pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety of Elobixibat in Combination With Cholestyramine for Nonalcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Nonalcoholic Fatty Liver|Nonalcoholic Steatohepatitis
Interventions: DRUG: Elobixibat 10mg + cholestyramine powder 9g (cholestyramine 4g)|DRUG: Elobixibat 10mg + cholestyramine powder placebo|DRUG: Elobixibat placebo + cholestyramine powder 9g (cholestyramine 4g)|DRUG: Elobixibat placebo + cholestyramine powder placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of G3139 in Subjects With Advanced Melanoma, Including Those With Normal Hepatic Function and Those With Moderate Hepatic Impairment
Status: TERMINATED
Conditions: Advanced Melanoma and Normal or Impaired|Hepatic Function
Interventions: DRUG: Genasense® (G3139, oblimersen sodium)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ASPIRIN Trial Belgium
Status: ACTIVE_NOT_RECRUITING
Conditions: Colon Cancer
Interventions: DRUG: acetylsalicylic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment of Premature Ejaculation
Status: COMPLETED
Conditions: Premature Ejaculation
Interventions: DRUG: Intervention A|DRUG: Intervention B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Saxenda® in Obese or Overweight Patients With Stable Bipolar Disorder (Investigator Initiated)
Status: COMPLETED
Conditions: Bipolar Disorder|Obesity
Interventions: DRUG: LIRAGLUTIDE|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Comparison of Transcervical Foley Bulb With Vaginal Misoprostol to Vaginal Misoprostol Alone for Induction of Labor
Status: COMPLETED
Conditions: Pregnancy
Interventions: DEVICE: misoprostol|DEVICE: Foley bulb
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Giving Information Systematically and Transparently in Lung and GI Cancer Phase 2
Status: COMPLETED
Conditions: Critical Illness|Oncology|Communication
Interventions: BEHAVIORAL: Oncolo-GIST|BEHAVIORAL: Usual Care Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PG2 Treatment Among Stage II/III Breast Cancer Patients Receiving Adjuvant Chemotherapy
Status: COMPLETED
Conditions: Cancer-related Fatigue|Neutropenia, Malignant
Interventions: DRUG: Astragalus polysaccharides 500 mg|DRUG: Placebo|PROCEDURE: EC Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy And Safety Of Parecoxib 40mg vs. Ketoprofen 100mg In The Management Of Acute Renal Colic
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Ketoprofen 100mg|DRUG: Parecoxib 40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Microbiological Evaluation of the Efficacy of Water to Clean Tracheostomy Inner Cannulas
Status: UNKNOWN
Conditions: Tracheostomy Complication
Interventions: OTHER: Detergent|OTHER: Sterile water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 3, Pivotal Trial of VB-111 Plus Bevacizumab vs. Bevacizumab in Patients With Recurrent Glioblastoma (GLOBE)
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: VB-111 + bevacizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Investigate the Effect of PEMF for Pateitns After Anterior Cruciate Ligament Reconstruction With Hamstring Autograft
Status: RECRUITING
Conditions: Anterior Cruciate Ligament Reconstruction|Hamstring Muscle
Interventions: DEVICE: PEMF treatment|DEVICE: Placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuromodulation Device Use in Patients With Major Depressive Disorder
Status: WITHDRAWN
Conditions: Clinical Depression
Interventions: DEVICE: Device|DEVICE: Sham Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Ankle Assist Robot on Gait Function and Cardiopulmonary Metabolic Efficiency in Stroke Patients
Status: COMPLETED
Conditions: Stroke|Gait, Hemiplegic
Interventions: DEVICE: Ankle Assist Robot
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Soft Tissue Width and Abutment Height Influence Peri-implant Bone Resorption
Status: COMPLETED
Conditions: Alveolar Bone Loss
Interventions: PROCEDURE: implant insertion|PROCEDURE: operculectomy|PROCEDURE: prosthetic rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: N-Acetyl Cysteine Effect on Liver Function After Mitral Valve Replacement
Status: RECRUITING
Conditions: Oxidative Stress|Liver Dysfunction
Interventions: DRUG: N acetyl cysteine|OTHER: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Prevention and Treatment of Nausea Associated With Motion Sickness
Status: COMPLETED
Conditions: Motion Sickness
Interventions: DRUG: Scopolamine Nasal Gel|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Helping Overcome Pressure and Exhaustion: Empowerment Classes for Southeast Asian Migrant Care Workers
Status: NOT_YET_RECRUITING
Conditions: Heart Rate Variability|Burnout|Depression
Interventions: BEHAVIORAL: HOPE empowerment classes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dexmedetomidine on Optic Nerve Sheath Diameter
Status: WITHDRAWN
Conditions: Intracranial Hypertension
Interventions: DRUG: Dexmedetomidine|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intramedullary Nailing Versus Plate Fixation of Ankle Fractures. A Prospective, Randomized Controlled Trial.
Status: ACTIVE_NOT_RECRUITING
Conditions: Ankle Fractures
Interventions: DEVICE: Compression screws and neutralization plate|DEVICE: Acumed Fibular Rod System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TRINOVA-3: A Study of AMG 386 or AMG 386 Placebo in Combination With Paclitaxel and Carboplatin to Treat Ovarian Cancer
Status: TERMINATED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Peritoneal Cancer
Interventions: DRUG: AMG 386|DRUG: Paclitaxel|DRUG: AMG 386 Placebo|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bepanthen Versus Cetomacrogol in Epidermal Growth Factor Receptor Inhibitors (EGFRI)
Status: COMPLETED
Conditions: Cancer|Skin Rash
Interventions: OTHER: dexpanthenol 5% cream|OTHER: Cetomacrogol cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Reactogenicity Trial of Vaccine for the Prevention of Infections Caused by Haemophilus Influenzae Type b
Status: COMPLETED
Conditions: Haemophilus Influenzae Infection|Vaccines
Interventions: BIOLOGICAL: Vaccine for the prevention of infections caused by Haemophilus influenza type b|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Inflammatory Aspects of Glucose in Hyperlipidemia and Diabetes
Status: COMPLETED
Conditions: Atherosclerosis|Leukocyte Activation Disorder|Type 2 Diabetes Mellitus|Familial Combined Hyperlipidemia
Interventions: DIETARY_SUPPLEMENT: OGTT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Study to Evaluate the Efficacy and the Safety of Eradication Therapy for Helicobacter Pylori in Functional Dyspepsia
Status: UNKNOWN
Conditions: Functional Dyspepsia|Helicobacter Pylori Infection
Interventions: DRUG: Lansoprzole+Amoxicillin+Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Antibiotic/COPD in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) Requiring Mechanical Ventilation
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Sepsis|Antibiotics
Interventions: DRUG: ciprofloxacin|DRUG: trimethoprim-sulfamethoxazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Rosiglitazone on the Diuretic Effect of Furosemide and Amiloride
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: DRUG: Rosiglitazone versus placebo|DRUG: response (sodium excretion) to amiloride infusion|DRUG: response (sodium excretion) to furosemide infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical/Microbiological Impact of a Specific Antimicrobial Stewardship Program for Nursing Homes
Status: COMPLETED
Conditions: Human Microbiome|Antibiotic Resistant Infection|Nursing Homes
Interventions: BEHAVIORAL: PROA Experimental|OTHER: PROA Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Public Health Nurse-Delivered 1-Day CBT Workshops for PPD
Status: ACTIVE_NOT_RECRUITING
Conditions: Postpartum Depression
Interventions: BEHAVIORAL: 1-Day Cognitive Behavioural Therapy-Based Workshop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes
Status: COMPLETED
Conditions: Coronary Disease|Cardiovascular Diseases|Heart Diseases|Insulin Resistance|Diabetes Mellitus|Diabetes Mellitus, Non-Insulin-Dependent
Interventions: PROCEDURE: Angioplasty, Transluminal, Percutaneous Coronary, other catheter-based interventions|PROCEDURE: Coronary Artery Bypass|DRUG: Biguanides, thiazolidinediones|DRUG: Insulin, sulfonylurea|DRUG: ACE Inhibitors, Angiotensin Receptor Blockers, Beta Blockers, Calcium Channel Blockers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of MDX-1203 in Subjects With Advanced/Recurrent Clear Cell Renal Cell Carcinoma (ccRCC) or Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (B-NHL)
Status: COMPLETED
Conditions: Renal Cell Carcinoma|Non-hodgkin's Lymphoma
Interventions: BIOLOGICAL: MDX-1203
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impacting the Disposal of Unused Opioid
Status: COMPLETED
Conditions: Opioid Use and Disposal
Interventions: OTHER: Pamphlet education|OTHER: Pamphlet education + texts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Pembrolizumab With or Without Platinum-based Combination Chemotherapy Versus Chemotherapy Alone in Urothelial Carcinoma (MK-3475-361/KEYNOTE-361)
Status: COMPLETED
Conditions: Urothelial Carcinoma Associated 1 RNA, Human
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nasopharyngeal Bacterial Carriage and Antibiotic Resistance in Children With Sickle Cell Disease in Ile-De-France
Status: UNKNOWN
Conditions: Sickle Cell Disease
Interventions: PROCEDURE: nasopharyngeal swabbing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Lifestyle-modifying Interventions in Low-risk MDS Patients
Status: NOT_YET_RECRUITING
Conditions: Myelodysplastic Syndromes
Interventions: OTHER: Fasting-mimicking diet (FMD) and physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Explore the Dose of HCP1803 in Patients With Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: HCP1803-3|DRUG: RLD2003|DRUG: RLD2004|DRUG: RLD2005|DRUG: HPP2003-3|DRUG: HPP2005
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Motivational Negative Symptoms in Schizophrenia: Intervention and Biomarkers
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: BEHAVIORAL: Motivational Interviewing and Cognitive Behavioral Therapy|BEHAVIORAL: Relaxation Skills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fruquintinib DDI Study With P-gp and BCRP Substrates
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Fruquintinib|DRUG: Dabigatran Etexilate|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Assess Safety and Efficacy of Venetoclax in Combination With Gilteritinib in Participants With Relapsed/Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: Venetoclax|DRUG: Gilteritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CYP19 Genetic Polymorphism & Aromatase Inhibitor(AI)
Status: UNKNOWN
Conditions: Breast Neoplasms|Arthralgia|Arthritis|Genetic Polymorphism
Interventions: DRUG: Aromatase Inhibitor(Femara or Arimidex)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Laparoscopic Ventral Hernia Repair by Heavy Weight or Lighter Weight Mesh (COMPOSIX-trial)
Status: TERMINATED
Conditions: Ventral Hernia
Interventions: PROCEDURE: Laparoscopic Ventral hernia repair by heavy weight mesh|PROCEDURE: Laparoscopic Ventral hernia repair by lighter weight mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrating eSAGE With EHR Data Using Machine Learning for the Early Detection and Monitoring of Cognitive Impairment in Individuals
Status: ENROLLING_BY_INVITATION
Conditions: Dementia|Alzheimer Disease|Mild Cognitive Impairment|Worried Well
Interventions: DIAGNOSTIC_TEST: electronic self administered gerocognitive examination (eSAGE)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunogenicity of a Quadrivalent Virus-Like Particles (VLP) Influenza Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Virus Diseases|RNA Virus Infections|Respiratory Tract Diseases|Respiratory Tract Infections
Interventions: BIOLOGICAL: 15 µg/strain of Quadrivalent VLP Vaccine|BIOLOGICAL: 30 µg/strain of Quadrivalent VLP Vaccine|BIOLOGICAL: 15 µg/strain of the licensed quadrivalent vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Allogeneic γδ T Cells Immunotherapy in r/r Non-Hodgkin's Lymphoma (NHL) or Peripheral T Cell Lymphomas (PTCL) Patients
Status: UNKNOWN
Conditions: Non-Hodgkin's Lymphoma (NHL)|Peripheral T Cell Lymphoma (PTCL)
Interventions: BIOLOGICAL: Ex-vivo expanded allogeneic γδT cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SomPsyNet - Prevention of Psychosocial Distress Consequences in Somatic Medicine: a Model for Collaborative Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Psychosocial Distress
Interventions: OTHER: Implementation of the SCCM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Efficacy and Safety of NexoBrid in Subjects With Thermal Burns
Status: COMPLETED
Conditions: Thermal Burns
Interventions: DRUG: NexoBrid|PROCEDURE: Standard of Care (SOC)|DRUG: Gel Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Circadian Rhythm After Anaesthesia in Children
Status: COMPLETED
Conditions: Circadian Rhythm Sleep Disorder|Circadian Rhythm Disorder Caused by Drug|Circadian Rhythm Sleep Disorder, Jet Lag Type|Jet Lag|Anesthesia|Sleep|Sleep Disorders, Circadian Rhythm|Sleep Disturbance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: GLP-1 Receptors in Normal Skin and Skin From Patients With Psoriasis
Status: UNKNOWN
Conditions: Reduction of Psoriasis Following Liraglutide Therapy in Terms of PASI and DLQI
Interventions: DRUG: Liraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Evaluating the Response to Two Antiretroviral Medication Regimens in HIV-Infected Pregnant Women, Who Begin Antiretroviral Therapy Between 20 and 36 Weeks of Pregnancy, for the Prevention of Mother-to-Child Transmission
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Lamivudine/zidovudine|DRUG: Efavirenz|DRUG: Raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Single-dose Dexmedetomidine on Airway Reflex in Adult With Oral Intubation After Thyroidectomy
Status: COMPLETED
Conditions: Coughing
Interventions: DRUG: Dexmedetomidine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder
Status: RECRUITING
Conditions: Schizophrenia|Schizo-Affective Disorder|Schizophreniform; Schizophrenic|Bipolar Disorder I|Bipolar Disorder II
Interventions: DRUG: BXCL501 80 Micrograms|DRUG: Placebo Film|DRUG: BXCL501 120 Micrograms|DRUG: BXCL501 60 Micrograms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NMA Haplo or MUD BMT for Newly Diagnosed Severe Aplastic Anemia
Status: COMPLETED
Conditions: Severe Aplastic Anemia|Aplastic Anemia|Bone Marrow Failure|Immunosuppression
Interventions: DRUG: Thymoglobulin|DRUG: Fludarabine|DRUG: Cyclophosphamide|RADIATION: Total body irradiation|DRUG: Tacrolimus|DRUG: Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Physical Activity in Young Adult Cancer Survivors Using mHealth and Adaptive Tailored Feedback Strategies
Status: COMPLETED
Conditions: Physical Activity|Neoplasms|Neoplasms by Site|Cancer
Interventions: BEHAVIORAL: Self-help|BEHAVIORAL: Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: HELPS Study - A Study of Peginterferon Alfa-2a (Pegasys) in Patients With Chronic Hepatitis C (CHC) and End-Stage Renal Disease (ESRD)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Peginterferon alfa-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2b/3 Study of TPX-115 on Partial-thickness Rotator Cuff Tear
Status: RECRUITING
Conditions: Partial Thickness Rotator Cuff Tear
Interventions: BIOLOGICAL: TPX-115|OTHER: Placebo (Saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: One-Time DNA Study for Vasculitis
Status: RECRUITING
Conditions: Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)|Giant Cell Arteritis|Granulomatosis With Polyangiitis (Wegener's)|Microscopic Polyangiitis|Polyarteritis Nodosa|Takayasu's Arteritis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Evaluate Safety and Tolerability After Multiple Oral Doses of AZD1656 in Type 2 Diabetes Patients on Top of Insulin
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: AZD1656|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Uridine Triphosphate (UTP) as an Aerosol Spray for Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: amiloride|DRUG: uridine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Protopic Ointment in Adult Atopic Eczema of the Face
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: tacrolimus 0.1%|DRUG: fluticasone 0.005 %
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Quality of CPR by Lay Rescuers With and Without Feedback Devices
Status: UNKNOWN
Conditions: Cardiac Arrest
Interventions: DEVICE: PocketCPR|DEVICE: Metronome|DEVICE: 110bpm Song
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Air-Q Intubating Laryngeal Airway Versus the Laryngeal Mask Airway (LMA)-Proseal
Status: COMPLETED
Conditions: Difficult Airway|Anesthesia; Functional
Interventions: DEVICE: Laryngeal Mask Airway (LMA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Perioperative Cognitive Protection - Cognitive Exercise and Cognitive Reserve (The Neurobics Trial)
Status: COMPLETED
Conditions: Delirium
Interventions: OTHER: Mini-Mental State Examination|OTHER: Self-Administered Gerocognitive Examination|OTHER: Geriatric Depression Scale|OTHER: Charlson Comorbidity Index|OTHER: Short Form 36 Health Survey|OTHER: Confusion Assessment Method|OTHER: Memorial Delirium Assessment Scale|OTHER: Postoperative Quality of Recovery Scale
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Randomized Trial on Effectiveness of ACTs in Ghana
Status: TERMINATED
Conditions: Malaria, Falciparum
Interventions: DRUG: Artesunate plus Amodiaquine|DRUG: Artemether-Lumefantrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dexmedetomidine on Left Ventricular Function in Coronary Artery Bypass Graft Surgery Outcome
Status: RECRUITING
Conditions: Effect of Drug in CABAG Patients
Interventions: DRUG: Dexmedetomidine|OTHER: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of 25-hydroxy Vitamin D Level in Caucasian Women Receiving Vitamin D Supplementation and Not Receiving Supplementation: a Randomized Controlled Trial.
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: vitamin D|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of IV Acetaminophen on Patients in the Neurocritical Care Unit
Status: COMPLETED
Conditions: Post-operative Craniotomy Patients|Carotid Endarterectomy and Carotid Artery Stenosis Patients|Post-op Spine Patients Admitted to the NCCU|Endovascular Patients Undergoing Intracranial Intervention|Traumatic Brain Injuries NPO for at Least 12 Hours
Interventions: DRUG: Intravenous acetaminophen|DRUG: Placebo for IV acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cost Effectiveness Analysis of a Randomized Control Trial of q3h vs. q4h Albuterol as Discharge Criteria From the Hospital for Pediatric Asthma Exacerbations
Status: WITHDRAWN
Conditions: Asthma in Children
Interventions: BEHAVIORAL: q3h albuterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Retrospective Cohort Study of the Effectiveness of the Prophylactic Vaccine Against the Human Papilloma Virus in the Prevention of Recurrence in Women Who Have Received an Excisional Therapy by HSIL / CIN.
Status: UNKNOWN
Conditions: Cervix, Dysplasia|HPV Infection|HPV Vaccine|Cervix Lesion
Interventions: DRUG: HPV vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Project to Use Community Health Workers to Reduce Maternal Deaths
Status: COMPLETED
Conditions: Maternal Mortality|Access to Health Care
Interventions: BEHAVIORAL: Village meeting and travel vouchers|DEVICE: Birth kit with misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Development and Feasibility Analysis of Verbal Expressive Skills Management Programme (VESMP) for Patients With Broca Aphasia
Status: COMPLETED
Conditions: Aphasia, Broca|Stroke
Interventions: OTHER: VESMP|OTHER: Traditional Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Value of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Prosthetic Valve Endocarditis
Status: COMPLETED
Conditions: Prosthetic Valve Endocarditis (PVE)
Interventions: DEVICE: 18F-FDG PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Safety and Efficacy of Two Treatments in the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne
Interventions: DRUG: Clindamycin and Benzoyl Peroxide Gel (combination)|DRUG: Clindamycin and Benzoyl Peroxide Gel (Reference) (combination)|DRUG: Placebo gel (combination)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AltaValve Early Feasibility Study Protocol
Status: RECRUITING
Conditions: Mitral Regurgitation|Mitral Insufficiency|Mitral Valve Incompetence|Mitral Valve Regurgitation|Mitral Incompetence
Interventions: DEVICE: AltaValve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiplex Laser vs. PDL (Pulsed Dye Laser ) in the Treatment of Surgical Scars
Status: COMPLETED
Conditions: Scar
Interventions: DEVICE: 595/1064nm Multiplex Laser|DEVICE: 595nm PDL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effects of BPN14770 on Scopolamine-induced Cognitive Impairment in Healthy Volunteers
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: BPN14770|DRUG: BPN14770 placebo|DRUG: Donepezil|DRUG: Donepezil placebo|DRUG: Scopolamine 0.6 MG/ML|DRUG: Scopolamine placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Adaptation and Evaluation of the WHO's ASSIST-linked Brief Intervention to Khat-Using Ethiopian University Students
Status: COMPLETED
Conditions: Khat Abuse
Interventions: BEHAVIORAL: ASSIST-linked Brief Intervention|BEHAVIORAL: Induction of Deliberative Mindset|BEHAVIORAL: Induction of Implemental Mindset
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anesthetic to Reduce Dysphagia After Anterior Cervical Discectomy and Fusion Surgery
Status: COMPLETED
Conditions: Dysphagia
Interventions: DRUG: bupivacaine hydrochloride 0.5% solution|DRUG: 0.9% NaCl solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Vitamin D & Levothyroxine Combination Versus Levothyroxine on Lipid Profile in Hypothyroidism
Status: RECRUITING
Conditions: Hypothyroidism Primary|Lipid Disorder|Dyslipidemias
Interventions: DRUG: Vitamin D|DRUG: Levothyroxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanical Ventilation During Cardiac Surgery
Status: UNKNOWN
Conditions: Respiratory Failure|Pneumothorax|Atelectasis|Aspiration Pneumonia|Bronchospasm
Interventions: PROCEDURE: Non-ventilation during CPB|PROCEDURE: Ventilation with CPAP|PROCEDURE: Ventilation with 5 act/minute|DEVICE: CPAP|DEVICE: Ventilator: 5 act/minute
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass
Status: COMPLETED
Conditions: Laparoscopic Surgery
Interventions: PROCEDURE: Sleeve gastrectomy|PROCEDURE: Laparoscopic Roux-en-Y gastric bypass
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Study to Evaluate the Sensitizing Potential of LEO 43204 Gel
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: LEO 43204|DRUG: LEO 43204 Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Single Dose Escalation Study of Bivatuzumab Mertansine in Female Patients With CD44v6 Positive Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: bivatuzumab mertansine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients
Status: COMPLETED
Conditions: Long QT Syndrome
Interventions: DRUG: Placebo|DRUG: Ranolazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Switch Strategy From Etravirine (ETR) to Doravirine (DOR) in Virologically-Suppressed HIV-1 Infected Adults With ETR-Resistance
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV-1-infection
Interventions: DRUG: Doravirine 100Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TAB008 Compared to Avastin® in Patients With EGFR Wild-type Non-squamous Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Efficacy
Interventions: DRUG: TAB008|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Pharmacokinetic Study (BF-BLOCK)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Budesonide/formoterol capsule.|DRUG: Budesonide/formoterol capsule for oral adm.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Citicoline in Eyedrops (OMK1) in Reducing the Progression of Glaucoma
Status: COMPLETED
Conditions: Glaucoma
Interventions: DEVICE: Citicoline eye drops (OMK1)|OTHER: Placebo Comparator: hypromellose based ocular lubricant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study: Preventing Adverse Remodelling Following Pacemaker Implantation
Status: NOT_YET_RECRUITING
Conditions: Pacemakers, Heart Failure
Interventions: DEVICE: Optimised programming|DRUG: Lisinopril|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Executive and Socio-cognitive Functions in Survivors of Primary Brain Tumor: Impact on Patients' Quality of Life
Status: UNKNOWN
Conditions: Primary Brain Tumor|Neurocognition|Quality of Life
Interventions: OTHER: Executive functions|OTHER: social cognition|OTHER: quality of life
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP
Status: RECRUITING
Conditions: Hypercapnic Respiratory Failure
Interventions: DEVICE: Average Volume-Assured Pressure Support (AVAPS)|DEVICE: Bilevel Positive Airway Pressure Spontaneous Timed (BIPAP S/T)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Utilising Volumetric Absorptive Microsampling (VAMS) Technology to Monitor Tacrolimus and Creatinine
Status: RECRUITING
Conditions: Kidney Transplant Rejection|Kidney Replacement
Interventions: DIAGNOSTIC_TEST: Mitra® device with VAMS® (volumetric absorptive microsampling) technology
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CoolCap Trial, Treatment of Perinatal Hypoxic-Ischemic Encephalopathy
Status: COMPLETED
Conditions: Neonatal Hypoxic-Ischemic Encephalopathy (HIE)
Interventions: DEVICE: Cool-Cap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes, Viscoelastic Properties and Central Pain Mechanisms After Eccentric Training in Neck/Shoulder Pain
Status: COMPLETED
Conditions: Neck Pain|Work-related Injury|Shoulder Pain
Interventions: DEVICE: Eccentric Training Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Vessels After Peripheral Block
Status: COMPLETED
Conditions: Anesthesia, Local|Vena Cava Syndrome (Inferior) (Superior)|Fluid Loss|Postoperative Pain
Interventions: PROCEDURE: Lateral Sagittal Infraclavicular Block|PROCEDURE: Inferior vena cava diameter >1.5 cm and Vena Cava Inferior Collapsibility Index (VCI-CI) < 50%|DIAGNOSTIC_TEST: Inferior vena cava diameter <1.5 cm and Vena Cava Inferior Collapsibility Index (VCI-CI) > 50%
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Imatinib Added to Chemotherapy in Treatment of Ph+ Acute Lymphoblastic Leukemia in Children
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Philadelphia Chromosome
Interventions: DRUG: Standard chemotherapy + Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine-UFTE Chemotherapy in Refractory Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic or Recurrent Colorectal Cancer|Refractory to Fluoropyrimidine, Oxaliplatin and Irinotecan|Salvage Chemotherapy
Interventions: DRUG: Gemcitabine and UFTE chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intravenous Amboxol Hydrochloride as an Adjunct Therapy for Severe Pneumonia in Critically Ill Patients
Status: COMPLETED
Conditions: Severe Pneumonia|Community-acquired Pneumonia|Hospital-acquired Pneumonia|Critical Illness
Interventions: DRUG: Ambroxol Hydrochloride|OTHER: Standard Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention to Promote Changes of Healthy Lifestyle (Physical Activity and Nutrition) During Gestation
Status: COMPLETED
Conditions: Excessive Weight Gain During Pregnancy|Gestational Diabetes
Interventions: BEHAVIORAL: Healthy lifestyle counseling|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cervical and Upper Thoracic Mobilization and Manipulation for Mechanical Neck Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: Cervical and thoracic mobilization|OTHER: cervical and thoracic manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Virtual Reality on Upper Extremity Function Post-operative Rotator Cuff Repair
Status: RECRUITING
Conditions: Rotator Cuff Impingement Syndrome|Rotator Cuff Tears|Rotator Cuff Injuries
Interventions: OTHER: conventional physical therapy training|DEVICE: Virtual Reality (VR) training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment-free Remission After Achieving Sustained MR4.5 on Nilotinib (ENESTop)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Diagnosis of Diastolic Dysfunction and Reliability of DSE in Detecting Stress Diastolic Dysfunction
Status: COMPLETED
Conditions: Diastolic Dysfunction
Interventions: DRUG: Dobutamine stress echo (DSE)|DRUG: Atropine bolus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Changes in Motor and Cognitive Function on Unilateral Spastic Cerebral Palsy, Associated With Videogame Therapy
Status: RECRUITING
Conditions: Cerebral Palsy, Spastic|Hemiplegia, Spastic
Interventions: DEVICE: Videogame therapy|OTHER: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of GNT0003 Following Imlifidase Pre-treatment in Severe Crigler-Najjar Syndrome
Status: NOT_YET_RECRUITING
Conditions: Crigler-Najjar Syndrome
Interventions: DRUG: Imlifidase|DRUG: GNT0003
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weight Gain Management in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Olanzapine Hydrochloride|DRUG: Nizatidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Sustained Weight Loss of Endoscopic Sleeve Gastroplasty With Diet Modification and Exercise
Status: COMPLETED
Conditions: Obesity
Interventions: PROCEDURE: Endoscopic Sleeve Gastroplasty|BEHAVIORAL: Diet and Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided PRP Versus Steroid Injections in Management of Carpal Tunnel Syndrome
Status: UNKNOWN
Conditions: Carpal Tunnel Syndrome
Interventions: DRUG: platlet rich plasma (PRP)|DRUG: Triamcinolone Acetonide|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Significance of 64-slice Multidetector Coronary CT Angiography to Evaluate the Prevalence and Severity of Coronary Artery Disease in Renal Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplant Recipient
Interventions: OTHER: 64-slice Multidetector coronary CT angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Refitting Somofilcon A Toric Contact Lens Wearers Into Fanfilcon A Toric Lenses for 4-weeks of Wear
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: somofilcon A toric contact lens|DEVICE: fanfilcon A toric contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Borderline Pancreas Study: FOLFIRINOX +SBRT
Status: COMPLETED
Conditions: Resectable Pancreatic Cancer
Interventions: OTHER: Chemotherapy(FOLFIRINOX) + SBRT prior to surgery if applicable|DRUG: -Oxaliplatin 85 mg/m2 IV on Day 1|DRUG: -Irinotecan 180 mg/m2 IV on Day 1|DRUG: -5-FU (Fluorouracil) 2,400 mg/m2 IV over 46-48 hours
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Cetaphil Restoraderm System Versus Standard Skin Care in Infants
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: OTHER: Cetaphil Restoraderm|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of HDR vs. LDR Brachytherapy as Monotherapy for Intermediate Risk Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: Low dose rate prostate brachytherapy|RADIATION: High Dose Rate prostate brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Appetite Suppression Trial With Polydextrose
Status: COMPLETED
Conditions: Body Weight|Non-restrained Eaters
Interventions: DIETARY_SUPPLEMENT: 12.5 g polydextrose|DIETARY_SUPPLEMENT: glucose syrup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: External Beam Radiation Therapy in Combination With Talquetamab for the Treatment of Multiple Myeloma Patients With Extramedullary Disease
Status: NOT_YET_RECRUITING
Conditions: Extramedullary Disease in Multiple Myeloma|Multiple Myeloma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Computed Tomography|OTHER: Electronic Health Record Review|RADIATION: External Beam Radiation Therapy|PROCEDURE: Image Guided Biopsy|PROCEDURE: Positron Emission Tomography|BIOLOGICAL: Talquetamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Intervention and Testosterone Replacement in Obese Seniors
Status: COMPLETED
Conditions: Obesity and Hypogonadism
Interventions: DRUG: Testosterone|OTHER: Lifestyle Therapy|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiology Prevention in Systemic Lupus Erythematosus (SLE)
Status: WITHDRAWN
Conditions: Systemic Lupus Erythematosus
Interventions: OTHER: Preventive Cardiology|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Lateral Trunk Support on Spinal Alignment in Spinal Cord Injured Persons
Status: COMPLETED
Conditions: Scoliosis|Spinal Cord Injury
Interventions: DEVICE: Lateral trunk support of wheelchair seating
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT