pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Prevention of Non-Surgical Bleeding by Management of HeartMate II Patients Without Antiplatelet Therapy
Status: COMPLETED
Conditions: Heart Failure
Interventions: DEVICE: HeartMate II (HMII)|DRUG: Warfarin|DRUG: acetylsalicylic acid (ASA) therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Using Teleneuropsychology to Optimize Cognition in Healthy Aging: the Web-based Breakfast Game
Status: COMPLETED
Conditions: Healthy Aging
Interventions: BEHAVIORAL: Web-based training strategy|BEHAVIORAL: Web-based regular training (no strategy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Patients With Acetylcholine Receptor Binding Antibody Seronegative Generalized Myasthenia Gravis
Status: RECRUITING
Conditions: Generalized Myasthenia Gravis
Interventions: BIOLOGICAL: Efgartigimod IV|OTHER: Placebo IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Trial For Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Breast Neoplasms|Cancer of the Breast
Interventions: DRUG: gemcitabine|DRUG: docetaxel|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Longitudinal Study on Diaframmatic Ultrasound in FSHD Patients
Status: RECRUITING
Conditions: FSHD1|FSHD2
Interventions: DIAGNOSTIC_TEST: Diaphragmatic ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: FDOPA PET and Nutritional Support in Parkinson's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson Disease|Idiopathic Parkinson Disease
Interventions: DIETARY_SUPPLEMENT: N acetyl cysteine|DRUG: [F-18] Fluorodopa Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Tramadol on Interscalene Brachial Plexus Block
Status: COMPLETED
Conditions: Shoulder Fracture|Shoulder Dislocation|Rotator Cuff Injury|Shoulder Arthritis
Interventions: DRUG: Ropivacaine - Tramadol|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Positive Activities Intervention to Improve Quality of Life in Collectivist Culture Cancer Patients and Their Caregivers
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: BEHAVIORAL: Behavioral Intervention|BEHAVIORAL: Behavioral Intervention|BEHAVIORAL: Behavioral Intervention|OTHER: Interview|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Propofol Versus Esketamine for Rapid Sequence Intubation in Critically Ill Patients
Status: RECRUITING
Conditions: Acute Respiratory Failure
Interventions: DRUG: Esketamine hydrochloride|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrochemotherapy Induces Changes in the Tumor Microenvironment of Cutaneous and Subcutaneous Metastases in Patients With Cutaneous Melanoma
Status: ENROLLING_BY_INVITATION
Conditions: Cutaneous Malignant Melanoma
Interventions: PROCEDURE: Electrochemotherapy with Intratumoral Cysplatin|PROCEDURE: Electrochemotherapy with Intravenous Bleomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pilot Testing of an Equity Focused and Trauma-informed Communication Intervention During Family-centered Rounds
Status: RECRUITING
Conditions: Hospitalism in Children|Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: Equity Focused and Trauma-Informed Communication Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Indacaterol on Inspiratory Capacity and Lung Function in Patients With COPD Versus Placebo and Formoterol
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Indacaterol (QAB149)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Manipulating Tobacco Constituents in Female Menthol Smokers
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: OTHER: Reduced Nicotine Content- Non Menthol|OTHER: Reduced Nicotine Content- Menthol|OTHER: Conventional Nicotine Content- Menthol|OTHER: Conventional Nicotine Content- Non Menthol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Irinotecan in Patients With Advanced Metastatic Breast Cancer Who Have Experienced Failure of an Anthracycline, a Taxane, and Capecitabine
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Evaluation of the Efficacy of Synvisc-One® for the Treatment of Patellofemoral Chondromalacia
Status: COMPLETED
Conditions: Chondromalacia Patella|Patellofemoral Pain Syndrome
Interventions: DEVICE: Synvisc-One™|OTHER: Sham Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small-Cell Lung Carcinoma
Interventions: DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Cixutumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tiotropium + Olodaterol Fixed Dose Combination (FDC) in Chronic Obstructive Pulmonary Disease (OTEMTO 1)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: tiotropium|DRUG: placebo|DRUG: olodaterol|DRUG: tiotropium|DRUG: tiotropium|DRUG: olodaterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: MONICA-SC: A Study to Evaluate the Efficacy, Safety and Tolerability of Blisibimod (A-623) Administration in Subjects With ITP
Status: WITHDRAWN
Conditions: Immune Thrombocytopenic Purpura|Idiopathic Thrombocytopenic Purpura
Interventions: BIOLOGICAL: Blisibimod|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Renal and Hormonal Effects of Pioglitazone
Status: COMPLETED
Conditions: Diabetes|Hypertension
Interventions: DRUG: Pioglitazone|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Vedolizumab in Biologic-naïve Korean Patients With Moderate to Severe Inflammatory Bowel Disease
Status: UNKNOWN
Conditions: Crohn's Disease and Ulcerative Colitis
Interventions: DRUG: Vedolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Paclitaxel Versus Irinotecan in Patients With Recurrent or Metastatic Gastric Cancer Who Progress Following First-line Therapy
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: Paclitaxel|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Adult Male Participants to Learn the Way Vericiguat is Absorbed With and Without Food When Taken as a Single Dose in Liquid Form Suitable for Children Compared to a 10 Milligram (mg) Tablet That Releases the Active Substance Immediately
Status: COMPLETED
Conditions: Heart Failure|Children
Interventions: DRUG: Vericiguat (BAY1021189) - Intervention A|DRUG: Vericiguat (BAY1021189) - Intervention B|DRUG: Vericiguat (BAY1021189) - Intervention C|DRUG: Vericiguat (Verquvo, BAY1021189) - Intervention D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Diet and Fecal Incontinence in Senior Women
Status: COMPLETED
Conditions: Accidental Bowel Leakage|Fecal Incontinence|Incontinence|Bowel Incontinence
Interventions: BEHAVIORAL: Diet Modification Pilot Program (DPM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: JZP458 - Recombinant Erwinia Asparaginase for Treatment of ALL / LBL Patients With Hypersensitivity to E. Coli-derived Asparaginase
Status: APPROVED_FOR_MARKETING
Conditions: Acute Lymphoblastic Leukemia|Lymphoblastic Lymphoma
Interventions: DRUG: Asparaginase Erwinia Chrysanthemi (recombinant)
Study Type: EXPANDED_ACCESS
Clinical trial: The Effect of Integrated Prevention and Treatment on Child Malnutrition and Health in Burkina Faso: a Cluster Randomized Intervention Study
Status: COMPLETED
Conditions: Child Acute Malnutrition
Interventions: DIETARY_SUPPLEMENT: LNS|BEHAVIORAL: Child's health and nutrition topics|BEHAVIORAL: National policy well-baby visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Pharmacokinetics of Ceftolozane/Tazobactam in Pediatric Participants With Nosocomial Pneumonia (MK-7625A-036)
Status: ACTIVE_NOT_RECRUITING
Conditions: Nosocomial Pneumonia
Interventions: DRUG: Ceftolozane/Tazobactam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Biomarkers in Participants With Heart Failure (MK-0000-344)
Status: WITHDRAWN
Conditions: Heart Failure
Interventions: PROCEDURE: Blood Draw|PROCEDURE: Loop Diuretic Withdrawal/Salt Load
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: WALNUTS for POWER: Polyphenols, Omega-3 Fatty Acids, Weight Loss, and EneRgy
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: OTHER: walnuts|OTHER: usual diet|OTHER: phone counseling with dietitian
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cervical And Self-Sample In Screening Study
Status: COMPLETED
Conditions: Cervical Cancer|Intraepithelial Neoplasia
Interventions: DEVICE: Eve Medical self-collection system©|DEVICE: cobas® PCR Female swab self-sampling|PROCEDURE: Physician-collected sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Evaluating the Expression Levels of MicroRNA-10b in Patients With Gliomas
Status: RECRUITING
Conditions: Astrocytoma|Oligodendroglioma|Oligoastrocytoma|Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|Anaplastic Oligoastrocytoma|Glioblastoma|Brain Tumors|Brain Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase I Study to Evaluate Pharmacokinetics, Efficacy and Safety of CT-P13 Subcutaneous in Patients With Active Crohn's Disease and Ulcerative Colitis
Status: COMPLETED
Conditions: Crohn's Disease|Ulcerative Colitis (Part 2 Only)
Interventions: BIOLOGICAL: CT-P13|BIOLOGICAL: CT-P13|BIOLOGICAL: CT-P13|BIOLOGICAL: CT-P13|BIOLOGICAL: CT-P13|BIOLOGICAL: CT-P13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does a Theory-Based Intervention to Improve Accountability Reduce Low-Value Preoperative Investigations in Patients Undergoing Ambulatory Surgery
Status: UNKNOWN
Conditions: Low-value Pre-operative Investigations
Interventions: BEHAVIORAL: Hospital Policy change
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Inappropriate Shock Reduction wIth PARAD+ Rhythm DiScrimination
Status: COMPLETED
Conditions: Tachycardia
Interventions: DEVICE: PARADYM DR model 8550; PARADYM CRT model 8750; PARADYM RF DR model 9550; PARADYM RF CRT model 9750; PARADYM RF CRT SonR model 9770
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coreg and HSRs-Updated Analysis
Status: COMPLETED
Conditions: Hypersensitivity
Interventions: DRUG: Carvedilol immediate release only|DRUG: Carvedilol extended release only|DRUG: Long acting β-blockers|DRUG: Other α1/β-adrenergic antagonists|DRUG: Short acting Non-selective β-blockers and short acting β1-Selective agents|OTHER: No β-blocker
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of an Apple Juice Drink With POs-Ca
Status: COMPLETED
Conditions: Food Preferences
Interventions: DIETARY_SUPPLEMENT: apple juice|DIETARY_SUPPLEMENT: apple juice with 0.5% POs-Ca|DIETARY_SUPPLEMENT: apple juice with 1% POs-Ca|DIETARY_SUPPLEMENT: apple juice with 1.5% POs-Ca|DIETARY_SUPPLEMENT: apple juice with 2% POs-Ca
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prospective US Radiofrequency SUI Trial
Status: UNKNOWN
Conditions: Urinary Incontinence, Stress
Interventions: DEVICE: Active treatment|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Comparing Endometrial Transformation With Subcutaneous Progesterone Versus Intramuscular Progesterone
Status: COMPLETED
Conditions: Reproductive Techniques, Assisted
Interventions: DRUG: Subcutaneous progesterone|DRUG: Intramuscular progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention
Status: RECRUITING
Conditions: Depression and Suicide
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema
Status: COMPLETED
Conditions: Corneal Edema
Interventions: DEVICE: Hyper CL|DRUG: saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnesium Sulfate for Fetal Neuroprotection
Status: UNKNOWN
Conditions: Fetal Neuroprotection
Interventions: DRUG: MgSo4|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy, Safety, and Treatment Patterns of Transcatheter Arterial Chemoembolization (TACE) Combined With Atezolizumab and Bevacizumab in Unresectable Hepatocellular Carcinoma: a Multicenter, Retrospective, Observational Real-world Study
Status: NOT_YET_RECRUITING
Conditions: HCC
Interventions: DRUG: TACE
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Ritonavir (an Anti-HIV Drug) in HIV-Positive Infants and Children
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Ritonavir|DRUG: Lamivudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Laser Settings on Postoperative Voiding Symptoms in Patients Undergoing Holmium Laser Enucleation of the Prostate
Status: WITHDRAWN
Conditions: Prostate Disease|Surgery
Interventions: DEVICE: 120W Lumenis Holmium:YAG laser 20J|DEVICE: 120W Lumenis Holmium:YAG laser 40 J|DEVICE: 120W Lumenis Holmium:YAG laser 60 J
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of Two Approved Drugs in Patients With Osteoarthritis (0966-219)
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: MK0966, rofecoxib|DRUG: Comparator: celecoxib, placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Focal Prostate Ablation Versus Radical Prostatectomy
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DEVICE: Focal HIFU treatment using Focal One (EDAP TMS) or TULSA-PRO (Profound Medical)|PROCEDURE: Radical prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ingenol Mebutate 0.05% Gel When Used After Cryotherapy in the Hypertrophic Actinic Keratoses
Status: COMPLETED
Conditions: Actinic Keratoses
Interventions: DRUG: Ingenol Mebutate|PROCEDURE: Cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence of Dysphagia in Intensive Care Patients With Tracheostomy
Status: UNKNOWN
Conditions: Dysphagia|Oropharyngeal Dysphagia
Interventions: DEVICE: high resolution impedance manometry with Automated Impedance Manometry analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study Determining Safety and Efficacy of Avena Sativa (Oat) Skincare Products for Treating Skin Dryness and Itching in Cancer Patients
Status: COMPLETED
Conditions: Ichthyosis|Pruritus
Interventions: OTHER: Avena Sativa Skincare Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of a Silicone Gel (Dermatix®) on Thoracic Scar Formation After Harvesting of Autologous Rib Cartilage
Status: UNKNOWN
Conditions: Cicatrix, Hypertrophic|Keloid
Interventions: DRUG: Silicone gel (Dermatix®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MK-3415, MK-6072, and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-001)
Status: COMPLETED
Conditions: Clostridium Difficile Infection
Interventions: BIOLOGICAL: MK-3415|BIOLOGICAL: MK-6072|BIOLOGICAL: MK-3415A|BIOLOGICAL: Placebo|DRUG: SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validating the Safety and Effectiveness of ENDOANGEL Upper Gastrointestinal Endoscope Image Auxiliary Diagnostic Software
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: OTHER: The reading process is assisted by ENDOANGEL|OTHER: No ENDOANGEL assistance during the reading process
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: 24 Months Safety and Efficacy Study of AADvac1 in Patients With Mild Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: BIOLOGICAL: AADvac1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Feasibility and Effect of PACUTS on Health Promotion for Stroke Wheelchair User in Long-term Care Institution
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: computer task intervention|OTHER: conventional long-term care services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protocol Validation of Dynamometric Measurement of Passive Inter-segmental Stiffness and Spasticity in Children With Cerebral Palsy
Status: RECRUITING
Conditions: Cerebral Palsy
Interventions: DEVICE: Assessment of the reliability of a protocol characterizing intersegmental hyper-resistance to passive stretch
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Evaluate the Efficacy of Bu-Yang- Huan-Wu Tang（BYHWT）on Ischemic Stroke
Status: UNKNOWN
Conditions: Ischemic Stroke
Interventions: DRUG: Bu-Yang-Huan-Wu Tang
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Relative Oral Bioavailability of a Single Dose of JNJ-63623872/Oseltamivir Fixed-dose Combination Tablet and Single Agent Concept Formulations of JNJ-63623872 Compared to Their Respective Reference Formulation in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-63623872|DRUG: Oseltamivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Wax Use for Hemostasis During Primary Unilateral Total Knee Arthroplasty
Status: TERMINATED
Conditions: Total Knee Replacement
Interventions: DEVICE: Bone wax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: An Open-label, Non-randomized, Parallel Group Study in Subjects With Mild, Moderate, Severe, or No Renal Impairment
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Deferiprone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Safety Extension Trial of Inhaled Molgramostim in Autoimmune Pulmonary Alveolar Proteinosis
Status: TERMINATED
Conditions: Autoimmune Pulmonary Alveolar Proteinosis
Interventions: DRUG: Molgramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Whole Health in VA Mental Health: Omnis Salutis
Status: RECRUITING
Conditions: Stress Disorders, Post-Traumatic|Depressive Disorder|Anxiety Disorders|Substance-Related Disorders
Interventions: BEHAVIORAL: Omnis Salutis|BEHAVIORAL: Health and Wellness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Maxalt 10mg Plus Caffeine 75mg in the Acute Treatment of Migraine Headache
Status: COMPLETED
Conditions: Migraine With Aura|Migraine Without Aura
Interventions: DRUG: Maxalt 10mg MLT plus Caffeine 75mg|DRUG: Maxalt 10mg MLT plus Placebo|DRUG: Placebo + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Epidemiological Investigation of Helicobacter Pylori-infected Patients and the Effect of Eradication Treatment on Dyspepsia Symptoms
Status: RECRUITING
Conditions: Helicobacter Pylori Infection|Dyspepsia
Interventions: OTHER: Epidemiological questionnaire and Functional Dyspepsia Symptom Diary（FDSD）
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Single Dose Bioequivalence Study OfTwo Formulations Of Nicotine Lozenges
Status: COMPLETED
Conditions: Healthy Volunteer Smokers
Interventions: DRUG: 4 mg nicotine lozenge|DRUG: 2 mg nicotine lozenge|DRUG: 2 mg nicotine prototype|DRUG: 4 mg nicotine prototype
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic, Safety, Tolerability and Immunogenicity Study of SB4 in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: SB4|BIOLOGICAL: EU sourced Enbrel|BIOLOGICAL: US sourced Enbrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Compare S-1 for 6 Months to 1 Year as Adjuvant Chemotherapy After D2 Resection in Patients With Gastric Cancer Staged II , IIIA or IIIB.
Status: WITHDRAWN
Conditions: Gastric Cancer
Interventions: DRUG: S-1 for 6 months|DRUG: S-1 for 1 year
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of an Ocular Emulsion in Meibomian Gland Dysfunction
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction
Interventions: DRUG: Systane Balance|DRUG: Optive Lubricant Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Specialized Proresolving Mediators in Pneumocystis Jirovecii Pneumonia
Status: COMPLETED
Conditions: Pneumonia, Pneumocystis
Interventions: OTHER: Blood sampling|OTHER: urine sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Exploratory Pilot Study to Evaluate the Pharmacokinetic Profile of Magaldrate
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Sodium alginate + sodium bicarbonate + magaldrate + simeticone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Of Sertraline Compared With Paroxetine In The Treatment Of Panic Disorder
Status: COMPLETED
Conditions: Panic Disorder
Interventions: DRUG: sertraline|DRUG: Paroxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY II)
Status: COMPLETED
Conditions: Agitation|Dementia
Interventions: DRUG: BXCL501|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of ESWT and PNF in Scleroderma With Calcinosis
Status: NOT_YET_RECRUITING
Conditions: Scleroderma|Calcinosis Cutis
Interventions: DEVICE: Extracorporeal Shock Wave Therapy (ESWT)|OTHER: PNF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Health-Economic Evaluation of Early Diagnosis of Epithalial Ovarian Cancer Recurrence Using the ROMA Score: a Prospective Multicenter Randomized Trial
Status: NOT_YET_RECRUITING
Conditions: Epithelial Ovarian Cancer
Interventions: DIAGNOSTIC_TEST: ROMA score evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Combined Treatment of Sintilimab, Peg-aspargase Plus Anlotinib in NK/T Cell Lymphoma
Status: COMPLETED
Conditions: Natural Killer/T-Cell Lymphoma, Nasal and Nasal-Type|Early Stage|Anlotinib|Peg-aspargase|Sintilimab|Phase Two|Open|Radiotherapy
Interventions: DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy of Pharmacology and Non-pharmacological Treatment in Women With Primary Dysmenorrhea.
Status: COMPLETED
Conditions: Pelvic Floor|Exercise|Telerehabilitation|Acupressure|Dysmenorrhea Primary|Drug Effect
Interventions: OTHER: Conservative and Non-conservative treatments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept Study Efficacy of an Antacid/Lansoprazole Combination for Relief of Heartburn
Status: COMPLETED
Conditions: Heartburn
Interventions: DRUG: Calcium carbonate/magnesium hydroxide/Lansoprazole 15 mg|DRUG: Lansoprazole|DRUG: Calcium carbonate/magnesium hydroxide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Yeahhh Baby! Ointment on Hip and/or Knee Pain in Men and Women
Status: COMPLETED
Conditions: Joint Pain
Interventions: DIETARY_SUPPLEMENT: Yeahhh Baby Ointment|OTHER: Coconut oil ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant Trial of Capecitabine for Axillary Lymph Node Positive Operable Breast Cancer
Status: UNKNOWN
Conditions: Stage II Breast Cancer|Stage III Breast Cancer
Interventions: DRUG: fluorouracil|DRUG: capecitabine|DRUG: cyclophosphamide|DRUG: Epirubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest of Nasal Provocation Tests for Diagnosis of House Mites Allergic Rhinitis
Status: TERMINATED
Conditions: Mite Allergy|Respiratory Disease
Interventions: DRUG: Nasal provocation test - 725 Dermatophagoides Pteronyssinus|OTHER: Negative control
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cohort of Patients Infected by an Arbovirus
Status: RECRUITING
Conditions: Fever|Dengue|Chikungunya|Zika Virus
Interventions: OTHER: biological sample collection|OTHER: Quality of life Questionnaire EuroQol®|OTHER: Health Assessment Questionnaire - MDHAQ and RAPID3|OTHER: Neuropathic Pain Questionnaire (DN4)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lateral Epicondylitis Treatment High Intensive Laser Therapy and Extracorporeal Shock Wave Therapy
Status: COMPLETED
Conditions: Lateral Epicondylitis
Interventions: DEVICE: high intensive laser|DEVICE: extracorporeal shock wave therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TLR-9 Adjuvanted Vaccination for Chronic Hepatitis B
Status: WITHDRAWN
Conditions: Hepatitis B
Interventions: DRUG: Hepatitis B Vaccine Recombinant, Adjuvanted Intramuscular Solution [HEPLISAV-B]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Shot vs Catheter Infraclavicular Brachial Plexus Block After Distal Radius Fracture Repair
Status: TERMINATED
Conditions: Distal Radius Fracture|Post Operative Pain Control
Interventions: DRUG: 20ml bolus of 0.5% ropivicaine|DRUG: 0.2% of ropivacaine at 8 milliliter/hour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of the Efficacy and Safety of Psoralait Versus Placebo in the Treatment of Psoriasis
Status: TERMINATED
Conditions: Psoriasis
Interventions: OTHER: Psoralait|OTHER: Placebo cream.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Evaluation to Reduce Imaging Testing
Status: RECRUITING
Conditions: Chronic Coronary Syndrome
Interventions: DIAGNOSTIC_TEST: 2019 ESC guideline-determined diagnostic strategy|DIAGNOSTIC_TEST: 2016 NICE guideline-determined diagnostic strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Magnetic Anastomosis Device Relief of Malignant Gastric Outlet Obstruction
Status: TERMINATED
Conditions: Gastric Outlet Obstruction
Interventions: DEVICE: Cook Magnetic Anastomosis Device (MAD) with Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Trial of Pentoxifylline in Patient With Cirrhosis
Status: COMPLETED
Conditions: Cirrhosis|Liver Failure
Interventions: DRUG: pentoxifylline|DRUG: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Electroporation for Treatment of Atrial Fibrillation
Status: ENROLLING_BY_INVITATION
Conditions: Persistent Atrial Fibrillation|Longstanding Persistent Atrial Fibrillation
Interventions: OTHER: Pulse field ablation|OTHER: Radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Cefepime and AAI101 in Subjects With Renal Insufficiency and Healthy Subjects
Status: COMPLETED
Conditions: PK in Patients With Various Degrees of Renal Impairment
Interventions: DRUG: cefepime/AAI101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A First in Human Study of CMND-100 in Healthy and Alcohol Use Disorder (AUD) Subjects
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder
Interventions: DRUG: CMND-100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy and Interleukin-12 in Treating Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: MART-1 antigen|BIOLOGICAL: recombinant MAGE-3.1 antigen|BIOLOGICAL: recombinant interleukin-12
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 4-Arm Efficacy and Safety Study of RT001 for the Treatment of Moderate to Severe Lateral Canthal Lines in Adults
Status: COMPLETED
Conditions: Lateral Canthal Lines|Crow's Feet|Facial Wrinkles
Interventions: DRUG: RT001 Botulinum toxin type A (Dose A)|DRUG: RT001 Botulinum Toxin Type A (Dose B)|OTHER: Vehicle|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Preventive Treatment With Symbicort or Budicort Turbohaler in Childhood Asthma Return to School Epidemic
Status: UNKNOWN
Conditions: Asthma Exacerbation
Interventions: DRUG: Budesonide turbuhaler, Budesonide+Formoterol turbuhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ruxolitinib and Venetoclax in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: SUSPENDED
Conditions: Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Ruxolitinib|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Subcutaneous Rehydration With Recombinant Human Hyaluronidase for Infants and Children
Status: COMPLETED
Conditions: Dehydration
Interventions: DRUG: hyaluronidase (human recombinant)/rehydration fluid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methodology Issues in a Tailored Light Treatment for Persons With Dementia
Status: COMPLETED
Conditions: Sleep Disturbances|Depression
Interventions: OTHER: Tailored Active intervention|OTHER: Inactive intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of [11C]JNJ-42491293, a Possible PET Ligand for the mGlu2 Receptor, in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: [11C] JNJ-42491293|DRUG: [11C] JNJ-42491293 + JNJ-40411813|DRUG: [11C] JNJ-42491293 + JNJ-40411813|DRUG: [11C] JNJ-42491293
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Combined Bone Marrow and Renal Transplantation for Hematologic Disorders With End Stage Renal Disease
Status: COMPLETED
Conditions: Multiple Myeloma|Amyloidosis
Interventions: DRUG: Tacrolimus|DRUG: Equine Anti-thymocyte globulin|PROCEDURE: Kidney transplant from a related donor|DRUG: Bone marrow transplant from a related donor|RADIATION: Total body irradiation 400 centigray (200 cGy X 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effect of Dietary Nitrate Treatment on Endothelial Function and Platelet Reactivity in Hypercholesterolemics.
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Naloxone Education in Total Joint Patients
Status: UNKNOWN
Conditions: Opioid Use|Pain, Musculoskeletal|Surgery|Overdose of Opiate
Interventions: OTHER: Pre-hospital naloxone education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase II Study In Patients With Advanced Head And Neck Cancer Of Standard Chemoradiation And Add-On Cetuximab
Status: COMPLETED
Conditions: Oropharyngeal Cancer|Hypopharyngeal Cancer|Laryngeal Cancer
Interventions: DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Topical Use of Platelet-rich Plasma Versus Hyaluronic Acid During Endoscopic Fat Graft Myringoplasty: a Randomized Clinical Study
Status: NOT_YET_RECRUITING
Conditions: Chronic Suppurative Otitis Media
Interventions: PROCEDURE: enoscopic Myringoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Argatroban in Critically Ill Patients With Heparin Resistance
Status: COMPLETED
Conditions: Achievement of a Sufficient Thrombosis Prohpylaxis in Clitically Ill Patients With Heparin Resistance
Interventions: DRUG: Argatroban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics Study of Amlodipine 10mg and Candesartan 32mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: candesartan cilexetil 32mg, amlodipine 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of Pimavanserin in Adult and Elderly Subjects Experiencing Neuropsychiatric Symptoms Related to Neurodegenerative Disease
Status: COMPLETED
Conditions: Neuropsychiatric Symptoms Related to Neurodegenerative Disease
Interventions: DRUG: Pimavanserin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral Treatment and Memantine in Body Focused Repetitive Behaviors
Status: RECRUITING
Conditions: Skin-Picking|Trichotillomania (Hair-Pulling Disorder)
Interventions: DRUG: Memantine|BEHAVIORAL: ComB Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ovarian Hyperstimulation Syndrome in Patients Triggered by GnRH Agonist for Excessive Follicular Response
Status: TERMINATED
Conditions: Ovarian Hyperstimulation Syndrome|Hypercoagulability
Interventions: OTHER: COAGO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Auditory Diagnostics and Error-based Treatment
Status: RECRUITING
Conditions: Deafness, Bilateral|Deafness Neurosensory|Deafness Permanent
Interventions: DIAGNOSTIC_TEST: Tone Audiometry|DIAGNOSTIC_TEST: Spectrotemporal Assessment|DIAGNOSTIC_TEST: Phoneme and Speech Perception|DIAGNOSTIC_TEST: Digit Triplet Test|OTHER: Personalized fitting|BEHAVIORAL: Personalized training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of a Clinically-relevant Test for Assessment of Cerebral Vascular Function
Status: UNKNOWN
Conditions: Cerebrovascular Disorders|Cerebrovascular Disease
Interventions: PROCEDURE: Flow mediated dilation (brachial and femoral arteries)|PROCEDURE: Cerebral vascular reactivity to carbon dioxide (CO2)|PROCEDURE: Cerebral vascular function test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Linking Cardiac Autonomic Dysfunction and InfLammation in Patients With Acute Coronary Syndromes
Status: RECRUITING
Conditions: Acute Coronary Syndrome|Myocardial Ischemia
Interventions: DIAGNOSTIC_TEST: Anamnesis and clinical evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Specialized Substance Abuse Supervision (SSAS) Versus Non-SSAS Recidivism Rates Among Nebraska Felony Drug Offenders
Status: COMPLETED
Conditions: Substance-related Disorders|Alcohol-related Disorders
Interventions: BEHAVIORAL: Specialized Substance Abuse Supervision (SSAS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase II Study Evaluating Busulfan and Fludarabine as Preparative Therapy in Adults With Hematopoietic Disorders Undergoing MUD SCT
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia|Acute Myelogenous Leukemia|Myelodysplasia|Acute Lymphocytic Leukemia|Severe Aplastic Anemia|Non-Hodgkin's Lymphoma|Lymphoproliferative Disease|Multiple Myeloma|Advanced Myeloproliferative Disease
Interventions: DRUG: Busulfan/Fludarabine phosphate/Tacrolimus/Methotrexate/G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genome-Wide Association Study With the Aim of Implantable Cardioverter Defibrillator Implantation Genophenotypic Risk Stratification
Status: NOT_YET_RECRUITING
Conditions: ICD|Arrythmia|Sudden Cardiac Death
Interventions: OTHER: Non-Invasive saliva sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy Study of Stenting, Paclitaxel Eluting Balloon or Atherectomy to Treat Peripheral Artery Disease
Status: UNKNOWN
Conditions: Peripheral Vascular Diseases
Interventions: DEVICE: Stenting (Smart Stent)|DEVICE: Stenting after PEB (Smart Stent, Invatec)|PROCEDURE: Atherectomy (SilverHawk device)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics and Systemic Inflammation in Patients With Metabolic Syndrome and High Cardiovascular Risk
Status: WITHDRAWN
Conditions: Metabolic Syndrome|Cardiovascular Risk Factor
Interventions: DIETARY_SUPPLEMENT: Probiotic mix|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Anlotinib Combined With Dose-reduced Olaparib in Patients With Platinum-Sensitive Recurrent Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer|Ovarian and Fallopian Tube Cysts and Neoplasms|Neoplasms by Site|Neoplasms|Genital Neoplasms, Female|Urogenital Neoplasms|Neoplasms, Glandular and Epithelial|Neoplasms by Histologic Type|Carcinoma, Ovarian Epithelial|Ovarian Diseases|Adnexal Diseases|Genital Diseases, Female|Carcinoma|Anlotinib|PARP Inhibitors|BRCA1 Mutation|Angiogenesis|Antineoplastic Agents|BRCA2 Mutation
Interventions: DRUG: Anlotinib|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Dose Pharmacokinetics of Intranasal Azelastine Delivered by a Fixed Combination With Fluticasone in Comparison to Azelastine Nasal Sprays
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Azelastine, Fluticasone|DRUG: Azelastine mono|DRUG: Azelastine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylaxis of Surgical Wound Infection in Incisional Hernia Repair With Topical Antibiotics (PROTOP-PAR)
Status: COMPLETED
Conditions: Postoperative Hernia
Interventions: DRUG: Wound irrigation with amoxicillin-clavulanate in saline solution|DRUG: Wound irrigation with a saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION