pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Clinical Study to Evaluate the Handling and Safety of AVT06 PFS in Subjects With Chorioretinal Vascular Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Chorioretinal Vascular Disease
Interventions: DEVICE: Patients will receive 1 IVT injection of AVT06 PFS depending on their chorioretinal vascular disease schedule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Multicenter Double Blind Controlled Trial of Human Immune Globulin Therapy in Previously Untreated Patients With Chronic Inflammatory Demyelinating Neuropathy
Status: COMPLETED
Conditions: Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Interventions: DRUG: immune globulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Long-term Immunogenicity of Different Formulations of a Chikungunya Vaccine (V184-005)
Status: COMPLETED
Conditions: Chikungunya Virus Infection
Interventions: BIOLOGICAL: MV-CHIK lyophilised formulation, low dose|BIOLOGICAL: MV-CHIK liquid frozen formulation, low dose|BIOLOGICAL: MV-CHIK SPS® formulation, low dose|BIOLOGICAL: MV-CHIK liquid frozen formulation, high dose|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics and Food Effect of Sarpogrelate HCl CR Formulation in Comparison to Immediate-release Formulation
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Anplag|DRUG: UI03SPG300CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Umbilical Cord Mesenchymal Stem Cells for Immune Reconstitution in HIV-infected Patients
Status: UNKNOWN
Conditions: Human Immunodeficiency Virus|Disorder of Immune Reconstitution
Interventions: DRUG: high dose of MSC|DRUG: low dose of MSC treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: APG-115 in Salivary Gland Cancer Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Salivary Gland Cancer|Salivary Gland Cancer
Interventions: DRUG: APG-115|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Assess Safety and Efficacy of a New Armsleeve in the Management of Arm Lymphoedema
Status: COMPLETED
Conditions: Lymphedema
Interventions: DEVICE: Auto-Adjustable MOBIDERM Armsleeve
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OnabotulinumtoxinA for Trigeminal Neuralgia
Status: RECRUITING
Conditions: Trigeminal Neuralgia
Interventions: DRUG: OnabotulinumtoxinA 100 UNT [Botox]|DRUG: Sodium Chloride 0.9% for Injection, Preservative Free
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Identifying Optimal Smoking Cessation Intervention Components (Cessation)
Status: COMPLETED
Conditions: Smoking|Smoking Cessation|Nicotine Dependence
Interventions: BEHAVIORAL: Counseling before quit attempt|BEHAVIORAL: Minimal In-person counseling during quit attempt|BEHAVIORAL: Intensive in-person counseling during the quit attempt|BEHAVIORAL: Minimal phone counseling during the quit attempt|BEHAVIORAL: Intensive phone counseling during the quit attempt|DRUG: Long Term Nicotine Patch+ Nicotine Gum During Quit Attempt|DRUG: Short Term Nicotine Patch + Nicotine Gum during the quit attempt|DRUG: Pre-Quit Nicotine Gum|DRUG: Pre-Quit Nicotine Patch|DRUG: Pre-Quit Nicotine Patch + Pre-Quit Nicotine Gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Understand How the Study Medicine (PF-06823859) Works in People With Active Idiopathic Inflammatory Myopathies [Dermatomyositis (DM) and Polymyositis (PM)]
Status: RECRUITING
Conditions: Myositis
Interventions: DRUG: PF-06823859|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the ATLAS Medical Device on Pain in Patients With Low Back Pain Due to Lumbar Disc Disease
Status: TERMINATED
Conditions: Lumbar Disc Disease
Interventions: OTHER: Visual analog scale|OTHER: Mac Gill Pain Questionnaire|OTHER: Roland and Morris Disability Questionnaire|OTHER: Quebec questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy, Safety and Dose-Response Study Followed by Open-Label Study of Lofexidine Treatment of Opioid Withdrawal
Status: COMPLETED
Conditions: Opioid Dependence|Acute Opioid Withdrawal Syndrome
Interventions: DRUG: Lofexidine HCl|DRUG: Placebo|DRUG: Open Label Lofexidine HCL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation Science Approach to Enhancing Depression Treatment in Collaborative Depression Care Settings ( DepCare )
Status: RECRUITING
Conditions: Depressive Symptoms
Interventions: BEHAVIORAL: DepCare|BEHAVIORAL: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: RPM CD19-mbIL15-CAR-T Cells in Patient With Advanced Lymphoid Malignancies
Status: TERMINATED
Conditions: B-cell Acute Lymphoblastic Leukemia|Non-Hodgkin's Lymphoma, Relapsed|Non-Hodgkin's Lymphoma Refractory|Primary Mediastinal Large B Cell Lymphoma|Diffuse Large B Cell Lymphoma|Follicular Lymphoma|Mantle Cell Lymphoma|High-grade B-cell Lymphoma
Interventions: BIOLOGICAL: RPM CD19-mbIL15-CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serum Catestatin Expression and Cardiometabolic Parameters in Patients With Congestive Heart Failure
Status: COMPLETED
Conditions: Heart Failure，Congestive
Interventions: DIAGNOSTIC_TEST: Blood withdrawal for laboratory analysis|OTHER: Standard-of-care treatment|DIAGNOSTIC_TEST: Transthoracic echocardiography (TTE)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Antineoplaston Therapy in Treating Patients With Colon Cancer
Status: WITHDRAWN
Conditions: Stage IV Colon Cancer|Recurrent Colon Cancer|Adenocarcinoma of the Colon
Interventions: DRUG: antineoplaston A10|DRUG: antineoplaston AS2-1|PROCEDURE: alternative product therapy|PROCEDURE: biological therapy|PROCEDURE: biologically based therapies|PROCEDURE: cancer prevention intervention|PROCEDURE: complementary and alternative therapy|PROCEDURE: differentiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Virtual Reality in Orthopaedic Surgical Education: A Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Surgical Education|Virtual Reality|Orthopaedic Training
Interventions: DEVICE: Immersive virtual reality (IVR)|OTHER: Traditional hands on orthopaedic workshop group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of E-cigarettes (ECIGs) on Pulmonary Inflammation and Behavior in HIV Infected Smokers
Status: TERMINATED
Conditions: Lung Inflammation|HIV Seropositivity
Interventions: OTHER: ECIGS|BEHAVIORAL: mobile contingency management (mCM)|OTHER: Usual brand
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Myo-inositol in Women With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Resistance, Insulin|Glucose Intolerance
Interventions: DRUG: Myo-inositol|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DIETARY_SUPPLEMENT: calcitriol|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Trial of Nivolumab With Chemotherapy as Neoadjuvant Treatment in Inflammatory Breast Cancer (IBC)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Nivolumab 360mg|DRUG: Paclitaxel 80mg/m^2|DRUG: Doxorubicin 60mg/m^2|DRUG: Cyclophosphamide 600mg/m^2|DRUG: Paclitaxel 80mg/m^2 or Docetaxel 75mg/m^2|DRUG: Trastuzumab 8mg/kg and 6 mg/kg|DRUG: Pertuzumab 840mg and 420mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing
Status: RECRUITING
Conditions: Cleft Lip and Palate
Interventions: GENETIC: identification of genetic factors
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: S0308 Zoledronate or Ibandronate in Preventing Bone Problems in Women With Stage IV Breast Cancer That Has Spread to the Bone
Status: WITHDRAWN
Conditions: Breast Cancer|Hypercalcemia of Malignancy|Metastatic Cancer|Pain
Interventions: DRUG: ibandronate|DRUG: zoledronate|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Performance of the DePuy Low Contact Stress (LCS®) Complete Anterior-Posterior Glide (APG) Mobile Bearing Knee
Status: TERMINATED
Conditions: Osteoarthritis
Interventions: DEVICE: L.C.S. APG Knee Anterior Posterior Glide knee
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sensori-motor and Perceptual Functions of the PPC.
Status: RECRUITING
Conditions: Healthy Volunteers|Optic Ataxia
Interventions: BEHAVIORAL: point targets|BEHAVIORAL: tactile stimulation|BEHAVIORAL: visual images
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Patient-Directed Postoperative Opioid Prescribing for Gynecologic Surgery
Status: COMPLETED
Conditions: Gynecology|Surgery|Opioid Use
Interventions: DRUG: Physician directed opioid prescribing|DRUG: Patient directed opioid prescribing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial on Pancreatic Stent Tube in Pancreaticoduodenectomy
Status: COMPLETED
Conditions: Pancreatic Cancer|Bile Duct Cancer|Ampullary Cancer|Pancreatitis|Duodenal Cancer
Interventions: DEVICE: external drainage tube [polyethylene pancreatic drainage tube]|DEVICE: internal drainage tube [polyethylene pancreatic drainage tube]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention and Treatment of CINV Caused by TC Regimen in Gynecological Malignant Tumor Patients
Status: RECRUITING
Conditions: Gynecological Tumor
Interventions: DRUG: Aprepitant Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Genotype-directed Neoadjuvant Chemoradiation for Rectal Carcinoma
Status: COMPLETED
Conditions: Rectal Carcinoma
Interventions: DRUG: 5FU|RADIATION: Radiation|PROCEDURE: Surgery of resectable lesions|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Potency of Formoterol Novolizer® 12 µg Compared to Formoterol Aerolizer® 12 µg
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Formatris 24µg|DRUG: Formatris 12µg|DRUG: Foradil P 24µg|DRUG: Foradil P 12µg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of PEEP on TRJV in Mechanically Intubated Pediatric Patients
Status: RECRUITING
Conditions: Tricuspid Regurgitation|Mechanical Ventilation Pressure High|Pediatric Respiratory Diseases
Interventions: OTHER: Application of positive-end-expiratory pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 3B, Open-label, Single-arm Study of the Efficacy and Safety of Apremilast, in Subjects With Plaque Psoriasis That is Not Adequately Controlled by Topical Therapy
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Apremilast|DRUG: Topical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tislelizumab Combined With Chemotherapy Versus Chemotherapy Alone in Recurrent or Metastatic Nasopharyngeal Cancer
Status: COMPLETED
Conditions: Recurrent or Metastatic Nasopharyngeal Cancer
Interventions: DRUG: Tislelizumab|DRUG: Placebo|DRUG: Gemcitabin|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sensory-driven Motor Recovery in Poorly Recovered Subacute Stroke Patients
Status: COMPLETED
Conditions: Stroke|Cerebrovascular Accident
Interventions: DEVICE: S88 Dual Output Stimulator by Grass Technologies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Eribulin Mesylate With Trastuzumab for Advanced or Recurrent Human Epidermal Growth Factor Receptor 2-Positive (HER2+) Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: E7389
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Finding of Optimal Dose for NT 201 in the Treatment of Glabellar Frown Lines
Status: COMPLETED
Conditions: Glabellar Frown Lines
Interventions: DRUG: Botulinum neurotoxin type A, free of complexing proteins|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study To Compare Avelumab In Combination With Standard of Care Chemoradiotherapy (SoC CRT) Versus SoC CRT for Definitive Treatment In Patients With Locally Advanced Squamous Cell Carcinoma Of The Head And Neck (JAVELIN HEAD AND NECK 100)
Status: TERMINATED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Avelumab|OTHER: Chemoradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hospital Design and Risk of Nosocomial Infections: A Prospective Controlled Trial
Status: COMPLETED
Conditions: Vancomycin Resistant Enterococci Infection|Clostridium Difficile Infection|Nosocomial Infection|Methicillin Resistant Staphylococcus Aureus Infection (MRSA)
Interventions: OTHER: Admission to a novel hospital ward
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Creating a Zone of Openness to Increase Patient-Centered Care
Status: COMPLETED
Conditions: Patient Engagement|Physician's Role|Physician-Patient Relationship
Interventions: BEHAVIORAL: Ask 3 Questions|BEHAVIORAL: Open Communication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pregnancy in Polycystic Ovary Syndrome II
Status: COMPLETED
Conditions: Pregnancy|Polycystic Ovary Syndrome
Interventions: DRUG: Clomiphene citrate|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Supplementation With Alpha-lipoic Acid and Silybum Marianum(LUDLEV®) for the Improvement of Fatty Liver Disease
Status: RECRUITING
Conditions: Metabolic Associated Fatty Liver Disease
Interventions: DIETARY_SUPPLEMENT: LUDLEV®300 mg/46.2 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Eye-Movement Desensitization and Reprocessing in the ED and Post-Traumatic Syndrome
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: OTHER: Reassurance|OTHER: Eye-Movement Desensitization and Reprocessing (EMDR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Testing New Strategies for Patients Hospitalised With HIV-associated Disseminated Tuberculosis
Status: RECRUITING
Conditions: Disseminated Tuberculosis|HIV
Interventions: DRUG: Rifampin|DRUG: Levofloxacin|DRUG: Rifampicin, Pyrazinamide, Ethambutol and Isoniazid|DRUG: Prednisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone and Lower Extremity Block Duration
Status: TERMINATED
Conditions: Analgesia Duration
Interventions: DRUG: Dexamethasone|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Niacin on Endothelial Function in HIV-infected Subjects With Low High Density Lipoprotein Cholesterol Levels
Status: COMPLETED
Conditions: HIV Infections|Dyslipidemia|Endothelial Dysfunction
Interventions: DRUG: extended release niacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of a Vibrotactile Balance Belt System for Vestibular Rehabilitation in the Pediatric Population
Status: COMPLETED
Conditions: Vestibular Diseases
Interventions: DEVICE: Vestibular Rehabilitation/Balance Belt|OTHER: Standard Vestibular Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selumetinib Sulfate in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer With KRAS G12R Mutations
Status: COMPLETED
Conditions: KRAS NP_004976.2:p.G12R|Stage III Pancreatic Cancer AJCC v6 and v7|Stage IV Pancreatic Cancer AJCC v6 and v7
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Selumetinib Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Percutaneous Transluminal Angioplasty in Diabetic Foot Syndrome (PTA-DFS)
Status: RECRUITING
Conditions: Diabetic Foot|Diabetes Mellitus|Peripheral Arterial Disease|Diabetic Neuropathies|Diabetic Retinopathy|Anemia|Ulcer Foot|Ulcer Ischemic|Diabetic Polyneuropathy
Interventions: PROCEDURE: percutaneous transluminal angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PROTECT-APT 1: Early Treatment and Post-Exposure Prophylaxis of COVID-19
Status: RECRUITING
Conditions: SARS-CoV-2
Interventions: DRUG: Upamostat|DRUG: Placebo (PO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Immune Checkpoint Inhibitor M7824 and the Immunocytokine M9241 in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Advanced Pancreas Cancer
Status: TERMINATED
Conditions: Histologically or Cytologically Confirmed Pancreatic Cancer|Unresectable or Borderline Resectable Pancreatic Cancer|Pancreatic Neoplasms|Pancreatic Cancer|Metastatic Pancreatic Cancer
Interventions: DRUG: M7824|DRUG: M9241|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HR-lowering Efficacy and Respiratory Safety of Ivabradine in Patients With Obstructive Airway Disease
Status: COMPLETED
Conditions: Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Ivabradine (Procoralan)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Visual Outcomes After Implantation of the POD AY GF F (PhysIOL) and the POD AY 26P F (PhysIOL)
Status: COMPLETED
Conditions: Cataract|Lens Opacity
Interventions: DEVICE: IOL implantation experimental|DEVICE: IOL implantation comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Effectiveness and Safety of Risdiplam Administered as an Early Intervention in Pediatric Participants With Spinal Muscular Atrophy After Gene Therapy
Status: RECRUITING
Conditions: Muscular Atrophy, Spinal
Interventions: DRUG: risdiplam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CAPITAL DOREMI 2: Inotrope Versus Placebo Therapy for Cardiogenic Shock
Status: RECRUITING
Conditions: Shock, Cardiogenic
Interventions: DRUG: Dobutamine|DRUG: Milrinone|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating AHB-137 in Healthy Participants and Participants With Chronic Hepatitis B
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Hepatitis B
Interventions: DRUG: AHB-137 injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Troxatyl™ Administered by Continuous Infusion to Subjects With Solid Tumors
Status: TERMINATED
Conditions: Neoplasms
Interventions: DRUG: Troxatyl™ (Cytotoxic Chemotherapeutic)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Study of Lithium Plus Extended-Release Carbamazepine (ERC-CBZ) for Rapid Cycling Bipolar Disorder
Status: UNKNOWN
Conditions: Bipolar Disorder
Interventions: DRUG: Lithium Plus Extended- Release Carbamazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CART19 Cells Treatment of MRD of B Cell Malignancies and Then Auto-HSCT
Status: UNKNOWN
Conditions: Leukemia, Lymphocytic, Acute, B-Cell|Leukemia, Lymphocytic, Chronic, B-Cell|Lymphoma, B-Cell
Interventions: BIOLOGICAL: CART19 cell and auto-HSCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Acupuncture and Pain Medication on Radicular Pain Using QST
Status: COMPLETED
Conditions: Pain
Interventions: OTHER: Acupuncture|OTHER: Sham Acupuncture|DRUG: Gabapentin|DRUG: Sham Gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: S0205 Gemcitabine w/ or w/o Cetuximab as First-Line Therapy in Locally Advanced Pancreas Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CAMPFIRE: A Study of Abemaciclib (LY2835219) in Participants With Ewing's Sarcoma
Status: RECRUITING
Conditions: Sarcoma, Ewing|Neoplasm Metastasis
Interventions: DRUG: Abemaciclib|DRUG: Irinotecan|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of a Booster Dose of the Investigational CV0501 mRNA COVID-19 Vaccine in Adults at Least 18 Years Old
Status: COMPLETED
Conditions: COVID-19|SARS-CoV-2
Interventions: BIOLOGICAL: CV0501 (3 μg)|BIOLOGICAL: CV0501 (6 μg)|BIOLOGICAL: CV0501 (12 μg)|BIOLOGICAL: CV0501 (25 μg)|BIOLOGICAL: CV0501 (50 μg)|BIOLOGICAL: CV0501 (75 μg)|BIOLOGICAL: CV0501 (100 μg)|BIOLOGICAL: CV0501 (150 μg)|BIOLOGICAL: CV0501 (200 μg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Using Autologous Platelet Rich Plasma (PRP) Gel to Treat Deep 2nd and 3rd Degree Burns
Status: UNKNOWN
Conditions: Acute Burns
Interventions: DEVICE: Magellan®|OTHER: Placebo Saline Gel and Usual and Customary Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CMV-specific T Cell Immunity Test Indicated Prophylaxis of Letermovir After All-HSCT
Status: NOT_YET_RECRUITING
Conditions: Hematologic Malignancy
Interventions: DRUG: Letermovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Phosphorus Additives on the Metabolome in Healthy Adults
Status: COMPLETED
Conditions: Metabolic Syndrome|Insulin Sensitivity|Cardiovascular Diseases
Interventions: OTHER: Phosphorus-supplemented study diet|OTHER: Control Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Protocol of a Pilot Study to Optimize Care for Heart Failure Patients in Primary Care
Status: COMPLETED
Conditions: Heart Failure
Interventions: DEVICE: Cobas h232 (Roche Diagnostics)|OTHER: Clinical audit and feedback|OTHER: Assistance by a specialized HF nurse
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Regadenoson Blood Flow in Type 1 Diabetes (RABIT1D)
Status: COMPLETED
Conditions: Coronary Artery Disease|Type 1 Diabetes Mellitus
Interventions: DRUG: Regadenoson myocardial perfusion imaging|DRUG: Regadenoson MRI myocardial blood flow
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Lactobacillus Delbrueckii Subsp. Bulgaricus on Human's Weight Reduction
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: Probiotics|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Collaborative Care to Alleviate Symptoms and Adjust to Illness in Chronic Heart Failure (CASA) Trial
Status: COMPLETED
Conditions: Chronic Heart Failure
Interventions: OTHER: CASA Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Placebo|DRUG: Tozorakimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Chemotherapy Compared To Neoadjuvant Chemoradiation in Patients With Adenocarcinoma of the Esophagus
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Adenocarcinoma (UICC TNM7)|Adenocarcinoma of the Esophagogastric Junction
Interventions: DRUG: 5-Fluorouracil|DRUG: Leucovorin|DRUG: Oxaliplatin|DRUG: Docetaxel|DRUG: Carboplatin|DRUG: Paclitaxel|RADIATION: Neoadjuvant radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pregnancy in GUCH Patients
Status: NOT_YET_RECRUITING
Conditions: Congenital Heart Disease|Pregnancy Related|Infant Development|IUGR|Fetal Growth Restriction
Interventions: DIAGNOSTIC_TEST: Neurodevelopmental assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rituximab, Eltrombopag and Dexamethasone as Frontline Treatment for Immune Thrombocytopenia
Status: UNKNOWN
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Rituximab|DRUG: Eltrombopag|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Treatment of Herpes Simplex Encephalitis (HSE) With Valacyclovir
Status: COMPLETED
Conditions: Encephalitis
Interventions: DRUG: Valacyclovir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Graft Versus Flap in Management of Proximal Penile Hypospadias
Status: RECRUITING
Conditions: Proximal Penile Hypospadias
Interventions: PROCEDURE: inner preputial graft versus transverse preputial island flap in two-stage repair of proximal penile hypospadias
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: EXtended CriteriA Treatment for LIver Metastases and Heavy Tumour BURden
Status: RECRUITING
Conditions: Liver Metastases|Colorectal Cancer
Interventions: PROCEDURE: Liver-resection or ablation|DRUG: 2nd line chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Lateral Ridge Augmentation Using Two Graft Combination and a Cross-linked Collagen Membrane
Status: COMPLETED
Conditions: Alveolar Bone Resorption
Interventions: PROCEDURE: Guided bone regeneration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dry Needling of the Trapezius Muscle in Office Workers With Neck Pain
Status: COMPLETED
Conditions: Myofascial Trigger Point Pain
Interventions: OTHER: Group 1. Deep dry needling|OTHER: group 2. Passive analitical stretch (performed in both groups)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose FSH-GEX™ in Healthy Volunteers
Status: COMPLETED
Conditions: Female Infertility
Interventions: DRUG: FSH-GEX™|DRUG: Gonal-f|DRUG: Bravelle|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effects of the Digital App Rheumabuddy4.1 in a Clinical Set-up in Patients With Rheumatoid Arthritis
Status: NOT_YET_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DEVICE: Digital app RB4.1|OTHER: Control arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Relapse Prevention in Alcohol Dependency by Transcranial Direct Current Stimulation Supported Cue Exposure Therapy
Status: UNKNOWN
Conditions: Alcohol Dependency
Interventions: DEVICE: tDCS|BEHAVIORAL: Cue Exposure Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Restorative Treatment in First Molars Affected by Molar-Incisor Hypomineralization
Status: COMPLETED
Conditions: Molar Incisor Hypomineralization
Interventions: PROCEDURE: restorative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Benign Paroxysmal Positional Vertigo (BPPV) Training for Sports Medicine Providers in a Pediatric Concussion Program
Status: COMPLETED
Conditions: Benign Paroxysmal Positional Vertigo
Interventions: BEHAVIORAL: Diagnostic training|BEHAVIORAL: Diagnostic and treatment training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Defining the Clinical Role of Topiramate in the Treatment of Alcohol Dependence in Australia
Status: UNKNOWN
Conditions: Alcohol Dependence
Interventions: DRUG: Topiramate|DRUG: Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Stage IV Locally Advanced or Metastatic Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: cisplatin|DRUG: docetaxel|DRUG: gemcitabine hydrochloride|DRUG: methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neural Adaptations to Metronome-Paced Strength Training
Status: RECRUITING
Conditions: Healthy
Interventions: OTHER: Fractal Paced|OTHER: Isochronous Paced|OTHER: Self Paced
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of a Scapular-focused Exercise Protocol
Status: COMPLETED
Conditions: Rotator Cuff Syndrome of Shoulder and Allied Disorders
Interventions: OTHER: Scapular-focused exercise protocol with EMGBF|OTHER: Control Therapy|OTHER: Scapular-focused exercise protocol without EMGBF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: 24-week Treatment With Lixisenatide in Type 2 Diabetes Insufficiently Controlled With Metformin and Insulin Glargine
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Lixisenatide (AVE0010)|DRUG: Placebo|DRUG: Insulin glargine|DEVICE: Pen auto-injector|DRUG: Metformin|DRUG: Thiazolidinedione (TZD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ustekinumab (STELARA®) in Adult Japanese Participants With Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: Ustekinumab|DRUG: Placebo|OTHER: Concomitant topical medications for atopic dermatitis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glioblastoma Multiforme (GBM) Locoregional Agent Survival Study - Anti-tenascin Radiolabeled Antibody Therapy
Status: TERMINATED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Neuradiab + Radiotherapy + Temozolomide|DRUG: Radiation Therapy + Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Omega 5 Fatty Acid as an Adyuvant Treatment to Prednisone in Patients With Severe Alcoholic Hepatitis
Status: COMPLETED
Conditions: Alcoholic Hepatitis
Interventions: DIETARY_SUPPLEMENT: Omega 5 fatty acid supplement|OTHER: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pulse Electromagnetic Field Therapy (PEMF) in Patients With Nonspecific Chronic Neck Pain
Status: COMPLETED
Conditions: Neck Pain|Musculoskeletal Diseases|Chronic Neck Pain|Cervical Disc Disease
Interventions: OTHER: Pulse electromagnetic field therapy|OTHER: Sham pulse electromagnetic field therapy|OTHER: Therapeutic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Changes of Angle Kappa After Implantation of Multifocal Intraocular Lenses
Status: COMPLETED
Conditions: Cataract|Presbyopia
Interventions: PROCEDURE: cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Letermovir Treatment in Pediatric Participants Following Allogeneic Haematopoietic Stem Cell Transplantation (HSCT) (MK-8228-030)
Status: COMPLETED
Conditions: Cytomegalovirus (CMV) Infection
Interventions: DRUG: Letermovir oral granules|DRUG: Letermovir tablet|DRUG: Letermovir intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial to Investigate Different Doses of Lonapegsomatropin Compared to Somatropin in Individuals With Turner Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Turner Syndrome
Interventions: BIOLOGICAL: Lonapegsomatropin|DRUG: Somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pomegranate Juice in the Modulation of Oxidative Stress Markers in Endurance-based Athletes
Status: COMPLETED
Conditions: Oxidative Stress
Interventions: DIETARY_SUPPLEMENT: Pomegranate juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reinforcement of Abstinence and Continuing Care in Substance Abuse Treatment
Status: COMPLETED
Conditions: Substance Use Disorders|Alcohol Abuse|Alcoholism|Substance Dependence|Substance Abuse
Interventions: BEHAVIORAL: Contracting, Prompting and Reinforcement arm|BEHAVIORAL: Control arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of Ensifentrine in Patients With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Ensifentrine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modified ORS Solution for Severely Malnourished Children
Status: COMPLETED
Conditions: Malnourished Children With Watery Diarrhoea
Interventions: OTHER: Modified ORS-1|OTHER: Modified ORS-2 (ReSoMal)|OTHER: Modified ORS-3 (Benefibre)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study for Patients With Relapsing Remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: dirucotide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency in Differentiated Thyroid Cancer Metastatic Lymph Node: Prospective Study of Safety and Efficacy
Status: UNKNOWN
Conditions: Differentiated Thyroid Cancer
Interventions: DEVICE: Radiofrequency (RF star electrode electrode_Fixed)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity
Status: RECRUITING
Conditions: Parkinson|Cerebellar Tumor|Rest Tremor|Diagnoses Disease|Movement; Abnormal, Involuntary
Interventions: DIAGNOSTIC_TEST: EMG in wrist flexor-pronators and extensor-supinators
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enhancing Teachable Moment Communication for Smoking Cessation and Weight Management
Status: COMPLETED
Conditions: Clinician Patient Communication|Smoking Cessation|Weight Management
Interventions: OTHER: Teachable Moment Communication Process
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Pharmacokinetics and Safety Between Single Administration of "BR6002" and Coadministration of "BR6002A" and "BR6002B" Under Fasting Conditions in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Gastric or Duodenal Ulcers
Interventions: DRUG: BR6002A|DRUG: BR6002B|DRUG: BR6002
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pyrocardan® Implant Arthroplasty or LRTI for Trapeziometacarpal Osteoarthritis
Status: RECRUITING
Conditions: CMC-1 Osteoarthritis|Trapeziometacarpal Osteoarthritis
Interventions: PROCEDURE: Pyrocardan® implant|PROCEDURE: Ligament reconstruction and tendon interposition (LRTI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methicillin-sensitive and Methicillin-resistant Staphylococcus Aureus (MSSA/MRSA) - Point-of-care-testing (POCT) in Clinical Decision Making
Status: UNKNOWN
Conditions: Staphylococcus Aureus
Interventions: OTHER: Decolonization by nasal Octinidin treatment and skin washings
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sustainable Upscaling of Depression Prevention
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Moodbuster Life|BEHAVIORAL: Mobile application|BEHAVIORAL: Guidance by a coach|BEHAVIORAL: Motivational Content
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study on BI 54903 (Inhaled Corticosteroid) Administered Once Daily or Twice Daily Via Respimat Inhaler in Patients With Asthma Inadequately Controlled on Short Acting Beta-2 Agonist (SABA) Therapy Alone
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: BI 54903 MD|DRUG: Placebo matching Respimat|DRUG: Placebo matching Respimat|DRUG: BI 54903
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Multi-center Open-label Phase 2 Study of Ixazomib, Iberdomide and Dexamethasone in Elderly Patients With Multiple Myeloma at First Relapse."
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma at First Relapse
Interventions: DRUG: Ixazomib|DRUG: Iberdomide|DRUG: Dexamethasone Oral
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraocular Pressure Reduction Efficacy of Rhopressa and Lumigan in Normal Tension Glaucoma
Status: UNKNOWN
Conditions: Normal Tension Glaucoma
Interventions: DRUG: Netarsudil Ophthalmic|DRUG: Bimatoprost Ophthalmic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antiandrogen Therapy and Radiation Therapy With or Without Docetaxel in Treating Patients With Prostate Cancer That Has Been Removed by Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage I Prostate Adenocarcinoma AJCC v7|Stage II Prostate Adenocarcinoma AJCC v7|Stage III Prostate Adenocarcinoma AJCC v7
Interventions: DRUG: Bicalutamide|DRUG: Degarelix|DRUG: Docetaxel|RADIATION: External Beam Radiation Therapy|DRUG: Flutamide|DRUG: Goserelin|DRUG: Goserelin Acetate|OTHER: Laboratory Biomarker Analysis|DRUG: Leuprolide|DRUG: Leuprolide Acetate|DRUG: Nilutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bifurcation Stenting Using 2 Link Stent Nobori Versus 3 Link Stent Xience
Status: UNKNOWN
Conditions: Coronary Stenosis
Interventions: DEVICE: Bifurcation stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Ashwagandha (Withania Somnifera) Supplementation on Exercise Performance in Female Footballers
Status: COMPLETED
Conditions: Muscle Strength
Interventions: DIETARY_SUPPLEMENT: Ashwagandha|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE