pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Exploratory Platform Research on Precision Therapy of Advanced Pancreatic Cancer
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: SHR-A2102 or/and HRS-4642|DRUG: SHR-A1904 or/and HRS-4642|DRUG: SHR-A1811 or/and HRS-4642
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Market Study of the St. Jude Medical Angio-Seal™ V-Twist Integrated Platform (VIP) Vascular Closure Device
Status: COMPLETED
Conditions: Vascular Closure
Interventions: DEVICE: Angio-Seal VIP 6 French (6F) and 8 French (8F) devices
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase III Study for Patients With Metastatic Hormone-naïve Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Prostate Cancer
Interventions: DRUG: abiraterone acetate|RADIATION: radiotherapy|OTHER: Androgen Deprivation Therapy|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Bruxism Related Arousals on Cardiovascular Risk in Co-morbid Insomnia and Sleep Apnea
Status: ENROLLING_BY_INVITATION
Conditions: Sleep Apnea|Sleep Bruxism|Sleep Disorder|Insomnia|Comorbidities and Coexisting Conditions|Cardiovascular Diseases
Interventions: DIAGNOSTIC_TEST: Polysomnography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sex Hormone Supplementation and Rotator Cuff Repair: A Preliminary Randomized Trial
Status: RECRUITING
Conditions: Rotator Cuff Tears
Interventions: DRUG: Clomiphene Citrate|PROCEDURE: Rotator Cuff Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Mindfulness-Based Intervention in Patients With Cardiovascular Implantable Electronic Device
Status: ENROLLING_BY_INVITATION
Conditions: Mindfulness Training|Cardiac Resynchronization Therapy Devices|Resilience, Psychological|Anxiety|Depression|Perceived Stress
Interventions: BEHAVIORAL: mindfulness-based intervention|OTHER: CIED procedure routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: In-hospital Neutron Irradiator (IHNI)-Based Boron Neutron Capture Therapy (BNCT) in the Treatment of Malignant Melanoma
Status: UNKNOWN
Conditions: Melanoma|Boron Neutron Capture Therapy
Interventions: RADIATION: Boronophenylalanine and IHNI-based BNCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension Study up to 3 Years for Secukinumab in Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Secukinumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Rifaximin on Gut Microbiota and Emotion
Status: RECRUITING
Conditions: Healthy Volunteers|Stress|Fear
Interventions: DRUG: Rifaximin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess Impact of Dysport Injections Early After Stroke on Upper Limb Spasticity Progression
Status: COMPLETED
Conditions: Stroke|Upper Limb Spasticity
Interventions: BIOLOGICAL: Botulinum toxin type A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Walking Function in Diabetic Peripheral Neuropathy
Status: RECRUITING
Conditions: Diabetic Peripheral Neuropathy
Interventions: OTHER: Clinical Evaluation|OTHER: Evaluation of Passive Ankle Stiffness|OTHER: Gait Biomechanics|OTHER: Gait Biofeedback|OTHER: Plantar Pressure Biofeedback Gait Training|OTHER: Propulsion Biofeedback Gait Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Safety & Efficacy of Synbiotic on the Incidence and Recurrence of Spontaneous Bacterial Peritonitis (SBP) in Cirrhotics
Status: COMPLETED
Conditions: Cirrhosis With Ascites
Interventions: DRUG: Norfloxacin + Synbiotic|DRUG: Norfloxacin + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluate Analgesic Efficacy of Fast Release Aspirin
Status: COMPLETED
Conditions: Drugs, Investigational
Interventions: DRUG: Acetylsalicylic acid (Fast release Aspirin, BAY1019036)|DRUG: Acetylsalicylic Acid (Aspirin, BAYE4465)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Crossover Comparison of Two Gadolinium Contrast Agents for Use With MRA of Carotid, Renal and Peripheral Arteries
Status: COMPLETED
Conditions: Carotid, Aortic, Renal or Peripheral Artery Disease
Interventions: DRUG: Gadobenate Dimeglumine|DRUG: Gadopentetate Dimeglumine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Using Virtual Reality for Rehabilitation of Upper Limbs at Home Trial
Status: COMPLETED
Conditions: Upper Limb Injury|Virtual Reality|Rehabilitation|Paediatric
Interventions: DEVICE: Virtual Reality Upper Limb Motor Impairment Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: MTPr With Shockwave on Pain & Function of SHS in Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Myofascial trigger points pressure (MTrP) release|OTHER: Shockwave therapy application|OTHER: conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Epithelial Ovarian Cancer or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: amifostine trihydrate|DRUG: carboplatin|DRUG: cyclophosphamide|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Lyrica as Treatment for Sleep Problems in Patients With Sleep Problems and Seizures
Status: COMPLETED
Conditions: Sleep Deprivation|Epilepsies, Partial
Interventions: DRUG: Pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy
Status: RECRUITING
Conditions: Spastic Diplegia
Interventions: PROCEDURE: 3Tesla MRI with DTI-MRI and rsfcMRI under general anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial to Assess Effect of Raltegravir on HTLV-1 Proviral Load
Status: WITHDRAWN
Conditions: Human T-cell Leukemia Virus Type 1 Infection
Interventions: DRUG: Raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Study of SB1518 for the Treatment of Advanced Myeloid Malignancies
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Chronic Myelogenous Leukemia|Chronic Myelomonocytic Leukemia|Myelodysplastic Syndromes|Myelofibrosis
Interventions: DRUG: SB1518
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial).
Status: RECRUITING
Conditions: Liver Cirrhosis
Interventions: DRUG: Human albumin|DRUG: Enoxaparin|DRUG: Standard medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantitative D-dimer Level and Anticoagulant Therapy in Idiopathic Intracranial Hypertension
Status: COMPLETED
Conditions: Idiopathic Intracranial Hypertension
Interventions: DRUG: LMWH|DRUG: acetazolamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabetes Prevention Program Lifestyle Intervention in the Marshallese Population
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Wholeness, Oneness, Righteousness, Deliverance Diabetes Prevention Program|BEHAVIORAL: Partnership for Improving Lifestyle Intervention Diabetes Prevention Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety and Tolerability of Brexucabtagene Autoleucel (KTE-X19) in People With Relapsed/Refractory Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
Status: TERMINATED
Conditions: Relapsed/Refractory Chronic Lymphocytic Leukemia and Relapsed/Refractory Small Lymphocytic Lymphoma
Interventions: BIOLOGICAL: brexucabtagene autoleucel|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALS and Airway Clearance (ALSAC) Therapy
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis|Respiratory Muscle Weakness
Interventions: DEVICE: High Frequency Chest Wall Oscillation|DEVICE: Mechanical insufflation/exsufflation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sildenafil Study to Treat Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Alveolitis, Fibrosing|Fibrosis, Pulmonary|Hypertension, Pulmonary
Interventions: DRUG: sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Intravenous Biapenem (RPX2003) and RPX7009 Given Alone and in Combination
Status: COMPLETED
Conditions: Healthy Volunteers|Bacterial Infections
Interventions: DRUG: RPX7009|DRUG: Biapenem|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: E-Health for Zero Infections - Facilitating Access to and Use of HIV Pre-Exposure Prophylaxis (PrEP) in The Netherlands
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections
Interventions: OTHER: Variations in PrEP care delivery at public health services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Using Mobile Technology and Incentives With Men Who Have Sex With Men and Transgender Women for HIV Prevention
Status: COMPLETED
Conditions: HIV Infections|HIV
Interventions: BEHAVIORAL: Information provision|BEHAVIORAL: Weekly quizzes|BEHAVIORAL: Rewards for testing HIV-negative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Analgesic Efficacy of ESP Block and Caudal Block in Patients Undergoing Hypospadias Surgery
Status: COMPLETED
Conditions: Post Operative Pain|Hypospadias
Interventions: PROCEDURE: SACRAL ESP AND CAUDAL BLOCK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Predictors of Aortic Aneurysm Growth and Rupture
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: DRUG: Contrast Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Interest of Branched Chain Amino Acids Associated With a Respiratory Rehabilitation Program in Patients Broncho Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Broncho Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Amino Acids|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Energy Balance and Breast Cancer Aspects-II
Status: ACTIVE_NOT_RECRUITING
Conditions: DCIS Grade 3|Stage I Breast Cancer|Stage II Breast Cancer|LCIS, Lobular Carcinoma in Situ
Interventions: OTHER: Intervention. Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Zoledronic Acid as a Single Agent or as an Adjuvant to Chemotherapy in High Grade Osteosarcoma
Status: UNKNOWN
Conditions: Osteosarcoma
Interventions: DRUG: Zoledronic acid|DRUG: Standard chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apalutamide and Abiraterone Acetate in African American and Caucasian Men With Metastatic Castrate Resistant Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: ARN-509|DRUG: Abiraterone Acetate|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Three Dimensional Evaluation of Nasolabial Changes Following Classic vs Without Alar Base Suture After Le Fort I Osteotomy
Status: UNKNOWN
Conditions: Quality of Life
Interventions: OTHER: 3d evaluation of nasolabial change
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Early Amniotomy Versus Delayed Amniotomy Following Foley Catheter Ripening in Nulliparous Labor Induction
Status: COMPLETED
Conditions: Labor Induction
Interventions: PROCEDURE: Amniotomy|DEVICE: Foley Catheter|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Ametinib Combined With Bevacizumab in First-line Treatment of Advanced NSCLC With EGFR-mutations.
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Ametinib combined with bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: This Study in Healthy Men Tests How Different Doses of BI 894416 Are Taken up in the Body and How Well BI 894416 is Tolerated
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 894416|DRUG: Placebo|DRUG: BI 894416
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Effect of Vytorin (Simvastatin/Ezetimibe) 10/20mg Versus Atorvastatin 20mg on ApoB/ApoA1 Ratio in Subjects With Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus Without Insulin Treatment
Interventions: DRUG: simvastatin/ezetimibe|DRUG: atorvastatin 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glucose Control In Hematopoetic Stem Cell Transplant
Status: TERMINATED
Conditions: Hyperglycemia|Hematopoietic Stem Cell Transplantation
Interventions: DRUG: Regular Insulin|DEVICE: Deployment of the MiniMed Paradigm monitoring device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gut Microbial Metabolites Inosine Combined With PD-1/PD-L1 Inhibitor for Patients With Malignant Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumor
Interventions: DRUG: Inosine 0.2g orally 3 times/day|DRUG: PD-1/PD-L1 inhibitor ,chemotherapy/targeting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial of Mobile Technology for Adolescent Suicidality
Status: NOT_YET_RECRUITING
Conditions: Suicidal Ideation
Interventions: DEVICE: OTX-207|DEVICE: Comparator App + Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Fasting/Postprandial Serum Apolipoprotein B-48 (ApoB-48) Levels in Diabetic Participants With Normal to Moderately High Low Density Lipoprotein-C (LDL-C) Levels (MK-0653A-259 AM1)
Status: COMPLETED
Conditions: Dyslipidemia|Hypercholesterolemia
Interventions: OTHER: Test Meal
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Proof-of-Concept Study of Danicopan for 6 Months of Treatment in Participants With C3 Glomerulopathy (C3G)
Status: COMPLETED
Conditions: C3 Glomerulopathy|C3 Glomerulonephritis|Dense Deposit Disease
Interventions: DRUG: Danicopan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Assessment of an Anti-Cold Preparation in the Symptomatic Treatment of Common Cold and Flu-Like Syndrome
Status: UNKNOWN
Conditions: Common Cold|Flu-like Syndrome
Interventions: DRUG: Resfenol|DRUG: Placebo|DRUG: Co interventional acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rural Engagement in Primary Care for Optimizing Weight Reduction
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Fee-for-Service Model (FFS, In clinic individual visits)|BEHAVIORAL: Patient Centered Medical Home (PCMH, In clinic group visits)|BEHAVIORAL: Disease Management (DM, Phone group visits)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid Diagnostics for Upper Respiratory Infections in the Emergency Department
Status: COMPLETED
Conditions: Respiratory Tract Infections|Influenza, Human|Common Cold
Interventions: DEVICE: Rapid respiratory pathogen nucleic acid amplification test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pharmacological and Non-pharmacological Interventions in Management of Venipuncture Pain.
Status: COMPLETED
Conditions: Child, Hospitalized
Interventions: DRUG: EMLA application|BEHAVIORAL: Distraction techniques|OTHER: EMLA cream and distraction techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Self-Injury: Diagnosis and Treatment
Status: UNKNOWN
Conditions: Self-Injurious Behavior|Mental Retardation
Interventions: DRUG: Naltrexone hydrochloride|PROCEDURE: Transcutaneous sensory nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of SSS40 in Healthy Chinese Volunteers
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DRUG: SSS40|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation Of The Ability Of Fesoterodine To Increase Urethral Pressure In Stress Urinary Incontinence Patients
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: DRUG: Fesoterodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vital Pulp Therapy of Mature Permanent Teeth With Irreversible Pulpitis Using Bioceramic Material
Status: COMPLETED
Conditions: Vital Pulp Therapy
Interventions: OTHER: Apple vinegar or EDTA 17%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intervention and Mechanisms of Alanyl-Glutamine for Inflammation, Nutrition, and Enteropathy
Status: COMPLETED
Conditions: Malnutrition|Environmental Enteropathy|Diarrhea
Interventions: DIETARY_SUPPLEMENT: Alanyl-Glutamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Gliadel Followed by Avastin + Irinotecan for Glioblastoma Multiforme (GBM)
Status: TERMINATED
Conditions: Malignant Glioma|Glioblastoma Multiforme|Gliosarcoma
Interventions: DRUG: Gliadel/Avastin/CPT-11
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3MDR to Treat PTSD With mTBI (3MDR)
Status: UNKNOWN
Conditions: Posttraumatic Stress Disorder|Traumatic Brain Injury
Interventions: BEHAVIORAL: Motion-assisted, Multi-modular Memory Desensitization and Reconsolidation (3MDR) Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trans-incisional vs Laparoscopic Guided Rectus Sheath Block for Pediatric Single Incision Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: PROCEDURE: Trans-incisional rectus sheath block|PROCEDURE: Laparoscopic guided rectus sheath block|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Kinematic Biofeedback on Gait Quality in Stroke
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: OTHER: Gait training with biofeedback|OTHER: Gait training without biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study to Evaluate the Effects of Sequential Therapy With the Anti c-MET/VEGFR Tyrosine Kinase Inhibitor (TKI), Cabozantinib, Followed by an Anti-PD-1 Antibody (Nivolumab) in Patients With Advanced HCC Who Progressed on First-line Therapy
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma|Liver Cancer
Interventions: DRUG: Cabozantinib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Switching From a TDF-Containing Combination Regimen to a TAF-Containing Fixed Dose Combination (FDC) in Virologically-Suppressed, HIV-1 Positive Participants
Status: COMPLETED
Conditions: HIV|HIV Infections
Interventions: DRUG: E/C/F/TAF|DRUG: E/C/F/TDF|DRUG: EFV/FTC/TDF|DRUG: RTV|DRUG: ATV|DRUG: FTC/TDF|DRUG: COBI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arthroscopic-Assisted Reduction of Hip Dislocation Via Sub-Adductor and Anterolateral Portals
Status: COMPLETED
Conditions: Developmental Dysplasia of the Hip
Interventions: PROCEDURE: Arthroscopic-Assisted Reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Combination of Trastuzumab to Gemcitabine - Platinum Advanced or Metastatic Urothelial Carcinoma
Status: COMPLETED
Conditions: Recurrent Bladder Cancer|Stage IV Bladder Cancer|Transitional Cell Carcinoma of the Bladder
Interventions: BIOLOGICAL: Trastuzumab|DRUG: Gemcitabine|DRUG: Carboplatin|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Cellular Therapy for the Treatment of Pain Associated With Chronic Pancreatitis
Status: RECRUITING
Conditions: Chronic Pancreatitis|Chronic Pain
Interventions: DRUG: Mesenchymal stem cells|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MoviPrep® Versus GoLYTELY® Bowel Preparation in Hospitalized Patients Undergoing Colonoscopy
Status: RECRUITING
Conditions: Bowel Preparation Before Colonoscopy
Interventions: DRUG: MoviPrep|DRUG: Golytely
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Gut Microbiome on Cardiovascular Health Benefits of Dietary Lignans (CardioFlax Study).
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: lignan capsules contain 300 mg flaxseed (SDG) extract|DIETARY_SUPPLEMENT: Placebo treatment matching intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Perioperative Dexamethasone Administration on Postoperative Pain in Patients Undergoing Periacetabular Osteotomy.
Status: COMPLETED
Conditions: Dexamethasone|Hip Dysplasia|Postoperative Pain|Postoperative Nausea and Vomiting
Interventions: DRUG: Dexamethasone 24mg Solution for Injection|DRUG: Saline Solution for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Assess the Efficacy of Collagen Supplement in Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Collagen Supplement|OTHER: Glucosamine chondroitin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Patient-Partner Stress Management Effects on Chronic Fatigue Syndrome Symptoms and Neuroimmune Process
Status: COMPLETED
Conditions: Chronic Fatigue Syndrome
Interventions: BEHAVIORAL: Patient-Partner Videotelephone-delivered Health Information (PP-T-HI)|BEHAVIORAL: Patient-Partner Videotelephone-delivered Cognitive Behavioral Stress Management intervention (PP-T-CBSM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Cholinesterase Inhibitor Discontinuation
Status: COMPLETED
Conditions: Dementia
Interventions: DRUG: Cholinesterase inhibitor|DRUG: Sham discontinuation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrated Mindfulness-Based Cognitive Therapy for Singapore Malay Muslims
Status: COMPLETED
Conditions: Psychological Distress
Interventions: BEHAVIORAL: Mindfulness-based Cognitive Therapy|BEHAVIORAL: Counselling as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Correlation Between Psychological Intervention, Including Providing Knowledge and Tools for Problems Solving, and the Anxiety Level of Female Patients Arriving to ACTH LRH Test - Pilot Study
Status: TERMINATED
Conditions: Precocious Puberty
Interventions: BEHAVIORAL: Preliminary psychological intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Modern Myorelaxation Procedure and Reversal of Neuromuscular Blockade With General Anesthesia for Caesarean Section
Status: COMPLETED
Conditions: Caesarean Section|Pregnancy
Interventions: DRUG: Rocuronium + sugammadex|DRUG: Succinylcholine + Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Efficacy of GrafixPL for the Treatment of Venous Leg Ulcers
Status: COMPLETED
Conditions: Venous Leg Ulcer
Interventions: OTHER: GrafixPL|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of the Direct Interaction Between Streptococcus Salivarius 24SMBc and Streptococcus Oralis 89a and the Respiratory Epithelium in Children
Status: UNKNOWN
Conditions: Allergy
Interventions: COMBINATION_PRODUCT: Streptococcus salivarius 24SMBc + Strept. oralis 89a|COMBINATION_PRODUCT: fluticasone + mometasone|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cook´s Balloon Versus Dinoprostone for Labor Induction of Term Pregnancies With Fetal Growth Restriction
Status: RECRUITING
Conditions: Fetal Growth Retardation
Interventions: DEVICE: Cook´s balloon|DRUG: Vaginal dinoprostone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Investigate Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of BioChaperone® Pramlintide Insulin in Patients With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: BC Pram Ins|DRUG: Symlin® and Humulin®|DRUG: Humalog®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Mechanistic Effects of Mitapivat in Subjects With Sickle Cell Disease
Status: ENROLLING_BY_INVITATION
Conditions: Sickle Cell Anemia|Sickle Cell Thalassemia|Sickle Cell Pain|Hbss|Hbsc|Sickle Beta Thalassemia|Sickle Beta Zero Thalassemia|Sickle Cell Syndrome Variant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized Clinical Trial Comparing 4RIF vs. 9INH for LTBI Treatment-effectiveness
Status: COMPLETED
Conditions: Latent Tuberculosis Infection
Interventions: DRUG: Isoniazid|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, PK and Efficacy of AI-061 in Advanced Solid Tumors
Status: RECRUITING
Conditions: Melanoma|Non Small Cell Lung Cancer|Head and Neck Squamous Cell Carcinoma|High Grade Serous Adenocarcinoma of Ovary|Primary Peritoneal Carcinoma|Fallopian Tube Cancer|Endometrial Cancer|Cervical Cancer|Renal Cell Carcinoma|Bladder Cancer|Esophageal Cancer|Gastric Cancer|Gastroesophageal-junction Cancer|Colorectal Cancer|Anal Cancer|Hepatocellular Carcinoma|Bile Duct Cancer
Interventions: DRUG: AI-061
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin C in Atrial Fibrillation Ablation
Status: COMPLETED
Conditions: Atrial Fibrillation Ablation
Interventions: DRUG: Vitamin C|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Atezolizumab/Bevacizumab Followed by On-demand TACE or Initial Synchronous Treatment With TACE and Atezolizumab/Bevacizumab
Status: RECRUITING
Conditions: Hepatocellular Carcinoma Non-resectable
Interventions: COMBINATION_PRODUCT: Atezolizumab Injection, Bevacizumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Helping Urgent Care Users Cope With Distress About Physical Complaints
Status: COMPLETED
Conditions: Frequent Utilisers of Urgent Medical Care Who Have High Health Anxiety
Interventions: BEHAVIORAL: (Remote) Cognitive Behaviour Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine-Esketamine Combination for Sedation and Analgesia in ICU Patients
Status: NOT_YET_RECRUITING
Conditions: Aged|Intensive Care Units|Ventilators, Mechanical|Dexmedetomidine|Esketamine|Delirium
Interventions: DRUG: Dexmedetomidine-Esketamine Combination|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Synergistic Activity of Human Milk Nutrients and Infant Cognition
Status: RECRUITING
Conditions: Breastfeeding, Exclusive
Interventions: DIETARY_SUPPLEMENT: Whole Egg Powder|DIETARY_SUPPLEMENT: Egg White Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Single-dose Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of BMS-986263 in Participants With Varying Degrees of Liver Impairment
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: BMS-986263
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Rosuvastatin+Ezetimibe and Rosuvastatin for LDL-C Goal in Patients With Recent Ischemic Stroke
Status: UNKNOWN
Conditions: Stroke, Ischemic
Interventions: DRUG: Experimental: Rosuvastatin/Ezetimibe 10|DRUG: Active Comparator: Rosuvastatin 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ECGi Ibutilide: Effect of Ibutilide on AF Source Location and Organization
Status: TERMINATED
Conditions: Atrial Fibrillation|Persistent Atrial Fibrillation
Interventions: DEVICE: CardioInsight ECGI Mapping System|PROCEDURE: AF ablation|DRUG: Ibutilide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Assessment for Sotalol Protocol in Outpatient Unit
Status: UNKNOWN
Conditions: Supraventricular Arrhythmia|Ventricular Arrythmia|Proarrhythmia|Antiarrhythmic Drug Adverse Reaction
Interventions: DRUG: Sotalol Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Neoplasms|Carcinoma, Non-Small-Cell Lung
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Olaparib|DRUG: Placebo for olaparib|DRUG: Etoposide|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Paclitaxel|DRUG: Pemetrexed|RADIATION: Thoracic Radiotherapy|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of Genz-682452 in Healthy Men
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Genz-682452|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Selpercatinib Pre-RAI in Patients With RET Fusion Thyroid Cancer (RAISE)
Status: NOT_YET_RECRUITING
Conditions: Differentiated Thyroid Cancer|Pediatric Cancer|Cancer|Cancer, Thyroid
Interventions: DRUG: Selpercatinib Monotherapy|RADIATION: 131I Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Efficacy of Vatiquinone in Participants With Friedreich Ataxia
Status: ENROLLING_BY_INVITATION
Conditions: Friedreich Ataxia
Interventions: DRUG: Vatiquinone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "MILNACIPRAN" in Subjects With Chronic Shoulder Pain
Status: COMPLETED
Conditions: Chronic Shoulder Pain
Interventions: DRUG: milnacipran|DRUG: Milnacipran|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: MRI for Detecting Cancer in Women Who Are at High Risk of Developing Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: motexafin gadolinium|PROCEDURE: biopsy|PROCEDURE: breast imaging study|PROCEDURE: comparison of screening methods|PROCEDURE: magnetic resonance imaging|PROCEDURE: study of high risk factors
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SCREENING
Clinical trial: Brentuximab Vedotin in Pre-transplant Induction and Consolidation for Relapsed or Refractory Hodgkin Lymphoma
Status: COMPLETED
Conditions: CLASSICAL HODGKIN LYMPHOMA
Interventions: DRUG: Brentuximab Vedotin|DRUG: Etoposide|DRUG: Soludomerin|DRUG: Cisplatin|DRUG: Ara C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Vintafolide and Vintafolide Plus Paclitaxel Compared to Paclitaxel Alone in Participants With Triple Negative Breast Cancer (TNBC) (MK-8109-004)
Status: WITHDRAWN
Conditions: Breast Neoplasms
Interventions: DRUG: Vintafolide 2.5 mg|DRUG: Paclitaxel 80 mg/m^2|DRUG: Etarfolatide|DRUG: Folic acid|DRUG: Premedication for Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Paclitaxel-Eluting Percutaneous Transluminal Coronary Angioplasty (PTCA) - Balloon Catheter in Coronary Artery Disease to Treat Chronic Total Occlusions
Status: COMPLETED
Conditions: Coronary Artery Disease|Chronic Total Occlusion|Native Coronary Artery
Interventions: DEVICE: paclitaxel eluting PTCA balloon catheter (SeQuent Please)|DEVICE: paclitaxel eluting Taxus stent (Boston Scientific)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Donepezil (Aricept(Registered Trademark)) on REM Sleep in Children With Autism
Status: COMPLETED
Conditions: Autism|Cognition Disorder
Interventions: DRUG: Donepezil hydrochloride|BEHAVIORAL: Increase REM sleep percentage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Approach for Optimizing Meropenem Therapy in Intubated and Mechanically-Ventilated, Adult Patients With Severe Gram-Negative Lower Respiratory Tract Infection
Status: TERMINATED
Conditions: Lower Respiratory Tract Infection
Interventions: DEVICE: MON4STRAT Strategy|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOLCROM Trial: Foley Catheter in Rupture of Membranes
Status: COMPLETED
Conditions: Premature Rupture of Membranes
Interventions: DEVICE: Foley Catheter|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Traditional Chinese Medicine Xiang-sha-liu-jun Granules in Patients With Postprandial Distress Syndrome(PDS)
Status: UNKNOWN
Conditions: Postprandial Distress Syndrome
Interventions: DRUG: placebo|DRUG: Xiang-sha-liu-jun granules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of Two Fixed Dose Combination Tablets of Linagliptin/Pioglitazone Compared With Single Linagliptin and Pioglitazone Tablets Administered Together to Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Linagliptin/pioglitazone, FDC formulation C5|DRUG: Linagliptin/pioglitazone, FDC formulation C8|DRUG: Linagliptin tablet|DRUG: pioglitazone tablet (Actos®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CBP501 + Pemetrexed + Cisplatin on MPM (Phase I/II)
Status: COMPLETED
Conditions: Malignant Pleural Mesothelioma|Solid Tumors
Interventions: DRUG: pemetrexed, cisplatin and CBP501|DRUG: pemetrexed and cisplatin|DRUG: pemetrexed, cisplatin and CBP501, dose finding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Cultura Yoghurt in Relation to Transit Time and Digestive Discomfort in Healthy Women and Men
Status: COMPLETED
Conditions: Constipation
Interventions: OTHER: Cultura L casei F19, acidophilus La5 , B lactis Bb 12|OTHER: Yoghurt without probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Sucrose Ingestion During Exercise on Liver and Muscle Glycogen Concentration.
Status: COMPLETED
Conditions: Liver and Muscle Glycogen Use During Exercise.
Interventions: DIETARY_SUPPLEMENT: Glucose ingestion|DIETARY_SUPPLEMENT: Sucrose ingestion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pilot Study Evaluating the Toray Satake Balloon Thermal Ablation System for Treatment of Paroxysmal Atrial Fibrillation
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of NVC-422 in the Treatment of Adenoviral Conjunctivitis
Status: COMPLETED
Conditions: Adenoviral Conjunctivitis
Interventions: DRUG: NVC-422 Solution, 0.3%|DRUG: NVC-422 Vehicle Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Biomarker Study to Evaluate MN-166 (Ibudilast) in Subjects With Amyotrophic Literal Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: ibudilast
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluid Challenge and Plasma Volume, During Surgery
Status: RECRUITING
Conditions: Colorectal Cancer|Urologic Cancer|Gynecologic Cancer|Colorectal Disorders|Benign Neoplasm
Interventions: DRUG: acetated Ringers|DRUG: albumin 5%|DRUG: albumin 20%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection of Acetylsalicylic Acid and Omega-3 Fatty Acids in Schirmers' Test Strips Using Mass Spectrometry
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Aspirin 500Mg Tab|DIETARY_SUPPLEMENT: Dr. Böhm® Omega 3 complex 870 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Fit for Surgery. Multimodal Prehabilitation in Colorectal Cancer Patients
Status: UNKNOWN
Conditions: Colon Cancer|Rectal Cancer|Frailty
Interventions: OTHER: Prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Prebiotics on Blood Pressure Management
Status: NOT_YET_RECRUITING
Conditions: Hypertension|Gastrointestinal Microbiome
Interventions: DIETARY_SUPPLEMENT: Highland barley β-glucan dietary supplement|OTHER: Placebo controls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Fertility Health Awareness Strategies on Fertility Knowledge and Childbearing in Young Married Couples
Status: ACTIVE_NOT_RECRUITING
Conditions: Fertility Awareness|Childbearing Intentions
Interventions: DIAGNOSTIC_TEST: Fertility Health Screening|BEHAVIORAL: Fertility Awareness Tools
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neo-Adjuvant Abemaciclib With Fulvestrant in Patients With ER/PR +HER Negative Breast Cancer
Status: TERMINATED
Conditions: Breast Neoplasm|Hormone Receptor Positive Breast Carcinoma
Interventions: DRUG: Abemaciclib|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Avelumab and Hypofractionated Proton Radiation Therapy Followed by Surgery for Recurrent Radiation-refractory Meningioma
Status: TERMINATED
Conditions: Meningioma|Meningioma, Adult
Interventions: DRUG: Avelumab|RADIATION: Proton Therapy|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT