pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Cetuximab in Combination With mFOLFOX-6 (Oxaliplatin, Leucovorin, 5-FU) to Treat Colorectal Liver Metastatic Cancer Patients
Status: UNKNOWN
Conditions: Colorectal Cancer|Liver Metastases
Interventions: DRUG: Cetuximab; mFOLFOX6
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FUVID Study: Functional Characterization of Children With Chronic Venous Thromboembolic Disease
Status: RECRUITING
Conditions: Deep Venous Thrombosis|Pulmonary Embolism
Interventions: DIAGNOSTIC_TEST: Blood draw (Visit 1)|DIAGNOSTIC_TEST: Blood draw (Visits 2 and 3)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of the Timing of Colloid and Crystalloid Infusions on Postspinal Hypotension After Spinal Anesthesia for Caesarian Section
Status: COMPLETED
Conditions: Complications; Anesthesia, Spinal and Epidural, in Pregnancy
Interventions: OTHER: Colloid Preload|OTHER: colloid co-load|OTHER: Crystalloid preload|OTHER: Crystalloid Co-load
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Examine the Use of Zemplar to Increase Serum Calcium Levels in ICU Subjects
Status: COMPLETED
Conditions: Hypocalcemia
Interventions: DRUG: paricalcitol injection (Zemplar)|BEHAVIORAL: Effects on calcium regulation|BEHAVIORAL: Administration of elemental Ca during hypocalcemic ICU pts.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of SR Bupropion for Adolescent Smoking Cessation
Status: UNKNOWN
Conditions: Smoking|Smoking Cessation
Interventions: DRUG: Bupropion|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: dexamethasone|DRUG: melphalan|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Trial of Therapeutic Hepatitis B Vaccine (Mimogen-based) for Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: BIOLOGICAL: εPA-44|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Apollo Micro Catheter in Pediatric Patients
Status: COMPLETED
Conditions: Brain Arteriovenous Malformation|Brain Vascular Malformations|Vein of Galen Malformation
Interventions: DEVICE: Apollo Micro Catheter device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Pharmacological Intervention Project (Fluoxetine)
Status: COMPLETED
Conditions: Alcoholism|Depression
Interventions: DRUG: fluoxetine (Prozac)|DRUG: Placebo plus Treatment As Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Home-based Community Health Worker Program in Rural Eastern Cape, South Africa
Status: COMPLETED
Conditions: HIV Infections|HIV/AIDS|Depression|Depressive Symptoms|Alcohol Use Disorder|Alcohol Drinking|Stunting|Alcohol; Harmful Use|Child Development|Child Malnutrition|Child Nutrition Disorders|Birth Weight Less Than 10Th Percentile
Interventions: BEHAVIORAL: Comprehensive CHW Program
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Whole Body MRI to Identify Atypical Neurofibromas in Patients With NF1
Status: ACTIVE_NOT_RECRUITING
Conditions: Neurofibromatosis 1|Neurofibroma|Atypical Neurofibroma|Atypical Neurofibromatosis|Plexiform Neurofibroma|Von Recklinghausen Disease
Interventions: DIAGNOSTIC_TEST: Whole Body MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prospective Randomised Study of Doxorubicin in the Treatment of Hepatocellular Carcinoma by Drug-Eluting Bead Embolisation
Status: COMPLETED
Conditions: Primary Liver Cancer
Interventions: DEVICE: Transarterialchemoembolisation (TACE)|DEVICE: DC Bead with Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Breast Cancer: Axillary Conservation After Neoadjuvant Chemotherapy in Micro Metastatic Sentinel Lymph Nodes.
Status: RECRUITING
Conditions: Breast Cancer
Interventions: PROCEDURE: Omission of Axillary dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Intra Versus Extrahepatic Division of Right Hepatic Vein During Rightsided Hemihepatectomy
Status: UNKNOWN
Conditions: Reduction of Peroperative Blood Loss During Liver Resection
Interventions: PROCEDURE: Intrahepatic division of the right hepatic vein.|PROCEDURE: Extrahepatic vein division
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Valsartan Plus Hydrochlorothiazide and Amlodipine in Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Valsartan plus Hydrochlorothiazide (80mg/12.5mg)|DRUG: Amlodipine (5mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine and Blood Coagulation
Status: COMPLETED
Conditions: Blood Coagulation Disorder
Interventions: DRUG: 0 ul of dexmedetomidine|DRUG: 0.25 ul of dexmedetomidine|DRUG: 0.5 ul of dexmedetomidine|DRUG: 0.75 ul of dexmedetomidine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Surgeon Emotional Support on Treatment Choice for Low-risk Thyroid Cancer
Status: COMPLETED
Conditions: Thyroid Cancer|Thyroid Nodule|Benign Thyroid Nodule
Interventions: OTHER: Emotionally Supportive Video|OTHER: Standard Video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of a Habit-based Work-up to Support Medication Adherence
Status: RECRUITING
Conditions: Medication Adherence|Habits
Interventions: BEHAVIORAL: Habit workup|BEHAVIORAL: Standard Medication Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Extension Study in Participants With Moderate to Severe Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Baricitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Web-based Tailored Information and Support for Patients With a Neuroendocrine Tumor
Status: COMPLETED
Conditions: Neuroendocrine Tumor
Interventions: OTHER: Web-based tailored information and support system|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Viral Specific T-Lymphocytes to Treat Adenovirus or CMV
Status: ACTIVE_NOT_RECRUITING
Conditions: Adenovirus|Cytomegalovirus Infections
Interventions: BIOLOGICAL: Adenovirus Specific T- Lymphocytes|BIOLOGICAL: Cytomegalovirus Specific T-Lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 12-week Treatment With Inhaled Tiotropium (18 mcg Once Daily) on Lung Function and Static Lung Volumes in Stable, Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) Patients. Correlation to Dyspnoea Scales
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium inhalation capsules|DRUG: Placebo inhalation capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Performance of Aspheric Hydrogel Lenses After a Refit With Sphere Silicone Hydrogel Lenses for 4 Weeks
Status: COMPLETED
Conditions: Ametropia
Interventions: DEVICE: methafilcon A contact lenses|DEVICE: fanfilcon A contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Causes and Prevention of Thromboembolic Disease in Nephrotic Syndrome
Status: UNKNOWN
Conditions: Nephrotic Syndrome|Thromboembolic Disease
Interventions: DRUG: Dalteparin|DRUG: Apixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Inflammatory Response to Stress and Angiogenesis in Liver Resection
Status: COMPLETED
Conditions: Liver Cancer|Colorectal Cancer|Metastatic Cancer|Liver Metastases
Interventions: PROCEDURE: Liver resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: QoL and Stress in Parents of Children With Developmental Disabilities and Chronic Disease
Status: UNKNOWN
Conditions: Developmental Disability|Chronic Disease|Down Syndrome|Autism Spectrum Disorder|Pervasive Developmental Disorder|Cerebral Palsy|Diabetes Mellitus, Type 1|Epilepsy|Asthma|Stress
Interventions: DIAGNOSTIC_TEST: salivary cortisol|DEVICE: Holter Medilog AR12 Plus|DEVICE: Polar V800|DEVICE: AGE reader
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Short-Term Clinical Comparison of Two Silicone Hydrogel Daily Disposable Contact Lenses
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: Test 8.5BC|DEVICE: Test 9.0BC|DEVICE: Control 8.5BC|DEVICE: Control 9.0BC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Osimertinib and Navitoclax in Treating Patients With EGFR-Positive Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Advanced Lung Non-Squamous Non-Small Cell Carcinoma|Metastatic Lung Non-Squamous Non-Small Cell Carcinoma|Stage III Lung Non-Small Cell Cancer AJCC v7|Stage IIIA Lung Non-Small Cell Cancer AJCC v7|Stage IIIB Lung Non-Small Cell Cancer AJCC v7|Stage IV Lung Non-Small Cell Cancer AJCC v7
Interventions: DRUG: Navitoclax|DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Suction Intervention to Reduce Aspiration and Ventilator Events: NO-ASPIRATE
Status: COMPLETED
Conditions: Respiratory Failure
Interventions: OTHER: Enhanced oropharyngeal suction|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose-response Study of OPC-12759 Ophthalmic Suspension
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: 0.5% OPC-12759|DRUG: 1% OPC-12759|DRUG: 2% OPC-12759|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brief Bactericidal Activity of Anti-Tuberculosis Drugs
Status: COMPLETED
Conditions: Tuberculosis|Drug-resistant Tuberculosis|Isoniazid Resistant Tuberculosis (Disorder)
Interventions: DRUG: High dose isoniazid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predicting the Efficacy of Resistance Exercise Training for Improving Endurance Performance
Status: COMPLETED
Conditions: Elite Cyclists
Interventions: BEHAVIORAL: Resistance training|BEHAVIORAL: Endurance training (habitual)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Shock Wave Therapy on Diabetes Related Frozen Shoulder
Status: COMPLETED
Conditions: Frozen Shoulder|Diabetes Mellitus
Interventions: DEVICE: Extracorporeal Shock Wave Therapy|OTHER: Placebo ESWT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Effect of Buspirone on Esophageal Function and Esophageal Symptoms in Patients With Systematic Sclerosis (SSc)
Status: COMPLETED
Conditions: Systemic Sclerosis
Interventions: DRUG: buspirone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Design, Prototyping, and Testing of a Robotic Prosthetic Leg
Status: COMPLETED
Conditions: Amputation; Traumatic, Leg, Lower
Interventions: OTHER: Phase 2 Prescribed Prosthesis|OTHER: Phase 2 Robotic Prosthetic Leg|OTHER: Phase 3 No Prosthesis|OTHER: Phase 3 Robotic Prosthetic Leg|OTHER: Phase 3 Prescribed Prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Assess Analgesic Efficacy and Safety of ASP3662 in Subjects With Painful Diabetic Peripheral Neuropathy
Status: TERMINATED
Conditions: Painful Diabetic Peripheral Neuropathy (PDPN)
Interventions: DRUG: ASP3662|DRUG: pregabalin|DRUG: ASP3662 placebo|DRUG: pregabalin placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Feasibility of 1-step Injectable Artesunate vs. Conventional 2-step Injectable Artesunate
Status: COMPLETED
Conditions: Severe Malaria
Interventions: DRUG: Argesun 60mg (1 step parenteral artesunate)|DRUG: Artesun 60mg (2-step parenteral artesunate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP)
Status: COMPLETED
Conditions: Thrombocytopenia|Idiopathic Thrombocytopenic Purpura
Interventions: BIOLOGICAL: romiplostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Study Of SB-485232 (Interleukin 18) And Doxil For Advanced Stage Epithelial Ovarian Cancer
Status: COMPLETED
Conditions: Neoplasms, Ovarian
Interventions: DRUG: SB-485232 (interleukin 18), pegylated liposomal doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Results of Arthroscopic-Assisted Lower Trapezius Tendon Transfer for Massive, Irreparable Rotator Cuff Tears
Status: RECRUITING
Conditions: Massive Irreparable Rotator Cuff Tears
Interventions: PROCEDURE: Arthroscopic-assisted lower trapezius tendon transfer surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Role of the Noradrenergic System in Pain Perception in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: duloxetine|DRUG: placebo of duloxetine|DRUG: injection of apomorphine|DRUG: injection of placebo of apomorphine|DRUG: L-Dopa|DRUG: injection of placebo of L-Dopa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intensive Versus Conventional Hyperglycemic Control in Hospitalized Non-critically Ill Patients
Status: RECRUITING
Conditions: Diabetes Mellitus|Non-critically Ill Patients
Interventions: DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study Comparing Low- and High-Dose Alemtuzumab and High-Dose Rebif® in Patients With Early, Active Relapsing-Remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: BIOLOGICAL: Interferon beta-1a|BIOLOGICAL: Alemtuzumab 12 mg|BIOLOGICAL: Alemtuzumab 24 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Efficacy of Two Adjuvants During Spinal Anaesthesia.
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Saline Solution|DRUG: Magnesium Sulfate|DRUG: Midazolam 5 MG/ML Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Irritable Bowel Syndrome With Diarrhea (IBS-D) Rifaximin Re-Treatment Study
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Diarrhea
Interventions: DRUG: open-label rifaximin|DRUG: double-blind placebo|DRUG: double-blind rifaximin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Piloting a Smartphone App to Improve Treatment Adherence Among South African Adolescents Living With HIV
Status: COMPLETED
Conditions: HIV Infections|Adolescent Behavior
Interventions: BEHAVIORAL: Social Support|BEHAVIORAL: Informational Resources|BEHAVIORAL: Self-Monitoring and habit formation|BEHAVIORAL: Goal setting and action planning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic & Pharmacodynamic Study of ABT-751 With Carboplatin in Patients With Advanced Lung Cancer
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer|Lung Cancer
Interventions: DRUG: ABT-751 and Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Prevalence of Local Immunoglobulin E (IgE) Elevation and Its Effect on Intranasal Capsaicin Therapy in the Non-allergic Rhinitis Population
Status: RECRUITING
Conditions: Non-allergic Rhinitis
Interventions: DRUG: Intranasal capsaicin|DRUG: topical lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Long-term Effect of D4 Lymphadenectomy for Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer|Surgery|Effects of Chemotherapy
Interventions: PROCEDURE: Radical Gastrectomy Plus D2 Lymphadenectomy|PROCEDURE: Radical Gastrectomy Plus D4 Lymphadenectomy|DRUG: S-1+Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Adjuvant Chemotherapy of Asymptomatic Resectable Primary Lesion With Unresectable Liver-limited Metastases
Status: COMPLETED
Conditions: Colorectal Neoplasms|Neoplasm Metastasis|Liver Neoplasms|Chemotherapy; Maternal, Affecting Fetus
Interventions: DRUG: chemotherapy ± targeted therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Re-Dosing With Otelixizumab in Adults With Newly-Diagnosed Type 1 Diabetes Mellitus
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 1
Interventions: BIOLOGICAL: otelixizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase Ib Study of BKM120 With Cisplatin and XRT in High Risk Locally Advanced Squamous Cell Cancer of Head and Neck
Status: COMPLETED
Conditions: Carcinoma, Squamous Cell of Head and Neck|HPV Positive Oropharyngeal Squamous Cell Carcinoma|Hypopharyngeal Cancer|Early Invasive Cervical Squamous Cell Carcinoma|Carcinoma of Larynx|Cancer of Nasopharynx
Interventions: DRUG: BKM120|DRUG: Cisplatin|RADIATION: Intensity-modulated radiotherapy (IMRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Progressive Relaxation Exercise on Caregiver Burden, Fatigue and Quality of Life in Caregivers of Patients With Advanced Cancer: Randomized Controlled Clinical Study
Status: UNKNOWN
Conditions: Caregiver Burnout|Cancer
Interventions: BEHAVIORAL: Progressive muscle relaxation|OTHER: Attention matched control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Namilumab vs Adalimumab in Participants With Moderate to Severe Early Rheumatoid Arthritis Inadequately Responding to Methotrexate
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Namilumab|DRUG: Adalimumab|DRUG: Methotrexate|DRUG: Folic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Androgen Deprivation Therapy in Advanced Salivary Gland Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Salivary Gland Cancer
Interventions: DRUG: bicalutamide + triptorelin|DRUG: Cisplatin + Doxorubicin|DRUG: Carboplatin + Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 10 vs 14 Days Triple Therapy : H.Pylori Infection Eradication
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Rabeprazole Sodium 20mg|DRUG: Clarithromycin 500mg|DRUG: Amoxicillin 500 Mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DA-EPOCH-R Induction Followed by Nivolumab Consolidation in Newly Diagnosed MYC, BCL2 and/or BCL6 Rearranged HGBL
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Hodgkin Lymphoma|Lymphoma, B-Cell|High-grade B-cell Lymphoma|MYC Translocation|BCL-2 Translocation
Interventions: DRUG: DA-EPOCH-R followed by Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Different Concentrations of an Ingenol Derivative Field Therapy in the Treatment of Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Ingenol once daily for two consecutive days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Local Delivery of Paclitaxel Via the TAPAS Catheter to Prevent Restenosis From Percutaneous Femoropopliteal Intervention
Status: UNKNOWN
Conditions: Restenosis|Peripheral Arterial Disease
Interventions: DRUG: Paclitaxel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Efficacy and Safety of YH12852 in Patients With Functional Dyspepsia
Status: TERMINATED
Conditions: Functional Dyspepsia
Interventions: DRUG: YH12852 0.1 mg|DRUG: YH12852 0.25 mg|DRUG: YH12852 0.5 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nipple Secretion Samples in Detecting Breast Cancer in Patients and Healthy Participants Undergoing Breast Cancer Screening, Breast Diagnostic Studies, or Treatment for Benign Breast Disease
Status: TERMINATED
Conditions: Breast Cancer
Interventions: GENETIC: protein analysis|GENETIC: protein expression analysis|GENETIC: proteomic profiling|OTHER: diagnostic laboratory biomarker analysis|OTHER: immunohistochemistry staining method|OTHER: liquid chromatography|OTHER: mass spectrometry|PROCEDURE: fine-needle aspiration|PROCEDURE: needle biopsy|PROCEDURE: radiomammography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 1b/2 Study of the Combination of IMCgp100 With Durvalumab and/or Tremelimumab in Advanced Cutaneous Melanoma
Status: WITHDRAWN
Conditions: Malignant Melanoma
Interventions: DRUG: Tebentafusp (IMCgp100)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab in Combination With Outpatient Therapy for CD20+ Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma (CD20+)
Interventions: DRUG: gemcitabine|DRUG: vinorelbine|DRUG: ifosfamide|DRUG: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of TQH2722 Injection in the Treatment of Chronic Sinusitis With or Without Nasal Polyps.
Status: RECRUITING
Conditions: Sinusitis
Interventions: DRUG: 300mg of TQH2722 injection|DRUG: 600mg of TQH2722 injection|DRUG: TQH2722 injection matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of a Polyethyleneimine-coated Membrane (oXiris™) for Hemofiltration Versus Polymyxin B- Immobilized Fibre Column (Toraymyxin™) for Hemoperfusion on Endotoxin Activity and Inflammatory Conditions in Septic Shock- A Randomized Controlled Pilot Study (ENDoX-study)
Status: COMPLETED
Conditions: Patients in Septic Shock
Interventions: DEVICE: oXiris™ filter|DEVICE: Toraymyxin Filter|DEVICE: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stimulating Neural Activity to Improve Blood Flow and Reduce Amyloid: Path to Clinical Trials
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DEVICE: Flicker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Taste Test Between Desloratadine and Cetirizine Syrup in Children (Study P03829)(COMPLETED)
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Desloratadine (Clarinex)|DRUG: Cetirizine (Zyrtec)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Clinical Trial to Evaluate Safety and Efficacy of Endovascualr Denervation in Treatment of Cancer Pain
Status: UNKNOWN
Conditions: Liver Cancer|Pancreas Cancer|Stomach Cancer|Bile Duct Cancer
Interventions: DEVICE: Endovascular Denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Repeated Dose Study of the Metabolism and Action Evaluation of OROS Hydromorphone HCI (Slow Release) Tablets in Patients With Chronic Pain
Status: COMPLETED
Conditions: Pain|Analgesics, Opioid
Interventions: DRUG: OROS Hydromorphone HCI (slow release)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: What is the Incidence of Pressure Ulcer Category II-IV (Including Deep-tissue Injury and Unstageable) on a Static Air Foam Hybrid Mattress?
Status: COMPLETED
Conditions: Pressure Ulcer|Pressure Injury|Pressure Sore|Bed Sore
Interventions: DEVICE: Ultracore Repose® mattress
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Reactive Stepping Training in Individuals With Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: BEHAVIORAL: Perturbation-based training|BEHAVIORAL: Conventional walking training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GHB Withdrawal Symptoms and Effectiveness of Treatment With Lorazepam Versus Pentobarbital - 1
Status: WITHDRAWN
Conditions: Substance-Related Disorders
Interventions: DRUG: Lorazepam|DRUG: Pentobarbital
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Two Approved Drugs in the Treatment of Post-Bunionectomy Surgery Pain (0966-234)(COMPLETED)
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: MK0966, rofecoxib|DRUG: Comparator: diclofenac sodium, placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A PK Study of 3 Dosages of Tolvaptan in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
Status: COMPLETED
Conditions: Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
Interventions: DRUG: tolvaptan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Registry to Gather Long-time Results After Surgical Aortic Valve Replacement With a "Rapid Deployment Aortic Valve Prothesis (Edwards Intuity) Combined With Bypss Surgery (CABG)
Status: COMPLETED
Conditions: Aortic Valve Stenosis|Coronary Artery Disease
Interventions: PROCEDURE: AVR and CABG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Bevacizumab Versus Pulvis Talci in Malignant Pleural Effusion
Status: UNKNOWN
Conditions: Malignant Pleural Effusion
Interventions: DRUG: Bevacizumab|DRUG: Pulvis talci
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gait Adaptation for Stroke Patients With Augmented Reality
Status: UNKNOWN
Conditions: Stroke|Traumatic Brain Injury|Spinal Cord Injury
Interventions: DEVICE: Gait training with augmented reality|DEVICE: Standard training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary Brain Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: PROCEDURE: conventional surgery|RADIATION: iodine I 131 monoclonal antibody 81C6|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Implementation of Enhanced Recovery After Surgery Program (ERAS) in Colorectal Cancer Surgery, a Randomized Controlled Trial
Status: COMPLETED
Conditions: Cancer of Colon
Interventions: PROCEDURE: enhanced recovery after surgery program in colorectal cancer surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Single-Blind, Controlled Safety and Immunogenicity Study of Recombinant MVA Virus to Treat HIV Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: MVA-mBN32|BIOLOGICAL: IMVAMUNE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Personalized DBS for OCD Guided by Stereoencephalography Mapping
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder|OCD
Interventions: DEVICE: Deep Brain Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Perfecting Refraction in India With Superior Service Models
Status: COMPLETED
Conditions: Refractive Error
Interventions: OTHER: School Model|OTHER: Referral Model|OTHER: Referral Model + Cost Recovery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase 4 Study in the Elderly Patients With T2DM
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Elderly
Interventions: DRUG: Vildagliptin|DRUG: "Usual Care"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propofol Versus Midazolam and Fentanyl for Diagnostic and Screening Colonoscopy in Patients With Advanced Liver Disease
Status: UNKNOWN
Conditions: Liver Cirrhosis
Interventions: DRUG: Propofol VS. midazolam and fentanyl, endoscopies, liver diseases
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Study to Evaluate Efficacy and Safety of Qingzhu Granules in the Treatment of Acute Gouty Arthritis
Status: RECRUITING
Conditions: Gouty Arthritis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Electrical Acustimulation (TEA) for Gastroparesis
Status: RECRUITING
Conditions: Gastroparesis With Diabetes Mellitus
Interventions: DEVICE: transcutaneous electrical accustimulation at treatment point.|DEVICE: transcutaneous electrical accustimulation at sham point.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prospective Use of Real-time MRI
Status: COMPLETED
Conditions: Evaluate the Role of Real-time Imaging in Needle Placement|Evaluate the Workflow and Effectiveness of Realtime Imaging Versus Standard MR Imaging
Interventions: PROCEDURE: Real-time imaging for MRI-guided procedures
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beta-blockade With Landiolol in Out-of-hospital Cardiac Arrest
Status: RECRUITING
Conditions: Cardiac Arrest
Interventions: DRUG: Landiolol|DRUG: Sodium Chloride (NaCl) 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intensive Insulin Therapy in Non-diabetic Patients With Acute Myocardial Infarction and Hyperglycaemia
Status: COMPLETED
Conditions: Diabetes|Hyperglycemia|Acute Myocardial Infarction
Interventions: DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder
Status: RECRUITING
Conditions: CDKL5 Deficiency Disorder|Generalized Tonic Clonic Seizure|Epileptic Spasm|Refractory Seizures
Interventions: DRUG: ZX008 (Fenfluramine Hydrochloride)|DRUG: Matching ZX008 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Unloading Induced Effects on Local Glucose Uptake Into m. Soleus
Status: COMPLETED
Conditions: Local Glucose Uptake|Glucose Metabolism Disorders
Interventions: DIETARY_SUPPLEMENT: lupin protein|OTHER: Neuromuscular electrical stimulation|DEVICE: HEPHAISTOS unloading orthotic device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Construction and Preliminary Application of Mindfulness-based Emotional Regulation Intervention Scheme for Adolescents With Anxiety Disorder and Caregivers
Status: COMPLETED
Conditions: Anxiety|Mindfulness|Emotional Regulation
Interventions: BEHAVIORAL: Mindfulness-based emotional regulation intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Blood Donation on Hematological and Iron Indices and Detection of Autologous Blood Transfusion
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: PROCEDURE: Blood donation and blood transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Treatment of Melasma With Stabilized Kligman Preparation Associated or Not With Pulsed Dye Laser
Status: TERMINATED
Conditions: Melanosis
Interventions: PROCEDURE: pulsed dye laser treatment|DRUG: Kligman's Trio
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Metformin and Oral Hormonal Contraceptive in Adolescents With Polycystic Ovary Syndrome
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Placebo|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravenous Iron Supplementation on Celiac Disease Remission (IRONCEL)
Status: NOT_YET_RECRUITING
Conditions: Celiac Disease
Interventions: DRUG: Ferinject|DRUG: oral iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Conventional Adult Out-of-hospital Cardiopulmonary Resuscitation Against a Concept With Mechanical Chest Compressions and Simultaneous Defibrillation - LINC Study
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DEVICE: LUCAS|OTHER: Conventional manual resuscitation method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Actinic Keratoses of the Face With Imiquimod 3.75% Cream Followed by Photodynamic Therapy
Status: TERMINATED
Conditions: Actinic Keratosis
Interventions: DRUG: Photodynamic therapy|DRUG: Imiquimod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Critical Limb Ischemia Rapid Delivery by SurgWerks-CLI Kit and VXP System
Status: UNKNOWN
Conditions: Critical Limb Ischemia (CLI)
Interventions: BIOLOGICAL: Autologous Bone Marrow Concentrate (aBMC)|BIOLOGICAL: Placebo Control (diluted autologous peripheral blood)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple-dose,Double-blind,Placebo-controlled Study of Sodium Oxybate in Patients With Essential Tremor
Status: COMPLETED
Conditions: Essential Tremor
Interventions: DRUG: Sodium Oxybate|DRUG: Sodium Oxybate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-inflammatory Effect of Platelet-Rıch Fıbrın
Status: COMPLETED
Conditions: Surgical Complication|Pain, Postoperative|Edema Face
Interventions: OTHER: Platelet rich fibrin application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: What is the Optimal Antithrombotic Strategy in Patients With Atrial Fibrillation Undergoing PCI?
Status: RECRUITING
Conditions: Acute Coronary Syndrome|Myocardial Infarction|Atrial Fibrillation|Atrial Flutter|STEMI - ST Elevation Myocardial Infarction|NSTEMI - Non-ST Segment Elevation MI|Bleeding|Stroke|Stent Thrombosis|Embolism|Coronary Artery Disease
Interventions: DRUG: 30-day DAPT|DRUG: Guideline-directed therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Safety, Pharmacokinetics and Pharmacodynamics of DS-1150b in Healthy Subjects and Subjects With Type-2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: DS-1150b|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Low-molecular-weight Heparin (LMWH) Versus Unfractionated Heparin (UFH) in Pregnant Women With Recurrent Abortion Secondary to Antiphospholipid Syndrome
Status: COMPLETED
Conditions: Recurrent Abortion
Interventions: DRUG: enoxaparin 40mg plus low dose aspirin|DRUG: Heparin calcium5,000 U twice daily plus low dose aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing Impact of Loco-regional Treatment on Survival in Metastatic Breast Cancer at Presentation
Status: COMPLETED
Conditions: Cancer of the Breast
Interventions: PROCEDURE: Surgery for breast cancer|OTHER: No Loco-regional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of HPV Therapeutic Vaccine in HPV Infected Women With Normal Cytology or ASCUS/LSIL
Status: COMPLETED
Conditions: Genital Infection Viral|HUMAN PAPILLOMA VIRUS
Interventions: BIOLOGICAL: ProCervix|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-intensity Atorvastatin for Arteriovenous Fistula Failure (HAFF): A Feasibility Pilot Study
Status: WITHDRAWN
Conditions: Primary Arteriovenous Fistula Failure
Interventions: DRUG: Atorvastatin 40mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficacy and Tolerance of Low Doses of Ethosuximide in the Treatment of Peripheral Neuropathic Pain
Status: RECRUITING
Conditions: Peripheral Neuropathic Pain
Interventions: DRUG: Ethosuximide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety of Levocetirizine Versus Loratadine for Treatment of Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Rhinitis|Allergic|Seasonal
Interventions: DRUG: Levocetirizine dihydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Trauma Informed Treatment Algorithms for Novel Outcomes
Status: RECRUITING
Conditions: Post-Traumatic Stress Disorder
Interventions: BEHAVIORAL: Stabilization Techniques (ST)|BEHAVIORAL: Stabilization Techniques with Behavioral Activation (ST+BA)|BEHAVIORAL: Eye Movement Desensitization and Reprocessing (EMDR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Integrative Medicine Outpatient Clinical Setting for Post-COVID-19 Patients
Status: COMPLETED
Conditions: COVID-19|Fatigue
Interventions: BEHAVIORAL: outpatient clinic with multimodal integrative medicine and naturopathy for post-COVID-19 patients|OTHER: waiting group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radium-223 Dichloride and Abiraterone Acetate Compared to Placebo and Abiraterone Acetate for Men With Cancer of the Prostate When Medical or Surgical Castration Does Not Work and When the Cancer Has Spread to the Bone, Has Not Been Treated With Chemotherapy and is Causing no or Only Mild Symptoms
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: Radium-223 dichloride (Xofigo, BAY88-8223)|DRUG: Matching placebo (normal saline)|DRUG: Abiraterone|DRUG: Prednisone/Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Oral Hypoglycaemic Agents (OHA) for Combination With Insulin Glargine (Sulfonylurea vs. Metformin)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Glimepiride|DRUG: Metformin|DRUG: Insulin Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Postprandial Calcium Absorption of a Milk Derived Calcium Permeate - RENEW Acute Study
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DIETARY_SUPPLEMENT: Calcium Carbonate|DIETARY_SUPPLEMENT: Calcium Permeate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of JNJ-54767414 (Daratumumab) in Combination With Bortezomib and Dexamethasone (D-Vd) in Japanese Participants With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: JNJ-54767414 (Daratumumab)|DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT