pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Healthy Hearts: Leveraging the Diabetes Prevention Program to Decrease Health Disparities in Women of Reproductive Age
Status: WITHDRAWN
Conditions: Prediabetic State|Gestational Weight Gain|Hypertension|Overweight or Obesity
Interventions: BEHAVIORAL: Diabetes Prevention Program Plus (DPP+)|BEHAVIORAL: Diabetes Prevention Program (DPP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The DES BTK Vascular Stent System vs PTA in Subjects With Critical Limb Ischemia
Status: COMPLETED
Conditions: Critical Limb Ischemia
Interventions: COMBINATION_PRODUCT: Drug Eluting Stent - Below the Knee|DEVICE: Standard PTA Control Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Investigating Cyanoacrylate Glue to Prevent Surgical Site Infection Following Breast Surgery
Status: UNKNOWN
Conditions: Surgical Wound Infection
Interventions: OTHER: 2-Octyl Cyanoacrylate Glue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability & Pharmacokinetics of LEVI-04 in Healthy Volunteers and Patients With Osteoarthritis Knee Pain
Status: COMPLETED
Conditions: Healthy Volunteers|Osteoarthritis
Interventions: DRUG: LEVI-04|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Treatment of Gastroesophageal Reflux Disease in 12-16 Year Old Patients With Rabeprazole
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: rabeprazole sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Screening for Pancreatic Ductal Adenocarcinoma in High-Risk Individuals
Status: RECRUITING
Conditions: Pancreatic Cancer|Pancreatic Ductal Adenocarcinoma|PDAC|PDAC - Pancreatic Ductal Adenocarcinoma|Pancreatic Neoplasm
Interventions: OTHER: Screening Blood Tests|DIAGNOSTIC_TEST: Endoscopic Ultrasound|COMBINATION_PRODUCT: Magnetic Resonance Imaging|COMBINATION_PRODUCT: Magnetic Resonance Cholangiopancreatography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study to Assess the Safety, Tolerability and Immune Response Following Vaccination With Immunose™ FLU
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: 15 µg HA/strain and 1% Endocine™|BIOLOGICAL: 15 µg HA/strain and 2% Endocine™|BIOLOGICAL: 15 µg HA/strain|BIOLOGICAL: intramuscular comparator|BIOLOGICAL: intranasal comparator|BIOLOGICAL: Placebo, Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Calcitonin Gene-related Peptide Levels in Chronic Migraine
Status: COMPLETED
Conditions: Chronic Migraine
Interventions: DRUG: OnabotulinumtoxinA|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pain Control With Fentanyl Patch in Patients Undergoing Mastectomy and TRAM or DIEP Flap Reconstruction
Status: COMPLETED
Conditions: Postoperative Pain After Breast Reconstruction With Abdominal Flap
Interventions: DRUG: Fentanyl|DRUG: Inactive patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Benefit of Using Fibrin Glue in Septorhinoplasty
Status: TERMINATED
Conditions: Recovery Time|Bruising
Interventions: DRUG: Fibrinogen|PROCEDURE: Septorhinoplasty|PROCEDURE: Taping after septorhinoplasty.|PROCEDURE: Cast applied to the nose after nasal surgery|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate The Efficacy And Safety Of Sunpharma1505 Compared With Reference1505 In Subjects With Active Rheumatoid Arthritis
Status: TERMINATED
Conditions: Active Rheumatoid Arthritis
Interventions: DRUG: Treatment I|DRUG: Treatment II|DRUG: Treatment III
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Obinutuzumab|DRUG: Placebo|DRUG: Acetaminophen/Paracetamol|DRUG: Diphenhydramine hydrochloride|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of EXPAREL® on Postsurgical Pain, and the Use of Narcotics
Status: SUSPENDED
Conditions: Rotator Cuff Tear
Interventions: DRUG: EXPAREL 1.3 % in 20 ML Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Protective Ventilation in Abdominal Surgery (IMPROVE Study)
Status: COMPLETED
Conditions: Protective Lung Ventilation Using:|Low Tidal Volume (6-8 mL/kg Predicted Body Weight)|PEEP of 6-8 cmH2O|Intraoperative RMs
Interventions: OTHER: Abdominal surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of Escalating Doses of Idarubicin Orally Given With Oral Cyclophosphamide, Etoposide, Prednisolone and Intravenous Rituximab in Elderly Patient With Disseminated High Grade Non Hodgkin Lymphoma
Status: COMPLETED
Conditions: High Grade Lymphomas CD20 Positive
Interventions: DRUG: idarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Placebo|DRUG: Dexpramipexole 50 mg/day|DRUG: Dexpramipexole 150 mg/day|DRUG: Dexpramipexole 300 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Add-On Study of MSI-195 (S-Adenosyl-L-Methionine, SAMe) for Patients With Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Major Depressive Disorder (MDD)
Interventions: DRUG: MSI-195|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Myo-inositol Therapy on the Dynamics of Embryo Development in Patients Suffering From PCOS Undergoing ICSI Treatment
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Infertility
Interventions: DIETARY_SUPPLEMENT: Inofolic: myo-inositol and folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Profile of RAD001 Daily in Chinese Patients With Advanced Pulmonary Neuroendocrine Tumor
Status: UNKNOWN
Conditions: Neuroendocrine Tumors|Carcinoid Tumor
Interventions: DRUG: RAD001 (everolimus, Afinitor®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pars Plana Vitrectomy With 25-gauge 20000 Cpm, Bevel-tip Cutter
Status: UNKNOWN
Conditions: Vitrectomy|Retinal Detachment|Vitreous Hemorrhage|Macular Holes|Epiretinal Membrane|Dislocated Intraocular Lens Into Vitreous|Retained Lens Fragments
Interventions: DEVICE: 25-gauge, bevel-tip, 20000 cut per minute pars plana vitrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Fuel - Morning Nutrition and Cognitive Function
Status: ACTIVE_NOT_RECRUITING
Conditions: Obese|Healthy
Interventions: DIETARY_SUPPLEMENT: High protein/low carbohydrate|DIETARY_SUPPLEMENT: High carbohydrate/low protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate a Probiotic in Healthy Subjects With a History of Abdominal Discomfort and Bloating
Status: COMPLETED
Conditions: Abdominal Discomfort|Bloating
Interventions: DIETARY_SUPPLEMENT: B. infantis 35624|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety Study of Alogliptin in Participants With Type 2 Diabetes in Japan
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Alogliptin|DRUG: Alogliptin|DRUG: Alogliptin|DRUG: Alogliptin|DRUG: Voglibose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Pharmacokinetic Study Between HLX02 and Herceptin®(US-licensed and EU-approved) in Healthy Chinese Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HLX02|DRUG: EU-sourced Trastuzumab (Herceptin®)|DRUG: US-licensed Trastuzumab (Herceptin®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Myofascial Release of Physiological Chains and Muscle Stretching in Patients With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: OTHER: Myofascial release|OTHER: Muscle stretching|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability,Immunogenicity, and Pharmacokinetics of MEDI-528 in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: MEDI-528 0.3 mg/kg|BIOLOGICAL: MEDI-528 1 mg/kg|BIOLOGICAL: MEDI-528 3 mg/kg|BIOLOGICAL: MEDI-528 9 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuroimaging Approaches to Deconstructing Acupuncture for Chronic Pain
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: Needle acupuncture (Traditional Acupuncture)|DEVICE: Laser acupuncture (Non-traditional Acupuncture)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Romosozumab (AMG 785) in Tibial Diaphyseal Fractures Status Post Intramedullary Nailing
Status: COMPLETED
Conditions: Fracture Healing
Interventions: BIOLOGICAL: Romosozumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SARS-CoV-2/COVID-19 Study of Next Generation Non-Invasive Passive Detection Technologies
Status: RECRUITING
Conditions: COVID-19|SARS-CoV-2 Virus|COVID-19 Pneumonia|COVID-19 Respiratory Infection|COVID-19 Acute Respiratory Distress Syndrome|Corona Virus Infection|Influenza|RSV Infection
Interventions: DEVICE: imPulse™ Systems (Una and TOR) infrasound-to-ultrasound e-stethoscope
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Functional Electrical Stimulation Assisted Cycling in Patients With Hemiparesis After Stroke
Status: RECRUITING
Conditions: Hemiparesis;Poststroke/CVA
Interventions: DEVICE: FES-cycling|DEVICE: SHAM-cycling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: First-line FOLFOXIRI In Combination With Bevacizumab For Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer Metastatic
Interventions: DRUG: Bevacizumab|DRUG: Irinotecan|DRUG: Oxaliplatin|DRUG: 5-fluorouracil/leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mel vs BUCY+VP-16 Conditioning Regimen for MM Undergoing Auto-HSCT
Status: UNKNOWN
Conditions: Autologous Hematopoietic Stem Cell Transplantation|Conditioning|Multiple Myeloma
Interventions: DRUG: Busulfan (BU)|DRUG: Cyclophosphamide (CY)|DRUG: Etoposide (VP-16)|DRUG: Melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study Of The Farnesyltransferase Inhibitor ZANESTRA (R115777, NSC #702818, IND #58,359) In Complete Remission Following Induction And/Or Consolidation Chemotherapy In Adults With Poor-Risk Acute Myelogenous Leukemia (AML) And High-Risk Myelodysplasia (MDS)
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|de Novo Myelodysplastic Syndromes|Secondary Myelodysplastic Syndromes
Interventions: DRUG: tipifarnib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Rifaximin Versus Norfloxacin in the Secondary Prophylaxis of Spontaneous Bacterial Peritonitis
Status: UNKNOWN
Conditions: Spontaneous Bacterial Peritonitis|Ascites|Liver Cirrhosis
Interventions: DRUG: Rifaximin|DRUG: Norfloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Synthetic Thyrotropin Releasing Hormone (TRH) as a Treatment for Cancer-related Fatigue
Status: TERMINATED
Conditions: Cancer-related Fatigue
Interventions: DRUG: Thyrotropin releasing hormone (TRH)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Two Resurfacing Prostheses in the Treatment of Osteoarthritis of the Shoulder
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: PROCEDURE: Copeland or Global CAP resurfacing prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Trial to Investigate the Safety and Tolerability of PF-06412562
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06412562|DRUG: PF-06412562
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cefalium® Compared to Tylenol® in the Treatment of Migraine Attacks
Status: SUSPENDED
Conditions: Migraine
Interventions: DRUG: Acetaminophen+Caffeine+Dihydroergotamine+Metoclopramide.|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Rehabilitation of Older Patients With Schizophrenia
Status: COMPLETED
Conditions: Psychotic Disorders|Schizoaffective Disorder|Schizophrenia
Interventions: BEHAVIORAL: Cognitive Behavioral Social Skills Training (CBSST)|BEHAVIORAL: Goal Focused Supportive Contact (GFSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Compare Radiation Fibrosis With Five Versus Three Fractions
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Neoplasm of Breast Stage I
Interventions: RADIATION: Arm 1 600 cGY x 5 fractions|RADIATION: Arm 2 800 cGY x 3 fractions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Seroquel (Quetiapine) Study for Treatment Resistant Functional Bowel Disorder
Status: COMPLETED
Conditions: Functional Bowel Disorders
Interventions: DRUG: Quetiapine (50 mg/day-100mg/day)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Appropriate Compatibility of Propofol and Sevoflurane for Orthopaedic Surgery of Patients With MCI
Status: UNKNOWN
Conditions: Cognitive Impairment, Mild
Interventions: DRUG: Propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: The Safety and Tolerability of PD-L1 Monoclonal Antibody Plus Lenalidomide in The Treatment of Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Neoplasms
Interventions: DRUG: PD-L1 Monoclonal Antibody Combined With Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Remimazolam on the Incidence of Severe Hypoxia During Sedated Hysteroscopy for Assisted Reproduction in Overweight or Obese Patients
Status: RECRUITING
Conditions: Hypoxia|Hysteroscopy|Overweight or Obesity
Interventions: DRUG: remimazolam|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Radiation Therapy Plus Chemotherapy Before Surgery With or Without Chemotherapy After Surgery in Treating Patients With Rectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: chemotherapy|DRUG: fluorouracil|DRUG: leucovorin calcium|PROCEDURE: conventional surgery|RADIATION: low-LET cobalt-60 gamma ray therapy|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: To Explore the Anti-oxidative Effects and Inflammation Effects of Soy Protein to Renal Function of End Stage Diabetes Nephropathy Patients
Status: COMPLETED
Conditions: Diabetic Nephropathies
Interventions: DIETARY_SUPPLEMENT: soy protein drink|DIETARY_SUPPLEMENT: casein protein drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Magnesium and Bladder Spasms Following Ambulatory Urologic Procedures
Status: RECRUITING
Conditions: Bladder Spasms
Interventions: DRUG: Magnesium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Chronic Pain Master Protocol (CPMP): A Study of LY3016859 in Participants With Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low-back Pain
Interventions: DRUG: LY3016859|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Do Core Stability Exercise Classes Help Children With Cerebral Palsy Improve Their Balance
Status: UNKNOWN
Conditions: Cerebral Palsy
Interventions: OTHER: Physiotherapy Core Stability Group Programme|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Of Fesoterodine In Pediatric Overactive Bladder Patients Aged 8-17 Years
Status: COMPLETED
Conditions: Overactive Bladder|Neurogenic Detrusor Overactivity
Interventions: DRUG: Fesoterodine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Immediate-Release Viloxazine in Adults With ADHD
Status: COMPLETED
Conditions: Attention-Deficit/Hyperactivity Disorder (ADHD)
Interventions: DRUG: IR Viloxazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia
Status: RECRUITING
Conditions: COVID-19 Pneumonia|Sepsis|SARS-CoV-2 Acute Respiratory Disease|Pneumonia|Multiorgan Failure
Interventions: DIAGNOSTIC_TEST: Chest X-ray
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intervening With and Improving Care for Patients at Risk for Frequent Hospital Admissions
Status: COMPLETED
Conditions: Hospitalization|Patient Readmission
Interventions: OTHER: Provision of extra (care coordination and management) services
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Probiotics-prebiotic Fiber Therapy in Parkinson's Disease Patients With Constipation
Status: COMPLETED
Conditions: Parkinson Disease|Constipation
Interventions: DIETARY_SUPPLEMENT: Probiotics with prebiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SALIRI Based Regimen as First-line Treatment for Advanced Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Advanced Metastatic Colorectal Cancer
Interventions: DRUG: Raltitrexed|DRUG: Irinotecan|DRUG: Bevacizumab|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Plant-based Ingredient
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Plant-based ingredient added to starchy meal|DIETARY_SUPPLEMENT: Plant-based ingredient added to liquid|DIETARY_SUPPLEMENT: No Plant-based ingredient
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of a Glucagon Like Peptide 1 (GLP1) Booster in Healthy Humans
Status: ACTIVE_NOT_RECRUITING
Conditions: Blood Sugar; High|Overweight and Obesity|Fat Burn|Obesity
Interventions: DIETARY_SUPPLEMENT: GLP1 Booster (GB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Myopia Control by Breath-O Correct Orthokeratology Lenses
Status: COMPLETED
Conditions: Myopia|Orthokeratology
Interventions: DEVICE: Breath-O orthokeratology lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Dosimetry of [68Ga]-NOTA-hGZP (CSB-111) PET Imaging in Healthy Human Volunteers.
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: CSB-111
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Efficacy and Safety of Belviq XR® in Conjunction With Lifestyle Modification for Weight Loss in Obese Adolescents, Age 12 to 17 Years
Status: TERMINATED
Conditions: Obesity
Interventions: DRUG: lorcaserin hydrochloride XR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Target Fortified Human Milk on the Growth Quality of Very Preterm Infants (TargetFort)
Status: UNKNOWN
Conditions: Growth|Body Composition|Prematurity|Breast Milk Collection|Nutrient Deficiency|Feeding Patterns|Adiposity
Interventions: DIETARY_SUPPLEMENT: standard HM fortification|DIETARY_SUPPLEMENT: target HM fortification
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Long-Term Side Effects of Ruxolitinib in Treating Patients With Myelofibrosis
Status: COMPLETED
Conditions: Myelofibrosis
Interventions: OTHER: Long-term Follow-up|OTHER: Quality-of-Life Assessment|DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparision Between Paracetamol and Ibuprofen in Closure of Patent Ductus Arteriosus
Status: NOT_YET_RECRUITING
Conditions: Patent Ductus Arteriosus
Interventions: DRUG: Paracetamol|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Electrical Acupoint Stimulation(TEAS) for Hepatic and Renal Dysfunction After Pneumoperitoneum
Status: COMPLETED
Conditions: Hepatic Dysfunction Transient|Renal Function Disorder
Interventions: OTHER: TEAS pretreatment|OTHER: TEAS treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Verifying the Effectiveness of the NUsurface® System
Status: COMPLETED
Conditions: Meniscectomy|Osteoarthritis
Interventions: DEVICE: NUsurface® Meniscus Implant|DRUG: NSAID's and Non-surgical Treatment Options|DRUG: Intra-Articular Injections with Corticosteroids|DRUG: Intra-Articular Injections with Hyaluronic Acid (HA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Hospital-to-Home Care Transitions for High-risk Younger Adult Patients
Status: COMPLETED
Conditions: Patient Discharge
Interventions: BEHAVIORAL: Transition Coach (TC)|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Electrical Neuromodulation for Focal Epilepsy
Status: NOT_YET_RECRUITING
Conditions: Epilepsy
Interventions: DEVICE: Soterix MXN-5 HD-tES Model 5005A. Medtronic Percept DBS platform.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Autologous Bone Marrow Stem Cell Transplantation in Patients With Subacute Spinal Cord Injury
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injuries
Interventions: GENETIC: Mesenchymal stem cell transplantation|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of Interleucin-2 Combined With PD-1 Monoclonal Antibody and CAPOX in Preoperative Neoadjuvant Therapy for Locally Advanced Rectal Cancer - a Single-center, Single-arm, Open-label Clinical Trail
Status: RECRUITING
Conditions: Locally Advanced Rectal Adenocarcinoma
Interventions: DRUG: Sintilimab with Interleukin-2+CAPOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Peer-to-Peer Community Support to Promote Aging in Place
Status: COMPLETED
Conditions: Wellness Programs|Hospitalization|Emergency Room
Interventions: BEHAVIORAL: Peer-to-Peer Support|BEHAVIORAL: Standard Community Services
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Safety, Reactogenicity, and Immunogenicity of mRNA-1283 and mRNA-1273 Vaccines in Healthy Adults Between 18 Years and 55 Years of Age to Prevent COVID-19
Status: COMPLETED
Conditions: SARS-CoV-2
Interventions: BIOLOGICAL: mRNA-1283|BIOLOGICAL: mRNA-1273|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Compression Anastomosis For Low Anterior Resection in Previously Radiated Patients Using the CAR™ 27
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DEVICE: CAR™ 27
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study About Sleep Quality and Its Impact on Daily Life of Nursing-home Residents
Status: COMPLETED
Conditions: Sleep|Cognitive Impairment|Quality of Life|Age Problem|Aging
Interventions: DEVICE: Xiaomi MiBand2|OTHER: Socio-demographic questionnaire|OTHER: EuroQol-5D-5L|OTHER: Mini mental State Examination|OTHER: Tinetti Scale|OTHER: Barthel Index|OTHER: Pittsburgh Sleep Quality Assessment (PSQI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Rheosorbilact® Solution for Infusion, in a Complex Therapy of Burns
Status: UNKNOWN
Conditions: Burns|Intoxication
Interventions: DRUG: Rheosorbilact®|DRUG: Ringer lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Surgical Rectus Sheath Block for Postoperative Analgesia After Elective Cesarean Delivery
Status: NOT_YET_RECRUITING
Conditions: Post Operative Pain
Interventions: PROCEDURE: surgical rectus sheath block|PROCEDURE: subdermal local anaesthetic infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Precision Spectra™ Programming Features and Lead Options on Patient Outcomes
Status: TERMINATED
Conditions: Chronic Pain
Interventions: DEVICE: Conventional single source programming|DEVICE: Precision Spectra SCS System advanced programming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen in Norway: A Prospective Cohort Study
Status: UNKNOWN
Conditions: Amyotrophic Lateral Sclerosis|Cognitive Impairment
Interventions: DIAGNOSTIC_TEST: ECAS-N|DIAGNOSTIC_TEST: MoCA|DIAGNOSTIC_TEST: CDR|OTHER: Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Prevention for Postoperative Nausea and Vomiting After Intrathecal Morphine in Cesarean Section
Status: UNKNOWN
Conditions: Pregnancy|PONV
Interventions: DRUG: dexamethasone|DRUG: dexamethasone 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hydroxychloroquine Treatment for Severe COVID-19 Pulmonary Infection (HYDRA Trial)
Status: COMPLETED
Conditions: COVID-19|Severe Acute Respiratory Syndrome
Interventions: DRUG: Hydroxychloroquine|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Folfox4 Chemotherapy Regimen to Prevent Early Postoperative Recurrence for HCC-PVTT Patients
Status: UNKNOWN
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: folfox4 chemotherapy regimen|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase I Trial Of The Humanized Anti-GD2 Antibody In Children And Adolescents With Neuroblastoma, Osteosarcoma, Ewing Sarcoma and Melanoma
Status: COMPLETED
Conditions: Neuroblastoma|Melanoma|Osteosarcoma|Ewing Sarcoma
Interventions: BIOLOGICAL: Anti-GD2 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromodulation and Neuroimaging in Older Children With Mild Traumatic Brain Injury
Status: RECRUITING
Conditions: Brain Concussion|Mild Traumatic Brain Injury|Motor Disorders|Cognitive Impairment
Interventions: DEVICE: tDCS in Youth with mild traumatic brain injury
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Prostate Specific Antigen Levels During Synergo Therapy-Intravesical Chemotherapy Instillations Combined With Hyperthermia
Status: UNKNOWN
Conditions: Bladder Cancer
Interventions: DEVICE: SYNERGO|DEVICE: SYNERGO-intravesical chemotherapy instillation combined with hyperthermia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Internet-based Self-management Program for Adolescents With Arthritis
Status: COMPLETED
Conditions: Arthritis, Juvenile Idiopathic
Interventions: BEHAVIORAL: Taking Charge: Managing JIA Online|BEHAVIORAL: Standard Medical Care and JIA Resource Center
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Unrelated Donor Transplant Versus Immune Therapy in Pediatric Severe Aplastic Anemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Severe Aplastic Anemia
Interventions: DRUG: cyclosporine|PROCEDURE: Matched Unrelated Donor Hematopoietic Stem Cell Transplant|DRUG: horse anti-thymocyte globulin (ATG)|DRUG: rabbit anti-thymocyte globulin (ATG)|DRUG: methotrexate|DRUG: fludarabine|DRUG: cyclophosphamide|RADIATION: low-dose total body irradiation (TBI)|PROCEDURE: Immunosuppressive Therapy (IST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Adjuvant Nonavalent HPV Vaccination in Women Treated for Vulvar HSIL
Status: NOT_YET_RECRUITING
Conditions: Vulvar HSIL|HPV
Interventions: DRUG: Gardasil 9 Suspension for Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial to Evaluate Pharmacokinetic Characteristics of MIT-001 After SC Administration in Healthy Subjects
Status: COMPLETED
Conditions: Heathly Subjects
Interventions: DRUG: Single subcutaneous administration and Blood collection|DRUG: Single subcutaneous administration and then IV injection.|DRUG: MIT-001 20mg and 40mg_Multiple administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of Clinical Approaches to Accelerate Orthodontic Tooth Movement
Status: COMPLETED
Conditions: Orthodontic Tooth Movement
Interventions: PROCEDURE: Piezocision|PROCEDURE: Corticotomy|DEVICE: Control Side|PROCEDURE: Micro-osteoperforations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pulsed Dye Laser (PDL) vs. Microsecond 1064-nm Nd:YAG Laser for Treatment of Diffuse Facial Redness
Status: COMPLETED
Conditions: Rosacea
Interventions: PROCEDURE: Pulse Dye Laser/YAG laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Bioavailability of Single Subcutaneous Doses of Methylnaltrexone Versus Intravenous Dose
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: SC Methylnaltrexone (MNTX)|DRUG: SC Methylnaltrexone (MNTX)|DRUG: SC Methylnaltrexone (MNTX)|DRUG: IV Methylnaltrexone (MNTX)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Brief Communal Coping Intervention for Adults With Type 2 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Communal Coping Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate eFFIcacy and Safety of Sublingual TNX-102 SL Tablet Taken at Bedtime in Patients With fibRoMyalgia
Status: COMPLETED
Conditions: Fibromyalgia|Myofascial Pain Syndromes|Muscular Diseases|Musculoskeletal Diseases|Nervous System Diseases|Neuromuscular Diseases|Rheumatic Diseases
Interventions: DRUG: TNX-102 SL Tablet, 2.8mg|DRUG: Placebo SL Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of BMS-986315 and Nivolumab in Combination With Chemotherapy in Participants With First-line Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)
Status: ACTIVE_NOT_RECRUITING
Conditions: NSCLC
Interventions: DRUG: BMS-986315|DRUG: Nivolumab|DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Virtual Reality Game for Pediatric Pain and Anxiety Management During Skin Prick Testing
Status: RECRUITING
Conditions: Acute Pain
Interventions: BEHAVIORAL: Experimental: Virtual Reality (VR) distraction|BEHAVIORAL: Active Comparator: Distraction by the book
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigation of Antidepressant Efficacy of Oral Ketamine Treatment
Status: UNKNOWN
Conditions: Major Depressive Episode
Interventions: DRUG: Ketamine|DRUG: Midazolam Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Pharmacokinetics of Different Formulations of Evobrutinib in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ref (TF2)|DRUG: Evobrutinib MR-T1|DRUG: Evobrutinib MR-T2|DRUG: Evobrutinib MR-T3|DRUG: Evobrutinib MR-T4|DRUG: Evobrutinib MUPS-C1|DRUG: Evobrutinib MUPS-C2|DRUG: Evobrutinib MUPS-C3|DRUG: Evobrutinib MUPS-C4|DRUG: Evobrutinib MR-T adapated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Standard and High Dose Irinotecan Based on UGT1A1 Genotype for First-line Treatment of Locally Advanced Colon Cancer
Status: UNKNOWN
Conditions: Colonic Neoplasms
Interventions: DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Immune Response Using 2 Vaccination Schedules Using Inactivated Polio Vaccine
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: Vaccination with inactivated polio vaccine|PROCEDURE: Collection of serum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed ES-SCLC Patients in Combination With Carboplatin, Etoposide and Atezolizumab
Status: RECRUITING
Conditions: Extensive Stage Small Cell Lung Cancer
Interventions: DRUG: [177Lu]Lu-DOTA-TATE|DRUG: Atezolizumab|DRUG: [68Ga]Ga-DOTA-TATE|OTHER: Carboplatin|OTHER: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reliability of Subcutaneous Echogenicity (SEG) Grade and Subcutaneous Echo-free Space (SEFS) Grade
Status: COMPLETED
Conditions: Postmastectomy Lymphedema Syndrome
Interventions: DIAGNOSTIC_TEST: Ultrasonographic assessment of postmastectomy lymphedema
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Efficacy Between 100% Platelet-rich Plasma and 100% Serum Eye Drops in Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: 100% Autologous platelet rich plasma|DRUG: 100% Autologous serum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of ssCART-19 Cells in Patients With CD19 Positive Relapsed or Refractory Acute Lymphoblastic Leukemia
Status: RECRUITING
Conditions: Relapsed or Refractory Acute Lymphoblastic Leukemia
Interventions: GENETIC: ssCART-19 Cells|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Vanzacaftor/Tezacaftor/Deutivacaftor (VNZ/TEZ/D-IVA) in Healthy Adult Panelists
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: VNZ/TEZ/D-IVA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lamivudine and Plasma Markers of Inflammation in Retinal Detachment
Status: RECRUITING
Conditions: Retinal Detachment|Rhegmatogenous Retinal Detachment
Interventions: DRUG: Lamivudine 300 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Increased Oxytocin Doses on the Mode of Delivery in Obese Primiparous Women With Spontaneous or Induced Labour
Status: RECRUITING
Conditions: Obese|Primiparous Women|Oxytocin
Interventions: DRUG: Oxytocin 4 mIU/mL|DRUG: Oxytocin 2 mIU/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Compassionate Use Protocol of AMX0035 for Treatment of Patients With Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: AMX0035
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Preliminary Efficacy Study of CC-99282 in Combination With Obinutuzumab in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: CC-99282|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3457263 in Obese Participants
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: DRUG: LY3457263|DRUG: Tirzepatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Nonunion Fractures With Mesenchymal Stromal Cells (MSCs)
Status: ENROLLING_BY_INVITATION
Conditions: Pseudoarthrosis of Bone|Pseudarthrosis|Non Union Fracture|Nonunion Bone Fracture
Interventions: BIOLOGICAL: Transplantation of autologous MSCs in nonunion fracture|BIOLOGICAL: Transplantation of allogeneic MSCs in nonunion fracture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diathermy Effectiveness in Reducing Subcutaneous Adipose Tissue Affected by Lipedema
Status: NOT_YET_RECRUITING
Conditions: Lipedema
Interventions: OTHER: Diathermy|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Durvalumab and Guadecitabine in Advanced Kidney Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Kidney Cancer|Kidney Cancer|Clear Cell Renal Cell Carcinoma
Interventions: DRUG: Guadecitabine|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of XZP-3287 in Metastasis Solid Tumors
Status: UNKNOWN
Conditions: Metastasis Solid Tumors|Advanced Breast Cancer
Interventions: DRUG: XZP-3287
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo Effects on Blood Pressure Induced by Expectancy Manipulation
Status: COMPLETED
Conditions: Blood Pressure
Interventions: DRUG: Placebo globuli|DRUG: Histaminum hydrochloricum globuli
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy Study of A Novel Ointment to Treat Plaque Type Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: AN2728|DRUG: Ointment vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT