pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy
Status: RECRUITING
Conditions: Systolic Hypertension|Pregnancy Related|Diastolic Hypertension|Cardiac Output, Low|Cardiac Output, High
Interventions: DRUG: Labetalol|DRUG: Atenolol|DRUG: Nifedipine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Effectiveness of Venetoclax in Combination With Azacitidine or Decitabine in an Outpatient Setting in Patients With Acute Myeloid Leukemia (AML) Ineligible for Intensive Chemotherapy
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)|Cancer
Interventions: DRUG: Venetoclax|DRUG: Azacitidine|DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase IIa Study of the MEK Inhibitor Trametinib Monotherapy in the Treatment of Biliary Tract Cancers
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Trametinib (single tablet)|DRUG: Trametinib (Multiple tablet)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Salmeterol on Walking Capacity in Patients With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Placebo|DRUG: Salmeterol diskus inhalation powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Screening Algorithms for Cervical and Anal High-Grade Squamous Intraepithelial Lesions in People With HIV in Mexico and Puerto Rico
Status: RECRUITING
Conditions: AIDS-Related Anal Carcinoma|AIDS-Related Cervical Carcinoma|High Grade Anal Intraepithelial Neoplasia|High Grade Cervical Intraepithelial Neoplasia|HIV Infection
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection - Anal|PROCEDURE: Biospecimen Collection - Cervical|PROCEDURE: Colposcopy|PROCEDURE: High Resolution Anoscopy|PROCEDURE: Imaging Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Anemia Treatment for Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Receiving Chemotherapy
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer|Anemia|Cancer|Lung Cancer
Interventions: DRUG: Darbepoetin alfa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Adoptive Cellular Therapy Using Autologous T Cells Transduced With Lentivirus to Express a CD33 Specific Chimeric Antigen Receptor in Patients With Relapsed or Refractory CD33-Positive Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Hematopoietic/Lymphoid Cancer|Acute Myeloid Leukemia
Interventions: PROCEDURE: Leukapheresis|DRUG: Fludarabine|DRUG: Cyclophosphamide|BIOLOGICAL: CD33-CAR-T Cell Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Candesartan as a Treatment for Cocaine Dependence
Status: TERMINATED
Conditions: Cocaine Dependence
Interventions: DRUG: Candesartan with CBT|OTHER: Placebo with CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Qutenza (8% Capsaicin) With a Low-dose Capsaicin for Treatment of Nerve Pain After Surgery
Status: RECRUITING
Conditions: Post Surgical Neuropathic Pain
Interventions: DRUG: Qutenza (capsaicin) 8% topical system|DRUG: capsaicin 0.04% topical system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Elastic Tape on Activation of the Quadriceps Muscle During Selected Resisted and Weight Bearing Exercises
Status: COMPLETED
Conditions: Healthy Subjects|Changes Based on Duration of Tape Application|Direction of Kinesio Tape Application
Interventions: DEVICE: Kinesio Tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Injection Pressure on Myocardial Reperfusion During Primary PCI
Status: COMPLETED
Conditions: Myocardial Reperfusion|STEMI - ST Elevation Myocardial Infarction
Interventions: OTHER: Use of different injection pressure during primary PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnosis of ON With or Without MS or NMOSD
Status: TERMINATED
Conditions: Multiple Sclerosis|Neuromyelitis Optica Spectrum Disorder Attack|Neuromyelitis Optica Spectrum Disorder Relapse|Neuromyelitis Optica Spectrum Disorder Progression|Optic Neuritis
Interventions: DIAGNOSTIC_TEST: Reflex (Brightlamp Inc., Purdue University)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Diffusion MRI; Predictive Value for Cervical Uterine Cancer Recurrence
Status: UNKNOWN
Conditions: Uterine Cervical Cancer|Diffusion-weighted MRI|Recurrence
Interventions: PROCEDURE: Diffusion weighted MRI (DW- MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Body Composition and Exercise on Clinical, Metabolic and Molecular Parameters in Type 2 Diabetics in Qatar
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: 10-week exercise programme based on aerobic interval and resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of S-8184 in Second Line Treatment of Relapsed Stage IIIB or IV Non Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: S-8184 Paclitaxel Injectable Emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GLP-1 Inhibits Prandial Antro-duodeno-jejunal Motility in Humans
Status: COMPLETED
Conditions: Functional Gastrointestinal Disorders
Interventions: BIOLOGICAL: GLP-1|BIOLOGICAL: Intravenous saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The EFfect of FinErenone in Kidney TransplantiOn Recipients: The EFFEKTOR Study
Status: RECRUITING
Conditions: Kidney Transplant; Complications
Interventions: DRUG: Finerenone Oral Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Solo Single Incision Laparoscopic Cholecystectomy
Status: UNKNOWN
Conditions: Cholecystectomy, Laparoscopic
Interventions: PROCEDURE: Solo surgery|PROCEDURE: operation with a camera operator in SILC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Implementation of eScreening in Post 9/11 Transition Programs
Status: ACTIVE_NOT_RECRUITING
Conditions: Depression|Stress Disorders, Post-Traumatic|Suicide
Interventions: OTHER: Multicomponent Implementation Strategy|OTHER: eScreening
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy Study of Viokase® 16 for the Correction of Steatorrhea
Status: COMPLETED
Conditions: Exocrine Pancreatic Insufficiency|Chronic Pancreatitis|Pancreatectomy
Interventions: DRUG: Viokase® 16|DRUG: Placebo|DRUG: Proton pump inhibitor (PPI)|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Support With Perhexiline to Protect Myocardium Undergoing Coronary Artery Surgery
Status: COMPLETED
Conditions: Myocardial Reperfusion Injury|Cardiac Output, Low
Interventions: DRUG: Perhexiline|DRUG: Placebo marked PEXSIG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of L. Reuteri on Bowel Movements in Children (BIOWELL Study)
Status: COMPLETED
Conditions: Constipation
Interventions: DIETARY_SUPPLEMENT: L.reuteri|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the User Performance and Experience of Nucleus Pen vs. Commercially Available Pen Needle
Status: COMPLETED
Conditions: Diabetes
Interventions: DEVICE: BD Nano™ vs Nucleus|DEVICE: NovoFine® vs Nucleus|DEVICE: NovoTwist®/NovoFine® Plus vs Nucleus|DEVICE: Other Commercially Available Pen Needles (Unifine® Pentips®/Mylife Clickfine®) vs Nucleus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study To Learn About Two Study Medicines (PF-07275315 And PF-07264660) In People Who Have Moderate To Severe Atopic Dermatitis
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: PF-07275315|DRUG: PF-07264660|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postpartum Oxytocin Administration in the Era of Delayed Cord Clamping
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: OTHER: Initiation of standard postpartum oxytocin immediately following fetal shoulder delivery|OTHER: Initiation of standard postpartum oxytocin immediately following placenta delivery|OTHER: Saline Placebo|OTHER: Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Cryopneumatic Device After Shoulder Surgeries
Status: COMPLETED
Conditions: Shoulder Injuries|Shoulder Disease
Interventions: DEVICE: Game Ready ATX shoulder wrap; Game Ready GRPro 2.1|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Reslizumab (0.3 or 3.0 mg/kg) as Treatment for Patients (12-75 Years of Age) With Eosinophilic Asthma
Status: COMPLETED
Conditions: Eosinophilic Asthma
Interventions: DRUG: Reslizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Post-operative Treatment of Diabetic Peripheral Arterial Disease Guided by Platelet Reactivity Unit
Status: UNKNOWN
Conditions: Peripheral Artery Disease
Interventions: OTHER: platelet (P2Y12) reaction units|DRUG: ticagrelor|DRUG: Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Group Medical Visits for Latina Women With Urgency Urinary Incontinence
Status: TERMINATED
Conditions: Overactive Bladder|Urinary Urgency|Urge Incontinence
Interventions: OTHER: Group Medical Visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A First-in-human Study to Learn How Safe the Study Treatment BAY2862789 is, to Find the Best Dose, How it Affects the Body, What Maximum Amount Can be Given, How it Moves Into, Through and Out of the Body, and How it Acts on Different Tumors in Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors|Non-small Cell Lung Cancer
Interventions: DRUG: BAY2862789
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically-Modified Neural Stem Cells Expressing E.Coli Cytosine Deaminase for Treatment of Recurrent High Grade Gliomas
Status: COMPLETED
Conditions: Adult Anaplastic Astrocytoma|Recurrent Grade III Glioma|Recurrent Grade IV Glioma|Adult Anaplastic Oligodendroglioma|Adult Brain Tumor|Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Adult Mixed Glioma|Recurrent Adult Brain Tumor|Adult Anaplastic Oligoastrocytoma|Recurrent High Grade Glioma
Interventions: DRUG: flucytosine|OTHER: polymerase chain reaction|OTHER: immunohistochemistry staining method|BIOLOGICAL: gene therapy|OTHER: pharmacological study|OTHER: 3-Tesla magnetic resonance imaging|OTHER: laboratory biomarker analysis|PROCEDURE: therapeutic conventional surgery|BIOLOGICAL: E. coli CD-expressing genetically modified neural stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Cortisol on Heroin Craving in Opioid Dependence (Ghost-Basel)
Status: COMPLETED
Conditions: Opioid Dependence
Interventions: DRUG: Cortisol 20 mg|DRUG: Mannitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound vs Palpation for Radial Artery Cannulation
Status: COMPLETED
Conditions: Obese
Interventions: PROCEDURE: Ultrasound -guided cannulation|PROCEDURE: Palpation -guided cannulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Back Pain Prevention in Multiple Myeloma Using an External Spinal Brace
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DEVICE: thoracolumbosacral orthosis or cervicothoracolumbar orthosis|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long-Term Safety And Tolerability Extension Study Of Bapineuzumab In Alzheimer Disease Patients
Status: TERMINATED
Conditions: Alzheimer Disease
Interventions: DRUG: Bapineuzumab 0.5 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study Comparing AM001 Cream, 7.5% to Vehicle Cream in the Treatment of Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: AM001 Cream, 7.5%|DRUG: Vehicle Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Piribedil (Clarium®) on Vigilance and Cognitive Function in Patients With Parkinson's Disease Compared to Other Non-Ergot Dopamine Agonists
Status: COMPLETED
Conditions: Idiopathic Parkinson's Disease
Interventions: DRUG: piribedil|DRUG: pramipexole or ropinirole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Abdomen CT and Open Appendicectomy：New Diagnostic and Surgical Procedures
Status: COMPLETED
Conditions: Wound Infection|Complication|Scar
Interventions: RADIATION: The application of abdomen CT|OTHER: traditional incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Pain, Acceptance, and Discomfort With Periodontally Accelerated Osteogenic Orthodontics (PAOO)
Status: COMPLETED
Conditions: Crowding of Anterior Mandibular Teeth
Interventions: PROCEDURE: Periodontally Accelerated Osteogenic Orthodontics (PAOO)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of AK117/AK112 in Metastatic Triple-Negative Breast Cancer
Status: UNKNOWN
Conditions: Metastatic Triple-negative Breast Cancer|Locally Advanced Triple-negative Breast Cancer
Interventions: DRUG: AK117|DRUG: AK112|DRUG: Nab paclitaxel|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prognostic Value of Circulating Tumoral DNA After the First 6 Months of Treatment in Patients With Waldenström Macroglobulinemia
Status: WITHDRAWN
Conditions: Waldenstrom's Disease|Waldenstrom Macroglobulinemia
Interventions: BIOLOGICAL: bone marrow sample|BIOLOGICAL: blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Decitabine, Donor Natural Killer Cells, and Aldesleukin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Recurrent Adult Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia
Interventions: DRUG: decitabine|BIOLOGICAL: natural killer cell therapy|BIOLOGICAL: aldesleukin|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platform-based Mild Cognitive Impairment (MCI) Trial
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Planning for the Future|BEHAVIORAL: Enhanced Medical Engagement|BEHAVIORAL: Confidence Building and Social Engagement|BEHAVIORAL: Physical Intervention|BEHAVIORAL: Medical Adherence
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Homoharringtonine in Treating Patients With Chronic Phase Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Childhood Chronic Myelogenous Leukemia|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Chronic Phase Chronic Myelogenous Leukemia|Relapsing Chronic Myelogenous Leukemia
Interventions: DRUG: omacetaxine mepesuccinate|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Gender on Interaction of Propofol and Dexmedetomidine
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: 0.0 ng/ml Dexmedetomidine|DRUG: 0.4 ng/ml Dexmedetomidine|DRUG: 0.6 ng/ml Dexmedetomidine|DRUG: 0.8 ng/ml Dexmedetomidine|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study Evaluating the Efficacy and Safety of Timolol Ophthalmic Solution as an Acute Treatment of Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Timolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial for the Treatment of Carbapenem Resistant Gram-negative Bacterial Infection With Colistimethate Sodium for Injection
Status: RECRUITING
Conditions: Mental Health Issue
Interventions: DRUG: Colistimethate sodium for injection|DRUG: Meropenem for Injection|DRUG: Coly Mycin M Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Timing Evaluation of Stoma Closure (TIMES). Early vs Late Closure of Stoma After Rectal Cancer Surgery.
Status: RECRUITING
Conditions: Rectal Cancer|Total Mesorectal Excision|Ileostomy - Stoma|Ileostomy; Complications|Ileostomy Closure
Interventions: PROCEDURE: Stoma closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of RO7049389 on the Pharmacokinetics of Pitavastatin in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: RO7049389|DRUG: Pitavastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydrocortisone Ophthalmic Ointment 0.5% for Treatment of Allergic Conjunctivitis
Status: TERMINATED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: hydrocortisone ophthalmic ointment 0.5%|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic-pharmacodynamic Interaction Between BIA 3-202 and Levodopa/Carbidopa
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: BIA 3-202|DRUG: Placebo|DRUG: Sinemet®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnosis of Pathological Complete Response by Vacuum-assisted Biopsy After Neoadjuvant Chemotherapy in Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DEVICE: Vacuum-Assisted Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Temporary vs.Long Term Hemodialysis Catheter on Central Vein Stenosis
Status: UNKNOWN
Conditions: Stenosis of Arteriovenous Dialysis Fistula
Interventions: DEVICE: temporary hemodialysis catheters|DEVICE: long-term hemodialysis catheters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Determine the Safety of BTP-114 for Treatment in Patients With Advanced Solid Tumors With BRCA Mutations
Status: UNKNOWN
Conditions: Pancreatic Neoplasms|Ovarian Neoplasms|Breast Neoplasms|Prostatic Neoplasms
Interventions: DRUG: BTP-114
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Pelacarsen on Patients After Myocardial Infarction With High Lp(a) Values (PEMILA)
Status: WITHDRAWN
Conditions: Acute Coronary Syndrome|Lipoproteinemia|Inflammation|Genetic Polymorphisms
Interventions: DRUG: Pelacarsen (TQJ230)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of NGAL and Cystatin C in Prediction of Acute Kidney Injury Covid-19 Infection
Status: COMPLETED
Conditions: Biochemical Markers ,NGAL,Cystatin c, Acute Kidneyinjury, Covid 19
Interventions: DIAGNOSTIC_TEST: serum NGAL and cystatin c
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open Label Study to Assess the Effect of Patient Use and Robustness of Tiotropium 18ug Inhalation Powder, Hard Capsule,Zephir Inhaler Device
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Tiotropium 18 µg inhalation powder, hard capsule|DEVICE: Zephir inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: QUILT-3.047: NANT Head and Neck Squamous Cell Carcinoma (HNSCC) Vaccine: Combination Immunotherapy in Subjects With HNSCC Who Have Progressed on or After Chemotherapy and PD-1/PD-L1 Therapy
Status: WITHDRAWN
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: BIOLOGICAL: Avelumab|BIOLOGICAL: Bevacizumab|DRUG: Capecitabine|BIOLOGICAL: Cetuximab|DRUG: Cisplatin|DRUG: cyclophosphamide|DRUG: 5-Fluorouracil (5-FU)|DRUG: fulvestrant|DRUG: leucovorin|DRUG: nab-paclitaxel|BIOLOGICAL: nivolumab|DRUG: Lovaza|RADIATION: Stereotactic Body Radiation Therapy|BIOLOGICAL: ALT-803|BIOLOGICAL: ETBX-011|BIOLOGICAL: ETBX-021|BIOLOGICAL: ETBX-051|BIOLOGICAL: ETBX-061|BIOLOGICAL: GI-4000|BIOLOGICAL: GI-6207|BIOLOGICAL: GI-6301|BIOLOGICAL: haNK
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pemetrexed+Platinum Chemotherapy With or Without Cosibelimab (CK-301) in First Line Metastatic Non-squamous Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Metastatic Non-squamous Non Small Cell Lung Cancer
Interventions: DRUG: Cosibelimab|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Pemetrexed|DIETARY_SUPPLEMENT: Folic acid 350-1000 μg|DIETARY_SUPPLEMENT: Vitamin B12 1000 μg|DRUG: Dexamethasone 4mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Computers to Assist in the Diagnosis and Treatment of Attention-deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: OTHER: CHICA ADHD Module
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of a Spine Navigation System on Op-time and Radiation Exposure
Status: WITHDRAWN
Conditions: Spinal Stenosis|Scoliosis|Spondylolisthesis
Interventions: DEVICE: Machine-vision Image Guided Surgery (MvIGS) spine navigation system.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Nivolumab in Pediatric Patients With Hypermutant Cancers
Status: TERMINATED
Conditions: Refractory or Recurrent Hypermutated Malignancies|Biallelic Mismatch Repair Deficiency (bMMRD) Positive Patients
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of ENGBD and PTGBD in Acute Suppurative Cholecystitis
Status: COMPLETED
Conditions: Success Rate
Interventions: PROCEDURE: Endoscopic naso-gallbladder drainage|PROCEDURE: Percutaneous gallbladder drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cryoablation Effects on Acute and Chronic Pain After Thoracotomy and Thoracoscopy
Status: RECRUITING
Conditions: Pain, Postoperative|Intrathoracic Procedure
Interventions: DEVICE: Atricure's crysoSPHERE probe|PROCEDURE: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study Assessing the Effect of Chocolate Consumption in Subjects With A History of Acne Vulgaris
Status: TERMINATED
Conditions: Acne
Interventions: DIETARY_SUPPLEMENT: 100% cocoa powder|DIETARY_SUPPLEMENT: gelatin (Gelita)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 1 Study in Patients With Relapsed or Refractory Hodgkin Lymphoma or Systemic Anaplastic Large Cell Lymphoma
Status: COMPLETED
Conditions: Hodgkin Lymphoma|Anaplastic Large-cell Lymphoma
Interventions: DRUG: brentuximab vedotin|DRUG: Brentuximab vedotin and rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Xylooligosarcharide on Composition of the Human Colonic Microflora
Status: COMPLETED
Conditions: Bifidobacteria|Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Placebo (Maltodextrin)|DIETARY_SUPPLEMENT: Xylooligosarcharide 1.4g|DIETARY_SUPPLEMENT: Xylooligosarcharide 2.8g
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Monitoring of Measles-specific Immune Status in Adult Allogeneic Hematopoietic Stem Cell Transplant Recipients
Status: RECRUITING
Conditions: Transplantation, Hematopoietic Stem Cell
Interventions: BIOLOGICAL: Biological samples (blood and oral fluid)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Tegoprazan and Minocycline Dual Therapy for Helicobacter Pylori Initial Treatment
Status: NOT_YET_RECRUITING
Conditions: Helicobacter Pylori Infection Chronic Gastrit
Interventions: DRUG: tegoprazan|DRUG: Minocycline|DRUG: bismuth potassium citrate|DRUG: Esomeprazole 40mg|DRUG: Amoxicillin|DRUG: clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mirabegron 25 mg for Treatment of Primary Nocturnal Enuresis
Status: RECRUITING
Conditions: Nocturnal Enuresis
Interventions: DRUG: desmopressin 120 mcg oral tablets|DRUG: Mirabegron 25 MG Oral Tablet, Extended Release|BEHAVIORAL: behavioral therapy alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient and Provider Assessment of Lipid Management Registry
Status: COMPLETED
Conditions: Hyperlipidemia|Hypercholesterolemia|Cardiovascular Disease|Diabetes|Chronic Kidney Disease (CKD)|Hypertension|Smoking|Myocardial Infarction (MI)|Unstable Angina|Angina|Coronary Artery Disease (CAD)|Stroke|Transient Ischemic Attack (TIA)|Carotid Stenosis|Peripheral Arterial Disease|Atherosclerosis|Claudication
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Uncemented Tritanium TKR vs Cemented Triathlon TKR
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Tritanium uncemented Total Knee Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Therapy in IschEmic Non-treatable Cardiac Disease
Status: COMPLETED
Conditions: Heart Failure
Interventions: BIOLOGICAL: CSCC_ASC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, of APG-2575 as a Single Agent or in Combination for Breast Cancer
Status: SUSPENDED
Conditions: Breast Cancer|Solid Tumor, Adult
Interventions: DRUG: APG-2575|DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mirtazapine Treatment of Anxiety in Children and Adolescents With Pervasive Developmental Disorders
Status: COMPLETED
Conditions: Autism Spectrum Disorders
Interventions: DRUG: Placebo|DRUG: Mirtazapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neo-adjuvant Transarterial Chemoinfusion (TAI) for Patients With Hepatocellular Carcinoma Beyond Milan/UCSF Criteria Who Underwent Liver Transplantation
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Liver Transplantation
Interventions: OTHER: Transarterial chemoinfusion (TAI) with mFOLFOX6 (oxaliplatin, calcium folinate, and 5-FU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VES001 in Healthy Participants
Status: COMPLETED
Conditions: Dementia, Frontotemporal
Interventions: DRUG: VES001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Psilocybin on MDD Symptom Severity and Synaptic Density
Status: COMPLETED
Conditions: Major Depressive Disorder|Depression
Interventions: DRUG: Psilocybin|DRUG: Niacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Manual Therapy and PNF Compared With Kinesiotherapy in the Treatment of Non-specific Low Back Pain
Status: COMPLETED
Conditions: Back Pain
Interventions: PROCEDURE: Manual therapy|PROCEDURE: PNF|PROCEDURE: Manual therapy + PNF|PROCEDURE: Kinesiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between the Lingually Based and the Buccally Based Triangular Flap Design in the Surgical Removal of Impacted Mandibular Third Molars
Status: COMPLETED
Conditions: Tooth, Impacted
Interventions: PROCEDURE: Lingually based triangular flap|PROCEDURE: Buccally based triangular flap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Implants Immediately Installed in Esthetic Area With Computer-guided Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Implants
Interventions: DEVICE: Guided surgery with bovine spongious bone substitute|DEVICE: Conventional surgery with bovine spongious bone substitute
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: King Vision Video Laryngoscope aBlade vs. Direct Laryngoscopy in Children
Status: UNKNOWN
Conditions: Tracheal Intubation
Interventions: DEVICE: Ambu King Vision Video Laryngoscope aBlade|DEVICE: Direct Laryngoscopy via Miller Straight Blade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Testing Different Amounts of the Combination of Drugs M1774 and ZEN-3694 for the Treatment of Recurrent Ovarian and Endometrial Cancer
Status: RECRUITING
Conditions: Endometrial Carcinoma|Endometrial Clear Cell Adenocarcinoma|Endometrial Endometrioid Adenocarcinoma|Endometrial Low Grade Endometrioid Adenocarcinoma|Ovarian Clear Cell Adenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian High Grade Serous Adenocarcinoma|Ovarian Low Grade Endometrioid Adenocarcinoma|Platinum-Resistant Ovarian Carcinoma
Interventions: DRUG: BET Bromodomain Inhibitor ZEN-3694|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Electrocardiography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Tuvusertib|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of PegIntron (Peginterferon Alfa-2b) and Rebetol (Ribavirin) in Treatment-naïve Subjects With Chronic Hepatitis C in Clinical Practice in Greece (Study P05209)
Status: COMPLETED
Conditions: Hepatitis C, Chronic|Hepatitis C
Interventions: BIOLOGICAL: PegIntron (peginterferon alfa-2b, pegylated interferon alfa-2b)|DRUG: Rebetol (ribavirin)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Do Musculoskeletal Techniques Improve Forced Expiratory Volume in One Second in Adults With Cystic Fibrosis?
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: OTHER: A treatment series of gentle joint and muscle movements|OTHER: Control group measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FOG-001 in Locally Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Cancer|Colorectal Cancer|Solid Tumor|Locally Advanced Solid Tumor|Metastatic Cancer|Gastric Cancer|Non-small Cell Lung Cancer|Non-small Cell Carcinoma|Non-small Cell Lung Cancer Metastatic|Non-small Cell Lung Cancer Stage IIIB|Non-Small Cell Carcinoma of Lung, TNM Stage 4|Gastroesophageal-junction Cancer|WNT Pathway|β-catenin|Beta-catenin|Adenomatous Polyposis Coli|APC
Interventions: DRUG: FOG-001|DRUG: FOG-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Intravitreal Triamcinolone and Retrobulbar Chlorpromazine as Alternatives to the Management of Painful Blind Eye
Status: COMPLETED
Conditions: Blind Painful Eye|Refractory Glaucoma|Control of Pain Through Drug Injection
Interventions: DRUG: Triamcinolone|DRUG: Chlorpromazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study in Advanced/Metastatic Solid Tumors With the Study Medicine (PF-07329640) When Given Alone or In Combination
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced or Metastatic Solid Tumors|Non-Small Cell Lung Cancer|Colorectal Cancer|Urothelial Cancer|Melanoma
Interventions: BIOLOGICAL: PF-07329640|BIOLOGICAL: sasanlimab|BIOLOGICAL: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interscalene Block and Dysfunction Diaphragmatic
Status: COMPLETED
Conditions: Diaphragmatic Paralysis
Interventions: DRUG: Ropivacaine 0.5% Injectable Solution|DRUG: Ropivacaine 0.1% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Adjuvant Concurrent Chemoradiation (CCRT) to Adjuvant Radiation Therapy (RT) in Grade 2 and 3 Extremity Soft Tissue Sarcomas
Status: COMPLETED
Conditions: Sarcoma,Soft Tissue
Interventions: RADIATION: adjuvant concurrent chemoradiation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neurobehavioural and Cognitive Changes in Cancer Cachexia (CANCOG)
Status: RECRUITING
Conditions: Cancer|Cachexia|Cachexia-Anorexia Syndrome|Appetite Loss|Weight Loss
Interventions: PROCEDURE: MRI/ Functional MRI|BEHAVIORAL: Self-reported questionnaires|BEHAVIORAL: Computer based tasks
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of 2-week Ketosis on the Heart's Ketone Body Consumption, Utilization, and Energetic Efficiency in Patients With Chronic Heart Failure
Status: RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: DIETARY_SUPPLEMENT: 3-hydroxybutyrat|DIETARY_SUPPLEMENT: Isocaloric placebo drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prepubertal Children With Growth Failure Associated With Primary Insulin-Like Growth Factor-1 (IGF-1) Deficiency
Status: COMPLETED
Conditions: Growth Disorders|Insulin-Like Growth Factor-1 Deficiency
Interventions: DRUG: rhIGF-1 (mecasermin, Tercica, Inc.)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermediate and Long Acting Insulin Young Children Type 1 Diabetes.
Status: UNKNOWN
Conditions: Type 1 Diabetes Mellitus With Hypoglycemia|type1diabetes
Interventions: DRUG: Degludec|DRUG: Glargine|DRUG: NPH insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comprehensive Treatment for Different Types of Tumor Thrombi in the Portal Vein for Hepatocellular Carcinoma Patients
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Portal Vein Tumor Thrombus
Interventions: DRUG: chemotherapy with endostar|DRUG: treatment with CBP and 5-FU|DRUG: treatment with endostar, CBP and 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Different Surgical Treatments for Different Scales of Cubital Tunnel Syndrome
Status: UNKNOWN
Conditions: Cubital Tunnel Syndrome
Interventions: PROCEDURE: simple decompression|PROCEDURE: anterior subcutaneous transposition|PROCEDURE: anterior intramuscular transposition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Moderate Sedation Combined With Acupuncture Anesthesia in Gastroscopy and Colonoscopy on Screening Research
Status: COMPLETED
Conditions: Gastrointestinal Endoscopy
Interventions: DRUG: fentanyl|PROCEDURE: eletroacupuncture(transcutaneous electrical acupuncture point stimulation )|DRUG: placebo needle|DRUG: remimazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extended Care in High-Risk Surgical Patient (EXCARE) Pathway in High-risk Surgical Population
Status: UNKNOWN
Conditions: Postoperative Complications|Patient Care Team
Interventions: BEHAVIORAL: Postoperative Monitoring|DIAGNOSTIC_TEST: High-sensitivity cardiac troponin testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Compare the Oral Bioavailability of Single Doses of Three Vapendavir Drug Formulations in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: vapendavir 132 mg capsule|DRUG: vapendavir 264 mg tablet|DRUG: vapendavir 24 mg/mL oral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: The Combination of Zanubrutinib and High-dose Dexamethasone as First-line Treatment in Adult Immune Thrombocytopenia
Status: NOT_YET_RECRUITING
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Zanubrutinib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Window of Opportunity Study for Investigating Drug Tolerant Persister (DTP) to Preoperative Brigatinib in Resectable Non-small Cell Lung Cancer (NSCLC) Harboring ALK Fusions.
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Brigatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Comparing the Self-test for Cervicovaginal Sample Versus Samples From Service Provider (Xyto-Ro)
Status: UNKNOWN
Conditions: Human Papillomavirus (HPV)-Related Cervical Cancer|HPV DNA
Interventions: DIAGNOSTIC_TEST: Cervical samples for identification of HR-HPV DNA via real-time PCTR.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Respiratory Muscle Training in Mechanically Ventilated Adults
Status: COMPLETED
Conditions: Respiratory Muscle Weakness
Interventions: OTHER: Respiratory muscle training|OTHER: Cardiopulmonary Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of NaproxenSodium and CodeinePhosphate Combination in Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Naproxen Sodium Codeine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The PROMPT Pilot Study
Status: COMPLETED
Conditions: Tobacco Use Disorder|Tobacco Dependence|Tobacco Use Cessation
Interventions: BEHAVIORAL: Smoking Cessation Counselling|DRUG: Nicotine Replacement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Cinematic Simulation on Emotions, Resilience, and Empathy Among Undergraduate Nursing Students
Status: COMPLETED
Conditions: Power of Cinematic Simulation on Emotions, Resilience, and Empathy Among Undergraduate Nursing Students
Interventions: BEHAVIORAL: Cinematic Simulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of White Button Mushroom on Inflammation in Obese Postmenopausal Women at High Risk of Breast Cancer
Status: RECRUITING
Conditions: Breast Carcinoma
Interventions: OTHER: Questionnaire Administration|DRUG: White Button Mushroom Extract
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: EFFECT OF LOW-LEVEL LASER THERAPY ON STABILITY OF DENTAL IMPLANTS PLACED IN A FRESH EXTRACTED SOCKET
Status: COMPLETED
Conditions: Dental Implant Stability
Interventions: OTHER: Collaplug with low level laser|OTHER: Collaplug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Clinical and Pharmacodynamic Study of MLN8237, A Novel Aurora A Kinase Inhibitor, in Participants With Advanced Malignancies
Status: COMPLETED
Conditions: Advanced Malignancies
Interventions: DRUG: alisertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conversion of Seddon III Nerve Injury to Seddon I/II Nerve Injury
Status: UNKNOWN
Conditions: Injury of Other Nerves at Wrist and Hand Level of Unspecified Arm, Initial Encounter
Interventions: DRUG: Polyethylene Glycols
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT