pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Low-intensity Cognitive-behavioural Therapy for Insomnia
Status: COMPLETED
Conditions: Insomnia
Interventions: BEHAVIORAL: Cognitive behavioural therapy for insomnia|BEHAVIORAL: Sleep hygiene education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Implementing Nurse-performed Ultrasound-guided Peripheral Intravenous Access in Oncology Patients
Status: NOT_YET_RECRUITING
Conditions: Supportive Care
Interventions: DEVICE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Coronary Computed Tomography Angiography For Optimized Invasive Coronary examInation
Status: RECRUITING
Conditions: Ischemic Heart Disease|Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: CCTA guided focused coronary angiography examination.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution Once Daily and Twice Daily in Subjects With Primary Open-Angle Glaucoma SPECTRUM 6
Status: COMPLETED
Conditions: Primary Open-angle Glaucoma and Ocular Hypertension
Interventions: DRUG: DE-117 Ophthalmic Solution QD|DRUG: DE-117 Ophthalmic Solution BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Uniportal Versus Triportal Thoracoscopic Lobectomy and Sublobectomy for Early Stage Lung Cancer
Status: UNKNOWN
Conditions: Lung Neoplasms
Interventions: PROCEDURE: Triportal pulmonary resection surgery|PROCEDURE: Uniportal pulmonary resection surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Diagnosis of Intracranial Infection After Craniotomy
Status: UNKNOWN
Conditions: Intracranial; Infection, Psychosis, Acute or Subacute
Interventions: DIAGNOSTIC_TEST: postoperative fever, serum procalcitonin, C-reactive protein and white blood cell coun
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Investigate the Effect of Food, Gender, and Age on the Pharmacokinetic Profile of SUVN-G3031 in Healthy Subjects
Status: COMPLETED
Conditions: Cognitive Disorders
Interventions: DRUG: SUVN-G3031
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess the Influence of Aronox on Parameters Associated With Aerobic Performance
Status: COMPLETED
Conditions: Aerobic Capacity
Interventions: DIETARY_SUPPLEMENT: 500mg of Aronox® >40% polyphenol aronia extract|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Silver Diamine Fluoride(SDF) Versus SDF Combined With Sodium Fluoride Varnish in the Arrest of Early Childhood Caries
Status: COMPLETED
Conditions: Early Childhood Caries
Interventions: DEVICE: SDF|DEVICE: NaF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Comparing Continuous Infusion Antibiotics to Standard Treatment for Lung Infections in Cystic Fibrosis
Status: UNKNOWN
Conditions: Cystic Fibrosis
Interventions: DRUG: Intermittent, short infusion Ceftazidime|DRUG: Continuous infusion Ceftazidime|DRUG: Intermittent, short infusion Meropenem|DRUG: Continuous infusion Meropenem|DRUG: Intermittent, short infusion Ticarcillin-clavulanate|DRUG: Continuous infusion Ticarcillin-clavulanate|DRUG: Intermittent, short infusion Cefepime|DRUG: Continuous infusion Cefepime|DRUG: Continuous infusion Piperacillin tazobactam|DRUG: Intermittent, short infusion Piperacillin tazobactam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CT-guided Needle Guidance Using Stereotaxic Unit, Navigation Versus Conventional Biopsy Technique for the Percutaneous Pulmonary Nodule Biopsy
Status: UNKNOWN
Conditions: Percutaneous Pulmonary Nodule Biopsy
Interventions: DEVICE: stereotaxic unit, navigation|DEVICE: conventional biopsy technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: IBS Titan™ Sirolimus-eluting Iron Bioresorbable Peripheral Scaffold System Clinical Trial
Status: RECRUITING
Conditions: Infrapopliteal Lesions|Critical Limb Ischemia
Interventions: DEVICE: Sirolimus-eluting Iron Bioresorbable Peripheral Scaffold System (IBS Titan™)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Staged Phase 3 Study to Assess the Safety and Immunogenicity of Ebola Candidate Vaccines Ad26.ZEBOV and MVA-BN-Filo
Status: COMPLETED
Conditions: Ebola Virus Disease
Interventions: BIOLOGICAL: Ad26.ZEBOV|BIOLOGICAL: MVA-BN-Filo|BIOLOGICAL: MenACWY|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Voriconazole Inhalation Powder for the Treatment of Pulmonary Aspergillosis
Status: AVAILABLE
Conditions: Invasive Pulmonary Aspergillosis|Allergic Bronchopulmonary Aspergillosis|Chronic Pulmonary Aspergillosis|Aspergillus Tracheobronchitis|Anastomotic Infection|Pulmonary Fungal Infection
Interventions: DRUG: Voriconazole Inhalation Powder
Study Type: EXPANDED_ACCESS
Clinical trial: Impact of Coronary Artery Stenting on Quantitative Myocardial Blood Flow and Health Status
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Rubidium-82|BEHAVIORAL: Seattle Angina Questionnaire-7|BEHAVIORAL: Rose Dyspnea Scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluate PF-00547659 On Cerebrospinal Fluid Lymphocytes In Volunteers With Crohn's Disease Or Ulcerative Colitis Who Failed Or Did Not Tolerate Anti-TNFs
Status: COMPLETED
Conditions: Crohn's Disease|Ileitis|Ileo-colonic and Colonic Crohn's Disease|Granulomatous Colitis|Regional Enteritis|Ulcerative Colitis
Interventions: PROCEDURE: lumbar puncture|DRUG: lumbar puncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Wavefront-guided Photorefractive Keratectomy (PRK) Versus Wavefront-guided Lasik for Myopia
Status: COMPLETED
Conditions: Myopia|Astigmatism
Interventions: PROCEDURE: Photorefractive keratectomy|PROCEDURE: Laser in-situ keratomileusis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Micro RNAs to Predict Response to Androgen Deprivation Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Bicalutamide|DRUG: Leuprolide|DRUG: Goserelin|DRUG: Triptorelin|DRUG: Docetaxel|DRUG: Abiraterone|DRUG: Apalutamide|DRUG: Enzalutamide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Predictive Value of PIIINP Urinary for the Development of Chronic Renal Failure in Patients With Cystic Fibrosis After Lung Transplantation (MUCO-IRC)
Status: TERMINATED
Conditions: Lung Transplantation|Cystic Fibrosis|Renal Failure
Interventions: BIOLOGICAL: Urinary levels of PIIINP as a marker of changes in renal function
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of First-Line Gemcitabine Chemotherapy in GemCore+ Metastatic Pancreatic Adenocarcinoma Patients
Status: NOT_YET_RECRUITING
Conditions: Cancer Of Pancreas
Interventions: OTHER: Analyze of GemCore status
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Intraoperative Radiotherapy for Rectal Cancer Using the Photon Radiosurgery System
Status: TERMINATED
Conditions: Rectal Neoplasm
Interventions: RADIATION: Photon Radiosurgery System IORT|RADIATION: Photon Radiosurgery System IORT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Test-guided Tailored Therapy Versus Empiric Treatment for Helicobacter Pylori Infection.
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection|Antibiotic Resistant Infection|Antibiotic Resistant Strain
Interventions: DRUG: Pantoprazole 40mg|DRUG: Amoxicillin 1000 MG|DRUG: Clarithromycin 500mg|DRUG: Metronidazole|DRUG: Tetracycline 125 MG|DRUG: Bismuth Subcitrate|DRUG: Rifabutin 150 MG|DRUG: Levofloxacin 500mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DIabetic Retinopathy Candesartan Trials
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: candesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Arthroscopic Partial Meniscectomy(APM)
Status: RECRUITING
Conditions: Meniscus Tear
Interventions: PROCEDURE: early APM|PROCEDURE: delayed APM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Study to Evaluate Intranasal Dose of STI-2099 (COVI-DROPS™) in Outpatient Adults With Mild COVID-19 Infection
Status: WITHDRAWN
Conditions: COVID-19
Interventions: BIOLOGICAL: COVI-DROPS|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is in Vitro Maturation of Oocytes Influenced by the Origin of Gonadotropins Used in Maturation Medium: is There a Difference in Efficiency When Using Urinary Versus Recombinant Produced Follicle Stimulating Hormone and Human Chorionic Gonadotropin
Status: UNKNOWN
Conditions: In Vitro Maturation of Oocytes
Interventions: DRUG: rhCG= Ovitrelle®, 250g/0.5ml = 26000IU/ml, Merck-Serono|DRUG: rFSH = Gonal F®, 300IU/0.5ml, Merck-Serono
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bowman-Birk Inhibitor Concentrate in Healthy Men
Status: COMPLETED
Conditions: Healthy, no Evidence of Disease
Interventions: DRUG: Bowman-Birk inhibitor concentrate|OTHER: placebo|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Applications of Fluorescence Imaging Guided Lymph Node Dissection and Fluorescence Angiography of Inferior Mesenteric Artery Assisted Left Colic Artery Preservation
Status: RECRUITING
Conditions: Fluorescence|Indocyanine Green|Rectal Cancer Surgery
Interventions: DEVICE: Fluorescence laparoscopic system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Vasodilators on Coronary No-reflow During primAry percuTaneous Coronary intErvention in Patients With Acute Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction|Percutaneous Coronary Intervention
Interventions: DRUG: Diltiazem|DRUG: Verapamil|DRUG: Nitroglycerin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of AMG 706 Plus Panitumumab Plus Chemotherapy in the Treatment of Subjects With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer|Colon Cancer
Interventions: DRUG: FOLFOX-4|DRUG: AMG 706|BIOLOGICAL: Panitumumab (Part 1a only)|DRUG: FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identifying the Most Accurate Method for Predicting the Safe Depth of Orally Placed Neonatal Endotracheal Tubes (ETT).
Status: COMPLETED
Conditions: Infant Showing No Response to Resuscitation|Ventilator Adverse Event|Apparent Life Threatening Event in Newborn and Infant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nivolumab Combined With Daratumumab With or Without Low-dose Cyclophosphamide
Status: COMPLETED
Conditions: Myeloma
Interventions: DRUG: nivolumab-daratumumab|DRUG: nivolumab-daratumumab with low-dose cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof-of-concept Study of 'JIA Toolbox' for Children and Young People (CYP) With Juvenile Idiopathic Arthritis (JIA)
Status: COMPLETED
Conditions: Rheumatologic Disease
Interventions: DEVICE: Heating prototype (Prototype 1)|DEVICE: Physio tool (Prototype 2)|DEVICE: Communication tool (Prototype 3)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prospective Comparative Study Between Ultrasound-guided Continuous Erector Spinae Plane Block and the Use of Intravenous Patient Controlled Analgesia for Management of Pain in Patients With Multiple Fracture Ribs
Status: NOT_YET_RECRUITING
Conditions: Multiple Fracture Ribs
Interventions: DRUG: amixture 0.125% bupivicaine with fentanyl|DRUG: 100 ml volume containing 80 mg of nalbuphine ,180 mg ketorolac, 24mg dexamethasone, 16 mg danset
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Generating Evidence for a Support Package to Stabilize Youth Trajectories Out of Homelessness
Status: COMPLETED
Conditions: Youth|Homelessness
Interventions: BEHAVIORAL: HOP-C|BEHAVIORAL: Transitional Case Management Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EVASION: Effect of VisuAl Stimulation on attentION
Status: NOT_YET_RECRUITING
Conditions: Dysexecutive Mild Cognitive Impairment
Interventions: PROCEDURE: Visual cognitive stimulation exercises|PROCEDURE: Broadcast of a television program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Pre-operative Exercise in Abdominal Aortic Aneurysms (AAA) Patients.
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: OTHER: Supervised exercise|OTHER: Role of exercise|OTHER: Supervised exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Azacitidine Combined With Venetoclax and ATRA in Newly Diagnosed AML
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine Combined With Venetoclax and ATRA group
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Topiramate in Treatment of Bipolar Mania and Alcohol Use in Adolescents and Young Adults
Status: COMPLETED
Conditions: Bipolar Disorder|Alcohol Abuse
Interventions: DRUG: quetiapine and placebo|DRUG: Quetiapine and Topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of NP-101 in Patients With Unresectable Hepatocellular Carcinoma (HCC) Undergoing Y-90 Treatment
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: NP-101 (3 g)|DRUG: NP-101 (4.8 g)|DRUG: NP-101 (6 g)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess YH003 in Combination With Toripalimab(Anti-PD-1 mAb) Injection in Patients With Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma|Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: YH003|DRUG: Toripalimab|DRUG: Nab-paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Vitamin D Supplementation on Serum BDNF Level and Cognitive Function in Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DRUG: Cholecalciferol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nicotine Withdrawal and Reward Processing: Connecting Neurobiology to Real-world Behavior
Status: TERMINATED
Conditions: Cigarette Smoking|Nicotine Withdrawal
Interventions: OTHER: Smoking Abstinence|OTHER: Ad Lib Smoking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant Sintilimab Plus Chemoradiotherapy for Locally Advanced Adenocarcinoma of Esophagogastric Junction
Status: RECRUITING
Conditions: PD-1|Neoadjuvant Chemoradiotherapy|Gastroesophageal Junction Cancer
Interventions: DRUG: PD-1inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Metronomic Poly-chemotherapy for Metastatic CRC
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Capecitabine|DRUG: Cyclophosphamide|DRUG: Methotrexate|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of the Use of the PICSI Dish (Hyaluronan Microdot) in the Selection of Sperm for Intracytoplasmic Sperm Injection (ICSI)
Status: COMPLETED
Conditions: Male Factor Infertility
Interventions: DEVICE: PICSI dish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Same-Day Treatment With Genvoya vs. EFV/TDF/3TC
Status: WITHDRAWN
Conditions: HIV/AIDS
Interventions: DRUG: Elvitegravir, Cobicistat, TAF, FTC|DRUG: Efavirenz, TDF, and 3TC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone Plus Bupivacaine Versus Bupivacaine in Bilateral Trans-incisional Paravertebral Block in Lumbar Spine Surgeries .
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Dexamethasone+ Bupivacaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Iodinated Contrast Media Induced Hyperthyroidism
Status: COMPLETED
Conditions: Hyperthyroidism/Thyrotoxicosis|Hyperthyroidism; Goiter|Iodine Induced Thyrotoxicosis|Contrast Media Adverse Reaction|Thyrotoxicosis of Other Specified Origin
Interventions: PROCEDURE: Administration of iodinated contrast media|DRUG: Prophylactic administration of antithyroid drugs before iodinated contrast media exposure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of a Treadmill Gait Training Protocol in a Gamified Virtual Reality Environment With tDCS in Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: OTHER: Gamified virtual reality treadmill gait training with tDCS|OTHER: Gamified virtual reality treadmill gait training|OTHER: Treadmill gait training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Dihydroartemisinin-piperaquine (DHP) for the Treatment of Uncomplicated Malaria
Status: COMPLETED
Conditions: Plasmodium Falciparum Infection|Plasmodium Vivax Infection
Interventions: DRUG: Dihydroartemisinin-Piperaquine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enhancing the Efficiency of EMLA Cream in Palatal Anesthesia for Children
Status: COMPLETED
Conditions: Extrusion of Tooth
Interventions: OTHER: Conventional local palatine injection|DRUG: EMLA cream only|DRUG: chemical permeability enhancer DMSO with EMLA cream|DRUG: Oral patches with EMLA Cream|DRUG: Micro-needle patches dissolved with EMLA Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between P2Y12 Antagonist Monotherapy and Dual Antiplatelet Therapy After DES
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: P2Y12 antagonist monotherapy|DRUG: aspirin plus P2Y12 antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Colchicine on the Progression of Aortic Valve Stenosis - A Pilot Study
Status: RECRUITING
Conditions: Aortic Stenosis|Inflammation
Interventions: DRUG: Colchicine 0.6 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A 4-week Study to Test Different Doses of BI 1265162 in Adolescents and Adults With Cystic Fibrosis Using the Respimat® Inhaler - BALANCE - CF™1
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DRUG: BI 1265162|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Dynavax's 1018 ISS, Following Rituxan in Patients With B-Cell Follicular Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Rituxan|DRUG: 1018 ISS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alzheimer's Disease - Input of Vitamin D With mEmantine Assay
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Memantine|DRUG: Vitamin D|DRUG: Vitamin D placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined HAIC, TKI/Anti-VEGF and ICIs as Conversion Therapy for Unresectable Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma Non-resectable
Interventions: PROCEDURE: HAIC|DRUG: Bevacizumab plus Atezolizumab|DRUG: Bevacizumab Biosimilar IBI305 plus sintilimab|DRUG: Lenvatinib|DRUG: Sorafenib|DRUG: Donafenib|DRUG: Regorafenib|DRUG: apatinib plus camrelizumab|DRUG: Anti-PD-1 monoclonal antibody
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Regulation of Coagulation in Orthopedic Surgery to Prevent Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE). A Study of BAY 59-7939 in the Prevention of VTE in Subjects Undergoing Elective Total Knee Replacement.
Status: COMPLETED
Conditions: Prevention|Venous Thromboembolism
Interventions: DRUG: Rivaroxaban (BAY59-7939)|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PALbociclib CoLlaborative Adjuvant Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Palbociclib|DRUG: Standard Adjuvant Endocrine Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Clinical Efficacy and Tolerability of hMG-IBSA s.c.in Women Undergoing COH in an ART Programme (IVF).
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: hMG-IBSA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Fulvestrant With and Without Entinostat in Postmenopausal Women With ER+ Advanced Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: Fulvestrant|DRUG: Entinostat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Virtual Reality Exercises on Patients With Post-SARS-CoV-2 Syndrome
Status: UNKNOWN
Conditions: Covid19
Interventions: OTHER: Virtual Realty Exercises|OTHER: Aerobic exercises|OTHER: conventional exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EXploring novEl Molecular Determinants of DRAvet Syndrome Phenotype Heterogeneity
Status: ENROLLING_BY_INVITATION
Conditions: Dravet Syndrome
Interventions: PROCEDURE: skin punch biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Dietary Nitric Oxide and Anthocyanins on Anaerobic Exercise Performance
Status: COMPLETED
Conditions: Exercise
Interventions: OTHER: beetroot and anthocyanin|OTHER: beetroot and placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: SCT-I10A Plus SCT510 Versus Sorafenib as First-Line Therapy for Advanced Hepatocellular Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: SCT-I10A|DRUG: SCT510|DRUG: Sorafenib 200mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide as Maintenance Treatment for HIV/HBV-coinfection
Status: UNKNOWN
Conditions: Chronic Hepatitis B in HIV Patient|Kidney Injury|Bone Diseases
Interventions: DRUG: Elvitegravir/Cobicistat/Emtricitabine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transfusion of Red Blood Cells, Tranexamic Acid and Fibrinogen Concentrate for Severe Trauma Hemorrhage at Pre-hospital Phase of Care.
Status: COMPLETED
Conditions: Polytrauma|Traumatic Hemorrhage
Interventions: DRUG: Fibrinogen Concentrate (Human) 1 MG [RiaSTAP]|BIOLOGICAL: Red blood cells concentrate|DRUG: Tranexamic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of IVAX Warfarin Tablets and Coumadin Brand Warfarin Tablets in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: IVAX Warfarin|DRUG: BMS Coumadin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Reactogenicity, Safety, Immunogenicity, and Pock Lesion Formation of a Cell-Cultured Smallpox Vaccine Compared to Dryvax®
Status: COMPLETED
Conditions: Smallpox
Interventions: BIOLOGICAL: Cell-Cultured Smallpox Vaccine compared to Dryvax®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Decidual Stromal Cells to Treat Graft-vs-Host Disease After Stem Cell Transplant for Myelodysplastic Syndrome/Myeloproliferative Neoplasm
Status: COMPLETED
Conditions: Myelodysplastic/Myeloproliferative Neoplasm|Steroid Refractory GVHD|Allogeneic Hematopoietic Cell Transplant
Interventions: BIOLOGICAL: Decidual stromal cells (DSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study the Efficacy and Safety of Rh-EPO in the Treatment of Anemia in Lymphoma
Status: UNKNOWN
Conditions: Lymphoma|Anemia
Interventions: DRUG: recombinant human erythropoietin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apixaban for Early Prevention of Recurrent Embolic Stroke and Hemorrhagic Transformation
Status: COMPLETED
Conditions: Transient Ischemic Attack|Stroke|Atrial Fibrillation
Interventions: DRUG: Apixaban|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cyclosporine A C-2h Monitoring Versus Tacrolimus C-0h Monitoring in de Novo Liver Transplant Recipients
Status: COMPLETED
Conditions: Liver Transplant
Interventions: DRUG: Cyclosporine A|DRUG: Tacrolimus|DRUG: Basiliximab|DRUG: Methylprednisolone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Multiple Robotic Gait-Devices for Improving Walking Ability in Subacute Stroke Patients
Status: RECRUITING
Conditions: Gait Disorders, Neurologic|Stroke|Walking
Interventions: DEVICE: Lexo|DEVICE: Lokomat|DEVICE: C-Mill|DEVICE: Body-weight support treadmill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety, Tolerability, and Efficacy of IDX-1197 in Combination With XELOX or Irinotecan in Patients With Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: IDX-1197+XELOX|DRUG: IDX-1197+Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebral Flow-metabolism Coupling During Adult Surgery
Status: RECRUITING
Conditions: Anesthesia
Interventions: DRUG: Propofol|DRUG: Sevoflurane|DRUG: Ephedrine|DRUG: Phenylephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Inotuzumab Ozogamicin [CMC-544] Administered In Combination With Rituximab In Subjects With Non-Hodgkin's Lymphoma (NHL)
Status: COMPLETED
Conditions: B-Cell Lymphoma
Interventions: DRUG: inotuzumab ozogamicin|DRUG: inotuzumab ozogamicin|DRUG: inotuzumab ozogamicin|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conectar Jugando: Board Games in Elementary Classrooms (6-12 Years Old) to Improve Executive Functions
Status: UNKNOWN
Conditions: Cognitive Change|Child Development
Interventions: BEHAVIORAL: Conectar Jugando Classroom Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Midodrine is Effective in Management of Intradialytic Hypotension Among Critically-ill Patients With Acute Kidney Injury
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: DRUG: midodrine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Screening Study to Identify Pediatric Patients With Hunter Syndrome Who Demonstrate Evidence of Central Nervous System (CNS) Involvement and Who Are Currently Receiving Treatment With Elaprase®
Status: COMPLETED
Conditions: Hunter Syndrome
Interventions: BEHAVIORAL: Neurobehavioral testing|OTHER: Visual and auditory assessments
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Oral Sedation With and Without Nitrous Oxide
Status: COMPLETED
Conditions: Behavior, Child
Interventions: DRUG: Midazolam-hydroxyzine with 100% O2|DRUG: Midazolam-hydroxyzine with 50% N2O/O2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of AZD7442 for Treatment of COVID-19 in Outpatient Adults
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: AZD7442|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First Time in Human (FTIH) Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Single and Repeat Doses of GSK3439171A in Healthy Subjects and to Assess Food Effect
Status: COMPLETED
Conditions: Muscular Dystrophies
Interventions: DRUG: GSK3439171A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Assess the Safety and Antitumor Activity of GEN1057 in Malignant Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced Malignant Solid Tumor|Metastatic Malignant Solid Tumor
Interventions: DRUG: GEN1057
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Healthy Mom Zone Gestational Weight Gain Management Intervention 2.0
Status: RECRUITING
Conditions: Gestational Weight Gain|Overweight and Obesity|Pregnancy|Energy Balance
Interventions: BEHAVIORAL: HMZ 2.0 Intervention|BEHAVIORAL: Attention Control Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mechanisms of Risky Alcohol Use in Young Adults: Linking Sleep to Reward- and Stress-Related Brain Function
Status: RECRUITING
Conditions: Alcohol Use Disorder
Interventions: BEHAVIORAL: Sleep extension and advance|BEHAVIORAL: Regular sleep duration and timing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Instrumental Chiropractic Treatment Using Activator Methods for Pain and Dysfunction in Juvenile Athletes
Status: COMPLETED
Conditions: Pain in Leg, Unspecified|Knee Sprain
Interventions: DEVICE: Activator IV (Activator Methods Int. Phoenix, Arizona)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: NK Activity Modulation Induced by Intravenous Lidocaine During Colorectal Laparoscopic Surgery
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: Intravenous Lidocaine|DRUG: Normal saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Extension Study to Evaluate the Efficacy and Safety of Elagolix in Premenopausal Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids
Status: COMPLETED
Conditions: Uterine Fibroids|Heavy Menstrual Bleeding
Interventions: DRUG: Estradiol/Norethindrone Acetate|DRUG: Elagolix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sintilimab (One Anti-PD-1 Antibody) Plus Low-dose Bevacizumab for ctDNAlevel- Relapse and Clinical-relapse Astrocytoma
Status: NOT_YET_RECRUITING
Conditions: Astrocytoma of Brain
Interventions: DRUG: Tislelizumab plus Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of Voxilaprevir in Adults With Chronic Hepatitis C Virus Infection
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: Voxilaprevir|DRUG: Placebo to match voxilaprevir|DRUG: SOF/VEL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a Retroviral Replicating Vector Combined With a Prodrug to Treat Patients Undergoing Surgery for a Recurrent Malignant Brain Tumor
Status: COMPLETED
Conditions: Glioblastoma Multiforme|Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|Anaplastic Oligoastrocytoma
Interventions: BIOLOGICAL: Toca 511 vector|DRUG: Toca FC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of EXG102-031 in Patients With wAMD (Everest)
Status: RECRUITING
Conditions: Neovascular (Wet) Age-related Macular Degeneration (nAMD)
Interventions: BIOLOGICAL: EXG102-031
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ED90 of Epidural Bupivacaine With Lidocaine for the Initiation of Labor Analgesia
Status: RECRUITING
Conditions: Labor Pain|Analgesia
Interventions: DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Audistim® Day/Night on Hearing Comfort and Patient Quality of Life of Patients With Chronic Tinnitus.
Status: COMPLETED
Conditions: Tinnitus
Interventions: DIETARY_SUPPLEMENT: Plant extracts, vitamins and mineral|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: GM604 Phase 2A Randomized Double-blind Placebo Controlled Pilot Trial in Amyotrophic Lateral Disease (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: GM604|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Meditation on Improving Quality of Life Among Glaucoma Patients: An Electronic Pilot Feasibility Study
Status: NOT_YET_RECRUITING
Conditions: Glaucoma|Depression|Anxiety|Sleep Disorder|Quality of Life
Interventions: BEHAVIORAL: Meditation to Remove Stress and Create A Proper System in Mind
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Registry on Augmented Antithrombotic Treatment Regimens for Patients With Arterial Thrombotic APS
Status: RECRUITING
Conditions: Antiphospholipid Syndrome|Arterial Thrombosis
Interventions: DRUG: Dual antiplatelet therapy|DRUG: Combined antithrombotic therapy|DRUG: Vitamin K antagonist standard intensity|DRUG: Vitamin K antagonist high intensity
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vitamin D and Type 2 Diabetes Study
Status: COMPLETED
Conditions: Prediabetes|Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Vitamin D (Cholecalciferol)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Caregiver Outlook: An Intervention to Improve Caregiving in Serious Illness
Status: COMPLETED
Conditions: Heart Failure|Pulmonary Disease|Cancer
Interventions: OTHER: Preparation and life completion|OTHER: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prolonged Hypercoagulability Following Major Liver Resection for Malignancy
Status: NOT_YET_RECRUITING
Conditions: Hepatic Disease|Surgery-Complications|Hypercoagulability|Thrombosis
Interventions: DRUG: Redesca (enoxaparin sodium for injection)|DRUG: Fragmin (dalteparin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sentinel - Triaging Acute Breathlessness Using Multi-Modal Biomarkers
Status: WITHDRAWN
Conditions: Breathlessness|COPD|Asthma|Asthma Chronic|Wheezing|Dyspnea|Shortness of Breath
Interventions: OTHER: Biomarker tests for participant profiling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vacuum-Assisted Evacuation (VAE) Of Symptomatic and/or Voluminous Breast Haematomas Following Surgeries And Percutaneous Procedures: a Retrospective Analysis
Status: COMPLETED
Conditions: Breast Haematoma|Breast Cancer|Breast Diseases
Interventions: DEVICE: Hematoma Vaacum Assisted Biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The OMEGA Study: Use of Eye Drops to Treat Geographic Atrophy Associated With Age-Related Macular Degeneration (Dry AMD)
Status: UNKNOWN
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: OT-551|DRUG: OT-551|DRUG: vehicle placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Traumatic Bone Defects in Tibial Plateau Fractures With Antibiotic-Impregnated Biodegradable Calcium Sulfate Beads: A Prospective Clinical Trial
Status: COMPLETED
Conditions: Tibial Fractures|Intra-Articular Fractures|Fracture Fixation, Internal
Interventions: DEVICE: Calcium Sulfate + Antibiotics + Internal Fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Probiotic Supplement In Improving Attention Deficit Hyperactivity Disorder Symptoms
Status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DIETARY_SUPPLEMENT: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of BDB018: Monotherapy and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Tumor, Solid
Interventions: DRUG: BDB018|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Regorafenib in Combination With Nivolumab and Short-course Radiotherapy in Stage II-III Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer Stage II|Rectal Cancer Stage III
Interventions: DRUG: Nivolumab 10 MG/ML Intravenous Solution|DRUG: Regorafenib 30 MG Oral Tablet|RADIATION: Radiotherapy|PROCEDURE: Surgery|PROCEDURE: Non-operative Management
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Milestones of Adjustment Post-Psychosis
Status: TERMINATED
Conditions: Schizophrenia|Quality of Life|Adjustment, Psychological|Medication Adherence|Signs and Symptoms
Interventions: BEHAVIORAL: Training in all modules including MAPP Recovery Model|BEHAVIORAL: Training in all modules except MAPP Recovery Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Postdural Punction Headache After Ceserian Section
Status: COMPLETED
Conditions: Postdural Puncture Headache|Regional Anesthesia Morbidity|Pregnancy Related
Interventions: PROCEDURE: Patients who underwent cesarean section under spinal anesthesia with 25 gauge spinal needle|PROCEDURE: Patients who underwent cesarean section under spinal anesthesia with 26 gauge spinal needle|PROCEDURE: Patients who underwent cesarean section operation under spinal anesthesia with 27 gauge spinal needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Influence of Nutrition in Depression Treatment (INDEPT)
Status: RECRUITING
Conditions: Major Depressive Disorder - MDD
Interventions: BEHAVIORAL: Promotion of adherence to the MedDiet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers in Post-Menopausal Women Receiving Flaxseed
Status: COMPLETED
Conditions: No Evidence of Disease
Interventions: OTHER: Clinical Observation|DIETARY_SUPPLEMENT: Flaxseed|OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Singulair Use in Non-Allergic Rhinitis Eosinophil Syndrome (NARES)
Status: UNKNOWN
Conditions: Rhinitis
Interventions: DRUG: montelukast|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Two Marketed Ocular Anti-Allergy Medications in Subjects With Allergic Conjunctivitis
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: Elestat|DRUG: Pataday
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Peer Support for Increasing Physical Activity in People With Serious Mental Illnesses
Status: COMPLETED
Conditions: Schizophrenia|Depression|Bipolar Disorder|Anxiety Disorders|Cognitive Disorders|Personality Disorders
Interventions: BEHAVIORAL: Physical activity intervention with peer support (PA+PS)|BEHAVIORAL: Physical activity intervention without peer support (PA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT