pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Direct Measurement of Motor Cortical Responses to tDCS
Status: ENROLLING_BY_INVITATION
Conditions: Parkinson Disease|Chronic Stroke
Interventions: DEVICE: transcranial direct current stimulation (noninvasive recording)|DEVICE: sham transcranial direct current stimulation (noninvasive recording)|DEVICE: transcranial direct current stimulation (invasive recording)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Analysis of the Risk Factors for the Neutropenic Fever in the High Risk NHL Patients for Developing Febrile Neutropenia Who Received 3-weekly CHOP-like Chemotherapy With Primary G-CSF Prophylaxis; Prospective Multicenter Observation Study
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase II Trial of Neo-Adjuvant Pemetrexed Plus Cisplatin Followed by Surgery and Radiation for Pleural Mesothelioma
Status: COMPLETED
Conditions: Pleural Neoplasms
Interventions: DRUG: pemetrexed|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre- and Intra-operative Intravitreal Bevacizumab Injection in Diabetic Vitrectomy
Status: COMPLETED
Conditions: Proliferative Diabetic Retinopathy|Vitreous Hemorrhage
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib/II Study of LGX818 in Combination With MEK162 in Adult Patients With BRAF Dependent Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors Harboring a BRAF V600 Mutation
Interventions: DRUG: LGX818|DRUG: MEK162|DRUG: LEE011
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Influence of Various Healing Intervals on Alveolar Ridge Preservation Using Demineralized Dentin Graft: A Randomized Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Dentin Graft, Alveolar Ridge Preservation
Interventions: BIOLOGICAL: Dentin Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Investigate Efficacy of LAS41004 in Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Experimental: LAS 41004 dosage 1|DRUG: Experimental: LAS 41004 dosage 2|DRUG: Experimental: LAS 41004 dosage 3|DRUG: Placebo Comparator: placebo|DRUG: Reference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Single-arm, Phase II Clinical Trial to Evaluate the Efficacy and Safety of Tafolecimab and Sintilimab Combined With Chemotherapy in Patients With Advanced or Metastatic Driver Gene-negative Non-small Cell Lung Cancer After Failure of First-line Immunotherapy.
Status: RECRUITING
Conditions: Lung Cancer
Interventions: DRUG: Tafolecimab|DRUG: Sintilimab|DRUG: Nab paclitaxel|DRUG: Docetaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of GSK Biologicals' Meningococcal Conjugate Vaccine When Co-administered With Routine Vaccines in Healthy Infants and Toddlers
Status: COMPLETED
Conditions: Meningococcal Infection
Interventions: BIOLOGICAL: Meningococcal vaccine GSK 134612|BIOLOGICAL: SynflorixTM|BIOLOGICAL: Infanrix-IPV/HiberixTM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 1 Study of RO7623066 Alone and in Combination in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: RO7623066|DRUG: Olaparib|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Key Model Of Courtesy And Integrıty
Status: UNKNOWN
Conditions: Psychotherapy|Communication
Interventions: OTHER: Kindness and honesty psychoeducation based on positive psychotherapy: The Key Model Of Courtesy And Integrity (KMCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Plasma Concentrations of Levobupivacaine With and Without Epinephrine in Transversus Abdominis Plane Blocks
Status: COMPLETED
Conditions: Transversus Abdominis Plane Block
Interventions: DRUG: Levobupivacaine with epinephrine|DRUG: Levobupivacaine without epinephrine|OTHER: Monitoring|OTHER: Determining the extent of the block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Feasibility Study of Transcranial Ultrasound Stimulation on Alzheimer's Disease Patients
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: DEVICE: Transcranial Ultrasound Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Neurocognitive Effects of Ziprasidone: Relationship to Working Memory and Dopamine Blockade
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: ziprasidone vs risperidone or olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ecopipam Treatment of Tourette's Syndrome in Subjects 7-17 Years
Status: COMPLETED
Conditions: Tourette's Syndrome
Interventions: DRUG: Ecopipam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Evaluation of a Vaginal Bowel Control System for the Treatment of Fecal Incontinence in Women (LIFE)
Status: COMPLETED
Conditions: Fecal Incontinence
Interventions: DEVICE: vaginal bowel control system (LivSure)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ifosfamide and Topotecan in Treating Patients With Refractory Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: ifosfamide|DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Blueberries on Cognition and Body Composition in Elderly With Mild Cognitive Decline
Status: COMPLETED
Conditions: Mild Cognitive Decline
Interventions: DIETARY_SUPPLEMENT: Freeze-dried blueberries|DIETARY_SUPPLEMENT: Dextrose Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prevention of Clostridium Difficile-associated Diarrhea by Daily Intake of Kefir
Status: TERMINATED
Conditions: Clostridium Difficile Infection|Diarrhea
Interventions: DRUG: kefir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Person-Centered, Occupation Based Therapy for Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Occupational Therapy
Interventions: BEHAVIORAL: Person centered, occupation based intervention support with problem solving therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Optimization of a New Adaptive Intervention to Increase COVID-19 Testing
Status: COMPLETED
Conditions: COVID-19 Testing
Interventions: BEHAVIORAL: Navigation Services|BEHAVIORAL: Critical Dialogue|BEHAVIORAL: Brief Counseling|BEHAVIORAL: Referral and Digital Brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ADRCs in The Treatment of Hand Dysfunction Due to Scleroderma
Status: NOT_YET_RECRUITING
Conditions: Scleroderma, Diffuse
Interventions: DEVICE: ADRCs|OTHER: Standard Care|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of the Rex Medical -Closer™ Vascular Closure System -Reduced Time to Ambulation Trial
Status: COMPLETED
Conditions: Bleeding
Interventions: DEVICE: Rex Medical Closer™ Vascular Closure System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor|Adult Central Nervous System Germ Cell Tumor|Adult Rhabdomyosarcoma|Childhood Central Nervous System Germ Cell Tumor|Childhood Soft Tissue Sarcoma|Ewing Sarcoma|Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Ovarian Mixed Germ Cell Tumor|Previously Untreated Childhood Rhabdomyosarcoma|Recurrent Adult Brain Tumor|Recurrent Adult Soft Tissue Sarcoma|Recurrent Childhood Brain Stem Glioma|Recurrent Childhood Cerebellar Astrocytoma|Recurrent Childhood Cerebral Astrocytoma|Recurrent Childhood Ependymoma|Recurrent Childhood Malignant Germ Cell Tumor|Recurrent Childhood Medulloblastoma|Recurrent Childhood Pineoblastoma|Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor|Recurrent Childhood Visual Pathway and Hypothalamic Glioma|Recurrent Childhood Visual Pathway Glioma|Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Recurrent Extragonadal Germ Cell Tumor|Recurrent Extragonadal Non-seminomatous Germ Cell Tumor|Recurrent Malignant Testicular Germ Cell Tumor|Recurrent Neuroblastoma|Recurrent Ovarian Germ Cell Tumor|Recurrent Wilms Tumor and Other Childhood Kidney Tumors|Unspecified Adult Solid Tumor, Protocol Specific|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: busulfan|DRUG: melphalan|DRUG: topotecan hydrochloride|OTHER: laboratory biomarker analysis|BIOLOGICAL: filgrastim|PROCEDURE: autologous hematopoietic stem cell transplantation|OTHER: pharmacological study|PROCEDURE: autologous bone marrow transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Impact of Concomitant Use of Multiple Doses of Clopidogrel With Multiple Doses of Dabigatran Etexilate on the Pharmacokinetic and Pharmacodynamic Parameters in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Clopidogrel|DRUG: Dabigatran high dose|DRUG: Dabigatran low dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Deep Brain Stimulation for Severe Anorexia Nervosa
Status: ACTIVE_NOT_RECRUITING
Conditions: Severe Enduring Anorexia Nervosa
Interventions: DEVICE: DBS to nucleus accumbens/anterior limb of internal capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures
Status: RECRUITING
Conditions: Depression in Old Age|Fragility Fracture
Interventions: DRUG: Duloxetine 30 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Anifrolumab PK Study for Systemic Lupus Erythematosus (SLE)
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: Anifrolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Canagliflozin on Intravascular Volume and Hemodynamics
Status: WITHDRAWN
Conditions: Type2 Diabetes Mellitus|Cardiovascular Diseases
Interventions: DRUG: Canagliflozin 300mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: ViDES Trial (Vitamin D Extra Supplementation)
Status: RECRUITING
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: 800 IU/day vitamin D supplementation with feedings in the first 28 days after birth|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of PEG-EPO Injection (CHO Cells) for Maintenance Therapy of Patients With Renal Anemia .
Status: RECRUITING
Conditions: Renal Anemia
Interventions: BIOLOGICAL: Recombinant human erythropoietin injection|BIOLOGICAL: Human erythropoietin injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiolabeled Monoclonal Antibody Plus Rituximab With and Without Filgrastim and Interleukin-11 in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Splenic Marginal Zone Lymphoma|Waldenström Macroglobulinemia
Interventions: BIOLOGICAL: rituximab|BIOLOGICAL: yttrium Y 90 ibritumomab tiuxetan|BIOLOGICAL: indium In 111 ibritumomab tiuxetan|BIOLOGICAL: oprelvekin|BIOLOGICAL: filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Antibiotic Requirements Following Immediate Breast Reconstruction
Status: COMPLETED
Conditions: Bacterial Infection|Anti-infective Agents|Breast Implantation
Interventions: DRUG: Cefadroxil discontinued early|DRUG: Cefadroxil until drain removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Cetuximab in Combination With Carboplatin and Docetaxel for Patients With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Addition of a Power Interdental Device to an Electric Toothbrush on Gingival Health.
Status: COMPLETED
Conditions: Gingivitis
Interventions: DEVICE: Electric toothbrush|DEVICE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Short Questionnaire to Assess Individual Needs in Cancer Survivors in a Clinical Setting
Status: ENROLLING_BY_INVITATION
Conditions: Cancer Survivors
Interventions: BEHAVIORAL: Active intervention|BEHAVIORAL: Low-intensity intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tubeless Versus Standard Upper Pole Percutaneous Nephrolithotomy
Status: COMPLETED
Conditions: Pleural Effusion
Interventions: DEVICE: Double J stent without nephrostomy|DEVICE: nephrostomy tube and double J stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Electronic Symptom Monitoring Program for Triggered Palliative Referrals in Patients With Thoracic Cancer
Status: RECRUITING
Conditions: Malignant Thoracic Neoplasm
Interventions: OTHER: Educational Activity|OTHER: Electronic Health Record Review|OTHER: Internet-Based Intervention|OTHER: Media Intervention|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Nonselective Beta Blocker vs Placebo in Patients With Acute-on-chronic Liver Failure With Small/ no Esophageal Varices
Status: COMPLETED
Conditions: Acute on Chronic Liver Failure
Interventions: DRUG: Carvedilol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Study of Serum Testosterone Levels in Non-dosed Females After Secondary Exposure to Testosterone Gel 1.62% Applied to the Upper Arms and Shoulders and Use of a T-shirt Barrier
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Testosterone Gel 1.62%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Fixed-Sequence, Drug-Drug Interaction Study Between Multiple Oral Doses of Inarigivir Soproxil and a Single Oral Dose of Midazolam in Healthy Subjects
Status: COMPLETED
Conditions: Drug Interaction Potentiation
Interventions: DRUG: Midazolam|DRUG: Inarigivir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.
Status: RECRUITING
Conditions: Malignant Glioma of Brain|Astrocytoma|Malignant Astrocytoma|Brain Tumor|Glioma|Brain Cancer|Glioblastoma|Glioblastoma Multiforme|GBM
Interventions: BIOLOGICAL: Ad5-yCD/mutTKSR39rep-ADP adenovirus and fractionated stereotactic radiosurgery (fSRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMPACT: IMPact of Antimalarials on Covid-19 Infections in RAPPORT
Status: COMPLETED
Conditions: Covid-19 Infection|Rheumatoid Arthritis|Psoriatic Arthritis|Hydroxychloroquine
Interventions: OTHER: Hydroxychloroquine/Chloroquine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ampicillin and Ceftriaxone for the Treatment of Enterococcus Faecalis Infective Endocarditis.
Status: NOT_YET_RECRUITING
Conditions: Endocarditis, Infective
Interventions: DRUG: Experimental regimen|DRUG: Control regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-directed Titrated Transdermal Nicotine Patch Versus Standard Treatment for Smoking Cessation
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: NicoDerm Patch|DRUG: Nicorette Inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Lifestyle Modification on Cardiovascular Risk
Status: RECRUITING
Conditions: Metabolic Syndrome|Menopause|Cardiovascular Diseases|Obesity|Type2diabetes
Interventions: OTHER: Exercise Only (Ex only)|OTHER: Exercise and Mediterranean Diet (Ex + MedDiet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of CAM-3001 (Drug) in Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Mavrilimumab 10 mg|BIOLOGICAL: Mavrilimumab 30 mg|BIOLOGICAL: Mavrilimumab 50 mg|BIOLOGICAL: Mavrilimumab 100 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The INSPIRE Trial: A Study of Interferon Gamma-1b for Idiopathic Pulmonary Fibrosis (IPF)
Status: TERMINATED
Conditions: Idiopathic Pulmonary Fibrosis|Lung Disease|Pulmonary Fibrosis
Interventions: DRUG: Interferon gamma-1b ("Actimmune")
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Skeletal Muscle Strain Injuries and the Connective Tissue: Characterization, Recovery and Optimal Treatment
Status: COMPLETED
Conditions: Muscle Strain
Interventions: PROCEDURE: Acute Early onset of rehabilitation|PROCEDURE: Acute Delayed onset of rehabilitation|PROCEDURE: Chronic Exercise|PROCEDURE: Chronic Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Training in Rural Schools
Status: COMPLETED
Conditions: Behavior Disorders
Interventions: BEHAVIORAL: Coping Power Program (CPP)|BEHAVIORAL: Cognitive behavioral therapy (CBT) for Anxiety Treatment in Schools (CATS)|BEHAVIORAL: Check-in/Check-out (CI/CO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Whole Genome Sequencing (ChromoSeq) as an Adjunct to Conventional Genomic Profiling in MDS
Status: RECRUITING
Conditions: Whole Genome Sequencing|Myelodysplastic Syndromes
Interventions: DEVICE: ChromoSeq
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Increasing Treatment Efficacy Using SMART Methods for Personalizing Care
Status: COMPLETED
Conditions: Anxiety Disorders|Post Traumatic Stress Disorder|Obsessive-Compulsive Disorder
Interventions: BEHAVIORAL: Standard UP Treatment|BEHAVIORAL: Capitalization UP Treatment|BEHAVIORAL: Compensation UP Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin C Supplementation as a Preventive Treatment of Diabetic Peripheral Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathies
Interventions: DIETARY_SUPPLEMENT: Vitamin C|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Immune-modulatory Effect of Probiotic Strain on Grass Pollen Allergic Individuals
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DIETARY_SUPPLEMENT: Maltodextrin|DIETARY_SUPPLEMENT: Probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Calcitriol for the Treatment of Lupus Nephritis and Persistent Proteinuria
Status: WITHDRAWN
Conditions: Systemic Lupus Erythematosus|Nephritis|Proteinuria
Interventions: DRUG: Calcitriol|DRUG: Multivitamin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Cortical Bone Mechanics Technology (CBMT) Fracture Discrimination Capability
Status: COMPLETED
Conditions: Osteoporosis|Osteopenia or Osteoporosis|Osteoporosis, Postmenopausal|Osteoporosis Risk|Osteoporotic Fractures|Fragility Fracture|Bone Fracture
Interventions: DIAGNOSTIC_TEST: Cortical Bone Mechanics Technology
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Rituximab in Comparison to Continued Corticosteroid Treatment in Idiopathic Nephrotic Syndrome
Status: UNKNOWN
Conditions: Idiopathic Nephrotic Syndrome|Minimal Change Disease|Focal Segmental Glomerulosclerosis
Interventions: DRUG: Rituximab|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Spinal Epidural Anesthesia in Obese Patients Undergoing Cesarean Surgery
Status: COMPLETED
Conditions: Obesity|Pregnancy Related|Cesarean Section Complications|Spinal Anaesthetic Poisoning of Undetermined Intent|Hypotension
Interventions: OTHER: left lateral decubitus position|OTHER: sitting position|DRUG: The use of intravenous ephedrine.|DRUG: The use of intravenous atropine.|DRUG: The use of intravenous metoclopramide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Radiofrequency Ablation Plus Radiotherapy for Small Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Radiofrequency ablation with radiotherapy|DRUG: Radiofrequency ablation alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML)
Status: COMPLETED
Conditions: AML
Interventions: DRUG: Sirolimus|DRUG: Mitoxantrone|DRUG: Etoposide|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Non-invasive Ventilation (NIV) on Cerebral Oxygenation.
Status: UNKNOWN
Conditions: Cerebral Oxygenation
Interventions: PROCEDURE: Non-invasive ventilation with different FiO2 settings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase Ⅲ Clinical Study of Combined Cisplatin Versus Placebo Combined With Intracavitary Cisplatin Injection in the Treatment of Malignant Pleural Effusions
Status: UNKNOWN
Conditions: Malignant Pleural Effusion
Interventions: DRUG: ENDOSTAR，cisplatin|DRUG: Placebo , cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Examining Behavior Therapy for Trichotillomania in Children and Adolescents
Status: COMPLETED
Conditions: Trichotillomania
Interventions: BEHAVIORAL: Behavior Therapy|BEHAVIORAL: Supportive Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Multiple Ascending Dose and Multi-Dose of DT-216 in Adult Patients With Friedreich Ataxia
Status: COMPLETED
Conditions: Friedreich Ataxia
Interventions: DRUG: DT-216|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LEAP2 on Postprandial Glucose Metabolism and Food Intake n Obese Males
Status: RECRUITING
Conditions: Obesity
Interventions: DRUG: LEAP-2 Protein, Human
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Glucose Consumption During Deep Brain Stimulation With Functional [18F]FDG-Brain-PET in Obsessive-Compulsive Disorder
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder|Psychiatric Disorder
Interventions: DEVICE: Implantation of a DBS therapy system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peripheral Blood Stem Cell Transplant (PBSCT) in Children With High Risk or Recurrent Solid Tumors
Status: TERMINATED
Conditions: High Risk Solid Tumors|Recurrent Solid Tumors
Interventions: PROCEDURE: Peripheral Blood Stem Cell Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing CGM and OGTT in Relation to Iron Overload Detected by Pancreas T2* MRI in High-Risk Hematology Group
Status: WITHDRAWN
Conditions: Iron Overload|Hemoglobinopathies|Lymphoma|Acute Lymphoblastic Leukemia
Interventions: DIAGNOSTIC_TEST: Continuous Glucose Monitoring (CGM)|DIAGNOSTIC_TEST: Oral Glucose Tolerance Test (OGTT)|DIAGNOSTIC_TEST: T2* MRI of the Pancreas
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy & Safety of Submucosal Endoscopic Myotomy With Mucosal Flap (SEMF) in the Treatment of Patients With Achalasia
Status: COMPLETED
Conditions: Achalasia|Dysphagia
Interventions: PROCEDURE: Submucosal endoscopic myotomy with mucosal flap technique|PROCEDURE: Submucosal Endoscopic Mucosal Flap (SEMF) technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Automated and Personalized Cognitive Behavioral Therapy
Status: COMPLETED
Conditions: Depressive Symptoms
Interventions: BEHAVIORAL: Interactive and personalized CCBT|BEHAVIORAL: Feature-limited CCBT|OTHER: Waitlist control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study Evaluating Temsirolimus (CCI-779) In Mantle Cell Lymphoma (MCL)
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Temsirolimus (CCI-779)|DRUG: Temsirolimus (CCI-779)|DRUG: Investigator's choice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Pulmonary Compliance Optimization Through PEEP Manipulations Reduces the Incidence of Postoperative Hypoxaemia in Bariatric Surgery?
Status: COMPLETED
Conditions: Bariatric Surgery
Interventions: DEVICE: PEEP (positive end-expiratory pressure)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Switch From the Original Infliximab to Its Biosimilar in Daily Practice at Cochin Hospital
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Spondyloarthritis|Crohn's Disease|Uveitis
Interventions: OTHER: Switch from REMICADE® to INFLECTRA®
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevention for the Restenosis of Intracranial Artery Stent Implantation Treated With Herbal Medicine C117
Status: UNKNOWN
Conditions: Occlusion and Stenosis of Unspecified Cerebral Artery
Interventions: DRUG: Herbal Medicine C-117|DRUG: The Placebo of Herbal Medicine C-117
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Penpulimab (AK105) in the First-line Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Penpulimab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Enteral Nutrition for Severe Acute Pancreatitis
Status: COMPLETED
Conditions: Acute Necrotizing Pancreatitis
Interventions: DIETARY_SUPPLEMENT: early enteral nutrition|DIETARY_SUPPLEMENT: Parenteral nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Irbesartan/Amlodipine High FDC and Co-administration of Irbesartan and Amlodipine High in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Irbesartan/Amlodipine High FDC|DRUG: Irbesartan|DRUG: Amlodipine High
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of LY3361237 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3361237 - SC|DRUG: LY3361237 - IV|DRUG: Placebo - SC|DRUG: Placebo - IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: High-frequency SCS in Treatment of Chronic Limb-Threatening Ischemia
Status: COMPLETED
Conditions: Chronic Limb-Threatening Ischemia
Interventions: PROCEDURE: High-frequency SCS|PROCEDURE: Low-frequency SCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CRx-401 on Glucose Levels in Subjects With Type II Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: bezafibrate + diflunisal|DRUG: bezafibrate + placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Development of a Proactive Health Care Pathway When Initiating Continuous Subcutaneous Apomorphine Infusion in Patients With Parkinson Disease : Impact on Their Autonomy (AUTAP)
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: OTHER: Proactive care pathway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Analysis of Survival Status of KRAS Mutation Advanced Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: KRAS G12C|Non-small Cell Lung Cancer|KRAS G12D|KRAS G12V|KRAS G12R|KRAS G12Y|KRAS G13N
Interventions: DRUG: Chemotherapy.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety, Tolerability and Drug Levels of BMS-986446 in Healthy Participants and Healthy Participants of Japanese Ethnicity
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: BMS-986446|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise and Mediterranean Diet on Body Composition, Disease Activity and Inflammatory Markers in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid|Dietary Modifications|Motor Activity|Body Composition, Beneficial|Physical Activity|Inflammation
Interventions: OTHER: Dynamic exercise and Mediterranean diet|OTHER: Dynamic exercise|OTHER: Mediterranean diet|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ECT With Ketamine Anesthesia vs High Intensity Ketamine With ECT Rescue for Treatment-Resistant Depression
Status: RECRUITING
Conditions: Treatment Resistant Depression|Ketamine
Interventions: DRUG: Ketamine|PROCEDURE: ECT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Cohera TissuGlu in the Management of Wound Drainage Following Abdominoplasty
Status: COMPLETED
Conditions: Abdominoplasty
Interventions: DEVICE: Cohera TissuGlu Surgical Adhesive|PROCEDURE: Control- Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of Oral Antibiotic Treatment on C. Difficile
Status: COMPLETED
Conditions: C. Difficile|Diarrhea|Enterocolitis
Interventions: DRUG: Fidaxomicin|DRUG: Metronidazole|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EVALUATING THE EFFICIENCY OF BREATHING EXERCISES PERFORMED BY POST-COVID TELEMEDICINE: Randomized Controlled Study
Status: COMPLETED
Conditions: Covid19
Interventions: OTHER: Breathing exercise with the phone application|OTHER: Breathing exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized "All-comer" Evaluation of a Permanent Polymer Resolute Integrity Stent Versus a Polymer Free Cre8 Stent
Status: UNKNOWN
Conditions: Stable Angina Pectoris|Acute Coronary Syndrome
Interventions: DEVICE: Cre8 Stent|DEVICE: Resolute Integrity stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of MEDITOXIN in Treatment of Primary Axillary Hyperhidrosis
Status: COMPLETED
Conditions: Hyperhidrosis Primary Focal Axilla
Interventions: DRUG: Meditoxin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of HYpertension: Morning Versus Evening
Status: UNKNOWN
Conditions: Essential Hypertension
Interventions: DRUG: Enalapril/hydrochlorothiazide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Trimetrexate in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Not Previously Treated for PCP
Status: COMPLETED
Conditions: Pneumonia, Pneumocystis Carinii|HIV Infections
Interventions: DRUG: Trimetrexate glucuronate|DRUG: Leucovorin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Atropine and Glycopyrrolate to Reduce Hyper Salivation With Ketamine Sedation
Status: COMPLETED
Conditions: Sialorrhea
Interventions: DRUG: Atropine (0.01mg/kg)|DRUG: Glycopyrrolate (0.01mg/kg)|DRUG: Normal saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of ONTAK® to Treat Cutaneous T-Cell Lymphoma (CTCL)
Status: COMPLETED
Conditions: Lymphoma, T-Cell, Cutaneous
Interventions: DRUG: ONTAK (denileukin difitox, DAB389IL-2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quality of Life in Allergic Rhinoconjunctivitis Patients Treated With Dialyzable Leukocyte Extracts
Status: COMPLETED
Conditions: Allergic Rhinoconjunctivitis
Interventions: BIOLOGICAL: DLE|OTHER: Second generation anti histamines + Nasal corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2a Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases
Status: NOT_YET_RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Inebilizumab|DRUG: Blinatumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Explore the Effect of Gynostemma Pentaphyllum on Patients With Metabolic Syndrome
Status: UNKNOWN
Conditions: Metabolic Syndrome
Interventions: DRUG: Gynostemma|OTHER: Spinach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of SRF617 in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumor
Interventions: DRUG: SRF617|DRUG: Gemcitabine|DRUG: Albumin-Bound Paclitaxel|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of Denosumab in the Treatment of Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: placebo|DRUG: denosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of BGB-A3055, Alone and in Combination With Tislelizumab in Participants With Selected Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Metastatic Solid Tumor|Solid Tumor
Interventions: DRUG: BGB-A3055|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Isatuximab, Bendamustine, and Prednisone in Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: Isatuximab|DRUG: Bendamustine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Survival Rate of Glass Ionomer Cement, Glass Carbomer Cement and Compomer in Occlusal and Proximal ART Restorations
Status: COMPLETED
Conditions: Caries Involving Multiple Surfaces of Tooth|Dental Caries on Chewing Surface of Tooth|Dental Caries Extending Into Dentine
Interventions: PROCEDURE: GIC Restorations|PROCEDURE: Carbomer Restorations|PROCEDURE: Compomer Restorations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intrauterine Administration of Autologous PBMC Modulated With IFNt on IVF Outcome
Status: RECRUITING
Conditions: Infertility, Female|IVF
Interventions: BIOLOGICAL: PBMC immunomodulated with IFNt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First-in-human Study Looking at the Safety of ZP8396 and How it Works in the Body of Healthy Trial Participants
Status: COMPLETED
Conditions: Overweight|Healthy Volunteers
Interventions: DRUG: ZP8396|DRUG: Placebo (ZP8396)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Heterogeneity and Evolution of hepatoceLlular Carcinoma in Post-transplant HCC Recurrence
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma Recurrent|Liver Transplant; Complications
Interventions: PROCEDURE: liver transplant|DIAGNOSTIC_TEST: ctDNA|DIAGNOSTIC_TEST: whole exome sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Skeletal Muscle Wasting in SARS-CoV-2
Status: COMPLETED
Conditions: Cachexia|Muscle Loss|Muscle Wasting|Muscle Atrophy|Critical Illness
Interventions: PROCEDURE: Muscle Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Two-month Regimens Using Novel Combinations to Augment Treatment Effectiveness for Drug-sensitive Tuberculosis
Status: COMPLETED
Conditions: Tuberculosis, Pulmonary
Interventions: DRUG: Rifampicin|DRUG: Isoniazid|DRUG: Pyrazinamide|DRUG: Ethambutol|DRUG: Linezolid|DRUG: Clofazimine|DRUG: Rifapentine|DRUG: Levofloxacin|DRUG: Bedaquiline|DRUG: Rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Steovess/Binosto After Denosumab Discontinuation to Prevent Increase in Bone Turnover
Status: COMPLETED
Conditions: Erosive Osteoarthritis
Interventions: DRUG: Alendronate Effervescent Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 1 Study to Assess HM15275 in Healthy and Obese Subjects.
Status: RECRUITING
Conditions: Obesity
Interventions: DRUG: HM15275|DRUG: Placebo of HM15275
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Uncut Roux-en-Y vs Roux-en-Y
Status: UNKNOWN
Conditions: Uncut Roux-en-Y|Roux-en-Y|Gastric Cancer
Interventions: PROCEDURE: Uncut Roux-en-Y reconstruction|PROCEDURE: Roux-en-Y reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin Versus Placebo Injections to Temporalis and Masseter Muscles
Status: COMPLETED
Conditions: Pain, Head|Pain Syndrome|Temporomandibular Disorder|Myofascial Pain Syndrome|Myofascial Pain
Interventions: DRUG: Botulinum toxin type A|DRUG: 0.9% Sodium Chloride Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Three Different Sitting Positions for Performing Combined Spinal-Epidural Anesthesia
Status: COMPLETED
Conditions: Anesthesia; Adverse Effect, Spinal and Epidural|Hip Arthropathy|Knee Arthropathy
Interventions: PROCEDURE: positions of patients for combined spinal-epidural anesthesia|PROCEDURE: Combined spinal epidural anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Apatinib Combined With Docetaxel Monotherapy as Second-line Therapy of Advanced EGFR WT, Non-squamous NSCLC
Status: UNKNOWN
Conditions: Nonsquamous Nonsmall Cell Neoplasm of Lung
Interventions: DRUG: Apatinib Combined With Docetaxel
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ponatinib for Patients Whose Advanced Solid Tumor Cancer Has Activating Mutations Involving the Following Genes: FGFR1, FGFR2, FGFR3, FGFR4, RET, KIT.
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Neoplasm
Interventions: DRUG: ponatinib hydrochloride|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of NWT-03 on Blood Pressure - Part 1
Status: COMPLETED
Conditions: Blood Pressure
Interventions: DIETARY_SUPPLEMENT: NWT-03, an egg-white protein hydrolysate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION