pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Meals for Moms: Medically-Tailored Meals for Women Who Had Gestational Diabetes
Status: COMPLETED
Conditions: Diabetes, Gestational|Gestational Weight Gain|Postpartum Weight Retention
Interventions: BEHAVIORAL: Medically Tailored Meals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Colchicine in Acutely Decompensated HFREF
Status: RECRUITING
Conditions: Heart Failure|Decompensated Heart Failure|Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: Colchicine 0.6 mg|DRUG: Control/Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Precision High-Intensity Training Through Epigenetics (PHITE)
Status: COMPLETED
Conditions: Healthy
Interventions: BEHAVIORAL: Moderate Intensity|BEHAVIORAL: High Intensity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
Status: ACTIVE_NOT_RECRUITING
Conditions: Age-related Cognitive Decline|Mild Cognitive Impairment|Dementia
Interventions: BEHAVIORAL: Cognitive Training|BEHAVIORAL: Computerized Cognitive Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Digestive Tolerance of Maltitol and FOS
Status: COMPLETED
Conditions: Digestive Tolerance in Healthy Adults
Interventions: OTHER: maltitol 85% / FOS15%|OTHER: maltitol alone|OTHER: maltitol 68% / FOS 32%|OTHER: maltitol 50% / FOS 50%|OTHER: FOS alone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Role of Concurrent Chemotherapy for Lower Risk Locally Advanced Nasopharyngeal Carcinoma(NPC) in the Era of IMRT
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: RADIATION: SIB-IMRT|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Different Methods of Respiratory Muscle Training on Athletic Performance and Pulmonary Function in Short-track Speedskaters
Status: ENROLLING_BY_INVITATION
Conditions: Respiratory Muscle Training
Interventions: BEHAVIORAL: Respiratory Muscle Training - VIH|BEHAVIORAL: Respiratory Muscle Training - ITPL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Treatment of Macular Edema Caused by Leber's Miliary Aneurysms Using Intravitreal Aflibercept and Peripheral Laser Photocoagulation
Status: UNKNOWN
Conditions: Macular Edema Caused by Leber's Miliary Aneurysms
Interventions: OTHER: Panretinal photocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of exeRcise And Diet on Quality of Life in Patients With Incurable Cancer of Esophagus and Stomach (RADICES)
Status: RECRUITING
Conditions: GastroEsophageal Cancer|Incurable Disease
Interventions: OTHER: Exercise intervention|OTHER: Nutrition intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Propofol Requirement Between Patients With Pituitary Somatotroph Tumor and With Nonfunctioning Pituitary Tumor in Transsphenoidal Pituitary Surgery Under Total Intravenous Anesthesia
Status: COMPLETED
Conditions: Pituitary Tumor
Interventions: PROCEDURE: Not applicable (measuring subject's effect site concentration of propofol during the induction of general anesthesia)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD)
Status: TERMINATED
Conditions: Pulmonary Hypertension|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Inhaled treprostinil solution|DRUG: Placebo solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tunnel Access for Horizontal Alveolar Ridge Augmentation
Status: NOT_YET_RECRUITING
Conditions: Bone Atrophy, Alveolar|Bone Loss|Bone Resorption|Alveolar Bone Loss|Alveolar Bone Resorption
Interventions: PROCEDURE: Horizontal Ridge augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Efficacy and Safety of FFX Versus Combination of CPI-613 With mFFX in Patients With Metastatic Adenocarcinoma of the Pancreas
Status: COMPLETED
Conditions: Pancreatic Cancer Metastatic
Interventions: DRUG: CPI 613, mFolfirinox|DRUG: Folfirinox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnosis of Periprosthetic Joint Infection and the Common Pathogens, Durg-resistance in Periprosthetic Joint Infection
Status: UNKNOWN
Conditions: Arthropathy of Hip|Arthropathy of Knee
Interventions: OTHER: Periprosthetic Joint Infection|OTHER: Non-Periprosthetic Joint Infection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Etanercept in Hidradenitis Suppurativa
Status: COMPLETED
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: Etanercept sc 50mg per week for 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Dexamethasone and Triamcinolone for Ultrasound-guided Occipital C2 Nerve Blocks
Status: WITHDRAWN
Conditions: Headache
Interventions: DRUG: Triamcinolone|DRUG: Dexamethasone|DRUG: Normal Saline|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Paclitaxel-Eluting Coroflex Please Stent Versus Paclitaxel-Eluting Stent
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: CoroflexTM Please|DEVICE: Paclitaxel-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Phase II Trial Using ctDNA to Initiate Post-operation Boost Therapy After NAC in TNBC
Status: RECRUITING
Conditions: Triple-negative Breast Cancer
Interventions: DRUG: Tislelizumab|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of GX-I7 in Combination With Pembrolizumab in Refractory or Relapsed (R/R) TNBC Subjects(GX-I7-CA-006/KEYNOTE-899)
Status: COMPLETED
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: GX-I7|DRUG: Pembrolizumab(KEYTRUDA®)|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repeated Open Application Test (ROAT) Study With Hydroperoxides of Linalool
Status: NOT_YET_RECRUITING
Conditions: Allergic Contact Dermatitis
Interventions: DIAGNOSTIC_TEST: ROAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: DEXTENZA for the Treatment of Postoperative Pain and Inflammation Following Vitreo-retinal Surgery
Status: COMPLETED
Conditions: Vitreo-Retinal Surgery
Interventions: DRUG: Dextenza 0.4Mg Ophthalmic Insert|DRUG: Topical Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Iron Protein Succinylate Oral Solution in Treating Chronic Heart Failure and Iron Deficiency
Status: UNKNOWN
Conditions: Chronic Heart Failure|Iron-deficiency
Interventions: DRUG: Iron protein succinylate oral solution|OTHER: standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Deflazacort (Emflaza®) in Participants With Limb-Girdle Muscular Dystrophy 2I (LGMD2I)
Status: TERMINATED
Conditions: Limb-Girdle Muscular Dystrophy
Interventions: DRUG: Deflazacort
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study of Single Oral Doses of Six Different Vitamin C Product Forms
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy|Pharmacokinetic
Interventions: DIETARY_SUPPLEMENT: TP1|DIETARY_SUPPLEMENT: TP2|DIETARY_SUPPLEMENT: TP3|DIETARY_SUPPLEMENT: TP4|DIETARY_SUPPLEMENT: CP|DIETARY_SUPPLEMENT: RP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Exploring the Use of Challenge Agents in Healthy Volunteers - Intervention Specific Appendix
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Indomethacin|DIAGNOSTIC_TEST: Lactulose-mannitol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Chemotherapy and Peripheral Stem Cell Transplantation Followed by Trastuzumab in Treating Women With Metastatic Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: carboplatin|DRUG: carmustine|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: thiotepa|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Etoricoxib/Cyanocobalamin Versus Etoricoxib for Acute Low Back Pain
Status: RECRUITING
Conditions: Acute Low-back Pain
Interventions: DRUG: Etoricoxib + Cyanocobalamin fixed dose|DRUG: Etoricoxib fixed dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guérin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Urinary Bladder Neoplasms
Interventions: DRUG: TAR-200|BIOLOGICAL: Cetrelimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2a Study to Evaluate EDP-938 in the Virus Challenge Model
Status: COMPLETED
Conditions: RSV Infection
Interventions: DRUG: EDP-938 Dose 1|DRUG: EDP-938 Dose 2|DRUG: Placebo|DRUG: EDP-938 Dose 3|DRUG: EDP-938 Dose 4|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Tailored, Health Communication Intervention for HPV Vaccine Hesitant Families
Status: UNKNOWN
Conditions: Human Papilloma Virus|HPV-Related Carcinoma|Vaccine Refusal|Parents|Program, Communication
Interventions: BEHAVIORAL: Mobile Phone-Based Web-Page: HPV vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of the Farnesyl-transferase Inhibitor (Tipifarnib) in Mantle Cell Lymphoma
Status: TERMINATED
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: ZARNESTRA (Tipifarnib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose-ranging Safety and Efficacy Study of Ecallantide to Reduce Surgical Blood Loss Volume
Status: COMPLETED
Conditions: Bloodloss|Surgical Procedures, Operative
Interventions: DRUG: ecallantide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ferrous Sulfate Versus Iron Amino Acid Chelate
Status: COMPLETED
Conditions: Iron Deficiency
Interventions: OTHER: Ferrous sulfate as dietary supplementation|OTHER: Iron amino acid chelated as dietary supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetics and Safety of Tigecycline in the Treatment of Clostridium Difficile Associated Diarrhea (CDAD)
Status: COMPLETED
Conditions: Diarrhea|Clostridium Difficile
Interventions: DRUG: Tigecycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Assess the Absorption, Metabolism, Excretion, and Mass Balance of [14C]-Darigabat After a Single Oral Dose in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: [14C]-darigabat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Decompression With and Without ELDOA in Lumber Disc Protrusion Patients
Status: COMPLETED
Conditions: Lumbar Disc Herniation
Interventions: OTHER: Elongation Longitudinaux Avec Decoaption Osteo Articulaire|OTHER: Decompression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KN035 in Combination With Trastuzumab and Docetaxel in HER2-positive Breast Cancer
Status: UNKNOWN
Conditions: HER2-positive Breast Cancer
Interventions: BIOLOGICAL: KN035|BIOLOGICAL: Trastuzumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Desvenlafaxine Sustained-Release (DVS-SR) in Adult Outpatients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: DVS-SR 50 mg|DRUG: DVS-SR 100 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Belimumab in Remission of VASculitis
Status: COMPLETED
Conditions: Vasculitis
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: Belimumab 10 mg/kg|DRUG: Azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Structure, Function, and Clinical Manifestations in MINOCA
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Myocardial Infarction
Interventions: OTHER: Integrative characterization of MINOCA patients|OTHER: Characterization of MI patients with coronary obstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Safety and Efficacy of LT3001 Drug Product in Subjects AIS Undergoing EVT
Status: UNKNOWN
Conditions: Acute Ischemic Stroke
Interventions: DRUG: LT3001 Drug Product|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Efficacy and Safety of CKD-351
Status: UNKNOWN
Conditions: Primary Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: CKD-351|DRUG: Latanoprost+Dorzolmamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medications Development for the Treatment of Cannabis Related Disorders
Status: COMPLETED
Conditions: Nicotine Withdrawal|Marijuana Dependence|Cannabis Dependence|Nicotine Dependence|Cannabis Abuse
Interventions: DRUG: Placebo Aprepitant|DRUG: Active Aprepitant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Does Early Administration of Ultrasound Guided Regional Anesthesia for Long Bone Fractures Effect Long Term Patient Opioid Usage
Status: UNKNOWN
Conditions: Bone Fracture|Opioid Use|Opioid Dependence
Interventions: OTHER: SOC Pain Management|PROCEDURE: Early US Guided Nerve Block Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study Evaluating the Effects of Lipid Lowering Treatment on Steroid Synthesis
Status: UNKNOWN
Conditions: Coronary Heart Disease|Diabetes Mellitus|Non-Coronary Atherosclerotic Disease|Hypercholesterolemia
Interventions: DRUG: Atorvastatin, Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Transversus Abdominis Plane Versus Caudal Block for Pediatrics
Status: COMPLETED
Conditions: Lower Abdominal Surgery
Interventions: OTHER: Transversus abdominis plane block|OTHER: Caudal block|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Two Fixed Dose Combinations of Aclidinium Bromide With Formoterol Fumarate
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Aclidinium 200 μg / formoterol 12 μg|DRUG: Placebo|DRUG: Formoterol 12 μg|DRUG: Aclidinium 200 μg|DRUG: Aclidinium 200 μg / Formoterol 6 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Ascending and Descending Direct Current on the Handgrip Strength
Status: COMPLETED
Conditions: Muscle Strength
Interventions: PROCEDURE: Upward Direct Current (Ascending Effect)|PROCEDURE: Downward Direct Current (Descending Effect)|PROCEDURE: Sham Direct Current
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Minocycline Study in Pancreatic Cancer Patients
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Minocycline|OTHER: Placebo|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study on the Effect of Dexmedetomidine on Inflammatory Responses in Patients Undergoing Lumbar Spinal Fusion
Status: TERMINATED
Conditions: Spinal Stenosis|Inflammation
Interventions: DRUG: Dexmedetomidine group|DRUG: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Laparoscopic Roux-en-Y Gastric Bypass Surgery on Non-severe Obesity With Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Diabetes Mellitus, Non-Insulin-Dependent
Interventions: PROCEDURE: gastric bypass surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Self-Injurious Behavior in Individuals With Prader-Willi Syndrome
Status: COMPLETED
Conditions: Prader-Willi Syndrome|Self-Injurious Behavior
Interventions: DRUG: Topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: OSU6162 as add-on in SSRI/SNRI-resistant Depression
Status: RECRUITING
Conditions: Depression|Depressive Disorder, Treatment-Resistant|Depressive Disorder|Depressive Episode|Recurrent Depressive Disorder|Recurrent Depression
Interventions: DRUG: OSU6162|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Chronic Renal Failure on Plasma Exposure of Kinase Inhibitors in Patients Treated for Metastatic Kidney Cancer
Status: RECRUITING
Conditions: Kidney Neoplasm
Interventions: OTHER: blood sampling for ITK dosage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Determination the Abuse Potential of Pitolisant in Healthy, Non-Dependent Recreational Stimulant Users
Status: COMPLETED
Conditions: Healthy|Drug Abuse
Interventions: DRUG: Pitolisant|DRUG: Placebos|DRUG: Phentermine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Precision Gait Retraining for Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Gait Disorders, Neurologic
Interventions: DEVICE: mPAD (or TPAD) Pelvic Assist Device|DEVICE: No Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: What is the Antidepressant Mechanism of Action of Quetiapine in Bipolar Depression?
Status: WITHDRAWN
Conditions: Bipolar Depression
Interventions: PROCEDURE: Dietary amino-acid depletion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: PEG-interferon Alfa-2b in Treating Patients With Stage II, Stage III, or Stage IV Head and Neck Cancer That Can Be Removed By Surgery
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: PEG-interferon alfa-2b|PROCEDURE: Conventional surgery|PROCEDURE: Neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gene Therapy for Cardiomyopathy Associated With Friedreich's Ataxia
Status: RECRUITING
Conditions: Friedreich Ataxia|Cardiomyopathy, Secondary
Interventions: GENETIC: Low dose LX2006|GENETIC: Mid Dose LX2006|GENETIC: High Dose LX2006
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Behavioral Disturbances in Patients With Dementia
Status: COMPLETED
Conditions: Dementia|Alzheimer Disease|Dementia, Vascular
Interventions: DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Trial of AD036 in Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: AD036 Dose 1|DRUG: AD036 Dose 2|DRUG: AD036 Dose 3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radicle Relief 2: A Study of Health and Wellness Products on Pain and Health Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain|Neuropathic Pain|Nociceptive Pain
Interventions: DIETARY_SUPPLEMENT: Relief Active Study Product 1.1 Usage|DIETARY_SUPPLEMENT: Relief Active Study Product 1.2 Usage|DIETARY_SUPPLEMENT: Placebo Control Form 1|DIETARY_SUPPLEMENT: Relief Active Study Product 2.1 Usage|DIETARY_SUPPLEMENT: Placebo Control Form 2|DIETARY_SUPPLEMENT: Placebo Control Form 3|DIETARY_SUPPLEMENT: Relief Active Study Product 3.1 Usage|DIETARY_SUPPLEMENT: Relief Active Study Product 3.2 Usage|DIETARY_SUPPLEMENT: Relief Active Study Product 3.3 Usage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study of HEC88473 in Healthy Subjects
Status: COMPLETED
Conditions: Non-alcoholic Steatohepatitis
Interventions: DRUG: HEC88473 injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Epacadostat and Nivolumab in Combination With Immune Therapies in Participants With Advanced or Metastatic Malignancies (ECHO-208)
Status: TERMINATED
Conditions: Solid Tumors
Interventions: DRUG: Epacadostat|DRUG: Nivolumab|DRUG: Ipilimumab|DRUG: Lirilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short-term Effects Kinesiology Tape on Sitting Postural Control in Moderate and Severe Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Kinesiology Taping|Postural Control
Interventions: DEVICE: Kinesiology taping|OTHER: Conventional physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Use of Delayed Release Tablets for Colonic Delivery of Brilacidin in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Brilacidin|DRUG: Placebo|RADIATION: 4Mq 99mTc-DTPA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Clinical Effects of Two New Chlorhexidine Digluconate Formulations: 0.12% and 0.03%.
Status: COMPLETED
Conditions: Dental Plaque|Side Effects
Interventions: DRUG: Placebo: PCB|DRUG: 0.12%NF|DRUG: 0.03%NF|DRUG: PAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pharmacokinetic and Pharmacodynamic Study of Omecamtiv Mecarbil in Healthy Volunteers
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: placebo|DRUG: omecamtiv mecarbil|DRUG: omecamtiv mecarbil|DRUG: omecamtiv mecarbil|DRUG: omecamtiv mecarbil|DRUG: omecamtiv mecarbil|DRUG: omecamtiv mecarbil|DRUG: omecamtiv mecarbil|DRUG: omecamtiv mecarbil|DRUG: omecamtiv mecarbil|DRUG: omecamtiv mecarbil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-procedural 3DCT Versus Angiography Guided PCI for Ostial Right Coronary Artery Lesions
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: 3DCT-scan|OTHER: Angiography guided PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-CD19 Chimeric Antigen Receptor T-Cell Immunotherapy for Chronic Lymphocytic Leukemia (CLL)
Status: RECRUITING
Conditions: B-Cell Chronic Lymphocytic Leukemia|Leukemia, Lymphocytic, Chronic, B-Cell|B-Lymphocytic Leukemia, Chronic
Interventions: BIOLOGICAL: Autologous HuCD19 ( Anti-CD19)CAR T cells|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hip Abductor Strengthening With Proprioceptive Neuromuscular Facilitation
Status: COMPLETED
Conditions: Sports Physical Therapy
Interventions: OTHER: Proprioceptive Neuromuscular Facilitation exercises|OTHER: The Range Of Motion exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of the CRE8 Stent for the Treatment of De Novo Coronary Artery Lesions
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: CRE8 sirolimus-eluting stent|DEVICE: RESOLUTE zotarolimus-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of CGM With Predictive Alarm on Hypoglycemia in Young Patients With T1D.
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: Use of Predictive Alarm for hypoglycaemia or hyperglycaemia|DEVICE: Use of Alarm on Threshold for hypoglycaemia or hyperglycaemia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Transcranial Alternating Current Stimulation (tACS) Preconditioning Effects on Resting and Active Motor Threshold
Status: TERMINATED
Conditions: Understand the Effects of tACS on the Brain
Interventions: DEVICE: tACS or tRNS and TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lung Ultrasound-guided Hemodynamic Optimization
Status: RECRUITING
Conditions: Lung Ultrasound|Goal Directed Therapy|Non-cardiac Surgery
Interventions: DRUG: noradrenaline and vascular filling|PROCEDURE: pulmonary ultrasound after vascular filling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Targeting Driver Oncogenes With a Peptide Vaccine Plus Durvalumab and Tremelimumab for Patients With Biliary Tract Cancers (BTC)
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: mBTC vax [0.3 - 2.4 mg peptide + 0.5 mg Poly-ICLC (Hiltonol)]|DRUG: Durvalumab|DRUG: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Efficacy Study of Primaquine and Methylene Blue
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Sulphadoxine-pyrimethamine|DRUG: 0.25 mg/kg primaquine|DRUG: Dihydroartemisinin-piperaquine|DRUG: Methylene blue|DRUG: Amodiaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Smartphone-based Virtual Reality Exposure and Standard Relaxation Training for Anxiety on an Inpatient Psychiatric Unit
Status: TERMINATED
Conditions: Anxiety|Pain
Interventions: BEHAVIORAL: iPhone Google Cardboard virtual reality meditation/relaxation app|BEHAVIORAL: Standard relaxation training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Impact of Intensive Short-Term Drug Therapy in Patients With Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Diabetes mellitus Type 2 De-escalation treatment (DET)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Test to Predict the Hemolytic Potential of Drugs in G6PD Deficiency
Status: COMPLETED
Conditions: Glucosephosphate Dehydrogenase Deficiency|Favism
Interventions: DRUG: Primaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Systematic Escalation of diuREtics With Natriuresis in Heart Failure Patients: SERENA Trial
Status: NOT_YET_RECRUITING
Conditions: Heart Failure
Interventions: OTHER: Intensive sodiuria-guided diuretic treatment|OTHER: Standard diuretic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Pharmacokinetics, Safety, and Ease of Use of a Portable Metered-Dose Cannabis Inhaler
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Kite Systems cannaHALER cannabis Inhaler.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Using Entecavir to Reduce Hepatitis in Highly Viremic HBV Patients During Anti-tuberculous Treatment
Status: UNKNOWN
Conditions: Hepatitis|Tuberculosis|hepatitisB
Interventions: DRUG: entecavir (BARACLUDE®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Topical Morphine in the Treatment of Severe Local Pain of Chronic Wounds
Status: TERMINATED
Conditions: Local Pain|Chronic Wounds
Interventions: DRUG: Morphine gel|OTHER: Neutral gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Respiratory Muscle Contribution to Blood Pressure During Exercise
Status: COMPLETED
Conditions: Respiratory Muscle|Blood Pressure|Exercise Capacity|Sympathetic Nerve Activity
Interventions: OTHER: Inspiratory Muscle Training (IMT)|OTHER: No Inspiratory Muscle Training (IMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ODM-104 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ODM-104|DRUG: Placebo|DRUG: Entacapone|DRUG: levodopa/carbidopa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Tracheal Tube Cuff Inflation-Deflation Method for Video Assisted Laryngoscope Nasal Intubation in Adults
Status: UNKNOWN
Conditions: Airway Management
Interventions: PROCEDURE: Tracheal Intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial of Point of Care Information in Ambulatory Pediatrics
Status: COMPLETED
Conditions: Acute Otitis Media|Allergic Rhinitis|Sinusitis|Constipation|Pharyngitis|Croup|Urticaria|Bronchiolitis
Interventions: DEVICE: Electronic point-of-care delivery system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Continuous TAP Blocks: Relative Effects of a Basal Infusion vs. Repeated Bolus Doses
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Bolus|DRUG: Basal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MM-121 Combination Therapy in Patients With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: MM-121|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Motivational Interviewing in the Control of Arterial Hypertension and Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Systemic Arterial Hypertension
Interventions: BEHAVIORAL: Motivational interviewing|BEHAVIORAL: Nursing Consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of the Effectiveness and Safety of Injectable Risperidone With That of Risperidone Tablets in the Treatment of Patients With Chronic Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders
Interventions: DRUG: Risperidone Long acting injectable
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Promoting Resilience in Stress Management (PRISM) Intervention: a Multi-site Randomized Controlled Trial for Adolescents and Young Adults With Advanced Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer|Quality of Life|Anxiety|Depression|Hope|Coping Skills|Communication
Interventions: BEHAVIORAL: Promoting Resilience in Stress Management (PRISM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Efficacy and Safety of De-escalated Postoperative Radiotherapy in Locally Advanced HNSCC With pCR/MPR
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: RADIATION: dose-reduced radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Clopidogrel After Surgery for Coronary Artery Disease (CASCADE Trial)
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DRUG: Clopidogrel 75 mg daily|DRUG: water pill daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Compare the Efficacy and Safety of Intranasal Esketamine in Chronic Opioid Refractory Pain
Status: WITHDRAWN
Conditions: Cancer Pain
Interventions: DRUG: esketamine nasal spray|DRUG: placebo nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics and Preliminary Anti-Tumor Activity of Englumafusp Alfa in Combination With Obinutuzumab and in Combination With Glofitamab Following a Pre-Treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma
Status: RECRUITING
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: Englumafusp alfa|DRUG: Obinutuzumab|DRUG: Glofitamab|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: This Study Tests the Safety, Tolerability and How Different Doses of BI 1265162 Are Taken up in the Body of Healthy Men
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1265162|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Dentifrices Containing Arginine Versus Fluoride on Microbial Acid
Status: UNKNOWN
Conditions: Dental Caries
Interventions: DRUG: arginine toothpaste|DRUG: fluoride toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Omega-3 Fatty Acids and Post Traumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: Omega-3 Fatty Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PK Study of Testosterone Nasal Gel (TBS-2) in Healthy Premenopausal Women
Status: COMPLETED
Conditions: Female Sexual Dysfunction
Interventions: DRUG: Low dose testosterone nasal gel, single dose|DRUG: Medium dose testosterone nasal gel, single dose|DRUG: High dose testosterone nasal gel, single dose|DRUG: Medium dose testosterone nasal gel, multiple dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 5-methyltetrahydrofolate Survival and Inflammation in ESRD Patients
Status: COMPLETED
Conditions: Mortality|Hyperhomocysteinemia|Inflammation
Interventions: DRUG: 5-MTHF (5-methyltetrahydrofolate)|DRUG: folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of High-frequency Repetitive Transcranial Magnetic Stimulation on Cerebral Autoregulation in Patients With Cerebral Small Vessel Disease
Status: RECRUITING
Conditions: Transcranial Magnetic Stimulation
Interventions: PROCEDURE: Repetitive transcranial magnetic stimulation|PROCEDURE: Sham repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-arterial Albumin Infusion After Endovascular Therapy for Stroke Patients
Status: NOT_YET_RECRUITING
Conditions: Stroke, Acute Ischemic|Albumin|Endovascular Procedures|Large Vessel Occlusion
Interventions: BIOLOGICAL: Albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EMG Triggered Closed-Loop Stimulation for Spinal Cord Injury Individuals
Status: TERMINATED
Conditions: Spinal Cord Injuries
Interventions: DEVICE: hand movements (signals from thumb muscle) triggered PNS and TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety Study of Nasalfent for Treatment of Breakthrough Cancer Pain in Patients Taking Regular Opioids
Status: COMPLETED
Conditions: Cancers, Pain
Interventions: DRUG: Fentanyl citrate|DRUG: Immediate release morphine sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Tranexamic Acid on Blood Loss After High Tibial Osteotomy
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: High tibial osteotomy|DRUG: Tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Suprascapular Nerve Block as Postoperative Analgesia After Artroscopic Shoulder Surgery
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Ropivacaine hydrochloride|DRUG: Isotonic Saline|DRUG: PCA-pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FTIH Study of ECC0509 in Healthy Volunteers
Status: UNKNOWN
Conditions: Nonalcoholic Steatohepatitis|Osteoarthritis
Interventions: DRUG: Placebo|DRUG: ECC0509|DRUG: Placebo|DRUG: ECC0509
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: OcupApp: Occupational Self-analysis Intervention Through an Mobile Application
Status: NOT_YET_RECRUITING
Conditions: Anxiety Disorder|Depressive Disorder|Occupational Therapy|Mobile App
Interventions: BEHAVIORAL: OcuApp|BEHAVIORAL: Three-part work
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PEN-221 in Somatostatin Receptor 2 Expressing Advanced Cancers Including Neuroendocrine and Small Cell Lung Cancers
Status: COMPLETED
Conditions: Neuroendocrine Tumors|Carcinoma, Small Cell Lung|Neuroendocrine Carcinoma
Interventions: DRUG: PEN-221|DRUG: PEN-221
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Staging of Liver Fibrosis: MR vs Ultrasound
Status: COMPLETED
Conditions: Hepatitis C|Hepatitis B|Nonalcoholic Fatty Liver Disease (NAFLD)|Nonalcoholic Steatohepatitis (NASH)
Interventions: DEVICE: Transient elastography, acoustic radiation force impulse, magnetic resonance elastography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Efficacy and Safety of Oral Oxcarbazepine 300-1200 mg/Day as Adjuvant Therapy in the Treatment of Bipolar Disorder I or II This Study is Not Being Conducted in the United States.
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Oxcarbazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers in Bone Marrow Samples From Patients With Acute Promyelocytic Leukemia
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Promyelocytic Leukemia (M3)|Childhood Acute Promyelocytic Leukemia (M3)
Interventions: OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Using Tacrolimus, Sirolimus and Bortezomib as Acute Graft Versus Host Disease (GVHD) Prophylaxis in Allogeneic Peripheral Blood Stem Cell (PBSC) Transplantation
Status: COMPLETED
Conditions: Graft vs Host Disease|Peripheral Blood Stem Cell Transplantation|Transplantation, Homologous
Interventions: DRUG: Tacrolimus|DRUG: Sirolimus|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irreversible Electroporation(IRE) For Unresectable Urinary Bladder Neoplasms
Status: COMPLETED
Conditions: Urinary Bladder Neoplasms
Interventions: PROCEDURE: Irreversible electroporation (IRE)|DEVICE: NanoKnife
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT