pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Radiosurgery Before Surgery for the Treatment of Brain Metastases
Status: RECRUITING
Conditions: Metastatic Malignant Neoplasm in the Brain|Metastatic Malignant Solid Neoplasm
Interventions: DRUG: Dexamethasone|PROCEDURE: Resection|RADIATION: Stereotactic Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aural Rehabilitation for Cochlear Implant Users Via Telerehab Technology
Status: COMPLETED
Conditions: Hearing Loss|Deafness
Interventions: BEHAVIORAL: Aural Rehabilitation Group|BEHAVIORAL: Cognitive Training Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase II Randomized Study Evaluating the Efficacy of Panitumumab (VEctibix ) and Trifluridine-Tipiracil (LOnsurf) in Pretreated RAS Wild Type Metastatic Colorectal Cancer Patients: the VELO Trial
Status: COMPLETED
Conditions: Metastatic Colon Cancer
Interventions: DRUG: Trifluridine Tipiracil|DRUG: Panitumumab 20 MG/1 ML Intravenous Solution [VECTIBIX]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benefit of Transradial Approach in Chronic Kidney Disease Population Undergoing Cardiac Catheterization
Status: RECRUITING
Conditions: Chronic Kidney Disease|Acute Kidney Injury|Heart Disease
Interventions: PROCEDURE: Cardiac Catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Dornase Alpha to Reduce Respiratory Failure After Severe Trauma
Status: RECRUITING
Conditions: Multiple Trauma|Respiratory Distress Syndrome, Adult
Interventions: DRUG: Dornase Alfa Inhalant Solution [Pulmozyme]|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ-77242113 for the Treatment of Participants With Generalized Pustular Psoriasis or Erythrodermic Psoriasis
Status: RECRUITING
Conditions: Generalized Pustular Psoriasis|Erythrodermic Psoriasis
Interventions: DRUG: JNJ-77242113
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NOX-E36 Multiple Ascending Dose Study in Healthy Volunteers and Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: NOX-E36|DRUG: NOX-E36
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CANABIC : CANnabis and Adolescents, a Brief Intervention (BI) to Reduce Their Consumption
Status: UNKNOWN
Conditions: Addictions|Adolescents|Primary Health Care|Brief Intervention
Interventions: BEHAVIORAL: Brief Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Targeting Brain Physiology to Treat Neuropsychiatric Symptoms of Dementia Using TMS-EEG and tDCS
Status: RECRUITING
Conditions: Alzheimer Disease|Dementia, Mixed|Dementia|Behavior Problem|Dementia, Alzheimer Type
Interventions: DEVICE: Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CJD (Creutzfeldt-Jakob Disease) Quinacrine Study
Status: COMPLETED
Conditions: Creutzfeldt-Jakob Disease
Interventions: DRUG: Quinacrine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatement of Extension Fractures of the Distal Radius
Status: COMPLETED
Conditions: Fracture of Distal Radius
Interventions: PROCEDURE: trans-styloid and intrafocal pinning on the one side|PROCEDURE: volar fixed-angle plating on the other side
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Efficacy Study of PRX-00023 in Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder (MDD)
Interventions: DRUG: PRX-00023|DRUG: Placebo for PRX-00023
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Trimodal Prehabilitation in Colorectal Cancer Patients
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: BEHAVIORAL: Exercise|DIETARY_SUPPLEMENT: Nutrition|BEHAVIORAL: Mindfulness
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Open-labelled Clinical Trial of Live Attenuated Varicella Vaccines to Evaluate the Immunity Persistence After Primary Immunization and Safety and Immunogenicity After the Booster Immunization
Status: COMPLETED
Conditions: Varicella
Interventions: BIOLOGICAL: Investigational live attenuated varicella vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prophylaxis Ephedrine or Ondansetron Prevents Hypotension After Spinal Anesthesia for Cesarean Section
Status: COMPLETED
Conditions: Anesthesia; Adverse Effect, Spinal and Epidural
Interventions: DRUG: Placebo|DRUG: Ondansetron|DRUG: Ephedrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Methodology Study To Examine 6-Week Food Intake With Liraglutide In Obese Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Liraglutide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Renal Mechanism of SGLT2 Inhibition
Status: RECRUITING
Conditions: Type 2 Diabetes|Diabetic Kidney Disease
Interventions: DRUG: canagliflozin|DRUG: Aminohippurate Sodium Inj 20%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PH94B in the Treatment of Adjustment Disorder With Anxiety
Status: COMPLETED
Conditions: Adjustment Disorder With Anxious Mood
Interventions: DRUG: PH94B|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Two Forms of Pentamidine in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
Status: COMPLETED
Conditions: Pneumonia, Pneumocystis Carinii|HIV Infections
Interventions: DRUG: Pentamidine isethionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study to Evaluate Different Formulations of GSK Biologicals' Influenza Vaccine GSK576389A
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: GlaxoSmithKline Biologicals' influenza vaccine GSK576389A|BIOLOGICAL: Fluarix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Promoting Prosocial Bystander Behavior in Intoxicated Men: Evaluation of RealConsent2.0
Status: RECRUITING
Conditions: Alcohol Intoxication|Sexual Violence|Helping Behavior
Interventions: BEHAVIORAL: RealConsent1.0|BEHAVIORAL: RealConsent2.0|BEHAVIORAL: Stress Management|BEHAVIORAL: Alcohol intoxication|BEHAVIORAL: No-Alcohol Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: JUS Media? Programme: A Food-Focused Media Literacy Intervention for Americanized Adolescents and Mothers Globally
Status: COMPLETED
Conditions: Nutrition Poor
Interventions: BEHAVIORAL: Workshop|BEHAVIORAL: SMS/Texting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Impact of Dexamethasone Added to Intra-articular Morphine and Bupivacaine for Post-operative Analgesia After Knee Arthroscopy
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: group M|DRUG: group MD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zinc Supplementation on Cellular Immunity in Thalassemia Major
Status: COMPLETED
Conditions: Thalassemia|Splenectomy; Status|Immunosuppression
Interventions: DRUG: Zinc Sulfate|DRUG: Sucrose Syrup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: GBV Prevention, Mitigation, and Response in Colombia
Status: ACTIVE_NOT_RECRUITING
Conditions: Refugee Self-reliance|Mental Health Issue|Empowerment|Gender Based Violence Knowledge and Perceived Risk|Decision Making
Interventions: BEHAVIORAL: Entrepreneurship School with Gender Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Prospective Randomized Double-Blind Trial Comparing 3 Doses of Intravenous Ketorolac for Pain Management
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: 10 mg of Ketorolac|DRUG: 15 mg of Ketorolac|DRUG: 30 mg of Ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Fate Modifications of Saturated Fats After an Overfeeding
Status: COMPLETED
Conditions: Obesity|Lipid Metabolism|Inflammation
Interventions: DIETARY_SUPPLEMENT: Hyperlipidic overfeeding
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Safety, PK, PD, and Efficacy of PRX-102 in Japanese Patients With Fabry Disease
Status: RECRUITING
Conditions: Fabry Disease
Interventions: DRUG: PRX-102 1 mg/kg every 2 weeks|DRUG: PRX-102 2 mg/kg every 4 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Vestibular Stimulation on Motor Function and Balance in Children With Hypotonic Cerebral Palsy
Status: UNKNOWN
Conditions: Hypotonic Cerebral Palsy
Interventions: OTHER: Conventional physiotherapy|OTHER: Vestibular stimulation with conventional physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Pioglitazone for Hematoma Resolution In Intracerebral Hemorrhage
Status: COMPLETED
Conditions: Intracerebral Hemorrhage
Interventions: DRUG: Pioglitazone|DRUG: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluid Distribution Timetable on Adherence to Fluid Restriction of Patients With End-Stage Renal Disease on Hemodialysis
Status: COMPLETED
Conditions: End-Stage Kidney Disease|Hemolysis|Nursing
Interventions: BEHAVIORAL: Fluid Distribution Timetable
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gabapentin, Methadone, and Oxycodone With or Without Venlafaxine Hydrochloride in Managing Pain in Participants With Stage II-IV Squamous Cell Head and Neck Cancer Undergoing Chemoradiation Therapy
Status: COMPLETED
Conditions: Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8|Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8
Interventions: DRUG: Gabapentin|DRUG: Methadone|DRUG: Oxycodone|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: Venlafaxine|DRUG: Venlafaxine Hydrochloride Extended Release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: mHealth Facilitated Intervention to Improve Medication Adherence Among Persons Living With HIV
Status: RECRUITING
Conditions: HIV|Medication Adherence|Telemedicine
Interventions: BEHAVIORAL: Face-to-Face ART Adherence Intervention|BEHAVIORAL: Carium Mobile Health Platform
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective, Multicenter Clinical Study of Prolonged-release Tacrolimus in Stable Pediatric Liver Transplant Recipients
Status: NOT_YET_RECRUITING
Conditions: Liver Transplant
Interventions: DRUG: Tacrolimus Sustained-release Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Paravertebral Block by Intraoperative Direct Access Versus Systemic Analgesia for Postthoracotomy Pain Relief
Status: COMPLETED
Conditions: Post Thoracotomy Pain
Interventions: COMBINATION_PRODUCT: Thoracic paravertebral block|DRUG: Systemic analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Innovative Drug Strategies in Improving Left Ventricular Function After Mitral Repair
Status: RECRUITING
Conditions: Congenital Mitral Insufficiency
Interventions: DRUG: Captopril Tablets|DRUG: Metoprolol Oral Tablet|DRUG: Spironolactone Tablets|DRUG: Torsemide Tablets|DRUG: Potassium citrate powder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Aizthromycin or Clarithromycin in H-pylori Eradication Regimen
Status: COMPLETED
Conditions: Peptic Ulcer|Dyspepsia|H-pylori
Interventions: DRUG: azithromycin|DRUG: clarithmycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acceptance and Commitment Therapy, a Mindfulness-Based Approach for Treatment of Chronic Musculoskeletal Pain
Status: COMPLETED
Conditions: Chronic Musculoskeletal Disease
Interventions: BEHAVIORAL: Acceptance and Committment Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Safety and Efficacy of REGN475(SAR164877) in Patients With Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: REGN475|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Research Study of Arsenic Trioxide (Trisenox) in Patients With Myelodysplastic Syndrome (MDS)
Status: TERMINATED
Conditions: Myelodysplastic Syndrome (MDS)
Interventions: DRUG: Arsenic Trioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Cetuximab and Combination Chemotherapy in Patients With Stage III-IV Resectable Oropharynx Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: cisplatin|DRUG: docetaxel|DRUG: fluorouracil|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CAFE Comparison of Atypicals in First Episode of Psychosis
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders|Mental Health|Mental Disorders
Interventions: DRUG: Olanzapine, risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between Early Vitrectomy and Observation for Spontaneous Closure of Traumatic Macular Hole
Status: COMPLETED
Conditions: Trauma|Macular Hole
Interventions: PROCEDURE: vitrectomy surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Patients With Stage IV Lung Cancer
Status: TERMINATED
Conditions: Stage IV Lung Cancer
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Nivolumab Intravenous (IV) to Subcutaneous (SC) Switch in Adjuvant Melanoma and Bladder Cancer
Status: WITHDRAWN
Conditions: Melanoma|Urothelial Carcinoma
Interventions: DRUG: Nivolumab/rHuPH20|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of COVID-19 on Mental Health of Patients With Skin Picking
Status: COMPLETED
Conditions: Skin Picking
Interventions: BEHAVIORAL: Internet-based Cognitive Behavioral Therapy|OTHER: Quality of life promotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Relief of Tooth Sensitivity of an Experimental Mouthrinse Device
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: DEVICE: Mouthwash|DRUG: Potassium nitrate toothpaste|DRUG: Sodium fluoride toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of an E-health Educational Intervention for Cardiovascular Disease Adults in Improving Outcomes
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: BEHAVIORAL: e-health educational intervention (eHEI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigate Bioequivalence of Alpelisib Granule and Film-coated Tablet Formulation and the Food Effect of Alpelisib Granule Formulation in Adult Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Treatment A|DRUG: Treatment B|DRUG: Treatment C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Discontinuation of Postmenopausal Hormone Therapy: Impact on the Cardiovascular System and Quality of Life
Status: UNKNOWN
Conditions: Menopause|Atherosclerosis|Cardiovascular Diseases|Estrogen Replacement Therapy
Interventions: DRUG: Estradiol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Intravenous ATYR1923 (Efzofitimod) for Pulmonary Sarcoidosis
Status: COMPLETED
Conditions: Pulmonary Sarcoidosis
Interventions: BIOLOGICAL: Efzofitimod 1.0 mg/kg or Placebo|BIOLOGICAL: Efzofitimod 3.0 mg/kg or Placebo|BIOLOGICAL: Efzofitimod 5.0 mg/kg or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glycemic Impact of Myo-inositol in Pregnancy
Status: UNKNOWN
Conditions: Gestational Diabetes Mellitus as Antepartum Condition
Interventions: DIETARY_SUPPLEMENT: myo-inositol|DEVICE: Continuous glucose monitoring surveillance|DEVICE: Glucose monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Molecular-Functional Imaging of Hypoxia in Childhood Sarcomas
Status: ENROLLING_BY_INVITATION
Conditions: Rhabdomyosarcoma|Non-Rhabdo. Soft Tissue Sarcoma
Interventions: DRUG: 18F-FAZA (F18-Fluoroazomycin Arabinoside)|DIAGNOSTIC_TEST: Blood Oxygen Level Dependent [BOLD] MRI|DIAGNOSTIC_TEST: Diffusion-Weighted [DW] MRI|DIAGNOSTIC_TEST: Magnetic Resonance Spectroscopy [MRS]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pilot Study to Evaluate Immunopotentiating Effects of Immulina in Elderly Individuals
Status: COMPLETED
Conditions: Elderly Immune Senescence
Interventions: DIETARY_SUPPLEMENT: Immulina
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cardiac Allograft Remodeling and Effects of Sirolimus
Status: TERMINATED
Conditions: Cardiac Hypertrophy|Immunosuppression
Interventions: RADIATION: Cardiac MRI|PROCEDURE: Coronary angiography with IVUS|OTHER: Cardiac Allograft Remodeling|DRUG: M-TOR Immunosuppression|PROCEDURE: Cardiac Biopsy C4D stain|GENETIC: Genetic Mechanism of M-TOR|OTHER: Cardiopulmonary Exercise Test (CPET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closed Suction Drain vs no Drain on Symptomatic Seroma Formation After Laparoscopic Inguinal Hernia Repair
Status: COMPLETED
Conditions: Inguinal Hernia Without Obstruction or Gangrene
Interventions: PROCEDURE: Laparoscopic Inguinal Hernia (TEP/TAPP) Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy Combined With Bevacizumab vs Bevacizumab Alone for Neovascular Age-Related Macular Degeneration
Status: UNKNOWN
Conditions: Neovascular Age-Related Macular Degeneration
Interventions: DRUG: Bevacizumab (Avastin), Verteporfin (Visudyne)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess the Utility of the Point Mini in a Clinical Take-home Study
Status: NOT_YET_RECRUITING
Conditions: Amputation; Traumatic, Hand|Amputation, Congenital
Interventions: DEVICE: Point Mini
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plerixafor Plus Granulocyte Colony-Stimulating Factor For Mobilization And Collection Of Peripheral Hematopoietic Stem Cells In Japanese Participants With Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: plerixafor GZ316455|DRUG: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Elastography Changes in Cesarean Scar After Negative Pulsed Pressure Treatment
Status: NOT_YET_RECRUITING
Conditions: Cesarean Scar|Elastography
Interventions: DEVICE: negative pulsed pressure AeroFlow system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Imatinib Mesylate to Treat Nephrogenic Systemic Fibrosis
Status: COMPLETED
Conditions: Nephrogenic Systemic Fibrosis
Interventions: DRUG: Imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yttrium Y 90 Ibritumomab Tiuxetan, Fludarabine, Radiation Therapy, and Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: B-cell Chronic Lymphocytic Leukemia|Nodal Marginal Zone B-cell Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Splenic Marginal Zone Lymphoma|Waldenström Macroglobulinemia
Interventions: BIOLOGICAL: rituximab|DRUG: cyclosporine|DRUG: fludarabine phosphate|DRUG: mycophenolate mofetil|RADIATION: yttrium Y 90 ibritumomab tiuxetan|PROCEDURE: peripheral blood stem cell transplantation|PROCEDURE: allogeneic hematopoietic stem cell transplantation|RADIATION: total-body irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Intensity Conditioning for Umbilical Cord Blood Transplant in Pediatric Patients With Non-Malignant Disorders
Status: COMPLETED
Conditions: Non Malignant Disorders|Immunodeficiencies|Congenital Marrow Failures|Hemoglobinopathies|Inborn Errors of Metabolism|Sickle Cell|Thalassemia|Lysosomal Storage Disease
Interventions: BIOLOGICAL: Unrelated Umbilical Cord Blood Transplant|DRUG: Reduced Intensity Conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventive Effect of Pitavastatin on Contrast-Induced Nephropathy in Patients With Renal Dysfunction
Status: UNKNOWN
Conditions: Contrast-induced Nephropathy
Interventions: DRUG: Pitavastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mind and Body Approaches to Pain Reduction in Youth With Migraine
Status: RECRUITING
Conditions: Headache, Migraine|Migraine|Migraine Disorders|Headache
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy (CBT)|DRUG: Placebo|DRUG: Amitriptyline|BEHAVIORAL: Biofeedback-Assisted Relaxation Training (BART)|BEHAVIORAL: Cognitive Reappraisal Training (CR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: ACT Combined Yoga for Parental Burnout in Parents With Autistic Children
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Acceptance commitment therapy and yoga|BEHAVIORAL: Active Comparator: Mental Health Education Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Listening to Lullabies and Self-selected Music on Distress and Maternal Attachment in Pregnant Women
Status: COMPLETED
Conditions: Psychological Distress|Bonding
Interventions: OTHER: listening to music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of AK112 in Patients With Unresectable Hepatocellular Carcinoma (HCC)
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: AK112
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men to Test How Different Doses of BI 1815368 Are Tolerated and How BI 1815368 is Taken up in the Body With or Without Food
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1815368 formulation 1|DRUG: Placebo|DRUG: BI 1815368 formulation 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Restless Legs Patient Study On Absorption, Distribution, Metabolism And Excretion Of Ropinirole And The Effect Of Food
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: Ropinirole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Advantages and Disadvantages of Long Term Sedation in Intensive Care Unit Patients
Status: COMPLETED
Conditions: Critical Illness|Length of Stay|Respiration, Artificial|Intensive Care Units
Interventions: PROCEDURE: Sedation or no sedation during mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Sildenafil Citrate in Patients With Unexplained Recurrent Miscarriages
Status: UNKNOWN
Conditions: Recurrent Miscarriage
Interventions: DRUG: Sildenafil citrate|DRUG: matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality in Reducing Pain and Anxiety in Cancer Participants Undergoing Painful Procedures
Status: RECRUITING
Conditions: Malignant Neoplasm
Interventions: OTHER: Best Practice|OTHER: Laboratory Biomarker Analysis|DEVICE: Oculus Rift Headset|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gemcitabine-Cisplatin-90Y TARE for Unresectable Intrahepatic Cholangiocarcinoma
Status: TERMINATED
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DEVICE: SIR-Spheres microspheres (Yttrium-90 Microspheres)|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study to Evaluate IGSC 20% Biweekly Dosing in Treatment-Experienced Participants and Loading/Maintenance Dosing in Treatment-Naïve Participants With Primary Immunodeficiency
Status: COMPLETED
Conditions: Primary Immunodeficiency
Interventions: BIOLOGICAL: IGSC 20%
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Central Venous Catheter Insertion Site and Colonization in Pediatric Cardiac Surgery
Status: WITHDRAWN
Conditions: Central Line-associated Bloodstream Infection (CLABSI)|Central Venous Catheter Associated Bloodstream Infection|Heart; Surgery, Heart, Functional Disturbance as Result|Congenital Heart Disease|Newborn; Infection
Interventions: PROCEDURE: Internal jugular vein CVC insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Fecal Microbiota Therapy in Steroid Ineligible Alcoholic Hepatitis
Status: UNKNOWN
Conditions: Alcoholic Hepatitis
Interventions: OTHER: Fecal Transplantation|DRUG: Standard Medical Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled NO for the Treatment of COVID-19 Caused by SARS-CoV-2 (US Trial)
Status: TERMINATED
Conditions: Corona Virus Infection|COVID-19|SARS-CoV 2|Nitric Oxide|Respiratory Disease|Pneumonia, Viral|Inhaled Nitric Oxide
Interventions: DEVICE: Nitric Oxide delivered via LungFit™ system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Study of Cytochrome P450 Polymorphisms (CYP2D6, CYP3A4/5 and CYP2C19) in Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Neoplasms|Survival Analysis|Antineoplastic Agents|Therapeutic Uses
Interventions: DRUG: tamoxifen
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Compare Ocular Safety and Tolerability of Prednisolone Acetate 0.5% Eye Drops Versus Vehicle in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Prednisolone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Hybrid Molecular Imaging of ER in Breast Cancer Patients With DCIS
Status: COMPLETED
Conditions: Breast Cancer|Ductal Carcinoma in Situ - Category
Interventions: DRUG: (18F)FES|DRUG: Gadobenate dimeglumine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Child Development and Primary Care in Low Income Families
Status: ACTIVE_NOT_RECRUITING
Conditions: Parenting|Development, Child
Interventions: BEHAVIORAL: Sit Down and Play|OTHER: Child Safety Handout
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ESTOCMA: Mental Health Application for Enhancing Mental Health Literacy About Obsessive-compulsive Disorder
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: Use of a mobile health application until app completion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Reducing the Negative Effects of Surgical Conditions Use of Double Layer Mask Against Electrocautery With Smoke Filter
Status: COMPLETED
Conditions: Surgical Procedure, Unspecified
Interventions: DEVICE: smoke filtering electrocautery device|OTHER: double mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Acute Exposure of High Altitude on Cognitive Function
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: OTHER: Low altitude: 470m above sea level|OTHER: Säntis; 2500m above sea Level
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Measurement of the Effect of Gingko Biloba Extract on Ocular and Nailfold Blood-flow in NTG
Status: UNKNOWN
Conditions: Normal Tension Glaucoma
Interventions: DIETARY_SUPPLEMENT: Gingko Baloba|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of CBL0137 in Combination With Ipilimumab and Nivolumab Therapy in Melanoma
Status: SUSPENDED
Conditions: Locally Advanced or Metastatic Melanoma
Interventions: DRUG: CBL0137|DRUG: Ipilimumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Randomized Trial of Carboplatin+Pemetrexed+Bevacizumab+/- Atezolizumab in Stage IV NSCLC
Status: RECRUITING
Conditions: Non-Small Cell Carcinoma of Lung, TNM Stage 4
Interventions: DRUG: Arm A|DRUG: Arm B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy With Interferon Plus Interleukin 2 and Hepatitis B Vaccine in Chronic Hepatitis B Patients
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Entecavir|DRUG: Interferon alfa-2b|DRUG: Interleukin 2|DRUG: Hepatitis B Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AneuFix - Prophylactic Sac Filling
Status: RECRUITING
Conditions: Abdominal Aortic Aneurysm|Endoleak
Interventions: DEVICE: Prophylactic sac filling with AneuFix
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Synbiotic as an Adjunct to Mechanical Treatment of Gingivitis
Status: COMPLETED
Conditions: Gingivitis; Chronic|Smoking
Interventions: DRUG: Synbiotic Supplement|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influenza Vaccination During Coronavirus Disease 2019 Outbreak After Acute Coronary Syndrome and Chronic Heart Failure
Status: UNKNOWN
Conditions: Acute Coronary Syndrome|Chronic Heart Failure
Interventions: BIOLOGICAL: Ultrix Quadri
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Pilot RCT to Improve Cognitive Processing Speed in Acute SCI
Status: RECRUITING
Conditions: Spinal Cord Injuries|Cognitive Dysfunction|Cognitive Impairment|Acute Spinal Cord Injury
Interventions: BEHAVIORAL: game-like computerized activities|BEHAVIORAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Stopping Thromboprophylaxis Based on Ultrasound Results After Total Knee Replacement
Status: COMPLETED
Conditions: Thromboembolism|Arthroplasty Replacement, Knee
Interventions: PROCEDURE: Bilateral ultrasound examination 7+/- 2 after surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Breaking Bad News in Obstetrics: A Trial of Simulation-Debrief Based Education
Status: COMPLETED
Conditions: Breaking Bad News Skills|Communications Skills|Medical Education|Obstetrics|Simulation
Interventions: BEHAVIORAL: Simulation-Debrief|BEHAVIORAL: Traditional lecture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: NRF for Improved Re-Entry Outcomes for Offenders With Brain Injury (Brain Injury RE)
Status: RECRUITING
Conditions: Brain Injury
Interventions: BEHAVIORAL: NeuroResource Facilitation (NRF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Incentive Spirometry Added to Physiotherapy to Reduce Postoperative Pulmonary Complications After Lung Surgery
Status: COMPLETED
Conditions: Lung Neoplasms|Benign Lung Disease
Interventions: PROCEDURE: Incentive spirometry|OTHER: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Standard Versus Intensity-Modulated Pelvic Radiation Therapy in Treating Patients With Endometrial or Cervical Cancer
Status: COMPLETED
Conditions: Cervical Cancer|Endometrial Cancer|Gastrointestinal Complications|Perioperative/Postoperative Complications|Radiation Toxicity|Urinary Complications|Urinary Tract Toxicity
Interventions: RADIATION: Standard radiation therapy|RADIATION: intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Limbus-derived Stem Cells for Prevention of Postoperative Corneal Haze
Status: UNKNOWN
Conditions: Corneal Scars and Opacities
Interventions: BIOLOGICAL: Stem cells|OTHER: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Shoulder Retraction on Success Rate of Subclavian Vein Catheterization
Status: COMPLETED
Conditions: Subclavian Vein Catheterization
Interventions: PROCEDURE: position of shoulder retraction|PROCEDURE: position of neutral shoulder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: EEG Predictors of Neuropathic Pain in SCI
Status: UNKNOWN
Conditions: Central Neuropathic Pain|Spinal Cord Injuries
Interventions: DIAGNOSTIC_TEST: EEG recording 1|DIAGNOSTIC_TEST: EEG recording 2|DIAGNOSTIC_TEST: Sensory Test|DIAGNOSTIC_TEST: Brief Pain Inventory 1|DIAGNOSTIC_TEST: Multidimensional health locus of control|DIAGNOSTIC_TEST: Sensory test thermal|DIAGNOSTIC_TEST: Neuropathic pain symptoms|DIAGNOSTIC_TEST: McGill pain questionnaire|DIAGNOSTIC_TEST: Pain Catastrophising Scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Photodynamic Therapy for Lentigo Maligna Using 5-aminolevulinic Acid Nanoemulsion as a Light Sensitizing Cream
Status: COMPLETED
Conditions: Lentigo Maligna
Interventions: DRUG: 5-aminolevulinic acid nanoemulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MR Guided Focused Ultrasound (FUS) for the Treatment of Trigeminal Neuralgia
Status: RECRUITING
Conditions: Trigeminal Neuralgia
Interventions: DEVICE: ExAblate Transcranial treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Work Package 3 Education for ICU Clinicians in Basic Palliative Care
Status: NOT_YET_RECRUITING
Conditions: ICU|Staff Attitude|Learning|Palliative Care, Patient Care
Interventions: BEHAVIORAL: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sirolimus and Durvalumab for the Treatment of Stage I-IIIA Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Non-Small Cell Carcinoma|Stage I Lung Cancer AJCC v8|Stage IA1 Lung Cancer AJCC v8|Stage IA2 Lung Cancer AJCC v8|Stage IA3 Lung Cancer AJCC v8|Stage IB Lung Cancer AJCC v8|Stage II Lung Cancer AJCC v8|Stage IIA Lung Cancer AJCC v8|Stage IIB Lung Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8
Interventions: DRUG: Durvalumab|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Antirheumatic Treatment on Levels of Survivin in Rheumatoid Arthritis Patients
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: methotrexate|DRUG: sulfasalazine|DRUG: abatacept|DRUG: tocilizumab|DRUG: tofacitinib/baricitinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Single Arm Clinical Study Evaluating the Safety, Tolerability, and Efficacy of Multiple Intravenous Administration of TP03HN106 in Patients With Critical Limb Ischemia
Status: NOT_YET_RECRUITING
Conditions: Critical Limb Ischemia
Interventions: DRUG: TP03HN106
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cooled Radiofrequency Ablation vs. Thermal Radiofrequency Ablation
Status: COMPLETED
Conditions: Chronic Thoracic Back Pain
Interventions: PROCEDURE: c-RFA|PROCEDURE: tRFA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of a Portable Artificial Pancreas System in Type 1 Diabetes Mellitus (T1DM) - Padova
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Portable artificial pancreas system with Control-To-Range
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial Comparing Residual Kidney Function in Patients Undergoing Three or Four Exchanges CAPD
Status: COMPLETED
Conditions: End Stage Renal Disease|Anuria|Peritonitis
Interventions: OTHER: Three 2-liter exchanges daily CAPD|OTHER: Four 2-liter exchanges daily CAPD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sensation After Nipple Sparing Mastectomy and Breast Reconstruction With or Without Neurotized Free Tissue Transfer
Status: WITHDRAWN
Conditions: Mastectomy|Breast Reconstruction
Interventions: PROCEDURE: Breast Reconstruction with Artificial Implant|PROCEDURE: Autologous Breast Reconstruction|PROCEDURE: Neurotization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of FOR-Care Model on Preventive Medicine
Status: RECRUITING
Conditions: Diabetes Mellitus|Body Weight|Family Medicine|Hypertension|Preventive Medicine
Interventions: DIAGNOSTIC_TEST: Height, Weight, and Blood Pressure Measurement Procedures Improvement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of a Natural Ingredient on Obesity
Status: COMPLETED
Conditions: Overweight and Obesity|High Blood Pressure
Interventions: DIETARY_SUPPLEMENT: dietary supplement consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study To Evaluate The Pharmacokinetic Interaction Between PLA-695 And Methotrexate In Adults With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: PLA-695
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extension of Study Fx-005 Evaluating Long-Term Safety And Clinical Outcomes Of Fx-1006A In Patients With Transthyretin Amyloid Polyneuropathy
Status: COMPLETED
Conditions: Familial Amyloid Polyneuropathy|ATTR-PN
Interventions: DRUG: Fx-1006A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Ischemic Conditioning in Acute Ischemic Cerebral Vascular Disease Patients With Coexistence of Cerebral and Coronary Atherosclerosis（RIC-CCCA）
Status: ENROLLING_BY_INVITATION
Conditions: Acute Ischemic Cerebral Vascular Disease
Interventions: DEVICE: RIC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION