pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Clinical Study That Will Assess the Effect of SEP-363856 or Prior Antipsychotic (PA) Standard of Care on Body-weight Associated Parameters in Subjects With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: SEP-363856|DRUG: Prior antipsychotic (risperidone, olanzapine, quetiapine or aripiprazole)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging of Intracerebral Inflammation in MS
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting|Multiple Sclerosis, Secondary Progressive|Multiple Sclerosis, Primary Progressive
Interventions: DRUG: 18F-DPA-714 and 18F-FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of Nutrition Supplementation and Education on the Healing of Diabetic Foot Ulcer (DFU)
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: DIETARY_SUPPLEMENT: glucose control nutritional shake, nutrition education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-world Effectiveness and Tolerability of Triptans-Ditans-Gepants (TRIDIGEP)
Status: RECRUITING
Conditions: Migraine|Migraine Disorders|Migraine With Aura|Headache Disorders
Interventions: DRUG: Patients with migraine treated with triptans, Lasmiditan or Gepants
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Delayed Cord Clamping in VLBW Infants
Status: COMPLETED
Conditions: Infant, Newborn|Infant, Low Birth Weight|Infant, Small for Gestational Age|Infant, Premature
Interventions: PROCEDURE: Standard Cord Clamping|PROCEDURE: Delayed Cord Clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Efficacy and Safety of Testosterone Gel in Adult Hypogonadal Males
Status: COMPLETED
Conditions: Adult Male Hypogonadism
Interventions: DRUG: Testosterone gel (FE 999303)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Feasibility and Safety Study of CD38 CAR-T Cell Immunotherapy for Relapsed B-cell Acute Lymphoblastic Leukemia After CD19 CAR-T Adoptive Cellular Immunotherapy
Status: UNKNOWN
Conditions: Relapsed B-cell Acute Lymphoblastic Leukemia After CD19 CAR-T ACI
Interventions: BIOLOGICAL: Specificity CD38 CAR-T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Halt cardiomyOPathy progrEssion in Duchenne (HOPE-OLE)
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: BIOLOGICAL: Allogeneic Cardiosphere-Derived Cells (CAP-1002)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apatinib and Irinotecan Combination Treatment in Esophageal Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Apatinib|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementing Virtual Reality (VR) to Reduce Sedation
Status: NOT_YET_RECRUITING
Conditions: Sedative During Endoscopy
Interventions: DEVICE: Pico 4 Enterprise headset with noise cancelling headphones
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk
Status: RECRUITING
Conditions: BRCA1 Mutation|POLD1 Gene Mutation|CDKN2A Mutation|BRCA2 Mutation|POLE Gene Mutation|APC Gene Mutation|ATM Gene Mutation|MLH1 Gene Mutation|BARD1 Gene Mutation|MSH2 Gene Mutation|BRIP1 Gene Mutation|MSH6 Gene Mutation|CHEK2 Gene Mutation|PMS2 Gene Mutation|PALB2 Gene Mutation|EPCAM Gene Mutation|RAD51C Gene Mutation|BMPR1A Gene Mutation|RAD51D Gene Mutation|SMAD4|PTEN Gene Mutation|GREM1
Interventions: BEHAVIORAL: Intervention Arm At-risk Relative/ARR Contacts|BEHAVIORAL: MyGene Portal|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficiency and Safety of the Prolonged Use of Heat and Moisture Exchangers in ICU
Status: RECRUITING
Conditions: VAP - Ventilator Associated Pneumonia
Interventions: OTHER: 72-hour HME exchange interval group|OTHER: 24-hour HME exchange interval group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Effects of Ziprasidone for the Treatment of Schizophrenia or Schizoaffective Disorder in Patients Who Were Switched From Other Antipsychotic Drugs
Status: COMPLETED
Conditions: Schizoaffective Disorder|Schizophrenia
Interventions: DRUG: Ziprasidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamics During Induction of General Anesthesia With High and Low Propofol Dose.
Status: COMPLETED
Conditions: Hemodynamics Instability|Anesthesia, General|Anesthesia, Intravenous
Interventions: DRUG: Propofol|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Standardization of Post-operative Opiate Prescriptions for Same-day Ankle and Wrist Fracture Surgeries
Status: UNKNOWN
Conditions: Opioid Use|Post-operative Pain|Prescription Opioid Abuse|Fracture, Ankle|Fracture Wrist|Surgery
Interventions: OTHER: Standardized opiate prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: UV1 Vaccination Plus Nivolumab and Ipilimumab in Treatment of Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: BIOLOGICAL: UV1|BIOLOGICAL: Sargramostim|BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMGN632 as Monotherapy or With Venetoclax and/or Azacitidine for Participants With CD123-Positive Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|DRUG: IMGN632|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial on NIraparib-TSR-042 (Dostarlimab) vs Physician's Choice CHEmotherapy in Recurrent, Ovarian, Fallopian Tube or Primary Peritoneal Cancer Patients Not Candidate for Platinum Retreatment
Status: RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: Niraparib|DRUG: Dostarlimab|DRUG: Pegylated liposomal doxorubicin|DRUG: Paclitaxel|DRUG: Gemcitabine|DRUG: Topotecan|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of IMPLANON and Radiopaque IMPLANON (34528)(P05720)
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Radiopaque Implanon|DRUG: Implanon (etonogestrel implant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Long-Term Safety and Tolerability of ETC-1002 in High-Risk Patients With Hyperlipidemia and High CV Risk (CLEAR Harmony)
Status: COMPLETED
Conditions: Hypercholesterolemia|Atherosclerotic Cardiovascular Diseases
Interventions: DRUG: ETC-1002|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Everolimus After (Chemo)Embolization for Liver Metastases From Digestive Endocrine Tumors
Status: COMPLETED
Conditions: Neuroendocrine Tumors|Hepatic Metastases|Metastases
Interventions: DRUG: Everolimus|DEVICE: embolization|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Confocal Laser Endomicroscopy in Digestive Diseases
Status: UNKNOWN
Conditions: Digestive System Diseases
Interventions: DEVICE: Confocal Laser Endomicroscopy (Pentax/Optiscan)|DEVICE: Narrow Band Imaging/Auto Fluorescence Imaging (Olympus)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Exploratory Clinical Study Non-invasive Monitoring of Cardiac Outputs
Status: COMPLETED
Conditions: Cardiac Output Measurements|Healthy Subjects
Interventions: DEVICE: Pulsify sensor|DEVICE: State-of-the-art ultrasound equipment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Closed Loop Stimulation for Neuromediated Syncope (SPAIN Study)
Status: UNKNOWN
Conditions: Syncope, Vasovagal
Interventions: DEVICE: Pacemaker with Closed Loop Stimulation (CLS sensor)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Plant Stanol Ester-Containing Spread on Estimated Cardiovascular Risk in Comparison to Mediterranean Diet
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: Stanol ester spread|DIETARY_SUPPLEMENT: Placebo spread|DIETARY_SUPPLEMENT: Mediterranean Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Diroximel Fumarate (DRF) in Chinese and Caucasian Adult Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Diroximel fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-emptive Scalp Infiltration With Dexamethasone Plus Ropivacaine for Postoperative Pain After Craniotomy
Status: COMPLETED
Conditions: Pain, Postoperative|Post-Craniotomy Headache
Interventions: DRUG: Miscible liquid of dexamethasone and ropivacaine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Glutamate Inhibitors in Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: Gabapentin|DRUG: Sulfasalazine|DRUG: Memantine|DRUG: Temozolomide|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The DESyne BDS Plus RCT: A Randomized Clinical Trial to Assess the Elixir DESyne BDS Plus Drug Eluting Coronary Stent System for the Treatment of de Novo Native Coronary Artery Lesions
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease
Interventions: COMBINATION_PRODUCT: Percutaneous Coronary Intervention with drug eluting stents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Improved Self-management for Patients on Ventricular Assist Device (VAD) Support - Phase 3
Status: COMPLETED
Conditions: Ventricular Assist Device|Psychosocial Factors|Self-management
Interventions: BEHAVIORAL: Self-management curriculum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Reducing Pain During Orogastric Tube Insertion in Newborns: Use of Pacifiers and Pacifiers Sweetened With 25% Dextrose
Status: COMPLETED
Conditions: Pain
Interventions: BEHAVIORAL: Pacifiers Group (İntervention Group 1)|BEHAVIORAL: Pacifier group sweetened with 25% dextrose (İntervention Group 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mitral Loop Cerclage(MLC) for Reducing Functional Mitral Regurgitation
Status: COMPLETED
Conditions: Functional Mitral Regurgitation|Heart Failure
Interventions: DEVICE: Mitral Loop Cerclage Annuloplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect and Cost Evaluation of a Multifaceted Approach With a Patient-centredness Questionnaire in Fertility Care
Status: UNKNOWN
Conditions: Patient Centredness|Quality of Life|Risk Factors for Emotional Maladjustment
Interventions: BEHAVIORAL: Multifaceted approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Safety and Efficacy Study of HPP404 on Weight Loss in Overweight or Obese Subjects
Status: TERMINATED
Conditions: Obesity|Overweight
Interventions: DRUG: HPP404|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tooth Bleaching for Young Patients Using a Hydrogen Peroxide-based Gel
Status: COMPLETED
Conditions: Tooth Discoloration
Interventions: OTHER: 35% hydrogen peroxide|OTHER: 35% hydrogen peroxide|OTHER: 20% hydrogen peroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: tDCS as an Adjuvant to Intensive Speech Therapy for Chronic Post Stroke Aphasia
Status: UNKNOWN
Conditions: Aphasia|Language
Interventions: DEVICE: Real tDCS|DEVICE: Sham tDCS|OTHER: Intensive Speech Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of NovaFerrum® vs Ferrous Sulfate Treatment in Young Children With Nutritional Iron Deficiency Anemia
Status: COMPLETED
Conditions: Iron Deficiency Anemia
Interventions: DRUG: elemental iron (NovaFerrum®)|DRUG: elemental iron (Ferrous Sulfate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on VCD/IE in the Patients With Ewing's Sarcoma Family of Tumors (ESFT)
Status: TERMINATED
Conditions: Ewing's Sarcoma
Interventions: DRUG: VCR, CTX, ADM; IFO, VP-16
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Primary Care and Prevention Services for Women Who Inject Drugs and Exchange Sex in Seattle, Washington
Status: RECRUITING
Conditions: Opioid Use Disorder|HIV Infections|Chlamydia|Gonorrhea|Syphilis|Trichomonas
Interventions: OTHER: Mobile Van Clinic
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Peripheral Nerve Blocks vs Periarticular Local Anesthetic Injection for Total Knee Arthroplasty (TKA)
Status: COMPLETED
Conditions: Total Knee Arthroplasty
Interventions: DRUG: Peripheral nerve blocks with Bupivacaine|DRUG: Intra articular injection with Ropivacaine|DRUG: Intra articular injection with liposomal bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Hematopoietic Cell Transplantation With Pegylated Interferon Alfa-2a for Primary and Secondary Myelofibrosis
Status: RECRUITING
Conditions: Myelofibrosis
Interventions: DRUG: Pegylated interferon alpha2a
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preemptive Therapy for SARS-Coronavirus-2 (COVID-19 PEP Canada)
Status: TERMINATED
Conditions: Corona Virus Infection|SARS-CoV Infection|Coronavirus
Interventions: DRUG: Hydroxychloroquine|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Icing and Airflow Stimulation in Obstructive Lung Diseases
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Group A-Diaphragmatic breathing|OTHER: Group B-Icing and Airflow Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Non-significant Risk Clinical Study: Changes in Perfusion After Therapeutic Ultrasound in Patients With PAD
Status: ACTIVE_NOT_RECRUITING
Conditions: Peripheral Arterial Disease (PAD)
Interventions: DEVICE: Therapeutic ultrasound (TUS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Explore the Safety, Tolerability, and Pharmacokinetics of AMG 305 in Subjects With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: AMG 305
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Physical Therapist as Primary Assessor for Patients With Knee Pain in Primary Care
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Physical therapy assessment|OTHER: Physician assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rotigotine Effect on All-day Functioning and Quality of Life in Subjects With Moderate to Severe Restless Legs Syndrome (RLS)
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: Rotigotine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Of The Effects Of Atorvastatin On Cholesterol Levels In Rheumatoid Arthritis Patients Taking CP-690,550
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: CP-690,550|DRUG: Atorvastatin|DRUG: CP-690,550|DRUG: Atorvastatin Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nasopharyngeal Versus Nasal Cannula Oxygen Supplementation in Surgery Patients
Status: COMPLETED
Conditions: Oxygen Administration During Deep Sedation
Interventions: DEVICE: Nasopharyngeal catheter|DEVICE: Nasal Cannula|PROCEDURE: Oxygen Supplementation|PROCEDURE: Sedation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Asthma-related Outcomes and Costs in Pediatric Subjects That Received Fluticasone Propionate, Budesonide or Montelukast in a Large Managed Care Population
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone propionate|DRUG: Budesonide|DRUG: Montelukast
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety Study to Assess Atomoxetine With MA Abusers and Healthy Controls
Status: COMPLETED
Conditions: Continuous Methamphetamine Dependence|Methamphetamine Dependence in Remission
Interventions: DRUG: Atomoxetine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bicarbonate Administration in Kidney Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplant; Complications|Metabolic Acidosis
Interventions: DRUG: Sodium Bicarbonate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Using Intensity-modulated Radiation Therapy in Patients With Nasopharynx Cancer to Permit Sparing of Contralateral Parotid Gland Function
Status: COMPLETED
Conditions: Nasopharyngeal Neoplasms
Interventions: PROCEDURE: Intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BrUOG 355: Nivolumab to Tailored Radiation Therapy With Concomitant Cisplatin in the Treatment of Patients With Cervical Cancer
Status: TERMINATED
Conditions: Cervical Cancer
Interventions: DRUG: Nivolumab induction|DRUG: Cisplatin|RADIATION: Radiation|DRUG: Nivolumab with chemoradiation|DRUG: Nivolumab maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Investigate The Pharmacokinetics, Safety And Tolerability Of An Intravenous And Oral Form Of A Compound In Subjects With Varying Degrees Of Renal Impairment And Normal Renal Function
Status: COMPLETED
Conditions: Pneumonia
Interventions: DRUG: CP-70,429 and PF-03709270
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Evaluation of Triple Antibiotic Paste Pulp Therapy Compared to Vitapex in Primary Molars.
Status: COMPLETED
Conditions: Dental Pulp Cavity
Interventions: DRUG: triple antibiotic paste (TAP)|DRUG: Vitapex (calcium hydroxide/iodoform paste)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Albuvirtide and 3BNC117 as Long-Acting Maintenance Therapy in Virologically Suppressed Subjects
Status: UNKNOWN
Conditions: HIV-1-infection
Interventions: DRUG: Albuvirtide|DRUG: 3BNC117|DRUG: Baseline ART
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LVGN6051 Combined With Anlotinib in Patient With Soft Tissue Sarcoma
Status: RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: COMBINATION_PRODUCT: LVGN6051 and Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydrogen-Oxygen Generator With Nebulizer for Adjuvant Treatment of COVID-19 Positive Patients
Status: UNKNOWN
Conditions: Covid19|Hydrogen-oxygen Gas|AMS-H-03
Interventions: DEVICE: Hydrogen-Oxygen Generator with Nebulizer, AMS-H-03|DEVICE: the hospital routine oxygen supply equipment (wall oxygen or cylinder oxygen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Liposomal Doxorubicin + Docetaxel + Trastuzumab + Metformin in Operable and Locally Advanced HER2 Positive Breast Cancer
Status: COMPLETED
Conditions: HER-2 Positive Breast Cancer
Interventions: DRUG: Liposomal doxorubicin|DRUG: Docetaxel|DRUG: Trastuzumab|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Cryotherapy in Managing Chemotherapy-Induced Peripheral Neuropathy in Children With Leukemia
Status: NOT_YET_RECRUITING
Conditions: Cancer
Interventions: DEVICE: Cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Electronic Cigarettes and Nicotine Pouches for Smoking Cessation
Status: NOT_YET_RECRUITING
Conditions: Role of Tobacco Harm Reduction in Smoking Cessation|Efficiency and Efficacy of E-cigarettes and Nicotine Pouches|Adverse Effect of E-cigarettes and Nicotine Pouches
Interventions: DEVICE: E-cigarettes device plus liquid|DRUG: Nicotine Pouches|OTHER: Basic care counseling about smoking cessation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pilot Study of Performance Status 2 vs. Performance Status 0-1 Non-small Cell Lung Cancer Patients Treated With Chemo/Immunotherapy
Status: RECRUITING
Conditions: Nonsmall Cell Lung Cancer|Performance Status
Interventions: DRUG: Pembrolizumab|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Nab paclitaxel|OTHER: Quality of Life Questionnaire, lung cancer-specific (QLQ-LC13)|OTHER: QLQ-C30 Global Health/Quality of Life Questionnaire|OTHER: COPD Assessment Test and modified Medical Research Council Dyspnea Patient Reported Outcomes|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mono Versus Polichemotherapy in Non Small Cell Lung Cancer (NSCLC) Elderly Patients
Status: TERMINATED
Conditions: NSCLC
Interventions: DRUG: Pemetrexed/Carboplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tamoxifen and Pegylated Liposomal Doxorubicin for the Treatment of Patients With Metastatic or Inoperable, Locally Advanced Triple Negative Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Locally Advanced Unresectable Triple-Negative Breast Carcinoma|Metastatic Triple-Negative Breast Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Echocardiography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Pegylated Liposomal Doxorubicin Hydrochloride|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Shigella Vaccine and Challenge
Status: COMPLETED
Conditions: Immunisation|Shigella Infection
Interventions: OTHER: Placebo|BIOLOGICAL: Shigella sonnei strain 53G|BIOLOGICAL: WRSs2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Role of Rosuvastatin on Vascular Involvement in Behçet's Disease
Status: COMPLETED
Conditions: Behcet's Disease
Interventions: DRUG: Rosuvastatin calcium 40mg|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Ranging Study to Evaluate the Safety and Efficacy of GSK2586184 in Patients With Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: 100 mg GSK2586184|DRUG: 200 mg GSK2586184|DRUG: 400 mg GSK2586184|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Two Flexible Extended Regimens of BAY86-5300 (SH T00186D) in Comparison With the Conventional Regimen of YAZ
Status: COMPLETED
Conditions: Contraception|Ovulation Inhibition|Contraceptives, Oral
Interventions: DRUG: EE20/DRSP (BAY86-5300)|DRUG: EE20/DRSP (BAY86-5300)|DRUG: EE20/DRSP (YAZ, BAY86-5300)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-Ascending and Multiple Doses of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Healthy Japanese Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Eplontersen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extended Follow Up of Young Women in Costa Rica Who Received Vaccine for Human Papillomavirus Types 16 and 18 and Unvaccinated Controls
Status: ACTIVE_NOT_RECRUITING
Conditions: Anal Carcinoma|Cervical Carcinoma|Human Papillomavirus Infection|Human Papillomavirus-Related Cervical Carcinoma|Oral Cavity Carcinoma
Interventions: OTHER: Cytology Specimen Collection Procedure|OTHER: Laboratory Biomarker Analysis|OTHER: Long-term Follow-up|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics and Safety of Single Subcutaneous Pasireotide (SOM230) in Subjects With Varying Degrees of Hepatic Function
Status: COMPLETED
Conditions: Hepatic Cirrhosis|Alcoholism
Interventions: DRUG: Pasireotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Aspects Associated With Obstructive Sleep Apnea, Bruxism and Orofacial Pain
Status: COMPLETED
Conditions: Bruxism|Temporomandibular Joint Disorders|Obstructive Sleep Apnea Syndrome
Interventions: DIAGNOSTIC_TEST: Evaluation of TMD and pain sensitivity|DIAGNOSTIC_TEST: Evaluation of SB|DIAGNOSTIC_TEST: Evaluation of AB
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Autologous Vaccination With Lethally Irradiated, Autologous Breast Cancer Cells Engineered to Secrete GM-CSF in Women With Operable Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: Autologous, Lethally Irradiated Breast Cancer Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of GST-HG151 Tablets in Healthy Volunteers
Status: UNKNOWN
Conditions: Healthy Volunteers
Interventions: DRUG: GST-HG151|DRUG: Placebo|DRUG: GST-HG151|DRUG: Placebo|DRUG: GST-HG151|DRUG: GST-HG151
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Infliximab Rheumatoid Arthritis Methotrexate Tapering (iRAMT) Protocol
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Remimazolam Tosilate and Midazolam in Elderly Patients Undergoing Gastrointestinal Endoscopy
Status: COMPLETED
Conditions: Elderly Patients|Gastrointestinal Endoscopy|Midazolam|Remimazolam
Interventions: DRUG: remimazolam tosilate group|DRUG: Midazolam group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multifocal Contact Lenses vs Bifocal Spectacles for Congenital Cataracts
Status: UNKNOWN
Conditions: Multifocal Contact Lenses
Interventions: DEVICE: short term Multifocal Contact Lenses|DEVICE: short term Bifocal Spectacles|DEVICE: long term Multifocal Contact Lenses|DEVICE: long term Bifocal Spectacles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of EFA in Acquired Brain Injury
Status: RECRUITING
Conditions: Acquired Brain Injury|Comparative Effectiveness Research|Lung Diseases, Obstructive
Interventions: DEVICE: Free Aspire with Expiratory Flow Accelerator (EFA) technology|DEVICE: In-Exufflator Machine|OTHER: Traditional respiratory treatment|OTHER: Traditional swallowing treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Orantinib In Combination With Transcatheter Arterial Chemoembolization In Patients With Unresectable Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Orantinib (TSU-68)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neural Correlates of Sensory Phenomena in Tourette Syndrome
Status: RECRUITING
Conditions: Tourette Syndrome|Sensory Disorders|Hypersensitivity|Tics
Interventions: DIAGNOSTIC_TEST: Electroencephalogram (EEG) testing procedure|DIAGNOSTIC_TEST: Autonomic function testing procedure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Comparing Denosumab vs. Zoledronic Acid for the Treatment of Bone Metastases in Breast Cancer Subjects.
Status: COMPLETED
Conditions: Bone Metastases
Interventions: BIOLOGICAL: Denosumab|DRUG: Zoledronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pre-op Chemo-RT w/CDDP/5FU vs Chemo w/ Docetaxel/Irinotecan in PET Non Responder Resectable Esophagus Cancer
Status: TERMINATED
Conditions: Carcinoma of Esophagus
Interventions: DRUG: irinotecan and docetaxel|DRUG: Cisplatin, fluorouracil and concurrent radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Omega-3 Fatty Acids in the Treatment of Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: Oral Omega-3-acid ethyl esters|DRUG: Placebo corn oil capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 1STST and Muscle Weakness in CF Patients
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DEVICE: Microfet Dynamometer|BEHAVIORAL: 1 minute sit to stand test|DEVICE: Accelerometer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of PErioperative PEmbrolizumab Treatment in Patients With Resectable Metastases From Kidney Cancer
Status: RECRUITING
Conditions: Oligometastatic Renal Cell Carcinoma
Interventions: DRUG: Pembrolizumab injection plus metastasis directed treatment (surgery or RT)|OTHER: Tumor resection or RT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topiramate 25 mg Capsules Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Topiramate Capsules, 25 mg|DRUG: Topamax® Capsules, 25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: High Intensity Focused Ultrasound Tumor Treatment for Pancreatic Cancer Pain
Status: SUSPENDED
Conditions: Pain|Pancreatic Adenocarcinoma|Ductal Adenocarcinoma
Interventions: PROCEDURE: High intensity focused ultrasound, HIFU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local and Systemic Antimicrobials in Non-surgical Periodontal Therapy
Status: COMPLETED
Conditions: Periodontitis
Interventions: PROCEDURE: Piperacillin and Tazobactam in gel form|PROCEDURE: Amoxicillin and Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploration of the Lipid Metabolism During the Diabetic Pregnancies
Status: COMPLETED
Conditions: Pregnancy|Pregnancy in Diabetes|Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus
Interventions: OTHER: blood tests|OTHER: diet questionnaire|OTHER: umbilical cord blood collect|OTHER: placenta collect
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Measurement of High Order Aberrations in Late Stages Keratoconus
Status: TERMINATED
Conditions: Keratoconus
Interventions: DEVICE: classic aberrometer and aberrometer AOVIS-1|DEVICE: Aberrometer AOVIS-I
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Feasibility of Combining Family and Cognitive Therapy to Prevent Chronic Anorexia
Status: COMPLETED
Conditions: Anorexia Nervosa
Interventions: BEHAVIORAL: FBT and CRT|BEHAVIORAL: FBT and art therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Ghrelin in Cancer Cachexia
Status: TERMINATED
Conditions: Cancer Cachexia
Interventions: DRUG: Anamorelin HCl|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data
Status: RECRUITING
Conditions: Perioperative Optimization
Interventions: DRUG: Neuraxial Analgesia|DRUG: Regional Block 1: Paravertebral|DRUG: Perphenazine|DRUG: Aprepitant|DRUG: Dimenhydrinate|DRUG: Ondansetron 4 MG|DRUG: Dexamethasone|DRUG: Regional Block 2: QL1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetic Interaction and Safety Between BR1018-1 and BR1018-2 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Hypertension|Hyperlipidemia (E.G., Hypercholesterolemia)
Interventions: DRUG: BR1018-1|DRUG: BR1018-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thoracic Spine Manual Traction With Mobilization Versus Manipulation
Status: COMPLETED
Conditions: Thoracic
Interventions: OTHER: Thoracic spine manual traction with mobilization protocol.|OTHER: Thoracic manipulation protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Case-Series Examination of a Brief CAT-Informed Intervention for Young People Experiencing Difficulties With Eating (RIDE)
Status: COMPLETED
Conditions: Eating Disorders
Interventions: BEHAVIORAL: Brief CAT-Informed Intervention for Young People experiencing Difficulties with Eating
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Soft-tissue Quadriceps Autograft ACL-reconstruction in the Skeletally-immature vs. Hamstrings
Status: RECRUITING
Conditions: ACL - Anterior Cruciate Ligament Rupture
Interventions: PROCEDURE: Soft tissue hamstring autograft|PROCEDURE: Quadriceps tendon autograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First-in-Human Study in Pediatric Patients With Ocular CLN2 Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Neuronal Ceroid Lipofuscinosis Type 2
Interventions: GENETIC: RGX-381
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lead EvaluAtion for Defibrillation and Reliability (LEADR) / Lead Evaluation for Defibrillation and Reliability in Left Bundle Branch Area Pacing (LEADR LBBAP)
Status: RECRUITING
Conditions: Tachyarrhythmia
Interventions: DEVICE: Defibrillation (RV Implant)|DEVICE: Defibrillation (LBBAP Implant)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rewarding Feedback in Motor Learning and Rehabilitation
Status: COMPLETED
Conditions: Motor Performance|Motor Learning
Interventions: BEHAVIORAL: Feedback about good performance|BEHAVIORAL: Feedback about good performance + money|BEHAVIORAL: Feedback about average performance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: CMAP Refinement for Pressure Injury Prevention
Status: RECRUITING
Conditions: Pressure Ulcer
Interventions: DEVICE: Use of CMAP app for education (in-hospital)|DEVICE: Use of CMAP app (in-home)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Whole Slide Image for Predicting the Novel Grading System of Resected Lung Adenocarcinoma
Status: RECRUITING
Conditions: Lung Adenocarcinoma|Whole Slide Image|Novel Grading System
Interventions: DIAGNOSTIC_TEST: Whole Slide Image based Deep Learning Signature
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Effectiveness of Two Treatments for Veterans With PTSD
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Interpersonal Therapy for PTSD|BEHAVIORAL: Prolonged Exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Renal Function Assessment in Critically Ill Children
Status: COMPLETED
Conditions: Iohexol|Pharmacokinetics|Renal Function|Critically Ill Children|Acute Kidney Injury|Augmented Renal Clearance
Interventions: DIAGNOSTIC_TEST: iohexol administration|DIAGNOSTIC_TEST: iohexol blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Topical Lidocaine/Prilocaine in Pain Management in Pleurocentesis
Status: RECRUITING
Conditions: Pleural Effusion
Interventions: DRUG: lidocaine 2.5% and prilocaine 2.5% cream in pain management before pleurocentesis.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation in Children With Attention Deficit Hyperactivity Disorder (ADHD). A Safety Study
Status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DEVICE: Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Twelve-Week Study of Varenicline for Safety and Efficacy in Comparison With Placebo and Zyban for Smoking Cessation
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: varenicline (CP-526,555)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Mindfulness Meditation for Subjects With Severe Speech and Physical Impairments
Status: COMPLETED
Conditions: Physical Impairments|Cerebral Palsy|Cerebral Ataxia|locked-in Syndrome
Interventions: BEHAVIORAL: Mindfulness Meditation Training|BEHAVIORAL: Audio Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gender Difference in sidE eFfects of ImmuNotherapy: a Possible Clue to Optimize cancEr tReatment
Status: COMPLETED
Conditions: Melanoma|Lung Cancer|Head and Neck Cancer|Urogenital Neoplasms|Breast Cancer
Interventions: DRUG: Immunotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Functional Magnetic Resonance Imaging (fMRI) Study of Nasal Strips in Nasal Congestion
Status: COMPLETED
Conditions: Nasal Congestion
Interventions: DEVICE: Test strip|DEVICE: Placebo strip|OTHER: Nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Quetiapine Augmentation Versus Clomipramine Augmentation of SSRI for Obsessive-compulsive Disorder Patients
Status: COMPLETED
Conditions: Obsessive Compulsive Disorder
Interventions: DRUG: Quetiapine|DRUG: Clomipramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Live@Home.Path: Innovating the Clinical Pathway for Home Dwelling Persons With Dementia and Their Families
Status: ACTIVE_NOT_RECRUITING
Conditions: Dementia|Home-dwelling|Caregiver
Interventions: BEHAVIORAL: LIVE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Natural History of Anterior Compartment Pressures of the Thigh Following Femur Fracture
Status: TERMINATED
Conditions: Femur Fracture
Interventions: DEVICE: Pressure monitoring device|DEVICE: Compartmental fracture pressure monitoring|DEVICE: This small project is designed to be a non-randomized, investigational prospective trial of compartment pressures in the thigh following femoral fracture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cardiorespiratory Fitness in Prediabetic,Type 2 Diabetic and Healthy Individuals
Status: COMPLETED
Conditions: Prediabetic State|Diabetes Mellitus, Type 2|Cardiorespiratory Fitness|Inflammation|Exercise Test
Interventions: DIAGNOSTIC_TEST: Cardiorespiratory Fitness
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of HFNC With NIV in Weaning COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease With (Acute) Exacerbation
Interventions: DEVICE: High flow nasal cannula|DEVICE: Noninvasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT