pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparison of Quadriceps Strengthening and Kinesiotaping on Gait in Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: group A concentric muscle training|OTHER: Group B fascilitatory kinesiotaping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does IVPCA Increase Opioid Consumption and Side Effects in Fast Track Orthopedic Procedures?
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: Morphine as IVPCA|DRUG: Hydromorphone as IVPCA|DRUG: Morphine|DRUG: Hydromorphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Influence of the Crown-implant Ratio on the Crestal Bone Level and Implant Secondary Stability
Status: COMPLETED
Conditions: Partial Edentulism|Tooth Loss
Interventions: OTHER: Short implants Treatment|OTHER: Regular implants Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Institutional Audit of the Short Term Complications and Long Term Outcomes of Patients Undergoing Laparoscopic Sacrocolpopexy for Vault/Cervical Prolapse.
Status: ENROLLING_BY_INVITATION
Conditions: Vault Prolapse, Vaginal
Interventions: PROCEDURE: Sacrocolpopexy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Investigate Drug-drug Interaction and Relative Bioavailability Between the FDC AzelastineHCL/Beclomethasone Dipropionate Nasal Spray, & Beclomethasone Dipropionate Nasal Spray in the Test Vehicle, and RinoClenil® Nasal Spray
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: 140/100 μg Azelastine hydrochloride/Beclomethasone Dipropionate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bortezomib (Velcade) + Pemetrexed (Alimta) in Advanced NSCLC
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3D Printed Rigid Bolus Versus Silicone Bolus for Treatment of Tumors Involving the Skin: A Comparative Study
Status: WITHDRAWN
Conditions: Skin Neoplasm Malignant|Skin Cancer
Interventions: OTHER: Ingeo Biopolymer (PLA)|OTHER: Ecoflex 030
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: ToleroMune Grass Exposure Unit Study
Status: COMPLETED
Conditions: Grass Allergy|Rhinoconjunctivitis
Interventions: BIOLOGICAL: ToleroMune Grass|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Effects and Safety of Dulaglutide With Glimepiride in Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Dulaglutide|DRUG: Glimepiride|DRUG: Placebo as Capsules|DRUG: Placebo as SC Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Randomized Pharmacokinetics and Safety Study of Extended Duration Dapivirine Vaginal Rings
Status: COMPLETED
Conditions: HIV-1-infection
Interventions: COMBINATION_PRODUCT: Dapivirine Vaginal Ring, 25 mg|COMBINATION_PRODUCT: Dapivirine Vaginal Ring, 100 mg|COMBINATION_PRODUCT: Dapivirine Vaginal Ring, 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Phase 2 Study of 9-ING-41 With Chemotherapy in Sarcoma
Status: WITHDRAWN
Conditions: Soft Tissue Sarcoma|Undifferentiated Pleomorphic Sarcoma|Myxofibrosarcoma|Leiomyosarcoma|Liposarcoma|Angiosarcoma|Synovial Sarcoma|Rhabdomyosarcoma|Spindle Cell Sarcoma|High Grade Sarcoma|Bone Sarcoma|Osteosarcoma|Ewing Sarcoma of Bone
Interventions: DRUG: Gemcitabine|DRUG: 9-ING-41|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interactions Between HIV and Malaria in African Children
Status: COMPLETED
Conditions: Malaria|HIV Infections
Interventions: DRUG: Dihydroartemisinin-piperaquine|DRUG: Artemether-lumefantrine|DRUG: Trimethoprim-sulfamethoxazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Examine the Safety and Tolerability of Single Ascending Doses of REGN2477
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: REGN2477|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Clinical Efficacy and Safety of Amlodipine 5mg/ Bisoprolol Fumarate 5mg /Perindopril Arginine 5mg Fixed-dose Combination in Capsule and Free Monotherapy at the Same Dose in Patients With Uncontrolled Essential Hypertension.
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: COMBINATION_PRODUCT: Amlodipine 5mg + bisoprolol fumarate 5mg + perindopril arginine 5mg|DRUG: Norvasc 5mg tablet|DRUG: Concor 5mg tablet|DRUG: Coversyl 5mg tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Electrical Micro-current Retinal Stimulation for Treatment of Dry Age-related Macular Degeneration
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DEVICE: Tesmac|DEVICE: Sham Tesmac device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Delivery of Vitamin D3 as Vitamin D Supplementation
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DRUG: Application of topical vitamin d3 (Top-D)|OTHER: Application of Aloe vera gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant CCRT With Gemcitabine/Durvalumab (MEDI4736) Followed by Adjuvant Gemcitabine/Durvalumab(MEDI4736) in Resectable or Borderline Resectable Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Manuka Honey as an Adjunct to Non-surgical Periodontal Therapy: Clinical Study
Status: COMPLETED
Conditions: Periodontal Diseases|Periodontal Pocket|Periodontal Bone Loss|Periodontal Attachment Loss
Interventions: BIOLOGICAL: Manuka honey
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation of Two Transdiagnostic Interventions Based on Emotional Regulation (DBT and UP) for Alcohol Addiction
Status: RECRUITING
Conditions: Implementation Science
Interventions: BEHAVIORAL: Dialectical Behavior Therapy for Substance Use Disorder (DBT-SUD)|BEHAVIORAL: Unified Protocol (UP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Dose Escalation Study of a PD1-LAG3 Bispecific Antibody in Patients With Advanced and/or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Solid Tumors|Metastatic Melanoma|Non-small Cell Lung Cancer|Esophageal Squamous Cell Carcinoma
Interventions: DRUG: RO7247669
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gene Mutation in Samples From Young Patients With Pleuropulmonary Blastoma Syndrome at Risk for Developing Cancer
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Hereditary Wilms Tumor|Kidney Cancer|Liver Cancer|Neuroblastoma|Pleuropulmonary Blastoma|Sarcoma
Interventions: GENETIC: DNA analysis|GENETIC: cytogenetic analysis|GENETIC: gene expression analysis|GENETIC: gene rearrangement analysis|GENETIC: mutation analysis|GENETIC: polymerase chain reaction|GENETIC: polymorphism analysis|OTHER: laboratory biomarker analysis|OTHER: medical chart review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Imatinib Mesylate in Treating Patients With Recurrent or Persistent Uterine Cancer
Status: COMPLETED
Conditions: Recurrent Uterine Sarcoma|Uterine Carcinosarcoma
Interventions: DRUG: imatinib mesylate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heart Biomarker Evaluation in Apnea Treatment
Status: COMPLETED
Conditions: Cardiovascular Disease|Obstructive Sleep Apnea|Coronary Artery Disease
Interventions: OTHER: Healthy Lifestyles and Sleep Education plus PAP|OTHER: Healthy Lifestyles and Sleep Education plus Supplemental Oxygen|OTHER: Healthy Lifestyles and Sleep Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Galvanic Vestibular Stimulation and Motor Training in Traumatic Brain Injury Survivors
Status: TERMINATED
Conditions: TBI|Attention Deficits|Motor Impairments
Interventions: DEVICE: GVS|DEVICE: Sham GVS|DEVICE: Armeo Spring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial of Written Exposure for Metastatic Cancer Patients (EASE)
Status: COMPLETED
Conditions: Metastatic Cancer|Solid Tumor Cancer|Lymphoproliferative Disorders|Anxiety|Post-traumatic Stress Symptoms|Fear of Cancer Progression
Interventions: BEHAVIORAL: Written Exposure Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neoadjuvant Nab-paclitaxel in Triple-negative or HER2-positive Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Triple Negative Breast Cancer|HER2-positive Breast Cancer
Interventions: DRUG: Nab-paclitaxel|DRUG: Carboplatin|DRUG: Herceptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Immune Response to Two Doses of a Dengue Virus Vaccine Administered 12 Months Apart
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: TV003 Vaccine|BIOLOGICAL: Placebo Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Masks Against Surface-Scanning for Radiation Therapy Immobilisation in Head and Neck Cancer (MASSC)
Status: UNKNOWN
Conditions: Head and Neck Neoplasm
Interventions: RADIATION: Radiotherapy with Closed Mask|RADIATION: Radiotherapy with Open Mask and Surface Scanning|RADIATION: Radiotherapy with No Mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Conventional Palpation Versus Ultrasound Assisted Spinal Anesthesia in Obstetrics
Status: RECRUITING
Conditions: Obese|Cesarean Section|Anesthesia Spinal
Interventions: PROCEDURE: Preprocedural spinal ultrasound|PROCEDURE: fictional preprocedure spinal ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Oxycodone-naloxone Prolonged Release Tablets in Relieving Opioid-related Constipation
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Oxycodone naloxone prolonged release tablets (OXN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Renin Profiling in Selection of Initial Antihypertensive Drug
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: olmesartan, hydrochlorothiazide, amlodipine|DRUG: hydrochlorothiazide (HCTZ) or olmesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of How the Dose of Dialysis is Affected by Dialysate Flow Rate
Status: COMPLETED
Conditions: Chronic Kidney Disease|Chronic Renal Disease
Interventions: OTHER: Dialysis Flow Rate Start 600mL/min|OTHER: Dialysis Flow Rate Start 800mL/min
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Therapy in HR-positive/HER2-negative Metastatic Breast Cancer(ENIGMA)-BCTOP-L-M02
Status: RECRUITING
Conditions: Breast Cancer|Metastatic Cancer
Interventions: DRUG: SHR-1316|DRUG: SHR6390|DRUG: Nab paclitaxel|DRUG: SERD|DRUG: AI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison Between EBUS-GS and CT-guided Lung Biopsy in Diagnosis of Peripheral Pulmonary Lesions.
Status: UNKNOWN
Conditions: Lung Neoplasms
Interventions: PROCEDURE: EBUS-GS|PROCEDURE: CT-TTNB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Glucagon-like Peptide-1 and Coronary Microvascular Dysfunction in Women With Angina Pectoris and no Coronary Stenosis
Status: COMPLETED
Conditions: Microvascular Angina
Interventions: DRUG: Liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Magnitude and Duration of Response of MK0954 Compared to Placebo in Patients With Hypertension (0954-021)(COMPLETED)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: losartan potassium|DRUG: Comparator: placebo|DRUG: hydrochlorothiazide (HCTZ)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study of Oral Deflazacort in Children and Adolescent Subjects With Duchenne Muscular Dystrophy
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: Deflazacort
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Antimicrobial Coated Sutures in Paediatric Surgery
Status: COMPLETED
Conditions: Wound Infections
Interventions: OTHER: Triclosane|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Understanding the Risk of Blood Clots and Bleeding in Patients With Hematological Malignancies, HAT Study
Status: RECRUITING
Conditions: Acute Leukemia|Deep Vein Thrombosis|Hematopoietic and Lymphoid Cell Neoplasm|Hodgkin Lymphoma|Myeloproliferative Neoplasm|Non-Hodgkin Lymphoma|Plasma Cell Myeloma|Thrombocytopenia
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Electronic Health Record Review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Personalized Medicine Interface Tool (PerMIT): Warfarin: A Trial Comparing Usual Care Warfarin Initiation to PerMIT Pharmacogenetic Guided Warfarin Therapy
Status: COMPLETED
Conditions: Blood Clotting
Interventions: GENETIC: warfarin pharmacogenetic dosing|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, First-in-human Study of VX-668
Status: COMPLETED
Conditions: Alpha-1 Antitrypsin Deficiency
Interventions: DRUG: VX-668|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immediate and Residual Effects of Functional Chewing Gum on Concentration
Status: COMPLETED
Conditions: Cognitive Change
Interventions: DIETARY_SUPPLEMENT: Functional Gum|DIETARY_SUPPLEMENT: Basic Chewing Gum|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Enhancing Ultrasound & Photoacoustic for Recognition of Intestinal Abnormalities
Status: SUSPENDED
Conditions: Inflammatory Bowel Diseases|Ulcerative Colitis|Crohn Disease
Interventions: DIAGNOSTIC_TEST: Multispectral Optoacoustic Tomography (MSOT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study on the Correlation Between Intestinal Microecology and Allergic Diseases in Children
Status: UNKNOWN
Conditions: Rhinitis, Allergic|Asthma|Dermatitis, Atopic|Urticaria
Interventions: DRUG: probiotics|DRUG: conventional medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing the Efficacy of Peripherally Inserted Central Catheter (PICC) Placement With the Addition of Cyanoacrylate Glue Versus PICC Placement Alone in Patients With Cancer.
Status: RECRUITING
Conditions: Cancer
Interventions: PROCEDURE: Cyanoacrylate glue application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Glyceryl Tri-(4-phenylbutyrate) (GT4P)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HPN-100|DRUG: Ammonul|DRUG: Buphenyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation in RNA-seq Profiles of Single-core Prostate Samples, Among Veterans
Status: COMPLETED
Conditions: Prostate Cancer|Vitamin D Deficiency|Stress Reaction
Interventions: DRUG: cholecalciferol|PROCEDURE: Standard of Care Prostate Biopsy - collection of 13th core for RNA-seq|PROCEDURE: Standard of Care Prostate Biopsies at baseline and after one year vitamin D3 supplementation|DIAGNOSTIC_TEST: Allostatic Load Measurements at baseline and after one year vitamin D3 supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Tenalisib (RP6530), in Patients With Locally Advanced or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Locally Advanced Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: Tenalisib 800mg|DRUG: Tenalisib 1200mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of the Glutamatergic System in the Extinction of Conditioned Reinforcement Processes
Status: UNKNOWN
Conditions: Alcohol Drinking
Interventions: DRUG: D-cycloserine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PRAGUE-25 Trial. Catheter Ablation vs. AADs and Risk Factor Modification.
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Catheter ablation|COMBINATION_PRODUCT: Risk Factor Modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Biomarkers After Single Doses of Anticoagulants in Healthy Young Male and Healthy Elderly Participants (MK-0000-216 AM1)
Status: COMPLETED
Conditions: Thrombosis
Interventions: DRUG: dabigatran etexilate|DRUG: rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Importance of Glucagon-Like Peptide-2 (GLP-2)in Mesenteric Bloodflow in Humans
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: GLP-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy of BST-CarGel in Treating Chondral Lesions of the Hip
Status: WITHDRAWN
Conditions: Disorder of Hip Region
Interventions: DEVICE: BST-CarGel|PROCEDURE: Microfracture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of ACP-501 on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Subjects With Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease|Atherosclerosis
Interventions: DRUG: ACP-501
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy & Safety of SmofKabiven Emulsion for Infusion vs Hospital Compounded "All in One" for Parenteral Nutrition
Status: COMPLETED
Conditions: Parenteral Nutrition|Surgery
Interventions: DRUG: SmofKabiven emulsion for infusion|DRUG: Hospital compounded "All in one" emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Perinatal Hypothermia, Risk Factors and Long-Term Consequences in Guinea-Bissau, Westafrica
Status: UNKNOWN
Conditions: Hypothermia|Morbidity|Mortality
Interventions: DEVICE: thermospot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Iron Supplementation and Side Effects
Status: COMPLETED
Conditions: Iron Deficiency Anemia|Iron Overload
Interventions: DIETARY_SUPPLEMENT: Ferrous sulfate|DIETARY_SUPPLEMENT: Aspiron|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ultra-hypofractioNated Adjuvant Radiotherapy ± sImultaneous Integrated Boost for Low-risk Breast Cancer Patients
Status: RECRUITING
Conditions: Breast Cancer|Radiotherapy Side Effect
Interventions: RADIATION: Ultra-fractionated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Aquatic Physiotherapy in Children With Microcephaly by Zika Virus Congenital Syndrome
Status: COMPLETED
Conditions: Zika Virus Infection|Microcephaly
Interventions: BEHAVIORAL: aquatic physicotherapy|BEHAVIORAL: immersion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impacts of Aquatic vs Land Walking on Vascular Health and Exercise Tolerance in Patients With Peripheral Artery Disease
Status: COMPLETED
Conditions: Peripheral Artery Disease|Vascular Function|Exercise Tolerance|Peripheral Arterial Disease
Interventions: OTHER: Aquatic walking exercise program group 1|OTHER: Aquatic walking exercise program group 2|OTHER: Land-based walking exercise group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Body Therapy for War Veterans With Post Traumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic|Trauma and Stressor Related Disorders|Behavioral Symptoms|Depression|Quality of Life
Interventions: BEHAVIORAL: Body therapy|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Hyperbaric Oxygen Therapy (HBOT) in New-onset Type-1 Diabetes Mellitus
Status: RECRUITING
Conditions: T1DM
Interventions: DEVICE: Hyperbaric oxygen chamber (HBOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ebselen as an add-on Treatment in Hypo/Mania
Status: COMPLETED
Conditions: Bipolar Disorder|Bipolar Disorder, Manic
Interventions: DRUG: Ebselen|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Distal Limbs Fractures With Cone-Beam CT Newtom 5G
Status: COMPLETED
Conditions: Distal Limbs Bones Fractures
Interventions: DEVICE: The patients will have a conventional scanner, a reference examination, and a cone-beam scanner Newtom 5G just after the conventional scanner
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Based on the Ultrasound Evaluating the Effect of Xiaozhong Fang Particles for Knee Osteoarthritic With Synovial Fluid
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DRUG: Xiao zhong fang granules|RADIATION: Short wave infrared radiation|DRUG: Placebo Xiao zhong fang granules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 in Allogeneic Hematopoietic Stem Cell Transplant Recipients (V114-022/PNEU-STEM)
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: V114|BIOLOGICAL: Prevnar 13™|BIOLOGICAL: PNEUMOVAX™23
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Gait Pattern Comparison of Cruciate-retaining and Posterior-stabilized Arthroplasties
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: total knee arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Safety, Tolerability, Steady State Pharmacokinetic and Pharmacodynamic Profile of BIA 3-202
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: BIA 3-202|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of DigiCog and Konectom Tools to Support Digitalized Clinical Assessment in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DIAGNOSTIC_TEST: DigiCog (BCCAMS app)|DIAGNOSTIC_TEST: Konectom Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study of Biphasic Insulin Aspart 30 Alone or in Combination With Oral Hypoglycaemic Agents in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart 30
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Inhaled Oxytocin (IH) With Intramuscular (IM) Oxytocin in Pregnant Women and With Intravenous (IV) Oxytocin in Healthy Non-pregnant Women
Status: TERMINATED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: IH Oxytocin|DRUG: IM Oxytocin|DRUG: IV Oxytocin|DEVICE: ROTAHALER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest in Smokeless Tobacco Product as a Substitution for Cigarettes in Current Smokers
Status: TERMINATED
Conditions: Tobacco Use Disorder
Interventions: BEHAVIORAL: smoking cessation intervention|BEHAVIORAL: smoking cessation intervention|OTHER: questionnaire administration|OTHER: quality-of-life assessment|OTHER: laboratory biomarker analysis|OTHER: ecigarettes|OTHER: ecigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of OCTA-guided PDT in Acute CSC
Status: COMPLETED
Conditions: Central Serous Chorioretinopathy|Tomography, Optical Coherence
Interventions: PROCEDURE: OCTA-guided Photodynamic therapy|PROCEDURE: ICGA-guided Photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Peripheral Blood Specimens From Patients Suspected of Having SARS-CoV-2 Infections in Research Studies Intended to Support the Development of COVID-19 Detection Methods, Treatments, and/or Vaccines
Status: UNKNOWN
Conditions: SARS-CoV-2
Interventions: DIAGNOSTIC_TEST: nasal pharyngeal (NP) swab samples|DIAGNOSTIC_TEST: peripheral blood draw
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Presence of Aquarium in the Waiting Room of a Geriatric Dental Clinic
Status: UNKNOWN
Conditions: Stress|Anxiety|Mood
Interventions: OTHER: No intervention|OTHER: Partially-equipped aquarium in the waiting area|OTHER: Fully-equipped aquarium in the waiting area
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: The Effect of Aromatherapy Massage on Sleep Quality
Status: RECRUITING
Conditions: Diabetes Mellitus|Respiratory Failure|Pneumonia|Respiratory Disease|Stroke, Ischemic
Interventions: OTHER: Intervention 1 Group|OTHER: Intervention 2 Group|OTHER: Placebo Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Microprocessor Knees in Early Rehabilitation
Status: COMPLETED
Conditions: Amputation
Interventions: DEVICE: Ottobock Kenevo/C-Leg|DEVICE: Ottobock 3R60/3R62
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remote Ischemic Conditioning on Cerebral Small Vessel Disease
Status: UNKNOWN
Conditions: Cerebral Small Vessel Diseases
Interventions: DEVICE: Automatic ischemic conditioning treatment instrument|DRUG: Regular treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed Plus Cisplatin for Brain Metastasis of Advanced Non - Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Pemetrexed, cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation And Varicella Zoster Virus Vaccine Responsiveness In Older Long-Term Care Residents
Status: COMPLETED
Conditions: Immunosenescence|Shingles
Interventions: BIOLOGICAL: Varicella Zoster Virus Vaccine (Zostavax)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess Safety and Efficacy of Odanacatib (MK-0822) in Men With Osteoporosis (MK-0822-053)
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Odanacatib|DRUG: Placebo for Odanacatib|DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Calcium carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Randomized Therapeutic Optimization Trial for Subjects With Refractory Metastatic Colorectal Cancer Using ctDNA: Rapid 1 Trial
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DEVICE: Signatera ctDNA assay|DRUG: pre-specified sequence of FDA-approved drugs and drug combinations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addition of Gemcitabine to Pre Allo-HSCT Conditioning for Acute Lymphoblastic Leukemia
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia, Adult
Interventions: DRUG: Gemcitabine|DRUG: Busulfan|DRUG: Cyclophosphamide|PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Implementation and Biobehavioral Study of Temporomandibular Joint and Muscle Disorder (TMJMD)
Status: COMPLETED
Conditions: Temporomandibular Joint and Muscle Disorder
Interventions: BEHAVIORAL: Biobehavioral|BEHAVIORAL: Active Coping/Attention Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Cognitive & Metacognitive Performance on Knowledge Learning When Conducting Therapeutic Education Programs
Status: COMPLETED
Conditions: Schizophrenia|Bipolar Disorder
Interventions: OTHER: QUESTIONNAIRES
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Navigation of the Pelvic Floor in Bladder Exstrophy Using Pre-operative MRI
Status: COMPLETED
Conditions: Bladder Exstrophy
Interventions: DEVICE: Intraoperative stereotactic imaging with VectorVision
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Value of Fecal Calprotectin in Disorders of the Upper Gastrointestinal Tract
Status: COMPLETED
Conditions: Peptic Esophagitis|Peptic Ulcer|Functional Dyspepsia|Irritable Bowel Syndrome|Inflammatory Bowel Diseases
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Chewing Gum and Mouthwash Before Operation on Sore Throat After General Anesthesia With a Laryngeal Mask
Status: UNKNOWN
Conditions: Postoperative Sore Throat
Interventions: OTHER: chewed mint gum|OTHER: Mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Placebo-Controlled Study of Safety and Effectiveness of Myozyme (Alglucosidase Alfa) in Patients With Late-Onset Pompe Disease
Status: COMPLETED
Conditions: Pompe Disease (Late-onset)|Glycogen Storage Disease Type II (GSD-II)|Acid Maltase Deficiency Disease|Glycogenosis 2
Interventions: BIOLOGICAL: alglucosidase alfa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Atezolizumab and BCG in High Risk BCG naïve Non-muscle Invasive Bladder Cancer (NMIBC) Patients (BladderGATE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Invasive Bladder Cancer
Interventions: DRUG: Atezolizumab|DRUG: BCG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home Blood Pressure Monitoring Trial
Status: COMPLETED
Conditions: Stroke|Ischemic Attack, Transient
Interventions: BEHAVIORAL: Intervention - a validated home BP monitor and support from the specialist nurse|BEHAVIORAL: Control - usual care (BP monitoring by their practice)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Learn the Effect of Drug BAY1817080 on the Way the Body Absorbs, Distributes and Excretes Another Drug Rosuvastatin in Healthy Adult Participants
Status: COMPLETED
Conditions: Drug Interactions
Interventions: DRUG: Rosuvastatin|DRUG: Rosuvastatin + BAY1817080
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: NeutraSal Treatment for Xerostomia in OSAS Patients Using CPAP Therapy
Status: COMPLETED
Conditions: Xerostomia
Interventions: DRUG: NeutraSal|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Short Course Low Dose Oral Colchicine After ST Elevation Myocardial Infarction(STEMI)
Status: RECRUITING
Conditions: STEMI
Interventions: DRUG: Oral Colchicine 0.6 mg|DRUG: Oral Pyridoxine 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Switching From Oral Bisphosphonates to Bazedoxifene to Evaluate Effects on Bone Mineral Density in Postmenopausal Women
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal
Interventions: DRUG: Bazedoxifene|DRUG: Calcium/Vit D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A Phase 1 Study To Evaluate The Effect Of Glasdegib On The Cardiac Repolarization In Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Glasdegib Therapeutic Exposure|DRUG: Glasdegib Supra-therapeutic Exposure|DRUG: Positive Control (Moxifloxacin)|OTHER: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase I Study of HRS-3738 in Recurrent and Refractory Non-Hodgkin's Lymphoma and Multiple Myeloma
Status: RECRUITING
Conditions: Recurrent and Refractory Non-Hodgkin's Lymphoma and Multiple Myeloma
Interventions: DRUG: HRS-3738
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pomalidomide in Combination With High Dose Dexamethasone and Oral Cyclophosphamide
Status: COMPLETED
Conditions: Myeloma
Interventions: DRUG: Pomalidomide|DRUG: Dexamethasone|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic iPSC-derived Cardiomyocyte Therapy in Patients With Worsening Ischemic Heart Failure
Status: RECRUITING
Conditions: Ischemic Heart Failure|Chronic Heart Failure
Interventions: BIOLOGICAL: Human (allogeneic) iPS-cell-derived cardiomyocyte
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine and Docetaxel Therapy in High-risk BCG-naive Patients With Non-muscle Invasive Bladder Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-muscle-invasive Bladder Cancer
Interventions: DRUG: Gemcitabine 1000 mg, Docetaxel 37.5g
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuroprotective Effects of Hypothermia Combined With Inhaled Xenon Following Perinatal Asphyxia
Status: COMPLETED
Conditions: Hypoxic Ischaemic Encephalopathy
Interventions: OTHER: Xenon gas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Trial to Investigate the Efficacy and Safety of Desmopressin for the Treatment of Nocturia in Adult Women
Status: COMPLETED
Conditions: Nocturia
Interventions: DRUG: A. Desmopressin 10 microgram|DRUG: B: Desmopressin 25 microgram|DRUG: C: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Protocol for Herceptin as Adjuvant Therapy With Reduced Exposure to Chemotherapy (PHARE-C)
Status: NOT_YET_RECRUITING
Conditions: HER2-positive Breast Cancer
Interventions: DRUG: Paclitaxel + Trastuzumab|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-center Study to Assess the Effects of BYM338 on Skeletal Muscle in Sarcopenic Adults
Status: COMPLETED
Conditions: Skeletal Muscle
Interventions: DRUG: BYM338|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Therapeutic Footwear and Plantar Orthoses on Diabetic Neuropathic Foot in Quality of Life and Functionality
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Diabetic Peripheral Neuropathy
Interventions: DEVICE: Orthopedic Footwear|DEVICE: Standard Footwear|DEVICE: Plantar Orthoses|BEHAVIORAL: Education on foot self-care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Measurement of Stress During Anesthesia With "Pain Detector" on Patients Receiving Atropine
Status: UNKNOWN
Conditions: Hemorrhoids|Fissure in Ano
Interventions: DRUG: Administration of 0,7 mg of atropine|DEVICE: Measurement of skin conductance with Pain detector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 24-week Trial Comparing GSK573719/GW642444 With GW642444 and With Tiotropium in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK573719/GW642444 125/25|DRUG: GSK573719/GW642444 62.5/25|DRUG: GW642444|DRUG: tiotropium bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Specific Exercise Program During Pregnancy on Diastasis Recti Abdominis
Status: UNKNOWN
Conditions: Diastasis Recti Abdominis|Pregnancy Related
Interventions: OTHER: Specific exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diet for Induction and Maintenance of Remission and Re-biosis in Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: OTHER: Modified Exclusive Enteral Nutrition|OTHER: Crohn's Disease Exclusion Diet|OTHER: Partial Enteral Nutrition|OTHER: Standard Exclusive Enteral Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of DNA Ploidy and Conventional Cytology
Status: UNKNOWN
Conditions: Biopsy, Fine-Needle
Interventions: PROCEDURE: cytology|PROCEDURE: DNA ploidy|PROCEDURE: EUS-FNA|DEVICE: EUS-guided fine needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of SHR-1209 in the Treatment of Hypercholesterolemia and Hyperlipidemia Ⅲ Stage
Status: COMPLETED
Conditions: Primary Hypercholesterolemia|Mixed Hyperlipemia
Interventions: DRUG: SHR-1209|DRUG: SHR-1209 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma
Status: COMPLETED
Conditions: Childhood Burkitt Lymphoma|Childhood Central Nervous System Choriocarcinoma|Childhood Central Nervous System Germ Cell Tumor|Childhood Central Nervous System Germinoma|Childhood Central Nervous System Mixed Germ Cell Tumor|Childhood Central Nervous System Teratoma|Childhood Central Nervous System Yolk Sac Tumor|Childhood Choroid Plexus Tumor|Childhood Craniopharyngioma|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|Childhood Medulloepithelioma|Childhood Meningioma|Childhood Mixed Glioma|Childhood Nasal Type Extranodal NK/T-cell Lymphoma|Childhood Oligodendroglioma|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Brain Stem Glioma|Recurrent Childhood Central Nervous System Embryonal Tumor|Recurrent Childhood Cerebellar Astrocytoma|Recurrent Childhood Cerebral Astrocytoma|Recurrent Childhood Ependymoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Malignant Germ Cell Tumor|Recurrent Childhood Medulloblastoma|Recurrent Childhood Pineoblastoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Childhood Subependymal Giant Cell Astrocytoma|Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor|Recurrent Childhood Visual Pathway and Hypothalamic Glioma|Recurrent Childhood Visual Pathway Glioma|Recurrent/Refractory Childhood Hodgkin Lymphoma|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: vorinostat|DRUG: bortezomib|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Assessment of T4032 (Unpreserved Bimatoprost 0.01%) Versus Lumigan® 0.01% in Ocular Hypertensive or Glaucomatous Patients
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: Bimatoprost Ophthalmic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pravastatin for Hyperlipidaemia in HIV.
Status: COMPLETED
Conditions: HIV Infections|Lipid Metabolism|Glucose Metabolism|Metabolic Abnormality|Lipodystrophy|Cardiovascular Disease
Interventions: DRUG: Pravastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT