pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Controlled evaLuation of Angiotensin Receptor Blockers for COVID-19 respIraTorY Disease
Status: COMPLETED
Conditions: Coronavirus Disease 2019|COVID-19
Interventions: DRUG: Angiotensin Receptor Blockers|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endocrowns as Permanent Restorations for Endodontically Treated Permanent Molars in Young Age: Two-Year Follow up
Status: COMPLETED
Conditions: Endodontically Treated Teeth|Permanent Molars
Interventions: OTHER: Control group|OTHER: Endocrown group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Hidden Impairments During Subarachnoid Haemorrhage Recovery, Description and Evolution of a Newly Described Syndrom
Status: NOT_YET_RECRUITING
Conditions: Intracranial Hemorrhages
Interventions: OTHER: questionnaire|OTHER: SS-QoL|OTHER: SF-36|OTHER: CIQ-R|DIAGNOSTIC_TEST: BREFF|DIAGNOSTIC_TEST: MoCA|OTHER: IADL|OTHER: mMRS|OTHER: PCL-5|OTHER: Brief-Cope
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Revascularization Strategy of Multivessel Disease for Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock Undergoing Veno-arterial Extracorporeal Membrane Oxygenator
Status: RECRUITING
Conditions: Cardiogenic Shock|Acute Myocardial Infarction|Multi Vessel Coronary Artery Disease|Extracorporeal Membrane Oxygenation
Interventions: PROCEDURE: Culprit lesion only PCI|PROCEDURE: Immediate multi-vessel PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Impact of SomaSignal Tests on Medical Management and Change in Risk in Patients at Higher Risk of Cardiovascular Disease: A Feasibility and an Adaptive Implementation Study
Status: RECRUITING
Conditions: Health Behavior
Interventions: OTHER: SomaSignal Test Results
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Bridging Trial Comparing Sugammadex (Org 25969) at Reappearance of T2 in Japanese and Caucasian Participants. Part B: Caucasian Participants (P05971)
Status: COMPLETED
Conditions: Anesthesia, General
Interventions: DRUG: Sugammadex|DRUG: Placebo|DRUG: Rocuronium|DRUG: Vecuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of an Educational Intervention in the Beliefs and Attitudes of Primary Care Professionals
Status: UNKNOWN
Conditions: Chronic Nonspecific Low Back Pain
Interventions: OTHER: Educational intervention|OTHER: Video explaining the clinical practice guidelines on low back pain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of TBI-2001(Autologous CD19 Specific Chimeric Antigen Receptor (CAR) Gene-transduced T Lymphocytes) for Relapsed or Refractory CD19+ B-cell Lymphoma, CLL/SLL
Status: RECRUITING
Conditions: Relapsed or Refractory CD19+ B-cell Lymphoma|Relapsed or Refractory Chronic Lymphocytic Leukemia|Relapsed or Refractory Small Lymphocytic Lymphoma
Interventions: BIOLOGICAL: TBI-2001|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expression of IRAK1 Gene rs1059703-related Single- Nucleotide Polymorphisms in Egyptian Patient With Rheumatoid Arthritis
Status: RECRUITING
Conditions: Rheumatoid Arthritis (RA)
Interventions: GENETIC: PCR polymorphism
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical and Morphological Characteristics of Chronic Inflammation in the Myocardium in Patients With Decompensated HF With Ischemic Systolic Dysfunction
Status: UNKNOWN
Conditions: Decompensated Heart Failure|Ischemic Heart Disease
Interventions: PROCEDURE: Endomyocardial biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Split-dose Versus Single-dose Polyethylene Glycol Regimen for Capsule Endoscopy
Status: UNKNOWN
Conditions: Bowel Preparation
Interventions: DEVICE: Capsule endoscopy|DRUG: Polyethylene Glycol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacodynamic Drug Interaction Between Warfarin and Amoxicillin-clavulanic Acid
Status: COMPLETED
Conditions: Oral Anticoagulation|Deep Venous Thrombosis|Atrial Fibrillation|Pulmonary Embolism
Interventions: DRUG: Firstly : Amoxicillin-Clavulanic acid and secondly : Placebo|DRUG: Firstly : Placebo and secondly : Amoxicillin-Clavulanic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial of ImpACT+, a Coping Intervention for HIV Infected Women With Sexual Trauma in South Africa
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV|Trauma Exposure
Interventions: BEHAVIORAL: Improving AIDS Care After Trauma +|BEHAVIORAL: Adapted Problem-Solving Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integral Clinical Plan Shared With or Without Telemonitoring of Constants in Patient With Chronic Diseases
Status: UNKNOWN
Conditions: Chronic Lung Disease|Chronic Heart Disease
Interventions: OTHER: Telemonitoring Constant|OTHER: Standard clinical care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: MUC1 Vaccine in Preventing Lung Cancer in Current and Former Smokers at High Risk for Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: MUC1 Peptide-Poly-ICLC Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Novel Locator-Positioner Device for Temporomandibular Joint Arthroscopy
Status: COMPLETED
Conditions: Temporomandibular Joint Disc Displacement|Temporomandibular Joint Disorders|Temporomandibular Joint Dysfunction Syndrome
Interventions: DEVICE: Locator-Positioner (LOPO) Guide Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Remimazolam vs Propofol as an Induction Agent for Morbid Obesity Patients
Status: RECRUITING
Conditions: Remimazolam|Desflurane|Morbid Obesity|Sleeve Gastrectomy|General Anesthesia
Interventions: DRUG: Remimazolam besylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Use of Dexamethasone in Uterine Artery Embolization
Status: COMPLETED
Conditions: Uterine Myoma|Adenomyosis
Interventions: DRUG: Dexamethasone|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Randomized Study of Beta-Blockers and Antiplatelets in Patients With Spontaneous Coronary Artery Dissection
Status: NOT_YET_RECRUITING
Conditions: Spontaneous Coronary Artery Dissection
Interventions: DRUG: Beta blocker, aspirin, clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Chlorhexidine Gluconate as a Preoperative Antisepsis
Status: COMPLETED
Conditions: Surgical Site Infection
Interventions: DRUG: Povidone-Iodine|DRUG: Chlorhexidine gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fractional Laser in Combination With UVB Therapy in Vitiligo Patients
Status: WITHDRAWN
Conditions: Vitiligo
Interventions: DEVICE: Fractional CO2 laser|OTHER: NB-UVB therapy|DRUG: Fluticasone Propionate Cream 0.05%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketamine Continuous Infusion on Opioid Consumption and Pain Management in Severe Burned Patients
Status: WITHDRAWN
Conditions: Pain, Burning
Interventions: DEVICE: Ketamine continuous infusion|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of the Sustainable Diet on Gut Microbiota and the Metabolome: a Randomised Crossover Study
Status: COMPLETED
Conditions: Microbiota|Nutrition, Healthy
Interventions: OTHER: Plant-based diet|OTHER: Western diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Exploratory Study to Evaluate the Efficacy of an Occlusion Based Dentifrice in Relief of Dentinal Hypersensitivity
Status: COMPLETED
Conditions: Dentinal Hypersensitivity
Interventions: DRUG: 5% calcium sodium phosphosilicate/ sodium monofluorophosphate dentifrice|DRUG: 0% calcium sodium phosphosilicate/ sodium monofluorophosphate dentifrice|DRUG: Sodium monofluorophosphate dentifrice|DRUG: Sodium Fluoride dentifrice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)
Status: NOT_YET_RECRUITING
Conditions: Adult Growth Hormone Deficiency|Mild Traumatic Brain Injury
Interventions: DRUG: Somatropin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HA Residents With PVD, SDB Assessed at HA (2840m) vs LA (Sea Level)
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Vascular Disease|Pulmonary Artery Hypertension|Chronic Thromboembolic Pulmonary Hypertension
Interventions: OTHER: Assessment without intervention at High altitude|OTHER: Relocation to sea level for 2 days
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gait Training Combined With Behavioral Strategies for People With Stroke
Status: COMPLETED
Conditions: Stroke|Gait, Hemiplegic|Behavior and Behavior Mechanisms
Interventions: COMBINATION_PRODUCT: Treadmill training + transfer package (TT+TP)|DEVICE: Treadmill training (TT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The ConnectedCancerCare Pilot Study (CCC)
Status: COMPLETED
Conditions: Early-stage Breast Cancer|Breast Cancer Female|Survivorship|Cancer Survivors|Transitional Care
Interventions: BEHAVIORAL: CCC website|BEHAVIORAL: Static care plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: QUILT-3.063: A Study of N-803, haNK and Avelumab in Patients With Merkel Cell Carcinoma That Has Progressed After Checkpoint Therapy
Status: TERMINATED
Conditions: Merkel Cell Carcinoma
Interventions: BIOLOGICAL: Avelumab|BIOLOGICAL: N-803|BIOLOGICAL: haNK™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Trigeminal and Vagus Nerve Stimulation for Stroke Subjects With Chronic Upper Extremity Deficits
Status: RECRUITING
Conditions: Stroke, Ischemic|Upper Extremity Paresis
Interventions: DEVICE: NeuraStasis Stimulator System (Non-Invasive Trigeminal and Vagus Nerve Stimulation)|OTHER: Upper Limb Rehabilitation|OTHER: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tubeless Percutaneous Nephrolithotomy Without Reverse Insertion of a Ureteral Catheter
Status: RECRUITING
Conditions: Urinary Calculi|Percutaneous Nephrolithotomy
Interventions: PROCEDURE: Without reverse insertion of a ureteral catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Nerve Stimulation Using a TENS to Provide Pain Relief During Surgery for Overactive Bladder
Status: COMPLETED
Conditions: Urinary Incontinence|Overactive Bladder|Pain, Acute
Interventions: PROCEDURE: TENS|PROCEDURE: Control TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketamine With Multilevel Paravertebral Block for Post Video-assisted Thoracic Surgery Pain
Status: COMPLETED
Conditions: Pain, Acute|Pain, Chronic|Pain, Neuropathic
Interventions: DRUG: Ketamine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Interleukine 6 (and Other Cytokines and Inflammatory Markers) in COVID-19 Patients With a Systemic Inflammatory Response Syndrome
Status: COMPLETED
Conditions: COVID-19
Interventions: DIAGNOSTIC_TEST: Cytokines dosage|DIAGNOSTIC_TEST: Complement dosage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Efficacy and Safety Study of PENTASA in Chinese Patients With Left-sided Active Ulcerative Colitis Followed by a 24-Week Open-Label Extension Phase
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Mesalazine Enema|DRUG: Placebo Enema
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Acupoint Injection for Primary Dysmenorrhea
Status: COMPLETED
Conditions: Dysmenorrhea|Pain, Menstrual
Interventions: OTHER: Vitamin K acupoint injection|OTHER: Saline Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Keeping Stable Inflammatory Arthritis Patients in Their Communities With the Advanced Clinician Practitioner in Arthritis Care
Status: TERMINATED
Conditions: Inflammatory Arthritis
Interventions: OTHER: Video Conferencing with Exteneded Role Practitioner (VC-ERP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact of Cardiac Coherence on Anxiety in Patients Operated on for a Peritoneal Carcinosis
Status: RECRUITING
Conditions: Peritoneal Carcinomatosis|Pseudomyxoma Peritonei|Mesothelioma Peritoneum
Interventions: OTHER: Cardiac coherence|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Alginate-based Reflux Suppressant and Magnesium-aluminium Antacid Gel for Treatment of Heartburn in Pregnancy
Status: COMPLETED
Conditions: Heartburn in Pregnancy
Interventions: DRUG: Alginate-based reflux suppressant|DRUG: magnesium-aluminium antacid gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of TBS on 5-HT1A Receptor Binding
Status: UNKNOWN
Conditions: Treatment Resistant Depression
Interventions: DEVICE: theta-burst stimulation using a MagPro X1000|DEVICE: sham stimulation using a MagPro X1000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment
Status: COMPLETED
Conditions: Muscle Spasticity
Interventions: DRUG: botulinum A toxin|DRUG: Baclofen|DRUG: Placebo toxin|DRUG: placebo baclofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preventing Metabolic Side Effects of Thiazide Diuretics With KMgCitrate
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Potassium Magnesium Citrate (KMgCit)|DRUG: Potassium Chloride (KCl)|DRUG: Chlorthalidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating the Efficacy of Maintenance Olaparib and Cediranib or Olaparib Alone in Ovarian Cancer Patients
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: DRUG: Olaparib|DRUG: Cediranib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention to Reduce Sugar-Sweetened Beverage (SSB) Consumption in Children and Families
Status: COMPLETED
Conditions: Obesity, Childhood
Interventions: BEHAVIORAL: Pilot Intervention to reduce SSB consumption in children and families
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Decitabine Plus mBU/CY for High Risk Acute Leukemia With MRD Pre-HSCT
Status: RECRUITING
Conditions: Stem Cell Transplant Complications|Leukemia, Myeloid, Acute|Leukemia Relapse
Interventions: DRUG: Decitabine|DRUG: mBU/CY and ATG|DRUG: mBU/CY
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pregnancy, Arsenic and Immune Response
Status: COMPLETED
Conditions: Arsenic--Toxicology|Immunologic Disorders Complicating Pregnancy|Vaccine Response Impaired|Micronutrient Deficiency|Influenza
Interventions: BIOLOGICAL: Seasonal influenza vaccine - VAXIGRIP TETRA influenza vaccine (quadrivalent, split virion, inactivated)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: NOMAC : New Tools for Managing the Fate of Cereal Nutrients in the Gut : Effects of Amylose Content on Glycemic Index.
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: 20% amylose bread|DIETARY_SUPPLEMENT: 10% amylose bread|DIETARY_SUPPLEMENT: Carbohydrates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Early Feasibility Study 2 of Outpatient Control-to-Range - Testing System Efficacy (Italy)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DEVICE: Diabetes Assistant (DiAs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Effects of Daily Administration of Pioglitazone on Brain Hemodynamics in Healthy Elderly Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pioglitazone|DRUG: Pioglitazone|DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Research Study Looking at How 50 mg Semaglutide Daily Affects Food Intake and Emptying of the Stomach in People With Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Semaglutide D Dose 1|DRUG: Semaglutide D Dose 2|DRUG: Semaglutide D Dose 3|DRUG: Semaglutide C Dose 4|DRUG: Semaglutide C Dose 5 (50 mg)|DRUG: Placebo (Semaglutide C)|DRUG: Placebo ( Semaglutide D)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Incision Laparoscopic Surgery (SILS) Versus Conventional Laparoscopic Hysterectomy
Status: UNKNOWN
Conditions: Uterine Myoma|Uterine Adenomyosis
Interventions: PROCEDURE: Single incision Laparoscopic hysterectomy|PROCEDURE: Conventional laparoscopic hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaginal Misoprostol and Dinoprostone Prior to Copper Intrauterine Device Insertion in Women
Status: UNKNOWN
Conditions: IUCD Complication
Interventions: DRUG: dinoprostol|DRUG: misoprostol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hetrombopag for the Enhancement of Platelet Engraftment After Allogeneic Hematopoietic Stem Cell Transplantation
Status: RECRUITING
Conditions: Hematological Disease|Allogeneic Hematopoietic Stem Cell Transplantation
Interventions: DRUG: Hetrombopag|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phenylephrine Infusion in Cesarean Delivery
Status: UNKNOWN
Conditions: Cesarean Section Complications|Spinal Anesthesia
Interventions: DRUG: single shot phenylephrine|DRUG: fixed infusion phenylephrine|DRUG: variable infusion phenylephrine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Evaluate Ezetimibe/Simvastatin and Niacin (Extended Release Tablet) in Patients With Type IIa or Type IIb Hyperlipidemia (0653A-091)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Comparator: ezetimibe/simvastatin + niacin (ER)|DRUG: Comparator: Placebo to ezetimibe/simvastatin|DRUG: Comparator: niacin (ER) tablet|DRUG: Comparator: ezetimibe (+) simvastatin|DRUG: Comparator: Placebo to Niacin (ER)|DRUG: Comparator: ezetimibe/simvastatin and niacin (ER)|DRUG: Comparator: ezetimibe and simvastatin|DRUG: Comparator: Placebo to niacin (ER)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Different Anti-Thrombotic Strategies on Device-Related Thrombosis Prevention After Percutaneous Left Atrial Appendage Occlusion
Status: UNKNOWN
Conditions: Device-Related Thrombosis|Atrial Fibrillation|Left Atrial Appendage Occlusion
Interventions: DRUG: ASA plus Clopidogrel|DRUG: Genetic-Tailored AntiThrombotic Strategy|DRUG: Half-Dose of novel OAC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Chemoradiotherapy Plus Tislelizumab Followed by TME for LARC.
Status: RECRUITING
Conditions: Colorectal Neoplasms
Interventions: COMBINATION_PRODUCT: long course radiotherapy + capecitabine + PD-1 monoclonal antibody treatment combinations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Ovarian Epithelial|Ovarian Neoplasms|Ovarian Cancer|Ovarian Serous Adenocarcinoma|Fallopian Tube Neoplasms|Fallopian Tube Adenocarcinoma|Fallopian Tube Serous Adenocarcinoma|Peritoneal Cancer|Peritoneal Carcinoma|Peritoneal Neoplasms
Interventions: BIOLOGICAL: Oregovomab|DRUG: Paclitaxel|DRUG: Carboplatin|BIOLOGICAL: Placebo|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability and Antitumor Activity of X4P-001 in Combination With TNBC
Status: UNKNOWN
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: X4P-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Transcutaneous Nerve Stimulation for OAB
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: OTHER: Transcutaneous tibial nerve stimulation|OTHER: Sham transcutaneous tibial nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Subjects With Parkinson's Disease to Evaluate the Safety and Tolerability of Titration and Continuous Subcutaneous Infusion of ABBV-951 in an Outpatient Environment
Status: COMPLETED
Conditions: Parkinson's Disease (PD)
Interventions: DRUG: ABBV-951
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omacetaxine Mepesuccinate, Cytarabine, and Decitabine in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Secondary Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: cytarabine|DRUG: omacetaxine mepesuccinate|DRUG: decitabine|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Therapeutic Effects of Greater Occipital Nerve Block, Topiramate, and Flunarizine on Episodic Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: PROCEDURE: Greater Occipital Nerve Block|DRUG: Topiramate|DRUG: Flunarizine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: I2PETHV - Imidazoline2 Binding Site in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers|Alzheimer Disease|Molecular Imaging
Interventions: RADIATION: [11C]BU99008|DRUG: Idazoxan|DRUG: Isocarboxazid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An fMRI Study of Stimulant vs. Non-Stimulant Treatment of ADHD
Status: TERMINATED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Guanfacine|DRUG: Lisdexamfetamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK and PD Study of IDN-6556 in Subjects With Severe Renal Impairment and Matched Healthy Volunteers
Status: COMPLETED
Conditions: Renal Impairment|Renal Insufficiency|Kidney Disease|Kidney Diseases
Interventions: DRUG: IDN-6556
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk-guided Disease Management in Coronary Artery Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease|Chronic Disease|Nurse's Role
Interventions: BEHAVIORAL: Risk-Guided DMP|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Artificial Lighting on Affective and Core Symptoms of Eating Disorder
Status: TERMINATED
Conditions: Anorexia Nervosa|Eating Disorder
Interventions: OTHER: Circadian Lighting regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate 3 Different Doses of JNJ-31001074 in the Treatment of Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Atomoxetine 80 mg/d|DRUG: Placebo|DRUG: OROS methylphenidate HCl 54 mg/d|DRUG: JNJ-31001074 3 mg/d|DRUG: JNJ-31001074 1 mg/d|DRUG: JNJ-31001074 10 mg/d
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stent Placement With or Without Photodynamic Therapy Using Porfimer Sodium as Palliative Treatment in Treating Patients With Stage III or Stage IV Cholangiocarcinoma That Cannot Be Removed By Surgery
Status: WITHDRAWN
Conditions: Cholangiocarcinoma of the Extrahepatic Bile Duct|Cholangiocarcinoma of the Gallbladder|Unresectable Extrahepatic Bile Duct Cancer|Unresectable Gallbladder Cancer|Recurrent Extrahepatic Bile Duct Cancer|Recurrent Gallbladder Cancer
Interventions: DRUG: porfimer sodium|PROCEDURE: adjuvant therapy|PROCEDURE: laser therapy|PROCEDURE: photodynamic therapy|PROCEDURE: phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: StrataXRT vs Standard Clinical Practice for the Prevention of Acute Dermatitis in Head and Neck Cancers Patients
Status: UNKNOWN
Conditions: Head and Neck Cancers|Acute Radiation Dermatitis
Interventions: DEVICE: StrataXRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Multifocal Electroretinogram Assessment in Chronic Central Serous Chorioretinopathy (CSC) Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy
Status: COMPLETED
Conditions: Central Serous Chorioretinopathy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Hypotensive Anesthesia on Cerebral Perfusion and Blood Antioxidant Levels and HIF 1a
Status: COMPLETED
Conditions: Hypoxemia During Surgery|Hypoxia, Brain
Interventions: PROCEDURE: systolic blood pressure (SBP)|PROCEDURE: mean blood pressure (MBP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Safety and Pharmacokinetics Study of MBX 2109 in Adult Subjects With Normal and Impaired Renal Function
Status: RECRUITING
Conditions: Renal Impairment
Interventions: DRUG: MBX 2109|DRUG: MBX 2109|DRUG: MBX 2109|DRUG: MBX 2109
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part I
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypothermia|Immature Newborn
Interventions: PROCEDURE: Resuscitation-torso plastic bag|PROCEDURE: Resuscitation-partial-head plastic bag
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Triple Chamber Pacing in Hypertrophic Obstructive Cardiomyopathy (HOCM) Patients - TRICHAMPION STUDY
Status: COMPLETED
Conditions: Hypertrophic Cardiomyopathy With Obstruction
Interventions: DEVICE: CRT-P Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment for Speech and Language in Primary Progressive Aphasia
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Progressive Aphasia|Semantic Dementia|Semantic Memory Disorder|Logopenic Progressive Aphasia|Nonfluent Aphasia, Progressive|Aphasia|Aphasia, Progressive
Interventions: BEHAVIORAL: Lexical Retrieval Training (LRT)|BEHAVIORAL: Video-Implemented Script Training for Aphasia (VISTA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Evaluate the Safety and Tolerability of TT-01488 in Patients With B-Cell Malignancies
Status: RECRUITING
Conditions: B-Cell Malignancies
Interventions: DRUG: TT-01488 Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementing Hypertension Screening Guidelines in Primary Care
Status: UNKNOWN
Conditions: Hypertension,Essential|White Coat Hypertension
Interventions: BEHAVIORAL: Multifaceted Implementation Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Immunogenicity of 3 Lots of GSK Biologicals' HBV-MPL Vaccine and Engerix™-B in Healthy Volunteers ≥ 15y
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: HBV-MPL vaccine 208129|BIOLOGICAL: Engerix™-B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Pilot Study on the Use of Platelet Rich Plasma (PRP) for Facial and Hand Skin Rejuvenation
Status: COMPLETED
Conditions: Skin Aging of Face and Hands
Interventions: BIOLOGICAL: Platelet Rich Plasma|BIOLOGICAL: Platelet Rich Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Modakafusp Alfa (TAK-573) Given by Itself and Together With Pembrolizumab in Adults With Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Neoplasms|Melanoma
Interventions: DRUG: Modakafusp Alfa|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impact of Probiotics on Urinary Symptoms in Spinal Cord Injury SCI and SB
Status: COMPLETED
Conditions: Lower Urinary Tract Symptoms
Interventions: DRUG: Lactobacillus rhamnosus GG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Oral Cleft Prevention Program
Status: COMPLETED
Conditions: Cleft Lip|Cleft Palate
Interventions: DRUG: Folic acid: 4 mg versus 0.4 mg per day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Chimpanzee Adenovirus and Self-Amplifying mRNA Prime-Boost Prophylactic Vaccines Against SARS-CoV-2 in Healthy Adults
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: ChAdV68-S|BIOLOGICAL: ChAdV68-S-TCE|BIOLOGICAL: SAM-LNP-S|BIOLOGICAL: SAM-LNP-S-TCE|OTHER: Sodium Chloride, 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A DOSE-RANGING STUDY TO EVALUATE EFFICACY AND SAFETY OF PF-06700841 IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Placebo|DRUG: PF-06700841 15 mg|DRUG: PF-06700841 30 mg|DRUG: PF-06700841 45 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pregabalin Versus Placebo In The Treatment Of Neuropathic Pain Associated With HIV Neuropathy
Status: TERMINATED
Conditions: Neuropathy
Interventions: DRUG: pregabalin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rucaparib Plus Ramucirumab With or Without Nivolumab in Advanced Gastric and Esophageal Adenocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophagus Cancer, Adenocarcinoma|Stomach Cancer, Adenocarcinoma
Interventions: DRUG: Rucaparib|DRUG: Ramucirumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Cannabidiol Oil on Pain After Ureteroscopy for Kidney Stones
Status: COMPLETED
Conditions: Urinary Stone
Interventions: DRUG: Cannabidiol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Trial Using Bone Marrow-derived Mononuclear Cells for Spinal Cord Injury
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: BIOLOGICAL: Transplantation of autologous bone marrow-derived mononuclear cells by lumbar injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Rapamycin on Communicating Hydrocephalus Secondary to Intraventricular Hemorrhage
Status: RECRUITING
Conditions: Communicating Hydrocephalus|Cerebral Intraventricular Hemorrhage|Secondary Normal Pressure Hydrocephalus|Post Hemorrhagic Hydrocephalus
Interventions: DRUG: Rapamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Intrathecally Administered Magnesium Sulfate
Status: COMPLETED
Conditions: Abdominal Cancer|Abdominal Pain
Interventions: PROCEDURE: intrathecal morphine+LA|PROCEDURE: intrathecal morphine+LA+ Mg sulp. 50|PROCEDURE: intrathecal morphine+LA+ Mg sulp. 100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Safety and Efficacy Study of L-Glutamine to Treat Sickle Cell Disease or Sickle βo-thalassemia
Status: COMPLETED
Conditions: Sickle Cell Anemia|Sickle ß0-Thalassemia
Interventions: DRUG: L-glutamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of 18 mg Selincro® As-needed Use, in the Treatment of Patients With Alcohol Dependence in Primary Care
Status: TERMINATED
Conditions: Alcohol Dependence
Interventions: DRUG: Selincro® 18 mg with continuous psychosocial support: Cohort A|OTHER: Initial psychosocial support: Cohort B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-In-Human Study of STX-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR Exon 20 Insertion Mutations
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer|NSCLC|EGFR/HER2 Exon 20 Insertion Mutation
Interventions: DRUG: STX-721 (Escalated)|DRUG: STX-721 (2 doses)|DRUG: STX-721 (RP2D)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Potential Efficacy of the Chinese Health Improvement Profile- A Pilot Clustered Randomised Controlled Trial
Status: COMPLETED
Conditions: Severe Mental Illness|Schizophrenia|Schizoaffective Disorder|Bipolar Affective Disorder|Cardiovascular Health
Interventions: BEHAVIORAL: Chinese CHIP|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact of Body Weight and Weight Loss on Drug Bioavailability, Cardiovascular Risk Factors and Metabolic Biomarkers
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: PROCEDURE: Gastric bypass|BEHAVIORAL: Very low calorie diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interscalene Block Versus Combined Infraclavicular-Anterior Suprascapular Blocks for Shoulder Surgery
Status: RECRUITING
Conditions: Pain, Postoperative|Shoulder Pain|Surgical Procedure, Unspecified|Diaphragmatic Paralysis
Interventions: PROCEDURE: Interscalene Block|PROCEDURE: Infraclavicular - Anterior Supraescapular Nerve Blocks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dexmedetomidine vs Dexamethasone as Adjuvant to Bupivacaine in Bilevel Erector Spinae Plane Block in Breast Surgeries
Status: RECRUITING
Conditions: Analgesia
Interventions: PROCEDURE: Bilevel Erector spinae plane block|PROCEDURE: Bilateral Erector spinae plane block with dexamethasone|PROCEDURE: Bilateral Erector spinae plane block with dexmedetomidine|DRUG: Intravenous morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: INVESTIGATION OF THE EFFECTS OF BAPNE AND QI GONG EXERCISES ON BALANCE AND QUALITY OF LIFE IN INDIVIDUALS OVER 60
Status: ACTIVE_NOT_RECRUITING
Conditions: Biomechanics, Anatomy, Psychology, Neuroscience, Ethnomusicology Method|qi Gong|Quality of Life|Balance
Interventions: OTHER: bapne|OTHER: qi gong
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioimpedance Analysis Guided Volume Expansion for the Prevention of Contrast Induced-acute Kidney Injury
Status: COMPLETED
Conditions: X-ray Contrast Media Adverse Reaction
Interventions: OTHER: Bioimpedance guided|OTHER: standard hydration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness Comparison of Three Supplementary Foods in the Treatment of Moderate Acute Malnutrition
Status: COMPLETED
Conditions: Malnutrition
Interventions: DIETARY_SUPPLEMENT: Soy/peanut fortified spread|DIETARY_SUPPLEMENT: Milk fortified corn/soy blend|DIETARY_SUPPLEMENT: Supplementary Plumpy®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of BTDS in Subjects With Low Back Pain: A 52-Week Extension Phase of BUP3015
Status: TERMINATED
Conditions: Back Pain Lower Back Chronic
Interventions: DRUG: Buprenorphine transdermal patch|DRUG: Buprenorphine transdermal patch|DRUG: Buprenorphine transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial
Status: RECRUITING
Conditions: Metastatic Malignant Neoplasm in the Bone|Prostate Adenocarcinoma|Stage III Prostate Cancer AJCC v8|Stage IIIA Prostate Cancer AJCC v8|Stage IIIB Prostate Cancer AJCC v8|Stage IIIC Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8
Interventions: DRUG: Apalutamide|DRUG: Bicalutamide|DRUG: Buserelin|DRUG: Degarelix|DRUG: Flutamide|DRUG: Goserelin|DRUG: Histrelin|DRUG: Leuprolide|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Radiation Therapy|DRUG: Triptorelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closed Incision Negative Pressure Wound Therapy for the Prevention of Surgical Site Infections in Abdominal Surgery
Status: NOT_YET_RECRUITING
Conditions: Surgical Wound Infection
Interventions: DEVICE: Closed incision negative pressure wound therapy|DEVICE: Standard dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Micromechanical Modeling Using Low Magnitude Mechanical Stimulation
Status: COMPLETED
Conditions: Bone Alteration
Interventions: DEVICE: Low Magnitude Mechanical Stimulation|DEVICE: Sham Low Magnitude Mechanical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: GnRH Agonist and Antagonists in an Oocyte Donation Program
Status: COMPLETED
Conditions: Effect of Two Protocols of Ovarian Stimulation on Oocyte Quality
Interventions: DRUG: Cetrorelix and Leuprolide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Study to Evaluate Safety and Tolerability of a Recombinant Herpes Zoster Vaccine
Status: RECRUITING
Conditions: Herpes Zoster|Vaccine-Preventable Diseases
Interventions: BIOLOGICAL: Low Dose Recombinant Herpes Zoster Vaccine (LZ901)|BIOLOGICAL: High Dose Recombinant Herpes Zoster Vaccine (LZ901)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of an Alternative Method of Obtaining Viral RNA for the Detection of SARS-CoV-2 Virus Using PCR
Status: UNKNOWN
Conditions: COVID|SARS-CoV2|Corona Virus Infection
Interventions: DIAGNOSTIC_TEST: Obtainment of nasopharyngeal, oropharyngeal, buccal, nasal and saliva samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p