pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparison Between the Onlay and Inlay Techniques for Patellar Resurfacing in Posterior Cruciate Ligament-Substituting Total Knee Arthroplasty
Status: COMPLETED
Conditions: Onlay Patellar Resurfacing Technique|Inlay Patellar Resurfacing Technique|Patellar Resurfacing
Interventions: PROCEDURE: Total knee with onlay patellar resurfacing technique|PROCEDURE: Total knee with inlay patellar resurfacing technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Assess the Effect of Change of Bile Acid on the PD and Safety of Metformin and Microbiome Profiles
Status: COMPLETED
Conditions: Human Microbiome
Interventions: DRUG: Cholestyramine Resin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prediction of ECT Treatment Response and Reduction of Cognitive Side-effects Using EEG and Rivastigmine
Status: RECRUITING
Conditions: Depressive Disorder
Interventions: DRUG: Rivastigmine Transdermal Product|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Diagnostic and Prognostic Value of TAT, PIC, tPAI·C and TM in Sepsis-induced Coagulopathy
Status: NOT_YET_RECRUITING
Conditions: Sepsis-induced Coagulopathy
Interventions: DIAGNOSTIC_TEST: Test thrombin-antithrombin complex（TAT）, α2-plasmin inhibitor-plasmin complex（PIC）, tissue plasminogen activator-inhibitor complex（tPAI·C） and thrombomodulin（TM）
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Aortic Stenosis Pre-Transcatheter Aortic Valve Replacement (TAVR) Procedure CT Scan
Status: COMPLETED
Conditions: Aortic Valve Stenosis
Interventions: DRUG: Low-volume, low-concentration contrast (iodixanol - Visipaque 270) CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hepatic Arterial Infusion Chemotherapy in Combination With Atezolizumab and Bevacizumab for Second-line Treatment of Patients With Recurrent Liver Cancer After Liver Transplantation
Status: RECRUITING
Conditions: Recurrent Liver Cancer After Liver Transplantation
Interventions: DRUG: Hepatic arterial infusion chemotherapy + Atezolizumab and bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Dual Combination of Product (Budesonide and Formoterol) Given Via Two Different Inhalers. To See Which One Results in the Best Effect on Breathing.
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: COMBINATION_PRODUCT: BFF|COMBINATION_PRODUCT: Symbicort Turbuhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial of Bifocal Lenses Versus Computer-specific Progressive Addition Lenses
Status: TERMINATED
Conditions: Refractive Error|Presbyopia|Asthenopia|Eyeglasses
Interventions: DEVICE: D-28 bifocal lenses and frame|DEVICE: Progressive addition computer lenses and frame
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effect of Chlorine Dioxide and Chlorhexidine Mouthwash on Bad Breath
Status: NOT_YET_RECRUITING
Conditions: Halitosis
Interventions: PROCEDURE: Chlorine dioxide mouthwash|PROCEDURE: Chlorhexidine mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Estrogen Priming to Increase the Efficacy of Adjuvant Chemotherapy in Operable Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Tab Premarin (Ethinyl estradiol)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Bevacizumab for Retinal Disorders
Status: UNKNOWN
Conditions: Wet AMD|Macular Oedema|Proliferative Diabetic Retinopathy
Interventions: DRUG: Bevacizumab ( Avastin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Placebo- and Ropinirole-Controlled Study for SPM 962 in Advanced Parkinson's Disease Patients
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: SPM 962|DRUG: Ropinirole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis Pigmentosa Due to the P23H Mutation in the RHO Gene
Status: ACTIVE_NOT_RECRUITING
Conditions: Autosomal Dominant Retinitis Pigmentosa|Eye Diseases|Eye Diseases, Hereditary|Retinal Dystrophies|Retinal Disease|Retinitis|Vision Tunnel|Vision Disorders
Interventions: DRUG: QR-1123|OTHER: Sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Induction of Donor Specific Tolerance in Recipients of Living Kidney Allografts by Donor FCRx Infusion
Status: TERMINATED
Conditions: Kidney Failure
Interventions: BIOLOGICAL: Enriched Hematopoietic Stem Cell Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of an E-health Intervention in Patients With Obstructive Sleep Apnoea
Status: RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: BEHAVIORAL: Patient education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TirolGESUND: Baseline-controlled Comparison of the Effects of Fasting Dietary Intervention or Smoking Cessation Combined With Exercise in Healthy Female Tyrolean Volunteers Aged 30-60 on Epigenetic and Multi-omic Biomarkers of Health, Ageing, and Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy|Healthy Lifestyle|Smoking Cessation|Intermittent Fasting
Interventions: BEHAVIORAL: Smoking cessation|BEHAVIORAL: Intermittent fasting|BEHAVIORAL: Intermittent fasting with ketogenic supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Investigate the Safety, Tolerability and Pharmacodynamics of GSK2890457 in Healthy Volunteers and Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: GSK2890457|DRUG: Metformin|DRUG: Placebo|DRUG: Liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study of IDEAL (Imatinib) for Chronic Myelgenous Leukemia (CML)
Status: WITHDRAWN
Conditions: Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Interventions: DRUG: IDEAL-E observation (investigators choice of imatinib, nilotinib, dasatinib, radotinib)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparing Interventions To Improve The Well-Being Of Custodial Grandfamilies
Status: COMPLETED
Conditions: Custodial Grandparents
Interventions: BEHAVIORAL: Behavioral Parent Training|BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Psychosocial-Informational support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study for Japanese Participants With Rheumatoid Arthritis (RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: LY2127399 (Tabalumab)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of CBL-514 in Participants With EFP; Cellulite (Stage 1)
Status: COMPLETED
Conditions: Cellulite
Interventions: DRUG: 40 mg CBL-514|DRUG: 60 mg CBL-514|DRUG: 80 mg CBL-514
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PENG Block Versus Fascia Iliaca Block for Pre- and Post-Operative Analgesia in Elderly Patients With Hip Fracture
Status: UNKNOWN
Conditions: Hip Fractures
Interventions: PROCEDURE: Pericapsular nerve Group block|PROCEDURE: Facia Iliaca block|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Perioperative Intravenous Dexamethasone in Clinical Outcomes After Total Knee Arthroplasty in a Hispanic Population
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Dexamethasone|DRUG: Morphine|DRUG: Oxycodone and acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Copeptin Testing During Pre-hospital Care in the Treatment of Chest Pain Suggestive of Acute Coronary Syndrome
Status: COMPLETED
Conditions: Chest Pain
Interventions: BIOLOGICAL: Blood work in the ambulance|BIOLOGICAL: Blood work upon arrival in the emergency room|BIOLOGICAL: Blood work at 3 hours post-arrival in the emergency room
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ultrasound Guided Popliteal Fossa Block. Does Blockade Distal to Sciatic Nerve Bifurcation Speed Onset Time? A Prospective, Randomized Trial
Status: COMPLETED
Conditions: Ankle/Foot Surgery
Interventions: PROCEDURE: Sciatic nerve blockade for ankle/foot surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of IV Ibuprofen vs IV Acetaminophen Post Surgical Extraction
Status: UNKNOWN
Conditions: Impacted Wisdom Teeth
Interventions: DRUG: Caldolor|DRUG: Ofirmev
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Rising Dose Regimens of BIA 5-453
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Placebo|DRUG: BIA 5-453
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MuLtimodality EvaluatiOn of aNtibody mEdiated Damage in Heart Transplantation (LEONE-HT)
Status: ACTIVE_NOT_RECRUITING
Conditions: Transplant Failure|Heart Transplant Rejection|Antibody-mediated Rejection
Interventions: DIAGNOSTIC_TEST: Echocardiogram|DIAGNOSTIC_TEST: Cardiac magnetic resonance|DIAGNOSTIC_TEST: Coronary angiography|DIAGNOSTIC_TEST: Endomyocardial biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Product Performance of a Daily Disposable Contact Lens
Status: COMPLETED
Conditions: Myopia|Contact Lenses
Interventions: DEVICE: Bausch & Lomb new daily disposable|DEVICE: Johnson & Johnson Acuvue Moist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Monitoring and Evaluation of Posture in Office Workstations With Artificial Intelligence
Status: COMPLETED
Conditions: Musculoskeletal Pain|Musculoskeletal Injury|Musculoskeletal Strain
Interventions: BEHAVIORAL: Workstation Modification
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Basal Bolus of Insulin Aspart Including Insulin NPH and Biphasic Insulin Aspart in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart|DRUG: insulin NPH|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VELOCITY: An Anthrax Vaccine Clinical Study
Status: COMPLETED
Conditions: Anthrax
Interventions: BIOLOGICAL: AV7909|BIOLOGICAL: BioThrax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Paxerol™ for Treatment of Nocturia - A Phase II Placebo-Controlled Trial
Status: COMPLETED
Conditions: Nocturia
Interventions: OTHER: Placebo|DRUG: Paxerol - Dose Level 1|DRUG: Paxerol - Dose Level 2|DRUG: Paxerol - Dose Level 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Cranberry Extractive on the Lipid Profiles in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: cranberry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Investigation of the Decoria® Aesthetic Group (DAG) for Correction of Nasolabial Folds (NLF)
Status: COMPLETED
Conditions: Correction of Nasolabial Folds
Interventions: DEVICE: Decoria intense
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Combination Chemotherapy With or Without Donor Bone Marrow Transplantation in Treating Infants With Previously Untreated Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: asparaginase|DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: methylprednisolone|DRUG: pegaspargase|DRUG: thioguanine|DRUG: vincristine sulfate|PROCEDURE: allogeneic bone marrow transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Sinus Surgery for Refractory Chronic Sinusitis
Status: UNKNOWN
Conditions: Sinusitis
Interventions: PROCEDURE: Endoscopic sinus surgery + Septoplasty|PROCEDURE: Septoplasty alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ID-JPL934 for Abnormal Bowel Movement
Status: UNKNOWN
Conditions: Abnormal Bowel Movement Such as Constipation, Diarrhea, Abdominal Pain
Interventions: DIETARY_SUPPLEMENT: ID-JPL934|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Vonoprazan Compared to Lansoprazole in Participants With Erosive Esophagitis
Status: COMPLETED
Conditions: Erosive Esophagitis
Interventions: DRUG: Vonoprazan|DRUG: Lansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Effectiveness of the Antiobesity Medication Phentermine
Status: RECRUITING
Conditions: Obesity|Obesity; Drug|Lifestyle, Healthy
Interventions: BEHAVIORAL: Online Lifestyle Behavioral Therapy|DRUG: Phentermine Hydrochloride 8 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Impact of VEGF Polymorphism on the Development of Renal Carcinoma in Renal Transplant Patients
Status: UNKNOWN
Conditions: Polymorphism|VEGF|Renal Carcinoma|Renal Transplantation
Interventions: GENETIC: To study the polymorphism of the gene encoding VEGF (rs699947) as a predictive marker
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Biofeedback and Hydrogen Water as Treatments for Chronic Fatigue Syndrome
Status: UNKNOWN
Conditions: Chronic Fatigue Syndrome
Interventions: BEHAVIORAL: Heart Rhythm Biofeedback|DIETARY_SUPPLEMENT: Hydrogen Water|COMBINATION_PRODUCT: Combined treatment: Heart rhythm biofeedback plus hydrogen water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VIGADEXA Gel Compared to VIGADEXA Solution Following Cataract Surgery
Status: WITHDRAWN
Conditions: Cataracts
Interventions: DRUG: Moxifloxacin 0.5%/Dexamethasone Phosphate 0.075% Ophthalmic Gel (VIGADEXA Gel)|DRUG: Moxifloxacin 0.5%/Dexamethasone Phosphate 0.1% Ophthalmic Solution (VIGADEXA Solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Alternating Energy Intake and Blood Fat Content After a Meal
Status: UNKNOWN
Conditions: Abdominal Obesity|Postprandial Lipemia|Lipid Metabolism|Glucose Metabolism
Interventions: OTHER: Alternating Energy Intake|OTHER: Regular Energy Intake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Randomized Phase III Study Comparing POF With SOX/CAPOX/FOLFOX as a Postoperative Adjuvant Chemotherapy for Curatively Resected Stage III Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer Stage III
Interventions: DRUG: POF|DRUG: CAPOX/SOX/FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Compare the Efficacy of Systane Ultra and Refresh Drop in the Treatment of Dry Eye in Asian Eyes
Status: COMPLETED
Conditions: Xerophthalmia|Blepharitis
Interventions: DRUG: Systane Ultra eyedrops|DRUG: Refresh eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Basket Study of Neratinib in Participants With Solid Tumors Harboring Somatic HER2 or EGFR Exon 18 Mutations
Status: TERMINATED
Conditions: Solid Tumors Harboring Somatic HER2 or EGFR Exon 18 Mutations
Interventions: DRUG: Neratinib|DRUG: Fulvestrant|DRUG: Trastuzumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Timing of Complete Revascularization in Patients With ST-segment Elevation Myocardial Infarction And Multivessel Disease
Status: NOT_YET_RECRUITING
Conditions: ST-elevation Myocardial Infarction|Multivessel Coronary Disease
Interventions: PROCEDURE: Immediately CR|PROCEDURE: Staged (within 45 days) CR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary Organoid Models and Combined Nucleic Acids Therapeutics for Anti-HPV Treatments
Status: RECRUITING
Conditions: HPV Infection|Vaginal Cancer|Cervical Dysplasia|Cervical Cancer
Interventions: PROCEDURE: Vaginal Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DRUG: Ketamine|BEHAVIORAL: Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Third Dose Vaccination With AstraZeneca or Pfizer COVID-19 Vaccine Among Adults Received Sinovac COVID-19 Vaccine
Status: COMPLETED
Conditions: COVID-19 Infection|COVID-19 VACCINE
Interventions: BIOLOGICAL: AstraZeneca ChAdOx1 AZD1222 vaccine (AZ) full dose|BIOLOGICAL: Pfizer/BioNTech BNT162b2 vaccine (PF) full dose|BIOLOGICAL: AstraZeneca ChAdOx1 AZD1222 vaccine (AZ) half dose|BIOLOGICAL: Pfizer/BioNTech BNT162b2 vaccine (PF) half dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Study of Everolimus in Children and Adolescents With Refractory or Relapsed Osteosarcoma
Status: UNKNOWN
Conditions: Refractory or Relapsed Osteosarcoma
Interventions: DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2a Clinical Trial of HL237 for Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: HL237 tablet|DRUG: Placebo of HL237 tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Transcranial Direct Current Stimulation in Chronic Pain Related to Lumbar Spinal Stenosis
Status: UNKNOWN
Conditions: Lumbar Spinal Stenosis
Interventions: DEVICE: active tDCS|DEVICE: sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and PK Trial With Injectable ZX003 (Risperidone-SABER®) Compared to Risperdal® Consta® in Stable Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: ZX003 (Risperidone-SABER®)|DRUG: Risperdal Consta|DRUG: Oral Risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dysport in the Treatment of Glabellar Lines in Chinese Subjects
Status: COMPLETED
Conditions: Glabellar Lines
Interventions: BIOLOGICAL: Botulinum toxin type A|BIOLOGICAL: Botulinum toxin type A|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Studying Tissue Samples From Women Who Underwent Chemotherapy for Lymph Node-Positive Stage II or Stage IIIA Breast Cancer on Clinical Trial CLB-9741 or CLB-9344
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: paclitaxel|GENETIC: fluorescence in situ hybridization|OTHER: immunohistochemistry staining method
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability and Clinical Activity of ASM-024 in Stable Moderate Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: ASM-024|DRUG: ASM-024 100 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation in Reducing Pain in Cancer Patients With Chemotherapy Induced Peripheral Neuropathy
Status: WITHDRAWN
Conditions: Chemotherapy-Induced Peripheral Neuropathy|Malignant Neoplasm
Interventions: OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Cabozantinib (XL184) vs Placebo in Subjects With Hepatocellular Carcinoma Who Have Received Prior Sorafenib
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Cabozantinib tablets|DRUG: Placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Stellate Ganglion Block in Children With Cerebral Palsy and Dysphagia
Status: WITHDRAWN
Conditions: Cerebral Palsy
Interventions: BEHAVIORAL: routine rehabilitation treatment|PROCEDURE: Stellate ganglion block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Shexiang Baoxin Pill in Patients With Ischemia With Non-Obstructive Coronary Artery
Status: COMPLETED
Conditions: Ischemia With Non-Obstructive Coronary Artery|Angina Pectoris|Coronary Heart Disease|X Syndrome, Angina
Interventions: RADIATION: Shexiang Baoxin pill（MUSKARDIA）|RADIATION: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of AK104 or AK112 in Combination With Axitinib in Patients With Metastatic Mucosal Melanoma
Status: NOT_YET_RECRUITING
Conditions: Melanoma|Mucosal Melanoma|Metastatic Melanoma
Interventions: DRUG: AK104+Axitinib|DRUG: AK112+Axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vancomycin Powder and Dilute Povidone Iodine Lavage for Infection Prophylaxis in High Risk Total Joint Arthroplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis
Interventions: DRUG: Povidone iodine|DRUG: Vancomycin powder|OTHER: Conventional
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conventional Laparoscopic Versus Laparoendoscopic Single Site Donor Nephrectomy in Living Donor Kidney Transplantation
Status: COMPLETED
Conditions: Living Donors|Nephrectomy|Kidney Transplantation|Surgery, Laparoscopic
Interventions: PROCEDURE: Laparoendoscopic single site donor nephrectomy|PROCEDURE: Conventional laparoscopic donor nephrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protein Turnover in Preterm Infants - Feeding of Target Fortified Breast Milk With Different Macronutrient Composition to Improve Growth
Status: RECRUITING
Conditions: Infant Development|Protein-energy; Imbalance|Protein Deposition
Interventions: DIETARY_SUPPLEMENT: Macronutrients_CARB|DIETARY_SUPPLEMENT: Macronutrient_FAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: EUS-Guided Rendezvous or Direct Interventions Versus Advanced ERCP Techniques for Biliary Access and Therapy
Status: COMPLETED
Conditions: Disorders of Gallbladder|Disorders of Biliary Tract
Interventions: PROCEDURE: EUS-Rendezvous or direct intervention|PROCEDURE: Advanced ERCP Biliary Access Techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY2886721 in Healthy Participants and Participants Diagnosed With Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease|Healthy Volunteers
Interventions: DRUG: LY2886721|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Probiotic Blend Reduces Gastrointestinal Symptoms and Positively Impacts Microbiota Modulation in a Randomized Study
Status: COMPLETED
Conditions: Microbiota|Constipation|Candida
Interventions: DIETARY_SUPPLEMENT: 575mg [30 billion colony forming units] probiotic blend of Bifidobacterium breve, Lactobacillus acidophilus, Lacticaseibacillus rhamnosus, Saccharomyces boulardii, and alpha amylase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lutetium 177Lu-Edotreotide Versus Best Standard of Care in Well-differentiated Aggressive Grade-2 and Grade-3 GastroEnteroPancreatic NeuroEndocrine Tumors (GEP-NETs) - COMPOSE
Status: RECRUITING
Conditions: Neuroendocrine Tumors
Interventions: DRUG: 177Lu-Edotreotide (Peptide Receptor Radionuclide Therapy) PRRT|DRUG: CAPTEM (Capecitabine and Temozolomide)|OTHER: Amino-Acid Solution|DRUG: Everolimus|DRUG: FOLFOX (Folinic acid + Fluorouracil + Oxaliplatin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Behavioral and Cognitive Effects of the N-methyl-D-aspartate Receptor (NMDAR) Co-agonist D-serine in Healthy Humans
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: D-serine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Intermediate Dose of IV MTX as CNS Prophylaxis for High Risk DLBCL
Status: RECRUITING
Conditions: Diffuse Large B Cell Lymphoma|Central Nervous System Lymphoma
Interventions: DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrating Geriatric Assessment for Older Patients Diagnosed With Acute Myelogenous Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: BEHAVIORAL: modified Geriatric Assessment (mGA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Free DNA and Nucleosome Concentrations in Pathological Pregnancies
Status: COMPLETED
Conditions: Pregnancy|Venous Thrombosis|Pulmonary Embolism|Hypertension, Pregnancy-Induced|Eclampsia|HELLP Syndrome|Pre-Eclampsia|Fetal Death|Placental Insufficiency
Interventions: BIOLOGICAL: Bloodwork, baseline|BIOLOGICAL: Blood work, Months 1 & 2|BIOLOGICAL: Bloodwork, Months -1 to -6
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Open, Prospective, Randomized, Multicenter Study of the Efficacy and Safety of Intravenous Followed by Oral Azithromycin Versus Cefuroxime Alone or With Oral Erythromycin for the Treatment of Chinese Patients Who Were Hospitalized for Pneumonia
Status: COMPLETED
Conditions: Pneumonia
Interventions: DRUG: cefuroxime plus erythromycin|DRUG: azithromycin (Zithromax)|DRUG: cefuroxime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Lycopene on High Risk Prostatic Tissue
Status: COMPLETED
Conditions: Intraepithelial Prostatic Neoplasia|Prostatic Neoplasms
Interventions: DRUG: Lycopene 30mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Avastin vs Visudyne for Neovascular AMD Study
Status: WITHDRAWN
Conditions: Age-related Macular Degeneration
Interventions: DRUG: Bevacizumab (Avastin)|DRUG: Verteporfin photodynamic therapy (PDT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of CP-778,875 on HDL-C in Subjects With Abnormal Lipid Levels and Type 2 Diabetes.
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: CP-778,875
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Digital Patient Journey Solution for Patients Undergoing Elective Hip and Knee Arthroplasty Dueto Primary Osteoarthritis
Status: COMPLETED
Conditions: Primary Elective Hip Arthroplasty (THA)|Primary Elective Total Knee Arthroplasty (TKA)
Interventions: DEVICE: Digital Patient Journey Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Alprazolam Extended-Release 3mg Tablets Bioequivalence Study Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Alprazolam Extended-Release 3 mg Tablets|DRUG: Alprazolam Extended-Release 3 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Preference of Room Setting and Waiting Time in Patients With Advanced, Locally Advanced, or Metastatic Cancer and Their Caregivers Who Are Seen in the Outpatient Supportive/Palliative Care Center
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Neoplasm|Caregiver|Locally Advanced Malignant Neoplasm|Metastatic Malignant Neoplasm
Interventions: OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Comparison of Three Medications to Treat Diarrhea in Adults.
Status: COMPLETED
Conditions: Diarrhea
Interventions: DRUG: Loperamide/simeticone 2 mg/125 mg caplets|DRUG: Loperamide/simeticone 2 mg/125 mg chewable tablets|DRUG: Probiotic Saccharomyces boulardii 250 mg capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease
Status: UNKNOWN
Conditions: Non-alcoholic Fatty Liver Disease (NAFLD)
Interventions: DRUG: Metabolic Cofactor Supplementation|DRUG: Sorbitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Peritoneal Dialysis Catheters for the Treatment of Refractory Ascites
Status: COMPLETED
Conditions: Liver Cirrhosis|Ascites
Interventions: DEVICE: Peritoneal Dialysis Catheter|PROCEDURE: Large Volume Paracentesis|BIOLOGICAL: 25% Human Serum Albumin injection|PROCEDURE: Bloodwork
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Efalizumab in Adult Patients With Plaque Psoriasis Involving the Hands and/or Feet
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: efalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Donor EBV-CTL Infusion in Patients With CAEBV and EBV-HLH After Allo-HSCT
Status: RECRUITING
Conditions: Chronic Active Epstein-Barr Virus Infection|Virus-Associated Hemophagocytic Syndrome
Interventions: OTHER: donor EBV-specific T lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Escalating Doses of Romidepsin in Association With CHOP in the Treatment of Peripheral T-Cell Lymphomas
Status: COMPLETED
Conditions: Peripheral T Cell Lymphoma
Interventions: DRUG: Romidepsin and CHOP|DRUG: Romidepsin and CHOP|DRUG: Romidepsin and CHOP|DRUG: Romidepsin and CHOP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: INTERCOSTAL NERVE BLOCK: Efficacy of CINB for Patients With Multiple Rib Fractures
Status: RECRUITING
Conditions: Rib Fractures
Interventions: DRUG: Ropivacaine|DRUG: Non steroidal anti-inflammatory drug and opioids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flumatinib Versus Nilotinib for Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia
Status: RECRUITING
Conditions: CML, Chronic Phase; TKI
Interventions: DRUG: Flumatinib Mesylate|DRUG: Nilotinib Pill
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Subthreshold Laser Treatment Versus Threshold Laser Treatment for Symptomatic Retinal Arterial Macroaneurysm
Status: COMPLETED
Conditions: Aneurysm
Interventions: DEVICE: subthreshold and threshold laser treatment|DEVICE: Threshold laser treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Surgical Decisions in Young Adults With Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer Stage 0|Breast Cancer Stage I|Breast Cancer Stage II|Breast Cancer Stage III
Interventions: OTHER: CONSYDER decision aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety, Reactogenicity and Immunogenicity of GlaxoSmithKline (GSK) Biologicals' Non-typeable Haemophilus Influenzae (NTHI) Vaccine
Status: COMPLETED
Conditions: Respiratory Disorders
Interventions: BIOLOGICAL: GSK Biologicals' Non-Typeable H. influenzae (GSK2838500A)|BIOLOGICAL: GSK Biologicals' Non-Typeable H. influenzae (GSK2838501A)|BIOLOGICAL: Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Is Conventional TR Band Deflation Protocol Inferior to Internationally Developed TR Band Removal Protocol in Reducing Occurrence of Radial Artery Occlusion
Status: COMPLETED
Conditions: Radial Artery Occlusion
Interventions: PROCEDURE: TR BAND removal protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Monitoring the Efficacy of Anthelmintics for the Treatment of Soil Transmitted Helminths P2
Status: COMPLETED
Conditions: Ascaris Lumbricoides|Ascaris Suum|Trichuris Trichiura|Trichuris Vulpis|Ancylostoma Duodenal|Ancylostoma Caninum|Ancylostoma Ceylanicum|Necator Americanus
Interventions: DRUG: Mebendazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Mianserin in Combination With SSRIs in Depression With Sleep Problems
Status: RECRUITING
Conditions: Depression
Interventions: DRUG: Mianserin|DRUG: Lorazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does a Group, Task-oriented Community-based Exercise Program Improve Everyday Function in People With Stroke?
Status: COMPLETED
Conditions: Stroke|Balance|Mobility Limitation|Activities of Daily Living
Interventions: BEHAVIORAL: Together in Movement and Exercise (TIME) Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Levosimendan Infusion for Patients With Advanced Chronic Heart Failure
Status: UNKNOWN
Conditions: Heart Failure
Interventions: DRUG: Levosimendan 2.5 MG/ML|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanical Ventilation Reconnection for One Hour After Spontaneous Breathing Trial
Status: RECRUITING
Conditions: Airway Extubation|Ventilator Weaning
Interventions: OTHER: Reconnection to mechanical ventilation for 1 hour|OTHER: Direct extubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Evaluation of a New Nasal Mask for the Treatment of Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Device: Trial nasal mask (F&P)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Crossover Study of the Acute Effects of Olanzapine in Healthy Volunteers
Status: COMPLETED
Conditions: Insulin Resistance|Diabetes Mellitus
Interventions: DRUG: Olanzapine 10 mg po qhs for 3 days|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fish Oil Trials in Pregnancy for the Prevention of Pregnancy Complications ('FOTIP')
Status: COMPLETED
Conditions: Preterm Birth|Intrauterine Growth Retardation|Pregnancy Induced Hypertension
Interventions: DIETARY_SUPPLEMENT: Low dose fish oil|DIETARY_SUPPLEMENT: Low dose olive oil|DIETARY_SUPPLEMENT: High dose fish oil|DIETARY_SUPPLEMENT: High dose olive oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Antineoplaston Therapy in Treating Patients With Cancer of Unknown Primary Origin
Status: TERMINATED
Conditions: Unknown Primary Carcinoma
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PD-1 Antibody Combined With Chemoradiotherapy in Recurrent Nasopharyngeal Carcinoma Patients
Status: RECRUITING
Conditions: Recurrent Nasopharyngeal Carcinoma
Interventions: DRUG: PD-1 blocking antibody|DRUG: GP|RADIATION: IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Compare the Pharmacokinetics of Tralokinumab in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tralokinumab administered as 1 × X mL with Device A|DEVICE: Tralokinumab administered as 2 × Y mL with Device B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Electronic and Mail Outreach From Primary Care Physicians for COVID-19 Vaccination Among Elderly Patients
Status: COMPLETED
Conditions: Vaccination
Interventions: BEHAVIORAL: Standard PCP Outreach|BEHAVIORAL: Culturally Tailored PCP Outreach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Extension Study of Protocol ENB-006-09 - Study of Asfotase Alfa in Children With Hypophosphatasia (HPP)
Status: COMPLETED
Conditions: Hypophosphatasia (HPP)
Interventions: BIOLOGICAL: Asfotase Alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Canakinumab in High-Risk Former-Smokers
Status: RECRUITING
Conditions: Cigarette Smoking-Related Carcinoma|Lung Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bronchoscopy|BIOLOGICAL: Canakinumab|PROCEDURE: Carbon Monoxide Measurement|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: KSD-101 Therapy for Standard Treatment Failed EBV-associated NPC: an Exploratory Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: BIOLOGICAL: KSD-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Pharmacokinetics (PK), Safety, Tolerability of Single-Dose Transdermal Rotigotine in Japanese and Caucasian Healthy Male / Female Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rotigotine transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Outcome of Zeiss AT LARA EDOF Lens Implantation in Vitrectomized Eyes
Status: COMPLETED
Conditions: Vitreous Disorder|Cataract
Interventions: PROCEDURE: intraocular lens implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Aplidin - Dexamethasone in Relapsed/Refractory Myeloma
Status: COMPLETED
Conditions: Relapsed/Refractory Multiple Myeloma
Interventions: DRUG: Plitidepsin|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Sequential Therapy of S1+Docetaxel Followed by S1 to Concomitant S1+Docetaxel for Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: S1+Docetaxel|DRUG: S1+Docetaxel followed by S1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Y-TZP and In-mouth Low Thermal Degradation: A Prospective Clinical Study
Status: UNKNOWN
Conditions: Zirconia Monolithic Dental Restorations: In-mouth Behaviour, LTD and Wear
Interventions: DEVICE: Lava plus (3M) crowns and bridges
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Curcumin and Piperine in Reducing Inflammation for Ureteral Stent-Induced Symptoms in Patients With Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Bladder Spasm|Malignant Neoplasm|Pain|Urinary Urgency
Interventions: DRUG: Curcumin|OTHER: Laboratory Biomarker Analysis|DIETARY_SUPPLEMENT: Piperine Extract (Standardized)|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE