pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Safety and Dose Finding Trial of C-Tb, When Given to Adult Patients Recently Diagnosed With Active Tuberculosis
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: rdESAT-6 + rCFP-10 (C-Tb)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Experimental Study to Assess Interventions Aimed at Improving the Equity Impact of Community-Based Health Insurance
Status: COMPLETED
Conditions: Health Insurance
Interventions: BEHAVIORAL: After-sales service and supportive supervision (AfterSS)|BEHAVIORAL: Prospective reimbursement (PR)|BEHAVIORAL: Both (AfterSS and PR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Her-2/Neu in Patients With Metastatic Breast Cancer (AdHERe)
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: BIOLOGICAL: AdHer-2/neu transduced dendritic cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Prehabilitation on the Lean Mass Index (IMM) in ERAS PROGRAMM.
Status: UNKNOWN
Conditions: Colo-rectal Cancer|Nutrition Disorders
Interventions: OTHER: Prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Multi-session Anodal Cerebellar Transcranial Direct Current Stimulation (tDCS) vs Anodal Cerebral tDCS
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: OTHER: Cerebellar stimulation group (CbSG)|OTHER: Cerebral (M1) Stimulation group (MSG)|OTHER: Sham Stimulation group (SSG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Autoimmune Gastrointestinal Dysmotility: Symptoms, Pathogenesis and Treatment
Status: TERMINATED
Conditions: Dysmotility Syndrome|Autoimmunity
Interventions: OTHER: Current Intravenous Immunoglobulin (IVIG) treatment|OTHER: No Intravenous Immunoglobulin (IVIG) treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Aerosolized Versus Intravenous Colistin-based Antimicrobial Regimens in Hospitalized COVID-19 Patients With Bacterial Coinfection: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Secondary Bacterial Infection in COVID-19 Patients
Interventions: DRUG: Colistin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Proactive Therapeutic Drug Monitoring on Maintenance of Sustained Disease Control in Adults With Rheumatoid Arthritis on a Subcutaneous TNF Inhibitor: The Rheumatoid Arthritis Therapeutic DRUg Monitoring Trial (RA-DRUM)
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Therapeutic drug monitoring (TDM) of adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Colchicine on Food-related Effort-based Decision Making in Brain and Behaviour in Overweight and Obesity
Status: RECRUITING
Conditions: Overweight and Obesity
Interventions: DRUG: Colchicine 0.5 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Omega-3 Polyunsaturated Fatty Acids in Congestive Heart Failure
Status: TERMINATED
Conditions: Heart Failure
Interventions: DRUG: LOVAZA (Omega-3)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Genes That Affect Disease Outcome in Patients With Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: GENETIC: microarray analysis|GENETIC: mutation analysis|GENETIC: polymerase chain reaction|GENETIC: polymorphism analysis|OTHER: laboratory biomarker analysis|OTHER: questionnaire administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of Resorbable Prosthetic Mesh "Ante Rectus" as Prevention of Parastomal Hernia.
Status: RECRUITING
Conditions: Parastomal Hernia
Interventions: DEVICE: Mesh Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Low-intensity Focused Ultrasound and Autonomic Response
Status: ENROLLING_BY_INVITATION
Conditions: Autonomic Dysfunction
Interventions: DEVICE: Low-intensity focused ultrasound neuromodulation|DEVICE: Sham Low-intensity focused ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: HCU: Can VHVs Trained in ICCM Improve Care for Children
Status: COMPLETED
Conditions: Diarrhoea|Pneumonia|Malaria
Interventions: OTHER: Training of VHVs in iCCM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Treatment of Patients With Teduglutide (GLP-2) for GVHD and Analysis of Paneth Cells of GVHD Patients
Status: COMPLETED
Conditions: Graft Versus Host Disease
Interventions: DRUG: Teduglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Label Study of BIBW 2992/Afatinib in Advanced Non-Small Cell Lung Cancer Patients Pre-treated With Erlotinib or Gefitinib
Status: UNKNOWN
Conditions: NSCLC
Interventions: DRUG: Afatinib treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Propolis Tablet on the Saliva and the Amount of Adolescent Dental Plaque Microbes
Status: COMPLETED
Conditions: Dental Plaque
Interventions: DRUG: Propolis tablet to limit dental biofilm|DRUG: Xilytol tablet to limit dental biofilm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Early Child Development and Nutrition in Guatemala
Status: COMPLETED
Conditions: Undernutrition
Interventions: DIETARY_SUPPLEMENT: Micronutrients|BEHAVIORAL: Responsive feeding|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Safety and Therapeutic Activity of ANV419 in Patients With Advanced Cancer.
Status: RECRUITING
Conditions: Advanced Solid Tumor|Adult Disease|Lung Cancer
Interventions: DRUG: ANV419|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coronary Artery Disease After Heart Transplantation
Status: UNKNOWN
Conditions: Coronary Artery Disease in Transplanted Heart (Diagnosis)|Platelet Dysfunction
Interventions: DRUG: Aspirin 75mg|OTHER: Extracorporeal photopheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polymorphic Effects of Cytochrome P450 3A5 on Pharmacokinetics of Maraviroc and Its Metabolites
Status: COMPLETED
Conditions: Cytochrome P450 CYP3A5 Enzyme Polymorphism|Healthy Subjects|Pharmacokinetics of Maraviroc
Interventions: DRUG: Maraviroc
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bier's Block Versus Mini-bier's Block in Patients Undergoing Hand Surgery
Status: COMPLETED
Conditions: Surgery|Anesthesia, Local
Interventions: PROCEDURE: mini-Bier's block with lidocaine 0.5% 25ml|PROCEDURE: Conventional Bier's block with lidocaine 0.5% 40ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Metformin on Vascular and Mitochondrial Function in Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Compare the Clinical Efficacy of Prototype Toothpastes
Status: COMPLETED
Conditions: Dental Plaque
Interventions: DRUG: Fluoride|DRUG: Triclosan, fluoride|OTHER: Metal salt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open-Label Proof of Concept Study of VP-315 in Basal Cell Carcinoma
Status: RECRUITING
Conditions: Basal Cell Carcinoma|Skin Cancer|Cancer of the Skin, Basal Cell|Cancer of the Skin|Carcinoma
Interventions: DRUG: LTX-315 Part 1|DRUG: VP-315 Part 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Preservation of the Left Colic Artery on Rectum Cancer Surgery
Status: COMPLETED
Conditions: Rectum Cancer
Interventions: PROCEDURE: preserving the left colic artery|PROCEDURE: not preserving the left colic artery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fasting Study of Oxybutynin Chloride ER Tablets 10 mg and Ditropan XL® Tablets 10 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxybutynin Chloride ER Tablets 10 mg|DRUG: Ditropan XL® Tablets 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pilot Study of Haploidentical Donor Adenovirus Specific T-lymphocytes to Treat Refractory Adenovirus Infections
Status: RECRUITING
Conditions: Adenovirus Infection
Interventions: BIOLOGICAL: Adenovirus Specific T lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Osimertinib Plus Savolitinib in EGFRm+/MET+ NSCLC Following Prior Osimertinib
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma
Interventions: DRUG: osimertinib|DRUG: savolitinib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Methods to Treat Multiple Gingival Recession Defects
Status: TERMINATED
Conditions: Gingival Recession
Interventions: PROCEDURE: Coronally Advanced Flap|PROCEDURE: Intrasulcular Tunneling|BIOLOGICAL: Vestibular Incision Subperiosteal Tunnel Access (VISTA)|DEVICE: Leukocyte-Platelet Rich Fibrin (L-PRF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Additional Benefit of Thoracic Impedance Monitoring (TIM) for Propofol-sedation Monitoring During PEG Placement
Status: COMPLETED
Conditions: Percutaneous Endoscopic Gastrostomy (PEG)
Interventions: DEVICE: thoracic impedance monitoring|DEVICE: pulseoxymetry|DEVICE: non-invasive blood preassure monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diagnostic Efficacy Of 3 EUS-FNB Techniques
Status: RECRUITING
Conditions: Efficacy, Self
Interventions: DIAGNOSTIC_TEST: Dry suction technique (A)|DIAGNOSTIC_TEST: Slow-pull technique (B)|DIAGNOSTIC_TEST: Wet suction technique (C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluating the Efficacy and Safety of a Sequencing Schedule of Cobimetinib Plus Vemurafenib Followed by Immunotherapy With an Anti- PD-L1 Antibody in Patients With Unresectable or Metastatic BRAF V600 Mutant Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: DRUG: Vemurafenib|DRUG: Cobimetinib|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Tomudex & Iressa as Second Line Chemotherapy in Subjects With Colorectal Carcinoma
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Gefitinib, raltitrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Long-term Trial of OPA-15406 Ointment in Adult and Pediatric Patients With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: 0.3% OPA-15406 ointment|DRUG: 1% OPA-15406 ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Proof-of-Activity Study With Orticumab in Subjects With Psoriasis and Cardiometabolic Risk Factors
Status: COMPLETED
Conditions: Psoriasis|Inflammation|Coronary Artery Disease|Cardiometabolic Syndrome
Interventions: DRUG: Orticumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NOX-E36 First-in-Human (FIH) Study
Status: COMPLETED
Conditions: Chronic Inflammatory Diseases|Type 2 Diabetes Mellitus|Systemic Lupus Erythematosus
Interventions: DRUG: NOX-E36|DRUG: NOX-E36|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Patient Controlled Epidural Anesthesia Versus Continuous Epidural Analgesia for Post-thoracotomy Pain
Status: COMPLETED
Conditions: Acute Post-thoracotomy Pain
Interventions: PROCEDURE: Patient controlled epidural analgesia|PROCEDURE: Continuous epidural analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY2605541 (Insulin Peglispro) and Human Insulin Concentrations in Fat Tissue
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Insulin Peglispro|DRUG: Human Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of LDL Cholesterol in Patients Switched From 10 to 5 Milligrams of Zetia (Ezetimibe)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Ezetimibe 10 mg|DRUG: Ezetimibe 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Promoting Positive Outcomes for Individuals With ASD: Linking Early Detection, Treatment, and Long-term Outcomes
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Enhanced early detection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Cranberry Consumption Improves γδ T Cell Function
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Cranberry Beverage|OTHER: Placebo Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Endovascular Repair for Aortic Aneurysm (EVAR) Program at LHSC
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: PROCEDURE: Endovascular vs Open Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Analysis of Subcuticular Suture Materials in Cesarean Section
Status: NOT_YET_RECRUITING
Conditions: Cesarean Wound Disruption With Postnatal Complication
Interventions: PROCEDURE: polyglactin 910|PROCEDURE: poliglecaprone 25|PROCEDURE: polypropylene|PROCEDURE: polyester
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prophylactic Transfer of Leukemia-reactive T Cells After Allogeneic Transplantation
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia
Interventions: PROCEDURE: Application of activated donor T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Interventional Study for Patient With Cancer Pain to Evaluate the Efficacy and Safety of OxyNorm® Compared to Morphine Sulfate Through the IV Continuous Infusion.
Status: COMPLETED
Conditions: Cancer Pain
Interventions: DRUG: Oxycodone Hydrochloride|DRUG: Morphine Sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Improving Blood Pressure Control Through the myBPmyLife mHealth Application
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: Dietary and physical activity JITAI delivered through the myBPmyLife app|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Active Breathing Coordinator-based vs VisionRT-based Deep Inspiration Breath-hold for Radiation for Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DEVICE: Active Breathing Coordinator (ABC)|DEVICE: VisionRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Radical Pleurectomy With or Without Intraoperative PDT for Malignant Pleural Mesothelioma
Status: RECRUITING
Conditions: Epitheliod Malignant Pleural Mesothelioma
Interventions: RADIATION: Photodynamic Therapy|PROCEDURE: Radical Pleurectomy|RADIATION: Chemotherapy|DRUG: Photofrin 2.0 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CAR-T Immunotherapy Targeting CD19- ALL
Status: UNKNOWN
Conditions: B-cell Leukemia
Interventions: BIOLOGICAL: 4SCAR-CD22/CD123/CD38/CD10/CD20/TSLPR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Neoadjuvant Chemoradiotherapy in Comparison With Neoadjuvant Chemotherapy in Patients With Resectable Squamous Cell Esophageal Cancer
Status: RECRUITING
Conditions: Esophageal Cancer
Interventions: PROCEDURE: Patients undergoing neoadjuvant chemoradiotherapy plus Ivory-Lewis or McKeown esophagectomy.|PROCEDURE: Patients undergoing neoadjuvant chemotherapy plus Ivory-Lewis or McKeown esophagectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kissing as a Protective Factor Against Acidic pH in Saliva
Status: NOT_YET_RECRUITING
Conditions: Dental Caries|Tooth Demineralization|Teeth Erosion Limited to the Enamel
Interventions: OTHER: Kiss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study of the Effect of Two Experimental Lozenges on Oral Malodor After Single Use
Status: COMPLETED
Conditions: Oral Malodor
Interventions: OTHER: Experimental lozenge with the enzyme Polyphenol oxidase and green coffee extract|OTHER: Experimental lozenge with the enzyme Polyphenol oxidase, green coffee extract and flavor|OTHER: Placebo lozenge control (sorbitol only)|OTHER: No product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Research Study of How the Medicine Ziltivekimab Works in the Body of Chinese Men and Women With Kidney Disease and Inflammation
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Kidney Disease and Systemic Inflammation
Interventions: DRUG: Ziltivekimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Household Transmission Investigation Study for COVID-19 in Tropical Regions
Status: COMPLETED
Conditions: Coronavirus Infections|Severe Acute Respiratory Syndrome|SARS-CoV Infection
Interventions: PROCEDURE: Human biological samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Intracoronary Human Wharton's Jelly- Derived Mesenchymal Stem Cells (WJ-MSCs) Transfer in Patients With Acute Myocardial Infarction (AMI)
Status: COMPLETED
Conditions: ST-Elevation Myocardial Infarction
Interventions: GENETIC: intracoronary human umbilical WJ-MSC transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Laxative-probiotic Sequential Treatment in the Irritable Bowel Syndrome Patients
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Probiotic Clostridium Butyricum|DRUG: Laxative Polyethylene Glycol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Treatment Satisfaction in Adults With Chronic ITP After Switching to Avatrombopag From Eltrombopag or Romiplostim
Status: COMPLETED
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Avatrombopag Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Consumption of Beef on Appetite and Cognitive Function
Status: COMPLETED
Conditions: Obesity|Poor Glycemic Control|Dietary Interventions
Interventions: OTHER: Standard Protein-Plant, Even Distribution (SP-PLANT-EVEN)|OTHER: Standard Protein-Beef, Even Distribution (SP-BEEF-EVEN)|OTHER: High Protein-Beef, Even Distribution (HP-BEEF-EVEN)|OTHER: High Protein-Beef, Uneven Distribution (HP-BEEF-UNEVEN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Sitagliptin and Kinetics of Triglyceride-rich Lipoproteins Apolipoprotein B48 and B100 in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pumpkin Seed Oil Supplementation in Premenopausal Women
Status: COMPLETED
Conditions: Blood Pressure
Interventions: DIETARY_SUPPLEMENT: Pumpkin Seed Oil|DIETARY_SUPPLEMENT: Wheat Germ Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Morning Versus Evening Administration on The Pharmacokinetics and Pharmacodynamics of Empagliflozin
Status: COMPLETED
Conditions: Diabetes Mellitus|Pharmacokinetics|Pharmacodynamics
Interventions: DRUG: Empagliflozin 10 MG Oral Tablet [Jardiance]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Antibiotic De-escalation in Onco-hematology Patients for Sepsis or Septic Shock
Status: UNKNOWN
Conditions: Critical Care|Cancer
Interventions: OTHER: Antibiotic de-escalation|OTHER: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flu and Mood in Older Adults
Status: COMPLETED
Conditions: Vaccination|Infection
Interventions: OTHER: Standardised Digital Intervention|OTHER: Individualised Digital Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: High Dose D-Serine as Adjuvant Treatment for Recent Onset Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DRUG: D-serine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Comparative Study of E2022 Current and New Patch Formulations
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: E2022- Current Formula Tape|DRUG: E2022- New Formula Tape|DRUG: E2022 Matching Placebo- Current Formula Tape|DRUG: E2022 Matching Placebo- New Formula Tape
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Response to Biomarker Documentation of Child Secondhand Smoke Exposure
Status: UNKNOWN
Conditions: Biomarker Feedback|Smoking Cessation|Secondhand Smoke Exposure|Provider Behavior
Interventions: BEHAVIORAL: Biomarker Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Magnetic-controlled Capsule Endoscopy vs. Gastroscopy for Detection of Gastric Diseases
Status: COMPLETED
Conditions: Gastric Diseases,|Gastric Ulcer,|Gastric Polyps,|Early Gastric Cancer,|Chronic Gastritis
Interventions: DEVICE: MCE|DEVICE: Standard gastroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: DNS-7801 vs. Placebo in Parkinson's Disease
Status: TERMINATED
Conditions: Parkinson's Disease
Interventions: DRUG: DNS-7801 (low-dose)|DRUG: DNS-7801 (high dose)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Gelesis200 on Body Weight in Overweight and Obese Subjects w/o Type 2 Diabetes
Status: UNKNOWN
Conditions: Overweight|Diabetes|PreDiabetes|Obesity
Interventions: DEVICE: Gelesis200|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hybrid-everted Versus Hand-sewn or Stapled Esophagogastrostomy in Prevention of Anastomotic Stricture
Status: COMPLETED
Conditions: Esophageal Neoplasms|Surgical Stomas
Interventions: OTHER: hybrid everted esophagogastric anastomosis|OTHER: the conventional hand-sewn anastomosis|OTHER: a stapled anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Monitoring of Prophylactic Effect of Hydroxychloroquine in Healthcare Providers Highly Exposed to COVID-19
Status: WITHDRAWN
Conditions: COVID
Interventions: DRUG: Hydroxychloroquine|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Real-Time Assessment Of Breast Cancer Lumpectomy Specimen Margins With Nonlinear Microscopy
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DEVICE: nonlinear microscopy imaging of excised surgical margins|PROCEDURE: standard lumpectomy without nonlinear microscopy imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pain Control Following Renal Transplant
Status: TERMINATED
Conditions: Kidney Transplant; Complications|Pain, Postoperative
Interventions: DRUG: Intravenous Lidocaine|DRUG: Transversus abdominis plane (TAP) block|DRUG: Quadratus Lumborum (QL) Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial of Ado-Trastuzumab Emtansine for Patients With HER2 Amplified or Mutant Cancers
Status: RECRUITING
Conditions: Solid Tumor Cancers|Lung Cancer|Bladder Cancer|Urinary Tract Cancers
Interventions: DRUG: ado-trastuzumab emtansine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Docetaxel +153 Sm-EDTMP in Patients With Hormone-Refractory Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Docetaxel|DRUG: Docetaxel|DRUG: Docetaxel|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial in Children Between 3 Months and 14 Years Old to Evaluate the Efficacy and Safety of Gelatin Tannate in the Treatment of Acute Diarrhea (INDIGO)
Status: COMPLETED
Conditions: Diarrhea
Interventions: COMBINATION_PRODUCT: Gelatin tannate (GT) + oral rehydration solution (ORS) + Zinc supplementation|COMBINATION_PRODUCT: placebo + ORS + Zinc supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of CYC140, a PLK-1 Inhibitor, in Advanced Leukemias or MDS
Status: UNKNOWN
Conditions: AML, Adult|Myelodysplastic Syndromes|ALL, Adult|CML, Refractory|CLL, Refractory
Interventions: DRUG: CYC140
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Right Question Project-Mental Health: An Intervention to Increase Engagement and Retention in Mental Health Care
Status: COMPLETED
Conditions: Mental Disorders
Interventions: BEHAVIORAL: Right Question Project - Mental Health (RQP-MH)|BEHAVIORAL: Pamphlet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Mono Unsaturated Fatty Acids in Obesity - Weight Maintenance and Prevention of Lifestyle Diseases in Obese Subjects.
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: BEHAVIORAL: Mono Unsaturated Fatty Acids in Obesity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Efficacy and Safety Study of Genolar® and Xolar® in the Persistent Atopic Bronchial Asthma
Status: COMPLETED
Conditions: Bronchial Asthma
Interventions: BIOLOGICAL: Genolar® + Symbicort®|BIOLOGICAL: Xolair® + Symbicort®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: myoARRAY and TcLandscape Analysis for the Diagnosis of Inflammatory Myopathies
Status: COMPLETED
Conditions: Polymyositis|Dermatomyositis
Interventions: OTHER: transcriptome analysis|OTHER: T cell repertoire analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Investigation Of The Absorption And Pharmacokinetics Of A Single Dose Of A Controlled Release (CR) Pregabalin Tablet Following A Low, Medium, And High-Fat Evening Meal As Compared To A Single Dose Of The Immediate Release (IR) Pregabalin Capsule In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pregabalin controlled release, 330 mg, low-fat|DRUG: Pregabalin controlled release, 330 mg, medium-fat|DRUG: Pregabalin controlled release, 330 mg, high-fat|DRUG: Pregabalin immediate release, 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Efruxifermin in Non-Cirrhotic Subjects With Histologically Confirmed Nonalcoholic Steatohepatitis (NASH)
Status: ACTIVE_NOT_RECRUITING
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: DRUG: EFX|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Adding Nalbuphine to Intrathecal Morphine on Analgesic Efficacy and Side Effects After Cesarean Section
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Morphine|DRUG: Morphine plus Nalbuphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Safety and Efficacy of Caelyx in Combination With Cyclophosphamide in the Treatment of Metastatic Breast Cancer (P02948)
Status: COMPLETED
Conditions: Breast Neoplasm
Interventions: DRUG: Pegylated Lyposomal Doxorubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine
Status: NOT_YET_RECRUITING
Conditions: Nicotine Dependence|Nicotine Vaping
Interventions: DRUG: (S)-Nicotine|DRUG: (R)- nicotine|DRUG: Racemic nicotine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reduced-intensity, Related-donor Bone Marrow Transplantation Followed by High-dose Cyclophosphamide for Hematologic Cancers
Status: TERMINATED
Conditions: Lymphoma|Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: Fludarabine|DRUG: Busulfan|DRUG: Cyclophosphamide|DRUG: Mycophenolate Mofetil|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Disordered Breathing in Gulf War Illness and the Effect of Nasal CPAP Treatment
Status: COMPLETED
Conditions: Apnea, Sleep|Chronic Fatigue Syndrome
Interventions: OTHER: Nasal CPAP treatment during sleep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: NUTRITION: Natural Tocotrienol Against Ischemic Stroke Event
Status: COMPLETED
Conditions: Ischemic Stroke|Transient Ischemic Attack (TIA)
Interventions: OTHER: Vitamin E tocotrienol (TCT) capsules ; Low dose Aspirin|OTHER: Placebo vehicle control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Scalpel Versus Electrocautery for Surgical Skin Incision in Open Carpal Tunnel Release
Status: TERMINATED
Conditions: Carpal Tunnel Syndrome
Interventions: PROCEDURE: Electrocautery|PROCEDURE: Scalpel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Anti-Androgen Treatment for COVID-19
Status: COMPLETED
Conditions: COVID-19|SARS-CoV2|Androgenetic Alopecia|Prostate Cancer|Benign Prostatic Hyperplasia|SARS (Severe Acute Respiratory Syndrome)
Interventions: DRUG: Proxalutamide|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomedine Infusion Versus Fentanyl Infusion for Donor Anlgesia During Living Donor Hepatectomy
Status: COMPLETED
Conditions: Donor Hepatectomy
Interventions: DRUG: dexmedetomedine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Dose-response of Cannabis and Driving
Status: COMPLETED
Conditions: Driving Impaired|Cognitive Impairment|Abuse Cannabis
Interventions: DRUG: Cannabis|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Exploratory Study of Pembrolizumab Plus Entinostat in Non-Inflamed Stage III/IV Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Entinostat|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Energy Balance Following Islet Transplantation
Status: TERMINATED
Conditions: Type 1 Diabetes
Interventions: DEVICE: Accelerometer|OTHER: Anthropomentry|PROCEDURE: Blood tests|DEVICE: BODPOD|PROCEDURE: MRI (Magnetic Resonance Imaging)|OTHER: Food Diary|DEVICE: CGMS (Continuous Glucose Monitoring System)|OTHER: Questionnaire and Hypo Score|PROCEDURE: Mixed Meal Tolerance Test (MMTT)|PROCEDURE: Indirect Calorimetry|DRUG: Doubly Labelled Water|DRUG: Hepatic Mitochondrial Oxidation breath test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Anesthetic Agents on Optic Nerve Sheath Diameter
Status: COMPLETED
Conditions: Uterus Myoma|Uterine Cancer
Interventions: DRUG: Sevoflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: J-Pouch vs Side-to-End Anastomosis After Hand-Assisted Laparoscopic Low Anterior Resection for Rectal Cancer
Status: COMPLETED
Conditions: Quality of Life|Fecal Incontinence|Postoperative Complications
Interventions: DEVICE: Linear cutter-Circular stapler|DEVICE: Circular stapler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Participants With Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: TTS-fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alcohol Control in Smoking Cessation
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Standard Smoke Cessation Service|BEHAVIORAL: Short Advice for Control Group|BEHAVIORAL: Brief Alcohol Intervention for Intervention Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-Invasive Mapping of Cerebral Autoregulation Using Near Infrared Spectroscopy
Status: RECRUITING
Conditions: Cerebral Autoregulation Mapping
Interventions: PROCEDURE: Transient hyperemic response|PROCEDURE: Orthostatic challenge|PROCEDURE: Vascular chemo-reactivity|PROCEDURE: Neurovascular coupling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Preoperative Nutritional Status and Postoperative Outcomes in Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: Nutrition Risk Screening 2002 (NRS-2002)|DIAGNOSTIC_TEST: Global Leadership Initiative on Malnutrition (GLIM)|OTHER: Measurement of body composition with computed tomography (CT)|DIAGNOSTIC_TEST: Dietary inflammatory index (DII)|DIAGNOSTIC_TEST: European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQ-C30)|DIAGNOSTIC_TEST: European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Colorectal Cancer 29 (EORTC-QLQ-CR29)|DIAGNOSTIC_TEST: Prognostic Nutritional Index (PNI)|DIAGNOSTIC_TEST: Neutrophil-Lymphocyte Ratio (NLR)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Roflumilast on Exacerbation Rate in Patients With Chronic Obstructive Pulmonary Disease. Ratio-Study. (BY217/M2-112)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|COPD
Interventions: DRUG: Roflumilast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Daratumumab in Combination With Lenalidomide and Dexamethasone in Relapsed and Relapsed-refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Part 1 (Dose Escalation): Daratumumab|DRUG: Part 2 (Dose Expansion): Daratumumab|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Half-Dose Intracoronary Abciximab Bolus Improves the Mortality Outcome Compared to Standard Intravenous Regimen
Status: TERMINATED
Conditions: Coronary Disease|Myocardial Infarction
Interventions: DRUG: abciximab
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: A Study to Evaluate the Pharmacokinetics of Intranasal Esketamine Administered With and Without a Nasal Guide on the Intranasal Device
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Esketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resveratrol for Improved Performance in the Elderly
Status: COMPLETED
Conditions: Memory
Interventions: DIETARY_SUPPLEMENT: Placebo|DRUG: Low dose Resveratrol|DRUG: High dose Resveratrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Phase I Dose-Escalation, Safety, Pharmacokinetic and Pharmacodynamic Study of BVD-523 in Patients With Advanced Malignancies
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: BVD-523
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-center, Early Feasibility Study of Using the Mechanical Tissue Resuscitation™ (MTR™) Therapy System for Removal of Excess Fluid in Subjects Who Have Had a Portion of Their Skull Removed to Expose the Dura/Brain and Require Drainage for Fluid Removal.
Status: NOT_YET_RECRUITING
Conditions: Clinical Need for Craniotomy or Craniectomy
Interventions: DEVICE: Mechanical Tissue Resuscitation (MTR™)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Recent-Onset Type 1 Diabetes Trial Evaluating Efficacy and Safety of Teplizumab
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: BIOLOGICAL: teplizumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of the Pulsed Electric Field Ablation System in Treating Chronic Bronchitis
Status: RECRUITING
Conditions: Chronic Bronchitis
Interventions: DEVICE: Pulse electric field ablation system developed by Zhouling (Shanghai) Medical Appliance Co., Ltd.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Radiofrequency Ablation (RFA) of Symptomatic Uterine Fibroids
Status: COMPLETED
Conditions: Uterine Fibroids|Uterine Myomas
Interventions: DEVICE: Halt Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anlotinib Plus PD-1 Inhibitor as 2nd-line Threapy in Patients With Metastatic Pancreatic Cancer
Status: RECRUITING
Conditions: Overall Survival
Interventions: DRUG: Anlotinib, PD-1 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Rapid Mobilisation Improve Length of Stay and Outcomes Post THR
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Hip|Hip Replacement, Total
Interventions: PROCEDURE: Attempt walking from 4 hours post operatively, on the day of their surgery.|PROCEDURE: Control - standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continued Treatment With Docetaxel Versus Switch to Cabazitaxel After Minor Prostate Specific Antigen Response to Docetaxel in Patients With Castration-Resistant Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: CABAZITAXEL (XRP6258)|DRUG: DOCETAXEL (XRP6976)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test How Well Different Doses of BI 1569912 Are Tolerated and How Well They Work in People With Depression Who Take Anti-depressive Medication
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: BI 1569912|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Expect Respect Middle School Randomized Trial
Status: COMPLETED
Conditions: Adolescent Behavior|Violence in Adolescence|Group, Peer|Violence, Non-accidental|Violence, Sexual|Violence, Physical|Violence, Domestic|Emotional Abuse|Coping Skills|Communication, Personal
Interventions: BEHAVIORAL: Expect Respect|BEHAVIORAL: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION