therapy in the Treatment of Intermediate-risk Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma|T2-3N0 or T1-2N1|EBV-DNA≤4000 Copy/ml
Interventions: DRUG: Toripalimab|PROCEDURE: Intensity modulated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cooling the Uterus in C-section After Dysfunctional Labor
Status: UNKNOWN
Conditions: Blood Loss|Dysfunctional Labor|Uterine Atony
Interventions: OTHER: Cold laparotomy sponges|DRUG: Pitocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of an Educational Intervention on Rehabilitation Clinicians' Practices for Health-related Outcomes After Stroke
Status: UNKNOWN
Conditions: Stroke|Knowledge, Attitudes, Practice|Physical Disability|Motor Skills Disorders
Interventions: OTHER: Implementation of stroke mobility guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial To Evaluate Reduning Injection in the Treatment of Mild Type of Hand, Foot, and Mouth Disease
Status: UNKNOWN
Conditions: Hand, Foot and Mouth Disease
Interventions: OTHER: Western therapy|OTHER: Reduning Injection|OTHER: Reduning Injection plus western therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability and Efficacy of CT1812 in Subjects With Mild to Moderate Dementia With Lewy Bodies
Status: ACTIVE_NOT_RECRUITING
Conditions: Dementia With Lewy Bodies
Interventions: DRUG: CT1812
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab, Cyclophosphamide, Vincristine and Prednisone (R-CHOP) Plus Metformin in Diffuse Large-B-cell Lymphoma
Status: COMPLETED
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of 48 Hour Course of Antibiotics to Prevent Surgical Site Infection in Obese Patients Undergoing Cesarean Delivery
Status: UNKNOWN
Conditions: Surgical Site Infection in Obese Women Undergoing C-section
Interventions: DRUG: cephalexin & metronidazole|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Pharmacokinetic Study Investigating the Rate and Extent of Paracetamol Absorption of Three Experimental Sustained Release Pediatric Suspensions
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Paracetamol fast dissolution suspension|DRUG: Paracetamol medium dissolution suspension|DRUG: Paracetamol slow dissolution suspension|DRUG: Paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Clinical Study to Evaluate Efficacy and Safety of TAK-385 40 mg Compared With Leuprorelin in Patients With Endometriosis
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: TAK-385|DRUG: Leuprorelin acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Pelareorep in Treating Patients With Advanced Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Adenocarcinoma|Stage III Pancreatic Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8
Interventions: BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Wild-type Reovirus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People With Type 2 Diabetes Compared to Weekly Insulin Icodec
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: IcoSema|DRUG: Insulin icodec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Early Review and Early Cardiac Rehabilitation After Coronary Artery Bypass
Status: COMPLETED
Conditions: Coronary Artery Disease|Quality of Life
Interventions: OTHER: Change in the timing of components of usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Courses of Lactobacilli Treatment on Bacterial Vaginosis and Pregnancy Outcomes
Status: UNKNOWN
Conditions: Bacterial Vaginosis
Interventions: DRUG: Vaginal capsules of lactobacilli|DRUG: Vaginal capsules of lactobacilli
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Patient Preference Study of Fluticasone Furoate and Mometasone Furoate Nasal Sprays
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial and Seasonal
Interventions: DRUG: FF nasal spray|DRUG: MF nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Anticholinergics on Cognitive Function in the Elderly
Status: COMPLETED
Conditions: Mental Competency|Urinary Bladder, Overactive|Cognitive Function
Interventions: DRUG: Trospium Chloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Laparoscopic Versus Open Orchiopexy in High Inguinal Undescended Testis, Prospective Randomized Clinical Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: We Conducted This Prospective Randomized Comparative Study to Compare Between Outcome of Laparoscopic and Open Orchiopexy of High Inguina
Interventions: PROCEDURE: laparoscopic orchiopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase Ib/II Study of BYL719 and Cetuximab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Status: TERMINATED
Conditions: Recurrent Head and Neck Squamous Cell Carcinoma|Metastatic Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: BYL719 as film-coated (FC) whole tablets|DRUG: BYL719 as dispersible tablets (DT)|BIOLOGICAL: cetuximab|DRUG: BYL719 drink suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT