pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of PF-06651600 Effect on Rosuvastatin Pharmacokinetics in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: PF-06651600|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: App-Based Mindfulness Intervention for the Improvement of Quality of Life in Patients With Metastatic Renal Cell Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Renal Cell Carcinoma|Stage IV Renal Cell Cancer AJCC v8
Interventions: BEHAVIORAL: Behavioral Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Radiofrequency Ablation in TIR3A Nodules With Negative Genetic Evaluation
Status: RECRUITING
Conditions: Thyroid Nodule
Interventions: PROCEDURE: Radiofrequency ablation performed with a 19 gauge STARmed needle.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Schroth Exercises on Pulmonary Function in Adolescent Idiopathic Scoliosis
Status: COMPLETED
Conditions: Adolescent Idiopathic Scoliosis|Pulmonary Function
Interventions: OTHER: Brace and Exercise Treatment|OTHER: Brace Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine/Nab-Paclitaxel With HIGRT in Resectable Pancreatic Cancer
Status: COMPLETED
Conditions: Resectable Pancreatic Cancers
Interventions: DRUG: Gemcitabine/nab-Paclitaxel|RADIATION: Radiation therapy|OTHER: Sugical resection|DRUG: Adjuvant chemotheapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Japanese BAY86-9766 Monotherapy Phase I Study
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: BAY86-9766|DRUG: BAY86-9766|DRUG: BAY86-9766|DRUG: BAY86-9766
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Imperial Comprehensive Cognitive Assessment in Cerebrovascular Disease (IC3)
Status: RECRUITING
Conditions: Stroke|Stroke (CVA) or TIA|Dementia, Vascular|Cerebrovascular Disorders|Small Vessel Cerebrovascular Disease|Cognitive Impairment
Interventions: DIAGNOSTIC_TEST: MRI brain, Blood tests, cognitive assessments
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the Effects of Negative Emotions on Endothelial Function
Status: COMPLETED
Conditions: Emotions|Endothelial Dysfunction
Interventions: OTHER: Anger Induction|OTHER: Depressed Mood Induction|OTHER: Anxiety Induction|OTHER: Neutral emotion task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder|Alcohol Withdrawal|Ketosis
Interventions: DIETARY_SUPPLEMENT: ketone supplement "D-beta-hydroxybutryric acid and R-1,3 butanediol" 12g of ketones,|DIAGNOSTIC_TEST: magnetic resonance imaging session|DIETARY_SUPPLEMENT: Placebo beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Honey Used as Adjunct Therapy to Tylenol for Post-Op Tonsillectomy Patients
Status: COMPLETED
Conditions: Tonsillectomy
Interventions: DIETARY_SUPPLEMENT: Honey|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of KeraStat Gel for Improved Cosmesis of Partial Thickness Burns
Status: TERMINATED
Conditions: Partial-thickness Burn
Interventions: DEVICE: KeraStat Gel|DEVICE: Silver Sulfadiazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Lubricity of Food Gels on Satiation and Satiety
Status: COMPLETED
Conditions: Appetitive Behavior
Interventions: DIETARY_SUPPLEMENT: Low lubricity (LL) hydrogels containing fibre-based beads
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interventional Strategies in Treatment of Atrial Fibrillation: Percutaneous Closure of the Left Atrial Appendage Versus Catheter Ablation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Percutaneous closure of LAA|PROCEDURE: Catheter ablation of AF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Outpatient Intravenous Diuretic Therapy for Treatment of Worsening Heart Failure (OUTPATIENT-WHF)
Status: RECRUITING
Conditions: Heart Failure
Interventions: OTHER: Initial outpatient management strategy, including outpatient IV diuretics in clinic|OTHER: Initial hospitalization-based management strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Work-focused Versus Generic Internet-based Interventions for Stress-related Disorders
Status: COMPLETED
Conditions: Adjustment Disorders
Interventions: BEHAVIORAL: Internet-based Cognitive-behavioural therapy|BEHAVIORAL: Work-focused Cognitive-behavioural therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Abduction External Rotation Brace and Arm Sling After Arthroscopic Rotator Cuff
Status: RECRUITING
Conditions: Arthroscopic Rotator Cuff Repair
Interventions: DEVICE: Abduction external rotation brace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Alisertib (MLN8237) in Adults With Aggressive Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Diffuse Large B-cell Lymphoma|Mantle Cell Lymphoma|Burkitt's Lymphoma|T-cell Lymphoma, Excluding Primary Cutaneous T-cell Lymphoma|Transformed Follicular Lymphoma With ≥ 50% Diffuse Large Cell Component
Interventions: DRUG: Alisertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Tolerability of GX-I7 in Patients With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Locally Advanced or Metastatic Solid Tumors
Interventions: DRUG: GX-I7
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methotrexate and Mycophenolate Mofetil for UVEITIS
Status: COMPLETED
Conditions: Uveitis
Interventions: DRUG: Mycophenolate mofetil|DRUG: Methotrexate|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DPE Technique in Labor Epidural for Morbidly Obese Women
Status: COMPLETED
Conditions: Morbid Obesity|Labor Pain
Interventions: PROCEDURE: Dural puncture epidural (DPE)|PROCEDURE: Standard Epidural (EPL)|DRUG: Dural puncture epidural (DPE)|DRUG: Standard Epidural (EPL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Individualized Response to Vitamin D Treatment Study
Status: COMPLETED
Conditions: Characteristics That Modify the Response to Cholecalciferol Treatment
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Using Esomeprazole as a Diagnostic Test for GERD in Patients With NCCP
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: esomeprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Biventricular Pacing In Patients With Left Ventricular Dysfunction After Cardiovascular Surgery
Status: COMPLETED
Conditions: Cardiomyopathy|Heart Failure, Congestive|Thoracic Surgery
Interventions: DEVICE: Atrial synchronous bi-ventricular pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-based Music Therapy in Blind Elderly Women
Status: COMPLETED
Conditions: Mindfulness|Music Therapy|Blind|Elderly|Mood
Interventions: BEHAVIORAL: mindfulness-based music therapy|BEHAVIORAL: mindfulness-based therapy|BEHAVIORAL: routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavior Changing Intervention for Smokeless Tobacco and Betel Quid Use in Adolescents
Status: COMPLETED
Conditions: Oral Cavity Carcinoma
Interventions: BEHAVIORAL: BCI for SLT and BQ Use in Adolescents: A CRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Long-Term Study to Evaluate the Safety of Asoprisnil and Estrogen Administration to Postmenopausal Women
Status: COMPLETED
Conditions: Postmenopause
Interventions: DRUG: Asoprisnil/Premarin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Healozone Study to Evaluate the Safety and Efficacy of the Use of Ozone for Management of Dental Caries
Status: COMPLETED
Conditions: Dental Caries
Interventions: DEVICE: Ozone treatment|DEVICE: Placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Citrullinemia for the Prediction of Enteral Nutrition Tolerance Among Critically Ill Patients
Status: UNKNOWN
Conditions: Enteral Nutrition|Intensive Care Unit|Biomarkers
Interventions: DRUG: N2-L-Alanyl-L-Glutamine (Substance)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Guided Imagery Intervention for Obese Latino Adolescents
Status: COMPLETED
Conditions: Obesity|Insulin Resistance|Metabolic Syndrome
Interventions: BEHAVIORAL: Guided Imagery|BEHAVIORAL: Digital Storytelling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Umbilical Cord Blood for Stem Cell Transplantation in Treating Young Patients With Malignant or Nonmalignant Diseases
Status: UNKNOWN
Conditions: Childhood Langerhans Cell Histiocytosis|Fanconi Anemia|Leukemia|Lymphoma|Myelodysplastic Syndromes|Neuroblastoma|Sarcoma|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: anti-thymocyte globulin|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: fludarabine phosphate|DRUG: melphalan|DRUG: methylprednisolone|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Darunavir/Ritonavir and Rosuvastatin Pharmacokinetic Study
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: darunavir, ritonavir, rosuvastatin|DRUG: rosuvastatin, darunavir, ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoxygenation Using High Flow Oxygen : Efficacy and Tolerance in Healthy Volunteers
Status: UNKNOWN
Conditions: Anesthesia|Airway Morbidity|Safety Issues
Interventions: PROCEDURE: preoxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab & Brentuximab Vedotin Consolidation After Autologous SCT in Patients With High-Risk Classical Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Classic Hodgkin Lymphoma|Recurrent Hodgkin Lymphoma|Refractory Hodgkin Lymphoma
Interventions: DRUG: Brentuximab Vedotin|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pentostatin, Cyclophosphamide, and Rituximab With or Without Bevacizumab in Treating Patients With B-Cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: bevacizumab|BIOLOGICAL: pegfilgrastim|BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: pentostatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploration of Glutamatergic System With PET Radiotracer in Gilles de la Tourette Patients: Pilot Study (GlutaTour)
Status: RECRUITING
Conditions: Tourette Syndrome
Interventions: DIAGNOSTIC_TEST: Experimental MRI exam and PET scan exam with radiotracer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Retifanlimab and Epacadostat in Combination With Radiation and Bevacizumab in Patients With Recurrent Gliomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioma|Glioblastoma
Interventions: DRUG: Epacadostat|DRUG: Bevacizumab|RADIATION: Radiation therapy|PROCEDURE: Peripheral blood draw|DRUG: Retifanlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Quadrivalent Influenza Vaccine GSK2282512A When Administered to Children From 6 to 35 Months of Age
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: FluLaval® Quadrivalent|BIOLOGICAL: Fluzone®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Two Algae Formulations on Lipid Metabolism, Inflammation and Oxidative Stress Status in Individuals With Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DIETARY_SUPPLEMENT: Corn starch|DIETARY_SUPPLEMENT: Unique Marine Algae Concentrate (UMAC)|DIETARY_SUPPLEMENT: Golden brown algae
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Role of Multi-modality Imaging in the Assessment of Chemotherapy Related Cardiac Dysfunction Among Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: 2D Speckle Tracking Echocardiography|Breast Cancer|Cardiac Magnetic Resonance
Interventions: DEVICE: Two dimensions speckle tracking and three dimension echocardiography and cardiac magnetic resonance imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Best Management of Sigmoid Volvulus: A Prospective Randomized Trial
Status: COMPLETED
Conditions: Intestinal Volvulus|Colon, Sigmoid
Interventions: PROCEDURE: Resection and anastomosis|PROCEDURE: Resection and colostomy|PROCEDURE: Mesosigmoidopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Switch From Tacrolimus to Cyclosporin in the Treatment of Recurrent Hepatitis C After Liver Transplantation
Status: TERMINATED
Conditions: Chronic Hepatitis C|Evidence of Liver Transplantation
Interventions: DRUG: ciclosporin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: " Comparative Evaluation of Aggressive Gap Arthroplasty With Minimal Gap Arthroplasty in the Management of TMJ Ankylosis "
Status: RECRUITING
Conditions: Arthoplasty
Interventions: OTHER: minimal gap arthoplasty v/s aggressive gap arthoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Memory T-cell Infusion to Improve Immunity After TCR-alpha/Beta Depleted Hematopoietic Stem Cell Transplantation
Status: COMPLETED
Conditions: Precursor T-Cell Lymphoblastic Leukemia-Lymphoma|Leukemia, Myeloid, Acute|Immune Deficiency Disease|Bone Marrow Failure Syndromes|Opportunistic Infections|Graft vs Host Disease
Interventions: BIOLOGICAL: CD45RA-depleted peripheral blood mononuclear cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Screening for Albuminuria at the First Line for Early Identification of CKD
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Albuminuria
Interventions: DIAGNOSTIC_TEST: Albuminuria test|DIAGNOSTIC_TEST: HbA1c test|DIAGNOSTIC_TEST: Creatinine test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Between Percutaneous Femoral Nerve Neuromodulation Associated With Femoral Nerve Block and Standard Clinical Practice in Patients Undergoing Knee Arthroplasty.
Status: RECRUITING
Conditions: Acute Pain
Interventions: DEVICE: Percutaneous neuromodulation using the EPTE® Bipolar System device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Controlled Phase 2/3 Study of Adjuvanted Recombinant SARS-CoV-2 Trimeric S-protein Vaccine (SCB-2019) for the Prevention of COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: CpG 1018/Alum-adjuvanted SCB-2019 vaccine|BIOLOGICAL: Placebo; 0.9% saline|BIOLOGICAL: SCB-2019 vaccine|BIOLOGICAL: SCB-2019 vaccine for Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I Dose Escalation Study of Intravenously Administered S64315 in Combination With Orally Administered Venetoclax in Patients With Acute Myeloid Leukaemia.
Status: COMPLETED
Conditions: Acute Myeloid Leukaemia
Interventions: COMBINATION_PRODUCT: S 64315 (also referred as MIK665) and venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Videolaryngoscopy and Direct Laryngoscopy in Pediatric Airway Management
Status: COMPLETED
Conditions: Airway Management|Videolaryngoscopy
Interventions: DEVICE: King Vision aBlade|DEVICE: direct laryngoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vancomycin Dose Adjustments Comparing Trough Levels to The AUC/MIC Method Using a Bayesian Approach in a Hospitalized Adult Population
Status: COMPLETED
Conditions: Vancomycin|Adult|Area Under Curve
Interventions: OTHER: Vancomycin dose adjustment using the Bayesian method|OTHER: Vancomycin dose adjustment using the trough level method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Assessing PTI-428 Safety, Tolerability, and Pharmacokinetics in Subjects With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: PTI-428|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Role of 13cis Retinoic Acid in the Treatment of COVID-19 and Enhancement of Its Spike Protein Based Vaccine Efficacy and Safety.
Status: UNKNOWN
Conditions: Covid19 Vaccine
Interventions: DRUG: Oral 13 cis retinoic acid|DRUG: Aerosolized 13 cis retinoic acid|COMBINATION_PRODUCT: 13 cis retinoic acid doses orally in combination with spike protein based vaccine|COMBINATION_PRODUCT: Aerosolized 13 cis retinoic acid in combination with spike protein based vaccine|BIOLOGICAL: Biological: spike protein based vaccine such as ChAdOx1 nCoV-19 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Accelerated Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Pulse or Continuous UV-A Light
Status: RECRUITING
Conditions: Keratoconus|Corneal Ectasia
Interventions: DRUG: riboflavin ophthalmic solution|DRUG: riboflavin ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Evaluate the Safety, Tolerability, and Immunogenicity of UB-313 in Healthy Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Migraine
Interventions: BIOLOGICAL: UB-313|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assess Safety & Reactogenicity of GSK Biologicals' Hib Vaccine Co-administered With or Without Chinese DTPw Vaccine
Status: COMPLETED
Conditions: Haemophilus Influenzae Type b Disease
Interventions: BIOLOGICAL: Haemophilus Influenza type b vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Optimization of Treatment and Management of Schizophrenia in Europe
Status: COMPLETED
Conditions: Schizophrenia|Schizophreniform Disorder|Schizoaffective Disorder
Interventions: DRUG: Amisulpride open label|DRUG: 6-week amisulpride double blind treatment|DRUG: 6-week olanzapine double blind treatment|DRUG: 12-week clozapine open-label treatment|BEHAVIORAL: Psychosocial intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Additional Minocycline Pleurodesis After Thoracoscopic Procedures for Primary Spontaneous Pneumothorax
Status: UNKNOWN
Conditions: Pneumothorax
Interventions: DRUG: intrapleural minocycline instillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zoledronate or Observation in Maintaining Bone Mineral Density in Patients Who Are Undergoing Surgery to Remove Both Ovaries
Status: COMPLETED
Conditions: Hereditary Breast and Ovarian Cancer Syndrome|Osteoporosis|Ovarian Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Zoledronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nortriptyline for Idiopathic Gastroparesis
Status: COMPLETED
Conditions: Idiopathic Gastroparesis
Interventions: DRUG: Nortriptyline Hydrochloride|DRUG: Placebo (for nortriptyline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multicentre Randomised Study Comparing a Taurolidine Lock and a Standard Saline Lock in Paediatric Oncology
Status: RECRUITING
Conditions: Children|Medical Device|Primary Prevention|Oncology
Interventions: DEVICE: TaurolockTM|DEVICE: Physiological serum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Thymosin Alpha 1 on Improving Monocyte Function for Sepsis
Status: COMPLETED
Conditions: Sepsis
Interventions: DRUG: thymosin alpha 1|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Precision Treatment With Angiotensin Converting Enzyme Inhibitor
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: genotyping and selection of renin-angiotensin system blocker|DRUG: Perindopril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Single and Multiple Ascending Dose Study of LTG-001 Administered Orally in Healthy Participants
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: LTG-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dapsone Use in Patients With Aneurysmal Subarachnoid Hemorrhage.
Status: COMPLETED
Conditions: Subarachnoid Hemorrhage|Brain Ischemia|Subarachnoid Hemorrhage, Aneurysmal|Aneurysmal Subarachnoid Hemorrhage|Delayed Cerebral Ischemia|Vasospasm, Cerebral
Interventions: DRUG: Dapsone|DRUG: Aluminum Hydroxide Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Use of Amplified Sound Signal to Identify Presence of Carotid and Femoral Stenosis
Status: TERMINATED
Conditions: Carotid Stenosis|Femoral Arterial Stenosis|Carotid Bruit Asymptomatic|Carotid Murmur
Interventions: DEVICE: AudioDoc
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy , Safety of Treatment R NIMP for Relapsed Aggressive Lymphomas
Status: COMPLETED
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: rituximab|DRUG: vinorelbine|DRUG: ifosfamide|DRUG: Mitoxantrone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Three Types of Dual-task Interventions on Dual-task Walking Performance of Stroke Patients
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: MCDTT|DEVICE: MDTT|DEVICE: CDTT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of KCl Plus 0.9%NaCl Compare With KCl Plus 0.45%NaCl
Status: UNKNOWN
Conditions: Hypokalemia
Interventions: OTHER: KCl plus 0.9%NaCl|OTHER: KCl plus 0.45%NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture-Like Transcutaneous Electrical Nerve Stimulation in Treating Radiation-Induced Xerostomia in Patients With Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Carcinoma|Xerostomia
Interventions: OTHER: Quality-of-Life Assessment|PROCEDURE: Transcutaneous Acupoint Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of TAK-853 in Adult Participants With Folate Receptor Alpha-Positive Advanced Ovarian Cancer And Other Solid Tumors
Status: RECRUITING
Conditions: Ovarian Cancer|Solid Tumors
Interventions: DRUG: TAK-853
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parasternal vs. Sternotomy Approach for Conventional Aortic Valve Replacement
Status: UNKNOWN
Conditions: Aortic Valve Stenosis
Interventions: PROCEDURE: Aortic valve replacement due to sternotomy|PROCEDURE: Aortic valve replacement due to parasternal right anterior mini-thoracotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Immediate Effects of Passive Hip Joint Mobilization on Hip Muscle Strength in Patients With Anterior Knee Pain
Status: COMPLETED
Conditions: Anterior Knee Pain Syndrome|Patellofemoral Pain Syndrome
Interventions: OTHER: Joint Mobilization|OTHER: Laying on of Hands
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bridge: Proactive Psychiatry Consultation and Case Management for Patients With Cancer
Status: COMPLETED
Conditions: Cancer|Severe Major Depression|Schizophrenia|Bipolar Disorder|Lung Cancer|Breast Cancer|Head and Neck Cancer|Gastrointestinal Cancer
Interventions: OTHER: Proactive Psychiatry Consultation (PPC)|OTHER: Enhanced Usual Care (EUC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Safety and Efficacy Study of RX-0201 Plus Gemcitabine in Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: RX-0201 plus Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Types of Manual Therapy Techniques in Patients With Chronic Neck Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: PROCEDURE: Manipulation|PROCEDURE: Mobilization|PROCEDURE: Mobilization with movement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proactive Population Health Strategy to Offer Tobacco Dependence Treatment to Smokers
Status: COMPLETED
Conditions: Smoking, Tobacco
Interventions: BEHAVIORAL: Internal Care Coordination|BEHAVIORAL: External Community Referral|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Apatinib in Neoadjuvant Therapy for Patients With Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Apatinib|DRUG: paclitaxel|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Association Between Epidural Labor Analgesia and Pregnancy Outcomes
Status: UNKNOWN
Conditions: Labor Pain|Pregnancy Outcomes|Psychological Disorder
Interventions: DRUG: Ropivacaine Hydrochloride, Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Therapy in Nipples Injured During Breastfeeding
Status: COMPLETED
Conditions: Nipple Trauma
Interventions: RADIATION: low-level laser on nipples
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Calcaneal Fracture Fixation vs Standard Lateral Approach
Status: COMPLETED
Conditions: Calcaneus Fracture
Interventions: PROCEDURE: Lateral extensile approach in calcaneal fractures fixation|PROCEDURE: Minimally invasive sinus tarsi approach in calcaneal fractures fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: In Vitro and In Vivo Comparison Between Intravascular Ultrasound (IVUS) Systems
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Infraredx Test Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Post-marketing Surveillance to Assess the Safety and Effectiveness of Zirabev in Domestic Patients With Various Cancer
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer|Metastatic Colorectal Cancer|Metastatic Breast Cancer|Metastatic Kidney Cancer|Cervical Cancer|Epithelial Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Cancer
Interventions: DRUG: Zirabev
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SNF Platform Study of HR+/ HER2-advanced Breast Cancer
Status: RECRUITING
Conditions: Breast Neoplasm|Breast Cancer|Hormone Receptor Positive Tumor|HER2-negative Breast Cancer|Advanced Breast Cancer
Interventions: DRUG: PIK3CA inhibitor|DRUG: AKT inhibitor|DRUG: Carrelizumab|DRUG: Famitinib|DRUG: Fluzoparib|DRUG: Dalpiciclib|DRUG: SHR-A1811|DRUG: TROP2 ADC|DRUG: Everolimus|DRUG: Aromatase Inhibitors or Fulvestrant|DRUG: Goserelin|DRUG: TPC|DRUG: RTK Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Effectiveness of Dynamic Stabilization Versus Lumbar Fusion in Treatment of Multilevel Lumbar Disc Degeneration Disease
Status: UNKNOWN
Conditions: Lumbar Spine Disc Degeneration
Interventions: PROCEDURE: Posterior Dynamic Stabilization|PROCEDURE: Internal Fixation and Fusion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Upper Extremity Strengthening on Functionality, Muscle Strength and Trunk in Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Upper Extremity Dysfunction|Upper Extremity Functions|Muscle Strength|Cerebral Palsy, Spastic|Cerebral Palsy Spastic Diplegia
Interventions: OTHER: traditional physiotherapy approach|OTHER: muscle strengthening exercise/Proprioceptive Neuromuscular Facilitation (PNF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Watch-and-Wait Approach With Dostarlimab in Localized dMMR/MSI-H Gastric Cancer: GERCOR Phase II Study
Status: RECRUITING
Conditions: Adenocarcinoma - GEJ|Gastric Adenocarcinoma
Interventions: DRUG: Dostarlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Semen Incubation With ANDROSITOL®DGN on Sperm Motility and Mitochondrial Membrane Potential
Status: COMPLETED
Conditions: Asthenozoospermia|Mitochondrial Damage
Interventions: DIAGNOSTIC_TEST: ANDROSITOL®TEST
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Healing on Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Healing|OTHER: Sham healing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Creon Use in Coeliac Patients With Low Faecal Pancreatic Elastase
Status: TERMINATED
Conditions: Patients With Coeliac Disease and Chronic Diarrhoea (>3 Loose/ Liquid Motions a Day for More Than 4 Weeks)|Patients With Pancreatic Exocrine Insufficiency
Interventions: DRUG: Creon|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Vestibular Rehabilitation Program on Dizziness, Vertigo and Balance in Population With Vertigo
Status: COMPLETED
Conditions: Vertigo
Interventions: OTHER: Cawthrone and cooksey exercises,Epley's repositioning maneuver will be performed also cervical stretches with basic balance exercises.|OTHER: Epley's repositioning maneuver will be performed also cervical stretches with basic balance exercises.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DEB-TACE, Lenvatinib and Anti-PD(L)1 Antibody as Conversion Therapy for Intrahepatic Cholangiocarcinoma
Status: RECRUITING
Conditions: Cholangiocarcinoma Non-resectable
Interventions: PROCEDURE: drug eluting beads-transcatheter arterial chemoembolization|DRUG: envatinib plus anti-PD(L)1
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the Effect of Regional Nerve Blocks on Pain and Inflammation After Video Assisted Thorascopic Lung Surgery
Status: TERMINATED
Conditions: Pain
Interventions: PROCEDURE: Thoracic Paravertebral Nerve Block|PROCEDURE: Thoracic Paravertebral Nerve Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: GPC3 Targeted CAR-T Cell Therapy in Advanced GPC3 Expressing Hepatocellular Carcinoma (HCC)
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Hepatocellular Cancer|Metastatic Hepatocellular Carcinoma
Interventions: DRUG: Cyclophosphamide|BIOLOGICAL: CAR-T cell|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of of Glecaprevir/Pibrentasvir in Adults With Chronic Hepatitis C Virus (HCV) Genotype 5 or 6 Infection
Status: COMPLETED
Conditions: Hepatitis C Virus (HCV)
Interventions: DRUG: Glecaprevir/Pibrentasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: T Cells Expressing Fully-human Anti-CD19 and Anti-CD20 Chimeric Antigen Receptors for Treating B-cell Malignancies and Hodgkin Lymphoma
Status: TERMINATED
Conditions: Lymphoma, B-Cell|Lymphoma, Non-hodgkins|Chronic Lymphocytic Leukemia|B-Cell Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: Anti-cluster of differentiation 19 (CD19)-Chimeric Antigen Receptors (CAR) and Anti-cluster of differentiation 20 (CD20)-CAR T cells|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclobenzaprine Extended Release (ER) for Fibromyalgia
Status: TERMINATED
Conditions: Fibromyalgia|Pain|Sleep|Fatigue
Interventions: DRUG: cyclobenzaprine ER (AMRIX)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Mass Balance Study With a Microtracer Dose of 14C-esketamine in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Esketamine 50 mg|DRUG: Esketamine 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Safety and Tolerability of KH658 Gene Therapy in Subjects With Neovascular Age-related Macular Degeneration (nAMD)
Status: NOT_YET_RECRUITING
Conditions: Age-related Macular Degeneration
Interventions: DRUG: KH658
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Tibia Fractures a Comparative Study Between Biplane External Fixator and Locked Intramedullary Nail
Status: COMPLETED
Conditions: Open tíbia Fracture
Interventions: PROCEDURE: External fixator|PROCEDURE: Intramedullary nail
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increasing Medical and Nursing Students Searching of Current Best Evidence to Answer Clinical Questions
Status: COMPLETED
Conditions: Medical and Nursing Students' Evidence Retrieval Skills
Interventions: BEHAVIORAL: Intervention A - Online Clinical Questions Recorder|BEHAVIORAL: Intervention B - Online Evidence Retrieval Coach|BEHAVIORAL: Intervention C - Online Audit and Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Comparing Haloperidol and Olanzapine in Treating Terminal Delirium
Status: RECRUITING
Conditions: Delirium|Terminal Illness
Interventions: DRUG: Haloperidol Solution|DRUG: Olanzapine Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of 2D and 3D Laparoscopy in Laparoscopic Pancreaticoduodenectomy: a Prospective Randomized Clinical Trial
Status: UNKNOWN
Conditions: Pancreatoduodenectomy
Interventions: PROCEDURE: 3D Laparoscopic pancreatoduodenectomy|PROCEDURE: 2D Laparoscopic pancreatoduodenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Mechanical Ventilation and Postoperative Pulmonary Complications After On-pump Cardiac Surgery in High-risk Patients
Status: RECRUITING
Conditions: Postoperative Pulmonary Complications
Interventions: PROCEDURE: Intervention group_MRA|PROCEDURE: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Safety and Efficacy Study of Mepolizumab in Subjects With Severe Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Mepolizumab 100 milligrams|DRUG: Placebo|DRUG: Salbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability Study of 4 Different Formulations of PF-07321332 Relative to the Commercial Tablet Formulation
Status: COMPLETED
Conditions: Bioavailability
Interventions: DRUG: PF-07321332/ritonavir|DRUG: PF-07321332/ritonavir|DRUG: PF-07321332/ritonavir|DRUG: PF-07321332/ritonavir|DRUG: PF-07321332
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mind-Body Intervention in Glioma Couples
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma|Low Grade Glioma|Malignant Glioma|Metastatic Malignant Neoplasm in the Brain|Partner|WHO Grade III Glioma
Interventions: PROCEDURE: Mind-Body Intervention Procedure|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chemotherapy Plus Peripheral Stem Cell Transplant in Treating Patients Who Have Multiple Myeloma or Primary Systemic Amyloidosis
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: recombinant interferon alfa|BIOLOGICAL: sargramostim|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: melphalan|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed Disodium and Cisplatin in Treating Patients Who Are Undergoing Surgery for Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: pemetrexed disodium|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Drug Use for CKD Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Kidney Disease
Interventions: DRUG: angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, DPP-4 inhibitors, GLP-1 receptor agonists, SGLT2 inhibitors, calcium channel blockers, β Receptor blocker
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cardiomyopathy in DMD: Lisinopril vs. Losartan
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy (DMD)|Cardiomyopathy
Interventions: DRUG: Losartan|DRUG: Lisinopril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Qutenza®-Remodulin® in Pulmonary Arterial Hypertension Patients
Status: COMPLETED
Conditions: Pulmonary Hypertension|Pain
Interventions: DRUG: Qutenza|DRUG: Tegaderm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-intensity Focused Ultrasound (HIFU) for the Symptom Relief of Inoperable Abdominal Tumors
Status: UNKNOWN
Conditions: Symptomatic Abdominal Tumour
Interventions: DEVICE: High-intensity focused ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Systematic Use of DDAVP to Prevent Serum Sodium Overcorrection in Severe Hyponatremia
Status: NOT_YET_RECRUITING
Conditions: Hyponatremia
Interventions: DRUG: DDAVP|DRUG: Standard hyponatremia treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project RESIST: Increasing Resistance to Tobacco Marketing Among Young Adult Sexual Minority Women Using Inoculation Message Approaches
Status: COMPLETED
Conditions: Cigarette Smoking Behavior
Interventions: OTHER: Culturally tailored anti-smoking messages|OTHER: Non-culturally tailored interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Cabozantinib in Combination With 13-cis-Retinoic Acid in Children With Relapsed or Refractory Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: Cabozantinib|DRUG: 13-cis-retinoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT