pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Use of Sorafenib and/or Regorafenib in Liver Cancer (Hepatocellular Carcinoma) Subsequent to Another Systemic First-line Treatment
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Regorafenib (Stivarga, BAY73-4506)|DRUG: Sorafenib (Nexavar, BAY43-9006)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Postoperative Analgesic Effectiveness of Superficial and Deep Serratus Plane Blocks for Mastectomy
Status: NOT_YET_RECRUITING
Conditions: Mastectomy|Postoperative Pain|Analgesia
Interventions: PROCEDURE: superficial or deep serratus anterior plane block for mastectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Acalabrutinib and Rituximab for the Treatment of Previously Untreated Mantle Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Acalabrutinib|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-marketing Clinical Trial of Elexir(Trigeminal Nerve Electrical Stimulator) for the Acute Treatment of Migraine
Status: RECRUITING
Conditions: Migraine
Interventions: DEVICE: Elexir (program1)|DEVICE: sham device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ischemic Conditioning to Enhance Function (I-C-FUN) in Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: BEHAVIORAL: RLIC|BEHAVIORAL: Sham Conditioning|BEHAVIORAL: Muscle Power training|BEHAVIORAL: Balance training|BEHAVIORAL: Treadmill Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Cyclosporine vs. Placebo for Epiphora Associated With Docetaxel
Status: WITHDRAWN
Conditions: Epiphora
Interventions: DRUG: Cyclosporine Eye Drops (Restasis)|DRUG: Lubricant Eye Drops (Refresh Endura™)|DRUG: Fluorometholone Eye Drops (FML Forte®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Artificial Balneotherapy, Phototherapy and Artificial Balneophototherapy in the Treatment of Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: RADIATION: phototherapy|PROCEDURE: balneotherapy|PROCEDURE: balneophototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The MATCH (Medication Aids for Tobacco Cessation and Health) Study
Status: COMPLETED
Conditions: Tobacco Use Disorder|Nicotine Dependence
Interventions: DRUG: Bupropion|DRUG: Varenicline|BEHAVIORAL: Weekly Motivational Emails
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Capravirine Plus VIRACEPT Plus Two Nucleoside Reverse Transcriptase Inhibitors in HIV-Infected Patients Who Failed Previous Anti-HIV Treatments
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Capravirine|DRUG: Nelfinavir mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of a Lateral Wedge Insole and Simple Knee Sleeve in Individuals With Knee Osteoarthritis
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Lateral wedge insole (insole)|DEVICE: simple knee sleeve (sleeve)|DEVICE: simple knee sleeve + lateral wedge insole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Levomilnacipran in Healthy Males
Status: UNKNOWN
Conditions: None (i.e. Healthy Volunteers)
Interventions: DRUG: Levomilnacipran|DRUG: Duloxetine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparator-Controlled Study for EGFR(+) Patients With Multiple BMs From NSCLC (BROKE) (EGFR-epidermal Growth Factor Receptor;BM-brain Metastases)
Status: UNKNOWN
Conditions: Non-Small Cell Lung Cancer|Brain Metastases|EGFR Gene Mutation
Interventions: DRUG: Gefitinib|RADIATION: WBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extension Study of Lirentelimab in Eosinophilic Gastritis and/or Eosinophilic Duodenitis (Formerly Referred to as Eosinophilic Gastroenteritis)
Status: COMPLETED
Conditions: Eosinophilic Gastritis|Eosinophilic Duodenitis
Interventions: DRUG: lirentelimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Neuromuscular Exercise Training on Core Stability and Hip Strength in Healthy Adolescent Females
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Injury
Interventions: OTHER: Neuromuscular exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pneumococcal Conjugate Vaccine With Pneumococcal Polysaccharide Vaccine and Tetanus/Diphtheria Vaccine
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: Tetanus-diphtheria toxoids (Td)|BIOLOGICAL: 7-valent pneumococcal conjugate vaccine|BIOLOGICAL: 23-valent polysaccharide vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Surgical Stabilization of Rib Fractures While Awake or Under Appropriate Sedation by Paravertebral Block
Status: COMPLETED
Conditions: Rib Fracture Multiple|Anesthesia, Local
Interventions: PROCEDURE: internal fixation of mulitiple rib fracture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local DHEA and Estradiol on Dyspareunia in Postmenopausal Women
Status: RECRUITING
Conditions: Vulvovaginal Atrophy|Genitourinary Syndrome of Menopause
Interventions: DRUG: vaginal estradiol 10 μg|DRUG: vaginal DHEA 6.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Gastrointestinal Bleeding in Patients With Severe Ischemic Heart Disease
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Acute Myocardial Infarction
Interventions: DRUG: esomeprazole 20 mg daily|DRUG: famotidine 40 mg daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant of Sintilimab Combined With Chemotherapy for Resectable NSCLC（neoSCORE）
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: sintilimab|DRUG: pemetrexed|DRUG: Carboplatin|DRUG: albumin-bound paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Regulatory B Cells in Behçet's Disease
Status: COMPLETED
Conditions: Behcet Disease
Interventions: DIAGNOSTIC_TEST: Flow-cytometric assay|DIAGNOSTIC_TEST: 2D Echocardiographic analysis|DIAGNOSTIC_TEST: Two-Dimensional speckle tracking echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pediatric Safety and Immunogenicity Study of Cell-Culture Derived and Egg-based Subunit Influenza Vaccines in Healthy Children and Adolescents
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Cell culture-derived influenza subunit vaccine (cTIV)|BIOLOGICAL: Egg derived influenza subunit vaccine (eTIV)|BIOLOGICAL: Cell culture-derived influenza subunit vaccine (cTIV)|BIOLOGICAL: Egg derived influenza subunit vaccine (eTIV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of an Endoscopic Sutured Gastroplasty in Patients With NonAlcoholic Steatohepatitis (NASH) and Fibrosis.
Status: UNKNOWN
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: DEVICE: Endomina®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects With Hepatic Impairment
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2|Healthy
Interventions: DRUG: semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Nocturnal Hemodialysis (NHD) and Short Daily Hemodialysis (DHD) With the NxStage® System One™
Status: COMPLETED
Conditions: Kidney Failure, Chronic|End-Stage Renal Disease
Interventions: DEVICE: NxStage System One
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SB-715992 in Treating Patients With Advanced or Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Recurrent Colon Cancer|Recurrent Rectal Cancer|Stage IIIA Colon Cancer|Stage IIIA Rectal Cancer|Stage IIIB Colon Cancer|Stage IIIB Rectal Cancer|Stage IIIC Colon Cancer|Stage IIIC Rectal Cancer|Stage IVA Colon Cancer|Stage IVA Rectal Cancer|Stage IVB Colon Cancer|Stage IVB Rectal Cancer
Interventions: DRUG: ispinesib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation With Double Cone Coil in Chronic Tinnitus
Status: COMPLETED
Conditions: Chronic Tinnitus
Interventions: DEVICE: Medial Frontal rTMS Double-Cone-Coil|DEVICE: Left DLPFC Butterfly Coil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CRT( Chemo-Radiation Therapy) Patterns and Short-term Outcomes on Unresectable NSCLC in Routine Practices in Russia
Status: RECRUITING
Conditions: Unresectable /Inoperable Locally Advanced (Stage II-III) Non-small Cells Lung Cancer (NSCLC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Investigate the Efficacy and Safety of UB-421 Monotherapy in HIV-1 Infected Adults
Status: WITHDRAWN
Conditions: HIV-1 Infection
Interventions: DRUG: UB-421|DRUG: current standard HAART treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Meditation On Quality Of Life In Women With Breast Cancer And Other Gynecological Cancers
Status: COMPLETED
Conditions: Breast Cancers|Gynecologic Cancer
Interventions: BEHAVIORAL: Mindfulness based meditation program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase I Study of Disulfiram and Copper Gluconate for the Treatment of Refractory Solid Tumors Involving the Liver
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Disulfiram|DRUG: Copper Gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home-based Digital Exercise Training Program to Improve Physical Function of Older Sepsis Survivors - HEAL Sepsis Trial
Status: RECRUITING
Conditions: Exercise Program|Standard Care Control
Interventions: OTHER: App-based exercise program|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Pharmacokinetics and Safety of Olaparib Alone and With Paclitaxel in Chinese Patients With Advanced Solid Tumour.
Status: COMPLETED
Conditions: Advanced Solid Tumours
Interventions: DRUG: Olaparib|DRUG: Paclitaxel|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pemvidutide in Subjects With Nonalcoholic Steatohepatitis (NASH) (IMPACT Trial)
Status: RECRUITING
Conditions: Non-Alcoholic Steatohepatitis (NASH)
Interventions: DRUG: Pemvidutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coenzyme Q10 and Chemotherapeutic Toxicity in Breast Cancer Patients
Status: RECRUITING
Conditions: Breast Cancer|Chemotherapeutic Toxicity
Interventions: DRUG: Placebo|DRUG: Coenzyme Q10 200mg twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Intravenous Ferritin in Optimizing Postoperative Recovery Following Pancreaticoduodenectomy
Status: NOT_YET_RECRUITING
Conditions: Pancreaticojuodenectomy
Interventions: DRUG: The intravenous ferritin group|DRUG: The placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Chemotherapy With or Without Intercalated Icotinib
Status: NOT_YET_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Icotinib|DRUG: Placebo|OTHER: chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Follow-up After Laparoscopic Inguinal Hernia Repair Using Tisseel for Mesh Fixation
Status: COMPLETED
Conditions: Hernia, Inguinal|Recurrence|Chronic Pain
Interventions: PROCEDURE: Fibrin Sealant|PROCEDURE: Tissue-penetrating mesh-fixation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Accelerometers' Validity in Counting Number of Steps in the Elderly Subjects Before Discharge From Rehabilitation Units
Status: COMPLETED
Conditions: Geriatrics
Interventions: DEVICE: Accelerometers positioned at the wrinkle, the hip, and the ankle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Prucalopride in Patients With Severe Chronic Idiopathic Constipation
Status: COMPLETED
Conditions: Chronic Constipation
Interventions: DRUG: prucalopride|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: P2Y12 Inhibitor-based Single Antiplatelet Therapy After a Short DAPT vs. Conventional DAPT Following PCI With a Polymer-free Drug-coated Stent for Unprotected Left Main Coronary Artery Disease (ULTRA-LM)
Status: NOT_YET_RECRUITING
Conditions: Left Main Coronary Artery Stenosis
Interventions: DEVICE: LMCA PCI with Biofreedom Ultra drug-coated stent (Biosensors International, Switzerland)|DRUG: P2Y12 inhibitor-based SAPT after short DAPT|DRUG: Conventional DAPT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lidocaine In-situ Gel Prior to Intrauterine Device Insertion in Women With no Previous Vaginal Delivery
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: lidocaine gel|DRUG: placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Choose Health: Food, Fun, and Fitness Curriculum Promotes Positive Behaviors in 3rd-5th Graders Compared to Control
Status: COMPLETED
Conditions: Childhood Obesity|Nutrition Poor
Interventions: BEHAVIORAL: CHFFF nutrition education
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pain Control Using Neuromodulation in Patients Undergoing Definitive Chemoradiotherapy for Head and Neck Cancer
Status: COMPLETED
Conditions: Cancer of Head and Neck
Interventions: DEVICE: Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase II, Dose Ranging Study Of CP-690,550 Eye Drops In Patients With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: CP-690,550 Eye drops|DRUG: CP-690,550 Eye drops|DRUG: CP-690,550 Eye drops|DRUG: CP-690,550 Eye drops-vehicle|DRUG: Sodium Hyaluronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Etomidate vs. Midazolam for Sedation During ERCP
Status: COMPLETED
Conditions: Choledocholithiasis|Cholangiocarcinoma|Pancreatitis|Pancreatic Cancer
Interventions: DRUG: Etomidate|DRUG: Midazolam|DRUG: Meperidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Etoricoxib to Treat Chronic Low Back Pain (0663-042)
Status: COMPLETED
Conditions: Recurrent Low Back Pain
Interventions: DRUG: MK0663, Etoricoxib / Duration of Treatment : 12 Weeks|DRUG: Comparator : placebo (unspecified) /Duration of Treatment : 12 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study of L.S.E.S.r. (LipidoSterolic Extract of Serenoa Repens)(PERMIXON® 160 mg Hard Capsule) Versus Tamsulosine LP Activity on Inflammation Biomarkers in Urinary Symptoms Related to BPH (Benign Prostatic Hyperplasia)
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia (BPH)
Interventions: DRUG: Permixon® 160 mg|DRUG: Tamsulosine Arrow LP|DRUG: Placebo matching Permixon® 160 mg|DRUG: Placebo matching Tamsulosine Arrow LP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of nCPAP Treatment on Liver Function in Patients With Sleep Apnea Syndrome and Nonalcoholic Steatohepatitis
Status: UNKNOWN
Conditions: Sleep Apnea Syndrome|Nonalcoholic Steatohepatitis
Interventions: DEVICE: nCPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Versatile Ampification Single-Molecule Detection in Liquid Biopsy
Status: RECRUITING
Conditions: Liquid Biopsy|Melanoma (Skin)|Melanoma Stage III|Melanoma Stage IV|BRAF V600E
Interventions: DEVICE: Affinity Mediated Transport Amplification (AMT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Mindfulness-Based Breastfeeding Programme in Mothers After Cesarean Delivery
Status: NOT_YET_RECRUITING
Conditions: Breastfeeding
Interventions: BEHAVIORAL: Mindfulness-Based Breastfeeding Programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vancomycin vs. Vancomycin Plus Gentamycin in Treatment of MRSA Infection
Status: COMPLETED
Conditions: Staphylococcus Aureus
Interventions: DRUG: Vancomycin|DRUG: Vancomycin plus Gentamicin|DRUG: Vancomycin plus Rifampin|DRUG: Vancomycin plus Gentamicin plus Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose:
Clinical trial: Phase II Pilot Study of Vincristine, Adriamycin, Actinomycin D, Ifosfamide Combination Chemotherapy in Ewing's Sarcoma
Status: UNKNOWN
Conditions: Ewing's Sarcoma
Interventions: DRUG: Vincristine, Actinomycin-D, Ifosfamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Choice of Diction's Effect
Status: UNKNOWN
Conditions: Communication|Advance Directives|Decision Making|Cardiopulmonary Resuscitation
Interventions: OTHER: Alternative phrasing for no code|OTHER: Standard of care for no code
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Neuromuscular Electrical Stimulation Applied to the Lumbar Multifidus Muscle on Sit to Stand Kinematics in Individuals With Low Back Pain
Status: NOT_YET_RECRUITING
Conditions: Low Back Pain
Interventions: OTHER: Superimposed Neuromuscular Electrical Stimulation|OTHER: Conventional Neuromuscular Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicomponent Risk Factor Intervention for People With a Severe Mental Illness: a Feasibility Study
Status: COMPLETED
Conditions: Psychotic Disorder|Obesity|Behavior, Addictive
Interventions: DRUG: nicotine transdermal patch/lozenge
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Swedish Massage Prior Circuit Breathing Training on Asthma
Status: ACTIVE_NOT_RECRUITING
Conditions: Asthma; Status
Interventions: OTHER: Control|OTHER: Swedish massage prior circuit breathing training group (SBT)|OTHER: Circuit breathing training group (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Chronic Itch in Patients Under Arsenic Exposure With Sublingual Naloxone
Status: COMPLETED
Conditions: Chronic Pruritus
Interventions: DRUG: Naloxone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Whole Body Vibration on Neck Disability and Proprioception in Patients With Forward Head Posture
Status: COMPLETED
Conditions: Forward Head Posture
Interventions: OTHER: Whole body vibration training|OTHER: Conventional physical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effectiveness of NuvaRing® to Prevent Pregnancies in Chinese Women (P06450)
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: ENG 120 µg + EE 15 µg intravaginal ring|DRUG: DRSP 3 mg + EE 30 µg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 2 College Truths and 1 Lie
Status: ENROLLING_BY_INVITATION
Conditions: Underage Drinking
Interventions: BEHAVIORAL: Gamified Social Norms Marketing Campaign|BEHAVIORAL: Social Norms Marketing Campaign
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of L-methylfolate and Methylcobalamine in Treating Hypertension and Its Impact on Serum Homocysteine in Hemodialysis Patients With Resistant Hypertension
Status: ACTIVE_NOT_RECRUITING
Conditions: End Stage Renal Disease|Hypertension, Renal
Interventions: DRUG: L-Methyl Folate and methylcobalamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The eSVS® Mesh Post-Marketing Trial
Status: TERMINATED
Conditions: Coronary Artery Disease|Myocardial Ischemia|Coronary Disease|Heart Diseases|Cardiovascular Diseases|Arteriosclerosis|Arterial Occlusive Diseases|Vascular Diseases
Interventions: DEVICE: eSVS Mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blended Collaborative Care for Heart Failure and Co-Morbid Depression
Status: COMPLETED
Conditions: Heart Failure, Systolic|Depression|Cardiovascular Disease
Interventions: BEHAVIORAL: Collaborative Care for Heart Failure|BEHAVIORAL: Collaborative Care for Depression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Ivermectin for the Prevention of Covid-19 Infection in Colombian Health Personnel
Status: UNKNOWN
Conditions: Covid19|Healthcare Worker Patient Transmission
Interventions: DRUG: Ivermectin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Study of a Vaccine to Help Protect Against Lyme Disease in Healthy Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Lyme Disease
Interventions: BIOLOGICAL: VLA15|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Breathing Training on Psychosocial Functioning and Heart Rate Variability in Postmenopausal Women With Depressive Symptoms-3
Status: WITHDRAWN
Conditions: Postmenopause
Interventions: BEHAVIORAL: Breathing training|BEHAVIORAL: Stress management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cranial Electrotherapy Stimulation (CES) for Soldiers With Combat-Related Symptoms
Status: UNKNOWN
Conditions: Combat Related Symptoms|Irritability|Anger
Interventions: PROCEDURE: cranial electrotherapy stimulation (CES) with Alpha-Stim|PROCEDURE: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of Ciclesonide in the Treatment of Non-hospitalized COVID-19 Patients
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Ciclesonide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomised, Placebo-controlled Safety and Pharmacokinetics Study of Novel Rifaximin Formulations in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Rifaximin Novel Formulation|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neo-adjuvant Therapy With Anastrozole Plus Pazopanib in Stage II and III ER+ Breast Cancer
Status: TERMINATED
Conditions: Estrogen Receptor-positive Breast Cancer|Human Epidermal Growth Factor 2 Negative Carcinoma of Breast|Male Breast Cancer|Recurrent Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer
Interventions: DRUG: anastrozole|DRUG: pazopanib hydrochloride|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplementation With Human Chorionic Gonadotropin (hCG) During Controlled Ovarian Stimulation With Recombinant Follicle-stimulating Hormone (FSH) for In Vitro Fertilisation
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: rFSH|DRUG: human chorionic gonadotropin|DRUG: human chorionic gonadotropin|DRUG: human chorionic gonadotropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reciprocation vs Rotational Single-file Systems in Postoperative Pain
Status: COMPLETED
Conditions: Apical Periodontitis|Assessment, Pain|Dental Pulp Necrosis
Interventions: PROCEDURE: Reciprocating single-file system|PROCEDURE: Rotational single-file system.|PROCEDURE: Active comparator Protaper multi-file system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-Intensity Laser Therapy Versus Shockwave Therapy in Osteoporotic Long Term Hemiparetic Patients
Status: COMPLETED
Conditions: Osteoporosis Secondary
Interventions: RADIATION: High-Intensity laser|OTHER: Traditional physiotherapy exercises|RADIATION: Shock Wave therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Equine Assisted Therapy in Autism Spectrum Disorder
Status: COMPLETED
Conditions: Equine-Assisted Therapy|Autism Spectrum Disorder
Interventions: OTHER: Hippotherapy|OTHER: Equine-Assisted Activities Therapy|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mildronate for Acute Ischemic Stroke
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DRUG: mildronate injection|DRUG: cinepazide maleate injection|DRUG: aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alsertib (MLN8237) and Brentuximab Vedotin for Relapsed/Refractory CD30-Positive Lymphomas and Solid Malignancies
Status: WITHDRAWN
Conditions: CD30-positive Lymphoma|CD30-positive Solid Tumor
Interventions: DRUG: Brentuximab Vedotin|DRUG: Alsertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Augmenting Cognitive Training In Older Adults
Status: COMPLETED
Conditions: Aging
Interventions: BEHAVIORAL: Cognitive Training|DEVICE: tDCS (active stimulation)|DEVICE: tDCS (sham stimulation)|BEHAVIORAL: Educational Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gait Examination in Patients With Hemophilia in Austria
Status: COMPLETED
Conditions: Hemophilia
Interventions: DIAGNOSTIC_TEST: 3-d gait examination (level walking)|DIAGNOSTIC_TEST: Anthropometrics and body composition assessment|DIAGNOSTIC_TEST: Biomarkers|DIAGNOSTIC_TEST: Clinical examination|DIAGNOSTIC_TEST: Habitual physical activity tracking (accelerometer based)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of PTC923 (CNSA-001) in Primary Tetrahydrobiopterin (BH4) Deficient Participants With Hyperphenylalaninemia
Status: COMPLETED
Conditions: BH4 Deficiency|Hyperphenylalaninemia
Interventions: DRUG: PTC923
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Piracetam on Aphasia After Acute Ischemic Cerebral Artery Stroke
Status: TERMINATED
Conditions: Acute Ischaemic Middle Cerebral Artery Stroke
Interventions: DRUG: Piracetam|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I, Pharmacological, and Biological Study of OSI-774 in Combination With FOLFOX 4 (5-FU, Leucovorin, and Oxaliplatin) and Bevacizumab (Avastin) in Patients With Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Mucinous Adenocarcinoma of the Colon|Mucinous Adenocarcinoma of the Rectum|Recurrent Colon Cancer|Recurrent Rectal Cancer|Signet Ring Adenocarcinoma of the Colon|Signet Ring Adenocarcinoma of the Rectum|Stage IIIA Colon Cancer|Stage IIIA Rectal Cancer|Stage IIIB Colon Cancer|Stage IIIB Rectal Cancer|Stage IIIC Colon Cancer|Stage IIIC Rectal Cancer|Stage IVA Colon Cancer|Stage IVA Rectal Cancer|Stage IVB Colon Cancer|Stage IVB Rectal Cancer
Interventions: DRUG: erlotinib hydrochloride|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin|BIOLOGICAL: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of a Resorbable PLLA Implant for Regeneration of the Anterior Cruciate Ligament (ACL)
Status: COMPLETED
Conditions: Complete Tear, Knee, Anterior Cruciate Ligament
Interventions: DEVICE: L-C Ligament
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictive Biomarkers for Pneumonitis After Chemoradiotherapy and Immunotherapy in Patients With Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Lung Non-Small Cell Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bronchoscopy with Bronchoalveolar Lavage|OTHER: Chemoradiotherapy|PROCEDURE: Computed Tomography|OTHER: Diagnostic Laboratory Biomarker Analysis|DRUG: Immune Checkpoint Inhibitor|PROCEDURE: Nasal Wash and Collection|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Spirometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 4 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary Cholangitis
Status: TERMINATED
Conditions: Liver Cirrhosis, Biliary
Interventions: DRUG: Obeticholic Acid (OCA)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment and Thickness Changes of the Oblique and Multifidus Muscles
Status: COMPLETED
Conditions: Abdominal Muscles
Interventions: OTHER: Rotation Exercises|OTHER: Control Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Efficacy and Safety of Delgocitinib Cream in Adults With Moderate to Severe Chronic Hand Eczema
Status: COMPLETED
Conditions: Chronic Hand Eczema
Interventions: DRUG: Delgocitinib cream|DRUG: Cream vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prediction and Validation of Unipolar Depression With Psychosocial-somatic Markers in a Naturalistic Cohort Recruited in an Outpatient Setting
Status: NOT_YET_RECRUITING
Conditions: Depressive Disorder|Depression|Depressive Symptoms|Depressive Episode|Major Depressive Disorder
Interventions: DIAGNOSTIC_TEST: drawing blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Phase IIb Study of STA-2 in Patients With Chronic Stable Angina
Status: COMPLETED
Conditions: Chronic Stable Angina
Interventions: DRUG: green tea polyphenols (STA-2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center
Status: NOT_YET_RECRUITING
Conditions: Traumatic Injury|PTSD|Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Treatment as Usual|BEHAVIORAL: Brief Prolonged Exposure Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EXecutive RCT: Evaluating XIENCE V® in a Multi Vessel Disease
Status: COMPLETED
Conditions: Coronary Disease|Coronary Artery Disease|Coronary Artery Stenosis|Coronary Artery Restenosis
Interventions: DEVICE: XIENCE V® Everolimus Eluting Coronary Stent System|DEVICE: TAXUS® Liberté™ Paclitaxel Eluting Coronary Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of PENS of the Auricle as an Opioid Sparing Postoperative Analgesic Technique in Cancer Endometrium and Cancer Cervix Patients
Status: RECRUITING
Conditions: Cancer of Endometrium|Cancer of Cervix
Interventions: DEVICE: Primary Relief|DEVICE: Primary Relief - Sham Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Radiation Therapy in Treating Patients With Cancer of the Esophagus
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: chemotherapy|DRUG: cisplatin|DRUG: paclitaxel|RADIATION: low-LET electron therapy|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Opioid-free Anesthesia With a Mixture of Dexmedetomidine-lidocaine-ketamine
Status: RECRUITING
Conditions: Pain, Postoperative|Pain, Acute|Pain, Chronic|Pain, Neuropathic|Pain, Nociceptive|Ketamine|Dexmedetomidine|Lidocaine|Central Nervous System Depressants|Analgesia|Analgesics|Analgesics Non-narcotic
Interventions: DRUG: ketamine-lidocaine-dexmedetomidine|DRUG: fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Health Education During Ramadan Fasting in Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Fasting
Interventions: BEHAVIORAL: IDF modules|BEHAVIORAL: Conversational Maps
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Role of the Intestinal Microbiome in Enteric and Systemic Vaccine Immune Responses
Status: COMPLETED
Conditions: Rotavirus Infections|Intestinal Bacteria Flora Disturbance|Reaction - Vaccine Nos|Tetanus|Streptococcal Pneumonia
Interventions: BIOLOGICAL: Rotavirus vaccine, Tetanus vaccine and Pneumococcal vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Investigating the Effect of Nasal High Flow Oxygen Therapy on Regional Lung Function
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Nasal High Flow|Dynamic Volumetric Computed Tomography
Interventions: RADIATION: Computed tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inpatient Attending Physician Rotation Duration Study
Status: COMPLETED
Conditions: Inpatient Attending Physician Staffing Model
Interventions: OTHER: 2-week rotation|OTHER: 4-week rotation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell Transplantation
Status: COMPLETED
Conditions: Breast Cancer|Chronic Myeloproliferative Disorders|Gestational Trophoblastic Tumor|Infection|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Neuroblastoma|Ovarian Cancer|Testicular Germ Cell Tumor
Interventions: DRUG: ravuconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Safety, Pharmacokinetics and Pharmacodynamics of EXPAREL® Administered Via a Single Intrathecal Injection to Healthy Volunteers
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: EXPAREL|DRUG: Bupivacaine Hydrochloride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Timely Intravenous Magnesium for Asthma in Children
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Magnesium Sulfate, Heptahydrate|DRUG: 0.9% saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetics and Safety Study of Nemolizumab in Adolescent Participants With Atopic Dermatitis (AD)
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: Nemolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn's Disease
Interventions: DRUG: Guselkumab Dose 1|DRUG: Guselkumab Dose 2|DRUG: Guselkumab Dose 3|DRUG: Guselkumab Dose 4|DRUG: Guselkumab Dose 5|DRUG: Guselkumab|DRUG: Ustekinumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety andTolerability Study of Multiple Doses of ISIS-DMPKRx in Adults With Myotonic Dystrophy Type 1
Status: COMPLETED
Conditions: Myotonic Dystrophy Type 1
Interventions: DRUG: IONIS-DMPKRx|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ablation vs Amiodarone for Treatment of AFib in Patients With CHF and an ICD
Status: COMPLETED
Conditions: Heart Failure
Interventions: PROCEDURE: Atrial Fibrillation ablation|DRUG: Amiodarone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Vasopressor Boluses for Management of Hypotension After Spinal Anesthesia
Status: UNKNOWN
Conditions: Cesarean Section Complications|Spinal Anesthetic Toxicity
Interventions: DRUG: Norepinephrine 6 mcg|DRUG: Norepinephrine 10 mcg|DRUG: Bupivacaine Hydrochloride|DRUG: Norepinephrine infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Abraxane Plus Ipilimumab in Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: ABI-007|DRUG: Ipilimumab|BEHAVIORAL: Phone Call
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Auricular Acupuncture Stimulation for Chronic Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Low Back Pain
Interventions: OTHER: Stimulation at Location 1|OTHER: Stimulation at Location 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Treatments Following Total Knee Replacement
Status: COMPLETED
Conditions: Degeneration; Articular Cartilage, Knee|Rheumatoid Arthritis|Osteoarthritis, Knee
Interventions: OTHER: Clinic-based outpatient exercise group|OTHER: Community-based exercise group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Standard vs. Modified Reconsolidation Blockade for the Treatment of Psychological Trauma
Status: NOT_YET_RECRUITING
Conditions: Trauma and Stressor Related Disorders|Post Traumatic Stress Disorder|Acute Stress Disorder|Adjustment Disorders
Interventions: DRUG: Propranolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Breast Cancer With Intraoperative Radiotherapy Followed by Hypofractionated External Beam Radiotherapy
Status: RECRUITING
Conditions: Breast Cancer
Interventions: RADIATION: Intraoperative Radiotherapy (IORT)|PROCEDURE: Breast conservative surgery|RADIATION: External Beam Hypofractionated Radiotherapy (EBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Rising Oral Doses and Multiple Rising Oral Doses of BI 1356 BS in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1356 BS - single rising dose|DRUG: BI 1356 BS - multiple rising dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Clinical Study of Forodesine in Japanese Recurrent/Refractory Peripheral T-cell Lymphoma Patients
Status: COMPLETED
Conditions: Recurrent or Refractory PTCL
Interventions: DRUG: forodesine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An mHealth Strategy to Improve Medication Adherence in Adolescents With Sickle Cell Disease
Status: RECRUITING
Conditions: Sickle Cell Disease|Sickle Beta Zero Thalassemia|Sickle B+ Thalassemia|Sickle Cell Hemoglobin C
Interventions: BEHAVIORAL: MED-Go App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Miracle Fruit Pill Application on Food Likings and Energy Intake in Diabetic or Prediabetic Patients
Status: COMPLETED
Conditions: Diabetes|PreDiabetes
Interventions: OTHER: Oral application of miracle fruit pill|OTHER: Oral application of sugar candy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE