pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Potential of Carnosine Supplementation in Reducing the Cardiometabolic Risk
Status: UNKNOWN
Conditions: Insulin Sensitivity
Interventions: DIETARY_SUPPLEMENT: carnosine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Surgical Outcomes After Routine Cataract Extraction & Implantation of a Conventional or Spheric Intraocular Lens
Status: COMPLETED
Conditions: Cataract Extraction
Interventions: DEVICE: Acrysof single piece (SA60AT)|DEVICE: Acrysof IQ (SN60WF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of MT110 in Lung Cancer (Adenocarcinoma and Small Cell), Gastric Cancer or Adenocarcinoma of the Gastro-Esophageal Junction, Colorectal Cancer, Breast Cancer, Hormone-Refractory Prostate Cancer, and Ovarian Cancer
Status: COMPLETED
Conditions: Solid Tumors
Interventions: BIOLOGICAL: MT110
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug-drug Interaction Study Between GLPG1205 and a Cocktail of CYP450 Substrates in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG1205|DRUG: Placebo|DRUG: Cocktail of CYP450 substrates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: End-Stage Kidney Disease Interactive Decision Aid for the Elderly (myKIDNEY)
Status: UNKNOWN
Conditions: End-Stage Kidney Disease
Interventions: OTHER: myKIDNEY decision aid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cardiac Operation Under Totally Endoscope and Cardiopulmonary Bypass (CPB)
Status: UNKNOWN
Conditions: Congenital Heart Defects|Heart Valve Diseases
Interventions: PROCEDURE: cardiac operation with totally endoscopic method
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing Effectiveness of Losartan in Patients With EoE With or Without a CTD
Status: COMPLETED
Conditions: Eosinophilic Esophagitis|Connective Tissue Disorders
Interventions: DRUG: Losartan Potassium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apatinib for Esophageal Squamous Cell Cancer After the Failure of Standard Treatment
Status: COMPLETED
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Apatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of SGN-CD19A for Leukemia and Lymphoma
Status: COMPLETED
Conditions: Burkitt Lymphoma|Precursor B-cell Lymphoblastic Leukemia-Lymphoma
Interventions: DRUG: SGN-CD19A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of a 21day School Brushing Intervention on the Knowledge, Behaviour and Oral Health of School Children
Status: COMPLETED
Conditions: Dental Plaque|Behavior|Behavior, Health
Interventions: BEHAVIORAL: 21 day Brush Day and Night school programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Safety, Pharmacokinetics, and Clinical Activity of Combination of RO6870810 and Venetoclax, With or Without Rituximab, in Participants With Relapsed/Refractory DLBCL and/or High-Grade B-Cell Lymphoma and/or High Grade B-Cell Lymphoma With MYC and/or BCL2 and/or BCL6
Status: COMPLETED
Conditions: Diffuse Large B-cell Lymphoma|High-Grade B-cell Lymphoma
Interventions: DRUG: RO6870810|DRUG: Venetoclax|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cochlear Implant Electrostimulation and the Influence on the Vestibular Organ
Status: COMPLETED
Conditions: Deafness Unilateral|Deafness, Bilateral|Deafness Congenital|Deafness, Acquired
Interventions: DEVICE: Cochlea Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: dexamethasone|DRUG: leucovorin calcium|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: pegaspargase|DRUG: thioguanine|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benefit of IQP-AO-101 for Sleep
Status: COMPLETED
Conditions: Insomnia, Nonorganic
Interventions: DIETARY_SUPPLEMENT: IQP-AO-101|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing Glucose Effects of Sitagliptin (Januvia) in Adult Patients With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Sitagliptin|DRUG: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Fibre Supplementation on Mixed-meal Challenge Response
Status: COMPLETED
Conditions: Health Status
Interventions: OTHER: placebo|DIETARY_SUPPLEMENT: Fibre mixture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Nebulized Hypertonic Saline Treatment in Hospitalized Children With Moderate to Severe Viral Bronchiolitis
Status: COMPLETED
Conditions: Bronchiolitis
Interventions: DRUG: 3% hypertonic saline|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Dietary Guidelines 3 Diet Patterns Study (DG3D): Phase 2
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Obesity
Interventions: BEHAVIORAL: Dietary Intervention Classes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Capsular Contracture After PMRT Using Prepectoral Versus Subpectoral Implant-based Breast Reconstruction: PREPER Trial
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: PROCEDURE: Arm I (Prepectoral), Arm II (Subpectoral)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of PB-119 in Subjects With Type 2 Diabetes and Not Well-controlled by Metformin Monotherapy
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus (T2DM)
Interventions: DRUG: GLP-1 receptor agonist|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Volatile Anesthetic Protection Of Renal Transplants 2
Status: UNKNOWN
Conditions: Delayed Graft Function|Renal Outcome After Kidney Transplantation
Interventions: DRUG: sevoflurane|DRUG: propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Single and Multiple Escalating Doses of Aramchol Administered Under Fed Conditions in Healthy Chinese Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Aramchol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study to Assess Contraceptive Efficacy and Safety of Etonogestrel (ENG) Implant Beyond 3 Years of Use (MK-8415-060)
Status: ACTIVE_NOT_RECRUITING
Conditions: Contraception
Interventions: COMBINATION_PRODUCT: Radiopaque Etonogestrel (ENG) Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Safety Research of Freeze-dried Rabies Vaccine（MRC-5 Cell) in Chinese Humans
Status: COMPLETED
Conditions: Rabies|Healthy
Interventions: BIOLOGICAL: 2.5IU/ml in rabies vaccine （MRC-5 Cell) humans aged 10-20 years old|BIOLOGICAL: 2.5IU/ml rabies vaccine （MRC-5 Cell) in humans aged 21-60 years old|BIOLOGICAL: 2.5IU/ml rabies vaccine （MRC-5 Cell) in humans(from 10-20 years old)|BIOLOGICAL: 2.5IU/ml rabies vaccine （MRC-5 Cell) in humans(from 21-60 years old)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mechanistic Evaluation of Response in TRD (MERIT)
Status: COMPLETED
Conditions: Treatment Resistant Depression|Major Depressive Disorder
Interventions: DRUG: AXS-05|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: OX40, Venetoclax, Avelumab, Glasdegib, Gemtuzumab Ozogamicin, and Azacitidine in Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Anti-OX40 Agonist Monoclonal Antibody PF-04518600|DRUG: Avelumab|DRUG: Azacitidine|DRUG: Gemtuzumab Ozogamicin|DRUG: Glasdegib|DRUG: Glasdegib Maleate|DRUG: Venetoclax|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Insecticide Treated Nets and Wall Liners for the Prevention of Malaria
Status: COMPLETED
Conditions: Malaria
Interventions: OTHER: Insecticide treated nets and wall liners|OTHER: Insecticide treated nets alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bezafibrate for Hyperfibrinogenemia in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Bezafibrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ARGX-117 in Deceased Donor Kidney Transplant Recipients at Risk for Delayed Graft Function
Status: RECRUITING
Conditions: Delayed Graft Function
Interventions: BIOLOGICAL: ARGX-117|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Low Dose OC Therapy in Women With Polycystic Ovary Syndrome (PCOS): Impact of BMI on Hyperandrogenism
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: 3 mg DRSP/20 μg EE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rotational Stability of a Hydrophobic Acrylic Plate Haptic Intraocular Lens Using a Capsular Tension Ring - An Intraindividual Comparative Study
Status: UNKNOWN
Conditions: Intraocular Lens Rotation|Capsular Tension Ring
Interventions: DEVICE: Implantation of an intraocular lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An RCT of a Telemedicine Intervention for Hypokinetic Dysarthria in PD
Status: RECRUITING
Conditions: Parkinson's Disease
Interventions: BEHAVIORAL: Combined speech and exercise intervention|BEHAVIORAL: Health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Tirapazamine Plus Cisplatin in Treating Patients With Persistent or Recurrent Ovarian Epithelial or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: cisplatin|DRUG: tirapazamine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Lamivudine and Therapeutic Vaccine Evaluation in Senegalese Patients With Chronic Hepatitis B Infection (ANRS 12100 HEPADAK-2)
Status: TERMINATED
Conditions: Hepatitis B
Interventions: DRUG: Lamivudine|BIOLOGICAL: Recombinant hepatitis B surface antigen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 89Zr-olaratumab Dosimetry in Participants With Soft Tissue Sarcoma
Status: NOT_YET_RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: 89Zr-DFOsq-olaratumab (89Zr-TLX300-CDx)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: FEnofibRate as a Metabolic INtervention for COVID-19
Status: COMPLETED
Conditions: Covid19
Interventions: OTHER: Fenofibrate/fenofibric acid|OTHER: Placebo|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Working Memory Training on ADHD Brain Function
Status: COMPLETED
Conditions: Attention-Deficit/Hyperactivity Disorder (Combined-subtype)
Interventions: BEHAVIORAL: Working memory training|DEVICE: Functional magnetic resonance imaging (fMRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Connective Tissue Graft Versus Collagen Matrix
Status: ACTIVE_NOT_RECRUITING
Conditions: Buccal Soft Tissue Profile (BSP)
Interventions: PROCEDURE: Soft tissue augmentation at the buccal aspect of single implants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Oral Doses of MYK-461 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: MYK-461|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Anplag® 90mg (Ticagrelor) Tablet & Brilinta® 90 mg (Ticagrelor) Tablet in Healthy Adult Male Pakistani Subjects Under Fasting Condition
Status: COMPLETED
Conditions: Healthy Individuals
Interventions: DRUG: Anplag (Ticagrelor 90 mg)|DRUG: Brilinta (Ticagrelor 90 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparing Interventions for Opioid Dependent Patients Presenting in Medical Emergency Departments
Status: COMPLETED
Conditions: Opioid Dependence
Interventions: BEHAVIORAL: Strengths-based Case Management (SBCM)|BEHAVIORAL: Screening, Assessment, and Referral (SAR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Efficacy of Injectable Hyaluronic Acid for Genitourinary Syndrome of Menopause
Status: COMPLETED
Conditions: Genitourinary Syndrome of Menopause
Interventions: DEVICE: Injectable form of multifractional intercalated cross-linked hyaluronic acid (Armonia®, Regenyal, Italy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total Antioxidant Capacity Before and After HRT in Hypotalamic Amenorrhea
Status: UNKNOWN
Conditions: Hypothalamic Amenorrhea
Interventions: DRUG: 1 mg of transdermal estradiol daily and 10mg of oral MPA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ischemia Care Biomarkers of Acute Stroke Etiology (BASE)
Status: COMPLETED
Conditions: Ischemic Stroke|Atrial Fibrillation|Transient Ischemic Attacks|Transient Cerebrovascular Events|Thrombotic Stroke|Stroke of Basilar Artery|Cardioembolic Stroke
Interventions: OTHER: Biomarker blood draw
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Telehealth-delivered Physical Therapy Program for Postmenopausal Women With Urinary Incontinence
Status: RECRUITING
Conditions: Urinary Incontinence
Interventions: BEHAVIORAL: Pelvic floor muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: a Pilot Study of Pramipexole to Treat Extrapyramidal Symptoms Induced by Antipsychotics
Status: COMPLETED
Conditions: Extrapyramidal Syndrome
Interventions: DRUG: Pramipexole|DRUG: Trihexyphenidyl hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Strongest Families Finland Canada: Family-based Prevention and Treatment Program of Early Childhood Disruptive Behavior
Status: COMPLETED
Conditions: Disruptive Behavior Disorder
Interventions: BEHAVIORAL: Strongest Families
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Investigating the Effects of Beta-Hydroxy-Beta-Methylbutyrate on Glucose Handling in Older and Younger Men.
Status: COMPLETED
Conditions: Insulin Resistance|Age Problems
Interventions: DIETARY_SUPPLEMENT: Beta-Hydroxy-Beta-Methylbutyrate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Phase I Dose Escalation Study of Concomitant BIBF 1120 and BIBW 2992 in Patients With Advanced Solid Tumours.
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: BIBW 2992|DRUG: BIBF 1120
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Different Formulations of Bimatoprost Once-Daily in Patients With Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: Bimatoprost 0.01% ophthalmic solution|DRUG: Bimatoprost 0.015% formulation 1 ophthalmic solution|DRUG: Bimatoprost 0.015% formulation 2 ophthalmic solution|DRUG: Bimatoprost 0.02% ophthalmic solution|DRUG: Bimatoprost 0.03% ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Online Systematic Brief Psychodynamic Psychotherapy for Neurotic Disorders: Randomized Controlled Trial
Status: UNKNOWN
Conditions: Neurotic Disorders
Interventions: BEHAVIORAL: Online Systematic Brief Psychodynamic Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Exercise on Cognitive Performance of Patients With Alzheimer-type Dementia. Pilot Study.
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: OTHER: High intensity aerobic exercise+strength|OTHER: Low intensity aerobic exercise+strength
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pemetrexed as Salvage Treatment in Squamous Cell Carcinoma of Head and Neck
Status: UNKNOWN
Conditions: Squamous Cell Carcinoma of Head and Neck
Interventions: DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Double-blind Confirmatory Trial of Levetiracetam in Epilepsy Patients With Partial Onset Seizures
Status: COMPLETED
Conditions: Epilepsies, Partial
Interventions: DRUG: Levetiracetam 250 mg|DRUG: Levetiracetam 500 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ED-TBI Followed By Allogeneic Stem Cell Transplantation For The Treatment Of Refractory AML And Advanced MDS
Status: SUSPENDED
Conditions: Acute Leukemia|Myelodysplastic Syndrome
Interventions: RADIATION: ED-TBI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alpha-s1 Casein Hydrolysate on Sleep
Status: COMPLETED
Conditions: Chronic Insomnia|Polysomnography
Interventions: DIETARY_SUPPLEMENT: alpha-s1 casein hydrolysate|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Patient-caregiver Collaboration for Better Cardiovascular Care for Patients With Long-term Mental Disorders: Multicentre Qualitative and Feasibility Studies
Status: RECRUITING
Conditions: Long-term Mental Disorders
Interventions: OTHER: Questionnaires (Phase 3)|OTHER: Focus groups (Phase 2)|OTHER: semi-structured interviews (Phase 1)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluate the Effects of Patupilone on the Pharmacokinetics and Pharmacodynamics of Warfarin in Patients With Advanced Malignancies
Status: COMPLETED
Conditions: Advanced Malignancies
Interventions: DRUG: Patupilone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of BEBT-908 in Subjects With Advanced Hematological Tumors
Status: COMPLETED
Conditions: Relapsed or Refractory Non-Hodgkin's Lymphoma|Relapsed or Refractory Multiple Myeloma
Interventions: DRUG: BEBT-908 for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: On-Demand Use of Pantoprazole: Determinants for Chronic Use of Acid Suppressive Medication
Status: UNKNOWN
Conditions: Chronic Use of Acid Suppressive Medication|GORD|GERD|Reflux|Peptic Ulcer
Interventions: DRUG: pantoprazole 20 mg (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab With or Without Elbasvir/Grazoprevir and Ribavirin in Treating Patients With Advanced Refractory Liver Cancer
Status: COMPLETED
Conditions: BCLC Stage B Hepatocellular Carcinoma|BCLC Stage C Hepatocellular Carcinoma|Hepatitis C Infection|Refractory Liver Carcinoma|Stage III Hepatocellular Carcinoma AJCC v7|Stage IIIA Hepatocellular Carcinoma AJCC v7|Stage IIIB Hepatocellular Carcinoma AJCC v7|Stage IIIC Hepatocellular Carcinoma AJCC v7|Stage IV Hepatocellular Carcinoma AJCC v7|Stage IVA Hepatocellular Carcinoma AJCC v7|Stage IVB Hepatocellular Carcinoma AJCC v7
Interventions: DRUG: Elbasvir/Grazoprevir|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinea Plane Block in Pediatric Hip Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Opioid Use
Interventions: PROCEDURE: Real ultrasound-guided single shot erector spinae plane block (ESP B)|RADIATION: Sham ultrasound-guided single shot erector spinae plane block (ESP B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Characterization of Cortical Injury in Early MS Patients: a 7T MRI Study
Status: UNKNOWN
Conditions: Multiple Sclerosis (MS)
Interventions: DEVICE: MRI 7T|OTHER: TEST EDSS|OTHER: TEST MSFC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intraoperative Assessment of Pulsatile Aneurysm Wall Motion During Endovascular Aneurysm Repair
Status: UNKNOWN
Conditions: Abdominal Aortic Aneurysm|Endovascular Abdominal Aortic Aneurysm Repair|Ultrasound
Interventions: DIAGNOSTIC_TEST: Abdominal Aortic Aneurysm Sac Pulsatility
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Conservative Versus Intramedullary Nailing for Pediatric Tibial Shaft Fractures
Status: NOT_YET_RECRUITING
Conditions: Fracture of Tibia
Interventions: PROCEDURE: intramedullary nailing|PROCEDURE: casting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Versus Magnesium Sulphate for Caesarean Delivery
Status: UNKNOWN
Conditions: Cesarean Section
Interventions: DRUG: Bupivacaine|DRUG: Dexmedetomidine|DRUG: Magnesium Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lofexidine ADME & Mass Balance in Volunteers
Status: COMPLETED
Conditions: Normal Healthy Volunteers Will be Treated With Lofexidine to Understand the Absolute Bioavailability and Mass Balance Recovery of the Product
Interventions: DRUG: Lofexidine hydrochloride|DRUG: Lofexidine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Magnesium Supplementation in Stress Conditions
Status: COMPLETED
Conditions: Stress Physiology
Interventions: DIETARY_SUPPLEMENT: Magnesium|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: REWARD: Using the REtina as a Window To Detect Cardiac microvasculAR Dysfunction In Diabetes Mellitus
Status: UNKNOWN
Conditions: Retinopathy, Diabetic|Diastolic Dysfunction|Microalbuminuria
Interventions: DIAGNOSTIC_TEST: Cardiac Assessments and Eye Assessments
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Perioperative Change of Regional Ventilation During Spontaneous Breathing
Status: COMPLETED
Conditions: Pulmonary Infection|Pleural Effusion|Atelectasis|Pneumothorax|Bronchospasm|Aspiration Pneumonitis|Respiratory Insufficiency
Interventions: OTHER: Perioperative pulmonary function tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Efficacy of Oral Antiseptics Against COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Hypochlorous Acid 0.02% Soln,Top (Crystaline) (HClO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Clonidine, Dexmedetomidine, and Fentanyl Adjuncts for Labor Epidural Analgesia
Status: COMPLETED
Conditions: Pregnancy Related
Interventions: DRUG: Clonidine|DRUG: Dexmedetomidine|DRUG: Fentanyl|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Buccal Misoprostol and Intravenous Tranexamic Acid During Emergent Cesarean Delivery
Status: UNKNOWN
Conditions: Cesarean Section Complications
Interventions: DRUG: Misoprostol|DRUG: TA|DRUG: placebo to misoprostol|DRUG: placebo to TA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Analysis of Kinesio® Tape With Manual Fascial Glide Application on Trigger Points in The Iliotibial Band
Status: COMPLETED
Conditions: Myofascial Trigger Point Pain
Interventions: DEVICE: Kinesio® Tape
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analyzing and Solving Exceptional Long-term Survivors in Solid Tumors With Poor Prognosis
Status: RECRUITING
Conditions: Pancreas Adenocarcinoma|Small-cell Lung Cancer|Glioblastoma, IDH-wildtype
Interventions: GENETIC: Long term survival multimodal analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cytotoxicity Induced by Tumor Lysate Pulsed Dendritic Cells Against Autologous Hepatocellular Carcinoma Cells
Status: UNKNOWN
Conditions: Carcinoma, Hepatocellular
Interventions: BIOLOGICAL: DC vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bosutinib in Treating Patients With Chronic Myeloid Leukemia in Chronic Phase After Frontline TKI Failure
Status: TERMINATED
Conditions: Blasts Under 15 Percent of Bone Marrow Nucleated Cells|Blasts Under 15 Percent of Peripheral Blood White Cells|Blasts Under 30 Percent of Bone Marrow Nucleated Cells|Blasts Under 30 Percent of Peripheral Blood White Cells|Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Interventions: DRUG: Bosutinib|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali
Status: COMPLETED
Conditions: Lymphedema|Lymphatic Filariasis|Filariasis
Interventions: DRUG: Doxycycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diet and Physical Activity on NAFLD and Erytrocyte Membrane Lipid Profile.
Status: UNKNOWN
Conditions: NAFLD
Interventions: BEHAVIORAL: Control|BEHAVIORAL: LGIMD|BEHAVIORAL: Endurance Activity (EA)|BEHAVIORAL: EA+Resistance Training (RT)|BEHAVIORAL: LGIMD+EA|BEHAVIORAL: LGIMD+EA/RT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trem-1 and Ultraviolet Radiation-induced Immune Suppression
Status: ACTIVE_NOT_RECRUITING
Conditions: Skin Diseases
Interventions: DRUG: Diphenylcyclopropenone (DPCP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Retrospective Study in Patients Receiving Two or More OZURDEX® Injections for Retinal Vein Occlusion (RVO)
Status: COMPLETED
Conditions: Retinal Vein Occlusion|Macular Edema
Interventions: DRUG: dexamethasone intravitreal implant 0.7 mg
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Foley Catheter Versus Dinoprostone Vaginal Insert for Induction of Labor in Parous Women at Term: A Randomized Trial
Status: COMPLETED
Conditions: Failed Induction of Labor
Interventions: DEVICE: Transcervical foley catheter|DRUG: Dinoprostone 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Working Memory in Patients With Early Alzheimer's Disease Through the Use of rTMS
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: PROCEDURE: Repetitive Transcranial Magnetic Stimulation|PROCEDURE: Repetitive Transcranial Magnetic Stimulation - Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Group Therapy for Fibromyalgia:the Effectiveness of Mindfulness -Based VS Cognitive-behavioral Therapy
Status: COMPLETED
Conditions: Fibromyalgia|PTSD|Depression|Stress|Sleep Disturbance
Interventions: OTHER: cognitive behavioral group therapy|OTHER: Mindfulness-based group therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Homeopathy for Overweight and Obesity in Mexican Adolescents
Status: UNKNOWN
Conditions: Overweight and Obesity
Interventions: DRUG: Homeopathic Medication|OTHER: Multidisciplinary intervention (Exercise program, diet, motivational support)|DRUG: Homeopathic placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for Use of Physical Therapy in Treatment
Status: RECRUITING
Conditions: Adhesive Capsulitis|Frozen Shoulder|Shoulder Frozen
Interventions: OTHER: Physical Therapy|DRUG: Depot Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long-term Safety and Tolerability Study of Ezetimibe Plus Atorvastatin in Participants With Coronary Heart Disease, Multiple Risk Factors, or Hypercholesterolemia Not Controlled by Atorvastatin (P01418/MK-0653-032)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Ezetimibe|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improvement of Postoperative Immunosuppression in Patients Receiving Coronary Artery Bypass Grafting by TEAS
Status: COMPLETED
Conditions: Immunosuppression
Interventions: DEVICE: TEAS+GA group|DEVICE: Sham TEAS+GA group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Trial for Heart Failure Care
Status: RECRUITING
Conditions: Heart Failure|Heart Failure With Reduced Ejection Fraction
Interventions: BEHAVIORAL: Multiprong CDS with referral to pharmacist co-management|BEHAVIORAL: Multiprong CDS with GDMT order set|BEHAVIORAL: Focused education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: TACE Combined With "Target Immune" Therapy for First-line Treatment in the Treatment of Intrahepatic Cholangiocarcinoma
Status: UNKNOWN
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: PROCEDURE: Transcatheter arterial chemoembolization|DRUG: Multi-target Drug Therapy|DRUG: Immunocheckpoint Inhibitor Therapy|PROCEDURE: Systemic Intravenous Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Utility of a Novel Eye Shield With Reusable Adhesive Anchors for Post-operative Care After Ophthalmic Surgery
Status: RECRUITING
Conditions: Cataract; Eye Disease
Interventions: DEVICE: Novel "Snaps" Eye Shield|OTHER: Standard Alcon Eye Shield
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Lateral Wedge Insoles With Arch Support in Knee Osteoarthritis
Status: COMPLETED
Conditions: Medial Knee Osteoarthritis
Interventions: DEVICE: Neutral customized foot orthoses|DEVICE: 6° lateral customized foot orthoses|DEVICE: 10° lateral customized foot orthoses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Apatinib Plus XELOX as Neoadjuvant Therapy in Locally Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Chemotherapy Effect|Chemotherapeutic Toxicity|Gastric Cancer
Interventions: DRUG: Apatinib plus XELOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraarticular Xylitol Injections for Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Xylitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Success of Titration, Analgesics, and B.E.T.A Nurse Support on Acceptance Rates in Early Multiple Sclerosis (MS) Treatment With Betaseron
Status: COMPLETED
Conditions: Multiple Sclerosis|Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Interferon-1beta (Betaseron, BAY86-5046)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transition to Home (TtH) After Preterm Birth
Status: UNKNOWN
Conditions: Preterm Birth
Interventions: BEHAVIORAL: neonatologists|BEHAVIORAL: psychological support|BEHAVIORAL: lactation consultant|BEHAVIORAL: physiotherapeutic interventions|BEHAVIORAL: social workers|BEHAVIORAL: music therapy|BEHAVIORAL: other health care professionals|BEHAVIORAL: interprofessional roundtable meetings|BEHAVIORAL: Advanced practice nurses' interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Functional Exercise Versus High Frequency Transcutaneous Electrical Nerve Stimulation on Primary Dysmenorrhea
Status: COMPLETED
Conditions: Primary Dysmenorrhea
Interventions: OTHER: Functional Exercise|OTHER: High Frequency Transcutaneous Electrical Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Thyroid Exposure to Radiation Doses During Paediatric Cardiac Catheterisations Performed for Diagnosis or the Treatment of Congenital Heart Disease
Status: COMPLETED
Conditions: Cardiac Catheterizations
Interventions: OTHER: blood and urine samples ; Echography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Smartphone Assisted Self-management Education for Adult Burn Patient at Aftercare
Status: RECRUITING
Conditions: Burns|Self Efficacy|Burn Second Degree|Burns Third Degree|Quality of Life|Adherence, Treatment|Burn Injury
Interventions: BEHAVIORAL: Self Management Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Therapy of Peri-implantitis: Scaling Versus Low Abrasive Powder
Status: UNKNOWN
Conditions: Peri-implantitis
Interventions: PROCEDURE: Air abrasion of the implant surface with a low abrasive powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prehospital TEE in Cardiac Arrest
Status: UNKNOWN
Conditions: Echocardiography, Transesophageal|Out-of-Hospital Cardiac Arrest
Interventions: DEVICE: Transesophageal Echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Study the Signs of Ocular Degeneration in a Population Cohort (Dijon 3C Montrachet Cohort)
Status: COMPLETED
Conditions: AMD|Glaucoma
Interventions: PROCEDURE: Optical Coherence Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Longitudinal Outcomes Study of the Subchondroplasty® Procedure in the Foot/Ankle
Status: COMPLETED
Conditions: Insufficiency Fractures|Stress Fracture|Stress Fracture, Ankle, Foot and Toes
Interventions: DEVICE: Treatment of insufficiency fractures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Does Ranolazine Decrease Biomarkers of Myocardial Damage in Diabetics
Status: WITHDRAWN
Conditions: Silent Myocardial Ischemia|Type 2 Diabetes
Interventions: DRUG: Ranolazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study Comparing PF-06273340 Immediate Release Tablet, PF-06273340 Modified Release Tablets To PF-06273340 Oral Solution In The Fasted State. This Study Will Also Compare PF-06273340 Modified Release Tablets In Fasted And Fed State
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06273340|DRUG: PF-06273340|DRUG: PF-06273340|DRUG: PF-06273340|DRUG: PF-06273340|DRUG: PF-06273340
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Doses of IVIG for Kawasaki Disease
Status: COMPLETED
Conditions: Kawasaki Disease
Interventions: DRUG: IVIG (1g/kg,once)|DRUG: IVIG (1g/kg,twice)|DRUG: IVIG (2g/kg.once)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluorescence Angiography in the Assessment of DIEP Flap Perfusion
Status: COMPLETED
Conditions: Breast Cancer|Vascularization|Fat Necrosis
Interventions: PROCEDURE: Tailoring the flap according to clinical assessment|PROCEDURE: Tailoring the flap according to ICG Angiography assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Testing a Nature-based Social Intervention on Loneliness: the RECETAS-BCN Trial
Status: RECRUITING
Conditions: Loneliness
Interventions: BEHAVIORAL: Nature-based social intervention (NBSI)|BEHAVIORAL: Usual care + menu with nature-based activities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hematopoietic Stem Cell Transplant for Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease|Sickle Cell Anemia|SCD
Interventions: DRUG: Fludarabine|PROCEDURE: Hematopoietic Stem Cell Transplant (HSCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Umbilical Cord-Derived Wharton's Jelly Stem Cells for the Treatment of Acute Graft Versus Host Disease
Status: RECRUITING
Conditions: Acute Graft Versus Host Disease
Interventions: BIOLOGICAL: MSCTC-0010 Dose Escalation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Experience With Descemet's Stripping Automated Endothelial Keratoplasty
Status: COMPLETED
Conditions: Corneal Edema Secondary to Corneal Endothelial Dystrophy
Interventions: PROCEDURE: DSAEK|DIAGNOSTIC_TEST: Anterior Segment Optical Coherence Topography (OCT)|DIAGNOSTIC_TEST: Best Spectacle Corrected Visual Acuity (BSCVA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Probiotic Supplementation to Improve the GUT Microbiota of Very Low Birth Weight Preterm, a Pilot Study
Status: COMPLETED
Conditions: Other Preterm Infants|NEC
Interventions: DIETARY_SUPPLEMENT: Probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Weekly Doses of Cilengitide and Paclitaxel in Treating Patients With Advanced Solid Tumors That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Adult Solid Neoplasm|Estrogen Receptor Negative|HER2/Neu Negative|Male Breast Carcinoma|Progesterone Receptor Negative|Recurrent Breast Carcinoma|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer|Triple-Negative Breast Carcinoma
Interventions: DRUG: Cilengitide|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Tecemotide (L-BLP25) in Non-Small Cell Lung Cancer (NSCLC) Subjects With Unresectable Stage III Disease
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung|Lung Neoplasms
Interventions: BIOLOGICAL: Tecemotide (L-BLP25)|DRUG: Single low dose cyclophosphamide|OTHER: Best standard of care (BSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Adhesion and Dermal Tolerability of EMSAM
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: EMSAM (Selegiline Transdermal System) 6mg/24Hr|DRUG: EMSAM (Selegiline Transdermal System) 9mg/24Hr|DRUG: EMSAM (Selegiline Transdermal System) 12mg/24hr
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Safety and Efficacy Study of Nimotuzumab Plus Neoadjuvant and Concurrent Chemoradiotherapy to Treat Oropharynx and Hypopharynx Cancer
Status: UNKNOWN
Conditions: Oropharyngeal Cancer|Hypopharyngeal Cancer
Interventions: DRUG: docetaxel and cisplatin|RADIATION: IMRT|BIOLOGICAL: Nimotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The AttenueX IntraVesical System for the Treatment of Female Stress Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence, Stress
Interventions: DEVICE: AttenueX IntraVesical System|PROCEDURE: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT