pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety of Transarterial Therapies+Donafenib + Anti-PD-1 Antibody for uHCC: A Retrospective Real-world Study
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma Non-resectable
Interventions: PROCEDURE: transarterial therapies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Efficacy and Safety of ASP1941 in Asian Subjects With Type 2 Diabetes Mellitus
Status: TERMINATED
Conditions: Type II Diabetes Mellitus
Interventions: DRUG: ASP1941|DRUG: acarbose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Routine Physical Therapy With and Without Core Stability Exercises in Patients With Lumbar Radiculopathy
Status: COMPLETED
Conditions: Lumbar Radiculopathy
Interventions: OTHER: Core strengthening|OTHER: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Renin Inhibition on Insulin Sensitivity, Diastolic Function and Aortic Compliance
Status: TERMINATED
Conditions: Insulin Sensitivity|Aortic Compliance|Diastolic Function
Interventions: DRUG: Aliskiren|DRUG: Valsartan and Aliskiren|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hippocampal-Avoiding Whole Brain Irradiation With Simultaneous Integrated Boost for Treatment of Brain Metastases
Status: COMPLETED
Conditions: Brain Neoplasms, Adult, Malignant
Interventions: RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Incidence and Change in Existing Pressure Ulcers: TC500 Bed Compared With Standard Beds
Status: COMPLETED
Conditions: Pressure Ulcers
Interventions: DEVICE: P500 Mattress
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety, PK, and Pharmacodynamics of LIB003
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: BIOLOGICAL: LIB003
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Trial of Stereotactic Body Radiation Therapy
Status: COMPLETED
Conditions: Inoperable Stage I/II Non-small Cell Lung Cancer
Interventions: RADIATION: Stereotactic Body Radiation Therapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Etoricoxib (MK-0663) in Patients With Spondyloarthropathy (SpA)/Ankylosing Spondylitis (AS) in Sweden (EP07013.013.11.082)
Status: COMPLETED
Conditions: Spondylarthropathies; Spondylitis, Ankylosing
Interventions: DRUG: etoricoxib|DRUG: Other COX-2 inhibitor|DRUG: nsNSAIDs
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Study of TOLAMBA™ in Ragweed-Allergic Adults
Status: TERMINATED
Conditions: Rhinitis, Allergic, Seasonal
Interventions: BIOLOGICAL: Amb a 1 immunostimulatory oligodeoxyribonucleotide conjugate|BIOLOGICAL: Histamine base
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluate Measurement Instruments Relevance in Assessing Effectiveness of ACARIZAX® in House Dust Mite Allergic Rhinitis
Status: ENROLLING_BY_INVITATION
Conditions: Allergic Rhinitis Due to House Dust Mite|Allergic Asthma
Interventions: DRUG: Standardised allergen extract from house dust mites
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of VVN001 Ophthalmic Solution in Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: VVN001 Ophthalmic Solution 1%|DRUG: VVN001 Ophthalmic Solution 5%|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thoracotomy Closure Technique and Postoperative Pain Study: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Hernia|Lung Cancer
Interventions: PROCEDURE: Pericostal suture technique|PROCEDURE: Intracostal suture technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SMART Stepped Care Management for Low Back Pain in the Military Health System
Status: ACTIVE_NOT_RECRUITING
Conditions: Low Back Pain|Chronic Pain|Military Personnel|Veterans
Interventions: BEHAVIORAL: Physical Therapy|BEHAVIORAL: Move 2 Health (M2H)|BEHAVIORAL: MORE Mindfulness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Supporting Patient Care With Electronic Resources in the United States
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: BEHAVIORAL: US-ANSWER-2 decision aid|BEHAVIORAL: Control group (Online medication guide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultrasound Guided Transversus Abdominis Plane(TAP) Block in Intensive Care Unit
Status: UNKNOWN
Conditions: Colon Neoplasm|Rectum Neoplasm|Perforated Colon|Perforated Bowel
Interventions: DRUG: 0.25% Bupivacaine, 0.5mL/kg|DRUG: Normal Saline|DEVICE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Dense Chemotherapy Plus Bevacizumab in High Risk Lymph Node Positive Breast Cancer: A Pilot Study
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: bevacizumab combined with dose dense chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ABT-869 in Subjects With Advanced Renal Cell Carcinoma Who Have Previously Received Treatment With Sunitinib
Status: COMPLETED
Conditions: Advanced Renal Cell Carcinoma
Interventions: DRUG: ABT-869
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adductor Canal Block (ACB) vs Femoral Nerve Block (FNB) in Revision Total Knee Arthroplasty
Status: TERMINATED
Conditions: Revision Total Knee Arthroplasty
Interventions: PROCEDURE: Nerve Block for pain control post-revision total knee arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ketamine + Cognitive Training for Suicidality in the Medical Setting
Status: ENROLLING_BY_INVITATION
Conditions: Suicide, Attempted
Interventions: DRUG: Intravenous ketamine|BEHAVIORAL: Cognitive training|BEHAVIORAL: Sham Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating Inter-individual Variability in Glycemic and Insulin Responses
Status: COMPLETED
Conditions: Hyperglycemia|Insulin Sensitivity
Interventions: OTHER: Jasmine rice|OTHER: Parboiled basmati rice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Efficacy and Safety of JTE-451 in Subjects With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis|Psoriasis|Skin Diseases
Interventions: DRUG: JTE-451 Tablets|DRUG: Placebo Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PK and PD of Antibiotics for Treatment of Mycobacterium Abscessus Pulmonary Disease
Status: NOT_YET_RECRUITING
Conditions: Nontuberculous Mycobacterial Pulmonary Infection
Interventions: OTHER: Measuring PK and PD indices in patients who receive conventional treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Optimization of Hemodynamic Conditions During Caesarean Section Under Spinal Anaesthesia
Status: COMPLETED
Conditions: Caesarean Section
Interventions: DRUG: Phenylephrine|DEVICE: Lower limb compression|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Morphometry in OA Patients Treated With Duloxetine
Status: COMPLETED
Conditions: Pain|Osteoarthritis
Interventions: DRUG: Duloxetine|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pelvic Floor Muscle Training and Biofeedback or Standard Therapy in Men Who Have Undergone Radical Prostatectomy or Transurethral Resection of the Prostate
Status: COMPLETED
Conditions: Nonmalignant Neoplasm|Prostate Cancer|Psychosocial Effects of Cancer and Its Treatment|Sexual Dysfunction|Urinary Incontinence
Interventions: BEHAVIORAL: exercise intervention|OTHER: questionnaire administration|PROCEDURE: biofeedback|PROCEDURE: management of therapy complications|PROCEDURE: psychosocial assessment and care|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy Study of Paliperidone to Evaluate Subjective Change in Well-being and Drug Attitude in Schizophrenic Participants
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Paliperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Evaluation of Late Rectal Injury Following CyberKnife Radiosurgery for Prostate Cancer
Status: TERMINATED
Conditions: Stage II Prostate Carcinoma
Interventions: RADIATION: CyberKnife radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-Migration System for Anti-reflux Oeso-gastric Stent (ANTIMIG)
Status: RECRUITING
Conditions: Stent Migration|GastroEsophageal Cancer
Interventions: DEVICE: Gastroesophageal stent placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Single-blind, Dose-ranging Study of Novel Swine Influenza Virus Vaccine in Japanese Adult Subjects
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Adjuvanted cell-derived, inactivated novel swine origin A/H1N1 monovalent subunit influenza virus vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Paravertebral Block With General Anesthesia in Patients Undergoing Breast Cancer Surgery
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: Paravertebral Block|PROCEDURE: General Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vela China Study: in Cutting And Hemostasis For Gastrointestinal Epithelial Neoplasia In Chinese Population
Status: TERMINATED
Conditions: Indication for Modification of Patient Physical Status
Interventions: DEVICE: Vela XL thulium laser, laser fiber and accessories.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Supplement on Symptom Awareness and Heart Rhythm in Patients With Cardiac Arrhythmia
Status: COMPLETED
Conditions: Cardiac Arrhythmia
Interventions: DIETARY_SUPPLEMENT: MNC-01|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 68Ga PET/CT Versus 99mTc SPECT/CT for Lung Perfusion and Ventilation Scintigraphy; a Technical and Practical Feasibility Study
Status: RECRUITING
Conditions: Pulmonary Embolism|Ventilation Perfusion Mismatch
Interventions: DIAGNOSTIC_TEST: Ga-68 V/Q PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Campath-1H and EPOCH to Treat Non-Hodgkin's T- and NK-Cell Lymphomas
Status: COMPLETED
Conditions: Lymphoma, T-Cell|Lymphoma, Extranodal NK-T-Cell
Interventions: BIOLOGICAL: Alemtuzumab (Campath)|DRUG: EPOCH
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Ultrasound Help Junior Anesthesia Residents With Placement of Labor Analgesia in Pregnant Patients
Status: TERMINATED
Conditions: Pregnancy
Interventions: DEVICE: Ultrasound|PROCEDURE: No ultrasound|PROCEDURE: Epidural infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Momelotinib Versus Ruxolitinib in Subjects With Myelofibrosis
Status: COMPLETED
Conditions: Primary Myelofibrosis|Post-Polycythemia Vera Myelofibrosis|Post-Essential Thrombocythemia Myelofibrosis
Interventions: DRUG: Momelotinib|DRUG: Ruxolitinib|DRUG: Placebo to match momelotinib|DRUG: Placebo to match ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Organ Preservation With Durvalumab-based Immunotherapy in Combination With Chemoradiation as Definitive Therapy for Early Stage Esophageal Adenocarcinoma With Indication for Radical Surgery
Status: RECRUITING
Conditions: Esophagus Adenocarcinoma
Interventions: DRUG: Durvalumab|DRUG: FLOT|DRUG: mFOLFOX-6|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transapical Implantation of the Medtronic Engager Transcatheter Aortic Valve Implantation System - The Engager European Pivotal Trial
Status: COMPLETED
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: Medtronic Engager Transcatheter Aortic Valve Implantation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Evaluate the Safety and Efficacy of CKD-498 in Female Patients With Androgenetic Alopecia
Status: COMPLETED
Conditions: Androgenetic Alopecia
Interventions: DRUG: CKD-498 dose#1|DRUG: CKD-498 dose#2|DRUG: CKD-498 dose#3|DRUG: Placebo of CKD-498 dose#1|DRUG: Placebo of CKD-498 dose#2|DRUG: Placebo of CKD-498 dose#3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Versartis Trial in Pre-pubertal Japanese Children With Growth Hormone Deficiency (GHD) to Assess Long-Acting Growth Hormone (Somavaratan, VRS-317)
Status: TERMINATED
Conditions: Pediatric Growth Hormone Deficiency|Growth Disorders
Interventions: DRUG: Somavaratan (VRS-317)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Proof-of-principle Clinical Study Investigating the Efficacy of an Experimental Dentifrice Containing Sodium Bicarbonate and Sodium Hyaluronate on Gingivitis
Status: COMPLETED
Conditions: Gingivitis
Interventions: OTHER: Experimental Dentrifrice|OTHER: Positive control dentifrice|OTHER: Negative control dentifrice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Within Subject Crossover Study of Cognitive Effects of Neflamapimod in Early-Stage Huntington Disease
Status: TERMINATED
Conditions: Huntington Disease
Interventions: DRUG: neflamapimod|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trail of Uterosacral Ligament Suspension in the Treatment of Pelvic Organ Prolapse
Status: NOT_YET_RECRUITING
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: Laparoscopic uterosacral ligament suspension with hysterectomy|PROCEDURE: Laparoscopic uterosacral ligament suspension with cervical amputation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Olaparib in Treating Patients With Stage IV Pancreatic Cancer
Status: COMPLETED
Conditions: Metastatic Pancreatic Adenocarcinoma|Pancreatic Ductal Adenocarcinoma|Stage IV Pancreatic Cancer AJCC v6 and v7
Interventions: DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia, Osteosarcoma, or Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Leukemia|Lymphoma|Sarcoma
Interventions: DRUG: leucovorin calcium|DRUG: trimetrexate glucuronate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Nebulized Magnesium Sulfate as an Adjunct to Standard Therapy in Asthma Exacerbation
Status: UNKNOWN
Conditions: Asthma
Interventions: DRUG: Nebulized Magnesium Sulfate|DRUG: Nebulized isotonic saline|DRUG: Nebulized Salbutamol|DRUG: Ipratropium bromide|DRUG: Methylprednisolone or Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transplantation Using Hepatitis C Positive Donors, A Safety Trial
Status: RECRUITING
Conditions: Lung Transplant Infection|Heart Transplant Infection|Kidney Transplant Infection|Kidney Pancreas Infection|Hepatitis C
Interventions: DRUG: Glecaprevir 300 MG / Pibrentasvir 120 MG Oral Tablet|DRUG: Ezetimibe 10Mg Oral Tablet|DEVICE: Ex Vivo Lung Perfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Crenolanib Combined With Standard Salvage Chemotherapy in Subjects With R/R AML
Status: COMPLETED
Conditions: Relapsed/Refractory Acute Myeloid Leukemia (AML)
Interventions: DRUG: Crenolanib|DRUG: Mitoxantrone|DRUG: Cytarabine|DRUG: Etoposide|DRUG: Fludarabine|DRUG: G-CSF|DRUG: Idarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Liraglutide on Sensory Perception, Sensory Specific Satiety, Liking and Wanting in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Overweight
Interventions: DRUG: Liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: CT-derived Virtual Stenting Optimize Coronary Revascularization (CT-COMPASS)
Status: RECRUITING
Conditions: Percutaneous Coronary Intervention|Coronary Physiology|Computed Tomography
Interventions: OTHER: Virtual stent-guided incremental optimization strategy (VIOS)|OTHER: Standard angiographic strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Mavorixafor in Combination With Ibrutinib in Participants With Waldenstrom's Macroglobulinemia (WM) Whose Tumors Express Mutations in MYD88 and CXCR4
Status: COMPLETED
Conditions: Waldenstrom's Macroglobulinemia
Interventions: DRUG: Mavorixafor|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maximizing the Impact of Neuroplasticity Using Transcranial Electrical Stimulation Study 2
Status: ACTIVE_NOT_RECRUITING
Conditions: Transcranial Direct Current Stimulation|Schizophrenia|Schizoaffective Disorder
Interventions: DEVICE: Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Health Intervention Program for Children With Congenital Heart Defects
Status: COMPLETED
Conditions: Congenital Heart Defect|Dental Caries in Children|Dental Erosion|Dental Plaque|Hypomineralization, Tooth
Interventions: OTHER: Oral health intervention program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: C-MAC Video Laryngoscope and VS-CMAC Fiberoptic Stylet for Awake Endoscopic Intubation in Predicted Difficult Airways
Status: UNKNOWN
Conditions: Difficult Airway Intubation
Interventions: DEVICE: VS-CMAC Rigid Fiberoptic Stylet|DEVICE: C-MAC Video laryngoscope awake intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Gonadotrophin Releasing Hormone Agonist Addition for Luteal Support in In-vitro Fertilization and Embryo Transfer Cycles
Status: UNKNOWN
Conditions: GnRHa;LPS
Interventions: DRUG: Gonadotrophin releasing hormone agonist(GnRHa)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Psychological-behavioral Intervention to Increase Activity in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Positive Psychology + Motivational Interviewing|BEHAVIORAL: Diabetes Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Enzymes on Dental Biofilm Accumulation
Status: COMPLETED
Conditions: Dental Plaque
Interventions: DIETARY_SUPPLEMENT: Enzyme-containing lozenge|DIETARY_SUPPLEMENT: Placebo lozenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Lithium-Based Medication to Improve Neurological Outcomes After Surgical Carotid Reconstruction
Status: RECRUITING
Conditions: Carotid Artery Diseases|Carotid Artery Stenosis
Interventions: DRUG: Lithium Carbonate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multinational Clinical Study Comparing Isatuximab, Pomalidomide, and Dexamethasone to Pomalidomide and Dexamethasone in Refractory or Relapsed and Refractory Multiple Myeloma Patients
Status: COMPLETED
Conditions: Plasma Cell Myeloma
Interventions: DRUG: Isatuximab|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Biomechanical Evaluation of the Ossur Power Knee in Persons With Transfemoral Amputation
Status: RECRUITING
Conditions: Transfemoral Amputation|Limb Loss|Limb Absence
Interventions: OTHER: Powered prosthetic knee joint|OTHER: Conventional prosthetic knee joint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictor for an Additional Benefit of Inhaled Corticosteroid in Patients Treated With Tiotropium for COPD
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Swedish BioFINDER 2 Study
Status: RECRUITING
Conditions: Dementia|Alzheimer Disease|Parkinson Disease|Lewy Body Disease|Parkinson-Dementia Syndrome|Frontotemporal Degeneration|Semantic Dementia|Progressive Nonfluent Aphasia|Progressive Supranuclear Palsy|Corticobasal Degeneration|Multiple System Atrophy|Mild Cognitive Impairment
Interventions: DIAGNOSTIC_TEST: Flutemetamol F18 Injection|DIAGNOSTIC_TEST: [18F]-RO6958948|DIAGNOSTIC_TEST: Elecsys (Roche) Abeta42, Ttau and Ptau|DIAGNOSTIC_TEST: Lumipulse (Fujirebio) Abeta42, Ttau and Ptau
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Study to Evaluate Safety and Dosing of CA9hu-1 in Patients With Advanced Solid Tumours
Status: NOT_YET_RECRUITING
Conditions: Clear Cell Renal Cell Carcinoma Metastatic|TNBC - Triple-Negative Breast Cancer|Head and Neck Cancer|Non-small-cell Lung Carcinoma|Mesothelioma, Malignant
Interventions: DRUG: CA9hu-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modeling Treated Recovery From Aphasia
Status: COMPLETED
Conditions: Aphasia|Stroke|Stroke, Ischemic|Aphasia, Broca|Aphasia, Global|Aphasia, Mixed|Aphasia, Jargon|Aphasia, Expressive|Aphasia, Conduction|Aphasia, Fluent|Aphasia, Anomic
Interventions: BEHAVIORAL: Semantically focused treatment|BEHAVIORAL: Phonologically focused treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety of Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Upadacitinib|DRUG: Placebo for upadacitinib|DRUG: Topical Corticosteroids (TCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-Arm Feasibility Study Evaluating OTX-TP Compared to Timolol in Treatment of Subjects With Open Angle Glaucoma
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: OTX-TPa ~4µg/day over 2 mos. with natural tears drops|DRUG: OTX-TPb ~3µg/day over 3 months with natural tears drops|DRUG: Timolol Maleate (0.5%) dosed twice daily with punctum plug without drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Implementation of a Healthy Lifestyles Program
Status: COMPLETED
Conditions: Health Behavior|Quality of Life|Chronic Disease|Health Promotion|Stress|Mental Health Wellness 1
Interventions: BEHAVIORAL: Health and wellness learning sessions|BEHAVIORAL: Brainstorming group sessions|BEHAVIORAL: Individual sessions with a multidisciplinary health team|BEHAVIORAL: Health goal development|BEHAVIORAL: Physical activity and nutrition journals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Treatment of Enuresis Nocturna by Circular Muscle Exercise (Paula Method)
Status: UNKNOWN
Conditions: Monosymptomatic Enuresis Nocturna
Interventions: DRUG: Desmopresin|BEHAVIORAL: Paula Method of Circular Muscle Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Confirmatory Investigation to Evaluate the Performance and Safety of ReSpace TiCell Cage Implants in TLIF
Status: RECRUITING
Conditions: Degenerative Instability|Spondylolisthesis|Post-discectomy Syndrome|Post-traumatic Instability
Interventions: DEVICE: ReSpace TiCell Cage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Mitoxantrone Hydrochloride Liposome Injection in Subjects With Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Relapsed or Refractory Acute Myeloid Leukemia (AML)
Interventions: DRUG: Mitoxantrone Hydrochloride Liposome
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of n-3 PUFA From Fish in Enteral Nutrition of Major Burn Patients
Status: UNKNOWN
Conditions: Burn Injury
Interventions: DIETARY_SUPPLEMENT: ω-3 PUFA|DIETARY_SUPPLEMENT: Low fat enteral diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase II Study Of Abraxane and Nexavar in the First-Line Treatment of Locally Advanced or Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Paclitaxel Albumin Nanoparticle for Injectable Suspension (Abraxane)|DRUG: Sorafenib (Nexavar)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study for Heparin-free Hemodialysis With the Dialyzer With Endexo™
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Patient Requiring Heparin Free Dialysis Treatments
Interventions: DEVICE: Dialyzer with Endexo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of iCBT and Exercise for Chronic Knee Patients
Status: NOT_YET_RECRUITING
Conditions: Chronic Knee Pain
Interventions: OTHER: Standardized Exercise Program|OTHER: Internet based Cognitive Behavioral Therapy|OTHER: Educational Materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Dipeptidyl Peptidase-4 Inhibitor Sitagliptininsulin on the Progression of Coronary Atherosclerosis in Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Atherosclerosis Type 2 Diabetes Mellitus Dipeptidyl Peptidase-4 Inhibitor GLP-1
Interventions: DRUG: Sitagliptin|DRUG: Acarbose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Betaserc on Vestibular Compensation in Patients Suffering From Disabling Meniere's Disease and Having Undergone Vestibular Neurotomy
Status: COMPLETED
Conditions: Meniere's Disease
Interventions: DRUG: Betahistine 24 mg bid (Betaserc)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: CMV-TCR-T Cells for Refractory CMV Infection After HSCT
Status: UNKNOWN
Conditions: Allogeneic Hematopoietic Stem Cell Transplantation|CMV Infection
Interventions: BIOLOGICAL: CMV-TCR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Axitinib as Maintenance Treatment in Patients With Metastatic CRC
Status: TERMINATED
Conditions: Colorectal Carcinoma
Interventions: DRUG: axitinib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TMC125-TiDP35-C239 - Continued Access to Etravirine (ETR) in Treatment Experienced HIV-1 Infected Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections|HIV-1
Interventions: DRUG: Etravirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigational Drug Study in Patients With Elevated Cholesterol and Coronary Heart Disease (0653-804)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia|Coronary Disease
Interventions: DRUG: MK0653, ezetimibe|DRUG: Comparator: ezetimibe, placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Drugs for Treatment of Visceral Leishmaniasis in Brazil
Status: TERMINATED
Conditions: Visceral Leishmaniasis
Interventions: DRUG: Antimoniate of N-methylglucamine|DRUG: amphotericin B deoxycholate|DRUG: Liposomal amphotericin B|DRUG: Liposomal amphotericin B|DRUG: Antimoniate of N-methylglucamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Efficacy of AZD2811 Nanoparticles as Monotherapy or in Combination in Acute Myeloid Leukemia Participants.
Status: TERMINATED
Conditions: Acute Myeloid Leukaemia
Interventions: DRUG: AZD2811|DRUG: Azacitidine|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Clinical Study of CD19 UCAR-T Cells in Patients With B-cell Acute Lymphoblastic Leukemia (B-ALL)
Status: UNKNOWN
Conditions: B-cell Acute Lymphoblastic Leukemia (B-ALL)|Safety and Efficacy of CD19 UCAR-T Cells
Interventions: BIOLOGICAL: CD19 UCARTcells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of DE-104 Ophthalmic Solution to Treat Open-angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: DE-104 ophthalmic solution, low concentration|DRUG: DE-104 ophthalmic solution, medium concentration|DRUG: DE-104 ophthalmic solution, high concentration|DRUG: Placebo|DRUG: 0.005% latanoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Gadopiclenol for Body Magnetic Resonance Imaging (MRI)
Status: COMPLETED
Conditions: Lesion in Body Region
Interventions: DRUG: gadopiclenol|DRUG: Gadobutrol 1 MMOLE/ML Intravenous Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Modified Immune Cells (CD19-CD22 CAR T Cells) in Treating Patients With Recurrent or Refractory CD19 Positive, CD22 Positive Leukemia or Lymphoma
Status: WITHDRAWN
Conditions: CD19 Positive|CD22 Positive|Minimal Residual Disease|Progressive Disease|Recurrent B Acute Lymphoblastic Leukemia|Recurrent Chronic Lymphocytic Leukemia|Recurrent Non-Hodgkin Lymphoma|Refractory B Acute Lymphoblastic Leukemia|Refractory Chronic Lymphocytic Leukemia|Refractory Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: Autologous CD19/CD22 Chimeric Antigen Receptor T-cells|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Interactions From Simultaneous Administration Of Metformin And GSK189075 To Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Diabetes Mellitus, Type 2
Interventions: DRUG: GSK189075 oral tablets|DRUG: metformin tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET/MR for Characterization of Renal Masses (RMs)
Status: RECRUITING
Conditions: Renal Tumor|Renal Cell Carcinoma|Renal Tumor, Benign
Interventions: DIAGNOSTIC_TEST: 2-Deoxy-2-[18F]fluoroglucose Positron Emission Tomography/Magnetic Resonance Imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cardiorespiratory and Acid-basic Imbalance Caused by Use of Mask
Status: COMPLETED
Conditions: Acid-Base Imbalance|Respiration Disorders
Interventions: DEVICE: Mask Zero Seam Virus Bac-Off Lupo® 98% Polyamide and 2% Elastane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: First-in-Human Study of SRT-015 in Healthy Subjects.
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis
Interventions: DRUG: SRT-015|OTHER: Matching Placebo for SRT-015
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Benzodiazepines for the Reduction of Distress and Pain During and After Emergency Department Care
Status: TERMINATED
Conditions: Acute Pain
Interventions: DRUG: Placebos|DRUG: Lorazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Visual Perceptual Motor Training on Kindergarteners
Status: RECRUITING
Conditions: Agraphia
Interventions: BEHAVIORAL: Chinese character-based visuomotor training program|BEHAVIORAL: traditional visuomotor training program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Improving Glycaemic Control in Malaysian Patients With Type 2 Diabetes Mellitus With Insulin Pump Therapy
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DEVICE: Insulin Pump|DRUG: Multiple daily injections of insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Intermittent Hypoxia (IH) on Metabolism and Dysglycemia, in Overweight/Obese Persons SCI
Status: COMPLETED
Conditions: Spinal Cord Injuries|Obesity|Insulin Resistance
Interventions: DEVICE: Intermittent Hypoxia (IH)|DEVICE: SHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prospective Study of the BioVentrix PliCath HF™ System for the Treatment of Ischemic Cardiomyopathy
Status: COMPLETED
Conditions: Heart Failure
Interventions: DEVICE: PliCath HF System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Xacrel® (Ocrelizumab) in Participants With Relapsing Remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Relapsing-Remitting
Interventions: BIOLOGICAL: Ocrelizumab (CinnaGen, Iran)|BIOLOGICAL: Ocrelizumab (Roche, Switzerland)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study, Evaluating Pharmacokinetics, Pharmacodynamics, Immunogenicity and Safety Profiles of Rituximab Compared to MabThera® in Patients With Rheumatoid Arthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Rituximab|DRUG: MabThera®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Pharmacokinetic Study of Gepotidacin in Subjects With Varying Degrees of Renal Impairment and in Subjects With Normal Renal Function
Status: COMPLETED
Conditions: Infections, Bacterial
Interventions: DRUG: Gepotidacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Two ONS in Patients at Nutritional Risk With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes|Malnutrition
Interventions: DIETARY_SUPPLEMENT: Diabetic|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis
Status: COMPLETED
Conditions: Bacterial Meningitis
Interventions: DRUG: Infusion with paracetamol|DRUG: Bolus without paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Distalization Via Skeletally-anchored Distaljet Appliance With Two Approaches of Micro-osteoperforations
Status: UNKNOWN
Conditions: Class II Division 1 Malocclusion
Interventions: DEVICE: skeletally anchored distal jet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Perioperative Remodulin® in Orthotopic Liver Transplant Recipients
Status: WITHDRAWN
Conditions: Liver Transplant
Interventions: DRUG: treprostinil sodium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors
Status: RECRUITING
Conditions: Central Nervous System Tumor|Diffuse Intrinsic Pontine Glioma|Diffuse Midline Glioma|Ependymoma|Medulloblastoma, Childhood|Germ Cell Tumor|Atypical Teratoid/Rhabdoid Tumor|Primitive Neuroectodermal Tumor|Choroid Plexus Carcinoma|Pineoblastoma, Childhood|Glioma
Interventions: BIOLOGICAL: SCRI-CARB7H3(s); B7H3-specific chimeric antigen receptor (CAR) T cel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Mapping of the Anterior Temporal Lobe Using Functional MRI Innovative Techniques in in Drug-resistant Epileptic Patients
Status: RECRUITING
Conditions: Epilepsy, Temporal Lobe|Cognitive Decline
Interventions: RADIATION: functional MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Amiodarone for the Prevention of Atrial Fibrillation After Minimally Invasive Esophagectomy in Patients With Esophageal Cancer
Status: RECRUITING
Conditions: Atrial Fibrillation|Esophageal Carcinoma
Interventions: DRUG: Amiodarone Hydrochloride|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Support for People Undergoing Chemotherapy
Status: COMPLETED
Conditions: Quality of Life|Cancer
Interventions: BEHAVIORAL: Stress Management training|BEHAVIORAL: Exercise Training|BEHAVIORAL: Usual care|BEHAVIORAL: Combined stress management and exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioequivalence Study of a Test Capsule Formulation of Fingolimod With the Reference Capsule Formulation of Fingolimod
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Fingolimod Reference Formulation|DRUG: Fingolimod Test Formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: National Observational Study On The Use Of Inflectra™ An Infliximab Biosimilar In Real Life
Status: COMPLETED
Conditions: Crohn Disease|Ulcerative Colitis|Rheumatoid Arthritis|Ankylosing Spondylitis|Psoriatic Arthritis
Interventions: OTHER: QOL questionaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Observational Study for the Evaluation of Long-term Safety of Radium-223 Used for the Treatment of Metastatic Castration Resistant Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: Radium-223 dichloride (Xofigo, BAY88-8223)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Low-Phosphate Diet and Fibroblast Growth Factor-23 Level
Status: COMPLETED
Conditions: Chronic Kidney Disease Requiring Chronic Dialysis|Hyperphosphatemia|Dietary Intervention|Elevated Fibroblast Growth Factor-23
Interventions: OTHER: Low-phosphate diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2a Study on Allogeneic Osteoblastic Cells Implantation in Lumbar Spinal Fusion
Status: COMPLETED
Conditions: Degenerative Disc Disease
Interventions: DRUG: ALLOB® cells with ceramic scaffold
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gait Analysis in Patients Underwent Total Knee Arthroplasty With a Medial Pivot Design.
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DIAGNOSTIC_TEST: Gait Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Ciprofol on Breathing Patterns, Respiratory Drive, and Inspiratory Effort in Mechanically Ventilated Patients
Status: RECRUITING
Conditions: Mechanical Ventilation|Sedation and Analgesia
Interventions: DRUG: ciprofol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT