pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Promoting Health Through Parent Empowerment and the Activation of Routines (PrO-PEAR)
Status: COMPLETED
Conditions: Down Syndrome
Interventions: BEHAVIORAL: Promoting Health through Parent Empowerment and the Activation of Routines|BEHAVIORAL: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Role of the P2Y12 Receptor in Tissue Factor Induced Coagulation
Status: COMPLETED
Conditions: Healthy Volunteers|Sepsis
Interventions: DRUG: Prasugrel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Herbal Dentifrice for Management of Dentinal Hypersensitivity
Status: RECRUITING
Conditions: Dentinal Hypersensitivity|Chronic Periodontitis
Interventions: DRUG: Toothpaste Preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Study of Different Dose Rituximab in the Treatment of ITP
Status: COMPLETED
Conditions: Purpura, Thrombocytopenic, Idiopathic|Immune Thrombocytopenia
Interventions: DRUG: Rituximab|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Post-stroke Spasticity of the Upper Limb
Status: COMPLETED
Conditions: Post-stroke Upper Limb Spasticity
Interventions: DRUG: IncobotulinumtoxinA (Xeomin)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Bmi-1 on Protein and Molecular Levels in Oral Dysplasia and Squamous Cell Carcinoma: A Diagnostic Study
Status: UNKNOWN
Conditions: Oral Squamous Cell Carcinoma
Interventions: DIAGNOSTIC_TEST: Bmi-1 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Extension Study to Assess Tolerability and Safety of Enteric-coated Mycophenolate Sodium in Renal Transplant Recipients Who Received Mycophenolate Mofetil
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: Enteric-Coated Mycophenolate Sodium (EC-MPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Incentive Integrated E-IBD Chronic Disease Management Model on the Quality of Life in IBD Patients
Status: NOT_YET_RECRUITING
Conditions: Inflammatory Bowel Diseases|Crohn Disease|Ulcerative Colitis
Interventions: OTHER: education ,psycological support and social support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy
Status: UNKNOWN
Conditions: NAION( Non-arteritic Anterior Ischemic Optic Neuropathy)
Interventions: DRUG: placebo|DRUG: Intravenous methylprednisolone|DRUG: normobaric oxygen with face mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neuroprotective Study of Electroacupuncture Pretreatment in Patients Undergoing Cardiac Surgery
Status: COMPLETED
Conditions: Stroke|Brain Injuries
Interventions: PROCEDURE: non electroacupuncture stimulation|PROCEDURE: Electroacupuncture pretreatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Antioxidant Intake on Resistin Levels In Patients With Gum Disease and Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus|Periodontitis
Interventions: OTHER: Alpha lipoic acid|PROCEDURE: Scaling and Root planing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Intraventricular Liposomal Encapsulated Ara-C (DepoCyt) in Patients With Recurrent Glioblastoma
Status: TERMINATED
Conditions: Glioblastoma Multiforme|Glioma|Astrocytoma|Brain Tumor
Interventions: DRUG: ITV DepoCyt + Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Ranging Trial of 4 Doses of Indacaterol Delivered Via the TWISTHALER® Device in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: indacaterol|DRUG: formoterol|DRUG: placebo to indacaterol|DRUG: placebo to formoterol|DRUG: short acting β2- agonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgical Versus Nonsurgical Treatment of Fibular Fractures: A Prospective Randomized Study
Status: UNKNOWN
Conditions: Ankle Fracture|Malleolus Fracture|Medial Malleolus Fracture|Bimalleolar Fracture|Trimalleolar Fracture
Interventions: PROCEDURE: Nonsurgical|PROCEDURE: Surgical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transbronchial Lung Cryobiopsy in Undiagnosed Acute Respiratory Failure
Status: RECRUITING
Conditions: Acute Respiratory Failure|Acute Respiratory Distress Syndrome
Interventions: PROCEDURE: Transbronchial lung cryobiopsy|PROCEDURE: Transbronchial lung biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: PirfenidoneVsPlacebo as Prophylaxis Against Acute Radiation-induced Lung Injury Following HFRT in Breast Cancer Patients
Status: RECRUITING
Conditions: Acute Lung Injury|Prevention
Interventions: DRUG: Pirfenidone/Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Emotion Recognition and Empathy Focused Education Program Applied to Earthquake Survivors on Anxiety, Rumination and Post-traumatic Growth Levels of Children
Status: NOT_YET_RECRUITING
Conditions: Anxiety
Interventions: BEHAVIORAL: The effect of emotion recognition and empathy focused education program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combining a Caregiver Intervention With Aricept Treatment for Mild to Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease|Caregivers
Interventions: BEHAVIORAL: Psychosocial information, counseling, and support|DRUG: Donepezil (Aricept)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Benefit of Antiviral Treatment With Valganciclovir on Congenital CMV Infection-related Deafness on Hearing and Balance
Status: TERMINATED
Conditions: Congenital Cytomegalovirus (CMV)
Interventions: DRUG: Valganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Silk Suture and Tissue Adhesive for Wound Closure After Impacted Tooth
Status: COMPLETED
Conditions: Tooth, Impacted|Tooth Diseases
Interventions: PROCEDURE: Surgery of impacted mandibular wisdom teeth|PROCEDURE: Surgery of impacted mandibular wisdom teeth (the other side)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 1/2 Study of OBI-999 in Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Locally Advanced Solid Tumor
Interventions: DRUG: OBI-999|DRUG: OBI-999
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Two Reduced Sirolimus Doses in Treatment of de Novo Coronary Artery Lesions (REDOX)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Bx VELOCITY Stent containing 45% and 70% of Sirolimus dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Reduction and Fixation of Metatarsal Neck Fracture by Metaizeau's Technique
Status: COMPLETED
Conditions: Displaced Metatarsal Neck Fracture
Interventions: DEVICE: Reduction and fixation of metatarsal neck fracture by metaizeau's technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Hygiene-dietetic Habits and Treatment Adherence on the Effectiveness of the Gastroesophageal Reflux Illness Treatment With Rabeprazol
Status: TERMINATED
Conditions: Gastroesophageal Reflux
Interventions: OTHER: Non-Pharmacologic Treatment|DRUG: Rabeprazole
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3)
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: Donanemab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic-pharmacodynamic Interaction Between Three Different Single Doses of BIA 9-1067 and a Single-dose of Controlled-release 100/25 mg Levodopa/Benserazide
Status: COMPLETED
Conditions: Parkinson's Disease (PD)
Interventions: DRUG: BIA 9-1067|DRUG: Placebo|DRUG: Madopar® HBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 18F-AV-1451 and Florbetapir F 18 PET (Positron Emission Tomography) Imaging in Subjects at Risk for Chronic Traumatic Encephalopathy
Status: COMPLETED
Conditions: Chronic Traumatic Encephalopathy
Interventions: DRUG: florbetapir F 18|DRUG: Flortaucipir F18
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Exercise Referral Schemes Enhanced by Self-Management Strategies to Battle Sedentary Behaviour
Status: COMPLETED
Conditions: Physical Activity|Biological Aging|Frail Older Adults|Controlled Clinical Trials, Randomized|Sedentary Behaviour|Exercise Referral Schemes|Physical Function
Interventions: BEHAVIORAL: ERS and/or Self-management Strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Short Duration Combination Therapy With Daclatasvir, Asunaprevir, BMS-791325 and Sofosbuvir in Subjects Infected With Chronic Hepatitis-C (FOURward Study)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: DCV/ASV/BMS-791325|DRUG: Ribavirin|DRUG: Sofosbuvir|DRUG: Peginterferon α-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial to Assess the Effects of Green Tea in Oral Leukoplakia
Status: TERMINATED
Conditions: Oral Leukoplakia
Interventions: DRUG: Lozenge Intake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Drains Ablation Post Total Hip Arthroplasty : Search for the Least Painful Technique
Status: UNKNOWN
Conditions: Total Hip Arthroplasty|Drain Insertion Site
Interventions: PROCEDURE: drain ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cellular and Humoral Immune Response to Primary and Secondary Immunization With Subvirion H5N1 Vaccines
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza Virus Vaccine, Monovalent A/H5N1 A/Indonesia/05/2005
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Using Different Varnishes on Dentin Hypersensitivity; Na Fluoride and Nano-silver Fluoride
Status: UNKNOWN
Conditions: Dentin Hypersensitivity
Interventions: BEHAVIORAL: Citrine 5 % sodium fluoride|BEHAVIORAL: concocted nano-silver fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Radiotherapy for Patients With NK/T Cell Lymphoma
Status: RECRUITING
Conditions: Lymphoma, Extranodal NK-T-Cell
Interventions: DRUG: Pembrolizumab|RADIATION: Involved Field Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety of the HIV-1 Vaccine MVA-B in Chronic HIV-1 Infected Patients Successfully Treated With HAART
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: Vaccination|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Electrical Intra-cutaneous Half-sine Stimulation for Optimized Preferential C-fiber Activation
Status: COMPLETED
Conditions: Pain Perception|Secondary Hyperalgesia
Interventions: DIAGNOSTIC_TEST: Study Intervention: 25 ms half-sine wave stimulation|DIAGNOSTIC_TEST: Control Intervention: 500 µs rectangular shaped stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bipolar Transurethral Enucleation Versus Resection in the Treatment of Benign Prostatic Hyperplasia: a Comparative Study
Status: RECRUITING
Conditions: Prostatic Hyperplasia|Prostate Enucleation
Interventions: DEVICE: Bipolar Bowa device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Drug-Drug Interaction Between ABBV-903 and Midazolam in Adult Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: ABBV-903|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LUX-Breast 1: BIBW 2992 (Afatinib) in HER2-positive Metastatic Breast Cancer Patients After One Prior Herceptin Treatment
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: BIBW 2992|DRUG: trastuzumab|DRUG: vinorelbine|DRUG: vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Efficacy and Safety of GSK1605786A in the Treatment of Subjects With Moderately-to-Severely Active Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: GSK1605786A|DRUG: GSK1605786A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of the Efficacy and the Safety of RO6889450 (Ralmitaront) vs Placebo in Patients With an Acute Exacerbation of Schizophrenia or Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenia, Schizoaffective Disorder
Interventions: DRUG: RO6889450|DRUG: Placebo|DRUG: Risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BRIEF-PCI: Brief Infusion of Eptifibatide Following Percutaneous Coronary Intervention
Status: COMPLETED
Conditions: Coronary Artery Disease|Myocardial Infarction
Interventions: DRUG: eptifibatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CPI-613 Given With Metformin in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML)
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia, in Relapse|Acute Myeloid Leukemia Refractory|Granulocytic Sarcoma
Interventions: DRUG: CPI 613|DRUG: Metformin|BIOLOGICAL: Blood draws|PROCEDURE: Bone marrow biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Phase II Trial of SHR-1210 Combined With Preoperative Chemotherapy or Apatinib for Locally Advanced ESCC
Status: RECRUITING
Conditions: Locally Advanced Esophageal Squamous Cell Carcinoma
Interventions: DRUG: SHR-1210+docetaxel+nedaplatin|DRUG: SHR-1210+Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methodological Study of the Effect of a Lotion Containing Nature Based Microbial Extract on Atopic Skin
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: OTHER: Biodiversity intervention by inactivated microbial extract|OTHER: Placebo intervention by colored lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Fenofibrate for Patients With Primary Biliary Cirrhosis Who Had An Inadequate Response to Ursodeoxycholic Acid
Status: UNKNOWN
Conditions: Primary Biliary Cirrhosis
Interventions: DRUG: Fenofibrate|DRUG: UDCA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Safety, Tolerability, and Pharmacokinetics of Oral AZD0233 Compared With Placebo in Healthy Adult Participants.
Status: RECRUITING
Conditions: Dilated Cardiomyopathy
Interventions: DRUG: AZD0233|DRUG: AZD0233 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of a built-in Insulin Calculator Feature on Diabetes Control - Pilot Study
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: FreeStyle InsuLinx|DEVICE: FreeStyle Freedom Lite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Submacular Hemorrhage Associated With Retinal Arterial Macro Aneurysm
Status: COMPLETED
Conditions: Submacular Hemorrhage|Ruptured Retinal Arterial Macro Aneurysms
Interventions: PROCEDURE: Vitrectomy for submacular hemorrhage|DRUG: subretinal injection of tissue-plasminogen activator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Topical Valproic Acid in Preventing Hair Loss
Status: COMPLETED
Conditions: Androgenetic Alopecia|Male Pattern Baldness
Interventions: DRUG: Valproic Acid|DRUG: Control placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Higher Protein Dosing in Critically Ill Patients Ultrasound a Sub-study
Status: WITHDRAWN
Conditions: Critical Illness|Malnutrition
Interventions: OTHER: Usual Care|OTHER: Higher Protein/Amino Acid Group|OTHER: Ultrasound measure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sorafenib in Treating Patients With Relapsed Chronic Lymphocytic Leukemia
Status: TERMINATED
Conditions: Refractory Chronic Lymphocytic Leukemia|Stage I Chronic Lymphocytic Leukemia|Stage II Chronic Lymphocytic Leukemia|Stage III Chronic Lymphocytic Leukemia|Stage IV Chronic Lymphocytic Leukemia
Interventions: DRUG: sorafenib tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spectra Breast Implant Study
Status: WITHDRAWN
Conditions: Augmentation|Augmentation Revision|General Breast Enlargement|Post-lactational Involution|Asymmetry
Interventions: DEVICE: Mentor Spectra/Becker 80 Breast Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes of Esophageal Self Dilation for Benign Refractory Esophageal Stricture Management
Status: COMPLETED
Conditions: Esophageal Dilation|Refractory Benign Esophageal Stricture
Interventions: DEVICE: Esophageal self-dilation therapy|PROCEDURE: Endoscopic therapy with esophageal dilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long Term Extension Study of WA19926 (NCT01007435) of Tocilizumab (RoActemra/Actemra) in Participants With Early, Moderate to Severe Rheumatoid Arthritis (RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Chiropractic Activator Adjustments on Mental Rotation and Line Judgment Reaction Time
Status: COMPLETED
Conditions: Cognition - Other
Interventions: OTHER: Chiropractic adjustment|OTHER: Sham chiropractic adjustment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exploring the Effect of Inorganic Nitrates on the Human Microvascular Physiology - a Pilot Study.
Status: COMPLETED
Conditions: Aging
Interventions: OTHER: Crossover intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lumiliximab With Fludarabine, Cyclophosphamide, and Rituximab (FCR) Versus FCR Alone in Subjects With Relapsed Chronic Lymphocytic Leukemia (CLL)
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: FCR + Lumiliximab|DRUG: FCR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SARS-CoV-2-Neutralizing Monoclonal COVID-19 Antibody DZIF-10c by Infusion
Status: COMPLETED
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: DZIF-10c|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: East-West Collaboration Treatment Using Bee Venom Acupuncture and NSAIDs for Chronic Cervicalgia
Status: COMPLETED
Conditions: Chronic Non-specific, Uncomplicated Neck Pain
Interventions: PROCEDURE: Bee Venom Acupuncture|DRUG: Loxoprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thoracic Epidural Anesthesia Reduces Mortality and Rehospitalization for Patients With Heart Failure With Reduced Ejection Fraction
Status: COMPLETED
Conditions: Heart Failure With Reduced Ejection Fraction|Thoracic Epidural Anesthesia
Interventions: COMBINATION_PRODUCT: TEA plus GDMT|DRUG: GDMT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Maternal Pomegranate Juice on Brain Injury in Infants With Intrauterine Growth Restriction (IUGR)
Status: COMPLETED
Conditions: Intrauterine Growth Restriction
Interventions: DIETARY_SUPPLEMENT: Pomegranate Juice|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Trial of Cobicistat and Gemcitabine and Nab-Paclitaxel in Patients With Advanced Stage or Metastatic Pancreatic Ductal Adenocarcinoma
Status: TERMINATED
Conditions: CYP3A Inhibitor|Advanced Stage or Metastatic Pancreatic Ductal Adenocarcinoma|Pancreatic Cancer|Pancreatic Adenocarcinoma|Pancreatic Neoplasm
Interventions: DRUG: Cobicistat Oral Tablet|DRUG: Gemcitabin|DRUG: Nab paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can we Save the Rectum by Watchful Waiting or TransAnal Surgery Following (Chemo)Radiotherapy Versus Total Mesorectal Excision for Early REctal Cancer?
Status: RECRUITING
Conditions: Adenocarcinoma of the Rectum
Interventions: PROCEDURE: Standard TME surgery|DRUG: Long course concurrent chemoradiation with capecitabine and radiotherapy|RADIATION: Short course radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Caudal Block vs Local Wound Infiltration for Hernia Repair in Children
Status: COMPLETED
Conditions: Anesthesia
Interventions: PROCEDURE: Bupivacain- Caudal|PROCEDURE: Bupivacaine- Local
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Memantine and Cognitive Dysfunction in Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Memantine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NGR-hTNF in Combination With an Anthracycline in Platinum-resistant Ovarian Cancer (NGR018)
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: NGR-hTNF|DRUG: Pegylated liposomal doxorubicin|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Intravenous Calcium and Myocardial Diastolic Dysfunction During Separation From Cardiopulmonary Bypass
Status: TERMINATED
Conditions: Diastolic Dysfunction
Interventions: DRUG: Calcium Chloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Empirical Treatment Against Cytomegalovirus and Tuberculosis in HIV-infected Infants With Severe Pneumonia
Status: ACTIVE_NOT_RECRUITING
Conditions: Pneumonia|HIV/AIDS|Tuberculosis|Cytomegalovirus Infections
Interventions: DRUG: Valganciclovir Oral Solution [Valcyte]|DRUG: Tuberculostatic Agents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of S64315 Administred Intravenously in Patients With Acute Myeloid Leukaemia or Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Acute Myeloid Leukaemia (AML)|Myelodysplastic Syndrome (MDS)
Interventions: DRUG: S64315 once a week|DRUG: S64315 twice a week
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ph I Trial of NAM NK Cells and IL-2 for Adult Pts With MM and NHL
Status: COMPLETED
Conditions: Multiple Myeloma|Non-Hodgkin Lymphoma|Diffuse Large B Cell Lymphoma|Mantle-Cell Lymphoma|Follicular Lymphoma|Indolent B Cell Lymphoma|Primary Mediastinal Lymphoma|Lymphoplasmacytic Lymphoma
Interventions: BIOLOGICAL: Nicotinamide Expanded Haploidentical or Mismatched Related Donor Natural Killer Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CAR T-cell Therapy in Combination With Glofitamab for Relapsed/Refractory Large B-Cell Lymphoma With High-Risk Prognostic Factors
Status: NOT_YET_RECRUITING
Conditions: Large B-cell Lymphoma
Interventions: BIOLOGICAL: CAR T-cell therapy|DRUG: Glofitamab|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydrochloric Acid Lock Therapy for Central Line-associated Bloodstream Infections
Status: RECRUITING
Conditions: Central Line-associated Bloodstream Infection (CLABSI)
Interventions: DRUG: Hydrochloric Acid (2 M)|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Of Tasquinimod In Asian Chemo-Naïve Patients With Metastatic Castrate-Resistant Prostate Cancer
Status: TERMINATED
Conditions: Prostatic Neoplasms, Castration-Resistant
Interventions: DRUG: Tasquinimod|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Leukocyte Antigen (HLA) Class I Haplotype Mismatched Natural Killer Cell Infusions
Status: COMPLETED
Conditions: Lymphoma|Myeloma|Leukemia
Interventions: BIOLOGICAL: NK-Cell Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tyrosine Kinase Inhibitors in Metastastic Adenoid Cystic Carcinoma
Status: RECRUITING
Conditions: Carcinoma, Adenoid Cystic
Interventions: DRUG: EGFR-TK Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Pharmacokinetics and Pharmacodynamics of Hydroxychloroquine in COVID-19 Intensive Care Unit Patients
Status: TERMINATED
Conditions: Sars-CoV2
Interventions: DRUG: Hydroxychloroquine (HCQ)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD1705 in Participants With Dyslipidemia
Status: RECRUITING
Conditions: Cardiovascular
Interventions: DRUG: AZD1705|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cells (MSCs) for Perianal Fistula
Status: WITHDRAWN
Conditions: Rectal Fistula
Interventions: BIOLOGICAL: OSSM-001|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exelon Patch and Combination With Memantine Comparative Trial
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Rivastigmine transdermal patch (Exelon patch), memantine|DRUG: Rivastigmine transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Long-Term Gait Development in Infants With Neonatal Encephalopathy Using Infant Treadmill
Status: TERMINATED
Conditions: Hypoxic-Ischemic Encephalopathy|Periventricular Leukomalacia|Intraventricular Hemorrhage Neonatal|Bilirubin Encephalopathy|Kernicterus|Hypoglycemia, Neonatal|Cerebral Infarction
Interventions: DEVICE: Baby treadmill|BEHAVIORAL: Conventional physical rehabilitation training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of GB001 Recombinant Peptide Spray in Subjects With Mild Recurrent Aphthous Ulcers
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DRUG: GB001 recombinant peptide spray low dose group、high dose group|DRUG: GB001 recombinant peptide spray placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Oral AGN 203818 for the Relief of Irritable Bowel Syndrome Pain
Status: TERMINATED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: AGN 203818|DRUG: AGN 203818|DRUG: AGN 203818|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Pilocarpine HCl Ophthalmic Solution in Participants With Presbyopia
Status: NOT_YET_RECRUITING
Conditions: Presbyopia
Interventions: DRUG: Pilocarpine HCl Ophthalmic Solution|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancement of Quality of Work And Life
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease|Ataxia|Hereditary Spastic Paraparesis|Parkinsonism
Interventions: BEHAVIORAL: Participatory workplace intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Epoetin Beta (NeoRecormon) in Anemic Participants With Diabetes and Chronic Renal Failure Who Are Not on Dialysis
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Epoetin beta
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study of Variation in Breath Holding Times at Various Phases of Respiration During the Course of Radiotherapy Including the Effect of Respiratory Training in Lung Cancer Patients
Status: UNKNOWN
Conditions: Small Cell Lung Cancer|Non Small Cell Lung Cancer
Interventions: OTHER: Respiratory Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Light-emitting Diode (LED) Photobiomodulation in the Extraction of Retained Lower Third Molars
Status: UNKNOWN
Conditions: Pain, Postoperative|Edema|Trismus|Quality of Life
Interventions: RADIATION: LED group|RADIATION: Sham group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Sufentanil Transdermal System in Patients With Chronic Pain Due to Cancer
Status: WITHDRAWN
Conditions: Chronic Pain
Interventions: DRUG: Sufentanil|DRUG: Sustained Release Morphine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Psychoeducative Program for Improving Quality of Life in Fibromyalgic Patients [Study Protocol]
Status: UNKNOWN
Conditions: Fibromyalgia
Interventions: BEHAVIORAL: Psychoeducative program in fibromyalgic patients
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Analysis of Non-invasive Ventilatory Support Modes: High Flow Nasal Cannula and Non-invasive Ventilation
Status: UNKNOWN
Conditions: Asthma Acute
Interventions: OTHER: High Flow Nasal cannula|OTHER: NIV Noninvasive Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Multiple Behavioral Science Strategies to Increase Flu-Shot Rates at a Large Retail Pharmacy
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BEHAVIORAL: Flu shot text messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Fish Oil for Reduction of Atrial Fibrillation After Cardiac Surgery
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Omega Three Polyunsaturated fatty acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TACE Plus Camrelizumab and Apatinib for Unresectable Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Unresectable Hepatocellular Carcinoma|Transarterial Chemoembolization|Camrelizumab|Apatinib
Interventions: COMBINATION_PRODUCT: TACE plus camrelizumab and apatinib|COMBINATION_PRODUCT: Camrelizumab and apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Radiation Therapy in Treating Patients With Peripheral Neuroectodermal Tumors, Ewing's Sarcoma, Wilms' Tumor, or Bone Cancer
Status: COMPLETED
Conditions: Kidney Cancer|Sarcoma
Interventions: DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: vincristine sulfate|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Navtemadlin and Radiation Therapy in Treating Patients With Soft Tissue Sarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Resectable Soft Tissue Sarcoma|Soft Tissue Sarcoma
Interventions: DRUG: Navtemadlin|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin Injection for Functional Popliteal Artery Entrapment Syndrome
Status: WITHDRAWN
Conditions: Functional Popliteal Artery Entrapment Syndrome|Popliteal Artery Entrapment Syndrome
Interventions: DRUG: Dysport
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Study to Assess Safety and Efficacy of BAT2020 in Hospitalized COVID-19 Patients
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: BAT2020
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Ketamine for Procedural Sedation
Status: UNKNOWN
Conditions: Bone Fractures|Dislocations
Interventions: DRUG: IN ketamine|DRUG: IV ketamine|DRUG: IN saline 0.9%|DRUG: IV saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Supporting Our Valued Adolescents Pilot Randomized Controlled Trial
Status: COMPLETED
Conditions: Depression|Anxiety
Interventions: BEHAVIORAL: Supporting Our Valued Adolescents (SOVA)|OTHER: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Dose-Comparison Study to Evaluate the Safety and Immunogenicity of MEDI-517 (GSK 580299) in Healthy Adult Females
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: BIOLOGICAL: MEDI-517 HPV-16/18 VLP AS04 vaccine (Formulation 1)|BIOLOGICAL: MEDI-517 HPV-16/18 VLP AS04 vaccine (Formulation 2)|BIOLOGICAL: MEDI-517 HPV-16/18 VLP AS04 vaccine (Formulation 3)|BIOLOGICAL: MEDI-517 HPV-16/18 VLP with Al(OH)3 (Formulation 4)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Patients With Cystic Fibrosis, Mild Lung Disease, and P. Aeruginosa
Status: COMPLETED
Conditions: Cystic Fibrosis|Lung Infection|Pseudomonas Aeruginosa
Interventions: DRUG: AZLI 75 mg three times daily (TID)|DRUG: Placebo three times daily (TID)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Papillomavirus Epidemiology in Nigeria
Status: COMPLETED
Conditions: Human Papillomavirus 18|Cervical Intraepithelial Neoplasia|Human Papillomavirus 16|Uterine Cervical Neoplasms
Interventions: DEVICE: OncoE6|DEVICE: EVA System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Presacral Nerve Block Versus Sham Block on Post-operative Pain for Total Laparoscopic Hysterectomy
Status: NOT_YET_RECRUITING
Conditions: Post-operative Pain
Interventions: DRUG: Ropivacaine injection|DRUG: Normal saline injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 68Ga-FAP-CHX PET/CT : Dosimetry and Preliminary Clinical Translational Studies
Status: RECRUITING
Conditions: Tumor|Positron-Emission Tomography
Interventions: DRUG: 68Ga-FAP-CHX|DRUG: 68Ga-FAP-CHX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Glycemic Control in T2DM Through Non-Surgical Periodontal Therapy
Status: COMPLETED
Conditions: Chronic Periodontitis|Type 2 Diabetes Mellitus
Interventions: DRUG: Metronidazole|PROCEDURE: Scaling Root Planing|BEHAVIORAL: Oral Hygiene Instructions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I Study of Milatuzumab for Graft Versus Host Disease
Status: TERMINATED
Conditions: GVHD (Acute or Chronic)|Acute Myeloid or Lymphoblastic Leukemia (AML or ALL)|Myelodysplastic Syndrome|Chronic Myelogenous Leukemia (CML)|Multiple Myeloma (MM)|Non-Hodgekin Lymphoma (NHL-both Follicular & Diffuse Large Cell)|Chronic Lymphocytic Leukemia or Small Lymphocytic Leukemia (CLL or SLL)
Interventions: DRUG: milatuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a Monoclonal Antibody KHK4083 in Moderate Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis|Digestive System Diseases|Colitis, Ulcerative|Colitis|Gastrointestinal Diseases|Inflammatory Bowel Diseases|Intestinal Diseases|Colonic Diseases|Autoimmune Disease|Abdominal Pain
Interventions: DRUG: KHK4083|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Insulin Resistance in Pulmonary Arterial Hypertension
Status: TERMINATED
Conditions: Hypertension, Pulmonary
Interventions: DRUG: bosentan|DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Probiotics vs Activated Charcoal in the Management of CKD Patients Suffering From Uremic Pruritus.
Status: NOT_YET_RECRUITING
Conditions: Chronic Kidney Disease|Uremic Pruritus
Interventions: DRUG: Probiotic Blend Capsule|DRUG: Activated Charcoal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Window-Of-Opportunity Study of the Anti-PD-1 Antibody Pembrolizumab in Patients With Resectable Malignant Pleural Mesothelioma
Status: TERMINATED
Conditions: Pleural Mesothelioma
Interventions: DRUG: Pembrolizumab|DRUG: Cisplatin and Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Magnetic Resonance Imaging With Ferumoxytol in Treating Patients With Non-small Cell Lung Cancer and Brain Metastases
Status: TERMINATED
Conditions: Lung Carcinoma Metastatic in the Brain|Stage IV Lung Non-Small Cell Cancer AJCC v7
Interventions: DRUG: Ferumoxytol|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of SYSA1801 in the Treatment of Claudin( CLDN) 18.2 Positive Advanced Malignant Solid Tumor
Status: UNKNOWN
Conditions: Advanced Solid Tumor|Gastric Cancer (GC)|Gastroesophageal Junction (GEJ) Cancer|Pancreatic Cancer
Interventions: DRUG: SYSA1801 for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-intensity Shockwaves Therapy + Tadalafil 5mg for the Treatment of Severe Erectile Dysfunction
Status: UNKNOWN
Conditions: Erectile Dysfunction
Interventions: OTHER: Dornier Aries2 LiST Device + 5mg Tadalafil (1)|OTHER: Dornier Aries2 LiST Device + 5mg Tadalafil (2)|OTHER: Sham LiST Device + 5mg Tadalafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Suprapubic Aspiration Versus Urinary Catheterization In Neonates.
Status: TERMINATED
Conditions: Neonatal Urinary Tract Infection
Interventions: PROCEDURE: Suprapubic Aspiration|PROCEDURE: Urinary Catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC