pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Nitrite, Isoquercetin and Endothelial Dysfunction (NICE) Trial
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Immediate release sodium nitrite|DIETARY_SUPPLEMENT: Isoquercetin|OTHER: placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trunk Control, Balance, Gait, Functional Mobility and Fear of Falling in People With Alzheimer's Disease
Status: COMPLETED
Conditions: Physical Therapy
Interventions: OTHER: Balance|OTHER: Trunk control|OTHER: Gait|OTHER: Functional mobility|OTHER: Fear of falling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: High-Dose Chemotherapy Plus Autologous Stem Cell Transplantation Compared With Intermediate-Dose Chemotherapy Plus Autologous Stem Cell Transplantation With or Without Isotretinoin in Treating Young Patients With Recurrent High-Grade Gliomas
Status: COMPLETED
Conditions: Brain Tumor|Central Nervous System Tumor
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: etoposide|DRUG: isotretinoin|DRUG: thiotepa|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feeding Progression in Preterm Infants
Status: COMPLETED
Conditions: Infant, Premature, Diseases|Feeding Behavior|Feeding Patterns
Interventions: OTHER: q6 hour oral feeding schedule|OTHER: q3 hour oral feeding schedule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Preoperative Walking Exercises on the Prognosis of Supratentorial Brain Tumours Patients After Craniotomy
Status: NOT_YET_RECRUITING
Conditions: Supratentorial Brain Tumor|Exercise|Cognition|Postoperative Complications
Interventions: BEHAVIORAL: Walking exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Raltegravir One Thousand Two Hundred vs Darunavir-cb in Immnunosupressed Patients: ROTDIP Study
Status: UNKNOWN
Conditions: HIV Infections
Interventions: DRUG: Experimental: RAL QD|DRUG: Active comparator: DRV/cb
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FES to Improve Gait in CP
Status: TERMINATED
Conditions: Cerebral Palsy|Spastic Diplegia Cerebral Palsy|Gait
Interventions: OTHER: Functional Electrical Stimulation protocol|OTHER: Treadmill only protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sinuclean Nebules 45 for Treatment of Pediatric Exudative Otitis Media
Status: COMPLETED
Conditions: Otitis Media With Effusion
Interventions: DEVICE: Sinuclean Nebules 45|OTHER: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Genistein in Pediatric Oncology Patients (UVA-Gen001)
Status: TERMINATED
Conditions: Lymphoma|Childhood Lymphoma|Solid Tumor|Childhood Solid Tumor|Neuroblastoma|Ewing Sarcoma|Hodgkin Lymphoma|Non-Hodgkin Lymphoma|Rhabdomyosarcoma|Soft Tissue Sarcoma|Medulloblastoma|Germ Cell Tumor|Wilms Tumor|Brain Neoplasms|Medulloblastoma, Childhood|Neuroectodermal Tumors, Primitive
Interventions: DRUG: Genistein|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Theta-Burst Stimulation for Bipolar Depression
Status: RECRUITING
Conditions: Bipolar Depression|Bipolar Disorder|Treatment- Resistant Bipolar Disorder|Type 2 Bipolar Disorder
Interventions: DEVICE: iTBS Stimulation|DEVICE: Sham iTBS Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determination of Genetic Susceptibility in Severe Recurrences of Ocular Toxoplasmosis
Status: TERMINATED
Conditions: Toxoplasmosis Infection|Genotype II|Ocular Toxoplasmosis With Recurrences
Interventions: BIOLOGICAL: seropositive for Toxoplasma gondii
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Early Detection of Neuropathy in ATTRv
Status: ACTIVE_NOT_RECRUITING
Conditions: Hereditary Amyloidosis, Transthyretin-Related
Interventions: DIAGNOSTIC_TEST: neurofilament light chain|DIAGNOSTIC_TEST: In-vivo Meissner Corpuscle imaging|DIAGNOSTIC_TEST: Nerve conduction study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Use of Gastrografin in Chronic Radiation Enteropathy With Small Bowel Obstruction
Status: UNKNOWN
Conditions: CRE-induced SBO
Interventions: DRUG: Gastrografin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ezetimibe and Simvastatin in Primary Hypercholesterolemia, Diabetes Mellitus Type 2, and Coronary Heart Disease (COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia|Diabetes Mellitus, Type 2|Coronary Disease
Interventions: DRUG: Ezetimibe 10 mg|DRUG: Simvastatin 20 mg|DRUG: Ezetimibe Placebo|DRUG: Simvastatin 20 mg|DRUG: Simvastatin Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Afatinib Plus Bevacizumab in the Treatment Epidermal Growth Factor Receptor (EGFR) Exon G719X, S768I, and L861Q Mutation Metastatic Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: PFS
Interventions: DRUG: afatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Re-mineralization Effects of Sugar Free Chewing Gum Sweetened With Different Sugar-substitutes
Status: COMPLETED
Conditions: Re-mineralization
Interventions: OTHER: maltitol|OTHER: xylitol|OTHER: gum base
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Graded Motor Imagery Training in Shoulder Impingement Syndrome
Status: COMPLETED
Conditions: Shoulder Impingement Syndrome|Pain
Interventions: OTHER: Graded Motor Imagery (GMI) training|OTHER: Conventional Physiotherapy|OTHER: Home Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Gastrointestinal And Metabolic Effects From a Prebiotic, Lifting, and Aerobic iNtervention
Status: RECRUITING
Conditions: Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: Fructooligosaccharides (FOS)|BEHAVIORAL: Exercise|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Evaluate the Effect of Liraglutide on Ambulatory Blood Pressure-A Pilot Study
Status: COMPLETED
Conditions: Diabetes Mellitus, Non-Insulin-Dependent|Hypertensive Disease
Interventions: DRUG: Liraglutide or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Simulated Conversation Training for Mental Healthcare Providers to Improve Care for Transgender and Gender Nonconforming Individuals
Status: UNKNOWN
Conditions: Gender Affirming Communication Skills
Interventions: OTHER: Computer based role play trianing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Antenatal Exercises With Sacroiliac Joint Mobilization in Pregnancy Related Pelvic Girdle Pain
Status: UNKNOWN
Conditions: Pregnancy Related Pelvic Girdle Pain
Interventions: PROCEDURE: Sacroiliac joint mobilization|PROCEDURE: Standard therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Evaluation of Decision Support Interventions for Atrial Fibrillation
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: OTHER: Patient Decision Aid|OTHER: Encounter Decision Aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Phase II Pharmacokinetic and Pharmacodynamic Study of DEX in Subjects Aged 12 Months Through <24 Months
Status: COMPLETED
Conditions: Sedation|Pain
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study on Safety and Effectiveness of Mesenchymal Stem Cell Exosomes for the Treatment of COVID-19.
Status: RECRUITING
Conditions: COVID-19 Pneumonia
Interventions: BIOLOGICAL: Extracellular Vesicles from Mesenchymal Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PET Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis
Status: COMPLETED
Conditions: Carotid Atherosclerosis
Interventions: DEVICE: Cu[64]-25%-CANF-Comb PET-MR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase 2 Study in Vascular Inflammation on Patients After an Acute Coronary Syndrome Event
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: VIA-2291|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer
Status: RECRUITING
Conditions: Brain Cancer|Glioblastoma|Metastatic Cancer|Leptomeningeal Metastasis|Recurrent Glioblastoma
Interventions: DRUG: Trastuzumab deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Ascending Dose Study to Characterize the Pharmacokinetics, Safety, and Tolerability of SAR441566 in Healthy Adult Japanese Male Participants.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: SAR441566
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gender Effects of Dietary Omega-3 Fatty Acids From Plant and Marine Sources on Oxylipins in Healthy Humans
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Flax Oil|DIETARY_SUPPLEMENT: Fish Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Temporal Interference and Depression
Status: NOT_YET_RECRUITING
Conditions: Major Depressive Disorder
Interventions: DEVICE: Temporal Interference stimulation|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Dietary Carbohydrate Content of Indian Diabetics With Special Therapeutic View on Effectiveness of Acarbose and Metformin Monotherapy
Status: WITHDRAWN
Conditions: Diabetes Mellitus
Interventions: DRUG: Bay G5421 Glucobay|DRUG: Metformin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate the Safety and Tolerability of CC-94676 in Participants With Metastatic Castration-Resistant Prostate Cancer
Status: RECRUITING
Conditions: Prostatic Neoplasms
Interventions: DRUG: CC-94676|DRUG: CC1083611|DRUG: CC1083610
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone, Flurbiprofen Axetil and Long-term Survival After Lung Cancer Surgery
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung|Surgery|Dexamethasone|Flubiprofen Axetil|Long-term Effects Secondary to Cancer Therapy in Adults
Interventions: DRUG: Dexamethasone|DRUG: Normal saline|DRUG: Flurbiprofen axetil|DRUG: Lipid microsphere
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Measure the Serum Level of Homocysteine in Acne Patients Before and After Oral Isotretinoin.
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Isotretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Imipramine and Pregabalin Combination in Painful Polyneuropathy
Status: UNKNOWN
Conditions: Polyneuropathy
Interventions: DRUG: Imipramine|DRUG: Pregabalin|DRUG: Imipramine, pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Mindfulness-Based Cognitive-Behavioral Conjoint Therapy on PTSD and Relationship Function
Status: COMPLETED
Conditions: PTSD
Interventions: BEHAVIORAL: Mindfulness Based Cognitive Behavioral Conjoint Therapy|BEHAVIORAL: CBCT for PTSD - Communication Skills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of AVE5530 as add-on to Ongoing High Doses of Statins in Patients With Primary Severe Hypercholesterolemia
Status: TERMINATED
Conditions: Hypercholesterolemia
Interventions: DRUG: AVE5530|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemo, Peripheral Stem Cell Transplant, Biological Therapy, Pamidronate and Thalidomide for Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: recombinant interferon alfa|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: melphalan|DRUG: pamidronate disodium|DRUG: thalidomide|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation in Axial Spondyloarthritis
Status: RECRUITING
Conditions: Axial Spondyloarthritis|Ankylosing Spondylitis|Dysbiosis|Spondyloarthritis|Spondylitis|Arthritis|Musculoskeletal Diseases|Spinal Disease|Joint Diseases
Interventions: DRUG: FMT|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Preventive Dexketoprofen Reduce Pain After Orthognathic Surgery
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: iv dexketoprofen trometamol (Arveles 50mg/2mL; UFSA, İstanbul, Turkey)|DRUG: Steril Salin (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Docetaxel for Injection (Albumin-bound) and SG001 in Combination With Cisplatin and Simultaneous Radiotherapy for Locally Advanced Unresectable Esophageal Squamous Carcinoma.
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Unresectable Esophageal Squamous Carcinoma
Interventions: DRUG: Docetaxel for Injection (Albumin-bound)|DRUG: SG001|DRUG: Cisplatin for injection|DRUG: Paclitaxel|RADIATION: Simultaneous Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation and Analysis of Fecal Microbiome in IBD Patients
Status: UNKNOWN
Conditions: Inflammatory Bowel Diseases
Interventions: PROCEDURE: Fecal microbiome transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3484356 in Healthy Female Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3484356|DRUG: Omeprazole|DRUG: Itraconazole|DRUG: Carbamazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Central Venous Catheter-Related Infection
Status: COMPLETED
Conditions: Critically Ill Patients|Infection
Interventions: DEVICE: Antimicrobial impregnated catheter (5593)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Nebivolol Effects on Endothelial Function and Erectile Function
Status: UNKNOWN
Conditions: Erectile Dysfunction
Interventions: DRUG: Nebivolol|DRUG: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Regional Versus General Anesthesia on Thirty-day Outcomes Following Carotid Endarterectomy: a Matched-pairs Cohort Study.
Status: COMPLETED
Conditions: Regional Anesthesia Morbidity|Carotid Artery Diseases|Perioperative/Postoperative Complications
Interventions: PROCEDURE: Anesthetic technique (regional versus general)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of Nicotinamide Adenine Dinucleotide (NAD) on Brain Function and Cognition
Status: COMPLETED
Conditions: Mild Cognitive Impairment|NAD
Interventions: DIETARY_SUPPLEMENT: Nicotinamide riboside|DIETARY_SUPPLEMENT: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Liquid Protein Preloads With Different Carbohydrate Types Effects on the Glycaemic and Insulinaemic Response
Status: COMPLETED
Conditions: Diabetes|Impaired Glucose Tolerance|Obesity
Interventions: DIETARY_SUPPLEMENT: Bread, Soy milk and cow milk|DEVICE: real-time ultrasonography (GE LOGIQ P5 ultrasound in CNRC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Botox in Obstructed Defecation Syndrome
Status: TERMINATED
Conditions: Obstructed Defecation Syndrome (ODS)
Interventions: DRUG: Botulinum Toxin-A|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of SHR-1210± SHR-1020 Versus Chemotherapy in Patients With Recurrent or Metastatic Cervical Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent or Metastatic Cervical Cancer
Interventions: DRUG: SHR-1210|DRUG: SHR-1020|DRUG: Physician's choice chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Long Term Effect of Low Dose Aspirin on Uric Acid in Chinese Patients With Coronary Artery Disease（AURORA）
Status: UNKNOWN
Conditions: Coronary Artery Disease|Hyperuricemia
Interventions: DRUG: Aspirin 100 mg|DRUG: Clopidogrel 75mg
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Establishing Efficacy of an Inpatient Intervention and Phone App to Reduce Suicidal Risk
Status: COMPLETED
Conditions: Suicidal Ideation|Suicide, Attempted
Interventions: BEHAVIORAL: ASAP (As Safe As Possible)|BEHAVIORAL: BRITE smart phone app|BEHAVIORAL: TAU (treatment as usual)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Effect of Multiple Oral Doses and Regimens of KD025 in Healthy Male and Post-menopausal Female Subjects
Status: COMPLETED
Conditions: Immune System Disorder (Healthy Volunteer)
Interventions: DRUG: Belumosudil mesylate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intracoronary Autologous Mesenchymal Stem Cells Implantation in Patients With Ischemic Dilated Cardiomyopathy
Status: UNKNOWN
Conditions: Ischemic Dilated Cardiomyopathy
Interventions: OTHER: BM-MSCs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pivotal Efficacy Trial to Evaluate HLD200 in Children With ADHD in a Naturalistic Setting
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: HLD200 methylphenidate hydrochloride (MPH) Capsules|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Sevoflurane on Extravascular Lung Water and Pulmonary Vascular Permeability in Patients With ARDS
Status: UNKNOWN
Conditions: ARDS|ARDS, Human
Interventions: DRUG: Sevoflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Hydrolysed Red Ginseng Extract on Improvement of Cognitive Function
Status: COMPLETED
Conditions: Cognitive Function
Interventions: DIETARY_SUPPLEMENT: Hydrolysed Red Ginseng Extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Efficacy and Safety of Lutathera in Patients With Grade 2 and Grade 3 Advanced GEP-NET
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastro-enteropancreatic Neuroendocrine Tumor
Interventions: DRUG: Lutathera|DRUG: long-acting octreotide|DRUG: high dose long-acting octreotide|OTHER: Optional post-progression re-treatment with Lutathera|OTHER: Optional post-progression cross-over to Lutathera|OTHER: Optional post-progression re-treatment with Lutathera after cross-over
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IDEAL SKIIN CARES Bundle to Prevent Pressure Injury
Status: NOT_YET_RECRUITING
Conditions: Pressure Ulcer|Pressure Injury|Bed Sore|Pressure Sore|Decubitus Sore|Decubitus Ulcer|Skin Ulcer
Interventions: OTHER: IDEAL SKIIN CARES bundles|OTHER: IDEAL SKIIN CARES bundles workshop|OTHER: Respiratory care workshop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: DEBIRI Combined With Chemotherapy and Bevacizumab in the Treatment of Unresectable Colorectal Cancer Liver Metastases
Status: NOT_YET_RECRUITING
Conditions: Colorectal Neoplasms
Interventions: COMBINATION_PRODUCT: DEBIRI Combined With Chemotherapy and Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Ferumoxytol for the Treatment of Iron Deficiency Anemia in Pediatric Participants With Nondialysis-Dependent Chronic Kidney Disease
Status: TERMINATED
Conditions: Iron Deficiency Anemia|Nondialysis-dependent Chronic Kidney Disease
Interventions: DRUG: Ferumoxytol|DRUG: Oral Iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STOPBANG As A Screening Tool for Obstructive Sleep Apnoea in Pregnancy
Status: COMPLETED
Conditions: Obstructive Sleep Apnoea|Pregnancy
Interventions: OTHER: STOPBANG Questionnaire|DIAGNOSTIC_TEST: Overnight pulse oximetry|OTHER: Epworth Sleepiness Scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Neoplasms, Brain|Glioblastoma Multiforme|Glioblastoma of Cerebellum|Neoplasms|Astrocytoma|Astrocytoma, Cerebellar|Neuroectodermal Tumors|Neuroectodermal Tumors, Primitive|Cerebellar PNET, Childhood|Cerebellar Neoplasms|Cerebellar Neoplasms, Primary|Cerebellar Neoplasm, Malignant|Cerebellar Neoplasm Malignant Primary|Neoplasm Metastases|Neoplasm Malignant|Neoplasms, Neuroepithelial|Neoplasms, Germ Cell and Embryonal|Neoplasms by Histologic Type|Neoplasms, Glandular and Epithelial|Neoplasms, Nerve Tissue|Central Nervous System Neoplasms, Primary|Central Nervous System Neoplasms, Malignant|Nervous System Neoplasms|Neoplasms by Site|Brain Diseases|Central Nervous System Diseases|Nervous System Diseases|Medulloblastoma Recurrent|HSV|Virus|Pediatric Brain Tumor|Nervous System Cancer|Primitive Neuroectodermal Tumor (PNET) of Cerebellum
Interventions: BIOLOGICAL: G207
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of LEO 43204 for Actinic Keratosis Applied on Face/Chest, Scalp and Trunk/Extremities, Respectively
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: LEO 43204
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Acting Phosphodiesterase 5 Inhibitors as Add-on Therapy for Patients With Pulmonary Hypertension Treated With Prostanoids.
Status: UNKNOWN
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Tadalafil|DRUG: Vardenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correlation Between Depression Scores and Serum NF-ĸB/NLRP3 Axis, Biotinidase, and HMGB After Treatment With Isotretinoin in Patients With Acne Vulgaris
Status: RECRUITING
Conditions: Acne Vulgaris
Interventions: DRUG: ISOtretinoin 20 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assess the Safety and Efficacy of CsA Ophthalmic Gel in Subjects With Moderate to Severe Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: CsA Ophthalmic Gel|DRUG: Placebo|DRUG: Hypromellose Eye Drop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multidisciplinary CAE and CABG Surgery to Optimize the Management of High-risk Patients During the Perioperative Period
Status: COMPLETED
Conditions: Carotid Endarterectomy|Coronary Artery Bypass Grafting
Interventions: PROCEDURE: carotid endarterectomy and coronary artery bypass grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of TQH3906 Capsules in Healthy Volunteers
Status: RECRUITING
Conditions: Psoriasis
Interventions: DRUG: TQH3906 capsule|DRUG: TQH3906 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ABT-888 and Temozolomide for Metastatic Breast Cancer and BRCA1/2 Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Metastatic Breast Cancer|BRCA1 Gene Mutation|brca2 Gene Mutation
Interventions: DRUG: ABT-888|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Stem Cell Transplantation With Adoptive Immunotherapy in Epstein-Barr Virus Positive Recurrent/Refractory Hodgkins Lymphoma
Status: TERMINATED
Conditions: Hodgkins Lymphoma
Interventions: BIOLOGICAL: allogeneic donor derived LMP specific cytotoxic T-lymphocyte
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Preliminary Activity of Idasanutlin in Combination With Either Chemotherapy or Venetoclax in Treatment of Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias or Solid Tumors
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)|Acute Lymphoblastic Leukemia (ALL)|Neuroblastoma|Solid Tumors
Interventions: DRUG: Idasanutlin|DRUG: Venetoclax|DRUG: Cyclophosphamide|DRUG: Topotecan|DRUG: Fludarabine|DRUG: Cytarabine|DRUG: Intrathecal Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Subcutaneous Gefurulimab Using Prefilled Syringe Versus Autoinjector in Healthy Adult Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Adult Participants
Interventions: DRUG: Gefurulimab PFS-SD|DRUG: Gefurulimab AI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ph1 Study of SL-172154 Administered Intratumorally in Subjects With Squamous Cell Carcinoma of the Head and Neck or Skin
Status: TERMINATED
Conditions: Cutaneous Squamous Cell Carcinoma|Squamous Cell Carcinoma of Head and Neck
Interventions: DRUG: Drug: SL-172154
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extended Therapy of Drotrecogin Alfa (Activated) 4 vs 7 Days Infusion
Status: COMPLETED
Conditions: Sepsis|Hypotension
Interventions: DRUG: Drotrecogin Alfa (Activated)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Circuitry Assessment and Reinforcement Training Effects on Recovery
Status: SUSPENDED
Conditions: Aphasia|Primary Progressive Aphasia|Stroke
Interventions: DEVICE: EEG Neurofeedback|DEVICE: Sham Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Vicinium for Treating Patients With Non-Invasive Urothelial Carcinoma In Situ
Status: COMPLETED
Conditions: Urinary Bladder Cancer|Bladder Cancer|Bladder Neoplasms|Bladder Tumors
Interventions: DRUG: Vicinium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic EVOZAC® Calming Skin Spray for EGFR-TKIs Associated Rash Eruption in NSCLC
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: OTHER: EVOZAC Calming Skin Spray|OTHER: Physiological saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TGRX-678 US Phase I for Subjects With Refractory or Advanced Chronic Myelogenous Leukemia
Status: RECRUITING
Conditions: Chronic Myelogenous Leukemia
Interventions: DRUG: TGRX-678
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prolonged Multimodal Analgesia for Post-Discharge Pain Control After Primary Total Hip Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis, Hip
Interventions: DRUG: Multi-modal with as needed opioids|DRUG: Multi-modal with one week of opioids offered|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Simplification to Atazanavir/Ritonavir + Lamivudine as Maintenance Therapy
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: Ritonavir boosted Atazanavir + Lamivudine|DRUG: Ritonavir boosted Atazanavir + 2 NRTIs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An A Study Assessing Subject Satisfaction With A-101 Topical Solution for Seborrheic Keratoses
Status: COMPLETED
Conditions: Seborrheic Keratosis
Interventions: DRUG: A-101 Topical Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DTx Algorithms for Personalized Parkinson's Disease Treatment and Medication Plan Optimization
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: Smartwatch Garmin Vivosmart [wearable sensor]|DEVICE: Soturi™ [digital mobile app]|OTHER: Clinical Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neo-adjuvant Treatment in Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cetuximab|DRUG: cisplatin|DRUG: docetaxel|RADIATION: Radiotherapy|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of a Seasonal Live Attenuated Influenza Vaccine in a Human Challenge Model of Infection With Wild-type (wt) Influenza A/California/2009 (H1N1)-Like Virus
Status: WITHDRAWN
Conditions: Influenza, Human
Interventions: BIOLOGICAL: Seasonal LAIV|BIOLOGICAL: Placebo|BIOLOGICAL: Wild-type A/California/2009-like Influenza Virus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Medication-overuse Headache (MOH): Withdrawal or Use of Preventative Medications Directly?
Status: COMPLETED
Conditions: Headache
Interventions: DRUG: Betablockers or other preventive drugs based on primary headache type
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gamified WellWe-intervention to Promote the Health and Wellbeing of Families With Small Children
Status: UNKNOWN
Conditions: Health Behavior|Healthy
Interventions: DEVICE: WellWe-Intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Liraglutide on Fatty Liver Content and Lipoprotein Metabolism
Status: TERMINATED
Conditions: Type 2 Diabetes
Interventions: DRUG: Liraglutide|DRUG: MRI/ MRS (Magnetic Resonance Imaging /Magnetic Resonance Spectroscopy)|BIOLOGICAL: Blood sample|OTHER: Kinetic substudy (10 patients)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Bendamustine and Rituximab Plus Venetoclax in Untreated Mantle Cell Lymphoma Over 60 Years of Age
Status: COMPLETED
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Venetoclax|DRUG: Bendamustine|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) Plus Chemotherapy vs Placebo Plus Chemotherapy as Neoadjuvant Therapy and Pembrolizumab vs Placebo as Adjuvant Therapy in Participants With Triple Negative Breast Cancer (TNBC) (MK-3475-522/KEYNOTE-522)
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple Negative Breast Neoplasms
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Doxorubicin|DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: Placebo|BIOLOGICAL: Granulocyte colony stimulating factor: Filgrastim or Pegfilgastrim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neurofeedback Training for Dyslexia
Status: UNKNOWN
Conditions: Dyslexia|Reading Problem
Interventions: DEVICE: ProComp5 Infiniti System w/BioGraph Infiniti Software|DEVICE: ProComp5 Infiniti System w/recorded videos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Corticosteroids During Covid-19 Viral Pneumonia Related to SARS-Cov-2 Infection
Status: TERMINATED
Conditions: Viral Pneumonia Human Coronavirus|COVID-19
Interventions: DRUG: Prednisone|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Proton Radiotherapy for the Treatment of Liver Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Hepatocellular Carcinoma|Stage I Hepatocellular Carcinoma AJCC v8|Stage II Hepatocellular Carcinoma AJCC v8|Stage III Hepatocellular Carcinoma AJCC v8
Interventions: RADIATION: Proton Stereotactic Body Radiation Therapy|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Antibiotic Administration Following Tooth Extraction
Status: NOT_YET_RECRUITING
Conditions: Tooth Extraction
Interventions: DRUG: 625 mg of amoxicillin with combined clavulanic acid tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas
Status: COMPLETED
Conditions: Chondrosarcomas|Alveolar Soft Part Sarcomas|Extra Skeletal Myxoid Chondrosarcomas
Interventions: DRUG: Perifosine|OTHER: Loperamide|OTHER: Allopurinol|OTHER: Antiemetics
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety, Tolerability, and Distribution of a Microdose of Radiolabeled BIIB067 (99mTc-MAG3-BIIB067) Co-administered With BIIB067 (Tofersen) to Healthy Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Tofersen|DRUG: 99mTc-MAG3-BIIB067
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PROSPECTIVE CONTROLLED AND RANDOMIZED STUDY OF THE GENITOURINARY FUNCTION AFTER RECTAL CANCER SURGERY IN RELATION TO THE DISSECTION OF THE INFERIOR MESENTERIC VESSELS
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: PROCEDURE: Inferior mesenteric Vein dissection|PROCEDURE: Inferior mesenteric Artery dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multimodal Preventive Trial for Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease; Prodromal
Interventions: OTHER: Regular health advice|BEHAVIORAL: Multidomain lifestyle|DIETARY_SUPPLEMENT: Medical food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity and Safety of Meningococcal Vaccine GSK 134612 Versus Mencevax™ ACWY in Healthy 18-25 Year Olds
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: Mencevax ACWY|BIOLOGICAL: GSK Biologicals' meningococcal serogroup A, C, W-135, Y tetanus toxoid conjugate investigational vaccine [GSK 134612]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Value of Radiotherapy in the Oligometastatic Non-squamous Non-small Cell Lung Cancer With Clinical Benefits From Erlotinib as Second-line Treatment
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer, Oligometastatic
Interventions: RADIATION: simultaneous radiotherapy|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: cisplatin|DRUG: docetaxel|DRUG: fluorouracil|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Malignant Pleural Effusion: Pleur-X vs. Chemical Pleurodesis in VATS
Status: UNKNOWN
Conditions: Malignant Pleural Effusion
Interventions: PROCEDURE: Pleur-X|PROCEDURE: Pleurodesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Safety and Efficacy of BTD-001 in Treatment of Patients With Idiopathic Hypersomnia (IH) or Narcolepsy Type 2
Status: COMPLETED
Conditions: Idiopathic Hypersomnia|Narcolepsy Without Cataplexy
Interventions: DRUG: BTD-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fiber-enriched Buckwheat Pasta and Glucose Variability in Patients With Type 1 Diabetes and Celiac Disease
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Celiac Disease
Interventions: OTHER: Acute test meal with fiber-enriched buckwheat pasta|OTHER: Acute test meal with corn pasta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of UGSB and GA to IV Narcotics and GA for Post-Op Pain in Children With Supracondylar Fractures.
Status: TERMINATED
Conditions: Supracondylar Fractures
Interventions: DRUG: Fentanyl|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of the Early Use of High Flow Nasal Cannula in Patients With Post-traumatic Lung Contusion, a Randomized Clinical Trial
Status: UNKNOWN
Conditions: Traumatic Lung Injury
Interventions: DEVICE: high flow nasal cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase IV, Multi-Center, Open-Label Trial of Sibutramine in Combination With a Hypocaloric Diet in Obese and Overweight Thai Subjects.
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: sibutramine hydochloride monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Reparixin in Pancreatic Islet Auto-transplantation
Status: COMPLETED
Conditions: Pancreatectomy for Chronic Pancreatitis
Interventions: DRUG: Reparixin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Meningococcal Quadrivalent CRM-197 Conjugate Vaccine Infant Study
Status: COMPLETED
Conditions: Meningococcal Disease|Infections, Meningococcal
Interventions: BIOLOGICAL: Meningococcal quadrivalent CRM-197 conjugate vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Influence of Pulse Electromagnetic Field Therapy on Myocardial Ischemia
Status: RECRUITING
Conditions: Coronary Artery Disease|Myocardial Infarction
Interventions: DEVICE: Pulsed electromagnetic field therapy (PEMF)|DEVICE: Inactive Pulsed electromagnetic field therapy (PEMF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Compare Efficacy and Safety of ABP 501 and Adalimumab (HUMIRA®) in Adults With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: BIOLOGICAL: Adalimumab|BIOLOGICAL: ABP 501
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Air vs. Cutaneous Control Mode for Preterm Infants ≤ 32 WG in Incubators: Impact on Body Growth and Morbidity
Status: RECRUITING
Conditions: Preterm Infant|Body Temperature
Interventions: PROCEDURE: air temperature control (ATC)|PROCEDURE: skin servocontrol (SSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Different Up-dosing Schedules With Osiris Phleum Pratense
Status: COMPLETED
Conditions: Rhino-conjunctivitis
Interventions: BIOLOGICAL: Osiris Phleum pratense|BIOLOGICAL: Osiris Phleum pratense|BIOLOGICAL: Osiris Phleum pratense
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Foot Orthotic for Early Stage Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Rheumatoid Arthritis of Foot (Disorder)
Interventions: DEVICE: Foot orthotics|DEVICE: Standard insole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE