pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study to Evaluate the Effect of Botanical Dietary Supplements on Inflammation in Healthy People
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rose hips extract + blueberry/blackberry extract + resveravine|DRUG: Rose hips extract + blueberry/blackberry extract + Aframomum melegueta extract|DRUG: Rose hips extract + resveravine + Aframomum melegueta extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Randomized, Open-label Study on Helicobacter Pylori Eradication With Standard Triple Regimen Plus Acetazolamide
Status: WITHDRAWN
Conditions: H. Pylori Infection
Interventions: DRUG: Acetazolamide group|DRUG: Standard regimen group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Cardiovascular Effects of Ginger (Zingiber Officinale) in Patients With Type II Diabetes Mellitus
Status: COMPLETED
Conditions: Cardiovascular Benefits of Zingiber Officinale Roscoe in Patients With Type 2 Diabetes Mellitus Before and After 6 Weeks of add-on Therapy
Interventions: DIETARY_SUPPLEMENT: GINOFF1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Platinum-based Chemotherapy in Platinum-resistant Ovarian Cancer) (EPITOC)
Status: UNKNOWN
Conditions: Ovarian Cancer|Ovarian Neoplasms|Serous Adenocarcinoma|BRCA1 Mutation|BRCA2 Mutation|Chemotherapy
Interventions: DRUG: Platinum-Based Drug|DRUG: Conventional chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect Of Cryolipolysis On Visceral Adiposity Index In Polycystic Ovarian Syndrome Patients
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome
Interventions: DEVICE: 3max cool shaping device|DIETARY_SUPPLEMENT: low calolric diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin in Patients With Head and Neck Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Squamous Cell of the Head and Neck
Interventions: BIOLOGICAL: REOLYSIN®|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain
Status: NOT_YET_RECRUITING
Conditions: Pain|Sickle Cell Disease
Interventions: BEHAVIORAL: CBT+ Health coach|BEHAVIORAL: CBT w/o Health Coach ( self-guided)|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficiency and Safety of Quetiapine Fumarate in the Treatment of Acute Manic Patients With Bipolar Disorder.
Status: UNKNOWN
Conditions: Bipolar Disorder
Interventions: DRUG: Quetiapine fumarate|DRUG: Sodium valproate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Low Calorie and Low Nitrogen Parenteral Nutrition Support on the Clinical Outcome of Postoperative Patients
Status: COMPLETED
Conditions: Gastrointestinal Neoplasms|Postoperative Complications
Interventions: DRUG: low calorie, low nitrogen parenteral nutrition for patient with NRS score 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclosporine and Intense Pulsed Light for Dry Eye in Contact Lens Users
Status: RECRUITING
Conditions: Dry Eye|Contact Lens Complication
Interventions: DRUG: CycloSPORINE Ophthalmic|PROCEDURE: Intense Pulsed Light|PROCEDURE: Sham Intense Pulse Light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of EMS and TENS in Patients With Overactive Bladder
Status: UNKNOWN
Conditions: Overactive Bladder
Interventions: DEVICE: Electric Muscle Stimulation|DEVICE: Transcutaneous Electric Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Two Different Designs of Bausch & Lomb Contact Lenses
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Redesigned Purevision Contact Lens|DEVICE: PureVision Contact Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Preoperative Teriparatide Use on Insertional Torque of Pedicle Screws for Lumbar Fusion Surgery
Status: RECRUITING
Conditions: Osteoporosis|Fusion of Spine, Lumbar Region
Interventions: DRUG: Teriparatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Prospective, Randomized, Multicenter Study to Demonstrate the Superiority of the Barricaid to Discectomy for Primary Lumbar Disc Herniation
Status: ACTIVE_NOT_RECRUITING
Conditions: Lumbar Disc Herniation
Interventions: DEVICE: Barricaid|DEVICE: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Topical Botulinum Toxin Eyedrop on Palpebral Fissure
Status: RECRUITING
Conditions: Tears; Excess|Eyelid Spasm
Interventions: DRUG: Botulinum toxin|OTHER: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ABT-957 in Subjects With Mild-to-Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: ABT-957|OTHER: Placebo for ABT-957
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: UCN-01 and Fludarabine in Treating Patients With Recurrent or Refractory Lymphoma or Leukemia
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: DRUG: 7-hydroxystaurosporine|DRUG: fludarabine phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Canagliflozin in T1DM (Type 1 Diabetes Melitus) After Interruption of Continuous Subcutaneous Insulin Infusion
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: canagliflozin|OTHER: basal interruption without canagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Anticoagulation vs. Placebo for a First Symptomatic Isolated Distal Deep-vein Thrombosis (IDDVT)
Status: COMPLETED
Conditions: Distal (Calf) Deep-vein Thrombosis
Interventions: DRUG: nadroparine calcium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-label Trial of Imatinib Mesylate in Patients With Unresectable Recurrent Glioblastoma Multiforme Expressing PDGFR (Platelet Derived Growth Factor Receptors)
Status: TERMINATED
Conditions: Glioblastoma
Interventions: DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Safety and Efficacy of Fixed Dose Combination GSP 301 Nasal Spray (NS) in the Treatment of Perennial Allergic Rhinitis (PAR)
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis
Interventions: DRUG: GSP 301 NS|DRUG: GSP 301 Placebo NS pH 3.7|DRUG: GSP 301 Placebo NS pH 7.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral Effects of Drugs (Inpatient): 38
Status: TERMINATED
Conditions: Cocaine Use, Unspecified
Interventions: BEHAVIORAL: Craving Manipulation|DRUG: Cocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Using Decision Cycle for Person-Centered Glycemic Management in Type 2 Diabetes
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Decision Cycle for Person-Centered Glycemic Management|OTHER: Traditional diabetes self-management education
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Kinetics of Fluvoxamine and Digoxin in Subjects With Different MDR1 Genotypes
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: fluvoxamine|DRUG: Digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Glucomannan Soluble Fiber on Glucose Homeostasis in Patients With Roux En Y (RNY) Gastric Bypass Surgery
Status: COMPLETED
Conditions: Hypoglycemia
Interventions: DIETARY_SUPPLEMENT: glucomannan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project Nexus: Providing Online Counseling for Home-Based HIV Testing
Status: COMPLETED
Conditions: Couples
Interventions: BEHAVIORAL: Couples HIV Testing and Counseling (CHTC, CVCT)|BEHAVIORAL: at-home test kit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study Comparing Two Topicals in the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: FMX101 vehicle|OTHER: Hydro-alcohol solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Targeted Temperature Management on Cerebral Autoregulation in Patients With Neurocritical Diseases
Status: UNKNOWN
Conditions: Ischemic Stroke|Subarachnoid Hemorrhage, Aneurysmal|Sepsis|TBI (Traumatic Brain Injury)|ICH - Intracerebral Hemorrhage|HIE - Hypoxic - Ischemic Encephalopathy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203)
Status: RECRUITING
Conditions: Glioblastoma|Glioblastoma Multiforme|Glioblastoma, IDH-wildtype|Glioblastoma Multiforme, Adult
Interventions: BEHAVIORAL: Palliative Care|PROCEDURE: Tumor biopsy|PROCEDURE: Tumor resection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sorafenib, Pemetrexed, and Cisplatin in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Breast Cancer|Colorectal Cancer|Head and Neck Cancer|Lung Cancer|Mesothelioma|Pancreatic Cancer|Prostate Cancer|Sarcoma
Interventions: DRUG: cisplatin|DRUG: pemetrexed disodium|DRUG: sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Faroese Knee Cohort: Etiology and Long-term Implications of Trochlear Dysplasia and Patellar Dislocations.
Status: RECRUITING
Conditions: Patellar Dislocation|ACL Injury|Meniscus Lesion|Trochlear Dysplasia
Interventions: OTHER: No intervention is made
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparison of the C-mac and Bonfils Intubation Fibrescope
Status: UNKNOWN
Conditions: Intubation|Airway
Interventions: DEVICE: Karl Storz C-MAC|DEVICE: Bonfils Intubation Fibrescope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of VR and AR on Pruritus
Status: COMPLETED
Conditions: Chronic Renal Insufficiency|Pruritus|Itch
Interventions: OTHER: Autogenic Relaxation|OTHER: virtual reality game application|OTHER: kidney function narration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ascending Dose Study of FrontlineODP™ Spray Dried Plasma
Status: ENROLLING_BY_INVITATION
Conditions: Coagulopathy|Hemorrhage
Interventions: COMBINATION_PRODUCT: Autologous Spray Dried Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study Investigating OCT, Multifocal ERG, and Microperimetry in Monthly Versus PRN Ranibizumab in Neovascular Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Neovascular Age Related Macular Degeneration
Interventions: DEVICE: OCT, Multifocal ERG, Microperimetry|DRUG: Ranibizumab Ophthalmic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Response to Cabergoline and Pasireotide in Non-functioning Pituitary Adenomas and Resistant Prolactinomas
Status: COMPLETED
Conditions: Non-functioning Pituitary Adenomas|Prolactinomas
Interventions: DRUG: Pasireotide|DRUG: cabergoline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Community-based Treatment of Chronic Hepatitis C Monoinfection and Coinfection With HIV in the District of Columbia
Status: COMPLETED
Conditions: HCV HIV
Interventions: DRUG: Ledipasvir 90 mg and Sofosbuvir 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Janssen - Glucose Regulation/Risp/Olanz
Status: COMPLETED
Conditions: Schizophrenia|Type 2 Diabetes Mellitus
Interventions: DRUG: Risperidone, Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficiency and Safety of Zinc Sulphate to Reduce the Duration of Acute Diarrheal Disease Between 6 and 59 Months of Age
Status: COMPLETED
Conditions: Diarrhoea;Acute|Diarrhea, Infantile
Interventions: DIETARY_SUPPLEMENT: zinc sulfate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Insulin Resistance and Mild Cognitive Impairment (IRMCI) Study
Status: TERMINATED
Conditions: Mild Cognitive Impairment|Insulin Resistance|Diabetes Mellitus, Type 2
Interventions: DRUG: Metformin|BEHAVIORAL: Intensive Lifestyle Intervention|BEHAVIORAL: Standard LIfestyle Recommendation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Post Facilitation Stretch and Maitland Mobilization in Post-traumatic Stiff Elbow
Status: COMPLETED
Conditions: Post Traumatic Stiff Elbow
Interventions: OTHER: Maitland Mobilization|OTHER: Post facilitation stretch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Modern Pain Neuroscience Applied to Chronic Pain in Patients With Chronic Whiplash Associated Disorders
Status: COMPLETED
Conditions: Whiplash
Interventions: BEHAVIORAL: Modern pain neuroscience approach|BEHAVIORAL: Usual care evidence-based physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stop Hep B @ Birth
Status: UNKNOWN
Conditions: Hepatitis B
Interventions: DRUG: Tenofovir Disoproxil Fumarate 300 mg daily; HBV birth dose vaccine; hepatitis B immune globulin (HBIG)|DRUG: Regular Myanmar treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Modified Brostrӧm Procedure With and Without Possible Arthroscopy for Lateral Ankle Instability
Status: UNKNOWN
Conditions: Lateral Ankle Instability
Interventions: PROCEDURE: MBP plus arthroscopy (Group A)|PROCEDURE: MBP alone (Group B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults
Status: NOT_YET_RECRUITING
Conditions: Aging
Interventions: DRUG: Psilocybin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Aquatic Exercises VS Core Strengthening on Disability, Flexibility and Postural Stability in Weightlifters.
Status: RECRUITING
Conditions: Hydrotherapy|Core Stability|Resistance Training|Low Back Pain
Interventions: OTHER: Aquatic exercises|OTHER: Core strengthening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Ixazomib, ONC201, and Dexamethasone in Relapsed/Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: ONC201|DRUG: Ixazomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Olanzapine Versus Aprepitant Based Antiemetic Regimen for High Emetic Chemotherapy
Status: UNKNOWN
Conditions: Antiemetic for Highly Emetogenic Chemotherapy
Interventions: DRUG: aprepitant|DRUG: olanzapine 10 mg|DRUG: olanzapine 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: European Quality of Care Pathways Study on the Effect of Care Pathways on Interprofessional Teamwork (EQCP-TEAM)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Proximal Femur Fracture
Interventions: BEHAVIORAL: Care pathway.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Laboratory-Treated T Cells After Second-Line Chemotherapy in Treating Patients With HER2/Neu-Negative Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: HER2Bi-armed activated T cells|DRUG: Cyclophosphamide|OTHER: Laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transversus Thoracic Muscle Plane Combined With Pectoral Nerves Block for Breast Cancer Surgery
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: the combination of transversus thoracic muscle plane and pectoral nerves blocks|PROCEDURE: the pectoral nerves block only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Oral Immunomodulator in Tuberculosis (TB) and TB/HIV Patients
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: V-5 immunitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-Label Study of the Long Term Safety of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis (IPF)
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: pirfenidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: QUILT-3.044: NANT Non-small Cell Lung Cancer (NSCLC) Vaccine: Combination Immunotherapy in Subjects With NSCLC Who Have Progressed After Treatment With PD-1/PD-L1 Inhibitors
Status: WITHDRAWN
Conditions: Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: avelumab|BIOLOGICAL: Bevacizumab|DRUG: Capecitabine|DRUG: Cisplatin|DRUG: cyclophosphamide|DRUG: 5-Fluorouracil (5-FU)|DRUG: fulvestrant|DRUG: leucovorin|DRUG: nab paclitaxel|BIOLOGICAL: nivolumab|DRUG: Lovaza|DRUG: Oxaliplatin|RADIATION: Stereotactic Body Radiation Therapy|BIOLOGICAL: ALT-803|BIOLOGICAL: ETBX-011|BIOLOGICAL: ETBX-021|BIOLOGICAL: ETBX-051|BIOLOGICAL: ETBX-061|BIOLOGICAL: GI-4000|BIOLOGICAL: GI-6207|BIOLOGICAL: GI-6301|BIOLOGICAL: haNK
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed Plus Tarceva as Salvage Treatment in EGFR Overexpressed Metastatic Colorectal Cancer Patients Who Were Failed After Standard Chemotherapy
Status: COMPLETED
Conditions: Colo-rectal Cancer
Interventions: DRUG: Pemetrexed|DRUG: Tarceva 100Mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACTIV-6: COVID-19 Study of Repurposed Medications - Arm D (Ivermectin 600)
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Ivermectin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib Combination Study of Rituximab, TinostamustinEAnd CHeckpoint Inhibition With Pembrolizumab in Relapsed/Refractory DLBCL
Status: WITHDRAWN
Conditions: Relapsed or Refractory Diffuse Large B-cell Lymphoma
Interventions: DRUG: Tinostamustinein|DRUG: Pembrolizumab|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine With/Out Erlotinib in Unresectable Locally Advanced/Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: erlotinib hydrochloride|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interleukin-2 With or Without Histamine Dihydrochloride in Treating Patients With Metastatic Kidney Cancer
Status: UNKNOWN
Conditions: Kidney Cancer
Interventions: BIOLOGICAL: aldesleukin|DRUG: histamine dihydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Potency of Inhaled Corticosteroids
Status: COMPLETED
Conditions: Asthma|Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: fluticasone 25, 50, 100, 200 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel and Capecitabine in Advanced Gastric Cancer
Status: COMPLETED
Conditions: Stomach Neoplasm|Neoplasm Metastasis
Interventions: DRUG: Docetaxel|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Multiple Doses of Convalescent Plasma in Mechanically Intubated Patients With COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Multiple doses of anti-SARS-CoV-2 Convalescent Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Ascending Multi-Dose, Tolerance and Pharmacokinetic Study in Obese or Overweight Type 2 Diabetic Volunteers
Status: COMPLETED
Conditions: Diabetes Mellitus|Obesity
Interventions: DRUG: Trodusquemine (MSI-1436)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of a New Critical Pathway for Treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI)
Status: COMPLETED
Conditions: Bacterial Infections|Acute Bacterial Skin and Skin Structure Infection
Interventions: DRUG: Dalbavancin|DRUG: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Recombinant Human Erythropoietin on Platelet Function in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Recombinant human erythropoietin alfa (drug)|DRUG: Aspirin (drug)|DRUG: Clopidogrel (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Continuous Glucose Monitoring in Total Knee Arthroplasty With Preoperative High Dose Dexamethasone
Status: UNKNOWN
Conditions: Diabetes|Knee Osteoarthritis
Interventions: PROCEDURE: Intraarticular injection of dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Silicon Phthalocyanine 4 and Photodynamic Therapy in Stage IA-IIA Cutaneous T-Cell Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Stage I Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IA Mycosis Fungoides/Sezary Syndrome|Stage IB Mycosis Fungoides/Sezary Syndrome|Stage II Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IIA Mycosis Fungoides/Sezary Syndrome
Interventions: DRUG: silicon phthalocyanine 4|DRUG: photodynamic therapy|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Clinical Study of Drug-coating Balloon Strategy and Drug-eluting Stent Strategy
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: paclitaxel DCB|DEVICE: DES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Fibre Products on Appetite and Weight
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Propionate ester|DIETARY_SUPPLEMENT: Inulin|DIETARY_SUPPLEMENT: Cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Vincristine, Carboplatin, and Etoposide or Observation Only in Treating Patients Who Have Undergone Surgery for Newly Diagnosed Retinoblastoma
Status: COMPLETED
Conditions: Intraocular Retinoblastoma
Interventions: DRUG: liposomal vincristine sulfate|DRUG: carboplatin|DRUG: etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CA 125 Levels in Treating Patients With Relapsed Advanced Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer Who Are Receiving Tamoxifen
Status: UNKNOWN
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: tamoxifen citrate|OTHER: diagnostic laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Riluzole Orodispersible Film Replicate Bioavailability
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Riluzole 50 mg Oral Film|DRUG: Rilutek 50Mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Glaucoma Nicotinamide Trial
Status: RECRUITING
Conditions: Glaucoma
Interventions: DIETARY_SUPPLEMENT: Nicotinamide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized Nutrition in Young Adults: The Ability of Genetic Information to Motivate Changes in Omega-3 Consumption
Status: COMPLETED
Conditions: Health Behaviour|Nutrition Intervention|Impaired Health
Interventions: GENETIC: Genetic information and Omega-3 fat intake|BEHAVIORAL: General Nutrition related to Omega-3 fats
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gonadotropin Releasing Hormone Agonist (GnRHa) Versus Estrogen and Progesterone for Luteal Support in High Responders
Status: UNKNOWN
Conditions: Pregnancy Early|Miscarriage|Ovarian Hyperstimulation Syndrome
Interventions: DRUG: Synarel, 0.2 Mg/Inh Nasal Spray|DRUG: Estrofem|DRUG: Utrogestan|DRUG: Hydroxyprogesterone Caproate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of CNV With Aflibercept Combined With Pranoprofen Eye Drops or Nutraceutical Support With Omega-3
Status: COMPLETED
Conditions: Macular Edema
Interventions: DRUG: Aflibercept Injection [Eylea]|DRUG: Pranoprofen Eyedrops|DRUG: Omega-3 Supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Access Safety, Tolerability, Pharmacokinetics(PK) and Pharmacodynamics(PD) of Orally Administered GCC-4401C in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: GCC-4401C|DRUG: Rivaroxaban|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Weight Stigma in Women Who Are Obese: Assessing How an Acute Exposure to Stigma Negatively Impacts Cardiovascular Health
Status: COMPLETED
Conditions: Stigma, Social|Obesity|Cardiovascular Disease Risk Factor|Blood Pressure
Interventions: BEHAVIORAL: Stigma Video Exposure|BEHAVIORAL: Neutral video exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Acupuncture for Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Status: COMPLETED
Conditions: Chronic Prostatitis With Chronic Pelvic Pain Syndrome
Interventions: DEVICE: Acupuncture|DEVICE: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Varlilumab and IMA950 Vaccine Plus Poly-ICLC in Patients With WHO Grade II Low-Grade Glioma (LGG)
Status: TERMINATED
Conditions: Glioma|Malignant Glioma|Astrocytoma, Grade II|Oligodendroglioma|Glioma, Astrocytic|Oligoastrocytoma, Mixed
Interventions: BIOLOGICAL: IMA950|BIOLOGICAL: poly-ICLC|BIOLOGICAL: Varlilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Effectiveness and Safety of Amberen and Smart B in Perimenopausal Women.
Status: COMPLETED
Conditions: Perimenopause, Climacteric Syndrome
Interventions: DIETARY_SUPPLEMENT: Amberen|DIETARY_SUPPLEMENT: Smart B|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Recombinant Interleukin-7 (CYT107) to Restore Absolute Lymphocyte Counts in Sepsis Patients
Status: TERMINATED
Conditions: Sepsis, Severe
Interventions: BIOLOGICAL: CYT107|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Scar Location and Acute Haemodynamic Response to MultiPoint Pacing Study in Patients With Ischemic Cardiomyopathy
Status: TERMINATED
Conditions: Heart Failure|Ischemic Cardiomyopathy
Interventions: DIAGNOSTIC_TEST: Cardiac MRI with gadolinium contrast|DIAGNOSTIC_TEST: 3D reconstruction and location of coronary sinus venous system relative to myocardial scar|DIAGNOSTIC_TEST: Acute haemodynamic measurements during CRT implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acetabular Shell Positioning Using Patient Specific Instruments
Status: COMPLETED
Conditions: Osteoarthritis, Hip|Rheumatoid Arthritis|Avascular Necrosis
Interventions: PROCEDURE: Acetabular positioning system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Fluzone® Quadrivalent, Fluzone® Intradermal, and Fluzone® High-Dose Influenza Virus Vaccines in Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluzone® Quadrivalent, Influenza Virus Vaccine (2013-2014 formulation),|BIOLOGICAL: Fluzone® Intradermal, Influenza Virus Vaccine (2013-2014 formulation),|BIOLOGICAL: Fluzone® Quadrivalent, Influenza Virus Vaccine (2013-2014 formulation),|BIOLOGICAL: Fluzone® High-Dose, Influenza Virus Vaccine (2013-2014 formulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The LINFU® U.S. Registry in Patients With Clinical Signs and/or Symptoms of Disease
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Cancer|Jaundice|Abdominal Neoplasm
Interventions: DIAGNOSTIC_TEST: LINFU® (Low Intensity Non-Focused Ultrasound excitation of the pancreas)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Efficacy and Safety of Bendamustine Hydrochloride Injection
Status: COMPLETED
Conditions: Indolent B-Cell Non-Hodgkin's Lymphomas
Interventions: DRUG: Bendamustine hydrochloride injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: preGallstep - A Clinical Pilot Trial
Status: RECRUITING
Conditions: Pancreatitis|Cholangitis|Cholecystitis; Gallstone|Jaundice, Obstructive
Interventions: PROCEDURE: LCBDE + LC|PROCEDURE: ERC + LC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Addressing Depression and Anxiety Symptoms in Patients With Inflammatory Bowel Disease
Status: UNKNOWN
Conditions: Inflammatory Bowel Diseases|Crohn Disease|Ulcerative Colitis|Depression|Anxiety
Interventions: BEHAVIORAL: Web-Based Cognitive Behavioral Therapy|OTHER: Short Questionnaires|BEHAVIORAL: Nurse Monitoring|OTHER: Detailed Questionnaires|OTHER: Screening Form
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Transtheoretical Model-Based Motivational Interviewing on Postpartum Contraception
Status: RECRUITING
Conditions: Supportive Care
Interventions: BEHAVIORAL: Motivational interviewing group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Functions, Physical Activity and Employment for Individuals With MS: A Pilot Feasibility Study
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: CoreDISTparticipation|BEHAVIORAL: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cystoscopy in Females: Is There a Difference Between Rigid and Flex Cystoscopy, and Does it Require Local Anasthesia?
Status: COMPLETED
Conditions: Hematuria|Dysuria|Recurrent Uti
Interventions: DRUG: Lidocaine|DRUG: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Single-Dose Bioavailability Study of Two Formulations of Ibuprofen and Pseudoephedrine Hydrochloride Tablets
Status: COMPLETED
Conditions: Pain, Head|Pain, Acute|Pain, Back|Fever
Interventions: DRUG: Ibuprofen/Pseudoephedrine HCl 200/30 mg Film-Coated Tablets|DRUG: RhinAdvil Rhume 200 mg/30 mg Film-Coated Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Valacyclovir Hydrochloride in the Prevention of Life-Threatening Cytomegalovirus Disease in HIV-Infected Patients
Status: COMPLETED
Conditions: Cytomegalovirus Infections|HIV Infections
Interventions: DRUG: Valacyclovir hydrochloride|DRUG: Acyclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Caregiver Adverse Childhood Experiences (ACEs) in Pediatric Primary Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Child Development
Interventions: BEHAVIORAL: Training for ACEs and study procedures|BEHAVIORAL: Training on study procedures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of RRx-001 in the Attenuation of Oral Mucositis in Patients Receiving Chemoradiation for the Treatment of Oral Cancers
Status: COMPLETED
Conditions: Oral Mucositis
Interventions: DRUG: RRx-001|DRUG: Cisplatin for injection|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Driving Pressure and Postoperative Pulmonary Complications
Status: COMPLETED
Conditions: One-Lung Ventilation|Postoperative Respiratory Complications|Driving Pressure
Interventions: OTHER: Driving Pressure Limited Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacogenomic-Guided Antidepressant Drug Prescribing in Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Depression|Anxiety|Generalized Anxiety Disorder|Depressive Disorder|Major Depressive Disorder|Cancer
Interventions: DIAGNOSTIC_TEST: DNA-guided choice of therapy|OTHER: Clinical management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of BRS and LRS on Postoperative Acute Kidney Injury
Status: RECRUITING
Conditions: Acute Kidney Injury
Interventions: DRUG: Sodium Bicarbonate Ringer's Injection|DRUG: Sodium Lactated Ringer's Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Resettled Refugee Families for Healing
Status: NOT_YET_RECRUITING
Conditions: Stress Disorders, Post-Traumatic|Depression|Antisocial Personality Disorder|Anxiety|Aggressive Behavior
Interventions: BEHAVIORAL: RRF4H Combination Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial of Rehabilitation Therapy in Older Acute Heart Failure Patients
Status: COMPLETED
Conditions: Acute Decompensated Heart Failure
Interventions: BEHAVIORAL: multi-domain rehabilitation intervention|BEHAVIORAL: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TS Stratified Chemotherapy and VEGF Inhibition in Non-Squamous Non-Small Cell Lung Cancer - Stage IV
Status: WITHDRAWN
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zoledronic Acid or Methylprednisolone for Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus
Status: COMPLETED
Conditions: Charcot Arthropathy|Diabetes Complications
Interventions: DRUG: Zoledronic Acid|DRUG: Methylprednisolone|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics Study of VALTOCO® in Pediatric Subjects With Epilepsy
Status: ACTIVE_NOT_RECRUITING
Conditions: Epilepsy
Interventions: DRUG: Diazepam Nasal Spray [Valtoco]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
Status: COMPLETED
Conditions: Liver Cancer
Interventions: PROCEDURE: CO Testing Pre/Post Hepatic Resection|DIAGNOSTIC_TEST: ABG Testing Pre/Post Hepatic Resection|DIAGNOSTIC_TEST: CT Evaluations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Quality of Life in Patients With Unresectable Hilar Cholangiocarcinoma on Palliative Metallic Stent Versus Plastic Stent
Status: UNKNOWN
Conditions: Unresectable Hilar Cholangiocarcinoma
Interventions: DEVICE: biliary stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Show a Superior Benefit in Terms of Reduction of Ranibizumab Injections in Patients Receiving Ranibizumab Plus Laser Photocoagulation Combination Therapy Without Loss of Efficacy and Safety
Status: COMPLETED
Conditions: Macular Edema Secondary to Branch Retinal Vein Occlusion (BRVO)
Interventions: BIOLOGICAL: Ranibizumab|RADIATION: Grid&Direct short pulse laser photocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liothyronine (T3) for Bipolar Depression
Status: COMPLETED
Conditions: Depression|Bipolar Disorder
Interventions: DRUG: Liothyronine (T3)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial Comparing Laparoscopic-assisted Rectosigmoid Resection Versus Laparoscopic Rectosigmoid Resection With Transrectal Specimen Retrieval
Status: RECRUITING
Conditions: Symptomatic Recurrent Diverticular Disease|Benign Adenomatous Sigmoidal Polyp, Requiring Surgery|Early Non-transmural Sigmoidtumor
Interventions: PROCEDURE: rectosigmoid resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy, Safety and Tolerability of IMU-838 in Patients With Relapsing Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: IMU-838 tablets|DRUG: Placebo matching IMU-838 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of Gemcitabine Plus a Cytotoxic Agent Versus Two Cytotoxic Agents
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: gemcitabine|DRUG: capecitabine|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modified Melanoma Vaccine for High Risk or Low Residual Disease Patients
Status: UNKNOWN
Conditions: High Risk HLA-A2+ Melanoma|Metastatic Disease
Interventions: BIOLOGICAL: Melanoma vaccine modified to express HLA A2/4-1BB ligand
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Daratumumab in Patients With Anti-Aquaporin 4 Antibody Positive Neuromyelitis Optica Spectrum Disorders
Status: RECRUITING
Conditions: Neuromyelitis Optica|Neuromyelitis Optica Spectrum Disorder|NMO Spectrum Disorder
Interventions: DRUG: Daratumumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of GX-188E Administered Via EP Plus GX-I7 or Imiquimod.
Status: UNKNOWN
Conditions: Cervical Intraepithelial Neoplasia 3
Interventions: BIOLOGICAL: GX-188E, GX-I7|BIOLOGICAL: GX-188E, Imiquimod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Montelukast in Seasonal Allergic Rhinitis - Spring 2001 Study (0476-235)
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: montelukast sodium|DRUG: Comparator: loratadine|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation
Status: RECRUITING
Conditions: Covid19|Olfactory Dysfunction
Interventions: PROCEDURE: Biopsy and Cytobrush
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE