pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: IMA901 in Advanced Renal Cell Carcinoma Patients With Measurable Disease
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Endoxana, IMA901, Leukine|DRUG: IMA901 and Leukine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of PegIntron and Rebetol in Previously Untreated Patients With Chronic Hepatitis C Infected With HCV Genotype 1/4/5/6 (Study P04243)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: BIOLOGICAL: PegIntron (peginterferon alfa-2b; SCH 54031)|DRUG: Rebetol (ribavirin; SCH 18908)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Placebo Versus Nocebo: Effects on Pain and Anxiety During Local Anaesthetic Infiltration in Parturient Undergoing Elective Caesarean Delivery
Status: COMPLETED
Conditions: Communication
Interventions: BEHAVIORAL: Placebo and Nocebo effect
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Gemcitabine Plus Nab-paclitaxel With or Without FG-3019 in Participants With Locally Advanced, Unresectable Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer (Unresectable)
Interventions: DRUG: FG-3019|DRUG: Gemcitabine|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Hydroxychloroquine to Prevent CIPN
Status: WITHDRAWN
Conditions: Breast Cancer|Gynecologic Cancer|Early-stage Breast Cancer|Peripheral Neuropathy|Chemotherapy-induced Peripheral Neuropathy
Interventions: DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Post-traumatic Stress in ICU Survivors: A Pilot Randomized Controlled Trial of ICU Diaries
Status: COMPLETED
Conditions: Stress Disorders, Post Traumatic|Anxiety|Depression|Quality of Life
Interventions: BEHAVIORAL: ICU Diary|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Two Methods of Bronchial Methacholine Provocation
Status: COMPLETED
Conditions: Bronchial Hyperreactivity|Bronchial Asthma
Interventions: PROCEDURE: Bronchial methacholine provocation|PROCEDURE: Bronchial methacholine provocation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy Study of FemFlow Drug-Eluting Peripheral Balloon Catheter
Status: UNKNOWN
Conditions: Femoral Artery Stenosis|Femoral Artery Occlusion|Popliteal Arterial Stenosis|Popliteal Artery Occlusion
Interventions: DEVICE: FemFlow Drug-Eluting Peripheral Balloon Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MARCH Renal Substudy
Status: COMPLETED
Conditions: Proteinuria|HIV
Interventions: DRUG: arm 1 nucleotide analogue reverse transcriptase inhibitors and boosted protease inhibitors|DRUG: Arm 2 boosted protease inhibitors and maraviroc|DRUG: Arm 3 nucleotide analogue reverse transcriptase inhibitors and maraviroc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Two Mathematical Methods to Estimate Arterial Occlusion Pressure and Tourniquet Effectiveness in Lower Limb Surgery
Status: COMPLETED
Conditions: Vascular Diseases
Interventions: PROCEDURE: Pneumatic tourniquet inflation pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ticagrelor CytoSorb Hemoadsorption
Status: TERMINATED
Conditions: Emergent Cardiothoracic Surgery|Bleeding|Drug Removal
Interventions: DEVICE: CytoSorb 300 mL device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ABT-751 in Treating Young Patients With Refractory Solid Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Childhood Germ Cell Tumor|Extragonadal Germ Cell Tumor|Kidney Cancer|Liver Cancer|Neuroblastoma|Ovarian Cancer|Sarcoma|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: ABT-751
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Data Health VET - Data-driven Health Promotion at Vocational Education and Training Schools
Status: ACTIVE_NOT_RECRUITING
Conditions: Food Habits|Physical Inactivity|Smoking Behaviors|Drug Use|Alcohol Consumption|Wellbeing
Interventions: BEHAVIORAL: Data-driven health promotion at Vocational Education and Training schools (Data Health VET)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Promoting Adherence to Sleep Apnea Treatment Among Blacks With Metabolic Syndrome
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: BEHAVIORAL: Adherence to Sleep Apnea Treatment|OTHER: Standard Care Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Pea Fiber Supplementation on the Gut Microbiota and Host Metabolome and Proteome (FIB)
Status: COMPLETED
Conditions: Microbial Colonization
Interventions: OTHER: Low fiber diet|OTHER: Pea Fiber Bar|OTHER: Low fiber diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Of Oral Sensorimotor Stimulation On Oropharyngeal Dysphagia In Children With Spastic Cerebral Palsy
Status: COMPLETED
Conditions: Physical Therapy
Interventions: OTHER: conventional physical therapy training|OTHER: oral motor training.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Nivolumab Monotherapy and Nivolumab in Combination With Ipilimumab in Pediatric Participants With High Grade Primary Central Nervous System (CNS) Malignancies
Status: COMPLETED
Conditions: Various Advanced Cancer
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM
Status: RECRUITING
Conditions: Hypertrophic Cardiomyopathy
Interventions: GENETIC: TN-201
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of the Pan-immunotherapy in Patients With Unresectable/Metastatic Solid Tumors or Lymphomas
Status: UNKNOWN
Conditions: Solid Tumor|Lymphoma
Interventions: DRUG: Manganese Chloride|DRUG: Anti-PD-1 antibody|COMBINATION_PRODUCT: Systemic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Effects of MEDI-563 in Adults With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: MEDI-563|DRUG: MEDI-563|OTHER: Placebo Comp.|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Myopia Control Combined PBM With Myopic Defocus Lens in Children
Status: RECRUITING
Conditions: Myopia, Progressive
Interventions: DEVICE: PBM|DEVICE: Peripheral defocus spectacles|DEVICE: Single vision spectacles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Suction on Post-Operative Chest Tubes
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DEVICE: Suction is set to -2 cmH2O|DEVICE: Suction is set to -10 cmH2O
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of [123I] AV94 and SPECT in Subjects With Alzheimer Disease in Comparison to Healthy Subjects
Status: TERMINATED
Conditions: Alzheimer Disease
Interventions: DRUG: [123I]AV94
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination Chemotherapy and Donor Stem Cell Transplant Followed by Ixazomib Citrate Maintenance Therapy in Treating Patients With Relapsed High-Risk Multiple Myeloma
Status: COMPLETED
Conditions: Plasma Cell Leukemia|Recurrent Plasma Cell Myeloma
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Carmustine|DRUG: Cytarabine|DRUG: Etoposide|DRUG: Ixazomib Citrate|DRUG: Melphalan|DRUG: Methotrexate|PROCEDURE: Peripheral Blood Stem Cell Transplantation|OTHER: Quality-of-Life Assessment|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pivotal, Open-label, Randomized Study of Radiosurgery With or Without Tumor Treating Fields (TTFields) for 1-10 Brain Metastases From Non-small Cell Lung Cancer (NSCLC).
Status: ACTIVE_NOT_RECRUITING
Conditions: Brain Metastases From Non-small Cell Lung Cancer (NSCLC)
Interventions: DEVICE: NovoTTF-200M device|OTHER: Best Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Everolimus in Patients With Metastatic Colorectal Cancer Who Have Failed Prior Targeted Therapy and Chemotherapy
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Everolimus (RAD001)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propranolol Treatment of Traumatic Memories (PTTM)
Status: UNKNOWN
Conditions: Traumatic Memory|Posttraumatic Stress Disorder
Interventions: DRUG: Propranolol Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inotuzumab Ozogamicin for Children With MRD Positive CD22+ Lymphoblastic Leukemia
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Inotuzumab ozogamicin|DRUG: Methotrexate|DRUG: Hydrocortisone|DRUG: Cytarabine|DRUG: Diphenhydramine|DRUG: Acetaminophen|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Preliminary Administration of Cyclosporine (Sandimmun ®) on Different Markers of Cardiac Ischaemia Induced by Cardiopulmonary Bypass
Status: TERMINATED
Conditions: Coronary Artery Bypass Surgery|Cardiopulmonary Bypass
Interventions: DRUG: Sandimmum|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: STARR Trans-anal Resection Versus Vaginal Rectocele Repair Using Elevate: Effects on Defecatory Function
Status: TERMINATED
Conditions: Rectocele
Interventions: PROCEDURE: STARR rectocele repair|PROCEDURE: Elevate mesh rectocele repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept Study to Evaluate the Efficacy and Safety of BMS-931699 (Lulizumab) or BMS-986142 in Primary Sjögren's Syndrome
Status: TERMINATED
Conditions: Sjögren's Syndrome
Interventions: DRUG: BMS-931699|DRUG: BMS-986142|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Pregnancy Outcomes in Risankizumab Exposed Pregnancies Relative to Those Non-risankizumab Exposed Pregnancies in Women With FDA Approved Indications
Status: RECRUITING
Conditions: Plaque Psoriasis|Psoriatic Arthritis|Crohn Disease|Other Conditions for Which Risankizumab is an FDA-approved Treatment
Interventions: DRUG: Risankizumab|DRUG: Comparator
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Exopulse Mollii Suit Study - a Database for Routine Follow-up of Clinical Outcomes
Status: NOT_YET_RECRUITING
Conditions: Cerebral Palsy|Multiple Sclerosis|Stroke|Spinal Cord Injuries|Neurologic Disorder
Interventions: DEVICE: Exopulse Mollii Suit
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TKA Using Patient-Specific Instrumentation
Status: WITHDRAWN
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Stryker ShapeMatch Technology|DEVICE: Stryker Triathlon Custom Fit Knee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Skin Ulcers Treatment With an Handicraft Topical Device
Status: COMPLETED
Conditions: Foot Ulcer|Varicose Ulcer
Interventions: PROCEDURE: drenovac handcrafted|PROCEDURE: Healing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of the Treatment of Facial Nodular and Nodulocystic Basal Cell Carcinoma With Double Curettage and Cautery Followed by Application of Imiquimod to the Base
Status: UNKNOWN
Conditions: Basal Cell Carcinoma
Interventions: DRUG: Imiquimod cream|PROCEDURE: curettage and cautery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of BRL-201 in the Treatment of r/r B Lymphocyte Non-Hodgkin Lymphoma
Status: RECRUITING
Conditions: Non-hodgkin Lymphoma,B Cell
Interventions: DRUG: CD19-targeted non-viral PD1 site-specific integrated CAR-T cell injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BNP Pharmacodynamics and Effects on Metabolism in Lean and Obese Subjects
Status: COMPLETED
Conditions: Obesity|Cardiovascular Disease|Hypertension|Diabetes
Interventions: DRUG: Nesiritide|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility of Fabric Orthosis for Knee Support in Elderly Gait Improvement
Status: NOT_YET_RECRUITING
Conditions: Gait|Fall|Orthotic Devices
Interventions: DEVICE: Fabric-Type Knee Extensor Muscle-Mimicking Orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase 3 Study to Assess the Efficacy and Safety of PK101 in Patients With Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DRUG: PK101|DRUG: PK101-002|DRUG: PK101 placebo|DRUG: PK101-002 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bispectral Index Monitoring for Sedation in Elective Colonoscopies of Adult Patients: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DEVICE: BIS monitor|DEVICE: Ramsay scale
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Combining MLN8237 With Nab-Paclitaxel in Patients With Advanced Solid Malignancies
Status: COMPLETED
Conditions: Adenocarcinoma|Pancreatic Neoplasms
Interventions: DRUG: MLN8237|DRUG: nab-Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical on the Safety and Efficacy of Fosaprepitant Dimeglumine for Injection in the Prevention of CINV.
Status: RECRUITING
Conditions: Neoplasms
Interventions: DRUG: Fosaprepitant Dimeglumine for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Auriculotherapy for Surgical Pain
Status: COMPLETED
Conditions: Acute Pain|Surgery|Shoulder Pain
Interventions: DEVICE: Auriculotherapy cryopuncture device without nitrogen gas|DEVICE: Auriculotherapy cryopuncture device with nitrogen gas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanism of Fatty Acid-induced Impairment of Glucose-simulated Insulin Secretion - Effect of Buphenyl
Status: COMPLETED
Conditions: Diabetes|Insulin Resistance
Interventions: DRUG: sodium phenylbutyrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Diagnostic and Therapeutic Value of Tissue Ultrafiltration in Patients at Risk of Acute Compartment Syndrome (ACS)
Status: NOT_YET_RECRUITING
Conditions: Acute Compartment Syndrome
Interventions: DEVICE: Tissue Ultrafiltration Catheters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Mass Balance Recovery and Metabolite Profile & Identification of [14C]-APX001 in Healthy Males
Status: COMPLETED
Conditions: Fungal Infection
Interventions: DRUG: [14C]-APX001 Oral Solution|DRUG: [14C]-APX001 Solution for Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sunflower Lecithin Supplementation on Meibomian Gland Function in Adults With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease|Meibomian Gland Dysfunction
Interventions: DIETARY_SUPPLEMENT: Sunflower lecithin|DIETARY_SUPPLEMENT: Olive oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study to Investigate Safety, Tolerability, and Pharmacokinetics of JNJ-63623872 in Healthy Japanese Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-63623872 (300 mg)|DRUG: JNJ-63623872 (600 mg)|DRUG: JNJ-63623872 (1200 mg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Doxycycline to Reduce Sputum MMP-9 Activity in Adult Cystic Fibrosis (CF) Patients
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Doxycycline|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Venetoclax in Combination With Cladribine and Cytarabine Alternating With Azacitidine Plus Venetoclax for the Treatment of Newly Diagnosed Monocytic AML and Active Signaling Mutated AML
Status: NOT_YET_RECRUITING
Conditions: Acute Monocytic Leukemia|Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|DRUG: Cladribine|DRUG: Cytarabine|PROCEDURE: Echocardiography|PROCEDURE: Lumbar Puncture|PROCEDURE: Multigated Acquisition Scan|OTHER: Questionnaire Administration|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Synergistic Effect of Elemene Plus TKIs Compared With TKIs in EGFR-mutated Advanced NSCLC：Prospective Study
Status: RECRUITING
Conditions: Carcinoma|Non-Small-Cell Lung Cancer|Adenocarcinoma
Interventions: DRUG: Elemene plus first or third generation EGFR-TKIs|DRUG: First or third generation EGFR-TKIs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity of Booster Hepatitis B Vaccines in Children After Liver Transplantation
Status: UNKNOWN
Conditions: Liver Transplantation|Hepatitis B
Interventions: BIOLOGICAL: HBV vaccine booster
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pulmonary Vein Isolation Strategy of Very High Power Short Duration in Patients With Paroxysmal Atrial Fibrillation
Status: NOT_YET_RECRUITING
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: QDOT MicroTM catheter|DEVICE: AI-guided ablation only for PVI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraarticular Distal Radius Fractures, X-fix or Volar Fixation
Status: COMPLETED
Conditions: Dorsally Displaced Intraarticular Distal Radius Fractures|Age 50 - 74 for Females or 60-74 for Males|Low Energy Trauma
Interventions: PROCEDURE: External fixation|PROCEDURE: Volar plate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ICP-022 in the Treatment of Recurrent or Refractory Waldenstrom Macroglobulinemia
Status: COMPLETED
Conditions: Waldenstrom's Macroglobulinemia Recurrent|Waldenstrom's Macroglobulinemia Refractory
Interventions: DRUG: ICP-022
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Health Promoters and Pharmacists in Diabetes Team Management
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: BEHAVIORAL: Pharmacist disease/medication management|BEHAVIORAL: Pharmacist-patient encounters|BEHAVIORAL: Pharmacist medication intensification and adherence support|BEHAVIORAL: Pharmacist communication with primary care physicians|BEHAVIORAL: Pharmacist documentation in electronic medical record|BEHAVIORAL: Health promoter-patient encounters in-person or by phone|BEHAVIORAL: Health promoter medication and lifestyle support|BEHAVIORAL: Health promoter communication with pharmacists
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Serum Bupivacaine Concentration Levels After Injection of Liposomal Bupivacaine Into the Knee
Status: COMPLETED
Conditions: Anesthesia, Local
Interventions: DRUG: liposomal bupivacaine/plain bupivacaine peri-articular injection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Optimizing the Impact of the Healthy School Recognized Campus Program on Youth's CVD Risk Factors
Status: RECRUITING
Conditions: Cardiovascular Diseases|Physical Activity|Nutrition
Interventions: BEHAVIORAL: Mentoring Program|BEHAVIORAL: Enhanced Resources|BEHAVIORAL: Enhanced Engagement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Pegasys (Peginterferon Alfa 2a) Alone or in Combination With Tenofovir in Patients With Chronic Hepatitis D.
Status: COMPLETED
Conditions: Hepatitis D, Chronic
Interventions: DRUG: peginterferon alfa-2a [Pegasys]|DRUG: placebo|DRUG: tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Treatment of Varicose Veins by Endovenous Laser (1940 nm vs 1470 nm)
Status: RECRUITING
Conditions: Varicose Veins
Interventions: PROCEDURE: EVLA 1940 nm|PROCEDURE: EVLA 1470 nm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Flunarizine for the Treatment of Schizophrenia: Comparison With Haloperidol
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Flunarizine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Irrigation Procedures to Treat Apical Periodontitis
Status: COMPLETED
Conditions: Apical Periodontitis
Interventions: PROCEDURE: Irrigation protocols that promote release of dECMs|PROCEDURE: Conventional Irrigation protocols
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block for Pediatric Idiopathic Scoliosis Surgery
Status: RECRUITING
Conditions: Scoliosis Idiopathic
Interventions: DRUG: Sham block|DRUG: ESPB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Peripherally Acting µ-opioid Receptor Antagonist on Recurrent Acute Pancreatitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatitis, Acute
Interventions: DRUG: Placebo treatment|DRUG: Naldemedine 0.2 MG Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Dose-Range Finding Study for ALX-0061 Combination Therapy in Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: ALX-0061|OTHER: Placebo|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Psychomotor Recuperation Study After Deep Sedation for Colonoscopy Between Target Controlled and Manual Titration of Propofol
Status: COMPLETED
Conditions: Colonoscopy (Ambulatory Patients)
Interventions: DRUG: Manual titration of propofol|DRUG: Target controlled infusion of propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Preoperative Re-education on Patients With an Anterior Cruciate Ligament Rupture
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Rupture
Interventions: BEHAVIORAL: Preoperative re-education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Modulating Mechanisms in Patients With Chronic Subjective Tinnitus and/or Chronic Pain
Status: COMPLETED
Conditions: Tinnitus|Pain
Interventions: DIAGNOSTIC_TEST: Self-reported signs of central sensitization|DIAGNOSTIC_TEST: Objective signs of central sensitization|DIAGNOSTIC_TEST: Audiological outcome measures (audiometry, tinnitus analysis, uncomfortable loudness) in tinnitus patients with and without pain|DIAGNOSTIC_TEST: Cognitive functioning|DIAGNOSTIC_TEST: Listening effort|DIAGNOSTIC_TEST: Self-reported psychological factors|DIAGNOSTIC_TEST: Self-reported lifestyle factors|DIAGNOSTIC_TEST: Self-reported measure of pain processing|DIAGNOSTIC_TEST: Self-reported quality of life|DIAGNOSTIC_TEST: Self-reported tinnitus severity and impact on daily life|DIAGNOSTIC_TEST: Self-reported hyperacusis|DIAGNOSTIC_TEST: Self-reported tinnitus characteristics|DIAGNOSTIC_TEST: Self reported neck pain related disability
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Healthy ME: Advancing Health Equity in Lymphatic Pain and Lymphedema in Black and Hispanic Women With Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: BEHAVIORAL: The-Optimal-Lymph-Flow (TOLF) Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Unclogging the Pediatric Emergency Room: Impact of Rapid Viral Diagnostics
Status: COMPLETED
Conditions: Respiratory Infection
Interventions: PROCEDURE: Nasopharyngeal washing for viral antigen detection by immunofluorescence initiated early in ED visit.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Fall Risk Assessment in a Population of Charcot-Marie-Tooth Disease Type 1A (CMT 1A) by Timed Up and Go Test
Status: ACTIVE_NOT_RECRUITING
Conditions: Charcot-Marie-Tooth Type 1A Neuropathy
Interventions: DIAGNOSTIC_TEST: Exploratory physiopathology study, including non-invasive functional explorations carried out in patients with Charcot-Marie-Tooth disease type 1A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Medicaid Enhanced Prenatal/Postnatal Services Using a Nurse-Community Health Worker Team
Status: COMPLETED
Conditions: Perinatal Depression|Stress|Prenatal Health Risk Behaviors|Child Development
Interventions: OTHER: Medicaid Maternal and Infant Support Services|OTHER: Nurse-CHW team
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Adding Pelvic Floor Exercises to the Stabilization Exercises in Treating Low Back Pain During Pregnancy
Status: COMPLETED
Conditions: Pregnancy Related
Interventions: OTHER: Stabilization exercise|OTHER: Pelvic floor exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Spinal Manipulation on Vertebrobasilar and Internal Carotis Arteries in Healthy Population
Status: COMPLETED
Conditions: Vertebral Artery Dissection, Traumatic|Neck Pain
Interventions: DIAGNOSTIC_TEST: Doppler Ultrasonography|PROCEDURE: Manual Chiropractic Spinal Manipulation|DEVICE: Instrumental Chiropractic Spinal Manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: An Innovative Tailored Intervention for Improving Children's Postoperative Recovery (WebTIPS)
Status: COMPLETED
Conditions: Anxiety|Pain|Postoperative Behavior
Interventions: OTHER: Web-based Tailored Intervention Preparation for Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients
Status: COMPLETED
Conditions: Pre-eclampsia Aggravated
Interventions: DRUG: placebo|DRUG: Magnesium Sulphate|DRUG: sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prenatal Screening for Imprinting Anomalies Implicated in Beckwith Wiedemann and Silver Russell Syndromes
Status: UNKNOWN
Conditions: Pregnant Women Requiring Amniocentesis
Interventions: GENETIC: Methylation Index
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: AFIX to Improve HPV Vaccination
Status: COMPLETED
Conditions: Papillomavirus Vaccines|Adolescent Health Services
Interventions: OTHER: AFIX in-person consultation|OTHER: AFIX webinar consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate the Safety of BF-200 ALA (Ameluz®) for Photodynamic Therapy (PDT) in the Treatment of Expanded Fields of Actinic Keratosis (AK)
Status: COMPLETED
Conditions: Actinic Keratoses
Interventions: COMBINATION_PRODUCT: BF-200 ALA and red light LED lamp
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DRUG: Dexmedetomidine|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amino-acid PET Versus MRI Guided Re-irradiation in Patients With Recurrent Glioblastoma Multiforme
Status: UNKNOWN
Conditions: Recurrent Glioma (Glioblastoma Multiforme)
Interventions: RADIATION: Radiation Therapy|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Health of Competitive Fitness Athletes
Status: COMPLETED
Conditions: Resting Metabolic Rate|Bone Mineral Density, Low, Susceptibility to|Body Image|Perfectionism|Depression|Eating Disorder|Exercise-Related Amenorrhea|Exercise Addiction|Binge Eating|Dietary Amenorrhea|Dietary Deficiency
Interventions: OTHER: Psychological health|OTHER: Physiological health
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Investigate the Efficacy and Safety of Tislelizumab Combined With Anlotinib as Maintenance Therapy for ES-SCLC
Status: RECRUITING
Conditions: Extensive Stage Small Cell Lung Cancer
Interventions: DRUG: Tislelizumab|DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pevonedistat and Low Dose Cytarabine in Adult Patients With AML and MDS
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|AML|Advanced Myelodysplastic Syndromes|MDS
Interventions: DRUG: Pevonedistat|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Muscle Strength and Range of Motion Training for Post-platelet Rich Plasma Injection in People With Rotator Cuff Partial Tear
Status: RECRUITING
Conditions: Rotator Cuff Tears
Interventions: DEVICE: Modality physical therapy|OTHER: Combined therapy:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Levobetaxolol Hydrochloride Eye Drops for Treatment of Primary Open-angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Primary Open-angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Levobetaxolol eye drops|DRUG: Betaxolol eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Irradiation of the Para-Aortic Lymph Nodes in Locally Advanced Uterine Cervical Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Cancer
Interventions: RADIATION: EFI|RADIATION: Pelvic RT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of Omarigliptin (MK-3102) Compared With Glimepiride in Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin (MK-3102-016)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Omarigliptin|DRUG: Placebo to Omarigliptin|DRUG: Glimepiride|DRUG: Glimepiride Placebo|DRUG: Metformin|DRUG: Insulin Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing Myocardial Blood Flow and Blood Flow Reserve by Transoesophageal Echocardiography (TEE)
Status: WITHDRAWN
Conditions: Coronary Artery Disease
Interventions: DRUG: SonoVue|DRUG: Optison
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Transdermal Iontophoresis of Vitamin B12 Under Three Different Skin Preparations
Status: COMPLETED
Conditions: Macrocytic Anemia With Vitamin B12 Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin B12
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Lean Body Mass in Head and Neck Cancer Patients During Cisplatin-based Chemoradiation
Status: COMPLETED
Conditions: Head and Neck Cancer Patients|Lean Body Mass|Body Composition Changes
Interventions: DIAGNOSTIC_TEST: DXA scan|BEHAVIORAL: Physical testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Fabry Cardiomyopathy: Identification of Early Myocardial Structural and Tissue Abnormalities Using Multiparametric MRI
Status: RECRUITING
Conditions: Fabry Disease
Interventions: DIAGNOSTIC_TEST: Cardiac MRI, ECG/Holter and Blood Biomarkers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study on Regenerative Treatment of Intra-bony Defects
Status: COMPLETED
Conditions: Periodontal Disease|Periodontal Attachment Loss
Interventions: DEVICE: Ostim|DEVICE: Emdogain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Concomitant Chemo-radiotherapy Followed by MIDLE Chemotherapy in Stage I/II Extranodal NK/T-cell Lymphoma
Status: COMPLETED
Conditions: Extranodal NK-T-Cell Lymphoma, Nasal and Nasal-Type
Interventions: RADIATION: CCRT+MIDLE chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intraoperative Magnesium Sulphate on the Occurrence of Postoperative Delirium
Status: RECRUITING
Conditions: Patients Undergoing Lumbar Fixation
Interventions: DRUG: Mg sulphate|DRUG: conventional anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Nicotinamide Riboside Supplementation for Treating Arterial Stiffness and Elevated Systolic Blood Pressure in Patients With Moderate to Severe CKD
Status: RECRUITING
Conditions: Vascular Diseases|Kidney Disease|Blood Pressure|Oxidative Stress
Interventions: DRUG: Nicotinamide riboside
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intermittent Hypoxia and Inspiratory Threshold Loading to Enhance Inspiratory Muscle Function
Status: COMPLETED
Conditions: Intermittent Hypoxia
Interventions: OTHER: Intermittent Hypoxia|OTHER: Inspiratory Threshold Loading|OTHER: Sham Intermittent Hypoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Ketamine In the Treatment of Pediatric Bipolar Disorder
Status: TERMINATED
Conditions: Bipolar Disorder
Interventions: DRUG: Ketamine hydrochloride injection|DRUG: Flat tonic water (e.g., Canada Dry Tonic Water)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Bioequivalence of a Mometasone Nasal Spray, 50 mcg/Actuation Compared With Nasonex® Nasal Spray 50 mcg/Actuation in the Relief of the Symptoms of Seasonal Allergic Rhinitis (SAR)
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Mometasone furoate|DRUG: Nasonex Nasal Spray|DRUG: Placebo nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Diuretic Resistance in Heart Failure, Aim 2
Status: RECRUITING
Conditions: Heart Failure
Interventions: DRUG: Placebo|DRUG: Amiloride|DRUG: Bendroflumethiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: NSAID vs Steroid in Trabeculectomy Wound Management
Status: UNKNOWN
Conditions: Glaucoma
Interventions: DRUG: Bromfenac 0.07% Oph Susp|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Pathophysiology of Orthostatic Hypotension
Status: COMPLETED
Conditions: Autonomic Nervous System Diseases|Orthostatic Hypotension|Dopamine Beta-Hydroxylase Deficiency|Orthostatic Intolerance
Interventions: PROCEDURE: Standing or upright tilt|PROCEDURE: Microneurography|PROCEDURE: QSweat|DEVICE: neck cuff stimulation|DRUG: phenylephrine,isoproterenol,nitroprusside,propranolol,edrophonium,atropine,tyramine|DRUG: clonidine,yohimbine,metoclopramide,alpha-methyldopa|PROCEDURE: BodPod|PROCEDURE: Eye exam|PROCEDURE: Sleep study|PROCEDURE: Pain response testing|PROCEDURE: Metabolic chamber|PROCEDURE: Brain function studies|PROCEDURE: Bicycle Exercise Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effects of Micronized Trans-resveratrol Treatment on Polycystic Ovary Syndrome (PCOS) Patients
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome (PCOS)
Interventions: DIETARY_SUPPLEMENT: Micronized trans-resveratrol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety & Tolerability Study That Compares Restylane to Restylane With Lidocaine While Correcting Wrinkles in the Nasolabial Folds
Status: COMPLETED
Conditions: Nasolabial Folds
Interventions: DEVICE: Restylane and Restylane-L
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailibilty for Pediatric Powder for Suspension (PfOS) Formulation
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Trametinib tablet|DRUG: Trametinib pediatric formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of TACE Combined With Lenvatinib to Prevent Postoperative Recurrence in Patients With MVI Positive HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma|Lenvatinib
Interventions: DRUG: Lenvatinib|PROCEDURE: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pain Following Treatment of Asymptomatic Necrotic Mandibular Molars in Single Visit Using Wave-one Reciprocating Instruments Versus One-Shape Rotary Instruments
Status: UNKNOWN
Conditions: Necrotic Pulp
Interventions: OTHER: One-shape rotationary system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Look at the Characteristics of Synovial Fluid and Cartilage Matrix in Osteoarthritic Knee After Hyaluronic Acid Injection
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: Euflexxa|DEVICE: Magnetic Resonance Imaging (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Quetiapine Fumarate (Seroquel) for the Treatment of Alcohol Dependence.
Status: COMPLETED
Conditions: Alcoholism
Interventions: DRUG: Seroquel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fentanyl Ultra Low Doses Effects on the Nociceptive Threshold
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Fentanyl/Placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Asthma Symptom Management Through Mindfulness Training
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Mindfulness Based Stress Reduction (MBSR)|BEHAVIORAL: Healthy Living Course (HLC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Efficacy of NTI164 in Young People With Autism Spectrum Disorder
Status: NOT_YET_RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DRUG: NTI164
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hippocampal Prophylactic Cranial Irradiation for Small Cell Lung Cancer
Status: COMPLETED
Conditions: Small-cell Lung Cancer|SCLC|Small Cell Lung Cancer Limited Stage
Interventions: RADIATION: Hippocampal-sparing Prophylactic Cranial Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Metastatic Colorectal Cancer.
Status: COMPLETED
Conditions: Colorectal Neoplasms|Colonic Neoplasms|Rectal Neoplasms
Interventions: DRUG: Vatalanib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT