pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Combined Intracameral Lidocaine for Manual Small Incision Cataract Surgery Under Topical Anesthesia
Status: COMPLETED
Conditions: Cataract
Interventions: PROCEDURE: MSICS under topical anesthesia with intracameral lidocaine|PROCEDURE: MSICS under topical anesthesia with intracameral balanced salt solution.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Lasmiditan on Simulated Driving Performance - Healthy Participants
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Lasmiditan|DRUG: Alprazolam|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy, Transfer, and Neuro-functional Basis of a Memory Training Targeting Episodic Retrieval in Older Adults.
Status: COMPLETED
Conditions: Healthy
Interventions: BEHAVIORAL: Episodic Specificity Induction|BEHAVIORAL: Associative Memory
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Superficial Serratus Plane Block for Modified Radical Mastectomy and Axillary Lymph Node Disection
Status: COMPLETED
Conditions: Postoperative Analgesia|Pain, Postoperative|Opioid Consumption
Interventions: DRUG: Bupivacaine|DRUG: Saline|DEVICE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Soy Dietary Fiber in Adults With Diarrhea Predominant Irritable Bowel Syndrome
Status: UNKNOWN
Conditions: Diarrhea Predominant Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Soy Dietary Fiber|DIETARY_SUPPLEMENT: Rice powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Intranasal Insulin to Treat Tobacco Abstinence Syndrome
Status: COMPLETED
Conditions: Tobacco Abstinence Syndrome
Interventions: DRUG: Intranasal Insulin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)
Status: RECRUITING
Conditions: ER-Positive HER2-Negative Breast Cancer
Interventions: DRUG: AZD9833|DRUG: AZD9833 Placebo|DRUG: Anastrozole|DRUG: Anastrozole placebo|DRUG: Letrozole|DRUG: Letrozole placebo|DRUG: Palbociclib|DRUG: Abemaciclib|DRUG: Luteinizing hormone-releasing hormone (LHRH) agonist|DRUG: Ribociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ceralasertib Monotherapy and Ceralasertib Plus Durvalumab in Patients With Melanoma and Resistance to PD-(L)1 Inhibition
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: DRUG: Ceralasertib|BIOLOGICAL: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Intravenous Citrulline for the Prevention of Bronchopulmonary Dysplasia in Preterm Infants
Status: WITHDRAWN
Conditions: Bronchopulmonary Dysplasia
Interventions: DRUG: Intravenous L-Citrulline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Effects of Transcutaneous Vagal Nerve Stimulation on Postural Orthostatic Tachycardia Syndrome (POTS)
Status: UNKNOWN
Conditions: Orthostatic Intolerance|Postural Tachycardia Syndrome|Syncope, Postural|Physical Disability|Autonomic Dysfunction
Interventions: DEVICE: Transcutaneous vagal nerve stimulation (tVNS)|OTHER: Placebo|DEVICE: Home daily transcutaneous vagal nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Itraconazole and Rifampin on Pharmacokinetics (PK) of Vemurafenib at Steady State
Status: COMPLETED
Conditions: Metastatic Melanoma, BRAF V600 Mutation Positive
Interventions: DRUG: Itraconazole|DRUG: Rifampin|DRUG: Vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Looking to Improve Sleep and Reduce Sedentary Behaviour in Those Living With Type 2 Diabetes Mellitus
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2|Insomnia|Sedentary Behavior
Interventions: BEHAVIORAL: CBTi|OTHER: Control - usual care|BEHAVIORAL: Sedentary behaviour reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative and Pragmatic Study of Golimumab Intravenous (IV) (Simponi Aria) Versus Infliximab (Remicade) in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: BIOLOGICAL: Golimumab Intravenous (IV)|BIOLOGICAL: Infliximab|BIOLOGICAL: Biosimilar Infliximab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy Evaluation of Sequential Treatment With AG and Modified Folfirinox in Metastatic Pancreatic Adenocarcinoma
Status: RECRUITING
Conditions: Pancreatic Adenocarcinoma Metastatic|Chemotherapy Effect
Interventions: DRUG: Sequential Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of CHF 5993 pMDI With and Without Spacer in COPD Patients
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Beclometasone/formoterol/glycopyrrolate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NTX-301 Monotherapy in Advanced Solid Tumours and in Combination With Platinum-based Chemotherapy in Advanced Ovarian & Bladder Cancer and in Combination With Temozolomide in High-grade Glioma
Status: TERMINATED
Conditions: Advanced Solid Tumor|Platinum-Resistant Ovarian Cancer|Platinum-Resistant Urothelial Carcinoma|High-grade Glioma
Interventions: DRUG: NTX-301|DRUG: Platinum-based Chemotherapy|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Safety/Efficacy of Transdermal Testosterone in Female Patients With Symptomatic Heart Failure
Status: TERMINATED
Conditions: Heart Failure
Interventions: DRUG: placebo|DRUG: testosterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fasting BE Study of Metformin Hydrochloride ER Tablets 500 mg and Glucophage® XR Tablets 500 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Metformin Hydrochloride ER Tablets 500 mg|DRUG: Glucophage® XR Tablets 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Nordic Adjuvant IFN Melanoma Trial
Status: COMPLETED
Conditions: Melanoma|Adjuvant Therapy
Interventions: DRUG: Interferon-alpha2b - 1 year|DRUG: Interferon-alpha2b - 2 years
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of Efficacy and Safety of Secukinumab Versus Placebo, in Combination With Glucocorticoid Taper Regimen, in Patients With Polymyalgia Rheumatica (PMR)
Status: ACTIVE_NOT_RECRUITING
Conditions: Polymyalgia Rheumatica
Interventions: DRUG: Secukinumab 300 mg|DRUG: Secukinumab 150 mg|OTHER: Placebo to secukinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Simulation of Risk of Adverse Drug Events Associated With the Initiation of Drugs Repurposed for the Treatment of COVID-19 in Frail Elderly Adults With Polypharmacy
Status: COMPLETED
Conditions: COVID|Drug Effect|Drug Interaction|Adverse Drug Event
Interventions: OTHER: Simulation of Repurposed Drugs for COVID-19
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tislelizumab Combined With Chemotherapy (CAPOX) in the Perioperative Treatment of MSI-H/dMMR Stage II or III Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: MSI-H Colorectal Cancer|Tislelizumab|Oxaliplatin|Capecitabine
Interventions: DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Administration of Alpha Blockers for Prevention of Urinary Retention in Males Undergoing Inguinal Hernia Repair Under Spinal Anaesthesia.
Status: COMPLETED
Conditions: Inguinal Hernia|Urinary Retention
Interventions: DRUG: Tamsulosin|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Stem Cell Transplantation Compared to Rehabilitation Treatment of Patients With Cerebral Paralysis
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: rehabilitation|BIOLOGICAL: stem cell injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of HRS2300 or Combined With SHR-1316 or SHR-1701 or Trametinib or Almonertinib in Patients With Advanced Malignancies
Status: RECRUITING
Conditions: Advanced Malignancies
Interventions: DRUG: HRS2300|DRUG: HRS2300、 SHR-1316|DRUG: HRS2300、SHR-1701|DRUG: HRS2300、trametinib|DRUG: HRS2300、Almonertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glucose Variability in Subclinical Hypertrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus|Lipohypertrophy
Interventions: OTHER: Lipohypertrophy|OTHER: Normal Subcutaneous Tissue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: S0304 Induct Chemo Then Chemo-RT in Pts w/Locally Advanced Adenocarcinoma of the Rectum
Status: WITHDRAWN
Conditions: Colorectal Cancer
Interventions: DRUG: capecitabine|DRUG: fluorouracil|DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium|DRUG: oxaliplatin|RADIATION: radiation therapy|DRUG: Pyridoxine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methotrexate, Vincristine, Pegylated L-Asparaginase and Dexamethasone (MOAD) in Acute Lymphoblastic Leukemia (ALL) Salvage
Status: COMPLETED
Conditions: Leukemia, Lymphocytic, Acute
Interventions: DRUG: Methotrexate|DRUG: Vincristine|DRUG: PEG-l-asparaginase|DRUG: Dexamethasone|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Leflunomide to Treat Juvenile Idiopathic Arthritis
Status: UNKNOWN
Conditions: Juvenile Idiopathic Arthritis
Interventions: DRUG: Leflunomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neurobehavioral Plasticity to Regular Sugar-Sweetened Beverage Intake: An fMRI Experiment
Status: COMPLETED
Conditions: Obesity|Weight Gain
Interventions: DIETARY_SUPPLEMENT: Black Cherry and Orange Flavored Beverage with added sugar|DIETARY_SUPPLEMENT: Strawberry Kiwi &Lemonade Flavored Beverage with added sugar|DIETARY_SUPPLEMENT: Black Cherry and Orange Flavored Beverage no added sugar|DIETARY_SUPPLEMENT: Strawberry Kiwi & Lemonade Flavored Beverage no added sugar|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Diabetes Control and Effect on Transmission and Development of Tuberculosis
Status: WITHDRAWN
Conditions: Latent Tuberculosis|Diabetes Mellitus
Interventions: DRUG: Isoniazid 300Mg Tab|DRUG: Isoniazid 300 MG|DRUG: Isoniazid 300 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Lubiprostone in Patients With Multiple Sclerosis Associated Constipation
Status: COMPLETED
Conditions: Multiple Sclerosis|Constipation
Interventions: DRUG: Lubiprostone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metastasis-directed Therapy in Castration-refractory Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Castration-resistant Prostate Cancer
Interventions: OTHER: Radiotherapy (SBRT) and/or surgery (metastasectomy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Penpulimab-based Combination Neoadjuvant/Adjuvant Therapy for Patients With Resectable Locally Advanced Non-small Cell Lung Cancer: a Phase II Clinical Study (ALTER-L043)
Status: NOT_YET_RECRUITING
Conditions: Resectable Locally Advanced Non-small Cell Lung Cancer
Interventions: DRUG: Penpulimab+Cisplatin/Carboplatin+Pemetrexed/Paclitaxel/Gemcitabine/Docetaxel|DRUG: Penpulimab+Anlotinib+Cisplatin/Carboplatin+Pemetrexed/Paclitaxel/Gemcitabine/Docetaxel|DRUG: Penpulimab+Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Interferon Beta-1a (Avonex®) in Ulcerative Colitis
Status: COMPLETED
Conditions: Active Ulcerative Colitis
Interventions: DRUG: BG9418 (Interferon beta-1a)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Laparoendoscopic Rendez Vous Versus Standard Two Stage Approach for the Management of Cholelithiasis/Choledocholithiasis
Status: UNKNOWN
Conditions: Choledocholithiasis|Cholelithiasis
Interventions: PROCEDURE: Laparoendoscopic Rendez vous|PROCEDURE: preoperative ERCP and CBD clearance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-initiated Episodic Treatment of Recurrent Genital Herpes in Black Patients
Status: COMPLETED
Conditions: Genital Herpes
Interventions: DRUG: Famciclovir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CAMP Air: Efficacy and Cost-effectiveness in Urban Adolescents
Status: ENROLLING_BY_INVITATION
Conditions: Asthma
Interventions: BEHAVIORAL: Controlling Asthma Program for Adolescents (CAMP Air)|BEHAVIORAL: Attention Control Asthma Education Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Osteopathic Technique on Autonomic Nervous System Activity
Status: RECRUITING
Conditions: Healthy|Dysautonomia
Interventions: PROCEDURE: CV4 + RR|PROCEDURE: CV4|DEVICE: sham ultrasound transducer|DEVICE: Ultrasound Transducer Sham Procedure|DEVICE: EEG/HRV/RSA (Electroencephalography, Heart Rate Variability, Respiratory Sinus Arrhythmia) Monitoring using Infiniti System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combine GELOX With Concurrent Radiation Therapy for Patients With Stage IE/IIE ENKTL
Status: UNKNOWN
Conditions: Lymphoma, Extranodal NK-T-Cell
Interventions: DRUG: GELOX|RADIATION: IFRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breast Ultrasound Image Reviewed With Assistance of Deep Learning Algorithms
Status: UNKNOWN
Conditions: Breast Cancer|Breast Lesions|Breast Mass
Interventions: DEVICE: Ultrasound Image review with CADe|DEVICE: Ultrasound Image review with CADx|DEVICE: Ultrasound Image manual review|PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Study of the Diagnostic Value of Hybrid PET/MR and PET/CT in Neuroendocrine Diseases and Tumor Induced Osteomalacia
Status: RECRUITING
Conditions: PET / CT|PET / MR|Neuroendocrine Tumors|Osteomalacia
Interventions: DEVICE: 68Ga-DOTA-TATE PET/MR and PET/CT imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Peritoneal Microdialysis in Patients Undergoing Low Anterior Resection for Rectum Cancer
Status: UNKNOWN
Conditions: Cancer
Interventions: PROCEDURE: Peritoneal Microdialysis, CT-scan, leakage scoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vaccine Therapy in Reducing the Frequency of Cytomegalovirus Events in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant
Status: ACTIVE_NOT_RECRUITING
Conditions: Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Myeloid Leukemia in Remission|Adult Hodgkin Lymphoma|Adult Non-Hodgkin Lymphoma|Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Cytomegaloviral Infection|Hematopoietic and Lymphoid Cell Neoplasm|HLA-A*0201 Positive Cells Present|Myelodysplastic Syndrome|Adult Lymphoblastic Lymphoma|Chronic Lymphocytic Leukemia|Myelofibrosis|Myeloproliferative Neoplasm
Interventions: BIOLOGICAL: CMVpp65-A*0201 peptide vaccine|OTHER: Placebo|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Radiation Therapy and Capecitabine With or Without Curcumin Before Surgery in Treating Patients With Rectal Cancer
Status: TERMINATED
Conditions: Rectal Mucinous Adenocarcinoma|Rectal Signet Ring Cell Adenocarcinoma|Recurrent Rectal Carcinoma|Stage IIA Rectal Cancer AJCC v7|Stage IIB Rectal Cancer AJCC v7|Stage IIC Rectal Cancer AJCC v7|Stage IIIA Rectal Cancer AJCC v7|Stage IIIB Rectal Cancer AJCC v7|Stage IIIC Rectal Cancer AJCC v7
Interventions: DRUG: Capecitabine|DIETARY_SUPPLEMENT: Curcumin|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|OTHER: Placebo|OTHER: Quality-of-Life Assessment|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Double-Blind, Multicenter, Sham Surgery Controlled Study of CERE-120 in Subjects With Idiopathic Parkinson's Disease
Status: COMPLETED
Conditions: Idiopathic Parkinson's Disease
Interventions: DRUG: CERE-120 (Adeno-Associated Virus Serotype 2 [AAV2]-Neurturin [NTN])|PROCEDURE: Sham Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repurposing Lithium for Parkinson's Disease: a RCT
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: DIETARY_SUPPLEMENT: Lithium|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Immunoglobulin and Prednisolone for RPL After ART.
Status: UNKNOWN
Conditions: Habitual Abortion|Recurrent Pregnancy Loss|Fertility Disorders|Miscarriage
Interventions: DRUG: Human Intravenous Immunoglobulins, (Privigen (R), CLS Behring)|DRUG: Prednisolone Tablets|DRUG: Human Albumin Solution|DRUG: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IV or IV/PO Omadacycline vs. IV/PO Levofloxacin for the Treatment of Acute Pyelonephritis
Status: COMPLETED
Conditions: Acute Pyelonephritis
Interventions: DRUG: Omadacycline|DRUG: Levofloxacin|DRUG: Omadacycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy With or Without Cyclophosphamide and Doxorubicin in Women With Stage IV Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: allogeneic GM-CSF-secreting breast cancer vaccine|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes
Status: RECRUITING
Conditions: PSP|CBD|Progressive Supranuclear Palsy|FTD|Corticobasal Degeneration|Frontotemporal Dementia|Frontotemporal Lobar Degeneration
Interventions: DEVICE: PAMSys|DEVICE: LEGSys
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Skills Based Counseling for Adherence and Depression in HIV+ Methadone Patients - 1
Status: COMPLETED
Conditions: Adherence|Depression|Heroin Dependence|Methadone|Motivational Interviewing|Substance-Related Disorders
Interventions: BEHAVIORAL: CBT-AD|BEHAVIORAL: ETAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of 68Ga-PSMA-11 PET (Prostate Specific Membrane Antigen) in Surgery Guidance in Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: 68Ga-PSMA-11 PET Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Correlation Between Cytokines and Hepatic Histology in Patients Infected by HIV-1 and the Hepatitis-C Virus
Status: UNKNOWN
Conditions: Acquired Immune Deficiency Syndrome|Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted|HIV Infections
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mild Therapeutic Hypothermia for Patients With Acute Coronary Syndrome and Cardiac Arrest Treated With PCI
Status: TERMINATED
Conditions: Cardiac Arrest|Acute Coronary Syndrome
Interventions: PROCEDURE: Mild Therapeutic Hypothermia (MHT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Possible Antifibrotic Effect of Zinc Sulphate in Chronic HCV Patient Receiving Direct Acting Anti-viral Therapy.
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Zinc Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Zoledronic Acid, Pravastatin, and Lonafarnib for Patients With Progeria
Status: COMPLETED
Conditions: Progeria|Hutchinson-Gilford Syndrome
Interventions: DRUG: Lonafarnib|DRUG: Zoledronic Acid|DRUG: Pravastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ticagrelor Versus Clopidogrel in Left Ventricular Remodeling After ST-segment Elevation Myocardial Infarction
Status: UNKNOWN
Conditions: ST Elevation Myocardial Infarction
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Garcinia in Combination With Chromium on the Clinical Outcomes of Patients With LUTS/BPH
Status: RECRUITING
Conditions: Prostatic Hyperplasia
Interventions: DRUG: Chromax|DRUG: Sildosin Group|OTHER: Placebo Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Domperidone in Treating Patients With Gastrointestinal Disorders
Status: RECRUITING
Conditions: Digestive System Disorder|Dyspepsia|Esophagitis|Gastroesophageal Reflux Disease|Gastroparesis|Heartburn|Nausea and Vomiting
Interventions: DRUG: Domperidone|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplemental Parenteral Nutrition in Critically Ill Adults: A Pilot Randomised Controlled Trial
Status: COMPLETED
Conditions: Multiple Organ Failure|Critical Illness
Interventions: OTHER: Supplemental PN|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hematopoietic Stem Cell Support Versus Insulin in T1D
Status: WITHDRAWN
Conditions: Diabetes Mellitus, Type 1
Interventions: BIOLOGICAL: Autologous Hematopoietic Stem Cell Transplantation|DRUG: intensive insulin therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of AVE1625 as a Co-treatment With Antipsychotic Therapy in Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: AVE1625|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Esomeprazole/Vonoprazan Combined With High-dose Amoxicillin Dual Therapy for Primary Eradication of Helicobacter Pylori Infection
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: esomeprazole + amoxicillin|DRUG: esomeprazole + amoxicillin + clarithromycin + colloidal bismuth tartrate agent|DRUG: Vonoprazan + amoxicillin|DRUG: Vonoprazan + amoxicillin + clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Haemodynamic Effects of Peritoneal Dialysis as Evaluated by Sphygmocor Technology
Status: COMPLETED
Conditions: Peritoneal Dialysis
Interventions: PROCEDURE: Different abdominal volumes and different glucose-concentrations during peritoneal dialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Changes to Skin Microbiome With Tape-Stripped Wounds
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DEVICE: ADHESIVE BANDAGE #1|DEVICE: ADHESIVE BANDAGE #2|DEVICE: ADHESIVE BANDAGE #3|DEVICE: Antibacterial Bandage with 0.8% BZK|OTHER: Intact and No Bandage|OTHER: Wounded and No Bandage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Small Protein and Lipid Preload on Glucose Tolerance in Subjects With Impaired Glucose Homeostasis
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DIETARY_SUPPLEMENT: Small mixed protein and lipid meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Curcumin for Treatment of Cancer Anorexia-Cachexia Syndrome in Patients With Stage III-IV of Head and Neck Cancer
Status: COMPLETED
Conditions: Cancer Cachexia|Head and Neck Cancer|Head and Neck Neoplasms
Interventions: DIETARY_SUPPLEMENT: Curcumin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: University Of Pennsylvania Weight Loss Study
Status: COMPLETED
Conditions: Weight Loss
Interventions: BEHAVIORAL: Deposit contract with a 1:1 match|BEHAVIORAL: Deposit contract with a 2:1 match|BEHAVIORAL: Deposit Contract with no match
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III
Status: COMPLETED
Conditions: Intraventricular Hemorrhage
Interventions: DRUG: Alteplase|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RC48-ADC in Subjects With Advanced Breast Cancer
Status: COMPLETED
Conditions: Advanced Breast Cancer
Interventions: DRUG: RC48-ADC 1.5 mg/kg (HER2 Positive)|DRUG: RC48-ADC 2.0 mg/kg (HER2 Positive)|DRUG: RC48-ADC 2.5 mg/kg (HER2 Positive)|DRUG: RC48-ADC 2.0 mg/kg (HER2 Low Expression)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: End Tidal Control of Sevoflurane
Status: COMPLETED
Conditions: Anesthesia of Living Donor Hepatectomy
Interventions: DEVICE: End tidal control module in Aisys anesthesia workstation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Evaluate the Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of Erythropoietin
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: GC1113|DRUG: Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Brain Stimulation to Evaluate Neural Plasticity After Stroke
Status: TERMINATED
Conditions: Cerebrovascular Stroke
Interventions: DEVICE: Transcranial Magnetic Stimulation|DEVICE: Traditional Paired Associative Stimulation|DEVICE: Median Nerve Stimulation|DEVICE: Corticocortical Paired Associative Stimulation|DEVICE: Sham Paired Associative Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Early Coordinated Multidisciplinary Intervention to Prevent Sickness Absence and Labor Market Exclusion in Patients With Low Back Pain.
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: PROCEDURE: Multidisciplinary intervention|PROCEDURE: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Clinical Trial of Pazopanib in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) or at Initial Diagnosis When no Intensive Treatment is Possible
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Group Drumming for Improving the Health of Community-Dwelling Elderly
Status: NOT_YET_RECRUITING
Conditions: Quality of Life|Depression|Sleep|Blood Pressure|Grip
Interventions: OTHER: Group Drumming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of Metacognitive Training for Depression (D-MCT) in Outpatient Care
Status: COMPLETED
Conditions: Unipolar Depression
Interventions: BEHAVIORAL: D-MCT|BEHAVIORAL: Cognitive remediation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dysphagia Following Anterior Cervical Spine Surgery; Steroid vs Saline
Status: COMPLETED
Conditions: Dysphagia
Interventions: DRUG: Treatment 1; Dexamethasone|DRUG: Treatment 0; Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Allo Non-Myeloablative SCT Utilizing Mis-Matched Family Member Stem Cells Purged Using Campath
Status: COMPLETED
Conditions: Lymphoma|Myeloma|Leukemia|Myelodysplasia|Solid Tumors
Interventions: DRUG: Campath Purged Non-myeloablative ASCT|PROCEDURE: Donor Apheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Feasibility Study Comparing Smartphone Home-based Rehabilitation Program Against the Usual Hospital and Outpatient Physiotherapy Care on Clinical and Cost Effectiveness for Total Knee Replacement Patients
Status: NOT_YET_RECRUITING
Conditions: Knee Arthropathy
Interventions: DEVICE: Smartphone application with tele-monitoring rehabilitation|PROCEDURE: Hospital-based rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hemicraniectomy for Malignant Middle Cerebral Artery Infarction (HeMMI)
Status: TERMINATED
Conditions: Infarction
Interventions: PROCEDURE: Hemicraniotomy|PROCEDURE: Standard medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Statin Drugs to Prevent Complications During Surgery
Status: COMPLETED
Conditions: Inflammation|Myocardial Infarction|Myocardial Ischemia
Interventions: DRUG: Atorvastatin|DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Arestin - Use in Subjects With Peri-Implantitis (With Subgingival Microbiological Evaluation)
Status: COMPLETED
Conditions: Peri-Implantitis
Interventions: DRUG: Minocycline HCl Microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Interactive Nursing Education Program Through Health Belief Model Based and Informative Technology-assisted on Atrial Fibrillation Patients Receiving Oral Anticoagulant
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: OTHER: Patient education related oral anticoagulants (OACs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Add-on Intravenous Immunoglobulins in Early Myositis
Status: RECRUITING
Conditions: Inflammatory Myopathy, Idiopathic|Dermatomyositis|Antisynthetase Syndrome|Immune-Mediated Necrotizing Myopathy|Polymyositis|Myositis
Interventions: DRUG: Immune Globulin Intravenous (Human)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RGT001-075 in Adult Patients With Obesity
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: DRUG: RGT001-075|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate Efficacy and Safety of SMUP-IA-01 in Patients With Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: SMUP-IA-01(low dose)|BIOLOGICAL: SMUP-IA-01(mid dose)|DRUG: Active Control Group Sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mononucleotide Autologous Stem Cells and Demineralized Bone Matrix in the Treatment of Non Union/Delayed Fractures
Status: UNKNOWN
Conditions: Non Union/Delayed Fractures
Interventions: DEVICE: the Sepax is a tool to standardize adult stem cell. Ignite ®ICS injectable scaffold manufactured by Wright Medical Technology.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Experience With Topical Acne Treatment
Status: NOT_YET_RECRUITING
Conditions: Acne
Interventions: DRUG: Adapalene Gel|DRUG: Adapalene Gel and the clindamycin phosphate/benzoyl peroxide gel|DRUG: adapalene, benzoyl peroxide gel, and clindamycin phosphate gel every day.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ostene in Thoracolumbar Decompression and Fusion Evaluated With VIBE
Status: NOT_YET_RECRUITING
Conditions: Intraoperative Complications|Intraoperative Bleeding|Intraoperative Blood Loss|Hemostasis|Blood Transfusion|Postoperative Hemorrhage|Postoperative Complications|Spine Fusion|Thoracolumbar Spine
Interventions: DEVICE: Ostene
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TCRx_T Cells for Advanced or Recurrent Gastric/Gastroesophageal Junction Cancer After Failure of First Chemotherapy
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer|Gastroesophageal-junction Cancer
Interventions: BIOLOGICAL: Tcrx T cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Platelet Rich Plasma (PRP) on Mouth Opening and Pain After Surgical Extraction of Mandibular Third Molars.
Status: COMPLETED
Conditions: Tooth Extraction
Interventions: PROCEDURE: Platelet Rich Plasma (PRP)|PROCEDURE: Surgical Extraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Balloon-Stent Kissing Technique Versus Jailed Wire Technique for the Coronary Bifurcation Lesions
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Balloon-Stent Kissing technique|PROCEDURE: Jailed Wire technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hybrid Closed Loop Therapy and Verapamil for Beta Cell Preservation in New Onset Type 1 Diabetes
Status: COMPLETED
Conditions: Type1 Diabetes
Interventions: DEVICE: HCL|DRUG: verapamil 120mg tablet|DEVICE: non-HCL|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing 14 F Pigtail Catheter to Traditional 28-32F Chest Tube in the Management of Traumatic Hemothorax and Hemopneumothorax
Status: UNKNOWN
Conditions: Traumatic Hemothorax
Interventions: DEVICE: Pigtail catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of NN1250 With Insulin Glargine in Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin degludec|DRUG: insulin glargine|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Intensity Haploidentical BMT for High Risk Solid Tumors
Status: RECRUITING
Conditions: Refractory and/or Relapsed Metastatic Solid Tumors
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|RADIATION: low dose total body irradiation|DRUG: Melphalan|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of 90Y-hLL2 to Treat Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Non-Hodgkins Lymphoma
Interventions: DRUG: hLL2 (epratuzumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bacteriophage Therapy in Patients With Prosthetic Joint Infections (PJI)
Status: WITHDRAWN
Conditions: Prosthetic Joint Infection
Interventions: DRUG: Bacteriophage|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of muLtimodal and Non-invasive SPINa Bifida Neurovessels During Prospective Follow-up
Status: RECRUITING
Conditions: Spina Bifida
Interventions: BIOLOGICAL: Collection of a urine sample|DIAGNOSTIC_TEST: Magnetic Resonance Imaging of the bladder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: First In Human (FIH) Study of REGN5459 in Adult Patients With Relapsed or Refractory Multiple Myeloma (MM)
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed Multiple Myeloma|Refractory Multiple Myeloma
Interventions: DRUG: REGN5459
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxcarbazepine as an Adjunct of Antipsychotic Therapy in Acute Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Oxcarbazepine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SONOlysis in Prevention of Brain InfaRctions During Internal Carotid Endarterectomy
Status: COMPLETED
Conditions: Internal Carotid Artery Stenosis
Interventions: DEVICE: sonolysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ruxolitinib in Treating Patients With Hypereosinophilic Syndrome or Primary Eosinophilic Disorders
Status: RECRUITING
Conditions: BCR-JAK2 Fusion Protein Expression|Blasts 20 Percent or Less of Peripheral Blood White Cells|Blasts More Than 5 Percent of Bone Marrow Nucleated Cells|Blasts More Than 5 Percent of Peripheral Blood White Cells|Blasts Under 20 Percent of Bone Marrow Nucleated Cells|Chronic Eosinophilic Leukemia, Not Otherwise Specified|Eosinophilia|Hepatomegaly|Hypereosinophilic Syndrome|JAK2 Gene Mutation|Splenomegaly|TEL-JAK2 Fusion Protein Expression
Interventions: DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Health-status of Patients With Chronic Obstructive Pulmonary Disease (COPD) on Maintenance Therapy With Spiriva HH Measured by COPD Assessment Test (CAT) Test
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Spiriva HandiHaler
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose:
Clinical trial: A Cross Sectional Evaluation of the Development in Children Age 4 to 7 Infected or Exposed to HIV From the ANRS 12140 Cohort (Pediacam)
Status: UNKNOWN
Conditions: HIV|HIV-uninfected Children|Children Exposed to HIV
Interventions: OTHER: HIV-infected children initiated antiretroviral treatment within the first 7 months of life
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effects of Adjunct Photodynamic Therapy in the Treatment of Type 2 Diabetic Patients With Chronic Periodontitis
Status: COMPLETED
Conditions: Chronic Periodontitis|Diabetes Mellitus
Interventions: PROCEDURE: Ultrasonic debridement|PROCEDURE: Antimicrobial photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety to Tenofovir Disoproxil in Chronic Hepatitis B Patients
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Tenofovir Disoproxil Fumarate|DRUG: Tenofovir Disoproxil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Atypical Antipsychotic Medication for Outpatients With Anorexia Nervosa
Status: COMPLETED
Conditions: Eating Disorders
Interventions: DRUG: Olanzapine|DRUG: Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Methylphenidate HCl Extended-Release Capsules in Children 4 to Under 6 Years of Age With ADHD
Status: COMPLETED
Conditions: Attention-Deficit/Hyperactivity Disorder
Interventions: DRUG: Methylphenidate HCl ER Capsules, 10 mg|DRUG: Methylphenidate HCl ER Capsules, 15 mg|DRUG: Methylphenidate HCl ER Capsules, 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Minocycline Study in Non Small Cell Lung Cancer (NSCLC) Patients for Chemoradiation Therapy
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Minocycline|OTHER: Placebo|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT