pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DRUG: AMR101|DRUG: Placebo|DRUG: Statin therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial to Investigate Safety/Tolerability and Pharmacokinetics of DA-1229_01 Compared to Co-administration of Evogliptin 5 mg and Metformin XR 1000 mg, and to Evaluate the Effect of Food on the Pharmacokinetics of DA-1229_01 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: DA-1229_01|DRUG: E+M|DRUG: DA-1229_01 fast|DRUG: DA-1229_01 fed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Peripheral Intravenous Catheter Insertion in the Hospitalized Patient: Long vs. Short Axis Placement
Status: WITHDRAWN
Conditions: Need for IV Access
Interventions: DEVICE: Long axis IV placement with ultrasound|DEVICE: Short axis IV placement with ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of a Protease Activated Receptor-4 Antagonist Being Tested to Reduce the Chances of Having Additional Strokes or "Mini Strokes"
Status: COMPLETED
Conditions: Thrombosis
Interventions: DRUG: BMS-986141|DRUG: Aspirin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single-blind Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Hantaan Puumala Virus DNA Vaccine
Status: COMPLETED
Conditions: Hantaan Virus
Interventions: BIOLOGICAL: Hantaan Vaccine:|BIOLOGICAL: Puumala Vaccine|BIOLOGICAL: Hantaan/Puumala Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Efficacy and Safety of MEDI-563 in Adults With Uncontrolled Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: Benralizumab 2 mg|BIOLOGICAL: Benralizumab 20 mg|BIOLOGICAL: Benralizumab 100 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Prophylactic TMR and RPNI on Neuroma and Phantom Limb Pain
Status: WITHDRAWN
Conditions: Amputation|Neuroma Amputation|Phantom Limb Pain|Residual Limbs
Interventions: PROCEDURE: Targeted Muscle Re-innervation|PROCEDURE: Regenerative Peripheral Nerve Interface|PROCEDURE: Standard Post-Amputation Surgical Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Letrozole, Anastrozole, Exemestane, or Tamoxifen Citrate in Treating Postmenopausal Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: anastrozole|DRUG: exemestane|DRUG: letrozole|DRUG: tamoxifen citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bicalutamide With or Without Akt Inhibitor MK2206 in Treating Patients With Previously Treated Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Prostate Carcinoma|Stage I Prostate Cancer AJCC v7|Stage IIA Prostate Cancer AJCC v7|Stage IIB Prostate Cancer AJCC v7|Stage III Prostate Cancer AJCC v7
Interventions: DRUG: Akt Inhibitor MK2206|DRUG: Bicalutamide|OTHER: Clinical Observation|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Relative Oral Bioavailability of Seltorexant (JNJ-42847922) After Administration of 3 Different Formulations in Healthy Participants Under Fasted and Semi-fasted Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Seltorexant 40 mg|DRUG: Seltorexant 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Mechanical Ventilation Controlled by the Electrical Activity of the Patient's Diaphragm - Effects on Cardiac Performance
Status: COMPLETED
Conditions: Respiratory Failure|Cardiac Failure
Interventions: DEVICE: Neurally adjusted ventilatory assist (NAVA) provided by a commercially available mechanical ventilator (Servo i, Maquet Critical Care, Solna, Sweden).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of LBH589B in Adult Patients With Refractory Chronic Myeloid Leukemia in Accelerated or Blast Phase
Status: TERMINATED
Conditions: Leukemia, Myeloid, Chronic
Interventions: DRUG: LBH589
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Two Extended-Release Formulations of Methylphenidate in Children With Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cervico-vestibular Rehabilitation for Mild Traumatic Brain Injury
Status: COMPLETED
Conditions: Post-Concussion Syndrome|Mild Traumatic Brain Injury|Vestibular Disorder|Whiplash Injuries|Concussion, Brain
Interventions: OTHER: Conventional approach|OTHER: Personalized rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence and Risk Factors of Weaning-induced Cardiac Dysfunction: Results From a Multicenter, Observational Study
Status: COMPLETED
Conditions: Weaning Failure|Weaning-induced Pulmonary Edema|Spontaneous Breathing Trial
Interventions: PROCEDURE: Spontaneous breathing trial
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness and Cost-Effectiveness Study of Medical Nutrition in Malnourished Patients in Spain
Status: TERMINATED
Conditions: Malnutrition|Nutrition Disorders
Interventions: DIETARY_SUPPLEMENT: Oral nutrition supplement|OTHER: Nutritional advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CBD (Cannabidiol)/THC (Tetrahydrocannabinol) Solution as a Pharmacological Strategy for Patients With Fibromyalgia (FibroCann)
Status: UNKNOWN
Conditions: Fibromyalgia
Interventions: DRUG: cannabidiol and tetrahydrocannabinol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Single-Dose, Open-Label, Randomized, Food Effect and Blinded, Randomized, Dose Proportionality Study in Healthy Volunteers With Bardoxolone Methyl
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: bardoxolone methyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hyperalgesia, Persistent Pain, and Fentanyl Dosing in On-Pump Coronary Artery Bypass Grafting
Status: COMPLETED
Conditions: Hyperalgesia|Opioid Use|Pain, Postoperative|Pain, Chronic
Interventions: DRUG: Fentanyl dosing schemes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Effects and Safety of ALK4290 in Patients With Newly Diagnosed Wet Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Wet Age-related Macular Degeneration
Interventions: DRUG: ALK4290
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Norwegian Sonothrombolysis in Acute Stroke Study Part 2
Status: TERMINATED
Conditions: Ischemic Stroke
Interventions: OTHER: Ultrasound|OTHER: Sham ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Bone Marrow Concentrate for Treatment of Alar, Accessory, and Transverse Ligament Injuries
Status: RECRUITING
Conditions: Craniocervical Injuries
Interventions: BIOLOGICAL: Bone Marrow Concentrate treatment|OTHER: Sham Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Novel Individualised Treatment Strategy for Carbapenem-Resistant Gram-Negative Bacteria Infections
Status: UNKNOWN
Conditions: Antibiotic Therapy
Interventions: DIAGNOSTIC_TEST: In vitro antibiotic combination testing (iACT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Live Birth Rate Between PPOS and GnRH Antagonist Protocol in Patients With Anticipated High Ovarian Response
Status: COMPLETED
Conditions: IVF|GnRH Antagonist|PPOS
Interventions: DRUG: Progesterone|DRUG: GnRH Antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Progressive vs. Non-progressive Water-based Aerobic Training on Type 2 Diabetes Control: a Randomized Clinical Trial
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Progressive water-based aerobic training|OTHER: Non-progressive aerobic training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effects of Vitamin E, Ursodeoxycholic Acid and Pentoxyfylline on Egyptian Non-alcoholic Steatohepatitis (NASH) Patients
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis (NASH)
Interventions: DRUG: Vitamin E|DRUG: Ursodeoxycholic acid|DRUG: Pentoxifylline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Multi-Center Prospective Randomized Trial Comparing Standard Esophagectomy Against Chemo-Radiotherapy for Treatment of Squamous Esophageal Cancer - Early Results From the Chinese University Research Group for Esophageal Cancer (CURE)
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: PROCEDURE: Esophagectomy|PROCEDURE: Chemoradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Usefulness of Non TNF Usage in RA Patients
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Drug: "Salirumab"|DRUG: Drug: "Tocilizmab"|DRUG: Drug: "Abatacept"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: LED Light Therapy to Improve Cognitive & Psychosocial Function in TBI-PTSD Veterans
Status: WITHDRAWN
Conditions: Traumatic Brain Injury (TBI)|Post-traumatic Stress Disorder (PTSD)
Interventions: DEVICE: Photomedex Sham Helmet with Red/Near-Infrared Light-Emitting Diodes (LEDs) that are not turned on
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamics and Pharmacokinetics of Insulin Detemir in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir|DRUG: insulin NPH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Mobile Application Supported Diabetes Education On Type 2 Diabetes Self-Management And Blood Sugar Level
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Education|Mobile Applications|Self-Management
Interventions: OTHER: Mobile Application Supported Nutrition and Diabetes Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study of Efficacy and Safety of Chung A Won in Women's Patients With Osteoporosis
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Experimental
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Pulsatile Cuts Stendo3 on Vascular Function Patients With Diabetes Type 2
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DEVICE: Combination pulsatile Stendo3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Instrument- Assisted Soft Tissue Mobilization on Upper Crossed Syndrome
Status: NOT_YET_RECRUITING
Conditions: Upper Cross Syndrome
Interventions: OTHER: Release group|OTHER: strength exercises and stretching for upper crossed syndrome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Guidelines for Drug Therapy of Hypertension: Multi-Site Implementation
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: ATHENA Decision Support System, An Automated Clinical Decision Support System for Health Care Providers|BEHAVIORAL: Profiling performance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: ANTES B+ Clinical Trial
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Trelegy Ellipta 100/62.5/25Mcg Inh 30D|DRUG: Brimica|DRUG: Duaklir|DRUG: Ultibro|DRUG: Ulunar|DRUG: Xoterna|DRUG: Anoro|DRUG: Laventair|DRUG: Spiolto Respimat|DRUG: Yanimo|DRUG: Foradil|DRUG: Broncoral|DRUG: Formoterol stada|DRUG: Oxis|DRUG: Formatris|DRUG: Formoterol Aldo|DRUG: Onbrez|DRUG: Oslif|DRUG: Hirobriz|DRUG: Striverdi|DRUG: Beglan|DRUG: Betamican|DRUG: Inaspir|DRUG: Serevent|DRUG: Soltel|DRUG: Eklira|DRUG: Bretaris|DRUG: Seebri|DRUG: Tovanor|DRUG: Enurev|DRUG: Spiriva|DRUG: Tavulus|DRUG: Sirkava|DRUG: Braltus|DRUG: Gregal|DRUG: Incruse|DRUG: Rolufta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)
Status: TERMINATED
Conditions: Gestational Trophoblastic Neoplasia|Choriocarcinoma|Placental Site Trophoblastic Tumor|Epithelioid Trophoblastic Tumor
Interventions: DRUG: TRC105|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction Chemotherapy Followed by Concurrent Chemoradiotherapy in Patients With LA-NPC
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of I/v Nalbuphine v/s Iv Lignocain in Attanuation of Pressor Responseduring Laryngeoscopy and Intubation in Middle Age Patient Planned for Thyroid Surgery
Status: NOT_YET_RECRUITING
Conditions: Hemodynamic Stability
Interventions: DRUG: Lignocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Goserelin (Zoladex®) in Spinal and Bulbar Muscular Atrophy
Status: COMPLETED
Conditions: Spinobulbar Muscular Atrophy|Kennedy's Disease
Interventions: DRUG: Goserelin|PROCEDURE: Electrophysiologic study|PROCEDURE: tissue biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of MAP and EtCO2 on Venous Sinus Pressures
Status: COMPLETED
Conditions: Idiopathic Intracranial Hypertension
Interventions: PROCEDURE: Venous Sinus Stenting|OTHER: Adjustment to end-tidal carbon dioxide concentrations ( 38-40 mmHg range)|OTHER: Adjustment to Mean Arterial Pressure (100-110 mmHg range)|OTHER: Adjustment to Mean Arterial Pressure (60-80 mmHg range)|OTHER: Adjustment to end-tidal carbon dioxide concentrations (24-26 mmHg range)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Optimizing the Antibiotic Treatment of Uncomplicated Acute Appendicitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Appendicitis
Interventions: DRUG: Ertapenem|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Catheter Ablation of Atrial Fibrillation in Patients With Pulmonary Hypertension Hypertension: a Randomised Study
Status: COMPLETED
Conditions: Atrial Fibrillation|Pulmonary Hypertension
Interventions: PROCEDURE: Catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Food Effects on Pharmacokinetics of SY-5007 Tablets in Healthy Subjects
Status: NOT_YET_RECRUITING
Conditions: Health Subjects
Interventions: DRUG: SY-5007|DRUG: SY-5007
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy as an Immunological Booster in Patients With Metastatic Melanoma or Renal Cell Carcinoma Treated With High-dose Interleukin-2
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Renal Cell Cancer|Malignant Melanoma, Metastatic
Interventions: OTHER: Boost of radiotherapy + high dose IL-2 treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Ischemic Conditioning in ST-elevation Myocardial Infarction as Adjuvant to Primary Angioplasty
Status: COMPLETED
Conditions: ST Elevation Myocardial Infarction
Interventions: OTHER: Remote ischaemic conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Midostaurin in MRD (Minimal Residual Disease) Positive Acute Myeloid Leukemia After Allogeneic Stem Cell Transplantation
Status: TERMINATED
Conditions: Acute Myeloid Leukemia, Adult
Interventions: DRUG: Midostaurin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Efficacy Study of Radotinib in Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: Radotinib HCl 50 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Implant Placement in the Preserved Socket Using Socket Shield Technique With Autogenous Dentin Graft Versus Preserved Socket Using Socket Shield With Alloplast
Status: UNKNOWN
Conditions: Teeth Extraction|Tooth Socket
Interventions: PROCEDURE: socket shield technique with autogenous dentin graft|PROCEDURE: socket shield technique with alloplast graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sertraline Versus Escitalopram in South Asian Participants With Moderate to Severe Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Sertraline|DRUG: Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Droplet Digital PCR Rapid Detection Method and Precise Diagnosis and Treatment for Suspected Sepsis
Status: UNKNOWN
Conditions: Sepsis|Septic Shock
Interventions: DIAGNOSTIC_TEST: droplet digital PCR method|DIAGNOSTIC_TEST: blood culture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treatment of Insertional Achilles Tendinopathy by Hyaluronic Acid Injection
Status: UNKNOWN
Conditions: Insertional Achilles Tendinitis
Interventions: DRUG: Injection of Hyaluronic Acid -" SYNVISC" (hylan G-F 20)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRCT of FICB vs LAI for Hip Arthroscopy
Status: COMPLETED
Conditions: Femoroacetabular Impingement
Interventions: PROCEDURE: Fascia Iliaca Compartment Block (FICB)|PROCEDURE: Local Anaesthetic Infiltration (LAI)|DRUG: Levobupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Botulinum Toxin and Recovery of Hand Function After Stroke
Status: COMPLETED
Conditions: Stroke With Hemiparesis
Interventions: DRUG: Botulinum Toxin commonly known as BOTOX®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Body Composition After Laparoscopic Gastrectomy for Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer|Benign Gastric Tumor
Interventions: PROCEDURE: Laparoscopic gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluating the Safety and Efficacy of Oral Encapsulated Microbiota Transplantation Therapy in Peanut Allergic Patients
Status: RECRUITING
Conditions: Allergy, Peanut|Peanut Allergy|Peanut Hypersensitivity|Peanut-Induced Anaphylaxis|Food Allergy|Food Allergy Peanut
Interventions: BIOLOGICAL: Microbial Transplantation Therapy|DRUG: Antibiotic|OTHER: Placebo (in place of MTT)|OTHER: Placebo (in place of antibiotics)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Opti-Free III (FID 109182) Compared to Opti-Free Plus® in Japan
Status: COMPLETED
Conditions: Corneal Staining
Interventions: DEVICE: FID 109182|DEVICE: Opti-Free Plus|DEVICE: Senofilcon A contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Study to Evaluate the Effects of ONO-2506 Intravenous Infusion in Patients With Acute Ischemic Stroke
Status: TERMINATED
Conditions: Cerebrovascular Accident
Interventions: DRUG: ONO-2506
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: EZCast-DFU Study With Portal for Application of Topical Medications
Status: COMPLETED
Conditions: Foot Ulcer|Diabetic Foot
Interventions: DRUG: Collagenase ointment|DEVICE: Modified Contact Cast System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of LDE225 With Gemcitabine and Nab-paclitaxel in Patients With Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: gemcitabine and nab paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of Celecoxib In Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Celecoxib|DRUG: Loxoprofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study MK0767 and Metformin in Type 2 Diabetic Patients (0767-020)
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: MK0767|DRUG: Comparator: placebo (unspecified)|DRUG: Comparator: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Whole Day Matters After Stroke (BIG-STEPS)
Status: RECRUITING
Conditions: Stroke
Interventions: BEHAVIORAL: Behaviour- & Imaging-Guided Stepping Training Early Post-Stroke (BIG STEPS) intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 26 Weeks' Dietary Supplementation With DHA- and EPA-enriched Oils on Sleep Efficiency in Healthy Adults
Status: COMPLETED
Conditions: Sleep
Interventions: DIETARY_SUPPLEMENT: EPA-rich|DIETARY_SUPPLEMENT: DHA-rich|DIETARY_SUPPLEMENT: Olive oil Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective, Multi-center and Randomized Controlled Trial of Tianyi Revascularization Device in Acute Ischemic Stroke
Status: COMPLETED
Conditions: AIS|Acute Ischemic Stroke|Large Vessel Occlusion|Thrombectomy
Interventions: DEVICE: Tianyi Revascularization Device|DEVICE: Solitaire FR Revascularization Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dynamic Cerebral Autoregulation of Remote Ischemic Conditioning Combined With Intravenous Thrombolysis for Acute Ischemic Stroke
Status: COMPLETED
Conditions: Remote Ischemic Conditioning
Interventions: PROCEDURE: remote ischemic conditioning|PROCEDURE: sham remote ischemic conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigate Safety, Tolerability and Pharmacokinetics for Single Doses of NNC9204-0530 Alone and in Combination With Liraglutide in Overweight to Obese But Otherwise Healthy Male Subjects
Status: COMPLETED
Conditions: Metabolism and Nutrition Disorder|Obesity
Interventions: DRUG: NNC9204-0530|DRUG: liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ozurdex Endophtamitis Cohort, Prognostic Assessment at 12 Months
Status: RECRUITING
Conditions: Endophthalmitis
Interventions: OTHER: Visual acuity analysis|OTHER: Intraocular pressure analysis|OTHER: Analysis of optical coherence tomography (OCT) images|OTHER: Analysis of retinograms
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lymphovenous Anastomosis for Breast Cancer Lymphedema
Status: RECRUITING
Conditions: Lymphedema|Lymphedema Arm|Breast Cancer Lymphedema|Lymphedema, Secondary|Lymphedema; Surgical|Lymphedema of Upper Limb|Lymphedema, Breast Cancer
Interventions: PROCEDURE: Lymphovenous anastomosis (LVA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine Safety & Efficacy of Autologous Human Platelet Lysate (HPL) in Facial Wrinkles(Nasolabial Folds)
Status: UNKNOWN
Conditions: Facial Wrinkles (Nasolabial Folds)
Interventions: OTHER: Autologous Human Platelet Lysate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of A Novel Ointment to Treat Plaque Type Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: AN2728|DRUG: AN2728 Ointment Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Robot-assisted With Laparoscopic-assisted Modified Soave Procedure for Classical Hirschsprung Disease
Status: RECRUITING
Conditions: Hirschsprung Disease
Interventions: PROCEDURE: RAMS|PROCEDURE: LAMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ratio of ''Central Venous-to-Arterial Co2 Gap'' to ''Arterial-to-Central Venous O2 Content Gap'' in Septic Shock
Status: UNKNOWN
Conditions: Septic Shock
Interventions: OTHER: Fluid challenge (0.9 % NaCl)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Intradiscal Injection of BM-MSC in Subjects With Chronic Low Back Pain (LBP) Due to Lumbar Degenerative Disc Disease (DDD) Unresponsive
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Low Back Pain|Degenerative Disc Disease (DDD)
Interventions: DRUG: Allogenic BM-MSCs Injection|OTHER: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Imaging of Bone Metastases in Prostate Cancer Patients
Status: UNKNOWN
Conditions: Prostate Cancer Metastatic to Bone
Interventions: DIAGNOSTIC_TEST: WB-MRI|DIAGNOSTIC_TEST: SPECT-CT|DIAGNOSTIC_TEST: Cholin-PET-CT|DIAGNOSTIC_TEST: PSMA-PET-CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Randomized Phase I Study of a Hepatitis B Antigen Combined With IMP321
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: hepatitis B antigen (without alum) plus IMP321|BIOLOGICAL: hepatitis B antigen alone (without alum)|BIOLOGICAL: Engerix B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Antimicrobial Effectiveness of CHG/IPA
Status: COMPLETED
Conditions: Microbial Colonization
Interventions: COMBINATION_PRODUCT: Investigational Product|OTHER: Reference Standard|COMBINATION_PRODUCT: Active Comparator|OTHER: Negative Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability and Pharmacokinetics of Multiple Doses of ZGN-433 in Obese Female Volunteers
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: ZGN-433
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Oral Iron on the Prevention of Iron Deficiency Anemia in Obese Pregnant
Status: COMPLETED
Conditions: Anemia of Pregnancy
Interventions: DRUG: Iron|DIAGNOSTIC_TEST: Complete blood count|DIAGNOSTIC_TEST: Serum ferritin|DIAGNOSTIC_TEST: Serum hepcidin|DIAGNOSTIC_TEST: Serum Iron|DIAGNOSTIC_TEST: Serum total iron binding capacity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of Avoidance of Bladder Catheters in Stroke Patients to Avoid Urinary Tract Infections
Status: TERMINATED
Conditions: Stroke|Catheter Associated Urinary Tract Infection
Interventions: BEHAVIORAL: Nursing protocol to avoid Foley catheter placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A First in Human Trial Evaluating THB335 in Healthy Participants
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: THB335 single dose|DRUG: Single dose placebo|DRUG: THB335 fasted/fed|DRUG: Placebo fasted/fed|DRUG: THB335 multiple dose|DRUG: Multiple dose placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Anti-osteoporotic Medications on Nonalcoholic Fatty Liver Disease
Status: RECRUITING
Conditions: Nonalcoholic Fatty Liver|Osteoporosis, Postmenopausal
Interventions: DRUG: Denosumab|DRUG: Alendronate Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Therapy for Chronic Kidney Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Kidney Diseases|Diabetes Mellitus, Type 2|Diabetes Mellitus, Type 1|Diabetes Mellitus|Diabetic Nephropathies
Interventions: DRUG: Allogeneic adipose-derived mesenchymal stem cells (MSC)-Single Infusion|DRUG: Allogeneic adipose-derived mesenchymal stem cells (MSC)-Two Infusions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: NK Cells in Cord Blood Transplantation
Status: UNKNOWN
Conditions: Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Acute Biphenotypic Leukemia|Acute Lymphoblastic Leukemia in Remission|Acute Myeloid Leukemia in Remission|Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|DS Stage II Plasma Cell Myeloma|DS Stage III Plasma Cell Myeloma|High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements|ISS Stage II Plasma Cell Myeloma|ISS Stage III Plasma Cell Myeloma|Myelodysplastic Syndrome|Recurrent Acute Lymphoblastic Leukemia|Recurrent Acute Myeloid Leukemia|Recurrent Chronic Lymphocytic Leukemia|Recurrent Hodgkin Lymphoma|Recurrent Non-Hodgkin Lymphoma|Recurrent Small Lymphocytic Lymphoma|Refractory Acute Lymphoblastic Leukemia|Refractory Chronic Lymphocytic Leukemia|Refractory Hodgkin Lymphoma|Refractory Non-Hodgkin Lymphoma|Refractory Small Lymphocytic Lymphoma|Secondary Acute Myeloid Leukemia|Therapy-Related Acute Myeloid Leukemia|Therapy-Related Myelodysplastic Syndrome
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|DRUG: Lenalidomide|DRUG: Melphalan|DRUG: Mycophenolate Mofetil|BIOLOGICAL: Natural Killer Cell Therapy|BIOLOGICAL: Rituximab|DRUG: Tacrolimus|RADIATION: Total-Body Irradiation|PROCEDURE: Umbilical Cord Blood Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Impact of Pelvic Floor Prehabilitation Using Biofeedback on the Severity of the Low Anterior Resection Syndrome in Patients Undergoing a Total Mesorectal Excision for Rectal Cancer"
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: PROCEDURE: Pelvic floor prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Dose Study of D1971a in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DS-1971a|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Intervention Delivered by Text Message to Increase the Acceptability of Effective Contraception Among Young Women in Palestine
Status: COMPLETED
Conditions: Contraception
Interventions: BEHAVIORAL: Contraceptive text messages|OTHER: Text messages not about contraception
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Long-term Extension of Study GNC-401
Status: TERMINATED
Conditions: Multiple Sclerosis
Interventions: DRUG: Temelimab 18 mg/kg|DRUG: Temelimab 36mg/kg|DRUG: Temelimab 54 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Ranging Study of SLIT Tablets of House Dust Mite Allergen Extracts (HDM) in Adults With HDM-associated Allergic Asthma
Status: COMPLETED
Conditions: Asthma|House Dust Mite Allergy
Interventions: BIOLOGICAL: SLIT tablets of HDM allergen extracts, 3 different doses (A)|BIOLOGICAL: SLIT tablets of HDM allergen extracts, 3 different doses (B)|BIOLOGICAL: SLIT tablets of HDM allergen extracts, 3 different doses (C)|BIOLOGICAL: Placebo matching the SLIT tablets of HDM allergen extracts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cisplatin/Carboplatin and Etoposide With or Without Nivolumab in Treating Patients With Extensive Stage Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Extensive Stage Lung Small Cell Carcinoma|Recurrent Lung Small Cell Carcinoma
Interventions: DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Etoposide|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of an Omega-3 Fatty Acid-based Supplement on Healthy Ageing
Status: RECRUITING
Conditions: Healthy Aging|Ageing Well
Interventions: DIETARY_SUPPLEMENT: AvailOm|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Ph1 Study of Valortim and Ciprofloxacin in Humans
Status: SUSPENDED
Conditions: Anthrax
Interventions: DRUG: Ciprofloxacin and Valortim|DRUG: Placebo Antibiotic and Valortim|OTHER: Placebo Antibiotic and Placebo Valortim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Utilizing All Health System Contacts to Offer Postpartum Family Planning (PPFP) in Ethiopia
Status: COMPLETED
Conditions: Contraceptive Usage|Postpartum Family Planning|Contraception|Prenatal Care|Pregnancy
Interventions: BEHAVIORAL: Health centers provide PPFP counseling and services|BEHAVIORAL: HEWs provide PPFP counseling and services|BEHAVIORAL: Volunteers (Development Army) promote PPFP|BEHAVIORAL: Health centers conduct data reviews|BEHAVIORAL: HEWs and volunteers track PPFP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact of Budesonide Irrigations on Patients With Chronic Rhinosinusitis and Impact on Sinus Surgery Rates
Status: WITHDRAWN
Conditions: Chronic Sinus Infection|Chronic Sinusitis|Chronic Sinusitis - Ethmoidal, Posterior|Chronic Sinus Congestion
Interventions: DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Avelumab and Azacitidine in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Avelumab|DRUG: Azacitidine|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pegylated Interferon-Alfa 2b in Combination With PUVA Therapy In CTCL
Status: TERMINATED
Conditions: Lymphoma
Interventions: BIOLOGICAL: Pegylated interferon α-2b|OTHER: Psoralens with ultraviolet light A|OTHER: Narrowband-ultraviolet light B
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Harvesting in Coronary Artery Bypass Grafting.
Status: COMPLETED
Conditions: Coronary Bypass Stenosis|Graft Infection
Interventions: DEVICE: Medtronic endoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Placebo Controlled Trial to Evaluate Zinc for the Treatment of COVID-19 in the Outpatient Setting
Status: COMPLETED
Conditions: Corona Virus Infection
Interventions: DIETARY_SUPPLEMENT: Zinc Sulfate 220 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Liraglutide on the Metabolic Profile in Patients With Type 2 Diabetes and Cardiovascular Disease
Status: WITHDRAWN
Conditions: Type 2 Diabetes|Cardiovascular Diseases
Interventions: DRUG: Liraglutide Pen Injector [Victoza]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Campath-1H Induction to Allow Steroid Free Immunosuppression in Pediatric Renal Transplantation
Status: TERMINATED
Conditions: Disorder Related to Renal Transplantation
Interventions: DRUG: Campath-1H
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Research on the Efficacy of the "T.O.P. Computer Training" Procedure in the Treatment of Alcohol Dependence
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: BEHAVIORAL: active approach avoidance training and sham visual probe training|BEHAVIORAL: sham approach avoidance training and active visual probe training|BEHAVIORAL: active approach avoidance training and active visual probe training|BEHAVIORAL: sham approach avoidance training and sham visual probe training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of 30 mg/kg Amikacin and 8 mg/kg Gentamicin on Serum Concentrations in Critically Ill Patients With Severe Sepsis
Status: COMPLETED
Conditions: Sepsis
Interventions: DRUG: 30 mg/kg amikacin or 8 mg/kg gentamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Randomized Antibiotic Administration in Percutaneous Nephrolithotomy
Status: COMPLETED
Conditions: Kidney Stones
Interventions: DRUG: cephalosporins|DRUG: Fluoroquinolones|DRUG: Clindamycin|DRUG: Ampicillin/Gentamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Safety and Performance of the Atalante System With Patients With Lower Limb Paralysis
Status: COMPLETED
Conditions: Spinal Cord Injuries|Paraplegia|Paralysis, Lower Limbs|Lower Extremity|Robotics
Interventions: DEVICE: Use of the Atalante exoskeleton
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Determine Efficacy and Safety of CC-486 With Nab-Paclitaxel Versus Nab-Paclitaxel in Patients With Chemotherapy naïve Metastatic Melanoma
Status: WITHDRAWN
Conditions: Metastatic Melanoma
Interventions: DRUG: Abraxane|DRUG: Abraxane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional and Structural Assessment of Endobronchial Valve Recipients Using Dynamic Hyperpolarized Xenon-129 MRI
Status: NOT_YET_RECRUITING
Conditions: COPD
Interventions: DRUG: MagniXene Hyperpolarized Xenon MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ACTIV-6: COVID-19 Study of Repurposed Medications - Arm A (Ivermectin 400)
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Ivermectin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Novel Protocol for Supportive Periodontal Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Periodontitis
Interventions: PROCEDURE: Control (standard protocol)|PROCEDURE: Test (Guided Biofilm management)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comprehensive Care Plan for Pediatric Patients With Vaso-Occlusive Crises
Status: TERMINATED
Conditions: Sickle Cell Disease|Sickle Cell Crisis|Vaso-Occlusive Crises
Interventions: OTHER: Comprehensive Care Plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gut Microbiota Reconstruction for NSCLC Immunotherapy
Status: UNKNOWN
Conditions: Non-Small Cell Lung Cancer
Interventions: PROCEDURE: Capsulized Fecal Microbiota Transplant|DRUG: Anti-programmed cell death protein 1/programmed death-ligand 1 monoclonal antibody|DRUG: Platinum based chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examination of Implant´s Safety in an Electronic and Magnetic Field Environment
Status: COMPLETED
Conditions: Disorder of Cardiac Pacemaker System|Disorder of Implantable Defibrillator|Cardiac Arrhythmia
Interventions: DEVICE: Magnetic and electric field´s impact on the implant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p