pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: RAM Cannula Versus Short Bi-nasal Cannula in Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Newborn
Interventions: DEVICE: nasal CPAP support with RAM cannula|DEVICE: nasal CPAP support with Hudson cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of a Single-pill Fixed Combination of Sufficient Losartan/Hydrochlorothiazide in Chinese Hypertensive Patients
Status: RECRUITING
Conditions: Hypertension
Interventions: DRUG: losartan/hydrochlorothiazide|DRUG: amlodipine/hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effectiveness of Concurrent Peer Review for Patients With Cardiovascular Disease and Diabetes
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: OTHER: Usual Care|BEHAVIORAL: Concurrent Peer Review visit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Work Interventions to Improve Employment Outcomes for Persons With Rheumatoid Arthritis and Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis|Rheumatoid Arthritis
Interventions: BEHAVIORAL: On-site work evaluation|BEHAVIORAL: Educational material
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Transcutaneous Tibial Nerve Stimulation as Treatment for Women With Primary Dysmenorrhea
Status: COMPLETED
Conditions: Dysmenorrhea Primary
Interventions: PROCEDURE: Transcutaneous tibial nerve stimulation|PROCEDURE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Anticoagulant Preventive Injection in Patients With Blood Cancer
Status: COMPLETED
Conditions: Lymphoma|Multiple Myeloma
Interventions: DRUG: Tinzaparin|OTHER: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: This is a Dose-finding Study Followed by 2-year Extension Study to Evaluate Safety and Tolerability of Tinlarebant in Adolescent Subjects With Stargardt Disease
Status: COMPLETED
Conditions: Stargardt Disease
Interventions: DRUG: tinlarebant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Long-Acting Acetaminophen in Postoperative Dental Pain
Status: COMPLETED
Conditions: Dental Pain
Interventions: DRUG: Acetaminophen ER|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analyze Changes in Respiratory Rate When Using the Scare Respirator
Status: COMPLETED
Conditions: Apnea of Newborn|Preterm Labor
Interventions: DEVICE: No intervention|DEVICE: scare ventilator at 20|DEVICE: scare ventilator at 40
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.
Status: RECRUITING
Conditions: Oligometastatic Prostate Cancer (OMPC)
Interventions: DRUG: AAA617
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FLOX in Combination With Cetuximab in First-line Treatment of Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: FLOX (5-fluorouracil/folinic acid/oxaliplatin)|DRUG: FLOX (5-fluorouracil/folinic acid/oxaliplatin) and Cetuximab|DRUG: FLOX (5-fluorouracil and folinic acid and oxaliplatin) intermittently and maintenance cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Video Double-Lumen Tube Prospective Randomized Study
Status: COMPLETED
Conditions: Other Surgical Procedures
Interventions: DEVICE: Non-Video Double Lumen Tube (DLT)|PROCEDURE: Fiberoptic Bronchoscopy (FOB)|DEVICE: Video Double Lumen Tube (VDLT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Low FODMAP Plus PEG 3350 for the Treatment of Patients With Irritable Bowel Syndrome-Constipation
Status: RECRUITING
Conditions: Irritable Bowel Syndrome Characterized by Constipation
Interventions: OTHER: Low FODMAP diet/PEG 3350|OTHER: sham diet/PEG 3350
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Endoscopic Surgery Followed by Chemotherapy and Proton Radiation for the Treatment of Tumors in the Sinus and Nasal Passages
Status: COMPLETED
Conditions: Paranasal Sinus Cancer|Nasal Cavity Tumor|Nasal Cavity Adenocarcinoma
Interventions: DRUG: Cisplatin|RADIATION: Adjuvant Proton Radiotherapy|PROCEDURE: Endoscopic Resection|DRUG: cisplatin and etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Observational Study of Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT) Who Switched IOP-lowering Treatments
Status: COMPLETED
Conditions: Glaucoma, Open-Angle|Ocular Hypertension
Interventions: DRUG: Prostaglandin Analogue -Containing IOP-Lowering Therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Different Amoxicillin Treatment Regimens in Erythema Migrans Patients
Status: RECRUITING
Conditions: Erythema Migrans
Interventions: DRUG: EM-amoxicillin 3 x 10 days|DRUG: EM-amoxicillin 3 x 14 days|DRUG: EM-amoxicillin 2 x 14 days|OTHER: Controls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Choose to Move - Next Steps: Can 'Booster Sessions' Sustain Health Benefits of an Effective, Scaled-up, Health Promotion Program?
Status: ACTIVE_NOT_RECRUITING
Conditions: Aging|Mobility Limitation|Sedentary Behavior|Loneliness|Social Isolation
Interventions: BEHAVIORAL: Choose to Move - Next Steps
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vagus Nerve Stimulation in Treatment of Postural Orthostatic Tachycardia Syndrome
Status: COMPLETED
Conditions: Postural Orthostatic Tachycardia Syndrome
Interventions: DEVICE: Parasym (TM) Transcutaneous Electrical Nerve Stimulation (TENS) Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cranial Electrotherapy for Military Beneficiaries With Restless Legs Syndrome
Status: UNKNOWN
Conditions: Restless Legs Syndrome
Interventions: DEVICE: Active CES Device Alpha-Stim®|DEVICE: Sham Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Aripiprazole in Patients With Bipolar I Disorder With a Major Depression Episode
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Aripiprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Economic Empowerment Program Suubi-Maka
Status: COMPLETED
Conditions: Poverty
Interventions: BEHAVIORAL: Suubi-Maka ('Hope for Families')|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Omega-3 Fatty Acids on Sleep and Behavior (Pilot Study)
Status: COMPLETED
Conditions: Disturbances in Initiating and Maintaining Sleep|Behavior Problem
Interventions: DIETARY_SUPPLEMENT: Omega-3 fatty acids|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of the Transcranial Direct Current Stimulation (tDCS) on Dependent Smoking People
Status: UNKNOWN
Conditions: Tobacco Abuse Smoke
Interventions: DEVICE: transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Post-Marketing-Observational Study (PMOS) to Determine the Effectiveness of Combined Adalimumab Treatment and Active Supervised Training in Patients With Axial Spondyloarthritis (axSpA)
Status: TERMINATED
Conditions: Axial Spondyloarthritis
Interventions: BEHAVIORAL: Active Supervised Training (AST)|BEHAVIORAL: Standard of Care (SOC) Physiotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Systemic Sclerosis With Autologous Regulatory Т-cells
Status: UNKNOWN
Conditions: Systemic Sclerosis
Interventions: BIOLOGICAL: Autologous Regulatory Т-cells|OTHER: Standard treatment according to the clinical protocols
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blinatumomab in Treating Patients With B-cell Acute Lymphoblastic Leukemia With Minimal Residual Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Adult Acute Lymphoblastic Leukemia in Complete Remission|B Acute Lymphoblastic Leukemia|Minimal Residual Disease|Philadelphia Chromosome Positive
Interventions: BIOLOGICAL: Blinatumomab|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Persistence of Autoantibody Neutralisation by BC 007 in Patients With Chronic HFrEF and Autoantibodies Against the Beta1-Adrenergic Receptor
Status: COMPLETED
Conditions: Cardiomyopathy, Dilated|Heart Failure|Autoantibodies
Interventions: DRUG: BC 007
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sertraline and Habit Reversal in the Treatment of Patients With Trichotillomania
Status: COMPLETED
Conditions: Impulse Control Disorders
Interventions: DRUG: Sertraline|BEHAVIORAL: Habit Reversal Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fludarabine Phosphate, Busulfan, and Anti-Thymocyte Globulin Followed By Donor Peripheral Blood Stem Cell Transplant, Tacrolimus, and Methotrexate in Treating Patients With Myeloid Malignancies
Status: COMPLETED
Conditions: Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Blastic Phase Chronic Myelogenous Leukemia|Childhood Acute Myeloid Leukemia in Remission|Childhood Chronic Myelogenous Leukemia|Childhood Myelodysplastic Syndromes|Chronic Phase Chronic Myelogenous Leukemia|de Novo Myelodysplastic Syndromes|Hematopoietic/Lymphoid Cancer|Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Myeloid Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Relapsing Chronic Myelogenous Leukemia
Interventions: DRUG: fludarabine phosphate|DRUG: busulfan|BIOLOGICAL: anti-thymocyte globulin|DRUG: tacrolimus|DRUG: methotrexate|PROCEDURE: peripheral blood stem cell transplantation|PROCEDURE: allogeneic hematopoietic stem cell transplantation|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adebrelimab in Combination With Apatinib and Chemotherapy/Chemoradiotherapy in Immuno-experienced Second-line ESCC.
Status: NOT_YET_RECRUITING
Conditions: Esophageal Cancer
Interventions: DRUG: Adebrelimab|DRUG: Apatinib|DRUG: Investigator chosen chemotherapy (ICC)|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Demonstrate Equivalence of Sevelamer Carbonate Powder and Sevelamer HCl Tablets in Haemodialysis Patients
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: sevelamer carbonate (Renvela®) sevelamer hydrochloride (Renagel ®)|DRUG: sevelamer hydrochloride (Renagel ®) sevelamer carbonate (Renvela®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess the Safety, Tolerability and Pharmacokinetics of AZD2820 After Single Ascending Doses
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD2820|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Unrelated Cord Blood Transplant Plus a Haplo-Identical (Half-Matched), T-Cell Depleted Stem Transplant From a Related Donor for Subjects With High Risk Malignancies
Status: COMPLETED
Conditions: Hematologic Malignancy|Myelodysplastic Syndrome (MDS)|Aplastic Anemia
Interventions: BIOLOGICAL: haplo/cord transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Effectiveness of Interferon Alfa-2B Plus Didanosine in Patients With Kaposi's Sarcoma
Status: COMPLETED
Conditions: Sarcoma, Kaposi|HIV Infections
Interventions: DRUG: Interferon alfa-2b|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Patient Controlled Epidural Analgesia Versus Continuous Epidural Infusion: Obstetrical and Neonatal Outcomes
Status: UNKNOWN
Conditions: Pain
Interventions: DRUG: bupivicaine epidural|DRUG: bupivicaine epidural infusion patient epidural|DRUG: bupivicaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose:
Clinical trial: Statin Recapture Therapy Before Coronary Artery Bypass Grafting
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Statin Recapture Therapy|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Dexmedetomidine vs Propofol in Patients With Intra-abdominal Sepsis
Status: COMPLETED
Conditions: Septic Peritonitis
Interventions: DRUG: Midazolam|DRUG: Propofol|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Men Together Making a Difference: Health Promotion for Black Men
Status: COMPLETED
Conditions: HIV|Cardiovascular Disease|Diabetes|Hypertension|Colon Cancer
Interventions: BEHAVIORAL: Health Promotion Intervention|BEHAVIORAL: Health Awareness Control Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Narrow-band (NB)-UVB vs. Bath-PUVA and NB-UVB Plus Salt Water Baths in Atopic Dermatitis
Status: TERMINATED
Conditions: Atopic Dermatitis
Interventions: RADIATION: NB-UVB|RADIATION: Bath-PUVA|RADIATION: NB-UVB plus salt water baths
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Steroids, Hyaluronic Acid or Platelet Rich Plasma Versus Placebo for the Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Triamcort|DRUG: Platelet-rich-plasma|DRUG: Suplasyn1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retifanlimab (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients With Advanced Soft Tissue Sarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Soft Tissue Sarcoma|Sarcoma,Soft Tissue|Sarcoma|Soft Tissue Sarcoma Adult
Interventions: DRUG: Retifanlimab|DRUG: Gemcitabine|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home-based HIIT in a Primary-care Setting for at Risk Individuals: A Multidisciplinary Approach
Status: COMPLETED
Conditions: Risk Factor, Cardiovascular
Interventions: BEHAVIORAL: Home-based HIIT|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Trail of SARS-CoV-2 Bivalent mRNA Vaccine (LVRNA021) in Participants Aged 18 Years and Older
Status: RECRUITING
Conditions: SARS-CoV-2
Interventions: BIOLOGICAL: SARS-CoV-2 Bivalent mRNA vaccine (LVRNA021)|DRUG: 0.9% sodium chloride solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of LY3461767 in Participants With Chronic Heart Failure With Reduced Ejection Fraction
Status: COMPLETED
Conditions: Chronic Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: LY3461767|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Myomectomy for Intramural Myoma on Fertility Outcomes in Infertile Women
Status: UNKNOWN
Conditions: Infertility|Fibroid
Interventions: PROCEDURE: Myomectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgical Site Infection With 0.05% Chlorhexidine (CHG) Compared to Triple Antibiotic Irrigation
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Chlorhexidine irrigation|DRUG: triple antibiotic irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Retrospective Study to Evaluate the Predictability of Abnormal Arterial Blood Gas Measurements Through Novel Observations of Continuous Trends in Electronically Measured Respiratory Rate in a Mixed Cohort of Respiratory Compromised Patients
Status: UNKNOWN
Conditions: Respiratory Failure|COPD|Pneumonia|Community-acquired Pneumonia|COVID-19|Pulmonary Disease
Interventions: DEVICE: RespiraSense
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Topical Menthol Application in Chemotherapy-Related Peripheral Neuropathy in Patients With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Peripheral Neuropathies|Chemotherapy Effect
Interventions: OTHER: Menthol Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Longitudinal Quantitative Assessment of the Effectiveness of Metatarsal Pads on Plantar Pressures
Status: UNKNOWN
Conditions: Forefoot Callus|Podiatry|Foot Dermatoses|Keratosis
Interventions: DEVICE: Semi-compressed felt pad (SCF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ezetimibe Plus Simvastatin Versus Simvastatin in Patients With Hypercholesterolemia and Coronary Risk Factors (P03405)
Status: TERMINATED
Conditions: Hypercholesterolemia|Atherosclerosis
Interventions: DRUG: Ezetimibe|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Breakfast Nutrition and Inpatient Glycemia
Status: COMPLETED
Conditions: Diabetes, Type 1|Diabetes, Type 2|Cardiovascular Disease|Hyperglycemia
Interventions: OTHER: Modified Carbohydrate Breakfast|OTHER: Control Breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Vitamin D3 Supplementation in Dialysis Patients
Status: COMPLETED
Conditions: End-Stage Renal Disease
Interventions: DRUG: Cholecalciferol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of NTx®-265: Human Chorionic Gonadotropin (hCG) and Epoetin Alfa (EPO) in Acute Ischemic Stroke Patients
Status: TERMINATED
Conditions: Stroke
Interventions: DRUG: human chorionic gonadotropin (hCG), then epoetin alfa (EPO)|DRUG: human chorionic gonadotropin (hCG), then epoetin alfa (EPO)|DRUG: human chorionic gonadotropin (hCG), then epoetin alfa (EPO)|DRUG: Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Amantadine for the Treatment of Behavioral Disturbance in Frontotemporal Dementia (FTD)
Status: WITHDRAWN
Conditions: Dementia
Interventions: DRUG: Amantadine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Conventional Direct Laryngoscopy Vs. Video Laryngoscopy With The C-MAC For Pyloromyotomy
Status: TERMINATED
Conditions: Pyloric Stenosis|Intubation, Pediatric
Interventions: DEVICE: Video Laryngoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of Rectal Infiltration of Exparel for Analgesic Benefit Following Hemorrhoidectomy
Status: TERMINATED
Conditions: Hemorrhoid
Interventions: DRUG: Exparel|DRUG: Bupivacaine HCl with Epinephrine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Hypotonic Versus Isotonic Parenteral (HIP) Fluid Trial
Status: COMPLETED
Conditions: Hyponatremia|Hypernatremia
Interventions: DRUG: 0.9% NaCl|DRUG: 0.45%NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of Azilsartan Medoxomil Compared to Ramipril for Treating Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Azilsartan medoxomil|DRUG: Azilsartan medoxomil|DRUG: Ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Standard or Short-course Vonoprazan Non-bismuth Triple Therapy or High-dose Dual Therapy Versus Rabeprazole-bismuth Quadruple Therapy for Primary Helicobacter Pylori Eradication
Status: RECRUITING
Conditions: the Eradication Rates of Helicobacter Pylori
Interventions: DRUG: Rabeprazloe+bismuth+amoxicillin+clarithromycin|DRUG: Vonoprazan+amoxicillin+clarithromycin 14 days|DRUG: Vonoprazan+amoxicillin+clarithromycin 7 days|DRUG: Vonoprazan+tetracycline+furazolidone 14 days|DRUG: Vonoprazan+tetracycline+furazolidone 7 days|DRUG: Vonoprazan+amoxicillin+furazolidone 7 days|DRUG: Vonoprazan+amoxicillin+tetracycline 14 days|DRUG: Vonoprazan+amoxicillin 7 days|DRUG: Vonoprazan+amoxicillin 14 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Azacitidine and Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Adult Acute Megakaryoblastic Leukemia|Adult Acute Monoblastic Leukemia|Adult Acute Monocytic Leukemia|Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With Maturation|Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1|Adult Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3); MLLT3-KMT2A|Adult Acute Myeloid Leukemia Without Maturation|Adult Acute Myelomonocytic Leukemia|Adult Erythroleukemia|Adult Pure Erythroid Leukemia|Secondary Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|DRUG: Gemtuzumab Ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Lasmiditan in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lasmiditan|DRUG: Dabigatran Etexilate|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Malaria Diagnostic Testing and Conditional Subsidies to Target ACTs in the Retail Sector: the TESTsmART Trial AIM 1
Status: COMPLETED
Conditions: Malaria|Febrile Illness
Interventions: OTHER: Conditional ACT subsidy, Arm 1 levels|OTHER: Conditional ACT subsidy, Arm 2 levels|OTHER: Conditional ACT subsidy, Arm 3 levels|OTHER: Conditional ACT subsidy, Arm 4 levels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Patient Outcomes From Second Film-readers and Test Threshold Relaxation in Breast Screening
Status: ENROLLING_BY_INVITATION
Conditions: Breast Cancer|Ductal Carcinoma in Situ
Interventions: DIAGNOSTIC_TEST: Breast Screening Mammography with single reader|DIAGNOSTIC_TEST: Breast screening mammography with two readers|DIAGNOSTIC_TEST: Test threshold
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Absorption, Distribution, Metabolism and Excretion of [14C]-Labelled BIA 3-202 and Metabolites
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: BIA 3-202 (200 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Safety of Nintedanib in Combination With Nivolumab in Pretreated Patients With Advanced or Metastatic NSCLC of Adenocarcinoma Histology
Status: COMPLETED
Conditions: Adenocarcinoma of the Lung
Interventions: DRUG: nintedanib-nivolumab combination therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Availability of Vitamin D in Orange Juice
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D2 in orange juice|DIETARY_SUPPLEMENT: Vitamin D3 in orange juice|DIETARY_SUPPLEMENT: Vitamin D2|DIETARY_SUPPLEMENT: Vitamin D3|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of SKLB1028 Versus Salvage Chemotherapy in Patients With Relapsed or Refractory (R/R) AML With FLT3-Mutated
Status: RECRUITING
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: SKLB1028|DRUG: Salvage Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of Positive Psychotherapy for Smoking Cessation
Status: COMPLETED
Conditions: Smoking
Interventions: BEHAVIORAL: Positive Psychotherapy for smoking cessation|DRUG: Nicotine polacrilex|BEHAVIORAL: Relaxation training|BEHAVIORAL: Behavioral smoking cessation treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Natural History Study of Corneal Abrasions in Patients With Dystrophic Epidermolysis Bullosa (DEB)
Status: RECRUITING
Conditions: Epidermolysis Bullosa Dystrophica|Epidermolysis Bullosa Dystrophica, Recessive|Epidermolysis Bullosa Dystrophica Dominans
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tivantinib in Treating Patients With Relapsed, or Relapsed and Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Refractory Multiple Myeloma
Interventions: DRUG: Tivantinib|OTHER: Diagnostic laboratory biomarker analysis|OTHER: Questionnaire administration|PROCEDURE: Quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Coach for Adolescents With Type 1 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Type 1 Diabetes
Interventions: BEHAVIORAL: Sleep Coach|BEHAVIORAL: Diabetes Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemerin and Interleukin-6 Levels of Gingival Crevicular Fluid in Obese Individuals Following Periodontal Treatment
Status: COMPLETED
Conditions: Obesity|Periodontitis
Interventions: OTHER: Non-surgical periodontal treatment|OTHER: Gingival crevicular fluid collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endocardial Vs Epicardial Ablation for Recurrent Paroxysmal AF
Status: WITHDRAWN
Conditions: Recurrent Paroxysmal Atrial Fibrillation Despite Prior Pulmonary Vein Isolation
Interventions: DEVICE: Endocardial PVI|DEVICE: Epicardial Posterior Wall Isolation + LAA Exclusion + Endocardial PVI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4144 Following Single and Multiple Ascending Doses Via Oral Administration to Healthy Participants
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: AZD4144 Part A|DRUG: AZD4144 Part B|DRUG: Placebo Part A|DRUG: Placebo Part B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drug Screening Using IMD in Bladder Cancer
Status: NOT_YET_RECRUITING
Conditions: Muscle Invasive Bladder Urothelial Carcinoma
Interventions: DEVICE: Implantable Micro-Device|DRUG: Methotrexate|DRUG: Carboplatin|DRUG: Avelumab|DRUG: Paclitaxel|DRUG: Vinblastine|DRUG: Gemcitabine/Cisplatin I|DRUG: Methotrexate/Vinblastine/Doxorubicin/Cisplatin/Avelumab|DRUG: Gemcitabine/Cisplatin II|DRUG: Cisplatin|DRUG: Nivolumab|DRUG: Pembrolizumab|DRUG: Gemcitabine/Carboplatin|DRUG: Methotrexate/Vinblastine/Doxorubicin/Cisplatin|DRUG: Gemcitabine/Cisplatin/Nivolumab|DRUG: Erdafitinib|DRUG: Paclitaxel/Docetaxel/Ifosfamide|DRUG: Gemcitabine|DRUG: Gemcitabine/Carboplatin/Nivolumab|DRUG: Enfortumab|DRUG: Sacituzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic and Perfusion Response to Drotrecogin Alfa (Activated) in Patients With Septic Shock
Status: COMPLETED
Conditions: Sepsis|Septic Shock
Interventions: DRUG: drotrecogin alfa (activated)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predicting Responses to PTSD Treatment With Iris and Cardiovascular Tests
Status: RECRUITING
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: Prazosin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Exercise on Cardiometabolic Profile in Women With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: BEHAVIORAL: Exercise Intervention|BEHAVIORAL: Lifestyle Physical Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomisation to Endobarrier Alone Versus With Incretin Analogue in SustainEd Diabesity (REVISE-Diabesity)
Status: UNKNOWN
Conditions: Type 2 Diabetes|Obesity|Diabesity
Interventions: DRUG: Liraglutide|DEVICE: Duodenal-jejunal bypass liner - Endobarrier device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Costs of Lost Productive Time Among Korean Workers With Panic Disorder and Effect of Treatment With Paroxetine Controlled Release
Status: UNKNOWN
Conditions: Panic Disorder
Interventions: DRUG: Paroxetine CR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Purified Poloxamer 188 in Vaso-Occlusive Crisis of Sickle Cell Disease (EPIC)
Status: COMPLETED
Conditions: Vaso-occlusive Crisis|Sickle Cell Disease
Interventions: DRUG: Saline|DRUG: MST-188
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Different Intensities of Bilateral- and Cathodal-tDCS in Healthy Individuals
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Bilateral-Transcranial direct current stimulation (bilateral-tDCS)|DEVICE: Cathodal-Transcranial direct current stimulation (cathodal-tDCS)|DEVICE: Sham bilateral-tDCS|DEVICE: Sham cathodal-tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nicotine Withdrawal Symptoms and Smoking Relapse
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: DEVICE: Transcranial Direct Current Stimulation|DEVICE: sham|DRUG: Nicotine patch|DRUG: Placebo patch|DRUG: Varenicline Pill|DRUG: Placebo pill|BEHAVIORAL: Motivational Interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Glucocorticoid Combined With Vitamin C and Vitamin B1 on Microcirculation in Severe Septic Shock
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: Glucocorticoid combination therapy|DRUG: Glucocorticoid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of the Direct Renin Inhibitor Aliskiren on Endothelial Function and Arterial Stiffness in Diabetic Subjects
Status: TERMINATED
Conditions: Diabetes|Pre-hypertension|Hypertension
Interventions: DRUG: aliskiren 300 mg once daily|DRUG: Placebo/sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Venous Thromboembolism (VTE) Treatment Study in Japanese Pulmonary Embolism (PE) Patients
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)|DRUG: Unfractionated heparin|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Ischemic Postconditioning on Targeting of Annexin A5 After Forearm Exercise
Status: WITHDRAWN
Conditions: Cardiovascular Disease|Ischemia-reperfusion Injury|Postconditioning
Interventions: PROCEDURE: repetitive short ischemia and reperfusion of non dominant fore arm after 10 minute ischemic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Reason to Season; Flavors to Increase Vascular Health
Status: COMPLETED
Conditions: Overweight and Obesity|Healthy
Interventions: OTHER: Breakfast: control meal|OTHER: Breakfast: Cinnamon meal|OTHER: Breakfast: Italian herbs meal|OTHER: Breakfast: pumpkin spice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Efficacy of Cyclosporine Ophthalmic Emulsion in the Treatment of Dry Eye Syndrome in Contact Lens Wearers
Status: COMPLETED
Conditions: Contact Lens Wearers With Dry Eye Syndrome
Interventions: DRUG: cyclosporine ophthalmic emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Multifocal Chromatic Pupilloperimetry in Patients With Pseudotumor Cerebri and Healthy Subjects.
Status: RECRUITING
Conditions: Pseudotumor Cerebri
Interventions: DIAGNOSTIC_TEST: objective chromatic multifocal pupillometer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Open-Label Study of Oral NNZ-2591 in Prader-Willi Syndrome (PWS-001)
Status: SUSPENDED
Conditions: Prader-Willi Syndrome
Interventions: DRUG: NNZ-2591
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-compassion Therapist-led Online Group Treatment for Adolescents With Distress, Anxiety, and Depression
Status: RECRUITING
Conditions: Distress, Emotional|Anxiety|Depression
Interventions: BEHAVIORAL: Compassion focused group therapy online
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Specific Verbal vs. Usual Instructions for Inpatients Undergoing Colonoscopy
Status: UNKNOWN
Conditions: Adequate Colonoscopy Preparation for Inpatients
Interventions: PROCEDURE: SPECIFIC VERBAL INSTRUCTIONS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Hemofiltration in Burns: RESCUE (Randomized Controlled Evaluation of Hemofiltration in Adult Burn Patients With Septic Shock and Acute Renal Failure)
Status: UNKNOWN
Conditions: Burns|Hemofiltration|Kidney Failure, Acute|Shock, Septic
Interventions: DEVICE: An FDA approved continuous renal replacement device|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cellulite and Extracorporeal Shock Wave
Status: COMPLETED
Conditions: Cellulite|Microcirculation
Interventions: DEVICE: Extracorporeal shockwave therapy|DEVICE: Sham extracorporeal shock wave plus gluteal strength exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Sugar Sweetened Beverage on Metabolic Health in Male and Female Adolescents
Status: COMPLETED
Conditions: Insulin Sensitivity|Insulin Tolerance
Interventions: DIETARY_SUPPLEMENT: high fructose sweetened beverage|DIETARY_SUPPLEMENT: High Glucose sweetened beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study Comparing CRx-102 Plus Disease-modifying Anti-rheumatic Drug (DMARD) Therapy to Placebo Plus DMARD Therapy in RA
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: CRx-102|DRUG: Placebo|DRUG: DMARD Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Temporal Window and Episodic Future Thinking in CUD
Status: RECRUITING
Conditions: Cocaine Use Disorder
Interventions: BEHAVIORAL: Episodic Future Thinking (EFT)|BEHAVIORAL: Control Episodic Thinking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Core Versus on Tennis Serve Velocity in Young Adult Tennis Players
Status: RECRUITING
Conditions: Tennis Elbow
Interventions: OTHER: Core Strengthening Programs|OTHER: Shoulder Strengthening Programs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Randomized Trial of Electronic Cigarettes With or Without Nicotine in Smoking Cessation.
Status: UNKNOWN
Conditions: Smoking Cessation|Smoking, Cigarette|Electronic Cigarette
Interventions: DRUG: Electronic cigarette without nicotine (ECwN) plus active varenicline tablets|DRUG: Electronic cigarette without nicotine (ECwoN) plus placebo tablets of varenicline|DRUG: Electronic cigarette with nicotine (ECwN) plus placebo tablets of varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of ssCART-19 Cell Injection in the Treatment of Relapsed or Refractory Acute Lymphoblastic Leukemia (Including Central Nervous System Infiltration)
Status: NOT_YET_RECRUITING
Conditions: Relapsed or Refractory Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: ssCART-19|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mid-term Data Collection of the Treatment of Intracranial Aneurysms With the WEB™ Aneurysm Embolization System
Status: WITHDRAWN
Conditions: Ruptured and Unruptured Intracranial Aneurysms
Interventions: DEVICE: WEB aneurysm embolization system
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of a Dietary Supplement (Aqualief®) in Xerostomic Patients
Status: COMPLETED
Conditions: Xerostomia Due to Hyposecretion of Salivary Gland|pH|Saliva|Quality of Life
Interventions: DIETARY_SUPPLEMENT: Aqualief|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intracorporeal Vs Extracorporeal Anastomosis in Laparoscopic Right Hemicolectomy
Status: COMPLETED
Conditions: Colorectal Surgery|Anastomotic Leak|Colectomy|Laparoscopy
Interventions: PROCEDURE: Right hemicolectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tinidazole for Recurrent Bacterial Vaginosis: A Pilot Study
Status: COMPLETED
Conditions: Bacterial Vaginosis
Interventions: DRUG: tinidazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Magnetically Navigated vs. Manually Guided Radiofrequency in Atrioventricular-node-reentry-tachycardia
Status: COMPLETED
Conditions: Atrioventricular Nodal Reentry Tachycardia|Radiofrequency Ablation
Interventions: PROCEDURE: RF-ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PEPI-TiDP23-C104 is a First in Human Study With a Single Dose Escalation Part and a Multiple Dosing Part for Compounds TMC589337 and TMC589354.
Status: WITHDRAWN
Conditions: HIV Infections
Interventions: DRUG: TMC589337 40 mg|DRUG: TMC589337 100 mg|DRUG: TMC589337 200 mg|DRUG: TMC589337 400 mg|DRUG: TMC589354 40 mg|DRUG: TMC589354 100 mg|DRUG: TMC589354 200 mg|DRUG: TMC589354 400 mg|DRUG: TMC589337 AA mg|DRUG: TMC589354 BB mg|DRUG: TMC589337 CC mg|DRUG: TMC589354 DD mg|DRUG: TMC589337 EE mg|DRUG: TMC589354 YY mg|DRUG: TMC310911 300 mg|DRUG: TMC310911 600 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Endostar Combined With AI Regimen Compared With AI in Adjuvant Treatment
Status: UNKNOWN
Conditions: Other Disorders of Soft Tissues
Interventions: DRUG: Endostar (recombinant human endostatin injection)|DRUG: Chemotherapy AI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: AMX0035 in Patients With Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis|Motor Neuron Disease|Neuromuscular Diseases|Neurodegenerative Diseases|Spinal Cord Diseases|TDP-43 Proteinopathies|Nervous System Diseases|Central Nervous System Diseases
Interventions: DRUG: AMX0035|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biphasic Calcium Phosphate vs. Hydroxyapatite in Sinus Floor Elevation
Status: COMPLETED
Conditions: Bone Substitutes|Calcium Phosphates|Hydroxyapatite|Rhodophyta|Sinus Floor Augmentation
Interventions: DEVICE: Use of Symbios Bone Graft Material|DEVICE: Algipore Bone Substitution Material
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT