pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Telehealth and Home-based Exercise and Rehabilitation Therapy for Acute Coronary Syndrome
Status: NOT_YET_RECRUITING
Conditions: Acute Coronary Syndrome|Coronary Artery Disease
Interventions: BEHAVIORAL: Tele-Rehabilitation Therapy|BEHAVIORAL: Health Education|BEHAVIORAL: Exercise Prescription|BEHAVIORAL: Home Exercise Equipment Use|BEHAVIORAL: Exercise Log|BEHAVIORAL: Follow-Up Calls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SSM vs HEP in Late-Life Depression
Status: TERMINATED
Conditions: Late-life Depression|Treatment-resistant Depression
Interventions: BEHAVIORAL: Sahaj Samadhi Meditation (SSM)|BEHAVIORAL: Health Enhancement Program (HEP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Dexamethasone for the Treatment of Acute Migraine Recurrence in the Pediatric Emergency Department
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Dexamethasone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Resilience-based Psychosocial Intervention Among Children Affected by HIV/AIDS
Status: COMPLETED
Conditions: Emotional Adjustment|Aids/Hiv Problem
Interventions: BEHAVIORAL: Child-Caregiver-Advocacy-Resilience [ChildCARE] intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bioavailability of Paracetamol, Amoxicillin and Talinolol Before, Immediately and One Year After Gastric Bypass Operation
Status: COMPLETED
Conditions: Morbid Obesity
Interventions: DRUG: paracetamol|DRUG: amoxicillin|DRUG: talinolol|PROCEDURE: gastroduodenoscopy with biopsy|PROCEDURE: gastrojejunoscopy with biopsy|PROCEDURE: proximal Roux-en-Y gastric bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study To Examine The Efficacy And Safety Of Pramlintide+Metreleptin In Obese Subjects
Status: TERMINATED
Conditions: Obesity
Interventions: DRUG: Pramlintide+Metreleptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoantigen Vaccine Therapy Against H3.3-K27M Diffuse Intrinsic Pontine Glioma
Status: RECRUITING
Conditions: Diffuse Intrinsic Pontine Glioma
Interventions: BIOLOGICAL: Histone H3.3-K27M Neoantigen Vaccine Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Bevacizumab + Sorafenib in Metastatic Breast Cancer
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Sorafenib|DRUG: Bevacizumab|OTHER: Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis Post-Approval Study
Status: NOT_YET_RECRUITING
Conditions: Abdominal Aortic Aneurysm|Pararenal Aortic Aneurysm|Thoracoabdominal Aortic Aneurysm
Interventions: DEVICE: GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis (TAMBE Device)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weight Maintenance Study for 2007 Shape UP RI Participants
Status: COMPLETED
Conditions: Weight Loss
Interventions: BEHAVIORAL: Increased Exercise for weight loss maintenance|BEHAVIORAL: Daily Self-weighing for weight loss maintenance|BEHAVIORAL: Education for weight loss maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Prospective Trial of the IAB in Adults Suffering From COPD/Emphysema
Status: ACTIVE_NOT_RECRUITING
Conditions: Emphysema|Pulmonary Disease, Chronic Obstructive
Interventions: DEVICE: IAB System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NANT 2021-01 Phase II STING (Sequential Temozolomide, Irinotecan, NK Cells and GD2 mAb) Trial
Status: NOT_YET_RECRUITING
Conditions: Neuroblastoma
Interventions: DRUG: Universal Donor (UD) TGFβi NK Cells|DRUG: Temozolomide|DRUG: Irinotecan|DRUG: Dinutuximab|DRUG: GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS)
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Arteriosclerosis|Coronary Disease|Heart Diseases|Myocardial Infarction|Myocardial Ischemia
Interventions: BEHAVIORAL: dietary supplements|DRUG: vitamin C|DRUG: vitamin E|DRUG: beta-carotene|DRUG: folic acid/Vitamin B6/Vitamin B12
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: |Primary Purpose: PREVENTION
Clinical trial: Comparison of Vildagliptin vs. Glimepiride on Glucose Variability in Metformin Uncontrolled Type 2 Diabetic Patients
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Vildagliptin|DRUG: Glimepiride|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Intravenous Anesthetics to Volatile Anesthetics on Postoperative Cognitive Dysfunction
Status: COMPLETED
Conditions: Intra-abdominal and Intrapelvic Surgery
Interventions: DRUG: Sevoflurane|DRUG: propofol|DRUG: remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Expressive Writing on Stress and Work-Related Outcomes Among Student Nurse Interns
Status: NOT_YET_RECRUITING
Conditions: Stress, Psychological
Interventions: OTHER: Expressive writing|OTHER: Neutral writing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: St. Jude Medical Angio-Seal VIP Vascular Closure Device
Status: COMPLETED
Conditions: Patients Requiring a Diagnostic and/or Interventional Diagnostic Procedure
Interventions: DEVICE: Angio-Seal VIP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemokine-Modulatory Regimen for Recurrent Resectable Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer|Colorectal Carcinoma|Colorectal Tumors|Neoplasms, Colorectal
Interventions: DRUG: Chemokin Modulatory Regimen (5 MU/m2)|DRUG: Chemokin Modulatory Regimen (10 MU/m2)|DRUG: Chemokin Modulatory Regimen (20 MU/m2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mild Hypothermia and Acute Kidney Injury in Liver Transplantation
Status: TERMINATED
Conditions: Cirrhosis|End Stage Liver Disease|Acute Kidney Injury|Liver Transplant; Complications|Chronic Kidney Diseases|Hepatitis c|Hepatitis B|NASH - Nonalcoholic Steatohepatitis|Alcoholic Cirrhosis|Hepatocellular Carcinoma
Interventions: DEVICE: Esophageal cooling/warming device|OTHER: Mild hypothermia|OTHER: Normothermia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Human Trial to Evaluate the Effects of Chungkookjang on Histamine-induced Wheal Size in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DIETARY_SUPPLEMENT: Chungkookjang|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Efficacy and Safety of Treatment With Bendamustine in Combination With Ofatumumab in Previously Untreated Patients With Indolent B-Cell Non-Hodgkin's Lymphoma (NHL)
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma (NHL)
Interventions: DRUG: Bendamustine hydrochloride|DRUG: Ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Degradable Microsphere in Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DEVICE: Nexsphere™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Approach to Assess Metabolic Flexibility in a Respiratory Chamber
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: High fat meal|OTHER: Low fat meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Denosumab on Periprosthetic Bone After Total Hip Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis, Hip|Ambulation Difficulty
Interventions: DRUG: denosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo
Status: COMPLETED
Conditions: HC-BPPV
Interventions: PROCEDURE: Gufoni maneuver|PROCEDURE: Head-shaking maneuver|PROCEDURE: sham maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy, Safety, Tolerability and Quality of Life of Inclisiran (KJX839) vs Placebo, on Top of Ongoing Individually Optimized Lipid-lowering Therapy, in Participants With Hypercholesterolemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypercholesterolemia
Interventions: DRUG: Inclisiran Sodium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Aripiprazole in the Treatment of Children and Adolescents With Autistic Disorder (AD)
Status: COMPLETED
Conditions: Autistic Disorder
Interventions: DRUG: Aripiprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of a Rilpivarine-based Antiretroviral Tratment Regimen in HIV- Infected Patients With Liver Metabolic Disease Who Maintain Udetectable HIV Viral Load
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections|Fatty Liver Disease
Interventions: DRUG: Dolutegravir (DTG) 50 mg/day + Rilpivirine (RPV) 25mg per day|DRUG: Tenofovir disoproxil fumarate (TDF) 245 mg per day or Tenofovir alafenamide (TAF) 25 mg per day + Emtricitabine (FTC) 200 mg per day + Rilpivirine 25 mg per day|DRUG: Continue with their previous treatment. Any previous HAART that does not contain Rilpivirine.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retrospective/Prospective Data Collection on the LDR ROIA Interbody Fusion Device With VerteBRIDGE Plating
Status: COMPLETED
Conditions: Degenerative Disc Disease
Interventions: DEVICE: ROIA Interbody Cage with VerteBRIDGE plating
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 1 Trial to Determine Dosimetry, Biodistribution and Safety of LMI 1195-101 in Healthy Subjects and Patients With Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: LMI 1195-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence Study of Generic GPO Saquinavir and Norvir® Versus Invirase® and Norvir®
Status: WITHDRAWN
Conditions: HIV Infections
Interventions: DRUG: generic GPO saquinavir and novir vs invirase and norvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Acupuncture for the Treatment of Postoperative Ileus After Gastrointestinal Surgery
Status: WITHDRAWN
Conditions: Postoperative Ileus|Gastrointestinal Cancer
Interventions: PROCEDURE: Electro-acupuncture|OTHER: Standard of Care Bowel rest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intra Hemodialytic Oral Protein and Exercise (IHOPE)
Status: COMPLETED
Conditions: Kidney Diseases
Interventions: DIETARY_SUPPLEMENT: Control|DIETARY_SUPPLEMENT: Protein|BEHAVIORAL: Protein + Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Imaging of 3D Innervation Zone Distribution in Spastic Muscles From High-density Surface EMG Recordings
Status: COMPLETED
Conditions: Spasticity
Interventions: DRUG: Botulinum neurotoxin (BTX)|OTHER: Physical Therapy|DEVICE: Standard BTX injection (ultrasound guided)|DEVICE: 3-dimensional innervation zone (3DIZ) guided injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Drug Levels of BMS-986256 in Participants With Active Cutaneous Lupus Erythematosus
Status: COMPLETED
Conditions: Lupus Erythematosus, Cutaneous
Interventions: DRUG: BMS-986256|OTHER: BMS-986256 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction With Metformin
Status: COMPLETED
Conditions: Healthy Male and Female Subjects
Interventions: DRUG: Dapagliflozin|DRUG: Metformin|DRUG: Dapagliflozin + Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Haploidentical Donor Hematopoietic Stem Cell Transplant in Treating Patients With Hematologic Malignancies
Status: TERMINATED
Conditions: Malignant Neoplasm
Interventions: RADIATION: Total-body irradiation|BIOLOGICAL: Donor lymphocytes infusion (DLI)|DRUG: Cyclophosphamide|PROCEDURE: Allogeneic hematopoietic stem cell transplantation (HSCT)|DRUG: Tacrolimus|DRUG: Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Antibiotic Protocol Guided by a Multimodal Approach in AECOPD With Pneumonia in Intensive Care
Status: NOT_YET_RECRUITING
Conditions: To Reduce Duration of Antibiotics Exposure in Patients With COPD Hospitalized in Intensive Care Unit With Pneumonia
Interventions: OTHER: experimental
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study to Evaluate the Effect of SLV320 on Renal Function in Patients With Worsening Heart Failure
Status: TERMINATED
Conditions: Acute Decompensated Heart Failure; Renal Dysfunction
Interventions: DRUG: SLV320|DRUG: SLV320|DRUG: SLV320|DRUG: SLV320|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of a Single-Dose Intravenous Administration of MEDI-528
Status: TERMINATED
Conditions: Asthma
Interventions: OTHER: PLACEBO|BIOLOGICAL: MEDI528 9 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of DaxibotulinumtoxinA for Blepharospasm and Hemifacial Spasm
Status: NOT_YET_RECRUITING
Conditions: Benign Essential Blepharospasm|Hemifacial Spasm
Interventions: DRUG: DaxibotulinumtoxinA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Cognitive-behavioral Therapy for Social Anxiety Disorder Using the Factorial Design
Status: COMPLETED
Conditions: Social Anxiety Disorder (Social Phobia)
Interventions: BEHAVIORAL: Exposure|BEHAVIORAL: Attention Training|BEHAVIORAL: Cognitive Restructuring|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Does High Intraoperative Inspired Oxygen Reduce Postoperative Arterial Oxygen Saturation?
Status: COMPLETED
Conditions: Atelectasis
Interventions: OTHER: FiO2 (fraction of inspired oxygen) 0.3 plus PEEP (positive end expiratory pressure) 3 -5 cm water|OTHER: FiO2 0.3 without PEEP|OTHER: FiO2 >0.9 with 3-5 cm water PEEP|OTHER: FiO2 >0.9 without PEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Selinexor (KPT-330) in Older Patients With Relapsed AML
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: Selinexor|DRUG: Hydroxyurea|DRUG: Ara-C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CR1447 in Endocrine Responsive-HER2neg and TN-ARpos Breast Cancer
Status: TERMINATED
Conditions: Metastatic Breast Adenocarcinoma|Breast Cancer
Interventions: DRUG: CR1447
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigation of the Absorption and Pharmacokinetics of Multiple Doses of Three Controlled Release Pregabalin Tablets as Compared to Multiple Doses of the Immediate Release Pregabalin Capsule
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pregabalin controlled release, 82.5 mg|DRUG: Pregabalin controlled release, 165 mg|DRUG: Pregabalin controlled release, 330 mg|DRUG: Pregabalin immediate release, 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Investigation of GLP-2 Mechanism of Action (GA-8)
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Inhibitor + GLP-2|OTHER: Placebo + GLP-2|OTHER: Placebo + GIP|OTHER: Placebo + Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Oat Bran on Bowel Function and Appetite
Status: WITHDRAWN
Conditions: Gastrointestinal Disorder, Functional
Interventions: OTHER: Oat bran (Oatwell 28)|OTHER: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Intake of Citron(Citrus Junos Siebold ex Tanaka) Peel Extract on Blood Cholesterol.
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DIETARY_SUPPLEMENT: Citron peel extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Multiple Ascending Doses of ZP4207 Administered to HV to Evaluate the Safety, Tolerability, PKs and PDs of ZP4207
Status: COMPLETED
Conditions: Hypoglycemia
Interventions: DRUG: ZP4207|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Effectiveness of Nuedexta in the Treatment of Pseudobulbar Affect (PBA)
Status: COMPLETED
Conditions: Pseudobulbar Affect (PBA)|Stroke|Dementia|Traumatic Brain Injury (TBI)
Interventions: DRUG: Nuedexta (DM 20 mg/Q 10 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intensified Post Remission Therapy Containing PEG-Asparaginase
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Daunorubicin, Vincristine, Prednisone, Methotrexate, PEG-Asparaginase, 6-Mercaptopurine, Cytoxan, Cytosine Arabinoside, VM-26 and 6-Thioguanine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Berberine and Dihydroberberine and Their Impact on Glycemia
Status: COMPLETED
Conditions: Glycemia
Interventions: DIETARY_SUPPLEMENT: Berberine|DIETARY_SUPPLEMENT: Dihydroberberine 200|DIETARY_SUPPLEMENT: Dihydroberberine 100|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: IMplementation of CAB+RPV LA for People With HIV in Non-Metropolitan Areas
Status: RECRUITING
Conditions: HIV
Interventions: BEHAVIORAL: Acceptability of Intervention Measure (AIM)|BEHAVIORAL: Intervention Appropriateness Measure (IAM)|BEHAVIORAL: Feasibility of Intervention Measure (FIM)|BEHAVIORAL: HIV Stigma Scale Questionnaire|BEHAVIORAL: HIV Treatment Satisfaction Questionnaire status version (HIVTSQs12)|BEHAVIORAL: HIV Treatment Satisfaction Questionnaire change version (HIVTSQc12)|BEHAVIORAL: Needs and Barriers Assessment|BEHAVIORAL: Pre-visit Outreach|BEHAVIORAL: Qualitative interview|BEHAVIORAL: Staff education
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Chemotherapy With or Without Veliparib in Treating Patients With Stage IV Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma|Stage IVA Oropharyngeal Carcinoma AJCC v7|Stage IVB Oropharyngeal Carcinoma AJCC v7
Interventions: DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Fluorouracil|DRUG: Hydroxyurea|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel|OTHER: Placebo Administration|RADIATION: Radiation Therapy|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-steroidal Anti-inflammatory Drugs Alone or With a Triptan and Reports of Transition From Episodic to Chronic Migraine
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: DRUG: Non-steroidal anti-inflammatory drug (NSAID)|DRUG: Triptan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Anti-thymocyte Globulin and Cyclosporine as First-Line Therapy in Treating Patients With Severe Aplastic Anemia
Status: COMPLETED
Conditions: Aplastic Anemia
Interventions: DRUG: cyclosporine|BIOLOGICAL: anti-thymocyte globulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebellar tDCS on Motor Learning of Healthy Individuals
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: tDCS|DEVICE: tDCS|DEVICE: tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety of DWP14012 Tablet A and Tablet B in Healthy Volunteers
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: DWP14012 tablet A|DRUG: DWP14012 tablet B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Insulin Glargine in Insulin Naïve Subjects With Type 2 Diabetes on Oral Hypoglycemic Agent(s)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: insulin glargine|DRUG: NPH human insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Phase Lll Study of Imatinib Dose Optimization vs Nilotinib in CML Patients With Suboptimal Response to Imatinib
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia
Interventions: DRUG: nilotinib|DRUG: imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Moxy Drug Coated Balloon vs. Standard Balloon Angioplasty for the Treatment of Femoropopliteal Arteries
Status: COMPLETED
Conditions: Femoral Artery Stenosis|Popliteal Artery Stenosis|Femoral Artery Occlusion|Popliteal Artery Occlusion
Interventions: PROCEDURE: Standard Uncoated Angioplasty Balloon|DEVICE: Moxy Drug Coated Balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II, Dose-finding Study of F-627 in Patients With Breast Cancer Receiving Myelotoxic Chemotherapy.
Status: COMPLETED
Conditions: Neutropenia
Interventions: BIOLOGICAL: F-627|BIOLOGICAL: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2b Study to Evaluate the Efficacy and Safety of CBL-514 Injection for Reducing Subcutaneous Fat.
Status: ACTIVE_NOT_RECRUITING
Conditions: Subcutaneous Fat
Interventions: DRUG: CBL-514 injection|DRUG: CBL-A1 Injection|DRUG: CBL-A2 Injection|DRUG: 0.9% Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Two Different Surgical Methods for Treatment for Abdominal Wall Diastasis
Status: COMPLETED
Conditions: Abdominal Hernias and Other Abdominal Wall Conditions|Post-operative Pain|Recurrence
Interventions: PROCEDURE: Quill suture application for repair or polypropylene mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Panobinostat Biological Correlates Study
Status: COMPLETED
Conditions: Nodal Lymphoma|Lymphoma With Cutaneous Involvement|Lymphoma in Leukemic Phase|Marrow Involvement With Lymphoma|Multiple Myeloma
Interventions: DRUG: panobinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Pegzilarginase in Patients With Arginase 1 Deficiency
Status: COMPLETED
Conditions: Arginase I Deficiency|Hyperargininemia
Interventions: DRUG: Pegzilarginase|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Halotherapy as Asthma Treatment in Children
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: Salt room with halogenerator|OTHER: Salt room without halogenerator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Intravitreal Aflibercept for Macular Edema Due to Central Retinal Vein Occlusion
Status: COMPLETED
Conditions: Retinal Vein Occlusion|Vascular Occlusive Disease
Interventions: DRUG: EYLEA 2 MG in 0.05 ML Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept of VLY-686 in Subjects With Treatment-Resistant Pruritus Associated With Atopic Dermatitis
Status: COMPLETED
Conditions: Treatment-resistant Pruritus Associated With Atopic Dermatitis
Interventions: DRUG: VLY-686|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Calcitriol vs. Placebo Among Critically-ill Patients With Sepsis
Status: COMPLETED
Conditions: Severe Sepsis or Septic Shock
Interventions: DRUG: Calcitriol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study to Examine Grape Seed Extract as an Anti-Oligomerization Agent in Alzheimer's Disease (AD)
Status: SUSPENDED
Conditions: Alzheimer's Disease
Interventions: DRUG: Meganatural-Az Grapeseed Extract|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Of Valsartan Used To Treat Hypertension For Up To 13 Months In Hypertensive Children Ages 6 - 16 Years Of Age
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Heat Loss Prevention in Very Preterm Infants in Delivery Rooms: A Multicenter, Randomized, Controlled Trial of Polyethylene Occlusive Total Body Skin Wrapping
Status: UNKNOWN
Conditions: Hypothermia|Preterm Infant
Interventions: DEVICE: Polyethylene wrap|DEVICE: Polyethylene wrap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Clinical Comparison of Somofilcon A 1 Day and Nelfilcon A Daily Disposable Contact Lenses
Status: COMPLETED
Conditions: Ametropia
Interventions: DEVICE: somofilcon A|DEVICE: nelfilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Nausea and Vomiting in Postoperative Paediatric Patients With Patient-Controlled Analgesia (PCA): Morphine vs Oxycodone
Status: RECRUITING
Conditions: Patient-Controlled Analgesia
Interventions: DRUG: Morphine|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adavosertib Before Surgery in Treating Patients With Advanced High Grade Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Fallopian Tube Carcinoma|Advanced Ovarian Carcinoma|Advanced Primary Peritoneal Carcinoma|Carcinomatosis|Fallopian Tube High Grade Serous Adenocarcinoma|Ovarian High Grade Serous Adenocarcinoma|Primary Peritoneal High Grade Serous Adenocarcinoma|Stage III Fallopian Tube Cancer AJCC v7|Stage III Ovarian Cancer AJCC v6 and v7|Stage III Primary Peritoneal Cancer AJCC v7|Stage IIIA Fallopian Tube Cancer AJCC v7|Stage IIIA Ovarian Cancer AJCC v6 and v7|Stage IIIA Primary Peritoneal Cancer AJCC v7|Stage IIIB Fallopian Tube Cancer AJCC v7|Stage IIIB Ovarian Cancer AJCC v6 and v7|Stage IIIB Primary Peritoneal Cancer AJCC v7|Stage IIIC Fallopian Tube Cancer AJCC v7|Stage IIIC Ovarian Cancer AJCC v6 and v7|Stage IIIC Primary Peritoneal Cancer AJCC v7|Stage IV Fallopian Tube Cancer AJCC v6 and v7|Stage IV Ovarian Cancer AJCC v6 and v7|Stage IV Primary Peritoneal Cancer AJCC v7
Interventions: DRUG: Adavosertib|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety, Tolerability, and PK of MRX-8 Administered Intravenously to HVs in SAD and MAD Cohorts
Status: COMPLETED
Conditions: Safety
Interventions: DRUG: MRX-8|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Ablation for Malignant Biliary Obstruction
Status: COMPLETED
Conditions: Biliary Tract Neoplasms
Interventions: PROCEDURE: Endoscopic radiofrequency ablation|PROCEDURE: Endoscopic retrograde cholangiopancreatography (ERCP)|DEVICE: HabibTM EndoHPB catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Prospective Randomized Controlled Study of Eltrombopag on Hematopoietic Reconstruction After Allogeneic HSCT
Status: UNKNOWN
Conditions: Allogeneic Hematopoietic Stem Cell Transplantation|Eltrombopag
Interventions: DRUG: Eltrombopag
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Testing Maintenance Therapy for Small Cell Lung Cancer in Patients With SLFN11 Positive Biomarker
Status: ACTIVE_NOT_RECRUITING
Conditions: Extensive Stage Lung Small Cell Carcinoma
Interventions: DRUG: Atezolizumab|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Talazoparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture as Migraine Prophylaxis in Reducing Frequency, Duration and Intensity of Migraine With Minimum Acupoint, Seen up to Eight Weeks From Baseline
Status: COMPLETED
Conditions: Migraine|Headache|Migraine Disorders
Interventions: OTHER: acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF)
Status: RECRUITING
Conditions: Cystic Fibrosis
Interventions: DRUG: VX-522 mRNA therapy|DRUG: IVA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Yoga and Meditation on The Birth Process
Status: COMPLETED
Conditions: Birth, First|Labor Pain|State Anxiety|Self Efficacy
Interventions: BEHAVIORAL: yoga and meditation|BEHAVIORAL: Birth preparation training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Bitopertin (RO4917838) in Adults With Non-Transfusion-Dependent (NTD) Beta-Thalassemia
Status: COMPLETED
Conditions: Beta-Thalassemia
Interventions: DRUG: Bitopertin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Understanding How Alzheimer's Disease Impacts the Therapeutic Response to Transcranial Direct Current Stimulation
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: OTHER: tDCS and Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Use of Extracorporeal Cytokine Adsorption During Orthotopic Heart Transplantation
Status: COMPLETED
Conditions: Cardiac Transplantation|Cardiopulmonary Bypass
Interventions: DEVICE: CytoSorb®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Gastric Volumes by US in Term Parturients Undergoing CS With and Without Metoclopramide
Status: COMPLETED
Conditions: Pregnancy|Cesarean Section|Aspiration
Interventions: DRUG: Study drug metoclopramide|DRUG: Study drug placebo administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nasospore Stent For Use in Enodscopic Sinus Surgery
Status: WITHDRAWN
Conditions: Chronic Sinusitis
Interventions: DRUG: Merogel Nasal Stent and Nasopore Stent|DRUG: Nasopore Stent and either Gentamycin or Bacitracin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Changing the Activation Frequency of the Arch Wires on the Rate of Leveling and Alignment in Moderate Crowding Cases
Status: UNKNOWN
Conditions: Leveling and Alignment of Teeth
Interventions: OTHER: 6 weeks changing of archwire|OTHER: 4 weeks changing of archwire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tandem Melphalan and Autolog. SCT in MM Patients 60 to 70 Years of Age With and Without Induction Chemotherapy
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Anthracycline/dexamethasone-based induction chemotherapy|DRUG: Dexamethasone for control of symptoms|DRUG: Tumor-reduction chemotherapy and stem cell mobilization|PROCEDURE: Stem cell apheresis|DRUG: Tandem high-dose chemotherapy (melphalan)|PROCEDURE: Autologous peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study Adding Pracinostat to a Hypomethylating Agent (HMA) in Patients With MDS Who Failed to Respond to Single Agent HMA
Status: COMPLETED
Conditions: Myelodysplastic Syndrome|MDS
Interventions: DRUG: pracinostat|DRUG: Azacitidine|DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phased-Implementation Feasibility and Proof-of-Concept Study to Assess Incorporating the NIDA CTN Common Data Elements (CDEs) Into the Electronic Health Record (EHR) in Large Primary Care Settings ("CDE-EHR-PC" Study), Phase 2
Status: COMPLETED
Conditions: Substance Abuse
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of KOVIR in the Combination Regimen With Background Treatment in COVID-19 Patients (KOVIR)
Status: COMPLETED
Conditions: COVID-19
Interventions: DIETARY_SUPPLEMENT: KOVIR oral capsule|DIETARY_SUPPLEMENT: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Investigate Real Life Effectiveness of Symbicort Maintenance and Reliever Therapy in Asthma Patients Across Asia
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Symbicort (Budesonide/Formoterol)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Effectiveness of EGb 761® vs Placebo Used for Cognitive Impairment in Patients With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: EGb 761® (Tanakan®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of BKM120 & Rituximab in Patients With Relapsed or Refractory Indolent B-Cell Lymphoma
Status: COMPLETED
Conditions: Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Splenic Marginal Zone Lymphoma|Waldenström Macroglobulinemia
Interventions: DRUG: PI3K inhibitor BKM120|BIOLOGICAL: rituximab|OTHER: Pharmacodynamics|OTHER: Correlative studies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concurrent EGFR-TKIs and Thoracic Radiation Therapy in Active EGFR Mutation for 1st Line Treatment of Stage IV NSCLC
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: EGFR-TKIs|RADIATION: thoracic radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Ticagrelor Re-load on Pharmacodynamic Profiles
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Ticagrelor 180mg|DRUG: Ticagrelor 90mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Oral Hair Supplement to Improve Hair Strength and Support Growth in Women and Men
Status: RECRUITING
Conditions: Hair Thinning
Interventions: DIETARY_SUPPLEMENT: Nutrafol Women's Hair Growth Supplemnt|DIETARY_SUPPLEMENT: Nutrafol Women's Balance Hair Growth Supplement|DIETARY_SUPPLEMENT: Nutrafol Women's Vegan Hair Growth Supplement|DIETARY_SUPPLEMENT: Nutrafol Women's Postpartum Hair Growth Supplement|DIETARY_SUPPLEMENT: Nutrafol Men's Hair Growth Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Ketamine on Fatigue Following Cancer Therapy
Status: TERMINATED
Conditions: Cancer|Fatigue|Ketamine
Interventions: DRUG: Ketamine|DRUG: Placebo (saline)|DRUG: Ketamine|DRUG: Midazolam|DRUG: Midazolam(placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1-2 Trial of Cetuximab in Combination With Oxaliplatin, Capecitabine, and Radiation Therapy Followed by Surgery for Locally-advanced Rectal Cancer
Status: TERMINATED
Conditions: Rectal Cancer|Colo-rectal Cancer
Interventions: DRUG: Cetuximab|DRUG: Oxaliplatin|DRUG: Capecitabine|RADIATION: Radiotherapy|DRUG: Diphenhydramine hydrochloride (HCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Relative Abuse Potential of Hydrocodone Bitartrate and Acetaminophen
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Placebo|DRUG: Hydrocodon bitartrate-acetaminophen arm 1|DRUG: Hydrocodon bitartrate-acetaminophen arm 2|DRUG: Reference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-blinded, Placebo-controlled, Dose-escalation Phase 1 Clinical Trial to Evaluate the Safety and Immunogenicity of Recombinant HIV Envelope Protein BG505 SOSIP.664 gp140 Vaccine, Adjuvanted, in Healthy, HIV-1 Uninfected Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: BG505 SOSIP.664 gp140, adjuvanted|BIOLOGICAL: BG505 SOSIP.664 gp140, adjuvanted|BIOLOGICAL: BG505 SOSIP.664 gp140, adjuvanted|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Empagliflozin for No-reflow Phenomenon in PCI for STEMI
Status: NOT_YET_RECRUITING
Conditions: STEMI|No-Reflow Phenomenon
Interventions: DRUG: Empagliflozin 25 milgrams (Mg)|DRUG: Empagliflozin 10 Mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 2 Study to Assess Efficacy and Safety of LB54640 in Patients With Genetic Obesity
Status: NOT_YET_RECRUITING
Conditions: POMC Deficiency Obesity|PCSK1 Deficiency Obesity|LEPR Deficiency Obesity
Interventions: DRUG: LB54640
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Trial of Antibiotic Eluting Graft for Promoting New Bone Growth in/Near Infected Bone Cavities
Status: RECRUITING
Conditions: Periprosthetic Joint Infections
Interventions: DEVICE: EP Granules with Tobramycin|DEVICE: empty voids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)
Status: COMPLETED
Conditions: Reperfusion Injury
Interventions: DRUG: Antithrombin-III|DRUG: Infliximab|DRUG: Apotransferrin|DRUG: Human recombinant erythropoietin|DRUG: C1-Inhibitor|DRUG: Glutathione|DRUG: Alfa-tocopherol|DRUG: Melatonin|DRUG: Epoprostenol|DRUG: Sodium chloride solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study to Assess the Efficacy and Safety of Batoclimab as Induction and Maintenance Therapy in Adult Participants With Generalized Myasthenia Gravis
Status: ACTIVE_NOT_RECRUITING
Conditions: Generalized Myasthenia Gravis
Interventions: DRUG: Batoclimab 680 mg SC weekly|DRUG: Batoclimab 340 mg SC weekly|DRUG: Matching Placebo SC|DRUG: Batoclimab 340 mg SC bi-weekly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Nitric Oxide in Optic Nerve Head Blood Flow Regulation During Isometric Exercise in Healthy Humans
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: NG-monomethyl-L-arginine (L-NMMA)|DRUG: Phenylephrine|DRUG: Physiological saline solution (as placebo)|DEVICE: Laser Doppler Flowmetry|DEVICE: Goldmann applanation tonometer|OTHER: squatting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Efficacy and Safety of Bedaquiline (TMC207) in Participants With Multibacillary Leprosy
Status: COMPLETED
Conditions: Leprosy, Multibacillary
Interventions: DRUG: Bedaquiline 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eval 3-Drug Therapy Diethylcarbamize, Albendazole and Ivermectin That Could Accelerate LF Elimination Outside of Africa
Status: COMPLETED
Conditions: Lymphatic Filariasis
Interventions: DRUG: Diethylcarbamazine|DRUG: Albendazole|DRUG: Ivermectin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT