pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Targeted Memory Reactivation During REM Sleep in Patients With Social Anxiety Disorder
Status: COMPLETED
Conditions: Social Anxiety Disorder|Sleep
Interventions: BEHAVIORAL: Exposure Therapy and Targeted memory reactivation during REM sleep|BEHAVIORAL: Exposure Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ambulatory Continuous Adductor Canal Block to Facilitate Same Day Discharge Following Total Knee Arthroplasty: A Pilot Study
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Adductor canal block
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: POstoperative Negative-pressure Incision Therapy Following LIver TRANSplant:a Randomized Controlled Trial
Status: UNKNOWN
Conditions: Liver Transplant; Complications
Interventions: DEVICE: Negative-pressure wound therapy (PICO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Efficacy and Safety of Proso Millet and Wheat Extract(Keranat™) on Hair Health
Status: COMPLETED
Conditions: Hair Damage
Interventions: DIETARY_SUPPLEMENT: Keranat™|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Esophageal Damage Protection During Pulmonary Vein Ablation. Pilot Study.
Status: UNKNOWN
Conditions: Atrial Fibrillation|Catheter Ablation|Esophageal Fistula|Esophageal Diseases|Arrhythmias, Cardiac
Interventions: DEVICE: EnsoETM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rivaroxaban as Thrombosis Prophylaxis in Bariatric Surgery
Status: COMPLETED
Conditions: Bariatric Surgery
Interventions: DRUG: Rivaroxaban 10 MG Oral Tablet [Xarelto]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Biodistribution Study With 186 Re-labelled Humanised Monoclonal Antibody BIWA 4 in Patients With Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: hMAb BIWA 4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of SH1573 Capsules in Subjects With Refractory or Relapsed Acute Myelogenous Leukemia
Status: UNKNOWN
Conditions: Acute Myelogenous Leukemia
Interventions: DRUG: SH1573 Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Epidural Steroid for Controlling Pain After Primary TKA
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: epidural triamsinolone|DRUG: epidural lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of PG2 on Fatigue-Related Symptom Clusters
Status: COMPLETED
Conditions: Cancer-related Fatigue
Interventions: DRUG: Astragalus Polysaccharides 500 mg|DRUG: Astragalus Polysaccharides 250 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Systemic Lupus Erythematosus and Chlordecone Impregnation in Martinique
Status: NOT_YET_RECRUITING
Conditions: Systemic Lupus Erythematosus|Renal Disease
Interventions: OTHER: Blood sample for analysis of plasma of organochlorine pesticides concentration|OTHER: Blood sample for cell collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Autologous Stem Cell Transplant for Crohn's Disease
Status: RECRUITING
Conditions: Crohn Disease
Interventions: PROCEDURE: Autologous stem cell transplant|DRUG: Cyclophosphamide|DRUG: Cyclophosphamide|DRUG: Thymoglobulin|DRUG: Methylprednisolone|DRUG: Vedolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Luteal Phase Estradiol Support for In Vitro Fertilization/Intracytoplasmic Sperm Injection Cycles
Status: UNKNOWN
Conditions: IVF
Interventions: DRUG: 17-beta estradiol|DRUG: Micronized progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The The Effect of Planned Behavior Theory-Based Education on Physical Activity and Dysmenorrhea
Status: NOT_YET_RECRUITING
Conditions: Dysmenorrhea Primary
Interventions: BEHAVIORAL: Theory of Planned Behavior Based Training Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Effect of Two Types of Fluid in the Recovery From Anaesthesia. Voluven 6% v Hartmanns
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: OTHER: fluid administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Can we Help People With the Oral Allergy Syndrome Eat Fresh Fruit?
Status: UNKNOWN
Conditions: Oral Allergy Syndrome
Interventions: BIOLOGICAL: Allergovit Birch pollen|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Effect on 24-hour, Intragastric pH of RAB ER 50-mg Capsules Compared With Esomeprazole (Nexium) 40 mg Capsules and Rabeprazole (Aciphex) 20-mg Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: E3810|DRUG: Aciphex (rabeprazole)|DRUG: Nexium (esomeprazole)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Control for Intrauterine Device Placement: A Trial of Ketorolac Prior to Intrauterine Device Placement
Status: COMPLETED
Conditions: Pain Control With IUD Insertion
Interventions: DRUG: Ketorolac|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Phase II Study of Cisplatin and Etoposide in Combination With Either Hedgehog Inhibitor GDC-0449 or IGF-1R MOAB IMC-A12 for Patients With Extensive Stage
Status: COMPLETED
Conditions: Extensive Stage Small Cell Lung Carcinoma|Recurrent Small Cell Lung Carcinoma
Interventions: DRUG: Cisplatin|BIOLOGICAL: Cixutumumab|DRUG: Etoposide|OTHER: Laboratory Biomarker Analysis|DRUG: Vismodegib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluciclovine F18 or Ga68-PSMA PET/CT to Enhance Prostate Cancer Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Adenocarcinoma
Interventions: PROCEDURE: Computed Tomography|DRUG: Fluciclovine F18|RADIATION: Gallium Ga68-labeled PSMA-11|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Orelabrutinib With R-CHOP-like Regimen for Patients With Newly Diagnosed Untreated Non-GCB DLBCL
Status: RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Orelabrutinib|BIOLOGICAL: Rituximab|DRUG: CHOP-like Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioimpedance and Sensorimotor Effects of Percutaneous Electrolysis Protocols on the Patellar Tendon
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: High-intensity and short-duration|OTHER: Low-intensity and long-duration|OTHER: High-intensity, short-duration and 20 Hz|OTHER: Sham electrolysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of HR011408 at Two Formulations in Healthy Subject
Status: UNKNOWN
Conditions: Diabetes in Adults
Interventions: DRUG: HR011408 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NGAL and Renal Resistive Index in the Diagnosis and Prognosis of Sepsis-associated AKI
Status: COMPLETED
Conditions: Sepsis|Acute Kidney Injury
Interventions: DIAGNOSTIC_TEST: neutrophil gelatinase-associated lipocalin|DIAGNOSTIC_TEST: renal resistive index
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Topotecan Plus Cisplatin Versus Etoposide Plus Cisplatin In 1st Line Extensive Disease Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer, Small Cell
Interventions: DRUG: Intravenous topotecan/cisplatin|DRUG: Intravenous etoposide/cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LSD to Improve Cluster Headache Impact Trial
Status: NOT_YET_RECRUITING
Conditions: Chronic Cluster Headache
Interventions: DRUG: LSD tartrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Glucose and Saline for Fetal Movement Perception
Status: UNKNOWN
Conditions: Fetal Movement Perception
Interventions: DRUG: IV glucose 5%|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intestinal Colonization in Newborn Infants With Enterostomy
Status: UNKNOWN
Conditions: Newborn Infants With Enterostomy by Congenital Malformations of the Gastrointestinal Tract, Necrotizing Enterocolitis and Spontaneous Intestinal Perforation
Interventions: PROCEDURE: Exposure(s) of interest: enterostomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase IV Randomization to On-Going Treatment to Evaluate Sustained Sorafenib
Status: TERMINATED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Nexavar (Sorafenib, BAY43-9006) with addition of gemcitabine or interferon|DRUG: Gemcitabine or Interferon (only)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Clinical Study of Severe Hemophilia B Treatment With KL001
Status: NOT_YET_RECRUITING
Conditions: Hemophilia B Without Inhibitor
Interventions: DRUG: Low dose KL001|DRUG: Middle dose KL001|DRUG: High dose KL001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Nano-Bio Fusion Gel on Palatal Wound Healing After Free Gingival Graft Harvest.
Status: RECRUITING
Conditions: Free Gingival Graft
Interventions: DRUG: Nano-bio fusion gingival gel|DEVICE: stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S0425 Oxaliplatin, Capecitabine, and RT in Treating Patients W/Stomach Cancer That Can Be Removed By Surgery
Status: TERMINATED
Conditions: Gastric Cancer
Interventions: DRUG: capecitabine|DRUG: oxaliplatin|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder
Status: RECRUITING
Conditions: Alcohol Use Disorder
Interventions: OTHER: Detoxification Program|RADIATION: PKAB|RADIATION: CFN
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Aerosolized Amikacin and Fosfomycin in Mechanically Ventilated Patients With Gram-negative and / or Gram-positive Bacterial Colonization
Status: WITHDRAWN
Conditions: Pneumonia, Bacterial
Interventions: DRUG: Amikacin Fosfomycin Inhalation Solution|DRUG: Aerosolized placebo|DRUG: Amikacin Fosfomycin Inhalation Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Aripiprazole in the Treatment of Serious Behavioral Problems in Children and Adolescents With Autistic Disorder (AD)
Status: COMPLETED
Conditions: Autistic Disorder|Behavioral Symptoms
Interventions: DRUG: Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of HS135 in Obese Patients with Pulmonary Hypertension and Heart Failure with Preserved Ejection Fraction
Status: NOT_YET_RECRUITING
Conditions: Heart Failure with Preserved Ejection Fraction|Pulmonary Hypertension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Yellow Pea Fractions and Short-term Food Intake, Subjective Appetite and Glycemic Response
Status: COMPLETED
Conditions: Obesity|Type II Diabetes Mellitus|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: yellow pea protein|OTHER: yellow pea fiber|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Post-marketing Surveillance of the Negative Pressure Sleep Therapy System to Treat Obstructive Sleep Apnea
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea (OSA)
Interventions: DEVICE: iNAP® Sleep Therapy System (iNAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BSSPlus Versus Lactated Ringer's for Phacoemulsification
Status: COMPLETED
Conditions: Cataract
Interventions: PROCEDURE: Phacoemulsification|DRUG: BSSPlus solution|DRUG: Lactated Ringer's solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Creatine Monohydrate Supplementation and Vascular Endothelial Health
Status: COMPLETED
Conditions: Endothelial Dysfunction|Oxidative Stress
Interventions: DIETARY_SUPPLEMENT: Creatine monohydrate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of a Recombinant Humanized mAb Specific to B-and T-Lymphocyte Attenuator (BTLA) for Injection in Subjects With Advanced Malignancies
Status: UNKNOWN
Conditions: Advanced Solid Tumor
Interventions: BIOLOGICAL: Drug: JS004, Recombinant humanized IgG4κ monoclonal antibody specific to BTLA for injection Intravenous infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Efficacy of the G-stream® Drug-Eluting Stent in the Above-the-Knee Femoropopliteal Artery
Status: RECRUITING
Conditions: Peripheral Artery Disease
Interventions: DEVICE: Drug eluting stent|DEVICE: drug coating balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Three ACTs for the Treatment of Falciparum Malaria in Maradi Niger
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Artesunate-amodiaquine|DRUG: Dihydroartemisinin-piperaquine|DRUG: Artemether-lumefantrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implantation of Mesenchymal Stem Cell, Conditioned Medium, or Triamcinolone Acetonide for Keloid
Status: UNKNOWN
Conditions: Keloid
Interventions: BIOLOGICAL: Umbilical Cord-Mesenchymal Stem Cells and Conditioned Medium|BIOLOGICAL: Conditioned Medium|BIOLOGICAL: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myofascial Points Treatment With Focused Extracorporeal Shock Waves (ESW)
Status: COMPLETED
Conditions: Plantar Fasciitis|Myofascial Trigger Point Pain|Foot Injury
Interventions: DEVICE: Lower limb myofascial trigger points f-ESWT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Auricular Acupuncture and Cognitive Behavioral Therapy Treatment for Insomnia
Status: COMPLETED
Conditions: Insomnia|Quality of Life
Interventions: OTHER: Auricular acupuncture (AA)|OTHER: cognitive behavioral therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Exercise and Education in Patients With Chronic Pain After Total Knee Replacement
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee|Chronic Pain
Interventions: OTHER: Neuromuscular exercises (NEMEX-TJR) and pain neuroscience education|OTHER: Pain neuroscience education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine-ketamine in Femur Proximal Fracture Patients
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Dexmedetomidine|DRUG: Fentanyl|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Investigate the Effects of RIST4721 on the Inflammatory Response in Healthy Male Subjects Using a Blister Model
Status: COMPLETED
Conditions: Inflammatory Response
Interventions: DRUG: RIST4721|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Oral Bedtime Melatonin in Critically Ill Patients
Status: NOT_YET_RECRUITING
Conditions: Septic Shock|Stroke Hemorrhagic|Strokes Thrombotic|Cardiac Arrest
Interventions: DRUG: Oral Bedtime Melatonin|DRUG: Placebo suspension or capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short-term Disulfiram Administration to Accelerate the Decay of the HIV Reservoir in Antiretroviral-treated HIV Infected Individuals
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Disulfiram
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Use of Hypertonic Saline After Damage Control Laparotomy to Improve Early Primary Fascial Closure
Status: UNKNOWN
Conditions: Open Abdomen After Damage Control Laparotomy
Interventions: PROCEDURE: Primary Fascial Closure|DEVICE: wound vac dressing application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial to Assess the Effects of Topical Lotions on Changes in the Skin Microbiome and Associations With Itch
Status: COMPLETED
Conditions: Microbiota
Interventions: DRUG: OTC Eczema Moisturizer Regimen|OTHER: Cosmetic Moisturizer Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Metabolomics of Thyroid Hormones
Status: COMPLETED
Conditions: Central Hypothyroidism|Hypothyroidism|Hyperthyroidism
Interventions: DIAGNOSTIC_TEST: Indirect calorimetry|DIAGNOSTIC_TEST: Dual energy X-ray Absorptiometry (DXA)|DIAGNOSTIC_TEST: Blood sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup)
Status: COMPLETED
Conditions: Mental Disorder Diagnosed in Childhood|Obsessive Compulsive Disorder|Streptococcal Infection|Tic Disorder
Interventions: DRUG: Penicillin or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Cosmetic Outcome Study of Lid Laceration Repair With Suture Versus Tissue Adhesive
Status: TERMINATED
Conditions: Eyelid Laceration
Interventions: PROCEDURE: Tissue Adhesive skin closure|PROCEDURE: Absorbable suture skin closure|PROCEDURE: Non-absorbable suture skin closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease
Status: RECRUITING
Conditions: Sickle Cell Disease
Interventions: DRUG: Defibrotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autoimmunity-blocking Antibody for Tolerance in Recently Diagnosed Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: BIOLOGICAL: Anti-CD3 mAb|OTHER: Diabetes Standard of Care Treatment|DIETARY_SUPPLEMENT: Iron supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Performance Evaluation of Malaria Plus Rapid Diagnostic Tests (RDTs) for the Detection of Plasmodium Infections in Patients With Symptoms Suggestive of Malaria
Status: COMPLETED
Conditions: Malaria
Interventions: DIAGNOSTIC_TEST: NxTekTM Malaria Pf Plus Rapid Diagnostic Test Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Examining the Effect of the Nicotine Patch in Male and Female Smokers - 3
Status: COMPLETED
Conditions: Drug Addiction|Smoking Cessation
Interventions: DRUG: nicotine transdermal system|DRUG: Nicotine transdermal system|OTHER: Nicotine containing cigarette|OTHER: Placebo cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Critical Illness|Wounds and Injury|Disease Attributes|Pathologic Processes
Interventions: OTHER: Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate TNG348 Alone and With a PARP Inhibitor in Patients With BRCA 1/2 Mutant or HRD+ Solid Tumors
Status: TERMINATED
Conditions: Breast Cancer|Ovarian Cancer|Pancreas Cancer|Prostate Cancer|BRCA1 Mutation|BRCA-Mutated Ovarian Carcinoma|BRCA-Associated Breast Carcinoma|HRD Positive Advanced Ovarian Cancer
Interventions: DRUG: TNG348|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 12-Week Placebo-controlled Study of Atogepant for the Preventive Treatment of Migraine in Participants With Episodic Migraine
Status: COMPLETED
Conditions: Episodic Migraine
Interventions: DRUG: Atogepant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Serial Third Trimester Abdominal Circumference and Amniotic Fluid Measurements Versus Routine Care
Status: TERMINATED
Conditions: Fetal Growth Abnormality|Amniotic Fluid; Disorder
Interventions: DIAGNOSTIC_TEST: Point-of-care ultrasound (POC-US)|DIAGNOSTIC_TEST: Routine antenatal care|DIAGNOSTIC_TEST: Formal ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nitrate Modulates Cognitive Impairment Via Oral Microbiota.
Status: RECRUITING
Conditions: Microtia|Alcohol Dependence
Interventions: DIETARY_SUPPLEMENT: nitrate-rich beetroot juice|DIETARY_SUPPLEMENT: nitrate-depleted beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of PULSAR-ICI +/- IMSA101 in Patients With Oligoprogressive Solid Tumor Malignancies
Status: RECRUITING
Conditions: Oligoprogressive
Interventions: DRUG: IMSA101|DRUG: Immune checkpoint inhibitor|RADIATION: PULSAR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intramuscular Ketamine Effect on Postnasal Surgery Agitation
Status: COMPLETED
Conditions: Agitation, Emergence
Interventions: DRUG: Ketamine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Probiotic Supplementation in Hypertensive Women on Menopause
Status: UNKNOWN
Conditions: Systemic Arterial Hypertension|Menopause|Dysbiosis|Autonomic Nervous System Imbalance
Interventions: DIETARY_SUPPLEMENT: Probiotic supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Testing of the Addition of a New Anti-cancer Drug, Molibresib, to Chemotherapy Treatment (Etoposide and Cisplatin) for Patients With NUT Carcinoma
Status: WITHDRAWN
Conditions: Metastatic NUT Carcinoma|Unresectable NUT Carcinoma
Interventions: DRUG: Cisplatin|DRUG: Etoposide|DRUG: Etoposide Phosphate|DRUG: Molibresib|DRUG: Molibresib Besylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-Based Trauma Recovery for Refugees (MBTR-R)
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic|Stress Related Disorder
Interventions: BEHAVIORAL: Mindfulness-Based Trauma Recovery for Refugees (MBTR-R)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy and Safety of E-101 Solution for Preventing Surgical Site Infections After Colorectal Surgery
Status: COMPLETED
Conditions: Infections
Interventions: DRUG: E-101 Solution 300 GU/ml|DRUG: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: New Generation mRNA Booster Vaccine Against Emerging VOCs
Status: RECRUITING
Conditions: Immunogenicity|Efficacy|Safety
Interventions: BIOLOGICAL: SW-BIC-213|BIOLOGICAL: SARS-Cov-2 Vaccina(Vero Cell ) Inactivated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Dupilumab in Chinese Adult Patients With Moderate to Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Dupilumab|DRUG: Placebo|DRUG: Emollient (moisturizer)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sunitinib Malate in Treating Patients With Small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DRUG: sunitinib malate|OTHER: laboratory biomarker analysis|RADIATION: fludeoxyglucose F 18
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rectal Administration of Opioids Using the Macy Catheter in Reducing Pain in Patients With Advanced Cancer
Status: WITHDRAWN
Conditions: Advanced Malignant Neoplasm|Pain
Interventions: DEVICE: Macy Catheter|PROCEDURE: Pain Therapy|OTHER: Questionnaire Administration|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Evaluation of the Efficacy of Prophylactic Topical Gentamicin in Tunnelled Catheters for Hemodialysis
Status: COMPLETED
Conditions: Hemodialysis Catheter Infection
Interventions: DRUG: 0.1% gentamicin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Management of Hypotension In the Preterm Infant
Status: TERMINATED
Conditions: Hypotension|Low Blood Pressure|Intraventricular Hemorrhage of Prematurity
Interventions: DRUG: Dopamine hydrochloride|DRUG: Dextrose 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Therapeutic Cancer Vaccine (AST-201, pUMVC3-hIGFBP-2) in Patients With Advanced Ovarian Cancer
Status: NOT_YET_RECRUITING
Conditions: Advanced Ovarian Cancer
Interventions: BIOLOGICAL: AST-201|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Placebo|DRUG: rhuGM-CSF(Granulocyte-Macrophage Colony-Stimulating Factor)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Knowledge of Living Will in Patients With Rheumatic Diseases
Status: RECRUITING
Conditions: Rheumatic Disorder
Interventions: OTHER: Health Assessment Questionnaire (HAQ)|OTHER: Depression, Anxiety and Stress Scale (DASS-21)|OTHER: Brief Resilient Coping Scale|OTHER: WHOQOL-BREF|OTHER: Routine assessment of patient index data 3 (RAPID-3)|OTHER: Rheumatic disease comorbidity index|OTHER: Living will questionnaire|OTHER: Perceptions of Health Outcomes Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Evaluation of the Effect of 970 nm Diode Laser With or Without N Acetyl Cysteine on Post Operative Pain After Endodontic Treatment in Teeth With Symptomatic Apical Periodontiti
Status: NOT_YET_RECRUITING
Conditions: Evaluation of Post Endodontic Pain
Interventions: DRUG: N acetyle cystiene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term, Prospective Study Evaluating Clinical and Molecular Biomarkers of Epileptogenesis in a Genetic Model of Epilepsy - Tuberous Sclerosis Complex
Status: UNKNOWN
Conditions: TSC|Tuberous Sclerosis Complex|Epilepsy
Interventions: DEVICE: epilepsy early diagnosis protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Intubating Video Stylet Versus Fiberoptic Intubating Bronchoscope.
Status: COMPLETED
Conditions: Intubating Video Stylet
Interventions: DEVICE: video stylet|DEVICE: fiberoptic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Implementing an IPTS Treatment Approach to Improve Outcomes in Suicidal Youth
Status: COMPLETED
Conditions: Suicidal Ideation|Depression
Interventions: BEHAVIORAL: SPARC B|BEHAVIORAL: SPARC A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of PD-L1 Antibody ZKAB001（Drug Code） in Recurrent or Metastatic Cervical Cancer
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: DRUG: ZKAB001 5mg/kg|DRUG: ZKAB001 10mg/kg|DRUG: ZKAB001 15mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: How Does a Synbiotic Supplement Affect Iron Status During Iron Repletion in Iron Depleted Female Athletes?
Status: COMPLETED
Conditions: Iron-deficiency
Interventions: DIETARY_SUPPLEMENT: Synbiotic Supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of NeuroVax™, a Therapeutic TCR Peptide Vaccine for SPMS of Multiple Sclerosis
Status: UNKNOWN
Conditions: Secondary Progress Multiple Sclerosis|Multiple Sclerosis
Interventions: BIOLOGICAL: NeuroVax|BIOLOGICAL: IFA Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Virtual Reality During Office Hysteroscopy and Endometrial Biopsy in Subfertility
Status: COMPLETED
Conditions: Infertility, Female
Interventions: DEVICE: Oncomfort, commercially available Virtual Reality headset
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ranibizumab In Pigment Epithelium Tears Secondary To Age-Related Macular Degeneration Study
Status: COMPLETED
Conditions: Age Related Macular Degeneration
Interventions: DRUG: Ranibizumab (Lucentis, Novartis Pharma GmbH, Germany)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nicotine Pharmacokinetic Study of Heated Tobacco and Heated Herbal Products
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: OTHER: Pulze device with heated tobacco sticks (Product A)|OTHER: Pulze device with heated tobacco sticks (Product B)|OTHER: Pulze device with nicotine-infused heated herbal sticks (Product C)|OTHER: Pulze device with nicotine-infused heated herbal sticks (Product D)|OTHER: Conventional Cigarette (Product E)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery
Status: UNKNOWN
Conditions: Arteriovenous Malformation
Interventions: DRUG: Sufentanil|DRUG: dexmedetomidine 1|DRUG: dexmedetomidine 2|DRUG: dexmedetomidine 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Proof-of-Concept Study of a Selective p38 MAPK Alpha Inhibitor, Neflamapimod, in Subjects With Mild Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: neflamapimod|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Distribution of Bupropion and Varenicline to Increase Smoking Cessation Attempts
Status: COMPLETED
Conditions: Tobacco Use Disorder|Smoking|Smoking Cessation
Interventions: DRUG: bupropion|DRUG: varenicline|BEHAVIORAL: motivational emails
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thalamic Recordings in Children Undergoing SEEG
Status: NOT_YET_RECRUITING
Conditions: Focal Epilepsy
Interventions: PROCEDURE: Additional electrodes into bilateral anterior, centromedian and pulvinar thalamic nuclei
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of a Preoperative Education in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Osteoarthritis (Knee OA)
Interventions: OTHER: Kruskal-Wallis and qualitative parameters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of CEP-33457 in Participants With Systemic Lupus Erythematosus (SLE)
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: CEP-33457|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Functional Evaluation of Ceramic Onlay Restorations With Different Preparation Designs
Status: UNKNOWN
Conditions: Posterior Ceramic Onlays|Badly Decayed Teeth Need to be Restored , Teeth Restored With Large Filling Restorations
Interventions: OTHER: ceramic onlay with shoulder preparation design.|OTHER: ,ceramic onlay with butt joint preparation design
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Efficacy of an Eye-tracking-based Treatment in Reducing Stress-related Symptoms in Veterans With PTSD
Status: RECRUITING
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Gaze-Contingent Feedback Training|BEHAVIORAL: Attention Bias Modification|BEHAVIORAL: Non-Contingent Feedback Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Developing a Mobile-based Interactive Simulation Scheme for Assisting the Personalized Hands-on Learning of Nasogastric Tube Insertion
Status: COMPLETED
Conditions: Nasogastric Tube Insertion
Interventions: OTHER: A mobile-based interactive simulation scheme (MISS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Trial of Autologous Intravitreal Bone-marrow CD34+ Stem Cells for Retinopathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-exudative Age-related Macular Degeneration|Diabetic Retinopathy|Retina Vein Occlusion|Retinitis Pigmentosa|Hereditary Macular Degeneration
Interventions: DRUG: CD34+ bone marrow stem cells intravitreal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect on Cognition of Terminating ECT Induced Seizures With Propofol
Status: COMPLETED
Conditions: Major Depression
Interventions: PROCEDURE: electroconvulsive therapy|PROCEDURE: electroconvulsive therapy plus propofol|DRUG: propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Renal Function After Stentgraft Treatment Of Abdominal Aortic Aneurysm
Status: RECRUITING
Conditions: Aortic Aneurysm, Abdominal|Renal Insufficiency|Stent-Graft Thrombosis
Interventions: DEVICE: Stentgraft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determining Optimal Cuff Volume in Pediatric Patients
Status: COMPLETED
Conditions: Cuff|Airway Edema|Children, Only|Tracheal Intubation Morbidity
Interventions: OTHER: Group I (The patients intubated with cuffed ETT of ID number 4.5)|OTHER: Group II (The patients intubated with cuffed ETT of ID number 5.0)|OTHER: Group III ( The patients intubated with cuffed ETT of ID number 5.5)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Epidemiology and Prevention of Congenital HCMV in Immune Mothers. Congenital HCMV Infection Lombardy
Status: UNKNOWN
Conditions: Congenital Cytomegalovirus Infection|Maternal Cytomegalovirus Infection
Interventions: BEHAVIORAL: Hygienic recommendations
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Zetomipzomib (KZR-616) in Patients With Autoimmune Hepatitis (PORTOLA)
Status: ACTIVE_NOT_RECRUITING
Conditions: Autoimmune Hepatitis
Interventions: DRUG: zetomipzomib|DRUG: placebo|DRUG: zetomipzomib in open-label extension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Two Different Surgical Techniques for Breast Reconstruction
Status: WITHDRAWN
Conditions: Breast Reconstruction
Interventions: PROCEDURE: Prepectoral Prosthetic Breast Reconstruction|PROCEDURE: Subpectoral Prosthetic Breast Reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 30Gy Versus 40Gy Involved-field Radiotherapy for Localized Diffuse Large B Cell Lymphoma Achieving CR After Chemotherapy
Status: UNKNOWN
Conditions: Lymphoma, Large B-Cell, Diffuse
Interventions: RADIATION: 3D-CRT based Involved Field Radiotherapy|RADIATION: 3D-CRT based Involved Field Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Comparison of Postoperative Pain After Colon Resection in Intravenous Patient-controlled Analgesia Between Conventional Mode and Optimizing B.I Mode With 'PAINSTOP' Equipment
Status: COMPLETED
Conditions: Colon Cancer
Interventions: OTHER: Optimizing B.I (New) PCA mode|OTHER: Conventional PCA mode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Promoting Mental Health of Teachers and Caregiver Using a Personalized mHealth Toolkit in Uganda
Status: NOT_YET_RECRUITING
Conditions: Mental Health Literacy|Depression, Anxiety
Interventions: BEHAVIORAL: mHealth Toolkit for Wellness & Empowering Lives of School Community (mWEL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Desogestrel Versus GnRH Antagonist in IVF/ICSI
Status: UNKNOWN
Conditions: IVF|Infertility
Interventions: DRUG: Desogestrel 0.075 MG|DRUG: Orgalutran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Plus Paclitaxel in Treating Patients With Advanced Non-small Cell Lung Cancer or Other Solid Tumor
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina
Status: COMPLETED
Conditions: Angina Pectoris|Coronary Artery Disease|Type 2 Diabetes Mellitus
Interventions: DRUG: Ranolazine|DRUG: Ranolazine placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Different Modes of (S) Ketamine Administration in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: (S)-ketamine Oral Thin Film|DRUG: (S)-ketamine IV Infusion|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Double-Blind Placebo Controlled Study To Determine the Optimal Immunopharmacological Dose Level of Isoprinosine in Immunodepressed Volunteers
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Inosine pranobex
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness, Tolerability and Safety of Three Formulations in Underfives With Moderate Acute Malnutrition
Status: UNKNOWN
Conditions: Malnutrition; Moderate
Interventions: DIETARY_SUPPLEMENT: Standardized milk-based formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunologic Profile of Chronically Photodamaged Skin
Status: RECRUITING
Conditions: Photoaged Skin|Normal Skin
Interventions: BIOLOGICAL: Candida albicans antigen|BIOLOGICAL: histamine phosphate|BIOLOGICAL: imiquimod 5% cream|PROCEDURE: Tape Stripping
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Evidence-based Approach for Bullying Prevention
Status: UNKNOWN
Conditions: Bullying|Cyberbullying|Substance Use|Substance Abuse
Interventions: BEHAVIORAL: LST MS curriculum+ Bullying/Cyberbulling serious game|BEHAVIORAL: LST MS curriculum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of OMS103HP in Patients Undergoing Allograft Anterior Cruciate Ligament (ACL) Reconstruction
Status: COMPLETED
Conditions: Knee Injuries
Interventions: DRUG: OMS103HP|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT