pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Ligation of Intersphincteric Fistula Tract (LIFT) Versus LIFT-plug Procedure for Anal Fistula Repair
Status: UNKNOWN
Conditions: Anorectal Fistula|Extracellular Matrix Alteration
Interventions: PROCEDURE: LIFT-plug|PROCEDURE: LIFT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Stem Cell Transplantation Followed By Targeted Immune Therapy In Average Risk Leukemia
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Myelodysplastic Syndrome|Juvenile Myelomonocytic Leukemia
Interventions: DRUG: Fludarabine|DRUG: Busulfan|DRUG: GVHD Prophylaxis|DRUG: Gemtuzumab Ozogamicin|DRUG: Anti-Thymocyte Globulin|DRUG: Isotretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of rTMS for Cognitive Deficits in Chronic Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DEVICE: repetitive TMS|DEVICE: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Chlorophyllin Tablets for Urinary Bleeding Following Radiation Therapy for Cancers of Pelvic Organs
Status: UNKNOWN
Conditions: Hemorrhagic Cystitis
Interventions: DRUG: Sodium Copper Chlorophyllin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aspirin for Prevention of Venous Thromboembolism Among Ovarian Cancer Patients Receiving Neoadjuvant Chemotherapy
Status: COMPLETED
Conditions: Venous Thromboembolism|Ovarian Cancer
Interventions: DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Participants With HR+/HER2- Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Sacituzumab Govitecan-hziy|DRUG: Eribulin|DRUG: Capecitabine|DRUG: Gemcitabine|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictive Value of FDG-PET-CT Scans for Patients With Lung Cancer Receiving Concurrent Chemo-Radiation
Status: TERMINATED
Conditions: Lung Cancer|SCLC|NSCLC
Interventions: OTHER: 18F-deoxyglucose (FDG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Unrelated Donor Transplant for Malignant and Non-Malignant Disorders
Status: TERMINATED
Conditions: Leukemia|Lymphoma|Bone Marrow Failure Syndromes|Immunodeficiencies|Histiocytosis
Interventions: PROCEDURE: UDAlloSCT|OTHER: Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Rediscovery for Rare Immune Mediated Inflammatory Diseases
Status: RECRUITING
Conditions: Behcet's Disease|Idiopathic Inflammatory Myopathies|IgG4-related Disease
Interventions: DRUG: Filgotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ-40346527 in Patients With Active Rheumatoid Arthritis Despite Disease-modifying Antirheumatic Drug Therapy
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: JNJ-40346527|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness in Daily Practice of Different Treatment Strategies for Early Rheumatoid Arthritis.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Methotrexate|DRUG: Sulfasalazine|DRUG: Leflunomide|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EoE(Eosinophilic Esophagitis)
Status: COMPLETED
Conditions: Eosinophilic Esophagitis|Dysphagia
Interventions: PROCEDURE: Eosinophilic Esophagitis with Dysphagia|PROCEDURE: Eosinophilic Esophagitis with Dysphagia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination of Bevacizumab, Pertuzumab, and Sandostatin for Adv. Neuroendocrine Cancers
Status: COMPLETED
Conditions: Neuroendocrine Carcinoma
Interventions: DRUG: Bevacizumab|DRUG: Pertuzumab|DRUG: Sandostatin LAR® Depot
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness and Safety of 4% Sodium Citrate as a Lock Solution in Central Venous Hemodialysis Catheter
Status: UNKNOWN
Conditions: Central Venous Catheter Thrombosis|Renal Dialysis
Interventions: DRUG: 4% sodium citrate|DRUG: heparin group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Flavopiridol in Treating Patients With Recurrent Intermediate-Grade or High-Grade Non-Hodgkin's Lymphoma or Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: alvocidib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Sequelae of Mastectomy and Quadrantectomy Respect to the Reaching Movement in Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer|Pain, Chronic|Pain, Postoperative|Mastectomy; Lymphedema
Interventions: OTHER: Rehabilitation protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Limb Remote Ischemic Preconditioning Reduces Heart and Lung Injury After Abdominal Aortic Aneurysm Repair
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: PROCEDURE: Limb remote ischemic preconditioning(LRIP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics of Oral Treprostinil in Patients With Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis
Interventions: DRUG: treprostinil diethanolamine|DRUG: treprostinil diethanolamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Bariatric Surgery Patients Before and After Sleeve Gastrectomy in Terms of Nutritional Status
Status: COMPLETED
Conditions: Obesity|Bariatric Surgery Candidate|Healthy Eating Index
Interventions: PROCEDURE: Pre-operative LSG patients|PROCEDURE: Post-operative patients 1st month|PROCEDURE: Post-operative patients 3rd month|PROCEDURE: Post-operative patients 6th month
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adaptation of the STEPPING ON Fall Prevention Program for Older Adults Receiving Cancer Therapy
Status: COMPLETED
Conditions: Geriatric Disorder|Cancer|Patient Fall
Interventions: OTHER: Stepping On Education Program|OTHER: Home visit|OTHER: Patient Questionnaire|OTHER: Mini-Balance Evaluation Systems Test|OTHER: GAITRite|OTHER: Precise measure of movement testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Paracetamol AfteR Traumatic Brain InjurY Study
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: DRUG: Paracetamol|DRUG: 0.9% Sodium Chloride Schedule:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan and Paclitaxel in Treating Patients With Metastatic or Recurrent Cancer
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: irinotecan hydrochloride|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Panobinostat (LBH589): Acute Graft Versus Host Disease (aGVHD) Prevention
Status: COMPLETED
Conditions: Graft Versus Host Disease|GVHD
Interventions: DRUG: Panobinostat|DRUG: Sirolimus|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Darbepoetin Alpha in Myelodysplastic Syndromes (MDS)
Status: UNKNOWN
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Darbepoetin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Oxytocin and Lorazepam on Fear-related Intra-amygdalar Activity
Status: COMPLETED
Conditions: Oxytocin, Lorazepam, Anti-Anxiety Agents, Physiological Effects of Drugs
Interventions: DRUG: Oxytocin|DRUG: Lorazepam 1 mg|DRUG: Placebo nasalspray|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bioequivalence Study of Cetirizine Hydrochloride 10mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cetirizine Hydrochloride 10 mg tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: LoW Dose-Intensity vs. Standard Dose-Intensity COntinuous Renal ReplaceMent Therapy in Critically Ill Patients (WISDOM)
Status: NOT_YET_RECRUITING
Conditions: Acute Kidney Injury|Dialysis; Complications
Interventions: DEVICE: Continuous Renal Replacement Therapy (CRRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Dried Human Amnion Graft to Improve Postprostatectomy Incontinence and Potency
Status: NOT_YET_RECRUITING
Conditions: Continence|Potency|Complication|Biochemical Recurrence
Interventions: DRUG: dHAM|DRUG: No dHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Routine Versus As-Needed Stress Testing in Asymptomatic Patients With High-Risk Coronary Calcium
Status: NOT_YET_RECRUITING
Conditions: Coronary Atherosclerosis Due to Calcified Coronary Lesion
Interventions: DIAGNOSTIC_TEST: Non-invasive stress test|DIAGNOSTIC_TEST: Medical treatment without further testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Laser Assisted Epidermal to Intradermal Administration of Seasonal Influenza Vaccine
Status: COMPLETED
Conditions: Influenza in Human
Interventions: BIOLOGICAL: seasonal influenza vaccine|DEVICE: fractional Er:Yag laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Development, Field Testing and Evaluation of the Efficacy of a Hand-held, Portable and Affordable Thermo-coagulator to Prevent Cervical Cancer in Low- and Middle-income Countries
Status: COMPLETED
Conditions: Cervical Precancer
Interventions: PROCEDURE: Thermocoagulation (device)|PROCEDURE: Cryotherapy (device)|PROCEDURE: LEEP (device)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Epidural Bupivacain-soaked Absorbable Gelatin Sponge on Post-operative Pain in Lumbar Laminectomy
Status: WITHDRAWN
Conditions: Lumbar Laminectomy
Interventions: DRUG: bupivacaine|OTHER: saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Assess the Safety, Tolerability and Pharmacokinetics of ACH-000029 in Healthy Subjects
Status: TERMINATED
Conditions: Healthy Volunteers
Interventions: DRUG: ACH-000029|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase Ⅱ Dose Response Study of NPO-13 in Patients Undergoing Total Colonoscopy
Status: COMPLETED
Conditions: Bowel Disease
Interventions: DRUG: NPO-13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Usefulness of a Treat and Extend Regimen Using Ranibizumab for Neovascular AMD.
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: Intraviteal Ranibizumab 0.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo-controlled Study Comparing Niraparib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab as Maintenance Therapy in Participants With Advanced/Metastatic Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer, Non-Small Cell
Interventions: DRUG: Niraparib|DRUG: Pembrolizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid Tumors
Status: RECRUITING
Conditions: Cutaneous Melanoma|Non-small Cell Lung Cancer|Colorectal Neoplasms|Pancreatic Neoplasms|Mesothelioma
Interventions: DRUG: PF-08046049
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Fluticasone Furoate/Vilanterol/Umeclidinium Compared With Vilanterol/Umeclidinium in Reducing Air Trapping and Airway and Blood Cytokine Levels in COPD
Status: NOT_YET_RECRUITING
Conditions: COPD
Interventions: DRUG: Trelegy or Anoro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FDM for Subacute and Chronic Extremity Pain in the ED
Status: TERMINATED
Conditions: Myofascial Pain|Chronic Pain|Extremities Disorders|Osteopathic Manipulation
Interventions: PROCEDURE: Fascial Distortion Model (FDM)|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Suboccipitalis Myofascial Release in Hamstring Tightness in Patients With Anterolisthesis
Status: TERMINATED
Conditions: Anterolisthesis
Interventions: OTHER: Suboccipital myofascial release|OTHER: Conventional Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating Three Fixed Dosages of Paliperidone Extended-Release (ER) Tablets and Olanzapine in the Treatment of Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Paliperidone ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Trial to Study the Effect of CVL-231 on 24-Hour Ambulatory Blood Pressure in Participants With Schizophrenia
Status: COMPLETED
Conditions: Blood Pressure|Schizophrenia
Interventions: DRUG: CVL-231
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Transcutaneous Electrical Nerve Stimulation (TENS) in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DEVICE: Transcutaneous electrical nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Effects of Betaine Supplementation
Status: COMPLETED
Conditions: Obesity|Dysglycemia
Interventions: DRUG: Betaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: STI571 ProspectIve RandomIzed Trial: SPIRIT
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Imatinib mesylate 400 mg|DRUG: Imatinib mesylate 600 mg|DRUG: Imatinib 400 mg + Peg-Interferon|DRUG: Imatinib mesylate 400 mg + Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRC-063 in an ADULT Workplace Environment
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: DRUG: PRC-063 25 mg|DRUG: Placebo|DRUG: PRC-063 35 mg|DRUG: PRC-063 45 mg|DRUG: PRC-063 55 mg|DRUG: PRC-063 70 mg|DRUG: PRC-063 85 mg|DRUG: PRC-063 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant FOLFOXIRI Chemotherapy in Resectable Liver Metastasis of Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Neoplasms|Drug Therapy
Interventions: DRUG: FOLFOXIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Application of Fibroblast Activation Protein PET/MRI in Liver Fibrosis
Status: RECRUITING
Conditions: Liver Fibrosis|Positron Emission Tomography|Magnetic Resonance Imaging
Interventions: DEVICE: PET/MR|DEVICE: PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: TAS-102 With Concurrent Radiation for the Treatment of Untreated Resectable Stage II-III Rectal Cancer
Status: RECRUITING
Conditions: Rectal Adenocarcinoma|Stage IIA Rectal Cancer AJCC v8|Stage IIB Rectal Cancer AJCC v8|Stage III Rectal Cancer AJCC v8|Stage IIIA Rectal Cancer AJCC v8|Stage IIIB Rectal Cancer AJCC v8|Stage IIIC Rectal Cancer AJCC v8
Interventions: RADIATION: 3-Dimensional Conformal Radiation Therapy|RADIATION: Intensity-Modulated Radiation Therapy|DRUG: Trifluridine and Tipiracil Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Cemiplimab Anti-programmed Death-ligand 1 (Anti-PD-1) and Other Agents in Japanese Adult Patients With Advanced Malignancies
Status: RECRUITING
Conditions: Advanced Malignancies
Interventions: DRUG: Cemiplimab|DRUG: Ipilimumab|DRUG: Platinum-doublet chemotherapy|DRUG: Gemcitabine|DRUG: Pemetrexed|DRUG: Paclitaxel|DRUG: Fianlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Drug-eluting Stent (DES) In-Stent Restenosis With SeQuent® Please Paclitaxel Eluting Percutaneous Transluminal Coronary Angioplasty (PTCA) Catheter
Status: UNKNOWN
Conditions: In-Stent Restenosis
Interventions: DEVICE: SeQuent® Please|DEVICE: SeQuent® II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Plerixafor (AMD3100) and Bevacizumab for Recurrent High-Grade Glioma
Status: TERMINATED
Conditions: High Grade Glioma: Glioblastoma (GBM)|High Grade Glioma: Gliosarcoma|Anaplastic Astrocytoma (AA)|Anaplastic Oligodendroglioma (AO)|Mixed Anaplastic Oligoastrocytoma (AOA)
Interventions: DRUG: Plerixafor|DRUG: Plerixafor|DRUG: Bevacizumab|DRUG: Plerixafor|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ-73763989, Pegylated Interferon Alpha-2a, Nucleos(t)Ide Analog (NA) With or Without JNJ-56136379 in Treatment-naive Participants With Hepatitis B e Antigen (HBeAg) Positive Chronic Hepatitis B Virus (HBV) Infection
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: JNJ-73763989|DRUG: PegIFN-alpha-2a|DRUG: Tenofovir disoproxil|DRUG: Tenofovir alafenamide|DRUG: JNJ-56136379
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of E-cigarette Flavors on Youth TCORS 2.0
Status: COMPLETED
Conditions: Nicotine Use Disorder
Interventions: DRUG: Flavoring Agents|DRUG: Nicotine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Antibiotyping and Prevalence of Virulent Genotypes Among Helicobacter Pylori and Their Impact on Response to Therapy
Status: UNKNOWN
Conditions: H Pylori Infection
Interventions: GENETIC: detection of vacuolating cytotoxin A (Vac A) and cytotoxin-associated gene A (Cag A) virulent H.Pylori genotypes by polymerase chain reaction amplification(PCR) in gastric biopsies :|DIAGNOSTIC_TEST: Culture and sensitivity of endoscopic gastric biopsies:|OTHER: Histopathological examination endoscopic gastric biopsies:|PROCEDURE: Upper endoscopy|DRUG: empirical H.pylori regimens|DIAGNOSTIC_TEST: H.Pylori Ag in stool
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effects of Evening Light Exposure on Melatonin Suppression, Alertness and Nocturnal Sleep
Status: COMPLETED
Conditions: Non-visual Photoreception
Interventions: DEVICE: Visible light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Estimate the Efficacy and Safety of Solifenacin in Female With Stress Urinary Incontinence and Urgency Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence|Urgency Urinary Incontinence
Interventions: DRUG: solifenacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glucagon-like Peptide-1 Metabolism and Acute Neprilysin Inhibition
Status: SUSPENDED
Conditions: Diabetes Mellitus, Type 2|Pre-diabetic|Hypertension|Elevated Blood Pressure
Interventions: DRUG: Sacubitril/Valsartan 200mg (blinded)|DRUG: Valsartan 160mg (blinded)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Ga68 V/Q PET/CT for Pulmonary Embolism Diagnosis: a Diagnostic Accuracy Study vs CT Pulmonary Angiography
Status: RECRUITING
Conditions: Pulmonary Embolism
Interventions: DIAGNOSTIC_TEST: V/Q PET/CT|DIAGNOSTIC_TEST: CTPA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetics and Safety/Tolerability of YY-201 in Comparison to Dutasteride and Tadalafil
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: Dutasteride 0.5 mg|DRUG: Tadalafil 5 mg|DRUG: YY-201
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vaginal Progesterone in Twins With Short Cervix
Status: WITHDRAWN
Conditions: Premature Birth
Interventions: DRUG: Vaginal Progesterone gel.|PROCEDURE: fetal fibronectin swab.|DRUG: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability and Efficacy Study of Sernova's Cell Pouch™ for Clinical Islet Transplantation
Status: RECRUITING
Conditions: Type 1 Diabetes Mellitus
Interventions: COMBINATION_PRODUCT: Sernova Cell Pouch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Effect of Bile Reflux on Gastric Cancer and Its Precancerous Lesions: a Cross-sectional Study.
Status: COMPLETED
Conditions: Bile Reflux Gastritis|Gastric Cancer|Helicobacter Pylori Infection|Intestinal Metaplasia|Precancerous Lesions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Virtual Tour of the Operating Theater on Fear and Anxiety of Preoperative Children
Status: UNKNOWN
Conditions: Preoperative Anxiety
Interventions: DEVICE: Cardboard VR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy Followed by Radiation Therapy With or Without Paclitaxel in Treating Patients With Unresectable Stage III Non-Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: chemotherapy|DRUG: cisplatin|DRUG: paclitaxel|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Antibiotic Therapy With or Without G-CSF in Treating Children With Neutropenia and Fever Caused by Chemotherapy
Status: COMPLETED
Conditions: Fever, Sweats, and Hot Flashes|Neutropenia|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: AD HOC Trial: Artificial Intelligence-Based Drug Dosing In Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Irinotecan|DRUG: Sonidegib|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter, Open, Randomized Comparative Trial To Compare The Efficacy Of Azithromycin Versus Amoxicillin In Children With Strep Throat
Status: COMPLETED
Conditions: Tonsillitis
Interventions: DRUG: Zithromax|DRUG: Clamoxyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Insect Protein on Performance and Hypertrophy
Status: COMPLETED
Conditions: Protein Supplementation
Interventions: DIETARY_SUPPLEMENT: Protein supplementation|OTHER: Resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Near-infrared Spectroscopy-based Neurofeedback as Adjunct to Mindfulness-Oriented Recovery Enhancement in Persons With Chronic Pain
Status: RECRUITING
Conditions: Chronic Pain Syndrome|Opioid Use
Interventions: BEHAVIORAL: Mindfulness-Oriented Recovery Enhancement|OTHER: Neurofeedback|BEHAVIORAL: Supportive Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate The Safety And Tolerability Of SB-656933-AAA Following Repeated Doses In Healthy Adult Subjects
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: SB-656933-AAA|DRUG: Matching placebo|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety and Efficacy Study of Fasinumab in Patients With Pain Due to Osteoarthritis (OA) of the Knee or Hip
Status: COMPLETED
Conditions: Osteoarthritis of the Knee or Hip
Interventions: DRUG: Fasinumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chronic Kidney Disease and Cardiovascular Disease Risk Assessment
Status: WITHDRAWN
Conditions: Chronic Kidney Diseases|Diabetes Mellitus|Hypertension
Interventions: DIAGNOSTIC_TEST: Hemoglobin A1C|DIAGNOSTIC_TEST: Urinalysis|DIAGNOSTIC_TEST: Whole blood creatinine level
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metacognitive Training as a Serious Game
Status: RECRUITING
Conditions: Schizophrenia and Related Disorders|Psychotic Disorders|Delusions
Interventions: DEVICE: Metacognitive training game|DEVICE: Control games
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Further Assess Safety and Effectiveness Data of the Bortezomib(Velcade)/Melphalan/Prednisone (BMP) Regimen in Previously Untreated and Transplant Ineligible Multiple Myeloma Patients
Status: NO_LONGER_AVAILABLE
Conditions: Multiple Myeloma
Interventions: DRUG: bortezomib|DRUG: bortezomib|DRUG: melphalan|DRUG: prednisone
Study Type: EXPANDED_ACCESS
Clinical trial: Randomised Controlled Trial to Investigate the Effect of Parental Presence at Intensive Care Unit to Ward Transfer Bedside Rounds on Parental Anxiety and Children's Safety
Status: COMPLETED
Conditions: Parental Anxiety|Children's Safety
Interventions: OTHER: Parental Presence at Handover Rounds
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rituximab Combined With Cyclosporine Versus Rituximab Alone in the Treatment of iMN
Status: RECRUITING
Conditions: Idiopathic Membranous Nephropathy
Interventions: DRUG: Rituximab|DRUG: cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Idiopathic Intracranial Hypertension Treatment Trial
Status: COMPLETED
Conditions: Idiopathic Intracranial Hypertension
Interventions: DRUG: Acetazolamide|DRUG: Placebo|BEHAVIORAL: Formal weight loss counselling program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Efficacy of Continuous Theta-burst Stimulation for Essential Tremor: A Randomized Study.
Status: COMPLETED
Conditions: Essential Tremor|Continuous Theta Burst Stimulation
Interventions: DEVICE: continuous theta-burst stimulation (cTBS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-preeclampsia Renal Project: Study of Nephroprotection in Women Having Suffered Preeclampsia
Status: COMPLETED
Conditions: Renal Alteration
Interventions: DRUG: Placebo|DRUG: Benazepril hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Anticariogenic Effect of Miswak (Silvadora Persica) and Grape Seed Extract
Status: COMPLETED
Conditions: Dental Caries
Interventions: OTHER: Miswak|OTHER: Grape Seed Extract Mouthwash|OTHER: fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Repeat Dose Positron Emission Tomography Study With GSK1144814
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: GSK1144814|DRUG: GSK1144814|DRUG: GSK1144814
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety of Once-daily Hydrocodone Bitartrate (HYD) Tablets For Moderate to Severe Chronic Nonmalignant and Nonneuropathic Pain. Includes a 24-week Extension Period.
Status: COMPLETED
Conditions: Chronic Nonmalignant and Nonneuropathic Pain
Interventions: DRUG: Hydrocodone bitartrate q24h film-coated tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of NMES Associated to Vascular Occlusion in Functional Performance and Muscle Hypertrophy in Athlete's
Status: COMPLETED
Conditions: Electric Stimulation Therapy|Muscle Strength
Interventions: DEVICE: NMES|DEVICE: Vascular Occlusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Subcutaneous Methylnaltrexone for Opioid-Induced Constipation in Patients With Advanced Illness
Status: COMPLETED
Conditions: Opioid-Induced Constipation
Interventions: DRUG: Methylnaltrexone bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy of Double Monopolar Versus Interleaving Stimulation Modes for Pallidal Deep Brain Stimulation
Status: COMPLETED
Conditions: Primary Dystonia
Interventions: DEVICE: Interleaving stimulation mode (Medtronic)|DEVICE: Double monopolar stimulation mode (Medtronic)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk Factors of Outcomes Associated With Disease Progression in Patients With Atrial Fibrillation and Heart Failure (HF) Who Are Receiving a Direct Oral Anticoagulant (Rivaroxaban)
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Trastuzumab Emtansine in Chinese Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Locally Advanced or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: Trastuzumab Emtansine|DRUG: Lapatinib|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1-2 of ST316 With Selected Advanced Unresectable and Metastatic Solid Tumors
Status: RECRUITING
Conditions: Breast Cancer Metastatic|Pancreatic Cancer|NSCLC, Metastatic|Synovial Sarcoma|Colon Cancer|Metastatic Colon Cancer|Melanoma Recurrent|Metastatic Skin Cancer|Melanoma Stage IV|Triple Negative Breast Cancer|TNBC - Triple-Negative Breast Cancer|Cholangiocarcinoma|Ovarian Cancer|Metastatic Melanoma|Hepatocellular Carcinoma
Interventions: DRUG: ST316|DRUG: FOLFIRI regimen & bevacizumab|DRUG: Fruquintinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Periodontal Therapy Effect on the Ratio of TNF-α to IL-10 in Periodontis With/Out DM
Status: COMPLETED
Conditions: Periodontitis Generalized
Interventions: PROCEDURE: non surgical periodontal therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Elimination of Adjuvant Chemotherapy for Selected Stage II and III Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Nasopharyngeal Cancer
Interventions: RADIATION: Radiotherapy|DRUG: Cisplatin|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genomics Used to Improve DEpression Decisions
Status: COMPLETED
Conditions: Major Depressive Disorder (MDD)
Interventions: GENETIC: GeneSight Psychotropic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Patient Satisfaction Improving Patient Satisfaction
Status: COMPLETED
Conditions: Satisfaction|Trauma
Interventions: OTHER: Orthopaedic Attending Biosketch Card|OTHER: Standard of care - No biosketch card
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Fixed Dose Combination Amlodipine + Enalapril Bioavailability Study
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: GSK2944404 FDC|DRUG: Amlodipine 5 mg|DRUG: Enalapril Maleate 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Adalimumab With Methotrexate for Treatment of Patients With Ulcerative Colitis (UC)
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: DRUG: MTX 12.5|DRUG: MTX 25|DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reduce Ventricular Pacing in Dual Chamber Implantable Cardioverter Defibrillators Using AutoIntrinsic Conduction Search Study
Status: COMPLETED
Conditions: Arrhythmia
Interventions: DEVICE: Autointrinsic Conduction Search Algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Care in Certified Cancer Centres in Germany
Status: COMPLETED
Conditions: Colorectal Cancer|Breast Cancer|Ovarian Cancer|Cervix Cancer|Endometrial Cancer|Bronchial Cancer|Prostate Cancer|Head and Neck Tumor|CNS Tumor|Pancreatic Cancer
Interventions: OTHER: Oncological certification
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tofacitinib In Psoriatic Arthritis Subjects With Inadequate Response to TNF Inhibitors
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Tofacitinib|DRUG: Tofacitinib|OTHER: Placebo|DRUG: Tofacitinib|OTHER: Placebo|DRUG: Tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ice Chips or Saline Mouth Rinse in Reducing or Preventing Mucositis in Patients Receiving Melphalan and Autologous Stem Cell Transplant for Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma|Plasma Cell Neoplasm
Interventions: DRUG: chemoprotection|PROCEDURE: complementary or alternative medicine procedure|PROCEDURE: management of therapy complications
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of LOXO-435 in Participants With Cancer With a Change in a Gene Called FGFR3
Status: RECRUITING
Conditions: Urinary Bladder Neoplasms|Neoplasm Metastasis|Ureteral Neoplasms
Interventions: DRUG: LOXO-435|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Study on Optimize Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Rectal Cancer
Interventions: DRUG: Induction chemotherapy, Chemoradiotherapy and gap chemotherapy (Capecitabine combine with oxaliplatin)|RADIATION: standard chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long-term, Safety, Tolerability, and Efficacy Study of Retigabine Immediate-release (IR) in Asian Adults With Partial Onset Seizures
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Retigabine IR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sitagliptin on Postprandial Lipoprotein Metabolism
Status: TERMINATED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: sitagliptin|DRUG: glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Medication Treatment for Opioid Use Disorder in Expectant Mothers: Infant Neurodevelopmental Outcomes Sub-study
Status: RECRUITING
Conditions: Opioid-Related Disorders|Drug Addiction|Pregnancy Related|Substance Abuse|Drug Abuse|Neonatal Abstinence Syndrome|Neonatal Opiate Withdrawal Syndrome|Drug Abuse in Pregnancy
Interventions: DRUG: Buprenorphine Injection|DRUG: Buprenorphine Sublingual Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Urine-Based DNA Methylation Biomarkers for Urothelial Bladder Carcinoma Detection in Patients With Hematuria
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: PROCEDURE: Cystoscopy|DIAGNOSTIC_TEST: Computed tomography|GENETIC: DNA hypermethylation assay|DIAGNOSTIC_TEST: Urine cytology
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of the COVID-19 Pandemic in Gynecological Oncology
Status: COMPLETED
Conditions: Gynecologic Cancer|Breast Neoplasm Female|Uterine Neoplasms|Ovarian Neoplasms|Uterine Cervical Neoplasms|Vulvar Neoplasms|Vaginal Neoplasms
Interventions: OTHER: modification of the planned therapeutic management
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ketamine Versus Co-administration of Ketamine and Propofol for Procedural Sedation in a Pediatric Emergency Department
Status: COMPLETED
Conditions: Procedural Sedation and Analgesia
Interventions: DRUG: Ketamine|DRUG: Ketamine Co-administered with Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Obstructive Sleep Apnea and Genes Expression
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea
Interventions: PROCEDURE: Continuous Positive Airway Pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Between M-Pro and ProTaper Next
Status: COMPLETED
Conditions: Symptomatic Irreversible Pulpitis
Interventions: PROCEDURE: M-pro files in rotating motion|PROCEDURE: ProTaper Next files in rotating motion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Platelet Inhibitory Effect of Clopidogrel in Patients Treated With Omeprazole, Pantoprazole, or Famotidine
Status: COMPLETED
Conditions: Coronary Heart Disease|GI Bleeding
Interventions: DRUG: omeprazole, 20mg twice daily|DRUG: famotidine 40mg twice daily|DRUG: pantoprazole 40mg once daily
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First-in-Human Phase I Study of ESG206 in Subjects With B-cell Lymphoid Malignancies
Status: NOT_YET_RECRUITING
Conditions: B-cell Lymphoid Malignancies
Interventions: DRUG: ESG206
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The DANCEREX Proof-of-Concept Study for Chronic Neurological Disorders
Status: NOT_YET_RECRUITING
Conditions: Sclerosis, Multiple|Neurocognitive Impairment, Mild|Neurocognitive Dysfunction
Interventions: DEVICE: DANCEREX-DTx|DEVICE: Multidimensional dance-based program|DEVICE: Educational Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing the Safety and Efficacy of IDP-120 Gel and IDP-120 Vehicle Gel in the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: IDP-120 Gel|DRUG: IDp-120 Vehicle Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Application of Highly Concentrated Water-in-oil Emulsions
Status: COMPLETED
Conditions: Skin Physiology|Dermal Administration|Emulsions
Interventions: OTHER: Application of emulsion|PROCEDURE: Measurement of physiological skin parameters|PROCEDURE: Tape stripping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Homing in on Health: Study of a Home Delivered Chronic Disease Self Management Program
Status: COMPLETED
Conditions: Diabetes Mellitus|Congestive Heart Failure|Arthritis|COPD|Depression
Interventions: BEHAVIORAL: Homing in on Health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Ravulizumab in Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN)
Status: RECRUITING
Conditions: Lupus Nephritis|Immunoglobulin A Nephropathy
Interventions: DRUG: Ravulizumab|DRUG: Placebo|OTHER: Background Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glycemic Response to Two Doses of Low Sugar Apple Juice
Status: COMPLETED
Conditions: Prediabetes
Interventions: OTHER: 500 ml glucose-depleted apple juice|OTHER: 500 ml conventional apple juice|OTHER: 250 ml glucose-depleted apple juice|OTHER: 250 ml conventional apple juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER