pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Influence of Sequential Tau Protein and Amyloid Plaque Imaging Changes on Stroke Prognosis and Cognitive Outcome
Status: RECRUITING
Conditions: Post-stroke Dementia, Vascular Mild Cognitive Impairment
Interventions: DRUG: [18F]THK-5351|DRUG: [18F]AV-45
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: ROTEM-guided Transfusion Protocol in Attempt to Reduce Blood Transfusions in Major Oncological Surgery
Status: WITHDRAWN
Conditions: Blood Loss, Surgical|Blood Loss Requiring Transfusion|Coagulation Defect; Acquired
Interventions: DIAGNOSTIC_TEST: Rotational thromboelastometry|OTHER: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of an Amino Acids and Flavonoids Containing FSMP on Chemotherapy Toxicity, Nutritional Status and Quality of Life in Breast Cancer Patients
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DIETARY_SUPPLEMENT: FSMP|OTHER: Nutritional counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CMP-001 in Combination With Nivolumab Compared to Nivolumab Monotherapy in Subjects With Advanced Melanoma
Status: COMPLETED
Conditions: Melanoma|Advanced Melanoma|Metastatic Melanoma|Unresectable Melanoma
Interventions: DRUG: CMP-001|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nintedanib in Patients With Bronchiolitis Obliterans Syndrome Following Hematopoietic Stem Cell Transplantation
Status: RECRUITING
Conditions: Bronchiolitis Obliterans Syndrome (BOS)|Bronchiolitis Obliterans (BO)
Interventions: DRUG: Nintedanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Community Activation for Prevention (CAPs): A Study of Community Gardening
Status: UNKNOWN
Conditions: Cancer|Obesity|Lifestyle, Sedentary|Physical Activity|Health Behavior|Chronic Disease|Diet Modification
Interventions: BEHAVIORAL: Community Garden Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bifido- and Lactobacilli in Symptomatic Adult COVID-19 Outpatients
Status: COMPLETED
Conditions: COVID-19 Respiratory Infection
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rifaximin's Effect on Covert Hepatic Encephalopathy With SIBO and Gastrointestinal Dysmotility
Status: WITHDRAWN
Conditions: Cirrhosis, Liver|Minimal Hepatic Encephalopathy|Small Intestinal Bacterial Overgrowth|Gastrointestinal Motility Disorder
Interventions: DRUG: Rifaximin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of XOMA 052 in Familial Cold Autoinflammatory Syndrome / Muckle-Wells Syndrome and Behcet's Disease
Status: WITHDRAWN
Conditions: Muckle Wells Syndrome|Autoinflammatory|Behcet's Disease
Interventions: DRUG: XOMA 052
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Deep Versus Moderate Muscle Relaxants in Men During and After Robotic Surgery for Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Rocuronium 0.3mg/kg/hr|DRUG: Rocuronium 1.5mg/kg/hr
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Revlimid / All-Trans Retinoic Acid (ATRA) / Dexamethasone in Relapsed/Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Myeloma
Interventions: DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: All-Trans Retinoic Acid (ATRA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visual Quality Following Aspheric Intraocular Lens (IOL) Implantation - a Comparative Clinical Study
Status: COMPLETED
Conditions: Aphakia|Cataract
Interventions: DEVICE: Study IOL|DEVICE: Hoya iSert 751|DEVICE: Negatively aspheric IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does the Sara Combilizer®, an Early Mobilization Aid, Reduce the Time Taken to First Mobilise Ventilated Patients in Intensive Care?
Status: COMPLETED
Conditions: Critical Illness
Interventions: DEVICE: Sara Combilizer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bilateral Surgical Resection of Carotid Bodies in Patients With Systolic Heart Failure
Status: COMPLETED
Conditions: Systolic Heart Failure|Peripheral Chemoreceptor Hypersensitivity
Interventions: PROCEDURE: Bilateral Surgical Resection of Carotid Bodies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nurse Navigation Program Based On Health Belief Model In Breast Cancer Screening (NaHeB-CaS)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Nurse Navigation Program Based On Health Belief Model In Breast Cancer Screening (NaHeB-CaS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Azacitidine and Entinostat in Treating Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Recurrent Colon Cancer|Recurrent Rectal Cancer|Stage IV Colon Cancer|Stage IV Rectal Cancer
Interventions: DRUG: entinostat|DRUG: azacitidine|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of SII Yellow Fever Vaccine to Compare Safety and Immunogenicity With STAMARIL® In Healthy Infants
Status: RECRUITING
Conditions: Yellow Fever
Interventions: BIOLOGICAL: SII Yellow Fever Vaccine|BIOLOGICAL: STAMARIL®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Safety and Pharmacology of MetMAb (PRO143966), a Monovalent Antagonist Antibody to the Receptor C-Met, Administered Intravenously in Patients With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Solid Cancers
Interventions: DRUG: bevacizumab|DRUG: MetMAb|DRUG: MetMAb
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraocular Cytokines in Non-responders to Ranibizumab Treatment for Neovascular AMD
Status: COMPLETED
Conditions: Age Related Macular Degeneration
Interventions: DRUG: Aflibercept|DRUG: Ranibizumab|PROCEDURE: Combination Photodynamic Therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Efficacy of Intravenous/Oral Bondronat (Ibandronate) in Patients With Metastatic Bone Disease Experiencing Moderate to Severe Pain
Status: TERMINATED
Conditions: Pain|Bone Neoplasm|Neoplasm Metastasis
Interventions: DRUG: ibandronate [Bondronat]|DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response
Status: RECRUITING
Conditions: Chronic Low Back Pain
Interventions: OTHER: Pain EASE|PROCEDURE: Tailored exercise|OTHER: Continued Care and Active Monitoring|BEHAVIORAL: Cognitive Behavioral Therapy (CBT)|PROCEDURE: Spinal Manipulation Therapy (SMT)|PROCEDURE: Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation for Treating Parkinson´s Disease-related Pain in OFF State
Status: COMPLETED
Conditions: Parkinson Disease|Pain
Interventions: DEVICE: Active Transcranial Direct Current Stimulation|DEVICE: Sham Transcranial Direct Current Stimulation|DRUG: Dopaminergic medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modified Whey Protein and Effect on Post Meal Glucose Levels Study
Status: COMPLETED
Conditions: Metabolism Disorder, Glucose
Interventions: DIETARY_SUPPLEMENT: Control|DIETARY_SUPPLEMENT: Normal Whey protein|DIETARY_SUPPLEMENT: Modified whey protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Ameliorative Effects of GLP-1RA on Diabetic Cardiac Autonomatic Neuropathy
Status: RECRUITING
Conditions: Type 2 Diabetes|Diabetes With Diabetic Autonomic Neuropathy (Diagnosis)
Interventions: DRUG: Glucagon-like peptide-1 receptor agonist：Semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside
Status: NOT_YET_RECRUITING
Conditions: Ataxia Telangiectasia
Interventions: DRUG: Nicotinamide riboside
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Insulation Failure in St. Jude Riata Leads
Status: UNKNOWN
Conditions: Implanted With Any Currently (and Any Future) FDA-approved Medtronic ICD or CRT Device|to Which is Attached a St. Jude Riata Lead
Interventions: PROCEDURE: fluoroscopy|PROCEDURE: synchronized high-voltage shock|PROCEDURE: Holter monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effects of Inhibiting Early Inflammation in Kidney Transplant Patients
Status: COMPLETED
Conditions: Kidney Transplant
Interventions: BIOLOGICAL: Infliximab|DRUG: Methylprednisolone|DRUG: Mycophenolate Mofetil|DRUG: Tacrolimus|BIOLOGICAL: Thymoglobulin®|DRUG: Acetaminophen|DRUG: Loratadine|BIOLOGICAL: Placebo for Infliximab|DRUG: Prednisone|DRUG: Diphenhydramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Methylprednisolone Infiltration in Anserine Bursitis Treatment
Status: COMPLETED
Conditions: Bursitis
Interventions: DRUG: EXPERIMENTAL|DRUG: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Safety and Efficacy of the Addition of ABT-888 Plus Carboplatin Versus the Addition of Carboplatin to Standard Chemotherapy Versus Standard Chemotherapy in Subjects With Early Stage Triple Negative Breast Cancer
Status: COMPLETED
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Cyclophosphamide|DRUG: Placebo|DRUG: Doxorubicin|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Veliparib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Abatacept to Treat Lupus Nephritis
Status: TERMINATED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Corticosteroids (prednisone or prednisolone)|DRUG: Abatacept|DRUG: Abatacept|DRUG: Mycophenolate mofetil (MMF)|DRUG: Abatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GM-CSF Inhalation to Prevent ARDS in COVID-19 Pneumonia
Status: COMPLETED
Conditions: Severe Acute Respiratory Syndrome (SARS) Pneumonia|COVID-19 Pneumonia
Interventions: DRUG: Molgramostim nebuliser solution|OTHER: Placebo nebuliser solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ANDES-AGI-1067 as a Novel Antidiabetic Agent Evaluation Study
Status: UNKNOWN
Conditions: Diabetes
Interventions: DRUG: Placebo|DRUG: AGI-1067|DRUG: AGI-1067
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Temozolomide During and After Radiation Therapy in Treating Patients Who Have Undergone Previous Surgery and Placement of Gliadel Wafers for Newly Diagnosed Glioblastoma Multiforme
Status: TERMINATED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: temozolomide|PROCEDURE: adjuvant therapy|PROCEDURE: chemotherapy|PROCEDURE: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analysis of Early Healing of Sutures in Periodontal Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Post-Surgical Complication|Periodontal Inflammation|Surgical Site Infection
Interventions: OTHER: Periodontal Access Surgery+ Suture with chlorhexidine|OTHER: Periodontal Access Surgery+ Suture without chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Tolerability and Efficacy of Nefopam Cream in Burn Patients
Status: RECRUITING
Conditions: Burn; Multiple Body Regions, Max. Second Degree|Third-Degree Burn|Burn Degree Second
Interventions: DRUG: Nefopam|OTHER: Placebo (Vehicle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Can Vena Cava Ultrasound Guided Volume Repletion Prevent Spinal Induced Significant Hypotension in Elective Patients?
Status: COMPLETED
Conditions: Fluid Overload|Anesthesia; Adverse Effect, Spinal and Epidural|Regional Anesthesia Morbidity
Interventions: DEVICE: Ultrasound-guided volemic repletion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of GS-3K8 and GINst15 on Acute Respiratory Illness
Status: COMPLETED
Conditions: Acute Respiratory Infection
Interventions: DIETARY_SUPPLEMENT: GS-3K8|DIETARY_SUPPLEMENT: GINst15|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Outcomes of Sclerotherapy of the Ulcer Bed Compared to a Combination of Ablation and Injections
Status: RECRUITING
Conditions: Venous Reflux|Venous Insufficiency|Venous Ulcer|Venous Disease
Interventions: PROCEDURE: Polidocanol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application Of Autologous Blood Products During Modified Radical Mastectomy
Status: UNKNOWN
Conditions: Mastectomy
Interventions: PROCEDURE: Application of autologous blood products.|PROCEDURE: Standard Modified Radical Mastectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Locally Administered Morphine and Bupivicaine on Acute and Chronic Postmastectomy Pain
Status: COMPLETED
Conditions: Acute Pain|Chronic Pain
Interventions: DRUG: local instillation of morphine to surgical wound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Brief Intervention for Justice-Involved Substance Users
Status: COMPLETED
Conditions: Substance Use|Violence
Interventions: BEHAVIORAL: BMI|BEHAVIORAL: Stadard Care (SC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nondrug Treatment Programs for Adults With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: BEHAVIORAL: Behavioral coping skills training plus physical therapy|BEHAVIORAL: Stress management education plus physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Target-Controlled Infusion of Propofol for Flexible Bronchoscopy Sedation
Status: TERMINATED
Conditions: Flexible Bronchoscopy
Interventions: PROCEDURE: TCI titration by different Cet.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Lapatinib+Vinorelbine vs Vinorelbine HER2 Positive Metastatic Breast Cancer Progressed After Lapatinib/Trastuzumab
Status: UNKNOWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Lapatinib|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib Safety lead-in, Followed by Phase II Trial of ADG106 in Combination With Neoadjuvant Chemotherapy in HER2 Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: HER2-negative Breast Cancer|Advanced Solid Tumor
Interventions: DRUG: ADG106|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rizatriptan 5 mg and 10 mg, Sumatriptan 100 mg, and Placebo Comparison Study (0462-030)
Status: COMPLETED
Conditions: Migraine Headache
Interventions: DRUG: rizatriptan benzoate|DRUG: rizatriptan benzoate|DRUG: Comparator: sumatriptan|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis
Status: COMPLETED
Conditions: Ocular Toxoplasmosis
Interventions: DRUG: Trimethoprim-Sulfamethoxazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy With or Without Epirubicin in Treating Women With Stage I or Stage II Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: CMF regimen|DRUG: cyclophosphamide|DRUG: epirubicin hydrochloride|DRUG: fluorouracil|DRUG: methotrexate|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Enhancing STDP After Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: OTHER: STDP|BEHAVIORAL: Training|OTHER: Sham STDP|OTHER: Multisite-STDP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Pevonedistat Plus Azacitidine Versus Single-Agent Azacitidine in Participants With Higher-Risk Myelodysplastic Syndromes (HR MDS), Chronic Myelomonocytic Leukemia (CMML) and Low-Blast Acute Myelogenous Leukemia (AML)
Status: COMPLETED
Conditions: Myelodysplastic Syndromes|Leukemia, Myelomonocytic, Chronic|Leukemia, Myeloid, Acute
Interventions: DRUG: Azacitidine|DRUG: Pevonedistat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stepping to Understand Lower Limb Impairments in Bilateral Cerebral Palsy
Status: ACTIVE_NOT_RECRUITING
Conditions: Cerebral Palsy|Bilateral Cerebral Palsy|Diplegic Cerebral Palsy
Interventions: OTHER: load modulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fed Study of Finasteride Tablets 5 mg and Proscar® Tablets 5 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Finasteride Tablets 5 mg|DRUG: Proscar® Tablets 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Congenital Heart Disease: Impact on Learning and Development in Down Syndrome (CHILD-DS)
Status: COMPLETED
Conditions: Down Syndrome|Congenital Heart Disease
Interventions: OTHER: Stanford Binet Intelligence Scales, Fifth Edition|OTHER: Vineland Adaptive Behavior Scales Third Edition|OTHER: Peabody Picture Vocabulary Test, Fifth Edition|OTHER: Expressive Vocabulary Test, Third Edition|OTHER: Leiter International Performance Scale, Third Edition|OTHER: Social Communication Questionnaire, Current Form|OTHER: Aberrant Behavior Checklist|OTHER: Repetitive Behavior Scale, Revised
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bintrafusp Alfa (M7824) and NHS-IL12 (M9241) Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies
Status: RECRUITING
Conditions: Urothelial Cancer|Bladder Cancer|Genitourinary Cancer|Urogenital Neoplasms|Urogenital Cancer
Interventions: DRUG: M7824|DRUG: M9241|RADIATION: Stereotactic body radiation therapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed &Oxaliplatin in Patients w Recurrent NSCLCa After Failure to Platinum Based Adjuvant Chem
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DRUG: Oxaliplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of a Multicomponent Nurse Intervention to Reduce Delirium in Hospitalized Older Adults
Status: COMPLETED
Conditions: Delirium
Interventions: OTHER: Multicomponent nurse-led intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Next-Dose Transition From Zolpidem to Lemborexant (LEM) for the Treatment of Insomnia
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: LEM 5 mg|DRUG: LEM 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AcoArt Ⅱ/ BTK China: Drug-eluting Balloon for Below-The-Knee Angioplasty Evaluation in China
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: PROCEDURE: DEB catheter|PROCEDURE: common PTA balloon catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nasal Intubation Using a Parker Flex-tip Endotracheal Tube Compared to a Nasal RAE Tube
Status: COMPLETED
Conditions: Epistaxis
Interventions: DEVICE: Nasal Intubation with nasal RAE endotracheal tube|DEVICE: Nasal Intubation with Parker Flex-Tip endotracheal tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: D-Cycloserine Augmentation of Intermittent Theta Burst Stimulation (iTBS) in Depression (COGENT)
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DRUG: D-Cycloserine|DEVICE: Intermittent Theta Burst Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pharmacodynamic Equivalence of Enoxaparin Rovi to Clexane®, in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Enoxaparin|DRUG: Clexane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Codrituzumab in Children and Young Adults With Solid Tumors and Have Not Responded to Treatment or Have Come Back After Treatment
Status: RECRUITING
Conditions: Primary Extra-cranial Solid Tumor|Recurrent or Refractory Glypican 3 (GPC3)
Interventions: DRUG: Codrituzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Toric Intraocular Lens Following Cataract Surgery
Status: COMPLETED
Conditions: Cataract|Astigmatism
Interventions: DEVICE: Toric Accommodating Lens|DEVICE: Accommodating Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Bioequivalence of a Test Tablet Formulation of Metformin HCl (1000 mg), Compared to an Equivalent Dose of a Commercially Available Reference Drug Product (Glucophage®, Bristol-Myers Squibb Company) in Fasted, Healthy, Adult Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Metformin HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Paraorbital-Occipital Alternating Current Stimulation Therapy for Optic Neuropathy (MCT_optnerve)
Status: COMPLETED
Conditions: Optic Nerve Diseases|Optic Nerve Injuries|Optic Neuropathies
Interventions: DEVICE: tACS|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of CVN424 in Parkinson's Disease Patients With Motor Fluctuations
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: CVN424 Low Dose|DRUG: CVN424 High Dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intensity Modulated Radiation Therapy for Head and Neck Cancer
Status: COMPLETED
Conditions: Nasopharyngeal Neoplasms
Interventions: PROCEDURE: intensity modulated radiation therapy|DRUG: cisplatinium and fluorouracil - standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuro Anatomical Correlation of Oropharyngeal Swallowing Revisited in Cerebrovascular Stroke Patients
Status: RECRUITING
Conditions: Stroke, Acute
Interventions: DIAGNOSTIC_TEST: functional endoscopic evaluation of swallow
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Phase II Study of Cediranib (AZD2171) in Patients With Alveolar Soft Part Sarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcoma, Alveolar Soft Part
Interventions: DRUG: AZD2171
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide for Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Recurrent Nasopharyngeal Undifferentiated Carcinoma|Stage IV Nasopharyngeal Undifferentiated Carcinoma
Interventions: DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventive Arterial Wall Phenotype and Low-dose Fluvastatin/Valsartan Combination
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DRUG: fluvastatin 10 mg and valsartan 20 mg|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing "Salvage" Radiotherapy and Individualized PSMA PET/CT Targeted Treatment in With Relapsing Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: COMBINATION_PRODUCT: Individualised therapy|RADIATION: Standard salvage therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FloSeal Tubeless Exit Versus Cope Loop Nephrostomy Versus Fascial Stitch Following Percutaneous Nephrolithotripsy
Status: COMPLETED
Conditions: Kidney Calculi
Interventions: PROCEDURE: Floseal|PROCEDURE: Cope Loop|PROCEDURE: Fascial Stitch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tomato Paste Consumption on the Microbiota-gut-brain Axis in Healthy Adults
Status: RECRUITING
Conditions: Microbiota|Cognitive Function|Healthy Lifestyle
Interventions: OTHER: Intervention A - Tomato paste|OTHER: Intervention B - Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vaccine Therapy in Treating Patients With Chronic Phase Chronic Myelogenous Leukemia
Status: TERMINATED
Conditions: Leukemia
Interventions: BIOLOGICAL: bcr-abl peptide vaccine|GENETIC: reverse transcriptase-polymerase chain reaction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digitally-enhanced, Decentralized, Multi-omics Observational Cohort
Status: ENROLLING_BY_INVITATION
Conditions: Presymptomatic Disease|Mild Cognitive Impairment|Memory Loss (Excluding Dementia)|Cognitive Change|Dementia|Alzheimer Disease|Parkinson's Disease and Parkinsonism
Interventions: DIAGNOSTIC_TEST: AltoidaML
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Postoperative Pain Associated With Three Endodontic Rotary Systems
Status: UNKNOWN
Conditions: Acute Pulpitis
Interventions: DEVICE: ONE ENDO|DEVICE: F6 SKYTaper|DEVICE: ProTaper Universal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Family-Authored ICU Diaries to Reduce Fear in Patients Experiencing a Cardiac Arrest (FAID Fear)
Status: COMPLETED
Conditions: Cardiac Arrest|Post Traumatic Stress Syndrome
Interventions: BEHAVIORAL: FAID Fear Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effects of Iron and Omega-3 Fatty Acid Supplementation on Cognition and Immune Function in Iron Deficient Children
Status: COMPLETED
Conditions: Iron Deficiency|Anemia
Interventions: DIETARY_SUPPLEMENT: DHA and EPA Fish Oil capsule|DIETARY_SUPPLEMENT: Iron tablet|OTHER: Placebo tablet|OTHER: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vaginal Cleansing at Cesarean Delivery to Reduce Infection: A Randomized, Controlled Trial
Status: TERMINATED
Conditions: Cesarean Section|Endometritis|Surgical Wound Infection
Interventions: PROCEDURE: Vaginal cleansing before cesarean delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Maternal DHA Supplementation and Offspring Neurodevelopment in India (DHANI-2)
Status: COMPLETED
Conditions: Pregnancy
Interventions: DIETARY_SUPPLEMENT: Docosa Hexaenoic Acid (DHA)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Psychometric Properties of Adapted Turkish Version of ISYQOL Questionnaire in Patients With AIS
Status: COMPLETED
Conditions: Adolescent Idiopathic Scoliosis|Health Related Quality of Life
Interventions: OTHER: Turkish Version of The Italian Spine Youth Quality of Life (ISYQOL) Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: His-bundle Pacing vs. Right Ventricular Apical Pacing in Patients With Reduced Ejection Fraction
Status: RECRUITING
Conditions: His Bundle Pacing|Heart Failure, Systolic
Interventions: DEVICE: His-bundle pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development and Evaluation of a Tonic Immobility Focused Psychoeducational Intervention
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder|Tonic Immobility Response
Interventions: BEHAVIORAL: Tonic Immobility Psychoeducation (TIP)|BEHAVIORAL: Health Education Training (HET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Immune Effects of Oral Insulin in Relatives at Risk for Type 1 Diabetes Mellitus (TN20)
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: 67.5 mg oral insulin crystals daily|DRUG: 500mg oral insulin crystals every other week
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Psychosocial Therapy and Risperidone Treatment in Work Performance in Recent-Onset Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Cognitive remediation training (CT)|BEHAVIORAL: Healthy behavior training (HBT)|DRUG: Risperidone, administered orally (Oral Ris)|DRUG: Risperidone, administered via injection (RLAI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of AKCEA-ANGPTL3-LRX (ISIS 703802) in Patients With Homozygous Familial Hypercholesterolemia (HoFH)
Status: WITHDRAWN
Conditions: Homozygous Familial Hypercholesterolemia
Interventions: DRUG: AKCEA-ANGPTL3-LRX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nilotinib in Newly Diagnosed Adult Philadelphia Chromosome & /or BCR-ABL Positive Chronic Myeloid Leukaemia in Chronic Phase
Status: COMPLETED
Conditions: CML in Chronic Phase
Interventions: DRUG: Nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iltamiocel Compared to Placebo for Chronic Fecal Incontinence in Females With Obstetric Injury
Status: RECRUITING
Conditions: Fecal Incontinence
Interventions: BIOLOGICAL: Iltamiocel|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nicotinic Receptors and Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: DMXB-A-SR|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed Plus Gemcitabine as Front-Line Chemotherapy for Patients With Malignant Pleural or Peritoneal Mesothelioma
Status: COMPLETED
Conditions: Mesothelioma
Interventions: DRUG: Pemetrexed|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Dose Escalation Study of SN2310 Injectable Emulsion in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Breast Neoplasms|Colorectal Neoplasms|Pancreatic Neoplasms|Pelvic Neoplasms|Lung Neoplasms
Interventions: DRUG: SN2310 Injectable Emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Equivalence Among Antiepileptic Drug Generic and Brand Products in People With Epilepsy: Chronic-Dose 4-Period Replicate Design
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Lamotrigine Generic "A"|DRUG: Lamotrigine generic "B"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MRD-directed Therapy for Low-risk and Intermediate-risk AML.
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Minimal Residual Disease
Interventions: COMBINATION_PRODUCT: MRD-directed therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety and Efficacy of Neuroprotective Peptide CN-105 Peptide in Patients With Acute Supratentorial Intracerebral Hemorrhage
Status: RECRUITING
Conditions: Intracerebral Hemorrhage
Interventions: DRUG: CN-105
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Dexamethasone Versus Dexamethasone Combined With Rituximab in Patients With Newly Diagnosed Idiopathic Thrombocytopenic Purpura (ITP)
Status: COMPLETED
Conditions: Idiopathic Thrombocytopenic Purpura
Interventions: DRUG: Dexamethasone|DRUG: Dexamethasone and Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of 1072nm Infrared Stimulation on Executive Functioning in Dementia
Status: COMPLETED
Conditions: Dementia
Interventions: DEVICE: 1072nm infrared Photobiomodulation|DEVICE: Photobiomodulation SIMULATED
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rasagiline in Advanced Parkinson's Disease Patients With Motor Fluctuations Treated With Levodopa/Carbidopa Therapy.
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: rasagiline mesylate|DRUG: rasagiline mesylate 1.0 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Armodafinil (CEP-10953) in Treatment of Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea (OSA/H) Syndrome
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Sleep Hypopnea
Interventions: DRUG: Armodafinil 150 mg/day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Metformin for the Treatment of Unexplained Oligozspermia
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: Metformin / clomid / hCG|DRUG: Clomiphene citrate / hCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of SOR-C13 in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Malignant Solid Neoplasm|Refractory Malignant Solid Neoplasm|Refractory Ovarian Carcinoma|Refractory Pancreatic Carcinoma|Stage II Pancreatic Cancer AJCC v8|Stage IIA Pancreatic Cancer AJCC v8|Stage IIB Pancreatic Cancer AJCC v8|Stage III Ovarian Cancer AJCC v8|Stage III Pancreatic Cancer AJCC v8|Stage III Prostate Cancer AJCC v8|Stage IIIA Ovarian Cancer AJCC v8|Stage IIIA Prostate Cancer AJCC v8|Stage IIIB Ovarian Cancer AJCC v8|Stage IIIB Prostate Cancer AJCC v8|Stage IIIC Ovarian Cancer AJCC v8|Stage IIIC Prostate Cancer AJCC v8|Stage IV Ovarian Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8|Stage IV Prostate Cancer AJCC v8|Stage IVA Ovarian Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8|Stage IVB Ovarian Cancer AJCC v8|Stage IVB Prostate Cancer AJCC v8
Interventions: DRUG: TRPV6 Calcium Channel Inhibitor SOR-C13
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of ZT-01 on Glucagon During Hypoglycemia in Type 1 Diabetes Mellitus
Status: TERMINATED
Conditions: Type 1 Diabetes|Hypoglycemia
Interventions: DRUG: ZT-01 low dose|DRUG: ZT-01 high dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Extension Study to Assess Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD)
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: Vamorolone 0.25 mg/day/day|DRUG: Vamorolone 0.75 mg/day/day|DRUG: Vamorolone 2.0 mg/day/day|DRUG: Vamorolone 6.0 mg/day/day
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: This Study in Healthy Volunteers Determines the Amount of BI 730460 in the Blood When Taken as Tablet. It Looks at How Different Doses of BI 730460 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Tests How Food Influences the Amount of BI 730460 in the Blood.
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: BI 730460|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Studying Melatonin and Recovery in Teens
Status: RECRUITING
Conditions: Juvenile; Scoliosis|Scoliosis Idiopathic|Scoliosis; Adolescence|Scoliosis;Congenital|Kyphosis|Spondylolisthesis|Pectus Surgery|Hip Surgery
Interventions: DIETARY_SUPPLEMENT: Fast-Dissolve Melatonin Pill|OTHER: Fast-Dissolve Placebo Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Stool Transplantation for Treatment of Insulin Resistance in Morbidly Obese Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity, Morbid|Insulin Resistance
Interventions: BIOLOGICAL: Fecal filtrate from 150 g stool from healthy lean donors|BIOLOGICAL: Fecal filtrate from 150 g of the recipient's own stool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MRI and PET/FMISO In Assessing Tumor Hypoxia in Patients With Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma
Interventions: DRUG: FMISO|OTHER: MRI|OTHER: PET|OTHER: MRS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Identification of Serum and/or Plasma Biomarkers for the Diagnosis Prognosis and/or Prediction of Invasive Mycosis in Neutropenic Patients
Status: COMPLETED
Conditions: Neutropenic Patients
Interventions: OTHER: Samples taken at the clinical hematology unit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Edentulous Sites Augmented With Collagen Matrix or CTG
Status: RECRUITING
Conditions: Edentulous Alveolar Ridge
Interventions: PROCEDURE: Soft tissue augmentation with subepithelial connective tissue graft (SCTG)|PROCEDURE: Soft tissue augmentation with xenogenic volume stable collagen matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of REGN3500 and Dupilumab in Patients With Asthma
Status: COMPLETED
Conditions: Asthma, Allergic
Interventions: DRUG: REGN3500|DRUG: Dupilumab|DRUG: Placebo|DRUG: Fluticasone propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Aronia Melanocarpa Extract on Cognitive Function
Status: COMPLETED
Conditions: Cognitive Function
Interventions: DIETARY_SUPPLEMENT: Aronia|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Indoor Air Quality Monitoring and Impact on Children's Health
Status: RECRUITING
Conditions: Cognition
Interventions: DEVICE: OurAir SQ 1750 - Mobile Air Purification System for indoor|DEVICE: Sham intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Full Anticoagulation Versus Prophylaxis in COVID-19: COALIZAO ACTION Trial
Status: COMPLETED
Conditions: Coronavirus Infection
Interventions: DRUG: Group 1: Rivaroxaban 20mg/d followed by enoxaparin/unfractionated heparin when needed|DRUG: Group 2: control group with enoxaparin 40mg/d
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gamma Knife Radiosurgery vs Initial Conservative Treatment for Vestibular Schwannoma Patients With Preserved Hearing, a Prospective Randomized Study
Status: COMPLETED
Conditions: Vestibular Schwannoma
Interventions: RADIATION: Initial Gamma knife radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT