pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Home-based Growth Charts in Indonesia
Status: COMPLETED
Conditions: Child Growth
Interventions: OTHER: Home-based growth charts|OTHER: Home visits for baseline surveys|OTHER: Home visits for end line surveys|OTHER: Measurement of child's height-for-age and weight-for-age
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Oral Antibiotics for Anal Abscess
Status: RECRUITING
Conditions: Anal Fistula|Anal Abscess
Interventions: DRUG: ANTIBIOTIC (METRONIDAZOLE AND CIPROFLOXACIN)|OTHER: CONTROL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Simmitecan Hydrochloride in the Treatment of Advanced Solid Tumor
Status: COMPLETED
Conditions: Advanced Solid Tumor
Interventions: DRUG: Simmitecan Hydrochloride for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Prostatodynia in Younger Patients With Non-ablative Erbium:YAG Intraurethral Laser
Status: COMPLETED
Conditions: Chronic Prostatitis With Chronic Pelvic Pain Syndrome|Prostatodynia
Interventions: DEVICE: non-ablative SMOOTH mode Erbium YAG laser|DRUG: Tadalafil 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GS-5885, GS-9451, Tegobuvir and Ribavirin (RBV) in Interferon Ineligible or Intolerant Subjects With Chronic Genotype 1a or 1b Hepatitis C Virus (HCV) Infection
Status: COMPLETED
Conditions: Chronic Genotype 1a or 1b HCV Infection
Interventions: DRUG: GS-5885 tablet|DRUG: GS-9451 tablet|DRUG: tegobuvir capsule|DRUG: ribavirin tablet|DRUG: placebo matching ribavirin tablet|DEVICE: placebo matching tegobuvir capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cell-free Stem Cell-derived Extract Formulation for Knee Osteoarthritis
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: BIOLOGICAL: Cell-free Stem Cell-derived Extract Formulation (CCM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SupportBP 2.0:Behavioral Science and Enrollment in Remote Monitoring for Hypertension Management
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: Opt-In Recruitment|BEHAVIORAL: Opt-Out Recruitment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Topical Aqueous Suppressants on Intraocular Gas Duration Following Pars Plana Vitrectomy
Status: COMPLETED
Conditions: Macular Hole|Retinal Detachment
Interventions: DRUG: Dorzolamide 2%-timolol 0.5% topical eyedrops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel, Capecitabine, and Bevacizumab in Treating Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: capecitabine|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Programmed Intermittent Epidural Bolus for Labor Analgesia During First Stage of Labor: Comparing 125 mL/h Versus 250 mL/h Bolus Delivery Flow
Status: COMPLETED
Conditions: Labor Pain
Interventions: DEVICE: CADD-Solis Ambulatory Infusion System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Premarking of Axillary Nodes Before Start of Neoadjuvant Chemotherapy Using Magnetic Approach
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: MagTrace only|COMBINATION_PRODUCT: MagTrace and Magseed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of the Olfactory Stimulation on the People With Mild Dementia Via the Horticultural Therapy
Status: COMPLETED
Conditions: Dementia
Interventions: OTHER: board game comparison|OTHER: olfactory stimulation intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study Comparing Standard FBT and Guided Self-Help FBT for Adolescent Anorexia Nervosa
Status: COMPLETED
Conditions: Anorexia Nervosa
Interventions: BEHAVIORAL: Guided Self-Help for Family Based Treatment|BEHAVIORAL: Family Based Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Sofosbuvir in People With Advanced Kidney Failure
Status: COMPLETED
Conditions: Kidney Failure, Chronic|Hepatitis C
Interventions: DRUG: Sofosbuvir|DRUG: Daclatasvir 60 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of the Effects of Mental Practice on Tongue Strength in Brain-damaged Patients
Status: UNKNOWN
Conditions: Movement, Involuntary
Interventions: BEHAVIORAL: Action observation|BEHAVIORAL: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Adaptive Support Ventilation vs. Volume Controlled Ventilation for Management of Respiratory Failure in Patients With Neuroparalytic Snake Envenomation
Status: COMPLETED
Conditions: Snake Envenomation|Invasive Mechanical Ventilation|Adaptive Support Ventilation
Interventions: OTHER: Adaptive support ventilation|OTHER: Volume controlled ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Symptom Tracking, Patient Engagement and Quality of Life in Advanced Cancer
Status: ENROLLING_BY_INVITATION
Conditions: Quality of Life
Interventions: DEVICE: Use of Noona web- based symptom tracking tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer)
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Atezolizumab|DRUG: Cobimetinib|DRUG: RO6958688|DRUG: Docetaxel|DRUG: CPI-444|DRUG: Pemetrexed|DRUG: Carboplatin|DRUG: Gemcitabine|DRUG: Linagliptin|DRUG: Tocilizumab|DRUG: Ipatasertib|DRUG: Bevacizumab|DRUG: Sacituzumab Govitecan|OTHER: Radiation|DRUG: Evolocumab|DRUG: Tiragolumab|DRUG: XL092|DRUG: Camonsertib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2a to Assess the Safety and Tolerability of TP-122A for the Treatment of Ventilator-Associated Pneumonia
Status: NOT_YET_RECRUITING
Conditions: Pneumonia, Ventilator-Associated
Interventions: BIOLOGICAL: TP-122A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Athermal Nerve-sparing During Robotic-assisted Radical Prostatectomy Using a Hemostatic Matrix.
Status: UNKNOWN
Conditions: Prostate Cancer|Erectile Dysfunction
Interventions: PROCEDURE: Application of a hemostatic gelatin-thrombin matrix|PROCEDURE: Use of mono- and bipolar electrocautery and surgical clips
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability Study of TAK-583 in Subjects With Postherpetic Neuralgia
Status: COMPLETED
Conditions: Neuralgia, Postherpetic
Interventions: DRUG: TAK-583|DRUG: TAK-583|DRUG: TAK-583|DRUG: TAK-583|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease (COPD)|Smoking|Smoking Cessation|Idiopathic Pulmonary Fibrosis (IPF)|Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD)|Scleroderma-Associated Interstitial Lung Disease (SSC-ILD)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparing 150cm OAGB With 150cm Biliopancreatic Limb RYGB. A Non-inferiority Trial
Status: RECRUITING
Conditions: Bariatric Surgery Candidate|Obesity|Obesity, Morbid
Interventions: PROCEDURE: OAGB|PROCEDURE: RYGB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Of Different Simulation Methods As A Training Strategy In Basic Life Support
Status: UNKNOWN
Conditions: Nurse's Role|Simulation Training|Cardiopulmonary Resuscitation
Interventions: OTHER: Virtual Reality Training|OTHER: High Fidelity Simulation Training|OTHER: Low Fidelity Simulation Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1
Status: RECRUITING
Conditions: Type 1 Diabetes
Interventions: DRUG: Resveratrol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Proof of Principle Study Evaluating Gonyautoxins NEURO SERUM, on Chemotherapy-induced Peripheral Neuropathy
Status: RECRUITING
Conditions: Chemotherapy-induced Peripheral Neuropathy
Interventions: DRUG: PSP NEURO SERUM|DRUG: Placebo PSP NEURO SERUM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bortezomib and Combination Chemotherapy in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: bortezomib|DRUG: carboplatin|DRUG: etoposide|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Clinical Response of Subretinal Administration of CNTO 2476 in Participants With Geographic Atrophy
Status: COMPLETED
Conditions: Visual Acuity|Geographic Atrophy|Macular Degeneration
Interventions: DRUG: CNTO 2476 3.0 x 10^5 cells|DEVICE: Subretinal Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fruit and Vegetable Extracts in Treating Patients With Stage I-IV, Stage IVA/IVB Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DIETARY_SUPPLEMENT: fruit and vegetable extracts|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Inotuzumab Ozogamicin in Treating Adult Patients With Ph Negative ALL With Minimal Residual Disease Positive After Induction Chemotherapy
Status: NOT_YET_RECRUITING
Conditions: Acute Lymphocytic Leukemia
Interventions: DRUG: Inotuzumab ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Resilience to Food Commercials Decreases Susceptibility to Unhealthy Food Decision-Making
Status: COMPLETED
Conditions: Obesity, Adolescent
Interventions: BEHAVIORAL: Commercial Advertising Literacy Training|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Remote Ischemic Conditioning on Myocardial Perfusion in Humans
Status: COMPLETED
Conditions: Ischemic Heart Disease
Interventions: OTHER: Remote Ischemic Conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of GABA Modulator AZD7325 on Cortical Excitability
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 2 mg AZD7325|DRUG: 10 mg AZD7325|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Niraparib Combined With Oral Etoposide in Platinum Resistant/Refractory Recurrent Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Detection of Pancreatic Cystic Neoplasms
Status: RECRUITING
Conditions: Pancreatic Cysts|Intraductal Papillary Mucinous Neoplasm|Pancreatic Mucinous-Cystic Neoplasm|Cystic, Mucinous and/or Serous Neoplasm|Solid Pseudopapillary Tumour of the Pancreas
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Oltipraz in the Patients With Liver Fibrosis and Cirrhosis
Status: COMPLETED
Conditions: Liver Fibrosis|Liver Cirrhosis
Interventions: DRUG: oltipraz|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Sequestration of Platelets Prior to Bypass Reduces Bleeding After Cardiac Surgery
Status: TERMINATED
Conditions: Cardiac Surgical Procedures|Cardiopulmonary Bypass|Blood Platelet Disorders|Blood Coagulation Disorders
Interventions: PROCEDURE: Platelet rich plasma sequestration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Whole-Body Electromyostimulation Application in Individuals With Lumbar Disc Hernia
Status: COMPLETED
Conditions: Lumbar Disc Herniation
Interventions: OTHER: Whole-Body Electromyostimulation Group|OTHER: Exercise Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Surgical Glove Contamination During Total Knee Arthroplasty Procedure : a Randomized Controlled Trial
Status: UNKNOWN
Conditions: Surgical Glove|Total Knee Arthroplasty|Contamination Rate
Interventions: PROCEDURE: Surgical glove changing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Protein Quality During Overreaching in Trained Cyclists
Status: COMPLETED
Conditions: Muscle Protein Synthesis
Interventions: DIETARY_SUPPLEMENT: Alpha-lactalbumin|DIETARY_SUPPLEMENT: Collagen peptides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Risk-adapted Therapy for Primary Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: Idarubicin|DRUG: Ara-C|DRUG: G-CSF|PROCEDURE: Allogeneic matched or unrelated donor transplant.|PROCEDURE: Autologous peripheral blood stem cell transplant|PROCEDURE: Measurable residual disease
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Plus Radiation Therapy With or Without Amifostine in Treating Patients With Locally Advanced Cancer of the Nasopharynx
Status: TERMINATED
Conditions: Drug/Agent Toxicity by Tissue/Organ|Head and Neck Cancer|Oral Complications|Radiation Toxicity
Interventions: DRUG: amifostine trihydrate|DRUG: carboplatin|DRUG: cisplatin|DRUG: paclitaxel|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The IPED (Investigation of Palpitations in the ED) Study
Status: COMPLETED
Conditions: Presyncope|Arrhythmias, Cardiac|Tachycardia, Supraventricular|Atrial Fibrillation
Interventions: DEVICE: AliveCor Heart Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vaccine Therapy Plus Sargramostim Following Chemotherapy in Treating Stage III or Stage IV Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: keyhole limpet hemocyanin|BIOLOGICAL: sargramostim|BIOLOGICAL: tumor cell-based vaccine therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Azelastine Fluticasone Combination vs. Fluticasone
Status: WITHDRAWN
Conditions: Allergic Rhinitis
Interventions: DRUG: Azelastine , fluticasone|DRUG: Fluticasone propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retrieval Versus Mid-luteal Endometrial Scratching (ES) for Intra Cytoplasmic Sperm Injection (ICSI)
Status: UNKNOWN
Conditions: ICSI
Interventions: PROCEDURE: Endometrial scratching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Free Neurovascularized Muscle Transfer in Facial Reanimation of Long-standing Facial Palsy Patients
Status: NOT_YET_RECRUITING
Conditions: Facial Paralysis
Interventions: PROCEDURE: Facial reanimation surgery by free muscle trasfer.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dietary Supplementation on Intestinal Barrier Function in IBS-D
Status: NOT_YET_RECRUITING
Conditions: Irritable Bowel Syndrome With Diarrhea
Interventions: DIAGNOSTIC_TEST: Lactulose/Mannitol Ratio Test|DIAGNOSTIC_TEST: Serum biomarkers of intestinal permeability|OTHER: Rome IV questionnaire|OTHER: Irritable bowel severity scoring system|OTHER: Bowel Habit diary|OTHER: 3 day dietary record|DIETARY_SUPPLEMENT: NCT and NFT|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Office Hysteroscopy and 3D Power Doppler Vaginal Ultrasound in Assessment of Postmenopausal Bleeding
Status: COMPLETED
Conditions: Postmenopausal Bleeding
Interventions: PROCEDURE: 2D grey scale vaginal ultrasound|PROCEDURE: 3D power Doppler vaginal ultrasound|PROCEDURE: Office hysteroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Micro-injections of Transparent Hyaluronic Acid Gel (Restylane® Silk) for Rejuvenation of the Aging Cheek
Status: UNKNOWN
Conditions: Wrinkle
Interventions: DEVICE: Restylane® Silk
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PT-STRESS Study: Predicting Treatment Success and Dealing With Non-response in the Treatment of PTSD
Status: RECRUITING
Conditions: Stress Disorders, Post-Traumatic
Interventions: BEHAVIORAL: Prolonged Exposure therapy|BEHAVIORAL: Eye Movement Desensitization Reprocessing (EMDR)|BEHAVIORAL: Interpersonal Psychotherapy (IPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SHR-1210 Combined With Albumin-bound Paclitaxel and Epirubicin Neoadjuvant for Triple Negative Breast Cancer
Status: UNKNOWN
Conditions: Triple-negative Breast Cancer
Interventions: DRUG: SHR-1210+Albumin-bound paclitaxel + epirubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Naltrexone for Antipsychotic-Induced Weight Gain
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder|Bipolar Disorder|Severe Major Depression With Psychotic Features
Interventions: DRUG: Naltrexone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of the Supraspinal Opioidergic Circuit in Prefrontal TMS-Induced Analgesia
Status: COMPLETED
Conditions: Pain
Interventions: PROCEDURE: Sham rTMS|PROCEDURE: Real rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Investigation of the Next Generation Intraocular Lens
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Investigational Intraocular Lens Device #1: Next Generation TECNIS IOL|DEVICE: Control Monofocal Intraocular Lens: TECNIS Monofocal IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Programmed Death-1 (PD-1) Antibody Combined With Chemoradiotherapy in High-risk Recurrent Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Recurrent Nasopharyngeal Carcinoma
Interventions: DRUG: PD-1 blocking antibody|DRUG: Chemotherapy|RADIATION: IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating Stereotactic Radiotherapy Plus Durvalumab Continuation for Patients With NSCLC Metachronous Oligometastatic Disease Under Durvalumab Consolidation Following Chemoradiation
Status: ACTIVE_NOT_RECRUITING
Conditions: NSCLC
Interventions: COMBINATION_PRODUCT: Radiotherapy + durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the KinexConnect Telerehabilitation System (KCTRS)
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: BEHAVIORAL: Telerehabilitation using the KinexConnect system for rehabilitation after TKA.|BEHAVIORAL: Traditional outpatient PT for rehabilitation after TKA.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Timolol for Superficial Infantile Hemangioma
Status: COMPLETED
Conditions: Hemangioma
Interventions: DRUG: 0.5% timolol maleate eye drop|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MRI Neurofeedback and Brain Circuits Related to Motivation in Healthy Participants
Status: RECRUITING
Conditions: Motivation|Memory|Self-regulation
Interventions: BEHAVIORAL: Ventral tegmental area of dopaminergic midbrain (VTA) fMRI neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of Pulmozyme in Infants With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Recombinant Human DNase (Pulmozyme)|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis
Status: COMPLETED
Conditions: Irreversible Pulpitis
Interventions: DRUG: 4%articaine|DRUG: 2% Lignocaine|DRUG: Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK)
Status: COMPLETED
Conditions: Venous Thrombosis|Pulmonary Embolism|Atrial Fibrillation|Acute Coronary Syndrome
Interventions: DRUG: Rivaroxaban (Xarelto, Bay59-7939)|DRUG: Warfarin|DRUG: Antiplatelet drugs
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment by HIFU With Focal One® of Posterior Deep Infiltrating Endometriosis Lesions With Intestinal Involvement.
Status: COMPLETED
Conditions: Endometriosis
Interventions: DEVICE: HIFU (Focal One®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efgartigimod in Acute Neuromyelitis Optica Spectrum Disorders
Status: NOT_YET_RECRUITING
Conditions: Neuromyelitis Optica|Efgartigimod
Interventions: DRUG: Intravenous methylprednisolone (IVMP) and Efgartigimod|DRUG: IVMP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis
Status: COMPLETED
Conditions: Endogenous Anterior Uveitis
Interventions: DRUG: Difluprednate 0.05% ophthalmic emulsion|DRUG: Prednisolone acetate 1.0% ophthalmic suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Exercise and Alternative Applications of NMES on Pain and Function in Patients With Knee OA
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Neuromuscular Electrical Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of a Single Subretinal Injection of JWK002 Gene Therapy in Subjects With X-linked Retinoschisis(XLRS)
Status: RECRUITING
Conditions: X Linked Retinoschisis
Interventions: DRUG: JWK002
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Environmental Emissions From Electronic Cigarettes and Tobacco-Burning Cigarettes
Status: COMPLETED
Conditions: Smoking
Interventions: OTHER: Leading U.S. non-menthol cigarette|OTHER: Leading U.S. menthol cigarette|OTHER: Electronic cigarette #1|OTHER: Electronic cigarette #2|OTHER: Electronic cigarette #3|OTHER: U.S. Market-sample electronic cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of the Efficacy, Safety, and Pharmacokinetics of SM88 in Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Rising Prostate Specific Antigen (PSA)
Interventions: DRUG: SM88 (Cohort 1)|DRUG: SM88 (Cohort 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of an Investigational mRNA-1273.815 COVID-19 Vaccine in Previously Vaccinated Adults
Status: COMPLETED
Conditions: SARS-CoV-2
Interventions: BIOLOGICAL: Investigational mRNA-1273.815|BIOLOGICAL: Licensed Spikevax Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Laser Assisted Hair Removal in the Treatment of Acne Keloidalis Nuchae; a Pilot Study
Status: COMPLETED
Conditions: Acne Keloidalis Nuchae
Interventions: DEVICE: Nd-YAG laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of RBD1016 in CHB Participants
Status: RECRUITING
Conditions: Chronic Hepatitis b
Interventions: DRUG: RBD1016|DRUG: RBD1016+PegIFN-α
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efavirenz Comparative Bioavailability
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Efavirenz 600 Test-Stocrin 600 Reference|DRUG: Stocrin 600 Reference-Efavirenz 600 Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Perfusion Assessment With Contrast-Enhanced EUS in Locally Advanced and Metastatic Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreas Cancer
Interventions: DIAGNOSTIC_TEST: Endoscopic ultrasound (including fine needle aspiration)|OTHER: Contrast-enhanced endoscopic ultrasound (CE-EUS)|OTHER: Endoscopic ultrasound elastography (EG-EUS)|DIAGNOSTIC_TEST: Contrast-enhanced computed tomography (CT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Guided Imagery for Radiotherapy-Related Distress in Patients With Head and Neck Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer
Interventions: BEHAVIORAL: Guided Imagery|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Epcoritamab (Epcor)-Containing Combination Salvage Therapy Followed by ASCT & Epcor Consolidation in Patients With Relapsed LBCL
Status: RECRUITING
Conditions: DLBCL - Diffuse Large B Cell Lymphoma|High-grade B-cell Lymphoma|High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements|DLBCL, Nos Genetic Subtypes|High Grade B-Cell Lymphoma, Not Otherwise Specified|Follicular Large Cell Lymphoma, Relapsed|Follicular Large Cell Lymphoma
Interventions: DRUG: Epcoritamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dynamic Variation of Impedance Cardiography(DYVIC) as a Diagnostic Tool of Acute Heart Failure (AHF)
Status: COMPLETED
Conditions: Heart Failure
Interventions: DIAGNOSTIC_TEST: Reference position patient is put in a 30 degree supine position during 5 minutes|DIAGNOSTIC_TEST: nitroglucerin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Childhood Acute Erythroleukemia (M6)|Childhood Acute Megakaryocytic Leukemia (M7)|Childhood Acute Monoblastic Leukemia (M5a)|Childhood Acute Monocytic Leukemia (M5b)|Childhood Acute Myeloblastic Leukemia With Maturation (M2)|Childhood Acute Myeloblastic Leukemia Without Maturation (M1)|Childhood Acute Myelomonocytic Leukemia (M4)|Childhood Myelodysplastic Syndromes|Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndromes|Refractory Anemia|Refractory Anemia With Excess Blasts|Refractory Anemia With Excess Blasts in Transformation|Refractory Anemia With Ringed Sideroblasts|Secondary Myelodysplastic Syndromes|Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
Interventions: DRUG: asparaginase|DRUG: daunorubicin hydrochloride|DRUG: fludarabine phosphate|DRUG: therapeutic hydrocortisone|PROCEDURE: allogeneic bone marrow transplantation|RADIATION: 3-dimensional conformal radiation therapy|BIOLOGICAL: filgrastim|DRUG: cytarabine|DRUG: idarubicin|DRUG: dexamethasone|DRUG: thioguanine|DRUG: etoposide|DRUG: methotrexate|DRUG: cyclophosphamide|BIOLOGICAL: aldesleukin|DRUG: busulfan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Operative Gynecological Oncology App Study
Status: COMPLETED
Conditions: Genital Neoplasm, Female
Interventions: BEHAVIORAL: Discharge instructions reminders|BEHAVIORAL: Prompts to report symptoms via the web-enabled app|BEHAVIORAL: Clinical Alerts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Precision Chemotherapy Based on Organoid Drug Sensitivity for Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: FOLFOX , FOLFIRI or FOLFOXIRI regimens|DRUG: FOLFOX or CapeOX regimens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intramedullary Screw Versus Plate in Displaced Midshaft Clavicle Fractures
Status: UNKNOWN
Conditions: Clavicle Fracture
Interventions: PROCEDURE: Plate fixation|PROCEDURE: Intramedullary Screw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bread Daily Intake Enriched With Mix Fibers in Metabolic Subjects: Intestinal Microbiota and Metabolic Profile Impact
Status: COMPLETED
Conditions: Healthy Obesity, Metabolically
Interventions: OTHER: 150 g bread fortified (15 g mix fibre)|OTHER: 150 g unfortified bread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tittle: Effect of Video-Based Health Education Intervention on Insulin Therapy Among Adults With Diabetes Mellitus in Dhulikhel Hospital
Status: NOT_YET_RECRUITING
Conditions: Knowledge on Insulin Therapy|Practice on Insulin Administration
Interventions: OTHER: video-based health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Auto-Allo Tandem Stem Cell Transplantation for Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: PROCEDURE: Auto-Allo Tandem SCT and maintenance therapy with Thalidomide/ DLI|PROCEDURE: auto-auto Tandem stem cell transplantation and maintenance therapy with Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Incidence of Complete Posterior Vitreous Degeneration After Phacoemulsification
Status: RECRUITING
Conditions: Posterior Vitreous Detachment
Interventions: DEVICE: Wide-field optical coherence tomography (Optovue®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Insulin Glulisine in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin Glargine|DRUG: Glimepiride|DRUG: Insulin Glulisine|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DexmedetOmidine Complement Treats Chronic insOmnia and Improves Circadian Rhythm (DOCTOR)
Status: COMPLETED
Conditions: Chronic Insomnia
Interventions: DRUG: dexmedetomidine|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized Targeted Preparative Regimen Before T-depleted Allogeneic HSCT in Children With Chemoresistent Acute Leukemias
Status: UNKNOWN
Conditions: Refractory Acute Myeloid Leukemia|Refractory Acute Lymphoblastic Leukemia
Interventions: DRUG: Preparative regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NeoSync TMS Treatment for Bipolar I Depression
Status: TERMINATED
Conditions: Major Depressive Episode|Bipolar Depression|Bipolar Disorder|Mood Disorders
Interventions: DEVICE: NEST (NeoSync EEG Synchronized TMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Fatigue in Colorectal Cancer Survivors, a Lifestyle Intervention
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer|Cancer-related Fatigue|Colon Cancer|Rectal Cancer
Interventions: BEHAVIORAL: Behaviour change guided lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Crystalloid Fluid Choice and Neurological Outcome in Patients After Subarachnoid Haemorrhage
Status: RECRUITING
Conditions: Subarachnoid Hemorrhage|Critical Illness|Infusion Fluid|Sodium Disorder
Interventions: DRUG: 0.9% Sodium-chloride|DRUG: Ringer's Lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: TIPS vs. NSBB Plus Endotherapy for the Prevention of Variceal Rebleeding in NSBB Non-responders of Primary Prophylaxis
Status: UNKNOWN
Conditions: Variceal Hemorrhage|TIPS|NSBB|Liver Cirrhosis
Interventions: PROCEDURE: Transjugular intrahepatic portosystemic shunts|OTHER: Nonselective β-blocker (NSBB)+ endoscopic band ligation (EBL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Convalescent Plasma Transfusion in Severe COVID-19 Patients in Jamaica
Status: UNKNOWN
Conditions: COVID-19, Convalescent Plasma Treatment
Interventions: BIOLOGICAL: Convalescent Plasma Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation and Dose Expansion Study of Tirabrutinib in Combination With Other Targeted Anti-cancer Therapies in Adults With B-cell Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: B-cell Malignancies
Interventions: DRUG: Tirabrutinib|DRUG: Idelalisib|DRUG: Entospletinib|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of the Malaria Vaccines FP9 PP and MVA PP
Status: COMPLETED
Conditions: Malaria, Falciparum|Malaria
Interventions: BIOLOGICAL: FP9-PP (FP9 polyprotein)|BIOLOGICAL: MVA-PP (Modified Virus Ankara polyprotein)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System for Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DEVICE: SyntrFuge System|DRUG: Triamcinolone Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A FDG-PET Study of AGN-242071 Added to Standard-of-Care (Donepezil ± Memantine) for the Treatment of Participants With Mild to Moderate Alzheimer's Disease
Status: WITHDRAWN
Conditions: Alzheimer's Disease
Interventions: DRUG: AGN-242071|DRUG: Placebo|DRUG: Donepezil|DRUG: Memantine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lidocaine vs Ketorolac for Management of Renal Colic in the Emergency Department
Status: UNKNOWN
Conditions: Renal Colic
Interventions: DRUG: Lidocaine|DRUG: Ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Azelastine +Mometasone , Nasal Spray, 140 mcg + 50 mcg, (Sandoz d.d., Slovenia) and Momat Rino Advance, Nasal Spray, 140 mcg + 50 mcg, (Glenmark, India) Administered as a Monotherapy to Patients With Seasonal Allergic Rhinitis.
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: COMBINATION_PRODUCT: Azelastine + Mometazone, nasal spray|COMBINATION_PRODUCT: Momat Rhino Advance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neck Exercises in Patients With Temporomandibular Disorders
Status: ACTIVE_NOT_RECRUITING
Conditions: Temporomandibular Disorders|Temporomandibular Joint Pain
Interventions: OTHER: Exercises|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Triple Therapy Convenience by the Use of One or Multiple Inhalers and Digital Support in Chronic Obstructive Pulmonary Disease
Status: RECRUITING
Conditions: Copd|Adherence, Medication
Interventions: DRUG: single-inhaler triple therapy (Trimbow)|DEVICE: E-health application: Curavista app & FindAir e-device|DRUG: multi-inhaler triple therapy (Qvar + Bevespi)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Malaria Elimination Pilot Study in Military Forces in Cambodia
Status: UNKNOWN
Conditions: Malaria|Parasitic Diseases
Interventions: DRUG: DHA-PIP|DRUG: Primaquine|DRUG: Artesunate + Mefloquine|DRUG: Permethrin (Insecticide treated uniform)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Safety and Efficacy of INC280 and Cetuximab, in Adult c-MET Positive mCRC and HNSCC Patients After Progression on Cetuximab or Panitumumab Therapy
Status: TERMINATED
Conditions: Squamous Cell Carcinoma of Head and Neck (SCCHN)|Metastatic Colorectal Cancer
Interventions: DRUG: INC280|DRUG: cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-time Ultrasound Guidance for Thoracic Epidural Blocks
Status: NOT_YET_RECRUITING
Conditions: Analgesia|Thoracic Tumors|Abdomen Tumors|Rib Fractures
Interventions: PROCEDURE: Real-time ultrasound guidance for thoracic epidural catheter placement.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Early Switch From Controlled to Assisted Ventilation
Status: RECRUITING
Conditions: Acute Hypoxemic Respiratory Failure|Mechanical Ventilation
Interventions: OTHER: Pre-specified switch from controlled to assisted ventilation when PaO2/FiO2-ratio > 200 mmHg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Laparoscopic Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) for Metastatic Gastric Cancer
Status: COMPLETED
Conditions: Gastrointestinal Cancer
Interventions: DRUG: Mitomycin C|DRUG: Cisplatin|DRUG: Sodium Thiosulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomechanical Taping on Low Back Pain With Increased Foot Pronation
Status: UNKNOWN
Conditions: Low Back Pain|Foot Posture|Taping|Functional Mitral Regurgitation
Interventions: OTHER: Taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Effect of Neoadjuvant Hierarchical Treatment Based on Chemotherapy
Status: UNKNOWN
Conditions: Rectum Cancer
Interventions: PROCEDURE: TME|RADIATION: Concurrent chemo-radiotherapy|DRUG: neoadjuvant CT|DRUG: adjuvant CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Stem Cells in Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: Bone Marrow Autologous Stem Cells Infusion|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Unilateral and Bilateral Exercise Training in Patients With Lateral Ankle Instability
Status: COMPLETED
Conditions: Chronic Ankle Instability
Interventions: OTHER: Unilateral Exercise Group|OTHER: Bilateral Exercise Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Ocoxin-Viusid® in Advanced Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Adenocarcinoma of the Pancreas|Pancreatic Cancer|Advanced Cancer|Digestive System Neoplasms|Pancreatic Neoplasms|Endocrine Gland Neoplasms|Digestive System Diseases|Endocrine System Diseases|Pancreatic Diseases
Interventions: DIETARY_SUPPLEMENT: Ocoxin-Viusid®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: POEMS Syndrome Treatment With Lenalidomide
Status: COMPLETED
Conditions: POEMS Syndrome
Interventions: DRUG: Lenalidomide and dexamethasone|DRUG: Lenalidomide and dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Progressive Esophageal Dilation for Benign Strictures: a Randomized Controlled Trial
Status: UNKNOWN
Conditions: Benign Esophageal Stricture
Interventions: DEVICE: Savary bougie dilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Three-dimensional Changes in Free Gingival Grafts Around Dental Implants
Status: NOT_YET_RECRUITING
Conditions: Insufficient Keratinized Gingiva
Interventions: PROCEDURE: Free gingival graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION