pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Nab-P and Gem Compared With Gem and Tegafur in Adjuvant Chemotherapy After Radical Resection of Pancreatic Cancer
Status: UNKNOWN
Conditions: Stage IA Pancreatic Adenocarcinoma|Stage IB Pancreatic Adenocarcinoma|Stage IIA Pancreatic Adenocarcinoma|Stage IIB Pancreatic Adenocarcinoma
Interventions: DRUG: nab-paclitaxel|DRUG: Gemcitabine|DRUG: tegafur
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of NI-071 in Comparison With Remicade in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Infliximab|BIOLOGICAL: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tailored Treatment to Enhance Risk Perception in Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea (OSA)
Interventions: BEHAVIORAL: Brief Personalized Video (BPV)|BEHAVIORAL: Non-Personalized Video (NPV)|BEHAVIORAL: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Initial Case Series With Exalt Single-Use Duodenoscope
Status: COMPLETED
Conditions: Endoscopic Retrograde Cholangiopancreatography
Interventions: DEVICE: Exalt Model D Single-Use Duodenoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Factors Affecting Post-treatment Outcomes in Patients With Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DEVICE: Radiofrequency ablation|DRUG: Trance-arterial chemoembolization|PROCEDURE: Liver resection|COMBINATION_PRODUCT: Combined radiofrequency ablation + percutaneous ethanol injection|DRUG: Percutaneous ethanol injection|DRUG: Systemic chemotherapy|DRUG: Sorafenib|DIETARY_SUPPLEMENT: Viscum|DRUG: Symptomatic treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Catheter Versus Thoracoscopic Surgical Ablation Strategy in Persistent Atrial Fibrillation
Status: UNKNOWN
Conditions: Persistent Atrial Fibrillation
Interventions: PROCEDURE: Thoracoscopically Assisted Surgical Ablation|PROCEDURE: Catheter Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RAMIE Versus MIE for Resectable Esophageal Cancer, a Randomized Controlled Trial (ROBOT-2 Trial).
Status: RECRUITING
Conditions: Esophageal Adenocarcinoma
Interventions: PROCEDURE: Minimally invasive esophagectomy|DEVICE: daVinci Xi system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect and Safety of Plum-blossom Needle for Tourette Syndrome
Status: UNKNOWN
Conditions: Tourette Syndrome
Interventions: OTHER: Plum-blossom needle group|BEHAVIORAL: HRT group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Oral Hygiene Instructions on Proinflammatory Cytokines Among Cigarette Smokers and Individuals Vaping Electronic Cigarettes During Plaque Induced Gingivitis (Clinical Trial)
Status: NOT_YET_RECRUITING
Conditions: Electronic Cigarette Use|Plaque Induced Gingivitis
Interventions: BEHAVIORAL: oral hygiene instructions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy of ALMB-0168 in Solid Tumor Patients With Bone Metastatic Whose Prior Standard Treatment Have Failed
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumors With Bone Only Metastasis
Interventions: DRUG: ALMB-0168
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Change in Weight After 24 Weeks Treatment With LIK066 in Obese or Overweight Adults
Status: COMPLETED
Conditions: Obesity|Overweight
Interventions: DRUG: LIK066|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gluten and (Extra-)Intestinal Symptoms in NCGS
Status: COMPLETED
Conditions: Non-celiac Gluten Sensitivity
Interventions: OTHER: Expectancy and gluten
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study of Pegylated Somatropin to Treat Children Growth Hormone Deficiency
Status: UNKNOWN
Conditions: Growth Hormone Deficiency
Interventions: BIOLOGICAL: PEG-somatropin|BIOLOGICAL: PEG-somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Clinical Trial to Evaluate OC-01 Nasal Spray in Subjects With Neurotrophic Keratopathy
Status: COMPLETED
Conditions: Neurotrophic Keratopathy
Interventions: DRUG: OC-01 (varenicline) nasal spray 1.2 mg/ml|DRUG: Placebo (vehicle) nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of OMT on Patients With COPD: Correlating Pulmonary Function Tests With Biochemical Alterations
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: PROCEDURE: Osteopathic Manipulative Treatment (OMT)|OTHER: sham omt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test How Well Healthy Men and Women Tolerate Different Doses of BI 706321
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: BI 703621|DRUG: Placebo|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Etiologic Treatment With Benznidazole in Adult Patients With Chronic Chagas Disease. A Randomized Clinical Trial
Status: COMPLETED
Conditions: Chagas Disease
Interventions: DRUG: Benznidazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MBC Physical Activity Study
Status: NOT_YET_RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Breast Carcinoma
Interventions: OTHER: Exercise Intervention|OTHER: Exercise Intervention|OTHER: Exercise Intervention|OTHER: Health Promotion and Education|OTHER: Internet-Based Intervention|OTHER: Physical Activity|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Potential Osteocatabolic Effect Caused by Anti-CGRP mAbs in Migraine Patients Treated With Anti-CGRP mAbs - an Observational Pilot Project With Prospectively Collected Health Related Data
Status: RECRUITING
Conditions: Migraine Disorders
Interventions: DIAGNOSTIC_TEST: Diagnostic radiology
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Traditional Chinese Medicine for the Treatment of Perennial Allergic Rhinitis on Gut Microbiota and Immune-modulation
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Shin-yi-san + Xiao-qing-long-tang + Xiang-sha-liu-jun-zi-tang by the weight of 9g+3g+3g/day
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of "Oral Administration of Breast Milk Droplets" and "Palatal Stimulation With a Finger"
Status: COMPLETED
Conditions: Infants
Interventions: BEHAVIORAL: palatal stimulation with a finger in premature infants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Sequential TACE and PVE on the Resectability of Hepatitis B Related HCC
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: TACE|PROCEDURE: PVE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-National Study In Bladder Cancer Patients to Detect Recurrences After TURB (Trans-urethral Resection of the Bladder) Earlier With the Xpert Bladder Cancer Monitor Assay (ANTICIPATE X)
Status: COMPLETED
Conditions: Non-muscle-invasive Bladder Cancer
Interventions: DIAGNOSTIC_TEST: Xpert Bladder Cancer Monitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: N-acetylcysteine for Tobacco Use Disorder
Status: COMPLETED
Conditions: Nicotine Dependence|Smoking
Interventions: DRUG: N-acetylcysteine (NAC)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Using Superimposition of Intra-Oral Scan and CBCT in Single Implant Restorations in Aesthetic Zone.
Status: ENROLLING_BY_INVITATION
Conditions: Dental Implant|Patient Satisfaction
Interventions: OTHER: superimposition of DICOM file from CBCT and STL file of Intraoral scanner
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Improving Access to Cervical Cancer Screening
Status: UNKNOWN
Conditions: Uterine Cervical Neoplasms
Interventions: BEHAVIORAL: 'Pap smear' arm|BEHAVIORAL: 'Self-collected vaginal swab for HPV testing + pap smear triage' arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Evaluation of the Efficacy of Intralesional Injection of Combined Digoxin and Furosemide Versus 5 - Fluorouracil in Treatment of Plantar Warts
Status: UNKNOWN
Conditions: Plantar Wart
Interventions: DRUG: combined digoxin and furosemide|DRUG: 5 fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DHEA Augmentation of Musculoskeletal Adaptations to Exercise in Older Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Low Bone Mass|Osteoporosis, Postmenopausal
Interventions: OTHER: DHEA|OTHER: Placebo|BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Acute Nerve Decompression Versus Non-operative Treatment for Peroneal Nerve Palsy Following Primary Total Knee Arthroplasty
Status: WITHDRAWN
Conditions: Peroneal Palsy (Foot Drop)
Interventions: PROCEDURE: Nerve decompression|OTHER: Non-operative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobilization of Endothelial Progenitor Cells and Aspirin
Status: TERMINATED
Conditions: Hypertrophic Obstructive Cardiomyopathy
Interventions: DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Traditional Balance vs Vibrotactile Feedback Training for Vestibular Rehabilitation
Status: COMPLETED
Conditions: Traumatic Brain Injury|Vestibular Deficits
Interventions: DEVICE: Sensory Kinetics Balance System|OTHER: Traditional Vestibular Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antibiotic Concentration After Delivery to Middle Ear for Chronic Suppurative Otitis Media
Status: COMPLETED
Conditions: Chronic Suppurative Otitis Media
Interventions: OTHER: Aspiration of middle ear fluid following standard-of-care delivery of ciprofloxacin and dexamethasone suspension
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Blood Flow and Vascular Function in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Sildenafil (Acute-1 hour)|DRUG: Sildenafil (Subchronic-4 weeks)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Spondylitis Trial of Apremilast for Better Rheumatic Therapy
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: DRUG: Apremilast|DRUG: Placebo (sugar pill)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Assessment of Sarcopenia in Patients With Chronic Liver Disease: the SARCOLIVER Study
Status: RECRUITING
Conditions: Liver Cirrhosis|Non-Alcoholic Fatty Liver Disease|Hepatocellular Carcinoma
Interventions: DIAGNOSTIC_TEST: Handgrip strength test|DIAGNOSTIC_TEST: total body Dual Energy X-Ray Absorptiometry (DXA)|DIAGNOSTIC_TEST: Muscle ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Characteristics and Prognostic Factors of Atrial Fibrillation at a Tertiary Center of Pakistan - From a South-Asian Lens - a Retrospective Study.
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: OTHER: No intervention, as this was retrospective study.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Time-restricted Eating Supported by Mobile Technology in Patients With Non-alcoholic Fatty Liver Disease: Randomized Controlled Trial
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease|Time Restricted Feeding|Mobile Technology
Interventions: BEHAVIORAL: Mobile application and wearable device|BEHAVIORAL: Time-restricted eating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Support Via Online Social Networks to Promote Safe Infant Care Practices
Status: RECRUITING
Conditions: Breastfeeding|Infant Death|Sudden Infant Death Syndrome Without Mention of Autopsy
Interventions: BEHAVIORAL: Safe Sleep|BEHAVIORAL: Breastfeeding|BEHAVIORAL: Early Brain Development and Parent-Child Relationships
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Personalized Cardiovascular Risk Information to Initiate and Maintain Health Behavior Changes
Status: COMPLETED
Conditions: Cardiovascular Disease|Peripheral Artery Disease|Ischemic Stroke|Diabetes
Interventions: BEHAVIORAL: Web-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Breaking of Sitting Time Prevents Lower Leg Swelling
Status: COMPLETED
Conditions: Edema Leg
Interventions: BEHAVIORAL: Uninterrupted motionless standing|BEHAVIORAL: Uninterrupted motionless sitting|BEHAVIORAL: Sit-to-stand transitions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Maintenance Therapy With Histamine Dihydrochloride and Interleukin-2 in Adult Acute Myeloid Leukemia (AML) Patients With Measurable Minimal Residual Disease (MRD)- a Non-interventional Study (NIS)
Status: TERMINATED
Conditions: Acute Myeloid Leukemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CNS Dose Escalation/Expansion of Tepotinib in MET-driven NSCLC
Status: TERMINATED
Conditions: Advanced Non-Small Cell Lung Cancer With MET Mutations
Interventions: DRUG: Tepotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Propofol-dexmedetomidine on Immune Function in Patients With Cancer Larynx
Status: COMPLETED
Conditions: Cancer Larynx|Total Laryngectomy
Interventions: DRUG: Propofol group|DRUG: Isoflurane group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Non-pharmacological Analgesic Effects on Term Newborns
Status: COMPLETED
Conditions: Pain|Breast Feeding
Interventions: BEHAVIORAL: breastfeeding|DIETARY_SUPPLEMENT: oral sucrose|BEHAVIORAL: Skin-to-Skin contact|BEHAVIORAL: Non-nutritive sucking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palliative Care During Intraperitoneal Chemotherapy in Patients With Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: intraperitoneal chemotherapy|OTHER: educational intervention|OTHER: medical chart review|OTHER: questionnaire administration|PROCEDURE: assessment of therapy complications|PROCEDURE: end-of-life treatment/management|PROCEDURE: psychosocial assessment and care|PROCEDURE: quality-of-life assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open Label, Sequential-dose Study of PA5108 Latanoprost FA SR Ocular Implant for Mild-moderate Glaucoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Open Angle Glaucoma
Interventions: DRUG: PA5108 Latanoprost FA SR Ocular Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nano-Hybrid vs Bulk-Fill Resin Composites
Status: COMPLETED
Conditions: Composite Resin|Dental Caries in Children
Interventions: DEVICE: Bulk-fill composite resin|DEVICE: Nano-fill composite resin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Circuit-Based Approach to Suicide: Biomarkers, Predictors, and Novel Therapeutics
Status: RECRUITING
Conditions: Major Depressive Episode|Borderline Personality Disorder|Suicide
Interventions: DEVICE: Intermittent Theta Burst Transcranial Magnetic Stimulation (Active)|DEVICE: Intermittent Theta Burst Transcranial Magnetic Stimulation (Sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Maintenance Treatment (Trastuzumab and Pertuzumab) After Initial Chemotherapy in a Phase Ib/II Trial for Advanced HER2 Positive Breast Cancer
Status: TERMINATED
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|HER2-Positive Breast Carcinoma|Metastatic Breast Carcinoma
Interventions: DRUG: Copanlisib|BIOLOGICAL: Pertuzumab|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Combination of Anetumab Ravtansine With Either Nivolumab, Nivolumab and Ipilimumab, or Gemcitabine and Nivolumab in Advanced Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Adenocarcinoma|Stage II Pancreatic Cancer AJCC v8|Stage III Pancreatic Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8
Interventions: BIOLOGICAL: Anetumab Ravtansine|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Gemcitabine Hydrochloride|BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Topical SOR007 Ointment for Cutaneous Metastases
Status: COMPLETED
Conditions: Cutaneous Metastasis
Interventions: DRUG: SOR007 (Uncoated Nanoparticle Paclitaxel) Ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Real World Study of Bamlanivimab in Participants With Mild-to-Moderate Coronavirus Disease 2019 (COVID-19)
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Bamlanivimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Effectiveness of Non-invasive Neuromodulation Treatment for Improving Sexual Satisfaction in Healthy Subjects.
Status: NOT_YET_RECRUITING
Conditions: Sexual Satisfaction
Interventions: DEVICE: Non-Invasive Neuromodulation (NESA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PURE-HF: Peripheral Ultrafiltration for the RElief From Congestion in Heart Failure
Status: TERMINATED
Conditions: Heart Failure|Acute Heart Failure
Interventions: DEVICE: CHIARA-System|OTHER: Usual care IV diuretics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy and Safety of Parsaclisib in Participants With Primary Warm Autoimmune Hemolytic Anemia
Status: TERMINATED
Conditions: Warm Autoimmune Hemolytic Anemia (wAIHA)
Interventions: DRUG: parsaclisinib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Three Drug Combinations Containing Clarithromycin in the Treatment of Mycobacterium Avium Complex (MAC) Disease in Patients With AIDS
Status: COMPLETED
Conditions: Mycobacterium Avium-intracellulare Infection|HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Ritonavir|DRUG: Ethambutol hydrochloride|DRUG: Clarithromycin|DRUG: Rifabutin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Treatment of Patients With Early Septic Shock and Bio-Adrenomedullin(ADM) Concentration > 70 pg/ml With ADRECIZUMAB
Status: COMPLETED
Conditions: Septic Shock
Interventions: BIOLOGICAL: Adrecizumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Clinical Effects of Twice-daily Doses of Cinacalcet (AMG 073) in Adults With Primary Hyperparathyroidism (HPT)
Status: COMPLETED
Conditions: Primary Hyperparathyroidism
Interventions: DRUG: Cinacalcet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Dabrafenib and Trametinib Combination Therapy in Japanese Patients With BRAF V600E Stage IV NSCLC
Status: WITHDRAWN
Conditions: Non-Small-Cell Lung Cancer
Interventions: DRUG: Dabrafenib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dancing for Better Aging: Evaluating the Impact of a Dance/Movement Therapy (D/MT) Program for Older Adults
Status: COMPLETED
Conditions: Aging
Interventions: OTHER: Dance/Movement Therapy (DMT)|OTHER: Aerobics Exercise (AE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: IN10018 Combination Therapy in Treatment-naïve ES-SCLC
Status: RECRUITING
Conditions: Small Cell Lung Cancer Extensive Stage
Interventions: DRUG: IN10018|DRUG: Tislelizumab|DRUG: Carboplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spinal Cord Stimulation for Predominant Low Back Pain
Status: COMPLETED
Conditions: Failed Back Surgery Syndrome|Back Pain|Pain in Leg, Unspecified
Interventions: DEVICE: Spinal Cord Stimulation (SCS)|DRUG: Optimal Medical Management (OMM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Statin Reminders for Improving Prescribing in Primary Care
Status: ENROLLING_BY_INVITATION
Conditions: Cholesterol, Elevated|Clinical Decision Support|Education
Interventions: OTHER: Interruptive Reminder|OTHER: Non-interruptive Reminder|OTHER: No Reminder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Duvelisib in Combination With Nivolumab in Patients With Advanced Unresectable Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Unresectable Melanoma
Interventions: DRUG: Nivolumab|DRUG: Duvelisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Look at and Compare How Inhaled and Intravenous Fluticasone Furoate and GW642444 Are Processed by the Body in Healthy Subjects
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: fluticasone furoate//GW642444|DRUG: fluticasone furoate|DRUG: GW642444
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Transrectal Perilesional Biopsy in Diagnosis of Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: PROCEDURE: Transrectal perilesional/regional systematic biopsy (PB/RSB)|PROCEDURE: Combination of transrectal systematic biopsy and targeted biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Metabolic Effects of Early Time-restricted Carbohydrate Consumption
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Obesity|Nutrition, Healthy|Weight Loss
Interventions: BEHAVIORAL: eTRC diet|BEHAVIORAL: Control diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Crossover Study in Healthy Subjects to Evaluate the PK Profile of KVD824 Following Single and Multiple Doses of Modified Release (MR) Formulations
Status: COMPLETED
Conditions: Hereditary Angioedema
Interventions: DRUG: KVD824 Prototype 1 modified-release tablet|DRUG: KVD824 Prototype 2 modified-release tablet|DRUG: KVD824 Immediate-Release Capsule|DRUG: Placebo to KVD824 Prototype 1|DRUG: KVD824 Prototype 3 modified-release tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Respiratory Rate Derived From Capnography in Sedated Patients
Status: COMPLETED
Conditions: Sedation Problems
Interventions: PROCEDURE: Standard capnography|PROCEDURE: Modified capnography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Study of IMC-A12 in Patients With Mesothelioma Who Have Been Previously Treated With Chemotherapy
Status: COMPLETED
Conditions: Pleural Mesothelioma|Peritoneal Mesothelioma
Interventions: DRUG: IMC-A12
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Remote-based Resistance Training on Cardiometabolic Risk Factors, Cognitive Function, and Quality of Life in Adults Living With Alzheimer's Disease and/or Related Dementias
Status: UNKNOWN
Conditions: Dementia|Alzheimer Disease|Dementia, Vascular|Lewy Body Disease|Frontotemporal Dementia|Mild Cognitive Impairment|Aging|Hypertension|Obesity, Abdominal|Obesity|Body Weight|Blood Pressure|Blood Glucose, High|Blood Glucose, Low|Dyslipidemias|Quality of Life|Cognitive Impairment
Interventions: OTHER: Remote-based Resistance Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Chemo-Radiotherapy in Patients With Resectable and Borderline Resectable Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreas Neoplasm Malignant Resectable
Interventions: DRUG: Folfox6|DRUG: Gemcitabine|RADIATION: Radiation Therapy|PROCEDURE: Pancreaticoduodenectomy with retroperitoneal lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Ginsenoside Compound K (GCK) Tablet in Patients With Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Early Rheumatoid Arthritis
Interventions: DRUG: GCK 100 mg + Placebo 200 mg|DRUG: GCK 200 mg + Placebo 100 mg|DRUG: GCK 300 mg|DRUG: Placebo 300mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Subcutaneously-Injected Prandial INSULIN-PH20 NP Compared to Insulin Lispro Injection in Participants With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Insulin Lispro|DRUG: regular human insulin|DRUG: recombinant human hyaluronidase PH20|DRUG: Insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: W0265-104: A Single-Center, Evaluator-Blinded, Randomized, Placebo-Controlled, Phase 1 Clinical Trial Evaluating the Photoallergic Potential of Topically Applied Clindamycin Phosphate 1.0% and Tretinoin 0.025% (CT Gel) in Healthy Volunteers
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: clindamycin1%/tretinoin 0.025% gel|DRUG: vehicle gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Coconut Water on Varsity Basketball Performance
Status: UNKNOWN
Conditions: Water|Gatorade|Coconut Water
Interventions: OTHER: Coconut Water|OTHER: Placebo - water|OTHER: Sports drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: LMB-9 Immunotoxin in Treating Patients With Advanced Colon, Breast, Non-small Cell Lung, Bladder, Pancreatic, or Ovarian Cancer
Status: COMPLETED
Conditions: Bladder Cancer|Breast Cancer|Colorectal Cancer|Lung Cancer|Ovarian Cancer|Pancreatic Cancer
Interventions: BIOLOGICAL: LMB-9 immunotoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sodium Oxybate in Spasmodic Dysphonia and Voice Tremor
Status: ACTIVE_NOT_RECRUITING
Conditions: Spasmodic Dysphonia|Voice Tremor
Interventions: DRUG: Sodium Oxybate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cerebral Oximetry and Anesthetic Technique
Status: COMPLETED
Conditions: Disorder of Hip Joint
Interventions: OTHER: general anesthesia|OTHER: spinal anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Post-Market Study of Robotic-Arm Assisted Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Total Knee Arthroplasty using Manual Instrumentation|DEVICE: Total Knee Arthroplasty using Robotic Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Physical Activity Program for Female Nursing Home Residents at Risk of Osteoporosis
Status: UNKNOWN
Conditions: Osteoporosis
Interventions: COMBINATION_PRODUCT: Physical activity and education intervention|BEHAVIORAL: Education intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cognitive-Behavioural Therapy (CBT) for Adult Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: OTHER: CBT plus treatment as usual|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MK-0518 Intensification And HDAC Inhibition In Depletion Of Resting CD4+ T Cell HIV Infection
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: Raltegravir; valproic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Molnupiravir (MK-4482; MOV) in Participants With Severe Renal Impairment (MK-4482-003)
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Molnupiravir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tapentadol IR vs Oxycodone IR vs Placebo in Acute Pain From Vertebral Compression Fracture Associated With Osteoporosis
Status: COMPLETED
Conditions: Back Pain
Interventions: DRUG: oxycodone IR|DRUG: placebo|DRUG: tapentadol IR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screening for GDM in Women With PCOS and Controls
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Gestational Diabetes Mellitus
Interventions: OTHER: OGTT by randomization|OTHER: OGTT by indication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of the Efficacy and Safety of Ulipristal Acetate Intermittent Treatment for Abnormal Uterine Bleeding Associated With Leiomyomas
Status: COMPLETED
Conditions: Leiomyoma|Uterine Hemorrhage
Interventions: DRUG: Ulipristal acetate (UPA)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Cabozantinib in Combination With Abiraterone in Chemotherapy-Naïve Subjects With Bone-Metastatic Castration-Resistant Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer|Castration Resistant Prostate Cancer|Prostatic Neoplasms
Interventions: DRUG: cabozantinib|DRUG: abiraterone|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TandemHeart to Reduce Infarct Size (TRIS Trial)
Status: WITHDRAWN
Conditions: Acute Myocardial Infarction
Interventions: DEVICE: TandemHeart System|PROCEDURE: Percutaneous coronary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-CTLA-4 Human Monoclonal Antibody CP-675,206 in Patients With Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Hepatitis C Virus Chronic Infection
Interventions: BIOLOGICAL: CP 675,206
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Glycomacropeptide Versus Amino Acid Diet for Management of Phenylketonuria
Status: COMPLETED
Conditions: Phenylketonuria
Interventions: OTHER: GMP Diet/GMP Medical Foods|OTHER: AA Diet/AA Medical Foods
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COLO-DETECT: Can an Artificial Intelligence Device Increase Detection of Polyps During Colonoscopy?
Status: COMPLETED
Conditions: Colonic Polyp|Colorectal Polyp|Colorectal Adenoma|Colorectal Adenomatous Polyp|Colorectal SSA|Sessile Serrated Adenoma|Sessile Colonic Polyp
Interventions: DEVICE: GI Genius-assisted diagnostic colonoscopy|DIAGNOSTIC_TEST: Diagnostic Colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Heart & Mind Study
Status: COMPLETED
Conditions: Hypertension|Cognitive Decline|Vascular Cognitive Impairment
Interventions: BEHAVIORAL: High-intensity Interval Training (HIT)|BEHAVIORAL: Moderate-intensity Continuous Training (MCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Role of Procedural Videos in Teaching the Surgery Residents
Status: COMPLETED
Conditions: Educational Techniques|Surgical Procedure, Unspecified
Interventions: OTHER: Procedural Videos|OTHER: No procedural videos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Tadalafil and Lenalidomide Maintenance With or Without Activated Marrow Infiltrating Lymphocytes (MILs) in High Risk Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: aMIL|DRUG: No aMIL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19: A Study to Evaluate Safety, Reactogenicity and Immunogenicity of the SARS-CoV-2 mRNA Vaccine CVnCoV in Adults With Co-morbidities
Status: TERMINATED
Conditions: Coronavirus|Covid19|SARS-CoV-2|Severe Acute Respiratory Syndrome
Interventions: BIOLOGICAL: CVnCoV Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Optic Nerve Sheath Diameter (ONSD) With the Raised PCO2 and Internal Jugular Venous Occlusion
Status: COMPLETED
Conditions: Elevated Intracranial Pressure (ICP)
Interventions: OTHER: Ultrasonographic of the optic nerve sheath diameter|OTHER: RespirAct™|OTHER: Neck collar
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PROTECT-2: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function
Status: COMPLETED
Conditions: Heart Failure, Congestive
Interventions: DRUG: rolofylline|DRUG: Comparator: Placebo (unspecified)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Predictive Biomarkers Including miRNA-based Tumor Signatures in Diffuse Large B Cell Lymphoma (R/R DLBCL) (MIMOSA)
Status: NOT_YET_RECRUITING
Conditions: Diffuse Large B Cell Lymphoma|Relapsed Non-Hodgkin Lymphoma
Interventions: OTHER: no intervention (observational study)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Incidence and Prevention of Hypothermia in Newborns Bonding During Caesarean Section
Status: COMPLETED
Conditions: Thermoregulation Impairment|Hypothermia|Postoperative Shivering
Interventions: PROCEDURE: Forced-air warming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Aflibercept for Treatment of Polypoidal Choroidal Vasculopathy (PCV)
Status: COMPLETED
Conditions: Symtomatic Macular Polypoidal Choroidal Vasculopathy
Interventions: BIOLOGICAL: Intravitreous aflibercept injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Maintenance Dosing vs Loading Dosing Upon Restarting Warfarin Therapy: A Prospective Randomized Trial
Status: COMPLETED
Conditions: Anticoagulation
Interventions: DRUG: warfarin|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Adjuvant Enzalutamide for the Treatment of Early Stage AR (+) Triple Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Early Stage|Triple Negative Breast Cancer
Interventions: DRUG: Enzalutamide|BEHAVIORAL: assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REDUCE Trial: Perineural Dexamethasone on Scalp Nerve Blocks
Status: COMPLETED
Conditions: Postoperative Pain|Craniotomy|Dexamethasone|Scalp Nerve Blocks
Interventions: DRUG: Bupivacaine|DRUG: Dexamethasone combined with bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of New Ambroxol Hardboiled Lozenges in Acute Pharyngitis
Status: COMPLETED
Conditions: Pharyngitis
Interventions: DRUG: ambroxol BIH1526|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Dexmedetomidine for Adult Patients Undergoing Phacoemulsification Cataract Surgery
Status: RECRUITING
Conditions: Cataract|Preoperative Sedation
Interventions: DRUG: Dextrometropine and 0.9% sodium chloride solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Myocardial Micro-damage in Relation to Active and Passive Fixation Pacemaker Electrodes
Status: COMPLETED
Conditions: Bradyarrhythmia
Interventions: DEVICE: Pacemaker implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: HAIC Combined With Second-line "Target Immunity" for HCC With TACE Standard Treatment Low Response or Failure
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: Hepatic Artery Infusion Chemotherapy|PROCEDURE: Transarterial Chemoembolization|DRUG: Regorafenib|DRUG: Immune Checkpoint Inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of GSK Biologicals' Pandemic Influenza Candidate Vaccine (H1N1) (GSK2340272A)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Pandemic influenza vaccine GSK2340272A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Correlation Between Circulating Biomarkers of Organs Damage and Intraoperative Hypotension Management
Status: COMPLETED
Conditions: Hypotension|Brain Injuries|Renal Failure|Endothelial Dysfunction
Interventions: DEVICE: Flo TracIQ with HPI software
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Eradication of H. Pylori Infection With Moxifloxacin
Status: COMPLETED
Conditions: Helicobacter Pylori Infection|Helicobacter Pylori Infection, Susceptibility to
Interventions: DRUG: Sequential Regimen: Levofloxacin 500 mg BID, Amoxicillin 1 gm BID, omeprazole 20 mg BID for first five days followed by Levofloxacin 500 mgBID, Tinidazole 500 mg BID, Omeprazole 20 mg BID|DRUG: Triple Regimen: Moxifloxacin 400mg OD, Amoxicillin 1 gm BID, Omeprazole 20mgBID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarker for the Early Diagnosis and Monitoring in Tyrosinemia Type 1 (BioTyrosin)
Status: WITHDRAWN
Conditions: Tyrosinosis|Hepatorenal Tyrosinemia|Fumarylacetoacetase Deficiency|Fah Deficiency|Metabolic Disorders
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: First-in-Human Dose Escalation Study of AFM28 in Patients With Relapsed/Refractory Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: AFM28
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study in Healthy Adults Who Sometimes Take Drugs for Pleasure to Investigate the Safety and Tolerability of GRT0151Y and to Find Out Which Single Dose of the Compound is Maximally Tolerated
Status: COMPLETED
Conditions: Pain|Acute Pain|Chronic Pain
Interventions: DRUG: GRT0151Y dose escalation|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RISE: A Remote Study of Insomnia Treatment in Crohn's Disease
Status: RECRUITING
Conditions: Insomnia|Crohn Disease
Interventions: BEHAVIORAL: Behavioral Treatment|BEHAVIORAL: Sleep Education Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Dietary Fiber on Affective Processes
Status: COMPLETED
Conditions: Emotions|Stress|Fear
Interventions: DIETARY_SUPPLEMENT: Dietary fiber|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Placebo-Controlled, Phase I, Pilot Clinical Trial to Evaluate the Safety and Immunogenicity of ENV 2-3, a Yeast-Derived Recombinant Envelope Protein of Human Immunodeficiency Virus-1, in Combination With MTP-PE/MF59 in Individuals With HIV Infection (Placebo Patients Receive MF59 Emulsion Only)
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: MTP-PE/MF59|BIOLOGICAL: Env 2-3
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT