pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: CFI-402257, a Potent and Selective TTK Inhibitor, in Solid Tumors and With Fulvestrant in Breast Cancer
Status: RECRUITING
Conditions: Advanced Solid Tumor|Breast Cancer
Interventions: DRUG: CFI-402257|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of TG01 and Erlotinib in Non-small Cell Lung Cancer (NCSLC) Patients
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: TG01
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Shear Wave Elastography in Differentiating Acute or Chronic Kidney Disease
Status: RECRUITING
Conditions: Elastography|Chronic Kidney Diseases
Interventions: DIAGNOSTIC_TEST: Shear wave elastography to distinguish AKI from normal kidney|DIAGNOSTIC_TEST: Shear wave elastography to distinguish AKI from CKD|DIAGNOSTIC_TEST: Shear wave elastography to distinguish CKD from normal kidney
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetic Comparability of Benralizumab Using Accessorized Pre-Filled Syringe or Autoinjector in Healthy Volunteers
Status: COMPLETED
Conditions: Asthma|Chronic Obstructive Pulmonary Disease
Interventions: BIOLOGICAL: Benralizumab|BIOLOGICAL: Benralizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The 'Lombard Effect' in Patients Affected by Adductor Laryngeal Dystonia
Status: NOT_YET_RECRUITING
Conditions: Adductor Spasmodic Dysphonia
Interventions: OTHER: Lombard test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effects of Hemodilution Methods in Patients Undergoing Primary Debulking Gynaecological Surgery
Status: COMPLETED
Conditions: Ovarian Neoplasm Epithelial
Interventions: OTHER: acute normovolemic hemodilution (ANH)|OTHER: acute hypervolemic hemodilution (AHH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Intravenous Fentanyl Prior the End of Surgery on Emergence Agitation in Paediatric Patients After General Anesthesia
Status: COMPLETED
Conditions: Agitation
Interventions: DRUG: fentanyl|DRUG: NSS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: UCLA-Amity Parolee Health Promotion Study
Status: COMPLETED
Conditions: Hepatitis B|Hepatitis C|HIV|Drug Addiction
Interventions: BEHAVIORAL: Parolee Comprehensive Care + Phone Coach|BEHAVIORAL: Parolee Brief HBV Program + Phone Coach|BEHAVIORAL: Usual Care Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Dialysate Sodium Individualization in Hemodialysis
Status: TERMINATED
Conditions: Hypertension|Hemodialysis Patients
Interventions: DRUG: dialysate sodium individualization|DRUG: standard dialysate sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Mycophenolate Mofetil (MMF) on Renal Outcomes in Advanced Immunoglobulin A (IgA) Nephropathy Patients
Status: COMPLETED
Conditions: IgA Nephropathy
Interventions: DRUG: Mycophenolate mofetil|DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bupropion Hydrochloride 300 mg Extended Release Tablets Under Fasting Conditions
Status: TERMINATED
Conditions: Depressive Disorder
Interventions: DRUG: Bupropion HCl|DRUG: Bupropion HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Eye Movement Desensitization and Reprocessing Group Treatment for Caregivers of Pediatric Brain Tumor Patients
Status: RECRUITING
Conditions: Caregiver Burden
Interventions: OTHER: Eye Movement Desensitization and Reprocessing Integrative Group Treatment Protocol|OTHER: Treatment As Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Automated Medication Platform With Video Observation and Facial Recognition to Improve Adherence to Antiretroviral Therapy in Patients With HIV/AIDS
Status: COMPLETED
Conditions: HIV Infections
Interventions: DEVICE: HiDO medication adherence platform|DEVICE: Automated Medication Platform with Video Observation|OTHER: Time on Task
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia - VECTOR II
Status: COMPLETED
Conditions: Innate Immune Response|Endotoxemia|Inflammation|Sepsis
Interventions: DRUG: C1-esterase inhibitor|DRUG: Endotoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate SGB-3403 in Healthy Volunteers and Subjects With Elevated Low-Density Lipoprotein Cholesterol (LDL-C)
Status: NOT_YET_RECRUITING
Conditions: Hyperlipidemias
Interventions: DRUG: SGB-3403|OTHER: Atorvastatin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Caregiver Support in the Coping of Patients Who Are Undergoing a Donor Bone Marrow Transplant
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases|Psychosocial Effects of Cancer and Its Treatment
Interventions: PROCEDURE: psychosocial assessment and care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study on the Regenerative Treatment of Tympanic Membrane With NPC-18 and FBG-18
Status: COMPLETED
Conditions: Tympanic Membrane Perforation
Interventions: DRUG: fiblast,gelatin sponge,fibrin glue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Postpartum Pelvic Floor Rehabilitation in Prevention and Treatment of Pelvic Floor Dysfunction
Status: UNKNOWN
Conditions: Primiparous Women With Singleton Baby at Term
Interventions: DEVICE: PHENIX Neuromuscular Stimulation Therapy System device|OTHER: usual home care without device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PTSC: Improving Hypertension Control Among Poor Midlife African American Women
Status: COMPLETED
Conditions: Uncontrolled Hypertension|BMI|Stress|Medication Adherence
Interventions: BEHAVIORAL: Prime Time Sister Circle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Busulfan, Fludarabine, Clofarabine With Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome|Chronic Myeloid Leukemia
Interventions: DRUG: Clofarabine|DRUG: Busulfan|DRUG: Fludarabine|OTHER: Stem Cell Infusion|DRUG: Thymoglobulin (ATG)|DRUG: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Virus Activated Killer Immune Cells (VAK) for Malignant Pleural and Peritoneal Effusion
Status: UNKNOWN
Conditions: Malignant Pleural Effusion|Malignant Peritoneal Effusion
Interventions: DRUG: Virus Activated Killer immune Cells|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study the Role of Positron Emission Mammography in Pre-surgical Planning for Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: PROCEDURE: Positron Emission Mammography|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene
Status: RECRUITING
Conditions: Malignant Solid Neoplasm
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Echocardiography|PROCEDURE: Multigated Acquisition Scan|DRUG: Neratinib Maleate|BIOLOGICAL: Trastuzumab Deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Intravenous Brivaracetam in Subjects >= 1 Month to < 16 Years of Age With Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Brivaracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation for IBS
Status: RECRUITING
Conditions: Irritable Bowel Syndrome|Diarrhea
Interventions: BIOLOGICAL: Donor Fecal Microbiota Transplantation|BIOLOGICAL: Autologous Fecal Microbiota Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TCD Detection of Gas and Solid Micro-Emboli in Patients Undergoing Coronary Artery Bypass Grafting (CABG): The Influence of Proximal Anastomosis Technique
Status: UNKNOWN
Conditions: Intracranial Embolism and Thrombosis|Postoperative Complications
Interventions: DEVICE: Proximal anastomosis using Heartstring anastomotic device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Berberine Effect on Cytokine, CRP, Metabolic Disturbance as an Adjunctive Therapy in Schizophrenia Patients
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Berberine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Transcranial Direct Current Stimulation of the Somatosensory Area on Upper Limb Motor Performance
Status: UNKNOWN
Conditions: Healthy
Interventions: DEVICE: HD-tDCS 1 mA to S1|DEVICE: HD-tDCS 1 mA to M1|DEVICE: Sham control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Imaging Neuromelanin and Iron in Dystonia/Parkinsonism
Status: UNKNOWN
Conditions: Sporadic Dystonia|Dystonia, Familial|Parkinson Disease, Juvenile|Neurodegeneration With Brain Iron Accumulation 5|Mitochondrial Diseases
Interventions: DIAGNOSTIC_TEST: 3Tesla MRI|BEHAVIORAL: Burke-Fahn-Marsden Dystonia Rating scale|BEHAVIORAL: MDS-United Parkinsons Disease Rating Scale, Part III|BEHAVIORAL: Beck Depression Inventory|BEHAVIORAL: MoCA: Montreal Cognitive Assessment:
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial to Learn if ALN-PNP is Safe and Well Tolerated in Healthy Adults and Adult Participants With Non-Alcoholic Fatty Liver Disease (NAFLD)
Status: RECRUITING
Conditions: Healthy Volunteers|Non-alcoholic Fatty Liver Disease (NAFLD)
Interventions: DRUG: ALN-PNP - Part A|DRUG: ALN-PNP - Part B|DRUG: Placebo (PB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-dose Radiotherapy and Neoadjuvant Chemotherapy Sequential Concurrent Chemoradiotherapy for Locally Advanced Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Locally Advanced Nasopharyngeal Carcinoma
Interventions: RADIATION: low-dose radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: the Safety, Tolerability, and Pharmacokinetics Study of HEC113995
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: OTHER: Food|DRUG: HEC113995|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Double Blind Controlled Trial Comparing the Safety and Efficacy of Apremilast Versus Placebo in Severe Forms of Recurrent Aphthous Stomatitis
Status: NOT_YET_RECRUITING
Conditions: Recurrent Aphtous Stomatitis
Interventions: DRUG: Apremilast|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Chemotherapy for High-risk Retinoblastoma After Enucleation
Status: ACTIVE_NOT_RECRUITING
Conditions: Retinoblastoma
Interventions: DRUG: 3 cycles chemotherapy|DRUG: 6 cycles chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AT247, NovoRapid® and Fiasp® in Glucose Clamp Study
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: BIOLOGICAL: NovoRapid|BIOLOGICAL: Fiasp|BIOLOGICAL: AT247
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Compound Herbal Formula (RHD-1) on HBV Carrier With Abnormal Liver Function
Status: COMPLETED
Conditions: Liver Dysfunction
Interventions: OTHER: Compound Herbal Formula (RHD-1)|OTHER: dilute RHD-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Cladribine Plus Homoharringtonine and Cytarabine Regimen (CHA) for de Novo Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia, Adult
Interventions: DRUG: cladribine + homoharringtonine + cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of the Couple-based Family Nursing for Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Women|Mastectomy|Breast-Conserving Surgery
Interventions: OTHER: Couple-based family nursing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EXPLORE FMR: Early Feasibility Study of the PLAR Implant and Delivery System to Treat Functional Mitral Regurgitation
Status: NOT_YET_RECRUITING
Conditions: Functional Mitral Regurgitation
Interventions: DEVICE: Transcatheter mitral valve repair (PLAR Implant and Delivery System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Combining Donepezil With Perceptual Learning in Normal and Amblyopic Human The Effect of Donepezil on Perceptual Learning in Adult Amblyopia
Status: COMPLETED
Conditions: Amblyopia
Interventions: DRUG: Donepezil|BEHAVIORAL: Single-letter training|BEHAVIORAL: Uncrowd training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of TNF-α Blockade Effect in Patients With Severe Cutaneous Adverse Drug Reactions
Status: COMPLETED
Conditions: Drug Hypersensitivity
Interventions: DRUG: anti- TNF-a|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Open-label, Comparative Study to Evaluate an Intermittent Dosing Regimen of Fluticasone Propionate 0.05% Cream (Twice Per Week) in Reducing the Risk of Relapse When Added to Regular Daily Moisturization Using PHYSIOGEL Lotion in Paediatric Subjects With Stabilized Atopic Dermatitis
Status: COMPLETED
Conditions: Skin Diseases
Interventions: DRUG: Fluticasone propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Trial for Adults With Partial Seizures
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Talampanel|DRUG: Placebo|DRUG: Talampanel|DRUG: Talampanel|DRUG: Placebo|DRUG: Talampanel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing Wound Drainage and Post-operative Complications With and Without the Use of EVICEL™ Fibrin Sealant in Thyroidectomy
Status: COMPLETED
Conditions: Thyroid Neoplasm|Goiter
Interventions: DRUG: EVICEL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Feasibility of Motivational Interviewing on Emotional Intelligence, Dispositional Optimism, and Adherence to Care Practices Among Patients With Permanent Pacemaker
Status: RECRUITING
Conditions: Pacemaker DDD
Interventions: BEHAVIORAL: Motivational interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of the Safety and Tolerance of CAN04 and Pembrolizumab in Combination With and Without Carboplatin and Pemetrexed in Subjects With Solid Tumors
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung|Urothelial Carcinoma|Malignant Melanoma|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: CAN04|DRUG: Pembrolizumab|DRUG: Carboplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo-Controlled Single Dose Study to Evaluate Safety and Pharmacokinetics of GMI-1359 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GMI-1359|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Patient-Reported Outcomes Following Chemoradiotherapy for Locally Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: COMBINATION_PRODUCT: PET-based, dose-painted, accelerated chemoradiotherapy|COMBINATION_PRODUCT: Standard chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacitidine, Mitoxantrone Hydrochloride, and Etoposide in Treating Older Patients With Poor-Prognosis Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Megakaryoblastic Leukemia|Adult Acute Monoblastic Leukemia|Adult Acute Monocytic Leukemia|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With Maturation|Adult Acute Myeloid Leukemia With Minimal Differentiation|Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1|Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3-MLL|Adult Acute Myeloid Leukemia Without Maturation|Adult Acute Myelomonocytic Leukemia|Adult Erythroleukemia|Adult Pure Erythroid Leukemia|Alkylating Agent-Related Acute Myeloid Leukemia|Recurrent Adult Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|DRUG: Etoposide|OTHER: Laboratory Biomarker Analysis|DRUG: Mitoxantrone Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of BI 10773 as add-on to Insulin Regimen in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Obesity
Interventions: DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: BI 10773|DRUG: BI 10773
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders
Status: COMPLETED
Conditions: Soil-transmitted Helminthiasis|Schistosomiasis|Strongyloidiasis|Shigellosis|Intestinal Salmonellosis|Campylobacteriosis|Aeromonas Spp. Infections|Giardiasis|Amoebiasis|Dientamoebiasis|Cryptosporidium Spp. Infections
Interventions: PROCEDURE: Stool culturing for pathogenic bacteria|PROCEDURE: Kato-Katz technique|PROCEDURE: Baermann technique|DEVICE: Mini-FLOTAC|DEVICE: Crypto/Giardia Duo Strip|PROCEDURE: Formalin-ether concentration technique|DEVICE: CCA RDT|PROCEDURE: Koga agar plate culture|PROCEDURE: Kinyoun staining|DEVICE: Multiplex PCR|PROCEDURE: Metagenomics analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Two Phacoemulsification-methods: Low Fluidic EasyTip 2.2mm vs. High Fluidic EasyTip 2.2mm
Status: COMPLETED
Conditions: Cataracts
Interventions: PROCEDURE: cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Pilot Study of GWP42003 in the Symptomatic Treatment of Ulcerative Colitis (GWID10160)
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: GWP42003|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 24-week Single-blind Trial of Prevention of Hand Eczema in Cleaners
Status: COMPLETED
Conditions: Hand Eczema
Interventions: BEHAVIORAL: Change in the incidence of hand eczema|BEHAVIORAL: Change in severity of hand eczema|BEHAVIORAL: Change in the number of self-reported days with absence from work due to having hand eczema|BEHAVIORAL: Change in the number of participants being forced to change their job due to having hand eczema|BEHAVIORAL: Change in The Quality Of Life in in relation to hand eczema|BEHAVIORAL: Change in the level of knowledge regarding skin care and protection.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Dose Escalation Trial of an Intravitreal Injection of Sirna-027 in Patients With Subfoveal Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Age-Related Macular Degeneration|Choroidal Neovascularization
Interventions: DRUG: AGN211745|DRUG: AGN211745|DRUG: AGN211745|DRUG: AGN211745|DRUG: AGN211745|DRUG: AGN211745
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Citrus Products on Cardiovascular Health
Status: COMPLETED
Conditions: Healthy|Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: Blood orange juice|DIETARY_SUPPLEMENT: Control drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Personalized Pacing: A New Paradigm for Patients With Diastolic Dysfunction or Heart Failure With Preserved Ejection Fraction
Status: COMPLETED
Conditions: Pacemaker|Diastolic Dysfunction|Diastolic Heart Failure
Interventions: DEVICE: Adjustment of lower rate limit|DEVICE: Maintenance of lower rate limit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improved Diagnostics, Treatment and Follow-up of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Status: NOT_YET_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease Exacerbation|Pneumonia|Respiratory Tract Infections
Interventions: DEVICE: Rapid diagnostics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence Study of Amoxicillin-Clavulanic Acid 600 mg - 42.9 mg/ 5 mL Oral Suspension Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Amoxicillin-Clavulanic acid 600mg - 42.9 mg/ 5 mL oral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: PEMF and PEC Blocks in Mastectomy Reconstruction Patients
Status: COMPLETED
Conditions: Breast Cancer Female
Interventions: DRUG: Bupivacaine Hydrochloride|OTHER: Placebo Drug|DEVICE: Pulsed Electromagnetic Field (PEMF) Device|OTHER: Placebo Device|DRUG: Ropivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Fully-closed Loop, Pramlintide and Insulin, Artificial Pancreas Clinical Trial for Adults With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Fiasp|DEVICE: Artificial Pancreas|DRUG: Pramlintide|DRUG: Aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Carbon-14-Labeled LY2835219 ([^14C]-LY2835219) in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: [^14C]-LY2835219
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Determine the Efficacy and Safety of Romosozumab in the Treatment of Postmenopausal Women With Osteoporosis
Status: COMPLETED
Conditions: Postmenopausal Women With Osteoporosis
Interventions: BIOLOGICAL: Romosozumab|DRUG: Alendronate|DRUG: Placebo to Romosozumab|DRUG: Placebo to Alendronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Perifosine + Sorafenib for Patients With Advanced Cancers
Status: COMPLETED
Conditions: Renal Cancer|Tumors
Interventions: DRUG: Perifosine|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines
Status: COMPLETED
Conditions: Lateral Canthal Lines|Crow's Feet|Facial Wrinkles
Interventions: DRUG: RT001|DRUG: RT001|DRUG: RT001|DRUG: RT001|OTHER: Vehicle Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Results of Two Different Methods in Management of Antero-lateral Instability of the Knee
Status: RECRUITING
Conditions: Anterior Cruciate Ligament Injuries
Interventions: PROCEDURE: ACL reconstruction combined with anterolateral ligament reconstruction using peroneus longus autograft|PROCEDURE: ACL reconstruction combined with extra-articular tenodesis (Modified Lemaire)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Accuracy of Direct Digital Intra-oral Scanning Measurements Compared to Measurements on Study Models
Status: COMPLETED
Conditions: Orthodontics|Study Models|Intra-oral Scanning|Measurements|Digital|Three Dimensional
Interventions: DEVICE: 3Shape TRIOS (R)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Post-authorisation Safety Study in Patients With Type 2 Diabetes to Assess the Risk of Liver Injury, Kidney Injury, Urinary Tract and Genital Infections, and Diabetic Ketoacidosis in Patients Treated With Empagliflozin, Compared to DPP-4 Inhibitors
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Empagliflozin|DRUG: DPP-4 inhibitors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Right Bifocal Ventricular Cardiac Pacing on Serum Level Natriuretic Peptides in Patients With Heart Failure
Status: UNKNOWN
Conditions: Heart Failure
Interventions: DEVICE: Pacemaker Biotronik: apical stimulation|DEVICE: Pacemaker Biotronik: bifocal stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Evaluation of Cow Milk-Based Formulas
Status: COMPLETED
Conditions: Term Infants
Interventions: OTHER: Marketed infant formula with DHA and ARA|OTHER: Milk-based infant formula with DHA and ARA|OTHER: Milk-based formula with DHA, ARA, prebiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Pulsatile GnRH Therapy on Male Patients With Pituitary Stalk Interruption Syndrome
Status: UNKNOWN
Conditions: Hypogonadotropic Hypogonadism
Interventions: DRUG: Gonadotropin-releasing Hormone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Intervention to Influence Muscle Plasticity in Veterans
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: BEHAVIORAL: Low-force muscle stimulation|BEHAVIORAL: High-force muscle stimulation|BEHAVIORAL: Sequential low-force and high-force muscle stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Controlled Trial to Increase Detection and Treatment of Osteoporosis in Older Patients With a Wrist Fracture
Status: COMPLETED
Conditions: Osteoporosis|Wrist Fractures
Interventions: BEHAVIORAL: Multifaceted intervention (patient education, physician guidelines, reminders)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Split-dose Citrafleet Administered From 2 to 6 Hours Before Morning Colonoscopies
Status: UNKNOWN
Conditions: Bowel Cleansing|Colonoscopy
Interventions: DRUG: Sodium picosulphate, magnesium oxid and citric acid|DRUG: Sodium picosulphate/magnesium oxide and citric acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prospective Comparison of Breast MRI vs Contrast Mammography Prior to Surgery in Breast Cancer Patients
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DIAGNOSTIC_TEST: Breast MRI|DIAGNOSTIC_TEST: Contrast Enhanced Mammography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Walnuts and Glucose Variability
Status: TERMINATED
Conditions: Type-2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Full dose|DIETARY_SUPPLEMENT: Half dose|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Drotrecogin Alfa (Activated) in Adult Patients With Septic Shock
Status: COMPLETED
Conditions: Sepsis
Interventions: DRUG: Drotrecogin alfa (activated)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Clinical Trial of Human Anti-PD-L1 Antibody Injection (LDP) in Patients With Advanced Malignant Tumors
Status: UNKNOWN
Conditions: Advanced Tumors
Interventions: DRUG: Whole Human Anti-PD-L1 Antibody Injection (LDP)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of the StablePoint Catheter and Force Sensing System for Paroxysmal Atrial Fibrillation
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: Treatment with IntellaNav StablePoint Ablation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Piritrexim in Treating Patients With Advanced Cancer of the Urinary Tract
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter|Urethral Cancer
Interventions: DRUG: piritrexim
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Prospective Double-blinded Randomized Controlled Trial of 12-weeks High Dose Rabeprazole (Pariet) in the Treatment of Reflux Laryngitis in Chinese Patients
Status: COMPLETED
Conditions: Gastroesophageal Reflux|Laryngitis
Interventions: DRUG: Rabeprazole 20mg twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Single Dose Study Of PF-06678552 In Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06678552 or Placebo|DRUG: PF-06678552 or Placebo|DRUG: PF-06678552 or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Remote Ischemic Conditioning for Chronic Cerebral Artery Occlusion
Status: UNKNOWN
Conditions: Cerebral Artery Occlusion
Interventions: DEVICE: Remote ischemic conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Recurrent Venous Thromboembolism (PREVENT)
Status: COMPLETED
Conditions: Cardiovascular Diseases|Heart Diseases|Peripheral Vascular Diseases|Thromboembolism|Vascular Diseases|Venous Thromboembolism
Interventions: DRUG: warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Pivotal Study of Proton Radiotherapy Treatments Using Fixed Beam Chair-Based Delivery System
Status: RECRUITING
Conditions: Thoracic Cancer|Pancreatic Cancer Non-resectable|Brain Cancer|Head Cancer|Neck Cancer
Interventions: DEVICE: Proton Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CellCept (Mycophenolate Mofetil) in Combination Therapy in Heart Transplant Patients.
Status: COMPLETED
Conditions: Heart Transplantation
Interventions: DRUG: mycophenolate mofetil (MMF)|DRUG: cyclosporine A (CsA)|DRUG: corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Study Between HEC74647PA Capsule and HEC110114 Tablets in Healthy Subjects
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: HEC74647|DRUG: HEC110114
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Tactile Deficit on Motor Function in Unilateral Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Rehabilitation|Tactile Perception
Interventions: DIAGNOSTIC_TEST: Semmes-Weinstein monofilament test|DIAGNOSTIC_TEST: Box and Block Test|DIAGNOSTIC_TEST: 9-Hole Peg Test|DIAGNOSTIC_TEST: Duruöz Hand Index (DHI)|DIAGNOSTIC_TEST: Jamar hand dynamometer|DIAGNOSTIC_TEST: Hydraulic pinch gauge
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A 52-week, Placebo- and Active- Controlled (Roflumilast, Daliresp® 500µg) Study to Evaluate the Efficacy and Safety of Two Doses of CHF6001 DPI (Tanimilast) as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis. (PILLAR)
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: CHF6001 1600µg|DRUG: CHF6001 3200µg|DRUG: Placebo|DRUG: Roflumilast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SERUM VITAMIN B12 LEVELS IN PATIENTS WITH HEMORRHAGIC VS ISCHEMIC CEREBROVASCULAR EVENT.
Status: RECRUITING
Conditions: Cerebrovascular Event|Vitamin b12|Hemorrhagic Stroke|Ischemic Stroke
Interventions: DIAGNOSTIC_TEST: Measure serum vitamin b12 levels
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Sternal Wound Infiltration With Liposomal Bupivacaine v. Bupivacaine Hydrochloride
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Artery Stenoses|Valve Regurgitation, Mitral|Valve Regurgitation, Tricuspid
Interventions: DRUG: Exparel Injectable Product|DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Transgenic Lymphocyte Immunization (TLI) Against Telomerase in Subjects With Stage III Melanoma
Status: UNKNOWN
Conditions: Stage IIIB Skin Melanoma|Stage IIIC Skin Melanoma
Interventions: BIOLOGICAL: CB-10-01 (Transgenic Lymphocyte Immunization)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Eight-week Study to Evaluate the Efficacy and Safety of Saredutant in Patients With Depression
Status: COMPLETED
Conditions: Depressive Disorder
Interventions: DRUG: Saredutant succinate (SR48968C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-Myeloablative Allogeneic Transplantation From Unrelated Donors in Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: PROCEDURE: Transplantation|PROCEDURE: Hematopoietic cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HLA-B*5801 Screening to Prevent Allopurinol-induced Severe Cutaneous Adverse Reaction
Status: UNKNOWN
Conditions: Stevens-Johnson Syndrome|Kidney Failure, Chronic
Interventions: GENETIC: HLA-B*5801 test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION FOR FAILED BACK SURGERY SYNDROME
Status: COMPLETED
Conditions: Failed Back Surgery Syndrome
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation|DEVICE: Sham Repetitive transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose-Finding Study of Birabresib (MK-8628), a Small Molecule Inhibitor of the Bromodomain and Extra-Terminal (BET) Proteins, in Adults With Selected Advanced Solid Tumors (MK-8628-003)
Status: COMPLETED
Conditions: NUT Midline Carcinoma|Triple Negative Breast Cancer|Non-small Cell Lung Cancer With Rearranged ALK Gene/Fusion Protein or KRAS Mutation|Castrate-resistant Prostate Cancer|CRPC|Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: Birabresib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating the Efficacy and the Safety of FOLFIRINOX3 Treatment in Patients With Unresectable Locally Advanced or Metastatic Pancreatic Cancer in First Line of Chemotherapy
Status: RECRUITING
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: FOLFIRINOX treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Therapy and Contrast-enhanced Mammography for Early Stage Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Locally Advanced Breast Cancer|Neoadjuvant Chemotherapy|HER2-positive Breast Cancer|Triple Negative Breast Cancer|TNBC, Triple Negative Breast Cancer
Interventions: DIAGNOSTIC_TEST: CEDM|DIAGNOSTIC_TEST: CEDBT|DRUG: Omnipaque 350mgI/mL Solution for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Zactima in Non Small Cell Lung Cancer (NSCLC) ELderly Patients In Combination With or Versus Gemcitabine
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: ZD6474, Vandetanib|DRUG: Placebo to Match ZD6474, Vandetanib|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single and Multiple Dose Study to Explore the Safety Of JNJ-40346527 In Healthy Volunteers
Status: COMPLETED
Conditions: Health
Interventions: DRUG: JNJ-40346527/Placebo|DRUG: JNJ-40346527/Placebo|DRUG: JNJ-40346527
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut Syndrome
Status: RECRUITING
Conditions: Dravet Syndrome (DS)|Lennox Gastaut Syndrome (LGS)
Interventions: DRUG: Soticlestat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clamp Study Comparing Inhalation of Technosphere®/Insulin in Smokers and Non-Smokers With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Type 2
Interventions: DRUG: Technosphere Insulin Inhalation Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebrospinal Fluid Movements Through Interventricular Foramina in Phase Contrast Magnetic Resonance Imaging (PC-MRI)
Status: COMPLETED
Conditions: CSF Circulation Disorder|Foramen; Monro, Obstruction|Mri
Interventions: DEVICE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Sit Less, Interact and Move More (SLIMM) 2 Study
Status: RECRUITING
Conditions: Chronic Kidney Diseases|Obesity
Interventions: BEHAVIORAL: SLIMM|BEHAVIORAL: Standard Resistance Training|BEHAVIORAL: Guided Resistance Training|DRUG: Placebo|DRUG: Semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of Family vs. Individually Focused Diabetes Education and Support
Status: COMPLETED
Conditions: Diabetes Mellitus|High Blood Pressure|High Blood Sugar|Hypertension
Interventions: BEHAVIORAL: FAM ACT|BEHAVIORAL: I-DSMES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Chemoradiotherapy Versus Biomarker-Guided Therapy for Elderly and Frail GBM Patients
Status: RECRUITING
Conditions: Glioblastoma Multiforme
Interventions: OTHER: Biomarker based treatment (Temozolomide monotherapy or Radiotherapy monotherapy)|COMBINATION_PRODUCT: Chemo-Radiotherapy consisting of 40 Gy in 15 daily fractions with concurrent temozolomide.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interactions Between Attentional Networks and Their Influence on Perception
Status: COMPLETED
Conditions: Hemispatial Neglect
Interventions: DEVICE: Transcranial magnetic stimulation (TMS)|DEVICE: Sham coil stimulation|OTHER: Control without stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ability of Changes in Analgesia Nociception Index to Assess the Stroke Volume Effects of a Volume Expansion of 250ml of Crystalloid in the Operating Room
Status: COMPLETED
Conditions: Volume Expansion|Fluid Responsiveness
Interventions: DEVICE: Analgesia Nociception Index (ANI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Droxidopa Treatment in Adults With Attention Deficit Hyperactivity Disorder With Co-administration of Carbidopa
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Droxidopa+Carbidopa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab and ADI-PEG 20 Before Surgery for the Treatment of Resectable Liver Cancer
Status: WITHDRAWN
Conditions: Resectable Hepatocellular Carcinoma
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: Pegargiminase|PROCEDURE: Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT