pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: tDCS-Augmented Exposure Therapy for Pathological Fear
Status: COMPLETED
Conditions: Specific Phobias
Interventions: DEVICE: Transcranial Direct Current Stimulation (tDCS)|BEHAVIORAL: In vivo exposure therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nutrition-dense Smoothie Diets Reduced Dysphagia Risk in the Elderly
Status: COMPLETED
Conditions: Dysphagia
Interventions: DIAGNOSTIC_TEST: the effect of consuming diets on the swallowing capacity by using Flexible Endoscopic Evaluation of Swallowing (FEES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Myocardial Stem Cell Administration After Acute Myocardial Infarction (MYSTAR) Study
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: PROCEDURE: Bone marrow-derived stem cells implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SNC115 Injections in Patients With Recurrent/Refractory Small Cell Lung Cancer and Lung Large Cell Neuroendocrine Carcinoma
Status: RECRUITING
Conditions: Recurrent/Refractory Small Cell Lung Cancer Lung Large Cell Neuroendocrine Carcinoma
Interventions: DRUG: SNC115 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Function in Older Veterans With Hospital-Associated Deconditioning
Status: COMPLETED
Conditions: Frail Elderly|Homebound Persons
Interventions: BEHAVIORAL: Progressive High Intensity Therapy (PHIT)|BEHAVIORAL: Usual Care (UC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy as First-Line Therapy in Treating Patients With Stage IV Gastric Cancer That Cannot Be Removed By Surgery
Status: TERMINATED
Conditions: Gastric Cancer
Interventions: DRUG: Docetaxel|DRUG: Floxuridine|DRUG: Leucovorin|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Whole Food Plant-Based Diet for HIV-Associated Reduction in Cardiovascular Risk (PLANT-HART)
Status: COMPLETED
Conditions: Heart Diseases|Hiv
Interventions: BEHAVIORAL: Whole Food Plant-Based Diet Ad Libitum|BEHAVIORAL: Nutritional Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Focused Shockwave Treatment in the Recovery Process of Acute Muscle Injuries in Soccer Players
Status: COMPLETED
Conditions: Muscle Injury
Interventions: DEVICE: F-ESW Treatment|DEVICE: Placebo F-ESW Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Digital Self-Management Program for Medicare Advantage Members With Type 2 Diabetes- Impact on A1c
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Diabetes Self-Management Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Family Training Program for Parents of Substance Using Adolescents
Status: COMPLETED
Conditions: Substance-Related Disorders|Drug Addiction|Substance Abuse
Interventions: BEHAVIORAL: Community Reinforcement and Family Training|BEHAVIORAL: Al-Anon Facilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: eSTEP: An Integrated mHealth Intervention to Engage High-risk Individuals Along the Full PrEP Care Continuum
Status: RECRUITING
Conditions: Pre-Exposure Prophylaxis (PrEP)
Interventions: BEHAVIORAL: eSTEP|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Manually Controlled Infusion vs Target Controlled Infusion for StrokeThrombectomy
Status: RECRUITING
Conditions: Stroke, Ischemic|Stroke/Brain Attack|Anesthesia|Hemodynamic Instability
Interventions: PROCEDURE: TCI|PROCEDURE: Manual induction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electrical Impedance Tomography (EIT) Monitoring in Adults With ALI or ARDS
Status: COMPLETED
Conditions: Acute Lung Injury (ALI)|ARDS
Interventions: DEVICE: Electrical Impedance Tomography monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: GRN-1201 With Pembrolizumab in Subjects With Metastatic PD-L1+ NSCLC
Status: TERMINATED
Conditions: Metastatic NSCLC
Interventions: BIOLOGICAL: GRN-1201 + Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study Comparing Signs and Symptoms in Patients With Ocular Hypertension or Glaucoma Using Xalatan R® or Travatan Z®
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: Xalatan|DRUG: Travatan Z
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Micellized Food Supplements on Health-related Quality of Life in Patients With Post-acute COVID-19 Syndrome.
Status: UNKNOWN
Conditions: Post-acute COVID-19 Syndrome
Interventions: DIETARY_SUPPLEMENT: Curcumin/Boswellia Serrata/Ascorbic acid mixture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protection of Autonomic Nervous System During Lower Spine Surgical Procedures: A Safety and Feasibility Study
Status: UNKNOWN
Conditions: Intervertebral Disc Degeneration|Intervertebral Disc Displacement|Spinal Curvatures|Spinal Stenosis|Spondylitis|Spondylosis|Osteoarthropathy, Primary Hypertrophic|Spinal Neoplasms
Interventions: DEVICE: Autonomic nervous system monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: DaunoXome + Ara-C vs Daunorubicin + Ara-C in Elderly AML
Status: COMPLETED
Conditions: AML|Elderly
Interventions: DRUG: DaunoXome|DRUG: Daunorubicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determine the Safety and Efficacy of Oxy/Nal Tablets Compared to Oxy PR in Subjects With Cancer Pain
Status: COMPLETED
Conditions: Cancer|Pain
Interventions: DRUG: Oxycodone/Naloxone|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Performance Study of the Legion Porous System in Total Knee Arthroplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Total Knee Arthroplasty
Interventions: DEVICE: LEGION Porous HA Tibial Baseplate and/or the LEGION Porous HA CR Femoral Component
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fatigue Interventions in Cancer (Exercise Intervention)
Status: COMPLETED
Conditions: Sedentary Lifestyle|Stage III Prostate Cancer AJCC v7|Stage IV Prostate Cancer AJCC v7
Interventions: BEHAVIORAL: Cognitive Behavior Therapy|BEHAVIORAL: Exercise Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Open Label, Ascending Dose Cohort Study of the Pharmacokinetics of Anti-Influenza Hyperimmune Intravenous Immunoglobulin in Healthy Subjects
Status: WITHDRAWN
Conditions: Influenza|Flu
Interventions: DRUG: Anti-influenza IVIG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of an Ankle Foot Orthosis With Anterior Support for Foot Drop
Status: COMPLETED
Conditions: Foot Drop
Interventions: DEVICE: New ankle foot orthosis with anterior support|DEVICE: Ankle foot orthosis with anterior support|DEVICE: Ankle foot orthosis from competitor 1|DEVICE: Ankle foot orthosis from competitor 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SVRd for the Treatment of Newly Diagnosed Multiple Myeloma Patients Presenting With Extramedullary Disease
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Selinexor|DRUG: Bortezomib|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MK-3475 in Combination With MRI-guided Laser Ablation in Recurrent Malignant Gliomas
Status: COMPLETED
Conditions: Malignant Glioma
Interventions: BIOLOGICAL: MK-3475|DEVICE: MRI-guided laser ablation|PROCEDURE: Surgical resection/debulking|PROCEDURE: Biopsy|PROCEDURE: Blood draw for research purposes|PROCEDURE: Cervical lymph node fine needle aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breast Cancer Survivors Who Experience Aromatase Inhibitor Associated Musculoskeletal Symptoms (AIMSS)
Status: RECRUITING
Conditions: Anatomic Stage 0 Breast Cancer AJCC v8|Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Hormone Receptor-Positive Breast Carcinoma
Interventions: OTHER: Non-Interventional Study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Annexin Imaging in Dissection of the Descending Aorta
Status: NOT_YET_RECRUITING
Conditions: Chronic Dissection of Thoracic Aorta (Disorder)
Interventions: DRUG: Annexin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Psilocybin and Spiritual Practice
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: psilocybin|BEHAVIORAL: Intensity of support for spiritual practice|BEHAVIORAL: Number of sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Copanlisib With Rituximab-Bendamustine in Patients With Relapsed-Refractory Diffuse Large B-cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: Copanlisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AC-1204 Long-term Efficacy Response Trial (ALERT Protocol)
Status: WITHDRAWN
Conditions: Alzheimer's Disease
Interventions: DRUG: caprylic triglyceride|DRUG: long-chain triglyceride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sleep Treatment Education Program-1 (STEP-1)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer Survivors|Insomnia
Interventions: BEHAVIORAL: Sleep Treatment Education Program (STEP-1)|BEHAVIORAL: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Propofol vs. Midazolam-based Balanced Propofol for Nonanesthesiologist Moderate Sedation in Colonoscopy
Status: COMPLETED
Conditions: Procedural Sedation
Interventions: DRUG: Midazolam|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of Parenterally Administrated Adjuvanted Seasonal Influenza Vaccine in Healthy Elderly Volunteers
Status: UNKNOWN
Conditions: Influenza
Interventions: BIOLOGICAL: Matrix M|BIOLOGICAL: Seasonal influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Idiopathic Thrombocytopenic Purpura (ITP) With Subcutaneously Administered Anti-D
Status: COMPLETED
Conditions: Idiopathic Thrombocytopenic Purpura
Interventions: DRUG: Anti-D
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 68Ga-NOTA-Aca-BBN(7-14) PET/CT in Patients With Primary Gliomas
Status: UNKNOWN
Conditions: Glioma
Interventions: DRUG: 68Ga-NOTA-Aca-BBN|DEVICE: PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Single and Multiple Ascending Dose Study to Assess Safety, Tolerability and Pharmacokinetics of NM-101
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: NM-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, and Efficacy of Vesatolimod in Combination With Tenofovir Disoproxil Fumarate (TDF) in Adults With Chronic Hepatitis B (CHB) Infection Who Are Currently Not Being Treated
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: TDF|DRUG: Vesatolimod|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Cord Stimulation for Restoration of Function in Lower-Limb Amputees, 90-Day
Status: RECRUITING
Conditions: Traumatic Amputation of Lower Extremity|Phantom Limb Pain
Interventions: DEVICE: Spinal cord stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Silodosin on Nocturia for Patients With Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Nocturia|Benign Prostatic Hyperplasia
Interventions: DRUG: Silodosin|OTHER: Laboratory tests|OTHER: 3-days voiding diary|OTHER: 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temozolomide vs. Temozolomide and Thalidomide Treatment in Recurrent Glioblastoma
Status: UNKNOWN
Conditions: Glioblastoma
Interventions: DRUG: Temozolomide|DRUG: Temozolomide plus Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tilsotolimod in Combination With Nivolumab and Ipilimumab for the Treatment of Solid Tumors (ILLUMINATE-206)
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: Tilsotolimod|DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inositol to Reduce Retinopathy of Prematurity
Status: TERMINATED
Conditions: Retinopathy of Prematurity (ROP)
Interventions: DRUG: myo-Inositol 5% Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prazosin Vibrostimulation Autonomic Dysreflexia and Spinal Cord Injury Study
Status: COMPLETED
Conditions: Autonomic Dysreflexia
Interventions: DRUG: Prazosin HCL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Insulin Detemir Morning, Insulin Detemir Evening and NPH Insulin Evening in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir|DRUG: insulin NPH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasonic Backscatter Imaging for ACL Reconstruction and Shoulder Diseases
Status: NOT_YET_RECRUITING
Conditions: ACL Injury|ACL Reconstruction
Interventions: PROCEDURE: ACL reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging
Status: RECRUITING
Conditions: Exercise Training|Aging
Interventions: BEHAVIORAL: Episodic Future Thinking|BEHAVIORAL: Episodic Recent Thinking|BEHAVIORAL: Positive Affective Imagery|BEHAVIORAL: Neutral Affective Imagery|BEHAVIORAL: HIIT Exercise Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of AOBO-001 for Overactive Bladder With Urge Urinary Incontinence and Frequency
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: AOBO-001|DRUG: AOBO-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Albumin-bound Paclitaxel and Carboplatin Versus Epirubicin and Docetaxel for Triple-negative Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Albumin-bound paclitaxel combined with carboplatin|DRUG: Epirubicin combined with docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Dose Steroid Therapy (Prednisone or Methylprednisolone) for the Improvement of Symptoms of Late Radiation-Associated Lower Cranial Neuropathy in Oropharyngeal Cancer Survivors
Status: RECRUITING
Conditions: Cranial Nerve Disorder|Head and Neck Carcinoma|Oropharyngeal Carcinoma
Interventions: DRUG: Methylprednisolone|DRUG: Prednisone|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Iron-fortified TPN on Preterm Infants Anemia
Status: UNKNOWN
Conditions: Preterm Infants
Interventions: OTHER: treatment group1|OTHER: treatment group2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Pharmacokinetics and Pharmacodynamics of Vibegron (MK-4618) in Women With Overactive Bladder (MK-4618-004)
Status: TERMINATED
Conditions: Overactive Bladder|Overactive Urinary Bladder
Interventions: DRUG: Vibegron|DRUG: Tolterodine ER|OTHER: Placebo (vibegron)|OTHER: Placebo (tolterodine ER)|DRUG: Prophylactic Antibiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise Program for Early Breast Cancer Survivors
Status: COMPLETED
Conditions: Stage I Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: OTHER: questionnaire administration|PROCEDURE: quality-of-life assessment|PROCEDURE: management of therapy complications|BEHAVIORAL: exercise intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Improving the Care of Diabetic Patients: A Randomized Trial of a Family Physician Office-Based Chronic Disease Care Model for Patients With Type 2 Diabetes
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: multidisciplinary approach|OTHER: multifactorial approach - for enhanced care group|OTHER: reflects current patterns of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Extracranial-intracranial Bypass Surgery for Symptomatic Chronic Middle Cerebral Artery Occlusion: the CMOSS-2 Trial
Status: RECRUITING
Conditions: Symptomatic Chronic Middle Cerebral Artery Occlusion|Infarction, Middle Cerebral Artery
Interventions: PROCEDURE: Extracranial-Intracranial Bypass Surgery|OTHER: Medical treatment alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Two Different Doses of Noradrenaline on Hypotension Caused by Spinal Anesthesia for Cesarean Section
Status: NOT_YET_RECRUITING
Conditions: Cesarean Section|Hypotension|Norepinephrine
Interventions: DRUG: Norepinephrine (0.1)|DRUG: Norepinephrine (0.075)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimising Diagnosis and Antibiotic Prescribing for Acutely Ill Children in Primary Care
Status: COMPLETED
Conditions: Sepsis|Bacteraemia|Meningitis|Abscess|Pneumonia|Osteomyelitis|Cellulitis|Gastro-enteritis With Dehydration|Complicated Urinary Tract Infection|Viral Respiratory Infection Complicated With Hypoxia
Interventions: DEVICE: Use of C-reactive protein (CRP) point of care test|OTHER: Brief intervention and parent leaflet|DEVICE: Finger Pulse Oximeter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Safety and Efficacy of Adalimumab in Subjects With Chronic Plaque Psoriasis and Nail Psoriasis
Status: COMPLETED
Conditions: Nail Psoriasis|Plaque Psoriasis
Interventions: BIOLOGICAL: Adalimumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Enhanced Provision of Male Circumcision (MC) for HIV Prevention, Rakai, Uganda
Status: COMPLETED
Conditions: Neonatal Male Circumcision
Interventions: PROCEDURE: Neonatal circumcision under topical anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Outcomes of Expanded Autologous Bone Marrow-derived Mesenchymal Stem Cells Therapy in Type II Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: COMBINATION_PRODUCT: Expanded autologous bone marrow-derived mesenchymal stem cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gait Retraining in Patients With Joint Hypermobility Syndrome/Hypermobile Ehlers Danlos Syndrome
Status: UNKNOWN
Conditions: Joint Hypermobility|Ehlers-Danlos Syndrome|Hyperextension Knees
Interventions: OTHER: Gait retraining program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Insulin Resistance in Idiopathic Oligospermia and Azoospermia
Status: COMPLETED
Conditions: Insulin Resistance|Oligospermia|Azoospermia
Interventions: OTHER: blood samples|OTHER: Blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pharmacokinetic (PK) Study of Three Types of E0302 Sustained Release (SR) Tablets Compared With E0302 Immediate Release (IR) Tablet Under Fed Conditions in Healthy Participants
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: E0302 SR1|DRUG: E0302 SR3|DRUG: E0302 SR2|DRUG: E0302 IR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Diosmin 600mg Versus Placebo on Painful Symptomatology in Patients With Chronic Venous Disease of Lower Limbs
Status: COMPLETED
Conditions: Chronic Venous Disease of Lower Limbs
Interventions: DRUG: Diosmin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Powered Prosthesis for Use With TF Osseointegration Recipients
Status: RECRUITING
Conditions: Amputation
Interventions: OTHER: Powered Prosthesis Training and EMG data collection|PROCEDURE: Perform Osseointegration (OI) surgery and Targeted Muscle Reinnervation (TMR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Molecular Markes of Fibrosis of Endometriosis and Their Use in Predicting Disease Severity
Status: RECRUITING
Conditions: Molecular Markers of Fibrosis of Single Types of Endometriosis and Their Use in Predicting Disease Severity
Interventions: OTHER: Molecular markes of fibrosis of single types of endometriosis and their use in predicting disease severity
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Progressive Relaxation Training Effect On Pain, Activity And Social Participation In Women With Tension-Type Headache And Migraine
Status: RECRUITING
Conditions: Pain, Chronic|Migraine Disorders|Tension-Type Headache
Interventions: OTHER: PROGRESSIVE RELAXATION TRAINING
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Macro- and Microvascular Response to Cocoa Flavanols in Healthy and Type 2 Diabetes
Status: COMPLETED
Conditions: Microangiopathy, Diabetic|Polyphenol|Optical Tomography|Vascular Endothelium|Arterial Stiffness|Healthy Participants
Interventions: DIETARY_SUPPLEMENT: Cocoa flavanol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Does the Bioactive Substance in Coffee, Cafestol, Have Preventive Properties on Type-2-diabetes? (Acute Substudy)
Status: COMPLETED
Conditions: Obesity, Abdominal
Interventions: DIETARY_SUPPLEMENT: Cafestol 12 mg|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Cafestol 6 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transforming Research and Clinical Knowledge in Traumatic Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: In-Person Outcome Assessment|BEHAVIORAL: Phone Outcome Assessment|PROCEDURE: 3T Magnetic Resonance Imaging (MRI)|PROCEDURE: Blood Draw for Plasma, DNA, Serum, RNA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Inferior Epigastric Lymp Node (IELN) Basin as a Possible Systemic Metastatic Pathway of Ovarian Peritoneal Metastases
Status: COMPLETED
Conditions: Carcinomatosis, Peritoneal
Interventions: PROCEDURE: epigastric lymph node biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Lateralized RTSA With and Without Subscapularis Repair
Status: RECRUITING
Conditions: Arthritis Shoulder
Interventions: PROCEDURE: RTSA with subscapularis repair|PROCEDURE: RTSA without subscapularis repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Inhaled PT001 in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Inhaled PT001|DRUG: Inhaled Placebo|DRUG: Tiotropium Handihaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Measuring Immune Resp, Activation in Foreskin/Mucosa in HIV-, Uncircumcised High-HIV-risk MSM, Lima Peru
Status: COMPLETED
Conditions: HIV Infections|Acquired Immunodeficiency Syndrome|Lentivirus Infections|Retroviridae Infections|RNA Virus Infections|Virus Diseases|Sexually Transmitted Diseases, Viral|Sexually Transmitted Diseases|Immunologic Deficiency Syndromes|Immune System Diseases|Slow Virus Diseases
Interventions: PROCEDURE: Circumcision|PROCEDURE: Flexible sigmoidoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy and Safety of Baclofen for Maintenance of Abstinence in Alcohol Dependent Patients
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: Baclofen|DRUG: Placebo (for baclofen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Yoga in Unipolar and Bipolar Disorders
Status: COMPLETED
Conditions: Bipolar Disorder|Major Depression|Dysthymia
Interventions: BEHAVIORAL: psychoeducation|BEHAVIORAL: Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effectiveness and Safety of Multiple Doses of Tapentadol(CG5503) in Patients Awaiting Joint Replacement Surgery
Status: COMPLETED
Conditions: Osteoarthritis|Pain Assessment|Arthralgia
Interventions: DRUG: CG5503 IR; tapentadol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Vasculopathic Injury and Plasma as Endothelial Rescue - OCTAplas Trial (EudraCT no. 2014-000452-28)
Status: COMPLETED
Conditions: Aortic Aneurysm, Thoracic|Endothelial Dysfunction
Interventions: DRUG: OctaplasLG®|BIOLOGICAL: Fresh frozen plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lotemax® Gel 0.5% and Restasis 0.05% in Participants With Mild or Moderate Keratoconjunctivitis Sicca (Dry Eye Disease)
Status: COMPLETED
Conditions: Keratoconjunctivitis Sicca
Interventions: DRUG: Lotemax|DRUG: Restasis|DRUG: Soothe® Lubricant Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Instant Messaging Reinforcement for Smoking Cessation Counseling Training
Status: ACTIVE_NOT_RECRUITING
Conditions: Smoking Cessation Counseling Ability|Smoking Cessation Counseling Practice
Interventions: OTHER: WhatsApp message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Nitric Oxide on the Endothelium During Hemolysis.
Status: RECRUITING
Conditions: Endothelial Dysfunction|Hemolysis Intravascular|Cardiovascular Diseases|Cardiovascular Risk Factor
Interventions: DRUG: Nitric Oxide|DIAGNOSTIC_TEST: Reactive Hyperemia Index|PROCEDURE: Endothelial Cells Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Health Promoting Work Schedules: The Effect of Abolishing Quick Returns
Status: UNKNOWN
Conditions: Sick Leave|Insomnia|Shift-Work Sleep Disorder|Psychological Distress|Work Accident|Turnover Intention|Work-family Spillover|Fatigue|Health, Subjective
Interventions: OTHER: Shift schedule without quick returns
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nutritional Supplementation and Insulin Sensitivity
Status: TERMINATED
Conditions: Nitric Oxide|Insulin Sensitivity|Vascular Function|L-arginine|Nitrate / Nitrite
Interventions: DIETARY_SUPPLEMENT: L-arginine + Nitrate / Nitrite|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Determining the Potential Benefit of Powered Prostheses
Status: COMPLETED
Conditions: Unilateral Traumatic Amputation|Amputation, Traumatic
Interventions: DEVICE: Powered ankle prosthesis|DEVICE: Dynamic Response Foot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Conventional ADT w/ or w/Out Abiraterone Acetate + Prednisone and Apalutamide Following a Detectable PSA After Radiation and ADT
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Prednisone|DRUG: Apalutamide|DRUG: Abiraterone Acetate|DRUG: LHRH Agonist or Antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection
Status: ACTIVE_NOT_RECRUITING
Conditions: Craniopharyngioma
Interventions: RADIATION: Proton Therapy|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of MDX-010 in Patients With Metastatic Hormone-Refractory Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Neoplasm Metastasis
Interventions: DRUG: MDX-010
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nexavar® Versus Placebo in Locally Advanced/Metastatic RAI-Refractory Differentiated Thyroid Cancer
Status: COMPLETED
Conditions: Thyroid Neoplasms
Interventions: DRUG: Sorafenib (Nexavar, BAY43-9006)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Multiple Doses and Regimens of XL184 (Cabozantinib) in Subjects With Grade IV Astrocytic Tumors in First or Second Relapse
Status: COMPLETED
Conditions: Astrocytic Tumors
Interventions: DRUG: XL184
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Analgesic Efficacy of Combined Transversus Abdominis Plane Block and Posterior Rectus Sheath Block in Patients Undergoing Laparoscopic Appendectomy"
Status: ACTIVE_NOT_RECRUITING
Conditions: ERAS
Interventions: DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare Meloxicam IM Once Daily Versus Meloxicam Orally Once Daily in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Meloxicam ampoule|DRUG: Meloxicam tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ga-68-CXCR4 PET/CT in Indolent B-cell Lymphoma
Status: RECRUITING
Conditions: Indolent B-Cell Non-Hodgkin Lymphoma
Interventions: DRUG: Ga-68-CXCR4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Nintedanib Per os as a Treatment for Epistaxis in HHT Disease.
Status: COMPLETED
Conditions: Telangiectasia, Hereditary Hemorrhagic|Rendu Osler Disease
Interventions: DRUG: Nintedanib 150 mg and 100 mg soft capsules|DRUG: Oral treatment of placebo soft capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Lesion Sterilization and Tissue Repair Techniques Versus Pulpectomy in Primary Molars With Inflammed Pulp
Status: RECRUITING
Conditions: Pulpitis - Irreversible
Interventions: PROCEDURE: Lesion Sterilization and Tissue Repair with radicular instrumentation|PROCEDURE: Lesion Sterilization and Tissue Repair without radicular instrumentation|PROCEDURE: Conventional pulpectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of IL-28B rs12979860 and rs4803217 Gene Polymorphisms Associated With miRNAs Deregulation on HCV-related Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: HCV Infection ( Genotype 4)
Interventions: BIOLOGICAL: IL28B Polymorphism|BIOLOGICAL: miRNA quantification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Avatrombopag for the Primary Prevention of Thrombocytopenia Induced by Cytarabine-based Chemotherapy in Patients With Lymphoma
Status: UNKNOWN
Conditions: Thrombocytopenia|Cytarabine Causing Adverse Effects in Therapeutic Use|Lymphoma
Interventions: DRUG: avatrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Prospective Clinical Study Evaluating Dexycu vs Prednisolone Acetate 1%
Status: COMPLETED
Conditions: Cataract
Interventions: DRUG: Dexycu intracameral dexamethasone|DRUG: Prednisolone Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The BEACON Study: Smartphone-Assisted Problem-Solving Therapy in Men Presenting to the ED With Self-Harm (Protocol A)
Status: WITHDRAWN
Conditions: Intentional Self-Harm|Suicide
Interventions: OTHER: Smartphone Assisted PST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Non-Interventional Follow Up Study For Subjects Who Received Sildenafil for Persistent Pulmonary Hypertension of the Newborn (PPHN)
Status: COMPLETED
Conditions: Pulmonary Hypertension, Persistent, of the Newborn
Interventions: OTHER: non-interventional
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate SU-VEID™ for Improving Peripheral Venous Access Success in Children
Status: TERMINATED
Conditions: Intravenous Access
Interventions: DEVICE: Single Use Vein Entry Indicator Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial to Evaluate the Efficacy and Safety of Tralokinumab in Combination With Topical Corticosteroids in Children and Infants With Moderate-to-severe Atopic Dermatitis
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: Tralokinumab + TCS|DRUG: Placebo + TCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of an Investigational Lozenge (Biofresh® 4plus) Versus Placebo Control on Oral Malodor (Intra-Oral Halitosis)
Status: COMPLETED
Conditions: Halitosis
Interventions: DIETARY_SUPPLEMENT: Biofresh® 4plus|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinical Evaluation of the Efficacy OF Botulinum Toxin A for Improving Facial Scars
Status: UNKNOWN
Conditions: Hypertrophic Scarring
Interventions: DRUG: AbobotulinumtoxinA 500 UNT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Implementation and Evaluation of Primary Care Behavioral Health in Sweden
Status: RECRUITING
Conditions: Psychological Distress|Life Style Induced Illness|Life Stress|Mental Health Disorder
Interventions: BEHAVIORAL: Brief Interventions (BI)|BEHAVIORAL: Care As Usual (CAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study Between Bakri Balloon and B Lynch Suture Used to Control Primary Postpartum Hemorrhage After Cesarean Section
Status: UNKNOWN
Conditions: Post Partum Hemorrhage
Interventions: PROCEDURE: B-Lynch|PROCEDURE: BALLOON INSERTION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycemic Effect of Diazoxide in NAFLD
Status: RECRUITING
Conditions: Hyperinsulinemia|Insulin Resistance|Non-Alcoholic Fatty Liver Disease|Prediabetic State
Interventions: DRUG: Diazoxide oral suspension, 1 mg per kg per dose|DRUG: Diazoxide oral suspension, 2 mg per kg per dose|DRUG: Placebo|DEVICE: FreeStyle Libre Pro|DRUG: Deuterated water (2H2O/D2O)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Single-operator Digital Cholangioscopy for the Diagnosis of Malignant and Benign Biliary Strictures
Status: RECRUITING
Conditions: Biliary Stricture
Interventions: DEVICE: SpyGlass DS Cholangioscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Investigate Safety, Tolerability, PK, PD and Efficacy of Risdiplam (RO7034067) in Infants With Type1 Spinal Muscular Atrophy
Status: COMPLETED
Conditions: Muscular Atrophy, Spinal
Interventions: DRUG: Risdiplam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parent-Child Interaction Therapy (PCIT) for Children With Traumatic Brain Injury (TBI): A Stepped-Care Model
Status: NOT_YET_RECRUITING
Conditions: Traumatic Brain Injury|Disruptive Behavior
Interventions: BEHAVIORAL: PCIT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Placebo Controlled 4 Week Proof of Concept Study With 0.5% Roflumilast Cream in Patients With Mild Atopic Dermatitis (RO-2351-001-EM)
Status: WITHDRAWN
Conditions: Dermatitis
Interventions: DRUG: Roflumilast cream|DRUG: Placebo cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Cohort of Spinal Stereotactic Radiotherapy in Patients Using a MR LINAC
Status: RECRUITING
Conditions: Spinal Disease
Interventions: PROCEDURE: Spine Radiosurgery|DEVICE: Magnetic Resonance imaging|RADIATION: MR-LINAC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Intensive Chemotherapy With or Without Volasertib in Patients With Newly Diagnosed High-Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)
Status: TERMINATED
Conditions: Acute Myeloid Leukemia (AML)|High-risk Myelodysplastic Syndrome (MDS)
Interventions: DRUG: Volasertib|DRUG: Cytarabine|DRUG: Daunorubicin|DRUG: Mitoxantrone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pirfenidone in the Chronic Hypersensitivity Pneumonitis Treatment
Status: UNKNOWN
Conditions: Alveolitis Extrinsic Allergic|Pulmonary Fibrosis
Interventions: DRUG: Placebo|DRUG: Pirfenidone|DRUG: Pirfenidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of BackStop in Patients Undergoing Intraureteric Stone Lithotripsy
Status: COMPLETED
Conditions: Renal Calculi|Kidney Stones
Interventions: DEVICE: BackStop|DEVICE: Intracorporeal lithotripsy without the use of an anti-retropulsion device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pulsed Radiofrequency Versus Pulse Dose Pulsed Radiofrequency of the Pudendal Nerve in Patients With Pudendal Neuralgia
Status: UNKNOWN
Conditions: Pain, Chronic
Interventions: DEVICE: conventional pulsed radiofrequency|DEVICE: pulse dosed pulsed radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sex-Differential Health Interventions In Low-Birth-Weight Infants
Status: COMPLETED
Conditions: Mortality|Morbidity|Growth|Neonatal Mortality
Interventions: BIOLOGICAL: OPV|BIOLOGICAL: OPV plus BCG|BIOLOGICAL: OPV|BIOLOGICAL: OPV plus BCG
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Study of CEP-701 (Lestaurtinib) in Patients With Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: CEP-701|DRUG: high-dose cytarabine|DRUG: Mitozantrone, Etoposide, Cytarabine (combination Chemotherapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of a New 1-piece Convex Ostomy Product
Status: COMPLETED
Conditions: Stoma Ileostomy|Stoma Colostomy
Interventions: DEVICE: Coloplast Test|DEVICE: Own product|DEVICE: Competitor soft convex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE