pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Long-Term Safety of Ragweed (Ambrosia Artemisiifolia) Sublingual Tablet (SCH 39641) in Adults With a History of Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (Study P05234)
Status: COMPLETED
Conditions: Rhinitis, Allergic|Conjunctivitis
Interventions: BIOLOGICAL: Ambrosia artemisiifolia allergen extract (Amb a 1-U)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Social Exclusion in The Context of Chronic Embitterment
Status: COMPLETED
Conditions: Emotional Stress|Embitterment
Interventions: OTHER: Cyberball: Other Exclusion|OTHER: Cyberball: Player Exclusion|OTHER: Mindfulness: Emotion Regulation Task|OTHER: Mindfulness: Word Recognition Task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab for the Treatment of Metastatic or Unresectable Solid Tumors With ARID1A Mutation and CXCL13 Expression
Status: RECRUITING
Conditions: Metastatic Malignant Solid Neoplasm|Unresectable Solid Neoplasm
Interventions: BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protecting Alzheimer Caregivers Using Technology Through Staying Sharp
Status: NOT_YET_RECRUITING
Conditions: Mild Cognitive Impairment|Dementia Alzheimers|Old Age; Dementia|Caregiver Burden|Health Behavior|Social Behavior|Caregiver Burnout
Interventions: BEHAVIORAL: Staying Sharp intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CONCEPT: Crossover Efficacy Pain Trial in Motor Cortex Stimulation for Intractable Neuropathic Pain
Status: TERMINATED
Conditions: Pain, Intractable|Facial Pain
Interventions: DEVICE: Cortical lead, 8 electrodes (Model 2976) with Synergy neurostimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: TNFalfa Blocking Treatment of Spondylarthropathies
Status: COMPLETED
Conditions: Spondylarthropathies|Ankylosing Spondylitis|Psoriatic Arthritis
Interventions: DRUG: Infliximab|DRUG: Etanercept|DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cefaliv® Compared to Neosaldina® in the Treatment of Migraine Attacks
Status: WITHDRAWN
Conditions: Migraine Headache
Interventions: DRUG: Cefaliv® & Placebo|DRUG: Neosaldina® & Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Maraviroc in Modulating Atherosclerosis in HIV Patients.
Status: COMPLETED
Conditions: HIV Infection With Other Conditions|Cardiovascular Risk Factor|Atherosclerosis|Inflammation
Interventions: DRUG: Maraviroc 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Retrolaminar Versus Erector Spinae Plane Block for Postoperative Analgesia
Status: RECRUITING
Conditions: Analgesia
Interventions: DRUG: ultrasound guided Retrolaminar Block|DRUG: ultrasound guided Erector Spinae Plane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compare Sirolimus Coated Balloon Catheter With Paclitaxel Coated Balloon Catheter in De Novo Coronary Bifurcated Lesions
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caspofungin Acetate, Fluconazole, or Voriconazole in Preventing Fungal Infections in Patients Following Donor Stem Cell Transplant
Status: COMPLETED
Conditions: Fungal Infection|Hematopoietic and Lymphoid Cell Neoplasm
Interventions: DRUG: Caspofungin Acetate|DRUG: Fluconazole|OTHER: Laboratory Biomarker Analysis|DRUG: Voriconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioequivalence Study of Oseltamivir Phosphate and TAMIFLU Under Fed Condition in Healthy Volunteers
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Oseltamivir Phosphate 75 mg capsules|DRUG: Tamiflu capsules 75 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of 3 Months of Selective Serotonin Reuptake Inhibitor (SSRI)-Treatment on Metabolism and Hypothalamic-pituitary-adrenal (HPA)-Axis in Young Men Born With Low Birth Weight
Status: COMPLETED
Conditions: Insulin Resistance|Low Birth Weight|Type 2 Diabetes|Cardiovascular Disease|Melancholic Depression|Anxiety Disorders
Interventions: DRUG: Escitalopram|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Functional Substrate-Only Guided VT Ablation
Status: NOT_YET_RECRUITING
Conditions: Ventricular Tachycardia|Sudden Cardiac Death
Interventions: PROCEDURE: Functional Substrate-Only Mapping without VT Induction|PROCEDURE: Standard-of-Care Mapping/Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tiotropium Plus Olodaterol vs Inhaled Corticosteroids (ICS) Regimens in the Portuguese Primary Care Setting (TIOLCOR Study)
Status: WITHDRAWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: TIO/OLO|DRUG: ICS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Postoperative Oral Corticosteroids Following Tonsillectomy
Status: UNKNOWN
Conditions: Tonsillectomy
Interventions: DRUG: Prednisolone|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Addition of Everolimus to Standard of Care in Carcinoma Gallbladder
Status: RECRUITING
Conditions: Gallbladder Cancer
Interventions: DRUG: Everolimus 10 mg|DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Anaesthetic Efficacy of 4% Articaine Buccal Infiltration Versus Inferior Alveolar Nerve Block
Status: NOT_YET_RECRUITING
Conditions: Restorative Dental Treatment by Buccal Infiltration Anaesthesia
Interventions: OTHER: 4% articaine infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dose-effect of SSR180575 in Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathies
Interventions: DRUG: SSR180575|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Capmatinib (INC280) in NSCLC Patients With MET Exon 14 Alterations Who Have Received Prior MET Inhibitor
Status: COMPLETED
Conditions: Malignant Non-small Cell Neoplasm of Lung Stage IV
Interventions: DRUG: Capmatinib (INC280)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of 5-HT3 Receptor Antagonist (Ramosetron) for the Treatment of Fecal Incontinence
Status: NOT_YET_RECRUITING
Conditions: Fecal Incontinence
Interventions: DRUG: Ramosetron|DRUG: Psyllium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial in Patients Who Have Suffered a Heart Attack and Who Have Undergone Catheterization Treated With Levosimendan
Status: UNKNOWN
Conditions: ST Elevation Myocardial Infarction
Interventions: DRUG: Levosimendan|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Regorafenib and Sintilimab in Combination With Electroacupuncture in MSS CRC
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer Metastatic
Interventions: DRUG: Regorafenib and Sintilimab in combination with electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computer-Assisted Treatment of Urinary Tract Infection in Emergency Departments and Community Health Centers
Status: TERMINATED
Conditions: Urinary Tract Infections
Interventions: OTHER: Computer-assisted treatment group|OTHER: Usual care group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of the Oral Stimulation Program in Extreme Preterm Infants
Status: COMPLETED
Conditions: Infant, Premature|Feeding Behavior
Interventions: OTHER: Intervention group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate Safety and Effectiveness of Cendakimab (CC-93538) in Participants With Moderate to Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis, Atopic|Eczema
Interventions: DRUG: CC-93538|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Hyperbaric Oxygen Treatment Increases Hepatic Insulin Sensitivity and Muscle Reactive Oxygen Species in T2D
Status: COMPLETED
Conditions: Type 2-diabetes
Interventions: DEVICE: 100% O2 in oxygen chamber|DEVICE: 21% O2 in oxygen chamber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DRUG: Dalcetrapib (RO4607381)|DRUG: Evidence-based medical care for Acute Coronary Syndrome|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of RC28-E Injection in Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: BIOLOGICAL: intravitreal injection of RC28-E|BIOLOGICAL: Conbercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Laser-modified Abutment Topography on Peri-implant Mucosal Integration
Status: UNKNOWN
Conditions: Dental Implant Failure Nos
Interventions: DEVICE: Laser-Lok abutment|DEVICE: Standard healing abutment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Acupuncture in the Response of the Median Neurodynamic Test
Status: COMPLETED
Conditions: Other Lesions of Median Nerve
Interventions: OTHER: Acupuncture therapy (leopard spot needling technique)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antimicrobial Effect OF Propolis Administrated Through Two Different Vehicles In High Caries Risk Children
Status: COMPLETED
Conditions: Early Childhood Caries
Interventions: COMBINATION_PRODUCT: Propolis chewing gum|COMBINATION_PRODUCT: Propolis mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of ANX007 in Participants With Primary Open-angle Glaucoma
Status: COMPLETED
Conditions: Open Angle Glaucoma
Interventions: BIOLOGICAL: 2.5mg ANX007|BIOLOGICAL: 5.0mg ANX007|OTHER: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early-life MRI Biomarkers of Longer-term Respiratory Morbidity in Infants Born Extremely Preterm (EMBLEM)
Status: RECRUITING
Conditions: Lung Function|BPD - Bronchopulmonary Dysplasia
Interventions: DIAGNOSTIC_TEST: Magnetic Resonance Imaging (MRI)|DIAGNOSTIC_TEST: Echocardiogram|DIAGNOSTIC_TEST: Lung ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Enzyme-containing Mouth Rinse on Dental Biofilm in Patients With Fixed Orthodontic Appliances
Status: UNKNOWN
Conditions: Caries
Interventions: PROCEDURE: Mouth rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment for Borderline Personality Disorder
Status: COMPLETED
Conditions: Borderline Personality Disorder
Interventions: BEHAVIORAL: Systems Training for Emotional Predictability and Problem Solving (STEPPS)|BEHAVIORAL: Treatment As Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lost Children Society (LCS), Online Therapeutic Tabletop Role-playing Game for Early-onset Schizophrenia Patients
Status: NOT_YET_RECRUITING
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Lost Children Society Game
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparative Results of Maxillary Deficiency Treatment by Tongue Plate and Facemask in Growing Patients
Status: COMPLETED
Conditions: Maxillary Deficiency
Interventions: OTHER: Tongue plate|OTHER: Facemask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b Study of Paclitaxel And Ricolinostat For The Treatment Of Gynecological Cancer
Status: TERMINATED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Carcinoma
Interventions: DRUG: Paclitaxel|DRUG: Ricolinostat|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction Chemotherapy Plus Chemoradiotherapy With or Without Aspirin in High Risk Rectal Cancer
Status: TERMINATED
Conditions: Rectal Cancer, Adenocarcinoma|Locally Advanced Malignant Neoplasm|Chemoradiation
Interventions: DRUG: Aspirin|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Patritumab in Combination With Erlotinib in Subjects With Locally Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC). (HER3-Lung)
Status: TERMINATED
Conditions: Lung Cancer|Non-small Cell Lung Cancer
Interventions: DRUG: Patritumab|DRUG: Erlotinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Respiratory Disorders Non-invasive Monitoring of Work of Breathing in Outpatients
Status: COMPLETED
Conditions: Copd|Asthma|Respiratory Effort|Contactless Vital Sign Monitoring
Interventions: DEVICE: Investigational Device: Contactless heart rate and respiratory rate monitor|DIAGNOSTIC_TEST: Heart Rate (EKG) Monitor|DIAGNOSTIC_TEST: Respiratory rate Monitor|DIAGNOSTIC_TEST: Pulse Oximetry
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effect of Chewing Gum and Drinking Fennel Tea
Status: COMPLETED
Conditions: Bowel Ileus|Cesarean Section Complications
Interventions: OTHER: Chewing gum group|OTHER: Fennel tea group|OTHER: Chewing gum+Fennel tea group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery
Status: COMPLETED
Conditions: Heart Failure|Acidosis, Lactic|Thiamine Deficiency
Interventions: DRUG: Vitamin B1-ratiopharm|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Effects Associated With the Administration of Akkermansia Muciniphila on Parameters of Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome x|Glucose Metabolism Disorders|Dyslipidemias|Obesity
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Live Akk 9|DIETARY_SUPPLEMENT: Live Akk 10|DIETARY_SUPPLEMENT: Killed Akk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Articaine and Prilocaine for Extraction of Maxillary Teeth
Status: COMPLETED
Conditions: Overcoming the Failure of Anaesthesia|Maxillary Teeth|Dental Extraction
Interventions: DRUG: Articaine 4%|DRUG: Prilocain 3%|DRUG: Adrenalin|DRUG: Felypressin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Maintenance and Cost Effectiveness of Cendres Metaux Locator (CM-LOC) Resin Matrix Versus Ball Nylon Matrix Attachment Retaining Single Implant Mandibular Complete Overdentures
Status: UNKNOWN
Conditions: Completely Edentulous
Interventions: DEVICE: cm-loc attachment|DEVICE: ball attachment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Lateral Crural Strut Graft vs Bone-Anchored Suspension for Treatment of Lateral Nasal Wall Insufficiency
Status: WITHDRAWN
Conditions: Nasal Valve Incompetence
Interventions: PROCEDURE: Lateral Crural Strut Graft|PROCEDURE: Bone Anchored Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Skin Immunity Sample Collection Involving Blisters and Biopsies
Status: ENROLLING_BY_INVITATION
Conditions: Hyper-Immunoglobulin E. Syndrome (HEIS)|Chronic Granulomatous Disease (CGD)
Interventions: OTHER: Blister induction|OTHER: Skin Biopsies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: 68GA-PSMA-11 PET/CT Scan in Impacting Treatment Strategies for Patients With Prostate Cancer
Status: COMPLETED
Conditions: Biochemically Recurrent Prostate Carcinoma|Metastatic Prostate Carcinoma|Prostate Adenocarcinoma|Prostate Carcinoma|PSA Level Greater Than Fifty|PSA Progression|Stage IV Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8|Stage IVB Prostate Cancer AJCC v8
Interventions: PROCEDURE: Computed Tomography|DRUG: Gallium Ga 68-labeled PSMA-11|PROCEDURE: Positron Emission Tomography|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The European Robotic Spinal Instrumentation (EUROSPIN) Study
Status: UNKNOWN
Conditions: Degenerative Disc Disease|Spondylolisthesis|Spinal Stenosis|Recurrent Disc Herniation|Spondylodiskitis|Spinal Tumor|Spinal Metastases
Interventions: PROCEDURE: Transpedicular Instrumentation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Double-dose Rabeprazole Accelerates and Sustains the Control of Symptoms in Patients With NERD
Status: WITHDRAWN
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: rabeprazole|DRUG: standard dose rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of tDCS and tUS on Pain Perception in OA of the Knee
Status: COMPLETED
Conditions: Chronic Pain|Osteoarthritis
Interventions: DEVICE: transcranial direct current stimulation (tDCS)|DEVICE: transcranial ultrasound (TUS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trochanteric Femur Fracture Operated With Dynamic Hip Screw System (DHS) Augmented With a Biphasic Apatite Sulphate Combined With Systemic or Local Bisphosphonate
Status: ACTIVE_NOT_RECRUITING
Conditions: Trochanteric Fracture of Femur
Interventions: PROCEDURE: OSTEOSYNTHESIS|DRUG: Zoledronic Acid|DEVICE: CERAMENT BONE VOID FILLER (BVF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Echocardiographic and Invasive Haemodynamic Measurements in the Assessment of Patients Low Flow Low Gradient Aortic Stenosis Undergoing TAVI
Status: COMPLETED
Conditions: Cardiovascular Abnormalities
Interventions: OTHER: Ultrasound|PROCEDURE: Catheters|PROCEDURE: Soft study wire|RADIATION: X-ray|DRUG: Dobutamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analysis of Human Tissue Temperature After Application of Therapeutic Modalities.
Status: COMPLETED
Conditions: Humans|Young Adult|Health
Interventions: OTHER: Coplanar|OTHER: Contraplanar|OTHER: Longitudinal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Dietary Sodium Intake on Vascular Endothelium
Status: COMPLETED
Conditions: Postural Tachycardia Syndrome (POTS)
Interventions: PROCEDURE: Pulsitile Arterial Tonometry (PAT) Protocol|DEVICE: Calf Blood Flow in Reactive Hyperemia (CBF-RH)|DEVICE: Evaluation of Forearm-Mediated Dilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hedgehog Inhibitors for Metastatic Adenocarcinoma of the Pancreas
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Gemcitabine, nab-Paclitaxel, GDC-0449
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PROmotion of COVID-19 BOOSTer VA(X)Ccination in the Emergency Department - PROBOOSTVAXED
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BEHAVIORAL: Vaccine Messaging|BEHAVIORAL: Vaccine Acceptance Question
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Study of Thoracic Aortic Aneurysm Exclusion
Status: UNKNOWN
Conditions: Thoracic Aortic Aneurysm
Interventions: DEVICE: Valiant Endoluminal Stent-Graft Stent-Graft Balloon Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telerehabilitation in Progressive Multiple Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Progressive Multiple Sclerosis
Interventions: DEVICE: Digital Telerehabilitation (Euleria Home)|OTHER: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Extension Study of LAQ/5062 Exploring the Long Term Safety, Tolerability and Clinical Effect Parameters During the Disease
Status: TERMINATED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: Laquinimod|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of 4.0 mg/kg Sugammadex at 1-2 Post Tetanic Counts (PTC) in Renal or Control Patients (19.4.328)(P05769)
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cisplatin or Carboplatin and Sorafenib in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Liver Cancer
Interventions: DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sublingual Misoprostol in Reduction of Caesarean Blood Loss
Status: RECRUITING
Conditions: Post Partum Hemorrhage
Interventions: DRUG: Misoprostol|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Novel Thoracic Wall Blocks With Dexmetomidine on Inflammatory Markers Following Breast Cancer Surgery
Status: UNKNOWN
Conditions: Inflammatory Markers
Interventions: PROCEDURE: Modified pectoralis block (PEC II) and pecto-intercostal fascial plane block (PIFB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SuperNO2VA™ and General Anesthesia Postoperative Care
Status: UNKNOWN
Conditions: Hypoxemia|Acute Respiratory Failure
Interventions: DEVICE: SuperNO2VA nasal positive airway pressure devic|DEVICE: Supplemental oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Temporo-Myofascial Disorder of Muscular Origin Using Botulinum Toxin: A Prospective Study
Status: UNKNOWN
Conditions: Temporo-Myofascial Disorder
Interventions: DRUG: Botulinum Toxin Type A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Multicenter, Open-label, Single Arm Clinical Study of Pomalidomide and dexamethasonE and Cyclophosphamide
Status: COMPLETED
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: DRUG: Imnovid (pomalidomide)|DRUG: Dexamethasone|DRUG: Endoxan (Cyclophosphamide)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Assessment of Oral Letermovir in Infants With Symptomatic Congenital Cytomegalovirus
Status: RECRUITING
Conditions: Congenital Cytomegalovirus Infection
Interventions: DRUG: Letermovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Response Based Treatment for Children With Unresectable Localized Soft Tissue Sarcoma
Status: UNKNOWN
Conditions: Unresectable Localized Soft Tissue Sarcoma
Interventions: DRUG: Cisplatin|DRUG: Etoposide|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Ifosfamide|DRUG: Carboplatin|RADIATION: Radiotherapy|DRUG: Thiotepa|DRUG: Melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Escalation Study of TPI 287 + Avastin Followed by Randomized Study of the Same Versus Avastin for Glioblastoma
Status: SUSPENDED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: TPI 287|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Long-term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis (CF) Particpants 6 Years and Older and F/MF Genotypes
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: ELX/TEZ/IVA|DRUG: IVA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cryotherapy and GM-CSF in Treating Patients With Lung Metastases or Primary Lung Cancer
Status: COMPLETED
Conditions: Kidney Cancer|Lung Cancer|Metastatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: sargramostim|OTHER: flow cytometry|OTHER: immunoenzyme technique|PROCEDURE: biopsy|PROCEDURE: cryosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential Use of Foley's Catheter and Misoprostol Versus Misoprostol Alone for Induction of Labour: a Multicentre Randomised Controlled Trial
Status: RECRUITING
Conditions: Induction of Labor
Interventions: COMBINATION_PRODUCT: Misoprostol 200mcg Tab|DRUG: Misoprostol 200mcg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3D Printed Silicone Coronary Artery Simulator for Percutaneous Coronary Interventional Training
Status: UNKNOWN
Conditions: Percutaneous Coronary Intervention
Interventions: OTHER: Training on coronary angiography using 3D coronary artery simulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Microbiotherapy in Characterized Depressive Disorder
Status: RECRUITING
Conditions: Depression|Depressive Disorder|Depressive Disorder, Major
Interventions: DIETARY_SUPPLEMENT: microbiotherapy (GynMDD)|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Double-Masked Trial of NOVA22007 (Ciclosporin 0.1%) Versus Vehicle in Patients With Moderate to Severe Dry Eye Syndrome
Status: COMPLETED
Conditions: Moderate to Severe Dry Eye Syndrome
Interventions: DRUG: NOVA22007 (Ciclosporin 0.1%)|DRUG: NOVA22007
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Favipiravir in Hospitalized COVID-19 Patients
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Favipiravir|DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biochemical and Physiological Response to Stressogenic Stimuli
Status: UNKNOWN
Conditions: Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: Stressogenic stimulus|DEVICE: Biobeat smart watch and adhesive biosensor patches.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study Estimating the Clinical Difference Between 300 mg and 150 mg of Secukinumab Following Dose Escalation to 300 mg in Patients With Ankylosing Spondylitis
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: DRUG: 150 mg open-label secukinumab|DRUG: 150 mg double-blinded secukinumab|DRUG: 300 mg double-blinded secukinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Necrotizing Enterocolitis of Premature Newborns Under Less Than 1500 g Using Probiotics
Status: COMPLETED
Conditions: Infectious Diseases
Interventions: DIETARY_SUPPLEMENT: use probiotics boucardii|DIETARY_SUPPLEMENT: use probiotics Multi-species
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Echinacea Versus Placebo Effect in Common Cold (Physician Echinacea Placebo)
Status: COMPLETED
Conditions: Common Cold
Interventions: DIETARY_SUPPLEMENT: Echinacea|OTHER: Blinded placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Temozolomide and Thalidomide in Treating Patients With Stage III or Stage IV Melanoma
Status: COMPLETED
Conditions: Intraocular Melanoma|Melanoma (Skin)
Interventions: DRUG: temozolomide|DRUG: thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Demonstrate Bioequivalence of Two 12.5 mg Empagliflozin/500 mg Metformin Fixed Dose Combination Tablets With Free Combination of Empagliflozin 25 mg and Metformin 1000 mg in Healthy Male and Female Volunteers Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Empagliflozin|DRUG: Metformin|DRUG: Empagliflozin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise Training Influences Gut Microbiota and Cardiovascular Health Through Inflammation Control in Adult Hypertensive Population: the MicroFit Study
Status: RECRUITING
Conditions: Hypertension|Microbiota
Interventions: BEHAVIORAL: exercise training|OTHER: Probiotics|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Propofol vs. Nasal Dexmedetomidine in Pediatric Agitation and Delirium
Status: COMPLETED
Conditions: Comparison of the Effects of Propofol and Nasal Dexmedetomidine
Interventions: DRUG: Dexmedetomidine|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Duration of Antibiotic Treatment of Erythema Migrans
Status: COMPLETED
Conditions: Erythema Chronicum Migrans
Interventions: DRUG: doxycycline|DRUG: doxycycline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pulp Revascularization Versus MTA Apexification
Status: COMPLETED
Conditions: Necrotic Pulp
Interventions: PROCEDURE: revascularization|PROCEDURE: Apexification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diamel in the Treatment of Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Diamel|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of the ForeCYTE Breast Aspirator for Cytological Testing of Nipple Aspirate Fluid in Women 30-55 Years Old
Status: WITHDRAWN
Conditions: Breast Cancer, Preneoplastic Conditions, BRCA
Interventions: DEVICE: ForeCYTE Breast Aspirator
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Checkpoint Inhibitors and SBRT for mCRPC
Status: RECRUITING
Conditions: Prostate Cancer Metastatic|Castrate Resistant Prostate Cancer|Metastatic Castration-resistant Prostate Cancer|Prostate Cancer Stage IV
Interventions: RADIATION: Stereotactic body radiotherapy|DRUG: Ipilimumab Injection [Yervoy]|DRUG: Nivolumab Injection [Opdivo]|PROCEDURE: Biopsies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Amino Acid L-arginine on Perioperative Cardio-vascular Risk in Non-selected Patients
Status: COMPLETED
Conditions: Cardiovascular Complication
Interventions: DIETARY_SUPPLEMENT: L-arginine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing the Combination of Selinexor-Daratumumab-Velcade-Dexamethasone (Dara-SVD) With the Usual Treatment (Dara-RVD) for High-Risk Newly Diagnosed Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Biopsy|DRUG: Bortezomib|PROCEDURE: Computed Tomography|BIOLOGICAL: Daratumumab|DRUG: Daratumumab and Recombinant Human Hyaluronidase|DRUG: Dexamethasone|DRUG: Lenalidomide|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aggravated Airway Inflammation: Research on Genomics and Optimal Operative Treatment (AirGOs Operative)
Status: ACTIVE_NOT_RECRUITING
Conditions: Sinusitis, Chronic|Asthma|Nasal Polyps|Aspirin Sensitivity
Interventions: PROCEDURE: Extended endoscopic sinus surgery|PROCEDURE: Limited endoscopic sinus surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Connectivity and Neural Signatures of Consciousness in Unresponsive States
Status: RECRUITING
Conditions: Acute Brain Injury|Traumatic Brain Injury|Consciousness Disorders|Seizures
Interventions: DEVICE: Intracranial electrodes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Multimodal Pain Management for Cesarean Delivery
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Intravenous acetominophen|DRUG: Ketorolac, intramuscular|DRUG: Bupivacaine, subcutaneous|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Vascular Ageing in the YOUth
Status: COMPLETED
Conditions: Atherosclerosis|Cardiovascular Risk Factor|Cardiovascular Diseases|Cardiovascular Pathology|Life Style|Vascular Diseases|Vascular Stiffness|Non-Alcoholic Fatty Liver Disease|Hypertension|Obesity|Overweight|Headache|Sleep|Sleep Disorder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Balance Training Protocols on Balance, Proprioception, ROM, and Pain in Athlete With Chronic Ankle Instability
Status: COMPLETED
Conditions: Chronic Ankle Instability
Interventions: OTHER: star excursion balance training (SEBT)|OTHER: Simplified star excursion balance training (SSEBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Focal Impulse and Rotor Modulation Ablation Trial for Treatment of Paroxysmal Atrial Fibrillation (FIRMAT-PAF)
Status: TERMINATED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: PROCEDURE: PVI Ablation|PROCEDURE: FIRM Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Foscarnet Versus Vidarabine in the Treatment of Herpes Infection in Patients With AIDS Who Have Not Had Success With Acyclovir
Status: COMPLETED
Conditions: Herpes Simplex|HIV Infections
Interventions: DRUG: Vidarabine|DRUG: Acyclovir|DRUG: Foscarnet sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study of ThermoDox With Approved Hyperthermia in Treatment of Breast Cancer Recurrence at the Chest Wall
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: ThermoDox in combination with Microwave Hyperthermia (heat)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Direct Laryngoscopic and Fiberoptic Intubation on Intraocular Pressure
Status: COMPLETED
Conditions: Intraocular Pressure|Intubation Complication
Interventions: OTHER: Direct laryngoscope|OTHER: Fiberoptic bronchoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of B1962, a PD-L1/VEGF Bispecific Antibody Fusion Protein, for Advanced Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Neoplasms Malignant
Interventions: DRUG: B1962
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Ultrasound Guided Caudal Block and Ultrasound Guided Pericapsular Nerve Group Block for Pediatric Hip Surgery
Status: COMPLETED
Conditions: Post Operative Pain After Pediatric Hip Surgery
Interventions: PROCEDURE: caudal block|PROCEDURE: pericapsular nerve group block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Swiss studY for the Treatment of COPD Patients With the Free combiNation of indacatERol and GlYcopyrroniumbromide.
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease: COPD
Interventions: DRUG: QAB149|DRUG: Placebo|DRUG: NVA237
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Typhoid Conjugate Vaccine Effectiveness in Ghana
Status: RECRUITING
Conditions: Typhoid Fever
Interventions: BIOLOGICAL: Vi-TT|BIOLOGICAL: MCV-A vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Ambrisentan With Antifibrotic Agent Combination Therapy in Diffuse Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis|Scleroderma
Interventions: DRUG: Ambrisentan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Delivery Timing Safety and Efficacy of AntiTachycardia Pacing (BIO|ATP)
Status: RECRUITING
Conditions: Implantable Cardioverter Defibrillator(ICD)
Interventions: DEVICE: 1:1 ratio for Treatment Group and Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuroprotective Effect of Butylphthalide for Cardiac Arrest Patients
Status: RECRUITING
Conditions: Butylphthalide|Cardiac Arrest|Neuroprotective Drugs
Interventions: DRUG: Butylphthalide and Sodium Chloride Injection|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First Line TIP in Poor Prognosis TGCTs.
Status: COMPLETED
Conditions: Germ Cell Tumor
Interventions: DRUG: Paclitaxel|DRUG: Ifosfamide|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ridaforolimus in Treating Patients With Recurrent Metastatic and/or Locally Advanced Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Cancer
Interventions: DRUG: ridaforolimus|GENETIC: gene expression analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Breakfast on Mental Workload
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DIETARY_SUPPLEMENT: Breakfast juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Retention for Hydrophilic and Hydrophobic Sealants in Uncooperative Children
Status: UNKNOWN
Conditions: Sound Newly Erupted First Permanent Molars With Deep Fissures Susceptible to Caries
Interventions: OTHER: Hydrophilic fissure sealant|OTHER: Hydrophobic fissure sealant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy And Safety of An IRE System For Treatment of Inferior Turbinate Hypertrophy
Status: RECRUITING
Conditions: Inferior Turbinate Hypertrophy|Nasal Obstruction|Turbinate; Hypertrophy Mucous Membrane
Interventions: DEVICE: IRE System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Polar Unite Fitness Watch to Improve Cognition for T2DM Patients
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2, Cognitive Dysfunction, Epigenetics, Exercise
Interventions: BEHAVIORAL: Aerobic exercise program|BEHAVIORAL: Stretching exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability, and Pharmacokinetics of AMG 827 in Adolescents With Asthma
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: AMG 827 or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE