pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of TRK-950 in Patients With Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor
Interventions: BIOLOGICAL: TRK-950|BIOLOGICAL: TRK-950|BIOLOGICAL: TRK-950|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluorouracil, Cisplatin, Cetuximab, and Radiation Therapy in Treating Patients With Esophageal Cancer That Can Be Removed by Surgery
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: cisplatin|DRUG: fluorouracil|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Adipose Derived Stem Cells in Refractory Rheumatoid Arthritis, Systemic Lupus Erythematosus or Sharp's Syndrome
Status: TERMINATED
Conditions: Systemic Lupus Erythematosus|Rheumatoid Arthritis|Sharp's Syndrome
Interventions: OTHER: Intravenous injection of Stromal Vascular Fraction Cells (SVF) containing ADSCs|OTHER: Lipoaspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cortisol Suppression and Startle Responses in Posttraumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: Post Traumatic Stress Disorder
Interventions: DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of IONIS FXI-LRx in up to 84 Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: IONIS FXI-LRx|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Galectin Inhibitor (GR-MD-02) and Ipilimumab in Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Metastatic Melanoma
Interventions: BIOLOGICAL: 1 mg/kg GR-MD-02|BIOLOGICAL: 2 mg/kg GR-MD-02|BIOLOGICAL: 4 mg/kg GR-MD-02|BIOLOGICAL: 8 mg/kg GR-MD-02|BIOLOGICAL: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of a Horizontal Data Integration Classifier for Noninvasive Early Diagnosis of Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DIAGNOSTIC_TEST: Blood and urine molecular analysis (Timing 0)|DIAGNOSTIC_TEST: Blood and urine molecular analysis (Timing 1)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phentermine/Topiramate as Preventive Pharmacotherapy for Obesity
Status: WITHDRAWN
Conditions: Obesity, Adolescent
Interventions: DRUG: Qsymia and lifestyle management therapy|BEHAVIORAL: Placebo and lifestyle management therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pre-emptive Analgesia on the Postoperative Pain in Children Undergoing Pediatric Stomatology Day Surgeries
Status: COMPLETED
Conditions: Ankyloglossia|Oral Mucoceles|Supernumerary Teeth
Interventions: DRUG: ibuprofen suppository
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Atrasentan in Men With Hormone Naive Prostate Cancer Exhibiting Early Signs of Biochemical Failure
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: Atrasentan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Immunogenicity Study of GSK Biologicals' Candidate Malaria Vaccine (SB257049) Evaluating Schedules With or Without Fractional Doses, Early Dose 4 and Yearly Doses, in Children 5-17 Months of Age
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: RTS,S/AS01E (Full dose)|BIOLOGICAL: RTS,S/AS01E (1/5th dose)|BIOLOGICAL: Rabies vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study To Evaluate The Effect Of A Supratherapeutic Dose Of MK-8189 On The QTc Interval In Participants With Schizophrenia (MK-8189-019)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: MK-8189|DRUG: Moxifloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Re-evaluation of Donor-specific Anti-HLA Alloantibodies Immunoassay After Organ Transplantation, From Antigen Level to Epitope Level
Status: NOT_YET_RECRUITING
Conditions: Organ Transplantation
Interventions: OTHER: DNA sequencing called "new generation" (or NGS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: DOT Diary Optimization Pilot: A Pilot Study to Optimize the DOT Diary App to Measure PrEP Adherence
Status: COMPLETED
Conditions: Adherence, Medication|Risk Behavior|Pre-Exposure Prophylaxis|HIV Prevention
Interventions: DRUG: Emtricitabine / Tenofovir Disoproxil Oral Tablet|OTHER: DOT Diary mobile app
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Flushing in Social Anxiety Disorder on Seroquel
Status: COMPLETED
Conditions: Social Anxiety Disorder
Interventions: DRUG: Seroquel|DRUG: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Pulmonary Effects of Excursion Deep Diving With Closed-circuit Gas Recycling: SPIDD Study
Status: RECRUITING
Conditions: Physiopathology
Interventions: DIAGNOSTIC_TEST: Pre and post dive examinations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Acute Effect of Crocus Sativus on Postprandial Glycemia
Status: COMPLETED
Conditions: Potential Abnormality of Glucose Tolerance|Appetitive Behavior|Blood Pressure
Interventions: OTHER: D-Glucose beverage as reference food|OTHER: 15mg of Crocus Sativus as beverage|OTHER: 30mg of Crocus Sativus as beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Twenty-Four Month Extension Study of BA058-05-003 (Abaloparatide) in Participants With Osteoporosis
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: Alendronate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gut Feeling: Understanding the Mechanisms Underlying the Antidepressant Properties of Probiotics
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DIETARY_SUPPLEMENT: Multi-strain probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interest of Intravenous Cholangiography With Indocyanine Green in the Context of Laparoscopic Cholecystectomy for Grade 1 and 2 Acute Gallstone Cholecystitis
Status: COMPLETED
Conditions: Lithiasis|Cholecystitis, Acute|Cholangiopathy
Interventions: PROCEDURE: laparoscopic cholecystectomy|DIAGNOSTIC_TEST: systematic intraoperative cholangiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Impact of Air vs SF6 20% on Visual Acuity Improvement After Epiretinal Membrane Stripping
Status: COMPLETED
Conditions: Epiretinal Membrane
Interventions: PROCEDURE: Epiretinal membrane peeling with fluid-air exchange|PROCEDURE: Epiretinal membrane peeling with fluid-SF6 exchange
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Xeloda (Capecitabine) in Combination With Oxaliplatin in Patients With Metastatic Colorectal Cancer.
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Avastin|DRUG: Oxaliplatin|DRUG: capecitabine [Xeloda]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study to Evaluate the Efficacy and Safety of Co-administrated AD-2021 and AD-2022
Status: COMPLETED
Conditions: Hypertension, Essential|Primary Hypercholesterolemia
Interventions: DRUG: AD-2021|DRUG: AD-2022|DRUG: AD-2021 Placebo|DRUG: AD-2022 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of Perturbation and Functional Stabilization Training on Patellofemoral Pain Syndrome
Status: RECRUITING
Conditions: Patellofemoral Pain Syndrome
Interventions: PROCEDURE: Functional stabilization training|PROCEDURE: perturbation exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Bladder Testing After Total Laparoscopic Hysterectomy
Status: COMPLETED
Conditions: Laparoscopic Hysterectomy|Enhanced Recovery After Surgery
Interventions: PROCEDURE: InstilIing normal saline into bladder|PROCEDURE: Removal of foley catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Interchangeability of V114 and Prevnar 13™ in Healthy Infants (V114-027/PNEU-DIRECTION)
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: Prevnar 13™|BIOLOGICAL: V114|BIOLOGICAL: RotaTeq™|BIOLOGICAL: Pentacel™|BIOLOGICAL: RECOMBIVAX HB™|BIOLOGICAL: HIBERIX™|BIOLOGICAL: M-M-R™ II|BIOLOGICAL: VARIVAX™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: An Open-Label Trial of Repetitive Transcranial Magnetic Stimulation for Opioid Use Disorder
Status: RECRUITING
Conditions: Opioid-use Disorder|Substance-Related Disorders|Chemically-Induced Disorders|Mental Disorder
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0124: Cisplatin Combined With Irinotecan or Etoposide For Extensive-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: etoposide|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of the French Version of the Sydney Swallow Questionnaire in Patients With Neuromuscular Diseases
Status: COMPLETED
Conditions: Dysphagia|Neuromuscular Diseases
Interventions: OTHER: Sydney Swallow Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Is Initial Response to Low Dose Risperidone Predictive for Outcome in Anxiety?
Status: TERMINATED
Conditions: Anxiety State
Interventions: DRUG: RisperiDONE 0.5 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nudge Strategies for DPYD Testing in Patients With Gastrointestinal Cancers Treated With Fluoropyrimidines
Status: NOT_YET_RECRUITING
Conditions: DPYD Gene Mutation|Gastrointestinal Cancer|Health Care Seeking Behavior
Interventions: OTHER: Focus Group|OTHER: Discrete Choice
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Efficacy of Paravertebral and Epidural Analgesia After Videothoracoscopic Lung Lobectomy
Status: COMPLETED
Conditions: Lung Cancer
Interventions: PROCEDURE: Continuous Thoracic Epidural Block|PROCEDURE: Continuous Thoracic Paravertebral Block|PROCEDURE: Patient-Controlled Analgesia with Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label Single-Center Study to Evaluate the Safety and Efficacy of Combining Rituximab and AB-101 in B-cell Associated Autoimmune Diseases.
Status: RECRUITING
Conditions: Rheumatoid Arthritis|Pemphigus Vulgaris|Granulomatosis With Polyangiitis|Systemic Lupus Erythematosus
Interventions: DRUG: AB-101|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dose Vitamin C Intravenous Infusion in Patients With Resectable or Metastatic Solid Tumor Malignancies
Status: COMPLETED
Conditions: Colorectal Cancer|Pancreatic Cancer|Lung Cancer
Interventions: DRUG: Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT of a Polyherbal Dietary Supplement for Prediabetes
Status: COMPLETED
Conditions: Prediabetic State
Interventions: DIETARY_SUPPLEMENT: GlucoSupreme™ Herbal|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of Purified Vero Rabies Vaccine Compared With Two Reference Rabies Vaccines in a Simulated Post-Exposure Regimen in Adults
Status: COMPLETED
Conditions: Rabies (Healthy Volunteers)
Interventions: BIOLOGICAL: VRVg-2|BIOLOGICAL: Purified Inactivated Rabies Vaccine|BIOLOGICAL: Human Diploid Cell Vaccine (HDCV)|BIOLOGICAL: Rabies immune globulin (human)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CLL Induction Treatment With Venetoclax and Ibrutinib, Followed by Ibrutinib and Obinutuzumab in Patients With MRD.
Status: ACTIVE_NOT_RECRUITING
Conditions: CLL
Interventions: DRUG: ibrutinib, venetoclax, obinutuzumab|DRUG: ibrutinib, venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Dose Ranging Study of BI 1744 CL (Olodaterol) in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: single dose of 5 mcg|DRUG: single dose of placebo|DRUG: single dose of 40 mcg|DRUG: single dose of 20 mcg|DRUG: single dose of 2 mcg|DRUG: single dose of 10 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: TMS for Suicidal Crisis in Active Duty SMs
Status: COMPLETED
Conditions: Suicide|Suicidal Ideation|Suicidal Impulses|Suicidal Intention|Suicidal and Self-Injurious Behavior|Suicidal Depression
Interventions: DEVICE: Neuronetics NeuroStar XPLOR magnetic stimulator - Active|DEVICE: Neuronetics NeuroStar XPLOR magnetic stimulator - Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Trial of AZD3480 (TC-1734) for the Treatment of Adult Attention-Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: Placebo|DRUG: AZD3480|DRUG: AZD3480
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sticky Bone and Repeated Injectable PRF (iPRF) Application in Management of Periodontal Intrabony Defects
Status: UNKNOWN
Conditions: Sticky Bone|iPRF|Periodontal Defect
Interventions: BIOLOGICAL: Sticky Bone and Repeated Injectable PRF (iPRF)|BIOLOGICAL: bone substitute
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Angiotensin Receptor Blockade on Insulin Resistance and Adipose Tissue Cytokines in Type 2 Diabetes
Status: COMPLETED
Conditions: Insulin Resistance|Type 2 Diabetes
Interventions: PROCEDURE: Hyperinsulinaemia|DRUG: Losartan|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety of Somatropin and Induction of Puberty With 17-beta-oestradiol in Girls With Turner Syndrome
Status: COMPLETED
Conditions: Genetic Disorder|Turner Syndrome
Interventions: DRUG: somatropin|DRUG: somatropin|DRUG: somatropin|DRUG: oestrogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of IBD98-M 400mg-57.5/Day in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: IBD98-M:|DRUG: IBD98-M without HA|DRUG: Delzicol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Safety and Efficacy of Talactoferrin in Addition to Standard Chemotherapy in Patients With Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Talactoferrin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Reactogenicity Trial of the Recombinant Tuberculosis Allergen in Healthy Volunteers
Status: COMPLETED
Conditions: Tuberculosis|Skin Tests
Interventions: DIAGNOSTIC_TEST: Mycobacterial recombinant allergens 0.1 μg|DIAGNOSTIC_TEST: Mycobacterial recombinant allergens 0.2 μg|DIAGNOSTIC_TEST: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Durvalumab(MEDI4736)/Tremelimumab in Combination With Gemcitabine/Cisplatin in Chemotherapy-naïve Biliary Tract Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Biliary Tract Neoplasms
Interventions: DRUG: Durvalumab|DRUG: Tremelimumab|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Successfully Achieving and Maintaining Euglycemia During Pregnancy for Type 2 Diabetes Through Technology and Coaching
Status: RECRUITING
Conditions: Pre-Gestational Diabetes|Type2diabetes|Pregnancy in Diabetic|Pregnancy, High Risk
Interventions: DEVICE: DEXCOM G7 PRO Continuous Glucose Monitor|DEVICE: Patient mHealth app linked to a provider dashboard|BEHAVIORAL: Care team coaching for medical and social needs (HUB)|DEVICE: Provider dashboard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Glutaminase Inhibitor CB-839 in Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors|Triple-Negative Breast Cancer|Non Small Cell Lung Cancer|Renal Cell Carcinoma|Mesothelioma|Fumarate Hydratase (FH)-Deficient Tumors|Succinate Dehydrogenase (SDH)-Deficient Gastrointestinal Stromal Tumors (GIST)|Succinate Dehydrogenase (SDH)-Deficient Non-gastrointestinal Stromal Tumors|Tumors Harboring Isocitrate Dehydrogenase-1 (IDH1) and IDH2 Mutations|Tumors Harboring Amplifications in the cMyc Gene
Interventions: DRUG: CB-839|DRUG: Pac-CB|DRUG: CBE|DRUG: CB-Erl|DRUG: CBD|DRUG: CB-Cabo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Mindfulness-based Breath Training and Heart Rate Variability Biofeedback for Shoulder Surgery Patients in the Postoperative Pain.
Status: RECRUITING
Conditions: Pain, Postoperative|Shoulder Pain
Interventions: BEHAVIORAL: Mindfulness-based breathing|BEHAVIORAL: HRV biofeedback|BEHAVIORAL: cognitive-behavioral pain psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Soy Protein on Serum paraoxonase1 Activity and Lipoproteins in Postmenopausal Women
Status: COMPLETED
Conditions: Postmenopausal|Hyperlipidemia
Interventions: PROCEDURE: soy consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Prospective Random Comparing Study on EUS-guided Pseudocyst Drainage by Naso-pancreatic Tube and Stents
Status: UNKNOWN
Conditions: Pancreatic Pseudocyst
Interventions: PROCEDURE: EUS-guided pancreatic pseudocyst drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trigonal vs Non Trigonal Botox Injection in OAB.
Status: COMPLETED
Conditions: Urologic Diseases|Overactive Bladder Syndrome|Quality of Life|Anticholinergic Syndrome
Interventions: DRUG: botulinum toxin A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketofol for Preventing Postoperative Delirium in Elderly Patients
Status: COMPLETED
Conditions: Delirium on Emergence
Interventions: DRUG: ketofol|DRUG: dexmedetomidine|OTHER: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Interest of the 7 Tesla MRI in the Diagnosis of Post-concussion Syndromes Among Patients With Mild Traumatic Brain Injury
Status: RECRUITING
Conditions: Post-Concussion Syndrome
Interventions: OTHER: 7T MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Medial Rectus Resection and Plication in Exotropic Patients
Status: UNKNOWN
Conditions: Exotropia
Interventions: PROCEDURE: Plication strabismus surgery|PROCEDURE: Resection strabismus surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Oxygen Savings With Administered Oxygen and High Flow Ambient Air At Rest
Status: RECRUITING
Conditions: Pulmonary Disease, Chronic Obstructive|Lung Diseases, Interstitial|Pulmonary Fibrosis|Hypoxemia|Dyspnea|Oxygen Inhalation Therapy
Interventions: DEVICE: Nasal Delivery of High-Flow Air and Oxygen Therapy|DEVICE: Nasal Delivery of Oxygen Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ProMRI Study of the Entovis Pacemaker System
Status: COMPLETED
Conditions: Safety of the ProMRI Pacemaker System Under Specific MRI Conditions
Interventions: DEVICE: Patients with a ProMRI Pacemaker System|OTHER: Magnetic Resonance Imaging (MRI) scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of an Adjuvanted RSV Vaccine in Healthy Older Adults
Status: TERMINATED
Conditions: Respiratory Tract Infection
Interventions: BIOLOGICAL: Formulation A|BIOLOGICAL: Formulation B|BIOLOGICAL: Formulation C|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lasmiditan Compared to Placebo in the Acute Treatment of Migraine in Korean
Status: COMPLETED
Conditions: Acute Migraine
Interventions: DRUG: Lasmiditan 50mg|DRUG: Lasmiditan 100mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tofacitinib as a GC Sparing Agent for Polymyalgia Rheumatica
Status: COMPLETED
Conditions: Polymyalgia Rheumatica|Effect of Drug|Safety Issues
Interventions: DRUG: Tofacitinib 5 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ObeSity Related Colorectal Adenoma Risk
Status: COMPLETED
Conditions: Colorectal Adenoma|Colorectal Neoplasm|Colorectal Cancer|Obesity|Metabolic Syndrome|Non-Alcoholic Fatty Liver Disease|Liver Fibrosis
Interventions: DIAGNOSTIC_TEST: Colonoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Albumin Plus Midodrine v/s Albumin Alone in Reducing Incidence of Paracentesis Induced Circulatory Dysfunctions in ACLF Patients.
Status: UNKNOWN
Conditions: Acute-On-Chronic Liver Failure
Interventions: BIOLOGICAL: Albumin|DRUG: Midodrine Oral Tablet|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: SU5416 in Treating Patients With Advanced, Metastatic, or Recurrent Soft Tissue Sarcomas
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumor|Sarcoma
Interventions: DRUG: semaxanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2b Study of CSL112 in Subjects With Acute Myocardial Infarction.
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: BIOLOGICAL: CSL112|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Biomarker for Glycogen Storage Diseases (BioGlycogen)
Status: WITHDRAWN
Conditions: Fructose Metabolism, Inborn Errors|Glycogen Storage Disease|Glycogen Storage Disease Type I|Glycogen Storage Disease Type II|Glycogen Storage Disease Type III|Glycogen Storage Disease Type IV|Glycogen Storage Disease Type V|Glycogen Storage Disease Type VI|Glycogen Storage Disease Type VII|Glycogen Storage Disease Type VIII
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of a New Device "Orthèse Diabète" in the Healing of Foot Ulcers in Diabetic Patients
Status: COMPLETED
Conditions: Foot Ulcer, Diabetic
Interventions: DEVICE: Orthèse Diabète|DEVICE: "Conventional" Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bay1002670, Fibroids, Safety and Efficacy EU,US,Can, Jap
Status: COMPLETED
Conditions: Leiomyoma
Interventions: DRUG: BAY1002670|DRUG: BAY1002670|DRUG: BAY1002670|DRUG: BAY1002670|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Perineural Injection Therapy Versus Steroid in Patients With Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: DRUG: 5% dextrose|DRUG: 1cc 2% Xylocaine+4cc Triamcinolone (40mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of the Perioperative Hemodynamic Effects of Remifentanil and Esmolol in Intracranial Surgery
Status: COMPLETED
Conditions: Tachycardia|Hypertension|Myocardial Ischemia
Interventions: DRUG: Esmolol|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gefitinib With Anlotinib in Advanced Non-squamous NSCLC Patients With Uncleared Plasma ctDNA EGFRm After First-line Treatment With Gefitinib
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer|EGFR Gene Mutation
Interventions: DRUG: Gefitinib|DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IVUS Guided PCI for CKD to Reduce CI-AKI
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease|Chronic Kidney Diseases
Interventions: BEHAVIORAL: IVUS based ultralow contrast PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Type 1 Diabetes
Status: RECRUITING
Conditions: Type 1 Diabetes
Interventions: COMBINATION_PRODUCT: Co-transplantation of PTG with pancreatic islets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug-drug Interaction Study Between Daclatasvir and Metformin
Status: COMPLETED
Conditions: Hepatitis C|Diabetes Mellitus|Insulin Resistance
Interventions: DRUG: Daclatasvir|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Exercise Dose-Response Effects in Prediabetes
Status: COMPLETED
Conditions: Pre-Diabetes
Interventions: BEHAVIORAL: Aerobic Exercise|BEHAVIORAL: Aerobic Exercise|BEHAVIORAL: Aerobic Exercise|BEHAVIORAL: Exercise and Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Are There Protective Effects of Antioxidants, Calcium Channel Blocker and Angiotensin Receptor Blocker Against Extracorporeal Shockwaves Lithotripsy Induced Renal Injury?
Status: COMPLETED
Conditions: Kidney Calculi
Interventions: DRUG: Antioxidant group|DRUG: Calcium Channel Blockers|DRUG: Angiotensin receptor blocker group|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Pilot RCT to Investigate the Use of a Home-based Nintendo Wii Program for Rehabilitation in Older Adults With Lower Limb Amputation
Status: COMPLETED
Conditions: Lower Limb Amputation
Interventions: DEVICE: Wii.n.Walk|DEVICE: Wii Big Brain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia
Status: NOT_YET_RECRUITING
Conditions: Acute Leukemia of Ambiguous Lineage|B Acute Lymphoblastic Leukemia
Interventions: DRUG: Asparaginase Erwinia chrysanthemi|PROCEDURE: Biospecimen Collection|BIOLOGICAL: Blinatumomab|PROCEDURE: Bone Marrow Aspiration|DRUG: Calaspargase Pegol|PROCEDURE: Computed Tomography|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Daunorubicin|DRUG: Dexamethasone|DRUG: Doxorubicin|PROCEDURE: Echocardiography|PROCEDURE: FDG-Positron Emission Tomography|DRUG: Leucovorin|PROCEDURE: Lumbar Puncture|PROCEDURE: Magnetic Resonance Imaging|DRUG: Mercaptopurine|DRUG: Methotrexate|PROCEDURE: Multigated Acquisition Scan|DRUG: Pegaspargase|DRUG: Prednisolone|DRUG: Prednisone|DRUG: Therapeutic Hydrocortisone|DRUG: Thioguanine|DRUG: Venetoclax|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effects of 6R-BH4 on Blood Pressure in Subjects With Poorly Controlled Systemic Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: 6R-BH4 (sapropterin dihydrochloride)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: LiveWell: Adapted DBT Skills Training for Metastatic Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Cancer Metastatic to Lung
Interventions: BEHAVIORAL: LiveWell: Adapted Dialectical Behavioral Therapy Skills Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pilot Study to Assess Theragnostically Planned Liver Radiation to Optimize Radiation Therapy
Status: COMPLETED
Conditions: Liver Cancer|Hepatocellular Carcinoma|Cholangiocarcinoma
Interventions: DIAGNOSTIC_TEST: Hepatobiliary Iminodiacetic Acid (HIDA) scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetic and Safety Study of Cenicriviroc and HMG-CoA Reductase Inhibitors, Caffeine and Digoxin
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rosuvastatin|DRUG: Atorvastatin|DRUG: Simvastatin|DRUG: Digoxin|DRUG: Caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Cohort Study on the Efficacy of Vagus Nerve Stimulation for Children and Adolescents With Epilepsy(PVNS-CAE)
Status: UNKNOWN
Conditions: Epileptic Encephalopathy
Interventions: PROCEDURE: PINS Vagus Nerve Stimulator|DRUG: Levetiracetam
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: cSBIRT to Reduce Teen Tobacco, Alcohol and Drug Use
Status: WITHDRAWN
Conditions: Tobacco Abuse|Alcohol Abuse|Drug Abuse
Interventions: BEHAVIORAL: Computer Screening, Brief Intervention, Referral toTreatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Eight-Week Study to Evaluate the Efficacy and Safety of SR58611A in Patients With Generalized Anxiety Disorder
Status: COMPLETED
Conditions: Anxiety Disorders
Interventions: DRUG: SR58611A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Changes in Skeletal Muscle Proteins Following Resistance Exercise and Single-Leg Disuse
Status: RECRUITING
Conditions: Healthy|Skeletal Muscle Atrophy|Skeletal Muscle Hypertrophy
Interventions: OTHER: Immobilization|OTHER: Resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influence of Dopaminergic Blockade on Stress Responses, Motivation and Emotional Reactivity in Humans.
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Amisulpride 300 MG|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Management of Excess Gingival Display Using Tunnel Technique With 3D Designed PEEK Shell: A Case Series
Status: RECRUITING
Conditions: Excessive Gingival Display
Interventions: OTHER: tunnel technique with a 3D printed PEEK shell to fill the skeletal subnasal depression
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Tiotropium 18 μg Inhalation Powder, Hard Capsule With Spiriva®Handihaler® 18 μg Inhalation Powder, Hard Capsule in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: COPD
Interventions: COMBINATION_PRODUCT: Test Product - Tiotropium Bromide Inhalation Powder 18 mcg|COMBINATION_PRODUCT: Spiriva Handihaler (Tiotropium Bromide) 18 mcg|COMBINATION_PRODUCT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Naloxegol for Opioid-Related Gastroparesis
Status: WITHDRAWN
Conditions: Gastroparesis|Opioid Use
Interventions: DRUG: Naloxegol 25 MG Oral Tablet [Movantik]|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Fasting Blood Glucose Measurements From Fingertip and Intravenous on Patient Satisfaction in Patients With Diabetes Mellitus
Status: RECRUITING
Conditions: Diabetes Mellitus
Interventions: BEHAVIORAL: Patients whose blood glucose is measured intravenously and from the fingertip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Magnetic Resonance Technics for the Assessment of Liver Function Before and After TIPS
Status: RECRUITING
Conditions: Liver Cirrhosis|Transjugular Intrahepatic Portosystemic Shunt (TIPS)|Functional Magnetic Resonance Imaging
Interventions: PROCEDURE: TIPS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Anti-Interleukin-5 (IL5) Monoclonal Antibody (MAb) in Prednisone-dependent Eosinophilic Asthma
Status: COMPLETED
Conditions: Severe Persistent Asthma|Eosinophilic Bronchitis
Interventions: BIOLOGICAL: Reslizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of NeoRecormon (Epoetin Beta), CellCept (Mycophenolate Mofetil) and Prednisone in Patients With Low or Intermediate Myelodysplastic Syndromes.
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Mycophenolate mofetil|DRUG: Prednisone|DRUG: Erythropoietin Beta
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Posterior Capsule Opacification (PCO) With AcrySof Single-Piece IOL
Status: COMPLETED
Conditions: Posterior Capsule Opacification
Interventions: PROCEDURE: Phaco
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial Comparing Immediate vs. Deferred Surgery for Symptomatic ERM
Status: RECRUITING
Conditions: Epiretinal Membrane
Interventions: PROCEDURE: Immediate Vitrectomy|PROCEDURE: Deferred Vitrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Bilateral Superficial Cervical Block for Post-operative Pain Therapy in Thyroid Surgery
Status: UNKNOWN
Conditions: Bilateral Superficial Cervical Block
Interventions: DRUG: bupivacaine|DRUG: Dexamethasone|DEVICE: ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SWOG-8814 Tamoxifen With or Without Combination Chemotherapy in Postmenopausal Women Who Have Undergone Surgery for Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: endocrine therapy|DRUG: endocrine-modulating drug therapy|DRUG: fluorouracil|DRUG: tamoxifen citrate|RADIATION: brachytherapy|RADIATION: low-LET electron therapy|RADIATION: low-LET photon therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Novel Non Invasive Brain Stimulation Based Treatment for Chronic Low Back Pain (CLBP)
Status: UNKNOWN
Conditions: Chronic Low Back Pain
Interventions: DEVICE: Neuroelectrics STARSTIM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Envafolimab Alone or With Lenvatinib in Patients With Advanced Endometrial Cancer
Status: RECRUITING
Conditions: Advanced Endometrial Cancer
Interventions: DRUG: Envafolimab+Lenvatinib|DRUG: Envafolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Removing Transfusion Dependence as a Barrier to Hospice Enrollment
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematologic Malignancy|Myelodysplastic Syndromes|Acute Myeloid Leukemia|Lymphoma|Leukemia|Myeloma
Interventions: OTHER: Transfusion support
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Efficacy and Safety of FX006 in Patients With Glenohumeral Osteoarthritis or Shoulder Adhesive Capsulitis
Status: TERMINATED
Conditions: Osteoarthritis of the Shoulder|Adhesive Capsulitis
Interventions: DRUG: FX006|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Mealtime Insulin LY900014 in Participants With Type 2 Diabetes Using Continuous Glucose Monitoring (PRONTO-Time in Range)
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: LY900014|DRUG: Insulin Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shoulder Instability Trial Comparing Arthroscopic Stabilization Benefits Compared With Latarjet Procedure Evaluation
Status: ACTIVE_NOT_RECRUITING
Conditions: Shoulder Dislocation|Sport Injuries|Shoulder|Anterior Dislocation
Interventions: PROCEDURE: Latarjet Procedure|PROCEDURE: Bankart + Remplissage Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Mu-opioid Receptor Genetics on 3 Doses of Spinal Morphine for Postoperative Analgesia After Cesarean Section
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra Incisional Infiltration of Bupivacaine Versus Meloxicam on Post Cesarean Section Pain Relief
Status: COMPLETED
Conditions: Cesarean Section Pain
Interventions: DRUG: local ifiltration Bupivacaine, Meloxican and placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Retrospective Multicenter Comparison of Laparoscopic and Robotic-Assisted Roux-en-Y Gastrectomy
Status: RECRUITING
Conditions: Laparoscopic Sleeve Gastrectomy|Sleeve Gastrectomy
Interventions: PROCEDURE: Roux-en-Y Gastric Bypass|PROCEDURE: Sleeve Gastrectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cognitive-behavioral Intervention Via a Smartphone App for Depressive Symptoms in Caregivers
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Multicomponent Cognitive Behavioral Intervention administered via a smartphone App (CCIA)|BEHAVIORAL: Multicomponent Cognitive Behavioral Intervention administered via a smartphone App+ telephone contact via conference call (CCIA+CC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Fasting on Success Rates of Assisted Reproductive Techologies
Status: TERMINATED
Conditions: Sub Fertility, Female|Fertility Disorders|Fertility Issues|Sub-fertility|IVF
Interventions: BEHAVIORAL: Fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GABA Treatment in Subjects With Type 1 Diabetes
Status: UNKNOWN
Conditions: Type 1 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Gama amino butyric acid (GABA)|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pembrolizumab in Locally Advanced Sinonasal Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Sinonasal Undifferentiated Carcinoma
Interventions: DRUG: Pembrolizumab|DRUG: Cisplatin|DRUG: Docetaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Erlotinib in Treating Patients With Advanced Liver Cancer
Status: COMPLETED
Conditions: Adult Primary Hepatocellular Carcinoma|Advanced Adult Primary Liver Cancer|Localized Unresectable Adult Primary Liver Cancer|Recurrent Adult Primary Liver Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: erlotinib hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Paroxetine Daily Doses of 15 mg and 20 mg in the Treatment of Premature Ejaculation
Status: COMPLETED
Conditions: Premature Ejaculation
Interventions: DRUG: paroxetine|DRUG: paroxetine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Vitamin B12 in Septic Shock
Status: RECRUITING
Conditions: Septic Shock
Interventions: DRUG: Hydroxocobalamin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT