pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Application and Evaluation of Group Cognitive Intervention for Depressed Adolescents
Status: COMPLETED
Conditions: Community Adolescents at Risk for Depression and Suicide
Interventions: BEHAVIORAL: CBT plus parent education|BEHAVIORAL: CBT alone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Effects of Muscle Flossing on Quadriceps Muscle Potentiation
Status: COMPLETED
Conditions: Ischemia|Placebo - Control
Interventions: OTHER: Flossing experimental group|OTHER: Low wrapping pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study in Healthy Subjects to Investigate Pharmacokinetics of AZD8683 When Administered in Different Ways
Status: WITHDRAWN
Conditions: Healthy
Interventions: DRUG: AZD8683|DRUG: AZD8683|DRUG: AZD8683|DRUG: AZD8683
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety Study of Oral CEM-101 Compared to Oral Levofloxacin in Treatment of Patients With Community-Acquired Bacterial Pneumonia
Status: COMPLETED
Conditions: Community-Acquired Bacterial Pneumonia
Interventions: DRUG: Levofloxacin|DRUG: CEM-101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vasopressin Versus Norepinephrine for the Management of Septic Shock in Cancer Patients
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: Vasopressin|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Caplyta in Borderline Personality Disorder
Status: RECRUITING
Conditions: Borderline Personality Disorder
Interventions: DRUG: Caplyta|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Wear Behavior of Human Enamel and Chipping of Veneered Zirconia Against Monolithic Zirconia
Status: UNKNOWN
Conditions: Broken Tooth With Complication|Non Vital Teeth|Mutilated Teeth
Interventions: OTHER: Veneered zirconia|OTHER: Monolithic zirconia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: L-PRF vs PBM on Extraction Socket Healing
Status: COMPLETED
Conditions: Healing Surgical Wounds|Pain
Interventions: DEVICE: photobiomodulation|OTHER: Leukocyte and Platelet Rich Fibrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Median Effective Dose (ED50) of Paracetamol and Morphine : A Study of Interaction Study
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Paracetamol|DRUG: Morphine|DRUG: Paracetamol- Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pegloticase and Methotrexate Co-administered in Participants With Uncontrolled Gout Who Previously Failed Pegloticase Monotherapy
Status: COMPLETED
Conditions: Uncontrolled Gout
Interventions: BIOLOGICAL: Pegloticase|DRUG: Methotrexate (MTX)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Vinflunine Chemotherapy in Locally-advanced and Metastatic Carcinoma of the Penis (VinCaP)
Status: COMPLETED
Conditions: Locally-advanced or Metastatic Penile Neoplasms
Interventions: DRUG: Vinflunine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mouth Dryness and Thirst of Patients Undergone Major Abdominal Surgery
Status: UNKNOWN
Conditions: Xerostomia|Thirst
Interventions: OTHER: cold water spray application|OTHER: cold saline spray application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Alpha Lipoic Acid on Obesity Related Comorbidities
Status: COMPLETED
Conditions: Obesity|Cardiovascular Disease|Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Alpha Lipoic Acid|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Multiple Dose Study Of PD-0360324 In Patients With Active Cutaneous Lupus Erythematosus
Status: TERMINATED
Conditions: Cutaneous Lupus Erythematosus
Interventions: DRUG: PD-0360324|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mortality, Morbidity and Risk Factors of Liver Retransplantation
Status: COMPLETED
Conditions: Liver Transplant; Complications|Liver Transplant Rejection|Liver Transplant Failure|Liver Diseases|Liver Cirrhosis|Liver Failure|Organ Transplant Failure or Rejection
Interventions: OTHER: Liver Transplantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Streptococcus Mutans Reduction Early Mother-infant Transmission
Status: COMPLETED
Conditions: Pregnant Women
Interventions: DRUG: Pregnant women to whom applied silane fluoride|DRUG: Pregnant women to whom applied silane fluoride + 1% chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Abemaciclib and Niraparib Before Surgery for the Treatment of Hormone Receptor Positive HER2 Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|HER2 Negative Breast Adenocarcinoma|Hormone Receptor Positive Breast Adenocarcinoma|Invasive Breast Carcinoma|Multifocal Breast Carcinoma|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Unilateral Breast Carcinoma
Interventions: DRUG: Abemaciclib|DRUG: Niraparib Tosylate Monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Effectiveness of Methylphenidate in Swedish Male Prison Inmates With Attention-deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: PR OROS Methylphenidate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PRIME: Panitumumab Randomized Trial In Combination With Chemotherapy for Metastatic Colorectal Cancer to Determine Efficacy
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Panitumumab|DRUG: FOLFOX regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Approaches To The Maxillary Sinus: A Comparative Study
Status: UNKNOWN
Conditions: Maxillary Sinus Surgery
Interventions: PROCEDURE: Endoscopic Approaches To Maxillary Sinus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab and Imatinib Mesylate in Treating Patients With Recurrent or Metastatic HER2/Neu-Expressing Cancer
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: trastuzumab|DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Dual Algorithm Post Market Clinical Study
Status: COMPLETED
Conditions: HTLV-I Infections|HTLV-II Infections|Human T-lymphotropic Virus 1|Human T-lymphotropic Virus 2|HTLV I Associated T Cell Leukemia Lymphoma|HTLV I Associated Myelopathies
Interventions: DIAGNOSTIC_TEST: MP Diagnostics HTLV Blot 2.4
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect and Safety of Huaier Granules Combined With Targeted Drugs and Anti-PD-(L)1 Antibody Compared With Targeted Drugs Combined With Anti-PD-(L)1 Antibody in First Line Treatment of Unresectable Hepatocellular Carcinoma(uHCC)
Status: NOT_YET_RECRUITING
Conditions: Unresectable Hepatocellular Carcinoma
Interventions: DRUG: Huaier granule|DRUG: Atezolizumab + Bevacizumab|DRUG: Camrelizumab+Apatinib|DRUG: Sintilimab+Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Early Nasojejunal Tube to Meet Energy Requirements in Intensive Care (ENTERIC) Study
Status: UNKNOWN
Conditions: Critical Illness|Malabsorption Syndromes
Interventions: PROCEDURE: Early jejunal feeding (using frictional NJ tube)|PROCEDURE: Standard feeding (using nasogastric [NG] tube)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Tacrolimus Combined With Entecavir on HBV Associated Glomerulonephritis(HBV-GN)
Status: UNKNOWN
Conditions: Hepatitis B Virus Associated Nephrotic Syndrome
Interventions: DRUG: Tacrolimus &entecavir|DRUG: placebo & entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Post-prandial Glucose Response From Phytochemical Rich Potato Products
Status: COMPLETED
Conditions: Glycemic Response|Appetitive Behavior
Interventions: OTHER: Skin Off French Fry|OTHER: Skin On French Fry|OTHER: Hash brown|OTHER: Carbohydrate control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Internet-Based Exercise and Diet Support in Prostate Cancer Survivors
Status: COMPLETED
Conditions: Cancer Survivor|Prostate Carcinoma
Interventions: BEHAVIORAL: Written Information|BEHAVIORAL: Prescription|BEHAVIORAL: Technology|BEHAVIORAL: Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Neuromodulation and Cognitive Training for Suicide in Veterans (ENACTS)
Status: RECRUITING
Conditions: Suicide|Impulsivity
Interventions: DEVICE: Active Transcranial Direct Current Stimulation (tDCS)|DEVICE: Sham Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics (PK) Study of Oxytocin (GR121619) Administered Via an Inhaled Route in Healthy Female Volunteers
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: IM oxytocin 10 IU|DRUG: IH oxytocin 50 mcg|DRUG: IH oxytocin 200 mcg|DRUG: IH oxytocin 400 mcg|DRUG: IH oxytocin 600 mcg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of JWCAR029 in Subjects With R/R CLL/SLL
Status: WITHDRAWN
Conditions: Leukemia, Lymphocytic, Chronic, B-Cell
Interventions: GENETIC: JWCAR029 (Relmacabtagene Autoleucel)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility, Tolerance and Efficacy of Interferon-free, Antiviral Treatment With Sofosbuvir + Ribavirin for the Treatment of Genotype 2 and Sofosbuvir/Ledipasvir for the Treatment of Genotype 1 and 4 Hepatitis C Virus-infected Patients in West and Central Africa
Status: COMPLETED
Conditions: Hepatitis C|HIV Infection
Interventions: DRUG: Sofosbuvir|DRUG: Ribavirin|DRUG: Sofosbuvir|DRUG: Ledipasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk of Methicillin-resistant S.Aureus (MRSA) Infections in MRSA Carrier Under Introduction of Rapid MRSA Screening
Status: COMPLETED
Conditions: Inflammatory Bowel Disease|Hepatobiliary Disease|Pancreas Disease
Interventions: DRUG: vancomycin, mupirocin ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparative, Multicenter Study in Subjects With Rheumatoid Arthritis, ALVOFLEX
Status: ACTIVE_NOT_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: AVT05 (proposed biosimilar to golimumab)|BIOLOGICAL: Simponi (Golimumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effect of Neglected Tropical Diseases on Plasmodium Falciparum Transmission in an Area of Co-endemicity
Status: COMPLETED
Conditions: Malaria Transmission
Interventions: OTHER: Pre-treatment follow up|OTHER: S. haematobium treatment|OTHER: Post treatment follow up|OTHER: Olfactometer experiment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Docosahexaenoic Acid (DHA) on Children With Nonalcoholic Fatty Liver Disease (NAFLD)
Status: COMPLETED
Conditions: Fatty Liver|Liver Fibrosis|Obesity|Metabolic Syndrome|Nonalcoholic Fatty Liver Disease
Interventions: DRUG: DHA250|DRUG: DHA500|DRUG: PLACEBO|BEHAVIORAL: Lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does Heart Rate Variance (HRV) Biofeedback Help Regulate Emotions and Improve Mindfulness in Mentally Unwell Offenders?
Status: UNKNOWN
Conditions: Emotional Dysfunction
Interventions: OTHER: Difficulties in Emotional Regulation Scale, Five Facet Mindfulness Questionnaire, Becks Depression and Becks Anxiety|BEHAVIORAL: HRV Biofeedback (Healing Rhythms)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastric Per Oral Endoscopic Myotomy (G-POEM) in Refractory Gastroparesis
Status: COMPLETED
Conditions: Gastroparesis Postoperative|Gastroparesis Due to Diabetes Mellitus|Idiopathic Gastric Stasis
Interventions: PROCEDURE: G-POEM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Escalated Application of Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis Patients
Status: COMPLETED
Conditions: Motor Neuron Disease
Interventions: BIOLOGICAL: Autologous Mesenchymal stem cells (MSCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Oxygen Administration on Regional Cerebral Oxygen Saturation (rSO2) in the Non-block Side After Stellate Ganglion Block
Status: COMPLETED
Conditions: SSNHL(Sudden Sensory Neural Hearing Loss)
Interventions: PROCEDURE: oxygen administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate Reactogenicity and Immunogenicity of Revaccination With Adjuvanted Influenza Vaccine in Elderly
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluarix and adjuvanted influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study to Investigate the Efficacy of Intratumoral Tigilanol Tiglate in Soft Tissue Sarcoma
Status: RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: Tigilanol Tiglate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Faecal Microbiota Transplantation From Normal Pouch Function Donor in the Treatment of Chronic Pouchitis
Status: COMPLETED
Conditions: Pouchitis|Inflammatory Bowel Diseases|Ulcerative Colitis
Interventions: OTHER: Faecal microbiota transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Rocuronium 0.3 mg/kg, and 0.9 mg/kg for Induction of Anesthesia in Elderly Patients.
Status: COMPLETED
Conditions: Neuromuscular Blockade|Neuromuscular Blockade, Residual|Anesthesia|Intubation Complication
Interventions: DRUG: Rocuronium 0,3mg/kg|DRUG: Rocuronium 0,9mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intradermal COVID-19 Vaccination in the Immunocompromised
Status: RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: ID BNT162b2 vaccine|BIOLOGICAL: IM BNT162b2 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics, Safety and Tolerability Study of AVT02 to EU-approved and US-licensed Humira (Adalimumab)
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Measuring Opioid Use After Rotator Cuff Repair: Comparing the Effects of Standard vs. Extended-release Nerve Blocks
Status: COMPLETED
Conditions: Rotator Cuff Tears
Interventions: DRUG: Liposomal bupivacaine|DRUG: Bupivacaine Hcl 0.25% Inj
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Methylprednisolone in COVID-19 Patients (Methyl19LGH)
Status: UNKNOWN
Conditions: SARS-CoV Infection|SARS (Severe Acute Respiratory Syndrome)
Interventions: DRUG: Methylprednisolone Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel, Cisplatin, and Fluorouracil Followed By Cetuximab and Radiation Therapy in Treating Patients With Locally Advanced Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: cisplatin|DRUG: docetaxel|DRUG: fluorouracil|PROCEDURE: computed tomography|PROCEDURE: positron emission tomography|PROCEDURE: quality-of-life assessment|RADIATION: 3-dimensional conformal radiation therapy|RADIATION: intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation on 15-Prostaglandin Dehydrogenase Expression in Barrett's Esophagus
Status: COMPLETED
Conditions: Short Segment Barrett's Esophagus|Long Segment Barrett's Esophagus
Interventions: DRUG: Omeprazole|DRUG: Vitamin D3|DRUG: Vitamin D3|PROCEDURE: upper endoscopy|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Effect of Multiple Doses of BIRT 2584 XX Tablets on the Pharmacokinetic Parameters of Warfarin, Omeprazole, Caffeine, and Dextromethorphan in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIRT 2584 XX|DRUG: Warfarin sodium|DRUG: Omeprazole|DRUG: Dextromethorphan hydrobromide|DRUG: Caffeine|DRUG: Midazolam hydrochloride|DRUG: Vitamin K1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decision Aid Feasibility Trial for Families of Critically Ill Stroke Patients
Status: WITHDRAWN
Conditions: Ischemic Stroke|Ischaemic Stroke With Coma|Intracerebral Hemorrhage|Hemorrhagic Stroke
Interventions: OTHER: Decision Aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: RCT: The Effect of an Electronic Clinical Decision Support Application on Perioperative Medication Errors.
Status: UNKNOWN
Conditions: Perioperative Medication Errors|Perioperative Adverse Medication Events
Interventions: OTHER: Electronic Clinical Decision Support Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ketamine Efficacy for Acute Severe Bronchospasm in ICU: MACANUDO Trial
Status: COMPLETED
Conditions: Critical Illness|Asthma|Bronchospasm
Interventions: DRUG: Ketamine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Generation of SARS-CoV-2-specific T Lymphocytes From Recovered Donors and Administration to High-risk COVID-19 Patients
Status: RECRUITING
Conditions: Severe COVID-19
Interventions: BIOLOGICAL: Coronavirus-2-specific T cells|OTHER: standard of care (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yearly Licence Tolerability and Immunogenicity Study of Fluval AB Seasonal Influenza Vaccine to be Used in the 2012/2013 Vaccination Season
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: Fluval AB vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nintedanib Plus EGFR TKI In EGFR-mutated Non-small Cell Lung Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer|EGFR Gene Mutation|EGFR-TKI Resistant Mutation
Interventions: DRUG: Nintedanib, gefitinib, erlotinib, afatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Umblical Artery Systolic \Diastolic Ratio and Amniotic Fluid Index in Prediction of Fetal Outcome in Term Pregnancy
Status: NOT_YET_RECRUITING
Conditions: Umblical Artery Doppler in Term Pregnancy
Interventions: RADIATION: ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: HA35 Treatment the Gingival Discomfort as Well as Gingival Redness and Bleeding of Patients With Periodontitis
Status: COMPLETED
Conditions: Periodontitis
Interventions: DRUG: HA35(L20200708MP07707, Ministry of Health, Mongolia) was freshly manufactured by mixing hyaluronidase PH20 injectable solution (H31022111) and high-molecular-weight HA injectable solution (H20174089)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of GT103 in Combination With Pembrolizumab in Refractory, Metastatic Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer|Metastatic NSCLC|Recurrent Non Small Cell Lung Cancer
Interventions: DRUG: Pembrolizumab|DRUG: GT103
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid During Cystectomy Trial (TACT)
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: Tranexamic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Erector Spinae Plane Block Versus TAP Block for Postoperative Analgesia of Laparoscopic Appendectomy
Status: RECRUITING
Conditions: Laparoscopic Appendectomy
Interventions: PROCEDURE: erector spinae plane block (ESP)|PROCEDURE: transversus abdominis plane block(TAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Dose Dexamethasone for Distal Radius Fractures
Status: UNKNOWN
Conditions: Post Operative Pain|Distal Radius Fracture
Interventions: DRUG: Dexamethasone 4mg|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CV Wizard: Does a Clinical Decision Support Tool Improve CVD Risk Factor Control in Safety Net Clinics?
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Attack|Stroke|Cardiovascular Diseases
Interventions: BEHAVIORAL: CV WIZARD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Tiotropium 2.5 and 5 mcg Once Daily Delivered Via the Respimat® Inhaler Compared to Placebo in 1 to 5 Year Old Patients With Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: tiotropium-bromide|DRUG: tiotropium-bromide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety, Antiviral Effect and PK of BI 207127 + BI 201335 +/- RBV for 4 up to 40 Weeks in Patients With Chronic HCV Genotype 1 Infection
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: BI 207127|DRUG: BI 201335|DRUG: BI 207127|DRUG: BI 201335|DRUG: Ribavirin|DRUG: Ribavirin|DRUG: Ribavirin|DRUG: BI 207127|DRUG: BI 207127|DRUG: BI 207127|DRUG: BI 201335|DRUG: Ribavirin|DRUG: Ribavirin|DRUG: BI 207127|DRUG: BI 207127|DRUG: BI 201335|DRUG: BI 201335|DRUG: Ribavirin|DRUG: BI 201335|DRUG: BI 201335|DRUG: BI 207127|DRUG: BI 201335|DRUG: BI 201335|DRUG: BI 207127|DRUG: BI 201335|DRUG: Ribavirin|DRUG: Ribavirin|DRUG: BI 207217|DRUG: BI 201335|DRUG: BI 207127|DRUG: Ribavirin|DRUG: BI 207127|DRUG: BI 201335|DRUG: Ribavirin|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Effectiveness and Tolerability of MK8141 in Patients With High Blood Pressure (MK-8141-006)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: MK8141|DRUG: Comparator: placebo (unspecified)|DRUG: Enalapril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Tolerability Study of CP-690,550 in Subjects With Hepatic Impairment and Normal Hepatic Function
Status: COMPLETED
Conditions: Hepatic Insufficiency
Interventions: DRUG: CP-690,550|DRUG: CP-690,550|DRUG: CP-690,550
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Auricular Percutaneous Electrical Nerve Field Stimulation for Postoperative Pain Control in Adults
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DEVICE: Percutaneous auricular neurostimulation|DEVICE: Sham percutaneous auricular neurostimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Safety, Tolerability, and Pharmacokinetic (PK) Profile of EGT0001474 in Healthy Volunteers
Status: COMPLETED
Conditions: Safety and Tolerability of EGT0001474 in Healthy Volunteers
Interventions: DRUG: EGT0001474|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Bevacizumab to Treat Women With a History of Breast Cancer and Suffering From Upper Extremity Lymphedema
Status: UNKNOWN
Conditions: Lymphedema
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immersive Virtual REality for Treatment of Unilateral Spatial NEglect Via Eye-tracking Biofeedback
Status: RECRUITING
Conditions: Neglect, Hemispatial|Stroke
Interventions: DEVICE: Immersive Virtual Reality|DEVICE: Sham Immersive Virtual Reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GE-148-002: A Phase 2, Open-label, Single-Center Study to Assess GE-148 (18F) Injection PET Imaging to Detect Localized Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: GE-148 (18F)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Weight-based Dosing for Dense Weekly Paclitaxel and Carboplatin in Overweight Patients w/ Body Surface Area (BSA) > 2.0
Status: TERMINATED
Conditions: Gynecologic Malignancies
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Derazantinib and Atezolizumab in Patients With Urothelial Cancer
Status: COMPLETED
Conditions: Urothelial Carcinoma
Interventions: DRUG: Derazantinib 300 mg once daily monotherapy|DRUG: Derazantinib 200 mg once daily + atezolizumab 1200 mg|DRUG: Derazantinib 300 mg once daily+ atezolizumab 1200 mg|DRUG: Derazantinib 200 mg twice daily + atezolizumab 1200 mg|DRUG: Derazantinib 300 mg once daily monotherapy (QD)|DRUG: Derazantinib 300 mg once daily + atezolizumab 1200 mg|DRUG: Derazantinib 200 mg twice daily monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of Diuretics for Symptomatic Malignant Ascites Episodes in Advanced Stage of Cancer (DIASC)
Status: TERMINATED
Conditions: Cancer
Interventions: DRUG: Spironolactone (+/- Furosemide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous Infliximab After A Previous Intravenous Dose Optimization
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases|Crohn Disease|Ulcerative Colitis
Interventions: DRUG: Infliximab|DRUG: Infliximab|DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Potential for Drug Interaction Between SCH 58235 (Ezetimibe) and Pitavastatin (Study P03962)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: SCH 58235|DRUG: pitavastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bronchoscopy and Electric Impedance Tomography (EIT) Pilot Study
Status: UNKNOWN
Conditions: Electric Impedance Tomography|Bronchoscopy|Change in Lung Impedance Due to Ventilation|Recruitment|Improvement the Treatment of the Patient
Interventions: DEVICE: Electrical Impedance Tomography (EIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cinacalcet stUdy for Peritoneal Dialysis Patients In Double Arm on the Lowing Effect OF iPTH Level
Status: COMPLETED
Conditions: Secondary Hyperparathyroidism
Interventions: DRUG: cinacalcet|DRUG: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Haploidentical Stem Cell Transplant for Treatment Refractory Hematological Malignancies
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia (ALL)|Acute Myeloid Leukemia (AML)|Secondary AML|Myelodysplastic Syndrome (MDS)|Secondary MDS|Chronic Myeloid Leukemia|Juvenile Myelomonocytic Leukemia (JMML)|Paroxysmal Nocturnal Hemoglobinuria (PNH)|Lymphoma, Non-Hodgkin|Hodgkin Disease
Interventions: PROCEDURE: Stem Cell Transplantation|DEVICE: Miltenyi Biotec CliniMACS|DRUG: Systemic chemotherapy and antibodies
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Exercise on Neurocognitive Function Among Adults With/Without Generic Risk of AD
Status: COMPLETED
Conditions: Alzheimer Disease 2 Due to Apoe4 Isoform
Interventions: BEHAVIORAL: LI-40|BEHAVIORAL: MI-30|BEHAVIORAL: HI-16
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Relation Between MiR-125b-5p and Staging of Endometriosis
Status: COMPLETED
Conditions: Endometriosis
Interventions: PROCEDURE: laparoscopic examination|DIAGNOSTIC_TEST: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Esomeprazole Versus Pantoprazole to Prevent Peptic Ulcer Rebleeding
Status: WITHDRAWN
Conditions: Peptic Ulcer
Interventions: DRUG: Esomeprazole|DRUG: Pantoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: THC Effects on Glucose in Type 2 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: THC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Unilateral Cleft Lip Closure - Development of a New Hybrid Technique
Status: UNKNOWN
Conditions: Complete Unilateral Cleft Lip
Interventions: PROCEDURE: Unilateral Cleft Lip Repair: Hybrid Technique|PROCEDURE: Unilateral Cleft Lip Repair: Millard 2 Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Breathing Exercises and Meditation on Improving Quality of Life in Glaucoma Patients
Status: NOT_YET_RECRUITING
Conditions: Glaucoma|Depression|Anxiety|Quality of Life|Sleep Disorder
Interventions: BEHAVIORAL: Breathing Exercises followed by Meditation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Trial to Evaluate the Immunogenicity and Safety of an Adjuvanted A(H1N1)v Influenza Vaccine and a Non-adjuvanted A(H1N1)v Influenza Vaccine in HIV-infected Patients (ANRS 151 Hifluvac)
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: adjuvanted A(H1N1)v influenza vaccine|BIOLOGICAL: non-adjuvanted A(H1N1)v influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of Pharmacokinetics (PK) and Pharmacodynamics (PD) in Relation to Prednisolone in Healthy Males
Status: COMPLETED
Conditions: Immunoscience
Interventions: DRUG: Prednisolone|DRUG: BMS-791826|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Utilizing the Crosstalk Among Chicoric Acid, 13-Cis Retinoic Acid(Aerosolized), Minocycline and Vitamin D as a Potent Quadrate Therapy for Treating Patients With Multidrug-resistant TB and Patient With Both Multidrug-resistant TB and COVID-19
Status: UNKNOWN
Conditions: Tuberculosis
Interventions: COMBINATION_PRODUCT: 13 cis retinoic acid, Minocycline, Chicroic Acid and Vitamin D for (MDR-TB)|COMBINATION_PRODUCT: 9 cis retinoic acid, Minocycline, Chicroic Acid and Vitamin D for (MDR-TB)|COMBINATION_PRODUCT: All trans retinoic acid , Minocycline,Chicroic Acid and Vitamin D for (MDR-TB)|COMBINATION_PRODUCT: All trans retinoic acid, Minocycline, Chicroic Acid and Vitamin D For (COVID-19 and MDR-TB)|COMBINATION_PRODUCT: 13 cis retinoic acid, Minocycline, Chicroic Acid and Vitamin D For (COVID-19 and MDR-TB)|OTHER: The standard therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase Ia Study of ChAd63/MVA PvDBP
Status: COMPLETED
Conditions: Malaria|Plasmodium Vivax
Interventions: BIOLOGICAL: ChAd63 PvDBP 5 x 10^9|BIOLOGICAL: ChAd63 PvDBP 5 x 10^10|BIOLOGICAL: MVA PvDBP 1 x 10^8|BIOLOGICAL: MVA PvDBP 2 x 10^8
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy,Safety and Tolerability of Dihydroartemisinin-Piperaquine for Uncomplicated Malaria in Pregnancy in Ghana
Status: COMPLETED
Conditions: Pregnancy Complicated by Malaria as Antepartum Condition
Interventions: DRUG: artesunate-amodiaquine|DRUG: Dihydroartemisinin-piperaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of EXC 001 to Improve the Appearance of Scars From Prior Breast Surgery
Status: COMPLETED
Conditions: Scar Prevention
Interventions: DRUG: EXC 001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus Treated With Metformin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: AC2993|DRUG: AC2993|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Efficacy of a Novel Approach to Achieving Laparoscopic Distal Rectal Transection for Rectal Cancers
Status: ENROLLING_BY_INVITATION
Conditions: Rectal Neoplasms Malignant
Interventions: PROCEDURE: Transanterior obturator nerve gateway approach|PROCEDURE: Total mesorectal excision approach
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: PROCLAIM-CX-2029: A Trial to Find Safe and Active Doses of an Investigational Drug CX-2029 for Patients With Solid Tumors or DLBCL
Status: COMPLETED
Conditions: Solid Tumor, Adult|Head and Neck Cancer|Non Small Cell Lung Cancer|Diffuse Large B Cell Lymphoma|Esophageal Cancer
Interventions: DRUG: CX-2029
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intracranial Activity of AZD9291 (TAGRISSO) in Advanced EGFRm NSCLC Patients With Asymptomatic Brain Metastases
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: AZD9291
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
Status: RECRUITING
Conditions: Acral Lentiginous Melanoma|Clinical Stage IV Cutaneous Melanoma AJCC v8|Metastatic Cutaneous Melanoma|Metastatic Malignant Neoplasm in the Brain|Metastatic Melanoma|Metastatic Mucosal Melanoma|Pathologic Stage IV Cutaneous Melanoma AJCC v8
Interventions: DRUG: Binimetinib|DRUG: Encorafenib|BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comprehensive Analysis of Spatial, Temporal and Molecular Patterns of Ribociclib Efficacy and Resistance in Advanced Breast Cancer Patients
Status: RECRUITING
Conditions: Breast Cancer|Breast Neoplasms|Breast Neoplasm Female|Breast Cancer Female|HER2-negative Breast Cancer|Hormone Receptor-positive Breast Cancer|Advanced Breast Cancer
Interventions: DRUG: Ribociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography Study Using 2-[18F]-F-A85380 to Determine α4β2 Neuronal Nicotinic Receptor Occupancy of AZD3480 After Oral Administration to Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD3480|RADIATION: 2-[18F]-F-A85380
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MOther-Child Interaction Assessment TRAINING for Pediatricians
Status: RECRUITING
Conditions: Child Behavior Disorders|Mother-child Relations|Depression, Postpartum
Interventions: OTHER: MOCITRAINING program|OTHER: usual follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Magnetic Tape Over Internal Hip Rotation in Patients With Low Back Pain
Status: WITHDRAWN
Conditions: Low Back Pain
Interventions: DEVICE: Magnetic Tape® aplicación|DEVICE: Kinesiology Tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Handheld Vibrator Versus Topical Eye Drops as Anesthesia for Intravitreal Injections
Status: COMPLETED
Conditions: Pain Control During Intravitreal Injections
Interventions: DEVICE: Handheld vibrator triggered during intravitreal injection for wet ARMD|DEVICE: Normal eye esthesiometry with and without vibration|DEVICE: Handheld vibrator not triggered during intravitreal injection for wet ARMD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Panhematin for Prevention of Acute Attacks of Porphyria
Status: TERMINATED
Conditions: Acute Intermittent Porphyria|Hereditary Coproporphyria|Variegate Porphyria
Interventions: BIOLOGICAL: Hemin for injection|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ventilation and Perfusion Scan in Pulmonary Embolism Following Catheter Directed Thrombectomy Versus Anticoagulation Alone
Status: UNKNOWN
Conditions: Pulmonary Embolism|Pulmonary Hypertension|Chronic Thromboembolic Pulmonary Hypertension
Interventions: DEVICE: Catheter directed therapy|DRUG: Systemic anticoagulation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ciclosporin to Protect Renal Function In Cardiac Surgery
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: DRUG: Ciclosporin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Ramelteon Sublingual as Adjunctive Therapy for Maintenance Treatment of Bipolar I Disorder
Status: TERMINATED
Conditions: Bipolar Disorder
Interventions: DRUG: Ramelteon SL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-Label Comparative Study of Risperidone Versus Olanzapine Versus Quetiapine for Mania in Children and Adolescents With Bipolar I and Bipolar II Disorder
Status: COMPLETED
Conditions: Bipolar Spectrum Disorder
Interventions: DRUG: Risperidone|DRUG: Olanzapine|DRUG: Quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: StaphVAX in Cardiovascular Surgery Patients
Status: COMPLETED
Conditions: Staphylococcal Infections|Cardiovascular Diseases|Cardiovascular Surgical Procedures
Interventions: BIOLOGICAL: S. aureus Type 5 & 8 Capsular Polysaccharide Conjugate|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Temozolomide in Patients Affected by Relapsed Sensitive or Refractory Small Cell Lung Cancer With MGMT Methylation
Status: TERMINATED
Conditions: Small Cell Lung Cancer Recurrent
Interventions: DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of MimetikOss in Alveolar Ridge Preservation Previous to Implant Placement
Status: UNKNOWN
Conditions: Alveolar Ridge Preservation
Interventions: DEVICE: MimetikOss (bone grafting surgery)|DEVICE: Bio-Oss (bone grafting surgery)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ezetimibe Versus Placebo in the Treatment of Non-alcoholic Steatohepatitis
Status: COMPLETED
Conditions: Non Alcoholic Steatohepatitis
Interventions: DRUG: Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT