pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Efficacy Evaluation of S (+) - Ketamine in Adults
Status: UNKNOWN
Conditions: Postoperative Pain|Adults|Anesthesia
Interventions: DRUG: Conventional therapy + S (+)-Ketamine|DRUG: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Near-Infrared Spectroscopy (NIRS) or Intramuscular Glucose Levels Detect Impaired Leg Compartment' Perfusion?
Status: NOT_YET_RECRUITING
Conditions: Compartment Syndromes
Interventions: DIAGNOSTIC_TEST: Near infrared spectroscopy (NIRS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Molecular Profiling and Dynamic Changes of ctDNA in Unresectable Locally Advanced NSCLC
Status: RECRUITING
Conditions: Lung Cancer|Stage III Lung Cancer|Unresectable Lung Carcinoma
Interventions: PROCEDURE: Sample collection|DIAGNOSTIC_TEST: Characterization of the tumoral tissue genomic alterations|DRUG: Chemoradiation treatment regimen and maintenance (if amenable)|DIAGNOSTIC_TEST: Genomic and methylation analysis in liquid biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase I SAD and MAD Clinical Trial of CNM-Au8 in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers - Male and Female
Interventions: OTHER: CNM-Au8|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: KneuroKnits: Participation and Anxiety in People With Neurological Conditions Participating in a Knitting Group
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Neurodevelopmental Disorders|Acquired Brain Injury|Physical Disability
Interventions: OTHER: KneuroKnits
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Gender and HIV Infection on Zidovudine and Lamivudine Pharmacokinetics
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: zidovudine 300mg and lamivudine 150mg as Combivir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Efficacy of N-acetyl-cysteine in the Treatment of Burning Mouth Syndrome
Status: UNKNOWN
Conditions: Burning Mouth Syndrome
Interventions: DIETARY_SUPPLEMENT: N-acetyl cysteine|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Olive Oil on Nipple Cracking, Nipple Pain and Maternal Satisfactions
Status: UNKNOWN
Conditions: Cracked Nipple During Lactation
Interventions: OTHER: olive oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Pediatric Subjects With Peanut Allergy to Evaluate Efficacy and Safety of Dupilumab as Adjunct to AR101 (Peanut Oral Immunotherapy)
Status: COMPLETED
Conditions: Peanut Allergy
Interventions: DRUG: Dupilumab|DRUG: Placebo matching dupilumab|DRUG: AR101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Decision Support Tool for Vancomycin Dosing in Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Gram-Positive Bacterial Infections|Vancomycin|Pharmacokinetics|Pharmacodynamics
Interventions: DEVICE: Computer Decision Support Tool Intervention Group|OTHER: Matched Historical Controls
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Schizoaffective Disorder Using Mifepristone
Status: TERMINATED
Conditions: Psychotic Disorders|Depressive Disorder, Major|Depressive Disorder
Interventions: DRUG: Mifepristone|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes in WHO Type I Anovulatory Women Using r-hFSH+r-hLH in a 2:1 Ratio or hMG-HP
Status: COMPLETED
Conditions: Hypogonadotropic Hypogonadism
Interventions: DRUG: Pergoveris: 150IU r-hFSH + 75IU r-hLH|DRUG: Menopur: HMG-HP (150 IU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melatonin Metabolism Abnormality in Patients With Schizophrenia or Schizoaffective Disorder Treated With Olanzapine
Status: ACTIVE_NOT_RECRUITING
Conditions: Schizophrenia|Schizoaffective Disorder|Bipolar Disorder|Obesity|Metabolic Syndrome
Interventions: DRUG: olanzapine and melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Warm Compresses During the Second Stage and the Risk of Perineal Tears
Status: RECRUITING
Conditions: Perineum; Tear
Interventions: OTHER: The use of warm compresses and almond oil on the perineum during second stage|OTHER: Use of almond oil use (routine care) during second stage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Short-Term Oral Mifepristone for Central Serous Chorioretinopathy
Status: COMPLETED
Conditions: Central Serous Chorioretinopathy
Interventions: DRUG: Mifepristone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Clinical Study Using Pre-operative Simulation for Patients Undergoing Cochlear Implant
Status: WITHDRAWN
Conditions: Sensori-Neural Deafness
Interventions: DEVICE: Pre operative computer based cochlear implant surgical simulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Percutaneous Rupture of Zygapophyseal Joint Cysts
Status: COMPLETED
Conditions: Zygapophyseal Synovial Joint Cyst
Interventions: PROCEDURE: Percutaneous zygapophyseal cyst rupture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of Ceramic Laminate Veneers Made With Celtra Duo Press and IPS e.Max Press Ceramic
Status: COMPLETED
Conditions: Fracture|Tooth Discoloration
Interventions: PROCEDURE: celtra duo press|PROCEDURE: IPS e.max press
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Dexmedetomidine and Tracheal Intubation on Heart Rate Variability and QTc Interval
Status: COMPLETED
Conditions: Anesthesia, General
Interventions: DRUG: 0.5 mcg/kg IV infusion for 10 min, 1.0 mcg/kg IV infusion for 10 min
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: FASTT Telehealth Behavioral Support Service for Caregivers of Children With Developmental Delay or Disability
Status: COMPLETED
Conditions: Parent-Child Relations|Parenting|Child Behavior|Development Delay|Developmental Disability|Development Disorder, Child
Interventions: BEHAVIORAL: Family Advice and Support Text and Telephone (FASTT) program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Stereotactic Body Radiation Therapy (SBRT) Without Androgen Deprivation Therapy (ADT) in People With Unfavorable Intermediate-Risk Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: Stereotactic Body Radiation Therapy (SBRT)|RADIATION: Stereotactic Body Radiation Therapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Carbonated Drink
Status: COMPLETED
Conditions: Saliva Altered|Oral Hygiene|pH|Tooth Structure; Disorder
Interventions: OTHER: Group 1: no intervention|OTHER: Group 2: tap water gargle|DRUG: Group 3: 0.2% Chlorhexidine|OTHER: Group 4: Fluoridated tooth paste|OTHER: Group 5: Polyol containing gum|OTHER: Group 6: 1% sodium bicarbonate solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of LMA-Fastrach and I-gel for Blind Tracheal Intubation.
Status: COMPLETED
Conditions: General Anesthesia
Interventions: PROCEDURE: Tracheal intubation|PROCEDURE: Tracheal intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluocinolone Acetonide Intravitreal Inserts for Vein Occlusion in Retina
Status: TERMINATED
Conditions: Macular Edema|Retinal Vein Occlusion
Interventions: DRUG: Fluocinolone Acetonide|DRUG: Fluocinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nicotinic Modulation of Schizophrenia-like Information Processing Deficits in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Ketamine|DRUG: Nicotine|DRUG: Placebo|DRUG: Ketamine and Nicotine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective & Retrospective Study on Ectopic Lymphoid-like Structures in Chronic Skins of Autoimmune Bullous Diseases
Status: COMPLETED
Conditions: Autoimmune Bullous Disease
Interventions: PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of IW-3718 on the Pharmacokinetics of Oral Contraceptive, Levothyroxine, Glyburide, and Digoxin in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Microgestin®|DRUG: Levothyroxine|DRUG: Glyburide|DRUG: Digoxin|DRUG: IW-3718
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Skin Sensitization Potential of a New Nicotine Patch
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Nicotine Patch|DRUG: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Effect of Intermittent Hypoxia on Ischemia-reperfusion Injury in Healthy Individuals
Status: COMPLETED
Conditions: Intermittent Hypoxia
Interventions: BEHAVIORAL: Intermittent hypoxia|BEHAVIORAL: Intermittent normoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Conversion Therapy With Sintilimab Plus CAPOX in Patients With Unresectable Locally Advanced or Limited Metastatic Adenocarcinoma of the Stomach or Esophagogastric Junction
Status: UNKNOWN
Conditions: Gastroesophageal Junction Adenocarcinoma|Stomach Adenocarcinoma|Locally Advanced Unresectable Gastric Adenocarcinoma|Metastatic Gastric Cancer
Interventions: DRUG: sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prehabilitation to Overcome the Stress of Surgery: the Role of Nutrition in Enhancing Postoperative Functional Capacity
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: Whey Protein (Immunocal®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Family-Focused CBT Skills App and Standard Self Help Options for Childhood Anxiety
Status: COMPLETED
Conditions: Anxiety Disorders|Childhood Mental Disorder|Anxiety
Interventions: BEHAVIORAL: Anchors Away|BEHAVIORAL: Parent Enhanced Anchors Away|BEHAVIORAL: Self-Help E-Book
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Neurocognitive and Neurobehavioral Mechanisms of Change Following Psychological Treatment for Alcohol Use Disorder
Status: ACTIVE_NOT_RECRUITING
Conditions: Alcohol Use Disorder|Alcohol Abuse|Alcohol Drinking|Alcohol Dependence
Interventions: BEHAVIORAL: Cognitive Behavior Therapy|BEHAVIORAL: Mindfulness Based Relapse Prevention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Olaparib Maintenance With Pembrolizumab & Bevacizumab in BRCA Non-mutated Patients With Platinum-sensitive Recurrent Ovarian Cancer
Status: ENROLLING_BY_INVITATION
Conditions: Platinum-sensitive Recurrent BRCA Wild Type Ovarian Cancer
Interventions: DRUG: Olaparib-Pembrolizumab-Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ICP-192 in Patients With FGFR2-Rearranged Unresectable or Metastatic Intrahepatic Cholangiocarcinoma
Status: RECRUITING
Conditions: Intrahepatic Cholangiocarcinoma (ICC)
Interventions: DRUG: ICP-192
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b/2 Trial Evaluating Safety and Efficacy of CAPecitabine in Combination With Ni-rapaRIb in HER2-negative Advanced Breast canCEr
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Niraparib Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Stress Echocardiography in Post-Menopausal Women at Risk for Coronary Disease
Status: COMPLETED
Conditions: Coronary Artery Disease|Heart Disease
Interventions: DRUG: Perflutren Lipid Microsphere Injectable Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intensity-Modulated Radiation Therapy & Nivolumab for Recurrent or Second Primary Head & Neck Squamous Cell Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Head and Neck Squamous Cell Carcinoma
Interventions: RADIATION: IMRT|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of TissueGene-C to Degenerative Arthritis
Status: COMPLETED
Conditions: Degenerative Arthritis
Interventions: BIOLOGICAL: TissueGene-C|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk of QT-prolongation and Torsade de Pointes in Patients Treated With Acute Medication in a University Hospital
Status: COMPLETED
Conditions: Delirium|QT-prolongation
Interventions: DRUG: Haloperidol, azi/clari/erythromycin, levo/moxifloxacin, co-trimoxazole, vori/keto/flu/itraconazole, methadone, tacrolimus, sunitinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dasiglucagon in the Treatment of Postprandial Hypoglycaemia After Roux-en-Y Gastric Bypass
Status: COMPLETED
Conditions: Hyperinsulinemic Hypoglycemia|Postprandial Hypoglycemia
Interventions: DRUG: ZP4207|OTHER: Placebo (saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Closed Loop Spinal Cord Stimulation for Neuromodulation of Upper Motor Neuron Lesion Spasticity
Status: NOT_YET_RECRUITING
Conditions: Chronic Pain|Spasticity as Sequela of Stroke|Upper Motor Neuron Lesion
Interventions: DEVICE: Spinal Cord Stimulation- Closed loop
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Accuracy of LeFort I Osteotomy Fixation Using Two Plates Versus Four Plates Patient Specific Osteosynthesis
Status: COMPLETED
Conditions: Le Fort; I
Interventions: PROCEDURE: Maxillary orthognathic surgery using 4 patient specific osteosynthesis (4-Plates)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lymphedema Study for Arm or Leg Lymphedema
Status: COMPLETED
Conditions: Lymphedema
Interventions: DRUG: Ketoprofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Ductal Breast Carcinoma|Invasive Breast Carcinoma|Lobular Breast Carcinoma|Medullary Breast Carcinoma|Stage II Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer|Tubular Breast Carcinoma
Interventions: RADIATION: Radiation Therapy|OTHER: Questionnaire Administration|OTHER: Quality-of-Life Assessment|OTHER: Laboratory Biomarker Analysis|RADIATION: Hypofractionated Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of DPI-386 Nasal Gel for the Prevention of Nausea and Vomiting Associated With Motion
Status: COMPLETED
Conditions: Motion Sickness
Interventions: DRUG: DPI-386 Nasal Gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Accelerated Modulated Fractionation (SIB-IMRT) for Head and Neck District
Status: RECRUITING
Conditions: Carcinoma of the Head and Neck
Interventions: DRUG: Cetuximab plus Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Darifenacin and Physiotherapy for the Treatment of Overactive Bladder in Women
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: Darifenacin|PROCEDURE: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of a Corneal Pre-cut on Wound Architecture and Astigmatism in Cataract Surgery - a Pilot Study
Status: COMPLETED
Conditions: Cataract
Interventions: PROCEDURE: Corneal precut 600µm|PROCEDURE: Corneal stabincision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety Evaluation of Sintilimab or Placebo in Combination With XELOX as First Line Treatment in Patients With Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: Sintilimab|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Arm Study With a Nitinol Self-Expanding Paclitaxel-Eluting Stent to Treat BTK Arteries
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: Self-expandable drug eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Bronchoalveolar Lavage Fluid Driven Pathogenic Diagnosis of Lower Respiratory Tract Infections
Status: UNKNOWN
Conditions: Lower Respiratory Tract Infections
Interventions: PROCEDURE: bronchoalveolar lavage 120ml|PROCEDURE: bronchoalveolar lavage 60ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Cannabidiol Use to Reduce Cravings in Individuals With Opioid Use Disorder on Buprenorphine
Status: COMPLETED
Conditions: Opioid-use Disorder
Interventions: DRUG: Cannabidiol 600mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone to Prevent Oral Chronic Graft-versus-Host Disease
Status: COMPLETED
Conditions: Graft vs Host Disease
Interventions: DRUG: Topical Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Weight Loss Plus Omega-3 Fatty Acids or Placebo in High Risk Women
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DIETARY_SUPPLEMENT: Omega-3 Fatty Acids|OTHER: Placebo Capsule|OTHER: Diet and Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Continuous Glycemia Monitoring in Perioperative Period in Patients Undergoing Total Knee or Hip Arthroplasty
Status: UNKNOWN
Conditions: Osteoarthritis, Knee|Osteoarthritis, Hip|Hyperglycemia|Diabetes Mellitus, Type 2
Interventions: DEVICE: Continuous glycemia measuring device (Dexcom) implantation into the subcutaneous tissue
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial Investigating the Effect of Semaglutide on Energy Intake, Appetite Sensations, Postprandial Glucose and Triglyceride Metabolism and Gastric Emptying in Obese Subjects Compared With Placebo
Status: COMPLETED
Conditions: Diabetes|Metabolism and Nutrition Disorder|Obesity
Interventions: DRUG: semaglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of A COVID-19 Vaccine Named Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector)
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector)|BIOLOGICAL: Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) -placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Intravenous Iron on Musculoskeletal Function in Older Adults
Status: NOT_YET_RECRUITING
Conditions: Iron Deficiency Anemia
Interventions: DRUG: Ferinject|DRUG: Ferrous Sulfate 200 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multicentre Phase III Erythropoietic Protoporphyria Study
Status: COMPLETED
Conditions: Erythropoietic Protoporphyria
Interventions: DRUG: Afamelanotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Protocol Comparing a Home Rehabilitation Program Versus e-Health Program in Low Back Pain
Status: COMPLETED
Conditions: Chronic Low-back Pain
Interventions: OTHER: Home Rehabilitation Program|OTHER: e-Health program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of fNIRS-based Neurofeedback Training on Balance and Gait in Parkinson's Disease
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease|Movement Disorder, Functional
Interventions: OTHER: fNIRS-based neurofeedback with motor imagery|OTHER: Kinesthetic motor imagery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Combining Acitretin and Efalizumab in the Therapy of Chronic Plaque Psoriasis
Status: UNKNOWN
Conditions: Chronic Plaque Psoriasis
Interventions: DRUG: efalizumab plus placebo|DRUG: efalizumab plus acitretin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The METRIC Study Protocol
Status: RECRUITING
Conditions: Chronic Low-back Pain
Interventions: PROCEDURE: lumbar spinal manipulative therapy|PROCEDURE: sham spinal manipulative therapy|PROCEDURE: full spine spinal manipulative therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Progressive Relaxation Exercise Performed Before Coronary Angiography
Status: NOT_YET_RECRUITING
Conditions: Coronary Angiography|Progressive Relaxation Exercise|Nursing
Interventions: OTHER: Progressive relaxation exercise before coronary angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study Evaluating A 13-Valent Pneumococcal Conjugate Vaccine Administered to Infants in Taiwan
Status: COMPLETED
Conditions: Vaccines|Pneumococcal Conjugate Vaccine
Interventions: BIOLOGICAL: 13-valent pneumococcal conjugate vaccine (13vPnC)|BIOLOGICAL: 7-valent pneumococcal conjugate vaccine (7vPnC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of a Yeast Fermentate (EpiCor) Supplement on Cold or Flu Symptoms in Healthy Children
Status: COMPLETED
Conditions: Signs and Symptoms, Respiratory
Interventions: DIETARY_SUPPLEMENT: EpiCor|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brighter Bites & UT Physicians Produce Rx Program
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity, Childhood
Interventions: OTHER: Arm 1|OTHER: Arm 2|OTHER: Arm 3|OTHER: Brighter Bites app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Mechanism of rTMS in Children With ASD: an Open-label Clinical Trial(Ⅱ)
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DEVICE: repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Effect of Aerobic Training on Insulin Sensitivity on Diabetic Patients During Tobacco Cessation
Status: RECRUITING
Conditions: Diabetes
Interventions: BEHAVIORAL: aerobic training , tobacco cessation and nutritional advices|BEHAVIORAL: tobacco cessation and nutritional advices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HRD and Resistance to PAPPi in EOC Patients
Status: RECRUITING
Conditions: Epithelial Ovarian Cancer|Homologous Recombination Deficiency|Homologous Recombination Repair Gene Mutation|Poly(ADP-ribose) Polymerase Inhibitor|Drug Resistance|Progression-free Survival|Overall Survival
Interventions: GENETIC: Testing of homologous recombination deficiency
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fluorouracil Plus Interferon Alfa in Treating Patients With Advanced Metastatic Carcinoid Tumors
Status: COMPLETED
Conditions: Gastrointestinal Carcinoid Tumor|Lung Cancer
Interventions: BIOLOGICAL: recombinant interferon alfa|DRUG: fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Cognitive Remediation in ADHD Children : Comparison Between Three Therapeutic Strategies : Cognitive Remediation With a Virtual Classroom Software and Methylphenidate and Supportive Psychotherapy
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: Methylphenidate|DEVICE: cognitive remediation|BEHAVIORAL: supportive psychotherapy|OTHER: neuropsychological tests
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Erythrocyte Omega-3 Fatty Acid Content in Elite Athletes
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: 2 Gums|DIETARY_SUPPLEMENT: 3 Gums
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Androgen for Leydig Cell Proliferation
Status: COMPLETED
Conditions: Klinefelter Syndrome|Hypergonadotropic Hypogonadism|Hypergonadotropic Azospermia|Hypergonadotropic Cryptozoospermia
Interventions: DRUG: Testosterone undecanoate|DRUG: Castor Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Computerized Cognitive Training to Protect Cognitive Function Among Hypertension Patients
Status: NOT_YET_RECRUITING
Conditions: Mild Cognitive Impairment|Hypertension
Interventions: BEHAVIORAL: Multi-domain adaptive cognitive training|BEHAVIORAL: Basic cognitive training with no difficulty change
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of the Pathophysiological and Functional State of the Knee Joint
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis, Knee|Cartilage Degeneration
Interventions: DIAGNOSTIC_TEST: Gait analysis, Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Etomidate Sedation in Gastric Endoscopic Submucosal Dissection
Status: RECRUITING
Conditions: Sedation Complication|Endoscopic Submucosal Dissection|Esophagogastroduodenoscopy
Interventions: DRUG: Etomidate Injection|DRUG: Propofol Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Low Level Laser Therapy in the Dorsal Root Ganglion in the Treatment of Chronic Low Back Pain
Status: COMPLETED
Conditions: Pain|Low Back Pain|Nociceptive Pain|Neuropathic Pain|Low Level Laser Therapy
Interventions: PROCEDURE: Laser|PROCEDURE: Drug: Lidocaine|PROCEDURE: Radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of add-on Therapy With N-Acetylcysteine in Resistant Obsessive-compulsive Disorder
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: N-Acetylcysteine (NAC)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation in Stroke Motor Rehabilitation Treatment
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: DEVICE: Repetitive TMS over contralateral premotor cortex.|DEVICE: Repetitive TMS over ipsilateral premotor cortex.|DEVICE: Repetitive TMS over contralateral primary motor cortex.|DEVICE: Sham Repetitive TMS over contralateral premotor cortex.|DEVICE: Single TMS over extensor carpi ulnaris spot of motor cortex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Exeporfinium Chloride (XF-73) Gel on Nasal S.Aureus in Patients at Risk of Post-op Staphylococcal Infection
Status: COMPLETED
Conditions: Staphylococcal Infections|Surgical Site Infection
Interventions: DRUG: XF-73|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: PD-1 Inhibitor Plus GP as Neoadjuvant Therapy for Locoregionally Advanced Nasopharyngeal Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Nasopharyngeal Carcinoma|Neoadjuvant Therapy|PD-1 Inhibitor
Interventions: DRUG: PD-1 inhibitor+GP|DRUG: GP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: N-MOmentum: A Clinical Research Study of Inebilizumab in Neuromyelitis Optica Spectrum Disorders
Status: COMPLETED
Conditions: Neuromyelitis Optica and Neuromyelitis Optica Spectrum Disorders
Interventions: DRUG: Inebilizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retina is a Marker for Cerebrovascular Heath
Status: RECRUITING
Conditions: Cerebral Small Vessel Diseases|Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy|Cerebral Microbleeding|Sporadic White Matter Disease
Interventions: DRUG: Cilostazol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: QUILT-3.072: NANT Hepatocellular Carcinoma (HCC) Vaccine
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma Non-resectable|Hepatocellular Carcinoma Recurrent
Interventions: BIOLOGICAL: ETBX-011|BIOLOGICAL: GI-4000|BIOLOGICAL: haNK for infusion|BIOLOGICAL: avelumab|DRUG: Capecitabine|DRUG: Cyclophosphamide|DRUG: 5-Fluorouracil|DRUG: Leucovorin|DRUG: nab-Paclitaxel|DRUG: Sorafenib|PROCEDURE: SBRT|BIOLOGICAL: Aldoxorubicin hydrochloride|BIOLOGICAL: ETBX-051|BIOLOGICAL: ETBX-061|BIOLOGICAL: GI-6207|BIOLOGICAL: GI-6301|DRUG: Cetuximab|BIOLOGICAL: N-803
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebrospinal Fluid Hemoglobin to Monitor for Aneurysmal Subarachnoid Hemorrhage Related Secondary Brain Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Subarachnoid Hemorrhage, Aneurysmal|Vasospasm|Delayed Cerebral Ischemia|Delayed Ischemic Neurological Deficit
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the National Randomized Proton Pump Inhibitor De-prescribing (RaPPID) Program
Status: COMPLETED
Conditions: Proton Pump Inhibitors
Interventions: BEHAVIORAL: PPI De-prescribing Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prevention of HIV/AIDS and STDs in Women Over Fifty
Status: COMPLETED
Conditions: Hiv|Sexually Transmitted Diseases|Aging
Interventions: BEHAVIORAL: safe sex and HIV/STD prevention education via a website|OTHER: written materials on safe sex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nurse-led Mind-body Intervention on Sexual Health for Breast Cancer Survivors
Status: NOT_YET_RECRUITING
Conditions: Women's Health: Neoplasm of Breast|Menopause, Premature|Body Image|Sexual Dysfunction|Cancer, Breast
Interventions: BEHAVIORAL: EMBRACE (Empowerment through Mind and Body Reclamation After Cancer Experience)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dietary Supplementation Effects on Bowel Movement Frequency and Intestinal Biological Markers in Seniors Presenting Slowed Intestinal Transit
Status: COMPLETED
Conditions: Constipation
Interventions: DIETARY_SUPPLEMENT: VES002|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Efficacy and Safety of VIT-2763 (Vamifeport) in Subjects With Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: VIT-2763 120 mg|DRUG: VIT-2763 360 mg|DRUG: VIT-2763 240 mg|DRUG: Placebo BID|DRUG: Placebo TID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Neck Squamous Cell Carcinoma of Unknown Primary|Recurrent Hypopharyngeal Squamous Cell Carcinoma|Recurrent Laryngeal Squamous Cell Carcinoma|Recurrent Laryngeal Verrucous Carcinoma|Recurrent Lip and Oral Cavity Squamous Cell Carcinoma|Recurrent Neck Squamous Cell Carcinoma of Unknown Primary|Recurrent Oral Cavity Verrucous Carcinoma|Recurrent Oropharyngeal Squamous Cell Carcinoma|Recurrent Salivary Gland Carcinoma|Recurrent Sinonasal Squamous Cell Carcinoma|Salivary Gland Squamous Cell Carcinoma|Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7|Stage IV Major Salivary Gland Cancer AJCC v7|Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7|Stage IVA Laryngeal Verrucous Carcinoma AJCC v7|Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7|Stage IVA Major Salivary Gland Cancer AJCC v7|Stage IVA Oral Cavity Cancer AJCC v6 and v7|Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVA Sinonasal Squamous Cell Carcinoma AJCC v7|Stage IVB Laryngeal Squamous Cell Carcinoma AJCC v7|Stage IVB Laryngeal Verrucous Carcinoma AJCC v7|Stage IVB Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7|Stage IVB Major Salivary Gland Cancer AJCC v7|Stage IVB Oral Cavity Cancer AJCC v6 and v7|Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVB Sinonasal Squamous Cell Carcinoma AJCC v7|Stage IVC Laryngeal Squamous Cell Carcinoma AJCC v7|Stage IVC Laryngeal Verrucous Carcinoma AJCC v7|Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7|Stage IVC Major Salivary Gland Cancer AJCC v7|Stage IVC Oral Cavity Cancer AJCC v6 and v7|Stage IVC Oropharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVC Sinonasal Squamous Cell Carcinoma AJCC v7|Tongue Carcinoma
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Docetaxel|DRUG: Fluorouracil|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxytocin and Affect Processing in Posttraumatic Stress Disorder
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder (PTSD)
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Yoga Therapy During Chemotherapy and Radiation Treatment for the Improvement of Physical and Emotional Well-Being in Patients With Stage IB2-IIIB Cervical Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Adenocarcinoma|Cervical Adenosquamous Carcinoma|Cervical Squamous Cell Carcinoma, Not Otherwise Specified|Stage IB2 Cervical Cancer FIGO 2018|Stage IB3 Cervical Cancer FIGO 2018|Stage II Cervical Cancer FIGO 2018|Stage IIA Cervical Cancer FIGO 2018|Stage IIA1 Cervical Cancer FIGO 2018|Stage IIA2 Cervical Cancer FIGO 2018|Stage IIB Cervical Cancer FIGO 2018|Stage IIIA Cervical Cancer FIGO 2018|Stage IIIB Cervical Cancer FIGO 2018
Interventions: OTHER: Media Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|OTHER: Survey Administration|PROCEDURE: Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 2 Study to Evaluate the Oral Combination of Ixazomib (MLN9708) With Cyclophosphamide and Dexamethasone in Patients With Newly Diagnosed or Relapsed and/or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Cyclophosphamide|DRUG: Ixazomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacodynamic and Pharmacokinetics of 7.5, 10, 12.5 or 15 mg NRL001 in a 2 g Suppository for 14 Days
Status: COMPLETED
Conditions: Fecal Incontinence
Interventions: DRUG: NRL001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Saliva Substitutes on Dental Hard Tissues in Situ
Status: TERMINATED
Conditions: Hyposalivation
Interventions: DRUG: Glandosane|DEVICE: Saliva natura
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First-in-Human, Single- and Multiple-Ascending Dose and Food-Effect Study of BGB-23339 in Healthy Participants
Status: COMPLETED
Conditions: Not Determined
Interventions: DRUG: BGB-23339|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Losmapimod in Treating Participants With Facioscapulohumeral Muscular Dystrophy (FSHD) (REACH)
Status: ACTIVE_NOT_RECRUITING
Conditions: Facioscapulohumeral Muscular Dystrophy (FSHD)
Interventions: DRUG: Losmapimod|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Neoadjuvant DC-T in Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Pegylated liposomal doxorubicin|DRUG: Cyclophosphamide|DRUG: Epirubicin|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluocinolone Acetonide Intravitreal Implant 0.18 mg in the Treatment of Chronic Non-Infectious Posterior Segment Uveitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Uveitis, Posterior
Interventions: DRUG: Fluocinolone Acetonide Intravitreal Implant 0.18 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Topical 85% TCA in the Treatment of LSIL After Low-grade Abnormality of Screening Test: a Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Cervical Intraepithelial Neoplasia|Trichloroacetic Acid
Interventions: DRUG: 85%TCA topical application|DRUG: 3% acetic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Performance Evaluation of the LumiraDX SARS-CoV-2 Ag Ultra and LumiraDX SARS-CoV-2 & Flu A/B Tests at Point of Care (POC) Sites
Status: SUSPENDED
Conditions: SARS-CoV-2|Influenza A|Influenza B|COVID-19
Interventions: DIAGNOSTIC_TEST: LumiraDx SARS-CoV-2 Ag Ultra|DIAGNOSTIC_TEST: LumiraDx SARS-CoV-2 & Flu A/B
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Obalon Balloon System Pivotal IDE (SMART) Trial
Status: COMPLETED
Conditions: Obesity
Interventions: DEVICE: Obalon Intragastric Balloons|DEVICE: Sham Device|BEHAVIORAL: Nutrition and Lifestyle Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Diabetes Education Program Based on Tailored Interventions (Edep-Ti Study)
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Therapeutic Education Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vitamin K1 in the Treatment of Spontaneous Intracerebral Hemorrhage
Status: UNKNOWN
Conditions: Intracerebral Haemorrhage in Cerebellum
Interventions: DRUG: Vitamin K 1|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimized Erythropoietin (EPO) Treatment
Status: COMPLETED
Conditions: Neonatal Anemia
Interventions: DRUG: Epoetin Alpha|DRUG: Biotinylated Red Blood Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Blood Levels and Safety of AZD9291 in Patients With Advanced Solid Tumours and Normal Liver Function or Mild or Moderate Liver Impairment
Status: COMPLETED
Conditions: Solid Tumours
Interventions: DRUG: AZD9291 tablet dosing|PROCEDURE: Pharmacokinetic sampling - AZD9291|PROCEDURE: Pharmacokinetic sampling - AZ5140 and AZ7550
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Trial Comparing Nonacog Beta Pegol (N9-GP) and ALPROLIX® in Patients With Haemophilia B
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia B
Interventions: DRUG: N9-GP|DRUG: ALPROLIX®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT