pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Ultrastructural Collagen Markers in Ehlers Danlos Syndromes
Status: ENROLLING_BY_INVITATION
Conditions: Ehlers-Danlos Syndrome|Classical Ehlers-Danlos Syndrome|Hypermobile EDS (hEDS)
Interventions: OTHER: Skin Biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Casodex/Zoladex Biomarkers in Localised Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: bicalutamide (Casodex), goserelin (Zoladex)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomised Evaluation of Molecular Guided Therapy for Diffuse Large B-cell Lymphoma With Bortezomib
Status: COMPLETED
Conditions: Lymphoma, Large B-Cell, Diffuse
Interventions: DRUG: Intravenous|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Supraclavicular Brachial Plexus Block in Elderly
Status: COMPLETED
Conditions: Arm Injuries|Anesthesia
Interventions: DEVICE: Elderly population, Middle aged population
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Telemedicine Prenatal Care Model on Low Risk Pregnants: The m@Mae-e Study
Status: NOT_YET_RECRUITING
Conditions: Pregnancy; Mental Disorders|COVID-19 Pandemic|Prenatal Stress
Interventions: OTHER: Telemedicine appointment|OTHER: Face-to-face appointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: COPD: Oral Nutrition Supplements vs. Energy- and Protein Dense in Between Meal Snacks.
Status: COMPLETED
Conditions: Malnutrition
Interventions: OTHER: In between meals snacks (Snacks-group)|OTHER: Oral nutrition supplement (ONS-group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Erlotinib Hydrochloride or Crizotinib and Chemoradiation Therapy in Treating Patients With Stage III Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Stage III Non-Small Cell Lung Cancer AJCC v7|Stage IIIA Non-Small Cell Lung Cancer AJCC v7|Stage IIIB Non-Small Cell Lung Cancer AJCC v7
Interventions: RADIATION: Radiation Therapy|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Crizotinib|DRUG: Erlotinib|DRUG: Etoposide|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abobotulinumtoxina Efficacy in Post-Traumatic Headache
Status: COMPLETED
Conditions: Post-Traumatic Headache
Interventions: DRUG: AbobotulinumtoxinA|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Catheter Ablation for Recently Diagnosed Paroxysmal Atrial Fibrillation
Status: WITHDRAWN
Conditions: Atrial Fibrillation
Interventions: DRUG: Antiarrhythmic drug|PROCEDURE: Catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measuring Blood Flow in the Brain After Epileptic Activity
Status: COMPLETED
Conditions: Epilepsy|Depression|Postictal Delirium|Electroconvulsive Therapy
Interventions: DRUG: Paracetamol|DRUG: Nimotop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study With Iressa in Resistant Cytokeratin-Positive Tumor Cells Circulating in the Blood of Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: ZD1839
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-finding Study of GSK2636771 When Administered in Combination With Enzalutamide in Male Subjects With Metastatic Castration-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: GSK2636771|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: APHP Plateform of Normothermic Perfusion for Rehabilitation of Hepatic Grafts
Status: UNKNOWN
Conditions: Liver Diseases
Interventions: PROCEDURE: Liver transplantation of a graft after assessment by normothermic perfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Desloratadine (MK-4117) in Japanese Participants With Seasonal Allergic Rhinitis (MK-4117-204)
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Desloratadine 5 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Experimental Study to Compare Treatment Response and Toxicities of Concurrent Chemoradiation With Weekly Cisplatin and Three Weekly Cisplatin in Locally Advanced Head and Neck Cancer.
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Cisplatin 40 mg/m2|DRUG: Cisplatin 100 mg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Joovvin' for Your Skin Health Study
Status: COMPLETED
Conditions: Skin Inflammation|Acne|Skin Diseases|Dermatological Non-Disease|Skin Condition|Eczema
Interventions: DEVICE: Joovv Mini
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temporal Profile of Serum Vitamin D Levels in Foot and Ankle Fusion Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Ankle Arthrodesis|MTP Arthrodesis
Interventions: DRUG: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Pain Neuroscience Education in Patients With Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: OTHER: Preoperative Pain Neuroscience Education|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Microneedling Daycare Procedure and Tazarotene 0.1% Gel Local Application in Acne Scarring
Status: COMPLETED
Conditions: Atrophic Post Acne Scarring
Interventions: DRUG: tazarotene gel 0.1%|DEVICE: Microneedling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Potential Impact (Benefit) of Preventative Treatment With Topamax on the Effectiveness of Axert in the Acute Treatment of Migraine
Status: COMPLETED
Conditions: Migraine|Classic Migraine|Common Migraine
Interventions: DRUG: topiramate; almotriptan malate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ocrelizumab Compared to Placebo in Patients With Active Rheumatoid Arthritis Who Don't Have a Response to Anti-TNF-α Therapy (SCRIPT)
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Leflunomide|DRUG: Methotrexate|DRUG: Ocrelizumab|DRUG: Ocrelizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Peak Airway Pressure and Gastric Insufflation in Manual Ventilation and Pressure-controlled Ventilation With Facemask During Anesthesia Induction in Children
Status: COMPLETED
Conditions: Elective Urologic Surgeries
Interventions: OTHER: manual ventilation|OTHER: pressure-controlled ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: ALaCART-B: Acute Leukemia and Chimeric Antigen Receptor-T Cell Therapy for B-lymphoblastic Leukemia.
Status: RECRUITING
Conditions: Lymphoblastic Leukemia, Acute, Childhood|Lymphoblastic Leukemia|Lymphoblastic Leukemia, Acute Adult|Lymphoblastic Leukemia in Children|CAR|CAR T-Cell-Related Encephalopathy Syndrome
Interventions: BIOLOGICAL: CAR T-cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antihypertensive Medications and the Risk of Sepsis
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan|DRUG: Other angiotensin-receptor blockers (ARBs)|DRUG: Angiotensin-converting enzyme inhibitors (ACEIs)|DRUG: Other major antihypertensive medication classes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bimodal, CROS and Severe Profound Hearing Loss Study
Status: COMPLETED
Conditions: Cochlear Implant|Severe-Profound Hearing Loss|Hearing Loss, Bilateral|Hearing Loss, Cochlear
Interventions: DEVICE: Fitting strategy of cohlear implant of hearing aid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Thalidomide, a- Interferon +/- Octreotide in Patients With Unresectable Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Liver|Cancer
Interventions: DRUG: Thalidomide, alpha interferon|DRUG: Thalidomide, interferon, Octreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tight Glycemic Control in Acute Exacerbations of COPD
Status: UNKNOWN
Conditions: COPD|Hyperglycemia
Interventions: DRUG: tight insulin treatment in patients hospitalized with COPD exacerbation|PROCEDURE: tight glycemic control
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Follow-up Study to Assess Resistance to ABT-072 in HCV-infected Subjects Administered ABT-072 in Prior ABT-072 Studies
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: ABT-072
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Study of RO7105705 in Healthy Participants and Participants With Mild-to-Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Placebo|DRUG: RO7105705
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation and Dose Expansion Study of GAS in Subjects With Metastatic Pancreatic Adenocarcinoma
Status: RECRUITING
Conditions: Metastatic Pancreatic Adenocarcinoma
Interventions: COMBINATION_PRODUCT: Gemcitabine 800mg/m2 + Nab-paclitaxel 100mg/m2 + S-1 (dose according to BSA)|COMBINATION_PRODUCT: Gemcitabine 800mg/m2 + Nab-paclitaxel 125mg/m2 + S-1 (dose according to BSA)|COMBINATION_PRODUCT: Gemcitabine 1000mg/m2 + Nab-paclitaxel 125mg/m2 + S-1 (dose according to BSA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of ABT-874 in Subjects With Moderate to Severe Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Anti IL-12 monoclonal antibody/ABT-874|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Local Anesthesia in Molar Teeth With Molar Incisor Hypomineralization
Status: COMPLETED
Conditions: Molar Incisor Hypomineralization
Interventions: DIAGNOSTIC_TEST: Evaluation of cold test|DIAGNOSTIC_TEST: Evaluation of electrical pulp test|DIAGNOSTIC_TEST: Evaluation of pain during the treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immersive Virtual Reality in Orthopedics
Status: RECRUITING
Conditions: Virtual Reality|Orthopedic
Interventions: DEVICE: Hypnotic virtual reality support using hypnosis software Hypno-VR®|DEVICE: No Hypnotic virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial Evaluating PCSK9 Antibody in Subjects With LDL Receptor Abnormalities
Status: COMPLETED
Conditions: Homozygous Familial Hypercholesterolemia
Interventions: BIOLOGICAL: Evolocumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Abemaciclib (LY2835219) in Native Chinese Participants With Advanced and/or Metastatic Cancers
Status: COMPLETED
Conditions: Advanced Cancer|Metastatic Cancer
Interventions: DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Goal-directed Hemodynamic Management and Kidney Injury After Radical Nephrectomy
Status: NOT_YET_RECRUITING
Conditions: Renal Cell Carcinoma|Nephrectomy|Hemodynamic Management|Acute Kidney Injury|Chronic Kidney Diseases
Interventions: OTHER: Targeted hemodynamic management|OTHER: Routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Insulin Detemir in Combination With OAD in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir|DRUG: insulin NPH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Peritonitis in Automated Peritoneal Dialysis
Status: COMPLETED
Conditions: Secondary Peritonitis
Interventions: DEVICE: Peritonitis treatment placed in APD|DEVICE: Peritonitis treatment with one exchange in CAPD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Combinations of Opioid and Non-opioid Analgesics for Acute Periradicular Abscess
Status: COMPLETED
Conditions: Periapical Abscess
Interventions: DRUG: Fixed-dose oral tablet of codeine/ acetaminophen every 4 hours for 3 days|DRUG: Fixed-dose oral tablet of tramadol/ acetaminophen every 4 hours for 3 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation Of A New Two-Component Self-Etch Universal Adhesive
Status: COMPLETED
Conditions: Composite Restorations|Tooth Lesions
Interventions: PROCEDURE: Adhesive: OptiBond XTR; Composite: Herculite Ultra|PROCEDURE: Adhesive: OptiBond FL; Composite: Herculite Ultra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Safety Study of Intranasal Etripamil for the Termination of Spontaneous Episodes of Paroxysmal Supraventricular Tachycardia (PSVT). NODE-302
Status: TERMINATED
Conditions: Paroxysmal Supraventricular Tachycardia
Interventions: DRUG: Etripamil NS 70 mg|DEVICE: Aptar Pharma Nasal Spray Bidose System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Complex Training On Pain and Posture In School Going Children With Heavy Bags Packs
Status: RECRUITING
Conditions: Posture Disorders in Children
Interventions: OTHER: Lumber strengthening exercises|OTHER: General cervical Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Hammock Positioning's Influence on the Electromyographic Activity in the Flexor Muscles in Newborn Preterm
Status: UNKNOWN
Conditions: Preterm Birth
Interventions: DEVICE: hammock|DEVICE: containment nest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Olaratumab (LY3012207), Doxorubicin, and Ifosfamide in Participants With Advanced or Metastatic Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: Olaratumab|DRUG: Doxorubicin|DRUG: Ifosfamide|DRUG: Mesna
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Investigate the Pharmacokinetics, Efficacy, Safety and Immunogenicity of a Recombinant FVIII in Patients With Severe Hemophilia A
Status: COMPLETED
Conditions: Hemophilia A
Interventions: BIOLOGICAL: Human-cl rhFVIII|BIOLOGICAL: Kogenate FS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1a Study in Healthy Smokers to Investigate the Effect With MMI-0100 on Airway Inflammation in Induced Sputum After Challenge With Inhaled Lipopolysaccharide
Status: UNKNOWN
Conditions: Acute Inflammatory Response to Non-antigenic Stimulus
Interventions: DRUG: MMI-0100|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cytarabine With or Without SCH 900776 in Treating Adult Patients With Relapsed Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Megakaryoblastic Leukemia|Adult Acute Monoblastic Leukemia|Adult Acute Monocytic Leukemia|Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With Maturation|Adult Acute Myeloid Leukemia With Minimal Differentiation|Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1|Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3-MLL|Adult Acute Myeloid Leukemia Without Maturation|Adult Acute Myelomonocytic Leukemia|Adult Erythroleukemia|Adult Pure Erythroid Leukemia|Alkylating Agent-Related Acute Myeloid Leukemia|Recurrent Adult Acute Myeloid Leukemia
Interventions: DRUG: Cytarabine|DRUG: CHK1 Inhibitor SCH 900776|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Relationship Between Neuropathic Complaints and Central Sensitization in Fibromyalgia
Status: RECRUITING
Conditions: Central Sensitisation|Fibromyalgia|Neuropathic Pain
Interventions: DIAGNOSTIC_TEST: Central sensitization inventory|DIAGNOSTIC_TEST: Widespread pain index|DIAGNOSTIC_TEST: Symptom severity scale|OTHER: Fibromyalgia impact questionnaire|DIAGNOSTIC_TEST: Hospital Anxiety and Depression Scale|DIAGNOSTIC_TEST: Self-Leeds Assessment of Neuropathic Symptoms and Signs
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate Dostarlimab Plus Carboplatin-paclitaxel Versus Placebo Plus Carboplatin-paclitaxel in Participants With Recurrent or Primary Advanced Endometrial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Neoplasms
Interventions: BIOLOGICAL: Dostarlimab|DRUG: Placebo matching dostarlimab|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Niraparib|DRUG: Placebo matching Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Phase 2 Study Comparing the Effects of AR Inhibition With/Without SRC or MEK Inhibition in Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: degarelix|DRUG: enzalutamide|DRUG: trametinib|DRUG: dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Different Surgical Techniques for the Treatment of Multiple Gingival Recessions With Porcine Collagen Matrix
Status: UNKNOWN
Conditions: Gingival Recession|Xenograft Model|Gingival Recession, Generalized
Interventions: PROCEDURE: tunnel technique for Root coverage with Porcine collagen Matrix|PROCEDURE: extended fla technique for Root coverage with Porcine collagen Matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Pregabalin in Ureteroscopy
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Stone|Pain, Postoperative|Addiction|Opioid Use
Interventions: DRUG: Pregabalin 300mg|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanical Heat Recovery Ventilation on House Dust Mite Sensitive Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: Mechanical Heat Recovery Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic And Dietary Effects Of The Sublimated Mare's Milk Supplement In Patients With Non-Alcoholic Steatohepatitis
Status: COMPLETED
Conditions: Non-alcoholic Steatohepatitis
Interventions: DIETARY_SUPPLEMENT: Sublimated mare's milk|DRUG: Ursodeoxycholic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cool vs Room-temperature Artificial Tears
Status: COMPLETED
Conditions: Diabetic Retinopathy With Macular Edema of Both Eyes (Diagnosis)|Central Retinal Vein Occlusion With Macular Edema|Exudative Age-Related Macular Degeneration, Unspecified Eye|Cystoid Macular Edema|Ocular Surface Disease|Dry Eye Sensation|Eye Pain
Interventions: DRUG: Refresh Plus Preservative-free Lubricant Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate How Mirabegron Enters and Leaves the Bloodstream According to Age and Sex
Status: COMPLETED
Conditions: Healthy Volunteers|Pharmacokinetics of Mirabegron
Interventions: DRUG: Mirabegron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prophylactic Antibiotic Use in Transarterial Chemoembolization for Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Antibiotic Prophylaxis
Interventions: DRUG: Ceftriaxone Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: MRI in Evaluating Early Response to Chemotherapy in Women Receiving Chemotherapy for Infiltrating Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: docetaxel|DRUG: epirubicin hydrochloride|PROCEDURE: conventional surgery|PROCEDURE: dynamic contrast-enhanced magnetic resonance imaging|PROCEDURE: neoadjuvant therapy|PROCEDURE: radiomammography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: Chronic Hepatitis C Treatment by Pegylated Interferon and Ribavirin in Naive Egyptian Patients (ANRS 1211)
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: pegylated interferon alpha2a|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Intraperitoneal Gemcitabine for Resectable Pancreatic Adenocarcinoma
Status: TERMINATED
Conditions: Pancreatic Adenocarcinoma
Interventions: DRUG: Intraperitoneal Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Dietary Protein on Satiety, Food Intake and Thermic Effect of Food
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: OTHER: Control Meal|OTHER: Low Protein Meal|OTHER: Moderate Protein Meal|OTHER: High Protein Meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effects of Laser Guided Cervical Proprioceptive Exercises in Patients With Cervical Radiculopathy
Status: RECRUITING
Conditions: Cervical Radiculopathy
Interventions: OTHER: Laser guided proprioceptive exercises|OTHER: Routine Physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrated CBT for Cannabis Dependence With Co-occurring Anxiety Disorders
Status: COMPLETED
Conditions: Cannabis Dependence|Anxiety Disorders|Cannabis Use Disorder|Cannabis Abuse
Interventions: BEHAVIORAL: Cognitive-Behavioral Therapy|BEHAVIORAL: Motivation Enhancement Therapy|BEHAVIORAL: Integrated Cannabis and Anxiety Reduction Treatment|BEHAVIORAL: False Safety Behavior Elimination Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Biomarkers of Airway Inflammation (0000-128)
Status: COMPLETED
Conditions: Airway Inflammation
Interventions: DRUG: fluticasone propionate|DRUG: Comparator: Placebo to fluticasone|DRUG: Comparator: Lipopolysaccharide (LPS)|DRUG: Comparator: albuterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Randomized Controlled Trial Comparing Co2 vs. Air in Colonoscopy in Sedated Patients
Status: UNKNOWN
Conditions: Pain, Satisfaction
Interventions: OTHER: Air insufflation use in colonoscopy|OTHER: CO2 use in colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Fructose Reduction on Non-alcoholic Fatty Liver Disease (NAFLD) and Metabolic Syndrome in Overweight Children
Status: UNKNOWN
Conditions: Non-alcoholic Fatty Liver Disease
Interventions: BEHAVIORAL: dietary intervention mainly focusing on fructose reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Image-guided SBRT for Adrenal Gland Metastasis in Oligometastatic Patients
Status: UNKNOWN
Conditions: Adrenal Gland Metastases
Interventions: RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oscillating Positive Expiratory Pressure Therapy for Patients With Thoracic Neoplasms Undergoing Chest Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer|Mediastinal Tumor|Pleural Tumor
Interventions: DEVICE: oscillating positive expiratory pressure device|PROCEDURE: Pulmonary rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma
Status: TERMINATED
Conditions: Oropharyngeal Cancer
Interventions: PROCEDURE: Transoral Robotic Surgery (TORS)|PROCEDURE: Modified Barium Swallow (MBS)|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PFx Closure System in Subjects With Cryptogenic Stroke,Transient Ischemic Attack,Migraine or Decompression Illness(PFO)
Status: SUSPENDED
Conditions: Patent Foramen Ovale
Interventions: DEVICE: PFx catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Thyme and Sumac on the Thermic Effect of Food and Comparison Between Warm and Cold Temperament People
Status: UNKNOWN
Conditions: Effects of; Food, Allergic
Interventions: OTHER: Zataria multiflora Boiss|OTHER: Sumac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Study of ATI-1777 in Patients 12 to 65 Years Old With Mild to Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: ATI-1777 2.0% w/w|DRUG: ATI-1777 1.0% w/w|DRUG: ATI-1777 0.5% w/w|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RO5045337 in Combination With Cytarabine in Patients With Acute Myelogenous Leukemia
Status: COMPLETED
Conditions: Myelogenous Leukemia, Acute
Interventions: DRUG: RO5045377|DRUG: RO5045377|DRUG: cytarabine|DRUG: cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiology as Guidance to Evaluate the Direct Impact of Coronary Lesion Treatment: The PREDICT Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease|Stable Angina|Unstable Angina|Ischemic Heart Disease|Chest Pain
Interventions: PROCEDURE: post-PCI FFR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Melatonin for Prevention of Kidney Injury
Status: RECRUITING
Conditions: Acute Kidney Injury|Adverse Drug Event
Interventions: DRUG: Melatonin|OTHER: Placebo Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Three Toothpastes for the Prevention and Reduction of White Spot Lesions
Status: COMPLETED
Conditions: White Spot Lesion|Orthodontic Treatment|Decalcification; Teeth
Interventions: OTHER: Clinpro™ 5000|OTHER: Clinpro™ Tooth Crème|OTHER: MI-Paste Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Minimum Effective Duration of Intrauterine Balloon Tamponade for the Management of Postpartum Hemorrhage
Status: ENROLLING_BY_INVITATION
Conditions: Postpartum Hemorrhage, Immediate
Interventions: DEVICE: Intrauterine balloon tamponade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous PRP and Focal Shock Waves for Erectile Dysfunction
Status: RECRUITING
Conditions: Erectile Dysfunction
Interventions: OTHER: Platelet-rich plasma|OTHER: Shock waves therapy|OTHER: Placebo PRP|OTHER: Sham shock waves therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Very Low-calorie Diet & Cardiometabolic Health
Status: RECRUITING
Conditions: Healthy
Interventions: OTHER: Very low calorie diet with low protein content (VLCD-LP group)|OTHER: Very low calorie diet with high protein content (VLCD-HP group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 1 Study to Assess the Safety, PK and PD of INBRX-101 in Adults With Alpha-1 Antitrypsin Deficiency
Status: COMPLETED
Conditions: Alpha-1 Antitrypsin Deficiency|AATD
Interventions: DRUG: INBRX-101/rhAAT-Fc
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Radial Artery Cannulation Affect the Perfusion Index(PI) of the Hand in Liver Transplant Operations?
Status: NOT_YET_RECRUITING
Conditions: Perfusion; Complications|Arterial Catheterization, Peripheral
Interventions: PROCEDURE: radial artery cannulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis
Status: COMPLETED
Conditions: Chronic Periodontitis|Aggressive Periodontitis|Presence / Absence of EBV
Interventions: PROCEDURE: dental root planing|PROCEDURE: dental root planing|PROCEDURE: dental root planing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The "Power 15 Study": Safety Study of Inhalation of Ventavis With the Power Disc-15 Setting
Status: TERMINATED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Iloprost PD-6|DRUG: Iloprost PD-15
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project RAD: A Brief Intervention for Young Adult Alcohol or Marijuana Users
Status: UNKNOWN
Conditions: Alcohol; Use, Problem|Marijuana Usage
Interventions: BEHAVIORAL: Narrative Based Therapuetic Assessment (NbTa)|BEHAVIORAL: Health Education Control Condition (HE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome Patients to Determine the Recommended Dose of CYAD-02
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: BIOLOGICAL: CYAD-02|DRUG: ENDOXAN|DRUG: Fludara
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MySTYLE: Online Family-based HIV Prevention for Non-heterosexual Black Adolescent Males in the South
Status: COMPLETED
Conditions: Hiv|Adolescent Behavior|Family Relations|Sexual Orientation
Interventions: BEHAVIORAL: MySTYLE|OTHER: Waitlist Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Hyperuricemia
Interventions: OTHER: Low-fructose diet, isocaloric|DRUG: Allopurinol|DRUG: Placebo|OTHER: Low-fructose, hypocaloric
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tregs CD25 CXCL9 in Vitiligo
Status: NOT_YET_RECRUITING
Conditions: Vitiligo|CD25 Deficiency|Chemokine (C-X-C Motif)|Tregs
Interventions: DIAGNOSTIC_TEST: ELIZA , Flowcytometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ExtraCorporeal Membrane Oxygenation in the Therapy for REfractory Septic Shock With Cardiac Function Under Estimated
Status: RECRUITING
Conditions: Extracorporeal Membrane Oxygenation|Septic Shock|Septic Cardiomyopathy|Cardiogenic Shock
Interventions: PROCEDURE: Extracorporeal Membrane Oxygenation (ECMO)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Treatment With N- Acetylcysteine on Visual Outcomes in Patients With Retinitis Pigmentosa
Status: UNKNOWN
Conditions: Retinitis Pigmentosa
Interventions: DRUG: Prescribe N-acetylcysteine tablets|DRUG: Prescribe placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Connected Healthcare for Individuals Living at Home With Chronic Conditions
Status: COMPLETED
Conditions: Medication Adherence|Medication Compliance|Medication Nonadherence|Hypertension|Diabetes|Arthritis|Chronic Pain|Anxiety Depression|Asthma
Interventions: DEVICE: Spencer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Merestinib In Non-Small Cell Lung Cancer And Solid Tumors
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung|Solid Tumor
Interventions: DRUG: Merestinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anxiety, Pain, and Quality of Life in Orthodontic Treatment
Status: COMPLETED
Conditions: Malocclusion|Pain|Anxiety|Quality of Life
Interventions: OTHER: Conventional fixed treatment|OTHER: Clear aligner treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Bupivacaine at Cesarean Delivery to Decrease Post-operative Pain
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Liposomal bupivacaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Biomarker Study of Dietary Grape-derived Low Dose Resveratrol for Colon Cancer Prevention
Status: WITHDRAWN
Conditions: Colon Cancer
Interventions: DIETARY_SUPPLEMENT: grapes|DIETARY_SUPPLEMENT: grapes|DIETARY_SUPPLEMENT: grapes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 30-Day Trial of Oral Valtrex or Valtrex Plus Aspirin on Shedding of HSV DNA in Tears and Saliva of Volunteers
Status: UNKNOWN
Conditions: Herpes Simplex
Interventions: DRUG: valacyclovir hydrochloride|DRUG: placebo|DRUG: valacyclovir plus aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Supporting Self-management of Chronic Pain
Status: COMPLETED
Conditions: Chronic Pain Syndrome|Chronic Pain|Chronic Pain Due to Injury|Chronic Pain Due to Trauma|Chronic Pain Due to Malignancy (Finding)|Chronic Pain Post-Procedural|Chronic Pain Hip|Chronic Pain, Widespread
Interventions: OTHER: The Navigator Tool Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effects of High-Dose Resveratrol in Non-Diabetic Obese Males
Status: COMPLETED
Conditions: Obesity|Diabetes
Interventions: DRUG: Resveratrol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Placebo-Controlled, Crossover-Design Study of the Effects of Low Dose Naltrexone
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: 4.5 mg Naltrexone|DRUG: Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Pharmacokinetics of ES-481 in Adult Patients With Drug Resistant Epilepsy
Status: RECRUITING
Conditions: Drug Resistant Epilepsy
Interventions: DRUG: ES-481|DRUG: Placebo|DRUG: Open-Label Extension Study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Design and Evaluation of Mobile X-ray for Rapid and Accurate Diagnosis of Thoracic Disease
Status: TERMINATED
Conditions: Thoracic Diseases
Interventions: DEVICE: Dual energy and tomosynthesis xray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Alpha-Lipoic Acid in Preventing Peripheral Neuropathy in Patients Receiving Chemotherapy for Cancer
Status: COMPLETED
Conditions: Neurotoxicity|Unspecified Adult Solid Tumor, Protocol Specific|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: alpha-lipoic acid|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Bioavailability Study Comparing Treprostinil Diethanolamine Oral Tablets and Oral Solution in Healthy Volunteers
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: treprostinil diethanolamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Drug Trial in Coronary Disease Progression
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Disease|Heart Diseases|Myocardial Ischemia
Interventions: DRUG: aspirin|DRUG: dipyridamole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: QUILT-2.016: Study of AMG 479 With Biologics or Chemotherapy for Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Malignancy|Advanced Solid Tumors|Cancer|Solid Tumors|Tumors
Interventions: DRUG: AMG 479
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Popliteal Nerve Blocks: Effect of Perineural Catheter Tip Location Relative to the Sciatic Nerve Bifurcation on Postoperative Analgesia
Status: COMPLETED
Conditions: Popliteal Nerve Block|Foot Surgery|Ankle Surgery|Popliteal Bifurcation
Interventions: PROCEDURE: Catheter Placed At Bifurcation|PROCEDURE: Catheter Placed 5cm Above Bifurcation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Zoster Eye Disease Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Herpes Zoster Ophthalmicus
Interventions: DRUG: Masked Placebo|DRUG: Masked Oral Valacyclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Belgian Trial Investigating the LifeStream Stent in Complex TASC C and D Iliac Lesions
Status: ACTIVE_NOT_RECRUITING
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: LifeStream Peripheral Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pemetrexed in the Treatment of Patients With Ovarian Cancer Who Have Failed Prior Platinum-Based Chemotherapy
Status: COMPLETED
Conditions: Ovarian Neoplasms|Primary Peritoneal Cancer
Interventions: DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Intraoperative Best Practice Advisory Reminders to Protocolize Insulin Administration Versus Standard Care in Patients at High Risk of Hyperglycemia
Status: ENROLLING_BY_INVITATION
Conditions: Diabetes|Hyperglycemia
Interventions: OTHER: Best Practice Advisory
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth Weight Infants
Status: COMPLETED
Conditions: Anemia of Prematurity
Interventions: OTHER: red blood cell transfusion|OTHER: red blood cell transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Efficacy and Safety of a New Medical Device in the Local Treatment of Diabetic Foot Ulcers
Status: UNKNOWN
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: Dressing with LU3103209 - Dose 1|DEVICE: Dressing with LU3103209 - Dose 2|DEVICE: Dressing without LU3103209
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Sorafenib and Docetaxel in Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Sorafenib (Nexavar)|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tai-chi / Qi-gong in Patients With Patients With Gynecological Malignancies
Status: WITHDRAWN
Conditions: Ovarian Cancer|Primary Peritoneal Cancer|Other Gynecological Cancers
Interventions: OTHER: Tai-chi/Qi-gong
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Apnea and Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment
Status: RECRUITING
Conditions: Obstructive Sleep Apnea|Mild Cognitive Impairment|Subjective Cognitive Impairment
Interventions: DIAGNOSTIC_TEST: Home Sleep Apnea test (HSAT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Remission Induction of Primary Biliary Cholangitis-autoimmune Hepatitis Overlap Syndrome
Status: UNKNOWN
Conditions: Hepatitis, Autoimmune|Cholangitis|Liver Cirrhosis, Biliary|Cholestasis
Interventions: DRUG: Ursodeoxycholic acid combination of immunosuppressive agents|DRUG: Ursodeoxycholic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT