pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Sofosbuvir Containing Regimens for the Treatment of Chronic HCV GT3 Infected Patients
Status: COMPLETED
Conditions: Chronic Hepatitis C Infection
Interventions: DRUG: sofosbuvir and daclatasvir|DRUG: ledipasvir/sofosbuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Reuteri in the Prevention of Antibiotic Associated-diarrhea and Clostridium Difficile
Status: COMPLETED
Conditions: Antibiotic-associated Diarrhea|Clostridium Difficile
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Samarium-153 With Neoadjuvant Hormonal and Radiation Therapy for Locally Advanced Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Samarium-153|DRUG: Total Androgen Suppression (TAS) with Bicalutamide|DRUG: Total androgen suppression (TAS) with Goserelin Acetate|DEVICE: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas
Status: RECRUITING
Conditions: Intracranial Meningioma|Recurrent Meningioma|NF2 Gene Mutation
Interventions: DRUG: Vismodegib|DRUG: FAK Inhibitor GSK2256098|DRUG: Capivasertib|DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: French Assessment of MRD by Liquid Biopsies in Stage III CRC Patients (FRENCH.MRD.CRC)
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer|Stage III Colon Cancer|Minimal Residual Disease|Liquid Biopsy
Interventions: BIOLOGICAL: Blood sample/lliquid biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Multicenter Study of the Efficacy and Safety of JZP-258 in the Treatment of Idiopathic Hypersomnia (IH) With an Open-label Safety Extension
Status: COMPLETED
Conditions: Idiopathic Hypersomnia
Interventions: DRUG: JZP-258|DRUG: Placebo Oral Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Erythropoietin (EPO) on the Transfusion Requirements of Very Low Birth Weight Infants
Status: COMPLETED
Conditions: Infant, Newborn|Infant, Low Birth Weight|Infant, Small for Gestational Age|Infant, Premature|Anemia, Neonatal
Interventions: DRUG: Erythropoietin|OTHER: Sham Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Centanafadine Efficacy and Safety as Monotherapy or as Adjunct to SSRI in Adults With Major Depressive Disorder
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DRUG: Centanafadine|DRUG: Escitalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Multivirus - Directed Cytotoxic T Lymphocytes (CTL)
Status: ACTIVE_NOT_RECRUITING
Conditions: EBV|CMV|Adenovirus
Interventions: DRUG: CTL for CMV seropositive donors|DRUG: CTL for CMV naïve donors
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Buprenorphine/Naloxone Administered in Different Ways For Treating Opioid Dependence
Status: COMPLETED
Conditions: Opioid-Related Disorders
Interventions: DRUG: Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Crohn's Disease Exclusion Diet With Partial Enteral Nutrition or Alone in Adult Patients With Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DIETARY_SUPPLEMENT: Crohns Disease Exclusion Diet + PEN|OTHER: Crohns Disease Exclusion Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Artificial Intelligence Based Program to Classify Oral Cavity Findings Based on Clinical Image Analysis
Status: NOT_YET_RECRUITING
Conditions: Oral Cancer|Oral Lichen Planus|Fordyce Granule|Leukoplakia|Erythroplakia|Leukoedemas, Oral|Lichenoid Reaction
Interventions: DIAGNOSTIC_TEST: Artificial intelligence based program
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Occurring After Total Knee Arthroplasty (TKA)
Status: RECRUITING
Conditions: Joint Infection
Interventions: DRUG: PLG0206
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benefit/Risk in Real Life of New Oral Anticoagulants and Vitamin K Antagonists in Patients Aged 80 Years and Over
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Direct oral antocoagulant: dabigatran, rivaroxaban, apixaban|DRUG: Vitamin K antagonist: warfarin, fluindione, acenocoumarol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ingenol Mebutate Gel, 0.015% Repeat Use for Multiple Actinic Keratoses on Face and Scalp
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Ingenol mebutate gel, 0.015%|DRUG: Vehicle gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Incidence of Hemorrhagic and Ischemic Events in Post-angioplasty in Anticoagulated Coronary Patients With Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation|Acute Coronary Syndrome|Thrombosis|Hemorrhage
Interventions: DIAGNOSTIC_TEST: Blood panel
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Impact of a Patient Education Intervention for Ambulatory Oncology Patients
Status: COMPLETED
Conditions: Gastro-intestinal Cancer|Lung Cancer|Head and Neck Cancer|Breast Cancer
Interventions: BEHAVIORAL: Instructed to read patient education pamphlets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Text Reminders to Immunize in a Managed Care Organization
Status: COMPLETED
Conditions: Human Papilloma Virus
Interventions: OTHER: Text-based reminder for recommended HPV vaccine or WCC|OTHER: Non-specific text-based reminder (general health tip)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Virtual Reality Glasses and Stress Ball Applications in Dressing Change
Status: NOT_YET_RECRUITING
Conditions: Surgical Wound|Abdominal Surgery
Interventions: DEVICE: Virtual Reality Glasses Group|DEVICE: Stress Ball Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Human Challenge With Live-attenuated Rotavirus to Assess Next-generation Rotavirus Vaccines in Africa
Status: UNKNOWN
Conditions: Diarrhea|Diarrhea Rotavirus
Interventions: BIOLOGICAL: Rotarix|BIOLOGICAL: Trivalent P2-VP8
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Does Simvastatin Affect Insulin Sensitivity in Dyslipidemic Type 2 Diabetic Patients?
Status: COMPLETED
Conditions: Hypercholesterolemia|Diabetes|Cardiovascular Disease
Interventions: DRUG: Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Statin Preloading in STEMI in Improving PCI Outcomes
Status: UNKNOWN
Conditions: ST Elevation Myocardial Infarction
Interventions: DRUG: Rosuvastatin 40mg|DRUG: Atorvastatin 80mg|DRUG: Control Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TDENV PIV and LAV Dengue Prime-boost Strategy
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: TDENV-LAV|BIOLOGICAL: TDENV-PIV 4 µg + alum adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ablation Guided Via Precision Imaging Using Electromechanical Wave Imaging
Status: NOT_YET_RECRUITING
Conditions: Arrhythmias, Cardiac
Interventions: DIAGNOSTIC_TEST: Electromechanical wave imaging (EWI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab and Combination Chemotherapy in Treating Participants With Diffuse Large B-Cell Lymphoma
Status: SUSPENDED
Conditions: Aggressive Non-Hodgkin Lymphoma|B-Cell Non-Hodgkin Lymphoma|CD20 Positive|Diffuse Large B-Cell Lymphoma Unclassifiable|Intravascular Large B-Cell Lymphoma|Primary Mediastinal (Thymic) Large B-Cell Lymphoma|T-Cell/Histiocyte-Rich Large B-Cell Lymphoma|Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Doxorubicin Hydrochloride|BIOLOGICAL: Nivolumab|DRUG: Prednisone|OTHER: Quality-of-Life Assessment|BIOLOGICAL: Rituximab|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of A-CP HA Kit, Hyaluronic Acid and Placebo for the Treatment of Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DEVICE: A-CP HA Kit|DEVICE: ArthroVisc 40|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Warfarin Prevents Portal Vein Thrombosis in Patients After Laparoscopic Splenectomy and Azygoportal Disconnection
Status: COMPLETED
Conditions: Cirrhosis|Hypertension|Status;Splenectomy|Venous Thrombosis
Interventions: DRUG: Warfarin|DRUG: Dipyridamole|DRUG: Aspirin|DRUG: Low Molecular Weight Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of the Safety, Tolerability and Pharmacokinetics of BILR 355 BS Plus Low Dose Ritonavir in HIV-uninfected Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BILR 355 BS, solution|DRUG: BILR 355 BS, tablet|DRUG: Ritonavir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of PTX+IFN Alpha+ RBV on Hepatitis C Virus Coinfected HIV Patients
Status: UNKNOWN
Conditions: Hepacivirus|HIV Infections
Interventions: DRUG: Pentoxifylline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Guys/Girls Opt for Activities for Life Trial (GOAL) to Increase Young Adolescents' Physical Activity and Healthy Eating
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity, Adolescent
Interventions: BEHAVIORAL: Guys/Girls Opt for Activities for Life (GOAL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Gamified Cognitive Control Training Using de:)Press on Depression Severity add-on to Treatment as Usual
Status: UNKNOWN
Conditions: Depression|Cognitive Impairment|Cognitive Dysfunction|Depressive Disorder
Interventions: BEHAVIORAL: de:)press
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders
Status: NOT_YET_RECRUITING
Conditions: Invasive PreNatal Diagnosis in a Context of Family History of Single-gene Disorders, Including|Sickle Cell Disease|Cystic Fibrosis|Fragile X Syndrome|Proximal Spinal Muscular Atrophy|Myotonic Dystrophy|Muscular Dystrophy, Duchenne|Muscular Dystrophy, Becker|Neurofibromatosis-Noonan Syndrome|Huntington Disease|Hemophilia A|Hemophilia B|MODY2 Diabetes|X-Linked Hydrocephalus|Autosomal Recessive Polycystic Kidney Disease
Interventions: BIOLOGICAL: Blood sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Supplementary Vitamins on Oxidant Gene Expression in the Lungs of Healthy Smokers
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DIETARY_SUPPLEMENT: Group 1|DIETARY_SUPPLEMENT: Group 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Nebulized Liposomal Amphotericin B Ambisome for Prophylaxis of Invasive Pulmonary Aspergillosis
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Allogeneic Haematopoietic Progenitor Cell Transplant
Interventions: DRUG: liposomal Amphotericine B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intravenous Lidocaine Infusion in the Management of Post-operative Pain in Colorectal Patients
Status: WITHDRAWN
Conditions: Colorectal Disorders
Interventions: DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-inferiority Evaluation of Pain Intensity After Biomatrop (Somatropin) Application in Relation to Hormotrop (Somatropin), in Healthy Subjects
Status: UNKNOWN
Conditions: Healthy Subjects
Interventions: DRUG: Recombinant human growth hormone - Biomatrop|DRUG: Recombinant human growth hormone - Hormotrop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Post-CA Neuroprotection With Magnesium
Status: NOT_YET_RECRUITING
Conditions: Cardiac Arrest|Return of Spontaneous Circulation
Interventions: DRUG: Magnesium Sulfate|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Behavioral Health Intervention Using Digital Technology in Radiation Therapy for Prostate Cancer Patients
Status: COMPLETED
Conditions: Prostate Cancer|Prostate Adenocarcinoma|Radiation Toxicity
Interventions: BEHAVIORAL: Smart Water Bottle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SEQ Block for Perioperative Analgesia in Acetabular Surgery
Status: COMPLETED
Conditions: Anesthesia, Local|Nerve Pain|Pain, Postoperative|Acetabular Fracture
Interventions: PROCEDURE: Single puncture combined lumbar erector spinae plane block and quadrates lumborum block|DRUG: Morphine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of Efficacy and Safety of add-on Alpha-lipoic Acid on Migraine Prophylaxis in Adolescent Population
Status: COMPLETED
Conditions: Adolescent Migraine
Interventions: DRUG: Flunarizine 5mg|DRUG: Alpha lipoic acid 300mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Response to Tyrosine Kinase Inhibitors in Localized Non-small Cell Lung Cancer (NSCLC) Patients With EGFR Mutation in a Patient-derived Organoid Model
Status: UNKNOWN
Conditions: Lung Cancer|Lung Adenocarcinoma|EGFR Activating Mutation|KRAS Mutation-Related Tumors|Non Small Cell Lung Cancer
Interventions: OTHER: Collection of surgical waste
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PSMA Guided Approach for bIoCHEmical Relapse After Prostatectomy-PSICHE
Status: RECRUITING
Conditions: Prostate Cancer|Biochemical Relapse Fo Malignant Neoplasm of Prostate|Prostate Adenocarcinoma|Prostate Cancer Recurrent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigation of Dietary Nitrate Effects in Hypertension-induced Target Organ Damage
Status: COMPLETED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 99mTc-H7ND SPECT/CT Imaging in NSCLC
Status: RECRUITING
Conditions: NSCLC
Interventions: DIAGNOSTIC_TEST: 99mTc-H7ND SPECT/CT imaging performed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nutritional Orientations and Adherence, Nutritional Status, Clinical and Life Quality Parameters of Heart Failure (HF) Patients
Status: COMPLETED
Conditions: Nutrition|Heart Failure
Interventions: BEHAVIORAL: Nutritional education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Immunogenicity of Hepatitis B Vaccination in Hemodialysis Patients
Status: COMPLETED
Conditions: Hepatitis B Vaccine
Interventions: BIOLOGICAL: 60 µg dose hepatitis B vaccine|BIOLOGICAL: 20 µg dose hepatitis B vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Remimazolam vs Sevoflurane Anesthesia on Incidence of Emergence Agitation and Complications in Children Undergoing Ophthalmic Surgery
Status: COMPLETED
Conditions: Emergence Agitation|Remimazolam|Sevoflurane|Pediatric Ophthalmic Surgery|Anesthesia, General
Interventions: DRUG: Remimazolam|DRUG: Sevoflurane|DRUG: Fentanyl|DRUG: Cisatracurium Besylate|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Immune Profile of Saliva and Serum of Patients With Primary Sjögren´s Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Sjogren's Syndrome
Interventions: PROCEDURE: Periodontal scaling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First-in-Human, Single- and Multiple-Ascending Dose Study of YH35995 in Healthy Adult Male Participants
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: YH35995|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Attenuation of Pain in Men and Women
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Naltrexone, then placebo|DRUG: Placebo, then Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Impact of Imprinting and Repeated Influenza Vaccination on Adaptive Immunity, Transcriptomics, and Metabolomics
Status: TERMINATED
Conditions: Influenza
Interventions: BIOLOGICAL: FLUARIX QUADRIVALENT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Treatment-free Remission in Chronic Phase Chronic Myeloid Leukemia
Status: NOT_YET_RECRUITING
Conditions: Chronic Myeloid Leukemia, Chronic Phase
Interventions: DRUG: Asciminib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combining Cognitive Training With tDCS to Enhance Memory Inhibition in Young Binge Drinkers
Status: COMPLETED
Conditions: Binge Drinking
Interventions: DEVICE: Active tDCS|DEVICE: Sham tDCS|BEHAVIORAL: Active CT|BEHAVIORAL: Sham CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Anlotinib Plus Penpulimab (AK105) for Chemo-refractory Metastatic Colorectal Cancer:ALTER-C003
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: Anlotinib|DRUG: Penpulimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Two Corneal Graft Storage Media: New Animal Compound Free Medium Versus Reference Medium
Status: COMPLETED
Conditions: Corneal Transplantation
Interventions: PROCEDURE: corneal graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Ingenol Mebutate Gel 0.015% & 0.05% in Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: ingenol mebutate gel 0.015%|DRUG: ingenol mebutate gel 0.05%
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Drug Interaction of PA-824, an Investigational Tuberculosis Medication, Together With Efavirenz, Ritonavir-Boosted Lopinavir, or Rifampin
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: PA-824|DRUG: Efavirenz (EFV)|DRUG: Lopinavir/Ritonavir (LPV/r)|DRUG: Rifampin (RIF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Vaccine Hesitancy Counseling Intervention for Pharmacists: A Stepped-Wedge Trial
Status: ENROLLING_BY_INVITATION
Conditions: COVID-19
Interventions: BEHAVIORAL: Standard implementation webinar and online training|BEHAVIORAL: Virtual facilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effects of DHA- and EPA-enriched Oils on Cognitive Function and Mood
Status: COMPLETED
Conditions: Cognitive Function
Interventions: DIETARY_SUPPLEMENT: 3 g PronovaPure 150:500 EE EU|DIETARY_SUPPLEMENT: 3 g PronovaPure 500:200 EE EU|DIETARY_SUPPLEMENT: 3 g Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Ketamine (Ketalar) on Intracranial Pressure
Status: UNKNOWN
Conditions: Traumatic Brain Injury|Intracranial Hypertension
Interventions: DRUG: Ketamine, effect on intracranial pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intracameral Versus Intravitreal Bevacizumab Injection in NVG: RCT
Status: UNKNOWN
Conditions: Glaucoma, Neovascular|Vascular Endothelial Growth Factor Overexpression
Interventions: PROCEDURE: Intracameral injection|PROCEDURE: Intravitreal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Evaluation of Eplivanserin in Children With Insomnia
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders
Interventions: DRUG: Eplivanserin (SR46349)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Praga Formulation in the Treatment of Neuropathic Pain
Status: RECRUITING
Conditions: Neuropathic Pain
Interventions: DRUG: Praga formulation|OTHER: Placebo pregabalin 75mg|OTHER: Placebo Pregabalin 150mg|DRUG: Pregabalin 75mg|DRUG: Pregabalin 150mg|OTHER: Placebo Praga formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Combined Use of Naloxone and Tramacet on Postop Analgesia in Elderly Patients Having Joint Replacement Surgery
Status: COMPLETED
Conditions: Hip Arthroplasty|Knee Arthroplasty|Spinal Anesthesia
Interventions: DRUG: tramacet, naloxone|DRUG: tramacet|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Psilocybin in Chronic Low Back Pain and Depression
Status: RECRUITING
Conditions: Chronic Low-back Pain|Depression
Interventions: DRUG: Psilocybin|DRUG: Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preclinical Imaging Biomarkers of Alzheimer's Disease Neuropathology in Young Adults With Youth-onset Diabetes: a Proof-of-concept Study
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2|Diabetes, Youth Onset
Interventions: DRUG: PI-2620 tracer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)?
Status: COMPLETED
Conditions: Inflammatory Rheumatism|Psoriatic Arthritis|Rheumatoid Arthritis
Interventions: DRUG: etanercept Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Drospirenone-ethinylestradiol and/or Metformin on Cardiovascular Risk in Hyperinsulinemic Women With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Metformin|DRUG: Yasmin;|DRUG: Metformin plus Yasmin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Impact of Fast Phenotypic Antimicrobial Susceptibility Testing on Patients With Gram-Negative Rod Bacteremia
Status: WITHDRAWN
Conditions: Gram-negative Bacteremia
Interventions: DIAGNOSTIC_TEST: Accelerate Pheno|DIAGNOSTIC_TEST: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Gait and Muscle Power Training for Children With Developmental Coordination Disorder
Status: UNKNOWN
Conditions: Developmental Coordination Disorder
Interventions: BEHAVIORAL: Rhythmical auditory stimulation gait training and muscle power training (RAS-MPT)|BEHAVIORAL: Rhythmical auditory stimulation gait training (RAS)|BEHAVIORAL: Muscle power training (MPT)|OTHER: Controls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Feasibility of Stimulation on the Lumbar Part of the Spinal Cord to Improve Mobility Recovery in Patients With Sub-acute Spinal Cord Injury
Status: WITHDRAWN
Conditions: Spinal Cord Injury
Interventions: DEVICE: STIMO-2 device implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of ALV003 for the Treatment of Celiac Disease
Status: COMPLETED
Conditions: Celiac Disease
Interventions: BIOLOGICAL: ALV003|BIOLOGICAL: ALV003 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetic Artery Obstruction: is it Possible to Reduce Ischemic Events With Cilostazol?
Status: COMPLETED
Conditions: Ischemic Stroke|Peripheral Artery Disease|Diabetes Mellitus, Type 2
Interventions: DRUG: Clopidogrel|DRUG: Cilostazol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: To Evaluate the Efficacy and Safety in Patients With Dyslipidemia and Hypertension
Status: COMPLETED
Conditions: Dyslipidemia|Hypertension
Interventions: DRUG: LivaloVA|DRUG: LivaloV|DRUG: VA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between Two Adjuvant Drugs to Bupivacaine for Post-operative Epidural Analgesia in Abdominal Surgeries
Status: UNKNOWN
Conditions: Epidural Analgesia
Interventions: DRUG: Control Analgesic regimen|DRUG: Fentanyl Analgesic regimen|DRUG: Dexmedetomidine Analgesic regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Local Retrospective Observational Study to Evaluate the Treatment Patterns of mCRPC Patients in Belgium Treated With Radium-223
Status: COMPLETED
Conditions: Prostatic Neoplasms, Castration-Resistant
Interventions: DRUG: Radium-223 (Xofigo, Bay88-8223)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot Study to Determine the Feasibility and Utility of Implementing of the Full Scale TOM Trial
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone 250 mg/salmeterol 50 mg|DRUG: Montelukast 10mg|DRUG: Theophylline 400 mg|DRUG: ipratropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Glucagon-Like Peptide-1 Receptor Agonist in the Treatment of Adult, Obesity-related, Symptomatic Asthma (GATA-3)
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: Semaglutide Pen Injector 2.4mg weekly|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Family Based Intervention to Reduce the Risk of Type 2 Diabetes in Children
Status: COMPLETED
Conditions: Pediatric Obesity|Type 2 Diabetes|Metabolic Syndrome
Interventions: BEHAVIORAL: Family Focused Lifestyle Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Efficacy of Molecular Diagnostic Method for AMR in ABOiKT
Status: ACTIVE_NOT_RECRUITING
Conditions: ABO Blood Type Incompatible Kidney Transplantation|Antibody-mediated Rejection
Interventions: DIAGNOSTIC_TEST: 5-gene classification model
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Probiotics Enhance the Treatment of PD-1 Inhibitors in Patients With Liver Cancer
Status: UNKNOWN
Conditions: Liver Cancer
Interventions: OTHER: M9|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bioresorbable Polymer ORSIRO Versus Durable Polymer RESOLUTE ONYX Stents
Status: UNKNOWN
Conditions: Coronary Artery Disease|Angina Pectoris|Unstable Angina Pectoris|Acute Coronary Syndrome|Coronary Stenosis|Coronary Restenosis
Interventions: DEVICE: Orsiro|DEVICE: Resolute Onyx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Oxytocin on Placebo Analgesia: an Experimental Study in Healthy Volunteers
Status: COMPLETED
Conditions: Mechanisms and Modulators of Placebo Analgesia in Healthy Volunteers
Interventions: DRUG: Oxytocin|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Folatescan (Technetium TC 99M EC20) in Patients With Suspected Ovarian Carcinoma or Recurrent Endometrial Carcinoma
Status: COMPLETED
Conditions: Ovarian Carcinoma|Recurrent Endometrial Carcinoma
Interventions: DRUG: Tc 99m EC20
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function
Status: TERMINATED
Conditions: Cerebral Small Vessel Diseases
Interventions: DRUG: Amlodipine|DRUG: Losartan|DRUG: Atenolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Carnitine on Oxidative Stress to IVIR Administration to CKD Patients:Impact of Haptoglobin Genotype
Status: UNKNOWN
Conditions: Anemia
Interventions: DRUG: L-Canitine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OCT-guided LALAK for KCN
Status: TERMINATED
Conditions: Corneal Opacity|Keratoconus
Interventions: PROCEDURE: LALAK|PROCEDURE: IEK|DRUG: Retrobulbar Block or General Anesthesia|DEVICE: optical coherence tomography (OCT)|DRUG: Topical Anesthesia|DEVICE: femtosecond laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DanceFit Prime: A Dance Based Physical Activity and Nutritional Intervention for Primary Care - A Feasibility Study
Status: COMPLETED
Conditions: Cardiac Diseases|Stroke|Diabetes Mellitus|Dementia|Mild Cognitive Impairment
Interventions: BEHAVIORAL: Facilitated group-based aerobic dance|BEHAVIORAL: Online, video prompted, individual aerobic dance|BEHAVIORAL: Facilitated group-based nutritional intervention|BEHAVIORAL: Self-paced online aerobic dance activity|BEHAVIORAL: Individual self-paced nutritional intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 1, Single Dose Study to Evaluate the Safety and Pharmacokinetics of MEDI0382 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: MEDI0382|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Epacadostat in Combination With Pembrolizumab and Chemotherapy in Participants With Advanced or Metastatic Solid Tumors (ECHO-207/KEYNOTE-723)
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: Epacadostat|DRUG: Pembrolizumab|DRUG: Oxaliplatin|DRUG: Leucovorin|DRUG: 5-Fluorouracil|DRUG: Gemcitabine|DRUG: nab-Paclitaxel|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Pemetrexed|DRUG: Cyclophosphamide|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: 5-Fluorouracil|DRUG: Investigator's choice of platinum agent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of BMS-986205 and Nivolumab in Endometrial Cancer or Endometrial Carcinosarcoma That Has Not Responded to Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Adenocarcinoma|Endometrial Carcinosarcoma
Interventions: DRUG: Nivolumab|DRUG: BMS- 986205
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Pharmacodynamic Profile of Insulin Lispro Using Needle-Free Jet Injection Technology
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Needle-free jet injection with insulin lispro|DEVICE: Conventional pen injection with insulin lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pulpal Complications in Posterior Resin Composite Restorations Without Glass-ionomer Cement Lining
Status: COMPLETED
Conditions: Dental Caries
Interventions: PROCEDURE: Glass ionomer cement lining
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Efficacy of Assisstive Tactile and Auditory Communicating Devices
Status: ACTIVE_NOT_RECRUITING
Conditions: Visual Impairment
Interventions: BEHAVIORAL: Standard object battery and training sequence|DEVICE: VIS4ION System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Evaluate Ultrasonic Surgical Aspiration as a Treatment Modality for Cervical Dysplasia
Status: COMPLETED
Conditions: Cervical Dysplasia
Interventions: PROCEDURE: cervical conization|PROCEDURE: ultrasonic surgical aspiration of the cervix
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Healthy Lifestyles for Mentally Ill People Who Have Experienced Weight Gain From Their Antipsychotic Medications - 2
Status: COMPLETED
Conditions: Diabetes|Obesity|Weight Gain
Interventions: BEHAVIORAL: Lifestyle Balance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: OnabotulinumtoxinA (onaBoNT-A) Versus Oral Oxybutynin ER
Status: UNKNOWN
Conditions: Overactive Bladder
Interventions: DRUG: onaBoNT-A|DRUG: Oxybutynin ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Enoblituzumab (MGA271) in Combination With Ipilimumab in Refractory Cancer
Status: COMPLETED
Conditions: Melanoma|Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: enoblituzumab plus ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Food Additives - Do Processed Diets Impact on Gut and Metabolic Health
Status: COMPLETED
Conditions: Gut Health|Metabolic Health
Interventions: DIETARY_SUPPLEMENT: Soya lecithin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: meChANisms and sAfety of SGLT2 Inhibition in peRitoneal dialYsis
Status: NOT_YET_RECRUITING
Conditions: Peritoneal Dialysis Complication|End Stage Kidney Disease|Sodium-glucose Co-transporter-2 Inhibitors|Kidney Dysfunction|Residual Kidney Function
Interventions: DRUG: Empagliflozin 25 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of AIN457 in Adults (18-65 Years) With Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: BIOLOGICAL: AIN457|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Wound Infiltration With Liposomal Bupivacaine vs. Standard Wound Infiltration With Bupivacaine in Patient's Undergoing Open Gynecologic Surgery on an Enhanced Recovery Pathway
Status: TERMINATED
Conditions: Malignant Neoplasms of Female Genital Organs|Gynecologic Cancer
Interventions: DRUG: Bupivacaine|DRUG: Liposomal Bupivacaine|DRUG: Oxycodone|BEHAVIORAL: Pill Diary|BEHAVIORAL: Symptom Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Hydration and Contrast-Induced Nephropathy in Primary Angioplasty
Status: COMPLETED
Conditions: Contrast Induced Nephropathy
Interventions: DRUG: sodium bicarbonate solution|DRUG: Isotonic saline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cerebral NIRS Monitoring During Anesthesia in Neonates and Infants
Status: UNKNOWN
Conditions: Cerebral Oxygenation
Interventions: DIAGNOSTIC_TEST: NIRS open
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Pancreatoduodenectomy in Pancreatic and Periampullary Tumors
Status: COMPLETED
Conditions: Pancreatic and Periampullary Tumors
Interventions: PROCEDURE: Superior mesenteric artery approach for pancreatoduodenectomy|PROCEDURE: Classic approach for pancreatoduodenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of SAD/MAD Oral Doses of SRP-3D (DA)
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain
Interventions: DRUG: SRP-3D (diethylamide)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of VEGF Trap in Patients With Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: VEGF Trap-Eye
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polatuzumab Vedotin Plus Rituximab, Ifosfamide, Carboplatin and Etoposide (Pola-R-ICE) Versus R-ICE Alone in Second Line Treatment of Diffuse Large B-cell Lymphoma (DLBCL)
Status: RECRUITING
Conditions: Relapsed Diffuse Large B-cell Lymphoma|Refractory Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Polatuzumab Vedotin|DRUG: Mabthera|DRUG: Ifosfamide|DRUG: Carboplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Fractional 1064-nm Picosecond Laser for Facial Skin Tightening
Status: RECRUITING
Conditions: Laxity; Skin
Interventions: DEVICE: StarWalker® PQX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy of Plant Sterol-Enriched Soymilk Versus Plain Soymilk in Volunteers With High LDL-Cholesterol
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: plant sterol and soluble fiber-enriched soymilk|DIETARY_SUPPLEMENT: soymilk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preliminary Evaluation of an Osteopathic Manipulative Treatment (OMT) to Prevent Motion Sickness Symptoms
Status: COMPLETED
Conditions: Motion Sickness
Interventions: OTHER: Osteopathic Manipulative Treatment|OTHER: Sham treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Graft-Versus-Host Disease in Treating Patients With Recurrent or Refractory Lymphoma or Hodgkin's Disease
Status: COMPLETED
Conditions: Graft Versus Host Disease|Lymphoma
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: recombinant interferon gamma|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: cyclosporine|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Trial on the Evaluation of Pylorus-ring in Pancreaticoduodenectomy
Status: COMPLETED
Conditions: Pancreatic Cancer|Bile Duct Cancer|Ampullary Cancer|Duodenal Cancer|Pancreatitis
Interventions: PROCEDURE: pylorus-preserving pancreaticoduodenectomy|PROCEDURE: pylorus-resecting pancreaticoduodenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief Cognitive Behavioral Therapy (CBT) for Pediatric Anxiety and Depression in Primary Care
Status: COMPLETED
Conditions: Anxiety|Depression
Interventions: BEHAVIORAL: Brief Cognitive Behavioral Therapy (BCBT)|BEHAVIORAL: Specialty mental health care referral (SMHC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) Trial
Status: UNKNOWN
Conditions: Microvascular Angina|Angina Pectoris|Angina, Stable|Non-Obstructive Coronary Atherosclerosis|Small Vessel Cerebrovascular Disease|Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: CMR results disclosed|DIAGNOSTIC_TEST: CMR performed but results not disclosed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC