pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase II Study of RC48-ADC in Treating Patients With Salivary Gland Tumors Expressing HER2
Status: RECRUITING
Conditions: Salivary Gland Tumors
Interventions: DRUG: RC48-ADC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Trial of a Mobile Adherence Tool for Adolescents With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: Inhaler sensor|BEHAVIORAL: Mobile application for asthma adherence
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Magnesium Supplementation During General Anesthesia on the Quality of Postoperative Recovery in Children
Status: COMPLETED
Conditions: Emergence Delirium
Interventions: DRUG: Magnesium|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Temozolomide and Everolimus in Treating Patients With Stage IV Melanoma That Cannot be Removed by Surgery
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: DRUG: everolimus|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Therapeutic Effect Between Speech Rehabilitation Program and Speech Therapy in Stroke Patients With Aphasia
Status: RECRUITING
Conditions: Stroke|Aphasia|Speech Therapy
Interventions: DEVICE: Zenicog;language rehabilitation program|PROCEDURE: Conventional language rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Osteopathic Medical Manipulation to Decrease the Incidence and Severity of Post-Operative Sore Throat
Status: UNKNOWN
Conditions: Pharyngitis|Dysphonia
Interventions: PROCEDURE: Osteopathic Manipulation Treatment|PROCEDURE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Smoking Cessation Interventions in Stroke Patients
Status: UNKNOWN
Conditions: Ischemic Stroke
Interventions: BEHAVIORAL: Antismoking intervention with no early follow-up|BEHAVIORAL: Antismoking intervention with minimal early follow-up|BEHAVIORAL: Antismoking intervention with intensive early follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Accuracy of Combined Localization Versus Single Localization in Non-palpable Breast Cancer After Neoadjuvant Therapy
Status: RECRUITING
Conditions: Breast Cancer|Breast-conserving Surgery
Interventions: PROCEDURE: Wire-guided localization and marker clip localization|PROCEDURE: marker clip localization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Key Interventions to Improve the Follow-up Adherence Post Cervical Precancerous Lesion Treatment in Ethiopia: A Pragmatic RCT
Status: NOT_YET_RECRUITING
Conditions: Suspicious Cervical Cancer Lesions Follow up Adherence
Interventions: BEHAVIORAL: Intervention 1: Structured nurse-led telephone call reminders. Intervention 2: Home-visit reminders by health extension workers. Intervention 3: Application-based automated SMS text reminders.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Respiratory Disease Cohort Studies of Chinese Medicine for COPD(RESEARCH-COPD)
Status: NOT_YET_RECRUITING
Conditions: Chronic Obstructive Pulmoriary Disease (COPD)|Preserved Ratio Impaired Spirometry (PRISM)
Interventions: DRUG: traditional Chinese medicine (TCM)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Celebrex vs Tramadol in the Treatment of Chronic Lower Back Pain.
Status: COMPLETED
Conditions: Back Pain
Interventions: DRUG: Tramadol Hydrochloride 50mg|DRUG: Celebrex 200mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Enhancing a High School Based Smoking Cessation Program
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy|BEHAVIORAL: Contingency Management|DRUG: Nicotine Transdermal Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Levocetirizine Dihydrochloride Tablets 5 mg Under Fed Condition
Status: COMPLETED
Conditions: Fed
Interventions: DRUG: Levocetirizine Dihydrochloride tablets 5 mg|DRUG: Levocetirizine Dihydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictors of Ovarian Cancer and Endometrial Cancer for Artificial-Intelligence-Based Screening Tools
Status: RECRUITING
Conditions: Ovarian Cancer|Endometrial Cancer|Endometrial Hyperplasia
Interventions: DIAGNOSTIC_TEST: Artificial-Intelligence Based Screening Tools|DIAGNOSTIC_TEST: Pathology analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect on Blood Loss of Topical and Intravenous Tranexamic Acid in Cardiac Surgery Patients
Status: COMPLETED
Conditions: Blood Loss|Tranexamic Acid|Cardiac Surgery
Interventions: DRUG: 2 gr tranexamic acid|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Use of Bosentan in Patients With Exercise Induced Pulmonary Arterial Hypertension Associated With Connective Tissue Disease
Status: UNKNOWN
Conditions: Hypertension, Pulmonary|Connective Tissue Disease
Interventions: DRUG: bosentan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Videolaryngoscopes in Difficult Airway (SWIVITII)
Status: COMPLETED
Conditions: Difficult Intubation
Interventions: DEVICE: Airtraq, blade without channel for tracheal tube intubation|DEVICE: KingVision , blade without channel for tracheal tube intubation|DEVICE: A.P. Advance, blade without channel for tracheal tube intubation|DEVICE: Macintosh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Celtra Quatro Crown Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Fractured Tooth|Decayed Tooth|Unsatisfactory Restoration of Tooth
Interventions: DEVICE: Celtra Quatro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effects of Human Milk Oligosaccharide Ingestion on Weight Loss and Markers of Health
Status: COMPLETED
Conditions: Weight Loss
Interventions: DIETARY_SUPPLEMENT: 2'-Fucosyllactose|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bupropion Versus Escitalopram on Reward Circuitry and Motivational Deficits
Status: COMPLETED
Conditions: Major Depression
Interventions: DRUG: Bupropion XL|DRUG: Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quality of Life and Changes in Metabolism of Lipids and Glucose After Switching to a Nevirapine-based Regimen in HIV+ Patients
Status: COMPLETED
Conditions: HIV Infections|Quality of Life
Interventions: DRUG: Nevirapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Young Men's Health Project Targeting HIV Risk Reduction and Substance Abuse
Status: COMPLETED
Conditions: HIV Infections
Interventions: BEHAVIORAL: Clinic-based Delivery|BEHAVIORAL: Remote Delivery|BEHAVIORAL: Multi-modal Delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Distinguishing Bacterial and Viral Infections by MeMed BV® Test to Limit Gut Colonization by MDRO
Status: COMPLETED
Conditions: Viral Infection|Bacterial Infections|Multi-antibiotic Resistance|Respiratory Tract Infections
Interventions: DIAGNOSTIC_TEST: MeMed BV®
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Protein and Satiety in Older Adults (PROSAT)
Status: COMPLETED
Conditions: Appetitive Behavior|Gastric Emptying|Physical Activity|Energy Intake
Interventions: OTHER: High Protein Milkshake|OTHER: Normal Milkshake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study of PEGASYS (Peginterferon Alfa-2a) Plus Ribavirin in Patients With Chronic Hepatitis C (CHC), Genotype 2 or 3
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: peginterferon alfa-2a [Pegasys]|DRUG: peginterferon alfa-2a [Pegasys]|DRUG: ribavirin|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Brief Cognitive Intervention After Intrusive Memories of Trauma With Young Refugees: An Extension
Status: COMPLETED
Conditions: Intrusive Memories of Trauma, Symptom of Post Traumatic Stress Disorder (Criterion B1)
Interventions: BEHAVIORAL: Brief cognitive intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Reflectance Confocal Microscopy in Basal Cell Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Basal Cell
Interventions: DEVICE: Reflectance confocal microscopy|PROCEDURE: Punch biopsy|PROCEDURE: Surgical excision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Suprarenal Proximal Cuff Study for Treatment of Abdominal Aortic Aneurysm
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: DEVICE: Suprarenal Proximal Cuff Extension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection of EEG-Based Biomarkers of Chronic Low Back Pain
Status: RECRUITING
Conditions: Chronic Low-back Pain|Healthy
Interventions: BEHAVIORAL: Resting State EEG|BEHAVIORAL: Picture Viewing EEG|BEHAVIORAL: Stop Signal EEG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Contrast-Enhanced Ultrasound in Diagnosing Patients With Liver Cancer Undergoing Yttrium-90 Radioembolization
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Perflutren Lipid Microspheres|DRUG: Sulfur Hexafluoride Lipid Microspheres|DEVICE: Dynamic Contrast-Enhanced Ultrasound Imaging|DEVICE: Positron Emission Tomography|DEVICE: Computed Tomography|BIOLOGICAL: Yttrium-90 (90Y)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Telemedicine for Improved Delivery of Psychosocial Treatments for Post Traumatic Stress Disorder
Status: COMPLETED
Conditions: Posttraumatic Stress Disorders|Depression|Anxiety
Interventions: BEHAVIORAL: Prolonged exposure therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ex Vivo Cultured Adult Allogenic MSCs in Ischemic Cerebral Stroke
Status: WITHDRAWN
Conditions: Stroke
Interventions: BIOLOGICAL: Ex vivo cultured adult allogenic MSCs|OTHER: Plasmalyte-A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Defibrotide in COVID-19 Pneumonia
Status: COMPLETED
Conditions: Patients With COVID-19 Pneumonia Will Allow to Detect an Absolute Reduction in the Rate of Respiratory-failure
Interventions: DRUG: Defibrotide Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dobutamine Stress Echocardiography in LF/LG Aortic Stenosis and Wild-type Transthyretin Amyloid Cardiomyopathy
Status: RECRUITING
Conditions: Transthyretin Amyloid Cardiomyopathy|Aortic Stenosis
Interventions: DIAGNOSTIC_TEST: Dobutamine stress echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect Of Therapeutic Touch On Loneliness and Hopelessness
Status: COMPLETED
Conditions: Loneliness|Hope
Interventions: BEHAVIORAL: THERAPEUTİC TOUCH FOR HEMODİALYSİS PATİENTS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study in Relapsed and/or Refractory Multiple Myeloma Patients Treated With Ixazomib Plus Lenalidomide and Dexamethasone
Status: COMPLETED
Conditions: Relapsed and/or Refractory Multiple Myeloma
Interventions: DRUG: Ixazomib|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Metformin-FMD Trial
Status: COMPLETED
Conditions: Ischemia Reperfusion Injury|Endothelial Function
Interventions: DRUG: Metformin|DRUG: Pretreatment with metformin in combination of infusion of caffeine.|DRUG: No pretreatment with metformin in combination with infusion of caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BATAR: Individuals Currently Taking Boosted Atazanavir as Part of an HIV Treatment Regimen Will be Evaluated to See if Substituting Raltegravir for Nucleoside Transcriptase Inhibitors Will be Safe and Well Tolerated.
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: atazanavir/raltegravir|DRUG: atazanavir/raltegravir|DRUG: atazanavir/tenofovir/emtricitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improvement of Quality of Life Through Supportive Treatments for Hormone Therapy - Related Symptoms in Patients With Early Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: ER+ Breast Cancer|HER2-negative Breast Cancer|Breast Cancer Stage I|Breast Cancer Stage II|Breast Cancer Stage III|Drug-Related Side Effects and Adverse Reactions|Musculoskeletal Pain
Interventions: DRUG: Duloxetine 60 MG|DRUG: Furosemide 40 mg|BEHAVIORAL: Booklet for healthy behaviors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ESPB and ACB in Knee Arthroplasty
Status: COMPLETED
Conditions: Post Operative Pain
Interventions: PROCEDURE: Erector Spinae Plane Block|PROCEDURE: Adductor Canal Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeting Obesity With the Probiotic Lactiplantibacillus Plantarum IMC 510 (PRO-Weight-Control Study)
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Wholetones® 2Sleep Music on Health and Sleep Behaviors of Healthy Adults With Insomnia Symptoms
Status: COMPLETED
Conditions: Insomnia|Sleeplessness
Interventions: BEHAVIORAL: Wholetones Music|BEHAVIORAL: Classical Music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Guideline vs Usual Treatment in Schizophrenic Adolescents
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Guideline treatment (Risperidone, administered orally)|BEHAVIORAL: "Psychosocial treatment"|DRUG: Treatment as Usual (any other antipsychotic)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Chemotherapy Followed by Pulsed Docetaxel and Concurrent Radiation for Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: docetaxel|DRUG: cisplatin|PROCEDURE: radiation treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LEE011 With Everolimus in Patients With Advanced Neuroendocrine Tumors
Status: COMPLETED
Conditions: Neuroendocrine Tumors
Interventions: DRUG: LEE011|DRUG: everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between CAD/CAM and Conventional Mandibular Fixed Retainers.
Status: NOT_YET_RECRUITING
Conditions: Orthodontic Retainers
Interventions: DEVICE: CAD/CAM mandibular fixed retainer|DEVICE: Conventional mandibular fixed retainer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study Between Telmione 80 mg and Micardis 80 mg in Healthy Adult Volunteers
Status: UNKNOWN
Conditions: Hypertension
Interventions: DRUG: Telminone 80 mg|DRUG: Drug: Micardis 80 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Elderly Patients With Diffuse Large B-cell Lymphoma
Status: UNKNOWN
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: (R)-CHOP regimen|DRUG: (R)-CVP regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Sedentary Behavior vs. Increasing Physical Activity in Older Adults
Status: COMPLETED
Conditions: Sedentary Lifestyle
Interventions: OTHER: Reducing sedentary behavior group|OTHER: Moderate-to-vigorous activity group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Three Injections of EUFLEXXA (Sodium Hyaluronate) for Treatment of Chronic Shoulder Pain Associated With Osteoarthritis (OA)
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: EUFLEXXA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Orally-Administered Oseltamivir and Intravenous Zanamivir in Healthy Subjects
Status: WITHDRAWN
Conditions: Healthy Subjects
Interventions: DRUG: Oseltamivir and Intravenous Zanamivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Two Doses of GSK Biologicals' Live Attenuated HRV Vaccine (Two Different Formulations) in Healthy Infants.
Status: COMPLETED
Conditions: Infections, Rotavirus
Interventions: BIOLOGICAL: Human Rotavirus Vaccine - two different formulations|BIOLOGICAL: Prevnar|BIOLOGICAL: IPOL|BIOLOGICAL: Infanrix|BIOLOGICAL: OmniHIB|BIOLOGICAL: Pentacel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Pain Pen for Breakthrough Cancer Pain
Status: TERMINATED
Conditions: Neoplasms|Pain
Interventions: DRUG: Subcutaneous hydromorphone delivered by pain pen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Oxygen on Perioperative Outcome in Patients Undergoing General Anaesthesia for Elective Non-cardiac Surgery
Status: RECRUITING
Conditions: Coronary Artery Disease|Anesthesia
Interventions: DRUG: Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Different Mouthrinses in Plaque Formation
Status: UNKNOWN
Conditions: Dental Plaque
Interventions: DRUG: Chlorhexidine gluconate 0.12% (PerioGard®)|DRUG: Nanoparticle solution of M. alternifolia oil (0.3%).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Umbilical Cord Blood Transplant for Children With Myeloid Hematological Malignancies
Status: COMPLETED
Conditions: Myeloid Hematological Malignancies
Interventions: DRUG: Busulfan|DRUG: Cyclophosphamide|DRUG: Fludarabine|PROCEDURE: Cord Blood Stem Cell Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Recombinant Human Serum Albumin/Granulocyte Colony-Stimulating Factor Fusion Protein
Status: COMPLETED
Conditions: Chemotherapy-induced Neutropenia
Interventions: DRUG: HSA-GCSF 1.2 mg|DRUG: HSA-GCSF 1.5 mg|DRUG: GCSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Severe COVID-19 Infection in Children Presenting to EDs in Israel and England
Status: NOT_YET_RECRUITING
Conditions: COVID-19|Inflammatory Response
Interventions: DIAGNOSTIC_TEST: Nasopharyngeal swab sampling for COVID-19
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Investigational Treatments for COVID-19 in Tertiary Care Hospital of Pakistan
Status: COMPLETED
Conditions: Covid19|Cytokine Release Syndrome|Critical Illness|ARDS
Interventions: PROCEDURE: Therapeutic Plasma exchange|BIOLOGICAL: Convalescent Plasma|DRUG: Tocilizumab|DRUG: Remdesivir|BIOLOGICAL: Mesenchymal stem cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subthreshold Opioid Use Disorder Prevention (STOP) Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Opioid-use Disorder
Interventions: BEHAVIORAL: PCP brief advice|BEHAVIORAL: Video doctor|BEHAVIORAL: Telephone health coaching|BEHAVIORAL: Nurse Care Manager (NCM) intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Probiotics on Functional Constipation in the Elderly
Status: COMPLETED
Conditions: Functional Constipation
Interventions: DIETARY_SUPPLEMENT: Probalans senior|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Polyethylene Glycol Versus Lactulose on Hepatic Encephalopathy in Patients With Cirrhosis;(PEGHE Trial)
Status: RECRUITING
Conditions: Hepatic Encephalopathy
Interventions: DRUG: Polyethylene Glycols|DRUG: Lactulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Timolol 0.5% Solution for Proliferating Infantile Hemangiomas
Status: TERMINATED
Conditions: Hemangioma|Infant
Interventions: DRUG: topical 0.5% Timolol|DRUG: Control (placebo) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of HCP2102 in Essential Hypertension Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: HCP2102-1|DRUG: HPP2104-1|DRUG: HCP2102-2|DRUG: HPP2104-2|DRUG: RLD2106-1|DRUG: HPP2103-1|DRUG: RLD2106-2|DRUG: HPP2103-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of a New Antimicrobial Wound Dressing to Treat Wounds Caused by Curettage and Electrodesiccation
Status: COMPLETED
Conditions: Acute Wounds
Interventions: OTHER: Procellera™ Antimicrobial Dressing|OTHER: Mepilex® Border Lite|DEVICE: Adhesive Bandage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Nesiritide in Thoracic Aneurysm Repair to Prevent Acute Renal Failure
Status: UNKNOWN
Conditions: Cardiovascular Disease|Acute Renal Failure|Death
Interventions: DRUG: Nesiritide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Role of Negative Pressure Wound Therapy in Latissimus Dorsi Flap Donor Site Seroma Prevention
Status: COMPLETED
Conditions: NPWT|Latissimus Dorsi Flap|Breast Reconstruction
Interventions: DEVICE: The negative pressure wound therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: DREPAMASSE Study - Evaluation of a Newborn Screening for Sickle Cell Disease by Tandem Mass Spectrometry
Status: COMPLETED
Conditions: Sickle Cell Disease|Infant, Newborn, Disease|Drepanocytosis
Interventions: OTHER: SCD newborn screening with the MS/MS method from Zentech
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: IOP Lowering Efficacy of Travoprost/Brinzolamide Fixed Combination Ophthalmic Suspension in Patients With Open-Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Travoprost/brinzolamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Foscarnet in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS Who Have Not Had Success With Ganciclovir
Status: UNKNOWN
Conditions: Cytomegalovirus Retinitis|HIV Infections
Interventions: DRUG: Foscarnet sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Multiple Doses of BI 207127 NA, BI 201335 NA Followed by the Combination of BI 207127 NA and BI 201335 NA in Healthy Male Volunteers
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: BI 207127 NA|DRUG: BI 201335 NA|DRUG: Midazolam|DRUG: Tolbutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Norepinephrine Consumption After Prophylactic Ondansetron
Status: COMPLETED
Conditions: Maternal Hypotension
Interventions: DRUG: Ondansetron|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Retrospective Review of Gemcitabine, Methylprednisolone Cisplatin (GEM-P) With or Without Rituximab in Patients With Relapsed/Refractory Diffuse Large B Cell Lymphoma (DLBCL)
Status: COMPLETED
Conditions: Non-Hodgkins Lymphoma
Interventions: DRUG: Gemcitabine|DRUG: Cisplatinum|DRUG: Rituximab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Study of Apixaban for the Treatment of Deep Vein Thrombosis or Pulmonary Embolism
Status: COMPLETED
Conditions: Venous Thrombosis
Interventions: DRUG: Enoxaparin|DRUG: warfarin|DRUG: Placebo for apixaban|DRUG: Placebo for enoxaparin|DRUG: Placebo for warfarin|DRUG: apixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of a New Peripheral Oedema Monitor for Heart Failure
Status: COMPLETED
Conditions: Heart Failure, Diastolic|Edema Brain|Decompensated Heartfailure
Interventions: DEVICE: Heartfelt-1|DEVICE: Weighing scales|OTHER: Medical grading of oedema|OTHER: Baseline assessements|DEVICE: Water displacement method|DEVICE: Callipers measurements|DEVICE: Measuring tape
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluate the Safety and Immunogenicity of a 9-valent HPV Vaccine in Chinese Healthy Male Aged 9-45 Year-old
Status: COMPLETED
Conditions: Penile Cancer|Anal Cancer|PIN-1|PIN-2|PIN-3|AIN1|AIN2|AIN3|Genital Wart
Interventions: BIOLOGICAL: Placebo among 18-45 yrs|BIOLOGICAL: Placebo among 9-17 yrs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Vitrectomy Without Internal Limiting Membrane Removal in the Treatment of Diffuse Diabetic Macular Edema: a Comparative Kenalog Vs Bevacizumab Intravitreal Injection Vs Control Study
Status: WITHDRAWN
Conditions: Diffuse Diabetic Macular Edema
Interventions: DRUG: Triamcinolone Acetonide and Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bromocriptine-QR Therapy on Sympathetic Tone and Vascular Biology in Type 2 Diabetes Subjects
Status: COMPLETED
Conditions: Diabetic Autonomic Neuropathy
Interventions: DRUG: Cycloset|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lead-in Study to Collect Prospective Efficacy and Safety Data of Current FVIII Prophylaxis Replacement Therapy in Adult Hemophilia A Participants
Status: COMPLETED
Conditions: Blood Coagulation Disorder|Blood Coagulation Disorders, Inherited|Coagulation Protein Disorders|Hemophilia A|Genetic Diseases, Inborn|Genetic Diseases, X-Linked|Hematologic Diseases|Hemorrhagic Disorders|Factor VIII Deficiency
Interventions: DRUG: Standard of Care FVIII Replacement therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Subcutaneous Immunoglobulin Gammanorm on the Distribution of IgG Subclasses and on Immunity of Patients With Secondary Immunodeficiency
Status: COMPLETED
Conditions: Secondary Immune Deficiency
Interventions: DRUG: Gammanorm|DRUG: Other Subcutaneous Immunoglobulins
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Safety and Efficacy of Different Regimes of Reintroduction of Anti-TB Drugs in Anti-TB Drugs Induced Liver Damage
Status: COMPLETED
Conditions: Drug Induced Hepatotoxicity|Tuberculosis
Interventions: DRUG: Rifampicin(max dose 10 mg/kg/day), Isoniazide (max dose 5 mg/kg/day) and Pyrazinamide (max dose 25 mg/kg/day)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MK-5442 in the Treatment of Osteoporosis in Postmenopausal Women Previously Treated With an Oral Bisphosphonate (MK-5442-012)
Status: COMPLETED
Conditions: Osteoporosis|Postmenopausal Osteoporosis
Interventions: DRUG: MK-5442|DRUG: Placebo to MK-5442|DRUG: Alendronate Sodium|DRUG: Vitamin D3|DRUG: Calcium carbonate|DRUG: Placebo to Alendronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Oxaloacetate in Subjects With Treated PD
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Oxaloacetate (OAA)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neonatal Immunization With Pneumococcal Conjugate Vaccine in Papua New Guinea
Status: COMPLETED
Conditions: Pneumonia|Meningitis|Otitis Media
Interventions: BIOLOGICAL: Pneumococcal 7 valent conjugate vaccine (Prevenar®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bi-atrial Versus Left Atrial Ablation for Patients With Rheumatic Mitral Valve Disease and Non-paroxysmal Atrial Fibrillation
Status: RECRUITING
Conditions: Persistent Atrial Fibrillation
Interventions: PROCEDURE: Bi-atrial ablation|PROCEDURE: Left atrial ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rotigotine Versus Placebo to Evaluate the Efficacy on Depressive Symptoms in Idiopathic Parkinson's Disease Patients
Status: COMPLETED
Conditions: Idiopathic Parkinson's Disease
Interventions: DRUG: Rotigotine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of 68-GaNOTA-Anti-HER2 VHH1 Uptake in Brain Metastasis of Cancer Patients
Status: RECRUITING
Conditions: Carcinoma|Receptor, ErbB-2
Interventions: DRUG: 68GaNOTA-Anti-HER2 VHH1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Amitiza® Plus GoLYTELY® (PEG) Versus Placebo Plus GoLYTELY® for Outpatient Colonoscopy Preparation
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: lubiprostone (Amitiza)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sitravatinib With or Without Tislelizumab in Patients With Unresectable or Metastatic Melanoma
Status: UNKNOWN
Conditions: Melanoma
Interventions: DRUG: sitravatinib|DRUG: tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Beta-Blocker Therapy and Phosphodiesterase Inhibition on Cardiac Neurohormonal Activation
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Combined therapy with enoximone and esmolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Long-term Efficacy of Iguratimod Alone or Iguratimod in Combination With Methotrexate in Patients With Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Iguratimod|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot and Feasibility Trial of Plerixafor for Hematopoietic Stem Cell (HSC) Mobilization in Patients With Sickle Cell Disease Pilot and Feasibility Trial of Plerixafor for Hematopoietic Stem Cell (HSC) Mobilization in Patients With Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease Without Crisis
Interventions: DRUG: Plerixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Purpose of the Study is to Evaluate the Safety, Tolerability and Pharmacokinetics of Single-ascending and Multiple-ascending Doses of GIM-407
Status: NOT_YET_RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: GIM-407|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Itraconazole on the Pharmacokinetics of SHR6390 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: SHR6390 tablet|DRUG: Itraconazole capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Amoxicillin-Clavulanic Acid 400 Mg-57 mg Chewable Tablets Under Non-Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: amoxicillin-clavulanic acid|DRUG: Augmentin®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Sitagliptin and Metformin Hydrochloride Tablets 50 mg/500 mg Relative to Originator
Status: NOT_YET_RECRUITING
Conditions: Healthy Subjects
Interventions: DRUG: Sitagliptin and Metformin Hydrochloride Tablets 50 mg/500 mg Test product|DRUG: Sitagliptin and Metformin Hydrochloride Tablets 50 mg/500 mg Reference product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Growth Hormone Supplementation With Gonadotrophins in IVF/ICSI for Poor Responders
Status: COMPLETED
Conditions: Infertility, Female
Interventions: DRUG: Growth Hormones Somatropin Recombinant|DRUG: Placebo saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of AK104 in Subjects With Locally Advanced Unresectable or Metastatic MSI-H/dMMR Solid Tumors
Status: TERMINATED
Conditions: MSI-H/dMMR Solid Tumor
Interventions: DRUG: AK104
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effects of Tasimelteon vs. Placebo on Jet Lag Type Insomnia
Status: COMPLETED
Conditions: Jet Lag Type Insomnia
Interventions: DRUG: Tasimelteon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: T-Regulatory Cell and CD3 Depleted Double Umbilical Cord Blood Transplantation in Hematologic Malignancies
Status: WITHDRAWN
Conditions: Hematologic Malignancy|Acute Myeloid Leukemia|Acute Lymphocytic Leukemia|Chronic Myelogenous Leukemia in Blast Crisis|Anemia, Refractory, With Excess of Blasts|Chronic Myeloproliferative Disease|Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|Marginal Zone B-cell Lymphoma|Follicular Lymphoma|Lymphoplasmacytic Lymphoma|Mantle-Cell Lymphoma|Prolymphocytic Lymphoma|Large Cell Non-Hodgkin's Lymphoma|Lymphoblastic Lymphoma|Burkitt's Lymphoma|High Grade Non-Hodgkin's Lymphoma
Interventions: BIOLOGICAL: Treg cells|BIOLOGICAL: CD3+ Teff cells|DRUG: Fludarabine|DRUG: Cyclophosphamide|RADIATION: Total body irradiation|BIOLOGICAL: Umbilical cord blood transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Astragalus Membranaceus for Brain Edema Induced by Hemorrhagic Stroke
Status: COMPLETED
Conditions: Stroke|Hemorrhagic Transformation Due to Acute Stroke
Interventions: DRUG: Chinese Herb Astragalus membranaceus|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of the Effect of Intravitreal Dexamethasone Injection on Diabetic Macular Edema After Cataract Surgery (IDDMECS)
Status: COMPLETED
Conditions: Diabetes|Macular Edema|Pseudophakia
Interventions: DRUG: Dexamethasone sodium phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial of Autologous, Hapten-Modified Vaccine, OVAX, in Patients With Relapsed Stage III or IV Ovarian Cancer
Status: UNKNOWN
Conditions: Adenocarcinoma of the Ovary
Interventions: BIOLOGICAL: OVax: Autologous, DNP-Modified Ovarian Cancer Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality to Teach, Improve Outcomes, and Engage (VIRTUE): Virtual Reality to Improve Gluten-Free Diet Knowledge in Pediatric Celiac Disease
Status: NOT_YET_RECRUITING
Conditions: Celiac Disease in Children
Interventions: DEVICE: Virtual Reality Goggles to provide education a regarding the gluten free diet.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating Efficacy and Safety of Oxaliplatin With 5-Fluorouracil in Patients With Recurrent Ovarian Carcinoma
Status: COMPLETED
Conditions: Ovarian Carcinoma|Relapse
Interventions: DRUG: Oxaliplatin|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Test the Efficacy of Periarticular Levo Bupivicaine Injection Following Primary Hip Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Levobupivacaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Advanced Soft Tissue Sarcoma|Locally Advanced Angiosarcoma|Locally Advanced Leiomyosarcoma|Locally Advanced Liposarcoma|Locally Advanced Malignant Peripheral Nerve Sheath Tumor|Locally Advanced Myxofibrosarcoma|Locally Advanced Undifferentiated Pleomorphic Sarcoma|Metastatic Angiosarcoma|Metastatic Epithelioid Sarcoma|Metastatic Fibrosarcoma|Metastatic Liposarcoma|Metastatic Malignant Peripheral Nerve Sheath Tumor|Metastatic Myxofibrosarcoma|Metastatic Soft Tissue Sarcoma|Metastatic Synovial Sarcoma|Metastatic Undifferentiated Pleomorphic Sarcoma|Myxofibrosarcoma|Pleomorphic Rhabdomyosarcoma|Stage III Soft Tissue Sarcoma AJCC v7|Stage IV Soft Tissue Sarcoma AJCC v7|Undifferentiated (Embryonal) Sarcoma|Unresectable Leiomyosarcoma|Unresectable Liposarcoma|Unresectable Malignant Peripheral Nerve Sheath Tumor|Unresectable Soft Tissue Sarcoma|Unresectable Synovial Sarcoma|Unresectable Undifferentiated Pleomorphic Sarcoma
Interventions: DRUG: Doxorubicin Hydrochloride|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Ribociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continued Access Clinical Trial of the SonRtip Lead and Automatic AV-VV Optimization Algorithm in the PARADYM RF SonR CRT-D
Status: UNKNOWN
Conditions: Heart Failure (NYHA Class III and Ambulatory IV)
Interventions: DEVICE: SonR automatic optimization feature turned ON ("AV+VV").
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dysport in Post-Surgical Neuralgia
Status: COMPLETED
Conditions: Chronic Scar Pain
Interventions: DRUG: Lidocaine|BIOLOGICAL: Botulinum toxin type A|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Daily Zinc Supplement Effect on Prevention of Diarrhea and Acute Respiratory Infections in Children Less Than Five Years
Status: COMPLETED
Conditions: Zinc Deficiency|Child Nutrition Disorders
Interventions: DIETARY_SUPPLEMENT: zinc|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Dipeptidyl Peptidase-4 Inhibition and Narrow-band Ultraviolet-B Light in Psoriasis (DINUP)
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Sitagliptin (Januvia)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EUropean Real-world Experience Of Previously Treated Advanced/Metastatic HER2-positive Breast Cancer Patients Accessing Trastuzumab Deruxtecan
Status: COMPLETED
Conditions: HER2-positive Breast Cancer
Interventions: DRUG: Trastuzumab deruxtecan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence Study of Torrent Pharmaceutical Ltd.'s Olanzapine Orally Disintegrating 5mg Tablets Under Fed Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Olanzapine Orally Disintegrating 5mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: A Dose-finding Study of CC-90009 in Subjects With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher-risk Myelodysplastic Syndromes
Status: TERMINATED
Conditions: Leukemia, Myeloid, Acute|Myelodysplastic Syndromes
Interventions: DRUG: CC-90009
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Grazoprevir (MK-5172) + Elbasvir (MK-8742) With or Without Ribavirin for Participants With Hepatitis C Genotype 1, 4, or 6 Infections Who Have Failed Prior Treatment With Pegylated Interferon + Ribavirin (MK-5172-068)
Status: COMPLETED
Conditions: Hepatitis C Infection
Interventions: DRUG: Grazoprevir + Elbasvir|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iron Fortified Food to Improve Japanese Encephalitis and Typhoid Fever Vaccine Immunogenicity
Status: RECRUITING
Conditions: Iron Deficiency Anemia
Interventions: OTHER: Iron-fortified cookies|BIOLOGICAL: Japanese encephalitis (JE) vaccine|BIOLOGICAL: Typhoid Vi polysaccharide (Vi-PS) vaccine|OTHER: non-fortified cookies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION