pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety, Tolerability, and Pharmacokinetics of CSX-1004
Status: COMPLETED
Conditions: Opioid Overdose|Opioid Use Disorder
Interventions: BIOLOGICAL: CSX-1004|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Prucalopride (Resolor®) on Gastric Motor Function and Gastric Sensitivity
Status: COMPLETED
Conditions: Gastrointestinal Motility Disorder|Dyspepsia
Interventions: DRUG: Prucalopride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: rTMS in Improving Neuropathy in Patients With Stage I-IV Cancer Who Have Received Oxaliplatin Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Neoplasm|Neuropathy
Interventions: OTHER: Best Practice|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Repetitive Transcranial Magnetic Stimulation|PROCEDURE: Sham Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impacts of Intermittent Fasting on Energy Balance and Associated Health Outcomes
Status: COMPLETED
Conditions: Obesity|Type 2 Diabetes
Interventions: DEVICE: Physical Activity Monitoring (Actiheart)|OTHER: Energy Intake Monitoring|OTHER: Body Weight Monitoring|PROCEDURE: Intravenous Cannulation|PROCEDURE: Adipose Tissue Biopsy|DRUG: Lidocaine Hydrochloride|OTHER: Post-Prandial Meal Tests|RADIATION: DEXA Scan|OTHER: Actiheart Calibration|OTHER: Daily Calorie Restriction|OTHER: Intermittent Fasting with Weight Loss|OTHER: Intermittent Fasting without Weight Loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remimazolam Improves the Safety in Elderly Patients Undergoing Gastrointestinal Endoscopy
Status: UNKNOWN
Conditions: Anesthetics|Recovery|Drug Effect|Safety|Psychotropic Drugs|Anesthetics, Intravenous
Interventions: DRUG: Remimazolam|DRUG: Propofol group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Avastin (Bevacizumab) in Combination With mFOLFOX-6 or FOLFOXIRI in Patients With Metastatic Colorectal Cancer.
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: 5-FU|DRUG: 5-FU|DRUG: 5-FU|DRUG: Irinotecan|DRUG: Leucovorin|DRUG: Leucovorin|DRUG: Oxaliplatin|DRUG: bevacizumab [Avastin]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Longitudinal QoL in Patients Undergoing EEA
Status: RECRUITING
Conditions: Pituitary Tumor|Meningioma|Rathke Cleft Cysts|Chordoma|Chondrosarcoma|Craniopharyngioma|Encephalocele|Esthesioneuroblastoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Improvement of Quality of Life of Patients Suffering From Hailey Hailey or Darier Disease After Injections of Botulism Toxin Into Large Folds.
Status: COMPLETED
Conditions: Hailey-Hailey Disease|Darier Disease
Interventions: DRUG: Botulism Toxin Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Isatuximab and Bendamustine in Systemic Light Chain Amyloidosis
Status: WITHDRAWN
Conditions: Amyloidosis|Light Chain (AL) Amyloidosis
Interventions: DRUG: Bendamustine Hydrochloride|DRUG: Isatuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biological Characterisation of High Risk CHildhood Cancer in Children, Adolescents and Young Adults (MICCHADO)
Status: RECRUITING
Conditions: Neuroblastoma|Rhabdomyosarcoma|Ewing Sarcoma Family of Tumors|Osteosarcoma|Leukemia|Central Nervous System Tumor
Interventions: OTHER: Sampling on blood, bone marrow and cerebrospinal fluid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function
Status: COMPLETED
Conditions: Cardiovascular Diseases|Heart Diseases|Heart Failure, Congestive
Interventions: DRUG: Spironolactone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Calcium Metabolism in Caucasian and Asian Postmenopausal Women of Chinese Descent and the Use of Strontium as a Qualitative Marker of Calcium Metabolism
Status: COMPLETED
Conditions: Calcium Metabolism
Interventions: OTHER: Ca-41(isotope tracer)|OTHER: Sr-84 (isotope tracer)|DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial of Polypodium Leucotomos in Preventing Skin Cancer and Its Precursors
Status: WITHDRAWN
Conditions: Keratosis, Actinic|Keratosis|Skin Neoplasms
Interventions: DRUG: Heliocare with Fernblock PLE technology|OTHER: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Investigate Safety and Clinical Activity of Belantamab Mafodotin in Combination With Lenalidomide, Dexamethasone and Nirogacestat in Patients With Transplant Ineligible Newly Diagnosed Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma|Neoplasms|Neoplasm, Plasma Cell|Gammopathy, Monoclonal|Paraproteinemias|Blood Protein Disorders|Haematologic Disease|Corneal Disease
Interventions: DRUG: Belantamab Mafodotin-Blmf|DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: Nirogacestat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Mometasone to Reduce Painful Episodes in Patients With Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: Mometasone Furoate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arthroscopic Rotator Cuff Repair With Platelet-Rich Plasma(PRP) in Large to Massive Tears
Status: COMPLETED
Conditions: Rotator Cuff Tear
Interventions: PROCEDURE: Conventional arthroscopic rotator cuff repair|PROCEDURE: Arthroscopic rotator cuff repair with PRP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Supplementation With 25-hydroxyvitamin D3 in Older Adults
Status: COMPLETED
Conditions: Vitamin D Status as Reflected by Serum 25-hydroxyvitamin D
Interventions: DIETARY_SUPPLEMENT: vitamin D3|DIETARY_SUPPLEMENT: 25-hydroxyvitamin D3|DIETARY_SUPPLEMENT: 25-hydroxyvitamin D (20 microgram/day)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: GSK3640254 200 mg|DRUG: Caffeine 200 mg|DRUG: Metoprolol 100 mg|DRUG: Montelukast 10 mg|DRUG: Flurbiprofen 100 mg|DRUG: Omeprazole 40 mg|DRUG: Midazolam 5 mg (2.5 mL)|DRUG: Digoxin 0.25 mg|DRUG: Pravastatin 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Hair Regrowth Efficacy and Safety of ALRV5XR in Female Subjects With Hair Loss
Status: COMPLETED
Conditions: Androgenetic Alopecia|Androgenic Alopecia|Telogen Effluvium|Thinning Hair|Hair Loss/Baldness|Hair Thinning
Interventions: DIETARY_SUPPLEMENT: ALRV5XR|OTHER: ALRV5XR Shampoo|OTHER: ALRV5XR Conditioner|OTHER: ALRV5XR Hair Follicle Serum (Nutriment)|DIETARY_SUPPLEMENT: Placebo|OTHER: Placebo Shampoo|OTHER: Placebo Conditioner|OTHER: Placebo Hair Follicle Serum (Nutriment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Apixaban for the Prevention of Thrombosis-related Events in Patients With Acute Medical Illness
Status: COMPLETED
Conditions: Venous Thrombosis|Pulmonary Embolism
Interventions: DRUG: Apixaban|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Fit for Function: A Community Wellness Program for Persons With Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: BEHAVIORAL: Community Based Exercise Program|OTHER: Living with Stroke Education program|OTHER: YMCA membership
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Liposomal Irinotecan in Combination With Oxaliplatin, Leucovorin, and 5-fluorouracil for Patients With Locally Advanced Pancreatic Carcinoma:
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Pancreatic Carcinoma(LAPC)
Interventions: DRUG: FOLFOX regimen|DRUG: Liposomal Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Position on Gastric Residual Volume and Comfort Level in Newborns
Status: COMPLETED
Conditions: Comfort|Newborn, Infant, Disease|Position|Residual
Interventions: BEHAVIORAL: Supine position|BEHAVIORAL: Prone position|BEHAVIORAL: Lateral position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I Open Label Study of E7974 Administered on a Day 1 of 21-Day Cycle In Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Cancer, Malignant Tumors
Interventions: DRUG: E7974
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Anesthesia for Removal of Stitches After Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Metal Staple Removal After Total Knee Replacement
Interventions: DRUG: Lidocaine patch|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Evaluating Dosing Regimens for Treatment With Intravitreal Ranibizumab Injections in Subjects With Macular Edema Following Retinal Vein Occlusion
Status: COMPLETED
Conditions: Macular Edema
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Effectiveness of Galantamine in Patients With Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease|Dementia|Mental Disorders|Brain Diseases
Interventions: DRUG: galantamine hydrobromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Resuscitative Endocrinology: Single-dose Clinical Uses for Estrogen-Traumatic Hemorrhagic Shock (RESCUE - Shock)
Status: COMPLETED
Conditions: Hemorrhagic Shock
Interventions: DRUG: Premarin IV|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Dose-finding Study of Oral Applied Hexaminolevulinate (HAL) Imaging in Patients With Suspicion or High Risk of Neoplasia in the Colon
Status: TERMINATED
Conditions: Colon Cancer
Interventions: DRUG: hexaminolevulinate HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dexmedetomidine Infusion and Postoperative Lung Aeration After Thoracic Surgery
Status: RECRUITING
Conditions: Surgery-Complications|Respiratory Complication|Lung Injury, Acute
Interventions: DRUG: Dexmedetomidine Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erythropoietin for Management of Anemia Caused by Chemotherapy
Status: COMPLETED
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: Darbepoetin alfa|DRUG: R-CHOP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Double and Single Intrauterine Insemination In Controlled Ovarian Stimulation (COH) Cycles With Multifollicular Development
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: Intrauterine insemination (single)|PROCEDURE: Double intrauterine insemination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of CC-95251 in Participants With Acute Myeloid Leukemia and Myelodysplastic Syndromes
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia, Myeloid, Acute|Myelodysplastic Syndromes
Interventions: DRUG: CC-95251|DRUG: Azacitidine|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SLIM: Combined Effects of Slo-Niacin and Atorvastatin on Lipoproteins and Inflammatory Markers in Hyperlipidemia
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: Slo-Niacin, atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of Two Surgical Blades
Status: UNKNOWN
Conditions: Wound Healing
Interventions: PROCEDURE: connective tissue graft harvest using KPM blade|PROCEDURE: connective tissue graft harvest using 15 C blade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prospective Study to Determine Impact of Early Palliative Care Consult on Quality of Life (QOL), Cancer Related Symptoms In Advanced Lung Cancer Patients: Thoracic Pilot Project
Status: COMPLETED
Conditions: Lung Cancer|Non-small Cell Lung Cancer
Interventions: BEHAVIORAL: QOL Questionnaire|BEHAVIORAL: Caregiver Satisfaction Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Eversion in Dermatologic Surgery: Is Cosmetic Appearance Improved?
Status: COMPLETED
Conditions: Basal Cell Carcinoma|Squamous Cell Carcinoma|Melanoma
Interventions: PROCEDURE: Everted suture technique|PROCEDURE: Non-everted suture technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cetuximab Combined With Irinotecan in First-line Therapy for Metastatic Colorectal Cancer (CRYSTAL)
Status: COMPLETED
Conditions: Epidermal Growth Factor Receptor (EGFR) Expressing Metastatic Colorectal Cancer
Interventions: DRUG: Cetuximab|DRUG: FOLFIRI (5-Fluorouracil, Folinic acid, Irinotecan)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Safety of the Viscoelastic Substance PRO-149 When Used During Phacoemulsification, Compared to Healon® EndoCoat.
Status: COMPLETED
Conditions: Age-related Cataract|Phacoemulsification
Interventions: DEVICE: Sodium hyaluronate 3%|DEVICE: Sodium hyaluronate 3%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Commuter Air Pollution Intervention Study
Status: COMPLETED
Conditions: Cognitive Function|Cardiopulmonary Function|Saliva Stress Hormones|Air Pollution Exposure|Lung Inflammation
Interventions: DEVICE: Cabin Air Filtration|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Haloperidol vs. Metoclopramide for Treatment of Acute Headaches and Migraines in the Emergency Department
Status: TERMINATED
Conditions: Headache, Migraine
Interventions: DRUG: Metoclopramide|DRUG: Haloperidol|OTHER: Normal Saline|DRUG: Diphenhydramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Better Adherence With New Oral Anticoagulant in Atrial Fibrillation : Effectiveness of a Personalized Education Program
Status: COMPLETED
Conditions: Non-valvular Atrial Fibrillation
Interventions: DRUG: Xarelto|OTHER: Experimental: Personalized information intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Determination of Levels of Micafungin in Neonates Suffering From Systemic Candidiasis and/or Candida Meningitis
Status: COMPLETED
Conditions: Candidiasis, Systemic|Candida Meningitis
Interventions: DRUG: Micafungin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development Of Neuroimaging Methods To Assess The Neurobiology Of Addiction
Status: RECRUITING
Conditions: Normal Physiology
Interventions: OTHER: In vivo MRS|OTHER: fMRI|OTHER: EEG/EOG|OTHER: Stimulation tasks|OTHER: NSPRD|OTHER: Structural MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase I-II Everolimus and Sorafenib in Recurrent High-Grade Gliomas
Status: COMPLETED
Conditions: Brain Tumor|Glioblastoma|Anaplastic Glioma
Interventions: DRUG: everolimus|DRUG: sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of the Mechanism of Synergism Between FP and Salmeterol in Preventing COPD Exacerbations
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: fluticasone and salmeterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of CDX-1307, hCG-B Vaccine, for Patients With Incurable, Locally Advanced or Metastatic Breast, Colorectal, Pancreatic, Bladder or Ovarian Cancer
Status: COMPLETED
Conditions: Breast Cancer|Colorectal Cancer|Pancreatic Cancer|Bladder Cancer|Ovarian Cancer
Interventions: BIOLOGICAL: CDX-1307
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pseudophakic Cystoid Macular Lesions After Uncomplicated Standard Phacoemulsification
Status: COMPLETED
Conditions: Pseudophakic Cystoid Macular Lesions After Uncomplicated Standard Phacoemulsification
Interventions: DRUG: topical bromfenac sodium hydrate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Differences in Epicardial Plaque and Microvascular Function in Women With an Acute Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: PROCEDURE: IVUS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessing Continuous Glucose Monitors in Healthy Children
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: Continuous Glucose Monitoring System (CGMS)|DEVICE: GlucoWatch G2TM Biographer (GW2B)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Stem Cell Transplant to Treat Limbus Insufficiency Syndrome
Status: COMPLETED
Conditions: Limbus Corneae Insufficiency Syndrome
Interventions: PROCEDURE: Stem Cell with Amniotic Membrane Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Atorvastatin as an Antihypertensive Agent
Status: COMPLETED
Conditions: Atorvastatin Antihypertensive Effect
Interventions: DRUG: Amlodipine 5 MG Oral Tablet|DRUG: Amlodipine 5 MG / Atorvastatin 10 MG Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Morbidity During Post-Acute Care Transitions for Sepsis
Status: COMPLETED
Conditions: Clinical Sepsis
Interventions: BEHAVIORAL: Sepsis Transition And Recovery (STAR)|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intima-Medial Thickness Guidance of Primary Prevention in Relatives of Patients With Early onSet Atherosclerosis
Status: UNKNOWN
Conditions: Atherosclerotic Cardiovascular Disease|Cardiovascular Disease
Interventions: BEHAVIORAL: IMPRESS intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study To Investigate The Safety And Efficacy Of CP- 690,550 In Patients With Moderate And Severe Ulcerative Colitis.
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: CP- 690 550|DRUG: CP- 690 550|DRUG: CP- 690 550|DRUG: CP- 690 550|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Nintedanib in the Treatment of Pulmonary Fibrosis in Patients With Moderate to Severe COVID -19
Status: UNKNOWN
Conditions: COVID-19|Nintedanib|Safety|Effect of Drugs
Interventions: DRUG: Nintedanib 150 MG|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Conversion Study to Assess Safety and Efficacy of a MR4 Based Immunosuppressive Regimen in Stable Liver Recipients
Status: COMPLETED
Conditions: Transplantation
Interventions: DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Handgrip Strength Value in Predicting Mechanical Ventilation Weaning
Status: COMPLETED
Conditions: Ventilator Weaning|Hand Strength|Respiration
Interventions: PROCEDURE: Handheld dynamometry (handgrip strength)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Eccentric Exercise Training as Novel Rehabilitation for Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|Bronchitis, Chronic|Emphysema
Interventions: OTHER: Eccentric exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Vyvanse Compared to Concerta in Adolescents With Attention-deficit/Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention-deficit/Hyperactivity Disorder
Interventions: DRUG: Lisdexamfetamine dimesylate|DRUG: Methylphenidate Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PALLiON - PALLiative Care In ONcology
Status: COMPLETED
Conditions: Neoplasia Prostate
Interventions: OTHER: Educational program|OTHER: Standardized care pathways|OTHER: Early palliative care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Study to Assess Next-day Driving Performance Following Administration of ACT-541468 in Middle-aged and Elderly Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ACT-541468|DRUG: Zopiclone 7.5 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of Moxidex Otic
Status: TERMINATED
Conditions: Acute Otitis Media
Interventions: DRUG: Moxidex otic solution|DRUG: Moxifloxacin otic solution|OTHER: Vehicle|DEVICE: Tympanostomy tubes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: EYTO (European Youth Tackling Obesity): A Randomized Controlled Trial in Catalonia (Spain)
Status: COMPLETED
Conditions: Obesity|Life Style
Interventions: BEHAVIORAL: Social marketing activities and pop-up events to promote healthy lifestyles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Interventional Cooperative Agreement Program - Vocational Intervention Demonstration
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injuries|Brain Injuries|Employment|Spinal Cord Diseases
Interventions: OTHER: State Counselor-Coordinated Services|OTHER: Center Facilitator-Coordinated Services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Nicotine Effects on Endophenotypes of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Transdermal nicotine patch|DRUG: Placebo patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess the Bioequivalence Between D961S and Esomeprazole/Buffered Acetylsalicylic Acid (ASA) in Japanese Healthy Male Subjects
Status: COMPLETED
Conditions: Bioequivalence Study
Interventions: DRUG: D961S|DRUG: Esomeprazole|DRUG: Buffered acetylsalicylic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fecal Microbiota Transplantation (FMT) in Metastatic Melanoma Patients Who Failed Immunotherapy
Status: UNKNOWN
Conditions: Melanoma Stage Iv|Unresectable Stage III Melanoma
Interventions: PROCEDURE: Fecal Microbiota Transplant (FMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MIDAS Cluster Randomized Controlled Trial of Implementation Strategies to Optimize Use of Medications in VA Clinical Settings
Status: COMPLETED
Conditions: Polypharmacy|Insomnia|Anticoagulants
Interventions: BEHAVIORAL: Academic Detailing (AD)|BEHAVIORAL: LEAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Switching Efavirenz to Raltegravir on Vascular Function and Bone Markers in HIV-infected Patients
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Tenofovir/emtricitabine|DRUG: Tenofovir/emtricitabine/efavirenz|DRUG: Raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging of Retinochoroidal Vasculature in Patients Being Assessed for Cardiovascular Disease
Status: RECRUITING
Conditions: Cardiovascular Diseases|Retina; Change
Interventions: DIAGNOSTIC_TEST: Swept Source Optical Coherence Tomography Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Niraparib and Neratinib in Advanced Solid Tumors With Expansion Cohort in Advanced Ovarian Cancer
Status: RECRUITING
Conditions: Advanced Solid Tumor|Ovarian Cancer
Interventions: DRUG: Neratinib 160 mg|DRUG: Neratinib 200 mg|DRUG: Neratinib 240 mg|DRUG: Niraparib 100 mg|DRUG: Niraparib 200 mg|DRUG: Niraparib 300 mg|DRUG: Niraparib at RP2D|DRUG: Neratinib at RP2D
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison And Outcomes Of Fluid Resucitation With 0.9% Normal Saline And 5% Albumin In Cirrhosis Patients With Sepsis Induced Hypotension
Status: COMPLETED
Conditions: Cirrhosis With Septic Shock
Interventions: DRUG: 5% albumin Infusion|DRUG: 0.9% sodium chloride solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Two Silicone Hydrogel Daily Disposable Contact Lenses
Status: COMPLETED
Conditions: Vision Disorders
Interventions: DEVICE: JJVC Marketed Contact Lens (Test)|DEVICE: Competitor Marketed Contact Lens (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers of iNOS Activity in COPD, Asthma, Healthy Control
Status: WITHDRAWN
Conditions: Healthy Smokers|Healthy Non-smokers|Patients With Mild Asthma|Patints With COPD (GOLD II)
Interventions: PROCEDURE: Induced Sputum|PROCEDURE: Exhaled Nitric Oxide|PROCEDURE: Nasal Nitric Oxide|PROCEDURE: Blood Tests|PROCEDURE: 24hr Urine Samples|PROCEDURE: Exhaled Breath Condensate|PROCEDURE: Spirometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enzalutamide With Lu PSMA-617 Versus Enzalutamide Alone in Men With Metastatic Castration-resistant Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Castration-Resistant Prostate Cancer
Interventions: DRUG: Lu-PSMA|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids
Status: RECRUITING
Conditions: Glioblastoma|Brain Tumor|Cannabis|Brain Tumor, Recurrent
Interventions: DRUG: Nabiximols|DRUG: Temozolomide|DRUG: Nabiximols-matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Senofilcon A Toric Lenses to Balafilcon A Toric Lenses Over Extended Wear Period
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: senofilcon A toric contact lens|DEVICE: balafilcon A toric contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of Autologous Cardiopoietic Cells for Treatment of Ischemic Heart Failure.
Status: COMPLETED
Conditions: Heart Failure
Interventions: BIOLOGICAL: Injection of C3BS-CQR-1|BIOLOGICAL: Sham, no injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Role of the Induced Membrane in the Reconstruction of Bone Loss in the Limbs
Status: RECRUITING
Conditions: Bone Loss
Interventions: BIOLOGICAL: Blood sample collection|BIOLOGICAL: Other biological sample collection|DIAGNOSTIC_TEST: Surgical waste collection|DIAGNOSTIC_TEST: Radiological examination and functional exploration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Characterizing and Predicting Drug Effects on Cognition
Status: COMPLETED
Conditions: Cognitive Deficits
Interventions: DRUG: Lorazepam|OTHER: Placebo|DRUG: Topiramate 100mg|DRUG: Topiramate 150mg|DRUG: Topiramate 200mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Pilot Therapeutic Trial Using Hydroxyurea in Type II and Type III Spinal Muscular Atrophy Patients
Status: COMPLETED
Conditions: Muscular Atrophy, Spinal
Interventions: DRUG: Hydroxyurea|DRUG: Placebo to match hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Implantation in Patients Undergoing CABG
Status: TERMINATED
Conditions: Ischemic Cardiomyopathy|Coronary Artery Disease
Interventions: DEVICE: Autologous CD133+ Bone Marrow Stem Cells|OTHER: Carrier Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Arginase Inhibition in Type 1 and Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes|Type 2 Diabetes
Interventions: DIAGNOSTIC_TEST: Nω-hydroxy-nor-arginine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Quick Icing (QI) Technique on Strenght of Jump.
Status: SUSPENDED
Conditions: Muscle Strength
Interventions: DEVICE: Quick icing|DEVICE: Prolonged Cold
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Minocycline-Containing Bismuth Quadruple Therapy for Helicobacter Pylori Eradication
Status: UNKNOWN
Conditions: Helicobacter Pylori Eradication
Interventions: DRUG: Minocycline hydrochloride capsule|DRUG: Clarithromycin|DRUG: Amoxicillin|DRUG: colloidal bismuth pectin|DRUG: esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proximal Roux-en-y Gastrojejunal Anastomosis on Delayed Gastric Emptying After Pylorus-resecting Pancreaticoduodenectomy
Status: UNKNOWN
Conditions: Pancreatic Cancer|Bile Duct Cancer|Duodenal Cancer
Interventions: PROCEDURE: PrPD with proximal Roux-en-y gastrojejunal anastomosis|PROCEDURE: conventional PrPD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efavirenz (EFV) in HIV-Infected and HIV/Tuberculosis (TB) Coinfected Children
Status: COMPLETED
Conditions: HIV Infections|Tuberculosis
Interventions: DRUG: Efavirenz (EFV)|DRUG: Rifampin-containing anti-TB therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperalgesia and NMDA Receptor Antagonist
Status: UNKNOWN
Conditions: Pain
Interventions: DRUG: Magnesium Sulfate|DRUG: ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of JNJ-77242113 for the Treatment of Participants With Plaque Psoriasis Involving Special Areas (Scalp, Genital, and/or Palms of the Hands and the Soles of the Feet)
Status: ACTIVE_NOT_RECRUITING
Conditions: Plaque Psoriasis
Interventions: DRUG: JNJ-77242113|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of GLP-1 Receptor Agonist on Cerebral Blood Flow Velocity in Stroke
Status: RECRUITING
Conditions: Ischemic Stroke
Interventions: DRUG: Byetta|DRUG: Normosaline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Ascending Dose Study in Adults (Stage 1) and Single Ascending Dose-Finding Study (Stage 2) in Elderly Subjects With ASP3772, A Pneumococcal Vaccine
Status: COMPLETED
Conditions: Pneumonia, Bacterial|Healthy Volunteers|Pneumococcal Disease
Interventions: BIOLOGICAL: ASP3772|BIOLOGICAL: PCV13|BIOLOGICAL: PPSV23
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Chlorhexidine-Induced Oral Care on Ventilator-Related Some Respiratory System Complications
Status: COMPLETED
Conditions: Ventilator Associated Pneumonia|Tracheobronchitis
Interventions: DRUG: 0.12% chlorhexidine gluconate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Trial to Reduce Wound Infection With Contralateral Drainage in Loop Ileostomy Closure
Status: COMPLETED
Conditions: Surgical Wound Infection
Interventions: PROCEDURE: application of a contralateral drainage (Penrose ® device)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment of an Anemia Model Predictive Controller for Anemia Management in Hemodialysis Patients
Status: UNKNOWN
Conditions: End Stage Renal Disease|Renal Anemia|Chronic Kidney Diseases
Interventions: OTHER: Anemia Controller
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders
Interventions: DRUG: Ramelteon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effects of a Cannabidiol Derived From Hemp Supplement in Healthy Adults
Status: COMPLETED
Conditions: Healthy|Safety Issues
Interventions: DIETARY_SUPPLEMENT: Cannabinol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: High Dose Ascorbic Acid (HDAA) in Patients With Plasma Cell Disorders
Status: RECRUITING
Conditions: Plasma Cell Disorder
Interventions: DRUG: 75gm HDAA|DRUG: 100gm HDAA|DRUG: 125gm HDAA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adipose-tissue-derived Total-Stromal-cells (TOST) Therapy in Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis Knees
Interventions: BIOLOGICAL: Adipose Tissue derived Total-Stromal-Cells (TOST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Phase II Study of Hyperbaric Oxygen in Improving Engraftment in Umbilical Cord Blood Stem Cell Transplant
Status: RECRUITING
Conditions: AML|NHL|Hodgkin Disease|All|Myelodysplastic Syndrome
Interventions: DRUG: Hyperbaric oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Botswana Vitamin D Supplementation Study in HIV/AIDS
Status: COMPLETED
Conditions: HIV
Interventions: DIETARY_SUPPLEMENT: 4000 IU/d D3 over 12 weeks|DIETARY_SUPPLEMENT: 7000 IU/d D3 over 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ENTact™ Septal Stapler Shelf Life Extension
Status: COMPLETED
Conditions: Deviated Nasal Septum
Interventions: DEVICE: ENTact™ Septal Stapler|DEVICE: ENTact™ Septal Stapler
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Empowerment and Mobile Technology in the Control of Cardiovascular Risk Factors in Patients With Ischemic Stroke
Status: RECRUITING
Conditions: Ischemic Stroke|Transient Ischemic Attack|Atrial Fibrillation|Hypertension|Empowerment
Interventions: DIAGNOSTIC_TEST: ECG monitoring for 3 weeks|OTHER: Self-monitoring of BP and self-titration of antihypertensive medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prophylactic Antiviral Therapy in Patients With Current or Past Hepatitis B Virus Infection Receiving Anti-Cancer Therapy for Solid Tumors
Status: TERMINATED
Conditions: Hepatitis B Infection|Malignant Solid Neoplasm
Interventions: OTHER: Best Practice|DRUG: Entecavir|DRUG: Tenofovir Alafenamide|DRUG: Tenofovir Disoproxil Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Safety and Efficacy of ASP1941 in Combination With α-glucosidase Inhibitor in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: ipragliflozin|DRUG: alpha glucosidase inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sodium Bicarbonate, Saline and Black Mulberry Syrup on Degree of Oral Mucositis in Children Receiving Chemotherapy
Status: NOT_YET_RECRUITING
Conditions: Oral Mucositis|Chemotherapy Effect
Interventions: OTHER: Sodium Bicarbonate Group (Usual care)|OTHER: Saline Group|OTHER: Black Mulberry Syrup Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: HIV/STD Risk and PrEP Implementation Messaging Among Gay, Bisexual, and Other Men Who Have Sex With Men
Status: RECRUITING
Conditions: Sexually Transmitted Infections|Gay|Pre Exposure Prophylaxis
Interventions: BEHAVIORAL: Quantitative survey|DIAGNOSTIC_TEST: HIV & STI testing|BEHAVIORAL: Qualitative Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial of the FMS-like Tyrosine Kinase 3 (FLT3) Inhibitor Gilteritinib Administered as Maintenance Therapy Following Allogeneic Transplant for Patients With FLT3/Internal Tandem Duplication (ITD) Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: gilteritinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 4 Courses vs 2 Courses of Pembrolizumab Combined With Carboplatin and Albumin-binding Paclitaxel of Neoadjuvant Therapy in HNSCC
Status: RECRUITING
Conditions: HNSCC|Oral Cancer|PD-1
Interventions: DRUG: Pembrolizumab+Carboplatin+albumin-bound paclitaxel:4 courses|DRUG: Pembrolizumab+Carboplatin+albumin-bound paclitaxel:2 courses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visual Reconstitution Therapy After Optic Neuritis
Status: COMPLETED
Conditions: Optic Neuritis|Multiple Sclerosis
Interventions: OTHER: Visual Reconstitutions Therapy|OTHER: Saccadic Eye Movement Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability Study of AVP-786 as an Adjunctive Therapy in Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatment
Status: COMPLETED
Conditions: Depressive Disorder, Treatment-Resistant
Interventions: DRUG: AVP-786 (d6-dextromethorphan hydrobromide and quinidine sulfate combination)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study for Provoked Vestibulodynia
Status: COMPLETED
Conditions: Vestibulodynia
Interventions: OTHER: Somatosensory Rehabilitation Program|OTHER: Educational Pain Management Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Classification and DISE-Guided Surgery in Pediatric Obstructive Sleep-Disordered Breathing.
Status: NOT_YET_RECRUITING
Conditions: Obstructive Sleep Apnea of Child
Interventions: DIAGNOSTIC_TEST: Drug-induced Sleep Endoscopy findings (identified obstruction sites)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Role of Sacubitril/Valsartan in the Improvement of Heart Failure With Reduced Ejection Fraction
Status: COMPLETED
Conditions: Heart Failure, Left Sided|Left Ventricular Dysfunction|Ventricular Remodeling
Interventions: DIAGNOSTIC_TEST: Role of Sacubitril/Valsartan in Hemodynamic and Echocardiographic Improvement of Heart Failure With Reduced Ejection Fraction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Inhibition of Atrial Fibrillation by Elimination of Transitional Mechanisms
Status: WITHDRAWN
Conditions: Atrial Fibrillation|Arrhythmia
Interventions: PROCEDURE: Firm ablation for transitional AF rotors
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC