pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Intermediate-term Outcomes of Laparoscopic Pectopexy and Vaginal Sacrospinous Fixation: A Comparative Study
Status: COMPLETED
Conditions: Laparoscopic Pectopexy and Vaginal Sacrospinous Fixation
Interventions: PROCEDURE: vaginal sacrospinous fixation procedure with dr.Aksakal's desta suture carrier|PROCEDURE: Laparoscopic Pectocolpopexy procedure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Etanercept (Recombinant Human Tumor Necrosis Factor Receptor Fusion Protein [TNFR:Fc]) in Children With Juvenile Rheumatoid Arthritis (JRA)
Status: COMPLETED
Conditions: Juvenile Rheumatoid Arthritis
Interventions: DRUG: Etanercept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Esomeprazole vs Omeprazole to Treat Acute Non-Variceal Upper Gastrointestinal Bleeding
Status: COMPLETED
Conditions: Gastrointestinal Hemorrhage
Interventions: DRUG: Esomeprazole IV|DRUG: Omeprazole IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Trastuzumab, Pertuzumab and Tucatinib Without Chemotherapy in HER2-positive Breast Cancer: the TRAIN-4 Study
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Tucatinib|DRUG: Trastuzumab|DRUG: Pertuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prenatal Education About Reducing Labor Stress (PEARLS)
Status: COMPLETED
Conditions: Labor Pain|Tocophobia
Interventions: BEHAVIORAL: Mind in Labor (MIL): Working with Pain in Childbirth|BEHAVIORAL: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Rising Inhalative Doses of BI 1744 CL in Fixed Dose Combination With Tiotropium Bromide in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Single rising doses of BI 1744 CL, solution for oral inhalation|DRUG: Tiotropium, fixed dose, solution for oral inhalation|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Blood Biomarkers as an Indicator of Postoperative Cognitive Dysfunction
Status: UNKNOWN
Conditions: Postoperative Cognitive Dysfunction
Interventions: DIAGNOSTIC_TEST: Blood sampling for assessment of the level of D-Amino Acid Oxidase, D-serine and Serine in blood|DIAGNOSTIC_TEST: Neurocognitive test|DIAGNOSTIC_TEST: Assessment of delirium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Photodynamic Therapy During Surgery in Treating Patients With Pleural Malignancy
Status: WITHDRAWN
Conditions: Stage III Malignant Mesothelioma|Stage IIIB Non-small Cell Lung Cancer|Stage IV Malignant Mesothelioma|Stage IV Non-small Cell Lung Cancer
Interventions: DRUG: porfimer sodium|PROCEDURE: therapeutic conventional surgery|DRUG: photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet-rich Plasma for Eyebrows
Status: RECRUITING
Conditions: Eyebrow Hypotrichosis
Interventions: DEVICE: Platelet Rich Plasma Prep System|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Different Doses of Folic Acid in Combination With Methotrexate in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Folic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 4D-310 in Adults With Fabry Disease and Cardiac Involvement
Status: ACTIVE_NOT_RECRUITING
Conditions: Fabry Disease
Interventions: BIOLOGICAL: 4D-310|BIOLOGICAL: 4D-310|BIOLOGICAL: 4D-310
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Prospective, Randomized, Double-Masked, 12-Week, Parallel Group Study In Pediatric Subjects With Glaucoma.
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Timolol|DRUG: latanoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cannabis Effects on Antiretroviral Therapy Pharmacokinetics and Neurotoxicity
Status: RECRUITING
Conditions: HIV|Cannabis Use
Interventions: DRUG: THC Cannabis|DRUG: CBD Cannabis|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combining Radiotherapy and Temozolomide With Dichloroacetate in Patients With Newly Diagnosed Glioblastoma
Status: WITHDRAWN
Conditions: Glioblastoma
Interventions: DRUG: Dichloroacetate (DCA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Intensity Interval Circuit Training on Resting Metabolic Rate in Overweight Adults
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: OTHER: Exercise training - Phase 1|OTHER: Exercise training - Phase 2|OTHER: Exercise training - Phase 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Immunogenicity of BVRS-GamVac-Combi
Status: UNKNOWN
Conditions: MERS (Middle East Respiratory Syndrome)|MERS
Interventions: DRUG: BVRS-GamVac-Combi|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: COX-2 Inhibitor With Concurrent Chemoradiation in Locally Advanced Head & Neck Carcinoma
Status: UNKNOWN
Conditions: Head and Neck Cancer
Interventions: DRUG: celecoxib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ACE-083 in Patients With Charcot-Marie-Tooth Disease
Status: TERMINATED
Conditions: Charcot-Marie-Tooth Disease
Interventions: DRUG: ACE-083|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy, Radiation Therapy, and Cetuximab Followed by Surgery, Docetaxel, and Cetuximab in Treating Patients With Esophageal Cancer or Gastroesophageal Junction Cancer
Status: TERMINATED
Conditions: Esophageal Cancer
Interventions: DRUG: 5-Fluorouracil|DRUG: Oxaliplatin|DRUG: Cetuximab|DRUG: Docetaxel|PROCEDURE: Surgery|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Clinical Outcomes of Chemotherapy or Androgen-receptor Targeting Agent (Alone or Combined) or Radiotherapy on Primary Tumor in Addition to Androgen Deprivation Therapy in HOrmone-Sensitive Metastatic Prostate Cancer Patients
Status: RECRUITING
Conditions: Prostate Cancer|Hormone Sensitive Prostate Cancer|Metastatic Tumor
Interventions: DRUG: Docetaxel|DRUG: Apalutamide Oral Tablet|DRUG: Enzalutamide Oral Tablet|DRUG: Abiraterone acetate tablets|DRUG: Darolutamide Oral Tablet|RADIATION: radiotherapy|DRUG: Triptorelin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of BMS-986165 Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA)
Status: COMPLETED
Conditions: Active Psoriatic Arthritis
Interventions: OTHER: BMS-986165 Placebo|DRUG: BMS-986165 Dose A|DRUG: BMS-986165 Dose B|DRUG: Ustekinumab|OTHER: Ustekinumab Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cetuximab, Combination Chemotherapy, and Radiation Therapy in Treating Patients With Newly Diagnosed Stage III or Stage IV Head and Neck Cancer That Cannot Be Removed By Surgery
Status: TERMINATED
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: carboplatin|DRUG: cisplatin|DRUG: docetaxel|DRUG: fluorouracil|GENETIC: fluorescence in situ hybridization|GENETIC: molecular genetic technique|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: immunoenzyme technique|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|PROCEDURE: biopsy|RADIATION: 3-dimensional conformal radiation therapy|RADIATION: intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety and Efficacy of ABT-510 in Subjects With Locally Advanced or Metastatic Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Sarcoma, Soft Tissue
Interventions: DRUG: ABT-510 - Thrombospondin-1 mimetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Steady State Global Bioequivalence Study of Amphotericin B Liposome for Injection 50 mg/ Vial in Fed Condition
Status: COMPLETED
Conditions: Visceral Leishmaniasis
Interventions: DRUG: Amphotericin B Liposome|DRUG: AmBisome (Amphotericin B) Liposome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Neurofeedback and Relaxation
Status: UNKNOWN
Conditions: Healthy People
Interventions: BEHAVIORAL: Alpha-based neurofeedback|BEHAVIORAL: Sham neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Non-Myeloablative Allogeneic HSCT From HLA Matched Related or Unrelated Donors for the Treatment of Low Grade B Cell Malignancies
Status: TERMINATED
Conditions: Multiple Myeloma|CLL / SLL|Non Hodgkin's Lymphoma|Waldenstroms|Mantle Cell Lymphoma
Interventions: DRUG: Fludarabine|RADIATION: Total Body Irradiation|OTHER: Infusion of Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of (Telintra®) in Non-Del(5q) Myelodysplastic Syndrome
Status: TERMINATED
Conditions: Myelodysplastic Syndrome (MDS)
Interventions: DRUG: ezatiostat hydrochloride (Telintra®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: R-CHOP Alone vs. R-CHOP Plus Radiotherapy for Localized CD20+ DLBCL
Status: WITHDRAWN
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: R-CHOP|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Pharmacokinetics and Safety Between the Administration of CKD-383 and the Co-administration of CKD-501, D744, and D150
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: CKD-383|DRUG: CKD-501, D744, D150
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hepatic Function and Bile Acid in Preterm Infants Receiving Parenteral Lipids Emulsion
Status: UNKNOWN
Conditions: Preterm Infants
Interventions: DRUG: ClinOleic|DRUG: Intralipid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Programmable and Non-programmable CSF Shunts Among Adult Hydrocephalus Patients With Different Etiologies
Status: COMPLETED
Conditions: Hydrocephalus|Ventriculoperitoneal Shunt Malfunction
Interventions: DEVICE: Programmable valve|DEVICE: Non-programmable valve
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Extended-release Buprenorphine Compared to Sublingual Buprenorphine in Rural Settings (RXR)
Status: NOT_YET_RECRUITING
Conditions: Opioid-Related Disorders|Substance-Related Disorders|Narcotic-Related Disorders
Interventions: DRUG: Injectable extended-release buprenorphine|DRUG: Sublingual buprenorphine-naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Cost: Benefit Ratio of 0, 1, and 2 Medial Branch Blocks for Lumbar Facet Joint Radiofrequency Denervation
Status: COMPLETED
Conditions: Low Back Pain
Interventions: PROCEDURE: Radiofrequency denervation of medial branches|DRUG: 0.5% bupivacaine|DRUG: 2% lidocaine|PROCEDURE: Radiofrequency denervation|PROCEDURE: Radiofrequency denervation|PROCEDURE: Radiofrequency denervation|PROCEDURE: Radiofrequency denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strength and Awareness in Action: an Intervention for Post-Acute TBI Headaches (SAA-TBI)
Status: COMPLETED
Conditions: Traumatic Brain Injury|Post-concussive Headaches
Interventions: BEHAVIORAL: SAA-TBI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk
Status: RECRUITING
Conditions: Peripheral Arterial Disease|Atherosclerosis of Extremities|Inflammation
Interventions: DRUG: Colchicine 0.5 MG Oral Tablet|DRUG: Colchicine-Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Use of Tourniquet Use In Primary Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteo Arthritis Knee|Rheumatoid Arthritis of Knee
Interventions: PROCEDURE: Tourniquet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Muscle Vibration and Joint Position Sense
Status: COMPLETED
Conditions: Vibration; Exposure
Interventions: OTHER: 63 Hz Vibration|OTHER: 42 Hz Vibration|OTHER: Sham vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of RO5186582 Treatment on Cytochrome P450 (CYP) 3A4 Activity in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Midazolam, IV|DRUG: Midazolam, oral|DRUG: RO5186582
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Effects of Osteopathic Manipulations and Muscle Training on the Myoelectric Activity of the Pelvic Floor
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: OTHER: HVLA|OTHER: global osteopathic protocol|OTHER: pelvic floor muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Standing Tutorials on Problem-Based Learning (PBL) Among Undergraduate Students
Status: COMPLETED
Conditions: Problem-Based Learning
Interventions: BEHAVIORAL: Standing during Concept Test|BEHAVIORAL: Standing during regular tutorial session|BEHAVIORAL: Standing during Concept Test and regular tutorial session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: ASTEROID: A Trial of ASTX660 in Combination With Pembrolizumab
Status: RECRUITING
Conditions: Advanced Cancer|Cervical Cancer|Triple Negative Breast Cancer
Interventions: DRUG: ASTX660|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate MK-6096 in the Treatment of Painful Diabetic Neuropathy (PDN) in Adults (MK-6096-021)
Status: COMPLETED
Conditions: Diabetic Neuropathy, Painful
Interventions: DRUG: MK-6096|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ga-68-PSMA-11 in High-risk Prostate Cancer
Status: COMPLETED
Conditions: High-risk Prostate Cancer|Prostate Cancer|Prostate Cancer Metastatic|Lymphnode Metastasis
Interventions: DRUG: Ga-68-PSMA-11
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Open Label, Multi-Center, Follow-on Study Examining the Long-Term Safety and Efficacy of Insulin VIAject™ in Subjects With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: VIAject™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy and Pharmacokinetics of Doxycycline Plus Tauroursodeoxycholic Acid in Transthyretin Amyloidosis
Status: COMPLETED
Conditions: Transthyretin Amyloidosis
Interventions: DRUG: Doxycycline + Tauroursodeoxycholic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Technology Intervention to Support Caregiving for Alzheimer's Disease (I-CARE)
Status: COMPLETED
Conditions: Dementia, Alzheimer Type
Interventions: BEHAVIORAL: ABC Clinical Program|BEHAVIORAL: BCN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sertraline Compared With Hypericum Perforatum (St.John's Wort) in Treating Depression
Status: COMPLETED
Conditions: Depression|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: Zoloft 50 mg|DIETARY_SUPPLEMENT: St. John's Wort 600 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Measures of Gait Efficiency of Three Multi-Axial, Vertical Shock and Energy Storing-Return Prosthetic Feet During Simple & Complex Mobility Activities
Status: COMPLETED
Conditions: Amputation
Interventions: DEVICE: Ossur Variflex prosthetic foot|DEVICE: Ossur Ceterus prosthetic foot|DEVICE: Endolite Elite Blade prosthetic foot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telehealth Delivery (Tele-B6)
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Seropositivity|Bisexuality
Interventions: BEHAVIORAL: Tele-B6|BEHAVIORAL: Delayed intervention (waitlist control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: HPV Serum DNA Levels Predicting Outcome in p16+ Squamous Cell Head and Neck Cancer
Status: COMPLETED
Conditions: Subjects With p16 Positive/HPV Positive Squamous Cell Carcinomas of the Oropharynx
Interventions: OTHER: Obtaining Human tissue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Weight Loss Efficacy of K-757 Alone and in Combination With K-833
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: K-757 and K-833|DRUG: K-757 and matching placebo to K-833|DRUG: Matching placebo to K-757 and matching placebo to K-833
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of UTD1 Injection in Combination With Capecitabine in Patients With Advanced and Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: UTD1 Injection plus capecitabine|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Conditional Cash Transfers to Increase Retention in PMTCT Services in Akwa Ibom State, Nigeria
Status: COMPLETED
Conditions: HIV|HIV Infections|Pregnancy|Infant, Newborn, Diseases
Interventions: BEHAVIORAL: Conditional Cash Transfers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prediction of Progression of Coronary Artery Disease (CAD) Using Vascular Profiling of Shear Stress and Wall Morphology
Status: UNKNOWN
Conditions: Coronary Atherosclerosis|Acute Coronary Syndrome|Percutaneous Coronary Intervention|Endothelial Shear Stress|Arterial Remodeling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preventing Recurrent 'Idiopathic' Acute Pancreatitis Through Laparoscopic Cholecystectomy (PICUS-2)
Status: RECRUITING
Conditions: Idiopathic Acute Pancreatitis
Interventions: PROCEDURE: Laparoscopic cholecystectomy|OTHER: Watchful waiting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab, Fluorouracil, and External-Beam Radiation Therapy in Treating Patients With Stage II or Stage III Rectal Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Rectum|Stage II Rectal Cancer|Stage III Rectal Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: fluorouracil|RADIATION: external beam radiation therapy|PROCEDURE: therapeutic conventional surgery|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Anesthetic Effect of Anterior Middle Superior Alveolar Technique
Status: COMPLETED
Conditions: Periodontal Diseases|Local Anesthesia|Pain
Interventions: PROCEDURE: Anterior middle superior alveolar|PROCEDURE: Supraperiosteal technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Combined Intrarenal Surgery Versus Multi-Tract Percutaneous Nephrolithotomy for Complex Renal Stones:
Status: RECRUITING
Conditions: Stone, Kidney
Interventions: PROCEDURE: Group A (p-PCNL) procedure|PROCEDURE: Group B (s-ECIRS) procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Biliary Tract Cancer
Interventions: DRUG: Volrustomig|DRUG: Bevacizumab|DRUG: Lenvatinib|DRUG: Rilvegostomig|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atrial Deganglionation as a Therapy for Cardiac Surgery Patients With Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Pulsed Field Ablation of epicardial Ganglionated Plexi.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bicalutamide and Ridaforolimus in Men With Prostate Cancer (MK-8669-002)
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: ridaforolimus (MK8669)|DRUG: Comparator: Placebo|DRUG: open-label ridaforolimus (MK8669)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of CMX-2043 for Protection of the Heart and Kidneys in Subjects Undergoing Coronary Angiography
Status: COMPLETED
Conditions: Non STEMI|Unstable Angina
Interventions: DRUG: CMX-2043|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Reliability of the Passive Properties of the Calf Muscles in Healthy Subjects Assessed Using Isokinetic Device
Status: COMPLETED
Conditions: Tendon Injuries|Muscle Tightness
Interventions: DIAGNOSTIC_TEST: Test-Retest reproducibility
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immediate Postplacental Insertion of IUDs at Time of Cesarean Delivery: A Randomized Clinical Trial
Status: COMPLETED
Conditions: Intrauterine Devices|Cesarean Section
Interventions: DEVICE: Immediate Postplacental Placement of an IUD during cesarean delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of NeuroEndoscopic Surgery for IntraCerebral Hemorrhage
Status: RECRUITING
Conditions: Intracerebral Hemorrhage Basal Ganglia
Interventions: PROCEDURE: Endoscopic surgery|OTHER: Medical management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Absorbable Suture vs Permanent Suture in Sacrospinous Ligament Suspension
Status: RECRUITING
Conditions: Pelvic Organ Prolapse|Uterovaginal Prolapse|Vaginal Vault Prolapse|Cystocele
Interventions: OTHER: Absorbable Suture and Permanent Suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Crossover Study to Assess the Efficacy of PT003 With and Without a Valved Holding Chamber in Subjects With Moderate to Severe COPD
Status: COMPLETED
Conditions: COPD
Interventions: DEVICE: GFF MDI (PT003) with Aerochamber|DEVICE: GFF MDI (PT003) without Aerochamber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Effects of Lutein/Zeaxanthin and Omega-3- Supplementation on Optical Density of AMD Patients (LUTEGA)
Status: COMPLETED
Conditions: Age Related Maculopathy
Interventions: DIETARY_SUPPLEMENT: Lutein/ Zeaxanthin + Omega-3-FA|DIETARY_SUPPLEMENT: Lutein/ Zeaxanthin + Omega-3-FA|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study Assessing Risk Factors for Abdominal Pain in Children With Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Inflammatory Bowel Disease
Interventions: GENETIC: Genomic DNA|GENETIC: RNA analysis|GENETIC: Microbiome|OTHER: Calprotectin|OTHER: Pain questionnaires|OTHER: Anxiety/Depression Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treximet (Sumatriptan/Naproxen Sodium), Formerly Known as TREXIMA, for Menstrual Migraine in Women With Dysmenorrhea
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: DRUG: sumatriptan succinate/naproxen sodium|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Loratadine for the Reduction of G-CSF Induced Bone Pain in Patients With Multiple Myeloma Undergoing Stem Cell Mobilization
Status: RECRUITING
Conditions: Plasma Cell Myeloma
Interventions: DRUG: Loratadine|OTHER: Placebo|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neural Prediction to Enhance Language
Status: RECRUITING
Conditions: Bilateral Sensorineural Hearing Loss|Speech and Language Development Delay Due to Hearing Loss|Social Communication
Interventions: BEHAVIORAL: Parent-Implemented Communication Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Flexible and Integrative Psychiatric Care Model in Child and Adolescent Psychiatry
Status: RECRUITING
Conditions: Mental Health Care|Cross-sectoral Treatment|Flexible and Integrated Treatment|FIT64b|Child and Adolescent Psychiatry|Evaluation|Cohort Study
Interventions: OTHER: FIT64b model project
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Different Anesthetic Strategies on Postoperative Cognitive Function and Delirium in Patients Undergoing Cardiac Surgery
Status: UNKNOWN
Conditions: Delirium|Condition|Anesthesia
Interventions: PROCEDURE: Precision cardiac anesthesia|PROCEDURE: Conventional cardiac anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Implementation of a Comprehensive Multilevel Virtual Oncology Program Among Veterans Diagnosed With Lung, Colorectal, Prostate, and Breast Cancers in the US Department of Veterans Affairs
Status: RECRUITING
Conditions: Lung Cancer Diagnosis|Colorectal Cancer (Diagnosis)|Prostate Cancer Diagnosis|Breast Cancer Diagnosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of 0.75% Phentolamine Ophthalmic Solution in Subjects With Post-refractive Surgery Visual Disturbances
Status: RECRUITING
Conditions: Mesopic Vision|Night Vision Loss
Interventions: DRUG: phentolamine ophthalmic solution 0.75%, a non-selective alpha-1 and alpha-2 adrenergic antagonist|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study to Assess Efficacy of Intralesional MMR Vaccine and Intralesional Vitamin D3 in Treatment of Warts
Status: COMPLETED
Conditions: Verruca Viral
Interventions: DRUG: Measles-Mumps-Rubella Vaccine|DRUG: Vit D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fluid Management in Patients Undergoing Cardiac Surgery
Status: COMPLETED
Conditions: Critical Illness
Interventions: PROCEDURE: perioperative hemodynamic management with vasoactive medications (norepinephrine, adrenaline ect)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alexithymia in Ankylosing Spondylitis
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: DIAGNOSTIC_TEST: Bath Ankylosing Spondylitis Metrology Index (BASMI)|DIAGNOSTIC_TEST: Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)|DIAGNOSTIC_TEST: Bath Ankylosing Spondylitis Functional Index (BASFI)|DIAGNOSTIC_TEST: Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL)|DIAGNOSTIC_TEST: Toronto Alexithymia Scale-20 (TAS-20)|DIAGNOSTIC_TEST: Beck's Depression Inventory (BDI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Study for the BONGO NASAL Expiratory Positive Airway Pressure (EPAP) Device in the Treatment of Obstructive Sleep Apnea (OSA)
Status: TERMINATED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: BONGO NASAL EPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation and Perioperative Neurocognitive Disorders
Status: NOT_YET_RECRUITING
Conditions: Postoperative Cognitive Dysfunction|Repetitive Transcranial Magnetic Stimulation
Interventions: PROCEDURE: repetitive transcranial magnetic stimulation|PROCEDURE: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Midodrine for the Treatment of Refractory Hypotension
Status: COMPLETED
Conditions: Hypotension|Critical Illness
Interventions: DRUG: Midodrine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Breastfeeding Support System
Status: COMPLETED
Conditions: Preterm|Breastfeeding|Breast Milk|Breastfeeding Support System
Interventions: OTHER: Routine nursing care|OTHER: breastfeeding support system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Halliwick and Aquatic Exercises in Spastic Cerebral Palsy
Status: COMPLETED
Conditions: Spastic Cerebral Palsy
Interventions: OTHER: aquatic exercises|OTHER: halliwick exercise programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MRSI to Predict Response to RT/TMZ ± Belinostat in GBM
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma Multiforme of Brain
Interventions: RADIATION: Standard Radiation Therapy|DRUG: Standard Temozolomide|DRUG: Belinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide (Revlimid) in Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Leukemia
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amantadine Versus Ritalin in the Treatment of Attention Deficit Hyperactivity Disorder (ADHD)
Status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Amantadine|DRUG: ritalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study of Abiraterone Acetate in Male Participants With Impaired Renal Function Compared to Individuals With Normal Renal Function
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: DRUG: Abiraterone acetate: participants with end-stage renal disease|DRUG: Abiraterone acetate: matched control participants with normal renal function
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerability, Safety and Efficacy of Flexibly Dosed Paliperidone ER in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Paliperidone ER
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Antidepressant + SPD489 (Lisdexamfetamine dimesylate) 10 mg|DRUG: Antidepressant + SPD489 (Lisdexamfetamine dimesylate) 30 mg|DRUG: Antidepressant + SPD489 (Lisdexamfetamine dimesylate) 50 mg|DRUG: Antidepressant + SPD489 (Lisdexamfetamine dimesylate) 70 mg|DRUG: Antidepressant + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CASPAR : Clopidogrel and Acetyl Salicylic Acid in Bypass Surgery for Peripheral ARterial Disease
Status: COMPLETED
Conditions: Arterial Occlusive Diseases
Interventions: DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Tidal Volume in Patients With "de Novo" Acute Hypoxemic Respiratory Failure
Status: COMPLETED
Conditions: Acute Hypoxemic Respiratory Failure
Interventions: DEVICE: Ventimask|DEVICE: High Flow Nasal cannula (HFNC)|DEVICE: Helmet CPAP|DEVICE: Non Invasive Ventilation (NIV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [18F]F-AraG PET Imaging to Visualize Tumor Infiltrating T-cell Activation in Non-small Cell Lung Cancer.
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DIAGNOSTIC_TEST: [18F]F-AraG PET-scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Components of Placebo Effects in Sadness
Status: COMPLETED
Conditions: Dysphoric Mood
Interventions: OTHER: OLP scientifically-objective|OTHER: OLP personally-affective|OTHER: DP scientifically-objective|OTHER: DP personally-affective
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Evaluation of Chang Geng Healthy Drink on Patients With Non-alcoholic Fatty Liver Disease
Status: NOT_YET_RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: OTHER: Chang Geng Healthy Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nicotine, Non-Smokers With and Without ADHD, and Genetics Study
Status: COMPLETED
Conditions: Non-smoker|ADHD
Interventions: DRUG: Nicotine nasal spray|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Partially HLA-Matched Irradiated Allogeneic Cellular Therapy After Reduced Intensity Total Body Irradiation
Status: TERMINATED
Conditions: Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: Irradiated haploidentical allogeneic lymphocytes|RADIATION: total-body irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IV Steroids Versus Steroids Included in Block for Orthopedic Lower Limb Surgery
Status: COMPLETED
Conditions: Lower Limb Injury
Interventions: DRUG: Placebos|DRUG: Dexamethasone Sodium Phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Horticultural Therapy on Mental Health and Burnout Levels of Nursing Home Workers
Status: NOT_YET_RECRUITING
Conditions: Horticultural Therapy|Anxiety|Depression|Stress|Caregivers
Interventions: OTHER: Assigned Interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Compare the Efficacy and Safety of Oral AT1001 and Enzyme Replacement Therapy in Patients With Fabry Disease
Status: COMPLETED
Conditions: Fabry Disease
Interventions: DRUG: migalastat hydrochloride|BIOLOGICAL: agalsidase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Shunt Occlusion on Organ Functions in Hyperammonemic Patients With Cirrhosis Having Porto-systemic Shunt.
Status: COMPLETED
Conditions: Cirrhosis
Interventions: PROCEDURE: Shunt Occlusion|DIETARY_SUPPLEMENT: Standard Medical Treatment (SMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: iPad Technology for HOME Rehabilitation in Patients After Stroke: iHOME Acute/Chronic
Status: COMPLETED
Conditions: Fine Motor Function Deficit and Visual Neglect Post-stroke
Interventions: OTHER: iPad Intervention|OTHER: Standard/ Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Biological Standardization of Allergen Extracts of Pollens of Betula Pendula, Phleum Pratense and Mite Extract of Dermatophagoides Pteronyssinus
Status: COMPLETED
Conditions: Allergy
Interventions: OTHER: Extracts of allergens
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of HPN-100 for the Treatment of Adults With Urea Cycle Disorders
Status: COMPLETED
Conditions: Urea Cycle Disorders
Interventions: DRUG: HPN-100|DRUG: Buphenyl (NaPBA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Hypersensitivity to Female Sex Hormones in Women With Unexplained Recurrent Pregnancy Loss
Status: UNKNOWN
Conditions: Abortion, Recurrent
Interventions: DRUG: Skin test panel|DRUG: Skin test panel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison Between Surgical Access and Repeated Applications of APDT
Status: UNKNOWN
Conditions: Aggressive Periodontitis, Generalized
Interventions: PROCEDURE: Open flap debridement|PROCEDURE: Repeated application of aPDT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Respiratory Muscle Training and Patient Education on Chronic Constipation Outcomes
Status: RECRUITING
Conditions: Constipation|Constipation - Functional|Dyssynergia
Interventions: OTHER: Hybrid Telehealth Program: Respiratory Muscle Training and Patient Education|OTHER: Standard Physical Therapy Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of 18F-Fluoro-PEG6-IPQA
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: 18F-PEG6-IPQA|PROCEDURE: Positron emission tomography (PET)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Latency in Pulmonary Tuberculosis
Status: COMPLETED
Conditions: Pulmonary Tuberculosis
Interventions: DRUG: Moxifloxacin, Isoniazid, Rifampicin Pyrazinamide, Ethambutol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection and Localization of Carcinoma Using High Resolution Transrectal Imaging - Proof of Concept Study
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DEVICE: ProxiScan|DEVICE: Magnetic Resonance Imaging|DEVICE: SPECT-CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Women's Estrogen/Progestin Lipid Lowering Hormone Atherosclerosis Regression Trial (WELL-HART)
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Disease|Heart Diseases|Myocardial Ischemia|Postmenopause
Interventions: DRUG: estrogen replacement therapy|DRUG: hormone replacement therapy|DRUG: estradiol|DRUG: medroxyprogesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Timing of Laparoscopic Cholecystectomy After Endoscopic Retrograde Cholangiography for Acute Biliary Pancreatitis
Status: UNKNOWN
Conditions: Cholelithiasis Associated With Common Bile Duct Stones
Interventions: OTHER: tissue sampling from peritoneum of the gallbladder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Thoracic Diameter and Food Intake on Fibroscan® Results
Status: COMPLETED
Conditions: Liver Stiffness
Interventions: DIAGNOSTIC_TEST: Fibroscan Touch 502 M probe|DIAGNOSTIC_TEST: Fibroscan Touch 502 S probe
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Assess the Adverse Events and How Intravenously Infused Livmoniplimab in Combination With Budigalimab Moves Through the Bodies of Adult Chinese Participants With Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC)
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma (HCC)
Interventions: DRUG: Livmoniplimab|DRUG: Budigalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Varicella Zoster Vaccine in Patients With Plaque Psoriasis Treated With Biologic Therapy
Status: TERMINATED
Conditions: Psoriasis
Interventions: DRUG: Varicella Zoster Vaccine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION