pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Bioequivalence Study of Two Treatments in the Treatment of Inflammatory Lesions of Rosacea on the Face
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: Azelaic acid foam|DRUG: Azelaic acid foam|DRUG: Azelaic acid foam - Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Renal Actions of Combined Empagliflozin and LINagliptin in Type 2 diabetES
Status: UNKNOWN
Conditions: Type2 Diabetes
Interventions: DRUG: EMPA/LINA 10/5 mg QD (n=22)|DRUG: LINA/EMPA 5/10 mg QD (N=22)|DRUG: Gliclazide 30 mg QD/BID (N=22)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin A and Azithromycin for Acne Vulgaris
Status: UNKNOWN
Conditions: Acne Vulgaris
Interventions: DRUG: Vitamin A|DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Fidaxomicin in Healthy Male Japanese and Caucasian Subjects
Status: COMPLETED
Conditions: Pharmacokinetics of Fidaxomicin|Healthy Subjects
Interventions: DRUG: Fidaxomicin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Inflammation Control For Elders: ICE Study
Status: WITHDRAWN
Conditions: Inflammation|Aging
Interventions: DRUG: Methotrexate + Folic Acid|DRUG: Placebo + Folic Acid|PROCEDURE: Functional MRI Experimental Tasks|PROCEDURE: Muscle Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Application of a Novel Allergen-Specific Immune Signature Directed Approach to Dietary Elimination Therapy in Patients With Eosinophilic Esophagitis (IDiET)
Status: COMPLETED
Conditions: Eosinophilic Esophagitis
Interventions: DEVICE: Novel Allergen-Specific Immune Signature Directed Approach to Dietary Elimination Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MH004 Topical Cream in Healthy Adult Volunteers and Participants With Atopic Dermatitis or Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Atopic Dermatitis|Rheumatoid Arthritis
Interventions: DRUG: MH004 Ia(0.1%)|DRUG: MH004 Ia(0.3%)|DRUG: MH004 Ia(1%)|DRUG: MH004 Ia(3%)|DRUG: MH004 Ib-1(0.1%)|DRUG: MH004 Ib-1(0.3%)|DRUG: MH004 Ib-1(1%)|DRUG: MH004 Ib-2(0.3%)|DRUG: MH004 Ib-2(1%)|DRUG: MH004 Ib-2(3%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Fentanyl
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Fentanyl|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation the Safety and Efficacy of Cilostazol in Treatment of Patients With Fatty Liver Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Fatty Liver, Nonalcoholic
Interventions: DRUG: Cilostazol 50 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Integrating the Use of Calibration-Free Continuous Monitoring for Pregnancy Glucose Profiling: I-Profile Study
Status: RECRUITING
Conditions: Gestational Diabetes|Pregnancy
Interventions: DEVICE: Blinded Group|DEVICE: Unblinded group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Linperlisib Combined With Chidamide in Patients With PTCL
Status: RECRUITING
Conditions: Peripheral T-cell Lymphoma
Interventions: DRUG: Linperlisib and chidamide|DRUG: cyclophosphamide, doxorubicin/epirubicin, vincristine, and prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized and Open Label Study for Safety and Efficacy of DBI-102 vs. Vehicle vs. Hydroquinone on Skin Pigmentation and Lentigos
Status: COMPLETED
Conditions: Hyperpigmentation
Interventions: DRUG: DBI-102|DRUG: Vehicle gel|DRUG: Hydroquinone Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Local Anesthetic Treatments for Overactive Bladder
Status: TERMINATED
Conditions: Overactive Bladder
Interventions: DRUG: alkalinized xylocaine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dual BET and CBP/p300 Inhibitor in Patients With Targeted Advanced Solid Tumors
Status: RECRUITING
Conditions: Castrate Resistant Prostate Cancer|NUT Carcinoma
Interventions: DRUG: EP31670
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epirubicin Plus Irinotecan in Treating Patients With Advanced Cancer
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: epirubicin hydrochloride|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Management of Combined Fracture Neck of Femur and Femoral Deformity in Osteogenesis Imperfecta Patient
Status: RECRUITING
Conditions: Osteogenesis Imperfecta
Interventions: PROCEDURE: corrective osteotomy and intramedullary telescoping nail for deformed femur and Wagner technique to fix NOF fracture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of INV-202 in Patients With Diabetic Kidney Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetic Kidney Disease
Interventions: DRUG: INV-202|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Single Center Pilot Study Using the ECGenius System to Collect Electrogram Data to Test an Ablation Impact Algorithm
Status: ACTIVE_NOT_RECRUITING
Conditions: Persistent Atrial Fibrillation|Cardiac Arrhythmia
Interventions: PROCEDURE: Cardiac Ablation for the treatment of persistent Atrial Fibrillation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Perioperative Lidocaine and Ketamine in Abdominal Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Postoperative Pain
Interventions: DRUG: Lidocaine and ketamine|DRUG: Lidocaine|DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-Guided Erector Spinae Plane Block Following Arthroscopic Shoulder Surgery
Status: COMPLETED
Conditions: Shoulder Syndrome
Interventions: OTHER: Erector spinae plane block (Group E)|OTHER: Sham block group (Group S)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assess 123-I IMPY and SPECT Imaging as a Tool to Detect β-Amyloid in the Brain
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: [123I] IMPY & SPECT Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dynamic 68Ga-PSMA and 18F-FDG PET/CT Analysis Prior to 177Lu-PSMA
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer Metastatic
Interventions: OTHER: Parametric acquisition
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Hepassocin Levels in Patients With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Hepassocin (Hepatocyte-derived Fibrinogen-related Protein 1)|Polycystic Ovary Syndrome|Obesity|Insulin Resistance
Interventions: OTHER: hepassocin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Conditional Imaging Prescription Strategy for Exploration of Acute Uncomplicated Renal Colic
Status: COMPLETED
Conditions: Acute Renal Colic|Nephrolithiasis
Interventions: DEVICE: Diagnostic imaging modalities for suspected renal colic
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Prevalence of Appendiceal Tumours in Periappendicular Abscess
Status: NOT_YET_RECRUITING
Conditions: Appendix Abscess|Appendicitis|Appendix Mass|Appendix Cancer|Appendix Nec|Appendix Tumor|Appendix Diseases
Interventions: PROCEDURE: Interval appendectomy|DIAGNOSTIC_TEST: Follow-up MRI at 1 year
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lurbinectedin or in Combination With Irinotecan Versus Topotecan in Patients With Relapsed SCLC
Status: NOT_YET_RECRUITING
Conditions: Relapsed Small Cell Lung Cancer
Interventions: DRUG: Lurbinectedin|DRUG: Irinotecan|DRUG: Lurbinectedin|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stress Echocardiography and Heart Computed Tomography (CT) Scan in Emergency Department Patients With Chest Pain
Status: COMPLETED
Conditions: Chest Pain|Angina|Angina Pectoris|Coronary Artery Disease
Interventions: PROCEDURE: Stress Echocardiography|PROCEDURE: Coronary CT Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Feasibility Study for Women Receiving Anthracycline Chemotherapy With or Without Radiation for HER2-neu Positive Invasive Ductal Carcinoma
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: OTHER: Feasibility study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Prospective, Multicenter, Randomized Controlled Trial to Evaluate the Efficacy and Safety of the Transcatheter Tricuspid Valvuloplasty System in Patients With Severe or Above Tricuspid Regurgitation
Status: NOT_YET_RECRUITING
Conditions: Tricuspid Regurgitation
Interventions: DEVICE: Transcatheter Annuloplasty|OTHER: The guidelines guide medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficiency of γδ T Cell Against Non Small Lung Cancer ( Without EGFR Mutation)
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: DC-CIK|BIOLOGICAL: γδ T Cell|BIOLOGICAL: γδ T/DC-CIK cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: No DIET Trial: Dogmatic Interruption of Enteral nuTrition
Status: RECRUITING
Conditions: Gastrostomy|Tracheostomy
Interventions: OTHER: Nutrition will not be stopped preoperatively, but in the operating room (OR) for scheduled procedure.|OTHER: Nutrition will be stopped when the patient is called to the OR for scheduled procedure.|OTHER: Nutrition will be stopped 4 hours before the scheduled procedure.|OTHER: Nutrition will be stopped 6 hours before the scheduled procedure.|OTHER: Nutrition will be stopped 8 hours before the scheduled procedure.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Effects of Two Doses of MBX-8025 in Subjects With Primary Biliary Cirrhosis (PBC)
Status: TERMINATED
Conditions: Primary Biliary Cirrhosis (PBC)
Interventions: DRUG: Placebo Comparator|DRUG: Experimental: Seladelpar / MBX-8025 50 mg|DRUG: Experimental: Seladelpar / MBX-8025 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Building Family Caregiver Skills Using a Simulation-Based Intervention for Care of Cancer Patients
Status: RECRUITING
Conditions: Cancer
Interventions: BEHAVIORAL: One-on-one teaching sessions|BEHAVIORAL: Telephone booster contact
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Use of Oral Steroids in the Treatment of Cellulitis
Status: WITHDRAWN
Conditions: Cellulitis|Erysipelas
Interventions: DRUG: Prednisone|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "The Effects of Caffeine on Overactive Bladder Symptoms and Mental Health in Postmenopausal Women"
Status: COMPLETED
Conditions: Overactive Bladder|Caffeine|Menopause
Interventions: DIETARY_SUPPLEMENT: 400 mg of caffeine/day (Two 200mg pills/day)|DIETARY_SUPPLEMENT: 200 mg of caffeine/day (One 200mg pill and one placebo pill)|DIETARY_SUPPLEMENT: Two placebo pills/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Role of rhPSMA-7.3 PET/CT Imaging in Men With High-Risk Prostate Cancer Following Conventional Imaging and Associated Changes in Medical Management
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: rhPSMA-7.3 (18F)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Development of a Family-Based Transition Planning Program for Culturally-Diverse Youth on the Autism Spectrum
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism Spectrum Disorder|Family Relations
Interventions: BEHAVIORAL: Families FORWARD (Focusing on Relationships, Well-being, and Responsibility aheaD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: High VS Low Flow Nasal O2 for Acute Hypercapnic Respiratory Failure
Status: UNKNOWN
Conditions: Acute Hypercapnic Respiratory Failure|Acute Exacerbation of COPD
Interventions: DEVICE: High flow nasal therapy|DEVICE: Low flow oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Evacetrapib (LY2484595) in Combination With Atorvastatin in Japanese Participants With Primary Hypercholesterolemia
Status: TERMINATED
Conditions: Hypercholesterolemia
Interventions: DRUG: Evacetrapib|DRUG: Ezetimibe|DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Cell Sheets Transplantation After ESD in the Esophagus
Status: COMPLETED
Conditions: Barrett Esophagus
Interventions: PROCEDURE: ESD/EMR plus Cell Sheet|PROCEDURE: ESD/EMR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Triple-dose Tuberculosis Retreatment Regimens: How to Overcome Resistance Without Creating More
Status: WITHDRAWN
Conditions: Tuberculosis, Pulmonary
Interventions: DRUG: 6EH³RZ|DRUG: 6EHR³Z|DRUG: 6EHRZLfx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expanded Access Use of DKN-01 for the Treatment of Advanced Solid Tumors
Status: AVAILABLE
Conditions: Esophageal Neoplasm|Adenocarcinoma of the Gastroesophageal Junction|GastroEsophageal Cancer|Squamous Cell Carcinoma|Gastric Adenocarcinoma|Endometrial Cancer|Uterine Cancer|Ovarian Cancer|Carcinosarcoma|Gastric Cancer
Interventions: DRUG: DKN-01
Study Type: EXPANDED_ACCESS
Clinical trial: A Pharmacokinetic stuDy of intRavitreal Aflibercept Injection in Vitrectomized and Non-vitrectomized Eyes With Diabetic Macular Edema
Status: WITHDRAWN
Conditions: Diabetic Macular Edema
Interventions: DRUG: Intravitreal Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Injection Site Pain Experience for Semaglutide and Dulaglutide sc
Status: COMPLETED
Conditions: Healthy Volunteers|Diabetes Mellitus, Type 2|Overweight|Obesity
Interventions: DRUG: Semaglutide|DRUG: Dulaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: L-Menthol Injection as a Novel Technique During Colonoscopy
Status: TERMINATED
Conditions: Colonic Polyps|Colon Cancer
Interventions: DRUG: Peppermint Oil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Treatment Failure of Chlamydial Infection in Males and Females in Youth Correctional Facilities
Status: COMPLETED
Conditions: Chlamydial Infection
Interventions: DRUG: Azithromycin|DRUG: Doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Operative Versus Non-operative Treatment of Achilles Tendon Rupture
Status: COMPLETED
Conditions: Achilles Tendon Rupture
Interventions: PROCEDURE: Surgical repair Achilles tendon rupture|PROCEDURE: Non-surgical repair Achilles tendon rupture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Fidaxomicin Versus Placebo for Prophylaxis Against Clostridium Difficile-Associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation (MK-5119-001)
Status: COMPLETED
Conditions: Clostridium Difficile-Associated Diarrhea (CDAD)
Interventions: DRUG: fidaxomicin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Short Versus Long-term Levetiracetam in Brain Tumors
Status: RECRUITING
Conditions: Seizures|Brain Tumors|Antiepileptics|Levetiracetam
Interventions: DRUG: Levetiracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Two Insulin Aspart Formulations (100 U/mL Versus 200 U/mL)
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Low-dose vs. Normal-dose Psychostimulants on Executive Functions in Individuals With ADHD
Status: ACTIVE_NOT_RECRUITING
Conditions: Attention Deficit Hyperactivity Disorders
Interventions: DRUG: Psychostimulants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Protein Hydrolysate Supplement on Systemic Muscle Function Markers Following Resistance Type Exercise in Male Subjects
Status: COMPLETED
Conditions: Muscle Injury
Interventions: DIETARY_SUPPLEMENT: Elio|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Immunogenicity and Safety of the Vaccination of Human Papillomavirus Vaccine and Measles-Mumps-Rubella Vaccine
Status: UNKNOWN
Conditions: Human Papilloma Virus Infection Type 16|Human Papilloma Virus Infection Type 18|Measles|Rubella|Mumps
Interventions: BIOLOGICAL: HPV+MMR（0d），HPV（6m）|BIOLOGICAL: HPV（0d），HPV（6m），MMR（7m）|BIOLOGICAL: MMR（0d），HPV（1m），HPV（7m）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Safety and Efficacy of the Buprenorphine Transdermal Delivery System in Subjects With Osteoarthritis Pain.
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Buprenorphine transdermal delivery system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Delorme Resistance Exercises Versus Treadmill Training in Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: Treadmill training|OTHER: traditional physical therapy|OTHER: Delorme resistance exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: McGrath Videolaryngoscopy and Direct Laryngoscopy in Morbidly Obese Patients
Status: COMPLETED
Conditions: Morbid Obesity
Interventions: DEVICE: McGrath videolaryngoscopy|DEVICE: Direct laryngoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Open Label Study That Will Test Safety and Efficacy of RZL-012 Injection Into the Submental Fat in Chinese vs. Non-Chinese Subjects.
Status: COMPLETED
Conditions: Submental Fat
Interventions: DRUG: RZL-012
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY2409021 in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: LY2409021|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evidence of pH Dependent ß2 Adrenergic Transport Mechanisms in the Airway
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: quiet breathing|OTHER: Hypocapnic Hyperventilation|OTHER: Hypercapnic Hyperventilation|OTHER: eucapnic hyperventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bioimaging Study of 89Zr-M7824 in NSCLC
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer
Interventions: COMBINATION_PRODUCT: 89Zirconium-M7824|DRUG: M7824
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Liraglutide in Obese Children Aged 7 to 11 Years
Status: COMPLETED
Conditions: Metabolism and Nutrition Disorder|Obesity
Interventions: DRUG: liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NKG2D CAR-T Cells to Treat Patients With Previously Treated Liver Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Refractory Metastatic Colorectal Cancer
Interventions: BIOLOGICAL: CAR-T infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Curcumin and Exercise in Chronic Kidney Disease
Status: WITHDRAWN
Conditions: Chronic Kidney Diseases|Blood Pressure|Hyperemia|Vasoconstriction
Interventions: DRUG: Curcumin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telmisartan Promotes the Differentiation of Monocytes Into Macrophages M2 in Diabetic Nephropathy?
Status: COMPLETED
Conditions: Diabetic Nephropathy
Interventions: DRUG: telmisartan during 6 months|DRUG: Losartan during 6 months|PROCEDURE: blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: CPT and Smoking Cessation
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic|Smoking
Interventions: BEHAVIORAL: Cognitive Processing Therapy (CPT)|DRUG: Bupropion|DRUG: nicotine replacement therapy (NRT)|BEHAVIORAL: Integrated Care for Smoking Cessation (ICSC)|BEHAVIORAL: smokefreeVET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability of Ambien (Zolpidem) in the Treatment of Children Ages 6 to 17 With Attention Deficit Hyperactivity Disorder (ADHD)-Associated Insomnia
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Zolpidem (SL800750)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multiparametric MRI in Evaluating Cancer Stage and Helping Treatment Planning in Patients With Prostate Cancer
Status: RECRUITING
Conditions: Prostate Carcinoma
Interventions: DIAGNOSTIC_TEST: Multiparametric Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Carbohydrates to Prevent Hypoglycaemia During Physical Activity in Patients With Type 1 Diabetes
Status: COMPLETED
Conditions: Hypoglycaemia
Interventions: OTHER: low amount of carbohydrates|OTHER: high amount of carbohydrates|OTHER: Rapid-acting carbohydrates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Triticum Aestivum vs Placebo on Metabolic Profile Components and Insulin Sensitivity in Patients With Obesity
Status: RECRUITING
Conditions: Obesity|Drug Effect|Insulin Sensitivity
Interventions: DRUG: Triticum Aestivum|DRUG: Placebo (calcined magnesia)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Modification of ESIN-osteosynthesis in a Femoral Fracture Model and Its Transmission to Clinical Practice
Status: COMPLETED
Conditions: Femoral Fracture|Children
Interventions: PROCEDURE: 3-Nail-ESIN in femoral shaft fractures
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Third Ventriculostomy vs. Ventriculoperitoneal Shunt in Idiopathic Normal Pressure Hydrocephalus (ENDOVEST)
Status: NOT_YET_RECRUITING
Conditions: Idiopathic Normal Pressure Hydrocephalus (INPH)
Interventions: PROCEDURE: Endoscopic third ventriculostomy (ETV)|PROCEDURE: Ventriculoperitoneal shunt (VPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiotherapy in the Reduction of Post-needling Soreness
Status: COMPLETED
Conditions: Dry Needling|Soreness, Muscle|Trigger Point Pain, Myofascial
Interventions: OTHER: Concentric contraction exercise|OTHER: Isometric contraction exercise|OTHER: Eccentric contraction exercise|OTHER: Analytic passive stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stromal TARgeting for PAncreatic Cancer (STAR_PAC)
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma
Interventions: DRUG: ATRA|DRUG: Gemcitabine|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Multiple Dose Genakumab for Injection in Chinese Healthy Adults
Status: RECRUITING
Conditions: Interstitial Lung Disease
Interventions: DRUG: Genakumab injection|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SCHEDULE - Scandinavian Heart Transplant Everolimus de Novo Study With Early Calcineurin Inhibitor (CNI) Avoidance
Status: COMPLETED
Conditions: Renal Function and Chronic Allograft Vasculopathy
Interventions: DRUG: Cyclosporine|DRUG: Mycophenolate mofetil|DRUG: Corticosteroids|DRUG: Everolimus|DRUG: Anti Thymocyte Globulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pyrimethamine as an Inhibitor of NRF2 in HPV-unrelated Locally Advanced Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Head and Neck Cancer|Cancer of the Head and Neck
Interventions: DRUG: Pyrimethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect Of Chronobıologıcal Nutrıtıon On Premature Babıes
Status: NOT_YET_RECRUITING
Conditions: Nutrition, Healthy
Interventions: BEHAVIORAL: choronobiological nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: IDO and PD-L1 Peptide Based Immune-Modulatory Therapeutic (IO102-IO103) in Combination With Pembrolizumab for BCG-Unresponsive or Intolerant, Non-Muscle Invasive Bladder Cancer
Status: RECRUITING
Conditions: High Risk Non-Muscle Invasive Bladder Urothelial Carcinoma|Stage 0a Bladder Cancer AJCC v8|Stage 0is Bladder Cancer AJCC v8|Stage I Bladder Cancer AJCC v8
Interventions: BIOLOGICAL: PD-L1/IDO Peptide Vaccine|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increasing Psychological Resilience in Combat Soldiers Applying Advanced Eye-Tracking-Based Attention Bias Modification
Status: ACTIVE_NOT_RECRUITING
Conditions: PTSD|Depression|Anxiety Disorders
Interventions: BEHAVIORAL: Gaze-Contingent Feedback Training|BEHAVIORAL: Attention Bias Modification|BEHAVIORAL: Neutral Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Intranasal Glutathione in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease (PD)
Interventions: DRUG: Intranasal glutathione - (in)GSH|DRUG: Intranasal glutathione - (in)GSH|DRUG: Saline Intranasal Delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of the NG Shield, a Device Intended to Reduce Pain and Discomfort Level Related to Nasogasstric Tube Usage
Status: COMPLETED
Conditions: Intubation, Nasogastric
Interventions: DEVICE: NG Shield
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized Clinical Trial of Three Drug Combinations for Late-Stage Gambiense Human African Trypanosomiasis
Status: TERMINATED
Conditions: Trypanosomiasis, African
Interventions: DRUG: melarsoprol 1.8 mg/kg/d, 10d + nifurtimox 15/20 mg/kg/d, 10d|DRUG: melarsoprol 1.8 mg/kg/d, 10d + eflornithine 400 mg/kg/d, 7d|DRUG: nifurtimox 15/20 mg/kg/d 10d + eflornithine 400 mg/kg/d 7d
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carbon Monoxide Hyperbaric Oxygen With Steroid Therapy
Status: NOT_YET_RECRUITING
Conditions: Carbon Monoxide Poisoning|Carbon Monoxide Intoxication|Carbon Monoxide Encephalopathy|Carbon Monoxide-induced Parkinsonism
Interventions: DRUG: saline placebo|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Time-restricted Enteral Nutrition Versus Continuous Enteral Nutrition in Patients With Severe Stroke
Status: RECRUITING
Conditions: Stroke|Time Restricted Feeding
Interventions: OTHER: Time-restricted enteral nutrition therapy group|OTHER: Continuous enteral nutrition control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of AMR and ADR Between Endocuff Vision-assisted and Conventional Colonoscopy: a Multicenter Randomized Trial
Status: UNKNOWN
Conditions: Colorectal Neoplasms
Interventions: DEVICE: CC followed by EC|DEVICE: EC followed by CC|DEVICE: 2x EC|DEVICE: 2x CC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Melanin and Dermal Uptake of Thirdhand Cigarette Smoke
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: OTHER: Wear clothing that has been exposed to cigarette smoke for 3 hours.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Bioresorbable Sheet to Prevent Intra-Abdominal Adhesions in Colorectal Surgeries
Status: COMPLETED
Conditions: Adhesions
Interventions: DEVICE: Polylactic Acid Sheet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Rifabutin on the Pharmacokinetics of Oral Cabotegravir in Healthy Subjects
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus|HIV Infections
Interventions: DRUG: Cabotegravir|DRUG: Rifabutin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a New Serum-free DTaP-IPVvero Combination Vaccine
Status: COMPLETED
Conditions: Active Immunization
Interventions: BIOLOGICAL: DTaP-IPV vero vaccine|BIOLOGICAL: DTaP-IPV mkc vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of 2-year Administration of CP-945,598 on Weight Loss Efficacy and Safety.
Status: TERMINATED
Conditions: Obesity
Interventions: DRUG: CP-945,598 Treatment B|DRUG: CP-945,598 Treatment A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Project Wellness Pilot Feasibility Randomized Controlled Trial
Status: COMPLETED
Conditions: Diabetes, Gestational
Interventions: BEHAVIORAL: Physical Activity Intervention|OTHER: Wellness Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase 3 Study of TG103 Injection Monotherapy in Treatment of Type 2 Diabetes Mellitus
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: TG103|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Evaluation of Piezo and Endonasal Osteotomy Methods on Postoperative Healing Process in Septorhinoplasty
Status: RECRUITING
Conditions: Nasal Deformity, Acquired|Septum; Deviation, Congenital
Interventions: PROCEDURE: Endonasal osteotomy|DEVICE: Piezo assisted osteotomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Window of Opportunity Study Targeting the Inflammatory Milieu
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage IA Breast Cancer|Stage IB Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer
Interventions: DIETARY_SUPPLEMENT: Omega-3 fatty acid|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Cardiopulmonary Bypass, and Sevoflurane or Propofol Anesthesia, on Tissue Oxygen Saturation.
Status: COMPLETED
Conditions: NIR Spectroscopy
Interventions: PROCEDURE: NIRS during VOT|PROCEDURE: General anaesthesia with propofol use|PROCEDURE: General anaesthesia with sevoflurane use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ability of Late Sodium or Calcium Current Block to Balance the ECG Effects of Potassium Current Block
Status: COMPLETED
Conditions: Drug-induced QT Prolongation|Pharmacokinetics|Pharmacodynamics
Interventions: DRUG: Dofetilide|DRUG: Mexiletine|DRUG: Lidocaine|DRUG: Moxifloxacin|DRUG: Diltiazem|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ligasure Versus Diathermy Haemorrhoidectomy Under Local Anesthesia
Status: COMPLETED
Conditions: Hemorrhoids
Interventions: PROCEDURE: diathermy haemorrhoidectomy under espinal anesthesia|PROCEDURE: diathermy haemorrhoidectomy under local anesthesia|PROCEDURE: Ligasure haemorrhoidetomy under spinal anestesia|PROCEDURE: Ligasure haemorrhoidectomy under local anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Metformin in HNSCC to Investigate the Effects of MF, Tumor Genotype and MF-genotype Interactions, on Tumor Metabolism and Anoikis
Status: TERMINATED
Conditions: Cancer of Head and Neck
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Comparing Platelet Transfusion Volumes in Premature Babies
Status: NOT_YET_RECRUITING
Conditions: Thrombocytopenia|Transfusion
Interventions: OTHER: Dose of platelet transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Altering Memories That Increase Risk of Relapse in Alcohol Use Disorders
Status: COMPLETED
Conditions: Alcohol Use Disorder|Alcohol Dependence
Interventions: DRUG: Rapamycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Deferiprone Treatment in Patients With Pantothenate Kinase-Associated Neurodegeneration
Status: COMPLETED
Conditions: Pantothenate Kinase-Associated Neurodegeneration
Interventions: DRUG: Deferiprone oral solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bilateral Interconnected DIEP Flap Based on One Vessel Pedicle for Breast Reconstruction
Status: COMPLETED
Conditions: Mammaplasty
Interventions: PROCEDURE: DIEP|PROCEDURE: Interconnected DIEP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Caspofungin Acetate (MK0991) for the Treatment of Esophageal Candidiasis or Invasive Candidiasis in Chinese Adults (MK-0991-066)
Status: COMPLETED
Conditions: Fungal Infection
Interventions: DRUG: caspofungin acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Caffeine on Cerebral Blood Flow
Status: COMPLETED
Conditions: Cardiovascular System
Interventions: OTHER: Placebo|OTHER: Anhydrous caffeine (45mg)|OTHER: Anhydrous caffeine (120mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Efficacy and Safety Study of Rimonabant for Treatment of Nonalcoholic Steatohepatitis (NASH) in Patients With Type 2 Diabetes
Status: TERMINATED
Conditions: Fatty Liver
Interventions: DRUG: Rimonabant|DRUG: Placebo (for Rimonabant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Olanzapine in the Long-term Treatment for Bipolar I Disorder, Depressed
Status: COMPLETED
Conditions: Bipolar I Disorder
Interventions: DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Inter-dental Brush to Dental Floss
Status: COMPLETED
Conditions: Gingivitis
Interventions: DEVICE: IB = Interdental brush, the intervention|DEVICE: DF = Dental floss, the positive control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety and Effectiveness of Zostavax™ in Subjects 50 - 59 Years of Age (V211-022)
Status: COMPLETED
Conditions: Shingles
Interventions: BIOLOGICAL: Zoster Vaccine, Live (Zostavax™)|BIOLOGICAL: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Aerobic Exercise and Covid-19 Survivors With Post-Intensive Care Syndrome (Pics)
Status: COMPLETED
Conditions: COVID-19|Post Intensive Care Syndrome
Interventions: OTHER: Aerobic Exercise Training|OTHER: Home Plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: GS 5885 Administered Concomitantly With GS-9451, Tegobuvir and Ribavirin (RBV) in Chronic Genotype 1 Hepatitis C Virus (HCV) Infection
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: GS-5885|DRUG: Tegobuvir|DRUG: GS-9451|DRUG: ribavirin tablet|DRUG: GS-5885
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DOuble SEquential External Defibrillation for Refractory VF Pilot Study
Status: COMPLETED
Conditions: Ventricular Fibrillation
Interventions: PROCEDURE: Vector change defibrillation|PROCEDURE: Double-sequential defibrillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Intelligent Case Manage Platform in Liver Transplant Recipients
Status: NOT_YET_RECRUITING
Conditions: Liver Transplant Disorder|Self Efficacy|Quality of Life
Interventions: OTHER: Intelligent Case Manage Platform (ICMP) and self-management program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Metronidazole vs Placebo as Adjuncts to Periodontal Surgery for Patients Positive to Porphyromonas Gingivalis
Status: COMPLETED
Conditions: Periodontitis|Surgery
Interventions: DRUG: Metronidazole|DRUG: Placebo|PROCEDURE: periodontal surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Home-based Family Caregiver-delivered Music and Reading Interventions for People With Dementia
Status: COMPLETED
Conditions: Dementia|Dementia, Vascular|Dementia With Lewy Bodies|Dementia, Mixed|Dementia Alzheimers|Behavioural and Psychiatric Symptoms of Dementia|Depression|Quality of Life
Interventions: OTHER: Music Intervention|OTHER: Reading Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Multicenter Study of Peritransplantation Immunosuppression for Mismatched Hematopoietic Cell Transplantation After Reduced Intensity Conditioning
Status: TERMINATED
Conditions: Patients Receiving Mismatched Allogeneic HCT
Interventions: DRUG: immunosuppression
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Oblimersen in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: oblimersen sodium|DRUG: paclitaxel|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term, Open-label Follow-up Treatment of Patients With A-fib Who Have Been Previously Treated With BIBR 1048
Status: TERMINATED
Conditions: Atrial Fibrillation|Stroke
Interventions: DRUG: dabigatran etexilate|DRUG: dabigatran etexilate|DRUG: dabigatran etexilate|DRUG: dabigatran etexilate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Stage IV Melanoma|Recurrent Melanoma
Interventions: DRUG: gp100 antigen|DRUG: interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT