pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: An Open-label Study of Encorafenib + Binimetinib in Patients With BRAFV600-mutant Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: encorafenib|DRUG: binimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Web Based Orthopaedic Sports Medicine Registry
Status: TERMINATED
Conditions: Degenerative and Traumatic Pathology of the Knee|Degenerative and Traumatic Pathology of the Shoulder and Elbow|Degenerative and Traumatic Pathology of the Foot and Ankle|Degenerative and Traumatic Pathology of the Hand and Wrist|Degenerative and Traumatic Pathology of the Hip
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Monitor-Guided Analgesia During General Anesthesia - Part I
Status: COMPLETED
Conditions: Pain|Pain, Postoperative|Nociceptive Pain|Opioid Use|Analgesia
Interventions: PROCEDURE: Opioid administration in intervention groups|PROCEDURE: Opioid administration in control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Lenvatinib in Combination With Everolimus in Recurrent and Refractory Pediatric Solid Tumors, Including Central Nervous System Tumors
Status: COMPLETED
Conditions: Recurrent and Refractory Solid Tumors
Interventions: DRUG: Lenvatinib|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irinotecan, Fluorouracil, Leucovorin, and Oxaliplatin as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: fluorouracil|DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-centered Development of the Cancer Support Community's Open to Options ®Chatbot Program
Status: TERMINATED
Conditions: Cancer
Interventions: BEHAVIORAL: Online Survey|BEHAVIORAL: Chatbot prototype|BEHAVIORAL: Open to Options (O2O) Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Rivaroxaban for Children With Giant Coronary Artery Aneurysms After Kawasaki Disease
Status: NOT_YET_RECRUITING
Conditions: Kawasaki Disease|Coronary Artery Aneurysm
Interventions: DRUG: Rivaroxaban Oral Tablet [Xarelto]|DRUG: Aspirin or Clopidogrel|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comprehensive Police Fatigue Management Program
Status: COMPLETED
Conditions: Sleep Disorders|Sleep Apnea, Obstructive|Restless Legs Syndrome|Sleep Disorders, Circadian Rhythm|Sleep Initiation and Maintenance Disorders
Interventions: BEHAVIORAL: Sleep Hygiene Education|OTHER: Expert-Led Sleep Disorders Screening and Treatment|OTHER: Online Sleep Disorders Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Study on the Efficacy and Safety of Microwave Ablation and Lobectomy in the Treatment of Ground Glass Nodules Located in the Pulmonary Hilar Region
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Nodule, Multiple|Pulmonary Nodule, Solitary
Interventions: PROCEDURE: microwave ablation|PROCEDURE: lobectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: De-escalation Study for Stage IIa/IIb < 3 cm Seminoma
Status: RECRUITING
Conditions: Seminoma|Stage II
Interventions: RADIATION: Radiotherapy boost|DRUG: Carboplatin AUC7|DRUG: 3 cycles of EP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of First-line Maintenance Erlotinib Versus Erlotinib at Disease Progression in Participants With Advanced Non-Small Cell Lung Cancer (NSCLC) Who Have Not Progressed Following Platinum-Based Chemotherapy
Status: COMPLETED
Conditions: Non-Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: Placebo|DRUG: Erlotinib|DRUG: Second-Line Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Intermediate Risk Recurrent Non-muscle Invasive Bladder Cancer (NMIBC)
Status: TERMINATED
Conditions: Non-muscle Invasive Bladder Cancer (NMIBC)
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention for Symptom Burden During Maintenance Therapy for Multiple Myeloma
Status: COMPLETED
Conditions: Myeloma
Interventions: DRUG: Minocycline|OTHER: Placebo|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tangningtongluo Tablet for People With Prediabetes
Status: UNKNOWN
Conditions: Prediabetes
Interventions: DRUG: Tangningtongluo tablet|BEHAVIORAL: lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Adherence & Associated Factors in Teenagers Undergoing Treatment of Acne Vulgaris With Differin® Gel 0.1%
Status: COMPLETED
Conditions: Acne
Interventions: OTHER: More frequent than normal office visits|OTHER: Electronic reminders (voice, e-mail, text messages)|OTHER: Parenteral involvement / intervention reminders|OTHER: No intervention or reminders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cytochlor and Tetrahydrouridine as Radiosensitizers and Cisplatin Combined With Radiation Therapy in Treating Patients With Advanced Squamous Cell Carcinoma of the Oral Cavity (Mouth) or Oropharynx (Throat)
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: cisplatin|DRUG: cytochlor|DRUG: tetrahydrouridine|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Copper Cu 64 PSMA I&T PET Imaging in Men With Newly Diagnosed Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer|Prostate Adenocarcinoma
Interventions: DRUG: Copper Cu 64 PSMA I&T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Loop-tip Cook Medical® Wire Versus Traditional Endoscopic Technique
Status: COMPLETED
Conditions: Complications of Surgical and Medical Care: General Terms
Interventions: DEVICE: ERCP with loop tip wire|DEVICE: ERCP for cannulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: EMDR Treatment in PTSD Following Cardiac Events
Status: RECRUITING
Conditions: Posttraumatic Stress Disorder|Myocardial Infarction|Eye Movement Desensitization and Reprocessing
Interventions: BEHAVIORAL: EMDR Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Individually Targeted Neuromodulation for Contamination-based OCD
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: cTBS|DEVICE: iTBS|DEVICE: sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dates and Castor Oil on the Initiation of Spontaneous Labor in Primigravida Parturients
Status: UNKNOWN
Conditions: Effect of Dates and Castor Oil on Spontaneous Labor
Interventions: DIETARY_SUPPLEMENT: Dates|DIETARY_SUPPLEMENT: Castor oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ADjuVant Apatinib in Nasopharyngeal Carcinoma Patients With Residual Epstein-Barr Virus (EBV) DNA Following Radiotherapy
Status: TERMINATED
Conditions: Nasopharyngeal Neoplasms
Interventions: DRUG: Apatinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Diamel in Patients With Nonalcoholic Steatohepatitis
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis|Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: Diamel|OTHER: Placebo and lifestyle counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Implant Surface Decontamination on the Reconstructive Outcomes of Peri-implantitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Peri-Implantitis
Interventions: DEVICE: Surface decontamination procedure aiming at reconstructive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cerebrolysin Compared to Donepezil in Patients With Mild to Moderate Dementia of Alzheimer's Type (DAT)
Status: WITHDRAWN
Conditions: Alzheimer Disease
Interventions: DRUG: Cerebrolysin|DRUG: Donepezil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Beneficial Effect of Vitamin D Supplement to Peg Interferon Alpha 2a or to Telbivudine Monotherapy in Patients With Chronic Hepatitis B Virus (HBV) Infection
Status: UNKNOWN
Conditions: Hepatitis B Virus
Interventions: DRUG: Peginterferon + Vitamin D|DRUG: Peginterferon|DRUG: Sebivo|DRUG: entecavir+ vitamin d
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Effect of Deodorant and Axillary Hair on Testosterone Absorption in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Testosterone|OTHER: Deodorant Spray|OTHER: Deodorant and Antiperspirant Combination Spray|OTHER: Deodorant and Antiperspirant Combination Stick
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Optimizing the Assessment of Refractive Outcomes After Cataract Surgery
Status: COMPLETED
Conditions: Cataract
Interventions: PROCEDURE: Manifest refraction|DEVICE: ACRYSOF® IQ Monofocal IOL Model SN60WF|DEVICE: Topcon® KR-1W Wave-Front Analyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Preliminary Evidence of Efficacy of Escalating Doses of Dimiracetam in AIDS Patients With Painful Neuropathy
Status: COMPLETED
Conditions: Neuropathy|AIDS
Interventions: DRUG: dimiracetam|DRUG: sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Research Study on How Semaglutide Works in People With Fatty Liver Disease and Liver Damage
Status: COMPLETED
Conditions: Non-alcoholic Steatohepatitis
Interventions: DRUG: Semaglutide|DRUG: Placebo (semaglutide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of a Tool for the Dimensional Assessment of Apathy in a Population Suffering From Schizophrenia.
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DIAGNOSTIC_TEST: Validate according to psychometric criteria, a dimensional measure of apathy in a population suffering from schizophrenia spectrum disorder and other psychotic disorders (according to DSM-5 criteria).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety/Efficacy Study of LDE225 (Sonidegib) Plus Bortezomib in Patients With Relapsed or Relapsed/Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: LDE225|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulsed Dye Laser and Intense Pulsed Light Configured With Different Wavelength Bands in Improving Erythematotelangiectatic Rosacea
Status: UNKNOWN
Conditions: Erythematotelangiectatic Rosacea
Interventions: DEVICE: PDL(595nm)|DEVICE: IPL(DPL)|DEVICE: IPL(M22 590)|DEVICE: IPL(M22 vascular)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Home-Delivered Neurostimulation for Migraine
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: DEVICE: non-invasive transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine, Cisplatin, and Gefitinib in Treating Patients Who Are Undergoing Surgery for Stage III Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: gefitinib|DRUG: gemcitabine hydrochloride|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodality Risk Adapted Tx Including Induction Chemo for SCCHN Amenable to Transoral Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer|Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Lapatinib|DRUG: Cisplatin|DRUG: Cisplatin|RADIATION: Ipsilateral Radiation|RADIATION: Bilateral Radiation|PROCEDURE: Transoral Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Compare the Pharmacokinetics of Fimasartan/Amlodipine Combination Tablet and Coadministration of Fimasartan and Amlodipine as Individual Tablets
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Fimasartan|DRUG: Amlodipine|DRUG: Fimasartan/Amlodipine combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Relaxation for Women With Breast Cancer Undergoing Radiotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: OTHER: Relaxation Program|BEHAVIORAL: Questionnaires|OTHER: Saliva Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Efficacy of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Unilateral Neglect in Patients With Subacute-Chronic Phase After Ischemic Stroke
Status: RECRUITING
Conditions: Neglect, Hemispatial
Interventions: DEVICE: Active Repetitive Transcranial Magnetic Stimulation|DEVICE: Sham Repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men to Find the Best Formulation for Once Daily Intake of Nintedanib
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ofev®|DRUG: Nintedanib formulation 1|DRUG: Nintedanib formulation 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Carotid Ultrasound-guided Fluid Management on Anesthetic-induced Hypotension in Elderly Patients Undergoing Gastrointestinal Surgery
Status: RECRUITING
Conditions: Hypotension on Induction
Interventions: OTHER: Fluid therapy under the guide of Carotid ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: EDoF IOLs vs Monofocal IOL
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: EDoF1|DEVICE: Monofocal|DEVICE: EDoF2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy With or Without Chemotherapy in Patients With Stage I-IIA Cervical Cancer Who Previously Underwent Surgery
Status: UNKNOWN
Conditions: Cervical Adenocarcinoma|Cervical Adenosquamous Carcinoma|Cervical Squamous Cell Carcinoma, Not Otherwise Specified|Stage I Cervical Cancer AJCC v6 and v7|Stage IA Cervical Cancer AJCC v6 and v7|Stage IB Cervical Cancer AJCC v6 and v7|Stage IIA Cervical Cancer AJCC v7
Interventions: DRUG: Cisplatin|RADIATION: External Beam Radiation Therapy|RADIATION: Intensity-Modulated Radiation Therapy|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tunnel Widening in Augmented ACL Integration Via PrP Enriched Collected Autologous Bone vs Standard ACL Technique
Status: RECRUITING
Conditions: Anterior Cruciate Ligament Tear
Interventions: PROCEDURE: ACL reconstruction with bone/PrP-composite|PROCEDURE: ACL reconstruction (Standard)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Restoring Spindle and Thalamocortical Efficiency in Early-Course Schizophrenia Patients Using Auditory Stimulation
Status: RECRUITING
Conditions: Schizophrenia
Interventions: DEVICE: Closed-loop auditory stimulation|DEVICE: Sham auditory stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility of Prophylactic Haldol to Prevent Delirium in Cancer Patients
Status: COMPLETED
Conditions: Stem Cell Transplant Complications|Delirium
Interventions: DRUG: Haldol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Children With Autism Spectrum Disorders and Epileptiform EEG With Divalproex Sodium
Status: WITHDRAWN
Conditions: Autism
Interventions: DRUG: divalproex sodium|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of DWKH
Status: COMPLETED
Conditions: Respiratory Infection
Interventions: DRUG: DWKH|DRUG: DWKH-R|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Thread Length on Implant Stability
Status: COMPLETED
Conditions: Implant Stability
Interventions: DEVICE: Implants with 0,7 mm threads|DEVICE: Implants with 0.3 mm threads
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pyrotinib Plus Capecitabine in Patients With Brain Metastases From HER2-positive Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: HER2 Positive Metastatic Breast Cancer
Interventions: DRUG: Pyrotinib plus Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy & Safety Study of BMS-512148 in Combination With Metformin Extended Release Tablets
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Dapagliflozin|DRUG: Metformin XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of Zirconia Reinforced GI Versus Conventional Viscous GI in Geriatric Patients
Status: COMPLETED
Conditions: Geriatric|Performance
Interventions: DRUG: Zirconomer Improved|DRUG: Ketac Molar quick Aplicap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: WeExPAnd: PrEP Demonstration Project Among Women at Risk for HIV Infection - Preexposure Prophylaxis (PrEP)
Status: ENROLLING_BY_INVITATION
Conditions: HIV-infection/AIDS
Interventions: BEHAVIORAL: Cultural adaptation of a patient-provider communication tool
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Baricitinib Compared to Standard Therapy in Patients With COVID-19
Status: UNKNOWN
Conditions: Covid-19|SARS-CoV 2|SARS Pneumonia
Interventions: DRUG: Baricitinib Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multiple Ascending Dose Study With AZD9164 Given for 13 Days in Healthy Male and Female Subjects and in Patients With Chronic Obstructive Pulmonary Disease
Status: TERMINATED
Conditions: Healthy|COPD
Interventions: DRUG: AZD9164 Turbuhaler®|DRUG: Placebo Turbuhaler®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Nasal Irrigation With Respimer® Netiflow® vs Saline Among Patients With Cystic Fibrosis and Chronic Rhinosinusitis
Status: UNKNOWN
Conditions: Chronic Rhinosinusitis|Cystic Fibrosis
Interventions: OTHER: Saline solution|OTHER: Respimer Netiflow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cyclosporine 0.1% Eye Drops as Prophylactic Treatment In Cataract Surgery
Status: COMPLETED
Conditions: Ocular Surface Disease|Ocular Inflammation
Interventions: DRUG: CycloSPORINE Ophthalmic 0.1% Ophthalmic Emulsion|DEVICE: cationorm eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma|Gliosarcoma|Supratentorial Glioblastoma
Interventions: DRUG: Mefloquine|DRUG: Memantine Hydrochloride|DRUG: Metformin Hydrochloride|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Digital Platform in Engagement and Prognosis of Patients in an Early Intervention Pychosis Programme
Status: NOT_YET_RECRUITING
Conditions: Device Adherence
Interventions: DEVICE: PIPPEP App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Automated Phonocardiography Analysis in Adults
Status: COMPLETED
Conditions: Aortic Insufficiency|Aortic Stenosis|Mitral Insufficiency|Mitral Insufficiency and Aortic Stenosis|Tricuspid Regurgitation|Insufficiency, Pulmonary|Insufficiency, Tricuspid
Interventions: DEVICE: Automated Heart Murmur Detection AI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: rTMS With and Without iCBT For the Treatment of Resistant Depression (TRD)
Status: COMPLETED
Conditions: Depressive Disorder, Treatment-Resistant
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)|OTHER: Internet-Delivered Cognitive Behavior Therapy (iCBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan Plus Temozolomide in Treating Patients With Recurrent Primary Malignant Glioma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: irinotecan hydrochloride|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Sport as Therapy: a 6-months Lifestyle-Intervention for Patients With Coronary Artery Disease and/or Diabetes
Status: UNKNOWN
Conditions: Exercise Training|Coronary Artery Disease|Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: MSP3-CRM-Vac4All/ Alhydrogel® Malaria Vaccine
Status: ACTIVE_NOT_RECRUITING
Conditions: Malaria,Falciparum
Interventions: BIOLOGICAL: MSP3-CRM-Vac4All/ Alhydrogel®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Benefits of Individualized Advice Administration on Quality of Sleep for the Elderly Living at Home
Status: COMPLETED
Conditions: Sleep Disorder|Complaint, Subjective Health
Interventions: BEHAVIORAL: Pittsburgh Sleep Quality Index|BEHAVIORAL: Sleep diary|BEHAVIORAL: Katz Index of Independence in Activities of Daily Living|BEHAVIORAL: Lawton Instrumental Activities of Daily Living|BEHAVIORAL: Neuropsychiatric Inventory (Cummings)|BEHAVIORAL: Mini Zarit Caregiver Burden Scale, for the caregiver|BEHAVIORAL: Mini Mental state examination|BEHAVIORAL: Cornell Scale for Depression in Dementia|BEHAVIORAL: Quality of Life in Alzheimer's Disease
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Telephone-Delivered Exercise for Multiple Sclerosis Fatigue
Status: COMPLETED
Conditions: Multiple Sclerosis|Fatigue|Physical Activity
Interventions: BEHAVIORAL: Telephone-Delivered Exercise Therapy|BEHAVIORAL: In-Person Delivered Exercise Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine, Ketamine and Dexmetedomidine-Ketamine Combination for Control of Shivering During Regional Anaethesia
Status: COMPLETED
Conditions: Shivering
Interventions: DRUG: Dexmedetomidine|DRUG: ketamine|DRUG: Dexmetedomidine+Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Botox, Dry Needling, Pharmacological Treatment, and Manual Therapy for Bruxism-Induced Myalgia
Status: COMPLETED
Conditions: Myalgia|Bruxism|Quality of Life
Interventions: DRUG: Botulinum toxin|PROCEDURE: Dry needling|DRUG: Myorel|PROCEDURE: Manual therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Amifostine Plus Chemotherapy and Radiation Therapy in Treating Patients With Advanced, Unresectable Head and Neck Cancer
Status: UNKNOWN
Conditions: Drug/Agent Toxicity by Tissue/Organ|Head and Neck Cancer|Radiation Toxicity
Interventions: DRUG: amifostine trihydrate|DRUG: cisplatin|DRUG: paclitaxel|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Health Impacts of Sustainable Ingredient Selection in the Food and Drink Industry - ALTERNATIVE PROTEIN STUDY
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Fava bean, Lupin, Beef meat, Green pea, Hemp, Buckwheat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial of Tadalafil and Glycemic Traits
Status: COMPLETED
Conditions: Cardiovascular Disease|Insulin Resistance|Glucose Intolerance|Obesity
Interventions: DRUG: Tadalafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Posiphen® Dose-Finding, Biomarker Study in Early Alzheimer's and Parkinson's Patients
Status: COMPLETED
Conditions: Alzheimer Disease|Parkinson Disease
Interventions: DRUG: Posiphen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter, Prospective, Rand, PK Study of LCP-Tacro™ Compared to Prograf® Capsules in De Novo Adult Kidney Transplant
Status: COMPLETED
Conditions: Renal Failure
Interventions: DRUG: LCP-Tacro tablets|DRUG: Prograf
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Pain Management for Total Shoulder Arthroplasty: A Pilot Non-Inferiority Trial
Status: NOT_YET_RECRUITING
Conditions: Shoulder Arthritis|Anesthesia, Local|Local Infiltration
Interventions: DRUG: 100 mL of 0.9% normal saline (57ml), 0.5% ropivacaine (40 ml), 10 mg morphine (10 mg/ml), 0.1 mg of epinephrine (0.1 mg/ml), and 30 mg of ketorolac (30 mg/ml)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of FCX-007 for Recessive Dystrophic Epidermolysis Bullosa (RDEB)
Status: TERMINATED
Conditions: Epidermolysis Bullosa Dystrophica, Recessive
Interventions: GENETIC: FCX-007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile Health to Promote Physical Activity Post Stroke
Status: COMPLETED
Conditions: Stroke|Transient Ischemic Attack
Interventions: BEHAVIORAL: Mobile health-delivered physical exercise and support for physical activity|BEHAVIORAL: Mobile health-delivered behavior change techniques.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Post-Myocardial Infarction Remodeling Prevention Therapy
Status: COMPLETED
Conditions: Acute Myocardial Infarction|Pacing Therapy|Cardiac Remodeling|Heart Failure
Interventions: DEVICE: Single Site Pacing|DEVICE: Dual Site Pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Atomoxetine's Effects On Nicotine Response And Stress Response In Smokers
Status: WITHDRAWN
Conditions: Nicotine Dependence
Interventions: DRUG: Atomoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hair Cortisol in Asthma or Allergic Rhinitis Treated With Topical Corticosteroids
Status: UNKNOWN
Conditions: ASTHMA|ALLERGIC RHINITIS
Interventions: DRUG: Treatment with any inhaled corticosteroid|DRUG: Treatment with any intranasal glucocorticoid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate the Pharmacokinetic Characteristics, Safety, Tolerability, and Preliminary Efficacy of 9MW1911 in Patients With Chronic Obstructive Pulmonary Disease (COPD).
Status: RECRUITING
Conditions: Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: 9MW1911|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ToRsemide for pOstpartum HYpertension
Status: COMPLETED
Conditions: Preeclampsia
Interventions: DRUG: Torsemide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Randomized Controlled Trial of Modified Ischial Spinous Fascia Fixation and Sacrospinous Ligament Fixation in the Treatment of Pelvic Organ Prolapse
Status: NOT_YET_RECRUITING
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: sacrospinous ligament fixation (SLFF)|PROCEDURE: modified ischial spinous fascia fixation (modified ISFF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Therapy With Proxalutamide Combined With Androgen Deprivation Therapy（ADT）for High Risk Prostate Cancer
Status: UNKNOWN
Conditions: Neoadjuvant Therapy \High Risk Prostate Cancer
Interventions: OTHER: placebo|DRUG: Proxalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Dose-dense Adriamycin Plus Cytoxan (AC) Followed by Either ABI-007 (Abraxane) or Taxol With Bevacizumab as Adjuvant Therapy for Patients With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Adriamycin and Cytoxan (AC)|DRUG: ABI-007|DRUG: Taxol|DRUG: Bevacizumab|DRUG: pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Meal Tolerance Trial in Pregnant Women Diagnosed With Gestational Diabetes Mellitus.
Status: TERMINATED
Conditions: Gestational Diabetes Mellitus in Pregnancy
Interventions: DIETARY_SUPPLEMENT: Nutritional product|OTHER: Standard breakfast according to ADA recommendations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Efficacy of Association of Senna Alexandrina Mill and Associations on Functional Intestinal Constipation
Status: SUSPENDED
Conditions: Constipation
Interventions: DRUG: Senna alexandrina and associations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Sound Insulation and Music Therapy on the Comfort of Mechanically Ventilated Patients Admitted to Intensive Care Unit
Status: COMPLETED
Conditions: Intensive Care Units
Interventions: BEHAVIORAL: Sound isolation / Music therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PBI-MST-01 (NCT04541108) Substudy AZN-05: Intratumoral Microdosing of Rilvegostomig, Volrustomig, and Sabestomig in HNSCC
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: BIOLOGICAL: Rilvegostomig|BIOLOGICAL: Volrustomig|BIOLOGICAL: Sabestomig|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Intratumoral CAVATAK™ in Patients With Stage IIIc and Stage IV Malignant Melanoma (VLA-007 CALM )
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: BIOLOGICAL: Coxsackievirus A21 (CVA21)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tramadol Simultaneously With Sciatic Nerve Block for Calcaneus Fracture Osteosynthesis
Status: COMPLETED
Conditions: Foot Fracture|Pain, Acute
Interventions: DRUG: Tramadol Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Video Conferencing and In-person Health Coaching on Weight Loss, Physical Activity, and Metabolic Control
Status: COMPLETED
Conditions: Obesity|Weight Loss|Telemedicine
Interventions: BEHAVIORAL: Video Conferencing Group|BEHAVIORAL: In Person Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Subcutaneously Administered Guselkumab for the Treatment of Chronic Plaque Psoriasis in Pediatric Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Psoriasis
Interventions: DRUG: Guselkumab|DRUG: Placebo for guselkumab|DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed Plus Gemcitabine as Front-Line Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer: A Clinical Trial
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Pemetrexed|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eculizumab in Pediatric and Adult Participants With Atypical Hemolytic Uremic Syndrome (aHUS) in China
Status: RECRUITING
Conditions: Atypical Hemolytic Uremic
Interventions: DRUG: Eculizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive-Behavioral Therapy for Irritability in Children With Autism Spectrum Disorder and Intellectual Disability
Status: ENROLLING_BY_INVITATION
Conditions: Autism|Intellectual Disability
Interventions: BEHAVIORAL: Cognitive-Behavioral Therapy|OTHER: Functional magnetic resonance imaging (fMRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GTI-2040 and High-Dose Cytarabine in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Recurrent Adult Acute Myeloid Leukemia
Interventions: BIOLOGICAL: GTI-2040|DRUG: cytarabine|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compassionate Use of Campath-1H in Treating Patients With Refractory Prolymphocytic Leukemia or Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Necrosectomy With Cryotechnology for Accelerated Removal
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Necrosis|Acute Pancreatitis|Acute Pancreatic Necrosis|Necrosis|Necrosis Pancreas|Walled-Off Pancreatic Necrosis
Interventions: DEVICE: Cryotechnology Necrosectomy Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass
Status: RECRUITING
Conditions: Post-bariatric Surgery
Interventions: DRUG: exendin-(9-39)|DRUG: exendin -(9-39)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Evaluating Strategies to Reduce Mother-to-Child Transmission of HIV Infection in Resource-Limited Countries
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zidovudine (ZDV)|DRUG: Nevirapine (NVP): Antepartum Mothers|DRUG: Emtricitabine-tenofovir disoproxil fumarate (Truvada [TRV]) tail|DRUG: Lamivudine-Zidovudine (3TC-ZDV)|DRUG: Lopinavir-ritonavir (LPV-RTV)|DRUG: Emtricitabine-tenofovir disoproxil fumarate (Truvada [TRV])|DRUG: Nevirapine (NVP): Infant short-course|DRUG: Nevirapine (NVP): Infant extended|OTHER: No Intervention|OTHER: Discontinue triple ARVs|OTHER: Continue triple ARVs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 1b Study of Dato-DXd in Combination With Immunotherapy With or Without Carboplatin in Advanced or Metastatic Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Advanced or Metastatic NSCLC
Interventions: DRUG: Datopotamab deruxtecan|DRUG: Durvalumab|DRUG: Carboplatin|DRUG: AZD2936|DRUG: MEDI5752|DRUG: AZD7789
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Chemoradiation Followed by Chemotherapy for Locally Advanced Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Neoplasms|Adenocarcinoma
Interventions: DRUG: Capecitabine Oxaliplatin|RADIATION: pelvic radiation capecitabine 5-fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Clinical Investigation of Two Hearing Instrument Digital Signal Processing
Status: COMPLETED
Conditions: Hearing Loss
Interventions: DEVICE: Polaris miniRITE BTE|DEVICE: Viron miniRiTE BTE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Treatment Factors in the Management of Chronic Iliotibial Band Syndrome in Female Distance Runners
Status: COMPLETED
Conditions: Iliotibial Band Syndrome
Interventions: OTHER: Gluteus medius strengthening|OTHER: iliotibial band stretches
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel and Oxaliplatin Combination With Locally Advanced or Metastatic Biliary Tract Cancer
Status: UNKNOWN
Conditions: Biliary Tract Cancer
Interventions: DRUG: Docetaxel, Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of CRV-101 Vaccine for the Prevention of Herpes Zoster in Adults Aged 50 Years and Older
Status: ACTIVE_NOT_RECRUITING
Conditions: Herpes Zoster|Shingles
Interventions: BIOLOGICAL: CRV-101 Vaccine Antigen High Dose|BIOLOGICAL: CRV-101 Vaccine Antigen Low Dose|BIOLOGICAL: Shingrix|BIOLOGICAL: CRV-101 Vaccine Adjuvant High Dose|BIOLOGICAL: CRV-101 Vaccine Adjuvant Middle Dose|BIOLOGICAL: CRV-101 Vaccine Adjuvant Low Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: DiagNostic Study of Low-dose CT and multipleX PCR on Antibiotic Treatment and Outcome of Community-Acquired Pneumonia
Status: TERMINATED
Conditions: Community-acquired Pneumonia
Interventions: DIAGNOSTIC_TEST: low-dose CT|DIAGNOSTIC_TEST: PoC-PCR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Gestational Diabetes and Antenatal Human Milk Expression
Status: RECRUITING
Conditions: Breastfeeding
Interventions: BEHAVIORAL: Antenatal milk expression and breastfeeding self-efficacy enhancement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Urinary Retention After Vaginal Delivery With Epidural Anesthesia.
Status: RECRUITING
Conditions: Urinary Retention
Interventions: DEVICE: Foley catheter|DEVICE: Short term catheter|DRUG: Epidural anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inflammatory Response Secondary Using Intravenous Anesthesia Versus Inhalation Anesthesia With Halogenated Agents
Status: COMPLETED
Conditions: Pulmonary Resection
Interventions: DRUG: propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Absorption, Metabolism and Excretion of [14C]D-0316 in Human
Status: UNKNOWN
Conditions: Advanced or Metastatic Non-small Cell Lung
Interventions: DRUG: [14C]D-0316 suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Robot-assisted Esophagectomy Versus Conventional Thoracoscopic Esophagectomy
Status: RECRUITING
Conditions: Esophageal Cancer|Esophageal Carcinoma
Interventions: PROCEDURE: esophagectomy|PROCEDURE: esophagectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ADCb (Anlotinib/Docetaxel/Carboplatin) as Neoadjuvant Therapy for Triple-Negative Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOLFOX +/- Ziv-Aflibercept for Esophageal and Gastric Cancer
Status: COMPLETED
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: DRUG: Oxaliplatin|DRUG: Leucovorin|DRUG: Fluorouracil|DRUG: Ziv-aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT