pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Reletex Versus Standard of Care Therapy for Post-Operative Nausea Control in Patients Undergoing Foregut Surgery
Status: COMPLETED
Conditions: Nausea and Vomiting Post-foregut Surgery
Interventions: DEVICE: Reletex|DRUG: IV ondansetron 4 mg q 6 hours for a total of 4 doses|DRUG: IV promethazine 25 mg q 6 hours prn|DRUG: Elixir promethazine 25 mg q 6 hours prn after discharge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Prospective, Multi-Center, Pivotal Study to Evaluate the Safety and Effectiveness of the NovaCross™ Micro-catheter in Facilitating Crossing Chronic Total Occlusion (CTO) Coronary Lesions
Status: COMPLETED
Conditions: Chronic Total Occlusion of Coronary Artery
Interventions: DEVICE: NovaCross
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Pharmacokinetic Drug Interaction Between Metformin Hydrochloride and Rosuvastatin Calcium
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Glucophage SR tablet 750 mg, Crestor tablet 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Instrument-assisted Soft Tissue Mobilization (IASTM) on Pain and Disability in Individuals With Non-specific Chronic Neck Pain.
Status: UNKNOWN
Conditions: Neck Pain|Myofascial Pain Syndrome
Interventions: OTHER: Instrument Assisted Soft Tissue Mobilization|OTHER: Manual Myofascial Release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compression Gloves for Distal Radius Fracture
Status: COMPLETED
Conditions: Distal Radius Fractures|Fracture of Lower End of Radius|Colles' Fracture|Smith's Fracture
Interventions: DEVICE: Made-to-Measure Compression Gloves|OTHER: Routine follow up and treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketogenic Diet for New-Onset Absence Epilepsy
Status: RECRUITING
Conditions: Absence Epilepsy|Ketogenic Dieting|Epilepsy, Absence
Interventions: OTHER: Modified Atkins Diet|DRUG: Absence epilepsy medications
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in Healthy Volunteers to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CS0159
Status: COMPLETED
Conditions: Primary Sclerosing Cholangitis (PSC)
Interventions: DRUG: CS0159
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Sertindole on Sensory Gating and Cognition in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Sertindole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The 24 Hour Effects of Remedial Exercises With and Without Compression Therapy on Breast Cancer-related Lymphedema
Status: COMPLETED
Conditions: Lymphedema, Breast Cancer
Interventions: OTHER: Remedial exercise|OTHER: Compression bandage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Adjunctive Use of Melatonin Therapy in the Treatment of Obese Periodontitis Patients (Clinical and Immunological Study).
Status: UNKNOWN
Conditions: Periodontal Diseases
Interventions: DRUG: Melatonin 5Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Indinavir Plus Zidovudine Plus Lamivudine in HIV-Infected Patients With No Symptoms of Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Lamivudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Modified Cross Body Stretch Verses Modified Sleeper Stretch in Basketball Players for Posterior Capsule Tightness
Status: COMPLETED
Conditions: Shoulder Capsulitis
Interventions: OTHER: Modified cross body stretch|OTHER: Modified sleeper stretch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-dose Intra-arterial Bevacizumab for Edema and Radiation Necrosis Therapeutic Intervention (LIBERTI)
Status: COMPLETED
Conditions: Radiation Necrosis
Interventions: DRUG: 25% Mannitol|DRUG: Low-dose Intra-arterial Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Colchicine to Treat and Prevent Recurrent Pericarditis After Failure of Conventional Treatment.
Status: COMPLETED
Conditions: Pericarditis|Recurrence
Interventions: DRUG: Colchicine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Takayasu Arteritis Clinical Trial in China
Status: UNKNOWN
Conditions: Takayasu Arteritis
Interventions: DRUG: Leflunomide 10mg Tab|DRUG: Prednisone Acetate|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Predictors and Outcomes of In-hospital HFpEF in AMI Patients
Status: UNKNOWN
Conditions: Acute Myocardial Infarction|Heart Failure With Preserved Ejection Fraction|Predictor|Prognosis
Interventions: COMBINATION_PRODUCT: clinical characteristics, previous history, laboratory bio-markers, echocardiographic measurements, angiographic findings,clinical outcomes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Understanding the Role of Dietary Fatty Acids on Liver Fat Metabolism in Humans
Status: COMPLETED
Conditions: NAFLD
Interventions: DIETARY_SUPPLEMENT: Dietary supplement: fatty acid|DIETARY_SUPPLEMENT: Dietary supplement: fatty acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: S1106 Rituximab With Combination Chemotherapy or Bendamustine Hydrochloride Followed by Consolidation Chemotherapy and Stem Cell Transplantation in Older Patients With Previously Untreated Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: bendamustine hydrochloride|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: leucovorin calcium|DRUG: methotrexate|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Anti-CD19 Universal CAR-T Cells for r/r CD19+ B-ALL
Status: RECRUITING
Conditions: B-cell Acute Lymphoblastic Leukemia|B-ALL
Interventions: BIOLOGICAL: UCAR-T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of Single Rising Doses of BIIB 722 CL and HPβCD in Young Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIIB 722 CL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: PRO 140 by IV Administration in Adults With HIV-1 Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: PRO 140|DRUG: PRO 140|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise Therapy After Pulmonary Thromboendarterectomy or Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension
Status: WITHDRAWN
Conditions: Chronic Thromboembolic Pulmonary Hypertension
Interventions: BEHAVIORAL: Home exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Tests for Various Prism Configurations for Visual Field Loss
Status: RECRUITING
Conditions: Hemianopia, Homonymous|Tunnel Vision|Visual Field Defect, Peripheral|Visual Field Constriction Bilateral|Visual Field Defect Homonymous Bilateral
Interventions: DEVICE: High power prisms
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Esophagectomy for Patients With Esophageal Cancer and Cervical Lymph Node Metastases
Status: COMPLETED
Conditions: Cancer|Squamous Cell Carcinoma|Adenocarcinoma|Malignancy
Interventions: PROCEDURE: esophagectomy with three-field lymphnode dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Combination of Daratumumab and Velcade (Bortezomib) Melphalan-Prednisone (DVMP) Compared to Velcade Melphalan-Prednisone (VMP) in Participants With Previously Untreated Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Velcade|DRUG: Melphalan|DRUG: Prednisone|DRUG: Daratumumab IV|DRUG: Dexamethasone|DRUG: Daratumumab SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myeloid-Derived Suppressor Cells and Checkpoint Immune Regulators' Expression in Allogeneic SCT Using FluBuATG
Status: COMPLETED
Conditions: Leukemia, Lymphoid|Leukemia, Myeloid|Myelodysplastic Syndromes|Myelofibrosis|Lymphoma, Malignant|Multiple Myeloma|Waldenstrom Macroglobulinemia
Interventions: DRUG: Fludarabine|DRUG: Busulfan|BIOLOGICAL: Rabbit ATG|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intramuscular CodaVax-H1N1 in Healthy Adults
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: CODA-VAX H1N1|BIOLOGICAL: Flucelvax Quad|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pulmonary Echography and BNP Value Pre- and Post- Elective Cesarean Section in Spinal Anesthesia
Status: COMPLETED
Conditions: Pregnancy Related
Interventions: DIAGNOSTIC_TEST: B-Type natriuretic peptide (BNP) serum values|DEVICE: Pulmonary echography|OTHER: urine collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Targeted Pediatric High-Grade Glioma Therapy
Status: NOT_YET_RECRUITING
Conditions: High Grade Glioma|Diffuse Intrinsic Pontine Glioma|Anaplastic Astrocytoma|Glioblastoma|Glioblastoma Multiforme|Diffuse Midline Glioma, H3 K27M-Mutant|Metastatic Brain Tumor|WHO Grade III Glioma|WHO Grade IV Glioma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SystemCHANGE: An Intervention for Medication Change in Adult Kidney Transplant Patients
Status: UNKNOWN
Conditions: Kidney Disease
Interventions: BEHAVIORAL: SystemCHANGE|BEHAVIORAL: Patient-education attention control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Exenatide Taken Before Lunch and Dinner With Before Breakfast and Dinner in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: exenatide|DRUG: exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Korean Manupuncture on Pain in Women With Endometriosis: a Parallel-group Randomized Controlled Trial
Status: RECRUITING
Conditions: Endometriosis|Pain
Interventions: OTHER: Korean manupuncture|OTHER: Placebo session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of RO4917838 (Bitopertin) in Patients With Acute Exacerbation of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: bitopertin [RO4917838]|DRUG: bitopertin [RO4917838]|DRUG: olanzapine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Meloxicam 15 mg Tablets Under Non-Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Meloxicam 15 mg Tablets|DRUG: Mobic® 15 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Infrahepatic Inferior Vena Cava Clamping During Hepatectomy
Status: COMPLETED
Conditions: Hemorrhage
Interventions: PROCEDURE: Infrahepatic inferior vena cava clamping|PROCEDURE: No infrahepatic inferior vena cava clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SR34006 Compared to Placebo in Patients Who Have Completed 6 Months of Treatment for Symptomatic Pulmonary Embolism or Deep Vein Thrombosis
Status: COMPLETED
Conditions: Pulmonary Embolism|Deep Vein Thrombosis
Interventions: DRUG: SR34006 (idraparinux sodium) Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose:
Clinical trial: Limb Health and Socket Pressure in Response to Powered Ankle Protheses
Status: COMPLETED
Conditions: Pressure Ulcer, Ankle|Prosthesis User|Prosthesis Durability|Mobility Limitation|Skin Wound|Amputation; Traumatic, Foot|Amputation|Limb Deficiencies
Interventions: DEVICE: PROPRIO FOOT® by Ossur|DEVICE: Empower ankle by Ottobock
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effectiveness of Kinesio® Tex Tape on Gluteus Medius Activation in Dancers
Status: WITHDRAWN
Conditions: Gluteus Medius Activation
Interventions: OTHER: Airplane Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Laser Therapy Versus Anterior Re-positioning Splint in the Treatment of Disc Displacement With Reduction
Status: COMPLETED
Conditions: Temporomandibular Joint Disorders
Interventions: DEVICE: Laser therapy|DEVICE: anterior re-positioning splint|DEVICE: inactive Laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Yoga Intervention in Head and Neck Cancer Patients Undergoing Concurrent Chemo-Radiation
Status: TERMINATED
Conditions: Head and Neck Cancer
Interventions: BEHAVIORAL: Yoga Video|BEHAVIORAL: Posture and Strengthening Video|BEHAVIORAL: Relaxation Video|BEHAVIORAL: Breath Work Video|BEHAVIORAL: Satisfaction Survey|BEHAVIORAL: Guided Yoga Session|BEHAVIORAL: Written Yoga Instructions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy Study of DE-104 Ophthalmic Solution to Treat Open-Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: DE-104 ophthalmic solution, low concentration|DRUG: DE-104 ophthalmic solution, medium concentration|DRUG: DE-104 ophthalmic solution, high concentration|DRUG: DE-104 vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Trabecular Metal Mesh Tibial Monoblock RSA
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: Trabecular Metal Mesh Tibial Monoblock Knee Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Short-term Investigation of Resveratrol on Fat Metabolism in Morbidly Obese Women Undergoing Gastric Bypass Surgery
Status: UNKNOWN
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Resveratrol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: EFFECT OF ENDOTRACHEAL TUBE DETECTION ON PRESSURE
Status: COMPLETED
Conditions: Pressure Injury
Interventions: OTHER: ENDOTRAKEAL TUBE HOLDER|OTHER: BANDAGE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase III Randomised Trial of Peri-Operative Chemotherapy Versus sUrveillance in Upper Tract Urothelial Cancer (POUT)
Status: UNKNOWN
Conditions: Transitional Cell Carcinoma of Ureter
Interventions: DRUG: Chemotherapy|OTHER: Surveillance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insulin Differences Between African-American and Caucasian Female Adolescents With Polycystic Ovary Syndrome (PCOS)
Status: TERMINATED
Conditions: Polycystic Ovary Syndrome|PCOS
Interventions: OTHER: Frequently Sampled Intravenous Glucose Tolerance Test (FSIVGTT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Intravenous Infusion of Labetalol Versus Magnesium Sulfate
Status: COMPLETED
Conditions: Magnesium Sulfate|Labetalol
Interventions: DRUG: Magnesium sulfate|DRUG: Labetolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of MAGE-3/Melan-A/gp 100/NA17 and rhIL-12 With/Out Low Dose IL-2 in Metastatic Melanoma
Status: COMPLETED
Conditions: Metastatic Melanoma
Interventions: DRUG: MAGE-3/Melan-A/gp100/NA PBMC, rhIL-12 (drug)|DRUG: MAGE-3/Melan-A/gp100/NA17 Peptide-pulsed autologous PBMC, rhIL-12 with IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Ultrasound-guided Versus Blind Insertion of Radial Artery Catheters
Status: TERMINATED
Conditions: Severe Sepsis
Interventions: PROCEDURE: Ultrasound guided radial artery catheterization.|PROCEDURE: Blind insertion of radial artery catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gingival Crevicular Fluid Levels of Sclerostin, Osteoprotegerin (OPG) and RANKL in Health, Disease and After Treatment
Status: COMPLETED
Conditions: Periodontitis
Interventions: OTHER: non surgical periodontal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety of Chitosan as Wine Fining Agent in Shrimp Allergic Patients
Status: UNKNOWN
Conditions: Shellfish Allergy
Interventions: OTHER: Chitosan as wine fining agent|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Dose Response Effects of Pecan Consumption
Status: RECRUITING
Conditions: Dyslipidemias|Overweight and Obesity|Nutrition, Healthy
Interventions: OTHER: Pecan LOW|OTHER: Pecan MID|OTHER: Pecan HIGH|OTHER: CONTROL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Application of ihMT MRI in Multiple Sclerosis
Status: RECRUITING
Conditions: Sclerosis, Multiple
Interventions: DEVICE: inhomogeneous Magnetisation Transfer (ihMT) sequence|DEVICE: inhomogeneous Magnetisation Transfer (ihMT) sequence at 3T
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety, Tolerability and Preliminary Efficacy of Multiple Intra-articular Injections of LRX712 in Patients With Knee OA
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis (OA)
Interventions: DRUG: LRX712|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Intravenous Pulse in Attaining Remission in Refractory Juvenile Idiopathic Arthritis
Status: RECRUITING
Conditions: Refractory Juvenile Idiopathic Arthritis (Despite 2 DMARDs Still Active)
Interventions: DRUG: Solumedrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Endovascular Repair of Juxtarenal Aortic Aneurysm
Status: UNKNOWN
Conditions: Juxtarenal Aortic Aneurysm
Interventions: PROCEDURE: Endovascular Repair of Juxtarenal Aortic Aneurysm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pharmaceutical Grade L-glutamine (Endari) on Glycemic Control in Patients With Diabetes Mellitus Type II
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: L-glutamine|OTHER: No L-glutamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adding Dexmedetomidine to Bupivacaine for Bilateral Erector Spinae Block
Status: NOT_YET_RECRUITING
Conditions: Erector Spinae Block|Lumbar Fusion Surgeries|Dexmedetomidine
Interventions: DRUG: Dexmedetomidine|DRUG: Bupivacain|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Long-term Parenteral Nutrition With SmofKabiven® E in Lung Cancer Patients Under Anticancer Therapy
Status: TERMINATED
Conditions: Cancer-related Malnutrition
Interventions: DRUG: SmofKabiven® E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Carvedilol Controlled-Release (CR) and Atenolol on Central Blood Pressure
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Carvedilol CR|DRUG: Atenolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Supra-inguinal Fascia Iliaca Compartment Block on Postoperative Management in Total Hip Arthroplasty by Posterior Approach
Status: COMPLETED
Conditions: Arthropathy of Hip
Interventions: PROCEDURE: Supra-inguinal fascia iliaca compartment block|DRUG: Multimodal analgesia and PCA morphine pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Assess VPM1002 in Reducing Hospital Admissions and/or Severe Respiratory Infectious Diseases in Elderly in COVID-19 Pandemic
Status: COMPLETED
Conditions: Infection, Respiratory Tract
Interventions: BIOLOGICAL: VPM1002|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Evaluating Safety, Tolerability, and Pharmacokinetics of QRL-101 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: QRL-101|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gleevec/Taxol for Patients With Uterine Papillary Serous Carcinoma
Status: TERMINATED
Conditions: Uterine Cancer
Interventions: DRUG: Imatinib Mesylate|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Sterile Water Feeds for Treatment of Hypernatremia in Extremely Low Birth Weight Infants
Status: COMPLETED
Conditions: Extremely Low Birth Weight Infants|Hypernatremia
Interventions: OTHER: Sterile water feedings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY2775240 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY2775240|DRUG: Placebo|DRUG: Apremilast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Single or Reduced Ports Laparoscopic Gastrectomy for Advanced Gastric Cancer (SPACE-01)
Status: RECRUITING
Conditions: Gastric Cancer|Gastric Adenocarcinoma
Interventions: PROCEDURE: Single port or reduced ports laparoscopic distal gastrectomy and D2 lymph node dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Ischemic Conditioning on Strength and Ambulation in Subjects With PAD
Status: RECRUITING
Conditions: Peripheral Arterial Disease|Peripheral Vascular Disease|Amputation|Lower Limb Amputation Knee|Lower Limb Amputation Above Knee (Injury)|Lower Limb Amputation Below Knee (Injury)
Interventions: PROCEDURE: Ischemic Conditioning Low - Sham Comparator|PROCEDURE: Ischemic Conditioning High - Active Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Training Attentional Awareness and Control in ADHD
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: Sustained Attention Control (SAC) Method|BEHAVIORAL: Scrabble
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact in Older Adults of Reducing Anticholinergic and Sedative Rx Burden on Physical Function Measured by Wearables
Status: RECRUITING
Conditions: Deprescribing Anticholinergic and Sedative Medications|Physical Function
Interventions: DRUG: Deprescribing anticholinergic and sedative mediications
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacodynamic, Efficacy, and Pharmacokinetic Study of DYNE-101 in Participants With Myotonic Dystrophy Type 1
Status: RECRUITING
Conditions: Myotonic Dystrophy Type 1 (DM1)
Interventions: DRUG: DYNE-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Microbiota and Metabolic Signature in Ulcerative Colitis Predicts Anti-Inflammatory Therapy Success
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: Ozanimod|DRUG: TNF Inhibitor|DRUG: Steroids|DRUG: Vedolizumab|DRUG: Ustekinumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Single Session of tACS in a Depressive Episode
Status: COMPLETED
Conditions: Depression|Major Depressive Disorder|Premenstrual Dysphoric Disorder|Depressive Episode
Interventions: DEVICE: XCSITE100 Stimulator Sham|DEVICE: XCSITE100 Stimulator tACS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Immunogenicity of an Adjuvanted Trivalent Influenza Vaccine in Children 6 to <72 Months of Age in Mexico.
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Adjuvanted Trivalent Influenza Vaccine, 1 dose for non-naive subjects (day 1), two doses for naive subjects (day 1 and day 29)|BIOLOGICAL: Non-adjuvanted Trivalent Influenza Vaccine, 1 dose for non-naive subjects (day 1), two doses for naive subjects (day 1 and day 29).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Anidulafungin Plus Voriconazole Versus Voriconazole For The Treatment Of Invasive Aspergillosis
Status: COMPLETED
Conditions: Aspergillosis
Interventions: DRUG: voriconazole|DRUG: anidulafungin|DRUG: voriconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial For The Study of Falciparum Malaria Protein 014 Administered Via Intramuscular Injection in Healthy Adults
Status: UNKNOWN
Conditions: Vaccine Reaction
Interventions: DRUG: FMP014|DRUG: ALFQ
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Identification of the Optimal Treatment Strategy for Complex Appendicitis in the Pediatric Population
Status: COMPLETED
Conditions: Appendicitis|Appendix Mass|Appendicitis Perforated
Interventions: PROCEDURE: Laparoscopic appendectomy|PROCEDURE: Open appendectomy|PROCEDURE: Non-operative treatment|PROCEDURE: Direct appendectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of B-Chronic Lymphocytic Leukemia (B-CLL) With Autologous CD40 Ligand and IL-2-Expressing Tumor Cells
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia (CLL)
Interventions: BIOLOGICAL: CD40 LIGAND AND IL-2-EXPRESSING TUMOR CELLS VACCINE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Interleukin-11 and rhTPO for Recurrent Colorectal Cancer Patients With Thrombocytopenia
Status: UNKNOWN
Conditions: Recurrent Colorectal Carcinoma|Thrombopenia
Interventions: DRUG: rhTPO|DRUG: irinotecan|DRUG: Raltitrexed|RADIATION: radiotherapy|DRUG: rhIL-11
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apalutamide in Treating Patients With Prostate Cancer Who Are in Active Surveillance
Status: TERMINATED
Conditions: Prostate Adenocarcinoma
Interventions: DRUG: Apalutamide|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pressure-controlled vs Volume Controlled Ventilation on RV Function During OLV
Status: COMPLETED
Conditions: Lung Diseases
Interventions: OTHER: The PCV-VCV group|OTHER: The VCV-PCV group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anesthetic Efficacy of 2% Mepivacaine Versus 4% Articaine
Status: UNKNOWN
Conditions: Symptomatic Irreversible Pulpitis
Interventions: DRUG: mepivicane hydrochloride|DRUG: articane hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Endocrinology Profile in Patients Undergoing Clomiphene, Letrozole, and Combination Clomiphene and Letrozole Cycles
Status: WITHDRAWN
Conditions: Infertility
Interventions: DRUG: Clomiphene|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radio Frequency Ablation Versus Stripping of Great Saphenous Vein in Management of Primary Varicose Veins , Comparative Study
Status: UNKNOWN
Conditions: Varicose Veins
Interventions: PROCEDURE: stripping of great saphenous vein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Single Port Laparoscopic Cholecystectomy Versus Four Port Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Cholecystectomy, Laparoscopic
Interventions: DEVICE: Laparoscopic cholecystectomy surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperalgesia in Methadone-Maintained Patients: Can it be Treated?
Status: COMPLETED
Conditions: Opioid-Induced Hyperalgesia
Interventions: DRUG: Gabapentin;|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy of Sacrocolpopexy, the Amreich-Richter Procedure and Transvaginal Mesh
Status: ACTIVE_NOT_RECRUITING
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: Laparoscopic sacrocolpopexy|PROCEDURE: Transvaginal mesh procedure|PROCEDURE: Amreich-Richter procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TAK-925 in Healthy Volunteers and Participants With Narcolepsy
Status: COMPLETED
Conditions: Healthy Participants|Narcolepsy
Interventions: DRUG: TAK-925|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Intranasal Nerve Growth Factor for Traumatic Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: DRUG: nerve growth factor|DRUG: nomral saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Patients With Ependymoma
Status: TERMINATED
Conditions: Ependymoma
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Feasibility Pilot Clinical Study of a Large-Diameter Nerve Cap for Protecting and Preserving Terminated Nerve Ends
Status: RECRUITING
Conditions: Symptomatic Neuroma|Amputation|Chronic Nerve Pain
Interventions: DEVICE: Axoguard Nerve Cap®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Decision Aid About Life-sustaining Therapies
Status: COMPLETED
Conditions: Decision Making|Resuscitation|Intensive Care Unit|Goals-of-care|Shared-decision Making
Interventions: BEHAVIORAL: decision aid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Dupilumab Severe Eosinophilic Chronic Sinusitis Without Nasal Polyposis
Status: RECRUITING
Conditions: Severe Eosinophilic Chronic Sinusitis Without Nasal Polyposis
Interventions: DRUG: Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Common Bean Baked Snack Consumption on Subjective Satiety, Energy Intake and Glycemic Response in People With Overweight and Normal Weight
Status: COMPLETED
Conditions: Overweight|Healthy
Interventions: OTHER: Common bean baked snack|OTHER: Cooked beans|OTHER: White bread|OTHER: Anhydrous glucose (first session) (for glycemic index determination)|OTHER: Anhydrous glucose (second session) (for glycemic index determination)|OTHER: Common bean baked snack (for glycemic index determination)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measuring the Impact of a Mobile Health System to Support Healthy Pregnancies and Improve Newborn Survival
Status: COMPLETED
Conditions: High Perinatal Mortality|High Neonatal Mortality|Low Antenatal Care Service Utilization|Low Postnatal Care Service Utilization
Interventions: OTHER: mCARE-II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Drug-Drug Interaction Study to Investigate Effects of Voclosporin on Pharmacokinetics of Simvastatin
Status: COMPLETED
Conditions: Drug-drug Interaction
Interventions: DRUG: Simvastatin|DRUG: Voclosporin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Encorafenib Plus Cetuximab in a Neoadjuvant Setting in Patients With BRAF Mutation Localised Colon or Upper Rectum Cancer
Status: RECRUITING
Conditions: Colorectal Cancer|BRAF V600E Mutation Positive
Interventions: DRUG: Encorafenib Oral Capsule + Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)
Status: RECRUITING
Conditions: Healthy Volunteers|Overweight
Interventions: OTHER: Sucralose|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Combined Effects of Buteyko Breathing Technique and Chest Wall Mobilization on Pulmonary Functions and Quality of Life
Status: RECRUITING
Conditions: Chronic Smokers
Interventions: OTHER: Buteyko breathing technique|OTHER: Chest Wall Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Potts-shunt for the Treatment of Pediatric Patients With Severe Pulmonary Hypertension
Status: RECRUITING
Conditions: Pulmonary Artery Hypertension
Interventions: PROCEDURE: Comprehensive therapy combined Potts-shunt procedure and conventional drug therapy|DRUG: Only conventional drug therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inpatient Single Dose Interventions for Alcohol Use Disorder
Status: COMPLETED
Conditions: Alcohol Use Disorder, Severe
Interventions: DRUG: Naltrexone 380 MG|DRUG: Ketamine Hydrochloride|BEHAVIORAL: Enhanced linkage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotic Supplementation on Fecal Microbiota, Nutritional Status, Metabolic and Inflammatory Parameters in Patients With Type 2 Diabetes Mellitus
Status: RECRUITING
Conditions: Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Safety and Tolerability of JS012 in Advanced or Metastatic Solid Tumors
Status: TERMINATED
Conditions: Advanced or Metastatic Solid Tumors
Interventions: DRUG: JS012|COMBINATION_PRODUCT: JS012 combine with chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antazoline in Rapid Cardioversion of Paroxysmal Atrial Fibrillation
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DRUG: antazoline|DRUG: 0.9% saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Epigallocatechin-3-gallate (EGCG) for Skin Prevention in Patients With Breast Cancer Receiving Adjuvant Radiotherapy
Status: UNKNOWN
Conditions: Breast Neoplasms|Dermatitis|Prevention & Control|Epigallocatechin Gallate
Interventions: DRUG: EGCG|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Examining the Effectiveness of a Mobile App on Self-care for a Colostomy
Status: UNKNOWN
Conditions: Colostomy
Interventions: DEVICE: colostomy self-care app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Different Local Anesthetic Volumes in Brachial Plexus Block
Status: COMPLETED
Conditions: Diaphragmatic Disorder
Interventions: PROCEDURE: Low volume interscalene brachial plexus block|PROCEDURE: Intermediate volume interscalene brachial plexus block|PROCEDURE: High volume interscalene brachial plexus block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prednisone Plus Chloroquine for the Treatment of Hyper-reactive Malarial Splenomegaly
Status: WITHDRAWN
Conditions: Hyper-reactive Malarial Splenomegaly|Malaria|Anaemia
Interventions: DRUG: prednisone induction - chloroquine|DRUG: Chloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tailored vs. Empirical Helicobacter Pylori Infection Treatment
Status: NOT_YET_RECRUITING
Conditions: Helicobacter Pylori Infection
Interventions: DIAGNOSTIC_TEST: Clarithromycin (mutations in the 23S rRNA gene, A2134G, A2142G and A2142C mutations) and levofloxacin resistance (mutations in the gyrA gene) PCR test|DRUG: Empirically H. pylori eradication treatment with bismuth quadruple therapy (Pylera®)|DRUG: PPI, amoxicillin 1 g and clarithromycin 500 mg, twice daily, for 10 days|DRUG: PPI, amoxicillin 1g and levofloxacin 250 mg, twice daily, for 10 days|DRUG: Bismuth quadruple therapy (Pylera®) for 10 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Encapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration.
Status: COMPLETED
Conditions: Periapical Periodontitis
Interventions: PROCEDURE: Regenerative Endodontic Procedure|PROCEDURE: Conventional Root Canal Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Follow-Up Gene Therapy Study for Leber Congenital Amaurosis OPTIRPE65 (Retinal Dystrophy Associated With Defects in RPE65)
Status: COMPLETED
Conditions: Leber Congenital Amaurosis (LCA)|Eye Diseases|Eye Diseases, Hereditary|Retinal Diseases
Interventions: BIOLOGICAL: AAV OPTIRPE65
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Quality of Life and Efficacy Evaluation of Patient Self-monitoring Their Oral Anticoagulation Therapy
Status: COMPLETED
Conditions: Anticoagulants|Quality of Life|Drug Monitoring|Pharmacy|Ambulatory Care
Interventions: OTHER: Self-monitoring and adjustment of oral anticoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cobalamin Supplementation During Infancy; Effect on B-vitamin Status, Growth and Psychomotor Development
Status: COMPLETED
Conditions: Vitamin B 12 Deficiency
Interventions: DRUG: Hydroxycobalamin (Vitamin B12 Depot, Nycomed Pharma)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cyclophosphamide Versus Anti-thymocyte Globulin for GVHD Prophylaxis After RIC Allo-SCT
Status: COMPLETED
Conditions: Graft vs Host Disease
Interventions: DRUG: Cyclophosphamide|DRUG: Anti-Thymocyte Globulin|DRUG: Conditioning regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: To Investigate If Single Doses Of GSK618334 Are Safe And To Investigate Blood Levels Of GSK618334
Status: COMPLETED
Conditions: Substance Dependence
Interventions: DRUG: GSK618334|DRUG: GSK618334 matching placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: |Primary Purpose: TREATMENT
Clinical trial: Investigate Efficacy, Safety, and Pharmacokinetics of Enzastaurin for the Prevention of Arterial Events in Patients With Vascular Ehlers-Danlos Syndrome.
Status: SUSPENDED
Conditions: Vascular Ehlers-Danlos Syndrome
Interventions: DRUG: Enzastaurin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Gingiva Mesenchymal Stem Cells Treatment of Chronic Periodontitis
Status: UNKNOWN
Conditions: Periodontitis
Interventions: BIOLOGICAL: GMSCs and collagen scaffolds|BIOLOGICAL: Collagen scaffolds|PROCEDURE: Open flap debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT