pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pemigatinib for the Treatment of Patients With Relapsed or Refractory Mantle Cell Lymphoma or Marginal Zone Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Recurrent Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Nodal Marginal Zone Lymphoma|Recurrent Splenic Marginal Zone Lymphoma|Refractory Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue|Refractory Mantle Cell Lymphoma|Refractory Marginal Zone Lymphoma|Refractory Nodal Marginal Zone Lymphoma|Refractory Splenic Marginal Zone Lymphoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Computed Tomography|DRUG: Pemigatinib|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genomics-Based Target Therapy for Children With Relapsed or Refractory Malignancy
Status: UNKNOWN
Conditions: Relapsed Pediatric Solid Tumor|Refractory Pediatric Solid Tumor|Relapsed Pediatric AML|Refractory Pediatric AML
Interventions: PROCEDURE: CancerSCAN™|DRUG: Ifosfamide|DRUG: Carboplatin|DRUG: Etoposide|DRUG: Fludarabine|DRUG: Cytarabine|DRUG: Pazopanib|DRUG: Sorafenib|DRUG: Axitinib|DRUG: Crizotinib|DRUG: Dasatinib|DRUG: Erlotinib|DRUG: Everolimus|DRUG: Imatinib|DRUG: Ruxolitinib|DRUG: Vandetanib|DRUG: Vemurafenib|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Personalized Normative Feedback Repeatedly Delivered Via a Mobile Application After a Brief Therapeutic Intervention on Alcohol-related Risks:
Status: TERMINATED
Conditions: Acute Alcohol Intoxication
Interventions: OTHER: Personalized Normative Feedback|OTHER: Brief Therapeutic Intervention|OTHER: Evaluation questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy, Immunogenicity and Safety of S. Flexneriza-S. Sonnei Bivalent Conjugate Vaccine in Volunteers Aged From 6 Months to 5 Years
Status: UNKNOWN
Conditions: Dysentery|Shigellosis
Interventions: BIOLOGICAL: S. Flexneriza-S. Sonnei Bivalent Conjugate Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 1 Trial of CBL0137 in Patients With Metastatic or Unresectable Advanced Solid Neoplasm
Status: COMPLETED
Conditions: Solid Tumors|Glioblastoma
Interventions: DRUG: CBL0137
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radial Tunnel Syndrome in Resistant Lateral Epicondylitis
Status: COMPLETED
Conditions: Radial Tunnel Syndrome|Lateral Epicondylitis|Radial Nerve Compression|Epicondylitis of the Elbow
Interventions: DIAGNOSTIC_TEST: diagnostic posterior interosseous nerve lidocaine injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The ASCEND Study: Gemcitabine and Nab-Paclitaxel With CEND-1/LSTA1 or Placebo in Patients With Untreated Metastatic Pancreatic Ductal Adenocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma|Metastatic Pancreatic Cancer
Interventions: DRUG: CEND-1/LSTA1|DRUG: Gemcitabine Injection|DRUG: Nab paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Metabolic and Muscular Adaptations During Inactivity in 3 Days of Bed-rest
Status: COMPLETED
Conditions: Muscle Atrophy|Insulin Sensitivity
Interventions: OTHER: Bed Rest|OTHER: Reconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Coronavirus 2019 (COVID-19)- Using Ascorbic Acid and Zinc Supplementation
Status: COMPLETED
Conditions: COVID|Corona Virus Infection
Interventions: DIETARY_SUPPLEMENT: Ascorbic Acid|DIETARY_SUPPLEMENT: Zinc Gluconate|DIETARY_SUPPLEMENT: Ascorbic Acid and Zinc Gluconate|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Chemotherapy and PD-1 Inhibitor Combination With Autologous CIK Cell Immunotherapy to Treat Lung Cancer
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer Metastatic|First-line Treatment
Interventions: BIOLOGICAL: CIK cell injection|DRUG: Sintilimab Injection|DRUG: Pemetrexed|DRUG: Albumin paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes of Biologically Oriented Preparation Technique
Status: RECRUITING
Conditions: Crowns|Tooth Preparation
Interventions: PROCEDURE: Biologically-oriented preparation technique|PROCEDURE: Conventional method of preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Lung Cancer-Related Anxiety (RELAX)
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DEVICE: Group A - Device guided breathing low dose|DEVICE: Group B - Device guided breathing high dose|DEVICE: Group C - Usual Breathing Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of CPAP vs Control on Nocturnal Dipping in Normotensive Patients With Obstructive Sleep Apnea
Status: WITHDRAWN
Conditions: Sleep Apnea, Obstructive
Interventions: DEVICE: CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Tolerability, Safety and Efficacy Study of RJMty19 in Subjects With Relapsed or Refractory B-NHL
Status: NOT_YET_RECRUITING
Conditions: B-cell Non-Hodgkin's Lymphoma
Interventions: BIOLOGICAL: RJMty19 (CD19-CAR-DNT cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The PainSMART Research Program: Evaluating a Pain Education Strategy for Patients Seeking Primary Care Physiotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain|Pain Acute|Pain, Chronic|Self Efficacy|Illness Perceptions|Physical Activity Level|Sickness Absence|Referral and Consultation|Worry|Anxiety|Patient-Centered Care|Communication
Interventions: OTHER: PainSMART-strategy|OTHER: Usual physiotherapy management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxidative Stress Markers in Open and Laparoscopic Colectomy for Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: PROCEDURE: Open colectomy|PROCEDURE: laparoscopic colectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Enhancing Access to Supportive Services for Women of Color With Metastatic Breast Cancer
Status: RECRUITING
Conditions: Metastatic Breast Cancer|Stage IV Breast Cancer AJCC V7
Interventions: BEHAVIORAL: ACCESS Supportive Care|BEHAVIORAL: Phone sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study Evaluating Effects of Pharmacogenetic-guided vs Standard-of-Care Treatment on Depression and/or Anxiety
Status: COMPLETED
Conditions: Depression|Anxiety
Interventions: GENETIC: IDgenetix Neuropsychiatric Test Panel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: PMCF Study on the Safety, Performance and Clinical Benefits Data of the ToggleLoc™ 2.9mm in the Elbow
Status: ACTIVE_NOT_RECRUITING
Conditions: Epicondylitis of the Elbow|Biceps Tendon Disorder
Interventions: DEVICE: ToggleLoc 2.9 mm Soft Tissue System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Ondansetron Premedication Trial in Juvenile Idiopathic Arthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Juvenile Idiopathic Arthritis
Interventions: DRUG: Methotrexate|DRUG: Ondansetron|DRUG: Folic/folinic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study for Optimizing Anti-inflammatory Prophylaxis
Status: COMPLETED
Conditions: Postoperative Cystoid Macular Edema|Irvine-Gass Syndrome
Interventions: DRUG: NSAID + prednisolone, preoperative|DRUG: NSAID + prednisolone, postoperative|DRUG: NSAID, preoperative|DRUG: NSAID, postoperative|DRUG: Drop-less surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Bacteroides Thetaiotaomicron in Young People Aged 16 to 18 Years With Stable Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: OTHER: Thetanix|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Ofatumumab in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Adult Acute Lymphoblastic Leukemia in Complete Remission|Burkitt Leukemia|Burkitt Lymphoma|CD20 Positive|Childhood Acute Lymphoblastic Leukemia in Complete Remission|Lymphoblastic Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Dexamethasone|DRUG: Doxorubicin Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Methotrexate|BIOLOGICAL: Ofatumumab|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Cilotax Stent and Everolimus -Eluting Stent With Diabetes Mellitus (ESSENCE-DM III)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Xience Prime|DEVICE: Cilotax stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Marathon and Enduron Polyethylene at Long-Term Follow-up
Status: COMPLETED
Conditions: Osteoarthritis|Arthritis|Joint Diseases|Musculoskeletal Diseases|Rheumatic Diseases
Interventions: DEVICE: Hip Replacement with crosslinked Marathon polyethylene|DEVICE: Hip Replacement with noncrosslinked Enduron polyethylene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-Blind, Placebo-Controlled Phase 2a, Proof-of-Concept Trial of ADX-914 Phase 2a Trial for the Treatment of Severe Alopecia Areata
Status: ACTIVE_NOT_RECRUITING
Conditions: Alopecia Areata
Interventions: DRUG: ADX-914|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zinc Supplementation in Cirrhotic Patients
Status: UNKNOWN
Conditions: Dysgeusia|Liver Cirrhosis
Interventions: DIETARY_SUPPLEMENT: zinc gluconate|DIETARY_SUPPLEMENT: Placebo|BEHAVIORAL: Nutritional education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dietary Sodium and Potassium Citrate on Renal Mineral Handling
Status: UNKNOWN
Conditions: Kidney Stone
Interventions: DIETARY_SUPPLEMENT: Sodium and Potassium Citrate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Investigating the Association Between Microbiota and Esophageal/Oropharyngeal Cancer
Status: RECRUITING
Conditions: Microbial Colonization|Esophageal Cancer|Oropharyngeal Neoplasms|Synchronous Neoplasm
Interventions: DIAGNOSTIC_TEST: Oral swab test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Fermented Milk Drink on Human Intestinal Microflora
Status: COMPLETED
Conditions: Signs and Symptoms, Digestive
Interventions: DIETARY_SUPPLEMENT: Yakult®300|DIETARY_SUPPLEMENT: Lactobacillus casei strain Shirota
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: COVID-19 and Nonalcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Covid19|NAFLD
Interventions: DIAGNOSTIC_TEST: Th17 cytokine profile|DIAGNOSTIC_TEST: Screening for the components of metabolic syndrome|DIAGNOSTIC_TEST: Evaluation of the degree of steatosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Testing the Efficacy and Safety of BIO101 for the Prevention of Respiratory Deterioration in COVID-19 Patients
Status: TERMINATED
Conditions: Covid-19|SARS-CoV2
Interventions: DRUG: BIO101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Drug-Drug Interaction Study to Estimate the Effect of PF-07081532 on the Pharmacokinetics of Dabigatran and Rosuvastatin in Overweight or Obese Adult Participants
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: Dabigatran etexilate (DE)|DRUG: Rosuvastatin|DRUG: PF-07081532
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-centre 3-arm Randomised Phase II Trial of BIBF 1120 Versus BIBW 2992 Versus Sequential Administration of BIBF 1120 and BIBW 2992 in Patients With Hormone-resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: BIBF 1120|DRUG: BIBW 2992|DRUG: Sequential BIBF 1120 + BIBW 2992
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Serial [18F]Fluorodeoxyglucose ([18F]FDG )PET/CT as a Biomarker of Therapeutic Response in Anti-PD1/PDL1 Therapy
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer (NSCLC)
Interventions: RADIATION: [18F]fluoroglucose(FDG)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Measure Calorie Consumption and Usage in Participants With Obesity Using LY3437943
Status: RECRUITING
Conditions: Obesity
Interventions: DRUG: LY3437943|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of Two Formulations of Sarpogrelate HCl 300mg Tablets Under Fed Conditions
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Sarpogrelate HCL 300mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Health Information Technology (HIT) to Improve Transitions of Complex Elderly Patients From Skilled Nursing Facility (SNF) to Home
Status: COMPLETED
Conditions: Adverse Outcomes
Interventions: OTHER: Intervention 1: Electronic medical record (EMR)-based transitional care intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Trial of Human (Allogeneic) iPS Cell-derived Cardiomyocytes Sheet for Ischemic Cardiomyopathy
Status: UNKNOWN
Conditions: Myocardial Ischemia
Interventions: BIOLOGICAL: Human (allogeneic) iPS cell derived-cardiomyocyte sheet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Motivational Effect of Choosing Taste of te Fluoride Varnish on Behavior During Dental Visit in Children - RCT
Status: COMPLETED
Conditions: Child Behavior
Interventions: BEHAVIORAL: effect of choice on cooperation (pseudoalternative)|BEHAVIORAL: given fluoride varnish (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Registry to Collect Information on Pregnancy, Neonatal, and Infant Outcomes in Pregnant Women Exposed to QUVIVIQ®
Status: NOT_YET_RECRUITING
Conditions: Insomnia
Interventions: DRUG: Daridorexant|DRUG: Non-orexin receptor antagonist medications for insomnia|OTHER: No insomnia medication
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Perceived Satisfaction With the Use of the Dreeft® Device in Real-life Situations
Status: RECRUITING
Conditions: People With Motor Disabilities
Interventions: DEVICE: Dreeft wheels (EPPUR company)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Determine Ethnic Differences in the Glycaemic Response to Nutritional Formula Drinks
Status: COMPLETED
Conditions: Diabetes|Impaired Glucose Tolerence
Interventions: DIETARY_SUPPLEMENT: Liquid-based Nutritional Formulae and liquid glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Whether Dexmedetomidine Can Improve the Prognosis of Elderly Patients With Postoperative Cognitive Dysfunction
Status: COMPLETED
Conditions: Postoperative Cognitive Dysfunction|Postoperative Delirium
Interventions: DRUG: Dexmedetomidine|DRUG: Sufentanyl|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prevention of Injury in Skilled Nursing Facilities Through Optimizing Medications
Status: NOT_YET_RECRUITING
Conditions: Accidental Falls/Prevention and Control|Osteoporosis
Interventions: OTHER: Deprescribing Care Model|OTHER: Bone Health Service Model|OTHER: Injury Prevention Service Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Three Different Treatment Regimes in Early Rheumatoid Arthritis: A Randomized Open-labelled Trial
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Combination Steroid|DRUG: Methotrexate|DRUG: Combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenetic Study of Different Hormone Therapies in Recent Menopause Women
Status: COMPLETED
Conditions: Postmenopause
Interventions: DRUG: Estradiol and Progesterone|DRUG: Estradiol and Drospirenone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Construction-LBD (Constructional Apraxia in Alzheimer's Disease (AD) and Lewy Body's Dementia (LBD))
Status: UNKNOWN
Conditions: Alzheimer's Disease|Lewy Body's Dementia
Interventions: OTHER: Rey figure test|OTHER: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: VR Simulation and Basic Skills in THA
Status: RECRUITING
Conditions: Educational Problems|Hip Arthroplasty|Osteoarthritis, Hip|Medical Students
Interventions: PROCEDURE: VR simulation on basic THA skills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Treatment of Chronic Cough in Idiopathic Pulmonary Fibrosis With Thalidomide
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis|Cough
Interventions: DRUG: Thalidomide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Control of Hypertension and diAbetes in MINas Gerais
Status: ENROLLING_BY_INVITATION
Conditions: Arterial Hypertension|Diabetes Mellitus
Interventions: OTHER: Multidimensional intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Rotational Thromboelstometry (ROTEM) change_colloid_total Hip Replacement Arthroplasty
Status: COMPLETED
Conditions: Avascular Necrosis of Hip|Total Hip Replacement Arthroplasty
Interventions: DRUG: Pentaspan, voluven, volulyte
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Minimum Effective Concentration of Bupivacaine in Ultrasound-guided Axillary Brachial Plexus Block
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long Term Safety and Tolerability Study in Approximately 350 Subjects With Moderate to Severe Chronic, Non-malignant Pain
Status: COMPLETED
Conditions: Moderate to Severe Chronic, Non-malignant Pain
Interventions: DRUG: Hydrocodone/Acetaminophen on Extended Release
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Radiological Tubal Blockage Versus Laparoscopic Salpingectomy in Infertile Women With Hydrosalpinx During in Vitro Fertilization Treatment
Status: WITHDRAWN
Conditions: IVF-ET|Hydrosalpinx
Interventions: PROCEDURE: radiological tubal blockage|PROCEDURE: laparoscopic salpingectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fascia Iliaca Compartment Block Versus Quadratus Lumborum Block in Total Hip Arthroplasty
Status: COMPLETED
Conditions: Nerve Block|Pain, Postoperative
Interventions: PROCEDURE: fascia iliaca compartement block|PROCEDURE: quadratus lumborum block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short-term Cardiovascular Benefits of Wearing Particulate-filtering Respirators
Status: COMPLETED
Conditions: Autonomic Nervous System Imbalance|Blood Pressure|Inflammation|Vasoconstriction|Blood Coagulation Disorders
Interventions: BEHAVIORAL: Wear respirator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of A-101 Topical Solution Administered Twice a Week in Subjects With Common Warts
Status: COMPLETED
Conditions: Common Wart
Interventions: DRUG: A-101 Topical Solution|DRUG: A-101 Vehicle Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Investigate Safety, Tolerability, And Pharmacokinetics Of PF-00868554 In Japanese Healthy Adult Volunteers
Status: TERMINATED
Conditions: Healthy Volunteers
Interventions: DRUG: PF-00868554 or Placebo|DRUG: PF-00868554 or Placebo|DRUG: PF-00868554 or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Pedopsychiatric and Multidisciplinary Research Devoted to Children Exposed to the Attack in Nice on July 14, 2016
Status: ACTIVE_NOT_RECRUITING
Conditions: Psychiatric Disorder|Trauma, Psychological
Interventions: BEHAVIORAL: Child and adolescent psychiatry and Epidemiology|OTHER: salivary biological collection|BEHAVIORAL: qualitative analysis of the discourse|BEHAVIORAL: Parenthood|BEHAVIORAL: Cognitive alterations|BEHAVIORAL: Impact on schooling|BEHAVIORAL: Sleep disorders and associated somatizations
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Maternal Diabetes on Brain Development, as Measured by Neonatal Electroencephalogram (EEG)
Status: COMPLETED
Conditions: Diabetes in Pregnancy|Diabetes, Gestational|Infant, Newborn, Diseases|Perinatal Disorders of Growth and Development
Interventions: OTHER: Video Electroencephalogram (EEG)|OTHER: Point-of Care Blood Sugar Testing|OTHER: Medical Record Data Extraction|OTHER: Maternal Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ecological Momentary Intervention for Stroke Caregivers' Psychological Support
Status: COMPLETED
Conditions: Stroke|Caregiver Burnout|Depressive Symptoms|Psychological Distress|Mobile Phone Use
Interventions: OTHER: iCBT-based EMI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Applying High Resolution Impedance Manometry for Perioperative Swallowing Changes in Older Patients Receiving Endotracheal Intubation or Supraglottic Airway Devices During Orthopedic Surgery
Status: COMPLETED
Conditions: Hypopharyngeal Mean Pressure
Interventions: DEVICE: supraglottic airway device|DEVICE: endotracheal intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of MegaCarti^® in Knee Cartilage Defects
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: MegaCarti^®|PROCEDURE: Microfracture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate Investigational Silicone Hydrogel Contact Lenses Worn Continuously for One Week
Status: COMPLETED
Conditions: Visual Disorder
Interventions: DEVICE: Investigational Lens 1|DEVICE: Investigational Lens 2|DEVICE: Investigational Lens 3|DEVICE: etafilcon A (Reusable)|DEVICE: etafilcon A (1-Day)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-operative vs. Operative Management of Acute Appendicitis in Vulnerable Patient Populations
Status: WITHDRAWN
Conditions: Acute Appendicitis
Interventions: PROCEDURE: Laparoscopic appendectomy|DRUG: Antibiotics (IV transitioned to oral)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Trial of the Combination of Zidovudine and Recombinant Interleukin-2 in Patients With Persistent Generalized Lymphadenopathy
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zidovudine|DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of CRD-4730 in Participants With Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
Status: RECRUITING
Conditions: CPVT1|Heart Defects, Congenital|Heart Diseases|Ventricular Tachycardia
Interventions: DRUG: CRD-4730|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Faldaprevir, TD-6450 and Other Antivirals in Participants With Genotype 1b Hepatitis C Virus Infection
Status: COMPLETED
Conditions: Hepatitis C Viral Infection|Chronic Hepatitis C|Hepatitis C (HCV)|Hepatitis C Genotype 1
Interventions: DRUG: Faldaprevir|DRUG: TD-6450|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perhexiline Therapy in Heart Failure With Preserved Ejection Fraction Syndrome
Status: COMPLETED
Conditions: Diastolic Heart Failure
Interventions: DRUG: Perhexiline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Disease
Status: TERMINATED
Conditions: Hyperkalaemia|Metabolic Acidosis|Chronic Kidney Disease
Interventions: DRUG: Sodium zirconium cyclosilicate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Expectation and Response to Levodopa and Acupuncture in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: BEHAVIORAL: Levodopa or acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Learn How Safe the Study Treatment Elinzanetant is and How it Moves Into, Through and Out of the Body When Given as Single Increasing Doses That Are Higher Than Normally Used Compared to Placebo and Moxifloxacin in Healthy Participants
Status: COMPLETED
Conditions: Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men|Hot Flashes|Healthy Volunteers
Interventions: DRUG: Moxifloxacin|DRUG: Elinzanetant (BAY3427080)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Long-Term Study To Evaluate Safety And Efficacy Of Pregabalin In Patients With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: pregabalin (Lyrica)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neptune Krill Oil (NKO™) in Early Stage Alzheimer's Disease (MNEMOSYNE)
Status: COMPLETED
Conditions: Early Onset Alzheimer Disease
Interventions: DIETARY_SUPPLEMENT: Neptune Krill Oil|DIETARY_SUPPLEMENT: Fish Oil|DIETARY_SUPPLEMENT: Placebo (soy oil)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Network Medicine Approaches to Classify Heart Failure With PReserved Ejection Fraction by Signatures of DNA Methylation and Point-of-carE Risk calculaTors (PRESMET)
Status: COMPLETED
Conditions: Heart Failure, Diastolic|Heart Failure, Systolic|Pulmonary Hypertension|Atrial Fibrillation
Interventions: OTHER: RRBS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors
Status: RECRUITING
Conditions: Hodgkin Lymphoma|Non-Hodgkin Lymphoma
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of TKI Combined With Chemotherapy and Sequential CAR-T Cells in ND Adult Patients With Ph+ ALL
Status: NOT_YET_RECRUITING
Conditions: Philadelphia Positive Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia, Adult
Interventions: COMBINATION_PRODUCT: CAR-T cells|DRUG: Venetoclax|DRUG: Olverembatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single or Double-layer Uterine Closure Techniques
Status: COMPLETED
Conditions: Uterine Scar|Cesarean Section Complications|Cesarean Section; Dehiscence
Interventions: DIAGNOSTIC_TEST: Residual myometrium thickness|DIAGNOSTIC_TEST: Niche Presence|DIAGNOSTIC_TEST: Adjacent myometrium thickness|DIAGNOSTIC_TEST: Niche Measurements (depth of niche, width of niche, length of niche)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Open-label Long-term Extension Study of Fesoterodine in Japanese Subjects With Neurogenic Detrusor Overactivity.
Status: COMPLETED
Conditions: Urinary Bladder, Neurogenic
Interventions: DRUG: Fesoterodine PR 4 mg|DRUG: Fesoterodine PR 8 mg|DRUG: Fesoterodine BIC 2 mg|DRUG: Fesoterodine BIC 4 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pediatrics Testotoxicosis Study [Bicalutamide Anastrozole Treatment for Testotoxicosis]
Status: COMPLETED
Conditions: Puberty, Precocious
Interventions: DRUG: Bicalutamide|DRUG: Anastrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pregnenolone for Cognitive and Negative Symptoms in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Dietary Supplement: Pregnenolone|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men to Test How BI 685509 is Processed in the Body
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: [¹⁴C] BI 685509 formulation 1|DRUG: [¹⁴C] BI 685509 formulation 2|DRUG: BI 685509 formulation 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Free Gingival Graft Versus Connective Tissue Graft
Status: UNKNOWN
Conditions: Gingival Recession|Gingival Recession, Localized
Interventions: PROCEDURE: Free gingival graft|PROCEDURE: Connective tissue graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cholesterol and Pharmacogenetic Study
Status: COMPLETED
Conditions: Hyperlipidemia|Hypercholesterolemia|Coronary Heart Disease|Cardiovascular Disease
Interventions: DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combining Armodafinil With Neuro-rehabilitation to Improve Neurological Recovery and Reduce Disability Post-Stroke
Status: COMPLETED
Conditions: Stroke|Cerebrovascular Accident|Hemiparesis
Interventions: DRUG: Armodafinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuropsychological Development and Executive Functioning of Children Born to HIV- Infected Mothers ( NEUROPSY-HEU )
Status: COMPLETED
Conditions: HIV Infections|Exposure During Pregnancy|Neurophysiologic Abnormality|Executive Dysfunction
Interventions: DIAGNOSTIC_TEST: BRIEF SCORE AT INCLUSION
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: J-Valve TF Early Feasibility Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Valve Disease|Aortic Valve Insufficiency|Aortic Regurgitation
Interventions: DEVICE: J-Valve TF System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Safety and Pharmacokinetics of SER120 Nasal Spray in Elderly Patients With Nocturia
Status: COMPLETED
Conditions: Nocturia
Interventions: DRUG: SER120 Nasal Spray 500 ng/day|DRUG: SER120 nasal spray 750 ng/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Ascites Drainage Versus Standard Care for Patients With Advanced Ovarian Cancer
Status: SUSPENDED
Conditions: Ascites|Ovarian Epithelial Cancer|Malnutrition
Interventions: DEVICE: Systematic ascites evacuation|PROCEDURE: Acute paracentesis.|BEHAVIORAL: Interview.|BEHAVIORAL: Quality of life.|BEHAVIORAL: Nutritional status.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: T-IR- Study to Understand the Effects of Testosterone and Estrogen on the Body's Response to the Hormone Insulin
Status: COMPLETED
Conditions: Insulin Resistance|Type 2 Diabetes Mellitus|Obesity|Androgen Deficiency|Metabolic Disease
Interventions: DRUG: Acyline|DRUG: Testosterone 1.62% gel|DRUG: Letrozole|DRUG: Placebo gel (for Testosterone 1.62% gel)|DRUG: Placebo pill (for Letrozole)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Electrical Dry Needling in Pain, Sensitivity, Functionality and Quality of Life of Patients With Chronic Non-specific Low Back Pain
Status: COMPLETED
Conditions: Chronic Low-back Pain
Interventions: OTHER: Electrical dry needling|OTHER: Ischemic compression, analytical stretching and postural habits educational dossier
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Anesthesia Technique on Endothelial Function
Status: NOT_YET_RECRUITING
Conditions: Endothelial Dysfunction|Ischemia Reperfusion|Oxidative Stress
Interventions: PROCEDURE: Group GA|PROCEDURE: Group IB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Efficacy, Safety and Pharmacokinetics Study of Simeprevir, Daclatasvir and Sofosbuvir in Participants With Chronic Hepatitis C Virus Genotype 1 or 4 Infection and Decompensated Liver Disease
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Simeprevir|DRUG: Daclatasvir|DRUG: Sofosbuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Basimglurant (NOE-101) in Patients With Trigeminal Neuralgia.
Status: RECRUITING
Conditions: Trigeminal Neuralgia
Interventions: DRUG: Basimglurant|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Incretin-based Drugs and the Risk of Heart Failure
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: DPP-4 inhibitors|DRUG: GLP-1 analogs|DRUG: Insulins|DRUG: Biguanides|DRUG: Sulfonylureas|DRUG: Thiazolidinediones|DRUG: Alpha-glucosidase inhibitors|DRUG: Meglitinides
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate Pharmacokinetics of Single Oral Doses of Formulated and Non-Formulated CC-122, and Food Effect Study
Status: COMPLETED
Conditions: Clinical Pharmacology, Healthy Male Volunteer Study
Interventions: DRUG: CC-122|DRUG: CC-122|DRUG: CC-122
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Pitavastatin on Monocyte, Endothelial Dysfunction and HDL-C in Subjects With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DRUG: Pitavastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study of Lithium Before and During Topiramate Dosing in Bipolar Disorder Patients
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: topiramate|DRUG: topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep and Memory in Children
Status: COMPLETED
Conditions: Sleep Apnea|Temporo-central Epilepsy|Narcolepsy|High Intellectual Potential|Healthy Subject
Interventions: OTHER: memory evaluation at V1 and V2 (with treatment)|OTHER: memory evaluation at V1 (without treatment)|OTHER: memory evaluation at V1 and V2 (without treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of the Efficacy of Topical Ibuprofen to Oral Ibuprofen in Adolescent Athletes
Status: TERMINATED
Conditions: Soft Tissue Injury
Interventions: DRUG: Ibuprofen|DRUG: ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ph II Atrasentan + DOXIL in Recurrent Ovarian/Fallopian/Peritoneal Serous Papillary Adenocarcinoma
Status: TERMINATED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Peritoneal Cavity Cancer
Interventions: DRUG: atrasentan hydrochloride|DRUG: doxil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BELIEF (Bevacizumab and ErLotinib In EGFR Mut+ NSCLC)
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Erlotinib|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of IMRT in Primary Bone and Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Soft Tissue Sarcoma, Adult|Ewing Sarcoma|Bone Sarcoma|Chordoma
Interventions: RADIATION: Intensity modulated radiotherapy (IMRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Administration of Ceftazidime-avibactam (CAZ-AVI) and Ceftaroline Fosamil -Avibactam (CXL) on the Intestinal Flora of Healthy Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics|Open Label|CAZ-AVI|CXL|Effect on Intestinal Flora|Safety
Interventions: DRUG: CAZ-AVI|DRUG: CXL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Efficacy of Simulation Manikins in the Military Medics Training
Status: ENROLLING_BY_INVITATION
Conditions: War-Related Injuries
Interventions: BEHAVIORAL: Conventional versus simulation manikin training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Study of Endocardial Myocardial Biopsy
Status: RECRUITING
Conditions: Myocarditis|Cardiomyopathies|Heart Failure|Cardiac Tumor|Endocardiomyocardial Biopsy
Interventions: PROCEDURE: Endocardiomyocardial biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: First in Human Study of TLC-ART 101 (ACTU 2001)
Status: RECRUITING
Conditions: Human Immunodeficiency Virus|Treatment|Antiretroviral Therapy
Interventions: DRUG: TLC-ART
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OFS in Premenopausal Node+ Breast Cancer With Low Genomic Risk
Status: RECRUITING
Conditions: Breast Cancer|Estrogen Receptor Positive Tumor|HER2-negative Breast Cancer|Premenopausal Breast Cancer|Node-positive Breast Cancer
Interventions: DRUG: Ovarian function suppression with endocrine treatments
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Orally Administered Thymus Vulgaris Leaves on Memory, Anxiety, Depression, and Sleep Quality in University Students: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Memory Dysfunction|Anxiety|Depression|Sleep
Interventions: DIETARY_SUPPLEMENT: Thymus vulgaris
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Premeal Consumption of Protein-enriched Bar on Blood Glucose Level and Secretion of Hormones
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: premeal protein-enriched bar intake|OTHER: breakfast follows by protein bar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ruxolitinib Plus LVP in Patients With R/R ETP-ALL
Status: UNKNOWN
Conditions: Acute T Cell Leukemia
Interventions: DRUG: Ruxolitinib|DRUG: Vincristine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1-2 Study of Onapristone in Patients With Progesterone Receptor Expressing Cancers
Status: UNKNOWN
Conditions: Progesterone Receptor Positive Tumor: Max 1 Line of Prior Chemotherapy, no Prior Hormone Therapy
Interventions: DRUG: onapristone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of Bleeding Disorders in EDS
Status: ENROLLING_BY_INVITATION
Conditions: Ehlers-Danlos Syndrome|EDS|Classical Ehlers-Danlos Syndrome|Classical EDS (cEDS)|Hypermobile Ehlers-Danlos Syndrome|Hypermobile EDS (hEDS)|Vascular Ehlers-Danlos Syndrome|Vascular EDS (vEDS)
Interventions: OTHER: 20 ml venous blood collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p