pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Serotonin in Impulse Control Disorders in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease|Impulse Control Disorders
Interventions: DRUG: Positron Emission Tomography using [11 Carbon]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile ([11C]-DASB) and [18 Fluorine]-altanserin ([18F]-altanserin)|DRUG: Positron Emission Tomography using [18 Fluorine]-altanserin ([18F]-altanserin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of AR-67 in Adult Patients With Recurrence of Glioblastoma Multiforme (GBM) or Gliosarcoma
Status: UNKNOWN
Conditions: Glioblastoma Multiforme|GBM|Gliosarcoma
Interventions: DRUG: AR-67 (7-t-butyldimethylsiltyl-10-hydroxy-camptothecin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perfusion and Diffusion Magnetic Resonance Imaging, and Phosphorylation of Circulation Endothelial Cells to Determine Anti-anogenic Effect of Chemotherapeutic Regimens in Colorectal Liver Metastasis Patients
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: PROCEDURE: DCE MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ph1b Study of Oraxol in Comb. w. Ramucirumab in Patients w. Gastric, Gastro-esophageal, or Esophageal Cancers
Status: UNKNOWN
Conditions: Gastric Cancer|Esophageal Cancer|Gastro-esophageal Cancer
Interventions: DRUG: Oraxol|DRUG: Ramucirumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Dyadic Expectations About ARF Survivorship (IDEAS)
Status: RECRUITING
Conditions: Acute Respiratory Failure|Caregiving Stress|Mental Health Issue
Interventions: OTHER: Dyadic expectations about the ARF survivor's perceived health 6 months after hospital discharge|OTHER: Self-efficacy|OTHER: Concordant expectations/shared appraisal of ARF survivor's health 6 months after hospital discharge
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ID-ClimAct. Influence of Social Motives of Clients and Staff on the Social Climate of Secure Settings
Status: NOT_YET_RECRUITING
Conditions: Social Environment|Correctional Institutions|Rehabilitation of Criminals|Social Dominance|Interpersonal Relations
Interventions: DIAGNOSTIC_TEST: CSIV, Social motive|DIAGNOSTIC_TEST: Interpersonal messages and behavior|DIAGNOSTIC_TEST: CCS, Social motive
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Exercise Training on Endothelial Function, Inflammation, Arterial Stiffness and Autonomic Function in CAD
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: OTHER: Exercise-based cardiac rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test BI 765179 Alone and in Combination With Ezabenlimab in Patients With Advanced Cancer (Solid Tumors) and BI 765179 in Combination With Pembrolizumab in Patients With Advanced Head and Neck Cancer
Status: RECRUITING
Conditions: Neoplasms
Interventions: DRUG: BI 765179|DRUG: Ezabenlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-Ventilator Interactions in Chronic Obstructive Pulmonary Diseases (COPD) Under Non-Invasive Ventilation
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Adjustment of ventilator settings (device)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Analyses of Bone Marrow and Blood Samples From Healthy Volunteers: Focus on the redOx Metabolism
Status: COMPLETED
Conditions: redOx Metabolism
Interventions: PROCEDURE: Blood test|PROCEDURE: Medullar test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Retrospective Study to Assess the Outcome After Surgical Reconstruction of the Midfoot With the Midfoot Fusion Bolt in Patients With Neuroarthropathy
Status: COMPLETED
Conditions: Charcot Neuroarthropathy|Diabetic Foot
Interventions: PROCEDURE: MFB
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Adjunctive Metformin on Recurrence of Non-DM Colorectal Cancer Stage II High-risk/ III Colorectal Cancer
Status: UNKNOWN
Conditions: Non-DM Stage II High-risk Colorectal Cancer|Non-DM Stage III Colorectal Cancer
Interventions: DRUG: metformin|DRUG: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Short-term Effect of ELTGOL on Pulmonary Ventilation Valued Through Electrical Impedance Tomography in Cystic Fibrosis Patients
Status: UNKNOWN
Conditions: Cystic Fibrosis
Interventions: OTHER: ELTGOL|DEVICE: Acapella
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cryoablation for the Treatment of Metastatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Malignant Neoplasm
Interventions: PROCEDURE: Core Biopsy|PROCEDURE: Cryosurgery|DRUG: Immunotherapeutic Agent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Utilising Brushing Cytology and Dermoscopy for Diagnosing Penile Lesions
Status: NOT_YET_RECRUITING
Conditions: Penile Cancer
Interventions: DEVICE: Cytological Brushing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioengineered Penile Tissue Constructs for Irreversibly Damaged Penile Corpora
Status: NOT_YET_RECRUITING
Conditions: Urologic Diseases|Male Urogenital Diseases|Penile Diseases|Corpus Callosum Malformation|Corpora Cavernosa; Inflammation|Trauma Injury
Interventions: BIOLOGICAL: Autologous tissue engineered corpora
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Randomized, Double-Blind, Placebo-Controlled Study of 3,4-Diaminopyridine for Demyelinating Polyneuropathy
Status: COMPLETED
Conditions: Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Interventions: DRUG: ,4-diaminopyridine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Fulvestrant Injection 50 mg/mL in Healthy Post-menopausal Female Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Fulvestrant|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of LEO 43204 in the Field Treatment of Actinic Keratosis on Face or Chest including12-month Follow-up
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: LEO 43204 gel|DRUG: Vehicle gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adderall XR and Cognitive Impairment in MS
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: Adderall XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Spectrally Encoded Confocal Microscopy (SECM) to Visualise the Esophagus Using an SECM Probe
Status: COMPLETED
Conditions: Barrett's Esophagus
Interventions: DEVICE: SECM Probe
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study to Compare Welchol and TriCor to TriCor Alone in Patients With High Cholesterol
Status: COMPLETED
Conditions: Hypercholesterolemia|Hyperlipidemia, Familial Combined
Interventions: DRUG: colesevelam HCl tablets and fenofibrate tablets|DRUG: fenofibrate tablets and Welchol placebo tablets|DRUG: fenofibrate tablets and Welchol placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cerebral Autoregulation in Patients With Aneurysmal SubArachnoid Haemorrhage
Status: UNKNOWN
Conditions: Subarachnoid Hemorrhage, Aneurysmal
Interventions: OTHER: Hypertension|OTHER: Hyper- and hypoxia|OTHER: Hyper- and hypocapnia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: BIONICS Small Vessels Trial EluNIR Ridaforolimus Eluting Coronary Stent System (EluNIR) In Coronary Stenosis Trial
Status: COMPLETED
Conditions: Coronary Stenosis|Coronary Disease|Myocardial Ischemia|Cardiovascular Diseases
Interventions: COMBINATION_PRODUCT: EluNIR Ridaforolimus Eluting Coronary Stent System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer
Status: RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Clinical Stage III Gastroesophageal Junction Adenocarcinoma|Clinical Stage IV Gastroesophageal Junction Adenocarcinoma|Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma|Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma A|Locally Advanced Colorectal Carcinoma|Locally Advanced Gastroesophageal Junction Adenocarcinoma|Metastatic Colorectal Adenocarcinoma|Metastatic Gastroesophageal Junction Adenocarcinoma|Pathologic Stage III Gastroesophageal Junction Adenocarcinoma|Pathologic Stage IIIA Gastroesophageal Junction Adenocarcinoma|Pathologic Stage IIIB Gastroesophageal Junction Adenocarcinoma|Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma|Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma|Pathologic Stage IVB Gastroesophageal Junction Adenocarcinoma|Postneoadjuvant Therapy Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8|Stage III Colorectal Cancer AJCC v8|Stage IIIA Colorectal Cancer AJCC v8|Stage IIIB Colorectal Cancer AJCC v8|Stage IIIC Colorectal Cancer AJCC v8|Stage IV Colorectal Cancer AJCC v8|Stage IVA Colorectal Cancer AJCC v8|Stage IVB Colorectal Cancer AJCC v8|Stage IVC Colorectal Cancer AJCC v8
Interventions: DRUG: Trifluridine and Tipiracil Hydrochloride|DRUG: Talazoparib Tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose-escalation Study of AND017 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: AND017 single dose|DRUG: AND017 multiple dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Verbal Suggestion on the Therapeutic Effect of the Joint Manipulation
Status: NOT_YET_RECRUITING
Conditions: Back Pain
Interventions: OTHER: Lumbar manipulation|OTHER: Positive communication - placebo|OTHER: Negative communication - nocebo|OTHER: Neutral communication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Duration of Bismuth Quadruple Therapy for Helicobacter Pylori Eradication in Females as Compared With Males
Status: ENROLLING_BY_INVITATION
Conditions: Helicobacter Pylori Infection|Sex|Bismuth Quadruple Therapy
Interventions: DRUG: Drug: Bismuth Subcitrate 120 MG Oral Tablet|DRUG: Esomeprazole 40mg|DRUG: Metronidazole 250 MG|DRUG: Tetracycline Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Dose-Escalation Study of AZD4785 in Patients With Advanced Solid Tumours
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer|Advanced Solid Tumours
Interventions: DRUG: AZD4785
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence And Food Effect Study Of Bosutinib In Healthy Subjects
Status: COMPLETED
Conditions: Philadelphia Chromosome Positive (Ph+) Chronic Myeloid Leukemia (CML)
Interventions: DRUG: Bosutinib|DRUG: Bosutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Viability and Cardiac Resynchronization Therapy
Status: UNKNOWN
Conditions: Heart Failure|Ischemic Cardiomyopathy
Interventions: DEVICE: AV-optimization followed by AV- and VV-optimization|DEVICE: AV- and VV-optimization followed by AV-optimization only.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Postural Restriction in Treating Benign Paroxysmal Positional Vertigo
Status: UNKNOWN
Conditions: Benign Paroxysmal Positional Vertigo
Interventions: BEHAVIORAL: Postural restriction|BEHAVIORAL: Normal daily activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DECT in Imaging Patients With Solid Organ Cancer With Intracranial Metastasis
Status: COMPLETED
Conditions: Malignant Neoplasm|Metastatic Malignant Neoplasm in the Brain
Interventions: PROCEDURE: Dual-Energy Computed Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I Dose Escalation of i.v. BI 836909 Monotherapy in Last Line Multiple Myeloma Patients
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: BI 836909
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose and Schedule Finding Trial With AMG 531 for Chemotherapy Induced Thrombocytopenia (CIT) in Adults With Lymphoma
Status: COMPLETED
Conditions: Chemotherapy-Induced Thrombocytopenia|Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma|Cancer|Oncology|Thrombocytopenia
Interventions: BIOLOGICAL: AMG 531
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of Cloth Face Coverings as Source Control Under Laboratory and Simulated Field Conditions
Status: COMPLETED
Conditions: Masks
Interventions: OTHER: Flannel mask with ear loops|OTHER: Flannel mask with ties|OTHER: Twill mask with ear loops|OTHER: Twill mask with ties
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: SB-497115 (Oral Thrombopoietin Receptor Agonist) Versus Placebo In Adults With Refractory Immune Thrombocytopenic Purpura (ITP)
Status: COMPLETED
Conditions: Purpura, Thrombocytopaenic, Idiopathic
Interventions: DRUG: SB497115
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study to Assess the Immunogenicity and Safety of Eutravac (DTap-HB Combined Vaccine) With DTaP and Hepatitis B Vaccines in Healthy Infants
Status: COMPLETED
Conditions: Healthy Infants
Interventions: BIOLOGICAL: Eutravac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mindfulness Training Hidradenitis Suppurativa (HS)
Status: RECRUITING
Conditions: Hidradenitis Suppurativa|Quality of Life
Interventions: BEHAVIORAL: Mindfulness Course|BEHAVIORAL: HS Educational Course
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial Evaluating the Safety and Effects of an RNA Vaccine ARCT-021 in Healthy Adults
Status: TERMINATED
Conditions: Covid19|SARS-CoV Infection|Corona Virus Infection
Interventions: BIOLOGICAL: ARCT-021 single dose priming|BIOLOGICAL: ARCT-021 two lower dose priming|BIOLOGICAL: ARCT-021 two higher dose priming|BIOLOGICAL: Placebo (two doses), priming|BIOLOGICAL: Randomized booster|BIOLOGICAL: Placebo booster
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Impact of Telemonitoring in the Management of Hypertension
Status: UNKNOWN
Conditions: Health Services Administration|Telemedicine|Hypertension
Interventions: PROCEDURE: Telemonitoring|PROCEDURE: Usual Care without Telemonitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: NBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 Therapy
Status: RECRUITING
Conditions: Radiotherapy|Immunotherapy|Microsatellite Instability-High Solid Malignant Tumour|Metastasis From Malignant Tumor of Liver|Squamous Cell Carcinoma of Head and Neck|Metastasis From Malignant Tumor of Cervix|Metastatic Renal Cell Carcinoma|Metastasis From Malignant Melanoma of Skin (Disorder)|Metastatic Triple-Negative Breast Carcinoma|Metastatic NSCLC|Metastasis From Malignant Tumor of Bladder (Disorder)
Interventions: DRUG: NBTXR3|RADIATION: SABR|DRUG: Nivolumab|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Cinnamomum Zeylanicum on Glycemic Levels of Adult Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Cinnamomum zeylanicum|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers in Thoracic Aorta Surgery
Status: COMPLETED
Conditions: Aortic Aneurysm|Thoracoabdominal Aneurysm|Aortic Dissection|Complication
Interventions: DIAGNOSTIC_TEST: blood sample tests for determination of biomarkers levels
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Topical Timolol: a Comparison of Surgical Outcomes
Status: UNKNOWN
Conditions: Wound Heal
Interventions: DRUG: Timolol 0.25% Ophthalmic Solution|OTHER: Standard Wound Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trigeminal Ganglion RFT vs Maxillary/Mandibular PRF in the Treatment of Trigeminal Neuralgia
Status: COMPLETED
Conditions: Trigeminal Neuralgia|Headache Disorders
Interventions: PROCEDURE: Radiofrequency thermocoagulation of the trigeminal ganglion|PROCEDURE: Maxillary/Mandibular nerve pulsed radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of AFQ056 in Adolescent Patients With Fragile X Syndrome
Status: COMPLETED
Conditions: Fragile X Syndrome
Interventions: DRUG: AFQ056|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DynaCT in Preoperative Imaging Before Insertion of Stentgraft
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: RADIATION: DynaCT|DRUG: Iodixanol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of a Cilioscleral Interposition Device (CID) SV22 in Patients With Primary Open Angle Glaucoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glaucoma, Open-Angle
Interventions: DEVICE: Interposition supraciliary implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Caffeine Consumption on the Human Circadian System
Status: COMPLETED
Conditions: Caffeine|Caffeine Withdrawal|Sleep|Circadian Rhythm
Interventions: DRUG: Caffeine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dysfunction of Nutritive Blood Flow as a Determinant of Anabolic Resistance With Age; the Role of Amino Acids in Modulating Muscle Metabolism
Status: UNKNOWN
Conditions: Old Age (Focus; Not a Recognized Condition)
Interventions: DIETARY_SUPPLEMENT: 15g EAA bolus|DIETARY_SUPPLEMENT: 4 x 3.75g Mixed EAA Pulses|DIETARY_SUPPLEMENT: 15g EAA Bolus supplemented with 3g Arginine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Glembatumumab Vedotin as Monotherapy or in Combination With Immunotherapies in Patients With Advanced Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: glembatumumab vedotin|DRUG: glembatumumab vedotin and varlilumab|DRUG: glembatumumab vedotin and PD-1 targeted checkpoint inhibitor (nivolumab OR pembrolizumab)|DRUG: glembatumumab vedotin and CDX-301
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LK101 Combined With PD-1 or PD-L1 Monoclonal Antibody in the Treatment of Lung Cancer
Status: RECRUITING
Conditions: Advanced Lung Carcinoma
Interventions: DRUG: LK101 injection (personlized neoantigen pulsed DC vaccine )|DRUG: Pembrolizumab|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploring Acceptance and Outcomes of an Online-based Self-management Support System in Chronic Illness
Status: UNKNOWN
Conditions: Chronic Heart Failure|Diabetes Mellitus|Chronic Obstructive Pulmonary Disease|Special Orthopaedic Co-Morbidity After Hip/Knee Replacement
Interventions: DEVICE: SENACA - ICT based self-management support system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Safety and Efficacy Study of Carboplatin, Paclitaxel, Bevacizumab and CA4P in Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Tumors
Interventions: DRUG: Fosbretabulin|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Etoricoxib With Flavoxate for Reducing Morphine Requirement After Transurethral Prostatectomy (TURP)
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: etoricoxib|DRUG: flavoxate|DRUG: etoricoxib, flavoxate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease
Status: NOT_YET_RECRUITING
Conditions: Peripheral Artery Disease|Peripheral Vascular Diseases|Peripheral Arterial Disease|Peripheral Arterial Occlusive Disease
Interventions: DRUG: Vumerity|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: VideoEndoscopic Radical Inguinal Lymphadenectomy for Penile Cancer
Status: RECRUITING
Conditions: Penile Cancer|Inguinal Lymphadenopathy|Melanoma
Interventions: PROCEDURE: Videoendoscopic radical inguinal lymphadenectomy or open radical inguinal lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Clinical Trial to Evaluate the Effect of IAE0972 in Patients With Advanced Malignant Solid Tumors.
Status: RECRUITING
Conditions: Advanced Malignant Solid Tumor
Interventions: DRUG: IAE0972
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison Between Ivor-Lewis and McKeown Minimally Invasive Esophagectomy
Status: RECRUITING
Conditions: Esophageal Cancer
Interventions: PROCEDURE: MIE Ivor- Lewis|PROCEDURE: MIE McKeown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Safety and Efficacy of FSD-F2R6-A-CP in Volunteers in an Induced State of Alcohol Intoxication
Status: RECRUITING
Conditions: Acute Alcohol Intoxication
Interventions: DIETARY_SUPPLEMENT: FSD-F2R6-A-CP|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: N-Acetyl-L-Leucine for Niemann-Pick Disease, Type C (NPC)
Status: COMPLETED
Conditions: Niemann-Pick Disease, Type C
Interventions: DRUG: IB1001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Australian National Vulvar Cancer Trial
Status: NOT_YET_RECRUITING
Conditions: Vulvar Cancer Stage I|Vulvar Cancer Stage II|Lymph Node Metastasis|Groin Node|Ultrasound Therapy; Complications
Interventions: DIAGNOSTIC_TEST: High-resolution bilateral groin ultrasound monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dyspnea in COPD: Relationship With Exacerbations Frequency
Status: COMPLETED
Conditions: Dyspnea
Interventions: PROCEDURE: Spirometry|PROCEDURE: CO Exhaled breath|PROCEDURE: P01|PROCEDURE: FeNO
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Proof-of-Science, Prospective, Interventional, Three-arm, Double-Blind, Randomized, Safety and Efficacy Real World Evidence Study.
Status: NOT_YET_RECRUITING
Conditions: Hair Fall and Pre-mature Graying
Interventions: OTHER: Polyherbal Hair Oil|OTHER: Minoxidil Herbal Hair Oil + Minoxidil 5 (%) Hair Serum|OTHER: Minoxidil Hair Serum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Factor Xa Inhibitor for Prevention of Venous Thromboembolism in Patients Undergoing Elective Total Knee Replacement
Status: COMPLETED
Conditions: Thromboembolism
Interventions: DRUG: YM150|DRUG: enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Acute Phase Treatment Approaches on Creatine Kinase and the Musculoskeletal System in Different Types of Burns
Status: COMPLETED
Conditions: Burn Injury
Interventions: OTHER: universal goniometer. evaluate the circumference measurement. The biochemical examination of CK (creatine kinase)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Atrofic Striae With Percutaneous Collagen Induction Therapy Versus Fractional Nonablative Laser
Status: COMPLETED
Conditions: Striae Distensae
Interventions: DEVICE: Nd-Yap 1340nm laser|DEVICE: Microneedling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Cardiac Rehabilitation on Sleep Quality and Sleep Duration in Patients After Coronary Artery Bypass Graft
Status: RECRUITING
Conditions: Coronary Artery Disease|Coronary Artery Bypass Graft|Sleep Quality|Cardiac Rehabilitation
Interventions: OTHER: Cardiac rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Vivostat Platelet Rich Fibrin(PRF) in the Treatment of Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot Ulcers
Interventions: DEVICE: Vivostat PRF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Vision After Vivity IOL Implantation With a Target of Slight Myopia in the Non-dominant Eye
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Vivity Extended Depth of Focus intraocular lens (IOL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic Supplementation on Weight Loss
Status: COMPLETED
Conditions: Bariatric Surgery Candidate
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: microcrystalline cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Safety and Efficacy of Oral Etrasimod in Adult Participants With Eosinophilic Esophagitis
Status: COMPLETED
Conditions: Eosinophilic Esophagitis
Interventions: DRUG: Etrasimod|DRUG: Placebo|DRUG: Etrasimod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Macrophage Imaging Using Ga-MMR-VHH2 in Lung Cancer Patients
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: 68GaNOTA-Anti-MMR-VHH2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Efficacy Research of Robot-Assisted Therapy With and Without Constraint-Induced Therapy in Stroke Rehabilitation
Status: COMPLETED
Conditions: Cerebrovascular Accident
Interventions: BEHAVIORAL: Robot-assisted therapy|BEHAVIORAL: Distributed constraint-induced therapy|BEHAVIORAL: Dose-matched control therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Cultural Marginality Theory-Based Education on Intercultural Adaptation and Psychological Well-Being of Foreign Nursing Students
Status: RECRUITING
Conditions: Culture Shock|Adaptation, Emotional|Psychological Well-being
Interventions: OTHER: The Cultural Marginality Theory-Based Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Europe-Africa Research Network for Evaluation of Second-line Therapy
Status: COMPLETED
Conditions: Human Immunodeficiency Virus|HIV
Interventions: DRUG: Aluvia + 2NRTIs|DRUG: Aluvia + raltegravir|DRUG: Aluvia monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psycho-biological Substrates of Therapeutic Benefit of Thermal Cure on Generalized Anxiety Disorders
Status: COMPLETED
Conditions: Generalized Anxious Disorders
Interventions: DRUG: Paroxetine|OTHER: Thermal cure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of EVD Catheter Diameter on Occlusion and Replacement
Status: TERMINATED
Conditions: Occlusion
Interventions: DEVICE: Clear Bactiseal 'large' catheter (EVD)|DEVICE: Orange Bactiseal 'small' catheter (EVD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Follicular Helper T Cells: Biological Marker and Involvement in the Physiopathology of the IgG4-related Disease
Status: COMPLETED
Conditions: IgG4-related Disease
Interventions: BIOLOGICAL: extra blood draw samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bioavailability Study of Clonazepam Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: To Determine Bioequivalence Under Fasting Conditions
Interventions: DRUG: Clonazepam|DRUG: Klonopin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Placebo-controlled Trial in Subjects at Ultra-high Risk for Psychosis With Omega-3 Fatty Acids in Europe
Status: COMPLETED
Conditions: Ultra High Risk for Psychosis
Interventions: DRUG: Omega-3 fatty acids|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Influence of Remifentanil on Postoperative Sore Throat in Patients Undergoing General Anesthesia
Status: COMPLETED
Conditions: Hip Arthroplasty
Interventions: PROCEDURE: Endotracheal intubation using laryngoscope|DRUG: High remifentanil|DRUG: Low remifentanil|DRUG: High sevoflurane|DRUG: Low sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Effects of Synthetic Conjugated Estrogens, B (SCE-B) on Nocturnal Vasomotor Symptoms in Postmenopausal Women
Status: COMPLETED
Conditions: Nocturnal Vasomotor Symptoms
Interventions: DRUG: SCE-B|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Versus Water Irrigation in Upper Tract Urothelial Carcinoma
Status: RECRUITING
Conditions: Urothelial Cancer of Renal Pelvis|Urothelial Carcinoma Ureter
Interventions: PROCEDURE: sterile water irrigation|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Anxiety and Avoidance of Others in Patients Previously Treated for Head and Neck Cancer
Status: COMPLETED
Conditions: Anxiety Disorder|Head and Neck Cancer|Lung Cancer
Interventions: OTHER: Medical chart review|OTHER: Liebowitz Social Anxiety Scale and the Social Phobia and Anxiety Inventory|PROCEDURE: management of therapy complications|PROCEDURE: Structured Clinical Interview for the Diagnostic and Statistical Manual-IV SCID|OTHER: Functional Assessment of Cancer Therapy-General (FACT-G)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Management of Obstructive Colon Tumors in Istanbul
Status: UNKNOWN
Conditions: Colon Cancer|Tumor Obstruction|Emergencies|Quality of Life
Interventions: PROCEDURE: Colectomy|PROCEDURE: Stoma procedures|PROCEDURE: By-pass/laparotomy/laparoscopy/biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Influence of Growth Factors (PDGF), Applied as Autologous Thrombocyte Concentrate, on Functional Recovery
Status: COMPLETED
Conditions: Rotator Cuff Rupture|Subacromial Impingement
Interventions: BIOLOGICAL: Platelet Rich Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Photopheresis as an Interventional Therapy for the Treatment of CTCL (Cutaneous T-Cell Lymphoma, Mycosis Fungoides) Stage 1A, 1B, 2A
Status: COMPLETED
Conditions: Cutaneous T Cell Lymphoma|Mycosis Fungoides
Interventions: DRUG: Methoxsalen+ECP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-op Pain After Fistula Laser Closure or Ligation of the Intersphincteric Tract for Anal Fistula
Status: COMPLETED
Conditions: Fistula in Ano
Interventions: PROCEDURE: Laser|PROCEDURE: LIFT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Botulinum Toxin Type A Treatment of Wrinkles in Asian
Status: COMPLETED
Conditions: Botulinum Toxin, Type A
Interventions: DRUG: Botulinum toxin type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of STI-1558 in Healthy Adults and SARS-CoV-2-Positive Patients
Status: COMPLETED
Conditions: SARS-CoV-2 Infection
Interventions: DRUG: STI-1558
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Increasing the Removal of Protein-Bound Solutes During Extended Hours Hemodialysis
Status: UNKNOWN
Conditions: End Stage Renal Failure on Dialysis
Interventions: OTHER: low dialysate flow, smaller dialyzer|OTHER: high dialysate flow, larger dialyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intravenous Human Albumin In Improving Pancreaticoduodenectomy Outcomes
Status: UNKNOWN
Conditions: Pancreaticoduodenectomy|Pancreatic Fistula|Delayed Gastric Emptying|Pancreatic Cancer|Anastomotic Leak
Interventions: DRUG: Human albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Multicentre Phase I-II Study to Investigate the Combination of Bendamustine With Weekly Paclitaxel as First or Second Line Therapy in Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alpha Lipoic Acid and Chronic Lumbosacral Radicular Pain
Status: COMPLETED
Conditions: Radicular; Neuropathic, Lumbar, Lumbosacral
Interventions: PROCEDURE: pulsed radiofrequency|DRUG: pulsed radiofrequency plus alpha lipoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Treatment Continuation in Telehealth Patients Receiving an Automated Patient-Reported Outcome Tool
Status: COMPLETED
Conditions: Internet-based Intervention|Web-based Intervention|Online Intervention|Erectile Dysfunction|Telemedicine
Interventions: OTHER: An automated patient-reported outcome data collection and adverse event surveillance tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study on Endobronchial Ultrasound-guided Transbronchial Mediastinal Cryobiopsy Via a Tunnel in the Diagnosis of Mediastinal Lymphadenopathy
Status: RECRUITING
Conditions: Mediastinal Lymphadenopathy
Interventions: PROCEDURE: EBUS-TBNA|PROCEDURE: EBUS-TBMC via a tunnel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Safety and Efficacy of realSKIN® (Skin Xenotransplant) for Complete Closure of Severe Burn Wounds
Status: COMPLETED
Conditions: Deep Full-thickness Burn Injury (Disorder)
Interventions: BIOLOGICAL: realSKIN (skin xenotransplant)|BIOLOGICAL: Human Cadaver Allograft
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Iron Substitution With the Medicinal Products Ferinject or Monofer
Status: COMPLETED
Conditions: Anemia, Iron-Deficiency
Interventions: DRUG: Iron Isomaltoside 1000|DRUG: Ferric Carboxymaltose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Depression and Anhedonia in Adolescents: Linking Sleep to Reward- and Stress-Related Brain Function
Status: RECRUITING
Conditions: Depression in Adolescence
Interventions: BEHAVIORAL: Sleep extension and advance|BEHAVIORAL: Regular sleep duration and timing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Expanded Access Program in China to Provide Spesolimab to People With a Flare-up in Generalized Pustular Psoriasis Who Have no Other Treatment Options
Status: COMPLETED
Conditions: Generalized Pustular Psoriasis
Interventions: DRUG: spesolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cadonilimab With Chemoradiation for Recurrent and Oligometastatic Endometrial Carcinoma
Status: RECRUITING
Conditions: Endometrial Neoplasms|Neoplasm Recurrence, Local|Neoplasm Metastasis
Interventions: DRUG: Paclitaxel and Cisplatin|DRUG: Cadonilimab|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Iohexol for Fecal/Fluid Tagging for CT Colonography: A Study to Improve Image Quality by Preventing Colonic Bubbles
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: DRUG: Oral simethicone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy Study for the Treatment of BPH (Enlarged Prostate)
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia|Lower Urinary Tract Symptom
Interventions: DEVICE: Rezum System|PROCEDURE: Rigid Cystoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Designed Music Narratives for the Reduction of Side Effects of Chemotherapy in Children (7-12 Years) With Cancer
Status: UNKNOWN
Conditions: Cancer|Chemotherapy-induced Nausea and Vomiting|Effects of Chemotherapy
Interventions: BEHAVIORAL: Designed Music Narratives
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I, Open-label Trial to Explore the Pharmacokinetics, Safety and Tolerability of TMC278 (Rilpivirine) 25 mg Once Daily Following a 2-week Period Receiving Efavirenz, in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: TMC278|DRUG: TMC278|DRUG: Efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Randomized Clinical Trial of a Multi-Modal Palliative Care Intervention
Status: RECRUITING
Conditions: Depression, Anxiety|Metastatic Cancer
Interventions: BEHAVIORAL: Multi-Modal Palliative Care Intervention|BEHAVIORAL: Usual Care Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Effects of Cervicothoracic Junction Mobilization and Thoracic Manipulation in Subachromial Impinegment Syndrome
Status: RECRUITING
Conditions: Subacromial Impingement Syndrome
Interventions: OTHER: Cervicothoracic Junction Mobilization|OTHER: Upper Thoracic Spine Manipulation:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy Combined With Almonertinib for Stage III EGFR-Mutated Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer Stage III
Interventions: DRUG: Almonertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Topiramate to Aid in Smoking Cessation
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Topiramate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Synthetic Genistein (BONISTEIN™) in Patients Who Are Undergoing Surgery for Prostate Cancer
Status: UNKNOWN
Conditions: Prostatic Neoplasms
Interventions: DRUG: Genistein|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Musset's Surgical Technique: Evaluation of Long-term Results (LONGOMUSSET)
Status: COMPLETED
Conditions: Rectovaginal Fistula|Obstetric Complication
Interventions: PROCEDURE: surgical technique of Musset
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Study to Investigate the Effectiveness of the TOPAS System to Treat Fecal Incontinence
Status: COMPLETED
Conditions: Fecal Incontinence
Interventions: DEVICE: TOPAS Treatment for Fecal Incontinence
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT