pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Analgesic Effect of Different Combinations of Dexketoprofen Trometamol With Tramadol Hydrochloride in a Model of Moderate to Severe Pain
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Dexketoprofen Trometamol|DRUG: Dexketoprofen Trometamol|DRUG: Tramadol Hydrochloride|DRUG: Tramadol Hydrochloride|DRUG: Ibuprofen|DRUG: Placebo|DRUG: Dexketoprofen Trometamol + Tramadol Hydrochloride|DRUG: Dexketoprofen Trometamol + Tramadol Hydrochloride|DRUG: Dexketoprofen Trometamol + Tramadol Hydrochloride|DRUG: Dexketoprofen Trometamol + Tramadol Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Acetazolamide on Visuo-motor Learning in Lowlanders Older Than 40 Years at Altitude
Status: COMPLETED
Conditions: Altitude Hypoxia
Interventions: DRUG: ACETAZOLAMIDE oral capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Study of Two Platinum Regimens in Triple Negative Breast Cancer
Status: COMPLETED
Conditions: Triple-negative Breast Cancer
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Ibrutinib in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma|Grade 1 Follicular Lymphoma|Grade 2 Follicular Lymphoma|Grade 3a Follicular Lymphoma|Mediastinal Lymphoma|Recurrent B-Cell Non-Hodgkin Lymphoma|Recurrent Burkitt Lymphoma|Recurrent Diffuse Large B-Cell Lymphoma|Recurrent Follicular Lymphoma|Recurrent Lymphoplasmacytic Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Waldenstrom Macroglobulinemia|Refractory B-Cell Non-Hodgkin Lymphoma|Refractory Burkitt Lymphoma|Refractory Diffuse Large B-Cell Lymphoma|Refractory Follicular Lymphoma|Refractory Lymphoplasmacytic Lymphoma|Refractory Mantle Cell Lymphoma
Interventions: DRUG: Ibrutinib|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-market Study of the DREAMS 2G Drug Eluting Absorbable Metal Scaffold (BIOSOLVE-III)
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Artery Stenosis
Interventions: DEVICE: Percutaneous Coronary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Compare the Safety and Pharmacokinetics of YH22162 in Healthy Volunteers
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan 80mg + Amlodipine 5mg + Chlorthalidone 25mg|DRUG: Telmisartan 80mg + Amlodipine 5mg + Chlorthalidone 25mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SUNOSI® (Solriamfetol) Pregnancy Registry
Status: RECRUITING
Conditions: Narcolepsy|Obstructive Sleep Apnea|Pregnant Women and Their Offspring
Interventions: DRUG: Sunosi (solriamfetol)|DRUG: Other prescription wake-promoting medications or stimulants|OTHER: No treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating Combination Immunotherapy for Advanced Cholangiocarcinoma With Pembrolizumab and PEG-Intron
Status: TERMINATED
Conditions: Advanced Cholangiocarcinoma
Interventions: DRUG: Pembrolizumab|DRUG: Sylatron
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Certolizumab Pegol on Semen Quality in Healthy Male Volunteers
Status: COMPLETED
Conditions: Sperm Quality
Interventions: BIOLOGICAL: Certolizumab pegol|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: The Effects of IMT on Physical Activity and Quality of Life in LTx Candidates
Status: COMPLETED
Conditions: Lung Transplantation|Inspiratory Muscle Training
Interventions: OTHER: Inspiratory muscle training|OTHER: Pulmonary rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Osteopathic Manipulative Treatment Effects on High Frequency Parameters in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subject|Heart Rate Variability
Interventions: OTHER: Osteopathic manipulative treatment|OTHER: SHAM|OTHER: CONTROL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Lipoprotein(a) in Patients With Cardiovascular Disease (CVD)
Status: COMPLETED
Conditions: Cardiovascular Disease and Lipoprotein(a)
Interventions: DIAGNOSTIC_TEST: Blood draw for Lp(a)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: IBER Salvage Treatment Followed by Ibrutinib Maintenance for Relapsed or Refractory PCNSL
Status: UNKNOWN
Conditions: Primary Central Nervous System Lymphoma
Interventions: DRUG: IBER salvage chemotherapy followed by ibrutinib maintenance therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Efficacy of a Novel Oral Supplement in Tackling Malnutrition in the Elderly
Status: UNKNOWN
Conditions: Malnutrition|Muscle Health
Interventions: DIETARY_SUPPLEMENT: ONS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate Lenalidomide Plus Dexamethasone in Patients With Newly Diagnosed POEMS Syndrome
Status: COMPLETED
Conditions: POEMS Syndrome
Interventions: DRUG: Lenalidomide, Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Nutritional Trial on Effect of L. Rhamnosus Yoba on RTI and Other Health Outcomes Among Children (3-6 Years) in Uganda
Status: UNKNOWN
Conditions: Skin Diseases|Respiratory Tract Infections|Diarrhea
Interventions: DIETARY_SUPPLEMENT: Lactobacillus rhamnosus yoba 2012
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Kappa-CD28 T Lymphocytes, Chronic Lymphocytic Leukemia, B-cell Lymphoma or Multiple Myeloma, CHARKALL
Status: RECRUITING
Conditions: Lymphoma|Myeloma|Leukemia
Interventions: BIOLOGICAL: Kappa CD28 T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arsenic Trioxide With or Without Tretinoin in Treating Patients With Hematologic Cancer That Has Not Responded to Previous Therapy
Status: TERMINATED
Conditions: Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
Interventions: DRUG: arsenic trioxide|DRUG: tretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Periimplant Mucosa Dynamics Around Divergent and Concave Atlantis Abutment Transition Profiles
Status: COMPLETED
Conditions: Dental Implant, Single-Tooth|Esthetics, Dental
Interventions: DEVICE: Concave Transition Profile|DEVICE: Divergent Transition Profile
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Second-Line Treatment Choice for Epilepsy
Status: UNKNOWN
Conditions: Adults With Tonic Clonic Seizures and/or Partial Seizures
Interventions: DRUG: Carbamazepine|DRUG: Lamotrigine|DRUG: Levetiracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mucocutaneous Manifestations in Patients With Chronic Kidney Disease inNewVally and Assuit;Hospital Based Study
Status: NOT_YET_RECRUITING
Conditions: Chronic Kidney Diseases|Manifestation, Skin
Interventions: OTHER: observe pattern of mucocutaneous manifestations in chronic kidney disease patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Comparing Two Analgesia/Sedation Regimens, Remifentanil/Propofol Versus Sufentanil/Propofol In Mechanically Ventilated Intensive Care Patients Requiring Analgesia And Sedation.
Status: TERMINATED
Conditions: Analgesia|Sedation
Interventions: DRUG: Sufentanil|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PaREnting ProgrAm to Enhance PREterm Infants' Health and Development (PREPARE Trial)
Status: RECRUITING
Conditions: Behavioral Assessment of Children|Early Intervention
Interventions: BEHAVIORAL: Comprehensive structured parent intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate Safety and Immunogenicity of Haemophilus Influenzae Serotype A Vaccine
Status: RECRUITING
Conditions: Haemophilus Influenzae Meningitis|Invasive Haemophilus Influenzae Disease
Interventions: BIOLOGICAL: Haemophilus influenzae type a (Hia) glycoconjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Consented Unsedated Endoscopy in High Risk Patients That Require Anesthesiologist Observation During the Procedure
Status: COMPLETED
Conditions: Patient Satisfaction
Interventions: PROCEDURE: un-sedated colonoscopies
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pazopanib In Stage IIIB/IV NSCLC Lung Cancer After Progression on First Line Therapy Containing Bevacizumab
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Noradrenaline on Coagulation and Fibrinolysis in Severe Isolated Brain Injury
Status: UNKNOWN
Conditions: Brain Injuries, Traumatic|Coagulopathy|Coagulation Defect; Acquired|Coagulation Defect; Bleeding|Fibrinolytic Hemorrhage, Acquired
Interventions: DRUG: noradrenaline
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Big Feelings: A Study on Children's Emotions in Therapy
Status: RECRUITING
Conditions: Anxiety Disorders|Depressive Disorder|Mood Disorders|Conduct Disorder|Oppositional Defiant Disorder|Regulation, Emotion|Child Behavior Disorders|Trauma and Stressor Related Disorders
Interventions: BEHAVIORAL: Modular Approach to Therapy for Children with Anxiety, Depression, Trauma or Conduct Problems
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endo- and Epicardial vs. Endocardial Ablation of Ventricular Tachycardia in Patients With Cardiac Disease
Status: UNKNOWN
Conditions: Ventricular Tachycardia
Interventions: PROCEDURE: Strategy 1 - endocardial ablation|PROCEDURE: Strategy 2 - endocardial and epicardial ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility of SurModics SurVeil (TM) Drug Coated Balloon
Status: COMPLETED
Conditions: Peripheral Arterial Disease|Peripheral Vascular Diseases
Interventions: DEVICE: SurVeil Drug Coated Balloon|PROCEDURE: Angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S9630, Medroxyprogesterone in Treating Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Endometrial Cancer
Interventions: DRUG: medroxyprogesterone|DRUG: tamoxifen citrate|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess Relative Bioavailability of Branebrutinib, From a Tablet Formulation to the Capsule Formulation, the Effect of Food on the Bioavailability of Branebrutinib From a Tablet Formulation, and the Safety and Drug Levels of Branebrutinib From a Tablet Formulation in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Branebrutinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Healing Of Nerves Through Electrical Stimulation
Status: RECRUITING
Conditions: Cubital Tunnel Syndrome|Nerve Compression|Nerve Injury|Ulnar Neuropathies
Interventions: DEVICE: Checkpoint BEST System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety/Effectiveness of Oral Chemokine Coreceptor 5 (CCR5) Antagonist INCB009471 in R5-tropic HIV Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: INCB009471|DRUG: INCB009471|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Pharmacokinetic Drug Interactions Between Rosuvastatin and Ezetimibe
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rosuvastatin 20mg|DRUG: Ezetimibe 10mg|DRUG: Rosuvastatin 20mg + Ezetimibe 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of VB10.16 and Pembrolizumab in Patients With Head-Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: HPV Positive Oropharyngeal Squamous Cell Carcinoma|HNSCC
Interventions: BIOLOGICAL: VB10.16|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Validation of a Comprehensive Module for Management of Sleep Disorders in ASD Children
Status: NOT_YET_RECRUITING
Conditions: Sleep Disorder|Autism Spectrum Disorder|Polysomnography|Actigraphy|Children|Behavior Therapy
Interventions: BEHAVIORAL: Comprehensive module for management of sleep disorders[Behavioral and pharmacological therapy]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nurse-led Patient-centered Advance Care Planning: A Pilot Study
Status: COMPLETED
Conditions: Advance Care Planning|Nurse Care Coordination|Multiple Chronic Health Conditions
Interventions: OTHER: Advance Care Planning Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Comparative Study of Scar Quality and Safety According to Suture Materials Following Excision of Benign Tumors
Status: UNKNOWN
Conditions: Scar Quality Assessment and Safety
Interventions: PROCEDURE: multi-layer wound closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Monitoring After Breast Biopsy: Benefit of E-health
Status: COMPLETED
Conditions: Breast Cancer|Biopsy Wound
Interventions: OTHER: phone consultation|OTHER: e-PRO self-completed via connected objects (tablet/phone)|OTHER: phone consultation|OTHER: visit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Isomaltulose VS Sucrose - Postprandial Effect on Incretin Profile and Second Meal Effect
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Intervention A|DIETARY_SUPPLEMENT: Intervention B|DIETARY_SUPPLEMENT: Intervention C|DIETARY_SUPPLEMENT: Intervention D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Analysis of Spread Level During Thoracic Erector Spinae Block
Status: COMPLETED
Conditions: Pain|Radiculopathy, Cervical
Interventions: PROCEDURE: Erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: QUILT-3.006 for Recurrent Medullary Thyroid Cancer
Status: COMPLETED
Conditions: Medullary Thyroid Cancer (MTC)
Interventions: BIOLOGICAL: GI-6207 [Recombinant Saccharomyces cerevisiae-CEA (610D)]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: terbinafine|DRUG: Placebo|DRUG: terbinafine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tissue Sodium in Pre-hypertensive Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Spironolactone|DRUG: Chlorthalidone|DIETARY_SUPPLEMENT: Diet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence of H1N1v Influenza-like Illness and Risk Factors for Serious Influenza Forms in HIV Infected Patients
Status: COMPLETED
Conditions: HIV Infections|Influenza
Interventions: BIOLOGICAL: naso-pharyngeal swab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Aliskiren 300 mg Compared to Telmisartan 80 mg After 1 Week of Treatment Withdrawal
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Aliskiren|DRUG: Telmisartan|DRUG: Placebo to Aliskiren|DRUG: Placebo to Telmisartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cediranib Maleate in Treating Patients With Recurrent or Persistent Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Adenocarcinoma|Endometrial Adenosquamous Carcinoma|Endometrial Clear Cell Adenocarcinoma|Endometrial Serous Adenocarcinoma|Recurrent Uterine Corpus Carcinoma
Interventions: DRUG: Cediranib Maleate|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Exemestane Plus Dasatinib Versus Placebo for Advanced ER+ Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Exemestane + Dasatinib|DRUG: Exemestane + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diet Treatment of Patients With Ulcerative Colitis in Remission
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DIETARY_SUPPLEMENT: Low FODMAP|DIETARY_SUPPLEMENT: Standardized FODMAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Safety, Tolerability and Pharmacokinetic Study of a Single Dose of CMX157 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CMX157|DRUG: Placebo|DRUG: Viread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: MSI-1256F (Squalamine Lactate) in Combination With Verteporfin in Patients With "Wet" Age-Related Macular Degeneration (AMD)
Status: TERMINATED
Conditions: Macular Degeneration
Interventions: DRUG: MSI-1256F (Squalamine Lactate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Antisecretory Factor Glioblastoma Phase 2
Status: RECRUITING
Conditions: Glioblastoma
Interventions: DIETARY_SUPPLEMENT: Salovum|DIETARY_SUPPLEMENT: Placebo egg yolk powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sequential Trial on Reduced Intensity Conditioning (RIC) Allogeneic Transplantation
Status: COMPLETED
Conditions: Hematologic Malignancies|Multiple Myeloma
Interventions: DRUG: Bz (Bortezomib)|DRUG: Len (lenalidomide)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Firi-cel in Patients With Relapsed/Refractory Large B-cell Lymphoma
Status: RECRUITING
Conditions: Cancer|Relapsed/Refractory Large B-cell Lymphoma (LBCL)
Interventions: DRUG: Fludarabine (Conditional therapy)|DRUG: Cyclophosphamide Monohydrate (Conditional therapy)|DRUG: firi-cel (Experimental drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Compare Safety and Effectiveness for Relieving Tenderness of 10% Naproxen Gel vs. a 2.32% Diclofenac Diethylamine Gel in the Treatment of Strains and Bruises of the Legs.
Status: COMPLETED
Conditions: Soft Tissue Injury
Interventions: DRUG: Naproxen gel|DRUG: Diclofenac gel|DRUG: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Can Flowable Bulk Fill Composites be Used in Proximal Area of Class II Restorations
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Restoration Failure of Marginal Integrity
Interventions: PROCEDURE: Restoration with Incremental Composite in Proximal Wall|PROCEDURE: Restoration with Bulk Fill Composite in Proximal Wall
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Metabolic Impact of IRTA© and Patients Satisfaction in Type 1 Diabetic Patients, Treated by Either Insulin Pump or Multiple Daily Insulin Injections, and Using Freestyle Libre®, a Real-time Continuous Glucose Monitoring
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: OTHER: A decision support software
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Circulating Oxidative Stress and Gestational Hypertension. Study of the Evolution of Free-radical Markers of Oxidative Stress From Before to After Childbirth in Two Groups of Women: Normal Pregnancy and Pre-eclampsia.
Status: COMPLETED
Conditions: Pregnancy Complicated by Pre-eclampsia.|Normal Pregnancy
Interventions: OTHER: blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Study Comparing Three Methods of Outpatient Follow up After Surgical Admission; Text Message, Phone Call and In-person Appointment
Status: COMPLETED
Conditions: Outpatients|Virtual Clinic|Text Messaging|General Surgery
Interventions: OTHER: Text message follow up|OTHER: Telephone follow up|OTHER: In person follow up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Open-Label Safety Extension Study in Patients Who Have Previously Participated and Have Benefited From LMIS 50 mg
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: LMIS 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasonography in Juvenile Idiopathic Arthritis
Status: COMPLETED
Conditions: Juvenile Idiopathic Arthritis, Oligoarthritis|Polyarticular Juvenile Rheumatoid Arthritis|Systemic Juvenile Idiopathic Arthritis
Interventions: DEVICE: Ultrasonography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Tramadol, Pethidine and Morphine in the Treatment of Pain After Thoracic Surgery
Status: NOT_YET_RECRUITING
Conditions: Thoracic Diseases|Analgesia
Interventions: DRUG: Tramadol hydrochloride|DRUG: Aldolan|DRUG: Morphine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety, Efficacy and Pharmacokinetics of Venetoclax Combined With Chemotherapy in Participants With B-Cell Non-Hodgkin's Lymphoma (NHL) and DLBCL
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: Venetoclax|DRUG: Cyclophosphamide|DRUG: Obinutuzumab|DRUG: Rituximab|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of PD0332991 (Palbociclib), a Cyclin-dependent Kinase 4 and 6 Inhibitor, in Patients With Oligodendroglioma or Recurrent Oligoastrocytoma Anaplastic With the Activity of the Protein RB Preserved
Status: COMPLETED
Conditions: Oligodendroglioma|Oligoastrocytoma
Interventions: DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of an Interactive 3D Tool During Consultation for Breast Reconstruction Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: OTHER: interactive 3D tool|OTHER: BREAST-Q Reconstruction Module|OTHER: DQI|OTHER: Ottawa Decision Regret Scale
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Exploratory Study to Investigate the Effect of Dapagliflozin and Exenatide Combined on Body Weight
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Dapagliflozin|DRUG: Exenatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Approaches to Correcting Vitamin D Inadequacy and Maintaining Adequacy
Status: COMPLETED
Conditions: Vitamin D Inadequacy|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol (vitamin D3)|DIETARY_SUPPLEMENT: Ergocalciferol (vitamin D2)|DIETARY_SUPPLEMENT: Ergocalciferol (vitamin D2)|DIETARY_SUPPLEMENT: Cholecalciferol (vitamin D3)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Axl/Mer/CSF1R Selective Tyrosine Kinase Inhibitor Q702 in Combination With Pembrolizumab in Patients With Selected Advanced Solid Tumors
Status: RECRUITING
Conditions: Esophageal Cancer|Gastric Cancer|Hepatocellular Cancer|Cervical Cancer
Interventions: DRUG: Q702|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Plasma Rich in Growth Factors (PRGF-Endoret) Eye-drops in the Treatment of Neurotrophic Keratitis
Status: UNKNOWN
Conditions: Neurotrophic Keratitis
Interventions: DRUG: PRGF-Endoret|DRUG: Artificial tears eye-drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of a Pre-Surgical Toolkit in Improving Surgical Care and Outcomes in Older Participants With Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Neoplasm|Surgical Procedure, Unspecified|Health Care Provider|Carcinoma
Interventions: OTHER: Best Practice|OTHER: Informational Intervention|OTHER: Questionnaire Administration|OTHER: Informational Intervention with Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Randomized Trial to Assess Efficacy of PUFA for the Maintenance of Sinus Rhythm in Persistent Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DIETARY_SUPPLEMENT: Omega 3 (n-3 PUFA)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Identification of Clostridium Butyricum and Clostridium Neonatal in the Digestive Microbiota of Premature Infants Before 34 Weeks and Developing or Not Ulcerative Necrotizing Enterocolitis (NEC) During Hospitalization
Status: RECRUITING
Conditions: Necrotizing Enterocolitis
Interventions: OTHER: Stool sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sex Steroids and the Serotonin Transporter
Status: COMPLETED
Conditions: Transsexualism
Interventions: DRUG: Testolactone undecanoate|DRUG: Lynestrenol|DRUG: Cyproterone Acetate|DRUG: Estradiol|DRUG: 5-alpha reductase inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Opioid-Induced Swallowing Dysfunction - The Impact of Bolus Volume
Status: UNKNOWN
Conditions: Pharyngeal Dysfunction|Pharyngeal Swallowing
Interventions: DRUG: RemifentanilMNTX|DRUG: PlaceboMNTX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Comparing Two Types of Supportive Interventions for Caregivers of Patients With Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer Patients|Family Caregivers
Interventions: OTHER: Cognitive Behavioral Therapy for Cancer Caregivers (CBT-C)|OTHER: Emotion Regulation Therapy for Cancer Caregivers (ERT-C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Educational Program Plus Physiotherapy After Prostatectomy
Status: UNKNOWN
Conditions: Prostate Cancer|Side Effects
Interventions: BEHAVIORAL: Therapeutic educational program|OTHER: PFMT|OTHER: TTNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study With CIN-107 Following Multiple Oral Ascending Doses in Healthy Subjects
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: CIN-107|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of High Flow Oxygen Therapy in Patients With Hematologic Malignancy Acute Hypoxemic Respiratory Failure
Status: COMPLETED
Conditions: Acute Hypoxemic Respiratory Failure|Hematologic Malignancy
Interventions: DEVICE: High flow oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn How Safe the Study Treatment BAY2701250 is, How it Affects the Body and How it Moves Into, Through and Out of the Body in Healthy Male Participants When a Single Amount is Given as an Injection Into the Vein (Intravenous Infusion) or Under the Skin (Subcutaneous Injection)
Status: RECRUITING
Conditions: Pulmonary Hypertension Due to Left Heart Disease
Interventions: DRUG: BAY2701250 IV|DRUG: Placebo IV|DRUG: BAY2701250 SC|DRUG: Placebo SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Usefulness of Lidocaine in Oral and Maxillofacial Surgeries Under General Anesthesia for Pain Control After Operation
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Lidocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fasting Study of Oxycodone Hydrochloride 15 mg Tablets and Roxicodone™ 15 mg Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxycodone hydrochloride tablet 15 mg|DRUG: Roxicodone™ tablet 15 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: GTSCOPE - To Evaluate the Natural Progression of Dry Age-related Macular Degeneration (AMD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Dry Age-related Macular Degeneration|Macular Degeneration|Retinal Disease|Retinal Degeneration|Geographic Atrophy|Macular Atrophy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of PBK-1701TC for Bowel Cleansing Before Colonoscopy
Status: COMPLETED
Conditions: Colonic Diseases|Intestinal Disease|Gastrointestinal Disease|Digestive System Disease
Interventions: DRUG: PBK-1701TC|DRUG: Standard oral preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect on Xpert® Bladder Test of Urines Inflammatory Milieu Induced by BCG Treatment of Patients With NMIBC
Status: UNKNOWN
Conditions: Non Muscle Invasive Bladder Cancer|Treatment by BCG
Interventions: BIOLOGICAL: Xpert bladder Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: DynamX Sirolimus Study Sirolimus Eluting Coronary Bioadaptor System
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: DynamX Sirolimus-eluting Coronary Bioadaptor System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CM310 Injection in Subjects With Moderate-to-Severe Atopic Dermatitis
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: CM310
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radial Extracorporeal Shockwave Therapy Combined With Evidence-Based Physical Therapy for Adhesive Capsulitis
Status: COMPLETED
Conditions: Adhesive Capsulitis of Shoulder
Interventions: OTHER: radial extracorporeal shockwave therapy+ evidence-based physical therapy|OTHER: sham radial extracorporeal shockwave therapy+ evidence-based physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Investigating Bone Cement With or Without Inossia™ Cement Softener for Vertebral Compression Fractures
Status: RECRUITING
Conditions: Vertebral Compression Fracture
Interventions: DEVICE: V-Flex|DEVICE: V-Steady
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Bevel Direction on the Pathway of the Nasotracheal Tube
Status: COMPLETED
Conditions: Epistaxis|Intubation Complication
Interventions: PROCEDURE: Bevel facing the cephalad direction of the patient|PROCEDURE: Bevel facing leftward of the patient
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prospective Treatment Efficacy in IPF Using Genotype for Nac Selection (PRECISIONS) Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: N-acetyl cysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PTNS Versus Sham Efficacy in Treatment of BPS
Status: COMPLETED
Conditions: Interstitial Cystitis Bladder Pain Syndromes
Interventions: DEVICE: NURO TM|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of and Immune Response to Two Different Dengue Virus Vaccines in Individuals Previously Immunized Against Dengue Virus
Status: COMPLETED
Conditions: Dengue Hemorrhagic Fever
Interventions: BIOLOGICAL: rDEN1delta30|BIOLOGICAL: rDEN2/4delta30(ME)|BIOLOGICAL: Placebo to rDEN1delta30 or rDEN2/4delta30(ME)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Patients With Metastatic Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: Elacestrant|DRUG: Alpelisib|DRUG: Everolimus|DRUG: Ribociclib|DRUG: Palbociclib|DRUG: Capivasertib|DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction Chemotherapy and Toripalimab for Larynx Preservation in Resectable Laryngeal/Hypopharyngeal Carcinoma
Status: RECRUITING
Conditions: Laryngeal Cancer|Hypopharynx Cancer|Laryngeal Neoplasms
Interventions: DRUG: chemotherapy TP regimen combined with Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AlloGen-LI Treatment of Spinal Stenosis
Status: WITHDRAWN
Conditions: Low Back Pain
Interventions: DRUG: AlloGen-LI|DRUG: depomedrol|DEVICE: MRI|DRUG: 0.5% marcaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Safety and Efficacy Study of I.V. Iclaprim v Linezolid in cSSSI (ASSIST-1)
Status: COMPLETED
Conditions: Complicated Skin and Skin Structure Infection
Interventions: DRUG: intravenous iclaprim or intravenous linezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Role of the Pharmacist and Pharmacogenomics in the Care of Seriously Ill Patients
Status: TERMINATED
Conditions: Palliative Medicine
Interventions: DIAGNOSTIC_TEST: Pharmacogenomics testing|OTHER: Pharmacist review
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Efficacy of Qingxin Zishen Decoction in Treating Menopausal Syndrome and Neuroendocrine Mechanism of Regulating KNDy Neurons
Status: COMPLETED
Conditions: Menopause
Interventions: DRUG: Femoston|DRUG: Qingxin Zishen Decoction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-Obturation Pain Following the Use of the AH Plus and iRoot SP Sealers
Status: COMPLETED
Conditions: Endodontically-Treated Teeth
Interventions: OTHER: Root canal obturation with iRoot SP sealer|OTHER: Root canal obturation with AH Plus Sealer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dose, Safety, Tolerability and Immunogenicity of an Influenza H1 Stabilized Stem Ferritin Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Influenza Infection
Interventions: BIOLOGICAL: VRC-FLUNPF099-00-VP (H1ssF_3928)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Safety and Pharmacokinetics of a Single Dose of VH3810109 (Also Known as GSK3810109), Administered Either Subcutaneously (SC) With rHuPH20 or Intravenously (IV), in Healthy Adult Participants
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: VH3810109|BIOLOGICAL: rHuPH20
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Dexmedetomidine and Glycopyrrolate Therapy
Status: WITHDRAWN
Conditions: Bladder Irritable
Interventions: DRUG: Glycopyrrolate + dexmedetomidine|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sedation Administration Timing: Intermittent Dosing Reduces Time to Extubation
Status: UNKNOWN
Conditions: Respiration, Artificial|Postoperative Pain|Postoperative Complications
Interventions: OTHER: Intermittent Dosing of Medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Canephron® N in the Management of Uncomplicated Urinary Tract Infections (uUTI)
Status: COMPLETED
Conditions: Urinary Tract Infection
Interventions: DRUG: Canephron® N
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of an Adhesive Overlay on the Delivery of Contraceptive Hormones From ORTHO EVRA® in Healthy Women
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Treatment A: ORTHO EVRA patch (NGMN + EE) with an adhesive overlay|DRUG: Treatment B: ORTHO EVRA patch (NGMN + EE) without an overlay
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Collecting Stress Biomarkers Among Youth Experiencing Homelessness
Status: COMPLETED
Conditions: Stress, Physiological
Interventions: BEHAVIORAL: Virtual Reality with Meditation|BEHAVIORAL: Audio Control|BEHAVIORAL: Virtual reality Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of RoActemra/Actemra (Tocilizumab) in Combination With DMARDs Versus Current Best Practice DMARD Therapy in Patients With Rheumatoid Arthritis
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tocilizumab [RoActemra/Actemra]|DRUG: DMARD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Topical Putrescine (Fibrostat) for Prevention of Hypertrophic Scars in Mammoplasty Patients
Status: COMPLETED
Conditions: Hypertrophic Scar
Interventions: DRUG: 1,4-Diaminobutane|DRUG: 10% Urea cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: ED50 of Intratecal Prilocaine in Ultrasound Fusion Prostate Biopsy
Status: RECRUITING
Conditions: Evaluate Requirements of 2% Prilocaine in MR-UF Prostate Biopsy
Interventions: DRUG: Dose of prilocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Point of Care RandOmisation Systems for Performing Embedded Comparative Effectiveness Trials Of Routine Treatments
Status: RECRUITING
Conditions: Atrial Fibrillation New Onset|Magnesium Deficiency
Interventions: OTHER: Electronic Point of Care Randomisation tool|DRUG: Magnesium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Multimodal Investigation of Post COVID-19 in Females
Status: COMPLETED
Conditions: Post COVID-19|Cognitive Dysfunction
Interventions: DEVICE: Parasym Device (of Parasym Ltd, UK) using Transcutaneous Vagus Nerve Stimulation (t-VNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Double-Blind Placebo Controlled Trial of Riluzole in Bipolar Depression
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Riluzole|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TAASS-Traumeel Ointment and Gel Compared With a Topical NSAID in Athletes With Acute Ankle Sprain
Status: COMPLETED
Conditions: Sprain of Ankle
Interventions: DRUG: Traumeel S ointment|DRUG: Traumeel S gel|DRUG: Diclofenac gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 18F-DOPA-PET in Planning Surgery in Patients With Gliomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Glioma|Recurrent Brain Neoplasm
Interventions: PROCEDURE: Biopsy|PROCEDURE: Computed Tomography|PROCEDURE: Diffusion Weighted Imaging|DRUG: Fluorine F 18 Fluorodopa|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Perfusion Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC