pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Airway Interventions During Intravenous Anesthesia in Children Undergoing Direct Laryngoscopy for Surgical Procedures Using High Flow Nasal Versus Low Flow Oxygen. A Pilot Study.(Flowkid)
Status: RECRUITING
Conditions: Laryngoscopy|Child|Oxygen Therapy
Interventions: DEVICE: low flow oxygen with nasopharyngeal tube|DEVICE: high flow oxygen with OptiflowTM Nasal High Flow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Safety and Immunogenicity of VPM1002 in Comparison With BCG in HIV-exposed/-Unexposed Newborn Infants in South Africa
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: VPM1002|BIOLOGICAL: BCG|BIOLOGICAL: VPM1002(Hyg+)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The 1000 First Day of Life : Effect of Multi Micronutrients Supplementation on Pregnancy Outcomes
Status: RECRUITING
Conditions: Maternal Care Patterns|Nutrition, Healthy|Nutritional Deficiency|Maternal-Fetal Relations|Perinatal Outcome|Maternal Outcome
Interventions: DIETARY_SUPPLEMENT: Multiple Micronutrients during pregnancy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Open Label, Phase III Study of NABI-IGIV 10% [Immune Globulin Intravenous(Human), 10%] In Subjects With Primary Immune Deficiency Disorders (PIDD)
Status: COMPLETED
Conditions: Primary Immune Deficiency Disorders (PIDD)
Interventions: BIOLOGICAL: Nabi-IGIV 10% [Immune Globulin Intravenous (Human). 10%]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xylitol and Sorbitol Effects on the Oral Microbiome
Status: COMPLETED
Conditions: Human Microbiome
Interventions: OTHER: Xylitol then Sorbitol gum|OTHER: Sorbitol then Xylitol gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Maxillo-facial Treatment on Cleft Lip and Palate Patients Faces: Aesthetic Considerations
Status: COMPLETED
Conditions: Cleft Lip and Palate|Growth and Development|Cicatrix|Randomized Controlled Trial
Interventions: OTHER: VAS scale (from 1 to 10) esthetic assessment of facial 3-D images
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lenalidomide and Temsirolimus in Treating Patients With Previously Treated Multiple Myeloma
Status: COMPLETED
Conditions: Refractory Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma
Interventions: DRUG: lenalidomide|DRUG: temsirolimus|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Mindfulness Meditation on Rhinoplasty Outcomes
Status: WITHDRAWN
Conditions: Nose Deformity
Interventions: OTHER: Mindfulness Pain Management Arm|OTHER: Mindfulness Self Esteem Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CALLS: CML and Ph+ALL Low Level Mutation Prevalence Survey
Status: COMPLETED
Conditions: Chronic Phase Chronic Myelogenous Leukemia|Accelerated Phase Chronic Myelogenous Leukemia|Blastic Phase Chronic Myelogenous Leukemia|Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Subacute Thyroiditis in the SARS-CoV-2 Era
Status: COMPLETED
Conditions: Subacute Thyroiditis|SARS CoV 2 Infection|Thyrotoxicosis
Interventions: DIAGNOSTIC_TEST: Blood sample, CRF, thyroid ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: BGM and HbA1c POC Device Evaluation
Status: RECRUITING
Conditions: Diabetes
Interventions: DIAGNOSTIC_TEST: CareSens N-Eco (i-Sens), • CareSens N-Premier (i-Sens), CodeFree (SD Biosensor), GlucoNavii GDH (SD Biosensor)|DIAGNOSTIC_TEST: Affinion (Abbott), HbA1c 501 (HemoCue), A1Care (iSens), DCA Vantage (Siemens)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Randomized Trial Comparing Conventional Radiotherapy With Stereotactic Radiotherapy in Patients With Bone Metastases - VERTICAL Study
Status: COMPLETED
Conditions: Spinal Metastases|Bone Metastases
Interventions: RADIATION: Stereotactic Body Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Chiropractic Treatment of Infantile Colic
Status: COMPLETED
Conditions: Infantile Colic
Interventions: OTHER: Chiropractic treatment|OTHER: Visit without active treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Magnetic Resonance Features and Outcomes of Patients With Non-Compaction Cardiomyopathy - a Retrospective Follow-up From Pakistan
Status: COMPLETED
Conditions: Left Ventricle Non-compaction Cardiomyopathy
Interventions: OTHER: Patients were retrospectively enrolled. This was a retrospective study and no intervention was performed.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Venetoclax + Cytarabine Versus Idarubicin + Cytarabine : Efficacity Assessment as Post-remission Therapy to Elderly Patients With Acute Myeloid Leukemia in First Remission
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Cytarabine-Venetoclax Association|DRUG: Cytarabine-Idarubicin Association
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Meperidine and Sufentanil Added to 0.5% Hyperbaric Bupivacaine for Spinal Anesthesia in Cesarean Section
Status: UNKNOWN
Conditions: Analgesia
Interventions: DRUG: sufentanil|DRUG: meperidine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Optos Versus Indirect Ophthalmoscopy for ROP Screening Examination (Optos vs BIO Study)
Status: COMPLETED
Conditions: Pre-Term
Interventions: DIAGNOSTIC_TEST: Optos ultra-widefield retinal imaging (Optos California)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: An Open Label Trial of Omega 3(o3mega+Joy)in the Treatment of Social Phobia
Status: COMPLETED
Conditions: Social Anxiety Disorder
Interventions: DRUG: Omega 3 Joy enteric coated concentrated fish oil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spina Plane Block Versus Deep Serratus Anterior Plane Block for Post Mastectomy Analgesia
Status: COMPLETED
Conditions: MASTECTOMY
Interventions: PROCEDURE: Erector spina plain block for mastectomy analgesia|PROCEDURE: Deep serratus anterior plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Passive Joint Mobilization vs Mobilization With Movement on Pain Processing in Patients With Chronic Low Back Pain
Status: UNKNOWN
Conditions: Chronic Low-back Pain
Interventions: OTHER: Passive joint mobilization|OTHER: Mobilization with movement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DTPACE Followed by Tandem Transplant With Melphalan (MEL) 200 Versus MEL/Dexamethasone/Thalidomide (DT) Platinol/Adriamycin/Etoposide (PACE) Hybrid and DTPACE Consolidation
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Cisplatin|DRUG: Cyclophosphamide|DRUG: Adriamycin|DRUG: Etoposide|DRUG: Melphalan|DRUG: Thalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Lower Extremity Joint Manipulation on a Lower Extremity Somatosensory Illusion
Status: COMPLETED
Conditions: Coordination and Balance Disturbances|Healthy
Interventions: OTHER: chiropractic manual therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Safety and Effectiveness of BELKYRA® Inj. for the Treatment of Patients With Submental Fullness Due to Submental Fat: A Postmarketing Surveillance Study in Korea
Status: TERMINATED
Conditions: Submental Fullness
Interventions: DRUG: BELKYRA Inj.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chemotherapy of Elderly Patients With Non-Small-Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: NSCLC
Interventions: DRUG: Paclitaxel + Carboplatin|DRUG: Monotherapy (gemcitabine or vinorelbine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Effects of Synbiotic on Gut Microbiota Composition in Scholars With Overweight
Status: COMPLETED
Conditions: Childhood Obesity|Childhood Overweight
Interventions: DIETARY_SUPPLEMENT: Lactobacillus casei strain Shirota|DIETARY_SUPPLEMENT: Lactobacillus casei strain Shirota plus inulin|DIETARY_SUPPLEMENT: Lactobacillus casei strain Shirota plus fructans from A. salmiana
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: C Reactive Protein in Home Quarantined Coronavirus Disease 2019 (COVID -19) Patients.
Status: COMPLETED
Conditions: COVID -19
Interventions: DRUG: Oral Antibiotic, Antihistamine, Anti-inflammatory, Multivitamins|DRUG: Oral low dose steroid|DRUG: Intravenous Antibiotics with Low dose steroid.|DRUG: Oral anti-coagulant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pembrolizumab in Combination With Platinum-Based Chemotherapy in Non-Small Cell Lung Cancer (NSCLC) Patients With Targetable Genetic Alterations, Previously Treated With Appropriate Targeted Agents, With Progressive Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Carboplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Natural Killer (NK) Cell Based Adoptive Immunotherapy for the Treatment of Patients With Non-Small Cell Lung Cancer (NSCLC) After Radiochemotherapy (RCT)
Status: COMPLETED
Conditions: NSCLC Stage IIIA/B
Interventions: OTHER: Hsp70-peptide TKD/IL-2 activated, autologous NK cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expanded Access for ABI-009 in Patients With Advanced PEComa and Patients With a Malignancy With Relevant Genetic Mutations or mTOR Pathway Activation
Status: APPROVED_FOR_MARKETING
Conditions: PEComa, Malignant|TSC1|TSC2|mTOR Pathway Abberation
Interventions: DRUG: ABI-009
Study Type: EXPANDED_ACCESS
Clinical trial: A Phase 2a Study to Evaluate Viral Kinetics and Safety of Telaprevir in Participants With Genotype 2 or 3 Hepatitis C Infection
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Telaprevir|DRUG: Peg-IFN-alfa-2a + Ribavirin (Standard Treatment)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Modulating Inhibitory Control Networks in Gambling Disorder With Theta Burst Stimulation
Status: RECRUITING
Conditions: Gambling Disorder
Interventions: DEVICE: Transcranial Magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Alpha-Stim Cranial-electrotherapy Stimulation (CES) in the Treatment of Anxiety
Status: COMPLETED
Conditions: Anxiety
Interventions: DEVICE: CES treatment using Alpha-Stim technology|DEVICE: Shame CES Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Transmedial Psychoeducational Program to Improve Pharmacological Adherence
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DEVICE: Transmedial Psychoeducational Program to improve adherence full or partial (PS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prolonged Release Pirfenidone for Advanced Residual Liver Fibrosis (MINERVA).
Status: RECRUITING
Conditions: Liver Cirrhosis|Hepatitis C, Chronic|Epigenetic Disorder
Interventions: DRUG: Prolonged-Release Pirfenidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise
Status: RECRUITING
Conditions: Aging|Blood Pressure|Endothelial Dysfunction|Hypertension
Interventions: OTHER: High-resistance inspiratory muscle strength training|OTHER: Aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Renal Perfusion, Filtration and Oxygenation After Liver Transplantation -Effects of av Postoperative Blood Pressure
Status: COMPLETED
Conditions: Acute Kidney Injury|Liver Failure
Interventions: OTHER: Alternating mean arterial pressure|DRUG: Norepinephrine|DRUG: Chromium ethylenediaminetetraacetic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In-Bed Cycling in ICU Patients Post Cardiac Surgery
Status: COMPLETED
Conditions: Cardiac Disease|Critical Illness|Critical Illness Polyneuropathy|Critical Illness Myopathy|Thoracic Surgery
Interventions: OTHER: In-Bed Cycling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enteric-coated Mycophenolate Sodium Versus Azathioprine for the Extra-renal Lupus Manifestations
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Azathioprine|DRUG: Enteric-Coated Mycophenolate Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Systematically Intermittent Arm Exercise for Improving Maturation of Hemodialysis Arteriovenous Shunt: Study Protocol for a Randomized Controlled Trial
Status: COMPLETED
Conditions: Systematically Intermittent Arm Exercise for Improving Maturation of Hemodialysis Arteriovenous Shunt
Interventions: OTHER: Systematically intermittent arm exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Induction Tislelizumab Combined With Chemotherapy Followed by Definitive Chemoradiotherapy in the Treatment of Locally Unresectable Esophageal Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Immunotherapy Esophagus Cancer
Interventions: DRUG: Tislelizumab|DRUG: Albumin paclitaxel|DRUG: Nedaplatin|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vanguard Knee Anterior Stabilized Versus Posterior Stabilized Bearing Study
Status: WITHDRAWN
Conditions: Osteoarthritis|Degenerative Arthritis
Interventions: DEVICE: Vanguard Knee System with AS Bearing|DEVICE: Vanguard Knee System with PS Bearing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AB-2100, an Integrated Circuit T (ICT) Cell Therapy in Patients With Recurrent Clear-cell Renal Cell Carcinoma (ccRCC)
Status: RECRUITING
Conditions: Advanced/Metastatic Clear Cell Renal Cell Carcinoma|Recurrence
Interventions: BIOLOGICAL: AB-2100
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of VET3-TGI in Patients With Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Solid Tumor, Adult|Microsatellite Stable Colorectal Cancer|Head and Neck Squamous Cell Carcinoma|Cervical Cancer|Kidney Cancer|Renal Cell Carcinoma|Melanoma Stage IV|Merkel Cell Carcinoma of Skin|Mesothelioma|Non-small Cell Lung Cancer
Interventions: DRUG: VET3-TGI|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Response to Chemotherapy by Adding Physical Exercise in the Neoadjuvant Setting of Breast Cancer Patients
Status: RECRUITING
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Combined Aerobic and Resistance Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The WISE Trial - Walking Improvement for SCI With Exoskeleton
Status: COMPLETED
Conditions: Injuries, Spinal Cord
Interventions: DEVICE: Ekso GT Rehabilitation Therapy|DEVICE: Body Weight Supported (BWS) Treadmill Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Positive Airway Pressure (CPAP) Pediatric Patients With Subglottic Stenosis Who Undergo Balloon Dilatation
Status: COMPLETED
Conditions: Airway Complication of Anesthesia|Congenital Subglottic Stenosis
Interventions: PROCEDURE: CPAP group: postoperative CPAP support, non-CPAP group: oxygen 3 liters per minute (L/min) either via mask for those who were extubated or through a T-piece for those with a trash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Learn About the Medicine (PF-07321332 or Nirmatrelvir/Ritonavir) in Healthy Lactating Women
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: nirmatrelvir|DRUG: ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of APD356 (Lorcaserin) in Healthy Japanese Adult Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: APD356 10 mg|DRUG: APD356 XR-20 mg|DRUG: APD356 10 mg matching Placebo|DRUG: APD356 XR-20 mg matching Placebo|DRUG: APD356 20 mg|DRUG: APD356 20 mg matching Placebo|DRUG: APD356 XR-20 mg (orange tablet)|DRUG: APD356 XR-20mg (orange tablet, fed state)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Alternative Schedule Sunitinib in Metastatic Renal Cell Carcinoma: Cardiopulmonary Exercise Testing
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Sunitinib|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Different Lens Treatments on Chinese Adolescent Myopia
Status: UNKNOWN
Conditions: Progressive Myopia
Interventions: OTHER: Spectacles|OTHER: Myovision|OTHER: Orthokeratology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Examining the Short and Long-term Effect of Myofascial Trigger Points Injection in Low Back Pain Patients
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: Bupivacaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Whole-body Photobiomodulation on Muscular Performance Enhancement.
Status: COMPLETED
Conditions: Sports Performance|Injury Prevention|Muscle Damage|Musculoskeletal Pain
Interventions: OTHER: Muscle damage protocol training|DEVICE: Photobiomodulation therapy (PBMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of V934/V935 Vaccine in Cancer Participants With Selected Solid Tumors (V934-002)
Status: COMPLETED
Conditions: Non-Small Cell Lung Carcinoma|Breast Cancer|Melanoma|Upper GI Tract Carcinoma|Colon Carcinoma|Renal Cell Carcinoma|Bladder Carcinoma|Prostate Cancer
Interventions: BIOLOGICAL: V935|BIOLOGICAL: V934-EP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemoradiation Plus Tislelizumab for Conversion Therapy of Locally Nonresectable ESCC
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma|Tislelizumab|Chemoradiation
Interventions: DRUG: Tislelizumab|DRUG: Paclitaxel|DRUG: Carboplatin|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Diagnosis and Management of CLL in Italy by GIMEMA
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|MBL-CLL - Monoclonal B-Cell Lymphocytosis Chronic Lymphocytic Leukaemia-Type
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Pharmacology Study of Brentuximab Vedotin (SGN-35)
Status: COMPLETED
Conditions: Carcinomas|Disease, Hodgkin|Lymphoma, Large-Cell, Anaplastic|Lymphoma, Non-Hodgkin|Neoplasms
Interventions: DRUG: brentuximab vedotin|DRUG: rifampin|DRUG: midazolam|DRUG: ketoconazole|DRUG: brentuximab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Dose Finding Study of DTX101 (AAVrh10FIX) in Adults With Moderate/Severe to Severe Hemophilia B
Status: TERMINATED
Conditions: Hemophilia B
Interventions: GENETIC: DTX101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Pharmacokinetics Study of ASP0456 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy|Pharmacokinetics of ASP0456
Interventions: DRUG: ASP0456|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Treatment of Ulcerative Colitis With Ciprofloxacin and E. Coli Nissle
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Ciprofloxacin|DIETARY_SUPPLEMENT: E. coli Nissle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of HFR-SUPRA in the Treatment of Multiple Myeloma-related Acute Kidney Injury
Status: NOT_YET_RECRUITING
Conditions: Multiple Myeloma|Acute Kidney Injury|Hemodiafiltration With Ultrafiltrate Regeneration (HFR)
Interventions: PROCEDURE: HFR-SUPRA|PROCEDURE: hemodialysis|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Elastic Band Resistance Training on Physical Fitness and Risk of Falls in Elderly.
Status: WITHDRAWN
Conditions: Falls|Old Age; Debility|Hospitalisation|Resistance Training|Physical Fitness
Interventions: BEHAVIORAL: elastic-band exercises|BEHAVIORAL: regular rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of MLN6907 in Patients With Metastatic Colorectal
Status: COMPLETED
Conditions: Imaging of Solid Gastrointestinal Tumors
Interventions: DRUG: [68Ga]MLN6907
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Epacadostat and Vaccine Therapy in Treating Patients With Stage III-IV Melanoma
Status: COMPLETED
Conditions: Mucosal Melanoma|Recurrent Melanoma|Recurrent Uveal Melanoma|Stage IIIA Skin Melanoma|Stage IIIA Uveal Melanoma|Stage IIIB Skin Melanoma|Stage IIIB Uveal Melanoma|Stage IIIC Skin Melanoma|Stage IIIC Uveal Melanoma|Stage IV Skin Melanoma|Stage IV Uveal Melanoma
Interventions: DRUG: Epacadostat|BIOLOGICAL: MELITAC 12.1 Peptide Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Subconjunctival 5-Fluorouracil (FU) Injection and Mitomycin C for Treatment of Early Bleb Failure
Status: UNKNOWN
Conditions: Bleb
Interventions: DRUG: 5-FU and Mitomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Modafinil, Caffeine and Methylphenidate in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Methylphenidate 20 mg tablet given once by mouth|DRUG: modafinil 200mg tablet given once by mouth|DRUG: caffein 200mg tablet given once by mouth|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacodynamic Effects, Safety and Tolerability of Cilobradine, to Healthy Male and Female Volunteers, With an Intra-individual Comparison to Moxifloxacin in a Subset of Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cilobradine, low, film-coated tablets|DRUG: Cilobradine, high, film-coated tablets|DRUG: Placebo, film-coated tablets|DRUG: Moxifloxacin, film-coated tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Darolutamide Treatment in the Triple Therapy of mHSPC
Status: RECRUITING
Conditions: Metastatic Prostate Cancer|Intermitent Anti-androgen Therapy
Interventions: DRUG: Darolutamide continuous|DRUG: Darolutamide intermittent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraductal Transanastomotic Stent in Duct-to-duct Biliary Reconstruction in Liver Transplantation
Status: ENROLLING_BY_INVITATION
Conditions: Liver Transplant; Complications
Interventions: PROCEDURE: Intraductal transanastomotic stent group|PROCEDURE: No stent group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaginal Isonicotinic Acid Hydrazide Administration Prior to Intrauterine Device Insertion
Status: COMPLETED
Conditions: IUCD Complication
Interventions: DRUG: INH|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Sugammadex (Org 25969, MK-8616) in Participants With or Having a Past History of Pulmonary Disease (19.4.308) (P05932) (MK-8616-017)
Status: COMPLETED
Conditions: Anesthesia, General
Interventions: DRUG: Sugammadex|DRUG: Rocuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel in Non Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Carcinoma, Squamous Cell
Interventions: DRUG: Docetaxel + CDDP|DRUG: docetaxel + CDDP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib and Fludarabine With or Without Rituximab in Treating Patients With Relapsed or Refractory Indolent Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hematopoietic/Lymphoid Cancer|Nodal Marginal Zone B-cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Splenic Marginal Zone Lymphoma|Waldenström Macroglobulinemia
Interventions: DRUG: bortezomib|DRUG: fludarabine phosphate|BIOLOGICAL: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Polyvinyl Alcohol Sodium Acrylate Embolization Microspheres for CRLM
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer Liver Metastasis
Interventions: DEVICE: Irinotecan and polyvinyl alcohol sodium acrylate embolization microspheres（Unipearls®）|DEVICE: Irinotecan and HepaSphere Microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Three Oral Devices as Mouthguard in Electroconvulsive Therapy. Randomized Crossover Clinical Trial.
Status: TERMINATED
Conditions: Temporomandibular Joint Dysfunction Syndrome|Tooth Injuries|Dental Occlusion, Traumatic
Interventions: DEVICE: Solubrux®|DEVICE: Customized Appliance|DEVICE: Somatics®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Trial to Investigate the Safety, Tolerability and Pharmacokinetics of Intravenous SPM 927
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: iv SPM 927 and oral placebo tablet|DRUG: oral SPM 927 tablet and iv placebo|DRUG: iv SPM 927 and oral placebo tablet|DRUG: oral SPM 927 tablet and iv placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ECI301 and Radiation for Advanced or Metastatic Cancer
Status: TERMINATED
Conditions: Cancer|Neoplasm Metastasis|Radiation Oncology|Neoplasm|Metastasis
Interventions: PROCEDURE: Radiation Therapy|DRUG: ECI301
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proposal To Develop A Rapid And Cost-Effective Diagnostic Test For Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DRUG: Ziprasidone|DRUG: Olanzapine|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Expedited Versus Restrictive: Limitations on Activity Following Surgical Treatment of Prolapse
Status: COMPLETED
Conditions: Pelvic Organ Prolapse
Interventions: BEHAVIORAL: Expedited postoperative activity instructions|BEHAVIORAL: Standard postoperative activity restructions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer
Status: COMPLETED
Conditions: Anal Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: cisplatin|DRUG: fluorouracil|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vilazodone for Corticosteroid-Induced Memory Impairment
Status: COMPLETED
Conditions: Memory Impairment
Interventions: DRUG: Vilazodone|DRUG: Placebo|DRUG: Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Melanoma Patients Immunized With Natural DenDritic Cells
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: nDC vaccination|BIOLOGICAL: placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers in Autoimmune Disease of Nervous System
Status: NOT_YET_RECRUITING
Conditions: Autoimmune Diseases of the Nervous System|Neuromyelitis Optica Spectrum Disorder|Multiple Sclerosis|Guillain-Barre Syndrome|Acute Disseminated Encephalomyelitis|Autoimmune Encephalitis|Stiff-Person Syndrome|Myasthenia Gravis|Chronic Inflammatory Demyelinating Polyradiculoneuropathy|Idiopathic Inflammatory Myopathies|Autoimmune Diseases
Interventions: DIAGNOSTIC_TEST: biomaker levels
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination of Cryosurgery and NK Immunotherapy for Tumors in Transplanted Liver
Status: COMPLETED
Conditions: Liver Tumor|Evidence of Liver Transplantation
Interventions: DEVICE: Cryosurgery|BIOLOGICAL: NK immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety of KetoNaph Ophthalmic Solution in Healthy Volunteers
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: KetoNaph|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: TA-8995: Its Use in Patients With Mild Dyslipidaemia (TULIP)
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: TA-8995|DRUG: Atorvastatin|DRUG: Rosuvastatin|DRUG: TA-8995 0mg (placebo)|DRUG: Placebo Statin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Causes and Underlying Factors of Faltering Growth Among Infants
Status: UNKNOWN
Conditions: Infants Aged One Month to 2 Years , Infants With Any Type of Feeding (Breast or Artificial or Weaned Attend Assiut University Children Hospital )
Interventions: DIAGNOSTIC_TEST: complete blood count , electrolytes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Emergency Preservation and Resuscitation (EPR) for Cardiac Arrest From Trauma
Status: RECRUITING
Conditions: Cardiac Arrest From Trauma
Interventions: COMBINATION_PRODUCT: Emergency preservation and resuscitation|OTHER: Standard resuscitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Stigma Among Healthcare Providers (RESHAPE-cRCT)
Status: RECRUITING
Conditions: Mental Disorder|Depressive Disorder|Anxiety Disorder|Alcohol Use Disorder|Psychotic Disorders
Interventions: OTHER: Reducing Stigma among Healthcare Providers (RESHAPE)|OTHER: mental health Gap Action Programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Leukemic Dendritic Cell Vaccination in Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)|Leukemic Dendritic Cell Vaccination
Interventions: BIOLOGICAL: DCP-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: O2 Versus CPAP Treatment Of Patients Undergoing SIPE Therapy (OCTOPUS)
Status: RECRUITING
Conditions: Swimming Induced Pulmonary Edema (SIPE)|Pulmonary Edema|Lung Diseases
Interventions: COMBINATION_PRODUCT: Oxygen + continuous positive airway pressure (CPAP)|DRUG: Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Suvorexant for Opioid/Stimulant Co-use
Status: RECRUITING
Conditions: Opioid Use Disorder|Stimulant Use Disorder
Interventions: DRUG: Suvorexant (dual orexin receptor antagonist)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Lidocaine for Pain Associated With Pancreatic Cancer and Chronic Pancreatitis
Status: COMPLETED
Conditions: Pancreatic Cancer|Chronic Pancreatitis
Interventions: DRUG: Lidocaine IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stress Echo 2030: the Novel ABCDE-(FGLPR) Protocol to Define the Future of Imaging
Status: RECRUITING
Conditions: Coronary Artery Disease|Heart Failure|Hypertrophic Cardiomyopathy|Congenital Heart Disease|Valvular Heart Disease|Post-chest Radio/Chemiotherapy|Heart Transplantation
Interventions: DIAGNOSTIC_TEST: ABCDE-Stress Echo|DIAGNOSTIC_TEST: SE diastolic assessment|DIAGNOSTIC_TEST: SE Right ventricular function assessment|DIAGNOSTIC_TEST: SE in heart donors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Efficacy and Safety of PRC-4016 in Hypertriglyceridemic Subjects
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: PRC-4016|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hulio Interchangeability to Humira®, Comparing Pharmacokinetics, Efficacy, Safety and Immunogenicity
Status: COMPLETED
Conditions: Moderate Chronic Plaque Psoriasis|Severe Chronic Plaque Psoriasis
Interventions: BIOLOGICAL: Humira 40 MG in Prefilled Syringe|BIOLOGICAL: Hulio 40 MG in Prefilled Syringe / Humira 40 MG in Prefilled Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Efficacy of Voice Prosthesis in Voice Reconstruction After Total Laryngectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Laryngectomy; Status
Interventions: DEVICE: Provox Vega Voice prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Observational Study to Investigate the Efficacy, Safety, Tolerability and the Effect on Quality of Life of Telmisartan (Micardis) and Telmisartan With HCTZ (Micardis Plus) in Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: telmisartan/telmisartan + HCTZ (Hydrochlorothiazide)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Point-of-Care Ultrasound in Multidisciplinary Medical Wards
Status: NOT_YET_RECRUITING
Conditions: Point-of-care Ultrasound
Interventions: OTHER: Point-of-Care Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Leucovorin for the Treatment of Language Impairment in Children With Autism Spectrum Disorder
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Folinic Acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fixed Order, Open-Label, Dose-Escalation Study of DMT in Humans
Status: ACTIVE_NOT_RECRUITING
Conditions: Major Depressive Disorder|Depression
Interventions: DRUG: 0.1 mg/kg Dimethyltryptamine (DMT)|DRUG: 0.3 mg/kg Dimethyltryptamine (DMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Determine the Efficacy and Safety of ELS-M11 in Acute Migraine
Status: COMPLETED
Conditions: Migraine Headaches
Interventions: DRUG: ELS-M11|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single and Multiple Ascending Dose Study to Evaluate AMG 786 in Healthy Participants and Participants With Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: AMG 786|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tibet Rhodiola Capsule on Hypoxia and Cardiovascular Risk Factors in Patients With Obstructive Sleep Apnea
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: Tibet Rhodiola Capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tissue Flossing on Recovery Time After Intense Physical Exercise Causing Delayed Onset Muscle Soreness
Status: COMPLETED
Conditions: Health Behavior|Muscle Strain, Lower Leg
Interventions: PROCEDURE: soft tissue flossing therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY900014 in Adult Participants With Type 2 Diabetes Mellitus in India
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin Lispro-aabc|DRUG: Insulin Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Clinical Trial to Evaluate The Efficacy and Safety of Healthtone as Prophylaxis for COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DIETARY_SUPPLEMENT: Rhea® Health Tone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Surgical Optimizing of a Middle Ear Implant (MET )With Laser Velocimetry in Patients With Moderate to Severe Hearing Loss in Case of Failure of Conventional Equipment
Status: COMPLETED
Conditions: Moderate to Severe Hearing Loss|Indication of Middle Ear Implant (MET)
Interventions: DEVICE: Conventional implantation|DEVICE: optimized implantation with laser velocimetry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study Evaluates the Safety, Pharmacokinetics and Efficacy of WX-0593 in Advanced Solid Tumor Patients
Status: UNKNOWN
Conditions: Advanced Solid Tumor, Non-small Cell Lung Cancer
Interventions: DRUG: WX-0593 Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FreeStyle Libre Pro Use in Primary & Secondary Care
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: FreeStyle Libre Pro 4 sensor wears, 2 with reviews|DEVICE: FreeStyle Libre Pro 6 sensor wears, 4 with reviews|DEVICE: FreeStyle Libre Pro 3 sensor wears
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Contractility: Cuff Versus Urodynamics Testing In Males With Voiding Lower Urinary Tract Symptoms
Status: UNKNOWN
Conditions: Lower Urinary Tract Symptoms
Interventions: DIAGNOSTIC_TEST: Penile cuff test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Effectiveness Research of Dual-task and Single-task Balance Training in People With Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: single-task balance training|DEVICE: dual-task balance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Naltrexone HCl/Bupropion HCl Extended Release Versus Placebo for Treatment of Weight Regain in Participants Post Bariatric Surgery
Status: WITHDRAWN
Conditions: Weight Regain Post Bariatric Surgery
Interventions: DRUG: Naltrexone HCl/Bupropion HCl Placebo|DRUG: Naltrexone HCl/Bupropion HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Determine the Effect of Lutropin Alfa on Embryo Quality and Implantation Rate in Advanced Reproductive Age
Status: TERMINATED
Conditions: Infertility|Ovulation Induction
Interventions: DRUG: Recombinant human luteinizing hormone (rhLH)|DRUG: Recombinant follicle-stimulating hormone (rFSH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Letter Encouraging Pneumococcal Vaccination on the 1-year Vaccination Rate in Heart Failure Patients With a Primary Care Physician
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Heart Failure
Interventions: OTHER: Incentive letter for pneumococcal vaccination to the patient and to the GP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION