pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Global Safety and Efficacy Registration Study of Crinecerfont in Pediatric Patients With Classic Congenital Adrenal Hyperplasia (CAHtalyst Pediatric Study)
Status: ACTIVE_NOT_RECRUITING
Conditions: Congenital Adrenal Hyperplasia
Interventions: DRUG: Crinecerfont|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Blood Loss Assessment in the Limited Application of Tourniquet During Primary Unilateral TKA
Status: COMPLETED
Conditions: Arthritis Knee|Blood Loss|Arthroplasty Complications
Interventions: PROCEDURE: primary unilateral total knee arthroplasty with limited application of tourniquet|PROCEDURE: primary unilateral total knee arthroplasty with full application of tourniquet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Completely Versus Partially Guided Zygomatic Implant
Status: RECRUITING
Conditions: Maxillary Deficiency|Alveolar Bone Loss
Interventions: PROCEDURE: completely limiting computer generated surgical three-dimensional guide|PROCEDURE: Partially limiting computer generated surgical three-dimensional guide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Delivering Transcutaneous Auricular Neurostimulation to Reduce Heavy Menstrual Bleeding in Von Willebrand Disease Patients
Status: RECRUITING
Conditions: Von Willebrand Disease, Type 1|Heavy Menstrual Bleeding
Interventions: DEVICE: Volta System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BE Study of the Fixed Dose Combination of 5 mg Saxagliptin and 500 mg Metformin HCl XR Tablet Relative to a 5 mg Saxagliptin (Onglyza™) Tablet and a 500 mg Metformin HCl XR (Glifage® XR Marketed in Brazil by Merck S.A.) Tablet Co-Administered to Healthy Subjects in the Fasted and Fed States
Status: WITHDRAWN
Conditions: Type 2 Diabetes
Interventions: DRUG: Saxagliptin|DRUG: Metformin XR|DRUG: Saxagliptin/Metformin XR FDC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: The Importance of Different Modularity of the Polyethylene Insert for Tibial Component Migration and Adaptive Bone Remodeling After Uncemented Total Knee Arthroplasty Using Trabecular Metal Technology (TMT) Zimmer NexGen®, (Monoblock vs. Modular Design)
Status: ACTIVE_NOT_RECRUITING
Conditions: Arthrosis of the Knee
Interventions: DEVICE: Zimmer NexGen® Trabecular Metal Technology (TMT), Monoblock|DEVICE: Zimmer NexGen® Trabecular Metal Technology (TMT), Modular
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Algorithm for Approaching Temporomandibular Disorders With Osteopathic Manual Therapy in Patients With Fibromyalgia
Status: RECRUITING
Conditions: Fibromyalgia|Temporomandibular Disorder
Interventions: OTHER: Osteopathic manual therapy|OTHER: Sham osteopathic manual therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Immunization Levels Against Sars-Cov2 Virus in Subjects Who Have Received EU-approved COVID-19 Vaccines
Status: COMPLETED
Conditions: SARS-CoV2 Infection|Vaccine Reaction
Interventions: BIOLOGICAL: Approved vaccines against Sars-Cov2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Personalized Dendritic Cell Vaccine Pilot for High Risk TNBC After Neoadjuvant Therapy
Status: RECRUITING
Conditions: Breast Cancer|Triple Negative Breast Cancer
Interventions: PROCEDURE: Leukapheresis|BIOLOGICAL: Dendritic Cell (DC) Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optical Coherence Tomography Imaging in Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis|Early Systemic Sclerosis Without Clinical Scleroderma and Onset < 2 Years
Interventions: DIAGNOSTIC_TEST: Non-invasive skin imaging assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients
Status: RECRUITING
Conditions: Cardiac Arrest, Out-Of-Hospital|Hypothermia, Induced|Hypoxia-Ischemia, Brain
Interventions: DEVICE: Therapeutic Hypothermia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ablation of Anisochronous Zones vs Spatio-temporal Dispersal Zones With Antral Electrical Isolation During Radiofrequency Treatment of Paroxysmal or Persistent Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Atrial fibrillation ablation|PROCEDURE: Atrial fibrillation ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regenerative Peripheral Nerve Interface for Prophylaxis Against Post-Breast Surgery Pain Syndrome
Status: NOT_YET_RECRUITING
Conditions: Post-mastectomy Pain Syndrome
Interventions: PROCEDURE: Regenerative Peripheral Nerve Interface
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of SHR2554 in Subjects With Relapsed or Refractory Mature Lymphoid Neoplasms
Status: UNKNOWN
Conditions: Relapsed or Refractory Mature Lymphoid Neoplasms
Interventions: DRUG: SHR2554
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study Between Ultrasound Guided Shoulder Block and Pericapsular Nerve Group Bock for Shoulder Arthroscopic Surgeries: Double Blinded Randomized Clinical Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Efficacy of PENG Block Managing Perioperative Pain With Shoulder Arthroscopy Surgeries|Efficacy of Shoulder Block in Managing Perioperative Pain With Shoulder Arthroscopy Surgeries
Interventions: PROCEDURE: Shoulder PENG block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EUS-guided Transenteric Drainage With a Novel Lumen-apposing Metal Stent
Status: COMPLETED
Conditions: Pancreatic Pseudocyst|Pancreatic Necrosis|Biliary Obstruction|Acute Cholecystitis
Interventions: DEVICE: EUS-guided drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Magnesium-rich Artificial Cerebrospinal Fluid in Subarachnoid Hemorrhage
Status: UNKNOWN
Conditions: Intracranial Hemorrhage
Interventions: OTHER: Magnesium-Rich Artificial Cerebrospinal Fluid (MACSF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Transabdominal Preperitoneal Surgical Repair of Inguinal Hernia Using Sutured Repair Versus Tacker Use
Status: COMPLETED
Conditions: Inguinal Hernia Unilateral
Interventions: OTHER: Titanium tacker|OTHER: Polypropylene 0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Application of Specific Frequencies to Stimulate the Spinocerebellar Tract in Subjects With Unilateral Dysafferentation
Status: COMPLETED
Conditions: Somatosensory Disorders
Interventions: DEVICE: Vibration Plate Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Functional Versus Core Stability Exercises on Pain and Sleep Quality in Patients With Primary Dysmenorrhea
Status: RECRUITING
Conditions: Primary Dysmenorrhea
Interventions: OTHER: Functional Exercises|OTHER: Core Stability Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Recombinant Oncolytic Adenovirus L-IFN Injection in Relapsed/Refractory Solid Tumors Clinical Study
Status: UNKNOWN
Conditions: Head and Neck Cancer|Melanoma|Breast Cancer|Bladder Cancer|Ovarian Carcinoma|Cervical Carcinoma|Lung Cancer
Interventions: DRUG: Recombinant L-IFN adenovirus injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiac Linear and Torsional Contractility Measurements With a New Technology: Multi Dimensional Kineticardiography
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Cardiac contractility assessments with Kino-cardiograph|DEVICE: Cardiac assessment repeatability with Kino-cardiograph
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effect of Remimazolam and Propofol on Hemodynamic Stability During Anesthesia Induction in OPCAB Patients
Status: COMPLETED
Conditions: Hemodynamic Instability
Interventions: DRUG: REMIMAZOLAM BESYLATE 2.5 Mg in 1 mL INTRAVENOUS INJECTION, POWDER, LYOPHILIZED, for SOLUTION [BYFAVO]|DRUG: Propofol|DRUG: Rocuronium|DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Manual Lymphatic Drainage on Pregnancy Induced Lumbo-Pelvic Pain
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: OTHER: Manual Lymphatic Drainage and Hot Pack|OTHER: Hot Pack
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbial Transplant for Alcohol Misuse in Cirrhosis
Status: COMPLETED
Conditions: Cirrhosis|Alcohol Abuse
Interventions: BIOLOGICAL: Fecal Microbial Transplant|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Versus Injectable Risperidone for Treating First-Episode Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Oral Risperidone|DRUG: Risperidone in Long-Acting Injectable Form (Consta)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrapleural Nebulization of Bupivacain to Reduce Postoperative Pain
Status: RECRUITING
Conditions: Lung Diseases
Interventions: DRUG: Intrapleural bupivacine nebulization|DRUG: Intravenous paracetamol and ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Atezolizumab in Combination With Bevacizumab, Carboplatin or Cisplatin, and Pemetrexed for EGFR-mutant Metastatic Non-small Cell Lung Cancer Patients After Failure of EGFR Tyrosine Kinase Inhibitors.
Status: ACTIVE_NOT_RECRUITING
Conditions: NSCLC Stage IIIB~IV
Interventions: DRUG: Atezolizumab Injection; bevacizumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Guided High Intensity Focused Ultrasound (MRgHIFU) for Pain Palliation of Bone Metastases
Status: WITHDRAWN
Conditions: Cancer|Bone Metastases
Interventions: DEVICE: Magnetic Resonance Image-guided High Intensity Focused Ultrasound (MR-HIFU)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Tele- or In-person Prehabilitation in Candidates Awaiting Total Hip or Knee Arthroplasty
Status: UNKNOWN
Conditions: Osteoarthritis
Interventions: BEHAVIORAL: 12-week prehabilitation program|DEVICE: Walking aid adjustment|BEHAVIORAL: Information about pain control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Th Effects of a Drug Dexmedotemidine in Regional Anesthesia in Participants Undergoing Upper Limb Surgeries
Status: RECRUITING
Conditions: Supraclavicular Brachial Plexus Block
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Swan-Ganz CCOmbo V for Obtaining an Optimal Depth of Right Internal Jugular Venous Catheter
Status: COMPLETED
Conditions: Insertion Depth of Central Venous Catheter
Interventions: DEVICE: Swan-Ganz Continuous Cardiac Output Thermodilutioon Cather (Swan-Ganz CCOmbo V)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adding Value in Knee Arthroplasty Post-total Knee Replacement (TKR) Care Navigator Trial
Status: COMPLETED
Conditions: Osteoarthritis|Degenerative Joint Disease
Interventions: BEHAVIORAL: Care Navigator|OTHER: Standard Post-Operative TKA Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Fixed Combination Therapy of Vildagliptin and Metformin (25/1000 mg Bid) in Patients With Type 2 Diabetes Inadequately Controlled With Prior Metformin Monotherapy (HbA1c 7.0-9.5%)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: vildagliptin + metformin|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: One-layer Versus Two-layer Duct-to-mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy
Status: UNKNOWN
Conditions: Pancreatic Fistula
Interventions: PROCEDURE: pancreaticojejunostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Non-inferiority Clinical Trial of Dexchlorpheniramine (Cream Versus Lotion) in the Relief of Sunburn Related Symptoms
Status: UNKNOWN
Conditions: Sunburn
Interventions: DRUG: Dexchlorpheniramine 1% lotion|DRUG: Dexchlorpheniramine 1% cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Depression & Insulin Sensitivity in Adolescents
Status: RECRUITING
Conditions: Type2 Diabetes|Type 2 Diabetes Mellitus|Insulin Sensitivity|Insulin Resistance|Depression|Adolescent Obesity
Interventions: BEHAVIORAL: Cognitive-behavioral therapy group|BEHAVIORAL: Health education group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Observational Post Authorisation Study to Evaluate Safety and Efficacy in Patients Receiving Azacitidine in Daily Clinical Practice in the Netherlands
Status: COMPLETED
Conditions: Myelodysplastic Syndromes|Leukemia, Myelomonocytic, Chronic|Leukemia, Myeloid, Acute
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Alveolar Recruitment Maneuvers on Reduction of Lung Atelectasis in Bariatric Surgery by Using Lung Ultrasound Score
Status: NOT_YET_RECRUITING
Conditions: Alveolar Recruitment Maneuvers|Atelectasis|Bariatric Surgery
Interventions: PROCEDURE: Lachmann maneuver|PROCEDURE: Staircase maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Umbilical Cord-derived Mesenchymal Stem Cells for Ischemic Stroke
Status: RECRUITING
Conditions: Ischemic Stroke
Interventions: BIOLOGICAL: Umbilical Cord-derived Mesenchymal Stem Cells|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reliability and Validity Study for SWE of Shoulder Muscles in Persons After Stroke.
Status: COMPLETED
Conditions: Stroke
Interventions: PROCEDURE: SWE assessor 1|PROCEDURE: SWE assessor 2|PROCEDURE: Stretch intervention|PROCEDURE: No stretch intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Short Course Nitrofurantoin for Acute Cystitis
Status: COMPLETED
Conditions: Urinary Tract Infection
Interventions: DRUG: Nitrofurantoin 100mg twice daily x 5 days|DRUG: TMP/SMX DS twice daily x 3 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hormone Secretion in Transgender Males
Status: NOT_YET_RECRUITING
Conditions: Transgender|Healthy
Interventions: DRUG: Testosterone Cyp 200Mg/Ml Inj (in Oil)|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: to Evaluate the Safety/Tolerability and Pharmacokinetics, and Pharmacodynamics of DWP14012 Injection
Status: NOT_YET_RECRUITING
Conditions: Erosive Gastroesophageal Reflux Disease
Interventions: DRUG: Fexuprazan Injection|DRUG: Fexuprazan Injection placebo|DRUG: Fexuprazan Injection_part 2|DRUG: Fexuprazan Injection_part 3|DRUG: Fexuprazan tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Fixation Achievable in Revision Total Knee Arthroplasty Implementing Latest-Generation Implant Technology
Status: COMPLETED
Conditions: Knee Osteoarthritis|Knee Arthroplasty
Interventions: DEVICE: Long-Stemmed with Hybrid Fixation|DEVICE: Short-Stemmed with Augmented Fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Xanthohumol and Prevention of DNA Damage
Status: COMPLETED
Conditions: Oxidative Stress
Interventions: DRUG: 6 mg xanthohumol per day|DRUG: 12 mg xanthohumol per day|DRUG: 24 mg xanthohumol per day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors
Status: COMPLETED
Conditions: Childhood Extracranial Germ Cell Tumor|Childhood Extragonadal Malignant Germ Cell Tumor|Childhood Malignant Ovarian Germ Cell Tumor|Childhood Malignant Testicular Germ Cell Tumor|Ovarian Choriocarcinoma|Ovarian Embryonal Carcinoma|Ovarian Yolk Sac Tumor|Recurrent Childhood Malignant Germ Cell Tumor|Recurrent Malignant Testicular Germ Cell Tumor|Recurrent Ovarian Germ Cell Tumor|Testicular Choriocarcinoma|Testicular Embryonal Carcinoma|Testicular Mixed Choriocarcinoma and Embryonal Carcinoma|Testicular Mixed Choriocarcinoma and Yolk Sac Tumor|Testicular Mixed Embryonal Carcinoma and Yolk Sac Tumor|Testicular Yolk Sac Tumor
Interventions: DRUG: Carboplatin|BIOLOGICAL: Filgrastim|DRUG: Ifosfamide|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Implementation Strategies for Cabotegravir (CAB)+ Rilpivirine (RPV) Long-acting (LA) Injectables for Human Immunodeficiency Virus (HIV)-1 Treatment in European Countries
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: CAB OLI|DRUG: CAB LA|DRUG: RPV OLI|DRUG: RPV LA|OTHER: Continuous Quality Improvement (CQI) calls
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Pharmacodynamic Properties of BIOD-105 and BIOD-107 Compared to Humalog® in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus Type 1
Interventions: DRUG: Insulin LISPRO|DRUG: recombinant human insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Evaluation of Switching From Ticagrelor to Prasugrel in Subjects With Stable Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Prasugrel Loading Dose|DRUG: Prasugrel Maintenance Dose|DRUG: Ticagrelor Maintenance Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism
Status: TERMINATED
Conditions: Subclinical Hypercortisolism|Cushing Syndrome|Adrenal Neoplasm
Interventions: PROCEDURE: Adrenalectomy|OTHER: Observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zalutumumab in Combination With Chemo-Radiation in a Certain Type of Lung Cancer
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: Zalutumumab|DRUG: Induction chemotherapy|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mediastinal Staging Accuracy of a Selective Lymphadenectomy Strategy in Early Stage NSCLC (ECTOP-1003)
Status: COMPLETED
Conditions: Lymph Node Metastases|Non-small Cell Lung Cancer Stage I
Interventions: DIAGNOSTIC_TEST: Intra-operative frozen section
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Study on Auricular Points Sticking Plus Chinese Medication for Hot Flashes in Breast Cancer Women
Status: UNKNOWN
Conditions: Breast Cancer|Hormonal Therapy|Hot Flashes|Acupuncture
Interventions: OTHER: Auricular Points Sticking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prevention of Nausea and Vomiting in Patients After Surgery
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Dexamethasone and aprepitant|DRUG: Dexamethasone and ondansetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PRONing to Facilitate Weaning From ECMO in Patients With Refractory Acute Respiratory Distress Syndrome
Status: COMPLETED
Conditions: ARDS
Interventions: PROCEDURE: Prone positionning|PROCEDURE: Supine position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erythematosus Study Protocol 2
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus (SLE)
Interventions: BIOLOGICAL: Blood sample|BIOLOGICAL: Urine sample|BIOLOGICAL: Saliva sample|BIOLOGICAL: Stool sample|BIOLOGICAL: Tissue sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Short Term Aspirin on the Biologic and Immunologic Changes of the Fallopian Tube
Status: ACTIVE_NOT_RECRUITING
Conditions: Fallopian Tube Cancer|Fallopian Tube Infection
Interventions: DRUG: Aspirin 81 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Vaccine (PDS0101) Alone or in Combination With Pembrolizumab for the Treatment of Locally Advanced Human Papillomavirus-Associated Oropharynx Cancer
Status: RECRUITING
Conditions: Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Human Papillomavirus-Related Carcinoma|Locally Advanced Oropharyngeal Carcinoma|Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Interventions: BIOLOGICAL: Liposomal HPV-16 E6/E7 Multipeptide Vaccine PDS0101|BIOLOGICAL: Pembrolizumab|PROCEDURE: Computed Tomography|PROCEDURE: FDG-Positron Emission Tomography|PROCEDURE: Biospecimen Collection|PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of the Combination of Azacitidine and Pembrolizumab for Patients Relapsed/Refractory Hodgkin's Lymphoma
Status: RECRUITING
Conditions: Hodgkin's Lymphoma
Interventions: DRUG: Azacytidine|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate a Single Dose of STI-2020 (COVI-AMG™) in Hospitalized Adults With COVID-19
Status: WITHDRAWN
Conditions: Covid19
Interventions: BIOLOGICAL: COVI-AMG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: IPL and Meibomian Gland Expression to Treat Ocular Rosacea Ocular GVHD
Status: COMPLETED
Conditions: GVHD|Ocular Rosacea|Dry Eye Syndrome
Interventions: DEVICE: IPL|PROCEDURE: Meibomian Gland Expression
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wide-Area Transepithelial Sampling in Endoscopic Eradication Therapy for Barrett's Esophagus
Status: RECRUITING
Conditions: Barrett Esophagus|Esophageal Cancer
Interventions: DEVICE: WATS-3D tissue sampling prior to forceps biopsies|DEVICE: WATS-3D tissue sampling following forceps biopsies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study Evaluating the Effect of Frozen-Section Directed Excision Surgery on Vulvar Dysplasia
Status: RECRUITING
Conditions: Vulvar Neoplasm|Dysplasia Vulvar
Interventions: PROCEDURE: Frozen-Section Directed Excision|PROCEDURE: Wide Local Excision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clareon PanOptix Pro vs. Clareon PanOptix - Study B
Status: RECRUITING
Conditions: Aphakia|Presbyopia
Interventions: DEVICE: CPO Pro IOL|DEVICE: CPO IOL|PROCEDURE: Cataract Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Levels of Salivary Paxillin Oral Premalignant and Malignant Lesions
Status: COMPLETED
Conditions: Comparison of Salivary Paxillin Levels in OPMLs and OSCC to Healthy Subjects
Interventions: DIAGNOSTIC_TEST: Paxillin biomarker
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Herbal Galactogogues in Breastfeeding Mothers
Status: UNKNOWN
Conditions: Weight Gain
Interventions: DIETARY_SUPPLEMENT: Still-Tee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Concomitant Basal Joint Arthroplasty and Carpal Tunnel Release
Status: UNKNOWN
Conditions: Carpal Tunnel Syndrome|Osteoarthritis Thumb
Interventions: PROCEDURE: Carpal tunnel release and basal joint arthroplasty through single incision|PROCEDURE: Carpal tunnel release and basal joint arthroplasty through double incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Pacemakers to Treat Slow Heart Rate in Patients With Heart Failure
Status: COMPLETED
Conditions: Heart Failure With a Preserved Ejection Fraction|Heart Failure, Diastolic|Chronotropic Incompetence
Interventions: DEVICE: Rate adaptive atrial pacing using a dual-chamber pacemaker|DEVICE: Pacemaker system will be implanted but set to Pacing Off.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Intervention Study of Stress Reduction in Corporate Health Management
Status: COMPLETED
Conditions: Stress, Psychological
Interventions: BEHAVIORAL: HRV_Bfb|BEHAVIORAL: MBI|BEHAVIORAL: MBI_HRV_Bfb
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Envafolimab Combined With Chemotherapy in Neoadjuvant Therapy for Resectable Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Envafolimab|DRUG: Albumin-Bound Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics Of Alprazolam Sublingual Tablet Versus Conventional Tablet
Status: COMPLETED
Conditions: Anxiety Disorder
Interventions: DRUG: Alprazolam tablet|DRUG: Alprazolam sublingual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of PZ01 Treatment in Patients With r/r CD19+ B-cell Acute Lymphoblastic Leukemia/B Cell Lymphoma
Status: UNKNOWN
Conditions: B-cell Acute Lymphoblastic Leukemia|B-cell Lymphoma
Interventions: DRUG: PZ01 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of Omega-3 Fatty Acid
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: OM3-supplement 1|DIETARY_SUPPLEMENT: OM3-supplement 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Research on the Characteristics and Application of Lactobacillus Rhamnosus X253 as Oral Probiotics
Status: COMPLETED
Conditions: Dental Caries
Interventions: BIOLOGICAL: Lactobacillus rhamnosus X253
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Investigate LYL797 in Adults with Solid Tumors
Status: RECRUITING
Conditions: Triple Negative Breast Cancer|TNBC - Triple-Negative Breast Cancer|Non-small Cell Lung Cancer|Non Small Cell Lung Cancer|Non Small Cell Lung Cancer Metastatic|Non-Small Cell Carcinoma of Lung, TNM Stage 4|Advanced Breast Cancer|Advanced Lung Carcinoma|NSCLC|NSCLC, Recurrent|NSCLC Stage IV|Relapsed Cancer|Relapse/Recurrence|Recurrent Breast Cancer|Recurrent NSCLC|Platinum-resistant Ovarian Cancer|Ovarian Cancer|Primary Peritoneal Carcinoma|Fallopian Tube Cancer|Endometrial Cancer|Endometrioid Tumor|High Grade Serous Carcinoma|Ovarian Epithelial Cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Renalof® in the Removal of Calculi Smaller Than 10 mm Located in the Reno-Ureteral Tract
Status: COMPLETED
Conditions: Renal Injury|Kidney Injury|Kidney Calculi|Ureteral Obstruction|Ureteral Calculi|Renal Stone|Ureteral Injury|Renal Disease|Urolithiasis, Calcium Oxalate|Urolithiasis; Lower Urinary Tract|Urolithiasis
Interventions: DIETARY_SUPPLEMENT: Renalof|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vudalimab (XmAb20717) in Combination With Standard of Care Treatment in Patients With Metastatic Castration Sensitive Prostate Cancer
Status: RECRUITING
Conditions: Castration-Sensitive Prostate Carcinoma|Metastatic Prostate Adenocarcinoma|Stage IVB Prostate Cancer AJCC v8
Interventions: DRUG: Abiraterone|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|DRUG: Docetaxel|DRUG: Enzalutamide|PROCEDURE: FDG-Positron Emission Tomography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: PSMA PET Scan|DRUG: Vudalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tenecteplase Pulmonary Embolism Italian Study
Status: TERMINATED
Conditions: Pulmonary Embolism
Interventions: DRUG: tenecteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-label Study of DS-8273a to Assess Its Safety and Tolerability, and Assess Its Pharmacokinetic and Pharmacodynamic Properties in Subjects With Advanced Solid Tumors or Lymphomas
Status: COMPLETED
Conditions: Advanced Solid Tumor|Lymphoma
Interventions: DRUG: DS-8273a
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Ezetimibe and Atorvastatin Coadministration Versus Atorvastatin or Rosuvastatin Monotherapy in Japanese Patients With Hypercholesterolemia (Study P06027)(COMPLETED)
Status: COMPLETED
Conditions: Primary Hypercholesterolemia
Interventions: DRUG: Ezetimibe|DRUG: Atorvastatin|DRUG: Atorvastatin|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transdermal Estradiol and Exercise in Mitigating Adverse Effects of Androgen Deprivation Therapy for Prostate Cancer Radiation Therapy
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Transdermal estrogen|DRUG: Active Comparator: Androgen deprivation therapy|BEHAVIORAL: Resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vapreotide in Treating Patients Undergoing Elective Pancreatic Resection
Status: TERMINATED
Conditions: Pancreatic Cancer|Perioperative/Postoperative Complications
Interventions: DRUG: vapreotide|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Acute, Unstable Chest Wall Injuries
Status: UNKNOWN
Conditions: Blunt Injury of Thorax|Flail Chest|Chest Wall Injury Trauma|Rib Fracture
Interventions: PROCEDURE: Surgical fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of a Subcutaneous Formulation of Efgartigimod PH20 SC in Adults With Pemphigus (Vulgaris or Foliaceus)
Status: COMPLETED
Conditions: Pemphigus Vulgaris|Pemphigus Foliaceus
Interventions: BIOLOGICAL: efgartigimod PH20 SC|OTHER: Placebo|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Study to Compare Multiple Doses of Intravitreal Microplasmin Versus Sham Injection for Treatment of Patients With Diabetic Macular Edema (DME)
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: ocriplasmin|OTHER: Sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Breakfast Meal Containing Oat β-glucan on Food Intake at a Subsequent Meal in Normal-weight and Overweight Subjects
Status: COMPLETED
Conditions: Satiety
Interventions: OTHER: Oatmeal + OatWell28CF Int 1|OTHER: Oatmeal + OatWell28CF Int 2|OTHER: Oatmeal + OatWell28CF Int 3|OTHER: Cream of Rice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Diabetic Foot Surgery Patients: What is Their Metabolic Profile and Are Nutritional Goals Met
Status: SUSPENDED
Conditions: Diabetic Foot Ulcer|Nutrition Disorders
Interventions: DIAGNOSTIC_TEST: Metabolic profile and nutritional goals in diabetic foot surgery patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamics of E2025 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: E2025|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety & Efficacy of a Combination Niacin ER/Simvastatin in Patients With Dyslipidemia: A Dose-Ranging Study - SEACOAST
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Niacin extended release and simvastatin tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiation Therapy in Treating Patients With Low- and Intermediate-Risk Prostate Cancer
Status: TERMINATED
Conditions: Prostate Adenocarcinoma|Stage I Prostate Cancer
Interventions: RADIATION: stereotactic body radiation therapy|RADIATION: four fraction split-course SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nelfinavir Mesylate in Treating Patients With Kaposi Sarcoma
Status: COMPLETED
Conditions: Recurrent Kaposi Sarcoma|Skin Kaposi Sarcoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Nelfinavir Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rheumatologists and the Requesting of Antinuclear Antibodies (ANA) Tests in Patients With Rheumatologic Complaints
Status: COMPLETED
Conditions: Rheumatic Diseases
Interventions: BEHAVIORAL: Education and feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Radiation Therapy Combined With Either Gefitinib or Temozolomide in Pats With NSCLC and Brain Metastases
Status: COMPLETED
Conditions: Lung Cancer|Metastatic Cancer
Interventions: DRUG: gefitinib|DRUG: temozolomide|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation for Treatment of Gastrointestinal Dysbiosis or Clearance of ARO
Status: TERMINATED
Conditions: Dysbiosis|Antimicrobial Resistant Organism
Interventions: BIOLOGICAL: Fecal Microbiota Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Investigate the Safety, Tolerability and Efficacy of ABT-122 in Subjects With Active Psoriatic Arthritis (PsA) Who Have an Inadequate Response to Methotrexate (MTX)
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: BIOLOGICAL: adalimumab|BIOLOGICAL: ABT-122
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Galvus in Elderly Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Vildagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing IOP-Lowering Treatments to Bimatoprost in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma, Open-Angle|Ocular Hypertension
Interventions: DRUG: Bimatoprost
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Efficacy and Safety of Aricept in Patients With Severe Alzheimer's Disease Who Are Living in Skilled Nursing Homes
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Donepezil (Aricept)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of PN2034 in Type 2 Diabetes Patients on Concomitant Rosiglitazone and Metformin (or Avandamet)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: rosiglitazone|DRUG: metformin|DRUG: PN2034
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of Mulligan Technique With or Without Diclofenac Phonophoresis on Patellofemoral Pain Syndrome.
Status: RECRUITING
Conditions: Patellofemoral Pain Syndrome
Interventions: COMBINATION_PRODUCT: Group 1|COMBINATION_PRODUCT: Group 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of TAS5315 Compared With Placebo in Participants With Rheumatoid Arthritis.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: TAS5315 low dose|DRUG: TAS5315 high dose|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Risk of Developing Type II Diabetes Using Serum Biomarkers in Patients Diagnosed With Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Diabetes Mellitus
Interventions: BEHAVIORAL: PreDx Diabetes Risk Score
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Petrolatum's Effect on Initial Symptoms of Nonscalp Seborrheic Dermatitis and Preventing Exacerbation
Status: TERMINATED
Conditions: Seborrheic Dermatitis
Interventions: BIOLOGICAL: Petroleum Jelly
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SH L 562BB Phase II/III Dose Justification and Gadoteridol-controlled Comparative Study
Status: COMPLETED
Conditions: Brain Metastases
Interventions: DRUG: Gadobutrol (Gadavist, Gadovist, BAY86-4875)|DRUG: Gadobutrol (Gadavist, Gadovist, BAY86-4875)|DRUG: ProHance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Virtual Reality-Based Attention Bias Modification Training for Anorexia Nervosa (AN-VR-ABM)
Status: COMPLETED
Conditions: Anorexia Nervosa
Interventions: BEHAVIORAL: Attentional Bias Modification Training|BEHAVIORAL: VR-based body exposure|BEHAVIORAL: Cognitive-behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Indobufen and Aspirin on Platelet Aggregation and Long Term Prognosis in Patients With Coronary Heart Disease
Status: UNKNOWN
Conditions: Stable Coronary Heart Disease
Interventions: DRUG: Indobufen|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Antibiotic Therapy in Treating Patients With Low Grade Gastric Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DIETARY_SUPPLEMENT: bismuth subcitrate|DRUG: amoxicillin|DRUG: clarithromycin|DRUG: metronidazole hydrochloride|DRUG: omeprazole|DRUG: tetracycline hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study to Evaluate an Experimental New Treatment (CALY-002) in Healthy Subjects and Subjects With Celiac Disease and Eosinophilic Esophagitis
Status: COMPLETED
Conditions: Eosinophilic Esophagitis|Celiac Disease
Interventions: BIOLOGICAL: CALY-002|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ketogenic Diet for Promoting Weight Loss in Obese Individuals With Compensated NASH Cirrhosis
Status: ACTIVE_NOT_RECRUITING
Conditions: NASH - Nonalcoholic Steatohepatitis|Cirrhosis, Liver
Interventions: OTHER: Dietary consult for participants in the ketogenic diet arm|OTHER: Dietary consult for participants in the standard of care arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Health and Migration Trajectories of Housekeepers in Bamako
Status: COMPLETED
Conditions: HIV Infections|Hepatitis B|Hepatitis C|Tuberculosis|STIs|Sex Behavior
Interventions: OTHER: Community-based healthcare offer provided by an the ARCAD Santé PLUS NGO and integrated into the activities of the ADDAD NGO
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Carboplatin and DOXIL Plus Bevacizumab in Patients With Platinum Sensitive Recurrent Ovarian, Fallopian Tube and Primary Peritoneal Cancers
Status: COMPLETED
Conditions: Ovarian Neoplasms|Fallopian Tube Neoplasms|Peritoneal Neoplasms
Interventions: DRUG: doxorubicin HCL liposome; bevacizumab; carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT