pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: CT-P13 (Infliximab) Subcutaneous Administration in Patients With Moderately to Severely Active Ulcerative Colitis (LIBERTY-UC)
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: BIOLOGICAL: CT-P13 SC (Infliximab)|OTHER: Placebo SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of The Quadratus Lumborum Block and Ilioinguinal Iliohypogastric Nerve Block
Status: COMPLETED
Conditions: Post Operative Pain|Inguinal Hernia|Quadratus Lumborum Nerve Block
Interventions: PROCEDURE: ultrasound-guided quadratus lumborum nerve block|PROCEDURE: ultrasound-guided Ilioinguinal Iliohypogastric Nerve Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SH Dr. Chen Gastric Bypass Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Bypass
Interventions: PROCEDURE: Gastric bypass with transection of vagal nerves|PROCEDURE: Gastric bypass without transection of vagal nerves
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intramural Needle Ablation for Ablation of Recurrent Ventricular Tachycardia
Status: COMPLETED
Conditions: Ventricular Tachycardia
Interventions: DEVICE: Intramural Needle Ablation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety, Tolerability, and Immunogenicity of a 9-valent Human Papillomavirus Vaccine ([9vHPV]; V503) Administered to 9- to 15-Year-Old Japanese Girls (V503-008).
Status: COMPLETED
Conditions: Papillomavirus Infections
Interventions: BIOLOGICAL: V503
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of SYHA1807 in Subjects With Extensive-Stage Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Extensive-Stage Small Cell Lung Cancer
Interventions: DRUG: SYHA1807|DRUG: SYHA1807
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Response & Safety of GSK Biologicals' Mencevax™ ACWY in Subjects Primed in the DTPW-HBV=HIB-MENAC-TT-011 Study
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: Tritanrix™- HepB|BIOLOGICAL: Hiberix™|BIOLOGICAL: Mencevax™ ACWY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 1/2/3 Study to Evaluate the Safety, Tolerability, and Immunogenicity of an RNA Vaccine Candidate Against COVID-19 in Healthy Children
Status: COMPLETED
Conditions: SARS-CoV-2 Infection, COVID-19
Interventions: BIOLOGICAL: Biological/Vaccine: BNT162b2 10mcg|BIOLOGICAL: BNT162b2 20mcg|BIOLOGICAL: BNT162b2 30mcg|OTHER: Placebo|BIOLOGICAL: Biological/Vaccine: BNT162b2 3mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Stress and Mental Ill-health in the Workplace: Evaluation of an Intervention for the Prevention of Sick Leave
Status: COMPLETED
Conditions: Common Mental Disorders and/or Stress Related Symptoms
Interventions: BEHAVIORAL: Problem-solving based intervention|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carfilzomib + High Dose Melphalan as Preparative Regimen for Autologous Hematopoietic Stem Cell Transplantation
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Carfilzomib|DRUG: Melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest of a Post-operative Ultrasound With Systematic Use of Ultrasonic Contrast in the Follow-up of Aortic Endoprosthesis: Prospective Study at the University Hospital of Nice
Status: COMPLETED
Conditions: Aneurysm, Abdominal Aortic
Interventions: OTHER: écho-doppler with ultrasonar Sonovue® injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Virtual Reality on Pre-Operative Anxiety and Induction of Anesthesia in Children and Adolescents
Status: UNKNOWN
Conditions: Tonsillectomy
Interventions: DEVICE: Virtual Reality|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of DTPa-IPV/Hib & DTPa-HBV-IPV/Hib, Followed by DTPa-IPV/Hib Vaccine in Infants Who Received Hepatitis B Vaccine
Status: COMPLETED
Conditions: Haemophilus Influenzae Type b|Diphtheria|Tetanus|Poliomyelitis|Acellular Pertussis
Interventions: BIOLOGICAL: DTPa-HBV-IPV/Hib|BIOLOGICAL: DTPa-IPV/Hib vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Rapid Local Ischemic Postconditioning in Acute Ischemic Stroke
Status: NOT_YET_RECRUITING
Conditions: Acute Ischemic Stroke|Mechanical Thrombectomy|Ischemic Postconditioning|Brain Edema
Interventions: PROCEDURE: rapid local ischemic postconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Mindfulness Meditation for Adults 65+ With Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: BEHAVIORAL: Mindfulness based stress reduction program|OTHER: Wait-list control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Everolimus, Letrozole and Trastuzumab in HR- and HER2/Neu-positive Patients
Status: COMPLETED
Conditions: Advanced Malignant Solid Neoplasm|Estrogen Receptor Positive|HER2/Neu Positive|Postmenopausal|Premenopausal|Progesterone Receptor Positive|Recurrent Breast Carcinoma|Refractory Breast Carcinoma|Refractory Hormone Receptor Positive Breast Carcinoma|Stage IIIA Breast Cancer AJCC v7|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7|Stage IV Breast Cancer AJCC v6 and v7
Interventions: DRUG: Everolimus|OTHER: Laboratory Biomarker Analysis|DRUG: Letrozole|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy of Uproleselan in Combination With Chemotherapy in Chinese Patients With R/R AML
Status: UNKNOWN
Conditions: Relapsed/Refractory AML
Interventions: DRUG: Uproleselan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VasQ External Support for Arteriovenous Fistula
Status: COMPLETED
Conditions: Arterio-Venous Fistula|ESRD|Steal Syndrome|Aneurysm|Renal Failure|Renal Disease|Diabetes Mellitus|Kidney Failure
Interventions: DEVICE: VasQ
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clofarabine Plus Cytarabine in Patients With Previously Untreated Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Leukemia, Myeloid|Myelodysplastic Syndromes
Interventions: DRUG: clofarabine|DRUG: Ara-C
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sulfamethoxazole for the Treatment of Primary PREPL Deficiency
Status: UNKNOWN
Conditions: Hypotonia Cystinuria Syndrome|Isolated PREPL Deficiency
Interventions: DRUG: Sulfamethoxazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Registering Genomics and Imaging of Tumors (ReGIT)
Status: RECRUITING
Conditions: Glioma
Interventions: DRUG: FET F-18|DRUG: O-15 Radioisotope|PROCEDURE: CT scan|PROCEDURE: MRI with gadolinium-based contrast|PROCEDURE: Biopsy Collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Application of Whole-body Vibration With Stochastic Resonance in Frail Elderly: The Effects on Postural Control
Status: COMPLETED
Conditions: Equilibration Disorder, Vestibular Nerve
Interventions: DEVICE: Stochastic resonance whole-body vibration A|DEVICE: Stochastic resonance whole-body vibration B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Roselle-based Drink on Blood Pressure and Skin
Status: COMPLETED
Conditions: Other Skin and Subcutaneous Infections
Interventions: DIETARY_SUPPLEMENT: Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRX) Administered to Adults With Familial Chylomicronemia Syndrome (FCS) Previously Treated With Volanesorsen
Status: ACTIVE_NOT_RECRUITING
Conditions: Familial Chylomicronemia Syndrome
Interventions: DRUG: Olezarsen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study, Comparing Two Formulations of Ivermectin Lotion, 0.5%
Status: COMPLETED
Conditions: Lice; Head Lice
Interventions: DRUG: Ivermectin Lotion, 0.5%|DRUG: SKLICE (ivermectin) Lotion, 0.5%|DRUG: Vehicle of the Test product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Deep Brain Stimulation for Voice Tremor: Left, Right, or Both Hemispheres?
Status: COMPLETED
Conditions: Essential Voice Tremor|Deep Brain Stimulation|Essential Tremor|Laryngeal Diseases|Action Tremor|Tremor, Nerve
Interventions: DEVICE: Deep Brain Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Controlled Fluid Administration
Status: UNKNOWN
Conditions: Dehydration (Physiology)|Thirst; Due to Deprivation of Water|Plasma Osmolality Increased|Hypovolemia
Interventions: PROCEDURE: IV Fluid Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Safety and Tolerability of the Derma Vax(Trademark) Clinical Intradermal Electroporation System in Healthy Subjects
Status: COMPLETED
Conditions: Intradermal Electroporation
Interventions: DRUG: EMLA Cream|DRUG: Aveeno Daily Moist|DEVICE: Derma Vax|PROCEDURE: Intradermal Electroporation|PROCEDURE: Visual Analogue Scale|PROCEDURE: Present Pain Intensity|PROCEDURE: McGill Pain Questionnaire|PROCEDURE: Skin Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of a New Blood-based Test to Detect Colorectal Cancer and Its Precursors
Status: COMPLETED
Conditions: Colorectal Cancer|Colorectal Neoplasms|Colorectal Carcinoma|Colorectal Polyp|Colorectal Adenoma
Interventions: DIAGNOSTIC_TEST: CELTiC test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Efficacy & Safety of the Oral Neurokinin-1 Antagonist, Aprepitant, in Combo With Ondansetron & Dexamethasone in Patients Undergoing Auto Peripheral Blood Stem Cell Transplantation
Status: COMPLETED
Conditions: Nausea|Vomiting
Interventions: DRUG: Ondansetron|DRUG: Dexamethasone|DRUG: Aprepitant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn)
Status: COMPLETED
Conditions: Cervical Disc Degenerative Disorder
Interventions: BIOLOGICAL: Cellentra VCBM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Substantially Improving the Cure Rate of High-risk BRCA1-like Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: ddAC-CP-Olaparib|DRUG: ddAC-mini CTC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NAVASET: Nava Level Titration Using Comfort Scales
Status: UNKNOWN
Conditions: Acute Respiratory Failure
Interventions: DEVICE: PSV - pressure support ventilation|DEVICE: Neurally Adjusted Ventilatory Assist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Aceto-whitening in the Assessment of Gastrointestinal Neoplasia
Status: UNKNOWN
Conditions: Barrett Esophagus|Barrett Metaplasia|Barrett Oesophagitis With Dysplasia|Barrett Adenocarcinoma
Interventions: PROCEDURE: Acetic acid chromoendoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: First Line Prevent Age Study
Status: RECRUITING
Conditions: Healthy Aging|Healthy Lifestyle|Healthy Diet
Interventions: OTHER: 1. Nutrition; 2. Physical activity; 3. Hypoxic training; 4. Menthal heals improvement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: SCRATCH-HTN Study: Evaluating Autonomic Neuromodulation Using Trans-cutaneous Vagal Stimulation in Hypertensive Patients
Status: RECRUITING
Conditions: Uncontrolled Hypertension|High Blood Pressure
Interventions: DEVICE: Active AffeX-CT device|DEVICE: Sham AffeX-CT device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Triple Combination Therapy in Patients With Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: bimatoprost/brimonidine tartrate/timolol fixed combination ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Appropriate Timing of Surgery After Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer
Status: COMPLETED
Conditions: Neoplasm, Rectum
Interventions: PROCEDURE: Total mesorectal excision before 56 days (4-8 weeks)|PROCEDURE: Total mesorectal excision after 56 days (8-12 weeks)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 6-mo. Min Eff Dose of Flibanserin: 25 v 50 mg Bid v 50 mg hs v Pbo in Younger Women in NA
Status: COMPLETED
Conditions: Sexual Dysfunctions, Psychological
Interventions: DRUG: flibanserin|DRUG: flibanserin|DRUG: flibanserin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravenous Lidocaine on Serum miRNA-135a in Patients Undergoing Non-cardiac Surgery
Status: UNKNOWN
Conditions: Organ Protection
Interventions: DRUG: Lidocaine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: MRI Study With Ferumoxytol in Assessing Early Response in Patients With Glioblastoma Multiforme Receiving Temozolomide and Radiation Therapy
Status: COMPLETED
Conditions: Adult Brain Glioblastoma
Interventions: DRUG: Gadolinium|DRUG: Ferumoxytol Non-Stoichiometric Magnetite|OTHER: Dynamic Contrast-Enhanced Magnetic Resonance Imaging|OTHER: Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging|OTHER: Diffusion Weighted Imaging|OTHER: MRI-Based Angiogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: THE EFFECT OF AEROBIC AND GAME BASED EXERCISES ON COGNITIVE FUNCTIONS IN DEMENTIA
Status: ACTIVE_NOT_RECRUITING
Conditions: Dementia
Interventions: BEHAVIORAL: Computer Based Exercises|DIETARY_SUPPLEMENT: Aerobic Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of OK-432 Pleurodesis on Postoperative Air Leak
Status: UNKNOWN
Conditions: Postoperative Air Leak
Interventions: DRUG: OK-432 pleurodesis|DRUG: normal saline pleurodesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: [11C]Yohimbine PET Study of alpha2-AR
Status: COMPLETED
Conditions: Healthy Controls
Interventions: DRUG: [11C]Yohimbine|DRUG: [11C]Yohimbine (Part B1) and [11C]Yohimbine + clonidine (Part B2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Periodic Limb Movement Syndrome in Patients With Cerebral Small Vessel Disease.
Status: UNKNOWN
Conditions: Periodic Limb Movement Disorder|Cerebral Small Vessel Diseases|Cognitive Dysfunction
Interventions: DIAGNOSTIC_TEST: Actigraphy|DIAGNOSTIC_TEST: Cardiorespiratory monitoring|DIAGNOSTIC_TEST: Neuroimaging|OTHER: Assessment of cognitive function|OTHER: Sleep quality and mood questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Evaluate the Pharmacokinetics of XNW4107 in Healthy Adult Young Females and in Healthy Adult Elderly Males and Females.
Status: COMPLETED
Conditions: Bacterial Infections
Interventions: DRUG: XNW4107|DRUG: Imipenem/Cilastatin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: MISC-CBO in Children Affected by HIV/AIDS
Status: COMPLETED
Conditions: HIV Affected Children (Single and/or Double Orphans)
Interventions: BEHAVIORAL: Mediational Intervention for Sensitizing Caregivers (MISC)|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: HelpILO - RCT on EILO Treatment
Status: RECRUITING
Conditions: Exercise Induced Laryngeal Obstruction (EILO)
Interventions: PROCEDURE: A: Breathing advice with bio-feedback|PROCEDURE: B: Breathing advice with bio-feedback, Inspiratory muscle training (IMT)|PROCEDURE: C: Breathing advice with bio-feedback, Speech Therapy|PROCEDURE: D: Breathing advice with bio-feedback, IMT and Speech Therapy|PROCEDURE: A: If CLE-test unchanged, additional IMT and Speech Therapy|PROCEDURE: Surgery 1: Supraglottoplasty - full procedure under general anesthesia|PROCEDURE: Surgery 2: Supraglottoplasty - mini-invasive procedure under general anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Innovative Tools to Produce Legume-based Foods for Increased Consumer Acceptance
Status: UNKNOWN
Conditions: IBS - Irritable Bowel Syndrome
Interventions: OTHER: Control cracker|OTHER: Enzyme-treated cracker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Decolonization of Gram-negative Multi-resistant Organisms (MDRO) With Donor Microbiota (FMT)
Status: RECRUITING
Conditions: Resistance Bacterial
Interventions: BIOLOGICAL: Allogenic FMT|BIOLOGICAL: Autologous FMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Ranging Study of an Ocular Sirolimus (Rapamycin) Formulation in Patients With Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Sirolimus|DRUG: Placebo|DRUG: Sirolimus|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Parkinson's Early Stage With Deferiprone
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Deferiprone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Myo-inositol and D-chiro Inositol on the Ovaric and Metabolic Functions
Status: COMPLETED
Conditions: PCOS
Interventions: DIETARY_SUPPLEMENT: Myo-inositol + D-chiro-inositol + Folic acid|DIETARY_SUPPLEMENT: Folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Phase 2a, 28-day Investigational Use Study of ARINA-1 in Non-CF Bronchiectasis With Excess Mucus and Cough
Status: COMPLETED
Conditions: Non-cystic Fibrosis Bronchiectasis
Interventions: DRUG: ARINA-1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Immunotherapy to ESCC
Status: WITHDRAWN
Conditions: Esophagus SCC
Interventions: DRUG: Sintilimab Injection plus Paclitaxel and Cisplatin|DRUG: Paclitaxel and Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Whole Body Vibration and Pilates on Bone Mineral Density in Postmenopausal Women
Status: COMPLETED
Conditions: Bone Mineral Density Quantitative Trait Locus 3
Interventions: OTHER: Whole-Body Vibration|OTHER: Pilates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Two Associations of Rituximab and Chemotherapy, With a PET-driven Strategy, in Lymphoma
Status: COMPLETED
Conditions: Lymphoma, B-Cell|Lymphoma, Large-Cell, Diffuse
Interventions: DRUG: R-CHOP14 induction regimen|DRUG: R-ACVBP14 induction regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-Cost and Reusable Thermal Jacket for Managing Preterm or Low Birth Weight Neonates.
Status: COMPLETED
Conditions: Preterm|Low Birthweight|Hypothermia Neonatal
Interventions: DEVICE: Thermal Jacket
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studying Biological Markers of Fatigue in Women With Residual Invasive Breast Cancer Enrolled on Clinical Trial NSABP-B-45
Status: WITHDRAWN
Conditions: Breast Cancer|Fatigue
Interventions: GENETIC: gene expression analysis|GENETIC: microarray analysis|GENETIC: polymerase chain reaction|GENETIC: polymorphism analysis|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: biologic sample preservation procedure|OTHER: enzyme-linked immunosorbent assay|OTHER: laboratory biomarker analysis|PROCEDURE: fatigue assessment and management
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Reducing REVISITS Study: A Cluster RCT
Status: RECRUITING
Conditions: COPD|COPD Exacerbation Acute
Interventions: BEHAVIORAL: COPD Transitions of Care Intervention Bundle: Virtual Interventions|BEHAVIORAL: COPD Transitions of Care Intervention Bundle: In-Person Interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Neurophysiologic Effects of Cervical Spinal Manipulation in Asymptomatic Individuals
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: OTHER: Cervical spine manual manipulation|OTHER: Cervical spine mechanical manipulation|OTHER: Placebo intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Satisfaction With Placement of Implantable Venous Access Devices in Patients With Solid Tumors
Status: TERMINATED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: OTHER: computer-assisted intervention|OTHER: medical chart review|OTHER: questionnaire administration|OTHER: survey administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Active vs. Passive Voiding Trials on Time to Discharge, Urinary Tract Infection, and Urinary Retention
Status: COMPLETED
Conditions: Urinary Retention|Urinary Tract Infections
Interventions: PROCEDURE: Active Voiding Trial|PROCEDURE: Passive Voiding Trial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-finding, Safety and Efficacy Study of Radium-223 Dichloride (XOFIGO) in RCC Patients With Bone Metastases. (EIFFEL)
Status: UNKNOWN
Conditions: Clear-cell Metastatic Renal Cell Carcinoma|Bone Metastases
Interventions: DRUG: XOFIGO
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Efficacy and Safety of CKD-825 in Patients With Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DRUG: CKD-825|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Crystallized Phenol Treatment in Pilonidal Sinus
Status: COMPLETED
Conditions: Pilonidal Sinus of Natal Cleft|Pilonidal Sinus Without Abscess
Interventions: DRUG: Crystallized phenol application
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Case Manager to Assist the Rehabilitation for Lumbar Spinal Fusion Patients. A Randomised Controlled Trial.
Status: COMPLETED
Conditions: Rehabilitation|Spinal Fusion|Case Managers
Interventions: BEHAVIORAL: Case manager assisted rehabilitation|BEHAVIORAL: Usual physical rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Durvalumab and Tremelimumab in Combination With Propranolol and Chemotherapy for Treatment of Advanced Hepatopancreabiliary Tumors (BLOCKED)
Status: RECRUITING
Conditions: Pancreatic Cancer|Hepatocellular Cancer|Biliary Tract Cancer|Cholangiocarcinoma
Interventions: BIOLOGICAL: Durvalumab|DRUG: Gemcitabine|DRUG: Nab paclitaxel|BIOLOGICAL: Tremelimumab|DRUG: Propranolol|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Testing and Imaging in Improving Response in Patients With Stage I-III Triple-Negative Breast Cancer Receiving Chemotherapy MDACC Breast Moonshot Initiative
Status: RECRUITING
Conditions: Invasive Breast Carcinoma|Stage I Breast Cancer AJCC v7|Stage IA Breast Cancer AJCC v7|Stage IB Breast Cancer AJCC v7|Stage II Breast Cancer AJCC v6 and v7|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7|Stage III Breast Cancer AJCC v7|Stage IIIA Breast Cancer AJCC v7|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7|Triple-Negative Breast Carcinoma
Interventions: DRUG: Chemotherapy|OTHER: Immunotherapy|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Lymph Node Biopsy|PROCEDURE: Ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Neuromuscular Training-Based Exercise Program
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain, Shoulder|Sports Physical Therapy
Interventions: OTHER: Neuromuscular Training-based Exercise Program|OTHER: ''Thrower's Ten'' Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of PD-1 Monoclonal Antibody SHR-1210 and Apatinib in Advanced NSCLC, Soft Tissue Sarcoma, and Uterine Cancer
Status: UNKNOWN
Conditions: Advanced Non Small Cell Lung Cancer|Uterine Cancer|Soft Tissue Sarcoma
Interventions: DRUG: PD-1 inhibitor|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Driving Pressure During General Anesthesia for Open Abdominal Surgery
Status: RECRUITING
Conditions: Postoperative Respiratory Complication
Interventions: PROCEDURE: Individualized high PEEP strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First-line Carboplatin and Paclitaxel in Combination With Pembrolizumab, Followed by Maintenance Pembrolizumab With or Without Nesuparib, in Patients With Newly Diagnosed Advanced or Recurrent MMR-proficient (pMMR) Endometrial Cancer
Status: NOT_YET_RECRUITING
Conditions: Endometrial Cancer|Recurrent Endometrial Carcinoma|Endometrial Carcinoma|Gynecologycal Cancer|Endometrial Neoplasms
Interventions: DRUG: Nesuparib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of NNC0109-0012, an Anti-IL-20 Biologic, in Patients With Active Rheumatoid Arthritis Who Are Inadequate Responders to Methotrexate
Status: TERMINATED
Conditions: Inflammation|Rheumatoid Arthritis
Interventions: DRUG: NNC0109-0012|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interscalene Block Versus Costoclavicular Block for Shoulder Surgery
Status: COMPLETED
Conditions: Pain, Postoperative|Shoulder Pain|Surgical Procedure, Unspecified|Diaphragmatic Paralysis
Interventions: PROCEDURE: Interscalene Block|PROCEDURE: Costoclavicular Infraclavicular Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dynamic of Immunocompetent Populations in Patients Treated With Extracorporeal Photopheresis in Chronic Graft Versus Host Disease
Status: RECRUITING
Conditions: Graft Versus Host Disease|Extracorporeal Photopheresis
Interventions: DIAGNOSTIC_TEST: Blood samples|DIAGNOSTIC_TEST: skin biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Laparoscopy in Children: Does it Decrease the Metabolic, Endocrine and Inflammatory Stress Response to Surgery
Status: COMPLETED
Conditions: Gastro-Oesophageal Reflux
Interventions: PROCEDURE: Laparoscopic fundoplication|PROCEDURE: open Nissen fundoplication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Primed vs Unprimed Facilitatory and Depressive Paired Associative Stimulation
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Transcranial Magnetic Stimulation (Magstim)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Imaging of in Vivo Sigma-2 Receptor Expression With 18F-ISO-1 Positron Emission Tomography in Metastatic Breast Cancer
Status: TERMINATED
Conditions: METASTATIC BREAST CANCER
Interventions: DEVICE: Positron emission tomography (PET/CT) imaging|DEVICE: radiotracer [18F]ISO-1
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Concentrations of Amiodarone in Fat Tissue During Chronic Treatment
Status: COMPLETED
Conditions: Arrhythmia|Atrial Fibrillation|Atrial Flutter
Interventions: PROCEDURE: Fat tissue needle aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pilot Study of Genetically Engineered NY-ESO-1 Specific NY-ESO-1ᶜ²⁵⁹T in HLA-A2+ Patients With Synovial Sarcoma
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: NY-ESO-1(c259)T Cells|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Middle Meningeal Artery Embolization With Liquid Embolic Agent for Treatment of Chronic Subdural Hematoma
Status: RECRUITING
Conditions: Chronic Subdural Hematoma
Interventions: PROCEDURE: Embolization of MMA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Treatment of Peri-implantitis Using a Bone Substitute With or Without a Resorbable Collagen Membrane
Status: ENROLLING_BY_INVITATION
Conditions: Peri-Implantitis|Surgery
Interventions: PROCEDURE: InterOss Collagen (Bone xenograft) and InterOss Collagen Guide (Collagen membrane)|PROCEDURE: InterOss Collagen (Bone xenograft)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assuring and Defining Outcomes Through Procedural Training Using a Proctorship Model That Collects Patient Outcomes A Single-Arm, Case-Series to Determine the Feasibility of Safe Skills Transfer for Laparoscopic Ventral Hernia Repair Utilizing a Hands-On Proctorship Model.
Status: COMPLETED
Conditions: Hernia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Curcumin in Children With Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia, Pediatric
Interventions: DRUG: Curcumin|DIETARY_SUPPLEMENT: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Referral Card on Neonatal Medical Care Seeking for Institutional Births in Urban Lucknow
Status: COMPLETED
Conditions: Neonatal Morbidity|Neonatal Illnesses
Interventions: BEHAVIORAL: Referral Card with one-to-one counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Investigate The Effectiveness Of Atezolizumab In Patients With Inoperable Locally-Advanced Or Metastatic Urothelial Carcinoma Of The Urinary Tract (Announce)
Status: TERMINATED
Conditions: Urothelial Carcinoma
Interventions: DRUG: Atezolizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Anti-phobic and Safety Behaviors in the Treatment of Acrophobia
Status: UNKNOWN
Conditions: Specific Phobia
Interventions: BEHAVIORAL: EXP|BEHAVIORAL: EXP + SBF|BEHAVIORAL: EXP + SBF + AA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Empagliflozin and Dapagliflozin in Patients Hospitalized for Acute Decompensated Heart Failure
Status: RECRUITING
Conditions: Acute Decompensated Heart Failure
Interventions: DRUG: Empagliflozin 10 MG|DRUG: Dapagliflozin 10 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Whether Tart Cherry Juice Can Reduce Oxidative Stress and Inflammation
Status: COMPLETED
Conditions: Oxidative Stress|Antioxidant Capacity|Inflammation
Interventions: DIETARY_SUPPLEMENT: Tart Cherry Juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Inhalatorial Sedation in Patient With Subarachnoid Hemorrhage (SAH) Versus Conventional Intravenous Sedation
Status: COMPLETED
Conditions: Stroke|Subarachnoid Hemorrhage
Interventions: DRUG: Propofol|DRUG: Isoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuroendocrine Mechanisms of Developmental Massage Therapy (DMT) in Preterm Infants: Clinical Study
Status: COMPLETED
Conditions: Premature Birth of Newborn
Interventions: OTHER: Developmental Massage Therapy|OTHER: no intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of CTX-009 in Combination With Paclitaxel in Adult Patients With Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers (COMPANION-002)
Status: ACTIVE_NOT_RECRUITING
Conditions: Biliary Tract Cancer|Cholangiocarcinoma|Gall Bladder Cancer|Ampullary Cancer
Interventions: DRUG: CTX-009|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HAIC Combined With Toripalimab and Donafenib for Advanced BTC
Status: ENROLLING_BY_INVITATION
Conditions: Biliary Tract Adenocarcinoma
Interventions: PROCEDURE: HAIC|DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Toripalimab|DRUG: Donafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Aripiprazole (Abilify) in Patients With Bipolar Mania
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Lithium or Valproate with placebo (PBO)|DRUG: Lithium or Valproate with Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Genetic Determinants of Amitriptyline Efficiency for Pain Treatment
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DRUG: Amitriptyline|DRUG: Tolterodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone in Total Knee and Total Hip Arthroplasty
Status: UNKNOWN
Conditions: Total Knee Arthroplasty|Total Hip Arthroplasty|Osteoarthritis
Interventions: DRUG: Dexamethasone|OTHER: 0.9% NaCl Placebo|DRUG: LIA Combination Mixture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I /II Study of the Protease Inhibitor Indinavir (MK-0639) in Children With HIV Infection
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome|HIV Infections
Interventions: DRUG: indinavir (MK-0639)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Combined Antioxidant Therapy Against Myocardial Reperfusion Injury. Phase I Study.
Status: COMPLETED
Conditions: Acute Myocardial Infarction|Ischemia-reperfusion Injury|Reperfusion Injury, Myocardial|Reperfusion Arrhythmias|Reperfusion Injury
Interventions: DRUG: Antioxidant therapy|DRUG: NaCl 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acute Effect of Functional Crackers on Postprandial Metabolism
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: OTHER: Functional crackers enriched with grape seed flour|OTHER: Functional crackers with 40% barley flour and enriched with β-glucans
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Cabozantinib and Temozolomide for the Treatment of Unresectable or Metastatic Leiomyosarcoma or Other Soft Tissue Sarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Leiomyosarcoma|Metastatic Soft Tissue Sarcoma|Stage III Uterine Corpus Leiomyosarcoma AJCC v8|Stage IIIA Uterine Corpus Leiomyosarcoma AJCC v8|Stage IIIB Uterine Corpus Leiomyosarcoma AJCC v8|Stage IIIC Uterine Corpus Leiomyosarcoma AJCC v8|Stage IV Uterine Corpus Leiomyosarcoma AJCC v8|Stage IVA Uterine Corpus Leiomyosarcoma AJCC v8|Stage IVB Uterine Corpus Leiomyosarcoma AJCC v8|Unresectable Leiomyosarcoma|Unresectable Soft Tissue Sarcoma
Interventions: DRUG: Cabozantinib|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry
Status: RECRUITING
Conditions: Gaucher Disease|Cerebroside Lipidosis Syndrome|Glucocerebrosidase Deficiency Disease|Glucosylceramide Beta-Glucosidase Deficiency Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Belatacept and Risk of Post-transplant Lymphoproliferative Disorder in US Renal Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplantation|Transplantation, Kidney
Interventions: DRUG: Calcineurin inhibitors (CNI)|DRUG: Belatacept
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Pharmacokinetics, Pharmacodynamics, and Safety of Rongliflozin in Type 2 Diabetic Subjects With Renal Impairment
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: pyroglutamate rongliflozin capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RTA 744 in Breast Cancer Patients With Progression of Previously Irradiated Brain Metastases
Status: TERMINATED
Conditions: Brain Metastases
Interventions: DRUG: berubicin hydrochloride (RTA 744)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ramucirumab Plus FOLFIRI Versus Ramucirumab Plus Paclitaxel in Patients With Advanced or Metastatic Gastric Cancer, Who Failed One Prior Line of Palliative Chemotherapy
Status: RECRUITING
Conditions: Advanced Gastric or EGJ Cancer
Interventions: DRUG: FOLFIRI|DRUG: Ramucirumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cultural Adaptation of EMDR for Major Depressive Disorder and Compaire Its Online and Face-to-Face Testing
Status: NOT_YET_RECRUITING
Conditions: Major Depressive Disorder
Interventions: OTHER: EMDR Psychotherapy|OTHER: Online EMDR Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Open-label Follow-up Trial of Fixed Dose Combination of Telmisartan + Hydrochlorothiazide in Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: telmisartan 80 mg + hydrochlorothiazide 25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of IV VTS-270 for Infantile Liver Disease Associated With Niemann-Pick Disease, Type C
Status: RECRUITING
Conditions: Niemann-Pick Disease, Type C
Interventions: DRUG: adrabetadex (2-Hydroxypropyl-Beta-Cyclodextrin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-Derived Stem Cell Therapy for Diabetic Kidney Disease
Status: TERMINATED
Conditions: Diabetic Kidney Disease|Diabetic Nephropathies|Diabetes Mellitus, Type 2|Diabetes Mellitus, Type 1|Chronic Kidney Disease|Diabetic Nephropathy Type 2|Kidney Failure|Kidney Insufficiency
Interventions: BIOLOGICAL: Autologous adipose-derived mesenchymal stem/stromal cells (MSC) Lower Dose|BIOLOGICAL: Autologous adipose-derived mesenchymal stem/stromal cells (MSC) Higher Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Disease
Status: COMPLETED
Conditions: Venous Insufficiency
Interventions: DEVICE: urea contained compressing stockings|DEVICE: compressing stockings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of the Lee Silverman Voice Treatment®-BIG Intervention in Stroke
Status: COMPLETED
Conditions: Chronic Stroke
Interventions: BEHAVIORAL: LSVT®BIG Intervention|BEHAVIORAL: Waitlist Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture Combined With Yanqing Zhitong Ointment Acupoint Application in Chronic Non-specific Low Back Pain
Status: UNKNOWN
Conditions: Non-specific Low Back Pain
Interventions: OTHER: Yanqing Zhitong Ointment Acupoint application|OTHER: placebo acupoint application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Omega-3 and Vitamin D Supplements in Childhood T1D
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: omega-3 supplementation|DRUG: Vitamin D supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE