pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Collaborating to Heal Addiction and Mental Health in Primary Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Opioid-use Disorder|Mental Health Disorder
Interventions: OTHER: Collaborative Care for Mental Health Disorders|OTHER: Collaborative Care for Opioid Use Disorder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Dark Chocolate on Exercise Capacity, and Mitochondrial Structure and Function
Status: COMPLETED
Conditions: Heart Failure|Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Epicatechin-enriched dark chocolate|OTHER: Low-epicatechin dark chocolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Blood Volume and Hemodynamic Analysis in Patients With Chronic Heart Failure
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: PROCEDURE: blood volume measurement|PROCEDURE: venous plethysmography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Chronic Delta Hepatitis With Lonafarnib, Ritonavir and Lambda Interferon
Status: COMPLETED
Conditions: Liver Disease|Hepatitis D
Interventions: DRUG: Peg-interferon lambda|DRUG: Lonafarnib|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Response to Maternal Hyperoxygenation in Fetal Congenital Heart Disease
Status: UNKNOWN
Conditions: Hypoplastic Left Heart Syndrome|Aortic Coarctation|Atrial Septal Aneurysm
Interventions: BIOLOGICAL: Maternal hyperoxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Determine the Recommended Dose and Regimen and to Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM)
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: CC-92480|DRUG: Bortezomib|DRUG: Dexamethasone|DRUG: Daratumumab|DRUG: Carfilzomib|DRUG: Elotuzumab|DRUG: Isatuximab|DRUG: Carfilzomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Human Amniotic Membrane Allograft on Functional Recovery After Flexor Tendon Repair
Status: TERMINATED
Conditions: Flexor Tendon Injury
Interventions: PROCEDURE: The use of amnionic membrane allograft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paracetamol Versus Ibuprofen in Premature Infants With Hemodynamically Significant Patent Ductus Arteriosus
Status: UNKNOWN
Conditions: Patent Ductus Arteriosus After Premature Birth
Interventions: DRUG: Paracetamol|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose-Escalation Study Evaluating Safety and Tolerability of Viral-Specific T Cells Against CMV in Adult Solid Organ Transplant Recipients
Status: TERMINATED
Conditions: Cytomegalovirus Infections|Solid Organ Transplant
Interventions: BIOLOGICAL: CMV specific T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Better Together: Reablement and Caregivers
Status: WITHDRAWN
Conditions: Older Adults|Sedentary Behavior|Physical Activity|Caregiver
Interventions: BEHAVIORAL: Better Together|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study To Estimate The Effect Of Ketoconazole On The Pharmacokinetics Of Pf-04937319 In Healthy Subjects
Status: COMPLETED
Conditions: Human Volunteers
Interventions: DRUG: PF-04937319 / ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mini- Open Direct-anterior Approach vs Hip Arthroscopy for Treatment of Femoroacetabular Impingement.
Status: WITHDRAWN
Conditions: Femoracetabular Impingement
Interventions: PROCEDURE: Mini-open DAA|PROCEDURE: Hip arthroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Growth and Cognitive Development of the Disadvantaged Young Children in Resource Poor Setting
Status: RECRUITING
Conditions: Complementary Feeding
Interventions: OTHER: Animal source of food and psychosocial stimulation|OTHER: Animal source of food|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Evaluation of 3K3A-APC in Ischemic Stroke
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: BIOLOGICAL: 3K3A-APC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Music-based Intervention for the Reduction of Pain
Status: UNKNOWN
Conditions: Pain Perception|Autonomic Nervous System Functioning
Interventions: BEHAVIORAL: researcher-selected frequency-modulated music|BEHAVIORAL: researcher-selected non-modulated music|BEHAVIORAL: participant-selected non-modulated music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Brain Functional MRI as an Early Biomarker of Recovery in Individuals With Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Functional Electric Stimulation cycling|DEVICE: Passive cycling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Remote Ischaemic Preconditioning in Patients With Atherosclerosis Undergoing Vascular Surgery
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm|Peripheral Artery Disease|Carotid Artery Stenosis
Interventions: PROCEDURE: Remote ischaemic preconditioning|PROCEDURE: Control to RIPC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of Trastuzumab and Paclitaxel Based Regimens to Treat HER2-positive Breast Cancer
Status: UNKNOWN
Conditions: HER-2 Positive Breast Cancer
Interventions: DRUG: Trastuzumab|DRUG: Paclitaxel|DRUG: Epirubicin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Mobile Therapy for Elevated Depressive Symptoms
Status: COMPLETED
Conditions: Depressive Symptoms|Depression
Interventions: BEHAVIORAL: Behavioral Activation Therapy app|BEHAVIORAL: Behavioral Activation Therapy app + EHR|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pentoxifylline Effect in Patients With Diabetic Nephropathy.(PENFOSIDINE STUDY)
Status: UNKNOWN
Conditions: Chronic Kidney Disease stage3 and 4|Type 2 Diabetes Mellitus
Interventions: DRUG: pentoxifylline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First-Line Combination Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: docetaxel|DRUG: gemcitabine hydrochloride|DRUG: vinorelbine tartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of VISULAS Green Selective Laser Trabeculoplasty (SLT)
Status: UNKNOWN
Conditions: Primary Open-angle Glaucoma
Interventions: PROCEDURE: selective laser trabeculoplasty (SLT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Pneumonia: Pulmonary Physiology, Health-related Quality of Life and Benefit of a Rehabilitation Program
Status: UNKNOWN
Conditions: Covid19 Pneumonia|Chronic Thromboembolic Pulmonary Hypertension|Myopathy|Restrictive Lung Disease
Interventions: OTHER: Pulmonary rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 5-0 Prolene Versus 5-0 Fast Absorbing Gut
Status: COMPLETED
Conditions: Cutaneous Wound
Interventions: DEVICE: 5-0 Prolene, 5-0 Fast Absorbing Gut
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Budesonide 3x3mg/d Versus Prednisone in Active Autoimmune Hepatitis
Status: COMPLETED
Conditions: Autoimmune Hepatitis
Interventions: DRUG: budesonide|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IV Paracetamol Versus IV Dexketoprofen in Dysmenorrhea
Status: UNKNOWN
Conditions: Dysmenorrhea
Interventions: DRUG: Paracetamol|DRUG: Dexketoprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Ketamine and Magnesium Therapy for Control of Postoperative Pain After a Liposuction and Lipoabdominoplasty
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Saline|DRUG: Ketamine|DRUG: Ketamine + magnesium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: taVNS to Reduce PTSD Symptoms in WTC Responders
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic
Interventions: DEVICE: taVNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Placebo-Controlled Evaluation of Galantamine in the Treatment of Alzheimer's Disease: Safety and Efficacy of a Controlled-Release Formulation
Status: COMPLETED
Conditions: Alzheimer Disease|Dementia
Interventions: DRUG: galantamine hydrobromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Rectal Indomethacin Versus Combined Pancreatic Stent Placement and Rectal Indomethacin for Preventing Post-ERCP Pancreatitis
Status: RECRUITING
Conditions: Post-ERCP Acute Pancreatitis
Interventions: DRUG: Rectal Indomethacin|PROCEDURE: Prophylactic Pancreatic duct stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Gemcitabine Hydrochloride, Carboplatin, Dexamethasone, and Rituximab in Treating Patients With Previously Treated Lymphoid Malignancies
Status: COMPLETED
Conditions: Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Testicular Lymphoma|Waldenstrom Macroglobulinemia
Interventions: DRUG: gemcitabine hydrochloride|DRUG: carboplatin|DRUG: dexamethasone|BIOLOGICAL: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Dose Study of the Safety, Pharmacokinetics and Pharmacodynamics of MK-1064 (MK-1064-001)
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: MK-1064|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Myocardial Protection of Exenatide in AMI
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: exenatide BYETTA® (Amylin-Lilly)|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study for Fluticasone Propionate 500 mcg/Salmeterol Xinafoate 50 mcg Inhalation Powder in Healthy Volunteers
Status: RECRUITING
Conditions: Bioequivalence
Interventions: DRUG: Fluticasone propionate 500 mcg and salmeterol xinafoate 50 mcg/Respirent Pharmaceuticals|DRUG: ADVAIR DISKUS® 500/50
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Phase 1 Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of YL201 in Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: YL201
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of a Virtual Reality Cognitive Stimulation Programme for Breast Cancer Patients Wishing to Restart or Maintain a Professional Activity
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Cancer-related Cognitive Difficulties
Interventions: BEHAVIORAL: Virtual Reality sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Intensive, Home-Based Family Therapy to Improve Illness Management in Youth With Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Insulin Dependent
Interventions: BEHAVIORAL: Intensive Home-Based Family Therapy|BEHAVIORAL: Supportive Telephone Calls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Study on Bacterial Load Following Open-to-air Management in Burn Patients.
Status: WITHDRAWN
Conditions: Burns|Infection Wound|Bacterial Infections
Interventions: PROCEDURE: Open-to-air strategy|PROCEDURE: Traditional closed-wound management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Vestibular Dysfunction or Visuospatial Perception in Individuals With Idiopathic Scoliosis
Status: UNKNOWN
Conditions: Scoliosis Idiopathic|Vestibular Function Disorder|Visuospatial/Perceptual Abilities
Interventions: OTHER: Balance assessment|OTHER: Unterberger test|OTHER: Corsi Block Tapping (mobıl app)|OTHER: Navigation performance|OTHER: Cobb angle measurement|OTHER: Scolio Detector (mobıl app)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Analysis of Hypovitaminosis D and Osteopenia/Osteoporosis in Spinal Disease Patients Who Underwent a Spinal Fusion at Illinois Neurological Institute, Peoria, IL., a Retrospective Review From November 1, 2012 to October 31, 2014 and Prospective Pilot From July 1, 2015-June 30, 2016
Status: COMPLETED
Conditions: Hypovitaminosis D|Spinal Disease|Osteoporosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Transcranial Magnetic Stimulation on Cognition and Neural Changes in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease|Mild Cognitive Impairment
Interventions: DEVICE: TMS|DEVICE: Sham-TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Palatal Donor Site Wound Healing Following Periodontal Plastic Surgery Using Amnion-Chorion Membrane
Status: RECRUITING
Conditions: Palate; Wound
Interventions: OTHER: Amnion-chorion Membrane|OTHER: ActCel Cellulose Gauze
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Electroencephalogram (EEG) Enhanced Transcranial Magnetic Stimulation (eTMS) for Chronic Trauma and Stressor-Related Disorders (TSRD)
Status: RECRUITING
Conditions: Trauma and Stressor Related Disorders
Interventions: DEVICE: Adjunctive, midline prefrontal, lower intensity, shorter session, EEG-enhanced, repetitive transcranial magnetic stimulation (eTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Ratio of Hypnotic to Analgesic Potency of Volatile Anesthetics
Status: COMPLETED
Conditions: Anesthesia, General
Interventions: DRUG: Sevoflurane|DRUG: Desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Structured Caregiver Support Program (SCSP) in Terms of Various Parameters
Status: ENROLLING_BY_INVITATION
Conditions: Alzheimer Disease
Interventions: OTHER: The structured caregiver support program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Durvalumab Plus Tremelimumab With Chemotherapy in Untreated ES-SCLC
Status: TERMINATED
Conditions: Small Cell Lung Carcinoma
Interventions: COMBINATION_PRODUCT: Durvalumab + Tremelimumab in combination with carboplatin and etoposide|COMBINATION_PRODUCT: Durvalumab in combination with carboplatin and etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Efficacy of MTP-131 for the Treatment of Mitochondrial Myopathy
Status: COMPLETED
Conditions: Mitochondrial Myopathy
Interventions: DRUG: elamipretide (low dose)|DRUG: elamipretide (intermediate dose)|DRUG: elamipretide (high dose)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Systemic Zinc Sulphate in Treatment of Recurrent Aphthous Ulcerations:A Doubleblind, Placebo Controled Study
Status: COMPLETED
Conditions: Aphthous Stomatitis
Interventions: DRUG: zinc sulphate 220mg/day in one dosage|DRUG: placebo: one dosage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of New Topical Formulations in Subjects With Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis, Atopic|Eczema
Interventions: DRUG: Investigational OTC Cream|OTHER: Cosmetic Eczema Cream|DRUG: 0.05% Desonide Cream|OTHER: Placebo Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-approval Access Single Patient Request for Niraparib / Abiraterone Acetate Combination (Nira/AA Combination)
Status: APPROVED_FOR_MARKETING
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: Niraparib plus Abiraterone Acetate (Nira/AA) combination|DRUG: Prednisone/Prednisolone
Study Type: EXPANDED_ACCESS
Clinical trial: Retropubic vs. Single-Incision Mid-Urethral Sling for Stress Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence|Pelvic Floor Disorders
Interventions: DEVICE: RP sling placement|DEVICE: SIS placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Supine Versus Left Lateral Tilted Position During Cesarean Delivery
Status: UNKNOWN
Conditions: Cesarean Section Complications
Interventions: OTHER: supine position|OTHER: left lateral tilted position|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Molecular Profiling of Advanced Soft-tissue Sarcomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: Nilotinib|DRUG: Ceritinib|DRUG: Capmatinib|DRUG: Lapatinib|DRUG: Trametinib|COMBINATION_PRODUCT: Trametinib and Dabrafenib|COMBINATION_PRODUCT: Olaparib and Durvalumab|DRUG: Palbociclib|DRUG: Glasdegib|DRUG: TAS-120|OTHER: Next Generation sequencing exome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Ibudilast on Oxycodone Self-administration in Opioid Abusers
Status: COMPLETED
Conditions: Opioid Abuse|Opioid Dependence
Interventions: DRUG: MN-166 (50 mg) First|DRUG: Placebo First
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Aspirin and Antiretroviral Therapy in HIV Infected Patients
Status: TERMINATED
Conditions: HIV Infection
Interventions: DRUG: Aspirin 325mg|DRUG: Antiretroviral therapy (ART)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of OsteoStrong vs. Individually Adapted and Combined Training on Bone Health
Status: COMPLETED
Conditions: Osteoporosis|Osteopenia|Bone Density, Low|Bone Loss
Interventions: OTHER: OsteoStrong|OTHER: Individually Adapted and Combined Physical Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positive End-expiratory Pressure (PEEP) in Predicting Fluid Responsiveness in Patients Undergoing One-lung Ventilation
Status: COMPLETED
Conditions: Lung Cancer|Lung Diseases
Interventions: PROCEDURE: PEEP challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Formation of Antibodies and Subsequent Prediction of Clinical Response in Patients With Rheumatoid Arthritis Treated With Four TNF Blocking Agents
Status: TERMINATED
Conditions: Rheumatoid Arthritis (RA)
Interventions: OTHER: non-interventional study|OTHER: non-interventional study|OTHER: non-interventional study|OTHER: non-interventional study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase I, Open-Label, Single-Center Study to Assess the Absorption, Metabolism, and Excretion of [14C]-AZD3293
Status: COMPLETED
Conditions: Healthy Volunteers|Mass Balance Study
Interventions: DRUG: AZD3293
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Neuromodulation and Cognitive Training for Substance Use Disorders
Status: RECRUITING
Conditions: Stimulant Use|Alcohol Use Disorder
Interventions: DEVICE: tDCS|BEHAVIORAL: Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Probiotic Preparation (VSL#3) Plus Infliximab in Children With Crohn's Disease
Status: UNKNOWN
Conditions: Crohn's Disease
Interventions: DIETARY_SUPPLEMENT: VSL#3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acute Exposure of Simulated Hypoxia on Blood and Tissue Oxygenation (aBGA, NIRS)
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DEVICE: Simulated Altitude (FiO2: 15.1%)|DEVICE: Shamed Hypoxia (FiO2: 20.9)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Medication Effects on Periurethral Sensation,Urethral Sphincter Activity and Pressure Flow Parameters
Status: COMPLETED
Conditions: Urethral Sphincter Activity
Interventions: DRUG: Pseudoephedrine|DRUG: Tamsulosin|DRUG: Imipramine|DRUG: Cyclobenzaprine|DRUG: Lactose capsule|DRUG: Solifenacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Topic Ketorolac Added to Panphotocoagulation in Proliferative Diabetic Retinopathy
Status: COMPLETED
Conditions: Proliferative Diabetic Retinopathy|Macular Edema
Interventions: DRUG: Ketorolac tromethamine|DRUG: Polivynilic alcohol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Instep Plantar Fasciotomy With and Without Gastrocnemius Recession
Status: WITHDRAWN
Conditions: Plantar Fasciitis|Equinus Deformity
Interventions: PROCEDURE: Instep without gastrocnemius recession|PROCEDURE: Instep with gastrocnemius recession
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: European Post-Market Study for Medial Knee Osteoarthritis Treated With the Atlas Knee System for Load Reduction
Status: WITHDRAWN
Conditions: Osteoarthritis (OA) of the Medial Knee Compartment
Interventions: DEVICE: Atlas Knee System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiopulmonary Interactions in Patients With Heart Failure
Status: WITHDRAWN
Conditions: Heart Failure|Pulmonary Hypertension|Heart Failure With Reduced Ejection Fraction|Heart Failure With Normal Ejection Fraction
Interventions: DIAGNOSTIC_TEST: Lung Biopsy during LVAD Implantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Probiotics in Dementia
Status: ACTIVE_NOT_RECRUITING
Conditions: Dementia; Alzheimer, Mixed Type (Etiology)
Interventions: DIETARY_SUPPLEMENT: Omni-Biotic Stress Repair|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomised Prospective Comparison of the NMA Allograft and the Traditional Allograft in Acute Myeloid Leukaemia
Status: UNKNOWN
Conditions: Leukemia, Myeloid, Acute
Interventions: PROCEDURE: Allogenic transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Posture on Left Ventricular (LV) Transvenous Lead Capture Thresholds (EXPECT)
Status: TERMINATED
Conditions: Congestive Heart Failure
Interventions: DEVICE: Medtronic 4195 active fixation LV lead and Medtronic passive fixation LV lead
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Comparison of the Use of Natural and Synthetic Bone Substitutes in Dental Implants
Status: NOT_YET_RECRUITING
Conditions: Alveolar Ridge Augmentation
Interventions: OTHER: Bonalive|OTHER: Bio-Oss®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pelvic Floor Magnetic Stimulation in Men With Radical Prostatectomy
Status: RECRUITING
Conditions: Urinary Incontinence Episodes After the Magnetic Stimulation in Men With Radical Prostatectomy
Interventions: DEVICE: Magnetic Stimulation - Armchair type
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS
Status: RECRUITING
Conditions: Relapsing Multiple Sclerosis
Interventions: BIOLOGICAL: Ofatumumab|BIOLOGICAL: Tetanus toxoid (TT) containing vaccine (Td, Tdap)|BIOLOGICAL: 13-valent pneumococcal conjugate vaccine (13-PCV)|BIOLOGICAL: 23-valent pneumococcal polysaccharide vaccine (23-PPV)|BIOLOGICAL: Seasonal Quadrivalent influenza vaccine|BIOLOGICAL: Keyhole limpet hemocyanin (KLH) neo-antigen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability and Potential Efficacy of a Tracheal Replacement Consisting of a Tissue-engineered Tracheal Scaffold With Seeded Mesenchymal Cells
Status: SUSPENDED
Conditions: Tracheomalacia|Tracheal Stenosis
Interventions: PROCEDURE: Cadaveric decellularised tracheal scaffold seeded with autologous mesenchymal cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 15-day Study to Assess the Safety and Clinical Utility of Duragesic (Fentanyl Transdermal Patch) in the Treatment of Children With Continuous Pain Requiring Narcotic Pain Relief Therapy
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DRUG: Duragesic® (fentanyl) Transdermal Therapeutic System (TTS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PF-04856884 (CVX-060) In Combination With Axitinib In Patients With Previously Treated Metastatic Renal Cell Carcinoma
Status: TERMINATED
Conditions: Metastatic Renal Cell Carcinoma
Interventions: BIOLOGICAL: PF-04856884|DRUG: Axitinib (AG-013736)|DRUG: Axitinib (AG-013736)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Research Study Investigating How Well NDec Works in People With Sickle Cell Disease
Status: RECRUITING
Conditions: Sickle Cell Disease
Interventions: DRUG: NDec - oral decitabine-tetrahydrouridine|DRUG: HU - Hydroxyurea|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Effects of Subchronic Dopamine D2 Receptor Blockade by Haloperidol in Healthy Humans
Status: COMPLETED
Conditions: Insulin Resistance|Dyslipidemia
Interventions: DRUG: Haloperidol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Smart mHealth Strategy for Physical Activity and Health Promotion
Status: RECRUITING
Conditions: Health Behavior Change|Wearable Technology|Chatbot|Social Media|Sedentary Lifestyle
Interventions: BEHAVIORAL: Wearable devices only|BEHAVIORAL: Wearable devices with the 1st behavior change technique|BEHAVIORAL: Wearable devices with the 2nd behavior change technique|BEHAVIORAL: Wearable devices with the 3rd behavior change technique|BEHAVIORAL: Wearable devices with the 4th behavior change technique|BEHAVIORAL: Wearable devices with the 5th behavior change technique|BEHAVIORAL: Wearable devices with all behavior change techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of Symptoms Caused by Cancer and Cancer Therapy in Patients With Invasive Breast, Lung, Prostate, or Colorectal Cancer
Status: COMPLETED
Conditions: Breast Cancer|Cognitive/Functional Effects|Colorectal Cancer|Lung Cancer|Pain|Prostate Cancer|Psychosocial Effects of Cancer and Its Treatment
Interventions: PROCEDURE: assessment of therapy complications|PROCEDURE: cognitive assessment|PROCEDURE: psychosocial assessment and care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: OPTIMUS PRIME: Safety and Feasibility of OPTune GIO® Integrated With MRI-gUided Laser Ablation Surgery and Pembrolizumab for Recurrent GlIoblastoMa, A randomizEd Trial
Status: NOT_YET_RECRUITING
Conditions: Recurrent Glioblastoma
Interventions: DRUG: Pembrolizumab|DEVICE: Optune GIO®|DEVICE: NeuroBlate®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AS900672-Enriched in Ovulation Induction
Status: TERMINATED
Conditions: Ovulation Induction
Interventions: DRUG: AS900672-Enriched 10 microgram (mcg)|DRUG: AS900672-Enriched 20 mcg|DRUG: AS900672-Enriched 30 mcg|DRUG: AS900672-Enriched 40 mcg|DRUG: Follitropin alfa 75 international unit (IU)|DRUG: Recombinant human chorionic gonadotropin (r-hCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fasciotens to Treat an Open Abdomen - a Prospective Cohort Study
Status: RECRUITING
Conditions: Abdominal Compartment Syndrome|Pancreatitis,Acute Necrotizing|Intraabdominal Hypertension|Peritonitis
Interventions: DEVICE: Fasciotens-Abdomen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Treating Insomnia on Behavioral Weight Loss Outcomes in Survivors of Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Insomnia|Weight Gain
Interventions: BEHAVIORAL: Cognitive-Behavioral Therapy for Insomnia (CBT-I)|BEHAVIORAL: Sleep Education Control (EDU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial on the Combination of Avelumab and Axitinib for the Treatment of Patients With Recurrent Glioblastoma
Status: COMPLETED
Conditions: Recurrent Glioblastoma (WHO-Grade IV Glioma)
Interventions: DRUG: Axitinib|DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Pilot Study of Aminoimidazole Carboxamide Riboside (AICAR), a Precursor of Purine Synthesis, for Lesch-Nyhan Disease
Status: COMPLETED
Conditions: Lesch-Nyhan Syndrome
Interventions: DRUG: aminomidazole carboxamide riboside
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Subcutaneous Versus Intravenous Administration of RoActemra/Actemra (Tocilizumab) in Participants With Moderate to Severe Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tocilizumab SC|DRUG: tocilizumab IV|DRUG: placebo to tocilizumab SC|DRUG: placebo to tocilizumab IV|DRUG: Disease-modifying antirheumatic drugs (DMARDs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nerve Block Versus General Anaesthesia for Distal Radial Fracture Surgery
Status: COMPLETED
Conditions: Acute Pain
Interventions: PROCEDURE: Infraclavicular nerve block|PROCEDURE: General anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Individualized Homeopathy to Reduce the Use of Antibiotics in Women With Recurrent Uncomplicated Urinary Tract Infections
Status: RECRUITING
Conditions: Urinary Tract Infection Chronic
Interventions: DRUG: One out of 140 predefined homeopathic medical products (HMP) in potency C200 or C1000,
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-fucosylated Anti-CTLA-4 (BMS-986218) + Degarelix Acetate vs. Degarelix Acetate Alone in Men With High-risk Localized Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: BMS-986218 and Degarelix|DRUG: Degarelix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correlation of Blood Gene Expression (TruGraf Liver) With Liver Biopsy in Pediatric Liver Transplant Recipients
Status: RECRUITING
Conditions: Liver Transplant; Complications|Liver Failure, Acute
Interventions: DIAGNOSTIC_TEST: TruGraf® Liver gene expression panel (GEP)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Fospropofol Disodium Versus Propofol for Deep Sedation in Critically Ill Patients
Status: RECRUITING
Conditions: Critical Illness
Interventions: DRUG: Fospropofol disodium for injection|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Camrelizumab Plus Stereotactic Body Radiotherapy vs Camrelizumab Alone For Oligometastatic Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: camrelizumab|RADIATION: stereotactic body radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Loteprednol vs. Prednisolone and Fluorometholone
Status: COMPLETED
Conditions: Intraocular Pressure|Corneal Opacity
Interventions: DRUG: Loteprednol Etabonate 0.5% Oph Gel|DRUG: Prednisolone Acetate 1% Oph Susp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of SlimBiotics Probiotic Formula on Weight Management and Metabolic Health Outcomes
Status: COMPLETED
Conditions: Metabolic Health|Weight Loss|Stress|Well-Being, Psychological|Sleep|Healthy Eating
Interventions: OTHER: Slimbiotic Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Prophylactic Acetaminophen for Prevention Intraventricular Hemorrhage in Premature Infants
Status: UNKNOWN
Conditions: Intraventricular Haemorrhage Neonatal
Interventions: DRUG: Acetaminophen|DRUG: Dextrose 5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PET/CT* vs. Cardiac CT for Detecting Coronary Atherosclerotic Disease [*PET: Positron Emission Tomography; CT: Computed Tomography]
Status: RECRUITING
Conditions: Coronary Artery Disease|Atherosclerosis|Coronary Atherosclerosis of Native Coronary Artery
Interventions: DIAGNOSTIC_TEST: PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Medico-economic Evaluation Comparing the Use of Ultrasonic Scissors to the Conventional Techniques of Haemostasis in Thyroid Surgery by Cervicotomy
Status: UNKNOWN
Conditions: Thyroid Tumor
Interventions: DEVICE: Ultrasonic Scissors (Ethicon)|DEVICE: Bipolar Electrosurgical instruments (Medtronic) (SLS- Clips)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Superiority Trial of the SUPERA Peripheral Stent System in Patients With Femoro-popliteal Artery Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: Supera® Peripheral Stent System|DEVICE: EverFlex™ Self-Expanding Peripheral Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of KBP-5074 in Healthy Subjects and Subjects With Renal Impairment
Status: COMPLETED
Conditions: Healthy|Renal Insufficiency
Interventions: DRUG: KBP-5074
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palliative Radiotherapy in Symptomatic Pelvic Soft Tissue Tumors
Status: NOT_YET_RECRUITING
Conditions: Gastrointestinal Cancer|Urologic Cancer|Gynecologic Cancer
Interventions: RADIATION: Palliative radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Use of Nasal IFN-γ in Patients for the Prevention of Acute Respiratory Viral Infections, Icluding COVID-19
Status: COMPLETED
Conditions: COVID-19 Respiratory Infection|Acute Respiratory Disease
Interventions: DRUG: Interferon gamma human recombinant (IFN-G)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study Evaluating Ultratrace Iobenguane I131 in Patients With Malignant Relapsed/Refractory Pheochromocytoma/Paraganglioma
Status: UNKNOWN
Conditions: Pheochromocytoma|Paraganglioma
Interventions: RADIATION: Ultratrace® Iobenguane I131
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Pharmacodynamic and Pharmacokinetic Interaction Between Aliskiren and Furosemide in Patients With Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Aliskiren 150 mg|DRUG: Furosemide 60 mg|DRUG: Placebo for Aliskiren|DRUG: Aliskiren 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Inspiratory Muscle Training in Operated Adolescent Idiopathic Scoliosis
Status: COMPLETED
Conditions: Scoliosis Idiopathic Adolescent
Interventions: DEVICE: Inspiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dairy and Non-dairy Alternatives on Satiety and Post-meal Glycemia in Healthy Young Adults
Status: COMPLETED
Conditions: Diabetes|Obesity
Interventions: OTHER: 1% M.F. Milk|OTHER: Yogurt Beverage|OTHER: Soy Beverage|OTHER: Almond Beverage|OTHER: Water|OTHER: Breakfast cereal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of TD101, a Small Interfering RNA (siRNA) Designed for Treatment of Pachyonychia Congenita
Status: COMPLETED
Conditions: Pachyonychia Congenita
Interventions: DRUG: TD101|DRUG: Normal saline (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mepolizumab to CRSwNP Through 12 Months - Randomised to FESS and Non-FESS Within the First 2 Weeks
Status: RECRUITING
Conditions: Chronic Rhinosinusitis With Nasal Polyps|Asthma
Interventions: BIOLOGICAL: Mepolizumab Injection|PROCEDURE: Functional Endoscopic Sinus Surgery (FESS).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eliminating Narcotic Prescriptions From Outpatient Minimally Invasive Gynecologic Surgery
Status: RECRUITING
Conditions: Pain, Postoperative|Opioid Use
Interventions: OTHER: prescription for regular acetaminophen and naproxen|OTHER: prescription for regular acetaminophen , naproxen and dilaudid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Daily Dosing With Levalbuterol, Racemic Albuterol, and Placebo in Pediatric Subjects With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Levalbuterol tartrate MDI|DRUG: racemic albuterol MDI|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Lebrikizumab (LY3650150) in Combination With Topical Corticosteroids in Japanese Participants With Moderate-to-Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis, Atopic|Dermatitis|Eczema|Skin Diseases|Skin Diseases, Genetic
Interventions: DRUG: Lebrikizumab|DRUG: Placebo|DRUG: Topical Corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Hemodialysis Catheter Removal and Delayed Replacement, Versus Exchange Over a Guidewire to Treat Catheter Related Blood Stream Infection
Status: COMPLETED
Conditions: Catheter Related Blood Stream Infection
Interventions: DEVICE: catheter replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT