pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Bortezomib, Melphalan, and Dexamethasone in Treating Patients With Primary Amyloidosis or Light Chain Deposition Disease
Status: COMPLETED
Conditions: Primary Systemic Amyloidosis|Light Chain Deposition Disease
Interventions: DRUG: bortezomib|DRUG: dexamethasone|DRUG: melphalan|GENETIC: microarray analysis|OTHER: flow cytometry|OTHER: laboratory biomarker analysis|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concurrent Pemetrexed/Cisplatin With Pleural Intensity Modulated Radiation Therapy for Patients With Unresectable Malignant Pleural Mesothelioma
Status: WITHDRAWN
Conditions: Malignant Pleural Mesothelioma
Interventions: DRUG: Pemetrexed/Cisplatin|RADIATION: Pleural Intensity Modulated Radiation Therapy|DEVICE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bright Light Therapy Efficacy for Depressive Symptoms Following Cardiac Surgery or Acute Coronary Syndrome: Pilot Trial
Status: COMPLETED
Conditions: Depressive Symptoms Post Cardiac Surgery or Post Acute Coronary Syndrome
Interventions: DEVICE: Bright Light Therapy Lamp|DEVICE: Modified Dim Lamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of REL-1017 as Monotherapy for Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: REL-1017|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Extended Release (ER) Tramadol Hydrochloride (HCl)/Acetaminophen in Participants With Chronic Low-Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: Tramadol HCl/acetaminophen Extended Release|DRUG: Placebo|DRUG: Tramadol HCl/acetaminophen Extended Release|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ph 2B/3 Tafenoquine (TFQ) Study in Prevention of Vivax Relapse
Status: COMPLETED
Conditions: Malaria, Vivax
Interventions: DRUG: Chloroquine 600mg|DRUG: Chloroquine 300mg|DRUG: Tafenoquine 50mg|DRUG: Tafenoquine 100mg|DRUG: Tafenoquine 300mg|DRUG: Tafenoquine 600mg|DRUG: Primaquine 15mg|DRUG: Chloroquine 600mg (Part 2 )|DRUG: Chloroquine 300mg (Part 2 )|DRUG: Tafenoquine 300mg (Part 2)|DRUG: Primaquine 15mg (Part2 )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enoxaparin Bioequivalence Study in Acute Coronary Syndrome Patients
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Lovenox|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Serratus Anterior Plan Block and Postoperative Pain in Patients Who Underwent Minimally Invasive Cardiac Surgery
Status: COMPLETED
Conditions: Morphine Consumption|Pain
Interventions: PROCEDURE: SAPB (Serratus Anterior Plan) Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pilot Study to Evaluate the Safety and Efficacy of Clevudine or Adefovir Patients With LC-B
Status: COMPLETED
Conditions: Patients With LC-B
Interventions: DRUG: Clevudine|DRUG: Adefovir dipivoxil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Biomarkers for Diagnosis and Follow-up of Patients With LRBA or CTLA4 Deficiencies
Status: UNKNOWN
Conditions: LRBA Deficiency|CTLA4 Haploinsufficiency
Interventions: DRUG: Abatacept Injection [Orencia]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Breathing Exercises on Pain, Range of Motion and Neck Disability in Patients With Cervical Spondylosis
Status: COMPLETED
Conditions: Cervical Spondylosis
Interventions: OTHER: Diaphragmatic and pursed lip breathing|OTHER: Routine Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eurythmy Therapy (ERYT) as a Treatment Option for Fatigue in Metastatic Breast Cancer Patients
Status: RECRUITING
Conditions: Fatigue|Breast Cancer
Interventions: OTHER: Eurythmy therapy|OTHER: CoordiFit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Omega-3 Fatty Acids on Insulin Sensitivity in Chinese Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Type 2 Diabetes|Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: Fish Oil Supplementation|DIETARY_SUPPLEMENT: Flaxseed Oil Supplementation|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Comprehensive Approach To Relief Of Digestive Symptoms In Cystic Fibrosis: CARDS-CF
Status: COMPLETED
Conditions: Cystic Fibrosis|Digestive System Disease|Genetic Disease|Respiratory Tract Diseases|Lung Diseases|Pancreatic Disease
Interventions: OTHER: Focus group|OTHER: Patient interview (n = approximately 10)|OTHER: Questionnaire (n = 180)|DEVICE: Testing of the pilot PROM in a smartphone app (n = 150)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Determine the Efficacy of Lenalidomide Versus Investigator's Choice in Patients With Relapsed or Refractory Mantle Cell Lymphoma (MCL)
Status: COMPLETED
Conditions: Mantle Cell Lymphoma|Lymphoma, Mantle-Cell
Interventions: DRUG: Lenalidomide|DRUG: Investigators choice single agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dexmedetomidine on the Duration of Pain Control in ESP Block for Breast Surgery
Status: UNKNOWN
Conditions: Breast Cancer|Mastectomy|Axillary Lymph Node Dissection|Pain, Postoperative
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nab-paclitaxel Combined With Cadonilimab (AK104) for the Second-line Treatment of Advanced Gastric Cancer
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Nab-paclitaxel Combined With Cadonilimab (AK104)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Frailty Index and Geriatric Assessment in Predicting Toxicity to Front-Line Chemotherapy in Treating Patients With Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Recurrent Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: DRUG: cisplatin|DRUG: carboplatin|OTHER: questionnaire administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pembrolizumab in the Treatment of Advanced, Progressive Adrenocortical Carcinoma.
Status: RECRUITING
Conditions: Adrenocortical Carcinoma
Interventions: DRUG: Pembrolizumab 25 MG/ML [Keytruda]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Tolerability of Cinacalcet in Pediatric Patients With Chronic Kidney Disease and Secondary Hyperparathyroidism
Status: TERMINATED
Conditions: Chronic Kidney Disease|Hyperparathyroidism, Secondary
Interventions: DRUG: Cinacalcet hydrochloride|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Colonization of Bile Ducts and Postoperative Infectious Complications of Pancreaticoduodenectomies
Status: COMPLETED
Conditions: Pancreatic Cancer|Sepsis|Bile Duct Cancer|Duodenal Cancer|Bile Duct; Obliteration|Post-Op Complication|Post-Op Infection|Fistula, Biliary|Fistula|Delayed Gastric Emptying
Interventions: OTHER: Bile sampling for bacterial examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effectiveness of Three Anti-HIV Drug Combinations in HIV-Infected Patients Who Have Never Used Anti-HIV Drugs
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Lamivudine|DRUG: Stavudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Sms-guided Training After Acute Stroke or Transient Ischemic Attack - a Randomized Controlled Trial
Status: UNKNOWN
Conditions: Acute Stroke|TIA (Transient Ischemic Attack)
Interventions: OTHER: Outdoor walking and strength exercise|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aortic Valve Replacement With Trifecta(TM)
Status: COMPLETED
Conditions: Aortic Valve Insufficiency|Regurgitation, Aortic Valve|Aortic Valve Incompetence|Aortic Valve Stenosis
Interventions: DEVICE: Trifecta aortic heart valve
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of an Intratumoral Oncolytic Virus in Patients With Advanced Metastatic Solid Tumors
Status: COMPLETED
Conditions: Metastatic Cancer|Solid Tumors|Advanced Cancer
Interventions: BIOLOGICAL: ASP9801|COMBINATION_PRODUCT: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Matrix Metalloproteinases in Patients With Critical Limb Ischemia Undergoing Surgical Revascularization
Status: COMPLETED
Conditions: Critical Limb Ischemia|Extracellular Matrix Alteration|Peripheral Revascularisation
Interventions: PROCEDURE: Polytetrafluoroethylene (PTFE) bypass grafting.|PROCEDURE: Autogenous vein bypass grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Observational Prospective Study to Evaluate AEs, Risk Factors and Drug Utilization of BUSCAPINA COMPOSITUM N in Adults From Metropolitan Lima
Status: COMPLETED
Conditions: Acute Pain|Dysmenorrhea
Interventions: DRUG: Hyoscine n-butylbromide|DRUG: Paracetamol|DRUG: Hyoscine n-butylbromide|DRUG: Paracetamol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Blood Flow Restriction in Post-surgery Rehabilitation of Latarjet Procedure
Status: NOT_YET_RECRUITING
Conditions: Shoulder Dislocation
Interventions: DEVICE: Blood flow restriction (50% AOP compression) in the rehabilitation phase after Latarjet surgery for chronic shoulder instability|DEVICE: Blood flow restriction (10% AOP compression) in the rehabilitation phase after Latarjet surgery for chronic shoulder instability
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Joint Status in Subjects With Severe Hemophilia A in Relation to Different Treatment Regimens
Status: COMPLETED
Conditions: Hemophilia A
Interventions: PROCEDURE: No Drug|PROCEDURE: No Drug|PROCEDURE: No Drug|PROCEDURE: No Drug|PROCEDURE: No Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Povidone Iodine Nasal Application to Prevent Intraoperative Spread of SARS-CoV-2
Status: WITHDRAWN
Conditions: SARS-CoV-2 Acute Respiratory Disease
Interventions: DRUG: Povidone Iodine 5% Soln,Top,Kit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Short-term Effect of Exercise and Self-manual Approaches to Bloating - Distention
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastrointestinal System Disease|Functional Bloating|Distension; Bowel|Gastrointestinal Motility Disorder|Pelvic Floor Dyssynergia
Interventions: OTHER: Group 1 (exercise and self-manual approaches targeting only the diaphragm muscles)|OTHER: Group 2 (exercise and self-manual approaches targeting both diaphragm and core muscles)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Observational Cohort Study Evaluating Fatty Liver Disease and Liver Fibrosis in Moderate to Severe Psoriasis
Status: UNKNOWN
Conditions: Psoriasis Chronic|Liver Fibrosis|Fatty Liver|Non-alcoholic Fatty Liver Disease
Interventions: DEVICE: Transient elastography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: BCI-FES Therapy for Stroke Rehabilitation
Status: RECRUITING
Conditions: Ischemic Stroke|Hemorrhagic Stroke
Interventions: DEVICE: BCI-FES dorsiflexion therapy|BEHAVIORAL: Physiotherapy one hour|BEHAVIORAL: Physiotherapy two hours
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Modalities on Exercise Performance and Post-exercise Recovery of CrossFit® Athletes
Status: COMPLETED
Conditions: Muscle Strength
Interventions: DEVICE: PBMT-sMF|DEVICE: Shock wave|DEVICE: Pneumatic compression|OTHER: Passive recovery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate A Range of Dose Levels of Ad26.ZEBOV and MVA-BN-Filo in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Ad26.ZEBOV 5*10^10 viral particles (vp)|BIOLOGICAL: Ad26.ZEBOV 2*10^10 (vp)|BIOLOGICAL: Ad26.ZEBOV 0.8*10^10 (vp)|BIOLOGICAL: MVA-BN-Filo 1*10^8 Infectious Unit [Inf. U.]|BIOLOGICAL: MVA-BN-Filo 5*10^7 Inf. U.|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Frequency of Cognitive Dysfunction in Patients With Chronic Low Back Pain
Status: COMPLETED
Conditions: Cognitive Dysfunction|Low Back Pain
Interventions: DIAGNOSTIC_TEST: visual pain scale (VASpain/fatigue), Beck depression index (BDI),|DIAGNOSTIC_TEST: Pain catastrophizing scale, sleep quality with a single Likert type question in the Pittsburgh questionnaire|DIAGNOSTIC_TEST: Roland Morris Disability Questionnaire, quality of life with Short Form-36 ( SF-36),|DIAGNOSTIC_TEST: Montreal Cognitive Assessment Scale (MOCA); Standard Mini mental test (SMMT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 2 Study to Evaluate Safety & Efficacy of VPI-2690B in Diabetic Nephropathy Patients
Status: COMPLETED
Conditions: Diabetic Nephropathy
Interventions: DRUG: VPI-2690B low dose|DRUG: VPI-2690B medium dose|DRUG: Placebo to match VPI-2690B|DRUG: VPI-2690B high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy With Our Without Exposure Therapy for Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy without exposure|BEHAVIORAL: Cognitive Behavioral Therapy with exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuroprotective Effect of (Nano PSO), in Patients Who Used to Consume Psychoactive Substances
Status: RECRUITING
Conditions: Addiction;Drug(S);LSD|Neuroprotective
Interventions: DIETARY_SUPPLEMENT: Nano-PSO, Pomegranate seed oil (omega-5)|OTHER: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype
Status: RECRUITING
Conditions: Glioma|Glioblastoma|High Grage Glioma|Low Grade Glioma|Malignant Glioma
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IAEA-HypoX. Accelerated Radiotherapy With or Without Nimorazole in Squamous Cell Carcinoma of the Head and Neck
Status: TERMINATED
Conditions: Head and Neck Carcinoma
Interventions: RADIATION: Accl. RT|RADIATION: Accl. radiotherapy + Nimorazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of PROCRIT (Epoetin Alfa) 80,000 Units (U) Once Every Four Weeks (Q4W) vs. 40,000 U Once Every Two Weeks (Q2W) in Cancer Patients Not Receiving Chemotherapy
Status: TERMINATED
Conditions: Anemia|Cancer|Epoetin Alfa
Interventions: DRUG: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is it Necessary to Set External PEEP in AECOPD Patients
Status: COMPLETED
Conditions: Acute Exacerbation Chronic Obstructive Pulmonary Disease
Interventions: OTHER: PEEP titration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Algorithm Guided Treatment Strategies for Major Depressive Disorder
Status: UNKNOWN
Conditions: Major Depressive Disorder
Interventions: DRUG: Escitalopram|DRUG: Mirtazapine|OTHER: modified electroconvulsive therapy|OTHER: repetitive transcranial magnetic stimulation|DRUG: Fluoxetine|DRUG: Citalopram|DRUG: Escitalopram|DRUG: Paroxetine|DRUG: Sertraline|DRUG: Fluvoxamine|DRUG: Venlafaxine|DRUG: Duloxetine|DRUG: Mirtazapine|DRUG: Bupropion|DRUG: Trazodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adaptive Bridging RT in R/R B-cell Lymphoma (Pre-CAR T)
Status: RECRUITING
Conditions: Lymphoma, B-Cell|Relapsed Cancer|Refractory Lymphoma|Diffuse Large B Cell Lymphoma|Mediastinal Large B-cell Lymphoma|High-grade B-cell Lymphoma|Follicular Lymphoma|Mantle Cell Lymphoma
Interventions: RADIATION: Adaptive Bridging Radiation Therapy (ABRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Clinical, Radiomics and Molecular Features of Lung Metastasis in PDAC Patients (LUMACA Trial)
Status: UNKNOWN
Conditions: Pancreas Adenocarcinoma
Interventions: GENETIC: Analysis of genetic mutations and the gene expression profile of lung metastasis and primary neoplasia|OTHER: Radiomics analysis on TAC imaging at diagnosis of lung metastasis and, if possible, of the primary tumor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Project ARTISAN: Fostering Aspiration and Resilience Through Intergenerational Storytelling and Arts-based Narratives
Status: UNKNOWN
Conditions: Intergenerational Relations|Loneliness|Identity, Social
Interventions: BEHAVIORAL: ARTISAN
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Multiple Dose Investigational Drug Study in Patients With Type 2 Diabetes (MK-0941-005)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: MK0941|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE)
Status: RECRUITING
Conditions: Gynecologic Cancer|Skin Cancer|Head and Neck Cancer|Sarcoma|Renal Cancer|Bladder Cancer|Upper Urinary Tract Carcinoma|Pancreatic Cancer|Hepatobiliary Cancer|Gastric Cancer|Small Bowel Cancer|Esophageal Cancer|Melanoma|Colon Cancer|Oligometastasis
Interventions: RADIATION: Stereotactic body radiotherapy|RADIATION: Palliative RT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension
Status: COMPLETED
Conditions: Adverse Effect
Interventions: DRUG: Norepinephrine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety and Efficacy of COVID-19 Convalescent Plasma (CCP) Transfusion to Prevent COVID-19 in Adult Recipients Following Hematopoietic Stem Cell Transplantation
Status: RECRUITING
Conditions: COVID-19|Hematopoietic Stem Cell Transplantation
Interventions: BIOLOGICAL: COVID Convalescent Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetic Profile in Plasma and Epithelial Lining Fluid of Finafloxacin
Status: COMPLETED
Conditions: Safety and Tolerability
Interventions: DRUG: Finafloxacin 800 mg (as 4 x 200 mg tablet) once daily for 3 days
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Trial to Assess the Functionality of an Integrated Call Center for the Digital Medicine System
Status: COMPLETED
Conditions: Schizophrenia|Major Depressive Disorder|Bipolar I Disorder
Interventions: DRUG: Aripiprazole + IEM (Ingestible Event Marker)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Pembrolizumab for Patients With Locally Advanced Esophageal Squamous Cell Carcinoma at High Risk of Recurrence
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Activity Advices to Prevent Loss of Autonomy in Cancer Treated Elderly Patients. An Intervention Randomized Study
Status: COMPLETED
Conditions: Cancer|Elderly Population
Interventions: OTHER: Adapted physical activity|OTHER: Classic physical activities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: MDX-060 in Patients With Relapsed or Refractory Classic Systemic or Primary Cutaneous Anaplastic Large Cell Lymphoma
Status: WITHDRAWN
Conditions: Lymphoma, Large-Cell
Interventions: DRUG: MDX-060
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Herceptin (Trastuzumab) Combination Therapy in Patients With Metastatic Urothelial Cancer
Status: COMPLETED
Conditions: Urinary Tract Cancer
Interventions: DRUG: trastuzumab|DRUG: gemcitabine|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Community Models for Hypertension and Diabetes Care for Refugees
Status: TERMINATED
Conditions: Hypertension|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2|Comorbidities and Coexisting Conditions
Interventions: OTHER: Improved Community Health Volunteer (CHV) program
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD9977 in Japanese Healthy Participants With Single and Multiple Ascending Dose Administration
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: AZD9977|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Safety & Efficacy of Combination BMS-201038 (AEGR-733) & Ezetimibe vs. Monotherapy in Moderate Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: BMS-201038 (AEGR-733)|DRUG: Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Lifespan Integration for Posttraumatic Stress Disorder From an Auto Accident
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Lifespan Integration Therapy|BEHAVIORAL: Lifespan Integration- Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography in Determining Stage of Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: PROCEDURE: conventional surgery|PROCEDURE: positron emission tomography|PROCEDURE: radionuclide imaging|RADIATION: fludeoxyglucose F 18|DRUG: chemotherapy|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Dry Needling in Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Dry Needling|OTHER: Sham Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Reproducibility of Dual Beam Doppler Fourier-domain Optical Coherence Tomography in Healthy Subjects
Status: UNKNOWN
Conditions: Ocular Blood Flow
Interventions: DEVICE: Dual beam Doppler Fourier-domain OCT (DOCT)|DEVICE: Dynamic Vessel Analyzer (DVA)|DEVICE: Optical coherence tomography (OCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Beta-Glucan and Monoclonal Antibody 3F8 in Treating Patients With Metastatic Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: BIOLOGICAL: beta-glucan|BIOLOGICAL: monoclonal antibody 3F8|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bilateral Prefrontal Modulation in Crack-cocaine Addiction
Status: COMPLETED
Conditions: Drug Addiction|Executive Dysfunction
Interventions: DEVICE: transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Response of Vasomera (PB1046) Injection Following a Single Subcutaneous Dose in Subjects With Stage 1 or 2 Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Vasomera (PB1046)|DRUG: 0.9% Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy With or Without Strontium-89 in Treating Patients With Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Docetaxel|DRUG: Doxorubicin hydrochloride|DRUG: Estramustine phosphate sodium|DRUG: Ketoconazole|DRUG: Prednisone|DRUG: Vinblastine|RADIATION: Strontium chloride Sr 89|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pacemaker Utilization and Ventricular Pacing in Patients Undergoing Trans-catheter Aortic Valve Replacement (TAVR)
Status: COMPLETED
Conditions: Ventricular Flutter|Atrioventricular Block|Intraventricular Conduction Delay|Bundle Branch Block|Pacemaker Implantation
Interventions: DEVICE: Permanent Pacemaker Placement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluate the Safety of Depakote Extended Release Tablets in the Treatment of Mania Associated With Bipolar Disorder in Children and Adolescents
Status: COMPLETED
Conditions: Bipolar I Disorder, Manic or Mixed
Interventions: DRUG: divalproex sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Position Influence the Diagnosis of Detrusor Overactivity in a Neurological Population
Status: RECRUITING
Conditions: Urodynamic Exam|Neurologic Disorder
Interventions: OTHER: urodynamic exam in sitting and lying position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Prasugrel and Ticagrelor in the Treatment of Acute Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction|Angioplasty, Balloon, Coronary|Platelet Aggregation Inhibitors
Interventions: DRUG: Prasugrel|DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study in China - Tolerability of a Single Dose of Abatacept 30 mg/kg
Status: COMPLETED
Conditions: Lupus Nephritis
Interventions: DRUG: Placebo|DRUG: Abatacept|DRUG: Abatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: the Incidence of Necrotizing Enterocolitis in Preterm With Respiratory Distress Syndrome Undergoing Caffeine Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Pharmacological Action of Drug
Interventions: DRUG: Caffeine citrate|DRUG: Amikacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Exploratory Study of Vγ2Vδ2 T Lymphocyte-based Immunotherapy for MDR-TB
Status: RECRUITING
Conditions: MDR-TB|Immunotherapy
Interventions: DRUG: Vγ2Vδ2 T lymphocyte-based immunotherapy|DRUG: Treatment regimens for MDR-TB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxytyrosol and Vitamin E in Pediatric NASH
Status: COMPLETED
Conditions: NAFLD
Interventions: DRUG: Hydroxytyrosol plus Vitamin E|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Event-related Potentials in Management of Children With Attention-deficit/Hyperactivity Disorder
Status: UNKNOWN
Conditions: Attention Deficit Disorders With Hyperactivity|Attention Deficit Disorder|Hyperkinetic Syndrome
Interventions: DRUG: methylphenidate|DRUG: Atomoxetine|BEHAVIORAL: behavioral modification
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess Various Sunitinib Schedules in Renal Cell Carcinoma
Status: UNKNOWN
Conditions: Kidney Neoplasms|Metastatic Renal Cell Cancer
Interventions: DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Followed by PNEUMOVAX™23 in Adults at Increased Risk for Pneumococcal Disease (V114-017/PNEU-DAY)
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: V114|BIOLOGICAL: Prevnar 13™|BIOLOGICAL: PNEUMOVAX™23
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Magnetic Tape on Isometric Hip Strength in Patients With Low Back Pain. RCT
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DEVICE: Magnetic Tape|DEVICE: kinesiology tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between White Light Endoscopy and Bright Narrow Band Imaging in Diagnosis Colonic Adenomas.
Status: WITHDRAWN
Conditions: Colonic Adenomas
Interventions: OTHER: Bright Narrow Band Imaging.|OTHER: White Light Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Avelumab, Utomilumab, Rituximab, Ibrutinib, and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma or Mantle Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Diffuse Large B-Cell Lymphoma|Recurrent Mantle Cell Lymphoma|Refractory Diffuse Large B-Cell Lymphoma|Refractory Mantle Cell Lymphoma|Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma
Interventions: PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation|DRUG: Avelumab|DRUG: Carboplatin|DRUG: Etoposide Phosphate|DRUG: Ibrutinib|DRUG: Ifosfamide|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Rituximab|BIOLOGICAL: Utomilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LVN- IUS Versus Oral Megesterol Acetate in Treatment of Atypical Endometrial Hyperplasia
Status: COMPLETED
Conditions: Atypical Endometrial Hyperplasia
Interventions: DEVICE: levonorgestrel intrauterine system (LNG-IUD)|DRUG: Oral Megesterol 160 mg daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Treatments in Intermediate and High-risk Acute Promyelocytic Leukemia (APL) Patients to Assess Efficacy in 1st Hematological Complete Remission and Molecular Remission
Status: COMPLETED
Conditions: Leukemia, Myelocytic, Acute
Interventions: DRUG: gemtuzumab ozogamicin|DRUG: ATRA plus 6-MP and MTX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TASK-002: Bioequivalence of Bedaquiline 400mg Administered in Crushed Form Compared to Tablet Form in Healthy Male and Female Adults Under Fed Conditions (BDQ Crush Study)
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: bedaquiline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies
Status: UNKNOWN
Conditions: Twin Pregnancy|Preeclampsia|Preterm Birth|Fetal Growth Restriction
Interventions: DRUG: Aspirin 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tau Imaging of Chronic Traumatic Encephalopathy
Status: COMPLETED
Conditions: Chronic Traumatic Encephalopathy
Interventions: RADIATION: [F18]-T807|RADIATION: [F18]-Florbetapir|DEVICE: MRI/MRS|GENETIC: Genetic Analysis for Genetic Risk Score for Tau.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of OMS906 in Paroxysmal Nocturnal Hemoglobinuria Patients With a Sub-optimal Response to Ravulizumab
Status: RECRUITING
Conditions: Paroxysmal Nocturnal Hemoglobinuria
Interventions: DRUG: OMS906 Study Drug - 3 mg/kg|DRUG: OMS906 Study Drug - 5 mg/kg|DRUG: Ravulizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tabelecleucel in Combination With Pembrolizumab in Subjects With Epstein-Barr Virus-associated Nasopharyngeal Carcinoma (EBV+ NPC)
Status: TERMINATED
Conditions: Nasopharyngeal Carcinoma|Nasopharyngeal Neoplasms|Epstein-Barr Virus Infections|Epstein-Barr Viraemia|Epstein-Barr Virus-associated Nasopharyngeal Carcinoma (EBV+ NPC)
Interventions: BIOLOGICAL: tabelecleucel|BIOLOGICAL: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nitropaste in Breast Reduction
Status: WITHDRAWN
Conditions: Gynecomastia|Delayed Wound Healing
Interventions: DRUG: Nitroglycerin Paste|DRUG: Dermabond
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Cryoablation, Atezolizumab/Nab-paclitaxel for Locally Advanced or Metastatic Triple Negative Breast Cancer
Status: WITHDRAWN
Conditions: Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Locally Advanced Breast Carcinoma|Metastatic Triple-Negative Breast Carcinoma|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8|Prognostic Stage IV Breast Cancer AJCC v8
Interventions: DRUG: Atezolizumab|PROCEDURE: Cryosurgery|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety of DWP14012 Tablet A and Tablet B in Healthy Volunteers (II)
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: DWP14012 tablet A|DRUG: DWP14012 tablet B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment With Bempedoic Acid and/or Its Fixed-dose Combination With Ezetimibe in Primary Hypercholesterolemia or Mixed Dyslipidemia
Status: RECRUITING
Conditions: Hypercholesterolemia|Mixed Dyslipidemia
Interventions: DRUG: Bempedoic acid and/or its fixed-dose combination with ezetimibe
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Topical PDT Cream Without Irradiation Source in the Acne Treatment
Status: COMPLETED
Conditions: Acne, Photodynamic Therapy
Interventions: DRUG: Topical application of 1.5% Butenyl ALA|DRUG: Topical application of sham control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease
Status: RECRUITING
Conditions: EGFR Activating Mutation|Leptomeningeal Metastasis|Non Small Cell Lung Cancer
Interventions: DIAGNOSTIC_TEST: Lumbar puncture and Phlebotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treatment of Radiation Retinopathy With Open-Label Anecortave Acetate Sterile Suspension (15 mg)
Status: TERMINATED
Conditions: Eye Injuries
Interventions: DRUG: Anecortave Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of SSRIs on Response to Psilocybin Therapy
Status: WITHDRAWN
Conditions: Depression|Major Depressive Disorder|Mild Depression|Moderate Depression|Depressive Disorder
Interventions: DRUG: Psilocybin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maximizing CRT Delivery by Using MultipolAr Coronary Sinus Lead FamiLy ACUITY® X4 - RALLY X4 Study
Status: COMPLETED
Conditions: Heartfailure
Interventions: DEVICE: Left Ventricular lead implant: ACUITY X4® Lead Family
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Camrelizumab as a Maintenance Therapy After Chemoradiation in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: HNSCC
Interventions: DRUG: Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ferrous Fumarate and Ferric Pyrophosphate as Food Fortificants in Developing Countries
Status: COMPLETED
Conditions: Healthy Participants|Non-anemic Children|Helicobacter Pylori Infection
Interventions: DRUG: Ferrous fumarate|DRUG: Ferric pyrophosphate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Copanlisib in Combination With Degarelix in People With Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Copanlisib|DRUG: Degarelix|PROCEDURE: Radical Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irbesartan for the Prevention of Atrial Arrhythmias and Cardiac Electrical Remodeling in Patients With Hypertension and Permanent Pacemakers
Status: UNKNOWN
Conditions: Atrial Fibrillation|Hypertension
Interventions: DRUG: Irbesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Intrarectal Versus Intravenous Quinine for the Treatment of Childhood Cerebral Malaria
Status: UNKNOWN
Conditions: Cerebral Malaria
Interventions: DRUG: Intrarectal quinine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Game Plan for PrEP
Status: COMPLETED
Conditions: Human Immunodeficiency Virus Exposure|Alcohol; Harmful Use
Interventions: BEHAVIORAL: Game Plan for PrEP|BEHAVIORAL: Attention-Matched Control Lifestyle Habits Videos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Real-World Study of Bispecific Antibodies in Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: OTHER: Treated by bispecific antibodies, teclistamab or elranatamab in usual care|OTHER: Not treated by bispecific antibodies in usual care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multimodal Treatment for Hemiplegic Shoulder Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Stroke|Shoulder Pain
Interventions: DEVICE: Peripheral Nerve Stimulation|OTHER: Physical Therapy|OTHER: Sham-PT|DEVICE: Sham-PNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Retinal Microvascular Change That May Develop in Patients After Open Globe İnjury With Optical Coherence Tomography (OCTA)
Status: COMPLETED
Conditions: Eye Injuries
Interventions: OTHER: Optical Coherence Tomography Angiography (OCTA) • Biometry • Auto refractometry • Non contact tonometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Standardized MONitoring for Detection of Atrial Fibrillation in Ischemic Stroke
Status: COMPLETED
Conditions: Stroke|Atrial Fibrillation
Interventions: OTHER: prolonged ECG monitoring|DEVICE: ECG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Paraspinal Block in Nonspecific Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: DRUG: Lidocaine|DRUG: Sham Lidocaine|OTHER: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Ablation Versus Balloon Cryoablation in Elderly Patients With Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: radiofrequency ablation|PROCEDURE: ballon cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to the Usual Radiation Treatment for Newly Diagnosed Early Stage High Intermediate Risk Endometrial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Endometrioid Adenocarcinoma|Stage I Uterine Corpus Cancer AJCC v8|Stage II Uterine Corpus Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|RADIATION: Brachytherapy|PROCEDURE: Computed Tomography|RADIATION: External Beam Radiation Therapy|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Pembrolizumab|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short-Term Linvoseltamab Treatment, on Top of Chronic Dupilumab Treatment, for Adults With Severe Immunoglobulin E (IgE)-Mediated Food Allergy
Status: RECRUITING
Conditions: Food Allergy
Interventions: DRUG: linvoseltamab|DRUG: dupilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravitreal tPA and C3F8 for the Treatment of Submacular Haemorrhage as a Complication of Neovascular AMD
Status: COMPLETED
Conditions: Exudative Macular Degeneration|Retinal Hemorrhage
Interventions: DRUG: Ranibizumab|DRUG: C3F8 Gas|DRUG: tPA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT