pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Tolerability and Pharmacokinetics of Multiple Doses of SPH3127 in Chinese Healthy People
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: SPH3127 50mg|DRUG: SPH3127 100mg|DRUG: Placebo matching to SPH3127 50mg|DRUG: Placebo matching to SPH3127 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hepatic Artery Infusion (HAI) Program at Duke University
Status: WITHDRAWN
Conditions: Metastatic Colon Cancer|Liver Cancer|Intrahepatic Cholangiocarcinoma
Interventions: DEVICE: Medtronic Synchromed II pump
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kisspeptin Administration Subcutaneously to Patients With IHH
Status: RECRUITING
Conditions: Hypogonadotropic Hypogonadism
Interventions: DRUG: kisspeptin 112-121|DRUG: leuprolide acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Erythropoietin to Enhance Recovery of Erectile Function in Men Following Radical Prostatectomy
Status: COMPLETED
Conditions: Prostate Cancer|Erectile Dysfunction
Interventions: DRUG: Placebo|DRUG: Erythropoietin (EPO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating the Efficacy of CARBOPLATIN in Metastatic Prostate Cancer With Gene Alterations in the Homologous Recombination Pathway
Status: TERMINATED
Conditions: Castration-resistant Prostate Cancer|Metastasis
Interventions: DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose CdA Combined With Valproic Acid (VPA) in Previously Treated B-cell Chronic Lymphocytic Leukemia(B-CLL)
Status: UNKNOWN
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: valproic acid and 2-chlorodeoxyadenosine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ozone Therapy in Chemotherapy-induced Peripheral Neuropathy: RCT (O3NPIQ)
Status: RECRUITING
Conditions: Chemotherapy-induced Peripheral Neuropathy|Pain, Neuropathic|Pain Syndrome
Interventions: DRUG: Ozone|DRUG: Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Randomized, Double-Blind, Double-Dummy Comparative Trial of Azithromycin Sustained Release Versus 3-Day Azithromycin for the Treatment of Strep Throat in Adolescents and Adults
Status: COMPLETED
Conditions: Pharyngitis|Tonsillitis
Interventions: DRUG: azithromycin (Zithromax)|DRUG: placebo|DRUG: azithromycin SR|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Observational Study on the Safety Profile of MabThera/Rituxan (Rituximab) in Combination With Chemotherapy in Patients With B Cell-lineage Chronic Lymphocytic Leukaemia (MABERYC)
Status: COMPLETED
Conditions: Lymphocytic Leukemia, Chronic
Interventions: DRUG: Chemotherapy|DRUG: rituximab [MabThera/Rituxan]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of a Vaginally Administered Probiotic Lactobacilli Delivery System.
Status: COMPLETED
Conditions: Bacterial Vaginosis
Interventions: OTHER: Probiotic lactobacilli|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Radiographic Evaluation of The Labial Bone Dimensional Changes After Immediate Implant
Status: COMPLETED
Conditions: Immediate Implants|Esthetic Zone|Labial Bone Dimensional Changes|Without Labial Bone Grafting|With Labial Grafting|Thin Labial Plate of Bone Pre-extraction
Interventions: PROCEDURE: immediate implant placement without bone grafting|PROCEDURE: immediate implant placement with socket bone grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate AMG 162 in the Prevention of Postmenopausal Osteoporosis
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: AMG 162|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adjunctive Cilostazol Versus High Maintenance-dose Clopidogrel According to Cytochrome 2C19 Polymorphism
Status: COMPLETED
Conditions: Coronary Artery Disease|Percutaneous Coronary Intervention
Interventions: DRUG: cilostazol 100mg bid or clopidogrel 150-mg daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nitric Oxide Gas Inhalation in Severe Acute Respiratory Syndrome in COVID-19
Status: COMPLETED
Conditions: SARS (Severe Acute Respiratory Syndrome)|Coronavirus
Interventions: DRUG: Nitric Oxide Gas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neonatal Bacterial Colonization Study
Status: UNKNOWN
Conditions: Neonatal SEPSIS|Prematurity|Very Low Birth Weight Baby|Bloodstream Infection
Interventions: OTHER: Skin antisepsis|OTHER: Emollient
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ramosetron OD Tablet and Postdischarge Nausea and Vomiting
Status: UNKNOWN
Conditions: Day Surgery
Interventions: DRUG: Ramosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Modified-FLAI Induction and Consolidation Chemotherapy in Elderly Patient With Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: induction chemotherapy (fludarabine, cytarabine, idarubicin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Activated T Cells Armed With GD2 Bispecific Antibody in Children and Young Adults With Neuroblastoma and Osteosarcoma
Status: UNKNOWN
Conditions: Disseminated Neuroblastoma|Recurrent Neuroblastoma
Interventions: BIOLOGICAL: IL-2|BIOLOGICAL: GD2Bi-aATC|BIOLOGICAL: GM-CSF|OTHER: laboratory evaluations of immune responses
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ESBA1008 Safety, Tolerability and Effects in Wet Age-Related Macular Degeneration (AMD) Patients
Status: COMPLETED
Conditions: Exudative Age-Related Macular Degeneration
Interventions: BIOLOGICAL: ESBA1008 solution|BIOLOGICAL: Ranibizumab 0.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of DMOT4039A in Participants With Unresectable Pancreatic or Platinum-Resistant Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: DMOT4039A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Moderate to Severe Coronavirus Disease (COVID-19) in Hospitalized Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: DRUG: Baricitinib (janus kinase inhibitor)|DRUG: Remdesivir (antiviral) + barictinib (janus kinase inhibitor)|DRUG: Remdesivir (antiviral)|DRUG: Tocilizumab (interleukin 6 inhibitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a Novel H5N1 Influenza Vaccine in Healthy Adults Age 18-49 Years
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: VAX161 [STF2.HA5 H5N1]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Attenuating Ischemia Reperfusion Injury After Living Donor Renal Transplantation
Status: WITHDRAWN
Conditions: Kidney Transplantation|Renal Transplantation|Reperfusion Injury
Interventions: DRUG: Myfortic (mycophenolic acid)|DRUG: Myfortic (mycophenolic acid)|DRUG: Thymoglobulin (anti-thymocyte globulin)|DRUG: Thymoglobulin (anti-thymocyte globulin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms Underlying Peanut Allergic Reactions in TRACE Peanut Study Participants: Extension Study
Status: COMPLETED
Conditions: Food Hypersensitivity|Peanut Hypersensitivity
Interventions: OTHER: DBPCFC to peanut cookie|OTHER: Single-dose DBPCFC to peanut flour|OTHER: Single-dose DBPCFC to peanut butter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Postoperative Pain Management Following Robotic Assisted Sacrocolpopexy
Status: NOT_YET_RECRUITING
Conditions: Pelvic Organ Prolapse|Post Operative Pain
Interventions: PROCEDURE: Quadratus Lumborum (QL) Block|PROCEDURE: Enhanced Recovery After Surgical (ERAS) Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Carpal Tunnel Syndrome by Shearwave Elastography
Status: ENROLLING_BY_INVITATION
Conditions: Carpal Tunnel Syndrome
Interventions: DEVICE: FDA approved ultrasound system with shear wave elastography capability
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trans-cranial Direct Current Stimulation on Alcohol Craving
Status: RECRUITING
Conditions: Alcohol Dependence
Interventions: DEVICE: transCranial direct current stimulation|DEVICE: sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Cord Blood Mononuclear Cells (UCB-MNCs) in the Treatment of Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: normal saline|OTHER: Cord Blood Mononuclear Cells (UCB-MNCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Effect of Pregabalin on Postoperative Pain and Opioid Consumption in Spine Surgery
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Pregabalin 150mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I/II Study of Induction Chemotherapy With Daunorubicin, Cytarabine, Topotecan and Etoposide
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Cytarabine|DRUG: Daunorubicin|DRUG: Etoposide|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Educational Intervention to Increase the Emotional Competence of Patients With Oesogastric and Bronchopulmonary Cancers
Status: TERMINATED
Conditions: Digestive System Neoplasms|Thoracic Neoplasms
Interventions: BEHAVIORAL: Emotional skills|BEHAVIORAL: Relaxation and talking group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Envarsus XR® in Adolescent Renal Transplant Recipients
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Transplantation|Renal Transplantation|Grafting, Kidney
Interventions: DRUG: Envarsus XR|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-Surgical Management of Knee Osteoarthritis in the Military Health System (MHS)
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: BEHAVIORAL: DoD/VA CPG Core Set + PT|BEHAVIORAL: DoD/VA CPG Core Set
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dabigatran for Mitral Stenosis Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation|Mitral Stenosis
Interventions: DRUG: Dabigatran etexilate|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Elacestrant With/Without Triptorelin in Premenopausal Women With Luminal Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|HER2-negative Breast Cancer|Hormone Receptor Positive Tumor|Premenopausal Breast Cancer
Interventions: DRUG: Elacestrant|DRUG: Triptorelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: P-BCMA-101 Tscm CAR-T Cells in the Treatment of Patients With Multiple Myeloma (MM)
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: P-BCMA-101 CAR-T cells|DRUG: Rimiducid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Immunogenicity and Safety of 'IL-YANG Quadrivalent Influenza Vaccine Inj.'
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: IL-YANG Quadrivalent Influenza Vaccine|BIOLOGICAL: IL-YANG Flu Vaccine Prefilled Syringe|BIOLOGICAL: IL-YANG Trivalent Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Treatment of Tretinoin or Superficial Dermabrasion for Stretch Marks
Status: COMPLETED
Conditions: Stretch Marks|Striae|Treatment
Interventions: DRUG: Tretinoin cream 0.005%|DEVICE: Superficial Dermabrasion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ITIL-306 in Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Epithelial Ovarian Cancer|Non-small Cell Lung Cancer|Renal Cell Carcinoma
Interventions: BIOLOGICAL: ITIL-306
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alveolar Cleft Grafting Using Two Different Alloplastic Grafts
Status: UNKNOWN
Conditions: Alveolar Cleft Grafting
Interventions: DRUG: Puerarin|DRUG: β- tricalcium phosphate|DRUG: β- tricalcium phosphate alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Co-Administration of ABT-493 and ABT-530 With and Without RBV in Subjects With Chronic Hepatitis C Virus (HCV) Genotypes 2, 3, 4, 5 or 6 Infection
Status: COMPLETED
Conditions: Chronic Hepatitis C|Hepatitis C Virus
Interventions: DRUG: ABT-493|DRUG: ABT-530|DRUG: ribavirin (RBV)|DRUG: ABT-493/ABT-530
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin
Status: COMPLETED
Conditions: Coronary Disease
Interventions: DRUG: Endothelin-1|DRUG: BQ-123 and BQ-788
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Enteral Supplementation With Docosahexaenoic Acid and Arachidonic Acid (DHA-AA) in Preterm Infants
Status: RECRUITING
Conditions: Infant, Premature, Diseases
Interventions: DIETARY_SUPPLEMENT: DHA/AA emulsion supplement for preterm infant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CURATE.AI Optimized Modulation for Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: Cyclophosphamide|DRUG: Dexamethasone|OTHER: CURATE.AI-Guided dosage modulation|DRUG: Thalidomide|DRUG: Bortezomib|DRUG: Cyclophosphamide|DRUG: Thalidomide|DRUG: Dexamethasone|DRUG: Lenalidomide|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety of SPD489 When Added to Stable Doses of Antipsychotic Medications in Clinically Stable Adults With Negative Symptoms of Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: SPD489
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of Peptest™ for the Detection of Reflux in Cough
Status: COMPLETED
Conditions: Cough
Interventions: OTHER: Induction of cough with inhaled citric acid|PROCEDURE: Peptest™ analysis of saliva pepsin|DIAGNOSTIC_TEST: Peptest™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Chemotherapy in Treating Patients With Recurrent or Advanced Cancer of the Uterus
Status: TERMINATED
Conditions: Sarcoma
Interventions: DRUG: cisplatin|DRUG: doxorubicin hydrochloride|DRUG: mitomycin C
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effect of Probiotic Supplementation on the Mental Status, Inflammation, and Intestinal Barrier in Major Depressive Disorder Patients Using Gluten-free or Gluten-containing Diet
Status: UNKNOWN
Conditions: Depressive Disorder, Major|Depression
Interventions: COMBINATION_PRODUCT: Probiotic supplementation + gluten-free diet|COMBINATION_PRODUCT: Placebo supplementation + gluten-free diet|COMBINATION_PRODUCT: Probiotic supplementation + gluten-containing diet|COMBINATION_PRODUCT: Placebo supplementation + gluten-containing diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Corresponding Fixed-dose Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH)
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
Interventions: DRUG: FDC macitentan/tadalafil|DRUG: Macitentan 10 mg|DRUG: Tadalafil 40 mg|DRUG: Placebo FDC|DRUG: Placebo macitentan|DRUG: Placebo tadalafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Ovarian Reserve Concerning Patients With Multiple Sclerosis (MS), Compared to a Control Group
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: BIOLOGICAL: Anti-Mullerian hormone (AMH) level|OTHER: Antral follicle count (AFC)|OTHER: Clinical assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Celebrex and Metformin for Postoperative Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Liver Cancer
Interventions: DRUG: Celebrex plus Metformin|DRUG: Celebrex|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Safety, Tolerability and Pharmacokinetics of XC7 (Which is Planned Use in the Treatment of COVID-19) in Healthy Volunteers
Status: COMPLETED
Conditions: Covid19|Healthy Volunteers
Interventions: DRUG: XC7 100 mg single|DRUG: XC7 200 mg single|DRUG: Placebo single|DRUG: XC7 200 mg multiple|DRUG: Placebo multiple
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does Stellate Ganglion Block Decrease Stress Response of Intubation?
Status: UNKNOWN
Conditions: Intubation|Stellate Ganglion
Interventions: PROCEDURE: stellate block|DRUG: Na.Cl 0.9% (placebo)|DRUG: lidocaine 2%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of AZD0466 in Patients With Advanced Hematologic or Solid Tumors
Status: TERMINATED
Conditions: Advanced Solid Tumors|Lymphoma|Multiple Myeloma|Hematologic Malignancies
Interventions: DRUG: AZD0466
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Infusion of Norepinephrine vs Phenylephrine During Spinal Anesthesia for Cesarean Section (INPEACE)
Status: NOT_YET_RECRUITING
Conditions: Cesarean Section Complications|Hypotension
Interventions: DRUG: Continuous infusion of Norepinephrine|DRUG: Continuous infusion of Phenylephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Caffeine and Cocaine
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: Caffeine 150 MG|DRUG: Placebo|DRUG: Amphetamine|DRUG: Caffeine 300 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Circulating Tumor Cells in Lung Cancer Screening
Status: COMPLETED
Conditions: Lung Neoplasms|Pulmonary Disease, Chronic Obstructive
Interventions: BIOLOGICAL: Isolation of circulating tumor cells (CTC) from veinous blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease|Sarcopenia|Frailty
Interventions: DIETARY_SUPPLEMENT: CoQ10|DIETARY_SUPPLEMENT: Nicotinamide riboside|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Occupational Therapy on the Function and Mobility of Elbow Fractures
Status: COMPLETED
Conditions: Supracondylar Humerus Fracture
Interventions: OTHER: Occupational therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blinatumomab in Adult Patients With Minimal Residual Disease (MRD) of B-precursor Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: ALL, Recurrent, Adult
Interventions: DRUG: Blinatumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postural Sway and Counterpressure Maneuvers for Pediatric Syncope
Status: RECRUITING
Conditions: Syncope, Vasovagal|Postural Orthostatic Tachycardia Syndrome|Orthostatic Intolerance
Interventions: BEHAVIORAL: Counterpressure Maneuvers|BEHAVIORAL: Baseline Stand
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study of Folate Receptor-Mediated Staining Solution (FRD™) In Cervical Lesion Detection
Status: UNKNOWN
Conditions: Cervical Intraepithelial Neoplasia Grade 2/3
Interventions: COMBINATION_PRODUCT: FRD|OTHER: Cytology|OTHER: HPV testing|PROCEDURE: Colposcopy|PROCEDURE: ECC|PROCEDURE: Biospy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Compressive Myofascial Release in Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: OTHER: compressive myofascial release|OTHER: conventional treatment group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Synergic Effects of Ultrasound and Laser on the Pain Relief and Functionality
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: Ultrasound plus Laser and therapeutic exercise|DEVICE: Ultrasound plus Laser|DEVICE: Utrasound plus Laser Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paradigm Shift in Medical Education: Applications of High-Fidelity Simulation, Teamwork Model Development, and Concept of Flipped Classroom in Innovation and Revolution of Resuscitation Training
Status: COMPLETED
Conditions: Skill Acquisition of Resuscitation
Interventions: OTHER: high-fidelity simulation and teamwork training|OTHER: traditional resuscitation training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: X-396 Capsule in Patients With ALK-positive Non-small Cell Lung Cancer Previously Treated With Crizotinib
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: X-396 capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy and Ixabepilone in Treating Patients With High-Risk Stage III Prostate Cancer After Surgery
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: DRUG: ixabepilone|PROCEDURE: adjuvant therapy|RADIATION: intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotics on Oral Homeostasis During Sugar Stress
Status: COMPLETED
Conditions: Dental Caries|Probiotics|Gingivitis
Interventions: BEHAVIORAL: Sugar stress
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intravenous Immunoglobulin and Plasma Exchange in Myasthenia Gravis
Status: COMPLETED
Conditions: Myasthenia Gravid
Interventions: BIOLOGICAL: IVIG|PROCEDURE: PLEX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The SOAR (Stop OsteoARthritis) Program Proof-of-Concept Study
Status: COMPLETED
Conditions: Arthritis|Osteoarthritis|Arthritis Knee|Osteo Arthritis Knee|Knee Injuries|Anterior Cruciate Ligament Tear|Meniscus Tear
Interventions: BEHAVIORAL: Immediate 8-Week SOAR Program|BEHAVIORAL: Delayed 8-Week SOAR Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fibular Fixation in Ankle Fractures:Plate Verses Nail.
Status: COMPLETED
Conditions: Distal Fibula Fracture
Interventions: PROCEDURE: Open reduction internal fixation|PROCEDURE: Intermedullary Nail
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy With GEN0101 and Pembrolizmub in Advanced Melanoma Patients PIb/PII
Status: UNKNOWN
Conditions: Advanced Melanoma
Interventions: DRUG: Combination of GEN0101 and Pembrolizmub
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Cerebral Hemodynamic and Cognitive Effects of Acute Resveratrol Administration in Young, Healthy Adults at Stimulated Altitude.
Status: COMPLETED
Conditions: Hypoxia, Altitude|Brain
Interventions: DIETARY_SUPPLEMENT: Resveratrol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Clinical Trial Investigating Efficacy of EFT (Emotional Freedom Technique) for Food Cravings
Status: COMPLETED
Conditions: Food Cravings
Interventions: BEHAVIORAL: EFT - the Emotional Freedom technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial Evaluating the Efficacy of a Skin Cream in Improving Facial Appearance and Skin Elasticity
Status: UNKNOWN
Conditions: Atrophy, Hemifacial|Elastosis|Photoaging
Interventions: OTHER: Adipeau face cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Bolus Recombinant Nonimmunogenic Staphylokinase (Fortelyzin) and Bolus Infusion Alteplase in Patients With AIS
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: Recombinant staphylokinase|DRUG: Alteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Leveraging Parents and Peers to Increase Recovery Capital in Emerging Adults
Status: RECRUITING
Conditions: Polysubstance Drug Use (Indiscriminate Drug Use)
Interventions: BEHAVIORAL: Contingency Management for Emerging Adults (CM-EA)|BEHAVIORAL: Standard Peer Recovery Support Services (PRSS) +Vocational/Educational (V/E) Skill Building services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Minimal Islet Transplant at Diabetes Onset
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: BIOLOGICAL: Human pancreatic islet|DRUG: ATG|DRUG: Pegylated G-CSF|DRUG: Rapamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Speed of Recovery of Reversal of Neuromuscular Blockade in Geriatric Patients Undergoing Spine Surgery
Status: COMPLETED
Conditions: Spine Surgery
Interventions: DRUG: sugammadex|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-label, Multiple Ascending Dose Study of Ravulizumab (ALXN1210) in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)
Status: COMPLETED
Conditions: Paroxysmal Nocturnal Hemoglobinuria|PNH
Interventions: BIOLOGICAL: Ravulizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Catheter Ablation on Burden of Atrial Fibrillation (MRICEMAN)
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Immunological Long-term Follow-up of Patients With Pemphigus Included in the "RITUXIMAB 3" Trial
Status: UNKNOWN
Conditions: Autoimmune Diseases
Interventions: DRUG: Rituximab|DRUG: corticosteroids'therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contraceptives Containing Drospirenone and Blood Pressure
Status: COMPLETED
Conditions: Blood Pressure|Contraception
Interventions: DRUG: 30EE+DRSP|DRUG: 20EE+DRSP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Intraoperative Dexmedetomidine Infusion in Endovascular Intervention for Aneurysmal Subarachnoid Hemorrhage
Status: RECRUITING
Conditions: Dexmedetomidine|Infusion|Endovascular|Aneurysmal Subarachnoid Hemorrhage
Interventions: DRUG: Intraoperative Dexmedetomidine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Can Acetaminophen Given 1-2 Hours to Children Before Ear Tube Surgery Reduce Agitation After Anesthesia?
Status: TERMINATED
Conditions: Emergence Agitation|Pain
Interventions: DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Compare Safety and Efficacy of Doripenem Versus Imipenem-Cilastatin in Patients With Ventilator-Associated Pneumonia
Status: TERMINATED
Conditions: Ventilator-Associated Pneumonia
Interventions: DRUG: Doripenem|DRUG: Imipenem-Cilastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MUltimodal Targeted Axillary Surgery
Status: UNKNOWN
Conditions: Node-positive Breast Cancer
Interventions: DIAGNOSTIC_TEST: Systematic axillary ultrasound imaging|DIAGNOSTIC_TEST: Sentinel node|PROCEDURE: Excision of suspicious lymph nodes|PROCEDURE: Two steps axillary node clearance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Synergizing Home Health Rehabilitation Therapy
Status: ENROLLING_BY_INVITATION
Conditions: Frailty|Frail Elderly|Occupational Therapy|Activities of Daily Living|Home Health Care|Functional Status|Physical Functional Performance|Rehabilitation|Treatment Outcome|Health Services for the Aged
Interventions: OTHER: ADL-enhanced program|OTHER: Usual home health rehabilitation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Stabilization Exercises After Radiofrequency Lumbar Facet Denervation
Status: COMPLETED
Conditions: Low Back Pain|Facet Joint Pain|Radiofrequency Denervation|Pain|Disability Physical
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of SCAI of Bevacizumab Combined With IC of Tislelizumab in the Treatment of Recurrent Glioblastoma.
Status: NOT_YET_RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: Tislelizumab and Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Subretinal OPGx-001 for LCA5-Associated Inherited Retinal Degeneration (LCA5-IRD)
Status: RECRUITING
Conditions: LCA5
Interventions: BIOLOGICAL: AAV8.hLCA5
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine/Capecitabine Followed by SBRT in Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Capecitabine|RADIATION: Stereotactic Body Radiation Therapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sacituzumab Govitecan in Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Sacituzumab Govitecan (SG)|DRUG: Physicians Choice (PhC).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel and Radiation Therapy Plus Chemoprotection With Amifostine in Treating Patients With Stage III or Stage IV Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer|Oral Complications
Interventions: DRUG: amifostine trihydrate|DRUG: paclitaxel|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modified TBF Regimen as Conditioning Regimen Prior to Allo-HSCT for T-ALL/LBL
Status: RECRUITING
Conditions: Cytarabine+Thiotepa + Fludarabine + Busulfan|T Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Interventions: DRUG: cytarabine+thiotepa+ fludarabine + busulfan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Utilizing Holmium Laser for FURS Renal Stone Lithotripsy Comparing Stone Breaking vs. Stone Dusting Settings
Status: TERMINATED
Conditions: Stone Clearance
Interventions: DEVICE: Lumenis Pulse 120H holmium laser system and 200 DFL ball tip fiber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CM Asia Nail With AS2 Without AS2 （AS2 Study）
Status: COMPLETED
Conditions: Trochanteric Fracture of Femur
Interventions: PROCEDURE: Open Reduction and Internal Fixation|DEVICE: ZNN CM Asia|DEVICE: Anterior Support Screw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Injectable Platelet Rich Fibrin in Lichen Planus
Status: COMPLETED
Conditions: Lichen Planus
Interventions: OTHER: Platelet Rich Fibrin Injection|DRUG: Corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Developing and Testing AI Models for Fetal Biometry and Amniotic Volume Assessment in Fetal Ultrasound Scans.
Status: COMPLETED
Conditions: Small for Gestational Age Infant|Fetal Growth Restriction|Oligohydramnios|Polyhydramnios
Interventions: DIAGNOSTIC_TEST: Classification and segmentation deep learning models
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vacuum Suspension: Effects on Tissue Oxygenation, Activity and Fit
Status: COMPLETED
Conditions: Amputation|Diabetes|Leg Injuries|Traumatic Amputations
Interventions: DEVICE: Total Surface Bearing Suction Socket|DEVICE: Vacuum assisted socket system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Combination With Rintatolimod and/or Sargramostim in Treating Patients With Stage II-IV HER2-Positive Breast Cancer
Status: COMPLETED
Conditions: HER2-positive Breast Cancer|Male Breast Cancer|Recurrent Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer
Interventions: BIOLOGICAL: HER-2/neu peptide vaccine|BIOLOGICAL: sargramostim|DRUG: rintatolimod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ROSA Total Knee Post Market Study EMEA
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Pain|Chronic Osteoarthritis|Avascular Necrosis of the Femoral Condyle|Moderate Varus, Valgus or Flexion Deformities|Rheumatoid Arthritis
Interventions: PROCEDURE: Device: Persona Total Knee|PROCEDURE: Device: NexGen Total Knee|PROCEDURE: Device: Vanguard Total Knee
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aromatherapy Applied to Intensive Care Nurses Effect on Fatigue and Sleep Quality
Status: RECRUITING
Conditions: Aromatherapy
Interventions: OTHER: Aromatherapy Intervention Group-1|OTHER: Aromatherapy Intervention Group-2|OTHER: Aromatherapy Placebo Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Long-Term Extension Study of WA22762 to Evaluate Safety and Efficacy of Subcutaneous Tocilizumab in Participants With Moderate to Severe Rheumatoid Arthritis (RA).
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Mindfulness-based Intervention in Stress, Pain and Quality of Life in People Undergoing Hemodialysis
Status: COMPLETED
Conditions: Renal Insufficiency, Chronic|Kidney Failure, Chronic|Kidney Diseases|Kidney Insufficiency, Chronic|Chronic Kidney Diseases|End-Stage Kidney Disease
Interventions: BEHAVIORAL: Mindfulness-based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correction of Myopia Evaluation Trial 2
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Progressive Addition Lenses (PALs)|DEVICE: Single Vision Lenses (SVLs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Snack Study: The Feasibility of Changing Night-time Food Choices to Improve Glucose Tolerance in Pregnancy
Status: COMPLETED
Conditions: Glucose Intolerance|Obesity
Interventions: BEHAVIORAL: Low glycemic load snacks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Low-Dose Naltrexone and Acetaminophen Combination in the Treatment of Chronic Low Back Pain (ANODYNE-4)
Status: COMPLETED
Conditions: Chronic Low Back Pain|Lumbar Radiculopathy
Interventions: DRUG: Low-dose naltrexone and acetaminophen combination|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Study of the Safety and Pharmacokinetics of Intravenously Infused Berubicin in Pediatric Patients With Progressive, Refractory, or Recurrent High Grade Gliomas
Status: WITHDRAWN
Conditions: High Grade Glioma
Interventions: DRUG: Berubicin Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MSCs in COVID-19 ARDS
Status: TERMINATED
Conditions: Mesenchymal Stromal Cells|Remestemcel-L|Acute Respiratory Distress Syndrome|COVID
Interventions: BIOLOGICAL: Remestemcel-L|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reversal of the Neurological Deficit in Acute Stroke With the Signal of Efficacy Trial of Auto BPAP to Limit Damage From Suspected Sleep Apnea
Status: UNKNOWN
Conditions: Ischemic Stroke
Interventions: DEVICE: Non-invasive ventilatory treatment with auto-BPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XLPE High Flex Tibial Inserts
Status: ACTIVE_NOT_RECRUITING
Conditions: Total Knee Arthroplasty
Interventions: DEVICE: Legion™ CR Oxinium and CoCr Femoral Implants combined with Legion™/Genesis™ II XLPE High Flex Tibial Inserts
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The SIR-POBA Bypass Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Peripheral Arterial Occlusive Disease|Bypass Complication|Femoropopliteal Artery Occlusion|Femoropopliteal Stenosis|Critical Limb-Threatening Ischemia|Claudication, Intermittent
Interventions: PROCEDURE: Balloon Angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oropharyngeal Administration of Colostrum to Extremely Low Gestational Age Newborns
Status: COMPLETED
Conditions: Extremely Low Gestational Age Newborn|Premature Infant
Interventions: OTHER: oropharyngeal administration of own mother's colostrum|OTHER: oropharyngeal administration of sterile water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Resistance Sprint Training With and Without Power Training on Sprint and Agility Performance
Status: COMPLETED
Conditions: Resistance Sprint Training With and Without Power
Interventions: OTHER: with baseline intervention and power training interventions|OTHER: baseline interventions and without power training interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture vs Sham Acupuncture for Hand Osteoarthritis
Status: RECRUITING
Conditions: Hand Osteoarthritis
Interventions: PROCEDURE: Acupuncture|PROCEDURE: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin C, Hydrocortisone and Thiamine for Septic Shock
Status: RECRUITING
Conditions: Shock, Septic
Interventions: DRUG: Combined Vitamin C and Stress-Dose Hydrocortisone|DRUG: Placebo plus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT