Clinical trial: Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer
Status: RECRUITING
Conditions: Clinical Stage I Esophageal Adenocarcinoma AJCC v8|Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8|Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage II Esophageal Adenocarcinoma AJCC v8|Clinical Stage II Esophageal Squamous Cell Carcinoma AJCC v8|Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8|Clinical Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IIB Esophageal Adenocarcinoma AJCC v8|Clinical Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage III Esophageal Adenocarcinoma AJCC v8|Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC v8|Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8|Clinical Stage IVA Esophageal Squamous Cell Carcinoma AJCC v8|Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage I Esophageal Adenocarcinoma AJCC v8|Pathologic Stage I Esophageal Squamous Cell Carcinoma AJCC v8|Pathologic Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IA Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IA Esophageal Squamous Cell Carcinoma AJCC v8|Pathologic Stage IA Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IB Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IB Esophageal Squamous Cell Carcinoma AJCC v8|Pathologic Stage IB Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IC Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IC Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage II Esophageal Adenocarcinoma AJCC v8|Pathologic Stage II Esophageal Squamous Cell Carcinoma AJCC v8|Pathologic Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIA Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IIA Esophageal Squamous Cell Carcinoma AJCC v8|Pathologic Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIB Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IIB Esophageal Squamous Cell Carcinoma AJCC v8|Pathologic Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage III Esophageal Adenocarcinoma AJCC v8|Pathologic Stage III Esophageal Squamous Cell Carcinoma AJCC v8|Pathologic Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IIIA Esophageal Squamous Cell Carcinoma AJCC v8|Pathologic Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IIIB Esophageal Squamous Cell Carcinoma AJCC v8|Pathologic Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IVA Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IVA Esophageal Squamous Cell Carcinoma AJCC v8|Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage I Esophageal Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage I Esophageal Squamous Cell Carcinoma AJCC v8|Postneoadjuvant Therapy Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage II Esophageal Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage II Esophageal Squamous Cell Carcinoma AJCC v8|Postneoadjuvant Therapy Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage III Esophageal Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage III Esophageal Squamous Cell Carcinoma AJCC v8|Postneoadjuvant Therapy Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IIIA Esophageal Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IIIA Esophageal Squamous Cell Carcinoma AJCC v8|Postneoadjuvant Therapy Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IIIB Esophageal Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IIIB Esophageal Squamous Cell Carcinoma AJCC v8|Postneoadjuvant Therapy Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IVA Esophageal Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IVA Esophageal Squamous Cell Carcinoma AJCC v8|Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8|Thoracic Esophagus Squamous Cell Carcinoma
Interventions: DRUG: Carboplatin|PROCEDURE: Esophagectomy|RADIATION: Intensity-Modulated Radiation Therapy|DRUG: Paclitaxel|RADIATION: Proton Beam Radiation Therapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: FOLFOX regimen|DRUG: CAPOX regimen|DRUG: Docetaxel|DRUG: 5FU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT