pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: To Investigate Effects GSK561679 on Part of the Body's System That Controls the Balance of Many of the Hormones.
Status: COMPLETED
Conditions: Depressive Disorder and Anxiety Disorders
Interventions: DRUG: metyrapone|DRUG: alprazolam|DRUG: placebo|DRUG: GSK561679
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: Investigating Hearing Aid Frequency Response Curves
Status: COMPLETED
Conditions: Hearing Loss, Sensorineural|Hearing Loss, Bilateral
Interventions: DEVICE: Hearing Aid - Standard Curve|DEVICE: Hearing Aid - Variation #1|DEVICE: Hearing Aid - Variation #2|DEVICE: Hearing Aid - Variation #3|DEVICE: Hearing Aid - Variation #4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First - In - Man Study to Assess the Safety and Feasibility of The Bashir™ Endovascular Catheter for the Treatment of Acute Pulmonary Embolism
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: DRUG: r-tPA|DEVICE: The Bashir™ Endovascular Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing a Pantoprazole Formulation to the Currently Marketed Tablet for GERD and Erosive Esophagitis
Status: COMPLETED
Conditions: Gastroesophageal Reflux|Esophagitis
Interventions: DRUG: Pantoprazole for approximately 9 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fucoidan Assisted Eradication of Helicobacter Pylori
Status: RECRUITING
Conditions: Helicobacter Pylori Infection|Intestinal Bacteria Flora Disturbance
Interventions: BIOLOGICAL: Amoxicillin combined with vonoprazan and fucoidan|OTHER: Amoxicillin combined with vonoprazan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotic Lactobacilli on Vaginal Flora of Pregnant Women at High Risk for Preterm Delivery
Status: WITHDRAWN
Conditions: Premature Birth|Bacterial Vaginosis
Interventions: DRUG: Lactobacilli GR-1 and RC-14
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pivotal Study to Evaluate the Efficacy of Lorundrostat in Subjects With Uncontrolled Hypertension on a Standardized Antihypertensive Medication Regimen
Status: RECRUITING
Conditions: Hypertension
Interventions: DRUG: Placebo|DRUG: lorundrostat Dose 1|DRUG: lorundrostat Dose 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Thromboelastometry-identified Haemostatic Changes in Isolated Traumatic Brain Injury
Status: COMPLETED
Conditions: Coagulation Disorder|Brain Injuries, Traumatic|Bleeding
Interventions: OTHER: Thromboelastometry-guided haemostatic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Atorvastatin + Perindopril Fixed-Dose Combination S05167 in Adult Patients With Arterial Hypertension and Dyslipidemia
Status: TERMINATED
Conditions: Dyslipidemias|Hypertension
Interventions: DRUG: Atorvastatin/Perindopril|DRUG: Atorvastatin|DRUG: Perindopril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Insulin Regulation of Lipolysis and Lipolysis Proteins
Status: RECRUITING
Conditions: Obesity
Interventions: BEHAVIORAL: Immediate weight loss|DRUG: Pioglitazone|BEHAVIORAL: Deferred weight loss|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Optical CoherenCe Tomography-gUided Coronary Intervention in Patients With Complex lesIons: a Randomized Controlled Trial (OCCUPI Trial)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: OCT-guided PCI|DEVICE: Angiography-guided PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prognostic Value of Biochemical Markers in Cerebrospinal Fluid for Functional Outcome of Spinal Cord Injured Patients
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: OTHER: Lumbar puncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Long-term Safety and Efficacy of LBEC0101 in Subjects With Active RA Despite Methotrexate (MTX)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: LBEC0101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LTOT in COPD Patients With Moderate Chronic Hypoxemia and Chronic Heart Failure
Status: UNKNOWN
Conditions: Lung Diseases, Obstructive|Chronic Heart Failure|Chronic Hypoxemia
Interventions: OTHER: LTOT (oxygen therapy)|OTHER: Pharmacological therapy of COPD and CHF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lenvatinib as an Adjuvant Therapy for Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma (HCC)
Interventions: DRUG: Lenvima 4 mg Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Levcromakalim Infusion on the Cranial Arteries Over Several Hours Using a High Resolution MRA Technique in a Randomized, Double-blind Placebo-controlled Design in Healthy Volunteers.
Status: COMPLETED
Conditions: Dilatation of Cranial Arteries; MMA, STA and MCA|Headache
Interventions: DRUG: Levcromakalim|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Azithromycin Combination Therapy for Malaria
Status: COMPLETED
Conditions: Plasmodium Falciparum Malaria
Interventions: DRUG: Artesunate|DRUG: Azithromycin|DRUG: Quinine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Refractory Ascites
Status: RECRUITING
Conditions: Cirrhosis, Liver|Acute-On-Chronic Liver Failure|Refractory Ascites|Ascites|Acute Kidney Injury
Interventions: DIAGNOSTIC_TEST: Echocardiographic assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vısual Arts Group Therapy Based On Watson's Human Care Model In Indıvıduals Wıth Schızophrenıa
Status: COMPLETED
Conditions: Schizophrenia|Art Therapy|Social Support
Interventions: OTHER: Vısual Arts Group Therapy Based On Watson's Human Care Model|OTHER: Ongoing treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Renal and Systemic Effects of NCX4016 in Patients With Type 2 Diabetes and Early Nephropathy
Status: TERMINATED
Conditions: Type 2 Diabetes|Early Nephropathy
Interventions: DRUG: nitroaspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Secretin Infusion to Prevent Pancreatic Leaks Following Pancreatic Resection
Status: COMPLETED
Conditions: Injury of Body of Pancreas
Interventions: DRUG: Secretin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Glutamatergic Function in the Pathophysiology of Treatment-resistant Schizophrenia
Status: RECRUITING
Conditions: Treatment-resistant Schizophrenia|Treatment-responsive Schizophrenia|Healthy Controls
Interventions: DRUG: Riluzole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: FLUAD vs. FLUZONE HD Influenza Vaccine in Residents of Long Term Care
Status: COMPLETED
Conditions: Flu
Interventions: DRUG: Fluad Vaccine|DRUG: Fluzone HD Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: I Kua na'u Advance Care Planning for Native Hawaiian Elders
Status: ENROLLING_BY_INVITATION
Conditions: Advance Care Planning
Interventions: BEHAVIORAL: I kua na'u "Let Me Carry Out Your Last Wishes"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of the Crestal Bone Loss Around Bone Level Versus Tissue Level Implants in Non-compliant Patients With Healthy or Reduced Periodontium After 5-8 Years in Function
Status: UNKNOWN
Conditions: Periimplantitis|Marginal Bone Loss
Interventions: RADIATION: Periapical radiographs
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Seprapack Sinus Dressing Versus No Dressing in the Prevention of Intranasal Adhesions Following Sinus Surgery
Status: TERMINATED
Conditions: Chronic Sinusitis
Interventions: DEVICE: Seprapack Sinus Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Eplerenone and Extracellular Adenosine Formation
Status: COMPLETED
Conditions: Pharmacodynamics
Interventions: DRUG: Eplerenone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of APL180 on Endothelial Function in Familial Hypercholesterolemia Patients
Status: WITHDRAWN
Conditions: Familial Hypercholesterolemia
Interventions: DRUG: APL180|DRUG: APL180|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Study of Apelin-APJ System on Pulmonary Hypertension Patients and Healthy Subjects
Status: COMPLETED
Conditions: Idiopathic Pulmonary Arterial Hypertension
Interventions: DRUG: (Pyr1)apelin-13|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Case-control Study of Mesh-infection After a Size Tailored Hernia Repair With C-Qur V-Patch
Status: UNKNOWN
Conditions: Ventral Hernia|Umbilical Hernia|Epigastric Hernia|Trocar-site Hernia
Interventions: PROCEDURE: primary ventral hernia repair with mesh
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Immunogenicity of Prime-Boost Vesicular Stomatitis Virus (VSV) Ebola Vaccine in Healthy Adults (V920-002)
Status: COMPLETED
Conditions: Ebola Viruses
Interventions: OTHER: Placebo|BIOLOGICAL: V920
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of an Anti-TLR4 mAb in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: NI-0101|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Facial Lipoatrophy Trial: Immediate Versus Deferred Injections of Poly-L-Lactic Acid for HIV Facial Lipoatrophy
Status: TERMINATED
Conditions: HIV-Associated Lipodystrophy|HIV Infections
Interventions: DEVICE: poly-L-lactic acid|DEVICE: poly-L-lactic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: University of Wisconsin Solution Versus New Parathyroid Transport Solution for Parathyroid Allotransplantation
Status: UNKNOWN
Conditions: Parathyroid Allotransplantation
Interventions: COMBINATION_PRODUCT: NPT and UW Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reducing Perinatal Anal Incontinence Through Early Pelvic Floor Muscle Training: a Prospective Pilot Study
Status: COMPLETED
Conditions: Perinatal and Postpartum Anal Incontinence
Interventions: OTHER: Pelvic floor training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Neuromuscular Electrostimulation in Multiple Sclerosis People With Dysphagia
Status: RECRUITING
Conditions: Deglutition Disorders|Multiple Sclerosis
Interventions: DEVICE: Experimental: traditional dysphagia therapy plus Neuromuscular electrostimulation|DEVICE: Sham Comparator: Traditional dysphagia therapy plus sham Neuromuscular electrostimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Cranial Electrotherapy Stimulation in Burned Patients
Status: COMPLETED
Conditions: Post Traumatic Stress Disorders|Burns
Interventions: DEVICE: Alpha Stim 100 (Cranial Electrotherapy Stimulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Non-invasive Vagus Nerve Stimulation in the Treatment of Headache in Subarachnoid Hemorrhage
Status: COMPLETED
Conditions: Subarachnoid Hemorrhage, Aneurysmal
Interventions: DEVICE: gammaCore
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ProSPective Evaluation of Non-contrast sINe spiN Flat-dEtectoR CT for the Detection of Intracranial hemorrhageS
Status: RECRUITING
Conditions: Stroke
Interventions: DIAGNOSTIC_TEST: Non-contrast cranial MDCT head scan|DIAGNOSTIC_TEST: Non-contrast syngo DynaCT Sine Spin head scan and application software
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Trial To Evaluate The Efficacy of Magnetic Resonant Therapy in Autism
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DEVICE: Magnetic Resonance Therapy (MRT)-Active|DEVICE: Magnetic Resonance Therapy (MRT)-Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Impact of Omega-3 Fatty Acid Supplementation (Soloways™) on Lipid Profiles in Adults With PPARG Polymorphisms
Status: COMPLETED
Conditions: LDL Hyperlipoproteinemia|Low-Density-Lipoprotein-Type [LDL] Hyperlipoproteinemia|Triglyceride Storage Type I or II Disease
Interventions: DIETARY_SUPPLEMENT: omega-3 fatty acids|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Lipolytic Effects of GH in Hypopituitary Patients in Vivo
Status: COMPLETED
Conditions: Hypopituitarism|Insulin Resistance|Endocrine System Diseases|Glucose Metabolism Disorders|Metabolic Diseases|Pituitary Diseases|Brain Diseases
Interventions: DRUG: Acipimox|DRUG: Placebo|DRUG: GH substitution|OTHER: GH pause
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Strategy for Maintenance of HIV Suppression With Once Daily Integrate Inhibitor+Darunavir/Ritonavir in Children
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: DTG +DRV/r|DRUG: SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Acute Lymphoblastic Leukemia or Aggressive Lymphoma With Relapse in Central Nervous System With Depocyt
Status: COMPLETED
Conditions: Adult Acute Lymphocytic Leukemia
Interventions: DRUG: Depocyt|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patiromer Utility as an Adjunct Treatment in Patients Needing Urgent Hyperkalemia Management
Status: TERMINATED
Conditions: Hyperkalemia
Interventions: DRUG: Patiromer Powder for Oral Suspension [Veltassa]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitis
Status: COMPLETED
Conditions: Sinusitis
Interventions: DRUG: Doxycycline|DRUG: Azithromycin|DRUG: Augmentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of LE-DT to Treat Metastatic Castrate Resistant Prostate Cancer
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: DRUG: Liposome Entrapped Docetaxel (LE-DT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Between Two Follow up Regimens With Different Test Intensity in Endometrial Cancer Treated Patients
Status: UNKNOWN
Conditions: Endometrial Cancer
Interventions: PROCEDURE: Intensive/Low-Risk follow up (IA G1; IA G2)|PROCEDURE: Intensive/High-Risk follow up (≥ IA G3)|PROCEDURE: Minimalist/Low-Risk follow up (IA G1; IA G2)|PROCEDURE: Minimalist/High-Risk follow up (≥ IA G3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Investigation of Supra Fiber in the Treatment of Adults With Constipation
Status: COMPLETED
Conditions: Constipation
Interventions: DIETARY_SUPPLEMENT: Supra Fiber|DIETARY_SUPPLEMENT: Psyllium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Pamidronate With Zoledronic Acid for Transplant Related Bone Loss Prevention
Status: COMPLETED
Conditions: Osteopenia|Complications of Heart-lung Transplant|Other Complications of Lung Transplant
Interventions: DRUG: zoledronic acid vs pamidronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMPACT OF BREATH CONTROL AND RETENTION ON PATIENT STRESS. E.S IN MEDICALLY ASSISTED REPRODUCTION BREATH HOLD TO BREATH BETTER PROGRAM
Status: NOT_YET_RECRUITING
Conditions: Reproductive Disorder
Interventions: OTHER: Breathing Control and Retention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Autonomic Function and Cardiovascular Risk in Restless Legs Syndrome
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: Pramipexole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Treatment of Impulsive Aggression in Subjects With ADHD in Conjunction With Standard ADHD Treatment (CHIME 1)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: DRUG: SPN-810 (18 mg)|DRUG: SPN-810 (36 mg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Tranilast on Pharmacokinetics of Methotrexate (MTX) in Patients With Rheumatoid Arthritis (RA)
Status: WITHDRAWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tranilast|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Fluconazole in Hypercalcicuric Patients With Increased 1.25(OH) 2D Levels
Status: COMPLETED
Conditions: Nephrolithiasis|Nephrocalcinosis|Hypercalciuria
Interventions: DRUG: Fluconazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient-derived Organoid Drug Sensitivity Guided Treatment for Drug-resistant Recurrent Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: OTHER: Chemotherapy and targeted-therapy guided by organoid drug sensitivity test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving HIV and Alcohol-Related Outcomes Among HIV+ Persons in Clinic Settings
Status: COMPLETED
Conditions: HIV|Alcohol Use|Medication Adherence
Interventions: BEHAVIORAL: Immediate PLUS intervention|BEHAVIORAL: Wait-list PLUS intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Do Superfast Broadband and Tailored Interventions Improve Use of E-health and Reduce Health Related Travel?
Status: UNKNOWN
Conditions: eHealth
Interventions: BEHAVIORAL: Tailored Leaflet|BEHAVIORAL: GP visit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Exercise on Glymphatic Functioning and Neurobehavioral Correlates in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease and Parkinsonism|Glymphatic System
Interventions: BEHAVIORAL: Exercise--Rock Steady Boxing class
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dabrafenib Plus Trametinib vs Vemurafenib Alone in Unresectable or Metastatic BRAF V600E/K Cutaneous Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Dabrafenib|DRUG: Vemurafenib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Actions For Collaborative Community Engaged Strategies for HPV
Status: RECRUITING
Conditions: HPV|Stigma
Interventions: BEHAVIORAL: Heroes for Her|BEHAVIORAL: The Reach Initiative|BEHAVIORAL: W.H.I.T.E project|BEHAVIORAL: Project Shield|BEHAVIORAL: Project SHADE|BEHAVIORAL: Operation Reach Her (ORH) program|BEHAVIORAL: Project Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: COVID 19 ANTOBODIES IN PREGNANT WOMEN AND THEIR CONNECTION TO BETA CELL FUNCTION IN THE FETUS
Status: UNKNOWN
Conditions: Generation of Anti COVID-19 Antibodies in a Fetus, Whose Mother Was Exposed to COVID or Was Vaccinated During Pregnancy
Interventions: OTHER: no intervention, observation only
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of [18F]MK-9470 as a Brain Tracer of Cannabinoid-1 Receptor in Parkinson's Disease and Healthy Subjects
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: [18F]MK-9470
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Venous Blood Flow Velocity: Electrical Foot Stimulation Compared to Intermittent Pneumatic Compression of the Foot
Status: COMPLETED
Conditions: Deep Vein Thrombosis|Pulmonary Embolism
Interventions: DEVICE: The Focus™ Neuromuscular Stimulation System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safe Laparoscopic Access in Patients With Previous Abdominal and Pelvic Surgery
Status: COMPLETED
Conditions: Laparoscopic Surgery
Interventions: PROCEDURE: new laparoscopic access technique for group a|PROCEDURE: Hasson's technique for laparoscopic access in group b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity and Safety of ADACEL™ as Fifth Dose in Taiwan
Status: COMPLETED
Conditions: Diphtheria|Tetanus|Pertussis
Interventions: BIOLOGICAL: Diphteria, tetanus, and Acellular Pertussis vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare the Pharmacokinetics and Safety of Optivate® and Haemate P® in Patients With Von Willebrand Disease.
Status: COMPLETED
Conditions: vonWillebrand's Disease
Interventions: BIOLOGICAL: Optivate® (Human Coagulation Factor VIII)|BIOLOGICAL: Haemate P® (Human Coagulation Factor VIII)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of a Social Media-based Health Education Program on Postnatal Care (PNC) Knowledge Among Pregnant Women Using Smartphones in Dhulikhel Hospital
Status: COMPLETED
Conditions: Unrecognized Condition
Interventions: OTHER: Social media-based Health education program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Priority to Cryopreservation Strategy (PCS) in IVF-ICSI Cycles
Status: RECRUITING
Conditions: Infertility|IVF|ICSI|Cryopreservation
Interventions: PROCEDURE: Priority to freeze|PROCEDURE: Fresh embryo transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Feasibility and Safety of UCD19 Chimeric Antigen Receptor (CAR) T Cells in Adult Subjects With Relapsed/Refractory (R/R) B-Cell Non-Hodgkin's Lymphoma (B-NHL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Hodgkin Lymphoma
Interventions: BIOLOGICAL: UCD19 CAR T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aerobic Exercise Versus Whole-Body Vibration on Fatigue, Functional Capacity, Quality of Life in Systemic Lupus
Status: ENROLLING_BY_INVITATION
Conditions: Systemic|Lupus
Interventions: OTHER: Group A (GA)(Aerobic exercise group)|OTHER: Group B (GB) (Whole-body vibration (WBV) group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability of E2007 in Levodopa Treated Parkinson's Disease Patients With Motor Fluctuations
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: 2 mg perampanel|DRUG: 4 mg perampanel|DRUG: placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of Ad5-nCoV and Ad5-nCoV-IH in CoronaVac Immunized Children and Adolescents
Status: TERMINATED
Conditions: COVID-19
Interventions: BIOLOGICAL: Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector)|BIOLOGICAL: Recombinant COVID-19 vaccine (adenovirus type 5 vector) for Inhalation (Ad5-nCoV-IH)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Oral Progesterone for Prevention of Miscarriage in Threatened Abortion
Status: COMPLETED
Conditions: Threatened Abortion
Interventions: DRUG: Dydrogesterone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A UK Registry for Metabolic and Bariatric Endoscopic Interventions
Status: RECRUITING
Conditions: Obesity|Diabetes Mellitus, Type 2
Interventions: DEVICE: Endoscopic gastric suturing|DEVICE: Endoscopic gastric plication|DEVICE: Revisional gastroplasty|DEVICE: Transoral outlet reduction endoscopy (TORe)|DEVICE: Duodenal mucosal resurfacing (DMR)|DEVICE: Intragastric balloon(s)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety of Dual Blockage of Rennin-angiotensin System in Patients With Advanced Renal Insufficiency
Status: TERMINATED
Conditions: Renal Insufficiency, Chronic
Interventions: DRUG: Benazepril|DRUG: Losartan|DRUG: Benazepril+Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CHIO3 Trial: CHemotherapy Combined With Immune Checkpoint Inhibitor for Operable Stage IIIA/B Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage IIIA Non-small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer
Interventions: DRUG: Durvalumab|PROCEDURE: Surgery|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Followed by Bone Marrow or Stem Cell Transplantation in Treating Patients With Relapsed or Refractory Germ Cell Tumors
Status: COMPLETED
Conditions: Extragonadal Germ Cell Tumor|Ovarian Cancer|Testicular Germ Cell Tumor
Interventions: DRUG: carboplatin|DRUG: etoposide|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Diagnosis and Treatment of Sleep Apnea in Cerebrovascular Disease
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Stroke|Transient Ischemic Attack|Hypertension
Interventions: PROCEDURE: CPAP Therapy for Newly Diagnosed Obstructive Sleep Apnea (OSA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The TESLA Trial: Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: PROCEDURE: Intra-arterial Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Testing in Underserved and Vulnerable Populations
Status: TERMINATED
Conditions: Heart Failure|Coronary Artery Disease|Cancer|Chronic Kidney Diseases|COPD|Obesity|Sickle Cell Disease|Diabetes Mellitus, Type 2
Interventions: OTHER: Community outreach method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Long Term Extension Study to Assess the Safety and Efficacy of Filgotinib in Adults With Rheumatoid Arthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Filgotinib|DRUG: Placebo to match filgotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRIMARA: A Prospective Descriptive Observational Study to Review Mimpara (Cinacalcet) Use in Patients With Primary Hyperparathyroidism in Clinical Practice
Status: COMPLETED
Conditions: Hyperparathyroidism, Primary
Interventions: DRUG: Cinacalcet
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lenalidomide, Dexamethasone and Cyclophosphamide in Amyloidosis (AL)
Status: COMPLETED
Conditions: Amyloidosis
Interventions: DRUG: Lenalidomide, Dexamethasone and Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cemented Versus Uncemented Stems in Total Hip Arthroplasty in Patients With Femoral Neck Fractures
Status: COMPLETED
Conditions: Femoral Neck Fractures
Interventions: PROCEDURE: Total Hip Arthroplasty|DEVICE: Cemented Lubinus SPII stem (control arm)|DEVICE: Uncemented HA Coated Corail stem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Real-life Study of the Use of Cabotegravir Plus Rilpivirine Long-acting in ART-experienced Pre-treated People With HIV
Status: ACTIVE_NOT_RECRUITING
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: Cabotegravir Injectable Product|DRUG: Rilpivirine Injectable Product
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility Study and Preliminary Application Study on Iris OCTA
Status: UNKNOWN
Conditions: Conjunctivitis|Glaucoma|Myopia|Diabetic Retinopathy|Retinal Detachment|Retinal Neovascularization, Unspecified|Uveitis
Interventions: DIAGNOSTIC_TEST: OCTA (ZEISS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A 6-Month Extension Study To The B2061032 Study To Evaluate The Safety, Tolerability, And Efficacy Of DVS SR In The Treatment Of Child And Adolescent Outpatients With MDD
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: DVS SR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Add-On Ramelteon in Bipolar I Disorder With Clinically Significant Sleep Disturbance
Status: TERMINATED
Conditions: Insomnia|Bipolar Disorder
Interventions: DRUG: Ramelteon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multiple Ascending Dose Study of Daclatasvir (BMS-790052) in Hepatitis C Virus Genotype 1 Infected Subjects
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Daclatasvir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise as a Tool for Studying the Mechanisms and Applicability of Glycemic Variability
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: OTHER: Aerobic Exercises|OTHER: Eccentric Exercise|DEVICE: Continuous glucose monitoring system (Guardian, Medtronic, Northridge, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Eye Movements and Visuo-spatial Perception
Status: COMPLETED
Conditions: Cerebellum Disease
Interventions: BEHAVIORAL: Forward adaptation of reactive saccades|BEHAVIORAL: Backward adaptation of reactive saccades|BEHAVIORAL: Execution of reactive saccades|BEHAVIORAL: Generation of reactive saccades
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trochanteric Bursal Repair After a Total Hip Replacement - Are There Benefits During the First 90 Days
Status: COMPLETED
Conditions: Bursa; Tuberculous|Hip Bursitis|Deep Gluteal Syndrome|Hip Disease
Interventions: PROCEDURE: Trochanteric bursa repaired|PROCEDURE: Trochanteric bursa unrepaired
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)
Status: RECRUITING
Conditions: Emphysema|HIV
Interventions: DRUG: Doxycycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coached or Non-Coached Weight Loss Intervention
Status: COMPLETED
Conditions: Obesity|Behavior, Health|Behavior, Eating|Weight Loss|Overweight and Obesity|Self Efficacy
Interventions: BEHAVIORAL: Noom Healthy Weight; mobile behavior change program for weight loss with 1:1 coaching|BEHAVIORAL: Noom Healthy Weight; mobile behavior change program for weight loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Antithymocyte Globulin and Cyclosporine in Treating Patients With Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: ATG + CSA|BEHAVIORAL: Supportive care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resiliency Training for Adults With Neurofibromatosis Via Live Videoconferencing
Status: UNKNOWN
Conditions: Neurofibromatoses|Neurofibromatosis 1|Neurofibromatosis 2|Schwannomatosis
Interventions: BEHAVIORAL: Stress and Symptom Management Program 1|BEHAVIORAL: Stress and Symptom Management Program 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: GMMG-HD10 / DSMM-XX / 64007957MMY2003, MajesTEC-5
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Teclistamab (Tec)|DRUG: Daratumumab|DRUG: Dexamethasone|DRUG: Lenalidomide|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prior Axitinib as a Determinant of Outcome of Renal Surgery
Status: UNKNOWN
Conditions: Clear Cell Renal Cell Carcinoma
Interventions: DRUG: Axitinib Oral Tablet [Inlyta]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy & Safety Trial of Intravitreal Injections Combined With PRP for CSME Secondary to Diabetes Mellitus (DAVE)
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: 0.3 mg ranibizumab|PROCEDURE: Targeted Pan Retinal Photocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis at Risk for Pulmonary Hypertension
Status: TERMINATED
Conditions: Pulmonary Fibrosis|Pulmonary Hypertension
Interventions: COMBINATION_PRODUCT: INOpulse®|COMBINATION_PRODUCT: Placebo|COMBINATION_PRODUCT: Open Label Extension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Application of Intra-operative Prophylactic Antibiotics/Antiseptics in Chinese Breast Reconstruction Patients
Status: UNKNOWN
Conditions: Breast Neoplasms
Interventions: DRUG: Cefazolin/clindamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Pilot Text Messaging Intervention to Reduce Smoking in Office-based Buprenorphine and Inpatient Detoxification Patients
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: OTHER: Treatment As Usual (TAU)|DRUG: Nicotine Replacement Therapies|BEHAVIORAL: Text Message Intervention (TMI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Recombinant Protein Vaccine Formulations Against COVID-19 in Healthy Adults 18 Years of Age and Older
Status: COMPLETED
Conditions: COVID-19 (Healthy Volunteers)
Interventions: BIOLOGICAL: CoV2 preS dTM-AF03 (low-dose)|BIOLOGICAL: CoV2 preS dTM-AF03 (high-dose)|BIOLOGICAL: CoV2 preS dTM-AS03 (low-dose)|BIOLOGICAL: CoV2 preS dTM-AS03 (high-dose)|BIOLOGICAL: CoV2 preS dTM (high-dose) without adjuvant|BIOLOGICAL: Placebo (0.9% normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating The Safety Of AAB-003 (PF-05236812) In Subjects With Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: AAB-003 (PF-05236812)|DRUG: AAB-003 (PF-05236812)|DRUG: AAB-003 (PF-05236812)|DRUG: AAB-003 (PF-05236812)|DRUG: AAB-003 (PF-05236812)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study Evaluate the Efficacy and Safety of BAT1406 and Humira
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: DRUG: BAT1406|DRUG: Humira
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mesothelin-targeted CAR-T Cells as a Neo-adjuvant Treatment in Patients With Resectable Pancreatic Cancers: a Feasibility Study
Status: WITHDRAWN
Conditions: Pancreatic Cancer
Interventions: OTHER: MSLN CART
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACHIEVE - Efficacy and Effectiveness of Adoptive Cellular tHerapy wIth Ex-Vivo Expanded Allogeneic γδ T-lymphocytes (TCB008) for Patients With Refractory or Relapsed Acute Myeloid Leukaemia (AML)
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: TCB008
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketogenic Diet for Status Epilepticus in Children Post Cessation of Convulsive Status Epilepticus
Status: RECRUITING
Conditions: Status Epilepticus|Ketogenic Dieting
Interventions: DIETARY_SUPPLEMENT: Ketogenic Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MCARH109 and MCARH125 in People With Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma|Refractory Multiple Myeloma|Relapse Multiple Myeloma
Interventions: BIOLOGICAL: MCARH125|BIOLOGICAL: MCARH109
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Second International Inter-Group Study for Classical Hodgkin Lymphoma in Children and Adolescents
Status: ACTIVE_NOT_RECRUITING
Conditions: Classical Hodgkin Lymphoma
Interventions: DRUG: cyclophosphamide, vincristine, prednisone, dacarbazine|DRUG: cyclo, vcr, pred, dacarb,etop and doxo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correlation of Serum CA19-9 Levels With Levels in Saliva and Urine of Patients With Ductal Adenocarcinoma of the Pancreas
Status: UNKNOWN
Conditions: Carcinoma, Pancreatic Ductal
Interventions: OTHER: samples of blood, saliva and urine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ultrasound Assessment of the Anatomic Landmarks for Spinal Anesthesia in Patients With Hip Fracture
Status: COMPLETED
Conditions: Hip Fractures
Interventions: DIAGNOSTIC_TEST: Noninvasive ultrasound assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Eudaimonia and Sleep: Effects of a Mindfulness Intervention in Caregivers of People With Dementia
Status: TERMINATED
Conditions: Caregivers|Burnout|Sleep
Interventions: BEHAVIORAL: Mindfulness Training|BEHAVIORAL: Reappraisal Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Vividtrac™ and Other Videolaryngoscopes in Clinical Practice
Status: UNKNOWN
Conditions: Intubation;Difficult
Interventions: DEVICE: Direct laryngoscopy|DEVICE: Vividtrac videolaryngoscope|DEVICE: KingVision videolaryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 4-aminopyridine Treatment for Nerve Injury From Radical Retro-Pubic Prostatectomy
Status: WITHDRAWN
Conditions: Prostate Disease
Interventions: DRUG: 4-aminopyridine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Cognitive Behavioral Therapy on Chronic Low Back Pain With Sensitization
Status: COMPLETED
Conditions: Chronic Low Back Pain|Central Sensitisation
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy|OTHER: Strengthening exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetic Characteristics of hzVSF-v13 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: hzVSF-v13|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT