pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Phase Ib/II Study of Fisogatinib(BLU-554) in Subjects With Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Phase Ib: Fisogatinib (BLU-554) 400mg in combination with Sugemalimab (CS1001) 1200mg|DRUG: Phase Ib: Fisogatinib (BLU-554) 600mg in combination with Sugemalimab (CS1001) 1200mg|DRUG: Phase II: Fisogatinib (BLU-554) 600mg in combination with Sugemalimab (CS1001) 1200mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Building Evidence for Advancing New Treatment for Rifampicin Resistant Tuberculosis (RR-TB) Comparing a Short Course of Treatment (Containing Bedaquiline, Delamanid and Linezolid) With the Current South African Standard of Care
Status: COMPLETED
Conditions: Tuberculosis|Pre-XDR-TB|Extensively Drug-Resistant Tuberculosis|Multi Drug Resistant Tuberculosis|Rifampicin Resistant Tuberculosis
Interventions: DRUG: Bedaquiline Oral Tablet|DRUG: Linezolid Oral Tablet|DRUG: Delamanid in Oral Dosage Form|DRUG: Clofazimine Oral Product|DRUG: Levofloxacin Oral Tablet|DRUG: Isoniazid Oral Product|DRUG: Ethambutol Oral Product|DRUG: Pyrazinamide Oral Product|DRUG: Linezolid Oral Tablet|DRUG: Clofazimine Oral Product|DRUG: Levofloxacin Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Iron Chelation as TReatment of Oxidative Damage in Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: Deferasirox 360 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of Cryotherapy on the Fatigue of Patients With Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DEVICE: partial-body cryotherapy chamber session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pegylated Liposomal Doxorubicine and Prolonged Temozolomide in Addition to Radiotherapy in Newly Diagnosed Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: Pegylated Liposomal Doxorubicine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mallampati Score for Prediction and Prognosis of Postoperative Mortality and Morbidity and Safety Profiles of Patients Undergoing Laparoscopic Cholecystectomy in Qassim Region
Status: ACTIVE_NOT_RECRUITING
Conditions: Mallampati Score|Difficult Intubation|Patient Satisfaction|Cholestasis|Cholecystitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Hormonal Therapy: Mediating Hot Flashes Tapering Regimens for Mediating Hot Flashes
Status: UNKNOWN
Conditions: Hot Flashes|Night Sweats
Interventions: DRUG: Estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of an AI-based Biliopancreatic EUS Navigation System for Real-time Quality Improvement: A Prospective, Single-center, Randomized Controlled Trial
Status: UNKNOWN
Conditions: Endoscopic Ultrasonography|Pancreatic Disease|Bile Duct Diseases|Artificial Intelligence
Interventions: OTHER: AI-based biliopancreatic EUS navigation system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral Insulin (IN-105) in Type 1 Diabetes Patients
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: IN-105|DRUG: Insulin Lispro Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Memory and Attention Adaptation Training-Geriatrics (MAAT-G) Phase II
Status: COMPLETED
Conditions: Cancer-related Problem/Condition|Cognitive Impairment
Interventions: BEHAVIORAL: MAAT-G|BEHAVIORAL: Supportive therapy (time and attention control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Technical Innovation of Prismatic Adaptation Test in Healthy Subject, in Favour of Autonomy and Independence in Daily Life Following a Brain Injury
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: BEHAVIORAL: Prismatic goggles|BEHAVIORAL: Virtual reality device|BEHAVIORAL: Prismatic goggles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Distal Transradial Access for Percutaneous Coronary Intervention
Status: COMPLETED
Conditions: Transradial Access|Coronary Angiography|Radial Artery Intimal Medial Thickness|Distal Radial Artery Access (dTRA)
Interventions: PROCEDURE: dTRA|PROCEDURE: fTRA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electroconvulsive Therapy in Clozapine-resistant Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DEVICE: electroconvulsive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Xenogeneic Collagen Matrix as an Alternative to Free Gingival Grafting for Oral Soft Tissue Augmentation
Status: COMPLETED
Conditions: Gingival Diseases
Interventions: DEVICE: Xenogeneic Collagen Matrix|DEVICE: Free Gingival Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Participatory Evaluation (of) Aging (With) Rapamycin (for) Longevity Study
Status: COMPLETED
Conditions: Aging
Interventions: DRUG: Rapamycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intercostal Nerves Block in the Midaxillary Line Versus Paravertebral Block for no Reconstructive Breast Surgery
Status: UNKNOWN
Conditions: no Reconstructive Breast Surgery
Interventions: PROCEDURE: BRILMA|PROCEDURE: paravertebral block|DRUG: dexketoprofen|DRUG: paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exploratory Positron Emission Tomography (PET) Study to Evaluate the Effects of ABT-614 on [11C]-(+)-PHNO Binding Potential to D3 Receptors in the Brain
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: ABT-614
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Safety of HIN1 Monovalent Vaccine (MEDI3414) in Children 2 to 17 Years of Age
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: MEDI3414 [Influenza A(H1N1) live attenuated, intranasal]|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Study of Rindopepimut (CDX-110) in Patients With Glioblastoma Multiforme
Status: COMPLETED
Conditions: Malignant Glioma
Interventions: DRUG: CDX-110 with GM-CSF|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seropositive Chronic Lyme Disease
Status: COMPLETED
Conditions: Lyme Disease
Interventions: DRUG: ceftriaxone|DRUG: doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Ceritinib and Everolimus in Treating Patients With Locally Advanced or Metastatic Solid Tumors or Stage IIIB-IV Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: ALK Positive|Locally Advanced Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm|ROS1 Gene Rearrangement|Stage IIIB Lung Non-Small Cell Cancer AJCC v7|Stage IV Lung Non-Small Cell Cancer AJCC v7
Interventions: DRUG: Ceritinib|DRUG: Everolimus|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caring for Caregivers With Mind-body Exercise
Status: UNKNOWN
Conditions: Caregiver Distress|Physical Function|Quality of Life
Interventions: OTHER: Baduanjin Qigong, Community-based|OTHER: Baduanjin Qigong, Internet-based
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Ureteroscopic Lithotripsy (Including Flexible Ureteroscopy) Without Indwelling Urinary Catheter
Status: NOT_YET_RECRUITING
Conditions: Urolithiasis|Catheter-related Bladder Discomfort
Interventions: PROCEDURE: Ureteroscopy (including flexible endoscope) lithotripsy without indwelling urinary catheter|PROCEDURE: Ureteroscopy (including flexible endoscope) lithotripsy with indwelling urinary catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metformin and Esomeprazole in Treatment of Early Onset Preeclampsia
Status: UNKNOWN
Conditions: Pre-Eclampsia
Interventions: DRUG: metformin|DRUG: esomeprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trigen InterTAN vs Sliding Hip Screw RCT
Status: TERMINATED
Conditions: Hip Fractures
Interventions: DEVICE: Trigen Intertan|OTHER: Post-Surgery Follow Up|DEVICE: Sliding Hip Screw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Dose Escalation Study of BKM120 With Radiation Therapy and Temozolomide in Patients With Newly Diagnosed Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: BKM120 + temozolomide|DRUG: BKM120 +temozolomide with/without radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Tecadenoson to Treat Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Tecadenoson|DRUG: Esmolol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Recovery Supplement on Body Composition, Performance, Muscular Properties, and Wellbeing
Status: COMPLETED
Conditions: Protein Deficiency|Training Group, Sensitivity|Fatigue|Muscular Atrophy|Psychological
Interventions: DIETARY_SUPPLEMENT: Ingestion of a Post-Workout Supplement|DIETARY_SUPPLEMENT: Ingestion of a Maltodextrin Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Rituximab in Treating Patients With Relapsed Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: cisplatin|DRUG: cytarabine|DRUG: dexamethasone|DRUG: sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of Nicotine Patches in SARS-CoV2 (COVID-19) Infection in Hospitalized Patients
Status: COMPLETED
Conditions: SARS-COV2
Interventions: DRUG: Nicotine 7 mg/ 24h Transdermal Patch - 24 Hour|DRUG: Placebo of NICOTINE Transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Telerehabilitation Based Motor Imagery and Action Observation Training in Multiple Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis
Interventions: OTHER: Traditional rehabilitation|OTHER: Action observation therapy and motor imagery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Relationship Between Scapular Endurance, Core Endurance, and Functional Performance in Adolescent Tennis Players
Status: ACTIVE_NOT_RECRUITING
Conditions: Athletic Injuries|Sports Physical Therapy
Interventions: DIAGNOSTIC_TEST: Assessment of scapular endurance|DIAGNOSTIC_TEST: Prone Bridge Test|DIAGNOSTIC_TEST: Side Bridge Test|DIAGNOSTIC_TEST: Closed Kinetic Chain Upper Extremity Stability Test|DIAGNOSTIC_TEST: Seated Medicine Ball Throw Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability and Pharmacokinetics of BIBW 2948 BS in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIBW 2948 BS for oral inhalation|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - Nested Registry 3/Valve-in-Valve
Status: COMPLETED
Conditions: Aortic Stenosis|Cardiomyopathy, Hypertrophic
Interventions: DEVICE: Edwards SAPIEN XT transcatheter valve, Model 9300TFX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy of Intralesional Corticosteroid on the Treatment of Frontal Fibrosing Alopecia
Status: UNKNOWN
Conditions: Frontal Fibrosing Alopecia
Interventions: OTHER: Corticosteroid/Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protect and Improve Cluster of Differentiation 4 (CD4) Cells and B Cells Lymphocytes
Status: COMPLETED
Conditions: HIV-1-infection|AIDS
Interventions: DRUG: Ahah Drug|DEVICE: Ahah Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of Novavax Vaccine(s) as Booster Dose After mRNA Vaccines
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: NVX-CoV2373|BIOLOGICAL: SARS-CoV-2 rS antigen/Matrix-M Adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Minimal Occlusive Pressure With Cuffed ETT: the Effect of Size on Intracuff Pressure
Status: COMPLETED
Conditions: Intracuff Pressure|ETT Size
Interventions: PROCEDURE: Surgery less than 60 minutes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of a Plant Sterols-Enriched Low-Fat Milk on Lipid Profile in Healthy Southern Chinese (COME-PASS)
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DIETARY_SUPPLEMENT: Plant sterols-enriched low-fat milk|DIETARY_SUPPLEMENT: Low-fat milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Efficacy, and Pharmacokinetic Profile of DNB-001 in Subjects With Elevated Intraocular Pressure
Status: COMPLETED
Conditions: Ocular Hypertension|Elevated IOP|Glaucoma
Interventions: DRUG: DNB-001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Faecal Incontinence With Sacral Nerve Stimulation - Improved Function With Stimulation Bilaterally?
Status: TERMINATED
Conditions: Fecal Incontinence
Interventions: DEVICE: Medtronic INTERSIM II - 3058
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerance Induction in Living Donor Kidney Transplantation With Hematopoietic Stem Cell Transplantation
Status: UNKNOWN
Conditions: End Stage Renal Disease
Interventions: PROCEDURE: Transplantation Conditioning for BMT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel Combined With Carboplatin Plus Anlotinib as First Line Treatment in NSCLC
Status: UNKNOWN
Conditions: NSCLC
Interventions: DRUG: Anlotinib|DRUG: Docetaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxepa in Multiple Trauma
Status: UNKNOWN
Conditions: Multiple Trauma|Head Trauma
Interventions: DIETARY_SUPPLEMENT: Oxepa (enteral nutrition formula, ABBOTT), at a dose determined by a patient's energy expenditure and tolerance of enteral feeding.|DIETARY_SUPPLEMENT: oxepa|DIETARY_SUPPLEMENT: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Randomized Trial of Immunotherapy Plus Radiotherapy in Metastatic Genitourinary Cancers
Status: TERMINATED
Conditions: Metastatic Renal Cell Carcinoma|Metastatic Urothelial Carcinoma
Interventions: DRUG: Nivolumab|DRUG: Atezolizumab|RADIATION: Radiation & immunotherapy|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Topical Analgesia for Laceration Repair in the Emergency Department
Status: COMPLETED
Conditions: Pain, Acute|Laceration
Interventions: DRUG: Lidocaine-Prilocaine Cream 2.5-2.5%|DRUG: Lidocaine 1% Epinephrine 0.005mg/mL solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photoirritation and Photoallergic Potential of a New Nicotine Patch
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Nicotine Patch|DRUG: Placebo Patch|DRUG: No Patch Control|RADIATION: UVA and UVB irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Single Arm, Open Label Trial With Iptacopan Treatment for 24 Weeks, in Patients on Stable Regimen of Anti-C5 Who Switch to Iptacopan.
Status: ACTIVE_NOT_RECRUITING
Conditions: Paroxysmal Nocturnal Hemoglobinuria
Interventions: DRUG: Iptacopan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alterations in Intestinal Microbiota, Metabolites, and Immune Cells in Allo-HSCT
Status: RECRUITING
Conditions: Graft Vs Host Disease
Interventions: DIAGNOSTIC_TEST: Blood Sample|DIAGNOSTIC_TEST: Stool Sample|DIAGNOSTIC_TEST: Urine Sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intraperitoneal Paclitaxel and Carboplatin in the Treatment of Women With Carcinoma of Mullerian Origin
Status: COMPLETED
Conditions: Ovarian Carcinoma
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study Evaluating Vildagliptin Versus Vildagliptin/Metformin on NAFLD With DM
Status: RECRUITING
Conditions: dm
Interventions: DRUG: Vildagliptin|DRUG: vildagliptin\metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zoledronate in Preventing Skeletal (Bone)-Related Events in Men Who Are Receiving Androgen Deprivation Therapy For Prostate Cancer and Bone Metastases
Status: COMPLETED
Conditions: Metastatic Cancer|Prostate Cancer
Interventions: DRUG: zoledronic acid|OTHER: placebo|DRUG: androgen deprivation therapy|DRUG: GnRH agonist|DIETARY_SUPPLEMENT: Calcium supplement|DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Validation of Polydeep: an Artificial Intelligence-based Computer-aided Polyp Detection (CADe) and Characterization (CADx) System
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: Sensitivity of Polydeep vs high experienced endoscopists for colorectal polyp detection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Anterior Chest Compression Assist and Abdominal Thrust Assist Technique COPD
Status: COMPLETED
Conditions: COPD
Interventions: OTHER: Anterior Chest Compression technique|OTHER: Abdominal Thrust Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Walking Meditation Training on Glycemic Control and Vascular Function in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: OTHER: Walking Meditation|OTHER: Walking|OTHER: No exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SEPSIS: L. Plantarum Trial
Status: COMPLETED
Conditions: Microbial Colonization|Tolerance|Safety Issues|Infant ALL
Interventions: DIETARY_SUPPLEMENT: Synbiotic|DIETARY_SUPPLEMENT: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Gemcitabine and Docetaxel in Combination With Pazopanib (Gem/Doce/Pzb) for the Neoadjuvant Treatment of Soft Tissue Sarcoma (STS)
Status: TERMINATED
Conditions: Sarcoma|Leiomyosarcoma|Malignant Peripheral Nerve Sheath Tumor|Malignant Fibrous|Histiocytoma/Undifferentiated Pleomorphic Sarcoma
Interventions: DRUG: Pazopanib 400 mg QD - Gemcitabine and Docetaxel in Combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GLP-1 Therapy: The Role of IL-6 Signaling and Adipose Tissue Remodeling in Metabolic Response
Status: ACTIVE_NOT_RECRUITING
Conditions: Glucose Intolerance|Overweight and Obesity|Drug Effect|Adiposity
Interventions: DRUG: Cyanocobalamin|DRUG: Dulaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Endoloop Mediated Cardioplication to Treat Gastroesophageal Reflux Disease
Status: NOT_YET_RECRUITING
Conditions: Gastroesophageal Reflux Disease
Interventions: PROCEDURE: endoloop mediated cardioplication (ECLC) procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between IT Fentanyl and IV Granisetron in Prevention of Vomiting in CS Under Spinal Anesthesia
Status: RECRUITING
Conditions: Nausea and Vomiting, Postoperative
Interventions: DRUG: Fentanyl|DRUG: Bupivacain|DRUG: intravenous graniseton
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Proton Therapy to Reduce Acute Normal Tissue Toxicity in Locally Advanced Non-small-cell Lung Cancer
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: RADIATION: Proton therapy|RADIATION: Photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of IDA for Onchocerciasis
Status: COMPLETED
Conditions: Onchocerciasis
Interventions: DRUG: IVM w/ ALB|DRUG: Single dose of IDA|DRUG: Three daily doses of IDA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dendritic Cell Immunotherapy Plus Standard Treatment of Advanced Renal Cell Carcinoma
Status: TERMINATED
Conditions: Advanced Renal Cell Carcinoma
Interventions: BIOLOGICAL: CMN-001|BIOLOGICAL: Nivolumab+Ipilimumab|DRUG: Lenvatinib+Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of PCSK9-Antibody (Alirocumab) on Dyslipidemia Secondary to Nephrotic Syndrome
Status: TERMINATED
Conditions: Nephrotic Syndrome
Interventions: DRUG: Alirocumab|DRUG: Alirocumab placebo|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DDI Between BI Empagliflozin (10773) and Verapamil
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Verapamil|DRUG: BI 10773|DRUG: BI 10773
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclosporine 0.05% Eye Drops for Vernal Keratoconjunctivitis Trial
Status: COMPLETED
Conditions: Vernal Keratoconjunctivitis|Cyclosporine 0.05% Eye Drops
Interventions: DRUG: Cyclosporine 0.05% eye drops|DRUG: Loteprednol Etabonate 0.5% and Tobramycin Eye Drops 0.3%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SPAGO: Sirolimus Paclitaxel Angiographic Gain Objective
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease|Stenosis Coronary|Coronary Artery Lesion|Percutaneous Coronary Intervention
Interventions: DEVICE: sirolimus-eluting balloon (Selution)|DEVICE: paclitaxel-eluting balloon (SeQuent Please Neo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy and Tolerability of Vilazodone in Patients With Generalized Anxiety Disorder
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: DRUG: Placebo|DRUG: Vilazadone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Usefullness of the Cuffless SOMNOtouch NIBP Device for 24-hour Ambulatory Blood Pressure Measurement
Status: COMPLETED
Conditions: Arterial Hypertension
Interventions: DEVICE: Dual 24-hour ABPM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Critical Illness Myopathy as a Cause of Debilitating ICU-Acquired Weakness
Status: ACTIVE_NOT_RECRUITING
Conditions: Myopathy|Cognitive Impairment
Interventions: PROCEDURE: Biopsy/Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Sunlight Exposure and Outdoor Activities on Depression, Cognition and Quality of Life in the Elderly
Status: UNKNOWN
Conditions: Aging|Nursing Homes|Depression in Old Age|Cognitive Impairment|Quality of Life
Interventions: BEHAVIORAL: sunlight exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of ONO-8539 on Oesophageal Pain Hypersensitivity in Patients With Non-erosive Reflux Disease
Status: COMPLETED
Conditions: GERD
Interventions: DRUG: ONO-8539|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Theophylline Prophylaxis During Hypothermia to Limit Neonatal Nephron Damage
Status: RECRUITING
Conditions: Acute Kidney Injury|HIE
Interventions: DRUG: Single Dose Theophylline|DRUG: Repeat Dose Theophylline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Chemotherapy After Prostatectomy (CAP) For High Risk Prostate Carcinoma
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Docetaxel|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tadalafil in Chronic Obstructive Lung Disease Patients Suffering From Secondary Pulmonary Hypertension
Status: WITHDRAWN
Conditions: Chronic Obstructive Lung Disease
Interventions: DRUG: Tadalafil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Hydration With Sodium Bicarbonate for Long-Term Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing an Emergent Coronary Procedure
Status: UNKNOWN
Conditions: Chronic Renal Failure
Interventions: DRUG: N-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A Clinical Study on the Efficacy and Safety of ABCD in the Treatment of Patients With Invasive Fungal Disease
Status: NOT_YET_RECRUITING
Conditions: Invasive Fungal Disease
Interventions: DRUG: Amphotericin B cholesterol-sulfate complex for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of the Prophylactic Use of PEG-rhG-CSF in Children With Hematological Malignancies
Status: UNKNOWN
Conditions: Lymphoma|Leukemia
Interventions: DRUG: PEG-rhG-CSF group|DRUG: rhG-CSF group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Testing the Addition of Duvelisib or CC-486 to the Usual Treatment for Peripheral T-Cell Lymphoma
Status: RECRUITING
Conditions: Angioimmunoblastic T-cell Lymphoma|Enteropathy-Associated T-Cell Lymphoma|Follicular T-Cell Lymphoma|Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma|Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma|Nodal Peripheral T-Cell Lymphoma With TFH Phenotype|Peripheral T-Cell Lymphoma, Not Otherwise Specified
Interventions: DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone|DRUG: Etoposide|DRUG: Duvelisib|DRUG: Oral azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Mediators and Metabolites to Stratify Systemic Lupus Erythematosus Patients at High Risk of Cardio Vascular Diseases
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: blood sample|OTHER: Ultrasonography assessment|BEHAVIORAL: questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Three-Arm Comparative Trial for the Treatment of MAC Bacteremia in AIDS: A Clarithromycin/Ethambutol Regimen Containing Rifabutin (450 Mg) or Rifabutin (300 Mg) or Placebo
Status: COMPLETED
Conditions: Mycobacterium Avium-Intracellulare Infection|HIV Infections
Interventions: DRUG: Ethambutol hydrochloride|DRUG: Clarithromycin|DRUG: Rifabutin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Single and Multiple Doses of LP-005 in Healthy Adult Participants
Status: RECRUITING
Conditions: Paroxysmal Nocturnal Hemoglobinuria (PNH)
Interventions: BIOLOGICAL: LP-005 Dose 1 (Single)|BIOLOGICAL: LP-005 Dose 2 (Single)|BIOLOGICAL: LP-005 Dose 3 (Single)|BIOLOGICAL: LP-005 Dose 4 (Single)|BIOLOGICAL: LP-005 Dose 5 (Single)|BIOLOGICAL: LP-005 Dose 6 (Single)|BIOLOGICAL: Placebo (Single)|BIOLOGICAL: LP-005 Dose 7 (Multiple)|BIOLOGICAL: LP-005 Dose 8 (Multiple)|BIOLOGICAL: LP-005 Dose 9 (Multiple)|BIOLOGICAL: Placebo (Multiple)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FRAGINOC Study: Screening and Geriatric Assessment and Intervention in Older Patients With Epithelial Ovarian Cancer
Status: RECRUITING
Conditions: Ovarian Cancer|Frailty
Interventions: OTHER: Comprehensive geriatric assessment and individualised physical training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of TRIA-662 500 mg and Niaspan 1000 mg in Healthy Male and Female Volunteers Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Niaspan|DRUG: TRIA-662
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Safety, Tolerability, Efficacy and Pharmacokinetics of Imipenem/Cilastatin/Relebactam (MK-7655A) in Pediatric Participants With Gram-negative Bacterial Infection (MK-7655A-021)
Status: COMPLETED
Conditions: Suspected or Documented Gram-negative Bacterial Infection
Interventions: DRUG: IMI/REL|DRUG: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of mMASI Before and After Hyperthyroid Therapy in Hyperthyroid Subjects With Melasma
Status: COMPLETED
Conditions: Melasma|Hyperthyroidism
Interventions: DRUG: Thiamazol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Promotora Navigator - Culturally Appropriate Patient Navigator
Status: COMPLETED
Conditions: Breast Cancer|Screening Mammography|Community Health Worker
Interventions: BEHAVIORAL: Mammography with Community Health Worker (individual)|BEHAVIORAL: Mammography with Community Health Worker (group)|OTHER: Standard of Care Mammography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Efficacy and Safety of ELIXCYTE Intra-articular Injection in Subject With Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: ELIXCYTE|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-blind, Comparative Study of Intravenous Iron Isomaltoside 1000 (Monofer®) Against Placebo
Status: WITHDRAWN
Conditions: Iron Deficiency Anemia
Interventions: DRUG: Iron isomaltoside 1000|DRUG: Natrium Chloride 0,9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Edwards EVOQUE Eos MISCEND Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Mitral Valve Regurgitation (Degenerative or Functional)
Interventions: DEVICE: Edwards EVOQUE Eos Mitral Valve Replacement System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aspirin and Statins for Prevention of Atherosclerosis and Arterial Thromboembolism in Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Atherosclerosis|Thromboembolism|Systemic Lupus Erythematosus
Interventions: DRUG: Rosuvastatin|DRUG: placebo|DRUG: aspirin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Total Body Irradiation +/- Total Lymphoid Irradiation & Anti-Thymocyte Globulin in Non-myeloablative Hematopoietic Cell Transplantation
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes|Myeloproliferative Disorder|Chronic Lymphocytic Leukemia|B-cell Lymphoma|T-cell Lymphoma|Non Hodgkin Lymphoma|Hodgkin Lymphoma|Chronic Myelomonocytic Leukemia
Interventions: RADIATION: Total body irradiation (TBI)|DRUG: Anti-thymocyte globulin (ATG)|DRUG: Tacrolimus|DRUG: Mycophenolate mofetil (MMF)|RADIATION: Total lymphoid irradiation (TLI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prosthetic Component Relationship of the Reversed Delta III Total Shoulder Prosthesis in the Transverse Plane of the Body
Status: COMPLETED
Conditions: Shoulder Prosthesis
Interventions: PROCEDURE: Evaluation of the placement of the Delta prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperinflation Assessment After Treatment by Lung Volume Reduction Coil
Status: TERMINATED
Conditions: Emphysema
Interventions: PROCEDURE: Bronchoscopy|DEVICE: Lung Volume Reduction Coil (HEAT-LVRC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapip Study: Clinical Trial on Remifentanyl for Analgesia and Sedation of Ventilated Neonates and Infants
Status: COMPLETED
Conditions: Mechanical Ventilation
Interventions: DRUG: Remifentanyl|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Remifentanil for Rapid Sequence Induction and Intubation in Full Stomach Patient Compared to Muscle Relaxant
Status: COMPLETED
Conditions: Intra-tracheal Intubation
Interventions: DRUG: Remifentanil group|DRUG: neuromuscular blockade group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Cholecalciferol Supplementation in Patients With Chronic Heart Failure and LOw vITamind D Levels
Status: UNKNOWN
Conditions: Heart Failure|Vitamin D Deficiency
Interventions: DRUG: CHOLECALCIFEROL|DRUG: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NKG2D/CLDN18.2 CAR-T(KD-496) in the Treatment of Advanced NKG2DL+/CLDN18.2+ Solid Tumors
Status: RECRUITING
Conditions: Gastric Cancer|Pancreatic Cancer|Solid Tumor
Interventions: BIOLOGICAL: KD-496
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Tranexamic Acid During Vaginal Hysteractomy to Reduce Blood Loss
Status: UNKNOWN
Conditions: Blood Loss
Interventions: DRUG: local tranexamic acid injection|OTHER: local normal saline injection to cervix|DRUG: IV 1 g tranexamic acid|OTHER: IV 1 g normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Air-polishing on Pain Perception and Compliance Rate
Status: RECRUITING
Conditions: Peri-Implantitis|Peri-implant Mucositis
Interventions: PROCEDURE: Debridement with ultrasonic device and scaling with plastic curettes|PROCEDURE: Debridement with erythritol based air-polishing powde
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of N-Acetyl-L-Cysteine, on Inflammatory and Oxidative Stress Markers in Pulmonary Sarcoidosis
Status: COMPLETED
Conditions: Pulmonary Sarcoidosis
Interventions: DIETARY_SUPPLEMENT: N-acetyl-cysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Unilateral Epidural Block Versus Ultrasound Guided Combined Femoro-sciatic Nerves Block for Patients With Low Ejection Fraction
Status: UNKNOWN
Conditions: Low Ejection Fraction Patients|Fracture Tibia
Interventions: PROCEDURE: unilateral epidural anesthesia|PROCEDURE: Ultrasound guided femoro/ sciatic nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Ibuprofen and Laser on Orthodontic Pain
Status: COMPLETED
Conditions: Crowding, Tooth
Interventions: DRUG: 400 Mg Ibuprofen|DEVICE: laser application|OTHER: placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Reducing Breathlessness With Dronabinol in COPD Patients
Status: NOT_YET_RECRUITING
Conditions: COPD|Breathlessness|Cannabis
Interventions: DRUG: Dronabinol 2.5mg Capsule|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies
Status: COMPLETED
Conditions: Hematologic Malignancy
Interventions: RADIATION: Total Body Irradiation|BIOLOGICAL: Donor Lymphocyte Infusion (DLI)|DRUG: Cyclophosphamide|DRUG: Tacrolimus|DRUG: Mycophenolate mofetil|PROCEDURE: Allogeneic hematopoietic stem cell transplantation|OTHER: Laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extubation in Pediatric Patients: Proactive or Passive?
Status: ENROLLING_BY_INVITATION
Conditions: Cough|Tracheal Extubation
Interventions: BEHAVIORAL: proactive extubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Attention Training for Learning Enhancement and Resilience Trial
Status: COMPLETED
Conditions: Age-related Cognitive Decline
Interventions: OTHER: Computerized Plasticity-Based Adaptive Cognitive Training|OTHER: Commercially available computerized training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maladaptive Psychosocial Beliefs and Adolescents With Patellofemoral Pain
Status: COMPLETED
Conditions: Patellofemoral Pain Syndrome|Knee Pain Chronic|Patellofemoral Syndrome|Anterior Knee Pain Syndrome
Interventions: OTHER: Psychologically Informed Education|OTHER: Biomedical Education (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TLC399 (ProDex) in Subjects With Macular Edema Due to Retinal Vein Occlusion (RVO)
Status: COMPLETED
Conditions: Retinal Vein Occlusion|Macula Edema
Interventions: DRUG: TLC399 (ProDex)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment Optimisation for Blood Pressure With Single-Pill Combinations in India
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Hypertension
Interventions: DRUG: Amlodipine + Perindopril|DRUG: Perindopril + Indapamide|DRUG: Amlodipine + Indapamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect on EPCs by Successful Cardiac Occlusion Device Implantation
Status: COMPLETED
Conditions: Foramen Ovale, Patent|Heart Septal Defects, Atrial|Atrial Septal Defect
Interventions: OTHER: Blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Randomized Study of Combination Chemotherapy With or Without Focused Microwave Thermotherapy Before Surgery in Treating Women With Large Breast Cancer Tumors
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DEVICE: Focused Microwave Thermotherapy|DRUG: Chemotherapy (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Pregabalin in Patients With Diabetic Peripheral Neuropathy.
Status: COMPLETED
Conditions: Diabetic Neuropathy, Painful
Interventions: DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dendritic Cell Therapy After Cryosurgery in Combination With Pembrolizumab in Treating Patients With Stage III-IV Melanoma That Cannot Be Remove by Surgery
Status: COMPLETED
Conditions: Stage III Cutaneous Melanoma AJCC v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7
Interventions: PROCEDURE: Cryosurgery|BIOLOGICAL: Pembrolizumab|PROCEDURE: Pheresis|BIOLOGICAL: Therapeutic Autologous Dendritic Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT