pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: TOTEM: Trial of TAP Block Effective Medications
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: PROCEDURE: Transversus abdominis plane (TAP) block with liposomal bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Bevacizumab (Avastin) in Combination With Rituximab (MabThera) and CHOP (Cyclophosphamide, Hydroxydaunorubicin [Doxorubicin], Oncovin [Vincristine], Prednisone) Chemotherapy in Patients With Diffuse Large B-cell Lymphoma
Status: TERMINATED
Conditions: B-cell Lymphoma
Interventions: DRUG: Bevacizumab|DRUG: Rituximab|DRUG: CHOP|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Pneumonia Comparing Ceftriaxone With Subglottic Aspiration
Status: COMPLETED
Conditions: Pneumonia
Interventions: DRUG: ceftriaxone|DEVICE: Endotracheal tube for aspiration of subglottic secretions.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Osteopathic Manipulative Treatment on Neuromuscular Control of the Head-neck System
Status: COMPLETED
Conditions: Neck Pain
Interventions: PROCEDURE: Osteopathic manipulative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Cannabidiol (CBD) for Symptoms of PTSD in Adults
Status: RECRUITING
Conditions: PTSD
Interventions: DRUG: Cannabidiol (CBD) as Nantheia ATL5|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Memory Perception Assessment in Central/Non-central Nervous System Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma|Glioma|Breast Cancer|Healthy
Interventions: OTHER: QMRP questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lenalidomide, Ixazomib, and Rituximab as Front-Line Therapy for High Risk Indolent B-Cell Lymphoma
Status: TERMINATED
Conditions: B Cell Lymphoma|Lymphoma
Interventions: DRUG: Ixazomib|DRUG: Lenalidomide|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endobronchial Cryotherapy in Management of MEBO in Patients With Inoperable NSCLC
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer|Non-Small Cell Carcinoma of Lung, TNM Stage 4|Bronchogenic Cancer
Interventions: PROCEDURE: cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carboplatin and Paclitaxel in Treating Older Patients With Metastatic or Recurrent Unresectable Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selinexor With ICE Chemotherapy in Secondary Central Nervous System Involving B-cell Non-Hodgkin Lymphoma
Status: RECRUITING
Conditions: B-cell Lymphoma Recurrent|B-cell Lymphoma Refractory|CNS Metastases
Interventions: DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture and Computer-based Training to Improve Attention Deficits in Patients After Stroke
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: RehaCom|DEVICE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Cellular and Humoral Immunity by Vaccinating With PCV13 Before and After CAR-T Therapy
Status: RECRUITING
Conditions: Diffuse Large-Cell Lymphoma|Primary Mediastinal Large B-Cell Lymphoma (PMBCL)|Transformed Follicular Lymphoma (TFL)|High-grade B-cell Lymphoma (HGBCL)|Follicular Lymphoma
Interventions: BIOLOGICAL: Pneumococcal conjugate vaccine (PCV13)|BIOLOGICAL: CD19 targeted CAR T Cell Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Disulfiram and Copper Gluconate With Temozolomide in Unmethylated Glioblastoma Multiforme
Status: TERMINATED
Conditions: Glioblastoma|Glioblastoma Multiforme
Interventions: DRUG: Disulfiram|DIETARY_SUPPLEMENT: Copper gluconate|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial Study to Evaluate the Pharmacokinetic Interaction and Safety Between BR1019-1 and BR1019-2 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Hypertension|Diabetes Mellitus, Type 2
Interventions: DRUG: BR1019-1|DRUG: BR1019-2|DRUG: BR1019-1 + BR1019-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Fillers for Contouring the Jawline
Status: COMPLETED
Conditions: Jawline Contour Deficit
Interventions: DEVICE: Restylane Defyne|DEVICE: Restylane Lyft
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pramipexole on Metabolic Network Activity Compared With Levodopa in Early Parkinson's Disease
Status: COMPLETED
Conditions: Idiopathic Parkinson's Disease
Interventions: DRUG: pramipexole|DRUG: Sinemet CR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zambia Infant Cohort Study - Brains Optimized for Surviving and Thriving
Status: ACTIVE_NOT_RECRUITING
Conditions: Child Development
Interventions: OTHER: ECD intervention for CHEUs|OTHER: Usual care for CHEUs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Brain Protection Effect of Selective Head Cooling and Dexmedetomidine in Patients Undergoing Liver Transplantation
Status: UNKNOWN
Conditions: Liver Transplant; Complications
Interventions: DRUG: Dexmedetomidine|DEVICE: Cooling Helmet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease
Status: RECRUITING
Conditions: Peripheral Artery Disease|Diabetes Mellitus|Chronic Limb-Threatening Ischemia
Interventions: DIAGNOSTIC_TEST: SPECT/CT perfusion imaging|DIAGNOSTIC_TEST: PET/CT perfusion imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of VEGF Tyrosine Kinase Inhibitor (Pazopanib) in Men With High-Risk Prostate Cancer Followed by Radical Prostatectomy and Pelvic Lymph Node Dissection
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate
Interventions: DRUG: Pazopanib|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Effects of Maela Connected Follow-up on Well-being and Pain After Lumbar Spine Surgery
Status: RECRUITING
Conditions: Lumbar Spine Surgery|Quality of Life|Pain
Interventions: OTHER: Maela connected follow-up|OTHER: traditional follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Doxycycline to Treat Chlamydial Infection
Status: RECRUITING
Conditions: Chlamydial Infection
Interventions: DRUG: Doxycycline|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Culturally Adapted Psychoeducation for Bipolar Disorder in a Low-resource Setting: A Randomized Controlled Trial
Status: RECRUITING
Conditions: Bipolar Disorder
Interventions: BEHAVIORAL: Culturally adapted Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prehabilitation to Improve Cancer Surgery Outcomes in AYA Patients With Extremity Sarcomas
Status: COMPLETED
Conditions: Sarcoma,Soft Tissue|Osteosarcoma
Interventions: BEHAVIORAL: Multimodal prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Research Study on How Well Concizumab Works for You if You Have Haemophilia A or B With or Without Inhibitors
Status: RECRUITING
Conditions: Haemophilia A and B With and Without Inhibitors
Interventions: DRUG: Concizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Mobile Phones to Improve Adherence to Inhaled Steroids
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Asthma Supervision|BEHAVIORAL: Mobile Phone|BEHAVIORAL: Inhaled Corticosteroid Mobile Phone Application|BEHAVIORAL: Beta2-adrenergic agonist Mobile Phone Application
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: CARE Mentalizing-Focused Parenting Group Outcomes Study
Status: COMPLETED
Conditions: Parent-Child Relationship|Parenting
Interventions: BEHAVIORAL: CARE Parenting Group Treatment|BEHAVIORAL: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Completely Abdominal Approach Laparoscopic Partial Intersphincteric Resection for Rectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Rectal Cancer
Interventions: PROCEDURE: Lap partial ISR|COMBINATION_PRODUCT: NCRT+Lap partial ISR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bosentan In Exercise Induced Pulmonary Arterial Hypertension in CongenitaL Heart diseasE
Status: UNKNOWN
Conditions: Pulmonary Arterial Hypertension|Congenital Heart Disease
Interventions: DRUG: Bosentan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Embedded Narrative in Interactive Game Design for Improving Medication Adherence of Schizophrenia
Status: ACTIVE_NOT_RECRUITING
Conditions: Schizophrenia and Related Disorders|Medication Adherence|Mental Health Issue|Gamification
Interventions: COMBINATION_PRODUCT: Healing Town: Embedded Narrative in Interactive Game Design
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluate Initial Success Rate of Ultrasound Guided Versus Landmark Approach For Peripheral Intravenous Access
Status: COMPLETED
Conditions: Patients With Peripheral Intravenous Access Lines
Interventions: PROCEDURE: Ultrasound-guided peripheral intravenous access line placement|PROCEDURE: Landmark Approach to peripheral intravenous access line placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resolution of Pain and Swelling After the Use of Neem Leaf Extract Compared to Chlorhexidine Gluconate as an Intracanal Irrigant During Pulpectomy
Status: COMPLETED
Conditions: Periapical Abscess
Interventions: DRUG: Neem leaf extract|DRUG: Chlorhexidine gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Modification Program to Reduce Risk of Coronary Heart Disease in Latina Women With Diabetes
Status: COMPLETED
Conditions: Cardiovascular Diseases|Heart Diseases|Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Mediterranean Diet|BEHAVIORAL: Physical Activity|BEHAVIORAL: Stress Management|BEHAVIORAL: Social Support|BEHAVIORAL: Smoking Cessation|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: High Relaxivity Contrast Agent for Cardiac MR in the Myocardial Scar Assessment
Status: NOT_YET_RECRUITING
Conditions: Myocardial Fibrosis
Interventions: DRUG: Elucirem (Gadopiclenol)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations
Status: NOT_YET_RECRUITING
Conditions: Slow-Flow Vascular Malformation|Fast-Flow Vascular Malformation|Vascular Malformations|Venous Malformation|Lymphatic Malformation, Low Flow|Lymphatic Malformation|Lymphangioma|Arteriovenous Malformations|Venous Malformation, Low Flow|Cystic Hygroma|Vascular Anomaly|Vascular Anomalies|PI3K Gene Mutation|MAP2K1 Gene Mutation|PIK3CA-related Overgrowth Spectrum|Arteriovenous Malformation (AVM)|KRAS G12C|KRAS G12D
Interventions: DRUG: Alpelisib|DRUG: Mirdametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extension Study of Ataluren (PTC124) in Participants With Nonsense Mutation Dystrophinopathy
Status: TERMINATED
Conditions: Muscular Dystrophy, Duchenne|Muscular Dystrophies|Muscular Disorders, Atrophic|Muscular Diseases|Musculoskeletal Diseases|Neuromuscular Diseases|Nervous System Diseases|Genetic Diseases, X-Linked|Genetic Diseases, Inborn
Interventions: DRUG: Ataluren
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety, Tolerability, Pharmacokinetics, and Antiretroviral Activity of Ulonivirine (MK-8507) in Human Immunodeficiency Virus (HIV-1)-Infected Participants (MK-8507-003)
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Ulonivirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid Free vs Opioid Based Anesthesia for Laparoscopic Sleeve Gastrectomy
Status: COMPLETED
Conditions: Obesity|Postoperative Pain|Postoperative Nausea|Postoperative Vomiting|Opioid Use
Interventions: DRUG: Dexmedetomidine Hydrochloride [Dexdor]|DRUG: Remifentanil [Ultiva]|DRUG: Ketamine [Ketalar]|DRUG: Lidocaine [Xylocaine 2%]|DRUG: Magnesium Sulphate [Inj. Magnesii Sulfurici Polpharma]|DRUG: Fentanyl [Fentanyl WZF]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Different Ventilation Strategies on Cerebral Oxygenation Using Near Infrared Spectroscopy (NIRS) in Pediatrics Undergoing Posterior Fossa Tumor Surgery
Status: COMPLETED
Conditions: Infratentorial Neoplasms|Hyperventilation|Craniotomy
Interventions: DEVICE: cerebral oximetry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Tetracaine Combined Spinal Epidural (CSE) Versus Bupivacaine CSE
Status: TERMINATED
Conditions: Labor Pain
Interventions: DRUG: Tetracaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Efficacy of RVL-1201 in the Treatment of Acquired Blepharoptosis
Status: COMPLETED
Conditions: Acquired Blepharoptosis
Interventions: DRUG: RVL-1201|DRUG: RVL-1201 Vehicle Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial of the Efficacy and Safety of a Strategy of Starting With Nelfinavir Versus Ritonavir Added to Background Antiretroviral (AR) Nucleoside Therapy in HIV-Infected Individuals With CD4+ Cell Counts Less Than or Equal to 200/mm3
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Ritonavir|DRUG: Nelfinavir mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Electrical Stimulation (NMES) for Dysphagia in Neonates
Status: TERMINATED
Conditions: Dysphagia
Interventions: DEVICE: VitalStim|DEVICE: Sham VitalStim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improvement Effects of Gamma Aminobutyric Acid（GABA） Supplementation on Treatment of Children With Insomnia
Status: RECRUITING
Conditions: Insomnia
Interventions: DIETARY_SUPPLEMENT: GABA supplement|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sexual Confidence: CBT for Social Anxiety Disorder With HIV Risk Reduction Counselling for HIV-negative gbMSM
Status: RECRUITING
Conditions: Social Anxiety|Sexual Risk|HIV
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy|BEHAVIORAL: Applied Relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Pilot Study on Tailored Eradication Therapy According to Clarithromycin Resistance in H.Pylori Patients
Status: COMPLETED
Conditions: Peptic Ulcer
Interventions: DRUG: Ilaprazole|DRUG: Amoxicillin|DRUG: Clarithromycin|DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer|Diet Habit
Interventions: OTHER: Med|OTHER: WL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetic and Tolerability Study of 14 mg Single Dose of Teriflunomide in Subjects With Severe Renal Impairment
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Teriflunomide HMR1726|DRUG: Cholestyramine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Booster Vaccination in Preventing Disease Recurrence in Previously Vaccinated Patients With Melanoma That Has Been Removed By Surgery
Status: COMPLETED
Conditions: Recurrent Melanoma|Stage IA Skin Melanoma|Stage IB Skin Melanoma|Stage IIA Skin Melanoma|Stage IIB Skin Melanoma|Stage IIC Skin Melanoma|Stage IIIA Skin Melanoma|Stage IIIB Skin Melanoma|Stage IIIC Skin Melanoma|Stage IV Skin Melanoma
Interventions: BIOLOGICAL: gp100:209-217(210M) Peptide Vaccine|BIOLOGICAL: HPV 16 E7:12-20 Peptide Vaccine|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Blood Glucose at the First Trimester of Pregnant Women With Gestational Diabetes on Maternal and Fetal Outcomes and Metabolic Disorders: a Multi-central Prospective Cohort Study
Status: UNKNOWN
Conditions: Gestational Diabetes
Interventions: DIETARY_SUPPLEMENT: Dietary control|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Lenalidomide Plus R-CHOP for CNS Relapse Prophylaxis in Diffuse Large B-cell Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of JNJ-26866138 (Bortezomib) in Untreated Multiple Myeloma Patients Who Are Not Candidates for Hematopoietic Stem Cell Transplant (HSCT)
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: JNJ-26866138 0.7 mg/m2|DRUG: JNJ-26866138 1.0 mg/m2|DRUG: JNJ-26866138 1.3 mg/m2|DRUG: Melphalan|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Extracorporeal Shock Wave Therapy and Low Level Laser Therapy in Myofascial Pain Syndrome
Status: COMPLETED
Conditions: Myofascial Pain Syndrome
Interventions: DEVICE: Extracorporeal Shock Wave Therapy|DEVICE: Low Level Laser Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Interi Manifold in Implant-Based Breast Reconstruction
Status: RECRUITING
Conditions: Mastectomy|Implant Based Breast Reconstruction
Interventions: DEVICE: Interi Manifold Drain System|DEVICE: Jackson Pratt Drain System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pembrolizumab in Patients With Non-Small Cell Lung Cancer and a Performance Status 2
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pregabalin/Tramadol Combination Versus Pregabalin in Acute Pain of Neuropathic Origin
Status: COMPLETED
Conditions: Neuropathic Pain
Interventions: DRUG: Pregabalin 75mg/ Tramadol 50 mg|DRUG: Pregabalin 75mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study to Determine the Effects of Phrenic Nerve Stimulation in Patients With Periodic Breathing
Status: COMPLETED
Conditions: Sleep Disordered Breathing|Cheyne-Stokes Respiration|Sleep Apnea
Interventions: DEVICE: Phrenic stimulation device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Everolimus Versus Mycophenolate Mofetil in Combination With Reduced Dose Cyclosporine Microemulsion in Maintenance Heart Transplant Recipients
Status: COMPLETED
Conditions: Heart Transplantation
Interventions: DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity of a Hantaan Virus DNA Vaccine and a Puumala Virus DNA Vaccine, For The Prevention of Hemorrhagic Fever With Renal Syndrome
Status: UNKNOWN
Conditions: Hantaan Virus Nephropathy|Puumala Virus Nephropathy
Interventions: BIOLOGICAL: Hataan DNA Vaccine/Puumala DNA Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: PK TDF in Thai HIV-infected Children
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: TDF (Tenofovir)|DRUG: Efavirenz|DRUG: lopinavir/ritonavir, atazanavir/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Butorphanol Mitigate Emergence Agitation in Patients Undergoing Functional Endoscopic Sinus Surgery
Status: UNKNOWN
Conditions: Agitation
Interventions: DRUG: Butorphanol|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of XG-104 for the Treatment of Dry Eye
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: XG-104|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Use of Corticosteroid to Prevent Epiretinal Membrane Following Retinal Tear
Status: COMPLETED
Conditions: Epiretinal Membrane
Interventions: DRUG: Prednisolone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hormone Therapy With or Without Definitive Radiotherapy in Metastatic Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: RADIATION: Radiotherapy to the pelvis|DRUG: Hormonal therapy (LHRH agonist and/or antiandrogens)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exosomes Detection for the Prediction of the Efficacy and Adverse Reactions of Anlotinib in Patients With Advanced NSCLC
Status: NOT_YET_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Metformin Use to Improve Pregnancy Outcome in Women With Type 1 Diabetes.
Status: COMPLETED
Conditions: Diabetic Pregnancy|Insulin Resistance|Type1diabetes
Interventions: DRUG: metforminhydrochloride|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Renin and Renal Biomarker Response to Angiotensin II
Status: COMPLETED
Conditions: Septic Shock|Acute Kidney Injury
Interventions: OTHER: Standard of Care|DRUG: Angiotensin II
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Pramipexole for Treatment-Resistant Depression
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Pramipexole (Mirapex)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of AC102 Compared to Steroids in Adults With Idiopathic Sudden Sensorineural Hearing Loss (ISSNHL)
Status: RECRUITING
Conditions: Hearing Loss, Sensorineural
Interventions: DRUG: AC102 gel|DRUG: Prednisolone|OTHER: Placebo Tablets|OTHER: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity of the Inactivated Split-Virion Influenza Vaccine in Renal Transplant Subjects
Status: COMPLETED
Conditions: Influenza|Orthomyxoviridae Infections
Interventions: BIOLOGICAL: Inactivated, split-virion influenza virus|BIOLOGICAL: Inactivated, split-virion influenza virus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Physical Literacy-based Intervention for Older Adults
Status: NOT_YET_RECRUITING
Conditions: Competence|Physical Activity|Knowledge, Attitudes, Practice|Motivation|Confidence, Self|Peer Group
Interventions: BEHAVIORAL: Weekly-based functional fitness training|BEHAVIORAL: Mastering Physical Literacy Class|BEHAVIORAL: Daily based reflective writing|BEHAVIORAL: Buddy Peers Support Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study of Tirzepatide in Chinese Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Tirzepatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate
Status: ACTIVE_NOT_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Placebo for Adalimumab|DRUG: Adalimumab|DRUG: Placebo for Upadacitinib|DRUG: Upadacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Extension Study of 12 mg Proellex® (Telapristone Acetate) Administered Orally in the Treatment of Premenopausal Women With Confirmed Symptomatic Uterine Fibroids
Status: TERMINATED
Conditions: Uterine Fibroids
Interventions: DRUG: Telapristone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Stroke Rehabilitation: Spacing Effect and D-cycloserine
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: D-cycloserine + distributed treatment|BEHAVIORAL: D-cycloserine + condensed treatment|DRUG: Placebo + distributed treatment|BEHAVIORAL: Placebo + condensed treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prostaglandins Before Caserean Section
Status: UNKNOWN
Conditions: Intrapartum Hemorrhage
Interventions: DRUG: Misoprostol 200Mcg Tab|PROCEDURE: elective cesarean section
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: DEDICA (Dose of HEparin During Coronary Angioplasty) Trial
Status: UNKNOWN
Conditions: Stable Angina|Angina, Unstable|Non-ST Elevation (NSTEMI) Myocardial Infarction
Interventions: DRUG: Low-dose heparin|DRUG: Standard dose heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Onset of Action of Mometasone Furoate (MK-0887/SCH 032088) Nasal Spray Compared With Placebo in Seasonal Allergic Rhinitis (C93-184)
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal
Interventions: DRUG: mometasone furoate nasal spray|DRUG: placebo nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sorafenib and Temozolomide in Treating Patients With Stage III or Stage IV Melanoma
Status: UNKNOWN
Conditions: Melanoma (Skin)
Interventions: DRUG: sorafenib tosylate|DRUG: temozolomide|GENETIC: gene expression analysis|GENETIC: mutation analysis|OTHER: laboratory biomarker analysis|OTHER: pharmacological study|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes With Treatment and Withdraw of Secukinumab in Patients With Plaque Psoriasis
Status: NOT_YET_RECRUITING
Conditions: Plaque Psoriasis
Interventions: BIOLOGICAL: secukinumab|DRUG: Methotrexate|DRUG: Cyclosporin A|DRUG: Acitretin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Observational Prospective Study of the Predicted Value of Immature Thrombocytes Counts in Three Different Groups of Critically Ill Patients
Status: UNKNOWN
Conditions: Critically Ill Patients|Neutropenic Fever Patients|Patients With Hip Fractures
Interventions: OTHER: Immature Platelet Fraction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Autonomic Nervous System Modulation on Heart Rate Variability and Musculoskeletal Manifestations in Patients With Chronic Neck Pain
Status: NOT_YET_RECRUITING
Conditions: Autonomic Nervous System Modulation
Interventions: DEVICE: Transcutaneous vagus nerve stimulation|DEVICE: Heart rate variability biofeedback|OTHER: Standard-care physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First-in-Patient Study for Sing le Dose of M201-A Hydrochloride Injection in Japanese Patients With Paroxysmal Atrial Fibrillation
Status: UNKNOWN
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DRUG: M201-A Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Manual Therapy for Tension Headache With Psychological Disorders
Status: COMPLETED
Conditions: Tension-type Headache
Interventions: OTHER: The suboccipital technique|OTHER: The articulatory technique|OTHER: Combined treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Joint Effect of Air Pollution and Exercise on Cognitive Function
Status: UNKNOWN
Conditions: Exercise|Air Pollution|Cognition|Health Promotion
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: Air purification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Resistance Training on Proprotein Subtilisin Convertase Kexin 9 Level After Coronary Bypass Surgery
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: BEHAVIORAL: resistance training|BEHAVIORAL: aerobic training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Weight Loss Maintenance and Compensatory Mechanisms Activated With a Very-low Calorie Diet
Status: COMPLETED
Conditions: Obesity, Morbid
Interventions: BEHAVIORAL: Multidisciplinary outpatient program|BEHAVIORAL: Inpatient lifestyle program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Extension Study to Evaluate the Safety and Tolerability of Licarbazepine in the Treatment of Manic Episodes of Bipolar I Disorder.
Status: COMPLETED
Conditions: Bipolar I Disorder
Interventions: DRUG: Licarbazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rate of Spontaneous Stone Passage as Assessed Using Urinary Ultrasonography and Direct Urinary System Radiography
Status: COMPLETED
Conditions: Ureteral Calculi|Masturbation
Interventions: PROCEDURE: Endoscopic ureterolitotripsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating the Efficacy and Safety of HSK3486 Injectable Emulsion in Subjects Undergoing Fiberoptic Bronchoscopy
Status: COMPLETED
Conditions: Sedation or Anesthesia
Interventions: DRUG: HSK3486|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose Study of PBI-4547 in Healthy Subjects
Status: TERMINATED
Conditions: Healthy Subjects
Interventions: DRUG: PBI-4547|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Postoperative Analgesia
Status: COMPLETED
Conditions: Scoliosis Correction|Postoperative Analgesia|S-ketamine|Dexmedetomidine|Sufentanil
Interventions: DRUG: S-ketamine|DRUG: Dexmedetomidine|DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of ALXN1850 in Treatment-Naïve Pediatric Participants With HPP
Status: RECRUITING
Conditions: Hypophosphatasia
Interventions: DRUG: ALXN1850|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Outcomes With Stapler Versus Hand-Sewn Closure After Minimally Invasive Distal Pancreatectomy
Status: COMPLETED
Conditions: Distal Pancreatectomy|Postoperative Pancreatic Fistula
Interventions: DEVICE: Stapler|OTHER: Suture
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Therapeutic Vaccination for Patients With HPV16+ Cervical Intraepithelial Neoplasia (CIN2/3)
Status: COMPLETED
Conditions: HPV16 Positive|Cervical Intraepithelial Neoplasia (CIN 2/3)
Interventions: BIOLOGICAL: DNA vaccination|DEVICE: Gene gun vaccine|BIOLOGICAL: intramuscular vaccination|BIOLOGICAL: intra-lesional vaccine administration|PROCEDURE: therapeutic resection of the lesion|DRUG: imiquimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS)
Status: RECRUITING
Conditions: Sickle Cell Disease
Interventions: DRUG: Etavopivat Tablets Low dose|DRUG: Etavopivat Tablets High dose|DRUG: Placebo Tablets|DRUG: Etavopivat Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cross-over Study on Effect of Lipid Lowering by Acipimox on Cardiac and Skeletal Muscle Mitochondrial Function
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Cardiomyopathy, Dilated
Interventions: DRUG: Acipimox|DRUG: Cellulosum Mycrocryst
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Acute Effects of Dietary Fiber on Postprandial Responses in Lean and Overweight Subjects
Status: COMPLETED
Conditions: Obesity|Diabetes
Interventions: OTHER: Glucose|OTHER: Inulin|OTHER: Resistant starch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Comparing Hemiarch Replacement and Hemiarch Plus Stent Implantation in Acute Aortic Dissection
Status: RECRUITING
Conditions: Aortic Dissection
Interventions: PROCEDURE: AMDS; Artivion, Atlanta, Georgia, US|PROCEDURE: Conventional hemiarch replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib, Tislelizumab Plus Gemcitabine and Cisplatin (GPLET) in Patients With Advanced Cholangiocarcinoma
Status: RECRUITING
Conditions: Advanced Cholangiocarcinoma
Interventions: DRUG: Lenvatinib, tislelizumab, gemcitabine and cisplatin|DRUG: gemcitabine and cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biweekly Versus Triweekly Raltitrexed With Oxaliplatin (With or Without Bevacizumab) in First-line Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: TOMOX|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention Trial Evaluating Focal Therapy Using High Intensity Focused Ultrasound for the Treatment of Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: PROCEDURE: Focal Therapy Using High Intensity Focused Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Spironolactone in the Prevention of Anthracycline-induced Cardiotoxicity (SPIROTOX)
Status: NOT_YET_RECRUITING
Conditions: Cardiotoxicity|Neoplasms|Chemotherapy Effect|Heart Failure
Interventions: DRUG: Spironolactone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Use of a Remifentanil-propofol Mixture in Patients Undergoing Breast Cancer Surgery
Status: COMPLETED
Conditions: Anesthetics|Remifentanil|Propofol
Interventions: COMBINATION_PRODUCT: Remifentanil-propofol mixture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Improving Hypertension Medication Adherence for Older Adults
Status: RECRUITING
Conditions: Aging|Medication Adherence|Hypertension
Interventions: OTHER: Blood Pressure Technology System M|OTHER: Blood Pressure Technology System E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Tolerability of MA09-hRPE Cells in Patients With Stargardt's Macular Dystrophy(SMD)
Status: COMPLETED
Conditions: Stargardt's Macular Dystrophy
Interventions: BIOLOGICAL: MA09-hRPE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Unicompartmental Versus Total Knee Arthroplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteo Arthritis Knee
Interventions: PROCEDURE: Unicompartmental knee arthroplasty|PROCEDURE: Total knee arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MLN 9708 in Induction and Consolidation for Adults With AML >= 60 Years of Age
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: MLN9708|DRUG: Cytarabine|DRUG: Daunorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reversible Portal Vein Embolization Before Major Hepatectomy
Status: COMPLETED
Conditions: Liver Regeneration|Reversible Portal Vein Embolization
Interventions: PROCEDURE: Selective reversible portal vein embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kinetics of Circulating Tumoral Cells in Bronchial Primitive Cancer
Status: COMPLETED
Conditions: Bronchial Cancer
Interventions: DIAGNOSTIC_TEST: ISET® - Isolation by Size of Tumor cells|DIAGNOSTIC_TEST: ISET® - Isolation by Size of Tumor cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CRISOL Mente: A Multilevel Community Intervention to Reduce Mental Health Disparities Among Latinos
Status: RECRUITING
Conditions: Depression, Unipolar|Anxiety Disorders|Post Traumatic Stress Disorder
Interventions: OTHER: Outreach/navigator|OTHER: Auxiliary to care|OTHER: Stepped care and task shifting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Simvastatin Plus Rifaximin in Decompensated Cirrhosis
Status: COMPLETED
Conditions: Cirrhoses, Liver
Interventions: DRUG: Simvastatin 20 mg|DRUG: Simvastatin 40mg|DRUG: Rifaximin 400 mg|OTHER: Placebo of Simvastatin|OTHER: Placebo of Rifaximin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ponatinib Plus Reduced-intensity Chemotherapy in the First-line Treatment of Adult Patients With Ph+ ALL
Status: TERMINATED
Conditions: Acute Lymphoblastic Leukemia, Adult|Ph+ ALL|Newly Diagnosed
Interventions: DRUG: Ponatinib 15 MG Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of GSK Biologicals' Investigational Malaria Vaccine in HIV Infected Infants and Children
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: GSK Biological's Investigational Malaria Vaccine 257049|BIOLOGICAL: Human Diploid Cell Vaccine (HDCV) or Purified Vero Cell Rabies Vaccine (PVRV, Verorab) (Aventis Pasteur);|BIOLOGICAL: Purified Chick Embryo Cell Culture (PCEC) Rabies Vaccine (Rabipur or equivalent) (Novartis).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optimal Pharmacological Therapy In Implantable Defibrillator Patients (OPTIC)
Status: COMPLETED
Conditions: Ventricular Tachycardia
Interventions: DRUG: amiodarone beta blocker sotalol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Adipose-derived MSCs After Enzymatic Digestion vs. Mechanically Fragmented Fat Transfer in Knee Osteoarthritis Treatment
Status: UNKNOWN
Conditions: Knee Osteoarthritis|Chondropathy
Interventions: PROCEDURE: Autologous adipose derived Mesenchymal Stromal Cells (MSC) injection into the knee joint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT