pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Efficacy and Safety of Liangxue Ointment in the Treatment of Hand-foot Syndrome Caused by VEGFR-TKI Drugs
Status: RECRUITING
Conditions: Hand-Foot Syndrome
Interventions: DRUG: Liangxue ointment（Traditional Chinese Ointment）|DRUG: Urea cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blood Glucose and Insulin Responses to Snack Food Products
Status: WITHDRAWN
Conditions: Study Focus 1:Glycaemic Index|Study Focus 2:Glycaemic Response|Study Focus 3:Insulinemic Response
Interventions: OTHER: Dietary Intervention|OTHER: Dietary Intervention|OTHER: Dietary Intervention|OTHER: Dietary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intravitreal Topotecan in the Repair of Rhegmatogenous Retinal Detachment With Proliferative Vitreoretinopathy
Status: RECRUITING
Conditions: Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment
Interventions: DRUG: Intravitreal topotecan|PROCEDURE: Pars plana vitrectomy with or without scleral buckle
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Clinical Trial Examining the Effects on Osteoarthritic Knee Pain of CGS-200-1, CGS-200-5 and Vehicle Control
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Pain
Interventions: DRUG: CGS-200-1|DRUG: CGS-200-5|DRUG: CGS-200 Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Olaparib in Combination With Either Durvalumab, Selumetinib, or Capivasertib or Ceralasertib Alone in Treating Patients With Metastatic Triple Negative Breast Cancer
Status: RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Triple-Negative Breast Carcinoma
Interventions: PROCEDURE: Biopsy|DRUG: Capivasertib|DRUG: Ceralasertib|BIOLOGICAL: Durvalumab|DRUG: Olaparib|OTHER: Quality-of-Life Assessment|DRUG: Selumetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Hypofractionated Dose Escalated VMAT to Conventional CCRT in Locally Advanced Head and Neck Cancer
Status: UNKNOWN
Conditions: Locally Advanced Head and Neck Cancer
Interventions: RADIATION: Hypofractionated dose escalated VMAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Comfilcon A and Senofilcon A Lenses
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Senofilcon A; Comfilcon A|DEVICE: Comfilcon A; Senofilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Efficiency of Home-Based Pulmonary Rehabilitation in Adults With Asthma
Status: COMPLETED
Conditions: Pulmonary Rehabilitation|Asthma|Home-based Pulmonary Rehabilitation
Interventions: OTHER: Home-based Pulmonary Rehabilitation|OTHER: Education and Recommendations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peer Groups to Improve Infant Feeding Practices and Child Growth in Post-emergency Settlements in Uganda
Status: COMPLETED
Conditions: Infant Malnutrition
Interventions: BEHAVIORAL: Peer-led integrated nutrition education intervention delivered through Care Groups
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: GM-CSF Before Surgery in Treating Patients With Localized Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: sargramostim|OTHER: immunohistochemistry staining method|OTHER: immunological diagnostic method|OTHER: laboratory biomarker analysis|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digitalized Surveillance Management for Liver Cancer Risk Population in Improving Eearly Diagnosis Efficancy in Chinese Population (dSEARCH)
Status: RECRUITING
Conditions: Carcinoma, Hepatocellular|Hepatitis C, Chronic|Hepatitis B, Chronic|Cirrhosis, Liver|Non-Alcoholic Fatty Liver Disease
Interventions: BEHAVIORAL: Liver cancer surveillance every 3 months|BEHAVIORAL: Liver cancer surveillance every 6 months|BEHAVIORAL: Liver cancer surveillance annually
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Endoscopic Strip Craniectomy for Treatment of Sagittal Craniosynostosis
Status: RECRUITING
Conditions: Craniosynostosis, Sagittal
Interventions: PROCEDURE: Endoscopic strip craniectomy (with lateral osteotomies) with post-operative helmet therapy|PROCEDURE: Endoscopic strip craniectomy (without lateral osteotomies) with post-operative helmet therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pigtail Catheter: a Less Invasive Option for Pleural Drainage of Recurrent Hepatic Hydrothorax
Status: UNKNOWN
Conditions: Pleural Effusion
Interventions: DEVICE: Pigtail catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xeloxiri as First-line Treatment in Patients With Advanced Unresectable Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma
Interventions: DRUG: Capecitabine|DRUG: Oxaliplatin|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: University of North Carolina (UNC) Barrett's Esophagus and Esophageal Cancer Biorepository
Status: ENROLLING_BY_INVITATION
Conditions: Barrett's Esophagus|Esophageal Cancer|Intramucosal Adenocarcinoma
Interventions: OTHER: Specimen Collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tissue Sparing Therapy of Female Precancerous Genital Lesions With VITOM
Status: UNKNOWN
Conditions: Cervical Preinvasive Disease
Interventions: DEVICE: Vitom|DEVICE: Colposcopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I-II Study of Carboplatin, Vinorelbine and Capecitabine in Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast|Cancer
Interventions: DRUG: Carboplatin|DEVICE: Capecitabine|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NordicTrip, a Translational Study of Preoperative Chemotherapy in TNBC
Status: RECRUITING
Conditions: Breast Cancer|Triple Negative Breast Neoplasms
Interventions: DRUG: epirubicin, cyclophosphamide, paclitaxel, carboplatin, pembrolizumab|DRUG: epirubicin, cyclophosphamide, capecitabine, paclitaxel, carboplatin, pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-Dose Ribavirin and Peginterferon to Treat Chronic Hepatitis C Genotype 1
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Peginterferon|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of 23-valent Pneumococcal Polysaccharide Vaccine in Healthy Children, Adults and Elderly
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: investigational 23-valent PPV|BIOLOGICAL: control 23-valent PPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Gliatamin (Chonline Alphoscerate) on Depressive Mood in Type 2 Diabetes Patients
Status: UNKNOWN
Conditions: Type2 Diabetes With Depressive Mood
Interventions: DRUG: Chonline Alphoscerate|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Effects of Blow Bottle Device and Postural Drainage in Moderate to Severe Elderly COPD Patients
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: blow bottle technique|OTHER: percussion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Immunoglobulin for PANDAS
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder|Children|Anxiety Disorder|Autoimmune Disease|PANDAS
Interventions: DRUG: Gamunex Intravenous Immunoglobulin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Cell-Free DNA Liquid Biopsy in Screening High-Risk Patients for Lung Cancer
Status: RECRUITING
Conditions: Lung Carcinoma
Interventions: PROCEDURE: Liquid Biopsy|PROCEDURE: Low Dose Computed Tomography of the Chest|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Tivanisiran for Dry Eye in Subjects With Sjögren's Syndrome
Status: COMPLETED
Conditions: Dry Eye Disease|Sjögren Syndrome
Interventions: DRUG: Tivanisiran sodium ophthalmic solution|DRUG: Vehicle ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Addressing Systemic Health Disparities in Early Identification and Treatment of Autism Spectrum Disorder (ASD): ABCD Project
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Parent Preschool Engagement intervention|BEHAVIORAL: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Intraocular Pressure Measurements Between Reichert Tono-Vera Tonometer and Goldmann Tonometry
Status: COMPLETED
Conditions: Intraocular Pressure|Glaucoma
Interventions: DEVICE: IOP with Goldmann Applanation Tonometer|DEVICE: IOP with comparator ORA G3 and ic100 tonometers|DEVICE: IOP with Tono-Vera Tonometer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evidence-based Intervention to Improve Walking Engagement in El Paso, Texas
Status: RECRUITING
Conditions: Activity Trackers|Physical Activity
Interventions: BEHAVIORAL: 50K4LIfe|BEHAVIORAL: SMS Text Messaging|BEHAVIORAL: Individual|BEHAVIORAL: School
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical High and Genomic Low Hormone Receptor-positive Early Breast Cancer Patients With or Without Adjuvant Chemotherapy
Status: RECRUITING
Conditions: Early Hormone Receptor-positive Breast Cancer
Interventions: DRUG: Chemotherapy Drugs, Cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability and Pharmacokinetics Study of JNJ-54861911 in Healthy Japanese Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-54861911 (25 mg)|DRUG: JNJ-54861911 (50 mg)|DRUG: JNJ-54861911 (100 mg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Proximal Femoral Nail Antirotation With Cement Augmentation in Osteoporotic Femoral Neck Fractures
Status: UNKNOWN
Conditions: Proximal Femur Fracture
Interventions: DEVICE: Proximal Femoral Nail Antirotation(PFNA) with cement augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: Topical r-Hirudin ( Thrombexx ) Efficacy in Treatment of Haematomas
Status: UNKNOWN
Conditions: r-Hirudin (Thrombexx) Efficacy in Treatment of Haematomas
Interventions: DRUG: active product ( Thrombexx) assigned to arm 1|OTHER: Placebo assigned to arm 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Extended Dose Intervals on the Immune Response to Oral Cholera Vaccine
Status: COMPLETED
Conditions: Cholera|Vibrio Cholerae Infection
Interventions: BIOLOGICAL: Oral Cholera Vaccine|BIOLOGICAL: Adjusted Dose Oral Cholera Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Follow-up of Osteo-articular Biomarkers After Spa Therapy in a Population With Knee Osteoarthritis and Their Correlation With the Clinical Evolution
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: Blood collection arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Lifestyle-Related Health Outcomes in Prediabetes and Diabetes
Status: COMPLETED
Conditions: Obesity|Prediabetic State|Type 2 Diabetes
Interventions: BEHAVIORAL: Health Education and Coaching Strategy|BEHAVIORAL: Dietary consult
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Value of Intense Phenotyping in Heart Failure With Preserved Ejection Fraction
Status: RECRUITING
Conditions: Heart Failure, Diastolic
Interventions: DIAGNOSTIC_TEST: Echocardiography|DIAGNOSTIC_TEST: 24 hour Holter monitoring|DIAGNOSTIC_TEST: Cardiac Magnetic Resonance Imaging|DIAGNOSTIC_TEST: 99mTc-HDP scan|DIAGNOSTIC_TEST: ECG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open-Label Safety Study of AXS-05 in Subjects With TRD (EVOLVE)
Status: COMPLETED
Conditions: Treatment Resistant Depression|Major Depressive Disorder
Interventions: DRUG: AXS-05 (dextromethorphan-bupropion)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bleeding in Laser Haemorrhoidoplasty
Status: COMPLETED
Conditions: Hemorrhoids
Interventions: PROCEDURE: Haemorrhoidal Artery Ligation|PROCEDURE: Laser Haemorrhoidoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Minor Salivary Gland Transplantation for Cicatrizing Conjunctivitis
Status: UNKNOWN
Conditions: Cicatrizing Conjunctivitis|Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum|Sjogren Syndrome|Mucous Membrane Pemphigoid|Chronic Graft Versus Host Disease|Chemical Burn to Eye
Interventions: PROCEDURE: minor salivary gland transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double Blind Randomized Study Into the Efficacy of Codeine Phosphate Analgesia After Cleft Palate Repair in Infants
Status: COMPLETED
Conditions: Cleft Palate Repair
Interventions: DRUG: Codeine Phosphate Analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: Does Exercise and Heat Increase the Lightsensibility in Patients With Erythropoietic Protoporphyria
Status: UNKNOWN
Conditions: Erythropoietic Protoporphyria
Interventions: BEHAVIORAL: exercise|BEHAVIORAL: heat|PROCEDURE: red light illumination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study to Evaluate Different Combination Treatment Regimens for Visceral Leishmaniasis
Status: COMPLETED
Conditions: Visceral Leishmaniasis
Interventions: DRUG: Amphotericin B Deoxycholate|DRUG: Ambisome + Miltefosine|DRUG: Ambisome and Paromomycin|DRUG: Miltefosine and Paromomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Advancing Research and Clinical Practice Through Close Collaboration (ARCC): A Pilot Test of an Intervention to Improve Evidence-Based Care and Patient Outcomes
Status: COMPLETED
Conditions: Evidence-Based Medicine|Physician-Nurse Relations
Interventions: BEHAVIORAL: ARCC standard information|BEHAVIORAL: ARCC enhanced|BEHAVIORAL: Placebo
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the Intracorporeal Versus Extracorporeal Anastomosis in Right Hemicolectomy: HEMI-D-TREND-study
Status: COMPLETED
Conditions: Colon Cancer
Interventions: PROCEDURE: Laparoscopic right hemicolectomy with intracorporeal anastomosis.|PROCEDURE: Laparoscopic right hemicolectomy with extracorporeal anastomosis.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Naldemedine in Participants Undergoing Surgeries That Include a Bowel Resection or Bowel Transection
Status: TERMINATED
Conditions: Postoperative Gastrointestinal Dysfunction
Interventions: DRUG: Naldemedine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Menevit Study: Menevit Anti-Oxidant Therapy for the Treatment of Male Infertility
Status: COMPLETED
Conditions: Infertility, Male|Oxidative Stress
Interventions: DRUG: Menevit anti-oxidant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Trial to Compare Urinary Continence Recovery After Robotic Radical Prostatectomy With or Without Rhabdosphincter Reconstruction.
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: PROCEDURE: Radical prostatectomy with posterior rhabdosphincter reconstruction|PROCEDURE: Radical prostatectomy without posterior rhabdosphincter reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SGN-00101 Immunotherapy in Treating Patients With Grade III Cervical Intraepithelial Neoplasia
Status: COMPLETED
Conditions: Cervical Cancer|Precancerous Condition
Interventions: BIOLOGICAL: HspE7
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Renal Function Optimization With Mycophenolate Mofetil (MMF) Immunosuppressor Regimes (ALHAMBRA)
Status: UNKNOWN
Conditions: Kidney Diseases|Graft Rejection
Interventions: DRUG: Tacrolimus|DRUG: Rapamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CIPN-prevention Trial Evaluating the Efficacy of Hand-cooling and Hand-compression
Status: COMPLETED
Conditions: Chemotherapy-induced Peripheral Neuropathy|Onychodystrophy
Interventions: DEVICE: Limb hypothermia|DEVICE: Limb compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety and Efficacy of Switching From Zoladex® Monthly or Quarterly, to Eligard® Semiannual.
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Leuprorelin Acetate (Eligard® 45 mg).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases
Status: RECRUITING
Conditions: Alpha-Thalassemia|Beta-Thalassemia|Amyloidosis|Amyotrophic Lateral Sclerosis|Creutzfeld-Jakob Disease|Cystic Fibrosis|Duchenne Muscular Dystrophy|Early-Onset Alzheimer Disease|Ehlers-Danlos Syndrome|Huntington Disease|Gaucher Disease|GM1 Gangliosidosis|Myasthenia Gravis|Pompe Disease|Sickle Cell Disease|Transthyretin Amyloid Cardiomyopathy|Rare Diseases
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Observational Study of Efficacy and Safety of Modern Insulin in Diabetes Patients Switched From Anti-diabetic Treatment
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir|DRUG: biphasic insulin aspart 30|DRUG: insulin aspart
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Effect of Hepatic Impairment on Safinamide Pharmacokinetics
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: safinamide|DRUG: safinamide|DRUG: safinamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dose-Reduced Docetaxel With Cyclophosphamide for the Treatment of Vulnerable Older Women With Stage I-III HER2 Negative Breast Cancer, the DOROTHY Trial
Status: RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|HER2-Negative Breast Carcinoma
Interventions: DRUG: Cyclophosphamide|DRUG: Docetaxel|OTHER: Medical Chart Review|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Avelumab in Chemo-resistant Gestational Trophoblastic Neoplasias
Status: COMPLETED
Conditions: Gestational Trophoblastic Neoplasias (GTN)
Interventions: DRUG: Avelumab administration at 10mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of Pexidartinib for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS)
Status: COMPLETED
Conditions: Pigmented Villonodular Synovitis|Giant Cell Tumors of the Tendon Sheath|Tenosynovial Giant Cell Tumor
Interventions: DRUG: Pexidartinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Personalizing Enzalutamide Therapy by Understanding the Relation Between Tumor mRNAs, miRNAs and Treatment Response
Status: COMPLETED
Conditions: Metastatic Castration Resistant Prostate Cancer
Interventions: DRUG: Enzalutamide, 160mg, 40 mg soft capsules, once daily
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Equivalence of Generic Ingenol Mebutate Gel 0.05% and Picato Gel 0.05% in Subjects With Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Ingenol Mebutate (Picato®)|DRUG: Generic Ingenol Mebutate|DRUG: Vehicle Foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Association of ALL and ACL Reconstruction Versus Isolated ACL Reconstruction in High-risk Population: a RCT.
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Rupture|Ligament Knee Injury
Interventions: PROCEDURE: Isolated anatomic ACL reconstruction|PROCEDURE: Combined Anterior Cruciate Ligament and Anterolateral Ligament reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating ClariVein With a Sclerosing Agent for the Treatment of Venous Insufficiency
Status: TERMINATED
Conditions: Venous Insufficiency
Interventions: DEVICE: ClariVein RES|DRUG: Sodium Tetradecyl Sulfate 1% Injection|DRUG: Sodium Tetradecyl Sulfate 3% Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating Treatment With Dupilumab in Patients With Allergic Bronchopulmonary Aspergillosis (ABPA) (LIBERTY ABPA AIRED)
Status: COMPLETED
Conditions: Allergic Bronchopulmonary Aspergillosis
Interventions: DRUG: dupilumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Epstein-Barr Virus Antibody and Epstein-Barr Virus DNA for Nasopharyngeal Carcinoma Screening
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DIAGNOSTIC_TEST: EBV antibodies test|DIAGNOSTIC_TEST: EBV DNA test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioavailability Study Comparing Two New Nilotinib Tablet Formulations to an Established Nilotinib Capsule Formulation in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness Feasibility Trial for Insomnia Among Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer Female|Insomnia
Interventions: BEHAVIORAL: Mindfulness-Based Therapy|BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhanced vs. Routine Follow-Up After Total Gastrectomy for Advanced Gastric Cancer: A Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer|Total Gastrectomy|Postoperative Care|Quality of Life|Follow-up
Interventions: OTHER: Enhanced Follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Intravaginal Tamoxifen in PostMenopausal Women With VVA
Status: COMPLETED
Conditions: Vulvar Atrophy
Interventions: DRUG: Tamoxifen|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cumulus Cell Mitochondrial Activity as a Non-invasive Marker of Embryo Quality (FLIM)
Status: RECRUITING
Conditions: IVF/ICSI|Frozen Embryo Transfer|Cumulus Cell|Fluorescence Lifetime Imaging Microscopy
Interventions: GENETIC: FLIM parameters
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: High Dose I-131 Metaiodobenzylguanidine(MIBG) for Metastatic Neuroendocrine Tumors
Status: COMPLETED
Conditions: Neuroendocrine Tumors|Metastases, Neoplasm
Interventions: DRUG: I-131 Metaiodobenzylguanidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega-3 for Depression and Other Cardiac Risk Factors - 2
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Omega-3 supplement|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Protein Supplementation and Exercise Strategy to Promote Muscle Protein Anabolism in Frail Elderly People
Status: COMPLETED
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Protein drink|OTHER: Resistance exercise training|DIETARY_SUPPLEMENT: Placebo drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase Ib Trial of Two Virosome Formulated Malaria Vaccine Components (PEV 301, PEV 302) in Tanzania
Status: COMPLETED
Conditions: Falciparum Malaria
Interventions: BIOLOGICAL: PEV 301& 302 in virosomes|BIOLOGICAL: Inflexal V (active comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Contact Lens and Myopia Control in Optometry School Students
Status: WITHDRAWN
Conditions: Myopia, Progressive
Interventions: DEVICE: Proclear Single Vision Contact Lenses manufactured by CooperVision|DEVICE: Proclear Multifocal Contact Lenses manufactured by CooperVision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Dexmedetomidine in Erector Spinae Block in Postoperative Analgesia
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: erector spinae block with bupivacaine|PROCEDURE: erector spinae block with bupivacaine + dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rotavirus Vaccine Produced by Butantan Institute
Status: COMPLETED
Conditions: Rotavirus Infections
Interventions: BIOLOGICAL: rotavirus vaccine|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Low-Dose Human Growth Hormone Therapy in HIV Infected Patients
Status: COMPLETED
Conditions: HIV Infections|Lipodystrophy
Interventions: DRUG: Placebo|DRUG: Genotropin (human recombinant Growth hormone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Klaribact (Clarithromycin) 500 mg, Film Coated Tablet
Status: COMPLETED
Conditions: Healthy Volunteers|Bioequivalence Study
Interventions: DRUG: Klaribact 500 mg Clarithromycin Tablet|DRUG: Klaricid 500 mg Clarithromycin Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Role of Pregabalin in Treatment of Post-Op Pain in Fracture Patients
Status: COMPLETED
Conditions: Post-operative Pain
Interventions: DRUG: Placebo|DRUG: Pregabalin|DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate Fecobionics in Fecal Incontinence (FI) (NORMAL and ABNORMAL-FI)
Status: RECRUITING
Conditions: Normal Subjects|Fecal Incontinence
Interventions: DEVICE: Fecobionics
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ultrasound and Chemotherapy of Breast Cancer: Relationship Between Early Vascular Changes of the Tumor and Late Tumoral Response
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: Contrast-enhanced Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Musical Engagement of Brain LObes in Alzheimer's Disease Patients StudY
Status: COMPLETED
Conditions: Alzheimer Disease|Dementia|Music Therapy
Interventions: BEHAVIORAL: Preferred Music|BEHAVIORAL: Nature Sounds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Using Thoracic Ultrasound to Detect Interstitial Lung Disease in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis and Associated Conditions|Lung Diseases, Interstitial
Interventions: DIAGNOSTIC_TEST: National guideline treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence Study of Generic Tretinoin 0.1% Microsphere Gel, 0.1% Retin-A Micro® and Placebo
Status: COMPLETED
Conditions: Acne
Interventions: DRUG: Tretinoin microsphere 0.1%|DRUG: Brand Retin-A Micro tretinoin microsphere gel 0.1%|DRUG: placebo microsphere gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dyadic Sleep Intervention for Alzheimer's Disease Patients and Their Caregivers
Status: COMPLETED
Conditions: Sleep|Alzheimer Disease
Interventions: BEHAVIORAL: Behavioral sleep education|BEHAVIORAL: Education only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Open Label, Adaptive, Parallel Group PET Study Using RO7017773 And [11C] RO15-4513
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DRUG: RO7017773|OTHER: [11C] Ro15-4513
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PSMA-PET/CT to Assess the Expression of Specific Membrane Antigen (PSMA) in Patients With Progressive Triple-negative Breast Cancer.
Status: RECRUITING
Conditions: TNBC - Triple-Negative Breast Cancer
Interventions: DIAGNOSTIC_TEST: Ga-PSMA PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: QUILT-3.026: AMG 655 in Combination With AMG 479 in Advanced, Refractory Solid Tumors
Status: TERMINATED
Conditions: Colorectal Cancer|Locally Advanced|Metastatic Cancer|Non-Small Cell Lung Cancer|Ovarian Cancer|Pancreatic Cancer|Sarcoma|Solid Tumors
Interventions: BIOLOGICAL: AMG 479|BIOLOGICAL: AMG 655
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Islet Transplantation Outcomes With Gastrin for Type I Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1
Interventions: BIOLOGICAL: Allogenic Human Islet Cells|DRUG: Gastrin 17
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant mFOLFOXIRI vs. mFOLFOX6 in MRD Positive Stage II-III Colorectal Cancer (AFFORD)
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: mFOLFOXIRI|DRUG: mFOLFOX6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Imaging in the Diagnosis of Parkinsonian Syndromes
Status: TERMINATED
Conditions: Parkinson's Disease|Multiple System Atrophy|Progressive Supranuclear Palsy|Vascular Parkinsonism
Interventions: OTHER: MRI exam of the brain
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Laboratory Test in Predicting Response to Erlotinib in Patients With Relapsed Metastatic or Unresectable Non-Small Cell Lung Cancer That Did Not Respond to Previous Treatment
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: erlotinib hydrochloride|GENETIC: gene expression analysis|GENETIC: protein expression analysis|OTHER: immunoenzyme technique|OTHER: immunologic technique|OTHER: laboratory biomarker analysis|PROCEDURE: needle biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interdental Guided Creeping Technique
Status: NOT_YET_RECRUITING
Conditions: Interdental Papilla Recession
Interventions: PROCEDURE: Interdental guided creeping technique (IGCT) and connective tissue graft (CTG)|PROCEDURE: Interdental guided creeping technique (IGCT) and collagen membrane (CM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Diet and Physical Activity Changes on Body Weight, Biomarkers and Quality of Life in Breast Cancer Survivors
Status: COMPLETED
Conditions: Body Weight Changes|Mammographic Density|Quality of Life
Interventions: BEHAVIORAL: Motivational Interviewing|BEHAVIORAL: Traditional Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A VR Intervention for Prosocial Behavior and Well-being Among Adolescents
Status: NOT_YET_RECRUITING
Conditions: Adolescent
Interventions: BEHAVIORAL: Prosocial VR intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Correlation of Auscultatory Severity of Aortic Stenosis With Trans Thoracic Echocardiography
Status: COMPLETED
Conditions: Aortic Stenosis
Interventions: OTHER: Tranthoracic Echocardiogram|DEVICE: Cardiac Ascultation Recordings with Electronic stethoscope
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impedance Cardiographic (ICG) Assessment of Pregnant Women With Severe Hypertension to Assess Impact of Standard Therapy
Status: COMPLETED
Conditions: Pregnancy; Proteinuria, With Hypertension (Severe Pre-eclampsia)|Delivery; Proteinuria, With Gestational Hypertension (Pre-eclampsia, Severe)|Pregnancy; Hypertension, Gestational Hypertension, With Albuminuria (Severe Pre-eclampsia)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Almonds in Glucose-intolerant Adults (AGAMEMNON)
Status: RECRUITING
Conditions: PreDiabetes|NAFLD
Interventions: DIETARY_SUPPLEMENT: Raw whole almonds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate ALIS (Amikacin Liposome Inhalation Suspension) in Participants With Nontuberculous Mycobacterial Lung Infection Caused by Mycobacterium Avium Complex
Status: RECRUITING
Conditions: Mycobacterium Infections, Nontuberculous
Interventions: DRUG: ALIS|DRUG: Azithromycin|DRUG: Ethambutol|DRUG: ELC (matching placebo for ALIS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Implant Surface Material and Topography on Bone Regeneration.
Status: RECRUITING
Conditions: Dental Implant|Guided Bone Regeneration|Biomarkers|Saliva
Interventions: COMBINATION_PRODUCT: Zirconia surface implant and guided bone regeneration|COMBINATION_PRODUCT: Hydrophilic titanium surface implant and guided bone regeneration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Yi Jin Bang Exercise and Usual Exercise Therapy in Adults With Subacromial Pain Syndrome
Status: COMPLETED
Conditions: Subacromial Pain Syndrome
Interventions: BEHAVIORAL: 10-week home-based Yi Jin Bang exercise program|BEHAVIORAL: 10-week home-based usual exercise therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Vitamin D Supplementation Tailored to Vitamin D Deficiency in Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: calcium and cholecalciferol|DRUG: calcium and cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TCF7L2 Polymorphisms Influence on Glycemic Control in ICU Patients With Organ Failure
Status: COMPLETED
Conditions: Genetic Predisposition to Disease|Hyperglycemia|Intensive Care Unit Syndrome|Multiple Organ Failure
Interventions: GENETIC: genetic analysis|BIOLOGICAL: blood and stools samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of TTPB vs PIFB on Opioid Consumption in Patients After Cardiac Surgery.
Status: RECRUITING
Conditions: Pain|Postoperative
Interventions: PROCEDURE: Transversus thoracic plane block|PROCEDURE: Pecto intercostal fascial block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Proxelan Somministration in Patients With Chronic Prostatitis
Status: UNKNOWN
Conditions: Chronic Prostatitis|Chronic Prostatitis With Chronic Pelvic Pain Syndrome|Premature Ejaculation
Interventions: DRUG: Proxelan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patiromer Trial in CKD Stage IIIB to V
Status: RECRUITING
Conditions: Hyperkalemia
Interventions: DRUG: Veltassa Oral Powder Product|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Probiotics on Excessive Gas Accumulation
Status: COMPLETED
Conditions: Flatulence|Bloating
Interventions: DIETARY_SUPPLEMENT: Probiotic supplement|DIETARY_SUPPLEMENT: Placebo supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of an Evidence-based Electronic Decision Support System on Diabetes Care
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: The EBMeDS system|OTHER: Evidence Linker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Toripalimab or Placebo With Paclitaxel and Cisplatin in Esophageal Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Advanced or Metastatic Esophageal Squamous Cell Cancer Without Previous Systemic Chemotherapy
Interventions: BIOLOGICAL: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Secukinumab Dosage Optimisation in Partial Responders With Moderate to Severe Plaque-type Psoriasis
Status: COMPLETED
Conditions: Moderate to Severe Plaque-type Psoriasis
Interventions: DRUG: Secukinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Self-pressurized Air-Q With Blocker and Air-Q Blocker in Low Risk Female Patients Undergoing Ambulatory Surgery
Status: COMPLETED
Conditions: Ambulatory Surgery
Interventions: DEVICE: Self-pressurized air-Q with blocker|DEVICE: Air-Q ILA blocker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Which Exercises Should Diabetic Patients do?
Status: COMPLETED
Conditions: Type2 Diabetes|Physical Activity
Interventions: OTHER: Custom Designed Exercises|OTHER: Plates Exercises|OTHER: Calisthenics Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Comparative Effectiveness of Prucalopride and Lubiprostone in Constipation Predominant Irritable Bowel Syndrome
Status: UNKNOWN
Conditions: Patient Satisfaction
Interventions: DRUG: Prucalopride 2mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Packing of Perianal Abscess Cavities
Status: COMPLETED
Conditions: Perianal Abscess|Perianal Infections|Peri Rectal Abscess|Abscess; Anus|Abscess Anorectal
Interventions: OTHER: External dressing|OTHER: Packing of perianal abscess cavity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Diclofenac Capsules to Treat Osteoarthritis Pain
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Diclofenac|DRUG: Diclofenac|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: All-Trans Retinoic Acid (ATRA) and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Metastatic Lung Non-Small Cell Carcinoma|Recurrent Lung Non-Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: BIOLOGICAL: Atezolizumab|DRUG: Tretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Cilostazol Compared to Aspirin on Endothelial Function in Acute Cerebral Ischemia Patients
Status: COMPLETED
Conditions: Ischemic Stroke|Endothelial Dysfunction
Interventions: DRUG: Cilostazol 100mg|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT