pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Efficacy of Secukinumab in Mild Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Secukinumab|DRUG: Placebo followed by Secukinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proseal Laryngeal Mask Airway or Endotracheal Tube for Emergence From Neuroanesthesia
Status: COMPLETED
Conditions: Hypertension on Emergence
Interventions: PROCEDURE: Endotracheal tube|PROCEDURE: LMA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Terlipressin Versus Placebo to Treat Hepatorenal Syndrome Type 1
Status: COMPLETED
Conditions: Hepatorenal Syndrome
Interventions: DRUG: terlipressin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Advanced Chronic Liver Disease Screening by Transient Elstography in Patients Hospitalised in a Psychiatric Unit
Status: COMPLETED
Conditions: Psychiatric Disorder|Psychiatric Hospitalization|Advanced Chronic Liver Disease|Liver Fibrosis
Interventions: DIAGNOSTIC_TEST: non invasive evaluation of liver fibrosis by transient elastography (Fibroscan ®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Entospletinib in Combination With Idelalisib in Adults With Relapsed or Refractory Hematologic Malignancies
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia|Mantle Cell Lymphoma|Diffuse Large B-cell Lymphoma|Indolent Non-Hodgkin's Lymphoma
Interventions: DRUG: Entospletinib|DRUG: Idelalisib
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hormonal and Inflammatory Biomarkers and Response to Cognitive Remediation in Recent-onset Psychosis
Status: COMPLETED
Conditions: Psychotic Disorders
Interventions: BEHAVIORAL: cognitive remediation|OTHER: attendance to an Early Intervention Service for Psychosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Postoperative Chemoradiation v.s Radiotherapy for Lymph Node Negative Cervical Cancer Patients
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: DRUG: paclitaxel|DRUG: cisplatin|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Therapeutic Amplitude-modulated Electromagnetic Fields in Advanced Tumors
Status: COMPLETED
Conditions: Cancer|Brain Tumor
Interventions: DEVICE: Low levels of amplitude-modulated electromagnetic fields|DEVICE: Emitter of low levels of amplitude-modulated electromagnetic fields
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Teneligliptin and Atorvastatin DDI Study
Status: COMPLETED
Conditions: Diabete Mellitus
Interventions: DRUG: Teneligliptin 20mg/day|DRUG: Atorvastatin 40mg/Day|DRUG: Teneligliptin 20mg/day + Atorvastatin 40mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Mature Dendritic Cell Vaccination Against Unique Immunogenic Peptides in Patients With Non Small Cell Lung Cancer (NSCLC)
Status: WITHDRAWN
Conditions: Carcinoma, Non-Small-Cell-Lung|Non-Small Cell Lung Cancer|Nonsmall Cell Lung Cancer
Interventions: PROCEDURE: Standard of care surgery|PROCEDURE: Apheresis|DRUG: Cyclophosphamide|BIOLOGICAL: Personalized mature dendritic cell vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficiency of the King Vision Video Laryngoscope
Status: COMPLETED
Conditions: Respiratory Failure|Intubation
Interventions: DEVICE: Macintosh laryngoscope|DEVICE: King Vision video laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Application of Electrical Neurostimulation Transcutaneous in Patients With Primary Dysmenorrhea.
Status: COMPLETED
Conditions: Primary Dysmenorrhea
Interventions: DEVICE: TENS|DEVICE: TENS (sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physician-Sponsored IDE for the Talent Endoluminal Stent Graft System for the Treatment of Thoracic Lesions
Status: COMPLETED
Conditions: Thoracic Aortic Aneurysms|Thoracic Transections|Intramural Hematoma|Pseudoaneurysm|Thoracic Aortic Dissection
Interventions: DEVICE: Endoluminal treament of thoracic lesions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Intravesical Cocktail With Intravesical Dimethyl Sulfoxide (DMSO) in Painful Bladder Syndrome/Interstitial Cystitis (PBS/IC)
Status: TERMINATED
Conditions: Interstitial Cystitis|Bladder Diseases
Interventions: DRUG: dimethyl sulfoxide|DRUG: IC Cocktail
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Reactogenicity of a H1N1 Influenza Challenge Virus in Healthy Volunteers
Status: COMPLETED
Conditions: Influenza A
Interventions: OTHER: 1:1000 Live wild-type A/California/H1N1 2009|OTHER: 1:100 Live wild-type A/California/H1N1 2009|OTHER: 1:10 Live wild-type A/California/H1N1 2009
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Digital Foot Self-Management Program for Older-Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus|Type 2 Diabetes|Glucose Metabolism Disorders|Endocrine System Diseases|Metabolic Diseases
Interventions: BEHAVIORAL: A digital foot self-management program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: SODium BICarbonate for Metabolic Acidosis in the ICU
Status: RECRUITING
Conditions: Metabolic Acidosis|Shock
Interventions: DRUG: Sodium bicarbonate|DRUG: 5% Dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioural Therapy for Avoidant/Restrictive Food Intake Disorder (CBT-AR)
Status: RECRUITING
Conditions: Avoidant/Restrictive Food Intake Disorder (ARFID)
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy for Avoidant/Restrictive Food Intake Disorder (CBT-AR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eribulin Versus Vinorelbine in Subjects With Locally Recurrent or Metastatic Breast Cancer Previously Treated With Anthracyclines and Taxanes
Status: COMPLETED
Conditions: HER2-Negative Breast Cancer|Triple Negative Breast Cancer|Breast Cancer|Cancer of Breast|Breast Tumors
Interventions: DRUG: E7389 (Eribulin Mesylate)|DRUG: Vinorelbine injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Blood Pressure Control in Acute Aortic Emergencies - A Pilot Study (PROMPT)
Status: TERMINATED
Conditions: Aortic Aneurysm|Aortic Disease
Interventions: DRUG: clevidipine.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monitoring of Weight Bearing Protocols Via Mobile Application and Pressure Sensors.
Status: COMPLETED
Conditions: Osteochondral Lesion of Talus
Interventions: DEVICE: With WBM smart insole system to monitor compliance of specified weight bearing limits data in live feedback on and off situations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Combination Drug Therapy Followed by Single Drug Steroid Free Therapy to Prevent Organ Rejection in Kidney Transplantation
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: Sirolimus|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Second Study of Cytisinicline for Smoking Cessation in Adult Smokers
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Cytisinicline|DRUG: Placebo|BEHAVIORAL: Behavioral support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy and Sargramostim in Treating Patients With Malignant Glioma
Status: COMPLETED
Conditions: Anaplastic Astrocytoma|Anaplastic Oligoastrocytoma|Anaplastic Oligodendroglioma|Giant Cell Glioblastoma|Glioblastoma|Gliosarcoma|Mixed Glioma|Recurrent Brain Neoplasm
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Montanide ISA-51/Survivin Peptide Vaccine|BIOLOGICAL: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Edasalonexent With Midazolam and Deflazacort in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Edasalonexent 2000 mg TID|DRUG: Midazolam 2 MG/ML|DRUG: Deflazacort 36Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Ocular Surface Disease and IOP Monitoring With Travoprost Without Conservatives
Status: COMPLETED
Conditions: Glaucoma|Glaucoma; Drugs|Ocular Surface Disease
Interventions: DIAGNOSTIC_TEST: Intraocular pressure (IOP)|DIAGNOSTIC_TEST: Tear Break-up Time (TBUT)|DIAGNOSTIC_TEST: Conjuctival Hyperemia|DIAGNOSTIC_TEST: Schirmer Test|DIAGNOSTIC_TEST: Visual Fields and OCT RNFL
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Gastroduodenal Metallic Stent vs Gastrojejunostomy
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DEVICE: gastroduodenal stent placement|PROCEDURE: gastrojejunostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperoxia Induced Pulmonary Inflammation and Organ Injury: a Human in Vivo Model
Status: RECRUITING
Conditions: Oxygen Toxicity|Pulmonary Injury|Acute Lung Injury
Interventions: DRUG: Liquid oxygen|DRUG: medical air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluating the Effectiveness of Various Iron Salts and Carrier Systems in Oral Iron Therapy for Iron Deficiency and Anemia in Healthy Adults
Status: RECRUITING
Conditions: Iron Deficiency|Iron Deficiency Anemia
Interventions: DIETARY_SUPPLEMENT: Oral Ferric pyrophosphate|DIETARY_SUPPLEMENT: Oral Sodium ferric pyrophosphate|DIETARY_SUPPLEMENT: Oral Ferric maltose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Voice as a Tool to Detect Recurrence of Laryngeal and Hypopharyngeal Cancer
Status: RECRUITING
Conditions: Laryngeal Cancer|Hypopharyngeal Cancer
Interventions: OTHER: Voice recording, ENT (Ear, Nose and Throat) examination including transnasal fiberendoscopy, and VHI-30-questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Short Versus Long Intramedullary Nails in the Treatment of Proximal Femur Metastasis.
Status: NOT_YET_RECRUITING
Conditions: Bone Metastases|Pathological Fracture|Pathological Fracture, Left Femur|Pathological Fracture, Right Femur
Interventions: DEVICE: Internal fixation with short intramedullary nails|DEVICE: Internal fixation with long intramedullary nails
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Elranatamab (PF-06863135) in Chinese Participants With Refractory Multiple Myeloma.
Status: ACTIVE_NOT_RECRUITING
Conditions: Elranatamab|Myeloma|Multiple Myeloma|Relapsed Multiple Myeloma|Refractory Multiple Myeloma|PF-06863135|BCMA|Bispecific|Bispecific Antibody|BCMA-CD3 Bispecific|MagnetisMM-8
Interventions: DRUG: Elranatamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intermittent Oro-esophageal Tube Feeding on Severe Traumatic Brain Injury Patients With Tracheostomy
Status: TERMINATED
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: Rehabilitation therapy|DEVICE: Intermittent Oro-esophageal Tube Feeding|DEVICE: Nasogastric tube feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2B Study to Evaluate the Efficacy of Bentracimab (PB2452) in Reversal of Ticagrelor in Subjects Aged 50-80 Years Old
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ticagrelor Oral Tablet - Pre-Treatment|DRUG: Aspirin (ASA) Oral Tablet - Pre-Treatment|DRUG: Bentracimab (PB2452) Infusion|DRUG: Placebo (0.9% Sodium chloride) infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Pharmacokinetics, Safety & Tolerability of 101-PGC-005 in Healthy, Adult, Human Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Glucocorticoids Toxicity|COVID-19|Infectious Disease|Virus Diseases
Interventions: DRUG: 101-PGC-005
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trail to Evaluate the Efficacy and Safety of Adhesion Barrier Mediclore Versus no Treatment in Patients With Total Thyroidectomy
Status: UNKNOWN
Conditions: Patients With Thyroidecomy (Scheduled)
Interventions: DEVICE: Mediclore
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Measurements of Corneal Biomechanical Properties Using a Dynamic Scheimpflug Analyzer for Normal Adults in South Korea
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: dynamic Scheimpflug analyzer (corneal visualization Scheimpflug technology [Corvis ST], OCULUS, Wetzlar, Germany)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Blade Finger Technique for Safe Laparoscopic Entery
Status: COMPLETED
Conditions: Laparoscopic Surgery|Operative Surgical Procedure|Insufflation|Safety Issues
Interventions: PROCEDURE: finger-blade technique|PROCEDURE: Hasson's technique|PROCEDURE: veress needle technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Deep Neck Flexors Biofeedback Training and Post Isometric Relaxation in Chronic Mechanical Neck Pain
Status: NOT_YET_RECRUITING
Conditions: Deep Neck Flexors Training|Post Isometric Relaxation
Interventions: DEVICE: pressure biofeedback|DEVICE: therapeutic ultra sound|DEVICE: infra red radiation|OTHER: post isometric relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Clinical Trial of the Safety and Effects of IRX-2 in Treating Patients With Operable Head and Neck Cancer
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: BIOLOGICAL: IRX-2|DRUG: Cyclophosphamide|DRUG: Indomethacin|DRUG: Zinc|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety of Experimental Medication BMS986165 in Participants With Normal Kidney Function and Participants With Mild to End-Stage Kidney Disease.
Status: COMPLETED
Conditions: Renal Impairment|Healthy Volunteer
Interventions: DRUG: BMS-986165
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Cardiovascular Risk in Adults With Serious Mental Illness
Status: COMPLETED
Conditions: Chronic Disease|Mental Disorder|Health Behavior|Bipolar Disorder|Schizophrenia
Interventions: BEHAVIORAL: Prioritized Clinical Decision Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Protection of Intravenous Dexmedetomidine During Radical Cystectomy
Status: COMPLETED
Conditions: Radical Cystectomy
Interventions: DRUG: Dexmedetomidine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rezum I Pilot Study for Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Prostatic Hyperplasia|Benign Prostatic Hyperplasia|Adenoma, Prostatic|Prostatic Adenoma|Prostatic Hyperplasia, Benign|Prostatic Hypertrophy|Prostatic Hypertrophy, Benign|Rezum
Interventions: DEVICE: Rezum System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficiency of Intra-uterine Insemination and in Vitro Fertilization in Women Over 37 Years
Status: TERMINATED
Conditions: Infertilities
Interventions: PROCEDURE: In Vitro Fecundation (IVF)|PROCEDURE: Intra Uterine Insemination (IUI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Safety and Tolerability of RXC004 in Advanced Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer|Solid Tumor
Interventions: DRUG: RXC004|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RGX-121 Gene Therapy in Children 5 Years of Age and Over With MPS II (Hunter Syndrome)
Status: ACTIVE_NOT_RECRUITING
Conditions: Mucopolysaccharidosis Type II (MPS II)
Interventions: GENETIC: RGX-121
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Triggers and Risk Factors for Recurrence of Atrial Arrhythmias With the Use of Long-term Monitoring
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation|Atrial Flutter|Atrial Arrhythmia|Atrial Tachycardia|Premature Atrial Contractions|Arterial Hypertension|Sleep Disorder|Sleep Apnea|Stress|Physical Inactivity|Overexertion|Alcohol Drinking|Caffeine Dependence
Interventions: DEVICE: Devices for long-term monitoring of objective and subjective parameters of the body
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess Efficacy and Safety of Inecalcitol in Imatinib-Treated Residual Chronic Myeloid Leukaemia: INIM Study
Status: UNKNOWN
Conditions: CML, Chronic Phase
Interventions: DRUG: Inecalcitol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Trial of ACZONE (Dapsone) Gel, 7.5% in 9 to 11 Year-Old Patients With Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: dapsone gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Liposomal Amphotericin B for Histoplasmosis in AIDS Patients
Status: COMPLETED
Conditions: Histoplasmosis|AIDS
Interventions: DRUG: single dose of L-AmB|DRUG: 2 doses of L-AmB|DRUG: 2 weeks of L-AmB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sugammadex Dosed According to Actual Body Weight (ABW) or Ideal Body Weight (IBW) in Reversal of Neuromuscular Blockade (NMB) in Morbidly Obese Participants (MK-8616-146)
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: DRUG: Sugammadex 2 mg/kg ABW|DRUG: Sugammadex 2 mg/kg IBW|DRUG: Sugammadex 4 mg/kg ABW|DRUG: Sugammadex 4 mg/kg IBW|DRUG: Neostigmine + Glycopyrrolate|DRUG: Rocuronium or Vecuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery
Status: UNKNOWN
Conditions: Aortic Valve Insufficiency|Aortic Valve Stenosis|Mitral Valve Insufficiency|Mitral Valve Stenosis|Acute Coronary Syndrome
Interventions: DRUG: antithrombin III
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Temporal Dynamics and Pharmacokinetics of Intranasally Administered Oxytocin
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Technology for Innovative Monitoring of Cardiovascular Prevention: a RCT
Status: UNKNOWN
Conditions: Blood Pressure, High|Prehypertension
Interventions: DEVICE: TELEM|DEVICE: TELEMEV|DEVICE: TELEM-TELEMEV|OTHER: UCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Reinforcing Standard Therapy in COVID-19 Patients With Repeated Transfusion of Convalescent Plasma
Status: COMPLETED
Conditions: Covid19
Interventions: OTHER: Convalescent Plasma with antibody against SARS-CoV-2.|OTHER: Standard treatment for COVID-19
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Mild and Moderate Hepatic Impairment on the Safety and Tolerability of Fezolinetant Compared to Participants With Normal Hepatic Function
Status: COMPLETED
Conditions: Hepatic Impairment|Healthy Volunteers
Interventions: DRUG: fezolinetant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective, Multi-Center, Observational, Whole Blood Specimen Collection Study in Participants With Rheumatoid Arthritis With Inadequate Response or Intolerance to a DMARD Starting a New bDMARD or tsDMARD Treatment +/- csDMARD
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Face-to-face Tracheal Intubation: a Comparison of Airtraq, Glidescope and Fastrach
Status: COMPLETED
Conditions: Intubation Difficult
Interventions: DEVICE: Glidescope|DEVICE: Airtraq|DEVICE: Fastrach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Instrument Assisted Soft Tissue Mobilization and Stretching Exercises in Cerebral Palsy
Status: UNKNOWN
Conditions: Cerebral Palsy
Interventions: OTHER: Instrument Assisted Soft Tissue Mobilization|OTHER: Stretching Exercises|OTHER: Control Group / NDT program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Fluoxetine Against Seizure-induced Central Apneas
Status: COMPLETED
Conditions: Epilepsy|Ictal/Post-ictal Hypoxemia
Interventions: DRUG: fluoxetine 20 mg|DRUG: placebo 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chances in Portal System Flow After Two Bariatric Procedures
Status: UNKNOWN
Conditions: Portal Vein Thrombosis
Interventions: PROCEDURE: Laparoscopic sleeve gastrectomy|PROCEDURE: Laparoscopic mini gastric bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Does Prophylactic Coronary Artery Revascularization for High Risk Patients Reduce Long-term Risk of Mortality
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: PROCEDURE: Vascular surgery with best medical treatment|PROCEDURE: Coronary artery bypass grafting (CABG)|PROCEDURE: Percutaneous transluminal coronary angioplasty (PTCA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Caffeine on Acupuncture Analgesia With the Human Pain Model
Status: COMPLETED
Conditions: Pain
Interventions: DEVICE: acupuncture|DIETARY_SUPPLEMENT: 200mg caffeine|DIETARY_SUPPLEMENT: 400mg caffeine|DIETARY_SUPPLEMENT: Decaffeinated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Peritonsillar Dexmedetomidine Infiltration for Postadenotonsillectomy Pain
Status: COMPLETED
Conditions: Pain Postoperative, Intraoperative Hemorrhage
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopy and Radiology-guided Ablation for Inoperable Cholangiocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Perihilar Cholangiocarcinoma
Interventions: PROCEDURE: Endoluminal radiofrequency ablation|PROCEDURE: Endoscopic biliary stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Assessment of Lactobacillus Fermented Extract in Cancer Patients Undergoing Chemotherapy
Status: WITHDRAWN
Conditions: Cancer
Interventions: DIETARY_SUPPLEMENT: Seigen Alpha EV|DIETARY_SUPPLEMENT: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Photo-Protection Trial (NB-UVB vs. Placebo) in High-risk Hospitalized COVID-19 Patients
Status: COMPLETED
Conditions: Covid19|Corona Virus Infection|Autoimmune Diseases|Coagulation Disorder, Blood
Interventions: DEVICE: Narrow Band ultraviolet B-Band Light|DEVICE: non Narrow Band ultraviolet B-Band Light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Dose Chemotherapy With Amifostine and Autologous Stem Cell Transplantation for High Risk Relapsed Pediatric Solid Tumors and Brain Tumors
Status: TERMINATED
Conditions: Solid Tumors|Brain Tumors
Interventions: DRUG: Amifostine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Whole-Body 3D T1-weighted MR Imaging Anatomical Sequences: GE mDixon vs FSE (View) Approaches in Prostate Cancer.
Status: COMPLETED
Conditions: Prostate Adenocarcinoma|Metastasis
Interventions: DIAGNOSTIC_TEST: Diagnostic performance 3D T1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: LMB-9 Immunotoxin in Treating Patients With Advanced Pancreatic, Esophageal, Stomach, Colon, or Rectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer|Esophageal Cancer|Gastric Cancer|Pancreatic Cancer
Interventions: BIOLOGICAL: LMB-9 immunotoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effect of Eszopiclone on the Arousal Threshold in Sleep Apnea Syndrome
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: Eszopiclone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy Study of Antioxidants for the Treatment of the Fragile X Syndrome
Status: COMPLETED
Conditions: Fragile X Syndrome
Interventions: DIETARY_SUPPLEMENT: Ascorbic Acid (Vitamin C) and Alpha-tocopherol (Vitamin E)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Trehalose and Polyphenols in Vasculopathic Patients
Status: COMPLETED
Conditions: Oxidative Stress|Cardiovascular Diseases
Interventions: OTHER: Supplementation with mix of threalose plus polyphenols|OTHER: No Supplementation with mix of threalose plus polyphenols
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Fispemifene in the Treatment of Hypogonadal Men With Chronic Obstructive Pulmonary Disease That Are on Oral Glucocorticoid Therapy
Status: COMPLETED
Conditions: Hypogonadism|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Fispemifene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Brentuximab Vedotin (SGN-35) in Patients With Mycosis Fungoides With Variable CD30 Expression Level
Status: COMPLETED
Conditions: Non-Hodgkin Lymphoma (NHL)|Cutaneous Lymphoma|Cutaneous T-cell Lymphoma (CTCL)|Mycosis Fungoides|Sezary Syndrome
Interventions: DRUG: Brentuximab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 2-year Treatment Outcomes of Teeth Estimated by Means of Periapical and Endodontic Status Scale
Status: COMPLETED
Conditions: Periapical Periodontitis|Treatment Outcome
Interventions: DIAGNOSTIC_TEST: Analysis of treatment outcomes of teeth with apical periodontitis based on cone-beam computed tomography and estimated by means of Periapical and Endodontic Status Scale"
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal
Status: COMPLETED
Conditions: Penicillin Allergy
Interventions: OTHER: Penicillin Allergic Risk Stratification Best Practice Alert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Reparixin for Early Allograft Dysfunction Prevention in Liver Transplantation
Status: COMPLETED
Conditions: Ischemia-reperfusion Injury in Liver Transplant|Early Allograft Dysfunction
Interventions: DRUG: Reparixin|OTHER: Standard care procedures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Dose Study to Evaluate Security, Tolerance and Pharmacokinetic of Fexinidazole (Drug Candidate for Human African Trypanosomiasis) Administered With a Loading Dose and With Food
Status: TERMINATED
Conditions: Trypanosomiasis, African
Interventions: DRUG: Tablets Fexinidazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab Versus Ranibizumab for Diabetic Retinopathy
Status: COMPLETED
Conditions: Diabetic Retinopathy|Diabetic Macular Edema|Proliferative Diabetic Retinopathy
Interventions: DRUG: bevacizumab|DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Endothelin-1 in Optic Nerve Head Blood Flow Regulation During Isometric Exercise in Healthy Humans
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BQ-123|DRUG: Physiological saline solution|DEVICE: Laser Doppler Flowmetry|DEVICE: Goldmann Applanation Tonometer|OTHER: squatting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pivotal Study to Assess the Safety and Efficacy of The PrePex System, a Male Circumcision Device and Methodology for Rapid Scale up of Painless and Bloodless National Circumcision Programs, in Urban and Remote Rural Settings
Status: COMPLETED
Conditions: Male Circumcision|HIV Prevention|HIV Infections
Interventions: DEVICE: The PrePex a novel device for adult male circumcision
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparative Bioavailability of BAFIERTAM™ (Monomethyl Fumarate) and Tecfidera® (Dimethyl Fumarate) in Healthy Subjects
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: monomethyl fumarate 190 mg|DRUG: dimethyl fumarate 240 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Retrospective Chart Review Study of Patients With Chronic Lung Allograft Dysfunction-Bronchiolitis Obliterans Syndrome (CLAD-BOS) Post Lung Transplantation
Status: RECRUITING
Conditions: Bronchiolitis Obliterans Syndrome Due to and After Lung Transplantation (Disorder)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot-testing the Effect of Magnetic Mitohormesis Therapy for Treating Frailty in Older Adults
Status: RECRUITING
Conditions: Frailty
Interventions: OTHER: Magnetic Mitohormesis Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Letrozole With or Without Zoledronate in Treating Healthy Postmenopausal Women With High Breast Density
Status: COMPLETED
Conditions: Breast Cancer|Osteoporosis
Interventions: DRUG: letrozole|DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Hormone Therapy With Arzoxifene Hydrochloride in Treating Women With Metastatic Refractory Ovarian Cancer or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: arzoxifene hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: S 48168 (ARM 210) for the Treatment of RYR1-related Myopathies (RYR1-RM)
Status: COMPLETED
Conditions: RYR-1 Myopathy
Interventions: DRUG: S48168
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Window of Opportunity Study to Assess the Modulation of Biomarkers in Head and Neck Squamous Cell Cancer (HNSCC) By Preoperative Treatment With BYL719
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Squamous Cell Cancer
Interventions: DRUG: BYL719
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Ranging Study of Brentuximab Vedotin in Adults With Lupus
Status: TERMINATED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Brentuximab vedotin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Automated Screening for Clinically Ascertained Loss of Cerebral Functions
Status: NOT_YET_RECRUITING
Conditions: Irreversible Loss of Brain Function (ILBF)
Interventions: OTHER: DETECT|OTHER: Conventional care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Lower Leg Edema Evaluation After Total Knee Arthroplasty Using Bioimpedance
Status: COMPLETED
Conditions: Edema
Interventions: DEVICE: bioimpedance spectroscopy ImpediMed SFB7 Brisbane Australia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison Between Tamsulosin and Tadalafil in Management of Benign Prostatic Hyperplasia Long Term Study
Status: COMPLETED
Conditions: BPH
Interventions: DRUG: Tamsulosin|DRUG: Tadalafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bovine Lactoferrin as a Natural Regimen of Selective Decontamination of the Digestive Tract in Patients With Prolonged Mechanical Ventilation
Status: UNKNOWN
Conditions: Nosocomial Infections
Interventions: DIETARY_SUPPLEMENT: bovine Lactoferrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Immune Modulatory Drugs and Other Treatments in COVID-19 Patients: Sarilumab, Azithromycin, Hydroxychloroquine Trial - CORIMUNO-19 - VIRO
Status: SUSPENDED
Conditions: COVID19|SARS-CoV-2 Infection
Interventions: DRUG: Sarilumab|DRUG: Azithromycin|DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of SNAGs on Stiffness of Lumbar Stabilizer Muscles
Status: COMPLETED
Conditions: Low Back Pain|Manuel Therapy
Interventions: OTHER: Real Sustained Natural Apophyseal Glides (SNAGS)|OTHER: Sham Sustained Natural Apophyseal Glides (SNAGS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Telehealth Autism Assessment for Adults
Status: WITHDRAWN
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: ADOS-2 Module 4|BEHAVIORAL: Adapted Telehealth ADOS-2 Module 4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: PaTHway CHINA TRIAL: A Trial to Investigating the Safety, Tolerability and Efficacy of TransCon PTH in Adults With Hypoparathyroidism
Status: RECRUITING
Conditions: Hypoparathyroidism|Parathyroid Hormone Deficiency|Endocrine System Diseases|Parathyroid Diseases
Interventions: DRUG: TransCon PTH|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study to Evaluate Denosumab Compared With Zoledronic Acid in Postmenopausal Women With Osteoporosis
Status: COMPLETED
Conditions: Post Menopausal Osteoporosis
Interventions: BIOLOGICAL: Denosumab|DRUG: Zoledronic Acid|DRUG: Placebo to Denosumab|DRUG: Placebo to Zoledronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Jaw Exercise Program in Temporomandibular Disorders Patients
Status: UNKNOWN
Conditions: Temporomandibular Joint Disorders|Musculoskeletal Diseases
Interventions: PROCEDURE: Jaw exercise program|DEVICE: Occlusal Splint and counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Intravitreal Autologous Platelet Concentrate Injection as an Adjunct of Vitrectomy for the Treatment of Refractory Macular Holes
Status: UNKNOWN
Conditions: Macular Hole With High Myopia (Spherical Equivalent ≤ -6.0 Diopters) or,|Large Size Macular Hole (Diameter > 600 Microns) or|Recurred or Failed Macular Hole From Previous Surgery|or Chronic Macular Hole (Symptom Duration > 6 Months)
Interventions: PROCEDURE: Autologous platelet concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychotherapy of Anxiety Disorders With Noninvasive Brain Stimulation - Using Virtual Reality
Status: COMPLETED
Conditions: Phobia
Interventions: DEVICE: Verum TMS|DEVICE: Sham TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stellate Ganglion to Prevent Atrial Fibrillation
Status: WITHDRAWN
Conditions: Atrial Fibrillation New Onset
Interventions: PROCEDURE: Stellate ganglion block|DRUG: Bupivacain|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Intravenous Co-amoxiclav Versus Benzyl Penicillin
Status: COMPLETED
Conditions: Tonsillitis Streptococcal
Interventions: DRUG: inj co-amoxiclav 50 units/kg/day vs inj Benzyl Penicillin 25000 units/kg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Clinical Efficacy of Rezūm Therapy Versus Bipolar Trans-urethral Resection of the Prostate for Treatment Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Prostatic Hyperplasia
Interventions: PROCEDURE: Rezum procedure|PROCEDURE: B-TURP procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Shock Wave Therapy in the Treatment of Primary Dysmenorrhea
Status: COMPLETED
Conditions: Dysmenorrhea Primary|Pain, Menstrual
Interventions: OTHER: extracorporeal shock wave therapy|OTHER: hot compress paste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Pharmacokinetic Study of NBM-BMX Administered Orally to Asian Patients With Advanced Cancer
Status: COMPLETED
Conditions: Malignant Neoplasm
Interventions: DRUG: NBM-BMX softgel capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Treatment With Nivolumab Alone and Nivolumab Combined With Ipilimumab in Children With Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Nivolumab +/- ipilimumab|DRUG: Nivolumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neo-adjuvant Erbitux-based Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer
Status: COMPLETED
Conditions: Locally Advanced Malignant Neoplasm|Oral Cancer|Oropharyngeal Carcinoma
Interventions: DRUG: Neo-adjuvant Erbitux-based chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Buprenorphine Detoxification Outcomes With Isradipine
Status: COMPLETED
Conditions: Opioid Dependence
Interventions: DRUG: Isradipine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Preoperative Relaxation and Intensified Surgery Education in Patients Undergoing Herniotomy
Status: UNKNOWN
Conditions: Hernia, Inguinal|Anxiety|Postoperative Pain
Interventions: BEHAVIORAL: relaxation program|BEHAVIORAL: surgery education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Comparison of Minimal Approach With Conventional Approach for Distal Radial Fractures
Status: COMPLETED
Conditions: Closed Frykman Type II Fracture of Right Radial Head
Interventions: PROCEDURE: Incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)
Status: RECRUITING
Conditions: Coronary Artery Disease|Heart Failure Systolic
Interventions: PROCEDURE: Revascularization by PCI|PROCEDURE: Revascularization by CABG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Test the Outdoor Usage for Sunscreen Products in Female Adults
Status: COMPLETED
Conditions: Sunscreening Agents
Interventions: DRUG: BAY987518|DRUG: Sunscreen Lotion (U77-030 Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Low-dose Dasatinib as First-line Treatment for Chronic Myeloid Leukemia
Status: UNKNOWN
Conditions: Chronic Myelogenous Leukemia
Interventions: DRUG: Dasatinib 50 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT