pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: CMAB009 Combined With FOLFIRI First-line Treatment in Patients With RAS/BRAF Wild-type, Metastatic Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: CMAB009|DRUG: Irinotecan|DRUG: Folinic acid|DRUG: 5-fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Lung Fluid Responsiveness During Hysterectomy
Status: COMPLETED
Conditions: Fluid Overload
Interventions: DRUG: 30 ml/Kg/h crystalloid|DRUG: 10 ml/Kg/h crystalloid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pilot Study of Zirconium-89 Bevacizumab Positron Emission Tomography for Imaging Angiogenesis in Patients With Inflammatory Breast Carcinoma Receiving Preoperative Chemotherapy
Status: COMPLETED
Conditions: Inflammatory Breast Carcinoma
Interventions: DRUG: 89Zr-bevacizumab|PROCEDURE: FDG-PET/CT|PROCEDURE: MRI scan|PROCEDURE: Tumor biopsies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Optical Transcutaneous Sensors of Capnia and Oxygenation
Status: COMPLETED
Conditions: Blood Gas Monitoring, Transcutaneous
Interventions: DEVICE: Measurements of capnia and tissue oxygenation by optical transcutaneous sensors
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparing Single Dose and Multiple Dose of Dexamethasone Post TKA
Status: RECRUITING
Conditions: Osteo Arthritis Knee|Pain, Postoperative
Interventions: DRUG: Dexamethasone before surgery|DRUG: Dexamethasone before and 12 hours after surgery|DRUG: Dexamethasone before and 24 hours after surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemtuzumab Ozogamicin, Fludarabine, and Total-body Irradiation Followed by Peripheral Stem Cell or Bone Marrow Transplantation in Treating Patients With Advanced Acute Myeloid Leukemia or Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: cyclosporine|DRUG: fludarabine phosphate|DRUG: gemtuzumab ozogamicin|DRUG: methotrexate|DRUG: mycophenolate mofetil|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of IL-22 IgG2-Fc (F-652) for Subjects With Grade II-IV Lower GI aGVHD
Status: COMPLETED
Conditions: Acute Graft vs Host Disease
Interventions: DRUG: Recombinant Human Interleukin-22 IgG2-Fc (F-652)|DRUG: Systemic Corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tocotrienol in Combination With Neoadjuvant Chemotherapy for Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Epirubicin 90 mg/m2 iv|DRUG: Cyclophosphamide 600 mg/m2 iv|DRUG: Docetaxel 100 mg/m2 iv OR paclitaxel 80 mg/m2 iv|DRUG: Trastuzumab 8 mg/kg iv saturation, then 6 mg/kg iv (HER2 positive patients only)|DRUG: Pertuzumab 840 mg iv saturation, then 420 mg iv (selected HER2 positive patients only)|DIETARY_SUPPLEMENT: Tocotrienol 300 mg x 3 daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of LGH447 in Japanese Patients With Relapsed and/or Refractory Hematologic Malignancies
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: LGH447
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Toxicities of PLX038, in Patients With Locally Advanced or Metastatic Triple-negative Breast Cancer
Status: RECRUITING
Conditions: Breast|Cancer
Interventions: DRUG: PLX038
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single and Multiple Ascending Doses Study to Evaluate the Safety and Pharmacokinetics of RBD5044
Status: RECRUITING
Conditions: Health Volunteer
Interventions: DRUG: RBD5044|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Effect of Animal and Vegetable Protein Rich Meals With Comparable Dietary Fibers Content on Appetite Sensation and Energy Intake
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: Acute effect of animal and vegetable protein rich meals with comparable dietary fibers content on appetite sensation and energy intake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Placebo or Bosentan to Treat Patients With Single Ventricle Physiology.
Status: COMPLETED
Conditions: Hypoplastic Left Heart Syndrome|Tricuspid Atresia|Other Specified Congenital Anomalies of Heart
Interventions: DRUG: Bosentan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Dose-response of Udenafil in Patients With Benign Prostatic Hyperplasia and Erectile Dysfunction
Status: WITHDRAWN
Conditions: Erectile Dysfunction|Benign Prostatic Hyperplasia
Interventions: DRUG: Udenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Cognition on Activity and Participation in People With Stroke
Status: RECRUITING
Conditions: Stroke|Cognitive Change|Neurological Injury|Cognitive Impairment|Activity, Motor
Interventions: BEHAVIORAL: Ageless Grace
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraosseous vs. Intravenous Vancomycin Administration in Total Ankle Arthroplasty
Status: RECRUITING
Conditions: Infections|Ankle Arthritis
Interventions: DRUG: Intraosseous Vancomycin Injection|DRUG: Intravenous Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two NN5401 Formulations Versus Biphasic Insulin Aspart 30, All in Combination With Metformin in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec/insulin aspart|DRUG: insulin degludec/insulin aspart|DRUG: biphasic insulin aspart|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Extended Cannabis Abstinence on PTSD Symptoms
Status: RECRUITING
Conditions: PTSD|Cannabis Use|Cognitive Symptom|Comorbidities and Coexisting Conditions
Interventions: BEHAVIORAL: Contingency-management|OTHER: Enhanced usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Switching From Cigarette Smoking to the Use of IQOS on Periodontitis Treatment Outcome
Status: COMPLETED
Conditions: Periodontal Diseases|Chronic Periodontitis|Periodontal Pocket|Tooth Mobility|Gingival Diseases|Smoking, Cigarette
Interventions: OTHER: IQOS|OTHER: Cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Paracervical Versus Intracervical Lidocaine
Status: COMPLETED
Conditions: Abortion, Induced|Pain
Interventions: PROCEDURE: Paracervical block|PROCEDURE: Intracervical|DRUG: Buffered Lidocaine, vasopressin, sodium bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Toripalimab Combined With Chemotherapy in Primary Tracheal Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Tracheal Squamous Cell Carcinoma
Interventions: DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Versus Magnesium Sulphate Added to Bupivacaine in Infraorbital Nerve Block for Perioperative Analgesia in Paediatric Patients for Cleft Lip Surgery
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: Dexmedetomidine +Bupivacaine|DRUG: Magnesium Sulfate + Bupivacaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyaluronic Acid for the Treatment of Damaged Nipples in Breastfeeding Women
Status: RECRUITING
Conditions: Cracked Nipple|Breastfeeding|Healing Wound
Interventions: DRUG: Treatment of damaged nipple skin: Preparation with hyaluronic acid|DRUG: Treatment of damaged nipple skin: Neutral preparation without hyaluronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Below the Belt: Non-invasive Neuromodulation to Treat Bladder, Bowel, and Sexual Dysfunction Following Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries|Neurogenic Bladder|Neurogenic Bowel|Spinal Cord Stimulation|Sexual Dysfunction, Physiological
Interventions: DEVICE: Transcutaneous Spinal Cord Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parasympathetic Augmentation Via Respiratory Training for Patients With Systolic Heart Failure
Status: ENROLLING_BY_INVITATION
Conditions: Diastolic Heart Failure
Interventions: BEHAVIORAL: Meo Health Breathing and humming exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Herbal Pralines - Oral Health
Status: COMPLETED
Conditions: Periodontitis|Gingivitis
Interventions: DIETARY_SUPPLEMENT: herbal nitrate Pralines with nitrate|DIETARY_SUPPLEMENT: herbal nitrate Pralines without nitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The PEBBLES Study - Testing a Strategy for Preventing Eczema and Food Allergy in High Risk Infants
Status: ACTIVE_NOT_RECRUITING
Conditions: Eczema|Asthma|Allergy;Food
Interventions: DRUG: EpiCeram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vorinostat in Combination With Palliative Radiotherapy for Patients With Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: Vorinostat|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dialogue Around Respiratory Illness Treatment
Status: UNKNOWN
Conditions: Respiratory Disease|Acute Respiratory Infection|Respiratory Infection|Upper Respiratory Infection
Interventions: OTHER: Online Tutorial|OTHER: Webinars|OTHER: Booster Sessions|OTHER: Feedback Reports|OTHER: Parent Survey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Denileukin Diftitox in Participants With Stage IIIC and Stage IV Melanoma
Status: COMPLETED
Conditions: Stage IIIC Melanoma|Stage IV Melanoma
Interventions: DRUG: Denileukin diftitox
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Augmented Reality-based Rapid Blood Transfusion (Level-1®)
Status: COMPLETED
Conditions: Equipment and Supplies|Augmented Reality|Nurse's Role
Interventions: OTHER: AR-based Training with Microsoft HoloLens 2®|OTHER: Traditional Guideline-based Self-Learning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neovaginoplasty Using Photoinduced-imine-crosslink Hydrogel in MRKH Patients
Status: NOT_YET_RECRUITING
Conditions: Mayer Rokitansky Kuster Hauser Syndrome
Interventions: PROCEDURE: neovaginoplasty and vaginal mold spreaded with photoinduced-imine-crosslink hydrogel|PROCEDURE: neovaginoplasty and vaginal mold
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-Epitope TARP Peptide Autologous Dendritic Cell Vaccination in Men With Stage D0 Prostate Cancer
Status: TERMINATED
Conditions: Prostatic Neoplasms|Prostate Cancer
Interventions: BIOLOGICAL: Autologus elutriated monocyte placebo vaccine|BIOLOGICAL: Multi-epitope (ME) T-cell receptor g alternate reading frame protein (TARP) vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of Self-visualization of Epileptic Seizures on Patients' Perception of the Disease and Risk Behavior
Status: COMPLETED
Conditions: Epilepsy|Epilepsy; Seizure|Risk Behavior|Risk-Taking
Interventions: PROCEDURE: own seizures visualization
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial Comparing Three Single Dose Injections for Knee Osteoarthritis
Status: TERMINATED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Zilretta|DRUG: Synvisc-One 48 MG in 6 ML Prefilled Syringe|DRUG: Monovisc 88 MG Per 4 ML Prefilled Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ologen® Collagen Matrix in Patients With Primary Congenital Glaucoma Undergoing Trabeculectomy
Status: COMPLETED
Conditions: Primary Congenital Glaucoma|Developmental Glaucoma|Infantile Glaucoma
Interventions: PROCEDURE: CTT with ologen® Collagen Matrix|PROCEDURE: Trab Trab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Placebo Controlled Metformin and Sulfonylurea Combination Study in Patients With Type 2 Diabetes (0767-025)
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: MK0767
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 68Ga-PSMA PET/CT in Detecting Prostate Cancer Recurrence in Patients With Elevated PSA After Initial Treatment
Status: COMPLETED
Conditions: Prostate Adenocarcinoma|PSA Failure|Recurrent Prostate Carcinoma
Interventions: PROCEDURE: Computed Tomography (CT) scan|DRUG: 68Ga-PSMA-11|PROCEDURE: Positron Emission Tomography (PET)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study Of Avelumab In Combination With Axitinib In Advanced Renal Cell Cancer (JAVELIN Renal 100)
Status: COMPLETED
Conditions: Renal Cell Cancer
Interventions: DRUG: Avelumab (MSB0010718C)|DRUG: Axitinib (AG-013736)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Explore the Efficacy and Safety of FMT With Different Bacterial Doses in the Treatment of Hepatic Encephalopathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatic Encephalopathy
Interventions: OTHER: Fecal Microbiota Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nutrition for Asthmatics With Obesity
Status: RECRUITING
Conditions: Asthma|Obesity
Interventions: OTHER: DGA Diet|OTHER: MCT Diet|OTHER: KETO Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Blood Pressure, Heart Rate Variability & Sleep in Veterans With PTSD
Status: TERMINATED
Conditions: Insomnia|Posttraumatic Stress Disorder|Hypertension|Cardiovascular Disease
Interventions: BEHAVIORAL: Cognitive-Behavioral Therapy for Insomnia (CBTI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-Third Party T Lymphocytes With Nonmyeloablative Stem Cell Transplantation for Indolent Lymphoid Malignancies
Status: TERMINATED
Conditions: Leukemia|Lymphoma|Myeloma
Interventions: DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Mesna|RADIATION: Radiation Treatment|PROCEDURE: Stem Cell Transplantation (SCT)|DRUG: Sirolimus|PROCEDURE: Anti-third Party Cytolytic T-lymphocytes (CTL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An ACE Inhibitor (Perindopril) or an Angiotensin Receptor Blocker (Candesartan) as a Treatment for Methamphetamine Dependence
Status: COMPLETED
Conditions: Methamphetamine Dependence|Methamphetamine Abuse|Substance Abuse
Interventions: DRUG: Perindopril|DRUG: Placebo|DRUG: Candesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pharmacodynamic and Safety of MT10107(Botulinum Type A Neurotoxin) in Comparison to BOTOX®
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: MT10107|DRUG: Botox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Double Blind Randomized Trial to Compare Gurmar (Gymnema Sylvestre) With Metformin in Type 2 Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Gurmar|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Anesthesia and Lymphocytes Apoptosis
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Sevoflurane|DRUG: Propofol|DRUG: combine of sevoflurane and propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Prospective, Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Symptomatic CD Patients
Status: TERMINATED
Conditions: Celiac Disease
Interventions: DRUG: Latiglutenase|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: INITIATE Plus (INITiation of Insulin to Reach A1c TargEt) Study
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart|BEHAVIORAL: dietary regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Determine the Safety and Immunogenicity of an Oral Whole Cell ShanChol Cholera Vaccine in Bangladesh
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: ShanChol Cholera Vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of the Classic Face Mask Versus NuMask for Preoxygenation
Status: UNKNOWN
Conditions: Inspired Oxygen (FIO2), End-tidal Oxygen (ETO2), End-tidal Carbon Dioxide (ETCO2) and Respiratory Rate (RR) Will be Measured Every 30 Seconds
Interventions: DEVICE: Classic Face Mask and NuMask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Vitamin D in Patients With Stage I-III Colon Cancer or Resectable Colon Cancer Liver Metastases
Status: RECRUITING
Conditions: Stage, Colon Cancer|Stage I-III Colon Cancer|Stage IV Colon Cancer With Resectable Liver Metastases
Interventions: DRUG: Vitamin D3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Meglimine Sodium Succinate for Correction of Metabolic Acidosis in Critically Ill Patients
Status: COMPLETED
Conditions: Metabolic Acidosis
Interventions: DRUG: Meglumine Sodium Succinate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Compare the Efficacy of Microwave Ablation and Laparoscopic Hepatectomy for Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: Percutaneous microwave ablation, Laparoscopic hepatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Guided ACT and for Adults With ASD
Status: UNKNOWN
Conditions: Autism Spectrum Disorder (ASD)
Interventions: OTHER: Acceptance and Commiment Therapy (ACT) bibliotherapy 'Get Out of Your Mind and Into Your Life'
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: INvestigating SIGnificant Health TrendS in the Management of Superficial Vein Thrombosis
Status: COMPLETED
Conditions: Superficial Vein Thrombosis
Interventions: DRUG: any drug|PROCEDURE: any procedure/surgery|OTHER: Any non-pharmacological treatment of SVT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intravenous Doses of CM-101 as a Treatment for Medical Conditions Involving Inflammatory and Fibrotic Mechanisms in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Anti-human CCL24 monoclonal antibody (CM-101)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Nicotine Replacement Therapy (NRT) Sample and Brief Smoking Cessation Advice for Recruiting Smokers
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Nicotine replacement therapy (NRT) sampling|BEHAVIORAL: Medication counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated Proton Beam Therapy for Localized Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage I Prostate Adenocarcinoma AJCC v7|Stage II Prostate Adenocarcinoma AJCC v7
Interventions: OTHER: Laboratory Biomarker Analysis|RADIATION: Proton Beam Radiation Therapy|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of OBT076 Associated or Not in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma of the Head and Neck
Status: SUSPENDED
Conditions: Adenoid Cystic Carcinoma of the Head and Neck
Interventions: DRUG: OBT076|DRUG: Balstilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VX-950HEP1001 - Drug-drug Interaction Study Between Telaprevir and Raltegravir
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Treatment sequence AB|DRUG: Treatment sequence BA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extension Study of an Investigational Drug, Lumasiran (ALN-GO1), in Participants With Primary Hyperoxaluria Type 1
Status: COMPLETED
Conditions: PH1|Primary Hyperoxaluria|RNAi Therapeutic|siRNA|AGT
Interventions: DRUG: Lumasiran
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Medication-Related Problems in Care Transitions to Skilled Nursing Facilities
Status: ACTIVE_NOT_RECRUITING
Conditions: Care Transition
Interventions: OTHER: Structured hand-off|OTHER: Medication reconciliation during transitional period|OTHER: Transitional medication monitoring|OTHER: Teleconsultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Glutaminergic Transmission in Autism : Molecular Imaging Exploration
Status: COMPLETED
Conditions: Autism|Fragile-X Syndrome (FXS)|Healthy Volunteers
Interventions: DRUG: [18F]FPEB PET imaging|OTHER: Biological samples|OTHER: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficiency of Fractional-Laser Resurfacing Followed by Topical Tacrolimus 0.03% Cream vs Tacrolimus Alone in Vitiligo
Status: COMPLETED
Conditions: Stable Vitiligo
Interventions: DEVICE: fractional carbon dioxide laser|DRUG: Tacrolimus Oint 0.03%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: HER2-positive Breast Cancer With Brain Metastasis (GCC 1345)
Status: WITHDRAWN
Conditions: Breast Cancer With Brain Metastasis
Interventions: RADIATION: Stereotactic Radiosurgery plus HER-2 directed therapy in HER2-positive Breast Cancer with Brain Metastasis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Evaluation of Strategies to Improve Sedation Quality in InTensive Care
Status: COMPLETED
Conditions: Critical Illness
Interventions: OTHER: Bespoke on-line sedation education package|OTHER: Sedation specific outcome process feedback|DEVICE: Responsiveness monitoring; novel sedation monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Does Early Administration of Tranexamic Acid Reduce Blood Loss and Perioperative Transfusion Requirement
Status: COMPLETED
Conditions: Hip Fractures|Intertrochanteric Fractures
Interventions: DRUG: Tranexamic Acid (TXA)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ascending Dosages of Moxidectin and Moxidectin-albendazole Against Trichuris Trichiura
Status: COMPLETED
Conditions: Trichuris Trichiura; Infection
Interventions: DRUG: Moxidectin 8mg|DRUG: Moxidectin 8 mg + albendazole 400 mg|DRUG: Moxidectin 16 mg|DRUG: Moxidectin 16 mg + albendazole 400 mg|DRUG: Moxidectin 24 mg|DRUG: Moxidectin 24 mg + albendazole 400 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Tranexamic Acid to Reduce Blood Loss in Acetabular Surgery
Status: COMPLETED
Conditions: Acetabular Fractures
Interventions: DRUG: Tranexamic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of PiggyBac Transposon CAR T-cells Targeting CD-19 in Refractory Lupus.
Status: RECRUITING
Conditions: SLE (Systemic Lupus)
Interventions: OTHER: CAR T-cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Late Stent Strut Apposition and Coverage After Drug-Eluting Stent Implantation by OCT in Patients With AMI
Status: UNKNOWN
Conditions: Coronary Artery Disease|Coronary Disease|Myocardial Ischemia|Arterial Occlusive Diseases|Arteriosclerosis|Cardiovascular Diseases|Heart Diseases|Vascular Diseases
Interventions: DEVICE: Everolimus-Eluting stent|DEVICE: Zotarolimus-Eluting stent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Brentuximab Vedotin in Patients With Hodgkin Lymphoma Unsuitable for Chemotherapy Due to Age, Frailty or Co-morbidity
Status: COMPLETED
Conditions: Hodgkin Disease
Interventions: DRUG: Brentuximab Vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study for Nab-paclitaxel Plus Cisplatin vs Gemcitabine Plus Cispatin as First Line Chemotherapy in Advanced Biliary Tract Cancer
Status: UNKNOWN
Conditions: Biliary Tract Cancer
Interventions: DRUG: Nab-paclitaxel + Cisplatin|DRUG: Gemcitabine + Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Diode Laser (940nm) on Orthodontics
Status: UNKNOWN
Conditions: Low Level Laser Therapy|Pain|Crowding, Tooth
Interventions: PROCEDURE: Low level laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Application of Hyperspectral Imaging in the Diagnosis of Glomerular Diseases
Status: NOT_YET_RECRUITING
Conditions: Glomerulonephritis, IGA|Glomerulonephritis, Membranous|Diabetic Nephropathies|Nephrosis, Lipoid|Hyperspectral Imaging
Interventions: DIAGNOSTIC_TEST: Microscopic hyperspectral imaging system
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Omalizumab on Expression of IgE Receptors in Adults With Severe, Inadequately Controlled Allergic Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Omalizumab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Nutritional Status Associated With Delayed Discharge in Elderly Patients Undergoing Gastrectomy
Status: NOT_YET_RECRUITING
Conditions: Preoperative Nutritional Status and Risk Factors Associated With Elderly Patients Undergoing Gastrectomy
Interventions: OTHER: Clinical data collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Humoral and T-Cell Responses to COVID-19 Vaccination in Multiple Sclerosis Patients Treated With Ocrelizumab Treated With Ocrelizumab or Natalizumab
Status: COMPLETED
Conditions: Multiple Sclerosis|Demyelinating Autoimmune Diseases, CNS|Autoimmune Diseases of the Nervous System|Nervous System Diseases|Demyelinating Diseases|Autoimmune Diseases|Immune System Diseases|Pathologic Processes
Interventions: DEVICE: Elecsys semi-quantitative Anti-SARS-CoV-2 antibody test|DEVICE: T-Detect COVID T-cell blood test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of BCI-838 and Several BCI-632 Prodrugs in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BCI-838|DRUG: BCI-838|DRUG: BCI-1038, BCI-1206 & BCI-1283|DRUG: BCI-838
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Two Schedules of Hepatitis B Vaccination in Predialysis Chronic Renal Failure Patients
Status: COMPLETED
Conditions: Renal Failure
Interventions: BIOLOGICAL: four doses of Euvax B vaccine|BIOLOGICAL: 20 μg (1 ml) three doses of Euvax B vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: SBRT Combined With Thymalfasin for Metastatic Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Cancer|Metastatic Esophageal Cancer|Stereotactic Body Radiation Therapy|Thymalfasin
Interventions: RADIATION: Stereotactic Body Radiation Therapy|DRUG: Thymalfasin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-marketing Surveillance of Donepezil Hydrochloride Investigation of the Safety and Effectiveness of Combination Therapy of Donepezil Hydrochloride and Memantine Hydrochloride in Patients With Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Desease
Interventions: DRUG: Donepezil Hydrochloride
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Activity at Ventilation Threshold on Appetite and Food Intake in Boys
Status: COMPLETED
Conditions: Obesity Prevention
Interventions: OTHER: Dietary Supplement: water with noncalorie sweetener|OTHER: Activity: With noncalorie sweetener or glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparing the Efficacy and Tolerability of Fulvestrant 500 mg Versus 250 mg in Advanced Breast Cancer Women
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Fulvestrant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Olanzapine Compared to Lamotrigine in the Prevention of Depressive Episode in the Patients With Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Lamotrigine|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mechanisms Underlying the Efficacy of Prolonged Exposure
Status: NOT_YET_RECRUITING
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Prolonged Exposure Therapy for Posttraumatic Stress Disorder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Peginterferon Alfa-2a in Combination With Ribavirin in Chronic Hepatitis C (CHC) Patients With Compensated Liver Cirrhosis (LC)
Status: COMPLETED
Conditions: Liver Cirrhosis|Chronic Hepatitis C
Interventions: DRUG: peginterferon alfa-2a 180μg|DRUG: peginterferon alfa-2a 90μg|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Research on Repair of Massive-large Rotator Cuff Tears
Status: RECRUITING
Conditions: Rotator Cuff Tears
Interventions: PROCEDURE: novel double row|PROCEDURE: suture bridge double row
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Hygiene and Systemic Inflammation (Perio-Hygiene 1.0)
Status: COMPLETED
Conditions: Gingivitis
Interventions: BEHAVIORAL: Oral Hygiene Instruction (OHI)|PROCEDURE: Professional supragingival scaling and polishing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study to Evaluate the Efficacy and Safety of Oral Ceritinib in Patients With ALK-positive NSCLC Metastatic to the Brain and/or to Leptomeninges
Status: COMPLETED
Conditions: ALK-positive Non-small Cell Lung Cancer
Interventions: DRUG: Ceritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lower Body Muscle Pre-activation in Initial Orthostatic Hypotension
Status: UNKNOWN
Conditions: Orthostatic Intolerance|Syncope|Fainting|Presyncope
Interventions: OTHER: Physical Counter-maneuver|OTHER: Stress Test|OTHER: Functional Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy for Prevention of Nonmelanoma Skin Cancer in Organ Transplant Recipients
Status: COMPLETED
Conditions: Nonmelanoma Skin Cancers
Interventions: OTHER: have Levulan Kerastick (aminolevulinic acid) solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/IIa Trial of scAAV1.tMCK.NTF3 for Treatment of CMT1A
Status: SUSPENDED
Conditions: Charcot-Marie-Tooth Neuropathy Type 1A
Interventions: DRUG: scAAV1.tMCK.NTF3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Open-label, Single Dose Study of the Safety and Efficacy of GSK1358820 (Botulinum Toxin Type A) in Chinese Subjects With Post-stroke Focal Upper Limb Spasticity
Status: COMPLETED
Conditions: Spasticity, Post-Stroke
Interventions: DRUG: Botulinum toxin type A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paratracheal Esophagus Pressure on the Intubation With Pentax Airway Scope
Status: COMPLETED
Conditions: Anesthesia|Intubation; Difficult or Failed|Cricoid Pressure|Pulmonary Aspiration During Anesthetic Induction
Interventions: PROCEDURE: Paratracheal pressure|PROCEDURE: Cricoid pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Active Video-game Playing and Food Intake in Children
Status: COMPLETED
Conditions: Appetitive Behavior
Interventions: BEHAVIORAL: Glucose beverage, control beverage, glucose beverage and active video game playing, control beverage and active video game playing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Towards Understanding the Phenotype of Cardiovascular Disease in CKD - TRUE-Type-CKD Study
Status: COMPLETED
Conditions: Heart Failure|Cardiomyopathies|Chronic Kidney Diseases|Hypertrophy, Left Ventricular
Interventions: DIAGNOSTIC_TEST: cardiac magnetic resonance (CMR) post haemodialysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Investigate the Anti-Plaque Effect of AN0128 Toothpaste
Status: COMPLETED
Conditions: Dental Plaque
Interventions: OTHER: Negative Control (Regular Toothpaste)|OTHER: Positive Control (anti-plaque/anti-bacterial toothpaste)|DRUG: Prototype (AN0128 Toothpaste)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PSMA Imaging of Localized Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: 89ZR-DF-IAB2M|DRUG: 68Ga-PSMA-HBED-CC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase Ib Feasibility Trial of Neoadjuvant Nivolumab/Lirilumab in Cisplatin-Ineligible Muscle-Invasive Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: Nivolumab|DRUG: Nivolumab/Lirilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuroaxial Labour Analgesia
Status: COMPLETED
Conditions: Labor Analgesia
Interventions: PROCEDURE: Dural Puncture Epidural Technique|PROCEDURE: Combined Spinal Epidural without intrathecal opioids|PROCEDURE: epidural
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose Study of MK-5160 in Participants With Type 1 and Type 2 Diabetes Mellitus (MK-5160-002)
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus
Interventions: BIOLOGICAL: MK-5160 16 nmol/kg|BIOLOGICAL: MK-5160 32 nmol/kg|BIOLOGICAL: MK-5160 64 nmol/kg|BIOLOGICAL: Glargine 0.4 U/kg|BIOLOGICAL: Placebo to Glargine|BIOLOGICAL: Placebo to MK-5160|DRUG: Dextrose|BIOLOGICAL: Glargine 0.6 U/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Breath-hold Cardiac Hybrid SPECT/CCTA
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Breathhold SPECT-MPI|DEVICE: Standard freebreathing SPECT-MPI|DEVICE: Coronary CT angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Safety of Subcutaneous Alemtuzumab in Patients With B-Cell Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: B-CLL
Interventions: DRUG: alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Lenvatinib for Platinum- Sensitive Recurrent Ovarian Cancer
Status: RECRUITING
Conditions: Ovarian Neoplasms|Carcinoma, Ovarian Epithelial|Neoplasm of Stomach|Ovarian Diseases|Genital Neoplasms, Female|Ovarian Epithelial Tumor|Urogenital Neoplasms|Neoplasms, Glandular and Epithelial
Interventions: DRUG: Pembrolizumab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Systemic Chemotherapy in Combination With Conventional Transarterial Chemoembolization in Patients With Advanced Intra-Hepatic Cholangiocarcinoma
Status: TERMINATED
Conditions: Unresectable Intrahepatic Cholangiocarcinoma
Interventions: DRUG: gemcitabine|DRUG: Cisplatin|DRUG: Conventional TACE (transarterial chemoembolization) with Doxorubicin/Mitomycin-C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aqueous Humor Level of Cytokines in Polypoidal Choroidal Vasculopathy and Change of Cytokines After Photodynamic Therapy
Status: UNKNOWN
Conditions: Polypoidal Choroidal Vasculopathy
Interventions: DRUG: ranibizumab(Lucentis), verteporfin(Visudyne)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Trial of Neoadjuvant Everolimus Plus Letrozole Versus FEC in Women With ER-positive, HER2-negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Everolimus|DRUG: Letrozole|DRUG: Fluorouracil|DRUG: Epirubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of AMG 592 in Healthy Japanese Participants
Status: COMPLETED
Conditions: Chronic Graft-versus-Host Disease (cGVHD)
Interventions: DRUG: AMG 592|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Glaukos® iStent Infinite Trabecular Micro-Bypass System in Subjects With Mild to Moderate Primary Open-angle Glaucoma
Status: RECRUITING
Conditions: Glaucoma
Interventions: DEVICE: iStent Infinite
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Gemlapodect (NOE-105) in Adults and Adolescents With Tourette Syndrome
Status: RECRUITING
Conditions: Tourette Syndrome
Interventions: DRUG: Gemlapodect|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Sirolimus and Methotrexate in Relapsed/Refractory Lymphoblastic Leukemia and Lymphoma
Status: COMPLETED
Conditions: Cancer|Leukemia|Lymphoma
Interventions: DRUG: Sirolimus and Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel, Gemcitabine and Bevacizumab for Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Bevacizumab|DRUG: Docetaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Impact of an Intensive Team-based Intervention on Type 2 Diabetes Reversal
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Moderate-carbohydrate Mediterranean diet, Personalized exercice prescription and training, Intermittent fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of FXR Activation on Hepatic Lipid and Glucose Metabolism
Status: COMPLETED
Conditions: Metabolic Syndrome|Familial Hypertriglyceridemia|Familial Combined Hyperlipidemia
Interventions: DRUG: chenodeoxycholic acid|DRUG: placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT