pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Impact of Hepatitis B Immunoglobulins in Patients With Chronic Hepatitis B on Hepatocellular Carcinoma - a Proof of Concept Study
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma|HBV
Interventions: DRUG: Hepatect CP 50 I.E./ml infusion solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BBI608 in Adult Patients With Advanced, Refractory Hematologic Malignancies
Status: COMPLETED
Conditions: Hematologic Malignancy
Interventions: DRUG: BBI608|DRUG: Dexamethasone|DRUG: Bortezomib|DRUG: Imatinib|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OPN-375 Efficacy and Safety in Adolescents With Bilateral Nasal Polyps
Status: RECRUITING
Conditions: Bilateral Nasal Polyposis
Interventions: DRUG: OPN-375
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First-line Treatment of Participants With Stage IV Squamous Non-Small Cell Lung Cancer With Necitumumab and Gemcitabine-Cisplatin
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: Necitumumab|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Healicoil Suture Anchor for Rotator Cuff Repair
Status: COMPLETED
Conditions: Rotator Cuff Tear Repair Anchors
Interventions: DEVICE: Smith & Nephew Healicoil Anchor|DEVICE: Smith & Nephew Twinfix Anchor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Community Setting Study of Malaria After Systematic Treatment of Symptomatic Carriers of P. Falciparum With COA566 (Coartem®)
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: COA566
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An RCT of a Primary Care-Based PTSD Intervention: Clinician-Supported PTSD Coach
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Clinician-Supported PTSD Coach|BEHAVIORAL: Primary Care Mental Health Integrated Care as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment of Biliary Tract Cancer Patients With Peritoneal Metastases
Status: RECRUITING
Conditions: Distal Bile Duct Adenocarcinoma|Gallbladder Carcinoma|Intrahepatic Cholangiocarcinoma|Metastatic Malignant Neoplasm in the Peritoneum|Stage IV Distal Bile Duct Cancer AJCC v8|Stage IV Intrahepatic Bile Duct Cancer AJCC v8|Stage IV Intrahepatic Cholangiocarcinoma AJCC v8|Stage IVB Gallbladder Cancer AJCC v8
Interventions: DRUG: Cisplatin|DRUG: Gemcitabine|DRUG: Nab-paclitaxel|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing Response to Treatment in Non-Hodgkin's Lymphoma Patients Using 64Cu-DOTA-Rituximab PET/CT
Status: WITHDRAWN
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Cu-64 Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Influence of Needle Diameter on Post Dural Puncture Headache
Status: TERMINATED
Conditions: Post-Dural Puncture Headache
Interventions: DEVICE: G25 pencil point needle|DEVICE: G27 pencil point needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Convalescent Plasma vs Human Immunoglobulin to Treat COVID-19 Pneumonia
Status: COMPLETED
Conditions: COVID-19 Pneumonia
Interventions: DRUG: Plasma from COVID-19 convalescent patient|DRUG: Human immunoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aquatic Exercise and Efficacy Enhancement to Decrease Fall Risk in Older Adults With Hip Osteoarthritis
Status: COMPLETED
Conditions: Arthritis
Interventions: BEHAVIORAL: exercise|BEHAVIORAL: 2|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rapid Research in Diagnostics Development for TB Network
Status: RECRUITING
Conditions: Tuberculosis
Interventions: DIAGNOSTIC_TEST: Novel mycobacterial culture techniques|DIAGNOSTIC_TEST: Novel sputum smear microscopy techniques|DIAGNOSTIC_TEST: Sputum-based molecular assays|DIAGNOSTIC_TEST: Tongue swab-based molecular assays|DIAGNOSTIC_TEST: Urine LAM assays|DIAGNOSTIC_TEST: Blood-based host immune response assays|DIAGNOSTIC_TEST: Breath-based assays|DIAGNOSTIC_TEST: Artificial intelligence-based digital health tools|DIAGNOSTIC_TEST: Phage-based assays|DIAGNOSTIC_TEST: Cartridge-based molecular assays for detecting drug resistance|DIAGNOSTIC_TEST: Sequencing-based assays for detecting drug resistance
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Testicular Elastography for Microscopic Testicular Sperm Extraction
Status: COMPLETED
Conditions: Azoospermia|Elasticity Imaging Techniques|Fertility Preservation
Interventions: DIAGNOSTIC_TEST: testicular elastography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ASLAN001 in Patients With Advanced or Metastatic Cholangiocarcinoma Who Progressed on at Least 1 Line of Systemic Therapy
Status: COMPLETED
Conditions: Cholangiocarcinoma
Interventions: DRUG: Varlitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Suitability of Two Skin Care Regimens in Moderate to Severe Facial Rosacea
Status: COMPLETED
Conditions: Rosacea
Interventions: OTHER: Burt's Bees Skin Care Regimen|OTHER: Control Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of FDA022-BB05 in Subjects With Advanced Solid Malignant Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: FDA022 Monoclonal antibody-drug conjugate for injection Phase Ia|DRUG: FDA022 Monoclonal antibody-drug conjugate for injection Phase Ib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanical Ventilation With Neurally-Adjusted Ventilatory Assist in Patients With ARDS
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome
Interventions: OTHER: Pressure Support ventilation|DEVICE: NAVA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Intermediate Cervical Plexus Block and Additional Perivascular Local Anesthetic Infiltration
Status: COMPLETED
Conditions: Carotid Stenosis
Interventions: DRUG: intermediate cervical plexus block ropivacaine|DRUG: pericarotidal infiltration (active comparator) ropivacaine|DRUG: jugular infiltration prilocaine|DRUG: pericarotidal infiltration (placebo comparator) saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pathomechanism of MicroRNA-29 in Shoulder Stiffness
Status: UNKNOWN
Conditions: Stiffness of Shoulder, Not Elsewhere Classified
Interventions: BIOLOGICAL: miR 29a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Brain and Central Nervous System Tumors|Neurotoxicity
Interventions: DRUG: temozolomide|RADIATION: 3-dimensional conformal radiation therapy|RADIATION: intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Dex as Analgesic Adjuvant in OSA Patients
Status: WITHDRAWN
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Impact of Direct Conversation With Patients in the Compliance With the "Split-dose" Regimen Preparation for Colonoscopy Scheduled in the First Part of the Morning
Status: COMPLETED
Conditions: Colonoscopy Preparation Acceptance
Interventions: OTHER: written + oral explanation|OTHER: written explanation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Proteoglycan 4 Mechanism the Effectiveness of Pulmaonry Recovery in COPD Patients
Status: UNKNOWN
Conditions: COPD
Interventions: DEVICE: Pulmonary recovery on the AECOPD|OTHER: Routine care on the AECOPD|OTHER: Routine care on the stable COPD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Learn Whether There Are Differences in the Kidney's Ability to Work Properly in Korean Patients With Non-valvular Atrial Fibrillation (Irregular and Often Rapid Heartbeat Not Caused by a Heart Valve Problem) Treated With Rivaroxaban as Compared to Those Treated With Warfarin
Status: COMPLETED
Conditions: Non-valvular Atrial Fibrillation (NVAF)
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)|DRUG: Warfarin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of an Opioid on the Lower Esophageal Sphincter During Anesthesia Induction
Status: COMPLETED
Conditions: Lower Esophageal Sphincter
Interventions: DRUG: alfentanil|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Chronic Obstructive Pulmonary Disease Endpoints Study
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Fluticasone Propionate/Salmeterol 500/50mcg combination|DRUG: Fluticasone Propionate 500mcg|DRUG: Salmeterol 50mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Pharmacokinetic Profile, the Safety, and the Tolerability of ME1100 Inhalation Solution in Patients With Mechanically Ventilated Bacterial Pneumonia
Status: COMPLETED
Conditions: Pneumonia, Bacterial
Interventions: DRUG: ME1100 inhalation solution|DRUG: ME1100 inhalation solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Specialty Compared to Oncology Delivered Palliative Care for Patients With Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Relapsed Adult AML|Primary Refractory Acute Myeloid Leukemia|High Risk Acute Myeloid Leukemia
Interventions: BEHAVIORAL: Specialty Palliative Care|BEHAVIORAL: Primary Palliative Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hyper Baric Oxygen Therapy (HBOT) for Spontaneous Osteonecrosis of the Knee
Status: UNKNOWN
Conditions: Spontaneous Osteonecrosis of the Knee
Interventions: BIOLOGICAL: Weight reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacology-driven Dosing of Fluoropyrimidines in Cancer Patients
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: OTHER: 5FU and capecitabine (Xeloda®) dosing based on DPYD genotype|OTHER: Therapeutic drug monitoring of 5FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coffee After Pancreatic Surgery
Status: UNKNOWN
Conditions: Postoperative Ileus|Postoperative Complications|Bowel Dysfunction|Pancreatic Diseases
Interventions: DIETARY_SUPPLEMENT: Standard coffee|DIETARY_SUPPLEMENT: Caffeine-free coffee|DIETARY_SUPPLEMENT: Drinking water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Preventing Suicidal Behavior With Diverse High-Risk Youth in Acute Care Settings
Status: NOT_YET_RECRUITING
Conditions: Suicide, Attempted|Suicide Ideation|Suicide|Suicide Prevention
Interventions: BEHAVIORAL: Stanley Brown Safety Planning Intervention and Follow-up Contacts (SPI+)|BEHAVIORAL: Interpersonal Psychotherapy for Adolescents Ultra Short Crisis Intervention (IPT-A SCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole on Patients With Chronic Periodontitis
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: DRUG: moxifloxacin|DRUG: Ciprofloxacin plus metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effects of MK0822 in Reducing the Risk of Bone Metastasis in Women With Breast Cancer (0822-029)
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: Comparator: odanacatib|DRUG: Comparator: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Metformin Safety and Efficacy in Osteoarthritis.
Status: RECRUITING
Conditions: Osteo Arthritis Knee
Interventions: DRUG: Celecoxib 200mg|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Efficacy of Conservative Treatment With Minimally Invasive Surgery in the Treatment of Rib Fractures
Status: UNKNOWN
Conditions: Chest Trauma|Rib Fractures|Surgery--Complications
Interventions: PROCEDURE: surgical treatment|PROCEDURE: Conservative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cryotherapy for Prevention of Oral Mucositis in Children Undergoing Hematopoietic Stem Cell Transplantation
Status: COMPLETED
Conditions: Oral Mucositis|Pain|Infection|Nutrition Aspect of Cancer
Interventions: OTHER: Cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: High Versus Low Bicarbonate Bath in Critically-ill Patients Receiving Continuous Renal Replacement Therapy
Status: WITHDRAWN
Conditions: Metabolic Acidosis|Acute Kidney Injury|Acute Kidney Failure
Interventions: DRUG: Low bicarbonate solution (22 mmol/L)|DRUG: High Bicarbonate solution (32 mmol/L)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sodium Stibogluconate and Interferon in Treating Patients With Advanced Solid Tumors, Lymphoma, or Myeloma
Status: TERMINATED
Conditions: Cancer
Interventions: BIOLOGICAL: recombinant interferon alfa-2b|DRUG: sodium stibogluconate|DRUG: SSG & interferon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Corneas Undergoing Balanced Salt Solution(BSS ®) Versus Glucose-bicarbonate-Ringer Lactate in Cataract Surgery
Status: COMPLETED
Conditions: Cataract
Interventions: PROCEDURE: Phacoemulsification cataract surgery|DRUG: Glucose-bicarbonate-Ringer Lactate (GBRL)|DRUG: Balanced Salt Solution (BSS®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketamine Interleaved With Electroconvulsive Therapy for Depression
Status: TERMINATED
Conditions: Depression
Interventions: DRUG: Ketamine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Synthetic Male Condom Slippage-Breakage Study
Status: COMPLETED
Conditions: Contraceptive|Sexually Transmitted Diseases
Interventions: DEVICE: Test Product|DEVICE: Control Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Adhesion Quality of a New Formulation of the Mylan Estradiol Transdermal System 0.025 mg/Day and Climara® Transdermal System 0.025 mg/Day
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Mylan Estradiol Transdermal System 0.025 mg/day|DRUG: Climara® Transdermal System 0.025 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Improving Sleep in Veterans With the Polytrauma Clinical Triad
Status: NOT_YET_RECRUITING
Conditions: Traumatic Brain Injury|Post-traumatic Stress Disorder|Chronic Pain
Interventions: DEVICE: Morning Bright Light Therapy|DEVICE: Negative Ion Generator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pre-surgical Information Session for People Who Must Undergo Shoulder Rotator Cuff Surgery
Status: RECRUITING
Conditions: Rotator Cuff Injuries|Surgery|Empowerment, Patient
Interventions: BEHAVIORAL: Evaluation of the impact of a pre-surgical information session for people who must undergo shoulder rotator cuff surgery on empowerment for their functional rehabilitation process.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultrasound Guidance Versus Anatomical Landmarks for Subclavian Vein Catheterization
Status: COMPLETED
Conditions: Central Venous Catheterization
Interventions: DEVICE: cathetherization approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of NYX-2925 in Subjects With Neuropathic Pain Associated With Diabetic Peripheral Neuropathy (DPN)
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathic Pain
Interventions: DRUG: NYX-2925 50 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation on Dysphagia in the Stroke Patient
Status: RECRUITING
Conditions: Stroke|Dysphagia|Repetitive Transcranial Magnetic Stimulation
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation|DEVICE: Neuromuscular electrical stimulation combined with conventional swallowing training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compression Bandaging and Manual Lymph Drainage in Women With Lymphedema
Status: UNKNOWN
Conditions: Arm Lymphedema After Breast Cancer
Interventions: OTHER: Multimodal treatment: compression bandaging and manual lymph drainage.|OTHER: Manual lymph drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CLN-049 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)
Status: RECRUITING
Conditions: Relapsed/Refractory Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome (MDS)
Interventions: DRUG: CLN-049
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study Looking at the Effect of Semaglutide on the Immune System and Other Biological Processes in People With Alzheimer's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimers Disease
Interventions: DRUG: Semaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EMPOWER Early Feasibility Study: Non-invasive BCI to Control a Wheelchair for People With Paralysis
Status: NOT_YET_RECRUITING
Conditions: Neurologic Disorder|Paralysis|Paralysis; Stroke|Amyotrophic Lateral Sclerosis|Spinal Cord Injuries|Cervical Spinal Cord Injury|Tetraplegic; Paralysis|Quadriplegia/Tetraplegia
Interventions: DEVICE: Intervention/Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: The Efficiency and Gingival Health Status of Hall Versus SDF Techniques in the Management of Carious Primary Molars
Status: UNKNOWN
Conditions: Caries
Interventions: DRUG: Silver diamine fluoride|DEVICE: hall technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Hematopoietic Stem Cell Transplantation After Reduced-intensity Conditioning for Relapsed Follicular Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Follicular|Stem Cell Transplantation
Interventions: DRUG: Reduced_intensity conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Treatment for the Displaced JakobⅡ Classification Humerus Lateral Condylar Fractures in Children
Status: COMPLETED
Conditions: Lateral Condyle Fractures,Humerus,JakobⅡ Classification,Reduction
Interventions: PROCEDURE: Closed reduction|PROCEDURE: Open reduction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Semaglutide Anti-Atherosclerotic Mechanisms of Action Study in Type 2 Diabetes Patients
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Atherosclerosis
Interventions: DRUG: Semaglutide Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Smoking Cessation Using Motivational Therapy and Varenicline
Status: COMPLETED
Conditions: Smoking|HIV Infections
Interventions: DRUG: Varenicline tartrate|DRUG: Nicotine Replacement Therapy|OTHER: Biological Control|BEHAVIORAL: Motivational Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Interrupting Sedentary Time in Management of Type-2 Diabetes
Status: UNKNOWN
Conditions: Diabetes
Interventions: BEHAVIORAL: Sedentary time breaks either every 60 minutes|BEHAVIORAL: Sedentary time breaks either every 30 minutes|BEHAVIORAL: Sedentary time breaks every 15 minutes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation D_SAF Pilot Study
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: 25,000 IU|DIETARY_SUPPLEMENT: 50,000 IU|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Early Occupational Therapy for Delirium Prevention in Older Patients Admitted to Critical Care Unit
Status: COMPLETED
Conditions: Delirium|Alteration of Cognitive Function|Incompetence, Functional
Interventions: BEHAVIORAL: Early and Intensive Occupational Therapy|BEHAVIORAL: Standard non-pharmacological delirium prevention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating Preference, Satisfaction and Ease of Use of Inhalers in Chronic Obstructive Pulmonary Disease (COPD) Diagnosed Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DEVICE: Genuair® (Almirall S.A.)|DEVICE: HandiHaler® (Boehringer Ingelheim's)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Window of Opportunity Trial of Neoadjuvant Olaparib and Durvalumab for Triple Negative or Low ER+ Breast Cancer
Status: UNKNOWN
Conditions: Breast Neoplasms
Interventions: DRUG: Olaparib|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of High-dose Intravenous Vitamin c With Very Low Carbohydrate Diet for Terminal Colon Cancer Patients
Status: UNKNOWN
Conditions: Colon Cancer Stage Iv
Interventions: DRUG: Ascorbic Acid|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decitabine in Treating Children With Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia
Status: TERMINATED
Conditions: Childhood Acute Myeloblastic Leukemia With Maturation (M2)|Childhood Acute Promyelocytic Leukemia (M3)|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia
Interventions: DRUG: decitabine|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Bisacodyl Suppository Agent for Dose Reduction of Low Dose PEG
Status: COMPLETED
Conditions: Bowel Preparation
Interventions: DRUG: 2L PEG-Asc|DRUG: Bisacodyl 10Mg Suppository|DRUG: 1L PEG-Asc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of Testosterone Replacement Therapy on Blood Pressure in Adult Male Participants With Hypogonadism
Status: COMPLETED
Conditions: Hypogonadism|Hypogonadism, Male|Hypogonadotropic Hypogonadism
Interventions: DRUG: Aveed Injectable Product|DRUG: Fortesta|DRUG: Testim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carfilzomib, Pomalidomide, and Dexamethasone in Treating Patients With High-Risk Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Plasma Cell Myeloma
Interventions: DRUG: Carfilzomib|DRUG: Dexamethasone|DRUG: Pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study to Evaluate MT-6548 in Non-dialysis Subjects With Anemia Associated With Chronic Kidney Disease in Japan
Status: COMPLETED
Conditions: Anemia; Non-dialysis Dependent Chronic Kidney Disease
Interventions: DRUG: MT-6548|DRUG: Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Fasting to Improve Insulin Secretion
Status: RECRUITING
Conditions: PreDiabetes|Diabetes type2|Intermittent Fasting|Insulin Secretion
Interventions: BEHAVIORAL: Intermittent fasting|BEHAVIORAL: Control diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of a Hypertensive Population Under Treatment With Micardis® and Micardis Plus® to Control the Early Morning BP Rise (SURGE II)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan|DRUG: Telmisartan hydrochlorothiazide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial to Assess the Bioavailability of Quetiapine Versus Seroquel® in Subjects With Schizophrenia or Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder|Schizophrenia
Interventions: DRUG: Seroquel IR 300mg|DRUG: Seroquel IR 25mg|DRUG: Quetiapine Formulation A 300mg|DRUG: Quetiapine Formulation B 300mg|DRUG: Quetiapine Formulation 25mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Denosumab and Male Infertility: a RCT
Status: COMPLETED
Conditions: Infertility, Male
Interventions: DRUG: Denosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men and Women to Test Which Effects Donepezil and BI 425809 Have on Each Other
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 425809|DRUG: Donepezil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mismatched Family Member Donor Transplantation for Children and Young Adults With High Risk Hematological Malignancies
Status: COMPLETED
Conditions: Leukemia, Acute Lymphocytic (ALL)|Leukemia, Myeloid, Acute(AML)|Leukemia, Myeloid, Chronic(CML)|Juvenile Myelomonocytic Leukemia (JMML)|Hemoglobinuria, Paroxysmal Nocturnal (PNH)|Hodgkin Lymphoma|Lymphoma, Non-Hodgkin (NHL)|Myelodysplastic Syndrome (MDS)
Interventions: DEVICE: CliniMACS|PROCEDURE: Stem cell transplantation|DRUG: Fludarabine|DRUG: Thioplex®|DRUG: L-phenylalanine mustard|DRUG: Mycophenolate mofetil|DRUG: Rituxan™|DRUG: Alemtuzumab|DRUG: Cyclophosphamide|DRUG: Anti-thymocyte globulin (Rabbit)|DRUG: G-CSF|DRUG: Muromonab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epirubicin and Rituximab in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: epirubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Longitudinal Follow-up of Male Soccer Players Prone to Developing CAM Hip Deformity
Status: ACTIVE_NOT_RECRUITING
Conditions: Femoro Acetabular Impingement|CAM
Interventions: RADIATION: bi-planer radiography (EOS), Conventional radiography (Hip+pelvis)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Inhaled Xylitol Versus Saline in Stable Subjects With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Xylitol|DRUG: Hypertonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Erythropoietin for Cognitive Side-effects of ECT
Status: COMPLETED
Conditions: ECT|Cognitive Impairment|Unipolar Depression|Bipolar Depression
Interventions: DRUG: Erythropoietin|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irbesartan and Adhesion Molecules in AF
Status: UNKNOWN
Conditions: Persistent Atrial Fibrillation
Interventions: DRUG: irbesartan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Stromal Cell-Derived Factor-1 (SDF-1)/CXC Chemokine Receptor 4 (CXCR4) in Metastasis of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Laryngeal Cancer|Hypopharyngeal Cancer|Metastasis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Tumor Treating Fields (TTFields, 200 kHz) Concomitant With Weekly Paclitaxel for the Treatment of Recurrent Ovarian Cancer (ENGOT-ov50 / GOG-3029 / INNOVATE-3)
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DEVICE: NovoTTF-100L(O)|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digital Variance Angiography in Diagnostic Angiographies for Effective Radiation Dose Reduction
Status: COMPLETED
Conditions: Peripheral Arterial Disease|Peripheral Artery Disease|Femoral Artery Stenosis|Femoral Artery Occlusion|Popliteal Stenosis|Iliac Artery Stenosis|Crural Artery Thrombosis|Limb Ischemia
Interventions: RADIATION: Diagnostic Angiography (DSA or DVA based on randomization result)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase II Study of Sitravatinib in Combination With Tislelizumab in Patients With Advanced Biliary Tract Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Biliary Tract Cancer
Interventions: DRUG: Sitravatinib|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraocular Pressure Reduction With the Bimatoprost/Timolol Fixed Combination
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: Bimatoprost and Bimatoprost/Timolol fixed combination.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|PTSD|Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: CBT-OSA|BEHAVIORAL: Sleep Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ibrutinib in Treating Participants With Untreated High Risk Smoldering Mantle Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Gemcitabine and Erlotinib Plus Sorafenib (GES) in Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Erlotinib|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Treatments in Specialized Disease of Laryngeal Carcinoma (LC) and Hypopharyngeal Carcinoma (HPC)
Status: UNKNOWN
Conditions: Glottic Carcinoma|Supraglottic Carcinoma|Subglottic Carcinoma|Pyriform Sinus Carcinoma|Postcricoid Carcinoma|Posterior Pharyngeal Wall Carcinoma
Interventions: PROCEDURE: routines
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combined Occipital and Trigeminal Nerve Stimulation (eCOT-NS) for Preventive Treatment of Migraine
Status: NOT_YET_RECRUITING
Conditions: Migraine
Interventions: DEVICE: Relivion®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients Who Have Extensive-Stage Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Induction Chemotherapy in Locally Advanced HNSCC
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Nab-paclitaxel, cisplatin and Pembrolizumab combination|PROCEDURE: surgery|RADIATION: Adjuvant Chemoradiotherapy|DRUG: Radical concurrent chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing Olaparib Either Alone or in Combination With Atezolizumab in BRCA Mutant Non-HER2-positive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Locally Advanced Unresectable Breast Carcinoma|Metastatic Breast Carcinoma
Interventions: DRUG: Atezolizumab|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Olaparib|PROCEDURE: Positron Emission Tomography|OTHER: Questionnaire Administration|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on B-blockers to Prevent Decompensation of Cirrhosis With HTPortal
Status: COMPLETED
Conditions: Portal Hypertension Gastropathy|Esophageal Varices|Spontaneous Bacterial Peritonitis|Hepatic Encephalopathy|Ascites
Interventions: DRUG: propranolol|DRUG: carvedilol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Lonafarnib and Temozolomide in Treating Patients With Recurrent Primary Supratentorial Gliomas
Status: UNKNOWN
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: lonafarnib|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiochemotherapy Followed by Adjuvant Chemotherapy Based on Gemcitabine in Uterine Cervical Cancer
Status: TERMINATED
Conditions: Uterine Cervical Cancer
Interventions: DRUG: Gemcitabine|PROCEDURE: Radiotherapy|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Mavrilimumab Versus Anti Tumor Necrosis Factor in Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Golimumab 50 mg|BIOLOGICAL: Mavrilimumab 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Electroacupuncture on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy)
Status: RECRUITING
Conditions: Chemotherapy-induced Peripheral Neuropathy|Nerve Pain|Neuropathy|Neuropathy, Painful
Interventions: OTHER: Electroacupuncture|OTHER: Sham Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of a Protective Cough Syrup Against Placebo on Night Cough in Children 1-5 Years Coughing Since 1- 2 Days Due to Common Cold
Status: UNKNOWN
Conditions: Cough|Acute Upper Respiratory Tract Infection
Interventions: DEVICE: Cough Syrup for adults and children|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of SGLT-2 Inhibitors on Epicardial Adipose Tissue and Cardiac Function in T2DM Patients With CAD (EpiCAD)
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DRUG: Sodium Glucose Co-transporter 2 (SGLT2) Inhibitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of a Switch to Doravirine, Tenofovir, Lamivudine (MK-1439A) in Human Immunodeficiency Virus (HIV-1)-Infected Participants Virologically Suppressed on an Anti-retroviral Regimen in Combination With Two Nucleoside Reverse Transcriptase Inhibitors (MK-1439A-024)
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Doravirine, Tenofovir, Lamivudine|DRUG: Baseline regimen of ritonavir- or cobicistat-boosted protease inhibitor|DRUG: Baseline regimen of cobicistat-boosted elvitegravir|DRUG: Baseline regimen of a non-nucleoside reverse transcriptase inhibitor|DRUG: Baseline regimen of two nucleoside reverse transcriptase inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Letrozole in Treating Postmenopausal Women With Estrogen-Receptor Positive and/or Progesterone-Receptor Positive Stage II, Stage IIIA, or Stage IIIB Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: letrozole|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of the Sugar Sucrose on Bodyweight and Energy Intake Over 28 Days in Obese Women
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Sucrose|DIETARY_SUPPLEMENT: Aspartame
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gemcitabine/Capecitabine/ZD6474 in Advanced Solid Tumors
Status: COMPLETED
Conditions: Malignant Solid Tumour|Biliary Cancer|Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Capecitabine|DRUG: ZD6474
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation and Evaluation of Revised Protocols for Oral Hygiene for Mechanically Ventilated Patients
Status: COMPLETED
Conditions: Ventilator Associated Pneumonia|Oral Hygiene
Interventions: PROCEDURE: Standard Oral Hygiene|PROCEDURE: SAGE Q-care q2|PROCEDURE: SAGE Q-care q2 with Chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ZYNRELEF for Pain Management in Total Knee Arthroplasty
Status: RECRUITING
Conditions: Post Operative Pain|Osteoarthritis, Knee
Interventions: DRUG: Bupivacaine-Meloxicam 400 Mg-12 Mg/14 mL Injectable Solution, Extended Release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Yttrium Y 90 Anti-CD45 Monoclonal Antibody AHN-12 in Treating Patients With Advanced Leukemia
Status: TERMINATED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: anti-CD45 monoclonal antibody AHN-12|RADIATION: yttrium Y 90 anti-CD45 monoclonal antibody AHN-12
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Gemini III Rev 2 Implanted in Conjunction With an Approved IOL vs Eyes Implanted With an Approved IOL
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Omega Gemini III Rev 2 Device|DEVICE: Control Eye
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of an Interactive Consulting System to Enhance Patients' Decision-making: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Age-related Cataract
Interventions: OTHER: Interactive Consulting System|OTHER: A traditional patient decision aid brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Feasibility and Effectiveness of WhatsApp Online Group on Breastfeeding by Peer Counsellors.
Status: COMPLETED
Conditions: Breastfeeding, Exclusive|Breastfeeding
Interventions: BEHAVIORAL: WhatsApp peer support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess Cannabidiol Oral Solution With Vigabatrin as Initial Therapy in Participants With Infantile Spasms
Status: TERMINATED
Conditions: Infantile Spasm
Interventions: DRUG: Cannabidiol Oral Solution|DRUG: Placebo|DRUG: Vigabatrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Coronary In-stent Restenosis (ISR) by a Sirolimus Coated or a Paclitaxel Coated Balloon
Status: COMPLETED
Conditions: Coronary Restenosis
Interventions: COMBINATION_PRODUCT: Sirolimus coated balloon|COMBINATION_PRODUCT: Paclitaxel coated balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating Maintenance Therapy With Lamivudine (Epivir®) and Dolutegravir (Tivicay®) in Human Immunodeficiency Virus 1 (HIV-1) Infected Patients Virologically Suppressed With Triple Highly Active Antiretroviral Therapy (HAART) (ANRS 167 Lamidol)
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: dolutegravir (Tivicay®) - Phase 1|DRUG: lamivudine (Epivir®) - Phase 2|DRUG: dolutegravir (Tivicay®) - Phase 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT