pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Ceftazidime-Avibactam Use in Critically Ill Patients With Carbapenem-Resistant Enterobacteriaceae Infections
Status: TERMINATED
Conditions: Carbapenem-Resistant Enterobacteriaceae Infection
Interventions: DRUG: Ceftazidime-avibactam|DRUG: Colistin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Pharmacokinetics, Safety, and Tolerability of Multiple Doses of Orally Administered JNJ-53718678 in Infants Hospitalized With Respiratory Syncytial Virus (RSV) Infection
Status: TERMINATED
Conditions: Respiratory Syncytial Virus Infections|Virus Diseases
Interventions: DRUG: JNJ-53718678|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Standard Chemoimmunotherapy (FCR/BR) Versus Rituximab + Venetoclax (RVe) Versus Obinutuzumab (GA101) + Venetoclax (GVe) Versus Obinutuzumab + Ibrutinib + Venetoclax (GIVe) in Fit Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL) Without Del(17p) or TP53 Mutation
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|BIOLOGICAL: Rituximab|DRUG: Bendamustine|DRUG: Venetoclax|BIOLOGICAL: Obinutuzumab|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transgender Youth and PrEP: PK, Safety, Uptake & Adherence - Demonstration Project
Status: COMPLETED
Conditions: HIV/AIDS|Gender|Behavior and Behavior Mechanisms
Interventions: BEHAVIORAL: PrEP Demonstration Project
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Urinary Incontinence and Anxiety in Pregnancy
Status: COMPLETED
Conditions: Anxiety in Pregnancy (Disorder)|Urinary Incontinence|Quality of Life
Interventions: DIAGNOSTIC_TEST: Gynecological examination|OTHER: Pelvic Organ Prolapse Quantification (POP-Q)|OTHER: Incontinence Consultation Questionnaire-Short Form (ICIQ-SF) questionnaire|OTHER: Pregnancy-Related Anxiety Questionnaire-Revised 2 (PRAQ-R2) questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lot Consistency Study of DTaP-IPV-HB-PRP~T Vaccine Administered at 2-4-6 Months of Age in Healthy Infants
Status: COMPLETED
Conditions: Diphtheria|Tetanus|Pertussis|Hepatitis B|Poliomyelitis
Interventions: BIOLOGICAL: DTaP-IPV-HB-PRP~T vaccine|BIOLOGICAL: DTaP-IPV-HB-PRP~T vaccine|BIOLOGICAL: DTaP-IPV-HB-PRP~T vaccine|BIOLOGICAL: DTaP-HBV-IPV vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: EEG and TMS-based Biomarkers of ALS, MS and FTD
Status: UNKNOWN
Conditions: Amyotrophic Lateral Sclerosis|Frontotemporal Dementia|Multiple Sclerosis
Interventions: PROCEDURE: 128 electrode electroencephalography (EEG)|PROCEDURE: Transcranial magnetic stimulation (TMS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Outcomes Between Imageless Robotic-assisted and Conventional Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Navio™ Robotics-assisted Surgical System, LEGION Total Knee System|DEVICE: Conventional, LEGION Total Knee System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of VeSTAL Device in Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes|Metabolic Syndrome
Interventions: DEVICE: Vestal Device|DEVICE: Placebo device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aneurysmal Subarachnoid Hemorrhage: Red Blood Cell Transfusion and Outcome
Status: COMPLETED
Conditions: Subarachnoid Hemorrhage
Interventions: OTHER: Liberal Red Blood Cell Transfusion Strategy|OTHER: Restrictive Red Blood Cell Transfusion Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic, Safety, and Efficacy Effects of Oral LBH589 on Dextromethorphan in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer or Malignant Pleural Mesothelioma
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung|Mesothelioma
Interventions: DRUG: LBH589
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Effects of Eurythmy Therapy on Psychophysiological Parameters
Status: COMPLETED
Conditions: Eurythmy Therapy
Interventions: OTHER: Eurythmy Therapy Movement "R"|OTHER: Eurythmy Therapy Movement "L"|OTHER: Eurythmy Therapy Movement "B"|OTHER: Normal movements during walking or standing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized, Double-Blind, Placebo-Controlled Study of Larazotide Acetate in Subjects With Active Celiac Disease
Status: COMPLETED
Conditions: Celiac Disease
Interventions: DRUG: larazotide acetate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial Comparing Band Ligation and Cyanoacrylate Injection for Esophageal Varices
Status: COMPLETED
Conditions: Liver Disease
Interventions: DEVICE: Variceal band ligation|DRUG: cyanoacrylate injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Use of Fluconazole as Continuous Therapy Versus Periodic Therapy in HIV-Positive Patients With Recurrent Thrush
Status: COMPLETED
Conditions: Candidiasis, Oral|HIV Infections
Interventions: DRUG: Fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Initial Ventilation Strategy for Adult Immunocompromised Patients With Acute Respiratory Failure
Status: UNKNOWN
Conditions: Immunocompromised Patients|Acute Respiratory Failure
Interventions: PROCEDURE: Noninvasive mechanical ventilation|PROCEDURE: Invasive mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Guanfacine Extended-Release on Attention Deficit Hyperactivity Disorder (ADHD)-Associated Insomnia
Status: TERMINATED
Conditions: Attention-Deficit/Hyperactivity Disorder|Attention Deficit Disorder|Insomnia|Sleep Disorders
Interventions: DRUG: Guanfacine extended-release tablets|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy and Safety of Q8003 Versus Its Individual Components in Bunionectomy Patients
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Q8003|DRUG: Morphine sulfate|DRUG: Oxycodone HCl|DRUG: Q8003|DRUG: Morphine sulfate|DRUG: Oxycodone HCl 4mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ribociclib and Endocrine Therapy or Chemotherapy With or Without Bevacizumab for Metastatic Breast Cancer in First Line
Status: COMPLETED
Conditions: Breast Cancer|Hormone Receptor Positive Tumor|HER 2 Negative Breast Cancer
Interventions: COMBINATION_PRODUCT: Ribociclib and aromatase inhibitor or fulvestrant|COMBINATION_PRODUCT: Capecitabine + bevacizumab OR Paclitaxel +/- bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) With Venglustat
Status: TERMINATED
Conditions: Congenital Cystic Kidney Disease
Interventions: DRUG: Venglustat GZ402671
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dapaglifozin to Avoid Acute Kindey Injury (AKI) to Chronic Kidney Disease (CKD) Transition: DAKI-CKD Study
Status: RECRUITING
Conditions: AKI - Acute Kidney Injury|Biomarkers|Transition to CKD|CKD
Interventions: DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vaginal Progesterone Versus 17-Alpha-Hydroxyprogesterone Caproate in Placenta Previa
Status: UNKNOWN
Conditions: Placenta Previa
Interventions: DRUG: 17-OHPC|DRUG: vaginal progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Countervail Cognitive and Cerebral Decline in Mild Cognitive Impairment Patients Using Non-medical Interventions
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Music practice|BEHAVIORAL: Psychomotor therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Breastfeeding Education and Support Intervention on Timely Initiation and Exclusive Breastfeeding
Status: COMPLETED
Conditions: Breastfeeding, Exclusive|Nutrition Status
Interventions: BEHAVIORAL: Breastfeeding Education and Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Fluorescent Sentinel Lymph Node Identification in Colon Carcinoma Using Submucosal Bevacizumab-800CW.
Status: COMPLETED
Conditions: Colonic Neoplasms|Sentinel Lymph Node|Fluorescence|Colorectal Neoplasms
Interventions: PROCEDURE: Sentinel lymph node identification
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Umbilical Cord Clamping and Infant Iron Status
Status: COMPLETED
Conditions: Iron-deficiency Anemia
Interventions: PROCEDURE: Delayed umbilical cord clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Patients At Risk for Sensory Screening (HPARSS) to Enhance Sensory Deficit Screening in Childhood Cancer Survivors
Status: RECRUITING
Conditions: Childhood Cancer
Interventions: OTHER: Highlighting Patients at Risk for Sensory Screening (HPARSS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Simple Physical Exercise With Instant Messaging Support for Smoking Via "Quit to Win" Contest 2022 (QTW2022)
Status: ACTIVE_NOT_RECRUITING
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: AWARD advice|BEHAVIORAL: Referral card|BEHAVIORAL: Self-help smoking cessation booklet|BEHAVIORAL: Simple physical exercise training|BEHAVIORAL: Simple physical exercises with instant messaging support|BEHAVIORAL: SMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Investigation of New Intermittent Catheters in Healthy Volunteers
Status: COMPLETED
Conditions: Retention, Urinary
Interventions: DEVICE: SpeediCath® Standard male or female|DEVICE: New intermittent Variant 1 catheter for male or female|DEVICE: New intermittent Variant 2 catheter for male or female
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Operant Conditioning of Sensory Brain Responses to Reduce Phantom Limb Pain in People With Limb Amputation
Status: RECRUITING
Conditions: Phantom Limb Pain After Amputation|Lower Limb Amputation|Upper Limb Amputation|Phantom Pain|Chronic Pain
Interventions: BEHAVIORAL: Operant Conditioning with Peripheral Stimulation|BEHAVIORAL: Control Group with Peripheral Stimulation Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Temperature and Bicarbonate: Hemodynamic Effects During Dialysis
Status: COMPLETED
Conditions: End Stage Renal Disease on Dialysis
Interventions: OTHER: Low dialysate temperature|OTHER: High dialysate temperature|OTHER: Low dialysate bicarbonate concentration|OTHER: High dialysate bicarbonate concentration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Regional Anesthesia EMG Study
Status: RECRUITING
Conditions: Surgery
Interventions: DEVICE: BlockSynop surface electromyography device|DRUG: Clonidine|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy, Safety and Re-occurrence of Pneumothorax and Hydro-pneumothorax With Talc and Pyodine Pleurodesis
Status: UNKNOWN
Conditions: Secondary Pneumothorax
Interventions: DRUG: PYODINE AND TALC SLURRY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Potential Drug-Drug Interaction Between ZSP1273 and Oseltamivir
Status: COMPLETED
Conditions: Drug-drug Interaction
Interventions: DRUG: ZSP1273|DRUG: Oseltamivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
Status: COMPLETED
Conditions: Cancer
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Calcium carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fidaxomicin Versus Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhea (CDAD) (MK-5119-018)
Status: COMPLETED
Conditions: Clostridium Infections|Diarrhea
Interventions: DRUG: Fidaxomicin|DRUG: Vancomycin|DRUG: Matching Placebo to Fidaxomicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing the Pharmacokinetic Properties of Faster-acting Insulin Aspart (FIAsp) After Different Injection Regions and Routes of Administration in Healthy Subjects
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: Faster-acting insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Neo-adjuvant Progesterone and Vitamin D3 in Women With Large Operable Breast Cancer and Locally Advanced Breast Cancer
Status: TERMINATED
Conditions: Locally Advanced Breast Cancer and Large Operable Breast Cancer
Interventions: DRUG: Cholecalciferol|DRUG: Inj. Progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of the Analgesic Efficacy and Safety of Once Daily Tramadol HCl / Contramid® Tablets to Twice Daily Tramadol HCl (SR) for the Treatment of Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Pain
Interventions: DRUG: Tramadol HCl Contramid® Once A Day|DRUG: Tramadol HCl Twice a day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Brain Stimulation on Stepping Performance in Stroke Survivors and Healthy Adults
Status: RECRUITING
Conditions: Vascular Accident, Brain|CVA (Cerebrovascular Accident)|Gait, Hemiplegic|Spastic Lower Extremity Weakness
Interventions: DEVICE: Transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cabozantinib and Pembrolizumab for Advanced Metastatic Melanoma
Status: RECRUITING
Conditions: Advanced Metastatic Melanoma
Interventions: DRUG: Cabozantinib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrated Care After Repeated Psychiatric Hospital Stays - Evaluation of an Interdisciplinary Treatment Program
Status: ENROLLING_BY_INVITATION
Conditions: High Utilization / Heavy Use|Psychiatric Hospitalization|Rehospitalization|Intensive Care Psychiatric Disorder|Chronic Psychiatric Disorder|Health Care Utilization
Interventions: OTHER: Participation in the INTUK care offer at Klinik Zugersee
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of CD45RA+ Depleted Haploidentical Stem Cell Transplantation in Children With Relapsed or Refractory Solid Tumors and Lymphomas
Status: COMPLETED
Conditions: Ewing Sarcoma|Gastrointestinal Tumor|Germ Cell Tumor|Hepatic Tumor|Lymphoma|Wilms Tumor|Rhabdoid Tumor|Clear Cell Carcinoma|Renal Cell Carcinoma|Melanoma|Neuroblastoma|Rhabdomyosarcoma|Non-rhabdomyosarcoma
Interventions: DRUG: alemtuzumab|DRUG: fludarabine|DRUG: sirolimus|DRUG: Busulfan|DRUG: melphalan|BIOLOGICAL: stem cells|DEVICE: CliniMACS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study to Investigate the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD) and Clinical Activity of GSK525762 in Subjects With Relapsed, Refractory Hematologic Malignancies
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: GSK525762
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Genes in Sputum to Measure Drug Response in COPD
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)|Emphysema|Chronic Bronchitis
Interventions: DRUG: Salmeterol or Salmeterol/Fluticasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Diclofenac Sodium (0.1%) Gel in Patients With UV Induced Painful Sunburn
Status: COMPLETED
Conditions: Sunburn
Interventions: DRUG: Diclofenac sodium 1mg/g
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Reduce High-risk Behaviours Under Chronic Stress Via tDCS-induced Neural Plasticity
Status: UNKNOWN
Conditions: Risk-Taking|Chronic Stress
Interventions: OTHER: tDCS stimulation|OTHER: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010)
Status: RECRUITING
Conditions: Leukemia, Lymphocytic, Chronic, B-Cell|Leukemia, Chronic Lymphocytic|Small-Cell Lymphoma|Lymphoma, Small Lymphocytic|CLL|SLL
Interventions: DRUG: Nemtabrutinib|DRUG: Venetoclax|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of Bendamustine Hydrochloride in Patients With Indolent B-cell Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: bendamustine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone Intravitreal Implant for the Treatment of Persistent Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Dexamethasone intravitreal implant (0.7 mg)|DRUG: Intravitreal anti-VEGF injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the LOCI Intervention
Status: COMPLETED
Conditions: Post-traumatic Stress Disorder|Leadership
Interventions: BEHAVIORAL: LOCI|BEHAVIORAL: EMDR|BEHAVIORAL: CT-PTSD|BEHAVIORAL: TF-CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prophylactic Frequent Premature Ventricular complexeS sUPPression on Left ventriculaR Function impairmEnt in aSymptomatic patientS
Status: NOT_YET_RECRUITING
Conditions: Premature Ventricular Contractions|Ventricular Dysfunction, Left
Interventions: DRUG: Experimental group|DRUG: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Research Study Looking at How a Factor VIII Medicine Called Turoctocog Alfa Pegol (N8-GP) Works in People With Haemophilia A
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A
Interventions: DRUG: Turoctocog alfa pegol|DRUG: Turoctocog alfa pegol|DRUG: Turoctocog alfa pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of on Demand Sedation With Study Method Versus on Demand Sedation With Conventional Method for Performing Colonoscopy for Colorectal Cancer Screening and Surveillance
Status: UNKNOWN
Conditions: Colorectal Cancer Screening
Interventions: PROCEDURE: Water infusion|PROCEDURE: Air insufflation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Effect of Smoking, Abstention and Nicotine Replacement Therapy on Wound Healing
Status: COMPLETED
Conditions: Wound Healing
Interventions: DRUG: Transdermal nicotine patch|DRUG: Placebo patch|BEHAVIORAL: Smoking cessation|BEHAVIORAL: Continuous smoking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Nesiritide Infusion on Insulin Sensitivity in Healthy Obese Insulin Resistant Subjects
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: Continous IV infusion of Nesiritide|DRUG: Hyperinsulinemic euglycemic clamp|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Impact of the "Nutrition Enrichment and Healthy Living Model" ( NEHLM) on Diet Quality, Physical Activity and Dental Health Among Children From Socioeconomically Disadvantaged Families in Beer Sheva
Status: UNKNOWN
Conditions: Childhood Obesity
Interventions: BEHAVIORAL: Life-style intervention|BEHAVIORAL: Physical activity only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effects of Stair Climbing on Arterial Stiffness, Blood Pressure and Leg Strength in Stage-1 Postmenopausal Women
Status: COMPLETED
Conditions: Hypertension|Menopause
Interventions: BEHAVIORAL: Stair climbing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of the Hole in the Cardiac Septum Developed by the MitraClip Procedure on the Blood Flow Mechanics
Status: UNKNOWN
Conditions: Atrial Septal Defect
Interventions: OTHER: 2D-/3D-TTE|OTHER: 3D-TEE|OTHER: Walking Test|PROCEDURE: MitraClip procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Optimizing Access Surgery In Senior Hemodialysis Patients
Status: RECRUITING
Conditions: Vascular Access Complication|Hemodialysis Access Failure|Dialysis Access Malfunction|Arteriovenous Fistula|Arteriovenous Graft|Central Venous Catheter Related Bloodstream Infection
Interventions: PROCEDURE: Arteriovenous fistula creation|PROCEDURE: Arteriovenous graft placement|PROCEDURE: Central venous catheter placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Therapy Versus Neuromuscular Electrical Nerve Stimulation at Hemiplegic Shoulder Pain
Status: COMPLETED
Conditions: Hemiplegic Shoulder Pain
Interventions: OTHER: Laser therapy|OTHER: Neuromuscular electrical nerve stimulation|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study Evaluating the Safety of Peptide Receptor Radionuclide Therapy (PRRT) With 177Lu-DOTA0-Tyr3-Octreotate in Children With Refractory or Recurrent Neuroblastoma Expressing Somatostatin Receptors.
Status: RECRUITING
Conditions: Neuroblastoma
Interventions: DRUG: PRRT with 177Lu-DOTATATE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BreEStim for Motor Recovery in Chronic Stroke With Moderate Impairment (Pilot).
Status: NOT_YET_RECRUITING
Conditions: Motor Recovery
Interventions: DEVICE: BreEStim|DEVICE: EStim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prospective Controlled Randomized Study of PAE vs TURP for BPH Treatment.
Status: WITHDRAWN
Conditions: Benign Prostatic Hyperplasia
Interventions: PROCEDURE: PAE|DEVICE: Gelatin microspheres|PROCEDURE: TURP|DEVICE: Bipolar electrosurgery generator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect on Parameters of Systemic Inflammation and Disease Outcomes and Safety of RPH-104 in Subjects With Acute ST-elevation Myocardial Infarction
Status: COMPLETED
Conditions: Acute ST Segment Elevation Myocardial Infarction
Interventions: BIOLOGICAL: RPH-104 80 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Optimal Treatment With Bevacizumab in Patients With Platinum-sensitive Recurrent Ovarian Cancer
Status: COMPLETED
Conditions: Recurrent Platinum-sensitive Ovarian Cancer
Interventions: DRUG: Carboplatin|DRUG: PLD|BIOLOGICAL: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Of Lersivirine Single 750 Mg Tablet Versus 3 X 250 Mg Tablets
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Lersivirine|DRUG: Lersivirine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Pecs Blocks on Postmastectomy Pain Syndrome
Status: COMPLETED
Conditions: Pain Syndrome|Pain, Postoperative|Chronic Pain|Breast Cancer|Breast Soft Tissue Neoplasm|Breast Neoplasms|Breast Cancer Female|Breast Pain|Anesthesia
Interventions: OTHER: Pecs block|OTHER: no Pecs block
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Differing Levels of Support for Family Mealtimes on Obesity Prevention Among Head Start Preschools
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Mealtime Supports|BEHAVIORAL: Usual Exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Toric Intraocular Lenses for Cataract Patients in the NHS
Status: UNKNOWN
Conditions: Cataract|Astigmatism|Cornea
Interventions: PROCEDURE: 'Off the shelf' toric lens|PROCEDURE: Tailored Toric lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Refnot on Immunity in Cancer Patients
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: Tumor necrosis factor-thymosin alfa 1 recombinant (TNF-T)|DRUG: Tumor necrosis factor-thymosin alfa 1 recombinant (TNF-T) and chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AZARGA Transition Study in Taiwan for Patients With Uncontrolled Intraocular Pressure
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Brinzolamide 1% and timolol 0.5% fixed combination eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rest Easy: Is Bed Rest Really Necessary After Surgical Repair of an Ankle Fracture?
Status: COMPLETED
Conditions: Ankle Injuries|Fracture
Interventions: PROCEDURE: Early mobilization|PROCEDURE: Standard mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of Jaktinib for the Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease.
Status: NOT_YET_RECRUITING
Conditions: Acute Graft-Versus-Host Disease
Interventions: DRUG: Jaktinib Hydrochloride Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Insomnia Therapy for Individuals With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia|Sleep Initiation and Maintenance Disorders
Interventions: BEHAVIORAL: Cognitive behavioral therapy for insomnia|BEHAVIORAL: Pseudo-desensitization procedure|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Basal-bolus and Premixed Insulin Regimens in Hospitalized Patients With Type 2 Diabetes (PININ Study)
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Mixtard 30:70 Novonordisk® twice daily|DRUG: Lantus® once daily and Apidra® before meals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of a Soluble Fiber Consumption on Immunity Response
Status: COMPLETED
Conditions: Immune Response
Interventions: OTHER: Soluble fiber|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Use of a 3D Printer to Make Custom Sleep Masks for Positive Airway Pressure Treatment
Status: COMPLETED
Conditions: Sleep Apnea|Pediatric Sleep Apnea
Interventions: DEVICE: 3D printed NIV mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of S-8184 in Second Line Treatment of Stage III or IV Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: S-8184 Paclitaxel Injectable Emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study for the Quantification in Ecological Conditions of Sensorimotor and Dysexecutive Disorders in Cerebral Palsy Patients
Status: RECRUITING
Conditions: Dysexecutive Syndrome
Interventions: BEHAVIORAL: Chocolate cake|BEHAVIORAL: Lego model|DEVICE: Measurement of sensorimotor abilities|OTHER: Measurement of facial expression of emotions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Paracor Ventricular Support System (PVSS) for Patients With Heart Failure
Status: TERMINATED
Conditions: Heart Failure, Congestive
Interventions: DEVICE: Placement of the PVSS Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Electrical Nerve Stimulation (TENS) for Lower Urinary Tract Disorders in Parkinson's Syndrome
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DEVICE: TENS|DEVICE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tele-Exercise for Male Elite Fencers
Status: COMPLETED
Conditions: Sports Physical Therapy|Athletic Performance
Interventions: OTHER: Tele-exercise program|OTHER: Conventional Fencing Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: AUgmented REality for the Visually Impaired - Part 1
Status: COMPLETED
Conditions: Retinitis Pigmentosa|Glaucoma
Interventions: PROCEDURE: Find visual comfort threshold related to light intensity|PROCEDURE: Find the size of the visual field|PROCEDURE: Effectiveness of brightness control|PROCEDURE: Performance of color correction|DEVICE: Vuzix Wrap 1200DX virtural reality glasses
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prospective Study on the Vaccine Response to Meningococcal B Vaccine After Allogeneic Stem Cell Transplantation
Status: COMPLETED
Conditions: Hematopoietic Stem Cell Transplant|Meningococcal Vaccine
Interventions: BIOLOGICAL: B vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Beer, Red Wine and Fruit Juice on Blood Vessel Function in Persons With Cardiovascular Disease
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: BEHAVIORAL: Moderate daily consumption of Red wine|BEHAVIORAL: Moderate daily consumption of beer|BEHAVIORAL: Moderate consumption of fruit juice rich in polyphenolics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Management and Optimization of Nutrition, Antenatal, Reproductive, Child Health & HIV Care
Status: COMPLETED
Conditions: Pregnancy|HIV
Interventions: OTHER: Quality Improvement|OTHER: Baseline data collection (active comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Investigate Efficacy and Safety of KBL697 in Patients With Moderate Plaque Type Psoriasis
Status: UNKNOWN
Conditions: Psoriatic Plaque
Interventions: DRUG: KBL697|DRUG: KBL697
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Different Wound Dressings in Split-skin Grafted Third Degree Burns
Status: RECRUITING
Conditions: Split-skin Grafted Third-degree Burn Wound
Interventions: DEVICE: Silver Nylon dressing|DEVICE: Manuka-Honey|DEVICE: Povidone-Iod (PVP-Iod)|DEVICE: Hydrogel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Manipulating E-Cigarette Nicotine to Promote Public Health
Status: RECRUITING
Conditions: Tobacco-Related Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Carbon Monoxide Measurement|OTHER: Vaping session|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Continuous Hyperosomolar Therapy for Traumatic Brain-injured Patients
Status: COMPLETED
Conditions: Moderate to Severe Traumatic Brain Injury
Interventions: DRUG: NaCl20% (Continuous hyperosmolar therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Stop&Go: an Intervention Program to Promote Healthy and Active Lifestyles Among Patients With Substance Use Disorders
Status: COMPLETED
Conditions: Substance Use Disorder|Motivation
Interventions: BEHAVIORAL: Stop&Go Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Dose Escalation Study to Assess the Safety and Efficacy of Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis or Sarcoidosis
Status: COMPLETED
Conditions: Pulmonary Hypertension|Pulmonary Fibrosis|Sarcoidosis, Pulmonary
Interventions: COMBINATION_PRODUCT: iNO
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VR-PAT During Home Burn Dressings - Multisite
Status: ENROLLING_BY_INVITATION
Conditions: Burns|Acute Pain|Procedural Pain|Injuries|Pediatric ALL
Interventions: OTHER: VR-PAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of ASTX660 (Tolinapant) to the Usual Chemotherapy Treatment (Paclitaxel With or Without Bevacizumab) in Patients With Recurrent Ovarian Cancer
Status: NOT_YET_RECRUITING
Conditions: Platinum-Refractory Fallopian Tube Carcinoma|Platinum-Refractory Ovarian Carcinoma|Platinum-Refractory Primary Peritoneal Carcinoma|Recurrent Fallopian Tube Adenocarcinoma|Recurrent Fallopian Tube Carcinosarcoma|Recurrent Fallopian Tube Clear Cell Adenocarcinoma|Recurrent Fallopian Tube High Grade Serous Adenocarcinoma|Recurrent Fallopian Tube Undifferentiated Carcinoma|Recurrent High Grade Endometrioid Adenocarcinoma|Recurrent Ovarian Adenocarcinoma|Recurrent Ovarian Carcinosarcoma|Recurrent Ovarian Clear Cell Adenocarcinoma|Recurrent Ovarian High Grade Serous Adenocarcinoma|Recurrent Ovarian Seromucinous Carcinoma|Recurrent Ovarian Undifferentiated Carcinoma|Recurrent Platinum-Resistant Fallopian Tube Carcinoma|Recurrent Platinum-Resistant Ovarian Carcinoma|Recurrent Platinum-Resistant Primary Peritoneal Carcinoma|Recurrent Primary Peritoneal Adenocarcinoma|Recurrent Primary Peritoneal Carcinosarcoma|Recurrent Primary Peritoneal Clear Cell Adenocarcinoma|Recurrent Primary Peritoneal High Grade Serous Adenocarcinoma|Recurrent Primary Peritoneal Undifferentiated Carcinoma
Interventions: BIOLOGICAL: Bevacizumab|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Paclitaxel|DRUG: Tolinapant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effectiveness and Safety of the ID-Cap System for Medication Monitoring and Adherence
Status: COMPLETED
Conditions: Medication Adherence
Interventions: DEVICE: MEMS Cap|DEVICE: ID-Cap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Does Melatonin Restore Sleep Architecture in Autistic Children
Status: COMPLETED
Conditions: Sleep Disorders
Interventions: DRUG: melatonin|DRUG: Melatonin|DRUG: Melatonin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Follow up Protocol to the Phase I/II Study of OPN-305 in Second-line or Third-line Lower Lower Risk Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: OPN-305
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Knee
Status: RECRUITING
Conditions: Osteoarthritis
Interventions: BIOLOGICAL: [StroMed + platelet rich plasma (PRP)]|BIOLOGICAL: [PRP] platelet rich plasma|BIOLOGICAL: [PRP] platelet rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Safety Study of AT-100 (rhSP-D) in Preterm Neonates at High Risk for Bronchopulmonary Dysplasia (BPD)
Status: COMPLETED
Conditions: Bronchopulmonary Dysplasia
Interventions: BIOLOGICAL: AT-100|PROCEDURE: Air-sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of GlaxoSmithKline's Herpes Zoster Subunit Vaccine (HZ/su) When Given on a Two-dose Schedule to Adults at Least 50 Years of Age (YOA) Who Had Prior Episode of Shingles
Status: ACTIVE_NOT_RECRUITING
Conditions: Herpes Zoster
Interventions: BIOLOGICAL: Herpes Zoster subunit (HZ/su) vaccine (GSK1437173A)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Randomized Trial to Evaluate the Efficacy of Two Different Toothbrushes on Plaque Control
Status: UNKNOWN
Conditions: Plaque|Gingivitis
Interventions: DEVICE: Group using manual toothbrush Curaprox 5460 Ultra Soft|DEVICE: Group using sonic toothbrush Edel White
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Randomized Field Trial of Smartphone-based Feedback to Encourage Safe Driving
Status: RECRUITING
Conditions: Distracted Driving|Injury Prevention|Behavioral Economics
Interventions: BEHAVIORAL: Driving Tips|BEHAVIORAL: Standard Feedback|BEHAVIORAL: Assigned Focus Area Feedback|BEHAVIORAL: Study Dashboard (Standard)|BEHAVIORAL: Study Dashboard (focused)|BEHAVIORAL: UBI-like Behavioral Incentive|BEHAVIORAL: Sef-Chosen Focus Area Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Tobacco Heating System (THS) on Closed Tibia Fracture Healing
Status: RECRUITING
Conditions: Smoking|Tibia Fracture
Interventions: DEVICE: Tobacco Heating System (THS)|OTHER: Smoking abstinence
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Adaptation of Individual Dialectical Behavior Therapy Intervention for Transdiagnostic Treatment of Emotional Disorders
Status: RECRUITING
Conditions: Anxiety Disorder|Depressive Disorder
Interventions: BEHAVIORAL: Dialectical behavior therapy (DBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tools for Improving Colorectal Cancer Screening Rates: Multimedia Versus Print
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BEHAVIORAL: Multimedia Education|BEHAVIORAL: Print Media|BEHAVIORAL: Usual and customary waiting room process
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: GERD and Anti-Reflux Therapy Between Able-bodied and SCI Individuals
Status: UNKNOWN
Conditions: Gastro Esophageal Reflux Disorder
Interventions: DRUG: Omeprazole|DEVICE: 24 Hour pH Monitor|PROCEDURE: Pulmonary Function Examination|PROCEDURE: Exhaled Nitric Oxide|PROCEDURE: Exhaled Breath Concentrate (EBC)|PROCEDURE: Bernstein's Acid Clearance Test|PROCEDURE: Esophageal Motility
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotic Limosilactobacillus Reuteri (L. Reuteri) on Crying and Fussing Time in Infants With Colic
Status: NOT_YET_RECRUITING
Conditions: Infantile Colic
Interventions: DIETARY_SUPPLEMENT: L. reuteri|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CPI-006 Alone and in Combination With Ciforadenant and With Pembrolizumab for Patients With Advanced Cancers
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer|Renal Cell Cancer|Colorectal Cancer|Triple Negative Breast Cancer|Cervical Cancer|Ovarian Cancer|Pancreatic Cancer|Endometrial Cancer|Sarcoma|Squamous Cell Carcinoma of the Head and Neck|Bladder Cancer|Metastatic Castration Resistant Prostate Cancer|Non-hodgkin Lymphoma
Interventions: DRUG: CPI-006|DRUG: CPI-006 + ciforadenant|DRUG: CPI-006 + pembrolizumab|DRUG: CPI-006|DRUG: CPI-006 + ciforadenant|DRUG: CPI-006 + pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT