pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: High Dose Rifapentine Pharmacokinetics, Tolerability and Safety Dosage Rifapentine for Treatment of Tuberculosis
Status: COMPLETED
Conditions: Smear Positive, Pan-sensitive, Pulmonary Tuberculosis
Interventions: DRUG: Rifapentine|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Immunogenicity and Vaccine-like Viral Shedding of MEDI-534, Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3), in Healthy 6 to <24 Month-old Children and in 2 Month-old Infants
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: MEDI-534, Cohort 1|OTHER: Placebo, Cohort 1|BIOLOGICAL: MEDI-534, Cohort 2|OTHER: Placebo, Cohort 2|BIOLOGICAL: MEDI-534, Cohort 3|OTHER: Placebo, Cohort 3|BIOLOGICAL: MEDI-534, Cohort 4|OTHER: Placebo, Cohort 4|BIOLOGICAL: MEDI-534, Cohort 5|OTHER: Placebo, Cohort 5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trametinib in Treating Patients With Epithelioid Hemangioendothelioma That is Metastatic, Locally Advanced, or Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Locally Advanced Epithelioid Hemangioendothelioma|Metastatic Epithelioid Hemangioendothelioma|Unresectable Epithelioid Hemangioendothelioma
Interventions: OTHER: Questionnaire Administration|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Low-Dose Whole Brain Radiotherapy With Concurrent Temozolomide and Adjuvant Temozolomide in Patients With Newly-Diagnosed Glioblastoma Multiforme
Status: TERMINATED
Conditions: Histologically Proven Diagnosis of Glioblastoma or Gliosarcoma (WHO Grade IV)
Interventions: DRUG: Chemotherapy with Temodar.|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of VAY736 in Patients With Pemphigus Vulgaris
Status: TERMINATED
Conditions: Pemphigus Vulgaris
Interventions: DRUG: VAY736|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Choline Magnesium Trisalicylate and Combination Chemotherapy in Treating Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Recurrent Adult Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: choline magnesium trisalicylate|DRUG: idarubicin|DRUG: cytarabine|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Varenicline and Motivational Advice for Smokers With Substance Use Disorders
Status: COMPLETED
Conditions: Smoking Cessation|Nicotine Dependence
Interventions: DRUG: Nicotine Replacement Treatment (NRT)|DRUG: varenicline|BEHAVIORAL: Behavioral counseling for smoking cessation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cold Knife Conization With and Without Lateral Hemostatic Sutures
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia|Cervix Neoplasms
Interventions: PROCEDURE: Cold Knife Conization with stitches|PROCEDURE: Cold knife Conization without stitches
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety and Immunogenicity of the SF2a-TT15 Synthetic Carbohydrate-based Conjugate Vaccine Against Shigella Flexneri 2a
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Injection SF2A-TT15 10 µg Adjuvanted|BIOLOGICAL: Injection SF2A-TT15 10 µg|BIOLOGICAL: Injection Adjuvanted Placebo|BIOLOGICAL: Injection Placebo|BIOLOGICAL: Injection SF2A-TT15 2 µg Adjuvanted|BIOLOGICAL: Injection SF2A-TT15 2 µg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Topical Naltrexone Ophthalmic Solution on the Signs and Symptoms of Dry Eye in Diabetic Subjects
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: Naltrexone|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of a Modified Ramadan Fasting on Health and Well-being in Healthy Muslims - a Randomised Controlled Trial
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BEHAVIORAL: Modified Ramadan Fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Tinengotinib VS. Physician's Choice a Treatment of Subjects With FGFR-altered in Cholangiocarcinoma
Status: RECRUITING
Conditions: Cholangiocarcinoma
Interventions: DRUG: Tinengotinib 8 mg|DRUG: Tinengotinib 10 mg|DRUG: Physician's Choice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Infusion of Paracetamol for Intrapartum Analgesia of Labor
Status: COMPLETED
Conditions: Labor Pain
Interventions: DRUG: (1) Paracetamol injection|OTHER: Sterile water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Safety and Efficacy of Repeat Doses of UB-621in Adult Patients With Recurrent Genital Herpes
Status: NOT_YET_RECRUITING
Conditions: Recurrent Genital Herpes
Interventions: OTHER: Placebo|BIOLOGICAL: UB-621 low-dose|BIOLOGICAL: UB-621 high-dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Physiological Versus Right Ventricular Outcome Trial Evaluated for Bradycardia Treatment Upgrades
Status: RECRUITING
Conditions: Pacing-Induced Cardiomyopathy|Heart Failure
Interventions: DEVICE: Physiological Pacing Upgrade (Conduction System Pacing or Biventricular Pacing)|DEVICE: Continued RV Pacing (Right Ventricular Pacing)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of MSTT1041A in Participants With Moderate to Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: MSTT1041A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of HMPL-453 Tartrate in Advanced Intrahepatic Cholangiocarcinoma
Status: RECRUITING
Conditions: Advanced Intrahepatic Cholangiocarcinoma
Interventions: DRUG: HMPL-453
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity of Hepatitis B Vaccination Among Drug Users
Status: COMPLETED
Conditions: Hepatitis B Vaccination
Interventions: BIOLOGICAL: 60 µg dose hepatitis B vaccine|BIOLOGICAL: 20 µg dose hepatitis B vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Different Surgical Modalities for Thigh Lipodystrophy Including Liposuction,Thigh Lift and Liposuction Assisted Thigh Lift
Status: UNKNOWN
Conditions: Thigh Lipodystrophy
Interventions: PROCEDURE: thigh lift
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ramelteon for a Nap Prior to a Night Shift
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ramelteon|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Omega 3 in Intervention Spinal Cord Injured People
Status: COMPLETED
Conditions: Lipid Metabolism Disorders|Peroxidase; Defect
Interventions: DIETARY_SUPPLEMENT: w3 supplement in SCI|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 3D Comparison of Anterior Teeth Retraction and Anchorage Control Between En-masse and Two-step Mechanics
Status: UNKNOWN
Conditions: Malocclusion, Angle Class I|Bimaxillary Protrusion|Orthodontic Space Closure
Interventions: PROCEDURE: En masse anterior teeth retraction|PROCEDURE: Two-Step Retraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Value of MRI in the Characterization of Ovarian Masses Unable to Classify With Ultrasound Using the International Ovarian Tumor Analysis (IOTA) Simple Rules
Status: UNKNOWN
Conditions: Patients With a Sonographically Unclassifiable Adnexal Mass Using the IOTA Simple Rules
Interventions: OTHER: Diffusion/Perfusion-weighted Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immunogenicity & Safety Study of GSK Biologicals' 208136 Vaccine Formulated With New Measles and Rubella Working Seeds
Status: COMPLETED
Conditions: Measles|Varicella|Mumps|Rubella
Interventions: BIOLOGICAL: Priorix-Tetra (combined measles-mumps-rubella-varicella vaccine)|BIOLOGICAL: GSK Biologicals' 208136, new formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Computer-Delivered PFI for Anxiety Sensitivity/Alcohol Intervention for Hazardous Drinkers With Elevated Anxiety Sensitivity
Status: COMPLETED
Conditions: Alcohol Drinking|Anxiety|Coping Behavior
Interventions: BEHAVIORAL: Personalized feedback intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Positive Pressure Ventilation Through a Laryngeal Mask Airway in Pediatrics
Status: COMPLETED
Conditions: Pediatric|Anesthesia
Interventions: DEVICE: Orotracheally intubation|DEVICE: Laryngeal Mask Airway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anticancer Treatment of Breast Cancer Related to Cardiotoxicity and Dysfunctional Endothelium
Status: COMPLETED
Conditions: Breast Neoplasms|Endothelial Dysfunction|Cardiovascular Disease|Metabolic Syndrome
Interventions: PROCEDURE: Venous occlusion plethysmography|PROCEDURE: SphygmoCor|PROCEDURE: 24hour blood pressure|PROCEDURE: DEXA scan|BIOLOGICAL: Laboratory blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dignity Talk: Helping Palliative Care Patients and Families Have Important Conversations
Status: COMPLETED
Conditions: Palliative Care|Family|End of Life Care
Interventions: BEHAVIORAL: Dignity Talk|BEHAVIORAL: The Dignity Talk Communication Topics
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Do Mind Ease Interventions Reduce Feelings of Acute Anxiety? A Randomised Controlled Trial
Status: RECRUITING
Conditions: Anxiety
Interventions: OTHER: intervention with this name in MindEase app|OTHER: reading about anxiety
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Providing an Optimized and Empowered Pregnancy for You (POPPY) Aim 3: Randomized Controlled Trial
Status: RECRUITING
Conditions: Pregnancy Complications|Maternal Distress|Adverse Birth Outcomes|Infant Conditions
Interventions: BEHAVIORAL: Digital Health intervention|BEHAVIORAL: Community Health Worker|BEHAVIORAL: Digital Health Intervention plus Community Health Worker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Fluoxetine vs CBT in Childhood Anxiety Disorders
Status: ACTIVE_NOT_RECRUITING
Conditions: Anxiety Disorders
Interventions: DRUG: Fluoxetine|BEHAVIORAL: Cognitive Behavioral Therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Pharmacokinetics And Pharmacodynamics of Intravenously Administered Pegasys (Peginterferon Alfa-2a) in Patients With Chronic Hepatitis C And Previous Non-Response to Pegylated Interferon And Ribavirin Combination Therapy
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: peginterferon alfa 2a [Pegasys]|DRUG: peginterferon alfa-2a [Pegasys]|DRUG: peginterferon alfa-2a [Pegasys]|DRUG: peginterferon alfa-2a [Pegasys]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Ultrasound Evaluation of the Common Bile Duct in Patients With Obstructive Jaundice Due to Bilio-pancreatic Malignancies (ECCO Trial)
Status: COMPLETED
Conditions: Obstructive Jaundice|Bilio-pancreatic Tumor
Interventions: PROCEDURE: Ultrasound endoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Theta-Burst Transcranial Magnetic Stimulation (TBS) for Freezing of Gait
Status: RECRUITING
Conditions: Transcranial Magnetic Stimulation|Freezing of Gait
Interventions: DEVICE: Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Nivolumab (BMS-936558) in Patients With Advanced or Metastatic Squamous Cell Nonsmall-cell Lung Cancer Who Have Received At Least 2 Prior Systemic Regimens
Status: COMPLETED
Conditions: Squamous Cell Non-small Cell Lung Cancer
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Educational Program to Improve Cardiac Arrest Diagnostic Accuracy of Ambulance Telecommunicators
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Arrest|Heart Arrest, Out-Of-Hospital|Cardiac Arrest|Death, Sudden, Cardiac|Cardiac Arrest, Sudden|Cardiopulmonary Arrest
Interventions: OTHER: Educational Intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pirfenidone Effect on the Recovery of Renal Function in Septic Acute Kidney Injury
Status: UNKNOWN
Conditions: Acute Kidney Injury|Sepsis
Interventions: DRUG: Pirfenidone extended release|DRUG: Placebo equivalent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Denintuzumab Mafodotin (SGN-CD19A) Combined With RCHOP or RCHP Versus RCHOP Alone in Diffuse Large B-Cell Lymphoma or Follicular Lymphoma
Status: TERMINATED
Conditions: Diffuse, Large B-Cell, Lymphoma|Follicular Lymphoma, Grade 3b|Transformed Lymphoma / DLBCL
Interventions: DRUG: denintuzumab mafodotin|DRUG: rituximab|DRUG: cyclophosphamide|DRUG: doxorubicin|DRUG: vincristine|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Active Close Contact Investigation of Tuberculosis Through Computer-aided Detection and Stool Xpert MTB/RIF Among People Living in Ethiopia
Status: NOT_YET_RECRUITING
Conditions: Diagnosis|Tuberculosis|geneXpert
Interventions: DIAGNOSTIC_TEST: Diagnosis of Tuberculosis with computer-aided detection (CAD) software
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of Keeping the Patient in a Sitting Position for One Minute After Spinal Anesthesia
Status: COMPLETED
Conditions: Hypotension|Spinal Anaesthesia
Interventions: PROCEDURE: sitting position|PROCEDURE: supine position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Transcutaneous Tibial Nerve Stimulation for Spinal Cord Injury Neurogenic Bladder
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Variable-dose TTNS Protocol 5 x week|DEVICE: Fixed-dose TTNS Protocol|DEVICE: Variable-dose TTNS Protocol 2 x week
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TMS in Inflammatory Bowel Disease
Status: TERMINATED
Conditions: Inflammatory Bowel Diseases|Maladaptive Behavior Associated With Physical Illness
Interventions: DEVICE: iTBS repetitive Transcranial Magnetic Stimulation (rTMS)|DEVICE: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Treatment With Invasive Technique in Cancer Pain Management
Status: NOT_YET_RECRUITING
Conditions: Cancer Pain|Opioid Use
Interventions: PROCEDURE: Mini invasive analgesic technique|DRUG: high opioids dosages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Efficacy and Safety of Different Doses of Nifekalant Instant Cardioversion of Persistent Atrial Fibrillation During Radiofrequency Ablation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DRUG: nifekalant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Delivery Optimization for Pre-Exposure Prophylaxis (DO PrEP) Study
Status: RECRUITING
Conditions: HIV|Human Immunodeficiency Virus|ART
Interventions: OTHER: HIV PrEP Delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pirfenidone to Treat Kidney Disease (Focal Segmental Glomerulosclerosis)
Status: COMPLETED
Conditions: Fibrosis|Focal Glomerulosclerosis|Kidney Failure|Nephrotic Syndrome|Proteinuria
Interventions: DRUG: Pirfenidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of PET/CT to Detect the Oral/Pulmonary Distribution of Nicotine Following E-cigarette Use
Status: ACTIVE_NOT_RECRUITING
Conditions: E-cigarette Use
Interventions: DRUG: C-11 labeled nicotine|RADIATION: PET/CT imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Specific Lung Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients in Supine and Prone Position
Status: COMPLETED
Conditions: Acute Lung Injury|Acute Respiratory Distress Syndrome
Interventions: PROCEDURE: specific elastance
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Open-label Study Evaluating the Pharmacokinetics and Drug-drug Interaction of VX-993 in Healthy Adults
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: VX-993|DRUG: Gemfibrozil|DRUG: Itraconazole|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease
Status: COMPLETED
Conditions: Moderate Risk of CVD
Interventions: DRUG: Aspirin (Acetylsalicylic acid, BAYE4465)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mobile Health Application of Screening and Early Intervention for Prediabetic Patient at Primary Health Cares Setting
Status: UNKNOWN
Conditions: PreDiabetes|Prediabetic State
Interventions: DEVICE: Mobile health apps|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: Effect of Polyphenol Extract on Cardiovascular Health Markers: a 4 Way Randomised Crossover Study
Status: UNKNOWN
Conditions: Cardiovascular Diseases|Endothelial Dysfunction|Blood Pressure
Interventions: DIETARY_SUPPLEMENT: Polyphenol extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare SB16 (Proposed Denosumab Biosimilar) to Prolia® in Postmenopausal Women With Osteoporosis
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: SB16 (Proposed Denosumab Biosimilar)|DRUG: Prolia® (Denosumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors
Status: UNKNOWN
Conditions: Low Grade Gliomas|Craniopharyngioma|Ependymomas|Meningiomas
Interventions: RADIATION: Stereotactic Conformal radiotherapy|RADIATION: Conventional radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Couples' Intervention Protocol for PTSD
Status: RECRUITING
Conditions: Psychological Trauma
Interventions: BEHAVIORAL: CBCT for PTSD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PK Sub-Study of QUILT-3.032 (CA ALT-803-01-16) and of QUILT-2.005 (CA ALT-803-01-14)
Status: TERMINATED
Conditions: Pharmacokinetics
Interventions: BIOLOGICAL: BCG in Combination with N-803|DRUG: N-803 alone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lab Evaluation of Novel Hearing Aid Coupling Method
Status: RECRUITING
Conditions: Hearing Loss
Interventions: DEVICE: Recordings of Hearing Aids with Open Domes|DEVICE: Recordings of Hearing Aids with Closed Domes|DEVICE: Recordings of Hearing Aids with Novel State 1|DEVICE: Recordings of Hearing Aids with Novel State 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib Before Donor Stem Cell Transplant in Treating Patients With Multiple Myeloma
Status: WITHDRAWN
Conditions: Multiple Myeloma|Refractory Multiple Myeloma
Interventions: PROCEDURE: nonmyeloablative allogeneic hematopoietic stem cell transplantation|PROCEDURE: allogeneic bone marrow transplantation|DRUG: bortezomib|DRUG: melphalan|DRUG: anti-thymocyte globulin|DRUG: sirolimus|DRUG: tacrolimus|RADIATION: total-body irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare Outcomes Between Two Acellular Dermal Matrices
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: Alloderm RTU|OTHER: Cortiva 1mm Allograft Dermis|PROCEDURE: Skin or nipple-sparing mastectomy|OTHER: Breast Q|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of the Efficacy and Safety of Remimazolam in General Anesthesia in Adults Undergoing Cardiac Surgery
Status: TERMINATED
Conditions: Anesthesia
Interventions: DRUG: Propofol|DRUG: Remimazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Hypoglycemia Prevention After Exercise in Adolescent T1DM Patients Using a Control to Range System
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Open-Loop|DEVICE: Closed-Loop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prophylactic Antibiotics or Placebo After Hypospadias Repair
Status: UNKNOWN
Conditions: Hypospadias
Interventions: DRUG: trimethoprim-sulfamethoxazole|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Use of a Novel Fibrin Sealant in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis|Intraoperative Bleeding
Interventions: DRUG: Evicel Fibrin Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: FitEx for Endometrial Cancer Survivors
Status: COMPLETED
Conditions: Quality of Life|Cancer of Endometrium|Behavior, Health|Self Efficacy
Interventions: BEHAVIORAL: FitEx|BEHAVIORAL: Weekly Yoga Sessions|BEHAVIORAL: Weekly Movement Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Barrier Products in the Prevention of Incontinence-associated Dermatitis in Hospitalized Elderly
Status: COMPLETED
Conditions: Diaper Rash
Interventions: DEVICE: water and soap|DEVICE: zinc oxide|DEVICE: Non-Irritant Barrier Film
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Extension Study of the Safety and Efficacy of Enteric-coated Mycophenolate Sodium in Kidney Transplant Recipients
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: Enteric-Coated Mycophenolate Sodium (EC-MPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Feasibility of the NEXT Steps Weight Loss Intervention +/- Resistance Training for Endometrial Cancer Survivors: Effect on Lean Mass & Biomarkers
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Neoplasms of Female Genital Organs
Interventions: DEVICE: Accelerometer|BEHAVIORAL: Questionnaires|BEHAVIORAL: Fitness Test|BEHAVIORAL: Resistance Training|BEHAVIORAL: Aerobic Exercise|BEHAVIORAL: Telephone Coaching/Phone Calls|BEHAVIORAL: Video Chat Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Exploring Physical Exercise for the Regulation and Control of Metabolic Disorders in College Students.
Status: NOT_YET_RECRUITING
Conditions: Metabolic Disorders|Abdominal Obesity|Blood Pressure Disorders|Hypertriglyceridemia|Hyperglycemia|HDL-Deficiency
Interventions: BEHAVIORAL: Physical exercise prescription: Continuous aerobic training (jogging, swimming, static cycling)|BEHAVIORAL: Control group: Continuous aerobic physical exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Efficacy and Safety of DSXS in Patients With Mild to Moderate Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: DSXS|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ABX464 in Subjects With Moderate to Severe Active Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: ABX464|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cisplatin Plus Vinorelbine With or Without Tirapazamine in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: tirapazamine|DRUG: vinorelbine tartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Steroids on Thrombosis (Blood Clot Formation) and Inflammation in Patients Undergoing Hip Surgery
Status: COMPLETED
Conditions: Total Hip Replacement
Interventions: DRUG: Prednisone|DRUG: Hydrocortisone|DRUG: Placebo (for Prednisone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Resilience-Based Rehabilitation Program for Patients With Coronary Heart Disease
Status: NOT_YET_RECRUITING
Conditions: Takotsubo Cardiomyopathy|Acute Coronary Syndrome|Psychological Resilience
Interventions: OTHER: Resilience training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Health Literacy in Understanding Radiation Therapy Information in Patients Undergoing Definitive Radiation Therapy
Status: TERMINATED
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8|Stage I Prostate Cancer AJCC v8|Stage II Prostate Cancer AJCC v8|Stage IIA Prostate Cancer AJCC v8|Stage IIB Prostate Cancer AJCC v8|Stage IIC Prostate Cancer AJCC v8|Stage III Prostate Cancer AJCC v8|Stage IIIA Prostate Cancer AJCC v8|Stage IIIB Prostate Cancer AJCC v8|Stage IIIC Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8
Interventions: OTHER: Survey Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The ED95 of Single Intravenous Bolus Remimazolam Besylate in Pediatric Patients During General Anesthesia Induction
Status: RECRUITING
Conditions: Pediatric|ED95|Sedation|General Anesthesia
Interventions: DRUG: Remimazolam besylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Cognitive Functions, Psychological Symptoms, and Quality of Life Among B Thalassemia Patients and Their Clinical Correlates.
Status: UNKNOWN
Conditions: B Thalassemia
Interventions: DIAGNOSTIC_TEST: Wechsler IQ for Adults|DIAGNOSTIC_TEST: MAS (Memory assessment scale)|DIAGNOSTIC_TEST: Health-Related Quality of Life (HRQoL)|DIAGNOSTIC_TEST: Symptom check list 90|DIAGNOSTIC_TEST: Socioeconomic level
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Anti-HIV Drug Combinations to Prevent Mother-to-Child Transmission of HIV
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Abacavir sulfate, lamivudine, and zidovudine|DRUG: Lamivudine/zidovudine|DRUG: Lopinavir/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Reducing Socioeconomic Disparities in Health at Pediatric Visits
Status: COMPLETED
Conditions: Asthma|Obesity|Health Care Utilization|Health Care Disparities|Basic Unmet Social Needs|Blood Pressure|Child Maltreatment|Child Development
Interventions: BEHAVIORAL: WE CARE survey|BEHAVIORAL: WE CARE Community Resource Handout|BEHAVIORAL: Patient Navigator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: SWISH Trial (Strategies for Weaning Infants on Supportive High Flow)
Status: RECRUITING
Conditions: Respiratory Disease|Bronchiolitis, Viral|Infant Morbidity
Interventions: DEVICE: High flow nasal cannula support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn More About How Well Elinzanetant Works and How Safe it is for the Treatment of Vasomotor Symptoms (Hot Flashes) That Are Caused by Hormonal Changes Over 26 Weeks in Women Who Have Been Through the Menopause (OASIS-2)
Status: COMPLETED
Conditions: Vasomotor Symptoms Associated With Menopause|Hot Flashes
Interventions: DRUG: Elinzanetant (BAY3427080)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug Treatment Validation of Functional Magnetic Resonance Imaging in Generalized Anxiety Disorder
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: DRUG: Alprazolam (Xanax)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial to Assess Efficacy of Melatonin for Children During Burn Rehabilitation
Status: TERMINATED
Conditions: Burns
Interventions: DRUG: Melatonin|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Current Therapies for Chronic Neck Pain
Status: COMPLETED
Conditions: Chronic Neck Pain
Interventions: OTHER: Neck stabilization exercise|OTHER: TENS|OTHER: IFC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Influence of Preoperative Support on Anxiety, Pain and Satisfaction With Postoperative Analgesia
Status: COMPLETED
Conditions: Pain, Postoperative|Surgery, Thoracic
Interventions: BEHAVIORAL: Routine preoperative information from a nurse|BEHAVIORAL: Additional information support from a psychologist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gut Microbiome & Gastrointestinal Toxicities as Determinants of Response to Neoadjuvant Chemo for Advanced Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: OTHER: Blood & Fecal Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Results of the Tactys Implant in Proximal Interphalangeal Joint Arthroplasty
Status: UNKNOWN
Conditions: Interphalangeal; Osteoarthritis, Proximal (Bouchard)
Interventions: PROCEDURE: Proximal Interphalangeal Joint Arthroplasty with the Tactys Prosthesis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A New Spinal Orthosis for Adolescent Idiopathic Scoliosis
Status: UNKNOWN
Conditions: Scoliosis; Adolescence
Interventions: DEVICE: Spinal Orthosis with an Integrated System of Electric Surface Stimulation and Heat Sensing|DEVICE: spinal orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Pertubation on Pregnancy Rates Before Intrauterine Insemination Treatment
Status: COMPLETED
Conditions: Infertility|Pertubation|Insemination
Interventions: PROCEDURE: Pertubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioefficacy of Phenolic Acids
Status: COMPLETED
Conditions: Endothelial Dysfunction
Interventions: DIETARY_SUPPLEMENT: phenolic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent Exotropia
Status: TERMINATED
Conditions: Intermittent Exotropia
Interventions: DEVICE: CIAO therapy Amblyz glasses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alternating Systemic Chemotherapy and Intra-Arterial Melphalan (IAM) Chemotherapy in Children With Intra-Ocular Retinoblastoma
Status: TERMINATED
Conditions: Advanced Intra-Ocular Retinoblastoma|Retinoblastoma
Interventions: DRUG: Melphalan|DRUG: Carboplatin|DRUG: Etoposide|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between Smart Bur II and Traditional Carbide Bur in Selective Removal of Caries in Permanent Molars
Status: COMPLETED
Conditions: Dental Caries in Children
Interventions: DEVICE: caries removal by carbide bur|DEVICE: caries removal by polymer bur II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Research on Infarction With Open Arteries Using OCT and CMR
Status: ACTIVE_NOT_RECRUITING
Conditions: Myocardial Infarction
Interventions: DEVICE: OCT|PROCEDURE: CMR|DRUG: contrast agent, Gadolinium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the PK and PD of IM or SQ Injections of Levonorgestrel Butanoate (LB) for Female Contraception
Status: RECRUITING
Conditions: Healthy Women|Female Contraception
Interventions: BIOLOGICAL: levonorgestrel butanoate (LB) injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: To Evaluate the Safety and Efficacy of Preemptive Administration of Continuous Renal Replacement Therapy in Patients With Acute Liver Failure With Cerebral Edema
Status: UNKNOWN
Conditions: Acute Liver Failure
Interventions: PROCEDURE: Continuous Renal Replacement Therapy (CRRT)|OTHER: Standard Medical Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1 Esterase Inhibitor for the Prevention of Angioedema Attacks in Adolescents and Adults With Hereditary Angioedema
Status: COMPLETED
Conditions: Hereditary Angioedema (HAE)
Interventions: DRUG: C1 esterase inhibitor [human] liquid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Oxycodone/Naloxone(OXN), Versus Oxycodone (OXY), for the Reduction of Intensity of Opioid-induced Constipation in Pain Patients
Status: TERMINATED
Conditions: Constipation|Pain
Interventions: DRUG: Oxycodone Naloxone|DRUG: Oxycodone PR Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Patients With Locally Advanced or Metastatic Skin Cancer
Status: COMPLETED
Conditions: Recurrent Skin Carcinoma|Skin Squamous Cell Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microcomplications in Lap. Cholecystectomy: Reducing Intraoperative Interruptions by High Resolution Standardization
Status: COMPLETED
Conditions: Workflow|Costs|Laparoscopy|Cholecystectomy
Interventions: PROCEDURE: High resolution standardized laparoscopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Root Coverage With Acellular Dermal Matrix: Puros® Dermis Versus Alloderm®
Status: COMPLETED
Conditions: Gingival Recession
Interventions: DEVICE: Puros® Dermis versus Alloderm®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Armolipid Plus on Cholesterol Levels and Endothelial Function
Status: COMPLETED
Conditions: Hyperlipidemia|Endothelial Dysfunction
Interventions: DIETARY_SUPPLEMENT: Mixture of Berberine, Policosanol, Red Yeast, Placebo
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preemptive Lung Impedance-guided Therapy of Evolving Acute Heart Failure in Acute Myocardial Infarction Patients
Status: TERMINATED
Conditions: Acute Heart Failure
Interventions: DEVICE: Lung impedence-guided therapy|OTHER: Usual treatment of patients with developing acute heart failure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Potential Decrease in Hospitalization Events, Time Between Events, and Increasing Longevity in Patients With Symptomatic Heart Failure (0954-948)
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Losartan 50 mg|DRUG: Losartan 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Haploidentical Bone Marrow Transplantation in Sickle Cell Patients (BMTCTN1507)
Status: ACTIVE_NOT_RECRUITING
Conditions: Sickle Cell Disease
Interventions: PROCEDURE: Haploidentical Bone Marrow Transplantation|DRUG: Hydroxyurea|DRUG: Rabbit-ATG|DRUG: Thiotepa|DRUG: Fludarabine|DRUG: Cyclophosphamide|RADIATION: Total Body Irradiation|DRUG: Mesna
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spironolactone Therapy in Chronic Stable Right HF Trial
Status: COMPLETED
Conditions: Chronic Right-Sided Heart Failure|Pulmonary Arterial Hypertension|Pulmonary Hypertension, Primary, 2|Pulmonary Hypertension, Primary, 3|Pulmonary Hypertension, Primary, 4|Cardiomyopathy Right Ventricular
Interventions: DRUG: Spironolactone|DRUG: Placebo|RADIATION: PET/CT Scan: Two PET scans using 1. C-11 HED and 2. N-13 Ammonia or rubidium-82|DIAGNOSTIC_TEST: Cardiac MRI (Gadolinium enhanced)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Adapted Mirror Therapy on Individuals With Hemiparesis of the Upper Limb Following a Stroke
Status: COMPLETED
Conditions: Hemiparesis
Interventions: BEHAVIORAL: routine rehabilitation therapy|BEHAVIORAL: Modified mirror therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Spironolactone on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess
Status: RECRUITING
Conditions: Obesity|Hyperandrogenemia|Polycystic Ovary Syndrome
Interventions: DRUG: Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Training Intervention in a Controlled Population of Frail Elderly
Status: COMPLETED
Conditions: Physical Activity
Interventions: OTHER: Multicomponent training intervention|OTHER: Nutritional intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Intravitreal 5-Fluorouracil and Heparin to Prevent PVR in High-risk Patients With Retinal Detachment.
Status: COMPLETED
Conditions: Rhegmatogenous Retinal Detachment|High-risk for Proliferative Vitreoretinopathy (PVR)
Interventions: DRUG: 5-fluorouracil and low molecular weight heparin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION