pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Learn How Well Nifurtimox Works and How Safe it is in Children Aged 0 to 17 Years With Chagas' Disease, an Inflammatory, Infectious Disease Caused by the Parasite Trypanosoma Cruzi
Status: COMPLETED
Conditions: Chagas Disease
Interventions: DRUG: Nifurtimox (Lampit, BAYA2502)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Fraction High-Gradient Partial Breast Irradiation in Treating Patients With Low-Risk Stage 0-I Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: RADIATION: accelerated partial breast irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Effect of a High-Fat Meal on the Relative Bioavailability and Pharmacokinetics of a Single Dose of Bosutinib Administered Orally to Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Bosutinib|DRUG: Bosutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Recovery of Cardiovascular Patients With Depression
Status: UNKNOWN
Conditions: Coronary Artery Disease|Depression|Cardiovascular Diseases
Interventions: DRUG: Psychiatric treatment with sertraline|DRUG: Psychiatric treatment with escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 VAX Booster Dosing in Patients With Hematologic Malignancies
Status: COMPLETED
Conditions: Multiple Myeloma|AL Amyloidosis|Chronic Lymphocytic Leukemia
Interventions: DRUG: A single "booster" dose of the Moderna mRNA COVID-19 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Diacutaneous Fibrolysis Over Neuromuscular Response
Status: UNKNOWN
Conditions: Myofascial Pain Syndrome|Contraction
Interventions: OTHER: Diacutaneous fibrolysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use and Acceptability Study of Swallis DSA™ Device for Distanced Swallowing Assessment for Older Adults In Nursing Home CHEZ LES PERSONNES AGEES EN EHPAD
Status: UNKNOWN
Conditions: Dysphagia
Interventions: OTHER: Swallowing assessment with Swallis DSA™ Device
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Use of Duloxetine for Cognition Improvement in Individuals With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Depression
Interventions: DRUG: Duloxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Performance Evaluation of the DualDur In Vitro Diagnostic System in the Diagnosis of Lyme Borreliosis
Status: COMPLETED
Conditions: Lyme Borreliosis
Interventions: DIAGNOSTIC_TEST: DualDur dark-field microscopic test|DIAGNOSTIC_TEST: DualDur dark-field automatic microscopic test|DIAGNOSTIC_TEST: Western blot IgM and IgG|DIAGNOSTIC_TEST: Bózsik Western blot IgM and IgG|DIAGNOSTIC_TEST: enzyme-linked immunosorbent assay (ELISA) IgM and IgG|DIAGNOSTIC_TEST: DualDur Polymerase chain reaction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Endometrial Cancer Lymphadenectomy Trial
Status: RECRUITING
Conditions: Cancer of Endometrium Stage I|Cancer of Endometrium Stage II
Interventions: PROCEDURE: Standard surgical procedure for endometrial cancer|PROCEDURE: systematic lymphadenectomy (LNE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Vigiis 101-LAB on a Healthy Populations' Gut Microflora
Status: COMPLETED
Conditions: Gastrointestinal Microbiome
Interventions: DIETARY_SUPPLEMENT: Vigiis 101-LAB|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Transversus Abdominis Plane Block Combined With Dexmedetomidine Infusion on the Prognosis in Elderly Patients Undergoing Abdominal Surgery
Status: UNKNOWN
Conditions: Colorectal Neoplasms|Aged
Interventions: PROCEDURE: Transversus abdominis plane block using ropivacaine|DRUG: Dexmedetomidine|PROCEDURE: Transversus abdominis plane block using saline|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Pilot Study of Motor Control Exercise and Patient Education for the Management of Chronic Low Back Pain in Rural Nigerian Community.
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: BEHAVIORAL: Motor Control Exercise|BEHAVIORAL: Patient Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effects of Fasinumab on Peripheral Nerve Function in Patients With Pain Due to Osteoarthritis of the Hip or Knee
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Osteoarthritis, Hip
Interventions: DRUG: Fasinumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 4: Investigational Study to Evaluate Metformin XR Monotherapy Versus Metformin IR Monotherapy in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Metformin XR|DRUG: Metformin IR|DRUG: Placebo matching with Metformin XR|DRUG: Placebo matching with Metformin IR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Active Intervention At Diagnosis With Usual Care to Improve Psycho-social Care in AYAO
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma|Lymphoma|Sarcoma|Cancer
Interventions: OTHER: Supportive Care Program|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study for the Investigation and Validation of a Therapy Procedure for the Adjustment of Risk Factors in Patients With Coronary Heart Disease by Means of Digital Therapy Control
Status: RECRUITING
Conditions: Coronary Artery Disease|Cardiovascular Diseases|Coronary Heart Disease|Ischemic Heart Disease
Interventions: DEVICE: CHD therapy through iATROS medical device
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial to Evaluate Efficacy and Safety of ROVASRO 10mg Versus CRESTOR 10mg in Hypercholesterolemic Patients
Status: COMPLETED
Conditions: Hypercholesterolemia|Dyslipidemias
Interventions: DRUG: CRESTOR, reference formulation of rosuvastatin|DRUG: ROVASRO, generic formulation of rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vanderbilt Pertussis Exposure Study: PEP in Vaccinated Healthcare Workers Following Pertussis Exposure
Status: COMPLETED
Conditions: Pertussis
Interventions: DRUG: Antibiotic PEP|DRUG: Antibiotic PEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cumulative Skin Irritation Potential of a New 25 mg Nicotine Patch
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Nicotine Patch|DRUG: Placebo Patch|DRUG: SLS Comparator Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Open-Label Phase IIb Efficacy Trial of Cancer Macrobeads Compared to Best Supportive Care in Colorectal Cancer Patients
Status: COMPLETED
Conditions: Colorectal Cancers
Interventions: BIOLOGICAL: RENCA macrobeads
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor Natural Killer Cells in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Recurrent Adult Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Cytarabine|BIOLOGICAL: Filgrastim|BIOLOGICAL: Filgrastim-sndz|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Membrane-bound Interleukin-21-Expanded Haploidentical Natural Killer Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maximizing Acute Kidney Injury End-point Intervention Post-Discharge (MAKE-IT) Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Kidney Injury
Interventions: OTHER: Medication reconciliation|OTHER: Blood Pressure Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab Maintenance in Newly Diagnosed PCNSL With Persistent CSF Circulating Tumor DNA After Completion of First-Line Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Central Nervous System Lymphoma (PCNSL)
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Six Month Study of Gentamicin in Duchenne Muscular Dystrophy With Stop Codons
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: Gentamicin infusions twice a week for six months
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-arm Phase II Trial of SAcituzumab Govitecan and Trastuzumab for HER2+ Metastatic Breast Cancer After Trastuzumab dEruxtEcaN (SATEEN)
Status: RECRUITING
Conditions: Her 2 Positive Breast Cancer|Breast Cancer Female|Breast Cancer Metastatic
Interventions: DRUG: Sacituzumab Govitecan|DRUG: Trastuzumab|DRUG: Trastuzumab and Hyaluronidase-oysk
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OPC-1085EL in the Treatment of Primary Open Angle Glaucoma or Ocular Hypertension in Chinese Subjects
Status: RECRUITING
Conditions: Open Angle Glaucoma or Ocular Hypertension
Interventions: DRUG: OPC-1085EL|DRUG: 0.005% Latanoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Acamprosate in Alcoholics With Comorbid Anxiety or Depression
Status: COMPLETED
Conditions: Alcohol Dependence|Major Depression|Social Anxiety Disorder|Generalized Anxiety Disorder
Interventions: DRUG: Acamprosate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Tolerability of ABO/MEG-B-09 in Children With Acute Cough
Status: COMPLETED
Conditions: Cough
Interventions: DEVICE: AboMeg-B-09|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does a Virtual Coach Offer a Better Solution for Weight Reduction in Ventral Hernia Patients With Obesity?
Status: RECRUITING
Conditions: Obesity|Ventral Hernia
Interventions: OTHER: MyChart enabled virtual weight loss coach|OTHER: Standard preoperative weight loss tools
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of MTS Versus Concerta in Pediatric Patients (Aged 6-12 Years) With ADHD
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Methylphenidate Transdermal System|DRUG: Placebo|DRUG: Concerta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outcome of Combined Tramadol and Paracetamol Versus Pentazocine as Labour Analgesia Among Parturients
Status: UNKNOWN
Conditions: Labor Pain
Interventions: DRUG: Pentazocine plus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 2 Study of Sitravatinib in Combination With PD-(L)1 Checkpoint Inhibitor Regimens in Patients With Advanced or Metastatic Urothelial Carcinoma
Status: TERMINATED
Conditions: Urothelial Carcinoma|Urothelial Carcinoma Bladder|Urothelial Carcinoma Ureter|Urothelial Carcinoma of the Renal Pelvis and Ureter|Urothelial Carcinoma Urethra
Interventions: DRUG: Sitravatinib|DRUG: Nivolumab|DRUG: Pembrolizumab|DRUG: Enfortumab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Exposure Reduction in Supraventricular Tachycardia Ablation
Status: COMPLETED
Conditions: Supraventricular Tachycardias
Interventions: PROCEDURE: Radiofrequency catheter ablation|PROCEDURE: Radiofrequency catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Psilocybin for Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Psilocybin|DRUG: Niacin|OTHER: Set and Setting (SaS) Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Online Trial Examining Validity of the Shared Decision Making Process Survey With Video Vignettes
Status: COMPLETED
Conditions: Colorectal Cancer|High Cholesterol
Interventions: BEHAVIORAL: Good high cholesterol video|BEHAVIORAL: Poor high cholesterol video|BEHAVIORAL: Good colon cancer screening video|BEHAVIORAL: Poor colon cancer screening video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Microclinic Social Network Behavioral Health Trial in Jordan
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Obesity|Hypertension|Hyperglycemia|Blood Pressure|Hyperglycaemia (Diabetic)|Body Weight|Weight Loss|Weight, Body|Weight Change Trajectory|Weight Change, Body|Weight Gain|Blood Pressure, High|Social Behavior|Behavior, Health|Lifestyle Risk Reduction|Lifestyle, Healthy|Diabetes|Diabetes Mellitus|Glucose, High Blood
Interventions: BEHAVIORAL: Microclinic Behavioral Health Full Program (education curriculum in classroom setting, plus full social interaction program)|BEHAVIORAL: Microclinic Behavioral Health Basic Program (education-only in classroom setting; no structured social interactions)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Vascular Stiffness in ADPKD
Status: RECRUITING
Conditions: Autosomal Dominant Polycystic Kidney
Interventions: DIETARY_SUPPLEMENT: Sodium chloride (NaCl)|DIETARY_SUPPLEMENT: Placebo|DRUG: Amiloride Hcl 5mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2a Trial of FOL-005 Topical Formulations to Investigate Hair Growth Potential and Safety in Healthy Male Volunteers
Status: COMPLETED
Conditions: Androgenetic Alopecia
Interventions: DRUG: Topical formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of 68Ga-HX01 Injection for PET Imaging
Status: COMPLETED
Conditions: Healthy|Malignancy
Interventions: DRUG: 68Ga-HX01 Injection(0.05mCi/kg)|DRUG: 68Ga-HX01 Injection(0.1mCi/kg)|DRUG: 68Ga-HX01 Injection(0.07mCi/kg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Low-level Laser at Auriculotherapy Points to Reduce Postoperative Pain in Inferior Third Molar Surgery
Status: UNKNOWN
Conditions: Pain
Interventions: DEVICE: low level laser in auricular acupuncture points|DEVICE: low level laser device off in auricular acupuncture points
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gabapentin in Treating Hot Flashes in Patients With Prostate Cancer
Status: COMPLETED
Conditions: Hot Flashes|Prostate Cancer
Interventions: DRUG: gabapentin|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Repetitive Transcranial Magnetic Stimulation in Obsessive Compulsive Disorder
Status: UNKNOWN
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: Active Repetitive Transcranial Magnetic Stimulation|DEVICE: Placebo Repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Initiation of Acid Suppression Therapy Prospective Outcomes for Laryngomalacia
Status: TERMINATED
Conditions: Laryngomalacia|Gastro Esophageal Reflux
Interventions: DRUG: Famotidine|OTHER: Speech Language Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ABT-165 in Subjects With Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: paclitaxel|DRUG: FOLFIRI|DRUG: ABT-165|DRUG: ABBV-181
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Two Application Regimens of Amniotic Membrane Wound Graft In the Management of Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: OTHER: Weekly application of EpiFix plus standard of care|OTHER: Biweekly application of EpiFix plus standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Characterization of the Heart, Aorta and Blood Pressure in Turner Syndrome. Association With Aortic Dissection.
Status: UNKNOWN
Conditions: Turner Syndrome|Aortic Aneurysm|Ischemic Heart Disease|Hypertension|Congenital Heart Defect
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 1 Study to Determine Safety, Blood PK and Lung Penetration
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: ACHN-490 Injection|DRUG: Placebo (normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Interferon Alfa Followed by Filgrastim in Treating Patients With Gastrointestinal Tract Cancer
Status: COMPLETED
Conditions: Extrahepatic Bile Duct Cancer|Gastric Cancer|Gastrointestinal Carcinoid Tumor|Liver Cancer|Pancreatic Cancer|Small Intestine Cancer
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: recombinant interferon alfa|DRUG: fluorouracil|DRUG: hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Oleclumab (MEDI9447) Epidermal Growth Factor Receptor Mutant (EGFRm) Non-small Cell Lung Cancer (NSCLC) Novel Combination Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: BIOLOGICAL: Oleclumab|DRUG: Osimertinib|DRUG: AZD4635
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study for Evaluation of Immunogenicity and Reactogenicity of FluarixTM / Influsplit SSW® 2009/2010 in Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluarix™/Influsplit SSW®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cannabis For Cancer-Related Symptoms
Status: RECRUITING
Conditions: Pain|Nausea|Anxiety|Sleep Disturbance
Interventions: DRUG: Cannabis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RAD001 in Relapsed or Refractory AML, ALL, CML in Blastic-Phase, Agnogenic Myeloid Metaplasia, CLL, T-Cell Leukemia, or Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Leukemia|Mantle Cell Lymphoma|Myelofibrosis
Interventions: DRUG: RAD001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Evaluate Efficacy and Safety of AL002 in Participants With Early Alzheimer's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: AL002|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An fMRI Study Of Brain Response In Patients With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: Pregabalin, then placebo|DRUG: Placebo, then pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Oat Based Breakfast Cereals on Satiety and Food Intake
Status: COMPLETED
Conditions: Food Intake|Satiety
Interventions: OTHER: Test cereal 1, Oat-based|OTHER: Test Cereal 2, Oat based
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Differences in Efficacy Between Nasal and Oronasal Masks in the Treatment of OSA With CPAP
Status: COMPLETED
Conditions: Obstructive Sleep Apnea (OSA)
Interventions: DEVICE: Switch CPAP mask type
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Clinical Study to Evaluate the Efficacy of a Face Cream and Eye Cream
Status: COMPLETED
Conditions: Wrinkle|Photoaging|Fine Lines
Interventions: OTHER: Gentle Cleansing Lotion, Revision Skincare|OTHER: Aveeno Face Milk SPF 40+
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SGN-30 and Combination Chemotherapy in Treating Patients With Newly Diagnosed Anaplastic Large Cell Lymphoma
Status: TERMINATED
Conditions: Anaplastic Large Cell Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Doxorubicin hydrochloride|DRUG: vincristine sulfate|DRUG: prednisone|DRUG: SGN-30
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictors of Response to Augmentation With Ziprasidone (Geodon®) in Major Depressive Disorder
Status: COMPLETED
Conditions: Depression|Bipolar Disorder
Interventions: DRUG: ziprasidone|DRUG: Sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Project MIMIC (Maximizing Implementation of Motivational Incentives in Clinics)
Status: ACTIVE_NOT_RECRUITING
Conditions: Opioid-use Disorder
Interventions: BEHAVIORAL: Addiction Technology Transfer Center (ATTC) Training Strategy|BEHAVIORAL: Enhanced Addiction Technology Transfer Center (E-ATTC) Training Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Transradial Access for Ruptured Intracranial Aneurysms Embolization
Status: NOT_YET_RECRUITING
Conditions: Transradial Access
Interventions: PROCEDURE: transradial access|PROCEDURE: Transfemoral access
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dry-weight Probing Guided by Lung-Ultrasound on Ambulatory Blood Pressure and Arterial Stiffness in Hemodialysis Patients (LUST Sub-Study)
Status: COMPLETED
Conditions: Chronic Kidney Disease|Hemodialysis|Hypertension
Interventions: DEVICE: Extra-vascular lung water measurements by ultrasound|OTHER: Standard protocol of fluid management in hemodialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial on Skin Tags Approachment.
Status: COMPLETED
Conditions: Skin Tags
Interventions: PROCEDURE: Traditional method: Electrosurgery|PROCEDURE: Traditional method: Cryotherapy|PROCEDURE: Traditional method: Silver nitrate|PROCEDURE: Moist healing environment method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SPIRA™-A 3D and HCT/p DBM vs. Medtronic Divergent™-L/Perimeter™ and Recombinant BMP-2
Status: UNKNOWN
Conditions: Degenerative Disc Disease|Spinal Stenosis|Spondylolisthesis|Scoliosis
Interventions: DEVICE: ALIF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: BCX9930 for Treatment of PNH in Subjects With Inadequate Response to C5 Inhibitor Therapy
Status: TERMINATED
Conditions: Paroxysmal Nocturnal Hemoglobinuria (PNH)
Interventions: DRUG: BCX9930|DRUG: Eculizumab|DRUG: Ravulizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety Study of Tafenoquine
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Tafenoquine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Post-Surgical Stereotactic Radiotherapy (SRT) Versus GammaTile-ROADS (Radiation One and Done Study)
Status: RECRUITING
Conditions: Brain Metastases
Interventions: DEVICE: Gamma Tile-Surgically Targeted Radiation Therapy (STaRT)|RADIATION: Stereotactic Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Posterior CAD/CAM Cobalt-chromium Alloy Single Crowns: 4-year Prospective Clinical Study
Status: COMPLETED
Conditions: Single Tooth Lost
Interventions: DEVICE: Co-Cr single crown|OTHER: Periodontal parameters
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Colorectal Cancer
Status: WITHDRAWN
Conditions: Advanced Colorectal Cancer
Interventions: BIOLOGICAL: Activated CIK and CD3-MUC1 Bispecific Antibody in Treating colorectal cancer|PROCEDURE: Cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ferroptosis Study in SF3B1-mutant Myelodysplastic Syndromes (FerMDS)
Status: NOT_YET_RECRUITING
Conditions: Myelodysplastic Syndromes|Ferroptosis
Interventions: BIOLOGICAL: Biological sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Compare the Efficacy and Safety of DenosumAb Versus Placebo in Males With Osteoporosis
Status: COMPLETED
Conditions: Low Bone Mass|Low Bone Mineral Density|Males With Osteoporosis|Osteopenia|Osteoporosis
Interventions: DRUG: 60 mg denosumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Clinical Study of CD19 CAR NK Cells for the Treatment of Refractory Primary Immune Thrombocytopenia
Status: NOT_YET_RECRUITING
Conditions: Thrombocytopenia Alloimmune
Interventions: DRUG: anti-CD19 CAR NK cells (KN5501)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Randomized Open-label Study of Chidamide Plus HD-DEX Versus HD-DEX in ITP
Status: NOT_YET_RECRUITING
Conditions: Thrombocytopenia
Interventions: DRUG: Chidamide|DRUG: HD-DXM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Comparison of Wet Suction and Dry Suction Technique in EUS-FNA for the Outcomes in Pancreatic Solid Lesions
Status: COMPLETED
Conditions: Pancreatic Solid Lesions
Interventions: PROCEDURE: wet suction technique|PROCEDURE: dry suction technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Action Observation and Motor Imagery on Orofacial Sensorimotor Variables
Status: UNKNOWN
Conditions: Pain
Interventions: BEHAVIORAL: Moderate dosage training of action Observation and Motor imagery|BEHAVIORAL: Intensive dosage training of action observation and motor imagery|BIOLOGICAL: Intensive dosage orofacial exercises|BEHAVIORAL: Moderate dosage orofacial exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrative Study of Physiological Changes Induced by a 5-Day Dry Immersion on 20 Healthy Female Volunteers (DI5-Women)
Status: COMPLETED
Conditions: Weightlessness|Weightlessness; Adverse Effect
Interventions: OTHER: Dry immersion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Carbon Ion Re-Radiotherapy in Patients With Recurrent or Progressive Locally Advanced Head-and-Neck Cancer
Status: RECRUITING
Conditions: Locally Advanced Head-and-Neck Cancer
Interventions: RADIATION: C12 re-irradiation|RADIATION: Photon re-irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: α-Mangostin Hydrogel Film With Chitosan Alginate Base for Recurrent Aphthous Stomatitis (RAS)
Status: RECRUITING
Conditions: Recurrent Aphthous Stomatitis
Interventions: DRUG: α-Mangostin Hydrogel Film With Chitosan Alginate Base|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetic Study of RVX000222 in Healthy Subjects and Subjects With Low HDL Cholesterol
Status: COMPLETED
Conditions: Dyslipidemia|Atherosclerosis|Acute Coronary Syndrome|Cardiovascular Disease
Interventions: DRUG: RVX000222|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Local Infiltration of Tranexamic Acid and Lidocaine in Tonsillar Bed on Postoperative Bleeding and Pain During Tonsillectomy Surgery: Prospective, Randomized, Control Study
Status: COMPLETED
Conditions: Post Operative Pain|Postoperative Hemorrhage
Interventions: DRUG: lidocaine (2 %) 2 ml and tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Observational Study of Patients With HER2-Positive Metastatic or Locally Advanced Breast Cancer Treated With Herceptin (Trastuzumab) in 1st Line and Without Progression For 3 Years
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Evaluating the Safety and Efficacy of ENV-101 in Subjects With Idiopathic Pulmonary Fibrosis (IPF)
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: taladegib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Using KomPas+ in the Treatment of Patients With Intermittent Claudication
Status: UNKNOWN
Conditions: Intermittent Claudication|Peripheral Arterial Disease
Interventions: DEVICE: KomPas+|DEVICE: KomPas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Return to Work in Patients With Chronic Pain
Status: TERMINATED
Conditions: Chronic Pain|Endometriosis
Interventions: OTHER: Return To Work Coordination|BEHAVIORAL: Behaviour Change Ability Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment for Clostridium-difficile Infection With IMM529
Status: TERMINATED
Conditions: Clostridium Difficile Infection|Clostridium Difficile Infection Recurrence
Interventions: BIOLOGICAL: IMM-529|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate HLX10 Monotherapy for the Treatment of MSI-H or dMMR Solid Tumors That Failed to Respond to Standard Therapy
Status: RECRUITING
Conditions: MSI-H Solid Malignant Tumor
Interventions: DRUG: HLX10
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Versus High Dose Magnesium Sulfate in the Early Management of Rapid Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Magnesium Sulfate high dose|DRUG: Magnesium Sulfate low dose|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SCH 66336 With or Without Gemcitabine Followed by Surgery Compared With Surgery Alone in Treating Patients With Primary Liver Cancer
Status: WITHDRAWN
Conditions: Liver Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: lonafarnib|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of Alimta/Cisplatin/Gefitinib for Asian Non-smoking Participants With Non Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Gefitinib|DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noradrenaline, Acetylcholine and Dynamic Learning in Healthy Humans
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Reboxetine|DRUG: Rivastigmine|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: CKD-396 Drug-drug Interaction Study(A) (CKD-396 DDI(A) P1)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type II
Interventions: DRUG: Duvie Tab. 0.5mg|DRUG: Duvie Tab. 0.5mg + Januvia Tab. 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of KM257 in Patients With Advanced HER2-positive or Expressing Solid Tumors.
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumor
Interventions: BIOLOGICAL: KM257 Bispecific antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety, Tolerability, Reactogenicity, Immunogenicity of Baiya SARS-CoV-2 Vax 2 as a Booster for COVID-19
Status: NOT_YET_RECRUITING
Conditions: COVID-19 Vaccine|COVID-19
Interventions: BIOLOGICAL: 50 μg Baiya SARS-CoV-2 Vax 2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating the Interest of Vismodegib as Neo-adjuvant Treatment of Basal Cell Carcinoma (BCC)
Status: COMPLETED
Conditions: Basal Cell Carcinoma
Interventions: DRUG: ERIVEDGE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficiency of Combined Extracorporeal Blood Purification in Neurosurgical ICU. Prospective RCT
Status: UNKNOWN
Conditions: Septic Shock
Interventions: PROCEDURE: Combined extracorporeal blood purification|PROCEDURE: CRRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Outcome Parameters in Laser Rhytide Treatment
Status: COMPLETED
Conditions: Skin Aging
Interventions: PROCEDURE: Fractional carbon dioxide laser treatment|PROCEDURE: Fractional Er:YAG laser treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessment of Three Instruments for the Non-invasive Measurement of Arterial Stiffness.
Status: TERMINATED
Conditions: Healthy|Diabetes Type 2|Obesity|Coronary Artery Disease|Peripheral Arterial Disease
Interventions: DEVICE: ASI Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Bioequivalence Study of Torrent Pharmaceuticals Ltd.'s Fluoxetine Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Torrent's Fluoxetine Tablets|DRUG: Warner Chilcott LLC's Sarafem Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating TheSafety And Efficacy Of PF-05212377 Or Placebo In Subjects With Alzheimer's Disease With Existing Neuropsychiatric Symptoms On Donepezil
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: PF-05212377 (SAM-760)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lurbinectedin With Berzosertib, an ATR Kinase Inhibitor in Small Cell Cancers and High-Grade Neuroendocrine Cancers
Status: RECRUITING
Conditions: SCLC|Small Cell Cancer|Advanced Solid Tumor|High Grade Neuroendocrine Cancers
Interventions: DRUG: Lurbinectedin|DRUG: Berzosertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of SAR342434 to Humalog as the Rapid Acting Insulin in Adult Patients With Type 2 Diabetes Mellitus Also Using Insulin Glargine
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: SAR342434|DRUG: Humalog|DRUG: insulin glargine HOE901
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dextromethorphan, Gabapentin, and Oxycodone to Treat Opioid-Induced Hyperalgesia
Status: COMPLETED
Conditions: Hyperalgesia|Opioid-Related Disorders
Interventions: DRUG: Gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of Inactivated Vaccine for Prevention of SARS-CoV-2 Infection(COVID-19)
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Two doses of medium dosage inactivated SARS-CoV-2 vaccine at the schedule of day 0,28|BIOLOGICAL: Two doses of high dosage inactivated SARS-CoV-2 vaccine at the schedule of day 0,28|BIOLOGICAL: Two doses of placebo at the schedule of day 0,28|BIOLOGICAL: Two doses of low dosage inactivated SARS-CoV-2 vaccine at the schedule of day 0,28
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy
Status: UNKNOWN
Conditions: Chronic Periodontitis
Interventions: DEVICE: Antimicrobial photodynamic therapy (Periowave) and scaling and root planing|PROCEDURE: scaling and root planing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Recurrence of Crohn's Disease by Fecal Microbiota Therapy (FMT)
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: Fecal Microbiota Transplant (FMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 3 Study of OTO-104 in Subjects With Unilateral Meniere's Disease
Status: COMPLETED
Conditions: Meniere Disease
Interventions: DRUG: OTO-104|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MEDI9447 Alone and in Combination With MEDI4736 in Adult Participants With Select Advanced Solid Tumors.
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Oleclumab|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bypass Surgery and CD133 Marrow Cell Injection for Treatment of Ischemic Heart Failure
Status: COMPLETED
Conditions: Coronary Artery Disease With Need for Bypass Surgery|Myocardial Ischemia, Angina Pectoris|Congestive Heart Failure|Previous Myocardial Infarction
Interventions: PROCEDURE: Intramyocardial injection of autologous CD133+ marrow cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Sleep To Reduce Incident Depression Effectively
Status: ACTIVE_NOT_RECRUITING
Conditions: Insomnia, Primary|Major Depressive Disorder|Rumination
Interventions: BEHAVIORAL: digital Cognitive Behavioral Therapy for Insomnia|BEHAVIORAL: face-to-face Cognitive Behavioral Therapy for Insomnia|BEHAVIORAL: Sleep Hygiene Education Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal Metastases
Status: NOT_YET_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung|Brain Metastases|Leptomeningeal Metastasis
Interventions: DRUG: Lorlatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long-term, Open-label, Uncontrolled Trial of YM443 (Z-338) in Patients With Functional Dyspepsia
Status: COMPLETED
Conditions: Dyspepsia|Functional Dyspepsia
Interventions: DRUG: YM443
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare the Quadriceps Function of Adductor Canal Block Versus Femoral Nerve Block With Electromyography Following Total Knee Arthroplasty
Status: COMPLETED
Conditions: Quadriceps Function Monitored With Electromyography
Interventions: PROCEDURE: Nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Anosmia Rehabilitation in Patients Post Coronavirus Disease (COVID 19)
Status: WITHDRAWN
Conditions: Olfactory Disorder
Interventions: OTHER: Olfactory retraining|DRUG: corticosteroid nasal irrigation|OTHER: smell household Items|OTHER: Nasal Irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Natural History Study of Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL)
Status: RECRUITING
Conditions: Leukoencephalopathies|LBSL|Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation|White Matter Disease|Ataxia, Cerebellar|Genetic Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The MAMAACT Intervention
Status: COMPLETED
Conditions: Health Literacy|Stillbirth|Apgar; 0-3 at 1 Minute|Apgar; 4-7 at 1 Minute|Asphyxia
Interventions: BEHAVIORAL: MAMAACT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION