pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluation of Diagnostic Accuracy, Safety, and Cost-Effectiveness of the Non-Invasive Cardiolens FFR-CT Pro Method to Measure the Fractional Flow Reserve in Diagnostics of Chronic Coronary Syndromes Versus the Standard Diagnostic Modalities.
Status: COMPLETED
Conditions: Stable Ischemic Heart Disease|Coronary Artery Disease
Interventions: PROCEDURE: CCTA (Coronary Computed Tomography Angiography)|PROCEDURE: ICA (Invasive Coronary Angiography)|PROCEDURE: FFR (Fractional Flow Reserve)|DEVICE: CNBP measurement|DEVICE: Cardiolens FFR-CT Pro
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ultrasound Three-dimensional Characterization of Ovarian Morphology in Women With Polycystic Ovary Syndrome (PCOS)
Status: UNKNOWN
Conditions: PCOS|Hyperandrogenism
Interventions: PROCEDURE: Ultrasound|PROCEDURE: Determination of concentrations of androgens|DEVICE: Three dimensional ultrasound probe
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Diet Intervention for Hypertension: Adaptation and Dissemination to Native Communities
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: DASH Groceries + Weekly Sessions|BEHAVIORAL: Groceries + Brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute and Chronic Effect of His-pacing in Consecutive Patients With AV-block
Status: COMPLETED
Conditions: Atrioventricular Block
Interventions: OTHER: Septal pacing|OTHER: His lead activated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Medical Treatment of Early-Enamel Carious Lesion Using Different Remeneralizing Agents
Status: COMPLETED
Conditions: Enamel Caries
Interventions: DRUG: Silver diamine fluoride- potassium iodide|DRUG: Casein phosphopeptide amorphous calcium phosphate|DRUG: experimental tricalcium silicate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Medical Versus Surgical Treatment for Peritonsillar Abscesses
Status: WITHDRAWN
Conditions: Peritonsillar Abscess|Surgical Incision
Interventions: DRUG: Medical Management Alone Arm|PROCEDURE: Surgical Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: CD19-Specific T-cells in Treating Patients With Advanced Lymphoid Malignancies
Status: COMPLETED
Conditions: Acute Biphenotypic Leukemia|Acute Lymphoblastic Leukemia|Blasts 5 Percent or More of Bone Marrow Nucleated Cells|CD19 Positive|Minimal Residual Disease|Non-Hodgkin Lymphoma|Small Lymphocytic Lymphoma|Stage III Chronic Lymphocytic Leukemia|Stage IV Chronic Lymphocytic Leukemia
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Tisagenlecleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: E-cigarette Harm Reduction Among PLWHA in South Africa
Status: NOT_YET_RECRUITING
Conditions: Tobacco Smoking
Interventions: OTHER: Nicotine Replacement Therapy (NRT)|OTHER: E-Cigarette (EC)|BEHAVIORAL: Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 12-week Study to Compare the Efficacy and Safety of Albuterol Spiromax® Versus a Placebo in People 12 Years and Older With Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Placebo MDPI|DRUG: Albuterol MDPI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study With Gemcitabine and RTA 402 for Patients With Unresectable Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Neoplasms|Pancreatic Cancer
Interventions: DRUG: Bardoxolone methyl|DRUG: Bardoxolone methyl|DRUG: Bardoxolone methyl|DRUG: Bardoxolone methyl|DRUG: Bardoxolone methyl|DRUG: Bardoxolone methyl|DRUG: Bardoxolone methyl|DRUG: Gemcitabine|DRUG: Placebo|DRUG: Bardoxolone methyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Low Glycemic Index (GI) Diet on Cardiometabolic Outcomes Among Obese Chinese Adults
Status: COMPLETED
Conditions: Obesity|Central Obesity
Interventions: BEHAVIORAL: Low GI diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Iron Fortification Trail Using NaFeEDTA in Iron Deficient Lead-exposed Children
Status: COMPLETED
Conditions: Iron Deficiency|Lead Poisoning
Interventions: DIETARY_SUPPLEMENT: iron fortified biscuits|DIETARY_SUPPLEMENT: iron fortified biscuits|DIETARY_SUPPLEMENT: iron fortified biscuits|DIETARY_SUPPLEMENT: iron fortified biscuits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Local Antioxidant Therapy Vasoconstriction Effects in Different Races
Status: COMPLETED
Conditions: Cardiovascular Diseases|Cardiovascular Risk Factor|Vasoconstriction
Interventions: DRUG: Control (Norepinephrine)|DRUG: Norepinephrine + Ascorbic Acid|DRUG: Norepinephrine + L-NAME|DRUG: Norepinephrine + L-NAME + Ascorbic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Efficacy of Serotoninergic Antidepressants in Bulimia Nervosa, According to Brain Serotonin Profile Determined by Positron Emission Tomography With [18F] MPPF.
Status: COMPLETED
Conditions: Bulimia Nervosa
Interventions: DRUG: Antidepressants|DRUG: Positron Emission Tomography (PET)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Uterine Closure at C-section by Stratafix Tissue Control Device: Randomized Case-Control Study
Status: COMPLETED
Conditions: Cesarean Section
Interventions: PROCEDURE: Closure of uterine incision at C section
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjustment of DOses of NIcotine in Smoking Cessation (ADONIS)
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: PROCEDURE: Dose adjustment of nicotine replacement therapies|DRUG: nicotine patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Electro Physiological Responses to Kabat Motor Control Re-education on Bell's Palsy: A Randomized Controlled Study
Status: COMPLETED
Conditions: Facial Nerve Palsy|Bell's Palsy
Interventions: OTHER: Kabat motor control re-education therapy|OTHER: conventional selected program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma
Status: COMPLETED
Conditions: Apexification|Apexogenesis|Pulp Necrosis|MTA|Pulp Revascularisation|Periapical Periodontitis|Non-vital Immature Tooth
Interventions: PROCEDURE: Mineral trioxide aggregate|PROCEDURE: Revascularisation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Probiotic on the Glycemic Profile and the Fecal Microbiota of Prediabetic Subjects (PREDIABETCARE)
Status: COMPLETED
Conditions: PreDiabetes|Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Precision Treatment of Lumbar Spine Surgery Through Advanced Nerve Root Blockade
Status: RECRUITING
Conditions: Radiculopathy Lumbar|Radiculopathy Sacral|Herniated Disc|Foraminal Stenosis|Stenosis, Spinal
Interventions: DIAGNOSTIC_TEST: Selective nerve root block (SNRB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Improving the Referral of Patients With Suspected Cognitive Impairment and Early Dementia
Status: NOT_YET_RECRUITING
Conditions: Cognitive Dysfunction|Mild Cognitive Impairment
Interventions: DIAGNOSTIC_TEST: Mini Mental State Examination|DIAGNOSTIC_TEST: Montreal Cognitive Assessment|DEVICE: Brain on Track (version BOT.0.0.0 03.03.2023)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Clearance of NRL972 in Patients With Cirrhosis and in Healthy Volunteers
Status: COMPLETED
Conditions: Hepatic Cirrhosis
Interventions: DRUG: NRL972|DRUG: NRL972|DRUG: NRL972|DRUG: NRL972|DRUG: NRL972|DRUG: NRL972
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study Evaluating Efficacy & Safety of Afuresertib Plus Fulvestrant in Patients w/ Locally Advanced or Metastatic HR+/HER2- Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Afuresertib|DRUG: Afuresertib/placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Burch Colposuspension to Reduce Occult Stress Incontinence
Status: COMPLETED
Conditions: Pelvic Organ Prolapse|Urinary Incontinence,Stress|Urinary Incontinence, Urge|Bowel Dysfunction|Sexual Dysfunction
Interventions: PROCEDURE: Laparoscopic Burch Colposuspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Canakinumab Treatment for CRS in Participants With COVID-19-induced Pneumonia
Status: COMPLETED
Conditions: Cytokine Release Syndrome (CRS) in Patients With COVID-19-induced Pneumonia
Interventions: DRUG: Canakinumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Utilizing Text Messaging to Improve Vehicle Safety Among At-Risk Young Adults
Status: COMPLETED
Conditions: Risk Reduction
Interventions: BEHAVIORAL: SMS Dialogue|BEHAVIORAL: SMS Assessments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Informative Tools to Optimize Neoadjuvant Therapy in ER Positive, HER2 Negative Breast Cancers
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DIAGNOSTIC_TEST: Intervention 1|DIAGNOSTIC_TEST: Intervention 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Oral Ixazomib Citrate (MLN9708) Maintenance Therapy in Participants With Multiple Myeloma Following Autologous Stem Cell Transplant
Status: COMPLETED
Conditions: Multiple Myeloma|Autologous Stem Cell Transplant
Interventions: DRUG: Ixazomib Citrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of HMB Supplementation on Adipose Tissue Inflammation and Metabolism
Status: TERMINATED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: HMB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Working Memory Training Combined With Transcranial Magnetic Stimulation in Smokers
Status: COMPLETED
Conditions: Tobacco Use Disorder
Interventions: OTHER: Working Memory Training|OTHER: Sham Working Memory Training|DEVICE: repetitive Transcranial Magnetic Stimulation|DEVICE: Sham repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of INCMGA00012 in Metastatic Merkel Cell Carcinoma (POD1UM-201)
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Merkel Cell Carcinoma
Interventions: DRUG: Retifanlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of the Simultaneous Treatment of Upper Facial Lines (Horizontal Forehead Lines, Glabellar Frown Lines and Lateral Canthal Lines) in Subjects With Moderate to Severe Upper Facial Lines
Status: COMPLETED
Conditions: Moderate to Severe Upper Facial Lines (Horizontal Forehead Lines, Glabellar Frown Lines, and Lateral Canthal Lines)
Interventions: DRUG: NT 201|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Sea Buckthorn Oil on Dry Eye
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DIETARY_SUPPLEMENT: Sea buckthorn (Hippophaë rhamnoides) oil|DIETARY_SUPPLEMENT: Placebo comparison
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Geographic Atrophy
Interventions: DRUG: APL-2|DRUG: APL-2|OTHER: Sham Procedure|OTHER: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Efficacy and Safety of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: Xanomeline and Trospium Chloride Capsules|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characterization of Persistent Pulmonary Abnormalities Following COVID-19 Pneumonia
Status: COMPLETED
Conditions: Pneumonia, Viral
Interventions: DIAGNOSTIC_TEST: pulmonary anomalies 4 months after documented COVID-19 pneumonia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Insulin-Only Bionic Pancreas Pivotal Trial
Status: COMPLETED
Conditions: Diabetes Mellitus|Type 1 Diabetes|Diabetes Mellitus, Type 1
Interventions: COMBINATION_PRODUCT: Bionic Pancreas (BP) with Aspart or Lispro|COMBINATION_PRODUCT: Bionic Pancreas with Fiasp (BPFiasp)|OTHER: Usual Care (UC)|OTHER: BP Guidance Insulin Dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALLIANCE Mitral: Safety and Effectiveness of SAPIEN X4 Transcatheter Heart Valve - Mitral
Status: NOT_YET_RECRUITING
Conditions: Mitral Regurgitation|Mitral Valve Disease|Mitral Stenosis
Interventions: DEVICE: SAPIEN X4 THV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate Efficacy and Safety of LIB003, Evolocumab and Alirocumab in High-risk CVD Patients
Status: COMPLETED
Conditions: Hypercholesterolemia|Cardiovascular Diseases
Interventions: BIOLOGICAL: lerodalcibep|BIOLOGICAL: evolocumab|BIOLOGICAL: alirocumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of an Adaptive Sensory Environment in Autism Spectrum Disorder (ASD) Patients in the Perioperative Environment
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Anesthesia|Procedural Anxiety|Sensory Processing Disorder
Interventions: OTHER: Sensory adaptive environment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Potential Injection of Human Umbilical Cord Secretome in the Case of Trophic Ulcers (Pre-post Intervention)
Status: COMPLETED
Conditions: CM-MSC ; Stem Cell ; Trophic Ulcer ; Leprosy ; Morbun Hansen; Secretom
Interventions: BIOLOGICAL: Secretome
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease Who Failed Prior Biologic Treatment
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: placebo for risankizumab IV|DRUG: risankizumab SC|DRUG: risankizumab IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Innovative Tax Proposals on Purchase Patterns
Status: RECRUITING
Conditions: Cigarette Smoking
Interventions: BEHAVIORAL: Market Price Condition (control)|BEHAVIORAL: Tobacco Parity Tax Condition|BEHAVIORAL: Nicotine-Content Tax Condition|BEHAVIORAL: Harm-Reduction Tax Condition|BEHAVIORAL: Modified Risk Tobacco Product (MRTP) Tax Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Functional Recovery Measurement : Comparing Early Active Mobilization Versus Immobilization After Extensor Tendon Repair in Zones IV to VIII
Status: COMPLETED
Conditions: Injury of Extensor Tendon of Hand (Disorder)
Interventions: PROCEDURE: physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Correlation of Length of Index Finger to Vertical Dimensions of Occlusion for Edentulous Patients
Status: COMPLETED
Conditions: Patient Satisfaction|Dental Prosthesis|Edentulous Jaw
Interventions: PROCEDURE: Finger lengths|PROCEDURE: Conventional method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of an Ad26.RSV.preF-based Vaccine and High-dose Seasonal Influenza Vaccine, With and Without Coadministration, in Adults Aged 65 Years and Older
Status: COMPLETED
Conditions: Influenza, Human Prevention|Respiratory Syncytial Viruses Prevention
Interventions: BIOLOGICAL: Ad26.RSV.preF-based vaccine|BIOLOGICAL: Quadrivalent High-dose Influenza Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Instrument-assisted Soft Tissue Mobilization and Phonophoresis on Trigger Points of Tension Headache
Status: COMPLETED
Conditions: Headache|Tension-Type Headache
Interventions: OTHER: Conventional physical therapy program|OTHER: IASTM by M2t blade|DEVICE: Phonophoresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Laser Acupuncture in Different Meridians on the Autonomic Nervous System and Its Brain Mechanisms
Status: RECRUITING
Conditions: Laser Acupuncture|Meridian|Heart Rate Variability|Brain Mechanism
Interventions: DEVICE: Laser acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: CD7 CAR-T for Patients With r/r CD7+ T-ALL/T-LBL
Status: RECRUITING
Conditions: Neoplasms|Hematologic Neoplasms|Neoplasms by Site|Hematologic Diseases
Interventions: DRUG: RD13-02 cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dual Artery Compression vs. Radial Artery-Only Hemostasis: Impact on Radial Artery Occlusion (EASY-RAO)
Status: UNKNOWN
Conditions: Radial Artery Injury
Interventions: DEVICE: Hemostasis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Apixaban for the Prevention of Latent Biological Valve Thrombosis
Status: RECRUITING
Conditions: Aortic Valve Replacement|Antithrombotic Therapy|Bioprosthetic Valve Thrombosis|Rapid Deployment Valves
Interventions: PROCEDURE: Aortic valve replacement surgery|DIAGNOSTIC_TEST: Computed tomography|DIAGNOSTIC_TEST: Echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Global Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Women With Moderate to Severe Endometriosis-associated Pain
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: Elagolix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use Of Pontic Shield Technique For Alveolar Ridge Preservation . A Case Series
Status: UNKNOWN
Conditions: To Assess Bucco-lingual Dimension of the Ridge While Using Pontic Shield Technique as a Treatment Modality for Ridge Preservation
Interventions: PROCEDURE: Pontic Shield Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary Care - Prescribing Lifestyle Adjustments for Cardiovascular Health
Status: SUSPENDED
Conditions: Behavior Change Interventions|Cardiovascular Diseases|Cardiovascular Risk Factor|Behavior, Health
Interventions: BEHAVIORAL: Lifestyle Prescription (LRx)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Competition With Striatal [11C]ORM-13070 Binding by Atipamezole and Endogenous Noradrenaline
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Atipamezole|DRUG: Atomoxetine|DRUG: Ketamine|OTHER: Cold pressor test|DRUG: Insulin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vorinostat and Temsirolimus With or Without Radiation Therapy in Treating Younger Patients With Newly Diagnosed or Progressive Diffuse Intrinsic Pontine Glioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Diffuse Intrinsic Pontine Glioma
Interventions: RADIATION: Radiation Therapy|DRUG: Temsirolimus|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of p144 to Treat Skin Fibrosis in Systemic Sclerosis
Status: COMPLETED
Conditions: Skin Fibrosis
Interventions: DRUG: P144|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Two Regimens of Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed Localized Ewing Sarcoma Family of Tumors
Status: COMPLETED
Conditions: Ewing Sarcoma of Bone|Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Interventions: OTHER: radiation therapy|OTHER: therapeutic conventional surgery|DRUG: etoposide|DRUG: ifosfamide|DRUG: doxorubicin hydrochloride|DRUG: cyclophosphamide|DRUG: vincristine sulfate|DRUG: topotecan hydrochloride|BIOLOGICAL: filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dry Needling on Muscle Mechanical Properties and Muscle Contractility in Latent Trigger Points
Status: COMPLETED
Conditions: Trigger Point Pain, Myofascial
Interventions: DEVICE: Intervention-Dry Needling|DEVICE: Control-Dry Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Platelet Dose Strategy for Management of Thrombocytopenia
Status: COMPLETED
Conditions: Thrombocytopenia
Interventions: PROCEDURE: Medium Dose Prophylactic Platelet Transfusions|PROCEDURE: Lower Dose Prophylactic Platelet Transfusions|PROCEDURE: Higher Dose Prophylactic Platelet Transfusions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Shigella CVD 31000: Study of Responses With Shigella-ETEC Vaccine Strain CVD 1208S-122
Status: ACTIVE_NOT_RECRUITING
Conditions: Shigella Infection|Enterotoxigenic Escherichia Coli Infection
Interventions: BIOLOGICAL: strain CVD 1208S-122|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Three Tranexamic Acid Dose Regimens in Patients Undergoing Cardiac Valve Surgery
Status: COMPLETED
Conditions: Cardiac Surgical Procedures|Blood Transfusion|Tranexamic Acid
Interventions: DRUG: Tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Pregabalin on Immediate Post-operative and Longterm Pain
Status: COMPLETED
Conditions: Scoliosis|Spondylolisthesis
Interventions: DRUG: Pregabalin|DRUG: Sugar pill|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TRV-chair vs Manual Repositioning Maneuver in Treatment of Benign Paroxysmal Positional Vertigo
Status: COMPLETED
Conditions: BPPV
Interventions: DEVICE: TRV-chair|PROCEDURE: Manual repositioning maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Aliskiren on Proteinuria
Status: COMPLETED
Conditions: Chronic Kidney Disease|Proteinuria|Blood Pressure
Interventions: DRUG: Aliskiren, Perindopril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Digital Health Technology Interventions to Increase Skill Acquisition and Utilization
Status: RECRUITING
Conditions: Bulimia Nervosa|Bulimia|Binge Eating|Binge-Eating Disorder
Interventions: BEHAVIORAL: Behavioral Therapy for Eating Disorders|BEHAVIORAL: Skills Monitoring On|BEHAVIORAL: Automated Reminder Messages|BEHAVIORAL: JITAIs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors (FH-A11KRASG12V-TCR) in Treating Patients With Metastatic Pancreatic, Colorectal and Non-Small Cell Lung Cancers With KRAS G12V Mutations
Status: RECRUITING
Conditions: Metastatic Colorectal Adenocarcinoma|Metastatic Lung Non-Small Cell Carcinoma|Metastatic Pancreatic Adenocarcinoma|Stage IV Colorectal Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8
Interventions: DRUG: Bendamustine|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Cyclophosphamide|PROCEDURE: Echocardiography|DRUG: Fludarabine|PROCEDURE: Leukapheresis|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Multigated Acquisition Scan|PROCEDURE: Positron Emission Tomography|BIOLOGICAL: T-cell Receptor-engineered T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of a Developmental,Individual-Difference,Relationship-Bases/Floortime Intervention for Children With Autistic
Status: COMPLETED
Conditions: Autism Spectrum Disorders
Interventions: BEHAVIORAL: DIR/Floortime parent intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study on Artelon® Tissue Reinforcement in Repair of Chronic Ruptures and Re-ruptures of the Achilles Tendon
Status: TERMINATED
Conditions: Achilles Tendon Rupture
Interventions: DEVICE: Artelon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of L-Ornithine L-Aspartate and Polyethylene Glycol in Cirrhotic Patients With Overt Hepatic Encephalopathy
Status: NOT_YET_RECRUITING
Conditions: Hepatic Encephalopathy Stage 2|Hepatic Encephalopathy Stage 3|Hepatic Encephalopathy Stage 4
Interventions: DRUG: Polyethylene Glycols|DRUG: Lactulose oral solution|DRUG: L-ornithine L-aspartate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Group Exercise Training for Functional Improvement After Treatment (The GET FIT Trial)
Status: COMPLETED
Conditions: Malignant Neoplasm|Postmenopausal
Interventions: BEHAVIORAL: Exercise Intervention|BEHAVIORAL: Exercise Intervention|BEHAVIORAL: Exercise Intervention|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Optimizing Uptake of Methylaminolevulinat With Fractional Ablative Laser Technique
Status: COMPLETED
Conditions: Photodynamic Therapy|Ablative Fractional Laser
Interventions: PROCEDURE: Laser+Methylaminolevulinat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Scheme of Shu Gan yi Yang Capsule
Status: UNKNOWN
Conditions: Depression With Erectile Dysfunction
Interventions: DRUG: shu gan yi yang capsule|DRUG: shu gan yi yang capsule simulation agent|OTHER: Supportive psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of SHR0302 in Adult Patients With Severe Alopecia Areata
Status: ACTIVE_NOT_RECRUITING
Conditions: Alopecia Areata
Interventions: DRUG: SHR0302|DRUG: SHR0302|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Investigating Bioequivalence Between a Single Dose of Formulation 2 and Formulation 3 of MEDI0382
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: MEDI0382 Formulation 2|DRUG: MEDI0382 Formulation 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: PANVAC-V and PANVAC-F Vaccines Plus Sargramostim to Treat Advanced Cancer
Status: COMPLETED
Conditions: Adenocarcinoma|Colorectal Cancer|Ovarian Cancer|Breast Cancer
Interventions: BIOLOGICAL: PANVAC-V|BIOLOGICAL: PANVAC-F|DRUG: Sargramostim (GM-CSF, Leukine)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of a New Technique Utilizing a Biologic Glue and Tissue Patch to Seal the Cut Edge of the Pancreas Following Removal of the Tail of the Pancreas
Status: UNKNOWN
Conditions: Pancreatic Fistula|Distal Pancreatectomy Complications|Falciform Patch Pancreatic Closure|Fibrin Glue Pancreatic Closure
Interventions: PROCEDURE: Falciform patch and fibrin glue application|PROCEDURE: standard pancreatic closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dissemination of a Tailored Tobacco Quitline for Rural Veteran Smokers
Status: UNKNOWN
Conditions: Nicotine Dependence|Tobacco Use
Interventions: DRUG: Nicotine replacement therapy - Transdermal nicotine patch|DRUG: Nicotine replacement therapy - Nicotine gum|DRUG: Nicotine replacement therapy - Nicotine lozenge|DRUG: Bupropion|DRUG: Varenicline|DRUG: Combination pharmacotherapy - Transdermal nicotine patch + nicotine gum|DRUG: Combination pharmacotherapy - Transdermal nicotine patch + nicotine lozenge|DRUG: Combination pharmacotherapy - Transdermal nicotine patch + bupropion|BEHAVIORAL: Tobacco quitline referral|BEHAVIORAL: Tailored behavioral intervention|BEHAVIORAL: Alcohol use risk reduction|BEHAVIORAL: Behavioral activation for depressive symptoms|BEHAVIORAL: Behavioral management of postcessation weight gain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Detect Cryoimmunologic Response Induced by Early Breast Cancer Ultrasound-guided Cryoablation (ICE-study)
Status: COMPLETED
Conditions: Cancer, Treatment-Related|Tumor of Breast|Systemic Inflammatory Response|Stage I Breast Cancer
Interventions: DEVICE: cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Follow-up Study to Assess Safety and Clinical Activity of Continued AFFITOPE® AD02 Vaccinations of Patients Who Participated in AFF006
Status: TERMINATED
Conditions: Alzheimer´s Disease
Interventions: BIOLOGICAL: AFFITOPE® AD02|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Bioequivalence Study on Two Amlodipine Tablet 10mg Formulations
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BF-Amlodipine Tablet 10mg|DRUG: Norvasc Tablet 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Evaluation of an Asthma Treatment Strategy Based on Exhaled Nitric Oxide Measurements in Adolescents
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Inhaled corticosteroids|PROCEDURE: eNO measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Systemic Ropivacaine on Hyperalgesia, Flare Reaction and Peripheral Nerve Excitability
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: ropivacaine (Naropin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of BPM31510 With Vitamin K1 in Subjects With Newly Diagnosed Glioblastoma (GB)
Status: RECRUITING
Conditions: Glioblastoma|Glioblastoma Multiforme
Interventions: DRUG: BPM31510|OTHER: Vitamin K1|DRUG: Temozolomide (TMZ)|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Probiotic Mixture Supplementation and Evaluation of Intestinal Mucosal Tolerance and Gut Microbiome in Newborns With Perinatal Asphyxia Receiving Hypothermic Treatment
Status: UNKNOWN
Conditions: Asphyxia Neonatorum|Morbidity;Newborn
Interventions: DIETARY_SUPPLEMENT: Probiotic mixture|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: EIT Based Regional Lung Ventilation in Minimally Invasive Cardiac Surgery
Status: COMPLETED
Conditions: Patients Who Underwent CPB for MICS
Interventions: PROCEDURE: Ventilation during cardiopulmonary bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Compare Between Two Doses of Palonosetron on the Prevention of Postoperative Nausea and Vomiting in Obese Patients
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: palonosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: IFx-Hu2.0 for the Treatment of Patients With Skin Cancer
Status: COMPLETED
Conditions: Cutaneous Squamous Cell Carcinoma|Basal Cell Carcinoma
Interventions: BIOLOGICAL: IFx-Hu2.0
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ceragenin Coated Endotracheal Tubes for the Prevention of Ventilator Associated Pneumonia
Status: ACTIVE_NOT_RECRUITING
Conditions: Ventilator Associated Pneumonia
Interventions: DEVICE: CeraShield Endotracheal Tube|DEVICE: Endotracheal tube with subglottic secretion drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Preventive Regimens With Different Toothpastes vs Fluoride Varnish & Toothpaste in High Caries Patients
Status: COMPLETED
Conditions: Dental Caries
Interventions: OTHER: Himalaya complete care toothpaste|OTHER: Signal toothpaste|OTHER: Signal toothpaste and fluoride varnish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Development of Machine Learning Models for the Prediction of BMI and Complications After Bariatric Surgery (CABS-Study)
Status: RECRUITING
Conditions: Body Weight|Post-Op Complication|Anastomosis, Leaking|Hiatal Hernia|GERD|Internal Hernia|Mesenteric Hernia|Intussusception|Diabetes Mellitus, Type 2|Sleep Apnea, Obstructive
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Initiation of Non- Invasive Ventilation at Home Versus Hospital Among Patients With Overlap Syndrome
Status: UNKNOWN
Conditions: Overlap Syndrome
Interventions: OTHER: IniVAH|OTHER: IniVAD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 4 Study of Effect of Aspirin on Flushing in Dimethyl Fumarate-Treated Participants With Relapsing-Remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing-Remitting Multiple Sclerosis
Interventions: DRUG: dimethyl fumarate|DRUG: acetylsalicylic acid|DRUG: ASA-Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pegaptanib Sodium Compared to Sham Injection in Patients With DME Involving the Center of the Macula
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: pegaptanib sodium (Macugen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Avelumab Plus Intermittent Axitinib in Previously Untreated Patients With Metastatic Renal Cell Carcinoma
Status: RECRUITING
Conditions: Renal Carcinoma Metastatic
Interventions: DRUG: Axitinib Oral Tablet|DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Drainage With or Without Bleomycin Instillation for Malignant Pericardial Effusion
Status: COMPLETED
Conditions: Malignant Pericardial Effusion
Interventions: PROCEDURE: Observation alone after pericardial drainage|DRUG: Pericardial instillation of bleomycin after drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Integrating an Internet Weight Control Program Into Primary Care
Status: COMPLETED
Conditions: Overweight|Obese
Interventions: OTHER: Usual Care|BEHAVIORAL: Brief Physician Counseling|BEHAVIORAL: Referral and access to an internet weight control program|BEHAVIORAL: Brief follow up email notes from PCPs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyperglycemia, Exercise, and Endothelial Function
Status: COMPLETED
Conditions: Endothelial Function|Hyperglycemia
Interventions: BEHAVIORAL: GLU+EX|DIETARY_SUPPLEMENT: GLU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Asparagus Capsule Consumption and Blood Sugar and Lipids and Oxidative Stress
Status: COMPLETED
Conditions: Asparagus Capsule Consumption
Interventions: DIETARY_SUPPLEMENT: Asparagus capsule|OTHER: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Determinants of Mercaptopurine Toxicity in Paediatric Acute Lymphoblastic Leukemia Maintenance Therapy
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Mercaptopurine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of Rucaparib as Switch Maintenance After Platinum in Relapsed High Grade Serous or Endometrioid Ovarian Cancer (ARIEL3)
Status: COMPLETED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Cancer
Interventions: DRUG: Rucaparib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: OMT to Improve Feeding After Hypothermia
Status: COMPLETED
Conditions: Neonatal Encephalopathy|Feeding; Difficult, Newborn
Interventions: PROCEDURE: Osteopathic Manipulative Treatment (OMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FiH Study to Assess Safety and PK of SAD and MAD of ANT3310 Alone and in Combination With Meropenem in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: ANT3310|DRUG: ANT3310-placebo|DRUG: ANT3310|DRUG: ANT3310-placebo|DRUG: ANT3310-placebo|DRUG: ANT3310|DRUG: Meropenem|DRUG: Meropenem-placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Avelumab in Combination With Fluorouracil and Mitomycin or Cisplatin and Radiation Therapy in Treating Participants With Muscle-Invasive Bladder Cancer
Status: COMPLETED
Conditions: Bladder Carcinoma Infiltrating the Muscle of the Bladder Wall|Stage II Bladder Cancer AJCC v8|Stage II Renal Pelvis Cancer AJCC v8|Stage II Ureter Cancer AJCC v8|Stage II Urethral Cancer AJCC v8|Stage III Bladder Cancer AJCC v8|Stage III Renal Pelvis Cancer AJCC v8|Stage III Ureter Cancer AJCC v8|Stage III Urethral Cancer AJCC v8|Stage IIIA Bladder Cancer AJCC v8|Stage IIIB Bladder Cancer AJCC v8|Urethral Urothelial Carcinoma
Interventions: DRUG: Avelumab|DRUG: Cisplatin|DRUG: Fluorouracil|DRUG: Mitomycin|OTHER: Quality-of-Life Assessment|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Probiotics in the Prevention of Spontaneous Bacterial Peritonitis in Cirrhotic Patients: A Randomized Placebo Control Trial
Status: UNKNOWN
Conditions: Spontaneous Bacterial Peritonitis|Liver Cirrhosis
Interventions: DRUG: Probiotics and Placebo|DRUG: Probiotics and Norfloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Action Towards Health Equity and Improved Air Quality in the Duwamish Valley: A Multilevel Asthma Intervention
Status: RECRUITING
Conditions: Asthma in Children
Interventions: OTHER: MERV 13 filter|OTHER: Sham filter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Tezepelumab COPD Exacerbation Study
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: BIOLOGICAL: Tezepelumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: L-BLP25 in Patients With Colorectal Carcinoma After Curative Resection of Hepatic Metastases
Status: COMPLETED
Conditions: Colon Carcinoma|Rectum Carcinoma
Interventions: BIOLOGICAL: L-BLP25|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT