pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Ph1 Study in Healthy Male Japanese and Caucasian After Single and Multiple Doses of D5884(Omega-3-carboxylic Acids)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: D5884|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fasting Study of Sumatriptan Succinate Tablets 100 mg to Imitrex® Tablets 100 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Sumatriptan Succinate Tablets 100 mg|DRUG: Imitrex® Tablets 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Clinical Trial of Nebulized Hypertonic Saline to Attenuate Post-Traumatic Acute Lung Injury
Status: TERMINATED
Conditions: Acute Lung Injury|Adult Respiratory Distress Syndrome
Interventions: DRUG: Nebulized hypertonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ESP Study: A Study to Assess the Effect of Adding Fuzeon (Enfuvirtide) to an Antiretroviral Regimen in Fuzeon-Naive Patients With Sustained HIV Viral Suppression.
Status: WITHDRAWN
Conditions: HIV Infections
Interventions: DRUG: enfuvirtide [Fuzeon]|DRUG: Antiretroviral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraperitoneal Paclitaxel for Patients With Primary Malignant Peritoneal Mesothelioma
Status: RECRUITING
Conditions: Peritoneal Malignant Mesothelioma
Interventions: DRUG: Intraperitoneal Paclitaxel Solution (Ml)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Nivolumab Versus Placebo in Combination With Neoadjuvant Chemotherapy and Adjuvant Endocrine Therapy in Participants With High-risk, Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor 2-Negative (HER2-) Primary Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: nivolumab|DRUG: paclitaxel (PTX)|OTHER: nivolumab placebo|DRUG: anthracycline|DRUG: cyclophosphamide|DRUG: Endocrine Therapy|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose-Escalation to Rash Study of Tarceva (Erlotinib) Plus Gemcitabine in Patients With Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Erlotinib, escalating dose|DRUG: Erlotinib, standard dose|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Two Spinal Cord Stimulation (SCS) Therapies on Subject Reported Pain (BENEFIT-02)
Status: COMPLETED
Conditions: Chronic Low Back Pain|Chronic Leg Pain
Interventions: DEVICE: Therapy A spinal cord stimulation parameter set using BIO-RNA system and associated components|DEVICE: Therapy B spinal cord stimulation parameter set using BIO-RNA system and associated components
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Treating Sleep Apnea in Patients With Congestive Heart Failure
Status: WITHDRAWN
Conditions: Obstructive Sleep Apnea|Sleep Apnea|Congestive Heart Failure|Heart Failure
Interventions: OTHER: STOP-BANG Scoring Model|OTHER: Polysomnogram Sleep Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pain Neuroscience Education in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Total Knee Replacement
Interventions: BEHAVIORAL: Pain Neuroscience Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Omega -3 Fatty Acids Supplements and Plant Sterol Enriched Food in Dyslipidemic Adults
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: Omega 3 fatty acids and plant sterol enriched drink|DIETARY_SUPPLEMENT: Omega 3 fatty acids and plant sterols
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Study of CD3/CD19 Depleted Haploidentical Stem Cells
Status: UNKNOWN
Conditions: Acute Leukemias|Aplastic Anemia|Childhood Solid Tumor
Interventions: OTHER: Transplantation of CD3/CD19 depleted stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Clinical Trial of a Candidate HPV Vaccine
Status: NOT_YET_RECRUITING
Conditions: Human Papillomavirus Infection
Interventions: BIOLOGICAL: Human papillomavirus (HPV) Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess Adverse Events and How Intravenous (IV) or Subcutaneous (SC) ABBV-382 Moves Through the Body of Adult Participants With Human Immuno-Deficiency Virus (HIV-1)
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV)
Interventions: DRUG: ABBV-382|DRUG: ABBV-382|DRUG: Placebo for ABBV-382
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: IV vs. Oral Acetaminophen as a Component of Multimodal Analgesia After Total Hip Arthroplasty
Status: COMPLETED
Conditions: Pain, Postoperative|Opioid Use
Interventions: DRUG: Acetaminophen|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Nivolumab in Combination With Gemcitabine/Cisplatin or Ipilimumab for Patients With Advanced Unresectable Biliary Tract Cancer
Status: COMPLETED
Conditions: Biliary Tract Neoplasms
Interventions: DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Ipilimumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NeoVax Plus Ipilimumab in Renal Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Cancer
Interventions: DRUG: NeoVax|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pelvis RCT: Impact of Surgery on Pain in Lateral Compression Type Pelvic Fractures
Status: COMPLETED
Conditions: LC Pelvic Fracture
Interventions: PROCEDURE: LC fracture surgical fixation|PROCEDURE: LC fracture non-operative management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Rovalpituzumab Tesirine Administered in Combination With Nivolumab and With or Without Ipilimumab for Adults With Extensive-Stage Small Cell Lung Cancer
Status: TERMINATED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Ipilimumab|DRUG: Nivolumab|DRUG: Rovalpituzumab tesirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Oral Versus Vaginal Misoprostol for Labour Induction at Term
Status: RECRUITING
Conditions: Induction of Labour With Misoprostol
Interventions: DRUG: Misoprostol Oral Tablet|DRUG: vaginal misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Rehab in Chronic Obstructive Pulmonary Disease (COPD): Response to Tyvaso
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Inhaled Treprostinil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Addition of Dronedarone to Standard Rate Control Therapy on Ventricular Rate During Persistent Atrial Fibrillation (AFRODITE)
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Dronedarone|DRUG: Beta blocker or calcium antagonist or digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of an Internet-delivered Treatment Based on Experiential Dynamic Psychotherapy for Social Anxiety Disorder
Status: COMPLETED
Conditions: Social Anxiety Disorder
Interventions: BEHAVIORAL: Experimental: Internet delivered self-help program with therapist support|BEHAVIORAL: Internet delivered self-help program without therapist support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kinetic of Compounds of a Melatonin-based Formulation in Healthy Subjects
Status: COMPLETED
Conditions: Melatonin Bioavailability
Interventions: DIETARY_SUPPLEMENT: dietary supplement, 1 tablet containing delayed release melatonin, zinc and lemon balm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Two Resistance Training Protocols to Reduce the Risk of Falls in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease|Accidental Falls
Interventions: OTHER: Resistance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Healthy Opioid Prescription Engagement
Status: RECRUITING
Conditions: Opioid Misuse|Opioid-Related Disorders|Pharmacist-Patient Relations
Interventions: BEHAVIORAL: Patient Navigation|OTHER: Standard Medication Counseling (SMC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Expanding the Potential of Couples HIV Testing: Adjunct Modules to Reduce Drug Use Among Vulnerable Male Couples
Status: RECRUITING
Conditions: Substance Use|HIV Infections
Interventions: BEHAVIORAL: Communication skills training video|BEHAVIORAL: Drug use module
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: CA-IX, p16, Proliferative Markers, and HPV in Diagnosing Cervical Lesions in Patients With Abnormal Cervical Cells
Status: ACTIVE_NOT_RECRUITING
Conditions: Atypical Endometrial Hyperplasia|Human Papillomavirus Infection|Stage 0 Cervical Cancer AJCC v7
Interventions: OTHER: Cytology Specimen Collection Procedure|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Nefopam on Remifentanil Induced Postoperative Hyperalgesia
Status: COMPLETED
Conditions: Patients Undergoing Laparoscopic Gastrectomy
Interventions: DRUG: Nefopam|DRUG: low dose remifentanil|DRUG: high dose remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination of Leukocyte Cell Surface Biomarkers Measured by Cytometry, to Differentiate Bacterial From Viral Infections in Emergency Department: a Multicentric Cohort for the Validation of Diagnostic Performances
Status: RECRUITING
Conditions: Bacterial and Viral Infections
Interventions: DIAGNOSTIC_TEST: 2 additional whole blood samples of 6mL each will be taken
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Photobiomodulation Therapy in Persons With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: OTHER: Photobiomodulation Therapy|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Evaluating the Safety and Efficacy of Brexucabtagene Autoleucel (KTE-X19) in Adult Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (ZUMA-3)
Status: COMPLETED
Conditions: Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: brexucabtagene autoleucel|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Saracatinib in Treating Patients With Prostate Cancer
Status: TERMINATED
Conditions: Hormone-resistant Prostate Cancer|Recurrent Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: saracatinib|OTHER: hydrocortisone/placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Once Daily PMR Compared to Twice Daily Cilostazol IR Tablets in Healthy Volunteers
Status: COMPLETED
Conditions: Intermittent Claudication
Interventions: DRUG: Cilostazol 100 mg|DRUG: PMR 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EEG Biofeedback to Improve Memory in Adults With Dementia
Status: COMPLETED
Conditions: Dementia
Interventions: BEHAVIORAL: QEEG-based Neurofeedback Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brentuximab Vedotin With Pembrolizumab in Metastatic Solid Tumors
Status: RECRUITING
Conditions: Melanoma|Non-small Cell Lung Cancer|Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: brentuximab vedotin|DRUG: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Video-assisted Thoracoscopic Thymectomy Versus Subxiphoid Procedure
Status: RECRUITING
Conditions: Thymectomy
Interventions: PROCEDURE: Subxiphoid surgery procedure|PROCEDURE: VATS surgery procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Mixture of Probiotics on the Antigen Specific Antibody Response in a Influenza Vaccination Model of Healthy Adults
Status: COMPLETED
Conditions: Enhancement of Protective Antibody Response After Probiotic Consumption
Interventions: DIETARY_SUPPLEMENT: Mixture of probiotics|DIETARY_SUPPLEMENT: Mixture of probitiocs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: LOng COvid COmorbidities: Endocrine,Metabolic,Neuropsychiatric,Muscle,Cardiovascular,Pulmonary,Dermatologic Dysfunctions
Status: UNKNOWN
Conditions: Long Covid-19
Interventions: DIAGNOSTIC_TEST: Assessments of endocrinological phenotypes of LO-COCO patients|DIAGNOSTIC_TEST: Assessment of muscular phenotypes of LO-COCO patients|DIAGNOSTIC_TEST: Assessment of neuropsychiatric phenotypes of LO-COCO patients|PROCEDURE: Muscle biopsy|DIAGNOSTIC_TEST: Assessment of pulmonary phenotypes of LO-COCO patients|DIAGNOSTIC_TEST: Assessment of cardiological phenotypes of LO-COCO patients|DIAGNOSTIC_TEST: Assessment of vascular phenotypes of LO-COCO patients|DIAGNOSTIC_TEST: Assessment of dermatological phenotypes of LO-COCO patients|PROCEDURE: Tissue biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Studies of Brain and Body Interaction
Status: UNKNOWN
Conditions: Autistic Disorders Spectrum|Adhd|Asperger Syndrome|Alzheimer Disease|Parkinson|Tremor Essential|Dementia, Alzheimer Type|Lewy Body Dementia With Behavioral Disturbance (Disorder)|Dementia With Lewy Bodies|Dementia Frontal
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Heart and Estrogen-Progestin Replacement Study (HERS)
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DRUG: Premarin .625 mg daily plus medroxyprogesterone 2.5 mg daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Donor Stem Cell Transplant After Busulfan, Fludarabine, and Antithymocyte Globulin in Treating Patients With Hematological Cancer
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: BIOLOGICAL: anti-thymocyte globulin|DRUG: busulfan|DRUG: fludarabine phosphate|DRUG: leucovorin calcium|DRUG: methotrexate|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: nonmyeloablative allogeneic hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Gingival Recession-type Defects Using Different Restorative Materials
Status: COMPLETED
Conditions: Gingival Recession|Tooth Abrasion
Interventions: PROCEDURE: connective tissue graft+composite resin|PROCEDURE: connective tissue graft+ glass ionomer|PROCEDURE: connective tissue graft+giomer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Structural and Functional Brain Reorganization in Neuropathic Pain: Basal State of Local Cerebral Blood Flow and Functional Connectivity
Status: TERMINATED
Conditions: Neuropathic Pain
Interventions: RADIATION: MRI scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Adjunctive 5% Lidocaine Patches for Acute Non-radicular Low Back Pain in Emergency Department Patients
Status: WITHDRAWN
Conditions: Low Back Pain
Interventions: DRUG: lidocaine 5% patch|DRUG: standard therapy|DRUG: Non-medicated patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An 18-month Low-interventional Study to Assess Joint Health in Haemophilia A and B Patients on Prophylaxis With Efmoroctocog Alfa or Eftrenonacog Alfa
Status: TERMINATED
Conditions: Hemophilia A|Hemophilia B
Interventions: PROCEDURE: Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US)|OTHER: Haemophilia Joint Health Score (HJHS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bortezomib Based Consolidation in Multiple Myeloma Patients Completing Stem Cell Transplant
Status: COMPLETED
Conditions: Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma
Interventions: DRUG: bortezomib|DRUG: cyclophosphamide|DRUG: lenalidomide|OTHER: laboratory biomarker analysis|DRUG: dexamethasone|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of FCI in the Detection of Proctosigmoiditis Caused by IBD
Status: WITHDRAWN
Conditions: Inflammatory Bowel Diseases|Proctosigmoiditis
Interventions: DEVICE: Field-cycling imaging (FCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: NAC vs Placebo on Opioid Use for Hysterectomy
Status: RECRUITING
Conditions: Hysterectomy
Interventions: DRUG: IV N-acetylcysteine|DRUG: IV Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dispensing Clinical Trial of Comfilcon A Extended Range Multifocal Lenses
Status: COMPLETED
Conditions: Presbyopia
Interventions: DEVICE: comfilcon A Extended Range test lens|DEVICE: comfilcon A control lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: High Dose Therapy and Autologous Stem Cell Transplantation Followed by Infusion of Chimeric Antigen Receptor (CAR) Modified T-Cells Directed Against CD19+ B-Cells for Relapsed and Refractory Aggressive B Cell Non-Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Carmustine|DRUG: Etoposide|DRUG: Cytarabine|DRUG: Melphalan|BIOLOGICAL: Pegfilgrastim|BIOLOGICAL: 19-28z T CELLS|PROCEDURE: Autologous Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: European Trial Into Mpox Infection
Status: RECRUITING
Conditions: Monkeypox
Interventions: DRUG: Tecovirimat Oral Capsule|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III, Randomized, Multi-center Study to Determine the Efficacy of the Intercalating Combination Treatment of Chemotherapy and Gefitinib or Chemotherapy as Adjuvant Treatment in NSCLC With Common EGFR Mutations.
Status: UNKNOWN
Conditions: Completely Resected NSCLC With Common EGFR Mutations
Interventions: DRUG: gefitinib, pemetrexed,cisplatin|DRUG: Vinorelbine, cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melodic-Intonation-Therapy and Speech-Repetition-Therapy for Patients With Non-fluent Aphasia
Status: COMPLETED
Conditions: Aphasia|Stroke|Cerebrovascular Accident|Apoplexy|Cerebral Infarction
Interventions: BEHAVIORAL: Melodic Intonation Therapy|BEHAVIORAL: Speech-Repetition-Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GTB-3550 Tri-Specific Killer Engager (TriKE®) for High Risk Hematological Malignancies
Status: TERMINATED
Conditions: High-risk Myelodysplastic Syndromes|Acute Myelogenous Leukemia|Systemic Mastocytosis|Mast Cell Leukemia
Interventions: DRUG: GTB-3550 TriKE® Phase I|DRUG: GTB-3550 TriKE® Phase II
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Eight-week Study Evaluating the Efficacy and Tolerability of Two Doses of SSR149415 in Outpatients With Generalized Anxiety Disorder
Status: COMPLETED
Conditions: Anxiety Disorders
Interventions: DRUG: SSR149415|DRUG: Placebo|DRUG: Paroxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Pembrolizumab in Combination With Gemcitabine Therapy in Cis-eligible/Ineligible UC Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Urothelial Carcinoma|Bladder Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Gemcitabine|DRUG: Cisplatin|PROCEDURE: Consolidative Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Maintenance of Effect of Ziprasidone Plus a Mood Stabilizer in Bipolar I Disorder (Manic or Mixed)
Status: COMPLETED
Conditions: Bipolar Mania|Bipolar Disorder
Interventions: DRUG: Placebo|DRUG: Ziprasidone Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Analgesic Efficacy of ASP7962 in Patients With Pain Due to Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis of the Knee|Chronic Lower Back Pain
Interventions: DRUG: ASP7962|DRUG: Naproxen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PEGASUS - Improving Treatment for Patients With Emotionally Unstable Personality Disorder
Status: NOT_YET_RECRUITING
Conditions: Borderline Personality Disorder|Relatives
Interventions: OTHER: The experimental intervention PEGASUS|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Phase III Trial of Chemotherapy Alone Versus Chemotherapy Followed by Gefitinib in Stage IIIB/IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: platinum-based chemotherapy alone (up to six cycles)|DRUG: platinum-based chemotherapy followed by maintenance therapy with gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of TACE, Lenvatinib and Camrelizumab in the Treatment of BCLC Stage B/C Hepatocellular Carcinoma: a Single-arm, Single-center, Open-label Study
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: COMBINATION_PRODUCT: TACE+Lenvatininb+Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of MORAb-003 in Subjects With Advanced Ovarian Cancer
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer
Interventions: DRUG: MORAb-003
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Oral N-Acetyl Cysteine for the Treatment of Chronic Sinonasal Symptoms
Status: UNKNOWN
Conditions: Chronic Sinonasal Symptoms
Interventions: DRUG: N-Acetyl Cysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stochastic Resonance Applied to Amblyopia Training and the Plasticity of Brain
Status: COMPLETED
Conditions: Amblyopia|Amblyopia, Anisometropic
Interventions: DEVICE: Portable tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of AERAS-402 in Healthy Infants
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: AERAS-402 1.5 x 10^10 vp|BIOLOGICAL: AERAS-402 3.0 x 10^10 vp|BIOLOGICAL: AERAS-402 1.0 x 10^11 vp|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bleeding Pattern Study
Status: COMPLETED
Conditions: Oral Contraceptive
Interventions: DRUG: Valette (Dienogest/EE30, BAY86-5038)|DRUG: Valette (Dienogest/EE30, BAY86-5038)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessing an Oral EGFR Inhibitor,YK-209A in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR
Status: RECRUITING
Conditions: Treatment|Treatment Side Effects
Interventions: DRUG: YK-029A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Discovering Novel Cancer Treatment Options Using a Comprehensive NGS-based Molecular Testing Panel in the Community Setting ("DINOSAur")
Status: RECRUITING
Conditions: Stage III Solid Tumors|Stage IV Solid Tumors
Interventions: DIAGNOSTIC_TEST: Comprehensive molecular panel test|OTHER: EORTC QLQ-30
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Efficacy and Safety of MABT5102A in Patients With Mild to Moderate Alzheimer's Disease (ABBY)
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: MABT5102A|DRUG: MABT5102A|DRUG: placebo|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Peri-procedural Complications of Intracardiac Echocardiography and Transesophageal Echocardiography in Patients With Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DEVICE: ICE|DEVICE: TEE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Oversight of the Individually Tailored Treatment Approach: A Novel Pilot Study
Status: TERMINATED
Conditions: Cancer
Interventions: DRUG: Trametinib|DRUG: Cobimetinib|DRUG: Binimetinib|DRUG: Alpelisib|DRUG: Vemurafenib|DRUG: Dabrafenib|DRUG: Encorafenib|DRUG: Palbociclib|DRUG: Olaparib|DRUG: Ribociclib|DRUG: Abemaciclib|DRUG: Talazoparib|DRUG: Nivolumab|DRUG: Atezolizumab|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Allergen Component Resolved Diagnosis to Decide Immunotherapy
Status: RECRUITING
Conditions: Asthma|Rhinitis, Allergic
Interventions: DIAGNOSTIC_TEST: Component resolved diagnosis|DIAGNOSTIC_TEST: Standard diagnosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Clinical Study to Evaluate Efficacy and Safety of Serplulimab（HLX10） Combined With Bevacizumab（HLX04) and Chemotherapy (XELOX) in Patients With Metastatic Colorectal Cancer (mCRC)
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: HLX10|DRUG: HLX04、
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Restoration of Hypoglycemia Awareness With Home-based High Intensity Interval Training
Status: RECRUITING
Conditions: Type 1 Diabetes|Hypoglycemia Unawareness
Interventions: DEVICE: Continuous glucose monitoring device|OTHER: Gold method|OTHER: Clarke questionnaire|OTHER: Edinburgh Hypoglycemia Symptom Scale|OTHER: BAPAD questionnaire|OTHER: Hypoglycemia Fear Survey II|OTHER: Physical activity questionnaire|OTHER: Well-being|OTHER: Treatment satisfaction|OTHER: Hypoglycemia diary|DEVICE: Piezo RxD|DEVICE: Heart rate monitor|OTHER: Exercise diary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgery or Chemotherapy in Recurrent Ovarian Cancer (SOC 1 Trial)?
Status: UNKNOWN
Conditions: Ovarian Epithelial Cancer Recurrent|Fallopian Tube Carcinoma|Primary Peritoneal Carcinoma
Interventions: PROCEDURE: Secondary Cytoreductive Surgery|DRUG: Salvage Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sonar Guided vs Surgeon Delivered Parasternal Block
Status: UNKNOWN
Conditions: Parasternal Intercostal Nerve Block
Interventions: PROCEDURE: US-guided Parasternal block|PROCEDURE: Surgeon-delivered parasternal block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Which is the Most Reliable Radiologic Examination for the Diagnosis of Rotator Cuff Tendon Tear?
Status: COMPLETED
Conditions: Shoulder|Rotator Cuff Disease
Interventions: OTHER: Imaging Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CC486-CHOP in Patients With Previously Untreated Peripheral T-cell Lymphoma
Status: COMPLETED
Conditions: Previously Untreated Peripheral T-cell Lymphoma
Interventions: DRUG: CC-486 Administration|DRUG: CHOP Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Angiotensin-(1,7) Treatment in COVID-19: the ATCO Trial
Status: UNKNOWN
Conditions: Coronavirus|Respiratory Failure|Coronavirus Sars-Associated as Cause of Disease Classified Elsewhere|SARS-CoV-2
Interventions: DRUG: Angiotensin 1-7|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Media Literacy for High School Tobacco Prevention
Status: ACTIVE_NOT_RECRUITING
Conditions: Adolescent Behavior|Tobacco Use|E-Cig Use
Interventions: BEHAVIORAL: AD IT UP media literacy intervention|BEHAVIORAL: Usual health education curriculum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Non-invasive Stimulation Through Nesa and Therapeutic Exercise on Sleep Disturbances on Alzheimer's Disease Patients.
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DEVICE: non-invasive neuromodulation through the Nesa device|PROCEDURE: therapeutic exercise|BEHAVIORAL: sleep hygiene measures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reduced Intensity (RIC) Conditioning And Transplantation of HLA-Haplo-HCT
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematologic Malignancies
Interventions: BIOLOGICAL: Haplo HCT <55 years old|BIOLOGICAL: Haplo HCT ≥55 years old|DRUG: GVHD Prophylaxis|BIOLOGICAL: Haplo HCT ≥55 and < 65 years old|BIOLOGICAL: Haplo HCT ≥65 and ≤75 years old
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Pilates in the Recovery of Post-prostatectomy Urinary Incontinence
Status: COMPLETED
Conditions: Prostate Cancer|Urinary Incontinence
Interventions: OTHER: PILATES|OTHER: PFMT and AES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Presynaptic Imaging in Major Depressive Episodes After COVID-19
Status: RECRUITING
Conditions: Long COVID|Major Depressive Disorder|Major Depressive Episode
Interventions: OTHER: [11C]DTBZ PET scan|OTHER: [18F]SDM8 PET scan|OTHER: MRI scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multi-parametric Magnetic Resonance Imaging for the Precise Diagnosis and Quantitative Study of Liver Steatosis, Inflammation, and Fibrosis in Chronic Liver Disease.
Status: RECRUITING
Conditions: Liver Stiffness
Interventions: DEVICE: 3D-MRE,MRI-PDFF
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Esketamine-propofol Versus Propofol for Flexible Bronchoscopy
Status: COMPLETED
Conditions: Postoperative Recovery
Interventions: DRUG: 0.1 mg/kg esketamine|DRUG: 0.2 mg/kg esketamine|DRUG: 0.9% saline|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PURETHAL Grasses Rush Study
Status: COMPLETED
Conditions: Allergic Rhinitis|Allergic Rhinoconjunctivitis
Interventions: DRUG: PURETHAL Grasses, 20.000 AUM/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parent and Family Obesity Intervention in Reducing Obesity Risk in Racial Ethnic Minority Families
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity-Related Malignant Neoplasm
Interventions: BEHAVIORAL: Behavioral Intervention|OTHER: Counseling|PROCEDURE: Discussion|OTHER: Educational Intervention|OTHER: Informational Intervention|OTHER: Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of an Inpatient Program for Long-term Weight Maintenance in Children and Adolescents With Morbid Obesity
Status: UNKNOWN
Conditions: Morbid Obesity
Interventions: BEHAVIORAL: inpatient hospitalization and follow up|BEHAVIORAL: inpatient treatment and follow up|PROCEDURE: bariatric surgery|BEHAVIORAL: inpatient treatment with follow up
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Cartilage and Muscle Thickness on Knee Pain in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Knee Pain Chronic|Muscle Loss|Cartilage Degeneration
Interventions: DIAGNOSTIC_TEST: Ultrasonographic Measurements
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reducing the Weight of Overweight Schizophrenia Patients
Status: COMPLETED
Conditions: Schizophrenia|Obesity
Interventions: BEHAVIORAL: Behavioral training|BEHAVIORAL: Social skills training|BEHAVIORAL: Behavioral training booster sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Forearm Casting Versus Below-elbow Splinting for Acute Immobilization of Distal Radius Fractures
Status: TERMINATED
Conditions: Distal Radius Fracture
Interventions: DEVICE: Sugar-tong splint|DEVICE: Short forearm cast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AcoArt VI / Vertebral Artery Ostium Stenosis in China
Status: COMPLETED
Conditions: Ischemic Stroke|Transient Ischemic Attack
Interventions: PROCEDURE: drug-coated balloon catheter（Orchid, Acotec）|PROCEDURE: Intracranial artery stent system（APOLLO）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of SOBI002 in Healthy Volunteers Following Single and Repeated Administration
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: SOBI002|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Azithromycin Plus Pyrimethamine in the Treatment of a Brain Infection in Patients With AIDS
Status: COMPLETED
Conditions: Toxoplasmosis, Cerebral|HIV Infections
Interventions: DRUG: Azithromycin|DRUG: Pyrimethamine|DRUG: Leucovorin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Acute Exposure to High Altitude on Pulmonary Artery Pressure and Right Heart Function (Echo)
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: OTHER: Assessment at Low Altitude (470m above sea level)|OTHER: Exposure to High Altitude (2500m above sea level)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating the Efficacy and Safety of 0.05% Ingenol Mebutate (Picato® 500) in the Treatment of Basal Cell Carcinoma
Status: COMPLETED
Conditions: Carcinoma
Interventions: DRUG: Picato 0.05% Topical Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Explore the Safety and Efficacy of Hypidone Hydrochloride Tablets in Treatment of Patients With MDD
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Hypidone Hydrochloride tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microembolic Signals During CPVI (Circumferntial Pulmonary Vein Isolation) Assessed by TCD (Trans-cranial Doppler)
Status: COMPLETED
Conditions: Atrial Fibrillation.
Interventions: DEVICE: TCD monitoring of microembolic signal during procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Use of Cell Salvage Post-operatively in Infants to Decrease Use of Allogeneic Blood Product Transfusions
Status: COMPLETED
Conditions: Transfusion
Interventions: OTHER: Cell Saver RBCs|OTHER: Conventional volume infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pramlintide and Fiasp Closed-Loop With a Simple Meal Announcement
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: COMBINATION_PRODUCT: Fiasp+Pramlintide Closed-Loop System|DEVICE: Fiasp Closed-Loop System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate in Healthy Volunteers (Part 1) and in Patients With Type 2 Diabetes Mellitus (Part 2) the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of RO6799477
Status: COMPLETED
Conditions: Healthy Volunteer, Type 2 Diabetes
Interventions: DRUG: Placebo|DRUG: RO6799477
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nasogastric Tube Insertion Using Cook Airway Exchange Catheter in Anesthetized Patients
Status: UNKNOWN
Conditions: Elective Surgery of Gastrointestinal Tract|100 Adults Aged Between 20 and 70 Years Old|ASA Physical Status of I or II
Interventions: DEVICE: TUBE EXCHANGER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palliative Care for Persons With Late-stage Alzheimer's and Related Dementias and Their Caregivers
Status: ENROLLING_BY_INVITATION
Conditions: Dementia|Dementia, Vascular|Dementia With Lewy Bodies|Dementia Frontal|Dementia, Mixed|Dementia Alzheimers|Alzheimer Disease|Dementia Severe
Interventions: BEHAVIORAL: ADRD-PC Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Plasma Neutrophil Gelatinase-associated Lipocalin (NGAL) as Early Biomarker for Renal Dysfunction and Good Neurologic Outcome in Out of Hospital Cardiac Arrest Patients
Status: UNKNOWN
Conditions: Post Cardiac Arrest Patient Who Was Treated by Hypothermia Protocol
Interventions: BIOLOGICAL: Serum NGAL level
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety and Efficacy of Amphinex Induced PCI of Bleomycin for Recurrent Head and Neck Cancer.
Status: TERMINATED
Conditions: Recurrent Head and Neck Cancer|Carcinoma, Squamous Cell of Head and Neck
Interventions: DRUG: Amphinex induced PCI of bleomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Two Different Video Showings on Pain and Anxiety in Children Undergoing Adenotonsillectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain After Adenotonsillectomy
Interventions: OTHER: The Effect of Two Different Video Interventions on Pain and Anxiety in Children with Adenotonsillectomy: A Randomized Controlled Study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Perioperative Respiratory Adverse events_sugammadex
Status: UNKNOWN
Conditions: Respiratory Complication
Interventions: DRUG: Sugammadex injection|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Manchester Intermittent Diet in Gestational Diabetes Acceptability Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Gestational Diabetes|Gestational Diabetes Mellitus in Pregnancy|Intermittent Fasting|Pregnancy Related|Diabetes|Diabetes in Pregnancy
Interventions: OTHER: Best NHS Care|OTHER: Intermittent Low Energy Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computerized Decision Support for Prevention of VTE in Hospitalized Medical Patients Across the Continuum of Care (DC-eALERT)
Status: RECRUITING
Conditions: Venous Thromboembolism
Interventions: BEHAVIORAL: Electronic alert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Appetite Satisfaction and Short-term Satiety of Different Plant Compositions in the Adolescent Age Group
Status: COMPLETED
Conditions: Satiety|Appetite
Interventions: DIETARY_SUPPLEMENT: Fiber product|DIETARY_SUPPLEMENT: Control product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Acute-phase Response & Periodontal Treatment in Diabetes Affected Patients
Status: COMPLETED
Conditions: Periodontitis|Diabetes
Interventions: PROCEDURE: FM-SRP|PROCEDURE: Q-SRP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TIcaGrEloR and ABSORB Bioresorbable Vascular Scaffold Implantation for Recovery of Vascular Function After Successful Chronic Total Occlusion Recanalization
Status: COMPLETED
Conditions: Patients Who Are Scheduled to Undergo a PCI (Percutaneous Coronary Intervention) for CTO (Chronic Total Occlusion)
Interventions: DRUG: Clopidogrel|DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT