pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Assess Subcutaneous AK002 in Eosinophilic Gastritis and/or Eosinophilic Duodenitis
Status: WITHDRAWN
Conditions: Eosinophilic Gastritis|Eosinophilic Duodenitis
Interventions: DRUG: AK002|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Mild Hypobaric Hypoxia on Sleep and Post-sleep Performance
Status: COMPLETED
Conditions: Altitude|Hypoxia|Environmental Sleep Disorder
Interventions: PROCEDURE: altitude exposure in hypobaric chamber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Health-circuit Evaluation as a Digital Support for the Management of Patients at Risk of Hospitalization
Status: COMPLETED
Conditions: Multiple Chronic Conditions|Chronic Disease
Interventions: BEHAVIORAL: Health-Circuit mobile application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Investigate the Efficacy and Safety of Brepocitinib in Adults With Dermatomyositis
Status: ACTIVE_NOT_RECRUITING
Conditions: Dermatomyositis
Interventions: DRUG: Brepocitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing MB02 and Avastin® in Subjects With Stage IIIB/IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: MB02 (Bevacizumab Biosimilar Drug)|DRUG: EU-approved Avastin®|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: INCB18424 in Treating Young Patients With Relapsed or Refractory Solid Tumor, Leukemia, or Myeloproliferative Disease
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: ruxolitinib phosphate|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Pharmacokinetics of Sulfasalazine, Paracetamol, Fexofenadine and Valsartan Using Different Administration Mediums
Status: COMPLETED
Conditions: Pharmacokinetics|Magnetic Resonance Imaging|Administration, Oral
Interventions: DRUG: Paracetamol|DRUG: Sulfasalazine|DRUG: Fexofenadine|DRUG: Valsartan|DEVICE: non-caloric water|DEVICE: caloric drink|DEVICE: grapefruit juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: IDA-01 A Randomised, Open-Label, Comparative Study of Intravenous Iron Isomaltoside 1000 (Monofer®) and Iron Sucrose
Status: COMPLETED
Conditions: Iron Deficiency Anaemia
Interventions: DRUG: iron isomaltoside 1000 (Monofer®)|DRUG: iron sucrose (Venofer®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Saroglitazar Magnesium 4 mg in the Treatment of NAFLD in Women With PCOS (EVIDENCES VII)
Status: RECRUITING
Conditions: Non-alcoholic Fatty Liver Disease in Women With PCOS
Interventions: DRUG: Saroglitazar Magnesium 4 mg Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy(Immunogenicity) of GC3114 in Healthy Adults
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: GC3114|BIOLOGICAL: GCFLU Quadrivalent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Fibrinolysis Before Cardiopulmonary Bypass?
Status: COMPLETED
Conditions: Pathologic Fibrinolysis
Interventions: DRUG: Epsilonaminocaproic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: nVNS for the Prevention and Treatment of Primary Headache
Status: NOT_YET_RECRUITING
Conditions: Primary Headache|Migraine in Adolescence|Migraine in Children|Cluster Headache|Tension Headache
Interventions: DEVICE: Transcutaneous auricular vagus nerve stimulation|DEVICE: Sham transcutaneous auricular vagus nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pozelimab and Cemdisiran Combination Therapy in Patients With Sporadic Inclusion Body Myositis
Status: NOT_YET_RECRUITING
Conditions: Sporadic Inclusion Body Myositis (sIBM)|Idiopathic Inflammatory Myopathies
Interventions: COMBINATION_PRODUCT: Pozelimab/Cemdisiran
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Innate Immune Responses in Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Multi-electrode Circular Irreversible Electroporation (IRE) Catheter and Multi-Channel IRE Generator in Paroxysmal Atrial Fibrillation (AF)
Status: ACTIVE_NOT_RECRUITING
Conditions: Refractory Paroxysmal Atrial Fibrillation
Interventions: DEVICE: Multi-Channel Irreversible Electroporation (IRE) Generator|DEVICE: Multi-Channel Circular IRE Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy With Combination Immunotherapy for Relapsed/Refractory Metastatic Melanoma
Status: WITHDRAWN
Conditions: Metastatic Melanoma|Pulmonary Metastases|Hepatic Metastases|Brain Metastases
Interventions: DRUG: Interleukin-2 & Ipilimumab (P-Ib)|DRUG: Interleukin-2 & Ipilimumab (P-II)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Bioequivalence Study: Pre-filled Syringe (Reference) Versus Auto-injection Device (Test)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Certolizumab pegol|DRUG: Certolizumab pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Validation of the New Print on Focus DAILIES Toric
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: nelfilcon A contact lens, modified inversion indicator|DEVICE: nelfilcon A contact lens, no inversion indicator|DEVICE: nelfilcon A contact lens, inversion indicator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ecteinascidin 743 in Treating Children With Refractory Solid Tumors
Status: COMPLETED
Conditions: Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: ECTEINASCIDIN 743
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Controlled Human Infection for Vaccination Against Streptococcus Pyogenes
Status: COMPLETED
Conditions: Streptococcus Pyogenes Pharyngitis|Streptococcus Pharyngitis|Strep Throat|Streptococcus Pyogenes Infection|Group A Streptococcus: B Hemolytic Pharyngitis|Group A Streptococcal Infection|Gram-Positive Bacterial Infections|Bacterial Infections
Interventions: BIOLOGICAL: emm75 Streptococcus pyogenes (GAS M75, strain 611024)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Open Thoracic Paravertebral Block on Postoperative Analgesia
Status: COMPLETED
Conditions: Lung Cancer
Interventions: COMBINATION_PRODUCT: Open TPVB|COMBINATION_PRODUCT: Ultrasound-guided TPVB|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: CoQ10 and Omega-3 as Adjuncts to Periodontal Therapy, TAC of Saliva.
Status: ENROLLING_BY_INVITATION
Conditions: Periodontal Diseases
Interventions: DRUG: Receive 30 mg of Coq10|DRUG: Non-Medicare Drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neurolens Convergence Insufficiency Study
Status: TERMINATED
Conditions: Binocular Vision Disorder|Convergence Insufficiency|Computer Vision Syndrome
Interventions: DEVICE: Neurolens spectacle lens|DEVICE: Placebo spectacle lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Lubiprostone on Gastrointestinal Transit & pH in Irritable Bowel Syndrome (IBS) With Constipation
Status: COMPLETED
Conditions: Irritable Bowel Syndrome|Constipation
Interventions: DRUG: Lubiprostone|DRUG: Placebo|OTHER: Smartpill wireless motility capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Real-world Evaluation of Bezlotoxumab for the Management of Clostridioides Difficile Infection
Status: COMPLETED
Conditions: Clostridium Difficile Infection|Clostridium Difficile Infection Recurrence
Interventions: BIOLOGICAL: Bezlotoxumab|DRUG: Standard CDI treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Role of Vaginal Misoprostol Prior to IUCD Insertion in Women Who Delivered Only by Elective Caesarean Section.
Status: UNKNOWN
Conditions: IUD Insertion Complication
Interventions: DRUG: misoprostol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Acupuncture on Blood Pressure and Heart Rate Variability (HRV)
Status: UNKNOWN
Conditions: Hypertension
Interventions: DEVICE: acupuncture|DEVICE: sham needle treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality for the Management of Pain and Anxiety for Outpatient Interventional Radiology Procedures
Status: COMPLETED
Conditions: Pain|Anxiety
Interventions: DEVICE: Virtual Reality|PROCEDURE: Standard Procedure Thyroid Biopsy|PROCEDURE: Standard Procedure PICC Placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dry Eye Assessment and Management Study
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Omega-3 supplements|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proportion of CMV Seropositive Kidney Transplant Recipients Who Will Develop a CMV Infection When Treated With an Immunosuppressive Regimen Including Everolimus and Reduced Dose of Cyclosporine Versus an Immunosuppressive Regimen With Mycophenolic Acid and Standard Dose of Cyclosporine A
Status: COMPLETED
Conditions: Transplantation Infection|Cytomegalovirus Infection
Interventions: DRUG: Everolimus|DRUG: mycophenolic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total Robotic Versus Robotic Assisted Distal Gastrectomy for Gastric Cancer
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer|Robotic Gastrectomy
Interventions: PROCEDURE: Total Robotic Distal Gastrectomy|PROCEDURE: Robotic-Assisted Distal Gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ERCP Plus Laparoscopic Cholecystectomy Versus Laparoscopic Common Bile Duct Exploration and Cholecystectomy
Status: COMPLETED
Conditions: Common Bile Duct Calculi
Interventions: PROCEDURE: Endoscopic retrograde cholangiopancreatography plus laparoscopic cholecystectomy|PROCEDURE: aparoscopic common bile duct exploration and laparoscopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Eerder Erbij: The Path Towards Offering Timely Support for People With Dementia and Their Caregivers
Status: RECRUITING
Conditions: Dementia, Mild
Interventions: OTHER: Eerder Erbij
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: S0120, Studying Blood and Bone Marrow Samples From Patients With Monoclonal Gammopathy of Undetermined Significance, Multiple Myeloma, or Plasmacytoma
Status: COMPLETED
Conditions: Multiple Myeloma|Plasma Cell Myeloma|Precancerous Condition
Interventions: GENETIC: cytogenetic analysis|GENETIC: microarray analysis|OTHER: biologic sample preservation procedure|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: INvestigating TELmisartin Study
Status: TERMINATED
Conditions: Covid19
Interventions: DRUG: Telmisartan Oral Product|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Pressure Ulcers Prevention With Mepilex® Border Sacrum Dressing in Scheduled Cardiovascular Surgery
Status: UNKNOWN
Conditions: Pressure Ulcers|Prevention|Skin Ulcer|Ulcer
Interventions: COMBINATION_PRODUCT: Mepilex® Border dressing|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Total Antioxidant Effects of Esomeprazole in Dyspeptic Patients Receiving Non-steroidal Anti-inflammatory Drugs
Status: WITHDRAWN
Conditions: Dyspepsia
Interventions: DRUG: Esomeprazole Magnesium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relapse Prevention in Stimulant Use Disorder
Status: WITHDRAWN
Conditions: Stimulant Use|Relapse|Cognitive Function|ADHD
Interventions: DRUG: Contrave 8Mg-90Mg Extended-Release Tablet|DRUG: Bupropion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multiparametric MRI in Healthy Volunteers and CKD Patients
Status: RECRUITING
Conditions: Chronic Kidney Diseases|Healthy
Interventions: DIAGNOSTIC_TEST: Non- contrast Enhanced Multiparametric Renal Magnetic Resonance
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy & Safety Study of YH22162 vs Telmisartan/Amlodipine in Patients With Hypertension Inappropriately Controlled on Telmisartan/Amlodipine Treatment
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: telmisartan/amlodipine 40/5mg|DRUG: YH22162 40/5/12.5 mg|DRUG: telmisartan/amlodipine 80/5mg|DRUG: YH22162 80/5/25 mg|DRUG: telmisartan/amlodipine 40/5mg placebo|DRUG: YH22162 40/5/12.5 mg placebo|DRUG: telmisartan/amlodipine 80/5mg placebo|DRUG: YH22162 80/5/25 mg placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of the Combination of Tirabrutinib and Idelalisib With and Without Obinutuzumab in Adults With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Tirabrutinib|DRUG: Idelalisib|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of PTI-808, PTI-801, and PTI-428 Combination Therapy in Subjects With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: PTI-808|DRUG: Placebo|DRUG: PTI-801|DRUG: PTI-428|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Spironolactone in Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DRUG: Spironolactone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continuing Lamivudine Versus Switching to Entecavir in Patients Who Achieved Undetectable Hepatitis B Virus DNA
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Entecavir|DRUG: Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualized Response Assessment to Heated Intraperitoneal Chemotherapy (HIPEC) for the Treatment of Peritoneal Carcinomatosis From Ovarian, Colorectal, Appendiceal, or Peritoneal Mesothelioma Histologies
Status: RECRUITING
Conditions: Peritoneal Carcinomatosis|Peritoneal Mesothelioma|Ovarian Cancer|Gastrointestinal Cancer|Appendiceal Cancer
Interventions: DRUG: Mitomycin C|DRUG: Cisplatin|PROCEDURE: Heated Intraperitonial Chemotherapy|DRUG: Doxorubicin|DRUG: Oxaliplatin|DRUG: 5-Fluorouracil|DRUG: Sodium Thiosulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Trial of HRS-9813 in Healthy Volunteers
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: HRS-9813|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carefully seLected and Easily Accessible at No Charge Medications
Status: UNKNOWN
Conditions: Medication Adherence|Inappropriate Prescribing|Diabetes|Hypertension
Interventions: OTHER: Free and convenient medicine access
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Distal Radius Fracture - Treatment Comparison
Status: TERMINATED
Conditions: Minimally Displaced Intra-articular Distal Radius Fracture
Interventions: DEVICE: Surgical Treatment|DEVICE: Non surgical Treatment (Cast or splint)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing Yield of Confocal Endomicroscopy Guided Biopsies
Status: TERMINATED
Conditions: Barrett's Esophagus
Interventions: OTHER: Fluorescence-aided confocal endomicroscopy guided biopsy.|OTHER: Random four-quadrant biopsies.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ketorolac for Moderate to Severe Abdominal Pain in Children
Status: COMPLETED
Conditions: Abdominal Pain|Appendicitis|Analgesia|Child, Only|Emergencies
Interventions: DRUG: Ketorolac Tromethamine 10 MG/ML|DRUG: Morphine Sulfate 10Mg/1mL Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Functional Outcomes of Tourniquet Use in Primary Total Knee Arthroplasty
Status: NOT_YET_RECRUITING
Conditions: Total Knee Arthroplasty
Interventions: PROCEDURE: total knee arthroplasty(TKA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Pilot Trial of Interferon Beta-1a in Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Interferon beta-1a|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Subcutaneously Administered Interleukin-12 Therapy in HIV-Infected Patients With Disseminated Mycobacterium Avium Complex Infection
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome|Mycobacterium Avium-Intracellulare Infection
Interventions: DRUG: Interleukin-12
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Implementation and Testing of an eHealth Integrated Model of Care for Patients Receiving Allogeneic Stem Cell Transplantation: The SMILe Project
Status: ACTIVE_NOT_RECRUITING
Conditions: Stem Cell Transplantation
Interventions: DEVICE: SMILe-Integrated Care Model|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Major De-escalation to 30 Gy for Select Human Papillomavirus Associated Oropharyngeal Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: HPV-Associated Oropharyngeal Squamous Cell Carcinoma|Squamous Cell Carcinoma of the Neck
Interventions: DIAGNOSTIC_TEST: F-FMISO PET/CT Scan|RADIATION: 30 Gy over 3 weeks|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: 5Fluorouracil|RADIATION: Proton Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Inhaled Budesonide-formoterol-glycopyrronium in Moderate-to-severe COPD
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: BGF Inhalation Aerosphere|DRUG: GFF Inhalation Aerosphere
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Using the Medpulser Electroporation System With Bleomycin to Treat Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: COMBINATION_PRODUCT: Medpulser Electroporation with Bleomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PACAP38´s (Pituitary Adenylate Cyclase-Activating Polypeptide) Headache Inducing Characteristics and Effects on the Cerebral Blood Flow
Status: COMPLETED
Conditions: Migraine Without Aura
Interventions: DRUG: PACAP38
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Efficacy Comparison of 2 Low-dose Atropine Eye Drops in Vietnamese Children Myopia Management
Status: NOT_YET_RECRUITING
Conditions: Myopia
Interventions: DRUG: Myatro|DRUG: Myatro XL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT:Oropharyngeal Leak Pressure (OLP) - Ambu AuraGain vs LMA Supreme
Status: COMPLETED
Conditions: Laryngeal Masks
Interventions: DEVICE: Ambu AuraGain|DEVICE: LMA Supreme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Electric Blower Based Ventilator Used During Procedural Sedation
Status: COMPLETED
Conditions: Apnea During Procedural Sedation
Interventions: DEVICE: Noninvasive Ventilator (V60, Philips)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Effectiveness of Artemisinin-based Combination Therapies (ACTs) With Repeated Treatments for Uncomplicated Falciparum Malaria Over a Three-year Period
Status: UNKNOWN
Conditions: Malaria
Interventions: DRUG: Artemether-lumefantrine combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Usability of the SB11 PFS in Subjects With Wet AMD or Macular Oedema Secondary to RVO
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration|Macular Edema|Retinal Vein Occlusion
Interventions: COMBINATION_PRODUCT: SB11 PFS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide and Azathioprine vs Tacrolimus in Antisynthetase Syndrome-related Interstitial Lung Disease
Status: UNKNOWN
Conditions: Antisynthetase Syndrome (ASS)|Interstitial Lung Disease
Interventions: DRUG: Cyclophosphamide and azathioprine|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fatigue in People With Rheumatoid Arthritis- Randomized Controlled Trial
Status: COMPLETED
Conditions: Fatigue|Rheumatoid Arthritis
Interventions: BEHAVIORAL: Person-centered physical therapy intervention program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Liver Stiffness With Shear Wave Elastography
Status: COMPLETED
Conditions: Chronic Liver Disease|Advanced Fibrosis|Advanced Cirrhosis
Interventions: DEVICE: Endoscopic Ultrasound Shear Wave Elastography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Ramucirumab or Icrucumab (IMC-18F1) With Docetaxel or Docetaxel Alone as Second-Line Therapy in Participants With Bladder,Urethra, Ureter, or Renal Pelvis Carcinoma
Status: COMPLETED
Conditions: Carcinoma of Urinary Tract|Urethral Carcinoma|Carcinoma of Ureter|Carcinoma of Renal Pelvis
Interventions: DRUG: Docetaxel|BIOLOGICAL: Ramucirumab DP|BIOLOGICAL: Icrucumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating Maintenance Olaparib in Patients With Platinum-sensitive Advanced Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Olaparib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of ICA-105665 Using the Intradermal Capsaicin and Ultraviolet B (UV-B) Models in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ICA-105665|DRUG: Ibuprofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Non-inferiority Evaluation of Multicenter, Randomized, Single-blind, Parallel-controlled Clinical Trials on the Safety and Efficacy of Full-suture Anchors for Rotator Cuff Injury and/or Shoulder Instability Surgery
Status: UNKNOWN
Conditions: Shoulder Instability Rotator Cuff Injury
Interventions: DEVICE: Total arthroscopic rotator cuff repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Short-term Sequential Therapy in Non-complicated Catheter Related Bacteremia by Methicillin- Susceptible S.Aureus.
Status: TERMINATED
Conditions: Staphylococcus
Interventions: DRUG: Cloxacilin|DRUG: Cloxacillin|DRUG: Levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of GSK1278863 in Japanese Non-dialysis (ND) and Peritoneal Dialysis (PD) Subjects With Renal Anemia
Status: COMPLETED
Conditions: Anaemia
Interventions: DRUG: 1 to 4 mg tablets of GSK1278863|DRUG: 6 mg GSK1278863 tablet|DRUG: Epoetin beta pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melatonin Effects on Sleep and Circadian Rhythm in Youth and Young Adults With At-risk Symptoms
Status: COMPLETED
Conditions: Psychosis|Sleep
Interventions: DRUG: oral melatonin tablets (NatureMade brand)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of the Pathogenesis and Pathophysiology of Familial Neurohypophyseal Diabetes Insipidus
Status: COMPLETED
Conditions: Diabetes Insipidus|Diabetes Insipidus, Neurohypophyseal
Interventions: DRUG: chlorpropamide|DRUG: desmopressin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Durvalumab, an Anti-PDLI Antibody, and Tremelimumab, an Anti-CTLA4 Antibody, and Chemoradiation Before Surgery for Esophageal Cancer
Status: RECRUITING
Conditions: Esophageal Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma
Interventions: BIOLOGICAL: durvalumab|DRUG: carboplatin AUC 2/paclitaxel|RADIATION: External beam radiation (EBRT)|PROCEDURE: esophagogastrectomy|DRUG: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Effects of Apnoeic Oxygenation With High-flow Nasal Oxygen in Adults Undergoing Laryngeal Surgery - a Randomised Study
Status: RECRUITING
Conditions: Laryngeal Disease
Interventions: DEVICE: Apnoeic oxygenation with high-flow nasal oxygen|OTHER: Mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ticagrelor-based De-escalation of Dual Antiplatelet Therapy After Coronary Artery Bypass Grafting
Status: RECRUITING
Conditions: Coronary Artery Disease|Coronary Artery Bypass Grafting|Dual Antiplatelet Therapy|Bleeding|Myocardial Infarction|Myocardial Ischemia|Angina Pectoris
Interventions: DRUG: De-escalated Dual Antiplatelet Therapy|DRUG: Dual Antiplatelet Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transfusion Surveillance in Anaesthesia
Status: RECRUITING
Conditions: Transfusion Reaction|Transfusion Related Complication|Anesthesia|Anesthesia; Shock|Side Effect|Fresh Blood Stool|Blood Coagulation Disorder|Blood Loss
Interventions: PROCEDURE: Transfusion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Acceptability of I-GEL® in Pediatric Patients: Comparison of Clinical Performance With Classic-LMA™
Status: COMPLETED
Conditions: Endotracheal Intubation
Interventions: DEVICE: i-gel airway (Intersurgical Ltd., Wokingham, England)|DEVICE: Laryngeal Mask Airway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Pimasertib With SAR245409 or Placebo in Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Pimasertib once daily|DRUG: Pimasertib placebo|DRUG: SAR245409 placebo|DRUG: SAR245409|DRUG: Pimasertib twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled Interferon α2b Treatment in Mild-to-moderate COVID-19 Infected Children
Status: TERMINATED
Conditions: COVID-19|Children
Interventions: DRUG: Inhaled Interferon α2b|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Combination of ATRA and Danazol as Second-line Treatment in Adult Immune Thrombocytopenia
Status: COMPLETED
Conditions: Autoimmune Thrombocytopenia
Interventions: DRUG: All-trans retinoic acid|DRUG: Danazol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Study of STP938 for Adult Subjects With Relapsed/Refractory B-Cell and T-Cell Lymphomas
Status: RECRUITING
Conditions: Lymphoma, B-Cell|Lymphoma, T-Cell
Interventions: DRUG: STP938
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib With Capecitabine and Oxaliplatin for Advanced or Metastatic Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Advanced Hepatocellular Carcinoma|Metastatic Hepatocellular Carcinoma
Interventions: DRUG: Sorafenib with Capecitabine and Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Ascending Single-Dose Study of the Safety, Tolerability and Bioeffect of REGN1193
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: REGN1193|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of the Ipsilateral Nipple as the Directional Guide for Internal Jugular Vein (IJV) Catheterization
Status: COMPLETED
Conditions: Ipsilateral Nipple|Internal Jugular Vein|Catheterization
Interventions: PROCEDURE: SCM triangle - ipsilateral nipple
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Biopsy- and Biology-driven Optimization of Targeted Therapy in Subjects With Advanced Melanoma
Status: TERMINATED
Conditions: Malignant Melanoma
Interventions: DRUG: Dabrafenib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management Tactics for Patients High Risk With Acute Coronary Syndrome Without ST Segment Elevation and Multivessel Coronary Artery Disease
Status: RECRUITING
Conditions: Coronary Syndrome, Acute, Non-ST Elevation, High Risk Patients
Interventions: PROCEDURE: Revascularization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Norketotifen in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Norketotifen Oral Capsule (Cohort 1)|DRUG: Norketotifen Oral Capsule (Cohort 2)|DRUG: Norketotifen Oral Capsule (Cohort 3)|DRUG: Norketotifen Oral Capsule (Multiple Dose Cohort)|DRUG: Placebo Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Caffeine Supplementation on Specific Performance and Training Activities
Status: COMPLETED
Conditions: Supplementation|Sports
Interventions: DIETARY_SUPPLEMENT: Caffeine supplementation|DIETARY_SUPPLEMENT: Placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of 2 Options for Second Line Combination Antiretroviral Therapy Following Virological Failure of a Standard Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI)+2N(t)RTI First Line Regimen
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: raltegravir|DRUG: 2N(t)RTI|DRUG: Ritonavir-boosted lopinavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enzalutamide, Radiation Therapy and Hormone Therapy in Treating Patients With Intermediate or High-Risk Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Adenocarcinoma of the Prostate|Recurrent Prostate Cancer|Stage IIB Prostate Cancer|Stage III Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: Enzalutamide|DRUG: Goserelin acetate|DRUG: Leuprolide acetate|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Multiple Immunotherapy-Based Treatment Combinations in Hormone Receptor (HR)-Positive Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Neoplasms
Interventions: DRUG: Atezolizumab (MPDL3280A), an engineered anti-programmed death-ligand 1 (PD-L1) antibody|DRUG: Bevacizumab|DRUG: Entinostat|DRUG: Exemestane|DRUG: Fulvestrant|DRUG: Ipatasertib|DRUG: Tamoxifen|DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tipifarnib and Naxitamab for Relapsed/Refractory Neuroblastoma
Status: NOT_YET_RECRUITING
Conditions: Neuroblastoma Recurrent
Interventions: DRUG: Tipifarnib|DRUG: Naxitamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrapartum Glycemic Control With Insulin Infusion Versus Rotating Fluids
Status: ACTIVE_NOT_RECRUITING
Conditions: Type II Diabetes Mellitus|Gestational Diabetes Mellitus
Interventions: OTHER: Rotating fluids protocol|OTHER: Insulin infusion protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Antioxidant Therapy in Lean and Obese Asthmatics
Status: COMPLETED
Conditions: Asthma
Interventions: DIETARY_SUPPLEMENT: Vitamins A, E, C & Selenium|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Contact Aspiration Versus Stent Retriever for Recanalisation of Acute Stroke Patients With Basilar Artery Occlusion: The Posterior Circulation ASTER Randomized Trial Protocol
Status: RECRUITING
Conditions: Basilar Artery Occlusion
Interventions: PROCEDURE: Contact aspiration Thrombectomy|PROCEDURE: Stent retriever thrombectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retrospective TIF Study for Treatment of Gastroesophageal Reflux Disease (GERD). The RetroTIF Study
Status: TERMINATED
Conditions: Gastroesophageal Reflux Disease (GERD)
Interventions: DEVICE: Transoral Incisionless Fundoplication
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TAS102 in Combination With NAL-IRI in Advanced GI Cancers
Status: RECRUITING
Conditions: Colorectal Adenocarcinoma|Gastric Adenocarcinoma|Metastatic Pancreatic Adenocarcinoma|Non-Resectable Cholangiocarcinoma|Stage IV Colorectal Cancer|Stage IV Gastric Cancer|Stage IV Pancreatic Cancer|Stage IVA Colorectal Cancer|Stage IVB Colorectal Cancer|Stage III Colorectal Cancer|Stage III Gastric Cancer|Stage III Pancreatic Cancer|Unresectable Digestive System Adenocarcinoma|Unresectable Pancreatic Carcinoma
Interventions: DRUG: Nanoliposomal Irinotecan|DRUG: Trifluridine and Tipiracil Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study to Evaluate the Effectiveness of Dexmedetomidine in Preventing Delirium After Heart Surgery
Status: WITHDRAWN
Conditions: Delirium
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: the Efficacy and Safety of Oliceridine Fumarate Injection for Acute Pain After Abdominal Surgery
Status: NOT_YET_RECRUITING
Conditions: Acute Pain|Opioid Analgesic Adverse Reaction
Interventions: DRUG: Oliceridine Injection [Olinvyk]|DRUG: Sufentanil Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Sovateltide (PMZ-1620) in Patients of Acute Ischemic Stroke
Status: COMPLETED
Conditions: Cerebral Ischemia|Cerebral Infarction|Stroke, Acute
Interventions: DRUG: Normal Saline along with standard treatment|DRUG: PMZ-1620 (sovateltide) along with standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa
Status: TERMINATED
Conditions: Intermittent Preventive Treatment In Pregnancy (IPTp)
Interventions: DRUG: Azithromycin plus chloroquine|DRUG: sulfadoxine-pyrimethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Alpha Lipoic Acid Supplementation in G6PD Deficient Individuals After Acute Exercise
Status: COMPLETED
Conditions: G6PD Deficiency
Interventions: DIETARY_SUPPLEMENT: Alpha-lipoic acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screening for Pneumonia: A Comparison of Ultra Low Dose Chest CT [ULD-CT] and Conventional Chest Radiography [CXR]
Status: UNKNOWN
Conditions: Pneumonia
Interventions: RADIATION: ULD-CT|RADIATION: CXR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ReActivate: Physiotherapist Led Intervention for Adolescents With Pain and Psychological Distress.
Status: RECRUITING
Conditions: Chronic Pain|Emotional Distress
Interventions: BEHAVIORAL: Reactivate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Diagnostic Value of Acupoint Sensitization Based on Stable Angina Pectoris
Status: COMPLETED
Conditions: Stable Angina Pectoris|Acupoint Sensitization|Correlation Analysis|Diagnostic Value
Interventions: COMBINATION_PRODUCT: Coronary angiography,Canadian Cardiovascular Society angina pectoris classification for the severity of angina and electronic Von Frey instrument for testing the degree of acupoint sensitization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Anti-epileptic Drugs on Etonogestrel-releasing Implant Pharmacokinetics in Women With Epilepsy
Status: UNKNOWN
Conditions: Contraception|Drug Interactions
Interventions: DRUG: Carbamazepine-Implant|DRUG: Topiramate-Implant|DRUG: Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Safety and Pharmacology of Subcutaneous Administration of CINRYZE With Recombinant Human Hyaluronidase
Status: COMPLETED
Conditions: Hereditary Angioedema
Interventions: BIOLOGICAL: CINRYZE with rHuPH20
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Single Dose Study of N1539 in the Treatment of Pain Secondary to Dental Impaction Surgery
Status: COMPLETED
Conditions: Dental Pain
Interventions: DRUG: N1539|DRUG: placebo|DRUG: N1539|DRUG: N1539|DRUG: Motrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of a Novel Stress Testing Protocol to Define the Relationship Between Coronary Microvascular Dysfunction and Diastology in Women With Angina But No Evidence of Obstructive Coronary Artery Disease
Status: RECRUITING
Conditions: Microvascular Coronary Dysfunction
Interventions: OTHER: Handgrip|OTHER: Altitude simulation|OTHER: Leg exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Relative Bioavailability Study of Griseofulvin 125 mg/5 mL Suspension Under Non-fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Griseofulvin 125 mg/5 mL Suspension, single dose|DRUG: Grifulvin V® 125 mg/5 mL Suspension, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Effects of Propofol and Sevoflurane on Blood Folic Acid and Homocysteine Concentrations in Children
Status: UNKNOWN
Conditions: Sevoflurane|Propofol|Homocysteine|Cochlear Hearing Loss
Interventions: DRUG: Sevoflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER