pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Post-marketing Study of Lyophilized Nasal Spray Live Attenuated Influenza Vaccine
Status: RECRUITING
Conditions: Influenza Prevention
Interventions: BIOLOGICAL: Influenza Vaccine, Live, Nasal, Freeze-dried|OTHER: Sterile water for inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of MK-4464 as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced/Metastatic Solid Tumors (MK-4464-001)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced/Metastatic Solid Tumors|Neoplasms
Interventions: BIOLOGICAL: MK-4464|BIOLOGICAL: Pembrolizumab|DRUG: 89Zr-MK-4464
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Controlled Study of Parent Training in the Treatment of ADHD in Young Children
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: New Forest Parenting Programme|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EUS-FNA Versus KHB in Diagnostics of Upper Gastrointestinal Submucosal Tumors
Status: UNKNOWN
Conditions: Other Specified Disorders of Esophagus, Stomach or Duodenum
Interventions: PROCEDURE: Key Hole Biopsy ( KHB)|PROCEDURE: EUS-FNA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Tobacco Cessation Treatment for Pregnant Alaska Natives
Status: COMPLETED
Conditions: Tobacco Use
Interventions: BEHAVIORAL: Standard intervention (counseling + self-help written materials)|BEHAVIORAL: Enhanced Intervention (same as standard treatment plus 10-15 min of counseling and a culturally tailored video)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Animal Assisted Intervention With Dogs for Children With ADHD
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: Behavioral Social Skills Training|BEHAVIORAL: Animal Assisted Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Late Hypothermia for Hypoxic-Ischemic Encephalopathy
Status: COMPLETED
Conditions: Infant, Newborn|Hypoxia, Brain|Hypoxia-Ischemia, Brain|Encephalopathy, Hypoxic-Ischemic|Hypoxic-Ischemic Encephalopathy|Ischemic-Hypoxic Encephalopathy
Interventions: PROCEDURE: Hypothermia|PROCEDURE: Normothermic Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gonadotropin-releasing Hormone Agonist Prior to Myomectomy
Status: COMPLETED
Conditions: Fibroids
Interventions: DRUG: 2 Doses Goserelin|DRUG: 3 Doses Goserelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Central Versus Peripheral Placement of Local Anesthetic
Status: COMPLETED
Conditions: Hand Surgery|Elbow Surgery|Forearm Surgery|Wrist Surgery
Interventions: PROCEDURE: Peripheral placement of local anesthesia|PROCEDURE: Central placement of local anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Neural Correlates of Personalized Treatment With Transdermal Nicotine Replacement
Status: TERMINATED
Conditions: Tobacco Use Disorder|Nicotine Dependence
Interventions: DRUG: Nicotine patch|DRUG: Nicotine mouthspray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluorescence Image-Guided Lymphadenectomy in Robotic Gastrectomy
Status: UNKNOWN
Conditions: Gastric Cancer|Sentinel Lymph Node
Interventions: PROCEDURE: Image-Guided Robotic Gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Controlled, Double Blind Trial of Eszopiclone for Insomnia Associated With Schizophrenia
Status: COMPLETED
Conditions: Insomnia|Schizophrenia|Schizoaffective Disorder|Sleep Disorders
Interventions: DRUG: Eszopiclone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Beetroot Juice to Protect Against Postoperative Ileus (POI) Following Colorectal Surgery: a Pilot Study.
Status: TERMINATED
Conditions: Postoperative Ileus
Interventions: DIETARY_SUPPLEMENT: Beetroot juice|DIETARY_SUPPLEMENT: Nitrate-depleted beetroot juice|DIETARY_SUPPLEMENT: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of Radion™-Pdt in Patients With Oral Precancerous Lesion
Status: COMPLETED
Conditions: Erythroleukoplakia of Mouth|Verrucous Hyperplasia of Oral Mucosa
Interventions: DRUG: Radion™-pdt
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Myo-inositol and D-chiro-inositol on Oocyte Quality
Status: COMPLETED
Conditions: Infertility
Interventions: DIETARY_SUPPLEMENT: Myo-inositol|DIETARY_SUPPLEMENT: D-chito-Inositol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery
Status: COMPLETED
Conditions: Heart Defects, Congenital|Hypertension, Pulmonary
Interventions: DRUG: L-citrulline|DRUG: Placebo of intravenous L-citrulline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Investigate the Safety/Tolerability and Pharmacokinetics/Pharmacodynamics of CKD-519
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: CKD-519|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Accuracy of LAA Occluder Size Selection: CT vs. DSA During Combined AF Ablation and LAA Occlusion
Status: RECRUITING
Conditions: Atrial Fibrillation|Arrhythmias, Cardiac|Heart Diseases|Cardiovascular Diseases
Interventions: OTHER: CT group|OTHER: DSA group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study to Investigate Efficacy of LAS41004 in a Psoriasis Plaque Test
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: LAS41004|DRUG: reference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Ablative Radiotherapy for Comprehensive Treatment of Oligometastatic Tumors (SABR-COMET)
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Tumors
Interventions: RADIATION: Stereotactic ablative radiotherapy|RADIATION: palliative radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Different Doses of BI 1569912 in People With Depression
Status: NOT_YET_RECRUITING
Conditions: Depressive Disorder, Major
Interventions: DRUG: BI 1569912|DRUG: Placebo matching BI 1569912
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fixation Insitu Versus Removal for Midfoot Lisfranc Injuries
Status: RECRUITING
Conditions: Closed Fracture Dislocation, Tarsometatarsal Joint|Open Fracture Dislocation, Tarsometatarsal Joint
Interventions: PROCEDURE: Hardware removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Race-Based Stress and Cognitive Training for MCI
Status: NOT_YET_RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Race Based Stress and Empowerment Focused Compensatory Cognitive Training for Mild Cognitive Impairment (RBSEF-CCT-MCI)|BEHAVIORAL: Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (ME-CCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Streamline Occipito-Cervico-Thoracic System Post-Market Clinical Follow-up
Status: COMPLETED
Conditions: Spinal Stenosis Occipito-Atlanto-Axial|Spinal Disease|Spinal Stenosis Cervical|Spinal Stenosis Cervicothoracic Region|Spinal Instability
Interventions: DEVICE: Streamline Occipito-Cervico-Thoracic Spinal Fixation System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Two Combination Treatment Regimens of Nivolumab and Ipilimumab in Patients With dMMR and / or MSI mCRC.
Status: RECRUITING
Conditions: Colorectal Cancer Metastatic|MSI-H Colorectal Cancer
Interventions: DRUG: Nivolumab 480mg + Ipilimumab|DRUG: Nivolumab 240 mg + Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Redesigning Patient Handling Tasks to Prevent Nursing Back Injuries
Status: COMPLETED
Conditions: Back Pain|Occupational Diseases
Interventions: DEVICE: Redesigning patient handling tasks using equip: Arjo Bianca Overhead Lift, Hill-Rom Resident Transfer Device, TranSit Chair, Total Care Bed|PROCEDURE: Redesigned patient handling tasks using work practice controls: setting bed height at correct level; applying anti-embolism stockings from foot of bed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Gut Microbiota, PGx and INSTIs Response
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Dolutegravir|DRUG: Bictegravir|DRUG: Dolutegravir|DRUG: Dolutegravir|DRUG: Bictegravir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Time-restricted Hypocaloric Diet in Patients With NAFLD
Status: RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: OTHER: Early Time-Restricted Feeding Plus Hypocaloric Mediterranean Diet|OTHER: Late Time-Restricted Feeding Plus Hypocaloric Mediterranean Diet|OTHER: Hypocaloric Mediterranean Diet Without Time Restriction In Feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect Of Virtual Reality On Strength and Coordination in Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy (CP)
Interventions: DEVICE: Wii-based interactive training program|OTHER: Traditional physical therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Low-Dose Coronary Computed Tomographic Angiography for Early Triage of Acute Chest Pain
Status: COMPLETED
Conditions: Chest Pain
Interventions: OTHER: Low-dose Cardiac CT protocol|OTHER: Conventional cardiac CT protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: [KSR-001-P02] Phase 2b/3 Study, Evaluate the Efficacy and Safety of KSR-001 in Patients With Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: KSR-001-04|DRUG: KSR-001-02|DRUG: KSR-001-03
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The ASPIRE Trial - Aiming for Safe Pregnancies by Reducing Malaria and Infections of the Reproductive Tract
Status: COMPLETED
Conditions: Pregnancy Malaria|Bacterial Vaginoses|Trichomonas Vaginitis
Interventions: DRUG: IPTp-sulphadoxine-pyrimethamine plus metronidazole|DRUG: IPTp-dihydroartemisinin-piperaquine plus metronidazole|DRUG: IPTp-sulphadoxine-pyrimethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Addition of Metformin In Obese Non- Diabetic Patients With Heart Failure With Preserved Ejection Fraction
Status: RECRUITING
Conditions: Diastolic Dysfunction|Obesity
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive vs. Emotional Psychopharmacological Manipulations of Fear vs. Anxiety
Status: COMPLETED
Conditions: Anxiety Disorder
Interventions: DRUG: Propranolol|DRUG: Methylphenidate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Adaptive Design Study for Safety and Efficacy of Treatment Regimens With SM-020 in Subjects With Seborrheic Keratosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Seborrheic Keratosis
Interventions: DRUG: SM-020
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Profile of Inhaled TV48108 in Healthy Volunteers and COPD Patients
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: TV48108|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Group Therapy Versus Individual Therapy for Tourette Syndrome and Chronic Tic Disorder
Status: COMPLETED
Conditions: Chronic Tic Disorder
Interventions: BEHAVIORAL: tics training including habit reversal training and exposure response prevention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rosuvastatin Versus Atorvastatin in the Treatment of Hypercholesterolaemia in African American Subjects(ARIES)
Status: COMPLETED
Conditions: Hypercholesterolemia|Dyslipidaemia
Interventions: DRUG: Rosuvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy.
Status: RECRUITING
Conditions: Cerebral Amyloid Angiopathy
Interventions: OTHER: neurological, neuropsychological and MRI evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Quercetin on Blood Sugar and Blood Vessel Function in Type 2 Diabetes.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DIETARY_SUPPLEMENT: Quercetin|DRUG: Acarbose|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase Ib/II Study of MCS110 in Combination With PDR001 in Patients With Advanced Malignancies
Status: COMPLETED
Conditions: Triple Negative Breast Cancer|Pancreatic Carcinoma|Melanoma|Endometrial Carcinoma
Interventions: DRUG: MCS110|DRUG: PDR001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ipamorelin Compared to Placebo for the Recovery of Gastrointestinal Function
Status: COMPLETED
Conditions: Gastrointestinal Dysmotility
Interventions: DRUG: Saline Solution for Injection|DRUG: Ipamorelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Observation Plus Imagination of Gait on Stride Variability in Young and Older Adults
Status: COMPLETED
Conditions: Gait Variability; Elders; Fall; Re-education
Interventions: OTHER: Observation & imagination|OTHER: Reading
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety of Recombinant Hybrid GMZ 2 [GLURP + MSP 3] Blood Stage Malaria Vaccine
Status: UNKNOWN
Conditions: Malaria
Interventions: BIOLOGICAL: GMZ2 (malaria vaccine)|BIOLOGICAL: GMZ2 malaria vaccine|BIOLOGICAL: Verorab vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Efficacy and Safety of CS-3150 in Japanese Hypertensive Subjects
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: CS-3150|DRUG: placebo|DRUG: eplerenone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Polatuzumab Vedotin, Venetoclax, and Rituximab and Hyaluronidase Human for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent B-Cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3a Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Refractory B-Cell Non-Hodgkin Lymphoma|Refractory Grade 1 Follicular Lymphoma|Refractory Grade 2 Follicular Lymphoma|Refractory Grade 3a Follicular Lymphoma|Refractory Mantle Cell Lymphoma|Refractory Marginal Zone Lymphoma|Refractory Small Lymphocytic Lymphoma
Interventions: DRUG: Polatuzumab Vedotin|BIOLOGICAL: Rituximab|BIOLOGICAL: Rituximab and Hyaluronidase Human|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Elderberry for Immune Support
Status: RECRUITING
Conditions: Upper Respiratory Tract Infection|COVID-19|Flu|Flu Like Illness|Cold
Interventions: DIETARY_SUPPLEMENT: Elderberry|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity and Safety of Different Vaccination Schedules of Tetravalent Dengue Vaccine in Healthy Subjects 9 to 50 Years of Age
Status: COMPLETED
Conditions: Dengue Fever|Dengue Hemorrhagic Fever
Interventions: BIOLOGICAL: CYD Dengue Vaccine|BIOLOGICAL: Placebo (Sodium chloride 0.9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Nicotine Patch / Lorcaserin for Smoking Cessation
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: DRUG: lorcaserin|DRUG: nicotine patch|DRUG: placebo lorcaserin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Motivate: A Web-based Intervention
Status: COMPLETED
Conditions: Eating Disorders
Interventions: BEHAVIORAL: Motivate: a web-based intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hymovis® Intra-articular Injections vs Corticosteroids Intra-articular Injections in Patients Affected by Glenohumeral Osteoarthritis:
Status: COMPLETED
Conditions: Glenohumeral Osteoarthritis
Interventions: DEVICE: Hyaluronic Acid 24 MG in 3 mL Prefilled Syringe|DRUG: Corticosteroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega-3 PUFA for Treatment of Patients With Idiopathic Oligoasthenoteratospermia
Status: UNKNOWN
Conditions: Male Infertility Due to Hypospermatogenesis
Interventions: DRUG: Omega 3 fatty acid|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaginal Wound Infiltration Analgesia for Postoperative Pain After Laparoscopic Hysterectomy: a Randomized Trial
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: PROCEDURE: Vaginal wound local analgesia after laparoscopic hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Insulin: A Novel Treatment for Gulf War Multisymptom Illness
Status: UNKNOWN
Conditions: Chronic Multisymptom Illness in Gulf War Veterans
Interventions: DRUG: Intranasal Insulin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Multiple Oral Doses of PF-07081532 in Adult Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: PF-07081532|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Treatment Effects of PowerScope2 and Forsus Using CBCT
Status: COMPLETED
Conditions: Class II Division 1 Malocclusion
Interventions: DEVICE: Class II correction using PowerScope2|DEVICE: Class II correction using Forsus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Myosteatosis in Oeso-gastric Cancer: Clinical Impacts
Status: RECRUITING
Conditions: Esophageal Cancer|Gastric Cancer|Myopenia|Adipose Tissue Tumor
Interventions: DIAGNOSTIC_TEST: Myosteatosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influence of Manual Diaphragm Release on Pulmonary Functions in Women With COVID-19
Status: COMPLETED
Conditions: COVID-19 Pneumonia
Interventions: OTHER: manual therapy|OTHER: breathing exercise and prone position alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Pain and Opioid Use With CBD
Status: RECRUITING
Conditions: Opioid Use Disorder
Interventions: DRUG: Cannabidiol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Neoadjuvant Chemotherapy of Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Neoadjuvant chemotherapy|DRUG: Chemotherapy|DRUG: Neoadjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Clinical Trial of Recombinant SARS-CoV-2 Spike Protein Vaccine (CHO Cell) for the Prevention of COVID-19
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: 202-CoV low adjuvant dose|BIOLOGICAL: 202-CoV low antigen dose|BIOLOGICAL: 202-CoV standard dose|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Computer-based Social Skills Training for Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DEVICE: Lookware TM|DEVICE: Lookware TM Control Module
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Manipulation and Dry Needling Versus Conventional Physical Therapy in Patients With Sacroiliac Dysfunction
Status: COMPLETED
Conditions: Sacroiliac Joint Dysfunction
Interventions: OTHER: HVLA Thrust Manipulation and DN|OTHER: Conventional Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-antigen CMV-Modified Vaccinia Ankara Vaccine in Reducing CMV Related Complications in Patients With Blood Cancer Undergoing Donor Stem Cell Transplant
Status: WITHDRAWN
Conditions: Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Acute Lymphoblastic Leukemia in Remission|Acute Myeloid Leukemia in Remission|Bone Marrow Transplantation Recipient|Chronic Lymphocytic Leukemia|Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Hematopoietic Cell Transplantation Recipient|Hodgkin Lymphoma|Myelodysplastic Syndrome|Myelofibrosis|Myeloproliferative Neoplasm|Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: Multi-antigen CMV-Modified Vaccinia Ankara Vaccine|OTHER: Laboratory Biomarker Analysis|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The In4M Study: Integrating 4 Methods to Assess Physical Function in Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Physical Function|Cancer, Breast|Lymphoma|Patient Empowerment|Patient Education|Quality of Life
Interventions: OTHER: PRO Instruments assessment questionnaire|OTHER: Baseline Survey Clinician- reported (ClinRO) ECOG|DEVICE: Fitbit|OTHER: Hugo Health ("Hugo")|OTHER: 6 Minute Walk Test (6MWT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of a New Formulation Useful for the Osteoarthrosis Treatment
Status: UNKNOWN
Conditions: Osteoarthritis
Interventions: DRUG: kondrium|DRUG: kondrium f|DRUG: methyl prednisolone (corticosteroid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Aromatherapy on Venopuncture Pain and Anxiety
Status: COMPLETED
Conditions: Pain
Interventions: PROCEDURE: peripheral venous cannulation|PROCEDURE: Aromatherapy with lavender essential oil|PROCEDURE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Selective Dorsal Rhizotomy on Non-ambulant Children With Bilateral Spastic Cerebral Palsy
Status: COMPLETED
Conditions: Bilateral Cerebral Palsy
Interventions: OTHER: sequenced trunk co-activation exercises|OTHER: Standard Orthotic Management|OTHER: selective dorsal rhizotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing Medication Dispensing Errors in Pharmacy Practice With Interpretable Machine Intelligence
Status: RECRUITING
Conditions: Machine Intelligence in the Pharmacy
Interventions: BEHAVIORAL: No MI Help|BEHAVIORAL: Scenario #1|BEHAVIORAL: Scenario #2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cardio-vascular Protective Effects of Wolfberry in Middle-aged and Older Adults
Status: COMPLETED
Conditions: Cardiovascular Diseases|Aging
Interventions: OTHER: Wolfberry|OTHER: Healthy diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of LY3502970 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3502970|DRUG: Placebo|DRUG: Atorvastatin|DRUG: Simvastatin|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Controlled Study of MK-0431/ONO-5435 in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bearberry in the Treatment of Cystitis
Status: NOT_YET_RECRUITING
Conditions: Cystitis
Interventions: DRUG: Fosfomycin|DRUG: Bearberry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Interaction-Based Early Education Program Applied to Grandparents on the Grandchildren's Health
Status: ENROLLING_BY_INVITATION
Conditions: Grandparents|Growth Disorders|Development, Child|Feeding Behavior|Parent-Child Relations
Interventions: BEHAVIORAL: Interaction-Based Early Education Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Short-Stay Intensive Care for Coronary Artery Bypass Patients
Status: COMPLETED
Conditions: Coronary Artery Bypass
Interventions: PROCEDURE: Control group (usual care)|PROCEDURE: Short-Stay Intensive Care treatment (SSIC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Use of IV Scopolamine to Augment the Efficacy of Electroconvulsive Therapy (ECT)
Status: TERMINATED
Conditions: Depression
Interventions: DRUG: Scopolamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Using Vaccination With Heat Shock Protein 70 (HSP70) for the Treatment of CML in Chronic Phase
Status: COMPLETED
Conditions: Leukemia,Myeloid, Chronic|Leukemia,Myeloid,Philadelphia-Positive
Interventions: BIOLOGICAL: Heat Shock Protein 70 HSP70
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Basket Study to Assess Efficacy, Safety and PK of Iptacopan (LNP023) in Autoimmune Benign Hematological Disorders
Status: TERMINATED
Conditions: Immune Thrombocytopenia (ITP)|Cold Agglutinin Disease (CAD)
Interventions: DRUG: Iptacopan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of Potential Anti-Inflammatory Effects of Glucose Control During Acute Myocardial Infarction.
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Intensive insulin therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ADHD/Me Bibliotherapy Study
Status: TERMINATED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: OTHER: ADH-Me Book and ADHD Informational Brochure|OTHER: ADHD Informational Brochure Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: High-fidelity Simulation in Health Care Education
Status: UNKNOWN
Conditions: Healthy
Interventions: DEVICE: High-fidelity high-fidelity mannequin simulator (SimMan, Laerdal, Stavanger, Norway).
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase II Study of Different Doses of Radiotherapy Combined With Sintilimab in the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: chemoradiotherapy （CRT）+sintilimab 1|DRUG: CRT+sintilimab 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Frontoparietal Synchronization to Modulate Drug Craving in Opioid Use Disorder
Status: COMPLETED
Conditions: Opioid-use Disorder
Interventions: DEVICE: Transcranial Alternating Current Stimulation (tACS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy Study Measuring the Impact of Pregabalin on Peripheral Neuropathic Pain.
Status: COMPLETED
Conditions: Neuropathic Pain
Interventions: DRUG: Pregabalin (Lyrica)|DRUG: Pregabalin (Lyrica)|DRUG: Pregabalin (Lyrica)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Viapaed Study In Children And Adolescents With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Salmeterol/fluticasone|DRUG: Fluticasone propionate|DRUG: Salbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Safety, and Efficacy of Intravenous Dosing of Buprenorphine in Pediatric Patients Who Require Opioid Analgesia for Acute Moderate to Severe Pain
Status: WITHDRAWN
Conditions: Other Acute Postoperative Pain|Prolonged Endotracheal Intubation
Interventions: DRUG: Buprenorphine IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Treatment With Lutetium[177Lu] Oxodotreotide Injection to Octreotide LAR in Patients With GEP-NETs
Status: ACTIVE_NOT_RECRUITING
Conditions: Neuroendocrine Tumors
Interventions: DRUG: Lutetium[177Lu] Oxodotreotide Injection|DRUG: Octreotide LAR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Indocyanine Green Test for Evaluation of Perfusion of Staple Line of the Stomach During Laparoscopic Sleeve Gastrectomy
Status: COMPLETED
Conditions: Obesity, Morbid|Diabete Type 2|Cardiac Disease|Vascular Diseases
Interventions: DRUG: Indocyanine green solution
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nivolumab and Ipilimumab +/- UV1 Vaccination as Second Line Treatment in Patients With Malignant Mesothelioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer|Cancer, Lung|Cancer of Lung|Mesothelioma|Mesothelioma; Lung|Mesothelioma; Pleura|Mesotheliomas Pleural
Interventions: BIOLOGICAL: UV1 vaccine + leukine|BIOLOGICAL: ipilimumab|BIOLOGICAL: nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Truview Laryngoscopy and Macintosh Larygonscopy on Intubation Difficulty Score, Intubation Duration and Intubation Quality in Pediatric Patients Between 2-12 Years
Status: COMPLETED
Conditions: All the Pediatric Patients Needed Intubation for Surgery
Interventions: PROCEDURE: Macintosh laryngoscope|PROCEDURE: Truview EVO2 laryngoscope
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Concurrent Intrathecal-pemetrexed and Involved-field Radiotherapy for Leptomeningeal Metastasis From Solid Tumors
Status: COMPLETED
Conditions: Leptomeningeal Metastasis
Interventions: DRUG: Pemetrexed|DRUG: Dexamethasone|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics Study of Human Monoclonal Antibody BRII-198
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: BRII-198|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of MDX-1342 in Patients With Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: MDX-1342
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analysis of Prognosis and Risk Factors of LAL Reconstruction Procedure for Patients With AF of the LAL: a Prospective Cohort Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Avulsion Fracture of Lateral Ankle Ligament
Interventions: PROCEDURE: lateral ankle ligament repair or reconstruction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Single Agent Lenalidomide in Older Adults With Newly Diagnosed Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide|DRUG: Prednisone|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of 18F-AV-133 and 18F-AV-45 Positron Emission Tomography (PET)
Status: COMPLETED
Conditions: Dementia With Lewy Bodies|Alzheimer's Disease|Parkinson's Disease
Interventions: DRUG: 18F-AV-133|DRUG: 18F-AV-45
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Randomized Controlled Trial of Antibiotics in the Management of Children With Community-Acquired Abscess
Status: TERMINATED
Conditions: Abscess Soft Tissue|Methicillin-resistant Staphylococcus Aureus (MRSA) Infection|Skin Abscess
Interventions: DRUG: Oral Clindamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relation Among Shear Stress Distribution, Stent Design, and Subsequent Vessel Healing After Drug-eluting Stent Implantation (SHEAR DES)
Status: UNKNOWN
Conditions: Coronary Heart Disease
Interventions: DEVICE: Promus element, Xience prime, and Nobori
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Goat Lung Surfactant for the Treatment of Respiratory Distress Syndrome in Preterm Neonates
Status: UNKNOWN
Conditions: Respiratory Distress Syndrome
Interventions: DRUG: Cadisurf|DRUG: Survanta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Early RA: Minocycline in Combination With Methotrexate vs Methotrexate Alone
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Combination of Minocycline and MTX or MTX alone|DRUG: methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: the Effect of Vestibular Rehabilitation in Autistic Children
Status: COMPLETED
Conditions: Autistic Spectrum Disorder|Vestibular Disorder|Sensory Integration Disorder
Interventions: OTHER: The education of sensory integration with vestibular education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen - a New Treatment Modality in Patients With Radiation Damaged Salivary Gland Tissue
Status: UNKNOWN
Conditions: Late Effect of Radiation
Interventions: PROCEDURE: Hyperbaric oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamic Effects of PQR309 in Glioblastoma Patients
Status: TERMINATED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: PQR309
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil
Status: WITHDRAWN
Conditions: Sickle Cell Anemia
Interventions: DRUG: Viagra (Sildenafil)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate NRCT-101SR in Pediatric Subjects With ADHD
Status: RECRUITING
Conditions: Attention-Deficit/Hyperactivity Disorder (ADHD)
Interventions: DRUG: NRCT-101SR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pregabalin Given Preoperatively on the Tourniquet Induced Ischemia-reperfusion
Status: COMPLETED
Conditions: Ischemia Reperfusion Injury
Interventions: DRUG: Pragabalin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Peribulbar Block for Prevention of Oculocardiac Reflex
Status: UNKNOWN
Conditions: Strabismus
Interventions: DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A First In Human Study In Healthy People To Evaluate Safety, Toleration, Pharmacokinetics and Pharmacodynamics of Single Oral Doses Of PF-06372865
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06372865 or Placebo|DRUG: PF-06372865 or Placebo|DRUG: PF-06372865 or Placebo|DRUG: PF-06372865 or Placebo or Lorazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: UCMSCs as Front-line Approach of Treatment for Patients With aGVHD
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute-graft-versus-host Disease
Interventions: BIOLOGICAL: Umbilical cord derived mesenchymal stem cell|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Antiviral Study of ACH126, 433 (b-L-Fd4C) in Adults With Lamivudine-resistant Chronic Hepatitis B
Status: TERMINATED
Conditions: Chronic Hepatitis B
Interventions: DRUG: ACH126, 433
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Black Tea Mouthwash on Plaque Formation
Status: COMPLETED
Conditions: Gingivitis
Interventions: DIETARY_SUPPLEMENT: Black Tea|DIETARY_SUPPLEMENT: Green Tea|DRUG: 0.12% Chlorhexidine Mouthwash.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia
Status: RECRUITING
Conditions: Hypoxic Ischemic Encephalopathy
Interventions: DRUG: Melatonin|OTHER: Magnetic Resonance Imaging|OTHER: Pharmacokinetics|BEHAVIORAL: Neurological Outcome Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: WAL801CL (Epinastine Hydrochloride) Dry Syrup in Paediatric Perennial Allergic Rhinitis
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial
Interventions: DRUG: WAL801CL dry syrup|DRUG: Ketotifen fumarate dry syrup|DRUG: Ketotifen fumarate dry syrup placebo|DRUG: WAL 801 CL dry syrup placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Airway Secretion Clearance in Cystic Fibrosis
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DEVICE: High frequency chest wall oscillation|DEVICE: Oscillatory Positive Expiratory Pressure|OTHER: PD&P: Postural drainage and percussion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tracers for Endometrial Cancer Sentinel Node Labeling
Status: UNKNOWN
Conditions: Endometrial Cancer|Sentinel Lymph Node
Interventions: PROCEDURE: SLN side-specific detection rate using radioactive tracer with/without blue dye and ICG tracer.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: NKX101, Intravenous Allogeneic CAR NK Cells, in Adults With AML or MDS
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed/Refractory AML|AML, Adult|MDS|Refractory Myelodysplastic Syndromes
Interventions: BIOLOGICAL: NKX101 - CAR NK cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupressure and Stress Resilience
Status: COMPLETED
Conditions: Post-traumatic Stress Disorder (PTSD)|Mild Traumatic Brain Injury (mTBI)
Interventions: OTHER: Active Acupressure Treatment|OTHER: Placebo Acupressure Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT