pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of CTO1681 for the Prevention and Treatment of CRS in DLBCL Patients Receiving CAR T-Cell Therapy
Status: RECRUITING
Conditions: Cytokine Release Syndrome
Interventions: DRUG: CTO1681 10 μg|DRUG: CTO1681 20 μg|DRUG: CTO1681 30 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iberdomide, Daratumumab, Carfilzomib, and Dexamethasone (Iber-KDd) in Patients With Relapsed/Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Refractory Multiple Myeloma|Relapsed Multiple Myeloma
Interventions: DRUG: Iberdomide|DRUG: Carfilzomib|DRUG: Daratumumab|DRUG: Dexamethasone|DRUG: Acetaminophen|DRUG: Diphenhydramine|DRUG: Montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Versus Open Left Hemihepatectomy for Liver Benign Lesions
Status: COMPLETED
Conditions: Benign Lesions in Left Liver
Interventions: PROCEDURE: Laparoscopic left hemihepatectomy|PROCEDURE: Open left hemihepatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Ranging Study to Compare the Safety and Efficacy of Aliskiren 150mg, 300mg, and 600mg to Placebo in Patients With High Blood Pressure.
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: aliskiren
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: AnakInRa for Treatment of Recurrent Idiopathic Pericarditis (AIRTRIP)
Status: COMPLETED
Conditions: Idiopathic Recurrent Pericarditis
Interventions: DRUG: Anakinra|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Duration of Antibiotic Treatment in Community-acquired Pneumonia
Status: RECRUITING
Conditions: Community-acquired Pneumonia
Interventions: BEHAVIORAL: Reminders to the assistant clinicians of the need to adhere to clinical guidelines regarding the duration of antibiotic treatment community-acquired pneumonia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Impact of Tai Chi Combined With Music Therapy Intervention on Depression and Anxiety Among College Students
Status: COMPLETED
Conditions: Unrecognized Condition
Interventions: BEHAVIORAL: Tai Chi Combined with Music Therapy Intervention|BEHAVIORAL: Music intervention only|BEHAVIORAL: Tai Chi intervention only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: PD-1 Antibody Expressing CAR-T Cells for EGFR Family Member Positive Advanced Solid Tumor (Lung, Liver and Stomach)
Status: UNKNOWN
Conditions: PD-1 Antibody|CAR-T Cells|Advanced Solid Tumor
Interventions: BIOLOGICAL: HerinCAR-PD1 cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of an Antibiotic (Cefazolin) Before Surgery on the Microbiome in Patients With Stage I-II Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Clinical Stage I Cutaneous Melanoma AJCC v8|Clinical Stage IA Cutaneous Melanoma AJCC v8|Clinical Stage IB Cutaneous Melanoma AJCC v8|Clinical Stage II Cutaneous Melanoma AJCC v8|Clinical Stage IIA Cutaneous Melanoma AJCC v8|Clinical Stage IIB Cutaneous Melanoma AJCC v8|Clinical Stage IIC Cutaneous Melanoma AJCC v8|Pathologic Stage I Cutaneous Melanoma AJCC v8|Pathologic Stage IA Cutaneous Melanoma AJCC v8|Pathologic Stage IB Cutaneous Melanoma AJCC v8|Pathologic Stage II Cutaneous Melanoma AJCC v8|Pathologic Stage IIA Cutaneous Melanoma AJCC v8|Pathologic Stage IIB Cutaneous Melanoma AJCC v8|Pathologic Stage IIC Cutaneous Melanoma AJCC v8
Interventions: DRUG: Cefazolin|PROCEDURE: Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study That Evaluates the Decrease in Irritation When Using Additional Acne Treatment Products
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Dapsone plus Tretinoin Gel|DRUG: Tretinoin Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Review on Minimally Invasive Skin Incision in Vanguard PS Artificial Knee Joint System
Status: COMPLETED
Conditions: Gonarthrosis Patients Who Need Artificial Knee Joint Total Replacement
Interventions: PROCEDURE: Incision technique|PROCEDURE: Incision technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Evaluate the Safety and Effectiveness of Microneedling and Bellafill to Treat Facial Acne Scars
Status: COMPLETED
Conditions: Atrophic Acne Scars
Interventions: PROCEDURE: Microneedling|DEVICE: Microneedling followed by Bellafill treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Endemic and Emerging Diseases in Populations of Homeless Households in Marseille.
Status: COMPLETED
Conditions: Endemic and Emerging Diseases in Populations of Homeless
Interventions: OTHER: Swabs skin, pharyngeal, and blood sample|OTHER: Collection of body lice
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety Study of GSK Biologicals' DTPa-IPV/Hib (Infanrix™-IPV/Hib)
Status: COMPLETED
Conditions: Haemophilus Influenzae Type b|Acellular Pertussis|Diphtheria|Tetanus|Poliomyelitis
Interventions: BIOLOGICAL: Infanrix™-IPV/Hib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Open-label Extended Access Program on Lenalidomide Plus Dexamethasone in Chinese Subjects With Relapsed/Refractory Multiple Myeloma Who Participated in CC-5013-MM021 for at Least 1 Year
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Assessing Safety & Effectiveness of a Catheter Lock Solution in Dialysis Patients to Prevent Bloodstream Infection
Status: COMPLETED
Conditions: Kidney Failure, Chronic|Catheter-Related Infections
Interventions: DRUG: Neutrolin|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Everolimus (RAD001) in Patients of All Ages With Subependymal Giant Cell Astrocytoma Associated With Tuberous Sclerosis Complex (TSC)(EXIST-1)
Status: COMPLETED
Conditions: Tuberous Sclerosis|Subependymal Giant Cell Astrocytoma
Interventions: DRUG: Everolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subjective Memory Complaints, Objective Memory Performance and Cognitive Training
Status: COMPLETED
Conditions: Fatigue Syndrome, Chronic|Chronic Pain|Anxiety Disorders|Depressive Disorder|Sleep Disorders
Interventions: BEHAVIORAL: Cogmed working memory training|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parallel-Group Study to Assess the Effect of Rasagiline on Cognition in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Rasagiline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaginal Progesterone for the Prevention of Preterm Birth in Women With Arrested Preterm Labor
Status: TERMINATED
Conditions: Premature Birth|Obstetric Labor, Premature
Interventions: DRUG: Micronized progesterone suppository
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Evaluation of Tavilermide Ophthalmic Solution for the Treatment of Dry Eye
Status: COMPLETED
Conditions: Dry Eye Syndromes|Dry Eye Disease|Kerato Conjunctivitis Sicca
Interventions: DRUG: 5% Tavilermide ophthalmic solution|OTHER: Vehicle ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Salvianolic Acid on AIS
Status: TERMINATED
Conditions: Stroke
Interventions: DRUG: Salvianolic Acid|DRUG: 0.9% NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Pomalidomide, Bortezomib and Low-dose Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Pomalidomide|DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label, Single-Arm, Multicenter Pharmacokinetic Study of Intramuscular Erwinaze® (Asparaginase Erwinia Chrysanthemi)/Erwinase® (Crisantaspase)
Status: WITHDRAWN
Conditions: Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL)
Interventions: DRUG: Erwinaze® (Asparaginase Erwinia Chrysanthemi)/Erwinase® (Crisantaspase)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Desflurane and Brain Relaxation in Craniotomy
Status: COMPLETED
Conditions: Supratentorial Tumor
Interventions: DRUG: Desflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Implication of Cardiac Shock Wave Therapy on Coronary Artery Disease
Status: COMPLETED
Conditions: Cardiac Ischemia
Interventions: DEVICE: Cardiac shock wave therapy|OTHER: Sham cardiac shock wave (Control group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Genotype and Phenotype Guided Supplementation of TAMoxifen Standard Therapy With ENDOXifen in Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer|DCIS
Interventions: DRUG: (Z)-Endoxifen supplementation according to genotype|DRUG: (Z)-Endoxifen supplementation according to plasma levels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate a 25-Valent Pneumococcal Conjugate Vaccine
Status: COMPLETED
Conditions: Pneumococcal Vaccines
Interventions: BIOLOGICAL: IVT PCV-25|BIOLOGICAL: PCV 20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hematopoietic Stem Cell Transplantation for Mucopolysaccharidosis
Status: UNKNOWN
Conditions: Mucopolysaccharidosis
Interventions: DRUG: Conditioning regimen|DRUG: Graft-versus-host disease (GVHD) prophylaxis|PROCEDURE: Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Divalproex ER vs. Risperidone for Bipolar Disorder With Comorbid Substance Use Disorder
Status: COMPLETED
Conditions: Substance Abuse|Bipolar Depression
Interventions: DRUG: divalproex sodium ER|DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Prophylaxis of Post-ERCP Acute Pancreatitis
Status: RECRUITING
Conditions: Pancreatitis, Acute
Interventions: DRUG: Indomethacin suppository|COMBINATION_PRODUCT: Indomethacin suppository and high-flow lactated ringer infusion combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase II Study of the Pathophysiology and Treatment With Enalapril and Polystyrene Sulfonate for Pseudohypoaldosteronism, Type I
Status: COMPLETED
Conditions: Pseudohypoaldosteronism
Interventions: DRUG: enalapril|DRUG: polystyrene sulfonate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Anti-sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: DRUG: Stannous fluoride toothpaste|DRUG: Crest cavity protection toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy Planning Techniques in Reducing Damage to Normal Tissue in Women Undergoing Breast-Conserving Surgery for Ductal Carcinoma of the Breast
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: questionnaire administration|PROCEDURE: adjuvant therapy|PROCEDURE: biopsy|PROCEDURE: computed tomography|PROCEDURE: dynamic contrast-enhanced magnetic resonance imaging|PROCEDURE: magnetic resonance imaging|PROCEDURE: therapeutic conventional surgery|PROCEDURE: ultrasound imaging|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Using Tea-based Mouthwash Relieve Stomatitis and Oral Ulcers
Status: NOT_YET_RECRUITING
Conditions: Stomatitis
Interventions: COMBINATION_PRODUCT: mouthwash with tea
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Persistence and Long-Term Protection of Vi Antibodies Induced by Vi-DT Conjugate Vaccines in Indonesian
Status: ACTIVE_NOT_RECRUITING
Conditions: Vaccine
Interventions: DRUG: Vi-DT Typhoid Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Using Sodium Lactate Ringer's Injection Resuscitate Septic Shock Patients
Status: UNKNOWN
Conditions: Severe Sepsis With Septic Shock|Lactate
Interventions: DRUG: sodium lactate Ringer's injection(Baxter, ShangHai, China)|DRUG: Compound Sodium Chloride Injection (CR Double-Crane, Beijing, China)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate SCTA01 Treatment of High-risk Outpatients With COVID-19
Status: NOT_YET_RECRUITING
Conditions: COVID-19|SARS-CoV-2
Interventions: DRUG: SCTA01|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects
Status: NOT_YET_RECRUITING
Conditions: Familial Hypobetalipoproteinemia|Familial Hypobetalipoproteinemia - Heterozygous Form
Interventions: OTHER: Administration of deuterated compounds for kinetic study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy, Safety and Tolerability of Enteric-Coated Cholestyramine Capsules for Adult Short Bowel Syndrome
Status: TERMINATED
Conditions: Short Bowel Syndrome
Interventions: DRUG: Enteric-Coated Cholestyramine (ECC) Capsule|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of a Sore Throat Lozenge DORITHRICIN in Patients With Acute Pharyngitis
Status: COMPLETED
Conditions: Pharyngitis
Interventions: DRUG: Benzalkonium Chloride-Benzocaine Topical|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation and Evaluation of Tailored Interventions to Increase MMR and/or HPV Vaccine
Status: NOT_YET_RECRUITING
Conditions: Vaccination|Health Systems|Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: multicomponent intervention on vaccination awareness
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase 1b/2 Study of OMP-59R5 (Tarextumab) in Combination With Nab-Paclitaxel and Gemcitabine in Subjects With Previously Untreated Stage IV Pancreatic Cancer
Status: COMPLETED
Conditions: Stage IV Pancreatic Cancer
Interventions: DRUG: OMP-59R5|DRUG: Gemcitabine|DRUG: Placebo|DRUG: Nab-Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study for Long Term Evaluation of SAR153191 (REGN88) in Patients With Ankylosing Spondylitis
Status: TERMINATED
Conditions: Ankylosing Spondylitis
Interventions: DRUG: Sarilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Flow and Pressure Study of Craniospinal Dynamic
Status: ACTIVE_NOT_RECRUITING
Conditions: Intracranial Pressure|Cerebral Blood Flows|Infusion Test|Phase Contrast MRI|Hydrocephalus|Dementia
Interventions: OTHER: Flow MRI|OTHER: PERFUSION TEST
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: propofol|DRUG: Desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lidocaine Versus Bupivacaine in Orthognathic Surgery
Status: RECRUITING
Conditions: Pain, Postoperative|Numbness|Temperature Sensation|Perception of Touch
Interventions: DRUG: 10 cc of 0.25% bupivacaine hydrochloride with 1:200,000 epinephrine|DRUG: 6.8 cc of 2% lidocaine hydrochloride with 1:100,000 epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapies for Down Syndrome Regression Disorder
Status: RECRUITING
Conditions: Down Syndrome|Regression
Interventions: DRUG: Lorazepam|DRUG: Intravenous immunoglobulin (IVIG)|DRUG: Tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin-D Receptor Activation (VDRA) in Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Zemplar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Å6 in Ovarian Cancer Patients Following First-Line Chemotherapy and a Rising CA125 Levels
Status: COMPLETED
Conditions: Ovarian Cancer|Primary Peritoneal Carcinoma
Interventions: DRUG: Å6 subcutaneous injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Mobile Health Application to Improve HIV Medication Adherence
Status: COMPLETED
Conditions: HIV|Medication Adherence|Mobile Health
Interventions: BEHAVIORAL: Twine Collaborative Care Application|BEHAVIORAL: Information-Motivation-Behavioral Skills Model of ART Adherence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combining Placing a Synera Patch With Propofol/Lidocaine Mixture to Decrease Pain With IV Propofol Injection
Status: COMPLETED
Conditions: Pain on IV Injection of Propofol.
Interventions: DEVICE: Lidocaine/tetracaine transdermal patch|DRUG: Saline|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Developing Transcranial Neuromodulation Protocols for Learning and Decision-Making
Status: NOT_YET_RECRUITING
Conditions: Normal Physiology
Interventions: DEVICE: continuous Theta Burst Stimulation (cTBS)|DEVICE: intermittent Theta Burst Stimulation (iTBS)|DEVICE: sham Theta Burst Stimulation (sham TBS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Patterns of Treatment and Outcome of Palbociclib Plus Endocrine Therapy
Status: COMPLETED
Conditions: Breast|Neoplasm Malignant|Female
Interventions: DRUG: Palbociclib|DRUG: Letrozole 2.5mg|DRUG: Fulvestrant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy Study of Isolagen TherapyTM in the Treatment of Nasolabial Fold Wrinkles
Status: COMPLETED
Conditions: Bilateral Nasolabial Fold Wrinkles
Interventions: BIOLOGICAL: Autologous Human Fibroblast (azficel-T)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of a Non-Invasive Brainstem Neuromodulation Device to Improve Neurovascular Status in Parkinson's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: Non-invasive brainstem stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Anatomically Aligned Versus Conventional in Unilateral Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Knee Osteoarthritis|Anatomically Aligned Total Knee Arthroplasty
Interventions: DEVICE: Total knee arthroplasty implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development and Evaluation of a Home-Based Dual-Task Training Program to Improve Balance Performance for Older Adults
Status: COMPLETED
Conditions: Elderly|Aged
Interventions: OTHER: Balance exercise|OTHER: Cognitive training|OTHER: Dual-task cognitive-cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lipoic Acid for Progressive Multiple Sclerosis (MS)
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Lipoic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Apixaban in COVID-19 Coagulopathy Patients With Respiratory Severity Under Critical Care
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Apixaban|DRUG: Rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Quadriderme® in the Treatment of Impetiginous Eczema (Study P05134AM4)
Status: TERMINATED
Conditions: Dermatitis, Atopic|Eczema, Atopic|Skin Diseases, Eczematous
Interventions: DRUG: Cream (betamethasone diproprionate, clotrimazole, and gentamicin sulfate)|DRUG: Cream (betamethasone diproprionate and gentamicin)|DRUG: Cream (betamethasone diproprionate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Versus Laparoscopic Assisted Pancreaticoduodenectomy
Status: UNKNOWN
Conditions: Pancreas Neoplasm
Interventions: PROCEDURE: laparoscopic assisted pancreaticoduodenectomy|PROCEDURE: Open pancreaticduodenctomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial of a Botanical Drug Containing East Indian Sandalwood Oil (EISO) for the Treatment of Oral Mucositis
Status: COMPLETED
Conditions: Oral Mucositis
Interventions: DRUG: 0.25% EISO mouth rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment of Long-term Sequelae of Coronavirus Disease 2019 (COVID-19) Pneumonia With Chest CT and Pulmonary Function Tests
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19 Pneumonia|Sequelae of; Infection|Respiratory Function Impaired|SARS CoV 2 Infection|SARS-CoV 2 Pneumonia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Testing Adaptive Interventions to Improve Physical Activity for Sedentary Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Physical Activity
Interventions: BEHAVIORAL: Step 1: PA Monitor|BEHAVIORAL: Step 1: PA Monitor + Text|BEHAVIORAL: Step 2: PA Monitor with Calls|BEHAVIORAL: Step 2: PA Monitor with Meetings|BEHAVIORAL: Step 2: PA Monitor + Texts with Calls|BEHAVIORAL: Step 2: PA Monitor + Texts with Meetings|BEHAVIORAL: Step 3: PA Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Drug-drug Interaction Study With MDV3100 and a Cocktail of Substrates
Status: COMPLETED
Conditions: Pharmacokinetics of MDV3100|Castration Resistant Prostate Cancer (CRPC)
Interventions: DRUG: MDV3100|DRUG: Pioglitazone|DRUG: Warfarin|DRUG: Omeprazole|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Efficacy and Safety of (HCQ) as a Prophylaxis for COVID19 for Health Professionals
Status: WITHDRAWN
Conditions: COVID19|Sars-CoV2|Hydroxychloroquine|Prophylaxis|Healthcare Worker
Interventions: DRUG: Hydroxychloroquine (HCQ)|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Testing the Biological Effects of DS-8201a on Patients With Advanced Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|HER2-Positive Breast Carcinoma|Metastatic Malignant Solid Neoplasm|Refractory Malignant Solid Neoplasm|Unresectable Malignant Solid Neoplasm
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Echocardiography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Multigated Acquisition Scan|BIOLOGICAL: Trastuzumab Deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Magnetic Resonance (MR) Guided Focused Ultrasound in the Treatment of Large Fibroids
Status: COMPLETED
Conditions: Uterine Fibroids
Interventions: PROCEDURE: Magnetic Resonance Guided Focused Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Role of Information and Communication Technologies for Health Support in Inflammatory Bowel Diseases: The DAMASCO Trial
Status: UNKNOWN
Conditions: Inflammatory Bowel Diseases|Knowledge, Attitudes, Practice|Quality of Life|Treatment Adherence and Compliance
Interventions: OTHER: QUECOMIICAT survey|OTHER: Self-Efficacy for Appropriate Medication Use Scale|OTHER: ICTs preferences and barriers survey|OTHER: Focus group and IBD mobile App for health support (MAHS) development and validation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of SHR-1210 in Combination With BP102 in Subjects With Non-squamous NSCLC
Status: TERMINATED
Conditions: Lung Neoplasms
Interventions: DRUG: SHR-1210|DRUG: BP102
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of ES and MT VS ES and PNF Technique Among Bells Palsy Patients
Status: RECRUITING
Conditions: Bell Palsy
Interventions: DIAGNOSTIC_TEST: Mime Therapy|DIAGNOSTIC_TEST: PNF Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Recombinant Humanized Anti-TIGIT Monoclonal Antibody (JS006) Monotherapy and in Combination With Toripalimab in Patients With Advanced Tumor
Status: RECRUITING
Conditions: Advanced Tumors
Interventions: DRUG: JS006 as Monotherapy|DRUG: JS006 in combination with Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiopulmonary Circuits in the Pediatric Population
Status: COMPLETED
Conditions: Pediatric|Cardiac Surgery
Interventions: DEVICE: PC/SMART cardiopulmonary bypass circuit|DEVICE: PMEA modified cardiopulmonary bypass circuit|DEVICE: Standard of care uncoated cardiopulmonary bypass circuit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Chemotherapy With or Without Bevacizumab for Patients With Stage II or III Rectal Cancer
Status: TERMINATED
Conditions: Adenocarcinoma of the Rectum|Stage II Rectal Cancer|Stage III Rectal Cancer
Interventions: DRUG: oxaliplatin|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study of NE3107 in Probable Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: NE3107|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Add-on Montelukast to Inhaled Corticosteroids on Airway Responsiveness
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Montelukast (Singulair)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interest of Oral Corticosteroids in the Treatment of Chronic Subdural Hematomas
Status: TERMINATED
Conditions: Chronic Intracranial Subdural Hematoma
Interventions: DRUG: oral corticosteroids|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oxytocin as Adjunctive Treatment of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Oxytocin|DRUG: Placebo|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Gene by Medication Interaction to the Acute Effects of Alcohol
Status: TERMINATED
Conditions: Alcohol-induced Cue-craving|Alcohol Sensitivity
Interventions: DRUG: Placebo Comparator|DRUG: Active Comparator: Atomoxetine, Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cardiac Energetics and Function in Normal Human Ageing
Status: COMPLETED
Conditions: Left Ventricular Function Systolic Dysfunction|Left Ventricular Function Diastolic Dysfunction|Ageing
Interventions: DRUG: Ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study of Autologous Stem Cell Transplantation + Anti-CD19 CAR T Cells for B-cell Lymphoma
Status: RECRUITING
Conditions: B-cell Lymphoma
Interventions: BIOLOGICAL: ASCT+CAR-T Cell Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of SAGE-718 on Cognitive Function in Participants With Huntington's Disease (HD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Huntington's Disease
Interventions: DRUG: SAGE-718|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of Diagnosis and Treatment of Depression Based on Multidimensional Clinical Assessment Classification
Status: UNKNOWN
Conditions: Major Depressive Disorder
Interventions: DRUG: SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/ Serotonin and Norepinephrine Reuptake Inhibitors)|DRUG: Treatment as Usual|COMBINATION_PRODUCT: SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/ Serotonin and Norepinephrine Reuptake Inhibitors) Combined with Magnetic Stimulations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Sensimed Triggerfish (TF) 24 Hour Monitoring of the Eye in Glaucoma Patients Before and After Trabeculectomy
Status: COMPLETED
Conditions: Glaucoma
Interventions: DEVICE: Placement of Sensimed Triggerfish
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Atomoxetine on Psychosocial Function of Children and Adolescents With Attention-Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: atomoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Aleglitazar in Monotherapy in Patients With Type 2 Diabetes Mellitus Who Are Drug-Naïve to Anti-Hyperglycemic Therapy
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: aleglitazar|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dynamics of Platelet Activation in Patients With Ventricular Assist Device (VAD)
Status: RECRUITING
Conditions: Thrombosis|Blood Coagulation Disorder|Platelet Thrombus|Platelet Dysfunction Due to Aspirin|Failure;Ventricular
Interventions: DIAGNOSTIC_TEST: PAS assay, TGT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess the Safety and Tolerability of Ascending Single Doses of REGN2009 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: REGN2009|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Peripheral GABA Receptors for Local Pain Relief
Status: UNKNOWN
Conditions: Pain
Interventions: DRUG: GABA oral solution|DRUG: Intramuscular GABA|DRUG: Pain modulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial of Weekly Taxotere and Irinotecan (CPT-11) in Patients With Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Docetaxel|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety of Azilsartan Medoxomil and Chlorthalidone Compared to Olmesartan Medoxomil and Hydrochlorothiazide in Participants With Hypertension and Kidney Disease
Status: COMPLETED
Conditions: Safety
Interventions: DRUG: Azilsartan medoxomil and chlorthalidone|DRUG: Olmesartan medoxomil and hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Immunogenicity, Reactogenicity and Safety of Rotarix™ Vaccine in Korean Infants
Status: COMPLETED
Conditions: Infections, Rotavirus|Rotavirus Vaccines
Interventions: BIOLOGICAL: Rotarix ™|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Non-invasive Brain Stimulation and Occupational Therapy To Enhance Stroke Recovery
Status: COMPLETED
Conditions: Stroke|Cerebrovascular Accident|CVA|Acute Stroke|Acute Cerebrovascular Accident|Apoplexy
Interventions: DEVICE: Real Transcranial Direct Current Stimulation|DEVICE: Sham Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnosis and Staging of Neuroendocrine Tumors (NETs) Utilizing 68Ga-DOTATOC PET/CT Scan
Status: COMPLETED
Conditions: Neuroendocrine Tumors
Interventions: DRUG: 68Ga-DOTATOC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Retrospective and Prospective Real-world Study of Molecular Typing in the Treatment of Advanced Thyroid Cancer
Status: RECRUITING
Conditions: Advanced Thyroid Cancer Patients Who Received Target Therapy
Interventions: DRUG: dabrafenib plus trametinib with or without PD-1 antibody|DRUG: entrectinib or larotrectinib with or without anti-PD-1 antibdoy|DRUG: pralsetinib or selpercatinib with or without anti-PD-1 antibdoy|DRUG: anlotinib or anlotinib plus anti-PD-1 antibody|DRUG: lenvatinib plus anti-PD-1 antibody|DRUG: Other Targets: precise treatment based on the target
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Music Therapy for Spontaneous Breathing Trials
Status: TERMINATED
Conditions: Spontaneous Breathing Trial|Intubation|Mechanical Ventilation|Music Therapy
Interventions: OTHER: Music therapy plus standard care during an SBT|PROCEDURE: Standard care during an SBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ixazomib, Cyclophosphamide and Dexamethasone for Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Ixazomib|DRUG: Cyclophosphamide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sexual Counseling's Impact on Hip Replacement Patients' Sexual Function and Quality of Life: A PLISSIT Model Study
Status: NOT_YET_RECRUITING
Conditions: Hip Arthropathy|Sexual Function Disturbances|Quality of Life
Interventions: OTHER: sexual counseling based on the PLISSIT model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Safety and Tolerability Study of INCAGN02385 in Select Advanced Malignancies
Status: COMPLETED
Conditions: Cervical Cancer|Microsatellite Instability (MSI)-High Endometrial Cancer|Gastric Cancer (Including Stomach and Gastroesophageal Junction [GEJ])|Esophageal Cancer|Hepatocellular Carcinoma|Melanoma (Uveal Melanoma Excluded)|Merkel Cell Carcinoma|Mesothelioma|MSI-high Colorectal Cancer|Non-small Cell Lung Cancer (NSCLC)|Ovarian Cancer|Squamous Cell Carcinoma of the Head and Neck (SCCHN)|Small Cell Lung Cancer (SCLC)|Renal Cell Carcinoma (RCC)|Triple-negative Breast Cancer|Urothelial Carcinoma|Diffuse Large B-cell Lymphoma
Interventions: BIOLOGICAL: INCAGN02385
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy 3 vs 6 Gy in Gonarthrosis and Coxarthrosis
Status: UNKNOWN
Conditions: Gonarthrosis|Coxarthrosis
Interventions: RADIATION: Low dose radiotherapy A|RADIATION: Low dose radiotherapy B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sound Processing. ( A Feasibility, Prospective, Repeated-measures Investigation to Investigate Innovations in Sound Processing in Adult and Paediatric Recipients Implanted With CE Approved Nucleus Cochlear Implants: an Umbrella Investigation)
Status: COMPLETED
Conditions: Hearing Loss
Interventions: DEVICE: OPAL Sound Processing Strategy.|DEVICE: OPAL-EM|DEVICE: SPACE|DEVICE: FAST|DEVICE: OPAL-SPACE|DEVICE: FAST-OPAL|DEVICE: Cochlear Device Interface Tool
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Differential Gene Expression in Patients With Heart Failure and Iron Deficiency - Effects of Ferric Carboxymaltose
Status: TERMINATED
Conditions: Heart Failure
Interventions: DRUG: ferric carboxymaltose|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Can Hypothermia be Incorporated Into Primary Angioplasty for Heart Attack?
Status: NOT_YET_RECRUITING
Conditions: ST-Elevation Myocardial Infarction
Interventions: DEVICE: Life Recovery Systems ThermoSuit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Copper 64Cu-DOTA-Daratumumab Positron Emission Tomography in Diagnosing Patients With Relapsed Multiple Myeloma
Status: COMPLETED
Conditions: Recurrent Plasma Cell Myeloma|Plasma Cell Myeloma|Secondary Amyloidosis
Interventions: BIOLOGICAL: Daratumumab|DRUG: Imaging Agent|PROCEDURE: Positron Emission Tomography|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of 1 Versus 2 Days Post-Operative Catheterization After Anterior Colporrhaphy
Status: RECRUITING
Conditions: Catheter Related Complication|Anterior Vaginal Wall Prolapse
Interventions: PROCEDURE: Catheter removal after surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Ciforadenant in Combination With Daratumumab in Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Ciforadenant|DRUG: daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Combination Antifungal Therapy (Vori+Mica vs. Vori+Placebo) in Invasive Aspergillosis
Status: WITHDRAWN
Conditions: Aspergillosis
Interventions: DRUG: Voriconazole, micafungin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tapering Off Antidepressants
Status: TERMINATED
Conditions: Major Depressive Disorder|Anxiety Disorder|Obsessive Compulsive Disorder|Post-Traumatic Stress Disorder
Interventions: OTHER: Two-Week Antidepressant Taper Regimen|OTHER: One-Week Antidepressant Taper Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Routine Postoperative Oxygen Therapy Still Necessary in 2020?
Status: COMPLETED
Conditions: Postoperative Oxygen Therapy
Interventions: PROCEDURE: automated oxygenation with a sitting patient position in the ICU|PROCEDURE: Automated oxygenation with the patient lying down in the ICU|PROCEDURE: Oxygenation is controlled with the patient in a sitting position in the ICU.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Investigate the Efficacy and Safety of ONO-4578 in Combination With Nivolumab and Chemotherapy in Chemotherapy-naïve Participants With HER2-negative Unresectable Advanced or Recurrent Gastric Cancer (Including Esophagogastric Junction Cancer)
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: ONO-4578|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: S-1|DRUG: Nivolumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Magnesium Supplementation in Athletes With Premature Ventricular Contractions or Premature Atrial Contractions.
Status: UNKNOWN
Conditions: Ventricular Premature Complexes|Atrial Premature Complexes
Interventions: DIETARY_SUPPLEMENT: Magnesium glycinate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Photobiomodulation and Deep Water Running Training in Subjects With Low Back Pain.
Status: COMPLETED
Conditions: Low Back Pain|Hydrotherapy|Exertion; Excess
Interventions: DEVICE: Training and LED group|DEVICE: Training group|OTHER: LED group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE