pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Phase 2 Trial of Rituximab and Corticosteroid Therapy for Newly Diagnosed Chronic Graft Versus Host Disease
Status: COMPLETED
Conditions: Graft vs Host Disease
Interventions: DRUG: Rituximab|DRUG: Prednisone|DRUG: Cyclosporine A|DRUG: tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Puncture and Program of Lifestyle Modification in Lupus Females
Status: UNKNOWN
Conditions: Systemic Lupus Erythematosus
Interventions: BEHAVIORAL: laser puncture, energy expenditure programming, and low-calories recommended diet programming|BEHAVIORAL: energy expenditure programming and low-calories recommended diet programming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Assessment of an Attenuated Live Listeria Vaccine in CIN 2+
Status: TERMINATED
Conditions: Cervical Intraepithelial Neoplasia
Interventions: BIOLOGICAL: ADXS11-001 (Lm-LLO-E7)|DRUG: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Benefits of Robotic and Laparoscopic Surgery for Mid and Low Rectal Cancer in Patients: The Charlson Comorbidity Index (CCI)
Status: COMPLETED
Conditions: Robotic|Laparoscopic|Anterior Resection for Rectal Cancer
Interventions: PROCEDURE: robotic surgery|PROCEDURE: laparoscopic surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Indole-3-Carbinol in Preventing Breast Cancer in Nonsmoking Women Who Are at High Risk For Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Indole-3-carbinol|DRUG: Indole-3-carbinol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Improved Accessibility of EmONC Services for Maternal and Newborn Health: a Community Based Project
Status: COMPLETED
Conditions: Sepsis|Pneumonia|Omphalitis|Birth Asphyxia|Respiratory Distress Syndrome|Eclampsia|Postpartum Hemorrhage|Puerperal Sepsis
Interventions: BEHAVIORAL: EmONC package
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Infliximab for Treatment of Immune Checkpoint Inhibitor Colitis
Status: RECRUITING
Conditions: Melanoma Stage III|Melanoma Stage IV|Skin Cancer Stage III|Skin Cancer Stage IV|Drug-Induced Colitis|Drug Toxicity|Immune-related Adverse Event
Interventions: DRUG: Infliximab|DRUG: Methylprednisolone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CP-751871 In Treating Women With Early-Stage Breast Cancer That Can Be Removed By Surgery
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: BIOLOGICAL: figitumumab|OTHER: imaging biomarker analysis|OTHER: laboratory biomarker analysis|OTHER: pharmacological study|PROCEDURE: conventional surgery|PROCEDURE: magnetic resonance spectroscopic imaging|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Escalation Study to Evaluate the Safety and Immunogenicity of MTBVAC Vaccine in Comparison With BCG Vaccine.
Status: COMPLETED
Conditions: Tuberculosis|Healthy
Interventions: BIOLOGICAL: MTBVAC live vaccine|BIOLOGICAL: Commercially available BCG live vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Microcurrents Therapy in Overactive Bladder.
Status: COMPLETED
Conditions: Overactive Bladder|Urinary Incontinence
Interventions: DEVICE: Microcurrents|DEVICE: Placebo Microcurrents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Initial Chronic Human Validation Study: Subcutaneous Implantable Cardioverter Defibrillator (S-ICD) System
Status: COMPLETED
Conditions: Ventricular Tachyarrhythmias
Interventions: DEVICE: Subcutaneous Implantable Defibrillator (S-ICD) System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study to Evaluate the Drug-drug Interaction Between Telmisartan, Amlodipine and Hydrochlorothiazide
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Telmisartan 80mg|DRUG: Amlodipine10mg|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3, Comparative Study of Asunaprevir and Daclatasvir Combination Therapy Versus Telaprevir Therapy in Japanese HCV Subjects
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: Daclatasvir|DRUG: Asunaprevir|DRUG: Ribavirin|BIOLOGICAL: pegIFNα-2b|DRUG: Telaprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gene-by-Stress Interactions in Intervention Studies Significance
Status: TERMINATED
Conditions: Cardiovascular Diseases
Interventions: DRUG: Ziprasidone|DRUG: Lorcaserin|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Irinotecan Plus E7820 Versus FOLFIRI in Second-Line Therapy in Patients With Locally Advanced or Metastatic Colon or Rectal Cancer
Status: TERMINATED
Conditions: Colon Cancer|Rectal Cancer
Interventions: DRUG: FOLFIRI|DRUG: E7820
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess Safety, Tolerability and Pharmacodynamics of Intravenous MEDI8111 After Single Ascending Doses.
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: MEDI8111|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Avastin (Bevacizumab) in Patients With Inflammatory or Locally Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: 5-fluorouracil|DRUG: Epidoxorubicin|DRUG: Cyclophosphamide|DRUG: Paclitaxel|BIOLOGICAL: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MLCT Oil for Fatty Liver - PASS Trial
Status: UNKNOWN
Conditions: Non-Alcoholic Fatty Liver Disease|Non-Alcoholic Steatohepatitis|NAFLD
Interventions: DIETARY_SUPPLEMENT: MLCT Oil|DIETARY_SUPPLEMENT: LCT Oil (Corn Oil)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Trial of a One-day CBT Workshop ("DISCOVER") for 15-18 Year Olds With Anxiety and/or Depression in Clinics
Status: COMPLETED
Conditions: Anxiety|Depression
Interventions: OTHER: One-day CBT workshop|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Randomized Study To Evaluate The Efficacy And Safety Of An Investigational Drug In Adolescent And Adult Subjects With Persistent Asthma.
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: GW685698X 200mcg,GW685698X 200mcg and 400mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Post-market Clinical Investigation of the SING IMT System, Model NG SI IMT 3X in Patients With End-stage Age-related Macular Degeneration
Status: RECRUITING
Conditions: AMD|Age-Related Macular Degeneration
Interventions: DEVICE: SING IMT(TM) System, model NG SI IMT 3X
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: An Updated Wearable Magnetic Flux Device to Optimize Blood Pressure Control
Status: RECRUITING
Conditions: Hypertension
Interventions: DEVICE: Wearable BP device|DEVICE: 24-hour ambulatory blood pressure monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Screening for Hesitancy to Optimize Talk
Status: COMPLETED
Conditions: Preventive Health Services
Interventions: BEHAVIORAL: Intervention Survey|BEHAVIORAL: Placebo Survey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety, PK, PD, and Antitumor Activity of Vecabrutinib (SNS-062) in B Lymphoid Cancers
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|Lymphoplasmacytoid Lymphoma|Mantle-Cell Lymphoma|Waldenstrom Macroglobulinemia|Diffuse Large B Cell Lymphoma|Follicular Lymphoma|Marginal Zone Lymphoma
Interventions: DRUG: SNS-062
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carbon Dioxide Insufflation on Cerebral Microemboli
Status: TERMINATED
Conditions: Cardiovascular Disease|Mitral Valve Repair|Cerebral Microemboli|Cognitive Decline
Interventions: PROCEDURE: Carbon dioxide insufflation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Periodontal Therapy on Glycemic Control in Diabetic Patients
Status: COMPLETED
Conditions: Chronic Periodontitis, Generalized
Interventions: COMBINATION_PRODUCT: amoxicillin 500mg and metronidazole 400mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Assessing GW870086's Potential to Cause Skin Thinning
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: GW870086 0.2%|DRUG: GW870086 2%|DRUG: Clobetasol Propionate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Prevention of Unexplained Recurrent Abortion by Enoxaparine
Status: TERMINATED
Conditions: Alive and Viable Births
Interventions: DRUG: enoxaparine 40 mg daily|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing Validity of M-Mode Time-to-Turbulence "T2T" Echo Use to Confirm CVC Tip Position
Status: UNKNOWN
Conditions: Central Venous Cather Position
Interventions: DEVICE: Echocardiography|DEVICE: CVC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase Angle and Body Composition, Inflammatory and Oxidative Stress Biomarkers.
Status: COMPLETED
Conditions: Body Composition, Beneficial|Oxidative Stress|Acute and Chronic Inflammation
Interventions: OTHER: Resistance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Platelet REACtivity According to TICagrelor Dose After Transcatheter AorticValve Implantation
Status: COMPLETED
Conditions: Symptomatic Aortic Stenosis
Interventions: DRUG: Ticagrelor 60mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Docetaxel +/- OGX-427 in Patients With Relapsed or Refractory Metastatic Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer|Urothelial Carcinoma
Interventions: DRUG: OGX-427|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Efficacy and Safety of Two Different Dose Regimens of Risankizumab Administered Subcutaneously in Japanese Subjects With Generalized Pustular Psoriasis or Erythrodermic Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: risankizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2
Status: ACTIVE_NOT_RECRUITING
Conditions: Corticobasal Degeneration (CBD)|Corticobasal Syndrome (CBS)|Cortical-basal Ganglionic Degeneration (CBGD)|Progressive Supranuclear Palsy (PSP)|Nonfluent Variant Primary Progressive Aphasia (nfvPPA)|Oligosymptomatic/Variant Progressive Supranuclear Palsy (o/vPSP)
Interventions: OTHER: Observational Study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Goserelin in Preventing Early Menopause in Premenopausal Women Undergoing Chemotherapy for Stage I, Stage II, or Stage III Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Infertility|Menopausal Symptoms
Interventions: DRUG: cyclophosphamide|DRUG: goserelin acetate|PROCEDURE: adjuvant therapy|PROCEDURE: fertility assessment and management|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Smoking Cessation Coaching in High-Risk Situations: A Virtual Reality Study
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Lapse prevention dialog: Boost motivation and self-efficacy|BEHAVIORAL: Lapse prevention dialog: Future-selves and implementation intentions|BEHAVIORAL: Lapse prevention dialog: Identity-related positive self-talk|BEHAVIORAL: Attention control dialog: neutral topic
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: AltaValve Pivotal Trial
Status: NOT_YET_RECRUITING
Conditions: Mitral Regurgitation|Mitral Insufficiency|Mitral Valve Incompetence|Mitral Valve Regurgitation|Mitral Incompetence
Interventions: DEVICE: AltaValve System.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Co-incubation of Oocytes With Sperm: Defining the Optimal Incubation Time
Status: COMPLETED
Conditions: Infertility
Interventions: OTHER: 2h exposure to sperm for IVF|OTHER: overnight exposure to sperm for IVF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stability and Crestal Bone Changes Around Implants Placed at Crestal Versus Subcrestal Level in Controlled Type Two Diabetic Patients
Status: COMPLETED
Conditions: Dental Implant|Diabetes
Interventions: PROCEDURE: Implants placed at bone crest|PROCEDURE: Implants placed 1mm Subcrestally
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Platelet Aggregability in Patients With Previous Acute Myocardial Infarction or Concomitant Lower Extremity Peripheral Artery Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease|Peripheral Arterial Disease
Interventions: DRUG: Clopidogrel
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Prospective Registry of Pediatric Cellular Therapy Patients at Risk for Endothelial Dysfunction, Sinusoidal Obstruction Syndrome and/or Multi-Organ Dysfunction Syndrome (MODS).
Status: RECRUITING
Conditions: Hematopoietic Cell Transplantation
Interventions: OTHER: Biorepository Trial
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Analgesic Activity of a Topical Formulation in Patients With Osteoarthritis of the Hands
Status: UNKNOWN
Conditions: Osteoarthritis of the Hands
Interventions: DRUG: A/B|DRUG: Placebo|DRUG: B/A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study in Phytotherapy of an Association of Plants in the Improvement of Psychological Well-being
Status: RECRUITING
Conditions: Psychological Well-being
Interventions: DIETARY_SUPPLEMENT: Dietary supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of Peripheral Nerve Stimulation for Acute Treatment of Migraine Pain
Status: COMPLETED
Conditions: Episodic Migraine
Interventions: DEVICE: Sham Treatment Location|DEVICE: Verum Treatment Location
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial of PM02734 Administered in Combination With Erlotinib in Patients With Advanced Malignant Solid Tumors
Status: COMPLETED
Conditions: Advanced Malignant Solid Tumors
Interventions: DRUG: PM02734 and erlotinib|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Neurocognitive Therapeutic Exercise in the Shoulder Impingement Syndrome in Comparison With Traditional Therapeutic Exercise
Status: COMPLETED
Conditions: Shoulder Impingement Syndrome
Interventions: OTHER: Neurocognitive therapeutic exercise|OTHER: Traditional therapeutic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Finding, Safety, Pharmacodynamic Effect Study of Sodium Nitrite Inhalation Solution in Normal, Healthy Volunteers
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Sodium Nitrite Inhalation Solution|DRUG: Placebo and AIR001 Inhalation Solution (Expansion arm)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of GlcNAc on Tear Production in NGLY1-CDDG
Status: NOT_YET_RECRUITING
Conditions: NGLY1 Deficiency
Interventions: DRUG: GlcNAc-GlcN|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Propranolol for Treating Fibromyalgia Pain
Status: TERMINATED
Conditions: Fibromyalgia Pain
Interventions: DRUG: Propranolol 1|DRUG: Propranolol 2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The LEARNING WISDOM Phase II Scale up Project
Status: UNKNOWN
Conditions: Transition|Emergencies|Health Care Utilization|Frailty
Interventions: BEHAVIORAL: GEM nurse|BEHAVIORAL: pre- and post-hospitalization medication list reconciliation|BEHAVIORAL: systematic discharge summaries|BEHAVIORAL: medical follow-up appointment|BEHAVIORAL: follow-up phone call|OTHER: Wiki-based Knowledge tools|OTHER: Telemonitoring service
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety Study of 3 mg/mL Baclofen Injection (Intrathecal) Using A Programmable Pump
Status: COMPLETED
Conditions: Severe Spasticity
Interventions: DRUG: Gablofen® 3 mg/mL (baclofen injection)|DEVICE: SynchroMed® II Programmable Pump
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treadmill and Music Cueing for Gait Training in Mild to Moderate Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: OTHER: Music and treadmill walking program|OTHER: Treadmill walking program|OTHER: Home program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Avatar-Directed Chemotherapy in Treating Patients With Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
Status: COMPLETED
Conditions: Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Gemcitabine Hydrochloride|DRUG: Paclitaxel|DRUG: Pegylated Liposomal Doxorubicin Hydrochloride|DRUG: Topotecan Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes in Real-life After Initation of Treatment With Trixeo (Budesonide / Glycopyrronium / Formoterol)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: BGF (budesonide/glycopyrrolate/formoterol fumarate)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lowering Events in Non-proliferative Retinopathy in Scotland
Status: COMPLETED
Conditions: Diabetic Retinopathy
Interventions: DRUG: Fenofibrate 145 mg|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous vs Oral Lansoprazole on Gastric Acid Secretion in Subjects With Erosive Esophagitis
Status: COMPLETED
Conditions: Esophagitis|Reflux
Interventions: DRUG: Lansoprazole|DRUG: Lansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Carbon Nanoparticles in Laparoscopic Colorectal Surgery
Status: UNKNOWN
Conditions: Colorectal Tumor
Interventions: PROCEDURE: Device: tumor localization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Soy Isoflavones on Skin Ageing Parameters
Status: COMPLETED
Conditions: Skin Ageing
Interventions: DIETARY_SUPPLEMENT: soy isoflavones|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Oral Abuse Potential of PF614 in Non-Dependent Recreational Opioid Users
Status: COMPLETED
Conditions: Recreational Drug Use
Interventions: DRUG: PF614|DRUG: Oxycodone Hydrochloride 40 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Healthy Approach to weIght Management and Food in Eating Disorders (HAPIFED)
Status: COMPLETED
Conditions: Binge Eating Disorder|Bulimia Nervosa|Eating Disorder
Interventions: BEHAVIORAL: HAPIFED|BEHAVIORAL: CBT-E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Open-label, Randomized Controlled, Multicenter Clinical Study of Haplo-HSCT Using a TBI or TMLI Conditioning Regimen for Pediatric ALL
Status: NOT_YET_RECRUITING
Conditions: Acute Lymphoblastic Leukemia, Pediatric
Interventions: RADIATION: TMLI|RADIATION: TBI|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Evaluation of Non-Invasive Vagus Nerve Stimulation for Temper Outbursts in People With PWS
Status: RECRUITING
Conditions: Prader-Willi Syndrome
Interventions: DEVICE: tVNS, intermittent stimulation|DEVICE: tVNS, continuous stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Splinting, Exercise and Electrotherapy on Hallux Valgus
Status: COMPLETED
Conditions: Hallux Valgus
Interventions: DEVICE: hallux valgus night splint|OTHER: exercise|OTHER: Electrotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety and Efficacy of the GMCN-508A Drug Product in Transfusion-dependent α-Thalassemia Participants
Status: RECRUITING
Conditions: Transfusion-dependent α-Thalassemia
Interventions: GENETIC: GMCN-508A Drug Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xpert Active Case-finding Trial 2: Community-based Active Case-finding for Tuberculosis in South Africa
Status: COMPLETED
Conditions: Tuberculosis
Interventions: OTHER: GeneXpert MTB/RIF|OTHER: Smear microscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: High-volume Versus Standard Volume Plasma Exchange in Patients With Acute Liver Failure With Cerebral Edema
Status: NOT_YET_RECRUITING
Conditions: Acute Liver Failure|Cerebral Edema
Interventions: PROCEDURE: High Volume Therapeutic Plasma Exchange compared to standard volume therapeutic plasma exchange
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Virtual Reality Application on Pain and Anxiety Level in Stone Crushing With Shock Waves: A Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Shockwave Lithotripsy|Pain|Anxiety|Virtual Reality|Nursing
Interventions: DEVICE: virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of a Stress Reduction and Lifestyle Modification Programme on the Quality of Life of Crohn's Disease Patients
Status: COMPLETED
Conditions: Crohn Disease
Interventions: BEHAVIORAL: lifestyle-modification|BEHAVIORAL: waiting control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Heart Rate Limitation on Exercise Tolerance in Pacemaker Patients.
Status: COMPLETED
Conditions: Chronic Heart Failure|Atrial Fibrillation|Arrhythmia, Sinus
Interventions: DRUG: Ivabradine|OTHER: Atrial fibrillation|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Tranexamic Acid Plus Perivascular Vasopressin at the Time of Abdominal Myomectomy
Status: UNKNOWN
Conditions: Myoma
Interventions: DRUG: Topical TA|DRUG: vasopressin|OTHER: placebo to TA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pressure HIgh or LOw DElivered to Preterm Newborns in the Delivery ROOM
Status: RECRUITING
Conditions: Respiratory Distress Syndrome in Premature Infant
Interventions: BEHAVIORAL: static CPAP 8 cmH2O|BEHAVIORAL: static CPAP 5 cmH2O
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Does Omega-3 Polyunsaturated Fatty Acids (PUFAs) Pretreatment Improve Outcomes in Patients Undergoing Percutaneous Coronary Intervention (PCI)?
Status: UNKNOWN
Conditions: Coronary Arteriosclerosis
Interventions: DRUG: omega 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rate of Atrial Fibrillation Through 12 Months in Patients With Recent Ischemic Stroke of Presumed Known Origin
Status: COMPLETED
Conditions: Stroke, Acute
Interventions: DEVICE: Reveal LINQ™ Insertable Cardiac Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Study of the NIDEK TONOREF III With Predicate Devices
Status: RECRUITING
Conditions: Intraocular Pressure
Interventions: DEVICE: NIDEK TONOREF III|DEVICE: Haag-Streit, PERKINS HAND-HELD APPLANATION TONOMETER|DEVICE: NIDEK CEM-530
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Long-term Safety and Efficacy of Ferriprox® in Iron Overloaded Patients With Sickle Cell Disease or Other Anemias
Status: TERMINATED
Conditions: Iron Overload|Sickle Cell Disease|Other Anemias
Interventions: DRUG: Deferiprone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addressing Nonsuicidal Self-injury in Schools
Status: COMPLETED
Conditions: Nonsuicidal Self-injury|Suicidal Ideation|Stigmatization|Help-Seeking Behavior|Perceived Social Support|Mental Well-being
Interventions: BEHAVIORAL: Addressing NSSI in schools|OTHER: Control condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies.
Status: RECRUITING
Conditions: CLL/SLL|Waldenstrom Macroglobulinemia|Follicular Lymphoma|Diffuse Large B Cell Lymphoma|Mantle Cell Lymphoma|Marginal Zone Lymphoma|Hairy Cell Leukemia
Interventions: DRUG: LP-168|DRUG: LP-168
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extension to Viral Kinetics Study of Telbivudine and Entecavir in Adults With Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: telbivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Daratumumab, Carfilzomib, Lenalidomide and Low Dose Dexamethasone (DKRd) in Newly Diagnosed, Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Myeloma|Multiple Myeloma
Interventions: DRUG: Daratumumab|DRUG: Carfilzomib|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: H5N1 Mix and Match With MF59
Status: COMPLETED
Conditions: Influenza
Interventions: OTHER: Phosphate Buffered Saline (PBS) diluent|DRUG: MF59 Adjuvant|BIOLOGICAL: H5N1 Antigen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Sternal Closure With STERNUMFIX in Patients With High Risk
Status: TERMINATED
Conditions: Sternum Wound Infection|Nonunion of Fracture of Sternum
Interventions: DEVICE: Sternumfix|PROCEDURE: steel wire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prospective Pilot Study of Pre-Transplant Thymoglobulin Administration in Living Donor Renal Transplant Recipients
Status: COMPLETED
Conditions: Renal Transplant Rejection|Transplants and Implants
Interventions: DRUG: Thymoglobulin|DRUG: Thymoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients
Status: RECRUITING
Conditions: Atrial Fibrillation|Heart Failure
Interventions: DEVICE: ASSERT Insertable Cardiac Monitor|OTHER: Conventional Management and monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Barbed vs Standard Suture for Laparoscopic Vaginal Cuff Closure
Status: COMPLETED
Conditions: Gynecologic Surgical Procedures
Interventions: OTHER: 2/0 barbed suture|OTHER: 0/0 Vicryl suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sealing Defective Margins of Composite Restorations With Fluid Composite Resin Nanofiller Reinforced
Status: COMPLETED
Conditions: Dental Caries|Minimally Invasive|Repair
Interventions: PROCEDURE: Sealing margins with flow composite|PROCEDURE: Sealing margins with seal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Respiratory Yoga Training on Heart Rate Variability and Baroreflex of Healthy Elderly Subjects
Status: COMPLETED
Conditions: Elderly Subjects|Respiration Exercises
Interventions: OTHER: Stretching Exercises|OTHER: Respiratory Exercises conducted twice a day for 10 minutes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Consecutive Strength- and Endurance Regimes on the Myonuclear Domain and Satellite Cell in the M. Vastus Lateralis of Old Healthy Men
Status: COMPLETED
Conditions: Regeneration Potential of Healthy Old Men in Terms of Satellite Cell Activation
Interventions: PROCEDURE: Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: The Use of Drugs to Improve Kidney Function in Patients With Liver and Kidney Dysfunction
Status: COMPLETED
Conditions: Type 2 Hepatorenal Syndrome|Refractory Ascites
Interventions: DRUG: Midodrine, albumin, octreotide LAR|DRUG: midodrine, octreotide, albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Level of Hand Fatigability on Multiple Sclerosis on General Fatigue and Functionality
Status: COMPLETED
Conditions: Fatigue|Functionality|Multiple Sclerosis|Dexterity
Interventions: DIAGNOSTIC_TEST: Nine-Hole Peg Test (NHPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome
Status: COMPLETED
Conditions: Noonan Syndrome
Interventions: DRUG: Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Response AMP Challenge Study With Beclometasone Dipropionate (BDP)/Formoterol Pressurised Metered Dose Inhaler (pMDI)
Status: COMPLETED
Conditions: Mild Persistent Asthma
Interventions: DRUG: BDP/formoterol|DRUG: BDP/formoterol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Selinexor & Talazoparib in Advanced Refractory Solid Tumors; Advanced/Metastatic Triple Negative Breast Cancer (START)
Status: RECRUITING
Conditions: Advanced Refractory Solid Tumors|Advanced Triple Negative Breast Cancers|Metastatic Triple Negative Breast Cancers
Interventions: DRUG: Talazoparib|DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation|OTHER: Aerobic Exercise|DRUG: Acetylcholinesterase Inhibitors|DRUG: Memantine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide With or Without Rituximab After Standard Chemotherapy in Treating Patients With Diffuse Large B-Cell Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Lenalidomide|DRUG: Lenalidomide|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of the Efficacy and Toxicity of Ontak(Registered Trademark) (Denileukin Diftitox) in the Therapy of Adult T-Cell Leukemia
Status: TERMINATED
Conditions: Leukemia, Adult T-Cell
Interventions: BIOLOGICAL: Denileukin diftitox (Ontak)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeting Metabolic Flexibility in Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis|Motor Neuron Disease
Interventions: DRUG: Trimetazidine Dihydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SAD/MAD Study to Assess Safety, Tolerability, PK & PD of MEDI1814 in Subjects With Mild-Moderate Alzheimer's Disease.
Status: COMPLETED
Conditions: Mild-Moderate Alzheimer's Disease|Healthy Elderly
Interventions: BIOLOGICAL: MEDI1814 for IV injection|BIOLOGICAL: MEDI1814 for Subcutaneous Injection|BIOLOGICAL: IV Placebo|BIOLOGICAL: Placebo for Subcutaneous Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Orally Administered Laquinimod Versus Placebo for Treatment of Relapsing Remitting Multiple Sclerosis (RRMS)
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Laquinimod|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Outcomes for Prontosan Versus Normal Saline for Negative Pressure Wound Therapy With Instillation
Status: COMPLETED
Conditions: Wound Infection
Interventions: DRUG: Normal saline|DEVICE: Prontosan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Pharmacokinetics and Safety of Carfilzomib in Patients With Advanced Malignancies and Hepatic Impairment
Status: COMPLETED
Conditions: Solid Tumors|Hematologic Malignancies|Hepatic Impairment
Interventions: DRUG: Carfilzomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Text Message Behavioral Intervention to Reduce Alcohol Consumption in Young Adults
Status: COMPLETED
Conditions: Alcohol Consumption|Alcohol Intoxication
Interventions: BEHAVIORAL: SMS Assessments & Feedback|BEHAVIORAL: SMS Assessments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Skin Hydration in Adults With Dry Skin Using a Moisturizer With an Added Sterilized Probiotic
Status: ACTIVE_NOT_RECRUITING
Conditions: Dry Skin
Interventions: OTHER: Sterilized probiotic LfQi601|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Motivational Interviewing-Based Breastfeeding Education
Status: COMPLETED
Conditions: Breastfeeding|Motivation|Success|Self-Efficacy
Interventions: OTHER: Motivational Interviewing-Based Breastfeeding Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase III Study of Apatinib Tablets in the Treatment of Advanced or Metastatic Gastric Cancer
Status: COMPLETED
Conditions: Advanced or Metastatic Gastric Cancer
Interventions: DRUG: apatinib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation and Cohort Expansion Study of NKTR-214 in Combination With Nivolumab and Other Anti-Cancer Therapies in Patients With Select Advanced Solid Tumors
Status: COMPLETED
Conditions: Melanoma|Renal Cell Carcinoma|Non Small Cell Lung Cancer|Urothelial Carcinoma|Triple Negative Breast Cancer|HR+/HER2- Breast Cancer|Gastric Cancer
Interventions: DRUG: Dose Escalation Doublet: Combination of NKTR-214 + nivolumab|DRUG: Dose Expansion Doublet: Combination of NKTR-214 + nivolumab|DRUG: Schedule Finding Triplet: Combination of NKTR-214+ nivolumab+ ipilimumab|DRUG: Dose Expansion Triplet: Combination of NKTR-214+ nivolumab+ ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulsed vs Continuous Radiofrequency Neurotomy for Cervical Facet Joint Mediated Pain
Status: RECRUITING
Conditions: Faceto-genic Neck Pain|Shoulder Pain Chronic|Faceto-genic Headache
Interventions: PROCEDURE: Pulsed Radiofrequency Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Radiological Impact of Tibial Cutting Int Total Knee Arthroplasty, Accelerated Navigation Versus Extramedullary Targeting
Status: UNKNOWN
Conditions: Gonarthrosis
Interventions: PROCEDURE: First line total knee replacement for gonarthrosis .
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Bioequivalence Study of Olaparib Tablets Under Fasting and Fed Conditions in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Olaparib Tablet test formulation 100mg|DRUG: Olaparib Tablet reference formulation 100mg|DRUG: Olaparib Tablet test formulation 150mg|DRUG: Olaparib Tablet reference formulation 150mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study With Adjunctive Once Daily Topical Nepafenac 0.3% Versus Placebo
Status: COMPLETED
Conditions: Cystoid Macular Edema
Interventions: DRUG: Nepafenac 0.3%|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open-label Study of Midazolam Hydrochloride Oromucosal Solution (MHOS/SHP615) in Children With Status Epilepticus (Convulsive) in a Healthcare Setting in Japan
Status: COMPLETED
Conditions: Nervous System Diseases
Interventions: DRUG: SHP615
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Automated Versus Manual Fluid Management for High Risk Abdominal Surgical Patient. A Prospective, Randomized Trial
Status: COMPLETED
Conditions: Major Abdominal Surgery|Colorectal Surgery|Hepatectomy|Pancreatectomy|Pancreaticoduodenectomy
Interventions: DEVICE: Closed loop automated System (LIR®: learning intravenous resuscitator)|DEVICE: manual current practice by anesthesiologist team
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Pharmacokinetics and Pharmacodynamics of JNJ-54452840 in Participants With Heart Failure and Anti-beta1-adrenergic Receptor Autoantibodies
Status: WITHDRAWN
Conditions: Heart Failure
Interventions: DRUG: JNJ-54452840|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Iodine-131 Anti-B1 Antibody Plus CHOP For Untreated Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Iodine-131 Anti-B1 Antibody|DRUG: Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-Blind, Trial to Evaluate the Safety and Efficacy of MRX-6 Cream 2%
Status: TERMINATED
Conditions: Atopic Dermatitis
Interventions: DRUG: MRX-6|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Research Study of Inebilizumab in Neuromyelitis Optica Spectrum Disorders
Status: NOT_YET_RECRUITING
Conditions: Neuromyelitis Optica Spectrum Disorders
Interventions: DRUG: Inebilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IRIS Followed by mFOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer
Status: SUSPENDED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Campto, Topotesin|DRUG: TS-1|DRUG: L-Plat|DRUG: Isovorin|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative User Experiences With BD Nano™ PRO 32G Extra Thin Wall Pen Needle vs the Terumo Nanopass® 34G Pen Needle
Status: COMPLETED
Conditions: Diabetes
Interventions: DEVICE: Terumo Nanopass® 34G pen needle|DEVICE: BD Nano™ PRO 32G pen needle
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER