pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNF Agents.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: rituximab [MabThera/Rituxan]|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Digital Patient Decision Aid to Increase Sexually Transmitted Infection Testing in the Emergency Department: The STIckER Study
Status: RECRUITING
Conditions: STI|Sexually Transmitted Infection (STI)|Sexually Transmitted Disease (STD)
Interventions: BEHAVIORAL: STIckER|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Trial Evaluating the Effect of Facilitated Small Group Sessions on Physician Well-Being, Job Satisfaction, and Professionalism
Status: COMPLETED
Conditions: Physician Well-being|Physician Job Satisfaction
Interventions: BEHAVIORAL: Facilitated small groups|BEHAVIORAL: Unstructured time.|BEHAVIORAL: Usual practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Protein Supplementation and a Structured Exercise Program on Muscle in Women After Bariatric Surgery.
Status: COMPLETED
Conditions: Sarcopenic Obesity|Bariatric Surgery Candidate|Nutritional Deficiency|Protein Intolerance
Interventions: DIETARY_SUPPLEMENT: Protein Supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 2 Week Blinded Study For Pain Due To Arthritis Of The Knee
Status: TERMINATED
Conditions: Osteoarthritis
Interventions: DRUG: Oxycodone|DRUG: Placebo|DRUG: PF-000592379
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Disentangling Pharmacological and Expectation Effects in Antidepressant Discontinuation
Status: RECRUITING
Conditions: Depressive Symptoms|Expectations|Antidepressants
Interventions: DRUG: Treatment 'discontinuation of antidepressant medication'|DRUG: Treatment 'continuation of antidepressant medication'|BEHAVIORAL: Expectation 'high'|BEHAVIORAL: Expectation 'moderate'
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Diagnostic Accuracy Comparison Between Telemedicine and Face-to-face Consultations in Respiratory Infection Patients.
Status: COMPLETED
Conditions: Respiratory Tract Infections
Interventions: OTHER: Telemedicine Consultation|OTHER: Face-to-face Consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Timing of Transcutaneous Acupoint Electrical Stimulation on Postoperative Recovery in Geriatric Patients With Gastrointestinal Tumor
Status: NOT_YET_RECRUITING
Conditions: Postoperative Cognitive Dysfunction
Interventions: OTHER: Transcutaneous acupoint electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Affordability and Real-world Antiplatelet Treatment Effectiveness After Myocardial Infarction Study
Status: COMPLETED
Conditions: Cost Sharing, Acute Coronary Syndrome
Interventions: OTHER: Study voucher card
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Shoulder Pain and Post Gynecologic Laparoscopic Recovery
Status: COMPLETED
Conditions: Gynecologic Nursing|Postoperative Pain
Interventions: OTHER: Trendelenburg Position|OTHER: Warm Pad Application|BEHAVIORAL: Deep Breathing Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Spinal Anesthesia Versus General Anesthesia Using Laryngeal Mask Airway for Anorectal Surgeries in Prone Position
Status: COMPLETED
Conditions: Anesthesia|Anorectal Surgery
Interventions: PROCEDURE: Spinal Anesthesia for Anorectal Surgeries in Prone Position|PROCEDURE: General Anesthesia Using Laryngeal Mask Airway for Anorectal Surgeries in Prone Position
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluating a Knowledge Translation Tool for Parents
Status: COMPLETED
Conditions: Acute Gastroenteritis|Pediatric ALL|Knowledge Translation
Interventions: BEHAVIORAL: Whiteboard animation video|BEHAVIORAL: Regular video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Home-based Visual-motor Training Program on Kindergarteners
Status: NOT_YET_RECRUITING
Conditions: Developmental Delay|Preterm Children
Interventions: BEHAVIORAL: Traditional visual-motor training program|BEHAVIORAL: Computerized visual-motor training program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Assess Diets Containing Beef vs. Poultry on Pancreatic Beta-Cell Function
Status: COMPLETED
Conditions: PreDiabetes
Interventions: OTHER: Beef|OTHER: Poultry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Supporting Post Myocardial Infarction (MI) Risk Modification Intervention Via Telemedicine Evaluation
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: BEHAVIORAL: web intervention|BEHAVIORAL: nurse intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Photorefractive Keratectomy (PRK) : Comparison of Corneal Haze Between Two Modes of De-epithelialisation (Laser Versus Manual Alcohol)
Status: RECRUITING
Conditions: Myopia|Astigmatism
Interventions: PROCEDURE: TransPRK|PROCEDURE: Alcohol PRK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Indocyanine Green Fluorescence Imaging in Prevention of Colorectal Anastomotic Leakage
Status: RECRUITING
Conditions: Colorectal Cancer|Colorectal Neoplasms|Gastrointestinal Cancer|Gastrointestinal Neoplasms|Diverticulosis, Colonic|Gastrointestinal Disease
Interventions: DEVICE: ICG fluorescence imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase IIa Study of AV411, a Glial Activation Inhibitor, for Opioid Withdrawal
Status: COMPLETED
Conditions: Opioid-Related Disorders
Interventions: DRUG: AV411|DRUG: Placebo (PCB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nickel Desensitization Using Topical Therapy
Status: UNKNOWN
Conditions: Allergic Contact Dermatitis
Interventions: DRUG: Calcipotriol, Betamethasone, Calcipotriol & Betamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Cognitive Risk Calculator and Screening Tool for Primary Care Settings
Status: ENROLLING_BY_INVITATION
Conditions: Cognitive Risk Assessment
Interventions: BEHAVIORAL: Implementation of Cognitive Risk Calculator (RC) and Brief Assessment of Cognitive Health (BACH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy of Lenvatinib (E7080/MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma (MK-7902-012/E7080-G000-318/LEAP-012)
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Lenvatinib|BIOLOGICAL: Pembrolizumab|DRUG: Oral Placebo|DRUG: IV Placebo|PROCEDURE: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Efficacy of Visible Light-Ultraviolet A1 Light Versus Narrowband-Ultraviolet B on Generalized Vitiligo
Status: TERMINATED
Conditions: Generalized Vitiligo
Interventions: PROCEDURE: Visible Light-Ultraviolet A Light or Narrowband-Ultraviolet B phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Exergames and Resistance Training
Status: RECRUITING
Conditions: Frailty|Sacropenia|Cognition|Mood|Mobility
Interventions: OTHER: exergames and resistance training|OTHER: Resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Gefitinib Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Gefitinib Tablet 250mg of Hunan Kelun|DRUG: Iressa® Tablet 250mg of AZN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of the Effect of Daridorexant on Nighttime Body Posture, the Noise Level Required to Wake up, and the Ability to Remember Words Previously Presented
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Daridorexant 25 mg|DRUG: Daridorexant 50 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Heated Humidity With Thermosmart™ Compared to an Intranasal Steroid in Improving Compliance and Nasal Symptoms in Patients Using Continuous Positive Airway Pressure
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Nasal Congestion|Sinus Congestion
Interventions: DRUG: Thermosmart & placebo|DRUG: Placebo Device & Nasacort|DEVICE: Placebo Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Small Change Approach to Preventing Long Term Weight Gain in Overweight and Obese Adults
Status: COMPLETED
Conditions: Obesity|Prevention of Weight Gain
Interventions: BEHAVIORAL: Control group|BEHAVIORAL: Lifestyle counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SS-HH-OCT as a Novel Diagnostic Modality for Early-Onset Retinal Dystrophies (EORDs)
Status: RECRUITING
Conditions: Retinal Dystrophies
Interventions: DEVICE: SS-HH-OCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Extension Study of Intrathecal Enzyme Replacement for Cognitive Decline in MPS I
Status: TERMINATED
Conditions: Mucopolysaccharidosis I|Cognitive Decline
Interventions: DRUG: Intrathecal recombinant human alpha iduronidase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Initiation of Home Mechanical Ventilation at Home in Patients With Chronic Hypercapnic Respiratory Failure
Status: COMPLETED
Conditions: Respiratory Therapy|Respiration, Artificial|Positive-Pressure Respiration|Neuromuscular Diseases|Noninvasive Ventilation|Cost-Benefit Analysis|Ambulatory Monitoring
Interventions: PROCEDURE: Initiation of mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of Altered Waking States of Consciousness in Healthy Humans
Status: COMPLETED
Conditions: Altered Waking States of Consciousness in Healthy Humans
Interventions: OTHER: TMS/EEG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy/ Safety of Product CM9241GRU in Patients With Perennial Allergic Rhinitis
Status: NOT_YET_RECRUITING
Conditions: Rhinitis, Allergic, Perennial
Interventions: DRUG: Product CM9241GRU|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Ballistic Six Exercises With and Without Blood Flow Restriction in Cricket Players
Status: RECRUITING
Conditions: Plyometric Exercise|Blood Flow Restriction Training
Interventions: OTHER: Plyometric Exercises|OTHER: Blood Flow Restriction Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Hybrid-sensor Breath Analysis for Colorectal Cancer Screening
Status: UNKNOWN
Conditions: Colorectal Cancer|Polyp of Colon
Interventions: PROCEDURE: Identification of specific VOCs in CRC tissue surgery material|OTHER: Secondary validation study in general CRC screening settings|DEVICE: Breath sampling for VOC detection|OTHER: Blood sample collection|DIAGNOSTIC_TEST: Microbiota testing|DIAGNOSTIC_TEST: Colonoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase I/II Study of SyB L-0501RI in Combination With Rituximab to Treat Lymphoma
Status: COMPLETED
Conditions: Lymphoma, B-cell, Diffuse
Interventions: DRUG: SyB L-0501RI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Relaxation Training on Primary Dysmenoreh and Menstrual Symptoms
Status: COMPLETED
Conditions: Menstrual Discomfort|Relaxation Abnormality|Dysmenorrhea Primary
Interventions: OTHER: relaxation techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Blood Pressure Target in Acute Stroke to Reduce hemorrhaGe After Endovascular Therapy
Status: COMPLETED
Conditions: Acute Stroke|Blood Pressure|Cerebral Hemorrhage
Interventions: OTHER: Systolic blood pressure target < 130 mm Hg|OTHER: Systolic blood pressure target < 185 mm Hg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 2a Study to Evaluate the Safety and Efficacy of AZX100 in Trocar Sites of Arthroscopic Shoulder Surgery Patients
Status: COMPLETED
Conditions: Scar Prevention|Scar Reduction
Interventions: DRUG: Placebo|DRUG: AZX100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase II Study of H56:IC31 in Healthy Adolescents
Status: WITHDRAWN
Conditions: Tuberculosis Infection
Interventions: BIOLOGICAL: H56:IC31|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: An Efficacy and Safety Study of Mitiperstat (AZD4831) (MPO Inhibitor) vs Placebo in the Treatment of Moderate to Severe COPD.
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Mitiperstat (AZD4831)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Remind-to-move" for Promoting Upper Extremity Recovery in Patients With Stroke After Subacute Discharge
Status: COMPLETED
Conditions: Stroke|Upper Extremity Hemiplegia
Interventions: BEHAVIORAL: Remind-to-move|BEHAVIORAL: Sham|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Modakafusp Alfa Together With Daratumumab Adults With Relapsed or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Modakafusp Alfa|DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GP Chemotherapy in Combination With Tislelizumab and Ociperlimab as First-line Treatment in Advanced BTC
Status: WITHDRAWN
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DRUG: GP+PD-1+Tight
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gallium Ga 68-labeled PSMA-11 PET/CT and Fluciclovine F18 PET/CT in Imaging Participants With Recurrent Prostate Cancer After Surgery
Status: COMPLETED
Conditions: Recurrent Prostate Carcinoma
Interventions: PROCEDURE: Computed Tomography|DRUG: Fluciclovine F18|DRUG: Gallium Ga 68-labeled PSMA-11|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Letrozole and Sequential Clomiphene to Improve the Outcome of Embryo Transfer
Status: UNKNOWN
Conditions: Female Infertility Due to Nonimplantation of Ovum
Interventions: DRUG: Letrozole|DRUG: clomiphene|DRUG: HMG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Nephrogreen. Appearances of Exvivo Renal Tumours Under Near-infrared
Status: NOT_YET_RECRUITING
Conditions: Wilms Tumor|Renal Cancer
Interventions: DIAGNOSTIC_TEST: Indocyanine Green (ICG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I Clinical Trial of PCV24 in Adults
Status: NOT_YET_RECRUITING
Conditions: Pneumococcal Infectious Disease
Interventions: BIOLOGICAL: Sinovac PCV24 formulation 1|BIOLOGICAL: Sinovac PCV24 formulation 2|BIOLOGICAL: Pneumovax®|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mindfulness Versus Pharmacotherapy for Chronic Insomnia: A Pilot Study
Status: COMPLETED
Conditions: Chronic Insomnia|Primary Insomnia
Interventions: BEHAVIORAL: Mindfulness-Based Stress Reduction|DRUG: eszopiclone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Topical Skin Adhesive to Subcuticular Suture Closure of Implantable Port Incisions
Status: COMPLETED
Conditions: Port-A-Cath Placement|Octylcyanoacrylate
Interventions: DEVICE: Octylcyanoacrylate|PROCEDURE: Suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selective Retina Therapy (SRT) in Patients With Idiopathic Central Serous Retinopathy
Status: COMPLETED
Conditions: Central Serous Chorioretinopathy|Selective Retina Therapy
Interventions: DEVICE: Selective Retina Therapy (SRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy and Safety of ATB-1011+ATB-1012 Co-administration for Essential Hypertension and Type II Diabetes
Status: RECRUITING
Conditions: Essential Hypertension|Diabetes Mellitus, Type 2
Interventions: DRUG: ATB-1011|DRUG: ATB-1012|DRUG: ATB-1013|DRUG: ATB-1011 placebo|DRUG: ATB-1012 placebo|DRUG: ATB-1013 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Portal Vein Stenting in Patients With Portal Vein Stenosis and Gastrointestinal Cancers
Status: RECRUITING
Conditions: Malignant Digestive System Neoplasm
Interventions: OTHER: Electronic Health Record Review|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence Study of Two Formulations of Pregabalin Capsules 150 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pregabalin capsules 150 mg of Dexa Medica|DRUG: Pregabalin capsules 150 mg of Pfizer Manufacturing Deutschland
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound and Attenuation Imaging
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease|Non Alcoholic Fatty Liver|Non-alcoholic Steatohepatitis|Steatosis of Liver
Interventions: DEVICE: Ultrasound Attenuation imaging measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Acupuncture for Prophylaxis of Intrathecal Morphine Induced Pruritis in Patients Undergoing Caesarean Delivery
Status: COMPLETED
Conditions: Acupuncture|Morphine Induced Pruritis
Interventions: DEVICE: ACUPUNCTURE AT LI11|DEVICE: SHAM ACUPUNCTURE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: At the Heart of the Matter - Speckle Tracking Echocardiography in Lupus Mothers and Their Offspring
Status: UNKNOWN
Conditions: Systemic Lupus Erythematosus|Placenta-mediated Pregnancy Complications|Hydroxychloroquine|Speckle Tracking Echocardiography|Cardiovascular Morbidity|Cardiovascular Diseases|Cardiovascular Complication|Pregnancy Complications
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: NBI-3001 Followed by Surgery in Treating Patients With Recurrent Glioblastoma Multiforme
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: BIOLOGICAL: interleukin-4 PE38KDEL cytotoxin|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: 68Ga-pentixather and 68Ga-pentixafor PET/CT in Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: 68Ga-Pentixather|DRUG: 68Ga-Pentixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (MRI Part)
Status: NOT_YET_RECRUITING
Conditions: Carotid Endarterectomy
Interventions: DRUG: Ephedrine|DRUG: Phenylephrine|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Increasing the Oral Bioavailability of 6-prenylnaringenin by Micellar Solubilization
Status: COMPLETED
Conditions: Safety of Native vs. Micellar 6-PN After Oral Intake|Pharmacokinetics of Native vs. Micellar 6-PN After Oral Intake|PBMC Activity After Native vs. Micellar 6-PN Oral Intake
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Native 6-prenylnaringenin|DIETARY_SUPPLEMENT: Micellar 6-prenylnaringenin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Silicone Adhesive Multilayer Foam Dressings to Prevent Pressure Ulcer
Status: COMPLETED
Conditions: Pressure Ulcer
Interventions: DEVICE: Allevyn® brand silicone adhesive multilayer foam dressings|DEVICE: Mepilex® brand silicone adhesive multilayer foam dressings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Allogeneic Myeloma GM-CSF Vaccine With Lenalidomide in Multiple Myeloma Patients in Complete or Near Complete Remission
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: GM-CSF vaccine|DRUG: Lenalidomide|DRUG: Prevnar13|OTHER: Placebo Prevnar13|OTHER: Placebo GM-CSF Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ivabradine for Long-Term Effects of COVID-19 With POTS Cohort
Status: RECRUITING
Conditions: Long Haul COVID|Postural Orthostatic Tachycardia Syndrome
Interventions: DRUG: Ivabradine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Intervention at the End of Therapy for Survivors of Childhood ALL Treated on TOTXVI
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: BEHAVIORAL: Cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The CANTATA-D Trial (CANagliflozin Treatment and Trial Analysis - DPP-4 Inhibitor Comparator Trial)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo|DRUG: Canagliflozin|DRUG: Sitagliptin|DRUG: Metformin immediate release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ablation for ICD Intervention Reduction in Patients With CAD
Status: TERMINATED
Conditions: Ventricular Tachycardia|Coronary Artery Disease|Implantable Cardioverter-Defibrillator
Interventions: PROCEDURE: ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: L-carnosine for Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: L-carnosine (dietary supplement)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Intradialytic Hypotension by Inhibiting Bradykinin B2 Receptor
Status: RECRUITING
Conditions: Intradialytic Hypotension
Interventions: DRUG: Icatibant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: TAP-patients With Robotic Assisted Lap Prostatectomy
Status: COMPLETED
Conditions: Postsurgical Pain|Analgesia|Prostatectomy
Interventions: DRUG: EXPAREL 20 mL|DRUG: EXPAREL 40 mL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TMC649128HPC1001 - First In-human Trial to Examine Safety, Tolerability, and Pharmacokinetics (How the Drug is Absorbed Into the Bloodstream) of Increasing Single Oral Doses of TMC649128 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: TMC649128
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 18F-FSPG PET in Imaging Patients With Liver Cancer Before Undergoing Surgery or Transplant
Status: RECRUITING
Conditions: Adult Hepatocellular Carcinoma|Resectable Hepatocellular Carcinoma|Cholangiocarcinoma|Benign Liver Tumor|Metastases to Liver
Interventions: BIOLOGICAL: Fluorine F 18 L-glutamate Derivative 18F-FSPG|BIOLOGICAL: Carbon C 11 Acetate|PROCEDURE: Positron Emission Tomography|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Fluorine F 18 2-deoxy-2-(18F)fluoro-D-glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Extension Trial of Inclisiran in Participants With Cardiovascular Disease and High Cholesterol
Status: COMPLETED
Conditions: Atherosclerotic Cardiovascular Disease|Symptomatic Atherosclerosis|Type2 Diabetes|Familial Hypercholesterolemia
Interventions: DRUG: Inclisiran|DRUG: Evolocumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assess Bioequivalence of One 150 mg Risedronate Tablet Versus Two 75 mg Risedronate Tablets in Healthy Subjects
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Risedronate|DRUG: Risedronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Post-marketing Research on Jinyebaidu Granule in Treating Patients With Acute Upper Respiratory Infection
Status: UNKNOWN
Conditions: Acute Upper Respiratory Infection
Interventions: DRUG: Jinyebaidu granule|DRUG: Fufangshuanghua granule|DRUG: Jinyebaidu granule placebo|DRUG: Fufangshuanghua granule placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Single Dose Tadalafil on Urethral and Anal Closure Function
Status: COMPLETED
Conditions: Urinary Incontinence,Stress|Fecal Incontinence
Interventions: DRUG: Tadalafil 40 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nab-Paclitaxel, Cisplatin, and Cetuximab With Concurrent Radiation Therapy for Locally Advanced Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: Cetuximab|DRUG: Cisplatin|DRUG: Nab-Paclitaxel|RADIATION: intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PMRR-NO: Pulmonary Metabolic Radiation Response Versus Exhaled Nitric Oxide
Status: COMPLETED
Conditions: Gastrointestinal Disease|Esophageal Cancer|Lung Cancer
Interventions: PROCEDURE: Breathing Test|BEHAVIORAL: Respiratory Symptoms Questionnaire|PROCEDURE: Pet Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study of Nerve Reconstruction Using AVANCE in Subjects Who Undergo Robotic Assisted Prostatectomy for Treatment of Prostate Cancer
Status: COMPLETED
Conditions: Peripheral Nerve Injury|Prostate Cancer|Radical Prostatectomy|Nerve Reconstruction|Cavernous Nerve Injury
Interventions: OTHER: Processed Human Nerve Tissue Scaffold
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Internet-Based Intervention On Hypertensive Patients With Overweight Or Obesity
Status: COMPLETED
Conditions: Hypertension|Obesity
Interventions: BEHAVIORAL: Experimental group|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety of a Monovalent Vaccine of a New 6:2 Reassortant in Healthy Adults (AV024)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: AV024|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Treadmill Training With Visual Feedback and Rhythmic Auditory Cue on Gait and Balance in Cerebral Palsy
Status: COMPLETED
Conditions: Hemiplegic Cerebral Palsy
Interventions: OTHER: Visual Feedback and Rhythmic Auditory Cue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Value of Hybrid PET/MR and PET/CT in Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer|PET/MR|PET/CT
Interventions: DIAGNOSTIC_TEST: 68Ga-PSMA-11 and/or 18F-FDG PET/MR, PET/CT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluate Effects of Personalized Patient Counselling for Enbrel® Therapy in Adults With Rheumatoid Arthritis
Status: TERMINATED
Conditions: Persistence to Enbrel
Interventions: BEHAVIORAL: Personalized Patient Counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Product Performance of a New Silicone Hydrogel Multifocal Contact Lens
Status: COMPLETED
Conditions: Myopia and Hyperopia and Presbyopia
Interventions: DEVICE: new silicone hydrogel daily disposable multifocal contact lens, the Bausch + Lomb (kalifilcon A) Daily Disposable Multifocal Contact Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-component Intervention for Diabetes in Adults With Serious Mental Illness
Status: UNKNOWN
Conditions: Schizophrenia|Obesity|Diabetes|Lifestyle Risk Reduction|Serious Mental Illness
Interventions: BEHAVIORAL: Multi-component Intervention for Diabetes in Adults with Serious Mental Illness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Post-operative Analgesic Effects of Dexamethasone Added to Bupivacaine in Transversusabdominis Plane (TAP) Block
Status: COMPLETED
Conditions: Postoperative Analgesia
Interventions: DRUG: Dexamethasone|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: GM-CLAG in Relapsed/Refractory FLT3-mutated AML
Status: WITHDRAWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Gilteritinib 40 MG Oral Tablet|DRUG: Cladribine|DRUG: Cytarabine|DRUG: Filgrastim|DRUG: Mitoxantrone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: At-home Breast Oncology Care Delivered With E-health Solutions
Status: RECRUITING
Conditions: Patient Engagement|Patient Activation|Patient Reported Outcome Measures
Interventions: OTHER: At-home Breast Oncology care Delivered with E-health solutions - ABODE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of Sedation Depth in ARDS Patients Undergoing Therapeutic Paralysis
Status: ACTIVE_NOT_RECRUITING
Conditions: Sedation Complication|Acute Respiratory Distress Syndrome Due to COVID-19|Anesthesia Awareness
Interventions: PROCEDURE: Depth of sedation monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Epacadostat (INCB024360) in Combination With Durvalumab (MEDI4736) in Subjects With Selected Advanced Solid Tumors (ECHO-203)
Status: COMPLETED
Conditions: Solid Tumors|Head and Neck Cancer|Lung Cancer|UC (Urothelial Cancer)
Interventions: DRUG: MEDI4736|DRUG: INCB024360
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Organ Transplant Recipient HPV and Skin Cancer Study
Status: RECRUITING
Conditions: Solid Organ Transplant Recipient|Skin Cancer|Skin Dysplasia|HPV Infection|Cervical Intraepithelial Neoplasia|Cervical Cancer|HPV-Related Malignancy
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Early Minimally Invasive Image Guided Endoscopic Evacuation of Intracerebral Haemorrhage
Status: COMPLETED
Conditions: Intracerebral Hemorrhage (ICH)
Interventions: PROCEDURE: hematoma evacuation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in MarginalzoneLymphoma A MULTICENTER OPEN LABEL SINGLE-ARM PHASE II STUDY
Status: RECRUITING
Conditions: Marginal Zone Lymphoma
Interventions: DRUG: Rituximab|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mirvetuximab Soravtansine as First Line in Treating Patients With Triple Negative Breast Cancer
Status: COMPLETED
Conditions: Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Estrogen Receptor Negative|Folate Receptor Alpha Positive|HER2/Neu Negative|Progesterone Receptor Negative|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8|Prognostic Stage IV Breast Cancer AJCC v8|Triple-Negative Breast Carcinoma
Interventions: BIOLOGICAL: Mirvetuximab Soravtansine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: QTX3034 in Patients With KRAS G12D Mutation
Status: RECRUITING
Conditions: Solid Tumors
Interventions: DRUG: QTX3034|COMBINATION_PRODUCT: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hematopoietic Stem Cell Support in Patients With Severe Crohn's Disease
Status: TERMINATED
Conditions: CROHN'S DISEASE
Interventions: BIOLOGICAL: Immune Ablation and Hematopoietic Stem Cell Support
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient Education and Use of Post Operative Pain Medication in Ambulatory Hand Surgery: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Ambulatory Hand Surgery
Interventions: BEHAVIORAL: Patient education regarding indications for opioid use and side effects of opioid use after hand surgery|OTHER: Standard of care post-operative counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Comparison Between Elliptical Domed Mesh Technique and Lichtenstein Technique in Inguinal Hernia
Status: UNKNOWN
Conditions: Inguinal Hernia
Interventions: PROCEDURE: Elliptical domed mesh technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adoption of Audio Recording in the Outpatient Supportive Care Center
Status: NOT_YET_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Hematopoietic and Lymphoid Cell Neoplasm|Locally Advanced Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm|Recurrent Malignant Solid Neoplasm
Interventions: OTHER: Communication Intervention|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Extended Safety Study of Tenofovir Disoproxil Fumarate (TDF) Among HIV-1 Negative Men
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: tenofovir disoproxil fumarate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study in Healthy Women to Test Whether BI 425809 Influences the Amount of a Contraceptive in the Blood
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Microgynon®|DRUG: BI 425809
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cannabinoid Profile Investigation of Vapourized Cannabis in Patients With Osteoarthritis of the Knee
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Cannabis|DEVICE: Volcano® Medic Vapourizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigational Study of Oral Fish Oil in Treating Parenteral Nutrition Associated Liver Disease
Status: WITHDRAWN
Conditions: Liver Disease|Short Bowel Syndrome
Interventions: DRUG: Lovaza (omega-3-acid ethyl ester)|DIETARY_SUPPLEMENT: Corn oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quadricipital Electrical Stimulation in COPD Patients Rehabilitation
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: group 2 : quadricipital electrical stimulation|OTHER: pulmonary rehabilitation|DEVICE: muscular electrical stimulation|OTHER: pulmonary rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dispensing Evaluation of Printed Etafilcon A With Polyvinylpyrrolidone (PVP)
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: etafilcon A (A)|DEVICE: etafilcon A (B)|DEVICE: etafilcon A (C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Heparin in Patients With Severe Sepsis Who Are Undergoing Treatment With Drotrecogin Alfa (Activated)
Status: COMPLETED
Conditions: Sepsis
Interventions: DRUG: Drotrecogin Alfa (Activated)|DRUG: Unfractionated heparin|DRUG: Low molecular weight heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Abraxane and Gemicitabine in Patients With Advanced Adenocarcinoma Non-Small Cell Lung Cancer Progressing After First-Line Platinum-Based Chemotherapy
Status: COMPLETED
Conditions: Patients With Stage IV or Recurrent Adenocarcinoma of the Lung
Interventions: DRUG: Abraxane|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Dexmedetomidine vs Midazolam for Early Extubation in Critically Ill Agitated Patients Undergoing Weaning
Status: NOT_YET_RECRUITING
Conditions: Agitation, Emergence
Interventions: DRUG: Dexmedetomidine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study 767905/008 Extension Study: Alvimopan for Treatment of Opioid-Induced Bowel Dysfunction in Cancer Pain Subjects
Status: COMPLETED
Conditions: Cancer|Bowel Dysfunction
Interventions: DRUG: alvimopan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy
Status: COMPLETED
Conditions: Coats' Disease|Idiopathic Retinal Telangiectasia|Retinal Angiomatous Proliferation|Polypoidal Choroidal Vasculopathy|Pseudoxanthoma Elasticum|Pathological Myopia|Multi-focal Choroiditis|Rubeosis Iridis|Von Hippel Lindau Disease|BEST VITELLIFORM MACULAR DYSTROPHY, MULTIFOCAL (Disorder)
Interventions: DRUG: ranibizumab injection (0.5 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of C13-CAC Breath Test in PPI Resistant GERD Patients
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: Calcium (13C)Carbonate|DRUG: Gastric acid inhibitors|OTHER: Gastric pH monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Examine the Safety and Tolerability of MK0517 for the Prevention of Post-Operative Nausea and Vomiting (0517-015)
Status: COMPLETED
Conditions: Post-Operative Nausea and Vomiting
Interventions: DRUG: Comparator: MK0517|DRUG: Comparator: ondansetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Natrunix in HLA-B27 Positive Subjects With Axial Spondyloarthritis
Status: NOT_YET_RECRUITING
Conditions: Axial Spondyloarthritis
Interventions: DRUG: Natrunix|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Genetic Testing and Phenotypic Characterization of Severely Obese Pediatric and Adult Volunteers
Status: COMPLETED
Conditions: Pro-opiomelanocortin (POMC), Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) and Leptin Receptor (LepR) Gene Mutations
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Immune Response Against the Strain of Neisseria Meningitidis B: 14, P1-7, 16 Patients Vaccinated With MenBVac® (Extension MenbVac)
Status: COMPLETED
Conditions: Vaccination With MenbVac
Interventions: BIOLOGICAL: MenbVac
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH