pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Evaluate the Effect of Hepatic Impairment on JNJ-42847922 in Adult Participants
Status: COMPLETED
Conditions: Healthy|Hepatic Impairment
Interventions: DRUG: JNJ-42847922
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ARO-ANG3 in Healthy Volunteers and in Dyslipidemic Patients
Status: COMPLETED
Conditions: Dyslipidemias|Familial Hypercholesterolemia|Hypertriglyceridemia
Interventions: DRUG: ARO-ANG3|DRUG: sterile normal saline (0.9% NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy/Safety of Antibiotic Steroid Combination in Prevention of Post Operative Inflammation in LASIK Surgery
Status: COMPLETED
Conditions: Post Lasik Surgery Inflammation
Interventions: DRUG: antibiotic/steroid combination|DRUG: moxifloxacin/dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant PD-1 Inhibitor and EGFR Inhibitor in Locally Advanced Cutaneous Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Cutaneous Squamous Cell Carcinoma
Interventions: DRUG: Cetuximab|DRUG: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Non-surgical Periodontal Therapy Plus Doxycycline on HbA1c in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus With Periodontal Disease
Interventions: DRUG: Doxycycline Group|DRUG: placebo Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Storz Professional Image Enhancement System Versus White Light Imaging Assisted TURBT for Treatment of NMIBC
Status: UNKNOWN
Conditions: Bladder Urothelial Carcinoma|TURBT|Bladder Neoplasm|Cystoscopy
Interventions: PROCEDURE: SPIES assisted TURBT|PROCEDURE: WLI assisted TURBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study With an Open-label Extension Phase to Evaluate the Effect of Perampanel (E2007) on Cognition, Growth, Safety, Tolerability, and Pharmacokinetics in Adolescents
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Perampanel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Defining N-Acetyl Cysteine as a Treatment for Inhibiting Prurogenic Stimuli
Status: COMPLETED
Conditions: Pruritus|Skin Disorder
Interventions: DRUG: N-acetyl cysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic and Safety Study of Osmotic Release Oral System (OROS) Hydromorphone in Non-Opioid Tolerant Chinese Participants With Cancer
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Hydromorphone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Different Formulations of an A/H1N1 Pandemic Vaccine in Healthy Adults and the Elderly
Status: COMPLETED
Conditions: Influenza|Swine-origin A/H1N1 Influenza
Interventions: BIOLOGICAL: Monovalent Subvirion A/H1N1 Influenza vaccine (7.5 µg of HA)|BIOLOGICAL: Monovalent Subvirion A/H1N1 Influenza vaccine (15 µg of HA)|BIOLOGICAL: Monovalent Subvirion A/H1N1 Influenza vaccine (30 µg of HA)|BIOLOGICAL: Normal saline solution (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The NEU-STIM Trial
Status: NOT_YET_RECRUITING
Conditions: Infant, Premature, Diseases|Birth, Preterm
Interventions: PROCEDURE: Repeated tactile stimulation|PROCEDURE: Selective tactile stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NM-IL-12 (rHuIL-12) In Relapsed/Refractory Diffuse Large B- Cell Lymphoma (DLBCL) Undergoing Salvage Chemotherapy
Status: UNKNOWN
Conditions: Lymphoma, Large B-Cell, Diffuse (DLBCL)
Interventions: BIOLOGICAL: NM-IL-12
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coronary Artery Healing and Bioresorbable Scaffold
Status: UNKNOWN
Conditions: Myocardial Infarction|Coronary Artery Disease
Interventions: DEVICE: OCT guided PCI|DEVICE: Angiography guided PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ASP8825 - Pharmacokinetics Study in Patients With Impaired Renal Function and Haemodialysis
Status: COMPLETED
Conditions: Patients With Impaired Renal Function and Haemodialysis
Interventions: DRUG: ASP8825
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total Parenteral Nutrition Associated Cholestasis (TPNAC) and Plasma Amino Acid Levels in Neonates
Status: TERMINATED
Conditions: Premature Birth
Interventions: OTHER: Primene 10 % from Baxter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hmong Microbiome ANd Gout, Obesity, Vitamin C (HMANGO-C)
Status: COMPLETED
Conditions: Hyperuricemia|Gout
Interventions: DIETARY_SUPPLEMENT: Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Grappler® Interference Screw Post-Market Clinical Follow-Up Study
Status: COMPLETED
Conditions: Ankle Injuries|Syndesmotic Injuries|Ankle Inversion Sprain|Deltoid Ankle Sprain|Achilles Tendon Rupture|Flexor Hallucis Longus on the Left|Flexor Digitorum Longus on the Left|Ankle Sprains|Flexor Hallucis Longus on the Right|Flexor Digitorum Longus on the Right
Interventions: DEVICE: Grappler® Interference Screw System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Efficacy and Safety of SerpinPC in Participants With Severe Hemophilia A or Moderately Severe to Severe Hemophilia B
Status: RECRUITING
Conditions: Hemophilia A|Hemophilia B
Interventions: DRUG: SerpinPC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improvement of Planning Skills in Children and Adolescents With ADHD Through a Virtual Reality System: CogFun-RV
Status: NOT_YET_RECRUITING
Conditions: ADHD
Interventions: BEHAVIORAL: CogFun-RV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjunct Sedatives in Endoscopic Ultrasound (EUS) and Endoscopic Retrograde Cholangiopancreatography (ERCP) Procedures
Status: COMPLETED
Conditions: Endoscopic Ultrasound (EUS)|Endoscopic Retrograde Cholangiopancreatography (ERCP)
Interventions: DRUG: Meperidine, Midazolam|DRUG: Diphenhydramine|DRUG: Promethazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Assess the Safety and Tolerability of a PARP Inhibitor in Combination With Carboplatin and/or Paclitaxel
Status: COMPLETED
Conditions: Triple Negative Metastatic Breast Cancer|Advanced Ovarian Cancer|Carboplatin|Paclitaxel
Interventions: DRUG: KU-0059436 (AZD2281)(PARP inhibitor)|DRUG: Carboplatin|DRUG: KU-0059436 (AZD2281)(PARP inhibitor)|DRUG: Paclitaxel|DRUG: KU-0059436 (AZD2281)(PARP inhibitor)|DRUG: Paclitaxel + Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Epileptic Discharge on the Structural Connectivity of the Developing Brain
Status: RECRUITING
Conditions: Epilepsies, Focal|Pediatrics|Drug Resistant Epilepsy
Interventions: DEVICE: Electroencephalogram (EEG)|DEVICE: Diffusion Tensor imaging|OTHER: Language assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: BRII-196/BRII-198 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: BRII-196|BIOLOGICAL: BRII-198|BIOLOGICAL: Placebo|BIOLOGICAL: Remdesivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Significance of Latissimus Dorsi Flap Innervation in Delayed Breast Reconstruction
Status: COMPLETED
Conditions: Significance of Latissimus Dorsi Flap Innervation in Delayed Breast Reconstruction
Interventions: PROCEDURE: denervation of thoracodorsal nerve or saving the nerve
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy for Treatment of Cutaneous Squamous Cell Carcinoma in Situ
Status: UNKNOWN
Conditions: Squamous Cell Carcinoma
Interventions: DRUG: Levulan Kerastick|DEVICE: blue light source|OTHER: participant satisfaction survey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Social Cognition and Interaction Training for Improving Social Functioning in People With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Social cognition and interaction training (SCIT)|BEHAVIORAL: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Patients With Lesions in the Superficial Femoral and/ or Popliteal Arteries Using Kanshas Paclitaxel-coated Balloon Catheter.
Status: COMPLETED
Conditions: Femoropopliteal Occlusive Disease|Peripheral Artery Disease
Interventions: DEVICE: Kanshas DCB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of AVE5026 as Compared to Enoxaparin for the Prevention of Thromboembolism in Patients Undergoing Elective Knee Replacement Surgery
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: Semuloparin sodium|DRUG: Enoxaparin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Post Market Surveillance to Evaluate the Efficacy and Safety of the INDIGO Aspiration System in Japan
Status: RECRUITING
Conditions: Acute Limb Ischemia|Arterial Occlusion Mesenteric Artery Superior|Acute DVT of Lower Extremity
Interventions: DEVICE: Mechanical aspiration thrombectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Comparison of Microbial Adherence to Various Sutures in Patients Undergoing Oral Surgery
Status: UNKNOWN
Conditions: Oral Surgical Procedures
Interventions: OTHER: silk suture|OTHER: vicryl suture|OTHER: nylon suture|OTHER: polypropylene suture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Sequential GSK3228836 and Peginterferon Treatment in Participants With Chronic Hepatitis B (CHB)
Status: COMPLETED
Conditions: Hepatitis B
Interventions: DRUG: GSK3228836|DRUG: PegIFN|DRUG: NA therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined PECS II and Transversus Plane Blocks Versus Erector Spinae Block in Modified Radical Mastectomy
Status: COMPLETED
Conditions: Breast Cancer|Acute Postoperative Pain
Interventions: PROCEDURE: Combined Modified Pectoralis and Transversus Plane Blocks|PROCEDURE: Erector Spinae block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Biomarkers in Blood and Tissue Samples From Patients With Newly Diagnosed Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: GENETIC: RNA analysis|GENETIC: polymerase chain reaction|GENETIC: protein expression analysis|GENETIC: proteomic profiling|GENETIC: western blotting|OTHER: enzyme-linked immunosorbent assay|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|OTHER: liquid chromatography|OTHER: mass spectrometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Daratumumab, Ixazomib, & Dexamethasone or Daratumumab, Bortezomib, & Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Plasma Cell Myeloma
Interventions: DRUG: Bortezomib|BIOLOGICAL: Daratumumab|DRUG: Dexamethasone|DRUG: Ixazomib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Allograft Function and Histology Following Switching From A Tacrolimus to Sirolimus (SRL)-Based Immunosuppression-
Status: TERMINATED
Conditions: Kidney Transplant
Interventions: DRUG: Sirolimus|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess for Measurable Residual Disease (MRD) in Multiple Myeloma Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: OTHER: Screening Phase|DEVICE: Discontinuation Phase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase 3 Study of Obeticholic Acid in Patients With Primary Biliary Cirrhosis
Status: COMPLETED
Conditions: Primary Biliary Cirrhosis
Interventions: DRUG: Obeticholic Acid (OCA)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating TG4050 in Ovarian Carcinoma.
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Carcinoma|Fallopian Tube Cancer|Peritoneal Carcinoma
Interventions: DRUG: TG4050
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aspirin for the Prevention of Preeclampsia and Pregnancy Outcomes After Assisted Reproductive Technology
Status: RECRUITING
Conditions: ART|Pre-Eclampsia
Interventions: DRUG: Aspirin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Visualization Versus Intraoperative Neuromonitoring of the Recurrent Laryngeal Nerves in Thyroid Surgery
Status: COMPLETED
Conditions: Thyroid Surgery
Interventions: PROCEDURE: intraoperative RLN visualization|PROCEDURE: intraoperative neuromonitoring of the RLN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial to Evaluate ANT-1403 in the Treatment of Primary Axillary Hyperhidrosis
Status: COMPLETED
Conditions: Primary Axillary Hyperhidrosis
Interventions: BIOLOGICAL: ANT-1403|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Low Dose Prasugrel vs Clopidogrel for Stenting or Flow Diverter for Unruptured Aneurysm
Status: RECRUITING
Conditions: Intracranial Aneurysm
Interventions: DRUG: Prasugrel group|DRUG: Clopidogrel group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing the Affect of Bifeprunox Vs Olanzapine on Weight During the Treatment of Outpatients With Schizophrenia.
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: bifeprunox, olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study Evaluating the Efficacy of Enzalutamide and the Role of ARv7 in Metastatic Castration Resistant Prostate Cancer (mCRPC) Patients With Visceral Disease.
Status: COMPLETED
Conditions: Carcinoma Prostate
Interventions: DRUG: Xtandi
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Inflammatory Rheumatic Disease
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Systemic Lupus|Sjögren Syndrome|Systemic Vasculitis|Spondyloarthritis
Interventions: BIOLOGICAL: 13-valent pneumococcal conjugate vaccine|BIOLOGICAL: 23-valent pneumococcal polysaccharide vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Vitrification Versus Slow Freezing on Day 3: a Randomised Controlled Trial.
Status: COMPLETED
Conditions: Cryopreservation of Embryos
Interventions: OTHER: cryopreservation technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Treatment of Non-variceal Upper GI-bleeding With High Risk of Recurrency - OTSC (Over-the-scope-clip) Versus Standard Therapy (STING2)
Status: UNKNOWN
Conditions: Acute Upper Gastrointestinal Hemorrhage
Interventions: DEVICE: OTSC|DEVICE: Endoscopic Standard therapy (combining two methods)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation to Reduce Heroin Cravings
Status: COMPLETED
Conditions: Opioid-use Disorder|Heroin Abuse|Craving|Transcranial Magnetic Stimulation
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation|DEVICE: Sham Repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Ovarian Reserve After Conventional Laparoscopy Versus Robotic Surgery for Bilateral Endometrioma
Status: UNKNOWN
Conditions: Ovarian Endometrioma|Ovarian Endometriosis
Interventions: PROCEDURE: robotic-assisted laparoscopy|PROCEDURE: Conventional laparoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Baricitinib in New-onset Type 1 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 1 Diabetes
Interventions: DRUG: Baricitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: R-MTX-zanbrutinib in Secondary CNS Lymphoma
Status: UNKNOWN
Conditions: Secondary Central Nervous System Lymphoma
Interventions: DRUG: Zanubrutinib, high-dose methotrexate (HD-MTX), rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Cognitive and Laughter Therapy on Psychological Symptoms in Nursing Students
Status: COMPLETED
Conditions: Mental Health Issue
Interventions: BEHAVIORAL: CBT group|BEHAVIORAL: Laughter group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Recovery After Total Intravenous Anesthesia With Ketofol Versus Mixture of Ketofol and Lidocaine for Short Pediatric Surgery
Status: COMPLETED
Conditions: Surgical Procedure, Unspecified
Interventions: DRUG: ketamine, propofol|DRUG: ketamine, propofol, lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effect of Tablet-Based Games on Executive Functions in Older Adults With Mild Cognitive Impairment
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: OTHER: tablet (iPad or android) based role-playing game|OTHER: tablet (iPad or android) based word puzzles and image puzzles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized, Adaptive Treatment for Locally Advanced Head and Neck Cancer
Status: RECRUITING
Conditions: HPV-Negative Squamous Cell Carcinoma
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Cetuximab|RADIATION: Standard Dose Radiation|RADIATION: Low Dose Radiation|DRUG: Cisplatin|DRUG: TFHX Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: N-AcetylCysteine vs. Placebo to Prevent Neurotoxicity Induced by Platinum Containing Chemotherapy
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung|Carcinoma, Small Cell Lung|Mesothelioma
Interventions: DRUG: N-Acetylcysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Carbohydrate Metabolism Disorder Frequency in Hypertriglyceridemia Induced by Bexarotene of Cutaneous T Cell Lymphoma
Status: COMPLETED
Conditions: Hypertriglyceridemia|Cutaneous T Cell Lymphoma
Interventions: OTHER: oral glucose tolerance test (OGTT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of CC-122 in Combination With Nivolumab in Subjects With Unresectable Hepatocellular Carcinoma (HCC)
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: CC-122|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Motivational Interviewing to Promote Maintenance of Physical Activity in People With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Motivational interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Expiratory Muscle Conditioning in Multiple Sclerosis Using Magnetic Stimulation
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: OTHER: Functional Magnetic Stimulation|OTHER: Resistive Expiratory Muscle Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Asenapine With Placebo and Olanzapine (41022)(P05947)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: asenapine|DRUG: Placebo|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors and Risk of Cardiovascular Events
Status: COMPLETED
Conditions: Type2 Diabetes|Myocardial Infarction|Ischemic Stroke|Cardiovascular Death|Heart Failure|All-Cause Mortality
Interventions: DRUG: Sodium-glucose cotransporter 2 (SGLT2) inhibitors|DRUG: Dipeptidyl peptidase-4 (DPP-4) inhibitors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Group Culture in WOW Dishes of Human Embryos in Order to Optimize the Single Embryo Transfer (SET) Strategy.
Status: COMPLETED
Conditions: Fertility
Interventions: OTHER: control group|DEVICE: Primo Vision embryo culture dish (CE labeled, Vitrolife)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3, International, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Efficacy and Safety Trial of Linaclotide Administered Orally for 12 Weeks to Patients With Irritable Bowel Syndrome With Constipation (IBS-C)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Constipation (IBS-C)
Interventions: DRUG: Placebo|DRUG: Linaclotide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study To Assess the Safety and Tolerability of PBF-509 in Male Healthy Volunteers
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: PBF-509|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Support Program for Adoption of Cancer Screening Interventions at a Rural Community-Based Organization
Status: COMPLETED
Conditions: Breast Carcinoma|Cervical Carcinoma|Colorectal Carcinoma|Malignant Solid Neoplasm
Interventions: OTHER: Training|OTHER: Cancer Screening intervention|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of XL147 (SAR245408) in Advanced or Recurrent Endometrial Carcinoma
Status: COMPLETED
Conditions: Endometrial Cancer|Endometrial Neoplasms
Interventions: DRUG: XL147 (SAR245408)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of PNPLA3, TM6SF2 and MBOAT7 Genetic Variants on Non-alcoholic Fatty Liver Disease Therapeutic Outcome.
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease|Insulin Resistance
Interventions: DRUG: Nutraceutical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of CN-105 Neuroprotective Peptide for Intracerebral Hemorrhage
Status: COMPLETED
Conditions: Intracerebral Hemorrhage (ICH)
Interventions: DRUG: CN-105|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Operative Time During the Use of the Synthetic Glue IFABONDTM in Laparoscopic Sacrocolpopexy
Status: COMPLETED
Conditions: Prolapse
Interventions: DEVICE: Synthetic glue IfabondTM|PROCEDURE: Glue-Free Suture Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors
Status: RECRUITING
Conditions: Refractory Cancer|Recurrent Cancer|Solid Tumor, Adult|Cancer
Interventions: BIOLOGICAL: IMA203 Product|BIOLOGICAL: IMA203 product- flat dose|BIOLOGICAL: IMA203CD8 Product|DRUG: nivolumab (Opdivo®)|DEVICE: IMADetect®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study Between Concomitant Versus Load Therapy in Eradication of Helicobacter Pylori Infection
Status: COMPLETED
Conditions: H. Pylori Infection
Interventions: DRUG: Comparing Load and Concomitant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of REGN5093-M114 (METxMET Antibody-Drug Conjugate) in Adult Patients With Mesenchymal Epithelial Transition Factor (MET) Overexpressing Advanced Cancer
Status: RECRUITING
Conditions: Advanced NSCLC
Interventions: DRUG: REGN5093-M114|DRUG: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Abstention and Surveillance of Intra-epithelial Histological Lesions of High Grade Cervical CIN2 (Cervical Intraepithelial Neoplasia Grade 2). SUIVICIN
Status: RECRUITING
Conditions: HPV Infection|Cervical Cancer
Interventions: OTHER: abstention from CIN2 treatment and surveillance for at least 2 years
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessing Cost and Effectiveness of Training and Supervision of Front Line Workers on Early Breastfeeding Practices
Status: COMPLETED
Conditions: Malnutrition
Interventions: BEHAVIORAL: Improve Early Breastfeeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Placebo-Controlled, Phase 3 Study of Relugolix (TAK-385) 40 mg in the Treatment of Pain Symptoms Associated With Uterine Fibroids
Status: COMPLETED
Conditions: Uterine Fibroids
Interventions: DRUG: Relugolix|DRUG: Relugolix placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CBT Enriched With Emotion Regulation Training for Multiple Somatoform Symptoms (ENCERT) - A 3-year Follow-up
Status: UNKNOWN
Conditions: Somatic Symptom Disorder (DSM-5)
Interventions: BEHAVIORAL: Cognitive-behavioral therapy + emotion regulation training for patients with multiple somatoform symptoms|BEHAVIORAL: Cognitive-behavioral therapy for patients with multiple somatoform symptoms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Albumin-bound Paclitaxel/Granulocyte-based Therapy for Recurrent/Metastatic Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: BIOLOGICAL: Albumin paclitaxel/neutrophil drug
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temozolomide Plus Vorinostat in Relapse/Refractory Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia With 11q23-abnormality in Relapse
Interventions: DRUG: Temozolomide|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Autonomic Neural Blockade
Status: NOT_YET_RECRUITING
Conditions: Pain, Postoperative|Nausea, Postoperative|Vomiting, Postoperative|Analgesia|Opioid Use
Interventions: DRUG: Local anesthetic injection Bupivacaine plus dexamethasone|DRUG: Local anesthetic injection bupivacainde plus dexamethasone plus a colloid|DRUG: Local anesthetic injection bupivacaine plus clonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Trial of Cryotherapy Versus Caphosol Versus Saline Solution Mouth Washes for the Prevention of Oral Mucositis in Patients With Multiple Myeloma Undergoing Hematopoietic Stem Cell Transplantation
Status: COMPLETED
Conditions: Mucositis|Multiple Myeloma
Interventions: DRUG: 0.9% Sodium Chloride irrigation solution|OTHER: Cryotherapy (ice chips)|DEVICE: Calcium phosphate (Caphosol) Ca2+/PO43- mouth rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of The Relationship Between Drop in Hemoglobin and Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Copegus (Ribavirin) and Pegasys (Peginterferon Alfa-2a)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: peginterferon alfa-2a [Pegasys]|DRUG: ribavirin [Copegus]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dose Intensity Modulated Proton Radiation Treatment +/- Surgical Resection of Sarcomas of the Spine, Sacrum and Base of Skull
Status: ACTIVE_NOT_RECRUITING
Conditions: Chordoma of Spine|Chordoma of Sacrum|Chordoma of Base of Skull|Chondrosarcoma of the Spine|Chondrosarcoma of the Sacrum
Interventions: RADIATION: High Dose Intensity Modulated Proton Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Major Depressive Disorder Post Stroke With Transcranial Direct Current Stimulation
Status: COMPLETED
Conditions: Major Depressive Disorder 1
Interventions: DEVICE: Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Early and Partial Weight-bearing After Hallux Valgus Surgery
Status: RECRUITING
Conditions: Hallux Valgus|Orthopedic Disorder
Interventions: OTHER: Partial weight-bearing (10 - 15kg)|OTHER: Complete weight-bearing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate DD01 in Overweight/Obese Subjects With MASLD/MASH
Status: RECRUITING
Conditions: NAFLD|NASH
Interventions: DRUG: DD01|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ATS907 Ph2a Open-Label Dose-ranging Safety and Tolerability in Primary Open Angle Glaucoma (POAG) and Ocular Hypertension (OHT) Subjects
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: ATS907
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Doxil, Vincristine and Decadron (DVd) +/ CC-5013 in Relapsed Refractory Multiple Myeloma (MM)
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: CC-5013
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation (TMS) for Primary Progressive Apraxia of Speech (PPAOS)
Status: TERMINATED
Conditions: Apraxia Speech
Interventions: DEVICE: Transcranial Magnetic Stimulation (TMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of Zinc in Reducing Hyperbilirubinemia Among High Risk Neonates - A Double Blind Randomized Trial
Status: COMPLETED
Conditions: Neonatal Jaundice
Interventions: DRUG: zinc gluconate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Communication During Hospitalization About Resuscitation Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Severe Life-limiting COPD|Severe Life-limiting Heart Failure|Severe Life-limiting Cirrhosis|Severe Life-limiting Malignancy|Severe Functional Impairment|End Stage Renal Disease
Interventions: BEHAVIORAL: Informed Assent Discussion|BEHAVIORAL: Usual Care with Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC
Status: RECRUITING
Conditions: Arrhythmogenic Right Ventricular Cardiomyopathy
Interventions: GENETIC: TN-401
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypothermia to Prevent High Intracranial Pressure in Patients With Acute Liver Failure
Status: COMPLETED
Conditions: Acute Liver Failure|Intracranial Hypertension
Interventions: DEVICE: Hypothermia by the use of Blanketrol II, Cincinnati Sub-Zero
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compliance and Tolerability of Rivastigmine Transdermal Patch 10 cm² in Patients With Probable Alzheimer's Disease.
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Rivastigmine transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Binaural Beats on Level of Anxiety and Toleration in Patients Undergoing Upper Gastrointestinal Endoscopy Without Sedation
Status: COMPLETED
Conditions: Patient Satisfaction|Anxiety State|Tolerance
Interventions: OTHER: binaural music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Responding With Evidence and Access for Childhood Headaches
Status: RECRUITING
Conditions: Headache|Headache Disorders|Headache, Migraine|Migraine|Migraine Disorders|Migraine With Aura|Migraine Without Aura|Chronic Migraine
Interventions: BEHAVIORAL: CBT|DRUG: Amitriptyline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Donor Natural Killer Cells After Donor Stem Cell Transplant in Treating Patients With Advanced Cancer
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Lymphoproliferative Disorder|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: donor natural killer cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Umbilical Cord Blood vs Personalized Treatments for Improving Autistic Disorder
Status: COMPLETED
Conditions: Autistic Spectrum Disorder
Interventions: DRUG: Intranasal oxytocin|BIOLOGICAL: Autologous umbilical cord blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Fluid Therapy on Respiratory Mechanics
Status: UNKNOWN
Conditions: Mechanical Ventilation Complication|Actual Impaired Fluid Volume
Interventions: DRUG: Group Colloid|DRUG: Cristalloid administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Telephone-delievered Intervention to Reduce Methamphetamine Use
Status: COMPLETED
Conditions: Methamphetamine Use Disorder
Interventions: BEHAVIORAL: R2C-M|OTHER: Self-help booklet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Beetroot Juice to Protect Against Postoperative Ileus Following Colorectal Surgery: BEET IT Study
Status: RECRUITING
Conditions: Postoperative Ileus
Interventions: DIETARY_SUPPLEMENT: concentrated beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Ipatasertib in Combination With Paclitaxel as a Treatment for Participants With PIK3CA/AKT1/PTEN-Altered, Locally Advanced or Metastatic, Triple-Negative Breast Cancer or Hormone Receptor-Positive, HER2-Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Ipatasertib|DRUG: Paclitaxel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ALND Vs ART in Positive Sentinel Node After Neoadjuvant Therapy in Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Chemotherapy|Sentinel Lymph Node|Axillary Lymph Nodes Dissection|Radiotherapy Side Effect
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy of MK0719 in the Prevention of Postoperative Dental Pain (0719-002)
Status: TERMINATED
Conditions: Pain, Postoperative
Interventions: DRUG: MK0719
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Controlled Trial of Erenumab in Migraine Prevention
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Erenumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Panitumumab-IRDye800 in Detecting Cancer in Participants With Lung Cancer During Surgery
Status: RECRUITING
Conditions: Lung Carcinoma|Metastatic Malignant Neoplasm in the Lung|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: PROCEDURE: Near-Infrared Fluorescence Imaging|DRUG: Panitumumab-IRDye800|OTHER: Pharmacokinetic Study|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: AVI Didactic Experience for Latinx Patient Treatment Adherence and Non-English Speaker Trial Enrollment Study in Rad Onc
Status: RECRUITING
Conditions: Breast Cancer Invasive|Prostate Cancer
Interventions: OTHER: Audiovisual Intervention- Radiation Therapy Education|OTHER: ASTRO Radiation Therapy for Breast or Prostate Cancer Brochure|OTHER: Audiovisual Intervention- Cancer Clinical Trials Education|OTHER: NCI Taking Part in Cancer Research Studies Brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Steroid Injections in a Knee With Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis (OA) of the Knee
Interventions: DRUG: Triamcinolone Acetonide|DRUG: 0.9% Sodium Chloride Injection as Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Output Monitoring With Estimated Continuous Cardiac Output (esCCO) vs. Transpulmonary Thermodilution (TPTD)
Status: COMPLETED
Conditions: Pulse Wave Analysis
Interventions: OTHER: Fluid responsiveness tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Procedural Motor Memory in Long COVID-19
Status: RECRUITING
Conditions: Infectious Metabolic Encephalopathy|Ischemic Stroke|Seizure|Viral Encephalitis, Small and Large Vessel
Interventions: BEHAVIORAL: keypresses
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: the Phenotypic and Genetic Profile of Patients With Early Onset Schizophrenia Associated With Autism Spectrum Disorder.
Status: COMPLETED
Conditions: Schizophrenia|Dissociative Disorders
Interventions: OTHER: genetic and phenotypic profile
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Transcutaneous Electrical Nerve Stimulator to Improve Blood Glucose Control in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DEVICE: Transcutaneous Electrical Nerve Stimulator (DW1330)|DEVICE: Sham DW1330 device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Open-label, Multi-center, International, Three-year, Safety and Tolerability 'Follow on' Trial
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Technosphere® Insulin Inhalation Powder and MedTone™ Inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Multidisciplinary End-of-treatment Day Hospital on the Quality of Life of Adolescents and Young Adults With Cancer
Status: RECRUITING
Conditions: Solid Tumor|Lymphoma
Interventions: OTHER: Multidisciplinary day hospitalization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Nano Care Gold on Marginal Integrity of Resin Composite
Status: COMPLETED
Conditions: Caries Class Ii
Interventions: OTHER: Nano Care Gold|OTHER: No intervention|OTHER: Chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Theta Deep Brain Stimulation for Cognitive Enhancement in Parkinson's Disease
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease|Cognitive Impairment
Interventions: DEVICE: DBS On|DEVICE: DBS Off
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT