pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Open Label Study of Subcutaneous Homoharringtonine (Omacetaxine Mepesuccinate) in Patients With Advanced CML
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Omacetaxine mepesuccinate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chikungunya Vaccine (V184) Study in Previously Exposed Adults (V184-006)
Status: COMPLETED
Conditions: Chikungunya Virus Infection
Interventions: BIOLOGICAL: V184|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Brentuximab Vedotin And Bevacizumab In Refractory CD-30 Positive Germ Cell Tumors
Status: TERMINATED
Conditions: Germ Cell Tumor
Interventions: DRUG: Brentuximab Vedotin|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postprandial Metabolism After Bariatric Surgery in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes|Obese
Interventions: PROCEDURE: biliopancreatic diversion with duodenal switch|PROCEDURE: sleeve gastrectomy|OTHER: liquid meal|RADIATION: PET/scan|OTHER: [7,7,8,8-2H]-palmitate|DEVICE: indirect calorimetry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel and Oxaliplatin in Treating Patients With Metastatic or Recurrent Solid Tumor
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: docetaxel|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effects of Short-Chain Fatty Acids in Psychosocial Stress-Induced Impairment on Core Executive Functions
Status: NOT_YET_RECRUITING
Conditions: Executive Function
Interventions: DIETARY_SUPPLEMENT: Short Chain Fatty Acids (SCFAs).|DIETARY_SUPPLEMENT: Placebo|OTHER: Maastricht Acute Stress Task|OTHER: No-stress control task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Axillary Staging in Early Breast Cancer: SNB vs PET/MRI
Status: RECRUITING
Conditions: Breast Cancer|Sentinel Lymph Node|Early-stage Breast Cancer
Interventions: DIAGNOSTIC_TEST: PET/MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Antimicrobial Activity of Platelet Rich Plasma (PRP) in Acne Vulgaris
Status: UNKNOWN
Conditions: Platelet-Rich Plasma|Acne Vulgaris
Interventions: COMBINATION_PRODUCT: PRP|OTHER: Chemical peeling (Salycilic acid)|OTHER: Chemical peeling (Jessener's solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: N-GAL Allows Intensive Treatment of Contrast Induced Nephropathy
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Intensive treatment with sodium bicarbonate|DRUG: Standard treatment with saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Brief Telehealth CBT-I Intervention in the Context of the COVID-19 Pandemic
Status: COMPLETED
Conditions: Sleep Disturbance|Insomnia
Interventions: BEHAVIORAL: Remote Cognitive Behavioral Therapy for Insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Transcutaneous Auricular Vagus Nerve Stimulation Treatment on Reflux Esophagitis
Status: COMPLETED
Conditions: Reflux Esophagitis
Interventions: DEVICE: Transcutaneous Auricular Vagus Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sealing Moderate Coronary Saphenous VEin Graft Lesions With Paclitaxel-Eluting Stents
Status: TERMINATED
Conditions: Coronary Artery Bypass Grafting
Interventions: DEVICE: Paclitaxel eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunonutrition and Carbohydrate Loading Strategies in Breast Reconstruction
Status: COMPLETED
Conditions: Wound Complication|Wound Heal|Complications Wound|Surgical Wound Infection|Surgical Site Infection|Breast Cancer|Mastectomy; Lymphedema
Interventions: DIETARY_SUPPLEMENT: Impact Advanced Recovery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Disease Modifying Antirheumatic Drugs Therapy in Patients With RA Failing Methotrexate Monotherapy
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Methotrexate|DRUG: Leflunomide|DRUG: Hydroxychloroquine|DRUG: Prednisolone|DRUG: Folic Acid|DRUG: Sulfasalazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Reactogenicity of Pneumococcal Polysaccharide and Conjugate Vaccines in Native Elders
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: Pneumococcal polysaccharide vaccine|BIOLOGICAL: Pneumococcal conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Genetic Polymorphisms of Drug Transporters and Orphan Nuclear Receptors on Treatment Effects of Irinotecan
Status: UNKNOWN
Conditions: Colorectal Neoplasms|Secondary
Interventions: DRUG: irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Stem Cell Injection to Treat Heart Damage During Open Heart Surgery
Status: TERMINATED
Conditions: Heart Disease|Ischemic Heart Disease|Coronary Artery Disease|Coronary Artery Disease (CAD)
Interventions: OTHER: Cell Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Bone-marrow Derived Mesenchymal Stromal Cells (MSC) for New Onset Chronic Lung Allograft Dysfunction
Status: COMPLETED
Conditions: Chronic Lung Allograft Dysfunction (CLAD)
Interventions: DRUG: Bone-marrow derived MSCs|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 4-Week, Multiple-dose, Dose-escalating Study In Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Placebo|DRUG: PF-06882961|DRUG: PF-06882961|DRUG: PF-06882961|DRUG: PF-06882961|DRUG: PF-06882961|DRUG: PF-06882961|DRUG: PF-06882961|DRUG: PF-06882961
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vorasidenib Expanded Access Program
Status: AVAILABLE
Conditions: Glioma|Recurrence|Disease Attributes|Pathologic Processes|Neoplasms, Neuroepithelial|Neuroectodermal Tumors|Neoplasms, Germ Cell and Embryonal|Neoplasms by Histologic Type|Neoplasms|Neoplasms, Glandular and Epithelial|Neoplasms, Nerve Tissue
Interventions: DRUG: Vorasidenib
Study Type: EXPANDED_ACCESS
Clinical trial: Loteprednol Etabonate 0.25% for Prevention of Cornea Transplant Rejection
Status: COMPLETED
Conditions: Corneal Endothelial Dystrophy|Corneal Edema
Interventions: DRUG: loteprednol etabonate 0.25% ophthalmic suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Effect of Palm Olein Free Formula on Intestinal Flora and Gastrointestinal Tolerance
Status: COMPLETED
Conditions: Feeding; Disorder, Nonorganic Origin|Calcium Disorder|Intestinal Bacteria Flora Disturbance
Interventions: OTHER: Feeding with palm olein formula
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of GQ1005 in Subjects With HER2-Expressing Advanced Solid Tumors
Status: RECRUITING
Conditions: HER2 Expressing or Mutated Advanced Malignant Solid Tumors
Interventions: DRUG: GQ1005
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety, Tolerability, Pharmacokinetics and Activity of Oraxol in Subjects With Advanced Malignancies
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: Oraxol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PECS II Block and Single Port Robot-assisted Transaxillary Thyroidectomy
Status: NOT_YET_RECRUITING
Conditions: Thyroid Cancer
Interventions: PROCEDURE: Pectoral nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast)
Status: COMPLETED
Conditions: Lymphatic Filariasis|Onchocerciasis|Soil Transmitted Helminth (STH) Infections
Interventions: DRUG: Annual versus Semiannual Albendazole plus Ivermectin MDA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Virtual Reality Mediated Upper Extremity rehabilitationPatients With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Upper Extremity Paresis
Interventions: OTHER: Virtual reality mediated upper extremity rehabilitation|OTHER: Classical exercise therapy for upper extremities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of ATG-101 in Patients With Metastatic/Advanced Solid Tumors and Mature B-cell Non-Hodgkin Lymphomas
Status: RECRUITING
Conditions: Advanced Solid Tumor|Metastatic Solid Tumor|Mature B-cell Non-Hodgkin Lymphoma
Interventions: DRUG: ATG-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of 2-DeNT Oral Topical Powder on Minor Recurrent Aphthous Ulcer
Status: COMPLETED
Conditions: Minor Recurrent Aphthous Stomatitis Lesions
Interventions: DRUG: 2-DeNT powder|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficiency of Linagliptin (Trajenta) in the Setting of Internal Medicine Department
Status: UNKNOWN
Conditions: DM2
Interventions: DRUG: Linagliptin and Basal Insulin|DRUG: Basal Insulin and Bolus Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Multi-center, Open-label, Paired Controlled, Crossover In Vivo Study
Status: TERMINATED
Conditions: Healthy
Interventions: BIOLOGICAL: Autologous apheresis Platelet Components, prepared with the INTERCEPT Blood System for Platelets.|BIOLOGICAL: Autologous apheresis Conventional untreated Platelet Components
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Compare the Pharmacokinetics, Pharmacodynamics and Safety/Tolerability of LC51-0255 Film-coated Tablet (SG85) With LC51-0255 Uncoated Tablet (SG82) in Healthy Subjects
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Film-coated tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: PAPR: PAP + MBSR for Front-line Healthcare Provider COVID-19 Related Burnout
Status: RECRUITING
Conditions: Depression|Burnout, Professional
Interventions: DRUG: Psilocybin|BEHAVIORAL: Mindfulness-Based Stress Reduction (MBSR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided QLB Versus Laparoscopic Superior Hypogastric Plexus Block for Postoperative Analgesia After Laparoscopic Hysterectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Post Hysterectomy Pain
Interventions: PROCEDURE: Quadratus Lamborum versus superior hypogatric
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of LAS41004 Formulations in a Non-occlusive Psoriasis Plaque Test
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: LAS41004
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pedicled Buccal Periosteal Flap for the Closure of Oro-antral Fistula
Status: COMPLETED
Conditions: Oroantral Fistula
Interventions: PROCEDURE: A Pedicled Buccal Periosteal Flap for the Closure of Oro-antral Fistula
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Respiratory Depression During an Analgosedation Combining Remifentanil and Ketamine in TCI for Oocyte Retrieval
Status: UNKNOWN
Conditions: Oocyte Retrieval|Sedation, Conscious|Ventilatory Depression
Interventions: DRUG: Ketamine 150 ng/ml|DRUG: Remifentanil|PROCEDURE: Oocyte retrieval|DRUG: Ketamine 200 ng/ml
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Low Dose Dexamethasone in Supraclavicular Blocks
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Osteoarthritis|Nerve Entrapment|Ligament Injury
Interventions: DRUG: Control intervention (no dexamethasone)|DRUG: Peri-neural Dexamethasone 1 mg|DRUG: Intravenous Dexamethasone 1 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CPAP in Treating Obstructive Sleep Apnea in Patients With Polycythemia Vera or Essential Thrombocythemia
Status: TERMINATED
Conditions: CALR Gene Mutation|Essential Thrombocythemia|JAK2 Gene Mutation|MPL Gene Mutation|Obstructive Sleep Apnea Syndrome|Polycythemia Vera
Interventions: PROCEDURE: Continuous Positive Airway Pressure|OTHER: Patient Observation|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Alfacalcidol Compared to Calcitriol for Treatment of Secondary Hyperparathyroidism
Status: COMPLETED
Conditions: Secondary Hyperparathyroidism|End Stage Renal Disease
Interventions: DRUG: alfacalcidol and calcitriol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FGF23 Reduction : Efficacy of a New Phosphate Binder in CHronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Renal Failure
Interventions: DRUG: Placebo|DRUG: Sevelamer carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modified Enhanced Recovery After Oblique Lateral Interbody Fusion Surgery
Status: RECRUITING
Conditions: Lumbar Spondylosis|Lumbar Spinal Stenosis|Lumbar Disc Herniation
Interventions: OTHER: Modified ERAS protocol|OTHER: routine protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgical Resection of the Greater Splanchnic Nerve in Subjects Having Heart Failure With Preserved Ejection Fraction
Status: COMPLETED
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: PROCEDURE: Surgical Resection of the Greater Splanchnic Nerve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0528 Lapatinib and Everolimus in Treating Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: everolimus|DRUG: lapatinib ditosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hearing Aid and Individuals With Cognitive Disorders
Status: RECRUITING
Conditions: Presbycusis, Bilateral|Alzheimer Disease 2 Due to Apoe4 Isoform
Interventions: DEVICE: Audiologist-based fitting|DEVICE: Service-only Fitting|DEVICE: Device-only fitting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Fixed Dose Combination of 2.5 mg Saxagliptin/850 mg Metformin Tablet Relative to 2.5 mg Onglyza and 850 mg Glucophage Tablets Co-Administered
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: saxagliptin|DRUG: metformin|DRUG: saxagliptin + metformin (FDC tablet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Long-term Study of Efficacy/Safety of Adapalene/Benzoyl Peroxide Topical Gel in Acne Vulgaris Subjects
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Adapalene/Benzoyl Peroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paracetamol and Metamizole With SPI-guided Anaesthesia for VRS
Status: COMPLETED
Conditions: Vitreoretinal Surgeries|Postoperative Nausea and Vomiting|Postoperative Pain
Interventions: DRUG: Metamizol|DRUG: paracetamol|DRUG: paracetamol and metamizole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety, Immunogenicity and Efficacy Study of Inactivated Whole Cell Shigella Flexneri 2a Vaccine With and Without dmLT in Adults
Status: WITHDRAWN
Conditions: Shigella Sonnei Dysenteries
Interventions: BIOLOGICAL: Shigella flexneri 2a whole cell (Sf2aWC) vaccine and double mutant E. coli heat labile toxin (dmLT)|BIOLOGICAL: Shigella flexneri 2a whole cell (Sf2aWC) vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effects of Galvanic Vestibular Stimulation (GVS) on Spatial Neglect
Status: UNKNOWN
Conditions: Spatial Neglect After Right Brain-damage
Interventions: DEVICE: Direct current galvanic vestibular stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Intervention to Improve Cardiometabolic Risk Profile in Individuals With Type 2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2|Cardiovascular Diseases
Interventions: BEHAVIORAL: Personalized Dietary Advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rosuvastatin Effect on Atherosclerotic Plaque Metabolism
Status: COMPLETED
Conditions: Cardiovascular Diseases|Atherosclerosis|Molecular Imaging
Interventions: DRUG: Rosuvastatin Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Midline vs. Paramedian Approaches for US-assisted Spinal Anesthesia
Status: COMPLETED
Conditions: Anesthesia, Spinal|Ultrasonography
Interventions: PROCEDURE: ultrasound-assisted midline approach|PROCEDURE: ultrasound-assisted paramedian approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Upper Limb-based Movement Priming for Lower Limb Neuroplasticity & Motor Recovery in Stroke
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: OTHER: Upper limb-based movement priming (UL-priming)|OTHER: Lower limb-based movement priming (LL-priming)|OTHER: Sham priming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing the Efficacy and Safety of Insulin Glargine (Basal Insulin)/Lixisenatide (GLP-1 Receptor Agonist) Combination (Soliqua™) in Patients With Type 2 Diabetes Mellitus (T2DM)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: INSULIN GLARGINE/LIXISENATIDE HOE901/AVE0010
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of E3810 for Japanese Subjects With Functional Dyspepsia (SAMURAI Study: Suppression of Acid Milieu With Rabeprazole Improving Functional Dyspepsia ) (Study E3810-J081-204)
Status: COMPLETED
Conditions: Functional Dyspepsia
Interventions: DRUG: Rabeprazole|DRUG: Rabeprazole|DRUG: Rabeprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Remote Time-restricted EAting DeliverY
Status: ACTIVE_NOT_RECRUITING
Conditions: Metabolic Disturbance
Interventions: BEHAVIORAL: Standardized TRE Protocol|BEHAVIORAL: Personalized TRE Protocol|BEHAVIORAL: External Support for TRE|BEHAVIORAL: Peer Support for TRE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Augmenting Benzodiazepine Receptor Agonist Deprescribing With Acupuncture and Yoga Among Older Adults
Status: RECRUITING
Conditions: Anxiety|Insomnia|Benzodiazepine|Deprescription
Interventions: OTHER: Acupuncture|OTHER: Yoga|OTHER: Deprescribing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Influenza Virus Vaccines in Children and Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: 2009-2010 Trivalent Influenza Virus Vaccine|BIOLOGICAL: 2008-2009 Trivalent Influenza Virus Vaccine|BIOLOGICAL: Quadrivalent Influenza Virus Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of an Ablation Catheter for the Treatment of Pancreatic Premalignant Cyctic Lesions.
Status: UNKNOWN
Conditions: Pancreatic Cancer|Pancreatic Neuroendocrine Tumor|Pancreatic Cyst|Pancreatic Cancer Stage
Interventions: DEVICE: EUSRA RF electrode
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alternate Nostril Breathing Training in Geriatrics With Glaucoma and High Blood Pressure
Status: RECRUITING
Conditions: Primary Open Angle Glaucoma|Hypertension
Interventions: BEHAVIORAL: breathing exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Conversion Therapy of Hyperthermic Intraperitoneal Chemotherapy Plus Chemotherapy and Chemotherapy in Stage IV Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: PROCEDURE: Comparing Hyperthermic Intraperitoneal Chemotherapy|DRUG: Paclitaxel|DRUG: S1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Day-case Versus Inpatient Laparoscopic Supracervical Hysterectomy
Status: COMPLETED
Conditions: Hysterectomy
Interventions: PROCEDURE: day-case laparoscopic supracervical hysterectomy|PROCEDURE: inpatient LSH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction IBI110 and Sintilimab With Chemotherapy In LA HNSCC
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Sintilimab|DRUG: IBI110|DRUG: Paclitaxel|DRUG: Cis Platinum|PROCEDURE: Surgery|RADIATION: Adjuvant radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of MGA271 in Refractory Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Melanoma|Renal Cell Carcinoma|Triple-negative Breast Cancer|Head and Neck Cancer|Bladder Cancer|Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: MGA271
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Banning Menthol Flavorant on Cigarette and E-Cigarette Use
Status: COMPLETED
Conditions: Tobacco Use Disorder
Interventions: OTHER: Menthol ban on cigarettes|OTHER: Menthol ban on cigarettes and e-cigarettes|OTHER: No menthol ban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Investigate the Effect of DWP16001 as add-on Therapy to Drug A in Patients With Type 2 Diabetes Mellitus
Status: RECRUITING
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: DWP16001 0.3mg|DRUG: DWP16001 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of MMV371 LAI in Healthy Participants
Status: NOT_YET_RECRUITING
Conditions: Malaria,Falciparum
Interventions: DRUG: MMV371 LAI|DRUG: Placebo for MMV371
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Cemiplimab in Patients With Type of Skin Cancer Stage II to IV Cutaneous Squamous Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Cutaneous Squamous Cell Carcinoma
Interventions: DRUG: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ivermectin to Prevent SARS-CoV-2 (COVID-19) Hospitalisation in Subjects Over 50
Status: TERMINATED
Conditions: COVID-19|SARS-CoV-2
Interventions: DRUG: Ivermectin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment for Youth (Ages 8 to 16 Years Old) With Misophonia (U-HEAR)
Status: UNKNOWN
Conditions: Misophonia
Interventions: BEHAVIORAL: Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents (UP-C/A) for youth with misophonia|BEHAVIORAL: Psychoeducation and Relaxation Therapy (PRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Efficacy Against Otitis Media in Children With 11 Valent Pneumococcal Vaccine
Status: TERMINATED
Conditions: Hepatitis A
Interventions: BIOLOGICAL: undecavalent pneumococcal-protein D conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Monitoring Nociception Using NoL Index to Reduce Opioid-Related Complications in Laparoscopic Abdominal Surgery
Status: NOT_YET_RECRUITING
Conditions: Postoperative Opioid-related Complications
Interventions: DEVICE: Nociception Level (NoL) Monitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Effectiveness of In-office Bleaching Activated With a LED/Laser Device
Status: COMPLETED
Conditions: Tooth Discoloration
Interventions: PROCEDURE: in-office bleaching with/without light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Belgian-Italian Trial to Evaluate the Efficacy and Safety of Below The Knee (BTK) Treatment With the Luminor 14 Paclitaxel Coated Percutaneous Transluminal Angioplasty Balloon Catheter of iVascular
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: Luminor-14 Paclitaxel eluting balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Reuteri in the Supportive Therapy of Periodontitis
Status: RECRUITING
Conditions: Periodontal Diseases
Interventions: DIETARY_SUPPLEMENT: Probiotic: Lactobacillus Reuteri|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Preoxygenation Time on End-tidal Oxygen Concentration and on Hypoxic Events Occurring After Intubation in the Intensive Care Unit.
Status: WITHDRAWN
Conditions: Preoxygenation|Intubation|Intensive Care Unit
Interventions: OTHER: Preoxygenation|OTHER: Preoxygenation (longer)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Sevoflurane on Cerebral CO2 Sensitivity and Systemic Arteries
Status: COMPLETED
Conditions: Sevoflurane Anesthesia
Interventions: PROCEDURE: Partial pressure of CO2 at the end of an exhaled breath|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Narval CC Mandibular Repositioning Device in the Second-line Treatment of Severe Obstructive Sleep Apnea Hypopnea (OSAH)
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndrome
Interventions: DEVICE: ORM Narval MRD
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Propiverine in Children Suffering From Non-Neurogenic Overactive Bladder and Urinary Incontinence
Status: COMPLETED
Conditions: Overactive Bladder|Urinary Incontinence|Children
Interventions: DRUG: Mictonetten 5 mg, coated tablet|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Trametinib and Panitumumab in RAS/RAF Wild Type Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|KRAS Wildtype|NRAS Wildtype|BRAF Wildtype
Interventions: DRUG: Trametinib|DRUG: Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effect of Isotretinoin in Regulatory T-cell Function in Adverse Cutaneous Drug Eruptions (ACDEs): A Pilot Study
Status: WITHDRAWN
Conditions: Toxic Epidermal Necrolysis
Interventions: DRUG: Isotretinoin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Digital 3D Printed Temporary Removable Partial Denture.
Status: RECRUITING
Conditions: Partial-edentulism|Temporary Partial Denture|3D Printing|Oral Health Related Quality of Life
Interventions: PROCEDURE: The conventional heat pressing temporary flexible maxillary removable partial denture|PROCEDURE: 3D-printed and digitally designed temporary flexible maxillary removable partial denture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Pregabalin (Lyrica) for the Treatment of Nerve Pain
Status: COMPLETED
Conditions: Neuralgia
Interventions: DRUG: Pregabalin (Lyrica)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacy-based Testing and Treatment for Gonorrhea and Chlamydia
Status: NOT_YET_RECRUITING
Conditions: Chlamydia Trachomatis Infection|Neisseria Gonorrheae Infection
Interventions: OTHER: Chlamydia trachomatis and Neisseria gonorrhea self-swab(s) and/or urine collection. Clinical assessment and prescribing of treatment for participants with positive test results
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: The Study of Long-term Outcomes of GR1802 in Patients With Chronic Rhinosinusitis With Nasal Polyps
Status: NOT_YET_RECRUITING
Conditions: Chronic Rhinosinusitis With Nasal Polyps
Interventions: DRUG: GR1802 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Septal Versus Apical Pacing- a Comparative Study Using Cardiac MRI
Status: COMPLETED
Conditions: Ventricular Dysfunction|Ventricular Remodelling
Interventions: PROCEDURE: Apical pacing|PROCEDURE: Septal pacing|DEVICE: Pacemaker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase II Trial of 18F-AV-45 Positron Emission Tomography (PET) Imaging in Healthy Volunteers, Patients With Mild Cognitive Impairment (MCI) and Patients With Alzheimer's Disease (AD)
Status: COMPLETED
Conditions: Alzheimer's Disease|Mild Cognitive Impairment
Interventions: DRUG: florbetapir F 18
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Doxorubicin Plus Olaratumab (LY3012207) in Participants With Advanced or Metastatic Soft Tissue Sarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: Olaratumab|DRUG: Doxorubicin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: This Study is to Assess the Efficacy of Difamilast Ointment in Mild to Moderate Atopic Dermatitis(AD)
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Difamilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Ferritin in Critically Ill Patients With Hemophagocytic Lymphohistiocytosis
Status: COMPLETED
Conditions: Hemophagocytic Lymphohistiocytosis (HLH)|Macrophage Activation Syndrome (MAS)|Hemophagocytic Syndromes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Erythropoietin (EPO) and Granulocyte-Colony Stimulating Factor (G-CSF) for Low-Risk Myelodysplastic Syndromes (MDS)
Status: UNKNOWN
Conditions: Myelodysplastic Syndromes
Interventions: BEHAVIORAL: Darbepoetin and Filgrastim|DRUG: Darbepoetin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 4Hz Transcranial Alternating Current Stimulation for Patients With Mild Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: DEVICE: transcranial alternating current stimulation|DEVICE: sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Health Literacy Tailored Communication
Status: COMPLETED
Conditions: Periodontal Diseases|Dental Plaque|Dental Calculus|Sialorrhea|Streptococcal Infections|Lactobacillus Infection
Interventions: BEHAVIORAL: Tailored oral health literacy instruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Dose-finding Study of SAR443122 in Adult Participants With Ulcerative Colitis
Status: RECRUITING
Conditions: Colitis Ulcerative
Interventions: DRUG: SAR443122|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine, Cisplatin, and Radiation Therapy Followed By Surgery or Surgery Alone in Treating Patients With Localized Pancreatic Cancer That Can Be Removed By Surgery
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: cisplatin|DRUG: gemcitabine hydrochloride|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Anti-Platelet Therapy With Pimecrolimus Drug Eluting Stent (RAPID)
Status: TERMINATED
Conditions: Coronary Disease
Interventions: DEVICE: Corio™ Pimecrolimus-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of CP-4055 in Patients With Refractory/Relapsed Hematologic Malignancies
Status: COMPLETED
Conditions: Hematologic Malignancies|AML
Interventions: DRUG: CP-4055|DRUG: CP-4055
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of "Lifespan Integration" (LI) Therapy in Patients With Complex Post-Traumatic Stress Disorder
Status: RECRUITING
Conditions: Post-Traumatic Stress Disorder Complex|Psychiatric Disorder|Abuse Neglect|Abuse Physical|Abuse, Sexual|Abuse Domestic|Abuse Verbal
Interventions: BEHAVIORAL: Lifespan Integration Therapy (LI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Researchers at UC San Diego Are Learning About the Benefits of Human Milk and How it Influences Infant and Child Health
Status: RECRUITING
Conditions: Breastfeeding|COVID-19 Infection|COVID-19 Vaccine|Remdesivir|Antibiotics
Interventions: BIOLOGICAL: COVID-19 Exposure|DRUG: Antibiotic
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Blood Brain Barrier Disruption (BBBD) Using MRgFUS in the Treatment of Her2-positive Breast Cancer Brain Metastases
Status: UNKNOWN
Conditions: Breast Cancer|Brain Metastases
Interventions: DEVICE: ExAblate BBBD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Study Comparing the Efficacy and Tolerability of Epinephrine and Norepinephrine in Cardiogenic Shock
Status: COMPLETED
Conditions: Cardiogenic Shock
Interventions: DRUG: epinephrine perfusion|DRUG: norepinephrine perfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BEARS Training Package to Maximise Hearing Abilities in Older Children and Teenagers With Bilateral Cochlear Implants
Status: NOT_YET_RECRUITING
Conditions: Hearing Loss, Sensorineural|Hearing Loss|Deafness|Hearing Impaired Children and Adolescents
Interventions: OTHER: Both EARS training package (BEARS)|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Denosumab and Osteoporotic Vertebral Compression Fracture
Status: COMPLETED
Conditions: Osteoporotic Vertebral Compression Fracture
Interventions: DRUG: Denosumab 60 mg/ml [Prolia]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of SGN-LIV1A in Breast Cancer Patients
Status: COMPLETED
Conditions: HER2 Positive Breast Neoplasms|Hormone Receptor Positive Breast Neoplasms|Triple Negative Breast Neoplasms|HER2 Mutations Breast Neoplasms
Interventions: DRUG: ladiratuzumab vedotin|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualized Medical Training and Calcipotriol and Betamethasone Dipropionate Gel in Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: PROCEDURE: Individualized practical training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Field Randomization of Nerinetide (NA-1) Therapy in Early Responders
Status: COMPLETED
Conditions: Acute Cerebral Ischemia
Interventions: DRUG: Nerinetide (NA-1)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Study of Ruzasvir and Bemnifosbuvir
Status: COMPLETED
Conditions: Healthy Volunteer Study
Interventions: DRUG: Cohort 1 BEM + Ruzasvir|DRUG: Cohort 2 Ruzasvir + BEM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PROphylaxis for ThromboEmbolism in Critical Care Trial (PROTECT)
Status: COMPLETED
Conditions: Critical Illness|Deep Venous Thrombosis
Interventions: DRUG: LMWH (Fragmin, dalteparin)|DRUG: Unfractionated Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Pegylated Liposomal Doxorubicin and Temsirolimus in Patients With Advanced Hepatocellular Cancer
Status: WITHDRAWN
Conditions: Liver Neoplasms
Interventions: DRUG: Temsirolimus 25mg and Pegylated liposomal doxorubicin 25mg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurobehavioral Substrates of Propranolol's Effects on Drug Cue Reactivity
Status: COMPLETED
Conditions: Cigarette Smoking
Interventions: DRUG: Propranolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Daratumumab
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Daratumumab|DRUG: Carfilzomib|DRUG: Dexamethasone|DRUG: Lenalidomide|DRUG: Pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Validation of a Risk Prediction Model for Venous Thromboembolism in Gynecological Cancer Patients Undergoing Systemic Antineoplastic Treatment: The Gynecological Cancer Associated Thrombosis (GynCAT) Study
Status: NOT_YET_RECRUITING
Conditions: Cancer-associated Thrombosis|Venous Thromboembolism|Gynecologic Cancer|Ovarian Cancer|Cervix Cancer|Endometrial Cancer|Vaginal Cancer
Interventions: DRUG: Anticoagulant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Engaging Men Through HIV Self-Testing With Differentiated Care to Improve ART Initiation and Viral Suppression Among Men in Malawi
Status: ACTIVE_NOT_RECRUITING
Conditions: Hiv
Interventions: OTHER: Home-Based ART|OTHER: Facility-Based ART
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 5-Fluoro-2'-Deoxycytidine and Tetrahydrouridine in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia|de Novo Myelodysplastic Syndromes|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndromes|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: 5-fluoro-2-deoxycytidine|DRUG: tetrahydrouridine|OTHER: laboratory biomarker analysis|GENETIC: reverse transcriptase-polymerase chain reaction|GENETIC: DNA methylation analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treating Insulin Resistance as a Strategy to Improve Outcome in Refractory Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Placebo|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First-In-Human Study to Evaluate the Safety, Tolerability, Immunogenicity, and Pharmacokinetics of LQ036
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: LQ036|OTHER: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of AD981 Versus Placebo in Obesity Hypoventilation Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity Hypoventilation Syndrome (OHS)
Interventions: DRUG: AD981|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT