pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Quantitative Evaluation of Metastatic Lymph Nodes With Dynamic 18F-FDG PET/CT in Patients With ESCC
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma|Positron Emission Tomography
Interventions: DIAGNOSTIC_TEST: Dynamic PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The PREVENT Trial: a Pragmatic Cluster Randomized Controlled Trial of a Multifaceted Fracture Prevention Model for Long-term Care
Status: RECRUITING
Conditions: Fracture|Fractures, Hip|Osteoporosis
Interventions: BEHAVIORAL: PREVENT Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Real-World Study of Pegylated Interferon In Nucleoside-treated Patients With Chronic Hepatitis B
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: Pegylated interferon|DRUG: Entecavir|DRUG: Tenofovir disoproxil fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Right Ventricular Resynchronization Therapy
Status: UNKNOWN
Conditions: Right Ventricular Failure|Chronic Thromboembolic Pulmonary Hypertension|Pulmonary Hypertension
Interventions: DEVICE: Implantation of 3-chamber pacemaker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation in Episodic Migraine (Magnet-EM)
Status: COMPLETED
Conditions: Migraine
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation.|DEVICE: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of BI 10773 and Linagliptin in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 10773|DRUG: Linagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Exercise on Endothelial Injury in Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension|Healthy
Interventions: OTHER: AEROBIC|OTHER: RESISTANCE|OTHER: COMBINED
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Slow Breathing Exercise Applied to Patients on Pulse, Blood Pressure and Quality of Life
Status: RECRUITING
Conditions: Slow Breathing|Acute Myocardial Infarction
Interventions: BEHAVIORAL: Slow breathing exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Randomised Controlled Trial of the Use of Topical Metronidazole (10%) to Reduce Pain After Haemorrhoidectomy
Status: COMPLETED
Conditions: Haemorrhoidectomy
Interventions: DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Donor Lymphocyte Infusion After Allo-PBSCT for Patients With Very High-risk Hematologic Malignancies
Status: UNKNOWN
Conditions: Donor Lymphocyte Infusion|Peripheral Blood Stem Cell Transplantation|Relapse|Graft-versus-host Disease|Decitabine
Interventions: BIOLOGICAL: Prophylactic DLI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability & Pharmacokinetics (PK) of Co-administered Single Doses of OZ439 and Mefloquine (MQ) in Healthy Volunteers
Status: TERMINATED
Conditions: Malaria
Interventions: DRUG: OZ439 100mg|DRUG: OZ439 400mg|DRUG: MQ 250 mg, single dose|DRUG: MQ 750mg, single dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cabozantinib Treatment Prior to Cytoreductive Nephrectomy in Patients With Advanced or Metastatic Renal Cells Cancer
Status: TERMINATED
Conditions: Renal Cell Carcinoma Metastatic|Renal Cell Carcinoma Stage IV|Renal Cell Carcinoma Stage III
Interventions: DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel-coated Peripheral Stents Used in the Treatment of Femoropopliteal Stenoses
Status: COMPLETED
Conditions: Peripheral Arterial Disease (PAD)
Interventions: DEVICE: Zilver® Paclitaxel-Eluting Peripheral Stent|DEVICE: Zilver® Paclitaxel-Eluting Peripheral Stent with slower-dissolving polymer-free paclitaxel coating|DEVICE: Zilver® Paclitaxel-Eluting Peripheral Stent with higher-dose polymer-free paclitaxel coating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: How Does Task Loading in PICU Impact on Clinician Situational Awareness and Awareness of the Passage of Time?
Status: UNKNOWN
Conditions: Clinician Perception|Clinician Attention
Interventions: BEHAVIORAL: Technical task|BEHAVIORAL: Administrative task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Removal of Bacterial Spores in Adults on Skin
Status: COMPLETED
Conditions: General Skin Cleansing
Interventions: DRUG: Chlorhexidine Gluconate|COMBINATION_PRODUCT: HUBS with Hibiclens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Addressing Dementia Via Agitation-Centered Evaluation
Status: COMPLETED
Conditions: Agitation in Patients With Dementia of the Alzheimer's Type|Alzheimer Disease|Agitation,Psychomotor
Interventions: DRUG: AXS-05|DRUG: Bupropion|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Drug Interaction Potential of Napabucasin in Healthy Volunteers
Status: COMPLETED
Conditions: Drug-drug Interactions
Interventions: DRUG: napabucasin|DRUG: cytochrome P450 (CYP450) probe drugs or BCRP transporter substrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of COVID-19 Patients Using Wharton's Jelly-Mesenchymal Stem Cells
Status: UNKNOWN
Conditions: Use of Stem Cells for COVID-19 Treatment
Interventions: BIOLOGICAL: WJ-MSCs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-treatment Effects of Ivermectin (IVM) or Diethylcarbamazine (DEC) in Loiasis
Status: COMPLETED
Conditions: Loiasis
Interventions: DRUG: Diethylcarbamazine|DRUG: Ivermectin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Liraglutide on Blood Glucose Control in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: rosiglitazone|DRUG: glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cognition and Health in Adolescents, Mindfulness as Prevention of Stress.
Status: UNKNOWN
Conditions: Stress|Complete Psychological Check Up|Sleep|Cognition - Other|Personality
Interventions: BEHAVIORAL: Mindfulness intervention|BEHAVIORAL: Music relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Ph 1-2 Study ADI-PEG 20 Plus FOLFOX in Subjects With Advanced GI Malignancies Focusing on Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Advanced Gastrointestinal (GI) Malignancies|Hepatocellular Carcinoma|Gastric Cancer|Colorectal Cancer
Interventions: DRUG: ADI-PEG 20 plus modified FOLFOX6
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: eValuating iDA Selection Ability. The VISA Study.
Status: ACTIVE_NOT_RECRUITING
Conditions: IVF|Infertility
Interventions: DEVICE: iDAScore®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transversus Thoracic Plane Block for Perioperative Analgesia in Cardiac Surgery
Status: NOT_YET_RECRUITING
Conditions: Transversus Thoracic Plane Block|Cardiac Surgery|Post Operative Pain
Interventions: PROCEDURE: Transversus Thoracic Plane Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I Clinical Study of VC005 Tablets in Subjects With Rheumatoid Arthritis.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: VC005 tablets|DRUG: VC005 Tablets Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Nimodipine to Prevent Mild Cognitive Impairment After Acute Ischemic Strokes
Status: UNKNOWN
Conditions: Stroke|Mild Cognitive Impairment
Interventions: DRUG: Nimodipine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Head-to-head Comparison of Single Versus Dual Antiplatelet Treatment Strategy After Percutaneous Left Atrial Appendage Closure: a Multicenter, Randomized Study
Status: UNKNOWN
Conditions: Left Atrial Appendage Occlusion|Antiplatelet Therapy
Interventions: DRUG: Aspirin 100mg|DRUG: Aspirin 100 mg OD plus clopidogrel 75 mg OD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardioprotective Effects of GLP-1 and Their Mechanisms
Status: COMPLETED
Conditions: Angina Pectoris
Interventions: DRUG: GLP-1 (7-36) amide|DRUG: Glibenclamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prescreening Study to Identify Potential Participants for ACDN-01 Clinical Trials
Status: RECRUITING
Conditions: Stargardt Disease|Stargardt Disease 1|Cone Rod Dystrophy|Juvenile Macular Degeneration
Interventions: DIAGNOSTIC_TEST: Prescreening Assessments
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial of Immunotherapy Strategies in Metastatic Hormone-sensitive Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Hormone-sensitive Prostate Cancer
Interventions: DRUG: Ipilimumab 5 MG/ML|DRUG: Nivolumab 10 MG/ML|DRUG: Docetaxel|DRUG: ADT (androgen deprivation therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Switch to Oral Antibiotics in Gram-negative Bacteremia
Status: COMPLETED
Conditions: Escherichia Coli Bacteremia|Klebsiella Bacteraemia|Enterobacter Bacteraemia|Serratia Bacteraemia|Citrobacter Bacteraemia|Proteus Bacteraemia
Interventions: OTHER: Step down to oral antimicrobial therapy|OTHER: IV antimicrobial therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Fluid Responsiveness in ICU Patients Using VTI and Trendelenburg Positioning
Status: RECRUITING
Conditions: Shock|Fluid Overload|Cardiac Output, Low
Interventions: DEVICE: Trendelenburg positioning VTI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Adjunctive Mild Hypothermia Therapy to Primary Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction Complicated With Shock: A Feasibility Study
Status: UNKNOWN
Conditions: Myocardial Infarction Complicated With Cardiogenic Shock
Interventions: PROCEDURE: Hypothermia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MAGE-A4ᶜ¹º³²T for Multi-Tumor
Status: ACTIVE_NOT_RECRUITING
Conditions: Urinary Bladder Cancer|Melanoma|Head and Neck Cancer|Ovarian Cancer|Non-Small Cell Lung Cancer|Esophageal Cancer|Gastric Cancer|Synovial Sarcoma|Myxoid Round Cell Liposarcoma|Gastroesophageal Junction
Interventions: GENETIC: Autologous genetically modified MAGE-A4ᶜ¹º³²T cells|RADIATION: Autologous genetically modified MAGE-A4c1032T cells combined with low dose radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DeliKet (Substudy of KetoNiFast Study ID 22-1398_1)
Status: NOT_YET_RECRUITING
Conditions: Delirium|Ketogenic Dieting|Nutrition, Healthy
Interventions: DIETARY_SUPPLEMENT: Cyclic enteral daytime feeding with ketogenic nighttime fasting and exogenous ketone salt supplementation (ß-hydroxybutyrate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Compressive Stockings Therapy After TKA
Status: TERMINATED
Conditions: Compliance of Wearing of Compressive Stockings|Total Knee Arthroplasty
Interventions: DEVICE: Compressive stockings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Hypersensitivity and Digital Radiographic Assessment of a Zinc Modified Versus a Conventional Glass Ionomer Cement in Deep Carious Lesion: Randomized Controlled Clinical Trial
Status: UNKNOWN
Conditions: Carious Dentin
Interventions: PROCEDURE: Partial caries removel techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Internet-based Self-help Treatment for Panic Disorder: Two Ways of Complementary Psychological Support
Status: COMPLETED
Conditions: Panic Disorder
Interventions: BEHAVIORAL: Scheduled support|BEHAVIORAL: Non-scheduled support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Treatment of Multiple Gingival Recession Using Modified Coronally Advanced Tunnel With Subepithelial Connective Tissue Graft Depending on the Positioning of the Graft
Status: RECRUITING
Conditions: Gingival Recession
Interventions: DEVICE: The tunnel technique for root coverage with CTG with inner side of the graft|DEVICE: The tunnel technique for root coverage with CTG with outer side of the graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Real-world Head-to-head Study of Dupilumab Versus Mepolizumab in Danish CRSwNP Patients
Status: RECRUITING
Conditions: Chronic Rhinosinusitis With Nasal Polyps|Asthma; Eosinophilic|Eosinophilia
Interventions: BIOLOGICAL: dupilumab|BIOLOGICAL: mepolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evolution of Thromboelastography During Tranexamic Acid Treatment
Status: COMPLETED
Conditions: Hematological Malignancies Treated With Intensive Chemotherapy
Interventions: DRUG: Tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: D-OCT for Detection and Subtyping of BCC: a Diagnostic Cohort Study
Status: NOT_YET_RECRUITING
Conditions: Basal Cell Carcinoma|Optical Coherence Tomography
Interventions: DEVICE: Vivosight Multi-beam Swept-Source Frequency Domain OCT scanner
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy Study of Clevidipine to Control Hypertension in Patients Admitted With Aneurysmal Subarachnoid Hemorrhage
Status: TERMINATED
Conditions: Subarachnoid Hemorrhage|Hypertension
Interventions: DRUG: Clevidipine butyrate injectable emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of PAC-14028 Cream in Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: PAC-14028 cream 1.0%|DRUG: PAC-14028 cream vehicle|DRUG: Elidel cream 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Assess the Everolimus-Eluting Coronary Stent System (PROMUS Element) for Coronary Revascularization
Status: UNKNOWN
Conditions: Ischemic Heart Disease|Coronary Artery Stenosis
Interventions: DEVICE: Angioplasty (PROMUS Element™, and Xience™ Prime stent)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pelvic Floor Dysfunction and Aerobic Training in Gynecological Cancer
Status: NOT_YET_RECRUITING
Conditions: Gynecologic Cancer|Pelvic Floor Disorders|Aerobic Exercise
Interventions: OTHER: PFMT|OTHER: Aerobic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Micro-encapsulated Hepatocyte Intraperitoneal Transplantation in Liver Failure Adults
Status: NOT_YET_RECRUITING
Conditions: Acute-On-Chronic Liver Failure|Chronic Liver Failure
Interventions: BIOLOGICAL: a single course of micro-encapsulated hepatocytes intraperitoneal transplantation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Core Stabilization Exercises in Addition to Balance Exercises in Adult Hemophilia Patients on Balance, Quality of Life, Lower Limb Muscle Strength and Functional Level
Status: COMPLETED
Conditions: Hemophilia
Interventions: OTHER: Balance exercises|OTHER: Core Stabilization exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Mat Pilates Exercises in Individuals With Chronic Nonspecific Low Back Pain
Status: COMPLETED
Conditions: Nonspecific Chronic Low Back Pain|Chronic Low Back Pain
Interventions: OTHER: Pilates Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IMPlementation of Evidence Based Facility and Community Interventions to Reduce the Treatment Gap for depRESSion
Status: RECRUITING
Conditions: Depression
Interventions: BEHAVIORAL: Community Intervention|BEHAVIORAL: Healthy Activity Program (HAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Timing of Dexamethasone Administration on Pain Scores and Quality of Recovery in Cesarean Section.
Status: COMPLETED
Conditions: Pregnancy
Interventions: DRUG: Control|DRUG: Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Preliminary Efficacy of KRC-01
Status: NOT_YET_RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: KRC-01|RADIATION: External Beam Radiation Therapy|DRUG: cisplatin|RADIATION: brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate ITCA 650 Compared to Glimepiride as Add on Therapy for the Treatment of Type 2 Diabetes
Status: WITHDRAWN
Conditions: Type 2 Diabetes
Interventions: DRUG: ITCA 650|DRUG: glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First-in-human Study of PRTH-101 Monotherapy +/- Pembrolizumab in Subjects With Advanced Malignancies
Status: RECRUITING
Conditions: Advanced or Metastatic Solid Tumors
Interventions: BIOLOGICAL: PRTH-101|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Time-Point Study to Evaluate the ConforMIS iTotal® (CR) Knee Versus Off-the-Shelf
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: ConforMIS Total Knee Replacement System|DEVICE: Off-the-Shelf Knee Replacement System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study of the Use of a Portable Cranial Scanner in Intensive Care for Cerebro-injured Patients
Status: COMPLETED
Conditions: Craniocerebral Trauma
Interventions: PROCEDURE: portable scanner|PROCEDURE: fixed scanner
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Programmed Intermittent Epidural Bolus for Labor Analgesia During First Stage of Labor-3
Status: COMPLETED
Conditions: Labor Pain
Interventions: DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adherence in Patients Receiving PegIntron Pen/Rebetol for Hepatitis C in Conjunction With a Patient Assistance Program (Study P04281)(COMPLETED)
Status: COMPLETED
Conditions: Hepatitis C, Chronic|Hepacivirus
Interventions: BIOLOGICAL: Peginterferon alfa-2b (SCH 54031)|DRUG: Ribavirin (SCH 18908)|BEHAVIORAL: Patient assistance program
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Budesonide Versus Placebo for the Treatment of Lymphocytic Colitis
Status: TERMINATED
Conditions: Lymphocytic Colitis|Diarrhea
Interventions: OTHER: Placebo|DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Galantamine and CBT4CBT Pilot to Prevent Relapse.
Status: COMPLETED
Conditions: Methadone or Buprenorphine Detoxoxification
Interventions: DRUG: MAT taper with galantamine|DRUG: MAT taper with placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Patient-reported Monitoring of Symptoms and Spirometry Via the patientMpower Platform in Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: OTHER: patientMpower platform|OTHER: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Axial Alignment in Patients Operated Using the Visionaire Patient Matched Cutting Blocks
Status: TERMINATED
Conditions: Osteoarthritis of the Knee
Interventions: PROCEDURE: Visionaire|PROCEDURE: Standard surgical technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Response Variability in Children With Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Methylphenidate|DRUG: placebo|DRUG: Methylphenidate|DRUG: Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer. (Sub-Study C)
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: vepdegestrant|DRUG: Samuraciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-Reported Outcome Questionnaire for Systemic Mastocytosis
Status: COMPLETED
Conditions: Aggressive Systemic Mastocytosis (ASM)|SM w Assoc Clonal Hema Non-mast Cell Lineage Disease (SM-AHNMD)|Mast Cell Leukemia (MCL)|Smoldering Systemic Mastocytosis (SSM)|Indolent Systemic Mastocytosis (ISM) ISM Subgroup Fully Recruited
Interventions: OTHER: Interview
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Compare hFSH-HP (Fostipur) and hMG-HP(Meriofert) in Patients With Polycystic Ovary Under a IVF/ICSI Cycle.
Status: TERMINATED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: hMG-HP|DRUG: hFSH-HP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Comparison of RCD Versus BCD in Newly Diagnosed Waldenström Macroglobulinemia
Status: UNKNOWN
Conditions: Waldenström Macroglobulinemia
Interventions: DRUG: Bortezomib|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Infrared Coagulator Ablation or Observation in Preventing Anal Cancer in HIV-Positive Patients With Anal Neoplasia
Status: COMPLETED
Conditions: Anal Cancer|Neoplasm of Uncertain Malignant Potential|Nonneoplastic Condition|Precancerous Condition
Interventions: OTHER: clinical observation|DEVICE: infrared photocoagulation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Evaluation of Chemically Cured Conventional Glass Ionomer After Light Emitting Diode Radiant Heat Enhancement
Status: COMPLETED
Conditions: High Caries Risk Patients
Interventions: OTHER: KetacTM Universal AplicapTM|OTHER: KetacTM Universal AplicapTM with light cure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Maribavir Pediatric Formulation in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Maribavir Commercial Tablet Formulation|DRUG: Maribavir Pediatric Powder-for-oral Suspension Formulation|DRUG: Rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOLFOX/Bevacizumab With Onartuzumab (MetMAb) Versus Placebo as First-Line Treatment in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: 5-FU|DRUG: FOLFOX regimen|DRUG: Placebo|DRUG: bevacizumab [Avastin]|DRUG: leucovorin|DRUG: onartuzumab [MetMAb]
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Restoration of Hip Biomechanical Parameters by CT Measurement Between the 3 Surgical Techniques: RSA/Minihip/THA - Hip Replacement: 3D Planning
Status: NOT_YET_RECRUITING
Conditions: Coxarthrosis
Interventions: PROCEDURE: hip arthroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CAMH PARTNERs Integrated Care Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Depression|Anxiety|Alcohol Drinking
Interventions: BEHAVIORAL: Intervention: Mental Health Technician|OTHER: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Glycemic Load of Meals on the Cognition and Mood of Older Adults
Status: COMPLETED
Conditions: Dementia
Interventions: DIETARY_SUPPLEMENT: Isomaltulose|DIETARY_SUPPLEMENT: Sucrose|DIETARY_SUPPLEMENT: Glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: DUET Study: A Clinical Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of Orally Administered TERN-501 as Monotherapy and in Combination With TERN-101 in Noncirrhotic Adults With Presumed Non-Alcoholic Steatohepatitis
Status: COMPLETED
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: DRUG: TERN-501|DRUG: TERN-101|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Empagliflozin And Linagliptin Tablets in Healthy Chinese Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Test Empagliflozin And Linagliptin Tablets|DRUG: Reference Empagliflozin And Linagliptin tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficiency Between I-gel Blind Intubation and I-gel Bronchoscopic Intubation During Resuscitation
Status: COMPLETED
Conditions: Heart Arrest
Interventions: DEVICE: Conventional endotracheal tube|DEVICE: Reinforced endotracheal tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clip Closure of Mucosal Defects After Endoscopic Mucosal Resection.
Status: COMPLETED
Conditions: Endoscopic Resection|Clip|Haemorrhage|Non-pedunculated Lesions
Interventions: DEVICE: Clip closure|PROCEDURE: No clip closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Impacts of a Combined Berry Extract Supplement on Vascular Function and Oxygen Utility Capacity in Young Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Berry extract|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Rivaroxaban Versus Apixaban in Cerebral Venous Thrombosis
Status: RECRUITING
Conditions: Cerebral Venous Thrombosis
Interventions: DRUG: Apixaban 5MG|DRUG: Rivaroxaban 20 MG Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction Study Assessing Effect of Itraconazole on PF-07321332/Ritonavir in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participant
Interventions: DRUG: PF-07321332/ritonavir|DRUG: Itraconazole|DRUG: PF-07321332/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: COVID19 SARS Vaccinations: Systemic Allergic Reactions to SARS-CoV-2 Vaccinations
Status: COMPLETED
Conditions: SARS-CoV Infection|COVID-19|Allergic Reaction|Mast Cell Disorder
Interventions: BIOLOGICAL: Moderna COVID-19 Vaccine|BIOLOGICAL: Pfizer-BioNTech COVID-19 Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Dose Responses of Efficacy and Safety of ASP0456 in Patient With Chronic Constipation
Status: COMPLETED
Conditions: Chronic Constipation
Interventions: DRUG: ASP0456|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Lung Clearance Index in Cystic Fibrosis (CF) Patients, Infected With P.Aeruginosa
Status: TERMINATED
Conditions: Chronic Lung Infection With Pseudomonas Aeruginosa in Cystic Fibrosis
Interventions: DRUG: TIS or TIP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Trans-Resveratrol in Endothelial Function in Hypertensive Patients
Status: COMPLETED
Conditions: Endothelial Dysfunction
Interventions: DIETARY_SUPPLEMENT: Trans-resveratrol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Tolerance of Inhaled Fentanyl Aerosol (25µg/Dose) in Chinese Patients With BTcP
Status: COMPLETED
Conditions: Breakthrough Cancer Pain
Interventions: DRUG: Inhaled fentanyl aerosol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study for the Efficacy and Safety of Ropeginterferon Alfa-2b in Adult COVID-19 Patients With Comorbidities
Status: NOT_YET_RECRUITING
Conditions: COVID-19
Interventions: DRUG: Ropeginterferon alfa-2b|PROCEDURE: SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-inflammatory Diet Consultation for Those With Neuromuscular Disability
Status: COMPLETED
Conditions: Inflammation|Spinal Cord Injuries|Multiple Sclerosis|Muscular Dystrophies|Diet Habit
Interventions: BEHAVIORAL: Mad Dog Dietary Consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ENERGI-F701 for Female Hair Loss Treatment
Status: COMPLETED
Conditions: Female Pattern Baldness|Hair Loss|Alopecia
Interventions: DRUG: ENERGI-F701|DRUG: Regaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Minocycline Gel for Inflammatory Lesions of Papulopustular Rosacea
Status: UNKNOWN
Conditions: Papulopustular Rosacea
Interventions: DRUG: minocycline topical gel|DRUG: topical gel vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility, Efficacy and Safety of IBS ® for Implantaiton in the PDA in Duct-dependent Cyanotic CHD
Status: UNKNOWN
Conditions: Patent Ductus Arteriosus|Duct-dependent Cyanotic Congenital Heart Disease
Interventions: DEVICE: Iron biocorrodable coronary scaffold system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Banded Mini Gastric Bypass Trial: A Prospective Randomized Controlled Trial
Status: RECRUITING
Conditions: Bariatric Surgery|Weight Loss|Comorbidities and Coexisting Conditions
Interventions: DEVICE: Placement of MiniMizer Gastric Ring|PROCEDURE: Normal MGB-OAGB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Antiviral Study of ACH-126, 443 (Beta-L-Fd4C) in the Treatment of Adults With Chronic Hepatitis B Infection.
Status: TERMINATED
Conditions: Chronic Hepatitis B
Interventions: DRUG: ACH-126, 443 (beta-L-Fd4C)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Therapeutic Effects of Melatonin by Inhibition of NLRP3 Inflammasome in COVID19 Patients
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Melatonin|DRUG: The usual treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness Study of CPI-613 and/or Gemcitabine to Treat Metastatic Pancreatic Cancer
Status: WITHDRAWN
Conditions: Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: CPI-613|DRUG: Gemcitabine|DRUG: Any non-gemcitabine chemotherapies or best supportive care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketamine for Combined Depression and Alcohol Use Disorder
Status: NOT_YET_RECRUITING
Conditions: Depression|Alcohol Use Disorder
Interventions: DRUG: Ketamine Hydrochloride|DRUG: Midazolam Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Core Gel Study of the Safety and Effectiveness of Mentor Round Low Bleed Silicone Gel-filled Mammary Prostheses
Status: COMPLETED
Conditions: Breast Reconstruction|Breast Augmentation|Breast Revision
Interventions: DEVICE: Mentor Round Low Bleed Gel-filled Mammary Protheses, both Siltex and Smooth Surface
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigate the Effect of AZD1656 on the Pharmacokinetics of Digoxin in Type 2 Diabetes Mellitus Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: AZD1656|DRUG: Digoxin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preference of Tegaserod vs. PEG 3350 in Patients With Constipation
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: Tegaserod and Polyethylene Glycol 3350
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo Microneedles in Healthy Volunteers (Part I) and Efficacy/Safety of Doxorubicin Microneedles in Basal Cell Cancer Subjects (Part II)
Status: ACTIVE_NOT_RECRUITING
Conditions: Basal Cell Carcinoma
Interventions: COMBINATION_PRODUCT: Doxorubicin-containing MNA|DRUG: Placebo-containing MNA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Dynamic Hyperinflation on the Left-ventricular Diastolic Function in Healthy Male Subjects
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: PROCEDURE: Metronome-paced tachypnea|PROCEDURE: Expiratory-stenosis breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Trial Evaluating Slow-Release Formulation TAXUS Paclitaxel-Eluting Coronary Stents to Treat De Novo Coronary Lesions
Status: COMPLETED
Conditions: Coronary Stenosis
Interventions: DEVICE: TAXUS Paclitaxel-Eluting Coronary Stent, Slow-Formulation|DEVICE: Express2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Paravertebral Block for Proximal Humeral Fracture Surgery
Status: COMPLETED
Conditions: Proximal Humeral Fracture
Interventions: PROCEDURE: T2 paravertebral block|PROCEDURE: interscalene brachial plexus block and superficial cervical plexus block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LAMP Detection of Malaria in PREGnancy (LAMPREG) Trial
Status: RECRUITING
Conditions: Malaria|Pregnancy Malaria|Malaria in Pregnancy
Interventions: DIAGNOSTIC_TEST: LAMP|DIAGNOSTIC_TEST: Microscopy/RDT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence Study to Assess Systemic Exposure of FP and SAL FDC From Different DPIs
Status: COMPLETED
Conditions: Asthma|COPD
Interventions: DRUG: MGR001|DRUG: Advair® Diskus®|DRUG: Seretide™ Accuhaler™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CM93 Treatment in Subjects With Epidermal Growth Factor Receptor (EGFR)-Modified Recurrent Glioblastoma (rGBM)
Status: NOT_YET_RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: CM93
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Supplements and Periodontal Wound Healing
Status: UNKNOWN
Conditions: Periodontitis
Interventions: DIETARY_SUPPLEMENT: Regenium|DIETARY_SUPPLEMENT: Placebo|PROCEDURE: Full Mouth Disinfection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating Non-invasive Brain Stimulation to Enhance Fluency in People Who Stutter
Status: COMPLETED
Conditions: Stuttering, Developmental
Interventions: BEHAVIORAL: Metronome-timed speech|DEVICE: Active tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assess the Non-inferiority of GSK Biologicals' Mencevax™ ACWY (Manufactured by a New Process) vs Mencevax™ ACWY (the Already Existing Vaccine in the Market) When Given as a Single Dose to Subjects Aged 2-30 Yrs
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: Mencevax ACWY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Modified T Cells, Chemotherapy, and Aldesleukin With or Without LV305 and CMB305 in Treating Participants With Advanced or Recurrent Sarcoma
Status: COMPLETED
Conditions: HLA-A*0201 Positive Cells Present|NY-ESO-1 Positive Tumor Cells Present|Recurrent Myxoid Liposarcoma|Recurrent Synovial Sarcoma
Interventions: BIOLOGICAL: Aldesleukin|BIOLOGICAL: Autologous NY-ESO-1-specific CD8-positive T Lymphocytes|DRUG: Cyclophosphamide|BIOLOGICAL: Dendritic Cell-targeting Lentiviral Vector ID-LV305
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Therapeutic Drug Monitoring and Dosing for Vancomycin in Young Infants With Infections (VANCAPP) (Part 2)
Status: NOT_YET_RECRUITING
Conditions: Sepsis|Infections|Bacteremia
Interventions: OTHER: First-dose trough dose adjustment calculator - using early TDM (first-dose trough) to determine an early dose adjustment if the predicted steady-state trough is outside of target range (10-20mg/L)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Gemcitabine and Herceptin Versus Xeloda and Herceptin in HER-2 (+) Metastatic Breast Cancer Patients
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Gemcitabine|DRUG: Herceptin|DRUG: Capecitabine (Xeloda)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Effect of Adalimumab on Response to Influenza Virus and Pneumococcal Vaccines in Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: adalimumab|BIOLOGICAL: placebo|BIOLOGICAL: adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lithium for Fracture Treatment: a Double Blind Randomized Controlled Trial (LiFT)
Status: RECRUITING
Conditions: Fractures
Interventions: DRUG: Lithium Carbonate|DRUG: Lactose Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interferon Alfa and Imatinib Mesylate in Treating Patients With Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: recombinant interferon alfa|DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pirtobrutinib (LOXO-305) and Venetoclax for the Treatment of Patients With CLL or SLL Resistant to Covalent BTKi
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Computed Tomography|DRUG: Pirtobrutinib|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Artefill® for Moderate to Severe Atrophic Acne Scar Correction
Status: COMPLETED
Conditions: Atrophic Acne Scar
Interventions: DRUG: Normal Saline|DEVICE: Artefill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT