pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase I Study for Autologous Dermal Substitutes and Dermo-epidermal Skin Substitutes for Treatment of Skin Defects
Status: COMPLETED
Conditions: Burn Injury|Soft Tissue Injury|Skin Necrosis|Scars|Congenital Giant Nevus|Skin Tumors
Interventions: BIOLOGICAL: denovoDerm|BIOLOGICAL: denovoSkin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of the Efficacy & Safety of Natural Eggshell Membrane (NEM) for Joint & Connective Tissue Disorders
Status: COMPLETED
Conditions: Osteoarthritis|Fibromyalgia
Interventions: DIETARY_SUPPLEMENT: NEM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Different Types of Surgery in Treating Patients With Stage IA Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer
Interventions: PROCEDURE: lobectomy|PROCEDURE: segmentectomy or wedge resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clonidine for Tourniquet-related Pain in Children
Status: UNKNOWN
Conditions: Polydactyly Toe|Thumb Hypoplasia|Trigger Finger|Polydactyly; Fingers|Osteomyelitis of Hindfoot|Osteomyelitis of Midfoot|Congenital Talipes Equinovarus|Congenital Talipes Calcaneus|Tarsal Coalition|Club Foot|Clubfoot|Congenital Knee Deformity|Leg Length Inequality in Children|Flatfoot|Hollow Foot|Congenital Valgus Foot Deformity|Polydactylia|Polysyndactyly|Syndactyly|Thumb Aplasia|Congenital Hand and Foot Deformity|Subungual Exostosis|Finger Deformity|Toe Deformity|Osteomyelitis of the Foot|Calcaneus Deformity of Foot|Congenital Hand Deformity|Hand Deformities, Congenital|Valgus Foot Deformity|Toe Joint Deformity|Capsulitis of MTP Joint
Interventions: DRUG: Catapresan|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ramipril 10 mg Capsule in Healthy Subjects Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ramipril 10 mg capsule|DRUG: Altace® 10 mg capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Fluid Resuscitation With HES 200/0.5 10% in Severe Burn Injury
Status: COMPLETED
Conditions: Survival|Renal Failure
Interventions: DRUG: fluid resuscitation|DRUG: Fluid resuscitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOLFOX/Bevacizumab/Hydroxychloroquine (HCQ) in Colorectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer|Colon Cancer|Metastasis|Adenocarcinoma
Interventions: DRUG: Hydroxychloroquine|DRUG: Oxaliplatin|DRUG: Leucovorin|DRUG: 5-fluorouracil|DRUG: 5-fluorouracil|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: 3D Evaluation of Postoperative Edema After Third Molar Surgery
Status: RECRUITING
Conditions: Molar, Third|Third Molar Surgery|Soft Tissue Swelling|Pain, Postoperative|Quality of Life
Interventions: DRUG: Combination of corticosteroid (methylprednisolone - Medrol, 16mg Pfizer Laboratories) therapy and non-steroidal anti-inflammatory (Ibuprofen 600mg Mylan) therapy|DRUG: Non-steroidal anti-inflammatory therapy (Ibuprofen 600mg Mylan)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Frozen Versus Refrigerated MMRV (Combined Measles, Mumps, Rubella, and Varicella) Investigational Vaccine (V221-016)
Status: COMPLETED
Conditions: Measles|Mumps|Rubella|Varicella
Interventions: BIOLOGICAL: V221, measles, mumps, rubella and varicella (Oka/Merck) virus vaccine live / Duration of Treatment: 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of the Safety & Efficacy of Two Docetaxel-Based Regimens Plus Bevacizumab for the Adjuvant Treatment of Subjects With Node Positive or High Risk Node Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Docetaxel|DRUG: Doxorubicin|DRUG: Carboplatin|DRUG: Cyclophosphamide|DRUG: Trastuzumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy of Gefapixant (MK-7264/AF-219), in Participants With Chronic Cough (MK-7264-006)
Status: COMPLETED
Conditions: Chronic Cough
Interventions: DRUG: Gefapixant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pupillometry Techniques Usage to Quantify the Programming Parameters Effect in the Auditory Effort in Zti Opticon Cochlear Implant Adult Users
Status: UNKNOWN
Conditions: Bilateral Sensorineural Hearing Loss|Unilateral Sensorineural Hearing Loss
Interventions: DEVICE: Neuro Zti cochlear implant and Neuro 2 sound processor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of Ra-223 Dichloride in Combination With Hormonal Therapy and Denosumab in the Treatment of Patients With Hormone-Positive Bone-Dominant Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Ra-223 dichloride|DRUG: Denosumab|DRUG: Hormone Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of L19TNF in Patients With Isocitrate Dehydrogenase (IDH) Wildtype WHO Grade III / IV Glioma at First Relapse
Status: COMPLETED
Conditions: Glioma of Brain
Interventions: DRUG: L19TNF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Two Preparations of Loratadine + Pseudoephedrine in Patients With Perennial Allergic Rhinitis.
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis
Interventions: DRUG: Cloratadd-D|DRUG: Allegra-D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study the Effect of Water Kefir Consumption on the Gut Microbiome in Healthy Adults
Status: RECRUITING
Conditions: Healthy Diet|Gastrointestinal Microbiome|Probiotics
Interventions: DIETARY_SUPPLEMENT: Water Kefir beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Stress Management Therapy in Patients Receiving Chemotherapy for Cancer
Status: COMPLETED
Conditions: Cancer|Psychological Stress|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: OTHER: Self Administered Stress Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Mono-center Study in Healthy Volunteers on the Comparative Bioavailability of Pletal 100 mg Tablets and a New Pletal 100 mg Orodispersible Tablet (ODT), This Latter in Fasting Conditions With and Without Water and Under Fed Conditions
Status: COMPLETED
Conditions: Intermittent Claudication
Interventions: DRUG: Cilostazol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DAHANCA 25B: Progressive Resistance Training as Intervention for Regaining Muscle Mass After Radiation Therapy in Patients With HNSCC
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: OTHER: Progressive Resistance Exercise Training|OTHER: Progressive Resistance Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: GDF15 Based TPF Induction Chemotherapy for OSCC Patients
Status: RECRUITING
Conditions: Mouth Neoplasms|Carcinoma, Squamous Cell
Interventions: DRUG: TPF induction chemotherapy|PROCEDURE: surgery group|RADIATION: Post-operative radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Ziprasidone in Children and Adolescents With Bipolar I Disorder (Manic or Mixed)
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Ziprasidone oral capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Placebo Controlled, Clinical Trial Designed to Assess the Efficacy, Safety and Dose Response Characterisation of STS01 for the Treatment of Mild-moderate Alopecia Areata (AA)
Status: COMPLETED
Conditions: Alopecia Areata
Interventions: DRUG: STS01|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Immediate v. Delayed CT/NG Test for Treatment in the ED
Status: COMPLETED
Conditions: Reproductive Tract Infections
Interventions: DEVICE: Roche AMPLICOR CT/NG|DEVICE: Cepheid Xpert CT/NG Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: BDB001-102: Open Label Dose Escalation of BDB001 in Combination w Atezolizumab
Status: ACTIVE_NOT_RECRUITING
Conditions: Tumor, Solid
Interventions: DRUG: BDB001|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgery to Remove Sentinel Lymph Nodes With or Without Removing Lymph Nodes in the Armpit in Treating Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: conventional surgery|PROCEDURE: Sentinel node resection followed by node examination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study and Preliminary Efficacy of Infusion Haploidentical Mesenchymal Stem Cells Derived From Bone Marrow for Treating Recessive Dystrophic Epidermolysis Bullosa
Status: UNKNOWN
Conditions: Epidermolysis Bullosa Dystrophica, Recessive
Interventions: BIOLOGICAL: mesenchymal stem cells derived from bone marrow (BM-MSCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ctDNA as a Assisted Diagnosis, Early Intervention and Prognostic Marker for Peritoneal Metastases From Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer|Peritoneal Metastases
Interventions: DIAGNOSTIC_TEST: ctDNA monitoring|DIAGNOSTIC_TEST: Imageology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment With Apixaban Versus Warfarin in Patients With Left Ventricular Thrombus After Acute Myocardial Infarction
Status: NOT_YET_RECRUITING
Conditions: Left Ventricular Thrombus|Acute Myocardial Infarction
Interventions: DRUG: Apixaban|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Immunogenicity & Safety of 2 Different Formulations of Human Rotavirus (HRV) Vaccine for the Prophylaxis of Rotavirus Gastroenteritis
Status: COMPLETED
Conditions: Infections, Rotavirus
Interventions: BIOLOGICAL: Live attenuated rotavirus vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial Testing Root Coverage With Acellular Dermal Matrix in Thin and Thick Gingival Biotypes
Status: ACTIVE_NOT_RECRUITING
Conditions: Gingival Recession
Interventions: BIOLOGICAL: Acellular Dermal Matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab and M032 (NSC 733972)
Status: RECRUITING
Conditions: Glioblastoma Multiforme|Anaplastic Astrocytoma|Gliosarcoma
Interventions: DRUG: M032|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy With or Without Radiation Therapy for Metastatic Urothelial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Urothelial Carcinoma|Platinum-Resistant Urothelial Carcinoma|Stage IV Bladder Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Pembrolizumab|PROCEDURE: Positron Emission Tomography|OTHER: Questionnaire Administration|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Colostrum Supplements Effect on the Physical Performance and Cognitive Function
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Colostrum Capsule 500 mg (Colostrum® 500 mg Veg Capsules, nowfoods®, Illinois, USA)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Use of Passive, Adaptive, and Active Prosthetic Knees in Persons With Unilateral, Transfemoral Amputation
Status: COMPLETED
Conditions: Transfemoral Amputation
Interventions: DEVICE: Active knee (Ossur Power Knee II)|DEVICE: Adaptive knee (Ossur Rheo)|DEVICE: Passive knee (Various manufacturers)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Injection Site Study In Patients With Type 2 Diabetes Mellitus (T2DM) And Healthy Volunteers
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: GSK716155 subcutaneous injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: mFOLFIRINOX With or Without Stereotactic Body Radiotherapy in Locally Advanced Pancreatic Adenocarcinoma
Status: RECRUITING
Conditions: Pancreatic Adenocarcinoma|Pancreatic Cancer Non-resectable
Interventions: RADIATION: SBRT+mFOLFIRINOX|DRUG: mFOLFIRINOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Steroid Therapy in Vestibular Neuritis
Status: COMPLETED
Conditions: Vestibular Neuritis
Interventions: DRUG: Ginkgo biloba & Methylprednisolone|DRUG: Ginkgo biloba
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mitochondrial Capacity Boost in ALS (MICABO-ALS) Trial
Status: UNKNOWN
Conditions: Amyotrophic Lateral Sclerosis (ALS)
Interventions: COMBINATION_PRODUCT: Antioxidants
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Encorafenib, Binimetinib, and Nivolumab in Treating Microsatellite Stable BRAF V600E Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Metastatic Colon Adenocarcinoma|Metastatic Colorectal Adenocarcinoma|Metastatic Microsatellite Stable Colorectal Carcinoma|Metastatic Rectal Adenocarcinoma|Stage III Colon Cancer|Stage III Colorectal Cancer|Stage III Rectal Cancer|Stage IIIA Colon Cancer|Stage IIIA Colorectal Cancer|Stage IIIA Rectal Cancer|Stage IIIB Colon Cancer|Stage IIIB Colorectal Cancer|Stage IIIB Rectal Cancer|Stage IIIC Colon Cancer|Stage IIIC Colorectal Cancer|Stage IIIC Rectal Cancer|Stage IV Colon Cancer|Stage IV Colorectal Cancer|Stage IV Rectal Cancer|Stage IVA Colon Cancer|Stage IVA Colorectal Cancer|Stage IVA Rectal Cancer|Stage IVB Colon Cancer|Stage IVB Colorectal Cancer|Stage IVB Rectal Cancer|Stage IVC Colon Cancer|Stage IVC Colorectal Cancer|Stage IVC Rectal Cancer
Interventions: DRUG: Binimetinib|DRUG: Encorafenib|BIOLOGICAL: Nivolumab|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Hand-foot Skin Reaction
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: OTHER: best support care|OTHER: moisture cream|OTHER: 10% urea-based cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Sirolimus in Combination With Metronomic Chemotherapy in Children With High-Risk Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: Sirolimus|DRUG: Cyclophosphamide|DRUG: Etoposide|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effect of Hydroxychloroquine on Immunoglobulin A (IgA) Nephropathy Course QUIgAN Study
Status: NOT_YET_RECRUITING
Conditions: IgA Nephropathy
Interventions: DRUG: Hydroxychloroquine Oral Tablet|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tracking Response to Antidepressants in Advance of Investigational Trials, Relapse Study
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: FDA-approved selective-serotonin reuptake inhibitors (SSRIs) and selective-norepinephrine reuptake inhibitors (SNRIs)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mesenchymal Stromal Cells to Treat Type 1 Diabetes in Children and Adolescents
Status: RECRUITING
Conditions: Type1diabetes
Interventions: BIOLOGICAL: the ATMP Protrans
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of TAK-164 in Participants With Advanced Gastrointestinal (GI) Cancer Expressing Guanylyl Cyclase C (GCC)
Status: TERMINATED
Conditions: Gastrointestinal Neoplasms; Esophageal, Stomach, Pancreas, Colon Neoplasms; Malignant Tumors of Digestive Organ; Advanced Gastrointestinal Malignancies
Interventions: DRUG: TAK-164|DRUG: 89Zr-TAK-164
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Use of New Generation Fetoscopes in Pregnancies Affected by Fetal Diseases Amenable to Fetoscopy Therapy
Status: RECRUITING
Conditions: In Utero Procedure Affecting Fetus or Newborn
Interventions: DEVICE: Karl Storz New Generation Fetoscope - curved 11508AAK|DEVICE: Karl Storz New Generation Fetoscope - straight 11506AAK
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Pulmonary Recruitment Maneuver (PRM) on Pain and Nausea After Laparoscopic Bariatric Surgery
Status: COMPLETED
Conditions: Pain, Postoperative|Postoperative Nausea and Vomiting
Interventions: PROCEDURE: Pulmonary recruitment maneuver|PROCEDURE: Laparoscopic bariatric surgery|DEVICE: Ventilator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Carfilzomib Plus Belinostat in Relapsed/Refractory NHL
Status: COMPLETED
Conditions: Non-Hodgkin Lymphoma|Diffuse Large B-cell Lymphoma|Mantle Cell Lymphoma|Follicular Lymphoma|Peripheral T-cell Lymphoma
Interventions: DRUG: Carfilzomib|DRUG: Belinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Erector Spinae Block for Post Analgesia in Pediatric Patients
Status: COMPLETED
Conditions: Pediatric Cancer
Interventions: DRUG: Bupivacaine Hydrochloride|DRUG: Tramadol hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Improving Antihypertensive and Lipid-Lowering Therapy
Status: UNKNOWN
Conditions: Hyperlipidemia|Hypertension
Interventions: OTHER: Clinical Decision Support for Hypertension|OTHER: Automated Telephone Outreach for Antihypertensive Therapy|OTHER: Clinical Decision Support for Lipid-lowering Therapy|OTHER: Automated Telephone Outreach for Lipid-lowering Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Pain Associated With Fibromyalgia
Status: COMPLETED
Conditions: Pain Associated With Fibromyalgia
Interventions: DRUG: DS-5565|DRUG: Pregabalin|DRUG: Placebo tablet|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Buccal Mucosal Graft for the Repair of Iatrogenic Pelviureteric Junction Obstruction or Ureteric Stricture.
Status: UNKNOWN
Conditions: Pelvi Ureteric Junction Obstruction or Ureteral Stricture
Interventions: PROCEDURE: buccal mucosal graft to repair iatrogenic PUJO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pragmatic Randomized Clinical Trial to Limit Weight Gain in Pregnancy and Prevent Obesity
Status: RECRUITING
Conditions: Pregnancy Weight Gain|Postpartum Weight Retention|Childhood Obesity|Gestational Diabetes|Overweight and Obesity
Interventions: BEHAVIORAL: Healthy for Two/Healthy for You
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Mechanisms of Lung Defense and Their Relationship With Airway Infection in Chronic Obstructive Pulmonary Disease (COPD)
Status: UNKNOWN
Conditions: Bacterial Infection in COPD
Interventions: PROCEDURE: Bronchoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fecal Microbiota Transplantation in the Treatment of Major LARS
Status: NOT_YET_RECRUITING
Conditions: Low Anterior Resection Syndrome|Fecal Microbiota Transplantation
Interventions: BIOLOGICAL: fecal microbiota transplantation|DIETARY_SUPPLEMENT: Formulated probiotic supplements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Photobiomodulation Using Low-Level Diode Laser Therapy on Postoperative Pain in Symptomatic Lower Molar Teeth With Irreversible Pulpitis and Apical Periodontitis; a Randomized Controlled Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Effect of Photobiomodulation Using Diode Laser
Interventions: DEVICE: Photobiomodulation by low level diode laser|OTHER: Mock Laser Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ER-One: A Double-blind Trial of Erector Spinae Block (ESP) Versus Paravertebral Block (PVB) Before Breast Cancer Surgery
Status: COMPLETED
Conditions: Breast Surgery
Interventions: DRUG: Ropivacaïne Hydrochloride by Erector Spinae block|DRUG: Ropivacaïne Hydrochloride by Paravertebral block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of DIammine SIlver Fluoride on Tooth Sensitivity
Status: UNKNOWN
Conditions: Dental Sensitivity|Gingival Condition
Interventions: DEVICE: DIammine SIlver fluoride|DEVICE: DIstilled water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of AK104 Plus Anlotinib in NSCLC
Status: UNKNOWN
Conditions: NSCLC
Interventions: DRUG: AK104+anlotinib|DRUG: AK104+anlotinib|DRUG: AK104+anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Clarithromycin Quadruple Therapy
Status: COMPLETED
Conditions: Gastritis|Peptic Ulcer|Dyspepsia
Interventions: DRUG: Berberine|DRUG: clarithromycin|DRUG: Bismuth|DRUG: Lansoprazole|DRUG: amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Fibrinogen Concentrate (FGTW) in Pediatric Patients With Congenital Fibrinogen Deficiency
Status: COMPLETED
Conditions: Hypofibrinogenemia, Congenital|Afibrinogenemia, Congenital
Interventions: DRUG: biological: human fibrinogen concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy of a Probiotic and Postbiotic in Overweight and Obese Individuals
Status: UNKNOWN
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Probiotics|DIETARY_SUPPLEMENT: Postbiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Tolerance of Intra-articular Injection Autologous Stromal Vascular Fraction for the Treatment of Rhizarthrosis
Status: NOT_YET_RECRUITING
Conditions: Rhizarthrosis
Interventions: DRUG: SVF injection into wrist
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PUFAs in Preterm Infants
Status: NOT_YET_RECRUITING
Conditions: Necrotizing Enterocolitis|Intraventricular Hemorrhage|BPD - Bronchopulmonary Dysplasia|Sepsis|Periventricular Leukomalacia|Patent Ductus Arteriosus
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Cobimetinib Administered as Single Agent and in Combination With Venetoclax, With or Without Atezolizumab, in Participants With Relapsed and Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Cobimetinib|DRUG: Venetoclax|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of The Effectiveness of N-Acetylcysteine in Kidney Protection Following Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Heart Disease|Renal Insufficiency
Interventions: DRUG: Intravenous N-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Pembrolizumab With Ataluren in Patients With Metastatic pMMR and dMMR Colorectal Carcinoma or Metastatic dMMR Endometrial Carcinoma: the ATAPEMBRO Study
Status: RECRUITING
Conditions: Colorectal Cancer|Endometrium Cancer
Interventions: DRUG: Ataluren + Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of RO4917838 on Biomarker Measures of Cognitive Dysfunction in Participants With Schizophrenia and Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Placebo|DRUG: RO4917838|DRUG: Standard Antipsychotic Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics for Quality of Life in Autism Spectrum Disorders
Status: COMPLETED
Conditions: Autism Spectrum Disorders|Anxiety
Interventions: DRUG: Maltose (placebo)|DRUG: Visbiome Extra Strength
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Parent Nurse Controlled Analgesic in Pediatric Patients With Developmental Delay
Status: COMPLETED
Conditions: Post Operative Pain
Interventions: OTHER: Pain and standard side effect management for PNCA with basal method.|OTHER: Pain and standard side effect management with PNCA without basal|OTHER: Pain and standard side effect management with IV on an as needed basis method.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effects of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Blepharitis During a Four-Week Treatment Period (P08638)
Status: COMPLETED
Conditions: Blepharitis
Interventions: DRUG: Azithromycin ophthalmic solution, 1%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CBT-I for Cannabis Use
Status: TERMINATED
Conditions: Marijuana Abuse|Sleep Initiation and Maintenance Disorders
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia (CBT-I)|BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia Plus Mobile App (CBT-I-MA)|BEHAVIORAL: Desensitization Treatment for Insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bone Marrow Cell Transplantation to Improve Heart Function in Individuals With End-Stage Heart Failure
Status: TERMINATED
Conditions: Heart Failure, Congestive
Interventions: BIOLOGICAL: Intramyocardial injection of bone marrow mononuclear cells|BIOLOGICAL: Intramyocardial injection of CD34+ selected bone marrow mononuclear cells|DEVICE: LVAD alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proteus Discover in Subjects With Uncontrolled Hypertension and Type 2 Diabetes
Status: COMPLETED
Conditions: Hypertension|Diabetes Mellitus, Type 2|Hypercholesterolemia
Interventions: OTHER: Proteus Discover|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intravenous L-kynurenine (LKYN) on Cerebral Hemodynamics in Healthy Volunteers
Status: COMPLETED
Conditions: Headache
Interventions: DRUG: L-kynurenine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Donor White Blood Cell Infusions and Interleukin-2 in Treating Patients Who Are Undergoing an Autologous Stem Cell Transplant for Relapsed Advanced Lymphoid Cancer
Status: COMPLETED
Conditions: Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: therapeutic allogeneic lymphocytes|DRUG: melphalan|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Tapering From Long-term Opioid Therapy in Chronic Pain Population. Randomized Controlled Trial With 12 Months Follow up
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Pain|Analgesics, Opioid|Opioid Withdrawal|Opioid Use|Substance Use Disorders
Interventions: BEHAVIORAL: Tapering
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Perilla Extract on Improvement on Gastrointestinal Discomfort
Status: COMPLETED
Conditions: Abdominal Pain/ Discomfort|Slightly Constipation
Interventions: DIETARY_SUPPLEMENT: Perilla extract|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy and Radiation Therapy in Treating Patients With Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: fluorouracil|DRUG: gemcitabine hydrochloride|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Vein Reconnection Following Ablation Index-guided Ablation: a Success Evaluation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DEVICE: PVI using ThermoCool® SmartTouch® Catheter|DEVICE: RFA ablation data comparison
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot RCT of a Video-based Intervention for Suicide Prevention
Status: COMPLETED
Conditions: Suicidal Ideation|Suicidal Behaviors|Suicide
Interventions: BEHAVIORAL: LifePlans|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GAmified HOme-based COgnitive-Nutritional Training Feasibility Study
Status: UNKNOWN
Conditions: Cognitive Frailty|Protective Diet Adherence|Cognitive Function|Frailty|Nutrition|Body Composition
Interventions: DEVICE: GAmified HOme-based COgnitive-Nutrition training (GAHOCON)|DEVICE: Centre-based online open-source cognitive games
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination HTNV and PUUV DNA Vaccine
Status: UNKNOWN
Conditions: Hantaan Virus Disease, Puumala Virus
Interventions: COMBINATION_PRODUCT: Hantann virus vaccine (HTNV) - Using TriGrid Delivery System (TDS) for Intradermal Delivery (ID)|COMBINATION_PRODUCT: Hantann virus vaccine (HTNV) - Using TriGrid Delivery System (TDS) for Intramuscular Delivery (IM)|COMBINATION_PRODUCT: Puumala virus vaccine (PUUV) - Using the TriGrid Delivery System (TDS) for Intradermal Delivery (ID)|COMBINATION_PRODUCT: Puumala virus vaccine (PUUV) - Using the TriGrid Delivery System (TDS) for Intramuscular Delivery (IM)|COMBINATION_PRODUCT: Hantaan/Puumala (HTNV/PUUV) virus vaccines - Using the TriGrid Delivery System (TDS) for Intradermal Delivery (ID)|COMBINATION_PRODUCT: Hantaan/Puumala (HTNV/PUUV virus vaccines - Using the TriGrid Delivery System (TDS) for Intramusular Delivery (IM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase I Safety and Immunogenicity Trial of Vaccinia-HIV Envelope Recombinant Vaccine (HIVAC-1e) in Combination With Soluble Recombinant Envelope Vaccine (gp160; VaxSyn)
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: HIVAC-1e|BIOLOGICAL: gp160 Vaccine (MicroGeneSys)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Usage, Usability & Effect on Adherence and Clinical Outcomes of Text Message Reminders for Adolescents With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: Text Message Reminders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Italian Cardioneuroablation Study for Neurocardiogenic Syncope Patients
Status: RECRUITING
Conditions: Neurally Mediated Syncope
Interventions: PROCEDURE: Transcatheter ablation of cardiac ganglionated plexi
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Double Blind Vehicle Controlled Study of 15% AS101 Gel to Treat External Genital Warts
Status: UNKNOWN
Conditions: External Genital Warts
Interventions: DRUG: 15% AS101 gel|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease
Status: RECRUITING
Conditions: Crohn Disease|Colitis, Ulcerative
Interventions: DRUG: TEV-48574|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Extended Yellow Fever Vaccine Information on Symptom Reports Following Vaccination
Status: COMPLETED
Conditions: Vaccination
Interventions: BEHAVIORAL: Extended information on side effects
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of a Candidate Clostridium Difficile Toxoid Vaccine in Healthy Adult Subjects Aged 40 to 75 Years in Japan
Status: COMPLETED
Conditions: Clostridium Difficile Infection
Interventions: BIOLOGICAL: Clostridium difficile Toxoid Vaccine|BIOLOGICAL: 0.9% normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Social Media for Colorectal Cancer Screening
Status: UNKNOWN
Conditions: Colorectal Cancer|Cancer Screening
Interventions: OTHER: Social media message #1|OTHER: Social media message #2|OTHER: Social media message #3|OTHER: Tailored social media messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Provider-Mediated Communication of Genetic Testing Results to At-Risk Relatives of Cancer Patients to Improve Genetic Counseling and Testing Rates, Family HOPE Study
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid System Neoplasm|Hereditary Malignant Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Best Practice|OTHER: Electronic Health Record Review|BEHAVIORAL: Personal Contact|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Dose-Escalating Study of Obinutuzumab in Patients With B-lymphocyte Antigen (CD20+) Malignant Disease (GAUGUIN)
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: iFR Pressure Wires in Assessment of the Provisional Side-branch Intervention Strategy for Bifurcation Lesions
Status: COMPLETED
Conditions: Coronary Bifurcation Lesions
Interventions: DEVICE: iFR pressure-wire|DEVICE: Conventional
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Piloting a Dietary Vitamin E Intervention During Pregnancy
Status: COMPLETED
Conditions: Asthma
Interventions: DIETARY_SUPPLEMENT: Vitamin E enhanced soup|DIETARY_SUPPLEMENT: Non-enhanced soups
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oral SAR245408 (XL147) and Oral MSC1936369B in Patients With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: SAR245408 (XL147)|DRUG: MSC1936369B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Treximet (Sumatriptan/Naproxen Sodium), Formerly Known as Trexima, In The Acute Treatment Of Multiple Migraine Attacks
Status: COMPLETED
Conditions: Migraine Disorders|Migraine
Interventions: DRUG: sumatriptan succinate/naproxen sodium|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The SongDance Study: Stress, Ongoing Self- Monitoring and Diabetes, Nerve Stimulation and Cognitive Empowerment
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2, Stress
Interventions: DEVICE: active stress handling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neo-DIANA: Neoadjuvant Treatment for EGFR Mutated Patients
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer|EGFR Gene Mutation
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab|DRUG: Carboplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurostimulation and Mirror Therapy in Traumatic Brachial Plexus Injury
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DEVICE: TRANSCRANIAL DIRECT CURRENT STIMULATION AND MIRROR THERAPY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotic (Visbiome) for Gulf War Illness
Status: UNKNOWN
Conditions: Gulf War Illness
Interventions: DRUG: Placebo|DRUG: Visbiome|DRUG: VSL#3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Milk Oligosaccharides (HMOs) and Gut Microbiota, Immune System in Antarctica
Status: ENROLLING_BY_INVITATION
Conditions: Healthy Adults|High Altitude|Isolation, Social
Interventions: DIETARY_SUPPLEMENT: Human milk oligosaccharides|DIETARY_SUPPLEMENT: Maltose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ARQ 501 in Patients With Squamous Cell Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Head and Neck Neoplasms|Carcinoma, Squamous Cell
Interventions: DRUG: ARQ 501
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Intravenous Omeprazole to Ranitidine on Recurrent Bleeding After Endoscopic Treatment of Bleeding Ulcer
Status: WITHDRAWN
Conditions: Peptic Ulcers
Interventions: DRUG: Omeprazole|DRUG: Ranitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy and Safety of Telitacicept and Belimumab in Active Lupus Nephritis in the Real World: a Prospective Cohort Study
Status: NOT_YET_RECRUITING
Conditions: Lupus Nephritis|Belimumab|Telitacicept
Interventions: DRUG: Belimumab|DRUG: Telitacicept
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Brimonidine Tartrate Ophthalmic Solution in Adult and Geriatric Participants With Ocular Redness
Status: COMPLETED
Conditions: Hyperemia
Interventions: DRUG: Brimonidine Tartrate|DRUG: Vehicle|DRUG: Sodium Fluorescein|DRUG: Fluorescein Sodium and Benoximate Hydrocholoride Ophthalmic Solution USP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Functional Evaluation of Two Infant Formula Supplemented With Probiotics Isolated From Breast Milk
Status: COMPLETED
Conditions: Infant Nutrition
Interventions: DIETARY_SUPPLEMENT: Lfer|DIETARY_SUPPLEMENT: Bifido|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors
Status: COMPLETED
Conditions: Childhood Atypical Teratoid/Rhabdoid Tumor|Childhood Central Nervous System Choriocarcinoma|Childhood Central Nervous System Embryonal Tumor|Childhood Central Nervous System Germinoma|Childhood Central Nervous System Mixed Germ Cell Tumor|Childhood Central Nervous System Teratoma|Childhood Central Nervous System Yolk Sac Tumor|Childhood Choroid Plexus Tumor|Childhood Craniopharyngioma|Childhood Ependymoblastoma|Childhood Grade I Meningioma|Childhood Grade II Meningioma|Childhood Grade III Meningioma|Childhood High-grade Cerebellar Astrocytoma|Childhood High-grade Cerebral Astrocytoma|Childhood Infratentorial Ependymoma|Childhood Low-grade Cerebellar Astrocytoma|Childhood Low-grade Cerebral Astrocytoma|Childhood Medulloepithelioma|Childhood Mixed Glioma|Childhood Oligodendroglioma|Childhood Supratentorial Ependymoma|Extra-adrenal Paraganglioma|Recurrent Childhood Brain Stem Glioma|Recurrent Childhood Central Nervous System Embryonal Tumor|Recurrent Childhood Cerebellar Astrocytoma|Recurrent Childhood Cerebral Astrocytoma|Recurrent Childhood Ependymoma|Recurrent Childhood Medulloblastoma|Recurrent Childhood Pineoblastoma|Recurrent Childhood Spinal Cord Neoplasm|Recurrent Childhood Subependymal Giant Cell Astrocytoma|Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor|Recurrent Childhood Visual Pathway and Hypothalamic Glioma
Interventions: DRUG: vorinostat|DRUG: temozolomide|OTHER: diagnostic laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT