pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Clinical Trial of ACYW135 Group Meningococcal Polysaccharide Conjugate Vaccine (CRM197 Vector) in 18-59 Year Olds
Status: ACTIVE_NOT_RECRUITING
Conditions: Meningococcal Meningitis
Interventions: BIOLOGICAL: MCV4|BIOLOGICAL: MPSV4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess Fixed Dosing of AMG 223 in Subjects With Chronic Kidney Disease on Hemodialysis With Hyperphosphatemia
Status: COMPLETED
Conditions: End Stage Renal Disease|Chronic Kidney Disease|Hyperphosphatemic|Kidney Disease
Interventions: DRUG: AMG 223|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Study Between Cefdinir & Amoxicilline/Clavulanate in Acute Sinusitis and Assessment of Quality of Life
Status: COMPLETED
Conditions: Acute Bacterial Sinusitis
Interventions: DRUG: Cefdinir (drug)|DRUG: amoxicillin/clavulanate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of BI 207127 Trial Formulation II Prototypes Versus BI 207127 Trial Formulation I in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 207127 NA (TF-I)|DRUG: BI 207127 NA (TF-II)|DRUG: BI 207127 NA delayed release|DRUG: BI 207127 NA extended release (10% HPMC)|DRUG: BI 207127 NA extended release (15% PEO)|DRUG: BI 207127 NA extended release (20% HPMC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Alternative Prosthetic Alignments on Sit-to-Stand Proficiency in Transtibial Amputees
Status: COMPLETED
Conditions: Amputation Balance Prosthesis
Interventions: OTHER: Neutral Alignment|OTHER: Anterior Alignment|OTHER: Posterior Alignment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Determining the Minimum Effective Volume of Local Anesthetic for Ultrasound-guided Axillary Brachial Plexus Block
Status: COMPLETED
Conditions: Axillary Brachial Plexus Block
Interventions: OTHER: Bupivacaine 0,5%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Critical Care Results of SARS-CoV-2 ARDS by Dapsone and Standard COVID-19 Treatment
Status: UNKNOWN
Conditions: SARS-CoV-2|Hypoxia|ARDS
Interventions: DRUG: Dapsone 100 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultibro® Versus Spiriva® Alone to Reduce Exertional Dyspnea in Patients With Moderate to Severe COPD
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Ultibro®|DRUG: Spiriva®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy With Carfilzomib, Romidepsin, Lenalidomide in Patients With Relapsed or Refractory B- and T-cell Lymphomas
Status: COMPLETED
Conditions: T-cell Lymphomas|Relapsed or Refractory
Interventions: DRUG: Carfilzomib|DRUG: Romidepsin|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Topical NVC-422 Gel in Impetigo
Status: COMPLETED
Conditions: Impetigo
Interventions: DRUG: NVC-422
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ticagrelor and Peripheral Arterial Disease
Status: TERMINATED
Conditions: Peripheral Arterial Disease
Interventions: PROCEDURE: Percutaneous Peripheral Intervention|DEVICE: Optical Coherence Tomography|OTHER: Ankle Brachial Index|OTHER: Six minute walk distance|DRUG: Aspirin|DRUG: Aspirin + Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients
Status: RECRUITING
Conditions: End Stage Renal Disease|Hypertension|Extracellular Volume Overload|Intradialytic Hypotension
Interventions: OTHER: IBPS-Guided Ultrafiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of OM-89 in Patients With Recurrent Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Status: RECRUITING
Conditions: Chronic Prostatitis With Chronic Pelvic Pain Syndrome|Chronic Prostatitis|Chronic Pelvic Pain Syndrome
Interventions: DRUG: OM-89 [Uro-Vaxom® Capsule]|DRUG: OM-89 Placebo [Uro-Vaxom® Capsule Placebo]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Anesthetic Effectiveness of Buffered Articaine Injected Next to a Lower First Molar.
Status: COMPLETED
Conditions: Anesthetic Effectiveness
Interventions: DRUG: Articaine Hydrochloride + Epinephrine|DRUG: Buffered Articaine Hydrochloride + Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of SNPs in the BCMO1 Enzyme
Status: COMPLETED
Conditions: Beta-carotene Bioavailability|Vitamin A Deficiency
Interventions: DIETARY_SUPPLEMENT: Beta-carotene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Stent Implantation in Symptomatic Extra- and Intracranial Artery Stenosis
Status: COMPLETED
Conditions: Stroke|Transient Ischemic Attack|Atherosclerosis|Stenosis|Stents
Interventions: DEVICE: Stent implantation (Wingspan, Coroflex, and TiTAN2)|DRUG: Standard medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Concomitant Chemo-radiotherapy With Cisplatine vs Gemcitabin in Locally Advanced Cervicouterine Cancer
Status: RECRUITING
Conditions: Locally Advanced Cervical Cancer|Gemcitabine|Chemo-radiotherapy
Interventions: DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritional Supplement Based on Myo-inositol-D-chiro-inositoln in Long-term Survivors of Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Hodgkin|Menstrual Irregularity|Fertility Disorders
Interventions: DRUG: Myo-Inositol and D-Chiro-Inositol (MIC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase I, Autologous ex Vivo Expanded and Activated NK Cell, Magicell-NK, Infusion for Colon Cancer Post Resection Study
Status: RECRUITING
Conditions: Colon Cancer Stage I
Interventions: BIOLOGICAL: Magicell-NK contains NK cells suspended in 100 mL normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Norepinephrine Versus Fresh Frozen Plasma in Patients Undergoing HIPEC to Reduce Renal Insult
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Norepinephrine|BIOLOGICAL: Fresh frozen plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Median Nerve Stimulation Pilot
Status: COMPLETED
Conditions: Tourette Syndrome|Tic Disorders|Tic Disorder, Chronic Motor or Vocal
Interventions: DEVICE: Rhythmic median nerve stimulation|DEVICE: Arrhythmic median nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SAD and MAD of Inhaled AR-501 in Health Adults and P. Aeruginosa Infected Cystic Fibrosis Subjects
Status: RECRUITING
Conditions: Cystic Fibrosis
Interventions: DRUG: Inhaled AR-501|DRUG: Inhaled Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Imaging of Muscle Structure in Duchenne Muscular Dystrophy Using Multispectral Optoacoustic Tomography
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy|Muscular Dystrophies|Muscular Dystrophy, Duchenne
Interventions: DEVICE: Multispectral Optoacoustic Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Attention-deficit/Hyperactivity Disorder Translational Center for Identifying Biomarkers
Status: UNKNOWN
Conditions: Attention-deficit/Hyperactivity Disorder
Interventions: DRUG: methylphenidate|DRUG: atomoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prediction of Relapse Risk in Stable Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: OTHER: Drug free|DRUG: HCQ|DRUG: GC+HCQ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of 8 Weeks of Digital Meditation Application and Healthy Eating Program on Work Stress and Health Outcomes
Status: COMPLETED
Conditions: Stress|Psychological|Behavioral Symptoms|Sleep|Health Behavior|Weight, Body
Interventions: BEHAVIORAL: Meditation|BEHAVIORAL: Healthy Eating|BEHAVIORAL: Meditation + healthy eating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Balloon Dilation of the Eustachian Tubes Under Local Anesthesia
Status: UNKNOWN
Conditions: Chronic Eustachian Salpingitis
Interventions: DEVICE: Balloon dilation of the Eustachian tubes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adaptive Individualized High-Dose Radiotherapy Analysis-REctum-1 (AIDA-RE-1)
Status: UNKNOWN
Conditions: Rectal Cancer|Radiotherapy|Neoadjuvant Treatment
Interventions: RADIATION: IMRT-SIB plus sequential IG-RT boost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hospital at Home for Elderly Acute Ill Patients
Status: RECRUITING
Conditions: Cystitis|Erysipelas|Pneumonia
Interventions: OTHER: Hospital at Home (HaH) treatment|OTHER: Standard hospital admission
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Same-day Dilapan-S With Adjunctive Misoprostol
Status: TERMINATED
Conditions: Therapeutic Abortion
Interventions: DRUG: Misoprostol|DRUG: Folic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: International Study for Treatment of Standard Risk Childhood Relapsed ALL 2010
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia (ALL)
Interventions: DRUG: SR-A + Epratuzumab|DRUG: SR-B + Epratuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Change in Cardiovascular Health
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: GENETIC: Disclosure of high polygenic risk result for coronary artery disease
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Measurement of Anterior Chamber Cell Grading Using Ocular Coherence Tomography
Status: TERMINATED
Conditions: Uveitis
Interventions: DEVICE: Optical Coherence Tomography (OCT)|OTHER: Eye Exam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Transcranial Doppler, Optic Nerve Envelope Diameter and Quantitative Pupillometry Measurements
Status: RECRUITING
Conditions: Neurological Complication
Interventions: OTHER: Non-invasive neuromonitoring evaluation (transcranial doppler, optic nerve envelope diameter and quantitative pupillometry)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Steroid for the Postoperative Swelling After Orthognathic Surgery
Status: COMPLETED
Conditions: Swelling
Interventions: DRUG: Dexamethasone"low-dose"|DRUG: Dexamethasone"high-dose"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Evaluation of T.R.U.E. TEST® : Safety and Efficacy
Status: COMPLETED
Conditions: Contact Dermatitis
Interventions: BIOLOGICAL: T.R.U.E. TEST® Skin Patch Test: Dose Response Allergens
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treatment Response of Maintenance Dose of Proton Pump Inhibitor in Patients With Nonerosive Gatroesophageal Reflux Disease
Status: COMPLETED
Conditions: Non-erosive Gatroesophageal Reflux Disease
Interventions: DRUG: PPI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Autologous Adipose-Derived Stem/Stromal Cells (AD-cSVF) in Symptomatic Benign Prostate Hypertrophy
Status: WITHDRAWN
Conditions: BPH|Nocturia|BPH With Urinary Obstruction|Prostatism|Prostate Inflammation
Interventions: PROCEDURE: Microcannula Harvest Adipose|DEVICE: Centricyte 1000|BIOLOGICAL: IV Sterile Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relief of Symptoms of Post-traumatic Stress for Victims of Gun Violence
Status: COMPLETED
Conditions: PTSD|Stress, Psychological|Gunshot Wound
Interventions: BEHAVIORAL: Screening Tool for Relief of Trauma (START)|BEHAVIORAL: standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Survival and Dialysis Independency in Highly Sensitized Patients After Desensitization With Imlifidase and Tx of Kidneys
Status: RECRUITING
Conditions: Kidney Transplantation in Highly Sensitized Patients
Interventions: DRUG: Imlifidase administered in the ConfIdeS study|OTHER: Best available treatment administered in the ConfIdeS study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Verubulin, Radiation Therapy, and Temozolomide to Treat Patients With Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Verubulin|DRUG: Temozolomide & Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ONE-1 Oral graNd Est 1
Status: UNKNOWN
Conditions: Dental Decay|Periodontal Abscess|Periodontitis|Gingivitis|Dental Plaque|Calculus, Dental|Missing Teeth
Interventions: DEVICE: Intra oral cameras
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Raja Isteri Pengiran Anak Saleha Appendicitis Treatment Without Operation
Status: TERMINATED
Conditions: Appendicitis|Surgery
Interventions: DRUG: Amikacin Injection|PROCEDURE: Appendicectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of Teaching Method With Simulation in Electronic Fetal Monitoring Management
Status: RECRUITING
Conditions: Cardiotocography|Electronic Fetal Monitoring|High Fidelity Simulation Training
Interventions: BEHAVIORAL: Simulation training in electronic fetal monitor management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Dyadic Approach for a Remote Physical Activity Intervention in Adults With AD and Their Caregivers
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: BEHAVIORAL: Real-time Group Video|BEHAVIORAL: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Safety/Efficacy Study of Intracoronary Integrilin to Improve Balloon Angioplasty Outcomes for the Treatment of Heart Attacks
Status: TERMINATED
Conditions: ST-Elevation Myocardial Infarction
Interventions: DRUG: eptifibatide|DRUG: eptifibatide|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobilization With Neuromuscular Electrical Stimulation in Critical Care Patients
Status: UNKNOWN
Conditions: Muscular Atrophy
Interventions: DEVICE: NEUROMUSCULAR ELECTRICAL STIMULATION|OTHER: Conventional physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fire Dragon Pot Moxibustion
Status: COMPLETED
Conditions: Insomnia|Perimenopause
Interventions: OTHER: Traditional Chinese Medicine auricular acupuncture point buried seeds therapy plus the fire dragon pot moxibustion therapy.|OTHER: Traditional Chinese Medicine auricular acupuncture point buried seeds therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Aflibercept in Treating Young Patients With Relapsed or Refractory Solid Tumors
Status: COMPLETED
Conditions: Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: ziv-aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3461767 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3461767 - SC|DRUG: LY3461767 - IV|DRUG: Placebo - SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Medical and Endovascular Treatment of Atherosclerotic Renal Artery Stenosis (METRAS Study)
Status: UNKNOWN
Conditions: Renal Artery Stenosis
Interventions: DRUG: Optimal medical therapy|PROCEDURE: revascularization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paresthesia-free Peripheral Nerve Field Stimulation for Trigeminal Neuralgia (FreeST Trial)
Status: RECRUITING
Conditions: Trigeminal Neuralgia|Facial Pain
Interventions: OTHER: Paresthesia-free Peripheral Nerve Field Stimulation|OTHER: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuropsychiatric Scleroderma Study: Systematic Evaluation of Neuropsychiatric Involvement in Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis
Interventions: OTHER: Magnetic resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Medication Adherence in Patients With Inflammatory Bowel Disease (IBD)
Status: COMPLETED
Conditions: Inflammatory Bowel Disease|Crohn's Disease|Ulcerative Colitis
Interventions: BEHAVIORAL: Education and Reminders|BEHAVIORAL: Educational Visit|BEHAVIORAL: Medication Educational Visit|BEHAVIORAL: Financial Support
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy Study of GRT6005 in Patients With Osteoarthritis (OA) Knee Pain
Status: COMPLETED
Conditions: Moderate to Severe Chronic Pain Due to Osteoarthritis of the Knee
Interventions: DRUG: Cebranopadol (GRT6005) Low-Dose Range|DRUG: Cebranopadol (GRT6005) High-Dose Range|DRUG: Placebo|DRUG: Oxycodone CR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate Pharmacological Interactions Between γ-hydroxybutyrate (GHB) and Cobicistat
Status: COMPLETED
Conditions: Pharmacokinetic Interactions|HIV
Interventions: DRUG: Cobicistat 150 MG|DRUG: Placebo|DRUG: GHB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: PK Study of Multi-dose Trazodone Hydrochloride Prolonged-released Tablets in Healthy Chinese
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: trazodone hydrochloride prolonged-release tablet|DRUG: trazodone hydrochloride tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Testing of Collagen Drink on Skin Beauty and Sleep Aid
Status: COMPLETED
Conditions: Skin Condition|Sleep Disturbance
Interventions: DIETARY_SUPPLEMENT: Placebo drink|DIETARY_SUPPLEMENT: Collagen Juice Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Interpretation of Health News Items Reporting Results of Pre-clinical Studies With or Without Spin By English-speaking Population
Status: WITHDRAWN
Conditions: The Study Focus on no Specific Condition
Interventions: OTHER: News items with spin|OTHER: News items without spin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Humanized Anti-CD25 Antibody for Prophylaxis of aGVHD in Elderly Underwent HID-HSCT
Status: NOT_YET_RECRUITING
Conditions: The Effecacy and Safety of Humanized CD25 Antibody in aGVHD Prophylaxis Among Elderly Patients After HID-HSCT
Interventions: DRUG: CD25 prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study Determining the Pain Response, Functional Interference and Quality of Life in Patients Undergoing Radiofrequency Ablation Assisted Vertebroplasty/ Cementoplasty
Status: COMPLETED
Conditions: Neoplasms|Cementoplasty|Quality of Life
Interventions: PROCEDURE: RFA Vertebroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Antero-posterior Versus Antero-lateral Electrode Position for Electrical Cardioversion of Typical Atrial Flutter
Status: TERMINATED
Conditions: Atrial Flutter
Interventions: PROCEDURE: external electrical cardioversion (with antero-posterior electrode position)|PROCEDURE: external electrical cardioversion (with antero-lateral electrode position)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Double-blind RCT of a Single Dose of Hyaluronan in the Treatment of Osteoarthritis of the Ankle
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: hyaluronate intra-articular injection|DEVICE: placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Randomized Control Trial Comparing Immediate and 24-hours Delayed Catheter Removal Following Hysterectomy
Status: COMPLETED
Conditions: Hysterectomy
Interventions: PROCEDURE: immediate removal of in-dwelling catheter|PROCEDURE: 24 hours delayed removal of catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Justify Steroid Use in Preterm Neonates to Prevent Bronchopulmonary Dysplasia
Status: UNKNOWN
Conditions: Bronchopulmonary Dysplasia
Interventions: DRUG: Dexamethasone (Steroids)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamics, Safety and Pharmacokinetics of BMS-663068, an HIV Attachment Inhibitor, in HIV-1
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: BMS-663068|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label, Phase 1b Study of Acalabrutinib With and Without Dexamethasone in Subjects With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma (MM)
Interventions: DRUG: acalabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Effect of 500 mg Oral Dose of KD025 in Healthy Male and Post-menopausal Female Subjects
Status: COMPLETED
Conditions: Immune System Disorder (Healthy Volunteer)
Interventions: DRUG: Belumosudil mesylate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Leronlimab (PRO 140) in Patients With Nonalcoholic Steatohepatitis
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis (NASH)
Interventions: DRUG: Placebo|DRUG: leronlimab 700 mg|DRUG: leronlimab 350 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Denileukin Diftitox in Treating Patients With Metastatic Melanoma or Metastatic Kidney Cancer
Status: COMPLETED
Conditions: Kidney Cancer|Melanoma (Skin)
Interventions: BIOLOGICAL: denileukin diftitox
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Convalescent Plasma in the Treatment of SARS CoV-2 Disease (COVID-19) With Evaluation of Therapy Effectiveness
Status: TERMINATED
Conditions: COVID-19 Convalescent Plasma Treatment
Interventions: BIOLOGICAL: COVID-19 convalescent plasma treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Oral Probiotic Supplementation on the Clinical Status of Very-low-birth-weight Preterm Neonates.
Status: COMPLETED
Conditions: Late Onset Neonatal Sepsis|Necrotizing Enterocolitis|Infant, Very Low Birth Weight
Interventions: OTHER: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Adjuvant Chemoradiation Therapy for Gastric or Gastroesophageal Junction Adenocarcinoma
Status: COMPLETED
Conditions: Stomach Cancer|Gastric Cancer|Gastro-esophageal Junction Cancer
Interventions: DRUG: Epirubicin|DRUG: Cisplatin|DRUG: 5-Fluorouracil (5-FU)|PROCEDURE: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastatic Non-small Cell Lung Cancer
Interventions: DRUG: Dato-DXd|DRUG: Osimertinib|DRUG: Pemetrexed|DRUG: Carboplatin|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Social Risk Factors and Discrimination in Cancer Survivorship
Status: RECRUITING
Conditions: Social Determinants of Health|Breast Cancer|Prostate Cancer|Health Equity|Disparities
Interventions: BEHAVIORAL: Community Health Worker support
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Study of Ganoderma Lucidum Spore Combined With Chemotherapy
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Ganoderma lucidum spore|DRUG: Placebo|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety of Remsima® SC in the Treatment of RA, AS, PsA and Ps
Status: RECRUITING
Conditions: Rheumatoid Arthritis|Ankylosing Spondylitis|Psoriatic Arthritis|Psoriasis
Interventions: DRUG: Remsima IV|DRUG: Remsima SC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessing the Gut Microbiome and Its Association With Pediatric Stress and Cognition
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Adverse Childhood Experiences|Stress Reaction
Interventions: DIETARY_SUPPLEMENT: Probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Glucocorticoid Treatment for Social Phobia
Status: TERMINATED
Conditions: Phobic Disorders|Phobias
Interventions: BEHAVIORAL: CBGT|DRUG: Hydrocortisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Aspen Spinous Process System in Anterior Lumbar Interbody Fusion (ALIF)
Status: WITHDRAWN
Conditions: Degenerative Disc Disease
Interventions: DEVICE: Aspen Spinous Process System|DEVICE: Pedicle Screw Fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketogenic Diets as an Adjuvant Therapy in Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma|Glioblastoma Multiforme|Glioblastoma, Adult
Interventions: OTHER: MKD|OTHER: MCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of CF102 in the Treatment of Non-Alcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Non-alcoholic Steatohepatitis (NASH)
Interventions: DRUG: CF102|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Chiropractic Adjustments on Brain Function Using Quantitative Encephalography
Status: COMPLETED
Conditions: Brain Function
Interventions: OTHER: Chiropractic adjustment|OTHER: Sham adjustment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of NT-112 in HLA-C*08:02-Positive Adult Subjects With Unresectable, Advanced, and/ or Metastatic Solid Tumors Positive for the KRAS G12D Mutation
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer|Colorectal Carcinoma|Pancreatic Ductal Adenocarcinoma|Endometrial Cancer|Solid Tumor, Adult|KRAS G12D
Interventions: BIOLOGICAL: NT-112: Autologous, engineered T Cells targeting KRAS G12D
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Immunonutrition (Impact Oral®) in Patients Undergoing Surgery for Gastrointestinal Cancer
Status: COMPLETED
Conditions: Gastrointestinal Cancer
Interventions: OTHER: Impact Oral|OTHER: Enteral Nutrition Emulsion(TPF-T)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fasting Study of Olmesartan Medoxomil and Hydrochlorothiazide Tablets 40 mg/25 mg and Benicar HCT® Tablets 40 mg/25 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Olmesartan Medoxomil and Hydrochlorothiazide Tablets 40 mg/25 mg|DRUG: Benicar HCT® Tablets 40 mg/25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Single-Arm Study of Aflibercept 8 mg Dosed in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD) or Diabetic Macular Edema (DME)
Status: RECRUITING
Conditions: Neovascular Age-Related Macular Degeneration|Diabetic Macular Edema
Interventions: DRUG: Aflibercept 8 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcatheter Arterial Embolization for Elbow and Foot Plantar Pain
Status: RECRUITING
Conditions: Elbow Tendinitis|Elbow Tendinopathy|Epicondylitis of the Elbow|Epicondylitis, Lateral|Plantar Fascitis|Embolization
Interventions: DEVICE: Transcatheter Arterial Embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Metronidazole and Miconazole Co-formulated Vaginal Suppositories for Preventing Vaginal Infections in HIV-seronegative Women
Status: COMPLETED
Conditions: Bacterial Vaginosis|Candidiasis|Trichomoniasis
Interventions: DRUG: Neo-Penotran® Forte (active ingredient Metronidazole & Miconazole Nitrate)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Epidural Morphine Following Vaginal Delivery
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Preservative-free epidural morphine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Randomized Trial of Vitamin D to Reduce Respiratory Infection
Status: COMPLETED
Conditions: Respiratory Infection
Interventions: DIETARY_SUPPLEMENT: vitamin D supplements|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Repeat of: A Study to Evaluate Efficacy and Safety of Sublingual TNX-102 SL Tablet Taken at Bedtime in Patients With Fibromyalgia
Status: TERMINATED
Conditions: Fibromyalgia|Myofascial Pain Syndromes|Muscular Diseases|Nervous System Diseases|Neuromuscular Diseases|Rheumatic Diseases|Musculoskeletal Diseases
Interventions: DRUG: TNX-102 SL Tablet, 2.8 mg|DRUG: Placebo SL Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Production of Lipoproteins and Acetyl-CoA During a Ketogenic Diet
Status: COMPLETED
Conditions: Cholesterol Metabolism|Ketone Metabolism
Interventions: OTHER: Standard American diet|OTHER: Very low carbohydrate diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Comparative Study of Combination Antiretroviral Therapy in Children and Adolescents With Advanced HIV Disease
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Nevirapine|DRUG: Zidovudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety Study of ASONEP (Sonepcizumab/LT1009) to Treat Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: BIOLOGICAL: ASONEP (sonepcizumab/LT1009)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain and Smoking Study - Interactive Voice Response
Status: NOT_YET_RECRUITING
Conditions: Smoking|Pain|Smoking Cessation
Interventions: BEHAVIORAL: PASS-IVR|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Alisporivir for the Treatment of Hospitalised Patients With Infections Due to SARS-CoV-2 (COVID-19)
Status: COMPLETED
Conditions: SARS-CoV-2
Interventions: DRUG: Alisporivir|OTHER: Standard of care (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Levetiracetam XR in Very Heavy Drinkers
Status: COMPLETED
Conditions: Alcoholism
Interventions: BEHAVIORAL: BBCET|BEHAVIORAL: BBCET|DRUG: Levetiracetam XR|DRUG: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Winged Perimeter Versus Traditional Plastic Biliary Stent for Malignant Bile Duct Obstruction
Status: COMPLETED
Conditions: Malignant Tumor of Extrahepatic Bile Duct
Interventions: DEVICE: WInged perimeter biliary stent insertion (Viaduct)|DEVICE: traditional polyethylene stent insertion (Cotton Huibregtse)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sulopenem Followed by Sulopenem-etzadroxil/Probenecid vs Ertapenem Followed by Cipro for Complicated UTI in Adults
Status: COMPLETED
Conditions: Complicated Urinary Tract Infections
Interventions: DRUG: Sulopenem|DRUG: Sulopenem-Etzadroxil/Probenecid|DRUG: Ertapenem|DRUG: Ciprofloxacin|DRUG: Amoxicillin-clavulanate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is Patients With Pulmonary Disease Benefit a Program With Yogic Exercises?
Status: COMPLETED
Conditions: COPD|Asthma
Interventions: OTHER: Yogic exercises|OTHER: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Mirtoselect®, Virtiva®, and Enovita® on Cognitive Performance and Mood States
Status: COMPLETED
Conditions: Mental Processes|Cognitive Change|Mood Change
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Enovita Grape Seed Extract|DIETARY_SUPPLEMENT: Mirtoselect Bilberry Extract|DIETARY_SUPPLEMENT: Virtiva Plus Ginko Biloba Extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated With Juvenile Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Juvenile Rheumatoid|Uveitis
Interventions: DRUG: Chicken type II collagen
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Psychological Impact in Diabetes: Intervention With Affect School and Basal Body Awareness
Status: TERMINATED
Conditions: Diabetes Mellitus|Depression|Alexithymia|Anxiety
Interventions: BEHAVIORAL: Affect School and Basal body awareness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vandetanib and Temozolomide in Treating Patients With Advanced Solid Tumors That Cannot Be Removed By Surgery
Status: WITHDRAWN
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: temozolomide|DRUG: vandetanib|OTHER: immunoenzyme technique|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Fibrin Sealant (FS) VH S/D-APR for Hemostasis and Wound Healing in Endoscopic Browlift
Status: UNKNOWN
Conditions: Compare Ecchymosis and Edema for Fibrin Sealant and no Fibrin Sealant
Interventions: DRUG: Fibrin Sealant (Artiss)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Levothyroxine Formulation in Hypothyroid Patients With Enteral Feeding
Status: TERMINATED
Conditions: Hypothyroidism
Interventions: DRUG: Levothyroxine Tablet|DRUG: Levothyroxine Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Change Temperature of Skin Surface at the Acupuncture Site, the Neck and the Face When Using Tonifying Acupuncture Manipulations or Dispersing Acupuncture Manipulations at Dazhui in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: PROCEDURE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Perimenopausal Estrogen Replacement Therapy Study
Status: COMPLETED
Conditions: Perimenopause|Menopause|Depression
Interventions: DRUG: Estradiol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Dapagliflozin Therapy in Combination With Insulin in Japanese Subjects With T1DM
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Dapagliflozin 5 mg|DRUG: Dapagliflozin 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-omics Disease Signature Trial in Adult Patients With Moderate to Severe AD
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: LEO 138559|DRUG: Dupixent®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: OSE2101 Alone or in Combination With Pembrolizumab vs BSC in Patient With Platinum-sensitive Recurrent OC
Status: RECRUITING
Conditions: Platinum-sensitive Ovarian Cancer|Relapsed Ovarian Cancer
Interventions: DRUG: OSE2101|DRUG: Pembrolizumab 25 MG/ML [Keytruda]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Pleconaril Nasal Spray on Common Cold Symptoms and Asthma Exacerbations Following Rhinovirus Exposure (Study P04295)
Status: COMPLETED
Conditions: Asthma|Common Cold|Picornavirus Infection|Rhinovirus
Interventions: DRUG: Pleconaril|DRUG: Placebo to Pleconaril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: CNCT19 Cell Injection for Refractory Systemic Lupus Erythematosus
Status: ENROLLING_BY_INVITATION
Conditions: Refractory Systemic Lupus Erythematosus|Lupus Nephritis|Immune Thrombocytopenia
Interventions: DRUG: CNCT19 cell injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: One or Two Week Methotrexate Discontinuation on Efficacy of Influenza Vaccination in Rheumatoid Arthritis.
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Autoimmune Diseases|Influenza|Vaccine Reaction
Interventions: DRUG: MTX-hold
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Durvalumab (MEDI4736) Plus Monalizumab in Non-Muscle-Invasive Bladder Cancer
Status: NOT_YET_RECRUITING
Conditions: Non-muscle Invasive Bladder Cancer|Non-Muscle Invasive Bladder Urothelial Carcinoma
Interventions: DRUG: Durvalumab|DRUG: Monalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sub-dissociative Intranasal Ketamine for Pediatric Sickle Cell Pain Crises
Status: UNKNOWN
Conditions: Sickle Cell Disease
Interventions: DRUG: Ketamine|DRUG: Normal Saline|OTHER: Standard Pain Therapy|OTHER: Pediatric Quality of Life - Sickle Cell Disease Module|OTHER: Faces Pain Scale - Revised
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability and Efficacy of Three Dose Levels of Mitoglitazone in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Mitoglitazone|DRUG: Mitoglitazone|DRUG: Mitoglitazone|DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Nivolumab as a Potential Targeted Treatment in Cancers With Mismatch Repair Deficiency (MATCH-Subprotocol Z1D)
Status: COMPLETED
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Hematopoietic and Lymphoid Cell Neoplasm|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Plasma Cell Myeloma
Interventions: BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT