pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Supplementing L-citrulline to Overweight Late Asthma oNset Phenotypes
Status: RECRUITING
Conditions: Asthma|Obesity
Interventions: DRUG: L-ctirulline|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Genuine vs Sham Acupuncture and Communication Type on Relaxation
Status: COMPLETED
Conditions: Healthy
Interventions: PROCEDURE: acupuncture|PROCEDURE: sham acupuncture|PROCEDURE: positive communication|PROCEDURE: neutral communication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Use of Spinal Epimorph in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Post-operative Pain|Osteoarthritis
Interventions: DRUG: Epimorph|DRUG: Spinal analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interventional Neuromodulation in Fibromyalgia
Status: RECRUITING
Conditions: Neuromodulation and Sleep Disorders
Interventions: DEVICE: repetitive transcranial magnetic stimulation active stimulation|DEVICE: repetitive transcranial magnetic stimulation sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Assist-Knee: Energy-Harvesting Knee Prosthesis
Status: COMPLETED
Conditions: Transfemoral Amputation|Artificial Limbs
Interventions: DEVICE: Assist-Knee|DEVICE: Habitual Prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study to Evaluate the Efficacy and Safety of 2 Doses of EYE103 Compared With Ranibizumab (0.5 mg) in Participants With DME
Status: RECRUITING
Conditions: Diabetic Macular Edema (DME)
Interventions: DRUG: Ranibizumab|DRUG: EYE103
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Brain Activity Changes After a Behavior Change Weight Loss Intervention
Status: COMPLETED
Conditions: Obesity|Behavior, Health|Weight Loss
Interventions: BEHAVIORAL: Noom Healthy Weight; mobile behavior change program for weight loss.|OTHER: Matched Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Banlangen Granules Anti-seasonal Influenza Study
Status: UNKNOWN
Conditions: Influenza
Interventions: DRUG: placebo of oseltamivir phosphate|DRUG: oseltamivir phosphate|DRUG: Banlangen (Radix Isatidis) granules|DRUG: placebo of Banlangen(Radix Isatidis) granules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Growth Hormone and Intrahepatic Lipid Content in Patients With Nonalcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Nonalcoholic Fatty Liver Disease (NAFLD)
Interventions: DRUG: Growth hormone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: General Versus Regional Anesthesia and Postoperative Sleep Quality
Status: RECRUITING
Conditions: Anesthesia|Surgery|Sleep Disturbance|Sleep Disorder|Sleep Fragmentation|Sleep Disorders, Circadian Rhythm|Sleep Initiation and Maintenance Disorders|Sleep
Interventions: PROCEDURE: general anesthesia|PROCEDURE: regional anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: N-acetylcysteine Treatment of Alcohol Use Disorder In Veterans With TBI
Status: COMPLETED
Conditions: Traumatic Brain Injury (TBI)|Hazardous and Harmful Alcohol Use
Interventions: BEHAVIORAL: Medical Management Counseling|DRUG: N-acetylcysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety & Efficacy of Genakumab in Patients With Frequent Flares
Status: RECRUITING
Conditions: Acute Gout
Interventions: DRUG: genakumab|DRUG: placebo for Diprospan|DRUG: placebo for genakumab|DRUG: Diprospan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Compare the Effects of Non-nutritive Sweeteners Intake in Woman With Insulin Resistance
Status: COMPLETED
Conditions: Insulin Resistance|Hyperinsulinism
Interventions: OTHER: Intervention ingest a 5000 mg of D-tagatose|OTHER: Intervention ingest a 15,3 mg of stevia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: A Study to Assess the Reaction of Body for Four Different Formulations of AZD9977 (Part A) and Influence of Food and Lower Dose of a Selected Formulation (Part B) in Healthy Male Subjects
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Treatment A|DRUG: Treatment B|DRUG: Treatment C|DRUG: Treatment D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of ASP1517 After Intermittent Oral Dosing in Dialysis Chronic Kidney Disease Patients With Anemia Compared With Darbepoetin as a Reference Drug
Status: COMPLETED
Conditions: Renal Anemia Associated With Chronic Renal Failure (CRF)
Interventions: DRUG: roxadustat|DRUG: darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gastrointestinal Behavior of Posaconazol in Healthy Volunteers
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Suspension Fasted State|DRUG: Suspension Fed State|DRUG: Solution Fasted State|DRUG: Solution Fed State
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Evaluating Safety, Tolerability and Clinical Activity of GSK2857916 in Combination With Pembrolizumab in Subjects With Relapsed/Refractory Multiple Myeloma (RRMM)
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: belantamab mafodotin|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Busulfan, Etoposide, Cytarabine, and Melphalan (BuEAM) Conditioning for Autologous Stem Cell Transplantation (ASCT) to Treat B Cell Lymphoma Except for Diffuse Large B Cell Lymphoma
Status: UNKNOWN
Conditions: Non-Hodgkin Lymphoma
Interventions: DRUG: Busulfan, etoposide, cytarabine, and melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: K-Basket, Avelumab, Biomarker-driven, Advanced Solid Tumor
Status: UNKNOWN
Conditions: PD-L1 Positive Mutation Tumor|EBV Positive Mutation Tumor|MSI-H Mutation Tumor|POLE/POLD1 Mutation Tumor
Interventions: DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sub Occipital Muscle Inhibition Versus Slump Stretch Position in Short Hamstring Syndrome Subjects
Status: COMPLETED
Conditions: Musculoskeletal Diseases or Conditions
Interventions: OTHER: Suboccipital muscle inhibition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Meal Order on Postprandial Cardiometabolic Risk Markers
Status: COMPLETED
Conditions: Metabolic Syndrome X|Insulin Resistance|Hyperinsulinism|Glucose Metabolism Disorders|Metabolic Diseases
Interventions: OTHER: Standard meal, bread/butter as starter|OTHER: Standard meal with soup as starter|OTHER: Standard meal with cheese as starter|OTHER: Standard meal with salad as starter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Metformin Plus Oligomeric Procyanidin Complex for Pharmacologic Manipulation of AGE (Advanced Glycation Endproducts) Levels in Prostate Cancer Patients
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: DRUG: Metformin|DRUG: Oligomeric Procyanidin Complex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trimodal Prehabilitation for Cystectomy Patients to Enhance Post-operative Care
Status: UNKNOWN
Conditions: Bladder Cancer|Nutrition Aspect of Cancer
Interventions: COMBINATION_PRODUCT: Trimodal Prehab & ERP|OTHER: No Prehab; ERP Alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation the Feasibility and Effects of Kinect-based Computer Games as UE Training Tool in Cerebral Palsy Children
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DEVICE: Kinect|OTHER: Traditional OT(30 Mins)|OTHER: Traditional OT(60 Mins)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Nocturnal Non-invasive Ventilation on Energy Expenditure in Patients With Severe Chronic Obstructive Pulmonary Disease
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease|Pulmonary Rehabilitation|Non-invasive Ventilation|Energy Expenditure
Interventions: DEVICE: nocturnal non-invasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Small Intestine Bacterial Overgrowth Study Pilot
Status: UNKNOWN
Conditions: Systemic Sclerosis|Small Intestinal Bacterial Overgrowth
Interventions: OTHER: Treatment Protocol|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of XmAb®662 as Monotherapy or in Combination With Pembrolizumab in Advanced Solid Tumors
Status: TERMINATED
Conditions: Solid Tumors
Interventions: BIOLOGICAL: XmAb662|BIOLOGICAL: Keytruda® (pembrolizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Rehabilitation Exercise Program for Community-based Spinal Cord Injury Patients
Status: COMPLETED
Conditions: Spinal Cord Injuries|Rehabilitation|Exercise Program
Interventions: BEHAVIORAL: Structured rehabilitation exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Relamorelin in Participants With Diabetic Gastroparesis Study 02
Status: TERMINATED
Conditions: Gastroparesis|Diabetes Mellitus
Interventions: DRUG: Placebo|DRUG: Relamorelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Septal Positioning of Ventricular Implanted Cardioverter Defibrillator (ICD) Leads
Status: COMPLETED
Conditions: Ventricular Tachycardia|Ventricular Fibrillation
Interventions: DEVICE: Device Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Propofol or Midazolam Compare to Placebo for Preoperative Medication
Status: COMPLETED
Conditions: Elective Orthopedic Surgery
Interventions: DRUG: Midazolam|DRUG: Propofol|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Exploring Mechanisms and Morphology of QT Interval Prolongation
Status: COMPLETED
Conditions: Long Qt Syndrome 1-2|Sudden Cardiac Death
Interventions: DRUG: Beta Blockers|DRUG: Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Valsartan/Amlodipine Compared to Amlodipine in Patients With Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Valsartan 160 mg capsules|DRUG: Amlodipine 5 mg capsules|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial on the Safety and Efficacy of MLS-101 in Patients With Uncontrolled Hypertension
Status: COMPLETED
Conditions: Hypertension, Renal
Interventions: DRUG: MLS-101 (Part I)|OTHER: Placebo (Part I)|OTHER: Placebo (Part II)|DRUG: MLS-101 (Part II)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Laser Acupuncture on Health Promotion of Sub-health People
Status: UNKNOWN
Conditions: Suboptimal Health Status
Interventions: DEVICE: Low level laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Using Cannabidiol to Treat Diabetic Peripheral Neuropathy of the Feet
Status: UNKNOWN
Conditions: Diabetic Peripheral Neuropathic Pain
Interventions: DRUG: CBD|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1B Study to Investigate the Safety and Preliminary Efficacy for the Combination of Dasatinib Plus Nivolumab in Patients With Chronic Myeloid Leukemia
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Dasatinib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Assessment of Coronary MR Angiography Vs Coronary Multislice CT After Coronary Artery Reimplantation in Children and Young Adults.
Status: UNKNOWN
Conditions: Myocardial Ischemia
Interventions: PROCEDURE: magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Integrative Approach to Improve Child Outcomes Through Research-based Parent and Teacher Interventions
Status: COMPLETED
Conditions: Growth & Development
Interventions: BEHAVIORAL: PALS and|BEHAVIORAL: BEECH|BEHAVIORAL: Control condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of the T-Control® Catheter Compared to the Foley-type Catheter in Patients With Long-term Catheterization
Status: NOT_YET_RECRUITING
Conditions: Catheter; Infection (Indwelling Catheter)|Quality of Life|Catheter Related Complication
Interventions: DEVICE: T-Control® catheter|DEVICE: Foley-type catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Noninvasive Dual-mode Stimulation Therapy for Neurorehabilitation in Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: DEVICE: High-frequency rTMS on left DLPFC+anodal tDCS on right DLPFC|DEVICE: High-frequency rTMS on left DLPFC+cathodal tDCS on right DLPFC|DEVICE: High-frequency rTMS on left DLPFC+sham tDCS on right DLPFC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease
Status: RECRUITING
Conditions: Obesity|Cardiovascular Diseases
Interventions: DRUG: Retatrutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of CD30 CAR for Relapsed/Refractory CD30+ HL and CD30+ NHL
Status: RECRUITING
Conditions: Lymphoma|Lymphoma, Non-Hodgkin|Immune System Diseases|Immunoproliferative Disorders|Lymphatic Diseases|Lymphoproliferative Disorders|Neoplasms|Neoplasms by Histologic Type
Interventions: BIOLOGICAL: ATLCAR.CD30 cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Fraction Stereotactic Body Radiation Therapy After Surgery in Treating Patients With Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Lung Non-Small Cell Carcinoma|Positive Surgical Margin|Resected Mass|Stage III Lung Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|Stage IIIC Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Velcade® in Patients Stage IIIB OR IV Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: STAGE IIIB OR IV NON-SMALL CELL LUNG CANCER
Interventions: DRUG: Bortezomid (VELCADE®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Next Generation Sequence Target-Directed Therapy in Treating Patients With Cancer
Status: COMPLETED
Conditions: Malignant Neoplasm
Interventions: OTHER: cytology specimen collection procedure|DRUG: targeted therapy|PROCEDURE: therapeutic procedure|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postpartum Glucose Tolerance With Levonorgesterel IUD Use in Women With Recent Gestational Diabetes
Status: COMPLETED
Conditions: Gestational Diabetes|Glucose Intolerance|Type 2 Diabetes|Intrauterine Contraception
Interventions: DEVICE: Mirena (Levonorgestrel IUD)|DEVICE: Paragard (Copper IUD ) or Tubal Ligation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Computed Tomography-Guided Stereotactic Adaptive Radiotherapy (CT-STAR) for the Treatment of Central and Ultra-Central Early-Stage Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Early Stage Non-small Cell Lung Cancer|Non-small Cell Lung Cancer
Interventions: RADIATION: Computed tomography-guided stereotactic adaptive radiotherapy|DEVICE: ETHOS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Symptom Identification and Management in Patients With Hematological Malignancy During Follow-up Care
Status: COMPLETED
Conditions: Hematologic Malignancy
Interventions: OTHER: HM-PRO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety of Tiotropium + Olodaterol in Chronic Obstructive Pulmonary Disease (COPD) Patients in Taiwan: a Non-interventional Study Based on the Taiwan National Health Insurance (NHI) Data
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium+Olodaterol|DEVICE: Spiolto Respimat|DRUG: Long-acting muscarinic antagonists (LAMAs)|DRUG: Long-acting β2-agonists (LABAs)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Atomoxetine in Children With Recent Diagnosis of Attention-Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Atomoxetine Hydrochloride|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Physical Exercise Training in Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: COPD|Exercise|Resistance Training
Interventions: BEHAVIORAL: Resistance training|BEHAVIORAL: Endurance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Low-Dose Fractionated Radiotherapy in Patients With Locally Advanced Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Carcinoma Non-resectable|Metastatic Pancreatic Cancer
Interventions: DRUG: gemcitabine|DRUG: Erlotinib|RADIATION: low dose fractionated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes of Urinary Incontinence Treatment in Primary Care: APP Co-Management and Electronic Consult
Status: NOT_YET_RECRUITING
Conditions: Urinary Incontinence
Interventions: OTHER: APP Co-management|OTHER: E-consult
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy Study of Pioglitazone and Metformin and Association Between Pioglitazone Response and Peroxisome Proliferator-activated Receptor Gamma Gene Variants in Bangladeshi Type 2 Diabetes Mellitus Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Pioglitazone hydrochloride|DRUG: Metformin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nasal Irrigation in Infants With Bronchiolitis.
Status: COMPLETED
Conditions: Bronchiolitis
Interventions: DRUG: Isotonic solution (NaCl 0.9%)|DRUG: Hypertonic solution (NaCl 3%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Moderato System: A Double-Blind Randomized Trial Ver 1.1
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension Resistant to Conventional Therapy|Bradycardia|Atrioventricular Block
Interventions: DEVICE: PHC ON|DEVICE: PHC OFF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Unrelated Cord Blood Transplantation
Status: TERMINATED
Conditions: Leukemia, Myeloid, Acute|Myelodysplastic Syndromes|Leukemia, Lymphoblastic, Acute|Lymphoma, Non-Hodgkin|Hodgkin Disease|Chronic Lymphocytic Leukemia
Interventions: DRUG: Thiotepa|DRUG: Fludarabine|DRUG: Intravenous busulphan|DRUG: Thymoglobulin|DRUG: Ciclosporin|DRUG: Mycophenolate mofetil (MMF)|DRUG: Fludarabine|DRUG: Cyclophosphamide|RADIATION: Radiotherapy|DRUG: Thymoglobulin|DRUG: Ciclosporin|DRUG: Mycophenolate mofetil (MMF)|DRUG: Fludarabine|DRUG: Melphalan|DRUG: Thymoglobulin|DRUG: Ciclosporin|DRUG: Mycophenolate mofetil (MMF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Interventional Pulmonology, Microbiota and Immune Response in the Patient With Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DIAGNOSTIC_TEST: Transbronchial forceps biopsy|DIAGNOSTIC_TEST: Transbronchial forceps biopsy+Transbronchial cryobiopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Vonoprazan Fumarate in Combination With Amoxicillin for the First-line Eradication of Helicobacter Pylori -- a Multicenter, Randomized, Parallel Controlled Study
Status: UNKNOWN
Conditions: Helicobacter Pylori Eradication Rate
Interventions: DRUG: vonoprazan fumarate + amoxicillin|DRUG: Esomeprazole +Amoxicillin+Clarithromycin+Bismuth potassium citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Potential Benefits of Dietary Advices Alone or Associated to Nutraceutical Food Supplements Argan Oil, VSL#3 Probiotic Blend, 5203-L Fruit Extract Terpene
Status: COMPLETED
Conditions: Healthy Elderly People
Interventions: DIETARY_SUPPLEMENT: VSL#3® probiotic blend|DIETARY_SUPPLEMENT: AISA-5203-L fruit extracted terpene|DIETARY_SUPPLEMENT: Argan oil|BEHAVIORAL: Optimal Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: SCREENS: Sleep, Circadian Rhythms, and Electronics in the EveNing Study
Status: NOT_YET_RECRUITING
Conditions: Sleep|Circadian Rhythm|Executive Function|Emotion Regulation
Interventions: BEHAVIORAL: no screen control with dim light and calming activities|BEHAVIORAL: unfiltered Bright tablet screen|BEHAVIORAL: Filtered dim tablet screen|BEHAVIORAL: Exciting content|BEHAVIORAL: Calming Content
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Lateral Ridge Augmentation Using Autogenous Bone Blocks or Xenogenic Bone Block Grafts Loaded With Recombinant Human Bone Morphogenic Protein 2
Status: COMPLETED
Conditions: Missing Teeth
Interventions: DEVICE: Autogenous bone graft|DRUG: InductOs|PROCEDURE: Augmentation surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: HIV Risk Reduction and Drug Abuse Treatment in Malaysia
Status: COMPLETED
Conditions: Opiate Dependence
Interventions: DRUG: Buprenorphine/Subutex|DRUG: Naltrexone|PROCEDURE: Drug counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Leptomeningeal Neoplasm|Metastatic Lung Non-Small Cell Carcinoma|Metastatic Malignant Neoplasm in the Brain|Recurrent Lung Non-Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: DRUG: Sapanisertib|DRUG: Telaglenastat Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-fat Overfeeding, Hepatokines and Appetite Regulation
Status: COMPLETED
Conditions: Insulin Resistance|Type2 Diabetes Mellitus|Non-Alcoholic Fatty Liver Disease|Obesity
Interventions: DIETARY_SUPPLEMENT: High-fat diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke
Status: COMPLETED
Conditions: Cerebral Infarction
Interventions: OTHER: Usual care patients in neurology department|BIOLOGICAL: blood and urines sampling|PROCEDURE: Psychiatric evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: FitEx for Endometrial Cancer Survivors: Initial Efficacy
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Cancer|Obesity|Sedentary Behavior|Quality of Life|Survivorship
Interventions: BEHAVIORAL: Self-monitoring|BEHAVIORAL: Group-dynamics|BEHAVIORAL: Weekly virtual sessions- Standard|BEHAVIORAL: Newsletters- Standard|BEHAVIORAL: Newsletters- Yoga|BEHAVIORAL: Weekly virtual sessions- Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study)
Status: RECRUITING
Conditions: Dyslipidemias|Cardiovascular Diseases|HIV Infections
Interventions: DRUG: Alirocumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Phase I/II Prospective, Open Nonrandomized for Treatmen of Postoperative Air Leak After Lung Resection in High Risk Patients Through the Administration of Mesenchymal Autologous Cells
Status: UNKNOWN
Conditions: Postoperative Air Leaks in Risk Patients
Interventions: BIOLOGICAL: Implantation of autologous mesenchymal stem cells (CSM) expanded "in vitro" and administered directly into the lung suture line
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Non-invasive Pelvic Floor Muscle Trainer for Treatment of Stress Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence|Urinary Incontinence|Pelvic Floor Disorders
Interventions: DEVICE: Pelex Upp
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Dorzolamide as an Adjuvant After Focal Photocoagulation in Clinically Significant Macular Edema
Status: UNKNOWN
Conditions: Diabetic Retinopathy|Diabetic Macular Edema
Interventions: DRUG: Dorzolamide hydrochloride (2%)|DRUG: Placebo Sodium hyaluronate 4mg
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Biphasic Insulin Aspart 50 on Blood Glucose Control in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart 30|DRUG: metformin|DRUG: biphasic insulin aspart 50
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Motorised Prosthetic Knee
Status: NOT_YET_RECRUITING
Conditions: Lower Limb Amputation Above Knee (Injury)
Interventions: DEVICE: Current prosthesis|DEVICE: Active Prosthesis (PowerKnee)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Botulinum Toxin Type A for the Treatment of Patients With Idiopathic Overactive Bladder With Urinary Incontinence
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: BIOLOGICAL: onabotulinumtoxinA|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nerve Growth Factor Encapsulated With 2-methacryloyloxyethyl Phosphorylcholine Nanocapsules in the Treatment of Amyotrophic Lateral Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Nerve Growth Factor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Indoor Plants on Cardiopulmonary System
Status: COMPLETED
Conditions: Cardiopulmonary
Interventions: OTHER: Plants placed in an office environment|OTHER: Devoid of any plant presence in an office environment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: DEXTENZA for the Treatment of Pain and Inflammation Following Surgical Trabeculectomy and Ahmed Valve Procedures
Status: UNKNOWN
Conditions: Glaucoma Following Surgery
Interventions: DRUG: DEXTENZA|DRUG: Topical Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Bryostatin in Moderately Severe to Severe Alzheimer's Disease Subjects Not On Memantine
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Bryostatin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Trastuzumab in Combination With TS-ONE & Cisplatin in First-line Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: Trastuzumab in Combination with TS-ONE and cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telephone Assessment and Skill-Building Kit (TASK): A New Program for Family Caregivers of Stroke Survivors
Status: COMPLETED
Conditions: Family Caregivers of Stroke Survivors|Stroke
Interventions: BEHAVIORAL: TASK intervention|BEHAVIORAL: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Metformin's Effect on Drug Metabolism in Patients With Type 2 Diabetes
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Metformin|DRUG: Caffeine|DRUG: Efavirenz|DRUG: Losartan|DRUG: Omeprazol|DRUG: Metoprolol|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Immunogenicity of the Malaria Vaccine, R21/MatrixM, in Healthy Thai Adults
Status: COMPLETED
Conditions: Malaria,Falciparum
Interventions: BIOLOGICAL: R21/Matrix-M vaccination|DRUG: DHA-PIP|DRUG: PQ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Novel E-cigarette Constituents on Adults TCORS 3.0
Status: NOT_YET_RECRUITING
Conditions: Nicotine Use Disorder
Interventions: OTHER: E-liquid coolant (No WS-3) for non-menthol (1)|OTHER: E-liquid coolant (No WS-3) for low menthol (1)|OTHER: E-liquid coolant (No WS-3) for high menthol (1)|OTHER: E-liquid coolant (Low WS-3) for non-menthol (2)|OTHER: E-liquid coolant (Low WS-3) for low menthol (2)|OTHER: E-liquid coolant (Low WS-3) for high menthol (2)|OTHER: E-liquid coolant (High WS-3) for non-menthol (3)|OTHER: E-liquid coolant (High WS-3) for low menthol (3)|OTHER: E-liquid coolant (High WS-3) for high menthol (3)|OTHER: E-liquid coolant (Low WS-23) for non-menthol (4)|OTHER: E-liquid coolant (Low WS-23) for low menthol (4)|OTHER: E-liquid coolant (Low WS-23) for high menthol (4)|OTHER: E-liquid coolant (High WS-23) for non-menthol (5)|OTHER: E-liquid coolant (High WS-23) for low menthol (5)|OTHER: E-liquid coolant (High WS-23) for high menthol (5)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Phase 3 Study With Ciprofloxacin Dispersion for Inhalation in Non-CF Bronchiectasis (ORBIT-4)
Status: COMPLETED
Conditions: Non Cystic Fibrosis Bronchiectasis
Interventions: DRUG: Ciprofloxacin dispersion for inhalation|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rapamycin With Grapefruit Juice for Advanced Malignancies
Status: COMPLETED
Conditions: Tumors|Neoplasm Metastasis
Interventions: DRUG: Rapamycin (sirolimus)|OTHER: Grapefruit Juice
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial to Assess the Effect of L-carnitine in Patients With Diabetic Peripheral Neuropathy to Relief Pain and Symptom Improvement
Status: UNKNOWN
Conditions: Patient Compliance
Interventions: DRUG: Levocarnitine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sientra Sponsored Silimed Gel-Filled Breast Implant Core Clinical Study
Status: COMPLETED
Conditions: Breast Augmentation|Breast Reconstruction|Breast Revision
Interventions: DEVICE: Silimed Gel-Filled Mammary Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dosing Strategies for de Novo Once-daily Extended Release Tacrolimus (LCPT) in Kidney Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplant
Interventions: DRUG: Tacrolimus Extended Release Oral Tablet [Envarsus] 0.13mg/kg/day initiated within post-operative day 3 after kidney transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sedentary Behavior Interrupted Randomized Controlled Trial (P2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Sedentary Lifestyle
Interventions: BEHAVIORAL: Health Coaching|DEVICE: activPAL inclinometer|OTHER: Tools to Prompt Standing or Prompt Sit-to-Stand Transitions.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of D3S 001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.G12C Mutation
Status: RECRUITING
Conditions: KRAS P.G12C
Interventions: DRUG: D3S-001|DRUG: Pembrolizumab|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Pemetrexed|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiac Dysfunction in Obstructive Sleep Apnea Patients: Prevalence of and Effect of nCPAP
Status: COMPLETED
Conditions: Sleep Apnea
Interventions: DEVICE: Nasal continuous positive airway pressure (nCPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endo-perio Lesion's Treatment With Using Diode Laser 940nm
Status: UNKNOWN
Conditions: Periodontitis|Endodontic Inflammation
Interventions: DEVICE: Endo-perio therapy with laser 940nm|DEVICE: Endo-perio therapy without laser 940nm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decadron as Adjuvant in Femoral Nerve Blocks in Knee Arthroscopy
Status: COMPLETED
Conditions: Knee Injury
Interventions: DRUG: Dexamethasone|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Safety and Clinical Efficacy of AZVUDINE in Initial Stage COVID-19 Patients (SARS-CoV-2 Infected)
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: AZVUDINE|DRUG: AZVUDINE placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Trial of Clofarabine in Combo w/ HD Etoposide & Cyclophosphamide and APBSCT for Pts w/ High-Risk or Refractory NHL
Status: COMPLETED
Conditions: Non Hodgkin's Lymphoma
Interventions: DRUG: clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare Propofol to Fentanyl and Midazolam for Colonoscopy
Status: COMPLETED
Conditions: Colon Cancer|Rectal Cancer|Colonic Diverticulosis
Interventions: DRUG: Fentanyl|DRUG: Propofol|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Constitutive Study of a Serum Bank and Plasma Bank of Healthy Subjects Comparators to Dialysis Subjects (SPSSCD)
Status: COMPLETED
Conditions: Serum Bank|Plasma Bank|Dialysis
Interventions: BIOLOGICAL: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Tranexamic Acid in Total Knee Replacement
Status: COMPLETED
Conditions: Osteo Arthritis Knee
Interventions: DRUG: Tranexamic Acid|DRUG: Tranexamic Acid|DRUG: Tranexamic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colpopexy and Urinary Reduction Efforts (CARE) Protocol
Status: COMPLETED
Conditions: Urinary Incontinence, Stress|Uterine Prolapse|Vaginal Prolapse
Interventions: PROCEDURE: Burch urethropexy at time of sacrocolpopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Role of Altered Nutrient Partitioning in Food Reward
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: OTHER: Conditioned Stimulus + (CS+): Flavored beverage solution with 75 calories of sucrose|OTHER: Conditioned Stimulus - (CS-): Flavored beverage solution with sweetness-matched sucralose|OTHER: High-Fat Test Meal Inside a Metabolic Chamber|OTHER: High-Carbohydrate Test Meal Inside a Metabolic Chamber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study To Evaluate A Booster Dose Of Menacwy-tt Vaccine Administered 10 Years After Healthy Subjects Aged 11-17 Years Received Either Menacwy-tt Vaccine (Nimenrix(Registered)) Or Mencevax Acwy(Registered).
Status: COMPLETED
Conditions: Meningococcal ACWY Disease
Interventions: BIOLOGICAL: MenACWY-TT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Laparoscopic Versus Open Abdominal Aortic Aneurysm (AAA) Exclusion
Status: WITHDRAWN
Conditions: Infra and Juxtarenal Abdominal Aortic Aneurysms
Interventions: PROCEDURE: conventional surgery|PROCEDURE: laparoscopic AAA resection|PROCEDURE: laparoscopic stapler anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Single-blind RCT Comparing Smartphone vs. Paper-based HEP in Pelvic Floor PT
Status: COMPLETED
Conditions: Pelvic Floor Muscle Weakness
Interventions: BEHAVIORAL: A smartphone based application free to download from the google play and iphone store to provide auditory and visual cues and counting for number of perscribed pelvic floor muscle contractions|BEHAVIORAL: Paper-based home exercise program for pelvic floor muscle exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of BIBF 1120 in Patients With Advanced Gynaecological Malignancies
Status: COMPLETED
Conditions: Genital Neoplasms, Female
Interventions: DRUG: BIBF 1120|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Youth to Text or Telehealth for Engagement in HIV Care
Status: COMPLETED
Conditions: HIV/AIDS|Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)|Depression|Substance Use
Interventions: BEHAVIORAL: Counselor delivered telehealth intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Microbiome and Health Indicators in People With Obesity, Prediabetes and Type 2 Diabetes Undergoing a Lifestyle Intervention
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Obesity|PreDiabetes
Interventions: BEHAVIORAL: Non-intensive intervention|BEHAVIORAL: Intensive intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lymph Node Microenvironment Modifications in Patients With CLL Treated With Venetoclax-based Regimens
Status: NOT_YET_RECRUITING
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Anastrozole and Vandetanib (ZD6474) in Neoadjuvant Treatment of Postmenopausal Hormone Receptor-Positive Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Vandetanib|DRUG: Anastrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Randomized Study of Concurrent Chemo-radiotherapy vs Radiotherapy Alone to Local-advanced Small Cell Lung Cancer (SCLC)
Status: UNKNOWN
Conditions: Small Cell Lung Cancer
Interventions: OTHER: concurrent chemo-radiotherapy arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Cardiac Allograft Vasculopathy Using Rituximab (Rituxan) Therapy in Cardiac Transplantation
Status: TERMINATED
Conditions: Cardiac Allograft Vasculopathy|Heart Transplant Recipients
Interventions: BIOLOGICAL: Rituximab induction/conventional immunosuppression (tacrolimus, MMF, and steroid taper)|DRUG: Rituximab placebo/conventional immunosuppression (tacrolimus, MMF, and steroid taper)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION