pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: An Efficacy and Safety Study of Daratumumab in Patients With Multiple Myeloma Who Have Received at Least 3 Prior Lines of Therapy (Including a Proteasome Inhibitor [PI] and Immunomodulatory Drug [IMiD]) or Are Double Refractory to a PI and an IMiD
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Daratumumab 16 mg/kg (Part 1)|DRUG: Daratumumab 8 mg/kg (Part 1)|DRUG: Methylprednisolone|DRUG: Acetaminophen|DRUG: Diphenhydramine|DRUG: Daratumumab (Part 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gevokizumab With Standard of Care Anti-cancer Therapies for Metastatic Colorectal, Gastroesophageal, and Renal Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer|Gastroesophageal Cancer|Renal Cell Carcinoma
Interventions: DRUG: Gevokizumab|DRUG: Bevacizumab|DRUG: Modified FOLFOX6|DRUG: FOLFIRI|DRUG: Ramucirumab|DRUG: Paclitaxel|DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy and Safety of Intravitreal (IVT) Aflibercept for the Improvement of Moderately Severe to Severe Nonproliferative Diabetic Retinopathy (NPDR)
Status: COMPLETED
Conditions: Nonproliferative Diabetic Retinopathy
Interventions: DRUG: Intravitreal aflibercept injection [IAI]|DRUG: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Of Advanced Gastrointestinal Malignancies And Other Solid Tumors
Status: COMPLETED
Conditions: Advanced Gastrointestinal Malignancies|Solid Tumors
Interventions: DRUG: Oxaliplatin|DRUG: Gemcitabine|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of Perioperative Chemotherapy Plus Immunotherapy Followed by Surgery in Localized Esophageal and Gastroesophageal Adenocarcinoma
Status: RECRUITING
Conditions: Clinical Stage II Esophageal Adenocarcinoma AJCC v8|Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8|Clinical Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IIB Esophageal Adenocarcinoma AJCC v8|Clinical Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage III Esophageal Adenocarcinoma AJCC v8|Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IB Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IB Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IC Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IC Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage II Esophageal Adenocarcinoma AJCC v8|Pathologic Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIA Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIB Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage III Esophageal Adenocarcinoma AJCC v8|Pathologic Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8
Interventions: DRUG: Atezolizumab|PROCEDURE: Conventional Surgery|DRUG: Fluorouracil|DRUG: Oxaliplatin|DRUG: Tiragolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of 'Parentbot - a Digital Healthcare Assistant (PDA)' in Improving Parenting Outcomes During the Perinatal Period
Status: COMPLETED
Conditions: Perinatal Depression|Parents|Self Efficacy|Anxiety|Stress|Parenting Satisfaction
Interventions: BEHAVIORAL: PDA mobile application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Examining Neurobiological Mechanisms Underlying the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder (BD)
Status: RECRUITING
Conditions: Bipolar Disorder
Interventions: OTHER: Non-ketogenic Diet|OTHER: Ketogenic Diet|OTHER: No diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mesenchymal Stem Cells for Idiopathic Dilated Cardiomyopathy
Status: UNKNOWN
Conditions: Primary Idiopathic Dilated Cardiomyopathy
Interventions: OTHER: bone marrow-derived MSCs injection|OTHER: placebo intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of JNJ-32729463 Compared With Moxifloxacin for the Treatment of Subjects Requiring Hospitalization for Community-Acquired Bacterial Pneumonia
Status: TERMINATED
Conditions: Community-Acquired Bacterial Pneumonia (CABP)
Interventions: DRUG: JNJ-32729463|DRUG: moxifloxacin|DRUG: JNJ-32729463 (Open-Label)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Clinical Trial to Evaluate the Human Norovirus Bivalent (GⅠ.1/GⅡ.4)Vaccine，Recombinant (Hansenula Polymorpha)
Status: NOT_YET_RECRUITING
Conditions: Norovirus Infections|Norwalk Gastroenteritis
Interventions: BIOLOGICAL: Human Norovirus Bivalent (GⅠ.1/GⅡ.4)Vaccine，Recombinant (Hansenula polymorpha)|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: COVID-19 Related Lockdown Effects On Chronic Diseases
Status: UNKNOWN
Conditions: Chronic Coronary Syndrome|Heart Failure|AMD and Macular Edema|Chronic Respiratory Failure|Hemophilia|Malignant Hemopathy|Multiple Sclerosis|Horton's Disease
Interventions: OTHER: life questionnaires|OTHER: questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Modified Pedicle Subepithelial Connective Tissue Graft for Interdental Papillary Reconstruction Around Delayed Implants in the Esthetic Zone: A Case Series Trail
Status: UNKNOWN
Conditions: Papilla Reconstruction
Interventions: PROCEDURE: papilla reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the "Appui Parental": A Program of Early Support to Parenthood
Status: COMPLETED
Conditions: Infant Development
Interventions: BEHAVIORAL: "Appui Parental" program|BEHAVIORAL: Regular parental support
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Long Term Extension Study for the Maintenance Treatment of Anemia Associated With Chronic Kidney Disease (CKD) in Hemodialysis Subjects on Epoetin Alfa / Beta Treatment Versus BAY85-3934
Status: COMPLETED
Conditions: Anemia|Renal Insufficiency, Chronic
Interventions: DRUG: Molidustat (BAY85-3934)|BIOLOGICAL: Epoetin alfa/beta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel, Ifosfamide and Cisplatin (TIP) Versus Bleomycin, Etoposide and Cisplatin (BEP) for Patients With Previously Untreated Intermediate- and Poor-risk Germ Cell Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Germ Cell Tumors
Interventions: DRUG: Paclitaxel|DRUG: Ifosfamide|DRUG: Cisplatin|DRUG: Mesna|DRUG: Bleomycin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TQH2722 Injection to Evaluate the Safety, Tolerability, Pharmacokinetics, Efficacy and Immunogenicity in Healthy Adult Subjects
Status: UNKNOWN
Conditions: Atopic Dermatitis
Interventions: DRUG: TQH2722 injection|DRUG: Placebo to match TQH2722
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Propranolol Hydrochloride and Chemotherapy in Treating Patients With Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
Status: COMPLETED
Conditions: Fallopian Tube Clear Cell Adenocarcinoma|Fallopian Tube Endometrioid Adenocarcinoma|Fallopian Tube Mucinous Adenocarcinoma|Fallopian Tube Serous Adenocarcinoma|Fallopian Tube Undifferentiated Carcinoma|Ovarian Clear Cell Adenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Mucinous Adenocarcinoma|Ovarian Seromucinous Carcinoma|Ovarian Serous Adenocarcinoma|Ovarian Undifferentiated Carcinoma|Primary Peritoneal Serous Adenocarcinoma|Stage II Fallopian Tube Cancer AJCC v6 and v7|Stage II Ovarian Cancer AJCC v6 and v7|Stage IIA Fallopian Tube Cancer AJCC v6 and v7|Stage IIA Ovarian Cancer AJCC V6 and v7|Stage IIB Fallopian Tube Cancer AJCC v6 and v7|Stage IIB Ovarian Cancer AJCC v6 and v7|Stage IIC Fallopian Tube Cancer AJCC v6 and v7|Stage IIC Ovarian Cancer AJCC v6 and v7|Stage III Fallopian Tube Cancer AJCC v7|Stage III Ovarian Cancer AJCC v6 and v7|Stage III Primary Peritoneal Cancer AJCC v7|Stage IIIA Fallopian Tube Cancer AJCC v7|Stage IIIA Ovarian Cancer AJCC v6 and v7|Stage IIIA Primary Peritoneal Cancer AJCC v7|Stage IIIB Fallopian Tube Cancer AJCC v7|Stage IIIB Ovarian Cancer AJCC v6 and v7|Stage IIIB Primary Peritoneal Cancer AJCC v7|Stage IIIC Fallopian Tube Cancer AJCC v7|Stage IIIC Ovarian Cancer AJCC v6 and v7|Stage IIIC Primary Peritoneal Cancer AJCC v7|Stage IV Fallopian Tube Cancer AJCC v6 and v7|Stage IV Ovarian Cancer AJCC v6 and v7|Stage IV Primary Peritoneal Cancer AJCC v7
Interventions: DRUG: Chemotherapy|DRUG: Propranolol Hydrochloride|OTHER: Quality-of-Life Assessment|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Naltrexone Versus Placebo to Reduce Craving for Alcohol With Evaluation of Genetic Variability.
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: Naltrexone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PDR001 in Patients With Non-small Cell Lung Cancer Harboring KRAS/NRAS Mutation or no Actionable Genetic Abnormalities
Status: UNKNOWN
Conditions: Cancer|Lung Cancer Metastatic|Immunotherapy
Interventions: DRUG: PDR001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Proof of Concept Study Assessing the Effect of Four Different Single Bolus Intravenous Doses of FE200440 and Placebo on Stopping Preterm Labor
Status: COMPLETED
Conditions: Labor, Premature|Premature Birth
Interventions: DRUG: FE200440
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Understanding Ayurveda Disease Conditions and Treatment Responses
Status: COMPLETED
Conditions: Type2diabetes|Rheumatoid Arthritis|Osteo Arthritis Knee|Skin Diseases|Gastric Ulcer|Neurodegenerative Diseases
Interventions: DRUG: Personalized Ayurveda treatment protocol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Autologous Platelet-rich Plasma for Clomiphene Citrate-induced Thin Endometrium
Status: COMPLETED
Conditions: Infertility, Female, Associated With Anovulation
Interventions: DRUG: clomiphene citrate|DRUG: Saline cervical flushing|BIOLOGICAL: Intrauterine Autologous platelet-rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Behavioural Interventions for Postnatal Depression: a RCT Study
Status: COMPLETED
Conditions: Postnatal Depression
Interventions: BEHAVIORAL: Brief Cognitive Behavioral Therapy|BEHAVIORAL: standard management based on Clinical Practice Guideline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Valproate Versus Propranolol in Migraine
Status: RECRUITING
Conditions: Migraine Disorders
Interventions: DRUG: Valproic Acid 500 MG|DRUG: Propranolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Activity of ISIS 113715 in People With Type 2 Diabetes Mellitus Being Treated With Sulfonylurea
Status: WITHDRAWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: ISIS 113715
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Crofelemer for Functional Diarrhea
Status: TERMINATED
Conditions: Diarrhea
Interventions: DRUG: Crofelemer|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Noradrenergic Add-on Therapy With Guanfacine
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: Guanfacine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Subcutaneous Single and Multiple Ascending Dose Study of BG00010 (Neublastin)
Status: COMPLETED
Conditions: Painful Lumbar Radiculopathy|Healthy
Interventions: BIOLOGICAL: BG00010 IV|BIOLOGICAL: BG00010 SC|DRUG: Placebo IV|DRUG: Placebo SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Beetroot Juice Ingestion on Female Rugby Performance
Status: COMPLETED
Conditions: Nitric Oxide|Placebo
Interventions: DIETARY_SUPPLEMENT: Beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Ranibizumab (Lucentis®) for Neovascular Glaucoma- a Randomized Controlled Study
Status: UNKNOWN
Conditions: Glaucoma, Neovascular|Ranibizumab
Interventions: DRUG: Intravitreal ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Performance of SYMATESE AESTHETICS ESTYME® MATRIX Round Microtextured Silicone Gel-Filled Breast Implants in the Breast Augmentation
Status: ACTIVE_NOT_RECRUITING
Conditions: Bilateral Breast Augmentation
Interventions: DEVICE: ESTYME® MATRIX Round Microtextured Silicone Gel-Filled Breast Implants
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pre-pectoral Breast Reconstruction PART 2
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DEVICE: Two-stage with Acellular Dermal Matrix (CELLIS® Breast)|DEVICE: Two-stage with Titanium Coated Polypropylene Mesh (TiLOOOP® Bra)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Behavioral Change Communication (BCC) to Promote Physical Activity Among Females With Type 2 Diabetes Mellitus Attending Diabetic Clinic
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Behavioral change communication to promote physical activity|BEHAVIORAL: Behavioral change communication to promote physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: the Study of the Association Between the Gut Microbiota and Central Serous Chorioretinopathy
Status: RECRUITING
Conditions: Central Serous Chorioretinopathy
Interventions: DIETARY_SUPPLEMENT: Live Combined Bifidobacterium|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Psilocybin-facilitated Treatment for Cocaine Use
Status: COMPLETED
Conditions: Cocaine-Related Disorders
Interventions: DRUG: Psilocybin|DRUG: Diphenhydramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Conversion Therapy of RAS/BRAF Wild-Type Right-sided Colon Cancer Patients With Initially Unresectable Liver Metastases
Status: UNKNOWN
Conditions: Colorectal Cancer|Liver Metastases
Interventions: DRUG: Cetuximab|DRUG: Bevacizumab|DRUG: mFOLFOX/FOLFIRI ( Standard Chemotherapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does the Use of Bupivacaine Soaked Vaginal Packing Following Vaginal Surgery Decrease Postoperative Pain?
Status: COMPLETED
Conditions: Pelvic Organ Prolapse|Postoperative Pain
Interventions: DRUG: Bupivacaine|DRUG: Premarin Vaginal cream
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of a Tonometer to Identify Epileptogenic Lesions During Pediatric Epilepsy Surgery
Status: WITHDRAWN
Conditions: Epilepsy|Focal Cortical Dysplasia|Tuberous Sclerosis|Hemimegalencephaly|Polymicrogyria|Rasmussen Encephalitis|Sturge-Weber Syndrome|Gliosis|Stroke|Tumor, Brain
Interventions: DEVICE: Intra-operative brain tonometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Simvastatin and Ezetimibe on Cardiovascular Risk Markers in Patients With Dyslipidemia
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: Simvastatin|DRUG: Ezetimibe|DRUG: Simvastatin + Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ADAGiO: Adoptive Cellular Therapy for the TreAtment of Recurrent OliGodendrogliOma (OG) Adult Patients
Status: NOT_YET_RECRUITING
Conditions: Recurrent Oligodendroglioma|Progressive Oligodendroglioma
Interventions: BIOLOGICAL: TTRNA-DC vaccines with GM-CSF|BIOLOGICAL: Autologous Hematopoietic Stem cells (HSCs)|BIOLOGICAL: TTRNA-xALT|DRUG: Td vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a Commercially Available Influenza Vaccine (Formulation 2007/2008) When Administered to NON Elderly AND Elderly Subjects
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Surface Antigen, Inactivated, Adjuvanted, Influenza Vaccine, Formulation 2007-2008
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Unrelated Umbilical Cord Blood Transplantation With Coinfusion of Mesenchymal Stem Cells
Status: COMPLETED
Conditions: Allogeneic Stem Cell Transplantation
Interventions: OTHER: cord blood transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tividenofusp Alfa (DNL310) in Pediatric Participants With Hunter Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Mucopolysaccharidosis II
Interventions: DRUG: tividenofusp alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of a Recombinant Factor IX in Patients With Severe Hemophilia B
Status: COMPLETED
Conditions: Hemophilia B
Interventions: BIOLOGICAL: Recombinant Coagulation Factor IX Albumin Fusion Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Prexasertib (LY2606368) in Participants With Advanced Cancer
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DRUG: [¹⁴C]Prexasertib|DRUG: Prexasertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Budesonide for Liver Transplant Immune Suppression
Status: COMPLETED
Conditions: Acute Cellular Graft Rejection|New Onset Diabetes After Transplant
Interventions: DRUG: Budesonide 3Mg Capsule|DRUG: Standard of Care Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Milk Versus a Pea-based Beverage for Bone and Muscle Health in Young Athletes
Status: COMPLETED
Conditions: Muscle Atrophy
Interventions: DIETARY_SUPPLEMENT: Nutritional supplementation during a 6 month resistance training program|DIETARY_SUPPLEMENT: Nutritional supplementation during a 6 month resistance training program|DIETARY_SUPPLEMENT: Nutritional supplementation during a 6 month resistance training program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Combination Chemotherapy in Treating Patients With Stage III or Stage IV Ovarian Epithelial or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: carboplatin|DRUG: paclitaxel|DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: TreatPaCS = Treatment for Preschool Age Children Who Stutter
Status: RECRUITING
Conditions: Stuttering, Developmental
Interventions: BEHAVIORAL: Lidcombe Program|BEHAVIORAL: Mini-KIDS|BEHAVIORAL: Social Cognitive Behavioural Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Etoposide, Prednisone, Vincristine Sulfate, Cyclophosphamide, and Doxorubicin Hydrochloride With Asparaginase in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma
Status: WITHDRAWN
Conditions: B Acute Lymphoblastic Leukemia|B Lymphoblastic Lymphoma|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent B Lymphoblastic Lymphoma|Recurrent T Lymphoblastic Leukemia/Lymphoma|Refractory B Lymphoblastic Lymphoma|Refractory T Lymphoblastic Lymphoma|T Acute Lymphoblastic Leukemia|T Lymphoblastic Lymphoma
Interventions: DRUG: Asparaginase|DRUG: Cyclophosphamide|DRUG: Doxorubicin Hydrochloride|DRUG: Etoposide|DRUG: Imatinib Mesylate|OTHER: Laboratory Biomarker Analysis|DRUG: Prednisone|BIOLOGICAL: Rituximab|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of Chemo-Immunotherapy Combination in Melanoma Patients
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: Melan-A|OTHER: Melan-A plus Dacarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dose Ascorbate With Preoperative Radiation in Patients With Locally Advanced Soft Tissue Sarcomas
Status: COMPLETED
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: Ascorbate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dolutegravir Antiretroviral Strategy to Promote Improvement and Reduce Drug Exposure
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: dolutegravir|DRUG: lamivudine|DRUG: Continue current antiretroviral regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Global Coagulation Assessment in Portal Vein Thrombosis and Budd-Chiari Syndrome
Status: RECRUITING
Conditions: Hepatic Vein Thromboses|Hepatic Venous Outflow Obstruction|Portal Vein Thrombosis|Portal Hypertension, Noncirrhotic|Portal Vein Occlusion|Portal Vein Embolism|JAK2 Mutation|CALR Gene Mutation|Prothrombin G20210A|Anticoagulants and Bleeding Disorders
Interventions: DIAGNOSTIC_TEST: Rotational thromboelastometry|DIAGNOSTIC_TEST: Genetic tests for Thrombophilia|DIAGNOSTIC_TEST: ELISA tests/ Functional assays
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparing the Efficacy and Safety of NN1250 Once Daily When Titrated Using 2 Different Algorithms in Insulin naïve Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec|DRUG: insulin degludec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Radiation Therapy and Vismodegib for Advanced Head/Neck Basal Cell Carcinoma
Status: COMPLETED
Conditions: Locally Advanced Basal Cell Carcinoma|Skin Cancer|Cutaneous Malignancy
Interventions: DRUG: Vismodegib|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Tranexamic Acid When Used as an Adjunct to Misoprostol for the Treatment of Postpartum Hemorrhage
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Tranexamic Acid|DRUG: Placebo|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RNS System LGS Feasibility Study
Status: RECRUITING
Conditions: Epilepsy|Lennox Gastaut Syndrome|Lennox-Gastaut Syndrome, Intractable|Seizures|Seizures, Generalized
Interventions: DEVICE: RNS System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and B-memory Cell Response to QHPV Vaccine 9-years Post-vaccination Among HIV-infected Boys and Girls
Status: UNKNOWN
Conditions: HPV-Related Carcinoma
Interventions: DRUG: Quadrivalent HPV [Type 6, 11, 16 and 18] L1 Virus-Like Particle Vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating Metabolic Mechanisms of Ertugliflozin in Diabetes & Heart Failure
Status: TERMINATED
Conditions: Heart Failure, Diastolic|Diabetes Mellitus, Type 2
Interventions: DRUG: Ertugliflozin 5 mg|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Sofosbuvir Plus Daclatasvir With or Without Ribavirin and Chronic HCV Genotype (GT) 4
Status: COMPLETED
Conditions: Chronic Hepatitis C Virus Infection
Interventions: DRUG: (SOF and DCV)|DRUG: (SOF, DCV, and RBV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Emergency On-call Respiratory Physiotherapy Services in the Paediatric Intensive Care Unit
Status: COMPLETED
Conditions: Pediatrics|Critical Care|Respiration, Artificial
Interventions: OTHER: Airway clearance intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Exploratory Clinical Study to Evaluate the Safety and Efficacy of NK Cells (Combined With Standard Therapy) in the Treatment of Solid Tumor Patients
Status: WITHDRAWN
Conditions: Solid Tumors (Pancreatic Cancer, Esophageal Cancer, Gastric Cancer, Cholangiocarcinoma, Lung Cancer and Ovarian Cancer)
Interventions: DRUG: Allogeneic NK（CCT-ANK-11)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Weekly High-dose Vitamin D3 Supplementation on the Association Between Circulatory FGF-23 and A1c Levels
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Kidney Diseases
Interventions: DIETARY_SUPPLEMENT: Soft gelatin capsules each contains 50 000 IU VD3 (cholecalciferol) equivalents to 1.25 mg.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics of Suvorexant in Participants With Hepatic Insufficiency (MK-4305-017)
Status: COMPLETED
Conditions: Insomnia|Hepatic Insufficiency
Interventions: DRUG: Suvorexant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Utility of Remote Index of Microvascular Resistance in Patients With Chronic Total Occlusion
Status: COMPLETED
Conditions: Chronic Total Occlusion
Interventions: OTHER: Directly measure microvascular function using direct coronary flow measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Evaluation of Low Sodium Peritoneal Dialysis (PD) Solution on Hypertensive Patients Treated With PD
Status: COMPLETED
Conditions: Chronic Kidney Failure
Interventions: DRUG: Solution for Peritoneal Dialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Personalized Rendering of Motor System Functional Plasticity Potential to Improve Glioma Resection and Quality of Life
Status: RECRUITING
Conditions: Glioma|Glioma, Malignant
Interventions: DIAGNOSTIC_TEST: Resting State Functional Magnetic Resonance Imaging (rs-fMRI)|BEHAVIORAL: Up-front Motor Rehabilitation|DRUG: Up-front Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy at 24 Weeks and Long Term Safety, Tolerability and Efficacy up to 2 Years of Secukinumab (AIN457) in Patients With Active Psoriatic Arthritis (PsA)
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Secukinumab (75 mg)|DRUG: Secukinumab (150 mg)|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Standard Patient Training Versus Vik Chatbot Guided Training: a Randomized Controlled Trial for Asthma Patients
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: Standard patient education|OTHER: Chatbot patient education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Efficacy and Safety Study of Sevelamer Carbonate in Hyperphosphatemic Pediatric Participants With Chronic Kidney Disease
Status: COMPLETED
Conditions: Hyperphosphatemia|Chronic Kidney Disease
Interventions: DRUG: Placebo|DRUG: Sevelamer carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sensorimotor Rehabilitation Program in Improving Quality of Life in Patients With Early Stage Breast Cancer
Status: COMPLETED
Conditions: Peripheral Neuropathy|Stage I Breast Cancer AJCC v7|Stage IA Breast Cancer AJCC v7|Stage IB Breast Cancer AJCC v7|Stage II Breast Cancer AJCC v6 and v7|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7
Interventions: OTHER: Educational Intervention|BEHAVIORAL: Exercise Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: UTAA17 Injection in the Treatment of Relapsed/Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Relapsed/Refractory Multiple Myeloma
Interventions: BIOLOGICAL: UTAA17 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial in Metastatic Colorectal Cancer With FOLFIRI Plus Aflibercept as First Line Treatment
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: 5 Fluorouracil|DRUG: Leucovorin|DRUG: Irinotecan|DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sickness Evaluation at Altitude With Acetazolamide at Relative Dosages
Status: COMPLETED
Conditions: Acute Mountain Sickness
Interventions: DRUG: Acetazolamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prostate Magnetic Resonance Imaging in Patient With Previous Negative Biopsies
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DEVICE: 3T multiparametric MRI|DEVICE: Transrectal ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Quadratus Lumborum Block Versus Fascia Iliaca Block for Hip Arthroplasty
Status: UNKNOWN
Conditions: Post Operative Pain
Interventions: PROCEDURE: quadratus lumborum block; (Anterior QLB or QLB III)|PROCEDURE: suprainguinal fascia iliaca block|PROCEDURE: Subarachnoid block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injections for Post-Operative Pain Following Colorectal Surgery
Status: COMPLETED
Conditions: Post-Operative Pain
Interventions: DRUG: VVZ-149 Injections|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Promoting Activity and Cognitive Enrichment in Schizophrenia (PACES)
Status: RECRUITING
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Cognitive Enhancement Therapy|BEHAVIORAL: Enriched Supportive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1b of ASLAN001 (Varlitinib) in Patients With Advanced/ Metastatic Hepatocellular Carcinoma (HCC)
Status: UNKNOWN
Conditions: Advanced/ Metastatic Hepatocellular Carcinoma
Interventions: DRUG: ASLAN001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Sugar Load in IBS Patients Depending on Sucrase-isomaltase Genes
Status: ENROLLING_BY_INVITATION
Conditions: Sucrase-Isomaltase Deficiency|Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Sugar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Behavioural Economics-based Incentives in Adults With Type 2 Diabetes (BET2)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Financial and social incentives|BEHAVIORAL: Financial incentives
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Efficacy of a Brief Mindfulness-Based Intervention SMOKING INTERVENTION VIA THE INTERNET
Status: COMPLETED
Conditions: Substance Use|Smoking Reduction
Interventions: BEHAVIORAL: Mindfulness Intervention|BEHAVIORAL: Control Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intramyocardial Injection of Autologous UCB-MNC During Fontan Surgery for SRV Dependent CHD
Status: ACTIVE_NOT_RECRUITING
Conditions: Congenital Heart Disease, SRV Dependent
Interventions: BIOLOGICAL: Autologous mononuclear cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202)
Status: RECRUITING
Conditions: Severe Aplastic Anemia
Interventions: DRUG: cyclosporine|PROCEDURE: Matched Unrelated Donor Hematopoetic Stem Cell Transplant|DRUG: horse anti-thymocyte globulin (ATG)|DRUG: rabbit anti-thymocyte globulin (ATG)|DRUG: Methotrexate|DRUG: Fludarabine|DRUG: Cyclophosphamide|RADIATION: low-dose total body irradiation (TBI)|PROCEDURE: Immunosuppressive Therapy (IST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CKD Specific Telemonitoring Platform to Minimize Adverse Outcomes in High Risk CKD Patients
Status: RECRUITING
Conditions: Chronic Kidney Disease Stage 5|End Stage Renal Disease
Interventions: DEVICE: VIEWER virtual care platform
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of TKI 258 in Combination With Xeloda and Oxaliplatin in Advanced Colorectal and Gastric Cancer
Status: TERMINATED
Conditions: Colorectal Cancer|Gastric Cancer
Interventions: DRUG: Xeloda,|DRUG: Oxaliplatin|DRUG: TKI258
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyaluronidase Via LADD Scleroderma-induced Microstomia
Status: RECRUITING
Conditions: Microstomia|Scleroderma
Interventions: DRUG: Hyaluronidase|DEVICE: co2 laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genotypic Resistance Guided Therapy for Refractory H. Pylori Infection
Status: UNKNOWN
Conditions: H Pylori Infection
Interventions: DRUG: Esomeprazole 40mg|DRUG: Amoxicillin|DRUG: metronidazole|DRUG: Levofloxacin 500mg|DRUG: Clarithromycin ER|DRUG: Esomeprazole 40mg|DRUG: Dibismuth trioxide|DRUG: metronidazole|DRUG: tetracycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiac Output Monitoring by Transpulmonary Thermodilution and Transthoracic Echocardiography in Critically Ill Patients
Status: COMPLETED
Conditions: Sinus Rhythm
Interventions: OTHER: Cardiac output measurement by transpulmonary thermodilution and transthoracic echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Cell Membrane Expression of Annexin A2 on Monocytes by Flow Cytometry in Primary Antiphospholipid Syndrome
Status: RECRUITING
Conditions: Antiphospholipid Syndrome
Interventions: BIOLOGICAL: blood withdrawal
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of the Safety and Effectiveness of Topiramate on Insulin Sensitivity in Overweight or Obese Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Obesity|Diabetes Mellitus, Type 2|Diabetes Mellitus, Adult-Onset
Interventions: DRUG: topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of NXY-059 for the Treatment of Patients Who Have Suffered From a Stroke
Status: COMPLETED
Conditions: Cerebral Stroke|Ischemic Attack, Transient
Interventions: DRUG: NXY-059
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Spinal Mobilization on Respiratory Parameters in Parkinson's Disease Patients
Status: RECRUITING
Conditions: Parkinson Disease|Camptocormia|Restrictive Lung Disease
Interventions: OTHER: Diaphragmatic stimulation treatment with PNF techniques|OTHER: Costal mobilization|OTHER: Breathing exercises|OTHER: Spinal mobilization|OTHER: Sham mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Cost Effectiveness of Brief Cognitive-Behavioral Therapy (CBT) for Pediatric Internalizing Disorders
Status: COMPLETED
Conditions: Depression|Anxiety
Interventions: BEHAVIORAL: BCBT|BEHAVIORAL: SMHC referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Systematic Implementation of Patient-centered Care for Alcohol Use Trial: Beyond Referral to Treatment
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder|Unhealthy Alcohol Use
Interventions: BEHAVIORAL: Centralized Intervention|OTHER: Primary Care Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Correlation Between Preoperative Refraction and Anterior Segment Parameters With ICL Vault
Status: RECRUITING
Conditions: Refractive Errors|Myopia|Myopic Astigmatism
Interventions: PROCEDURE: Refractive Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase 2 Dose-Ranging Study of SKY0402 for Prolonged Postoperative Analgesia in Subject Undergoing Hemorrhoidectomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: SKY0402|DRUG: Bupivacaine HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Fecal Microbiota Transplantation as add-on Therapy in Mild-to-moderate Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis Chronic Mild|Inflammatory Bowel Diseases
Interventions: DRUG: Mesalazine|BIOLOGICAL: Fecal transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Haplo-identical Viral-Specific T-cells for Treatment of Cytomegalovirus and Adenovirus Infections After Hematopoietic Cell Transplantation
Status: RECRUITING
Conditions: Cytomegalovirus|Adenovirus
Interventions: DRUG: VST infusion|DEVICE: CliniMACS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Assess the Safety and Pharmacokinetics of SRT2104 in Type 2 Diabetic Human Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: SRT2104|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Investigation to Evaluate the Healing of Tooth Extraction Sites Filled With BioRestore™
Status: COMPLETED
Conditions: Alveolar Bone Loss
Interventions: DEVICE: Alveolar Bone Defect Regeneration Following Tooth Extraction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase IIa Study of NT-KO-003 for Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: NT-KO-003
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of Virtual Reality and Vestibular Exercises on Balance Gait in Older Adults
Status: RECRUITING
Conditions: Old Age|Vestibular Disorder|Balance|Exercise
Interventions: OTHER: virtual reality training group|OTHER: vestibular exercise group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rosuvastatin in Visceral Adiposity
Status: COMPLETED
Conditions: Abdominal Obesity
Interventions: DRUG: Rosuvastatin|DRUG: Placebo for rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of AS-3201 in the Treatment of Diabetic Sensorimotor Polyneuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathy
Interventions: DRUG: ranirestat, (AS-3201)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety and Efficacy of a Single Treatment Cycle of EB-001 in Subjects With Glabellar Frown Lines
Status: COMPLETED
Conditions: Glabellar Frown Lines (GL)
Interventions: DRUG: EB-001 injection|DRUG: Placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Haploidentical and Umbilical Cord Blood Allogeneic Stem Cell Transplantation in Patients With Acute Leukemia
Status: UNKNOWN
Conditions: Acute Leukemia
Interventions: PROCEDURE: Combined haploidentical and umbilical cord blood allogeneic stem cell transplantation|PROCEDURE: haploidentical hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT