pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: High-Intensity, Brief-Duration Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: filgrastim|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: leucovorin calcium|DRUG: mesna|DRUG: methotrexate|DRUG: therapeutic hydrocortisone|DRUG: vincristine sulfate|RADIATION: low-LET cobalt-60 gamma ray therapy|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of PF-06463922 An ALK/ROS1 Inhibitor In Patients With Advanced Non Small Cell Lung Cancer With Specific Molecular Alterations
Status: COMPLETED
Conditions: ALK-positive Non Small Cell Lung Cancer (NSCLC) and ROS1-positive NSCLC
Interventions: DRUG: PF-06463922|DRUG: Crizotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Youth Partners in Care for Suicide Prevention
Status: RECRUITING
Conditions: Suicide and Self-harm
Interventions: BEHAVIORAL: SAFETY-A within usual ED Care|BEHAVIORAL: Combined SAFETY-A within usual ED Care + CLASP Therapeutic Follow-Up Contacts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of BGB-290 in the Treatment of Metastatic HER2-Negative Breast Cancer Patients With BRCA Mutation in China
Status: COMPLETED
Conditions: HER2-negative Breast Cancer
Interventions: DRUG: BGB-290
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 12 Week Study to Assess Changes in Joint Inflammation Using Ultrasonography in Patients With Rheumatoid Arthritis (RA)
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Certolizumab Pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Multicenter Registry for Use of the MAXFRAME™ Multiaxial Correction System
Status: TERMINATED
Conditions: Limb Deformities Congenital|Limb Deformities Nos (Acquired)|Deformity of Bone
Interventions: DEVICE: DePuy Synthes MAXFRAMETM system
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study of an NTproBNP Guided Strategy of Cardioprotection
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiotoxicity|Toxicity Due to Chemotherapy|Breast Cancer|Lymphoma|Cardiomyopathies|Heart Failure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Usability and Ergonomic Evaluation of Self-Positioning System for Retinal Imaging
Status: COMPLETED
Conditions: AMD Population - Intermediate or Advanced AMD|DR Population- With or Without Diabetic Macular Edema
Interventions: DEVICE: PAF (Positioning And Fixation device)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: 3-day IV Antibiotic Treatment Versus 3-day IV Followed by 7-day Oral Antibiotic Treatment for AP in Children
Status: SUSPENDED
Conditions: Pyelonephritis Acute
Interventions: DRUG: IV Antibacterial Agents|DRUG: Orally antibacterial agents|PROCEDURE: Fecal/Rectal Swab|PROCEDURE: PCT assay|PROCEDURE: Renal scintigraphy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addressing Under-treatment and Health Equity in AS and MR Using an Integrated EHR Platform
Status: NOT_YET_RECRUITING
Conditions: Aortic Valve Stenosis|Mitral Regurgitation
Interventions: BEHAVIORAL: Automated alert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Tecovirimat in Non-hospitalized Patients With Monkeypox
Status: RECRUITING
Conditions: Monkeypox
Interventions: DRUG: Tecovirimat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Open Label Infliximab for the Induction and Maintenance of Mucosal Healing in Small Bowel Crohn's Disease Assessed Through Wireless Camera Endoscopy
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: Infliximab 5 mg/kg body weight infused over 2 hours
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-In-Human Study to Evaluate Safety, Tolerability, and PK of Intravenous ATB200 Alone and When Co-Administered With Oral AT2221
Status: COMPLETED
Conditions: Pompe Disease
Interventions: DRUG: ATB200|DRUG: AT2221
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Investigating NTLA-5001 in Subjects With Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukemia
Interventions: GENETIC: Arm 1: NTLA-5001|GENETIC: Arm 2: NTLA-5001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lutronic Infini and LaseMD Systems in Combination Treatment
Status: COMPLETED
Conditions: Face and Neck Wrinkles, Texture, Pigmentation
Interventions: DEVICE: Lutronic Infini System|DEVICE: Lutronic LaseMD System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety, Tolerability, PK & PD of Intravenous VX15/2503 in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: VX15/2503
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noradrenaline Infusion Versus Phenylephrine Infusion in Improving Serum Lactate Level in HIPEC
Status: COMPLETED
Conditions: Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
Interventions: DRUG: NORADRENALIN|DRUG: PHENYLEPHRINE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Randomised, Controlled, Open-Label, Multi-Centre Study to Evaluate the Efficacy of FeetMe® Home-Bases Rehabilitation Program in Comparison to Conventional Physiotherapy in Patients With Parkinson's Disease Using Connected Insoles
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease|Gait Disorders, Neurologic
Interventions: DEVICE: FeetMe rehabilitation|OTHER: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pilot Study: Rectus Sheath Blocks for Improving Abdominal Surgery Conditions
Status: TERMINATED
Conditions: Hernia|Pain, Postoperative|Abdominal Wall Relaxation After Rectus Sheath Block
Interventions: DRUG: Bupivacaine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: A Study of GEn-1124 in Subjects With Acute Respiratory Distress Syndrome (ARDS)
Status: RECRUITING
Conditions: Respiratory Distress Syndrome, Acute
Interventions: DRUG: GEn-1124|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Remimazolam for Sedation in ICU Patients Undergoing Mechanical Ventilation
Status: UNKNOWN
Conditions: Sedation
Interventions: DRUG: Remimazolam|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pazopanib and Paclitaxel as First-Line Treatment for Subjects With Unresectable Stage III and Stage IV Melanoma
Status: COMPLETED
Conditions: Stage III Melanoma|Stage IV Melanoma|Unresectable Melanoma
Interventions: DRUG: Pazopanib and Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GLP-1 REceptor Agonists and Real World EvIdeNce
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: Long-acting GLP-1RA|DRUG: Short-acting GLP-1RA|DRUG: Human-based GLP-1RA|DRUG: Exendin-based GLP-1RA|DRUG: Fixed ratio BI/GLP-1RA combination|DRUG: Flexible BI/GLP-1RA combination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Bone Marrow and Blood Samples in Patients With Untreated Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia Enrolled on Clinical Trial CALGB-9621 or CALGB-9720
Status: COMPLETED
Conditions: Leukemia
Interventions: OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With CTEPH.
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Riociguat (Adempas, BAY63-2521)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FR901228 in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Mantle Cell Lymphoma
Interventions: DRUG: romidepsin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia
Status: UNKNOWN
Conditions: Fever, Sweats, and Hot Flashes|Infection|Leukemia|Lymphoma|Neutropenia|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: cefepime hydrochloride|DRUG: levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Transiliac Crest Bone Histology and Histomorphometry Study in Postmenopausal Women With Low Bone Mass or Osteoporosis Previously Treated With Denosumab
Status: COMPLETED
Conditions: Low Bone Mass|Low Bone Mineral Density|Osteoporosis|Postmenopausal Osteoporosis
Interventions: DRUG: Previous denosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial to Evaluate Parenteral Treprostinil and Riociguat on Right Ventriculo-vascular Coupling and Morphology in Those With Advanced PAH
Status: UNKNOWN
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Treprostinil Injectable Product|DRUG: Riociguat Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: : Vascular Function in Health and Disease
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|Pulmonary Artery Hypertension|Heart Failure|Hypertension
Interventions: OTHER: Maximum Exercise Tests|DRUG: BH4, L-NMMA, Vitamin C, Vitamin E, α-Lipoic Acid and L-Ascorbate|DRUG: BQ-123|DRUG: Fexofenadine, Ranitidine|OTHER: Angiotensin-II, Valsartan|DRUG: Acetylcholine, Sodium Nitroprusside, Angiotensin-II, Norepinephrine, Phentolamine|DRUG: BQ-123, MitoQ, BH4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy Study of Rezular (Arverapamil) in the Treatment of Irritable Bowel Syndrome With Diarrhea (IBS-D)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Diarrhea
Interventions: DRUG: Rezular 15mg|DRUG: Placebo|DRUG: Rezular|DRUG: Rezular
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Obsessive-compulsive Disorder Treatments: From Lesions to Neuromodulation Targets
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: OTHER: Repetitive Transcranial Magnetic Stimulation|OTHER: Neuronavigation|OTHER: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Profiles Of Amoxicillin 2000 mg And Clavulanate 125 mg In Adolescent Patients
Status: COMPLETED
Conditions: Infections, Respiratory Tract
Interventions: DRUG: amoxicillin/clavulanate potassium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Trial of 48-week Peginterferon Alfa-2a (PEGASYS) to Assess the Sustained Response of Chronic Hepatitis B Patients With HBeAg Seroconversion on Nucleot(s)Ide Analogue Therapy
Status: COMPLETED
Conditions: Chronic Hepaititis B
Interventions: DRUG: Pegyinterferon-alfa-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VNS-induced Corticospinal Plasticity
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Paired-Associative Stimulation (PAS)|OTHER: Vagus Nerve Stimulation (VNS)|OTHER: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Management of Patients With Suspected of Sleep Apnea-hypopnea Syndrome From Primary Care
Status: COMPLETED
Conditions: Sleep Apnea Syndrome
Interventions: OTHER: Primary Care-based management|OTHER: Standard management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combination Therapy of Cord Blood and G-CSF for Patients With Brain Injury or Neurodegenerative Disorders
Status: COMPLETED
Conditions: Brain Injury|Cerebral Palsy|Amyotrophic Lateral Sclerosis|Parkinson's Disease
Interventions: PROCEDURE: Umbilical cord blood therapy|BIOLOGICAL: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Two Formulations of Biphasic Insulin Aspart 70 in Healthy Male Subjects
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: biphasic insulin aspart 70
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Post-marketing Study of Cilostazol (Cilostazol Stroke Prevention Study 2)
Status: COMPLETED
Conditions: Cerebral Infarction
Interventions: DRUG: Cilostazol|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Study to Determine Predictive Markers of Response to BMS-734016 (MDX-010)
Status: COMPLETED
Conditions: Unresectable Stage III or IV Malignant Melanoma
Interventions: DRUG: Ipilimumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Muco-ciliary Cleansing of Lungs in COPD With and Without a Salt Particle Inhaler
Status: SUSPENDED
Conditions: COPD|Copd Bronchitis
Interventions: DEVICE: Inhalation from a salt particle inhaler with or without content
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NOX1416 in Treatment of Chronic Non-Healing Diabetic Foot Ulcers
Status: RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: DRUG: NOX1416 plus SOC|OTHER: Placebo plus SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Plasma Oxalate in Patient With Short Bowel
Status: COMPLETED
Conditions: Short Bowel Syndrome|Hyperoxaluria|Hyperoxalemia
Interventions: BIOLOGICAL: Blood sampling|BIOLOGICAL: Urine sampling|PROCEDURE: Pulse Wave Velocity (PWV) measurement|PROCEDURE: central pressure measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sympathovagal Balance in Smoking Cessation
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Varenicline|DRUG: Placebo|DRUG: Nicorette TX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hypotension Prediction Index-guided Hemodynamic Optimization Trial to Reduce Postoperative Acute Kidney Injury (HYT).
Status: COMPLETED
Conditions: Postoperative Acute Kidney Injury|Postoperative Complications
Interventions: PROCEDURE: Intraoperative hemodynamic management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Andecaliximab in Adults With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Andecaliximab|DRUG: Placebo to match Andecaliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aerogen Nebuliser Versus Standard Nebulised Therapy in Acute Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: COPD
Interventions: DEVICE: The Aerogen Aeroneb Solo©|DEVICE: Phillips Respironic© mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Doxorubicin Hydrochloride in Treating Patients With Sarcoma That is Metastatic or Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Sarcoma
Interventions: DRUG: Doxorubicin Hydrochloride|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multiple Ascending Dose Study of R1511 in Patients With Type 2 Diabetes Mellitus.
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: Placebo|DRUG: RG1511
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-drug-interaction Study of Ramipril, Amlodipine and Atorvastatin
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Ramipril, Amlodipine and Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of PRN1008 in Patients With Pemphigus
Status: TERMINATED
Conditions: Pemphigus
Interventions: DRUG: Rilzabrutinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Focused Ultrasound Surgery in the Treatment of Pain Resulting From Metastatic Bone Tumors With the ExAblate 2100 Conformal Bone System
Status: COMPLETED
Conditions: Bone Cancer|Bone Metastases|Pain
Interventions: DEVICE: ExAblate 2100
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wear and Migration in the Corin Mini-Hip/Metafix and ECIMA Polyethylene
Status: UNKNOWN
Conditions: Hip Osteoarthritis
Interventions: DEVICE: MiniHip (Corin U.K.)|DEVICE: Metafix (Corin, U.K)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Belgian Endothelial Surgical Transplant of the Cornea
Status: RECRUITING
Conditions: Corneal Edema|Corneal Endothelial Disorder|Fuchs' Endothelial Dystrophy|Bullous Keratopathy|Pseudophakic Bullous Keratopathy
Interventions: PROCEDURE: DSAEK|PROCEDURE: DMEK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Training in Children With/At-risk for Attention-Deficit/Hyperactivity Disorder and Executive Function Impairment
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: Brain Training (Active)|BEHAVIORAL: Brain Training (Passive)|BEHAVIORAL: Brain Training (Active or Passive)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect and Safety of Surgical Intervention for Severe Spontaneous Intracerebral Hemorrhage Patients on Long-term Oral Antiplatelet Treatment
Status: COMPLETED
Conditions: Severe Spontaneous Intracranial Hemorrhage|Long-term Antiplatelet Treatment|Emergency Surgery|Complications
Interventions: PROCEDURE: Emergency neurosurgery|PROCEDURE: Conservative treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Personal Cancer Vaccine (NEO-PV-01) w/ Nivolumab for Patients With Melanoma, Lung Cancer or Bladder Cancer
Status: COMPLETED
Conditions: Urinary Bladder Cancer|Bladder Tumors|Transitional Cell Carcinoma of the Bladder|Malignant Melanoma|Melanoma|Skin Cancer|Carcinoma, Non-Small-Cell Lung|Lung Cancer
Interventions: BIOLOGICAL: NEO-PV-01|BIOLOGICAL: Nivolumab|OTHER: Adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dosing of LT4 in Older Individuals
Status: RECRUITING
Conditions: Hypothyroidism
Interventions: DRUG: Levothyroxine Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Promyelocytic Leukemia 2006 (APL)
Status: UNKNOWN
Conditions: Leukemia, Promyelocytic, Acute
Interventions: PROCEDURE: Arsenic trioxide|PROCEDURE: ATRA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D Replacement During Winter Months in Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension|Vitamin D Deficiency
Interventions: DRUG: Cholecalciferol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 6-month Study to Evaluate Sulforaphane Effects in PD Patients
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: Sulforaphane|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest
Status: COMPLETED
Conditions: Cognition Disorders
Interventions: DEVICE: Cardiopulmonary bypass machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Iowa Cochlear Implant Clinical Research Center Hybrid L24 and Standard Cochlear Implants in Profoundly Deaf Infants
Status: COMPLETED
Conditions: Implants, Cochlear|Child|Hearing Loss, Bilateral
Interventions: DEVICE: Hybrid L24
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of ART-123 for the Treatment of Acute Exacerbation of Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: ART-123|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EffectsOfTranscranialPulseStimulationOnDepression-PilotRCT
Status: UNKNOWN
Conditions: Major Depressive Disorder
Interventions: DEVICE: Transcranial Pulse Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Home HIV Testing for Older Adults in South Africa
Status: UNKNOWN
Conditions: HIV Infections|Knowledge, Attitudes, Practice
Interventions: DIAGNOSTIC_TEST: Home HIV self-testing|DIAGNOSTIC_TEST: Home HIV rapid testing|DIAGNOSTIC_TEST: Home HIV self-testing and rapid testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Validation of the Schiller BR-102 Plus PWA Device to Measure Central and Peripheral Hemodynamics
Status: TERMINATED
Conditions: Aortic Stiffness|Hypertension
Interventions: DEVICE: Pulse wave analysis measurement with Schiller BR-102 Plus PWA device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Biology of Resilience
Status: COMPLETED
Conditions: Oxytocin|Placebo
Interventions: DRUG: intranasal oxytocin|DRUG: Placebo|BEHAVIORAL: Social support|BEHAVIORAL: No Social Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: MicroFIBERgut: Effects of Lifestyle Changes and Chitosan on Gut Microbiota and Weight Management
Status: COMPLETED
Conditions: Obesity|Lifestyle
Interventions: BEHAVIORAL: Lifestyle changes|DIETARY_SUPPLEMENT: Chitosan|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylaxis With Ganciclovir Improves Graft Survival in Renal Allograft Recipients
Status: COMPLETED
Conditions: DNA Virus Infection|Herpesviridae Infections|Cytomegalovirus Infection
Interventions: DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Tucidinostat Combined With Tislelizumab as First-line Treatment in Advanced NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Tucidinostat|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Japanese Phase Ib/II Copanlisib in Relapsed, Indolent B-cell NHL
Status: COMPLETED
Conditions: Lymphoma Non-Hodgkin
Interventions: DRUG: Copanlisib (BAY80-6946)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MySlainte: Testing the Effect of Involving Partners in a CVD Prevention Community Lifestyle Program
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Chronic Kidney Diseases|Cardiovascular Risk Factor|Partner, Domestic
Interventions: BEHAVIORAL: 10 week MySlainte Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Target Weaning Oxygen to Determine Cafffeine Duration for AOP
Status: COMPLETED
Conditions: Apnea of Prematurity|Caffeine|Weaning Oxygen|Medicine Regimen
Interventions: DRUG: Caffeine Citrate 20 MG/1 ML Intravenous Solution [CAFCIT]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Citrulline Supplementation in COPD Patients With Malnutrition
Status: NOT_YET_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease Severe|Malnutrition
Interventions: DRUG: L-citrulline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Mirikizumab (LY3074828) in Participants With Moderate to Severe Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Mirikizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Ravulizumab in ALS Participants
Status: TERMINATED
Conditions: Amyotrophic Lateral Sclerosis|ALS
Interventions: DRUG: Placebo|BIOLOGICAL: Ravulizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MEsh FIxation in Laparoendoscopic Repair of Large M3 Inguinal Hernias
Status: RECRUITING
Conditions: Hernia, Inguinal|Hernia, Direct Inguinal
Interventions: PROCEDURE: Non-fixation of the mesh|PROCEDURE: Fixation of the mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Effect of Therapeutic Ultrasound and Trans Cutaneous Electrical Nerve Stimulation on Endometriosis
Status: NOT_YET_RECRUITING
Conditions: Endometriosis
Interventions: DRUG: Medical treatment|DEVICE: Therapeutic ultrasound (US)|DEVICE: Transcutaneous electrical nerve stimulation (TENS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RAD001 Combined With CHOP in Newly Diagnosed Peripheral T-cell Lymphomas
Status: COMPLETED
Conditions: Peripheral T Cell Lymphoma Unspecified|Anaplastic Large Cell Lymphoma, ALK-negative|Angioimmunoblastic T Cell Lymphoma|Cutaneous T Cell Lymphoma
Interventions: DRUG: RAD001 (Everolimus)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions
Status: COMPLETED
Conditions: Marfan Syndrome|Turner Syndrome|Ehlers-Danlos Syndrome|Loeys-Dietz Syndrome|FBN1, TGFBR1, TGFBR2, ACTA2 or MYH11 Genetic Mutation|Bicuspid Aortic Valve Without Known Family History|Bicuspid Aortic Valve With Family History|Bicuspid Aortic Valve With Coarctation|Familial Thoracic Aortic Aneurysm and Dissections|Shprintzen-Goldberg Syndrome|Other Aneur/Diss of Thoracic Aorta Not Due to Trauma, <50yo|Other Congenital Heart Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Novel Edible Gel-based Artificial Saliva in Cancer Patients
Status: COMPLETED
Conditions: Cancer of Head and Neck|Cancer|Radiation-induced Xerostomia|Dry Mouth
Interventions: OTHER: Gel-based artificial saliva
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PRediction Of DIverse Glucocorticoids toxIcity OUtcomeS
Status: UNKNOWN
Conditions: Inflammatory Rheumatism|Polymyalgia Rheumatica|Giant Cell Arteritis|Idiopathic Inflammatory Myopathies|ANCA Associated Vasculitis|Systemic Autoimmune Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Innovative Tool to Limit Spread of COVID 19 in Residential Aged Care Facilities
Status: TERMINATED
Conditions: COVID|Influenza|Gastroenteritis
Interventions: BEHAVIORAL: Gamification|BEHAVIORAL: Newsfeed function
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dose Assessment of Melatonin in Sepsis Trial
Status: WITHDRAWN
Conditions: Sepsis
Interventions: DRUG: Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Frequency Subthalamic Nucleus Deep Brain Stimulation to Improve Verbal Fluency
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DEVICE: STN DBS 10Hz|DEVICE: STN DBS 130Hz|DEVICE: STN DBS off
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Two-part Study in Edoxaban-treated Healthy Subjects to Establish a Punch Biopsy Bleeding Model and to Evaluate the Effect of a 4-factor Prothrombin Complex Concentrate on Anticoagulation
Status: COMPLETED
Conditions: Bleeding
Interventions: DRUG: 60mg edoxaban|DRUG: 180mg edoxaban|DRUG: 50 IU/kg Beriplex P/N|DRUG: 25 IU/kg Beriplex P/N|DRUG: 10 IU/kg Beriplex P/N
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Real Life Study Evaluating the Clinical and Organisational Impact of Moovcare® Lung Connected Medical Device in Lung Cancer Patients : REAL-MOOV-LUNG
Status: RECRUITING
Conditions: Lung Cancer
Interventions: DEVICE: Patients treated for their lung cancer.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pilot Study to Evaluate the Efficacy of Zidovudine in Preventing CD4+ Lymphocyte Decline in Patients With Primary HIV Infection. (One Treatment Arm Receives Placebo)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Perioperative Treatment With Tranexamic Acid in Melanoma
Status: RECRUITING
Conditions: Melanoma
Interventions: DRUG: Tranexamic acid|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Promote Q Cardiac Resynchronization Therapy Defibrillator (CRT-D) and Quartet Left Ventricular Heart Lead Study
Status: COMPLETED
Conditions: Heart Failure
Interventions: DEVICE: CRT-D and LV lead (Quartet™ lead and Promote Q® device system)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Reactogenicity of a Monovalent Conjugated Vaccine Against Haemophilus Influenzae Type b
Status: COMPLETED
Conditions: Haemophilus Influenzae Type b
Interventions: BIOLOGICAL: Haemophilus influenzae type b
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Localized Therapeutics for the Treatment of Gastrointestinal Disorders
Status: COMPLETED
Conditions: Healthy Adults
Interventions: OTHER: Thermosensitive gel rectal formulation|OTHER: Saline enema
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The SAPIEN 3 Ultra System in Intermediate Risk Patients With Symptomatic, Severe Aortic Stenosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: SAPIEN 3 Ultra Delivery System with the SAPIEN 3 Ultra THV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Engineering an Online STI Prevention Program: RCT
Status: COMPLETED
Conditions: Alcohol Consumption|Sexually Transmitted Diseases
Interventions: BEHAVIORAL: itMatters|BEHAVIORAL: itMatters and itMatters Sexual Violence Prevention|BEHAVIORAL: itMatters Well-being and itMatters Sexual Violence Prevention|BEHAVIORAL: itMatters Well-being
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intensity-modulated Radiotherapy With Integrated-boost in Patients With Spinal Bone Metastases
Status: UNKNOWN
Conditions: Vertebral Bony Metastases
Interventions: RADIATION: A|RADIATION: B|RADIATION: C|RADIATION: D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Analgesia Modes in Minimally Invasive Esophagectomy
Status: UNKNOWN
Conditions: Esophageal Cancer|Perioperative Analgesia|NSAIDs|Opioid|Patient-controlled Analgesia
Interventions: DRUG: Preemptive flurbiprofen axetil|DRUG: Postoperative flurbiprofen axetil|DEVICE: Patient-controlled analgesia pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-psychotic Medication (Stable Dose) Weight Loss Study
Status: WITHDRAWN
Conditions: Obesity
Interventions: OTHER: Placebo|DIETARY_SUPPLEMENT: IHBG-10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Central Line Placement-EVALUATION OF LINE DEPTH AS A FACTOR IN NEED FOR LINE REPLACEMENT SECONDARY TO MALPOSITION
Status: WITHDRAWN
Conditions: Vascular Access Complication
Interventions: PROCEDURE: Shallow catheter tip placement|PROCEDURE: Deep catheter tip placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Treatment of Belantamab Mafodotin and Venetoclax in Treatment of Relapsed and Refractory t(11;14) Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma|Multiple Myeloma in Relapse
Interventions: DRUG: Belantamab mafodotin, Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-World Effectiveness of High-Dose Tafamidis on Neurologic Disease Progression in Mixed-Phenotype Transthyretin Amyloid Cardiomyopathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM)
Interventions: DRUG: Tafamidis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Dose Selection Trial of CKD-330 in Patients With Essential Hypertension
Status: UNKNOWN
Conditions: Essential Hypertension
Interventions: DRUG: Candesartan 8mg|DRUG: Candesartan 16mg|DRUG: Amlodipine 5mg|DRUG: Amlodipine 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Buccal Bone Resorption in Immediate Implants in Thin and Thick Buccal Plates of Bone in Esthetic Zone
Status: COMPLETED
Conditions: Buccal Bone Thickness
Interventions: OTHER: immediate implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of ART24 in Subjects Recently Cured of a Clostridioides Difficile Infection (CDI)
Status: COMPLETED
Conditions: Clostridium Difficile Infection Recurrence
Interventions: BIOLOGICAL: ART24|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Scapular Proprioceptive Neuromuscular Facilitation on Pain and Range of Motion in Patients With Adhesive Capsulitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Adhesive Capsulitis
Interventions: PROCEDURE: Conventional Physical Therapy|PROCEDURE: PNF techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Diet-induced Weight Loss in Obese Men
Status: COMPLETED
Conditions: Sexual Dysfunction|Endothelial Dysfunction|Quality of Life|Inflammation
Interventions: DIETARY_SUPPLEMENT: Optifast|BEHAVIORAL: Conventional diet counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Norspan Patch and Oral Tramadol
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Buprenorphine 5mg, 10mg, 20mg vs Tramadol 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Serum Alpha-fetoprotein Levels and Response to Direct Antiviral Therapy in Patients With Chronic Hepatitis C
Status: UNKNOWN
Conditions: Hepatitis C
Interventions: DRUG: Sofosbuvir and Ledipasvir or sofosbuvir and daklatasuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I and Pharmacokinetic Trial of Phenylbutyrate Given as a Continuous Infusion in Pediatric Patients With Refractory Malignancy
Status: COMPLETED
Conditions: Brain Neoplasms|Neuroblastoma
Interventions: DRUG: phenylbutyrate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Secondary Versus Tertiary Wound Closure in High Risk Gynecologic Abdominal Surgical Incisions
Status: TERMINATED
Conditions: Surgical Incision
Interventions: PROCEDURE: Tertiary Wound Closure|PROCEDURE: Historical Wound Closure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treating Patients With Recurrent PCNSL With Carboplatin/BBBD and Adding Rituxan To The Treatment Regimen
Status: TERMINATED
Conditions: Brain and Central Nervous System Tumors|Drug/Agent Toxicity by Tissue/Organ|Lymphoma|Thrombocytopenia
Interventions: DRUG: Rituxan|DRUG: Cyclophosphamide|DRUG: Etoposide|DRUG: Etoposide phosphate|DRUG: Carboplatin|DRUG: Sodium thiosulfate|DRUG: Neupogen|DRUG: Neulasta|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid Versus Vaginal Misoprostol in Abdominal Myomectomy
Status: UNKNOWN
Conditions: Myomectomy
Interventions: DRUG: intravenous tranexamic acid|DRUG: vaginal misoprostol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, and Immunogenicity of V114 in Healthy Japanese Infants (V114-028)
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: V114|BIOLOGICAL: Pneumococcal 13-valent Conjugate Vaccine (PCV13)|BIOLOGICAL: Adsorbed Diphtheria-purified Pertussis-tetanus-inactivated polio (Sabin strain) Combined Vaccine (DTaP-IPV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Safety Evaluation of the GSK-580299 Vaccine in Women From the Control Group in the Primary NCT00294047 Study
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: BIOLOGICAL: GSK580299 (Cervarix)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Role of Anthropometric Measurements and Ultrasonograpic Suprasternal Adipose Tissue Thickness
Status: COMPLETED
Conditions: Intubation; Difficult or Failed|Obesity|Anesthesia
Interventions: DEVICE: Difficult Intubation|DEVICE: Not Difficult Intubation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Testing Implementation Strategies to Support Clinic Fidelity to an Outpatient Hypertension Bundle
Status: ENROLLING_BY_INVITATION
Conditions: Pregnancy Related|Hypertension
Interventions: BEHAVIORAL: Usual Care|BEHAVIORAL: ACHIEVE Multi-component Implementation Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Can You Reduce Diabetes Symptomatology by Becoming Your 'Best Possible Self': The Role of Stress and Resilience
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Best Possible Self
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Safety, Tolerability, Pharmacokinetic Characteristics and Preliminary Efficacy of HLX26 and HLX10 in Patients With Advanced/Metastatic Solid Tumor
Status: COMPLETED
Conditions: Adult Solid Tumor
Interventions: DRUG: HLX26|DRUG: HLX10
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of MSC1936369B in Subjects With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors|Cancer
Interventions: DRUG: MSC1936369B|DRUG: MSC1936369B|DRUG: MSC1936369B|DRUG: MSC1936369B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Animal-Assisted Therapy in the Residential Treatment of Schizophrenia and Addictions
Status: COMPLETED
Conditions: Diagnosis, Dual (Psychiatry)
Interventions: BEHAVIORAL: Animal-assisted therapy (AAT)|OTHER: usual treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT