pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety, Tolerability, and Pharmacokinetics of XXB750 in Healthy Participants
Status: COMPLETED
Conditions: XXB750 in Healthy Participants
Interventions: DRUG: XXB750|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Preoperative Versus Postoperative Start With Thromboprophylaxis in THA (Total Hip Arthroplasty)
Status: COMPLETED
Conditions: Arthritis of the Hip|Transfusion Related Complications|Infection|Wound Discharge
Interventions: DRUG: dalteparin 5000 IU s.c.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of DNK333 in Atopic Dermatitis Patients
Status: COMPLETED
Conditions: Pruritus in Patients With Atopic Dermatitis
Interventions: DRUG: DNK333 5 mg|DRUG: Placebo to 5 mg|DRUG: DNK333 25 mg|DRUG: Placebo to 25 mg|DRUG: DNK333 100 mg|DRUG: Placebo to 100 mg|DRUG: Betamethasone 4 mg|DRUG: DNK333 1mg|DRUG: Placebo to 1mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics on Sleep Among Adults Study
Status: COMPLETED
Conditions: Sleep Disturbance|Sleep Patterns
Interventions: DIETARY_SUPPLEMENT: Probiotic formulation|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PF-07225570 Alone or in Combination With an Anti-PD-1 Antibody in Recurrent Non-muscle Invasive Bladder Cancer (NMIBC)
Status: WITHDRAWN
Conditions: Bladder Cancer
Interventions: DRUG: PF-07225570|DRUG: sasanlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mirtazapine for Chronic Insomnia in Older Adults
Status: COMPLETED
Conditions: Chronic Insomnia
Interventions: DRUG: Mirtazapine 7.5 MG Oral Tablet once daily at bedtime|DRUG: Placebo oral tablet once daily at bedtime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Autologous Cluster of Differentiation 34 (CD34+) Hematopoietic Progenitor Cells Transduced With Placebo or an Anti- Human Immunodeficiency Virus Type 1 (HIV-1) Ribozyme (OZ1) in Participants With HIV-1 Infection
Status: COMPLETED
Conditions: HIV-1
Interventions: OTHER: Placebo|GENETIC: OZ1|GENETIC: CD34+ cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ramelteon in Adults With Chronic Insomnia
Status: COMPLETED
Conditions: Balance
Interventions: DRUG: Ramelteon|DRUG: Zopiclone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel, Bevacizumab and Androgen Deprivation Therapy After Definitive Local Therapy for Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Docetaxel|DRUG: Bevacizumab|DRUG: ADT|DRUG: Bicalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Efficacy of BCT197A2201 in COPD Patients Presenting With an Exacerbation
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: BCT197|DRUG: Prednisone placebo|DRUG: BCT197 placebo|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of RF Turbinoplasty in Polypoid Change of Middle Turbinates
Status: UNKNOWN
Conditions: Nasal Polyposis|Sinusitis
Interventions: PROCEDURE: middle turbinate Radio Frequency (RF) turbinoplasty|PROCEDURE: middle turbinate resection|PROCEDURE: middle turbinate medialization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: SHR-1701 for Consolidation Therapy After Concurrent Chemoradiotherapy in Inoperable Stage III NSCLC
Status: NOT_YET_RECRUITING
Conditions: NSCLC, Stage III
Interventions: DRUG: SHR-1701
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Telerehabilitation Methods on Pain, Functional Limitation, Muscle Strength, Balance, and Quality of Life in Patients With Meniscus Degeneration
Status: UNKNOWN
Conditions: Meniscus; Degeneration
Interventions: OTHER: Exercise Therapy via video conference|OTHER: Exercise Therapy via mobile application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Plate Fixation of Distal Femur Fractures: A Protocol for a Study of Two Plate Options
Status: COMPLETED
Conditions: Femoral Fractures
Interventions: DEVICE: 95-degree Angled Blade Plate|DEVICE: 4.5mm Condylar Locking Plate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Evaluate the Efficacy and Safety of Aspherical Soft Contact Lens in Myopia Control
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: soft contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Prandial Treatment Adjustment Effect Via Continuous Glucose Monitoring on Type 2 Diabetes Mellitus (DM) Patients Uncontrolled With a Basal Insulin or Premix Once a Day
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: INSULIN GLARGINE (HOE901)|DRUG: INSULIN GLULISINE (HMR1964)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Baricitinib, Methotrexate as Monotherapy or Combination in the Treatment of Rheumatoid Arthritis - an Open Label Randomized Clinical Trial
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Baricitinib 2 MG|DRUG: Methotrexate 25mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acceleration of Alignment of Crowded Lower Anterior Teeth
Status: COMPLETED
Conditions: Malocclusion, Angle Class I|Crowded Teeth
Interventions: PROCEDURE: periodontally accelerated osteogenic orthodontics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Three Newly Developed 2-piece Convex Base-plates in Subjects With Ileostomy
Status: COMPLETED
Conditions: Ileostomy - Stoma
Interventions: DEVICE: Coloplast Test 1|DEVICE: Coloplast Test 2|DEVICE: Coloplast Test 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Exenatide Once Weekly for Smoking Cessation
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Exenatide|DRUG: NRT|BEHAVIORAL: Counseling|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Venetoclax (ABT-199) in Multiple Myeloma Subjects Who Are Receiving Bortezomib and Dexamethasone as Standard Therapy
Status: COMPLETED
Conditions: Relapsed/Refractory Multiple Myeloma
Interventions: DRUG: Venetoclax|DRUG: Bortezomib|DRUG: Dexamethasone|DRUG: Placebo for venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography (PET) Imaging of Pancreatic Beta-Cell Mass in Healthy and Type 1 Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: 18F-FP-DTBZ (18F-AV-133)|BIOLOGICAL: Arginine-hydrochloride
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Motivation Skills Training (MST)
Status: RECRUITING
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: BEHAVIORAL: Motivation Skills Training|BEHAVIORAL: Healthy Behaviors Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IMPACT: A Randomized WOO Study of Novel Therapeutic Agents in Women Triaged to Primary Surgery for EOC
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Metformin|DRUG: Acetylsalicylic acid|DRUG: Olaparib|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Social & Affective Cognition in Alzheimer's Disease & Associated Disorders
Status: NOT_YET_RECRUITING
Conditions: Alzheimer's Disease|Frontotemporal Degeneration (Semantic & Behavioral Variants)
Interventions: OTHER: SCANN
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Low Level Laser Therapy (LLLT) for the Treatment of Hand Osteoarthritis.
Status: RECRUITING
Conditions: Low Level Laser Therapy|Osteoarthritis|Family Medicine|Pain Management|Integrative Medicine
Interventions: DEVICE: Phoenix Thera-Lase System|DEVICE: SHAM Phoenix Thera-Lase System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Of Chemokine Coreceptor 5 (CCR5) Antagonist GW873140 In R5/X4-Tropic Treatment-Experienced HIV-Infected Subjects
Status: TERMINATED
Conditions: HIV Infection
Interventions: DRUG: GW873140
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Open Label Comparative Study On Celecoxib Efficacy And Safety Vs Non-Selective NSAID In Acute Pain Due To Ankle Sprain
Status: COMPLETED
Conditions: Ankle Sprain
Interventions: DRUG: Non-selective NSAIDS|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study to Evaluate Robot Assisted Total Knee Replacement Outcomes
Status: UNKNOWN
Conditions: Primary Osteoarthritis of Knee Nos
Interventions: PROCEDURE: Robot Assisted Total Knee Replacement|PROCEDURE: Traditional Total Knee Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Does Fluoxetine Have an Effect on the CNS CRF Systems in Women Abused in Childhood?
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Fluoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Early Versus Delayed Administration of Everolimus in de Novo Renal Transplant Patients
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: Everolimus (RAD001)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy/Safety of Octreotide Acetate in Patients With Uncontrolled Acromegaly
Status: COMPLETED
Conditions: Acromegaly
Interventions: DRUG: Octreotide acetate 30 mg suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study to Compare the Treatments of a Combination of Elzasonan With Zoloft, to Zoloft Alone, or Placebo in People With Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Sertraline and Elzasonan Combination|DRUG: Sertraline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Clinical Impact of Patient-ventilator Asynchrony
Status: RECRUITING
Conditions: Chronic Respiratory Failure|Non-invasive Ventilation|Asynchrony Between Patient and Ventilator|Efficacy and Tolerance of Non-invasive Ventilation|Clinical Repercussions of the Various Patient-ventilator Asynchronies
Interventions: DEVICE: Transcutaneous Capnography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of JNJ-55308942 in the Treatment of Bipolar Depression
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: JNJ-55308942|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aerobic Training On Spasticity And Gross Motor Function In Children With Diplegic Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: Aerobic Training|OTHER: Conventional Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Levothyroxine Supplementation for Heart Transplant Recipients
Status: RECRUITING
Conditions: Heart Transplant Failure|Heart Transplant Infection
Interventions: DRUG: Levothyroxine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Atorvastatin and Endothelial Function in Type 2 Diabetes Mellitus (ATTEND-Study)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: In Situ Simulation Training in Lifeguard Organisations
Status: RECRUITING
Conditions: Drowning|Drowning, Near|Drowning and Nonfatal Submersion|Drowning/Submersion|Drowning and Submersion While in Natural Water
Interventions: OTHER: In situ simulation assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety/Efficacy Study of SGN-30 (Antibody) in Patients With Refractory or Recurrent CD30+ Hematologic Malignancies
Status: COMPLETED
Conditions: Hodgkin Disease|Lymphoma, Large-Cell|Sarcoma, Kaposi|Lymphoma, T-Cell, Cutaneous|Lymphoma, B-Cell
Interventions: DRUG: SGN-30 (monoclonal antibody)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Treadmill Walk on Chronic Low Back Pain
Status: UNKNOWN
Conditions: Chronic Low Back Pain
Interventions: BEHAVIORAL: Warm-up|BEHAVIORAL: Main exercise|BEHAVIORAL: Cool down|BEHAVIORAL: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Health Behaviors Through Telephone Linked Care
Status: COMPLETED
Conditions: Diet|Physical Activity|Smoking|Alcohol Abuse
Interventions: BEHAVIORAL: Telephone Linked Care - Behavior Change Counseling System|BEHAVIORAL: Telephone-linked behavioral counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Continued Nutritional Support at Hospital Discharge on Mortality, Frailty, Functional Outcomes and Recovery
Status: RECRUITING
Conditions: Malnutrition
Interventions: DIETARY_SUPPLEMENT: nutritional supplement|OTHER: individualized nutritional guidelines|OTHER: general nutritional information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of Oral Netupitant and Palonosetron for the Prevention of Nausea and Vomiting
Status: COMPLETED
Conditions: Chemotherapy-Induced Nausea and Vomiting
Interventions: DRUG: Netupitant and Palonosetron|DRUG: Aprepitant|DRUG: Palonosetron|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neuro-Cardiac-Guided Transcranial Magnetic Stimulation: Replication and Dose-response.
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: Transcranial magnetic stimulation (TMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A 6-year Follow-up Study of the Effect of Neurorehabilitation Training in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Follow up|Parkinson Disease|Rehabilitation
Interventions: OTHER: Exercise+FU|OTHER: Active Comparator group Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Oral Lichen Planus With Paeoniflorin and Photodynamic Therapy
Status: RECRUITING
Conditions: Oral Lichen Planus
Interventions: DRUG: total glucosides of paeony treatment|OTHER: photodynamic therapy treatment|OTHER: glucosides of paeony and photodynamic therapy combined treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Community-based Participatory Intervention to Change Attitudes Towards Female Circumcision Among Somali Immigrants in Sweden
Status: COMPLETED
Conditions: Female Circumcision|Female Genital Mutilation/Cutting
Interventions: BEHAVIORAL: Attitude change towards female circumcision|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics of Cidofovir During Continuous Venovenous Hemofiltration
Status: COMPLETED
Conditions: Cytomegalovirus Retinitis|Acute Renal Failure
Interventions: OTHER: Cidofovir pharmacokinetics
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Use of Misoprostol for Intrauterine Device (IUD) Insertion in Nulliparous Women
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Misoprostol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intensive Statin Treatment in Chinese Coronary Artery Disease Patients Undergoing PCI
Status: COMPLETED
Conditions: Non-ST Segment Elevation Myocardial Infarction|Unstable Angina Pectoris|Stable Angina Pectoris
Interventions: DRUG: Atorvastatin|DRUG: Statin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial on Early Induction Versus Expectant Management of Nulliparous Women With a Prolonged Latent Phase
Status: COMPLETED
Conditions: Nulliparous Women With Prolonged Latent Phase
Interventions: OTHER: Early induction|OTHER: Expectant mamagement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial in Locally Advanced and Metastatic Adrenocortical Carcinoma Treatment (FIRM-ACT)
Status: COMPLETED
Conditions: Carcinoma, Adrenal Cortical
Interventions: DRUG: Etoposide|DRUG: Doxorubicin|DRUG: Cisplatin|DRUG: Streptozotocin|DRUG: Mitotane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Leaving Care - a Comparison Study of Implementation, Change Mechanisms, and Effects of Transition Services for Youth Leaving Out-of-home Care
Status: RECRUITING
Conditions: Self Efficacy|Mental Health Wellness 1|Help-Seeking Behavior|Frustration|Satisfaction|Health Behavior
Interventions: BEHAVIORAL: My Choice - My Way!|BEHAVIORAL: Usual services
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy, Safety and Tolerability of E2007 in Levodopa Treated Parkinson's Disease Patients With Motor Fluctuations
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: E2007
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Increasing Social Connection Through Crisis Caring Contacts: A Pragmatic Trial
Status: RECRUITING
Conditions: Loneliness
Interventions: BEHAVIORAL: Crisis Caring Contacts post cards|BEHAVIORAL: Control post cards
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Accelerometers for Measuring Daily Activity in Sarcoid
Status: UNKNOWN
Conditions: Sarcoidosis
Interventions: DEVICE: GENEActiv Original Accelerometer|DEVICE: ActiGraph GT3X Accelerometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Vestibular Intervention Via Portable Electrical Stimulator (VIPES)
Status: COMPLETED
Conditions: Balance Disorder
Interventions: DEVICE: Vestibular Intervention via Portable Electrical Stimulator (VIPES) system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Repetitive Transcranial Magnetic Stimulation for Musculoskeletal Pain in Patients With Parkinson's Disease
Status: NOT_YET_RECRUITING
Conditions: Parkinson's Disease|Musculoskeletal Pain|Repetitive Transcranial Magnetic Stimulation|Primary Motor Cortex|Electroencephalography|Neuromodulation
Interventions: PROCEDURE: active M1-rTMS|PROCEDURE: sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacity of Weekly Paclitaxel in Association or Not With Bevacizumab in Metastatic or Locally Advanced Angiosarcomas
Status: COMPLETED
Conditions: Angiosarcoma
Interventions: DRUG: Paclitaxel|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of Modified Vaccinia Virus Ankara (MVA-B) in Healthy Volunteers at Low Risk of HIV Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: MVA-B|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Semi-occluded Vocal Tract Therapy on the Phonation of Children With Vocal Fold Nodules
Status: COMPLETED
Conditions: Voice Disorders in Children|Vocal Nodules in Children|Hoarseness|Dysphonia
Interventions: BEHAVIORAL: Straw phonation|BEHAVIORAL: Resonant voice therapy|BEHAVIORAL: Vocal Hygiene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR) as an Inflammatory Markers to Predict Length of Hospital Stay After Total Laparoscopic Hysterectomy (TLH) for Benign Indications
Status: COMPLETED
Conditions: Inflammation|Hospital Stay|Total Laparoscopic Hysterectomy
Interventions: OTHER: hemogram inflammatory parameters
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Phosphodiesterase-type 5 Inhibitors in Patients With Univentricular Congenital Heart Disease
Status: WITHDRAWN
Conditions: Single-ventricle|Pulmonary Hypertension|Univentricular Heart
Interventions: DRUG: Sildenafil|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: A Pilot and Feasibility Study
Status: COMPLETED
Conditions: Brain Injuries|Wounds and Injuries|Hemorrhage
Interventions: DRUG: Tranexamic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Expanding First-line Options for Depression and Matching Treatments to Patients: Hatha Yoga vs. Behavioral Therapy
Status: RECRUITING
Conditions: Depression
Interventions: OTHER: Online- Yoga-based Intervetion|BEHAVIORAL: Online- BA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Novel Echocardiographic Biomarkers Assessing the Myocardial Work in Heart Failure
Status: RECRUITING
Conditions: Cardiovascular Diseases|Heart Failure|Valvular Heart Disease|Biochemical Dysfunction
Interventions: DIAGNOSTIC_TEST: Investigation of clinical profile, laboratory and novel echocardiographic imaging biomarkers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: e-COGRAT: A Blended eHealth Intervention for Fatigue Following Acquired Brain Injury
Status: NOT_YET_RECRUITING
Conditions: Acquired Brain Injury|Fatigue
Interventions: BEHAVIORAL: e-COGRAT (a blended eHealth intervention)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Soft Tissue Outcomes of Badly Broken-down Teeth Treated With Surgical Extrusion Compared With Immediate Implant Placement
Status: UNKNOWN
Conditions: Broken Teeth
Interventions: PROCEDURE: Surgical Extrusion|PROCEDURE: Immediate Implant Placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Trial to Determine the Effective N-acetylcysteine Dose for Opioid Reduction for Spine Surgery.
Status: COMPLETED
Conditions: Surgery
Interventions: DRUG: Dose Response Curve Placebo|DRUG: Dose Response Curve N-acetylcysteine 50 mg/kg|DRUG: Dose Response Curve N-acetylcysteine 100 mg/kg|DRUG: Dose Response Curve N-acetylcysteine 150 mg/kg|DRUG: Opioid Reduction with Optimal N-acetylcysteine Dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Psychosocial Treatment of Interstitial Cystitis/Bladder Pain Syndrome
Status: COMPLETED
Conditions: Chronic Interstitial Cystitis|Bladder Pain Syndrome|Cystitis, Interstitial|Painful Bladder Syndrome|Cystitis, Chronic Interstitial|Interstitial Cystitis|Interstitial Cystitis, Chronic|Interstitial Cystitis (Chronic) With Hematuria|Interstitial Cystitis (Chronic) Without Hematuria|Chronic Prostatitis|Chronic Prostatitis With Chronic Pelvic Pain Syndrome
Interventions: BEHAVIORAL: Psychosocial Treatment|BEHAVIORAL: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid and Thromboelastography During Cesarean Delivery
Status: TERMINATED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Tranexamic Acid|DRUG: Placebo; Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CryoSpray Ablation(TM)to Determine Safety and Feasibility in Radiation Induced Proctitis
Status: WITHDRAWN
Conditions: Radiation Proctitis|Radiation Induced Proctitis
Interventions: DEVICE: Cryo Spray Ablation Group 1|DEVICE: Cryo Spray Ablation Group 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjutant Apalutamide Plus ADT in Post-RP Patients With High Risk of Recurrence (ARES Study)
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer|Biochemical Recurrence|High Risk
Interventions: DRUG: Apalutamide 60mg Tab|DRUG: Androgen deprivation therapy(ADT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Envofolimab and Lenvatinib Combined With Gemcitabine Plus Cisplatin for Advanced BTC as First-Line Treatment(ENLIGHTEN)
Status: RECRUITING
Conditions: Advanced Biliary Tract Cancer
Interventions: DRUG: Envofolimab|DRUG: Lenvatinib|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Talazoparib + Enzalutamide vs. Enzalutamide Monotherapy in mCRPC
Status: ACTIVE_NOT_RECRUITING
Conditions: mCRPC
Interventions: DRUG: Talazoparib with enzalutamide|DRUG: Placebo with enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Efficacy of A197 in Subjects With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: A197 Ophthalmic Solution|DRUG: A197 Vehicle Control|DRUG: Active Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Tolerance and Acceptability of a Coated Condom
Status: COMPLETED
Conditions: Tolerance and Acceptability of a New Condom Coating
Interventions: DEVICE: Test condom with new Xanthan gum condom coating
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Toxicological Screening by GC-MS Among Children Admitted for a First Afebrile Seizure
Status: COMPLETED
Conditions: Afebrile Seizure (Finding)
Interventions: OTHER: Collection of blood and urine samples|OTHER: Clinical examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Evaluate Long-Term Safety and Efficacy WC3011 (Estradiol Vaginal Cream)
Status: COMPLETED
Conditions: Vulvovaginal Atrophy
Interventions: DRUG: WC3011 Estradiol Vaginal Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetic Bead Tracking System and eOPRA Implant System With Bionic Prosthesis for Transtibial Amputees
Status: NOT_YET_RECRUITING
Conditions: Amputation
Interventions: DEVICE: eOPRA Implant System for Transtibial Amputees and Magnetic Bead Tracking System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Clinical and Basic Research on the Treatment of Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Zishen Qingre Lishi Huayu Granules|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes
Status: UNKNOWN
Conditions: Smoking Cessation|Harm Reduction|E-Cig Use|Cigarette Smoking|Tobacco Dependence|Tobacco Use Cessation
Interventions: OTHER: JUUL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glutaminase Inhibition and Chemoradiation in Advanced Cervical Cancer
Status: NOT_YET_RECRUITING
Conditions: Advanced Cervical Carcinoma|Cervical Cancer|Cervix Cancer|Cancer of the Cervix
Interventions: DRUG: Telaglenastat|RADIATION: Radiation treatment|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ondansetron in Treatment Resistant Obsessive Compulsive Disorder (OCD)
Status: COMPLETED
Conditions: Obsessive Compulsive Disorder
Interventions: DRUG: ondansetron
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Aquatic Theraphy in Spasticity: Watsu and Halliwick
Status: UNKNOWN
Conditions: Brain-injury
Interventions: OTHER: Experimental group:Halliwick + Método Watsu|OTHER: Control group:Halliwick
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ibuprofen Plus Metaxolone, Tizanidine, or Baclofen for Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: Metaxalone|DRUG: Tizanidine|DRUG: Baclofen|DRUG: Ibuprofen 600 mg|BEHAVIORAL: Educational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Live, Attenuated Influenza Vaccination in Preterm and Full-Term Infants
Status: TERMINATED
Conditions: Influenza
Interventions: BIOLOGICAL: Live attenuated influenza vaccine|BIOLOGICAL: Inactivated influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Reverse Barrel™ VRD Intracranial Aneurysm Trial
Status: COMPLETED
Conditions: Intracranial Aneurysms
Interventions: DEVICE: Barrel™ Vascular Reconstruction Device (VRD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of IHHT on Vascular Stiffness and Elasticity of the Liver Tissue in Patients With MS.
Status: COMPLETED
Conditions: Vascular Stiffness|Liver Fibroses|Metabolic Syndrome|Trimethylamine N-oxyde|Toll-like Receptors
Interventions: PROCEDURE: Interval hypoxic-hyperoxic training (IHHT) using respiratory therapy unit ReOxy.|PROCEDURE: Simulating Interval hypoxic-hyperoxic training (IHHT) using respiratory therapy unit ReOxy.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Anti-GD2 CAR T Cells in Pediatric Patients Affected by High Risk and/or Relapsed/Refractory Neuroblastoma or Other GD2-positive Solid Tumors
Status: RECRUITING
Conditions: Neuroblastoma|Neuroblastoma Recurrent|GD2-positive Solid Tumors|Osteosarcoma|Ewing Sarcoma|Sarcoma
Interventions: BIOLOGICAL: GD2-CART01
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Pharmacopuncture Therapy for Patients With Lumbar Spinal Stenosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Lumbar Spinal Stenosis
Interventions: PROCEDURE: pharmacopuncture|PROCEDURE: conservative treatments (including physiotherapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Resilience and Modification of Brain Control Network Following November 13
Status: UNKNOWN
Conditions: Post-Traumatic Stress Disorder
Interventions: BEHAVIORAL: Psychopathological assessment|BEHAVIORAL: Neuropsychological assessment|DEVICE: Functional magnetic resonance imaging (fMRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Unstable Dorsally Displaced Fractures of the Distal Radius in the Elderly
Status: UNKNOWN
Conditions: Fracture of the Distal Radius|Wrist Fracture
Interventions: PROCEDURE: open reduction and internal fixation with a volar plate|PROCEDURE: closed reduction and plaster treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the WATCHMAN™ Device in Patients Unsuitable for Oral Anticoagulation
Status: ACTIVE_NOT_RECRUITING
Conditions: Stroke
Interventions: DEVICE: WATCHMAN LAAC Device Implant|DRUG: Single Antiplatelet Therapy or No Therapy (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Use of Triamcinolone Injection in Treatment of Refractory Benign Esophageal Stricture in Children
Status: UNKNOWN
Conditions: Esophageal Stricture
Interventions: DRUG: Triamcinolone Injection in treatment of refractory benign Esophageal Stricture in children
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety Study Of Inhaled Insulin (CP-464,005, Inhaler) In Japanese Patients With Type1 or Type2 Diabetes
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2|Diabetes Mellitus, Type 1
Interventions: DRUG: CP-464,005|DRUG: CP-464,005|DRUG: CP-464,005
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propess Versus Prostin for Induction of Labour in Women With Term PROM
Status: UNKNOWN
Conditions: Premature Rupture of Membranes at Term|Induction of Labour
Interventions: DRUG: Prostaglandin E2 (Propess)|DRUG: Prostaglandin E2 (Prostin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety And Efficacy Study Of Topic Mucopolysaccharide Polysulfate In The Superficial Varicose Veins Treatment
Status: WITHDRAWN
Conditions: VARICOSE VEINS
Interventions: DRUG: TOPIC MUCOPOLYSACCHARIDE POLYSULFATE 5MG/G
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Noncarious Cervical Lesion Treatment Outcomes
Status: COMPLETED
Conditions: Noncarious Cervical Lesions
Interventions: OTHER: Chemoactive (remineralizing, neuroactive) dentifrice treatment|OTHER: Clearfil S3 Bond; Clearfil Liner Bond 2 Protect Liner F|OTHER: Clearfil S3 Bond; Premise Flowable resin-based composite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double Blind Crossover Comparison of Diuretics in the Young
Status: UNKNOWN
Conditions: Low-Renin Hypertension
Interventions: DRUG: Bendroflumethiazide 2.5mg - 5mg|DRUG: Amiloride 20-40mg|DRUG: Spironolactone 50-100mg|DRUG: Frusemide 20-40mg|DRUG: Bendroflumethiazide 1.25-2.5mg/ Amiloride 10-20mg combined
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Intravenous Vitamin C Combined With Nerve Blocks on Postoperative Pain and Recovery After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Ascorbic Acid|Postoperative Pain
Interventions: DRUG: Ascorbic acid 5000mg|DRUG: Control Rx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1|Adult Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A|Adult Acute Promyelocytic Leukemia With PML-RARA|Alkylating Agent-Related Acute Myeloid Leukemia|Chronic Myelomonocytic Leukemia|Myelodysplastic Syndrome|Previously Treated Myelodysplastic Syndrome|Recurrent Adult Acute Myeloid Leukemia
Interventions: DRUG: Erlotinib Hydrochloride|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-dose Dexmedetomidine in Mechanically Ventilated ICU Patients
Status: SUSPENDED
Conditions: Adult Disease|Intensive Care Unit Syndrome|Mechanical Ventilation Complication|Delirium|Dexmedetomidine
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo (normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rapid Cortisol Assay in Adrenal Vein Sampling
Status: UNKNOWN
Conditions: Primary Aldosteronism Due to Aldosterone Producing Adenoma
Interventions: PROCEDURE: AVS performed with no intraprocedural rapid cortisol assay|PROCEDURE: AVS performed plus intraprocedural rapid cortisol assay
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Assess In-home Use of Evolocumab (AMG 145) Using a Prefilled Syringe or a Prefilled Autoinjector/Pen
Status: COMPLETED
Conditions: Primary Hypercholesterolemia|Mixed Dyslipidemia
Interventions: BIOLOGICAL: Evolocumab Pre-filled Syringe|BIOLOGICAL: Evolocumab AI/pen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Efficacy and Safety of Mosunetuzumab in Combination With Lenalidomide in Comparison to Rituximab in Combination With Lenalidomide With a US Extension of Mosunetuzumab in Combination With Lenalidomide in Participants With Follicular Lymphoma
Status: RECRUITING
Conditions: Relapsed or Refractory Follicular Lymphoma
Interventions: DRUG: Mosunetuzumab|DRUG: Lenalidomide|DRUG: Rituximab|DRUG: Tociluzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid De-escalation of Anti-MRSA Therapy Guided by S. Aureus Nares Screening in Case of Pneumonia
Status: NOT_YET_RECRUITING
Conditions: Pneumonia, Bacterial
Interventions: DIAGNOSTIC_TEST: MRSA nasal swab based de-escalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Sedation on Spinal Anesthesia-induced Maternal Hypotension
Status: COMPLETED
Conditions: Cesarean Section|Preoperative Anxiety|Spinal Anesthesia|Sedation|Maternal Hypotension
Interventions: DRUG: Sedation|DRUG: No sedation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Immunogenicity Study of GX-19N, a COVID-19 Preventive DNA Vaccine in Healthy Adults
Status: UNKNOWN
Conditions: SARS-CoV-2
Interventions: DRUG: GX-19N|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Using Big Data to Conduct Innovative Cardiovascular Clinical Trials
Status: RECRUITING
Conditions: Cardiovascular Diseases|Cardiovascular Risk Factor|Dyslipidemias
Interventions: OTHER: Lipid management toolbox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Cocoa Flavanol on Skin Aging
Status: COMPLETED
Conditions: Ageing|Photo-aging
Interventions: DIETARY_SUPPLEMENT: Cocoa flavanol beverage|DIETARY_SUPPLEMENT: Placebo beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About the Effects of Sisunatovir in Infants With Respiratory Syncytial Virus Lower Respiratory Tract Infection.
Status: TERMINATED
Conditions: Respiratory Syncytial Virus (RSV)|Lower Resp Tract Infection
Interventions: DRUG: RV521|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Economic Evaluation of the MEWE Intervention
Status: COMPLETED
Conditions: Depression|Mental Health Issue|Intimate Partner Violence|Domestic Violence|Gender-based Violence|Rape Sexual Assault|Battered Women
Interventions: BEHAVIORAL: Life Skills Building (LSB) curriculum for males|BEHAVIORAL: Life Skills Building (LSB) curriculum for females|OTHER: Cash transfer to adult females
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Enhancing Prospective Thinking in Early Recovery (PARK)
Status: RECRUITING
Conditions: Opioid Use|Opioid Use Disorder|Substance Use Disorders
Interventions: DEVICE: Virtual Reality Avatar Intervention|DEVICE: Virtual Reality Empty Park
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Investigation of Biofilm Formation on Temporary push-on Rings of Implant Crowns
Status: RECRUITING
Conditions: Dental Plaque|Oral Biofilm|Peri-implantitis
Interventions: DEVICE: Rings made of PA (test)|DEVICE: Rings made of TAN (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC