pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Mechanisms of Deep Vein Thrombosis (DVT) and Vein Wall Fibrosis
Status: RECRUITING
Conditions: Post-thrombotic Syndrome|Deep Vein Thrombosis Leg
Interventions: DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Artesunate Ointment for the Treatment of Anal HSIL in HIV-negative Participants
Status: RECRUITING
Conditions: Anal High-grade Squamous Intraepithelial Lesion|Anal HSIL|Anal HPV Infection
Interventions: DRUG: Artesunate ointment|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of Molecular Diagnostic Assays to Detect Cancer Biomarkers in Blood and Primary Tumor in HNSCC/NSCLC/Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma|Non Small Cell Lung Cancer|Melanoma
Interventions: DIAGNOSTIC_TEST: PD-L1 Kit
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Suvorexant to Treat Insomnia Related to Bipolar Disorder
Status: COMPLETED
Conditions: Insomnia|Bipolar Disorder
Interventions: DRUG: Suvorexant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MAGE-A10ᶜ⁷⁹⁶T for Urothelial Cancer, Melanoma or Head and Neck Cancers
Status: COMPLETED
Conditions: Urothelial Carcinoma|Head and Neck Cancer|Melanoma|Bladder Urothelial Carcinoma
Interventions: GENETIC: Autologous genetically modified MAGE A10ᶜ⁷⁹⁶T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Rescue of Hormonal Replacement Frozen Embryo Transfer Cycle With Low Serum Progesterone.
Status: RECRUITING
Conditions: Hormonal Replacement Frozen Embryo Transfer Cycle
Interventions: DRUG: Duphaston|DRUG: prolutex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inflammatory Response In Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Natalizumab|OTHER: Placebo: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: DNA Analysis of Tissue Samples From Patients With Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: GENETIC: cytogenetic analysis|GENETIC: gene expression analysis|GENETIC: mutation analysis|GENETIC: polymerase chain reaction|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: High Nucleotide Meal Consumption in Uric Acid and Metabolic Health
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Low nucleotide meal|OTHER: High nucleotide meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Body Scan Activity on Bone Marrow Transplant Patients and Their Caregivers
Status: TERMINATED
Conditions: Hematological Malignancy
Interventions: BEHAVIORAL: Body Scan|OTHER: Rotterdam Symptom Checklist|OTHER: Practice Logs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ACTIV-6: COVID-19 Study of Repurposed Medications - Arm E (Fluvoxamine 100)
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Fluvoxamine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of SB-743921 in Non-Hodgkin Lymphoma and Hodgkin Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma|Hodgkin's Disease
Interventions: DRUG: SB-743921|DRUG: SB-743921
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CBT-I Intervention for Insomnia in Newly Diagnosed Cancer Patients
Status: TERMINATED
Conditions: Cancer|Chronic Insomnia
Interventions: BEHAVIORAL: cognitive behavioral therapy for insomnia (CBTI)|BEHAVIORAL: Waitlist control condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects With Schizophrenia or Bipolar I Disorder
Status: RECRUITING
Conditions: Schizophrenia|Bipolar I Disorder
Interventions: DRUG: OLZ/SAM|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An International Randomized Trial of Additional Treatments for COVID-19 in Hospitalized Patients Who Are All Receiving the Local Standard of Care - WHO-SOLIDARITY-GERMANY
Status: UNKNOWN
Conditions: SARS-CoV-2 Infection|COVID-19|Moderate and Severe COVID-19
Interventions: OTHER: Standard of Care (SoC)|DRUG: Remdesivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation of Collaborative Self-management Services to Promote Physical Activity
Status: UNKNOWN
Conditions: Chronic Disease
Interventions: BEHAVIORAL: PreHabilitation|BEHAVIORAL: Rehabilitation in chronic stable patients in primary care|BEHAVIORAL: Rehabilitation in mild chronic patients and citizens at risk
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Abdominal Wall Reconstruction With PVDF Mesh in the Setting of Active Infection
Status: COMPLETED
Conditions: Abdominal Wall Defect|Abdominal Wall Hernia|Abdominal Wall Infection|Abdominal Wall Fistula|Infection
Interventions: PROCEDURE: Abdominal wall reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Investigating Safety,Tolerability,Pharmacokinetics and Antitumor Activities of HBM4003 Combine With Toripalimab
Status: UNKNOWN
Conditions: Solid Tumors
Interventions: DRUG: HBM4003 and Triprilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy and Tolerability of Black Cohosh Vs Tibolone in Patients With Menopausal Symptoms
Status: COMPLETED
Conditions: Menopause
Interventions: DRUG: Black Cohosh (iCR) or tibolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of L-Citrulline Supplementation on Arginase Activity and Vascular Function in Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: L-citrulline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Is Dexmedetomidine Associated With a Lower Incidence of Postoperative Delirium When Compared to Propofol or Midazolam in Cardiac Surgery Patients
Status: COMPLETED
Conditions: Delirium
Interventions: DRUG: Dexmedetomidine|DRUG: Propofol|DRUG: Midazolam
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Engage & Connect: A Psychotherapy for Postpartum Depression
Status: RECRUITING
Conditions: Postpartum Depression
Interventions: BEHAVIORAL: Engage & Connect (E&C)|BEHAVIORAL: Symptom Review and Psychoeducation (SRP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate GlaxoSmithKline (GSK) Biologicals' MenC-TT and Hib-MenC-TT or Meningitec™ in Healthy Toddlers
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: MenC-TT|BIOLOGICAL: Hib-MenC-TT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Exercise Program on Osteosarcoma Patients
Status: UNKNOWN
Conditions: Osteosarcoma
Interventions: OTHER: standard rehabilitation protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)
Status: RECRUITING
Conditions: Obesity
Interventions: DRUG: survodutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preliminary Study for Selective Detection of the CD8+ Myelin Specific T Cell in the Blood of Multiple Sclerosis Patients
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BIOLOGICAL: Blood samples|BIOLOGICAL: Blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Safety and Efficacy of BIBF 1120 at High Dose in Idiopathic Pulmonary Fibrosis Patients
Status: COMPLETED
Conditions: Pulmonary Fibrosis
Interventions: DRUG: placebo|DRUG: BIBF 1120
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Topical and Intravenous Tranexamic Acid in Surgical Treatment of Lumbar Degenerative Disease
Status: WITHDRAWN
Conditions: Lumbar Disc Degeneration|Surgical Procedure, Unspecified
Interventions: OTHER: Observational
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrical Vestibular Nerve Stimulation (VeNS) as a Treatment for Depression
Status: ACTIVE_NOT_RECRUITING
Conditions: Depression
Interventions: DEVICE: Modius Mood Active Device|DEVICE: Sham Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Absorption, Distribution and Elimination of Mirabegron After Oral Administration to Non-elderly Healthy Chinese Subjects
Status: COMPLETED
Conditions: Healthy Subjects|Plasma Concentration of Mirabegron
Interventions: DRUG: YM178 (mirabegron)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: CPX-351 and Ivosidenib for the Treatment of IDH1 Mutated Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome
Status: RECRUITING
Conditions: Acute Myeloid Leukemia With Gene Mutations|Myelodysplastic Syndrome|Myeloproliferative Neoplasm|Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Ivosidenib|DRUG: Liposome-encapsulated Daunorubicin-Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transspinal Stimulation Plus Locomotor Training for SCI
Status: RECRUITING
Conditions: Spinal Cord Injuries|Paraplegia, Spinal|Tetraplegia/Tetraparesis|Paraplegia, Spastic
Interventions: COMBINATION_PRODUCT: Standing transspinal stimulation followed by robotic gait training|COMBINATION_PRODUCT: Lying transspinal stimulation followed by robotic gait training|OTHER: Standing sham transspinal stimulation followed by robotic gait training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TL-925 as a Treatment for Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: TL-925|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acetyl-L-Carnitine Supplementation During HCV Therapy With Pegylated Interferon-α2b Plus Ribavirin
Status: COMPLETED
Conditions: Work Productivity and Activity Impairment in Workers With Chronic C Hepatitis|Fatigue in Workers With Chronic C Hepatitis|Fatigue
Interventions: DRUG: Acetylcarnitine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Study of Neuromuscular Exercise Therapy and Patients Self-management Program in Knee Osteoarthritis
Status: UNKNOWN
Conditions: Exercise Therapy
Interventions: BEHAVIORAL: Self-management program|BEHAVIORAL: Neuromuscular exercise therapy|BEHAVIORAL: Health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study Evaluating the Feasibility and Activity of Three Different Combination With Gemcitabine as First Line Therapy for Non Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Gemcitabine|DRUG: docetaxel|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Neoadjuvant Study of Enzalutamide, Abiraterone Acetate, Dutasteride and Degarelix in Men With Localized Prostate Cancer Pre-prostatectomy
Status: WITHDRAWN
Conditions: Prostate Cancer|Localized Prostate Cancer
Interventions: DRUG: Enzalutamide|DRUG: Abiraterone acetate|DRUG: Prednisone|DRUG: Dutasteride|DRUG: Degarelix
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maternal Brain Imaging in Opioid Use Disorder
Status: RECRUITING
Conditions: Opioid Use Disorder|Substance-Related Disorders|Substance Use|Pregnancy Related|Narcotic-Related Disorders|Buprenorphine Dependence
Interventions: DRUG: Buprenorphine|DIAGNOSTIC_TEST: Maternal Brain MRI|OTHER: Blood Samples|BEHAVIORAL: Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Synthetic vs Natural Estrogen in Combined Oral Contraception
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Ethinyl estradiol / dienogest|DRUG: Estradiol valerate / dienogest|DRUG: Dienogest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase II Study to Evaluate Safety and Efficacy of ALX-0061 in Subjects With Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Lupus Erythematosus, Systemic
Interventions: BIOLOGICAL: ALX-0061|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Muscle Specific and Movement Specific Muscle Energy Technique in the Management of Mechanical Neck Pain: a Randomized Controlled Trial.
Status: COMPLETED
Conditions: Neck Pain
Interventions: PROCEDURE: Muscle Specific Post Isometric Relaxation MET|PROCEDURE: Movement Specific Post Isometric Relaxation MET|PROCEDURE: unilateral postero-anterior glide|PROCEDURE: Heating and TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Does Craniosacraltherapy Have an Effect on Xerostomia and Other Late Sequelae on People Who Has Been Suffering From Cancer in Mouth and Throat?
Status: ACTIVE_NOT_RECRUITING
Conditions: Xerostomia Following Radiotherapy|Xerostomia Following in Neck Ore Head After Cancersurgery
Interventions: OTHER: cranio sacral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Neurodynamic Mobilization and Stretching Exercises for Chronic Discogenic Sciatica
Status: COMPLETED
Conditions: Physical Therapy
Interventions: OTHER: Slider, tensioner neurodynamic mobilization techniques and stretching exercises of back, hamstrings and gastrocnemius
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Belinostat (PXD101) to Treat Tumors of the Thymus at an Advanced Stage
Status: COMPLETED
Conditions: Thymoma|Thymic Carcinoma
Interventions: DRUG: Belinostat (PDX101)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testosterone and Myocardial Perfusion in Coronary Heart Disease (CHD)
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DRUG: Testosterone undecanoate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Stretching Protocol for Lateral Epicondylitis
Status: UNKNOWN
Conditions: Epicondylitis, Lateral|Elbow Tendinopathy|Epicondylitis of the Elbow|Epicondylitis
Interventions: OTHER: Passive and active analytical stretching exercises|OTHER: Static stretching of the extensor carpi radialis brevis and eccentric strengthening of the wrist extensor musculature
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Reactogenicity and Safety of Rotarix™ in Chinese Adults
Status: COMPLETED
Conditions: Infections, Rotavirus
Interventions: BIOLOGICAL: Rotarix ™|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Injection Pressure & Adductor Canal Block
Status: TERMINATED
Conditions: Orthopedic Disorders|Injury of Anterior Cruciate Ligament
Interventions: PROCEDURE: High Pressure Injection|PROCEDURE: Low Pressure Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Buprenorphine Induction for Fentanyl Dependent Opioid Users
Status: WITHDRAWN
Conditions: Opioid Dependence Fentanyl
Interventions: DRUG: Buprenorphine/naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Soft Contact Lens Attributes on Symptoms Associated With Digital Eye Strain in Symptomatic Soft Contact Lens Wearers
Status: COMPLETED
Conditions: Asthenopia|Myopia
Interventions: DEVICE: Contact lens with Multifocal Optics|DEVICE: Contact lens with Single Vision Optics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Physiotherapy for Radiation-induced Trismus
Status: COMPLETED
Conditions: Trismus|Radiation-induced Fibrosis
Interventions: DEVICE: Therabite|DEVICE: Hyperboloid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Responsiveness of Seven Functional Tasks in Patients With Poststroke Upper Limb Spasticity With Botulinum Toxin Type A Treatment
Status: COMPLETED
Conditions: Stroke|Muscle Spasticity
Interventions: BIOLOGICAL: Botulinum Toxin Type A|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study With Mirabegron 50 mg and 25 mg in Chinese Participants With Overactive Bladder
Status: COMPLETED
Conditions: Urge Incontinence|Overactive Bladder (OAB)
Interventions: DRUG: mirabegron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sentinel Lymph Node Biopsy in Rectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Rectal Cancer Stage III|Rectal Cancer Stage IV
Interventions: PROCEDURE: Sentinel lymph node biopsy|DRUG: Indocyanine green solution|DEVICE: fluorescence laparoscope|DIAGNOSTIC_TEST: pathological examination|DIAGNOSTIC_TEST: rapid frozen pathological examination|PROCEDURE: total mesorectal excision
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy, Safety of Hypertonic Lactate Soln. as Fluid Resuscitation Compared With Ringer's Lactate in Post-CABG Pats
Status: COMPLETED
Conditions: Low Cardiac Output
Interventions: DRUG: Hypertonic lactate|DRUG: Ringer's lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrated Parent Training for Treating Depression in Mothers of Children With Attention Deficit Hyperactivity Disorder
Status: COMPLETED
Conditions: Depression|Attention Deficit Disorder With Hyperactivity
Interventions: BEHAVIORAL: Integrated Parent Training|BEHAVIORAL: Behavioral Parent Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy, Radiation Therapy and Surgery for Esophageal Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of Esophagus|Squamous Cell Carcinoma of Esophagus
Interventions: DRUG: Cetuximab|DRUG: Cisplatin|DRUG: Irinotecan|DEVICE: Radiation therapy|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Renal Function in Adults Living With Obesity (TRIUMPH-OUTCOMES)
Status: RECRUITING
Conditions: Overweight and Obesity
Interventions: DRUG: Retatrutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Dermatological Evaluation: Acceptability With Gynecological Follow up - Dermacyd Delicata Pocket BR
Status: COMPLETED
Conditions: Hygiene
Interventions: DRUG: Lactic acid (Dermacid)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: DISCO: A Patient Intervention to Reduce the Financial Burden of Cancer
Status: RECRUITING
Conditions: Financial Toxicity|Cancer|Question Prompt List|Breast Cancer|Prostate Cancer
Interventions: BEHAVIORAL: Group 2: The DISCO App|BEHAVIORAL: Group 1: Usual Care|BEHAVIORAL: Group 3: The DISCO App + Booster
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Vitrectomy on the Evolution of Refractory Diabetic Macular Edema
Status: WITHDRAWN
Conditions: Edema|Macular Edema|Diabetic Retinopathy|Macular Degeneration|Diabetic Angiopathies|Retinal Disease
Interventions: PROCEDURE: Vitrectomy|PROCEDURE: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study of Metastatic Renal Cancer Using T-Cells Transduced With a T-Cell Receptor Which Recognizes TRAIL Bound to the DR4 Receptor
Status: TERMINATED
Conditions: Renal Cancer|Kidney Cancer
Interventions: GENETIC: 2G-1 TCR Retroviral Vector-Transduced lyn|DRUG: Aldesleukin|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: (PG13-A(F/K-F-SGSG-T2a-B (opt) (2G-1 TCR) retroviral vector-transduced lymphocyte
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor Stem Cell Transplant With No or Low-Intensity Chemotherapy Using Sirolimus and Treated Immune Cells to Treat Blood and Lymph Cancers
Status: TERMINATED
Conditions: Lymphoma|Leukemia|Myeloproliferative Disorders|Multiple Myleoma|Myelodysplastic Syndrome
Interventions: DRUG: Rituximab|DRUG: Fludarabine|DRUG: Etoposide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Cyclophosphamide|PROCEDURE: Peripheral blood stem cell (PBSC) transplantation|GENETIC: T cell donor lymphocyte infusion (DLI) with unmanipulated donor T cells|DRUG: Prednisone|PROCEDURE: Allogeneic hematopoietic stem cell transplant (HSCT)|DRUG: Filgrastim|GENETIC: T-Rapa cell Donor Lymphocyte Infusion (DLI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Exercise Therapy in Painful Shoulder Disorders
Status: UNKNOWN
Conditions: Shoulder Pain|Shoulder Disease|Balance; Distorted|Exercise
Interventions: OTHER: Shoulder Exercises|OTHER: Electrotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patterns of Neurodevelopmental Disorders
Status: RECRUITING
Conditions: Neurodevelopmental Disorders|Autism Spectrum Disorder|Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infection|Pediatric Acute-Onset Neuropsychiatric Syndrome|Down Syndrome|Epilepsy|Mitochondrial Encephalomyopathies|Cerebral Folate Deficiency
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase I, Study to Evaluate the Safety and Tolerability of Intravenous EZN-2208 in Patients With Advanced Solid Tumors or Lymphoma (EZN-2208-02)
Status: COMPLETED
Conditions: Lymphoma|Advanced Solid Tumors
Interventions: DRUG: EZN-2208
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Allogeneic Cells for the Treatment of Intermittent Claudication(IC)
Status: COMPLETED
Conditions: Intermittent Claudication|Peripheral Artery Disease
Interventions: BIOLOGICAL: PLX-PAD Low dose|BIOLOGICAL: PLX-PAD high doses|BIOLOGICAL: Double Placebo|BIOLOGICAL: high dose +Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy, Paclitaxel, and Carboplatin With or Without Trastuzumab in Treating Patients With Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma|Stage IB Esophageal Cancer AJCC v7|Stage IIA Esophageal Cancer AJCC v7|Stage IIB Esophageal Cancer AJCC v7|Stage IIIA Esophageal Cancer AJCC v7|Stage IIIB Esophageal Cancer AJCC v7
Interventions: DRUG: Carboplatin|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel|OTHER: Quality-of-Life Assessment|RADIATION: Radiation Therapy|PROCEDURE: Therapeutic Conventional Surgery|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of JVS-100 Administered to Adults With Ischemic Heart Failure.
Status: UNKNOWN
Conditions: Ischemic Heart Failure
Interventions: BIOLOGICAL: JVS-100 15 mg dose Injection|BIOLOGICAL: Placebo Injection|BIOLOGICAL: JVS-100 30 mg dose injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Agitated Saline Versus CXR Confirmation of Central Venous Lines
Status: UNKNOWN
Conditions: Central Venous Catheterization|Exposure to X-Rays
Interventions: PROCEDURE: Agitated Saline Method|PROCEDURE: chest x-ray
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Pain Managment in Chronic Shoulder Pain
Status: RECRUITING
Conditions: Chronic Pain Management
Interventions: OTHER: the effect of adding pulsed radiofrequency (PRF) modality to suprascapular nerve injection with ultrasound glenohumeral steroid in chronic shoulder pain patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Ecological Approach to Addressing Childhood Obesity Issues in Imperial County
Status: UNKNOWN
Conditions: Childhood Obesity
Interventions: BEHAVIORAL: Family wellness workshops|BEHAVIORAL: Obesity chronic care model|BEHAVIORAL: Physical activity, healthy eating, water drinking, healthy sleep promotion|BEHAVIORAL: Environment, policy, systems changes in clinic setting only|BEHAVIORAL: No intervention|BEHAVIORAL: Environment, policy, and systems changes in schools, early child care education & recreation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Race Impact on Efficacy of Niraparib Plus Abiraterone Acetate and Prednisone in Patients With Homologous Repair Deficient Castration-resistant Prostate Cancer
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer|Castrate Resistant Prostate Cancer|Homologous Recombination Deficiency
Interventions: DRUG: Niraparib/Abirate rone acetate fixed-dose combination|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Specific Antimicrobials and MIC Values on the Outcome of Bloodstream Infections Due to Extended-spectrum Beta-lactamase (ESBL) or Carbapenemase-producing Enterobacteriaceae: an Observational Multinational Study
Status: COMPLETED
Conditions: Clinically Significant Bacteremia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Impact tDCS-linked Motor and Cognitive Training Gains in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease|Cognition Disorder|Motor Disorders
Interventions: OTHER: Cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Radiation Therapy Plus Fluorouracil With or Without Additional Chemotherapy in Treating Patients With Primary Anal Cancer
Status: COMPLETED
Conditions: Anal Cancer
Interventions: DRUG: cisplatin|DRUG: fluorouracil|DRUG: mitomycin C|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Research About CD70-positive Advanced/Metastatic Solid Tumors Treated by CD70-targeted CAR-T
Status: RECRUITING
Conditions: Metastatic Tumor|Advanced Solid Tumor|Renal Cell Carcinoma|Ovarian Cancer|Cervix Cancer
Interventions: BIOLOGICAL: CD70 CAR-T cells|BIOLOGICAL: CD70 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression.
Status: COMPLETED
Conditions: Major Depression|Bipolar Disorder|Unipolar Depression
Interventions: DRUG: triiodothyronine|DRUG: sertraline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Community Wellness Program for Adults Living With Long-term Physical Disability
Status: COMPLETED
Conditions: Physical Disability
Interventions: BEHAVIORAL: EnhanceWellness for Disability (EW-D)|BEHAVIORAL: Wellness Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Clear Aligners Versus Fixed Appliances on Occlusion After Treatment of Mild Anterior Crowding
Status: ENROLLING_BY_INVITATION
Conditions: Occlusion
Interventions: DEVICE: Clear aligners|DEVICE: Fixed appliances
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: CT-FFR-guided Strategy for In-stent Restenosis
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease|In-stent Restenosis
Interventions: DIAGNOSTIC_TEST: CT-FFR|DIAGNOSTIC_TEST: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessment of Efficacy and Safety in Patients With Non-cancer-related Pain and Opioid-induced Constipation
Status: COMPLETED
Conditions: Opioid-Induced Constipation (OIC)
Interventions: DRUG: NKTR-118|DRUG: NKTR-118|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Preventional Drug Therapy on Pain Regulation Mechanisms Among SCI
Status: UNKNOWN
Conditions: Spinal Cord Injuries|Central Pain Syndrome
Interventions: DRUG: Pregabalin|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immune Response to Different Schedules of a Tetravalent Dengue Vaccine Given With or Without Yellow Fever Vaccine
Status: COMPLETED
Conditions: Dengue|Dengue Fever|Dengue Hemorrhagic Fever|Yellow Fever
Interventions: BIOLOGICAL: Live, attenuated, recombinant dengue serotypes 1, 2, 3, and 4 virus|BIOLOGICAL: Live, attenuated, recombinant dengue serotypes 1, 2, 3, and 4 virus|BIOLOGICAL: Live, attenuated, recombinant dengue serotypes 1, 2, 3, and 4 virus|BIOLOGICAL: Yellow Fever
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CONSISTENT 1: Metabolic and Safety Outcomes of Hylenex Recombinant (Hyaluronidase Human Injection) Preadministered at CSII Infusion Site in Participants With Type 1 Diabetes Mellitus (T1DM)
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Commercial Hylenex® recombinant (hyaluronidase human injection)|DRUG: Precommercial Hylenex recombinant (hyaluronidase human injection)|DRUG: Insulin lispro|DRUG: Insulin aspart|DRUG: Insulin glulisine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Proton Therapy With Immunotherapy in Multiple Metastases Cancer
Status: UNKNOWN
Conditions: Proton Therapy|Immunotherapy|Neoplasm Metastasis
Interventions: COMBINATION_PRODUCT: Radiation: Proton Therapy+PD-1 Ab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Circadian Light on Hospitalized Persons With Dementia and Older Adults With Cognitive Impairments.
Status: UNKNOWN
Conditions: Dementia|Cognitive Impairment
Interventions: OTHER: Naturalistic LED light|OTHER: Standard/traditional lighting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Seclidemstat and Azacitidine for the Treatment of Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia
Status: RECRUITING
Conditions: Chronic Myelomonocytic Leukemia-0|Chronic Myelomonocytic Leukemia-1|Chronic Myelomonocytic Leukemia-2|Myelodysplastic Syndrome|Recurrent Chronic Myelomonocytic Leukemia|Recurrent Myelodysplastic Syndrome
Interventions: DRUG: Azacitidine|DRUG: Seclidemstat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Two Different Oral Solutions Tipranavir Administered in Combination With Ritonavir to Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tipranavir|DRUG: Tipranavir|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BANCO Study: Behavioral Addictions and Related NeuroCOgnitive Aspects: A Monocentric, Prospective, Controlled, Open-label Study of a Sample of Patients With Gambling Disorder
Status: UNKNOWN
Conditions: Gambling Disorder
Interventions: BEHAVIORAL: Cognitive and clinical assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Paclitaxel With or Without Bevacizumab in Treating Patients With Locally Recurrent or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: bevacizumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D on the Honeymoon Period in Children and Adolescents With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Vitamin D|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Pharmacological Reversal of Neuromuscular Blockade in Critically Ill Patients
Status: RECRUITING
Conditions: Neuromuscular Blockade|Critical Illness|Neurologic Findings
Interventions: DRUG: Sugammadex|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating Devil's Claw for the Treatment of Hip and Knee Osteoarthritis
Status: TERMINATED
Conditions: Osteoarthritis, Knee|Osteoarthritis, Hip
Interventions: DRUG: Devil Claw|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Whole Body Vibration Therapy in a Participant With Multiple Sclerosis Related Balance Deficits - A Case Study
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DEVICE: Whole Body Vibration machine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a Booster Dose of Meningococcal Diphtheria Toxoid Conjugate Vaccine in Adolescents
Status: COMPLETED
Conditions: Meningitis|Meningococcemia
Interventions: BIOLOGICAL: Meningococcal Polysaccharide Diphtheria Toxoid Conjugate|BIOLOGICAL: Meningococcal Polysaccharide Diphtheria Toxoid Conjugate|BIOLOGICAL: Meningococcal Polysaccharide Diphtheria Toxoid Conjugate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Avastin in Combination With Chemotherapy for RAS Mutant Unresectable Colorectal Liver-limited Metastases
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: DRUG: avastin|DRUG: mFOLFOX6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gene Expression in Predicting Response to Paclitaxel in Patients With Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: GENETIC: cytogenetic analysis|GENETIC: gene expression analysis|GENETIC: microarray analysis|GENETIC: mutation analysis|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: immunohistochemistry staining method
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of Multiple Doses of ABT-333 Alone and in Combination With Pegylated Interferon (pegIFN) and Ribavirin (RBV) in Subjects With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection
Status: COMPLETED
Conditions: Chronic Hepatitis C Virus Infection
Interventions: DRUG: ABT-333|OTHER: Placebo for ABT-333|DRUG: Pegylated interferon|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Patellar Resurfacing in Total Knee Arthroplasty Leads to Better Isokinetic Performance and Higher Clinical Scores
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: patellar component
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Alemtuzumab Plus Peripheral Stem Cell Transplantation in Treating Patients With Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: alemtuzumab|BIOLOGICAL: filgrastim|DRUG: cyclophosphamide|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of Two Different Bevel Preparations in Class IV Lesions Using Nanofilled Composite
Status: ACTIVE_NOT_RECRUITING
Conditions: Class IV Dental Caries
Interventions: PROCEDURE: Tooth preparation in Class IV lesions with 2mm bevel|PROCEDURE: Tooth preparation in Class IV lesions with 2mm stair-step chamfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Woodsmoke Particulate + Prednisone
Status: COMPLETED
Conditions: Airway Inflammation
Interventions: DRUG: 60 mg Prednisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Turkish Version of Hand-Use-at-Home Questionnaire
Status: COMPLETED
Conditions: Cerebral Palsy|Brachial Plexus Palsy
Interventions: BEHAVIORAL: Hand-Use-at-Home Questionnaire (HUH)|BEHAVIORAL: Pediatric Outcome Data Collection Instrument (PODCI)|BEHAVIORAL: Children's Hand-Use Experience Questionnaire (CHEQ)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Outcomes of Phacoemulsification With Torsional Ultrasound
Status: COMPLETED
Conditions: Cataract
Interventions: PROCEDURE: Torsional ultrasound (INFINITI, Alcon, USA)|PROCEDURE: Longitudinal U/S (Infiniti system, Alcon, USA)|PROCEDURE: Longitudinal U/S (LEGACY 20000, Alcon, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Investigational Study to Assess the Effect of BMS-986177 on Aspirin in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Aspirin|DRUG: BMS-986177|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Docetaxel and Carboplatin in Treating Patients With Recurrent Stage IVB Squamous Cell Carcinoma (Cancer) of the Cervix
Status: TERMINATED
Conditions: Cervical Cancer
Interventions: DRUG: carboplatin|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial to Assess the Efficacy and Safety of Concomitant Use of Rifampicin and Efavirenz 600 X 800mg
Status: TERMINATED
Conditions: Tuberculosis|HIV Infections
Interventions: DRUG: efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety, Tolerability, and Pharmacokinetics of Topical Selinexor (KPT-330) Diabetic Foot Ulcer (DFU) Patients
Status: WITHDRAWN
Conditions: Diabetic Foot Ulcers
Interventions: DRUG: Selinexor|OTHER: Standard-of-Care|OTHER: Vehicle Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Recombinant Human Insulin-Like Growth Factor (rhIGF-1) Treatment of Short Stature Associated With IGF-1 Deficiency
Status: COMPLETED
Conditions: Insulin-Like Growth Factor-1 Deficiency|Growth Disorders
Interventions: DRUG: rhIGF-1 (mecasermin) for a period of 86 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Lidocaine Block in Children With Cerebral Palsy and Dysphagia
Status: NOT_YET_RECRUITING
Conditions: Cerebral Palsy
Interventions: BEHAVIORAL: routine rehabilitation treatment|PROCEDURE: Stellate ganglion block|DRUG: Lidocaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Lens Defogging Using Anti-fog Solution, waRm Saline, and Chlorhexidine Solution
Status: COMPLETED
Conditions: Gynecologic Disease
Interventions: DEVICE: Warm saline|DEVICE: anti-fog agent|DEVICE: chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Family Well-Being and Child School Readiness: Power PATH Dual Generation Intervention
Status: UNKNOWN
Conditions: Power PATH|Head Start as Usual
Interventions: BEHAVIORAL: Power PATH|OTHER: Head Start as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Clopidogrel Dose Adjustment According to Platelet Reactivity Monitoring in Patients With High on Treatment Platelet Reactivity Undergoing Percutaneous Coronary Intervention
Status: COMPLETED
Conditions: Acute Coronary Syndromes
Interventions: DRUG: PRASUGREL|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT