pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Preventing Recurrent Urinary Tract Infections With α-D-mannose
Status: TERMINATED
Conditions: Urinary Tract Infections
Interventions: DRUG: Mannose|DRUG: Lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Trial of Stereotactic Body Radiotherapy (SBRT) After Induction Chemotherapy for Locally Advanced Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer
Interventions: RADIATION: Stereotactic Body Radiotherapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sedentarism of Stroke Survivors in the Valencian Community and Development of a Self-management Program
Status: RECRUITING
Conditions: Stroke Sequelae
Interventions: OTHER: Self-management program to increase physical activity levels|OTHER: Education information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SELF-GYN1 (Sonograms Enable Looking Forward- Get Your iNformation 1 Trial)
Status: COMPLETED
Conditions: Fertility Risk
Interventions: DEVICE: Transvaginal ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Probiotic vs Placebo on Cognition Outcomes in Patients With Bipolar Disorder
Status: RECRUITING
Conditions: Bipolar Disorder
Interventions: DIETARY_SUPPLEMENT: probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Robotically Augmented Mental Practice
Status: COMPLETED
Conditions: Stroke
Interventions: BEHAVIORAL: Visual motor imagery (MI)|BEHAVIORAL: Kinesthetic MI|BEHAVIORAL: Robotic-Hand Interaction with MI|BEHAVIORAL: Robotic-Hand Interaction without MI|BEHAVIORAL: Virtual-Hand Interaction|BEHAVIORAL: Robotic Action Observation|BEHAVIORAL: Rest
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Incidence and Risk Factors of Radiotherapy Induced Hypothyroidism in Head and Neck Cancer With Long Term Follow up
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DIAGNOSTIC_TEST: TSH, T3, T4 and thyroid gland DVH
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Evaluation of Aranesp® in Subjects With Anaemic Chronic Kidney Disease (CKD)
Status: COMPLETED
Conditions: Kidney Disease
Interventions: DRUG: Aranesp® (darbepoetin alfa)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Gemcitabine, Abraxane® Plus Placebo Versus Gemcitabine, Abraxane® Plus 1 or 2 Truncated Courses of Demcizumab in Subjects With 1st-Line Metastatic Pancreatic Ductal Adenocarcinoma
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Demcizumab|DRUG: Abraxane®|DRUG: gemcitabine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient-tailored Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Colorectal Peritoneal Metastases (OrganoHIPEC)
Status: RECRUITING
Conditions: Peritoneal Metastases From Colorectal Cancer
Interventions: PROCEDURE: Patient-tailored hyperthermic intraperitoneal chemotherapy (HIPEC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Levels of Pain and Discomfort and Periodontal Status Between Two Acceleration Methods of Upper Anterior Teeth Retraction
Status: COMPLETED
Conditions: Class II Malocclusion
Interventions: DEVICE: Piezocision+GaALAs diode laser|DEVICE: Piezocision|DEVICE: Orthodontic fixed appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Recipient Site Pre-conditioning in Fat Grafting
Status: RECRUITING
Conditions: Graft Loss|Condition
Interventions: DEVICE: pre-expansion using Kiwi® VAC-6000M.|DEVICE: pre-heating using Hilotherm Calido®.|DEVICE: pre-expansion-heating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: rTMS Feasibility Study on Adolescent Depression Stimulation
Status: ENROLLING_BY_INVITATION
Conditions: Major Depressive Disorder|Unipolar Depression|Bipolar Depression
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Cardioselective β-blockers on Dynamic Hyperinflation in COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Bisoprolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Atezolizumab Plus Bevacizumab Versus Active Surveillance as Adjuvant Therapy in Patients With Hepatocellular Carcinoma at High Risk of Recurrence After Surgical Resection or Ablation
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy, Cisplatin, and Etoposide in Treating Patients With Non-small Cell Lung Cancer That Cannot Be Removed by Surgery
Status: TERMINATED
Conditions: Recurrent Non-small Cell Lung Cancer|Stage IIB Non-small Cell Lung Cancer|Stage IIIA Non-small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer
Interventions: RADIATION: 3-dimensional conformal radiation therapy|RADIATION: intensity-modulated radiation therapy|DRUG: cisplatin|DRUG: etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of L-Arabinose and D-xylose on Intestinal Sucrase Activity in Man
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: Placebo comparator: 0% pentose|DIETARY_SUPPLEMENT: Active comparator: 4% D-xylose|DIETARY_SUPPLEMENT: Active comparator: 8% D-xylose|DIETARY_SUPPLEMENT: Active comparator: 8% L-arabinose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Intelligent Needle Tip Tracking Using Ultrasound Imaging for Lumbar Plexus Blocks
Status: COMPLETED
Conditions: Nerve Block
Interventions: PROCEDURE: Lumbar plexus block using NTT|PROCEDURE: Lumbar plexus block without NTT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of Low Molecular Weight Heparin in Superficial Vein Thrombosis
Status: COMPLETED
Conditions: Superficial Thrombophlebitis
Interventions: DRUG: Dalteparin|DRUG: Dalteparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Add-on Therapy With Low Dose Fenfluramine in Lennox Gastaut Epilepsy
Status: ACTIVE_NOT_RECRUITING
Conditions: Epilepsy|Lennox Gastaut Syndrome
Interventions: DRUG: Fenfluramine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Home-Based Rehabilitation Treatments Among Persons With Symptomatic Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: OTHER: KBA exercise|OTHER: strength training exercise|OTHER: KBA and strength training|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of IPI-549 Combined With Front-line Treatments in Pts. With Triple-Negative Breast Cancer or Renal Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Renal Cell Carcinoma
Interventions: DRUG: IPI-549 (eganelisib)|DRUG: Atezolizumab|DRUG: nab-paclitaxel|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Two Formulations of Rivaroxaban Tablets 20 mg in Healthy Male Volunteers Under Fed Conditions
Status: UNKNOWN
Conditions: Bioequivalence
Interventions: DRUG: Rivaroxaban film-coated tablet 20 mg|DRUG: Xarelto® film-coated tablet 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Safety and Efficacy of Humia Inj. in Patients With Symptomatic Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis of Knee
Interventions: DRUG: Humia inj.|DRUG: High hyal Plus inj.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide/Bortezomib/Dexamethasone & CNTO 328 in Transplant Eligible Newly Diagnosed Multiple Myeloma (MM)
Status: COMPLETED
Conditions: Myeloma
Interventions: DRUG: Lenalidomide|DRUG: Bortezomib|DRUG: Siltuximab|DRUG: Dexamethasone|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 4, Open-label Study of KRYSTEXXA® (Pegloticase) Co-administered With Methotrexate (MTX) in Patients With Uncontrolled Gout (FORWARD OL)
Status: COMPLETED
Conditions: Uncontrolled Gout|Chronic Gout
Interventions: BIOLOGICAL: Pegloticase|DRUG: Methotrexate (MTX)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Memantine to Reduce Neurocognitive Deficits Following Unilateral ECT for the Treatment of a Major Depression
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: memantine|DRUG: Placebo Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Modulation Effect of tACS on Chronic Low Back Pain
Status: NOT_YET_RECRUITING
Conditions: Chronic Low-back Pain
Interventions: DEVICE: Real tACS|DEVICE: Sham tACS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Immunogenicity of the Inactivated EV71 Vaccine Combined With Hepatitis B and Group A Meningococcal Vaccine
Status: ACTIVE_NOT_RECRUITING
Conditions: Hand, Foot and Mouth Disease
Interventions: BIOLOGICAL: Enterovirus Type 71 Vaccine, inactivated ( Human Diploid Cell )|BIOLOGICAL: Recombinant Hepatitis B Vaccine|BIOLOGICAL: Group A meningococcal polysaccharide vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Pheochromocytoma/Paraganglioma
Status: RECRUITING
Conditions: Pheochromocytoma|Paraganglioma
Interventions: DRUG: Axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Effect of Rosuvastatin on Inflammation in Patients Undergoing Isolated Cardiac Valve Surgery
Status: COMPLETED
Conditions: Valvular Cardiac Surgery
Interventions: DRUG: Rosuvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: REduCed Dose of TNFi in Patients With Ankylosing SpondyliTis (RECAST)
Status: NOT_YET_RECRUITING
Conditions: Ankylosing Spondylitis|Axial Spondyloarthritis
Interventions: BIOLOGICAL: Adalimumab and its biosimilars|BIOLOGICAL: Biological: Etanercept and its biosimilars|BIOLOGICAL: Golimumab|BIOLOGICAL: Infliximab biosimilar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Validated Diagnostic Prediction Model of Acute Heart Failure in the Emergency Department
Status: COMPLETED
Conditions: Dyspnea|Acute Heart Failure|Shortness of Breath
Interventions: OTHER: Treatment as per model probability|OTHER: Treatment as per usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetic Interactions of Valsartan and Hydrochlorothiazide (Double Doses)
Status: COMPLETED
Conditions: Healthy Normotensive Participants
Interventions: DRUG: Valsartan/Hydrochlorothiazide|DRUG: Valsartan|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Determining the Effectiveness of earLy Intensive Versus Escalation Approaches for RRMS
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Early Highly Effective Therapies Group|DRUG: Escalation Therapies Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Preemptive Treatment Strategies of Panitumumab Mediated Skin Toxicity and Assessment of QoL in Patient With Ras-wt Colorectal Cancer
Status: COMPLETED
Conditions: Ras-wildtype Colorectal Cancer
Interventions: DRUG: Erythromycin|DRUG: Doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Safety and Efficacy Study of Intravenous 131I-TM601 in Adult Patients With Malignant Melanoma
Status: TERMINATED
Conditions: Melanoma|Malignant Melanoma|Metastatic Melanoma
Interventions: DRUG: 131I-TM601
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study About Simvastatin in Portal Hypertension in Compensated Cirrhosis
Status: UNKNOWN
Conditions: Portal Hypertension.|Liver Cirrhosis
Interventions: DRUG: Simvastatin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy Study of Femoral Nerve Block in Children With a Femur Fracture
Status: TERMINATED
Conditions: Femoral Fractures|Pain, Postoperative
Interventions: DRUG: Marcaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implication of Left veNtricle Vortex Flow Guided aNticOagulation Therapy for preVenting Apical Thrombus Formation In Patients With Acute myOcardial infarctioN: Multicenter Prospective Randomized Clinical Trial; INNOVATION Study
Status: COMPLETED
Conditions: Apical Thrombus Formation|Acute Myocardial Infarction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Safety and Tolerability of A8G6 COVID-19 Neutralization Antibody Combined With Nasal Spray
Status: RECRUITING
Conditions: SARS-CoV-2|Prevention
Interventions: BIOLOGICAL: A8G6 SARS-CoV-2 Neutralization Antibody combination nasal spray|OTHER: A8G6 SARS-CoV-2 Neutralization Antibody nasal excipient
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostics of Clinical Hyperandrogenism
Status: RECRUITING
Conditions: Anovulation|PCOS
Interventions: DIAGNOSTIC_TEST: Assessment of the severity of hirsutism using the visual modified Ferriman-Gallwey scale|DIAGNOSTIC_TEST: Assessment of the severity of endogenetic alopecia using the visual Ludwig Scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acute Comfort and Blur Profile of a Lubricant Eye Drop Versus a Marketed Eye Ointment
Status: COMPLETED
Conditions: Dry Eye
Interventions: OTHER: Lubricant eye drop FID 115958D|OTHER: Refresh PM Ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Effects of Multiple Doses of Nilotinib on the Pharmacokinetics and Metabolism of Midazolam in CML Patients With Additional Extension Phase to Evaluate the Safety of Nilotinib
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Tasigna
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prevention of Eating Disorders Through Optimization of Protective Factors
Status: RECRUITING
Conditions: Body Dissatisfaction|Eating Disorders
Interventions: BEHAVIORAL: Enhancing protective factors|BEHAVIORAL: Expressive writing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Impact of Salpingectomy and Single Dose Systemic Methotrexate Treatments on Ovarian Reserve in Ectopic Pregnancy
Status: COMPLETED
Conditions: Ectopic Pregnancy|Infertility
Interventions: DRUG: Methotrexate|PROCEDURE: salpingectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Investigation of the Causes of Hepatic Dysfunction in the Postoperative Period During Open-heart Surgeries
Status: COMPLETED
Conditions: Hyperbilirubinemia|Hepatic Impairment|Surgery|Cardiac Disease
Interventions: PROCEDURE: Open-Heart Surgery for nine months duration|OTHER: Relation between possible risk factors and hyperbilirubinemia|OTHER: Follow-up period
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sleep Study-Guided Multidisciplinary Therapy for Patients Presenting With Acute Coronary Syndrome
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea|Acute Coronary Syndrome
Interventions: DEVICE: Continuous Positive Airway Therapy|BEHAVIORAL: Sleep-Study Guided Multidisciplinary Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Anti-Inflammatory Efficacy of Preemptive Dexamethasone and Etoricoxib
Status: UNKNOWN
Conditions: Effect of Drug
Interventions: DRUG: Dexamethasone|DRUG: Etoricoxib 60 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Nissen Fundoplication Comparing Division Versus Non-Division of Short Gastric Vessels
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: PROCEDURE: Lap Nissen fundoplication with division of short gastric vessels|PROCEDURE: Laparoscopic Nissen fundoplication without division of short gastric vessels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Nabilone for Agitation in Frontotemporal Dementia
Status: ACTIVE_NOT_RECRUITING
Conditions: Frontotemporal Dementia|Frontotemporal Dementia, Behavioral Variant|Primary Progressive Aphasia|bvFTD|PPA|FTD
Interventions: DRUG: Nabilone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Nicotinamide Plus Cream for Moderate Acne Vulgaris in Indonesia
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Adapalene|DRUG: Nicotinamide, ABA and Zinc PCA|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of Recombinant Human Serum Albumin/Interferon alpha2b Fusion Protein in Hepatitis B Patient
Status: COMPLETED
Conditions: Hepatitis B Virus
Interventions: BIOLOGICAL: Human Serum Albumin/interferon alpha2b fusion protein|BIOLOGICAL: Pegasys
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of HR091506 Tablets in Treatment of Primary Gout With Hyperuricemia in Adults
Status: UNKNOWN
Conditions: Primary Gout With Hyperuricemia in Adults
Interventions: DRUG: HR091506 tablets + placebo of febuxostat tablets|DRUG: febuxostat tablets + placebo of HR091506 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone in Patients With Newly-Diagnosed Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: Dexamethasone|DRUG: Lenalidomide|DRUG: Acetaminophen|DRUG: Diphenhydramine|DRUG: Montelukast|DRUG: Carfilzomib|DRUG: Daratumumab|BIOLOGICAL: Autologous Stem Cell Transplant (ASCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carfilzomib, Rituximab, Ifosfamide, Carboplatin, and Etoposide in Treating Patients With Relapsed or Refractory Stage I-IV Diffuse Large B-cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: CD20 Positive|Recurrent Diffuse Large B-Cell Lymphoma|Refractory Diffuse Large B-Cell Lymphoma|Stage I Diffuse Large B-Cell Lymphoma|Stage II Diffuse Large B-Cell Lymphoma|Stage III Diffuse Large B-Cell Lymphoma|Stage IV Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Carboplatin|DRUG: Carfilzomib|DRUG: Etoposide|DRUG: Ifosfamide|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of HYDEAL-D Vaginal Pessaries Application on the Treatment of Vaginal Atrophy in Post-menopause Women
Status: COMPLETED
Conditions: Vulvovaginal Atrophy
Interventions: DEVICE: Hydeal-D vaginal pessaries
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Adductor Canal Infusion vs. Single-injection Adductor Canal Block for Total Knee Arthroplasty
Status: RECRUITING
Conditions: Arthroplasty, Replacement, Knee|Pain, Postoperative|Multimodal Analgesia
Interventions: BEHAVIORAL: Pain scores (numerical rating scale at rest and motion): will be assessed with numerical rating scale at both rest and motion on both knees.|OTHER: Brief Pain Inventory (Short Form), WOMAC Osteoarthritis index, and Lower extremity functional scale|BEHAVIORAL: Rehabilitation physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Provide RoActemra/Actemra (Tocilzumab) to Patients With Multicentric Castleman's Disease Who Demonstrated Benefit From Previous RoActemra/Actemra Treatment
Status: COMPLETED
Conditions: Castleman's Disease
Interventions: DRUG: tocilizumab [RoActemra/Actemra]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of FYU-981 in Hyperuricemia (Effect on Two Hyperuricemic Types)
Status: COMPLETED
Conditions: Hyperuricemia
Interventions: DRUG: FYU-981|DRUG: Topiroxostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Topiramate for Cryptogenic Sensory Peripheral Neuropathy in Metabolic Syndrome (CSPN)
Status: COMPLETED
Conditions: Cryptogenic Sensory Peripheral Neuropathy in Metabolic Syndrome
Interventions: DRUG: topiramate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single-layer Robot-assisted Transperitoneal Retroperitoneal Tubeless Radical Nephrectomy
Status: RECRUITING
Conditions: Nonfunctional Kidney|Renal Cancer
Interventions: PROCEDURE: Single-layer robot-assisted transperitoneal retroperitoneal tubeless radical nephrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Patients With Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Non Hodgkin Lymphoma
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Targeted Zinc Fortification Programs on Plasma Zinc Concentration
Status: COMPLETED
Conditions: Zinc Deficiency
Interventions: DIETARY_SUPPLEMENT: Zinc fortified food|DIETARY_SUPPLEMENT: Zinc supplement|OTHER: Placebo supplement|DIETARY_SUPPLEMENT: Non-fortified food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of MCI-196 in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: MCI-196|DRUG: Placebo of MCI-196 Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effectiveness of Sertraline in Treating Women With Premenstrual Dysphoric Disorder
Status: COMPLETED
Conditions: Premenstrual Dysphoric Disorder
Interventions: DRUG: Sertraline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing - Robotic Assisted Versus Laparoscopic Partial Nephrectomy For Small Renal Masses
Status: UNKNOWN
Conditions: Small Renal Masses
Interventions: PROCEDURE: Robotic Assisted Nephrectomy|PROCEDURE: Laparoscopic Assisted Nephrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Percutaneous HydroDiscectomy Compared to TESI for Radiculopathy
Status: TERMINATED
Conditions: Lumbar Herniated Disc
Interventions: PROCEDURE: Percutaneous Hydrodiscectomy|DRUG: TESI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decitabine With or Without Interferon Alfa-2b in Treating Patients With Unresectable or Metastatic Solid Tumors
Status: TERMINATED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: peginterferon alfa-2b|DRUG: decitabine|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Concurrent and Aerobic Exercise on VO2max, Strength, and Body Composition in Overweight and Obese Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BEHAVIORAL: Concurrent exercise|BEHAVIORAL: Aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Xanthophylls on Optical Density
Status: COMPLETED
Conditions: Age-Related Macular Degeneration
Interventions: DIETARY_SUPPLEMENT: Verum|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Long-Term Safety of Ragweed (Ambrosia Artemisiifolia) Sublingual Tablet in Adults With a History of Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (Study P05233)(COMPLETED)
Status: COMPLETED
Conditions: Rhinitis; Allergic, With Asthma|Conjunctivitis
Interventions: BIOLOGICAL: SCH 39641 6 Amb a 1-U|BIOLOGICAL: SCH 39641 12 Amb a 1-U|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With Synucleinopathies
Status: UNKNOWN
Conditions: Parkinson Disease|Multiple System Atrophy|Rapid Eye Movement Sleep Behavior Disorder|Normal Pressure Hydrocephalus
Interventions: OTHER: Biomarker assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Anti-tumor Effect of Metformin And Atorvastatin in Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer Female
Interventions: DRUG: Placebo, metformin and atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Placebo Controlled, Dose Escalation Study in Subjects With Type 2 Diabetes Mellitus Being Treated With Sulfonylurea
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: ISIS 113715
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Impact of Fatty Acids From Seal Oil on the Relief of Symptoms Associated With Rheumatoid Arthritis
Status: RECRUITING
Conditions: Polyarthritis
Interventions: DIETARY_SUPPLEMENT: Seal oil|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Rivoglitazone in Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Pioglitazone|DRUG: Placebo|DRUG: Rivoglitazone|DRUG: Rivoglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Telerehabilitation-Based Interventions on the Musculoskeletal System in Drivers
Status: NOT_YET_RECRUITING
Conditions: Drive|Musculoskeletal Diseases|Postural; Defect
Interventions: OTHER: Telerehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quetiapine Versus Haloperidol in the Management of Hyperactive Delirium
Status: COMPLETED
Conditions: Hyperactive Delirium
Interventions: DRUG: Quatiapine|DRUG: Haloperidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin Deficiency
Status: COMPLETED
Conditions: Alpha-1 Antitrypsin Deficiency (AATD)|Pi*ZZ, Pi*SZ, Pi*Null, Another Rare Phenotype/Genotype Known to be Associated With Either Low or Functionally Impaired AAT Including F or I Mutations|Emphysema or COPD
Interventions: DRUG: Alvelestat (MPH966)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Programming Strategy of VFS for Gait Impairments in PD
Status: RECRUITING
Conditions: Parkinson's Disease|Deep Brain Stimulation|Gait Disorders, Neurologic
Interventions: DEVICE: Programming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Mineral Trioxide Aggregate in the Treatment of Traumatized Teeth
Status: COMPLETED
Conditions: Periapical Diseases
Interventions: DEVICE: ProRoot MTA|DEVICE: MTA+ Cerkamed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acceptability, Tolerance, Satiety and Prebiotic Effect of a New Infant Cereal
Status: COMPLETED
Conditions: Infant Nutrition Sciences
Interventions: DIETARY_SUPPLEMENT: New Infant Cereal|DIETARY_SUPPLEMENT: Multicereals Infant Cereal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjunctive SPD489 to Antipsychotic Medication in Clinically Stable Adults With Persistent Predominant Negative Symptoms of Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: SPD489 40mg|DRUG: SPD489 100mg|DRUG: SPD489 160mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Changes in Serum 25(OH)D Concentrations Following Vitamin D Supplementation With Chewable Tablets Versus Pills
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DRUG: Vitamin D chewable tablet supplementation|DRUG: Vitamin D pill supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Pharmacokinetics, Pharmacodynamics and Assess the Efficacy and Safety to Support Dose Selection of Emapalumab in Pre-empting Graft Failure in Patients at High Risk After HSCT.
Status: TERMINATED
Conditions: Graft Failure
Interventions: DRUG: Emapalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Outpatient Labor Induction With the Transcervical Foley Balloon
Status: UNKNOWN
Conditions: Pregnancy|Labor; Forced or Induced, Affecting Fetus or Newborn
Interventions: DEVICE: inpatient Foley balloon induction|DEVICE: outpatient Foley balloon induction|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Pharmacokinetic Study of New Nicotine Lozenge Formulations
Status: COMPLETED
Conditions: Healthy Smokers
Interventions: DRUG: V0474 - A mg|DRUG: V0474 - B mg|DRUG: V0474 - C mg|DRUG: V0018 - B mg|DRUG: Niquitin® Fresh Mint 4 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Metabolic Bone Disease of Prematurity Using an Acoustic Method
Status: ENROLLING_BY_INVITATION
Conditions: Metabolic Bone Disease|Osteopenia|Neonatal Rickets
Interventions: DIAGNOSTIC_TEST: Vibro-acoustic analysis (VAA), based on ultrasound radiation force
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Clinical Study to Assess the Efficacy and Safety of Gene Therapy for the Treatment of Cerebral Adrenoleukodystrophy (CALD)
Status: COMPLETED
Conditions: Cerebral Adrenoleukodystrophy (CALD)
Interventions: GENETIC: Lenti-D
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Full Pulpotomy Versus Root Canal Treatment for Teeth With Symptomatic Irreversible Pulpitis
Status: RECRUITING
Conditions: Pulpitis - Irreversible
Interventions: PROCEDURE: Root canal treatment (Control)|PROCEDURE: Full pulpotomy (Experimental)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Korean Medicine Treatment for Cervical Disc Herniation
Status: ACTIVE_NOT_RECRUITING
Conditions: Neck Pain|Cervical Radiculopathy|Intervertebral Disc Displacement
Interventions: DRUG: Herbal medicine|PROCEDURE: Chuna manual medicine|PROCEDURE: Bee venom pharmacopuncture|PROCEDURE: Pharmacopuncture|PROCEDURE: Acupuncture|PROCEDURE: Electroacupuncture|PROCEDURE: Cupping|PROCEDURE: Other intervention(s)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of AsiDNATM, a DNA Repair Inhibitor, Administered Intravenously in Addition to PARP Inhibitors in Patients With Relapsed Platinum Sensitive Ovarian Cancer Already Treated With PARP Inhibitors Since at Least 6 Months
Status: RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: AsiDNA|DRUG: Niraparib|DRUG: Olaparib|DRUG: Rucaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy
Status: COMPLETED
Conditions: Ivermectin|Onchocerciasis|Epilepsy
Interventions: DRUG: Ivermectin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Osimertinib With or Without Bevacizumab for EGFR- Mutant Non-small Cell Lung Cancer With Leptomeningeal Metastasis
Status: UNKNOWN
Conditions: Leptomeningeal Metastasis|Non-small Cell Lung Cancer|EGFR Activating Mutation
Interventions: DRUG: Osimertinib|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Amlodipine Besylate/Benazepril HCl 10 mg/40 mg Capsules of Dr. Reddy's Under Fed Conditions
Status: COMPLETED
Conditions: Fed
Interventions: DRUG: Amlodipine Besylate/Benazepril HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACCENT: AMP945 in Combination With Nab-paclitaxel and Gemcitabine for Treatment of Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer|PDAC|Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: AMP945 ascending doses|DRUG: AMP945 RP2D
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Angioedema Biomarker Research Study
Status: NOT_YET_RECRUITING
Conditions: Angioedema|Angioedemas, Hereditary|Urticaria|Mastocytosis|ACE Inhibitor-Induced Angioedema|C1 Inhibitor Deficiency|Systemic Mastocytoses|Indolent Systemic Mastocytosis
Interventions: DIAGNOSTIC_TEST: Venipuncture
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Stimulant Oxytocin Study
Status: COMPLETED
Conditions: Stimulant Use & Co-occuring Opioid Use Disorders
Interventions: DRUG: Intranasal oxytocin|DRUG: Intranasal placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Synbiotic Compound to Reduce Symptoms of Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: BIOLOGICAL: Synbiotic Supplement|BIOLOGICAL: Inert Compound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pembrolizumab (MK-3475) Versus Paclitaxel for Participants With Advanced Gastric/Gastroesophageal Junction Adenocarcinoma That Progressed After Therapy With Platinum and Fluoropyrimidine (MK-3475-061/KEYNOTE-061)
Status: COMPLETED
Conditions: Gastric Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma
Interventions: BIOLOGICAL: pembrolizumab|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SMILES: Study of Montelukast in Sickle Cell Disease
Status: RECRUITING
Conditions: Anemia, Sickle Cell|Sleep-Disordered Breathing
Interventions: DRUG: Montelukast|OTHER: Oral Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peroperative Fluid Management in Major Gynecological Cancer Surgeries
Status: COMPLETED
Conditions: Fluid Overload|Fluid Loss|Perioperative/Postoperative Complications|Acute Kidney Injury
Interventions: DIAGNOSTIC_TEST: Akut kidnet injury(AKI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Monosialotetrahexosylganglioside for Treatment of Oxaliplatin Induced Neurotoxicity in Gastrointestinal Cancer
Status: COMPLETED
Conditions: Neurotoxicity
Interventions: DRUG: placebo|DRUG: GM|DRUG: oxaliplatin-based chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies
Status: RECRUITING
Conditions: Postoperative Delirium|Hemodynamic Instability|Pain|Neurocognitive Dysfunction
Interventions: DEVICE: EEG Monitoring|DRUG: Ropivacaine|DRUG: Ketamine|DRUG: Remifentanil|DRUG: Dexmedetomidine|DRUG: Rocuronium|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19)
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Respiratory Distress Syndrome|ARDS (Moderate or Severe)|COVID-19 Pneumonia
Interventions: BIOLOGICAL: Mesenchymal stromal cells|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immediate Effects of Superficial Heat Associated With Elongation in the Posttraumatic Elbow Contracture
Status: COMPLETED
Conditions: Contracture of Elbow Joint
Interventions: OTHER: Modified Weeks protocol|OTHER: CIVM|OTHER: GC- Sustained Stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Placing Bravo PH Capsule in Proximal Esophagus
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DEVICE: BRAVO capsule|PROCEDURE: Fluoroscopy|OTHER: sham BRAVO capsule placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of JK07 in Patients With Chronic Heart Failure
Status: RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction|Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: JK07|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Electroacupuncture for Chemotherapy-Related Cognitive Impairment
Status: NOT_YET_RECRUITING
Conditions: Chemotherapy-Related Cognitive Impairment
Interventions: DEVICE: Electroacupuncture|DEVICE: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Evaluation of Two Toric Contact Lenses in Current Non-toric Lens Users
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: Senofilcon A Toric (AOfA)|DEVICE: Etafilcon A Toric (1DAMfA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test How a New Long-acting Insulin (Insulin Icodec) Works in the Body of People From China With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: insulin icodec
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Cold Biopsy Forceps Versus Cold Snare Biopsy for Colon Polyps
Status: COMPLETED
Conditions: Colon Polyps
Interventions: PROCEDURE: Cold Biopsy forceps|PROCEDURE: Cold snare biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy and Safety of Vardenafil in Patients With Erectile Dysfunction and Type 1 Diabetes
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Levitra (Vardenafil, BAY38-9456)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MM-111 in Patients With Advanced, Refractory Her2 Amplified, Heregulin Positive Cancers
Status: COMPLETED
Conditions: Her2 Amplified Solid Tumors|Metastatic Breast Cancer
Interventions: DRUG: MM-111
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT