pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Neoadjuvant Therapy of SBRT Sequencial With Toripalimab and Chemotherapy in Resectable Stage II-III NSCLC Patients(neoR-TORCH)
Status: NOT_YET_RECRUITING
Conditions: Stage II-III Non-small Cell Lung Cancer
Interventions: RADIATION: SBRT|DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apparent Life Threatening Events, Sudden Infant Death Syndrome and Muscarinic Receptors
Status: UNKNOWN
Conditions: Apparent Life-Threatening Event in Infants Under One Year of Age
Interventions: BIOLOGICAL: Blood sample for specific analyzes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Characterization and Elimination of Mother Rotors
Status: WITHDRAWN
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: standard circumferential pulmonary vein isolation by radiofrequency ablation catheter|PROCEDURE: CPVI + rotors' identification and ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Piloting the IPROACTIF Program to Preserve Functioning and Prevent Cognitive Decline
Status: COMPLETED
Conditions: Heart Disease (Coronary Artery Disease, Ischemic Heart Disease, Hypertensive Heart Disease)|Uncontrolled Diabetes (HBA1c ≥ 10)
Interventions: OTHER: IPROACTIF (Integrated PRimary Care and Occupational Therapy for Aging and Chronic Disease Treatment to preserve Independence and Functioning)|OTHER: Usual primary care services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Deep Neuromuscular Block for Laparoscopic Surgery
Status: COMPLETED
Conditions: Laparoscopy|Anesthesia Recovery Period
Interventions: DRUG: Sugammadex|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity
Status: RECRUITING
Conditions: Lymphoproliferative Disorders|Autoimmune Lymphoproliferative|Immune System Diseases|Common Variable Immunodeficiency|Primary T-cell Immunodeficiency Disorders
Interventions: DRUG: Busulfan test dose|DRUG: Fludarabine|DRUG: Busulfan|DRUG: Alemtuzumab|RADIATION: Total body Irradiation|PROCEDURE: Allogeneic HSCT|DRUG: Tacrolimus (Tacro)|DRUG: Mycophenolate mofetil (MMF)|DRUG: Cyclophosphamide (Cytoxan)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Leak-Free Bronchoscope Adapter to Limit Ventilated Air Volume Loss During Bronchoscopy
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Disease
Interventions: DEVICE: Leak-free bronchoscope adapter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neratinib +/- Fulvestrant in Metastatic HER2 Non-amplified But HER2 Mutant Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Neratinib|DRUG: Fulvestrant|DRUG: Trastuzumab|PROCEDURE: Tumor biopsy|PROCEDURE: Research blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Praziquantel in Children Under Age 4
Status: UNKNOWN
Conditions: Schistosomiasis|Schistosomiasis Mansoni|Schistosoma Japonicum Infection
Interventions: DRUG: Praziquantel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma
Status: RECRUITING
Conditions: Glioma, Malignant
Interventions: DRUG: D2C7-IT|DRUG: 2141-V11
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LC542019 in Healthy Subjects and Subjects With T2DM
Status: COMPLETED
Conditions: Healthy|Diabetes Mellitus, Type 2
Interventions: DRUG: LC542019|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Efficacy of Pristinamycin (Pyostacine ®) Versus Amoxicillin in the Treatment of Acute Community Acquired Pneumonia
Status: TERMINATED
Conditions: Pneumonia
Interventions: DRUG: PRISTINAMYCIN XRP7263|DRUG: Amoxicillin|DRUG: Amoxicillin Placebo|DRUG: PRISTINAMYCIN Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial for Optimal Novel Oral Anticoagulant (NOAC) Schedule Immediate Before Catheter Ablation for Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DRUG: novel oral anticoagulant for 30 days|DRUG: novel oral anticoagulant for 24 hour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Administration of Autologous CAR-T CD19 Antigen With Inducible Safety Switch in Patients With Relapsed/Refractory ALL
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Immune System Diseases|Immunoproliferative Disorders
Interventions: BIOLOGICAL: iC9-CAR19 cells|DRUG: Rimiducid|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polidocanol Foam VS Artery Ligation in Hemorrhoidal Disease
Status: COMPLETED
Conditions: Hemorrhoids
Interventions: DRUG: Polidocanol foam sclerotherapy|PROCEDURE: Doppler-guided hemorrhoidal artery ligation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of a Peanut Immunotherapy Dissolving Film for Peanut Allergy
Status: TERMINATED
Conditions: Peanut Allergy
Interventions: DRUG: Peanut Dissolving Film
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intraoperative Ketamine on Opioid Consumption and Pain After Spine Surgery in Opioid-dependent Patients
Status: COMPLETED
Conditions: Postoperative Pain|Chronic Pain|Analgesics
Interventions: DRUG: (S)-(+)-Ketamine Hydrochloride Solution 25 mg/ml|DRUG: Isotonic sodium chloride 0.9 percent|DRUG: Paracetamol 1 g|DRUG: Morphine Sulphate 1 mg/ml|DRUG: Morphine Sulphate 1 mg/ml|DRUG: Ondansetron 2 mg/ml|DRUG: Usual daily opioids|DRUG: Morphine Sulphate 1 mg/ml|DRUG: Sufentanil 5 microgram/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tributyrin in Treating Patients With Refractory Prostate Cancer or Other Solid Tumors
Status: COMPLETED
Conditions: Prostate Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: chemotherapy|DRUG: tributyrin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence and Efficacy Study of MB-102 (Relmapirazin) in Chinese Participants
Status: COMPLETED
Conditions: Kidney Diseases|Kidney Injury|Kidney Failure
Interventions: DRUG: MB-102 DMID|DRUG: MB-102 OMID|DEVICE: MediBeacon Transdermal Glomerular Filtration Rate Measurement System (TGFR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Daily Coping Toolkit for Medical Personnel and First-Responders During COVID-19 Pandemic
Status: UNKNOWN
Conditions: Psychological Stress
Interventions: BEHAVIORAL: Daily Coping Toolkit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Subcutaneous Doses of CM-101 as a Treatment for Medical Conditions Involving Inflammatory and Fibrotic Mechanisms in Healthy Male Subjects
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis (NASH)|Primary Sclerosing Cholangitis (PSC)|Systemic Sclerosis (SSc)
Interventions: DRUG: CM-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Lidocaine Anesthesia for Nasopharyngeal Sampling
Status: COMPLETED
Conditions: Nasopharyngeal Sampling|Local Anesthesia
Interventions: DRUG: Lidocaine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Strengthening of the First Dorsal Interosseous for Thumb Carpometacarpal Osteoarthritis
Status: RECRUITING
Conditions: Thumb Osteoarthritis|First Dorsal Interosseous Strengthening
Interventions: DEVICE: Splint|DEVICE: Splint with strengthening exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Furmonertinib Monotherapy and Combination Therapy in Advanced EGFR Mutant NSCLC With Uncleared ctDNA
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Furmonertinib|DRUG: Furmonertinib|DRUG: Furmonertinib/Pemetrexed/Carboplatin|DRUG: Furmonertinib/Pemetrexed/Carboplatin/Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epirubicin Versus Docetaxel Plus Cyclophosphamide in Lymph Node Negative, ER-positive, Her2-negative Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Epirubicin|DRUG: Docetaxel|DRUG: cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Egg Consumption and Its Enrichment With Annatto on Cardiovascular Risk and Satiety in Healthy Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Whole egg|DIETARY_SUPPLEMENT: Annatto-enriched egg|DIETARY_SUPPLEMENT: Egg whites - Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety Study of Nivolumab With Nab-Paclitaxel Plus or Minus Gemcitabine in Pancreatic Cancer, Nab-Paclitaxel / Carboplatin in Stage IIIB/IV Non-Small Cell Lung Cancer or Nab-Paclitaxel in Recurrent Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms|Pancreatic Neoplasms
Interventions: DRUG: nab-Paclitaxel|DRUG: Nivolumab|DRUG: Gemcitabine|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REcommened Communication With Sympathy in Terminally Ill Cancer Patients Treated With Palliative Sedation
Status: UNKNOWN
Conditions: Communication, Palliative Sedation
Interventions: OTHER: healthcare provider's recommended communication with sympathy and printed paper
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effectiveness of Two Therapies to Treat Signs of Anorexia Nervosa in Adolescents
Status: COMPLETED
Conditions: Eating Disorders
Interventions: BEHAVIORAL: Family-Based Therapy ("Maudsley Method")|BEHAVIORAL: Individual Supportive Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of 30% Metformin and 2% Nicotinamide Lotion With Kligman Formula in the Treatment of Melasma
Status: COMPLETED
Conditions: Melasma
Interventions: DRUG: Metformin and Nicotinamide vs Kligman Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Hand Assisted Versus "Pure" Laparoscopic Assisted Proctectomy for Rectal Cancer
Status: WITHDRAWN
Conditions: Rectal Cancer
Interventions: PROCEDURE: HAL proctectomy|PROCEDURE: "straight" laparoscopic proctectomy|PROCEDURE: Hand-assisted laparoscopic proctectomy|PROCEDURE: SL Proctectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Assessing the Effect of Cyclin-dependent Kinase 4/6 Inhibitors on Body Composition in Patients With ER+/HER2- Metastatic Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DIAGNOSTIC_TEST: CT scans|DIAGNOSTIC_TEST: DEXA scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the DPP-4 Inhibitor Sitagliptin in the Treatment of Non-Alcoholic Fatty Liver Disease Using MRI
Status: WITHDRAWN
Conditions: Type 2 Diabetes|Non-alcoholic Fatty Liver Disease
Interventions: DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn How Different Amounts of the Study Medicine Called PF-06954522 Are Tolerated and Act in the Body in Healthy Adults
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: PF-06954522|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nutritional Treatment of Overweight Adolescents With Cardiovascular Risk Factors (PowerUp)
Status: TERMINATED
Conditions: Childhood Obesity|Dyslipidemia|Insulin Resistance|Hypertension
Interventions: OTHER: Diet|OTHER: Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double Blind, Crossover Study of Fish Oil [EPA and DHA] for Intractable Partial Seizures
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Placebo|DRUG: High Dose Fish Oil|DRUG: Low Dose Fish Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Comparing In-laboratory Polysomnography Electrocardiogram (PSG ECG) to Simultaneously Recorded In-laboratory ECG on the CPC M1 Device
Status: COMPLETED
Conditions: Sleep Disorder
Interventions: DEVICE: CPC M1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of PRT1419 in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Sarcoma|Melanoma|Lung Cancer|Breast Cancer|Esophageal Cancer|Cervical Cancer|Head and Neck Cancer
Interventions: DRUG: PRT1419
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EDP-494-001: A Study of EDP-494 in Healthy Subjects and Hepatitis C Patients
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: EDP-494|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment Of Gastroesophageal Reflux Disease By Endoscopic Fundoplication, A Placebo-Controlled Study
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: PROCEDURE: Endoscopic gastroplication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Autologous Adipose Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury
Status: RECRUITING
Conditions: Traumatic Brain Injury
Interventions: BIOLOGICAL: Autologous HB-adMSCs|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Contribution of F-18 Fluoro-Deoxy-Glucose PET/CT (Positron Emission Tomography) to the Assessment of HCC (Hepato-cellular Carcinoma) Treatment Efficiency
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: OTHER: F18-FDG PET/CT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Ruxolitinib in Combination With PU-H71 for Treatment of Myelofibrosis
Status: TERMINATED
Conditions: Myelofibrosis|Primary Myelofibrosis|Post-polycythemia Vera Myelofibrosis|Post-essential Thrombocythemia Myelofibrosis
Interventions: DRUG: PU-H71|DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0919 Idarubicin, Cytarabine, and Pravastatin in Treating Patients With Relapsed Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: cytarabine|DRUG: idarubicin|DRUG: pravastatin sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prothrombin Times Outside the Therapeutic Range in Otherwise Stable Patients
Status: COMPLETED
Conditions: Atrial Fibrillation|Venous Thromboembolism|Ischemic Stroke|Myocardial Infarction
Interventions: DRUG: warfarin|DRUG: warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Role of Alternative Medicine in Difficult to Treat GERD Patients
Status: WITHDRAWN
Conditions: Gastroesophageal Reflux Disease
Interventions: PROCEDURE: Acupuncture|PROCEDURE: Sham Acupuncture|OTHER: Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Antioxidants, Redox Tone and Health Promotion: an Orthomolecular Study of Interactions
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Green tea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of the Brazilian Diabetes Prevention Program
Status: NOT_YET_RECRUITING
Conditions: Prediabetic State|Pre Diabetes
Interventions: BEHAVIORAL: Brazilian Diabetes Prevention Program (face-to-face care)|BEHAVIORAL: Diet|BEHAVIORAL: Brazilian Diabetes Prevention Program (remote care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treating Childhood Apraxia of Speech
Status: COMPLETED
Conditions: Childhood Apraxia of Speech
Interventions: BEHAVIORAL: Speech Motor Chaining without Biofeedback|BEHAVIORAL: Biofeedback|BEHAVIORAL: Distributed Practice|BEHAVIORAL: Massed --> Distributed Practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vorinostat and Capecitabine in Treating Patients With Metastatic or Unresectable Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: capecitabine|DRUG: vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrative Body-Mind-Spirit Intervention for Families With Children Suffering From Eczema
Status: UNKNOWN
Conditions: Eczema|Dermatitis, Atopic
Interventions: BEHAVIORAL: I-BMS for families with children suffering from eczema|BEHAVIORAL: Health education for parents whose children have eczema
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subscapularis Repair Augmentation for Total Shoulder Arthroplasty
Status: RECRUITING
Conditions: Shoulder Injuries
Interventions: DEVICE: BioBrace Augmentation|PROCEDURE: Standard Repair with Sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Responses in Tralokinumab-Treated Atopic Dermatitis - ECZTRA 5 (ECZema TRAlokinumab Trial No. 5)
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Tralokinumab|DRUG: Placebo|BIOLOGICAL: Tdap vaccine|BIOLOGICAL: Meningococcal vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PQR309 and Eribulin in Metastatic HER2 Negative and Triple-negative Breast Cancer (PIQHASSO)
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: PQR309|DRUG: Eribulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Traditional Ferguson Hemorrhoidectomy vs Stapled Hemorrhoidopexy
Status: RECRUITING
Conditions: Haemorrhoid
Interventions: PROCEDURE: Stapled hemorrhoidopexy with anoplasty|PROCEDURE: Ferguson hemorrhoidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Microalbuminuria and Allopurinol in Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes|Diabetic Nephropathy
Interventions: DRUG: Allopurinol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Ultrasound Evaluation Versus Direct Measurement of Uterine Cavity Length
Status: COMPLETED
Conditions: Dysmenorrhea|Heavy Menstrual Bleeding|Contraception
Interventions: DIAGNOSTIC_TEST: Transabdominal Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial Comparing Different Medical Devices for Infragenual Dilatation
Status: COMPLETED
Conditions: Diabetic Angiopathies|Intermittent Claudication
Interventions: PROCEDURE: Infragenual dilatation|PROCEDURE: Infragenual dilatation with stenting|PROCEDURE: Infragenual dilatation with cutting balloon|PROCEDURE: Laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monitoring Breast Cancer Immunotherapy Treatment With Advanced Positron Emission Tomography Magnetic Resonance Imaging (PET/MRI)
Status: NOT_YET_RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: [18F]FMISO-PET with contrast-enhanced MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neuroimaging the Impact of Treatment on Neural Substrates of Trust in Post-Traumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: Stress Disorders, Post Traumatic|Trust
Interventions: BEHAVIORAL: Group CPT-C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Betaine Supplementation and Lipid Metabolism in Overweight and Obese Pre-menopausal Women
Status: NOT_YET_RECRUITING
Conditions: Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: Betaine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trends in Cohabitation Status, Academic Achievement and Socio-economic Indicators After Mild Traumatic Brain Injury
Status: COMPLETED
Conditions: Mild Traumatic Brain Injury|Concussion, Mild|Academic Achievement|Specific Academic or Work Inhibition|Marriage|Marital Status|Income|Education|Socioeconomic Status|Sickness Absence
Interventions: OTHER: Mild traumatic brain injury
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Apatinib and Etoposide Capsule Versus Apatinib in Patients With Platinum Resistant Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: DRUG: Apatinib and Etoposide capsule|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Augmenting Language Therapy for Aphasia: Levodopa
Status: COMPLETED
Conditions: Nonfluent Aphasia|Stroke
Interventions: DRUG: levodopa/carbidopa|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral Intervention for Physical Activity and Sexual Dysfunction in Multiple Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis, Relapsing-Remitting|Sexual Dysfunction
Interventions: BEHAVIORAL: Behavioural intervention for physical activity for multiple sclerosis (BIPAMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Study of the NIDEK TONOREF III and the Haag-Streit Goldmann Manual Tonometer and Comparison of Pachymetry Values for NIDEK TONOREF III With the NIDEK CEM-530
Status: COMPLETED
Conditions: Intraocular Pressure
Interventions: DEVICE: Nidek Tonoref III|DEVICE: Haag-Streit Goldmann Manual Tonometer|DEVICE: NIDEK CEM-530
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Differences Between the Bayley-II and the Bayley-III in Very Preterm Infants at 2 Years
Status: COMPLETED
Conditions: Infant Development
Interventions: DIAGNOSTIC_TEST: Bayley Scales of Infant Development-II|DIAGNOSTIC_TEST: Bayley Scales of Infant Development-III
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Preventive Intervention to Promote Healthy Ageing
Status: RECRUITING
Conditions: Preventive Intervention
Interventions: BEHAVIORAL: Anging Wisely|BEHAVIORAL: Music therapy|BEHAVIORAL: Reminiscence therapy|BEHAVIORAL: Cognitive training|BEHAVIORAL: Educational activities
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression -COMBAT-SI
Status: RECRUITING
Conditions: Suicidal Ideation|Treatment-resistant Depression
Interventions: DEVICE: Accelerated Theta Burst Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomised Controlled Trial on the Effect of Post-exposure Oseltamivir Prophylaxis on Influenza Transmission in Nursing Homes
Status: UNKNOWN
Conditions: Influenza
Interventions: DRUG: Tamiflu (verum)|DRUG: Tamiflu placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Multi-Center Randomized Clinical Trial Irreversible Electroporation for the Ablation of Localized Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DEVICE: Irreversible Electroporation (Nanoknife)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tocilizumab in Patients With Rheumatoid Arthritis Who Have an Inadequate Response to Current Non-Biologic DMARDs
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tocilizumab [RoActemra/Actemra]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Active Immunization of Asymptomatic, HIV-Infected Individuals With Recombinant GP160 HIV-1 Antigen: A Phase I/II Study of Immunogenicity and Toxicity
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: gp160 Vaccine (MicroGeneSys)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: TACE Combined With Sorafenib and Tislelizumab for Advanced HCC
Status: COMPLETED
Conditions: Hepatocellular Carcinoma Non-resectable
Interventions: DRUG: TACE combined with sorafenib and tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Imaging in the Acute Phase of Transient Ischemic Attacks
Status: UNKNOWN
Conditions: Transient Ischemic Attack
Interventions: DIAGNOSTIC_TEST: Functional Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Long-term Intervention Effects of a Personalized, Home-based Exercise Program and Nutritional Advice, Along With the Inclusion of a Pre-workout Multi-ingredient Supplement on the Body Composition, Functional Capacity and Quality of Life of Middle-aged and Older Adults (40-70 Years)
Status: UNKNOWN
Conditions: Muscle Loss|Obesity|Obesity, Abdominal|Weight Loss|Happiness|Quality of Life|Self-Perception|Stress, Psychological
Interventions: DIETARY_SUPPLEMENT: Multi-ingredient Pre-workout supplement|OTHER: Progressive Resistance Training|BEHAVIORAL: Nutritional Patterns Guideline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Atrial Fibrillation Occurring Transiently With Stress (AFOTS)
Status: COMPLETED
Conditions: Atrial Fibrillation New Onset
Interventions: DIAGNOSTIC_TEST: 14 Day ECG Patch (Zio XT Patch, iRhythm Technologies)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Peginterferon Alfa-2a, Ribavirin, Amantadine/Placebo in Hepatitis C Virus (HCV)-Genotype-1-Infection (PRAMA)
Status: UNKNOWN
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Amantadine sulphate (in addition to standard treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study Of GW679769 Compared To Placebo In Women With Overactive Bladder
Status: COMPLETED
Conditions: Incontinence, Urinary and Urinary Bladder, Overactive|Overactive Bladder
Interventions: DRUG: GW679769 oral tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Broadband Sound and Sleep
Status: ACTIVE_NOT_RECRUITING
Conditions: Noise Exposure
Interventions: OTHER: Aviation Noise Only (AN)|OTHER: Pink noise, 50 dBA only (BN50)|OTHER: Aviation noise plus earplugs (AN+EP)|OTHER: Aviation noise plus white noise 40 dBA (AN+BN40)|OTHER: Aviation noise plus white noise 50 dBA (AN+BN50)|OTHER: Control Night (CTRL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Intrasynovial Digital Anesthesia in Trigger Finger
Status: RECRUITING
Conditions: Trigger Finger Disorder
Interventions: PROCEDURE: Dorsal webspace combined corticosteroid and anesthetic injection|PROCEDURE: Palmar combined corticosteroid and anesthetic injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CHESS-SAVE Score to Stratify Decompensation Risk in Compensated Advanced Chronic Liver Disease (CHESS2102)
Status: UNKNOWN
Conditions: Compensated Advanced Chronic Liver Disease
Interventions: PROCEDURE: Esophagogasrtoduodendoscopy and liver stiffness|PROCEDURE: hepatic venous pressure gradient
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Graded Exposure and Mindfulness Meditation for Patients Post-ACL Reconstruction
Status: RECRUITING
Conditions: Anterior Cruciate Ligament Injuries
Interventions: BEHAVIORAL: Graded Exposure and Mindfulness Meditation|BEHAVIORAL: Waitlist Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Increasing Security With End-zone Arterial Blood Pressure Monitoring During Surgery
Status: COMPLETED
Conditions: Catheterization, Peripheral
Interventions: PROCEDURE: Distal radial artery cannulation|PROCEDURE: Forearm radial artery cannulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety Study of Analgesia After Craniotomy Surgery With End Tidal (ET) Carbon Dioxide (CO2) Monitoring
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Fentanyl|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Adoptive T Regulatory Cell Transfer in Autoimmune Diseases.
Status: UNKNOWN
Conditions: Lupus Nephritis|Type 1 Diabetes Mellitus
Interventions: OTHER: autologous adoptive T regulatory cell transfer.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FLARE: Favipiravir +/- Lopinavir: A RCT of Early Antivirals
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Favipiravir|DRUG: Lopinavir/ Ritonavir|OTHER: Favipiravir Placebo|OTHER: Lopinavir/ Ritonavir Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare 2 Formulations of LY900014 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY900014 U-200|DRUG: LY900014 U-100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Glioma Supra Marginal Incision Trial
Status: RECRUITING
Conditions: High Grade Glioma
Interventions: PROCEDURE: Supramarginal resection|PROCEDURE: Conventional (i.e. GTR) resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety Study of PT009, PT008, and PT005 in Subjects With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: BFF MDI 320/9.6 μg|DRUG: BFF MDI 160/9.6 μg|DRUG: BFF MDI 80/9.6 μg|DRUG: BD MDI 320 μg|DRUG: FF MDI 9.6 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of T-DXd in HER2-mutant Advanced Lung Cancer Patients With Asymptomatic Brain Metastases
Status: NOT_YET_RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Trastuzumab deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KCNA3 and OTOP2 Gene Methylation Combined Detection Kit (Fluorescent PCR Method)
Status: COMPLETED
Conditions: Esophageal Neoplasms
Interventions: DIAGNOSTIC_TEST: KCNA3 and OTOP2 Gene Methylation Combined Detection Kit (Fluorescent PCR Method)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase II Study in Patients With Moderate to Severe Active Ulcerative Colitis.
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: SHR0302|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of AZD1775 (Adavosertib) Plus MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumours
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumours
Interventions: DRUG: AZD1775|DRUG: MEDI4736
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Effect of Different Doses of BI 685509 on Kidney Function in People With Diabetic Kidney Disease
Status: COMPLETED
Conditions: Diabetic Nephropathies
Interventions: DRUG: Placebo matching BI 685509|DRUG: BI 685509
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: to Study the Role of Retrograde Intrarenal Surgery in Management of Renal Stones
Status: RECRUITING
Conditions: Retrograde Intrarenal Surgery In Management Of Renal Stones
Interventions: DEVICE: Ureteroscope
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Static Apnea at High Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function
Status: RECRUITING
Conditions: Pain|Hypoxia|Hypercapnia|Apnea
Interventions: OTHER: Voluntary apnoea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Salivary ELISA for Hormone Monitoring in IVF Patients
Status: COMPLETED
Conditions: Infertility, Female|Reproductive Sterility
Interventions: DIAGNOSTIC_TEST: Determination of progesterone and oestradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies
Status: COMPLETED
Conditions: Cervical Cancer|Gastric Cancer|Stomach Cancer|Gastroesophageal Junction Cancer|Esophageal Cancer|Hepatocellular Carcinoma|Melanoma|Uveal Melanoma|Merkel Cell Carcinoma|Mesothelioma|MSI|Non-small Cell Lung Cancer|NSCLC|Ovarian Cancer|Squamous Cell Carcinoma of the Head and Neck|Small Cell Lung Cancer|Renal Cell Carcinoma|RCC|Triple-negative Breast Cancer|Urothelial Carcinoma|Mismatch Repair Deficiency
Interventions: DRUG: INCAGN02390
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritional Strategies to Increase Nitric Oxide Signaling in Raynaud's Phenomenon
Status: UNKNOWN
Conditions: Raynaud Phenomenon
Interventions: DIETARY_SUPPLEMENT: L-citrulline|DIETARY_SUPPLEMENT: Beetroot juice|DIETARY_SUPPLEMENT: L-citrulline placebo|DIETARY_SUPPLEMENT: Denitrated beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effectiveness of Reciprocal Imitation Teaching in Part C Early Intervention Settings (Sprout Study)
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Reciprocal Intervention Teaching (RIT)|BEHAVIORAL: Daily Routines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Vestibular Physiotherapy Against Multi-component Exercise in Functional Improvement in the Elderly
Status: COMPLETED
Conditions: Physical Therapy|Sports Physical Therapy|Exercise Therapy|Gait
Interventions: PROCEDURE: Experimental: VESTIBULAR EXERCISE|PROCEDURE: MULTICOMPONENT EXERCISE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Understanding the Relationship Between Inflammation and Insulin Resistance in the Adipose Tissue
Status: COMPLETED
Conditions: Obesity|Insulin Resistance
Interventions: PROCEDURE: Fat biopsy during scheduled abdominal surgery|PROCEDURE: Fat Aspiration|DIETARY_SUPPLEMENT: Fish Oil Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Associating Liver Partition With Portal Vein Ligation for Staged Hepatectomy (ALPPS) vs. Two-Stage Hepatectomy (TSH) for Marginally Resectable Colorectal Liver Metastases (CRLM)
Status: UNKNOWN
Conditions: Colon Cancer Liver Metastases|Liver Neoplasms|Liver Diseases|Secondary Malignant Neoplasm of Liver|Malignant Neoplasm of Large Intestine Metastatic to Liver|Hepatectomy|Surgery
Interventions: PROCEDURE: ALPPS|PROCEDURE: TWO STAGE HEPATECTOMY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolomic Analysis of Systemic Sclerosis
Status: RECRUITING
Conditions: Scleroderma (Limited and Diffuse)|Undifferentiated Connective Tissue Disease|Raynaud Disease|Vascular Disease|Healthy Control Subjects
Interventions: PROCEDURE: - Skin biopsy - Urine sample - Blood sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety Study of a Contact Lens With Ketotifen in Healthy, Normal Volunteers
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DEVICE: K-Lens (generic name not established) and Ketotifen|DEVICE: Placebo Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Outcomes of TAMIS-Total Mesorectal Excision Versus Transanal Loco-regional Excision for T2 Low Rectal Cancer
Status: UNKNOWN
Conditions: Low Rectal Cancer
Interventions: PROCEDURE: Transanal minimally invasive total mesorectal excision|PROCEDURE: transanal minimally invasive locoregional resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Oral Corticosteroids in the Treatment of Lumbar Stenosis
Status: UNKNOWN
Conditions: Spinal Stenosis of Lumbar Region
Interventions: DRUG: predinose oral|DRUG: placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Oxaliplatin and Taxotere in Metastatic Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: Oxaliplatin|DRUG: Taxotere
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of SBRT Combined With Cardonilizumab and Lenvastinib in the Treatment of Unresectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus
Status: RECRUITING
Conditions: Hepatocellular Carcinoma Non-resectable|Portal Vein Tumor Thrombus|Immune Checkpoint Inhibitors
Interventions: DRUG: Cadonilimab|RADIATION: Stereotactic radiotherapy|DRUG: Renvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early UVFP Management Based on Neurological Evidences (UVFP = Unilateral Vocal Fold Paralysis)
Status: COMPLETED
Conditions: Unilateral Vocal Cord Paralysis
Interventions: PROCEDURE: Acid hyaluronic injection laryngoplasty|BEHAVIORAL: Voice therapy|OTHER: Sham of injection|OTHER: Sham of voice therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Fluconazole, Bupropion, or Itraconazole on the Drug Levels and Safety of BMS-986235
Status: WITHDRAWN
Conditions: Healthy Participants
Interventions: DRUG: Fluconazole|DRUG: Bupropion|DRUG: Itraconazole|DRUG: BMS-986235
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photobiomodulation to Improve Cognition in TBI, With fMRI
Status: UNKNOWN
Conditions: Traumatic Brain Injury|Closed Head Injury|Cognitive Dysfunction
Interventions: DEVICE: Real LED Intervention|DEVICE: Sham LED Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Toxicity & Pharmacokinetics of 2 & 3-weekly Docetaxel in Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
Status: WITHDRAWN
Conditions: Metastatic Hormone-Sensitive Prostate Cancer
Interventions: DRUG: docetaxel 50mg/m2|DRUG: docetaxel 75mg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Obesity-hypoventilation Syndrome Study of Clinical Characteristics and Predictive Factors of Response to Treatment
Status: COMPLETED
Conditions: Obesity Hypoventilation Syndrome
Interventions: DEVICE: CPAP|DEVICE: Bilevel Support Ventilation (Non-Invasive Ventilation)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD22/CD19 CAR-T and Auto-HSCT Sandwich Strategy as Consolidation Therapy for B-ALL
Status: RECRUITING
Conditions: B-cell Acute Lymphoblastic Leukemia
Interventions: COMBINATION_PRODUCT: CD22/CD19 CAR T and auto-HSCT "sandwich" strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT