pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pharmacokinetics (PK) and Pharmacodynamics (PD) of Mayne Glucagon for Injection Compared With Glucagen® (Novo Nordisk) in Healthy Volunteers
Status: COMPLETED
Conditions: Hypoglycemia
Interventions: DRUG: Glucagen|DRUG: Mayne Glucagon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Corneal High Order Aberrations After Stream Light and Mechanical Photorefractive Keratectomy
Status: RECRUITING
Conditions: Compare Corneal High Order Aberrations Before and After Stream Light Trans-PRK and Mechanical Photorefractive Keratectomy
Interventions: OTHER: Photorefractive keratectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Trial That Will Study the Efficacy and Safety of an Investigational Drug in Acutely Psychotic People With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: SEP-363856 75mg|DRUG: SEP-363856 100mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Identification and Management of Comorbidities and Extra-intestinal Manifestations in Crohn's Disease: the NEMO Nurse-led Program
Status: RECRUITING
Conditions: Crohn Disease
Interventions: OTHER: NEMO nurse-led program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dosing Obese With Noxafil® Under a Trial (DONUT)
Status: COMPLETED
Conditions: Morbid Obesity
Interventions: DRUG: Posaconazole Injection [Noxafil] 300mg|DRUG: Posaconazole Injection [Noxafil] 400mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase II Study to Evaluate Safety and Immunogenicity of a Chikungunya Vaccine
Status: COMPLETED
Conditions: Chikungunya Virus Infection
Interventions: BIOLOGICAL: MV-CHIK low dose|BIOLOGICAL: MV-CHIK high dose|BIOLOGICAL: Priorix®|BIOLOGICAL: physiological saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Mifepristone and Misoprostol Versus Misoprostol Alone for Mid-trimester Termination of Pregnancy (14 - 21 Weeks LMP): A Randomized-controlled Double-blinded Trial
Status: COMPLETED
Conditions: Abortion, Induced
Interventions: DRUG: mifepristone+misoprostol|DRUG: misoprostol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effect of Specially Designed Insoles for Flat-footed Patients
Status: COMPLETED
Conditions: Flat Foot [Pes Planus] (Acquired), Unspecified Foot
Interventions: OTHER: ICB Medical Insoles|OTHER: ICM Insoles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Effectiveness of a Nasal Spray to Treat Perennial Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: azelastine/fluticasone 137/50 mcg nasal spray|DRUG: Dymista™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Alverine in the Treatment of Portal Hypertension in Patients With Liver Cirrhosis
Status: NOT_YET_RECRUITING
Conditions: Hypertension, Portal
Interventions: DRUG: Alverine|DRUG: Carvedilol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Cost-Effectiveness of Coronary CT Angiography Versus Myocardial SPECT in Patients With Intermediate Risk of Coronary Heart Disease
Status: UNKNOWN
Conditions: Chest Pain|Coronary Heart Disease Risk
Interventions: PROCEDURE: Myocardial SPECT|PROCEDURE: 64-channel coronary CT angiography (CCTA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clozapine CHAMPION-ECHO Educational Study to Improve Clozapine Use.
Status: ACTIVE_NOT_RECRUITING
Conditions: Schizophrenia Schizoaffective
Interventions: OTHER: Education Sessions|OTHER: No Education Session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Portrayals of Successful Treatment and Role Fulfillment on Mental Illness Stigma
Status: RECRUITING
Conditions: Mental Illness
Interventions: OTHER: Major Depressive Disorder without treatment or role fulfillment|OTHER: Major Depressive Disorder with treatment but no role fulfillment|OTHER: Major Depressive Disorder without treatment but with role fulfillment|OTHER: Major Depressive Disorder with treatment and role fulfillment|OTHER: Schizophrenia without treatment or role fulfillment|OTHER: Schizophrenia with treatment but no role fulfillment|OTHER: Schizophrenia without treatment but with role fulfillment|OTHER: Schizophrenia with treatment and role fulfillment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Phase II of Nivolumab Plus Ipilimumab in Non-resectable Sarcoma and Endometrial Carcinoma
Status: UNKNOWN
Conditions: Soft Tissue Sarcoma|Bone Sarcoma|Chondrosarcoma|Gastrointestinal Stromal Sarcoma|Ewing's Tumor Metastatic|Ewing's Tumor Recurrent|Osteosarcoma|Desmoplastic Small Round Cell Tumor
Interventions: DRUG: Ipilimumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed-Dose Combination ± Ribavirin in Treatment-Experienced Subjects With Genotype 1 HCV Infection
Status: COMPLETED
Conditions: Chronic Hepatitis C Virus
Interventions: DRUG: LDV/SOF|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intratumoral PH-762 for Cutaneous Carcinoma
Status: RECRUITING
Conditions: Squamous Cell Carcinoma of the Skin|Malignant Melanoma of Skin|Merkel Cell Carcinoma of Skin
Interventions: DRUG: PH-762
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DD-study: Diet or Diuretics for Salt-sensitivity in Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Amiloride|DRUG: Hydrochlorothiazide|OTHER: Low-sodium diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effectiveness of Three Types of Therapy for the Treatment of Anorexia Nervosa in Adolescents
Status: COMPLETED
Conditions: Eating Disorders
Interventions: BEHAVIORAL: Family therapy (FT)|BEHAVIORAL: Individual therapy (IT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase II Randomized Study of Glucocorticoids With or Without Methotrexate for Treatment of Giant Cell Arteritis
Status: COMPLETED
Conditions: Giant Cell Arteritis
Interventions: DRUG: methotrexate|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Rotator Cuff Sparing Total Arthroplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis|Inflammatory Arthritis
Interventions: PROCEDURE: TSR - traditional subscapularis release|PROCEDURE: TSR - rotator cuff sparing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Cervical Cap in the Diagnosis of Rupture of Membranes in the Second Trimester
Status: WITHDRAWN
Conditions: Fetal Membranes, Premature Rupture|Ultrasonography
Interventions: DEVICE: insemination cervical cap
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Routine Preoperative Antibiotic Prophylaxis in Modified Radical Mastectomy
Status: COMPLETED
Conditions: Surgical Infection
Interventions: PROCEDURE: Cefazolin|PROCEDURE: Sterile water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Tranexamic Acid in Preventing Postpartum Hemorrhage in High Risk Pregnancies During Elective Cesarean Section
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Tranexamic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Wii-Fit For Improving Activity, Gait And Balance In Alzheimer's Dementia
Status: COMPLETED
Conditions: Alzheimer's Dementia|Falls|Gait Impairment|Balance Impairment
Interventions: OTHER: Wii-Fit intervention|OTHER: Walking exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Testing the Superiority of CHF 1535 pMDI 800/24µg Total Daily Dose Compared to CHF 718 pMDI 800µg Total Daily Dose in Adults With Asthma on Medium or High-Dose Inhaled Corticosteroid
Status: ACTIVE_NOT_RECRUITING
Conditions: Asthma
Interventions: DRUG: Beclomethasone Dipropionate/Formoterol Fumarate|DRUG: Beclomethasone Dipropionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes Maxilla: Buffered 1% Lidocaine vs. Non-buffered 2% Lidocaine
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Nutraceuticals to Improve Lipid Profile in European Countries
Status: UNKNOWN
Conditions: Hyperlipidemia
Interventions: BEHAVIORAL: Non-pharmacologic intervention|DRUG: Nutraceuticals (Armolipid Plus)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Capecitabine and 131I-huA33 in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: DRUG: Capecitabine|DRUG: 131I-huA33 (131-Iodine on humanised monoclonal antibody A33)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Blend of Lavender-neroli Oils Aromatherapy and Music for Managing Anxiety in a Pediatric Patient
Status: COMPLETED
Conditions: Dental Anxiety
Interventions: BEHAVIORAL: Aromatherapy|BEHAVIORAL: Music|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Intraperitoneal Bevacizumab for Palliation of Intractable Malignant Ascites
Status: TERMINATED
Conditions: Malignant Ascites
Interventions: DRUG: Intraperitoneal Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: Protecting From Pneumococcus in Early Life (The PROPEL Trial)
Status: UNKNOWN
Conditions: Pneumonia
Interventions: BIOLOGICAL: 13-valent pneumococcal conjugate vaccine [Prevenar13®] plus tetanus toxoid|BIOLOGICAL: placebo 0.9% sodium chloride plus tetanus toxoid|OTHER: tetanus toxoid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose-ranging Study of a Single Administration of T-cell Add-back Depleted of Host Alloreactive Cells in Patients Undergoing a Peripheral Blood Stem Cell Transplant From a Related, Haploidentical Donor
Status: COMPLETED
Conditions: Hematologic Diseases|Hematologic Malignancies
Interventions: BIOLOGICAL: Donor lymphocyte preparation depleted of functional host alloreactive T-cells (ATIR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Isometric Exercises With and Without Pressure Biofeedback in Computer Users With Cervical Spine Overload
Status: COMPLETED
Conditions: Pain, Neck
Interventions: OTHER: pressure biofeedback|OTHER: isometric exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Whole-Body Vibration Training Versus Balance Training in Patients With Severe Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Balance Training on a vibration platform|OTHER: Conventional Balance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Protocol for a Virtual Reality Exposure Therapy for Fear of Flying.
Status: NOT_YET_RECRUITING
Conditions: Aerophobia|Virtual Reality Exposure Therapy|Randomized Controlled Trial|Anxiety
Interventions: BEHAVIORAL: Virtual reality-based exposure treatment with multimodal feedback (VRET-M)|BEHAVIORAL: Virtual reality-based exposure treatment with bimodal feedback (VRET-B)|BEHAVIORAL: Imagery exposure treatment (IET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of RQC for AMD
Status: UNKNOWN
Conditions: Age-related Macular Degeneration
Interventions: DRUG: Resveratrol, Quercetin, Curcumin (RQC)|DRUG: Curcumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Dexlansoprazole-based Triple and Rabeprazole-based Triple Therapies for Helicobacter Pylori Infection
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: dexlansoprazole based triple therapy|DRUG: rabeprazole-based triple therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pyrotinib and Subcutaneous Preparation of Trastuzumab Combined With Capecitabine Neoadjuvant Therapy for HER2+ Study of Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Pyrotinib and Subcutaneous preparation of trastuzumab combined with capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Monoclonal Antibody (J591) in Combination With Low-Dose Subcutaneous Interleukin-2
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: Monoclonal Antibody J591|DRUG: Recombinant Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Interventional Study to Compare the Efficacy and Tolerability With Targin® in Non-malignant Chronic Pain (GLORY)
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DRUG: Oxycodone/naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Conventional Low Flow Oxygenation Versus High Flow Nasal Cannula in Hypercapnic Respiratory Failure
Status: UNKNOWN
Conditions: Hypercapnic Respiratory Failure|Acute Copd Exacerbation
Interventions: DEVICE: High flow nasal cannula|DEVICE: Conventional low flow oxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pyrimethamine as a Treatment for Late-Onset GM2-gangliosidosis (Tay-Sachs and Sandhoff Disease)
Status: COMPLETED
Conditions: Gangliosidoses, GM2|Sandhoff Disease|Tay-Sachs Disease
Interventions: DRUG: Pyrimethamine|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial for Malaria Vaccine Candidate, PfPEBS (P. Falciparum Pre-Erythrocytic and Blood Stage)
Status: UNKNOWN
Conditions: Malaria
Interventions: BIOLOGICAL: Lyophilised PEBS synthetic protein (PfPEBS)|BIOLOGICAL: Lyophilised PEBS synthetic protein (PfPEBS)|OTHER: Rehydragel™ HPA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase I Study of a DNA Vaccine Encoding Androgen Receptor Ligand-Binding Domain (AR LBD) +/-GMCSF
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: pTVG-AR|BIOLOGICAL: gm-csf
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Dexmedetomidine on Tourniquet Pain Associated With Lower Extremity Surgeries Under General Anesthesia
Status: WITHDRAWN
Conditions: Orthopedic/Podiatry Procedures
Interventions: DRUG: Dexmedetomidine Hcl infusion|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): DNA Microarray Gene Expression Analysis
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: Rituximab|DRUG: Fludarabine phosphate|OTHER: Leukemic or stroma cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of AMP Human Sodium Bicarbonate Lotion on Hydration
Status: COMPLETED
Conditions: Fluid Retention|Fluid Loss|Sodium Retention|Cognitive Change|Heat Exposure|Hyperhydration|Electrolyte and Fluid Balance Conditions
Interventions: OTHER: PR Lotion - AMP Human Performance|OTHER: Placebo Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess Safety and Ability to Induce Immune Responses of HIV-1 Vaccines M3 and M4 Given Alone or in Combination in HIV-infected Adults
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: BIOLOGICAL: MVA.tHIVconsv3|BIOLOGICAL: MVA.tHIVconsv4|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Dry Needling and Deep Friction Massage in Patients With Subacromial Pain Syndrome
Status: COMPLETED
Conditions: Subacromial Impingement Syndrome|Trigger Point Pain, Myofascial
Interventions: DEVICE: Trigger Point Dry Needling Technique|OTHER: Deep Friction Massage Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of SPD489 in Preschool Children Aged 4-5 Years, Diagnosed With Attention-deficit/Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: DRUG: SPD489
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compact Closed System Versus Mounted Open System (COSMOS)
Status: COMPLETED
Conditions: Catheterization, Peripheral
Interventions: DEVICE: Open Intravenous System - Vasocan®|DEVICE: Closed Intravenous System - Nexiva®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Probiotic Chewables in Allergic Rhinoconjunctivitis Patients
Status: COMPLETED
Conditions: Allergic Rhinoconjunctivitis
Interventions: BIOLOGICAL: Probiotic chewables|BIOLOGICAL: Placebo chewables
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fibulink Syndesmosis Repair System With Early Full-Weight Bearing
Status: RECRUITING
Conditions: Ankle Fractures|Bimalleolar Fractures|Syndesmotic Injuries|Bimalleolar Equivalent Fracture|Maisonneuve Fracture|Trimalleolar Fractures|Ankle Dislocation
Interventions: OTHER: Early Weight Bearing|OTHER: Normal Weight Bearing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Discomfort Assessment of Senographe Pristina Patient-assisted Versus Standard Compression Mode and Quality Assessment of Screening Mammograms
Status: UNKNOWN
Conditions: Mammography Related Discomfort
Interventions: DEVICE: bilateral two-view (CC and MLO) FFDM (full field digital mammography) using patient-assisted compression mode|DEVICE: bilateral two-view (CC and MLO) FFDM (full field digital mammography) using standard compression mode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Effect of Food on Blood Levels of ASTX727
Status: COMPLETED
Conditions: Myelodysplastic Syndromes|Chronic Myelomonocytic Leukemia|Acute Myeloid Leukemia
Interventions: DRUG: ASTX727 + Day 2 Food|DRUG: ASTX727 + Day 4 Food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Mobile Application on Urinary Incontinence
Status: ENROLLING_BY_INVITATION
Conditions: Urinary Incontinence,Stress|Urinary Incontinence, Urge|Urinary Incontinence, Mixed|Symptoms|Kegel Exercises|Health, Subjective|Quality of Life
Interventions: OTHER: Training booklet prepared by the researchers on healthy lifestyle behaviors, bladder training, and Kegel exercises related to urinary incontinence.|OTHER: 3 months follow-up|BEHAVIORAL: Mobile application which named as "My Fighting with Incontinence"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Anesthetics and Auditory, Visceral, and Heat Evoked Potentials
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Propofol|DRUG: Remifentanil|DRUG: S-Ketamine|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sunitinib and Erlotinib in Treating Patients With Unresectable or Metastatic Kidney Cancer
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: DRUG: erlotinib hydrochloride|DRUG: sunitinib malate|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Isatuximab Combined With Bortezomib + Cyclophosphamide + Dexamethasone (VCD) and Bortezomib + Lenalidomide + Dexamethasone (VRD) in Newly Diagnosed Multiple Myeloma (MM) Non Eligible for Transplant or No Intent for Immediate Transplantation
Status: COMPLETED
Conditions: Plasma Cell Myeloma
Interventions: DRUG: lenalidomide|DRUG: bortezomib|DRUG: cyclophosphamide|DRUG: dexamethasone|DRUG: isatuximab SAR650984
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IFCT-GFPC 05.02 A Randomized Phase III Trial Assessing in Patients With Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Stage IV Non-small Cell Lung Cancer
Interventions: DRUG: observation|DRUG: gemcitabine|DRUG: erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Versus Delayed Induction in Term-PROM Using or Not Antibiotic Prophylaxis
Status: UNKNOWN
Conditions: Maternal Infection During Pregnancy (Diagnosis)|Neonatal Infection
Interventions: DRUG: Cefoxitin|DRUG: oxytocin/misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Olaparib and Alpelisib for Treatment of Metastatic Breast Cancer, A ComboMATCH Treatment Trial
Status: WITHDRAWN
Conditions: Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Metastatic HER2-Negative Breast Carcinoma|Unresectable HER2-Negative Breast Carcinoma
Interventions: DRUG: Alpelisib|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Olaparib|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Metastasis Inhibitor NP-G2-044 in Patients With Advanced or Metastatic Treatment-Refractory Solid Tumor Malignancies
Status: COMPLETED
Conditions: Breast Cancer|Pancreas Cancer|Prostate Cancer|Lung Cancer|Colon Cancer|Esophagus Cancer|Liver Cancer|Ovary Cancer|Advanced or Metastatic Treatment-refractory Solid Tumor Malignancies
Interventions: DRUG: NP-G2-044
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Ketoconazole on the Pharmacokinetics of JNJ-38518168 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-38518168 3 mg|DRUG: JNJ-38518168 30 mg|DRUG: JNJ-38518168 10 mg|DRUG: Ketoconazole 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Activity of 2 Dose Levels of Imetelstat in Participants With Intermediate-2 or High-Risk Myelofibrosis (MF) Previously Treated With Janus Kinase (JAK) Inhibitor
Status: COMPLETED
Conditions: Myelofibrosis
Interventions: DRUG: Imetelstat 4.7 mg/kg|DRUG: Imetelstat 9.4 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Smoking Environment on Craving and Smoking
Status: COMPLETED
Conditions: Smoking
Interventions: BEHAVIORAL: 6 hour smoking abstinence|BEHAVIORAL: Delay to Smoking Task (smoking cues)|BEHAVIORAL: Delay to Smoking Task (nonsmoking cues)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of Dehydroepiandrosterone (DHEA) in Women With Normal and Poor Ovarian Reserve Undergoing IVF
Status: COMPLETED
Conditions: Female Infertility Due to Diminished Ovarian Reserve
Interventions: DIETARY_SUPPLEMENT: Dihydroepiandrosterone (DHEA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Factors Predicting Response to Shunting in Normal Pressure Hydrocephalus
Status: TERMINATED
Conditions: Normal Pressure Hydrocephalus
Interventions: DEVICE: Programmable Shunt Insertion (Codman, Medtronic)|BEHAVIORAL: Assessments in physical therapy, occupational therapy, and speech therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Trial Investigating the Effect of 4 Weeks Dosing of XEN-D0501 on Blood Glucose Reduction in Patients With Diabetes
Status: COMPLETED
Conditions: Efficacy|Safety|Pharmacokinetics|Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo|DRUG: XEN-D0501
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study To Assess Safety, Tolerability and Efficacy of Intravenous Cabaletta in Patients With Machado-Joseph Disease
Status: COMPLETED
Conditions: Machado-Joseph Disease / Spinocerebellar Ataxia 3
Interventions: DRUG: Cabaletta for IV infusion once weekly during 24 weeks|DRUG: Cabaletta for IV infusion once weekly during 24 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Detecting Systemic Carbon Dioxide Levels With a Novel Biosensor
Status: NOT_YET_RECRUITING
Conditions: Hypercapnic Respiratory Failure|Pulmonary Disease, Chronic Obstructive|Neuromuscular Diseases|Obesity Hypoventilation Syndrome (OHS)
Interventions: DEVICE: IscAlert sensor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Therapy of Ventilator-associated Tracheobronchitis Caused by Gram Negative Bacteria With Nebulized Colistin
Status: UNKNOWN
Conditions: Bronchitis
Interventions: DRUG: Inhaled colistin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualized rTMS Based on fNIRS to Spasticity
Status: UNKNOWN
Conditions: Stroke|Spasticity, Muscle|Rehabilitation
Interventions: PROCEDURE: individual rTMS based on fNIRS|PROCEDURE: Traditional rTMS strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ALTERRA Post-Approval Study
Status: RECRUITING
Conditions: Pulmonary Valve Insufficiency|Complex Congenital Heart Defect|Tetralogy of Fallot|Pulmonary Regurgitation|RVOT Anomaly
Interventions: DEVICE: Edwards Alterra Adaptive Prestent with SAPIEN 3 Transcatheter Pulmonary Valve System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety and Tolerability of Arbaclofen Placarbil (XP19986) in Subjects With Acute Back Spasms
Status: COMPLETED
Conditions: Back Pain
Interventions: DRUG: Arbaclofen placarbil, 20 mg|DRUG: Placebo|DRUG: Arbaclofen placarbil, 30 mg|DRUG: Arbaclofen placarbil, 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Tranexamic Acid in Reduction of Post-Op Complications in Mohs Micrographic Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Skin Neoplasms
Interventions: DRUG: Tranexamic acid injection|DRUG: Lidocaine Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: RSV-MVA-BN Vaccine Phase II Trial in ≥ 55 Year Old Adults
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: MVA-BN-RSV|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effect of Vitamin D on Hospitalized Adults With COVID-19 Infection
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Cholecalciferol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A 12-Week Study in Asthmatic Children Ages 6 to <12 Years, Investigating the Efficacy and Safety of Symbicort pMDI 80/2.25 μg and Symbicort pMDI 80/4.5 μg, Compared With Budesonide pMDI 80 μg
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Symbicort pMDI|DRUG: Symbicort pMDI|OTHER: Budesonide pMDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of BPN14770 in Male Adults (Aged 18 to 45) With Fragile X Syndrome
Status: RECRUITING
Conditions: Fragile X Syndrome
Interventions: DRUG: BPN14770/ zatolmilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Trial Of Image Guided External Beam Radiotherapy With Or Without High Dose Rate Brachytherapy Boost In Men With Intermediate-Risk Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: RADIATION: Image guided external beam radiotherapy with or without brachytherapy boost|RADIATION: Brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Clinical Study to Evaluate the Use of Episodic, Intensive Blood Glucose Monitoring in Persons With Non-insulin Treated Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: Accu-Chek 360° View Blood Glucose Analysis Tool|DEVICE: Accu-Chek Aviva Glucose Meter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Safety and Efficacy of Eye Secret UV Aspheric Silicone Soft (Hydrophilic) 1Day Color Contact Lens
Status: ACTIVE_NOT_RECRUITING
Conditions: Myopia
Interventions: DEVICE: soft contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurostimulation for Cognitive Rehabilitation in Autistic Spectrum Disorders
Status: UNKNOWN
Conditions: Autistic Disorders Spectrum
Interventions: DEVICE: Transcranial Direct Current Stimulation (TDCS)- Active|DEVICE: Transcranial Direct Current Stimulation (TDCS)- Sham|BEHAVIORAL: Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Dosing Study of Glucagon-like Peptide 2 (GLP-2) in Infants and Children With Intestinal Failure
Status: TERMINATED
Conditions: Intestinal Failure|Short Bowel Syndrome
Interventions: DRUG: Glucagon-Like Peptide 2|DRUG: Glucagon like peptide-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carbon Dioxide Laser vs. Electrocoagulation for the Therapy of Condyloma
Status: RECRUITING
Conditions: Condylomata Acuminata
Interventions: DEVICE: Carbon dioxide Laser ablation|DEVICE: Electrocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pilonidal Sinus Disease
Status: RECRUITING
Conditions: Pilonidal Sinus
Interventions: PROCEDURE: laser ablation technique in the treatment of pilonidal sinus|PROCEDURE: Karydakis technique in the treatment of pilonidal sinus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Finding Study of Pramipexole (Sifrol) in Patients With Idiopathic Restless Legs Syndrome (RLS)
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: Pramipexole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Cytoreductive Prostatectomy Versus Cytoreductive Prostate Irradiation as a Local Treatment Option for Metastatic Prostate Cancer: a Multicentric Feasibility Trial
Status: RECRUITING
Conditions: Prostate Cancer Metastatic
Interventions: PROCEDURE: radical prostatectomy|RADIATION: Whole pelvis radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conducting Perioperative Code Status and Goals of Care Discussions: A Bi-Institutional Study to Develop a Novel, Evidence-Based Curriculum for Anesthesiology Trainees
Status: COMPLETED
Conditions: Shared Decision Making|End of Life
Interventions: BEHAVIORAL: Online Educational Modules (Videos)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Docetaxel, Radiation Therapy, and Hormone Therapy in Treating Patients With Locally Advanced Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Bicalutamide|DRUG: docetaxel|DRUG: GnRh analog|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of 18F-FAZA in Assessing Early Functional Response in Patients With Inoperable Non Small Cell Lung Cancer Undergoing Radiotherapy or Chemo-radiotherapy
Status: UNKNOWN
Conditions: Lung Neoplasm|Cell Hypoxia
Interventions: OTHER: 18F-FAZA|OTHER: 18F-Fluorodeoxyglucose (18F-FDG)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Everolimus TDM to Predict Long Term Toxicity
Status: UNKNOWN
Conditions: Breast Cancer|Renal Cell Carcinoma|Pancreatic Neuroendocrine Tumour|Gastrointestinal Neuroendocrine Tumour|Neuroendocrine Neoplasm of Lung
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized Controlled Trial of an Advanced Care Planning Video Decision Support Tool for Patients With End-Stage Liver Disease
Status: COMPLETED
Conditions: End Stage Liver Disease
Interventions: BEHAVIORAL: Advance Care Planning Video Decision Support Tool|OTHER: Verbal Narrative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of the Paclitaxel Eluting Covered Biliary Stent to the Common Covered Metallic Biliary Stent
Status: TERMINATED
Conditions: Biliary Stricture|Malignant Neoplasms
Interventions: DEVICE: biliary stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TD-1473 for Active Ulcerative Colitis (UC)
Status: COMPLETED
Conditions: Ulcerative Colitis, Active Moderate|Ulcerative Colitis, Active Severe
Interventions: DRUG: TD-1473|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma
Status: RECRUITING
Conditions: Primary Mediastinal Large B-Cell Lymphoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Computed Tomography|DRUG: Cyclophosphamide|DRUG: Doxorubicin Hydrochloride|PROCEDURE: Echocardiography|DRUG: Etoposide Phosphate|BIOLOGICAL: Filgrastim|PROCEDURE: Lumbar Puncture|BIOLOGICAL: Nivolumab|BIOLOGICAL: Pegfilgrastim|PROCEDURE: Positron Emission Tomography|DRUG: Prednisolone|DRUG: Prednisone|RADIATION: Radiation Therapy|BIOLOGICAL: Rituximab|BIOLOGICAL: Rituximab and Hyaluronidase Human|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IOP Patterns in Ocular Hypertensive Patients Newly Converted to Glaucoma vs Stable Ocular Hypertensive Patients
Status: TERMINATED
Conditions: Ocular Hypertension
Interventions: DEVICE: Sensimed Triggersfish® (TF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Longitudinal, Observational Study of Primary Ciliary Dyskinesia in Adults
Status: RECRUITING
Conditions: Primary Ciliary Dyskinesia
Interventions: DIAGNOSTIC_TEST: Spirometry|DIAGNOSTIC_TEST: Multiple Breath Washout (MBW)|DIAGNOSTIC_TEST: Mucociliary Clearance (MCC)|DIAGNOSTIC_TEST: CT of the chest|DIAGNOSTIC_TEST: MRI of the chest
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mindfulness, Empathy and the Oxytocinergic System in Persons With Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia Spectrum and Other Psychotic Disorders
Interventions: BEHAVIORAL: Mindfulness-based Group Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Achieving Lumbar Epidural Block Competency in Inexperienced Trainees After a Structured Teaching Model
Status: UNKNOWN
Conditions: Educational Problems
Interventions: DEVICE: Compuflo Epidural Training Instrument
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Combination Chemotherapy With or Without Thalidomide in Treating Patients With Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: recombinant interferon alfa|DRUG: cyclophosphamide|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: melphalan|DRUG: thalidomide|DRUG: vincristine sulfate|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Development of a Screening Questionnaire to Discriminate Autism Spectrum Disorder and Schizotypal Disorder, and Validation of the Danish Version of RAADS-R
Status: UNKNOWN
Conditions: Autism Spectrum Disorder|Schizotypal Disorder
Interventions: DIAGNOSTIC_TEST: Application of ZAQ and RAADS-R-DK
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Scapular Stabilization Excercise With Pectoralis Minor Stretching in Ballers Having Scapular Dyskinesia
Status: RECRUITING
Conditions: Scapular Dyskinesis|Pectoralis Minor Syndrome
Interventions: OTHER: stabilization exercises|OTHER: stabilization exercises along with pectoralis minor stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Curcumin to Improve Inflammation and Symptoms in Patients With Clonal Cytopenia of Undetermined Significance, Low Risk Myelodysplastic Syndrome, and Myeloproliferative Neoplasms
Status: RECRUITING
Conditions: Clonal Cytopenia of Undetermined Significance|Essential Thrombocythemia|Myelodysplastic Syndrome|Myelofibrosis|Polycythemia Vera
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|DIETARY_SUPPLEMENT: Curcumin/ Demethoxycurcumin/Bisdemethoxycurcumin-containing Supplement|DIETARY_SUPPLEMENT: Piperine Extract (Standardized)|DRUG: Placebo Administration|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Therapeutic Equivalence of Generic Permethrin Cream 5% to Elimite® in the Treatment of Scabies
Status: COMPLETED
Conditions: Scabies
Interventions: DRUG: Permethrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prognostic Analysis of Concurrent Chemoradiotherapy With/Without Adjuvant Chemotherapy for Locally Advanced NPC Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Local Advanced High Risk Nasopharyngeal Carcinoma
Interventions: DRUG: IMRT combine with cisplatin concurrent chemotherapy|DRUG: IMRT combine with cisplatin concurrent chemotherapy plus capecitabine adjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Study of SHP648, an Adeno-Associated Viral Vector for Gene Transfer in Hemophilia B Subjects
Status: TERMINATED
Conditions: Hemophilia B
Interventions: GENETIC: SHP648
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Radiotherapy With Capecitabine and Bevacizumab in Locally Advanced Rectal Cancer: CRAB Phase II Study
Status: UNKNOWN
Conditions: Locally Advanced Rectal Cancer
Interventions: DRUG: bevacizumab, capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery
Status: COMPLETED
Conditions: Cholecystitis|Endometriosis|Bowel Obstruction|Fibroids|Prostate Cancer|Chronic Kidney Disease|Uterine Prolapse
Interventions: PROCEDURE: Deep to Moderate NMB|PROCEDURE: Moderate to Deep NMB|DRUG: Rocuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Non-Pharmacological Treatments and Cognitive Impairment (NPT-CI2019)
Status: UNKNOWN
Conditions: Cognitive Impairment
Interventions: OTHER: CoRe software training plus non-invasive brain stimulation techniques (anodical tDCS / rTMS)|OTHER: CoRe software training plus sham non-invasive brain stimulation (sham tDCS/ sham rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease, Early Onset
Interventions: DRUG: BMS-986446|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT