pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Kinesiotape for Edema After Bilateral Total Knee Arthroplasty
Status: COMPLETED
Conditions: Arthroplasty Complications|Arthroplasty, Replacement, Knee
Interventions: DEVICE: Kinesio(R)Tape for edema control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Immune Checkpoint Inhibitor for Patients With Primary Untreated or Recurrent/Metastatic SCCHN
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma|Head and Neck Cancer|Head and Neck Cancer Metastatic
Interventions: DRUG: Nivolumab 480mg and surgical resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Permissive Hypercapnia on Oxygenation and Post-operative Pulmonary Complication During One-lung Ventilation
Status: UNKNOWN
Conditions: Thoracic Surgery
Interventions: OTHER: group 40|OTHER: group 50|OTHER: group 60
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Topical Curcumin Versus Topical Corticosteroid on Management of Oral Lichen Planus Patients
Status: UNKNOWN
Conditions: Oral Lichen Planus
Interventions: DRUG: Triamcinolone|DRUG: Turmeric paste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DNA Methylation for Screening Uterine Cervical Lesions
Status: UNKNOWN
Conditions: DNA Methylation|Uterine Cervical Cancer|High Grade Squamous Intraepithelial Lesions|Low Grade Squamous Intraepithelial Lesions
Interventions: DIAGNOSTIC_TEST: DNA methylation|DIAGNOSTIC_TEST: High-risk HPV|DIAGNOSTIC_TEST: TCT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of CS0159 in Subjects With NASH
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis (NASH)
Interventions: DRUG: CS0159 (Linafexor)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study Of Short Ragweed Pollen Sublingual-Oral Immunotherapy
Status: COMPLETED
Conditions: Allergy
Interventions: BIOLOGICAL: Short Ragweed Pollen Allergenic Extract|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Non-Squamous Non-Small Cell Carcinoma|Stage IIIB Lung Cancer AJCC v8|Stage IIIC Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Carboplatin|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Pembrolizumab|DRUG: Pemetrexed|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Steroid-Antiviral Treatment in Rehabilitation of Facial Palsy
Status: COMPLETED
Conditions: Facial Palsy
Interventions: DRUG: Steroids (Prednisolone) and Steroids plus Antiviral (Prednisolone + acyclovir)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neural Progenitor Cell and Paracrine Factors to Treat Hypoxic Ischemic Encephalopathy
Status: UNKNOWN
Conditions: Hypoxic-Ischemic Encephalopathy
Interventions: BIOLOGICAL: neural progenitor cell|BIOLOGICAL: Paracrine factors|BIOLOGICAL: progenitor cell and paracrine factors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Velopharyngeal Insufficiency Evaluation Post Cleft Palate Repair. Furlow With Buccinator Myomucosal Flap Versus Two Flap Palatoplasty
Status: NOT_YET_RECRUITING
Conditions: Cleft Palate
Interventions: PROCEDURE: • Furlow with buccinators myomucosal flap|PROCEDURE: • Two flap palatoplasty as von langenbeck technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tacrolimus Immunosuppressive Therapy After Kidney Transplantation
Status: COMPLETED
Conditions: Kidney Transplantation|Kidney Failure, Chronic|Renal Insufficiency, Chronic
Interventions: DRUG: Tacrolimus|DRUG: Mycophenolate Mofetil|DRUG: Methylprednisolone or equivalent|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ofatumumab and Bendamustine Followed by Maintenance Ofatumumab for Rituximab Relapsed Indolent B-cell Non-Hodgkin's Lymphoma (B-NHL)
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin
Interventions: BIOLOGICAL: Ofatumumab|DRUG: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of SCB-2019 in Children <18 Years of Age
Status: WITHDRAWN
Conditions: COVID-19
Interventions: BIOLOGICAL: Candidate vaccine, SCB-2019
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Use of Technological Advances to Prevent Smoking Relapse Among Smokers With PTSD
Status: COMPLETED
Conditions: PTSD|Smoking
Interventions: DRUG: Bupropion|DRUG: nicotine replacement therapy|OTHER: Smoking cessation counseling|BEHAVIORAL: mobile contingency management|OTHER: Stay Quit Coach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PPI vs H2RA in Patients With Helicobacter Pylori-Negative Idiopathic Bleeding Ulcers
Status: COMPLETED
Conditions: Peptic Ulcer
Interventions: DRUG: Lansoprazole|DRUG: Famotidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Open-Label Treatment With Randomization Observation, Investigator-Initiated Study, on the Duration and Efficacy of Jornay PM (Methylphenidate Hydrochloride Extended-Release Capsules) on Adult ADHD Symptoms and Executive Function and Emotional Regulation Throughout the Day Into Early Evening
Status: RECRUITING
Conditions: Attention-deficit/Hyperactivity Disorder
Interventions: DRUG: Methylphenidate Hydrochloride Extended Release Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BONCURE Study: A Study of Monthly Bonviva (Ibandronate) in Women With Post-Menopausal Osteoporosis on Bisphosphonate Therapy.
Status: COMPLETED
Conditions: Post-Menopausal Osteoporosis
Interventions: DRUG: Ibandronate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Post Intensive Care Syndrome Follow-up and Management Study: The ICU Recovery Answers Project
Status: NOT_YET_RECRUITING
Conditions: Post Intensive Care Syndrome|ICU Survivors|ICU Families
Interventions: OTHER: Telehealth follow-up of post-intensive care syndrome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Neo-CRT Followed Surgery Compared With Definitive CRT in Patients With Initial Unresectable ESO
Status: UNKNOWN
Conditions: Unresectable Esophageal Cancer
Interventions: RADIATION: Definitive Radiochemotherapy|PROCEDURE: Neoadjuvant Radiochemotherapy followed by surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Vitamin E to Treat Muscular Cramps in Patients With ALS
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DIETARY_SUPPLEMENT: Vitamin E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Inspiration Rise Time on Work of Breathing and Comfort of Conscious Patients on Mechanical Ventilation
Status: COMPLETED
Conditions: Mechanical Ventilation
Interventions: PROCEDURE: pressure support ventilation at 0, 5, and 10% IRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose:
Clinical trial: Study of Enasidenib and Venetoclax in IDH2-Mutated Blood Cancers
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|Relapsed Cancer|Refractory Cancer|IDH2 Gene Mutation
Interventions: DRUG: Enasidenib|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Sensitivity and Specificity of iStatis HBsAg Test at the Point-Of-Care Site Settings
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatitis B|Hepatitis B Infection
Interventions: DEVICE: iStatis HBsAg Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders
Status: COMPLETED
Conditions: Tobacco Use Disorder
Interventions: OTHER: Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g)|OTHER: E-Cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Neuromuscular Exercises and Dance Therapy on Physical Performance and Kinesiophobia Results in Geriatrics
Status: RECRUITING
Conditions: Geriatrics|Neuromuscular Exercise|Dance Therapy|Kinesiophobia
Interventions: BEHAVIORAL: Neuromuscular Exercise Group|BEHAVIORAL: Dance Therapy Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy Study of an Interactive Robot for the Rehabilitation of the Upper Limb in Acute Stroke Patients
Status: COMPLETED
Conditions: Acute Stroke
Interventions: OTHER: Robotic-assisted therapy|OTHER: Classical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled Sevoflurane for ARDS Prevention
Status: RECRUITING
Conditions: Acute Respiratory Distress Syndrome
Interventions: DRUG: Inhaled sedation with sevoflurane|DRUG: Intravenous sedation (current practice)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Oral Mucolytics on Tear Film and Ocular Surface
Status: COMPLETED
Conditions: In the Present Study, we Investigated the Effects of Oral Ambroxol on Tear Film and Ocular Surface.
Interventions: DRUG: Ambroxol hydrochloride (Mucopect®, 60 mg, Boehringer Ingelheim)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Efficacy and Safety of OsrHSA in Patients of Hepatic Cirrhosis With Hypoalbuminemia
Status: COMPLETED
Conditions: Hypoalbuminemia|Hepatic Cirrhosis
Interventions: DRUG: OsrHSA|DRUG: Plasbumin®-20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of First-line JS001 and Nab-paclitaxel Versus Palcelbo and Nab-Paclitaxel in Participants With Advanced Recurrent or Metastatic TNBC
Status: SUSPENDED
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: JS001，an engineered anti-PD-1 antibody|DRUG: Nab-Paclitaxel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Hypochondriasis With CBT and/or SSRI
Status: COMPLETED
Conditions: Hypochondriasis
Interventions: DRUG: Fluoxetine|BEHAVIORAL: Cognitive Behavioral Therapy (CBT)|OTHER: Supportive Therapy|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Parafilm to Prevent CLABSI in Pediatric Patients Undergoing HCT
Status: COMPLETED
Conditions: Central Line Associated Bloodstream Infections (CLABSI)|Bone Marrow Transplant
Interventions: DEVICE: Parafilm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety of Lower Scalp Cooling Temperature to Prevent Hair Loss From Chemotherapy in Breast Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Breast Cancer Stage I|Breast Cancer Stage II|Breast Cancer Stage III
Interventions: DEVICE: PAXMAN Scalp Cooler
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Optimal Angle of Mediolateral Episiotomy at Crowning of the Head During Labor
Status: COMPLETED
Conditions: Labor, Obstetric|Episiotomy
Interventions: PROCEDURE: change of medilateral angle line during crowning of the head
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Application of Transcutaneous Trigeminal Nerve Stimulation on Autism Spectrum Disorder
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DEVICE: Charge-Balanced, Symmetric Nerve Stimulation|DEVICE: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Single and Multiple Dose Study to Investigate Safety, Tolerability and Pharmacokinetics of JNJ-42165279 in Healthy Japanese Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-42165279|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Ventilatory Effects of THRIVE During EBUS
Status: COMPLETED
Conditions: Hypercapnia|Sedation Complication|High Flow Nasal Cannula
Interventions: DEVICE: THRIVE (High Flow Nasal Cannula)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: New Covered Stent (Willis) for the Endovascular Reconstruction of Intracranial Vessel Wall Defects Registry
Status: UNKNOWN
Conditions: Aneurysm, Intracranial|Carotid-Cavernous Sinus Fistula
Interventions: DEVICE: WILLIS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Web-Based Behavioral Intervention on Physical Activity Levels in Adolescents
Status: COMPLETED
Conditions: Health Behavior|Adolescent Behavior|Motivation
Interventions: BEHAVIORAL: Zamzee Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Trial Evaluating the Effects of a One-year Lifestyle Intervention in Obese Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Caloric restriction|BEHAVIORAL: Exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of High-Dose-Rate Endorectal Brachytherapy (HDRBT) in the Treatment of Locally Advanced Low Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: RADIATION: High-dose endorectal brachytherapy (HDRBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Intravascular Monitoring of Partial PRessure of Oxygen for Neonatal intensiVE Care Patients -2
Status: TERMINATED
Conditions: Catheter|Newborn, Infant, Disease|Lung Diseases
Interventions: DEVICE: Neosense Umbilical Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Oral Pilocarpine in the Treatment of the Dry Eye of Patients With Sjogrens Syndrome
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Pilocarpine Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Post Marketing Surveillance Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Lumbar Disc Herniation|Annular Disc Tear|Annular Tear of Lumbar Disc
Interventions: DEVICE: 6mm annular closure device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: RC48-ADC in Combination With Gemcitabine in High Risk NMIBC Subjects
Status: RECRUITING
Conditions: NMIBC
Interventions: DRUG: RC48-ADC in Combination with gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Pharmacokinetics and Safety of Varespladib in Subjects With Normal or Impaired Renal Function
Status: TERMINATED
Conditions: Renal Impairment
Interventions: DRUG: varespladib methyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Comparing SIBP-02 and Rituximab Combination With CHOP in Previously Untreated Subjects With CD20+ DLBCL
Status: COMPLETED
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: SIBP-02|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thrombolysis Endovascular Treatment of Pulmonary Embolism
Status: COMPLETED
Conditions: Pulmonary Embolism|Acute Pulmonary Embolism
Interventions: DRUG: recombinant tissue plasminogen activator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Cariprazine in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Cariprazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decitabine and Cedazuridine in Combination With Venetoclax for the Treatment of Patients Who Have Relapsed Acute Myeloid Leukemia After Donor Stem Cell Transplant
Status: RECRUITING
Conditions: Recurrent Acute Myeloid Leukemia
Interventions: DRUG: Venetoclax|DRUG: Decitabine|DRUG: Cedazuridine|PROCEDURE: Bone Marrow Aspiration and Biopsy|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of 3 mg Glimepiride Tablet in Indonesia Healthy Subjects
Status: COMPLETED
Conditions: Drug Use
Interventions: DRUG: Glimepiride|DRUG: Amaryl®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reducing Agitation in People With Dementia: the Customized Activity Trial
Status: COMPLETED
Conditions: Dementia
Interventions: BEHAVIORAL: Tailored Activity Program|OTHER: Home Safety and Education Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Decision Aid for the Improvement of Decision-Making in Patients With Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Non-Small Cell Carcinoma|Stage I Lung Cancer AJCC v8|Stage II Lung Cancer AJCC v8|Stage III Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8
Interventions: OTHER: Best Practice|OTHER: Informational Intervention|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Functional Improvement of Coronary Artery Narrowing by Cholesterol Reduction With a PCSK9 Antibody
Status: COMPLETED
Conditions: Coronary Artery Disease|Atherosclerosis of Coronary Artery
Interventions: DRUG: Evolocumab 140 MG/ML [Repatha]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Telavancin in the Treatment of Gram Positive Bloodstream Infections in Cancer Patients
Status: COMPLETED
Conditions: Infection|Bacteremia
Interventions: DRUG: Telavancin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
Status: RECRUITING
Conditions: Breast Neoplasms|Breast Cancer|Breast Tumors|Angiosarcoma|TNBC - Triple-Negative Breast Cancer|HER2-positive Breast Cancer|HER2-negative Breast Cancer|Hormone Receptor Positive Tumor|Hormone Receptor Negative Tumor|Early-stage Breast Cancer|Locally Advanced Breast Cancer
Interventions: DRUG: Standard Therapy|DRUG: AMG 386 with or without Trastuzumab|DRUG: AMG 479 (Ganitumab) plus Metformin|DRUG: MK-2206 with or without Trastuzumab|DRUG: AMG 386 and Trastuzumab|DRUG: T-DM1 and Pertuzumab|DRUG: Pertuzumab and Trastuzumab|DRUG: Ganetespib|DRUG: ABT-888|DRUG: Neratinib|DRUG: PLX3397|DRUG: Pembrolizumab - 4 cycle|DRUG: Talazoparib plus Irinotecan|DRUG: Patritumab and Trastuzumab|DRUG: Pembrolizumab - 8 cycle|DRUG: SGN-LIV1A|DRUG: Durvalumab plus Olaparib|DRUG: SD-101 + Pembrolizumab|DRUG: Tucatinib plus trastuzumab and pertuzumab|DRUG: Cemiplimab|DRUG: Cemiplimab plus REGN3767|DRUG: Trilaciclib with or without trastuzumab + pertuzumab|DRUG: SYD985 ([vic-]trastuzumab duocarmazine)|DRUG: Oral Paclitaxel + Encequidar + Dostarlimab (TSR-042) + Carboplatin with or without trastuzumab|DRUG: Oral Paclitaxel + Encequidar + Dostarlimab (TSR-042) with or without trastuzumab|DRUG: Amcenestrant|DRUG: Amcenestrant + Abemaciclib|DRUG: Amcenestrant + Letrozole|DRUG: ARX788|DRUG: ARX788 + Cemiplimab|DRUG: VV1 + Cemiplimab|DRUG: Datopotamab deruxtecan|DRUG: Datopotamab deruxtecan + Durvalumab|DRUG: Zanidatamab|DRUG: Lasofoxifene|DRUG: Z-endoxifen|DRUG: ARV-471|DRUG: ARV-471 + Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of Minimally Invasive "Tibial Tuberoplasty" Surgical Technique Versus Conventional Open Surgery for Tibial Plateau Fractures
Status: ACTIVE_NOT_RECRUITING
Conditions: Schatzker Type 2 or 3 Tibial Plateau Fracture
Interventions: DEVICE: Tibial Tuberoplasty|DEVICE: Open technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Predictive Value of Pre-TAVI Infrahissian Conduction Time in the Occurrence of Complete Atrioventricular Block
Status: RECRUITING
Conditions: Aortic Stenosis, Severe
Interventions: PROCEDURE: Transcatheter Aortic Valve Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rh-endostatin in Combination With Dacarbazine and Cisplatin as the First Line Therapy for Metastatic Melanoma
Status: UNKNOWN
Conditions: Melanoma
Interventions: DRUG: recombinant human endostatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GA 6: The Blood Glucose-lowering Effect of Glucose-dependent Insulinotropic Polypeptide
Status: COMPLETED
Conditions: Type2 Diabetes
Interventions: OTHER: Placebo|OTHER: GIP receptor antagonist|DRUG: DPP-4 inhibitor|OTHER: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multi-site, Longitudinal Trial Evaluating the Efficacy, Mechanisms, and Moderators of Service Dogs for Military Veterans With PTSD
Status: ENROLLING_BY_INVITATION
Conditions: Stress Disorders, Post-Traumatic|Combat Stress Disorders|Animal-Human Bonding
Interventions: OTHER: PTSD Service Dog
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality in Children With Hemiparesis
Status: COMPLETED
Conditions: Physical Disability
Interventions: OTHER: designed occupational therapy program|OTHER: Wii virtual reality games
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of JS026 and JS026 Together With JS016 for Treatment of COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: JS026/placebo|BIOLOGICAL: JS016/placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of the Effect of CK-1827452 Injection on Myocardial Efficiency
Status: TERMINATED
Conditions: Heart Failure
Interventions: DRUG: CK-1827452|DRUG: CK-1827452
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Photobiomodulation Therapy in Strength Training and Detraining in Humans
Status: UNKNOWN
Conditions: Muscle Strength
Interventions: DEVICE: PBMT|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Diagnostic Value of MRI-targeted Plus Index-lesion-ipsilaterally Systematic Biopsy for Biopsy-naive Men at Risk of Prostate Cancer: a Prospective, Multicenter, Paired, Non-inferiority Trial
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: Biopsy of the prostate and pathological diagnosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of the Lidoderm Patch Applied to Patients With Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: Lidoderm (Lidocaine 5% Patch)|DRUG: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Protection of Arteritic Patients by Remote Preconditioning
Status: UNKNOWN
Conditions: Obliterating Arteriopathy of the Lower Limbs
Interventions: PROCEDURE: Remote ischemic preconditioning|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: the Clinical Performance of a Moisture Resistant, M-TEG-P Phosphate Monomer Based Universal Adhesive (YAMAKIN TMR-Aquabond0) Compared to the Conventional Universal Adhesive (3m ESPE Single Bond Universal Adhesive)
Status: UNKNOWN
Conditions: Non-carious Cervical Lesions|Geriatric Patients
Interventions: OTHER: Bonding in NCCLs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Infusion of Lidocaine, Magnesium and Remifentanil Perioperatively in Patients Undergoing Mastectomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Remifentanil infusion|DRUG: Lidocaine infusion|DRUG: Magnesium sulphate infusion|DRUG: Magnesium sulphate and Lidocaine infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Eszopiclone Co-administered With Venlafaxine in Subjects With Major Depressive Disorder and Insomnia
Status: COMPLETED
Conditions: Major Depressive Disorder|Insomnia
Interventions: DRUG: Eszopiclone|DRUG: Placebo|DRUG: Venlafaxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetic and Pharmacodynamic of ID120040002 in Healthy Volunteers
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: ID120040002|DRUG: Compound-X|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influence of Monitoring the Depth of General Anesthesia Upon the Incidence of PONV and Emergence Delirium in Children Undergoing Endoscopic Adenoidectomy in General Anesthesia
Status: COMPLETED
Conditions: Postoperative Nausea|Postoperative Vomiting|Emergence Delirium
Interventions: OTHER: BIS monitor|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Incentive Spirometer and Diaphragmatic Breathing Exercise on ABG Measures in Post-CABG Patients
Status: COMPLETED
Conditions: Post Coronary Artery Bypass Grafting
Interventions: OTHER: Incentive spirometer plus Chest physiotherapy|OTHER: Diaphragmatic breathing exercise plus Chest physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Parents as Friendship Coaches for Children With ADHD
Status: COMPLETED
Conditions: ADHD
Interventions: BEHAVIORAL: Parental Friendship Coaching|BEHAVIORAL: Coping with ADHD through Relationships and Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Gait Robotics to Improve Symptoms of Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Dementia|Mild Cognitive Impairment
Interventions: OTHER: Exoskeleton exercise|OTHER: Standard exercise|OTHER: No treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of Second Generation VIR-7831 Material in Non-hospitalized Participants With Mild to Moderate COVID-19
Status: COMPLETED
Conditions: Covid19
Interventions: BIOLOGICAL: Sotrovimab (Gen1)|BIOLOGICAL: Sotrovimab (Gen2)|BIOLOGICAL: Sotrovimab (Gen2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medicinal vs. Orthotic Comparison for Migraine Prevention: A Double-Blind Study
Status: UNKNOWN
Conditions: Migraine
Interventions: DRUG: Fremanezumab-Vfrm|DEVICE: BLAfit®|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Markers in Acute Pancreatitis-1
Status: RECRUITING
Conditions: Acute Pancreatitis Drug-Induced
Interventions: DIAGNOSTIC_TEST: Assessment of accuracy of microRNA and pancreatic enzyme markers in blood and/or urine in the detection and/or prediction of severity of drug-associated acute pancreatitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Efficacy and Safety of Boceprevir Added to Standard of Care Therapy in Previously Treated Participants With Chronic Hepatitis C Genotype 1 and Cirrhosis (MK-3034-105)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: boceprevir|BIOLOGICAL: PegIFN-2b|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Digital Articulation Versus Hand-articulation Accuracy for Occlusal Registration in Orthognathic Surgery
Status: RECRUITING
Conditions: Dentoalveolar Deformities
Interventions: PROCEDURE: hand occlusal articulation|PROCEDURE: digital occlusal articulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of the LEVAmethod by Bertz et al © in Subjects With Overweight or Obesity in Primary Health Care.
Status: RECRUITING
Conditions: Overweight and Obesity
Interventions: BEHAVIORAL: LEVAmethod by Bertz et al
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Atezolizumab in Combination With Bevacizumab Compared With Sorafenib in Patients With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Carbon Dioxide Insufflation and Water Exchange on Post-Colonoscopy Outcomes
Status: COMPLETED
Conditions: Abdominal Pain
Interventions: OTHER: Carbon dioxide method|OTHER: Water Exchange-CO2|OTHER: Water Exchange-AI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Adjuvant vs Surgery Only in Early-stage Recurrent NPC
Status: RECRUITING
Conditions: Recurrent Nasopharyngeal Carcinoma
Interventions: DRUG: Immunotherapy,Toripalimab Injection|DRUG: Chemotherapy,Gemcitabine based regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Tamiflu® (Oseltamivir) in Patients Receiving Extracorporeal Membrane Oxygenation (ECMO)and or Continuous Venovenous Hemodialysis (CVVHD)
Status: COMPLETED
Conditions: Critically Ill Renal Failure Requiring CVVHD and Oseltamivir|Critically Ill Requiring ECMO and Oseltamivir
Interventions: PROCEDURE: pharmacokinetic blood sampling|PROCEDURE: pharmacokinetic blood and dialysate sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral and Topical Tranexamic Acid for the Treatment of Melasma
Status: UNKNOWN
Conditions: Melasma|Chloasma|Melanosis
Interventions: DRUG: Oral Tranexamic Acid|DRUG: 5% topical tranexamic acid|DRUG: 4% hydroquinone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of FCN-411 in Advanced Non-small Cell Lung Cancer Chinese Patients With EGFR Positive Mutation
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: FCN-411 Dose-escalation|DRUG: FCN-411 Dose-expansion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Administration Of Tranexamic Acid And Acute Blood Loss In Patients With Hip Fractures
Status: WITHDRAWN
Conditions: Hip Fractures|Blood Loss
Interventions: DRUG: Tranexamic Acid Pill|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Blood Flow Restriction With Low-intensity Resistance Training Versus Traditional Resistance Exercise on Lower Limb Strength, Walking Capacity, and Balance in Patients With Ischemic Stroke: (BFR-Stroke RESILIENCE Trial)
Status: UNKNOWN
Conditions: Stroke, Ischemic|Cerebrovascular Accident
Interventions: OTHER: Low-intensity resistance exercise with blood flow restriction group (L-BFR)|OTHER: High-intensity resistance exercise without blood flow restriction group (H-BFR).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of [18F]RO6958948 as Tracer for Positron Emission Tomography (PET) Imaging of Tau Burden in Alzheimer's Disease Participants
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: [18F]RO6958948
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Osimertinib (AZD9291) in First-line Locally Advanced or Metastatic NSCLC Patients With EGFR and EGFR T790M
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Community Mobilization and Incentivization for Childhood Diarrhea and Pneumonia
Status: COMPLETED
Conditions: Childhood Diarrhea|Childhood Pneumonia|Community Mobilisation|Sanitation and Hygiene|Community Incentives
Interventions: BEHAVIORAL: Community Mobilization|BEHAVIORAL: Community Mobilization and Community Incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of 6 Months Treatment With Paricalcitol Injection or Oral in Patients With Secondary Hyperparathyroidism on Dialysis
Status: COMPLETED
Conditions: Secondary Hyperparathyroidism|Dialysis
Interventions: DRUG: Paricalcitol injection|DRUG: Paricalcitol capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis (Volunteer - BioD and Safety Study)
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DRUG: Cu[64]-25%CANF-Comb
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ventricular Tachycardia Ablation and Myocardial Scar Characterization With Magnetic Resonance
Status: UNKNOWN
Conditions: Ventricular Tachycardia|Myocardial Fibrosis
Interventions: PROCEDURE: Group 1, CMR-guided/aided VT ablation|PROCEDURE: Group 2, CMR-aided VT ablation|PROCEDURE: Group 3, Electroanatomical guided ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Enzyme Replacement Therapy (VPRIV) in People With Type 1 Gaucher Disease Who Were Previously Treated With Substrate Reduction Therapy
Status: COMPLETED
Conditions: Gaucher Disease
Interventions: OTHER: Digital Engagement Application (GD App)|OTHER: No Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of PRI-724 in Subjects With Advanced Myeloid Malignancies
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Chronic Myeloid Leukemia
Interventions: DRUG: PRI-724|DRUG: PRI-724|DRUG: PRI-724
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Axial Spondyloarthritis by Recombinant Human Tumor Necrosis Factor-α Receptor Ⅱ IgG Fc Fusion Protein
Status: COMPLETED
Conditions: Spondyloarthritis
Interventions: DRUG: 50mg Yisaipu|DRUG: 25mg etanercept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of Betalutin and Rituximab in Patients With FL
Status: COMPLETED
Conditions: Non Hodgkin Lymphoma|Follicular Lymphoma|Relapsed Follicular Lymphoma
Interventions: DRUG: 10 MBq/kg Betalutin|DRUG: 15 MBq/kg Betalutin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Effect of an Implant System With a Novel Abutment Attachment Design on Crestal Bone Preservation
Status: COMPLETED
Conditions: Partial Edentulism|Tooth Disease
Interventions: DEVICE: New Abutment Connection implant|DEVICE: Nanotite Certain Tapered implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The ORTIZ Study: Optimising RASi Therapy With SZC
Status: TERMINATED
Conditions: CKD|Diabetes Mellitus, Type 2|Hyperkalemia
Interventions: DRUG: Sodium Zirconium Cyclosilicate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Hepatitis C Testing and Treatment Among People Who Inject Drugs Attending Needle and Syringe Programs
Status: RECRUITING
Conditions: Hepatitis C|Hepatitis C, Chronic
Interventions: DIAGNOSTIC_TEST: Xpert HCV Viral Load Fingerstick|DIAGNOSTIC_TEST: Aptima HCV Quant DX Assay
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase I/II Trial of ATRA and TCP in Patients With Relapsed or Refractory AML and no Intensive Treatment is Possible
Status: UNKNOWN
Conditions: AML
Interventions: DRUG: Tranylcypromine|DRUG: Tretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Platelet Activation in Intracranial Aneurysm Rupture Risk - PLAQRAN
Status: ACTIVE_NOT_RECRUITING
Conditions: Intracranial Aneurysms|Ruptured Aneurysm
Interventions: OTHER: Collection of blood sample in aneurysm
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Family Support Protocol for Adolescent Internalizing Disorders
Status: NOT_YET_RECRUITING
Conditions: Internalizing Disorders|Substance Use Disorders
Interventions: BEHAVIORAL: Family Support Protocol for Adolescent Internalizing Disorders (Fam-AID)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Collect Information on the Characteristics of Elderly Belgian Patients With NVAF That Are Treated With a NOAC for This Indication With a Special Focus on Their Fear of Bleeding While Using a NOAC vs the Clinical Benefit of a NOAC of Thrombosis/Stroke Prevention.
Status: COMPLETED
Conditions: Non-Valvular Atrial Fibrillation
Interventions: DRUG: Non-VKA Oral Anticoagulants (NOAC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intensive Transcranial Magnetic Stimulation for Negative Symptoms in Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DEVICE: Transcranial Magnetic Stimulation|DEVICE: Transcranial Magnetic Stimulation with sham coil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Explorative Formulation of Insulin Degludec
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec|DRUG: placebo|DRUG: insulin degludec|DRUG: isophane human insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Magnetic Resonance Assessment for Heart Failure With Preserved Ejection Fraction
Status: COMPLETED
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: DIAGNOSTIC_TEST: Cardiac Magnetic Resonance, Echocardiogram, Blood investigation (NT-proBNP), cardiac catheterization|DIAGNOSTIC_TEST: Cardiac Magnetic Resonance, Echocardiogram, Blood investigation (NT-proBNP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Echinaforce Study to Investigate Explorative Pharmacology and Effectiveness to Prevent From Enveloped Virus Infections
Status: COMPLETED
Conditions: Respiratory Tract Infections|Common Cold
Interventions: DRUG: Echinaforce Chewable tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy in Treating Women With Stage I Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: epirubicin hydrochloride|DRUG: fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Electrical Stimulation for Hemiplegic Cerebral Palsy
Status: COMPLETED
Conditions: Hemiplegic Cerebral Palsy
Interventions: OTHER: FES neuroprosthesis to dorsiflexors on affected leg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT