pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of Intravitreal Injections of 2.0mg Ranibizumab in Subjects With Chronic Fluid On OCT Post Multiple Injections With Ranibizumab (Super-dose Anti-VEgf SAVE Trial)
Status: TERMINATED
Conditions: Age Related Macular Degeneration|Choroidal Neovascular Membrane|Subfoveal Neovascular Age-Related Macular Degeneration|Macular Degeneration|Wet Age-Related Macular Degeneration
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Denosumab in Treating Patients With Bone Loss Due to Donor Stem Cell Transplant
Status: COMPLETED
Conditions: Allogeneic Hematopoietic Stem Cell Transplantation Recipient|Osteopenia|Osteoporosis
Interventions: BIOLOGICAL: Denosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Two ECG Guided PICC Insertion Techniques
Status: COMPLETED
Conditions: Central Venous Access|Long Term Antibiotics|Chemotherapy|Total Parenteral Nutrition
Interventions: DEVICE: LifeCath-CT PICC easy™ (Vygon)|DEVICE: PowerPICC-SOLO® (C.R. Bard)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prevention of Infection in Closed Fractures: Cefazolin Versus Vancomycin
Status: TERMINATED
Conditions: Infection|Closed Fractures
Interventions: DRUG: Cefazolin|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Compassionate Use of 131I-MIBG for Patients With Malignant Pheochromocytoma
Status: APPROVED_FOR_MARKETING
Conditions: Pheochromocytoma|Paraganglioma
Interventions: DRUG: 131 I-Metaiodobenzylguanidine (131 I-MIBG)
Study Type: EXPANDED_ACCESS
Clinical trial: A Clinical Trial of Cognitive Multisensory Rehabilitation for Sensory and Motor Recovery in Adults With Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: BEHAVIORAL: Cognitive Multisensory Rehabilitation (CMR)|BEHAVIORAL: Adaptive fitness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study Of Aurora Kinase Inhibitor PF-03814735 In Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: PF-03814735
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Supplementation With Tocotrienol on Chronic Kidney Disease Patients
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Hemodialysis|Microbiota|Oxidative Stress|Inflammation
Interventions: DIETARY_SUPPLEMENT: Tocotrienol rich fraction|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cognitive Processing Therapy Versus Its Individual Components in the Treatment of Post-Traumatic Stress Disorder and Depression in Women Who Have Been Sexually Abused
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: BEHAVIORAL: Cognitive Therapy|BEHAVIORAL: Cognitive Processing Therapy|BEHAVIORAL: Written Exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Procedural Sedation With Propofol and Dexmedetomidine During Transcatheter Aortic Valve Implantation
Status: COMPLETED
Conditions: Transcatheter Aortic Valve Replacement|Procedural Sedation
Interventions: DRUG: Propofol|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Clinical Trial of SBRT and Systemic Pembrolizumab With or Without Avelumab/Ipilimumab+ Dendritic Cells in Solid Tumors
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer|Solid Tumor
Interventions: DRUG: Avelumab|DRUG: Ipilimumab 5 MG/ML|DRUG: Pembrolizumab 100 MG in 4 ML Injection|OTHER: CD1c (BDCA-1)+ / CD141 (BDCA-3)+ myDC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence
Status: COMPLETED
Conditions: Cocaine Dependence|Alcoholism
Interventions: DRUG: Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Genetic Basis for Heterogeneity in Response of Plasma Lipids to Plant Sterols
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DIETARY_SUPPLEMENT: Plant sterol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Resistant Metastatic Melanoma Using Decitabine, Temozolomide and Panobinostat
Status: TERMINATED
Conditions: Metastatic Melanoma
Interventions: DRUG: Temozolomide, Decitabine, Panobinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Doxycycline to Protect Heart Muscle After Heart Attacks
Status: RECRUITING
Conditions: ST Segment Elevation Myocardial Infarction|Heart Failure
Interventions: DRUG: Placebo|DRUG: Doxycycline Hyclate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Omega-3 Fatty Acids Versus Gabapentin in Uremic Pruritus in Hemodialysis Patients
Status: COMPLETED
Conditions: Uremic Pruritus in Hemodialysis Patients
Interventions: DRUG: Omega 3 fatty acid, gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing Transnasal humidiﬁed Rapid insufﬂation Ventilatory Exchange (THRIVE) and Apneic Oxygenation With Facemask Ventilation in Elderly Patients Undergoing Induction of Anaesthesia.
Status: UNKNOWN
Conditions: Anesthesia Intubation Complication|Postoperative Complications
Interventions: DEVICE: Transnasal humidified rapid insufflation ventilatory exchange (THRIVE)|DEVICE: Facemask ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Metformin Treatment Before in Vitro Fertilization (IVF) in Women With Ultrasound Evidence of Polycystic Ovaries
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-42756493 in Patients With Advanced or Refractory Solid Tumors or Lymphoma
Status: COMPLETED
Conditions: Neoplasms|Lymphoma|Adenocarcinoma|Esophagogastric Junction
Interventions: DRUG: Part 1: JNJ-42756493|DRUG: Part 2: JNJ-42756493
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Homocysteine in Myocardial Infarction Patients in a Tertiary Care Hospital of Pakistan
Status: WITHDRAWN
Conditions: Homocystine; Metabolic Disorder
Interventions: DIAGNOSTIC_TEST: Homocysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study on Tumor Budding Guiding Individualized Surgical Planning of Early-stage Oral Squamous Cell Carcinoma.
Status: RECRUITING
Conditions: Carcinoma, Squamous Cell
Interventions: PROCEDURE: Resection for primary lesion and cervical lymph node dissection|PROCEDURE: Resection for primary lesion only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modified HFNC Therapy for ARF Patients Undergoing Flexible Bronchoscopy
Status: RECRUITING
Conditions: Acute Hypoxemic Respiratory Failure|High-flow Nasal Cannula Oxygen
Interventions: DEVICE: Modified HFNC oxygen therapy|DEVICE: Face mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Remote Ischemic Preconditioning on the Ischemic Reperfusion Injury in Infants With Ventricular Septal Defect and Pulmonary Hypertension
Status: COMPLETED
Conditions: Ventricular Septal Defect|Pulmonary Hypertension
Interventions: OTHER: remote ischemic preconditioning (RIPC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Everolimus in Liver Transplant Recipients of Living Donor Liver Transplants
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: DRUG: Everolimus + reduced tacrolimus|DRUG: Standard tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: ImpRoving hEalth behaviourS for LIfe After ENdometrial CancEr Trial
Status: RECRUITING
Conditions: Endometrial Cancer
Interventions: BEHAVIORAL: Digital wellness platform|BEHAVIORAL: Online healthcare professional support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Primary Care Detection of Cognitive Impairment Leveraging Health & Consumer Technologies in Underserved Communities: The MyCog Trial
Status: RECRUITING
Conditions: Dementia|Cognitive Impairment|Cognitive Decline|Alzheimer Disease
Interventions: DIAGNOSTIC_TEST: MyCog
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Positive Association of US-FLI With the Severity of CAD
Status: RECRUITING
Conditions: Coronary Artery Disease of Significant Bypass Graft|Metabolic Dysfunction-associated Fatty Liver Disease|SYNTAX Score|Ultrasonography
Interventions: OTHER: Observational study without human intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigation of Anti-tumour Effect and Tolerability of the PARP Inhibitor 2X-121 in Patients With Metastatic Breast Cancer Selected by the 2X-121 DRP
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: PARP inhibitor 2X-121
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated Pencil-Beam Scanning Intensity-modulated Proton Therapy (IMPT) in Recurrent Rectal Cancer
Status: RECRUITING
Conditions: Recurrent Rectal Cancer
Interventions: RADIATION: Hypofractionated Pencil-Beam Scanning Intensity-modulated Proton Therapy|DEVICE: MEVION S250i Hyperscan and Adaptive Aperture Proton Therapy Machine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telehealth Could Mitigate Disease Progression Compared to Standard of Care in COPD - a Randomized Controlled Trial
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Telehealth care|DIAGNOSTIC_TEST: Weekly CAT measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Immune Response and the Safety Profile of a High-Dose Quadrivalent Influenza Vaccine (QIV-HD) Compared to a Standard-Dose Quadrivalent Influenza Vaccine (QIV-SD) in Japanese Adults 60 Years of Age and Older
Status: COMPLETED
Conditions: Influenza Immunization|Healthy Volunteers
Interventions: BIOLOGICAL: High-Dose Quadrivalent Influenza Vaccine, (Zonal Purified, Split Virus) 2020-2021 Strains (QIV-HD)|BIOLOGICAL: Local Standard-Dose Inactivated Quadrivalent Influenza Vaccine, 2020-2021 Strains (QIV-SD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Sub-retinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigmented Epithelial (hESC-RPE) Cells in Patients With Stargardt's Macular Dystrophy (SMD)
Status: COMPLETED
Conditions: Stargardt's Macular Dystrophy
Interventions: BIOLOGICAL: MA09-hRPE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Alirocumab for Thin-cap fIbroatheroma in Patients With Coronary Artery Disease Estimated by Optical Coherence Tomography
Status: UNKNOWN
Conditions: Coronary Artery Disease|Thin-cap fIbroatheroma
Interventions: DRUG: Alirocumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: XIENCE Xpedition Everolimus-Eluting Coronary Stent Japan Post Marketing Surveillance (XIENCE Xpedition SV Japan PMS)
Status: COMPLETED
Conditions: Ischemic Heart Disease|Angina Pectoris|Coronary Artery Disease|Myocardial Ischemia
Interventions: DEVICE: XIENCE Xpedition 2.25 mm stent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Combination Therapy With Amivantamab and Docetaxel in Participants With Metastatic Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Amivantamab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effect of Trigger Point Injection and EMLA for Shoulder Pain in Laparoscopic Hysterectomy
Status: COMPLETED
Conditions: Myoma of Uterus
Interventions: DRUG: TPI|DRUG: EMLA cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of Bone Marrow-derived Cellular Therapy in Progressive Multiple Sclerosis (ACTiMuS)
Status: UNKNOWN
Conditions: Progressive Multiple Sclerosis
Interventions: OTHER: Early infusion of autologous marrow|OTHER: Late infusion of autologous marrow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral and Neurophysiological Effects of Multichannel Executive Network tDCS Combined With Preferred Music Stimulation
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: tDCS|DEVICE: Sham tDCS|OTHER: Music|OTHER: White noise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Treat Relapsed Follicular Non-Hodgkin's Lymphoma With Radiation and Bexxar
Status: TERMINATED
Conditions: Non-Hodgkin's Lymphoma|Follicular Lymphoma
Interventions: DRUG: Iodine I -01 Tositumomab (Bexxar)|PROCEDURE: External Beam Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CINRYZE as a Donor Pre-treatment Strategy in Kidney Recipients of KDPI>60%
Status: UNKNOWN
Conditions: Kidney Failure
Interventions: DRUG: Placebo saline solution|DRUG: Heparin|DRUG: CINRYZE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Apatinib Combined With PLD vs PLD for Platinum-resistant Recurrent Ovarian Cancer
Status: UNKNOWN
Conditions: Platinum-resistant Recurrent Ovarian Cancer
Interventions: DRUG: PLD 40mg/m2 ivgtt q4w +Apatinib 250mg po qd|DRUG: PLD 40mg/m2 ivgtt q4w
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Achilles Tendon Rupture - Choice of Treatment Based on Ultrasound Findings
Status: ACTIVE_NOT_RECRUITING
Conditions: Achilles Tendon Rupture|Athletic Injuries|Ultrasonography|Rupture|Acute Disease
Interventions: PROCEDURE: Surgical treatment|OTHER: Non-surgical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Persistence of Immunity in 4-year-old Children Previously Immunised With IPV-Al AJV (Picovax®)
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: IPV-Al
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Image-guided Breast Surgery in the Advanced Multimodality Image Guided Operating Suite (AMIGO)
Status: COMPLETED
Conditions: Stage I Breast Carcinoma|Stage II Breast Carcinoma
Interventions: DEVICE: intra-operative MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: TEG (Thromboelastography) Based Versus Conventional Coagulation Parameters Based Correction of Coagulopathy in Non Variceal Bleed.
Status: COMPLETED
Conditions: Non Variceal Bleed
Interventions: BIOLOGICAL: Fresh Frozen Plasma|BIOLOGICAL: Platelets Concentrate|BIOLOGICAL: Cryo Precitipitate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Vivatlac Synbiotikum in Patients With Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Vivatlac Synbiotikum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Doxepin Hydrochloride in Treating Esophageal Pain in Patients With Thoracic Cancer Receiving Radiation Therapy to the Thorax With or Without Chemotherapy
Status: TERMINATED
Conditions: Esophageal Carcinoma|Hypopharyngeal Carcinoma|Laryngeal Carcinoma|Lymphoma|Mesothelioma|Metastatic Malignant Neoplasm in the Lung|Metastatic Malignant Neoplasm in the Pleura|Metastatic Malignant Neoplasm in the Spinal Cord|Non-Small Cell Lung Carcinoma|Sarcoma|Small Cell Lung Carcinoma|Thymic Carcinoma|Thymoma|Thyroid Gland Carcinoma
Interventions: DRUG: Doxepin Hydrochloride|OTHER: Placebo|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A 4 Week Study to Investigate the Safety and Tolerability of AZD5069 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Scientific Terminology Chronic Obstructive Pulmonary Disease (COPD)|Laymen Terminology Chronic Bronchitis and Emphysema
Interventions: DRUG: Placebo|DRUG: AZD5069 50mg|DRUG: AZD5069 80mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tilelizumab Combined With Nab-Paclitaxel for High-Risk Non-Muscle-Invasive Urothelial Bladder Carcinoma Which is Not Completely Resectable
Status: UNKNOWN
Conditions: High-Risk|Non-Muscle Invasive Bladder Urothelial Carcinoma
Interventions: DRUG: Tislelizumab|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: National Cohort Study of Effectiveness and Safety of SARS-CoV-2/COVID-19 Vaccines (ENFORCE)
Status: COMPLETED
Conditions: SARS-CoV Infection
Interventions: BIOLOGICAL: COMIRNATY - BioNTech Manufacturing GmbH|BIOLOGICAL: COVID-19 Vaccine Moderna dispersion for injection - MODERNA BIOTECH|BIOLOGICAL: COVID-19 Vaccine AstraZeneca suspension for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Safety and Efficacy of the Combination Product QVA149A Against the Concurrent Administration of the Individual Components, QAB149 and NVA237, in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: QVA149|DRUG: NVA237|DRUG: QAB149|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Cyclooxygenase (COX) 1-2 Inhibitors on Prevention of Rocuronium Injection Pain
Status: COMPLETED
Conditions: Injection Site Irritation
Interventions: DRUG: Dexketoprofen (KETAVEL 50 mg/2 ml)|DRUG: Saline (Isotonic Saline Solution 0.9% )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study to Evaluate the Pharmacokinetic Characteristics Between TMX-67 and Feburic® in Healthy Volunteers
Status: COMPLETED
Conditions: Gout
Interventions: DRUG: Feburic®|DRUG: TMX-67
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of Intra-operative Peritoneal Lavage With Super Oxidized Solution and Normal Saline in Peritonitis Cases
Status: COMPLETED
Conditions: Peritonitis
Interventions: PROCEDURE: Super Oxidized Solution in group I
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing the Bowel Cleansing Efficacy of PLENVU® Versus SELG-ESSE® Using a 2-Day Split Dosing Regimen.
Status: COMPLETED
Conditions: Colon Polyp|Colon Adenoma|Colon Lesion
Interventions: DRUG: PEG3350|DRUG: Macrogol 4000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Efficacy and Safety of 2.5mg and 5mg Tadalafil Given Once a Day to Men With Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: tadalafil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Risk of Falling After CFNB Versus ACB
Status: COMPLETED
Conditions: Falls|Total Knee Arthroplasty (TKA)|Osteoarthritis
Interventions: PROCEDURE: adductor canal block|PROCEDURE: femoral nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Evaluate Whether Acetyl Salicylic Acid (Aspirin) and Darexaban (YM150) Interact in Their Effects
Status: COMPLETED
Conditions: Pharmacodynamic and Pharmacokinetic Interaction|Healthy Subjects
Interventions: DRUG: Darexaban|DRUG: Acetyl Salicylic Acid (ASA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Effect of DapagliFLOzin on Quality of Life in Patients With Type 2 Diabetes in a Real Clinical PrActice
Status: WITHDRAWN
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: Dapagliflozin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Doxorubicin Before Mastectomy in Treating Women With Invasive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Intraductal arm|DRUG: Intravenous arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men to Test the Influence of BI 1323495 on the Amount of the Medicines Rosuvastatin and Dabigatran in the Blood
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rosuvastatin|DRUG: Rosuvastatin + BI 1323495|DRUG: Dabigatran etexilate|DRUG: Dabigatran etexilate + BI 1323495
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Glycemic and Insulinemic Response of FOSSENCE™
Status: COMPLETED
Conditions: Dietary Modification|Healthy
Interventions: DIETARY_SUPPLEMENT: scFOS|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: HAIC With One-day FOLFOX vs. HAIC With Two-day FOLFOX for Unresectable HCC: a Non-inferiority Study
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: HAIC|DRUG: FOLFOX 2d|DRUG: FOLFOX 1d
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hormone Therapy Or Chemotherapy Before Surgery Based on Gene Expression Analysis in Treating Patients With Breast Cancer
Status: COMPLETED
Conditions: Ductal Breast Carcinoma in Situ|Lobular Breast Carcinoma in Situ|Stage II Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer
Interventions: PROCEDURE: Neoadjuvant Therapy|PROCEDURE: Therapeutic Conventional Surgery|OTHER: Laboratory Biomarker Analysis|GENETIC: Gene Expression Analysis|DRUG: Systemic Chemotherapy|DRUG: Tamoxifen Citrate|DRUG: Aromatase Inhibition Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Buprenorphine, Clonidine, and Dexamethasone on Duration of Brachial Plexus Blocks for Upper Extremity Surgery
Status: RECRUITING
Conditions: Pain, Postoperative
Interventions: DRUG: Interscalene block with the addition of buprenorphine, clonidine, dexamethasone|DRUG: Interscalene block with buprenorphine alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of CEP-37250/KHK2804 in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumour|Adenocarcinoma of the Colorectal|Adenocarcinoma of the Pancreas
Interventions: DRUG: CEP-37250/KHK2804
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shoulder Passive Range of Motion and Positioning Exercise on Hemiplegic Stroke Patients
Status: COMPLETED
Conditions: Shoulder Pain|Hemiplegia|Stroke|Rotator Cuff Injury
Interventions: OTHER: video-teaching|OTHER: oral-teaching|OTHER: regular rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Tolerance and Pharmacokinetic Study of Trodusquemine in Healthy Volunteers
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: trodusquemine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study Of E7389, Halichondrin B Analogue, In Patients With Advanced Non-Small Cell Lung Cancer, NSCLC, Who Progressed During Or After Platinum-Based Doublet Chemotherapy
Status: COMPLETED
Conditions: Non-Small-Cell Lung Carcinoma
Interventions: DRUG: E7389 28 Day Cycle|DRUG: E7389 21 Day Cycle
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy And Motor Learning Technique Among Attention Deficit Hyperactivity Disorder Adults
Status: NOT_YET_RECRUITING
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: cognitive behavioral therapy|BEHAVIORAL: Motor Learning Techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Lateral Epicondylalgia in Handgun Olympic Shooting Athletes
Status: ENROLLING_BY_INVITATION
Conditions: Epicondylitis, Lateral
Interventions: OTHER: Exercise and stretching programe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: How Glargine Insulin, Oral Diabetes Medications and Exenatide May Improve Blood Sugar Control and Weight Gain in Type 2 Diabetics
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: exenatide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Savolitinib for Treating Gastric Cancer and Esophagogastric Junction Adenocarcinoma Patients
Status: RECRUITING
Conditions: Gastric Cancer|Esophagogastric Junction Disorder
Interventions: DRUG: Savolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of the Lithuanian Version of the BNSS, CDSS, and the SCoRS
Status: RECRUITING
Conditions: Schizophrenia|Negative Symptoms in Schizophrenia|Depressive Symptoms Due to Primary Psychotic Disorder (Diagnosis)|Cognitive Deficit
Interventions: DIAGNOSTIC_TEST: Brief Negative Symptoms Scale|DIAGNOSTIC_TEST: The Calgary Depression Scale for Schizophrenia|DIAGNOSTIC_TEST: The Schizophrenia Cognition Rating Scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Use of a Connected Pillbox On Medication Adherence
Status: COMPLETED
Conditions: Diabetes Mellitus|Hypertension|Hyperlipidemia
Interventions: DEVICE: Pre-filled trays
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dental Restorations Effect on Oxidative Status of the Gingival Crevicular Fluid
Status: COMPLETED
Conditions: Pharmacological Action
Interventions: PROCEDURE: Amalgam placement|PROCEDURE: Tetric EvoCeram placement|PROCEDURE: Beautifil placement|PROCEDURE: Zinc phosphate cement placement|PROCEDURE: Zinc polycarboxylate cement placement|PROCEDURE: Glass ionomer cement placement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparative Study of the Contraceptive Efficacy of the Cupid, Cupid 2 and FC2 Female Condom
Status: COMPLETED
Conditions: Pregnancy Prevention
Interventions: DEVICE: FC2 Condom|DEVICE: Cupid Condom|DEVICE: Cupid 2 Condom
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Oral GS-6615 on Dofetilide-Induced QT Prolongation, Safety, and Tolerability in Healthy Adults
Status: COMPLETED
Conditions: Long QT Syndrome
Interventions: DRUG: GS-6615|DRUG: Placebo to match GS-6615|DRUG: Placebo to match dofetilide|DRUG: Dofetilide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Sudy Comparing Argatroban® IV vs Desirudin SC for Suspected HIT With or Without Thrombosis Syndrome
Status: TERMINATED
Conditions: Suspected Heparin-Induced Thrombocytopenia
Interventions: DRUG: Desirudin or Argatroban®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Diagnosis of Mediastinal Tuberculous Lymphadenopathy by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA)
Status: UNKNOWN
Conditions: Mediastinal Lymphadenopathy|Tuberculous Mediastinal Lymphadenopathy
Interventions: PROCEDURE: endobronchial ultrasound-guided transbronchial needle aspiration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of a Balance Reeducation Protocol on Pain, Function and Postural Control of Low Back Pain Patients
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: General exercise only|OTHER: Balance reeducation plus general exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy of Oral Sacubitril/Valsartan in Adult Patients With Non-obstructive Hypertrophic Cardiomyopathy
Status: COMPLETED
Conditions: Cardiomyopathy, Hypertrophic
Interventions: DRUG: LCZ696|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-center, Randomized, Subject Blind, Active Controlled Design Clinical Study to Evaluate the Efficacy and Safety of Volus as Compared to PowerFill® for Temporary Penile Enhancement
Status: COMPLETED
Conditions: Penile Enhancement
Interventions: DEVICE: Volus/Powerfill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: GAMMA Study: Patient Self-testing of Capillary Blood Potassium: A Validation Study and Measurement Performance in Patients.
Status: RECRUITING
Conditions: Potassium Measurement
Interventions: DEVICE: Device: Self testing Potassium device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bioequivalence Study of Torrent Pharmaceutical Ltd's Esomeprazole Magnesium Delayed Release Capsules
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Nexium 40 mg DR Capsules of AstraZeneca LP, USA|DRUG: Torrent's Esomeprazole Magnesium DR Capsules 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-Guided Photodynamic Therapy With Photofrin & Gemcitabine for Patients With Locally Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Acinar Cell Adenocarcinoma of the Pancreas|Duct Cell Adenocarcinoma of the Pancreas|Stage III Pancreatic Cancer
Interventions: DRUG: porfimer sodium|PROCEDURE: endoscopic ultrasonography|PROCEDURE: photodynamic therapy|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of Vinflunine Plus Methotrexate Versus Methotrexate Alone in Patients With Head and Neck Cancer
Status: COMPLETED
Conditions: Recurrent or Metastatic Head and Neck Carcinoma
Interventions: DRUG: Vinflunine|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Accuracy of the OptoWire DeuxTM in a Wire to Wire Comparison
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Stenosis|Atherosclerosis|Atherosclerosis, Coronary|Angina, Stable|Angina, Unstable|NSTEMI - Non-ST Segment Elevation MI
Interventions: DEVICE: Drift assessment of OptoWire Deux FFR wire (1)|DEVICE: Drift assessment of OptoWire Deux FFR wire (2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination Chemotherapy in Treating Patients With Stage II or Stage III Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: idarubicin|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of CCI-779 (Temsirolimus) in Combination With Topotecan in Patients With Gynecologic Malignancies
Status: COMPLETED
Conditions: Genital Neoplasms, Female
Interventions: DRUG: Topotecan|DRUG: CCI-779 (temsirolimus)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial of Fisetin in Healthy Volunteers and Older Patients With Multimorbidity
Status: NOT_YET_RECRUITING
Conditions: Multimorbidity|Healthy
Interventions: DRUG: Fisetin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Registry to Assess the Safety and Feasibility of the Subpulmonary Support With the Novel Venous Cannula in Patients With Failing/Absence of the Right Heart
Status: RECRUITING
Conditions: Heart Failure|Univentricular Heart|Ventricular Dysfunction|Heart Diseases|Cardiovascular Diseases
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Combination Treatment With MabThera (Rituximab) and RoActemra (Tocilizumab) Versus RoActemra in Patients With Rheumatoid Arthritis With an Incomplete Response to Methotrexate
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Placebo|DRUG: rituximab [MabThera/Rituxan]|DRUG: tocilizumab [RoActemra/Actemra]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ex Vivo Study of the Heracure Device for Intra-uterine Morcellation After Vaginal or Laparoscopic Hysterectomy
Status: UNKNOWN
Conditions: Vaginal or Laparoscopic Hysterectomy
Interventions: DEVICE: Heracure Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Evaluation of POC Pulse-dose Demand Oxygen Delivery for Nocturnal Hypoxemia
Status: COMPLETED
Conditions: Nocturnal Hypoxemia
Interventions: DEVICE: InogenOne Rove 6 Portable Oxygen Concentrator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing PEG 3350 Laxative to Placebo in the Treatment of Occasional Constipation (Study CL2007-12)(P08216)
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: Polyethylene glycol 3350|OTHER: Placebo, maltodextrin 500 powder for solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarker Guided Discharge of Heart Failure Patients
Status: RECRUITING
Conditions: Heart Failure; With Decompensation
Interventions: OTHER: Biomarker guided discharge algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of SCM-CGH in Patients With Steroid-Refractory or Dependent Chronic Graft-Versus-Host Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Graft-versus-host-disease
Interventions: BIOLOGICAL: SCM-CGH|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Stage II, Stage III, or Stage IV Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: carboplatin|DRUG: paclitaxel|DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine in Post Spinal Anesthesia Shivering
Status: COMPLETED
Conditions: Shivering Caused by Spinal Anesthesia
Interventions: DRUG: Pethidine 0.4mg/kg|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Develop a Prediction Model to Understand the Effect of Low-dose Aspirin on Cancer That Develops in the Colon and/or the Rectum, Diseases That Affects the Heart or Blood Vessels and Safety Outcomes in European Countries. The Study is Also Called PEACOS Model EU
Status: COMPLETED
Conditions: Colorectal Cancer|Cardiovascular Disease|Bleeding
Interventions: DRUG: Acetylsalicylic Acid (Aspirin, BAYE4465)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: BI836826 Dose Escalation in Relapsed Chronic Lymphocytic Leukaemia (CLL)
Status: COMPLETED
Conditions: Leukemia, Lymphocytic, Chronic, B-Cell
Interventions: DRUG: BI 836826
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improvement of Endothelial Function by EGCG
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DIETARY_SUPPLEMENT: Green tea beverage|DIETARY_SUPPLEMENT: Green tea extract|DIETARY_SUPPLEMENT: EGCG|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Root Planing on Surface Topography.
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: DEVICE: conventional gracey curettes|DEVICE: Vertically oscillating ultrasonic device|DEVICE: piezoelectric ultrasonic scraper
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Follow-up of Prader Willi Syndrome Infants Treated by Oxytocin and Comparison With Not-treated Infants.
Status: COMPLETED
Conditions: Prader-Willi Syndrome
Interventions: DRUG: Oxytocin|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Endodontic Treatment on Inflammatory Markers, Disease Activity and Periapical Healing in Rheumatoid Arthritis Patients With Apical Periodontitis : A Prospective Interventional Study
Status: RECRUITING
Conditions: Rheumatoid Arthritis AND Apical Periodontitis
Interventions: PROCEDURE: ROOT CANAL TREATMENT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation-free Bone Imaging UTE MRI in Healthy and Diseased Patients
Status: COMPLETED
Conditions: Bone Anatomy|Bone Diseases
Interventions: DIAGNOSTIC_TEST: Acquiring of ultrashort echo time (UTE) MRI sequences
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Novel Cognitive Remediation Intervention Targeting Poor Decision-making and Depression in Veterans at High Risk for Suicide: A Safe, Telehealth Approach During the COVID-19 Pandemic
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: OTHER: Neuropsychological Educational Approach to Cognitive Remediation (NEAR, termed Cognitive Remediation plus Bridging)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Systemic Vascular Endothelial Growth Factor (VEGF) Protein Dynamics Following Intravitreal Injections of Ranibizumab Versus Aflibercept in Patients With Neovascular Age-related Macular Degeneration
Status: COMPLETED
Conditions: Wet Age-Related Macular Degeneration
Interventions: DRUG: Ranibizumab 0.5 mg|DRUG: Aflibercept 2 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacoeconomic Study Assessing the Cost of Chronic Hepatitis C Treatment With Peginterferon Alfa-2b (PegIntron) and Ribavirin (Rebetol) in the Czech Republic (Study P04588)(COMPLETED)
Status: COMPLETED
Conditions: Hepatitis C, Chronic|Hepatitis C
Interventions: BIOLOGICAL: peginterferon alfa-2b|DRUG: ribavirin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Quality of Life After Vertebroplasty Versus Conservative Treatment in Patients With Painful Osteoporotic Vertebral Fractures
Status: COMPLETED
Conditions: Spinal Fracture|Osteoporosis|Back Pain
Interventions: PROCEDURE: percutaneous injection of cement into the vertebral body|OTHER: Medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety of Intravitreal APL-2 in Patients Diagnosed With Geographic Atrophy
Status: COMPLETED
Conditions: Geographic Atrophy
Interventions: DRUG: PEGCETACOPLAN (APL-2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplementation of Polyunsaturated Fatty Acids in Children With Attention Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: ADHD
Interventions: DIETARY_SUPPLEMENT: Eye Q
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics of BMS-986141 in Participants With Hepatic Impairment Compared to Healthy Participants
Status: WITHDRAWN
Conditions: Hepatic Impairment
Interventions: DRUG: BMS-986141
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT