pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of the Effects of an Oral Nitric Oxide Supplement on Blood Pressure in Prehypertensive Adults
Status: UNKNOWN
Conditions: Prehypertension
Interventions: DIETARY_SUPPLEMENT: Nitric Oxide supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fluorophotometry Evaluation of Lubricant Eye Drops
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Systane Free lubricant eye drops|OTHER: Visine Tears Lubricant Eye Drops|OTHER: Refresh Liquigel Lubricant Eye Drops|OTHER: Refresh Plus Lubricant Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Clinico-biological Collection of Autoimmune, Dysimmune or Auto-inflammatory Dermatological Diseases
Status: RECRUITING
Conditions: Autoimmune Bullous Dermatosis|Dysimmune Dermatological Diseases|Auto-inflammatory Dermatological Diseases|Skin Diseases
Interventions: BIOLOGICAL: Blood sampling|BIOLOGICAL: Remainders of samples taken as part of the treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Atomoxetine Versus Placebo in Children and Adolescents With ADHD and Comorbid ODD in Germany
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder|Oppositional Defiant Disorder
Interventions: DRUG: Atomoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Anti-CD4 mAb-Fragment for Imaging of Local Inflammation in Patients With Carotid Artery Stenosis
Status: UNKNOWN
Conditions: Carotid Stenosis
Interventions: RADIATION: EP 1645/Solution For Injection, 99mTC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prebiotic Effects of California Grapes on Gut Health and Cardiometabolic Health in Overweight Men and Women
Status: NOT_YET_RECRUITING
Conditions: Arterial Stiffness|Blood Pressure|Dysbiosis|Inflammation|Permeability; Increased
Interventions: DIETARY_SUPPLEMENT: Freeze-dried grape powder|OTHER: Placebo powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Pain Neuroscience Education on Clinical and Psychosocial Variables in Chronic Low Back Pain
Status: NOT_YET_RECRUITING
Conditions: Chronic Low-back Pain
Interventions: OTHER: Pain neuroscience Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Emotional Needs of Caregivers of Stem Cell Transplantation Patients
Status: COMPLETED
Conditions: Breast Cancer|Chronic Myeloproliferative Disorders|Gestational Trophoblastic Tumor|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases|Neuroblastoma|Ovarian Cancer|Psychosocial Effects of Cancer and Its Treatment|Testicular Germ Cell Tumor
Interventions: PROCEDURE: psychosocial assessment and care
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Evaluating the Synergism of Soluble Dietary Fiber With Fecal Microbiota Transplantation in Slow Transit Constipation
Status: UNKNOWN
Conditions: Slow Transit Constipation
Interventions: DRUG: Pectin|OTHER: Placebo|PROCEDURE: Fecal microbiota transplantation (FMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study Assessing the Safety and Efficacy of Pegcetacoplan in Post-Transplant Recurrence of C3G or IC-MPGN
Status: ACTIVE_NOT_RECRUITING
Conditions: C3G|IC-MPGN|Renal Transplant|Complement 3 Glomerulopathy|Complement 3 Glomerulopathy (C3G)|Dense Deposit Disease (DDD)|Membranoproliferative Glomerulonephritis|Membranoproliferative Glomerulonephritis (MPGN)|Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)|C3 Glomerulopathy|C3 Glomerulonephritis|Complement 3 Glomerulonephritis
Interventions: DRUG: Pegcetacoplan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3561774 in Participants With Mixed Dyslipidemia
Status: COMPLETED
Conditions: Dyslipidemias|Lipid Metabolism Disorders|Metabolic Diseases|Hyperlipoproteinemia
Interventions: DRUG: LY3561774|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: VERIFY:A Study to Compare Combination Regimen With Vildagliptin & Metformin Versus Metformin in Treatment-naïve Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Placebo of vildagliptin|DRUG: vildagliptin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retraining and Control Therapy (ReACT)- Adults
Status: NOT_YET_RECRUITING
Conditions: Convulsion, Non-Epileptic
Interventions: BEHAVIORAL: ReACT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Camrelizumab Combined With Intraperitoneal Infusion of Nab-paclitaxel, Intravenous Chemotherapy and S-1 in the Treatment of Advanced Gastric Cancer With Peritoneal Metastasis：Single-arm, Prospective Clinical Study
Status: UNKNOWN
Conditions: Stage IV Gastric Cancer With Metastasis
Interventions: DRUG: Camrelizumab; Nab-paclitaxel; S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diclofenac add-on to Treatment as Usual for Suicidal Patients
Status: WITHDRAWN
Conditions: Depression Suicidal
Interventions: DRUG: sugar pill|DRUG: Diclofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tecartherapy in the Treatment of Localized Fat and Sagging Abdominal Skin - Clinical and Experimental Study
Status: COMPLETED
Conditions: Fat Disorder|Fat Redistribution
Interventions: DEVICE: Tecartherapy Intervention|DEVICE: placebo tecartherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for the Treatment of Post-Traumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic
Interventions: PROCEDURE: Acupuncture|BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Self-monitoring Physical Activity With a SMARTphone Application in Cancer Patients: a Feasibility Study (SMART)
Status: COMPLETED
Conditions: Neoplasms
Interventions: DEVICE: RunKeeper App|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma
Status: UNKNOWN
Conditions: Childhood Malignant Fibrous Histiocytoma of Bone|Sarcoma
Interventions: DRUG: doxorubicin hydrochloride|DRUG: ifosfamide|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Benzalkonium Chloride Containing Eye Drops on the Conjunctival Bacterial Flora of Dry Eye Patients
Status: UNKNOWN
Conditions: Dry Eye Syndromes
Interventions: DRUG: Prosicca|DRUG: Prosicca sine|OTHER: Bacterial culture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Non Interventional Study to Investigate the Safety and Effectiveness in Patients With Relapsed and Refractory Multiple Myeloma Treated With Elranatamab Under the Actual Use.
Status: NOT_YET_RECRUITING
Conditions: Relapsed and Refractory Multiple Myeloma (RRMM)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Dupilumab in Patients With Persistent Asthma (Liberty Asthma Quest)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Dupilumab|DRUG: Placebo|DRUG: Inhaled corticosteroid (ICS) therapy|DRUG: Albuterol/Salbutamol|DRUG: Levalbuterol/Levosalbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, and Pharmacokinetics (PK) of Oseltamivir and Its Carboxylate Metabolite, RO0640802 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Oseltamivir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Sarcomas and DDR-Inhibition; a Combined Modality Study
Status: RECRUITING
Conditions: Soft Tissue Sarcoma Adult
Interventions: COMBINATION_PRODUCT: AZD1390 + radiotherapy|COMBINATION_PRODUCT: AZD1390 + durvlaumab + radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma
Status: RECRUITING
Conditions: Cholangiocarcinoma
Interventions: DRUG: Ivosidenib Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, One-arm and Open Clinical Study of Obinutuzumab in the Treatment of Immune Thrombocytopenia
Status: RECRUITING
Conditions: Immune Thrombocytopenia|Treatment
Interventions: DRUG: Obinutuzumab Injection [Gazyva]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Dose-dense EC Followed by ABX With PD-1 for Triple Negative Breast Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: epirubicin hydrochloride|DRUG: Cyclophosphamide|DRUG: Albumin bound paclitaxel|DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Modification Programme for Patients With Asymptomatic Carotid Artery Stenosis
Status: UNKNOWN
Conditions: Carotid Stenosis
Interventions: BEHAVIORAL: Risk Factors Modification Programme|BEHAVIORAL: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Double Filtration Plasmapheresis for Hepatitis C Virus (HCV) Genotype 1 Patients With High Viral Load
Status: TERMINATED
Conditions: Hepatitis C
Interventions: DRUG: DFPP + Peg-IFN + RBV|DRUG: Peg-IFN + RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Rozanolixizumab in Study Participants With Generalized Myasthenia Gravis
Status: COMPLETED
Conditions: Generalized Myasthenia Gravis
Interventions: DRUG: Rozanolixizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pracinostat and Gemtuzumab Ozogamicin (PraGO) in Patients With Relapsed/Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Relapsed Adult AML
Interventions: DRUG: Gemtuzumab Ozogamicin 3 mg/m^2|DRUG: Gemtuzumab Ozogamicin 2 mg/m^2|DRUG: Pracinostat - 45 mg|DRUG: Pracinostat - 60 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Adding Blood Flow Restriction to Strengthening Exercise in Patients With Patellofemoral Pain Syndrome
Status: NOT_YET_RECRUITING
Conditions: BFR|PFPS|Strengthening Exercises|Quadriceps Strength|Dynamic Balance|Joint Position Sense
Interventions: OTHER: BFR|OTHER: strengthening exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Concave Supra-arch Branched Stent-Graft System for Treatment of Aortic Arch Diseases
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Dissection|Aneurysm, Aortic Arch|Aortic Pseudoaneurysm|Aortic Ulcer, Penetrating|Aortic Intramural Hematoma
Interventions: DEVICE: Concave Supra-arch Branched stent-graft system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of PVI Plus Catheter Ablation or PVI Alone for the Treatment of AFib for Patients With Paroxysmal Atrial Fibrillation
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: PVI Plus Catheter Ablation|PROCEDURE: PVI Alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder
Status: COMPLETED
Conditions: Intermittent Explosive Disorder
Interventions: DRUG: Fluoxetine|DRUG: Divalproex|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of 68GA DOTATATE PET/CT In Breast Cancer Imaging
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DIAGNOSTIC_TEST: 18F FDG PET/CT|DIAGNOSTIC_TEST: 68Ga DOTATATE PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: PROnostic Interest of 18F-FDG PET/CT in Patients With Metastatic Castration-resistant Prostate Cancer (mCPRC) Progressing
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: DEVICE: PET scan of 18F-FDG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Remote Ischemic Preconditioning for Carotid Endarterectomy
Status: COMPLETED
Conditions: Carotid Stenosis|Endarterectomy, Carotid
Interventions: PROCEDURE: Remote Ischemic Preconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Observational Study of Gonal-F Filled by Mass Pens in Multifollicular Stimulation Prior to In-vitro Fertilization (IVF) or Intracytoplasmic Sperm Injection (ICSI)
Status: COMPLETED
Conditions: Multifollicular Stimulation
Interventions: DRUG: Gonal-F (Follitropin alfa)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Relationship Between the Menstrual Cycle and Heart Disease in Women
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DRUG: Ethinyl Estradiol-Levonorgestrel combination|DRUG: leuprolide acetate|DRUG: Estradiol|DRUG: Progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Safety and Effectiveness of Risperidone for the Treatment of Conduct Disorder and Other Disruptive Behavior Disorders in Children Ages 5 to 12 With Mild, Moderate, or Borderline Mental Retardation
Status: COMPLETED
Conditions: Conduct Disorder|Oppositional Defiant Disorder|Disruptive Behavior Disorder
Interventions: DRUG: Risperidone oral solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Transdermal System (DMTS) for Post-Operative Analgesia Following Bunionectomy
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: DMTS|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vinorelbine Plus Apatinib Versus Vinorelbine in Advanced Triple-Negative Breast Cancer
Status: COMPLETED
Conditions: Advanced Triple-Negative Breast Cancer
Interventions: DRUG: Vinorelbine|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regional Cerebral Oxygen Saturation in Laparoscopic Surgery
Status: UNKNOWN
Conditions: Cholecyctitis
Interventions: PROCEDURE: CO2 insufflation at intra-abdominal pressure 8 mmHg|PROCEDURE: CO2 insufflation at intra-abdominal pressure 12 mmHg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Young Male Patients With Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: prednisone|DRUG: vinblastine sulfate|DRUG: vincristine sulfate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melphalan Chemoreduction for Ocular Melanoma
Status: ENROLLING_BY_INVITATION
Conditions: Uveal Melanoma
Interventions: DRUG: Melphalan Injection|RADIATION: Plaque brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MicroRNAs and Prognosis in Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer Female|Metastases Breast
Interventions: DIAGNOSTIC_TEST: miRNA targeted analysis on breast cancer tissues|DIAGNOSTIC_TEST: miRNA targeted analysis on plasma samples|DIAGNOSTIC_TEST: miRNA profiling of breast cancer tissues
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Post-Injectable Cabotegravir Antiretroviral Salvage Strategy Options Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Prevention
Interventions: DRUG: TLD - Tenofovir Disoproxil Fumarate / Lamivudine / Dolutegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effectiveness of High Resolution Microendoscopy for People Living With HIV
Status: COMPLETED
Conditions: Anal High Grade Squamous Intraepithelial Lesion
Interventions: DIAGNOSTIC_TEST: mHRME (Mobile High resolution microendoscope)|DRUG: Proflavine Hemisulfate|DIAGNOSTIC_TEST: High resolution anoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effectiveness of the Multicomponent Therapy in Chronic Pain Through The Use of Smartphones
Status: COMPLETED
Conditions: Catastrophization|Chronic Pain|Pain, Chronic|Cognitive Therapy|Smartphones|Acceptance, Social
Interventions: OTHER: Multimodal pain therapy|OTHER: Standardized treatment.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Platelet Rich Fibrin With 1% Metformin Gel for Treatment of Intrabony Defects
Status: COMPLETED
Conditions: Periodontitis
Interventions: PROCEDURE: open flap debridement (OFD)|OTHER: Platelet rich fibrin (PRF)|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Robotic Rehabilitation Versus Traditional Balance Training on Balance and Fear of Falling in Stroke Patients
Status: UNKNOWN
Conditions: Stroke|Stroke Rehabilitation|Robotic Exoskeleton
Interventions: OTHER: Combined RAGT and TBT|OTHER: balance exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise Intervention Targeting Hip Strengthening Compared to Usual Care in Patients Undergoing Revision Hip Replacement
Status: RECRUITING
Conditions: Revision Total Hip Arthroplasty
Interventions: OTHER: Exercise Intervention Targeting Hip Strengthening|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clofarabine, Idarubicin, and Cytarabine Combination in Acute Myeloid Leukemia (AML) Induction
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Clofarabine|DRUG: Idarubicin|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient Reported Outcomes Targeting Early Chest Tube Removal (PROTECTR) Study
Status: NOT_YET_RECRUITING
Conditions: Lung Surgery|Chest Tube Removal|ERAS
Interventions: PROCEDURE: early chest tube removal
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PF-06372865 In Subjects With Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: DRUG: PF-06372865|DRUG: Placebo|DRUG: Naproxen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fecal Recovery of the Probiotic Bacteria Lactobacillus Rhamnosus GG (LGG) and Bifidobacterium Animalis Subspecies Lactis BB-12 (BB-12) in Healthy Humans Following Daily Consumption of a Probiotic Supplement
Status: COMPLETED
Conditions: Fecal Analysis
Interventions: DIETARY_SUPPLEMENT: ProNutrients Probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Oral Axl/Mer/CSF1R Selective Tyrosine Kinase Inhibitor in Patients With Advanced Solid Tumor
Status: RECRUITING
Conditions: Solid Tumor|Advanced Cancer|Metastatic Cancer
Interventions: DRUG: Q702
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Grade Serous Ovarian Carcinoma and Uterine Involvement : Should Hysterectomy be the Rule
Status: COMPLETED
Conditions: Serous Ovarian Carcinoma|Low Grade Serous Ovarian Carcinoma
Interventions: OTHER: Rate of myometrial involvement in the population of 28 low grade serous ovarian carcinoma.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Impact of Early Norepinephrine Administration on Outcomes of Patients With Sepsis-induced Hypotension
Status: COMPLETED
Conditions: Norepinephrine|Sepsis|Hypotension
Interventions: DRUG: Crystalloid|DRUG: noradrenaline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Arsenic Trioxide With Ascorbic Acid in the Treatment of Adult Non-Acute Promyelocytic Leukemia (APL) Acute Myelogenous Leukemia
Status: TERMINATED
Conditions: Acute Myelogenous Leukemia
Interventions: DRUG: Arsenic Trioxide (ATO)|DRUG: Ascorbic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BAY 43-9006 (Sorafenib) to Treat Relapsed Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small-Cell Lung Carcinoma
Interventions: DRUG: BAY 43-9006 (Sorafenib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 50% Body Weight Reverses Stature, Lumbar Disc Expansion and Vertebral Compliance by Hyper-Buoyancy Floatation.
Status: COMPLETED
Conditions: Intervertebral Disc Compression|Muscle Atrophy|Spine Injury
Interventions: DEVICE: Hyper-buoyancy Floatation (HBF)|DEVICE: Axial Load after 4h of HBF
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of a Digital Diabetes Self-Management Education and Support Program
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Online Diabetes Self-Management Education and Support (DSMES) Program|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ranibizumab Injections to Treat Macular Telangiectasia Without New Blood Vessel Growth
Status: COMPLETED
Conditions: Macular Telangiectasia
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Use of Combination of Anti-cholinergic and Minor Tranquilliser in the Treatment of Non-cardiac Chest Pain - a Double Blind Placebo Controlled Study
Status: UNKNOWN
Conditions: Chest Pain
Interventions: DRUG: chlordiazepoxide 5 mg, clidinium 2.5 mg, twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Skin Sparing Mastectomy and Immediate Breast Reconstruction With Latissimus Dorsi Flap After Neoadjuvant Chemotherapy and Radiotherapy (M-RIC)
Status: UNKNOWN
Conditions: Breast Carcinoma
Interventions: PROCEDURE: Mastectomy, preservation of the skin envelope,followed by immediate reconstruction with autologous latissimus dorsi flap.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Study for the Neoadjuvant Treatment of Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: Carboplatin|DRUG: Trastuzumab|DRUG: Pertuzumab|DRUG: Nab paclitaxel|DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: Docetaxel|DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: Nab paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Accuracy of Combined Localization Versus Single Localization in Non-palpable Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Breast-conserving Surgery
Interventions: PROCEDURE: Wire-guided localization and marker clip localization|PROCEDURE: Wire-guided localization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Investigate the Effect of Dapagliflozin on Ischemia Reperfusion Induced Endothelial Dysfunction
Status: UNKNOWN
Conditions: Reperfusion Injury|Vascular Complications
Interventions: DRUG: Dapagliflozin 10mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Analysis of Intestinal Microbiota as a Predictor of Response to Treatment of Spondyloarthritis With Biotherapy
Status: UNKNOWN
Conditions: Spondyloarthritis
Interventions: OTHER: stool sampling|OTHER: stool sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Breastfeeding Education and Support Provided to Male Partners on Optimal Breastfeeding Practice in Ethiopia
Status: COMPLETED
Conditions: Breastfeeding|Breast Fed|Breast Feeding, Exclusive|Breastfed|Breastfeeding, Exclusive
Interventions: BEHAVIORAL: Breastfeeding Education and Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Aerosol Inhalation Treatment for Dyspnea - Patients
Status: COMPLETED
Conditions: Dyspnea
Interventions: DRUG: Furosemide|DRUG: Aerosolized saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Corticosteroid Treatment for Community-Acquired Pneumonia - The STEP Trial
Status: COMPLETED
Conditions: Community-acquired Pneumonia
Interventions: DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Teriparatide on Maxillary Sinus Floor Osseointegration
Status: RECRUITING
Conditions: Bone Regeneration
Interventions: DRUG: Teriparatide|PROCEDURE: Maxillary Sinus Augmentation|PROCEDURE: Dental Implant Installation|COMBINATION_PRODUCT: Bone graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Allegra vs Sapien Transcatheter Aortic Valves in Valve-In-Valve Indication
Status: RECRUITING
Conditions: Aortic Valve Stenosis|Structural Valve Deterioration
Interventions: DEVICE: NVT ALLEGRA TAVI System TF|DEVICE: EDWARDS SAPIEN 3 or SAPIEN ULTRA SYSTEM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Metabolic Syndrome on Outcomes of Transforaminal Epidural Steroid Injection Treatment in Chronic Lumbar Radiculopathy
Status: UNKNOWN
Conditions: Herniated Disk Lumbar|Metabolic Syndrome
Interventions: PROCEDURE: transforaminal epidural steroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trichuris Suis Ova Treatment in Left-sided Ulcerative Colitis
Status: TERMINATED
Conditions: Colitis, Ulcerative
Interventions: BIOLOGICAL: Trichuris suis ova (TSO)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Changes in Bone Mineral Density as a Function of Consuming Two Different Forms of Calcium Carbonate
Status: UNKNOWN
Conditions: Osteopenia, Osteoporosis
Interventions: DIETARY_SUPPLEMENT: Micronized Calcium Carbonate|DIETARY_SUPPLEMENT: Non-Micronized Calcium Carbonate|DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Trial to Compare Intra-individually the Efficacy and Tolerance of Oleogel-S10 Versus Moist Wound Healing Dressing Alone in Accelerating the Epithelialization of Split Thickness Skin Graft Donor Sites
Status: COMPLETED
Conditions: Accelerating the Epithelialization of Split Thickness Skin Graft
Interventions: DRUG: Oleogel-S10|PROCEDURE: Moist wound healing dressings alone (Mepilex) on the other half of the skin graft donor site
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Early Versus Standard Drainage Removal After Pancreatic Resections
Status: COMPLETED
Conditions: Pancreaticoduodenectomy|Distal Pancreatectomy|Pancreatic Fistula|Abdominal Abscess
Interventions: PROCEDURE: Postoperative drain removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Combining Suicide Gene Therapy With Chemoradiotherapy in the Treatment of Non-Metastatic Pancreatic Adenocarcinoma
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: GENETIC: Ad5-yCD/mutTKSR39rep-ADP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Narrative or Fact-Based Videos in Increasing Colorectal Cancer Screenings in African American Communities
Status: COMPLETED
Conditions: Colorectal Cancer|Healthy, no Evidence of Disease
Interventions: BEHAVIORAL: behavioral intervention|BEHAVIORAL: behavioral intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Polyphenols and Cognitive Decline
Status: NOT_YET_RECRUITING
Conditions: Cognitive Decline|Cognitive Dysfunction
Interventions: DIETARY_SUPPLEMENT: Polyphenol Supplement|DIETARY_SUPPLEMENT: Placebo Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Role of Antibiotic Prophylaxis in Lowering Wound Infection Rates Post-Open Repair of Primary Elective Groin Hernias in High-Risk Patients
Status: RECRUITING
Conditions: Antibiotic Prophylaxis|Wound Infection|Groin Hernia
Interventions: DRUG: Cefazolin 1000 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: 4 Week Veterans Cannabidiol Intervention
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Vantage Hemp CBD|DIETARY_SUPPLEMENT: Vantage Hemp Placebo Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy and Safety Study of a New Cross-linked Hyaluronan Hydrogel in the Reduction of Postsurgical Peritoneal Adhesions
Status: COMPLETED
Conditions: Myomas|Ovary Cysts|Endometriotic Cysts|Adhesions
Interventions: OTHER: Saline|DEVICE: Cross-linked Hyaluronan Hydrogel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Differential Metabolism of Dietary Fatty Acids
Status: COMPLETED
Conditions: Obesity|Diabetes|Hyperlipidemia
Interventions: DIETARY_SUPPLEMENT: Oleic acid (OA)|DIETARY_SUPPLEMENT: Palmitic Acid (PA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vertical Expandable Prosthetic Titanium Rib (VEPTR) for Thoracic Insufficiency Syndrome
Status: COMPLETED
Conditions: Thoracic Insufficiency Syndrome (TIS)
Interventions: DEVICE: Synthes VEPTR (Vertical Expandable Prosthetic Titanium Rib)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: OCT Versus Angiography for Culprit Lesion Revascularization in Acute Myocardial Infarction PatiEnts
Status: RECRUITING
Conditions: ST Elevation Myocardial Infarction|Myocardial Infarction
Interventions: PROCEDURE: Angiography-guided PCI group|PROCEDURE: Optical coherence tomography-guided PCI group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Trans-Cutaneous Electrical Nerve Stimulation (TENS) Alleviate The Pain Experienced During Bone Marrow Sampling?
Status: COMPLETED
Conditions: Pain
Interventions: DEVICE: Trans-cutaneous Electrical Nerve Stimulation (TENS)|DRUG: Standard pain relief (ie. local anaesthetic with or without inhaled nitrous oxide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: MT2018-18: Sleeping Beauty Transposon-Engineered Plasmablasts for Hurler Syndrome Post Allo HSCT
Status: WITHDRAWN
Conditions: Mucopolysaccharidosis Type IH (MPS IH, Hurler Syndrome)|Mucopolysaccharidosis Type IH|MPS IH, Hurler Syndrome
Interventions: DRUG: Autologous Plasmablasts
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Labeled Pilot Study of Atorvastatin in Systemic Lupus Erythematosus
Status: UNKNOWN
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Performance Evaluation of the LumiraDx Point Of Care D-dimer Assay
Status: UNKNOWN
Conditions: Deep Vein Thrombosis|Pulmonary Embolism|Venous Thromboembolism
Interventions: DIAGNOSTIC_TEST: Venepuncture|DIAGNOSTIC_TEST: Fingerstick
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Investigate the Objective Response Rate of Dabrafenib in Combination With Trametinib in Subjects With BRAF V600 Mutation-Positive Melanoma
Status: COMPLETED
Conditions: Cancer|Melanoma
Interventions: DRUG: Dabrafenib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurocardiac Interactions Evaluated by Anatomic and Physiologic MRI Assessment
Status: WITHDRAWN
Conditions: Ischemia|Stress, Mental
Interventions: RADIATION: Coronary CT Angiography|OTHER: Mood Symptom Scale|OTHER: Anxiety Symptom Scale|OTHER: Chronic Stress Inventories|OTHER: Psychosocial Function Questionnaires|OTHER: General Health and quality of life questionnaires|OTHER: Magnetic Resonance Imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized, Double-blind, Placebo Controlled Phase III Study to Investigate Efficacy and Safety of First-Line Treatment With HLX10 + Chemotherapy (Carboplatin-Nanoparticle Albumin Bound (Nab) Paclitaxel) in Patients With Stage IIIB/IIIC or IV NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Squamous Non Small Cell Lung Cancer
Interventions: DRUG: HLX10|DRUG: carboplatin and nab paclitaxel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin B12 and Folinic Acid Supplementation in Mitochondrial DNA Deletion Syndromes
Status: NOT_YET_RECRUITING
Conditions: Mitochondrial DNA Deletion|Macrocytosis
Interventions: DIETARY_SUPPLEMENT: Folinic acid (oral); Cyanocobalamin sublingual
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Low Plasma Mannose Binding Lectin (p-MBL) Level is a Risk Factor for Recurrent Pregnancy Loss (RPL)
Status: COMPLETED
Conditions: Recurrent Miscarriage|Spontaneous Abortion|Mannose-Binding Lectin Deficiency|Habitual Abortion|Pregnancy Complications|Pregnancy Loss|Recurrent Pregnancy Loss
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure - UCSF
Status: RECRUITING
Conditions: Appendicitis
Interventions: DRUG: Multiple standard of care antibiotics for appendicitis, at physicians' discretion|DRUG: Multiple standard of care antibiotics for appendicitis, at physicians' discretion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Safety and Efficacy of Ranibizumab in Patients With Choroidal Neovascularisation Due to Causes Other Than Age Related Macular Degeneration
Status: COMPLETED
Conditions: Choroidal Neovascularization|Retinal Pigment Epithelial Detachment
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of GSP3 on Body Weight in Overweight and Obese Subjects
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: DEVICE: GSP3|DIETARY_SUPPLEMENT: Avicel (modified Cellulose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study to Evaluate QR-010 in Subjects With Cystic Fibrosis ΔF508 CFTR Mutation
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: QR-010
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Psychosocial ADHD Interventions - Brief Parent Training
Status: COMPLETED
Conditions: ADHD|ADHD - Combined Type|ADHD Predominantly Inattentive Type|ADHD, Predominantly Hyperactive-Impulsive Type|Behavior Problem|Behavioral Problem|Problem Behavior|Behavioral Symptoms|Child Behavior Problem|Disruptive Behavior
Interventions: BEHAVIORAL: Brief behavioral parent training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ascorbate With Durvalumab in Non-Small Cell Lung Cancer (NSCLC)
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Durvalumab|DRUG: Pharmacological ascorbate|PROCEDURE: Surgery (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Open-label, Rollover Study Providing Continued Dosing of Gevokizumab in Order to Assess Long-term Gevokizumab Safety Data
Status: TERMINATED
Conditions: Uveitis
Interventions: DRUG: Dose 2 gevokizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Propranolol in Patients With Post Traumatic Stress Disorder (PTSD)
Status: TERMINATED
Conditions: Post-traumatic Stress Disorder
Interventions: DRUG: Propranolol Hydrochloride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Virtual Reality and Brain Stimulation, an Experiential Approach
Status: COMPLETED
Conditions: Acrophobia
Interventions: DEVICE: VR + active brain stimulation|DEVICE: VR + sham brain stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells With or Without NKTR-255 in Adults With Recurrent or Refractory B Cell Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: B Acute Lymphoblastic Leukemia|CD19 Positive|Minimal Residual Disease|Philadelphia Chromosome Positive
Interventions: BIOLOGICAL: Chimeric Antigen Receptor T-Cell Therapy|DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration|DRUG: NKTR-255
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Virtual Reality Technologies and Telemedicine for Cognitive Rehabilitation in Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: PROCEDURE: Cognitive rehabilitation using interactive tablet|PROCEDURE: Cognitive rehabilitation using smartphone App Medico Amico
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's Type
Status: NOT_YET_RECRUITING
Conditions: Agitation
Interventions: DRUG: 12 cm2 - 2 Active DMTS Patches|DRUG: 6 cm2 - 1 Active and 1 Placebo DMTS Patches|DRUG: Placebo - 2 Placebo DMTS Patches
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EUS-guided CDS vs ERCP as First Line in Malignant Distal Obstruction in Borderline Disease (CARPEDIEM-2 Trial)
Status: NOT_YET_RECRUITING
Conditions: Malignant Biliary Obstruction|Pancreatic Cancer|Biliary Tract Neoplasms
Interventions: PROCEDURE: Endoscopic biliary drainage|DEVICE: Self-expandable metallic stent (SEMS)|DEVICE: Lumen-apposing metal stent (LAMS) and double-pigtail plastic stent (DPPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes After Standard and High-Flexion Posterior Stabilized Rotating-Platform Mobile-Bearing Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Standard PS RP-MB (P.F.C Sigma Rotating Platform knee)|DEVICE: High-flexion PS RP-MB (P.F.C Sigma Rotating Platform Flex)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Metoprolol in Acute Myocardial Infarction. A PK/PD Study
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Metoprolol- Toprol XL|DRUG: Metoprolol- Lopressor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of AMG 994 Monotherapy and AMG 994 and AMG 404 Combination Therapy in Participants With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: AMG 994|DRUG: AMG 404
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT