pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety of Calcifediol vs Placebo in Subjects With Vitamin D Deficiency
Status: COMPLETED
Conditions: Vitamin D Deficiency|Vitamin D Insufficiency
Interventions: DRUG: Calcifediol 75mcg|DRUG: Calcifediol 100mcg|DRUG: Calcifediol 125mcg|OTHER: Placebo|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Gefapixant (MK-7264) in Women With Endometriosis-Related Pain (MK-7264-034)
Status: COMPLETED
Conditions: Endometriosis-related Pain
Interventions: DRUG: Gefapixant|DRUG: Placebo|DRUG: Naproxen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Immediate Effects of Applying Dynamic Tape, Kinesio Tape and Sport Tape With Chronic Ankle Instability
Status: UNKNOWN
Conditions: Taping|Ankle Sprains
Interventions: OTHER: Dynamic tape|OTHER: Kinesio tape|OTHER: Sport tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Aerobic and Strength Exercice on Nociplastic Pain in Temporomandibular Disorders
Status: NOT_YET_RECRUITING
Conditions: Temporomandibular Disorders (TMD)|Nociplastic Pain|Aerobic Exercise|Strengthening Exercises|Myofascial Pain Dysfunction Syndrome, Temporomandibular Joint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Study to Investigate the Safety and Efficacy of Fermagate and Lanthanum Carbonate
Status: TERMINATED
Conditions: Chronic Kidney Failure
Interventions: DRUG: Magnesium iron hydroxycarbonate|DRUG: Lanthanum carbonate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Effectiveness of OLMETEC® and OLMETEC PLUS® for Treatment of Hypertension in Stage I and II Patients (Study P05254)(COMPLETED)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: olmesartan medoxomile alone or combined with hydrochlorothiazide,
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intubation With Storz Videolaryngoscope® Versus Airtraq® - in an Infant Population
Status: COMPLETED
Conditions: Intubation|Videolaryngoscopy|Infant
Interventions: DEVICE: Storz videolaryngoscope|DEVICE: Airtraq
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prediction of pCR by Preoperative Biopsy in Breast Cancer With cCR After Neoadjuvant Chemotherapy.
Status: COMPLETED
Conditions: Breast Neoplasm
Interventions: PROCEDURE: Minimally-invasive biopsy|PROCEDURE: wide excision
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pilot Clinical Trial With Tocotrienol on Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DIETARY_SUPPLEMENT: Tocotrienol Rich Fraction (TRF)|OTHER: placebo plus tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cranberry and Quillaja on Symptoms of Uncomplicated UTI
Status: TERMINATED
Conditions: Urinary Tract Infections|UTI|UTI - Lower Urinary Tract Infection
Interventions: OTHER: Pacran and Sapnov P quillaja
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The AMPLATZER™ Post-infarct Muscular VSD Occluder Humanitarian Device Exemption (H070005) Post Approval Study
Status: COMPLETED
Conditions: Post-Infarction Ventricular Septal Defect
Interventions: DEVICE: AMPLATZER™ Post-infarct Muscular VSD Occluder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Explore Pamiparib Treatment in Epithelial Ovarian Cancer After Prior PARP Inhibitor Exposure
Status: ACTIVE_NOT_RECRUITING
Conditions: Epithelial Ovarian Cancer
Interventions: DRUG: Pamiparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outpatient PDD Guided Laser Mediated Destruction of Bladder Tumors
Status: UNKNOWN
Conditions: Bladder Cancer
Interventions: DEVICE: Bladder tumor resection using diathermia|DEVICE: Diode laser (980 nm) tumor destruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficiency of Bipolar Energy Versus Monopolar Energy in Endometrial Ablation in Women Having Menorrhagia
Status: COMPLETED
Conditions: Menorrhagia
Interventions: PROCEDURE: Monopolar current|PROCEDURE: Bipolar current
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: ILM Peeling Versus Inverted Flap Technique for Treatment of Macular Hole: Near Visual Acuity Outcomes
Status: UNKNOWN
Conditions: Macular Holes
Interventions: PROCEDURE: 25-gauge pars plana vitrectomy with complete internal limiting membrane peeling and SF6 tamponade|PROCEDURE: 25-gauge pars plana vitrectomy with inverted flap technique and SF6 tamponade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Multisensory Stimulation Exercises And Task Oriented Exercises On Upper Limb Function In Post Stroke Patients.
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Multi Sensory stimulation exercises|OTHER: Task Oriented Exercises|OTHER: Task-oriented exercises and Multisensory stimulation Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3202626 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3202626 (R-Fasting)|DRUG: LY3202626 (T1-Fasting)|DRUG: LY3202626 (T1-Fed)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Theory-based Text Messaging to Reduce Methamphetamine Use and HIV Risks Among MSM
Status: COMPLETED
Conditions: Methamphetamine Abuse|HIV
Interventions: BEHAVIORAL: Text Messages Transmitted by Peer Health Educators (TXT-PHE)|BEHAVIORAL: Text Messages Transmitted by Automation (TXT-Auto)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: To Evaluate the Safety, Tolerability, Efficacy and Immunogenicity of BNT162b2 Boosting Strategies Against COVID-19 in Participants ≥12 Years of Age.
Status: COMPLETED
Conditions: SARS-CoV-2 Infection|COVID-19
Interventions: BIOLOGICAL: BNT162b2|OTHER: Placebo|BIOLOGICAL: BNT162b2 OMI|BIOLOGICAL: Combination BNT162b2 and BNT162b2 OMI|BIOLOGICAL: Combination (Bivalent) BNT162b2 and BNT162b2 OMI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Physiological Effects of HFNC During Exercise in Patients With Fibrosing Interstitial Lung Diseases
Status: RECRUITING
Conditions: Interstitial Lung Disease|Pulmonary Rehabilitation
Interventions: DEVICE: high flow nasal canulae|DEVICE: Ventury mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: THC + CBD and Memory Study
Status: UNKNOWN
Conditions: Marijuana Use|Cannabis Use|Cannabis Intoxication
Interventions: DRUG: High THC/No CBD Marihuana|DRUG: High THC/High CBD Marihuana|DRUG: No THC/No CBD Marihuana
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of COVIDEX™ Therapy in Management of Adult COVID-19 Patients in Uganda.
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: COVIDEX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical, Anti-Inflammatory And Anti-Infective Properties Of Amniotic Membranes Used For Guided Tissue Regeneration
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: DEVICE: Amniotic Membrane|DEVICE: Control group (Hydroxyapatite only)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: TEsting for Arterial Disease in Diabetes (TrEAD) Study
Status: COMPLETED
Conditions: Diabetic Foot|Peripheral Arterial Disease|Diabetic Foot Ulcer|Peripheral Vascular Diseases|Peripheral Artery Disease|Critical Limb Ischemia|Critical Lower Limb Ischemia
Interventions: DIAGNOSTIC_TEST: Transcutaneous pressure of oxygen (TcPO2)|DIAGNOSTIC_TEST: Toe Brachial Pressure Index (TBPI)|DIAGNOSTIC_TEST: Podiatry Ankle Duplex scan (PAD-scan)|DIAGNOSTIC_TEST: Duplex Assist|DIAGNOSTIC_TEST: Ankle Brachial Pressure Index (ABPI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SELESTIAL: Trial of Insulin to Control Blood Sugar After Acute Stroke Using Magnetic Resonance Imaging (MRI) End-Points
Status: COMPLETED
Conditions: Acute Stroke|Hyperglycemia
Interventions: DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Silodosin in the Treatment of Premature Ejaculation
Status: UNKNOWN
Conditions: Premature Ejaculation
Interventions: DRUG: Silodosin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Efficacy and Safety of EFLA400 Korea Red Ginseng Extract on Sexual Function in Men With Erectile Dysfunction
Status: COMPLETED
Conditions: Healthy Subjects(Only Men)
Interventions: DIETARY_SUPPLEMENT: EFLA400|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Dovitinib for Patients With Tumor Pathway Activations Inhibited by Dovitinib
Status: COMPLETED
Conditions: Tumor Pathway Activations Inhibited by Dovitinib
Interventions: DRUG: Dovitinib (TKI258)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Happy Teeth for Hopi Tots: Cultural Adaptation of an Oral Health Entertainment-Education Intervention
Status: WITHDRAWN
Conditions: Early Childhood Caries
Interventions: BEHAVIORAL: Culturally adapted children's book|BEHAVIORAL: Standard informational brochure on children's oral health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparative Study of Duration of Respiratory Weaning Between Adaptive Support Ventilation and Succession of Controlled Ventilation Then Spontaneous Ventilation for Patients After Surgery
Status: TERMINATED
Conditions: Ventilator Weaning
Interventions: PROCEDURE: Adaptative Support Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Dose Study of GRN163L Administered to Treat Patients With Refractory or Relapsed Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Imetelstat Sodium (GRN163L)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-ranging Trial of OPC-249 Powder Inhalation in Patients With Pain Due to Osteoporosis
Status: COMPLETED
Conditions: Pain Due to Osteoporosis
Interventions: DRUG: OPC-249
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Clinical Trial of a GamLPV, a Live Intranasal Bordetella Pertussis Vaccine
Status: UNKNOWN
Conditions: Whooping Cough
Interventions: BIOLOGICAL: Vaccine GamLPV|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Mucosal IgE to Improve Diagnosis of Food Allergy and Food Hypersensitivity
Status: RECRUITING
Conditions: Food Allergy|Food Hypersensitivity
Interventions: OTHER: biopsy sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Flexible-dose Brexpiprazole as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder, the Delphinus Trial
Status: COMPLETED
Conditions: Depressive Disorder|Depression|Depressive Disorder, Major|Mood Disorders|Mental Disorders
Interventions: DRUG: Brexpiprazole|DRUG: Seroquel XR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaginal Estrogen on Postpartum Atrophy, Perineal Pain, and Sexual Function
Status: COMPLETED
Conditions: Vaginal Atrophy
Interventions: DRUG: Estradiol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preperitoneal Analgesia Versus Epidural Analgesia After Open Pancreaticoduodenectomy
Status: RECRUITING
Conditions: Pain Management|Pain, Postoperative
Interventions: DEVICE: Epidural patient controlled analgesia|DEVICE: Preperitoneal analgesia and IV-PCA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Prospective Study Comparing the Accuracy of Olympus Lucera Spectrum Technology vs Olympus Lucera Elite Technology in the in Vivo Diagnosis of Barrett's Oesophagus and Colorectal Polyps: The ELITE Study
Status: COMPLETED
Conditions: Barrett Esophagus|Polyps
Interventions: DEVICE: Olympus Elite|DEVICE: Olympus Spectrum
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessing Bioavailability of CoQ10 Supplementation in Burn Patients
Status: UNKNOWN
Conditions: Burn Injury
Interventions: DIETARY_SUPPLEMENT: coenzyme Q10|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Simvastatin Treatment of Patients With Acute Optic Neuritis
Status: UNKNOWN
Conditions: Optic Neuritis|Multiple Sclerosis
Interventions: DRUG: simvastatin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Investigational Immuno-therapy Trial of Nivolumab, or Nivolumab Plus Ipilimumab, or Nivolumab Plus Platinum-doublet Chemotherapy, Compared to Platinum Doublet Chemotherapy in Patients With Stage IV Non-Small Cell Lung Cancer (NSCLC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Gemcitabine|DRUG: Pemetrexed|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endometrial Thickness and Subendometrial Vascularity in Anovulatory Polycystic Ovarian Syndrome Patients Treated by Metformin
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome|Anovulatory
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification by Cytometry by Mass of Predictive Immunological Profiles of Answer to Treatmentby Biotherapics for Patients With Crohn's Disease
Status: WITHDRAWN
Conditions: Crohn Disease
Interventions: DRUG: Anti-TNF Drug|DRUG: Ustekinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Utility of Samples in Bacteriological Prospective Series of Ulcers Leg Infected Clinically
Status: ACTIVE_NOT_RECRUITING
Conditions: Leg Ulcer
Interventions: BIOLOGICAL: a swab according to the method of Levine|BIOLOGICAL: Bacteriological referred to biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Lovastatin Gel in the Treatment of Chronic Periodontitis
Status: COMPLETED
Conditions: Alveolar Bone Loss, Chronic Periodontitis, Lovestatin Gel, Regeneration
Interventions: DRUG: Lovastatin gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and PK of a Single Intravenous Dose of ETI-204 in Adult Volunteers
Status: COMPLETED
Conditions: Inhalational Anthrax
Interventions: BIOLOGICAL: ETI-204|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD
Status: RECRUITING
Conditions: Chronic Kidney Diseases|Metabolic Acidosis|Fatigue|Physical Endurance|Insulin Resistance|Mitochondrial Energetics|Diabetes
Interventions: DRUG: Sodium bicarbonate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Atorvastatin Therapy to Improve Endothelial Function in Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: Oxypurinol|DRUG: L-NMMA|DRUG: Acetylcholine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Peer Navigation to Link Released HIV+ Jail Inmates to HIV Care
Status: COMPLETED
Conditions: HIV-infection/Aids
Interventions: BEHAVIORAL: Peer Navigator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Supervised Physical Therapy With Early Activation of the Rotator Cuff Versus Home Exercises in Patients After Arthroscopic Subacromial Decompression
Status: COMPLETED
Conditions: Subacromial Decompression
Interventions: OTHER: Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Real-World Evidence Study Evaluating Oral Health Related Quality Of Life With Use Of A Stannous Fluoride Anti-Sensitivity Toothpaste For Dentin Hypersensitivity Management
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: OTHER: Stannous fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Safety and Efficacy With SAR445514 in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) and Relapsed/Refractory Light-chain Amyloidosis (RRLCA)
Status: RECRUITING
Conditions: Relapsed/Refractory Multiple Myeloma|Amyloid Light-chain Amyloidosis
Interventions: DRUG: SAR445514
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adaptive Interventions for Optimizing Malaria Control: A Cluster-Randomized SMART Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: LLIN, PBO LLIN, IRS, Larviciding
Interventions: OTHER: Regular long-lasting insecticidal nets|OTHER: LLIN plus Piperonyl butoxide-treated LLIN|OTHER: Long-lasting microbial larvicide|OTHER: Indoor residual spraying with micro-encapsulated pirimiphos-methyl or other insecticides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Standard Chemotherapy vs Immunotherapie in 2nd Line Treatment of MSI Colorectal Mestastatic Cancer
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer|MSI
Interventions: DRUG: FOLFOX regimen|DRUG: FOLFIRI Protocol|DRUG: Avelumab|DRUG: Panitumumab|DRUG: Cetuximab|DRUG: Bevacizumab|DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Association Between Periodontal Disease and Malnutrition in a Group of Elderly People in Thailand.
Status: COMPLETED
Conditions: Periodontal Diseases|Malnutrition
Interventions: BEHAVIORAL: the association between periodontitis and malnutrition status
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Attention Deficit Hyperactivity Disorder
Status: NOT_YET_RECRUITING
Conditions: Attention Deficit Hyperactivity Disorder|Behavior Hyperactive|Behavior Disorders
Interventions: OTHER: Patients suffering from the co-occurrence of ADHD and addiction(s)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Purified Anthocyanins Supplementation and High-Density Lipoprotein (HDL) Function
Status: COMPLETED
Conditions: Diabetes Mellitus，Type 2
Interventions: DIETARY_SUPPLEMENT: Anthocyanin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rapid Evaluation of Pandemic H1N1 Influenza Vaccine in Aboriginal Children and Adults
Status: COMPLETED
Conditions: H1N1/2009 Influenza
Interventions: BIOLOGICAL: Arepanrix|BIOLOGICAL: Arepanrix
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Efficacy and Safety of Votiva for Vaginal Rejuvenation
Status: UNKNOWN
Conditions: Vaginal Atrophy|Vaginal Relaxation|Stress Urinary Incontinence
Interventions: DEVICE: Votiva RF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Doxorubicin in Children With Cancer
Status: COMPLETED
Conditions: Wilms Tumor|Neuroblastoma|Soft Tissue Sarcoma|Acute Lymphoblastic Leukemia
Interventions: DRUG: doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Rocuronium 0.6 mg/kg and Remifentanil 2 µg/kg in Elderly Patients Over 80 Years
Status: COMPLETED
Conditions: Neuromuscular Blockade|Intubation Complication|Anesthesia
Interventions: DRUG: Rocuronium 0.6 mg/kg|DRUG: Remifentanil 2 µg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phenylephrine Versus Ephedrine in Pre-eclampsia
Status: TERMINATED
Conditions: Pre-eclampsia
Interventions: DRUG: Phenylephrine|DRUG: Ephedrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Controlled, Comparative Study of a Levonorgestrel Intrauterine System for the Prevention of Endometrial Cancer in Patients Aged 40-50 With BMI Greater Than 35
Status: TERMINATED
Conditions: Endometrial Cancer
Interventions: DEVICE: Levonorgestrel intrauterine system
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cryoablation Therapy or Radiotherapy Therapy for Stage III Prostate Cancer
Status: UNKNOWN
Conditions: Stage III Prostate Cancer
Interventions: PROCEDURE: Cryoablation therapy|RADIATION: External beam radiation therapy|DRUG: bicalutamide|DRUG: luteinizing-hormone releasing-hormone (LHRH) agonist
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TMC207-C202: Study to Evaluate Bactericidal Activity of Multiple Oral Doses of TMC207 in Subjects With Sputum-Smear Positive Tuberculosis
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: TMC207
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Comparison of Resin-hybrid Ceramic Restorations Produced Using a Computer-aided Design/Computer-aided Manufacturing (CAD/CAM) System With Fiber-reinforced Composite Restorations
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Caries
Interventions: DEVICE: Cerasmart 270 (GC Coop, Tokyo, Japonya)|DEVICE: EverX Flow (GC Coop, Tokyo, Japonya)|DEVICE: : G-CEM ONE (GC Coop, Tokyo, Japonya)|DEVICE: G-Premio Bond (GC Coop, Tokyo, Japonya)|DEVICE: G-ænial A'CHORD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Rivaroxaban or Placebo for Extended Antithrombotic Prophylaxis After Laparoscopic Surgery for Colorectal Cancer.
Status: COMPLETED
Conditions: Prevention of Venous Thromboembolism
Interventions: DRUG: Rivaroxaban|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Association of Clopidogrel Therapy and Stent Thrombosis
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Aspirin monotherapy|DRUG: Aspirin,Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Social Virtual-reality on Enhancing Social Interaction Skills in Children With Attention-deficit/Hyperactivity Disorder
Status: ACTIVE_NOT_RECRUITING
Conditions: Virtual Reality|Social Interaction|Attention-deficit/Hyperactivity Disorder
Interventions: BEHAVIORAL: Virtual reality|BEHAVIORAL: Traditional social skills training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Acute Ethanol Consumption on The Activity of Major Cytochrome P450 Enzymes, NAT2 and P-glycoprotein
Status: COMPLETED
Conditions: AOD Effects and Consequences
Interventions: DRUG: caffeine, tolbutamide, omeprazole, dextromethorphan, digoxin, midazolam single doses|DRUG: ethanol multiple doses plus caffeine, tolbutamide, omeprazole, dextromethorphan, digoxin, midazolam single doses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Advancing DSME/S and COVID-19 Prevention and Protection Through "emPOWERed to Change" Program
Status: WITHDRAWN
Conditions: Type2 Diabetes|Covid19
Interventions: BEHAVIORAL: emPOWERed To Change Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PRasugrEl Monotherapy Following prImary percUtaneous Coronary Intervention for ST-elevation Myocardial Infarction
Status: RECRUITING
Conditions: ST-segment Elevation Myocardial Infarction (STEMI)
Interventions: DRUG: No aspirin (Prasugurel monotherapy)|DRUG: 12-month DAPT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous Progesterone Versus Vaginal Progesterone Gel for Luteal Phase Support
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Subcutaneous progesterone|DRUG: Vaginal progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Soft Tissue Release With and Without Vaginal Dilators on Pain and Sexual Function in Genitio Pelvic Pain
Status: COMPLETED
Conditions: Genito-Pelvic Pain/Penetration Disorder
Interventions: OTHER: soft tissue release|OTHER: vaginal dilators
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LANDMARK Trial: a Randomised Controlled Trial of Myval THV
Status: RECRUITING
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: Myval THV Series|DEVICE: Contemporary Valves (Sapien THV Series and Evolut THV Series)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Intra-articular Platelet-Rich Plasma Injection on The Severity of Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: PRP|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Paragastric Autonomic Blockade to Prevent Visceral Pain After Laparoscopic Sleeve Gastrectomy
Status: COMPLETED
Conditions: Visceral Pain|Bariatric Surgery Candidate|Pain, Postoperative|Vomiting, Postoperative|Nausea, Postoperative
Interventions: PROCEDURE: Paragastric autonomic neural blockade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Effectiveness and Safety of Risperdal CONSTA Added to Usual Treatment in Patients With Bipolar Disorder Who Have Frequent Mood Episodes.
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Risperdal Consta|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer|Advanced Solid Tumor|Metastatic Melanoma|Metastatic Head and Neck Carcinoma|Metastatic Renal Cell Carcinoma|Metastatic Colorectal Cancer|Sarcomas|Metastatic Prostate Cancer|Ovarian Cancer|Small Cell Lung Cancer|Metastatic Breast Cancer|Pancreas Cancer|Gastric Cancer|Esophageal Cancer|Gastroesophageal Junction Adenocarcinoma|Cervical Cancer|Adenoid Cystic Carcinoma|Salivary Gland Cancer|Urothelial Carcinoma
Interventions: DRUG: ONC-392|DRUG: Pembrolizumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic-guided Dosing of Emicizumab
Status: RECRUITING
Conditions: Hemophilia A With Inhibitor|Hemophilia A Without Inhibitor|Hemophilia A, Severe|Adolescent|Child|Adult
Interventions: OTHER: Emicizumab - PK-guided dose reduction|OTHER: Emicizumab - Dosis continuation group|OTHER: Emicizumab - Dose adjustment group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BI 695501 Compared to Adalimumab in Patients With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: BI 695501|DRUG: US-licensed Humira®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Absorption of Budesonide and Formoterol From Budesonide/Formoterol Easyhaler and Symbicort Turbuhaler
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Charcoal and Budesonide/formoterol Easyhaler 320/9 microg|DRUG: Charcoal and Symbicort Turbuhaler|DRUG: Budesonide/formoterol Easyhaler 320/9 microg|DRUG: Symbicort Turbuhaler forte
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Anaerobic Cultivated Human Intestinal Microbiome Transplantation in Systemic Sclerosis (ReSScue)
Status: COMPLETED
Conditions: Systemic Sclerosis
Interventions: DRUG: "ACHIM" as solute (10^9 intestinal microbes/ml)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Implementation of a Digital Intervention for Pediatric Chronic Pain Co-designed With Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Pain
Interventions: BEHAVIORAL: Digital SPA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Remifentanil and Remifentanil-Alfentanil Administration in Children
Status: COMPLETED
Conditions: Adverse Effect of Other General Anesthetics
Interventions: OTHER: Sevoflurane|DRUG: Remifentanil|DRUG: Alfentanil|DRUG: Thiopental|DRUG: Rocuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes of Diet, Physical Activity and Sleep Pattern and Their Effects on Glycemic and Weight Control in Hong Kong Chinese Obese Patients With Type 2 Diabetes After Bariatric Surgery Compared to Telephone Intensive Lifestyle Counselling
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2 in Obese
Interventions: PROCEDURE: Bariatric surgery|BEHAVIORAL: Telephone Intensive Lifestyle Counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Added Sugar Intake on Brain Blood Flow and Hippocampal Function in Midlife Adults
Status: COMPLETED
Conditions: Aging|Healthy Diet
Interventions: OTHER: Low Added Sugar Diet|OTHER: High Added Sugar Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Long Term Study Of Pregabalin In Idiopathic Restless Legs Syndrome Patients
Status: COMPLETED
Conditions: Idiopathic Restless Legs Syndrome
Interventions: DRUG: placebo and pregabalin|DRUG: pramipexol|DRUG: pramipexol|DRUG: Pregabalin|DRUG: pramipexol|DRUG: pramipexol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: STEPuP: Prenatal Provider Education and Training to Improve Medication-assisted Treatment Use During Pregnancy
Status: ENROLLING_BY_INVITATION
Conditions: Opioid-use Disorder|Pregnancy Related
Interventions: BEHAVIORAL: STEPuP Intervention|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study To Investigate Safety, Blood Levels And Effects Of Giving GW642444, By Mouth, By Inhalation & By Injection
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GW642444|DRUG: GW642444|DRUG: GW642444|DRUG: GW642444|DRUG: GW642444|DRUG: GW642444
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Efficacy and Safety of Eryfotona AK-NMSC® in Patients With Actinic Keratosis
Status: UNKNOWN
Conditions: Actinic Keratosis
Interventions: DEVICE: Eryfotona AK-NMSC® cream|OTHER: Sunscreen SPF 50+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Individualized Training to Reduce Fatigue in Patients With Newly and Advanced Diagnosed Multiple Sclerosis
Status: RECRUITING
Conditions: Sclerosis|Fatigue
Interventions: OTHER: Traditional exercise|OTHER: Individualized exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I Study of Safety, Tolerability, and PK of AZD2811 in Patients With Advanced Solid Tumors.
Status: COMPLETED
Conditions: Advanced Solid Tumours
Interventions: DRUG: AZD2811
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Revascularization With BVS or CABG in Patients With Advanced CAD
Status: TERMINATED
Conditions: Multivessel Coronary Artery Disease
Interventions: PROCEDURE: PCI -BVS|PROCEDURE: CABG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Radiological and Patient Reported Outcomes of i-FACTOR+ Matrix Bone Graft Device - A Canadian, Multicenter, Post-Market Clinical Investigation
Status: NOT_YET_RECRUITING
Conditions: Degenerative Disc Disease
Interventions: OTHER: CT radioraphic assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Effect of Treatment With Carbidopa/Levodopa/Entacapone on the Quality of Life of Patients With Parkinson's Disease. This Study is Not Recruiting in the United States
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: carbidopa, levodopa, entacapone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors|Genital Neoplasm, Female|Urogenital Neoplasms|Lung Neoplasm|Neoplasms by Site|Papillomavirus Infection|Epstein-Barr Virus Infections|Carcinoma|Neoplasms|Vulvar Neoplasms|Vulvar Diseases|Abdominal Neoplasm
Interventions: DRUG: STAR0602
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Salmeterol (Serevent®) After Inhalation With Metered Dose Inhaler (MDI) and Diskus® in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Salmeterol Diskus low|DRUG: Salmeterol Diskus high|DRUG: Salmeterol MDI low|DRUG: Salmeterol MDI high
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Menthol for Dyspnea Relief in Health and COPD
Status: RECRUITING
Conditions: Dyspnea|Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Menthol inhalation|OTHER: Strawberry scent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Real-time Videoconference-based Exercise in Eldercare Workers
Status: COMPLETED
Conditions: Pain|Mental Disorders
Interventions: BEHAVIORAL: Real-time videoconference-based Exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Acupressure Applied to Icu on Pain and Physiological Parameters
Status: RECRUITING
Conditions: Intensive Care Patients|Pain
Interventions: OTHER: acupressure|OTHER: placebo acupressure|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Discontinuation of Infliximab Therapy in Patients With Crohn's Disease During Sustained Complete Remission
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DRUG: Infliximab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Nicotine Withdrawal on Reward Responsivity in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: transdermal nicotine patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Capecitabine-based Chemoradiotherapy in Combination With the IL-1 Receptor Antagonist Anakinra for Rectal Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Rectal Cancer
Interventions: DRUG: Kineret 100 MG in 0.67 ML Prefilled Syringe|DRUG: Capecitabine|RADIATION: Radiotherapy|PROCEDURE: Watch and Wait (cCR) or TME surgery (non-cCR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LASER Trial. LAparoscopic Elective Sigmoid Resection Following divERticulitis - a Multicenter, Prospective, Randomized Clinical Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Diverticulum|Colon, Sigmoid
Interventions: PROCEDURE: Elective laparoscopic sigmoid resection|DIETARY_SUPPLEMENT: Conservative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Investigational Pneumococcal Vaccine in Healthy Adults, Toddlers and Infants
Status: COMPLETED
Conditions: Pneumonia|Pneumococcal Infections|Streptococcus Pneumoniae Infections
Interventions: BIOLOGICAL: Pneumococcal Vaccine High Dose (Formulation 1)|BIOLOGICAL: Tris buffered saline (Placebo)|BIOLOGICAL: Pneumococcal Vaccine High Dose (Formulation 1)|BIOLOGICAL: Tris buffered saline (Placebo)|BIOLOGICAL: Pneumococcal Vaccine Low Dose (Formulation 2)|BIOLOGICAL: Tris buffered saline (Placebo)|BIOLOGICAL: Pneumococcal Vaccine Middle Dose (Formulation 3)|BIOLOGICAL: Pneumococcal Vaccine Middle Dose (Formulation 4)|BIOLOGICAL: Tris buffered saline (Placebo)|BIOLOGICAL: Pneumococcal Vaccine High Dose (Formulation 1)|BIOLOGICAL: Tris buffered saline (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Safety and Efficacy of Synvisc and Depo-Medrol in Patients With Osteoarthritis of the Hip
Status: COMPLETED
Conditions: Osteoarthritis, Hip|Musculoskeletal Diseases
Interventions: DEVICE: Synvisc (hylan G-F 20)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Reinforcement Learning in Diabetes Mellitus Trial
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Medication Adherence
Interventions: BEHAVIORAL: Reinforcement Learning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intrauterine Injection of HCG and Implantation Rate
Status: UNKNOWN
Conditions: Pregnancy Rate|Implantation Rate
Interventions: DRUG: HCG injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Nexium and Probiotics on Insulin Secretion and Cardiovascular Risk Factors in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: nexium|DRUG: nexium|DIETARY_SUPPLEMENT: Yoghurt|DRUG: placebo+placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Community Based Intervention to Prevent Domestic Violence Against Women in Ethiopia; a Protocol for Quasi-Experimental Implementation Research
Status: UNKNOWN
Conditions: Domestic Violence Against Women|Community-based Prevention|Interevntion Implementation
Interventions: BEHAVIORAL: Intervention 1: Comprehensive preventive intervention|BEHAVIORAL: Intervention 2: Awareness creation and community mobilization|OTHER: available standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: BREATHE: An Efficacy-implementation Trial Among Black Adults With Uncontrolled Asthma
Status: RECRUITING
Conditions: Asthma
Interventions: BEHAVIORAL: BREATHE Intervention|BEHAVIORAL: Control Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cross Fiber Fascial Manipulation and Stretching Techniques in Overhead Throwing Athletes
Status: RECRUITING
Conditions: Overhead Throwing Athletes|Tennis Players, Bowlers, Volleyball Players
Interventions: OTHER: cross fiber fascial manipulation|OTHER: stretching techniques(sleeper stretch and cross body adduction stretch)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT