pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Early Virtual Intervention for Infants With CP Following HIE Diagnosis
Status: NOT_YET_RECRUITING
Conditions: Cerebral Palsy|Hypoxic-Ischemic Encephalopathy|Brain Injuries|Perinatal Hypoxia
Interventions: BEHAVIORAL: Virtual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase II Study of Doxorubicin, Cyclophosphamide and Vindesine With Valproic Acid in Patients With Refractory or Relapsing Small Cell Lung Cancer After Platinum Derivatives and Etoposide
Status: COMPLETED
Conditions: Small Cell Lung Carcinoma
Interventions: DRUG: Adriamycin, cyclophosphamide, vindesine, valproic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ceftobiprole in the Treatment of Pediatric Patients With Pneumonia
Status: COMPLETED
Conditions: Community-acquired Pneumonia (CAP)|Hospital-acquired Pneumonia (HAP)
Interventions: DRUG: ceftobiprole medocaril|DRUG: IV standard-of-care cephalosporin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketorolac-an Option for Post Operative Pain Management After Elective Cardiac Surgery.
Status: COMPLETED
Conditions: Coronary Artery Disease|Post Operative Pain|Analgesia|Coronary Artery Bypass Grafting Surgery
Interventions: DRUG: Ketorolac Injection|DRUG: Paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: S0801 Iodine I 131 Tositumomab, Rituximab, and Combination Chemotherapy in Previously Untreated Stage II, Stage III, or Stage IV Follicular Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|BIOLOGICAL: tositumomab|DRUG: cyclophosphamide|DRUG: doxorubicin|DRUG: prednisone|DRUG: vincristine|RADIATION: tositumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examination of Short and Long Term Complications of Thermocautery, Plastic Clamping and Surgical Circumcision Techniques
Status: COMPLETED
Conditions: Circumcision, Male
Interventions: DEVICE: Thermocautery|DEVICE: Plastic Clamping|DEVICE: Surgical Circumcision
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Suture Material on Postoperative Nipple Areolar Complex Widening
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Gynecomastia|Transgenderism|Breast Asymmetry
Interventions: PROCEDURE: Breast surgery|DEVICE: Suturing of surgical incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Exercise Application in the Treatment of Patients With Subacromial Pain Syndrome
Status: COMPLETED
Conditions: Shoulder Impingement Syndrome
Interventions: OTHER: Scapula-focused exercises|OTHER: Motor control exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Losartan Potassium and Hydrochlorothiazide (100 mg / 25 mg Tablet) [Test Formulation, Torrent Pharmaceuticals Ltd., India] Versus Hyzaar® (100 mg / 25 mg Tablet) [Reference Formulation, Merck & Co., Inc., USA] in Healthy Human Volunteers Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Losartan Potassium and Hydrochlorothiazide Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Phase Ib Trial of Multivalent Autophagosome Vaccine With or Without GITR Agonist, With Anti-PD-1 Immunotherapy in HNSCC
Status: RECRUITING
Conditions: Cancer of the Head and Neck
Interventions: DRUG: INCAGN01876|DRUG: INCMGA00012|BIOLOGICAL: DPV-001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mitomycin C Therapy for Patients With Primary Sclerosing Cholangitis
Status: UNKNOWN
Conditions: Primary Sclerosing Cholangitis
Interventions: DRUG: Mitomycin C|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Cannabis for the Prophylactic Treatment of Migraine
Status: NOT_YET_RECRUITING
Conditions: Chronic Migraine
Interventions: DRUG: CBD 100 mg OD|DRUG: CBD 200 mg OD|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Additional Self-care Acupressure for Women With Menstrual Pain Compared to Usual Care Alone
Status: COMPLETED
Conditions: Menstrual Pain
Interventions: PROCEDURE: Self-care acupressure at three predefined points
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Local Dry Cold, Hot and Vibration Applications in Peripheral Intravenous Catheterization
Status: COMPLETED
Conditions: Pain Management|Emergency Unit|Diarrhea|Nausea|Vomiting
Interventions: OTHER: Cold Application|OTHER: Heat Application|OTHER: Vibration Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Comparison of Ranibizumab and Aflibercept for the Development of Geographic Atrophy in (Wet) AMD Patients
Status: COMPLETED
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: Ranibizumab 0.5 mg|DRUG: Aflibercept 2.0 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Curosurf and Infasurf in the Treatment of Preterm Infants With Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Respiratory Distress Syndrome
Interventions: DRUG: Poractant alfa|DRUG: calfactant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-tumor Effect of Ixabepilone in Metastatic Breast Cancer (mBC) Selected by the Ixabepilone DRP.
Status: RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Ixabepilone Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Gonadotropin-releasing-hormone Agonist (GnRH-a) or Expectant Management for Endometriosis
Status: UNKNOWN
Conditions: Endometriosis
Interventions: DRUG: gonadotropin-releasing-hormone agonist (GnRHa) - Goserelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Low-Level Laser Therapy: an Efficient Supplement to Treatments of Vulvar Lichen Sclerosus to Improve Quality of Life
Status: COMPLETED
Conditions: Quality of Life
Interventions: DEVICE: EasyLaser: Low Level Laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Stellate Ganglion Block in Individuals With Parkinson's Disease
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: PROCEDURE: Injection|DRUG: Lidocaine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Blanketrol III and Arctic Sun in Cooling Non-shivering Humans
Status: COMPLETED
Conditions: Body Temperature Changes
Interventions: DEVICE: Blanketrol cooling device and water-perfused blankets|DEVICE: Blanketrol and Kool Kit|DEVICE: Arctic Sun
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supervised Treadmill Intervention to Reduce Inflammation and Depression Through Exercise in HIV: The STRIDE Pilot Study
Status: RECRUITING
Conditions: Depression|Hiv
Interventions: BEHAVIORAL: upfront advice to walk|BEHAVIORAL: Supervised exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pilot Study of Irreversible Electroporation (IRE) to Treat Metastatic Liver Cancer & Cholangiocarcinoma
Status: UNKNOWN
Conditions: Metastatic Liver Cancer|Cholangiocarcinoma|Neoplasm Metastasis
Interventions: PROCEDURE: Irreversible electroporation (IRE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Antibody Persistence at Eighteen Months After the Completion of the Vaccination Course in Study V72P10
Status: COMPLETED
Conditions: Meningococcal Disease|Meningococcal Meningitis
Interventions: BIOLOGICAL: No Vaccine|BIOLOGICAL: rMenB+OMV-NZ
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The isCGM Use and Hypoglycemic Episodes and Fear of Hypoglycemia in Newly Diagnosed Type 1 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1
Interventions: DEVICE: Intermittently Scanned Continuous Glucose Monitoring|DEVICE: Standard Blood Glucose Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PREDnisolone-induced Beta-cell Dysfunction Prevented by EXenatide
Status: COMPLETED
Conditions: Glucocorticoid-induced Glucometabolic Abnormalities|Glucocorticoid-induced Beta-cell Dysfunction
Interventions: DRUG: Placebo|DRUG: Prednisolone|DRUG: Prednisolone and Exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of a Micro-Implantable Pulse Generator for the Treatment of Peripheral Neuropathic Pain (COMFORT 2)
Status: RECRUITING
Conditions: Peripheral Neuralgia|Peripheral Neuropathy|Chronic Pain
Interventions: DEVICE: Nalu Neurostimulation System for PNS|OTHER: Conventional Medical Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intersphincteric Approach to Perianal Fistula With High Risk for Postoperative Fecal Incontinence
Status: COMPLETED
Conditions: High Transsphincteric Perianal Fistula
Interventions: PROCEDURE: Rerouting technique for transsphincteric perianal fistula
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Treatment of Pulmonary Embolism With Drotrecogin Alfa (Activated): Phase II Exploratory Study
Status: COMPLETED
Conditions: Submassive Pulmonary Embolism
Interventions: DRUG: Drotrecogin Alfa (Activated)|DRUG: Enoxaparin|DRUG: Placebo|DRUG: Drotrecogin Alfa (Activated)|DRUG: Drotrecogin Alfa (Activated)|DRUG: Drotrecogin Alfa (Activated)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Doxycycline in Combination With Interferon-B-1a to Treat Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Interferon beta 1a, oral doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduction of SystemiC Inflammation After Ischemic Stroke by Intravenous DNase Administration (ReSCInD)
Status: NOT_YET_RECRUITING
Conditions: Ischemic Stroke|Inflammatory Response
Interventions: DRUG: Dornase Alfa|DRUG: Isotonic Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Negative Pressure Incisional Wound Therapy for High-risk Ventral Hernia Repair
Status: COMPLETED
Conditions: Ventral Hernia
Interventions: DEVICE: Negative pressure incisional wound therapy|DEVICE: Standard sterile dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Etoricoxib Prescribing Patterns and Adverse Events of Interest in Primary Care in the United Kingdom (MK-0663-162 AM1)
Status: COMPLETED
Conditions: Osteoarthritis|Rheumatoid Arthritis|Ankylosing Spondylitis|Gout|Arthritis
Interventions: DRUG: Etoricoxib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nal-iri/lv5-fu Versus Paclitaxel as Second Line Therapy in Patients With Metastatic Oesophageal Squamous Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Squamous Cell Carcinoma
Interventions: DRUG: Onivyde|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Leucettinib-21 First-in-Human Phase 1 in Healthy Volunteers and Subjects With Down Syndrome and Alzheimer's Disease
Status: RECRUITING
Conditions: Healthy Volunteers|Down Syndrome|Alzheimer's Disease
Interventions: DRUG: Leucettinib-21
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Nurse-delivered Care for Adherence/Mood in HIV in South Africa
Status: COMPLETED
Conditions: Immunodeficiency Virus, Human|Depressive Symptoms
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Adherence and Depression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Whey Protein Support to Metabolic and Performance Adaptations in Response HIIT
Status: COMPLETED
Conditions: Muscle, Skeletal|High-Intensity Interval Training|Exercise
Interventions: DIETARY_SUPPLEMENT: Nutrient support to HIIT|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Proteins Fraction Derived From Milk on Osteoporosis Prevention
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DIETARY_SUPPLEMENT: Milk proteins fraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Vinegar on Glucose and Lipid Metabolism in Subjects With Impaired Glucose Tolerance or Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Vinegar|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Evaluating Heterologous-Insert Prime-Boost HIV Vaccine Regimens in HIV-Uninfected Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: rAd35 Env A|BIOLOGICAL: rAd5 Env A|BIOLOGICAL: rAd5 Env B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Effects of Training at Different Intensities in Coronary Artery Patients
Status: COMPLETED
Conditions: Coronary Heart Disease|Quality of Life|Functional Capacity|Fatigue
Interventions: OTHER: Cardio Rehabilitation program|OTHER: Cycling for 20-30 minutes|OTHER: Cycling a total of 4 cycles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Safety Study of Tocilizumab to Improve Transplant Rates in Highly Sensitized Patients Awaiting Kidney Transplantation
Status: COMPLETED
Conditions: End Stage Renal Disease (ESRD)
Interventions: DRUG: Tocilizumab|DRUG: Intravenous Immunoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD19-targeting 3rd Generation CAR T Cells for Refractory B Cell Malignancy - a Phase I/IIa Trial.
Status: COMPLETED
Conditions: B Cell Lymphoma|B Cell Leukemia
Interventions: BIOLOGICAL: Autologous 3rd generation CD19-targeting CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maternal Oxygen Supplementation for Intrauterine Resuscitation
Status: RECRUITING
Conditions: Fetal Distress|Fetal Hypoxia|Labor and Delivery Complication
Interventions: OTHER: Maternal oxygen supplementation|OTHER: Room air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Safety, Tolerability and Preliminary Efficacy Study of DRM01B Topical Gel
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Olumacostat Glasaretil Gel, 7.5%|OTHER: Olumacostat Glasaretil Gel, Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characteristics of Cytokine Response in Patients With Temporomandibular Disorders Treated With Occlusal Splint Therapy
Status: RECRUITING
Conditions: Temporomandibular Joint Disorders
Interventions: DEVICE: Stabilization occlusal splint
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The GLOBAL Vitamin D Study. A Genomic, Transcriptomic, Proteomic and Metabolomic Approach
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DRUG: Cholecalciferol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Obinutuzumab Evaluating Efficacy, Safety and Cost of Disease Management in Participants With Chronic Lymphocytic Leukemia and Comorbidities
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Chlorambucil|DRUG: Obinutuzumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dabrafenib, Trametinib and Hydroxychloroquine in Patients With Advanced BRAF Mutant Melanoma
Status: COMPLETED
Conditions: Advanced BRAF Mutant Melanoma
Interventions: DRUG: Trametinib 2 mg daily|DRUG: hydroxychloroquine (HCQ)|DRUG: dabrafenib 150 mg orally twice a day
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dry Needling to the Multifidus Muscle in Subjects With Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain, Mechanical
Interventions: PROCEDURE: Dry Needling|PROCEDURE: Sham Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ipilimumab for Head and Neck Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Intratumoral Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-severe Systemic Disease Activity
Status: RECRUITING
Conditions: Sjogren's Syndrome
Interventions: DRUG: Dazodalibep|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Central Macular Thickness in Femtosecond Laser-assisted Cataract Surgery
Status: UNKNOWN
Conditions: Age Related Cataracts|Cystoid Macular Edema
Interventions: DEVICE: Femtosecond Laser|OTHER: Manual Cataract Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Dietary Acid Reduction and Progression of Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Cardiovascular Diseases|Hypertension
Interventions: OTHER: Fruits and vegetables (F+V)|DRUG: NaHCO3 Tablets|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ECX + Panitumumab vs. ECX Alone in Locally Advanced Gastric Cancer or Cancer of the Gastroesophageal Junction
Status: COMPLETED
Conditions: Stomach Neoplasms|Gastroesophageal Junction Neoplasms
Interventions: DRUG: Epirubicin, Cisplatin, Capecitabine, Panitumumab|DRUG: Epirubicin, Cisplatin, Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel and Prednisone With or Without Cediranib in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to Hormone Therapy
Status: TERMINATED
Conditions: Adenocarcinoma of the Prostate|Stage IV Prostate Cancer
Interventions: DRUG: cediranib maleate|DRUG: docetaxel|DRUG: prednisone|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasonographic and Surgical Assessment of Endometriosis by AAGL 2021 Endometriosis Classification
Status: UNKNOWN
Conditions: Endometriosis|Bowel Endometriosis|Deep Endometriosis|Ovarian Endometrioma
Interventions: DIAGNOSTIC_TEST: AAGL Endometriosis Classification score - ULTRASOUND|DIAGNOSTIC_TEST: AAGL Endometriosis Classification score - SURGERY
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Rematazolam Besylate, Propofol, and Sevoflurane Perioperative Sedation on Incidence of Emergence Agitation and Hemodynamics in Patients Undergoing Laparoscopic Abdominal Surgery
Status: NOT_YET_RECRUITING
Conditions: Emergence Agitation|Remimazolam Besylate|Perioperative Sedation|Laparoscopic Abdominal Surgery|Anesthesia, General
Interventions: DRUG: Rematazolam Besylate|DRUG: Propofol|DRUG: Sevoflurane|DRUG: Sufentanil|DRUG: Cisatracurium Besylate|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Different Exercise Programs on Knee OA
Status: RECRUITING
Conditions: Osteoarthritis|Knee Osteoarthritis|Arthritis|Joint Diseases|Musculoskeletal Diseases|Rheumatic Diseases
Interventions: OTHER: Exercise for Knee Osteoarthritis -(Land Based Treadmill or Community Walking)|OTHER: Exercise for Knee Osteoarthritis -(LBPP supported low-load treadmill Walking)|OTHER: Exercise for Knee Osteoarthritis - (Aquatic Walking)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons
Status: NOT_YET_RECRUITING
Conditions: Anxiety|Depression|Depression, Anxiety|Anxiety Disorders
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy (ACT)|BEHAVIORAL: Cognitive Behavioral Therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Anti-thymocyte Globulin and Melphalan in Treating Patients With Relapsed Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: anti-thymocyte globulin|DRUG: melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kinesiotaping With and Without Combined Chain Exercises in Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: kinesiotaping with combined chain exercises|OTHER: kinesiotaping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treatment of the Hypertensive Leg Ulcers by PRF Application
Status: TERMINATED
Conditions: Hypertensive Leg Ulcer
Interventions: PROCEDURE: PRF (Platelet-Rich Fibrin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Disposable 7.5Fr Electronic Flexible Ureteroscope Combined 10Fr Ureteral Access Sheath for Treatment of Renal Stone <2cm
Status: COMPLETED
Conditions: Ureteroscopy|Urolithiasis
Interventions: DEVICE: Using disposable 7.5Fr electronic flexible ureteroscope combined 10Fr ureteral access sheath to treat renal stone <2cm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diet Supplementation With Prebiotics to Improve Gut Health in Egyptian Children
Status: RECRUITING
Conditions: Microbial Colonization|Gut Microbiota
Interventions: DIETARY_SUPPLEMENT: Biscuits maltodextrin|DIETARY_SUPPLEMENT: Biscuits includes prebiotics tartoufa inulin|DIETARY_SUPPLEMENT: Biscuits includes prebiotics chicory inulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Investigate the Safety and the Pharmacokinetic, Pharmacodynamic Characteristics of Two BioChaperone® Glucagon Formulations Compared to Marketed GlucaGen® in Subjects With T1DM
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: BioChaperone® glucagon formulation 1|DRUG: BioChaperone® glucagon formulation 2|DRUG: GlucaGen® HypoKit®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Viusid Administration in Subjects With Chronic Inflammatory Syndrome Under Hemodialysis Treatment
Status: SUSPENDED
Conditions: Chronic Inflammatory Syndrome
Interventions: DIETARY_SUPPLEMENT: Viusid|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ß-SPECIFIC 4 Patients: Study of Pediatric EffiCacy and Safety wIth FIrst-line Use of Canakinumab
Status: COMPLETED
Conditions: Systemic Juvenile Idiopathic Arthritis (SJIA)
Interventions: DRUG: ACZ885 150 mg (Canakinumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of Subcutaneous CDX-0159 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: CDX-0159|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gabapentin and Risk of Pancreatic Cancer and Renal Cancer (GPRD)
Status: COMPLETED
Conditions: Renal Pelvis Cancer|Restless Legs Syndrome|Epilepsy|Neuropathic Pain|Chronic Pancreatitis|Hypertension|Pancreatic Cancer|Diabetes|Renal Cancer|Renal Cell Carcinoma
Interventions: DRUG: Gabapentin prescriptions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Clonazepam on Cannabis Withdrawal and Relapse in Treatment-seeking Patients
Status: COMPLETED
Conditions: Cannabis Use Disorder
Interventions: DRUG: Clonazepam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Double Pigtail Plastic Stents During Endoscopic Transmural Drainage of Pancreatic Fluid Collections.
Status: NOT_YET_RECRUITING
Conditions: Pancreatitis, Acute|Pancreatitis, Acute Necrotizing|Pancreatic Pseudocyst|Pancreatic Necrosis|Pancreatitis, Chronic
Interventions: PROCEDURE: Introduction of double pigtail plastic stents through the LAMS during endoscopic transmural drainage of post-inflammatory pancreatic and peripancreatic fluid collections|PROCEDURE: Endoscopic transmural drainage of post-inflammatory pancreatic and peripancreatic fluid collections with use of LAMS only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Distal Ischemic Stroke Treatment With Adjustable Low-profile Stentriever
Status: RECRUITING
Conditions: Ischemic Stroke|Neovascularization
Interventions: DEVICE: Tigertriever 13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Genetic Predictors of Efficiency and Safety of ICIs in Patients With Different Malignancies (ICIPRESIST-0519)
Status: UNKNOWN
Conditions: Melanoma|Squamous Cell Lung Cancer|Uveal Melanoma|Hodgkin Lymphoma
Interventions: GENETIC: Genetic tests of the available tumor and plasma samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Autologous Platelet Concentrations on Orthodontic Treatment Time
Status: COMPLETED
Conditions: Class II Division 1 Malocclusion
Interventions: OTHER: The platelet-rich plasma (PRP)|OTHER: The injectable platelet-rich fibrin (I-PRF) group|DEVICE: The control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of External Diaphragmatic Pacemaker on the Patients With Chronic Cor Pulmonale
Status: COMPLETED
Conditions: Chronic Cor Pulmonale
Interventions: DEVICE: external diaphragmatic pacemaker group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability Study Of Two Lincomycin Hydrochloride Hard Gelatinous Capsule
Status: COMPLETED
Conditions: Bacterial Infections
Interventions: DRUG: Lincomycin|DRUG: Lincomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Positron Emission Tomography in Transcranial Magnetic Stimulation Intervention for Treatment-resistant Depression
Status: RECRUITING
Conditions: Treatment Resistant Depression|Visual Perceptual Weakness
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clary Sage Essential Oil & Pregnancy
Status: UNKNOWN
Conditions: Quality of Life|Pregnancy Related
Interventions: OTHER: Clary Sage Massage Oil|OTHER: Inert Massage Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hydromorphone for ICU-analgesia in Patients With Non-mechanical Ventilation
Status: UNKNOWN
Conditions: Hydromorphone|Analgesia|ICU
Interventions: DRUG: Hydromorphone|DRUG: Fentanyl|DRUG: Butorphanol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Study the Effect Of Single Infusions Of Amphotericin B Lipid Preparations in Treatment of Patients Of Kala Azar
Status: COMPLETED
Conditions: Leishmaniasis, Visceral
Interventions: DRUG: Amphotericin B Lipid emulsion|DRUG: Liposomal Amphotericin B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Participatory Research for Fine-tuning of a 2.0 System to Optimise Home Management of Oral Cancer Therapies.
Status: UNKNOWN
Conditions: Cancer|Oral Drug Administration
Interventions: DEVICE: TreC-Onco
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Effectiveness of Repetitive Transcranial Magnetic Stimulation in the Treatment of Tinnitus
Status: COMPLETED
Conditions: Tinnitus
Interventions: PROCEDURE: Repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Kidney Injury After Cardiac Surgery
Status: NOT_YET_RECRUITING
Conditions: Heart Diseases|Heart Valve Diseases|Heart Shock|Cardiac Disease|Cardio-Renal Syndrome|Cardio Respiratory Arrest|Cardiopulmonary Disease|Cardiopulmonary Arrest With Successful Resuscitation|Cardio-pulmonary Bypass|Cardiothoracic Surgery|Acute Kidney Injury|Acute Kidney Injury Due to Circulatory Failure|Coronary Artery Bypass Surgery
Interventions: PROCEDURE: Cardiac Surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Functional Roll for Non-alcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: DIETARY_SUPPLEMENT: plant fiber|DIETARY_SUPPLEMENT: maltodextrin bar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization
Status: NOT_YET_RECRUITING
Conditions: Osteo Arthritis Knee|Joint Diseases|Musculoskeletal Diseases|Rheumatic Diseases|Arthritis|Osteoarthritis
Interventions: DEVICE: SakuraBead Resorbable Microspheres|DRUG: Corticosteroid Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial for Vestibular Treatment in Concussion
Status: ACTIVE_NOT_RECRUITING
Conditions: Vestibular Disorder|Mild Traumatic Brain Injury
Interventions: BEHAVIORAL: T-REV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: PRIME Care (PRecision Medicine In MEntal Health Care) 2.0
Status: UNKNOWN
Conditions: Psychiatric or Mood Diseases or Conditions
Interventions: DIAGNOSTIC_TEST: Pharmacogenetic test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types
Status: RECRUITING
Conditions: Clinical Stage III Cutaneous Melanoma AJCC v8|Clinical Stage IV Cutaneous Melanoma AJCC v8|Locally Advanced Lung Carcinoma|Locally Advanced Malignant Solid Neoplasm|Locally Advanced Melanoma|Metastatic Lung Carcinoma|Metastatic Malignant Solid Neoplasm|Metastatic Melanoma|Stage III Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Electronic Health Record Review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Investigational Scan (hpMRI) for Monitoring Treatment Response in Patients With Thyroid Cancer and Other Malignancies of the Head and Neck Undergoing Radiation Therapy and/or Systemic Therapy
Status: RECRUITING
Conditions: Thyroid Gland Carcinoma
Interventions: DRUG: Hyperpolarized Carbon C 13 Pyruvate|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Safety and Tolerability Study of FCN-207 in Healthy Volunteers
Status: COMPLETED
Conditions: Hyperuricemia
Interventions: DRUG: Placebo|DIETARY_SUPPLEMENT: fasted vs. high-fat meal|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intramedullary Nailing Versus External Fixation in Open Tibia Fractures in Tanzania
Status: COMPLETED
Conditions: Tibial Fractures|Open Fracture of Tibia|Trauma
Interventions: PROCEDURE: Intramedullary nailing with standard SIGN nail|PROCEDURE: External Fixation with uniplanar Dispofix external fixator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ivermectin Versus Albendazole for Chronic Strongyloidiasis
Status: COMPLETED
Conditions: Chronic Strongyloidiasis
Interventions: DRUG: Ivermectin|DRUG: ivermectin|DRUG: Albendazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comprehensive Geriatric Assessment (Tests) for Bladder Cancer Participants Undergoing Radical Cystectomy
Status: RECRUITING
Conditions: Bladder Cancer
Interventions: OTHER: Educational Video Modules on Risk Prevention Before and After Cystectomy (Surgery)|OTHER: Geriatric Service/ Discharge Planning|OTHER: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Vascular ARDS Recruitment After Inhaled Nitric Oxide
Status: RECRUITING
Conditions: Acute Respiratory Distress Syndrome|Ventilation Perfusion Mismatch
Interventions: DEVICE: Nitric Oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of KPI-121 in Subjects With Postsurgical Inflammation
Status: COMPLETED
Conditions: Ocular Infections, Irritations and Inflammations
Interventions: DRUG: KPI-121 0.25%|DRUG: KPI-121 1.0%|DRUG: Vehicle of KPI-121 0.25%|DRUG: Vehicle of KPI-121 1.0%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rosiglitazone (Avandia®) Treatment in HIV: Its Effect on Blood Vessels
Status: COMPLETED
Conditions: Atherosclerosis|HIV Infections
Interventions: DRUG: Rosiglitazone maleate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Patch Free Treatment for Young Children With Amblyopia
Status: COMPLETED
Conditions: Amblyopia|Binocular Vision Disorder
Interventions: OTHER: Binocular cartoon treatment at home|OTHER: Patching|OTHER: Binocular cartoon treatment in office
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acorai Machine Learning Generalization (MLG) Study
Status: RECRUITING
Conditions: Heart Failure
Interventions: DEVICE: Acorai Sensor Data Collection (ASDC) system 1.0 - Phase 1|DEVICE: Acorai Sensor Data Collection (ASDC) system 1.0 - Phase 2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Erector Spinae Plane Block With Serratus Anterior Plane Block for Breast Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Breast Cancer
Interventions: PROCEDURE: Erector Spinae Plane Block|PROCEDURE: Serratus Anterior Plane Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Transcranial Magnetic Stimulation for Restricted and Repetitive Behavior in ASD
Status: SUSPENDED
Conditions: Autism Spectrum Disorder|Autism|Asperger Syndrome
Interventions: DEVICE: Transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Molnupiravir in Healthy Participants Inoculated With Experimental Influenza Virus (MK-4482-019)
Status: COMPLETED
Conditions: Influenza Infection
Interventions: DRUG: Molnupiravir|DRUG: Placebo molnupiravir|DRUG: Placebo oseltamivir|DRUG: Oseltamivir|BIOLOGICAL: Influenza A Virus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Randomized Double-blind Study Evaluating the Effects of Botulinum Toxin A Associated With ropivacaïne Versus ropivacaïne Alone in the Treatment of the Myofascial Pelviperineal Pain
Status: COMPLETED
Conditions: Myofascial Pelviperineal Pain
Interventions: DRUG: botulinum toxin A + ropivacaïne|DRUG: Ropivacaïne
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of CD5024 0.3% Cream in Subjects With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: CD5024 0.3% cream|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: ETC-159 In Combination With Pembrolizumab In Advanced MSS/pMMR Ovarian Cancers
Status: NOT_YET_RECRUITING
Conditions: With MSS/pMMR Advanced, Platinum-resistant Ovarian Cancer
Interventions: DRUG: ETC-159|DRUG: Pembrolizumab|DRUG: Denosumab / Zoledronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Factors Affecting Patients With Newly Diagnosed Bladder Cancer
Status: UNKNOWN
Conditions: Bladder Cancer
Interventions: DRUG: selenium|DRUG: vitamin E|PROCEDURE: biopsy|PROCEDURE: chemoprevention|PROCEDURE: cryopreservation|PROCEDURE: cytology specimen collection procedure|PROCEDURE: diagnostic procedure|PROCEDURE: gene expression analysis|PROCEDURE: immunohistochemistry staining method|PROCEDURE: laboratory biomarker analysis|PROCEDURE: medical chart review|PROCEDURE: mutation analysis|PROCEDURE: polymerase chain reaction|PROCEDURE: quality-of-life assessment|PROCEDURE: questionnaire administration|PROCEDURE: study of socioeconomic and demographic variables
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Effects of PDE-5 Inhibition on Postprandial Hyperglycemia in Type 2 Diabetes
Status: TERMINATED
Conditions: Type 2 Diabetes
Interventions: DRUG: Tadalafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Doxorubicin Hydrochloride Liposome Injection Combination With Cyclophosphamide vs Pirarubicin Combination With Cyclophosphamide in Patients With Locally Advanced Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Doxorubicin Hydrochloride Liposome injection and cyclophosphamide|DRUG: pirarubicin and cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Mitomycin C on Corneal Haze and Scarring After Corneal Crosslinking in Keratoconus Patients
Status: TERMINATED
Conditions: Keratoconus
Interventions: DRUG: Application of 0.02% MMC over 60 seconds post corneal crosslinking.|DRUG: Corneal crosslinking without the application of 0.02% MMC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Proof of Concept: "Bottom's Up" Seat to Treat Constipation
Status: COMPLETED
Conditions: Constipation Aggravated|Pelvic Floor; Incompetency
Interventions: DEVICE: "the Bottom's Up"
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intradialytic Exercise on the Physical Function of People Undergoing Hemodialysis
Status: COMPLETED
Conditions: End Stage Renal Failure on Dialysis|Frail Elderly Syndrome
Interventions: OTHER: Exercise Plan using resistance bands|DIAGNOSTIC_TEST: Modified Fried Frailty Scale
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ranibizumab Treatment for Age-Related Macular Degeneretion
Status: UNKNOWN
Conditions: Visual Disorder Due to Age-related Macula Degeneration
Interventions: DRUG: Intravitreal Lucentis 0.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluorescence Endoscopy of Esophageal Carcinoma
Status: TERMINATED
Conditions: Esophageal Cancer
Interventions: DRUG: Bevacizumab-IRDye800CW|DEVICE: Molecular Fluorescence Endoscopy platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Adaptive Preventive Intervention for College Alcohol Use
Status: COMPLETED
Conditions: College Student Drinking
Interventions: BEHAVIORAL: Personalized Normative Feedback (PNF)|BEHAVIORAL: Self-Monitoring (SM)|BEHAVIORAL: Web-BASICS|BEHAVIORAL: Health Promotion Consultation|BEHAVIORAL: M-Bridge Online Health Coach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION