pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Randomised Trial of Pulmonary Metastasectomy in Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Pulmonary Metastases
Interventions: PROCEDURE: Metastasectomy|PROCEDURE: Active monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Nasal Insulin to Fight Forgetfulness - Short-Acting Insulin Aspart
Status: COMPLETED
Conditions: Alzheimer's Disease|Mild Cognitive Impairment
Interventions: DRUG: Insulin aspart|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of ELDOA and Slump Stretching on Mechanical Low Back Pain
Status: RECRUITING
Conditions: Low Back Pain, Mechanical
Interventions: PROCEDURE: Conventional Physical Therapy|PROCEDURE: Slump Stretching|PROCEDURE: ELDOA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Adavosertib (MK-1775) in Combination With Paclitaxel and Carboplatin Versus Paclitaxel and Carboplatin Alone for Participants With Platinum-Sensitive Ovarian Tumors With the P53 Gene Mutation (MK-1775-004)
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: adavosertib|DRUG: Placebo|DRUG: paclitaxel|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Inotuzumab Ozogamicin in the Treatment of MRD+ After HSCT of ALL
Status: RECRUITING
Conditions: ALL|MRD-positive|Hematopoietic Stem Cell Transplantation
Interventions: DRUG: Inotuzumab Ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nicotine Related Brain Activity: The Influence of Smoking History and Blood Nicotine Levels
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: DRUG: Intravenous Nicotine|OTHER: Saline - placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Trial of Three- and Seven-days Insulin Infusions Set
Status: RECRUITING
Conditions: Type 1 Diabetes
Interventions: DEVICE: Mio Advanced infusions set|DRUG: Novorapid|DEVICE: Extended wear insulin infusion (EWIS)|DRUG: Humalog
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized,Double-blind,Placebo-controlled Clinical Study to Explore the Mechanism of Action of ON101 Cream in Patients With DFUs.
Status: COMPLETED
Conditions: Diabetic Foot Ulcers
Interventions: DRUG: ON101 Cream|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer
Status: SUSPENDED
Conditions: Advanced Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm|Refractory Malignant Solid Neoplasm|Triple-Negative Breast Carcinoma|Unresectable Malignant Solid Neoplasm
Interventions: DRUG: BET Bromodomain Inhibitor ZEN-3694|DRUG: Binimetinib|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of Women With Severe Diarrhea-Predominant Irritable Bowel Syndrome Having Failed Conventional Therapy
Status: COMPLETED
Conditions: Irritable Colon|Irritable Bowel Syndrome (IBS)
Interventions: DRUG: Alosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: An Investigation of Oral BT051 in Subjects With Moderately to Severely Active Ulcerative Colitis (UC)
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: BT051 200 mg|DRUG: BT051 800 mg|DRUG: BT051 3200 mg|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Best Method for ACL Reconstruction.
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Reconstruction
Interventions: PROCEDURE: ACL reconstruction hamstrings|PROCEDURE: ACL reconstruction patella tendon|PROCEDURE: ACL reconstruction iliotibial tract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Knee Arthrosis With Platelet-derived Growth Factors vs. Hyaluronic Acid.
Status: COMPLETED
Conditions: Knee Osteoarthrosis
Interventions: BIOLOGICAL: intraarticular injections of platelet lysate|DRUG: hyaluronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PFO Occlusion and Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation New Onset|Embolic Stroke of Undetermined Source|Patent Foramen Ovale
Interventions: PROCEDURE: PFO closure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Couple-oriented Prenatal HIV Counseling in Low and Medium HIV Prevalence Countries
Status: COMPLETED
Conditions: Partner HIV Testing|Couple HIV Counseling|Couple Communication|HIV Incidence
Interventions: BEHAVIORAL: Couple-oriented post-test HIV counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Motivational, Affective and Performance Effects of Caffeine Supplementation
Status: RECRUITING
Conditions: Caffeine|Affect|Goals
Interventions: DIETARY_SUPPLEMENT: Caffeine|DIETARY_SUPPLEMENT: Placebo|OTHER: No substance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: AMG 162 in the Treatment of Bone Loss in Subjects Undergoing Aromatase Inhibitor Therapy for Non-metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Low Bone Mineral Density|Osteopenia
Interventions: DRUG: Placebo|DRUG: AMG 162 / Denosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Public Health Nurse-Delivered 1-Day CBT Workshops Pilot
Status: COMPLETED
Conditions: Postpartum Depression
Interventions: BEHAVIORAL: 1-Day Cognitive Behavioural Therapy-Based Workshop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluticasone Furoate Nasal Spray Versus Oral Fexofenadine
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal
Interventions: DRUG: Fluticasone furoate and fexofenadine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Coenzyme Q10 in Relation to the Antioxidative Vitamins, Oxidative Stress and Inflammation in Coronary Artery Disease Patients During Statin Therapy
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DIETARY_SUPPLEMENT: Coenzyme Q10|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Non-invasive Phrenic Nerve Neuromodulation in Subjects With Inflammatory Bowel Disease and Neck Pain.
Status: ACTIVE_NOT_RECRUITING
Conditions: Inflammatory Bowel Diseases|Neck Pain
Interventions: DEVICE: Non-invasive Neuromodulation|OTHER: Cervico-dorsal Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Antiretroviral Treatment Simplified Follow-up Management Assessment (ANRS 12110 STRATALL)
Status: COMPLETED
Conditions: HIV Infections|AIDS
Interventions: PROCEDURE: Simplified follow-up approach of ARV treatment|PROCEDURE: Standard follow-up approach of ARV treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fasting Comparative Bioavailability of Two Tablet Formulations of Levodopa /Benserazide in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Levodopa + benserazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: NAVISTAR® THERMOCOOL® SF Catheter: Observational Study
Status: COMPLETED
Conditions: Atrial Fibrillation|Paroxysmal Arrhythmia
Interventions: DEVICE: Catheter Ablation (NAVISTAR® THERMOCOOL® SF Catheter)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Performance of Dynamic Elastic Response Feet
Status: COMPLETED
Conditions: Transtibial Amputation - Unilateral
Interventions: DEVICE: Fiberglass Composite foot|DEVICE: Carbon Fiber Composite Foot
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke (DIAS-4)
Status: TERMINATED
Conditions: Stroke
Interventions: DRUG: Desmoteplase|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Coparenting, Infant Sleep, and Infant Development
Status: UNKNOWN
Conditions: Sleep|Parenting|Marital Relationship|Parent-Child Relations
Interventions: BEHAVIORAL: Infant sleep-adapted coparenting intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Isotretinoin, Interferon Alfa, and Vitamin E in Treating Patients With Stage III or Stage IV Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: recombinant interferon alfa|DIETARY_SUPPLEMENT: vitamin E|DRUG: isotretinoin|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of the Safety and Efficacy of Peripheral Nerve Stimulation in the Treatment of Postherpetic Neuralgia.
Status: RECRUITING
Conditions: Neuropathic Pain|Postherpetic Neuralgia
Interventions: DEVICE: Active electrostimulation|DEVICE: Placebo electrostimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HFNC During Awake Craniotomy - Impact on Patient Comfort
Status: COMPLETED
Conditions: Pulmonary Atelectasis|Patient Comfort
Interventions: DEVICE: HFNC|DEVICE: Oxygen Mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0229, Pulmonary Rehabilitation Education w/wo Exercise Training in Improving Physical Function in Patients Who Are Undergoing Chemo & RT for Locally Advanced Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer|Pulmonary Complications
Interventions: OTHER: educational intervention|OTHER: supervised exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: The Efficacy and Safety of CUNOX® in Patients With Moderate to Severe Glabellar Lines
Status: COMPLETED
Conditions: Glabellar Frown Lines
Interventions: DRUG: Cunox|DRUG: Botox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating 6-months of HER2-targeted Therapy in Patients With HER2 Positive Early-stage Breast Cancer That Achieve a Pathological Complete Response to Neoadjuvant Systemic Therapy
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tcelna (Imilecleucel-T) in Secondary Progressive Multiple Sclerosis
Status: COMPLETED
Conditions: Autoimmune Diseases of the Nervous System|Multiple Sclerosis|Secondary Progressive Multiple Sclerosis|Disease Progression|Brain Atrophy
Interventions: BIOLOGICAL: Tcelna|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cisplatin, Capecitabine, and Radiation Therapy With or Without Cetuximab in Treating Patients With Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: capecitabine|DRUG: cisplatin|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy With or Without Total-Body Irradiation Prior to Bone Marrow Transplantation in Treating Children With Acute Lymphoblastic Leukemia
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: etoposide|DRUG: methotrexate|PROCEDURE: allogeneic bone marrow transplantation|RADIATION: Total Body Irradiation|DRUG: Busulfan|DRUG: Mesna|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Personalized Treatment Algorithms for Difficult-to-treat Asthma
Status: COMPLETED
Conditions: Asthma in Children
Interventions: DRUG: Cholecalciferol|DRUG: antihistamine|DRUG: Azithromycin|DRUG: emollient cream|DRUG: Fluticasone Propionate|DRUG: Asthma Controller Medication
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of a Single Dose of Digoxin on the Actions in the Bodies of Healthy Subjects After Having Taken Several Doses of YM178
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: YM178 OCAS|DRUG: Digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Respiratory Exercises Versus Manual Therapy and Respiratory Exercises in Moderate Smokers
Status: COMPLETED
Conditions: Manual Therapies|Respiratory Muscle Training|Exercise Therapy|Inspiratory Capacity
Interventions: OTHER: Inspiratory Muscle training|OTHER: IMT + Manual Therapy and Motor Control Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeted Literature Review and Subject Interviews in Wiskott-Aldrich Syndrome (WAS)
Status: COMPLETED
Conditions: Wiskott-Aldrich Syndrome
Interventions: OTHER: Patient Interview guide|OTHER: Caregiver interview guide|OTHER: Sociodemographic questionnaire|OTHER: Pediatric quality of life (PedsQL) questionnaire|OTHER: Clinical questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Core Stabilization Exercises in Women With Stress and Mixed Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: BEHAVIORAL: Core stabilization exercises with Kegel exercises|BEHAVIORAL: Kegel exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a Surface Antigen, Inactivated, Adjuvanted With MF59C.1, Seasonal Influenza Vaccine, Formulation 2009-2010
Status: COMPLETED
Conditions: Seasonal Influenza
Interventions: BIOLOGICAL: Seasonal Influenza Vaccine (MF59C.1)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study the Effect of Blood Transfusion on Oxidant-antioxidant Status in Term and Near-term Neonates
Status: COMPLETED
Conditions: Blood Transfusion Complication|Oxidative Stress
Interventions: BIOLOGICAL: packed red blood cells transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Light Therapy in End Stage Kidney Disease
Status: NOT_YET_RECRUITING
Conditions: End Stage Renal Disease
Interventions: DEVICE: Bright light|DEVICE: Dim Light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hemostasis Assesment After Application of Lyophilisate Collagen in Nail Surgery
Status: UNKNOWN
Conditions: Nails, Ingrown|Coagulation Defect; Bleeding
Interventions: DEVICE: collagen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise and Brain Vascular Function
Status: COMPLETED
Conditions: Physical Exercise|Cerebrovascular Function|Cerebral Blood Flow|Glucose Metabolism|Cognitive Performance
Interventions: OTHER: Aerobic-based exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Gemcitabine and Oxaliplatin as Second-Line Therapy in Treating Patients With Metastatic Colon Cancer
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant DPX-Survivac Aromatase Inhibition, Radiotherapy or Cyclophosphamide in HR+HER2- Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: BIOLOGICAL: DPX-Survivac|DRUG: Letrozole 2.5mg|DRUG: Cyclophosphamide 50mg|RADIATION: XRT 10Gy x2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Trial of Concurrent Chemotherapy Alone in Patients With Low-risk Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: RADIATION: IMRT and concurrent cisplatin|DRUG: gemcitabine and cisplatin (Induction chemotherapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AStudy to Evaluate the Bioavailability of PF 04965842 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-04965842|DRUG: PF-04965842|DRUG: PF- 04965842
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety Study of Candidate Malaria Vaccine FMP1/AS02A in Healthy Adults in Bandiagara, Mali
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: FMP1/AS02A|BIOLOGICAL: Imovax Rabies Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability of ToleroMune Grass in Grass Allergic Subjects With Rhinoconjunctivitis
Status: COMPLETED
Conditions: Allergy
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: ToleroMune Grass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of a Community Health Worker Program on Hearing Loss (Oyendo Bien)
Status: UNKNOWN
Conditions: Hearing Loss
Interventions: BEHAVIORAL: community health worker-audiologist communication education and support group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Can Acupuncture Treat Post-stroke Depression?
Status: COMPLETED
Conditions: Stroke|Depression|Stroke Sequelae
Interventions: PROCEDURE: Dense cranial electroacupuncture stimulation|PROCEDURE: Body acupuncture|DRUG: Antidepressant|OTHER: Rehabilitation|PROCEDURE: Least acupuncture stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Transplantation for Patients With Cancers of the Blood
Status: COMPLETED
Conditions: CML (Chronic Myelogenous Leukemia)|CLL (Chronic Lymphocytic Leukemia)|AML (Acute Myelogenous Leukemia)|Acute Lymphocytic Leukemia|MDS (Myelodysplastic Syndrome)
Interventions: COMBINATION_PRODUCT: Miltenyi system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bilateral Dual Transversus Abdominis Plane Block for Robotic Assisted Laparoscopic Surgery
Status: TERMINATED
Conditions: Pain Treatment|Robotic Assisted Laparoscopic Surgery|Bilateral Dual Transversus Abdominis Plane Block
Interventions: DRUG: Ropivacaine|DRUG: Isotonic potassium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Early Respiratory Rehabilitation in the Exacerbations of Re-admitted COPD Patients
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: PROCEDURE: Early Respiratory Rehabilitation Program|PROCEDURE: Conventional Respiratory Rehabilitation Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab and Ipilimumab in Treating Patients With HIV Associated Relapsed or Refractory Classical Hodgkin Lymphoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery
Status: RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Anal Carcinoma|HIV Infection|Kaposi Sarcoma|Lung Carcinoma|Metastatic Malignant Solid Neoplasm|Recurrent Classic Hodgkin Lymphoma|Refractory Classic Hodgkin Lymphoma|Unresectable Solid Neoplasm
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Computed Tomography|BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Efficacy of Immunoglobulin Plus Steroid for Prevention of Coronary Artery Abnormalities in Taiwanese Refractory Kawasaki Disease (RAST Study)
Status: UNKNOWN
Conditions: Kawasaki Disease|Steroid|Immuoglobulin
Interventions: DRUG: Prednisolone|BIOLOGICAL: immunoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-escalation Study to Assess Safety and Pharmacokinetics of Nab-Sirolimus in Patients With Locally Advanced or Metastatic Solid Tumors and Moderate Liver Impairment
Status: RECRUITING
Conditions: Tumor, Solid|Tumor|Advanced Solid Tumor
Interventions: DRUG: nab-sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Usability of c-SIGHT in the Homes of Brain Injury Survivors
Status: UNKNOWN
Conditions: Stroke|Brain Injuries|Spatial Neglect|Attention Deficit
Interventions: BEHAVIORAL: c-SIGHT (computorized spatial innatention grasping home-based therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Just-in-time Adaptive Intervention Messaging in a Digital Weight Loss Intervention for Young Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Overweight|Overweight and Obesity
Interventions: BEHAVIORAL: Core Behavioral Weight Loss (BWL) Intervention|BEHAVIORAL: Behavior Change Technique 1 Message (Action Planning)|BEHAVIORAL: Behavior Change Technique 2 Message (Discrepancy between Current Behavior and Goal)|BEHAVIORAL: Behavior Change Technique 3 Message (Feedback on Outcome of Behavior)|BEHAVIORAL: Behavior Change Technique 4 Message (Social Support)|BEHAVIORAL: Behavior Change Technique 5 Message (Social Comparison)|BEHAVIORAL: Behavior Change Technique 6 Message (Social Reward)|BEHAVIORAL: Behavior Change Technique 7 Message (Focus on Past Success)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Muscle-Tendon Mechanics During Locomotor Tasks, Efficacy of Collagen Supplementation for Older Adults
Status: COMPLETED
Conditions: Tendon Stiffness With Age
Interventions: DIETARY_SUPPLEMENT: Collagen supplement group|DIETARY_SUPPLEMENT: Placebo supplement group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of All-Trans Retinoic Acid (ATRA) and Bryostatin in Patients With Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: All-trans retinoic acid|DRUG: Bryostatin 1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 21 Day Comparison of Continuous Insulin Infusion Using HDV Insulin to Standard Insulin in Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type1 Diabetes Mellitus
Interventions: DRUG: HDV insulin lispro 100 UNIT/mL|DRUG: Insulin Lispro 100 Units/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers in Patients With Rectal Cancer Undergoing Chemotherapy and Radiation Therapy
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: capecitabine|DRUG: 5-fluorouracil|PROCEDURE: Surgical Resection|RADIATION: Radiation therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease
Status: RECRUITING
Conditions: Crohn's Disease
Interventions: DRUG: TAK-279|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Mulberry Juice on Inflammatory Status and Clinical Symptoms in Patients With General Anxiety Disorder
Status: UNKNOWN
Conditions: General Anxiety Disorders|Systemic Inflammation|Interleukin
Interventions: OTHER: Mulberry juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Obesity on Glutathione Levels in Patients With Chronic Periodontitis Before and After Periodontal Therapy
Status: COMPLETED
Conditions: Obesity
Interventions: PROCEDURE: nonsurgical periodontal therapy|PROCEDURE: oral hygiene instructions|PROCEDURE: nonsurgical periodontal therapy|PROCEDURE: oral hygiene instructions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Analgesia Nociception Index With Varying Remifentanil Concentrations Under Sevoflurane
Status: COMPLETED
Conditions: General Anesthesia
Interventions: DEVICE: Tetanic stimulation|PROCEDURE: Skin incision
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Propranolol for the Treatment of Traumatic Brain Injury
Status: NOT_YET_RECRUITING
Conditions: TBI (Traumatic Brain Injury)
Interventions: DRUG: Propranolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Effect of Itraconazole on the Pharmacokinetics of Rilapladib (SB659032) in Healthy Volunteers
Status: WITHDRAWN
Conditions: Alzheimer's Disease
Interventions: DRUG: Rilapladib 25 mg|DRUG: Rilapladib 250 mg|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Continuing Tenofovir, Emtricitabine (or Lamivudine) Plus Lopinavir and Switching to Raltegravir Plus Darunavir
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Raltegravir, Darunavir/r
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Duration and Blood Pressure During Sleep
Status: ACTIVE_NOT_RECRUITING
Conditions: Blood Pressure|Hypertension|Elevated Blood Pressure|Sleep|Short Sleep Phenotype
Interventions: BEHAVIORAL: Sleep hygiene/extension intervention|BEHAVIORAL: Control care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 2a Study of CG400549 for the Treatment of cABSSSI Caused by Methicillin-resistant Staphylococcus Aureus
Status: COMPLETED
Conditions: Skin Infection
Interventions: DRUG: CG400549
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using NPT to Evaluate Providing PPC as ELNEC-PPC WBT for Nurses
Status: UNKNOWN
Conditions: Cancer|Cardiac Anomaly|Cystic Fibrosis|Muscular Dystrophy|HIV/AIDS|Batten's Disease|Cerebral Palsy
Interventions: GENETIC: end-of-life nursing education consortium-pediatric palliative care as web based-training plus usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A PROSPECTIVE, MULTI-CENTER, PHASE 4 STUDY TO ASSESS THE SAFETY OF TRASTUZUMAB DERUXTECAN, AN ANTI-HER2-ANTIBODY DRUG CONJUGATE IN INDIAN PATIENTS WITH UNRESECTABLE OR METASTATIC HER2-POSITIVE BREAST CANCER WHO HAVE RECEIVED A PRIOR ANTI-HER2-BASED REGIMEN
Status: NOT_YET_RECRUITING
Conditions: BREAST CANCER
Interventions: DRUG: Trastuzumab deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Tolerability and Efficacy of Different Doses of Duloxetine for the Treatment of Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder
Interventions: DRUG: duloxetine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate HL-TOF Tab. 5 mg Compared With XelJanz Tab. in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: HL-TOF tab. 5mg|DRUG: Xeljanz tab. 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Dexmedetomidine on Emergence Agitation in Children Undergoing a Surgery Under Desflurane Anesthesia
Status: UNKNOWN
Conditions: Psychomotor Agitation
Interventions: DRUG: Dexmedetomidine|DRUG: 0.9% Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Spinous Balloon Dilatation Catheter in CAD Treatment
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: spinous balloon dilatation catheter (Plastic-Blade)|PROCEDURE: spinous balloon dilatation catheter(lacrosse NSE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase Ib/II Study of SHR-A1811 Injection in Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: SHR-A1811：Pyrotinib|DRUG: SHR-A1811；Pertuzumab|DRUG: SHR-A1811；Adebrelimab|DRUG: SHR-A1811；Albumin paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tenecteplase Versus Alteplase Before Endovascular Therapy for Ischemic Stroke
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: Tenecteplase|DRUG: Tissue Plasminogen Activator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Atrioventricular Delay Pacing
Status: WITHDRAWN
Conditions: Chronically (i.e. Implanted for at Least Six Months) Dual-chamber Pacemaker|Stable Cardiac Status (i.e. no Hospitalizations or Cardiac Medication Changes Within 3 Months)
Interventions: OTHER: short AVD pacing ; prior (stable) programming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Endoscopic Submucosal Dissection (ESD)- Master Slave Robotic System - Human Study
Status: COMPLETED
Conditions: Endoscopic Submucosal Dissection
Interventions: DEVICE: ESD using Master Slave Robotic System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the RevLite Electro-optic Q-Switched Neodymium-doped Yttrium Aluminium Garnet (EO QS Nd:YAG) Laser to a Fractionated Laser System
Status: COMPLETED
Conditions: Photodamage|Irregular Pigmentation|Acne Scars
Interventions: PROCEDURE: RevLite laser treatment|PROCEDURE: Fractionated Laser treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of TRIFLURIDINE/TIPIRACIL in Previously Treated Cholangiocarcinoma
Status: TERMINATED
Conditions: Cholangiocarcinoma|Bile Duct Cancer
Interventions: DRUG: Trifluridine/Tipiracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Para-vertebral Dexmedetomidine and the Incidence of Postoperative Chronic Pain
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Dexmedetomidine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lamotrigine as Treatment of Myotonia
Status: COMPLETED
Conditions: Dystrophia Myotonica Type 1|Myotonia Congenita|Paramyotonia Congenita|Hyperkalemic Periodic Paralysis|Potassium-Aggravated Myotonia
Interventions: DRUG: Lamotrigine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: POsition of Leads in Advanced heaRt Failure: the POLAR Study
Status: UNKNOWN
Conditions: Cardiac Resynchronization Therapy|Heart Failure
Interventions: PROCEDURE: Postero-lateral|PROCEDURE: Antero-Lateral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Otiprio Versus Ciprodex Tympanostomy Tube Outcomes
Status: WITHDRAWN
Conditions: Otorrhea|Otitis Media With Effusion in Children
Interventions: DRUG: Otiprio|DRUG: Ciprodex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet Transdiagnostic-CBT for Anxiety and Depression in Adolescents
Status: COMPLETED
Conditions: Anxiety Disorder|Depressive Disorder|Emotional Disorder
Interventions: BEHAVIORAL: The AMTE protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Cannabinoids on Pain in Fabry Disease Patients
Status: RECRUITING
Conditions: Pain, Neuropathic
Interventions: DRUG: Cannabis sativa L., folium cum flore|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Surgical Treatment of Elderly Patients With cT1N0M0 Non-small Cell Lung Cancer Comparison Between Sublobar Resection and Lobectomy
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: PROCEDURE: VATS|PROCEDURE: Thoracotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quincy Family, Youth & Technology For Lifestyle Change (FYT-4-LIFE) Study
Status: COMPLETED
Conditions: Pediatric Obesity
Interventions: OTHER: Physical Activity|BEHAVIORAL: Evidence-based information on healthy family routines
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of RX-af01 Combined With PD-1 Antibody
Status: RECRUITING
Conditions: Solid Tumor|Immune Checkpoint Inhibitor|Intestinal Flora
Interventions: DRUG: RX-af01|DRUG: Mixed bacteria|DRUG: High dose RX-af01
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antibiotic Treatment for 7 Days Versus 14 Days in Patients With Acute Male Urinary Tract Infection
Status: COMPLETED
Conditions: Acute Male Urinary Tract Infection
Interventions: DRUG: Ceftriaxone|DRUG: Ofloxacine|DRUG: Ofloxacine|DRUG: Placebo of ofloxacine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Label Dose Escalation Safety Study of Convection-Enhanced Delivery of IL13-PE38QQR in Patients With Progressive Pediatric Diffuse Infiltrating Brainstem Glioma and Supratentorial High-grade Glioma
Status: TERMINATED
Conditions: Brain Neoplasm|Glioma
Interventions: DRUG: IL13-PE38QQR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Efficacy of an Adeno-Associated Viral Vector Carrying the SMN Gene After a Single Intravenous Administration of Escalating Doses in Children With Spinal Muscular Atrophy (BLUEBELL)
Status: RECRUITING
Conditions: Spinal Muscular Atrophy (SMA)
Interventions: GENETIC: ANB-004, dose 1|GENETIC: ANB-004, dose 2|GENETIC: ANB-004, dose 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of Different Doses Of TBC3711 In Patients With Uncontrolled High Blood Pressure Already Taking Medications For High Blood Pressure.
Status: TERMINATED
Conditions: Resistant Hypertension
Interventions: DRUG: Placebo|DRUG: TBC3711|DRUG: TBC3711|DRUG: TBC3711|DRUG: TBC3711
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of a Diagnostic Test for Glucose-6-phosphate Dehydrogenase (G6PD) Deficiency in Anti-coagulated Blood
Status: COMPLETED
Conditions: G6PD Deficiency
Interventions: DIAGNOSTIC_TEST: SD Biosensor STANDARD G6PD Test|DIAGNOSTIC_TEST: Pointe Scientific Test Kit|DIAGNOSTIC_TEST: HemoCue System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Odevixibat in Patients With Alagille Syndrome
Status: COMPLETED
Conditions: Alagille Syndrome
Interventions: DRUG: Odevixibat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Safety, and Tolerability of rhEGF Eye Drops in Healthy Male Subjects
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: Single dose of rhEGF 10mcg/ml or placebo|DRUG: Single dose of rhEGF 50mcg/ml or placebo|DRUG: Single dose of rhEGF 100mcg/ml or placebo|DRUG: Multiple dose of rhEGF 10mcg/ml or placebo|DRUG: Multiple dose of rhEGF 50mcg/ml or placebo|DRUG: Multiple dose of rhEGF 100mcg/ml or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Single Ascending Doses Study of Anti- Interleukin-7 Receptor α Monoclonal Antibody (GSK2618960) in Healthy Volunteers
Status: COMPLETED
Conditions: Autoimmune Diseases
Interventions: DRUG: GSK2618960|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Additive Effect of Endonase on Eradication Rate of First Line Therapy for Helicobacter Pylori
Status: COMPLETED
Conditions: Gastric Ulcer Associated With Helicobacter Pylori
Interventions: DRUG: Endonase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pericapsular Nerve Group Block on Positioning Pain for Spinal Anesthesia in Hip Fracture Patients
Status: COMPLETED
Conditions: Pain, Acute
Interventions: PROCEDURE: PENG Block|DRUG: Conventional opioid analgesia (Fentanyl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Repaglinide Combined With Insulin NPH in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: repaglinide|DRUG: insulin NPH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CSD210202: A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery Systems
Status: COMPLETED
Conditions: Smoking|Smoking Behaviors|Tobacco Use|Tobacco Smoking
Interventions: OTHER: Product A|OTHER: Product B|OTHER: Product C|OTHER: Product D|OTHER: Product E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Treatment for Sacroiliac Joint Pain Using Platelet-rich Plasma (PRP) Versus Steroid/Anesthetic
Status: RECRUITING
Conditions: Low Back Pain|Sacroiliac Joint Synovitis
Interventions: PROCEDURE: Sacroiliac intra-articular injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bromfenac to Reduce Inflammation in Patients With Pseudoexfoliation Syndrome After Cataract Surgery
Status: COMPLETED
Conditions: Cataract|Pseudoexfoliation Syndrome
Interventions: DRUG: Dexamethasone+Tobramycin eye drop|DRUG: Bromfenac eye drop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Vaginal PAMG-1 Detection by PartoSure Test in Preterm Delivery Threat in Actual Clinical Situation: Randomized Controlled Trial
Status: COMPLETED
Conditions: Pregnancy Preterm
Interventions: OTHER: Current care|DEVICE: PartoSure Test negative|DEVICE: PartoSure Test positive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Chemoradiotherapy With or Without Metformin in Locally Advanced Cervical Cancer
Status: NOT_YET_RECRUITING
Conditions: Cervical Cancer|Radiotherapy|Metformin|Hypoxia|PET/CT
Interventions: DRUG: Metformin|RADIATION: Radiotherapy|DRUG: Chemotherapy|DIAGNOSTIC_TEST: PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Access to Chiropractic Care During the COVID-19 Healthcare Emergency in Spain
Status: COMPLETED
Conditions: Musculoskeletal Pain|Disability Physical|Psychological Distress
Interventions: OTHER: Chiropractic care (one visit)|OTHER: Chiropractic care (more than one visit)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Travatan Versus Timoptic in Treating Open-angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Travoprost 0.004% Ophthalmic Solution (Travatan)|DRUG: Timolol 0.5% Ophthalmic Solution (Timoptic)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mini- Percutaneous Nephrolithotomy Versus Standard Percutaneous Nephrolithotomy in the Treatment of Renal Stones.
Status: UNKNOWN
Conditions: Urolithiasis|Stone;Renal|Nephrolithiasis|PNL|PCNL|NEPHROLITHOTOMY|MINIPERC
Interventions: PROCEDURE: MINI-PERCUTANEOUS NEPHROLITHOTOMY|PROCEDURE: STANDARD PERCUTANEOUS NEPHROLITHOTOMY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT