pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Impact of Postoperative Adjuvant Chemotherapy in Patients With Hepatocellular Carcinoma After Liver Transplantation
Status: UNKNOWN
Conditions: Liver Transplantation|Hepatocellular Carcinoma|Tumor Recurrence and Metastasis|Survival|Adjuvant Chemotherapy
Interventions: DRUG: gemcitabine and oxaliplatin|DRUG: doxorubicin, 5-Fu and cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Accuracy of Core Stethoscope Auscultation vs. Point of Care Ultrasound in Placement of Endotracheal Tube
Status: NOT_YET_RECRUITING
Conditions: Intubation Complication
Interventions: DEVICE: Eko CORE Stethoscope|DEVICE: Point of care ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact Of Subclinical Hypothyroidism On Short-Term Outcomes In Patients With Acute Coronary Syndrome In Sohag University Hospitals
Status: RECRUITING
Conditions: Subclinical hypothyroïdism|Acute Coronary Syndrome
Interventions: DIAGNOSTIC_TEST: thyroid function tests|DIAGNOSTIC_TEST: cardiac enzymes|DIAGNOSTIC_TEST: ECG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Collagenase on Healing and Scarring
Status: COMPLETED
Conditions: Scarring|Impaired Wound Healing
Interventions: DRUG: Collagenase Santyl|DRUG: Collagenase Santyl Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: HPV-16/18 E6/E7-Specific T Lymphocytes, Relapsed HPV-Associated Cancers, HESTIA
Status: ACTIVE_NOT_RECRUITING
Conditions: Human Papillomavirus-Related Carcinoma|Human Papillomavirus Positive Oropharyngeal Carcinoma|Human Papillomavirus Positive Cervical Carcinoma|Human Papillomavirus Positive Anal Carcinoma|Human Papillomavirus Positive Vulvar Carcinoma|Human Papillomavirus Positive Penile Carcinoma
Interventions: GENETIC: HPV Specific T Cells|DRUG: Cytoxan|DRUG: Fludarabine|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Two Doses of AGTC-501 in Male Participants With X-linked Retinitis Pigmentosa Caused by RPGR Mutations (DAWN)
Status: ENROLLING_BY_INVITATION
Conditions: X-Linked Retinitis Pigmentosa
Interventions: BIOLOGICAL: AGTC-501 (high dose and standard corticosteroid regimen)|BIOLOGICAL: AGTC-501 (low dose and standard corticosteroid regimen)|BIOLOGICAL: AGTC-501 (high dose and modified corticosteroid regimen)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Reversal of HIV Latency With Combination Therapy
Status: NOT_YET_RECRUITING
Conditions: Hiv
Interventions: DRUG: Panobinostat 20 MG Oral Capsule|DRUG: Pyrimethamine 200mg Oral Tablet|DRUG: Lenalidomide 25 MG Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of 5-azacytidine Maintenance After Transplant for AML or MDS
Status: WITHDRAWN
Conditions: Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome (MDS)
Interventions: DRUG: 5-azacytidine (5-aza) maintenance therapy after transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Concomitant Radiotherapy and Zoledronic Acid for Bone Metastases Palliation
Status: COMPLETED
Conditions: Bone Metastases|Breast Cancer|Lung Cancer|Prostate Cancer
Interventions: DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study of Derazantinib (ARQ 087) in Adult Subjects With Advanced Solid Tumors With FGFR Genetic Alterations
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: Derazantinib low dose range|DRUG: Derazantinib middle dose range|DRUG: Derazantinib high dose range|DRUG: Derazantinib at recommended phase 2 dose (RP2D)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-CD19 CAR in PiggyBac Transposon-Engineered T Cells for Relapsed/Refractory B-cell Lymphoma or B-cell Acute Lymphoblastic Leukemia
Status: UNKNOWN
Conditions: B Cell Lymphoma|B-cell Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: Anti-CD19 CAR-T Cells Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A RCT to Assess the Performance of CytoSorb for Shock Reversal in Patients With Vasoplegic Septic Shock
Status: RECRUITING
Conditions: Septic Shock
Interventions: DEVICE: Cytosorb® 300 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab and Tremelimumab and Best Supportive Care vs Best Supportive Care in Patients With Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Tremelimumab|DRUG: Durvalumab|OTHER: Best Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of High Blood Pressure Using Olmesartan With Hydrochlorothiazide Compared to an ACE Inhibitor With a Calcium Channel Blocker
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Olmesartan medoxomil|DRUG: Hydroclorothiazide|DRUG: Benazepril|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Reducing the Rate and Duration of Re-ADMISsions Among Patients With Unipolar Disorder and Bipolar Disorder Using Smartphone-based Monitoring and Treatment - The RADMIS Trials
Status: COMPLETED
Conditions: Affective Disorders|Unipolar Depression|Bipolar Disorder
Interventions: DEVICE: A smartphone-based monitoring system including a) an integrated feedback loop between patients and clinicians and b) context-aware CBT modules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Tea Catechin Consumption on the Prophylaxis of Influenza Infection
Status: COMPLETED
Conditions: Influenza Infection
Interventions: DIETARY_SUPPLEMENT: tea catechin extracts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose Reduction of Lopinavir in Children
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Lopinavir/ritonavir standard dose According to WHO simplified dosing table|DRUG: Lopinavir/ritonavir low dose ( 70% of WHO recommended dosing table)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesia in Patients Undergoing Elective Lumbar Fusion Operations Under General Anesthesia
Status: RECRUITING
Conditions: Post Operative Pain
Interventions: PROCEDURE: Ultrasound Guided Erector Spinae Plane Block|DRUG: Intrathecal morphine|OTHER: General anesthesia using intravenous fentanyl (1µg/kg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Safety and Effectiveness of Giving L-743,872 to Patients With Thrush That Has Not Been Cured With Fluconazole
Status: TERMINATED
Conditions: Candidiasis, Oral|HIV Infections
Interventions: DRUG: L-743,872
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Eylea for Central Retinal Vein Occlusion (CRVO)
Status: COMPLETED
Conditions: Retinal Vein Occlusion
Interventions: DRUG: Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Automatic Positive Airway Pressure on Treatment Compliance in OSA Patients Awaiting Bariatric Surgery
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Treatment Compliance|Automatic Positive Airway Pressure
Interventions: DEVICE: Positive airway pressure for the treatment of OSA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Meditoxin® Treatment in Patients With Cervical Dystonia
Status: COMPLETED
Conditions: Dystonia|Dystonic Disorder
Interventions: DRUG: Meditoxin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Study of Outpatient Automated Blood Glucose Control With a Bihormonal Bionic Pancreas
Status: COMPLETED
Conditions: Diabetes Mellitus Type 1
Interventions: DEVICE: Bionic Pancreas|DEVICE: Insulin pump with or without CGM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monoclonal Antibody Therapy Plus Cyclosporine and Peripheral Stem Cell Transplantation in Treating Patients With Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: cyclosporine|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: indium In 111 monoclonal antibody m170|RADIATION: yttrium Y 90 monoclonal antibody m170
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Integrating MOUD in African American Community Settings (Better Together)
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder
Interventions: BEHAVIORAL: HC-MOUD Only|BEHAVIORAL: BT-MOUD with Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Cemiplimab Alone or in Combination With Fianlimab and/or Other Experimental Agents in Adult Participants With Peri-operative Stage III/IV Cutaneous Squamous Cell Carcinoma (CSCC)
Status: WITHDRAWN
Conditions: Cutaneous Squamous Cell Carcinoma
Interventions: DRUG: cemiplimab|DRUG: fianlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Adverse Events and How Intravenous (IV) ABBV-47D11 and IV ABBV-2B04 Given Alone and in Combination Moves Through the Body of Adult Participants With Coronavirus Disease 2019 (COVID-19)
Status: COMPLETED
Conditions: CoronaVirus Disease-2019 (COVID-19)
Interventions: DRUG: ABBV-47D11|DRUG: Placebo for ABBV-47D11|DRUG: ABBV-2B04|DRUG: Placebo for ABBV-2B04
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Examining Long-Term Effects and Neural Mediators of Behavioral Treatments for Social Anxiety Disorder
Status: COMPLETED
Conditions: Social Anxiety Disorder
Interventions: BEHAVIORAL: Acceptance- and commitment-based behavioral therapy|BEHAVIORAL: Cognitive behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation of Dexamethasone to Increase Duration of Transversus Abdominal Plane Block Following Cesarean Section
Status: TERMINATED
Conditions: Post Surgical Pain
Interventions: DRUG: 2mg Dexamethasone|DRUG: 4mg Dexamethasone|DRUG: Ropivacaine (TAP blocks)|DRUG: Morphine|DRUG: Bupivacaine Hydrochloride|DRUG: Normal saline 1ml|DRUG: Normal saline 0.5ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus
Status: WITHDRAWN
Conditions: Endothelial Dysfunction|Bone Disease
Interventions: OTHER: Isosorbide-5-mononitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of AB-106 in Chinese Healthy Adult Men Evaluated the Effects of Itraconazole and Rifampicin on AB-106 PK
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: AB-106, Itraconazole|DRUG: AB-106, Rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of VN-0200 in Japanese Healthy Adults and Elderly Subjects
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: VN-0200|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: DON in Pediatric Cerebral Malaria
Status: RECRUITING
Conditions: Malaria, Cerebral
Interventions: DRUG: 6-diazo-5-oxo-L-norleucine (DON)|DRUG: Placebo|DRUG: 6-diazo-5-oxo-L-norleucine (DON)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COV-CHIM02: SARS-CoV-2 Omicron BA.5 Subvariant Dose Finding Infection Study
Status: RECRUITING
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: Omicron BA.5 SARS-CoV-2 challenge virus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Long-Term Development of Muscular Dystrophy Outcome Assessments
Status: RECRUITING
Conditions: LGMD1B|LGMD1C|LGMD1D|LGMD1E|LGMD1F|LGMD1G|LGMD1H|LGMD2A|LGMD2B|LGMD2C|LGMD2D|LGMD2E|LGMD2F|LGMD2G|LGMD2I|LGMD2J|LGMD2K|LGMD2L|LGMD2M|LGMD2N|LGMD2O|LGMD2P|LGMD2Q|LGMD2S|LGMD2T|LGMD2U|LGMD2W|LGMD2X|LGMD2Y
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Gemcitabine and Oxaliplatin (Gem-Ox) Plus Glivec in Gemcitabine-refractory Pancreatic Cancer
Status: COMPLETED
Conditions: Advanced Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kinectics of Donor-specific Anti-HLA Antibody After HLA-incompatible Allogeneic Haematopoietic Stem Cell Transplantation
Status: RECRUITING
Conditions: Haematological Malignancy
Interventions: OTHER: Detection of donor-specific anti-HLA antibody (DSA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunological and Viral Parameters in Patients Receiving Anti-epileptic Drugs
Status: COMPLETED
Conditions: Epilepsy|Drug Hypersensitivity Syndrome
Interventions: DRUG: anti-epileptic drug|BIOLOGICAL: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Trial for Patients With Advanced/Recurrent Endometrial Cancer
Status: COMPLETED
Conditions: Neoplasms|Neoplasms by Site|Urogenital Neoplasms|Genital Neoplasms, Female|Uterine Neoplasms|Endometrial Neoplasms|Cancer of Endometrium|Endometrial Cancer|Cancer of the Endometrium|Endometrium Cancer|Neoplasms, Endometrial
Interventions: DRUG: pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting CSD500 Use Among Women in Established Relationships
Status: COMPLETED
Conditions: PSA|Unprotected Sex
Interventions: DEVICE: CSD500 Condom|DEVICE: Standard Condom|BEHAVIORAL: Condom Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Translation, Cultural Adaptation, Reliability, and Validity of the Turkish Version of the Cervical Radiculopathy Impact Scale
Status: UNKNOWN
Conditions: Cervical Radiculopathy|Cervical Radicular Pain|Cervical Radiculitis|Cervical Root Syndrome
Interventions: OTHER: Survey study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety/Efficacy of Zoledronic Acid and Alendronate on Bone Metabolism in Postmenopausal Women With Osteoporosis
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Zoledronic acid 5 mg solution|DRUG: Alendronate 70 mg tablets|DRUG: Calcium/Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of SHR0410 Injection for the Treatment of Pain After Laparoscopic Surgery
Status: UNKNOWN
Conditions: Postoperative Pain Of Laparoscopic Surgery
Interventions: DRUG: SHR0410 Injection|DRUG: SHR0410 Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Compare the Outcome of Temporary Portocaval Shunt During Recipient Hepatectomy Versus No Shunt in Adult Elective Live Donor Liver Transplantation.
Status: UNKNOWN
Conditions: Portosystemic Shunt
Interventions: PROCEDURE: Temporary Portocaval Shunt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Birth Ball and Birth Dance Applied in the First Stage of Labor on Some Parameters
Status: NOT_YET_RECRUITING
Conditions: Pain, Labor|Satisfaction, Patient
Interventions: BEHAVIORAL: Experimental (birth ball)|BEHAVIORAL: Experimental (birth dance)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Paclitaxel and Radiation Therapy With or Without Trastuzumab in Treating Patients Who Have Undergone Surgery for Bladder Cancer
Status: COMPLETED
Conditions: Bladder Urothelial Carcinoma|Stage I Bladder Cancer AJCC v6 and v7|Stage II Bladder Cancer AJCC v6 and v7|Stage III Bladder Cancer AJCC v6 and v7
Interventions: DRUG: Paclitaxel|RADIATION: Radiation Therapy|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endovascular Revascularization of Symptomatic Chronically Occluded Internal Carotid Artery
Status: WITHDRAWN
Conditions: Stroke|Occlusion Carotid
Interventions: PROCEDURE: angioplasty and stenting of occluded cervical ICA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Bepirovirsen in Nucleos(t)Ide Analogue-treated Participants With Chronic Hepatitis B (B-Well 2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Hepatitis B|Hepatitis B, Chronic
Interventions: DRUG: Bepirovirsen|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rosmalip® for Cancer Infections Prevention
Status: COMPLETED
Conditions: Infections|Covid19|Cancer
Interventions: DIETARY_SUPPLEMENT: Rosmalip®|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Blood Sugar Take Care and Glucose Metabolism
Status: WITHDRAWN
Conditions: Prediabetes
Interventions: DIETARY_SUPPLEMENT: Blood Sugar Take Care|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assess the Safety, Efficacy, and Pharmacokinetics of Immediate and Delayed Release Weekly Risedronate
Status: COMPLETED
Conditions: Postmenopausal Women
Interventions: DRUG: risedronate|DRUG: risedronate|DRUG: risedronate|DRUG: risedronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Temsirolimus and Cetuximab in Patients With Advanced or Metastatic Solid Tumors
Status: UNKNOWN
Conditions: Patients With Advanced or Metastatic Solid Tumors
Interventions: DRUG: Cetuximab|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Prevention Pathways Toward Tribal Colorectal Health
Status: COMPLETED
Conditions: Colorectal Neoplasm
Interventions: BEHAVIORAL: High Intensity (Group 1)|BEHAVIORAL: Medium Intensity (Group 2)|BEHAVIORAL: Reference Group (Group 3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Use of Serial Plasma NGS as a New Efficacy Metric to Guide Immunotherapy Treatment Discontinuation
Status: RECRUITING
Conditions: Melanoma|Non-small Cell Lung Cancer
Interventions: OTHER: Evaluation of ctDNA using the F1T after 1 year of immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Intracoronary Prourokinase on the Coronary Flow During Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction|Percutaneous Coronary Intervention|Thrombolytic Therapy
Interventions: DRUG: Prourokinase|DRUG: Tirofiban|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pelvic Floor Muscle Exercises Applied During Pregnancy on Genito-Pelvic Pain Level in Postpartum Period
Status: COMPLETED
Conditions: Genito-Pelvic Pain|Pelvic Floor Muscle Exercise|Pregnancy
Interventions: BEHAVIORAL: Pelvic floor muscle exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Methylphenidate for Apathy in Alzheimer's Dementia: A Controlled Study
Status: COMPLETED
Conditions: Alzheimer's Disease|Apathy|Dementia
Interventions: DRUG: Methylphenidate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Pharmacokinetics of BGB-3111 in Subjects With B-Cell Lymphoid Malignancies
Status: COMPLETED
Conditions: B-cell Malignancies
Interventions: DRUG: Zanubrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Antibiotic Treatment in Hemodialysis
Status: RECRUITING
Conditions: Hemodialysis
Interventions: DRUG: Amoxicillin Clavulanic 500/125mg or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Blueberry Dry Powder on Glycemic Status in Subjects With Prediabetes
Status: COMPLETED
Conditions: Prediabetes
Interventions: DIETARY_SUPPLEMENT: Low dose of blueberry dry powder|DIETARY_SUPPLEMENT: High dose of blueberry dry powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Tolerability of Combination Antihypertensive Drug in Non-Responders to ARB monoTHerapy Using 24h ABPM
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: SEVIKAR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of a Fixed-dose Combination of Naratriptan and Naproxen in Acute Treatment of Migraine.
Status: WITHDRAWN
Conditions: Migraine|Headache
Interventions: DRUG: naratriptan + naproxen|DRUG: naratriptan|DRUG: naproxen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Alimta® (Pemetrexed) Plus VELCADE® (Bortezomib) or Alimta Alone or VELCADE Alone in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Failed Prior Therapy
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: VELCADE|DRUG: Alimta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Soy Derivatives for Control of Hot Flashes in Men on Androgen Deprivation Therapy
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: Flav-ein capsules|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Probiotic in Treatment of Persistent Diarrhea in Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Diarrhea
Interventions: COMBINATION_PRODUCT: LiveSpo DIA30|COMBINATION_PRODUCT: LiveSpo CLAUSY|OTHER: RO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Video-call Assisted Assessment of Acute Stroke in Addition to Stroke Severity Scales in a Prehospital Setting
Status: COMPLETED
Conditions: Cerebrovascular Disorders|Brain Diseases|Central Nervous System Diseases|Stroke|Nervous System Diseases|Vascular Diseases
Interventions: DIAGNOSTIC_TEST: Video call
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Focused Ultrasound Ablation and PD-1 Antibody Blockade in Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma|Breast Cancer|Merkel Cell Carcinoma|Squamous Cell Cancer|Non Small Cell Lung Cancer|Cervical Cancer|Urothelial Carcinoma|Ovarian Cancer|Hepatocellular Carcinoma|Small-cell Lung Cancer|Microsatellite Instability High|Gastric Cancer|Esophageal Cancer
Interventions: DEVICE: Echopulse|DRUG: Poly ICLC|DRUG: Standard of Care PD-1 Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Ketorolac in Surgical Neonates
Status: COMPLETED
Conditions: Postoperative Pain Control in Surgical Neonates
Interventions: DRUG: Ketorolac|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mod of Cognitive Flexibility by tDCS, Tyrosine Polymorphisms in the COMT Gene
Status: UNKNOWN
Conditions: Modulation of Cognitive Flexibility by Transcranial Direct Current Stimulation, Tyrosine Administration and Polymorphisms in the COMT Gene
Interventions: COMBINATION_PRODUCT: tdcs (sham/anodal) + drug (placebo/tyrosine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Ultra_HYPofractionated RadiotHerapy in Women With BrEast CaNcer Receiving Regional Nodal Radiation vs Nodal Moderate Hypofractionated Radiotherapy
Status: RECRUITING
Conditions: Malignant Breast Neoplasm
Interventions: RADIATION: Ultra-hypofractionated whole breast radiotherapy|RADIATION: Standard Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Simvastatin Versus Simvastatin/Ezetimibe on Small Dense Low -Density Lipoprotein (LDL)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: SIMVASTATIN 40 mg|DRUG: SIMVASTATIN/EZETIMIBE 10/10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expanded Access Protocol of Patisiran for Patients With Hereditary ATTR Amyloidosis (hATTR)
Status: APPROVED_FOR_MARKETING
Conditions: TTR-mediated Amyloidosis|Amyloidosis, Hereditary|Amyloid Neuropathies, Familial|Familial Amyloid Polyneuropathies|Amyloid Neuropathies|Amyloidosis, Hereditary, Transthyretin-Related
Interventions: DRUG: patisiran (ALN-TTR02)
Study Type: EXPANDED_ACCESS
Clinical trial: Studies of the Safety and Immunogenicity of a Sabin Inactivated Poliovirus Vaccine
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: Single-dose regimen of high dosage investigational sIPV|BIOLOGICAL: Single-dose regimen of medium dosage investigational sIPV|BIOLOGICAL: Three-dose regimen of high dosage investigational sIPV|BIOLOGICAL: Three-dose regimen of medium dosage investigational sIPV|BIOLOGICAL: Three-dose regimen of low dosage investigational sIPV|BIOLOGICAL: Three-dose regimen of commercialized sIPV|BIOLOGICAL: Three-dose regimen of commercialized IPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Prospective Study to Evaluate the Safety of a New Trivalent Intranasal Influenza Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Trivalent influenza virus vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficiency of a Nurse-led Self-management Education Intervention in Promoting Safety Knowledge and Skills of Patients With Arthritis Treated Par Biologics
Status: COMPLETED
Conditions: Rheumatoid Arthritis (RA)|Spondyloarthritis (SpA)
Interventions: OTHER: Nurse-led self-management education intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Lateral Pharyngoplasty on Blood Pressure in Obstructive Sleep Apnea (OSA) Patients
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea|High Blood Pressure
Interventions: PROCEDURE: Lateral Pharyngoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cells for Prevention of Bronchopulmonary Dysplasia in Infants
Status: RECRUITING
Conditions: Bronchopulmonary Dysplasia
Interventions: BIOLOGICAL: Human Umbilical Cord Derived-Mesenchymal Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Anti-reflux Mucosal Valvuloplasty Versus PPIs for GERD Treatment
Status: NOT_YET_RECRUITING
Conditions: Gastroesophageal Reflux Disease
Interventions: PROCEDURE: anti-reflux mucosal valvuloplasty (ARMV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Subcutaneously Administered ENT-03 for the Treatment of Obesity and Diabetes
Status: RECRUITING
Conditions: Obesity|Diabetes Mellitus, Type 2
Interventions: DRUG: ENT-03|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Examining the Effects of (MiM) Treatment on Emotional and Cognitive Functioning of Residents in Long-term Care
Status: COMPLETED
Conditions: Emotion|Impaired Cognition
Interventions: BEHAVIORAL: Music, Imagery, Movement|BEHAVIORAL: Social Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diode Laser for Treatment of Peri-implantitis
Status: COMPLETED
Conditions: Peri-Implantitis|Implant Complication
Interventions: DEVICE: Laser treatment|PROCEDURE: Surgical treatment with adjunctive systemic antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Orforglipron in Adult Participants With Obesity or Overweight and Type 2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Overweight|Type 2 Diabetes
Interventions: DRUG: Orforglipron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetic Study of Tenofovir Alafenamide (TAF)/Elvitegravir (EVG) Administered Rectally
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: TAF/EVG Insert
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Subcutaneous Risankizumab Injection to Assess Change in Palmoplantar Pustulosis Area and Severity Index [PPPASI] in Adult Japanese Participants With Palmoplantar Pustulosis
Status: COMPLETED
Conditions: Palmoplantar Pustulosis (PPP)
Interventions: DRUG: Risankizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of AMG 714 in Adult Patients With Type II Refractory Celiac Disease
Status: COMPLETED
Conditions: Type II Refractory Celiac Disease (RCD-II)|In-situ Small Bowel T-cell Lymphoma
Interventions: BIOLOGICAL: AMG 714|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Distant Management of Crohn's Disease by Smartphones is Feasible and Effective Additionally it Reduces the Costs
Status: COMPLETED
Conditions: Crohn Disease
Interventions: OTHER: real time online video visit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study Of Rosiglitazone XR In Subjects With Mild-to-Moderate Alzheimers
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: Rosiglitazone XR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metoclopramide and the Length of First Stage of Labor , a Randomized Controlled Trial
Status: COMPLETED
Conditions: Labour Duration and Metoclopramide
Interventions: DRUG: Metoclopramide 10mg|DRUG: Placebo (0.9 sodium chloride)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Comparison of Pelvic Lymphadenectomy Versus Isolated Sentinel Lymph Node Biopsy Procedure for Early Stages of Cervical Cancers : a Multicenter Study With Evaluation of Medico-economic Impacts
Status: COMPLETED
Conditions: Uterine Cervical Dysplasia
Interventions: PROCEDURE: identification of sentinel nodes + full pelvic lymph-node dissection|PROCEDURE: only identification of sentinel nodes (without pelvic lymph-node dissection)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Study of Santyl Ointment to Treat Pressure Ulcers
Status: TERMINATED
Conditions: Pressure Ulcer|Soft Tissue Necrosis Lower Limb
Interventions: DEVICE: Negative Pressure Wound Therapy|BIOLOGICAL: Collagenase Ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cost-utility Study of Continuous Positive Airway Pressure Treatment in Obstructive Sleep Apnea Syndrome Patients
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea Syndrome
Interventions: DEVICE: CPAP S8- Scape / Resmed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Lidocaine for Treating Intrathecal Fentanyl Induced Pruritus
Status: NOT_YET_RECRUITING
Conditions: Pruritus Caused by Drug
Interventions: DRUG: Lidocaine IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Single Photon Emission Computed Tomography (SPECT) Lymph Node Mapping
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate
Interventions: OTHER: Single Photon Emission Computed Tomography (SPECT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Perioperative Panitumumab and Epirubicin, Oxaliplatin and Xeloda (EOX) in Patients With Gastroesophageal Adenocarcinoma
Status: TERMINATED
Conditions: Esophageal Adenocarcinoma|Gastric Adenocarcinoma
Interventions: DRUG: panitumumab, epirubicin, oxaliplatin, xeloda
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regional Blocks for CABG Artery Bypass Graft Surgery
Status: NOT_YET_RECRUITING
Conditions: Analgesia After Coronary Artery Bypass Graft Surgery
Interventions: PROCEDURE: Pectointercostal plane block and external oblique intercostal plane block|PROCEDURE: Fentanyl infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Wet AMD Recurrence Rate in Patients Stable on Three Month Ranibizumab Dosing
Status: COMPLETED
Conditions: Age Related Macular Degeneration
Interventions: DRUG: Ranibizumab|DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Drug-Drug Interaction (DDI) Between HSK16149 Capsules and Metformin Hydrochloride Tablets
Status: UNKNOWN
Conditions: Diabetic Neuropathies|Diabetic Neuropathy Peripheral
Interventions: DRUG: HSK16149|DRUG: Metformin Hydrochloride tablet|DRUG: HSK16149+Metformin（phase 3）
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About the Study Medicine Sisunatovir in Adults With Respiratory Syncytial Virus (RSV) Infection
Status: RECRUITING
Conditions: Respiratory Syncytial Virus Infection
Interventions: DRUG: Sisunatovir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Eslicarbazepine Acetate as Adjunctive Therapy for Partial Seizures in Elderly Patients
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Eslicarbazepine Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trifluridine/Tipiracil (TAS-102) With or Without Thalidomide for the Treatment of Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Thalidomide|DRUG: TAS-102
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concentration Controlled Everolimus With Reduced Dose Cyclosporine Versus Mycophenolate Mofetil With Standard Dose Cyclosporine in de Novo Renal Transplant Adult Recipients Treated With Basiliximab and Corticosteroids
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: Everolimus|DRUG: Mycophenolate mofetil (MMF)|DRUG: Basiliximab|DRUG: Cyclosporine A|DRUG: Corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: WHAT (Women, Hot-flashes, Activity, Trial) - Physical Activity for Treatment of Hot Flushes Among Postmenopausal Women
Status: COMPLETED
Conditions: Postmenopausal Symptoms|Hot Flashes
Interventions: BEHAVIORAL: Physical activity intervention program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dapagliflozin in Non Alcoholic Fatty Liver Disease Associated Cirrhosis and Its Role in Preventing Development of Chronic Kidney Disease.
Status: NOT_YET_RECRUITING
Conditions: NAFLD Cirrhosis
Interventions: DRUG: Dapagliflozin|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FlaxFx, A Research Study of the Effects of Flaxseed Lignans on Colon Health
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Flaxseed Lignans
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of AggreGuide A-100 (ADP) Assay
Status: COMPLETED
Conditions: Risk Factor, Cardiovascular|Platelet Dysfunction Due to Drugs
Interventions: DRUG: P2Y12 inhibitor|DEVICE: Platelet function test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Preputial Graft Versus Preputial Flap in Treatment of Proximal Hypospadias With Marked Ventral Curvature (a Comparative Study)
Status: RECRUITING
Conditions: Hypospadias, Penoscrotal
Interventions: PROCEDURE: Bracka's repair using preputial graft|PROCEDURE: STPIF (Staged Transverse Preputial Island Flap) repair using preputial flap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BI-1206 and an Anti-CD20 Antibody in Patients With CD32b Positive B-cell Lymphoma or Leukaemia
Status: COMPLETED
Conditions: B-cell Lymphoma|Chronic Lymphocytic Leukaemia|Waldenström Macroglobulinemia
Interventions: BIOLOGICAL: BI-1206 single agent dose escalation phase|BIOLOGICAL: Combination of BI-1206 with rituximab escalation phase|BIOLOGICAL: BI-1206 single agent expansion phase|BIOLOGICAL: Combination of BI-1206 with rituximab expansion phase
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Stem Cell Transplantation for Myelofibrosis and Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Myelofibrosis
Interventions: DRUG: Busulfan|DRUG: Fludarabine|DRUG: Thymoglobulin (ATG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Oral VT-464 in Patients With Castration-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Castration-resistant Prostate Cancer|CRPC
Interventions: DRUG: Seviteronel: given orally once daily in 28 day cycles
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy
Status: NOT_YET_RECRUITING
Conditions: Arrhythmogenic Cardiomyopathy|Arrhythmogenic Right Ventricular Cardiomyopathy
Interventions: DRUG: Tideglusib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Dose Bupivacaine Versus Prilocaine Regarding Hemodynamic Stability and Safety in Geriatrics
Status: RECRUITING
Conditions: Recruitment
Interventions: DRUG: Bupivacain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Speaking Valve Combined With Airway Pressure Predicts Upper Airway Patency in Adult Tracheotomized Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Tracheotomy
Interventions: DIAGNOSTIC_TEST: speaking valve combined with airway pressure|DIAGNOSTIC_TEST: Bronchoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effectiveness of a Customized Mobile Application in Colonoscopy Preparation
Status: COMPLETED
Conditions: Colonoscopy Preparation
Interventions: OTHER: Instruction leaflet|OTHER: Mobile App|OTHER: Explanation of paper and application instructions|OTHER: Picoprep solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Absorption, Metabolism and Excretion of Dietary Polyphenolic Bioactives in Humans
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Thearubigins|OTHER: Theaflavins|OTHER: Procyanidin Dimer B2 (DB2)|OTHER: (-)-Epigallocatechin-3-O-gallate (EGCG)|OTHER: (-)-Epicatechin-3-O-gallate (ECG)|OTHER: (-)-Epicatechin (EC)|OTHER: (-)-Epigallocatechin (EGC)|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase I Study of the Safety and Immunogenicity of rgp120/HIV-1IIIB Vaccine in Healthy Adult Subjects (NOTE: Study Extended ONLY for Subjects Who Have Previously Received rgp120/HIV-1IIIB or rgp120/HIV-1MN on VEU 006 or VEU 006 Rollover Study)
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: rgp120/HIV-1IIIB|BIOLOGICAL: rgp120/HIV-1MN
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION