pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study Evaluating the Safety, Pharmacokinetics, and Activity of the Combination of Cevostamab and Elranatamab in Participants With Relapsed or Refractory Multiple Myeloma (R/R MM)
Status: RECRUITING
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: DRUG: Cevostamab|DRUG: Elranatamab|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Nutritional Supplementation in Malnourished Patients in Stable COPD
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease(COPD)|Malnutrition
Interventions: DIETARY_SUPPLEMENT: enteral nutrition emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 4-Week Study to Assess the Effect of Alendronate and Vitamin D3 Once Weekly on Fractional Calcium Absorption in Postmenopausal Osteoporotic Women (0217A-230)
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: alendronate sodium (+) cholecalciferol|DRUG: Comparator: Placebo (unspecified)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Stepped Care for Suicide Prevention in Teens and Young Adults
Status: COMPLETED
Conditions: Suicidal Behavior|Self-Harm, Deliberate|Suicidal Ideation|Suicide
Interventions: BEHAVIORAL: Stepped Care for Suicide Prevention|BEHAVIORAL: Zero Suicide Quality Improvement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of PIEB vs CEI for Labor Analgesia
Status: COMPLETED
Conditions: Labor Pain
Interventions: OTHER: Programmed Intermittent Epidural Bolus|OTHER: Continuous Epidural Infusion|DRUG: Ropivacaine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Platelet-rich Plasma Combined With Conventional Surgery in the Treatment of Atrophic Nonunion of Femoral Shaft Fractures
Status: UNKNOWN
Conditions: Nonunion of Fracture
Interventions: PROCEDURE: conventional surgery|PROCEDURE: autologous platelet-rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Stigma Among Healthcare Providers to Improve Mental Health Services
Status: COMPLETED
Conditions: Mental Disorders
Interventions: BEHAVIORAL: RESHAPE|BEHAVIORAL: PRIME/mhGAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of the Integrated-based Laughing Qigong Program on Resilience in Community-dwelling Older Adults
Status: COMPLETED
Conditions: Community-dwelling Older Adults
Interventions: BEHAVIORAL: Integrated-based Laughing Qigong Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Improving Cardiovascular Health Risks in Adults With Epilepsy on a Modified Atkins Diet
Status: NOT_YET_RECRUITING
Conditions: Epilepsy|Dyslipidemia
Interventions: DRUG: Atorvastatin 10mg|OTHER: Modification of dietary fat composition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Surgical Correction of Anterior Vertical Maxillary Excess (Gummy Smile) by Compression Osteogenesis.
Status: COMPLETED
Conditions: Compression Osteogenesis
Interventions: PROCEDURE: Corticotomy followed by compression osteogenesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closure of Mucosal and Submucosal Defects in the Gastrointestinal Tract Using the Novel X-Tack Endoscopic Suturing Device
Status: COMPLETED
Conditions: Polyp of Colon|Fistula
Interventions: DEVICE: X-Tack|DEVICE: Overstitch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Early Childhood : Action Research in the Lunévillois Area (PERL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Development, Infant|Perinatal Disorder
Interventions: OTHER: Psychologist's evaluation|OTHER: Pediatric Nurse's interventions|OTHER: Joint home visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of Fibrin Sealant With 4 IU/mL Thrombin, Vapor Heated, Solvent Detergent Treated (FS VH S/D 4) in Face-Lift Procedures
Status: COMPLETED
Conditions: Facial Rhytidectomy (Face-lift)
Interventions: BIOLOGICAL: Fibrin Sealant with 4 IU/ml Thrombin, Vapor-Heated, Solvent Detergent Treated Containing Synthetic Aprotinin (FS VH S/D 4)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib Hydrochloride Before Surgery in Treating Patients With Stage III Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Stage IIIA Non-Small Cell Lung Cancer|Stage IIIB Non-Small Cell Lung Cancer
Interventions: DRUG: Erlotinib Hydrochloride|PROCEDURE: Therapeutic Conventional Surgery|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of an Antioxidant Dressing in Chronic Wound Healing
Status: COMPLETED
Conditions: Hard-to-heal Wounds
Interventions: DEVICE: Antioxidant dressing (active product)|DEVICE: Usual care dressing that create a moist environment (standard clinical practice)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy and MK-3475 for Patients With Recurrent/Metastatic Head and Neck Cancer, Renal Cell Cancer, Melanoma, and Lung Cancer
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma|Metastatic Renal Cell Cancer|Recurrent Head and Neck Carcinoma|Recurrent Lung Carcinoma|Recurrent Renal Cell Carcinoma|Recurrent Skin Carcinoma|Stage III Renal Cell Cancer|Stage IV Lung Cancer|Stage IV Skin Melanoma
Interventions: RADIATION: Radiation Therapy (RT)|DRUG: MK-3475
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Confirming the Efficacy/Mechanism of Family Therapy for Children With Low Weight ARFID
Status: RECRUITING
Conditions: Avoidant/Restrictive Food Intake Disorder
Interventions: BEHAVIORAL: Family-based Treatment for ARFID|BEHAVIORAL: Manualized Non-Specific Usual Care for ARFID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Orally Administered BEZ235 Monotherapy in Patients With Metastatic or Unresectable Malignant PEComa
Status: WITHDRAWN
Conditions: Malignant PEComa (Perivascular Epithelioid Cell Tumors)
Interventions: DRUG: BEZ235
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Epidural Versus Intravenous Local Anesthetic Infusion in Open Upper Abdominal Surgery
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: Bupivacaine|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Trastuzumab Emtansine in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer Who Have Received Prior Anti-HER2 And Chemotherapy-based Treatment
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab Emtansine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study to Evaluate the Bioequivalence of 2 Progesterone Vaginal Rings in Postmenopausal Women
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Progesterone vaginal ring,
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: InTake Care: Development and Validation of an Innovative, Personalized Digital Health Solution for Medication Adherence Support in Cardiovascular Prevention
Status: NOT_YET_RECRUITING
Conditions: Hypertension|Treatment Adherence and Compliance|Digital Health
Interventions: OTHER: adherence support system based on a vocal assistant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Avastin (Bevacizumab) to Reverse Acquired Estrogen Independence in Previously Hormone Responsive Metastatic Breast Ca.
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Avastin|DRUG: Hormonal therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects Of Passive Smoking On The Respiratory System Mechanics Of Healthy Non-Smokers In Different Body Positions
Status: COMPLETED
Conditions: PASSIVE SMOKING ,|RESPIRATORY SYSTEM MECHANICS,
Interventions: OTHER: exposed to a smoking environment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Healthy Subjects and Adult and Elderly Subjects With Mild Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Healthy Subjects
Interventions: DRUG: Placebo|DRUG: Lemborexant 10 mg|DRUG: Lemborexant 25 mg|DRUG: Placebo|DRUG: Lemborexant 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Prospective Comparative Study of the Efficacy of Common Antipyretic Treatments in Febrile Children
Status: UNKNOWN
Conditions: Fever
Interventions: DRUG: Ibuprofen|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Molecular Testing for the MD Anderson Cancer Center Personalized Cancer Therapy Program
Status: RECRUITING
Conditions: Glioma|Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm|Melanoma|Sarcoma
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Genetic Testing|OTHER: Medical Chart Review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Subgingival Erythritol Air Polishing in Treatment of Periodontal Pockets
Status: ACTIVE_NOT_RECRUITING
Conditions: Periodontal Diseases
Interventions: PROCEDURE: Subgingival erythritol air polishing|PROCEDURE: Conventional root planing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perception of Facial Emotions in Schizophrenia and 22q11 Deletion Syndrome
Status: COMPLETED
Conditions: Schizophrenia
Interventions: OTHER: schizophrenia|OTHER: the 22q11 deletion syndrome|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Recombinant Interleukin 21 in Combination With Rituxan for Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: recombinant human interleukin 21 and rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Percutaneous Neuromodulation Versus Dry Needling in Shoulder Pain Treatment
Status: COMPLETED
Conditions: Shoulder Pain
Interventions: OTHER: Ultrasound-guided percutaneous neuromodulation (NMPE)|OTHER: Ultrasound-guided dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Level III Support Procedure on Enlarged Genital Hiatus After Minimally Invasive Sacrocolpopexy
Status: ACTIVE_NOT_RECRUITING
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: Level III support procedure|PROCEDURE: Minimally Invasive Sacrocolpopexy|OTHER: Transperineal ultrasound of the Pelvic Floor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quaratusugene Ozeplasmid (Reqorsa) and Atezolizumab Maintenance Therapy in ES-SCLC Patients
Status: RECRUITING
Conditions: Small Cell Lung Cancer Extensive Stage
Interventions: BIOLOGICAL: quaratusugene ozeplasmid|BIOLOGICAL: atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Approach to Ankle Sprains in the Emergency Department
Status: COMPLETED
Conditions: Ankle Sprains
Interventions: DRUG: Dexketoprofen Trometamol 50 Mg/mL Solution for Injection|DRUG: Ibuprofen 100 MG/ML Solution for Injection|DRUG: Paracetamol 10 Mg/mL Solution for Injection|DRUG: isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Evaluating Fispemifene in the Treatment of Hypogonadal Men With Erectile Dysfunction Unresponsive to PDE5 Inhibitors
Status: COMPLETED
Conditions: Hypogonadism|Erectile Dysfunction
Interventions: DRUG: Fispemifene (once daily for 8 weeks)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effect of Candesartan vs Placebo in Prevention of Trastuzumab-associated Cardiotoxicity
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: AT1 blocker candesartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuroinflammation, Affective and Cognitive Symptoms in Major Depression and Psoriasis
Status: WITHDRAWN
Conditions: Psoriasis|Neuroinflammation|Major Depressive Disorder|Cognitive Symptom|Immunological Abnormality
Interventions: DIAGNOSTIC_TEST: Sociodemographic variables
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Behavioral Economic Treatment to Enhance Rural (BETTER) Living
Status: COMPLETED
Conditions: Alcohol Use, Unspecified
Interventions: BEHAVIORAL: Episodic Future thinking|BEHAVIORAL: Volitional choice|BEHAVIORAL: Monitoring only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dry Needling Treatment in Hemiplegic Shoulder Pain
Status: COMPLETED
Conditions: Hemiplegia|Shoulder Pain|Myofascial Pain
Interventions: OTHER: Conventional physical therapy|OTHER: Conventional physical therapy plus dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Efficacy and Safety of Formoterol Fumarate 20 Mcg/0.5 mL in the Treatment of Patients With COPD
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Formoterol Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Sleep Disturbances in the 2nd and 3rd Trimester
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders|Sleep|Sleep Apnea|Sleep Disorder|Sleep Disturbance|Sleep Apnea, Obstructive|Pregnancy Related|Pregnancy
Interventions: OTHER: Patient-reported scales to measure sleep disorders
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Effect of Fucoidan on Prostate Health in Males With Benign Prostatic Hyperplasia
Status: NOT_YET_RECRUITING
Conditions: Benign Prostatic Hyperplasia
Interventions: DIETARY_SUPPLEMENT: Fucoidan extracted from Undaria pinnatifida (UPF)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinical Evaluation of Robot-assisted Cochlear Implant Insertion in Adults Using RobOtol® Compared to Manual Insertion
Status: RECRUITING
Conditions: Profound Bilateral Hearing Loss
Interventions: PROCEDURE: Cochlear implant manual insertion|PROCEDURE: Cochlear implant robotized insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Teen Adherence in KidnEy Transplant Improving Tracking To Optimize Outcomes - Stage 3
Status: COMPLETED
Conditions: Medication Adherence|Kidney Transplantation
Interventions: BEHAVIORAL: Adherence Intervention|OTHER: Healthy living education intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Strength Training for Osteoporosis Prevention During Early Menopause
Status: RECRUITING
Conditions: Bone Loss|Bone Loss, Age-related|Osteoporosis|Musculoskeletal Diseases
Interventions: OTHER: Resistance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: IMPACT - AndHealth Autoimmune Research Registry
Status: RECRUITING
Conditions: Arthritis, Rheumatoid|Arthritis, Psoriatic|Psoriasis|Ankylosing Spondylitis|Autoimmune Diseases
Interventions: OTHER: Root-cause autoimmune treatment program
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prenatal Treatment of Congenital Cytomegalovirus Infection with Letermovir Versus Valaciclovir
Status: RECRUITING
Conditions: Pregnant Women|CMV Infected Fetuses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase II Efficacy Study Comparing 2',3'-Dideoxyinosine (ddI) (BMY-40900) and Zidovudine Therapy of Patients With HIV Infection Who Have Been on Long Term Zidovudine Treatment
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zidovudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Preventive Remediation for Optimal MEdical StudentS (PROMESS)
Status: ENROLLING_BY_INVITATION
Conditions: Health Behavior|Health-Related Behavior
Interventions: BEHAVIORAL: Stress management, sleep improvement and fatigue reduction, sedentary behaviors reduction and physical activity promotion.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of QL1706 (an Anti-PD-1/CTLA-4 Combined Antibody) Combined With Albumin-bound Paclitaxel and Bevacizumab in the Treatment of Platinum-resistant Recurrent Ovarian Cancer
Status: NOT_YET_RECRUITING
Conditions: Platinum-resistant Recurrent Ovarian Cancer
Interventions: DRUG: QL1706
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of High Cheese Consumption on Metabolic Syndrome Risk Factors
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: High-fat cheese|DIETARY_SUPPLEMENT: Low-fat cheese|DIETARY_SUPPLEMENT: No-cheese/carbohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Induction and Maintenance Treatment With MabThera (Rituximab) in Patients With Indolent B-Cell Nonfollicular Lymphomas
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel, Prednisone, and Vatalanib in Treating Patients With Advanced Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: docetaxel|DRUG: prednisone|DRUG: vatalanib
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Probiotic Supported Yogurt Consumption on Gastrointestinal Symptoms
Status: NOT_YET_RECRUITING
Conditions: Gastrointestinal Dysfunction
Interventions: DIETARY_SUPPLEMENT: Activia Probiotic Yogurt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction Study Between AT1001 (Migalastat Hydrochloride) and Agalsidase in Participants With Fabry Disease
Status: COMPLETED
Conditions: Fabry Disease
Interventions: DRUG: Migalastat HCl|BIOLOGICAL: Agalsidase Beta|BIOLOGICAL: Agalsidase Alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment With the Anti-IgE Monoclonal Antibody Omalizumab in Women With Asthma Undergoing Fertility Treatment. - A Proof of Concept Study.
Status: ACTIVE_NOT_RECRUITING
Conditions: Asthma|Infertility, Female
Interventions: DRUG: Omalizumab Injection|DRUG: NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Glucosamine and Chondroitin Sulfate Supplementation in Addition to Resistance Exercise Training and Manual Therapy in Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis|Osteoarthritis, Knee
Interventions: DIETARY_SUPPLEMENT: Chondroitin Sulfate|PROCEDURE: Resistance exercise training|PROCEDURE: Manual therapy / Joint Mobilization|PROCEDURE: THE therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Novel Sound Changing Principles in Hearing Instruments to Determine Their Application - 2018_16
Status: COMPLETED
Conditions: Hearing Loss|Normal Hearing
Interventions: DEVICE: Hearing Aid without NR and BF|DEVICE: Hearing Aid with NR|DEVICE: Hearing Aid with BF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of IDP-124 Lotion for the Treatment of Moderate to Severe Atopic Dermatitis in Pediatric and Adult Subjects (301)
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: IDP-124 Lotion|DRUG: IDP-124 Vehicle Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Triapine as First-Line or Second-Line Therapy in Treating Patients With Locally Advanced or Metastatic Cancer of the Pancreas
Status: COMPLETED
Conditions: Acinar Cell Adenocarcinoma of the Pancreas|Duct Cell Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage III Pancreatic Cancer|Stage IV Pancreatic Cancer
Interventions: DRUG: triapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Tramadol Hydrochloride /Paracetamol Tablets Versus Ultracet Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ultracet Tablets|DRUG: Tramadol hydrochloride 37.5 mg/Paracetamol 325 mg tablets - tablet (Pfizer)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Tanezumab in Osteoarthritis Of The Hip
Status: COMPLETED
Conditions: Arthritis|Osteoarthritis|Osteoarthritis, Hip
Interventions: BIOLOGICAL: tanezumab|BIOLOGICAL: tanezumab|BIOLOGICAL: tanezumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ivabradine on Microcirculation and Cardiac Output in Septic Shock Patients
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: Ivabradine 5mg Tab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Angiomax® or Unfractionated Heparin for Patients Undergoing Percutaneous Coronary Intervention
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: DRUG: Bivalirudin|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Supraclavicular Brachial Plexus Block During Upper Limb Surgeries
Status: COMPLETED
Conditions: Brachial Plexus Block
Interventions: DRUG: Bupivacaine-ketamine injection|DRUG: Bupivacaine injection with intravenous ketamine infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Rhythm Control Versus Rate Control for New Onset Atrial Fibrillation
Status: TERMINATED
Conditions: Atrial Fibrillation New Onset|Atrial Fibrillation Paroxysmal
Interventions: DRUG: Amiodarone, diltiazem or esmolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact Study of Workplace Mental Health Education on Early Intervention for Healthcare Workers With Mental Health Issues
Status: COMPLETED
Conditions: Mental Health Impairment
Interventions: BEHAVIORAL: Beyond Silence|BEHAVIORAL: Mental Health First Aid (MHFA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Particle-based Partial Tumor Irradiation of Unresectable Bulky Tumors
Status: RECRUITING
Conditions: Cancer
Interventions: RADIATION: Particle radiotherapy|DIAGNOSTIC_TEST: Magnetic resonance imaging|DIAGNOSTIC_TEST: Computertomography|DIAGNOSTIC_TEST: Copper-64-Diacetyl-bis (N4-methylthiosemicarbazone) Positron Emission Tomography-Computer Tomography (64Cu-ATSM-PET-CT)|DIAGNOSTIC_TEST: 18-F-FluorDesoxyGlukose Positron Emission Tomography-Computer Tomography (18F-FDG-PET-CT)|DIAGNOSTIC_TEST: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mitoxantrone and Prednisone With or Without Leflunomide in Treating Patients With Stage IV Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: leflunomide|DRUG: mitoxantrone hydrochloride|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of Pre-operative Combination Therapy With Mogamulizumab and Nivolumab Against Solid Cancer Patients
Status: COMPLETED
Conditions: Gastric Cancer|Esophageal Cancer|Lung Cancer|Renal Cancer|Oral Cancer
Interventions: BIOLOGICAL: Mogamulizumab|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Assess the Effectiveness of BehaviouRal ActiVation Group Program in Patients With dEpression: BRAVE
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Behavioral Activation|BEHAVIORAL: Support Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of TG6002 (VV TK-RR-FCU1) in Combination With 5-FC in Patients With Advanced Gastro-intestinal Tumors.
Status: TERMINATED
Conditions: Colorectal Neoplasm|Digestive System Neoplasm
Interventions: BIOLOGICAL: TG6002|DRUG: Flucytosine (5-FC, Ancotil)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Acetazolamide With Temozolomide in Adults With Newly Diagnosed or Recurrent Malignant Glioma
Status: RECRUITING
Conditions: Malignant Glioma of Brain
Interventions: DRUG: Acetazolamide|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effectiveness of Administration of Meperidine on the Length of Active Phase of Labor in Women
Status: COMPLETED
Conditions: Labor Pain
Interventions: DRUG: Meperidine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Consequences of Obstetric Anal Sphincter Injuries on Maternal Psychology and Relationship Experience
Status: RECRUITING
Conditions: Obstetric Complication|Obstetric Trauma|Perineal Tear|Incontinence|Mental Health Impairment|Relation, Family|Relation, Mother-Child
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immediate Load in Dental Implants Using Conventional Drilling and Piezoelectric Osteotomy on Aesthetic Zone.
Status: UNKNOWN
Conditions: Dental Implants|Tooth Loss
Interventions: PROCEDURE: Piezoelectric osteotomy.|PROCEDURE: Conventional drilling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Total Knee Replacement TIVA With Robotic Arm Assisted
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: DRUG: Propofol|DRUG: Sevoflurane|PROCEDURE: Spinal anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Intra-subject Variability of Pharmacokinetics of Lomitapide in Healthy Subjects
Status: COMPLETED
Conditions: Intra-subject Variability of Pharmacokinetics
Interventions: DRUG: lomitapide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Tri-split Face Study of Skin Resurfacing Modalities for the Treatment of Melasma
Status: WITHDRAWN
Conditions: Melasma
Interventions: DRUG: 22% TCA peel|DEVICE: CO2 laser|DEVICE: Qs-NdYag laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Theta Burst Stimulation on the Brain, Behavior, and Clinical Symptoms in Adults With Bipolar Disorder
Status: RECRUITING
Conditions: Bipolar Disorder
Interventions: DEVICE: Continuous Theta Burst Stimulation (cTBS)|DEVICE: Sham Continuous Theta Burst Stimulation (Sham cTBS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evalutation of Insulin Sensitivity Through Hyperinsulinemic Clamp in Children With GH Deficiency
Status: COMPLETED
Conditions: Growth Hormone Deficiency
Interventions: DIAGNOSTIC_TEST: euglycemic hyperinsulinemic clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nivolumab Plus Ipilimumab as Neoadjuvant Therapy for Hepatocellular Carcinoma (HCC)
Status: COMPLETED
Conditions: Hepatocellular Carcinoma (HCC)
Interventions: DRUG: nivolumab, ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Phototoxic Potential of Faldaprevir
Status: WITHDRAWN
Conditions: Healthy
Interventions: DRUG: Faldaprevir high dose|DRUG: Placebo|DRUG: Ciprofloxacin|DRUG: Faldaprevir low dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of the Combined Extract of Lemon Verbena and Hibiscus on Health Indicators
Status: RECRUITING
Conditions: Diet, Mediterranean|Antioxidant Effect|Body Weight|Cardiovascular Diseases|Densitometry|Body Composition
Interventions: DIETARY_SUPPLEMENT: Metabolaid(R)|DIETARY_SUPPLEMENT: Nutraceutical placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Fluocinolone Acetonide Intravitreal Implant vs Standardized Therapy
Status: COMPLETED
Conditions: Non-infectious Uveitis
Interventions: DRUG: fluocinolone acetonide intravitreal implant|DRUG: corticosteroids and immunosuppressants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Study of Isavuconazole and Midazolam
Status: COMPLETED
Conditions: Pharmacokinetics of Isavuconazole|Pharmacokinetics of Midazolam|Healthy Volunteers
Interventions: DRUG: Isavuconazole|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Resin Infiltration Treatment Versus a Combined Treatment With Microabrasion for the Management of MIH Affected Incisors
Status: UNKNOWN
Conditions: Molar Incisor Hypomineralization
Interventions: OTHER: Resin infiltration and microabrasion for MIH-affected incisors|OTHER: Resin infiltration for MIH-affected incisors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Routine Use of Narrow Band Imaging on Heterotopic Gastric Mucosa of the Proximal Esophagus Detection
Status: COMPLETED
Conditions: Heterotopic Gastric Mucosa of the Proximal Esophagus
Interventions: DEVICE: Esophagus inspection in Narrow Band imaging.|DEVICE: Standard High definition endoscopy.|DEVICE: Esophagus inspection in Narrow Band imaging and increased care.|DEVICE: Standard High definition endoscopy and increased care.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of 2 Low Molecular Weight Heparin as a Thromboprophylaxis Postpartum
Status: COMPLETED
Conditions: Venous Thromboembolic Diseases
Interventions: DRUG: Bemiparin|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Extension Study of Oral Edaravone Administered in Subjects With ALS
Status: TERMINATED
Conditions: ALS
Interventions: DRUG: MT-1186|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Australian Phase 2b Study to Assess Effect of Dose Interval on Spikogen Covid-19 Vaccine
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: Spikogen/Covax-19
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nitric Oxide Gas Inhalation for Severe Acute Respiratory Syndrome in COVID-19.
Status: WITHDRAWN
Conditions: Coronavirus Covid-19 Infection Variant Omicron|SARS (Severe Acute Respiratory Syndrome)
Interventions: DRUG: Nitric Oxide Gas|OTHER: The delivery system will be set up anyway without study gas administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of a Treadmill Walking Test to Discriminate Neurogenic Claudication From Vascular Claudication
Status: COMPLETED
Conditions: Spinal Stenosis Lumbar|Low Back Pain|Peripheral Artery Disease|Claudication
Interventions: DIAGNOSTIC_TEST: Treadmill walking test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial of Polatuzumab Vedotin, Obinutuzumab and Glofitamab as a Peri-CAR-T Cell Treatment Strategy in Large B-cell Lymphoma
Status: RECRUITING
Conditions: Large B-cell Lymphoma
Interventions: DRUG: Glofitamab|DRUG: Polatuzumab vedotin|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Bilirubinometry in Neonates With the BiliCare System Compared to the Invasive TSB Test
Status: COMPLETED
Conditions: We Will Focus on Assessing the Clinical Performance of the BiliCare Device
Interventions: DEVICE: BiliCare
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Short-term Disulfiram Administration to Reverse Latent HIV Infection: a Dose Escalation Study
Status: COMPLETED
Conditions: HIV|Human Immunodeficiency Virus
Interventions: DRUG: Disulfiram
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess the Safety and Tolerability of U3-1565 in Subjects With Advanced Solid Malignant Tumors
Status: COMPLETED
Conditions: Advanced Solid Malignant Tumors|Advanced Ovarian Cancer
Interventions: DRUG: U3-1565
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adrecizumab-LPS Study
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Endotoxin|DRUG: Placebo|DRUG: Adrecizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ARRY-382 in Combination With Pembrolizumab for the Treatment of Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: DRUG: ARRY-382|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Teacher-Child Interaction Training - Universal in Head Start
Status: TERMINATED
Conditions: Child Behavior|Child Development|Child Behavior Problem
Interventions: BEHAVIORAL: Teacher-Child Interaction Training - Universal
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Impact of Probiotic Supplementation on Antibiotic Induced Changes in Gastrointestinal Function and/or Faecal Microbiota Composition
Status: COMPLETED
Conditions: Antibiotic Side Effect
Interventions: DIETARY_SUPPLEMENT: LAB4 + Saccharomyces boulardii|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of SHR8058 on Signs and Symptoms of Dry Eye Disease Associated With Meibomian Gland Dysfunction
Status: COMPLETED
Conditions: Treatment of Dry Eye Disease With Meibomian Gland Dysfunction
Interventions: DRUG: SHR8058 eye drops|DRUG: saline eye drops.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Perioperative Chemotherapy Combined With Tislelizumab and Trastuzumab in the Treatment of GC/EGC
Status: RECRUITING
Conditions: Stomach Cancer
Interventions: DRUG: Tirelizumab|DRUG: Trastuzumab|DRUG: Docetaxel|DRUG: S1|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methylene Blue in Early Septic Shock
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: 0.9% sodium chloride|DRUG: Methylene Blue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Sufentanil and Remifentanil Infusion During General Anaesthesia for Removal of Wisdom Teeth in Ambulatory Surgery
Status: COMPLETED
Conditions: Tooth Extractions
Interventions: DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Reliability of Highly Dynamic 3D Motion Analysis Protocol in Adolescence and Adult Males
Status: ACTIVE_NOT_RECRUITING
Conditions: Femoroacetabular Impingement
Interventions: OTHER: Reliability of 3D motion analysis protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: CAVATAK (CVA21) in Non-muscle Invasive Bladder Cancer (VLA-012 CANON)
Status: COMPLETED
Conditions: Non-muscle Invasive Bladder Cancer
Interventions: BIOLOGICAL: CVA21|DRUG: Mitomycin C
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor Stem Cell Transplant in Treating Young Patients With Myelodysplastic Syndrome, Leukemia, Bone Marrow Failure Syndrome, or Severe Immunodeficiency Disease
Status: COMPLETED
Conditions: Congenital Amegakaryocytic Thrombocytopenia|Leukemia|Myelodysplastic Syndromes|Severe Congenital Neutropenia
Interventions: BIOLOGICAL: anti-thymocyte globulin|BIOLOGICAL: therapeutic allogeneic lymphocytes|DRUG: fludarabine phosphate|DRUG: thiotepa|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: in vitro-treated peripheral blood stem cell transplantation|RADIATION: total-body irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Dulaglutide (LY2189265) in Participants With Type II Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Dulaglutide|DRUG: Placebo|DRUG: Insulin Glargine|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intermittent Oro-esophageal Tube on Feeding Hesitancy in Stroke Patients
Status: NOT_YET_RECRUITING
Conditions: Dysphagia
Interventions: DEVICE: Intermittent Oro-esophageal Tube Feeding|DEVICE: Nasogastric Tube Feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Multimodality US Based on Angio Planewave Ultrasensitive Imaging and Shear Wave Elastography to Evaluate the Malignancy Risk Value of Thyroid Nodules
Status: RECRUITING
Conditions: Multimoda Lultasound|Thyroid Cancer|Microvascular Classification
Interventions: DIAGNOSTIC_TEST: ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Laser Acupuncture Before and After Embryo Transfer Improves IVF Outcomes
Status: COMPLETED
Conditions: Embryo Implantation
Interventions: PROCEDURE: Needle Acupuncture|PROCEDURE: Laser Acupuncture|PROCEDURE: Sham Laser Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Spectroscopy, Perfusion and Diffusion Tensor Imaging in Neuropsychiatric Lupus
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus|Fibromyalgia|Acute Neuropsychiatric Lupus
Interventions: PROCEDURE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: 1. Study to Evaluate the Efficacy/Safety of Bremelanotide in Premenopausal Women With Hypoactive Sexual Desire Disorder
Status: COMPLETED
Conditions: Hypoactive Sexual Desire Disorder
Interventions: DRUG: Bremelanotide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of OMS103HP in Patients Undergoing Anterior Cruciate Ligament (ACL) Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Reconstruction
Interventions: DRUG: OMS103HP|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rapid Assessment of and Prophylaxis for Influenza in Dwellers of Long-term Care Facilities
Status: COMPLETED
Conditions: Influenza, Human|Pneumonia
Interventions: DEVICE: Sofia Fluorescent Immunoassay Analyzer Influenza A+B|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT