pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Monitoring Noninvasively for Infusion and Transfusion Optimization
Status: WITHDRAWN
Conditions: Post Operative Hemorrhage|Transfusion Related Complication|Blood Transfusion Associated Adverse Reactions|Hypovolemia
Interventions: DEVICE: Pulse CO-Oximeter Sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Phase ll Study of HEC585 in Patients With IPF
Status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: HEC585|DRUG: Pirfenidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proof-of-Concept Interventional Study With a Nasal Spray of JT-1 in Patients With Chronic Rhinitis or Chronic Sinusitis
Status: TERMINATED
Conditions: Chronic Rhinitis|Chronic Sinus Congestion
Interventions: DRUG: JT-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Efficacy of Filgotinib and Lanraplenib in Females With Moderately-to-Severely Active Cutaneous Lupus Erythematosus (CLE)
Status: COMPLETED
Conditions: Cutaneous Lupus Erythematosus
Interventions: DRUG: Lanraplenib|DRUG: Filgotinib|DRUG: Lanraplenib placebo|DRUG: Filgotinib placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Clinical Application of Innovatedly Made Transpalatal Arch (TPA) From 3D Reconstructed Model and Conventionally Made TPA
Status: UNKNOWN
Conditions: Transpalatal Arch (TPA)|Oral Health Related Quality of Life (OHRQoL)|Oral Health Impact Profile Short Version 14 (OHIP 14)|Orthodontic Pain|Three Dimensional (3D) Orthodontic Device
Interventions: DEVICE: Conventional Transpalatal Arch (TPA)|DEVICE: Transpalatal Arch (TPA) fabricated from 3D reconstructed model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Peanut and Peanut Butter Consumption on Blood Lipids and Glycemic Control in Adults With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Peanuts and peanut butter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peanut Allergy Oral Immunotherapy Desensitization
Status: COMPLETED
Conditions: Peanut Allergy
Interventions: PROCEDURE: Peanut protein|PROCEDURE: Oat flour|DRUG: Antihistamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Video Games to Track Cognitive Health
Status: UNKNOWN
Conditions: Dementia|Mild Cognitive Impairment|Cognitive Impairment|Cognitive Decline|Cognitive Changes|Acute Changes in Cognition|Acute Head Injury|Concussion|Mild Traumatic Brain Injury
Interventions: OTHER: SLUMS|OTHER: MMSE|OTHER: MoCA|DEVICE: BrainCheck
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Luteal Support in Frozen-Thawed Embryo Transfer Cycles
Status: COMPLETED
Conditions: Implantation; Placenta|Pregnancy Loss|Frozen Embryo|Luteal Support|Luteal Phase Defect|Assisted Reproduction
Interventions: DRUG: Dydrogesterone 10Mg Tablet (duphaston)|DRUG: Progesterone 50Mg/mL Oil|DRUG: Crinone 8% Vaginal Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pilot Clinical Evaluation of Approved Contact Lenses
Status: COMPLETED
Conditions: Vision Disorders
Interventions: DEVICE: Marketed Contact Lens 1|DEVICE: Marketed Contact Lens 2|DEVICE: Marketed Contact Lens 3|DEVICE: Marketed Contact Lens 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EGCG for Hepatocellular Carcinoma Chemoprevention
Status: RECRUITING
Conditions: Cirrhosis, Liver
Interventions: DRUG: Epigallocatechin gallate (EGCG)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Photobiomodulation on Objective, Physiological Measures of Brain Function in Individuals With Post-Concussion Syndrome
Status: COMPLETED
Conditions: Post-Concussive Syndrome, Chronic|Post-Concussion Syndrome|Mild Traumatic Brain Injury
Interventions: DEVICE: BioFlex Dualport System|DEVICE: Sham device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Acetaminophen Alone Versus Combination of Acetaminophen/Ibuprofen After Cesarean Section
Status: NOT_YET_RECRUITING
Conditions: Cesarean Section|Postoperative Pain
Interventions: DRUG: Acetaminophen|DRUG: Acetaminophen/Ibuprofen|DRUG: Acetaminophen|DRUG: Acetaminophen/Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hydrodilatation With Hypertonic Dextrose Solution Injection After Intra-articular Steroid Injection for Frozen Shoulder
Status: NOT_YET_RECRUITING
Conditions: Frozen Shoulder
Interventions: DRUG: Intra-articular corticosteroid injection|DRUG: hydrodilation with 15% hypertonic dextrose|DRUG: hydrodilation with Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Effects of Riociguat in Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction
Status: COMPLETED
Conditions: Hypertension, Pulmonary|Heart Failure With Normal Ejection Fraction
Interventions: DRUG: Riociguat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Analysis of the Lung Inflammatory Response After Thoracic Surgery With Single or Double Lung Ventilation: a Randomized, Pilot, Trial
Status: COMPLETED
Conditions: Thoracic Diseases|Surgery
Interventions: PROCEDURE: two lung ventilation|PROCEDURE: one lung ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prenatal Pilates Assisted Childbirth Preparation Training and Incontinence
Status: COMPLETED
Conditions: Incontinence, Urinary|Training Group, Sensitivity
Interventions: BEHAVIORAL: Prenatal Pilates Assisted Childbirth Preparation Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ocular Tolerability of Voclosporin Ophthalmic Solution Versus Restasis® in Subjects With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Voclosporin Ophthalmic Solution|DRUG: Restasis®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple-dose Pharmacokinetics of Doripenem During Continuous Venovenous Hemodiafiltration and Molecular Adsorbent Recirculating System in ICU Patients and During Hemodialysis in Longterm Hemodialysis Patients.
Status: COMPLETED
Conditions: Infections During Organ Replacement Therapy
Interventions: OTHER: Pharmacokinetic profiling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of 552-02 in Subjects With Dry Mouth Associated With Sjogren's Syndrome
Status: COMPLETED
Conditions: Dry Mouth Associated With Sjogren's Syndrome|Xerostomia
Interventions: DRUG: Placebo|DRUG: 552-02
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The KHENERGYZE Study
Status: COMPLETED
Conditions: Mitochondrial Diseases|Mitochondrial Myopathies|Mitochondrial Encephalomyopathies|MELAS Syndrome|MIDD
Interventions: DRUG: KH176|DRUG: KH176|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Melatonin for Huntington's Disease (HD) Gene Carriers With HD Related Sleep Disturbance - a Pilot Study
Status: COMPLETED
Conditions: Huntington Disease
Interventions: DIETARY_SUPPLEMENT: Melatonin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Biliary Stenting With or Without Photodynamic Therapy in Treating Patients With Locally Advanced, Recurrent, or Metastatic Cholangiocarcinoma or Other Biliary Tract Tumors That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Extrahepatic Bile Duct Cancer|Gallbladder Cancer
Interventions: DRUG: porfimer sodium|PROCEDURE: biliary stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Luspatercept Plus CsA vs CsA for the Treatment of Newly Diagnosed Non-Transfusion-Dependent NSAA
Status: NOT_YET_RECRUITING
Conditions: Aplastic Anemia
Interventions: DRUG: Luspatercept|DRUG: cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotic and Smectite Gel on NAFLD
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease|Fatty Liver|Liver Diseases|Digestive System Diseases|Type2 Diabetes
Interventions: DIETARY_SUPPLEMENT: "Symbiter Forte"|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Comparing Different Modes of Non-invasive Ventilation for the Oral Feeding of Preterm Infants
Status: COMPLETED
Conditions: Feeding Behavior|Chronic Lung Disease
Interventions: DEVICE: Fisher & Paykel heated humidified high flow nasal cannula|DEVICE: InfantFlow/RAM nasal continuous positive airway pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerance and Pharmacokinetics Study of MNTX Tablets
Status: COMPLETED
Conditions: Normal Healthy Volunteers
Interventions: DRUG: Oral methylnaltrexone|DRUG: Oral placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Injection Site Pain Associated With a New Etanercept Formulation in Adults With Rheumatoid Arthritis or Psoriatic Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid; Arthritis, Psoriatic
Interventions: DRUG: Commercial Formulation Etanercept|DRUG: New Formulation Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Collaborative Care for Children's Mental Health Problems
Status: COMPLETED
Conditions: Depression|Anxiety|Attention Deficit Hyperactivity Disorder|Oppositional Defiant Disorder|Parent-Child Relations|Substance Use
Interventions: OTHER: Training in management of children's mental health problems|OTHER: Current collaborative care protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Reduced Intensity Conditioning Using CD3+/CD19+ Depletion for Non Malignant Transplantable Diseases
Status: COMPLETED
Conditions: Bone Marrow Failure Syndromes|Immunodeficiencies|Immune Dysregulation Syndromes
Interventions: DEVICE: CliniMACs device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Avastin (Bevacizumab) With XELOX or FOLFOX in Patients With Metastatic Colorectal Cancer and Disease Progression Under First-line FOLFIRI and Avastin
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: fluorouracil (5FU)|DRUG: leucovorin|DRUG: bevacizumab [Avastin]|DRUG: capecitabine [Xeloda]|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Pertuzumab to Treat Castration-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: rhuMAb 2C4 (pertuzumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FertiScreen: an Online Application to Improve the Quality of Fertility Care
Status: UNKNOWN
Conditions: Unexplained Subfertile Couples With a Good Prognosis.
Interventions: OTHER: FertiScreen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy of Zimberelimab (AB122) in Combination With Domvanalimab (AB154) and Etrumadenant (AB928) in Patients With Previously Treated Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer|Non-small Cell Carcinoma|Non-small Cell Lung Cancer
Interventions: DRUG: Zimberelimab|DRUG: Domvanalimab|DRUG: Etrumadenant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trismus Prevention, Diagnosis and Management: Radiotherapy Planning, Early Detection, and Physical Therapy Intervention
Status: UNKNOWN
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: RADIATION: Masticators sparing techniques|OTHER: electro-acupunture treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Antibiotics for Delirium in Older Adults With No Clear Urinary Tract Infection
Status: RECRUITING
Conditions: Infectious Disease
Interventions: DRUG: Start Antibiotics / Continue Antibiotics for treatment of bacteriuria|OTHER: No Antibiotics for treatment of bacteriuria
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers in Urothelial Cancer Patients Treated With Pembrolizumab
Status: UNKNOWN
Conditions: Transitional Cell Carcinoma of the Bladder|Biomarkers
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clearance of Nasal Staphylococcus Aureus With Triple Antibiotic Ointment
Status: COMPLETED
Conditions: Nasal Carriers of Staphylococcus Aureus
Interventions: DRUG: Neosporin (polymyxin B 5,000units, bacitracin 400 units, neomycin 3.5mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CMR Based Prediction of Ventricular Tachycardia Events in Healed Myocardial Infarction (DEVELOP-VT)
Status: RECRUITING
Conditions: Myocardial Infarction|Myocardial Infarction Old|Arrhythmias, Cardiac|Ventricular Tachycardia|Ventricular Arrythmia|Sudden Cardiac Death|Sudden Cardiac Death Due to Cardiac Arrhythmia
Interventions: DIAGNOSTIC_TEST: Cardiac magnetic resonance imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transcranial Alternating Current Stimulation in Patients With Disorders of Consciousness
Status: RECRUITING
Conditions: Consciousness Disorders
Interventions: DEVICE: real transcranial alternating current stimulation|DEVICE: sham transcranial alternating current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Evaluation of an Interface for the Treatment of Obstructive Sleep Apnea (OSA)
Status: COMPLETED
Conditions: Sleep Disordered Breathing|Obstructive Sleep Apnea
Interventions: DEVICE: F&P Interface
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Sickle Cell Caregiver Collaboration for Child Development (SCCCD) Intervention
Status: NOT_YET_RECRUITING
Conditions: Sickle Cell Disease
Interventions: BEHAVIORAL: Sickle Cell Collaboration for Child Development
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Post-LASIK Flap Thickness of the FS200 Femtosecond Laser Flap
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: FS200 Femtosecond Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Resilience Among Adolescents and Young Adults With Sickle Cell Disease
Status: NOT_YET_RECRUITING
Conditions: Sickle Cell Disease
Interventions: BEHAVIORAL: Collaborative Care Model|BEHAVIORAL: Promoting Resilience in Stress Management
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: to Evaluate Efficacy and Safety of HLX10 in Combination With Chemotherapy Versus Placebo in Combination With Chemotherapy as Neoadjuvant Therapy and HLX10 Versus Placebo as Adjuvant Therapy in Patients With Triple Negative Breast Cancer (TNBC)
Status: NOT_YET_RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: HLX10|DRUG: nab-paclitaxel, carboplatin, doxorubicin or epirubicin and cyclophosphamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Pembrolizumab and Lenvatinib in Resectable Hepatocellular Carcinoma (HCC)
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Pembrolizumab|DRUG: Lenvatinib|DRUG: Pembrolizumab and Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Outcome of Very Preterm Infants Using Collaborative Quality Improvement
Status: WITHDRAWN
Conditions: Morbidity;Newborn|Morality
Interventions: BEHAVIORAL: Evidence-based collaborative quality improvement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Impact of Addiction Management Model on Digital Addiction and Psychological Resilience in Second School Students
Status: RECRUITING
Conditions: Technology Addiction, Psychological Resilience, Risky Technology Use in Adolescent
Interventions: BEHAVIORAL: digital addiction management model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Gemcitabine or Gemcitabine Plus Docetaxel After Cisplatin, Etoposide and Radiation in Non Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: gemcitabine|DRUG: docetaxel|DRUG: cisplatin|DRUG: etoposide|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Treatment of Schizophrenia With Paliperidone Palmitate in Rwandan Healthcare Settings
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Risperidone 3 mg|DRUG: Paliperidone Palmitate 50 mg eq.|DRUG: Paliperidone Palmitate 75 mg eq.|DRUG: Paliperidone Palmitate 100 mg eq.|DRUG: Paliperidone Palmitate 150 mg eq.|DRUG: Paliperidone Palmitate 175 mg eq.|DRUG: Paliperidone Palmitate 263 mg eq.|DRUG: Paliperidone Palmitate 350 mg eq.|DRUG: Paliperidone Palmitate 525 mg eq.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study to Evaluate the Effect of an Investigational Product on Weight Loss and Body Composition
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: IHBG-10|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Safety and Benefit of Natalizumab (Tysabri®) At-home Infusion vs At-hospital Infusion in Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis (MS)
Interventions: OTHER: At-home natalizumab treated MS patient
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized, Double-Blind, Three-Arm, Phase 3b Study Comparing the Safety and Efficacy of Interferon Gamma-1b With Azathioprine, and Azathioprine Alone in Patients With IPF Receiving Prednisone
Status: TERMINATED
Conditions: Lung Disease|Pulmonary Fibrosis
Interventions: DRUG: interferon-gamma 1b|DRUG: azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Incorporating Multidimensional Psychosocial Interventions Improves the Well-being of Individuals With Epilepsy
Status: UNKNOWN
Conditions: Epilepsy|Seizure Disorder
Interventions: BEHAVIORAL: Medication Adherence|BEHAVIORAL: Seizure Documentation|BEHAVIORAL: Memory Improvement|BEHAVIORAL: Stress Management
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: B Vitamin Supplementation to Chiropractic Management of Chronic LBP: Pilot Clinical Trial (VCLBP)
Status: NOT_YET_RECRUITING
Conditions: Recurrent Low Back Pain
Interventions: PROCEDURE: Spinal Manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tulsi (Ocimum Sanctum) on Biochemical Parameters in Young Overweight and Obese Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Tulsi(Ocimum sanctum Linn.) capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Multidisciplinary Interventions in Elderly Asthma Patients With Risk of Acute Exacerbation
Status: UNKNOWN
Conditions: Asthma|Aged
Interventions: DIETARY_SUPPLEMENT: Magnesium|BEHAVIORAL: Education for asthma action plan|BEHAVIORAL: hot-lines for acute exacerbation of asthma|BEHAVIORAL: Inhaler technique training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Examing The Effect Of Omeprazole On Safety, Tolerability And How The Body Processes An Experimental Drug
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: CP-945,598|DRUG: CP-945,598
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Limb Ischaemia (ALI) Management With 'Indigo' Mechanical Aspiration System
Status: UNKNOWN
Conditions: Lower Limb Ischemia
Interventions: DEVICE: 'Indigo' Mechanical thrombectomy system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab and Ipilimumab Treatment in Prostate Cancer With an Immunogenic Signature
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Nivolumab & Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Innervation of Human Cricopharyngeal Muscle By Recurrent Laryngeal and External Branch of Superior Laryngeal Nerve
Status: COMPLETED
Conditions: Larynx
Interventions: DEVICE: The NIM 3.0 Nerve Monitoring System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Timing of Withdrawal of the Laryngeal Mask Airway (LMA) in Children
Status: COMPLETED
Conditions: Laryngeal Mask Airway Removal|Respiratory Complication
Interventions: OTHER: LMA removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Predictive Impact of MMP2 and MMP9 Levels for Patients With Metastatic Kidney Cancer Treated With Anti-angiogenic Agents
Status: UNKNOWN
Conditions: Kidney Cancer
Interventions: PROCEDURE: Blood and tumor samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Physiotherapeutic Scoliosis Specific Exercises As Treatment for Adult Degenerative Scoliosis
Status: WITHDRAWN
Conditions: Degenerative Scoliosis
Interventions: BEHAVIORAL: Physiotherapeutic Scoliosis Specific Exercises (PSSE)|BEHAVIORAL: Conventional Physical Therapy (PT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preventing Pressure Injuries in Patients Undergoing Lumbar Spine Surgery
Status: COMPLETED
Conditions: Pressure Injury
Interventions: DEVICE: cotton roll-coated viscoelastic polymer pads|DEVICE: viscoelastic polymer pads
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Healthy Immigrant Community: Mobilizing the Power of Social Networks
Status: ACTIVE_NOT_RECRUITING
Conditions: Weight Loss
Interventions: BEHAVIORAL: Community-based mentoring and education sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neoadjuvant Toripalimab in Combination With Gemcitabine Therapy in Cisplatin Ineligible Local Advanved Bladder Cancer
Status: UNKNOWN
Conditions: Urothelial Carcinoma|Bladder Cancer
Interventions: DRUG: Toripalimab|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Trial for the Diagnosis and Treatment of Intracranial Germ Cell Tumors
Status: UNKNOWN
Conditions: Intracranial Germ Cell Tumors
Interventions: RADIATION: craniospinal irradiation|DRUG: Carboplatin, Etoposide, Ifosfamide|RADIATION: ventricular irradiation|DRUG: Cisplatin, etoposide, Ifosfamide (standard)|DRUG: Cisplatin, Etoposide, Ifosfamide (high dose)|RADIATION: focal irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Premedication Simethione Improves Visibility During Bowel Cleansing for Colonoscopy
Status: COMPLETED
Conditions: Bowel Preparation Scale|the Amount of Air Bubble|Adenoma Detection Rate
Interventions: DRUG: 2L PEG|DRUG: 2L PEG+simethicone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: S0220: Chemoradiotherapy Followed By Surgery and Docetaxel in Treating Patients With Pancoast Tumors
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: docetaxel|DRUG: etoposide|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of an Anticholinergic Agent for Treatment of Primary Axillary Hyperhidrosis
Status: COMPLETED
Conditions: Hyperhidrosis
Interventions: DRUG: WL8713, 6 mg|DRUG: WL8713, 12 mg|DRUG: WL8713, 18 mg|DRUG: WL8713, 24 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Pharmacokinetics, Efficacy, and Safety of Brivaracetam in Newborns With Repeated Electroencephalographic Seizures
Status: TERMINATED
Conditions: Electroencephalographic Neonatal Seizures
Interventions: DRUG: Brivaracetam (BRV) intravenous (iv)|DRUG: Brivaracetam (BRV) oral
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genomically Guided Radiation Dose Personalization in Locally Advanced NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Nonsmall Cell Lung Cancer|Nonsmall Cell Lung Cancer, Stage II|Nonsmall Cell Lung Cancer Stage III|Unresectable Non-Small Cell Lung Carcinoma
Interventions: RADIATION: Genomically Guided Radiation Therapy (RT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Pharmacokinetic, Safety and Tolerability of Tiotropium in Outpatients With Renal Impairment in Comparison to Healthy Subjects
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: DRUG: Tiotropium, solution ampoules
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regimen Optimization Study
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: Thymoglobulin|DRUG: Belatacept|DRUG: mycophenolate mofetil(MMF)|DRUG: Corticosteroids|DRUG: Everolimus(EVL)|DRUG: Tacrolimus(TAC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Norwegian Trial of Physical Exercise After Myocardial Infarction
Status: ENROLLING_BY_INVITATION
Conditions: Myocardial Infarction
Interventions: BEHAVIORAL: Physical exercise|BEHAVIORAL: Standard care|BEHAVIORAL: Observation group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The INCREASE Study - Delaying the Onset of Alzheimer's Symptomatic Expression
Status: COMPLETED
Conditions: Alzheimer's Disease|Dementia
Interventions: OTHER: Placebo|OTHER: Medication Therapy Management (MTM)|DRUG: Scopolamine patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Sub-study to LMF237A2302 to Assess the Effect of 24 Weeks Treatment With Initial Combination of Vildagliptin Plus Metformin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: vildagliptin + metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Variation of Echocardiographic Parameters After Red Blood Cell Transfusion in Emergency Department Anemic Patients
Status: RECRUITING
Conditions: Anemia|Age Problem|Ultrasonography
Interventions: DIAGNOSTIC_TEST: transthoracic echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pharmacokinetics Study of Aleglitazar in Combination With Digoxin in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: aleglitazar|DRUG: digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Microsurgical vs Macro Surgical Approach for Grade II Gingival Recessions Employing Laterally Repositioned Flap
Status: COMPLETED
Conditions: Gingival Recession, Localized
Interventions: PROCEDURE: root coverage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Patiromer in Heart Failure Patients
Status: COMPLETED
Conditions: Hyperkalemia|Heart Failure
Interventions: DRUG: patiromer|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Immunoradiotherapy With Evorpacept and Pembrolizumab in HPVOPC (Human Papilloma Virus Oropharynx Cancer)
Status: RECRUITING
Conditions: Oropharynx Cancer
Interventions: DRUG: Evorpacept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Compare the Efficacy of I.V 200 mg Iron Sucrose and 500 mg Iron Sucrose to Treat Anemia in Pregnancy
Status: WITHDRAWN
Conditions: Pregnancy
Interventions: DIETARY_SUPPLEMENT: Iron sucrose 200 mg|DIETARY_SUPPLEMENT: Iron sucrose 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of Abemaciclib to Olaparib for Women With Recurrent Ovarian Cancer
Status: RECRUITING
Conditions: Recurrent Ovarian High Grade Serous Adenocarcinoma|Recurrent Platinum-Resistant Ovarian Carcinoma
Interventions: DRUG: Abemaciclib|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Voice Analysis Using the LPC (Linear Predictive Coding)Method for the Prediction of Aspiration
Status: WITHDRAWN
Conditions: Deglutition Disorder
Interventions: DEVICE: VFSS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Clopidogrel/Aspirin Interaction Study
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Clopidogrel|DRUG: Clopidogrel|DRUG: Aspirin|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Comparison of Endodontically Treated Teeth Restored With Fiber Posts or Cast Metal Posts
Status: UNKNOWN
Conditions: Post and Core Failure
Interventions: PROCEDURE: fiber post and resin core - self-adhesive cement|PROCEDURE: cast post and core|PROCEDURE: fiber post luted with conventional resin cement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-Portal Alone Versus Intra- and Extra-Portal Transplantation of Pancreatic Islets After Total Pancreatectomy for Chronic Pancreatitis
Status: RECRUITING
Conditions: Chronic Pancreatitis|Diabetes Mellitus|Islet Cell Transplantation
Interventions: PROCEDURE: Intrahepatic islets and islets in the omental pouch|PROCEDURE: Intrahepatic islets alone|OTHER: Normal Volunteers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability and Pharmacokinetics of Mango
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DIETARY_SUPPLEMENT: Active Comparator 1|DIETARY_SUPPLEMENT: Active Comparator 2|DIETARY_SUPPLEMENT: Control Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Dexametasone Versus Dexametasone Plus Dexmedetomidine in Nerve Blocks
Status: COMPLETED
Conditions: Analgesia|Pain, Acute|Upper Extremity Injury
Interventions: DRUG: Dexamethasone|DRUG: Dexmedetomidine-Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Xla1 Christensenella Minuta, Phase I, Randomized, Partially Placebo-controlled Double-blind Protocol, Evaluating Safety, Tolerability and Impact on the Gut Microbiota in Healthy Volunteers, Overweight and Obese Adults
Status: COMPLETED
Conditions: Obesity|Metabolic Disease
Interventions: DRUG: Xla1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Therapy for Treatment-resistant Auditory Hallucinations in Schizophrenia
Status: COMPLETED
Conditions: Auditory Hallucination, Verbal|Treatment-resistant Schizophrenia
Interventions: BEHAVIORAL: Avatar therapy|OTHER: Treatment-as-usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Study With Famotidine, Atazanavir, and Atazanavir/Ritonavir/Tenofovir
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Atazanavir+Ritonavir+Tenofovir|DRUG: Atazanavir+Ritonavir+Tenofovir+Famotidine|DRUG: Atazanavir+Ritonavir+Tenofovir+Famotidine|DRUG: Atazanavir+Ritonavir+Tenofovir+Famotidine|DRUG: Atazanavir+Ritonavir+Tenofovir+Famotidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A Comparative Assessment of Orthodontic Treatment Outcomes Using the Quantitative Light-Induced Fluorescence Method
Status: COMPLETED
Conditions: White Spot Lesion of Tooth|Orthodontic Malocclusion
Interventions: DEVICE: Quantitative Light-Induced Fluorescence|PROCEDURE: Direct bonding|PROCEDURE: Indirect bonding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Robotic Versus Manually-Assisted Locomotor Training for Individuals With Incomplete Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: PROCEDURE: Manually Assisted Locomotor Training|OTHER: Robotic Assisted Locomotor Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization of Positive End Expiratory Pressure by Use of Pulmonary Ultrasound for Patients With Blunt Chest Trauma Treated by Non-Invasive Ventilation (Opti-PEP).
Status: RECRUITING
Conditions: Thoracic Injuries|Non-invasive Ventilation
Interventions: OTHER: Lung Ultrasound for PEEP setting|PROCEDURE: Non invasive ventilation session|BIOLOGICAL: Arterial blood gas|OTHER: Interview on pain and comfort
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Telmisartan Pilot Study on Treatment Resistant Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia|Schizo Affective Disorder|Treatment-resistant Schizophrenia
Interventions: DRUG: Telmisartan Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phacoemulsification and 25 Gauge (25G) Vitrectomy Versus Phacoemulsification Only in Idiopathic Epiretinal Membranes
Status: COMPLETED
Conditions: Epiretinal Membrane
Interventions: PROCEDURE: 25-G vitrectomy and phacoemulsification|PROCEDURE: phacoemulsification (cataract surgery)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxypropylmethylcellulose 0.3% and Sodium Hyaluronate 0.18% for Ocular Surface Disease in Glaucoma
Status: UNKNOWN
Conditions: Ocular Surface Disease|Glaucoma
Interventions: DRUG: hydroxypropylmethylcellulose|DRUG: sodium hyaluronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of COVID-19 and Influenza Combination Vaccine
Status: COMPLETED
Conditions: COVID-19|Influenza
Interventions: DRUG: qNIV Vaccine with Matrix-M Adjuvant|DRUG: Influenza Vaccine|DRUG: CIC Vaccine with Matrix-M Adjuvant|OTHER: Placebo Comparator|DRUG: SARS-CoV-2 rS Vaccine with Matrix-M Adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Performance of Newly Developed 1-piece Ostomy Product Compared With SenSura
Status: COMPLETED
Conditions: Ileostomy - Stoma
Interventions: DEVICE: Test product|DEVICE: SenSura
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Early Renal Involvement on the Development of Severe In-hospital Renal Failure
Status: UNKNOWN
Conditions: Kidney Failure, Acute|Renal Insufficiency, Acute|Kidney Failure|Renal Insufficiency
Interventions: OTHER: Early Renal Involvement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Efficacy, Safety and Pharmacokinetics of Debio 4326 in Pediatric Participants Receiving Gonadotropin-Releasing Hormone Agonist Therapy for Central Precocious Puberty
Status: RECRUITING
Conditions: Central Precocious Puberty
Interventions: DRUG: Debio 4326
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estrogen Replacement to Reduce Risk of Neurologic Injury After Coronary Artery Bypass Graft Surgery
Status: TERMINATED
Conditions: Coronary Disease|Cardiovascular Diseases|Heart Diseases|Neurologic Manifestations
Interventions: DRUG: Estrogen Replacement Therapy|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Neuromodulation in Patients With Hamstring Shortening
Status: COMPLETED
Conditions: Hamstring Contractures
Interventions: OTHER: Ultrasound-guided Percutaneous Neuromodulation|OTHER: Ultrasound-guided Percutaneous Needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Function Magnetic Resonance Imaging to Assess Two Therapeutic Strategies in Multiple Sclerosis (NeuroRehEM).
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: N-back Cognitive Training|BEHAVIORAL: Virtual Reality Motor and Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Fruit Extracts on Glycaemia: The GLU-FRU Study
Status: COMPLETED
Conditions: Postprandial Hyperglycemia
Interventions: DIETARY_SUPPLEMENT: Polyphenols
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CyberKnife for Unresectable Renal Tumors
Status: COMPLETED
Conditions: Renal Cancer
Interventions: RADIATION: Stereotactic radiation|DEVICE: CyberKnife Robotic Radiosurgery System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Intragastric Quinine, Alone or Combined With L-isoleucine, on Postprandial Glycaemic Control
Status: RECRUITING
Conditions: Healthy
Interventions: OTHER: Quinine|OTHER: L-isoleucine|OTHER: Combination of quinine and L-isoleucine|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of 3 Years of Exercise in Patients With Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: BEHAVIORAL: Interval exercise|BEHAVIORAL: Moderate exercise|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Erector Spinae Block -Dexmedetomidine
Status: RECRUITING
Conditions: Postoperative Acute Pain|Opioid Consumption
Interventions: DRUG: esp Dexmedetomidine (dekstomid)|DRUG: esp remifentanyl (ultiva)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Perioperative Coagulation Management in Cardiac Surgery.
Status: TERMINATED
Conditions: Cardiac Surgery|Bleeding
Interventions: DEVICE: Rotation thromboelastometry (ROTEM)|PROCEDURE: Standard coagulation managment procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Combined Exercise, Heat, and Quercetin Supplementation on Whole Body Stress Response
Status: COMPLETED
Conditions: Heat Acclimation and Thermotolerance
Interventions: DIETARY_SUPPLEMENT: Quercetin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE