pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Dexamethasone to Treat Acute Chest Syndrome in People With Sickle Cell Disease
Status: TERMINATED
Conditions: Anemia, Sickle Cell
Interventions: DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of Donor Oocytes Semi-automated Vitrification
Status: RECRUITING
Conditions: Vitrification|Egg Donor|Fertility|Assisted Reproductive Technology
Interventions: DEVICE: Gavi, Merck® (automated vitrification instrument)|DEVICE: Vitrolife system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Trial of Intratumoral Injections of SD-101 in Combination With Pembrolizumab in Patients With Metastatic Melanoma or Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Status: TERMINATED
Conditions: Metastatic Melanoma|Head Neck Cancer
Interventions: DRUG: SD-101(1)|BIOLOGICAL: Pembrolizumab|DRUG: SD-101(2)|BIOLOGICAL: Pembrolizumab|BIOLOGICAL: SD-101(3)|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Association Between 4-Month Isokinetic Testing Measures and Second Knee Injuries After Primary Anterior Cruciate Ligament Reconstruction
Status: COMPLETED
Conditions: ACL Injury|Knee Injuries|Muscle Weakness
Interventions: DIAGNOSTIC_TEST: Return-to-sport (RTS) follow-up
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investıgatıon Of The Effect Of The Pandemıc Process In Indıvıduals Wıth Chronıc Low Back And Neck Paın
Status: COMPLETED
Conditions: Neck Pain|Low Back Pain|Cognitive Level|COVID-19 Pandemic
Interventions: OTHER: assessment of cognitive level, pain catastrophe, physical activity level and quality of life
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: IV Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy
Status: WITHDRAWN
Conditions: Pain, Postoperative|Analgesia|Postoperative Pain|Pain, Post Operative|Oxytocin
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Clinical Consistency of Three Production Lots of GSK Biologicals' HRV Vaccine
Status: COMPLETED
Conditions: Infections, Rotavirus
Interventions: BIOLOGICAL: Rotarix|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Follow-On Study of Pitavastatin Versus Atorvastatin in Patients With Type II Diabetes Mellitus and Combined Dyslipidemia
Status: COMPLETED
Conditions: Type II Diabetes Mellitus|Dyslipidemia
Interventions: DRUG: Pitavastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enalapril in Treating Heart Damage Patients Who Received Anthracycline Chemotherapy for Childhood Cancer
Status: COMPLETED
Conditions: Cardiac Toxicity|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: enalapril maleate|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mobile Phone Messaging to Improve Reproductive Health for Women Living With HIV in Kenya (Mobile WACh Empower)
Status: RECRUITING
Conditions: Hiv|Contraception|Fertility Issues
Interventions: BEHAVIORAL: Digital counseling plus interactive two-way SMS dialogue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluate Safety and Immunogenicity of a Vero Cell-Derived JE Vaccine in 9-24 Months of Age Children in Vietnam
Status: COMPLETED
Conditions: Japanese Encephalitis
Interventions: BIOLOGICAL: JEVAX|BIOLOGICAL: JECEVAX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of EPA and DHA-Rich Fish Oils on Lipoprotein Metabolism In Adults
Status: COMPLETED
Conditions: Lipoprotein Metabolism|PCSK9|Proteomics
Interventions: DRUG: EPA-rich fish oil|DRUG: DHA-rich fish oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Growth Study Using Else Toddler Nutritional Drink vs. a. Dairy Based Toddler Drink (Control) in Healthy Toddlers
Status: RECRUITING
Conditions: Weight Gain
Interventions: OTHER: Plant based toddler nutrition|DIETARY_SUPPLEMENT: Dairy based toddler nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate NT219 Alone and in Combination With ERBITUX® (Cetuximab) in Adults With Advanced Solid Tumors and Head and Neck Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor, Adult|Squamous Cell Carcinoma of Head and Neck|Colorectal Adenocarcinoma|Metastatic Solid Tumor|Recurrent Solid Tumor|Head and Neck Cancer
Interventions: DRUG: NT219|DRUG: NT219 and ERBITUX® - Dose Escalation|DRUG: NT219 and ERBITUX® - Expansion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In Vivo Efficacy of Salbutamol (Sandoz) Versus Salbutamol Ventolin (GSK) in Children With Asthma
Status: RECRUITING
Conditions: Agents, Anti Asthmatic|Asthma in Children
Interventions: DRUG: "100 mcg Salbutamol Sandoz" and "300 mcg Salbutamol Sandoz"|DRUG: "100 mcg Salbutamol Sandoz" and "300 mcg Salbutamol Ventolin GSK"|DRUG: "100 mcg Salbutamol Ventolin GSK" and "300 mcg Salbutamol Sandoz"|DRUG: "100 mcg Salbutamol Ventolin GSK" and "300 mcg Salbutamol Ventolin GSK"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Immune Persistence of GSK Biologicals' Combined Hepatitis A & B Vaccine Injected According to a 0,1,6 Mth Schedule in Healthy Adults
Status: COMPLETED
Conditions: Hepatitis B|Hepatitis A
Interventions: BIOLOGICAL: Twinrix™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Placebo-controlled Study to Investigate the Safety, and Pharmacokinetics of Oral GSK626616AC in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects|Anaemia
Interventions: DRUG: GSK626616, placebo, midazolam|DRUG: omeprazole, caffeine, flurbiprofen, rosiglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Safety Evaluation of an Experimental Treatment, Intradermal Human Fcγ1-Fel d1 Fusion Protein (GFD), for Cat Allergy
Status: TERMINATED
Conditions: Cat Allergy
Interventions: BIOLOGICAL: Intradermal Human Fcγ1-Fel d1 fusion protein|BIOLOGICAL: Positive Control - standardized cat hair allergenic extract (CAT)|BIOLOGICAL: Positive Control - Histamine Prick|BIOLOGICAL: Negative Control - Intradermal Diluent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Sleep Quality on Melatonin Levels and Inflammatory Response After Major Abdominal Surgery
Status: UNKNOWN
Conditions: Sleep Deprivation
Interventions: BEHAVIORAL: Dimming of lights and decreasing noise level|DRUG: Bupivacaine (Bustesin®) via Pain Buster ® system|DRUG: Tramadol HCl (Tramosel®) via PCA system (Gemstar®)|PROCEDURE: Major abdominal surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Compare Efficacy and Tolerability of Fulvestrant 250mg, 250mg Plus 250mg Loading Regimen and 500mg
Status: COMPLETED
Conditions: Advanced Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Patient Positioning for Perineal Protection Study
Status: UNKNOWN
Conditions: Perineal Tear|Delivery; Trauma|Perineal Laceration
Interventions: OTHER: Hip extension|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Batefenterol/Fluticasone Furoate in Treatment of Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Batefenterol + Fluticasone Furoate|DRUG: Placebo|DRUG: Albuterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacists as Immunizers to Improve Coverage and Provider/Recipient Satisfaction
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Meningococcal B|BIOLOGICAL: High-Dose TIV|BIOLOGICAL: Tdap (tetanus-diphtheria-acellular pertussis)|BIOLOGICAL: Meningococcal ACWY|BIOLOGICAL: Herpes Zoster|BIOLOGICAL: Travel Health (Hepatitis A, Hepatitis B, Typhoid Fever)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Aveir AR Coverage With Evidence Development (CED) Study
Status: RECRUITING
Conditions: Cardiac Pacemaker|Arrhythmia|Bradycardia
Interventions: DEVICE: Aveir AR Leadless Pacemaker|DEVICE: Single-chamber atrial transvenous pacemaker
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Digitally Supported Lifestyle Programme to Promote Brain Health Among Older Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Cognitive Impairment|Cognitive Decline|Dementia
Interventions: BEHAVIORAL: Structured ICT-assisted multimodal lifestyle intervention|BEHAVIORAL: Self-guided multimodal lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Perioperative Oral Steroids for Chronic Rhinosinusitis Without Polyps (CRSsNP)
Status: COMPLETED
Conditions: Chronic Rhinosinusitis|Endoscopic Sinus Surgery|Chronic Rhinosinusitis Without Polyps|Oral Steroids
Interventions: DRUG: Prednisone|DRUG: Flonase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preterm Induction of Labor Timing of Amniotomy: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Preterm Pregnancy|Labor Induction
Interventions: PROCEDURE: Early Amniotomy|PROCEDURE: Late Amniotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-Guided Erector Spinae Plane Block Following Laparoscopic Sleeve Gastrectomy Surgery
Status: WITHDRAWN
Conditions: Obesity
Interventions: OTHER: ESP block (Group ESP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reproductive Health in Men and Women With Vasculitis
Status: COMPLETED
Conditions: Giant Cell Arteritis|Takayasu's Arteritis|Polyarteritis Nodosa|Wegener's Granulomatosis|Microscopic Polyangiitis|Churg-Strauss Syndrome|Behcet's Disease|Kawasaki Disease|Henoch-schoenlein Purpura|Vasculitis, Central Nervous System|Drug-induced Necrotizing Vasculitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trimetazidine Therapy in Hypertrophic Cardiomyopathy
Status: UNKNOWN
Conditions: Hypertrophic Cardiomyopathy
Interventions: DRUG: Trimetazidine|OTHER: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to IDEntify Patients With Advanced/Metastatic Non Small Cell Lung Cancer (NSCLC) and ALK and ROS1 Translocation and to Establish Their Therapeutic Management (IDEALK&ROS)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Crizotinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Laryngeal Motor Evoked-potentials as a Biomarker of Vagus Nerve Stimulation in Epileptic Patients
Status: UNKNOWN
Conditions: Epilepsy
Interventions: OTHER: Characterization of Vagus nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Splinting Interventions for Treating Mallet Finger Injuries
Status: UNKNOWN
Conditions: Mallet Finger
Interventions: DEVICE: Circumferential thermoplastic thimble splint|DEVICE: dorsal aluminium foam "Mexican Hat" splint|DEVICE: stack splint (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Lentiviral Gene Therapy for MLD
Status: UNKNOWN
Conditions: Metachromatic Leukodystrophy (MLD)
Interventions: BIOLOGICAL: Lentivirus-mediated delivery of ARSA to the CNS.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recanalization of Congenital Nasolacrimal Duct Obstruction by Endodiathermy Probe and Intubation Versus Intubation Only
Status: UNKNOWN
Conditions: Congenital Nasolacrimal Duct Obstruction
Interventions: PROCEDURE: Endodiathermy Probe and Intubation Versus Intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cells in Critical Limb Ischemia
Status: COMPLETED
Conditions: Critical Limb Ischemia
Interventions: DRUG: mesenchymal stem cells|DRUG: Plasmalyte A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Unstable Shoes on Trunk Muscle Activity, Lumbar Spine Kinematics and Pain in Patients With Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Unstable shoe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Letrozole and CDK 4/6 Inhibitor for ER Positive, HER2 Negative Breast Cancer in Postmenopausal Women
Status: UNKNOWN
Conditions: ER Positive, HER2 Negative Breast Cancer
Interventions: DRUG: Letrozole, PD 0332991
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Therapy on Orthodontic Tooth Movement
Status: COMPLETED
Conditions: Laser Therapy|Orthodontic Tooth Movement|Bone Remodeling
Interventions: DEVICE: Low-level Laser Therapy|PROCEDURE: Orthodontic force
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of MegaCarti® in Knee Cartilage Defects
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: MegaCarti®|PROCEDURE: Microfracture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxytocin and Interpersonal Motor Resonance
Status: COMPLETED
Conditions: Social Behavior
Interventions: DRUG: Oxytocin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Pyridostigmine With Ondansetron in Subjects With Anti-AchR Positive Myasthenia Gravis
Status: RECRUITING
Conditions: Myasthenia Gravis
Interventions: DRUG: DAS-001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Platelet Inhibition According to Clopidogrel Dose in Patients With Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease|Stable Angina
Interventions: DRUG: Clopidogrel, cilostazol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Self-Management Program and Survivorship Care Plan in Improving the Health of Cancer Survivors After Stem Cell Transplant
Status: COMPLETED
Conditions: Hematopoietic and Lymphoid Cell Neoplasm
Interventions: OTHER: Best Practice and Internet site with links to existing resources|OTHER: Internet, Mobile app and Telehealth Intervention|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetics of Nicotine Film in Smokers
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Nicotine Film|DRUG: Placebo Nicotine Film
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reward Circuit Modulation Via fMRI-informed-EEG-based Musical Neurofeedback
Status: UNKNOWN
Conditions: Healthy
Interventions: OTHER: Brain-computer-interface: EEG-based musical Neurofeedback task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Measuring Beliefs and Norms About Persons With Mental Illness
Status: COMPLETED
Conditions: Mental Illness|Schizophrenia|Bipolar Disorder|Depression
Interventions: OTHER: Survey questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacity of Corneal Collagen Crosslinking in Infectious Keratitis (Bacterial and Fungal ): Randomized,Controlled, Prospective Study. (CXL)
Status: TERMINATED
Conditions: Bacterial Keratitis|Fungal Keratitis
Interventions: DEVICE: Crosslinking|DRUG: antibiotic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TREXIMET® Versus Butalbital-containing Combination Medications for the Acute Treatment of Migraine in Adults
Status: COMPLETED
Conditions: Migraine Disorders|Migraine, Acute
Interventions: DRUG: TREXIMET®|DRUG: Butalbital-containing Combination Medications (BCM)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 5 Fractions of Pelvic SABR With Intra Prostatic SABR Boost:
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: Stereotactic Ablative Body Radiotherapy (SABR) 35-50 Gy/5
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Short-course Hypofractionated PBT for Non-metastatic RPS
Status: WITHDRAWN
Conditions: Retroperitoneal Sarcoma
Interventions: RADIATION: Hypofractionated Proton Beam Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Routine Electronic Monitoring Of Quality Of Life -Poumon (REMOQOL-Poumon)
Status: RECRUITING
Conditions: Lung Cancer|Non Small Cell Lung Cancer
Interventions: OTHER: Electronic HRQoL questionnaires with feedback to physicians|OTHER: Paper-pencil HRQoL questionnaires w.o. feedback to physicians
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Peanut Oral Immunotherapy Study: Safety, Efficacy and Discovery
Status: COMPLETED
Conditions: Peanut Allergy
Interventions: DRUG: Peanut Protein 4,000mg|DRUG: Oat Flour|DRUG: Peanut Protein 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interactions of Fronto-Parietal High Frequency rTMS on Anterior Cingulate Cortex Activation in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DEVICE: 20 Hz rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prediction of Hepatocellular Carcinoma Recurrence After Curative Treatment by Monitoring Circulating Tumor DNA
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: OTHER: circulating tumor DNA dosage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Docetaxel and Cisplatin in Treating Patients With Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer That Has Been Completely Removed By Surgery
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: docetaxel|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study Evaluating the Clinical Efficacy and Safety of GN-037 in Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: GN-037|DRUG: Clobetasol 17-propionate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Trial of Pembrolizumab and Androgen-receptor Pathway Inhibitor With or Without 225Ac-J591 for Progressive Metastatic Castration Resistant Prostate Cancer
Status: SUSPENDED
Conditions: Prostate Cancer
Interventions: DRUG: 225Ac-J591|DRUG: Pembrolizumab|DRUG: Androgen receptor pathway inhibitor|DIAGNOSTIC_TEST: 68Ga-PSMA-11
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases
Status: ENROLLING_BY_INVITATION
Conditions: Severe Combined Immunodeficiency (SCID)|Immunodeficiency With Predominant T-cell Defect, Unspecified|Severe Chronic Neutropenia|Chronic Granulomatous Disease (CGD)|Hyper IgE Syndromes|Hyper IgM Deficiencies|Wiskott-Aldrich Syndrome|Mendelian Susceptibility to Mycobacterial Disease|Common Variable Immune Deficiency (CVID)
Interventions: BIOLOGICAL: CD3/CD19 negative allogeneic hematopoietic stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wiring Adolescents With Social Anxiety Via Behavioral Interventions
Status: COMPLETED
Conditions: Social Anxiety
Interventions: OTHER: dCBGT + WASABI|OTHER: dCBGT Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: rTMS on Appetite and Cognitive Function in Schizophrenia
Status: ACTIVE_NOT_RECRUITING
Conditions: Schizophrenia
Interventions: DEVICE: iTBS|DEVICE: Shame stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: AI to Support Mental Health Case Management Providers
Status: ENROLLING_BY_INVITATION
Conditions: Depressive Disorder|Anxiety Disorders|Substance Use Disorders|Post Traumatic Stress Disorder
Interventions: OTHER: Artificial Intelligence platform for case managers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Pharmacokinetic Study of [14C]-GDC-0810 After Single Oral Administration in Healthy Female Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: [14C]-GDC-0810
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Stereotactic Body Radiation Therapy (SBRT) for Tumors Near the Spinal Cord
Status: COMPLETED
Conditions: Spinal Tumors
Interventions: RADIATION: Stereotactic Body Radiation Therapy|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Population-Based Study on Chlamydia Trachomatis Screening
Status: COMPLETED
Conditions: Chlamydia Trachomatis|Infertility|Ectopic Pregnancy
Interventions: BEHAVIORAL: Screening for urogenital Chlamydia trachomatis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Erector Spinae Plane Block As Alternative Analgesic Modality in Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Laparoscopic Cholecystectomy|Quadratus Lumborum Block|Erector Spinae Plane Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot of a Microdevice For In Situ Candidate Drug Screening in Cutaneous Lesions of T-Cell Lymphoma
Status: RECRUITING
Conditions: Cutaneous T Cell Lymphoma|Peripheral T Cell Lymphoma
Interventions: DEVICE: Microdevices|OTHER: Standard of care therapy|OTHER: Standard of care systemic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Endogenous Pain Modulation Mechanisms With Transcutaneous Electrical Nerve Stimulation
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DEVICE: Thermode(hot plate) and cold water bath|DEVICE: TENS(transcutaneous electrical nerve stimulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Vaccine Therapy Plus Radiation Therapy in Treating Patients With Non-small Cell Lung Cancer That Has Been Completely Removed in Surgery
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: monoclonal antibody 11D10 anti-idiotype vaccine|BIOLOGICAL: monoclonal antibody 3H1 anti-idiotype vaccine|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Dose-escalation, Expansion Study of ARX788, in Advanced Solid Tumors Subjects With HER2 Expression (ACE-Pan Tumor 01)
Status: COMPLETED
Conditions: Breast Neoplasms|Gastric Neoplasm|Solid Tumors
Interventions: DRUG: ARX788
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Effect on Quality of Recovery Outcome Between Systemic Lidocaine and Dexamethasone in Patients Undergoing Laparoscopic Cholecystectomy
Status: TERMINATED
Conditions: Gallbladder Polyp|Asymptomatic Gallstones Without Cholecystitis
Interventions: DRUG: Lidocaine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase II Study of Intermittent Recombinant Human Interleukin-2 (rhIL-2) by Intravenous or Subcutaneous Administration in Subjects With HIV Infection on Highly Active Antiretroviral Therapy (HAART) Compared to HAART Alone
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Lamivudine|DRUG: Stavudine|DRUG: Zidovudine|DRUG: Didanosine|DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Age-related Variability of the Efficacy and Tolerability of Alternative Pituitary Suppression Regimens in ART
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: hFSH（Fostimon）|DRUG: hFSH（Fostimon）|DRUG: hFSH（Fostimon）|DRUG: hFSH（Fostimon）
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics and Safety of the Co-administration of ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 in Healthy Chinese Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: ABT-450/r/ABT-267|DRUG: ABT-333
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-Dose,ComparativeBioavailability Study ofTwo Formulations ofErlotinib150mgTabletsunderFastingConditions
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Erlotinib HCl 150 mg|DRUG: Tarceva®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect on Fenoterol Metered Dose Inhaler on the Beta-receptor Population on Lymphocytes in Patients With Bronchial Asthma
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: Fenoterol MDI|DRUG: DSCG MDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: BI 655066 (Risankizumab) Compared to Placebo and Active Comparator (Ustekinumab) in Patients With Moderate to Severe Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: risankizumab|DRUG: placebo for risankizumab|DRUG: ustekinumab|DRUG: placebo for ustekinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HPV-T in HPV-16 Positive Recurrent or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor
Interventions: BIOLOGICAL: HPV-T|DRUG: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pancreatic Endotherapy for Refractory Chronic Pancreatitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Duct Stone|Pancreatic Duct Stricture|Pancreatic Duct Dilatation
Interventions: PROCEDURE: EUS + SHAM|PROCEDURE: EUS + Pancreatic Endotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Airseal System Valve-less Trocar on the Ventilatory Parameters During Robotic-assisted Radical Cystectomy
Status: COMPLETED
Conditions: Mechanical Ventilation Pressure High
Interventions: DEVICE: Airseal Trocar|DEVICE: conventional trocar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Clareon Vivity/Vivity Toric
Status: COMPLETED
Conditions: Aphakia
Interventions: DEVICE: Clareon Vivity/Vivity Toric Extended Vision IOL|DEVICE: Clareon/Clareon Toric Aspheric IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Avastin (Bevacizumab) in Combination With XELOX in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: bevacizumab [Avastin]|DRUG: capecitabine [Xeloda]|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Therapy and Flouride Therapy in Desensibilization Hypomineralized Teeth
Status: COMPLETED
Conditions: Hypomineralization Molar Incisor
Interventions: RADIATION: Laser therapy|PROCEDURE: Fluorotherapy|COMBINATION_PRODUCT: Laser therapy and Fluorotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Efficacy and Safety of Bevacizumab, Carboplatin, Gemcitabine and Atezolizumab in Breast Cancer
Status: RECRUITING
Conditions: Metastatic Triple Negative Breast Cancer
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab|DRUG: Gemcitabine|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zanubrutinib in Participants With Active Proliferative Lupus Nephritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Lupus Nephritis
Interventions: DRUG: Zanubrutinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Opioid-free Anesthesia for Open Cardiac Surgery: A Prospective Randomized Controlled Trial
Status: COMPLETED
Conditions: Opioid Use|Heart; Surgery, Heart, Functional Disturbance as Result|Anesthesia
Interventions: DRUG: Opioid Anesthetics|DRUG: Non Opioid Analgesics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effect of Ketoconazole on Sufentanil NanoTab Pharmacokinetics
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Sufentanil NanoTab (SUF NT) 15 mcg|DRUG: Ketoconazole 400 mg, sufentanil NanoTab (SUF NT) 15 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Drug-Drug Interaction Study Between Fenofibric Acid and Efavirenz
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Efavirenz 600 mg|DRUG: Efavirenz 600 mg|DRUG: Fenofibric Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Donepezil in Female Breast Cancer Survivors With Cognitive Dysfunction
Status: COMPLETED
Conditions: Anxiety Disorder|Breast Cancer|Cognition Disorders|Depression|Fatigue|Sleep Disorders
Interventions: DRUG: donepezil hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sildenafil in US Heart Failure Patients (SilHF-US)
Status: UNKNOWN
Conditions: Heart Failure|Pulmonary Hypertension
Interventions: DRUG: Sildenafil|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenomic and Pharmacokinetic Safety and Cost-saving Analysis in Patients Treated With Fluoropyrimidines
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Capecitabine, 5-fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Icotinib and Arsenic Trioxide in Treating Non-small-cell Lung Cancer Patients With Resistance to EGFR-TKI
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Icotinib|DRUG: Arsenic trioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Donepezil on Wound Healing
Status: RECRUITING
Conditions: Wound Heal
Interventions: DRUG: Donepezil|DRUG: Placebo oral tablet|DRUG: Topical Zinc Oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Response to Clenbuterol in Humans
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Clenbuterol Oral Product|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Comparing Traditional and Gender-specific Total Knee Replacement Designs
Status: WITHDRAWN
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Zimmer LPS flex Gender Specific Implant (Total knee replacement)|DEVICE: Zimmer High Flex LPS Implant (Total knee replacement)|DEVICE: Stryker Triathlon Implant (Total knee replacement)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Improvements Through the Use of a Rapid Multiplex PCR Enteric Pathogen Detection Kit in Children With Hematochezia
Status: COMPLETED
Conditions: Diarrhea Bloody
Interventions: DEVICE: BioFire Gastrointestinal Panel FilmArray®|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sipuleucel-T and Ipilimumab for Advanced Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Castrate Resistant Prostate Cancer
Interventions: DRUG: sipuleucel-T|DRUG: ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Real-World Study to Learn More About the Order of Different Treatments and Their Effects in People With Metastatic Colorectal Cancer Receiving Their Third and Fourth Line of Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Regorafenib (Stivarga, BAY73-4506)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hemodynamic Safety of Levobupivacaine vs Bupivacaine in Patients Over 65 Years Undergoing Hip Surgery
Status: UNKNOWN
Conditions: Hip Fractures|Hemodynamic Stability
Interventions: DRUG: Levobupivacaine Hydrochloride 0.5%|DRUG: Isobaric bupivacaine 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Ivacaftor in Subjects With Cystic Fibrosis (CF) Who Have a Non-G551D CF Transmembrane Conductance Regulator (CFTR) Gating Mutation
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Ivacaftor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 23-gauge Pars Plana Vitrectomy With Silicone Oil Injectionsilicone Oil Injection With Surgical
Status: COMPLETED
Conditions: Retinal Detachment
Interventions: PROCEDURE: 23 PARS PLANA VITRECTOMY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-Site Trial of the Impact of Assistive Technology With Assistance Users and Their Caregivers
Status: UNKNOWN
Conditions: Mobility Disability|Older Adults|Community Dwelling
Interventions: DEVICE: Assistive Technology Provision and Tune-Up Intervention|DEVICE: Customary Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MK-3475 in Melanoma and NSCLC Patients With Brain Metastases
Status: COMPLETED
Conditions: Melanoma|Non-Small Cell Lung Cancer|Brain Metastases
Interventions: DRUG: MK-3475
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab Alone Versus Dose-dense Temozolomide Followed by Bevacizumab for Recurrent Glioblastoma, Phase III
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma|Recurrence|Progression
Interventions: DRUG: Temozolomide|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endobronchial Ultrasound-Guided Transbronchial Needle-Aspiration With Suction in Obtaining Samples From Patients With Suspected Nodal Metastatic Lung Cancer
Status: UNKNOWN
Conditions: Lung Carcinoma
Interventions: PROCEDURE: Bronchoscopy|PROCEDURE: Ultrasound-Guided Transbronchial Needle Aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of the Clinical Performance of 3 THERANOVA 400 Dialyzer Prototypes With a High-Flux Dialyzer in Hemodialysis Mode
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DEVICE: THERANOVA 400 dialyzer prototype AA|DEVICE: THERANOVA 400 dialyzer prototype BB|DEVICE: THERNOVA 400 dialyzer prototype CC|DEVICE: FX CorDiax 80 dialyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy and Safety of Etanercept and Methotrexate in Japanese Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Etanercept|DRUG: Etanercept|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Tocotrienol in Recurrent Ovarian Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer Recurrent
Interventions: DRUG: Bevacizumab|DIETARY_SUPPLEMENT: Tocotrienol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Targeted, Local Delivery of Drugs to Treat Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: Delayed Release 6MP or Calcitriol vs. Purinethol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Maximum Tolerated Dose of Mesenchymal Stem Cells From Umbilical Cord
Status: UNKNOWN
Conditions: Knee Osteoarthritis|Umbilical Cord Bleeding
Interventions: DRUG: mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Single Agent Selinexor Versus Physician's Choice in Participants With Previously Treated Myelofibrosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelofibrosis
Interventions: DRUG: Selinexor|OTHER: Physician's Choice Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is a Third Dose of MMRV Vaccine Beneficial for the Adult Population in Alberta?
Status: NOT_YET_RECRUITING
Conditions: Vaccination Failure|Vaccine Response Impaired
Interventions: DIAGNOSTIC_TEST: Serology for antibody levels - Baseline|DIAGNOSTIC_TEST: Serology to assess cell mediated immune (CMI) response - Baseline|DIAGNOSTIC_TEST: Serology for antibody levels - Post third dose of MMR vaccine|DIAGNOSTIC_TEST: Serology to assess CMI - Post third dose of MMR vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Child Choice With Accompanying Parent on Postoperative Delirium During Induction of Anesthesia
Status: COMPLETED
Conditions: Anxiety State|Child Behavior|Postoperative Delirium
Interventions: PROCEDURE: Selection of parent(mother or father) according to children preference|PROCEDURE: Parent (mother or father) selection according to parents' preference
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Optimizing Acute Malnutrition Management in Children Aged 6 to 59 Months in Niger (OptIMA Niger)
Status: COMPLETED
Conditions: Acute Malnutrition in Infancy (Disorder)
Interventions: DIETARY_SUPPLEMENT: Nutritional Strategy - OptiMA|DIETARY_SUPPLEMENT: Nutritional Strategy - ComPAS|OTHER: National nutritional Strategy (Niger)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zanubrutinib Combined With R-CHOP in Newly-diagnosed Intravascular Large B-cell Lymphoma
Status: RECRUITING
Conditions: Intravascular Large B-Cell Lymphoma
Interventions: DRUG: Zanubrutinib|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Epirubicin|DRUG: Vindesine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Downmodulating Monocyte Activation for HIV-1 Associated Neurocognitive Disorders (HAND)
Status: COMPLETED
Conditions: HIV Dementia
Interventions: DRUG: Atorvastatin (generic Lipitor)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Insulin Correction Factor in Post- High Intensity Exercise Hyperglycemia in Adults With Type 1 Diabetes (FIT)
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: 50% bolus insulin correction|DRUG: 100% bolus insulin correction|DRUG: 150% bolus insulin correction|OTHER: 0% bolus insulin correction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT