pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pembrolizumab and Carboplatin in Treating Patients With Relapsed or Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma
Interventions: DRUG: Carboplatin|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: pBFS-guided Multi-target cTBS for Aphasia After Stroke
Status: RECRUITING
Conditions: Stroke|Aphasia
Interventions: DEVICE: active continuous Theta Burst Stimulation|DEVICE: sham continuous Theta Burst Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of a Low Glycemic Load Diet on Dysglycemia and Body Composition in Adults With Cystic Fibrosis-Related Diabetes
Status: RECRUITING
Conditions: Cystic Fibrosis|Cystic Fibrosis-related Diabetes|Cystic Fibrosis With Intestinal Manifestations
Interventions: BEHAVIORAL: Low Glycemic Load Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Bempegaldesleukin (NKTR-214: BEMPEG) in Combination With Nivolumab Compared With the Investigator's Choice of a Tyrosine Kinase Inhibitor (TKI) Therapy (Either Sunitinib or Cabozantinib Monotherapy) for Advanced Metastatic Renal Cell Carcinoma (RCC)
Status: TERMINATED
Conditions: Renal Cell Carcinoma|Metastatic Renal Cell Carcinoma
Interventions: BIOLOGICAL: bempegaldesleukin|DRUG: sunitinib|BIOLOGICAL: nivolumab|DRUG: cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate vs. Deferred Empirical Antifungal Treatment With Voriconazole In Neutropenic Patients
Status: COMPLETED
Conditions: Possible Fungal Infection
Interventions: DRUG: voriconazole (Vfend)|DRUG: voriconazole (Vfend)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Futibatinib in Patients With Specific FGFR Aberrations
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced or Metastatic Solid Tumor|Advanced or Metastatic Gastric or Gastroesophageal Cancer|Myeloid or Lymphoid Neoplasms (MLN)
Interventions: DRUG: Futibatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraperitoneal Bupivicaine Infusion Using the On-Q Pain Pump After Laparoscopic Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: On-Q Pain Pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-articular Versus Intravenous Dexmedetomidine in Arthroscopic Knee Surgeries Under Local Anesthesia
Status: COMPLETED
Conditions: Knee Arthroscopy
Interventions: DRUG: Intra-articular dexmedetomidine|DRUG: Intravenous dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ongoing Registry of Treatment of Venous Thromboembolism
Status: RECRUITING
Conditions: Deep Vein Thrombosis|Thromboses, Venous|Thrombosis Embolism|Postthrombotic Syndrome|Pulmonary Embolism
Interventions: DRUG: Anticoagulants|PROCEDURE: Open surgery|PROCEDURE: Thrombolysis|PROCEDURE: Venous stenting
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Endocrine Changes and Their Correction in Heart and Lung Transplant Recipients and Donors
Status: UNKNOWN
Conditions: Endocrine System Diseases|Thyroid Diseases|Cortisol Deficiency|Diabetes Insipidus|End-stage Heart Failure|End Stage Lung Disease
Interventions: PROCEDURE: Blood test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chemical and Mechanical Angioplasty for Vasospasm (SAVEBRAIN)
Status: COMPLETED
Conditions: Aneurysmal Subarachnoid Hemorrhage|Vasospasm, Intracranial|Stenosis|Ruptured Cerebral Aneurysm|Arteriovenous Malformations, Cerebral|Arteriovenous Fistula
Interventions: PROCEDURE: Chemical and Mechanical Angioplasty for Refractory Intracranial Arterial Vasospastic Stenosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Cognitive Behavioral Stress Intervention for Women Who Smoke
Status: COMPLETED
Conditions: Smoking, Cigarette|Smoking Cessation|Stress|Stress, Emotional|Stress Reaction
Interventions: BEHAVIORAL: heart rate variability biofeedback and cognitive reappraisal|BEHAVIORAL: control tasks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Application of LED Photobiomodulation in the Treatment of Chronic Low Back Pain
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: RADIATION: LED Photobiomodulation|OTHER: Placebo LED Photobiomodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic, Physical Responses To Exercise In Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type2 Diabetes Mellitus|Exercise
Interventions: OTHER: exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Optical Coherence Tomography (OCT) Findings and Coronary Bifurcation Lesions
Status: COMPLETED
Conditions: Coronary Bifurcation Lesions
Interventions: PROCEDURE: percutaneous coronary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Comparative Study Between Arm Intravenous Regional Anesthesia Versus Forearm Intravenous Regional Anesthesia in Patients Undergoing Hand and Wrist Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Intravenous Anesthetic Agent Overdose|Hand Injury Wrist
Interventions: PROCEDURE: Arm intravenous regional anesthesia|PROCEDURE: Forearm IVRA block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Military to Civilian: Trial of an Intervention to Promote Postdeployment Reintegration
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Expressive Writing|BEHAVIORAL: Control Writing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Inducing Graft Tolerance in HLA Haplotype Matched Related and 3 Ag Matched Unrelated Living Donor Kidney Transplantation
Status: UNKNOWN
Conditions: Immune Tolerance
Interventions: PROCEDURE: Immune tolerance after kidney transplant|DRUG: Donor blood stem cells and T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Endoscope-assisted, Minimally-invasive Cortical Access System for Chronic Subdural Evacuation
Status: TERMINATED
Conditions: Chronic Subdural Hematoma
Interventions: DEVICE: Minimally Invasive Cortical Access System (MICAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: VertiGO! - Get up and GO! With the Vestibular Implant
Status: ACTIVE_NOT_RECRUITING
Conditions: Bilateral Vestibular Loss
Interventions: DEVICE: Cochlear Vestibular Implant (CVI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Emricasan, a Caspase Inhibitor, for Treatment of Subjects With Decompensated NASH Cirrhosis
Status: UNKNOWN
Conditions: Decompensated Cirrhosis
Interventions: DRUG: Emricasan (25 mg)|DRUG: Emricasan (5 mg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Manuel Therapy and BETY in Patients With Temporomandibular Dysfunction Related Headache
Status: RECRUITING
Conditions: Temporomandibular Disorders|Headache
Interventions: PROCEDURE: Patient education and preventive exercise|PROCEDURE: Patient education, preventive exercise combined with Manual Therapy protocol|PROCEDURE: Patient education, preventive exercise combined with BETY approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC
Status: COMPLETED
Conditions: Atherosclerosis|Cardiovascular Diseases|Heart Diseases|Coronary Disease|Carotid Artery Diseases|Peripheral Vascular Diseases|Cerebral Arteriosclerosis|Cerebrovascular Accident
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Difluprednate Pediatric Study for the Treatment of Inflammation Post-Cataract Surgery
Status: COMPLETED
Conditions: Cataracts|Inflammation
Interventions: DRUG: Difluprednate ophthalmic emulsion, 0.05%|DRUG: Prednisolone acetate ophthalmic suspension, 1.0%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Analyzing Pulsed Reduced Dose Radiotherapy in Upfront Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma
Interventions: DEVICE: Radiation|DRUG: Concurrent Chemotherapy (Temozolomide)|DRUG: Adjuvant Chemotherapy (Temozolomide)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Single Dose MK-3614 (MK-3614-001)(COMPLETED)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: MK-3614|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Visualize the Ureters With Nizaracianine Triflutate in Adults Undergoing Abdominopelvic Surgery
Status: RECRUITING
Conditions: Injury of Ureter During Surgery (Disorder)
Interventions: DRUG: Nizaracianine Triflutate|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Rehabilitation of Women Following Treatment for Gynaecological Cancer; a Randomized, Controlled Study
Status: UNKNOWN
Conditions: Gynecologic Cancer
Interventions: BEHAVIORAL: Physical training in group|BEHAVIORAL: Educational and counseling in group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: 3 Months Versus 12 Months Dual Antiplatelet Therapy After Drug-eluting Stent Implantation in STEMI
Status: UNKNOWN
Conditions: ST Elevation Myocardial Infarction
Interventions: DRUG: ticagrelor monotherapy|DRUG: Aspirin with P2Y12 receptor inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cilostazol Stroke Prevention Study : A Placebo-controlled Double-blind Trial for Secondary Prevention of Cerebral Infarction.
Status: COMPLETED
Conditions: Cerebral Infarction
Interventions: DRUG: cilostazol|DRUG: placebo of cilostazol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of PRT7732, an Oral SMARCA2 Degrader, in Patients With Advanced or Metastatic Solid Tumors With a SMARCA4 Mutation
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumor|Metastatic Solid Tumor|Non-small Cell Lung Carcinoma|SMARCA4 Mutation
Interventions: DRUG: PRT7732
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Two Part Trial Investigating the Safety of NN9925 in Healthy Male Subjects
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2|Healthy
Interventions: DRUG: NN9925 (oral)|DRUG: NN9925 (i.v.)|DRUG: placebo|DRUG: NN9925 (oral)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Hot-Cold Application to the Bladder After Orthopedic Surgery on Postoperative Urinary Retention
Status: COMPLETED
Conditions: Postoperative Urinary Retention
Interventions: PROCEDURE: application of thermophor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Oxygen as an Acute Treatment in Alternating Hemiplegia of Childhood
Status: NOT_YET_RECRUITING
Conditions: Alternating Hemiplegia of Childhood
Interventions: DRUG: Oxygen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Doxycycline for Central Nervous System Tuberculosis
Status: NOT_YET_RECRUITING
Conditions: Tuberculosis, Meningeal|Tuberculosis; Meningitis (Etiology)|Tuberculosis, Central Nervous System|Tuberculosis; Meningoencephalitis (Etiology)
Interventions: DRUG: Doxycycline|DRUG: Placebo|DRUG: Anti Tuberculosis Drug|DRUG: Adjunctive corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Confirmatory Study in Erythropoietic Protoporphyria (EPP)
Status: COMPLETED
Conditions: Erythropoietic Protoporphyria
Interventions: DRUG: Afamelanotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neuroleptic and Huntington Disease Comparison of : Olanzapine, la Tetrabenazine and Tiapride
Status: COMPLETED
Conditions: Huntington Disease
Interventions: DRUG: Olanzapine|DRUG: Xenazine|DRUG: Tiapridal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Laminate Veneers With Coronal Post Versus Post and Core Foundation Restoration With Single Crown for Restoration of Endodontically Treated Anterior Teeth (Randomized Controlled Trial) "In-vivo Study"
Status: UNKNOWN
Conditions: Teeth, Endodontically-Treated|Anterior Teeth
Interventions: PROCEDURE: laminate veneer with coronal post|PROCEDURE: post,core and crown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ALXN2050 in Healthy Adult Participants of Japanese Descent
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ALXN2050|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Multicenter Trial of Rofecoxib and Naproxen in Alzheimer's Disease (NSAID Study)
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Rofecoxib|DRUG: Naproxen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability and Pharmacokinetics Study of Sirukumab in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Sirukumab (IV infusion)|DRUG: Sirukumab (SC injection with PFS-U)|DRUG: Sirukumab (SC injection with PFS-AI)|DRUG: Sirukumab (SC injection with PFS-U)|DRUG: Sirukumab (SC injection with PFS-AI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Home-based Arm and Hand Exercise to Improve Upper Limb Function After Traumatic Brain Injury
Status: COMPLETED
Conditions: Brain Injuries, Traumatic
Interventions: OTHER: Wrist Alarm|BEHAVIORAL: Home-based Arm and Hand Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety Study of Sulodexide in Filipino Diabetic Patients With Chronic Kidney Disease
Status: UNKNOWN
Conditions: Chronic Kidney Disease
Interventions: DRUG: Sulodexide|DRUG: placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Electrostimulation in Radiocephalic Fistula
Status: UNKNOWN
Conditions: Arteriovenous Fistula
Interventions: DEVICE: Neuromuscular electrostimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Quality of Life of TEP vs Lichtenstein Hernioplasty
Status: UNKNOWN
Conditions: Inguinal Hernia
Interventions: PROCEDURE: Open Lichtenstein Hernioplasty|PROCEDURE: Laparoscopic TEP Hernioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Ascending Dose Study of Safety and Tolerability of STA363 Compared to Placebo in 15 Patients With Chronic Discogenic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: STA363|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MitoQ & Cardiopulmonary Responses During Exercise
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: MitoQ|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Trial to Evaluate the Efficacy of Treatment With Hyperimmune Plasma Obtained From Convalescent Antibodies of COVID-19 Infection
Status: COMPLETED
Conditions: SARS-CoV 2
Interventions: BIOLOGICAL: Hyperimmune plasma|DRUG: Standard of care for SARS-CoV-2 infection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GENESIS: Genetic Biopsy for Prediction of Surveillance Intervals After Endoscopic Resection of Colonic Polyps
Status: COMPLETED
Conditions: Colonic Polyps
Interventions: GENETIC: Polypectomy and NGS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Intrathecal Morphine Administration Using Implantable Pump With Continuous or Programmable Flow
Status: COMPLETED
Conditions: Advanced Cancer|Intractable Pain
Interventions: DEVICE: Implantable pump with continuous flow|DEVICE: Implantable pump with programmable flow.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Best Corrected Visual Acuity (BCVA) in Patients With Neovascular Age-Related Macular Degeneration (AMD) Who Are Administered VEGF Trap-Eye (Intravitreal Aflibercept Injection)
Status: COMPLETED
Conditions: Age - Related Macular Degeneration (AMD)
Interventions: DRUG: Intravitreal Aflibercept Injection (IAI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bringing South African Men Into HIV Counseling and Testing and Care
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: BEHAVIORAL: Men-Centered HIV Testing|BEHAVIORAL: Linkage to Care for HIV+ Men|BEHAVIORAL: Clinic-based HIV Testing|BEHAVIORAL: Clinic Referral for HIV+ Men
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of L-theanine on Motor Cortex Excitability in Healthy Subjects: A Paired-Pulse TMS Study
Status: COMPLETED
Conditions: Cortical Excitability|Psychiatric Disorder
Interventions: DRUG: L-theanine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Psoriatic Arthritis Study of Izokibep
Status: ACTIVE_NOT_RECRUITING
Conditions: Psoriatic Arthritis
Interventions: DRUG: Izokibep|DRUG: Placebo to izokibep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Alemtuzumab (Campath) to Treat T-Large Granular Lymphocyte Leukemia
Status: COMPLETED
Conditions: T-LGL Lymphoproliferative Disorders
Interventions: BIOLOGICAL: Alemtuzumab (Campath)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Uremic Toxins in the Intensive Care Unit (ICU): Patients With Sepsis
Status: WITHDRAWN
Conditions: Renal Failure|Multi Organ Failure
Interventions: PROCEDURE: Dialysis during 4 hours|PROCEDURE: Dialysis during 6 hours|PROCEDURE: Dialysis during 8 hours
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Ca(OH)2 in Apical Periodontitis
Status: COMPLETED
Conditions: Periapical Periodontitis|Polymerase Chain Reaction|Intracanal Medicament|Enterococcus Faecalis Infection
Interventions: OTHER: calciumhydroxide, intracanal medicament|OTHER: chlorhexidine, intracanal medicament
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Application of Hyperspectral Imaging Technique in CTX Treatment of IMN
Status: NOT_YET_RECRUITING
Conditions: Hyperspectral Imaging|Idiopathic Membranous Nephropathy|Cyclophosphamide
Interventions: DEVICE: Microscopic hyperspectral imaging system
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Patient Perception and Clinical Efficacy of a Collagen Matrix for the Treatment of Peri-implantitis
Status: UNKNOWN
Conditions: Peri-Implantitis
Interventions: OTHER: Acellular collagen matrix|OTHER: Autogenous free gingival graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of the Infra-Red Illumination for Facilitation of Video Scope-tracheal Intubation
Status: UNKNOWN
Conditions: Airway Morbidity|Covid19|Trachea
Interventions: DEVICE: Application of Infrared (Active IRD/ IRRIS) device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Serum Metabolic Markers and Early Complications After Allo-HSCT： Cohort Study
Status: NOT_YET_RECRUITING
Conditions: Stem Cell Transplant Complications|Acute Graft Versus Host Disease|Acute Kidney Injury|Major Adverse Cardiac Events
Interventions: OTHER: Serum metabolomics sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prospective Randomized Study of Glucocorticoids in the Impact of the Liver Function and the Prognosis After Hepatectomy of HCC
Status: SUSPENDED
Conditions: Some Studies Shows That the Steroid Can Reduce the Injury of the I/R of the Liver
Interventions: DRUG: Hydrocortisone sodium succinate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Incidence of Deep Vein Thrombosis on Central Venous Catheters in the Post Operative Period of Carcinologic Surgery
Status: UNKNOWN
Conditions: Critically Ill|Central Venous Catheter Thrombosis|PARENTERAL NUTRITION|POST OPERATIVE
Interventions: DIAGNOSTIC_TEST: DOPPLER ULTRASOUND
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the Anxiolytic Effects of Aframomum Seed Extract in Elderly People
Status: COMPLETED
Conditions: Situational Anxiety
Interventions: DIETARY_SUPPLEMENT: Vanizem|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preemptive Ibuprofen Effects on Pain Perception Following Extraction and Bone Graft
Status: NOT_YET_RECRUITING
Conditions: Pain, Post Operative|Quality of Life
Interventions: DRUG: Ibuprofen 600 mg|DRUG: Placebo|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer
Status: RECRUITING
Conditions: Autoimmune Disease|Crohn Disease|Dermatomyositis|Hematopoietic and Lymphoid Cell Neoplasm|Inflammatory Bowel Disease|Malignant Solid Neoplasm|Multiple Sclerosis|Psoriasis|Psoriatic Arthritis|Rheumatoid Arthritis|Sjogren Syndrome|Systemic Lupus Erythematosus|Systemic Scleroderma|Ulcerative Colitis
Interventions: PROCEDURE: Biospecimen Collection|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Acute and Chronic Exercise at the Metabolic Syndrome and Markers of Inflammation in Obese Subjects
Status: UNKNOWN
Conditions: Obesity|Healthy
Interventions: BEHAVIORAL: Exercise-only (EXO-12 weeks of regular supervised exercise without diet restriction)|BEHAVIORAL: Diet-only (DIO-8 weeks of very low energy diet (VLED 600 kcal/d) followed by 4 weeks weight maintenance diet|BEHAVIORAL: Diet+exercise (DEX-8 weeks VLED 800 kcal/d + a four weeks weight maintenance diet combined with regular supervised exercise throughout the 12 weeks).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FODMAP Reintroduction in Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Diarrhea|Irritable Bowel Syndrome With Mixed Bowel Habits
Interventions: OTHER: Dietary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Lithium Plus Optimized Medication in Treating People With Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Lithium Carbonate|DRUG: Optimized Treatment (OPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Music Therapy With Intubated and Sedated Pediatric Patients
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: BEHAVIORAL: Live Music Therapy|BEHAVIORAL: Recorded Music Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acute Cholecystitis: Early Versus Delayed Laparoscopic Cholecystectomy; Randomized Prospective Study
Status: UNKNOWN
Conditions: Acute Cholecystitis
Interventions: PROCEDURE: Early cholecystectomy|PROCEDURE: Delayed cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyperpolarised 13C-Pyruvate MRI Study
Status: UNKNOWN
Conditions: Cancer|Cardiovascular Diseases
Interventions: DIAGNOSTIC_TEST: Hyperpolarised MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial of SHR-1707 Infusion in Patients With Mild Cognitive Impairment Due to Alzheimer's Disease and Mild Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer's Disease (AD)
Interventions: DRUG: SHR-1707 injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Laparoscopic Ovarian Diathermy and Clomiphene Citrate in Women With Anovulatory PCOS
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: PROCEDURE: Laparoscopic ovarian diathermy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Non-inferiority Study to Evaluate the Efficacy, Safety, and Tolerability of Fluticasone Propionate/Salmeterol (FSC) 250/50 Microgram (mcg) Through a Capsule-Based Inhaler and a Multi-Dose Inhaler Administered Twice Daily (BID) in Adults With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: FSC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chemosensitization With Plerixafor Plus G-CSF in Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: G-CSF|DRUG: Plerixafor|DRUG: Mitoxantrone|DRUG: Etoposide|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low EnerGy DiEt iN Adolescents With Obesity and Type 2 Diabetes: The LEGEND Study
Status: NOT_YET_RECRUITING
Conditions: Pediatric Obesity|Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Low-energy diet|OTHER: Qualitive interview - LED participants|OTHER: Qualitive interview - Participants declining LED|OTHER: Qualitive interview - Health Care Professionals (HCPs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peri-Procedural Myocardial Infarction, Platelet Reactivity, Thrombin Generation, and Clot Strength: Differential Effects of Eptifibatide + Bivalirudin Versus Bivalirudin
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Bivalirudin with and without eptifibatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Bioavailability of of 2 New Formulations of UCB0599 in Healthy Participants in Part A and to Test Safety, Tolerability, and Pharamacokinetic (PK) of UCB0599 in Healthy Japanese and Chinese Participants in Part B
Status: COMPLETED
Conditions: Healthy Study Participants
Interventions: DRUG: UCB0599|OTHER: Esomeprazole|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intensive Neurorehabilitation and Stimulation in Chronic Stroke Patients
Status: UNKNOWN
Conditions: Chronic Stroke
Interventions: DEVICE: Ipsilesional stimulation|DEVICE: Contralesional stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-operative Exparel Study Following Rotator Cuff Repair
Status: UNKNOWN
Conditions: Rotator Cuff Tears
Interventions: DRUG: Liposomal bupivacaine|DRUG: Ropivacaine injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study to Evaluate Antimicrobial Effectiveness of ZuraPrep™ (ZX-ZP-0055)
Status: COMPLETED
Conditions: Surgical Site Infection
Interventions: DRUG: ZuraPrep|DRUG: ChloraPrep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: The OPTIMISE Study
Status: NOT_YET_RECRUITING
Conditions: Pseudophakic Bullous Keratopathy|Fuchs' Endothelial Dystrophy|Intraocular Pressure
Interventions: DRUG: Fluorometholone 0.1% Oph Susp|DRUG: Dexamethasone 0.1% ophthalmic suspension|OTHER: Stop steroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation Study to Investigate the Effect of a New Treatment in Patients With Osteoarthritic Pain
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: BEHAVIORAL: Positive behaviour|DRUG: T4P1010 administration|GENETIC: Pharmacogenetic|OTHER: Questionnaires and diary completion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: EFFECT OF FLOW RESTRICTION ON BONE QUALITY WITHIN A MULTICOMPONENT EXERCISE PROGRAM FOR OLDER WOMEN WITH OSTEOPOROSIS.
Status: UNKNOWN
Conditions: Osteoporosis|Osteoporosis, Postmenopausal|Bone Diseases|Exercise
Interventions: OTHER: Multicomponent Exercise with Blood Flow Restriction|OTHER: Multicomponent Exercise without Blood Flow Restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Varenicline on Cognitive Function in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Varenicline(Chantix)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Pomalidomide and Bendamustine With Dexamethasone in Relapsed or Refractory Multiple Myeloma
Status: UNKNOWN
Conditions: Relapsed, Refractory, Multiple Myeloma
Interventions: DRUG: Pomalidomide|DRUG: Bendamustine|DRUG: Dexamethasone|DRUG: Pomalidomide|DRUG: Bendamustine|DRUG: Dexamethasone|DRUG: Pomalidomide|DRUG: Bendamustine|DRUG: Dexamethasone|DRUG: Pomalidomide|DRUG: Bendamustine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Depot Naltrexone Mechanism of Action in Heroin Dependent Patients Using fMRI and SPECT
Status: COMPLETED
Conditions: Opioid-Related Disorders|Heroin Dependence
Interventions: DRUG: Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PIB for Post-operative Analgesia After Laparotomy : Determining the Optimum Dose
Status: RECRUITING
Conditions: Acute Post Operative Pain|Laparotomy|Epidural Analgesia
Interventions: DRUG: Programmed intermittent epidural bolus 5 ml|DRUG: Programmed intermittent epidural bolus 6 ml|DRUG: Programmed intermittent epidural bolus 7 ml|DRUG: Programmed intermittent epidural bolus 8 ml|DRUG: Programmed intermittent epidural bolus 9 ml|DRUG: Programmed intermittent epidural bolus 10 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Lenalidomide (REVLIMID®) to Treat Subjects With Cutaneous Lupus Erythematosus (CLE)
Status: COMPLETED
Conditions: Cutaneous Lupus Erythematosus (CLE)
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving HIV Prevention Among Heterosexual Cisgender Men Seeking STI Services in Malawi
Status: ENROLLING_BY_INVITATION
Conditions: HIV Infection|Sexually Transmitted Infections|Pre-exposure Prophylaxis|Systems Navigation
Interventions: OTHER: PrEP eligibility assessment|DIAGNOSTIC_TEST: Rapid HIV antibody testing prior to provision and/or refill of PrEP|OTHER: PrEP follow-up with a PrEP nurse in accordance with contemporary PrEP guidelines|BEHAVIORAL: Evaluation of barriers and facilitators to ongoing PrEP use|OTHER: Point of contact STI testing to inform counseling regarding ongoing PrEP care engagement|OTHER: Tracing for any missed PrEP visits|OTHER: Offering a PrEP "restart" kit for cisgender men who choose to discontinue PrEP during the follow-up period
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Beverage Powder With Micronutrients and Brahmi Extract on Cognitive Variables in Indian School Children
Status: COMPLETED
Conditions: Cognition
Interventions: DIETARY_SUPPLEMENT: Beverage powder fortified with micronutrients and Bacopa monnieri extract|OTHER: Non fortified isocaloric control (without added micronutrients and Bacopa monnieri extract)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Thulium Beam Coagulation Versus Suture Renorrhaphy for Hemostasis of Tumor Bed in Laparoscopic Partial Nephrectomy
Status: RECRUITING
Conditions: Renal Tumor|Renal Malignant Tumor
Interventions: PROCEDURE: Suture renorrhaphy only for hemostasis of the tumor bed in laparoscopic partial nephrectomy|PROCEDURE: Thulium beam coagulation and suture renorrhaphy for hemostasis of the tumor bed in laparoscopic partial nephrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of a Dynamic Sustained Compression Intramedullary Nail for Tibiotalocalcaneal Arthrodesis
Status: UNKNOWN
Conditions: Ankle Arthritis|Arthritis Foot
Interventions: DEVICE: DynaNail|PROCEDURE: Tibiotalocalcaneal Arthrodesis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intrathecal Morphine for Radical Robot Assisted Prostatectomy (TORNADO)
Status: COMPLETED
Conditions: Catheter Related Complication
Interventions: DRUG: intrathecal infusion|DRUG: Intravenous Infusion|DRUG: Ropivacaine injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of the Buprenorphine Transdermal System (BTDS) in Subjects With Chronic Back Pain.
Status: COMPLETED
Conditions: Back Pain
Interventions: DRUG: Buprenorphine transdermal patch|DRUG: Placebo oxycodone/acetaminophen tablets|DRUG: OXY/APAP|DRUG: Placebo transdermal patch (TDS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Ramipril and Felodipine Combination Therapy in Hypertension: An Effectiveness Study With Local Patients in Argentina
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Ramipril-Felodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Efficacy of SB Injection in Patients With Advanced or Primary Hepatocellular Carcinoma (HCC)
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: SB injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inositol in Trichotillomania
Status: COMPLETED
Conditions: Trichotillomania|Hair Pulling
Interventions: DRUG: Inositol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clofarabine, Cytarabine, and Thymoglobulin for Allogeneic Transplantation
Status: TERMINATED
Conditions: Myelodysplastic Syndromes|Acute Myeloid Leukemia
Interventions: DRUG: Clofarabine|DRUG: Cytarabine|DRUG: Thymoglobulin|PROCEDURE: Stem cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Fact Versus Myth Messages on Receipt of Influenza Vaccination
Status: COMPLETED
Conditions: Influenza Vaccination
Interventions: BEHAVIORAL: Fact Only Education Message|BEHAVIORAL: Fact and Myth Educational Message|BEHAVIORAL: Fact, Myth, Why Educational Message|BEHAVIORAL: Control Educational Message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Catholic Health Initiatives (CHI) St. Joseph's Children Home Visiting Longitudinal Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Child Development|Child Behavior|Child Abuse|Child Neglect|Parenting|Delinquency|Criminal Behavior
Interventions: BEHAVIORAL: home visiting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Travoprost 0.004% Versus Pilocarpine 1% in Patients With Chronic Angle Closure Glaucoma (CACG)
Status: COMPLETED
Conditions: Angle-closure Glaucoma
Interventions: DRUG: Travoprost 0.004% (Travatan)|DRUG: Pilocarpine 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Using Simulation to Support Staff and Improve Quality of Treatment: An Intervention Project Within Pediatrics
Status: ACTIVE_NOT_RECRUITING
Conditions: Medical Education|Pediatrics|Patient Outcomes
Interventions: BEHAVIORAL: Simulation-based team training intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conjugated Linoleic Acid and Atherosclerosis
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DIETARY_SUPPLEMENT: oil rich in cis9, trans11 conjugated linoleic acid|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OPT-821 With or Without Vaccine Therapy in Treating Patients With Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Peritoneal Cancer in Second or Third Complete Remission
Status: COMPLETED
Conditions: Stage IA Fallopian Tube Cancer|Stage IA Ovarian Cancer|Stage IB Fallopian Tube Cancer|Stage IB Ovarian Cancer|Stage IC Fallopian Tube Cancer|Stage IC Ovarian Cancer|Stage IIA Fallopian Tube Cancer|Stage IIA Ovarian Cancer|Stage IIB Fallopian Tube Cancer|Stage IIB Ovarian Cancer|Stage IIC Fallopian Tube Cancer|Stage IIC Ovarian Cancer|Stage IIIA Fallopian Tube Cancer|Stage IIIA Ovarian Cancer|Stage IIIA Primary Peritoneal Cancer|Stage IIIB Fallopian Tube Cancer|Stage IIIB Ovarian Cancer|Stage IIIB Primary Peritoneal Cancer|Stage IIIC Fallopian Tube Cancer|Stage IIIC Ovarian Cancer|Stage IIIC Primary Peritoneal Cancer|Stage IV Fallopian Tube Cancer|Stage IV Ovarian Cancer|Stage IV Primary Peritoneal Cancer
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Polyvalent Antigen-KLH Conjugate Vaccine|BIOLOGICAL: Saponin-based Immunoadjuvant OBI-821
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety Study of Bicifadine for the Treatment of Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: DRUG: Bicifadine|DRUG: Standard of Care (pharmacological analgesic treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Determine Radiation Exposure to Organs and Assess the Safety of CARDIOLITE® in Pediatric Subjects
Status: COMPLETED
Conditions: Kawasaki Disease
Interventions: DRUG: Technetium Tc99m Sestamibi
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Upifitamab Rilsodotin Maintenance in Platinum-Sensitive Recurrent Ovarian Cancer (UP-NEXT)
Status: TERMINATED
Conditions: High Grade Serous Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Cancer
Interventions: DRUG: Upifitimab rilsodotin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-Blind, Placebo-Controlled Study of Galantamine to Improve Cognitive Dysfunction in Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Galantamine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy for Insomnia: Face-to-Face Versus Telemedicine
Status: COMPLETED
Conditions: Insomnia
Interventions: BEHAVIORAL: Face to Face CBT-I (F2F)|BEHAVIORAL: Telemedicine CBT-I (TM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Non-significant Risk Clinical Study to Assess Perfusion Changes With Application of a TUS for Patients With PAD
Status: ACTIVE_NOT_RECRUITING
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: Therapeutic Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT