pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Bioavailabity of the Major Metabolites of a Botanical Extract, in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: SBE|DIETARY_SUPPLEMENT: DBE|DIETARY_SUPPLEMENT: BP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemotherapy With Pyrotinib, Epirubicin and Cyclophosphamide Followed by Taxanes and Trastuzumab for HER-2+ Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Pyrotinib|DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: Taxanes|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Screening Tools to Predict Treatment Outcome in Older Cancer Patients Who Are Undergoing Treatment
Status: UNKNOWN
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: OTHER: questionnaire administration|PROCEDURE: cognitive assessment|PROCEDURE: examination|PROCEDURE: management of therapy complications
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intermittent Hypoxia to Enhance Motor Function After Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Hypoxia via Hypoxico Hyp-123|DEVICE: Sham via Hypoxico Hyp-123
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fluorescent Evaluation of Colorectal Anastamoses
Status: COMPLETED
Conditions: Rectal Neoplasms|Colon Neoplasms|Diverticulitis
Interventions: DEVICE: Indocyanine Green|DEVICE: The SPY® Intraoperative Imaging System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Optimizing Weight Loss Outcomes Through Body Image Enhancement
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: BEHAVIORAL: Experimental: Lifestyle Intervention with Body Image Treatment (LIBI)|BEHAVIORAL: Lifestyle Intervention (LI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of NBI-98854 in Pediatric Subjects With Tourette Syndrome
Status: TERMINATED
Conditions: Tourette Syndrome
Interventions: DRUG: Valbenazine|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Bemnifosbuvir in Subjects With Normal and Impaired Hepatic Function
Status: COMPLETED
Conditions: Healthy Volunteer|Hepatic Impairment
Interventions: DRUG: Bemnifosbuvir (BEM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trans-coronary Cooling and Dilution for Cardioprotection During Revascularisation for ST-elevation Myocardial Infarction
Status: RECRUITING
Conditions: Myocardial Infarction|Reperfusion Injury, Myocardial
Interventions: OTHER: Transcoronary cooling and dilution|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IncobotulinumtoxinA (Xeomin) to Treat Focal Hand Dystonia
Status: RECRUITING
Conditions: Focal Hand Dystonia
Interventions: DRUG: Xeomin|DRUG: Placebo - Concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Two Exercise Programs on Knee Motor Control
Status: COMPLETED
Conditions: Knee Pain|Patellofemoral Pain
Interventions: BEHAVIORAL: Motor control retraining program|BEHAVIORAL: Quadriceps strengthening program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Mindfulness Meditation App on Subjective Well-Being in Undergraduate University Students
Status: COMPLETED
Conditions: Stress, Psychological
Interventions: BEHAVIORAL: Mindfulness Training App|BEHAVIORAL: Cognitive Training With 2048
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Inhalation of Lidocaine Before Intubation
Status: UNKNOWN
Conditions: Sore Throat
Interventions: DRUG: Lidocaine inhalation|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase Ib Trial of LEE011 With Everolimus (RAD001) and Exemestane in the Treatment of Hormone Receptor Positive HER2 Negative Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: ribociclib (LEE011)|DRUG: Exemestane|DRUG: Everolimus (RAD001)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy on Cardiac Remodeling of Recombinant Human Neuregulin-1 in Stable Chronic Systolic Heart Failure Patients
Status: TERMINATED
Conditions: Chronic Systolic Heart Failure
Interventions: DRUG: rhNRG-1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin to Improve Cosmesis of Primary Cleft Lip Repair
Status: COMPLETED
Conditions: Cleft Lip|Scarring|Cleft Palate
Interventions: DRUG: Botulinum Toxin Type A|DRUG: Normal Saline Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Visceral and Parietal Peritoneum Suturation on Postoperative Vital Signs
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: PROCEDURE: Group 1: Only visceral peritoneum will be closed|PROCEDURE: Group 2 : Only parietal peritoneum will be closed|PROCEDURE: Group 3 : Both of them will be closed|PROCEDURE: Group 4: None of them will be closed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: "Twelve-week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in Narcolepsy"
Status: COMPLETED
Conditions: Narcolepsy
Interventions: DRUG: JZP-110|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Side-effects of Autologous Skin Tissue Harvesting
Status: COMPLETED
Conditions: Scar
Interventions: DEVICE: Micro biopsy|PROCEDURE: Lidocaine with epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Music for Anxiety in Embryo Transfers
Status: NOT_YET_RECRUITING
Conditions: REPRODUCTIVE TECHNIQUES|Embryo Transfer|Music|Test Anxiety|Patient Satisfaction
Interventions: OTHER: Music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Drug-drug Interaction Study of DP-R213
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cholecalciferol|DRUG: Raloxifene|DRUG: Cholecalciferol and Raloxifene co-administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluate the Efficacy of RespireAidTM in Patient With Externally Contracted Seasonal Epidemic (外感時疫)
Status: COMPLETED
Conditions: Respiration Disorders
Interventions: DIETARY_SUPPLEMENT: RespireAid TM/placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Aerobic and Resistant Exercise Training in Patients With Non-Alcoholic Steatohepatitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Alcoholic Steatohepatitis
Interventions: OTHER: resistance and aerobic exercise|OTHER: physical activity recommendation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Apatinib as the First-Line Therapy in Elderly Locally Advanced or Metastatic Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer|Apatinib|Biomarker
Interventions: DRUG: Apatinib mesylate tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Association of Acupuncture and Cupping in Advanced Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis|Pain, Chronic
Interventions: PROCEDURE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Feasibility Study to Evaluate the Safety and Efficacy of PAK HD in ESRD Patients
Status: COMPLETED
Conditions: End Stage Renal Disease|ESRD
Interventions: DEVICE: PAK HD Sorbent Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study to Compare Quality of Life and Satisfaction in Primary Immunodeficient Patients Treated With Subcutaneous Injections of Gammanorm® 165 mg/mL Administered With Two Different Delivery Devices: Injections Using Pump or Rapid Push
Status: COMPLETED
Conditions: Primary Immunodeficiency
Interventions: DEVICE: Chrono Super PID then Generic Syringe-Gammanorm|DEVICE: Generic Syringe then Chrono Super PID-Gammanorm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Low-dose 500 mg Abiraterone Acetate in Treatment of Metastatic Prostate Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer|Metastatic Cancer|Hormone Sensitive Prostate Cancer|Castration-resistant Prostate Cancer
Interventions: DRUG: Abiraterone Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EU/LA Pearl Index Study - Transdermal Contraceptive Patch
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Ethinylestradiol/Gestodene (BAY86-5016)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Preoperative Lenvatinib Plus Pembrolizumab in Early-Stage Triple-Negative Breast Cancer (TNBC)
Status: RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Lenvatinib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alcohol-free Essential Oils Containing Mouthrinse Efficacy on 3-day Supragingival Plaque Regrowth
Status: COMPLETED
Conditions: Gingivitis|Periodontitis
Interventions: OTHER: alcohol free essential oils mouthwash|OTHER: alcohol essential oils mouthwash|OTHER: 0.20% chlorhexidine mouthwash|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Pegfilgrastim Administered on the Same Day as Chemotherapy in Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: pegfilgrastim|DRUG: pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clofarabine and Temsirolimus in Treating Older Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: clofarabine|DRUG: temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Study of Tipepidine Hibenzate in Patients With Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: Tipepidine Hibenzate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Confocal Fluorescence Microscopy of the Human Airways in Diagnostics of Lung Transplantation
Status: WITHDRAWN
Conditions: Disorder Related to Lung Transplantation
Interventions: DEVICE: Alveoflex Confocal MiniprobeTM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Afatinib (GILOTRIF®) in Patients Suffering From Tumors Harboring Neuregulin 1 (NRG1) Gene Alterations (Specifically NRG1 Gene Fusion-positive Advanced Solid Tumors)
Status: NO_LONGER_AVAILABLE
Conditions: Solid Tumors
Interventions: DRUG: afatinib
Study Type: EXPANDED_ACCESS
Clinical trial: A Study of Zolpidem Tartrate Sublingual Tablet in Adult Patients With Insomnia
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: zolpidem tartrate sublingual tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Trial to Assess the Safety and Immunogenicity of an Inactivated, Adjuvanted Whole Zika Virus Vaccine Candidate (VLA1601) in Healthy Adults
Status: RECRUITING
Conditions: Zika|Zika Virus Infection
Interventions: BIOLOGICAL: VLA1601|BIOLOGICAL: CpG 1018®|BIOLOGICAL: 3M-052-AF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of SBI, a Medical Food, on Nutritional Status in Patients With HIV-associated Enteropathy
Status: COMPLETED
Conditions: HIV-associated Enteropathy
Interventions: OTHER: Serum-derived bovine immunoglobulin protein isolate (SBI)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Examination of Efficacy and Safety of Other Anti-Resorption Drugs After 2-year-Denosumab Therapy in Japanese Osteoporosis Patients
Status: RECRUITING
Conditions: Osteoporosis
Interventions: DRUG: SERM "Viviant®Tablet 20mg" and ELD "Edirol®Tablet 0.75ug"|DRUG: Bisphosphonates and ELD "Edirol®Tablet 0.75ug"|DRUG: ELD "Edirol®Tablet 0.75ug"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Versus Open Pancreatectomy
Status: WITHDRAWN
Conditions: Pancreatectomy
Interventions: PROCEDURE: Laparoscopic distal pancreatectomy|PROCEDURE: Open distal pancreatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extension Study of Linifanib (ABT-869) in Subjects With Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: linifanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of ACT and Float REST on Burnout Syndrome.
Status: TERMINATED
Conditions: Burnout Syndrome
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy (ACT)|BEHAVIORAL: Float REST|BEHAVIORAL: ACT + Float REST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study Assessing Complete Wound Healing by Comparing Surgenex® PelloGraft in Treating DFU and SanoGraft® in Treating VLU to SOC
Status: RECRUITING
Conditions: Diabetic Foot Ulcer|Venous Leg Ulcer
Interventions: OTHER: SanoGraft|OTHER: PelloGraft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Absorption Rate From Different Oral Fe-supplements in Obese Volunteers Pre- and Post-RYGB
Status: UNKNOWN
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Iron supplements, more specific Ferrodyn and Vista Ferrum
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dopamine Effect on Inhibitory Control
Status: COMPLETED
Conditions: Idiopathic Parkinson's Disease
Interventions: DRUG: PD patients H&Y=1.5-2 Medications ON|DRUG: PD patients H&Y=1.5-2 Medications OFF|BEHAVIORAL: Healthy age-matched controls|DRUG: PD patients H&Y=3 Medications OFF|DRUG: PD patients H&Y=3 Medications ON
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Low Dose Dexmedetomidine as a Postoperative Pain Adjunct
Status: ENROLLING_BY_INVITATION
Conditions: Spinal Fusion|Adolescent Idiopathic Scoliosis
Interventions: DRUG: Dexmedetomidine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Bathing With Chlorhexidine Impregnated Cloths on Nosocomial Infections in the Pediatric Intensive Care Unit
Status: COMPLETED
Conditions: Nosocomial Infections
Interventions: DRUG: 2% Chlorhexidine gluconate cloth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Biomarkers in Predicting Treatment Response to Sirolimus and Chemotherapy in Patients With High-Risk Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Recurrent Adult Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: Sirolimus|DRUG: Mitoxantrone|DRUG: Etoposide|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Angioplasty + SBCV vs. Angioplasty Alone for Femoropopliteal Artery Stenosis
Status: UNKNOWN
Conditions: Peripheral Arterial Disease
Interventions: OTHER: SBCV|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of a Three-Day Fosaprepitant Regimen for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Pediatric Participants (MK-0517-045)
Status: COMPLETED
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: DRUG: Fosaprepitant Dimeglumine|DRUG: 5-HT3 antagonist|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Very Low Tidal Volume vs Conventional Ventilatory Strategy for One-lung Ventilation in Thoracic Anesthesia
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome
Interventions: PROCEDURE: Protective one lung ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Cardiovascular Longitudinal ALSPAC Research Investigations Following Hypertensive Pregnancy in Young Adulthood
Status: RECRUITING
Conditions: Young Adult|Hypertension in Pregnancy|Hypertension|Cardiovascular Diseases|Cerebrovascular Diseases|Vascular Diseases
Interventions: OTHER: History of being born to hypertensive or normal pregnancy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Post Extraction Alterations Following Ridge Preservation In The Esthetic Zone Using Partially Demineralized Autogenous Dentine Graft Versus Xenograft
Status: RECRUITING
Conditions: Socket Preservation
Interventions: BIOLOGICAL: autogenous partially demineralized dentin graft|BIOLOGICAL: Xenograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Study to Evaluate the Efficacy of the Home Based Electrical Transcutaneous URIS I in the Treatment of Overactive Bladder (OAB).
Status: COMPLETED
Conditions: Overactive Bladder (OAB)|Failed Any OAB Pharmacotherapy
Interventions: DEVICE: eTNM delivered by URIS I nerve stimulation device
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transdiagnostic iCBT for Depression and Anxiety
Status: COMPLETED
Conditions: Major Depressive Disorder|Social Anxiety Disorder|Panic Disorder|Generalized Anxiety Disorder
Interventions: BEHAVIORAL: iCBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Inhalation vs Total Intravenous Anesthesia on the Immune Status and Mortality in Patients Undergoing Breast Cancer Surgery: a Prospective Double-Blind Randomized Clinical Trial.
Status: RECRUITING
Conditions: Anesthesia|Breast Cancer
Interventions: DRUG: Sevoflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: baSal BoluS Therapy in patIenTs With TypE 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: INSULIN GLARGINE|DRUG: INSULIN GLULISINE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Proposed Cav1.3 Inhibitor in Primary Aldosteronism
Status: COMPLETED
Conditions: Primary Aldosteronism|Endocrine Hypertension
Interventions: DRUG: Cinnarizine|DRUG: NIFEdipine ER
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study To Evaluate The Effect Of Single Intravenous Doses Of Tigecycline On QTc Intervals In Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: tigecycline|DRUG: tigecycline|DRUG: moxifloxacin|DRUG: 100 mL 0.9% Sodium Chloride intravenous|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Meloxicam SoluMatrix® Capsules vs Meloxicam Tablets to Treat Osteoarthritis Pain
Status: WITHDRAWN
Conditions: Osteoarthritis
Interventions: DRUG: Meloxicam Test Capsules|DRUG: Meloxicam Test Capsules|DRUG: Meloxicam Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of SNF and SBCC to Prevent Stunting Among Children in Afghanistan: a Quasi-experimental Study
Status: COMPLETED
Conditions: Stunting|Malnutrition, Child
Interventions: DIETARY_SUPPLEMENT: Super Cereal - wheat soya blend with sugar|DIETARY_SUPPLEMENT: Lipid-based nutrient supplement-medium quantity (LNS-MQ)|BEHAVIORAL: Social and behavior change communication (SBCC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prevalence of HIV +ve Cases With AIDS Defining Opportunistic Infections Among ART Naive Patients Attending ART Centre
Status: COMPLETED
Conditions: HIV Infections|Tuberculosis|Candidiasis, Esophageal|Cryptococcosis|Leishmaniasis|Toxoplasmosis
Interventions: OTHER: CD4 cell count
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase I/IIa Trial to Evaluate AVX001 Gel in Doses of 1% or 3% Compared With Vehicle Over Four Weeks of Field-directed Treatment Period in Adult Subjects With AK
Status: UNKNOWN
Conditions: Actinic Keratoses
Interventions: DRUG: AVX001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of IV NSAID's and Corticosteroids on Dysphasia and Dysphonia Following ASDF
Status: TERMINATED
Conditions: Dysphagia|Dysphonia
Interventions: DRUG: Intravenous Ketorolac|DRUG: Intravenous Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Food Insulin Index on Metabolic Parameters in Obese Adolescents
Status: COMPLETED
Conditions: Pediatric Obesity
Interventions: OTHER: LGI-LII Breakfast|OTHER: LGI-HII Breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Postural Alignment Exercise Mobile App for Cervical and Thoracic Spine Regions
Status: COMPLETED
Conditions: Development and Design of Mobile App|Preventive Physiotherapy|Exercise Adherence|Cervical and Thoracic Spine
Interventions: OTHER: App-based group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adapting Anxiety Intervention for Youth With Autism for Rapid Response to COVID-19
Status: UNKNOWN
Conditions: Autism Spectrum Disorder
Interventions: OTHER: Cognitive behavior therapy (CBT), specifically using the Facing Your Fears (FYF) curriculum
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy Combined With Immunochemotherapy in Metastatic Esophageal Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma|Esophageal Cancer|Metastatic Esophageal Squamous Cell Carcinoma
Interventions: RADIATION: LDRT+CFRT|DRUG: Immunotherapy|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rural Andhra Pradesh Cardiovascular Prevention Study (RAPCAPS)
Status: COMPLETED
Conditions: Myocardial Infarction|Angina Pectoris|Cerebrovascular Accidents|Diabetes Mellitus
Interventions: DRUG: ASA, Atenolol, hydrochlorothiazide, ACE inhibitor, Statin|BEHAVIORAL: Health Promotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effects of FODMAPs in Patients With Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: OTHER: Diet moderate/high in FODMAPs|OTHER: Diet low in FODMAPs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of a Portable Oxygen Concentrator During Ambulation for Patients Who Require Supplemental Oxygen (POC-LEAN)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Portable Oxygen Cylinder|DEVICE: Mobi
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Risk-adapted Therapy for Adult Acute Myeloid Leukemia.
Status: COMPLETED
Conditions: Leukemia, Myelocytic, Acute
Interventions: DRUG: Ara-C|OTHER: Autologous transplantation|OTHER: Allogeneic HLA-identical sibling transplantation|OTHER: CD34+ selection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peripheral-central Correlation Study on the Treatment of Chronic Tinnitus With "Dao qi Tong Luo" Based on the Theory of "Connecting the Two Ears to the Brain"
Status: RECRUITING
Conditions: Tinnitus
Interventions: PROCEDURE: The "dao qi tong luo" group|PROCEDURE: The acupuncture group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Avmacol® in the Oral Mucosa of Patients Following Curative Treatment for Tobacco-related Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer|Head and Neck Squamous Cell Carcinoma (HNSCC)|Head and Neck Carcinoma|Head and Neck|Tobacco-Related Carcinoma|Carcinoma in Situ|Dysplasia|Hyperplasia|Premalignant Lesion
Interventions: DIETARY_SUPPLEMENT: Avmacol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mitomicin C for Prevention Postoperative Endoscopic Sinus Surgery Synechia and QOL in Chronic Rhinosinusitis
Status: COMPLETED
Conditions: Chronic Rhinosinusitis|Postoperative Nasal Synerchia
Interventions: DRUG: Mitomicin C|DRUG: Identical placebo solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Epstein-Barr Virus-Specific Immunotherapy for Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma
Interventions: BIOLOGICAL: Epstein-Barr Virus Specific Immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High and Low Dose Oral Peanut Immunotherapy - Comparison of Efficacy and Safety
Status: RECRUITING
Conditions: Peanut Allergy
Interventions: DIETARY_SUPPLEMENT: High dose of peanuts|DIETARY_SUPPLEMENT: Low dose of peanuts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acceptability and Feasibility of an ACT-Based Group to Improve Diabetes Self-Management
Status: WITHDRAWN
Conditions: Type 1 Diabetes Mellitus
Interventions: BEHAVIORAL: Diabetes self-management group based on Acceptance and Commitment Therapy (ACT).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Intranasal Oxytocin and Stress on Belief Updating
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cardiovascular Risk Factors in an Ambulatory Urban Patient Population
Status: COMPLETED
Conditions: Cardiovascular Risk Factors|Metabolic Syndrome|Lifestyle Modification|Coronary Artery Disease|Stroke
Interventions: BEHAVIORAL: Dietary and nutritional modification|BEHAVIORAL: Stop smoking|BEHAVIORAL: Regular physical activities|BEHAVIORAL: Weight reduction to normal ranges|BEHAVIORAL: Regular intake of polyphenols, esp. from Ilex paraguayensis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Pharmacists' Intervention on Pain Management in Cancer Patients
Status: COMPLETED
Conditions: Cancer|Cancer Pain
Interventions: OTHER: Clinical Pharmacist Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Laser Acupuncture Stimuli at ZUSANLI(ST36) on Pulse Spectrum Variations
Status: COMPLETED
Conditions: Harmonic Wave
Interventions: DEVICE: RJ-LASER, LASERPEN®; Reimers & Janssen, Germany
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison Of 5 CP-690,550 Doses Vs. Placebo, For The Treatment Of Rheumatoid Arthritis In Japan
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Placebo|DRUG: CP-690,550|DRUG: CP-690,550|DRUG: CP-690,550|DRUG: CP-690,550|DRUG: CP-690,550
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Persona Partial Knee Clinical Outcomes Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis|Avascular Necrosis|Traumatic Arthritis|Conditional Tibial Condyle or Plateau Fractures|Conditional Revision of the Articular Surface
Interventions: DEVICE: Persona Partial Knee system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NT-I7 in Combination With Nivolumab in Advanced Gastric, Gastro-Esophageal Junction or Esophageal Adenocarcinoma
Status: TERMINATED
Conditions: Gastric or Gastro-esophageal Junction (GEJ) or Esophageal Adenocarcinoma (EAC)
Interventions: DRUG: NT-I7|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of Two Oral Formulations of Topotecan in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Lung Cancer, Small Cell|Solid Tumor Cancer
Interventions: DRUG: topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Mineral Trioxide Aggregate (MTA) & Ferric Sulfate (FS) Pulpotomies
Status: TERMINATED
Conditions: Primary Teeth|Pulpotomy
Interventions: DEVICE: MTA|DRUG: Ferric Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of AI Monitoring Blind Spots of EGD on the Inspection Time and Lesion Dection Rate
Status: NOT_YET_RECRUITING
Conditions: Upper Gastrointestinal Symptoms
Interventions: DEVICE: Endoangle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Early Versus Delayed Bathing of Orthopaedic Surgical Wounds
Status: RECRUITING
Conditions: Surgical Wound|Post Operative Wound Infection
Interventions: OTHER: Time to bathing (delayed)|OTHER: Time to bathing (early)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Trial to Evaluate the the ReliantHeart HeartAssist 5® VAD System in Patients Awaiting Heart Transplantation
Status: TERMINATED
Conditions: Heart Failure|Cardiac Failure|Congestive Heart Failure|Heart Failure, Left-sided
Interventions: DEVICE: HeartAssist 5® VAD System|DEVICE: Control VAD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 12-week Study to Evaluate the Efficacy and Safety of Umeclidinium 62.5 Microgram (mcg) Compared With Glycopyrronium 44 mcg in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Umeclidinium|DRUG: Glycopyrronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of BIA 6-512 at Steady-state on the Levodopa Pharmacokinetics With a Single-dose of Levodopa/Benserazide 200/50 mg or With a Single-dose of Levodopa/Benserazide 200/50 mg Plus a Single-dose of Nebicapone 150 mg
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Placebo|DRUG: BIA 6-512|DRUG: Madopar® 250|DRUG: Nebicapone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Study to Evaluate the Immunogenicity and Safety of MG1109 in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: MG1109|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Presence of Humanoid Robot With Older Adults at Homes
Status: ACTIVE_NOT_RECRUITING
Conditions: Loneliness|Cognitive Impairment|Depression|Self Efficacy|Sense of Coherence
Interventions: BEHAVIORAL: A humanoid social robot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Study on Oncolytic Virus Injection (R130 OV) for the Treatment of Advanced Solid Tumors
Status: RECRUITING
Conditions: Sarcoma|Carcinoma|Digestive Cancer|Breast Cancer|Lung Cancer|Brain Cancer|Melanoma|Gynecologic Cancer|Head and Neck Cancer|Kidney Cancer
Interventions: DRUG: Recombinant oncolytic herpes simplex virus type 1 (R130)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Approach to Cervical Cancer
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: PROCEDURE: Total Abdominal Radical Hysterectomy|PROCEDURE: Total Laparoscopic or Robotic Radical Hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gallium-68 PSMA-11 PET in Intermediate to High-risk Preprostatectomy Patients
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Ga-68 labeled PSMA-11 PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I, Open-Label Study of the Safety, Tolerability, and Immunogenicity PEK Fusion Protein Vaccine
Status: UNKNOWN
Conditions: Cervical Intraepithelial Neoplasia
Interventions: BIOLOGICAL: PEK Fusion Protein Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-Guided Implant Radiation Therapy in Treating Patients With Locally Recurrent Prostate Cancer Previously Treated With External-Beam Radiation Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: RADIATION: 125-Iodine|RADIATION: 103-palladium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lobectomy and Mediastinal Radiochemotherapy in Unresectable Stage III Non-Small Cell Lung Cancer Responding to Induction Chemotherapy
Status: TERMINATED
Conditions: Non Small Cell Lung Carcinoma
Interventions: PROCEDURE: Lobectomy followed by concomitant mediastinal chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Haplo Peripheral Blood Sct In GVHD Prevention
Status: ACTIVE_NOT_RECRUITING
Conditions: GVHD|AML|ALL|MDS|MPN|CMML|Hodgkin Lymphoma|Non Hodgkin Lymphoma|Blood Stem Cell Transplant Failure|Graft Vs Host Disease|Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Myelodysplastic Syndromes|Myeloproliferative Disorder|Chronic Myelomonocytic Leukemia|Chemosensitive Hodgkin Lymphoma
Interventions: DRUG: FLUDARABINE|DRUG: CYCLOPHOSPHAMIDE|RADIATION: TBI|DRUG: Melphalan|DRUG: Sirolimus|DRUG: Mycophenolate mofetil|DRUG: RGI-2001|DRUG: CYCLOPHOSPHAMIDE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Corticosteroids in Oxygen-dependent Patients With COVID-19 Pneumonia
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: Prednisone|DRUG: Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cobicistat-containing Highly Active Antiretroviral Regimens in HIV-1 Infected Patients With Mild to Moderate Renal Impairment
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome|HIV Infections
Interventions: DRUG: E/C/F/TDF|DRUG: COBI|DRUG: ATV|DRUG: DRV|DRUG: NRTI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing Whether a Short Training Program Designed to Improve Cognitive Skills Improves 4-year-olds' Maths Skills
Status: COMPLETED
Conditions: Cognitive Development
Interventions: OTHER: Executive Function Intervention|OTHER: Active Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Expression of Programmed Death-1 (PD-1) & Programmed Death Ligand-1 (PDL-1) in Acute Lymphoblastic Leukemia in Pediatric
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia in Pediatric
Interventions: DIAGNOSTIC_TEST: flow cytometric immunophynotyping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pilot Study of AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric Intraocular Lens (IOL)
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Blind Study of Cranial Electrical Stimulation in Bipolar II Disorder
Status: COMPLETED
Conditions: Bi-polar II Disorder
Interventions: DEVICE: Active CES|DEVICE: Sham CES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors
Status: RECRUITING
Conditions: Oncology|MEK Mutation|RAF Gene Mutation|Ras (KRAS or NRAS) Gene Mutation|Melanoma|NSCLC|Glioma|Solid Tumor, Adult|MAPK Pathway Gene Mutation
Interventions: DRUG: NST-628
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AMBulatory UltraSound for Heart Failure Management
Status: RECRUITING
Conditions: Heart Failure
Interventions: PROCEDURE: An ultrasound (lung and inferior vena cava) will be performed and the heart failure treatments will be guided by the results of the lung ultrasound and the evaluation of the inferior vena cava.|PROCEDURE: Usual care without ultrasound guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The "VISION" Trial: Ventavis Inhalation With Sildenafil to Improve and Optimize Pulmonary Arterial Hypertension
Status: TERMINATED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Inhaled Iloprost (5 μg)|DRUG: Inhaled Placebo|DRUG: Sildenafil|DRUG: Bosentan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Follow-up Study to Evaluate the Safety of ALLO-ASC-DFU in ALLO-ASC-DFU-302 Clinical Trial
Status: RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: BIOLOGICAL: ALLO-ASC-DFU|PROCEDURE: Vehicle sheet
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase IV Study to Evaluate the Effect of Subcutaneous (SC) Tocilizumab Administered to Participants With Rheumatoid Arthritis (RA) Assessed Using Disease Activity Score (DAS28)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tocilizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Misoprostol Prior to Intrauterine Device (IUD) Insertion in Nulliparous Women
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Misoprostol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate Negative Pressure Incision Management System for Groin Wounds in Vascular Surgery Patients
Status: TERMINATED
Conditions: Surgical Procedure, Unspecified
Interventions: DEVICE: Prevena Incision Management System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessing the Clinical Efficacy of Hyaluronic Acid Hydrogel in Papilla Augmentation: A Clinical Study.
Status: RECRUITING
Conditions: Gingival Destruction
Interventions: OTHER: Hyaluronic acid gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension Study to Assess Safety and Efficacy of Pimecrolimus in Adult Patients With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Pimecrolimus Cream 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Levocetirizine and Hydroxyzine on Cognitive and Psychomotor Functioning During Simulated Diving
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Levocetirizine|DRUG: Hydroxyzine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Effect of Narrowband UVB Versus Methotrexate on Serum TWEAK Level in Psoriasis
Status: UNKNOWN
Conditions: Psoriasis
Interventions: RADIATION: Narrowband ultraviolet B|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT