pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Early Detection of Multiple Myeloma to Fight Cancer Disparities: A Screening and Patient Navigation Program
Status: RECRUITING
Conditions: Multiple Myeloma|Monoclonal Gammopathy of Undetermined Significance|Smoldering Multiple Myeloma
Interventions: OTHER: Multiple Myeloma M-Protein Analysis|OTHER: Multiple Myeloma Knowledge Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Hyperpolarized 13C MRI for Cancer Immunotherapy
Status: NOT_YET_RECRUITING
Conditions: Gynecologic Cancer|Cervical Cancer|Endometrial Cancer|Ovarian Cancer
Interventions: DRUG: Hyperpolarized 13C-Pyruvate injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Trial of Air Cleaners to Improve Indoor Air Quality and COPD Health
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DEVICE: HEPA Air Cleaner|DEVICE: Sham HEPA Air Cleaner
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Trial of GSK1120212 and GSK1120212 in Combination With GEM in Japanese Subjects With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumours
Interventions: DRUG: GSK1120212|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extension Study of the Safety and Anti-leukemic Effects of Imatinib Mesylate in Participants With Philadelphia Chromosome-positive Chronic Myeloid Leukemia in Blast Crisis
Status: COMPLETED
Conditions: Philadelphia Chromosome Positive CML
Interventions: DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Tulsi Extract for The Management of Oral Mucositis in Head & Neck Cancer Patients Undergoing Radiotherapy
Status: UNKNOWN
Conditions: Stomatitis
Interventions: DRUG: tulsi extract|DRUG: Benzydamine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TMC114-TiDP3-C176 - A Study in Healthy Volunteers Investigating the Bioequivalence Between Two Commercially Available 400-mg Tablets to One New 800-mg Tablet of Darunavir (DRV) in the Presence of Low-dose Ritonavir Under Fed and Fasted Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Darunavir (DRV)|DRUG: ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ibuprofen Chronotherapy in Healing After Surgical Extraction of the Mandibular Third Molar
Status: UNKNOWN
Conditions: Operation Site Inflammation|Pain, Postoperative|Teeth, Impacted
Interventions: DRUG: Ibuprofen 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Walking and Respiratory Muscle Training on Pulmonary Function and Functional Exercise Capacity in PD
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: Walking and respiratory training|OTHER: Respiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Electroacupuncture on Clinical Effect,Brain Structural and Functional Changes on Spinal Cord Injury
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: OTHER: Electroacupuncture+Routine rehabilitation training Group|BEHAVIORAL: Routine rehabilitation training Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Safe: Consumer Intervention to Reduce Exposure to Drugs Linked to Alzheimer's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer Disease|Dementia
Interventions: OTHER: Brain Safe App|OTHER: Attention Control App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bovine Lactoferrin and Neonatal Survival in Low Birth Weight Babies.
Status: UNKNOWN
Conditions: Neonatal Sepsis|Necrotizing Enterocolitis
Interventions: COMBINATION_PRODUCT: bLF (Bovine lactoferrin)|DRUG: Glucon-D 99.4% (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Australian Placental Transfusion Study (APTS): Should Very Pre Term Babies Receive a Placental Blood Transfusion at Birth Via Deferring Cord Clamping Versus Standard Cord Clamping Procedures?
Status: COMPLETED
Conditions: Preterm Birth
Interventions: PROCEDURE: Deferred cord clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Behavioral Approaches to Reducing Diabetes Distress and Improving Glycemic Control
Status: COMPLETED
Conditions: Type 1 Diabetes|Diabetes Distress
Interventions: BEHAVIORAL: StreamLine|BEHAVIORAL: TunedIn|BEHAVIORAL: FixIt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence
Status: COMPLETED
Conditions: Nicotine Dependence|Nicotine Withdrawal
Interventions: DRUG: Bupropion|DRUG: Varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Deep Learning Algorithms for Prediction of Lymph Node Metastasis and Prognosis in Breast Cancer MRI Radiomics (RBC-01)
Status: RECRUITING
Conditions: Breast Neoplasm Female|Early-stage Breast Cancer|Radiomics|Axillary Lymph Node|Survival, Prosthesis
Interventions: OTHER: No interventions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Role of Nefopam in Rituximab Transfusion Reaction
Status: NOT_YET_RECRUITING
Conditions: Nefopam
Interventions: DRUG: Nefopam ampule|DRUG: diphenhydramine ampule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker
Status: UNKNOWN
Conditions: Arthritis, Rheumatoid|Spondylitis, Ankylosing
Interventions: DRUG: TNF blockers (infliximab, adalimumab, etanercept)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Evaluate Analgesic / Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Naproxen Sodium 440 mg / DPH 25 mg (BAY98-7111)|DRUG: Naproxen Sodium 440 mg (BAYH6689)|DRUG: DPH 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Cognitive-behavioral Education and Exercise Interventions on Smoking Cessation
Status: UNKNOWN
Conditions: Coronary Artery Disease|Smoking Cessation
Interventions: BEHAVIORAL: cognitive-behavioral education|BEHAVIORAL: 12-week brisk walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: NRX-1074 in Early Course Schizophrenia
Status: WITHDRAWN
Conditions: Schizophrenia
Interventions: DRUG: NRX-1074|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Water Exchange Colonoscopy With Artificial Intelligence-assisted Detection
Status: RECRUITING
Conditions: Colon Adenoma|Colonoscopy|Colon Polyp
Interventions: DEVICE: Water exchange alone|DEVICE: Water exchange plus Artificial Intelligence (AI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: A One-year Safety Study of Flibanserin to Treat Pre-Menopausal Women With Hypoactive Sexual Desire Disorder (HSDD).
Status: TERMINATED
Conditions: Sexual Dysfunctions, Psychological
Interventions: DRUG: Flibanserin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Docosahexaenoic Acid Supplementation on Microbiome in Obese ChiLdrEn.
Status: UNKNOWN
Conditions: Childhood Obesity
Interventions: DRUG: Docosahexaenoic Acid Supplementation|OTHER: Promotion of physical activity|OTHER: Promotion of healthy food habits
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identifying the Predictive Factors of Response to PD-1 or PD-L1 Antagonists
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma|Non Small Cell Lung Cancer|Head and Neck Squamous Cell Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biopsy|PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Reduced Nicotine Cigarettes in Smokers With Mood and Anxiety Disorders
Status: COMPLETED
Conditions: Tobacco Dependence
Interventions: DRUG: Reduced Nicotine Content Cigarettes|DRUG: Usual Nicotine Content Cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Lactoferrin in Treatment of Fe Deficient Anemia In Cirrhosis
Status: RECRUITING
Conditions: Iron Deficiency Anemia|Chronic Liver Failure
Interventions: DRUG: Lactoferrin + Iron Supplement|DRUG: Iron Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study of Zolbetuximab (IMAB362) in Chinese Subjects With Locally Advanced Unresectable or Metastatic Gastric or Gastro-esophageal Junction (GEJ) Adenocarcinoma
Status: COMPLETED
Conditions: Gastric or Gastro-esophageal Junction (GEJ) Adenocarcinoma
Interventions: DRUG: zolbetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Marrow Transplant Using a Reduced Intensity Regimen That is Given in Two Steps
Status: TERMINATED
Conditions: Hematologic Malignancies|Acute Leukemia|Myelodysplastic Syndromes (MDS) Other Than RA or RARS Subtypes|Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma|Myeloma|Chronic Myelogenous (or Myeloid) Leukemia (CML) Resistant to STI Therapy
Interventions: DRUG: Fludarabine|DRUG: Thiotepa|RADIATION: Total Body Irradiation (TBI)|BIOLOGICAL: Donor Lymphocyte Infusion (DLI)|DRUG: Melphalan|DEVICE: Hematopoietic stem cell transplantation (HSCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Inflammatory Biomarkers Expressed in a Sjogren's Population: Effect of a Topical Steroid Intervention
Status: COMPLETED
Conditions: Sjogren's Syndrome
Interventions: DRUG: Maxidex|OTHER: No treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Vedolizumab Intravenous (IV) in the Treatment of Primary Sclerosing Cholangitis in Subjects With Underlying Inflammatory Bowel Disease
Status: WITHDRAWN
Conditions: Primary Sclerosing Cholangitis|Inflammatory Bowel Disease
Interventions: DRUG: Vedolizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Metastatic Pancreatic Cancer That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: cisplatin|DRUG: fluorouracil|DRUG: gemcitabine hydrochloride|DRUG: leucovorin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Violet-Blue Light Inactivation of Bacteria in Chronic Wounds
Status: COMPLETED
Conditions: Phototherapy Complication|Photobiology|Light Treatment; Complications|Wound Infection|Wound Heal
Interventions: DEVICE: Violet-Blue Light Treatment / FlashHeal Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Study of Concurrent Chemotherapy and Radiotherapy for Stage II Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: cisplatin|RADIATION: 3D-CRT (three-dimensional conformal radiation therapy) or IMRT (intensity-modulated radiation therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Tablets of Silybum Marianum, Pueraria Lobate and Salvia Miltiorrhiza on Fatty Liver
Status: UNKNOWN
Conditions: Fatty Liver Disease
Interventions: DIETARY_SUPPLEMENT: Tablet of silybum marianum, Pueraria lobate and salvia miltiorrhiza|OTHER: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Optimize Growth Hormone Dosing in Children With Chronic Kidney Disease by Measuring IGF-1 Levels in Blood
Status: COMPLETED
Conditions: Kidney Failure, Chronic|Growth Hormone Deficiency
Interventions: DRUG: Nutropin AQ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 1b Study With Volociximab in Combination With Carboplatin and Paclitaxel in First-line, Advanced Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: M200 (Volociximab), Carboplatin, Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clarithromycin Mechanisms in Hypersomnia Syndromes
Status: RECRUITING
Conditions: Narcolepsy Without Cataplexy|Idiopathic Hypersomnia|Narcolepsy With Cataplexy
Interventions: DRUG: Clarithromycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Project for Cognitive Advancement in Infants With Neuromotor Disorders
Status: COMPLETED
Conditions: Motor Coordination or Function; Developmental Disorder
Interventions: BEHAVIORAL: Motor + problem solving|BEHAVIORAL: body weight support training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study of ACE-031 in Subjects With Duchenne Muscular Dystrophy
Status: TERMINATED
Conditions: Duchenne Muscular Dystrophy
Interventions: BIOLOGICAL: ACE-031 (Extension of cohort 1 from core study, A031-03)|BIOLOGICAL: ACE-031 (Extension of cohort 2 from core study, A031-03)|BIOLOGICAL: ACE-031 (Extension of cohort 3 from core study, A031-03)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Barbed Versus Conventional Sutures for Vaginal Cuff Closure During Total Laparoscopic Hysterectomy
Status: UNKNOWN
Conditions: Hysterectomy
Interventions: DEVICE: Vaginal cuff closure using barbed sutures|DEVICE: Vaginal cuff closure using conventional sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Quality of Supraclavicular, Infraclavicular and Axillary Approach of Ultrasound-guided Brachial Plexus Block
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Sofosbuvir + Ribavirin in Adolescents and Children With Genotype 2 or 3 Chronic HCV Infection
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: SOF|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-time Feedback of SYNTAX Score Category During Coronary Angiographies to Improve Appropriateness of Coronary Revascularization for Patients With Stable Coronary Artery Diseases: a Before-and-after Controlled Study
Status: COMPLETED
Conditions: Syntax Score|Appropriateness|Coronary Revascularization
Interventions: DIAGNOSTIC_TEST: real-time feedback of SYNTAX score category
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed Disodium in Treating Patients With Stage IV Non-small Cell Lung Cancer and ECOG Performance Status 3
Status: COMPLETED
Conditions: Stage IV Non-Small Cell Lung Cancer
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Pemetrexed Disodium|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strategies for Toddler ASD With Remote-therapy (STAR) Model for ASD
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Therapy
Interventions: BEHAVIORAL: Strategies for Toddler ASD with Remote-therapy (STAR)|BEHAVIORAL: Community intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Polypropylene Mesh and "Small Bites" Technique in Emergency Colorectal Surgery's Midline Laparotomy Closure. Study for Incisional Hernia Prevention.
Status: RECRUITING
Conditions: Colorectal Cancer|Incisional Hernia|Wound Infection
Interventions: PROCEDURE: Closure of the midline laparotomy using the "small bites" technique|PROCEDURE: Closure of the midline laparotomy using the "small bites" technique with an absorbable PP mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thymectomy With and Without Povidone-iodine Pleural Lavage in Stage IVA Thymic Malignancies
Status: WITHDRAWN
Conditions: Stage IVA Thymoma
Interventions: DRUG: Intraoperative providone-iodine lavage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fractional Exhaled Nitric Oxide (FeNO)- Test as add-on Test in the Diagnostic Work-up of Asthma
Status: RECRUITING
Conditions: Diagnosis|Asthma
Interventions: DIAGNOSTIC_TEST: FeNO-test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Immunological Disorders of T Lymphocytes and Endocrinological Disorders as Pathogen Factors in Patients With Metaplasia of Urinary Bladder
Status: COMPLETED
Conditions: The Follow-up Duration Was 1-8 Years.|The Main Reasons Behind Visiting the Hospital Were Recurrent Urinary Tract Infection,|Urinary Urgencies, Pollakiuria, Difficulty in Initiating Micturition, Pain in Hypogastrium,|Night Wetting and Day Wetting, Menstruation's Disorders, Urolithiasis, Defects of Urinary|System and Hematuria.
Interventions: DRUG: Second-generation cephalosporin, nitrofurantoin, 1% aminoglycoside solution|DRUG: cephalosporin with chemotherapeutics
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Baricitinib in Patients With Moderate and Severe COVID-19
Status: UNKNOWN
Conditions: Covid19
Interventions: DRUG: Baricitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Paracetamol Versus Oral Ibuprofen in Management of Patent Ductus Arteriosus in Preterm Infants: A Randomised Controlled Trial
Status: COMPLETED
Conditions: Patent Ductus Arteriosus
Interventions: DRUG: Oral paracetamol|DRUG: Oral ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Rehabilitation of Operations Iraqi Freedom and Enduring Freedom (OIF/OEF) Veterans With Cognitive Disorder
Status: COMPLETED
Conditions: Cognition Disorders
Interventions: BEHAVIORAL: Cognitive Strategy Training|OTHER: Placebo comparison group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I and Pharmacokinetic Study of Biweekly PEP02 in mCRC Refractory to 1st-line Oxaliplatin Base Therapy
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: PEP02
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Plasma Caffeine Concentration After Oral Consumption of Caffeinated Beverages With Varied Bioactive Compounds in Healthy Volunteers
Status: COMPLETED
Conditions: Plasma Caffeine Concentration
Interventions: OTHER: Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Early Phase I Study of Autologous T Cells (EX02 CAR-T) for Unresectable Pancreatic/Bile Duct Cancer
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Cancer|Advanced Biliary Cancer
Interventions: DRUG: anti-EX02 CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Clevudine Compared With Adefovir in Patients With Chronic Hepatitis Due to Hepatitis B Virus
Status: TERMINATED
Conditions: Chronic Hepatitis|Hepatitis B
Interventions: DRUG: Clevudine|DRUG: Adefovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Dietary Intervention Program for Pre-eclampsia in Women at Risk
Status: UNKNOWN
Conditions: Pre-eclampsia
Interventions: DIETARY_SUPPLEMENT: 1500 mg Calcium and 1200 IU Vitamin D for 2 months|BEHAVIORAL: balanced diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Safety, Efficacy, and Pharmacokinetics of Intravenous Deferiprone in HIV-Positive Subjects
Status: COMPLETED
Conditions: Asymptomatic HIV Infection
Interventions: DRUG: Intravenous deferiprone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Liposomal Bupivacaine Redosing in Patients Undergoing Major Gynecologic Procedures
Status: TERMINATED
Conditions: Ovarian Cancer|Fibroids|Uterine Cancer
Interventions: DRUG: Bupivacaine|DRUG: Liposomal bupivacaine|DRUG: Liposomal bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Investigating the nCAP Signal Relief Patch in Subjects Undergoing Primary Hip or Knee Replacement Surgery
Status: COMPLETED
Conditions: Opioid Use|Pain, Post Operative
Interventions: DEVICE: nCAP Signal Relief Patch|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative CCRT With Docetaxel vs Cisplatin in High Risk Oral Cavity Cancer
Status: COMPLETED
Conditions: Oral Cavity Squamous Cell Carcinoma
Interventions: DRUG: Docetaxel|DRUG: Cisplatin|RADIATION: IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Invega (Paliperidone) for the Treatment of Mania in Children and Adolescents Ages 6-17 With Bipolar Disorder
Status: TERMINATED
Conditions: Pediatric Bipolar Disorder
Interventions: DRUG: paliperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quaternary Ammonium Methacryloxy Silicate-containing Acrylic Resin
Status: COMPLETED
Conditions: Oral Health
Interventions: DEVICE: QAMS-containing PMMA|DEVICE: QAMS-free PMMA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability, and Pharmacokinetics of SAB-185 in Healthy Participants
Status: COMPLETED
Conditions: COVID-19|SARS-CoV2
Interventions: BIOLOGICAL: SAB-185|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of 8-week Continuous Treatment With Polyethylene Glycol Loxenatide in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: PEX168
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Triple Therapy in Patients With Idiopathic Thrombocytopenic Purpura : What is Behind?
Status: UNKNOWN
Conditions: Idiopathic Thrombocytopenic Purpura
Interventions: DIAGNOSTIC_TEST: Serological assay for blood born viral hepatitis|DIAGNOSTIC_TEST: Quantitative microbiological test for HCV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Immunogenicity and Safety of Fractional Doses of IPV Intradermally vs Full Doses Intramuscularly
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: Inactivated Poliomyelitis vaccine (IMOVAX)|BIOLOGICAL: Inactivated Poliomyelitis vaccine (IMOVAX)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy in Treating Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
Status: UNKNOWN
Conditions: Leukemia
Interventions: DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: etoposide phosphate|DRUG: hydrocortisone sodium succinate|DRUG: imatinib mesylate|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: methylprednisolone|DRUG: pegaspargase|DRUG: prednisolone|DRUG: prednisone|DRUG: vincristine sulfate|OTHER: laboratory biomarker analysis|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Naltrexone for Heavy Drinking in Young Adults
Status: COMPLETED
Conditions: Alcohol Consumption|Alcoholic Intoxication|Alcoholism|Alcohol-induced Disorders
Interventions: BEHAVIORAL: BASICS counseling|DRUG: naltrexone|DRUG: placebo naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Comparison of 2 Multifocal Toric XR (Extended Range) Contact Lenses
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: comfilcon A|DEVICE: omafilcon B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: CART22 Alone or in Combination With huCART19 for ALL
Status: ACTIVE_NOT_RECRUITING
Conditions: Chemotherapy Resistant Acute Lymphoblastic Leukemia|Refractory Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: CART22-65s cells|BIOLOGICAL: huCART19 Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Bias Modification (CBM) and Internet Cognitive Behavioural Therapy (iCBT) for Depression- A Randomised Controlled Trial
Status: COMPLETED
Conditions: Depression
Interventions: OTHER: OxIGen + iCBT|OTHER: Waitlist Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-Dose Moderna mRNA-1273 Booster Study for Lung Transplant Recipients
Status: COMPLETED
Conditions: Lung Transplant Recipient|SARS-CoV-2|Immunosuppression
Interventions: DRUG: mRNA-1273 (Moderna COVID-19 vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prevention of Events With Angiotensin-Converting Enzyme Inhibitor Therapy (PEACE)
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Disease|Heart Diseases|Myocardial Infarction|Myocardial Ischemia
Interventions: DRUG: angiotensin-converting enzyme inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Aprepitant for the Prevention of Post-Operative Nausea and Vomiting in Children (MK-0869-219)
Status: COMPLETED
Conditions: Post-operative Nausea|Post-operative Vomiting
Interventions: DRUG: Aprepitant|DRUG: Placebo to Aprepitant|DRUG: Ondansetron|DRUG: Placebo to match ondansetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy With Parental Involvement for Treating Children With Anxiety Disorders
Status: COMPLETED
Conditions: Anxiety Disorders
Interventions: BEHAVIORAL: Individual cognitive behavioral therapy (ICBT)|BEHAVIORAL: Parent relationship training (PRT2) With Individual Cognitive Behavioral Therapy (ICBT)|BEHAVIORAL: Parent reinforcement training (PRT1) With Individual Cognitive Behavioral Therapy (ICBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression
Status: ACTIVE_NOT_RECRUITING
Conditions: Depression|Unipolar Depression|Treatment Resistant Depression
Interventions: DEVICE: Magnetic Seizure Therapy|DEVICE: Electroconvulsive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NAM-Trial: Multiferon in Malignant Melanoma
Status: COMPLETED
Conditions: Locoregional Metastases in Malignant Melanoma Stages IIIB/C
Interventions: DRUG: human interferon-α
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study to Compare the Bioavailability of Two Halobetasol Propionate 0.05% Topical Ointments
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Halobetasol Propionate 0.05% Ointment-Reference Product|DRUG: Halobetasol Propionate 0.05% Ointment-Test Product
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Dexamethasone Plus IXAZOMIB (MLN9708) or Physicians Choice of Treatment in Relapsed or Refractory Systemic Light Chain (AL) Amyloidosis
Status: TERMINATED
Conditions: Relapsed or Refractory Systemic Light Chain Amyloidosis
Interventions: DRUG: IXAZOMIB|DRUG: Dexamethasone|DRUG: Melphalan|DRUG: Cyclophosphamide|DRUG: Thalidomide|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: De-escalation and TFR Study in CML Patients Treated With Nilotinib Followed by a Second Attempt After Nilotinib and Asciminib Combination
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Nilotinib|DRUG: Nilotinib|DRUG: Asciminib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3D Maternal Fetal Bonding
Status: COMPLETED
Conditions: Maternal-Fetal Relations|Paternal Behavior|Maternal Behavior
Interventions: OTHER: 3D printed model|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Subcutaneously Injected Epcoritamab Plus Oral Lenalidomide Tablets Compared to Intravenously (IV) Infused Rituximab Plus IV Infused Gemcitabine and IV Infused Oxaliplatin in Adult Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Epcoritamab|DRUG: Rituximab|DRUG: Lenalidomide|DRUG: Oxaliplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Tolerability and Pharmacokinetics of CKD-348(2)
Status: COMPLETED
Conditions: Hypertension and Dyslipidemia
Interventions: DRUG: CKD-348(2)|DRUG: CKD-828, D097, D337
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Orthokeratology for High Myopia (OHM) Study
Status: UNKNOWN
Conditions: Myopia|High Myopia
Interventions: DEVICE: ortho-k lenses and thinner spectacles|DEVICE: newly designed ortho-k lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ARRY-520 in Patients With Advanced Cancer
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: ARRY-520, KSP(Eg5) inhibitor; intravenous|DRUG: Filgrastim, granulocyte-colony stimulating factor (G-CSF); subcutaneous
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1)
Status: ACTIVE_NOT_RECRUITING
Conditions: Tumor|Tumor, Solid|Metastasis|Metastatic Cancer|Cancer|Cancer Metastatic|Tumors|Neoplasms|Neoplasm Metastasis|Solid Tumor|Advanced Solid Tumor|Advanced Cancer|Malignant Solid Tumor|Malignant Solid Neoplasm|Malignant Neoplasm|Malignant Tumor|TSC|TSC1|TSC2|Metastatic Solid Tumor|Metastatic Neoplasm
Interventions: DRUG: nab-sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Abiraterone Acetate in Metastatic Castration-Resistant Prostate Cancer Participants Who Responded Poorly to the First-line Combined Androgen Blockade Therapy
Status: COMPLETED
Conditions: Metastatic Castration-Resistant Prostate Cancer
Interventions: DRUG: Abiraterone Acetate|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spine Stereotactic Body Radiation Therapy for Metastatic Epidural Spinal Cord Compression
Status: UNKNOWN
Conditions: Spinal Cord Compression
Interventions: RADIATION: Stereotactic body radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool
Status: NOT_YET_RECRUITING
Conditions: Liver Transplant
Interventions: DEVICE: Normothermic machine perfusion (NMP) of steatotic liver
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Endoscopic Injection of Conventional and Double Doses Cyanoacrylate for Gastric Variceal Hemorrhage
Status: COMPLETED
Conditions: Gastric Variceal Bleeding
Interventions: PROCEDURE: Cyanoacrylate|PROCEDURE: Cyanoacrylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OStéopontin as a Marker Of StenoSIS - OSMOSIS
Status: COMPLETED
Conditions: Stenosis
Interventions: PROCEDURE: Blood sampling in arterioveinous fistula without stenosis|PROCEDURE: Blood sampling in arterioveinous fistula with stenosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Effects of a One-session Mindfulness of the Breath Meditation Practice on State Hope and State Gratitude in the General Population
Status: COMPLETED
Conditions: Healthy
Interventions: BEHAVIORAL: Mindfulness of the breath meditation|BEHAVIORAL: Audio-recording control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: RIC alloBMT With Post-transplant Cyclophosphamide for Refractory Systemic Sclerosis
Status: RECRUITING
Conditions: Systemic Sclerosis
Interventions: BIOLOGICAL: RIC alloBMT w PTCy in refractory SSc
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation (tDCS) in Chronic Neuropathy
Status: TERMINATED
Conditions: Neuropathic Pain|Neuralgia
Interventions: DEVICE: cathodal transcranial direct current stimulation (tDCS)|DEVICE: sham transcranial direct current stimulation (tDCS)|DEVICE: anodal transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modern Immunotherapy in BCG-Unresponsive, BCG-Relapsing and High Risk BCG-Naive Non-Muscle Invasive Urothelial Carcinoma of the Bladder
Status: RECRUITING
Conditions: Urothelial Carcinoma|Bladder Cancer
Interventions: DRUG: Durvalumab (Cohort 1-3)|RADIATION: External Beam Radiotherapy (EBRT)|BIOLOGICAL: Bacillus Calmette-Guérin (BCG)|DRUG: Gemcitabine|DRUG: Docetaxel|BIOLOGICAL: Tremelimumab|DRUG: Durvalumab (Cohort 4/5)|OTHER: To be determined
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MSG and Gastrointestinal Motility
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DIETARY_SUPPLEMENT: Monosodium glutamate|DIETARY_SUPPLEMENT: Sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dose Finding Study Of PF-05212384 With Paclitaxel And Carboplatin In Patients With Advanced Solid Tumor
Status: COMPLETED
Conditions: Breast Cancer|NSCLC|Ovary Cancer|Endometrial Cancer|Small Cell Lung Cancer (SCLC)|Head and Neck (HNSCC)
Interventions: DRUG: PF-05212384|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Evaluation of mHealth Solutions to Monitor and Involve Cardiometabolic Patients in Self-care
Status: UNKNOWN
Conditions: Hypertension|Diabetes|Heart Failure|Copd|Asthma|Obesity
Interventions: DEVICE: Mobile application
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacological Prophylaxis of Post- Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis
Status: UNKNOWN
Conditions: Post-ERCP Pancreatitis
Interventions: DRUG: indomethacin suppository|DRUG: N-acetylcysteine (NAC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Short-term Effects of an SGLT2 Inhibitor on Divalent Ions in Autosomal Dominant Polycystic Kidney Disease
Status: NOT_YET_RECRUITING
Conditions: Autosomal Dominant Polycystic Kidney Disease
Interventions: DRUG: Empagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Previously Untreated Rhabdomyosarcoma
Status: COMPLETED
Conditions: Adult Malignant Mesenchymoma|Adult Rhabdomyosarcoma|Alveolar Childhood Rhabdomyosarcoma|Childhood Malignant Mesenchymoma|Embryonal Childhood Rhabdomyosarcoma|Embryonal-botryoid Childhood Rhabdomyosarcoma|Nonmetastatic Childhood Soft Tissue Sarcoma|Previously Untreated Childhood Rhabdomyosarcoma|Stage I Adult Soft Tissue Sarcoma|Stage II Adult Soft Tissue Sarcoma|Stage III Adult Soft Tissue Sarcoma
Interventions: BIOLOGICAL: dactinomycin|DRUG: vincristine sulfate|DRUG: cyclophosphamide|PROCEDURE: therapeutic conventional surgery|RADIATION: radiation therapy|DRUG: topotecan hydrochloride|BIOLOGICAL: filgrastim|BIOLOGICAL: sargramostim|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess the Glycosphingolipid Clearance and Clinical Effects of Switching to Agalsidase Beta (Fabrazyme) Versus Continuing on Agalsidase Alfa (Replagal) in Male Patients With Classic Fabry Disease
Status: WITHDRAWN
Conditions: Fabry Disease
Interventions: DRUG: agalsidase beta (GZ419828)|DRUG: agalsidase alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Market Clinical Follow-up Performance and Safety Study of Etermis 3 and 4 in the Face
Status: COMPLETED
Conditions: Correction of Facial Wrinkles/Folds|Facial Volume Enhancement
Interventions: DEVICE: Etermis 3|DEVICE: Etermis 4
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Our Family Our Future: A Resilience-oriented Family Intervention to Prevent Adolescent HIV/STI Infection and Depression in South Africa
Status: ACTIVE_NOT_RECRUITING
Conditions: Human Immunodeficiency Virus|Depression|Sexually Transmitted Diseases
Interventions: BEHAVIORAL: Our Family Our Future
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multimodality Imaging Assessment of the Severity of Mitral Regurgitation
Status: RECRUITING
Conditions: Mitral Regurgitation
Interventions: OTHER: rehydration|DIAGNOSTIC_TEST: UCG|DIAGNOSTIC_TEST: CMR|OTHER: fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of the Use of Chartis System to Optimize Subject Selection for Endobronchial Lung Volume Reduction (ELVR)
Status: COMPLETED
Conditions: Emphysema
Interventions: DEVICE: Chartis System|DEVICE: Endobronchial Valve (EBV) Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Study of HKI-272 (Neratinib) in Combination With Paclitaxel (Taxol) in Subjects With Solid Tumors and Breast Cancer
Status: COMPLETED
Conditions: Advanced Breast Cancer|Advanced Malignant Solid Tumors|Breast Neoplasms
Interventions: DRUG: HKI-272|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide or Denileukin Diftitox Followed By Expanding a Patient's Own T Cells in the Laboratory in Treating Patients With HER-2/Neu Overexpressing Metastatic Breast Cancer, Ovarian Cancer, or Non-Small Cell Lung Cancer Previously Treated With HER-2/Neu Vaccine
Status: COMPLETED
Conditions: HER2-positive Breast Cancer|Recurrent Breast Cancer|Recurrent Non-small Cell Lung Cancer|Recurrent Ovarian Epithelial Cancer|Recurrent Ovarian Germ Cell Tumor|Stage IV Breast Cancer|Stage IV Non-small Cell Lung Cancer|Stage IV Ovarian Epithelial Cancer|Stage IV Ovarian Germ Cell Tumor
Interventions: DRUG: ex vivo-expanded HER2-specific T cells|DRUG: cyclophosphamide|BIOLOGICAL: denileukin diftitox|OTHER: flow cytometry|OTHER: immunoenzyme technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Antioxidant Vitamin Supplementation on Muscle Performance and Redox Status After Eccentric Training
Status: COMPLETED
Conditions: Muscle Damage|Oxidative Stress|Hemolysis
Interventions: DIETARY_SUPPLEMENT: Antioxidant vitamins
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Heal-Me Personalized Online Nutrition and Exercise Routines
Status: COMPLETED
Conditions: Cancer|Lung Diseases|Liver Diseases
Interventions: OTHER: Exercise & Nutrition|OTHER: Exercise & Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nutritional Interventions in Peritoneal Dialysis Patients With Hypoalbuminemia
Status: ACTIVE_NOT_RECRUITING
Conditions: End Stage Renal Disease on Dialysis
Interventions: DIETARY_SUPPLEMENT: Whey protein supplements|OTHER: Nutritional counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT