pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: 4 vs 6 Implants in Totally Edentulous Patient in Maxilla With Ti. Cad-cam Framework
Status: ACTIVE_NOT_RECRUITING
Conditions: Edentulous Maxilla
Interventions: DEVICE: 4 vs 6 implant treatment in the maxilla
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Healthy for my Baby- RCT of a Lifestyle Intervention for Overweight Women in Preconception
Status: RECRUITING
Conditions: Overweight and Obesity|Pregnancy Complications|Health Behavior|Life Style|Preconception Care
Interventions: BEHAVIORAL: Healthy for my Baby|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Continuous Monitoring of Right Ventricular Function, Based on the Correlation Between the C-X Segment of the Central Venous Pressure Curve, and the Echocardiographic Evaluation of Right Ventricular Systolic Function
Status: COMPLETED
Conditions: Heart Surgery|Ultrasonography Right Ventricle Systolic Function
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: AVID100 in Advanced Epithelial Carcinomas
Status: TERMINATED
Conditions: Solid Tumor, Adult|Triple Negative Breast Cancer|Head and Neck Squamous Cell Carcinoma|Non Small Cell Lung Cancer
Interventions: DRUG: AVID100 IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Randomized Controlled Trial to Evaluate the Efficacy and Safety of Remifentanil Versus Nitrous Oxide in External Cephalic Version at Term in Singleton Pregnancy in Breech Presentation
Status: COMPLETED
Conditions: Non-cephalic Presentation|Inhalation of Nitrous Oxide|Pregnancy Complications|Complications; Cesarean Section|Fetus or Neonate Affected by External Version Before Labor
Interventions: DRUG: Remifentanil|DRUG: Nitrous Oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OCTA Analysis of Macular and Papillary Perfusion After Refractive Surgery in Myopes
Status: UNKNOWN
Conditions: Myopia|Perfusion; Complications
Interventions: PROCEDURE: Refractive surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Hormone Therapy With Arzoxifene Hydrochloride in Treating Women With Recurrent, Advanced, or Metastatic Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Cancer
Interventions: DRUG: arzoxifene hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Kontralateral Training in Patients With Bankart Lesion
Status: COMPLETED
Conditions: Strenght of Rotator Cuff Muscles
Interventions: OTHER: Control Group|OTHER: Isokinetic Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Docetaxel in Combination With Cisplatin and 5-Fluorouracil in Locally Advanced Squamous Cell Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Advanced Squamous Cell Carcinoma|Squamous Cell Carcinoma of Head and Neck|SSCHN
Interventions: DRUG: Docetaxel|DRUG: Cisplatin|DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Maximum Tolerated Dose (MTD) of PARPi 2X-121 Monotherapy and the MTD of Dovitinib in Combination With 2X-121 in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: 2X-121 and dovitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Norethindrone/Ethinyl Estradiol 0.4 mg/35 Mcg Chewable Tablets Under Non-Fasted Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Norethindrone/Ethinyl Estradiol|DRUG: FEMCON® Fe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Angiography Versus (vs) IVUS Optimisation
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: PROCEDURE: IVUS optimised DES implantation|PROCEDURE: angiographically guided DES implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Placebo-controlled Study to Evaluate Effects of E5555 on Renal Function Parameters and OCT2 Activity
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: E5555|DRUG: E5555
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Transcutaneous Vagus Nerve Stimulation (taVNS) in Individuals With Primary Dysmenorrhea
Status: ENROLLING_BY_INVITATION
Conditions: Dysmenorrhea Primary|Pain
Interventions: DEVICE: Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)|DEVICE: Sham Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Endoscopic Submucosal Dissection for Early Gastric Cancer
Status: UNKNOWN
Conditions: Endoscopic Submucosal Dissection|Early Gastric Cancer|Multi-center, Single-arm Clinical Trial|Historical Control Group|Quality of Life and Cost Analysis
Interventions: PROCEDURE: Endoscopic Submucosal Dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alveolar Recruitment Maneuvers, Intracerebral Hemodynamic and Oxygenation
Status: RECRUITING
Conditions: Cerebral Injuries|Acute Respiratory Distress Syndrome (ARDS)
Interventions: OTHER: alveolar recruitment maneuvers group 1|OTHER: alveolar recruitment maneuvers group 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Two Different Exercise Programs and Diet in Obese Subjects With NAFLD
Status: RECRUITING
Conditions: Obesity|NAFLD
Interventions: BEHAVIORAL: Aerobic Exercise and diet intervention|BEHAVIORAL: Hiit and diet intervention|BEHAVIORAL: Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brentuximab Vedotin Plus AD in Non-bulky Limited Stage Hodgkin Lymphoma
Status: COMPLETED
Conditions: Hodgkin Lymphoma
Interventions: DRUG: Brentuximab Vedotin|DRUG: Adriamycin|DRUG: Dacarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Curcumin Supplementation on Lipid Profile and Inflammatory Markers of Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Non Insulin Dependent Diabetes
Interventions: DIETARY_SUPPLEMENT: curcumin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Using Clinicopathomic Markers to Predict Neoadjuvant Chemotherapy Response in Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer|Invasive Ductal Breast Carcinoma|Invasive Lobular Breast Carcinoma
Interventions: DIAGNOSTIC_TEST: Radiomic, pathomic, and clinical markers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Efficacy of a Toothpaste on Hypersensitivity Reduction
Status: COMPLETED
Conditions: Hypersensitivity
Interventions: DEVICE: Arginine/Calcium Carbonate|DEVICE: Mint Prophy paste - Fluoride free
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chorioretinal Vascularization and Electrophysiological Changes After Carotid Revascularization
Status: RECRUITING
Conditions: Carotid Stenosis
Interventions: DIAGNOSTIC_TEST: Optical coherence tomography angiography and pattern electroretinogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Suprascapular Nerve Block in Addition to Intra-articular Corticosteroid Injection in Adhesive Capsulitis
Status: COMPLETED
Conditions: Adhesive Capsulitis of the Shoulder
Interventions: PROCEDURE: Ultrasound-guided IAI|PROCEDURE: Ultrasound-guided SSNB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of EVEGYN 600 mg/1000 mg/100 mg Vaginal Ovule
Status: UNKNOWN
Conditions: Bioavailability
Interventions: DRUG: EVEGYN 600 mg/1000 mg/100 mg Vaginal Ovule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Metastatic Gastrointestinal Cancers Treated With Tumor Infiltrating Lymphocytes in Which the Gene Encoding the Intracellular Immune Checkpoint CISH Is Inhibited Using CRISPR Genetic Engineering
Status: RECRUITING
Conditions: Gastrointestinal Epithelial Cancer|Gastrointestinal Neoplasms|Cancer of Gastrointestinal Tract|Cancer, Gastrointestinal|Gastrointestinal Cancer|Colo-rectal Cancer|Pancreatic Cancer|Gall Bladder Cancer|Colon Cancer|Esophageal Cancer|Stomach Cancer
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|BIOLOGICAL: Tumor-Infiltrating Lymphocytes (TIL)|DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Accuracy and Safety Study of FES PET/CT in Assessment of ER Status of Recurrent or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Recurrent Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: [18F]fluoroestradiol (FES)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: EUS Guided Coil Embolization for Primary Prophylaxis of Gastric Varices
Status: RECRUITING
Conditions: Gastric Varices Bleeding
Interventions: DEVICE: Endoscopic ultrasound placement of Coil and glue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Gemigliptin 50mg qd Added in Patients With Type 2 Diabetes Inadequately Controlled on Glimepiride and Metformin
Status: COMPLETED
Conditions: T2DM
Interventions: DRUG: Gemigliptin|DRUG: Gemigliptin placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Cooled and Monopolar Radiofrequency Ablation of the Geniculate Nerves for the Treatment of Chronic Osteoarthritic Knee Pain
Status: TERMINATED
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: Genicular nerve radiofrequency ablation|DEVICE: Pain Management Radiofrequency Kit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sintilimab in Combination With Chemotherapy in Neoadjuvant Treatment of Potentially Resectable Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Sintilimab|DRUG: Liposomal Paclitaxel + Cisplatin + S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phonophoresis Versus Low-Level Laser on Dequervain
Status: COMPLETED
Conditions: de Quervain Tenosynovitis
Interventions: DEVICE: phonophoresis|DEVICE: Low level laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Paclitaxel Combined With Apatinib and Adebrelimab in Gastric/Gastroesophageal Junction Adenocarcinoma
Status: RECRUITING
Conditions: Gastric/Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Paclitaxel for injection (albumin-bound)|DRUG: Adebrelimab|DRUG: Apatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating the Safety & Efficacy of Intra-Tumoral Ipilimumab in Combination With Intra-venous Nivolumab in Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Stage III/IV Melanoma
Interventions: DRUG: Ipilimumab IT|DRUG: Ipilimumab IV|DRUG: Nivolumab IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Low Furanocoumarin Grapefruit Hybrid Juice Consumption on Midazolam Pharmacokinetics
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: OTHER: Low furanocoumarin hybrid grapefruit juice|OTHER: Regular grapefruit juice|OTHER: Water (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Gemcitabine With or Without Docetaxel as Second-Line Therapy in Treating Patients With Metastatic or Relapsed, Unresectable Uterine or Soft Tissue Leiomyosarcoma
Status: COMPLETED
Conditions: Sarcoma
Interventions: DRUG: docetaxel|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monitoring Radiobiological Effects in Thoracic Malignancy by Using Myocardial Perfusion Scan
Status: UNKNOWN
Conditions: Thoracic Neoplasms|Late Effect of Radiation
Interventions: RADIATION: Thallium-201 Myocardial Perfusion Study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Long-term Results of Tonsillectomy in the Treatment of Obstructive Sleep Apnea in Adults
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Tonsillar Hypertrophy|Sleep Apnea Syndromes
Interventions: DEVICE: Polysomnography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Timing of Hypertonic Saline Inhalation Relative to Airways Clearance in Cystic Fibrosis
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: PROCEDURE: Airways clearance and Hypertonic saline inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dual Site-dual Channel Non-invasive Brain Stimulation for Motor Function in Stroke Patients
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: M1 stimulation|DEVICE: PMC stimulation|DEVICE: aIPS stimulation|BEHAVIORAL: hand motor task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Therapy In Status Epilepticus
Status: ACTIVE_NOT_RECRUITING
Conditions: Status Epilepticus
Interventions: DRUG: Ganaxolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Evaluation of Alirocumab (SAR236553/REGN727) When Co-administered With High Dose of Atorvastatin in Patients With Primary Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Alirocumab|DRUG: Placebo (for alirocumab)|DRUG: Atorvastatin|DRUG: Placebo (for atorvastatin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the eFficacy, the Onset-of-Action and the Safety of Tot'héma® in Adults With Moderate Iron Deficiency Anaemia
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: TOT'HEMA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Predict Efficacy by Detecting Circulating Endothelial Cell Subsets and Blood Perfusion Parameters Changes in Vivo Tumor in Study of QL1101 and Avastin® in Patients With Non-squamous Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: QL1101|DRUG: Avastin®|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Prilosec OTC® Versus Zegerid® for Gastric Acid Suppression
Status: COMPLETED
Conditions: Normal Healthy Subject Population
Interventions: DRUG: Zegerid®|DRUG: Prilosec OTC®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose:
Clinical trial: Screening Wizard- Phase 2
Status: COMPLETED
Conditions: Depression|Suicidal Ideation
Interventions: BEHAVIORAL: "screening as usual"|BEHAVIORAL: Screening Wizard 2.0|BEHAVIORAL: Screening Wizard 2.0 + SOVA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Vinorelbine Oral Plus Capecitabine Combination In Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Vinorelbine oral|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coronally Advanced Flap With Two Different Techniques for the Treatment of Multiple Gingival Recessions
Status: COMPLETED
Conditions: Gingival Diseases
Interventions: PROCEDURE: Horizontal incisions|PROCEDURE: Oblique incisions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes in Pediatric Obsessive-Compulsive Disorder
Status: RECRUITING
Conditions: Obsessive-compulsive Disorder
Interventions: BEHAVIORAL: Group-based family cognitive-behavioural therapy|OTHER: Waitlist
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study MLN2480 in Combination With MLN0128 or Alisertib, or Paclitaxel, or Cetuximab, or Irinotecan in Adult Participants With Advanced Nonhematologic Malignancies
Status: COMPLETED
Conditions: Advanced Nonhematologic Malignancies
Interventions: DRUG: MLN2480|DRUG: MLN0128|DRUG: Alisertib|DRUG: Paclitaxel|DRUG: Cetuximab|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dinalbuphine Ester (Naldebain) for Pain Management After Cesarean Section
Status: NOT_YET_RECRUITING
Conditions: Postsurgical Pain|Cesarean Section|Chronic Post-surgical Pain
Interventions: DRUG: Sebacoyl Dinalbuphine Ester|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD) and Preliminary Efficacy of VIT-2763 in β-thalassaemia
Status: COMPLETED
Conditions: Beta-Thalassemia|Non-transfusion-dependent Thalassemia
Interventions: DRUG: VIT-2763 once a day (QD)|DRUG: VIT-2763 twice a day (BID)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topotecan Hydrochloride or Cyclodextrin-Based Polymer-Camptothecin CRLX101 in Treating Patients With Recurrent Small Cell Lung Cancer
Status: TERMINATED
Conditions: Extensive Stage Small Cell Lung Cancer|Recurrent Small Cell Lung Cancer
Interventions: DRUG: topotecan hydrochloride|DRUG: cyclodextrin-based polymer-camptothecin CRLX101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravesical Adjuvant Electromotive Mitomycin-C
Status: COMPLETED
Conditions: Bladder Cancer TNM Staging Primary Tumor (T) Ta|Bladder Cancer TNM Staging Primary Tumor (T) T1|Bladder Cancer Transitional Cell Grade
Interventions: PROCEDURE: Trans-urethral resection|DRUG: intravesical passive diffusion mitomycin|DEVICE: intravesical electromotive mitomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intramedullary Nailing vs External Ring Fixation for the Treatment of Tibial Shaft Fractures
Status: COMPLETED
Conditions: Tibial Shaft Fracture
Interventions: PROCEDURE: Intramedullary Nailing|PROCEDURE: External Ring fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Tolerability and Efficacy of Oral E-B-FAHF-2 in Mild-to-Moderate Crohn's Disease
Status: RECRUITING
Conditions: Crohn's Disease
Interventions: DRUG: EBFAHF-2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-PD-1 Immunotherapy Combined With SBRT for Patients With Oligometastatic ESCC
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma|Oligometastatic Disease
Interventions: DRUG: PD-1 combined with SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immuno-pet iMaging resPonses administeRed Immune checkpoiNt inhibiTor
Status: NOT_YET_RECRUITING
Conditions: NSCLC
Interventions: DRUG: Sasanlimab|RADIATION: non-ablative radiotherapy|DRUG: [89Zr]Zr-crefmirlimab berdoxam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindfulness + tDCS to Reduce Urgency Incontinence in Women
Status: COMPLETED
Conditions: Urinary Incontinence, Urge
Interventions: DEVICE: Transcranial direct current stimulation|BEHAVIORAL: Mindfulness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk Factors for Developing a Blood Clot in Patients Who Are Undergoing Cancer Treatment for Newly Diagnosed Gliomas
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Thromboembolism
Interventions: OTHER: laboratory biomarker analysis|OTHER: physiologic testing|PROCEDURE: management of therapy complications
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Chemotherapy, Total Body Irradiation, and Donor Blood Stem Cell Transplant in Treating Patients With Primary or Secondary Myelofibrosis
Status: COMPLETED
Conditions: Primary Myelofibrosis|Secondary Myelofibrosis
Interventions: DRUG: Cyclophosphamide|BIOLOGICAL: Filgrastim|DRUG: Fludarabine Phosphate|PROCEDURE: Hematopoietic Cell Transplantation|DRUG: Melphalan|DRUG: Mycophenolate Mofetil|DRUG: Tacrolimus|RADIATION: Total-Body Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Two Endoscopic Treatments of Bleeding Internal Hemorrhoids:Band Ligation and Electrocoagulation Probe
Status: COMPLETED
Conditions: Hemorrhoids
Interventions: PROCEDURE: Rubber band ligation|PROCEDURE: Bipolar coagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Mecobalamin in the Prevention of Capecitabine Induced Hand Foot Syndrome
Status: RECRUITING
Conditions: Hand-foot Syndrome
Interventions: DRUG: Mecobalamin 5 MG Disintegrating Oral Tablet|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety of hLF1-11 for the Treatment of Infectious Complications Among HSCT Recipients
Status: WITHDRAWN
Conditions: Fungal Infection|Bacterial Infection
Interventions: DRUG: human lactoferrin (hLF1-11)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Sivelestat in Preventing Postoperative Acute Respiratory Distress Syndrome After Cardiac Surgery :a Single Centre Random Control Trial.
Status: NOT_YET_RECRUITING
Conditions: Cardiac Disease
Interventions: DRUG: Sivelestat|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: RewinD-LB - Clinical Study of Neflamapimod in Patients With Dementia With Lewy Bodies
Status: ACTIVE_NOT_RECRUITING
Conditions: Dementia With Lewy Bodies
Interventions: DRUG: Neflamapimod|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Providing Resources to Enhance Patients' Readiness to Make Decisions About Kidney Disease: The PREPARE NOW Study
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: BEHAVIORAL: PREPARED Decision Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: n-3 Polyunsaturated Fatty Acids (PUFA) Supplementation in Young Women With Polycystic Ovary Syndrome (PCOS)
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DIETARY_SUPPLEMENT: LC n-3 PUFA (fish oil) Supplement|DIETARY_SUPPLEMENT: Placebo (olive oil) supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lidoderm Patch (Lidocaine 5%) for Tinnitus Treatment
Status: UNKNOWN
Conditions: Tinnitus
Interventions: DEVICE: Lidoderm patch (Lidocaine 5% patch)|OTHER: Tegaderm patch. (neutral patch, containing no drug)|PROCEDURE: blood test- serum lidocain levels|OTHER: Hearing tests
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Joint Position Sense, Plantar Sensation, Balance and Dual Task Performance in Individuals With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Balance
Interventions: OTHER: Ankle Joint Position Sensation Evaluation|OTHER: Knee Joint Position Sensation Evaluation|OTHER: The Evaluation of Plantar Sensation|OTHER: The Evaluation of Balance|OTHER: Evaluation of Dual Task Performance|OTHER: General Evaluation Form
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Canadian Oxygen Trial (COT)
Status: COMPLETED
Conditions: Respiratory Insufficiency of Prematurity
Interventions: OTHER: Titration of oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Periodontal Therapy on Patients With Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type II|Periodontitis
Interventions: DRUG: Chlorhexidine gluconate oral rinse|PROCEDURE: Scaling & Root Planing|DEVICE: Soft Picks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CCA of SGB PCR Versus SGB Culture at 35-38 SA in the Optimization of Intrapartum Antibiotic Prophylaxis
Status: COMPLETED
Conditions: Streptococcus Agalactiae
Interventions: DIAGNOSTIC_TEST: SGB PCR|DIAGNOSTIC_TEST: SGB culture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Sequential Use of Fluoxetine for Smokers With Elevated Depressive Symptoms
Status: COMPLETED
Conditions: Major Depressive Disorder|Nicotine Dependence|Depression
Interventions: DRUG: Fluoxetine|DRUG: Dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Flourish HEC Vaginal Care System on Birth-Related Pelvic Floor Disorders
Status: TERMINATED
Conditions: Pelvic Floor Disorders
Interventions: DEVICE: Flourish HEC, which contains BioNourish|OTHER: Routine pelvic physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Three Different Oral Moisturizers in Palliative Care Patients.
Status: UNKNOWN
Conditions: Xerostomia
Interventions: DEVICE: Glycerol 17%|DEVICE: Aequasyal (OGT)|DEVICE: Salient (new product)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oral Vitamin B12 as Potential Treatment of Recurrent Aphthous Stomatitis
Status: COMPLETED
Conditions: Recurrent Aphthous Stomatitis
Interventions: DRUG: daily sublingual tablets Vitamin B12 1000 mcg versus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Autologous ADRC Treatment of Autoimmune Refractory Epilepsy
Status: COMPLETED
Conditions: Refractory Epilepsy
Interventions: BIOLOGICAL: ADRC transplantation in autoimmune refractory epilepsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SuperDEX Trial (Comparison of Two Doses of Dexamethasone for Malignant Spinal Cord Compression Treated by Radiotherapy).
Status: COMPLETED
Conditions: Spinal Cord Compression From Neoplasm Metastasis
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Nivolumab Plus Brentuximab Vedotin in Patients Between 5 and 30 Years Old, With Hodgkin's Lymphoma (cHL), Relapsed or Refractory From First Line Treatment
Status: COMPLETED
Conditions: Hodgkin Disease
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: brentuximab vedotin|BIOLOGICAL: bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 5-Fluorouracil Combined With CoFactor (5-10 Methylenetetrahydrofolate) in Treating Advanced Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: CoFactor (ANX-510)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALT-803 Plus Nivolumab in Patients With Pretreated, Advanced or Metastatic Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: ALT-803|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Highly Challenging Balance Program to Reduce Fall Rate in PD
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: BEHAVIORAL: Facility-based structured exercise|BEHAVIORAL: Home-based structured exercise|BEHAVIORAL: Health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Efficacy Between ILM Forceps
Status: NOT_YET_RECRUITING
Conditions: Macular Holes|Epiretinal Membrane
Interventions: DEVICE: Internal limiting membrane (ILM) Peeling with Sharkskin Forceps|DEVICE: Internal limiting membrane (ILM) Peeling with Standard Forceps
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Screening With FibroTouch for Advanced Liver Fibrosis in NAFLD Patients With Underlying Type 2 Diabetes
Status: RECRUITING
Conditions: Type 2 Diabetes Mellitus|Nonalcoholic Fatty Liver Disease (NAFLD)
Interventions: DIAGNOSTIC_TEST: FibroTouch
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Firategrast (SB683699) Surface Area Study in Multiple Sclerosis Patients
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Formulation A|DRUG: Formulation B|DRUG: Formulation C|DRUG: Formulation D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Rituximab After ASCT in High-Risk Diffuse Large B-Cell Lymphoma
Status: TERMINATED
Conditions: CD20-Positive Large B-Cell Lymphoma
Interventions: DRUG: ACVBP|DRUG: ACE|DRUG: rituximab|PROCEDURE: Autologous stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Topical Coenzyme Q10 in Management of Oral Aphthous Ulcer
Status: UNKNOWN
Conditions: Oral Aphthous Ulcer
Interventions: DRUG: topical coenzyme Q10 gel|DRUG: Carpabol gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pulsed Dye Laser in Treating Superficial Basal Cell Carcinomas
Status: COMPLETED
Conditions: Basal Cell Carcinoma
Interventions: PROCEDURE: Laser treatment|DEVICE: SHAM-Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety/Efficacy Study of Oxycodone HCl/Niacin to Treat Pain After Bunionectomy
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Placebo|DRUG: Acurox 5/30 mg|DRUG: Acurox 7.5/30
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of REGN1400 Alone and in Combination With Erlotinib or Cetuximab in Patients With Certain Types of Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: REGN1400|DRUG: Erlotinib|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation of Pre-emptive Geno- and Phenotyping in 5-Fluorouracil- or Capecitabine-treated Patients
Status: UNKNOWN
Conditions: Colon Cancer|Stomach Tumor|Anal Tumor|Pancreas Cancer|Esophageal Cancer
Interventions: DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Intermittent Fasting and Mediterranean Diet on the Physical Health of the Elderly
Status: COMPLETED
Conditions: Diabetes|Hypertension|Dyslipidemias|Obesity
Interventions: OTHER: Time Restricted Feeding|OTHER: Mediterranean Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: All-trans Retinoic Acid (ATRA) in the Treatment of Recurrent/Metastatic Adenoid Cystic Carcinoma of the Head and Neck
Status: UNKNOWN
Conditions: Adenoid Cystic Carcinoma of the Head and Neck
Interventions: DRUG: All-trans Retinoic Acid|DRUG: VEGFR inhibitor|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Compressive Therapies on the Healing of Venous Ulcers
Status: COMPLETED
Conditions: Venous Ulcers
Interventions: PROCEDURE: Dressing with monolayer high compression elastic bandage|PROCEDURE: Dressing with Unna boot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Triceps Surae Trigger Point Size and Muscle Extensibility
Status: COMPLETED
Conditions: Limited Dorsiflexion|Limited Ankle Range of Motion
Interventions: PROCEDURE: Dry Needling|PROCEDURE: Stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of LY2606368 Therapy in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescents With Refractory or Recurrent Group 3/Group 4 or SHH Medulloblastoma Brain Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Brain Tumor|Brain Tumor, Recurrent|Brain Tumor, Refractory|Brain Tumor, Pediatric|Medulloblastoma|Medulloblastoma Recurrent|Medulloblastoma, Non-WNT/Non-SHH|Medulloblastoma, Non-WNT/Non-SHH, Group 3|Medulloblastoma, Non-WNT/Non-SHH, Group 4|Brain Cancer|CNS Cancer|CNS Tumor|CNS Neoplasm
Interventions: DRUG: Prexasertib|DRUG: Cyclophosphamide|DRUG: Gemcitabine|BIOLOGICAL: filgrastim|BIOLOGICAL: peg-filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of EUS-Guided Therapy Versus BRTO for Gastric Varices With Shunt
Status: COMPLETED
Conditions: Portal Hypertension|Liver Cirrhosis|Gastric Varix|Portosystemic Shunt
Interventions: PROCEDURE: EUS-guided coil embolization combined with endoscopic cyanoacrylate injection|PROCEDURE: balloon-occluded retrograde transvenous obliteration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Added Value of SVC Isolation in Patients With Pulmonary Vein Reconnection Undergoing Repeat Ablation for Recurrent Paroxysmal AF
Status: UNKNOWN
Conditions: Paroxysmal Atrial Fibrillation
Interventions: PROCEDURE: PVI|PROCEDURE: PVI + SVC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Impact of Corneal Width on Surgically Induced Astigmatism (SIA) and Functional Results After Bimanual 1.4 mm Microincision Cataract Surgery (B-MICS), Coaxial 1.8 mm MICS (C-MICS) and 2.4 mm Small Incision Cataract Surgery (C-SICS).
Status: COMPLETED
Conditions: Cataract|Corneal Astigmatism|Corneal Incision Contracture
Interventions: PROCEDURE: Bimanual 1.4 mm microincision cataract surgery (B-MICS) with IOL implantation in a "wound-assisted" technique. In bimanual MICS group a self-sealing 1.4 mm wide incision was created supratemporally|PROCEDURE: Coaxial 1.8 mm microincision cataract surgery (C-MICS) with IOL implantation with an injector through the 1.8 mm wide incision created temporally.|PROCEDURE: Coaxial 2.4 mm small incision cataract surgery (C-SICS) with IOL implantation with an injector through the 2.4 mm wide incision located temporally.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Ruxolitinib in Patients With Grade II to IV Steroid-refractory Acute Graft vs. Host Disease
Status: RECRUITING
Conditions: Steroid-refractory Acute Graft Versus Host Disease
Interventions: DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive and Affective Mechanisms Underlying an Olfactory Approach to Modify Cigarette Craving
Status: RECRUITING
Conditions: Craving
Interventions: BEHAVIORAL: Pleasant Odor|BEHAVIORAL: Odor Blank
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pembrolizumab + Paclitaxel in Hormone Receptor-positive (HR+)/Human Epidermal Growth Factor Receptor 2-negative (HER2-) Non-luminal (by PAM50) Advanced Breast Cancer After Cyclin-dependent Kinase 4/6 (CDK4/6) Inhibitors Progression
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial of Recombinant Humanized Anti-IL-2 Receptor Antibody (Daclizumab) Versus Antithymocyte Globulin (ATG) to Treat the Cytopenia of Myelodysplastic Syndrome (MDS)
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Daclizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Laser Closure of Anal Fistula (FiLaC)
Status: UNKNOWN
Conditions: Anal Fistula|Fistula in Ano|Sphincter Ani Incontinence
Interventions: PROCEDURE: Laser closure of the anal fistula tract (FiLaC)|PROCEDURE: Internal orifice closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-component Cognitive Intervention for Older Adults With Mixed Cognitive Abilities
Status: COMPLETED
Conditions: Cognitive Training|Dementia|Occupational Therapy|Aging|Long Term Care
Interventions: BEHAVIORAL: Multi-component cognitive intervention with simulated everyday tasks (MCI-SET)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase IIa Trial of ALXN1007 for the Treatment of Non-criteria Manifestations of Antiphospholipid Syndrome
Status: TERMINATED
Conditions: Antiphospholipid (aPL)-Positive
Interventions: BIOLOGICAL: Study Drug- ALXN1007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Versus Dexamethasone With Levobupivacaine in Interscalene Block
Status: COMPLETED
Conditions: Postoperative Analgesia|Postoperative Complications
Interventions: DRUG: Saline|DRUG: Dexamethasone Injection|DRUG: Dexmedetomidine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effects of a New Treatment in Patients With Chronic Pain
Status: COMPLETED
Conditions: Peripheral Neuropathies
Interventions: BEHAVIORAL: Heat pain stimuli A|BEHAVIORAL: Video A|DRUG: Administration of T4P1001 capsules|BEHAVIORAL: Heat pain stimuli B|BEHAVIORAL: Video B|DRUG: Administration of placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Tolerance of a Follow-On Formula Fed to Children From 12-48 Months of Age in Salvador, Bahia, Brazil
Status: COMPLETED
Conditions: Acute Respiratory Infection|Diarrheal Disease
Interventions: DIETARY_SUPPLEMENT: Cow's milk|DIETARY_SUPPLEMENT: Follow-On Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Multicenter Implementation Study of the 3 Wishes Project
Status: COMPLETED
Conditions: Death|Communication, Multidisciplinary|Empathy|Compassion|Family Members|Bereavement|Empowerment|Patient Engagement
Interventions: BEHAVIORAL: Focused end-of-life conversations to promote connections among patients, family members and clinicians.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exploring the Profiles of RMS Patients on Ofatumumab or Ocrelizumab in a Real-World Setting in the Gulf
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsing Multiple Sclerosis
Interventions: OTHER: Ofatumumab|OTHER: Ocrelizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate Safety and Efficacy of Dutogliptin in Type 2 Diabetes Mellitus Subjects With Moderate and Severe Renal Impairment
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus|Renal Impairment
Interventions: DRUG: dutogliptin|DRUG: dutogliptin|DRUG: placebo|DRUG: sitagliptin|DRUG: sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety on Heart Rate Control With Ivabradine on Cardiogenic Shock
Status: UNKNOWN
Conditions: Cardiogenic Shock
Interventions: DRUG: Ivabradine Oral Tablet|OTHER: Standard of Care treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Positioning on Back Pain After TACE Among Patients With HCC
Status: COMPLETED
Conditions: Liver Cancer|Transcatheter Arterial Chemoembolization
Interventions: OTHER: Changing body position in bed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Validity of Computed Tomography Versus Magnetic Resonance Imaging in Predicting Muscular Invasion of Bladder Cancer
Status: RECRUITING
Conditions: Bladder Cancer
Interventions: DIAGNOSTIC_TEST: CT with contrast|DIAGNOSTIC_TEST: MRI pelvis|PROCEDURE: TURBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Single-dose and Steady-state TPV/r on the Steady-state Pharmacokinetics of Clarithromycin and a Preliminary Assessment of the Effects of a Standard High-fat Test Meal on the Steady-state Pharmacokinetics of Tipranavir
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tipranavir|DRUG: Ritonavir|DRUG: Clarithromycin|OTHER: High-Fat Test Meal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT