pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Integrated Cognitive Behavioral Therapy (ICBT) for Posttraumatic Stress Disorder (PTSD) and Substance Use Disorders
Status: COMPLETED
Conditions: Stress Disorder, Post-Traumatic|Substance-Related Disorders
Interventions: BEHAVIORAL: Integrated Cognitive Behavioral Therapy|BEHAVIORAL: Treatment-as-usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing Dual-channel Transcranial Alternating Current Stimulations Targeting Negative Symptoms in Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia|Transcranial Alternating Current Stimulations|Negative Symptoms
Interventions: DEVICE: transcranial alternating current stimulation (NE Starstim)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Observational Study:Safety,Efficacy and Quality of Life of Patients With Atrial Fibrillation, Treated With Trombix®
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: Trombix® (Rivaroxaban)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Phosphatidylserine on Time Trial Performance in Trained Male Cyclists
Status: UNKNOWN
Conditions: The Focus of the Study is to Investigate the Effects of Phosphatidylserine Supplementation on Exercise Physiology and Cycling Time-trial Performance
Interventions: DIETARY_SUPPLEMENT: Phosphatidylserine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety, Tolerability, and Preliminary Efficacy of Soquelitinib in Participants With Moderate to Severe AD
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: Soquelitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Specific Anti-Toxoplasmatic Add-on Medication in Toxoplasma Gondii Seropositive Individuals With Schizophrenia or Major Depression
Status: COMPLETED
Conditions: Schizophrenia|Major Depression
Interventions: DRUG: daraprim|DRUG: pyrimethamine|DRUG: folinic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study Assessing the Safety and Effectiveness of IC2000 and SPY Fluorescence Imaging Systems (SPY-PHI) in the Visualization of Lymphatic Vessels and Identification of Lymph Nodes During Sentinel Lymph Node Biopsy in Subjects With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Lymph Node Mapping|Sentinel Lymph Node Biopsy
Interventions: COMBINATION_PRODUCT: IC2000 and SPY-PHI|COMBINATION_PRODUCT: Tc-99m radioactive colloid and Gamma Probe
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Endometrial and Sub-endometrial Vascularity Before and After PRP Infusion in Frozen Embryo Transfer Cycles
Status: UNKNOWN
Conditions: Frozen Embryo Transfer
Interventions: BIOLOGICAL: Platelet-rich plasma intrauterine infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Single-arm, Single-center, Open-label Phase II Study of Zanubrutinib Combined With R-CHOP/R-DHAP in Newly Diagnosed Mantle CellLymphoma Patients
Status: NOT_YET_RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Zanubrutinib and RCHOP/RDHAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of Dasatinib Tablet
Status: COMPLETED
Conditions: Leukemia, Myelogenous, Chronic
Interventions: DRUG: CTTQ Dasatinib tablet|DRUG: Sprycel Dasatinib tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Humanized 3F8 Monoclonal Antibody (Hu3F8) When Combined With Interleukin-2 in Patients With High-Risk Neuroblastoma and GD2-positive Solid Tumors
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: DRUG: 3F8 Monoclonal Antibody Combined with Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of 18F-PSMA-11 PET for Detection of Lesions in Iodine Refractory Thyroid Cancers
Status: COMPLETED
Conditions: Thyroid Cancer
Interventions: DIAGNOSTIC_TEST: PET/CT scan F18-PSMA-11
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial to Evaluate Safety and Efficacy of Vinorelbine With Metronomic Administration in Combination With Atezolizumab as Second-line Treatment for Patients With Stage IV Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Atezolizumab|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intracardiac Versus Transesophageal Echocardiography for Left Atrial Appendage Occlusion Combined With Radiofrequency Ablation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: LAAC combined with radiofrequency ablation group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Panitumumab, Gemcitabine and Carboplatin in Triple-Negative Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Panitumumab|DRUG: Carboplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NKG2D CAR-T Cell Therapy for Patients With Relapsed and/or Refractory Acute Myeloid Leukemia
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: NKG2D CAR T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Creatine Supplementation as Compared to Glucosamine/Chondroitin Sulfate Supplementation in Addition to Exercise and Physical Therapy in the Management of Knee Osteoarthritis.
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: Creatine Supplementation|DIETARY_SUPPLEMENT: Glucosamine and Chondroitin sulfate supplementation|OTHER: Supervised Exercise training|OTHER: Home Exercise Program|PROCEDURE: Electrotherapy + Heating|PROCEDURE: Joint Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safe and Effective Use of the Avonex® Single-Use Autoinjector in Multiple Sclerosis Subjects
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DEVICE: single-use autoinjector with a prefilled liquid Avonex syringe|DEVICE: Avonex prefilled syringe via manual IM injection|DRUG: BG9418 (interferon beta-1a)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Functional Muscle Characteristics and Cardio-respiratory Interaction in Patients With Fontan Palliation
Status: COMPLETED
Conditions: Patients
Interventions: OTHER: Incremental cycling test (ICT)|OTHER: Constant load cycling test (CET)|OTHER: Incremental respiratory muscle test (IncRMET)|OTHER: Incremental quadriceps muscle test (IncQMT)|OTHER: Respiratory muscle training like interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Microbiome and Malnutrition in Pregnancy
Status: RECRUITING
Conditions: Pregnancy Related|Pregnancy Loss|Pregnancy Complications|Pregnancy; Parasitic Disease|Microbial Colonization|Microbial Disease|Parasitic Disease|Metabolomics|Malnutrition|Malnutrition, Infant|Malnutrition Pregnancy|Breast Feeding
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chemotherapy Plus Radiation Therapy in Treating Patients With Unresectable, Residual, or Recurrent Colorectal Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: capecitabine|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Errector Spinae Plane Block for Postoperative Pain Management in Cardiac Surgery: A Randomized Controlled Trial
Status: UNKNOWN
Conditions: Erector Spinae Plane Block|Cardiac Surgery
Interventions: PROCEDURE: erector spinae plane block|DRUG: iv analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Acceptability and Efficacy of Pain Reprocessing Therapy in Racially/ Ethnically Diverse Adults With Chronic Back Pain
Status: RECRUITING
Conditions: Pain, Chronic|Back Pain
Interventions: BEHAVIORAL: Pain reprocessing therapy (PRT)|BEHAVIORAL: Cognitive Behavioral Therapy for Chronic Pain (CBT-CP)|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IS Metomidate PET-CT Superior to Adrenal Venous Sampling in Predicting Outcome From Adrenalectomy in Patients With Primary Hyperaldosteronism
Status: COMPLETED
Conditions: Primary Aldosteronism|Hyperaldosteronism
Interventions: PROCEDURE: adrenalectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safe Accelerated Venetoclax Escalation in CLL
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Venetoclax|DRUG: Obinutuzumab|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Treatment Regimen for Student Athletes With Mild to Moderate Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Adapalene/benzoyl peroxide gel, 0.1%/2.5%|OTHER: Cetaphil Acne Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of a Pre-Workout Supplement
Status: COMPLETED
Conditions: Exercise Ergogenics
Interventions: DIETARY_SUPPLEMENT: C4/Generation 4|DIETARY_SUPPLEMENT: C450X|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of 9-valent Extraintestinal Pathogenic Escherichia Coli Vaccine (ExPEC9V) and High-dose Quadrivalent Influenza Vaccine, With and Without Co-administration, in Adults Aged 65 Years or Older
Status: COMPLETED
Conditions: Invasive Extraintestinal Pathogenic Escherichia Coli Disease (IED) Prevention
Interventions: BIOLOGICAL: ExPEC9V|BIOLOGICAL: Placebo|BIOLOGICAL: HD quadrivalent influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Pharmacodynamic Study of ABT-436 in Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: ABT-436|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparision of Pharmacokinetic and Pharmacodynamic of Biocon Insulin N and Humulin® N
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: BIOLOGICAL: Biocon Insulin N|BIOLOGICAL: Humulin® N
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Furosemide vs Placebo for Brain Relaxation
Status: TERMINATED
Conditions: Brain Swelling|Brain Edema|Dehydration
Interventions: DRUG: Furosemide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Real-world Study on Adjuvant Octreotide Therapy in pNETs
Status: COMPLETED
Conditions: Pancreatic Neuroendocrine Tumor G2
Interventions: DRUG: Octreotide LAR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Clinical Investigation Evaluating the Safety and Performance of RGn550 in Treating Sportspeople Suffering From Acute Concussion Syndrome
Status: COMPLETED
Conditions: Acute Concussion Syndrome
Interventions: DEVICE: RGn550 5 Hz-PWM|DEVICE: RGn550 10 Hz-PWM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Exoskeleton Assistance for Individuals Post-Stroke
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: OTHER: Control|DEVICE: Hip Exoskeleton|DEVICE: Ankle Exoskeleton
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Anti Plaque Efficacy of Salvadora Persica L. and Green Tea Mouthwash
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: OTHER: Co.|OTHER: Kin|OTHER: Distilled water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Software Enhancements to the Respironics BiPAP autoSV Device Compared to BiPAP S/T Device
Status: TERMINATED
Conditions: Sleep Disordered Breathing
Interventions: DEVICE: BiPAP S/T|DEVICE: BiPAP Auto SV3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pasteurized; Pasteurized and Homogenized and UHT Treated Homogenized Cow's Milk on Gastrointestinal Symptoms in Sensitive Adults
Status: COMPLETED
Conditions: Unidentified Gastrointestinal Discomfort Following Dairy Consumption
Interventions: OTHER: Dietary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Tigulixostat on the Pharmacokinetics of Theophylline
Status: COMPLETED
Conditions: Gout|Hyperuricemia
Interventions: DRUG: Tigulixostat|DRUG: Theophylline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Intermittent Oro-Esophageal Tube Feeding in Infants With Cerebral Palsy and Dysphagia
Status: TERMINATED
Conditions: Cerebral Palsy
Interventions: BEHAVIORAL: systemic therapy|DEVICE: Intermittent Oro-Esophageal Tube Feeding|DEVICE: Persistent Nasogastric Tube Feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessing the Impact of Mobile Phone Technology to Improve Health Nutrition and Population (HNP) Service Utilization in Rural Bangladesh Through Pilot Intervention
Status: UNKNOWN
Conditions: Maternal Health|Child Health|Vaccination|Family Planning Services
Interventions: BEHAVIORAL: Impact of Mobile Phone Technology to Improve Health Nutrition and Population (HNP) Service Utilization in Rural Bangladesh
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: High-Dose Vitamin D3 Supplementation in the Treatment of Human Immune Deficiency Virus Patients Trial
Status: COMPLETED
Conditions: HIV-1-infection|Hypovitaminosis D
Interventions: OTHER: placebo Oil|DRUG: 25-Hydroxyvitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations
Status: ACTIVE_NOT_RECRUITING
Conditions: Urothelial Cancer
Interventions: DRUG: Erdafitinib|DRUG: Vinflunine|DRUG: Docetaxel|DRUG: Pembrolizumab|DEVICE: Fibroblast Growth Factor Receptor inhibitor Clinical Trial Assay (FGFRi CTA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Etanercept in Treating Cancer-Related Cachexia and Anorexia in Patients With Advanced Cancer
Status: COMPLETED
Conditions: Anorexia|Cachexia|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vaccine Immunotherapy for Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor
Status: ACTIVE_NOT_RECRUITING
Conditions: Medulloblastoma|Neuroectodermal Tumor
Interventions: BIOLOGICAL: TTRNA-xALT|BIOLOGICAL: TTRNA-DCs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Overuse of Antibiotics at Discharge Home
Status: ENROLLING_BY_INVITATION
Conditions: Pneumonia|Urinary Tract Infection|Antibiotic Stewardship|Care Transition
Interventions: OTHER: ROAD Home Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Staphylococcus Aureus Bacteremia Antibiotic Treatment Options
Status: COMPLETED
Conditions: Staphylococcus Aureus Infection
Interventions: DRUG: Trimethoprim-Sulfamethoxazole|DRUG: Clindamycin|DRUG: Linezolid|DRUG: Flucloxacillin|DRUG: Cloxacillin|DRUG: Vancomycin|DRUG: Daptomycin|DRUG: Cefazolin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetic Characteristics of HD203 Liq. in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Etanercept (Enbrel)|BIOLOGICAL: HD203
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GAIN Trial: Phase 2/3 Study of COR388 in Subjects With Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: COR388 capsule|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Durability of Hypertonic Saline for Enhancing Mucociliary Clearance in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: sodium chloride (7%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study for Evaluation of the Safety, Pharmacokinetics, and Antiviral Activity of UB-421 Subcutaneous Formulation Administered in HIV-1 Infected Treatment Naive Patients
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: BIOLOGICAL: UB-421 SC(dB4C7C22-6 mAb)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Topical Calcipotriol Versus Platelet-Rich Plasma
Status: COMPLETED
Conditions: Alopecia Areata
Interventions: DRUG: Calcipotriol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Could Medical Educational Video Reduce Anxiety Before Nasal Packing Removal After Septoplasty/Septorhinoplasty?
Status: UNKNOWN
Conditions: Septum Deviated|Septoplasty/Septorhinoplasty
Interventions: OTHER: medical educational video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Postoperative Pembrolizumab for the Patients Who Have Solid Predominant or Micropapillary Lung Adenocarcinoma With Pathologic Stage I and Primary Tumor Than 4 cm
Status: UNKNOWN
Conditions: Lung Adenocarcinoma, Stage I
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of QAX576 in Adults With Moderate Persistent Allergic Asthma
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: QAX576|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence of The Bowel, Bladder, and Sexual Dysfunction Following Surgery for Colorectal Malignancy
Status: COMPLETED
Conditions: Bowel Dysfunction|Bladder Dysfunction|Sexual Dysfunction|Colorectal Surgery
Interventions: PROCEDURE: Surgery for Colorectal malignant diseases either LAR or APR
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adipokines, Inflammation, Insulin Resistance and Endothelial Dysfunction in Preeclampsia
Status: COMPLETED
Conditions: Pre-Eclampsia
Interventions: DIAGNOSTIC_TEST: Serum asymmetteric dimethyl arginine|DIAGNOSTIC_TEST: serum lipid profiles|DIAGNOSTIC_TEST: Serum vaspin|DIAGNOSTIC_TEST: Serum resistin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Safety and Immunogenicity of Combined Immunization of PPV23 and IIV4
Status: COMPLETED
Conditions: Influenza, Human|Pneumonia, Pneumococcal
Interventions: BIOLOGICAL: IIV4 and PPV23|BIOLOGICAL: IIV4|BIOLOGICAL: PPV23
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Investigation of the Safety and Pharmacology of Dry Powder Inhalation of Treprostinil
Status: COMPLETED
Conditions: Primary Pulmonary Hypertension
Interventions: DRUG: LIQ861 Inhaled Treprostinil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Study Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1656 in Japanese Type 2 Diabetes Mellitus (T2DM) Patients
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: AZD1656|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Dosing, Effectiveness and Safety of Topiramate for the Treatment of Epilepsy
Status: COMPLETED
Conditions: Epilepsy|Seizures|Epilepsies, Partial|Epilepsy, Generalized|Seizures, Tonic-Clonic
Interventions: DRUG: Topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total Hip Arthroplasty (THA) Surgical Techniques Comparing the Direct Anterior Approach to the Posterior Approach
Status: COMPLETED
Conditions: Osteoarthritis of the Hip
Interventions: PROCEDURE: Anterior Approach / Posterior Approach|PROCEDURE: Anterior versus Posterior Approach for total hip replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iodine Supplementation in Obesity
Status: COMPLETED
Conditions: Iodine Deficiency|Subclinical Hypothyroidism
Interventions: DIETARY_SUPPLEMENT: Iodine tablet|DIETARY_SUPPLEMENT: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of the Vascular Closure Device (Tonbridge) in Hemostasis Treatment of Femoral Artery Puncture
Status: NOT_YET_RECRUITING
Conditions: Vascular Closure|Endovascular Procedure|Hemostasis|Femoral Artery|Puncture
Interventions: DEVICE: Vascular Closure Device (Tonbridge)|DEVICE: EXOSEAL Vascular Closure Device (Codis Corporation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Low Intensity, High Intensity Eccentric Resistance Training Associated With Blood Flow Restriction
Status: COMPLETED
Conditions: Exercise
Interventions: OTHER: High intensity eccentric training|OTHER: High intensity eccentric training with BFR|OTHER: Low intensity eccentric training with BFR|OTHER: Low intensity eccentric training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Short Term Safety and Efficacy of Lubiprostone in Adults With Cystic Fibrosis
Status: COMPLETED
Conditions: Constipation|Cystic Fibrosis
Interventions: DRUG: lubiprostone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SGM Evidenced-Based Mental Healthcare Implementation
Status: RECRUITING
Conditions: CBT|LGBTQ
Interventions: BEHAVIORAL: LGBTQ-Affirmative CBT Training: Materials Only|BEHAVIORAL: LGBTQ-Affirmative CBT Training: Direct Training|BEHAVIORAL: LGBTQ-Affirmative CBT Training: Local Supervision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact of Fluid Restriction Policy in Reducing the Use of Red Cells in Cardiac Surgery
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Artery Bypass|Erythrocyte Transfusion
Interventions: PROCEDURE: Fluid Restriction Policy|PROCEDURE: Free fluid infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Role of Adrenomedullin on the Outcome of Severe Heart Failure: a Clinical Randomized Study
Status: WITHDRAWN
Conditions: Heart Failure
Interventions: OTHER: clinical treatment|PROCEDURE: ultrafiltration|PROCEDURE: isovolumetric hemofiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PENG Block for Arthroscopic Hip Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Hip Arthroscopy
Interventions: PROCEDURE: Preop PENG block|PROCEDURE: Placebo block|DRUG: Ropivacaine 0.5% Injectable Solution|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Novel Sinusonic Device for Prevention of Community Acquired Upper Respiratory Infection (URI)
Status: COMPLETED
Conditions: Upper Respiratory Infection
Interventions: DEVICE: SinuSonic Device|DEVICE: Sham SinuSonic Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Extension Study of Etelcalcetide for Treatment of Secondary Hyperparathyroidism in Patients With Chronic Kidney Disease on Hemodialysis
Status: COMPLETED
Conditions: Hyperparathyroidism, Secondary
Interventions: DRUG: Etelcalcetide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Involvement of the Gut Hormone GIP in the Pathophysiology of Post Prandial Hypotension
Status: RECRUITING
Conditions: PostPrandial Hypotension
Interventions: OTHER: Intravenous infusion of GIPRA|OTHER: Intravenous infusion of saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Perioperative Patient Skin Antiseptic Preparation Evaluation
Status: COMPLETED
Conditions: Surgical Site Infection
Interventions: DRUG: 70% v/v Isopropyl Alcohol Surgical Solution|DRUG: 2%w/v Chlorhexidine Gluconate / 70% v/v Isopropyl Alcohol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: the Inhaled β2-adrenergic Receptor Agonist for Transient Tachypnoea of the Newborn (the REFSAL Trial)
Status: RECRUITING
Conditions: TTN|Respiratory Failure|PPHN
Interventions: DRUG: Salbutamol|DRUG: 0,9% Chloride Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Myocardial Protection With Adenosine During Primary Percutaneous Coronary Intervention in Pts With STEMI
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Adenosine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relation Between Nail Fold Capillaroscopy, Optical Coherence Tomography Angiography, and Femoral Vein Wall Thickness in Behçet's Disease Relation Between Nail Fold Capillaroscopy, Optical Coherence Tomography Angiography, and Femoral Vein Wall Thickness in Behçet's Disease
Status: NOT_YET_RECRUITING
Conditions: Behçet's Disease
Interventions: DEVICE: Nail Fold Capillaroscopy, Optical Coherence Tomography Angiography, and Femoral Vein Wall Thickness by U.S
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.
Status: RECRUITING
Conditions: Metastatic Melanoma|Unresectable Melanoma|Melanoma
Interventions: BIOLOGICAL: Lifileucel plus Pembrolizumab|BIOLOGICAL: Pembrolizumab with Optional Crossover Period
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-interventional, Post Marketing Surveillance Study of Xultophy™ (Insulin Degludec/Liraglutide) to Evaluate Long Term Safety and Efficacy in Patients With Type 2 Diabetes Mellitus in Routine Clinical Practice in India
Status: WITHDRAWN
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec/liraglutide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Efficacy of Triple Regimen Based on Clarithromycin VS Metronidazole in Children
Status: UNKNOWN
Conditions: H Pylori Gastritis
Interventions: DRUG: Clarithromycin+ Amoxicillin + Omeprazole|DRUG: Metronidazole +Amoxicillin + Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Efficacy and Safety of Choline Alfoscerate in Vascular Cognitive Impairment Patients
Status: NOT_YET_RECRUITING
Conditions: Vascular Cognitive Impairment
Interventions: DRUG: Choline Alfoscerate 400mg|DRUG: Placebo of Choline Alfoscerate 400mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coronary Crossing System in Patients With Coronary Chronic Total Occlusions
Status: RECRUITING
Conditions: Chronic Total Occlusion of Coronary Artery
Interventions: DEVICE: Coronary Crossing System of Shanghai MicroPort Rhythm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study on Safety of PEEK Knee Prosthesis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis of Knee|Osteoarthritis of the Knee
Interventions: DEVICE: PEEK Knee Prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Of Expectant Management In The Tubal Ectopic Pregnancy
Status: COMPLETED
Conditions: Ectopic Pregnancy
Interventions: DRUG: Methotrexate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Different Low Level Laser Therapy Sessions
Status: COMPLETED
Conditions: Myofascial Pain Syndrome
Interventions: DEVICE: 940-nm diode laser / one session|DEVICE: 940-nm diode laser / two session|DEVICE: 940-nm diode laser/ three session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of Brentuximab Vedotin Combined With Multi-Agent Chemotherapy for Hodgkin Lymphoma
Status: COMPLETED
Conditions: Disease, Hodgkin
Interventions: DRUG: brentuximab vedotin|DRUG: doxorubicin|DRUG: vinblastine|DRUG: dacarbazine|DRUG: bleomycin|DRUG: brentuximab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Punch Minigraft Versus Transverse Needling or Combination of Both in Treatment of Non-Segmental Vitiligo
Status: UNKNOWN
Conditions: Vitiligo
Interventions: PROCEDURE: Autologous punch mini grafts:|PROCEDURE: Transverse needling|PROCEDURE: Punch minigrafts followed by transverse needling|OTHER: Oral pulse steroid with narrow band
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Effects of Epicatechin and Quercetin Supplementation on Vascular Function and Blood Pressure (FLAVO)
Status: COMPLETED
Conditions: Hypertension|Endothelial Dysfunction
Interventions: DIETARY_SUPPLEMENT: Epicatechin|DIETARY_SUPPLEMENT: Quercetin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety Study of HLCM051(MultiStem®) for Pneumonic Acute Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Adult
Interventions: BIOLOGICAL: HLCM051
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AGuIX Gadolinium-based Nanoparticles in Combination With Chemoradiation and Brachytherapy
Status: UNKNOWN
Conditions: Gynecologic Cancer
Interventions: DRUG: Polysiloxane Gd-Chelates based nanoparticles (AGuIX)|RADIATION: External beam radiotherapy (EBRT)|RADIATION: Uterovaginal brachytherapy|DRUG: Chemotherapy (cisplatin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of AP214 Acetate in Patients Undergoing Cardiac Surgery
Status: COMPLETED
Conditions: Cardiac Surgery|Coronary Artery Bypass Grafting|Valve Surgery|Aortic Root or Ascending Aortic Aneurysm Repair Surgery
Interventions: DRUG: AP214|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Single Injection Adductor Canal Block Versus Continuous Adductor Canal Infusion for Total Knee Arthroplasty
Status: COMPLETED
Conditions: Total Knee Arthroplasty|Pain, Postoperative|Adductor Canal Block
Interventions: PROCEDURE: Multimodal Peripheral Nerve Block Injection|PROCEDURE: Single Shot Adductor Canal Block|DRUG: Initial Bolus|DRUG: Continuous infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Of Tranexamic Acıd Application Wıth Different Doses On Bleeding, Edema And Physician Comfort In Orthognathıc Surgery Patients
Status: COMPLETED
Conditions: Tranexamic Acid|Orthognathic Surgery|Edema|Bleeding
Interventions: DRUG: Tranexamic acid injection|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Determining the Mechanism of Myocardial Injury and Role of Coronary Disease in Type 2 Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction, Acute|Myocardial Ischemia|Myocardial Injury
Interventions: DIAGNOSTIC_TEST: Invasive coronary angiography|RADIATION: CT coronary angiography|DIAGNOSTIC_TEST: Cardiac MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 12 Weeks of Ledipasvir (LDV)/Sofosbuvir (SOF) With Weight-based Ribavirin vs. 24 Weeks of LDV/SOF
Status: TERMINATED
Conditions: HIV-1 Infection|Hepatitis C
Interventions: DRUG: Ledipasvir/sofosbuvir|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relaxation Training for People With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: BEHAVIORAL: Guided Relaxation Technique|OTHER: Documentary Movie
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Effect of WCK 5222 on the QT/QTc Interval in Healthy Volunteers
Status: COMPLETED
Conditions: QT/QTc Interval in Healthy Volunteers
Interventions: DRUG: WCK 5222|DRUG: IV placebo matched to WCK 5222 / Moxifloxacin IV solution|DRUG: Moxifloxacin 400-mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Use of Cheetah® Cardiac Monitoring System to Guide Discontinuation of Magnesium Sulfate in Women With Severe Preeclampsia
Status: COMPLETED
Conditions: Preeclampsia With Severe Features
Interventions: DEVICE: Cheetah® non-invasive cardiac monitoring system|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: ESK981 in Treating Patients With Metastatic Castrate-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Castration Levels of Testosterone|Castration-Resistant Prostate Carcinoma|Metastatic Prostate Carcinoma|PSA Progression|Stage IV Prostate Adenocarcinoma AJCC v7
Interventions: DRUG: ESK981
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Coffeeberry Extract on Skill Performance During Simulated Match Play in Academy Football Players
Status: COMPLETED
Conditions: Skill Performance|Soccer Performance|Coffeeberry Effects
Interventions: OTHER: Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: BAY38-9456 - Pivotal Trial for Diabetes Patient
Status: COMPLETED
Conditions: Erectile Dysfunction|Diabetes Mellitus
Interventions: DRUG: Levitra (Vardenafil, BAY38-9456)|DRUG: Levitra (Vardenafil, BAY38-9456)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Epicutaneous Cryoimmunotherapy Combined With Pembrolizumab for Cutaneous Metastatic Breast Cancer
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: DEVICE: Epicutaneous cryoimmunotherapy|DRUG: Topical imiquimod|DRUG: Pembrolizumab|OTHER: Dermatologic Quality of Life Index|OTHER: Functional Assessment of Cancer Therapy|DRUG: Intra-lesional GM-CSF|DEVICE: Cry-AC|PROCEDURE: Cutaneous tumor biopsy|PROCEDURE: Peripheral blood draw for research
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)
Status: ACTIVE_NOT_RECRUITING
Conditions: Small Cell Lung Cancer
Interventions: BIOLOGICAL: Pembrolizumab 200 mg|BIOLOGICAL: Pembrolizumab 400 mg|DRUG: Pembrolizumab placebo (saline)|DRUG: Pembrolizumab placebo (saline)|DRUG: Olaparib 300 mg BID|DRUG: Olaparib matching placebo|DRUG: Etoposide 100 mg/m^2|DRUG: Platinum, investigator's choice|RADIATION: Standard Thoracic Radiotherapy|RADIATION: Prophylactic Cranial Irradiation (PCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MUltiple Sclerosis and Extract of Cannabis (MUSEC) Study
Status: TERMINATED
Conditions: Muscle Spasticity
Interventions: DRUG: standardized cannabis extract|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ-73763989, JNJ-56136379, Nucleos(t)Ide Analogs, and Pegylated Interferon Alpha-2a in Virologically Suppressed Participants With Chronic Hepatitis B Virus Infection
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: JNJ-73763989|DRUG: Tenofovir disoproxil|DRUG: Tenofovir alafenamide (TAF)|DRUG: Entecavir (ETV) monohydrate|DRUG: PegIFN-alpha2a
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Atezolizumab With or Without Bevacizumab in Combination With Cisplatin Plus Gemcitabine in Patients With Untreated, Advanced Biliary Tract Cancer
Status: COMPLETED
Conditions: Biliary Tract Cancer
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab|OTHER: Placebo|DRUG: Cisplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cox-2 Inhibition in Radiation-induced Oral Mucositis
Status: COMPLETED
Conditions: Oral Mucositis
Interventions: DRUG: celecoxib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Probiotic Bacteria in Subjects With IBS or Functional Diarrhea/ Bloating
Status: COMPLETED
Conditions: Pain
Interventions: DIETARY_SUPPLEMENT: Probiotics - Lactobacillus and bifidobacterium|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Defibrotide Therapy for SARS-CoV2 (COVID-19) Acute Respiratory Distress Syndrome (ARDS)
Status: COMPLETED
Conditions: COVID|Sars-CoV2|COVID-19|Acute Respiratory Distress Syndrome
Interventions: DRUG: Defibrotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketamine vs Propofol for Sedation During Pediatric Bronchoscopy
Status: SUSPENDED
Conditions: Paediatric Flexible Bronchoscopy
Interventions: DRUG: Ketamine|DRUG: Propofol|DRUG: midazolam and atropine|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Infraclavicular And Supraclavicular Block
Status: UNKNOWN
Conditions: Anesthesia Conduction|Upper Extremity Surgery|Pain, Postoperative|Anesthesia and Analgesia|Nerve Block|Brachial Plexus Block
Interventions: DRUG: Bupivacaine HCl 0.5% Injectable Solution|DRUG: Prilocaine HCl 2% Injectable solution|DRUG: Adrenaline amp. 0.5 mg|PROCEDURE: Ultrasound guided supraclavicular block with coronal oblique method|PROCEDURE: Ultrasound guided lateral sagittal infraclavicular block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Phase II Study: Hemodynamic Tolerance and Anti-inflammatory Effects of Esmolol During the Treatment of Septic Shock
Status: ACTIVE_NOT_RECRUITING
Conditions: Septic Shock
Interventions: DRUG: Esmolol administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MYND&CO: Studio Pilota Dell'Evoluzione Della Salute Psico-fisica Della Donna in Gravidanza
Status: UNKNOWN
Conditions: Pregnancy|Mental Health Wellness 1
Interventions: BEHAVIORAL: Integrated approach to pregnancy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Chemotherapy Induced Painful Peripheral Neuropathy Ethosuximide (The CIN-E Study)
Status: COMPLETED
Conditions: Cancer|Peripheral Neuropathy
Interventions: DRUG: Ethosuximide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nicotine Treatment of Impulsivity in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: DRUG: nicotine patch|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT