pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Alberta Back Care Pathway (ABCp) - Edmonton West Primary Care Network (EWPCN) & Alberta Health Services' Calgary Chronic Pain Centre (CPC)
Status: RECRUITING
Conditions: Low Back Pain
Interventions: OTHER: ABCp|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Treatment With MPC-7869 for Patients With Alzheimer's Who Previously Participated in an MPC-7869 Protocol
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: MPC-7869
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Perioperative Intravenous Lidocaine Infusion and Magnesium Infusion on the Functional Recovery After General Anesthesia in the Patients Undergoing Thyroid Surgery
Status: COMPLETED
Conditions: Thyroid Cancer
Interventions: DRUG: Lidocaine|DRUG: Magnesium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Safety and Efficacy of Econazole Nitrate Foam 1% in Subjects With Tinea Pedis
Status: COMPLETED
Conditions: Tinea Pedis|Athlete's Foot
Interventions: DRUG: Econazole Nitrate Foam 1%|OTHER: Vehicle Foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Survivorship Promotion In Reducing IGF-1 Trial
Status: COMPLETED
Conditions: Breast Cancer|Prostate Cancer|Lung Cancer|Colon Cancer|Melanoma of Skin|Endometrial Cancer|Liver Cancer|Pancreatic Cancer|Rectal Cancer|Kidney Cancer|Other Solid Malignant Tumors
Interventions: DRUG: Metformin|BEHAVIORAL: Coach Directed Behavioral Weight Loss|BEHAVIORAL: Self-control weight loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Gefapixant (MK-7264) in Women With Chronic Cough and Stress Urinary Incontinence (MK-7264-042)
Status: COMPLETED
Conditions: Chronic Cough
Interventions: DRUG: Gefapixant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial Evaluating an Organ-conserving Strategy by Radiochemotherapy for Muscle-infiltrative Bladder Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Infiltrating Bladder Urothelial Carcinoma
Interventions: OTHER: Radiation + cisplatin|OTHER: Radiation + cisplatin + gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cilengitide and Metronomic Temozolomide for Relapsed or Refractory High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas in Children and Adolescents
Status: TERMINATED
Conditions: Gliomas
Interventions: DRUG: Cilengitide|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donepezil Compared to Placebo in Patients With Chronic Neuropathic Pain
Status: TERMINATED
Conditions: Neuropathic Pain
Interventions: DRUG: Donepezil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cholecystokinin for Reducing Binge Eating in People With Bulimia Nervosa
Status: TERMINATED
Conditions: Bulimia Nervosa|Eating Disorders
Interventions: PROCEDURE: Cholecystokinin (CCK) infusion|PROCEDURE: Saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dexamethasone Versus Demedetomidine Addition for Adductor Canal Block
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Dexmedetomidine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Polytetrafluoroethylen (PTFE) Vascular Prostheses With Heparin Bonded Luminal Surfaces vs Crude ePTFE
Status: COMPLETED
Conditions: Ischemia Lesions
Interventions: PROCEDURE: revascularization|DEVICE: Propaten®|DEVICE: Crude PTFE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Sensory Effects of Oral Opioid Treatment in Patients With Chronic Low Back Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Low Back Pain
Interventions: DRUG: Oxycodone or morphine sulfate immediate release (MSIR)|DRUG: Placebo Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: EXtending the Time Window for Thrombolysis in Posterior Circulation Stroke Without Early CT Signs
Status: COMPLETED
Conditions: Stroke, Acute Ischemic
Interventions: DRUG: Tissue Plasminogen Activator (Alteplase)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comorbid Insomnia and Sleep Disordered Breathing in Patients Undergoing Cardiac Rehabilitation
Status: COMPLETED
Conditions: Coronary Artery Disease|Sleep Disorder; Breathing-Related|Sleep Disorder; Insomnia Type
Interventions: DIAGNOSTIC_TEST: Polysomnograpy|DIAGNOSTIC_TEST: actigraphy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Radiologic Pathologic Correlation of Advanced MR Imaging to Guide the Biopsy of Cerebral Malignancies
Status: RECRUITING
Conditions: Brain Lesion
Interventions: PROCEDURE: Advanced Magnetic Resonance Imaging Scan|PROCEDURE: Standard of Care Brain Biopsy and Tumor Removal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: OAR-Based, Dose Escalated SBRT With Real Time Adaptive MRI Guidance for Liver Metastases
Status: SUSPENDED
Conditions: Liver Metastases|Stereotactic Body Radiation Therapy|MRI-guided Treatment
Interventions: RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Whole Mesh and Split Mesh Use in Laparoscopic Inguinal Hernia Repair
Status: UNKNOWN
Conditions: Hernia, Inguinal
Interventions: PROCEDURE: Split Mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multicentre RCT of Awake Versus Asleep Tractography Based DBS for ET
Status: RECRUITING
Conditions: Essential Tremor|Deep Brain Stimulation|Diffusion Tensor Imaging|Magnetic Resonance|Central Nervous System Diseases
Interventions: PROCEDURE: Awake DBS|PROCEDURE: Asleep DBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Gadobutrol 1.0 Molar (Gadovist) for Breast MRI
Status: COMPLETED
Conditions: Breast Cancer|Diagnostic Imaging
Interventions: DRUG: Gadobutrol (Gadavist, Gadovist, BAY86-4875)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence Study of Lopinavir/Ritonavir 200/50 mg Film Tablet (World Medicine Ilac, Turkey) Under Fasting Conditions
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Lopinavir/Ritonavir 200 mg/50 mg Film Tablet|DRUG: Lopinavir/Ritonavir 200 mg/50 mg Film Coated Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase 3 Study of 10-valent Pneumococcal Conjugate Vaccine (PNEUMOSIL) in Healthy Infants
Status: COMPLETED
Conditions: Pneumonia, Pneumococcal
Interventions: BIOLOGICAL: Pneumosil|BIOLOGICAL: Synflorix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Laparoscope Anatomical and Aon-anatomical Hepatectomy
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: Laparoscopic Anatomical Hepatectomy|PROCEDURE: Laparoscopic Aon-anatomical Hepatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevail-Us: A Study Of Pitavastatin 4 mg Vs. Pravastatin 40 mg In Patients With Primary Hyperlipidemia Or Mixed Dyslipidemia
Status: COMPLETED
Conditions: Primary Dyslipidemia|Mixed Dyslipidemia
Interventions: DRUG: pitavastatin|DRUG: pravastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Tofacitinib in Early Diffuse Cutaneous Systemic Sclerosis (dcSSc)
Status: COMPLETED
Conditions: Systemic Sclerosis|Scleroderma
Interventions: DRUG: Tofacitinib|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Pharmacokinetics Study of CPL207280 After 2-weeks Administration in Subjects With Type 2 Diabetes
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: CPL207280|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Feasibility and Implementation of Whole Genome Sequencing in Patients With Suspected Genetic Disorder
Status: COMPLETED
Conditions: Hereditary Disease|Genetic Predisposition to Disease
Interventions: GENETIC: Whole Genome Sequencing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate Zilucoplan Injected Subcutaneously Either by a Prefilled Syringe or an Auto-injector in Healthy Adult Participants
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: Zilucoplan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Optical Coherence Tomography Angiography Microvascular Changes in Primary Open Angle and Primary Angle Closure Glaucoma
Status: COMPLETED
Conditions: Glaucoma,Primary Open-Angle ,Primary Angle Closure
Interventions: DEVICE: Optical coherence tomography angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Varlitinib Plus Capecitabine in Chinese Patients With Advanced or Metastatic Biliary Tract Cancer
Status: COMPLETED
Conditions: Biliary Tract Cancer
Interventions: DRUG: Varlitinib|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Multicenter Trial of Early Versus Late Drain Removal After Pancreaticoduodenectomy
Status: COMPLETED
Conditions: Pancreaticoduodenectomy|Drainage
Interventions: OTHER: Early drain removal|OTHER: Late drain removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Yield of Post PRandial Esophageal High Resolution Impedance Manometry in Patients With Gastro-Esophageal Reflux Disease Symptoms Resistant to Proton Pump Inhibitor Therapy
Status: RECRUITING
Conditions: Gastro-esophageal Reflux Disease
Interventions: PROCEDURE: Upper gastrointestinal (GI) endoscopy|PROCEDURE: Wireless pH monitoring|PROCEDURE: Post prandial esophageal High Resolution Impedance Manometry|PROCEDURE: pH-impedance monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: QuantiFERON-CMV Test in a Prediction for Colic Cytomegalovirus Reactivation During Ulcerative Colitis
Status: RECRUITING
Conditions: Cytomegalovirus Infections
Interventions: PROCEDURE: Biopsies|BIOLOGICAL: Blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Outcome of Combined Partial Fistulectomy or Fistulotomy and Cutting Seton Procedure in High Perianal Fistula
Status: UNKNOWN
Conditions: High Anal Fistula
Interventions: PROCEDURE: combined partial fistulectomy or fistulotomy and cutting seton procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexibuprofen 400 mg Sachet Versus Ibuprofen 400 mg Sachet in Patients With Osteoarthritis of the Hip or Knee
Status: COMPLETED
Conditions: Osteoarthritis of the Hip or Knee
Interventions: DRUG: Dexibuprofen|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allo BMT Using Matched Related/Unrelated Donors With FluBu and HiCY
Status: COMPLETED
Conditions: Lymphoma|Multiple Myeloma|Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: Busulfan, Fludarabine, Cytoxan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7565020 in Healthy Participants and in Participants With Chronic Hepatitis B Virus Infection
Status: RECRUITING
Conditions: Chronic Hepatitis B
Interventions: DRUG: RO7565020|OTHER: Placebo|DRUG: Nucleos(t)ide analogue (NUC) treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence of Lactose Intolerance Among Self-reported Lactose Intolerant People
Status: COMPLETED
Conditions: Lactose Intolerance
Interventions: DIETARY_SUPPLEMENT: Oral consumption of milk with sequence A1-A2|DIETARY_SUPPLEMENT: Oral consumption of milk with sequence A2-A1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination of Metformine/Inulin Versus Metformin on Prostate Benign Hyperplasia in Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DRUG: Metformin|DIETARY_SUPPLEMENT: Agave inulin|OTHER: Placebo of agave inulin|OTHER: Metformin placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mycophenolate Mofetil Immunosuppression Without/With Reduced Dose Calcineurin Inhibitor Long After Liver Transplantation
Status: COMPLETED
Conditions: Liver Disease
Interventions: DRUG: mycophenolate mofetil|DRUG: mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Post-Extubation Laryngeal Edema With Intravenous Corticosteroids
Status: COMPLETED
Conditions: Post-Extubation Laryngeal Edema
Interventions: DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Effect of Solius UV Light Source in Improving Vitamin D Status
Status: COMPLETED
Conditions: Vitamin D Deficiency|Vitamin D Insufficiency
Interventions: DEVICE: UVB treatment|DEVICE: Sham comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MRI and Mammography Before Surgery in Patients With Stage I-II Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Estrogen Receptor-negative Breast Cancer|Progesterone Receptor-negative Breast Cancer|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage II Breast Cancer|Triple-negative Breast Cancer
Interventions: PROCEDURE: Breast surgery|PROCEDURE: Magnetic resonance imaging|PROCEDURE: Mammography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate Combination Treatment of MGCD0103 and Docetaxel (Taxotere®) for Subjects With Advanced Cancer Tumors
Status: TERMINATED
Conditions: Breast Cancer|Lung Cancer|Pulmonary Cancer|Non-Small-Cell Lung Carcinoma|Prostate Cancer|Prostatic Cancer|Gastric Cancer|Stomach Cancer
Interventions: DRUG: MGCD0103 & Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bimodal and Coaxial High Resolution Ophtalmic Imaging
Status: RECRUITING
Conditions: Retinitis Pigmentosa|Maculopathy, Age Related|Macular Dystrophy|Macular Edema|Retinal Detachment|Retinal Degeneration|Glaucoma|Vascular Inflammation|Hypertension|Stroke|Diabetes
Interventions: OTHER: Bimodal high resolution imaging of the retina
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Preliminary Efficacy of BGP345A in Constipation Due to Opioid-based Medications
Status: RECRUITING
Conditions: Opioid-Induced Constipation
Interventions: BIOLOGICAL: Lactobacillus gasseri BGP345A|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Venetoclax in Combination With Chemotherapy to Treat Newly Diagnosed Acute Lymphoblastic Leukemia (ALL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metabolomics Initiative: Mediterranean-amplified vs Habitual Western Diet on Food Signatures, Health, and Microbiome
Status: ACTIVE_NOT_RECRUITING
Conditions: Dietary Habits
Interventions: OTHER: Semi-controlled dietary intervention - Western|OTHER: Semi-controlled dietary intervention - MiniMed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy Study of RX-10100 to Treat Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Major Depressive Disorder (MDD)
Interventions: DRUG: RX-10100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Estimate The Relative Bioavailability Of PF-00258210 Administered Alone Or In Combination With PF-00610355
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Treatment A|DRUG: Treatment B|DRUG: Treatment C|DRUG: Treatment D|DRUG: Treatment E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sintilimab (PD-1 Antibody) and Chemoradiotherapy in Locoregionally-advanced Nasopharyngeal Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Nasopharyngeal Neoplasms
Interventions: DRUG: Sintilimab|DRUG: Gemcitabine|DRUG: Cisplatin|RADIATION: intensity-modulated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of School-Based, Peer-Led Asthma and Smoking Prevention Program on CO1 Levels and Smoking Behavior Among Early Adolescents in Jordan
Status: COMPLETED
Conditions: Asthma|Tobacco|Waterpipe|Cigarettes
Interventions: BEHAVIORAL: TAJ Plus (Adolescent Asthma Action in Jordan) Plus the added class smoke free pledge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Cardiac Arrhythmias in Epilepsy: the CARELINK-study
Status: COMPLETED
Conditions: Epilepsy|Asystole|Cardiac Arrhythmias
Interventions: DEVICE: implantable heart rate monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effectiveness of Blastocentesis Versus Trophectoderm Biopsy
Status: UNKNOWN
Conditions: Abnormal Karyotype
Interventions: PROCEDURE: Blastocentisis|PROCEDURE: Trophectoderm biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Influence of Low Energy Availability on Skeletal Muscle and Cardiovascular Health
Status: COMPLETED
Conditions: Diet; Deficiency|Exercise Intervention
Interventions: OTHER: Diet intervention - caloric restriction|OTHER: Exercise intervention|OTHER: Diet intervention - Energy balance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Severe COVID-19 Patients Using Secretome of Hypoxia-Mesenchymal Stem Cells in Indonesia
Status: UNKNOWN
Conditions: Covid-19|Cytokine Storm
Interventions: BIOLOGICAL: Injection of Secretome-MSCs|DRUG: Standard treatment of Covid-19
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Pentosan Polysulfate Sodium twice weekly|DRUG: Placebo (Sodium Chloride Injection, 0.9%)|DRUG: Pentosan Polysulfate Sodium Fixed Dose|DRUG: Pentosan Polysulfate Sodium once weekly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Medical Nutritional Supplements
Status: COMPLETED
Conditions: Elderly
Interventions: OTHER: Oral medical nutritional supplement|OTHER: Experimental oral medical nutritional supplement with AN777
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EEG Cap for Identification of Non-Convulsive Status Epilepticus
Status: COMPLETED
Conditions: Nonconvulsive Status Epilepticus|Subclinical Seizure|Altered Mental Status|Nonepileptic Seizures|Encephalopathy
Interventions: DEVICE: EEG Cap|DRUG: Anti-seizure medication|PROCEDURE: Standard EEG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Omega-3 Fatty Acids and Menaquinone-7 on Thrombotic Tendency
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DIETARY_SUPPLEMENT: menaquinone-7|DIETARY_SUPPLEMENT: fish oil|DIETARY_SUPPLEMENT: krill oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Decision Making and Implementation of Aging-in-Place/Long Term Care Plans Among Older Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer Disease|Mild Cognitive Impairment
Interventions: BEHAVIORAL: PlanYourLifespan.org
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Measuring Molecular Residual Disease in Colorectal Cancer After Primary Surgery and Resection of Metastases
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer|Residual Disease
Interventions: DIAGNOSTIC_TEST: blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Patient Satisfaction With GLASH VISTA™ (Bimatoprost 0.03%) in the Treatment of Eyelash Hypotrichosis in Japan
Status: COMPLETED
Conditions: Eyelash Hypotrichosis
Interventions: DRUG: Bimatoprost cutaneous solution 0.03%
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Age-Related Eye Disease Study 2 (AREDS2)
Status: COMPLETED
Conditions: Age-related Macular Degeneration|Cataract
Interventions: DIETARY_SUPPLEMENT: Lutein/zeaxanthin|DIETARY_SUPPLEMENT: DHA/EPA|DRUG: Lutein/zeaxanthin and DHA/EPA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Robotic vs. Conventional Minimal-invasive Inguinal Hernia Repair
Status: UNKNOWN
Conditions: Hernia, Inguinal|Robotic Surgical Procedures
Interventions: PROCEDURE: TEP|PROCEDURE: rTAPP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of an Innovative Non-contact Optical Device for Skin Oxygenation Imaging
Status: NOT_YET_RECRUITING
Conditions: Chronic Wounds|Obliterating Arteriopathy of the Lower Limbs
Interventions: DEVICE: Oxygen saturation measurement using the IPAM device|DEVICE: Transcutaneous oxygen partial pressure (TcPO2) using the PeriFlux6000 device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: EUS Ductal Evaluation in One Endoscopic Session for the Diagnosis of Exocrine Pancreas Disease
Status: COMPLETED
Conditions: Pancreatic Disease
Interventions: PROCEDURE: Combined EUS, e-PFT and sEUS Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Diaphragm Thickness by Ultrasonography in Neurological Disorders
Status: COMPLETED
Conditions: Guillain-Barre Syndrome|Myasthenia Gravis
Interventions: RADIATION: diaphragmatic ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study of Cardiac PET/CT Imaging to Guide Ablation Treatment of Ventricular Tachycardia
Status: ENROLLING_BY_INVITATION
Conditions: Ventricular Tachycardia
Interventions: DRUG: [C-11] Meta-hydroxyephedrine radioactive tracer (MHED)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Reporting of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor Inhibitors Associated Cardiovascular Adverse reactioN.
Status: COMPLETED
Conditions: Cardiac Complication|Vascular Diseases
Interventions: DRUG: Cardiac complication induced by VEGF/VEGFR inhibitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Consolidation Treatment With Ponatinib 15 mg on Treatment Free-Remission Rate in Patients With Chronic Myeloid Leukemia
Status: UNKNOWN
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Ponatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial With Quetiapine Prophylaxis Postoperative Delirium in High Risk Surgical Patients
Status: TERMINATED
Conditions: Postoperative Delirium
Interventions: DRUG: Quetiapine 25 milligrams capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Testing if Reductions in Negative Affect Yield Decreased Emotional Eating Symptoms
Status: TERMINATED
Conditions: Eating Disorder Symptom|Emotional Maladjustment|Negative Thoughts
Interventions: BEHAVIORAL: Cognitive Bias Treatment|BEHAVIORAL: Relaxation Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Antipsychotic Combination With Psychosocial Intervention on Outcome of Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Chlorpromazine, Sulpiride, Clozapine, Olanzapine, Risperidone, Quetiapine, Aripitrazole|BEHAVIORAL: psychosocial intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Compare the Efficacy of Surgery Followed by Sunitinib With Surgery Followed by Imatinib in GIST Patients With Progression on Imatinib.
Status: UNKNOWN
Conditions: GIST
Interventions: DRUG: Imatinib 400mg|DRUG: Sunitinib 37.5Mg Oral Capsule
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mode of Exercise and Bone Biomarkers in Older Veterans
Status: RECRUITING
Conditions: Aging|Musculoskeletal Diseases|Osteoporosis
Interventions: BEHAVIORAL: 10 Weeks of Supervised Resistance Exercise Training|BEHAVIORAL: 10 Weeks of Supervised Endurance Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effects of Equivalent Weight Loss With or Without Exercise Training on Breast Cancer Risk (SHAPE-2)
Status: COMPLETED
Conditions: Breast Cancer Risk
Interventions: BEHAVIORAL: Diet|BEHAVIORAL: Mainly exercise induced weight loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mental and Physical Well-Being of Frontline Health Care Workers During Coronavirus Disease 2019 (COVID-19)
Status: COMPLETED
Conditions: Healthy
Interventions: BEHAVIORAL: Stress First Aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Trial to Describe the Safety and Immunogenicity of MenABCWY When Administered on 2 Schedules
Status: COMPLETED
Conditions: Meningococcal Vaccine
Interventions: BIOLOGICAL: MenABCWY|BIOLOGICAL: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of a Fortified Dietary Supplement for Pregnant Women on Maternal and Newborn Outcomes in Kampong Chhnang Province, Cambodia
Status: COMPLETED
Conditions: Maternal and Newborn Health
Interventions: DIETARY_SUPPLEMENT: Corn Soya Blend+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Gabapentin Treatment of Cannabis Dependence
Status: COMPLETED
Conditions: Cannabis Dependence|Cannabis Withdrawal|Cognitive Deficits
Interventions: DRUG: gabapentin 1200mg/day|DRUG: Placebo|BEHAVIORAL: Manual-guided behavioral counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Agents Intervening Against Delirium in Intensive Care Unit
Status: ACTIVE_NOT_RECRUITING
Conditions: Delirium
Interventions: DRUG: Haloperidol Injection|OTHER: Saline (0,9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled Hypertonic Saline for Bronchiolitis
Status: WITHDRAWN
Conditions: Bronchiolitis
Interventions: OTHER: inhaled 7% hypertonic saline|OTHER: inhaled nebulized normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Investigate Safety, Tolerability, and Pharmacokinetics of CK-0045 in Healthy Participants and Otherwise Healthy Participants With Obesity
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CK-0045|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy and Safety of Iloperidone in the Acute Treatment of Manic or Mixed Episodes Associated With Bipolar I Disorder
Status: COMPLETED
Conditions: Bipolar I Disorder
Interventions: DRUG: Iloperidone|DRUG: Iloperidone Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of CTPT Method in the Treatment of Post Stroke Shoulder Subluxation
Status: COMPLETED
Conditions: Subluxation of Inferior Shoulder
Interventions: OTHER: conventional neuro rehabilitation programme|OTHER: California tri-pull taping (CTPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Increasing Smoking Cessation Counselling in Primary Care Using a Chronic Disease Management System
Status: UNKNOWN
Conditions: Delivery of Health Care|Smoking Cessation
Interventions: OTHER: New, improved smoking cessation management module
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Fluticasone Nasal Spray Patient Preference Study
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial
Interventions: DRUG: fluticasone propionate (FP)|DRUG: fluticasone furoate (FF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: |Primary Purpose: TREATMENT
Clinical trial: Determination of Parathyroid Function by Fluorescence With Indocyanine Green (ICG) After Total Thyroidectomy
Status: UNKNOWN
Conditions: Hypocalcemia|Total Thyroidectomy|Hypoparathyroidism Postprocedural
Interventions: DRUG: Indocyanine Green
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Mitoxantrone Hydrochloride Liposome Injection in the Treatment of Relapsed Ovarian Cancer
Status: TERMINATED
Conditions: Platinum-resistant Ovarian Cancer
Interventions: DRUG: Mitoxantrone Hydrochloride Liposome, intravenous injection (IV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Bilberry-based Probiotic Product on Glucose Tolerance and Insulin Resistance
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: OTHER: Bilberry|OTHER: beverage without bilberries or probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Microbial Colonization and Change of Chronic Keratinized Hand Eczema After Using Halometasone Triclosan
Status: COMPLETED
Conditions: Chronic Hand Eczema
Interventions: DRUG: Halometasone Triclosan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study to Evaluate the Efficacy and Safety of Cenerimod in Subjects Suffering From Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: Lupus Erythematosus, Systemic
Interventions: DRUG: Cenerimod|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Goal-directed Resuscitation in High-risk Patients Undergoing Cardiac Surgery
Status: COMPLETED
Conditions: Perioperative Hemodynamic Optimization|Cardiac Surgery
Interventions: OTHER: Goal-directed Resuscitation Therapy (GDT)|OTHER: Standard protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sensing and Defibrillation With a Commercially Available ICD Coupled With a Parasternal Extravascular Lead (SECURE EV) Study
Status: COMPLETED
Conditions: Ventricular Arrhythmia|Ventricular Tachycardia|Ventricular Fibrillation
Interventions: DEVICE: AtaCor EV-ICD Lead
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Novel VIRTUAL Reality Intervention for CAREgivers of People With Dementia (VirtualCare)
Status: RECRUITING
Conditions: Caregiver Burden
Interventions: BEHAVIORAL: Psychoeducation|BEHAVIORAL: Psychoeducation + virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: S-1 Plus Oxaliplatin Compared With Fluorouracil, Leucovorin Calcium Plus Oxaliplatin as Perioperative Chemotherapy for Advanced Gastric Carcinoma
Status: COMPLETED
Conditions: Stomach Neoplasms
Interventions: DRUG: S-1; Oxaliplatin; 5-Fu; Leucovorin Calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing TAP Blocks Bupivacaine, and Placebo for Plane
Status: RECRUITING
Conditions: Abdominal Surgery
Interventions: DRUG: Liposomal bupivacaine|DRUG: Plain bupivacaine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of LDE225 (Sonidegib) in Combination With Docetaxel in Triple Negative (TN) Advanced Breast Cancer (ABC) Patients
Status: COMPLETED
Conditions: Advanced Breast Cancer
Interventions: DRUG: LDE225|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib, Fluorouracil, and External-Beam Radiation Therapy in Treating Patients With Stage II, Stage III, or Stage IV Rectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: bortezomib|DRUG: fluorouracil|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension of SoluMatrix TM Abiraterone Acetate in Patients Who Completed Study Number CHL-AA-201
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: SoluMatrix™ Abiraterone Acetate|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inter- and Multidisciplinary, Cross-sectoral Feto-neonatal Pathway
Status: ACTIVE_NOT_RECRUITING
Conditions: Pre-Eclampsia|Intrauterine Growth Restriction|Maternal Care for Known or Suspected Poor Fetal Growth
Interventions: OTHER: consecutive fetoneonatal healthcare pathway
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: DOvEEgene: Diagnosing Ovarian and Endometrial Cancer Early Using Genomics
Status: RECRUITING
Conditions: Ovarian Neoplasms|Endometrial Neoplasms|Endometrial Cancer|Ovarian Cancer|Screening|Safety|Reduced Mortality|Reduced Morbidity|Early Diagnosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells (GXCPC1) for Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: GXCPC1|DEVICE: HA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) as Add-on to Ezetimibe Therapy in Patients With Elevated LDL-C (CLEAR Tranquility)
Status: COMPLETED
Conditions: Hypercholesterolemia|Atherosclerosis|Statin Adverse Reaction
Interventions: DRUG: Bempedoic acid|DRUG: Ezetimibe|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Supplementation Decreases Inflammation and Fetal Obesity in Pregnancy
Status: COMPLETED
Conditions: Inflammation|Obesity|Pregnancy|Fetal Growth
Interventions: DIETARY_SUPPLEMENT: Omega-3 Fish Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intramuscular Ketorolac at Two Single-Dose Regimens
Status: COMPLETED
Conditions: Musculoskeletal Pain|Analgesia|Adverse Event
Interventions: DRUG: Ketorolac Injection 15 mg|DRUG: Ketorolac Injection 60 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Relapse Prevention and the Effectiveness of Long-acting Injectable Risperidone and Quetiapine Tablets in the Treatment of Patients With Schizophrenia or Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders
Interventions: DRUG: Aripiprazole|DRUG: Risperidone Long Acting Injectable (LAI)|DRUG: Quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Concurrent Lenvatinib and Radiotherapy for Advanced HCC
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma|Radiotherapy|Lenvatinib
Interventions: RADIATION: concurrent lenvatinib and Radiotherapy, followed lenvatinib maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study to Assess the Delivery of Dapivirine From a Matrix Vaginal Ring
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: dapivirine|DRUG: placebo|DRUG: dapivirine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trials for the Optimal Dosage of Tang Ning Tongluo Capsule
Status: COMPLETED
Conditions: Accidental Exposure While Preparing Drug for Administration
Interventions: DRUG: TNTL capsule|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Carboplatin/Pralatrexate in Recurrent Platinum-Sensitive Ovarian, Fallopian or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Cancer
Interventions: DRUG: carboplatin|DRUG: pralatrexate|DRUG: Folic Acid|DRUG: Vitamin B12 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pegylated Liposomal Doxorubicin (Doxil) With Rituximab in Relapsed AIDS-Related Non-Hodgkin's Lymphomas
Status: TERMINATED
Conditions: Non-Hodgkin's Lymphoma|Burkitt Lymphoma|Primary Effusion Lymphomas
Interventions: DRUG: Pegylated Liposomal Doxorubicin (Doxil) and Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Obstructive Sleep Apnea Syndrome: Evaluation of the Efficacy of Sleepinnov© (Spiri+) Continuous Positive Airway Pressure Device
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndrome
Interventions: DEVICE: Spiri+
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TBI Dose De-escalation for Fanconi Anemia
Status: COMPLETED
Conditions: Fanconi Anemia
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|PROCEDURE: Total Body Irradiation|PROCEDURE: Bone Marrow Transplantation|DRUG: Mycophenolate Mofetil|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tumour Response to Tirapazamine During Treatment of Cervical Cancer
Status: TERMINATED
Conditions: Cervix Cancer
Interventions: PROCEDURE: Cervical tissue biopsy analysis: Comet assay|PROCEDURE: Biopsy: Measurement of histone gamma H2AX phosphorylation|PROCEDURE: Biopsy: Immunohistochemistry: Ca9, Glut1, HIF-1 alpha|PROCEDURE: Measurement of vascular perfusion: contrast enhanced MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ELND005 in Patients With Mild to Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Placebo Control|DRUG: ELND005|DRUG: ELND005|DRUG: ELND005
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Internal and External Preoperative Biliary Drainage in Periampullary Cancers
Status: COMPLETED
Conditions: Periampullary Cancers With Obstructive Jaundice|Pancreas Head Cancer|Bile Duct Cancer|Ampulla of Vater Cancer
Interventions: PROCEDURE: biliary drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CC-486 and Nivolumab for the Treatment of Hodgkin Lymphoma Refractory to PD-1 Therapy or Relapsed
Status: RECRUITING
Conditions: Recurrent Classic Hodgkin Lymphoma|Refractory Classic Hodgkin Lymphoma
Interventions: BIOLOGICAL: Nivolumab|DRUG: Oral Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT