pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Effect of Dietary Intervation on Endothelial Glycocalyx in COVID-19 Patients.
Status: RECRUITING
Conditions: COVID-19|Endothelial Dysfunction
Interventions: DIETARY_SUPPLEMENT: Food supplement Endocalyx|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Two and Three Dimensional Contrast-enhanced Ultrasound for Screening of Renal Cell Carcinoma Recurrence Following Cryoablation
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Optison
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vaccine Therapy and Sargramostim in Treating Patients With Pancreas Cancer That Cannot Be Removed By Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Pancreatic Adenocarcinoma|Pancreatic Acinar Cell Carcinoma|Pancreatic Ductal Adenocarcinoma|Stage III Pancreatic Cancer AJCC v6 and v7|Stage IV Pancreatic Cancer AJCC v6 and v7
Interventions: BIOLOGICAL: Falimarev|BIOLOGICAL: Inalimarev|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of Adaptive Deep Brain Stimulation for OCD
Status: ACTIVE_NOT_RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: Summit RC+S System|OTHER: One Month Blinded Discontinuation Period:
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magrolimab Plus Intensive Chemotherapy in Newly Diagnosed AML or HR-MDS
Status: WITHDRAWN
Conditions: Acute Myeloid Leukemia|Myelodysplastic Neoplasm
Interventions: DRUG: Magrolimab|DRUG: 7+3|DRUG: CPX-351
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Sodium Divalproate Tablets 500 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Valproic Acid 500 MG|DRUG: Valcote 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Nebivolol for the Prevention of Left Ventricular Systolic Dysfunction in Patients With Duchenne Muscular Dystrophy
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy|Cardiomyopathy|Heart Failure
Interventions: DRUG: Nebivolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity of Catch-up Vaccination Regimens of V114 (V114-024)
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: V114|BIOLOGICAL: Prevnar 13®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Caring for Vets and Service Members: Caring Contacts for Stressed and Distressed Veterans and Service Members
Status: RECRUITING
Conditions: Stress|Distress, Emotional
Interventions: BEHAVIORAL: Caring Contacts|BEHAVIORAL: Best Available Resources Alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Picoplatin and Docetaxel in Subjects With Prostate Cancer
Status: UNKNOWN
Conditions: Hormone Refractory Prostate Cancer
Interventions: DRUG: Picoplatin|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flibanserin in Men Receiving Androgen Suppression for Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Adenocarcinoma
Interventions: DRUG: Flibanserin 100 MG|DRUG: Placebo|DRUG: Androgen deprivation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Gleevec Idiopathic Hypereosinophilic Syndrome
Status: TERMINATED
Conditions: Eosinophilia|Hypereosinophilic Syndrome
Interventions: DRUG: Gleevec
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study for DC Vaccine in Recurrent or Progressive High-grade Gliomas
Status: RECRUITING
Conditions: WHO Grade III Gliomas|WHO Grade IV Gliomas
Interventions: BIOLOGICAL: personalized dendritic cell injection ZSNeo-DC1.1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Creatine and L-Arginine on Endothelial Function
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DIETARY_SUPPLEMENT: Creatine|DIETARY_SUPPLEMENT: L-arginine and creatine|DIETARY_SUPPLEMENT: l-arginine|DIETARY_SUPPLEMENT: placebo, double
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: CSD190601: A Study to Determine Subject Puffing Patterns of Electronic Nicotine Delivery Systems in an Ambulatory Setting
Status: COMPLETED
Conditions: Smoking|Smoking Behaviors|Tobacco Use|Tobacco Smoking
Interventions: OTHER: CSD190601-11|OTHER: CSD190601-12|OTHER: CSD190601-13|OTHER: CSD190601-14|OTHER: CSD190601-15|OTHER: CSD190601-16|OTHER: CSD190601-17|OTHER: CSD190601-21|OTHER: CSD190601-22|OTHER: CSD190601-23|OTHER: CSD190601-24|OTHER: CSD190601-25|OTHER: CSD190601-26|OTHER: CSD190601-27
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The CANTATA-M (CANagliflozin Treatment and Trial Analysis - Monotherapy) Trial
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Canagliflozin|DRUG: Placebo|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Extension of 2 mg/kg Pegunigalsidase Alfa (PRX-102) Every 4 Weeks in Adult Fabry Disease Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Fabry Disease
Interventions: DRUG: pegunigalsidase alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MK-8510 Monotherapy for the Treatment of Anti-retroviral naïve Human Immunodeficiency Virus Type 1 (HIV-1) Infected Participants (MK-8510-002)
Status: WITHDRAWN
Conditions: HIV-1|Human Immunodeficiency Virus 1|Immunodeficiency Virus Type 1, Human|Human Immunodeficiency Virus Type 1
Interventions: DRUG: MK-8510
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Clinical Evaluation of an Innovative Medical Device to Predict Preterm Birth (PrediMAP)
Status: RECRUITING
Conditions: Preterm Labor
Interventions: BIOLOGICAL: Collection of vaginal secretions|BIOLOGICAL: Collection of the placenta and the membranes|OTHER: Administration of EPDS questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetic and Safety Trial to Determine the Appropriate Dose for Pediatric Patients With Multidrug Resistant Tuberculosis
Status: COMPLETED
Conditions: Multidrug Resistant Tuberculosis|Pediatric
Interventions: DRUG: 100 mg Delamanid|DRUG: 50 mg Delamanid|DRUG: 25 mg Pediatric Formulation Delamanid|DRUG: 10 mg Delamanid Pediatric Formulation|DRUG: 5 mg Delamanid Pediatric Formulation|DRUG: Optimized Background Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Niclosamide in COVID-19
Status: WITHDRAWN
Conditions: Covid19
Interventions: DRUG: Niclosamide Oral Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SEVOflurane Inhalation in CARdiac Arrest Resuscitated Patients Treated With Therapeutic Hypothermia
Status: UNKNOWN
Conditions: Cardiac Arrest|Therapeutic Hypothermia
Interventions: DRUG: sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Health Effects of Passive Vape Among COPD Patients
Status: COMPLETED
Conditions: Electronic Cigarette Use|Second Hand Smoke|Lung Function
Interventions: OTHER: Passive vape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Interleukin-2 With or Without Histamine Dihydrochloride in Treating Patients With Stage IV Melanoma Metastatic to the Liver
Status: UNKNOWN
Conditions: Melanoma (Skin)|Metastatic Cancer
Interventions: BIOLOGICAL: aldesleukin|DRUG: histamine dihydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: rTMS-augmented Written Exposure Therapy for PTSD
Status: RECRUITING
Conditions: Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: Written Exposure Therapy|DEVICE: repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Standard of Care or Treatment on Protocol
Status: TERMINATED
Conditions: Stomach Cancer|Esophageal Cancer|Bladder Cancer|Skin Cancer|Lung Cancer|Uterine Cancer|Ovarian Cancer
Interventions: OTHER: standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Novel Skin Care for Immunotherapy- Related Dermatologic Toxicities
Status: RECRUITING
Conditions: Skin Toxicity|Immunotoxicity
Interventions: OTHER: Hydrating emollient + body lotion for immunotherapy-related side effects
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Safety and Efficacy of ZPL389 With TCS/TCI in Atopic Dermatitis Patients
Status: TERMINATED
Conditions: Atopic Dermatitis
Interventions: DRUG: ZPL389 30mg|DRUG: ZPL389 50mg|DRUG: TCS and/or TCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study to Evaluate the Efficacy and Safety of Ivacaftor and VX-661 in Combination With Ivacaftor in Subjects Aged 12 Years and Older With Cystic Fibrosis, Heterozygous for the F508del-cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mutation
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: VX-661/Ivacaftor|DRUG: Ivacaftor|DRUG: Placebo matched to VX-661/ ivacaftor|DRUG: Placebo matched to Ivacaftor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First-in-Human Phase I/II Study of FHND-9041 in Patients With EGFR Mutated Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer|EGFR Gene Mutation|EGFR-TKI Sensitizing Mutation
Interventions: DRUG: FHND-9041
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ahmed Glaucoma Valve Implantation; Graft-Free Short Tunnel Small Flap Versus Scleral Patch Graft
Status: UNKNOWN
Conditions: Glaucoma
Interventions: OTHER: Conventional scleral patch graft glaucoma implantation|OTHER: New surgical method (short tunnel small flap technique)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stool Transplant in Pediatric Patients With Recurring C. Difficile Infection
Status: COMPLETED
Conditions: Clostridium Difficile Colitis
Interventions: BIOLOGICAL: FMT|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Cytokine Adsorption as Additive Treatment of CAR-T Associated Cytokine Release Syndrome (CRS)
Status: UNKNOWN
Conditions: Cytokine Release Syndrome|CAR-T
Interventions: DEVICE: Cytosorb
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Double Blind, Safety and Immunogenicity Study of Recombinant Botulinum Vaccine A/B
Status: COMPLETED
Conditions: Botulism Vaccine
Interventions: BIOLOGICAL: Placebo (USP sterile saline for injection)|BIOLOGICAL: rBV A/B-40 vaccine|BIOLOGICAL: Placebo (USP sterile saline for injection)|BIOLOGICAL: rBV A/B-40 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Safety and Efficacy of Distal Embolic Protection Device in Vertebral Artery Origin Stenting
Status: UNKNOWN
Conditions: Adverse Event
Interventions: DEVICE: stenting with EPD|DEVICE: stent assisted angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Calaspargase Pegol or Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Adult B Acute Lymphoblastic Leukemia|Childhood B Acute Lymphoblastic Leukemia
Interventions: DRUG: Calaspargase Pegol-mknl|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Daunorubicin Hydrochloride|DRUG: Dexamethasone|DRUG: Doxorubicin Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Mercaptopurine|DRUG: Methotrexate|DRUG: Pegaspargase|OTHER: Pharmacological Study|DRUG: Prednisone|RADIATION: Radiation Therapy|DRUG: Thioguanine|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AZD9056 Relative Bioavailability Study
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD9056 formulation Phase III 50 mg (T)|DRUG: AZD9056 formulation Phase IIb 50 mg (R)|DRUG: AZD9056 formulation Phase III 200 mg (T)|DRUG: AZD9056 formulation Phase IIb 200mg (R)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Evaluation of a Folic Acid Wound Treatment (FAWT) for Chronic, Early-Stage Diabetic Foot Ulcer (DFU) Healing
Status: RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: COMBINATION_PRODUCT: Folinic acid calcium salt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Brain and Pelvic Floor Muscle Activity of Patients Who Had or Are Undergoing Robot-Assisted Radical Prostatectomy
Status: RECRUITING
Conditions: Prostate Carcinoma
Interventions: PROCEDURE: Electroencephalography|PROCEDURE: Electromyography|OTHER: Questionnaire Administration|PROCEDURE: Urodynamics (UDS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Corticosteroid Intralesional Injection as an Alternative Treatment in Oral Pyogenic Granuloma in the Esthetic Zone.
Status: UNKNOWN
Conditions: Oral Pyogenic Granuloma
Interventions: DRUG: Solu-Cortef
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate AZD2693 in Participants Who Are Carriers of the PNPLA3 148M Risk Allele With Non-cirrhotic Non-alcoholic Steatohepatitis With Fibrosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Nonalcoholic Steatohepatitis
Interventions: DRUG: AZD2693|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Glycerol as an Optical Clearing Agent for Visualization of the Middle Ear
Status: WITHDRAWN
Conditions: Tympanosclerosis|Thickened Ears|Healthy|Surgery
Interventions: DRUG: Glycerol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Preoperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy
Status: COMPLETED
Conditions: Pancreatic Cancer|Bile Duct Cancer
Interventions: DIETARY_SUPPLEMENT: Oral IMPACT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bilberry as a Dietary Supplement After Myocardial Infarction (The BEAR SMART Trial)
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DIETARY_SUPPLEMENT: Bilberry extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial Exploring the Ability of Negative Pressure Wound Therapy (NPWT) to Reduce Colorectal Surgical Site Infections (SSI)
Status: COMPLETED
Conditions: Surgical Wound Infection
Interventions: DEVICE: Prevena Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dual Antiplatelet Therapy Versus Oral Anticoagulation for a Short Time to Prevent Cerebral Embolism After TAVI
Status: COMPLETED
Conditions: Aortic Valve Stenosis|Stroke
Interventions: DRUG: aspirin+clopidogrel (Duoplavin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anxiety Surrounding Supracondylar Pin Removal in Children: A Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Supracondylar Humerus Fracture|Anxiety
Interventions: OTHER: Supracondylar Pin Removal Before Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-time Artificial Intelligence System for Detecting Multiple Ocular Fundus Lesions by Ultra-widefield Fundus Imaging
Status: UNKNOWN
Conditions: Artificial Intelligence|Diagnostic Imaging|Abnormality of the Fundus|Diagnostic Screening Programs
Interventions: DEVICE: Taking an ultra-widefield fundus image
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy Study of JNJ-64304500 in Participants With Moderately to Severely Active Crohn's Disease
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DRUG: JNJ-64304500|DRUG: Placebo|DRUG: Ustekinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of EGCG/Tocotrienol in 18 Patients With Splicing-mutation-mediated Cystic Fibrosis (CF)
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DIETARY_SUPPLEMENT: ECGC|DIETARY_SUPPLEMENT: Tocotrienol|DIETARY_SUPPLEMENT: EGCG + Tocotrienol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Stress Hyperglycemia in General and Vascular Surgery Patients
Status: RECRUITING
Conditions: Hyperglycemia Stress
Interventions: DRUG: Dulaglutide|DRUG: Placebo|DEVICE: Continuous glucose monitor (CGM), blinded
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Carboplatin-gemcitabine Versus Cisplatin- Gemcitabine as Neoadjuvant Chemotherapy for Treatment of Muscle Invasive Urinary Bladder Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Urinary Bladder Cancer
Interventions: DRUG: Carboplatin-Gemcitabine Cisplatin-Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Medical Management of Caries in the Primary Dentition Using Silver Nitrate
Status: COMPLETED
Conditions: Dental Caries
Interventions: PROCEDURE: Prophylaxis|DRUG: Fluoride varnish|DRUG: Silver Nitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FT522 With Rituximab in Relapsed/Refractory B-Cell Lymphoma (FT522-101)
Status: RECRUITING
Conditions: Relapsed/Refractory B-Cell Lymphoma
Interventions: DRUG: FT522|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ABI-H2158-containing Regimens in Participants With Chronic Hepatitis B Virus Infection
Status: TERMINATED
Conditions: Chronic Hepatitis B
Interventions: DRUG: ABI-H2158|DRUG: Placebo|DRUG: Entecavir (ETV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Physiology of Interregional Connectivity in the Human Brain
Status: UNKNOWN
Conditions: Healthy|Stroke|Traumatic Brain Injury|Multiple Sclerosis
Interventions: DEVICE: Single-pulse transcranial magnetic stimulation (spTMS)|DEVICE: Paired associative stimulation (PAS)|DEVICE: Repetitive transcranial magnetic stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase I/II Study to Investigate the Use of VORAXAZE™ as Intended Intervention in Patients With CNSL
Status: ACTIVE_NOT_RECRUITING
Conditions: CNS Lymphoma
Interventions: DRUG: Voraxaze Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Tolerability Study of ISOThrive Prebiotic Nectar (MIMO) in Subjects With Constipation
Status: COMPLETED
Conditions: Constipation
Interventions: DIETARY_SUPPLEMENT: ISOThrive Prebiotic Nectar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Mesenchymal Stem Cell Secretome In Severe Cases of COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Injection of secretome - mesenchymal stem cell|OTHER: Placebo|DRUG: Standard treatment of Covid-19
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fasting Study of Alendronate Sodium Tablets (70 mg) and Fosamax Tablets (70 mg)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Alendronate Sodium Tablets, 70 mg|DRUG: Fosamax Tablets, 70 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: T790M Mutation on ctDNA in Patients With NSCLC After EGFR-TKI Failure
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer Stage III|Non-Small-Cell Lung Cancer Metastatic
Interventions: OTHER: mutation detection|OTHER: ARMS and ddPCR|GENETIC: ctDNA analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Assessment of Itraconazole Self Nano Emulsifying Drug Delivery System Intermediate Gel
Status: COMPLETED
Conditions: Tinea Versicolor
Interventions: DRUG: itraconazole gel once daily|DRUG: itraconazole gel twice daily|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Randomized Prospective Trial on the Occurrence of Laparoscopic Trocar Site Hernias
Status: COMPLETED
Conditions: The Aim of the Study is to Analyze the Incidence of Trocar Site Hernia (TSH)|in Orifices Created by Trocars Measuring ≥10 mm in Diameter,|and to Determine Whether Closure of the External Fascial Layer Prevents|TSH and Potential Related Complications.
Interventions: PROCEDURE: Trocar site closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Investigate the Safety, Tolerability and Pharmacokinetics of TB-840 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Comparison of TB-840 treatment with Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of The Relationship Between Perioperative Hypothermia and Emergence Agitation
Status: RECRUITING
Conditions: Hypothermia; Anesthesia|Agitation, Emergence|Postoperative Complications|Hypothermia Following Anesthesia
Interventions: PROCEDURE: surgery|PROCEDURE: sedation scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Implementation of REFOCUS Training Program in Mental Health Services
Status: RECRUITING
Conditions: Mental Disorders
Interventions: OTHER: Implementation of a training centered around the notions of recovery with mental health services first year|OTHER: Implementation of a training centered around the notions of recovery with mental health services second year
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Aneurysmal Subarachnoid Hemorrhage Trial RandOmizing Heparin
Status: SUSPENDED
Conditions: Aneurysmal Subarachnoid Hemorrhage|Neurobehavioral Manifestations|Vasospasm, Intracranial|Intracranial Aneurysm|Heparin-induced Thrombocytopenia Type II
Interventions: DRUG: Continuous Low-Dose IV Unfractionated Heparin Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyperoxia and Microvascular Dysfunction
Status: TERMINATED
Conditions: Coronary Microvascular Disease|Microvascular Disease|Ischemic Heart Disease
Interventions: OTHER: Hyperoxia|OTHER: Normoxia|DEVICE: laser Doppler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Pembrolizumab Given With Ipilimumab or Placebo in Participants With Untreated Metastatic Non-Small Cell Lung Cancer (NSCLC) (MK-3475-598/KEYNOTE-598)
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Ipilimumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - SAfety & EffectiveneSS of Drug-ElUting Stents & Anti-platelet REgimen
Status: UNKNOWN
Conditions: Coronary Heart Disease
Interventions: DEVICE: Everolimus-eluting coronary stenting system (EECSS, Promus Element)|DEVICE: Zotarolimus-eluting coronary stenting system (ZECSS, Endeavor Resolute)|DRUG: Triple anti-platelet therapy (TAT)|DRUG: Double-dose clopidogrel anti-platelet therapy (DDAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intradialytic Parenteral Nutrition on Morbidity and Mortality of Malnourished Hemodialysis Patients
Status: TERMINATED
Conditions: Hemodialysis|Malnutrition
Interventions: DRUG: Intradialytic parenteral nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mulberry Leaf Extract and Blood Glucose Control in Diabetics
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DIETARY_SUPPLEMENT: Mulberry leaf extract effect on post prandial blood glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SMP vs RIRS for Symptomatic Lower Pole Renal Calculi of 10-20 mm Size: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Renal Calculi
Interventions: PROCEDURE: Super-Mini Percutaneous Nephrolithotomy|PROCEDURE: Retrograde Intrarenal Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Automatic Oxygen Flow Titration During Walking in Patients With COPD
Status: COMPLETED
Conditions: COPD|Exercise|Endurance Shuttle Walking Test (Exercise at 85% of Maximal Shuttle Walking Test)
Interventions: DEVICE: Automated oxygen titration|DRUG: Compressed air|DRUG: Oxygen constant flow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transversus Abdominis Plane Blocks With and Without Dexamethasone
Status: RECRUITING
Conditions: Colorectal Disorders|Regional Anesthesia Morbidity|Analgesia|Local Anesthetic Complication|Pain, Postoperative|Colorectal Cancer|Crohn Disease|Diverticular Diseases
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Acute Heart Failure Patients With High Copeptin Treated With Tolvaptan Targets Increased AVP Activation for Treatment (ACTIVATE)
Status: UNKNOWN
Conditions: Acute Heart Failure
Interventions: DRUG: Tolvaptan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of Ragweed SLIT Tablets
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal|Ragweed Pollen Allergy
Interventions: DRUG: Sublingual tablet of ragweed pollen allergen extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Probiotics on Gingivitis: Part 2
Status: COMPLETED
Conditions: Gingivitis; Chronic
Interventions: DIETARY_SUPPLEMENT: Dentoblis|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Candida Rugosa Lipase on Serum Triglyceride Lowering
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Candida cylindracea lipase (225,000 FIP lipase units per day)|DIETARY_SUPPLEMENT: Candida cylindracea lipase (450,000 FIP lipase units per day)|DIETARY_SUPPLEMENT: Candida cylindracea lipase (675,000 FIP lipase units per day)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Insertion of Immediate Cortical Satellite Implants With Immediate Loading
Status: NOT_YET_RECRUITING
Conditions: Immediate Loading , Satellite Implant , Immediate Implant
Interventions: DEVICE: immediate satellite implant with immediate loading
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study To Assess the Safety and Tolerability of Single Ascending Oral Doses of PBF-999 in Healthy Young Male Volunteers
Status: COMPLETED
Conditions: Huntington's Disease
Interventions: DRUG: PBF-999|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SPHERIC-1. Sildenafil and Pulmonary HypERtension In COPD
Status: UNKNOWN
Conditions: Pulmonary Hypertension|COPD
Interventions: DRUG: Sildenafil citrate|DRUG: Sugar pills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Fingolimod (FTY720) in Patients With Relapsing-remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Fingolimod|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Cryoballoon Ablation as Initial Treatment for Persistent Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation, Persistent|Arrhythmias, Cardiac
Interventions: DRUG: Antiarrhythmic drug including Propafenone, Sotalol, Dronedarone and Amiodarone|DEVICE: cryoballoon ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Sintilimab Combined With Chemotherapy for Neoadjuvant Treatment of Esophageal Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Endometrial Cancer, Fallopian Tube Cancer, or Sarcoma of the Female Reproductive Tract
Status: COMPLETED
Conditions: Endometrial Cancer|Fallopian Tube Cancer|Ovarian Cancer|Sarcoma
Interventions: DRUG: paclitaxel|DRUG: pegylated liposomal doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Study of Ablation Pursuing Atrial Fibrillation Termination as a Procedural Endpoint in Patients With Persistent Atrial Fibrillation
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation|Cathter Ablation|Endpoint
Interventions: PROCEDURE: AF-termination Group|PROCEDURE: Prespecified-ablation Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Microvascular Breast Reconstruction With Lymph Node Transfer
Status: WITHDRAWN
Conditions: Lymphedema|Lymphedema of Upper Arm|Mastectomy; Lymphedema
Interventions: PROCEDURE: Microvascular Breast Reconstruction with Vascularized Lymph Node Transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2a Study to Assess Safety, Daily Symptoms, PK, and Biomarkers of YPL-001 in COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: YPL-001 80 mg|DRUG: YPL-001 160 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Effectiveness and Safety of a New Medication in the Treatment of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Lurasidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Flurbiprofen 8.75 mg Lozenge in Patient With Pharyngitis
Status: COMPLETED
Conditions: Pharyngitis
Interventions: DRUG: Placebo|DRUG: Flurbiprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of IV Ketamine for Emergency Department Treatment of Adolescent Suicidal Ideation
Status: RECRUITING
Conditions: Suicidal Ideation|Suicidal Ideas
Interventions: DRUG: Ketamine Hydrochloride|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proxalutamide Treatment for COVID-19 Female Outpatients
Status: WITHDRAWN
Conditions: Covid19|SARS-CoV Infection
Interventions: DRUG: Proxalutamide|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tegoprazan on Pharmacodynamics of Clopidogrel in Healthy Subjects
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DRUG: Clopidogrel 75 mg|DRUG: Tegoprazan 25 mg|DRUG: Esomeprazole 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Guelph Family Health Study: Pilot Study
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Emails and 4 Home Visits|BEHAVIORAL: Control|BEHAVIORAL: Emails and 2 home visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Osimertinib Therapy After Resection in High-risk Stage I EGFRm NSCLC (OSTAR)
Status: RECRUITING
Conditions: NSCLC, Stage I
Interventions: DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STI571 Plus Cytarabine in Treating Patients With Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Blastic Phase Chronic Myelogenous Leukemia|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Relapsing Chronic Myelogenous Leukemia
Interventions: DRUG: imatinib mesylate|DRUG: cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Human Erythropoietin Use in Intensive Care Unit (ICU) Patients: Does it Prevent Acute Renal Failure
Status: COMPLETED
Conditions: Acute Renal Failure
Interventions: DRUG: epoetinum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maintaining Skin Integrity in Neonates With Sunflower Seed Oil and Liquid Vaseline
Status: COMPLETED
Conditions: Neonatal Skin Conditions|Nursing Caries
Interventions: OTHER: Moisturizing with SSO|OTHER: Moisturizing with LV|OTHER: The control group was not moisturized.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Ganglion Sphenopalatine Block Versus Placebo on Persistent Headache Following COVID-19 Infection
Status: TERMINATED
Conditions: Headache|Covid19|Sphenopalatine Ganglion Block|Persistent Headache Following COVID-19
Interventions: PROCEDURE: Sphenopalatine Ganglion Block with Local Anesthetic|PROCEDURE: Sphenopalatine Ganglion Block with Placebo (Isotone NaCl)|PROCEDURE: "Sham"-block with Placebo (Isotone NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Antihypertensive Exposure and Adverse Metabolic Effects: PEAR Follow-Up Study
Status: COMPLETED
Conditions: Drug Induced Hyperglycemia|Secondary Hyperlipidemia
Interventions: DRUG: Oral Glucose Tolerance Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Stereotactic Body Radiation Therapy and Durvalumab With or Without Tremelimumab Before Surgery in Treating Participants With Human Papillomavirus Positive Oropharyngeal Squamous Cell Caner
Status: TERMINATED
Conditions: Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC (American Joint Committee on Cancer) v8|Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Human Papillomavirus Positive|Oropharyngeal Squamous Cell Carcinoma|p16 Positive Neoplastic Cells Present|Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
Interventions: BIOLOGICAL: Durvalumab|PROCEDURE: Modified Radical Neck Dissection|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Stereotactic Body Radiation Therapy|PROCEDURE: Transoral Robotic Surgery|BIOLOGICAL: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin C Supplementation Plus Hypoglycemic Agents Versus Hypoglycemic Agents Alone in Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Vitamin C|DRUG: glyburide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: OMEGA-Study: Effect of Omega 3-Fatty Acids on the Reduction of Sudden Cardiac Death After Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: Zodin (drug)|DRUG: Olive oil (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Radiographic Evaluation of NIPSA Versus M-MIST in Treatment of Intra-osseous Defects
Status: UNKNOWN
Conditions: Periodontitis, Adult
Interventions: PROCEDURE: Group A (Test): Patients will receive NIPSA|PROCEDURE: Group B (Control): Patients will receive M-MIST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Stepwise Strategy Utilizing Buprenorphine and Methadone
Status: COMPLETED
Conditions: Heroin Dependence
Interventions: DRUG: methadone|DRUG: buprenorphine / methadone sequence|BEHAVIORAL: Relapse prevention|BEHAVIORAL: Contingency management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: 18F-F-AraG PET Imaging to Evaluate Immunological Response to CAR T Cell Therapy in Lymphoma
Status: RECRUITING
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: [ 18F]F-AraG PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy Study of Cenobamate in Pediatric Subjects 2-17 Years of Age With Partial-onset (Focal) Seizures
Status: RECRUITING
Conditions: Partial Epilepsy
Interventions: DRUG: Xcopri
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Artificial Sweeteners or Sugar on Hemodynamic and Metabolic Stress Responses
Status: COMPLETED
Conditions: Normal Subjects
Interventions: OTHER: Ingestion of artificially-sweetened beverages|OTHER: Ingestion of sugar-sweetened beverages|OTHER: Ingestion of water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vigabatrin Ph 1 Cocaine Interaction Study
Status: COMPLETED
Conditions: Cocaine Addiction
Interventions: DRUG: Vigabatrin|DRUG: Vigabatrin|DRUG: Vigabatrin|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mechanisms of Immune Reconstitution & Reduced Immune Activation Following Darunavir-based ART
Status: COMPLETED
Conditions: Human Immunodeficiency Virus Infection
Interventions: DRUG: darunavir with ritonavir and fixed-dose viread+emtricitabine daily
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AZD4635 Relative Bioavailability Study
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: AZD4635 50 mg nano-suspension (reference)|DRUG: AZD4635 solid oral formulation - fasted|DRUG: AZD4635 solid oral formulation - fed|DRUG: Lansoprazole and AZD4635 50 mg solid oral formulation|DRUG: AZD4635 solid oral formulation variant 1 - fasted|DRUG: AZD4635 solid oral formulation variant 2 - fasted|DRUG: [14C] AZD4635 IV microtracer - fasted
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: CLOZAPINE Response in Biotype-1
Status: RECRUITING
Conditions: Schizophrenia|Schizoaffective Disorder|Bipolar 1 Disorder
Interventions: DRUG: clozapine|DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Magnetic Imaging to Asses the Efficacy of Cap Assisted Colonoscopy in Reducing Looping and Improving Patient Acceptance for the Colonoscopy Procedure
Status: WITHDRAWN
Conditions: Colonoscopy
Interventions: PROCEDURE: MEI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC