pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Food Effects on Milademetan Pharmacokinetics in Healthy Participants
Status: COMPLETED
Conditions: Food Effects on Pharmacokinetics
Interventions: DRUG: Milademetan Treatment A|DRUG: Milademetan Treatment B|DRUG: Milademetan Treatment C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influence of Trabeculectomy and Phaco-trabeculectomy on Corneal Astigmatism
Status: UNKNOWN
Conditions: Astigmatism|Glaucoma
Interventions: DEVICE: Biometry|DEVICE: Refraction|DEVICE: Corneal Topography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Examining Effect for Dextroamphetamine to Treat Cocaine Dependence Plus Attention-deficit Hyperactivity Disorder (ADHD)
Status: TERMINATED
Conditions: Attention Deficit Disorder With Hyperactivity|Cocaine-Related Disorders|Substance-Related Disorders
Interventions: DRUG: Placebo|DRUG: Dextroamphetamine SR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Novel Coding Strategies for Children With Cochlear Implants
Status: RECRUITING
Conditions: Deafness
Interventions: OTHER: Single-Electrode Pulse Train|OTHER: Modulation Detection Threshold (MDT) and Gap Detection Tasks|OTHER: Sound coding strategy.|OTHER: Electric-only spectral resolution
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Chronic Total Occlusion Crossing With the Ocelot System - CONNECT II
Status: COMPLETED
Conditions: Total Atherosclerotic Occlusion of Femoral Artery
Interventions: DEVICE: CTO crossing in femoropopliteal arteries CONNECT II
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3D Printing Guides in Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Osteoarthritis of the Knee
Interventions: DEVICE: 3D-Printed Patient-Specific Intramedullary Guide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Coronary Angioplasty in Octogenarians With Emergent Coronary Syndromes
Status: UNKNOWN
Conditions: Non-ST Elevation Myocardial Infarction (NSTEMI)|Angina, Unstable
Interventions: PROCEDURE: Coronary angiography and revascularization if feasible
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Electronic Shared Decision-Making Application to Improve Asthma Outcomes
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Electronic Asthma Shared Decision-Making App|BEHAVIORAL: Shared Decision Making Physician Training Video|BEHAVIORAL: Electronic Asthma Shared Decision-Making App- Patient Data|BEHAVIORAL: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Transcutaneous Perineal Stimulation Versus Anal Stimulation
Status: COMPLETED
Conditions: Urinary Incontinence|Radical Prostatectomy|Pelvic Floor
Interventions: OTHER: Transcutaneous perineal stimulation|OTHER: Anal stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Internet Cognitive Behavioral Therapy for Insomnia to Prevent Cardiovascular Disease
Status: TERMINATED
Conditions: Insomnia Chronic|Subclinical Disease and/or Syndrome
Interventions: BEHAVIORAL: Internet-delivered Cognitive Behavioral Therapy for Insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Rivaroxaban in the Management of Acute Non-neoplastic PVT Compensated Cirrhosis
Status: UNKNOWN
Conditions: Portal Vein Thrombosis
Interventions: DRUG: rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictive Value of Serum and Tissue Molecular Markers and Imaging Features in the Invasiveness and Prognosis of Pituitary Neuroendocrine Tumors
Status: RECRUITING
Conditions: Pituitary Adenoma|Neuroendocrine Tumors
Interventions: OTHER: diagnosed and treated reasonably according to the clinical guidelines and clinical pathways
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects Upon the Bladder of Transcutaneous Tibial Nerve Stimulation in Acute Traumatic Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury|Neurogenic Bladder
Interventions: DEVICE: Transcutaneous Tibial Nerve Stimulation|DEVICE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparing Fluid Responsiveness Assessment Methods in Patients With Impaired Consciousness
Status: RECRUITING
Conditions: Hypotension|Cognitive Impairment
Interventions: DIAGNOSTIC_TEST: Inferior vena cava's diameter ratio|DIAGNOSTIC_TEST: Central venous pressure|DIAGNOSTIC_TEST: Passive leg raising test|DIAGNOSTIC_TEST: Fluid challenge|PROCEDURE: Fluid infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nonsurgical Periodontal Therapy on Banded First Molars
Status: COMPLETED
Conditions: Periodontitis
Interventions: PROCEDURE: Full-mouth supragingival scaling|PROCEDURE: Subgingival scaling|DRUG: Subgingival irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: HIV-1 Infected Adult Subjects With HIV-associated Neurocognitive Disorders Despite Effective Antiretroviral Therapy
Status: COMPLETED
Conditions: HIV-1-infection|HIV Associated Neurocognitive Disorder
Interventions: OTHER: Validation of Charter score for the CNS diffusion of antiretroviral drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients
Status: COMPLETED
Conditions: Tracheal Stenosis
Interventions: DRUG: Prednisolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Study of Danicopan in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)
Status: COMPLETED
Conditions: Paroxysmal Nocturnal Hemoglobinuria (PNH)
Interventions: DRUG: Danicopan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Safety and Acceptability of an Investigational Injectable Product, TMC278LA, for Pre-Exposure Prophylaxis
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV)
Interventions: DRUG: Rilpivirine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Low Power Laser in Tooth Pain Modulation Caused by Irreversible Inflammation
Status: COMPLETED
Conditions: Pulpitis|Acute Pain
Interventions: OTHER: No additional Intervention (control)|RADIATION: Sham Laser Irradiation|RADIATION: Laser 1 (at 0,16 Joules/point of irradiation)|RADIATION: Laser 2 (1,6 Joules/point of irradiation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: A Phase I Study of 5-Azacytidine in Combination With Chemotherapy for Children With Relapsed or Refractory ALL or AML
Status: COMPLETED
Conditions: Lymphoblastic Leukemia, Acute, Childhood|Myelogenous Leukemia, Acute, Childhood
Interventions: DRUG: Azacytidine|DRUG: Fludarabine|DRUG: Cytarabine|DRUG: Intrathecal (IT) Cytarabine|DRUG: Intrathecal Methotrexate (IT MTX)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides
Status: COMPLETED
Conditions: Pneumonia, Pneumocystis Carinii|HIV Infections
Interventions: DRUG: Atovaquone|DRUG: Dapsone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: F01 in the Treatment of Relapsed/Refractory Non-hodgkin's Lymphoma
Status: RECRUITING
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: After preconditioning with chemotherapy, F01 will be evaluated.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation in Treatment of Binge Eating Disorder
Status: UNKNOWN
Conditions: Binge-Eating Disorder
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effect of Age and Injury Severity on Short-term Intra-hospital Outcomes After Surgical Stabilized Rib Fractures
Status: RECRUITING
Conditions: Rib Fractures|Rib Trauma|Rib Fracture Multiple|Thorax; Fracture
Interventions: PROCEDURE: Surgical stabilisation of rib fractures (SSRF)|OTHER: Non-operative management of rib fractures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Study of Targeting CD7 CAR-T Cells in the Treatment of Autoimmune Diseases
Status: RECRUITING
Conditions: Crohn Disease|Ulcerative Colitis|Dermatomyositis|Still Disease|Autoimmune Diseases
Interventions: BIOLOGICAL: CD7 CAR T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate a Range of Dose Levels of an Adenovirus Serotype 26 (Ad26.RSV.preF)-Based Vaccine in Older Adults
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: RSV Vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Multicenter Study of Denture Adhesive
Status: COMPLETED
Conditions: Edentulous
Interventions: OTHER: Denture Adhesives: Cream|OTHER: Denture Adhesives: Powder|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing lymphoDepletion to Improve Outcomes In Patients Receiving Cell Therapy With Yescarta
Status: RECRUITING
Conditions: DLBCL - Diffuse Large B Cell Lymphoma
Interventions: DRUG: Cyclophosphamide|RADIATION: TLI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Preoperative Therapy With Pazopanib (Votrient®) to Treat High-risk Soft Tissue Sarcoma
Status: TERMINATED
Conditions: Sarcoma, Soft-tissue
Interventions: DRUG: pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Mitapivat Sulfate in Adult Patients With Erythrocyte Membranopathies
Status: NOT_YET_RECRUITING
Conditions: Hereditary Red Blood Cell Disorder (Disorder)
Interventions: DRUG: Mitapivat sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Procalcitonin Level and Kinetics in Children With Bacterial Infections
Status: COMPLETED
Conditions: Bacterial Infections|Bacteremia|Meningitis|Urinary Tract Infection|Mastoiditis|Lobar Pneumonia|Septic Arthritis|Cellulitis|Osteomyelitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Generic Versus Reference Cetrorelix Acetate for Ovarian Stimulation Using a Gonadotropin-releasing Hormone（GnRH）Antagonist Protocol in Women Undergoing IVF
Status: RECRUITING
Conditions: Infertility
Interventions: DRUG: Generic cetrorelix acetate|DRUG: Reference cetrorelix acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardioprotective Benefit of Passive Heat Therapy in Higher-Level Spinal Cord Injury: Safety and Proof of Concept
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injuries|Cardiovascular Diseases|Health Behaviour|Physical Inactivity
Interventions: BEHAVIORAL: Passive Heating
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Clinical Trial of CartiLife® in the United States
Status: RECRUITING
Conditions: Articular Cartilage Defect|Articular Cartilage Degeneration
Interventions: DRUG: Autologous Chondrocyte Implantation (CartiLife®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical & Radiographic Evaluation of LSTR in Non-vital Primary Molars Using Two Different Vehicles
Status: UNKNOWN
Conditions: Resorption of Tooth or Root
Interventions: DRUG: Double antibiotic paste mixed with chitosan nanoparticles|DRUG: Double antibiotic paste mixed with propylene glycol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eltrombopag in Elderly Acute Myelogenous Leukemia (AML)
Status: TERMINATED
Conditions: Acute Myelogenous Leukemia (AML)
Interventions: DRUG: Eltrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Mild Cognitive Impairment With Transcutaneous Vagal Nerve Stimulation
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: DEVICE: Transcutaneous vagal nerve stimulation|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Rhomboid Intercostal Block vs Erector Spina Plan Block for Peri-operative Analgesia in Mastectomy
Status: UNKNOWN
Conditions: Analgesia|Perioperative Analgesia|Postoperative Analgesia
Interventions: PROCEDURE: Rhomboid intercostal block|PROCEDURE: Erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Propylene Glycol-Free Melphalan HCl (EVOMELA®) in Combination With Fludarabine and Total Body Irradiation Based Reduced Intensity Conditioning for Haploidentical Transplantation
Status: RECRUITING
Conditions: Hematological Malignancy|Multiple Myeloma
Interventions: DRUG: Evomela|DRUG: Fludarabine|RADIATION: Total Body Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Humoral and Cellular Responses to Vaccination Against Coronavirus Disease 2019 (COVID-19) in the Very Elderly Living in Geriatric Institutions
Status: UNKNOWN
Conditions: Elderly People Institutionalized in Long-term Care Services
Interventions: BIOLOGICAL: Blood test to describe the humoral and cellular response to vaccination BNT162b2 in the elderly
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Long-term Exercise Effects From Robotic Walking
Status: RECRUITING
Conditions: Exercise|Children|Cerebral Palsy
Interventions: OTHER: Exercise - High Intensity Interval Training (HIIT)|OTHER: Exercise - Submaximal Steady State Training (SST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU
Status: RECRUITING
Conditions: Acute Respiratory Distress Syndrome|Acute Hypoxemic Respiratory Failure|Acute Hypercapnic Respiratory Failure
Interventions: OTHER: Toning|OTHER: Ocean drum & SOK melody|OTHER: SOK|BEHAVIORAL: Process|OTHER: Holding Harmonic Container
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Trial on Ladarixin Adjunctive Therapy to Improve Glycemic Control in Type 1 Diabetes.
Status: TERMINATED
Conditions: Type 1 Diabetes
Interventions: DRUG: Ladarixin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chlorhexidine Versus Betadine in Preventing Colonization of Femoral Nerve Catheters After Total Joint Arthroplasty (TJA)
Status: WITHDRAWN
Conditions: Infection
Interventions: DRUG: Skin antisepsis with chlorhexidine|DRUG: povidone-iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Two Atypical Antipsychotics vs. Placebo in Patients With an Acute Exacerbation of Either Schizophrenia or Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: risperidone, quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Serratus and Parasternal Infrapectoral Block for Breast Surgery.
Status: RECRUITING
Conditions: Breast Pain|Post-Op Complication
Interventions: PROCEDURE: Unilateral serratus plane block|PROCEDURE: Unilateral parasternal infrapectoral block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diurnal Curves With Bimatoprost 0.03% Versus Travoprost 0.004%
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Bimatoprost 0.03%, Travoprost 0.004%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose:
Clinical trial: Acipimox to Improve Hyperlipidemia and Insulin Sensitivity Associated With HIV
Status: COMPLETED
Conditions: Insulin Resistance|Cardiovascular Diseases|Heart Diseases|HIV Infections|Hypertriglyceridemia|Hyperlipidemia
Interventions: DRUG: Acipimox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Influence of Calcium Pattern on Plaque Modification Achieved With Intracoronary Lithotripsy
Status: COMPLETED
Conditions: Coronary Artery Disease|Intracoronary Lithotripsy|Optical Coherence Tomography|Percutaneous Coronary Intervention|Calcification|Stent
Interventions: DEVICE: Intracoronary lithotripsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase II Trial Using Meloxicam Plus Filgrastim in Patients With Multiple Myeloma and Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Multiple Myeloma|Non-Hodgkin's Lymphoma
Interventions: DRUG: Meloxicam|DRUG: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effectiveness of Transcranial Direct Current Stimulation on Obsessive Compulsive Disorder
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: Transcramial Direct current stimulation|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in Adults With Generalized Pustular Psoriasis
Status: COMPLETED
Conditions: Generalized Pustular Psoriasis
Interventions: BIOLOGICAL: Imsidolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Evaluation of 4-month Regimen of OPC-167832, Delamanid and Bedaquiline in Participants With Drug-Susceptible Pulmonary TB
Status: COMPLETED
Conditions: Pulmonary TB
Interventions: DRUG: Delamanid + Bedaquiline + OPC-167832 10 mg|DRUG: Delamanid + Bedaquiline + OPC-167832 30 mg|DRUG: Delamanid + Bedaquiline + OPC-167832 90 mg|DRUG: RHEZ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabetic Retinopathy in HIV Subjects Treated With EGRIFTA®
Status: TERMINATED
Conditions: Diabetic Retinopathy|HIV
Interventions: DRUG: Tesamorelin|DRUG: Placebo-Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vascular Reactivity in Kidney Disease Patients
Status: COMPLETED
Conditions: Kidney Failure, Chronic|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: PROCEDURE: Changing hemoglobin concentration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety, Tolerability and Pharmacokinetic Study of HEC68498 in Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: HEC 68498|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy (CBT) After Lumbar Spinal Fusion in Patients With High Pain Catastrophizing
Status: UNKNOWN
Conditions: Lumbar Spinal Stenosis|Lumbar Spondylolisthesis|Lumbar Instability|Spinal Disease
Interventions: BEHAVIORAL: Cognitive-behavioral Therapy|OTHER: Biomedical and surgery-specific education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation to Assess the Clinical Performance of the LumbaCure® Intervention on Chronic Low Back Pain Patients.
Status: RECRUITING
Conditions: Chronic Low Back Pain
Interventions: DEVICE: LumbaCure®|PROCEDURE: Physical Exercises supervised by the physiotherapist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Inhaled RNS60 in Combination With Budesonide to Treat Mild to Moderate Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: RNS60|DRUG: Normal Saline|DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Autologous Blood Injection Versus Diluted Epinephrine in Treating Actively Bleeding Gastroduodenal Ulcers
Status: COMPLETED
Conditions: Blood, Injection, Injury Type Phobia|Gastrointestinal Ulcer Haemorrhage|Adverse Reaction to Epinephrine
Interventions: DRUG: Epinephrine|BIOLOGICAL: Blood
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Weekly Dosing of D-cycloserine on Cognitive Function in Individuals With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: d-cycloserine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Weight Loss With Risedronate for Bone Health
Status: COMPLETED
Conditions: Bariatric Surgery Candidate|Bone Loss|Weight Loss
Interventions: DRUG: Risedronate Sodium 150 MG|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lung Expansion Technics on Chest Wall Mechanics and Preventing Pulmonary Complication After Abdominal Surgery
Status: COMPLETED
Conditions: Surgical Procedure, Unspecified
Interventions: PROCEDURE: Breathing exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Disease Activity and Safety of Subcutaneous Lutikizumab (ABT-981) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-Tumor Necrosis Factor (TNF) Therapy and Who Are Naïve to Biologic Therapy
Status: RECRUITING
Conditions: Hidradenitis Suppurativa
Interventions: BIOLOGICAL: Lutikizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing Foot Injuries in Infantry Recruits Wearing Different Boots
Status: COMPLETED
Conditions: Blister|Abrasion|Stress Fracture|Ankle Sprain|Patellofemoral Pain Syndrome|Back Pain
Interventions: DEVICE: Experimental infantry boot - DEFINITE-REGULATOR|DEVICE: Control infantry boot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Discovering Early Biomarkers in Circulating Endothelial Cells for Diabetes Complications by Single Cell RNA Sequencing
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus|Proliferative Diabetic Retinopathy|Diabetic Maculopathy|Circulating Endothelial Cells
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Pembrolizumab and Lenvatinib in Patients With Anaplastic Thyroid Cancer
Status: RECRUITING
Conditions: Anaplastic Thyroid Cancer
Interventions: DRUG: Pembrolizumab + Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Pegylated Interferon Lambda Monotherapy in Patients With Chronic Hepatitis Delta Virus Infection
Status: COMPLETED
Conditions: Hepatitis D, Chronic
Interventions: DRUG: Peginterferon Lambda-1A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glaucoma, Visual Field Loss, and Their Association With Life Space in Older Adults
Status: RECRUITING
Conditions: Primary Open Angle Glaucoma
Interventions: DIAGNOSTIC_TEST: Life Space Questionnaire|DIAGNOSTIC_TEST: Low Luminance Questionnaire|DIAGNOSTIC_TEST: Contrast sensitivity under dim illumination|DIAGNOSTIC_TEST: Visual field under dim illumination (MAIA)|DIAGNOSTIC_TEST: Macular Pigment Optical Density (MPOD)|DIAGNOSTIC_TEST: Dark Adaptation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study of Bioequivalence of Cudafol(R) and Diprivan(R) Administered as Single Intravenous Doses in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Cudafol(R) (propofol, 1% [10 mg/mL])|DRUG: Diprivan(R) (propofol, 1% [10 mg/mL])
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Single Dose Study of PF-05230907 in Healthy Japanese Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-05230907|DRUG: PF-05230907|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Relative Bioavailability of Three Immediate-Release Tablet Formulations of ABBV-903 in Healthy Adult Volunteers
Status: NOT_YET_RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: ABBV-903
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Endotracheal Intubation Over the Aintree With Fiberoptic Bronchoskop Via the I-gel and LMA Protector
Status: UNKNOWN
Conditions: Intubation;Difficult
Interventions: DEVICE: LMA protector|DEVICE: I-gel LMA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Effectiveness of the Nit-Occlud® Lê VSD Spiral Coil System
Status: COMPLETED
Conditions: Heart Septal Defects, Ventricular
Interventions: DEVICE: transcatheter implantation of a VSD occluder (Nitinol coil)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of NNC0141-0000-0100 in Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Inflammation|Rheumatoid Arthritis
Interventions: DRUG: NNC 0141-0000-0100|DRUG: placebo|DRUG: NNC 0141-0000-0100|DRUG: placebo|DRUG: NNC 0141-0000-0100|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigator-initiated Clinical Trial (Phase II) of Cancer Vaccine "Dainippon Sumitomo Phama(DSP)-7888" for Acute Myeloid Leukemia Patients.
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia in Remission
Interventions: DRUG: DSP-7888
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Pembrolizumab After Curative Intent Treatment for Oligometastatic Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Oligometastatic Non-small Cell Lung Cancer (NSCLC)
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: Outpatient Cardiac Tele-Rehabilitation in a Public Sports Center
Status: UNKNOWN
Conditions: Acute Coronary Syndrome|Cardiac Rehabilitation|Telerehabilitation|Secondary Prevention|Wearable Electronic Devices|Exercise Therapy
Interventions: PROCEDURE: Cardiac Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lazertinib & Tepotinib for EGFR Mutant NSCLC in MET Overexpressed or Amplified Who Progressed After Lazertinib Treatment
Status: NOT_YET_RECRUITING
Conditions: Non-Small Cell Lung Cancer Metastatic
Interventions: DRUG: Lazertinib|DRUG: Tepotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Zeaxanthin and Visual Function Study
Status: COMPLETED
Conditions: Age Related Macular Degeneration|Cognition Disorders
Interventions: DRUG: 3R 3'R Zeaxanthin|DIETARY_SUPPLEMENT: Lutein|DIETARY_SUPPLEMENT: Lutein and Zeaxanthin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Kinematic, Kinetic, and Metabolic Comparison of Bilateral Transfemoral Ambulation With Passive Versus Powered Prosthetic Devices
Status: UNKNOWN
Conditions: Amputation|Artificial Limbs|Energy Expenditure|Kinetics
Interventions: DEVICE: Lower Limb Powered Knee-Ankle Prosthesis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial To Find Out If Vidutolimod Together With Cemiplimab Is Safe And If It Works In Adult Participants With Advanced Cancer Or Metastatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Merkel Cell Carcinoma|Cutaneous Squamous Cell Carcinoma|Basal Cell Carcinoma|Triple Negative Breast Cancer|Non-Small Cell Lung Cancer|Oropharynx Squamous Cell Carcinoma
Interventions: DRUG: vidutolimod|DRUG: cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of The Effects Of OC000459 In Subjects Known To Suffer From Grass Pollen Induced Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: OC000459|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Alternative Antibiotic Regime in the Treatment of GAgP
Status: COMPLETED
Conditions: Generalized Aggressive Periodontitis|Aggressive Periodontitis
Interventions: DRUG: Amoxicillin|DRUG: Metronidazole|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Single Shot Fascia Iliaca Block vs Femoral Nerve Block for Analgesia for Surgical Fixation of Hip Fractures
Status: COMPLETED
Conditions: Hip Fracture
Interventions: DRUG: Ropivacaine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of DFN-02 (Sumatriptan Nasal Spray 10 mg)
Status: COMPLETED
Conditions: Migraine Headaches
Interventions: DRUG: Sumatriptan 10 mg Nasal Spray|OTHER: Sumatriptan Placebo Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physiological-based Cord Clamping in Congenital Diaphragmatic Hernia
Status: RECRUITING
Conditions: Hernias, Diaphragmatic, Congenital|Hernia; Diaphragm Defect, Congenital|Pulmonary Hypertension
Interventions: PROCEDURE: Physiological-based cord clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Structural and Functional Changes in Supraspinatus Tendinopathy Thtough Percutaneous Electrolysis and Neuromodulation Combined Therapy. A Single-blinded Randomized clínical Trial.
Status: COMPLETED
Conditions: Supraspinatus Tendinitis
Interventions: OTHER: Experimental Group|OTHER: Conventional group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalency Study of Amlodipine Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Hypertension|Chronic Stable Angina|Vasospastic Angina
Interventions: DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-Significant Risk Study Comparing the Nautilus NeuroWaveTM to Transcranial Doppler as an Aid to Diagnosing Vasospasm
Status: COMPLETED
Conditions: Cerebral Vasospasm
Interventions: DEVICE: Nautilus NeuroWave|DEVICE: Transcranial Doppler (TCD)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Perioperative Immunotherpay Versus Adjuvant Immunotherapy for Resectable Non-small Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Stage II-IIIB(N2) Non-small Cell Lung Cancer
Interventions: DRUG: TQB2450|DRUG: Carboplatin|DRUG: Pemetrexed|DRUG: Nab-paclitaxel|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A "Negative"Dendritic Cell-based Vaccine for the Treatment of Multiple Sclerosis: a First-in-human Clinical Trial
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: BIOLOGICAL: tolerogenic dendritic cells (tolDC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Compare to 2-channel and Multiple-channel Single Port Laparoscopic-assisted Vaginal Hysterectomy
Status: UNKNOWN
Conditions: Myoma|Adenomyosis
Interventions: DEVICE: comparison multiple channel port laparoscopic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immune Checkpoint Inhibitor and MR-guided SBRT for Limited Progressive Metastatic Carcinoma.
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Carcinoma
Interventions: RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Non-invasive Brain Stimulation in Impulse Control Disorders
Status: UNKNOWN
Conditions: Impulse Control Disorder
Interventions: DEVICE: Noninvasive brain stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Evaluate the Efficacy of Afatinib in Advanced Lung Squamous Cell Carcinoma With EGFR Sensitive Mutation
Status: UNKNOWN
Conditions: Lung Squamous Cell Carcinoma
Interventions: DRUG: Afatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Immunogenicity of Alveavax-v1.2, a BA.2/Omicron-optimized, DNA Vaccine for COVID-19 Prevention
Status: COMPLETED
Conditions: Sars-CoV-2 Infection
Interventions: DRUG: Alveavax-v1.2|DRUG: Janssen Ad26.COV2.S
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of a Mobile Clinical Decision Support System (CaPtyVa CCR App) to Improve Performance of Gastroenterology and Coloproctology Specialists in Colorectal Cancer Screening and Surveillance According to Guideline Recommendations: A Randomized Clinical Trial.
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DEVICE: CaPtyVa app|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Buccal Midazolam Versus Nasal or Oral Midazolam Sedation for Minor Invasive Procedures in Children
Status: UNKNOWN
Conditions: Dormicum|Conscious Sedation|Children
Interventions: DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Evaluation of Two Protocol of Maxillary Protraction in Class III Adolescent After Using (MSE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Maxillary Protraction in Class III Adolescent After Using (MSE)
Interventions: DEVICE: Maxillary skeletal expander with protraction face mask with Alt-RAMEC protocol.|DEVICE: Maxillary skeletal expander with protraction face mask with conventional protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rapid Research in Diagnostics Development for TB Network (R2D2 Kids) and Assessing Diagnostics At POC for TB in Children (ADAPT for Kids)
Status: RECRUITING
Conditions: Tuberculosis|Diagnostics|Global Health
Interventions: DIAGNOSTIC_TEST: Oral swab molecular testing|DIAGNOSTIC_TEST: Automated Cough Sound Analysis|DIAGNOSTIC_TEST: Automated Lung Sound Analysis|OTHER: Chest X Ray Computer Aided Detection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Efficacy, Immune Response, and Safety of a COVID-19 Vaccine in Adults ≥ 18 Years With a Pediatric Expansion in Adolescents (12 to<18 Years) at Risk for SARS-CoV-2
Status: COMPLETED
Conditions: SARS-CoV Infection|Covid19
Interventions: BIOLOGICAL: SARS-CoV-2 rS/Matrix-M1 Adjuvant (Initial Vaccination Period)|OTHER: Placebo (Initial Vaccination Period)|BIOLOGICAL: SARS-CoV-2 rS/Matrix-M1 Adjuvant (Crossover Vaccination period)|OTHER: Placebo (Crossover Vaccination period)|BIOLOGICAL: SARS-CoV-2 rS/Matrix-M1 Adjuvant (Booster Vaccination)|BIOLOGICAL: SARS-CoV-2 rS/Matrix-M1 Adjuvant (Second Booster Vaccination)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Role of Capsule Endoscopy in the Evaluation of Mucosal Changes During Treatment of Patients With Active Crohn's Disease
Status: UNKNOWN
Conditions: Crohn's Disease
Interventions: DEVICE: PillCam® COLON 2 and PillCam Crohn's capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Scintigraphic Study to Investigate the Effect of Gelesis100 on Gastric Emptying in Overweight and Obese Subjects
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: DEVICE: Gelesis100|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Fecal Microbiota Transplantation in Patients With Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome (IBS)
Interventions: OTHER: Fecal transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone or Dexamethasone in Combination With Thalidomide as Salvage Therapy
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Thalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Characterization of Blood Volumes of Commercially Available Lancing Devices
Status: COMPLETED
Conditions: Diabetes
Interventions: DEVICE: Delica Lancing Device|DEVICE: Flash Lancing Device|DEVICE: Easy Touch Lancing Device|DEVICE: Glucoject Lancing Device|DEVICE: Microlet Lancing Device|DEVICE: Multiclix Lancing Device|DEVICE: Fastclix Lancing Device|DEVICE: Reli-On Lancing Device
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of LibiGel® for the Treatment of Hypoactive Sexual Desire Disorder in Surgically Menopausal Women
Status: COMPLETED
Conditions: Hypoactive Sexual Desire Disorder
Interventions: DRUG: testosterone gel|DRUG: placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess Safety and Efficacy of Ambrisentan in Subjects With Pulmonary Arterial Hypertension.
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: ambrisentan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Fenofibrate and Omega-3 Fatty Acid Modulation of Endotoxemia
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DRUG: Fenofibrate (Tricor) tablets|DRUG: Placebo|DRUG: Lovaza
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Follicle Stimulating Hormone (FSH) Glycosylation in Women: Effect of Estradiol
Status: UNKNOWN
Conditions: Follicle Stimulating Hormone Glycosylation|Urinary FSH21/FSH24 Ratio|Estradiol Effect
Interventions: DRUG: Estradiol Transdermal Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Orthodontic Treatment With a Part-Time Wearing Esthetic Removable Appliance
Status: UNKNOWN
Conditions: Malocclusion
Interventions: PROCEDURE: orthodontic treatment with "Rafenalign" appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on Postmarketing Xuezhikang Capsule for Treating Dyslipidemia
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: Xuezhikang capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to the Impact of Accuracy Problem Lists in Electronic Health Records on Correctness and Speed of Clinical Decision-making Performed by Dutch Healthcare Providers
Status: COMPLETED
Conditions: Clinical Decision-Making|Decision Making, Computer-assisted|Medical Records, Problem-Oriented|Quality of Health Care|Evidence-Based Practice|Data Accuracy|Documentation / Standards|Documentation / Statistics & Numerical Data|Forms and Records Control / Standards|Humans|International Classification of Diseases / Standards
Interventions: OTHER: patient A with accurate problem list|OTHER: patient B with inaccurate problem list|OTHER: patient A with inaccurate problem list|OTHER: patient B with accurate problem list
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Pharmacokinetic, Pharmacodynamic, Safety and Tolerability Study of CERC-006 in Adults With Complex Lymphatic Malformations
Status: WITHDRAWN
Conditions: Lymphatic Malformation
Interventions: DRUG: CERC-006
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Dose Escalation Study FTIM in Order to Assess Safety and Tolerability of GSK610677
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK610677|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: |Primary Purpose: TREATMENT