pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase 2 Study of LUM-201 in Children With Growth Hormone Deficiency (OraGrowtH210 Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Growth Hormone Deficiency
Interventions: DRUG: LUM-201|DRUG: rhGH Norditropin® pen (34 µg/kg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dimethyl Fumarate for Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|OSA|Sleep Apnea
Interventions: DRUG: Dimethyl fumarate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Safe and Tolerable Dose of GMA301 Injection in Healthy Volunteers
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: GMA301 Injection|OTHER: GMA301 Placebo Injection|DRUG: GMA301 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 4-Methylumbelliferone as a Treatment for Chronic HBV/HCV
Status: UNKNOWN
Conditions: Chronic Hepatitis C|Chronic Hepatitis B
Interventions: DRUG: 4-Methylumbelliferone (Heparvit®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparing Transperineal to Transrectal MRI-US Fusion Prostate Biopsy
Status: UNKNOWN
Conditions: Prostate Biopsy
Interventions: PROCEDURE: Transperineal mpMRI-US Fusion prostate biopsy|PROCEDURE: Transrectal mpMRI-US Fusion prostate biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Impact of Riboflavin on Sports-related Concussion
Status: UNKNOWN
Conditions: Sports-related Concussion
Interventions: BIOLOGICAL: Riboflavin|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of GSK2862277 in Subjects Undergoing Oesophagectomy Surgery
Status: TERMINATED
Conditions: Lung Injury, Acute and Respiratory Distress Syndrome, Adult
Interventions: DRUG: GSK2862277|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2
Status: COMPLETED
Conditions: Neurofibromatosis 2
Interventions: DEVICE: Multichannel Auditory Brain Stem Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Efficacy of Tafasitamab Combined With Lenalidomide in Patients With Relapsed or Refractory DLBCL
Status: RECRUITING
Conditions: DLBCL
Interventions: DRUG: Tafasitamab and Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LYT-100 in Patients With BCRL
Status: TERMINATED
Conditions: Breast Cancer Related Lymphoedema|Lymphoedema
Interventions: DRUG: LYT-100 BCRL|DRUG: Placebo BCRL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of Co-artemether in Non-immune Travelers
Status: COMPLETED
Conditions: Acute Uncomplicated P. Falciparum Malaria
Interventions: DRUG: Co-artemether
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coronary Sinus Reducer Objective Impact on Symptoms, MRI Ischaemia and Microvascular Resistance
Status: RECRUITING
Conditions: Refractory Angina
Interventions: DEVICE: Coronary Sinus Reducer|PROCEDURE: Placebo Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selection of the Embryo to Transfer by Morphokinetics vs. Morphological Evaluation.
Status: UNKNOWN
Conditions: Embryo Implantation
Interventions: OTHER: Morpho-kinetics selection with time-lapse (Embryoscope) evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Novel mHealth Approach to Assess and Manage Palliative Care Needs for Cancer Patients in Kigali
Status: WITHDRAWN
Conditions: Cancer Pain
Interventions: OTHER: Standard palliative care|OTHER: Smart Phone based symptom evaluation application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 3-year Follow-up After a Single Dose Acellular Pertussis Vaccination
Status: COMPLETED
Conditions: Pertussis
Interventions: BIOLOGICAL: Pertagen (aP BioNet)|BIOLOGICAL: Boostagen (TDaP BioNet)|BIOLOGICAL: Adacel
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Investigate the Safety and Pharmacokinetics of a Single Dose of GSK2256294 in Healthy Young Males and Elderly Subjects
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK2256294
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Lidocaine Administration on Postoperative Complications During Lung Resection Surgery
Status: COMPLETED
Conditions: Lung Diseases|Lung Inflammation|Lung Injury, Acute|Postoperative Complications
Interventions: DRUG: Lidocaine|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Improving Outcomes and Lowering Costs by Integration of Primary Care Providers and Pain Medicine Physicians for Pain Pts
Status: TERMINATED
Conditions: Back Pain|Chronic Pain|Pain, Intractable
Interventions: OTHER: Group 2 (PCP Treatment)|OTHER: Group 1 (PMS Treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Value of Liquid Potassium Magnesium Citrate in Controlling Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Potassium chloride powder|DRUG: Potassium citrate powder|DRUG: Potassium magnesium citrate powder|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability of Eslicarbazepine Acetate in the Recurrence Prevention of Bipolar I Disorder
Status: COMPLETED
Conditions: Bipolar I Disorder
Interventions: DRUG: BIA 2-093 1800 mg once daily [Group 1 (Part II)]|DRUG: BIA 2-093 900 mg once daily [Group 2 (Part II)]|DRUG: BIA 2-093 300 mg once daily [Group 3 (Part II)]|DRUG: BIA 2-093 900 mg (Part I)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Glycemic Effects of Nebivolol Compared With Metoprolol and HCTZ in Diabetic Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension|Type 2 Diabetes Mellitus
Interventions: DRUG: Nebivolol|DRUG: Metoprolol ER|DRUG: HCTZ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: T-Lymphocytes Genetically Targeted to the B-Cell Specific Antigen CD19 in Pediatric and Young Adult Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed B-Cell Acute Lymphoblastic Leukemia
Interventions: PROCEDURE: leukapheresis or collection of PBMCs|DRUG: cyclophosphamide based chemotherapy regimens|BIOLOGICAL: modified T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Antenatal Corticosteroids on Neonatal Morbidity.
Status: COMPLETED
Conditions: Neonatal Respiratory Distress Syndrome
Interventions: DRUG: Dexamethasone Sodium Phosphate Injection|DRUG: Betamethasone Sodium Phosphate Injection (Medication)|DRUG: Water for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Best Incision in Cesarean Section of Obese Women
Status: COMPLETED
Conditions: Morbid Obesity|Cesarean Section Complications
Interventions: PROCEDURE: Pfannenstiel incision|PROCEDURE: Supra-umbilical transverse incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Mesenchymal Stem Cells For Infants At High Risk For Bronchopulmonary Dysplasia
Status: UNKNOWN
Conditions: Bronchopulmonary Dysplasia
Interventions: DRUG: Transplantation of hUC-MSCs|DRUG: No transplantation of hUC-MSCs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of Topical 10% Terbinafine Hydrogen Chloride Versus 5% Amorolfine Nail Lacquer in Patients With Mild to Moderate Toenail Onychomycosis
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: terbinafine hydrogen chloride|DRUG: amorolfine nail lacquer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Resolution Microendoscopy for the Detection of Esophageal Squamous Cell Neoplasia
Status: UNKNOWN
Conditions: Suspected or Known Squamous Cell Neoplasia|Prior History of Squamous Cell Dysplasia and /or Neoplasia
Interventions: DRUG: Proflavine, high resolution imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Oral Health Promotion Among Preschool Children With Special Needs
Status: COMPLETED
Conditions: Intellectual Disability|Cerebral Palsy|Developmental Disorders|Developmental Delay|Autistic Spectrum Disorders|Down Syndrome|Epilepsy|Developmental Disability|Learning Disorders
Interventions: OTHER: Visual pedagogy (social stories)|OTHER: Conventional leaflets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cupping Therapy on Immune System in Post Covid -19
Status: COMPLETED
Conditions: Covid-19 Patients
Interventions: COMBINATION_PRODUCT: Cupping therapy with convential medical treatment|DRUG: Convential medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ulcerative Colitis Leukocyte TRAfficking After Treatment With Zeposia: the ULTRAZ Study
Status: WITHDRAWN
Conditions: Ulcerative Colitis
Interventions: DRUG: Ozanimod Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of the National Colorectal Cancer Roundtable Toolbox (NCCRT) to Increase Colorectal Cancer Screening Rates
Status: COMPLETED
Conditions: Colorectal Cancer Screening
Interventions: BEHAVIORAL: National Colorectal Cancer Roundtable Toolbox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Immunogenicity and Safety of Two Adjuvant Formulations of an Egg-Derived Pandemic Vaccine
Status: TERMINATED
Conditions: Healthy Subjects
Interventions: BIOLOGICAL: S205 placebo|BIOLOGICAL: S205 10ugHA|BIOLOGICAL: S205 30ugHA|BIOLOGICAL: S205 10ugHA+500ugAlOH|BIOLOGICAL: S205 30ugHA+500ugAlOH|BIOLOGICAL: S205 10ugHA+1250ugAlOH|BIOLOGICAL: S205 30ugHA+1250ugAlOH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of GS-6620 in Treatment Naïve Subjects With Chronic Hepatitis C Virus Infection
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: GS-6620|DRUG: GS-6620|DRUG: GS-6620|DRUG: GS-6620|DRUG: GS-6620|DRUG: GS-6620|DRUG: GS-6620 tablet, 450 mg BID|DRUG: GS-6620 tablet|DRUG: GS-6620 tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Clinical Performance of All-in-One Light Multi-purpose for Silicone Hydrogel Contact Lenses
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: All-in-One Light multipurpose|DEVICE: Aquify care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Comparison of Two Dosages of Heparin Before Extracorporeal Circulation
Status: COMPLETED
Conditions: Extracorporeal Circulation; Complications
Interventions: DIAGNOSTIC_TEST: ACT (Activated Clotting Time)|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Phase II Study to Evaluate the Efficacy of IdeS to Desensitize Transplant Patients With a Positive Crossmatch Test
Status: COMPLETED
Conditions: Kidney Failure, Chronic
Interventions: DRUG: IdeS|PROCEDURE: Kidney transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Paravertebral Block on Postoperative Pain After Hepatectomy
Status: COMPLETED
Conditions: Right Lobe Hepatectomy
Interventions: PROCEDURE: Continuous Paravertebral block with ropivacaine|PROCEDURE: Patient-controlled analgesia with sufentanil|PROCEDURE: Continuous Paravertebral Block with Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Concomitant Bladder Neck Incision and Urethral Valve Ablation on Surgical Re-intervention Rate for Patients With Posterior Urethral Valve
Status: UNKNOWN
Conditions: Pediatric Disorder|Hydronephrosis in Children|Hydronephrosis, Secondary|Hydronephrosis Congenital|Bladder-Neck; Obstruction, Congenital|Urethral Valve|Renal Function Disorder
Interventions: PROCEDURE: Valve ablation|PROCEDURE: Valve ablation and bladder neck incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HFOV With Intermittent Sigh Breaths in Neonate: CO2 Level
Status: ENROLLING_BY_INVITATION
Conditions: High-Frequency Ventilation
Interventions: DEVICE: HFOV-sigh
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lesion Sterilization And Tissue Repair Versus Zinc Oxide And Eugenol For Treatment of Necrotic Primary Molars
Status: UNKNOWN
Conditions: Necrotic Primary Molars
Interventions: PROCEDURE: Lesion sterilization and tissue repair|PROCEDURE: zinc oxide and eugenol pulpectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Tolerability, Safety and Efficacy of an Adapted Gut Cleansing Solution in Routine Colon Cleansing Prior to Colonoscopies
Status: COMPLETED
Conditions: Colon Cancer
Interventions: DRUG: NRL0706
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Oral Aprepitant and Transdermal Scopolamine for Preventing Postoperative Nausea and Vomiting
Status: COMPLETED
Conditions: Nausea|Vomiting
Interventions: DRUG: Aprepitant|DRUG: Scopolamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Fulvestrant (FASLODEX™) 250 mg and 500 mg in Postmenopausal Women With Oestrogen Receptor Positive Advanced Breast Cancer Progressing or Relapsing After Previous Endocrine Therapy.
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevalence and Seroconversion of COVID-19 in Autoimmune Diseases in Europe
Status: UNKNOWN
Conditions: COVID-19|Systemic Lupus Erythematosus|Sjogren's Syndrome|Axial Spondyloarthritis|Rheumatoid Arthritis|Giant Cell Arteritis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Comparing the Efficacy, Safety and Tolerability of Oral Dydrogesterone 30 mg Daily Versus Crinone 8% Intravaginal Progesterone Gel 90 mg Daily for Luteal Support in In-Vitro Fertilization (LOTUS II)
Status: COMPLETED
Conditions: Female Infertility
Interventions: DRUG: Dydrogesterone 30 mg|DRUG: intravaginal progesterone gel 90 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Rate of Unipolar Polarity Switch for Lesion Assessment in Pulmonary Vein Isolation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: OTHER: Unipolar Polarity Switch Left|OTHER: Unipolar Polarity Switch Right
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: S0701, Trial of Three Antibiotic Regimens to Eradicate Helicobacter Pylori (H. Pylori)
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: PACx14|DRUG: PACMx5|DRUG: PAx5/PCMx5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Ranibizumab for Vitreous Hemorrhage Due to Proliferative Diabetic Retinopathy (N)
Status: COMPLETED
Conditions: Vitreous Hemorrhage|Proliferative Diabetic Retinopathy
Interventions: DRUG: Ranibizumab|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Building Caregiver Skills Using a Simulation-based Intervention for Care of Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: BEHAVIORAL: In-person education sessions|BEHAVIORAL: NCI Booklet|OTHER: Survey|OTHER: Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body
Status: RECRUITING
Conditions: Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion
Interventions: DRUG: larotrectinib(Vitrakvi, BAY2757556)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Find Out How Long it Takes Azelastine Hydrochloride 0.15% Nasal Spray to Relieve Symptoms in Patients Suffering From Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Azelastine hydrochloride (BAYR9258)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy and Pharmacokinetics of BTA-C585 in a RSV Viral Challenge Study
Status: COMPLETED
Conditions: Respiratory Syncytial Virus (RSV) Infection
Interventions: DRUG: BTA-C585 oral capsule|DRUG: Matching placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Defining PET / CT Protocols With Optimized F18-FDG (Fluorodeoxyglucose) Dose, Focusing on Reduced Radiation Dose and Improved Image Quality
Status: COMPLETED
Conditions: Malignant Neoplasm of Breast|Hodgkin Disease|Non-Hodgkin Lymphoma, Follicular (Nodular)|Malignant Neoplasm of Bronchus and Lung|Malignant Neoplasm of Colon|Secondary Neoplasm Malignant and Unspecified Lymph Nodes|Malignant Melanoma of the Skin|Malignant Neoplasm of Small Intestine
Interventions: OTHER: Image quantify
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Tolerance of Flucortac in Patients With Orthostatic Neurogenic Hypotension
Status: RECRUITING
Conditions: Neurogenic Orthostatic Hypotension
Interventions: DRUG: Fludrocortisone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine-Related Pain in Infants
Status: COMPLETED
Conditions: Pain
Interventions: OTHER: Manual Pressure|OTHER: Rapid Injection without Aspiration|OTHER: Manual Pressure + Rapid Injection without Aspiration|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Varenicline (Champix) for Smoking Cessation/Reduction in Patients With Bipolar Disorder
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: DRUG: varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Brief Appetite Awareness Intervention for Eating and Weight Regulation Among College Freshmen
Status: COMPLETED
Conditions: Obesity|Eating Disorders
Interventions: BEHAVIORAL: Appetite Awareness|BEHAVIORAL: Nutrition Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TMJ Adaptations by Orthodontic Treatment in Adolescent Females With Angle's Class II Division 2 Malocclusion: MRI Study
Status: COMPLETED
Conditions: Class II Division 2 Malocclusion
Interventions: PROCEDURE: orthodontic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of NAC on Lung Function and CT Mucus Score
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: n-acetylcystine + albuterol|DRUG: 0.9% saline + albuterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postpartum Pre-exposure Prophylaxis (PrEP) Study to Evaluate an Adherence Promotion Package for Postpartum Women on PrEP
Status: COMPLETED
Conditions: HIV-1-infection
Interventions: BEHAVIORAL: HIVST and enhanced adherence biofeedback|DIAGNOSTIC_TEST: Orasure/UrSure test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial To Assess The Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of Single Doses Of PF-04937319 In Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Placebo|DRUG: PF-04937319
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: CCR2 PET for Pancreatic Cancer Imaging and Prediction of Response to Standard and CCR2-Targeted Therapy
Status: RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: 64Cu-DOTA-ECLIi|DEVICE: PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cabazitaxel, Carboplatin, and Cetrelimab Followed by Niraparib With or Without Cetrelimab for the Treatment of Aggressive Variant Metastatic Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Aggressive Variant Prostate Carcinoma|Castration-Resistant Prostate Carcinoma|Metastatic Prostate Carcinoma|Metastatic Prostate Neuroendocrine Carcinoma|Metastatic Prostate Small Cell Carcinoma|Stage IV Prostate Cancer AJCC v8
Interventions: DRUG: Cabazitaxel|DRUG: Carboplatin|BIOLOGICAL: Cetrelimab|DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evolution of HIV Reservoir, Inflammation and Microbiota Footprint of PLWH Switching to Long-acting Injectable Treatment Compared to Patients on Oral Dual or Triple Anti-integrase-based Therapy
Status: UNKNOWN
Conditions: HIV Infections
Interventions: OTHER: Stool sampling|OTHER: Blood plasma collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Markers of Liver Apoptosis After Anesthesia With Sevoflurane or Propofol
Status: COMPLETED
Conditions: Liver Dysfunction
Interventions: DRUG: Sevoflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Oral Ibandronate in Patients of Liver Cirrhosis With Hepatic Osteodystrophy.
Status: NOT_YET_RECRUITING
Conditions: Hepatic Osteodystrophy|Liver Cirrhosis
Interventions: DRUG: Ibandronate|DRUG: Calcium|DRUG: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Supplementation With Vitamin D to Patients With Heart Failure (D-Heart).
Status: UNKNOWN
Conditions: Heart Failure With Reduced Ejection Fraction|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Wellbeing, Stress Reduction and Social Cognition
Status: COMPLETED
Conditions: Cognitive Function 1, Social
Interventions: BEHAVIORAL: Active Comparator: Program 1|BEHAVIORAL: Active Comparator: Program 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure
Status: NOT_YET_RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: DEVICE: Synchronized Diaphragmatic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Various Formulations of Live Attenuated Tetravalent Dengue Vaccine in Healthy US Adults
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: Pre-transfection F17|BIOLOGICAL: Post-transfection F17|BIOLOGICAL: Post-transfection F19|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 3 Study to Investigate the Efficacy and Safety of SHR0302 With Moderately to Severely Active Ulcerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: SHR0302|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrative Approach to Identify Environmental Risk Factors for CC-17 Group B Streptococcal Neonatal Infection
Status: COMPLETED
Conditions: Vaginal Colonization With GBS
Interventions: BIOLOGICAL: Bacteriological analyses on clinical samples performed with Eswabs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effect of Compliance Counseling on Brace Success in Patients With Idiopathic Scoliosis
Status: COMPLETED
Conditions: Adolescent Idiopathic Scoliosis
Interventions: OTHER: Counseled cohort
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Safety and Immunogenicity of a Multivalent Pneumococcal Conjugate Vaccine in Adults 60 Through 64 Years of Age
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: Multivalent|BIOLOGICAL: Prevnar 13|BIOLOGICAL: PPSV23|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: HPV-16 Vaccination and Pembrolizumab Plus Cisplatin for "Intermediate Risk" HPV-16-associated Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: HPV-Related Squamous Cell Carcinoma|Head and Neck Squamous Cell Carcinoma
Interventions: RADIATION: IMRT (Intensity Modulated Radiotherapy)|DRUG: Pembrolizumab|DRUG: Cisplatin|BIOLOGICAL: ISA101b
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ED50 of Dexmedetomidine to Prevent Emergence Agitation in Children
Status: UNKNOWN
Conditions: Agitation
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of (Surgery and Endoscopy) in Management of Indeterminate Common Bile Duct Stricture
Status: UNKNOWN
Conditions: Indeterminate Common Bile Duct Stricture
Interventions: PROCEDURE: endoscopy or surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Gastrointestinal Tolerance of a Nutritional Supplement in Adult Patients With or at Risk of Malnutrition
Status: COMPLETED
Conditions: Gastro-Intestinal Tolerance
Interventions: OTHER: High Protein, Energy Dense Nutritional Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Low-level Laser Therapy and Static Stretching in Knee Osteoarthritis.
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Active Laser|OTHER: Stretching exercises|DEVICE: placebo laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Intermediate Risk Prostate Cancer Imaging
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: 68Ga-PSMA-617 PET/CT|DRUG: 68Ga-RM2 PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study of TCD601 Compared to ATG in de Novo Renal Transplantation
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Transplantation
Interventions: BIOLOGICAL: TCD601|DRUG: Tacrolimus (TAC)|DRUG: Corticosteroids (CS)|DRUG: Mycophenolate Mofetil (MMF)|DRUG: ATG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reducing the Risk of Phlebitis From Peripheral Venous Catheter
Status: COMPLETED
Conditions: Phlebitis
Interventions: BEHAVIORAL: Evaluation of the Effect of Proximal Massage and Fist Clenching in Reducing the Risk of Phlebitis From Peripheral Venous Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study Comparing Pemetrexed Plus Cisplatin Versus Pemetrexed Alone in NSCLC Patients Who Have Progressed on First Line EGFR-TKI
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Cisplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Clinical Trial to Investigate the Pharmacokinetics and Safety/Tolerability of CKD-375
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: CKD-375|DRUG: D387
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetuximab, Leucovorin, Oxaliplatin, and Fluorouracil With or Without Bevacizumab in Treating Patients With Resectable Liver Metastases From Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: BIOLOGICAL: bevacizumab|BIOLOGICAL: cetuximab|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sodium Bicarbonate in Cardiopulmonary Resuscitation
Status: UNKNOWN
Conditions: Sudden Cardiac Arrest
Interventions: DRUG: sodium bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-lesional ACE Inhibitor for Treatment of Hypertrophic Scars
Status: NOT_YET_RECRUITING
Conditions: Hypertrophic Scar
Interventions: DRUG: Intralesional enalaprilat injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrated Hyperglycaemia Incentivised Postnatal Surveillance Study (I-HIPS)
Status: RECRUITING
Conditions: Gestational Diabetes|Glucose Metabolism Disorders|Metabolic Disease
Interventions: DEVICE: Wearable Care Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Three Meshes in Lichtenstein Hernia Repair
Status: COMPLETED
Conditions: Chronic Pain|Recurrences
Interventions: DEVICE: Vypro II mesh|DEVICE: Premilene LP|DEVICE: Premilene mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: REal World Assessment for Patients Implanted With Implantable CardioverTer DefibrIllatOr Using Bluetooth Technology
Status: RECRUITING
Conditions: Cardiac Arrhythmias|Sudden Cardiac Death|Heart Failure
Interventions: DEVICE: smartphone APP based remote monitoring|DEVICE: bedside transmitter based remote monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Development of a Polyphenol-rich Dietary Preparation for Treating Veterans With Gulf War Illness
Status: COMPLETED
Conditions: Gulf War Illness
Interventions: DIETARY_SUPPLEMENT: Concord grape juice|DIETARY_SUPPLEMENT: Placebo Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Registry and Screening Tool to Identify Children With Asthma Likely to Benefit From Home Assessment and Remediation
Status: COMPLETED
Conditions: Asthma|Pediatric ALL|School Health Services|Registries|Medical Informatics|Home Visits|Housing Problems|Social Determinants of Health|Healthcare Disparity|Health Status Disparity
Interventions: OTHER: Home assessment|OTHER: Home remediation|OTHER: Referral to Medical Legal Partnership|OTHER: Regular School Based Health Asthma Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enabling Personalized Medicine Through Exome Sequencing in the U.S. Air Force
Status: COMPLETED
Conditions: Healthy Adults|Genetic Predisposition to Disease
Interventions: GENETIC: Whole exome sequencing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: IntegRAted Chronic Care Program at Specialized AF Clinic Versus Usual CarE in Patients With Atrial Fibrillation - RACE4
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: OTHER: Specialized outpatient AF Clinic|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Non-invasive Stimulation of the Vagus Nerve for the Treatment of Difficult-to-treat Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DEVICE: T-VNS® Stimulator cM02 (Transcutaneous Stimulation of the Vagus Nerve)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Followed by Study of RAD001 in Combination With Trastuzumab in HER2-Positive Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Everolimus|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept in Patients With Generalized Anxiety Disorder (GAD)AZD7325
Status: COMPLETED
Conditions: Anxiety Disorders
Interventions: DRUG: AZD7325|DRUG: AZD7325|DRUG: Lorazepam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Influence of Three Different α-antagonists and Placebo on the Extent of Weekly Phenylephrine-induced Mydriasis at Three Different Concentrations of Phenylephrine in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tamsulosin|DRUG: Alfuzosin|DRUG: Doxazosin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Bilateral, Masked Comparison of PEG-400 Based Artificial Tear and Systane for the Treatment of Dry Eye Signs, Symptoms and Visual Quality
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: PEG-400 based artificial tear|DRUG: Systane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Assess the Long-term Safety and Efficacy of Lacosamide in Subjects With Painful Diabetic Neuropathy
Status: COMPLETED
Conditions: Painful Diabetic Neuropathy
Interventions: DRUG: Lacosamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Taurine on Glycemic Control in Type I and Type II Diabetic Patients
Status: UNKNOWN
Conditions: it is a Group of Metabolic Diseases in|Which a Person Has High Blood Sugar, Either|Because the Body Does Not Produce Enough Insulin,|or Because Cells do Not Respond to the Insulin That|is Produced.
Interventions: DRUG: Taurine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endogenous Progenitors Cell Therapy for Diabetic Foot Ulcers
Status: WITHDRAWN
Conditions: Diabetic Ulcer
Interventions: DRUG: AMD3100 injection + rhPDGF-BB topical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Development of a Robust and Reliable Pulse Oximeter for Children With Pneumonia in Low-income Countries
Status: COMPLETED
Conditions: Pneumonia in Children|Measurement of Peripheral Oxygen Saturation
Interventions: DEVICE: Pulse oximeter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: PENTACON Trial: Partial ENdothelial Trepanation in Addition to Anterior Lamellar Keratoplasty in keratoCONus
Status: TERMINATED
Conditions: Keratoconus
Interventions: PROCEDURE: PET|PROCEDURE: DALK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Detection and Evidence-based Care of NAFLD in Latinx and Black Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: NAFLD|Diabetes Mellitus
Interventions: BEHAVIORAL: NAFLD Education|BEHAVIORAL: diet/lifestyle support|DRUG: T2D medication management|DIAGNOSTIC_TEST: clinically-indicated liver testing and care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Formulation and Food Effect Study of AZD1386 in Healthy Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: AZD1386|DRUG: AZD1386|DRUG: AZD1386
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Clinical Efficacy of Recently Developed Supraglottic Airway Device, I-gel™, in Neonates and Infants: Comparison With Classic-laryngeal Mask Airway (c-LMA)
Status: COMPLETED
Conditions: Airway Complication of Anaesthesia
Interventions: DEVICE: classic-laryngeal mask airway (c-LMA)|DEVICE: i-gel™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Validation and Reproducibility of S.P.A.T. With Allergens
Status: COMPLETED
Conditions: Allergy to House Dust|Allergy Pollen
Interventions: DEVICE: Skin Prick Automated Test|DIAGNOSTIC_TEST: Skin Prick Manual Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Systemic Normothermia in Intracerebral Hemorrhage (ICH)
Status: COMPLETED
Conditions: Intracerebral Hemorrhage
Interventions: DEVICE: Arctic Sun cooling device|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ATI-50002 Topical Solution for the Treatment of Alopecia Areata
Status: TERMINATED
Conditions: Alopecia Areata
Interventions: DRUG: ATI-50002 high dose|DRUG: ATI-50002 low dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Humor Therapy and Rheumatoid Arthritis
Status: COMPLETED
Conditions: Pain|Anxiety|Rheumatoid Arthritis|Nursing Caries
Interventions: OTHER: Supportive care (Watching a comedy movie)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preliminary Safety and Efficacy Study of Extracellular Vesicle Infusion in the Intervention of Age-related Phenotypes With Impaired Glucose Tolerance.
Status: NOT_YET_RECRUITING
Conditions: Impaired Glucose Tolerance
Interventions: BIOLOGICAL: Intravenous infusion of extracellular vesicle preparation derived from Wharton's jelly mesenchymal stem cells.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heart Rate Variability Biofeedback for Smoking Cessation
Status: COMPLETED
Conditions: Tobacco Smoking
Interventions: BEHAVIORAL: Cognitive-Behavioral Smoking Cessation|BEHAVIORAL: Heart Rate Variability Biofeedback (HRVB)|DRUG: Transdermal Nicotine patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab EfFicacy IN MyasthEnia Gravis (REFINE)
Status: RECRUITING
Conditions: Myasthenia Gravis, Generalized
Interventions: DRUG: Rituximab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Cost Management of Multicolumn Spinal Cord Stimulation in Neuropathic Pain Patients With Failed Back Surgery Syndrome
Status: COMPLETED
Conditions: Failed Back Surgery Syndrome
Interventions: DEVICE: comparison of spinal cord stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PRoGReSS-PS: Patient Response to GRraded Sensory Stimulation: A Pilot Study
Status: COMPLETED
Conditions: Low Back Pain
Interventions: PROCEDURE: Spinal treatment|PROCEDURE: Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bipolar Versus Unipolar Hemiarthroplasty for Patients With a Hip Fracture
Status: WITHDRAWN
Conditions: Femoral Neck Fractures
Interventions: PROCEDURE: Unipolar Hemiarthroplasty of the hip joint|PROCEDURE: bipolar hemiarthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on the Effectiveness of AI-assisted Colonoscopy in Improving the Effect of Colonoscopy Training for Trainees
Status: UNKNOWN
Conditions: Colonoscopy|Artificial Intelligence|Gastrointestinal Disease
Interventions: DEVICE: artificial intelligence assistance system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC