pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Trial Exploring Afatinib (BIBW 2992) + Paclitaxel (Part A), Afatinib + Paclitaxel + Bevacizumab (Part B), Afatinib + Carboplatin (Part C) and Afatinib+ Paclitaxel +Carboplatin(Part D) in Patients With Advanced Solid Tumours
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: BIBW 2992|DRUG: Paclitaxel|DRUG: BIBW2992|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Bevacizumab|DRUG: BIBW 2992|DRUG: BIBW 2992
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial Comparing a Ventilatory Strategy To Prevent Atelectasis Versus a Lateral Decubitus Strategy During Robotic Bronchoscopy (VESPA vs. LADS Trial)
Status: RECRUITING
Conditions: Pulmonary|Lung
Interventions: PROCEDURE: Ventilatory Strategy To Prevent Atelectasis|PROCEDURE: Lateral Decubitus Strategy (LADS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Role of Sugammadex in Posotoperative Urinary Retention in Patients Undergoing Pelvic Floor Reconstructive Procedures
Status: RECRUITING
Conditions: Postoperative Urinary Retention
Interventions: DRUG: Sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of Single Oral Doses of Dabigatran Etexilate With or Without Oral Administration of Verapamil in Two Different Dosages in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: dabigatran|DRUG: Verapamil|DRUG: Verapamil ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Surfactant Protein D (rfhSP-D) to Prevent Neonatal Chronic Lung Disease
Status: NOT_YET_RECRUITING
Conditions: Chronic Lung Disease of Prematurity|Respiratory Distress Syndrome in Premature Infant|Bronchopulmonary Dysplasia
Interventions: DRUG: Recombinant fragment of human surfactant protein D (rfhSP-D)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Trial in Acute Promyelocytic Leukemia Patients
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: arsenic trioxide|DRUG: idarubicin|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: all-trans retinoic acid|DRUG: all-trans retinoic acid (ATRA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Trial Evaluating Safety, Efficacy, and Pharmacokinetics of Multiple Subcutaneous Doses of TransCon CNP Administered Once Weekly in Children With Achondroplasia
Status: ACTIVE_NOT_RECRUITING
Conditions: Achondroplasia
Interventions: DRUG: TransCon CNP|DRUG: Placebo for TransCon CNP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
Status: RECRUITING
Conditions: Solid Tumors|Malignant Pleural Mesothelioma|Gastric Adenocarcinoma|Colorectal Adenocarcinoma|Sarcoma|Pancreatic Adenocarcinoma|Ewing Sarcoma|Chondrosarcoma|GIST|SDH-deficient Solid Tumors
Interventions: DRUG: INBRX-109|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Pemetrexed|DRUG: 5-fluorouracil|DRUG: Irinotecan|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About the Relationship Between Hepatic Impairment and Myelosuppression (Decreased Bone Marrow Function) in Breast Cancer Patients Treated With the Study Medicine Palbociclib (Pal-bow-sai-klib)
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Efficacy and Safety of Bimekizumab in Chinese Adult Study Participants With Moderate to Severe Plaque Psoriasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Plaque Psoriasis|Moderate to Severe Chronic Plaque Psoriasis
Interventions: OTHER: Placebo|DRUG: Bimekizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Disitamab Vedotin and Anlotinib in Patients With HR-Negative, HER2-Low-Expressing Metastatic Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Disitamab Vedotin+Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transmission Electron Microscopy Images for Platelet Ultrastructural Criteria Before and After the Onset of an Antiplatelet Agent
Status: NOT_YET_RECRUITING
Conditions: Ischemic Stroke
Interventions: BIOLOGICAL: Blood collection before antiplatelet treatment|BIOLOGICAL: Blood collection after antiplatelet treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Psyllium Fibre on LDL-C, Non-HDL-C, and Apolioprotein-B: A Systematic Review and Meta-analysis
Status: UNKNOWN
Conditions: Hypercholesterolemia|Cardiovascular Risk Factor
Interventions: DIETARY_SUPPLEMENT: Psyllium Fibre
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Imaging Staging and Response Prediction in Metastatic Hormono-Sensitive Prostate Cancer Patients Receiving Enzalutamide
Status: COMPLETED
Conditions: Prostate Cancer Metastatic
Interventions: DRUG: Enzalutamide|PROCEDURE: 11C or 18F-Choline PET/CT|PROCEDURE: Whole body MRI|PROCEDURE: Bone scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Treatment for Pilonidal Disease : Safety of Use, Efficacy and Patient Satisfaction at 6 Months
Status: ACTIVE_NOT_RECRUITING
Conditions: Infected Pilonidal Sinus
Interventions: DEVICE: radiofrequency treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Smoking Cessation in the Community Via QTW 2014
Status: COMPLETED
Conditions: Smoking Cessation Intervention
Interventions: BEHAVIORAL: Quit immediately (QI) / cut down to quit (CDTQ)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Corrected Carotid Flow Time and the Inferior Vena Cava Collapsibility Index in Predicting Post-spinal Anesthesia Hypotension in Geriatric Patients
Status: RECRUITING
Conditions: Anesthesia
Interventions: PROCEDURE: Corrected carotid flow time, IVC diameter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Disitamab Vedotin Plus Cadonilimab in Patients With HER2 Mutant Advanced or Metastatic Bile Duct Adenocarcinoma
Status: RECRUITING
Conditions: Bile Duct Adenocarcinoma Non-Resectable|HER2 Gene Mutation
Interventions: DRUG: Disitamab Vedotin Plus Cadonilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine vs Ketofol on Delirium in Children Undergoing Congenital Inguinal Hernia Repair
Status: RECRUITING
Conditions: Dexmedetomidine|Ketofol|Delirium|Hernia
Interventions: DRUG: Dexmedetomedine|DRUG: Ketofol|DRUG: isotonic saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SORT OUT X - Combo Stent Versus ORSIRO Stent
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Heart Disease|Angina Pectoris|Myocardial Infarction
Interventions: DEVICE: COMBO|DEVICE: ORSIRO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study With Clevudine Monotherapy or Adefovir and Clevudine Combination in Patients With Chronic Hepatitis B
Status: TERMINATED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Clevudine, Adefovir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sapanisertib and Metformin in Treating Patients With Advanced or Metastatic Relapsed or Refractory Cancers
Status: COMPLETED
Conditions: Advanced Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm|Recurrent Malignant Solid Neoplasm|Refractory Neoplasm
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Metformin|OTHER: Pharmacological Study|DRUG: Sapanisertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Botulinum Toxin A Injections on Ankle Dorsiflexion Following Internal Fixation of Tibial Pilon Fractures
Status: TERMINATED
Conditions: Equinus Contracture
Interventions: DRUG: Botulinum toxin type A|DRUG: sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Treatments for Opioids and Other Substance Use Disorders in Primary Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Drug Use Disorders|Illicit Drug Use|Alcohol-Related Disorders|Opioid Use Disorder
Interventions: BEHAVIORAL: Standard implementation|BEHAVIORAL: Health Coaching|BEHAVIORAL: Practice Facilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Chronic Cannabis Users: A Model for Negative Symptoms in Schizophrenia
Status: UNKNOWN
Conditions: Chronic Cannabis Users|Healthy Subjects
Interventions: PROCEDURE: Magnetoencephalograph (MEG)|BEHAVIORAL: Cambridge Neuropsychological Test Automated Battery (CANTAB).|BEHAVIORAL: Experimental: Scale for the Assessment of Negative Symptoms (SANS) and the Positive and Negative Syndrome Scale (PANSS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Initial Ozurdex (Dexamethasone Implant) to Avastin (Bevacizumab) for Treatment of Macular Edema Caused by Central Retinal Vein Occlusion (CRVO)
Status: COMPLETED
Conditions: Macular Edema|Central Retinal Vein Occlusion
Interventions: DRUG: Ozurdex|DRUG: Avastin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Multiple Subcutaneous Injections of ABT-122 in Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: ABT-122|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Acute Effects of Meals Rich in Saturated or Unsaturated Fatty Acids on Postprandial Lipaemia in Healthy Men
Status: COMPLETED
Conditions: Cardiovascular Risk Factor
Interventions: DIETARY_SUPPLEMENT: Coconut oil|DIETARY_SUPPLEMENT: Butter|DIETARY_SUPPLEMENT: Vegetable oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Text and Talk: A Multi-level Intervention to Increase Provider HPV Vaccine Recommendation Effectiveness
Status: ACTIVE_NOT_RECRUITING
Conditions: HPV
Interventions: BEHAVIORAL: Brief Provider Training - Bundled Approach|BEHAVIORAL: Brief Provider Training - Benefits Approach|BEHAVIORAL: Parent Interactive Text Message - Bundled Approach|BEHAVIORAL: Parent Interactive Text Message - Benefits Approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy, Safety, and PK of LX9211 in Patients With Diabetic Peripheral Neuropathic Pain
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathy|Diabetes
Interventions: DRUG: LX9211 low dose|DRUG: LX9211 high dose|DRUG: LX9211 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of ZR2 Versus R-miniCHOP in the Treatment of Unfit or Frail de Novo Diffuse Large B-cell Lymphoma Patients Aged Older Than or Equal to 70 Years
Status: RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: six courses of zanubrutinib, rituximab and lenalidomide|DRUG: six courses of rituximab combined with low-dose CHOP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Suture Materials: an Evaluation
Status: COMPLETED
Conditions: Suture Materials
Interventions: DEVICE: Silk 4.0|DEVICE: PG 910 4.0|DEVICE: PP 4.0|DEVICE: Silk 5.0|DEVICE: PG910 5.0|DEVICE: PP 5.0|DEVICE: APG 5.0|DEVICE: ePTFE 5.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reusing Needles for Subcutaneous Insulin Injection in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: Does not reuse the syringe for insulin application|DEVICE: Uses the syringe for insulin delivery five times
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Investigation of Clofarabine in Acute Leukemias
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Acute Lymphocytic Leukemia|Chronic Myelogenous Leukemia
Interventions: DRUG: clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Micro-Patterned Foley Catheter to Reduce Catheter-Associated Urinary Tract Infection
Status: TERMINATED
Conditions: Urinary Tract Infection
Interventions: BIOLOGICAL: Urine Culture|DEVICE: Foley Catheter Tip Culture|DEVICE: Scanning Electron Microscopy|PROCEDURE: Device Specific Adverse Event Assessment|PROCEDURE: Foley Catheter Insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Peginterferon Beta-1a (CinnaGen) in Participants With Relapsing Remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis (RRMS)
Interventions: DRUG: Pegylated interferon beta-1a|DRUG: Interferon Beta-1A Prefilled Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of SAR113945 Following Intra-articular Administration in Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: placebo|DRUG: SAR113945
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quality of Life in Female Breast Cancer Survivors and Their Spouse, Partner, or Acquaintance
Status: COMPLETED
Conditions: Breast Cancer|Cancer Survivor|Cognitive/Functional Effects|Psychosocial Effects of Cancer and Its Treatment|Sexuality and Reproductive Issues|Spiritual Concerns
Interventions: PROCEDURE: cognitive assessment|PROCEDURE: psychosocial assessment and care|PROCEDURE: quality-of-life assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy Study of Pemetrexed + Platinum Chemotherapy + Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-7902-006/E7080-G000-315/LEAP-006)-China Extension Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Nonsquamous Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Pemetrexed|DRUG: Lenvatinib|DRUG: Placebo matching lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Supplement for Pregnant and Lactating Mothers
Status: COMPLETED
Conditions: Diarrhea|Acute Respiratory Infection
Interventions: DIETARY_SUPPLEMENT: milk supplement 1|DIETARY_SUPPLEMENT: milk supplement 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Photodynamic Therapy and LASER Disinfection in Periodontal Therapy for Treatment of Periodontitis
Status: RECRUITING
Conditions: Periodontitis
Interventions: DEVICE: LASER disinfection|DEVICE: Photodynamic therapy|PROCEDURE: Root surface debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maternal Voice and Quantitative EEG (qEEG)
Status: ACTIVE_NOT_RECRUITING
Conditions: Prematurity|Development Delay|Premature Birth
Interventions: BEHAVIORAL: Recorded Maternal Voice|BEHAVIORAL: Placebo Recording
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pronase Granules in Gastric Cleaning
Status: UNKNOWN
Conditions: Gastric Disease|Capsule Endoscopy
Interventions: DRUG: Deyou; Beijing Tide Pharmaceutical Co, China, containing 20,000 iu pronase granules combined with 1 g NaHCO3 to maintain the intragastric PH at 6-8
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Ventricular Repolarization in Patients With Premature Ovarian Insufficiency (QT-IOP)
Status: RECRUITING
Conditions: Premature Ovarian Insufficiency
Interventions: DRUG: Hormone replacement therapy:effect on ventricular repolarization|DIAGNOSTIC_TEST: ECG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of LCZ696 200 mg + Amlodipine 5 mg in Comparison With Amlodipine 5 mg in Hypertensive Patients Not Responding to Amlodipine
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: LCZ696|DRUG: Amlodipine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-T-Lymphocyte Globulin (ATG) in Renal Transplantation of Kidneys With a Non-Heart-Beating (NHB) Donor
Status: UNKNOWN
Conditions: Renal Transplant Patients|Recipients of a Kidney From a Non-Heart-Beating Donor
Interventions: DRUG: ATG Fresenius
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-market Registry of the AMDS for the Treatment of Acute DeBakey Type I Dissection
Status: RECRUITING
Conditions: Aortic Dissection|Acute DeBakey I Dissection|Acute Type A Dissection|Intramural Hematoma
Interventions: DEVICE: Ascyrus Medical Dissection Stent (AMDS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Impact of Cranberries On the Microbiome and the Brain in Healthy Ageing sTudy (COMBAT)
Status: COMPLETED
Conditions: Aging|Cognitive Decline
Interventions: DIETARY_SUPPLEMENT: Freeze-Dried Cranberry Powder|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Recombinant Human Growth Hormone Injection（JINTOPIN AQ）for Short Children With Small for SGA
Status: COMPLETED
Conditions: Small for Gestational Age Infant
Interventions: BIOLOGICAL: Somatropin Injection low dose group|BIOLOGICAL: Somatropin Injection high dose group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of GMA301 in Subjects With Pulmonary Arterial Hypertension
Status: UNKNOWN
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Q4W GMA301 IV injections (300 mg)|DRUG: Q4W GMA301 IV injections (600 mg)|DRUG: Q4W GMA301 IV injections (1000 mg)|DRUG: Q4W GMA301 IV injections (1800 mg)|OTHER: Q4W placebo IV injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pressure Support Ventilation During Laparoscopic and Abdominal Robotic Surgery.
Status: COMPLETED
Conditions: Ventilator-Induced Lung Injury
Interventions: PROCEDURE: Mandatory ventilation|PROCEDURE: pressure support ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Paravertebral Morphine Versus Dexmedetomidine on Acute and Chronic Postmastectomy Pain
Status: UNKNOWN
Conditions: Acute Pain|Chronic Pain
Interventions: DRUG: bupivicaine|DRUG: morphine|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects on Microcirculation of IgGAM in Severe Septic/Septic Shock Patients.
Status: COMPLETED
Conditions: Severe Sepsis|Septic Shock
Interventions: DRUG: Pentaglobin®|DRUG: Physiologic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility of the Use of Natural Killer Cells in Patients With Chronic Myeloid Leukemia
Status: UNKNOWN
Conditions: Chronic Myeloid Leukemia
Interventions: BIOLOGICAL: Chronic Myeloid Leukemia + NK cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block for Postoperative Pain in Percutaneous Nephrolithotomy Patients: a Retrospective Study
Status: COMPLETED
Conditions: Percutaneous Nephrolithotomy
Interventions: PROCEDURE: Erector Spinae Plane block ( Group I)|PROCEDURE: non- blocked Group (GROUP II)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Afatinib (BIBW 2992) QTcF Trial in Patients With Relapsed or Refractory Solid Tumours
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: BIBW 2992
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment
Status: COMPLETED
Conditions: Opioid Use Disorder
Interventions: DRUG: Extended-Release Naltrexone|DRUG: Buprenorphine-Naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Vitamin C, Vitamin E and Their Combination to Treat Restless Legs Syndrome in Hemodialysis Patients
Status: COMPLETED
Conditions: Restless Legs Syndrome|Kidney Failure, Chronic
Interventions: DRUG: Vitamin C & Vitamin E|DRUG: Vitamin C|DRUG: Vitamin E|DRUG: Vitamin C Placebo & Vitamin E Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SOS Versus Awake Fiberoptic Intubation
Status: COMPLETED
Conditions: Cervical Spine Instability
Interventions: DEVICE: Shikani optical stylet|DEVICE: Flexible fiberoptic bronchoscope for
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Efficacies of Median Nerve Hydrodissection With Dexamethasone and Dextrose in Carpal Tunnel Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Carpal Tunnel Syndrome|Median Nerve Entrapment|Entrapment Neuropathy
Interventions: PROCEDURE: Ultrasound-guided median nerve hydrodissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy Plus QS21 in Treating Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: MUC-2-Globo H-KLH conjugate vaccine|BIOLOGICAL: QS21
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastric Modulator (TANTALUS® System) Versus Insulin Treatment in Obese Type 2 Diabetic Patients - a Randomized Control Trial
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DEVICE: Tantalus|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of Particulate Versus Nonparticulate Steroid Injections for Musculoskeletal Conditions
Status: RECRUITING
Conditions: Osteoarthritis|Tendinopathy|Impingement Shoulder
Interventions: DRUG: Triamcinolone or Betamethasone|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Commercial and Phase 3 of PF-04965842 Formulations, Estimation of Effect of Food on Commercial Formulation
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: P3-Fast|DRUG: Comm-Fast|DRUG: Vari-Fast|DRUG: Comm-Fed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Atrial Fibrillation Without Hemodynamic Instability in the Intensive Care Unit
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: amiodarone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prandial Metabolic Phenotype in Adults
Status: RECRUITING
Conditions: Protein Metabolism
Interventions: DIETARY_SUPPLEMENT: Total Amino Acids|DIETARY_SUPPLEMENT: Essential Amino Acids|DIETARY_SUPPLEMENT: Essential Amino Acids + Hydroxy-methylbutyric acid (HMB)|DIETARY_SUPPLEMENT: Essential Amino Acids + Leucine|DIETARY_SUPPLEMENT: Essential Amino Acids High|DIETARY_SUPPLEMENT: Placebo Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Single Doses of APN1125 in Healthy Normal Subjects
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: APN1125|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Run, Recovery, Repeat, Always Healthy ("Corre, Recupera, Repite, Siempre Saludable")
Status: COMPLETED
Conditions: Physical Exertion
Interventions: OTHER: Athletics track|OTHER: Elliptical machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of ACT Now GAIN Later
Status: ENROLLING_BY_INVITATION
Conditions: Psychological Flexibility|Child Behavior|Relationship, Parent Child|Well-Being, Psychological|Self-efficacy
Interventions: BEHAVIORAL: ACT Now GAIN Later|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Peer-Delivered Behavioral Activation for Methadone Adherence - Pilot Phase
Status: COMPLETED
Conditions: Substance Use|Substance Use Disorders|Opioid-use Disorder|Peer Delivered|Medication for Opioid Use Disorder (MOUD)|Methadone Treatment|Retention in Care|Behavioral Activation
Interventions: BEHAVIORAL: Peer-Delivered Behavioral Activation (Peer Activate)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Collect Pre-existing Data on the Administration of Cabozantinib in Participants With Advanced Renal Cell Carcinoma (aRCC) Who Initiated Cabozantinib in 2nd Line in a Real-life Clinical Setting in France.
Status: COMPLETED
Conditions: Advanced Renal Cell Carcinoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fludeoxyglucose F 18 PET Scan-Guided Therapy or Standard Therapy in Treating Patients With Previously Untreated Stage I or Stage II Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: DRUG: ABVD q4 weeks|DRUG: BEACOPP escalated q3 weeks|RADIATION: IN-RT 30 Gy (+ boost 6 Gy residual)|PROCEDURE: FDG-PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Tarceva for Untreated, Good Prognosis Patients With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Erlotinib (Tarceva)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Endovascular Repair of Ascending Aortic Pathologies
Status: RECRUITING
Conditions: Dissection of Thoracic Aorta
Interventions: DEVICE: Valiant PS-IDE Stent Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conditioning & Open-Label Placebo (COLP) for Opioid Management in Intensive Inpatient Rehabilitation
Status: RECRUITING
Conditions: Spinal Cord Injuries|Polytrauma|Burns
Interventions: OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of the Innovated Seifi's Functional Appliance on Skeletal and Dentoalveolar Changes of Class II/ 1, Deep Bite
Status: UNKNOWN
Conditions: Orthodontic Appliance Design|Retrognathism|Malocclusion, Angle Class II|Deepbite
Interventions: DEVICE: Seifi's Functional
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epigenetic Regulation of Osteogenesis Imperfecta Severity : miROI Study
Status: COMPLETED
Conditions: Osteogenesis Imperfecta
Interventions: BIOLOGICAL: Blood sample|BIOLOGICAL: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase II Study of KUC-7483 in Patients With Overactive Bladder
Status: COMPLETED
Conditions: Overactive Bladder (OAB)
Interventions: DRUG: KUC-7483|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Study of Reducing Adverse Effects After Radiofrequency Ablation Combined With Sclerotherapy
Status: NOT_YET_RECRUITING
Conditions: Vascular Diseases, Peripheral|Venous Insufficiency of Leg|Varicose Veins of Lower Limb
Interventions: DRUG: Sulodexide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Memory Preservation of Prophylactic Cranial Irradiation With Hippocampal Avoidance (PREMER-TRIAL)
Status: COMPLETED
Conditions: Small Cell Lung Carcinoma
Interventions: RADIATION: Prophylactic cranial irradiation (PCI)|RADIATION: Hippocampal avoidance PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Interventions to Prevent Falls. PRECAISAL Study
Status: WITHDRAWN
Conditions: Accidental Falls|Old Age; Debility|Activity, Motor
Interventions: BEHAVIORAL: Individual treatment|BEHAVIORAL: Groupal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Rifampin on the Pharmacokinetics of Linifanib in Subjects With Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: Linifanib|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Omega-3 Fatty Acid in Treating Pain in Patients With Breast or Ovarian Cancer Receiving Paclitaxel
Status: COMPLETED
Conditions: Breast Cancer|Ovarian Neoplasm|Pain
Interventions: DIETARY_SUPPLEMENT: Omega-3 fatty acid|DIETARY_SUPPLEMENT: Placebo|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 2 Multi-Center Study of Entinostat (SNDX-275) in Patient With Relapsed or Refractory Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Hodgkin's Lymphoma
Interventions: DRUG: Entinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Redirected Autologous T Cells Engineered to Contain Humanized Anti-CD19 in Patients With Relapsed or Refractory CD19+ Leukemia and Lymphoma Previously Treated With Cell Therapy
Status: COMPLETED
Conditions: Acute Lymphocytic Leukemia|Diffuse Large Cell Lymphoma
Interventions: BIOLOGICAL: huCART19
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carboplatin or Docetaxel in Treating Women With Metastatic Genetic Breast Cancer
Status: COMPLETED
Conditions: brca1 Mutation Carrier|brca2 Mutation Carrier|Breast Cancer|Hereditary Breast/Ovarian Cancer (brca1, brca2)
Interventions: DRUG: carboplatin|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exclusive Enteral Nutrition in Patients With Ileocaecal Crohn's Disease
Status: RECRUITING
Conditions: Crohn Disease|Nutrient; Excess|Remission/Regression
Interventions: DIETARY_SUPPLEMENT: EEN (Nestle Modulen®)|DRUG: Standart of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Dupilumab's Effects on Airway Inflammation in Patients With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Placebo|DRUG: Dupilumab SAR231893/REGN668|DRUG: fluticasone propionate and salmeterol|DRUG: budesonide and formoterol|DRUG: mometasone furoate and formoterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Individualized Chiropractic and Integrative Care for Low Back Pain
Status: COMPLETED
Conditions: Sub-Acute and Chronic Low Back Pain
Interventions: OTHER: Chiropractic care|OTHER: Multidisciplinary, integrative care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Recovery Protocols Combination in Soccer Players
Status: UNKNOWN
Conditions: Soccer|Physical Stress|Fatigue
Interventions: OTHER: Foam Roller (FR)|OTHER: Stretching (STR)|OTHER: Cold-Water Immersion (CWI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Gemcitabine Hydrochloride and Genistein in Treating Women With Stage IV Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DIETARY_SUPPLEMENT: genistein|DRUG: gemcitabine|PROCEDURE: Tumor biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Panobinostat and Everolimus in Treating Patients With Recurrent Multiple Myeloma, Non-Hodgkin Lymphoma, or Hodgkin Lymphoma
Status: COMPLETED
Conditions: Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|B-cell Adult Acute Lymphoblastic Leukemia|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hepatosplenic T-cell Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Post-transplant Lymphoproliferative Disorder|Primary Central Nervous System Non-Hodgkin Lymphoma|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Multiple Myeloma|Splenic Marginal Zone Lymphoma|T-cell Adult Acute Lymphoblastic Leukemia|Waldenström Macroglobulinemia
Interventions: DRUG: panobinostat|DRUG: everolimus|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open to Laparoscopic Reverse Conversion of Perforated Appendicitis
Status: COMPLETED
Conditions: Laparoscopic Surgery|Acute Appendicitis With Rupture|Sepsis|Abdominal Abscess
Interventions: PROCEDURE: reverse conversion technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Staccato Apomorphine Multi-dose PK and PD in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: 009-A1|DRUG: 009-A2|DRUG: 009-A3|DRUG: 009-A0|DRUG: 009-B1 (active --> placebo) crossover|DRUG: 009-B2 (placebo --> active) crossover
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pulpotomy vs Root Canal Treatment for Teeth With Symptomatic Irreversible Pulpitis
Status: ENROLLING_BY_INVITATION
Conditions: Pulpitis - Irreversible
Interventions: PROCEDURE: Complete Pulpotomy|PROCEDURE: Pulpectomy and Root Canal Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial on Contraceptive Efficacy, Safety and Tolerability of LVDS (Levonorgestrel Vaginal Delivery System) During 13 Cycles
Status: RECRUITING
Conditions: Contraception
Interventions: COMBINATION_PRODUCT: LVDS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Antineoplaston Therapy in Treating Patients With Metastatic Prostate Cancer
Status: TERMINATED
Conditions: Metastatic Prostate Cancer
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy and Chemotherapy With or Without Tetanus Toxoid Compared With Chemotherapy Alone in Treating Patients With Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: ALVAC-CEA-B7.1 vaccine|BIOLOGICAL: tetanus toxoid|DRUG: FOLFIRI regimen|DRUG: fluorouracil|DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Radiosurgery in Metastatic Spinal Cord Compression
Status: TERMINATED
Conditions: Spinal Cord Compression|Neoplasm Metastasis
Interventions: PROCEDURE: Decompression surgery|RADIATION: Radiosurgery|RADIATION: Fractionated Radiotherapy|DRUG: Glucocorticoids|DRUG: Pantoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibrutinib in Treating Patients With Refractory or Relapsed Lymphoma After Donor Stem Cell Transplant
Status: COMPLETED
Conditions: Blastoid Variant Mantle Cell Lymphoma|Recurrent Chronic Lymphocytic Leukemia|Recurrent Follicular Lymphoma|Recurrent Hodgkin Lymphoma|Recurrent Mantle Cell Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Follicular Lymphoma|Refractory Hodgkin Lymphoma|Refractory Mantle Cell Lymphoma
Interventions: DRUG: Ibrutinib|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gradual Withdrawal of Remifentanil Infusion Reduced Postoperative Pain and Opioid Requirement During Breast Surgery
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase II Evaluation of AHCC for the Eradication of HPV Infections
Status: COMPLETED
Conditions: Human Papilloma Virus|Dysplasia|CIN1|CIN2
Interventions: DIETARY_SUPPLEMENT: AHCC 3 grams once a day|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Antibody Levels in Children and Adolescents After Initiation of Insulin Therapy by Either Insulin Aspart or Soluble Human Insulin
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: soluble human insulin|DRUG: isophane human insulin|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online Cognitive Behavioural Therapy for Substance Use Disorder: The Impact of Peer Support
Status: RECRUITING
Conditions: Substance Use Disorders
Interventions: BEHAVIORAL: Online Cognitive Behavioural Therapy|BEHAVIORAL: Individual Peer Support|BEHAVIORAL: Group Peer Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Safety Study of Brentuximab Vedotin (SGN-35)
Status: COMPLETED
Conditions: Disease, Hodgkin|Lymphoma, Large-Cell, Anaplastic|Lymphoma, Non-Hodgkin
Interventions: DRUG: brentuximab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Virtual Reality (VR) in Patients With Sickle Cell Disease (SCD)
Status: TERMINATED
Conditions: Sickle Cell Disease|Virtual Reality|Anxiety|Depression|Cancer
Interventions: DEVICE: Relaxation response and virtual reality (VR) session
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparing High and Normal Protein Diets for the Dietary Remission of Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Type 2|Obesity|Diet Modification
Interventions: BEHAVIORAL: High Protein Diet|BEHAVIORAL: Standard Protein Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Amivantamab in Participants With Previously Treated Advanced or Metastatic Gastric or Esophageal Cancer
Status: TERMINATED
Conditions: Stomach Neoplasms|Esophageal Neoplasms
Interventions: DRUG: Amivantamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostatic Neoplasms
Interventions: DRUG: Niraparib|DRUG: Abiraterone Acetate (AA)|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Acne Treatment With Active Patches Which Contains Azelaic Acid, Citric Acid,Salicylic Acid and 2% Ascorbic Acid
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DEVICE: OPLON active patch|DEVICE: Sham patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Compare the Efficacy and Safety of Rosuvastatin/Ezetimibe Combination Therapy Versus Rosuvastatin Monotherapy in Korean Patients With Left Ventricular Diastolic Dysfunction and Hyperlipidemia
Status: UNKNOWN
Conditions: Left Ventricular Diastolic Dysfunction|Hyperlipidemias
Interventions: DRUG: Rosuvastatin 20|DRUG: Rosuvamibe 10/10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia
Status: UNKNOWN
Conditions: Stroke|Coronary Artery Disease|Arrhythmia
Interventions: PROCEDURE: Digital subtraction angiography and 24-hour simultaneous recorder of electrocardiograph
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC