pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Regorafenib Combined With Fulvestrant in Recurrent Low-Grade Serous Ovarian Cancer
Status: RECRUITING
Conditions: Ovarian Cancer|Serous Ovarian Cancer
Interventions: DRUG: Regorafenib|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Haploidentical Stem Cell Transplantation and NK Cell Therapy in Patients With High-risk Solid Tumors
Status: UNKNOWN
Conditions: Neuroblastoma|Ewing Sarcoma|Rhabdomyosarcoma|Osteosarcoma|Soft Tissue Sarcoma
Interventions: PROCEDURE: haploidentical stem cell transplantation and NK cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BCMA Chimeric Antigen Receptor Expressing T Cells in Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: Anti-BCMA CAR-T cells|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation and Evaluation of the Selection Scheme of Peripheral Venous Infusion Devices for Hospitalized Children
Status: COMPLETED
Conditions: Children,Hospitalized|Vascular Access Devices
Interventions: OTHER: the selection scheme of peripheral venous access devices|OTHER: the existing nursing routine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tolerance of Regular Meal Intake With Mycoprotein (TOMMY)
Status: COMPLETED
Conditions: Gastrointestinal Complication
Interventions: OTHER: Fermotein based meals|OTHER: Matching control meals with whey protein and wheat bran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Humidified High Flow Nasal Cannula as Compared to Nasal Continuous Positive Airway Pressure
Status: COMPLETED
Conditions: Respiratory Distress Syndrome|Cronic Lung Disease
Interventions: DEVICE: High Flow Nasal Cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Visual Function and Driving Health Using Ocusweep in Patients Suffering From Wet Age-related Macular Degeneration
Status: UNKNOWN
Conditions: Macular Degeneration
Interventions: DEVICE: Ocusweep system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Optimized Antiretroviral Therapy During Allogeneic Hematopoietic Stem Cell Transplantation in HIV-1 Individuals
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Enfuvirtide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Global Postural Reeducation (GPR) Program With Hamstring Stretch for Patients With Low Back Pain
Status: COMPLETED
Conditions: Back Pain
Interventions: OTHER: Global Postural Reeducation Program|OTHER: Hamstring Stretch Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GPPAD-POInT (Global Platform of Autoimmune Diabetes - Primary Oral Insulin Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Oral Insulin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intracoronary Analysis of Cardiac Allograft Vasculopathy by Means of Optical Coherence Tomography
Status: UNKNOWN
Conditions: Intimal Proliferation|Immunosuppression
Interventions: OTHER: Protocol with Everolimus (Certican®)|OTHER: Protocol with Mycophenolate mofetil (CellCept®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-Centre, Randomized, Double-Blind, Placebo Controlled Pilot Trial to Assess the Efficacy, Safety, and Tolerability of SPM 927 in Subjects With Postherpetic Neuralgia (PHN).
Status: COMPLETED
Conditions: Postherpetic Neuralgia
Interventions: DRUG: SPM927/Lacosamide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on "Pain Control of Cervical Dilation by Lidocaine Solution Injected Into a Disposable Cervical Dilator"
Status: ENROLLING_BY_INVITATION
Conditions: Cervical Dilatations
Interventions: PROCEDURE: Disposable cervical dilator stick combined with lidocaine hydrochloride injection|PROCEDURE: Disposable cervical dilator stick combined with normal saline injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of an Online Training and Support Program (iSupport) for Informal Dementia Caregivers
Status: SUSPENDED
Conditions: Caregiver Subjective Burden|Depressive Symptoms|Anxiety Symptoms
Interventions: BEHAVIORAL: iSupport for dementia - European-Portuguese version|OTHER: e-book (comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Anterolateral Watson Jones Approach Versus Transgluteal Approach for Uncemented Hemi- Arthroplasty in Displaced Femoral Neck Fracture
Status: COMPLETED
Conditions: Femoral Neck Fracture
Interventions: PROCEDURE: hemiarthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy of Ranibizumab in Different Regimens in Patients With Diabetic Macula Edema
Status: COMPLETED
Conditions: Diabetic Retinopathy
Interventions: DRUG: ranibizumab 0.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Obinutuzumab Versus Rituximab for Acute Lymphoblastic Leukemia/PALG ALL7 OVERALL
Status: NOT_YET_RECRUITING
Conditions: CD20-positive Acute Lymphoblastic Leukemia
Interventions: DRUG: Obinutuzumab|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Ablative Radiotherapy for Hepatocellular Carcinoma With Major Portal Vein Invasion
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Portal Vein Tumor Thrombus
Interventions: RADIATION: Stereotactic ablative radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OptiMATe: De-escalated Induction Treatment in Primary CNS Lymphoma
Status: RECRUITING
Conditions: Primary Central Nervous System Lymphoma
Interventions: DRUG: Experimental Treatment: one course Rituximab/HD-Methotrexate, two courses of MATRix|DRUG: Control intervention: four courses of MATRix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Family-Based Behavioral Treatments for Youth With Anxiety and Obsessive-Compulsive Disorder
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder in Children|Anxiety Disorder of Childhood|Social Anxiety Disorder of Childhood|Obsessive-Compulsive Disorder in Adolescence|Generalized Anxiety Disorder|Separation Anxiety|Panic Disorder|Panic Disorder With Agoraphobia|Panic Attacks
Interventions: BEHAVIORAL: Family Based, Internet-Based Cognitive Behavioral Therapy|BEHAVIORAL: Bibliotherapy, low therapist contact SPACE|OTHER: Relaxation and Mentorship
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of BG136 Injection in Healthy Chinese Volunteers
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: BG136|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Plaque Removal Efficacy of Powered and Manual Toothbrush Among Children With Cerebral Palsy
Status: RECRUITING
Conditions: Cerebral Palsy, Mixed
Interventions: DEVICE: Manual Toothbrush and Powered Toothbrush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Locally Advanced Unresectable Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: irinotecan hydrochloride|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Postoperative Patient-controlled Perineural Analgesia After Orthopedic Surgery by "Remote Control" Versus "Bedside Care"
Status: TERMINATED
Conditions: Injury of Foot, Shoulder or Knee|Perineural Analgesia|Pain, Postoperative
Interventions: OTHER: Remote control|OTHER: At bedside care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Enhanced Nutrition for Preterm Infants
Status: COMPLETED
Conditions: Preterm Birth
Interventions: OTHER: Enhanced Intravenous Nutrition|OTHER: Standard Intravenous Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Effectiveness of Intervertebral Disc Release in Treating Lenke 5 Adolescent Idiopathic Scoliosis
Status: RECRUITING
Conditions: Adolescent Idiopathic Scoliosis
Interventions: PROCEDURE: intervertebral disc release|PROCEDURE: Ponte osteotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maralixibat in Patients With Cystic Fibrosis and Constipation, A Within-Subjects Pilot Study
Status: NOT_YET_RECRUITING
Conditions: Constipation Chronic Idiopathic|Cystic Fibrosis
Interventions: DRUG: Maralixibat 9.5 MG/ML [Livmarli]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Children Recovering From Tonsil Surgery
Status: UNKNOWN
Conditions: Tonsillitis
Interventions: COMBINATION_PRODUCT: Acupuncture, acupressure|DIETARY_SUPPLEMENT: Timbal diet|OTHER: Extended telephone counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AZD6738 First Time in Patient Multiple Ascending Dose Study
Status: COMPLETED
Conditions: 11q-deleted Relapsed/Refractory Chronic Lymphocytic Leukaemia (CLL),|Prolymphocytic Leukaemia (PLL)|B Cell Lymphomas
Interventions: DRUG: Administration of AZD6738
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Confirmation Bias Towards Treatments of Depressive Disorders in Social Tagging
Status: COMPLETED
Conditions: Major Depressive Disorder, Recurrent|Depressive Episode|Depressive Disorder, Major|Depression
Interventions: OTHER: Social Tag Popularity|OTHER: Confidence in Prior Attitudes|OTHER: Source Credibility
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Spinal Cord Compression Re-Treat Study
Status: COMPLETED
Conditions: Pain|Radiation Toxicity|Spinal Cord Compression|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: RADIATION: Cumulative BED ≤ 100|RADIATION: Cumulative BED ≤ 130 Gy2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Open-label Trial of Belzupacap Sarotalocan (AU-011) in Bladder Cancer
Status: RECRUITING
Conditions: Non-muscle-invasive Bladder Cancer|Muscle-Invasive Bladder Carcinoma
Interventions: DRUG: AU-011|COMBINATION_PRODUCT: AU-011 in Combination with Medical Laser Adminstration|COMBINATION_PRODUCT: AU-011 in Combination with Medical Laser Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy & Safety of Orally Administered Valsartan/Amlodipine Combo Therapy vs Amlodipine Monotherapy in Patients With Stage II Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: valsartan + amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Freeze-dried Human Rabies Vaccine (Vero Cells)
Status: ACTIVE_NOT_RECRUITING
Conditions: Rabies Vaccine Adverse Reaction|Safety and Efficacy
Interventions: BIOLOGICAL: Freeze-dried human rabies vaccine (Vero cells) Zhifeilongkoma - 5-dose program|BIOLOGICAL: Freeze-dried human rabies vaccine (Vero cells) Zhifeilongkoma - 4-dose program|BIOLOGICAL: Freeze-dried human rabies vaccine (Vero cells) Chengda - 5-dose program|BIOLOGICAL: Freeze-dried human rabies vaccine (Vero cells) Chengda - 4-dose program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Buffered Lidocaine for Loop Electrosurgical Excision Procedures (LEEPs)
Status: COMPLETED
Conditions: Uterine Cervical Dysplasia
Interventions: DRUG: sodium bicarbonate buffered lidocaine|DRUG: Non-buffered lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fluoxetine for Motor, Aphasia, and Neglect Recovery After Ischemic Stroke
Status: WITHDRAWN
Conditions: Stroke
Interventions: DRUG: fluoxetine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stent-Retriever for Acute Massive Pulmonary Embolism (SRAME)
Status: NOT_YET_RECRUITING
Conditions: PE - Pulmonary Embolism|PE - Pulmonary Thromboembolism
Interventions: DEVICE: Stent-Retriever
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety, Tolerability, and Pharmacokinetics of Multiple Oral Doses of EDP-788
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: EDP-788|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stand up to Cancer: MAGENTA (Making Genetic Testing Accessible)
Status: RECRUITING
Conditions: BARD1 Gene Mutation|BRCA1 Gene Mutation|BRCA2 Gene Mutation|BRIP1 Gene Mutation|Estrogen Receptor Negative|HER2/Neu Negative|MLH1 Gene Mutation|MSH2 Gene Mutation|MSH6 Gene Mutation|PALB2 Gene Mutation|PMS2 Gene Mutation|Progesterone Receptor Negative|RAD51C Gene Mutation|RAD51D Gene Mutation|Triple-Negative Breast Carcinoma
Interventions: OTHER: Educational Intervention|OTHER: Genetic Counseling|OTHER: Genetic Counseling|OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Comparative Study to Assess the Prevention of Surgical Site Infection (SSI's) in Revision Total Joint Arthroplasty Patients Treated With Single-Use Negative Pressure Wound Therapy (PICO™) or Standard Care Dressings (AQUACEL® Ag SURGICAL Dressing)
Status: UNKNOWN
Conditions: Surgical Wound Infection
Interventions: DEVICE: Aquacel Ag Surgical Dressing|DEVICE: Single-Use Negative Pressure Wound Therapy (PICO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: PREVENTION
Clinical trial: Comparison of Electric Heating Pad Versus Forced-air Warming to Prevent Inadvertent Perioperative Hypothermia
Status: UNKNOWN
Conditions: Temperature Change, Body|Hypothermia; Anesthesia
Interventions: DEVICE: WARMTAC|DEVICE: 3M Bair Hugger
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Age-adjusted D-dimer Cut-off Levels to Rule Out Pulmonary Embolism
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: OTHER: Evaluation of a modified DD cut-off to rule out PE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate Safety and Efficacy of HS-10296 as First-Line Treatment in Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: HS-10296|DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Carboplatin and Pemetrexed Plus Demcizumab (OMP-21M18) in Subjects With Non-Squamous Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Demcizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD19 CAR-T Consolidation Therapy for Acute Lymphoblastic Leukemia
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia, Adult B-Cell
Interventions: BIOLOGICAL: CD19 CAR-T cells infusion combined with feeding T cells (FTCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prostate Cancer Survivors and Exercise and Behavioral Counseling
Status: COMPLETED
Conditions: Physical Activity|Cancer of the Prostate|Cognitive Impairment|Quality of Life
Interventions: BEHAVIORAL: Supervised Physical Activity Plus Behavioral Counseling|BEHAVIORAL: Supervised Physical Activity Plus Exercise Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Safety, Tolerability, and Pharmacokinetics Study of MK-8189 in Participants With Schizophrenia and in Healthy Participants (MK-8189-007)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: MK-8189|DRUG: Placebo|DRUG: Background AAP Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Occupational Therapy in Patients With Rheumatoid Arthritis(RCT)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BEHAVIORAL: psycho-educational Joint protection education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Accuracy of Electrocardiogram for Acute Coronary Occlusion Resulting in Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction|Acute Coronary Syndrome|Coronary Artery Disease
Interventions: RADIATION: Coronary angiogram
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety and Effectiveness of a Nasal Spray to Treat Seasonal Allergies
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Placebo|DRUG: azelastineHcl|DRUG: fluticasone propionate|DRUG: azelastine Hcl/fluticasone propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetic Drug Interaction Between Multiple Doses of JNJ-31001074 and a Single Dose of an Oral Contraceptive Containing Ethinyl Estradiol and Levonorgestrel in Women
Status: WITHDRAWN
Conditions: Pharmacokinetics|Drug Interactions|Healthy
Interventions: DRUG: JNJ-31001074
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Improving Arm and Hand Functions in Chronic Stroke (CIHR 2012-2015)
Status: COMPLETED
Conditions: Stroke|Upper Extremity Paresis
Interventions: BEHAVIORAL: Music Supported Rehabilitation|BEHAVIORAL: Conventional Upper Extremity Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy Combined With Antidepressants to Reduce HIV Risk and Drug Relapse Among Depressed Intravenous Drug Users
Status: COMPLETED
Conditions: HIV Infections|Depression|Substance-Related Disorders
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Psychopharmacology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intramuscular Progesterone Supplementation on Clinical and Ongoing Pregnancy Rates in Patients With Low Serum Progesterone Levels on the Day of Embryo Transfer in Artificial Frozen Cycles
Status: COMPLETED
Conditions: Serum Progesterone Levels|Progesterone Supplementation|Frozen Embryo Transfer|Clinical Pregnancy Rates|Ongoing Pregnancy Rates
Interventions: DRUG: Twice-daily transvaginal progesterone supplementation|DRUG: Twice-weekly intramuscular + Twice-daily transvaginal progesterone supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Innovative Approaches in Diabetes Care
Status: RECRUITING
Conditions: Diabetes Mellitus|Mobile Application|Dietary Assessment|M-health
Interventions: BEHAVIORAL: "3D/AR MetaFood " nutrition education, and receive instant feedback from the nutritionists or AI after recording their dietary food image.|BEHAVIORAL: conventional nutrition education by dietitian
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: International Multicentre Study in Advanced Anal Cancer Comparing Cisplatin Plus 5 FU vs Carboplatin Plus Weekly Paclitaxel
Status: UNKNOWN
Conditions: Squamous Cell Carcinoma of the Anus
Interventions: DRUG: Cisplatin|DRUG: 5-Fluorouracil (5-FU)|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study: Sintilimab and R-CHOP in PMBCL Treatment
Status: NOT_YET_RECRUITING
Conditions: Primary Mediastinal Large B Cell Lymphoma
Interventions: DRUG: Combined anti-PD-1 and R-CHOP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-dose RAD001(Everolimus) Plus Cisplatin-HDFL Chemotherapy for the First-line Treatment of Advanced Gastric Cancer
Status: COMPLETED
Conditions: Metastatic Gastric Cancer
Interventions: DRUG: RAD001; Cisplatin; 5-FU; Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Pectin Supplementation in Diarrhea-predominant Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Pectin|DIETARY_SUPPLEMENT: maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3154207 in Healthy Participants and Participants With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: LY3154207|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: People Living With HIV, Oral and Oropharyngeal Cancer, and Health Equity
Status: NOT_YET_RECRUITING
Conditions: HIV Infections|Oral Squamous Cell Carcinoma|Oropharyngeal Squamous Cell Carcinoma
Interventions: OTHER: Group Meeting (Focus Group)|OTHER: Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy Study of Intravenous Sodium Valproate in Addition to First Line Anti Epileptic Treatment of Generalized Convulsive Status Epilepticus.
Status: COMPLETED
Conditions: Generalized Convulsive Status Epilepticus|Intensive Care Unit
Interventions: DRUG: Intravenous Sodium Valproate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of HRS-6209 in Combination With Fulvestrant, Letrozole, HRS-8080, or HRS-1358 in Breast Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Advanced Unresectable or Metastatic Breast Cancer
Interventions: DRUG: HRS-6209 in Combination with Fulvestrant|DRUG: HRS-6209 in Combination with HRS-1358|DRUG: HRS-6209 in Combination with Letrozole|DRUG: HRS-6209 in Combination with HRS-8080|DRUG: HRS-6209 in Combination with HRS-1358
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of VAS203 (Ronopterin) in Patients With Moderate and Severe Traumatic Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: DRUG: VAS203|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Algorithm for Identifying Persistent Nasal Staphylococcus Aureus Carriage in a Cohort of Healthy Volunteers and Patients Regularly Monitored at the CHU of Saint-Etienne
Status: COMPLETED
Conditions: Staphylococcal Infections
Interventions: OTHER: Staphylococcus aureus carriage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Carboplatin/Paclitaxel +/-Gemcitabine in Treating Patients With Ovarian Epithelial or Fallopian Tube Cancer
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Ovarian Cancer
Interventions: DRUG: TCG|DRUG: TC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Phase 2, Neoadjuvant Study of Weekly Paclitaxel With or Without LCL161 in Patients With Triple Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: LCL161|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LMP-specific T-cells for Patients With Relapsed EBV-positive Lymphoma
Status: COMPLETED
Conditions: Hodgkin Disease|Non Hodgkin Lymphoma|Lymphoepithelioma|Leiomyosarcoma
Interventions: BIOLOGICAL: LMP1/2 CTLs (ALCI - Group A)|BIOLOGICAL: LMP1/2 CTLs (ALCI - Group B)|BIOLOGICAL: LMP1/2 CTLs (ALCI - Group C)|BIOLOGICAL: LMP2 CTLs (ALSCER - Group A)|BIOLOGICAL: LMP2 CTLs (ALSCER - Group B)|BIOLOGICAL: LMP2 CTLs (ALSCER - Group C)|BIOLOGICAL: LMP1/2 CTLs (ALCI - Expansion - Group A)|BIOLOGICAL: LMP1/2 CTLs (ALCI - Expansion Group B)|BIOLOGICAL: LMP1/2 CTLs (ALCI - Expansion Group C)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Effects of Darifenacin and Oxybutynin Extended Release in Volunteers Aged 60 and Over
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Darifenacin|DRUG: Oxybutynin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Safety and Efficacy of the Selumetinib Granule Formulation in Children Aged ≥1 to <7 Years With NF1-related Symptomatic, Inoperable PN
Status: ACTIVE_NOT_RECRUITING
Conditions: Neurofibromatosis Type 1
Interventions: DRUG: Selumetinib granule formulation|DRUG: Selumetinib capsule formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TOX NEG Trial: Clostridium Difficile Diagnosis and Treatment
Status: COMPLETED
Conditions: Clostridium Difficile Infection|Diarrhea
Interventions: DRUG: Oral Vancomycin|DRUG: Placebo|DEVICE: Toxin enzyme immunoassay|DEVICE: Nuceleic acid amplification test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Assess the Anti-Emetic Efficacy of Ginger in Children and Adolescents Receiving Chemotherapy
Status: UNKNOWN
Conditions: Nausea|Vomiting
Interventions: DIETARY_SUPPLEMENT: Provision of capsules containing ginger powder or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Eye Movement Desensitization and Reprocessing (EMDR) for Police Personnel
Status: RECRUITING
Conditions: Suicidal Ideation|Psychological Trauma|Stress
Interventions: BEHAVIORAL: Eye Movement Desensitization and Reprocessing (EMDR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IMS-treatment and Canalis Carpi Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: DEVICE: Needle in acupuncture point Li11|DEVICE: IMS of the musculus pronator teres
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Computer-Based Survey and Communication Aid in Improving Physician-Patient Communication and Treatment Decision Making in Patients With Metastatic Cancer
Status: COMPLETED
Conditions: Metastatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: OTHER: counseling intervention|OTHER: educational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Learning Study: Improving Vision in Adults With Macular Degeneration
Status: RECRUITING
Conditions: Macular Degeneration
Interventions: DEVICE: Active anodal tDCS|DEVICE: Sham anodal tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of SPH3127 In Patients With Mild-moderate Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: SPH3127 tablet|DRUG: SPH3127 tablet|DRUG: SPH3127 tablet|DRUG: Valsartan|DRUG: SPH3127 tablet|DRUG: Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-GDC-0941 Following Single Oral Dose Administration in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: GDC-0941
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vorinostat Plus Tacrolimus & Methotrexate to Prevent Graft vs Host Disease Following Unrelated Stem Cell Transplant
Status: COMPLETED
Conditions: Graft vs Host Disease|Hematologic Neoplasms|Non-Neoplastic Hematologic and Lymphocytic Disorder
Interventions: DRUG: Vorinostat|DRUG: Tacrolimus|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Eplivanserin Treatment for Sleep Maintenance Insomnia
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders|Insomnia
Interventions: DRUG: Eplivanserin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of CS1-targeted CAR-T Cells Therapy for Relapsed Multiple Myeloma After BCMA CAR-T Cells Therapy
Status: NOT_YET_RECRUITING
Conditions: Relapse Multiple Myeloma
Interventions: DRUG: CS1 Targeted CAR T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Processing Therapy (CPT) for Posttraumatic Stress Disorder and Borderline Personality Disorder (PTSD-BPD)
Status: RECRUITING
Conditions: Posttraumatic Stress Disorder|Borderline Personality Disorder
Interventions: BEHAVIORAL: Cognitive Processing Therapy with Suicide Risk Management|BEHAVIORAL: Treatment as Usual with Suicide Rick Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Dual-task Exercise Training to Prevent Falls Among Older Adults With Mild Cognitive Impairment
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Accidental Falls|Aging
Interventions: BEHAVIORAL: dual-task tai ji quan|BEHAVIORAL: standard tai ji quan|BEHAVIORAL: stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Evaluate the Safety, Tolerability and Pharmacokinetics of CT-P63 in Healthy Subjects
Status: COMPLETED
Conditions: SARS-CoV-2 Infection
Interventions: DRUG: CT-P63|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Three Doses of Florence Oral Suspension in Adults With Eosinophilic Esophagitis
Status: RECRUITING
Conditions: Eosinophilic Esophagitis
Interventions: DRUG: Florence 30 μg/mL|DRUG: Florence 60 μg/mL|DRUG: Florence 90 μg/mL|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Emergency Delirium in Pediatrics Undergoing Tonsillectomy and Adenoidectomy
Status: NOT_YET_RECRUITING
Conditions: Emergence Delirium
Interventions: DRUG: Dexmedetomidine and Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence of LB80380 Free Base and Maleate Salt Tablets
Status: COMPLETED
Conditions: Hepatitis B
Interventions: DRUG: LB80380 maleate salt|DRUG: LB80380 free base
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Prevention of Lateral Incisional Hernia After Stomal Closure Using P4HB Retro-muscular Mesh
Status: UNKNOWN
Conditions: Incisional LLQ Hernia
Interventions: PROCEDURE: Mesh augmentation|PROCEDURE: Direct suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Psychoeduc Interv. Through Meta-universes on Condom's Use Self - Efficacy and Sexual Behavior in Students of UAChile
Status: TERMINATED
Conditions: Sexually Transmitted Diseases|Sexually Transmitted Diseases, Viral|Sexually Transmitted Diseases, Bacterial
Interventions: BEHAVIORAL: Psychoeducational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Leuprolide Acetate or Goserelin Acetate Compared With Observation in Treating Patients With High-Risk Prostate Cancer Who Have Undergone Radical Prostatectomy
Status: TERMINATED
Conditions: Prostate Adenocarcinoma|Stage IIA Prostate Cancer|Stage IIB Prostate Cancer|Stage III Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: Goserelin Acetate|OTHER: Laboratory Biomarker Analysis|DRUG: Leuprolide Acetate|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sofosbuvir, Ribavirin, for the Treatment of Chronic Hepatitis C Virus Genotype 1 in HIV-Coinfected Patients Receiving Fixed Dose Co-formulation Emtricitabine/ Tenofovir/Cobicistat/Elvitegravir: A Pilot Study
Status: COMPLETED
Conditions: Hepatitis C Infection|HIV Infection
Interventions: DRUG: Sofosbuvir, Ribavirin, and Stribild
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Pembrolizumab + Decitabine Followed by Std Neoadj Chemo for Locally Advanced HER2- Breast Ca
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Adenocarcinoma|Estrogen Receptor- Negative Breast Cancer|Estrogen Receptor-positive Breast Cancer|HER2/Neu Negative|Invasive Breast Carcinoma|Progesterone Receptor Negative|Progesterone Receptor Positive Tumor|Stage II Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Triple-negative Breast Carcinoma
Interventions: DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Decitabine|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Varenicline (Chantix®) in the Treatment of Friedreich's Ataxia
Status: TERMINATED
Conditions: Friedreich's Ataxia
Interventions: DRUG: varenicline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeted Fortification of Donor Breast Milk in Preterm Infants
Status: RECRUITING
Conditions: Prematurity; Extreme|Failure to Thrive in Newborn|Growth Retardation|Growth Failure|Infant Nutrition Disorders
Interventions: DIETARY_SUPPLEMENT: Similac Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid|DIETARY_SUPPLEMENT: Similac Liquid Protein Fortifier|DIETARY_SUPPLEMENT: Nestle Microlipid|DIETARY_SUPPLEMENT: Medica Nutrition SolCarb|DIETARY_SUPPLEMENT: Similac Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid (Targeted Fortification)|DIETARY_SUPPLEMENT: Similac Liquid Protein Fortifier (Targeted Fortification)|DIETARY_SUPPLEMENT: Nestle Microlipid (Targeted Fortification)|DIETARY_SUPPLEMENT: Medica Nutrition SolCarb (Targeted Fortification)|OTHER: Analysis with Miris (AB) Human Milk Analyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Lactation Fortification Study
Status: COMPLETED
Conditions: Lactation
Interventions: DIETARY_SUPPLEMENT: Similac Prenatal Vitamin soft-gel capsule|DIETARY_SUPPLEMENT: Placebo (soybean oil and dl-alpha-tocopheryl acetate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Let It Out (LIO) and COVID19: Testing an Online Emotional Disclosure-based Intervention During the COVID19 Pandemic
Status: TERMINATED
Conditions: COVID19
Interventions: OTHER: Let It Out (LIO)-C|OTHER: Neutral writing control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer
Status: RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Early Stage Triple-Negative Breast Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Carboplatin|DRUG: Cyclophosphamide|DRUG: Docetaxel|DRUG: Doxorubicin|DRUG: Paclitaxel|BIOLOGICAL: Pembrolizumab|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Surgical Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wireless Brain-computer-interface-controlled Neurorehabilitation System for Patients With Stroke
Status: UNKNOWN
Conditions: Cerebrovascular Accident
Interventions: DEVICE: BCI-controlled neurorehabilitation device|BEHAVIORAL: Standard rehabilitation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis|Lou Gehrig's Disease|Primary Lateral Sclerosis|Nervous System Diseases|Hereditary Spastic Paraparesis
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: FIB Grifols Congenital Deficiency for On-demand Treatment and Surgical Prophylaxis
Status: WITHDRAWN
Conditions: Congenital Afibrinogenemia|Hypofibrinogenemia
Interventions: BIOLOGICAL: FIB Grifols
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Irinotecan Plus Cetuximab With or Without Enzastaurin in Participants With Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Colorectal Carcinoma|Colorectal Tumor
Interventions: DRUG: enzastaurin|DRUG: irinotecan|DRUG: cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of R744 to Hemodialysis Patients
Status: COMPLETED
Conditions: Hemodialysis Patients
Interventions: DRUG: R744|DRUG: R744|DRUG: rHuEPO|DRUG: rHuEPO|DRUG: R744 placebo|DRUG: rHuEPO placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Remote Ischemic Preconditioning on Cognitive Function After Off-Pump Coronary Artery Bypass Graft
Status: UNKNOWN
Conditions: Ischemic Heart Disease
Interventions: PROCEDURE: remote ischemic preconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Study of Loxoprofen Sodium Transdermal Patch and Loxonin® Tablets for the Treatment of Acute Trauma
Status: COMPLETED
Conditions: Trauma|Pain
Interventions: DRUG: Transdermal Patch|DRUG: Loxoprofen sodium|DRUG: Placebo (for loxoprofen sodium)|DRUG: Placebo (for transdermal patch)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: THC Crossover Study
Status: COMPLETED
Conditions: THC|Cannabis|Cannabis Smoking|Cannabis Use, Unspecified|Cigarette Smoking|Tobacco Use|Nicotine Dependence|Nicotine Withdrawal|Cardiovascular Risk Factor
Interventions: OTHER: Smoked Cannabis|OTHER: Vaped Cannabis|OTHER: Tobacco Cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Improving Vision in Adults With Macular Degeneration
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DEVICE: anodal tDCS Active Stimulation|DEVICE: anodal tDCS Sham/Placebo Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Visual Outcomes After Cataract Surgery: Multifocal AcrySof® IQ ReSTOR® Intraocular Lenses Versus Monofocal Intraocular Lenses
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: AcrySof® IQ ReSTOR® +3.0 D Multifocal IOL|DEVICE: AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric IOL|DEVICE: Monofocal IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Efficacy of Hydroxychloroquine and Azithromycin to Prevent Hospitalization or Death in Persons With COVID-19
Status: TERMINATED
Conditions: COVID-19|SARS-CoV 2
Interventions: DRUG: Hydroxychloroquine (HCQ)|DRUG: Azithromycin (Azithro)|DRUG: Placebo for Hydroxychloroquine|DRUG: Placebo for Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT