pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Efficacy & Safety for 3 Infusion Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia
Status: COMPLETED
Conditions: Hyponatremia
Interventions: DRUG: Conivaptan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced Metastatic Urothelial Cancer
Status: RECRUITING
Conditions: Urothelial Cancer
Interventions: DRUG: Atezolizumab|DRUG: Tobemstomig|DRUG: Tiragolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gut Microbiome and p-Inulin in CKD - TarGut CKD Study
Status: UNKNOWN
Conditions: Chronic Kidney Diseases
Interventions: DIETARY_SUPPLEMENT: Oligofructose-enriched inulin (p-inulin)|OTHER: No treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of the Effectiveness of Erector Spina Plane Block and Transforaminal Anterior Epidural Injections
Status: ACTIVE_NOT_RECRUITING
Conditions: Lumbar Disc Herniation|Radiculopathy Lumbar
Interventions: PROCEDURE: Transforaminal Epidural Steroid Injection|PROCEDURE: Erector Spina Plane Block
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Platelet Rich Fibrin (PRF) in Socket Preservation Technique
Status: ACTIVE_NOT_RECRUITING
Conditions: Alveolar Bone Loss|Tooth Extraction
Interventions: PROCEDURE: Dental extraction|DEVICE: Platelet Rich Fibrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of the Selective Inhibitor of Nuclear Export (SINE) KPT-330 in Patients With Advanced Hematological Cancer
Status: COMPLETED
Conditions: Hematological Malignancies
Interventions: DRUG: KPT-330
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Esketamine, Sufentanil, or Lidocaine on Tussis Reflection During Upper Gastroscopy
Status: RECRUITING
Conditions: Anesthesia
Interventions: DRUG: propofol|DRUG: propofol and sufentanil|DRUG: propofol and esketamine|DRUG: propofol and lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Intraperitoneal Bupivacaine Alone or With Dexmedetomidine
Status: COMPLETED
Conditions: LAPAROSCOPIC CHOLECYSTECTOMY
Interventions: DRUG: Bupivacaine injection|DRUG: Dexmedetomidine injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Zoledronic Acid Versus Observation on Bone Mineral Density and Incidence of Micrometastasis in Women Undergoing Pelvic Radiation for Cervical Cancer
Status: TERMINATED
Conditions: Uterine Cervical Neoplasms
Interventions: DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Methyl B12 on Behavioral and Metabolic Measures in Children With Autism
Status: COMPLETED
Conditions: Autistic Disorder
Interventions: DRUG: Methyl B12|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Upper Limb Task-Oriented Rehabilitation With Robotic Exoskeleton for Hemiparetic Stroke Patients
Status: COMPLETED
Conditions: Cerebrovascular Accident (CVA)|Chronic Disease|Stroke Rehabilitation
Interventions: DEVICE: Upper Arm Rehabilitation Light Exoskeleton (RH-LEXOS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Pinitol on Hidrocarbonated Metabolism Parameters in Diabetic, Impaired and Normal Fasting Glucose Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes|Impaired Glucose Tolerance|Healthy
Interventions: DIETARY_SUPPLEMENT: Pinitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Sleep Related Breathing Disorders in Patients With Pulmonary Hypertension
Status: COMPLETED
Conditions: Pulmonary Hypertension|Breathing-Related Sleep Disorder
Interventions: DRUG: acetazolamide|OTHER: Supplemental oxygen|PROCEDURE: Non-invasive ventilation|OTHER: Room air|DRUG: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Piezo-surgical Implant With Laser
Status: UNKNOWN
Conditions: Effect of Piezo-surgical Implant With Laser on Pain and Swelling in Patients With Missing Teeth
Interventions: DEVICE: Piezo-surgery with low level laser therapy|DEVICE: Piezo-surgery only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Absorption of Bioactive Berberine in Human
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Berberine|DIETARY_SUPPLEMENT: TPGS emulsified berberine|DIETARY_SUPPLEMENT: Quillaja extract emulsified berberine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Brief Eclectic Psychotherapy for PTSD - a Randomized Controlled Trial
Status: COMPLETED
Conditions: Chronic Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Brief Eclectic Psychotherapy for PTSD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EPLERAF-Study: Eplerenone in the Prevention of Atrial Fibrillation Recurrences After Cardioversion
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: DRUG: Eplerenone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Allogeneic Adipose-Derived Mesenchymal Stem Cells to Treat Post COVID-19 "Long Haul" Pulmonary Compromise
Status: WITHDRAWN
Conditions: Covid19
Interventions: BIOLOGICAL: COVI-MSC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Hemodialysis on Endothel-Depending Dilatation of Peripheral Arteries
Status: COMPLETED
Conditions: Hemodialysis
Interventions: PROCEDURE: blood sample|PROCEDURE: Flow-mediated dilation (FMD) before and after a single HD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Powdered Intrawound Vancomycin in Open Fractures Trial
Status: NOT_YET_RECRUITING
Conditions: Open Fracture|Trauma|Infection, Surgical Site|Fractures, Open|Wound Infection|Fractures, Bone|Post-Operative Wound Infection
Interventions: DRUG: Vancomycin 1000 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Efficacy of Once Daily Amlodipine/Valsartan 5/80 as Compared to Amlodipine/Valsartan 5/40 or to Amlodipine 5 mg Monotherapy in Patients 65 Years of Age and Older With Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Amlodipine 5 mg|DRUG: Valsartan 80 mg|DRUG: Valsartan 40 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biocollection of Patients With ANCA Associated Vasculitis
Status: RECRUITING
Conditions: ANCA-associated Vasculitis
Interventions: OTHER: Blood samples (80 mL)|OTHER: Fecal samples|OTHER: Urinary sample (20-40 mL)|OTHER: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: BENTO - Bronchoscopic Lung Volume Reduction in Severe Emphysema Using Thermoablation
Status: NOT_YET_RECRUITING
Conditions: Emphysema or Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: InterVapor®-System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Glucometabolic Evaluation of Patients With Idiopathic Ketotic Hypoglycemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Idiopathic Ketotic Hypoglycemia
Interventions: BIOLOGICAL: Oral glucose tolerance test|BIOLOGICAL: Mixed meal test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Psychopharmacology for Cocaine Dependence - Buspirone
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: Buspirone|DRUG: Placebo for Buspirone|DRUG: Methylphenidate|DRUG: Placebo for Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Improving Patient and Family Centered Care in Advanced Critical Illness
Status: COMPLETED
Conditions: Anxiety|Depression
Interventions: BEHAVIORAL: The PARTNER Intervention|OTHER: ICU Usual Care Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combined Cytotoxic and Immune-Stimulatory Therapy for Glioma
Status: COMPLETED
Conditions: Malignant Glioma|Glioblastoma Multiforme
Interventions: BIOLOGICAL: Dose Escalation of Ad-hCMV-TK and Ad-hCMV-Flt3L
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myotonometer Analyses of Muscles in Multiple Sclerosis Patients With Dysphagia
Status: COMPLETED
Conditions: Multiple Sclerosis|Dysphagia|Swallowing Disorder|Deglutition Disorders|Muscle Tonus
Interventions: OTHER: DYMUS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Persona TKA With iASSIST Knee System and iASSIST Knee System
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Persona Knee System|PROCEDURE: Total Knee Arthroplasty|DEVICE: iAssist Knee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Analgesic Effect Of Intra-articular Bupivacaine Fentanyl for Postoperative Pain Relief in Knee Arthroscopic Surgery
Status: COMPLETED
Conditions: Knee Arthroscopic Surgery
Interventions: DRUG: Group DB/Dexamethasone-Bupivacaine|DRUG: Group FB /Fentanyl-Bupivacaine|DRUG: Group PB/Placebo-Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Green Tea With Aloe Vera Mouthwash and Chlorohexidine Mouthwash
Status: UNKNOWN
Conditions: Halitosis
Interventions: DRUG: Green Tea With Aloe Vera mouthwash|DRUG: Chlorhexidine mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sphenopalatine Ganglion Blockade in Migraine
Status: UNKNOWN
Conditions: Episodic Migraine
Interventions: DRUG: Lidocaine Hydrochloride 1% Solution for Injection_#2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: (Cost-)Effectiveness Interdisciplinary Community-based COPD Management Program (INTERCOM)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: INTERdisciplinary COMmunity-based COPD management (INTERCOM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Outcomes Assessment of the C-Leg With a New Knee Prosthesis
Status: COMPLETED
Conditions: Other and Unspecified Complications of Amputation Stump
Interventions: DEVICE: Otto Bock C-Leg|DEVICE: Otto Bock Genium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Taspoglutide Versus Placebo for the Treatment of Obese Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin Monotherapy
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: placebo|DRUG: taspoglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Type of Conduit-duct Anastomosis Technique on the Postoperative Course in Patients Undergoing Liver Transplantation
Status: NOT_YET_RECRUITING
Conditions: Liver Transplant; Complications|Bile Duct; Stricture, Postoperative|Bile Leak|Quality of Life
Interventions: PROCEDURE: Continous suture technique|PROCEDURE: Interrupted suture technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Comparison of Gabapentin and Ketamine in Acute and Chronic Pain After Inguinal Hernia Repair
Status: COMPLETED
Conditions: Chronic Pain Following Surgical Procedure for Cancer
Interventions: OTHER: Gabapentin versus Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Construction and Application of Therapeutic System of Intelligent Decision-Oriented Hemodynamic Organized Therapy for Shock Patients
Status: RECRUITING
Conditions: Septic Shock
Interventions: DRUG: norepinephrine+vasopressin|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: nSTRIDE APS in Females With Primary Patellofemoral Osteoarthritis
Status: COMPLETED
Conditions: Patellofemoral Osteoarthritis
Interventions: DEVICE: nSTRIDE Autologous Protein Solution (APS) Kit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of LY3462817 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: LY3462817 IV|BIOLOGICAL: LY3462817 SC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety Study of Intravitreal Triamcinolone to Treat Diffuse Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetes Mellitus|Macular Edema
Interventions: DRUG: Triamcinolone Acetonide|PROCEDURE: Grid laser|PROCEDURE: Sham Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Effectiveness of Angular Stable Locking System (ASLS) in Patients With Distal Tibial Fractures
Status: COMPLETED
Conditions: Tibial Fractures
Interventions: DEVICE: ETN with ASLS|DEVICE: ETN locked with conventional locking bolts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fludarabine, Bendamustine, and Rituximab (FBR) for Relapsed Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Bendamustine|DRUG: Fludarabine|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Clinical Effects of 2 Doses of EVP-6124 in Subjects With Alzheimer's Disease Who Complete Study EVP-6124-024 or EVP-6124-025
Status: TERMINATED
Conditions: Alzheimer's Disease|Dementia
Interventions: DRUG: EVP-6124
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Synthetic Vascular Grafts in Patients With Peripheral Artery Disease (PAD) Who Require Artery Bypass.
Status: COMPLETED
Conditions: Peripheral Arterial Occlusive Disease
Interventions: DEVICE: vascular grafts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalency Study of Montelukast Chewable 5 mg Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Montelukast|DRUG: Singulair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Tranexamic Acid Versus Topical Vitamin C With Microneedling in Periorbital Hyperpigmentation; Comparative Study
Status: COMPLETED
Conditions: Periorbital Hyperpigmentation
Interventions: DRUG: vitamin c 20%|DRUG: Tranexamic acid 5mg/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab Plus Interleukin-2 in Treating Patients With Hematologic Cancer
Status: COMPLETED
Conditions: B-cell Adult Acute Lymphoblastic Leukemia|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Noncontiguous Stage II Adult Burkitt Lymphoma|Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma|Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma|Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma|Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma|Noncontiguous Stage II Adult Lymphoblastic Lymphoma|Noncontiguous Stage II Grade 1 Follicular Lymphoma|Noncontiguous Stage II Grade 2 Follicular Lymphoma|Noncontiguous Stage II Grade 3 Follicular Lymphoma|Noncontiguous Stage II Mantle Cell Lymphoma|Noncontiguous Stage II Marginal Zone Lymphoma|Noncontiguous Stage II Small Lymphocytic Lymphoma|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Splenic Marginal Zone Lymphoma|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Small Lymphocytic Lymphoma
Interventions: BIOLOGICAL: rituximab|BIOLOGICAL: aldesleukin|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept Study of Rilzabrutinib in Adult Participants With Moderate-to-severe Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Rilzabrutinib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Equivalent Minimum Alveolar Concentration (eMAC) During Propofol/Remifentanil Anesthesia
Status: COMPLETED
Conditions: General Anaesthesia
Interventions: DRUG: Propofol|DRUG: Low Remifentanil|DRUG: Heigh Remifentanil|PROCEDURE: Intubation|PROCEDURE: tetanic electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Different Therapies in Treating Infants With Newly Diagnosed Acute Leukemia
Status: UNKNOWN
Conditions: Leukemia
Interventions: BIOLOGICAL: anti-thymocyte globulin|DRUG: asparaginase|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: etoposide|DRUG: leucovorin calcium|DRUG: melphalan|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: mitoxantrone hydrochloride|DRUG: pegaspargase|DRUG: prednisolone|DRUG: prednisone|DRUG: therapeutic hydrocortisone|DRUG: thioguanine|DRUG: vincristine sulfate|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: umbilical cord blood transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of the Efficacy of Peptide T in HIV-Positive Individuals With Cognitive Impairment.
Status: COMPLETED
Conditions: HIV Infections|Cognition Disorders
Interventions: DRUG: Peptide T|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Immunogenicity and Safety of Etanercept Produced Using a Modified Process in Patients With Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Perioperative Adebrelimab Combined With XELOX in Resectable Locally Advanced Gastric/Gastroesophageal Junction Cancer (GC/GEJC)
Status: RECRUITING
Conditions: Adebrelimab (SHR-1316)|XELOX|GC/GEJC
Interventions: DRUG: Adebrelimab|DRUG: XELOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UCD19 CarT in Treatment of Pediatric B-ALL and B-NHL
Status: RECRUITING
Conditions: B-cell Acute Lymphoblastic Leukemia|B-cell Non Hodgkin Lymphoma
Interventions: DRUG: CD19CAR-CD3Zeta-4-1BB-Expressing Autologous T-Lymphocyte Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Itacitinib Combined With INCB024360 and/or Itacitinib Combined With INCB050465 in Advanced Solid Tumors
Status: TERMINATED
Conditions: Solid Tumors
Interventions: DRUG: Itacitinib|DRUG: Epacadostat|DRUG: Itacitinib|DRUG: INCB050465
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Paclitaxel Plus Trastuzumab in Treating Women With Palpable Breast Cancer That Can Be Removed by Surgery
Status: COMPLETED
Conditions: HER2/Neu Positive|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer
Interventions: DRUG: Cyclophosphamide|DRUG: Epirubicin Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel|PROCEDURE: Therapeutic Conventional Surgery|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Revised Tafenoquine Dose to Improve Radical Cure for Vivax Malaria
Status: RECRUITING
Conditions: Vivax Malaria
Interventions: DRUG: Tafenoquine|DRUG: Primaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxytocin for Couples Conflict Resolution
Status: COMPLETED
Conditions: Substance Misuse|Interpersonal Conflict|Neuroendocrine Reactivity
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Snacks, Smiles and Taste Preferences
Status: ACTIVE_NOT_RECRUITING
Conditions: Development, Child
Interventions: BEHAVIORAL: Low Sweet|BEHAVIORAL: Regular Sweet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PET Imaging of Vaso-Occlusive Crisis (VOC) in SCD
Status: RECRUITING
Conditions: Sickle Cell Disease
Interventions: RADIATION: Positron Emission Tomography|DRUG: Cu-64]-LLP2A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Phase I Clinical Study of SHR-2005 Intravesical Instillation in the Treatment of High-risk Non-muscle Invasive Bladder Cancer (NMIBC)
Status: RECRUITING
Conditions: High-risk Non-muscle Invasive Bladder Cancer
Interventions: DRUG: SHR-2005
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myo-inositol Versus Clomiphene Citrate in PCOS
Status: TERMINATED
Conditions: Ovulation Induction|Polycystic Ovary Syndrome|Clomiphene|Inositol
Interventions: DRUG: Myo-inositol|DRUG: Clomiphene Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Doses of Globalagliatin Hydrochloride in Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Hyperglycaemia (Diabetic)|Type 2 Diabetes Mellitus
Interventions: DRUG: Globalagliatin Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Correlation Between Creatine Phosphokinase and Pelvic Floor Muscle Strength in Postnatal Women
Status: RECRUITING
Conditions: Pelvic Floor; Rupture, Old (Postpartum)
Interventions: OTHER: Assessment of creatine phosphokinase|OTHER: Assessment of pelvic floor muscle strength
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ComVi and D-type Stent in Malignant GOO
Status: COMPLETED
Conditions: Gastric Outlet Obstruction
Interventions: DEVICE: uncovered D-type stent insertion|DEVICE: double-layered ComVi stent insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Three Opioid Detoxification Treatment Regimens
Status: WITHDRAWN
Conditions: Opioid-Related Disorders|Opioid Withdrawal
Interventions: DRUG: Buprenorphine/naloxone|DRUG: Morphine|DRUG: Tramadol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotics for Infectious Diarrhea in Children in South India
Status: COMPLETED
Conditions: Infectious Gastroenteritis
Interventions: DIETARY_SUPPLEMENT: Lactobacillus GG|DIETARY_SUPPLEMENT: Inulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Study of Geriatric Patients Aged 75 Years or Older Treated and Cured for Localized Prostate Cancer: Case-control Study
Status: COMPLETED
Conditions: Prostate Cancer Cured|Healthy Population Control
Interventions: OTHER: geriatric assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Safety of Paxlovid in Hemodialysis Patients With Covid-19
Status: COMPLETED
Conditions: Safety Issues
Interventions: DRUG: Nirmatrelvir and ritonavir stage 1|DRUG: Nirmatrelvir and ritonavir stage 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Belimumab on Vaccine Responses in Subjects With Systemic Lupus Erythematosus (SLE)
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: Belimumab plus Early Vaccination|BIOLOGICAL: Belimumab plus Late Vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Corticotherapy in Megadoses to Treat Multiple Sclerosis During Relapse
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: methylprednisolone|DRUG: methylprednisolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Combination of Inotuzumab Ozogamicin and Lower Dose Chemotherapy Compared to Usual Chemotherapy for Adults With B-Cell Acute Lymphoblastic Leukemia or B-Cell Lymphoblastic Lymphoma
Status: RECRUITING
Conditions: B Acute Lymphoblastic Leukemia|B Lymphoblastic Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Vincristine|DRUG: Dexamethasone|BIOLOGICAL: Inotuzumab Ozogamicin|DRUG: Methotrexate|DRUG: Cytarabine|DRUG: Methylprednisolone|BIOLOGICAL: Rituximab|DRUG: Prednisone|DRUG: Mercaptopurine|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes of Children After Hospitalization in Intensive Care Unit
Status: NOT_YET_RECRUITING
Conditions: Renal Disease|Liver Diseases|Heart Diseases|Trauma Injury|Sepsis|Septic Shock|Pneumonia|Bronchiolitis
Interventions: OTHER: neurocognitive tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Quetiapine SR (Seroquel SR) to Treat SSRI-Resistant, Comorbid Panic Disorder Patients
Status: COMPLETED
Conditions: Panic Disorder
Interventions: DRUG: quetiapine XR|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Alpha-2 Macroglobulin Rich Plasma, Safety and Efficacy in Symptomatic Moderate Knee Osteoarthritis
Status: ENROLLING_BY_INVITATION
Conditions: Osteoarthritis|OA|Knee Osteoarthritis
Interventions: BIOLOGICAL: Autologous Alpha-2 Macroglobulin Rich Plasma (A2MRP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Several Anti-HIV Drug Combinations in HIV-Infected Patients Who Have Used Indinavir
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Ritonavir|DRUG: Nelfinavir mesylate|DRUG: Levocarnitine|DRUG: Adefovir dipivoxil|DRUG: Saquinavir|DRUG: Delavirdine mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Cerebrospinal Fluid Biomarkers in Bariatric Surgery
Status: RECRUITING
Conditions: Obesity
Interventions: PROCEDURE: Roux-en-Y Gastric Bypass (RYGB)|PROCEDURE: Sleeve Gastrectomy (SG)|BEHAVIORAL: Very Low Calorie Diet (VLCD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In-Utero Endoscopic Correction of Spina Bifida
Status: RECRUITING
Conditions: Neural Tube Defects|Spina Bifida|Myelomeningocele
Interventions: DEVICE: In Utero Endoscopic Correction of Myelomeningocele IDE - Percutaneous Technique|DEVICE: In Utero Endoscopic Correction of Myelomeningocele IDE - Laparotomy/Uterine Exteriorization Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of N-Acetylcysteine on Autologous Fat Graft Survival
Status: WITHDRAWN
Conditions: Adipose Tissue Atrophy|Deformity of Reconstructed Breast|Graft Loss
Interventions: DRUG: Acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eribulin Plus Cisplatin Versus Gemcitabine Plus Cisplatin in Triple Negative Breast Cancer (TNBC)
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Eribulin,cisplatin|DRUG: Gemcitabine,cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CKD-504 in SAD and MAD in Healthy Korean and Caucasian Adult Male and Female Subjects
Status: UNKNOWN
Conditions: Huntington Disease
Interventions: DRUG: CKD-504|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Vitamin D Deficiency in Type 1 Diabetes Mellitus and Effect of Supplementation on Insulin Requirements
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Compare How the Body Distributes and Excretes the Drugs Jivi (BAY 94-9027) and Adynovi in Patients With Severe Hemophilia A (Bleeding Disorder Resulting From a Lack of Blood Clotting Factor VIII)
Status: COMPLETED
Conditions: Hemophilia A
Interventions: BIOLOGICAL: Damoctocog-alfa-pegol (BAY94-9027, Jivi)|BIOLOGICAL: Rurioctocog alfa pegol (Adynovi)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study To Determine The Effects And Safety Of A Weight Loss Compound On Overweight, Otherwise Healthy, Volunteers
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: CP-866,087|DRUG: CP-866,087|DRUG: CP-866,087|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Prediction of Migraine Prevention Efficacy Based on Individual's Pain Modulation
Status: COMPLETED
Conditions: Migraine|Preventive Treatment
Interventions: DRUG: Amitriptyline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Prevention of Noise-induced Damage by Use of Antioxidants
Status: UNKNOWN
Conditions: Noise-induced Tinnitus|Noise-induced Hearing Loss
Interventions: DRUG: Antioxidantia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Minimally Invasive Lumbar Aneasthesia Used for Cesarean Section
Status: UNKNOWN
Conditions: Anticoagulation|Minimally Invasive|Spinal Anesthesia
Interventions: DEVICE: pen type 27 gauge needles|DEVICE: cutting type 22 gauge needles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Remineralization Potential of Self Assembling Peptide Combined With Fluoride
Status: UNKNOWN
Conditions: Caries; Initial
Interventions: COMBINATION_PRODUCT: Curodont Repair Fluoride Plus|OTHER: Bifluorid 10 fluoride varnish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single-dose Nicotine Pharmacokinetics With Three Oral Nicotine Replacement Products. A Study in Healthy Smokers.
Status: COMPLETED
Conditions: Tobacco Dependence
Interventions: DRUG: 6 mg Experimental nicotine gum|DRUG: 4 mg Nicotine Gum/|DRUG: 2 mg Nicotine Gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of a Sleep Hygiene Toolkit for Patients in ARU
Status: COMPLETED
Conditions: Sleep Disturbance|Sleep Disorder|Insomnia|Critical Illness Myopathy
Interventions: BEHAVIORAL: Sleep Hygiene Toolkit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: All Autologous Cartilage Regeneration in the Treatment of the Knee Cartilage Defects
Status: ACTIVE_NOT_RECRUITING
Conditions: Cartilage Damage|Cartilage Disease
Interventions: PROCEDURE: All Autologous Cartilage Regeneration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Liposome Encapsulated Mitoxantrone (LEM) in Patients With Advanced Cancer
Status: COMPLETED
Conditions: Tumors
Interventions: DRUG: Liposome Encapsulated Mitoxantrone (LEM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PROVIDENCE:Prevention of Restenosis With Oral Rosiglitazone and the Vision Stent in Diabetics With Coronary Lesions
Status: UNKNOWN
Conditions: Coronary Artery Disease|Diabetes Mellitus
Interventions: PROCEDURE: Percutaneous Coronary Intervention (PCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Guo's Aortic Arch Reconstruction :The Prospective ,Multiple Center Study About the Safety and Efficacy of WeFlow-Arch Modeler Embedded Branch Stent Graft System (GIANT Study)
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Arch Aneurysm
Interventions: DEVICE: WeFlow-Arch Modeler Embedded Branch Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Subjective and Objective Painful Threshold in Multiple System Atrophy Pain and Multiple System Atrophy
Status: COMPLETED
Conditions: Pain Threshold|Multiple System Atrophy
Interventions: DRUG: Levodopa test|PROCEDURE: determination of objective and subjective pain threshold
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Randomized Controlled Trial of VSL#3 for the Prevention of Endoscopic Recurrence Following Surgery for Crohn's Disease.
Status: COMPLETED
Conditions: Crohn's Disease|Inflammatory Bowel Disease
Interventions: DRUG: Probiotic - VSL#3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Incidence of Hospitalizations for Serious Infections in Patients Receiving Biologic Anti-Inflammatories for Rheumatologic, Psoriatic, and Gastrointestinal Conditions: A Descriptive Analysis
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Inflammatory Bowel Disease|Psoriasis|Psoriatic Arthritis|Ankylosing Spondylitis
Interventions: DRUG: TNF-α antagonists, non-TNFs, DMARD non-biologics
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of a Bolus of 10 µg/kg of Alfentanil on the Pupillary Pain Index
Status: COMPLETED
Conditions: Pain|Anesthesia
Interventions: DRUG: Alfentanil|DRUG: sevoflurane or propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence of Telmisartan/g Ramipril Fixed Dose Combination Compared With the Monocomponents Telmisartan and Ramipril (Two Different Formulations) Given Concomitantly to Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Telmisartan/Ramipril|DRUG: Telmisartan|DRUG: Ramipril capsule|DRUG: Ramipril tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes After Suprachoroidal Injection.
Status: UNKNOWN
Conditions: Retina; Change|Intraocular Pressure|Cataract|Macular Edema
Interventions: DRUG: Suprachoroidal triamcinolone acetonide (SCTA) injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transfer of Skills From VR-Trainer to Operation Room
Status: COMPLETED
Conditions: Clinical Competence
Interventions: BEHAVIORAL: LapSimGyn training until expert proficiency level is reached|BEHAVIORAL: Traditional clinical education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Substudy on the Mechanistic Plausibility of the Clinical Benefits of Adaptive Servo-ventilation
Status: COMPLETED
Conditions: Heart Failure|Sleep Disorder|Cheyne Stokes Respiration
Interventions: DEVICE: adaptive servoventilation (ASV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictive Proteomic Factors of the Response to Concomitant Radiochemotherapy in Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: PROCEDURE: Blood sampling|RADIATION: Radiation|DRUG: Chemotherapy (Fluorouracil and Cisplatin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Evidence-Based Psychological Treatment for Emotional Disorders Attended in Dominican Primary Care Units (PsicAP)
Status: UNKNOWN
Conditions: Anxiety Disorders|Depression|Somatic Disorders|Emotional Disorder
Interventions: BEHAVIORAL: PsicAP protocol|BEHAVIORAL: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Analisys of Neuromuscular Response, Postural Balance and Quality of Life of Diabetics Type 2 After Sensory-motor Training: Blind Random Controled Clinical Trial
Status: UNKNOWN
Conditions: Diabetes Mellitus|Quality of Life|Exercise Therapy|Postural Balance
Interventions: PROCEDURE: sensorio-motor training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aloe Vera and Chlorhexidine Against Traumatic Oral Ulcers
Status: COMPLETED
Conditions: Oral Ulcer
Interventions: DRUG: Antiseptic clorhexidine gel (Lacer, Barcelona, Spain)|DRUG: Master formula of aloe vera gel 80%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Therapeutic Approach to Diastolic Dysfunction in Chronic Liver Disease Patients and Its Impact on Morbidity and Mortality
Status: COMPLETED
Conditions: Diastolic Dysfunction|Chronic Liver Disease
Interventions: DRUG: Carvedilol|DRUG: Ivabradine|PROCEDURE: Endoscopic Variceal Ligation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Ambu AuraGain and Intersurgical i-Gel Laryngeal Masks in Elective Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Airway Management|Laryngeal Masks
Interventions: DEVICE: Oropharyngeal leak pressure during pneumoperitoneum.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Sunitinib Malate in Treating East African Patients With Kaposi Sarcoma
Status: WITHDRAWN
Conditions: AIDS-related Kaposi Sarcoma|Classic Kaposi Sarcoma
Interventions: DRUG: sunitinib malate|PROCEDURE: laboratory biomarker analysis|PROCEDURE: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Immunogenicity, Tolerability, and Safety of a New Formulation of RotaTeq™ in Infants (V260-035)
Status: COMPLETED
Conditions: Rotavirus Gastroenteritis
Interventions: BIOLOGICAL: RotaTeq™ experimental formulation|BIOLOGICAL: RotaTeq™ existing formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pemetrexed/Cisplatin Versus Gemcitabine/Cisplatin According to Thymidylate Synthase Expression
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Gemcitabine plus cisplatin|DRUG: pemetrexed plus cisplatin|DRUG: pemetrexed plus cisplatin|DRUG: Gemcitabine plus cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib Plus Doxorubicin in Patients With Advanced Hepatocellular Carcinoma With Disease Progression on Sorafenib
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Sorafenib|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Finding Study of BIRB 796 BS in Patients With Moderate to Severe Crohn's Disease
Status: TERMINATED
Conditions: Crohn Disease
Interventions: DRUG: Placebo|DRUG: BIBR 796 BS, 5 mg|DRUG: BIBR 796 BS, 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT