pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pegfilgrastim Versus Filgrastim After High-dose Chemotherapy
Status: COMPLETED
Conditions: Hematological Neoplasms|Tumors
Interventions: DRUG: Filgrastim|DRUG: Pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intranasal Desmopressin vs IV Ketorolac in Renal Colic Pain Control
Status: COMPLETED
Conditions: Renal Colic
Interventions: DRUG: Desmopressin|DRUG: Ketorolac|DRUG: Normal Saline|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: By Using Adoptive Transfer of Autologous NK Cells to Prevent Recurrence of Hepatocellular Carcinoma After Curative Therapy
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: NK cells|OTHER: Curative therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety and Efficacy of Duloxetine in Predominant Stress Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence, Stress
Interventions: DRUG: Duloxetine Hydrochloride|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Timing for Arteriovenous Fistula Creation and Its Effect on Target Organs in Patients With Chronic Renal Failure
Status: UNKNOWN
Conditions: Renal Failure, Chronic
Interventions: PROCEDURE: Lower eGFR for AVF construction|PROCEDURE: Higher eGFR for AVF construction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Security Evaluation of Patients Submitted to Minimally Invasive Radical Prostatectomy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: OTHER: Same day discharge|OTHER: Next-day discharge|OTHER: 2-days discharge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Re-implantation of a Fluocinolone Acetonide Implant for Non-infectious Uveitis Affecting the Posterior Segment
Status: COMPLETED
Conditions: Uveitis
Interventions: DRUG: 0.59 mg Fluocinolone Acetonide implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double Blinded, Randomized Clinical Trial of the Twin Star ECSPRESS Monitoring System for the Reduction of the Incidence of Fasciotomy
Status: UNKNOWN
Conditions: Compartment Syndrome
Interventions: DEVICE: ECSPRESS catheter with active vacuum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Trigger Point Ischemic Compression Massage and Focused Extracorporeal Shoch Wave Therapy of the Patients With Lateral Epicondylitis: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Lateral Epicondylitis
Interventions: OTHER: randomize controlled study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apalutamide in Treating Patients With Prostate Cancer Before Radical Prostatectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Adenocarcinoma|Stage IIB Prostate Cancer AJCC v8
Interventions: DRUG: Apalutamide|OTHER: Quality-of-Life Assessment|PROCEDURE: Radical Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adductor Canal Blockade vs Femoral Nerve Blockade on Muscle Strength, Mobility and Pain After TKA
Status: COMPLETED
Conditions: Mobility After Total Knee Arthroplasty
Interventions: DRUG: Ropivacaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Low-level Laser Therapy in Extensor Tendon Injuries Between Zones 5-8
Status: COMPLETED
Conditions: Tendon Injury - Hand
Interventions: DEVICE: low level laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blood Flow Restriction Exercises and Conservative Exercises in Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis of Knee|Blood Flow Restriction Exercise|Resistance Training|Occlusion Training|Pain, Joint|Hypertrophy
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Primary Care-Based Mindfulness Intervention for Veterans With PTSD
Status: COMPLETED
Conditions: PTSD
Interventions: BEHAVIORAL: Primary Care-Brief Mindfulness Program|BEHAVIORAL: Primary Care-Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison Between Paclitaxel-eluting Balloon in Combination With BMS Implantation vs Conventional Balloon and DES Implantation
Status: TERMINATED
Conditions: Myocardial Ischemia
Interventions: DEVICE: DEB+BMS|DEVICE: POBA+DES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunity and Safety of Covid-19 Synthetic Minigene Vaccine
Status: RECRUITING
Conditions: Pathogen Infection Covid-19 Infection
Interventions: BIOLOGICAL: Injection and infusion of LV-SMENP-DC vaccine and antigen-specific CTLs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modulation of the Gut Microbiome With Pembrolizumab Following Chemotherapy in Resectable Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: PROCEDURE: Biopsy|DRUG: FOLFIRINOX|DRUG: Ciprofloxacin|DRUG: Metronidazole|DRUG: Pembrolizumab|PROCEDURE: Surgical Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of APX-115 in Contrast Induced Acute Kidney Injury in Subjects Undergoing PCI
Status: RECRUITING
Conditions: Contrast Induced Acute Kidney Injury
Interventions: DRUG: Isuzinaxib (APX-115)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Renal Sympathetic Denervation in Mild Refractory Hypertension
Status: COMPLETED
Conditions: Refractory Hypertension
Interventions: DEVICE: Renal sympathetic denervation (Symplicity ablation catheter, Medtronic Inc. Minneapolis, Minnesota, USA)|OTHER: Sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Window of Opportunity Trial: Avelumab in Non-metastatic Muscle Invasive Bladder Cancer
Status: TERMINATED
Conditions: Bladder Cancer|Metastatic Bladder Cancer|Invasive Bladder Cancer
Interventions: DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Episiotomy Scissors and BasIQ-4 Episiotomy Device in Mediolateral Episiotomy
Status: COMPLETED
Conditions: Episiotomy Wound
Interventions: PROCEDURE: Mediolateral Episiotomy with BasIQ-4 Surgical Knife|PROCEDURE: Mediolateral Episiotomy with Episiotomy Scissors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study to Lower the Risk of Heart Failure is Also Effective in Reducing Stiffness of the Arteries
Status: COMPLETED
Conditions: Hypertension|Diabetes
Interventions: DRUG: nebivolol|DRUG: Metoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Pulsatile IV Insulin on Cognition and Amyloid Burden in Patients With Alzheimer's Disease
Status: WITHDRAWN
Conditions: Alzheimer's Disease|Mild Cognitive Impairment
Interventions: DRUG: Insulin LISPRO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Training for PTSD
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: COGENT COGNITIVE TRAINING|BEHAVIORAL: Non training computer condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Saphenous Vein as Y-composite Versus Aortocoronary Conduit for CABG
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Y-composite grafting|PROCEDURE: Aortocoronary grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycan Mediated Immune Regulation With a Bi-Sialidase Fusion Protein (GLIMMER-01)
Status: ACTIVE_NOT_RECRUITING
Conditions: Oncology|Melanoma|Ovarian Cancer|NSCLC|Non Small Cell Lung Cancer|Colorectal Cancer|Pancreatic Cancer|Cancer|CRC|Colon Cancer|Breast Cancer|Gastric Cancer|EGJ|Esophagogastric Junction Cancer|Head and Neck Cancer|Urothelial Cancer|Bladder Cancer
Interventions: BIOLOGICAL: E-602|BIOLOGICAL: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Persistence of MR3 in Chronic Myeloid Leukemia (CML) After a 2nd Stop of TKI Treatment
Status: UNKNOWN
Conditions: CML, Relapsed
Interventions: DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Air Cold Atmospheric Pressure Plasma Treatment for Acceleration of Venous Ulcer Healing
Status: RECRUITING
Conditions: Venous Leg Ulcer
Interventions: DEVICE: Cold Atmospheric Plasma Jet Treatment|DEVICE: Alginate Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial of Polyester vs. Polyurethane Patch for Carotid Endarterectomy
Status: COMPLETED
Conditions: Carotid Artery Thrombosis|Carotid Artery Stenosis|Stroke
Interventions: PROCEDURE: CEA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Depression Prevention in Older Spousally-bereaved Adults
Status: RECRUITING
Conditions: Depression
Interventions: BEHAVIORAL: WIdowed Elders' LIfestyle after Loss (WELL)|OTHER: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Understanding How Ketamine Brings About Rapid Improvement in OCD
Status: ACTIVE_NOT_RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: Ketamine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypotension Prediction With HPI Algorithm During Decessed-donor Kidney Transplant (HPI2022)
Status: RECRUITING
Conditions: Hypotension During Surgery|Kidney Transplant; Complications
Interventions: DEVICE: ACUMEN (Edwards Lifesciences, Irvine, USA)|DEVICE: Invasive Blood Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Enzalutamide Plus Androgen Deprivation Therapy (ADT) Versus Placebo Plus ADT in Patients With Metastatic Hormone Sensitive Prostate Cancer (mHSPC)
Status: COMPLETED
Conditions: Metastatic Hormone Sensitive Prostate Cancer
Interventions: DRUG: Enzalutamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rucaparib in Treating Patients With Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Deleterious BRCA1 Gene Mutation|Deleterious BRCA2 Gene Mutation|Loss of Heterozygosity|Lung Non-Small Cell Squamous Carcinoma|Recurrent Large Cell Lung Carcinoma|Recurrent Lung Adenocarcinoma|Recurrent Lung Non-Small Cell Carcinoma|Recurrent Non-Squamous Non-Small Cell Lung Carcinoma|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: DRUG: Rucaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AIMSPRO in the Treatment of Bladder Dysfunction in Secondary Progressive Multiple Sclerosis
Status: UNKNOWN
Conditions: Secondary Progressive Multiple Sclerosis
Interventions: DRUG: Hyperimmune caprine serum against HIV lysate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Efficacy of Long-Term Rilonacept Treatment for the Prevention of Gout Flares
Status: TERMINATED
Conditions: Gout
Interventions: DRUG: Rilonacept|DRUG: Placebo|DRUG: Allopurinol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of Hecolin® in HIV Positive/Negative Adults and in Children
Status: NOT_YET_RECRUITING
Conditions: Hepatitis E Virus Infection
Interventions: BIOLOGICAL: Hecolin® Recombinant Hepatitis E Vaccine|BIOLOGICAL: Isotonic Sodium Chloride injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Low-Dose Decitabine in Relapsed or Refractory Acute Lymphocytic Leukemia (ALL)
Status: COMPLETED
Conditions: Acute Lymphocytic Leukemia
Interventions: DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TACE With Dicycloplatin(TP21) in Unresectable HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: cTACE|DRUG: Dicycloplatin (TP21)|DRUG: Epirubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Black Stains' Epidemiology, Clinical Evaluation and Dietary Habits: a Clinical Trial.
Status: COMPLETED
Conditions: Black Stains
Interventions: OTHER: Lactoferrin products|OTHER: Probiotics products|OTHER: Standard home oral care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Polycystic Ovary Syndrome (PCOS) and Sleep Apnea
Status: TERMINATED
Conditions: Polycystic Ovary Syndrome|Obstructive Sleep Apnea
Interventions: DEVICE: continuous positive airway pressure (CPAP)|DRUG: depot leuprolide plus estrogen/progestin replacement|DRUG: pioglitazone|PROCEDURE: REM frag|PROCEDURE: SWS supp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Lateral and Vertical Tissue Displacement Obtained by the Retraction Cord and Diode Laser
Status: UNKNOWN
Conditions: Endodontically-Treated Teeth|Spacing of Anterior Maxillary Teeth|Broken Teeth Injury With Complication
Interventions: DEVICE: diode laser|DEVICE: ultrapak Knitted retraction cord
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Non-invasive Magnetic Stimulation of the Brain on Breathlessness in Healthy Individuals.
Status: RECRUITING
Conditions: Dyspnea
Interventions: DEVICE: Sham or actual non-invasive (Magnetic) brain stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluating the Effects of an Exercise Intervention on the Gut Microbiota in Stage II-III Colorectal Cancer Survivors
Status: RECRUITING
Conditions: Stage II Colorectal Cancer AJCC v8|Stage III Colorectal Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Exercise Intervention|OTHER: Exercise Intervention|BEHAVIORAL: Health Education|OTHER: Interview|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pain in Patients With Dementia and Behavioural Disturbances
Status: COMPLETED
Conditions: Dementia|Pain|Agitation
Interventions: DRUG: Paracetamol|DRUG: Morphine|DRUG: Buprenorphine plaster|DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mirtazapine Versus Placebo in Functional Dyspepsia
Status: COMPLETED
Conditions: Functional Dyspepsia
Interventions: DRUG: Mirtazapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: How Early Mobilization Impacts on Diaphragm Thickness in Critically Ill Children
Status: RECRUITING
Conditions: Mechanical Ventilation Complication|Ventilator-induced Diaphragm Dysfunction
Interventions: OTHER: early mobilization|OTHER: routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy of PDR001 in Patients With Squamous Cell Carcinoma of the Esophagus
Status: UNKNOWN
Conditions: Histologically Confirmed Unresectable or Metastatic Squamous Cell Carcinoma of the Esophagus Who Failed on Standard Treatment
Interventions: DRUG: PDR001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of HIVAX in HIV-1 Infected Subjects
Status: UNKNOWN
Conditions: HIV Infections
Interventions: BIOLOGICAL: HIVAX|BIOLOGICAL: saline solution|BIOLOGICAL: HIVAX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transdermal Delivery of Glucosamine to the Synovial Fluid of Male and Female With Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Transdermal Glucosamine Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tumor Cell Vaccines and ISCOMATRIX With Chemotherapy After Tumor Removal
Status: TERMINATED
Conditions: Sarcoma|Melanoma|Epithelial Malignancies|Pleural Malignancy
Interventions: BIOLOGICAL: Epigenetically Modified Autologous Tumor|DRUG: Cyclophosphamide|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II-III Clinical Trial of PD1 Antibody (Toripalimab), Lenvatinib and GEMOX Neoadjuvant Treatment for Resectable Intrahepatic Cholangiocarcinoma With High-risk Recurrence Factors
Status: RECRUITING
Conditions: Intrahepatic Cholangiocarcinoma|PD1 Antibody|Lenvatinib|Gemox Chemotherapy
Interventions: DRUG: Neoadjuvant treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Negative Pressure Ventilation-rehabilitation on Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|Acute Exacerbation of COPD
Interventions: DEVICE: cuirass ventilator (cuirass diameter 21 cm or 34 cm, Dima Italia Srl.,Bologna, Italy)|BEHAVIORAL: breathing training, and an educational program (relaxation techniques and a home pacing walking exercise)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: L3/L4 High Velocity Low Amplitude Technique Influence On Baropodometric Pressures In Healthy Young Adults
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: OTHER: HVLA L3/4|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Neo-adjuvant Peptide Receptor Mediated Radiotherapy With 177Lutetium in Front of Curative Intended Liver Transplantation in Patients With Hepatic Metastasis of Neuroendocrine Tumors (NEO-LEBE)
Status: UNKNOWN
Conditions: Liver|Metastasis|Neuroendocrine Tumors
Interventions: RADIATION: 177Lutetium|PROCEDURE: Liver transplantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Feasibility Trial of Sisterhood 2.0
Status: COMPLETED
Conditions: Adolescent Behavior|Violence in Adolescence|Group, Peer|Violence, Non-accidental|Violence, Sexual|Violence, Physical|Violence, Domestic|Emotional Abuse|Coping Skills|Communication, Personal
Interventions: BEHAVIORAL: Sisterhood 2.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Compare the Effectiveness and Safety of Two Different Kinds of Cutting Balloon in Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Stenosis|Coronary Artery Stenosis|In-stent Restenosis
Interventions: DEVICE: SINOMED CBC|DEVICE: NSE Coronary Dilatation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fractional Co2 Laser Versus Microbotox Injection in the Treatment of Wide Facial Pores: A Split Face Comparative Study
Status: NOT_YET_RECRUITING
Conditions: Skin Abnormalities
Interventions: DRUG: microbotox|RADIATION: fractional carbon dioxide laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Reversal of Neuromuscular Adaptation in Human With Spinal Cord Injury II
Status: UNKNOWN
Conditions: Spinal Cord Injury(SCI)
Interventions: DEVICE: home-based ankle continuous passive motion machine.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Dose Escalation Study In Medically Stable Subjects With Psoriasis
Status: COMPLETED
Conditions: Psoriasis|Immunomodulation
Interventions: DRUG: tofacitinib|DRUG: tofacitinib|DRUG: tofacitinib|DRUG: tofacitinib|DRUG: tofacitinib|DRUG: tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Tinzaparin for Anticoagulation in Hemodialysis
Status: COMPLETED
Conditions: Kidney Failure, Chronic
Interventions: DRUG: Tinzaparin|DRUG: Unfractionated Heparin|DRUG: Placebo (for Tinzaparin)|DRUG: Placebo (for Unfractionated Heparin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Chemotherapy for Patients With Squamous Cell Carcinoma of the Penis
Status: COMPLETED
Conditions: Penile Cancer
Interventions: DRUG: Ifosfamide|DRUG: Paclitaxel (Taxol)|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subclinical Hypothyroidism and Chronic Inflammation in PCOS
Status: RECRUITING
Conditions: PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries|Subclinical hypothyroïdism|Hypothalamic-Pituitary-Gonadal Axis Dysfunction
Interventions: DIAGNOSTIC_TEST: Measurement and comparison of leucocytosis and concentrations of CRP, procalcitonin, fibrinogen, ferritin, IL-1, IL-6, IL-10, TNF-alpha in both study arms|DIAGNOSTIC_TEST: Evaluation of the impact of subclinical hypothyroidism, with present/ absent antithyroid antibodies, on the balance between anti- and pro-inflammatory factors in women in both study arms|DIAGNOSTIC_TEST: Assessment of the impact of imbalance between anti- and pro-inflammatory factors in women with different PCOS and HPOD phenotypes on ovarian reserve indices
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cone Rescue in Retinitis Pigmentosa by the Treatment of Lycium Barbarum
Status: COMPLETED
Conditions: Retinitis Pigmentosa
Interventions: DIETARY_SUPPLEMENT: Lycium Barbarum|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-Institutional Pilot Study of Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Malignant Neuro-Epithelial and Other Solid Tumors
Status: TERMINATED
Conditions: Neuroepithelial Tumor|Solid Tumor|Allogeneic Hematopoietic Stem Cell Transplantation
Interventions: PROCEDURE: Allogeneic hematopoietic stem cell transplant following thiotepa-based marrow ablative chemotherapy|DRUG: Keratinocyte Growth Factor|DRUG: Alemtuzumab|DRUG: Thiotepa|DRUG: Etoposide|DRUG: Fludarabine|DRUG: Melphalan|DRUG: Tacrolimus|DRUG: Cyclosporine A|DRUG: Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flavanol Augmentation for Antidepressant Non-Responsive Late Life Depression
Status: TERMINATED
Conditions: Depression|Major Depressive Disorder
Interventions: DIETARY_SUPPLEMENT: CocoaVia|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: mHealth for Prevention of Childhood Obesity in Mexico
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: OTHER: Control group|BEHAVIORAL: SMS´s sending by cell phone for behavior change
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Abrilumab (AMG 181) in Adults With Moderate to Severe Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: Abrilumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Microbiome Alterations With Xylitol (MAX) in Pregnancy
Status: RECRUITING
Conditions: Dysbiosis|Inflammation Gum
Interventions: DIETARY_SUPPLEMENT: Xylitol gum|DIETARY_SUPPLEMENT: Sorbitol gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Evaluation of Belimumab in Myasthenia Gravis (MG)
Status: COMPLETED
Conditions: Myasthaenia Gravis
Interventions: BIOLOGICAL: Belimumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Immunogenicity of Intramuscular Full-Dose and Intradermal Fractional Dose of IPV
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: IPV|BIOLOGICAL: f-IPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Kg-Free: an Acceptance, Mindfulness and Compassionate-based Intervention for Women Struggling With Their Weight
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: BEHAVIORAL: Kg-Free|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Assess the Tolerability and Safety of Ecallantide in Children and Adolescents With Hereditary Angioedema
Status: WITHDRAWN
Conditions: Hereditary Angioedema Types I and II
Interventions: DRUG: Ecallantide subcutaneous dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of QTRAC Technique to Measure Axonal Excitability in Anti-MAG Neuropathy
Status: TERMINATED
Conditions: Peripheral Neuropathy Associated With Anti-myelin Associated Glycoprotein Antibodies (Anti-MAG Neuropathy)
Interventions: OTHER: QTRAC assessment|OTHER: Clinical assessment of peripheral nerve function
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Randomized Control Trial of Small-Molecule Natural Flavonoids Intervention for Neurodegenerative Diseases
Status: NOT_YET_RECRUITING
Conditions: Neurodegenerative Diseases
Interventions: DIETARY_SUPPLEMENT: SMARTO ONE|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Cilostazol in Prevention of Peripheral Neuropathy
Status: COMPLETED
Conditions: Peripheral Neuropathy|Breast Cancer
Interventions: DRUG: Cilostazol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Long-term Safety Study of Infliximab in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD).
Status: COMPLETED
Conditions: COPD|Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Collection of safety data for Cohort 1
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Primary Prophylaxis of Gastric Varix Bleed
Status: COMPLETED
Conditions: Cirrhosis
Interventions: PROCEDURE: Endoscopic cyanoacrylate injection|DRUG: Beta-blocker (propranolol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Minocycline to Reduce Pain After Carpal Tunnel Release
Status: COMPLETED
Conditions: Chronic Pain|Post-operative Pain
Interventions: DRUG: Minocycline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Virtual Reality to Reduce Pre-procedure Anxiety Prior ECT
Status: RECRUITING
Conditions: ECT|Electroconvulsive Therapy|Virtual Reality|Anxiety|Education|Hemodynamics|Depression|Cognition|Mental Health
Interventions: OTHER: VR-ECT 360o Video|OTHER: Standard Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Vitamin-D Supplementation: Impact on Severe Pneumonia Among Under-five Children
Status: COMPLETED
Conditions: Pneumonia
Interventions: DRUG: Vitamin D3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation in Patients With Mild Cognitive Impairment - RCT Trial
Status: RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: DEVICE: TMS|DEVICE: TMS|DEVICE: TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adrenergic Blockers for Cardiac Changes in Early Parkinson's Disease (Protocol 53136)
Status: RECRUITING
Conditions: REM Sleep Behavior Disorder|Pre-motor Parkinson Disease|Symptomatic Parkinson Disease
Interventions: DRUG: Carvedilol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of a Booster Dose of GSK Biologicals' 10-valent Pneumococcal Conjugate Vaccine.
Status: COMPLETED
Conditions: Infections, Streptococcal
Interventions: BIOLOGICAL: Synflorix|BIOLOGICAL: Prevenar|BIOLOGICAL: Infanrix hexa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: PREVENTION
Clinical trial: Study of Fixed-Dose Combinations of Trabodenoson and Latanoprost in Adults With OHT or POAG
Status: COMPLETED
Conditions: Primary Open-Angle Glaucoma (POAG)|Ocular Hypertension (OHT)
Interventions: DRUG: trabodenoson 6.0% / latanoprost 0.005% QD|DRUG: trabodenoson 3.0% / latanoprost 0.005% QD|DRUG: trabodenoson 6.0% / latanoprost 0.0025% QD|DRUG: latanoprost 0.005% QD|DRUG: latanoprost 0.0025% QD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of F-18 Paclitaxel (FPAC) PET for Evaluating Drug Delivery of Solid Tumors in Breast, Lung, Renal, and Adrenal Cancers
Status: TERMINATED
Conditions: Breast Cancer|Lung Cancer|Renal Cancer|Adrenal Cancer
Interventions: DRUG: FPAC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pilot Human Study of Tinidazole Efficacy For Radical Cure Of Plasmodium Vivax
Status: COMPLETED
Conditions: Malaria, Vivax
Interventions: DRUG: Tinidazole|DRUG: chloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telehealth-Enabled, Real-time Audit and Feedback for Clinician AdHerence (TEACH)
Status: RECRUITING
Conditions: Respiration, Artificial
Interventions: OTHER: Telehealth- enabled support for SAT/SBT adherence|OTHER: Usual audit and feedback for SAT/SBT adherence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Long-term Safety and Efficacy Study of DX-2930 (SHP643) to Prevent Acute Angioedema Attacks in Patients With Type I and Type II HAE
Status: COMPLETED
Conditions: Hereditary Angioedema (HAE)
Interventions: DRUG: DX-2930|DRUG: DX-2930
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase II Study of Metastatic Melanoma With Lymphodepleting Conditioning and Anti-gp100:154-162 TCR Gene Engineered Lymphocytes
Status: TERMINATED
Conditions: Skin Cancer|Melanoma
Interventions: DRUG: fludarabine phosphate|DRUG: cyclophosphamide|BIOLOGICAL: aldesleukin|BIOLOGICAL: autologous anti-gp 100:154-162 T-cell receptor gene-engineered tumor infiltrating lymphocytes|BIOLOGICAL: autologous anti-gp 100:154-162 T-cell receptor gene-engineered peripheral blood lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Febuxostat on Coronary Artery Endothelial Dysfunction in Participants With Chronic Stable Angina
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Febuxostat|DRUG: Febuxostat placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Azithromycin as Immunomodulatory Therapy in Grave&Apos;s Orbitopathy
Status: WITHDRAWN
Conditions: Graves Ophthalmopathy
Interventions: DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET Imaging With 89Zr-DFO-Trastuzumab in Esophagogastric Cancer
Status: COMPLETED
Conditions: Esophagogastric Cancer
Interventions: RADIATION: 89Zr-DFO-trastuzumab|DEVICE: PET imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Diagnostic Significance of CTCs in Patients With Thyroid Nodules (Circulating Tumor Cells)
Status: UNKNOWN
Conditions: Thyroid Nodule|Diagnoses Disease
Interventions: DIAGNOSTIC_TEST: circulating tumor cells test|DIAGNOSTIC_TEST: Fine needle aspiration biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CAREGIVER: A Trial to Improve the Burden and Distress of Caring for Persons With Decompensated Cirrhosis
Status: COMPLETED
Conditions: Caregivers
Interventions: BEHAVIORAL: Written emotional disclosure|BEHAVIORAL: Resilience training|OTHER: No treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention Support for People Leaving Jail
Status: COMPLETED
Conditions: HIV Infections|Sexually Transmitted Diseases, Bacterial|Hepatitis C|Substance Use Disorders
Interventions: BEHAVIORAL: Mobile Enhanced Prevention Support|BEHAVIORAL: Usual Care plus Customized Referrals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Quadratus Lumborum Block : Local Anesthesia Versus Placebo
Status: RECRUITING
Conditions: Loop Ileostomy|Colorectal Disorders
Interventions: PROCEDURE: Quadratus lumborum block using ropivacaine|PROCEDURE: Quadratus lumborum block with normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Group Therapy for Women Prisoners With Comorbid Substance Use and Depression
Status: COMPLETED
Conditions: Substance Abuse|Substance Dependence|Depressive Disorder
Interventions: BEHAVIORAL: Group interpersonal psychotherapy (IPT-G)|BEHAVIORAL: Psychoeducation on co-occurring disorders (PSYCHOED)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-omics Sequencing in Neoadjuvant Immunotherapy of Gastrointestinal Tumors
Status: RECRUITING
Conditions: Immunotherapy|Gastric Cancer|Rectal Cancer|Chemotherapy Effect|Radiotherapy
Interventions: DRUG: Terelizumab (aka Tislelizumab)|DRUG: CapeOx|DRUG: Trastuzumab|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tipifarnib in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome|Adult Acute Erythroid Leukemia (M6)|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monoblastic Leukemia and Acute Monocytic Leukemia (M5)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Recurrent Adult Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: tipifarnib|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2a Pharmacodynamic Study of TAK-448 in Participants With Hypogonadotropic Hypogonadism
Status: TERMINATED
Conditions: Hypogonadotropic Hypogonadism
Interventions: DRUG: TAK-448
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study To Evaluate The Effects of Everolimus on Brain mTOR Activity and Cortical Hyperexcitability in TSC and FCD
Status: COMPLETED
Conditions: Epilepsy|Tuberous Sclerosis Complex|Focal Cortical Dysplasia
Interventions: DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Artificial Intelligence-powered Virtual Assistant for Emergency Triage in Neurology
Status: COMPLETED
Conditions: Stroke|Guillain-Barre Syndrome|Facial Palsy|Migraine|Status Epilepticus|Vertigo Benign Positional|Delirium|Trigeminal Neuralgia|Meningitis|Subarachnoid Hemorrhage
Interventions: DIAGNOSTIC_TEST: Virtual Assistant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Non-invasive Diagnostics and Monitoring of MRD and Clonal Evolution in Waldenström's Macroglobulinemia and in IgM-MGUS
Status: ACTIVE_NOT_RECRUITING
Conditions: Waldenstrom Macroglobulinemia
Interventions: OTHER: MRD and clonal evolution
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Zevalin With Non Myeloablative Allogeneic Stem Cell Transplantation in Patients With Non Hodgkin Lymphoma
Status: UNKNOWN
Conditions: Non-Hodgkins Lymphoma
Interventions: DRUG: Rituximab|DRUG: 90Y ibritumomab tiuxetan (Zevalin)|DRUG: Cyclophosphamide|DRUG: Fludarabine|OTHER: Non myeloablative allogeneic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas
Status: COMPLETED
Conditions: Brain Tumor, Recurrent|Glioblastoma|Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|Mixed Glioma
Interventions: PROCEDURE: Cytoreductive surgery|DRUG: Perifosine|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rifaximin for Preventing Acute Graft Versus Host Disease (AGVHD)
Status: COMPLETED
Conditions: Malignancy|Bone Marrow Transplantation
Interventions: DRUG: Rifaximin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose-escalation Study of Lipotecan® Plus Radiotherapy in Locally Advanced Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Lipotecan® (TLC388)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess the Effect of Naproxcinod Versus Naproxen and Ibuprofen on Arterial Blood Pressure in Osteoarthritis Patients With Controlled Essential Hypertension
Status: COMPLETED
Conditions: Osteoarthritis|Hypertension
Interventions: DRUG: naproxcinod 375 mg bid|DRUG: naproxcinod 750 mg bid|DRUG: naproxen 250 mg bid|DRUG: naproxen 500 mg bid|DRUG: ibuprofen 600 mg tid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 1
Status: COMPLETED
Conditions: Alcohol Use|Drug Use|Risk Behavior|Sexual Behavior
Interventions: BEHAVIORAL: Contingency management|BEHAVIORAL: Employment Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing Neurovisual Function in Patients With Cognitive Impairment
Status: UNKNOWN
Conditions: Glaucoma|Mild Cognitive Impairment|Glaucoma and Mild Cognitive Impairment|Healthy
Interventions: DEVICE: Ocusweep test battery|DIAGNOSTIC_TEST: Neuropsychological test battery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Patient-based Care Versus Standard Care for Patients With hEDS/HSD and Multidirectional Shoulder Instability
Status: TERMINATED
Conditions: Hypermobile Ehlers-Danlos Syndrome|Hypermobility Syndrome|Multidirectional Subluxation of Shoulder
Interventions: OTHER: Tailored home-based exercise therapy|OTHER: Standard home-based exercise therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Ultrasound (EUS) Guided Treatment With Humira for Crohn's Perianal Fistulas
Status: COMPLETED
Conditions: Crohn Disease|Rectal Fistula
Interventions: PROCEDURE: EUA with seton placement if necessary|DRUG: adalimumab|PROCEDURE: EUS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: HIV Rapid Testing & Counseling in Sexually Transmitted Disease (STD) Clinics in the U.S.
Status: COMPLETED
Conditions: HIV/AIDS|Sexually Transmitted Infections
Interventions: BEHAVIORAL: RESPECT-2 Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING