pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP)
Status: RECRUITING
Conditions: Sickle Cell Disease
Interventions: DRUG: Mitapivat|OTHER: Mitapivat-matching placebo|OTHER: Mitapivat-matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Nerve Blocks on Pain After Caesarean Section and Postpartum Depression
Status: ENROLLING_BY_INVITATION
Conditions: Postoperative Pain|Cesarean Section|Postpartum Depression
Interventions: PROCEDURE: Nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Optimization of Conditioning Regimen for HLA Matched HSCT in SAA
Status: RECRUITING
Conditions: Severe Aplastic Anemia
Interventions: DRUG: Busulfan|DRUG: Flu/Cy/ATG or Cy/ATG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hematopoietic Stem Cell Transplantation for the Treatment of Patients With Fanconi Anemia Lacking a Genotypically Identical Donor, Using a Chemotherapy Only Cytoreduction With Busulfan, Cyclophosphamide and Fludarabine
Status: COMPLETED
Conditions: Aplastic Anemia|Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: Busulfan, fludarabine, & cyclophosphamide with immunosuppression with ATG and cyclosporine.|DEVICE: CliniMACS device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuropattern - Assessment of a Translational Diagnostic Tool for Depression, Adjustment- and Somatoform-disorders
Status: UNKNOWN
Conditions: Major Depression|Minor Depression|Somatoform Disorders|Adjustment Disorders
Interventions: BEHAVIORAL: self-guided internet modules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Assess the Potential Effects of Rifampin on the Pharmacokinetics of Trabectedin in Patients With Advanced Malignancies
Status: COMPLETED
Conditions: Neoplasm Metastases
Interventions: DRUG: Sequence 1|DRUG: Sequence 2|DRUG: Sequence 1|DRUG: Sequence 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Trial to Test MVA-BN(R)-Filo and Ad26.ZEBOV Vaccines in Healthy Volunteers
Status: COMPLETED
Conditions: Ebola Disease|Marburg Disease
Interventions: BIOLOGICAL: Ad26 Zaire Ebola Vaccine|BIOLOGICAL: MVA Multi-Filo Ebola Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Dose-dependent Effect of Rosuvastatin on Long-term Clinical Outcomes After PCI
Status: UNKNOWN
Conditions: Coronary Artery Disease|Coronary Disease|Cardiovascular Diseases
Interventions: DRUG: Rosuvastatin 5mg|DRUG: Rosuvastatin 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Portal Vein Thrombosis on the Prognosis of Liver Cirrhosis
Status: COMPLETED
Conditions: Liver Cirrhosis|Portal Vein|Venous Thrombosis|Varicose Veins|Hemorrhage
Interventions: DRUG: Somatostatin and its analogs|PROCEDURE: Endoscopic sclerotherapy, endoscopic variceal ligation, endoscopic tissue glue injection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 1，Open-label Study of BPI-421286 in Subjects With Advanced Solid Tumors
Status: UNKNOWN
Conditions: Malignant Neoplasms|Metastatic Cancer
Interventions: DRUG: BPI-421286
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antibodies Responses to COVID-19 Infection in Hospitalized Patients
Status: UNKNOWN
Conditions: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV 2 Infection)|Hospitalized Patients|Laboratory-confirmed SARS-CoV 2 Infection
Interventions: DIAGNOSTIC_TEST: Testing procedure for Binding antibodies|DIAGNOSTIC_TEST: Neutralizing antibodies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of tDCS Combined With CBI on Postsurgical Pain
Status: RECRUITING
Conditions: Total Knee Arthroplasty (Postoperative Pain)|Total Hip Arthroplasty (Postoperative Pain)
Interventions: DEVICE: Transcranial Direct Current Stimulation|BEHAVIORAL: Cognitive-Behavioral (CB) intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of SKCPT in Patients With Knee Osteoarthritis: Phase III Clinical Trial
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: SKCPT|DRUG: Celebrex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liver Transplantation for Non-resectable Colorectal Liver Metastases: Translational Research
Status: RECRUITING
Conditions: Colorectal Cancer|Liver Metastases|Genetic Change
Interventions: OTHER: Liver transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Block vs. Placebo Block Study
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Nerve Block|Regional Anesthesia|Neuromuscular Blockade
Interventions: PROCEDURE: Erector spinae plane block|PROCEDURE: Placebo Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anlotinib and TQB2450 in Advanced Hepatocellular Carcinoma After Failure of Prior Immune Checkpoint Inhibitors
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Anlotinib and TQB2450
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interpersonal Therapy for Depression in Breast Cancer
Status: COMPLETED
Conditions: Major Depression
Interventions: BEHAVIORAL: Interpersonal Psychotherapy|BEHAVIORAL: Problem-Solving Therapy|BEHAVIORAL: Brief Supportive Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Capecitabine and Cisplatin to Treat Metastatic Triple Negative Breast Cancer
Status: UNKNOWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Cisplatin/Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of High Intensity Laser Therapy (HILT) in Patients With Subacromial Impingement Syndrome
Status: COMPLETED
Conditions: Subacromial Impingement Syndrome
Interventions: DEVICE: HILT|COMBINATION_PRODUCT: HILT & EXERCISE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8
Status: COMPLETED
Conditions: Pain
Interventions: OTHER: Room temperature|OTHER: Cold temperature|DRUG: Lidocain|DRUG: PF-05105679|DRUG: A967079|DRUG: PF-05089771|DRUG: PF-06305591
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: China Medical University Hospital (CMUH) Triapin Listing
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Ramipril + Felodipine|DRUG: Ramipril|DRUG: Ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CMV Vaccine (HB-101) in Kidney Transplant Patients
Status: COMPLETED
Conditions: Cytomegalovirus (CMV) Infection|Kidney Transplantation
Interventions: BIOLOGICAL: HB-101 vaccine|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison Between Infant Flow SiPAP and Noninvasive NAVA in the Neonatal Intensive Care Unit
Status: COMPLETED
Conditions: Respiratory Distress Syndrome
Interventions: DEVICE: Neurally Adjusted Ventilatory Assist (NAVA)|DEVICE: SiPAP - placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of Adapalene Gel,0.3% Versus Tretinoin Emollient Cream, 0.05% for the Treatment of Photoaging
Status: COMPLETED
Conditions: Photoaging|Photodamage
Interventions: DRUG: Adapalene|DRUG: Tretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Remifentanil in Extracorporeal Shock Wave Lithotripsy
Status: COMPLETED
Conditions: Kidney Calculi
Interventions: DRUG: Remifentanil|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Accuracy of INR Results From Patients Taking Phenprocoumon as Anticoagulant When Measured Using the Lumiradx INR Test
Status: COMPLETED
Conditions: Anticoagulants and Bleeding Disorders
Interventions: DIAGNOSTIC_TEST: Venous and Fingerstick blood draws|DIAGNOSTIC_TEST: Venous blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of the Addition of Ketamine to Sevoflurane Anesthesia in Electroconvulsive Therapy
Status: UNKNOWN
Conditions: Depressive Disorder
Interventions: DRUG: Sevoflurane|DRUG: Ketamine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Red Yeast Rice Beside Statin on Lipid Profile
Status: COMPLETED
Conditions: Hyperlipidemias
Interventions: DRUG: Red Yeast Rice Pill|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of 2 Doses of Tiotropium Via Respimat in Adult Patients With Mild Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: placebo|DRUG: tiotropium 2.5 mcg|DRUG: tiotropium 5 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Busulfan Plus Cyclophosphamide vs Fludarabine as a Conditioning Regimen
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: BuCy vs BuFlu
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALCMI-005: Pembrolizumab and Epacadostat in Treating Patients With Extensive Stage Small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Extensive Stage Small Cell Lung Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Epacadostat|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Redermic, Rejuva-A and Combination of Both Redermic and Rejuva-A in Subjects With Signs of Aging
Status: COMPLETED
Conditions: Skin Aging
Interventions: OTHER: Redermic|DRUG: Tretinoin (Rejuva-A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coeliac Artery Release or Sham Operation
Status: RECRUITING
Conditions: Mesenteric Ischemia|Median Arcuate Ligament Syndrome|Dunbar Syndrome|Coeliac Artery Compression|Celiac Artery Compression Syndrome
Interventions: PROCEDURE: Endoscopic Coeliac Artery Release (eCAR)|PROCEDURE: Sham Operation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Monitoring to Prevent Adverse Events foLlowing cardiOgenic Shock Trial
Status: RECRUITING
Conditions: Cardiogenic Shock|Heart Failure|Ambulatory Hemodynamic Monitoring
Interventions: DEVICE: CardioMEMS implantation with routine ambulatory pulmonary artery pressure monitoring and medication optimization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Natural History Studies of Mucopolysaccharidosis III
Status: COMPLETED
Conditions: Mucopolysaccharidosis Type IIIA|Mucopolysaccharidosis Type IIIB
Interventions: PROCEDURE: Lumbar puncture|DEVICE: Magnetic Resonance Imaging (MRI) of the brain
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Injection of Autologous CD34-Positive Cells for Critical Limb Ischemia
Status: COMPLETED
Conditions: Peripheral Artery Disease|Peripheral Vascular Disease|Critical Limb Ischemia
Interventions: BIOLOGICAL: CD34-positive cells|BIOLOGICAL: CD34-positive cells|BIOLOGICAL: Saline and 5% autologous plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: New Combination of Chemoimmunotherapy for Systemic B-cell Lymphoma With Central Nervous System Involvement
Status: COMPLETED
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: Methotrexate|DRUG: Rituximab|DRUG: Cytarabine|DRUG: Thiotepa|DRUG: liposomial cytarabine|DRUG: Etoposide|DRUG: Ifosfamide|DRUG: Carmustine|RADIATION: whole brain radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pragmatic Posterior Capsular Stretch
Status: COMPLETED
Conditions: Shoulder Impingement|Shoulder Pain|Adhesive Capsulitis|Rotator Cuff Tears|Posterior Capsule Tear|Glenohumeral Subluxation|Glenohumeral Dysplasia|Acromioclavicular; Sprain (Strain)|Internal Rotation Contracture-shoulder|External Rotation Contracture-Shoulder|Flexion Contracture|Extension Contracture-Shoulder
Interventions: OTHER: pragmatic posterior capsular stretch|OTHER: cross body stretch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoveil® Versus TachoSil® for the Treatment of Pulmonary Air Leaks Following Lung Operation
Status: COMPLETED
Conditions: Prolonged Air Leak|Postoperative Air Leak
Interventions: OTHER: TachoSil®|OTHER: Neoveil®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: The Irrigation Or No Irrigation In Simple Lacerations Trials
Status: UNKNOWN
Conditions: Laceration - Injury|Infection
Interventions: PROCEDURE: Irrigation|PROCEDURE: No irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dynamic Combination Therapy on Chinese Herbal Granules to Improve the Symptoms in Convalescent Phase of Ischemic Stroke
Status: COMPLETED
Conditions: Ischemic Stroke|Convalescence
Interventions: DRUG: Dynamic Chinese herbal granule formula|DRUG: Placebo|PROCEDURE: Standard medical care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sampling of Human Microbiota in Order to Test, on a Mouse Model, Individualized Intervention Strategies During Aging
Status: COMPLETED
Conditions: Healthy Volunteers|Frail Volunteers
Interventions: GENETIC: Stool collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of a Hypochlorous Acid Spray Solution in the Treatment of COVID-19 Patients : COVICONTROL Study .
Status: RECRUITING
Conditions: SARS CoV 2 Infection
Interventions: OTHER: Spray with Hypochlorous Acid Group|OTHER: Spray with Placebo Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DLAAG in the Treatment of Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome With Blast Excess
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: Decitabine|DRUG: Cytarabine|DRUG: All-transretinoic acid|DRUG: G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modulation of Sense of Agency With Non-invasive Brain Stimulation and Mindfulness-based Stress Reduction Therapy
Status: RECRUITING
Conditions: Functional Neurological Symptom Disorder|Neurological Diseases or Conditions
Interventions: BEHAVIORAL: Mindfulness-based stress reduction therapy|DEVICE: Inhibitory TMS|BEHAVIORAL: Psychoeducation|DEVICE: TMS sham|DEVICE: Excitatory TMS|DEVICE: Virtual Reality|BEHAVIORAL: Neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Recorded Maternal Voice on the Emergence of General Anesthesia on Pediatric Patients
Status: COMPLETED
Conditions: Anesthesia, General
Interventions: PROCEDURE: recorded maternal voice|PROCEDURE: recorded stranger's voice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Bioavailability of the Test Formulation of Amlodipine 10 mg Tablets (Torrent Pharmaceuticals Limited) Compared to a 10 mg Dose of Norvasc® (Pfizer) in 18 Fed, Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Amlodipine Besylate|DRUG: Norvasc
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Personalized rTMS for Resistant Depression
Status: TERMINATED
Conditions: Depressive Disorder|Treatment-Resistant
Interventions: PROCEDURE: Functional magnetic resonance imaging used to individualize rTMS protocol|DEVICE: Individualized rTMS (transcranial magnetic stimulation)|DEVICE: Classical rTMS (transcranial magnetic stimulation)|DEVICE: Classical tDCS (transcranial direct current stimulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Intended Use Study of the BD SurePath Plus™ Pap
Status: TERMINATED
Conditions: Uterine Cervical Neoplasms|Uterine Cervical Cancer|Neoplasms, Squamous Cell|Neoplasms, Glandular and Epithelial|Neoplasms by Histologic Type|Neoplasms|Papilloma
Interventions: DEVICE: BD SurePath Plus Pap test|DEVICE: BD SurePath Pap test|PROCEDURE: colposcopy with biopsy/ECC|DEVICE: HPV DNA test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Toripalimab Combined With Gemcitabine/5--fluoropyrimidine for Advanced Cholangiocarcinoma
Status: UNKNOWN
Conditions: Advanced Cholangiocarcinoma
Interventions: DRUG: Toripalimab|DRUG: Gemcitabine|DRUG: 5- fluorine pyrimidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Muscle Strengthening Associated With Neuromuscular Stimulus in Patients With Patellofemoral Pain During Negotiating Stairs
Status: UNKNOWN
Conditions: Patellofemoral Pain Syndrome
Interventions: OTHER: Neuromuscular training|OTHER: Muscle strengthening|DEVICE: Sensorimotor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of the Tumor Molecular Profile (CMS), UGT1A1 Genotype and Beta-glucuronidase Activity of the Intestinal Microbiota for Treatment Efficiency, Toxicity, Survival and Quality of Life in Patients With Metastatic or Unresectable Colorectal Cancer During Irinotecan-based Systemic Treatment
Status: RECRUITING
Conditions: Colorectal Neoplasms
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nigella Sativa Oil Extract and Xenograft Bone Graft in Treatment of Infra-bony Defects
Status: UNKNOWN
Conditions: Localized Aggressive Periodontitis
Interventions: PROCEDURE: periodontal regenerative surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Crizanlizumab for Treatment of Retinal Vasculopathy With Cerebral Leukoencephalopathy (RVCL)
Status: ACTIVE_NOT_RECRUITING
Conditions: RVCL - Retinal Vasculopathy Cerebral Leukoencephalopathy
Interventions: DRUG: Crizanlizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Needs-tailored Nurse-led Recovery Program for Community-dwelling People With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Recovery|Medication Adherence
Interventions: BEHAVIORAL: needs-tailored nurse-led recovery program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Efficacy of PRP and Dry Needling in Management of Trigger Points in Masseter Muscle in MPS Patients
Status: UNKNOWN
Conditions: Myofascial Pain Syndrome
Interventions: PROCEDURE: PRP injection|PROCEDURE: Dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET-detected Myocardial Inflammation is a Characteristic of Cardiac Sarcoid But Not of ARVC
Status: UNKNOWN
Conditions: Sarcoidosis|Arrhythmogenic Right Ventricular Cardiomyopathy
Interventions: RADIATION: PET CT|OTHER: Cardiac MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Ewing Sarcoma|Solid Tumors|Rhabdoid Tumor|Rhabdomyosarcoma|Neuroblastoma|Medulloblastoma|Diffuse Intrinsic Pontine Glioma
Interventions: DRUG: Palbociclib|DRUG: Temozolomide|DRUG: Irinotecan|DRUG: Topotecan|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: European All-comers' Multicentric Prospective REGISTRY on LUMINOR© Drug Eluting Balloon in the Superficial Femoral Artery and Popliteal Artery With 5 Years Follow-up.
Status: RECRUITING
Conditions: Angioplasty|Peripheral Arterial Disease|Drug-eluting Balloon|Femoral Artery|Paclitaxel
Interventions: DEVICE: LUMINOR© Paclitaxel eluting balloon
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Gene Transfer Single Dose Study to Evaluate the Safety, Tolerability and Efficacy of SRP-9003 in Non-Ambulatory and Ambulatory Participants With Limb Girdle Muscular Dystrophy, Type 2E/R4 (Beta-Sarcoglycan [β-SG] Deficiency)
Status: ACTIVE_NOT_RECRUITING
Conditions: Limb Girdle Muscular Dystrophy
Interventions: GENETIC: SRP-9003
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Immune Response of Novartis Meningococcal ACWY Conjugate Vaccine In Adolescents
Status: COMPLETED
Conditions: Meningococcal Meningitis|Human Papillomavirus Infection|Pertussis|Tetanus
Interventions: BIOLOGICAL: Novartis Meningococcal ACWY Conjugate Vaccine|BIOLOGICAL: Tdap Vaccine|BIOLOGICAL: Novartis Meningococcal ACWY Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dual-target CAR-T Cells (C-4-29) in the Treatment of Relapsed/Refractory Multiple Myeloma
Status: ENROLLING_BY_INVITATION
Conditions: Multiple Myeloma in Relapse|Multiple Myeloma, Refractory
Interventions: BIOLOGICAL: C-4-29 Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-blind, Placebo-controlled Study of BGC20-1531 in Migraine
Status: WITHDRAWN
Conditions: Migraine
Interventions: DRUG: BGC20-1531|DRUG: Lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Stroke Volume Optimization of Goal Directed Fluid Therapy During Radical Cystectomy
Status: COMPLETED
Conditions: Radical Cystectomy
Interventions: OTHER: stroke volume optimization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of ECPP on Recurrent Bile Duct Stones
Status: RECRUITING
Conditions: Sphincterotomy, Endoscopic
Interventions: PROCEDURE: EST|PROCEDURE: ECPP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Emotional Awareness and Expression Therapy (EAET) or Cognitive Behavior Therapy (CBT) for Older Veterans With Chronic Musculoskeletal Pain
Status: COMPLETED
Conditions: Musculoskeletal Pain
Interventions: BEHAVIORAL: Emotional Awareness and Expression Therapy|BEHAVIORAL: Cognitive Behavior Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GA/Spinal vs. GA/Spinal/NMB for Operative Repair of Hip Fracture
Status: WITHDRAWN
Conditions: Hip Fractures|Anesthesia, Spinal|Anesthesia, General|Neuromuscular Blockade
Interventions: DRUG: Rocuronium|DRUG: Sugammadex|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison Between Neurostimulation and Loss of Resistance for Cervical Paravertebral Blocks
Status: UNKNOWN
Conditions: Shoulder Surgery
Interventions: OTHER: Nerve stimulation|OTHER: Loss of resistance to air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study to Assess the Effects of Repeat Doses of Fluticasone Furoate and GW642444M Combination in Healthy Subjects and in Subjects With Severe Impairment.
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Inhaled FF/ GW642444M (200/25mcg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combined Use of Angiography, Optical Coherence Tomography and Intravascular Ultrasound in Evaluation of Pulmonary Vascular Structure and Function in Patients With Pulmonary Arterial Hypertension Treated With Oral Bosentan
Status: WITHDRAWN
Conditions: Pulmonary Arterial Hypertension
Interventions: DEVICE: St Jude Medical C7 Dragonfly Optical Coherence Tomography (OCT)|DEVICE: Boston Scientific Intravascular Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Trial Evaluating OPC-34712 in Subjects With Normal Renal Function and Renally Impaired Subjects
Status: COMPLETED
Conditions: Schizophrenia|Psychiatric Disorders
Interventions: DRUG: OPC-34712
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Pre-spinal Atropine on Post Spinal Hemodynamics and Cardiac Output Measured by Electrical Cardiometry in Caesarean Delivery
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: atropine|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety in Patients With Type 2 Diabetes Mellitus, Cardiovascular Disease and Hypertension
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Cardiovascular Disease|Hypertension|Inadequate Glycaemic Control
Interventions: DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Factors Affecting the Effective End-tidal Concentration of Desflurane Anaesthesia
Status: COMPLETED
Conditions: General Anesthetic Drug Adverse Reaction
Interventions: DRUG: desflurane - oxygen in air|DRUG: desflurane - oxygen in nitric oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Improving Alcohol and Substance Use Care Access, Outcome, Equity During the Reproductive Years
Status: SUSPENDED
Conditions: Alcohol-Related Disorders|Substance-Related Disorders|Mental Health|Reproductive Health|Sexual Health|Sexually Transmitted Diseases|Contraception|Maternal Health|Pregnancy|Women's Health
Interventions: BEHAVIORAL: Screening, Brief Intervention, and Referral to Treatment (SBIRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Postoperative Ferric Carboxymaltose
Status: UNKNOWN
Conditions: Postoperative Anemia|Knee Osteoarthritis|Total Knee Arthroplasty
Interventions: DRUG: Ferric carboxymaltose|DRUG: 0.9% Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Abuse Potential of Tozadenant Relative to D-Amphetamine and Placebo When Administered Orally in Healthy, Non-Dependent, Recreational Polydrug Users
Status: TERMINATED
Conditions: Abuse Potential
Interventions: DRUG: Tozadenant|DRUG: Placebo oral tablet|DRUG: d-amphetamine|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Sphenopalatine Ganglion Block for the Treatment of Post-Stroke Headache
Status: UNKNOWN
Conditions: Headache|Stroke|Ischemic Stroke
Interventions: DRUG: Liquid Lidocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Transthyretin Cardiac Amyloidosis in Clinically Significant Aortic Stenosis
Status: COMPLETED
Conditions: Aortic Stenosis|Transthyretin Amyloidosis|Transthyretin Amyloid Cardiomyopathy|Transthyretin Cardiac Amyloidosis
Interventions: DRUG: 99mTc-PYP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Epidemiology and Control of Mansonella Perstans Infection in Uganda
Status: COMPLETED
Conditions: Mansonelliasis|Pruritus|Lymphoedema|Abdominal Pains
Interventions: DRUG: ivermectin and albendazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Monocenter, Open Label Clinical Investigation on the Treatment of Radiation Induced Dermatitis With Xonrid®
Status: COMPLETED
Conditions: Radiodermatitis|Quality of Life
Interventions: DEVICE: Xonrid® gel|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate Efficacy and Safety of Oxycodone/Naloxone Compared to OxyContin in Korean Cancer Patients
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Oxycodone/Naloxone|DRUG: Oxycodone(single compound)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Use of Ivabradine in Heart Failure
Status: UNKNOWN
Conditions: Heart Failure With Reduced Ejection Fraction|Decompensated Heart Failure
Interventions: DRUG: Ivabradine|DRUG: Bisoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examine the Effects of Mindfulness in Woman With a History of Child Adversity
Status: COMPLETED
Conditions: Stress|Psychological Stress|Child Maltreatment|Depressive Symptoms|Signs and Symptoms
Interventions: BEHAVIORAL: Mindfulness and compassion-based practices; approximately 5-10 minutes two times/day|BEHAVIORAL: Mindful awareness and reporting of current thoughts and feelings, 2 times/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Efficacy and Safety Study of Protoxin Versus Botox® in Subjects With Moderate to Severe Glabellar Lines
Status: COMPLETED
Conditions: Glabellar Frown Lines
Interventions: BIOLOGICAL: PROTOXIN|BIOLOGICAL: Botox®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Evaluation of a Novel Multi-Wavelength Laser for Benign Pigmented Lesion Removal
Status: COMPLETED
Conditions: Pigmented Skin Lesion of Suspected Benign Nature
Interventions: DEVICE: Investigational Enlighten Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Cytotoxic T Cells Augmenting Autologous Hematopoietic Stem Cell (AHSC) Transplantation for Acute Myeloid Leukemia (AML)
Status: TERMINATED
Conditions: AML
Interventions: BIOLOGICAL: AMLCTL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Biomimetic Hydroxyapatite in the Treatment of Molar Incisor Hypomineralization.
Status: COMPLETED
Conditions: Molar Incisor Hypomineralization
Interventions: OTHER: Biorepair Shock Treatment|OTHER: No treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About the Awareness and Knowledge That Doctors Have About the Safety and Safe Use Information for Androcur and Other Cyproterone Acetate Treatments in Europe
Status: COMPLETED
Conditions: Signs of Androgenisation in Women, e.g. Hirsutism, Androgenetic Alopecia, Acne and Seborrhea|Hypersexuality in Men|Sexual Deviations in Men|Prostate Cancer
Interventions: DRUG: Cyproterone Acetate (Androcur, BAY94-8367)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluate Safety and Efficacy of Intravenous Autologous ADMSc for Treatment of Idiopathic Pulmonary Fibrosis
Status: UNKNOWN
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: BIOLOGICAL: Autologous Stromal Vascular Fraction (SVF)|BIOLOGICAL: Autologous Adipose Derived MSCs (ADMSCs)|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of SAAE on Ventricular Remodeling in PA Patients
Status: RECRUITING
Conditions: Primary Aldosteronism
Interventions: OTHER: Super selective adrenal artery embolization|DRUG: Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intravenous EACA on Blood Loss and Transfusion Requirements After Bilateral VRO
Status: COMPLETED
Conditions: E-Aminocaproic Acid|Bilateral Varus Rotational Osteotomy
Interventions: DRUG: E-Aminocaproic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alleviation of Common Cold Symptoms
Status: COMPLETED
Conditions: Common Cold|Pharyngitis|Fever|Congestion|Rhinorrhea|Cough|Sore-throat|Sore Throats Viral|Malaise|Headache|Runny Nose|Sneezing
Interventions: DRUG: Wintergreen Throat Spray and Aspirin Tablet|DRUG: Aspirin Throat Spray and Placebo Tablet|DIETARY_SUPPLEMENT: Wintergreen Throat Spray and Placebo Tablet|OTHER: Placebo Throat Spray and Placebo Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Clogged Tympanostomy Tubes: An Off-Label Use of Dornase Alfa (Pulmozyme®)
Status: COMPLETED
Conditions: Otitis Media
Interventions: DRUG: dornase alfa (Pulmozyme®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis
Status: COMPLETED
Conditions: Pregnancy
Interventions: DRUG: Clindamycin|DRUG: Placebo|DRUG: Clindamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pain Relief Study of Ultrasound Guided Transverse Abdominis Plane(TAP)Block
Status: WITHDRAWN
Conditions: Cesarean Section
Interventions: DRUG: 0.5% ropivacaine|DRUG: 0.9% sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Desogestrel for Endometriosis Related Pain
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: Desogestrel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of OSE-127 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: OSE-127|DRUG: Placebo|DRUG: OSE-127
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Bone-void Filler on Anterior Knee Pain Following ACL Reconstruction
Status: COMPLETED
Conditions: ACL
Interventions: DEVICE: DBM|DEVICE: Calcium phosphate cement|OTHER: Autologous bone graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In Patients With Carpal Tunnel Syndrome, Median Nerve Conduction is Evaluated After Moving the Wrist Bones
Status: RECRUITING
Conditions: Carpal Tunnel Syndrome
Interventions: OTHER: Manual mobilization of the carpal bones.|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Use of Trastuzumab to Induce Increased ER Expression in ER-negative/Low, Her-2/Neu Positive Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: trastuzumab (Herceptin®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxidative Stress Expression and Metabolic Imbalance in Critically Ill Polytrauma Patients and the Implications of Antioxidant Therapy on Clinical Outcomes
Status: UNKNOWN
Conditions: Oxidative Stress|Polytrauma
Interventions: DRUG: Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparative Efficacy of CUS, CXR and CAD in TB Diagnosis in LMIC
Status: NOT_YET_RECRUITING
Conditions: Tuberculosis, Pulmonary
Interventions: DIAGNOSTIC_TEST: Comparative analysis of CUS, CAD and CXR in pulmonary TB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pegylated Liposomal Doxorubicin Hydrochloride, Carboplatin, Veliparib, and Bevacizumab in Treating Patients With Recurrent Ovarian Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer
Status: COMPLETED
Conditions: Ovarian Clear Cell Cystadenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Seromucinous Carcinoma|Ovarian Serous Cystadenocarcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Undifferentiated Ovarian Carcinoma
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Carboplatin|OTHER: Laboratory Biomarker Analysis|DRUG: Pegylated Liposomal Doxorubicin Hydrochloride|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Balance of Angiotensin II Receptors in Vessel Function After Preeclampsia
Status: RECRUITING
Conditions: Preeclampsia
Interventions: DRUG: Compound 21|DRUG: Angiotensin II
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vida Sana y Completa Obesity and Food Insecurity Study
Status: RECRUITING
Conditions: Obesity
Interventions: BEHAVIORAL: Vida Sana|BEHAVIORAL: Vida Sana y Completa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Fractionated 1927nm Laser for Hyperpigmentation in Fitzpatrick Skin Phototypes V and VI
Status: ACTIVE_NOT_RECRUITING
Conditions: Hyperpigmentation
Interventions: DEVICE: MOXI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect and Safety of Different Intensity Anticoagulation Therapy in Elderly Patients With Non-valvular Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Warfarin|DRUG: aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Efficacy of 24 Weeks Simeprevir+Sofosbuvir for Chronic Hepatitis C Genotype 1
Status: WITHDRAWN
Conditions: PT-NANBH
Interventions: DRUG: Simeprevir|DRUG: Sofosbuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study of the Nativis Voyager® System in Patients With Recurrent Glioblastoma Multiforme (GBM)
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: DEVICE: Nativis Voyager RFE Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metacognitive and Insight Therapy for Persons With Schizophrenia (RCT MERIT)
Status: UNKNOWN
Conditions: Diagnosis of Schizophrenia Spectrum Disorders
Interventions: BEHAVIORAL: MERIT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety/Efficacy Trial of Killed Leishmania Vaccine in Volunteers With Positive Response to Leishmanin (LST>0)
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Alum-ALM + BCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Targeted Polymeric Nanoparticles Loaded With Cetuximab and Decorated With Somatostatin Analogue to Colon Cancer
Status: UNKNOWN
Conditions: Colon Cancer|Colo-rectal Cancer
Interventions: DRUG: Cetuximab nanoparticles|DRUG: Oral approved anticancer drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Development of a Risk Prediction Algorithm Through the Investigation of Genetic Risk Factors and the Complexity of Coronary Artery Disease to Estimate Future Risk of Cardiovascular Events: Angiographic (SYNTAX Score), Clinical and Pharmacogenetic Analysis.
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: GENETIC: SNPs associated with CAD, SNPs associated with pharmacological response to clopidogrel and statins
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Diagnose Lung Cancer by Sputum Cytology (01-312)
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Uridine 5'-Triphosphate (UTP) Solution for Inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pain Associated With the Removal of Wound Dressing During Care of Venous Leg Ulcer. Comparison of the Efficacy and Safety of Two Dressings Urgotul and TulleGras
Status: COMPLETED
Conditions: Venous Leg Ulcer
Interventions: DEVICE: Urgotul|DEVICE: TulleGras M.S.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT